data_9MC8
# 
_entry.id   9MC8 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9MC8         pdb_00009mc8 10.2210/pdb9mc8/pdb 
WWPDB D_1300057552 ?            ?                   
EMDB  EMD-63792    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-06-18 ? 
2 'EM metadata'     1 0 2025-06-18 ? 
3 FSC               1 0 2025-06-18 ? 
4 'Half map'        1 0 2025-06-18 1 
5 'Half map'        1 0 2025-06-18 2 
6 Image             1 0 2025-06-18 ? 
7 'Primary map'     1 0 2025-06-18 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 FSC               repository 'Initial release' ? ? 
4 4 'Half map'        repository 'Initial release' ? ? 
5 5 'Half map'        repository 'Initial release' ? ? 
6 6 Image             repository 'Initial release' ? ? 
7 7 'Primary map'     repository 'Initial release' ? ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9MC8 
_pdbx_database_status.recvd_initial_deposition_date   2025-03-17 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM structure of human OAT1 in complex with PAH' 
_pdbx_database_related.db_id          EMD-63792 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              zyq_lab@fudan.edu.cn 
_pdbx_contact_author.name_first         Yanqing 
_pdbx_contact_author.name_last          Zhang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-7654-1645 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zhang, W.' 1 ? 
'Zhang, Y.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Cryo-EM structure of human OAT1 in complex with PAH' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zhang, W.' 1 ? 
primary 'Zhang, Y.' 2 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Isoform 2 of Solute carrier family 22 member 6' 63119.156 1 ? ? ? ? 
2 non-polymer syn 'N-(4-aminobenzoyl)glycine'                      194.187   1 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Organic anion transporter 1,hOAT1,PAH transporter,hPAHT,Renal organic anion transporter 1,hROAT1' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEVWLPRDRQGQPESCLR
FTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLG
RRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV
AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMG
KGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMA
ALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAE
LYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRKGKQTRQQQEHQKYMVPLQASAQEKNGLHHHHHHHHHH
GSVEDYKDDDDK
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEVWLPRDRQGQPESCLR
FTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLG
RRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV
AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMG
KGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMA
ALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAE
LYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRKGKQTRQQQEHQKYMVPLQASAQEKNGLHHHHHHHHHH
GSVEDYKDDDDK
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        'N-(4-aminobenzoyl)glycine' 
_pdbx_entity_nonpoly.comp_id     ZWD 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   PHE n 
1 4   ASN n 
1 5   ASP n 
1 6   LEU n 
1 7   LEU n 
1 8   GLN n 
1 9   GLN n 
1 10  VAL n 
1 11  GLY n 
1 12  GLY n 
1 13  VAL n 
1 14  GLY n 
1 15  ARG n 
1 16  PHE n 
1 17  GLN n 
1 18  GLN n 
1 19  ILE n 
1 20  GLN n 
1 21  VAL n 
1 22  THR n 
1 23  LEU n 
1 24  VAL n 
1 25  VAL n 
1 26  LEU n 
1 27  PRO n 
1 28  LEU n 
1 29  LEU n 
1 30  LEU n 
1 31  MET n 
1 32  ALA n 
1 33  SER n 
1 34  HIS n 
1 35  ASN n 
1 36  THR n 
1 37  LEU n 
1 38  GLN n 
1 39  ASN n 
1 40  PHE n 
1 41  THR n 
1 42  ALA n 
1 43  ALA n 
1 44  ILE n 
1 45  PRO n 
1 46  THR n 
1 47  HIS n 
1 48  HIS n 
1 49  CYS n 
1 50  ARG n 
1 51  PRO n 
1 52  PRO n 
1 53  ALA n 
1 54  ASP n 
1 55  ALA n 
1 56  ASN n 
1 57  LEU n 
1 58  SER n 
1 59  LYS n 
1 60  ASN n 
1 61  GLY n 
1 62  GLY n 
1 63  LEU n 
1 64  GLU n 
1 65  VAL n 
1 66  TRP n 
1 67  LEU n 
1 68  PRO n 
1 69  ARG n 
1 70  ASP n 
1 71  ARG n 
1 72  GLN n 
1 73  GLY n 
1 74  GLN n 
1 75  PRO n 
1 76  GLU n 
1 77  SER n 
1 78  CYS n 
1 79  LEU n 
1 80  ARG n 
1 81  PHE n 
1 82  THR n 
1 83  SER n 
1 84  PRO n 
1 85  GLN n 
1 86  TRP n 
1 87  GLY n 
1 88  LEU n 
1 89  PRO n 
1 90  PHE n 
1 91  LEU n 
1 92  ASN n 
1 93  GLY n 
1 94  THR n 
1 95  GLU n 
1 96  ALA n 
1 97  ASN n 
1 98  GLY n 
1 99  THR n 
1 100 GLY n 
1 101 ALA n 
1 102 THR n 
1 103 GLU n 
1 104 PRO n 
1 105 CYS n 
1 106 THR n 
1 107 ASP n 
1 108 GLY n 
1 109 TRP n 
1 110 ILE n 
1 111 TYR n 
1 112 ASP n 
1 113 ASN n 
1 114 SER n 
1 115 THR n 
1 116 PHE n 
1 117 PRO n 
1 118 SER n 
1 119 THR n 
1 120 ILE n 
1 121 VAL n 
1 122 THR n 
1 123 GLU n 
1 124 TRP n 
1 125 ASP n 
1 126 LEU n 
1 127 VAL n 
1 128 CYS n 
1 129 SER n 
1 130 HIS n 
1 131 ARG n 
1 132 ALA n 
1 133 LEU n 
1 134 ARG n 
1 135 GLN n 
1 136 LEU n 
1 137 ALA n 
1 138 GLN n 
1 139 SER n 
1 140 LEU n 
1 141 TYR n 
1 142 MET n 
1 143 VAL n 
1 144 GLY n 
1 145 VAL n 
1 146 LEU n 
1 147 LEU n 
1 148 GLY n 
1 149 ALA n 
1 150 MET n 
1 151 VAL n 
1 152 PHE n 
1 153 GLY n 
1 154 TYR n 
1 155 LEU n 
1 156 ALA n 
1 157 ASP n 
1 158 ARG n 
1 159 LEU n 
1 160 GLY n 
1 161 ARG n 
1 162 ARG n 
1 163 LYS n 
1 164 VAL n 
1 165 LEU n 
1 166 ILE n 
1 167 LEU n 
1 168 ASN n 
1 169 TYR n 
1 170 LEU n 
1 171 GLN n 
1 172 THR n 
1 173 ALA n 
1 174 VAL n 
1 175 SER n 
1 176 GLY n 
1 177 THR n 
1 178 CYS n 
1 179 ALA n 
1 180 ALA n 
1 181 PHE n 
1 182 ALA n 
1 183 PRO n 
1 184 ASN n 
1 185 PHE n 
1 186 PRO n 
1 187 ILE n 
1 188 TYR n 
1 189 CYS n 
1 190 ALA n 
1 191 PHE n 
1 192 ARG n 
1 193 LEU n 
1 194 LEU n 
1 195 SER n 
1 196 GLY n 
1 197 MET n 
1 198 ALA n 
1 199 LEU n 
1 200 ALA n 
1 201 GLY n 
1 202 ILE n 
1 203 SER n 
1 204 LEU n 
1 205 ASN n 
1 206 CYS n 
1 207 MET n 
1 208 THR n 
1 209 LEU n 
1 210 ASN n 
1 211 VAL n 
1 212 GLU n 
1 213 TRP n 
1 214 MET n 
1 215 PRO n 
1 216 ILE n 
1 217 HIS n 
1 218 THR n 
1 219 ARG n 
1 220 ALA n 
1 221 CYS n 
1 222 VAL n 
1 223 GLY n 
1 224 THR n 
1 225 LEU n 
1 226 ILE n 
1 227 GLY n 
1 228 TYR n 
1 229 VAL n 
1 230 TYR n 
1 231 SER n 
1 232 LEU n 
1 233 GLY n 
1 234 GLN n 
1 235 PHE n 
1 236 LEU n 
1 237 LEU n 
1 238 ALA n 
1 239 GLY n 
1 240 VAL n 
1 241 ALA n 
1 242 TYR n 
1 243 ALA n 
1 244 VAL n 
1 245 PRO n 
1 246 HIS n 
1 247 TRP n 
1 248 ARG n 
1 249 HIS n 
1 250 LEU n 
1 251 GLN n 
1 252 LEU n 
1 253 LEU n 
1 254 VAL n 
1 255 SER n 
1 256 ALA n 
1 257 PRO n 
1 258 PHE n 
1 259 PHE n 
1 260 ALA n 
1 261 PHE n 
1 262 PHE n 
1 263 ILE n 
1 264 TYR n 
1 265 SER n 
1 266 TRP n 
1 267 PHE n 
1 268 PHE n 
1 269 ILE n 
1 270 GLU n 
1 271 SER n 
1 272 ALA n 
1 273 ARG n 
1 274 TRP n 
1 275 HIS n 
1 276 SER n 
1 277 SER n 
1 278 SER n 
1 279 GLY n 
1 280 ARG n 
1 281 LEU n 
1 282 ASP n 
1 283 LEU n 
1 284 THR n 
1 285 LEU n 
1 286 ARG n 
1 287 ALA n 
1 288 LEU n 
1 289 GLN n 
1 290 ARG n 
1 291 VAL n 
1 292 ALA n 
1 293 ARG n 
1 294 ILE n 
1 295 ASN n 
1 296 GLY n 
1 297 LYS n 
1 298 ARG n 
1 299 GLU n 
1 300 GLU n 
1 301 GLY n 
1 302 ALA n 
1 303 LYS n 
1 304 LEU n 
1 305 SER n 
1 306 MET n 
1 307 GLU n 
1 308 VAL n 
1 309 LEU n 
1 310 ARG n 
1 311 ALA n 
1 312 SER n 
1 313 LEU n 
1 314 GLN n 
1 315 LYS n 
1 316 GLU n 
1 317 LEU n 
1 318 THR n 
1 319 MET n 
1 320 GLY n 
1 321 LYS n 
1 322 GLY n 
1 323 GLN n 
1 324 ALA n 
1 325 SER n 
1 326 ALA n 
1 327 MET n 
1 328 GLU n 
1 329 LEU n 
1 330 LEU n 
1 331 ARG n 
1 332 CYS n 
1 333 PRO n 
1 334 THR n 
1 335 LEU n 
1 336 ARG n 
1 337 HIS n 
1 338 LEU n 
1 339 PHE n 
1 340 LEU n 
1 341 CYS n 
1 342 LEU n 
1 343 SER n 
1 344 MET n 
1 345 LEU n 
1 346 TRP n 
1 347 PHE n 
1 348 ALA n 
1 349 THR n 
1 350 SER n 
1 351 PHE n 
1 352 ALA n 
1 353 TYR n 
1 354 TYR n 
1 355 GLY n 
1 356 LEU n 
1 357 VAL n 
1 358 MET n 
1 359 ASP n 
1 360 LEU n 
1 361 GLN n 
1 362 GLY n 
1 363 PHE n 
1 364 GLY n 
1 365 VAL n 
1 366 SER n 
1 367 ILE n 
1 368 TYR n 
1 369 LEU n 
1 370 ILE n 
1 371 GLN n 
1 372 VAL n 
1 373 ILE n 
1 374 PHE n 
1 375 GLY n 
1 376 ALA n 
1 377 VAL n 
1 378 ASP n 
1 379 LEU n 
1 380 PRO n 
1 381 ALA n 
1 382 LYS n 
1 383 LEU n 
1 384 VAL n 
1 385 GLY n 
1 386 PHE n 
1 387 LEU n 
1 388 VAL n 
1 389 ILE n 
1 390 ASN n 
1 391 SER n 
1 392 LEU n 
1 393 GLY n 
1 394 ARG n 
1 395 ARG n 
1 396 PRO n 
1 397 ALA n 
1 398 GLN n 
1 399 MET n 
1 400 ALA n 
1 401 ALA n 
1 402 LEU n 
1 403 LEU n 
1 404 LEU n 
1 405 ALA n 
1 406 GLY n 
1 407 ILE n 
1 408 CYS n 
1 409 ILE n 
1 410 LEU n 
1 411 LEU n 
1 412 ASN n 
1 413 GLY n 
1 414 VAL n 
1 415 ILE n 
1 416 PRO n 
1 417 GLN n 
1 418 ASP n 
1 419 GLN n 
1 420 SER n 
1 421 ILE n 
1 422 VAL n 
1 423 ARG n 
1 424 THR n 
1 425 SER n 
1 426 LEU n 
1 427 ALA n 
1 428 VAL n 
1 429 LEU n 
1 430 GLY n 
1 431 LYS n 
1 432 GLY n 
1 433 CYS n 
1 434 LEU n 
1 435 ALA n 
1 436 ALA n 
1 437 SER n 
1 438 PHE n 
1 439 ASN n 
1 440 CYS n 
1 441 ILE n 
1 442 PHE n 
1 443 LEU n 
1 444 TYR n 
1 445 THR n 
1 446 GLY n 
1 447 GLU n 
1 448 LEU n 
1 449 TYR n 
1 450 PRO n 
1 451 THR n 
1 452 MET n 
1 453 ILE n 
1 454 ARG n 
1 455 GLN n 
1 456 THR n 
1 457 GLY n 
1 458 MET n 
1 459 GLY n 
1 460 MET n 
1 461 GLY n 
1 462 SER n 
1 463 THR n 
1 464 MET n 
1 465 ALA n 
1 466 ARG n 
1 467 VAL n 
1 468 GLY n 
1 469 SER n 
1 470 ILE n 
1 471 VAL n 
1 472 SER n 
1 473 PRO n 
1 474 LEU n 
1 475 VAL n 
1 476 SER n 
1 477 MET n 
1 478 THR n 
1 479 ALA n 
1 480 GLU n 
1 481 LEU n 
1 482 TYR n 
1 483 PRO n 
1 484 SER n 
1 485 MET n 
1 486 PRO n 
1 487 LEU n 
1 488 PHE n 
1 489 ILE n 
1 490 TYR n 
1 491 GLY n 
1 492 ALA n 
1 493 VAL n 
1 494 PRO n 
1 495 VAL n 
1 496 ALA n 
1 497 ALA n 
1 498 SER n 
1 499 ALA n 
1 500 VAL n 
1 501 THR n 
1 502 VAL n 
1 503 LEU n 
1 504 LEU n 
1 505 PRO n 
1 506 GLU n 
1 507 THR n 
1 508 LEU n 
1 509 GLY n 
1 510 GLN n 
1 511 PRO n 
1 512 LEU n 
1 513 PRO n 
1 514 ASP n 
1 515 THR n 
1 516 VAL n 
1 517 GLN n 
1 518 ASP n 
1 519 LEU n 
1 520 GLU n 
1 521 SER n 
1 522 ARG n 
1 523 LYS n 
1 524 GLY n 
1 525 LYS n 
1 526 GLN n 
1 527 THR n 
1 528 ARG n 
1 529 GLN n 
1 530 GLN n 
1 531 GLN n 
1 532 GLU n 
1 533 HIS n 
1 534 GLN n 
1 535 LYS n 
1 536 TYR n 
1 537 MET n 
1 538 VAL n 
1 539 PRO n 
1 540 LEU n 
1 541 GLN n 
1 542 ALA n 
1 543 SER n 
1 544 ALA n 
1 545 GLN n 
1 546 GLU n 
1 547 LYS n 
1 548 ASN n 
1 549 GLY n 
1 550 LEU n 
1 551 HIS n 
1 552 HIS n 
1 553 HIS n 
1 554 HIS n 
1 555 HIS n 
1 556 HIS n 
1 557 HIS n 
1 558 HIS n 
1 559 HIS n 
1 560 HIS n 
1 561 GLY n 
1 562 SER n 
1 563 VAL n 
1 564 GLU n 
1 565 ASP n 
1 566 TYR n 
1 567 LYS n 
1 568 ASP n 
1 569 ASP n 
1 570 ASP n 
1 571 ASP n 
1 572 LYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   572 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'SLC22A6, OAT1, PAHT' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                     ?                         'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                    ?                         'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                  ?                         'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'             ?                         'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                    ?                         'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE                   ?                         'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'             ?                         'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                     ?                         'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                   ?                         'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE                  ?                         'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                     ?                         'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                      ?                         'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                  ?                         'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE               ?                         'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                     ?                         'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                      ?                         'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                   ?                         'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                  ?                         'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                    ?                         'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                      ?                         'C5 H11 N O2'    117.146 
ZWD non-polymer         . 'N-(4-aminobenzoyl)glycine' 'Para-aminohippuric acid' 'C9 H10 N2 O3'   194.187 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ALA 2   2   ?   ?   ?   A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ASN 4   4   4   ASN ASN A . n 
A 1 5   ASP 5   5   5   ASP ASP A . n 
A 1 6   LEU 6   6   6   LEU LEU A . n 
A 1 7   LEU 7   7   7   LEU LEU A . n 
A 1 8   GLN 8   8   8   GLN GLN A . n 
A 1 9   GLN 9   9   9   GLN GLN A . n 
A 1 10  VAL 10  10  10  VAL VAL A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  GLY 12  12  12  GLY GLY A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLY 14  14  14  GLY GLY A . n 
A 1 15  ARG 15  15  15  ARG ARG A . n 
A 1 16  PHE 16  16  16  PHE PHE A . n 
A 1 17  GLN 17  17  17  GLN GLN A . n 
A 1 18  GLN 18  18  18  GLN GLN A . n 
A 1 19  ILE 19  19  19  ILE ILE A . n 
A 1 20  GLN 20  20  20  GLN GLN A . n 
A 1 21  VAL 21  21  21  VAL VAL A . n 
A 1 22  THR 22  22  22  THR THR A . n 
A 1 23  LEU 23  23  23  LEU LEU A . n 
A 1 24  VAL 24  24  24  VAL VAL A . n 
A 1 25  VAL 25  25  25  VAL VAL A . n 
A 1 26  LEU 26  26  26  LEU LEU A . n 
A 1 27  PRO 27  27  27  PRO PRO A . n 
A 1 28  LEU 28  28  28  LEU LEU A . n 
A 1 29  LEU 29  29  29  LEU LEU A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  MET 31  31  31  MET MET A . n 
A 1 32  ALA 32  32  32  ALA ALA A . n 
A 1 33  SER 33  33  33  SER SER A . n 
A 1 34  HIS 34  34  34  HIS HIS A . n 
A 1 35  ASN 35  35  35  ASN ASN A . n 
A 1 36  THR 36  36  36  THR THR A . n 
A 1 37  LEU 37  37  37  LEU LEU A . n 
A 1 38  GLN 38  38  38  GLN GLN A . n 
A 1 39  ASN 39  39  39  ASN ASN A . n 
A 1 40  PHE 40  40  40  PHE PHE A . n 
A 1 41  THR 41  41  41  THR THR A . n 
A 1 42  ALA 42  42  42  ALA ALA A . n 
A 1 43  ALA 43  43  43  ALA ALA A . n 
A 1 44  ILE 44  44  44  ILE ILE A . n 
A 1 45  PRO 45  45  45  PRO PRO A . n 
A 1 46  THR 46  46  46  THR THR A . n 
A 1 47  HIS 47  47  47  HIS HIS A . n 
A 1 48  HIS 48  48  48  HIS HIS A . n 
A 1 49  CYS 49  49  49  CYS CYS A . n 
A 1 50  ARG 50  50  50  ARG ARG A . n 
A 1 51  PRO 51  51  51  PRO PRO A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ALA 53  53  53  ALA ALA A . n 
A 1 54  ASP 54  54  ?   ?   ?   A . n 
A 1 55  ALA 55  55  ?   ?   ?   A . n 
A 1 56  ASN 56  56  ?   ?   ?   A . n 
A 1 57  LEU 57  57  ?   ?   ?   A . n 
A 1 58  SER 58  58  ?   ?   ?   A . n 
A 1 59  LYS 59  59  ?   ?   ?   A . n 
A 1 60  ASN 60  60  ?   ?   ?   A . n 
A 1 61  GLY 61  61  ?   ?   ?   A . n 
A 1 62  GLY 62  62  ?   ?   ?   A . n 
A 1 63  LEU 63  63  63  LEU LEU A . n 
A 1 64  GLU 64  64  64  GLU GLU A . n 
A 1 65  VAL 65  65  65  VAL VAL A . n 
A 1 66  TRP 66  66  66  TRP TRP A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  PRO 68  68  68  PRO PRO A . n 
A 1 69  ARG 69  69  69  ARG ARG A . n 
A 1 70  ASP 70  70  70  ASP ASP A . n 
A 1 71  ARG 71  71  71  ARG ARG A . n 
A 1 72  GLN 72  72  72  GLN GLN A . n 
A 1 73  GLY 73  73  73  GLY GLY A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  PRO 75  75  75  PRO PRO A . n 
A 1 76  GLU 76  76  76  GLU GLU A . n 
A 1 77  SER 77  77  77  SER SER A . n 
A 1 78  CYS 78  78  78  CYS CYS A . n 
A 1 79  LEU 79  79  79  LEU LEU A . n 
A 1 80  ARG 80  80  80  ARG ARG A . n 
A 1 81  PHE 81  81  81  PHE PHE A . n 
A 1 82  THR 82  82  82  THR THR A . n 
A 1 83  SER 83  83  83  SER SER A . n 
A 1 84  PRO 84  84  84  PRO PRO A . n 
A 1 85  GLN 85  85  ?   ?   ?   A . n 
A 1 86  TRP 86  86  ?   ?   ?   A . n 
A 1 87  GLY 87  87  ?   ?   ?   A . n 
A 1 88  LEU 88  88  ?   ?   ?   A . n 
A 1 89  PRO 89  89  ?   ?   ?   A . n 
A 1 90  PHE 90  90  ?   ?   ?   A . n 
A 1 91  LEU 91  91  ?   ?   ?   A . n 
A 1 92  ASN 92  92  ?   ?   ?   A . n 
A 1 93  GLY 93  93  ?   ?   ?   A . n 
A 1 94  THR 94  94  ?   ?   ?   A . n 
A 1 95  GLU 95  95  ?   ?   ?   A . n 
A 1 96  ALA 96  96  ?   ?   ?   A . n 
A 1 97  ASN 97  97  ?   ?   ?   A . n 
A 1 98  GLY 98  98  ?   ?   ?   A . n 
A 1 99  THR 99  99  ?   ?   ?   A . n 
A 1 100 GLY 100 100 ?   ?   ?   A . n 
A 1 101 ALA 101 101 ?   ?   ?   A . n 
A 1 102 THR 102 102 102 THR THR A . n 
A 1 103 GLU 103 103 103 GLU GLU A . n 
A 1 104 PRO 104 104 104 PRO PRO A . n 
A 1 105 CYS 105 105 105 CYS CYS A . n 
A 1 106 THR 106 106 106 THR THR A . n 
A 1 107 ASP 107 107 107 ASP ASP A . n 
A 1 108 GLY 108 108 108 GLY GLY A . n 
A 1 109 TRP 109 109 109 TRP TRP A . n 
A 1 110 ILE 110 110 110 ILE ILE A . n 
A 1 111 TYR 111 111 111 TYR TYR A . n 
A 1 112 ASP 112 112 112 ASP ASP A . n 
A 1 113 ASN 113 113 113 ASN ASN A . n 
A 1 114 SER 114 114 114 SER SER A . n 
A 1 115 THR 115 115 115 THR THR A . n 
A 1 116 PHE 116 116 116 PHE PHE A . n 
A 1 117 PRO 117 117 117 PRO PRO A . n 
A 1 118 SER 118 118 118 SER SER A . n 
A 1 119 THR 119 119 119 THR THR A . n 
A 1 120 ILE 120 120 120 ILE ILE A . n 
A 1 121 VAL 121 121 121 VAL VAL A . n 
A 1 122 THR 122 122 122 THR THR A . n 
A 1 123 GLU 123 123 123 GLU GLU A . n 
A 1 124 TRP 124 124 124 TRP TRP A . n 
A 1 125 ASP 125 125 125 ASP ASP A . n 
A 1 126 LEU 126 126 126 LEU LEU A . n 
A 1 127 VAL 127 127 127 VAL VAL A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 SER 129 129 129 SER SER A . n 
A 1 130 HIS 130 130 130 HIS HIS A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 ALA 132 132 132 ALA ALA A . n 
A 1 133 LEU 133 133 133 LEU LEU A . n 
A 1 134 ARG 134 134 134 ARG ARG A . n 
A 1 135 GLN 135 135 135 GLN GLN A . n 
A 1 136 LEU 136 136 136 LEU LEU A . n 
A 1 137 ALA 137 137 137 ALA ALA A . n 
A 1 138 GLN 138 138 138 GLN GLN A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 LEU 140 140 140 LEU LEU A . n 
A 1 141 TYR 141 141 141 TYR TYR A . n 
A 1 142 MET 142 142 142 MET MET A . n 
A 1 143 VAL 143 143 143 VAL VAL A . n 
A 1 144 GLY 144 144 144 GLY GLY A . n 
A 1 145 VAL 145 145 145 VAL VAL A . n 
A 1 146 LEU 146 146 146 LEU LEU A . n 
A 1 147 LEU 147 147 147 LEU LEU A . n 
A 1 148 GLY 148 148 148 GLY GLY A . n 
A 1 149 ALA 149 149 149 ALA ALA A . n 
A 1 150 MET 150 150 150 MET MET A . n 
A 1 151 VAL 151 151 151 VAL VAL A . n 
A 1 152 PHE 152 152 152 PHE PHE A . n 
A 1 153 GLY 153 153 153 GLY GLY A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 LEU 155 155 155 LEU LEU A . n 
A 1 156 ALA 156 156 156 ALA ALA A . n 
A 1 157 ASP 157 157 157 ASP ASP A . n 
A 1 158 ARG 158 158 158 ARG ARG A . n 
A 1 159 LEU 159 159 159 LEU LEU A . n 
A 1 160 GLY 160 160 160 GLY GLY A . n 
A 1 161 ARG 161 161 161 ARG ARG A . n 
A 1 162 ARG 162 162 162 ARG ARG A . n 
A 1 163 LYS 163 163 163 LYS LYS A . n 
A 1 164 VAL 164 164 164 VAL VAL A . n 
A 1 165 LEU 165 165 165 LEU LEU A . n 
A 1 166 ILE 166 166 166 ILE ILE A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 ASN 168 168 168 ASN ASN A . n 
A 1 169 TYR 169 169 169 TYR TYR A . n 
A 1 170 LEU 170 170 170 LEU LEU A . n 
A 1 171 GLN 171 171 171 GLN GLN A . n 
A 1 172 THR 172 172 172 THR THR A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 VAL 174 174 174 VAL VAL A . n 
A 1 175 SER 175 175 175 SER SER A . n 
A 1 176 GLY 176 176 176 GLY GLY A . n 
A 1 177 THR 177 177 177 THR THR A . n 
A 1 178 CYS 178 178 178 CYS CYS A . n 
A 1 179 ALA 179 179 179 ALA ALA A . n 
A 1 180 ALA 180 180 180 ALA ALA A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 ALA 182 182 182 ALA ALA A . n 
A 1 183 PRO 183 183 183 PRO PRO A . n 
A 1 184 ASN 184 184 184 ASN ASN A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 PRO 186 186 186 PRO PRO A . n 
A 1 187 ILE 187 187 187 ILE ILE A . n 
A 1 188 TYR 188 188 188 TYR TYR A . n 
A 1 189 CYS 189 189 189 CYS CYS A . n 
A 1 190 ALA 190 190 190 ALA ALA A . n 
A 1 191 PHE 191 191 191 PHE PHE A . n 
A 1 192 ARG 192 192 192 ARG ARG A . n 
A 1 193 LEU 193 193 193 LEU LEU A . n 
A 1 194 LEU 194 194 194 LEU LEU A . n 
A 1 195 SER 195 195 195 SER SER A . n 
A 1 196 GLY 196 196 196 GLY GLY A . n 
A 1 197 MET 197 197 197 MET MET A . n 
A 1 198 ALA 198 198 198 ALA ALA A . n 
A 1 199 LEU 199 199 199 LEU LEU A . n 
A 1 200 ALA 200 200 200 ALA ALA A . n 
A 1 201 GLY 201 201 201 GLY GLY A . n 
A 1 202 ILE 202 202 202 ILE ILE A . n 
A 1 203 SER 203 203 203 SER SER A . n 
A 1 204 LEU 204 204 204 LEU LEU A . n 
A 1 205 ASN 205 205 205 ASN ASN A . n 
A 1 206 CYS 206 206 206 CYS CYS A . n 
A 1 207 MET 207 207 207 MET MET A . n 
A 1 208 THR 208 208 208 THR THR A . n 
A 1 209 LEU 209 209 209 LEU LEU A . n 
A 1 210 ASN 210 210 210 ASN ASN A . n 
A 1 211 VAL 211 211 211 VAL VAL A . n 
A 1 212 GLU 212 212 212 GLU GLU A . n 
A 1 213 TRP 213 213 213 TRP TRP A . n 
A 1 214 MET 214 214 214 MET MET A . n 
A 1 215 PRO 215 215 215 PRO PRO A . n 
A 1 216 ILE 216 216 216 ILE ILE A . n 
A 1 217 HIS 217 217 217 HIS HIS A . n 
A 1 218 THR 218 218 218 THR THR A . n 
A 1 219 ARG 219 219 219 ARG ARG A . n 
A 1 220 ALA 220 220 220 ALA ALA A . n 
A 1 221 CYS 221 221 221 CYS CYS A . n 
A 1 222 VAL 222 222 222 VAL VAL A . n 
A 1 223 GLY 223 223 223 GLY GLY A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 LEU 225 225 225 LEU LEU A . n 
A 1 226 ILE 226 226 226 ILE ILE A . n 
A 1 227 GLY 227 227 227 GLY GLY A . n 
A 1 228 TYR 228 228 228 TYR TYR A . n 
A 1 229 VAL 229 229 229 VAL VAL A . n 
A 1 230 TYR 230 230 230 TYR TYR A . n 
A 1 231 SER 231 231 231 SER SER A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 GLY 233 233 233 GLY GLY A . n 
A 1 234 GLN 234 234 234 GLN GLN A . n 
A 1 235 PHE 235 235 235 PHE PHE A . n 
A 1 236 LEU 236 236 236 LEU LEU A . n 
A 1 237 LEU 237 237 237 LEU LEU A . n 
A 1 238 ALA 238 238 238 ALA ALA A . n 
A 1 239 GLY 239 239 239 GLY GLY A . n 
A 1 240 VAL 240 240 240 VAL VAL A . n 
A 1 241 ALA 241 241 241 ALA ALA A . n 
A 1 242 TYR 242 242 242 TYR TYR A . n 
A 1 243 ALA 243 243 243 ALA ALA A . n 
A 1 244 VAL 244 244 244 VAL VAL A . n 
A 1 245 PRO 245 245 245 PRO PRO A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 TRP 247 247 247 TRP TRP A . n 
A 1 248 ARG 248 248 248 ARG ARG A . n 
A 1 249 HIS 249 249 249 HIS HIS A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLN 251 251 251 GLN GLN A . n 
A 1 252 LEU 252 252 252 LEU LEU A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 VAL 254 254 254 VAL VAL A . n 
A 1 255 SER 255 255 255 SER SER A . n 
A 1 256 ALA 256 256 256 ALA ALA A . n 
A 1 257 PRO 257 257 257 PRO PRO A . n 
A 1 258 PHE 258 258 258 PHE PHE A . n 
A 1 259 PHE 259 259 259 PHE PHE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 PHE 261 261 261 PHE PHE A . n 
A 1 262 PHE 262 262 262 PHE PHE A . n 
A 1 263 ILE 263 263 263 ILE ILE A . n 
A 1 264 TYR 264 264 264 TYR TYR A . n 
A 1 265 SER 265 265 265 SER SER A . n 
A 1 266 TRP 266 266 266 TRP TRP A . n 
A 1 267 PHE 267 267 267 PHE PHE A . n 
A 1 268 PHE 268 268 268 PHE PHE A . n 
A 1 269 ILE 269 269 269 ILE ILE A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 SER 271 271 271 SER SER A . n 
A 1 272 ALA 272 272 272 ALA ALA A . n 
A 1 273 ARG 273 273 273 ARG ARG A . n 
A 1 274 TRP 274 274 274 TRP TRP A . n 
A 1 275 HIS 275 275 275 HIS HIS A . n 
A 1 276 SER 276 276 276 SER SER A . n 
A 1 277 SER 277 277 277 SER SER A . n 
A 1 278 SER 278 278 278 SER SER A . n 
A 1 279 GLY 279 279 279 GLY GLY A . n 
A 1 280 ARG 280 280 280 ARG ARG A . n 
A 1 281 LEU 281 281 281 LEU LEU A . n 
A 1 282 ASP 282 282 282 ASP ASP A . n 
A 1 283 LEU 283 283 283 LEU LEU A . n 
A 1 284 THR 284 284 284 THR THR A . n 
A 1 285 LEU 285 285 285 LEU LEU A . n 
A 1 286 ARG 286 286 286 ARG ARG A . n 
A 1 287 ALA 287 287 287 ALA ALA A . n 
A 1 288 LEU 288 288 288 LEU LEU A . n 
A 1 289 GLN 289 289 289 GLN GLN A . n 
A 1 290 ARG 290 290 290 ARG ARG A . n 
A 1 291 VAL 291 291 291 VAL VAL A . n 
A 1 292 ALA 292 292 292 ALA ALA A . n 
A 1 293 ARG 293 293 293 ARG ARG A . n 
A 1 294 ILE 294 294 294 ILE ILE A . n 
A 1 295 ASN 295 295 295 ASN ASN A . n 
A 1 296 GLY 296 296 296 GLY GLY A . n 
A 1 297 LYS 297 297 297 LYS LYS A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLU 299 299 299 GLU GLU A . n 
A 1 300 GLU 300 300 300 GLU GLU A . n 
A 1 301 GLY 301 301 301 GLY GLY A . n 
A 1 302 ALA 302 302 302 ALA ALA A . n 
A 1 303 LYS 303 303 303 LYS LYS A . n 
A 1 304 LEU 304 304 304 LEU LEU A . n 
A 1 305 SER 305 305 305 SER SER A . n 
A 1 306 MET 306 306 306 MET MET A . n 
A 1 307 GLU 307 307 307 GLU GLU A . n 
A 1 308 VAL 308 308 308 VAL VAL A . n 
A 1 309 LEU 309 309 309 LEU LEU A . n 
A 1 310 ARG 310 310 310 ARG ARG A . n 
A 1 311 ALA 311 311 311 ALA ALA A . n 
A 1 312 SER 312 312 312 SER SER A . n 
A 1 313 LEU 313 313 313 LEU LEU A . n 
A 1 314 GLN 314 314 314 GLN GLN A . n 
A 1 315 LYS 315 315 315 LYS LYS A . n 
A 1 316 GLU 316 316 316 GLU GLU A . n 
A 1 317 LEU 317 317 317 LEU LEU A . n 
A 1 318 THR 318 318 ?   ?   ?   A . n 
A 1 319 MET 319 319 ?   ?   ?   A . n 
A 1 320 GLY 320 320 ?   ?   ?   A . n 
A 1 321 LYS 321 321 ?   ?   ?   A . n 
A 1 322 GLY 322 322 ?   ?   ?   A . n 
A 1 323 GLN 323 323 323 GLN GLN A . n 
A 1 324 ALA 324 324 324 ALA ALA A . n 
A 1 325 SER 325 325 325 SER SER A . n 
A 1 326 ALA 326 326 326 ALA ALA A . n 
A 1 327 MET 327 327 327 MET MET A . n 
A 1 328 GLU 328 328 328 GLU GLU A . n 
A 1 329 LEU 329 329 329 LEU LEU A . n 
A 1 330 LEU 330 330 330 LEU LEU A . n 
A 1 331 ARG 331 331 331 ARG ARG A . n 
A 1 332 CYS 332 332 332 CYS CYS A . n 
A 1 333 PRO 333 333 333 PRO PRO A . n 
A 1 334 THR 334 334 334 THR THR A . n 
A 1 335 LEU 335 335 335 LEU LEU A . n 
A 1 336 ARG 336 336 336 ARG ARG A . n 
A 1 337 HIS 337 337 337 HIS HIS A . n 
A 1 338 LEU 338 338 338 LEU LEU A . n 
A 1 339 PHE 339 339 339 PHE PHE A . n 
A 1 340 LEU 340 340 340 LEU LEU A . n 
A 1 341 CYS 341 341 341 CYS CYS A . n 
A 1 342 LEU 342 342 342 LEU LEU A . n 
A 1 343 SER 343 343 343 SER SER A . n 
A 1 344 MET 344 344 344 MET MET A . n 
A 1 345 LEU 345 345 345 LEU LEU A . n 
A 1 346 TRP 346 346 346 TRP TRP A . n 
A 1 347 PHE 347 347 347 PHE PHE A . n 
A 1 348 ALA 348 348 348 ALA ALA A . n 
A 1 349 THR 349 349 349 THR THR A . n 
A 1 350 SER 350 350 350 SER SER A . n 
A 1 351 PHE 351 351 351 PHE PHE A . n 
A 1 352 ALA 352 352 352 ALA ALA A . n 
A 1 353 TYR 353 353 353 TYR TYR A . n 
A 1 354 TYR 354 354 354 TYR TYR A . n 
A 1 355 GLY 355 355 355 GLY GLY A . n 
A 1 356 LEU 356 356 356 LEU LEU A . n 
A 1 357 VAL 357 357 357 VAL VAL A . n 
A 1 358 MET 358 358 358 MET MET A . n 
A 1 359 ASP 359 359 359 ASP ASP A . n 
A 1 360 LEU 360 360 360 LEU LEU A . n 
A 1 361 GLN 361 361 361 GLN GLN A . n 
A 1 362 GLY 362 362 362 GLY GLY A . n 
A 1 363 PHE 363 363 363 PHE PHE A . n 
A 1 364 GLY 364 364 364 GLY GLY A . n 
A 1 365 VAL 365 365 365 VAL VAL A . n 
A 1 366 SER 366 366 366 SER SER A . n 
A 1 367 ILE 367 367 367 ILE ILE A . n 
A 1 368 TYR 368 368 368 TYR TYR A . n 
A 1 369 LEU 369 369 369 LEU LEU A . n 
A 1 370 ILE 370 370 370 ILE ILE A . n 
A 1 371 GLN 371 371 371 GLN GLN A . n 
A 1 372 VAL 372 372 372 VAL VAL A . n 
A 1 373 ILE 373 373 373 ILE ILE A . n 
A 1 374 PHE 374 374 374 PHE PHE A . n 
A 1 375 GLY 375 375 375 GLY GLY A . n 
A 1 376 ALA 376 376 376 ALA ALA A . n 
A 1 377 VAL 377 377 377 VAL VAL A . n 
A 1 378 ASP 378 378 378 ASP ASP A . n 
A 1 379 LEU 379 379 379 LEU LEU A . n 
A 1 380 PRO 380 380 380 PRO PRO A . n 
A 1 381 ALA 381 381 381 ALA ALA A . n 
A 1 382 LYS 382 382 382 LYS LYS A . n 
A 1 383 LEU 383 383 383 LEU LEU A . n 
A 1 384 VAL 384 384 384 VAL VAL A . n 
A 1 385 GLY 385 385 385 GLY GLY A . n 
A 1 386 PHE 386 386 386 PHE PHE A . n 
A 1 387 LEU 387 387 387 LEU LEU A . n 
A 1 388 VAL 388 388 388 VAL VAL A . n 
A 1 389 ILE 389 389 389 ILE ILE A . n 
A 1 390 ASN 390 390 390 ASN ASN A . n 
A 1 391 SER 391 391 391 SER SER A . n 
A 1 392 LEU 392 392 392 LEU LEU A . n 
A 1 393 GLY 393 393 393 GLY GLY A . n 
A 1 394 ARG 394 394 394 ARG ARG A . n 
A 1 395 ARG 395 395 395 ARG ARG A . n 
A 1 396 PRO 396 396 396 PRO PRO A . n 
A 1 397 ALA 397 397 397 ALA ALA A . n 
A 1 398 GLN 398 398 398 GLN GLN A . n 
A 1 399 MET 399 399 399 MET MET A . n 
A 1 400 ALA 400 400 400 ALA ALA A . n 
A 1 401 ALA 401 401 401 ALA ALA A . n 
A 1 402 LEU 402 402 402 LEU LEU A . n 
A 1 403 LEU 403 403 403 LEU LEU A . n 
A 1 404 LEU 404 404 404 LEU LEU A . n 
A 1 405 ALA 405 405 405 ALA ALA A . n 
A 1 406 GLY 406 406 406 GLY GLY A . n 
A 1 407 ILE 407 407 407 ILE ILE A . n 
A 1 408 CYS 408 408 408 CYS CYS A . n 
A 1 409 ILE 409 409 409 ILE ILE A . n 
A 1 410 LEU 410 410 410 LEU LEU A . n 
A 1 411 LEU 411 411 411 LEU LEU A . n 
A 1 412 ASN 412 412 412 ASN ASN A . n 
A 1 413 GLY 413 413 413 GLY GLY A . n 
A 1 414 VAL 414 414 414 VAL VAL A . n 
A 1 415 ILE 415 415 415 ILE ILE A . n 
A 1 416 PRO 416 416 416 PRO PRO A . n 
A 1 417 GLN 417 417 417 GLN GLN A . n 
A 1 418 ASP 418 418 418 ASP ASP A . n 
A 1 419 GLN 419 419 419 GLN GLN A . n 
A 1 420 SER 420 420 420 SER SER A . n 
A 1 421 ILE 421 421 421 ILE ILE A . n 
A 1 422 VAL 422 422 422 VAL VAL A . n 
A 1 423 ARG 423 423 423 ARG ARG A . n 
A 1 424 THR 424 424 424 THR THR A . n 
A 1 425 SER 425 425 425 SER SER A . n 
A 1 426 LEU 426 426 426 LEU LEU A . n 
A 1 427 ALA 427 427 427 ALA ALA A . n 
A 1 428 VAL 428 428 428 VAL VAL A . n 
A 1 429 LEU 429 429 429 LEU LEU A . n 
A 1 430 GLY 430 430 430 GLY GLY A . n 
A 1 431 LYS 431 431 431 LYS LYS A . n 
A 1 432 GLY 432 432 432 GLY GLY A . n 
A 1 433 CYS 433 433 433 CYS CYS A . n 
A 1 434 LEU 434 434 434 LEU LEU A . n 
A 1 435 ALA 435 435 435 ALA ALA A . n 
A 1 436 ALA 436 436 436 ALA ALA A . n 
A 1 437 SER 437 437 437 SER SER A . n 
A 1 438 PHE 438 438 438 PHE PHE A . n 
A 1 439 ASN 439 439 439 ASN ASN A . n 
A 1 440 CYS 440 440 440 CYS CYS A . n 
A 1 441 ILE 441 441 441 ILE ILE A . n 
A 1 442 PHE 442 442 442 PHE PHE A . n 
A 1 443 LEU 443 443 443 LEU LEU A . n 
A 1 444 TYR 444 444 444 TYR TYR A . n 
A 1 445 THR 445 445 445 THR THR A . n 
A 1 446 GLY 446 446 446 GLY GLY A . n 
A 1 447 GLU 447 447 447 GLU GLU A . n 
A 1 448 LEU 448 448 448 LEU LEU A . n 
A 1 449 TYR 449 449 449 TYR TYR A . n 
A 1 450 PRO 450 450 450 PRO PRO A . n 
A 1 451 THR 451 451 451 THR THR A . n 
A 1 452 MET 452 452 452 MET MET A . n 
A 1 453 ILE 453 453 453 ILE ILE A . n 
A 1 454 ARG 454 454 454 ARG ARG A . n 
A 1 455 GLN 455 455 455 GLN GLN A . n 
A 1 456 THR 456 456 456 THR THR A . n 
A 1 457 GLY 457 457 457 GLY GLY A . n 
A 1 458 MET 458 458 458 MET MET A . n 
A 1 459 GLY 459 459 459 GLY GLY A . n 
A 1 460 MET 460 460 460 MET MET A . n 
A 1 461 GLY 461 461 461 GLY GLY A . n 
A 1 462 SER 462 462 462 SER SER A . n 
A 1 463 THR 463 463 463 THR THR A . n 
A 1 464 MET 464 464 464 MET MET A . n 
A 1 465 ALA 465 465 465 ALA ALA A . n 
A 1 466 ARG 466 466 466 ARG ARG A . n 
A 1 467 VAL 467 467 467 VAL VAL A . n 
A 1 468 GLY 468 468 468 GLY GLY A . n 
A 1 469 SER 469 469 469 SER SER A . n 
A 1 470 ILE 470 470 470 ILE ILE A . n 
A 1 471 VAL 471 471 471 VAL VAL A . n 
A 1 472 SER 472 472 472 SER SER A . n 
A 1 473 PRO 473 473 473 PRO PRO A . n 
A 1 474 LEU 474 474 474 LEU LEU A . n 
A 1 475 VAL 475 475 475 VAL VAL A . n 
A 1 476 SER 476 476 476 SER SER A . n 
A 1 477 MET 477 477 477 MET MET A . n 
A 1 478 THR 478 478 478 THR THR A . n 
A 1 479 ALA 479 479 479 ALA ALA A . n 
A 1 480 GLU 480 480 480 GLU GLU A . n 
A 1 481 LEU 481 481 481 LEU LEU A . n 
A 1 482 TYR 482 482 482 TYR TYR A . n 
A 1 483 PRO 483 483 483 PRO PRO A . n 
A 1 484 SER 484 484 484 SER SER A . n 
A 1 485 MET 485 485 485 MET MET A . n 
A 1 486 PRO 486 486 486 PRO PRO A . n 
A 1 487 LEU 487 487 487 LEU LEU A . n 
A 1 488 PHE 488 488 488 PHE PHE A . n 
A 1 489 ILE 489 489 489 ILE ILE A . n 
A 1 490 TYR 490 490 490 TYR TYR A . n 
A 1 491 GLY 491 491 491 GLY GLY A . n 
A 1 492 ALA 492 492 492 ALA ALA A . n 
A 1 493 VAL 493 493 493 VAL VAL A . n 
A 1 494 PRO 494 494 494 PRO PRO A . n 
A 1 495 VAL 495 495 495 VAL VAL A . n 
A 1 496 ALA 496 496 496 ALA ALA A . n 
A 1 497 ALA 497 497 497 ALA ALA A . n 
A 1 498 SER 498 498 498 SER SER A . n 
A 1 499 ALA 499 499 499 ALA ALA A . n 
A 1 500 VAL 500 500 500 VAL VAL A . n 
A 1 501 THR 501 501 501 THR THR A . n 
A 1 502 VAL 502 502 502 VAL VAL A . n 
A 1 503 LEU 503 503 503 LEU LEU A . n 
A 1 504 LEU 504 504 504 LEU LEU A . n 
A 1 505 PRO 505 505 505 PRO PRO A . n 
A 1 506 GLU 506 506 506 GLU GLU A . n 
A 1 507 THR 507 507 507 THR THR A . n 
A 1 508 LEU 508 508 508 LEU LEU A . n 
A 1 509 GLY 509 509 509 GLY GLY A . n 
A 1 510 GLN 510 510 510 GLN GLN A . n 
A 1 511 PRO 511 511 511 PRO PRO A . n 
A 1 512 LEU 512 512 512 LEU LEU A . n 
A 1 513 PRO 513 513 513 PRO PRO A . n 
A 1 514 ASP 514 514 514 ASP ASP A . n 
A 1 515 THR 515 515 515 THR THR A . n 
A 1 516 VAL 516 516 516 VAL VAL A . n 
A 1 517 GLN 517 517 517 GLN GLN A . n 
A 1 518 ASP 518 518 518 ASP ASP A . n 
A 1 519 LEU 519 519 519 LEU LEU A . n 
A 1 520 GLU 520 520 520 GLU GLU A . n 
A 1 521 SER 521 521 521 SER SER A . n 
A 1 522 ARG 522 522 522 ARG ARG A . n 
A 1 523 LYS 523 523 ?   ?   ?   A . n 
A 1 524 GLY 524 524 ?   ?   ?   A . n 
A 1 525 LYS 525 525 ?   ?   ?   A . n 
A 1 526 GLN 526 526 ?   ?   ?   A . n 
A 1 527 THR 527 527 ?   ?   ?   A . n 
A 1 528 ARG 528 528 ?   ?   ?   A . n 
A 1 529 GLN 529 529 ?   ?   ?   A . n 
A 1 530 GLN 530 530 ?   ?   ?   A . n 
A 1 531 GLN 531 531 ?   ?   ?   A . n 
A 1 532 GLU 532 532 ?   ?   ?   A . n 
A 1 533 HIS 533 533 ?   ?   ?   A . n 
A 1 534 GLN 534 534 ?   ?   ?   A . n 
A 1 535 LYS 535 535 ?   ?   ?   A . n 
A 1 536 TYR 536 536 ?   ?   ?   A . n 
A 1 537 MET 537 537 ?   ?   ?   A . n 
A 1 538 VAL 538 538 ?   ?   ?   A . n 
A 1 539 PRO 539 539 ?   ?   ?   A . n 
A 1 540 LEU 540 540 ?   ?   ?   A . n 
A 1 541 GLN 541 541 ?   ?   ?   A . n 
A 1 542 ALA 542 542 ?   ?   ?   A . n 
A 1 543 SER 543 543 ?   ?   ?   A . n 
A 1 544 ALA 544 544 ?   ?   ?   A . n 
A 1 545 GLN 545 545 ?   ?   ?   A . n 
A 1 546 GLU 546 546 ?   ?   ?   A . n 
A 1 547 LYS 547 547 ?   ?   ?   A . n 
A 1 548 ASN 548 548 ?   ?   ?   A . n 
A 1 549 GLY 549 549 ?   ?   ?   A . n 
A 1 550 LEU 550 550 ?   ?   ?   A . n 
A 1 551 HIS 551 551 ?   ?   ?   A . n 
A 1 552 HIS 552 552 ?   ?   ?   A . n 
A 1 553 HIS 553 553 ?   ?   ?   A . n 
A 1 554 HIS 554 554 ?   ?   ?   A . n 
A 1 555 HIS 555 555 ?   ?   ?   A . n 
A 1 556 HIS 556 556 ?   ?   ?   A . n 
A 1 557 HIS 557 557 ?   ?   ?   A . n 
A 1 558 HIS 558 558 ?   ?   ?   A . n 
A 1 559 HIS 559 559 ?   ?   ?   A . n 
A 1 560 HIS 560 560 ?   ?   ?   A . n 
A 1 561 GLY 561 561 ?   ?   ?   A . n 
A 1 562 SER 562 562 ?   ?   ?   A . n 
A 1 563 VAL 563 563 ?   ?   ?   A . n 
A 1 564 GLU 564 564 ?   ?   ?   A . n 
A 1 565 ASP 565 565 ?   ?   ?   A . n 
A 1 566 TYR 566 566 ?   ?   ?   A . n 
A 1 567 LYS 567 567 ?   ?   ?   A . n 
A 1 568 ASP 568 568 ?   ?   ?   A . n 
A 1 569 ASP 569 569 ?   ?   ?   A . n 
A 1 570 ASP 570 570 ?   ?   ?   A . n 
A 1 571 ASP 571 571 ?   ?   ?   A . n 
A 1 572 LYS 572 572 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        ZWD 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   ZWD 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
_pdbx_nonpoly_scheme.asym_id         B 
_pdbx_nonpoly_scheme.entity_id       2 
_pdbx_nonpoly_scheme.mon_id          ZWD 
_pdbx_nonpoly_scheme.ndb_seq_num     1 
_pdbx_nonpoly_scheme.pdb_seq_num     601 
_pdbx_nonpoly_scheme.auth_seq_num    1 
_pdbx_nonpoly_scheme.pdb_mon_id      ZWD 
_pdbx_nonpoly_scheme.auth_mon_id     PAH 
_pdbx_nonpoly_scheme.pdb_strand_id   A 
_pdbx_nonpoly_scheme.pdb_ins_code    . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A GLU 64  ? CG  ? A GLU 64  CG  
2  1 Y 1 A GLU 64  ? CD  ? A GLU 64  CD  
3  1 Y 1 A GLU 64  ? OE1 ? A GLU 64  OE1 
4  1 Y 1 A GLU 64  ? OE2 ? A GLU 64  OE2 
5  1 Y 1 A TRP 66  ? CG  ? A TRP 66  CG  
6  1 Y 1 A TRP 66  ? CD1 ? A TRP 66  CD1 
7  1 Y 1 A TRP 66  ? CD2 ? A TRP 66  CD2 
8  1 Y 1 A TRP 66  ? NE1 ? A TRP 66  NE1 
9  1 Y 1 A TRP 66  ? CE2 ? A TRP 66  CE2 
10 1 Y 1 A TRP 66  ? CE3 ? A TRP 66  CE3 
11 1 Y 1 A TRP 66  ? CZ2 ? A TRP 66  CZ2 
12 1 Y 1 A TRP 66  ? CZ3 ? A TRP 66  CZ3 
13 1 Y 1 A TRP 66  ? CH2 ? A TRP 66  CH2 
14 1 Y 1 A LEU 67  ? CG  ? A LEU 67  CG  
15 1 Y 1 A LEU 67  ? CD1 ? A LEU 67  CD1 
16 1 Y 1 A LEU 67  ? CD2 ? A LEU 67  CD2 
17 1 Y 1 A ARG 69  ? CG  ? A ARG 69  CG  
18 1 Y 1 A ARG 69  ? CD  ? A ARG 69  CD  
19 1 Y 1 A ARG 69  ? NE  ? A ARG 69  NE  
20 1 Y 1 A ARG 69  ? CZ  ? A ARG 69  CZ  
21 1 Y 1 A ARG 69  ? NH1 ? A ARG 69  NH1 
22 1 Y 1 A ARG 69  ? NH2 ? A ARG 69  NH2 
23 1 Y 1 A ARG 71  ? CG  ? A ARG 71  CG  
24 1 Y 1 A ARG 71  ? CD  ? A ARG 71  CD  
25 1 Y 1 A ARG 71  ? NE  ? A ARG 71  NE  
26 1 Y 1 A ARG 71  ? CZ  ? A ARG 71  CZ  
27 1 Y 1 A ARG 71  ? NH1 ? A ARG 71  NH1 
28 1 Y 1 A ARG 71  ? NH2 ? A ARG 71  NH2 
29 1 Y 1 A GLN 72  ? CG  ? A GLN 72  CG  
30 1 Y 1 A GLN 72  ? CD  ? A GLN 72  CD  
31 1 Y 1 A GLN 72  ? OE1 ? A GLN 72  OE1 
32 1 Y 1 A GLN 72  ? NE2 ? A GLN 72  NE2 
33 1 Y 1 A GLU 76  ? CG  ? A GLU 76  CG  
34 1 Y 1 A GLU 76  ? CD  ? A GLU 76  CD  
35 1 Y 1 A GLU 76  ? OE1 ? A GLU 76  OE1 
36 1 Y 1 A GLU 76  ? OE2 ? A GLU 76  OE2 
37 1 Y 1 A GLU 103 ? CG  ? A GLU 103 CG  
38 1 Y 1 A GLU 103 ? CD  ? A GLU 103 CD  
39 1 Y 1 A GLU 103 ? OE1 ? A GLU 103 OE1 
40 1 Y 1 A GLU 103 ? OE2 ? A GLU 103 OE2 
41 1 Y 1 A ARG 286 ? CG  ? A ARG 286 CG  
42 1 Y 1 A ARG 286 ? CD  ? A ARG 286 CD  
43 1 Y 1 A ARG 286 ? NE  ? A ARG 286 NE  
44 1 Y 1 A ARG 286 ? CZ  ? A ARG 286 CZ  
45 1 Y 1 A ARG 286 ? NH1 ? A ARG 286 NH1 
46 1 Y 1 A ARG 286 ? NH2 ? A ARG 286 NH2 
47 1 Y 1 A ARG 293 ? CG  ? A ARG 293 CG  
48 1 Y 1 A ARG 293 ? CD  ? A ARG 293 CD  
49 1 Y 1 A ARG 293 ? NE  ? A ARG 293 NE  
50 1 Y 1 A ARG 293 ? CZ  ? A ARG 293 CZ  
51 1 Y 1 A ARG 293 ? NH1 ? A ARG 293 NH1 
52 1 Y 1 A ARG 293 ? NH2 ? A ARG 293 NH2 
53 1 Y 1 A ARG 298 ? CG  ? A ARG 298 CG  
54 1 Y 1 A ARG 298 ? CD  ? A ARG 298 CD  
55 1 Y 1 A ARG 298 ? NE  ? A ARG 298 NE  
56 1 Y 1 A ARG 298 ? CZ  ? A ARG 298 CZ  
57 1 Y 1 A ARG 298 ? NH1 ? A ARG 298 NH1 
58 1 Y 1 A ARG 298 ? NH2 ? A ARG 298 NH2 
59 1 Y 1 A GLU 307 ? CG  ? A GLU 307 CG  
60 1 Y 1 A GLU 307 ? CD  ? A GLU 307 CD  
61 1 Y 1 A GLU 307 ? OE1 ? A GLU 307 OE1 
62 1 Y 1 A GLU 307 ? OE2 ? A GLU 307 OE2 
63 1 Y 1 A GLN 314 ? CG  ? A GLN 314 CG  
64 1 Y 1 A GLN 314 ? CD  ? A GLN 314 CD  
65 1 Y 1 A GLN 314 ? OE1 ? A GLN 314 OE1 
66 1 Y 1 A GLN 314 ? NE2 ? A GLN 314 NE2 
67 1 Y 1 A LYS 315 ? CG  ? A LYS 315 CG  
68 1 Y 1 A LYS 315 ? CD  ? A LYS 315 CD  
69 1 Y 1 A LYS 315 ? CE  ? A LYS 315 CE  
70 1 Y 1 A LYS 315 ? NZ  ? A LYS 315 NZ  
71 1 Y 1 A ARG 331 ? CG  ? A ARG 331 CG  
72 1 Y 1 A ARG 331 ? CD  ? A ARG 331 CD  
73 1 Y 1 A ARG 331 ? NE  ? A ARG 331 NE  
74 1 Y 1 A ARG 331 ? CZ  ? A ARG 331 CZ  
75 1 Y 1 A ARG 331 ? NH1 ? A ARG 331 NH1 
76 1 Y 1 A ARG 331 ? NH2 ? A ARG 331 NH2 
77 1 Y 1 A VAL 516 ? CG1 ? A VAL 516 CG1 
78 1 Y 1 A VAL 516 ? CG2 ? A VAL 516 CG2 
79 1 Y 1 A GLU 520 ? CG  ? A GLU 520 CG  
80 1 Y 1 A GLU 520 ? CD  ? A GLU 520 CD  
81 1 Y 1 A GLU 520 ? OE1 ? A GLU 520 OE1 
82 1 Y 1 A GLU 520 ? OE2 ? A GLU 520 OE2 
83 1 Y 1 A SER 521 ? OG  ? A SER 521 OG  
84 1 Y 1 A ARG 522 ? CG  ? A ARG 522 CG  
85 1 Y 1 A ARG 522 ? CD  ? A ARG 522 CD  
86 1 Y 1 A ARG 522 ? NE  ? A ARG 522 NE  
87 1 Y 1 A ARG 522 ? CZ  ? A ARG 522 CZ  
88 1 Y 1 A ARG 522 ? NH1 ? A ARG 522 NH1 
89 1 Y 1 A ARG 522 ? NH2 ? A ARG 522 NH2 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9MC8 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9MC8 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9MC8 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     9MC8 
_struct.title                        'Cryo-EM structure of human OAT1 in complex with PAH' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9MC8 
_struct_keywords.text            'transporter, OAT1, organic anion transporter, MEMBRANE PROTEIN' 
_struct_keywords.pdbx_keywords   'MEMBRANE PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    S22A6_HUMAN 
_struct_ref.pdbx_db_accession          Q4U2R8 
_struct_ref.pdbx_db_isoform            Q4U2R8-2 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEVWLPRDRQGQPESCLR
FTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLG
RRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV
AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMG
KGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMA
ALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAE
LYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRKGKQTRQQQEHQKYMVPLQASAQEKNGL
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9MC8 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 550 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q4U2R8 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  550 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       550 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9MC8 HIS A 551 ? UNP Q4U2R8 ? ? 'expression tag' 551 1  
1 9MC8 HIS A 552 ? UNP Q4U2R8 ? ? 'expression tag' 552 2  
1 9MC8 HIS A 553 ? UNP Q4U2R8 ? ? 'expression tag' 553 3  
1 9MC8 HIS A 554 ? UNP Q4U2R8 ? ? 'expression tag' 554 4  
1 9MC8 HIS A 555 ? UNP Q4U2R8 ? ? 'expression tag' 555 5  
1 9MC8 HIS A 556 ? UNP Q4U2R8 ? ? 'expression tag' 556 6  
1 9MC8 HIS A 557 ? UNP Q4U2R8 ? ? 'expression tag' 557 7  
1 9MC8 HIS A 558 ? UNP Q4U2R8 ? ? 'expression tag' 558 8  
1 9MC8 HIS A 559 ? UNP Q4U2R8 ? ? 'expression tag' 559 9  
1 9MC8 HIS A 560 ? UNP Q4U2R8 ? ? 'expression tag' 560 10 
1 9MC8 GLY A 561 ? UNP Q4U2R8 ? ? 'expression tag' 561 11 
1 9MC8 SER A 562 ? UNP Q4U2R8 ? ? 'expression tag' 562 12 
1 9MC8 VAL A 563 ? UNP Q4U2R8 ? ? 'expression tag' 563 13 
1 9MC8 GLU A 564 ? UNP Q4U2R8 ? ? 'expression tag' 564 14 
1 9MC8 ASP A 565 ? UNP Q4U2R8 ? ? 'expression tag' 565 15 
1 9MC8 TYR A 566 ? UNP Q4U2R8 ? ? 'expression tag' 566 16 
1 9MC8 LYS A 567 ? UNP Q4U2R8 ? ? 'expression tag' 567 17 
1 9MC8 ASP A 568 ? UNP Q4U2R8 ? ? 'expression tag' 568 18 
1 9MC8 ASP A 569 ? UNP Q4U2R8 ? ? 'expression tag' 569 19 
1 9MC8 ASP A 570 ? UNP Q4U2R8 ? ? 'expression tag' 570 20 
1 9MC8 ASP A 571 ? UNP Q4U2R8 ? ? 'expression tag' 571 21 
1 9MC8 LYS A 572 ? UNP Q4U2R8 ? ? 'expression tag' 572 22 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PHE A 3   ? VAL A 10  ? PHE A 3   VAL A 10  1 ? 8  
HELX_P HELX_P2  AA2 GLY A 14  ? LEU A 26  ? GLY A 14  LEU A 26  1 ? 13 
HELX_P HELX_P3  AA3 PRO A 27  ? LEU A 29  ? PRO A 27  LEU A 29  5 ? 3  
HELX_P HELX_P4  AA4 LEU A 30  ? THR A 36  ? LEU A 30  THR A 36  1 ? 7  
HELX_P HELX_P5  AA5 LEU A 37  ? PHE A 40  ? LEU A 37  PHE A 40  5 ? 4  
HELX_P HELX_P6  AA6 THR A 119 ? TRP A 124 ? THR A 119 TRP A 124 1 ? 6  
HELX_P HELX_P7  AA7 VAL A 127 ? HIS A 130 ? VAL A 127 HIS A 130 5 ? 4  
HELX_P HELX_P8  AA8 ARG A 131 ? GLY A 160 ? ARG A 131 GLY A 160 1 ? 30 
HELX_P HELX_P9  AA9 GLY A 160 ? PHE A 181 ? GLY A 160 PHE A 181 1 ? 22 
HELX_P HELX_P10 AB1 ASN A 184 ? MET A 214 ? ASN A 184 MET A 214 1 ? 31 
HELX_P HELX_P11 AB2 PRO A 215 ? HIS A 217 ? PRO A 215 HIS A 217 5 ? 3  
HELX_P HELX_P12 AB3 THR A 218 ? VAL A 244 ? THR A 218 VAL A 244 1 ? 27 
HELX_P HELX_P13 AB4 HIS A 246 ? ALA A 256 ? HIS A 246 ALA A 256 1 ? 11 
HELX_P HELX_P14 AB5 ALA A 256 ? SER A 265 ? ALA A 256 SER A 265 1 ? 10 
HELX_P HELX_P15 AB6 TRP A 266 ? PHE A 268 ? TRP A 266 PHE A 268 5 ? 3  
HELX_P HELX_P16 AB7 SER A 271 ? GLY A 279 ? SER A 271 GLY A 279 1 ? 9  
HELX_P HELX_P17 AB8 ARG A 280 ? ASN A 295 ? ARG A 280 ASN A 295 1 ? 16 
HELX_P HELX_P18 AB9 LYS A 297 ? LEU A 304 ? LYS A 297 LEU A 304 1 ? 8  
HELX_P HELX_P19 AC1 SER A 305 ? GLN A 314 ? SER A 305 GLN A 314 1 ? 10 
HELX_P HELX_P20 AC2 ALA A 326 ? CYS A 332 ? ALA A 326 CYS A 332 1 ? 7  
HELX_P HELX_P21 AC3 CYS A 332 ? MET A 358 ? CYS A 332 MET A 358 1 ? 27 
HELX_P HELX_P22 AC4 LEU A 360 ? GLY A 364 ? LEU A 360 GLY A 364 5 ? 5  
HELX_P HELX_P23 AC5 SER A 366 ? LEU A 392 ? SER A 366 LEU A 392 1 ? 27 
HELX_P HELX_P24 AC6 ARG A 394 ? ILE A 415 ? ARG A 394 ILE A 415 1 ? 22 
HELX_P HELX_P25 AC7 GLN A 419 ? TYR A 449 ? GLN A 419 TYR A 449 1 ? 31 
HELX_P HELX_P26 AC8 ILE A 453 ? THR A 478 ? ILE A 453 THR A 478 1 ? 26 
HELX_P HELX_P27 AC9 ALA A 479 ? LEU A 481 ? ALA A 479 LEU A 481 5 ? 3  
HELX_P HELX_P28 AD1 SER A 484 ? VAL A 502 ? SER A 484 VAL A 502 1 ? 19 
HELX_P HELX_P29 AD2 THR A 515 ? ARG A 522 ? THR A 515 ARG A 522 1 ? 8  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 49 SG ? ? ? 1_555 A CYS 105 SG ? ? A CYS 49 A CYS 105 1_555 ? ? ? ? ? ? ? 2.025 ? ? 
disulf2 disulf ? ? A CYS 78 SG ? ? ? 1_555 A CYS 128 SG ? ? A CYS 78 A CYS 128 1_555 ? ? ? ? ? ? ? 2.030 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 49 ? CYS A 105 ? CYS A 49 ? 1_555 CYS A 105 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 78 ? CYS A 128 ? CYS A 78 ? 1_555 CYS A 128 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
_pdbx_entry_details.entry_id                   9MC8 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 CYS A 78  ? ? -117.17 51.93   
2 1 PHE A 116 ? ? 56.41   76.49   
3 1 CYS A 128 ? ? 45.67   -118.02 
4 1 MET A 150 ? ? -91.15  -62.63  
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9MC8 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9MC8 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.31 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               52099 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.4 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 OAT1 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        9MC8 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      2.7 
_em_imaging.nominal_defocus_min             900 
_em_imaging.nominal_defocus_max             1600 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           130000 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
_em_imaging.objective_aperture              ? 
_em_imaging.microscope_serial_number        ? 
_em_imaging.microscope_version              ? 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    GOLD 
_em_sample_support.grid_mesh_size   300 
_em_sample_support.grid_type        'Quantifoil R1.2/1.3' 
_em_sample_support.details          ? 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_vitrification.entry_id              9MC8 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   281 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9MC8 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A ALA 2   ? A ALA 2   
3  1 Y 1 A ASP 54  ? A ASP 54  
4  1 Y 1 A ALA 55  ? A ALA 55  
5  1 Y 1 A ASN 56  ? A ASN 56  
6  1 Y 1 A LEU 57  ? A LEU 57  
7  1 Y 1 A SER 58  ? A SER 58  
8  1 Y 1 A LYS 59  ? A LYS 59  
9  1 Y 1 A ASN 60  ? A ASN 60  
10 1 Y 1 A GLY 61  ? A GLY 61  
11 1 Y 1 A GLY 62  ? A GLY 62  
12 1 Y 1 A GLN 85  ? A GLN 85  
13 1 Y 1 A TRP 86  ? A TRP 86  
14 1 Y 1 A GLY 87  ? A GLY 87  
15 1 Y 1 A LEU 88  ? A LEU 88  
16 1 Y 1 A PRO 89  ? A PRO 89  
17 1 Y 1 A PHE 90  ? A PHE 90  
18 1 Y 1 A LEU 91  ? A LEU 91  
19 1 Y 1 A ASN 92  ? A ASN 92  
20 1 Y 1 A GLY 93  ? A GLY 93  
21 1 Y 1 A THR 94  ? A THR 94  
22 1 Y 1 A GLU 95  ? A GLU 95  
23 1 Y 1 A ALA 96  ? A ALA 96  
24 1 Y 1 A ASN 97  ? A ASN 97  
25 1 Y 1 A GLY 98  ? A GLY 98  
26 1 Y 1 A THR 99  ? A THR 99  
27 1 Y 1 A GLY 100 ? A GLY 100 
28 1 Y 1 A ALA 101 ? A ALA 101 
29 1 Y 1 A THR 318 ? A THR 318 
30 1 Y 1 A MET 319 ? A MET 319 
31 1 Y 1 A GLY 320 ? A GLY 320 
32 1 Y 1 A LYS 321 ? A LYS 321 
33 1 Y 1 A GLY 322 ? A GLY 322 
34 1 Y 1 A LYS 523 ? A LYS 523 
35 1 Y 1 A GLY 524 ? A GLY 524 
36 1 Y 1 A LYS 525 ? A LYS 525 
37 1 Y 1 A GLN 526 ? A GLN 526 
38 1 Y 1 A THR 527 ? A THR 527 
39 1 Y 1 A ARG 528 ? A ARG 528 
40 1 Y 1 A GLN 529 ? A GLN 529 
41 1 Y 1 A GLN 530 ? A GLN 530 
42 1 Y 1 A GLN 531 ? A GLN 531 
43 1 Y 1 A GLU 532 ? A GLU 532 
44 1 Y 1 A HIS 533 ? A HIS 533 
45 1 Y 1 A GLN 534 ? A GLN 534 
46 1 Y 1 A LYS 535 ? A LYS 535 
47 1 Y 1 A TYR 536 ? A TYR 536 
48 1 Y 1 A MET 537 ? A MET 537 
49 1 Y 1 A VAL 538 ? A VAL 538 
50 1 Y 1 A PRO 539 ? A PRO 539 
51 1 Y 1 A LEU 540 ? A LEU 540 
52 1 Y 1 A GLN 541 ? A GLN 541 
53 1 Y 1 A ALA 542 ? A ALA 542 
54 1 Y 1 A SER 543 ? A SER 543 
55 1 Y 1 A ALA 544 ? A ALA 544 
56 1 Y 1 A GLN 545 ? A GLN 545 
57 1 Y 1 A GLU 546 ? A GLU 546 
58 1 Y 1 A LYS 547 ? A LYS 547 
59 1 Y 1 A ASN 548 ? A ASN 548 
60 1 Y 1 A GLY 549 ? A GLY 549 
61 1 Y 1 A LEU 550 ? A LEU 550 
62 1 Y 1 A HIS 551 ? A HIS 551 
63 1 Y 1 A HIS 552 ? A HIS 552 
64 1 Y 1 A HIS 553 ? A HIS 553 
65 1 Y 1 A HIS 554 ? A HIS 554 
66 1 Y 1 A HIS 555 ? A HIS 555 
67 1 Y 1 A HIS 556 ? A HIS 556 
68 1 Y 1 A HIS 557 ? A HIS 557 
69 1 Y 1 A HIS 558 ? A HIS 558 
70 1 Y 1 A HIS 559 ? A HIS 559 
71 1 Y 1 A HIS 560 ? A HIS 560 
72 1 Y 1 A GLY 561 ? A GLY 561 
73 1 Y 1 A SER 562 ? A SER 562 
74 1 Y 1 A VAL 563 ? A VAL 563 
75 1 Y 1 A GLU 564 ? A GLU 564 
76 1 Y 1 A ASP 565 ? A ASP 565 
77 1 Y 1 A TYR 566 ? A TYR 566 
78 1 Y 1 A LYS 567 ? A LYS 567 
79 1 Y 1 A ASP 568 ? A ASP 568 
80 1 Y 1 A ASP 569 ? A ASP 569 
81 1 Y 1 A ASP 570 ? A ASP 570 
82 1 Y 1 A ASP 571 ? A ASP 571 
83 1 Y 1 A LYS 572 ? A LYS 572 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
ZWD C10  C N N 388 
ZWD C01  C Y N 389 
ZWD C02  C Y N 390 
ZWD C03  C Y N 391 
ZWD C04  C Y N 392 
ZWD C05  C Y N 393 
ZWD C06  C Y N 394 
ZWD C07  C N N 395 
ZWD C11  C N N 396 
ZWD N09  N N N 397 
ZWD N14  N N N 398 
ZWD O08  O N N 399 
ZWD O12  O N N 400 
ZWD O13  O N N 401 
ZWD H102 H N N 402 
ZWD H101 H N N 403 
ZWD H011 H N N 404 
ZWD H021 H N N 405 
ZWD H041 H N N 406 
ZWD H051 H N N 407 
ZWD H091 H N N 408 
ZWD H142 H N N 409 
ZWD H141 H N N 410 
ZWD H1   H N N 411 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
ZWD N14 C03  sing N N 374 
ZWD C04 C03  doub Y N 375 
ZWD C04 C05  sing Y N 376 
ZWD C03 C02  sing Y N 377 
ZWD C05 C06  doub Y N 378 
ZWD C02 C01  doub Y N 379 
ZWD C06 C01  sing Y N 380 
ZWD C06 C07  sing N N 381 
ZWD O13 C11  doub N N 382 
ZWD O12 C11  sing N N 383 
ZWD C11 C10  sing N N 384 
ZWD N09 C07  sing N N 385 
ZWD N09 C10  sing N N 386 
ZWD C07 O08  doub N N 387 
ZWD C10 H102 sing N N 388 
ZWD C10 H101 sing N N 389 
ZWD C01 H011 sing N N 390 
ZWD C02 H021 sing N N 391 
ZWD C04 H041 sing N N 392 
ZWD C05 H051 sing N N 393 
ZWD N09 H091 sing N N 394 
ZWD N14 H142 sing N N 395 
ZWD N14 H141 sing N N 396 
ZWD O12 H1   sing N N 397 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2025-03-17 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           9MC8 
_em_admin.last_update        2025-06-18 
_em_admin.map_release_date   2025-06-18 
_em_admin.title              'Cryo-EM structure of human OAT1 in complex with PAH' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     NONE 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                ? 
_em_entity_assembly_molwt.value                ? 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         49.6 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'FEI FALCON IV (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
_em_imaging_optics.chr_aberration_corrector   ? 
_em_imaging_optics.energyfilter_lower         ? 
_em_imaging_optics.energyfilter_slit_width    20 
_em_imaging_optics.energyfilter_name          'TFS Selectris X' 
_em_imaging_optics.energyfilter_upper         ? 
_em_imaging_optics.id                         1 
_em_imaging_optics.imaging_id                 1 
_em_imaging_optics.phase_plate                ? 
_em_imaging_optics.sph_aberration_corrector   ? 
_em_imaging_optics.details                    ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? ?   ? 
'IMAGE ACQUISITION'             ? 2  ? ? 1 EPU ? 
MASKING                         ? 3  ? ? ? ?   ? 
'CTF CORRECTION'                ? 4  1 ? ? ?   ? 
'LAYERLINE INDEXING'            ? 5  ? ? ? ?   ? 
'DIFFRACTION INDEXING'          ? 6  ? ? ? ?   ? 
'MODEL FITTING'                 ? 7  ? ? ? ?   ? 
'MODEL REFINEMENT'              ? 8  ? ? ? ?   ? 
OTHER                           ? 9  ? ? ? ?   ? 
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ?   ? 
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ?   ? 
CLASSIFICATION                  ? 12 1 ? ? ?   ? 
RECONSTRUCTION                  ? 13 1 ? ? ?   ? 
'VOLUME SELECTION'              ? 14 1 1 1 ?   ? 
'SERIES ALIGNMENT'              ? 15 1 1 1 ?   ? 
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ?   ? 
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ?   ? 
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ?   ? 
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ?   ? 
# 
_em_specimen.concentration           5 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    9MC8 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . PHE A 1 3   ? 138.845 111.758 97.888  1.00 189.08 ?  3   PHE A N   1 
ATOM   2    C CA  . PHE A 1 3   ? 137.796 111.739 96.878  1.00 189.25 ?  3   PHE A CA  1 
ATOM   3    C C   . PHE A 1 3   ? 137.068 113.061 96.837  1.00 189.63 ?  3   PHE A C   1 
ATOM   4    O O   . PHE A 1 3   ? 136.897 113.647 95.774  1.00 190.99 ?  3   PHE A O   1 
ATOM   5    C CB  . PHE A 1 3   ? 136.790 110.627 97.158  1.00 190.07 ?  3   PHE A CB  1 
ATOM   6    C CG  . PHE A 1 3   ? 135.634 110.605 96.202  1.00 188.79 ?  3   PHE A CG  1 
ATOM   7    C CD1 . PHE A 1 3   ? 135.761 110.015 94.957  1.00 187.77 ?  3   PHE A CD1 1 
ATOM   8    C CD2 . PHE A 1 3   ? 134.420 111.173 96.548  1.00 187.88 ?  3   PHE A CD2 1 
ATOM   9    C CE1 . PHE A 1 3   ? 134.700 109.993 94.074  1.00 187.68 ?  3   PHE A CE1 1 
ATOM   10   C CE2 . PHE A 1 3   ? 133.355 111.154 95.670  1.00 187.07 ?  3   PHE A CE2 1 
ATOM   11   C CZ  . PHE A 1 3   ? 133.494 110.563 94.431  1.00 187.69 ?  3   PHE A CZ  1 
ATOM   12   N N   . ASN A 1 4   ? 136.612 113.518 97.996  1.00 187.86 ?  4   ASN A N   1 
ATOM   13   C CA  . ASN A 1 4   ? 135.939 114.797 98.050  1.00 187.77 ?  4   ASN A CA  1 
ATOM   14   C C   . ASN A 1 4   ? 136.744 115.742 97.196  1.00 188.06 ?  4   ASN A C   1 
ATOM   15   O O   . ASN A 1 4   ? 136.193 116.594 96.503  1.00 188.90 ?  4   ASN A O   1 
ATOM   16   C CB  . ASN A 1 4   ? 135.843 115.314 99.481  1.00 187.89 ?  4   ASN A CB  1 
ATOM   17   C CG  . ASN A 1 4   ? 134.917 116.508 99.608  1.00 189.47 ?  4   ASN A CG  1 
ATOM   18   O OD1 . ASN A 1 4   ? 134.358 116.983 98.621  1.00 190.72 ?  4   ASN A OD1 1 
ATOM   19   N ND2 . ASN A 1 4   ? 134.747 116.995 100.830 1.00 189.72 ?  4   ASN A ND2 1 
ATOM   20   N N   . ASP A 1 5   ? 138.055 115.568 97.180  1.00 189.49 ?  5   ASP A N   1 
ATOM   21   C CA  . ASP A 1 5   ? 138.879 116.399 96.320  1.00 191.36 ?  5   ASP A CA  1 
ATOM   22   C C   . ASP A 1 5   ? 138.347 116.373 94.903  1.00 191.48 ?  5   ASP A C   1 
ATOM   23   O O   . ASP A 1 5   ? 137.948 117.404 94.366  1.00 189.74 ?  5   ASP A O   1 
ATOM   24   C CB  . ASP A 1 5   ? 140.325 115.914 96.334  1.00 193.62 ?  5   ASP A CB  1 
ATOM   25   C CG  . ASP A 1 5   ? 141.243 116.796 95.511  1.00 194.59 ?  5   ASP A CG  1 
ATOM   26   O OD1 . ASP A 1 5   ? 142.397 116.386 95.265  1.00 190.98 ?  5   ASP A OD1 1 
ATOM   27   O OD2 . ASP A 1 5   ? 140.814 117.898 95.110  1.00 196.27 -1 5   ASP A OD2 1 
ATOM   28   N N   . LEU A 1 6   ? 138.326 115.193 94.297  1.00 194.12 ?  6   LEU A N   1 
ATOM   29   C CA  . LEU A 1 6   ? 137.884 115.072 92.910  1.00 195.15 ?  6   LEU A CA  1 
ATOM   30   C C   . LEU A 1 6   ? 136.472 115.600 92.675  1.00 196.21 ?  6   LEU A C   1 
ATOM   31   O O   . LEU A 1 6   ? 136.249 116.399 91.771  1.00 197.46 ?  6   LEU A O   1 
ATOM   32   C CB  . LEU A 1 6   ? 137.964 113.611 92.464  1.00 193.75 ?  6   LEU A CB  1 
ATOM   33   C CG  . LEU A 1 6   ? 139.324 112.938 92.635  1.00 196.27 ?  6   LEU A CG  1 
ATOM   34   C CD1 . LEU A 1 6   ? 139.257 111.479 92.211  1.00 195.07 ?  6   LEU A CD1 1 
ATOM   35   C CD2 . LEU A 1 6   ? 140.385 113.685 91.843  1.00 195.84 ?  6   LEU A CD2 1 
ATOM   36   N N   . LEU A 1 7   ? 135.513 115.154 93.476  1.00 181.00 ?  7   LEU A N   1 
ATOM   37   C CA  . LEU A 1 7   ? 134.135 115.566 93.258  1.00 178.48 ?  7   LEU A CA  1 
ATOM   38   C C   . LEU A 1 7   ? 134.100 117.067 93.245  1.00 179.60 ?  7   LEU A C   1 
ATOM   39   O O   . LEU A 1 7   ? 133.501 117.675 92.362  1.00 179.48 ?  7   LEU A O   1 
ATOM   40   C CB  . LEU A 1 7   ? 133.228 115.030 94.357  1.00 176.91 ?  7   LEU A CB  1 
ATOM   41   C CG  . LEU A 1 7   ? 131.820 115.615 94.438  1.00 172.98 ?  7   LEU A CG  1 
ATOM   42   C CD1 . LEU A 1 7   ? 131.029 115.291 93.180  1.00 174.04 ?  7   LEU A CD1 1 
ATOM   43   C CD2 . LEU A 1 7   ? 131.113 115.083 95.674  1.00 173.41 ?  7   LEU A CD2 1 
ATOM   44   N N   . GLN A 1 8   ? 134.766 117.679 94.212  1.00 196.23 ?  8   GLN A N   1 
ATOM   45   C CA  . GLN A 1 8   ? 134.836 119.127 94.226  1.00 196.14 ?  8   GLN A CA  1 
ATOM   46   C C   . GLN A 1 8   ? 135.509 119.577 92.952  1.00 197.33 ?  8   GLN A C   1 
ATOM   47   O O   . GLN A 1 8   ? 135.014 120.469 92.265  1.00 198.43 ?  8   GLN A O   1 
ATOM   48   C CB  . GLN A 1 8   ? 135.596 119.623 95.450  1.00 195.94 ?  8   GLN A CB  1 
ATOM   49   C CG  . GLN A 1 8   ? 134.828 119.429 96.747  1.00 195.81 ?  8   GLN A CG  1 
ATOM   50   C CD  . GLN A 1 8   ? 135.632 119.814 97.971  1.00 196.22 ?  8   GLN A CD  1 
ATOM   51   O OE1 . GLN A 1 8   ? 136.818 120.129 97.877  1.00 196.96 ?  8   GLN A OE1 1 
ATOM   52   N NE2 . GLN A 1 8   ? 134.988 119.786 99.132  1.00 194.47 ?  8   GLN A NE2 1 
ATOM   53   N N   . GLN A 1 9   ? 136.632 118.953 92.622  1.00 191.79 ?  9   GLN A N   1 
ATOM   54   C CA  . GLN A 1 9   ? 137.313 119.286 91.383  1.00 190.71 ?  9   GLN A CA  1 
ATOM   55   C C   . GLN A 1 9   ? 136.311 119.301 90.246  1.00 189.57 ?  9   GLN A C   1 
ATOM   56   O O   . GLN A 1 9   ? 136.430 120.093 89.314  1.00 189.14 ?  9   GLN A O   1 
ATOM   57   C CB  . GLN A 1 9   ? 138.427 118.287 91.088  1.00 189.72 ?  9   GLN A CB  1 
ATOM   58   C CG  . GLN A 1 9   ? 139.103 118.515 89.750  1.00 189.72 ?  9   GLN A CG  1 
ATOM   59   C CD  . GLN A 1 9   ? 139.632 119.926 89.615  1.00 191.94 ?  9   GLN A CD  1 
ATOM   60   O OE1 . GLN A 1 9   ? 139.342 120.618 88.642  1.00 192.24 ?  9   GLN A OE1 1 
ATOM   61   N NE2 . GLN A 1 9   ? 140.397 120.369 90.606  1.00 192.23 ?  9   GLN A NE2 1 
ATOM   62   N N   . VAL A 1 10  ? 135.314 118.429 90.325  1.00 187.10 ?  10  VAL A N   1 
ATOM   63   C CA  . VAL A 1 10  ? 134.304 118.378 89.281  1.00 187.89 ?  10  VAL A CA  1 
ATOM   64   C C   . VAL A 1 10  ? 133.092 119.227 89.643  1.00 189.57 ?  10  VAL A C   1 
ATOM   65   O O   . VAL A 1 10  ? 132.027 118.693 89.950  1.00 191.98 ?  10  VAL A O   1 
ATOM   66   C CB  . VAL A 1 10  ? 133.865 116.929 89.014  1.00 188.96 ?  10  VAL A CB  1 
ATOM   67   C CG1 . VAL A 1 10  ? 132.961 116.869 87.795  1.00 190.13 ?  10  VAL A CG1 1 
ATOM   68   C CG2 . VAL A 1 10  ? 135.082 116.042 88.808  1.00 188.45 ?  10  VAL A CG2 1 
ATOM   69   N N   . GLY A 1 11  ? 133.246 120.546 89.625  1.00 187.57 ?  11  GLY A N   1 
ATOM   70   C CA  . GLY A 1 11  ? 132.133 121.433 89.891  1.00 189.71 ?  11  GLY A CA  1 
ATOM   71   C C   . GLY A 1 11  ? 131.693 121.547 91.335  1.00 190.10 ?  11  GLY A C   1 
ATOM   72   O O   . GLY A 1 11  ? 130.948 122.481 91.661  1.00 189.95 ?  11  GLY A O   1 
ATOM   73   N N   . GLY A 1 12  ? 132.126 120.646 92.216  1.00 181.99 ?  12  GLY A N   1 
ATOM   74   C CA  . GLY A 1 12  ? 131.597 120.611 93.565  1.00 182.51 ?  12  GLY A CA  1 
ATOM   75   C C   . GLY A 1 12  ? 130.102 120.373 93.549  1.00 181.24 ?  12  GLY A C   1 
ATOM   76   O O   . GLY A 1 12  ? 129.642 119.280 93.204  1.00 176.57 ?  12  GLY A O   1 
ATOM   77   N N   . VAL A 1 13  ? 129.333 121.390 93.919  1.00 168.77 ?  13  VAL A N   1 
ATOM   78   C CA  . VAL A 1 13  ? 127.889 121.386 93.720  1.00 163.99 ?  13  VAL A CA  1 
ATOM   79   C C   . VAL A 1 13  ? 127.595 122.210 92.471  1.00 167.07 ?  13  VAL A C   1 
ATOM   80   O O   . VAL A 1 13  ? 128.244 123.233 92.223  1.00 169.11 ?  13  VAL A O   1 
ATOM   81   C CB  . VAL A 1 13  ? 127.149 121.927 94.956  1.00 163.14 ?  13  VAL A CB  1 
ATOM   82   C CG1 . VAL A 1 13  ? 127.122 123.450 94.979  1.00 164.73 ?  13  VAL A CG1 1 
ATOM   83   C CG2 . VAL A 1 13  ? 125.739 121.368 95.016  1.00 163.90 ?  13  VAL A CG2 1 
ATOM   84   N N   . GLY A 1 14  ? 126.644 121.750 91.673  1.00 168.86 ?  14  GLY A N   1 
ATOM   85   C CA  . GLY A 1 14  ? 126.325 122.452 90.446  1.00 167.90 ?  14  GLY A CA  1 
ATOM   86   C C   . GLY A 1 14  ? 125.158 121.844 89.708  1.00 166.61 ?  14  GLY A C   1 
ATOM   87   O O   . GLY A 1 14  ? 124.224 121.336 90.323  1.00 165.35 ?  14  GLY A O   1 
ATOM   88   N N   . ARG A 1 15  ? 125.206 121.883 88.385  1.00 167.72 ?  15  ARG A N   1 
ATOM   89   C CA  . ARG A 1 15  ? 124.087 121.387 87.610  1.00 167.90 ?  15  ARG A CA  1 
ATOM   90   C C   . ARG A 1 15  ? 123.768 119.947 87.963  1.00 167.26 ?  15  ARG A C   1 
ATOM   91   O O   . ARG A 1 15  ? 122.699 119.666 88.497  1.00 174.48 ?  15  ARG A O   1 
ATOM   92   C CB  . ARG A 1 15  ? 124.385 121.510 86.120  1.00 169.01 ?  15  ARG A CB  1 
ATOM   93   C CG  . ARG A 1 15  ? 123.227 121.111 85.226  1.00 167.08 ?  15  ARG A CG  1 
ATOM   94   C CD  . ARG A 1 15  ? 123.471 121.569 83.801  1.00 168.70 ?  15  ARG A CD  1 
ATOM   95   N NE  . ARG A 1 15  ? 123.904 122.962 83.764  1.00 173.05 ?  15  ARG A NE  1 
ATOM   96   C CZ  . ARG A 1 15  ? 123.077 124.001 83.786  1.00 171.93 ?  15  ARG A CZ  1 
ATOM   97   N NH1 . ARG A 1 15  ? 121.767 123.806 83.847  1.00 169.67 1  15  ARG A NH1 1 
ATOM   98   N NH2 . ARG A 1 15  ? 123.559 125.235 83.751  1.00 168.81 ?  15  ARG A NH2 1 
ATOM   99   N N   . PHE A 1 16  ? 124.687 119.032 87.694  1.00 153.66 ?  16  PHE A N   1 
ATOM   100  C CA  . PHE A 1 16  ? 124.377 117.633 87.938  1.00 156.83 ?  16  PHE A CA  1 
ATOM   101  C C   . PHE A 1 16  ? 123.965 117.440 89.375  1.00 159.93 ?  16  PHE A C   1 
ATOM   102  O O   . PHE A 1 16  ? 123.268 116.485 89.701  1.00 168.14 ?  16  PHE A O   1 
ATOM   103  C CB  . PHE A 1 16  ? 125.559 116.724 87.639  1.00 157.33 ?  16  PHE A CB  1 
ATOM   104  C CG  . PHE A 1 16  ? 125.492 115.406 88.356  1.00 161.06 ?  16  PHE A CG  1 
ATOM   105  C CD1 . PHE A 1 16  ? 124.717 114.373 87.864  1.00 159.72 ?  16  PHE A CD1 1 
ATOM   106  C CD2 . PHE A 1 16  ? 126.185 115.211 89.540  1.00 162.42 ?  16  PHE A CD2 1 
ATOM   107  C CE1 . PHE A 1 16  ? 124.645 113.165 88.530  1.00 156.58 ?  16  PHE A CE1 1 
ATOM   108  C CE2 . PHE A 1 16  ? 126.120 114.006 90.209  1.00 161.43 ?  16  PHE A CE2 1 
ATOM   109  C CZ  . PHE A 1 16  ? 125.349 112.980 89.704  1.00 158.96 ?  16  PHE A CZ  1 
ATOM   110  N N   . GLN A 1 17  ? 124.392 118.338 90.249  1.00 159.69 ?  17  GLN A N   1 
ATOM   111  C CA  . GLN A 1 17  ? 124.093 118.129 91.659  1.00 163.89 ?  17  GLN A CA  1 
ATOM   112  C C   . GLN A 1 17  ? 122.735 118.707 92.026  1.00 165.44 ?  17  GLN A C   1 
ATOM   113  O O   . GLN A 1 17  ? 121.938 118.039 92.689  1.00 161.86 ?  17  GLN A O   1 
ATOM   114  C CB  . GLN A 1 17  ? 125.191 118.738 92.526  1.00 162.45 ?  17  GLN A CB  1 
ATOM   115  C CG  . GLN A 1 17  ? 126.533 118.061 92.361  1.00 165.90 ?  17  GLN A CG  1 
ATOM   116  C CD  . GLN A 1 17  ? 126.759 116.988 93.402  1.00 167.16 ?  17  GLN A CD  1 
ATOM   117  O OE1 . GLN A 1 17  ? 126.576 117.219 94.595  1.00 169.58 ?  17  GLN A OE1 1 
ATOM   118  N NE2 . GLN A 1 17  ? 127.153 115.801 92.955  1.00 165.94 ?  17  GLN A NE2 1 
ATOM   119  N N   . GLN A 1 18  ? 122.440 119.931 91.587  1.00 158.15 ?  18  GLN A N   1 
ATOM   120  C CA  . GLN A 1 18  ? 121.144 120.526 91.897  1.00 154.43 ?  18  GLN A CA  1 
ATOM   121  C C   . GLN A 1 18  ? 120.007 119.699 91.308  1.00 154.72 ?  18  GLN A C   1 
ATOM   122  O O   . GLN A 1 18  ? 119.021 119.399 91.995  1.00 159.99 ?  18  GLN A O   1 
ATOM   123  C CB  . GLN A 1 18  ? 121.091 121.967 91.387  1.00 155.82 ?  18  GLN A CB  1 
ATOM   124  C CG  . GLN A 1 18  ? 122.072 122.904 92.074  1.00 158.18 ?  18  GLN A CG  1 
ATOM   125  C CD  . GLN A 1 18  ? 122.459 124.086 91.207  1.00 161.86 ?  18  GLN A CD  1 
ATOM   126  O OE1 . GLN A 1 18  ? 121.908 124.284 90.125  1.00 162.94 ?  18  GLN A OE1 1 
ATOM   127  N NE2 . GLN A 1 18  ? 123.411 124.882 91.681  1.00 162.50 ?  18  GLN A NE2 1 
ATOM   128  N N   . ILE A 1 19  ? 120.141 119.300 90.042  1.00 145.00 ?  19  ILE A N   1 
ATOM   129  C CA  . ILE A 1 19  ? 119.081 118.540 89.384  1.00 142.88 ?  19  ILE A CA  1 
ATOM   130  C C   . ILE A 1 19  ? 118.853 117.212 90.095  1.00 147.96 ?  19  ILE A C   1 
ATOM   131  O O   . ILE A 1 19  ? 117.717 116.859 90.433  1.00 152.65 ?  19  ILE A O   1 
ATOM   132  C CB  . ILE A 1 19  ? 119.406 118.334 87.894  1.00 142.27 ?  19  ILE A CB  1 
ATOM   133  C CG1 . ILE A 1 19  ? 119.225 119.641 87.120  1.00 145.12 ?  19  ILE A CG1 1 
ATOM   134  C CG2 . ILE A 1 19  ? 118.539 117.238 87.304  1.00 146.63 ?  19  ILE A CG2 1 
ATOM   135  C CD1 . ILE A 1 19  ? 120.055 119.728 85.857  1.00 147.68 ?  19  ILE A CD1 1 
ATOM   136  N N   . GLN A 1 20  ? 119.930 116.459 90.344  1.00 147.85 ?  20  GLN A N   1 
ATOM   137  C CA  . GLN A 1 20  ? 119.774 115.147 90.961  1.00 145.50 ?  20  GLN A CA  1 
ATOM   138  C C   . GLN A 1 20  ? 119.258 115.261 92.388  1.00 147.05 ?  20  GLN A C   1 
ATOM   139  O O   . GLN A 1 20  ? 118.401 114.477 92.805  1.00 151.92 ?  20  GLN A O   1 
ATOM   140  C CB  . GLN A 1 20  ? 121.092 114.377 90.929  1.00 146.56 ?  20  GLN A CB  1 
ATOM   141  C CG  . GLN A 1 20  ? 120.980 112.977 91.507  1.00 148.40 ?  20  GLN A CG  1 
ATOM   142  C CD  . GLN A 1 20  ? 121.961 112.004 90.888  1.00 154.44 ?  20  GLN A CD  1 
ATOM   143  O OE1 . GLN A 1 20  ? 122.868 111.512 91.557  1.00 154.24 ?  20  GLN A OE1 1 
ATOM   144  N NE2 . GLN A 1 20  ? 121.791 111.730 89.601  1.00 153.09 ?  20  GLN A NE2 1 
ATOM   145  N N   . VAL A 1 21  ? 119.757 116.235 93.154  1.00 139.96 ?  21  VAL A N   1 
ATOM   146  C CA  . VAL A 1 21  ? 119.277 116.415 94.519  1.00 145.36 ?  21  VAL A CA  1 
ATOM   147  C C   . VAL A 1 21  ? 117.785 116.714 94.524  1.00 148.98 ?  21  VAL A C   1 
ATOM   148  O O   . VAL A 1 21  ? 117.016 116.074 95.251  1.00 148.45 ?  21  VAL A O   1 
ATOM   149  C CB  . VAL A 1 21  ? 120.075 117.524 95.227  1.00 143.74 ?  21  VAL A CB  1 
ATOM   150  C CG1 . VAL A 1 21  ? 119.362 117.959 96.494  1.00 143.30 ?  21  VAL A CG1 1 
ATOM   151  C CG2 . VAL A 1 21  ? 121.480 117.051 95.550  1.00 142.99 ?  21  VAL A CG2 1 
ATOM   152  N N   . THR A 1 22  ? 117.345 117.670 93.702  1.00 140.68 ?  22  THR A N   1 
ATOM   153  C CA  . THR A 1 22  ? 115.927 118.011 93.676  1.00 134.39 ?  22  THR A CA  1 
ATOM   154  C C   . THR A 1 22  ? 115.086 116.814 93.252  1.00 133.03 ?  22  THR A C   1 
ATOM   155  O O   . THR A 1 22  ? 114.060 116.507 93.871  1.00 138.93 ?  22  THR A O   1 
ATOM   156  C CB  . THR A 1 22  ? 115.690 119.200 92.741  1.00 135.05 ?  22  THR A CB  1 
ATOM   157  O OG1 . THR A 1 22  ? 116.166 120.401 93.360  1.00 136.03 ?  22  THR A OG1 1 
ATOM   158  C CG2 . THR A 1 22  ? 114.212 119.351 92.425  1.00 140.29 ?  22  THR A CG2 1 
ATOM   159  N N   . LEU A 1 23  ? 115.530 116.096 92.228  1.00 119.04 ?  23  LEU A N   1 
ATOM   160  C CA  . LEU A 1 23  ? 114.743 114.974 91.721  1.00 125.14 ?  23  LEU A CA  1 
ATOM   161  C C   . LEU A 1 23  ? 114.836 113.708 92.574  1.00 128.22 ?  23  LEU A C   1 
ATOM   162  O O   . LEU A 1 23  ? 114.037 112.798 92.407  1.00 131.81 ?  23  LEU A O   1 
ATOM   163  C CB  . LEU A 1 23  ? 115.142 114.656 90.282  1.00 125.56 ?  23  LEU A CB  1 
ATOM   164  C CG  . LEU A 1 23  ? 114.928 115.803 89.298  1.00 127.64 ?  23  LEU A CG  1 
ATOM   165  C CD1 . LEU A 1 23  ? 115.365 115.399 87.900  1.00 127.30 ?  23  LEU A CD1 1 
ATOM   166  C CD2 . LEU A 1 23  ? 113.472 116.239 89.303  1.00 128.47 ?  23  LEU A CD2 1 
ATOM   167  N N   . VAL A 1 24  ? 115.793 113.638 93.490  1.00 129.27 ?  24  VAL A N   1 
ATOM   168  C CA  . VAL A 1 24  ? 115.861 112.476 94.378  1.00 123.83 ?  24  VAL A CA  1 
ATOM   169  C C   . VAL A 1 24  ? 115.137 112.780 95.679  1.00 125.45 ?  24  VAL A C   1 
ATOM   170  O O   . VAL A 1 24  ? 114.664 111.868 96.349  1.00 125.75 ?  24  VAL A O   1 
ATOM   171  C CB  . VAL A 1 24  ? 117.308 112.027 94.642  1.00 128.47 ?  24  VAL A CB  1 
ATOM   172  C CG1 . VAL A 1 24  ? 117.344 110.904 95.662  1.00 124.70 ?  24  VAL A CG1 1 
ATOM   173  C CG2 . VAL A 1 24  ? 117.952 111.565 93.345  1.00 132.57 ?  24  VAL A CG2 1 
ATOM   174  N N   . VAL A 1 25  ? 115.026 114.054 96.036  1.00 126.52 ?  25  VAL A N   1 
ATOM   175  C CA  . VAL A 1 25  ? 114.251 114.416 97.223  1.00 124.35 ?  25  VAL A CA  1 
ATOM   176  C C   . VAL A 1 25  ? 112.770 114.608 96.917  1.00 126.73 ?  25  VAL A C   1 
ATOM   177  O O   . VAL A 1 25  ? 111.939 114.478 97.830  1.00 128.54 ?  25  VAL A O   1 
ATOM   178  C CB  . VAL A 1 25  ? 114.824 115.679 97.900  1.00 125.20 ?  25  VAL A CB  1 
ATOM   179  C CG1 . VAL A 1 25  ? 114.165 115.915 99.238  1.00 128.81 ?  25  VAL A CG1 1 
ATOM   180  C CG2 . VAL A 1 25  ? 116.305 115.525 98.126  1.00 127.44 ?  25  VAL A CG2 1 
ATOM   181  N N   . LEU A 1 26  ? 112.406 114.886 95.665  1.00 120.36 ?  26  LEU A N   1 
ATOM   182  C CA  . LEU A 1 26  ? 110.991 115.024 95.327  1.00 119.91 ?  26  LEU A CA  1 
ATOM   183  C C   . LEU A 1 26  ? 110.141 113.813 95.709  1.00 119.32 ?  26  LEU A C   1 
ATOM   184  O O   . LEU A 1 26  ? 109.028 114.022 96.222  1.00 115.13 ?  26  LEU A O   1 
ATOM   185  C CB  . LEU A 1 26  ? 110.846 115.337 93.833  1.00 116.19 ?  26  LEU A CB  1 
ATOM   186  C CG  . LEU A 1 26  ? 109.615 116.149 93.438  1.00 118.50 ?  26  LEU A CG  1 
ATOM   187  C CD1 . LEU A 1 26  ? 109.762 117.590 93.885  1.00 113.28 ?  26  LEU A CD1 1 
ATOM   188  C CD2 . LEU A 1 26  ? 109.384 116.072 91.943  1.00 123.29 ?  26  LEU A CD2 1 
ATOM   189  N N   . PRO A 1 27  ? 110.561 112.562 95.485  1.00 114.83 ?  27  PRO A N   1 
ATOM   190  C CA  . PRO A 1 27  ? 109.710 111.434 95.900  1.00 109.15 ?  27  PRO A CA  1 
ATOM   191  C C   . PRO A 1 27  ? 109.405 111.397 97.385  1.00 114.41 ?  27  PRO A C   1 
ATOM   192  O O   . PRO A 1 27  ? 108.355 110.871 97.774  1.00 124.14 ?  27  PRO A O   1 
ATOM   193  C CB  . PRO A 1 27  ? 110.522 110.209 95.467  1.00 109.50 ?  27  PRO A CB  1 
ATOM   194  C CG  . PRO A 1 27  ? 111.304 110.682 94.319  1.00 116.57 ?  27  PRO A CG  1 
ATOM   195  C CD  . PRO A 1 27  ? 111.652 112.111 94.602  1.00 120.63 ?  27  PRO A CD  1 
ATOM   196  N N   . LEU A 1 28  ? 110.287 111.926 98.234  1.00 116.96 ?  28  LEU A N   1 
ATOM   197  C CA  . LEU A 1 28  ? 110.041 111.887 99.670  1.00 120.11 ?  28  LEU A CA  1 
ATOM   198  C C   . LEU A 1 28  ? 108.841 112.726 100.086 1.00 121.42 ?  28  LEU A C   1 
ATOM   199  O O   . LEU A 1 28  ? 108.379 112.591 101.224 1.00 125.04 ?  28  LEU A O   1 
ATOM   200  C CB  . LEU A 1 28  ? 111.278 112.353 100.437 1.00 116.36 ?  28  LEU A CB  1 
ATOM   201  C CG  . LEU A 1 28  ? 112.549 111.527 100.259 1.00 116.77 ?  28  LEU A CG  1 
ATOM   202  C CD1 . LEU A 1 28  ? 113.702 112.184 100.994 1.00 119.24 ?  28  LEU A CD1 1 
ATOM   203  C CD2 . LEU A 1 28  ? 112.337 110.109 100.740 1.00 113.68 ?  28  LEU A CD2 1 
ATOM   204  N N   . LEU A 1 29  ? 108.337 113.592 99.205  1.00 115.15 ?  29  LEU A N   1 
ATOM   205  C CA  . LEU A 1 29  ? 107.150 114.369 99.538  1.00 112.39 ?  29  LEU A CA  1 
ATOM   206  C C   . LEU A 1 29  ? 105.953 113.460 99.799  1.00 114.03 ?  29  LEU A C   1 
ATOM   207  O O   . LEU A 1 29  ? 105.073 113.798 100.597 1.00 114.28 ?  29  LEU A O   1 
ATOM   208  C CB  . LEU A 1 29  ? 106.842 115.359 98.416  1.00 111.49 ?  29  LEU A CB  1 
ATOM   209  C CG  . LEU A 1 29  ? 106.198 116.681 98.828  1.00 107.65 ?  29  LEU A CG  1 
ATOM   210  C CD1 . LEU A 1 29  ? 107.132 117.457 99.736  1.00 117.27 ?  29  LEU A CD1 1 
ATOM   211  C CD2 . LEU A 1 29  ? 105.836 117.499 97.606  1.00 107.73 ?  29  LEU A CD2 1 
ATOM   212  N N   . LEU A 1 30  ? 105.906 112.299 99.143  1.00 104.29 ?  30  LEU A N   1 
ATOM   213  C CA  . LEU A 1 30  ? 104.821 111.341 99.317  1.00 102.52 ?  30  LEU A CA  1 
ATOM   214  C C   . LEU A 1 30  ? 105.128 110.284 100.371 1.00 109.33 ?  30  LEU A C   1 
ATOM   215  O O   . LEU A 1 30  ? 104.264 109.451 100.671 1.00 112.41 ?  30  LEU A O   1 
ATOM   216  C CB  . LEU A 1 30  ? 104.500 110.659 97.986  1.00 104.57 ?  30  LEU A CB  1 
ATOM   217  C CG  . LEU A 1 30  ? 103.975 111.570 96.879  1.00 102.61 ?  30  LEU A CG  1 
ATOM   218  C CD1 . LEU A 1 30  ? 104.306 111.000 95.522  1.00 108.14 ?  30  LEU A CD1 1 
ATOM   219  C CD2 . LEU A 1 30  ? 102.487 111.759 97.015  1.00 105.50 ?  30  LEU A CD2 1 
ATOM   220  N N   . MET A 1 31  ? 106.333 110.298 100.918 1.00 125.05 ?  31  MET A N   1 
ATOM   221  C CA  . MET A 1 31  ? 106.682 109.320 101.929 1.00 129.91 ?  31  MET A CA  1 
ATOM   222  C C   . MET A 1 31  ? 105.748 109.472 103.118 1.00 133.91 ?  31  MET A C   1 
ATOM   223  O O   . MET A 1 31  ? 105.077 108.522 103.511 1.00 135.36 ?  31  MET A O   1 
ATOM   224  C CB  . MET A 1 31  ? 108.130 109.471 102.370 1.00 120.80 ?  31  MET A CB  1 
ATOM   225  C CG  . MET A 1 31  ? 108.575 108.421 103.368 1.00 126.86 ?  31  MET A CG  1 
ATOM   226  S SD  . MET A 1 31  ? 108.523 106.782 102.631 1.00 134.87 ?  31  MET A SD  1 
ATOM   227  C CE  . MET A 1 31  ? 109.614 107.024 101.233 1.00 121.89 ?  31  MET A CE  1 
ATOM   228  N N   . ALA A 1 32  ? 105.692 110.667 103.691 1.00 129.18 ?  32  ALA A N   1 
ATOM   229  C CA  . ALA A 1 32  ? 104.841 110.884 104.858 1.00 125.34 ?  32  ALA A CA  1 
ATOM   230  C C   . ALA A 1 32  ? 103.384 110.562 104.544 1.00 122.37 ?  32  ALA A C   1 
ATOM   231  O O   . ALA A 1 32  ? 102.655 110.053 105.403 1.00 122.70 ?  32  ALA A O   1 
ATOM   232  C CB  . ALA A 1 32  ? 104.986 112.322 105.357 1.00 124.23 ?  32  ALA A CB  1 
ATOM   233  N N   . SER A 1 33  ? 102.947 110.839 103.313 1.00 126.50 ?  33  SER A N   1 
ATOM   234  C CA  . SER A 1 33  ? 101.594 110.472 102.906 1.00 132.52 ?  33  SER A CA  1 
ATOM   235  C C   . SER A 1 33  ? 101.386 108.965 102.971 1.00 131.43 ?  33  SER A C   1 
ATOM   236  O O   . SER A 1 33  ? 100.318 108.497 103.381 1.00 133.99 ?  33  SER A O   1 
ATOM   237  C CB  . SER A 1 33  ? 101.316 110.997 101.499 1.00 130.69 ?  33  SER A CB  1 
ATOM   238  O OG  . SER A 1 33  ? 101.440 112.408 101.463 1.00 133.55 ?  33  SER A OG  1 
ATOM   239  N N   . HIS A 1 34  ? 102.391 108.187 102.571 1.00 112.87 ?  34  HIS A N   1 
ATOM   240  C CA  . HIS A 1 34  ? 102.250 106.736 102.657 1.00 110.27 ?  34  HIS A CA  1 
ATOM   241  C C   . HIS A 1 34  ? 102.334 106.219 104.092 1.00 112.62 ?  34  HIS A C   1 
ATOM   242  O O   . HIS A 1 34  ? 101.591 105.301 104.457 1.00 114.99 ?  34  HIS A O   1 
ATOM   243  C CB  . HIS A 1 34  ? 103.294 106.041 101.793 1.00 110.75 ?  34  HIS A CB  1 
ATOM   244  C CG  . HIS A 1 34  ? 102.813 105.713 100.415 1.00 111.31 ?  34  HIS A CG  1 
ATOM   245  N ND1 . HIS A 1 34  ? 102.899 106.597 99.362  1.00 117.80 ?  34  HIS A ND1 1 
ATOM   246  C CD2 . HIS A 1 34  ? 102.217 104.601 99.926  1.00 108.90 ?  34  HIS A CD2 1 
ATOM   247  C CE1 . HIS A 1 34  ? 102.398 106.034 98.277  1.00 114.80 ?  34  HIS A CE1 1 
ATOM   248  N NE2 . HIS A 1 34  ? 101.972 104.825 98.594  1.00 115.60 ?  34  HIS A NE2 1 
ATOM   249  N N   . ASN A 1 35  ? 103.238 106.758 104.914 1.00 109.87 ?  35  ASN A N   1 
ATOM   250  C CA  . ASN A 1 35  ? 103.364 106.244 106.278 1.00 113.74 ?  35  ASN A CA  1 
ATOM   251  C C   . ASN A 1 35  ? 102.087 106.460 107.079 1.00 116.97 ?  35  ASN A C   1 
ATOM   252  O O   . ASN A 1 35  ? 101.657 105.580 107.832 1.00 120.09 ?  35  ASN A O   1 
ATOM   253  C CB  . ASN A 1 35  ? 104.547 106.882 107.000 1.00 115.19 ?  35  ASN A CB  1 
ATOM   254  C CG  . ASN A 1 35  ? 105.870 106.319 106.555 1.00 111.75 ?  35  ASN A CG  1 
ATOM   255  O OD1 . ASN A 1 35  ? 105.928 105.435 105.700 1.00 107.95 ?  35  ASN A OD1 1 
ATOM   256  N ND2 . ASN A 1 35  ? 106.945 106.787 107.177 1.00 118.26 ?  35  ASN A ND2 1 
ATOM   257  N N   . THR A 1 36  ? 101.471 107.631 106.939 1.00 127.99 ?  36  THR A N   1 
ATOM   258  C CA  . THR A 1 36  ? 100.295 107.991 107.719 1.00 127.96 ?  36  THR A CA  1 
ATOM   259  C C   . THR A 1 36  ? 99.019  107.961 106.887 1.00 131.62 ?  36  THR A C   1 
ATOM   260  O O   . THR A 1 36  ? 98.076  108.704 107.175 1.00 133.77 ?  36  THR A O   1 
ATOM   261  C CB  . THR A 1 36  ? 100.493 109.370 108.341 1.00 127.61 ?  36  THR A CB  1 
ATOM   262  O OG1 . THR A 1 36  ? 100.408 110.362 107.317 1.00 126.61 ?  36  THR A OG1 1 
ATOM   263  C CG2 . THR A 1 36  ? 101.867 109.458 108.971 1.00 137.44 ?  36  THR A CG2 1 
ATOM   264  N N   . LEU A 1 37  ? 98.975  107.117 105.854 1.00 121.69 ?  37  LEU A N   1 
ATOM   265  C CA  . LEU A 1 37  ? 97.811  107.074 104.977 1.00 116.37 ?  37  LEU A CA  1 
ATOM   266  C C   . LEU A 1 37  ? 96.578  106.547 105.694 1.00 124.23 ?  37  LEU A C   1 
ATOM   267  O O   . LEU A 1 37  ? 95.473  107.050 105.466 1.00 130.27 ?  37  LEU A O   1 
ATOM   268  C CB  . LEU A 1 37  ? 98.108  106.217 103.748 1.00 117.24 ?  37  LEU A CB  1 
ATOM   269  C CG  . LEU A 1 37  ? 97.143  106.376 102.574 1.00 116.09 ?  37  LEU A CG  1 
ATOM   270  C CD1 . LEU A 1 37  ? 96.935  107.845 102.257 1.00 116.37 ?  37  LEU A CD1 1 
ATOM   271  C CD2 . LEU A 1 37  ? 97.647  105.625 101.353 1.00 120.99 ?  37  LEU A CD2 1 
ATOM   272  N N   . GLN A 1 38  ? 96.739  105.554 106.568 1.00 135.53 ?  38  GLN A N   1 
ATOM   273  C CA  . GLN A 1 38  ? 95.590  104.910 107.206 1.00 138.57 ?  38  GLN A CA  1 
ATOM   274  C C   . GLN A 1 38  ? 94.796  105.841 108.101 1.00 137.00 ?  38  GLN A C   1 
ATOM   275  O O   . GLN A 1 38  ? 93.782  105.413 108.662 1.00 134.75 ?  38  GLN A O   1 
ATOM   276  C CB  . GLN A 1 38  ? 96.050  103.692 108.004 1.00 133.75 ?  38  GLN A CB  1 
ATOM   277  C CG  . GLN A 1 38  ? 96.439  102.517 107.136 1.00 131.96 ?  38  GLN A CG  1 
ATOM   278  C CD  . GLN A 1 38  ? 96.219  101.190 107.822 1.00 137.10 ?  38  GLN A CD  1 
ATOM   279  O OE1 . GLN A 1 38  ? 95.691  101.133 108.932 1.00 142.37 ?  38  GLN A OE1 1 
ATOM   280  N NE2 . GLN A 1 38  ? 96.622  100.110 107.165 1.00 132.16 ?  38  GLN A NE2 1 
ATOM   281  N N   . ASN A 1 39  ? 95.203  107.097 108.271 1.00 130.53 ?  39  ASN A N   1 
ATOM   282  C CA  . ASN A 1 39  ? 94.371  108.050 108.989 1.00 126.38 ?  39  ASN A CA  1 
ATOM   283  C C   . ASN A 1 39  ? 93.195  108.514 108.144 1.00 131.42 ?  39  ASN A C   1 
ATOM   284  O O   . ASN A 1 39  ? 92.150  108.881 108.692 1.00 137.23 ?  39  ASN A O   1 
ATOM   285  C CB  . ASN A 1 39  ? 95.210  109.248 109.419 1.00 131.19 ?  39  ASN A CB  1 
ATOM   286  C CG  . ASN A 1 39  ? 96.243  108.882 110.449 1.00 131.29 ?  39  ASN A CG  1 
ATOM   287  O OD1 . ASN A 1 39  ? 96.051  107.949 111.225 1.00 129.08 ?  39  ASN A OD1 1 
ATOM   288  N ND2 . ASN A 1 39  ? 97.354  109.606 110.458 1.00 134.19 ?  39  ASN A ND2 1 
ATOM   289  N N   . PHE A 1 40  ? 93.347  108.503 106.821 1.00 125.00 ?  40  PHE A N   1 
ATOM   290  C CA  . PHE A 1 40  ? 92.328  108.979 105.896 1.00 123.79 ?  40  PHE A CA  1 
ATOM   291  C C   . PHE A 1 40  ? 91.736  107.869 105.041 1.00 125.23 ?  40  PHE A C   1 
ATOM   292  O O   . PHE A 1 40  ? 90.571  107.955 104.645 1.00 121.63 ?  40  PHE A O   1 
ATOM   293  C CB  . PHE A 1 40  ? 92.913  110.064 104.987 1.00 118.11 ?  40  PHE A CB  1 
ATOM   294  C CG  . PHE A 1 40  ? 93.477  111.233 105.734 1.00 117.73 ?  40  PHE A CG  1 
ATOM   295  C CD1 . PHE A 1 40  ? 92.682  112.316 106.052 1.00 121.57 ?  40  PHE A CD1 1 
ATOM   296  C CD2 . PHE A 1 40  ? 94.802  111.245 106.128 1.00 122.55 ?  40  PHE A CD2 1 
ATOM   297  C CE1 . PHE A 1 40  ? 93.198  113.391 106.742 1.00 128.28 ?  40  PHE A CE1 1 
ATOM   298  C CE2 . PHE A 1 40  ? 95.323  112.317 106.819 1.00 128.05 ?  40  PHE A CE2 1 
ATOM   299  C CZ  . PHE A 1 40  ? 94.519  113.391 107.128 1.00 131.28 ?  40  PHE A CZ  1 
ATOM   300  N N   . THR A 1 41  ? 92.516  106.833 104.733 1.00 123.01 ?  41  THR A N   1 
ATOM   301  C CA  . THR A 1 41  ? 91.995  105.709 103.968 1.00 119.75 ?  41  THR A CA  1 
ATOM   302  C C   . THR A 1 41  ? 91.428  104.611 104.856 1.00 125.19 ?  41  THR A C   1 
ATOM   303  O O   . THR A 1 41  ? 90.828  103.665 104.338 1.00 134.06 ?  41  THR A O   1 
ATOM   304  C CB  . THR A 1 41  ? 93.085  105.122 103.068 1.00 112.85 ?  41  THR A CB  1 
ATOM   305  O OG1 . THR A 1 41  ? 92.534  104.068 102.273 1.00 108.53 ?  41  THR A OG1 1 
ATOM   306  C CG2 . THR A 1 41  ? 94.210  104.553 103.899 1.00 115.08 ?  41  THR A CG2 1 
ATOM   307  N N   . ALA A 1 42  ? 91.600  104.712 106.174 1.00 121.28 ?  42  ALA A N   1 
ATOM   308  C CA  . ALA A 1 42  ? 91.122  103.694 107.102 1.00 122.70 ?  42  ALA A CA  1 
ATOM   309  C C   . ALA A 1 42  ? 90.394  104.299 108.296 1.00 116.94 ?  42  ALA A C   1 
ATOM   310  O O   . ALA A 1 42  ? 90.353  103.686 109.366 1.00 119.29 ?  42  ALA A O   1 
ATOM   311  C CB  . ALA A 1 42  ? 92.281  102.819 107.580 1.00 123.10 ?  42  ALA A CB  1 
ATOM   312  N N   . ALA A 1 43  ? 89.824  105.489 108.137 1.00 128.16 ?  43  ALA A N   1 
ATOM   313  C CA  . ALA A 1 43  ? 89.122  106.130 109.239 1.00 138.08 ?  43  ALA A CA  1 
ATOM   314  C C   . ALA A 1 43  ? 87.835  105.382 109.564 1.00 136.10 ?  43  ALA A C   1 
ATOM   315  O O   . ALA A 1 43  ? 87.269  104.678 108.725 1.00 137.15 ?  43  ALA A O   1 
ATOM   316  C CB  . ALA A 1 43  ? 88.814  107.586 108.899 1.00 138.92 ?  43  ALA A CB  1 
ATOM   317  N N   . ILE A 1 44  ? 87.374  105.540 110.801 1.00 137.46 ?  44  ILE A N   1 
ATOM   318  C CA  . ILE A 1 44  ? 86.171  104.859 111.269 1.00 136.58 ?  44  ILE A CA  1 
ATOM   319  C C   . ILE A 1 44  ? 85.020  105.852 111.367 1.00 136.80 ?  44  ILE A C   1 
ATOM   320  O O   . ILE A 1 44  ? 84.954  106.627 112.332 1.00 143.50 ?  44  ILE A O   1 
ATOM   321  C CB  . ILE A 1 44  ? 86.407  104.182 112.628 1.00 141.16 ?  44  ILE A CB  1 
ATOM   322  C CG1 . ILE A 1 44  ? 87.617  103.252 112.566 1.00 138.60 ?  44  ILE A CG1 1 
ATOM   323  C CG2 . ILE A 1 44  ? 85.168  103.422 113.063 1.00 141.53 ?  44  ILE A CG2 1 
ATOM   324  C CD1 . ILE A 1 44  ? 87.713  102.301 113.741 1.00 135.61 ?  44  ILE A CD1 1 
ATOM   325  N N   . PRO A 1 45  ? 84.098  105.868 110.411 1.00 122.56 ?  45  PRO A N   1 
ATOM   326  C CA  . PRO A 1 45  ? 82.893  106.684 110.568 1.00 127.29 ?  45  PRO A CA  1 
ATOM   327  C C   . PRO A 1 45  ? 81.979  106.093 111.628 1.00 120.64 ?  45  PRO A C   1 
ATOM   328  O O   . PRO A 1 45  ? 81.997  104.892 111.903 1.00 115.99 ?  45  PRO A O   1 
ATOM   329  C CB  . PRO A 1 45  ? 82.244  106.634 109.183 1.00 127.54 ?  45  PRO A CB  1 
ATOM   330  C CG  . PRO A 1 45  ? 82.728  105.359 108.597 1.00 126.93 ?  45  PRO A CG  1 
ATOM   331  C CD  . PRO A 1 45  ? 84.115  105.147 109.128 1.00 120.67 ?  45  PRO A CD  1 
ATOM   332  N N   . THR A 1 46  ? 81.176  106.963 112.235 1.00 145.33 ?  46  THR A N   1 
ATOM   333  C CA  . THR A 1 46  ? 80.223  106.503 113.235 1.00 147.51 ?  46  THR A CA  1 
ATOM   334  C C   . THR A 1 46  ? 79.233  105.530 112.605 1.00 148.09 ?  46  THR A C   1 
ATOM   335  O O   . THR A 1 46  ? 78.514  105.869 111.662 1.00 148.64 ?  46  THR A O   1 
ATOM   336  C CB  . THR A 1 46  ? 79.497  107.690 113.878 1.00 153.03 ?  46  THR A CB  1 
ATOM   337  O OG1 . THR A 1 46  ? 78.450  107.211 114.732 1.00 150.43 ?  46  THR A OG1 1 
ATOM   338  C CG2 . THR A 1 46  ? 78.928  108.640 112.830 1.00 152.72 ?  46  THR A CG2 1 
ATOM   339  N N   . HIS A 1 47  ? 79.222  104.305 113.118 1.00 158.73 ?  47  HIS A N   1 
ATOM   340  C CA  . HIS A 1 47  ? 78.450  103.215 112.543 1.00 158.80 ?  47  HIS A CA  1 
ATOM   341  C C   . HIS A 1 47  ? 77.381  102.769 113.526 1.00 159.46 ?  47  HIS A C   1 
ATOM   342  O O   . HIS A 1 47  ? 77.572  102.843 114.743 1.00 161.66 ?  47  HIS A O   1 
ATOM   343  C CB  . HIS A 1 47  ? 79.345  102.026 112.197 1.00 152.80 ?  47  HIS A CB  1 
ATOM   344  C CG  . HIS A 1 47  ? 80.384  101.740 113.233 1.00 153.54 ?  47  HIS A CG  1 
ATOM   345  N ND1 . HIS A 1 47  ? 81.663  102.245 113.167 1.00 155.99 ?  47  HIS A ND1 1 
ATOM   346  C CD2 . HIS A 1 47  ? 80.323  101.019 114.377 1.00 156.19 ?  47  HIS A CD2 1 
ATOM   347  C CE1 . HIS A 1 47  ? 82.351  101.835 114.218 1.00 158.35 ?  47  HIS A CE1 1 
ATOM   348  N NE2 . HIS A 1 47  ? 81.559  101.093 114.970 1.00 159.44 ?  47  HIS A NE2 1 
ATOM   349  N N   . HIS A 1 48  ? 76.255  102.307 112.993 1.00 176.58 ?  48  HIS A N   1 
ATOM   350  C CA  . HIS A 1 48  ? 75.207  101.732 113.819 1.00 173.21 ?  48  HIS A CA  1 
ATOM   351  C C   . HIS A 1 48  ? 74.744  100.431 113.182 1.00 175.76 ?  48  HIS A C   1 
ATOM   352  O O   . HIS A 1 48  ? 74.925  100.201 111.985 1.00 180.16 ?  48  HIS A O   1 
ATOM   353  C CB  . HIS A 1 48  ? 74.046  102.719 114.027 1.00 174.08 ?  48  HIS A CB  1 
ATOM   354  C CG  . HIS A 1 48  ? 73.146  102.876 112.840 1.00 174.50 ?  48  HIS A CG  1 
ATOM   355  N ND1 . HIS A 1 48  ? 72.318  101.871 112.388 1.00 176.06 ?  48  HIS A ND1 1 
ATOM   356  C CD2 . HIS A 1 48  ? 72.941  103.930 112.015 1.00 174.22 ?  48  HIS A CD2 1 
ATOM   357  C CE1 . HIS A 1 48  ? 71.644  102.299 111.336 1.00 175.32 ?  48  HIS A CE1 1 
ATOM   358  N NE2 . HIS A 1 48  ? 72.005  103.544 111.087 1.00 174.62 ?  48  HIS A NE2 1 
ATOM   359  N N   . CYS A 1 49  ? 74.163  99.564  114.003 1.00 190.10 ?  49  CYS A N   1 
ATOM   360  C CA  . CYS A 1 49  ? 73.764  98.254  113.512 1.00 189.67 ?  49  CYS A CA  1 
ATOM   361  C C   . CYS A 1 49  ? 72.573  98.368  112.570 1.00 190.21 ?  49  CYS A C   1 
ATOM   362  O O   . CYS A 1 49  ? 71.610  99.095  112.830 1.00 192.54 ?  49  CYS A O   1 
ATOM   363  C CB  . CYS A 1 49  ? 73.428  97.326  114.676 1.00 192.16 ?  49  CYS A CB  1 
ATOM   364  S SG  . CYS A 1 49  ? 74.880  96.706  115.543 1.00 201.16 ?  49  CYS A SG  1 
ATOM   365  N N   . ARG A 1 50  ? 72.651  97.640  111.465 1.00 193.08 ?  50  ARG A N   1 
ATOM   366  C CA  . ARG A 1 50  ? 71.572  97.633  110.485 1.00 195.81 ?  50  ARG A CA  1 
ATOM   367  C C   . ARG A 1 50  ? 70.397  96.828  111.027 1.00 196.09 ?  50  ARG A C   1 
ATOM   368  O O   . ARG A 1 50  ? 70.567  95.656  111.380 1.00 196.15 ?  50  ARG A O   1 
ATOM   369  C CB  . ARG A 1 50  ? 72.056  97.039  109.165 1.00 196.19 ?  50  ARG A CB  1 
ATOM   370  C CG  . ARG A 1 50  ? 70.952  96.595  108.220 1.00 197.20 ?  50  ARG A CG  1 
ATOM   371  C CD  . ARG A 1 50  ? 70.428  97.758  107.389 1.00 195.58 ?  50  ARG A CD  1 
ATOM   372  N NE  . ARG A 1 50  ? 71.457  98.354  106.545 1.00 198.09 ?  50  ARG A NE  1 
ATOM   373  C CZ  . ARG A 1 50  ? 72.004  97.764  105.490 1.00 197.73 ?  50  ARG A CZ  1 
ATOM   374  N NH1 . ARG A 1 50  ? 71.625  96.559  105.095 1.00 195.62 1  50  ARG A NH1 1 
ATOM   375  N NH2 . ARG A 1 50  ? 72.950  98.403  104.808 1.00 197.31 ?  50  ARG A NH2 1 
ATOM   376  N N   . PRO A 1 51  ? 69.204  97.411  111.111 1.00 205.75 ?  51  PRO A N   1 
ATOM   377  C CA  . PRO A 1 51  ? 68.084  96.679  111.680 1.00 206.13 ?  51  PRO A CA  1 
ATOM   378  C C   . PRO A 1 51  ? 67.600  95.606  110.729 1.00 207.56 ?  51  PRO A C   1 
ATOM   379  O O   . PRO A 1 51  ? 67.838  95.676  109.508 1.00 208.28 ?  51  PRO A O   1 
ATOM   380  C CB  . PRO A 1 51  ? 67.026  97.770  111.901 1.00 206.27 ?  51  PRO A CB  1 
ATOM   381  C CG  . PRO A 1 51  ? 67.491  98.971  111.078 1.00 207.42 ?  51  PRO A CG  1 
ATOM   382  C CD  . PRO A 1 51  ? 68.733  98.571  110.341 1.00 206.47 ?  51  PRO A CD  1 
ATOM   383  N N   . PRO A 1 52  ? 66.968  94.553  111.255 1.00 211.28 ?  52  PRO A N   1 
ATOM   384  C CA  . PRO A 1 52  ? 66.393  93.511  110.403 1.00 211.45 ?  52  PRO A CA  1 
ATOM   385  C C   . PRO A 1 52  ? 65.669  94.072  109.187 1.00 212.46 ?  52  PRO A C   1 
ATOM   386  O O   . PRO A 1 52  ? 64.872  95.007  109.288 1.00 211.19 ?  52  PRO A O   1 
ATOM   387  C CB  . PRO A 1 52  ? 65.412  92.820  111.360 1.00 211.13 ?  52  PRO A CB  1 
ATOM   388  C CG  . PRO A 1 52  ? 65.972  93.227  112.810 1.00 210.53 ?  52  PRO A CG  1 
ATOM   389  C CD  . PRO A 1 52  ? 67.293  93.893  112.521 1.00 208.40 ?  52  PRO A CD  1 
ATOM   390  N N   . ALA A 1 53  ? 65.964  93.483  108.026 1.00 223.45 ?  53  ALA A N   1 
ATOM   391  C CA  . ALA A 1 53  ? 65.325  93.912  106.787 1.00 223.36 ?  53  ALA A CA  1 
ATOM   392  C C   . ALA A 1 53  ? 63.834  93.601  106.797 1.00 224.60 ?  53  ALA A C   1 
ATOM   393  O O   . ALA A 1 53  ? 63.042  94.299  106.153 1.00 225.08 ?  53  ALA A O   1 
ATOM   394  C CB  . ALA A 1 53  ? 66.005  93.248  105.590 1.00 221.21 ?  53  ALA A CB  1 
ATOM   395  N N   . LEU A 1 63  ? 65.320  103.867 113.797 1.00 218.65 ?  63  LEU A N   1 
ATOM   396  C CA  . LEU A 1 63  ? 66.373  103.324 114.651 1.00 219.12 ?  63  LEU A CA  1 
ATOM   397  C C   . LEU A 1 63  ? 66.019  103.417 116.128 1.00 219.63 ?  63  LEU A C   1 
ATOM   398  O O   . LEU A 1 63  ? 66.541  102.643 116.940 1.00 218.20 ?  63  LEU A O   1 
ATOM   399  C CB  . LEU A 1 63  ? 67.688  104.054 114.380 1.00 219.16 ?  63  LEU A CB  1 
ATOM   400  C CG  . LEU A 1 63  ? 68.118  104.163 112.916 1.00 218.56 ?  63  LEU A CG  1 
ATOM   401  C CD1 . LEU A 1 63  ? 69.470  104.848 112.810 1.00 218.78 ?  63  LEU A CD1 1 
ATOM   402  C CD2 . LEU A 1 63  ? 68.154  102.792 112.260 1.00 217.03 ?  63  LEU A CD2 1 
ATOM   403  N N   . GLU A 1 64  ? 65.124  104.341 116.490 1.00 226.25 ?  64  GLU A N   1 
ATOM   404  C CA  . GLU A 1 64  ? 64.754  104.531 117.888 1.00 225.70 ?  64  GLU A CA  1 
ATOM   405  C C   . GLU A 1 64  ? 64.261  103.234 118.522 1.00 225.68 ?  64  GLU A C   1 
ATOM   406  O O   . GLU A 1 64  ? 64.425  103.021 119.728 1.00 226.42 ?  64  GLU A O   1 
ATOM   407  C CB  . GLU A 1 64  ? 63.689  105.623 118.000 1.00 223.59 ?  64  GLU A CB  1 
ATOM   408  N N   . VAL A 1 65  ? 63.653  102.349 117.727 1.00 222.60 ?  65  VAL A N   1 
ATOM   409  C CA  . VAL A 1 65  ? 63.210  101.086 118.314 1.00 221.51 ?  65  VAL A CA  1 
ATOM   410  C C   . VAL A 1 65  ? 64.308  100.034 118.215 1.00 219.30 ?  65  VAL A C   1 
ATOM   411  O O   . VAL A 1 65  ? 64.442  99.180  119.100 1.00 218.15 ?  65  VAL A O   1 
ATOM   412  C CB  . VAL A 1 65  ? 61.901  100.598 117.659 1.00 222.06 ?  65  VAL A CB  1 
ATOM   413  C CG1 . VAL A 1 65  ? 62.013  100.604 116.155 1.00 221.55 ?  65  VAL A CG1 1 
ATOM   414  C CG2 . VAL A 1 65  ? 61.520  99.210  118.156 1.00 221.36 ?  65  VAL A CG2 1 
ATOM   415  N N   . TRP A 1 66  ? 65.127  100.088 117.167 1.00 221.00 ?  66  TRP A N   1 
ATOM   416  C CA  . TRP A 1 66  ? 65.994  98.977  116.805 1.00 221.72 ?  66  TRP A CA  1 
ATOM   417  C C   . TRP A 1 66  ? 67.437  99.158  117.259 1.00 221.74 ?  66  TRP A C   1 
ATOM   418  O O   . TRP A 1 66  ? 68.292  98.347  116.893 1.00 222.07 ?  66  TRP A O   1 
ATOM   419  C CB  . TRP A 1 66  ? 65.950  98.760  115.291 1.00 221.76 ?  66  TRP A CB  1 
ATOM   420  N N   . LEU A 1 67  ? 67.733  100.192 118.043 1.00 216.83 ?  67  LEU A N   1 
ATOM   421  C CA  . LEU A 1 67  ? 69.106  100.483 118.445 1.00 218.01 ?  67  LEU A CA  1 
ATOM   422  C C   . LEU A 1 67  ? 69.145  100.852 119.921 1.00 219.06 ?  67  LEU A C   1 
ATOM   423  O O   . LEU A 1 67  ? 68.563  101.884 120.315 1.00 219.36 ?  67  LEU A O   1 
ATOM   424  C CB  . LEU A 1 67  ? 69.692  101.607 117.589 1.00 219.22 ?  67  LEU A CB  1 
ATOM   425  N N   . PRO A 1 68  ? 69.799  100.059 120.768 1.00 223.11 ?  68  PRO A N   1 
ATOM   426  C CA  . PRO A 1 68  ? 69.987  100.470 122.164 1.00 223.03 ?  68  PRO A CA  1 
ATOM   427  C C   . PRO A 1 68  ? 70.834  101.729 122.255 1.00 224.14 ?  68  PRO A C   1 
ATOM   428  O O   . PRO A 1 68  ? 71.733  101.956 121.443 1.00 224.79 ?  68  PRO A O   1 
ATOM   429  C CB  . PRO A 1 68  ? 70.698  99.269  122.800 1.00 223.19 ?  68  PRO A CB  1 
ATOM   430  C CG  . PRO A 1 68  ? 71.263  98.495  121.649 1.00 222.64 ?  68  PRO A CG  1 
ATOM   431  C CD  . PRO A 1 68  ? 70.325  98.710  120.508 1.00 221.80 ?  68  PRO A CD  1 
ATOM   432  N N   . ARG A 1 69  ? 70.541  102.549 123.260 1.00 225.76 ?  69  ARG A N   1 
ATOM   433  C CA  . ARG A 1 69  ? 71.209  103.826 123.455 1.00 226.01 ?  69  ARG A CA  1 
ATOM   434  C C   . ARG A 1 69  ? 72.216  103.724 124.592 1.00 226.11 ?  69  ARG A C   1 
ATOM   435  O O   . ARG A 1 69  ? 71.935  103.121 125.632 1.00 226.21 ?  69  ARG A O   1 
ATOM   436  C CB  . ARG A 1 69  ? 70.197  104.936 123.752 1.00 224.88 ?  69  ARG A CB  1 
ATOM   437  N N   . ASP A 1 70  ? 73.387  104.319 124.397 1.00 228.92 ?  70  ASP A N   1 
ATOM   438  C CA  . ASP A 1 70  ? 74.400  104.313 125.442 1.00 228.30 ?  70  ASP A CA  1 
ATOM   439  C C   . ASP A 1 70  ? 74.271  105.548 126.311 1.00 227.81 ?  70  ASP A C   1 
ATOM   440  O O   . ASP A 1 70  ? 73.381  106.372 126.103 1.00 227.63 ?  70  ASP A O   1 
ATOM   441  C CB  . ASP A 1 70  ? 75.797  104.245 124.831 1.00 228.00 ?  70  ASP A CB  1 
ATOM   442  C CG  . ASP A 1 70  ? 76.094  102.896 124.223 1.00 228.82 ?  70  ASP A CG  1 
ATOM   443  O OD1 . ASP A 1 70  ? 75.347  101.941 124.520 1.00 228.12 ?  70  ASP A OD1 1 
ATOM   444  O OD2 . ASP A 1 70  ? 77.073  102.788 123.456 1.00 230.07 -1 70  ASP A OD2 1 
ATOM   445  N N   . ARG A 1 71  ? 75.159  105.680 127.286 1.00 225.31 ?  71  ARG A N   1 
ATOM   446  C CA  . ARG A 1 71  ? 75.109  106.821 128.188 1.00 225.69 ?  71  ARG A CA  1 
ATOM   447  C C   . ARG A 1 71  ? 74.973  108.136 127.440 1.00 225.89 ?  71  ARG A C   1 
ATOM   448  O O   . ARG A 1 71  ? 74.154  108.977 127.807 1.00 225.44 ?  71  ARG A O   1 
ATOM   449  C CB  . ARG A 1 71  ? 76.365  106.854 129.060 1.00 225.85 ?  71  ARG A CB  1 
ATOM   450  N N   . GLN A 1 72  ? 75.766  108.323 126.392 1.00 234.51 ?  72  GLN A N   1 
ATOM   451  C CA  . GLN A 1 72  ? 75.744  109.593 125.679 1.00 234.20 ?  72  GLN A CA  1 
ATOM   452  C C   . GLN A 1 72  ? 74.402  109.855 125.006 1.00 234.76 ?  72  GLN A C   1 
ATOM   453  O O   . GLN A 1 72  ? 74.161  110.975 124.543 1.00 235.04 ?  72  GLN A O   1 
ATOM   454  C CB  . GLN A 1 72  ? 76.864  109.620 124.638 1.00 233.43 ?  72  GLN A CB  1 
ATOM   455  N N   . GLY A 1 73  ? 73.564  108.825 124.915 1.00 230.25 ?  73  GLY A N   1 
ATOM   456  C CA  . GLY A 1 73  ? 72.292  108.961 124.226 1.00 229.81 ?  73  GLY A CA  1 
ATOM   457  C C   . GLY A 1 73  ? 72.400  108.382 122.832 1.00 230.53 ?  73  GLY A C   1 
ATOM   458  O O   . GLY A 1 73  ? 71.395  107.993 122.239 1.00 229.37 ?  73  GLY A O   1 
ATOM   459  N N   . GLN A 1 74  ? 73.619  108.309 122.305 1.00 231.62 ?  74  GLN A N   1 
ATOM   460  C CA  . GLN A 1 74  ? 73.826  107.803 120.950 1.00 231.47 ?  74  GLN A CA  1 
ATOM   461  C C   . GLN A 1 74  ? 73.510  106.321 120.831 1.00 231.10 ?  74  GLN A C   1 
ATOM   462  O O   . GLN A 1 74  ? 73.548  105.593 121.821 1.00 230.70 ?  74  GLN A O   1 
ATOM   463  C CB  . GLN A 1 74  ? 75.268  108.046 120.513 1.00 229.76 ?  74  GLN A CB  1 
ATOM   464  C CG  . GLN A 1 74  ? 76.293  107.274 121.324 1.00 229.56 ?  74  GLN A CG  1 
ATOM   465  C CD  . GLN A 1 74  ? 77.695  107.414 120.769 1.00 231.14 ?  74  GLN A CD  1 
ATOM   466  O OE1 . GLN A 1 74  ? 77.902  108.029 119.723 1.00 231.77 ?  74  GLN A OE1 1 
ATOM   467  N NE2 . GLN A 1 74  ? 78.668  106.840 121.466 1.00 232.10 ?  74  GLN A NE2 1 
ATOM   468  N N   . PRO A 1 75  ? 73.197  105.867 119.611 1.00 221.81 ?  75  PRO A N   1 
ATOM   469  C CA  . PRO A 1 75  ? 72.930  104.443 119.406 1.00 219.91 ?  75  PRO A CA  1 
ATOM   470  C C   . PRO A 1 75  ? 74.202  103.633 119.542 1.00 222.04 ?  75  PRO A C   1 
ATOM   471  O O   . PRO A 1 75  ? 75.196  103.938 118.887 1.00 222.53 ?  75  PRO A O   1 
ATOM   472  C CB  . PRO A 1 75  ? 72.428  104.386 117.964 1.00 219.12 ?  75  PRO A CB  1 
ATOM   473  C CG  . PRO A 1 75  ? 73.022  105.584 117.308 1.00 221.86 ?  75  PRO A CG  1 
ATOM   474  C CD  . PRO A 1 75  ? 73.060  106.644 118.369 1.00 222.86 ?  75  PRO A CD  1 
ATOM   475  N N   . GLU A 1 76  ? 74.173  102.611 120.386 1.00 219.28 ?  76  GLU A N   1 
ATOM   476  C CA  . GLU A 1 76  ? 75.339  101.762 120.575 1.00 218.50 ?  76  GLU A CA  1 
ATOM   477  C C   . GLU A 1 76  ? 75.756  101.193 119.227 1.00 218.96 ?  76  GLU A C   1 
ATOM   478  O O   . GLU A 1 76  ? 74.901  100.897 118.396 1.00 218.21 ?  76  GLU A O   1 
ATOM   479  C CB  . GLU A 1 76  ? 75.016  100.685 121.607 1.00 217.85 ?  76  GLU A CB  1 
ATOM   480  N N   . SER A 1 77  ? 77.055  101.026 118.995 1.00 205.77 ?  77  SER A N   1 
ATOM   481  C CA  . SER A 1 77  ? 77.521  100.607 117.676 1.00 206.27 ?  77  SER A CA  1 
ATOM   482  C C   . SER A 1 77  ? 77.422  99.098  117.467 1.00 206.36 ?  77  SER A C   1 
ATOM   483  O O   . SER A 1 77  ? 77.218  98.643  116.338 1.00 206.63 ?  77  SER A O   1 
ATOM   484  C CB  . SER A 1 77  ? 78.961  101.075 117.472 1.00 204.55 ?  77  SER A CB  1 
ATOM   485  O OG  . SER A 1 77  ? 79.829  100.463 118.408 1.00 203.15 ?  77  SER A OG  1 
ATOM   486  N N   . CYS A 1 78  ? 77.720  98.278  118.460 1.00 211.12 ?  78  CYS A N   1 
ATOM   487  C CA  . CYS A 1 78  ? 77.749  96.832  118.167 1.00 209.10 ?  78  CYS A CA  1 
ATOM   488  C C   . CYS A 1 78  ? 76.736  95.978  118.914 1.00 209.52 ?  78  CYS A C   1 
ATOM   489  O O   . CYS A 1 78  ? 77.104  94.974  119.518 1.00 208.62 ?  78  CYS A O   1 
ATOM   490  C CB  . CYS A 1 78  ? 79.159  96.261  118.401 1.00 211.08 ?  78  CYS A CB  1 
ATOM   491  S SG  . CYS A 1 78  ? 80.490  97.006  117.420 1.00 221.97 ?  78  CYS A SG  1 
ATOM   492  N N   . LEU A 1 79  ? 75.466  96.357  118.862 1.00 218.02 ?  79  LEU A N   1 
ATOM   493  C CA  . LEU A 1 79  ? 74.426  95.551  119.494 1.00 218.24 ?  79  LEU A CA  1 
ATOM   494  C C   . LEU A 1 79  ? 73.057  95.861  118.919 1.00 218.07 ?  79  LEU A C   1 
ATOM   495  O O   . LEU A 1 79  ? 72.647  97.018  118.874 1.00 219.65 ?  79  LEU A O   1 
ATOM   496  C CB  . LEU A 1 79  ? 74.410  95.773  121.007 1.00 218.22 ?  79  LEU A CB  1 
ATOM   497  C CG  . LEU A 1 79  ? 75.162  94.736  121.840 1.00 217.90 ?  79  LEU A CG  1 
ATOM   498  C CD1 . LEU A 1 79  ? 74.914  94.969  123.322 1.00 218.55 ?  79  LEU A CD1 1 
ATOM   499  C CD2 . LEU A 1 79  ? 74.731  93.334  121.435 1.00 217.44 ?  79  LEU A CD2 1 
ATOM   500  N N   . ARG A 1 80  ? 72.344  94.832  118.481 1.00 213.26 ?  80  ARG A N   1 
ATOM   501  C CA  . ARG A 1 80  ? 70.996  95.045  117.982 1.00 212.97 ?  80  ARG A CA  1 
ATOM   502  C C   . ARG A 1 80  ? 70.026  94.242  118.824 1.00 216.08 ?  80  ARG A C   1 
ATOM   503  O O   . ARG A 1 80  ? 70.293  93.090  119.164 1.00 218.44 ?  80  ARG A O   1 
ATOM   504  C CB  . ARG A 1 80  ? 70.879  94.659  116.509 1.00 214.34 ?  80  ARG A CB  1 
ATOM   505  C CG  . ARG A 1 80  ? 70.794  93.167  116.243 1.00 214.99 ?  80  ARG A CG  1 
ATOM   506  C CD  . ARG A 1 80  ? 70.351  92.906  114.814 1.00 216.60 ?  80  ARG A CD  1 
ATOM   507  N NE  . ARG A 1 80  ? 69.946  91.519  114.612 1.00 215.80 ?  80  ARG A NE  1 
ATOM   508  C CZ  . ARG A 1 80  ? 70.765  90.554  114.212 1.00 215.66 ?  80  ARG A CZ  1 
ATOM   509  N NH1 . ARG A 1 80  ? 72.037  90.823  113.967 1.00 214.50 1  80  ARG A NH1 1 
ATOM   510  N NH2 . ARG A 1 80  ? 70.310  89.319  114.054 1.00 215.97 ?  80  ARG A NH2 1 
ATOM   511  N N   . PHE A 1 81  ? 68.904  94.853  119.178 1.00 228.36 ?  81  PHE A N   1 
ATOM   512  C CA  . PHE A 1 81  ? 67.922  94.168  119.999 1.00 228.41 ?  81  PHE A CA  1 
ATOM   513  C C   . PHE A 1 81  ? 67.510  92.866  119.355 1.00 228.29 ?  81  PHE A C   1 
ATOM   514  O O   . PHE A 1 81  ? 67.259  92.819  118.152 1.00 228.49 ?  81  PHE A O   1 
ATOM   515  C CB  . PHE A 1 81  ? 66.675  95.026  120.183 1.00 227.45 ?  81  PHE A CB  1 
ATOM   516  C CG  . PHE A 1 81  ? 66.911  96.293  120.944 1.00 228.33 ?  81  PHE A CG  1 
ATOM   517  C CD1 . PHE A 1 81  ? 67.269  96.256  122.278 1.00 227.23 ?  81  PHE A CD1 1 
ATOM   518  C CD2 . PHE A 1 81  ? 66.748  97.521  120.329 1.00 228.86 ?  81  PHE A CD2 1 
ATOM   519  C CE1 . PHE A 1 81  ? 67.477  97.423  122.984 1.00 227.37 ?  81  PHE A CE1 1 
ATOM   520  C CE2 . PHE A 1 81  ? 66.951  98.692  121.029 1.00 228.55 ?  81  PHE A CE2 1 
ATOM   521  C CZ  . PHE A 1 81  ? 67.315  98.642  122.359 1.00 227.84 ?  81  PHE A CZ  1 
ATOM   522  N N   . THR A 1 82  ? 67.428  91.804  120.145 1.00 222.04 ?  82  THR A N   1 
ATOM   523  C CA  . THR A 1 82  ? 66.945  90.548  119.605 1.00 221.51 ?  82  THR A CA  1 
ATOM   524  C C   . THR A 1 82  ? 65.538  90.798  119.107 1.00 220.93 ?  82  THR A C   1 
ATOM   525  O O   . THR A 1 82  ? 65.142  90.283  118.062 1.00 219.11 ?  82  THR A O   1 
ATOM   526  C CB  . THR A 1 82  ? 66.939  89.440  120.664 1.00 220.77 ?  82  THR A CB  1 
ATOM   527  O OG1 . THR A 1 82  ? 68.257  89.290  121.206 1.00 219.95 ?  82  THR A OG1 1 
ATOM   528  C CG2 . THR A 1 82  ? 66.495  88.122  120.052 1.00 221.32 ?  82  THR A CG2 1 
ATOM   529  N N   . SER A 1 83  ? 64.779  91.599  119.849 1.00 226.58 ?  83  SER A N   1 
ATOM   530  C CA  . SER A 1 83  ? 63.423  91.938  119.439 1.00 226.33 ?  83  SER A CA  1 
ATOM   531  C C   . SER A 1 83  ? 63.199  93.428  119.612 1.00 227.28 ?  83  SER A C   1 
ATOM   532  O O   . SER A 1 83  ? 63.727  94.030  120.542 1.00 227.38 ?  83  SER A O   1 
ATOM   533  C CB  . SER A 1 83  ? 62.405  91.159  120.263 1.00 226.76 ?  83  SER A CB  1 
ATOM   534  O OG  . SER A 1 83  ? 62.496  91.505  121.633 1.00 226.63 ?  83  SER A OG  1 
ATOM   535  N N   . PRO A 1 84  ? 62.409  94.034  118.718 1.00 234.85 ?  84  PRO A N   1 
ATOM   536  C CA  . PRO A 1 84  ? 62.176  95.481  118.784 1.00 235.00 ?  84  PRO A CA  1 
ATOM   537  C C   . PRO A 1 84  ? 61.541  95.898  120.105 1.00 235.19 ?  84  PRO A C   1 
ATOM   538  O O   . PRO A 1 84  ? 60.783  95.114  120.675 1.00 234.52 ?  84  PRO A O   1 
ATOM   539  C CB  . PRO A 1 84  ? 61.202  95.733  117.627 1.00 233.88 ?  84  PRO A CB  1 
ATOM   540  C CG  . PRO A 1 84  ? 60.572  94.408  117.351 1.00 233.69 ?  84  PRO A CG  1 
ATOM   541  C CD  . PRO A 1 84  ? 61.639  93.395  117.639 1.00 234.21 ?  84  PRO A CD  1 
ATOM   542  N N   . THR A 1 102 ? 69.534  91.237  123.420 1.00 221.73 ?  102 THR A N   1 
ATOM   543  C CA  . THR A 1 102 ? 70.320  91.766  122.314 1.00 221.80 ?  102 THR A CA  1 
ATOM   544  C C   . THR A 1 102 ? 71.015  90.651  121.555 1.00 220.81 ?  102 THR A C   1 
ATOM   545  O O   . THR A 1 102 ? 70.992  89.498  121.982 1.00 220.64 ?  102 THR A O   1 
ATOM   546  C CB  . THR A 1 102 ? 71.381  92.765  122.802 1.00 221.38 ?  102 THR A CB  1 
ATOM   547  O OG1 . THR A 1 102 ? 72.269  92.112  123.717 1.00 220.40 ?  102 THR A OG1 1 
ATOM   548  C CG2 . THR A 1 102 ? 70.720  93.945  123.497 1.00 220.92 ?  102 THR A CG2 1 
ATOM   549  N N   . GLU A 1 103 ? 71.637  90.990  120.432 1.00 220.91 ?  103 GLU A N   1 
ATOM   550  C CA  . GLU A 1 103 ? 72.302  89.981  119.617 1.00 220.48 ?  103 GLU A CA  1 
ATOM   551  C C   . GLU A 1 103 ? 73.443  90.581  118.814 1.00 221.15 ?  103 GLU A C   1 
ATOM   552  O O   . GLU A 1 103 ? 73.447  91.779  118.536 1.00 221.08 ?  103 GLU A O   1 
ATOM   553  C CB  . GLU A 1 103 ? 71.299  89.327  118.667 1.00 220.13 ?  103 GLU A CB  1 
ATOM   554  N N   . PRO A 1 104 ? 74.420  89.749  118.432 1.00 225.33 ?  104 PRO A N   1 
ATOM   555  C CA  . PRO A 1 104 ? 75.500  90.257  117.586 1.00 224.48 ?  104 PRO A CA  1 
ATOM   556  C C   . PRO A 1 104 ? 74.933  90.702  116.257 1.00 226.22 ?  104 PRO A C   1 
ATOM   557  O O   . PRO A 1 104 ? 74.125  89.984  115.672 1.00 226.29 ?  104 PRO A O   1 
ATOM   558  C CB  . PRO A 1 104 ? 76.402  89.038  117.397 1.00 222.69 ?  104 PRO A CB  1 
ATOM   559  C CG  . PRO A 1 104 ? 75.523  87.861  117.658 1.00 224.51 ?  104 PRO A CG  1 
ATOM   560  C CD  . PRO A 1 104 ? 74.565  88.313  118.719 1.00 226.11 ?  104 PRO A CD  1 
ATOM   561  N N   . CYS A 1 105 ? 75.346  91.867  115.780 1.00 220.69 ?  105 CYS A N   1 
ATOM   562  C CA  . CYS A 1 105 ? 74.795  92.394  114.542 1.00 219.99 ?  105 CYS A CA  1 
ATOM   563  C C   . CYS A 1 105 ? 75.383  91.656  113.359 1.00 219.26 ?  105 CYS A C   1 
ATOM   564  O O   . CYS A 1 105 ? 76.565  91.804  113.057 1.00 218.21 ?  105 CYS A O   1 
ATOM   565  C CB  . CYS A 1 105 ? 75.063  93.891  114.457 1.00 218.72 ?  105 CYS A CB  1 
ATOM   566  S SG  . CYS A 1 105 ? 74.438  94.764  115.909 1.00 221.36 ?  105 CYS A SG  1 
ATOM   567  N N   . THR A 1 106 ? 74.563  90.856  112.686 1.00 205.36 ?  106 THR A N   1 
ATOM   568  C CA  . THR A 1 106 ? 75.063  90.049  111.579 1.00 204.96 ?  106 THR A CA  1 
ATOM   569  C C   . THR A 1 106 ? 74.526  90.501  110.234 1.00 204.27 ?  106 THR A C   1 
ATOM   570  O O   . THR A 1 106 ? 74.847  89.913  109.203 1.00 205.58 ?  106 THR A O   1 
ATOM   571  C CB  . THR A 1 106 ? 74.689  88.571  111.773 1.00 206.12 ?  106 THR A CB  1 
ATOM   572  O OG1 . THR A 1 106 ? 75.185  87.801  110.671 1.00 206.48 ?  106 THR A OG1 1 
ATOM   573  C CG2 . THR A 1 106 ? 73.179  88.414  111.857 1.00 204.41 ?  106 THR A CG2 1 
ATOM   574  N N   . ASP A 1 107 ? 73.709  91.543  110.236 1.00 189.29 ?  107 ASP A N   1 
ATOM   575  C CA  . ASP A 1 107 ? 73.135  92.025  108.992 1.00 189.10 ?  107 ASP A CA  1 
ATOM   576  C C   . ASP A 1 107 ? 73.967  93.160  108.426 1.00 190.70 ?  107 ASP A C   1 
ATOM   577  O O   . ASP A 1 107 ? 73.515  93.885  107.542 1.00 190.83 ?  107 ASP A O   1 
ATOM   578  C CB  . ASP A 1 107 ? 71.697  92.485  109.212 1.00 190.50 ?  107 ASP A CB  1 
ATOM   579  C CG  . ASP A 1 107 ? 70.810  91.381  109.747 1.00 191.52 ?  107 ASP A CG  1 
ATOM   580  O OD1 . ASP A 1 107 ? 71.315  90.256  109.947 1.00 190.56 ?  107 ASP A OD1 1 
ATOM   581  O OD2 . ASP A 1 107 ? 69.607  91.637  109.965 1.00 191.72 -1 107 ASP A OD2 1 
ATOM   582  N N   . GLY A 1 108 ? 75.182  93.320  108.934 1.00 184.58 ?  108 GLY A N   1 
ATOM   583  C CA  . GLY A 1 108 ? 76.042  94.390  108.466 1.00 183.11 ?  108 GLY A CA  1 
ATOM   584  C C   . GLY A 1 108 ? 75.759  95.676  109.208 1.00 182.73 ?  108 GLY A C   1 
ATOM   585  O O   . GLY A 1 108 ? 74.863  95.729  110.048 1.00 184.27 ?  108 GLY A O   1 
ATOM   586  N N   . TRP A 1 109 ? 76.516  96.719  108.905 1.00 173.73 ?  109 TRP A N   1 
ATOM   587  C CA  . TRP A 1 109 ? 76.338  97.979  109.605 1.00 176.34 ?  109 TRP A CA  1 
ATOM   588  C C   . TRP A 1 109 ? 76.178  99.134  108.631 1.00 177.27 ?  109 TRP A C   1 
ATOM   589  O O   . TRP A 1 109 ? 76.843  99.177  107.601 1.00 179.29 ?  109 TRP A O   1 
ATOM   590  C CB  . TRP A 1 109 ? 77.522  98.234  110.532 1.00 179.22 ?  109 TRP A CB  1 
ATOM   591  C CG  . TRP A 1 109 ? 77.767  97.136  111.504 1.00 179.48 ?  109 TRP A CG  1 
ATOM   592  C CD1 . TRP A 1 109 ? 77.092  96.904  112.665 1.00 180.59 ?  109 TRP A CD1 1 
ATOM   593  C CD2 . TRP A 1 109 ? 78.765  96.117  111.409 1.00 177.99 ?  109 TRP A CD2 1 
ATOM   594  N NE1 . TRP A 1 109 ? 77.607  95.800  113.298 1.00 178.81 ?  109 TRP A NE1 1 
ATOM   595  C CE2 . TRP A 1 109 ? 78.636  95.298  112.546 1.00 178.30 ?  109 TRP A CE2 1 
ATOM   596  C CE3 . TRP A 1 109 ? 79.755  95.816  110.471 1.00 177.99 ?  109 TRP A CE3 1 
ATOM   597  C CZ2 . TRP A 1 109 ? 79.458  94.200  112.771 1.00 178.20 ?  109 TRP A CZ2 1 
ATOM   598  C CZ3 . TRP A 1 109 ? 80.570  94.727  110.695 1.00 179.70 ?  109 TRP A CZ3 1 
ATOM   599  C CH2 . TRP A 1 109 ? 80.417  93.931  111.836 1.00 178.98 ?  109 TRP A CH2 1 
ATOM   600  N N   . ILE A 1 110 ? 75.298  100.072 108.953 1.00 164.40 ?  110 ILE A N   1 
ATOM   601  C CA  . ILE A 1 110 ? 75.084  101.216 108.087 1.00 161.48 ?  110 ILE A CA  1 
ATOM   602  C C   . ILE A 1 110 ? 76.083  102.302 108.421 1.00 157.76 ?  110 ILE A C   1 
ATOM   603  O O   . ILE A 1 110 ? 75.765  103.249 109.135 1.00 162.24 ?  110 ILE A O   1 
ATOM   604  C CB  . ILE A 1 110 ? 73.667  101.779 108.245 1.00 163.82 ?  110 ILE A CB  1 
ATOM   605  C CG1 . ILE A 1 110 ? 72.646  100.643 108.262 1.00 164.01 ?  110 ILE A CG1 1 
ATOM   606  C CG2 . ILE A 1 110 ? 73.360  102.765 107.128 1.00 164.00 ?  110 ILE A CG2 1 
ATOM   607  C CD1 . ILE A 1 110 ? 71.212  101.116 108.320 1.00 162.86 ?  110 ILE A CD1 1 
ATOM   608  N N   . TYR A 1 111 ? 77.296  102.168 107.910 1.00 141.03 ?  111 TYR A N   1 
ATOM   609  C CA  . TYR A 1 111 ? 78.321  103.156 108.179 1.00 146.51 ?  111 TYR A CA  1 
ATOM   610  C C   . TYR A 1 111 ? 77.848  104.530 107.741 1.00 150.92 ?  111 TYR A C   1 
ATOM   611  O O   . TYR A 1 111 ? 77.233  104.668 106.690 1.00 155.88 ?  111 TYR A O   1 
ATOM   612  C CB  . TYR A 1 111 ? 79.602  102.779 107.447 1.00 147.28 ?  111 TYR A CB  1 
ATOM   613  C CG  . TYR A 1 111 ? 80.028  101.358 107.699 1.00 142.87 ?  111 TYR A CG  1 
ATOM   614  C CD1 . TYR A 1 111 ? 79.684  100.347 106.818 1.00 141.11 ?  111 TYR A CD1 1 
ATOM   615  C CD2 . TYR A 1 111 ? 80.761  101.025 108.826 1.00 148.71 ?  111 TYR A CD2 1 
ATOM   616  C CE1 . TYR A 1 111 ? 80.066  99.042  107.047 1.00 146.83 ?  111 TYR A CE1 1 
ATOM   617  C CE2 . TYR A 1 111 ? 81.148  99.723  109.063 1.00 145.19 ?  111 TYR A CE2 1 
ATOM   618  C CZ  . TYR A 1 111 ? 80.796  98.737  108.170 1.00 145.57 ?  111 TYR A CZ  1 
ATOM   619  O OH  . TYR A 1 111 ? 81.176  97.439  108.400 1.00 145.40 ?  111 TYR A OH  1 
ATOM   620  N N   . ASP A 1 112 ? 78.126  105.549 108.544 1.00 163.32 ?  112 ASP A N   1 
ATOM   621  C CA  . ASP A 1 112 ? 77.729  106.907 108.196 1.00 161.62 ?  112 ASP A CA  1 
ATOM   622  C C   . ASP A 1 112 ? 78.440  107.366 106.937 1.00 161.78 ?  112 ASP A C   1 
ATOM   623  O O   . ASP A 1 112 ? 79.594  107.010 106.712 1.00 162.84 ?  112 ASP A O   1 
ATOM   624  C CB  . ASP A 1 112 ? 78.044  107.861 109.342 1.00 164.00 ?  112 ASP A CB  1 
ATOM   625  C CG  . ASP A 1 112 ? 77.539  109.266 109.092 1.00 166.69 ?  112 ASP A CG  1 
ATOM   626  O OD1 . ASP A 1 112 ? 76.821  109.480 108.093 1.00 168.67 ?  112 ASP A OD1 1 
ATOM   627  O OD2 . ASP A 1 112 ? 77.855  110.160 109.903 1.00 167.35 -1 112 ASP A OD2 1 
ATOM   628  N N   . ASN A 1 113 ? 77.759  108.152 106.113 1.00 160.63 ?  113 ASN A N   1 
ATOM   629  C CA  . ASN A 1 113 ? 78.358  108.647 104.880 1.00 162.54 ?  113 ASN A CA  1 
ATOM   630  C C   . ASN A 1 113 ? 78.666  110.124 104.984 1.00 165.09 ?  113 ASN A C   1 
ATOM   631  O O   . ASN A 1 113 ? 79.122  110.734 104.020 1.00 166.54 ?  113 ASN A O   1 
ATOM   632  C CB  . ASN A 1 113 ? 77.415  108.413 103.702 1.00 160.98 ?  113 ASN A CB  1 
ATOM   633  C CG  . ASN A 1 113 ? 77.000  106.964 103.567 1.00 163.76 ?  113 ASN A CG  1 
ATOM   634  O OD1 . ASN A 1 113 ? 77.544  106.086 104.236 1.00 167.27 ?  113 ASN A OD1 1 
ATOM   635  N ND2 . ASN A 1 113 ? 76.033  106.705 102.696 1.00 163.04 ?  113 ASN A ND2 1 
ATOM   636  N N   . SER A 1 114 ? 78.410  110.710 106.145 1.00 175.70 ?  114 SER A N   1 
ATOM   637  C CA  . SER A 1 114 ? 78.677  112.126 106.328 1.00 175.62 ?  114 SER A CA  1 
ATOM   638  C C   . SER A 1 114 ? 80.061  112.439 105.818 1.00 173.93 ?  114 SER A C   1 
ATOM   639  O O   . SER A 1 114 ? 80.225  113.217 104.882 1.00 174.86 ?  114 SER A O   1 
ATOM   640  C CB  . SER A 1 114 ? 78.571  112.510 107.800 1.00 175.70 ?  114 SER A CB  1 
ATOM   641  O OG  . SER A 1 114 ? 79.521  111.804 108.577 1.00 175.65 ?  114 SER A OG  1 
ATOM   642  N N   . THR A 1 115 ? 81.064  111.828 106.428 1.00 177.47 ?  115 THR A N   1 
ATOM   643  C CA  . THR A 1 115 ? 82.432  112.045 106.004 1.00 181.18 ?  115 THR A CA  1 
ATOM   644  C C   . THR A 1 115 ? 83.047  110.694 105.732 1.00 181.36 ?  115 THR A C   1 
ATOM   645  O O   . THR A 1 115 ? 82.516  109.675 106.166 1.00 182.12 ?  115 THR A O   1 
ATOM   646  C CB  . THR A 1 115 ? 83.238  112.774 107.084 1.00 181.80 ?  115 THR A CB  1 
ATOM   647  O OG1 . THR A 1 115 ? 82.483  113.892 107.568 1.00 181.26 ?  115 THR A OG1 1 
ATOM   648  C CG2 . THR A 1 115 ? 84.564  113.268 106.525 1.00 181.97 ?  115 THR A CG2 1 
ATOM   649  N N   . PHE A 1 116 ? 84.158  110.670 105.012 1.00 159.07 ?  116 PHE A N   1 
ATOM   650  C CA  . PHE A 1 116 ? 84.783  109.409 104.666 1.00 153.82 ?  116 PHE A CA  1 
ATOM   651  C C   . PHE A 1 116 ? 83.769  108.551 103.938 1.00 155.04 ?  116 PHE A C   1 
ATOM   652  O O   . PHE A 1 116 ? 83.213  107.617 104.508 1.00 159.65 ?  116 PHE A O   1 
ATOM   653  C CB  . PHE A 1 116 ? 85.288  108.693 105.912 1.00 150.59 ?  116 PHE A CB  1 
ATOM   654  C CG  . PHE A 1 116 ? 85.992  109.591 106.880 1.00 153.10 ?  116 PHE A CG  1 
ATOM   655  C CD1 . PHE A 1 116 ? 87.258  110.070 106.602 1.00 152.03 ?  116 PHE A CD1 1 
ATOM   656  C CD2 . PHE A 1 116 ? 85.389  109.951 108.070 1.00 158.00 ?  116 PHE A CD2 1 
ATOM   657  C CE1 . PHE A 1 116 ? 87.908  110.898 107.493 1.00 155.84 ?  116 PHE A CE1 1 
ATOM   658  C CE2 . PHE A 1 116 ? 86.033  110.778 108.967 1.00 157.33 ?  116 PHE A CE2 1 
ATOM   659  C CZ  . PHE A 1 116 ? 87.296  111.252 108.678 1.00 155.85 ?  116 PHE A CZ  1 
ATOM   660  N N   . PRO A 1 117 ? 83.526  108.865 102.664 1.00 139.48 ?  117 PRO A N   1 
ATOM   661  C CA  . PRO A 1 117 ? 82.573  108.091 101.873 1.00 141.40 ?  117 PRO A CA  1 
ATOM   662  C C   . PRO A 1 117 ? 82.887  106.614 101.971 1.00 141.47 ?  117 PRO A C   1 
ATOM   663  O O   . PRO A 1 117 ? 81.976  105.808 102.138 1.00 142.17 ?  117 PRO A O   1 
ATOM   664  C CB  . PRO A 1 117 ? 82.814  108.589 100.449 1.00 137.35 ?  117 PRO A CB  1 
ATOM   665  C CG  . PRO A 1 117 ? 84.203  109.124 100.459 1.00 139.20 ?  117 PRO A CG  1 
ATOM   666  C CD  . PRO A 1 117 ? 84.389  109.710 101.826 1.00 140.80 ?  117 PRO A CD  1 
ATOM   667  N N   . SER A 1 118 ? 84.163  106.262 101.876 1.00 136.29 ?  118 SER A N   1 
ATOM   668  C CA  . SER A 1 118 ? 84.557  104.863 101.954 1.00 141.00 ?  118 SER A CA  1 
ATOM   669  C C   . SER A 1 118 ? 85.963  104.690 102.477 1.00 136.17 ?  118 SER A C   1 
ATOM   670  O O   . SER A 1 118 ? 86.896  105.280 101.947 1.00 137.19 ?  118 SER A O   1 
ATOM   671  C CB  . SER A 1 118 ? 84.455  104.210 100.577 1.00 142.25 ?  118 SER A CB  1 
ATOM   672  O OG  . SER A 1 118 ? 84.920  102.874 100.612 1.00 138.14 ?  118 SER A OG  1 
ATOM   673  N N   . THR A 1 119 ? 86.123  103.884 103.513 1.00 121.50 ?  119 THR A N   1 
ATOM   674  C CA  . THR A 1 119 ? 87.444  103.597 104.031 1.00 116.53 ?  119 THR A CA  1 
ATOM   675  C C   . THR A 1 119 ? 87.513  102.099 104.188 1.00 125.62 ?  119 THR A C   1 
ATOM   676  O O   . THR A 1 119 ? 86.480  101.441 104.267 1.00 128.94 ?  119 THR A O   1 
ATOM   677  C CB  . THR A 1 119 ? 87.691  104.274 105.378 1.00 114.99 ?  119 THR A CB  1 
ATOM   678  O OG1 . THR A 1 119 ? 86.639  103.924 106.283 1.00 128.36 ?  119 THR A OG1 1 
ATOM   679  C CG2 . THR A 1 119 ? 87.725  105.781 105.216 1.00 119.43 ?  119 THR A CG2 1 
ATOM   680  N N   . ILE A 1 120 ? 88.711  101.532 104.203 1.00 109.20 ?  120 ILE A N   1 
ATOM   681  C CA  . ILE A 1 120 ? 88.811  100.087 104.268 1.00 105.54 ?  120 ILE A CA  1 
ATOM   682  C C   . ILE A 1 120 ? 87.844  99.594  105.327 1.00 110.14 ?  120 ILE A C   1 
ATOM   683  O O   . ILE A 1 120 ? 87.166  98.593  105.129 1.00 116.77 ?  120 ILE A O   1 
ATOM   684  C CB  . ILE A 1 120 ? 90.240  99.603  104.564 1.00 96.79  ?  120 ILE A CB  1 
ATOM   685  C CG1 . ILE A 1 120 ? 90.751  100.172 105.884 1.00 97.71  ?  120 ILE A CG1 1 
ATOM   686  C CG2 . ILE A 1 120 ? 91.173  99.993  103.429 1.00 105.84 ?  120 ILE A CG2 1 
ATOM   687  C CD1 . ILE A 1 120 ? 92.131  99.674  106.248 1.00 101.37 ?  120 ILE A CD1 1 
ATOM   688  N N   . VAL A 1 121 ? 87.754  100.308 106.440 1.00 113.44 ?  121 VAL A N   1 
ATOM   689  C CA  . VAL A 1 121 ? 86.830  99.925  107.495 1.00 107.73 ?  121 VAL A CA  1 
ATOM   690  C C   . VAL A 1 121 ? 85.448  99.707  106.920 1.00 113.71 ?  121 VAL A C   1 
ATOM   691  O O   . VAL A 1 121 ? 84.844  98.661  107.128 1.00 129.45 ?  121 VAL A O   1 
ATOM   692  C CB  . VAL A 1 121 ? 86.756  100.999 108.585 1.00 109.40 ?  121 VAL A CB  1 
ATOM   693  C CG1 . VAL A 1 121 ? 85.436  100.927 109.329 1.00 104.63 ?  121 VAL A CG1 1 
ATOM   694  C CG2 . VAL A 1 121 ? 87.935  100.878 109.534 1.00 119.82 ?  121 VAL A CG2 1 
ATOM   695  N N   . THR A 1 122 ? 84.947  100.684 106.184 1.00 122.31 ?  122 THR A N   1 
ATOM   696  C CA  . THR A 1 122 ? 83.613  100.586 105.613 1.00 125.82 ?  122 THR A CA  1 
ATOM   697  C C   . THR A 1 122 ? 83.541  99.540  104.517 1.00 128.52 ?  122 THR A C   1 
ATOM   698  O O   . THR A 1 122 ? 82.599  98.757  104.465 1.00 133.00 ?  122 THR A O   1 
ATOM   699  C CB  . THR A 1 122 ? 83.156  101.932 105.035 1.00 129.05 ?  122 THR A CB  1 
ATOM   700  O OG1 . THR A 1 122 ? 83.009  102.880 106.099 1.00 132.15 ?  122 THR A OG1 1 
ATOM   701  C CG2 . THR A 1 122 ? 81.826  101.781 104.321 1.00 129.73 ?  122 THR A CG2 1 
ATOM   702  N N   . GLU A 1 123 ? 84.533  99.513  103.643 1.00 131.75 ?  123 GLU A N   1 
ATOM   703  C CA  . GLU A 1 123 ? 84.500  98.586  102.517 1.00 135.43 ?  123 GLU A CA  1 
ATOM   704  C C   . GLU A 1 123 ? 84.508  97.126  102.938 1.00 134.54 ?  123 GLU A C   1 
ATOM   705  O O   . GLU A 1 123 ? 83.731  96.332  102.418 1.00 136.90 ?  123 GLU A O   1 
ATOM   706  C CB  . GLU A 1 123 ? 85.686  98.856  101.591 1.00 137.50 ?  123 GLU A CB  1 
ATOM   707  C CG  . GLU A 1 123 ? 86.002  97.734  100.617 1.00 138.37 ?  123 GLU A CG  1 
ATOM   708  C CD  . GLU A 1 123 ? 85.018  97.656  99.469  1.00 139.40 ?  123 GLU A CD  1 
ATOM   709  O OE1 . GLU A 1 123 ? 85.056  96.657  98.720  1.00 135.78 ?  123 GLU A OE1 1 
ATOM   710  O OE2 . GLU A 1 123 ? 84.209  98.594  99.313  1.00 143.04 -1 123 GLU A OE2 1 
ATOM   711  N N   . TRP A 1 124 ? 85.375  96.762  103.873 1.00 113.55 ?  124 TRP A N   1 
ATOM   712  C CA  . TRP A 1 124 ? 85.491  95.360  104.263 1.00 114.46 ?  124 TRP A CA  1 
ATOM   713  C C   . TRP A 1 124 ? 84.983  95.104  105.670 1.00 120.38 ?  124 TRP A C   1 
ATOM   714  O O   . TRP A 1 124 ? 85.390  94.139  106.310 1.00 123.95 ?  124 TRP A O   1 
ATOM   715  C CB  . TRP A 1 124 ? 86.936  94.895  104.123 1.00 111.45 ?  124 TRP A CB  1 
ATOM   716  C CG  . TRP A 1 124 ? 87.399  94.867  102.709 1.00 114.24 ?  124 TRP A CG  1 
ATOM   717  C CD1 . TRP A 1 124 ? 86.703  94.408  101.632 1.00 116.41 ?  124 TRP A CD1 1 
ATOM   718  C CD2 . TRP A 1 124 ? 88.667  95.303  102.211 1.00 112.35 ?  124 TRP A CD2 1 
ATOM   719  N NE1 . TRP A 1 124 ? 87.455  94.537  100.492 1.00 122.78 ?  124 TRP A NE1 1 
ATOM   720  C CE2 . TRP A 1 124 ? 88.667  95.083  100.822 1.00 115.91 ?  124 TRP A CE2 1 
ATOM   721  C CE3 . TRP A 1 124 ? 89.801  95.860  102.804 1.00 111.31 ?  124 TRP A CE3 1 
ATOM   722  C CZ2 . TRP A 1 124 ? 89.754  95.401  100.018 1.00 113.43 ?  124 TRP A CZ2 1 
ATOM   723  C CZ3 . TRP A 1 124 ? 90.878  96.173  102.005 1.00 108.95 ?  124 TRP A CZ3 1 
ATOM   724  C CH2 . TRP A 1 124 ? 90.847  95.944  100.627 1.00 111.03 ?  124 TRP A CH2 1 
ATOM   725  N N   . ASP A 1 125 ? 84.108  95.968  106.164 1.00 135.12 ?  125 ASP A N   1 
ATOM   726  C CA  . ASP A 1 125 ? 83.508  95.758  107.481 1.00 135.26 ?  125 ASP A CA  1 
ATOM   727  C C   . ASP A 1 125 ? 84.514  95.420  108.570 1.00 136.74 ?  125 ASP A C   1 
ATOM   728  O O   . ASP A 1 125 ? 84.283  94.515  109.365 1.00 137.85 ?  125 ASP A O   1 
ATOM   729  C CB  . ASP A 1 125 ? 82.445  94.665  107.402 1.00 131.87 ?  125 ASP A CB  1 
ATOM   730  C CG  . ASP A 1 125 ? 81.288  95.046  106.507 1.00 133.97 ?  125 ASP A CG  1 
ATOM   731  O OD1 . ASP A 1 125 ? 81.268  96.195  106.020 1.00 134.09 ?  125 ASP A OD1 1 
ATOM   732  O OD2 . ASP A 1 125 ? 80.396  94.200  106.292 1.00 134.66 -1 125 ASP A OD2 1 
ATOM   733  N N   . LEU A 1 126 ? 85.624  96.144  108.608 1.00 127.27 ?  126 LEU A N   1 
ATOM   734  C CA  . LEU A 1 126 ? 86.616  95.929  109.645 1.00 122.50 ?  126 LEU A CA  1 
ATOM   735  C C   . LEU A 1 126 ? 86.206  96.682  110.891 1.00 128.58 ?  126 LEU A C   1 
ATOM   736  O O   . LEU A 1 126 ? 86.899  97.601  111.317 1.00 128.05 ?  126 LEU A O   1 
ATOM   737  C CB  . LEU A 1 126 ? 87.979  96.421  109.183 1.00 122.35 ?  126 LEU A CB  1 
ATOM   738  C CG  . LEU A 1 126 ? 88.500  95.904  107.847 1.00 126.07 ?  126 LEU A CG  1 
ATOM   739  C CD1 . LEU A 1 126 ? 89.684  96.742  107.395 1.00 131.28 ?  126 LEU A CD1 1 
ATOM   740  C CD2 . LEU A 1 126 ? 88.881  94.437  107.953 1.00 125.73 ?  126 LEU A CD2 1 
ATOM   741  N N   . VAL A 1 127 ? 85.074  96.316  111.476 1.00 151.60 ?  127 VAL A N   1 
ATOM   742  C CA  . VAL A 1 127 ? 84.632  96.974  112.698 1.00 150.13 ?  127 VAL A CA  1 
ATOM   743  C C   . VAL A 1 127 ? 84.156  96.007  113.760 1.00 150.50 ?  127 VAL A C   1 
ATOM   744  O O   . VAL A 1 127 ? 84.331  94.798  113.632 1.00 154.25 ?  127 VAL A O   1 
ATOM   745  C CB  . VAL A 1 127 ? 83.488  97.956  112.426 1.00 153.82 ?  127 VAL A CB  1 
ATOM   746  C CG1 . VAL A 1 127 ? 84.029  99.281  111.920 1.00 156.55 ?  127 VAL A CG1 1 
ATOM   747  C CG2 . VAL A 1 127 ? 82.500  97.353  111.446 1.00 154.28 ?  127 VAL A CG2 1 
ATOM   748  N N   . CYS A 1 128 ? 83.566  96.544  114.818 1.00 164.62 ?  128 CYS A N   1 
ATOM   749  C CA  . CYS A 1 128 ? 83.078  95.702  115.901 1.00 165.65 ?  128 CYS A CA  1 
ATOM   750  C C   . CYS A 1 128 ? 84.102  94.655  116.293 1.00 166.07 ?  128 CYS A C   1 
ATOM   751  O O   . CYS A 1 128 ? 85.202  94.991  116.725 1.00 172.30 ?  128 CYS A O   1 
ATOM   752  C CB  . CYS A 1 128 ? 81.762  95.032  115.518 1.00 169.49 ?  128 CYS A CB  1 
ATOM   753  S SG  . CYS A 1 128 ? 80.322  96.122  115.600 1.00 183.76 ?  128 CYS A SG  1 
ATOM   754  N N   . SER A 1 129 ? 83.754  93.386  116.139 1.00 150.44 ?  129 SER A N   1 
ATOM   755  C CA  . SER A 1 129 ? 84.648  92.317  116.565 1.00 155.90 ?  129 SER A CA  1 
ATOM   756  C C   . SER A 1 129 ? 86.031  92.385  115.929 1.00 156.90 ?  129 SER A C   1 
ATOM   757  O O   . SER A 1 129 ? 87.027  92.131  116.601 1.00 156.06 ?  129 SER A O   1 
ATOM   758  C CB  . SER A 1 129 ? 84.013  90.962  116.258 1.00 155.36 ?  129 SER A CB  1 
ATOM   759  O OG  . SER A 1 129 ? 83.787  90.815  114.868 1.00 152.20 ?  129 SER A OG  1 
ATOM   760  N N   . HIS A 1 130 ? 86.110  92.720  114.647 1.00 149.89 ?  130 HIS A N   1 
ATOM   761  C CA  . HIS A 1 130 ? 87.403  92.717  113.965 1.00 148.58 ?  130 HIS A CA  1 
ATOM   762  C C   . HIS A 1 130 ? 88.084  94.075  113.956 1.00 151.44 ?  130 HIS A C   1 
ATOM   763  O O   . HIS A 1 130 ? 89.107  94.245  113.301 1.00 153.37 ?  130 HIS A O   1 
ATOM   764  C CB  . HIS A 1 130 ? 87.230  92.235  112.528 1.00 142.51 ?  130 HIS A CB  1 
ATOM   765  C CG  . HIS A 1 130 ? 86.703  90.841  112.418 1.00 145.27 ?  130 HIS A CG  1 
ATOM   766  N ND1 . HIS A 1 130 ? 85.360  90.563  112.290 1.00 152.02 ?  130 HIS A ND1 1 
ATOM   767  C CD2 . HIS A 1 130 ? 87.338  89.646  112.414 1.00 147.09 ?  130 HIS A CD2 1 
ATOM   768  C CE1 . HIS A 1 130 ? 85.190  89.255  112.213 1.00 154.23 ?  130 HIS A CE1 1 
ATOM   769  N NE2 . HIS A 1 130 ? 86.374  88.676  112.286 1.00 154.34 ?  130 HIS A NE2 1 
ATOM   770  N N   . ARG A 1 131 ? 87.541  95.038  114.685 1.00 153.90 ?  131 ARG A N   1 
ATOM   771  C CA  . ARG A 1 131 ? 88.089  96.392  114.657 1.00 151.42 ?  131 ARG A CA  1 
ATOM   772  C C   . ARG A 1 131 ? 89.609  96.385  114.754 1.00 149.78 ?  131 ARG A C   1 
ATOM   773  O O   . ARG A 1 131 ? 90.273  97.222  114.128 1.00 148.66 ?  131 ARG A O   1 
ATOM   774  C CB  . ARG A 1 131 ? 87.482  97.237  115.782 1.00 149.68 ?  131 ARG A CB  1 
ATOM   775  C CG  . ARG A 1 131 ? 88.033  96.953  117.174 1.00 148.03 ?  131 ARG A CG  1 
ATOM   776  C CD  . ARG A 1 131 ? 87.251  97.681  118.254 1.00 148.92 ?  131 ARG A CD  1 
ATOM   777  N NE  . ARG A 1 131 ? 86.097  96.915  118.710 1.00 155.47 ?  131 ARG A NE  1 
ATOM   778  C CZ  . ARG A 1 131 ? 85.247  97.327  119.640 1.00 156.21 ?  131 ARG A CZ  1 
ATOM   779  N NH1 . ARG A 1 131 ? 85.388  98.500  120.236 1.00 156.58 1  131 ARG A NH1 1 
ATOM   780  N NH2 . ARG A 1 131 ? 84.229  96.542  119.982 1.00 154.89 ?  131 ARG A NH2 1 
ATOM   781  N N   . ALA A 1 132 ? 90.176  95.430  115.496 1.00 145.31 ?  132 ALA A N   1 
ATOM   782  C CA  . ALA A 1 132 ? 91.622  95.344  115.641 1.00 147.77 ?  132 ALA A CA  1 
ATOM   783  C C   . ALA A 1 132 ? 92.328  95.232  114.300 1.00 146.09 ?  132 ALA A C   1 
ATOM   784  O O   . ALA A 1 132 ? 93.446  95.741  114.160 1.00 146.32 ?  132 ALA A O   1 
ATOM   785  C CB  . ALA A 1 132 ? 91.987  94.153  116.525 1.00 152.22 ?  132 ALA A CB  1 
ATOM   786  N N   . LEU A 1 133 ? 91.688  94.605  113.309 1.00 132.96 ?  133 LEU A N   1 
ATOM   787  C CA  . LEU A 1 133 ? 92.308  94.474  111.997 1.00 135.64 ?  133 LEU A CA  1 
ATOM   788  C C   . LEU A 1 133 ? 92.714  95.825  111.429 1.00 141.83 ?  133 LEU A C   1 
ATOM   789  O O   . LEU A 1 133 ? 93.742  95.922  110.748 1.00 139.81 ?  133 LEU A O   1 
ATOM   790  C CB  . LEU A 1 133 ? 91.361  93.760  111.034 1.00 130.04 ?  133 LEU A CB  1 
ATOM   791  C CG  . LEU A 1 133 ? 91.033  92.306  111.365 1.00 133.46 ?  133 LEU A CG  1 
ATOM   792  C CD1 . LEU A 1 133 ? 90.200  91.686  110.260 1.00 137.48 ?  133 LEU A CD1 1 
ATOM   793  C CD2 . LEU A 1 133 ? 92.306  91.514  111.586 1.00 131.76 ?  133 LEU A CD2 1 
ATOM   794  N N   . ARG A 1 134 ? 91.946  96.881  111.724 1.00 134.87 ?  134 ARG A N   1 
ATOM   795  C CA  . ARG A 1 134 ? 92.296  98.205  111.218 1.00 130.26 ?  134 ARG A CA  1 
ATOM   796  C C   . ARG A 1 134 ? 93.720  98.578  111.598 1.00 137.26 ?  134 ARG A C   1 
ATOM   797  O O   . ARG A 1 134 ? 94.465  99.130  110.780 1.00 134.80 ?  134 ARG A O   1 
ATOM   798  C CB  . ARG A 1 134 ? 91.324  99.256  111.748 1.00 128.10 ?  134 ARG A CB  1 
ATOM   799  C CG  . ARG A 1 134 ? 91.508  100.620 111.107 1.00 128.88 ?  134 ARG A CG  1 
ATOM   800  C CD  . ARG A 1 134 ? 90.723  101.684 111.844 1.00 130.46 ?  134 ARG A CD  1 
ATOM   801  N NE  . ARG A 1 134 ? 91.472  102.266 112.951 1.00 133.53 ?  134 ARG A NE  1 
ATOM   802  C CZ  . ARG A 1 134 ? 92.330  103.270 112.829 1.00 133.28 ?  134 ARG A CZ  1 
ATOM   803  N NH1 . ARG A 1 134 ? 92.577  103.829 111.656 1.00 139.59 1  134 ARG A NH1 1 
ATOM   804  N NH2 . ARG A 1 134 ? 92.952  103.727 113.912 1.00 129.32 ?  134 ARG A NH2 1 
ATOM   805  N N   . GLN A 1 135 ? 94.120  98.282  112.834 1.00 140.93 ?  135 GLN A N   1 
ATOM   806  C CA  . GLN A 1 135 ? 95.504  98.511  113.221 1.00 131.91 ?  135 GLN A CA  1 
ATOM   807  C C   . GLN A 1 135 ? 96.437  97.473  112.618 1.00 130.87 ?  135 GLN A C   1 
ATOM   808  O O   . GLN A 1 135 ? 97.520  97.832  112.140 1.00 136.15 ?  135 GLN A O   1 
ATOM   809  C CB  . GLN A 1 135 ? 95.627  98.531  114.743 1.00 131.60 ?  135 GLN A CB  1 
ATOM   810  C CG  . GLN A 1 135 ? 95.015  99.769  115.373 1.00 132.91 ?  135 GLN A CG  1 
ATOM   811  C CD  . GLN A 1 135 ? 93.863  99.446  116.297 1.00 138.20 ?  135 GLN A CD  1 
ATOM   812  O OE1 . GLN A 1 135 ? 93.928  98.504  117.084 1.00 139.28 ?  135 GLN A OE1 1 
ATOM   813  N NE2 . GLN A 1 135 ? 92.794  100.227 116.203 1.00 136.07 ?  135 GLN A NE2 1 
ATOM   814  N N   . LEU A 1 136 ? 96.013  96.204  112.588 1.00 118.03 ?  136 LEU A N   1 
ATOM   815  C CA  . LEU A 1 136 ? 96.892  95.135  112.120 1.00 121.00 ?  136 LEU A CA  1 
ATOM   816  C C   . LEU A 1 136 ? 97.494  95.474  110.768 1.00 127.30 ?  136 LEU A C   1 
ATOM   817  O O   . LEU A 1 136 ? 98.712  95.364  110.580 1.00 134.02 ?  136 LEU A O   1 
ATOM   818  C CB  . LEU A 1 136 ? 96.128  93.815  112.037 1.00 122.14 ?  136 LEU A CB  1 
ATOM   819  C CG  . LEU A 1 136 ? 96.918  92.645  111.445 1.00 116.58 ?  136 LEU A CG  1 
ATOM   820  C CD1 . LEU A 1 136 ? 97.974  92.164  112.419 1.00 117.41 ?  136 LEU A CD1 1 
ATOM   821  C CD2 . LEU A 1 136 ? 95.995  91.506  111.050 1.00 127.20 ?  136 LEU A CD2 1 
ATOM   822  N N   . ALA A 1 137 ? 96.659  95.929  109.829 1.00 124.34 ?  137 ALA A N   1 
ATOM   823  C CA  . ALA A 1 137 ? 97.148  96.263  108.497 1.00 128.36 ?  137 ALA A CA  1 
ATOM   824  C C   . ALA A 1 137 ? 98.332  97.215  108.568 1.00 131.64 ?  137 ALA A C   1 
ATOM   825  O O   . ALA A 1 137 ? 99.401  96.919  108.017 1.00 135.29 ?  137 ALA A O   1 
ATOM   826  C CB  . ALA A 1 137 ? 96.023  96.869  107.661 1.00 122.09 ?  137 ALA A CB  1 
ATOM   827  N N   . GLN A 1 138 ? 98.190  98.323  109.303 1.00 120.81 ?  138 GLN A N   1 
ATOM   828  C CA  . GLN A 1 138 ? 99.305  99.259  109.409 1.00 122.35 ?  138 GLN A CA  1 
ATOM   829  C C   . GLN A 1 138 ? 100.540 98.581  109.975 1.00 114.00 ?  138 GLN A C   1 
ATOM   830  O O   . GLN A 1 138 ? 101.649 98.778  109.463 1.00 116.76 ?  138 GLN A O   1 
ATOM   831  C CB  . GLN A 1 138 ? 98.936  100.474 110.256 1.00 122.15 ?  138 GLN A CB  1 
ATOM   832  C CG  . GLN A 1 138 ? 100.149 101.341 110.555 1.00 115.96 ?  138 GLN A CG  1 
ATOM   833  C CD  . GLN A 1 138 ? 100.661 102.107 109.351 1.00 125.68 ?  138 GLN A CD  1 
ATOM   834  O OE1 . GLN A 1 138 ? 100.084 102.045 108.263 1.00 138.10 ?  138 GLN A OE1 1 
ATOM   835  N NE2 . GLN A 1 138 ? 101.777 102.798 109.527 1.00 119.39 ?  138 GLN A NE2 1 
ATOM   836  N N   . SER A 1 139 ? 100.370 97.765  111.019 1.00 97.03  ?  139 SER A N   1 
ATOM   837  C CA  . SER A 1 139 ? 101.511 97.023  111.536 1.00 104.05 ?  139 SER A CA  1 
ATOM   838  C C   . SER A 1 139 ? 102.191 96.264  110.412 1.00 111.95 ?  139 SER A C   1 
ATOM   839  O O   . SER A 1 139 ? 103.384 96.469  110.147 1.00 121.74 ?  139 SER A O   1 
ATOM   840  C CB  . SER A 1 139 ? 101.063 96.065  112.637 1.00 111.66 ?  139 SER A CB  1 
ATOM   841  O OG  . SER A 1 139 ? 102.159 95.333  113.153 1.00 112.56 ?  139 SER A OG  1 
ATOM   842  N N   . LEU A 1 140 ? 101.412 95.479  109.665 1.00 111.75 ?  140 LEU A N   1 
ATOM   843  C CA  . LEU A 1 140 ? 101.972 94.730  108.550 1.00 113.67 ?  140 LEU A CA  1 
ATOM   844  C C   . LEU A 1 140 ? 102.695 95.663  107.595 1.00 116.63 ?  140 LEU A C   1 
ATOM   845  O O   . LEU A 1 140 ? 103.820 95.374  107.167 1.00 116.17 ?  140 LEU A O   1 
ATOM   846  C CB  . LEU A 1 140 ? 100.865 93.962  107.832 1.00 110.97 ?  140 LEU A CB  1 
ATOM   847  C CG  . LEU A 1 140 ? 100.886 92.443  107.992 1.00 108.51 ?  140 LEU A CG  1 
ATOM   848  C CD1 . LEU A 1 140 ? 100.071 91.785  106.898 1.00 108.34 ?  140 LEU A CD1 1 
ATOM   849  C CD2 . LEU A 1 140 ? 102.309 91.928  107.976 1.00 103.55 ?  140 LEU A CD2 1 
ATOM   850  N N   . TYR A 1 141 ? 102.094 96.821  107.307 1.00 105.97 ?  141 TYR A N   1 
ATOM   851  C CA  . TYR A 1 141 ? 102.739 97.776  106.417 1.00 98.25  ?  141 TYR A CA  1 
ATOM   852  C C   . TYR A 1 141 ? 104.141 98.109  106.898 1.00 110.42 ?  141 TYR A C   1 
ATOM   853  O O   . TYR A 1 141 ? 105.116 97.924  106.159 1.00 120.64 ?  141 TYR A O   1 
ATOM   854  C CB  . TYR A 1 141 ? 101.899 99.046  106.308 1.00 93.87  ?  141 TYR A CB  1 
ATOM   855  C CG  . TYR A 1 141 ? 102.642 100.220 105.713 1.00 108.80 ?  141 TYR A CG  1 
ATOM   856  C CD1 . TYR A 1 141 ? 102.740 100.376 104.343 1.00 116.78 ?  141 TYR A CD1 1 
ATOM   857  C CD2 . TYR A 1 141 ? 103.231 101.180 106.522 1.00 109.38 ?  141 TYR A CD2 1 
ATOM   858  C CE1 . TYR A 1 141 ? 103.411 101.446 103.792 1.00 116.13 ?  141 TYR A CE1 1 
ATOM   859  C CE2 . TYR A 1 141 ? 103.906 102.253 105.978 1.00 106.34 ?  141 TYR A CE2 1 
ATOM   860  C CZ  . TYR A 1 141 ? 103.993 102.380 104.614 1.00 108.43 ?  141 TYR A CZ  1 
ATOM   861  O OH  . TYR A 1 141 ? 104.663 103.450 104.071 1.00 110.90 ?  141 TYR A OH  1 
ATOM   862  N N   . MET A 1 142 ? 104.280 98.534  108.157 1.00 111.17 ?  142 MET A N   1 
ATOM   863  C CA  . MET A 1 142 ? 105.617 98.917  108.591 1.00 110.40 ?  142 MET A CA  1 
ATOM   864  C C   . MET A 1 142 ? 106.513 97.706  108.746 1.00 104.89 ?  142 MET A C   1 
ATOM   865  O O   . MET A 1 142 ? 107.740 97.841  108.685 1.00 117.96 ?  142 MET A O   1 
ATOM   866  C CB  . MET A 1 142 ? 105.584 99.730  109.882 1.00 115.19 ?  142 MET A CB  1 
ATOM   867  C CG  . MET A 1 142 ? 104.605 100.874 109.875 1.00 117.84 ?  142 MET A CG  1 
ATOM   868  S SD  . MET A 1 142 ? 105.362 102.318 109.098 1.00 119.17 ?  142 MET A SD  1 
ATOM   869  C CE  . MET A 1 142 ? 107.016 102.286 109.786 1.00 110.79 ?  142 MET A CE  1 
ATOM   870  N N   . VAL A 1 143 ? 105.928 96.518  108.913 1.00 97.77  ?  143 VAL A N   1 
ATOM   871  C CA  . VAL A 1 143 ? 106.740 95.310  108.862 1.00 103.59 ?  143 VAL A CA  1 
ATOM   872  C C   . VAL A 1 143 ? 107.498 95.269  107.548 1.00 110.62 ?  143 VAL A C   1 
ATOM   873  O O   . VAL A 1 143 ? 108.726 95.108  107.526 1.00 111.61 ?  143 VAL A O   1 
ATOM   874  C CB  . VAL A 1 143 ? 105.864 94.060  109.055 1.00 112.75 ?  143 VAL A CB  1 
ATOM   875  C CG1 . VAL A 1 143 ? 106.488 92.862  108.359 1.00 110.20 ?  143 VAL A CG1 1 
ATOM   876  C CG2 . VAL A 1 143 ? 105.668 93.781  110.534 1.00 122.61 ?  143 VAL A CG2 1 
ATOM   877  N N   . GLY A 1 144 ? 106.791 95.502  106.440 1.00 118.34 ?  144 GLY A N   1 
ATOM   878  C CA  . GLY A 1 144 ? 107.468 95.600  105.162 1.00 118.60 ?  144 GLY A CA  1 
ATOM   879  C C   . GLY A 1 144 ? 108.557 96.650  105.189 1.00 111.08 ?  144 GLY A C   1 
ATOM   880  O O   . GLY A 1 144 ? 109.678 96.405  104.733 1.00 112.67 ?  144 GLY A O   1 
ATOM   881  N N   . VAL A 1 145 ? 108.265 97.805  105.796 1.00 98.96  ?  145 VAL A N   1 
ATOM   882  C CA  . VAL A 1 145 ? 109.272 98.853  105.911 1.00 103.86 ?  145 VAL A CA  1 
ATOM   883  C C   . VAL A 1 145 ? 110.521 98.296  106.572 1.00 104.64 ?  145 VAL A C   1 
ATOM   884  O O   . VAL A 1 145 ? 111.630 98.422  106.039 1.00 110.97 ?  145 VAL A O   1 
ATOM   885  C CB  . VAL A 1 145 ? 108.709 100.059 106.688 1.00 111.17 ?  145 VAL A CB  1 
ATOM   886  C CG1 . VAL A 1 145 ? 109.824 100.815 107.381 1.00 109.48 ?  145 VAL A CG1 1 
ATOM   887  C CG2 . VAL A 1 145 ? 107.945 100.987 105.767 1.00 112.11 ?  145 VAL A CG2 1 
ATOM   888  N N   . LEU A 1 146 ? 110.351 97.599  107.699 1.00 116.71 ?  146 LEU A N   1 
ATOM   889  C CA  . LEU A 1 146 ? 111.505 97.006  108.362 1.00 114.96 ?  146 LEU A CA  1 
ATOM   890  C C   . LEU A 1 146 ? 112.224 96.056  107.421 1.00 118.11 ?  146 LEU A C   1 
ATOM   891  O O   . LEU A 1 146 ? 113.446 96.140  107.250 1.00 117.03 ?  146 LEU A O   1 
ATOM   892  C CB  . LEU A 1 146 ? 111.069 96.284  109.635 1.00 113.75 ?  146 LEU A CB  1 
ATOM   893  C CG  . LEU A 1 146 ? 112.192 95.644  110.445 1.00 107.06 ?  146 LEU A CG  1 
ATOM   894  C CD1 . LEU A 1 146 ? 112.722 96.638  111.454 1.00 113.21 ?  146 LEU A CD1 1 
ATOM   895  C CD2 . LEU A 1 146 ? 111.696 94.393  111.139 1.00 112.72 ?  146 LEU A CD2 1 
ATOM   896  N N   . LEU A 1 147 ? 111.468 95.184  106.752 1.00 128.11 ?  147 LEU A N   1 
ATOM   897  C CA  . LEU A 1 147 ? 112.080 94.290  105.779 1.00 132.10 ?  147 LEU A CA  1 
ATOM   898  C C   . LEU A 1 147 ? 112.702 95.090  104.645 1.00 130.98 ?  147 LEU A C   1 
ATOM   899  O O   . LEU A 1 147 ? 113.825 94.803  104.212 1.00 127.17 ?  147 LEU A O   1 
ATOM   900  C CB  . LEU A 1 147 ? 111.039 93.302  105.254 1.00 124.55 ?  147 LEU A CB  1 
ATOM   901  C CG  . LEU A 1 147 ? 111.515 92.237  104.270 1.00 126.84 ?  147 LEU A CG  1 
ATOM   902  C CD1 . LEU A 1 147 ? 112.792 91.593  104.773 1.00 128.18 ?  147 LEU A CD1 1 
ATOM   903  C CD2 . LEU A 1 147 ? 110.433 91.191  104.065 1.00 128.18 ?  147 LEU A CD2 1 
ATOM   904  N N   . GLY A 1 148 ? 112.008 96.135  104.190 1.00 130.83 ?  148 GLY A N   1 
ATOM   905  C CA  . GLY A 1 148 ? 112.565 96.973  103.144 1.00 131.03 ?  148 GLY A CA  1 
ATOM   906  C C   . GLY A 1 148 ? 113.809 97.703  103.603 1.00 127.56 ?  148 GLY A C   1 
ATOM   907  O O   . GLY A 1 148 ? 114.636 98.116  102.786 1.00 125.26 ?  148 GLY A O   1 
ATOM   908  N N   . ALA A 1 149 ? 113.960 97.873  104.917 1.00 131.25 ?  149 ALA A N   1 
ATOM   909  C CA  . ALA A 1 149 ? 115.184 98.469  105.432 1.00 132.53 ?  149 ALA A CA  1 
ATOM   910  C C   . ALA A 1 149 ? 116.355 97.510  105.296 1.00 138.73 ?  149 ALA A C   1 
ATOM   911  O O   . ALA A 1 149 ? 117.491 97.934  105.057 1.00 143.38 ?  149 ALA A O   1 
ATOM   912  C CB  . ALA A 1 149 ? 114.997 98.883  106.889 1.00 137.01 ?  149 ALA A CB  1 
ATOM   913  N N   . MET A 1 150 ? 116.101 96.208  105.441 1.00 139.86 ?  150 MET A N   1 
ATOM   914  C CA  . MET A 1 150 ? 117.207 95.261  105.453 1.00 144.37 ?  150 MET A CA  1 
ATOM   915  C C   . MET A 1 150 ? 117.513 94.738  104.056 1.00 142.78 ?  150 MET A C   1 
ATOM   916  O O   . MET A 1 150 ? 118.594 94.995  103.515 1.00 144.42 ?  150 MET A O   1 
ATOM   917  C CB  . MET A 1 150 ? 116.893 94.104  106.405 1.00 139.72 ?  150 MET A CB  1 
ATOM   918  C CG  . MET A 1 150 ? 116.621 94.497  107.863 1.00 141.39 ?  150 MET A CG  1 
ATOM   919  S SD  . MET A 1 150 ? 117.312 96.035  108.536 1.00 149.79 ?  150 MET A SD  1 
ATOM   920  C CE  . MET A 1 150 ? 119.067 95.917  108.167 1.00 143.81 ?  150 MET A CE  1 
ATOM   921  N N   . VAL A 1 151 ? 116.553 94.044  103.441 1.00 133.68 ?  151 VAL A N   1 
ATOM   922  C CA  . VAL A 1 151 ? 116.829 93.334  102.194 1.00 138.11 ?  151 VAL A CA  1 
ATOM   923  C C   . VAL A 1 151 ? 117.249 94.315  101.109 1.00 142.38 ?  151 VAL A C   1 
ATOM   924  O O   . VAL A 1 151 ? 118.321 94.182  100.504 1.00 146.94 ?  151 VAL A O   1 
ATOM   925  C CB  . VAL A 1 151 ? 115.605 92.507  101.764 1.00 136.36 ?  151 VAL A CB  1 
ATOM   926  C CG1 . VAL A 1 151 ? 115.574 92.332  100.252 1.00 132.89 ?  151 VAL A CG1 1 
ATOM   927  C CG2 . VAL A 1 151 ? 115.612 91.156  102.460 1.00 138.70 ?  151 VAL A CG2 1 
ATOM   928  N N   . PHE A 1 152 ? 116.441 95.353  100.889 1.00 134.15 ?  152 PHE A N   1 
ATOM   929  C CA  . PHE A 1 152 ? 116.779 96.303  99.839  1.00 132.44 ?  152 PHE A CA  1 
ATOM   930  C C   . PHE A 1 152 ? 117.950 97.181  100.246 1.00 135.91 ?  152 PHE A C   1 
ATOM   931  O O   . PHE A 1 152 ? 118.502 97.904  99.410  1.00 139.27 ?  152 PHE A O   1 
ATOM   932  C CB  . PHE A 1 152 ? 115.562 97.144  99.467  1.00 124.17 ?  152 PHE A CB  1 
ATOM   933  C CG  . PHE A 1 152 ? 114.726 96.527  98.389  1.00 127.82 ?  152 PHE A CG  1 
ATOM   934  C CD1 . PHE A 1 152 ? 114.883 96.907  97.071  1.00 133.11 ?  152 PHE A CD1 1 
ATOM   935  C CD2 . PHE A 1 152 ? 113.786 95.561  98.694  1.00 132.66 ?  152 PHE A CD2 1 
ATOM   936  C CE1 . PHE A 1 152 ? 114.117 96.335  96.075  1.00 133.83 ?  152 PHE A CE1 1 
ATOM   937  C CE2 . PHE A 1 152 ? 113.016 94.988  97.703  1.00 136.04 ?  152 PHE A CE2 1 
ATOM   938  C CZ  . PHE A 1 152 ? 113.182 95.376  96.392  1.00 132.78 ?  152 PHE A CZ  1 
ATOM   939  N N   . GLY A 1 153 ? 118.341 97.140  101.520 1.00 138.84 ?  153 GLY A N   1 
ATOM   940  C CA  . GLY A 1 153 ? 119.635 97.683  101.885 1.00 138.58 ?  153 GLY A CA  1 
ATOM   941  C C   . GLY A 1 153 ? 120.766 96.850  101.319 1.00 140.29 ?  153 GLY A C   1 
ATOM   942  O O   . GLY A 1 153 ? 121.659 97.373  100.646 1.00 139.83 ?  153 GLY A O   1 
ATOM   943  N N   . TYR A 1 154 ? 120.718 95.532  101.543 1.00 157.33 ?  154 TYR A N   1 
ATOM   944  C CA  . TYR A 1 154 ? 121.784 94.661  101.060 1.00 158.59 ?  154 TYR A CA  1 
ATOM   945  C C   . TYR A 1 154 ? 121.862 94.681  99.542  1.00 156.88 ?  154 TYR A C   1 
ATOM   946  O O   . TYR A 1 154 ? 122.957 94.736  98.972  1.00 162.05 ?  154 TYR A O   1 
ATOM   947  C CB  . TYR A 1 154 ? 121.572 93.235  101.563 1.00 159.08 ?  154 TYR A CB  1 
ATOM   948  C CG  . TYR A 1 154 ? 122.347 92.204  100.779 1.00 158.33 ?  154 TYR A CG  1 
ATOM   949  C CD1 . TYR A 1 154 ? 123.725 92.096  100.911 1.00 156.95 ?  154 TYR A CD1 1 
ATOM   950  C CD2 . TYR A 1 154 ? 121.704 91.340  99.905  1.00 157.18 ?  154 TYR A CD2 1 
ATOM   951  C CE1 . TYR A 1 154 ? 124.439 91.157  100.195 1.00 156.91 ?  154 TYR A CE1 1 
ATOM   952  C CE2 . TYR A 1 154 ? 122.409 90.398  99.185  1.00 159.77 ?  154 TYR A CE2 1 
ATOM   953  C CZ  . TYR A 1 154 ? 123.776 90.311  99.334  1.00 160.55 ?  154 TYR A CZ  1 
ATOM   954  O OH  . TYR A 1 154 ? 124.483 89.372  98.618  1.00 162.52 ?  154 TYR A OH  1 
ATOM   955  N N   . LEU A 1 155 ? 120.709 94.643  98.872  1.00 136.64 ?  155 LEU A N   1 
ATOM   956  C CA  . LEU A 1 155 ? 120.696 94.762  97.420  1.00 140.50 ?  155 LEU A CA  1 
ATOM   957  C C   . LEU A 1 155 ? 121.353 96.058  96.966  1.00 145.85 ?  155 LEU A C   1 
ATOM   958  O O   . LEU A 1 155 ? 122.002 96.085  95.914  1.00 148.24 ?  155 LEU A O   1 
ATOM   959  C CB  . LEU A 1 155 ? 119.263 94.683  96.899  1.00 135.50 ?  155 LEU A CB  1 
ATOM   960  C CG  . LEU A 1 155 ? 118.885 93.437  96.097  1.00 137.05 ?  155 LEU A CG  1 
ATOM   961  C CD1 . LEU A 1 155 ? 117.678 93.723  95.221  1.00 144.37 ?  155 LEU A CD1 1 
ATOM   962  C CD2 . LEU A 1 155 ? 120.054 92.949  95.262  1.00 138.53 ?  155 LEU A CD2 1 
ATOM   963  N N   . ALA A 1 156 ? 121.217 97.129  97.752  1.00 141.15 ?  156 ALA A N   1 
ATOM   964  C CA  . ALA A 1 156 ? 121.839 98.396  97.383  1.00 142.29 ?  156 ALA A CA  1 
ATOM   965  C C   . ALA A 1 156 ? 123.353 98.263  97.303  1.00 142.09 ?  156 ALA A C   1 
ATOM   966  O O   . ALA A 1 156 ? 124.007 98.995  96.552  1.00 142.30 ?  156 ALA A O   1 
ATOM   967  C CB  . ALA A 1 156 ? 121.445 99.485  98.379  1.00 142.43 ?  156 ALA A CB  1 
ATOM   968  N N   . ASP A 1 157 ? 123.928 97.334  98.066  1.00 144.39 ?  157 ASP A N   1 
ATOM   969  C CA  . ASP A 1 157 ? 125.370 97.136  98.032  1.00 144.61 ?  157 ASP A CA  1 
ATOM   970  C C   . ASP A 1 157 ? 125.792 96.142  96.959  1.00 145.14 ?  157 ASP A C   1 
ATOM   971  O O   . ASP A 1 157 ? 126.995 95.945  96.757  1.00 152.04 ?  157 ASP A O   1 
ATOM   972  C CB  . ASP A 1 157 ? 125.867 96.667  99.399  1.00 150.78 ?  157 ASP A CB  1 
ATOM   973  C CG  . ASP A 1 157 ? 125.970 97.800  100.402 1.00 151.25 ?  157 ASP A CG  1 
ATOM   974  O OD1 . ASP A 1 157 ? 125.894 98.973  99.984  1.00 149.95 ?  157 ASP A OD1 1 
ATOM   975  O OD2 . ASP A 1 157 ? 126.124 97.516  101.608 1.00 152.71 -1 157 ASP A OD2 1 
ATOM   976  N N   . ARG A 1 158 ? 124.842 95.510  96.274  1.00 143.63 ?  158 ARG A N   1 
ATOM   977  C CA  . ARG A 1 158 ? 125.160 94.462  95.311  1.00 149.24 ?  158 ARG A CA  1 
ATOM   978  C C   . ARG A 1 158 ? 124.817 94.833  93.876  1.00 151.70 ?  158 ARG A C   1 
ATOM   979  O O   . ARG A 1 158 ? 125.456 94.332  92.947  1.00 154.53 ?  158 ARG A O   1 
ATOM   980  C CB  . ARG A 1 158 ? 124.438 93.166  95.688  1.00 151.71 ?  158 ARG A CB  1 
ATOM   981  C CG  . ARG A 1 158 ? 125.098 91.906  95.153  1.00 148.24 ?  158 ARG A CG  1 
ATOM   982  C CD  . ARG A 1 158 ? 124.198 90.693  95.330  1.00 150.98 ?  158 ARG A CD  1 
ATOM   983  N NE  . ARG A 1 158 ? 124.426 89.687  94.299  1.00 154.97 ?  158 ARG A NE  1 
ATOM   984  C CZ  . ARG A 1 158 ? 123.495 88.863  93.837  1.00 156.01 ?  158 ARG A CZ  1 
ATOM   985  N NH1 . ARG A 1 158 ? 122.255 88.894  94.297  1.00 151.05 1  158 ARG A NH1 1 
ATOM   986  N NH2 . ARG A 1 158 ? 123.817 87.986  92.891  1.00 156.40 ?  158 ARG A NH2 1 
ATOM   987  N N   . LEU A 1 159 ? 123.819 95.692  93.666  1.00 135.97 ?  159 LEU A N   1 
ATOM   988  C CA  . LEU A 1 159 ? 123.389 96.060  92.324  1.00 135.91 ?  159 LEU A CA  1 
ATOM   989  C C   . LEU A 1 159 ? 123.594 97.530  91.993  1.00 135.69 ?  159 LEU A C   1 
ATOM   990  O O   . LEU A 1 159 ? 123.403 97.916  90.835  1.00 135.80 ?  159 LEU A O   1 
ATOM   991  C CB  . LEU A 1 159 ? 121.907 95.706  92.126  1.00 139.19 ?  159 LEU A CB  1 
ATOM   992  C CG  . LEU A 1 159 ? 121.566 94.217  92.081  1.00 138.62 ?  159 LEU A CG  1 
ATOM   993  C CD1 . LEU A 1 159 ? 120.150 94.010  91.567  1.00 140.17 ?  159 LEU A CD1 1 
ATOM   994  C CD2 . LEU A 1 159 ? 122.568 93.464  91.222  1.00 135.29 ?  159 LEU A CD2 1 
ATOM   995  N N   . GLY A 1 160 ? 123.970 98.356  92.964  1.00 142.36 ?  160 GLY A N   1 
ATOM   996  C CA  . GLY A 1 160 ? 124.131 99.776  92.722  1.00 146.06 ?  160 GLY A CA  1 
ATOM   997  C C   . GLY A 1 160 ? 122.954 100.580 93.228  1.00 149.91 ?  160 GLY A C   1 
ATOM   998  O O   . GLY A 1 160 ? 121.820 100.094 93.224  1.00 156.04 ?  160 GLY A O   1 
ATOM   999  N N   . ARG A 1 161 ? 123.207 101.816 93.664  1.00 142.69 ?  161 ARG A N   1 
ATOM   1000 C CA  . ARG A 1 161 ? 122.142 102.626 94.246  1.00 140.55 ?  161 ARG A CA  1 
ATOM   1001 C C   . ARG A 1 161 ? 121.068 102.959 93.219  1.00 143.74 ?  161 ARG A C   1 
ATOM   1002 O O   . ARG A 1 161 ? 119.872 102.934 93.531  1.00 154.09 ?  161 ARG A O   1 
ATOM   1003 C CB  . ARG A 1 161 ? 122.722 103.906 94.846  1.00 139.79 ?  161 ARG A CB  1 
ATOM   1004 C CG  . ARG A 1 161 ? 123.781 103.683 95.916  1.00 143.76 ?  161 ARG A CG  1 
ATOM   1005 C CD  . ARG A 1 161 ? 123.439 102.505 96.817  1.00 142.84 ?  161 ARG A CD  1 
ATOM   1006 N NE  . ARG A 1 161 ? 124.021 102.636 98.148  1.00 150.01 ?  161 ARG A NE  1 
ATOM   1007 C CZ  . ARG A 1 161 ? 125.312 102.511 98.424  1.00 150.63 ?  161 ARG A CZ  1 
ATOM   1008 N NH1 . ARG A 1 161 ? 126.198 102.238 97.481  1.00 151.49 1  161 ARG A NH1 1 
ATOM   1009 N NH2 . ARG A 1 161 ? 125.724 102.657 99.679  1.00 147.95 ?  161 ARG A NH2 1 
ATOM   1010 N N   . ARG A 1 162 ? 121.472 103.277 91.989  1.00 127.83 ?  162 ARG A N   1 
ATOM   1011 C CA  . ARG A 1 162 ? 120.512 103.714 90.980  1.00 131.07 ?  162 ARG A CA  1 
ATOM   1012 C C   . ARG A 1 162 ? 119.557 102.591 90.585  1.00 138.81 ?  162 ARG A C   1 
ATOM   1013 O O   . ARG A 1 162 ? 118.347 102.813 90.452  1.00 145.43 ?  162 ARG A O   1 
ATOM   1014 C CB  . ARG A 1 162 ? 121.253 104.252 89.759  1.00 133.37 ?  162 ARG A CB  1 
ATOM   1015 C CG  . ARG A 1 162 ? 120.385 104.436 88.535  1.00 135.79 ?  162 ARG A CG  1 
ATOM   1016 C CD  . ARG A 1 162 ? 121.226 104.859 87.350  1.00 139.03 ?  162 ARG A CD  1 
ATOM   1017 N NE  . ARG A 1 162 ? 120.687 104.366 86.090  1.00 141.89 ?  162 ARG A NE  1 
ATOM   1018 C CZ  . ARG A 1 162 ? 120.883 103.140 85.627  1.00 142.39 ?  162 ARG A CZ  1 
ATOM   1019 N NH1 . ARG A 1 162 ? 121.601 102.255 86.297  1.00 136.57 1  162 ARG A NH1 1 
ATOM   1020 N NH2 . ARG A 1 162 ? 120.346 102.794 84.461  1.00 147.08 ?  162 ARG A NH2 1 
ATOM   1021 N N   . LYS A 1 163 ? 120.079 101.379 90.382  1.00 137.59 ?  163 LYS A N   1 
ATOM   1022 C CA  . LYS A 1 163 ? 119.210 100.266 90.009  1.00 137.20 ?  163 LYS A CA  1 
ATOM   1023 C C   . LYS A 1 163 ? 118.210 99.949  91.112  1.00 137.61 ?  163 LYS A C   1 
ATOM   1024 O O   . LYS A 1 163 ? 117.030 99.697  90.836  1.00 144.73 ?  163 LYS A O   1 
ATOM   1025 C CB  . LYS A 1 163 ? 120.040 99.029  89.674  1.00 134.53 ?  163 LYS A CB  1 
ATOM   1026 C CG  . LYS A 1 163 ? 120.820 99.132  88.380  1.00 138.65 ?  163 LYS A CG  1 
ATOM   1027 C CD  . LYS A 1 163 ? 121.417 97.788  88.002  1.00 142.85 ?  163 LYS A CD  1 
ATOM   1028 C CE  . LYS A 1 163 ? 122.388 97.918  86.842  1.00 147.23 ?  163 LYS A CE  1 
ATOM   1029 N NZ  . LYS A 1 163 ? 123.053 96.622  86.536  1.00 143.38 1  163 LYS A NZ  1 
ATOM   1030 N N   . VAL A 1 164 ? 118.661 99.949  92.366  1.00 111.36 ?  164 VAL A N   1 
ATOM   1031 C CA  . VAL A 1 164 ? 117.753 99.663  93.470  1.00 110.59 ?  164 VAL A CA  1 
ATOM   1032 C C   . VAL A 1 164 ? 116.725 100.777 93.613  1.00 110.15 ?  164 VAL A C   1 
ATOM   1033 O O   . VAL A 1 164 ? 115.563 100.525 93.944  1.00 121.26 ?  164 VAL A O   1 
ATOM   1034 C CB  . VAL A 1 164 ? 118.539 99.434  94.771  1.00 111.58 ?  164 VAL A CB  1 
ATOM   1035 C CG1 . VAL A 1 164 ? 117.590 99.135  95.911  1.00 121.09 ?  164 VAL A CG1 1 
ATOM   1036 C CG2 . VAL A 1 164 ? 119.508 98.285  94.591  1.00 114.07 ?  164 VAL A CG2 1 
ATOM   1037 N N   . LEU A 1 165 ? 117.126 102.023 93.355  1.00 95.11  ?  165 LEU A N   1 
ATOM   1038 C CA  . LEU A 1 165 ? 116.157 103.114 93.365  1.00 100.20 ?  165 LEU A CA  1 
ATOM   1039 C C   . LEU A 1 165 ? 115.106 102.926 92.279  1.00 111.30 ?  165 LEU A C   1 
ATOM   1040 O O   . LEU A 1 165 ? 113.914 103.160 92.509  1.00 128.64 ?  165 LEU A O   1 
ATOM   1041 C CB  . LEU A 1 165 ? 116.865 104.455 93.192  1.00 107.78 ?  165 LEU A CB  1 
ATOM   1042 C CG  . LEU A 1 165 ? 117.144 105.245 94.469  1.00 114.96 ?  165 LEU A CG  1 
ATOM   1043 C CD1 . LEU A 1 165 ? 117.922 106.505 94.149  1.00 124.98 ?  165 LEU A CD1 1 
ATOM   1044 C CD2 . LEU A 1 165 ? 115.850 105.585 95.176  1.00 107.60 ?  165 LEU A CD2 1 
ATOM   1045 N N   . ILE A 1 166 ? 115.530 102.509 91.085  1.00 102.85 ?  166 ILE A N   1 
ATOM   1046 C CA  . ILE A 1 166 ? 114.588 102.286 89.991  1.00 102.87 ?  166 ILE A CA  1 
ATOM   1047 C C   . ILE A 1 166 ? 113.607 101.177 90.355  1.00 111.64 ?  166 ILE A C   1 
ATOM   1048 O O   . ILE A 1 166 ? 112.391 101.296 90.145  1.00 116.48 ?  166 ILE A O   1 
ATOM   1049 C CB  . ILE A 1 166 ? 115.350 101.966 88.693  1.00 100.71 ?  166 ILE A CB  1 
ATOM   1050 C CG1 . ILE A 1 166 ? 115.693 103.254 87.950  1.00 103.81 ?  166 ILE A CG1 1 
ATOM   1051 C CG2 . ILE A 1 166 ? 114.542 101.041 87.801  1.00 108.79 ?  166 ILE A CG2 1 
ATOM   1052 C CD1 . ILE A 1 166 ? 116.653 103.051 86.812  1.00 113.01 ?  166 ILE A CD1 1 
ATOM   1053 N N   . LEU A 1 167 ? 114.125 100.081 90.912  1.00 112.05 ?  167 LEU A N   1 
ATOM   1054 C CA  . LEU A 1 167 ? 113.250 98.990  91.321  1.00 106.58 ?  167 LEU A CA  1 
ATOM   1055 C C   . LEU A 1 167 ? 112.316 99.412  92.446  1.00 113.51 ?  167 LEU A C   1 
ATOM   1056 O O   . LEU A 1 167 ? 111.166 98.971  92.482  1.00 118.37 ?  167 LEU A O   1 
ATOM   1057 C CB  . LEU A 1 167 ? 114.073 97.773  91.736  1.00 104.02 ?  167 LEU A CB  1 
ATOM   1058 C CG  . LEU A 1 167 ? 114.899 97.143  90.616  1.00 109.01 ?  167 LEU A CG  1 
ATOM   1059 C CD1 . LEU A 1 167 ? 115.660 95.930  91.123  1.00 112.38 ?  167 LEU A CD1 1 
ATOM   1060 C CD2 . LEU A 1 167 ? 114.010 96.776  89.442  1.00 107.96 ?  167 LEU A CD2 1 
ATOM   1061 N N   . ASN A 1 168 ? 112.783 100.257 93.366  1.00 108.86 ?  168 ASN A N   1 
ATOM   1062 C CA  . ASN A 1 168 ? 111.905 100.761 94.417  1.00 97.54  ?  168 ASN A CA  1 
ATOM   1063 C C   . ASN A 1 168 ? 110.789 101.621 93.845  1.00 103.11 ?  168 ASN A C   1 
ATOM   1064 O O   . ASN A 1 168 ? 109.639 101.511 94.276  1.00 125.66 ?  168 ASN A O   1 
ATOM   1065 C CB  . ASN A 1 168 ? 112.707 101.546 95.450  1.00 103.93 ?  168 ASN A CB  1 
ATOM   1066 C CG  . ASN A 1 168 ? 113.643 100.671 96.238  1.00 112.58 ?  168 ASN A CG  1 
ATOM   1067 O OD1 . ASN A 1 168 ? 114.562 101.153 96.899  1.00 119.38 ?  168 ASN A OD1 1 
ATOM   1068 N ND2 . ASN A 1 168 ? 113.409 99.373  96.182  1.00 105.87 ?  168 ASN A ND2 1 
ATOM   1069 N N   . TYR A 1 169 ? 111.105 102.483 92.877  1.00 89.49  ?  169 TYR A N   1 
ATOM   1070 C CA  . TYR A 1 169 ? 110.056 103.274 92.239  1.00 95.02  ?  169 TYR A CA  1 
ATOM   1071 C C   . TYR A 1 169 ? 109.024 102.376 91.573  1.00 103.72 ?  169 TYR A C   1 
ATOM   1072 O O   . TYR A 1 169 ? 107.814 102.549 91.773  1.00 106.78 ?  169 TYR A O   1 
ATOM   1073 C CB  . TYR A 1 169 ? 110.655 104.233 91.212  1.00 96.11  ?  169 TYR A CB  1 
ATOM   1074 C CG  . TYR A 1 169 ? 111.403 105.403 91.799  1.00 102.09 ?  169 TYR A CG  1 
ATOM   1075 C CD1 . TYR A 1 169 ? 110.826 106.206 92.768  1.00 96.40  ?  169 TYR A CD1 1 
ATOM   1076 C CD2 . TYR A 1 169 ? 112.683 105.713 91.371  1.00 116.96 ?  169 TYR A CD2 1 
ATOM   1077 C CE1 . TYR A 1 169 ? 111.507 107.279 93.299  1.00 103.27 ?  169 TYR A CE1 1 
ATOM   1078 C CE2 . TYR A 1 169 ? 113.372 106.777 91.899  1.00 110.33 ?  169 TYR A CE2 1 
ATOM   1079 C CZ  . TYR A 1 169 ? 112.782 107.557 92.862  1.00 110.21 ?  169 TYR A CZ  1 
ATOM   1080 O OH  . TYR A 1 169 ? 113.473 108.622 93.386  1.00 124.82 ?  169 TYR A OH  1 
ATOM   1081 N N   . LEU A 1 170 ? 109.485 101.402 90.784  1.00 102.83 ?  170 LEU A N   1 
ATOM   1082 C CA  . LEU A 1 170 ? 108.549 100.522 90.091  1.00 108.95 ?  170 LEU A CA  1 
ATOM   1083 C C   . LEU A 1 170 ? 107.711 99.717  91.077  1.00 114.16 ?  170 LEU A C   1 
ATOM   1084 O O   . LEU A 1 170 ? 106.494 99.582  90.898  1.00 117.72 ?  170 LEU A O   1 
ATOM   1085 C CB  . LEU A 1 170 ? 109.303 99.594  89.137  1.00 107.83 ?  170 LEU A CB  1 
ATOM   1086 C CG  . LEU A 1 170 ? 108.503 98.548  88.356  1.00 110.98 ?  170 LEU A CG  1 
ATOM   1087 C CD1 . LEU A 1 170 ? 109.149 98.314  87.007  1.00 111.16 ?  170 LEU A CD1 1 
ATOM   1088 C CD2 . LEU A 1 170 ? 108.411 97.229  89.111  1.00 108.64 ?  170 LEU A CD2 1 
ATOM   1089 N N   . GLN A 1 171 ? 108.344 99.171  92.118  1.00 108.37 ?  171 GLN A N   1 
ATOM   1090 C CA  . GLN A 1 171 ? 107.621 98.364  93.092  1.00 105.10 ?  171 GLN A CA  1 
ATOM   1091 C C   . GLN A 1 171 ? 106.614 99.201  93.864  1.00 115.87 ?  171 GLN A C   1 
ATOM   1092 O O   . GLN A 1 171 ? 105.484 98.758  94.088  1.00 115.06 ?  171 GLN A O   1 
ATOM   1093 C CB  . GLN A 1 171 ? 108.600 97.686  94.047  1.00 96.91  ?  171 GLN A CB  1 
ATOM   1094 C CG  . GLN A 1 171 ? 107.939 96.762  95.048  1.00 99.03  ?  171 GLN A CG  1 
ATOM   1095 C CD  . GLN A 1 171 ? 108.932 96.125  95.992  1.00 110.12 ?  171 GLN A CD  1 
ATOM   1096 O OE1 . GLN A 1 171 ? 110.112 95.994  95.672  1.00 121.27 ?  171 GLN A OE1 1 
ATOM   1097 N NE2 . GLN A 1 171 ? 108.462 95.728  97.168  1.00 111.69 ?  171 GLN A NE2 1 
ATOM   1098 N N   . THR A 1 172 ? 106.994 100.415 94.270  1.00 120.75 ?  172 THR A N   1 
ATOM   1099 C CA  . THR A 1 172 ? 106.045 101.287 94.949  1.00 110.47 ?  172 THR A CA  1 
ATOM   1100 C C   . THR A 1 172 ? 104.854 101.587 94.059  1.00 114.12 ?  172 THR A C   1 
ATOM   1101 O O   . THR A 1 172 ? 103.704 101.463 94.492  1.00 123.05 ?  172 THR A O   1 
ATOM   1102 C CB  . THR A 1 172 ? 106.719 102.590 95.372  1.00 112.63 ?  172 THR A CB  1 
ATOM   1103 O OG1 . THR A 1 172 ? 107.842 102.305 96.212  1.00 122.03 ?  172 THR A OG1 1 
ATOM   1104 C CG2 . THR A 1 172 ? 105.738 103.467 96.127  1.00 109.65 ?  172 THR A CG2 1 
ATOM   1105 N N   . ALA A 1 173 ? 105.106 101.952 92.802  1.00 113.67 ?  173 ALA A N   1 
ATOM   1106 C CA  . ALA A 1 173 ? 104.006 102.281 91.904  1.00 126.89 ?  173 ALA A CA  1 
ATOM   1107 C C   . ALA A 1 173 ? 103.072 101.092 91.715  1.00 123.99 ?  173 ALA A C   1 
ATOM   1108 O O   . ALA A 1 173 ? 101.853 101.211 91.901  1.00 127.05 ?  173 ALA A O   1 
ATOM   1109 C CB  . ALA A 1 173 ? 104.556 102.756 90.561  1.00 125.85 ?  173 ALA A CB  1 
ATOM   1110 N N   . VAL A 1 174 ? 103.628 99.931  91.371  1.00 108.07 ?  174 VAL A N   1 
ATOM   1111 C CA  . VAL A 1 174 ? 102.797 98.769  91.075  1.00 114.81 ?  174 VAL A CA  1 
ATOM   1112 C C   . VAL A 1 174 ? 102.047 98.312  92.321  1.00 118.63 ?  174 VAL A C   1 
ATOM   1113 O O   . VAL A 1 174 ? 100.843 98.035  92.270  1.00 126.61 ?  174 VAL A O   1 
ATOM   1114 C CB  . VAL A 1 174 ? 103.654 97.638  90.481  1.00 113.59 ?  174 VAL A CB  1 
ATOM   1115 C CG1 . VAL A 1 174 ? 102.889 96.327  90.488  1.00 112.21 ?  174 VAL A CG1 1 
ATOM   1116 C CG2 . VAL A 1 174 ? 104.082 98.001  89.074  1.00 113.05 ?  174 VAL A CG2 1 
ATOM   1117 N N   . SER A 1 175 ? 102.743 98.229  93.458  1.00 102.43 ?  175 SER A N   1 
ATOM   1118 C CA  . SER A 1 175 ? 102.118 97.745  94.682  1.00 111.42 ?  175 SER A CA  1 
ATOM   1119 C C   . SER A 1 175 ? 101.035 98.699  95.165  1.00 114.58 ?  175 SER A C   1 
ATOM   1120 O O   . SER A 1 175 ? 99.971  98.262  95.613  1.00 107.56 ?  175 SER A O   1 
ATOM   1121 C CB  . SER A 1 175 ? 103.175 97.539  95.764  1.00 111.76 ?  175 SER A CB  1 
ATOM   1122 O OG  . SER A 1 175 ? 103.781 98.767  96.118  1.00 120.38 ?  175 SER A OG  1 
ATOM   1123 N N   . GLY A 1 176 ? 101.284 100.008 95.091  1.00 118.07 ?  176 GLY A N   1 
ATOM   1124 C CA  . GLY A 1 176 ? 100.266 100.960 95.493  1.00 113.84 ?  176 GLY A CA  1 
ATOM   1125 C C   . GLY A 1 176 ? 99.050  100.919 94.590  1.00 122.61 ?  176 GLY A C   1 
ATOM   1126 O O   . GLY A 1 176 ? 97.911  100.946 95.067  1.00 130.36 ?  176 GLY A O   1 
ATOM   1127 N N   . THR A 1 177 ? 99.271  100.838 93.275  1.00 123.41 ?  177 THR A N   1 
ATOM   1128 C CA  . THR A 1 177 ? 98.147  100.748 92.351  1.00 120.44 ?  177 THR A CA  1 
ATOM   1129 C C   . THR A 1 177 ? 97.334  99.487  92.601  1.00 118.94 ?  177 THR A C   1 
ATOM   1130 O O   . THR A 1 177 ? 96.098  99.526  92.602  1.00 130.76 ?  177 THR A O   1 
ATOM   1131 C CB  . THR A 1 177 ? 98.648  100.789 90.908  1.00 124.35 ?  177 THR A CB  1 
ATOM   1132 O OG1 . THR A 1 177 ? 99.208  102.079 90.632  1.00 131.34 ?  177 THR A OG1 1 
ATOM   1133 C CG2 . THR A 1 177 ? 97.510  100.523 89.937  1.00 122.57 ?  177 THR A CG2 1 
ATOM   1134 N N   . CYS A 1 178 ? 98.007  98.359  92.833  1.00 113.47 ?  178 CYS A N   1 
ATOM   1135 C CA  . CYS A 1 178 ? 97.287  97.120  93.103  1.00 123.24 ?  178 CYS A CA  1 
ATOM   1136 C C   . CYS A 1 178 ? 96.548  97.171  94.435  1.00 126.11 ?  178 CYS A C   1 
ATOM   1137 O O   . CYS A 1 178 ? 95.418  96.679  94.529  1.00 126.92 ?  178 CYS A O   1 
ATOM   1138 C CB  . CYS A 1 178 ? 98.251  95.938  93.067  1.00 121.74 ?  178 CYS A CB  1 
ATOM   1139 S SG  . CYS A 1 178 ? 98.823  95.495  91.412  1.00 138.02 ?  178 CYS A SG  1 
ATOM   1140 N N   . ALA A 1 179 ? 97.156  97.757  95.468  1.00 116.53 ?  179 ALA A N   1 
ATOM   1141 C CA  . ALA A 1 179 ? 96.471  97.891  96.748  1.00 116.08 ?  179 ALA A CA  1 
ATOM   1142 C C   . ALA A 1 179 ? 95.245  98.781  96.619  1.00 109.10 ?  179 ALA A C   1 
ATOM   1143 O O   . ALA A 1 179 ? 94.253  98.592  97.331  1.00 113.66 ?  179 ALA A O   1 
ATOM   1144 C CB  . ALA A 1 179 ? 97.426  98.444  97.804  1.00 113.45 ?  179 ALA A CB  1 
ATOM   1145 N N   . ALA A 1 180 ? 95.295  99.761  95.715  1.00 120.27 ?  180 ALA A N   1 
ATOM   1146 C CA  . ALA A 1 180 ? 94.104  100.556 95.439  1.00 127.82 ?  180 ALA A CA  1 
ATOM   1147 C C   . ALA A 1 180 ? 93.009  99.718  94.796  1.00 120.18 ?  180 ALA A C   1 
ATOM   1148 O O   . ALA A 1 180 ? 91.836  100.105 94.822  1.00 118.86 ?  180 ALA A O   1 
ATOM   1149 C CB  . ALA A 1 180 ? 94.456  101.744 94.545  1.00 123.63 ?  180 ALA A CB  1 
ATOM   1150 N N   . PHE A 1 181 ? 93.367  98.574  94.213  1.00 112.47 ?  181 PHE A N   1 
ATOM   1151 C CA  . PHE A 1 181 ? 92.429  97.715  93.503  1.00 116.05 ?  181 PHE A CA  1 
ATOM   1152 C C   . PHE A 1 181 ? 92.247  96.365  94.191  1.00 123.95 ?  181 PHE A C   1 
ATOM   1153 O O   . PHE A 1 181 ? 91.827  95.395  93.556  1.00 132.99 ?  181 PHE A O   1 
ATOM   1154 C CB  . PHE A 1 181 ? 92.884  97.503  92.060  1.00 112.63 ?  181 PHE A CB  1 
ATOM   1155 C CG  . PHE A 1 181 ? 92.640  98.680  91.159  1.00 115.77 ?  181 PHE A CG  1 
ATOM   1156 C CD1 . PHE A 1 181 ? 92.866  98.575  89.799  1.00 119.12 ?  181 PHE A CD1 1 
ATOM   1157 C CD2 . PHE A 1 181 ? 92.172  99.879  91.662  1.00 124.33 ?  181 PHE A CD2 1 
ATOM   1158 C CE1 . PHE A 1 181 ? 92.643  99.646  88.962  1.00 125.93 ?  181 PHE A CE1 1 
ATOM   1159 C CE2 . PHE A 1 181 ? 91.946  100.954 90.829  1.00 128.51 ?  181 PHE A CE2 1 
ATOM   1160 C CZ  . PHE A 1 181 ? 92.181  100.837 89.478  1.00 127.20 ?  181 PHE A CZ  1 
ATOM   1161 N N   . ALA A 1 182 ? 92.566  96.281  95.478  1.00 115.62 ?  182 ALA A N   1 
ATOM   1162 C CA  . ALA A 1 182 ? 92.490  95.003  96.171  1.00 116.17 ?  182 ALA A CA  1 
ATOM   1163 C C   . ALA A 1 182 ? 91.039  94.542  96.283  1.00 110.41 ?  182 ALA A C   1 
ATOM   1164 O O   . ALA A 1 182 ? 90.149  95.348  96.569  1.00 102.20 ?  182 ALA A O   1 
ATOM   1165 C CB  . ALA A 1 182 ? 93.114  95.107  97.559  1.00 114.67 ?  182 ALA A CB  1 
ATOM   1166 N N   . PRO A 1 183 ? 90.767  93.256  96.058  1.00 116.87 ?  183 PRO A N   1 
ATOM   1167 C CA  . PRO A 1 183 ? 89.388  92.764  96.149  1.00 121.50 ?  183 PRO A CA  1 
ATOM   1168 C C   . PRO A 1 183 ? 89.002  92.307  97.547  1.00 119.57 ?  183 PRO A C   1 
ATOM   1169 O O   . PRO A 1 183 ? 87.813  92.191  97.858  1.00 121.20 ?  183 PRO A O   1 
ATOM   1170 C CB  . PRO A 1 183 ? 89.382  91.597  95.159  1.00 121.78 ?  183 PRO A CB  1 
ATOM   1171 C CG  . PRO A 1 183 ? 90.768  91.056  95.250  1.00 123.31 ?  183 PRO A CG  1 
ATOM   1172 C CD  . PRO A 1 183 ? 91.684  92.226  95.542  1.00 116.20 ?  183 PRO A CD  1 
ATOM   1173 N N   . ASN A 1 184 ? 89.990  92.040  98.398  1.00 129.49 ?  184 ASN A N   1 
ATOM   1174 C CA  . ASN A 1 184 ? 89.725  91.617  99.765  1.00 127.22 ?  184 ASN A CA  1 
ATOM   1175 C C   . ASN A 1 184 ? 90.886  92.047  100.650 1.00 134.90 ?  184 ASN A C   1 
ATOM   1176 O O   . ASN A 1 184 ? 91.965  92.398  100.170 1.00 145.89 ?  184 ASN A O   1 
ATOM   1177 C CB  . ASN A 1 184 ? 89.493  90.107  99.851  1.00 122.40 ?  184 ASN A CB  1 
ATOM   1178 C CG  . ASN A 1 184 ? 90.658  89.310  99.319  1.00 130.85 ?  184 ASN A CG  1 
ATOM   1179 O OD1 . ASN A 1 184 ? 91.403  89.779  98.461  1.00 135.07 ?  184 ASN A OD1 1 
ATOM   1180 N ND2 . ASN A 1 184 ? 90.823  88.094  99.824  1.00 133.52 ?  184 ASN A ND2 1 
ATOM   1181 N N   . PHE A 1 185 ? 90.646  92.016  101.957 1.00 112.21 ?  185 PHE A N   1 
ATOM   1182 C CA  . PHE A 1 185 ? 91.562  92.560  102.953 1.00 118.87 ?  185 PHE A CA  1 
ATOM   1183 C C   . PHE A 1 185 ? 92.951  91.922  102.932 1.00 117.95 ?  185 PHE A C   1 
ATOM   1184 O O   . PHE A 1 185 ? 93.945  92.652  103.035 1.00 119.22 ?  185 PHE A O   1 
ATOM   1185 C CB  . PHE A 1 185 ? 90.950  92.437  104.350 1.00 119.09 ?  185 PHE A CB  1 
ATOM   1186 C CG  . PHE A 1 185 ? 91.678  93.220  105.402 1.00 115.46 ?  185 PHE A CG  1 
ATOM   1187 C CD1 . PHE A 1 185 ? 91.790  94.593  105.305 1.00 111.24 ?  185 PHE A CD1 1 
ATOM   1188 C CD2 . PHE A 1 185 ? 92.239  92.585  106.492 1.00 116.51 ?  185 PHE A CD2 1 
ATOM   1189 C CE1 . PHE A 1 185 ? 92.453  95.316  106.270 1.00 106.65 ?  185 PHE A CE1 1 
ATOM   1190 C CE2 . PHE A 1 185 ? 92.903  93.303  107.462 1.00 116.65 ?  185 PHE A CE2 1 
ATOM   1191 C CZ  . PHE A 1 185 ? 93.009  94.671  107.350 1.00 112.12 ?  185 PHE A CZ  1 
ATOM   1192 N N   . PRO A 1 186 ? 93.087  90.589  102.843 1.00 109.67 ?  186 PRO A N   1 
ATOM   1193 C CA  . PRO A 1 186 ? 94.444  90.012  102.825 1.00 117.70 ?  186 PRO A CA  1 
ATOM   1194 C C   . PRO A 1 186 ? 95.315  90.510  101.682 1.00 117.60 ?  186 PRO A C   1 
ATOM   1195 O O   . PRO A 1 186 ? 96.510  90.770  101.883 1.00 114.15 ?  186 PRO A O   1 
ATOM   1196 C CB  . PRO A 1 186 ? 94.171  88.508  102.712 1.00 118.10 ?  186 PRO A CB  1 
ATOM   1197 C CG  . PRO A 1 186 ? 92.854  88.330  103.349 1.00 118.15 ?  186 PRO A CG  1 
ATOM   1198 C CD  . PRO A 1 186 ? 92.063  89.532  102.935 1.00 107.22 ?  186 PRO A CD  1 
ATOM   1199 N N   . ILE A 1 187 ? 94.746  90.660  100.486 1.00 113.92 ?  187 ILE A N   1 
ATOM   1200 C CA  . ILE A 1 187 ? 95.525  91.152  99.354  1.00 119.17 ?  187 ILE A CA  1 
ATOM   1201 C C   . ILE A 1 187 ? 95.945  92.595  99.589  1.00 121.67 ?  187 ILE A C   1 
ATOM   1202 O O   . ILE A 1 187 ? 97.083  92.984  99.293  1.00 128.27 ?  187 ILE A O   1 
ATOM   1203 C CB  . ILE A 1 187 ? 94.727  90.990  98.048  1.00 112.18 ?  187 ILE A CB  1 
ATOM   1204 C CG1 . ILE A 1 187 ? 94.673  89.517  97.644  1.00 111.23 ?  187 ILE A CG1 1 
ATOM   1205 C CG2 . ILE A 1 187 ? 95.336  91.823  96.938  1.00 116.44 ?  187 ILE A CG2 1 
ATOM   1206 C CD1 . ILE A 1 187 ? 93.935  89.265  96.355  1.00 117.41 ?  187 ILE A CD1 1 
ATOM   1207 N N   . TYR A 1 188 ? 95.038  93.408  100.134 1.00 96.56  ?  188 TYR A N   1 
ATOM   1208 C CA  . TYR A 1 188 ? 95.386  94.786  100.462 1.00 105.70 ?  188 TYR A CA  1 
ATOM   1209 C C   . TYR A 1 188 ? 96.517  94.837  101.479 1.00 118.19 ?  188 TYR A C   1 
ATOM   1210 O O   . TYR A 1 188 ? 97.440  95.646  101.347 1.00 118.74 ?  188 TYR A O   1 
ATOM   1211 C CB  . TYR A 1 188 ? 94.157  95.528  100.986 1.00 86.29  ?  188 TYR A CB  1 
ATOM   1212 C CG  . TYR A 1 188 ? 94.471  96.839  101.670 1.00 99.99  ?  188 TYR A CG  1 
ATOM   1213 C CD1 . TYR A 1 188 ? 94.741  97.981  100.934 1.00 95.23  ?  188 TYR A CD1 1 
ATOM   1214 C CD2 . TYR A 1 188 ? 94.492  96.934  103.053 1.00 111.11 ?  188 TYR A CD2 1 
ATOM   1215 C CE1 . TYR A 1 188 ? 95.025  99.178  101.558 1.00 97.56  ?  188 TYR A CE1 1 
ATOM   1216 C CE2 . TYR A 1 188 ? 94.776  98.125  103.683 1.00 97.29  ?  188 TYR A CE2 1 
ATOM   1217 C CZ  . TYR A 1 188 ? 95.041  99.242  102.932 1.00 92.74  ?  188 TYR A CZ  1 
ATOM   1218 O OH  . TYR A 1 188 ? 95.323  100.430 103.561 1.00 101.28 ?  188 TYR A OH  1 
ATOM   1219 N N   . CYS A 1 189 ? 96.466  93.977  102.499 1.00 116.94 ?  189 CYS A N   1 
ATOM   1220 C CA  . CYS A 1 189 ? 97.527  93.966  103.501 1.00 112.09 ?  189 CYS A CA  1 
ATOM   1221 C C   . CYS A 1 189 ? 98.862  93.557  102.895 1.00 118.46 ?  189 CYS A C   1 
ATOM   1222 O O   . CYS A 1 189 ? 99.893  94.179  103.176 1.00 123.31 ?  189 CYS A O   1 
ATOM   1223 C CB  . CYS A 1 189 ? 97.156  93.034  104.651 1.00 116.98 ?  189 CYS A CB  1 
ATOM   1224 S SG  . CYS A 1 189 ? 95.863  93.675  105.724 1.00 128.05 ?  189 CYS A SG  1 
ATOM   1225 N N   . ALA A 1 190 ? 98.867  92.516  102.060 1.00 110.87 ?  190 ALA A N   1 
ATOM   1226 C CA  . ALA A 1 190 ? 100.118 92.079  101.446 1.00 120.48 ?  190 ALA A CA  1 
ATOM   1227 C C   . ALA A 1 190 ? 100.699 93.161  100.544 1.00 115.82 ?  190 ALA A C   1 
ATOM   1228 O O   . ALA A 1 190 ? 101.909 93.430  100.573 1.00 117.33 ?  190 ALA A O   1 
ATOM   1229 C CB  . ALA A 1 190 ? 99.897  90.787  100.660 1.00 113.05 ?  190 ALA A CB  1 
ATOM   1230 N N   . PHE A 1 191 ? 99.850  93.806  99.746  1.00 106.62 ?  191 PHE A N   1 
ATOM   1231 C CA  . PHE A 1 191 ? 100.336 94.837  98.844  1.00 113.12 ?  191 PHE A CA  1 
ATOM   1232 C C   . PHE A 1 191 ? 100.776 96.090  99.586  1.00 116.99 ?  191 PHE A C   1 
ATOM   1233 O O   . PHE A 1 191 ? 101.728 96.747  99.154  1.00 125.95 ?  191 PHE A O   1 
ATOM   1234 C CB  . PHE A 1 191 ? 99.259  95.160  97.812  1.00 106.86 ?  191 PHE A CB  1 
ATOM   1235 C CG  . PHE A 1 191 ? 99.242  94.205  96.656  1.00 106.08 ?  191 PHE A CG  1 
ATOM   1236 C CD1 . PHE A 1 191 ? 100.375 93.482  96.330  1.00 108.16 ?  191 PHE A CD1 1 
ATOM   1237 C CD2 . PHE A 1 191 ? 98.088  93.992  95.928  1.00 108.87 ?  191 PHE A CD2 1 
ATOM   1238 C CE1 . PHE A 1 191 ? 100.367 92.591  95.280  1.00 114.49 ?  191 PHE A CE1 1 
ATOM   1239 C CE2 . PHE A 1 191 ? 98.073  93.096  94.878  1.00 110.31 ?  191 PHE A CE2 1 
ATOM   1240 C CZ  . PHE A 1 191 ? 99.215  92.398  94.553  1.00 115.95 ?  191 PHE A CZ  1 
ATOM   1241 N N   . ARG A 1 192 ? 100.143 96.414  100.713 1.00 93.85  ?  192 ARG A N   1 
ATOM   1242 C CA  . ARG A 1 192 ? 100.643 97.502  101.541 1.00 104.17 ?  192 ARG A CA  1 
ATOM   1243 C C   . ARG A 1 192 ? 101.967 97.147  102.206 1.00 113.86 ?  192 ARG A C   1 
ATOM   1244 O O   . ARG A 1 192 ? 102.813 98.027  102.388 1.00 120.30 ?  192 ARG A O   1 
ATOM   1245 C CB  . ARG A 1 192 ? 99.607  97.885  102.594 1.00 108.80 ?  192 ARG A CB  1 
ATOM   1246 C CG  . ARG A 1 192 ? 98.544  98.830  102.078 1.00 105.62 ?  192 ARG A CG  1 
ATOM   1247 C CD  . ARG A 1 192 ? 99.027  100.265 102.117 1.00 98.95  ?  192 ARG A CD  1 
ATOM   1248 N NE  . ARG A 1 192 ? 99.149  100.756 103.483 1.00 98.88  ?  192 ARG A NE  1 
ATOM   1249 C CZ  . ARG A 1 192 ? 99.595  101.960 103.807 1.00 103.52 ?  192 ARG A CZ  1 
ATOM   1250 N NH1 . ARG A 1 192 ? 99.962  102.831 102.883 1.00 110.73 1  192 ARG A NH1 1 
ATOM   1251 N NH2 . ARG A 1 192 ? 99.673  102.300 105.089 1.00 104.78 ?  192 ARG A NH2 1 
ATOM   1252 N N   . LEU A 1 193 ? 102.171 95.881  102.574 1.00 104.63 ?  193 LEU A N   1 
ATOM   1253 C CA  . LEU A 1 193 ? 103.474 95.474  103.096 1.00 107.56 ?  193 LEU A CA  1 
ATOM   1254 C C   . LEU A 1 193 ? 104.555 95.644  102.035 1.00 111.91 ?  193 LEU A C   1 
ATOM   1255 O O   . LEU A 1 193 ? 105.665 96.110  102.324 1.00 99.60  ?  193 LEU A O   1 
ATOM   1256 C CB  . LEU A 1 193 ? 103.411 94.029  103.598 1.00 101.29 ?  193 LEU A CB  1 
ATOM   1257 C CG  . LEU A 1 193 ? 104.697 93.233  103.848 1.00 106.02 ?  193 LEU A CG  1 
ATOM   1258 C CD1 . LEU A 1 193 ? 104.441 92.189  104.912 1.00 110.33 ?  193 LEU A CD1 1 
ATOM   1259 C CD2 . LEU A 1 193 ? 105.201 92.542  102.591 1.00 111.42 ?  193 LEU A CD2 1 
ATOM   1260 N N   . LEU A 1 194 ? 104.245 95.263  100.794 1.00 119.48 ?  194 LEU A N   1 
ATOM   1261 C CA  . LEU A 1 194 ? 105.184 95.504  99.701  1.00 110.87 ?  194 LEU A CA  1 
ATOM   1262 C C   . LEU A 1 194 ? 105.433 96.993  99.495  1.00 116.94 ?  194 LEU A C   1 
ATOM   1263 O O   . LEU A 1 194 ? 106.573 97.403  99.237  1.00 129.77 ?  194 LEU A O   1 
ATOM   1264 C CB  . LEU A 1 194 ? 104.670 94.871  98.411  1.00 101.44 ?  194 LEU A CB  1 
ATOM   1265 C CG  . LEU A 1 194 ? 104.603 93.346  98.424  1.00 110.55 ?  194 LEU A CG  1 
ATOM   1266 C CD1 . LEU A 1 194 ? 103.923 92.836  97.170  1.00 116.81 ?  194 LEU A CD1 1 
ATOM   1267 C CD2 . LEU A 1 194 ? 105.994 92.761  98.561  1.00 110.67 ?  194 LEU A CD2 1 
ATOM   1268 N N   . SER A 1 195 ? 104.382 97.810  99.597  1.00 98.28  ?  195 SER A N   1 
ATOM   1269 C CA  . SER A 1 195 ? 104.550 99.255  99.502  1.00 101.80 ?  195 SER A CA  1 
ATOM   1270 C C   . SER A 1 195 ? 105.488 99.769  100.583 1.00 105.32 ?  195 SER A C   1 
ATOM   1271 O O   . SER A 1 195 ? 106.353 100.609 100.316 1.00 116.74 ?  195 SER A O   1 
ATOM   1272 C CB  . SER A 1 195 ? 103.193 99.946  99.603  1.00 104.42 ?  195 SER A CB  1 
ATOM   1273 O OG  . SER A 1 195 ? 103.190 101.171 98.892  1.00 111.03 ?  195 SER A OG  1 
ATOM   1274 N N   . GLY A 1 196 ? 105.334 99.273  101.809 1.00 96.71  ?  196 GLY A N   1 
ATOM   1275 C CA  . GLY A 1 196 ? 106.231 99.669  102.878 1.00 106.24 ?  196 GLY A CA  1 
ATOM   1276 C C   . GLY A 1 196 ? 107.669 99.268  102.625 1.00 122.69 ?  196 GLY A C   1 
ATOM   1277 O O   . GLY A 1 196 ? 108.586 100.060 102.861 1.00 127.88 ?  196 GLY A O   1 
ATOM   1278 N N   . MET A 1 197 ? 107.887 98.045  102.138 1.00 125.07 ?  197 MET A N   1 
ATOM   1279 C CA  . MET A 1 197 ? 109.245 97.615  101.813 1.00 123.87 ?  197 MET A CA  1 
ATOM   1280 C C   . MET A 1 197 ? 109.874 98.527  100.765 1.00 114.46 ?  197 MET A C   1 
ATOM   1281 O O   . MET A 1 197 ? 111.003 99.015  100.939 1.00 109.57 ?  197 MET A O   1 
ATOM   1282 C CB  . MET A 1 197 ? 109.228 96.167  101.325 1.00 118.57 ?  197 MET A CB  1 
ATOM   1283 C CG  . MET A 1 197 ? 110.323 95.822  100.333 1.00 112.85 ?  197 MET A CG  1 
ATOM   1284 S SD  . MET A 1 197 ? 110.068 94.209  99.574  1.00 132.47 ?  197 MET A SD  1 
ATOM   1285 C CE  . MET A 1 197 ? 110.106 93.152  101.014 1.00 117.80 ?  197 MET A CE  1 
ATOM   1286 N N   . ALA A 1 198 ? 109.144 98.790  99.681  1.00 107.02 ?  198 ALA A N   1 
ATOM   1287 C CA  . ALA A 1 198 ? 109.685 99.614  98.608  1.00 108.82 ?  198 ALA A CA  1 
ATOM   1288 C C   . ALA A 1 198 ? 109.936 101.040 99.080  1.00 115.15 ?  198 ALA A C   1 
ATOM   1289 O O   . ALA A 1 198 ? 110.934 101.663 98.703  1.00 124.91 ?  198 ALA A O   1 
ATOM   1290 C CB  . ALA A 1 198 ? 108.739 99.593  97.410  1.00 106.40 ?  198 ALA A CB  1 
ATOM   1291 N N   . LEU A 1 199 ? 109.048 101.576 99.920  1.00 110.65 ?  199 LEU A N   1 
ATOM   1292 C CA  . LEU A 1 199 ? 109.224 102.946 100.388 1.00 108.70 ?  199 LEU A CA  1 
ATOM   1293 C C   . LEU A 1 199 ? 110.375 103.068 101.373 1.00 110.13 ?  199 LEU A C   1 
ATOM   1294 O O   . LEU A 1 199 ? 111.070 104.088 101.385 1.00 115.68 ?  199 LEU A O   1 
ATOM   1295 C CB  . LEU A 1 199 ? 107.932 103.455 101.014 1.00 106.86 ?  199 LEU A CB  1 
ATOM   1296 C CG  . LEU A 1 199 ? 106.896 103.859 99.972  1.00 114.15 ?  199 LEU A CG  1 
ATOM   1297 C CD1 . LEU A 1 199 ? 105.515 103.690 100.545 1.00 115.36 ?  199 LEU A CD1 1 
ATOM   1298 C CD2 . LEU A 1 199 ? 107.132 105.288 99.518  1.00 101.12 ?  199 LEU A CD2 1 
ATOM   1299 N N   . ALA A 1 200 ? 110.589 102.057 102.215 1.00 106.30 ?  200 ALA A N   1 
ATOM   1300 C CA  . ALA A 1 200 ? 111.766 102.075 103.076 1.00 113.79 ?  200 ALA A CA  1 
ATOM   1301 C C   . ALA A 1 200 ? 113.039 102.032 102.244 1.00 115.93 ?  200 ALA A C   1 
ATOM   1302 O O   . ALA A 1 200 ? 114.013 102.741 102.540 1.00 118.14 ?  200 ALA A O   1 
ATOM   1303 C CB  . ALA A 1 200 ? 111.721 100.908 104.058 1.00 118.61 ?  200 ALA A CB  1 
ATOM   1304 N N   . GLY A 1 201 ? 113.047 101.209 101.193 1.00 123.69 ?  201 GLY A N   1 
ATOM   1305 C CA  . GLY A 1 201 ? 114.163 101.239 100.264 1.00 124.60 ?  201 GLY A CA  1 
ATOM   1306 C C   . GLY A 1 201 ? 114.369 102.604 99.640  1.00 115.85 ?  201 GLY A C   1 
ATOM   1307 O O   . GLY A 1 201 ? 115.508 103.064 99.509  1.00 120.66 ?  201 GLY A O   1 
ATOM   1308 N N   . ILE A 1 202 ? 113.277 103.273 99.265  1.00 106.31 ?  202 ILE A N   1 
ATOM   1309 C CA  . ILE A 1 202 ? 113.366 104.621 98.709  1.00 108.55 ?  202 ILE A CA  1 
ATOM   1310 C C   . ILE A 1 202 ? 113.997 105.570 99.718  1.00 114.93 ?  202 ILE A C   1 
ATOM   1311 O O   . ILE A 1 202 ? 114.904 106.343 99.389  1.00 124.74 ?  202 ILE A O   1 
ATOM   1312 C CB  . ILE A 1 202 ? 111.974 105.120 98.284  1.00 115.38 ?  202 ILE A CB  1 
ATOM   1313 C CG1 . ILE A 1 202 ? 111.564 104.501 96.954  1.00 118.60 ?  202 ILE A CG1 1 
ATOM   1314 C CG2 . ILE A 1 202 ? 111.958 106.637 98.181  1.00 109.20 ?  202 ILE A CG2 1 
ATOM   1315 C CD1 . ILE A 1 202 ? 112.274 105.101 95.784  1.00 118.75 ?  202 ILE A CD1 1 
ATOM   1316 N N   . SER A 1 203 ? 113.521 105.526 100.963 1.00 116.39 ?  203 SER A N   1 
ATOM   1317 C CA  . SER A 1 203 ? 114.002 106.455 101.978 1.00 119.23 ?  203 SER A CA  1 
ATOM   1318 C C   . SER A 1 203 ? 115.486 106.255 102.246 1.00 120.93 ?  203 SER A C   1 
ATOM   1319 O O   . SER A 1 203 ? 116.232 107.228 102.403 1.00 118.12 ?  203 SER A O   1 
ATOM   1320 C CB  . SER A 1 203 ? 113.200 106.289 103.267 1.00 116.03 ?  203 SER A CB  1 
ATOM   1321 O OG  . SER A 1 203 ? 113.440 105.022 103.853 1.00 125.34 ?  203 SER A OG  1 
ATOM   1322 N N   . LEU A 1 204 ? 115.934 105.001 102.306 1.00 126.23 ?  204 LEU A N   1 
ATOM   1323 C CA  . LEU A 1 204 ? 117.348 104.744 102.559 1.00 123.38 ?  204 LEU A CA  1 
ATOM   1324 C C   . LEU A 1 204 ? 118.202 105.168 101.366 1.00 125.53 ?  204 LEU A C   1 
ATOM   1325 O O   . LEU A 1 204 ? 119.210 105.873 101.521 1.00 126.85 ?  204 LEU A O   1 
ATOM   1326 C CB  . LEU A 1 204 ? 117.555 103.263 102.886 1.00 125.50 ?  204 LEU A CB  1 
ATOM   1327 C CG  . LEU A 1 204 ? 118.906 102.604 102.600 1.00 125.72 ?  204 LEU A CG  1 
ATOM   1328 C CD1 . LEU A 1 204 ? 120.026 103.282 103.381 1.00 125.43 ?  204 LEU A CD1 1 
ATOM   1329 C CD2 . LEU A 1 204 ? 118.853 101.119 102.915 1.00 129.27 ?  204 LEU A CD2 1 
ATOM   1330 N N   . ASN A 1 205 ? 117.802 104.758 100.158 1.00 139.68 ?  205 ASN A N   1 
ATOM   1331 C CA  . ASN A 1 205 ? 118.642 104.971 98.987  1.00 136.76 ?  205 ASN A CA  1 
ATOM   1332 C C   . ASN A 1 205 ? 118.684 106.427 98.550  1.00 134.69 ?  205 ASN A C   1 
ATOM   1333 O O   . ASN A 1 205 ? 119.721 106.874 98.055  1.00 136.21 ?  205 ASN A O   1 
ATOM   1334 C CB  . ASN A 1 205 ? 118.165 104.089 97.837  1.00 134.58 ?  205 ASN A CB  1 
ATOM   1335 C CG  . ASN A 1 205 ? 118.829 102.731 97.842  1.00 136.30 ?  205 ASN A CG  1 
ATOM   1336 O OD1 . ASN A 1 205 ? 120.055 102.627 97.849  1.00 134.68 ?  205 ASN A OD1 1 
ATOM   1337 N ND2 . ASN A 1 205 ? 118.023 101.680 97.856  1.00 135.88 ?  205 ASN A ND2 1 
ATOM   1338 N N   . CYS A 1 206 ? 117.593 107.179 98.714  1.00 141.47 ?  206 CYS A N   1 
ATOM   1339 C CA  . CYS A 1 206 ? 117.645 108.606 98.421  1.00 145.84 ?  206 CYS A CA  1 
ATOM   1340 C C   . CYS A 1 206 ? 118.694 109.301 99.276  1.00 151.77 ?  206 CYS A C   1 
ATOM   1341 O O   . CYS A 1 206 ? 119.546 110.028 98.752  1.00 153.64 ?  206 CYS A O   1 
ATOM   1342 C CB  . CYS A 1 206 ? 116.272 109.239 98.643  1.00 143.44 ?  206 CYS A CB  1 
ATOM   1343 S SG  . CYS A 1 206 ? 116.307 111.033 98.852  1.00 147.10 ?  206 CYS A SG  1 
ATOM   1344 N N   . MET A 1 207 ? 118.655 109.084 100.584 1.00 156.21 ?  207 MET A N   1 
ATOM   1345 C CA  . MET A 1 207 ? 119.651 109.690 101.459 1.00 156.08 ?  207 MET A CA  1 
ATOM   1346 C C   . MET A 1 207 ? 121.062 109.243 101.095 1.00 155.61 ?  207 MET A C   1 
ATOM   1347 O O   . MET A 1 207 ? 121.968 110.066 101.013 1.00 158.30 ?  207 MET A O   1 
ATOM   1348 C CB  . MET A 1 207 ? 119.364 109.373 102.924 1.00 159.94 ?  207 MET A CB  1 
ATOM   1349 C CG  . MET A 1 207 ? 118.042 109.925 103.426 1.00 160.53 ?  207 MET A CG  1 
ATOM   1350 S SD  . MET A 1 207 ? 117.856 109.730 105.207 1.00 168.45 ?  207 MET A SD  1 
ATOM   1351 C CE  . MET A 1 207 ? 119.272 110.658 105.789 1.00 156.72 ?  207 MET A CE  1 
ATOM   1352 N N   . THR A 1 208 ? 121.255 107.947 100.871 1.00 145.92 ?  208 THR A N   1 
ATOM   1353 C CA  . THR A 1 208 ? 122.601 107.456 100.587 1.00 146.94 ?  208 THR A CA  1 
ATOM   1354 C C   . THR A 1 208 ? 123.151 108.048 99.292  1.00 146.41 ?  208 THR A C   1 
ATOM   1355 O O   . THR A 1 208 ? 124.271 108.571 99.259  1.00 149.91 ?  208 THR A O   1 
ATOM   1356 C CB  . THR A 1 208 ? 122.602 105.929 100.524 1.00 148.26 ?  208 THR A CB  1 
ATOM   1357 O OG1 . THR A 1 208 ? 122.517 105.398 101.851 1.00 149.93 ?  208 THR A OG1 1 
ATOM   1358 C CG2 . THR A 1 208 ? 123.878 105.430 99.874  1.00 146.41 ?  208 THR A CG2 1 
ATOM   1359 N N   . LEU A 1 209 ? 122.369 107.981 98.211  1.00 139.39 ?  209 LEU A N   1 
ATOM   1360 C CA  . LEU A 1 209 ? 122.832 108.486 96.924  1.00 143.51 ?  209 LEU A CA  1 
ATOM   1361 C C   . LEU A 1 209 ? 122.985 110.000 96.948  1.00 144.93 ?  209 LEU A C   1 
ATOM   1362 O O   . LEU A 1 209 ? 123.802 110.557 96.207  1.00 152.78 ?  209 LEU A O   1 
ATOM   1363 C CB  . LEU A 1 209 ? 121.868 108.051 95.818  1.00 141.36 ?  209 LEU A CB  1 
ATOM   1364 C CG  . LEU A 1 209 ? 122.100 108.521 94.380  1.00 140.54 ?  209 LEU A CG  1 
ATOM   1365 C CD1 . LEU A 1 209 ? 121.701 107.424 93.413  1.00 143.26 ?  209 LEU A CD1 1 
ATOM   1366 C CD2 . LEU A 1 209 ? 121.322 109.790 94.077  1.00 138.62 ?  209 LEU A CD2 1 
ATOM   1367 N N   . ASN A 1 210 ? 122.210 110.687 97.788  1.00 141.78 ?  210 ASN A N   1 
ATOM   1368 C CA  . ASN A 1 210 ? 122.337 112.134 97.874  1.00 146.20 ?  210 ASN A CA  1 
ATOM   1369 C C   . ASN A 1 210 ? 123.600 112.524 98.628  1.00 145.05 ?  210 ASN A C   1 
ATOM   1370 O O   . ASN A 1 210 ? 124.323 113.439 98.220  1.00 137.95 ?  210 ASN A O   1 
ATOM   1371 C CB  . ASN A 1 210 ? 121.100 112.720 98.549  1.00 145.77 ?  210 ASN A CB  1 
ATOM   1372 C CG  . ASN A 1 210 ? 120.400 113.734 97.685  1.00 139.38 ?  210 ASN A CG  1 
ATOM   1373 O OD1 . ASN A 1 210 ? 120.993 114.295 96.770  1.00 134.73 ?  210 ASN A OD1 1 
ATOM   1374 N ND2 . ASN A 1 210 ? 119.128 113.971 97.964  1.00 140.90 ?  210 ASN A ND2 1 
ATOM   1375 N N   . VAL A 1 211 ? 123.885 111.834 99.734  1.00 159.88 ?  211 VAL A N   1 
ATOM   1376 C CA  . VAL A 1 211 ? 125.085 112.135 100.509 1.00 156.87 ?  211 VAL A CA  1 
ATOM   1377 C C   . VAL A 1 211 ? 126.337 111.793 99.712  1.00 160.98 ?  211 VAL A C   1 
ATOM   1378 O O   . VAL A 1 211 ? 127.302 112.567 99.683  1.00 165.34 ?  211 VAL A O   1 
ATOM   1379 C CB  . VAL A 1 211 ? 125.046 111.391 101.857 1.00 156.98 ?  211 VAL A CB  1 
ATOM   1380 C CG1 . VAL A 1 211 ? 126.445 111.233 102.427 1.00 156.79 ?  211 VAL A CG1 1 
ATOM   1381 C CG2 . VAL A 1 211 ? 124.148 112.127 102.837 1.00 155.15 ?  211 VAL A CG2 1 
ATOM   1382 N N   . GLU A 1 212 ? 126.339 110.639 99.040  1.00 166.34 ?  212 GLU A N   1 
ATOM   1383 C CA  . GLU A 1 212 ? 127.548 110.169 98.372  1.00 162.92 ?  212 GLU A CA  1 
ATOM   1384 C C   . GLU A 1 212 ? 127.947 111.030 97.179  1.00 162.94 ?  212 GLU A C   1 
ATOM   1385 O O   . GLU A 1 212 ? 129.098 110.951 96.737  1.00 166.49 ?  212 GLU A O   1 
ATOM   1386 C CB  . GLU A 1 212 ? 127.369 108.716 97.932  1.00 161.99 ?  212 GLU A CB  1 
ATOM   1387 C CG  . GLU A 1 212 ? 127.681 107.711 99.029  1.00 168.69 ?  212 GLU A CG  1 
ATOM   1388 C CD  . GLU A 1 212 ? 127.670 106.279 98.538  1.00 173.11 ?  212 GLU A CD  1 
ATOM   1389 O OE1 . GLU A 1 212 ? 127.352 106.058 97.352  1.00 172.87 ?  212 GLU A OE1 1 
ATOM   1390 O OE2 . GLU A 1 212 ? 127.979 105.372 99.340  1.00 174.79 -1 212 GLU A OE2 1 
ATOM   1391 N N   . TRP A 1 213 ? 127.037 111.841 96.645  1.00 156.39 ?  213 TRP A N   1 
ATOM   1392 C CA  . TRP A 1 213 ? 127.333 112.691 95.498  1.00 158.38 ?  213 TRP A CA  1 
ATOM   1393 C C   . TRP A 1 213 ? 127.630 114.135 95.877  1.00 161.57 ?  213 TRP A C   1 
ATOM   1394 O O   . TRP A 1 213 ? 128.091 114.897 95.024  1.00 165.28 ?  213 TRP A O   1 
ATOM   1395 C CB  . TRP A 1 213 ? 126.172 112.650 94.498  1.00 155.43 ?  213 TRP A CB  1 
ATOM   1396 C CG  . TRP A 1 213 ? 126.387 111.697 93.358  1.00 157.25 ?  213 TRP A CG  1 
ATOM   1397 C CD1 . TRP A 1 213 ? 125.623 110.611 93.046  1.00 158.73 ?  213 TRP A CD1 1 
ATOM   1398 C CD2 . TRP A 1 213 ? 127.415 111.762 92.362  1.00 157.48 ?  213 TRP A CD2 1 
ATOM   1399 N NE1 . TRP A 1 213 ? 126.122 109.985 91.932  1.00 160.46 ?  213 TRP A NE1 1 
ATOM   1400 C CE2 . TRP A 1 213 ? 127.221 110.673 91.491  1.00 161.25 ?  213 TRP A CE2 1 
ATOM   1401 C CE3 . TRP A 1 213 ? 128.485 112.630 92.127  1.00 158.86 ?  213 TRP A CE3 1 
ATOM   1402 C CZ2 . TRP A 1 213 ? 128.055 110.430 90.403  1.00 160.17 ?  213 TRP A CZ2 1 
ATOM   1403 C CZ3 . TRP A 1 213 ? 129.312 112.385 91.046  1.00 157.94 ?  213 TRP A CZ3 1 
ATOM   1404 C CH2 . TRP A 1 213 ? 129.092 111.295 90.199  1.00 155.73 ?  213 TRP A CH2 1 
ATOM   1405 N N   . MET A 1 214 ? 127.388 114.530 97.126  1.00 165.09 ?  214 MET A N   1 
ATOM   1406 C CA  . MET A 1 214 ? 127.615 115.897 97.567  1.00 165.33 ?  214 MET A CA  1 
ATOM   1407 C C   . MET A 1 214 ? 128.894 115.991 98.390  1.00 165.95 ?  214 MET A C   1 
ATOM   1408 O O   . MET A 1 214 ? 129.296 115.017 99.034  1.00 166.07 ?  214 MET A O   1 
ATOM   1409 C CB  . MET A 1 214 ? 126.439 116.415 98.407  1.00 161.75 ?  214 MET A CB  1 
ATOM   1410 C CG  . MET A 1 214 ? 125.098 116.403 97.695  1.00 163.98 ?  214 MET A CG  1 
ATOM   1411 S SD  . MET A 1 214 ? 124.680 117.974 96.920  1.00 164.75 ?  214 MET A SD  1 
ATOM   1412 C CE  . MET A 1 214 ? 124.604 119.045 98.349  1.00 164.31 ?  214 MET A CE  1 
ATOM   1413 N N   . PRO A 1 215 ? 129.558 117.146 98.384  1.00 178.12 ?  215 PRO A N   1 
ATOM   1414 C CA  . PRO A 1 215 ? 130.730 117.328 99.246  1.00 179.31 ?  215 PRO A CA  1 
ATOM   1415 C C   . PRO A 1 215 ? 130.347 117.243 100.715 1.00 180.49 ?  215 PRO A C   1 
ATOM   1416 O O   . PRO A 1 215 ? 129.193 117.448 101.097 1.00 180.90 ?  215 PRO A O   1 
ATOM   1417 C CB  . PRO A 1 215 ? 131.228 118.731 98.881  1.00 177.37 ?  215 PRO A CB  1 
ATOM   1418 C CG  . PRO A 1 215 ? 130.710 118.974 97.510  1.00 175.28 ?  215 PRO A CG  1 
ATOM   1419 C CD  . PRO A 1 215 ? 129.396 118.253 97.426  1.00 175.40 ?  215 PRO A CD  1 
ATOM   1420 N N   . ILE A 1 216 ? 131.342 116.926 101.550 1.00 181.86 ?  216 ILE A N   1 
ATOM   1421 C CA  . ILE A 1 216 ? 131.075 116.724 102.969 1.00 183.11 ?  216 ILE A CA  1 
ATOM   1422 C C   . ILE A 1 216 ? 130.595 118.002 103.648 1.00 184.41 ?  216 ILE A C   1 
ATOM   1423 O O   . ILE A 1 216 ? 129.721 117.939 104.522 1.00 185.84 ?  216 ILE A O   1 
ATOM   1424 C CB  . ILE A 1 216 ? 132.315 116.145 103.684 1.00 181.67 ?  216 ILE A CB  1 
ATOM   1425 C CG1 . ILE A 1 216 ? 131.918 115.543 105.033 1.00 183.10 ?  216 ILE A CG1 1 
ATOM   1426 C CG2 . ILE A 1 216 ? 133.393 117.201 103.883 1.00 180.18 ?  216 ILE A CG2 1 
ATOM   1427 C CD1 . ILE A 1 216 ? 132.787 114.383 105.462 1.00 181.35 ?  216 ILE A CD1 1 
ATOM   1428 N N   . HIS A 1 217 ? 131.107 119.167 103.246 1.00 184.72 ?  217 HIS A N   1 
ATOM   1429 C CA  . HIS A 1 217 ? 130.751 120.417 103.904 1.00 184.62 ?  217 HIS A CA  1 
ATOM   1430 C C   . HIS A 1 217 ? 129.283 120.778 103.733 1.00 187.57 ?  217 HIS A C   1 
ATOM   1431 O O   . HIS A 1 217 ? 128.791 121.656 104.450 1.00 186.31 ?  217 HIS A O   1 
ATOM   1432 C CB  . HIS A 1 217 ? 131.630 121.558 103.385 1.00 183.29 ?  217 HIS A CB  1 
ATOM   1433 C CG  . HIS A 1 217 ? 131.217 122.082 102.045 1.00 185.30 ?  217 HIS A CG  1 
ATOM   1434 N ND1 . HIS A 1 217 ? 131.431 121.386 100.875 1.00 186.37 ?  217 HIS A ND1 1 
ATOM   1435 C CD2 . HIS A 1 217 ? 130.608 123.238 101.689 1.00 184.49 ?  217 HIS A CD2 1 
ATOM   1436 C CE1 . HIS A 1 217 ? 130.969 122.089 99.856  1.00 186.41 ?  217 HIS A CE1 1 
ATOM   1437 N NE2 . HIS A 1 217 ? 130.465 123.217 100.323 1.00 185.77 ?  217 HIS A NE2 1 
ATOM   1438 N N   . THR A 1 218 ? 128.575 120.129 102.807 1.00 185.84 ?  218 THR A N   1 
ATOM   1439 C CA  . THR A 1 218 ? 127.138 120.315 102.647 1.00 182.42 ?  218 THR A CA  1 
ATOM   1440 C C   . THR A 1 218 ? 126.365 119.019 102.866 1.00 180.94 ?  218 THR A C   1 
ATOM   1441 O O   . THR A 1 218 ? 125.176 118.953 102.542 1.00 185.37 ?  218 THR A O   1 
ATOM   1442 C CB  . THR A 1 218 ? 126.818 120.890 101.266 1.00 182.84 ?  218 THR A CB  1 
ATOM   1443 O OG1 . THR A 1 218 ? 127.494 120.126 100.259 1.00 184.39 ?  218 THR A OG1 1 
ATOM   1444 C CG2 . THR A 1 218 ? 127.255 122.343 101.177 1.00 180.51 ?  218 THR A CG2 1 
ATOM   1445 N N   . ARG A 1 219 ? 127.014 117.981 103.401 1.00 169.62 ?  219 ARG A N   1 
ATOM   1446 C CA  . ARG A 1 219 ? 126.304 116.725 103.624 1.00 173.34 ?  219 ARG A CA  1 
ATOM   1447 C C   . ARG A 1 219 ? 125.239 116.861 104.706 1.00 177.52 ?  219 ARG A C   1 
ATOM   1448 O O   . ARG A 1 219 ? 124.074 116.512 104.477 1.00 179.17 ?  219 ARG A O   1 
ATOM   1449 C CB  . ARG A 1 219 ? 127.288 115.613 103.987 1.00 173.38 ?  219 ARG A CB  1 
ATOM   1450 C CG  . ARG A 1 219 ? 127.914 114.930 102.783 1.00 175.77 ?  219 ARG A CG  1 
ATOM   1451 C CD  . ARG A 1 219 ? 128.882 113.835 103.201 1.00 176.80 ?  219 ARG A CD  1 
ATOM   1452 N NE  . ARG A 1 219 ? 129.468 113.162 102.048 1.00 176.75 ?  219 ARG A NE  1 
ATOM   1453 C CZ  . ARG A 1 219 ? 130.336 112.162 102.123 1.00 175.19 ?  219 ARG A CZ  1 
ATOM   1454 N NH1 . ARG A 1 219 ? 130.743 111.687 103.289 1.00 176.77 1  219 ARG A NH1 1 
ATOM   1455 N NH2 . ARG A 1 219 ? 130.807 111.626 101.001 1.00 173.52 ?  219 ARG A NH2 1 
ATOM   1456 N N   . ALA A 1 220 ? 125.610 117.398 105.871 1.00 174.96 ?  220 ALA A N   1 
ATOM   1457 C CA  . ALA A 1 220 ? 124.675 117.465 106.990 1.00 173.49 ?  220 ALA A CA  1 
ATOM   1458 C C   . ALA A 1 220 ? 123.442 118.279 106.624 1.00 172.49 ?  220 ALA A C   1 
ATOM   1459 O O   . ALA A 1 220 ? 122.309 117.866 106.898 1.00 171.12 ?  220 ALA A O   1 
ATOM   1460 C CB  . ALA A 1 220 ? 125.367 118.056 108.218 1.00 170.67 ?  220 ALA A CB  1 
ATOM   1461 N N   . CYS A 1 221 ? 123.648 119.431 105.978 1.00 174.45 ?  221 CYS A N   1 
ATOM   1462 C CA  . CYS A 1 221 ? 122.522 120.250 105.540 1.00 170.76 ?  221 CYS A CA  1 
ATOM   1463 C C   . CYS A 1 221 ? 121.547 119.436 104.703 1.00 170.30 ?  221 CYS A C   1 
ATOM   1464 O O   . CYS A 1 221 ? 120.326 119.560 104.866 1.00 175.88 ?  221 CYS A O   1 
ATOM   1465 C CB  . CYS A 1 221 ? 123.025 121.457 104.750 1.00 172.49 ?  221 CYS A CB  1 
ATOM   1466 S SG  . CYS A 1 221 ? 124.343 122.386 105.565 1.00 184.70 ?  221 CYS A SG  1 
ATOM   1467 N N   . VAL A 1 222 ? 122.069 118.563 103.834 1.00 148.45 ?  222 VAL A N   1 
ATOM   1468 C CA  . VAL A 1 222 ? 121.197 117.729 103.013 1.00 148.41 ?  222 VAL A CA  1 
ATOM   1469 C C   . VAL A 1 222 ? 120.232 116.954 103.895 1.00 152.56 ?  222 VAL A C   1 
ATOM   1470 O O   . VAL A 1 222 ? 119.015 116.966 103.668 1.00 154.60 ?  222 VAL A O   1 
ATOM   1471 C CB  . VAL A 1 222 ? 122.032 116.788 102.126 1.00 151.70 ?  222 VAL A CB  1 
ATOM   1472 C CG1 . VAL A 1 222 ? 121.189 115.613 101.655 1.00 151.49 ?  222 VAL A CG1 1 
ATOM   1473 C CG2 . VAL A 1 222 ? 122.595 117.548 100.941 1.00 149.76 ?  222 VAL A CG2 1 
ATOM   1474 N N   . GLY A 1 223 ? 120.752 116.322 104.950 1.00 155.60 ?  223 GLY A N   1 
ATOM   1475 C CA  . GLY A 1 223 ? 119.881 115.605 105.864 1.00 154.45 ?  223 GLY A CA  1 
ATOM   1476 C C   . GLY A 1 223 ? 118.779 116.491 106.406 1.00 156.60 ?  223 GLY A C   1 
ATOM   1477 O O   . GLY A 1 223 ? 117.604 116.111 106.393 1.00 159.44 ?  223 GLY A O   1 
ATOM   1478 N N   . THR A 1 224 ? 119.134 117.707 106.833 1.00 154.93 ?  224 THR A N   1 
ATOM   1479 C CA  . THR A 1 224 ? 118.119 118.649 107.291 1.00 152.76 ?  224 THR A CA  1 
ATOM   1480 C C   . THR A 1 224 ? 117.049 118.841 106.228 1.00 148.57 ?  224 THR A C   1 
ATOM   1481 O O   . THR A 1 224 ? 115.852 118.682 106.502 1.00 154.19 ?  224 THR A O   1 
ATOM   1482 C CB  . THR A 1 224 ? 118.762 119.987 107.654 1.00 157.39 ?  224 THR A CB  1 
ATOM   1483 O OG1 . THR A 1 224 ? 118.956 120.764 106.466 1.00 160.16 ?  224 THR A OG1 1 
ATOM   1484 C CG2 . THR A 1 224 ? 120.099 119.766 108.342 1.00 153.81 ?  224 THR A CG2 1 
ATOM   1485 N N   . LEU A 1 225 ? 117.469 119.122 104.990 1.00 123.44 ?  225 LEU A N   1 
ATOM   1486 C CA  . LEU A 1 225 ? 116.509 119.280 103.906 1.00 123.44 ?  225 LEU A CA  1 
ATOM   1487 C C   . LEU A 1 225 ? 115.616 118.055 103.802 1.00 132.17 ?  225 LEU A C   1 
ATOM   1488 O O   . LEU A 1 225 ? 114.388 118.180 103.703 1.00 143.58 ?  225 LEU A O   1 
ATOM   1489 C CB  . LEU A 1 225 ? 117.238 119.531 102.587 1.00 131.20 ?  225 LEU A CB  1 
ATOM   1490 C CG  . LEU A 1 225 ? 116.367 119.683 101.341 1.00 129.32 ?  225 LEU A CG  1 
ATOM   1491 C CD1 . LEU A 1 225 ? 115.592 120.986 101.389 1.00 125.79 ?  225 LEU A CD1 1 
ATOM   1492 C CD2 . LEU A 1 225 ? 117.219 119.610 100.085 1.00 135.94 ?  225 LEU A CD2 1 
ATOM   1493 N N   . ILE A 1 226 ? 116.214 116.861 103.889 1.00 127.74 ?  226 ILE A N   1 
ATOM   1494 C CA  . ILE A 1 226 ? 115.424 115.635 103.848 1.00 124.19 ?  226 ILE A CA  1 
ATOM   1495 C C   . ILE A 1 226 ? 114.293 115.712 104.859 1.00 126.05 ?  226 ILE A C   1 
ATOM   1496 O O   . ILE A 1 226 ? 113.112 115.610 104.498 1.00 129.57 ?  226 ILE A O   1 
ATOM   1497 C CB  . ILE A 1 226 ? 116.322 114.410 104.100 1.00 126.58 ?  226 ILE A CB  1 
ATOM   1498 C CG1 . ILE A 1 226 ? 117.387 114.277 103.010 1.00 133.92 ?  226 ILE A CG1 1 
ATOM   1499 C CG2 . ILE A 1 226 ? 115.487 113.148 104.194 1.00 118.22 ?  226 ILE A CG2 1 
ATOM   1500 C CD1 . ILE A 1 226 ? 116.854 114.449 101.630 1.00 129.65 ?  226 ILE A CD1 1 
ATOM   1501 N N   . GLY A 1 227 ? 114.627 116.004 106.119 1.00 133.96 ?  227 GLY A N   1 
ATOM   1502 C CA  . GLY A 1 227 ? 113.596 116.078 107.137 1.00 136.44 ?  227 GLY A CA  1 
ATOM   1503 C C   . GLY A 1 227 ? 112.510 117.066 106.767 1.00 134.95 ?  227 GLY A C   1 
ATOM   1504 O O   . GLY A 1 227 ? 111.319 116.749 106.840 1.00 135.48 ?  227 GLY A O   1 
ATOM   1505 N N   . TYR A 1 228 ? 112.906 118.247 106.290 1.00 138.86 ?  228 TYR A N   1 
ATOM   1506 C CA  . TYR A 1 228 ? 111.911 119.245 105.937 1.00 135.56 ?  228 TYR A CA  1 
ATOM   1507 C C   . TYR A 1 228 ? 111.006 118.745 104.825 1.00 139.83 ?  228 TYR A C   1 
ATOM   1508 O O   . TYR A 1 228 ? 109.782 118.901 104.912 1.00 150.61 ?  228 TYR A O   1 
ATOM   1509 C CB  . TYR A 1 228 ? 112.593 120.550 105.532 1.00 133.86 ?  228 TYR A CB  1 
ATOM   1510 C CG  . TYR A 1 228 ? 112.923 121.425 106.715 1.00 139.31 ?  228 TYR A CG  1 
ATOM   1511 C CD1 . TYR A 1 228 ? 111.925 122.082 107.417 1.00 139.92 ?  228 TYR A CD1 1 
ATOM   1512 C CD2 . TYR A 1 228 ? 114.234 121.575 107.143 1.00 149.06 ?  228 TYR A CD2 1 
ATOM   1513 C CE1 . TYR A 1 228 ? 112.226 122.875 108.506 1.00 142.87 ?  228 TYR A CE1 1 
ATOM   1514 C CE2 . TYR A 1 228 ? 114.544 122.364 108.227 1.00 147.34 ?  228 TYR A CE2 1 
ATOM   1515 C CZ  . TYR A 1 228 ? 113.538 123.011 108.906 1.00 147.28 ?  228 TYR A CZ  1 
ATOM   1516 O OH  . TYR A 1 228 ? 113.850 123.798 109.988 1.00 145.31 ?  228 TYR A OH  1 
ATOM   1517 N N   . VAL A 1 229 ? 111.576 118.094 103.809 1.00 118.79 ?  229 VAL A N   1 
ATOM   1518 C CA  . VAL A 1 229 ? 110.738 117.610 102.722 1.00 118.46 ?  229 VAL A CA  1 
ATOM   1519 C C   . VAL A 1 229 ? 109.814 116.514 103.228 1.00 128.25 ?  229 VAL A C   1 
ATOM   1520 O O   . VAL A 1 229 ? 108.698 116.348 102.721 1.00 134.72 ?  229 VAL A O   1 
ATOM   1521 C CB  . VAL A 1 229 ? 111.610 117.157 101.538 1.00 119.79 ?  229 VAL A CB  1 
ATOM   1522 C CG1 . VAL A 1 229 ? 110.781 116.423 100.499 1.00 119.80 ?  229 VAL A CG1 1 
ATOM   1523 C CG2 . VAL A 1 229 ? 112.276 118.366 100.912 1.00 120.50 ?  229 VAL A CG2 1 
ATOM   1524 N N   . TYR A 1 230 ? 110.234 115.773 104.255 1.00 127.26 ?  230 TYR A N   1 
ATOM   1525 C CA  . TYR A 1 230 ? 109.305 114.843 104.880 1.00 125.89 ?  230 TYR A CA  1 
ATOM   1526 C C   . TYR A 1 230 ? 108.183 115.605 105.573 1.00 125.79 ?  230 TYR A C   1 
ATOM   1527 O O   . TYR A 1 230 ? 107.003 115.286 105.394 1.00 126.19 ?  230 TYR A O   1 
ATOM   1528 C CB  . TYR A 1 230 ? 110.053 113.934 105.860 1.00 125.25 ?  230 TYR A CB  1 
ATOM   1529 C CG  . TYR A 1 230 ? 109.216 112.853 106.517 1.00 126.75 ?  230 TYR A CG  1 
ATOM   1530 C CD1 . TYR A 1 230 ? 109.404 111.517 106.190 1.00 123.36 ?  230 TYR A CD1 1 
ATOM   1531 C CD2 . TYR A 1 230 ? 108.270 113.158 107.488 1.00 133.40 ?  230 TYR A CD2 1 
ATOM   1532 C CE1 . TYR A 1 230 ? 108.656 110.522 106.788 1.00 135.12 ?  230 TYR A CE1 1 
ATOM   1533 C CE2 . TYR A 1 230 ? 107.517 112.171 108.090 1.00 134.26 ?  230 TYR A CE2 1 
ATOM   1534 C CZ  . TYR A 1 230 ? 107.714 110.855 107.738 1.00 137.53 ?  230 TYR A CZ  1 
ATOM   1535 O OH  . TYR A 1 230 ? 106.966 109.869 108.339 1.00 132.53 ?  230 TYR A OH  1 
ATOM   1536 N N   . SER A 1 231 ? 108.536 116.645 106.335 1.00 127.02 ?  231 SER A N   1 
ATOM   1537 C CA  . SER A 1 231 ? 107.533 117.368 107.110 1.00 128.46 ?  231 SER A CA  1 
ATOM   1538 C C   . SER A 1 231 ? 106.482 117.990 106.204 1.00 134.00 ?  231 SER A C   1 
ATOM   1539 O O   . SER A 1 231 ? 105.278 117.793 106.411 1.00 136.30 ?  231 SER A O   1 
ATOM   1540 C CB  . SER A 1 231 ? 108.205 118.438 107.968 1.00 132.23 ?  231 SER A CB  1 
ATOM   1541 O OG  . SER A 1 231 ? 107.276 119.436 108.349 1.00 137.02 ?  231 SER A OG  1 
ATOM   1542 N N   . LEU A 1 232 ? 106.918 118.720 105.174 1.00 122.13 ?  232 LEU A N   1 
ATOM   1543 C CA  . LEU A 1 232 ? 105.979 119.291 104.218 1.00 115.35 ?  232 LEU A CA  1 
ATOM   1544 C C   . LEU A 1 232 ? 105.093 118.227 103.592 1.00 125.78 ?  232 LEU A C   1 
ATOM   1545 O O   . LEU A 1 232 ? 103.942 118.522 103.249 1.00 137.10 ?  232 LEU A O   1 
ATOM   1546 C CB  . LEU A 1 232 ? 106.728 120.049 103.125 1.00 110.55 ?  232 LEU A CB  1 
ATOM   1547 C CG  . LEU A 1 232 ? 107.573 121.232 103.595 1.00 127.78 ?  232 LEU A CG  1 
ATOM   1548 C CD1 . LEU A 1 232 ? 108.533 121.668 102.501 1.00 134.86 ?  232 LEU A CD1 1 
ATOM   1549 C CD2 . LEU A 1 232 ? 106.688 122.385 104.030 1.00 124.34 ?  232 LEU A CD2 1 
ATOM   1550 N N   . GLY A 1 233 ? 105.592 116.994 103.471 1.00 124.03 ?  233 GLY A N   1 
ATOM   1551 C CA  . GLY A 1 233 ? 104.774 115.926 102.929 1.00 125.64 ?  233 GLY A CA  1 
ATOM   1552 C C   . GLY A 1 233 ? 103.469 115.753 103.675 1.00 130.90 ?  233 GLY A C   1 
ATOM   1553 O O   . GLY A 1 233 ? 102.431 115.487 103.061 1.00 130.73 ?  233 GLY A O   1 
ATOM   1554 N N   . GLN A 1 234 ? 103.493 115.936 104.999 1.00 130.12 ?  234 GLN A N   1 
ATOM   1555 C CA  . GLN A 1 234 ? 102.261 115.838 105.773 1.00 123.65 ?  234 GLN A CA  1 
ATOM   1556 C C   . GLN A 1 234 ? 101.208 116.801 105.246 1.00 126.05 ?  234 GLN A C   1 
ATOM   1557 O O   . GLN A 1 234 ? 100.050 116.410 105.048 1.00 125.09 ?  234 GLN A O   1 
ATOM   1558 C CB  . GLN A 1 234 ? 102.545 116.104 107.250 1.00 124.50 ?  234 GLN A CB  1 
ATOM   1559 C CG  . GLN A 1 234 ? 103.631 115.222 107.833 1.00 135.78 ?  234 GLN A CG  1 
ATOM   1560 C CD  . GLN A 1 234 ? 103.751 115.363 109.335 1.00 137.84 ?  234 GLN A CD  1 
ATOM   1561 O OE1 . GLN A 1 234 ? 104.732 114.925 109.935 1.00 136.68 ?  234 GLN A OE1 1 
ATOM   1562 N NE2 . GLN A 1 234 ? 102.751 115.977 109.952 1.00 137.97 ?  234 GLN A NE2 1 
ATOM   1563 N N   . PHE A 1 235 ? 101.600 118.050 104.971 1.00 115.79 ?  235 PHE A N   1 
ATOM   1564 C CA  . PHE A 1 235 ? 100.657 119.003 104.396 1.00 114.91 ?  235 PHE A CA  1 
ATOM   1565 C C   . PHE A 1 235 ? 100.006 118.450 103.140 1.00 117.02 ?  235 PHE A C   1 
ATOM   1566 O O   . PHE A 1 235 ? 98.791  118.592 102.961 1.00 127.71 ?  235 PHE A O   1 
ATOM   1567 C CB  . PHE A 1 235 ? 101.348 120.326 104.078 1.00 113.27 ?  235 PHE A CB  1 
ATOM   1568 C CG  . PHE A 1 235 ? 101.771 121.094 105.287 1.00 109.97 ?  235 PHE A CG  1 
ATOM   1569 C CD1 . PHE A 1 235 ? 100.833 121.554 106.189 1.00 109.14 ?  235 PHE A CD1 1 
ATOM   1570 C CD2 . PHE A 1 235 ? 103.103 121.374 105.513 1.00 120.29 ?  235 PHE A CD2 1 
ATOM   1571 C CE1 . PHE A 1 235 ? 101.217 122.266 107.300 1.00 114.46 ?  235 PHE A CE1 1 
ATOM   1572 C CE2 . PHE A 1 235 ? 103.492 122.088 106.623 1.00 124.79 ?  235 PHE A CE2 1 
ATOM   1573 C CZ  . PHE A 1 235 ? 102.548 122.535 107.517 1.00 117.32 ?  235 PHE A CZ  1 
ATOM   1574 N N   . LEU A 1 236 ? 100.788 117.794 102.279 1.00 103.48 ?  236 LEU A N   1 
ATOM   1575 C CA  . LEU A 1 236 ? 100.217 117.231 101.063 1.00 105.94 ?  236 LEU A CA  1 
ATOM   1576 C C   . LEU A 1 236 ? 99.107  116.246 101.394 1.00 119.03 ?  236 LEU A C   1 
ATOM   1577 O O   . LEU A 1 236 ? 98.022  116.302 100.801 1.00 125.04 ?  236 LEU A O   1 
ATOM   1578 C CB  . LEU A 1 236 ? 101.307 116.559 100.233 1.00 101.21 ?  236 LEU A CB  1 
ATOM   1579 C CG  . LEU A 1 236 ? 100.818 115.867 98.965  1.00 105.56 ?  236 LEU A CG  1 
ATOM   1580 C CD1 . LEU A 1 236 ? 100.186 116.883 98.035  1.00 106.64 ?  236 LEU A CD1 1 
ATOM   1581 C CD2 . LEU A 1 236 ? 101.967 115.161 98.279  1.00 112.06 ?  236 LEU A CD2 1 
ATOM   1582 N N   . LEU A 1 237 ? 99.339  115.368 102.373 1.00 118.51 ?  237 LEU A N   1 
ATOM   1583 C CA  . LEU A 1 237 ? 98.303  114.414 102.749 1.00 115.81 ?  237 LEU A CA  1 
ATOM   1584 C C   . LEU A 1 237 ? 97.078  115.132 103.292 1.00 114.85 ?  237 LEU A C   1 
ATOM   1585 O O   . LEU A 1 237 ? 95.947  114.665 103.121 1.00 114.26 ?  237 LEU A O   1 
ATOM   1586 C CB  . LEU A 1 237 ? 98.840  113.421 103.777 1.00 109.89 ?  237 LEU A CB  1 
ATOM   1587 C CG  . LEU A 1 237 ? 97.869  112.287 104.094 1.00 106.75 ?  237 LEU A CG  1 
ATOM   1588 C CD1 . LEU A 1 237 ? 97.570  111.494 102.838 1.00 114.45 ?  237 LEU A CD1 1 
ATOM   1589 C CD2 . LEU A 1 237 ? 98.425  111.391 105.170 1.00 109.01 ?  237 LEU A CD2 1 
ATOM   1590 N N   . ALA A 1 238 ? 97.282  116.275 103.946 1.00 113.18 ?  238 ALA A N   1 
ATOM   1591 C CA  . ALA A 1 238 ? 96.148  117.056 104.422 1.00 110.95 ?  238 ALA A CA  1 
ATOM   1592 C C   . ALA A 1 238 ? 95.327  117.581 103.255 1.00 111.86 ?  238 ALA A C   1 
ATOM   1593 O O   . ALA A 1 238 ? 94.097  117.659 103.330 1.00 119.83 ?  238 ALA A O   1 
ATOM   1594 C CB  . ALA A 1 238 ? 96.635  118.203 105.302 1.00 117.78 ?  238 ALA A CB  1 
ATOM   1595 N N   . GLY A 1 239 ? 95.996  117.946 102.160 1.00 116.46 ?  239 GLY A N   1 
ATOM   1596 C CA  . GLY A 1 239 ? 95.280  118.522 101.036 1.00 122.08 ?  239 GLY A CA  1 
ATOM   1597 C C   . GLY A 1 239 ? 94.613  117.476 100.166 1.00 122.24 ?  239 GLY A C   1 
ATOM   1598 O O   . GLY A 1 239 ? 93.403  117.533 99.928  1.00 127.12 ?  239 GLY A O   1 
ATOM   1599 N N   . VAL A 1 240 ? 95.389  116.496 99.697  1.00 105.61 ?  240 VAL A N   1 
ATOM   1600 C CA  . VAL A 1 240 ? 94.872  115.517 98.746  1.00 107.93 ?  240 VAL A CA  1 
ATOM   1601 C C   . VAL A 1 240 ? 93.685  114.769 99.337  1.00 120.28 ?  240 VAL A C   1 
ATOM   1602 O O   . VAL A 1 240 ? 92.635  114.635 98.695  1.00 123.55 ?  240 VAL A O   1 
ATOM   1603 C CB  . VAL A 1 240 ? 95.994  114.554 98.318  1.00 100.13 ?  240 VAL A CB  1 
ATOM   1604 C CG1 . VAL A 1 240 ? 95.411  113.287 97.741  1.00 120.96 ?  240 VAL A CG1 1 
ATOM   1605 C CG2 . VAL A 1 240 ? 96.907  115.223 97.312  1.00 109.12 ?  240 VAL A CG2 1 
ATOM   1606 N N   . ALA A 1 241 ? 93.817  114.303 100.581 1.00 126.06 ?  241 ALA A N   1 
ATOM   1607 C CA  . ALA A 1 241 ? 92.732  113.557 101.210 1.00 127.52 ?  241 ALA A CA  1 
ATOM   1608 C C   . ALA A 1 241 ? 91.466  114.393 101.332 1.00 122.96 ?  241 ALA A C   1 
ATOM   1609 O O   . ALA A 1 241 ? 90.367  113.838 101.426 1.00 119.09 ?  241 ALA A O   1 
ATOM   1610 C CB  . ALA A 1 241 ? 93.166  113.050 102.584 1.00 124.57 ?  241 ALA A CB  1 
ATOM   1611 N N   . TYR A 1 242 ? 91.594  115.721 101.343 1.00 119.18 ?  242 TYR A N   1 
ATOM   1612 C CA  . TYR A 1 242 ? 90.402  116.562 101.354 1.00 115.44 ?  242 TYR A CA  1 
ATOM   1613 C C   . TYR A 1 242 ? 89.709  116.538 99.999  1.00 120.17 ?  242 TYR A C   1 
ATOM   1614 O O   . TYR A 1 242 ? 88.478  116.458 99.919  1.00 128.22 ?  242 TYR A O   1 
ATOM   1615 C CB  . TYR A 1 242 ? 90.763  117.993 101.746 1.00 115.25 ?  242 TYR A CB  1 
ATOM   1616 C CG  . TYR A 1 242 ? 89.560  118.895 101.866 1.00 117.59 ?  242 TYR A CG  1 
ATOM   1617 C CD1 . TYR A 1 242 ? 88.387  118.440 102.451 1.00 121.14 ?  242 TYR A CD1 1 
ATOM   1618 C CD2 . TYR A 1 242 ? 89.591  120.197 101.390 1.00 121.78 ?  242 TYR A CD2 1 
ATOM   1619 C CE1 . TYR A 1 242 ? 87.281  119.257 102.563 1.00 124.48 ?  242 TYR A CE1 1 
ATOM   1620 C CE2 . TYR A 1 242 ? 88.489  121.022 101.497 1.00 130.70 ?  242 TYR A CE2 1 
ATOM   1621 C CZ  . TYR A 1 242 ? 87.337  120.546 102.085 1.00 131.60 ?  242 TYR A CZ  1 
ATOM   1622 O OH  . TYR A 1 242 ? 86.235  121.363 102.195 1.00 128.04 ?  242 TYR A OH  1 
ATOM   1623 N N   . ALA A 1 243 ? 90.486  116.611 98.918  1.00 121.68 ?  243 ALA A N   1 
ATOM   1624 C CA  . ALA A 1 243 ? 89.889  116.644 97.588  1.00 127.02 ?  243 ALA A CA  1 
ATOM   1625 C C   . ALA A 1 243 ? 89.414  115.264 97.160  1.00 126.50 ?  243 ALA A C   1 
ATOM   1626 O O   . ALA A 1 243 ? 88.470  115.143 96.371  1.00 135.76 ?  243 ALA A O   1 
ATOM   1627 C CB  . ALA A 1 243 ? 90.885  117.205 96.575  1.00 125.14 ?  243 ALA A CB  1 
ATOM   1628 N N   . VAL A 1 244 ? 90.051  114.215 97.668  1.00 113.30 ?  244 VAL A N   1 
ATOM   1629 C CA  . VAL A 1 244 ? 89.751  112.846 97.261  1.00 114.30 ?  244 VAL A CA  1 
ATOM   1630 C C   . VAL A 1 244 ? 89.419  112.026 98.501  1.00 118.17 ?  244 VAL A C   1 
ATOM   1631 O O   . VAL A 1 244 ? 90.297  111.342 99.047  1.00 127.77 ?  244 VAL A O   1 
ATOM   1632 C CB  . VAL A 1 244 ? 90.925  112.232 96.483  1.00 108.05 ?  244 VAL A CB  1 
ATOM   1633 C CG1 . VAL A 1 244 ? 90.539  110.887 95.930  1.00 118.19 ?  244 VAL A CG1 1 
ATOM   1634 C CG2 . VAL A 1 244 ? 91.350  113.155 95.361  1.00 111.11 ?  244 VAL A CG2 1 
ATOM   1635 N N   . PRO A 1 245 ? 88.176  112.067 98.987  1.00 115.98 ?  245 PRO A N   1 
ATOM   1636 C CA  . PRO A 1 245 ? 87.870  111.352 100.235 1.00 117.63 ?  245 PRO A CA  1 
ATOM   1637 C C   . PRO A 1 245 ? 87.793  109.846 100.067 1.00 118.07 ?  245 PRO A C   1 
ATOM   1638 O O   . PRO A 1 245 ? 88.075  109.112 101.023 1.00 116.50 ?  245 PRO A O   1 
ATOM   1639 C CB  . PRO A 1 245 ? 86.522  111.953 100.651 1.00 122.32 ?  245 PRO A CB  1 
ATOM   1640 C CG  . PRO A 1 245 ? 85.891  112.352 99.364  1.00 119.51 ?  245 PRO A CG  1 
ATOM   1641 C CD  . PRO A 1 245 ? 87.012  112.806 98.469  1.00 116.31 ?  245 PRO A CD  1 
ATOM   1642 N N   . HIS A 1 246 ? 87.416  109.361 98.885  1.00 136.68 ?  246 HIS A N   1 
ATOM   1643 C CA  . HIS A 1 246 ? 87.307  107.924 98.670  1.00 137.09 ?  246 HIS A CA  1 
ATOM   1644 C C   . HIS A 1 246 ? 88.666  107.260 98.837  1.00 137.82 ?  246 HIS A C   1 
ATOM   1645 O O   . HIS A 1 246 ? 89.684  107.762 98.355  1.00 142.13 ?  246 HIS A O   1 
ATOM   1646 C CB  . HIS A 1 246 ? 86.746  107.634 97.279  1.00 136.28 ?  246 HIS A CB  1 
ATOM   1647 C CG  . HIS A 1 246 ? 86.139  106.272 97.146  1.00 144.06 ?  246 HIS A CG  1 
ATOM   1648 N ND1 . HIS A 1 246 ? 86.886  105.148 96.867  1.00 140.14 ?  246 HIS A ND1 1 
ATOM   1649 C CD2 . HIS A 1 246 ? 84.855  105.854 97.251  1.00 148.94 ?  246 HIS A CD2 1 
ATOM   1650 C CE1 . HIS A 1 246 ? 86.089  104.095 96.809  1.00 142.26 ?  246 HIS A CE1 1 
ATOM   1651 N NE2 . HIS A 1 246 ? 84.852  104.496 97.039  1.00 144.38 ?  246 HIS A NE2 1 
ATOM   1652 N N   . TRP A 1 247 ? 88.681  106.118 99.527  1.00 116.81 ?  247 TRP A N   1 
ATOM   1653 C CA  . TRP A 1 247 ? 89.953  105.504 99.892  1.00 117.08 ?  247 TRP A CA  1 
ATOM   1654 C C   . TRP A 1 247 ? 90.667  104.920 98.679  1.00 118.58 ?  247 TRP A C   1 
ATOM   1655 O O   . TRP A 1 247 ? 91.895  105.020 98.572  1.00 119.24 ?  247 TRP A O   1 
ATOM   1656 C CB  . TRP A 1 247 ? 89.733  104.443 100.971 1.00 121.33 ?  247 TRP A CB  1 
ATOM   1657 C CG  . TRP A 1 247 ? 89.341  103.086 100.475 1.00 124.69 ?  247 TRP A CG  1 
ATOM   1658 C CD1 . TRP A 1 247 ? 88.076  102.594 100.349 1.00 126.11 ?  247 TRP A CD1 1 
ATOM   1659 C CD2 . TRP A 1 247 ? 90.222  102.031 100.075 1.00 117.92 ?  247 TRP A CD2 1 
ATOM   1660 N NE1 . TRP A 1 247 ? 88.114  101.305 99.879  1.00 122.70 ?  247 TRP A NE1 1 
ATOM   1661 C CE2 . TRP A 1 247 ? 89.421  100.935 99.706  1.00 113.23 ?  247 TRP A CE2 1 
ATOM   1662 C CE3 . TRP A 1 247 ? 91.609  101.910 99.986  1.00 114.84 ?  247 TRP A CE3 1 
ATOM   1663 C CZ2 . TRP A 1 247 ? 89.960  99.738  99.253  1.00 106.58 ?  247 TRP A CZ2 1 
ATOM   1664 C CZ3 . TRP A 1 247 ? 92.141  100.721 99.540  1.00 121.38 ?  247 TRP A CZ3 1 
ATOM   1665 C CH2 . TRP A 1 247 ? 91.320  99.651  99.178  1.00 118.44 ?  247 TRP A CH2 1 
ATOM   1666 N N   . ARG A 1 248 ? 89.923  104.312 97.751  1.00 128.71 ?  248 ARG A N   1 
ATOM   1667 C CA  . ARG A 1 248 ? 90.555  103.728 96.572  1.00 130.32 ?  248 ARG A CA  1 
ATOM   1668 C C   . ARG A 1 248 ? 91.192  104.801 95.701  1.00 131.20 ?  248 ARG A C   1 
ATOM   1669 O O   . ARG A 1 248 ? 92.359  104.681 95.301  1.00 129.44 ?  248 ARG A O   1 
ATOM   1670 C CB  . ARG A 1 248 ? 89.528  102.931 95.768  1.00 124.12 ?  248 ARG A CB  1 
ATOM   1671 C CG  . ARG A 1 248 ? 89.107  101.633 96.427  1.00 131.06 ?  248 ARG A CG  1 
ATOM   1672 C CD  . ARG A 1 248 ? 88.671  100.589 95.417  1.00 131.40 ?  248 ARG A CD  1 
ATOM   1673 N NE  . ARG A 1 248 ? 87.853  99.557  96.042  1.00 127.24 ?  248 ARG A NE  1 
ATOM   1674 C CZ  . ARG A 1 248 ? 88.272  98.329  96.314  1.00 127.86 ?  248 ARG A CZ  1 
ATOM   1675 N NH1 . ARG A 1 248 ? 89.504  97.940  96.030  1.00 127.50 1  248 ARG A NH1 1 
ATOM   1676 N NH2 . ARG A 1 248 ? 87.436  97.471  96.890  1.00 126.20 ?  248 ARG A NH2 1 
ATOM   1677 N N   . HIS A 1 249 ? 90.442  105.862 95.401  1.00 125.78 ?  249 HIS A N   1 
ATOM   1678 C CA  . HIS A 1 249 ? 90.986  106.941 94.588  1.00 123.41 ?  249 HIS A CA  1 
ATOM   1679 C C   . HIS A 1 249 ? 92.126  107.651 95.305  1.00 126.90 ?  249 HIS A C   1 
ATOM   1680 O O   . HIS A 1 249 ? 93.101  108.058 94.669  1.00 134.42 ?  249 HIS A O   1 
ATOM   1681 C CB  . HIS A 1 249 ? 89.885  107.930 94.217  1.00 119.82 ?  249 HIS A CB  1 
ATOM   1682 C CG  . HIS A 1 249 ? 88.684  107.294 93.592  1.00 124.30 ?  249 HIS A CG  1 
ATOM   1683 N ND1 . HIS A 1 249 ? 88.762  106.158 92.817  1.00 131.28 ?  249 HIS A ND1 1 
ATOM   1684 C CD2 . HIS A 1 249 ? 87.376  107.638 93.625  1.00 132.43 ?  249 HIS A CD2 1 
ATOM   1685 C CE1 . HIS A 1 249 ? 87.553  105.828 92.400  1.00 140.31 ?  249 HIS A CE1 1 
ATOM   1686 N NE2 . HIS A 1 249 ? 86.693  106.710 92.877  1.00 138.89 ?  249 HIS A NE2 1 
ATOM   1687 N N   . LEU A 1 250 ? 92.021  107.816 96.626  1.00 102.13 ?  250 LEU A N   1 
ATOM   1688 C CA  . LEU A 1 250 ? 93.107  108.440 97.377  1.00 104.54 ?  250 LEU A CA  1 
ATOM   1689 C C   . LEU A 1 250 ? 94.380  107.607 97.295  1.00 110.15 ?  250 LEU A C   1 
ATOM   1690 O O   . LEU A 1 250 ? 95.469  108.147 97.064  1.00 110.02 ?  250 LEU A O   1 
ATOM   1691 C CB  . LEU A 1 250 ? 92.686  108.641 98.832  1.00 105.47 ?  250 LEU A CB  1 
ATOM   1692 C CG  . LEU A 1 250 ? 93.703  109.104 99.877  1.00 95.23  ?  250 LEU A CG  1 
ATOM   1693 C CD1 . LEU A 1 250 ? 94.555  110.236 99.357  1.00 90.33  ?  250 LEU A CD1 1 
ATOM   1694 C CD2 . LEU A 1 250 ? 92.988  109.526 101.147 1.00 108.64 ?  250 LEU A CD2 1 
ATOM   1695 N N   . GLN A 1 251 ? 94.261  106.290 97.469  1.00 110.71 ?  251 GLN A N   1 
ATOM   1696 C CA  . GLN A 1 251 ? 95.427  105.419 97.368  1.00 104.75 ?  251 GLN A CA  1 
ATOM   1697 C C   . GLN A 1 251 ? 96.035  105.473 95.974  1.00 113.19 ?  251 GLN A C   1 
ATOM   1698 O O   . GLN A 1 251 ? 97.261  105.559 95.827  1.00 111.59 ?  251 GLN A O   1 
ATOM   1699 C CB  . GLN A 1 251 ? 95.036  103.987 97.727  1.00 101.11 ?  251 GLN A CB  1 
ATOM   1700 C CG  . GLN A 1 251 ? 96.145  102.973 97.559  1.00 95.67  ?  251 GLN A CG  1 
ATOM   1701 C CD  . GLN A 1 251 ? 96.991  102.834 98.799  1.00 106.51 ?  251 GLN A CD  1 
ATOM   1702 O OE1 . GLN A 1 251 ? 96.476  102.813 99.915  1.00 107.65 ?  251 GLN A OE1 1 
ATOM   1703 N NE2 . GLN A 1 251 ? 98.298  102.727 98.613  1.00 117.22 ?  251 GLN A NE2 1 
ATOM   1704 N N   . LEU A 1 252 ? 95.193  105.432 94.938  1.00 110.62 ?  252 LEU A N   1 
ATOM   1705 C CA  . LEU A 1 252 ? 95.710  105.486 93.575  1.00 104.66 ?  252 LEU A CA  1 
ATOM   1706 C C   . LEU A 1 252 ? 96.395  106.817 93.295  1.00 102.88 ?  252 LEU A C   1 
ATOM   1707 O O   . LEU A 1 252 ? 97.462  106.855 92.674  1.00 107.44 ?  252 LEU A O   1 
ATOM   1708 C CB  . LEU A 1 252 ? 94.585  105.241 92.573  1.00 100.79 ?  252 LEU A CB  1 
ATOM   1709 C CG  . LEU A 1 252 ? 95.032  105.170 91.116  1.00 98.63  ?  252 LEU A CG  1 
ATOM   1710 C CD1 . LEU A 1 252 ? 95.922  103.962 90.906  1.00 103.44 ?  252 LEU A CD1 1 
ATOM   1711 C CD2 . LEU A 1 252 ? 93.831  105.117 90.194  1.00 105.34 ?  252 LEU A CD2 1 
ATOM   1712 N N   . LEU A 1 253 ? 95.800  107.921 93.752  1.00 104.76 ?  253 LEU A N   1 
ATOM   1713 C CA  . LEU A 1 253 ? 96.388  109.235 93.522  1.00 101.79 ?  253 LEU A CA  1 
ATOM   1714 C C   . LEU A 1 253 ? 97.724  109.368 94.235  1.00 107.39 ?  253 LEU A C   1 
ATOM   1715 O O   . LEU A 1 253 ? 98.668  109.954 93.695  1.00 112.28 ?  253 LEU A O   1 
ATOM   1716 C CB  . LEU A 1 253 ? 95.424  110.326 93.989  1.00 96.89  ?  253 LEU A CB  1 
ATOM   1717 C CG  . LEU A 1 253 ? 95.876  111.787 93.941  1.00 103.43 ?  253 LEU A CG  1 
ATOM   1718 C CD1 . LEU A 1 253 ? 96.617  112.104 92.651  1.00 111.19 ?  253 LEU A CD1 1 
ATOM   1719 C CD2 . LEU A 1 253 ? 94.692  112.713 94.115  1.00 112.19 ?  253 LEU A CD2 1 
ATOM   1720 N N   . VAL A 1 254 ? 97.823  108.844 95.457  1.00 110.43 ?  254 VAL A N   1 
ATOM   1721 C CA  . VAL A 1 254 ? 99.085  108.928 96.182  1.00 112.34 ?  254 VAL A CA  1 
ATOM   1722 C C   . VAL A 1 254 ? 100.161 108.033 95.574  1.00 111.42 ?  254 VAL A C   1 
ATOM   1723 O O   . VAL A 1 254 ? 101.329 108.436 95.522  1.00 110.96 ?  254 VAL A O   1 
ATOM   1724 C CB  . VAL A 1 254 ? 98.869  108.604 97.669  1.00 107.68 ?  254 VAL A CB  1 
ATOM   1725 C CG1 . VAL A 1 254 ? 100.189 108.531 98.395  1.00 106.69 ?  254 VAL A CG1 1 
ATOM   1726 C CG2 . VAL A 1 254 ? 97.997  109.664 98.307  1.00 111.17 ?  254 VAL A CG2 1 
ATOM   1727 N N   . SER A 1 255 ? 99.808  106.840 95.091  1.00 113.96 ?  255 SER A N   1 
ATOM   1728 C CA  . SER A 1 255 ? 100.817 105.910 94.596  1.00 118.34 ?  255 SER A CA  1 
ATOM   1729 C C   . SER A 1 255 ? 101.078 105.997 93.097  1.00 117.57 ?  255 SER A C   1 
ATOM   1730 O O   . SER A 1 255 ? 101.973 105.302 92.607  1.00 117.75 ?  255 SER A O   1 
ATOM   1731 C CB  . SER A 1 255 ? 100.426 104.470 94.940  1.00 111.76 ?  255 SER A CB  1 
ATOM   1732 O OG  . SER A 1 255 ? 100.624 104.205 96.317  1.00 117.46 ?  255 SER A OG  1 
ATOM   1733 N N   . ALA A 1 256 ? 100.334 106.812 92.354  1.00 111.94 ?  256 ALA A N   1 
ATOM   1734 C CA  . ALA A 1 256 ? 100.553 106.878 90.912  1.00 106.88 ?  256 ALA A CA  1 
ATOM   1735 C C   . ALA A 1 256 ? 101.781 107.697 90.513  1.00 111.15 ?  256 ALA A C   1 
ATOM   1736 O O   . ALA A 1 256 ? 102.467 107.316 89.556  1.00 121.22 ?  256 ALA A O   1 
ATOM   1737 C CB  . ALA A 1 256 ? 99.306  107.421 90.209  1.00 109.76 ?  256 ALA A CB  1 
ATOM   1738 N N   . PRO A 1 257 ? 102.089 108.824 91.174  1.00 109.43 ?  257 PRO A N   1 
ATOM   1739 C CA  . PRO A 1 257 ? 103.306 109.565 90.801  1.00 119.24 ?  257 PRO A CA  1 
ATOM   1740 C C   . PRO A 1 257 ? 104.567 108.722 90.787  1.00 118.24 ?  257 PRO A C   1 
ATOM   1741 O O   . PRO A 1 257 ? 105.526 109.072 90.087  1.00 116.08 ?  257 PRO A O   1 
ATOM   1742 C CB  . PRO A 1 257 ? 103.394 110.663 91.870  1.00 114.97 ?  257 PRO A CB  1 
ATOM   1743 C CG  . PRO A 1 257 ? 102.044 110.754 92.485  1.00 111.55 ?  257 PRO A CG  1 
ATOM   1744 C CD  . PRO A 1 257 ? 101.161 109.690 91.920  1.00 103.65 ?  257 PRO A CD  1 
ATOM   1745 N N   . PHE A 1 258 ? 104.610 107.630 91.547  1.00 117.08 ?  258 PHE A N   1 
ATOM   1746 C CA  . PHE A 1 258 ? 105.784 106.771 91.503  1.00 113.36 ?  258 PHE A CA  1 
ATOM   1747 C C   . PHE A 1 258 ? 105.979 106.107 90.147  1.00 113.19 ?  258 PHE A C   1 
ATOM   1748 O O   . PHE A 1 258 ? 107.113 105.757 89.815  1.00 120.35 ?  258 PHE A O   1 
ATOM   1749 C CB  . PHE A 1 258 ? 105.705 105.721 92.609  1.00 113.41 ?  258 PHE A CB  1 
ATOM   1750 C CG  . PHE A 1 258 ? 106.018 106.263 93.974  1.00 112.56 ?  258 PHE A CG  1 
ATOM   1751 C CD1 . PHE A 1 258 ? 107.302 106.201 94.479  1.00 113.05 ?  258 PHE A CD1 1 
ATOM   1752 C CD2 . PHE A 1 258 ? 105.031 106.845 94.745  1.00 116.81 ?  258 PHE A CD2 1 
ATOM   1753 C CE1 . PHE A 1 258 ? 107.591 106.700 95.730  1.00 115.10 ?  258 PHE A CE1 1 
ATOM   1754 C CE2 . PHE A 1 258 ? 105.317 107.346 95.996  1.00 109.47 ?  258 PHE A CE2 1 
ATOM   1755 C CZ  . PHE A 1 258 ? 106.598 107.273 96.488  1.00 111.33 ?  258 PHE A CZ  1 
ATOM   1756 N N   . PHE A 1 259 ? 104.928 105.950 89.343  1.00 124.67 ?  259 PHE A N   1 
ATOM   1757 C CA  . PHE A 1 259 ? 105.113 105.506 87.967  1.00 128.82 ?  259 PHE A CA  1 
ATOM   1758 C C   . PHE A 1 259 ? 105.898 106.510 87.136  1.00 137.80 ?  259 PHE A C   1 
ATOM   1759 O O   . PHE A 1 259 ? 106.828 106.120 86.421  1.00 141.04 ?  259 PHE A O   1 
ATOM   1760 C CB  . PHE A 1 259 ? 103.761 105.240 87.303  1.00 129.28 ?  259 PHE A CB  1 
ATOM   1761 C CG  . PHE A 1 259 ? 103.236 103.857 87.539  1.00 134.90 ?  259 PHE A CG  1 
ATOM   1762 C CD1 . PHE A 1 259 ? 103.929 102.753 87.076  1.00 127.82 ?  259 PHE A CD1 1 
ATOM   1763 C CD2 . PHE A 1 259 ? 102.049 103.660 88.225  1.00 137.20 ?  259 PHE A CD2 1 
ATOM   1764 C CE1 . PHE A 1 259 ? 103.450 101.479 87.294  1.00 133.54 ?  259 PHE A CE1 1 
ATOM   1765 C CE2 . PHE A 1 259 ? 101.565 102.388 88.446  1.00 131.02 ?  259 PHE A CE2 1 
ATOM   1766 C CZ  . PHE A 1 259 ? 102.267 101.295 87.979  1.00 132.38 ?  259 PHE A CZ  1 
ATOM   1767 N N   . ALA A 1 260 ? 105.557 107.798 87.223  1.00 134.81 ?  260 ALA A N   1 
ATOM   1768 C CA  . ALA A 1 260 ? 106.358 108.814 86.552  1.00 132.30 ?  260 ALA A CA  1 
ATOM   1769 C C   . ALA A 1 260 ? 107.764 108.875 87.128  1.00 123.78 ?  260 ALA A C   1 
ATOM   1770 O O   . ALA A 1 260 ? 108.728 109.128 86.395  1.00 124.43 ?  260 ALA A O   1 
ATOM   1771 C CB  . ALA A 1 260 ? 105.679 110.179 86.659  1.00 127.67 ?  260 ALA A CB  1 
ATOM   1772 N N   . PHE A 1 261 ? 107.896 108.655 88.437  1.00 127.61 ?  261 PHE A N   1 
ATOM   1773 C CA  . PHE A 1 261 ? 109.221 108.606 89.044  1.00 133.37 ?  261 PHE A CA  1 
ATOM   1774 C C   . PHE A 1 261 ? 110.063 107.489 88.440  1.00 130.63 ?  261 PHE A C   1 
ATOM   1775 O O   . PHE A 1 261 ? 111.235 107.698 88.115  1.00 132.06 ?  261 PHE A O   1 
ATOM   1776 C CB  . PHE A 1 261 ? 109.104 108.440 90.558  1.00 141.15 ?  261 PHE A CB  1 
ATOM   1777 C CG  . PHE A 1 261 ? 108.587 109.661 91.262  1.00 140.35 ?  261 PHE A CG  1 
ATOM   1778 C CD1 . PHE A 1 261 ? 108.669 110.906 90.666  1.00 136.32 ?  261 PHE A CD1 1 
ATOM   1779 C CD2 . PHE A 1 261 ? 108.016 109.563 92.517  1.00 136.30 ?  261 PHE A CD2 1 
ATOM   1780 C CE1 . PHE A 1 261 ? 108.194 112.030 91.310  1.00 139.05 ?  261 PHE A CE1 1 
ATOM   1781 C CE2 . PHE A 1 261 ? 107.539 110.682 93.164  1.00 134.87 ?  261 PHE A CE2 1 
ATOM   1782 C CZ  . PHE A 1 261 ? 107.628 111.917 92.560  1.00 136.86 ?  261 PHE A CZ  1 
ATOM   1783 N N   . PHE A 1 262 ? 109.482 106.301 88.272  1.00 124.98 ?  262 PHE A N   1 
ATOM   1784 C CA  . PHE A 1 262 ? 110.209 105.210 87.633  1.00 131.76 ?  262 PHE A CA  1 
ATOM   1785 C C   . PHE A 1 262 ? 110.495 105.515 86.170  1.00 129.21 ?  262 PHE A C   1 
ATOM   1786 O O   . PHE A 1 262 ? 111.532 105.102 85.641  1.00 134.39 ?  262 PHE A O   1 
ATOM   1787 C CB  . PHE A 1 262 ? 109.423 103.904 87.760  1.00 131.64 ?  262 PHE A CB  1 
ATOM   1788 C CG  . PHE A 1 262 ? 109.784 102.873 86.728  1.00 127.99 ?  262 PHE A CG  1 
ATOM   1789 C CD1 . PHE A 1 262 ? 110.907 102.082 86.885  1.00 131.33 ?  262 PHE A CD1 1 
ATOM   1790 C CD2 . PHE A 1 262 ? 108.995 102.689 85.607  1.00 130.29 ?  262 PHE A CD2 1 
ATOM   1791 C CE1 . PHE A 1 262 ? 111.239 101.134 85.940  1.00 128.98 ?  262 PHE A CE1 1 
ATOM   1792 C CE2 . PHE A 1 262 ? 109.324 101.743 84.660  1.00 132.14 ?  262 PHE A CE2 1 
ATOM   1793 C CZ  . PHE A 1 262 ? 110.447 100.964 84.827  1.00 128.39 ?  262 PHE A CZ  1 
ATOM   1794 N N   . ILE A 1 263 ? 109.629 106.301 85.544  1.00 122.70 ?  263 ILE A N   1 
ATOM   1795 C CA  . ILE A 1 263 ? 109.819 106.657 84.144  1.00 130.83 ?  263 ILE A CA  1 
ATOM   1796 C C   . ILE A 1 263 ? 110.979 107.617 83.944  1.00 136.07 ?  263 ILE A C   1 
ATOM   1797 O O   . ILE A 1 263 ? 111.720 107.501 82.972  1.00 136.66 ?  263 ILE A O   1 
ATOM   1798 C CB  . ILE A 1 263 ? 108.555 107.299 83.560  1.00 131.09 ?  263 ILE A CB  1 
ATOM   1799 C CG1 . ILE A 1 263 ? 107.439 106.261 83.455  1.00 131.55 ?  263 ILE A CG1 1 
ATOM   1800 C CG2 . ILE A 1 263 ? 108.839 107.901 82.194  1.00 127.29 ?  263 ILE A CG2 1 
ATOM   1801 C CD1 . ILE A 1 263 ? 106.125 106.827 82.965  1.00 128.16 ?  263 ILE A CD1 1 
ATOM   1802 N N   . TYR A 1 264 ? 111.138 108.561 84.862  1.00 144.71 ?  264 TYR A N   1 
ATOM   1803 C CA  . TYR A 1 264 ? 112.200 109.554 84.722  1.00 140.62 ?  264 TYR A CA  1 
ATOM   1804 C C   . TYR A 1 264 ? 113.465 109.161 85.461  1.00 137.31 ?  264 TYR A C   1 
ATOM   1805 O O   . TYR A 1 264 ? 114.497 109.807 85.304  1.00 134.92 ?  264 TYR A O   1 
ATOM   1806 C CB  . TYR A 1 264 ? 111.736 110.919 85.224  1.00 140.82 ?  264 TYR A CB  1 
ATOM   1807 C CG  . TYR A 1 264 ? 112.651 112.045 84.815  1.00 143.63 ?  264 TYR A CG  1 
ATOM   1808 C CD1 . TYR A 1 264 ? 112.740 112.442 83.489  1.00 143.34 ?  264 TYR A CD1 1 
ATOM   1809 C CD2 . TYR A 1 264 ? 113.426 112.711 85.750  1.00 147.37 ?  264 TYR A CD2 1 
ATOM   1810 C CE1 . TYR A 1 264 ? 113.576 113.471 83.104  1.00 145.27 ?  264 TYR A CE1 1 
ATOM   1811 C CE2 . TYR A 1 264 ? 114.266 113.741 85.374  1.00 147.10 ?  264 TYR A CE2 1 
ATOM   1812 C CZ  . TYR A 1 264 ? 114.337 114.117 84.051  1.00 148.15 ?  264 TYR A CZ  1 
ATOM   1813 O OH  . TYR A 1 264 ? 115.172 115.145 83.675  1.00 146.08 ?  264 TYR A OH  1 
ATOM   1814 N N   . SER A 1 265 ? 113.402 108.110 86.267  1.00 134.41 ?  265 SER A N   1 
ATOM   1815 C CA  . SER A 1 265 ? 114.583 107.773 87.051  1.00 135.01 ?  265 SER A CA  1 
ATOM   1816 C C   . SER A 1 265 ? 115.532 106.823 86.335  1.00 137.00 ?  265 SER A C   1 
ATOM   1817 O O   . SER A 1 265 ? 116.540 106.426 86.927  1.00 139.79 ?  265 SER A O   1 
ATOM   1818 C CB  . SER A 1 265 ? 114.164 107.168 88.389  1.00 135.40 ?  265 SER A CB  1 
ATOM   1819 O OG  . SER A 1 265 ? 115.294 106.790 89.151  1.00 137.25 ?  265 SER A OG  1 
ATOM   1820 N N   . TRP A 1 266 ? 115.236 106.434 85.094  1.00 134.32 ?  266 TRP A N   1 
ATOM   1821 C CA  . TRP A 1 266 ? 116.210 105.681 84.312  1.00 131.87 ?  266 TRP A CA  1 
ATOM   1822 C C   . TRP A 1 266 ? 117.426 106.525 83.956  1.00 138.56 ?  266 TRP A C   1 
ATOM   1823 O O   . TRP A 1 266 ? 118.444 105.974 83.525  1.00 140.06 ?  266 TRP A O   1 
ATOM   1824 C CB  . TRP A 1 266 ? 115.561 105.139 83.037  1.00 134.06 ?  266 TRP A CB  1 
ATOM   1825 C CG  . TRP A 1 266 ? 114.938 103.784 83.195  1.00 141.29 ?  266 TRP A CG  1 
ATOM   1826 C CD1 . TRP A 1 266 ? 113.606 103.493 83.207  1.00 140.45 ?  266 TRP A CD1 1 
ATOM   1827 C CD2 . TRP A 1 266 ? 115.623 102.535 83.349  1.00 142.24 ?  266 TRP A CD2 1 
ATOM   1828 N NE1 . TRP A 1 266 ? 113.418 102.142 83.367  1.00 135.77 ?  266 TRP A NE1 1 
ATOM   1829 C CE2 . TRP A 1 266 ? 114.641 101.531 83.456  1.00 141.33 ?  266 TRP A CE2 1 
ATOM   1830 C CE3 . TRP A 1 266 ? 116.970 102.169 83.410  1.00 136.60 ?  266 TRP A CE3 1 
ATOM   1831 C CZ2 . TRP A 1 266 ? 114.963 100.187 83.622  1.00 139.29 ?  266 TRP A CZ2 1 
ATOM   1832 C CZ3 . TRP A 1 266 ? 117.287 100.833 83.575  1.00 137.89 ?  266 TRP A CZ3 1 
ATOM   1833 C CH2 . TRP A 1 266 ? 116.289 99.860  83.678  1.00 138.71 ?  266 TRP A CH2 1 
ATOM   1834 N N   . PHE A 1 267 ? 117.341 107.841 84.131  1.00 153.16 ?  267 PHE A N   1 
ATOM   1835 C CA  . PHE A 1 267 ? 118.383 108.774 83.725  1.00 149.56 ?  267 PHE A CA  1 
ATOM   1836 C C   . PHE A 1 267 ? 119.352 109.123 84.848  1.00 146.96 ?  267 PHE A C   1 
ATOM   1837 O O   . PHE A 1 267 ? 120.227 109.971 84.645  1.00 147.94 ?  267 PHE A O   1 
ATOM   1838 C CB  . PHE A 1 267 ? 117.756 110.067 83.182  1.00 148.38 ?  267 PHE A CB  1 
ATOM   1839 C CG  . PHE A 1 267 ? 116.993 109.894 81.891  1.00 150.69 ?  267 PHE A CG  1 
ATOM   1840 C CD1 . PHE A 1 267 ? 116.559 111.004 81.186  1.00 149.38 ?  267 PHE A CD1 1 
ATOM   1841 C CD2 . PHE A 1 267 ? 116.729 108.637 81.371  1.00 151.54 ?  267 PHE A CD2 1 
ATOM   1842 C CE1 . PHE A 1 267 ? 115.862 110.863 80.002  1.00 150.75 ?  267 PHE A CE1 1 
ATOM   1843 C CE2 . PHE A 1 267 ? 116.034 108.490 80.189  1.00 149.24 ?  267 PHE A CE2 1 
ATOM   1844 C CZ  . PHE A 1 267 ? 115.601 109.604 79.502  1.00 150.78 ?  267 PHE A CZ  1 
ATOM   1845 N N   . PHE A 1 268 ? 119.219 108.508 86.021  1.00 139.90 ?  268 PHE A N   1 
ATOM   1846 C CA  . PHE A 1 268 ? 120.098 108.834 87.135  1.00 138.44 ?  268 PHE A CA  1 
ATOM   1847 C C   . PHE A 1 268 ? 121.531 108.409 86.838  1.00 141.03 ?  268 PHE A C   1 
ATOM   1848 O O   . PHE A 1 268 ? 121.800 107.645 85.908  1.00 143.07 ?  268 PHE A O   1 
ATOM   1849 C CB  . PHE A 1 268 ? 119.622 108.158 88.422  1.00 135.16 ?  268 PHE A CB  1 
ATOM   1850 C CG  . PHE A 1 268 ? 118.423 108.810 89.046  1.00 143.58 ?  268 PHE A CG  1 
ATOM   1851 C CD1 . PHE A 1 268 ? 117.975 110.041 88.603  1.00 148.36 ?  268 PHE A CD1 1 
ATOM   1852 C CD2 . PHE A 1 268 ? 117.753 108.196 90.089  1.00 140.60 ?  268 PHE A CD2 1 
ATOM   1853 C CE1 . PHE A 1 268 ? 116.876 110.640 89.180  1.00 143.42 ?  268 PHE A CE1 1 
ATOM   1854 C CE2 . PHE A 1 268 ? 116.655 108.791 90.670  1.00 134.88 ?  268 PHE A CE2 1 
ATOM   1855 C CZ  . PHE A 1 268 ? 116.215 110.014 90.215  1.00 135.32 ?  268 PHE A CZ  1 
ATOM   1856 N N   . ILE A 1 269 ? 122.456 108.924 87.643  1.00 151.97 ?  269 ILE A N   1 
ATOM   1857 C CA  . ILE A 1 269 ? 123.872 108.596 87.536  1.00 151.77 ?  269 ILE A CA  1 
ATOM   1858 C C   . ILE A 1 269 ? 124.283 107.830 88.783  1.00 151.42 ?  269 ILE A C   1 
ATOM   1859 O O   . ILE A 1 269 ? 124.046 108.287 89.908  1.00 153.08 ?  269 ILE A O   1 
ATOM   1860 C CB  . ILE A 1 269 ? 124.726 109.862 87.358  1.00 147.90 ?  269 ILE A CB  1 
ATOM   1861 C CG1 . ILE A 1 269 ? 124.307 110.608 86.090  1.00 149.87 ?  269 ILE A CG1 1 
ATOM   1862 C CG2 . ILE A 1 269 ? 126.200 109.502 87.312  1.00 149.09 ?  269 ILE A CG2 1 
ATOM   1863 C CD1 . ILE A 1 269 ? 125.311 111.631 85.618  1.00 149.10 ?  269 ILE A CD1 1 
ATOM   1864 N N   . GLU A 1 270 ? 124.893 106.665 88.586  1.00 155.14 ?  270 GLU A N   1 
ATOM   1865 C CA  . GLU A 1 270 ? 125.286 105.820 89.702  1.00 151.95 ?  270 GLU A CA  1 
ATOM   1866 C C   . GLU A 1 270 ? 126.296 106.533 90.592  1.00 155.59 ?  270 GLU A C   1 
ATOM   1867 O O   . GLU A 1 270 ? 127.134 107.308 90.125  1.00 165.85 ?  270 GLU A O   1 
ATOM   1868 C CB  . GLU A 1 270 ? 125.878 104.507 89.194  1.00 151.17 ?  270 GLU A CB  1 
ATOM   1869 C CG  . GLU A 1 270 ? 125.996 103.423 90.251  1.00 154.93 ?  270 GLU A CG  1 
ATOM   1870 C CD  . GLU A 1 270 ? 124.849 102.436 90.206  1.00 164.22 ?  270 GLU A CD  1 
ATOM   1871 O OE1 . GLU A 1 270 ? 124.926 101.471 89.418  1.00 166.52 ?  270 GLU A OE1 1 
ATOM   1872 O OE2 . GLU A 1 270 ? 123.872 102.620 90.962  1.00 164.39 -1 270 GLU A OE2 1 
ATOM   1873 N N   . SER A 1 271 ? 126.197 106.272 91.893  1.00 165.06 ?  271 SER A N   1 
ATOM   1874 C CA  . SER A 1 271 ? 127.133 106.849 92.848  1.00 170.36 ?  271 SER A CA  1 
ATOM   1875 C C   . SER A 1 271 ? 128.540 106.334 92.582  1.00 174.08 ?  271 SER A C   1 
ATOM   1876 O O   . SER A 1 271 ? 128.787 105.125 92.619  1.00 175.77 ?  271 SER A O   1 
ATOM   1877 C CB  . SER A 1 271 ? 126.700 106.510 94.272  1.00 170.40 ?  271 SER A CB  1 
ATOM   1878 O OG  . SER A 1 271 ? 127.626 107.011 95.218  1.00 172.68 ?  271 SER A OG  1 
ATOM   1879 N N   . ALA A 1 272 ? 129.466 107.259 92.316  1.00 170.29 ?  272 ALA A N   1 
ATOM   1880 C CA  . ALA A 1 272 ? 130.829 106.864 91.978  1.00 168.02 ?  272 ALA A CA  1 
ATOM   1881 C C   . ALA A 1 272 ? 131.540 106.213 93.156  1.00 169.58 ?  272 ALA A C   1 
ATOM   1882 O O   . ALA A 1 272 ? 132.428 105.375 92.954  1.00 170.77 ?  272 ALA A O   1 
ATOM   1883 C CB  . ALA A 1 272 ? 131.618 108.074 91.482  1.00 171.14 ?  272 ALA A CB  1 
ATOM   1884 N N   . ARG A 1 273 ? 131.175 106.583 94.386  1.00 181.55 ?  273 ARG A N   1 
ATOM   1885 C CA  . ARG A 1 273 ? 131.796 105.967 95.554  1.00 182.34 ?  273 ARG A CA  1 
ATOM   1886 C C   . ARG A 1 273 ? 131.502 104.474 95.608  1.00 182.20 ?  273 ARG A C   1 
ATOM   1887 O O   . ARG A 1 273 ? 132.388 103.671 95.923  1.00 181.26 ?  273 ARG A O   1 
ATOM   1888 C CB  . ARG A 1 273 ? 131.316 106.654 96.831  1.00 180.20 ?  273 ARG A CB  1 
ATOM   1889 C CG  . ARG A 1 273 ? 131.544 108.153 96.850  1.00 183.55 ?  273 ARG A CG  1 
ATOM   1890 C CD  . ARG A 1 273 ? 131.467 108.702 98.263  1.00 183.17 ?  273 ARG A CD  1 
ATOM   1891 N NE  . ARG A 1 273 ? 132.564 108.221 99.093  1.00 182.27 ?  273 ARG A NE  1 
ATOM   1892 C CZ  . ARG A 1 273 ? 132.569 108.252 100.419 1.00 180.80 ?  273 ARG A CZ  1 
ATOM   1893 N NH1 . ARG A 1 273 ? 131.543 108.732 101.102 1.00 180.57 1  273 ARG A NH1 1 
ATOM   1894 N NH2 . ARG A 1 273 ? 133.629 107.789 101.075 1.00 180.55 ?  273 ARG A NH2 1 
ATOM   1895 N N   . TRP A 1 274 ? 130.263 104.081 95.301  1.00 181.00 ?  274 TRP A N   1 
ATOM   1896 C CA  . TRP A 1 274 ? 129.939 102.660 95.261  1.00 180.74 ?  274 TRP A CA  1 
ATOM   1897 C C   . TRP A 1 274 ? 130.711 101.951 94.158  1.00 183.04 ?  274 TRP A C   1 
ATOM   1898 O O   . TRP A 1 274 ? 131.164 100.815 94.342  1.00 184.76 ?  274 TRP A O   1 
ATOM   1899 C CB  . TRP A 1 274 ? 128.441 102.452 95.060  1.00 174.65 ?  274 TRP A CB  1 
ATOM   1900 C CG  . TRP A 1 274 ? 128.102 101.008 94.899  1.00 176.06 ?  274 TRP A CG  1 
ATOM   1901 C CD1 . TRP A 1 274 ? 128.014 100.075 95.888  1.00 177.32 ?  274 TRP A CD1 1 
ATOM   1902 C CD2 . TRP A 1 274 ? 127.857 100.316 93.671  1.00 177.40 ?  274 TRP A CD2 1 
ATOM   1903 N NE1 . TRP A 1 274 ? 127.703 98.849  95.355  1.00 181.26 ?  274 TRP A NE1 1 
ATOM   1904 C CE2 . TRP A 1 274 ? 127.603 98.970  93.994  1.00 181.54 ?  274 TRP A CE2 1 
ATOM   1905 C CE3 . TRP A 1 274 ? 127.816 100.706 92.330  1.00 175.37 ?  274 TRP A CE3 1 
ATOM   1906 C CZ2 . TRP A 1 274 ? 127.313 98.012  93.027  1.00 180.69 ?  274 TRP A CZ2 1 
ATOM   1907 C CZ3 . TRP A 1 274 ? 127.527 99.754  91.371  1.00 177.28 ?  274 TRP A CZ3 1 
ATOM   1908 C CH2 . TRP A 1 274 ? 127.280 98.423  91.724  1.00 177.94 ?  274 TRP A CH2 1 
ATOM   1909 N N   . HIS A 1 275 ? 130.853 102.595 92.997  1.00 183.17 ?  275 HIS A N   1 
ATOM   1910 C CA  . HIS A 1 275 ? 131.618 101.993 91.912  1.00 181.04 ?  275 HIS A CA  1 
ATOM   1911 C C   . HIS A 1 275 ? 133.065 101.768 92.327  1.00 181.47 ?  275 HIS A C   1 
ATOM   1912 O O   . HIS A 1 275 ? 133.649 100.721 92.024  1.00 180.45 ?  275 HIS A O   1 
ATOM   1913 C CB  . HIS A 1 275 ? 131.549 102.875 90.666  1.00 177.42 ?  275 HIS A CB  1 
ATOM   1914 C CG  . HIS A 1 275 ? 130.380 102.582 89.781  1.00 175.72 ?  275 HIS A CG  1 
ATOM   1915 N ND1 . HIS A 1 275 ? 129.935 101.301 89.536  1.00 178.29 ?  275 HIS A ND1 1 
ATOM   1916 C CD2 . HIS A 1 275 ? 129.568 103.404 89.076  1.00 179.09 ?  275 HIS A CD2 1 
ATOM   1917 C CE1 . HIS A 1 275 ? 128.894 101.347 88.724  1.00 182.05 ?  275 HIS A CE1 1 
ATOM   1918 N NE2 . HIS A 1 275 ? 128.652 102.611 88.427  1.00 180.99 ?  275 HIS A NE2 1 
ATOM   1919 N N   . SER A 1 276 ? 133.658 102.741 93.021  1.00 186.43 ?  276 SER A N   1 
ATOM   1920 C CA  . SER A 1 276 ? 135.014 102.565 93.527  1.00 186.22 ?  276 SER A CA  1 
ATOM   1921 C C   . SER A 1 276 ? 135.080 101.435 94.547  1.00 185.68 ?  276 SER A C   1 
ATOM   1922 O O   . SER A 1 276 ? 135.997 100.607 94.505  1.00 188.53 ?  276 SER A O   1 
ATOM   1923 C CB  . SER A 1 276 ? 135.516 103.870 94.141  1.00 187.05 ?  276 SER A CB  1 
ATOM   1924 O OG  . SER A 1 276 ? 134.962 104.071 95.429  1.00 186.33 ?  276 SER A OG  1 
ATOM   1925 N N   . SER A 1 277 ? 134.110 101.378 95.463  1.00 184.47 ?  277 SER A N   1 
ATOM   1926 C CA  . SER A 1 277 ? 134.130 100.351 96.500  1.00 186.81 ?  277 SER A CA  1 
ATOM   1927 C C   . SER A 1 277 ? 134.013 98.955  95.902  1.00 186.69 ?  277 SER A C   1 
ATOM   1928 O O   . SER A 1 277 ? 134.694 98.023  96.345  1.00 186.69 ?  277 SER A O   1 
ATOM   1929 C CB  . SER A 1 277 ? 133.005 100.598 97.505  1.00 187.81 ?  277 SER A CB  1 
ATOM   1930 O OG  . SER A 1 277 ? 131.757 100.173 96.986  1.00 190.07 ?  277 SER A OG  1 
ATOM   1931 N N   . SER A 1 278 ? 133.151 98.790  94.896  1.00 191.77 ?  278 SER A N   1 
ATOM   1932 C CA  . SER A 1 278 ? 133.006 97.487  94.256  1.00 192.34 ?  278 SER A CA  1 
ATOM   1933 C C   . SER A 1 278 ? 134.254 97.104  93.472  1.00 192.68 ?  278 SER A C   1 
ATOM   1934 O O   . SER A 1 278 ? 134.471 95.920  93.192  1.00 194.49 ?  278 SER A O   1 
ATOM   1935 C CB  . SER A 1 278 ? 131.780 97.481  93.343  1.00 192.39 ?  278 SER A CB  1 
ATOM   1936 O OG  . SER A 1 278 ? 130.590 97.677  94.087  1.00 192.38 ?  278 SER A OG  1 
ATOM   1937 N N   . GLY A 1 279 ? 135.078 98.081  93.108  1.00 200.74 ?  279 GLY A N   1 
ATOM   1938 C CA  . GLY A 1 279 ? 136.316 97.831  92.391  1.00 202.70 ?  279 GLY A CA  1 
ATOM   1939 C C   . GLY A 1 279 ? 136.296 98.220  90.929  1.00 203.30 ?  279 GLY A C   1 
ATOM   1940 O O   . GLY A 1 279 ? 137.339 98.121  90.266  1.00 202.35 ?  279 GLY A O   1 
ATOM   1941 N N   . ARG A 1 280 ? 135.157 98.653  90.387  1.00 203.85 ?  280 ARG A N   1 
ATOM   1942 C CA  . ARG A 1 280 ? 135.075 99.073  88.989  1.00 202.71 ?  280 ARG A CA  1 
ATOM   1943 C C   . ARG A 1 280 ? 135.342 100.573 88.915  1.00 203.50 ?  280 ARG A C   1 
ATOM   1944 O O   . ARG A 1 280 ? 134.432 101.404 88.883  1.00 205.77 ?  280 ARG A O   1 
ATOM   1945 C CB  . ARG A 1 280 ? 133.719 98.710  88.397  1.00 201.04 ?  280 ARG A CB  1 
ATOM   1946 C CG  . ARG A 1 280 ? 133.503 97.221  88.203  1.00 201.48 ?  280 ARG A CG  1 
ATOM   1947 C CD  . ARG A 1 280 ? 132.604 96.959  87.010  1.00 202.96 ?  280 ARG A CD  1 
ATOM   1948 N NE  . ARG A 1 280 ? 133.134 97.561  85.792  1.00 202.43 ?  280 ARG A NE  1 
ATOM   1949 C CZ  . ARG A 1 280 ? 132.499 97.576  84.628  1.00 204.65 ?  280 ARG A CZ  1 
ATOM   1950 N NH1 . ARG A 1 280 ? 131.302 97.031  84.486  1.00 203.63 1  280 ARG A NH1 1 
ATOM   1951 N NH2 . ARG A 1 280 ? 133.079 98.155  83.581  1.00 206.35 ?  280 ARG A NH2 1 
ATOM   1952 N N   . LEU A 1 281 ? 136.630 100.921 88.889  1.00 199.18 ?  281 LEU A N   1 
ATOM   1953 C CA  . LEU A 1 281 ? 137.014 102.323 88.776  1.00 198.93 ?  281 LEU A CA  1 
ATOM   1954 C C   . LEU A 1 281 ? 136.767 102.876 87.380  1.00 200.64 ?  281 LEU A C   1 
ATOM   1955 O O   . LEU A 1 281 ? 136.733 104.100 87.209  1.00 200.27 ?  281 LEU A O   1 
ATOM   1956 C CB  . LEU A 1 281 ? 138.485 102.514 89.158  1.00 198.70 ?  281 LEU A CB  1 
ATOM   1957 C CG  . LEU A 1 281 ? 138.923 102.291 90.612  1.00 198.38 ?  281 LEU A CG  1 
ATOM   1958 C CD1 . LEU A 1 281 ? 138.980 100.816 90.989  1.00 198.84 ?  281 LEU A CD1 1 
ATOM   1959 C CD2 . LEU A 1 281 ? 140.263 102.960 90.873  1.00 197.80 ?  281 LEU A CD2 1 
ATOM   1960 N N   . ASP A 1 282 ? 136.595 102.007 86.380  1.00 206.30 ?  282 ASP A N   1 
ATOM   1961 C CA  . ASP A 1 282 ? 136.277 102.480 85.038  1.00 206.35 ?  282 ASP A CA  1 
ATOM   1962 C C   . ASP A 1 282 ? 134.937 103.205 85.018  1.00 205.08 ?  282 ASP A C   1 
ATOM   1963 O O   . ASP A 1 282 ? 134.813 104.288 84.435  1.00 203.52 ?  282 ASP A O   1 
ATOM   1964 C CB  . ASP A 1 282 ? 136.263 101.306 84.060  1.00 206.53 ?  282 ASP A CB  1 
ATOM   1965 C CG  . ASP A 1 282 ? 137.555 100.514 84.084  1.00 206.22 ?  282 ASP A CG  1 
ATOM   1966 O OD1 . ASP A 1 282 ? 138.489 100.923 84.805  1.00 205.45 ?  282 ASP A OD1 1 
ATOM   1967 O OD2 . ASP A 1 282 ? 137.635 99.482  83.386  1.00 205.48 -1 282 ASP A OD2 1 
ATOM   1968 N N   . LEU A 1 283 ? 133.926 102.629 85.665  1.00 197.94 ?  283 LEU A N   1 
ATOM   1969 C CA  . LEU A 1 283 ? 132.634 103.289 85.777  1.00 196.71 ?  283 LEU A CA  1 
ATOM   1970 C C   . LEU A 1 283 ? 132.687 104.516 86.675  1.00 198.77 ?  283 LEU A C   1 
ATOM   1971 O O   . LEU A 1 283 ? 131.932 105.467 86.451  1.00 200.59 ?  283 LEU A O   1 
ATOM   1972 C CB  . LEU A 1 283 ? 131.583 102.301 86.289  1.00 195.12 ?  283 LEU A CB  1 
ATOM   1973 C CG  . LEU A 1 283 ? 131.523 101.005 85.476  1.00 197.12 ?  283 LEU A CG  1 
ATOM   1974 C CD1 . LEU A 1 283 ? 130.469 100.055 86.022  1.00 198.30 ?  283 LEU A CD1 1 
ATOM   1975 C CD2 . LEU A 1 283 ? 131.269 101.307 84.006  1.00 196.02 ?  283 LEU A CD2 1 
ATOM   1976 N N   . THR A 1 284 ? 133.574 104.525 87.675  1.00 198.15 ?  284 THR A N   1 
ATOM   1977 C CA  . THR A 1 284 ? 133.794 105.743 88.450  1.00 195.92 ?  284 THR A CA  1 
ATOM   1978 C C   . THR A 1 284 ? 134.301 106.868 87.559  1.00 194.14 ?  284 THR A C   1 
ATOM   1979 O O   . THR A 1 284 ? 133.810 108.001 87.631  1.00 193.07 ?  284 THR A O   1 
ATOM   1980 C CB  . THR A 1 284 ? 134.787 105.478 89.583  1.00 193.46 ?  284 THR A CB  1 
ATOM   1981 O OG1 . THR A 1 284 ? 134.208 104.577 90.534  1.00 199.62 ?  284 THR A OG1 1 
ATOM   1982 C CG2 . THR A 1 284 ? 135.156 106.776 90.283  1.00 189.86 ?  284 THR A CG2 1 
ATOM   1983 N N   . LEU A 1 285 ? 135.281 106.567 86.704  1.00 196.21 ?  285 LEU A N   1 
ATOM   1984 C CA  . LEU A 1 285 ? 135.794 107.566 85.774  1.00 196.77 ?  285 LEU A CA  1 
ATOM   1985 C C   . LEU A 1 285 ? 134.708 108.003 84.797  1.00 194.62 ?  285 LEU A C   1 
ATOM   1986 O O   . LEU A 1 285 ? 134.594 109.190 84.476  1.00 194.04 ?  285 LEU A O   1 
ATOM   1987 C CB  . LEU A 1 285 ? 137.008 106.998 85.032  1.00 196.40 ?  285 LEU A CB  1 
ATOM   1988 C CG  . LEU A 1 285 ? 137.682 107.702 83.848  1.00 195.41 ?  285 LEU A CG  1 
ATOM   1989 C CD1 . LEU A 1 285 ? 137.662 109.221 83.968  1.00 194.56 ?  285 LEU A CD1 1 
ATOM   1990 C CD2 . LEU A 1 285 ? 139.108 107.199 83.682  1.00 196.13 ?  285 LEU A CD2 1 
ATOM   1991 N N   . ARG A 1 286 ? 133.902 107.053 84.316  1.00 198.42 ?  286 ARG A N   1 
ATOM   1992 C CA  . ARG A 1 286 ? 132.802 107.396 83.418  1.00 199.80 ?  286 ARG A CA  1 
ATOM   1993 C C   . ARG A 1 286 ? 131.828 108.362 84.080  1.00 198.97 ?  286 ARG A C   1 
ATOM   1994 O O   . ARG A 1 286 ? 131.442 109.375 83.483  1.00 197.97 ?  286 ARG A O   1 
ATOM   1995 C CB  . ARG A 1 286 ? 132.069 106.128 82.981  1.00 201.38 ?  286 ARG A CB  1 
ATOM   1996 N N   . ALA A 1 287 ? 131.423 108.067 85.316  1.00 190.97 ?  287 ALA A N   1 
ATOM   1997 C CA  . ALA A 1 287 ? 130.480 108.928 86.020  1.00 190.26 ?  287 ALA A CA  1 
ATOM   1998 C C   . ALA A 1 287 ? 131.084 110.299 86.289  1.00 190.07 ?  287 ALA A C   1 
ATOM   1999 O O   . ALA A 1 287 ? 130.400 111.324 86.175  1.00 190.46 ?  287 ALA A O   1 
ATOM   2000 C CB  . ALA A 1 287 ? 130.039 108.267 87.326  1.00 189.06 ?  287 ALA A CB  1 
ATOM   2001 N N   . LEU A 1 288 ? 132.366 110.337 86.661  1.00 193.46 ?  288 LEU A N   1 
ATOM   2002 C CA  . LEU A 1 288 ? 133.019 111.615 86.924  1.00 194.83 ?  288 LEU A CA  1 
ATOM   2003 C C   . LEU A 1 288 ? 133.114 112.457 85.657  1.00 195.47 ?  288 LEU A C   1 
ATOM   2004 O O   . LEU A 1 288 ? 132.881 113.671 85.690  1.00 197.30 ?  288 LEU A O   1 
ATOM   2005 C CB  . LEU A 1 288 ? 134.397 111.378 87.539  1.00 192.12 ?  288 LEU A CB  1 
ATOM   2006 C CG  . LEU A 1 288 ? 134.321 110.976 89.014  1.00 191.88 ?  288 LEU A CG  1 
ATOM   2007 C CD1 . LEU A 1 288 ? 135.686 110.617 89.567  1.00 194.57 ?  288 LEU A CD1 1 
ATOM   2008 C CD2 . LEU A 1 288 ? 133.693 112.094 89.828  1.00 189.24 ?  288 LEU A CD2 1 
ATOM   2009 N N   . GLN A 1 289 ? 133.433 111.831 84.524  1.00 190.67 ?  289 GLN A N   1 
ATOM   2010 C CA  . GLN A 1 289 ? 133.446 112.567 83.265  1.00 188.91 ?  289 GLN A CA  1 
ATOM   2011 C C   . GLN A 1 289 ? 132.050 113.047 82.892  1.00 190.76 ?  289 GLN A C   1 
ATOM   2012 O O   . GLN A 1 289 ? 131.891 114.147 82.350  1.00 190.21 ?  289 GLN A O   1 
ATOM   2013 C CB  . GLN A 1 289 ? 134.035 111.704 82.152  1.00 187.14 ?  289 GLN A CB  1 
ATOM   2014 C CG  . GLN A 1 289 ? 135.543 111.568 82.214  1.00 189.11 ?  289 GLN A CG  1 
ATOM   2015 C CD  . GLN A 1 289 ? 136.098 110.729 81.083  1.00 192.23 ?  289 GLN A CD  1 
ATOM   2016 O OE1 . GLN A 1 289 ? 135.355 110.040 80.384  1.00 193.18 ?  289 GLN A OE1 1 
ATOM   2017 N NE2 . GLN A 1 289 ? 137.411 110.784 80.894  1.00 191.34 ?  289 GLN A NE2 1 
ATOM   2018 N N   . ARG A 1 290 ? 131.025 112.236 83.166  1.00 191.74 ?  290 ARG A N   1 
ATOM   2019 C CA  . ARG A 1 290 ? 129.662 112.644 82.841  1.00 191.55 ?  290 ARG A CA  1 
ATOM   2020 C C   . ARG A 1 290 ? 129.234 113.852 83.667  1.00 190.83 ?  290 ARG A C   1 
ATOM   2021 O O   . ARG A 1 290 ? 128.655 114.807 83.131  1.00 192.82 ?  290 ARG A O   1 
ATOM   2022 C CB  . ARG A 1 290 ? 128.700 111.475 83.052  1.00 189.58 ?  290 ARG A CB  1 
ATOM   2023 C CG  . ARG A 1 290 ? 127.388 111.602 82.294  1.00 187.25 ?  290 ARG A CG  1 
ATOM   2024 C CD  . ARG A 1 290 ? 126.519 110.373 82.497  1.00 188.12 ?  290 ARG A CD  1 
ATOM   2025 N NE  . ARG A 1 290 ? 127.091 109.185 81.877  1.00 193.37 ?  290 ARG A NE  1 
ATOM   2026 C CZ  . ARG A 1 290 ? 126.560 107.972 81.951  1.00 193.55 ?  290 ARG A CZ  1 
ATOM   2027 N NH1 . ARG A 1 290 ? 125.442 107.748 82.621  1.00 189.77 1  290 ARG A NH1 1 
ATOM   2028 N NH2 . ARG A 1 290 ? 127.168 106.959 81.342  1.00 194.27 ?  290 ARG A NH2 1 
ATOM   2029 N N   . VAL A 1 291 ? 129.513 113.835 84.973  1.00 175.55 ?  291 VAL A N   1 
ATOM   2030 C CA  . VAL A 1 291 ? 129.153 114.983 85.802  1.00 174.64 ?  291 VAL A CA  1 
ATOM   2031 C C   . VAL A 1 291 ? 129.988 116.198 85.415  1.00 175.95 ?  291 VAL A C   1 
ATOM   2032 O O   . VAL A 1 291 ? 129.511 117.336 85.472  1.00 178.68 ?  291 VAL A O   1 
ATOM   2033 C CB  . VAL A 1 291 ? 129.267 114.654 87.305  1.00 171.84 ?  291 VAL A CB  1 
ATOM   2034 C CG1 . VAL A 1 291 ? 130.598 114.057 87.637  1.00 176.41 ?  291 VAL A CG1 1 
ATOM   2035 C CG2 . VAL A 1 291 ? 129.046 115.900 88.147  1.00 171.76 ?  291 VAL A CG2 1 
ATOM   2036 N N   . ALA A 1 292 ? 131.205 115.954 84.952  1.00 182.72 ?  292 ALA A N   1 
ATOM   2037 C CA  . ALA A 1 292 ? 132.066 117.050 84.539  1.00 183.19 ?  292 ALA A CA  1 
ATOM   2038 C C   . ALA A 1 292 ? 131.380 117.921 83.509  1.00 183.97 ?  292 ALA A C   1 
ATOM   2039 O O   . ALA A 1 292 ? 131.061 119.077 83.777  1.00 183.11 ?  292 ALA A O   1 
ATOM   2040 C CB  . ALA A 1 292 ? 133.366 116.508 83.979  1.00 184.40 ?  292 ALA A CB  1 
ATOM   2041 N N   . ARG A 1 293 ? 131.145 117.369 82.327  1.00 191.74 ?  293 ARG A N   1 
ATOM   2042 C CA  . ARG A 1 293 ? 130.542 118.155 81.262  1.00 192.15 ?  293 ARG A CA  1 
ATOM   2043 C C   . ARG A 1 293 ? 129.224 118.736 81.724  1.00 192.43 ?  293 ARG A C   1 
ATOM   2044 O O   . ARG A 1 293 ? 128.947 119.910 81.501  1.00 192.50 ?  293 ARG A O   1 
ATOM   2045 C CB  . ARG A 1 293 ? 130.326 117.296 80.017  1.00 190.29 ?  293 ARG A CB  1 
ATOM   2046 N N   . ILE A 1 294 ? 128.408 117.913 82.370  1.00 174.96 ?  294 ILE A N   1 
ATOM   2047 C CA  . ILE A 1 294 ? 127.137 118.395 82.869  1.00 171.32 ?  294 ILE A CA  1 
ATOM   2048 C C   . ILE A 1 294 ? 127.372 119.703 83.586  1.00 172.85 ?  294 ILE A C   1 
ATOM   2049 O O   . ILE A 1 294 ? 126.683 120.687 83.334  1.00 175.83 ?  294 ILE A O   1 
ATOM   2050 C CB  . ILE A 1 294 ? 126.487 117.407 83.842  1.00 168.98 ?  294 ILE A CB  1 
ATOM   2051 C CG1 . ILE A 1 294 ? 126.045 116.144 83.110  1.00 171.44 ?  294 ILE A CG1 1 
ATOM   2052 C CG2 . ILE A 1 294 ? 125.289 118.049 84.518  1.00 173.00 ?  294 ILE A CG2 1 
ATOM   2053 C CD1 . ILE A 1 294 ? 125.462 115.091 84.026  1.00 174.89 ?  294 ILE A CD1 1 
ATOM   2054 N N   . ASN A 1 295 ? 128.353 119.723 84.477  1.00 176.35 ?  295 ASN A N   1 
ATOM   2055 C CA  . ASN A 1 295 ? 128.613 120.925 85.252  1.00 176.72 ?  295 ASN A CA  1 
ATOM   2056 C C   . ASN A 1 295 ? 129.379 121.968 84.447  1.00 177.98 ?  295 ASN A C   1 
ATOM   2057 O O   . ASN A 1 295 ? 129.663 123.049 84.959  1.00 178.33 ?  295 ASN A O   1 
ATOM   2058 C CB  . ASN A 1 295 ? 129.385 120.586 86.529  1.00 178.18 ?  295 ASN A CB  1 
ATOM   2059 C CG  . ASN A 1 295 ? 128.535 119.859 87.548  1.00 175.97 ?  295 ASN A CG  1 
ATOM   2060 O OD1 . ASN A 1 295 ? 127.315 119.774 87.409  1.00 174.38 ?  295 ASN A OD1 1 
ATOM   2061 N ND2 . ASN A 1 295 ? 129.175 119.336 88.587  1.00 176.72 ?  295 ASN A ND2 1 
ATOM   2062 N N   . GLY A 1 296 ? 129.715 121.668 83.195  1.00 191.95 ?  296 GLY A N   1 
ATOM   2063 C CA  . GLY A 1 296 ? 130.387 122.679 82.409  1.00 193.25 ?  296 GLY A CA  1 
ATOM   2064 C C   . GLY A 1 296 ? 131.890 122.727 82.577  1.00 193.97 ?  296 GLY A C   1 
ATOM   2065 O O   . GLY A 1 296 ? 132.568 123.354 81.754  1.00 193.55 ?  296 GLY A O   1 
ATOM   2066 N N   . LYS A 1 297 ? 132.411 122.099 83.625  1.00 201.86 ?  297 LYS A N   1 
ATOM   2067 C CA  . LYS A 1 297 ? 133.849 122.076 83.861  1.00 202.37 ?  297 LYS A CA  1 
ATOM   2068 C C   . LYS A 1 297 ? 134.476 120.855 83.215  1.00 203.10 ?  297 LYS A C   1 
ATOM   2069 O O   . LYS A 1 297 ? 135.079 120.029 83.898  1.00 203.10 ?  297 LYS A O   1 
ATOM   2070 C CB  . LYS A 1 297 ? 134.136 122.079 85.360  1.00 202.29 ?  297 LYS A CB  1 
ATOM   2071 C CG  . LYS A 1 297 ? 133.649 123.324 86.079  1.00 200.18 ?  297 LYS A CG  1 
ATOM   2072 C CD  . LYS A 1 297 ? 133.842 123.199 87.581  1.00 200.42 ?  297 LYS A CD  1 
ATOM   2073 C CE  . LYS A 1 297 ? 135.279 122.851 87.930  1.00 202.35 ?  297 LYS A CE  1 
ATOM   2074 N NZ  . LYS A 1 297 ? 136.233 123.899 87.473  1.00 204.00 1  297 LYS A NZ  1 
ATOM   2075 N N   . ARG A 1 298 ? 134.344 120.736 81.899  1.00 208.17 ?  298 ARG A N   1 
ATOM   2076 C CA  . ARG A 1 298 ? 134.859 119.559 81.201  1.00 207.57 ?  298 ARG A CA  1 
ATOM   2077 C C   . ARG A 1 298 ? 136.371 119.439 81.268  1.00 207.80 ?  298 ARG A C   1 
ATOM   2078 O O   . ARG A 1 298 ? 136.893 118.400 81.669  1.00 208.13 ?  298 ARG A O   1 
ATOM   2079 C CB  . ARG A 1 298 ? 134.420 119.582 79.734  1.00 205.96 ?  298 ARG A CB  1 
ATOM   2080 N N   . GLU A 1 299 ? 137.079 120.488 80.870  1.00 216.61 ?  299 GLU A N   1 
ATOM   2081 C CA  . GLU A 1 299 ? 138.537 120.428 80.831  1.00 217.72 ?  299 GLU A CA  1 
ATOM   2082 C C   . GLU A 1 299 ? 139.089 119.748 82.062  1.00 216.68 ?  299 GLU A C   1 
ATOM   2083 O O   . GLU A 1 299 ? 140.102 119.053 81.995  1.00 216.41 ?  299 GLU A O   1 
ATOM   2084 C CB  . GLU A 1 299 ? 139.115 121.838 80.710  1.00 217.68 ?  299 GLU A CB  1 
ATOM   2085 C CG  . GLU A 1 299 ? 140.633 121.909 80.779  1.00 217.28 ?  299 GLU A CG  1 
ATOM   2086 C CD  . GLU A 1 299 ? 141.154 121.949 82.202  1.00 217.88 ?  299 GLU A CD  1 
ATOM   2087 O OE1 . GLU A 1 299 ? 142.367 121.732 82.399  1.00 216.95 ?  299 GLU A OE1 1 
ATOM   2088 O OE2 . GLU A 1 299 ? 140.349 122.194 83.123  1.00 218.48 -1 299 GLU A OE2 1 
ATOM   2089 N N   . GLU A 1 300 ? 138.421 119.934 83.189  1.00 208.19 ?  300 GLU A N   1 
ATOM   2090 C CA  . GLU A 1 300 ? 138.915 119.383 84.436  1.00 209.38 ?  300 GLU A CA  1 
ATOM   2091 C C   . GLU A 1 300 ? 138.715 117.888 84.398  1.00 209.02 ?  300 GLU A C   1 
ATOM   2092 O O   . GLU A 1 300 ? 139.657 117.120 84.584  1.00 209.72 ?  300 GLU A O   1 
ATOM   2093 C CB  . GLU A 1 300 ? 138.178 119.989 85.625  1.00 208.65 ?  300 GLU A CB  1 
ATOM   2094 C CG  . GLU A 1 300 ? 138.278 121.501 85.712  1.00 208.02 ?  300 GLU A CG  1 
ATOM   2095 C CD  . GLU A 1 300 ? 139.690 121.979 85.986  1.00 209.48 ?  300 GLU A CD  1 
ATOM   2096 O OE1 . GLU A 1 300 ? 140.558 121.139 86.302  1.00 210.28 ?  300 GLU A OE1 1 
ATOM   2097 O OE2 . GLU A 1 300 ? 139.931 123.200 85.890  1.00 210.15 -1 300 GLU A OE2 1 
ATOM   2098 N N   . GLY A 1 301 ? 137.484 117.471 84.142  1.00 200.23 ?  301 GLY A N   1 
ATOM   2099 C CA  . GLY A 1 301 ? 137.195 116.056 84.063  1.00 199.74 ?  301 GLY A CA  1 
ATOM   2100 C C   . GLY A 1 301 ? 138.095 115.387 83.051  1.00 200.39 ?  301 GLY A C   1 
ATOM   2101 O O   . GLY A 1 301 ? 138.755 114.400 83.356  1.00 200.27 ?  301 GLY A O   1 
ATOM   2102 N N   . ALA A 1 302 ? 138.121 115.922 81.835  1.00 204.81 ?  302 ALA A N   1 
ATOM   2103 C CA  . ALA A 1 302 ? 138.945 115.318 80.794  1.00 205.20 ?  302 ALA A CA  1 
ATOM   2104 C C   . ALA A 1 302 ? 140.357 115.051 81.298  1.00 205.07 ?  302 ALA A C   1 
ATOM   2105 O O   . ALA A 1 302 ? 140.959 114.022 80.969  1.00 204.66 ?  302 ALA A O   1 
ATOM   2106 C CB  . ALA A 1 302 ? 138.975 116.218 79.559  1.00 204.56 ?  302 ALA A CB  1 
ATOM   2107 N N   . LYS A 1 303 ? 140.905 115.974 82.092  1.00 203.74 ?  303 LYS A N   1 
ATOM   2108 C CA  . LYS A 1 303 ? 142.220 115.751 82.686  1.00 203.55 ?  303 LYS A CA  1 
ATOM   2109 C C   . LYS A 1 303 ? 142.196 114.572 83.650  1.00 203.65 ?  303 LYS A C   1 
ATOM   2110 O O   . LYS A 1 303 ? 143.172 113.819 83.748  1.00 203.31 ?  303 LYS A O   1 
ATOM   2111 C CB  . LYS A 1 303 ? 142.697 117.020 83.398  1.00 201.65 ?  303 LYS A CB  1 
ATOM   2112 C CG  . LYS A 1 303 ? 144.190 117.068 83.782  1.00 201.73 ?  303 LYS A CG  1 
ATOM   2113 C CD  . LYS A 1 303 ? 145.207 116.564 82.736  1.00 203.16 ?  303 LYS A CD  1 
ATOM   2114 C CE  . LYS A 1 303 ? 144.918 116.996 81.296  1.00 202.43 ?  303 LYS A CE  1 
ATOM   2115 N NZ  . LYS A 1 303 ? 145.901 116.415 80.342  1.00 201.23 1  303 LYS A NZ  1 
ATOM   2116 N N   . LEU A 1 304 ? 141.091 114.396 84.368  1.00 207.92 ?  304 LEU A N   1 
ATOM   2117 C CA  . LEU A 1 304 ? 140.968 113.294 85.312  1.00 207.18 ?  304 LEU A CA  1 
ATOM   2118 C C   . LEU A 1 304 ? 140.942 111.962 84.574  1.00 208.83 ?  304 LEU A C   1 
ATOM   2119 O O   . LEU A 1 304 ? 139.972 111.646 83.879  1.00 209.16 ?  304 LEU A O   1 
ATOM   2120 C CB  . LEU A 1 304 ? 139.701 113.474 86.146  1.00 207.63 ?  304 LEU A CB  1 
ATOM   2121 C CG  . LEU A 1 304 ? 139.344 112.361 87.128  1.00 208.91 ?  304 LEU A CG  1 
ATOM   2122 C CD1 . LEU A 1 304 ? 140.453 112.172 88.146  1.00 208.27 ?  304 LEU A CD1 1 
ATOM   2123 C CD2 . LEU A 1 304 ? 138.037 112.690 87.818  1.00 208.68 ?  304 LEU A CD2 1 
ATOM   2124 N N   . SER A 1 305 ? 142.010 111.181 84.728  1.00 222.81 ?  305 SER A N   1 
ATOM   2125 C CA  . SER A 1 305 ? 142.116 109.892 84.057  1.00 223.46 ?  305 SER A CA  1 
ATOM   2126 C C   . SER A 1 305 ? 142.250 108.761 85.069  1.00 224.12 ?  305 SER A C   1 
ATOM   2127 O O   . SER A 1 305 ? 142.139 108.987 86.278  1.00 225.12 ?  305 SER A O   1 
ATOM   2128 C CB  . SER A 1 305 ? 143.304 109.885 83.095  1.00 223.45 ?  305 SER A CB  1 
ATOM   2129 O OG  . SER A 1 305 ? 144.526 109.757 83.801  1.00 223.31 ?  305 SER A OG  1 
ATOM   2130 N N   . MET A 1 306 ? 142.491 107.541 84.583  1.00 224.66 ?  306 MET A N   1 
ATOM   2131 C CA  . MET A 1 306 ? 142.627 106.389 85.466  1.00 224.59 ?  306 MET A CA  1 
ATOM   2132 C C   . MET A 1 306 ? 143.805 106.517 86.423  1.00 224.14 ?  306 MET A C   1 
ATOM   2133 O O   . MET A 1 306 ? 143.668 106.167 87.600  1.00 225.34 ?  306 MET A O   1 
ATOM   2134 C CB  . MET A 1 306 ? 142.770 105.107 84.641  1.00 224.30 ?  306 MET A CB  1 
ATOM   2135 C CG  . MET A 1 306 ? 143.371 103.935 85.403  1.00 224.85 ?  306 MET A CG  1 
ATOM   2136 S SD  . MET A 1 306 ? 142.128 102.845 86.123  1.00 227.25 ?  306 MET A SD  1 
ATOM   2137 C CE  . MET A 1 306 ? 141.623 101.911 84.682  1.00 225.26 ?  306 MET A CE  1 
ATOM   2138 N N   . GLU A 1 307 ? 144.951 107.011 85.949  1.00 223.32 ?  307 GLU A N   1 
ATOM   2139 C CA  . GLU A 1 307 ? 146.107 107.168 86.825  1.00 224.99 ?  307 GLU A CA  1 
ATOM   2140 C C   . GLU A 1 307 ? 145.833 108.150 87.957  1.00 225.27 ?  307 GLU A C   1 
ATOM   2141 O O   . GLU A 1 307 ? 146.160 107.865 89.115  1.00 225.40 ?  307 GLU A O   1 
ATOM   2142 C CB  . GLU A 1 307 ? 147.319 107.624 86.013  1.00 225.21 ?  307 GLU A CB  1 
ATOM   2143 N N   . VAL A 1 308 ? 145.235 109.300 87.649  1.00 224.28 ?  308 VAL A N   1 
ATOM   2144 C CA  . VAL A 1 308 ? 144.919 110.278 88.684  1.00 224.79 ?  308 VAL A CA  1 
ATOM   2145 C C   . VAL A 1 308 ? 143.821 109.755 89.599  1.00 223.34 ?  308 VAL A C   1 
ATOM   2146 O O   . VAL A 1 308 ? 143.843 109.984 90.814  1.00 223.99 ?  308 VAL A O   1 
ATOM   2147 C CB  . VAL A 1 308 ? 144.528 111.624 88.047  1.00 224.75 ?  308 VAL A CB  1 
ATOM   2148 C CG1 . VAL A 1 308 ? 144.723 112.757 89.042  1.00 224.21 ?  308 VAL A CG1 1 
ATOM   2149 C CG2 . VAL A 1 308 ? 145.341 111.868 86.786  1.00 223.86 ?  308 VAL A CG2 1 
ATOM   2150 N N   . LEU A 1 309 ? 142.840 109.055 89.026  1.00 216.12 ?  309 LEU A N   1 
ATOM   2151 C CA  . LEU A 1 309 ? 141.752 108.510 89.829  1.00 215.88 ?  309 LEU A CA  1 
ATOM   2152 C C   . LEU A 1 309 ? 142.269 107.496 90.842  1.00 217.42 ?  309 LEU A C   1 
ATOM   2153 O O   . LEU A 1 309 ? 141.878 107.524 92.014  1.00 217.50 ?  309 LEU A O   1 
ATOM   2154 C CB  . LEU A 1 309 ? 140.699 107.878 88.919  1.00 216.83 ?  309 LEU A CB  1 
ATOM   2155 C CG  . LEU A 1 309 ? 139.465 107.278 89.590  1.00 218.21 ?  309 LEU A CG  1 
ATOM   2156 C CD1 . LEU A 1 309 ? 138.689 108.354 90.329  1.00 218.51 ?  309 LEU A CD1 1 
ATOM   2157 C CD2 . LEU A 1 309 ? 138.583 106.587 88.561  1.00 217.60 ?  309 LEU A CD2 1 
ATOM   2158 N N   . ARG A 1 310 ? 143.158 106.599 90.412  1.00 222.74 ?  310 ARG A N   1 
ATOM   2159 C CA  . ARG A 1 310 ? 143.744 105.629 91.330  1.00 223.49 ?  310 ARG A CA  1 
ATOM   2160 C C   . ARG A 1 310 ? 144.596 106.323 92.386  1.00 224.17 ?  310 ARG A C   1 
ATOM   2161 O O   . ARG A 1 310 ? 144.572 105.954 93.566  1.00 225.61 ?  310 ARG A O   1 
ATOM   2162 C CB  . ARG A 1 310 ? 144.576 104.606 90.554  1.00 221.79 ?  310 ARG A CB  1 
ATOM   2163 C CG  . ARG A 1 310 ? 143.773 103.727 89.611  1.00 222.21 ?  310 ARG A CG  1 
ATOM   2164 C CD  . ARG A 1 310 ? 144.687 102.812 88.812  1.00 222.41 ?  310 ARG A CD  1 
ATOM   2165 N NE  . ARG A 1 310 ? 145.398 101.865 89.663  1.00 223.68 ?  310 ARG A NE  1 
ATOM   2166 C CZ  . ARG A 1 310 ? 146.339 101.035 89.233  1.00 223.79 ?  310 ARG A CZ  1 
ATOM   2167 N NH1 . ARG A 1 310 ? 146.712 101.010 87.964  1.00 223.81 1  310 ARG A NH1 1 
ATOM   2168 N NH2 . ARG A 1 310 ? 146.920 100.210 90.099  1.00 223.30 ?  310 ARG A NH2 1 
ATOM   2169 N N   . ALA A 1 311 ? 145.369 107.330 91.972  1.00 214.67 ?  311 ALA A N   1 
ATOM   2170 C CA  . ALA A 1 311 ? 146.245 108.028 92.908  1.00 213.81 ?  311 ALA A CA  1 
ATOM   2171 C C   . ALA A 1 311 ? 145.449 108.737 93.995  1.00 214.33 ?  311 ALA A C   1 
ATOM   2172 O O   . ALA A 1 311 ? 145.804 108.674 95.178  1.00 213.22 ?  311 ALA A O   1 
ATOM   2173 C CB  . ALA A 1 311 ? 147.128 109.024 92.156  1.00 213.42 ?  311 ALA A CB  1 
ATOM   2174 N N   . SER A 1 312 ? 144.367 109.412 93.617  1.00 216.75 ?  312 SER A N   1 
ATOM   2175 C CA  . SER A 1 312 ? 143.546 110.135 94.579  1.00 216.41 ?  312 SER A CA  1 
ATOM   2176 C C   . SER A 1 312 ? 142.489 109.259 95.238  1.00 214.99 ?  312 SER A C   1 
ATOM   2177 O O   . SER A 1 312 ? 141.782 109.738 96.130  1.00 214.44 ?  312 SER A O   1 
ATOM   2178 C CB  . SER A 1 312 ? 142.873 111.329 93.901  1.00 215.26 ?  312 SER A CB  1 
ATOM   2179 O OG  . SER A 1 312 ? 143.836 112.253 93.427  1.00 215.43 ?  312 SER A OG  1 
ATOM   2180 N N   . LEU A 1 313 ? 142.362 107.997 94.828  1.00 211.31 ?  313 LEU A N   1 
ATOM   2181 C CA  . LEU A 1 313 ? 141.345 107.113 95.377  1.00 209.41 ?  313 LEU A CA  1 
ATOM   2182 C C   . LEU A 1 313 ? 141.936 105.869 96.030  1.00 212.17 ?  313 LEU A C   1 
ATOM   2183 O O   . LEU A 1 313 ? 141.186 104.949 96.371  1.00 212.36 ?  313 LEU A O   1 
ATOM   2184 C CB  . LEU A 1 313 ? 140.351 106.707 94.282  1.00 209.64 ?  313 LEU A CB  1 
ATOM   2185 C CG  . LEU A 1 313 ? 138.903 106.469 94.710  1.00 212.82 ?  313 LEU A CG  1 
ATOM   2186 C CD1 . LEU A 1 313 ? 138.453 107.544 95.681  1.00 213.40 ?  313 LEU A CD1 1 
ATOM   2187 C CD2 . LEU A 1 313 ? 137.997 106.436 93.493  1.00 214.92 ?  313 LEU A CD2 1 
ATOM   2188 N N   . GLN A 1 314 ? 143.255 105.818 96.225  1.00 223.08 ?  314 GLN A N   1 
ATOM   2189 C CA  . GLN A 1 314 ? 143.869 104.615 96.778  1.00 224.17 ?  314 GLN A CA  1 
ATOM   2190 C C   . GLN A 1 314 ? 143.618 104.490 98.278  1.00 223.67 ?  314 GLN A C   1 
ATOM   2191 O O   . GLN A 1 314 ? 143.389 103.385 98.783  1.00 221.77 ?  314 GLN A O   1 
ATOM   2192 C CB  . GLN A 1 314 ? 145.369 104.612 96.481  1.00 222.49 ?  314 GLN A CB  1 
ATOM   2193 N N   . LYS A 1 315 ? 143.657 105.611 99.005  1.00 217.44 ?  315 LYS A N   1 
ATOM   2194 C CA  . LYS A 1 315 ? 143.621 105.552 100.465 1.00 216.66 ?  315 LYS A CA  1 
ATOM   2195 C C   . LYS A 1 315 ? 142.310 104.966 100.979 1.00 216.40 ?  315 LYS A C   1 
ATOM   2196 O O   . LYS A 1 315 ? 142.315 104.122 101.883 1.00 214.14 ?  315 LYS A O   1 
ATOM   2197 C CB  . LYS A 1 315 ? 143.853 106.943 101.051 1.00 215.23 ?  315 LYS A CB  1 
ATOM   2198 N N   . GLU A 1 316 ? 141.177 105.400 100.423 1.00 216.08 ?  316 GLU A N   1 
ATOM   2199 C CA  . GLU A 1 316 ? 139.894 104.850 100.854 1.00 214.70 ?  316 GLU A CA  1 
ATOM   2200 C C   . GLU A 1 316 ? 139.789 103.369 100.515 1.00 214.33 ?  316 GLU A C   1 
ATOM   2201 O O   . GLU A 1 316 ? 139.193 102.593 101.271 1.00 214.46 ?  316 GLU A O   1 
ATOM   2202 C CB  . GLU A 1 316 ? 138.729 105.628 100.232 1.00 212.92 ?  316 GLU A CB  1 
ATOM   2203 C CG  . GLU A 1 316 ? 138.917 107.142 100.095 1.00 212.88 ?  316 GLU A CG  1 
ATOM   2204 C CD  . GLU A 1 316 ? 139.800 107.543 98.930  1.00 214.50 ?  316 GLU A CD  1 
ATOM   2205 O OE1 . GLU A 1 316 ? 139.735 108.716 98.506  1.00 215.30 ?  316 GLU A OE1 1 
ATOM   2206 O OE2 . GLU A 1 316 ? 140.567 106.691 98.446  1.00 214.74 -1 316 GLU A OE2 1 
ATOM   2207 N N   . LEU A 1 317 ? 140.354 102.959 99.384  1.00 207.27 ?  317 LEU A N   1 
ATOM   2208 C CA  . LEU A 1 317 ? 140.363 101.549 99.016  1.00 207.13 ?  317 LEU A CA  1 
ATOM   2209 C C   . LEU A 1 317 ? 141.370 100.777 99.863  1.00 206.23 ?  317 LEU A C   1 
ATOM   2210 O O   . LEU A 1 317 ? 141.044 99.740  100.440 1.00 205.46 ?  317 LEU A O   1 
ATOM   2211 C CB  . LEU A 1 317 ? 140.685 101.374 97.531  1.00 206.99 ?  317 LEU A CB  1 
ATOM   2212 C CG  . LEU A 1 317 ? 139.711 102.014 96.541  1.00 206.21 ?  317 LEU A CG  1 
ATOM   2213 C CD1 . LEU A 1 317 ? 140.359 102.181 95.173  1.00 204.50 ?  317 LEU A CD1 1 
ATOM   2214 C CD2 . LEU A 1 317 ? 138.439 101.195 96.444  1.00 205.30 ?  317 LEU A CD2 1 
ATOM   2215 N N   . GLN A 1 323 ? 133.931 99.425  107.958 1.00 209.94 ?  323 GLN A N   1 
ATOM   2216 C CA  . GLN A 1 323 ? 132.922 99.277  108.999 1.00 210.24 ?  323 GLN A CA  1 
ATOM   2217 C C   . GLN A 1 323 ? 132.943 97.870  109.584 1.00 211.26 ?  323 GLN A C   1 
ATOM   2218 O O   . GLN A 1 323 ? 133.050 96.886  108.853 1.00 212.36 ?  323 GLN A O   1 
ATOM   2219 C CB  . GLN A 1 323 ? 131.534 99.598  108.449 1.00 209.18 ?  323 GLN A CB  1 
ATOM   2220 C CG  . GLN A 1 323 ? 131.330 101.064 108.109 1.00 209.17 ?  323 GLN A CG  1 
ATOM   2221 C CD  . GLN A 1 323 ? 130.133 101.289 107.209 1.00 210.83 ?  323 GLN A CD  1 
ATOM   2222 O OE1 . GLN A 1 323 ? 129.186 100.502 107.209 1.00 212.44 ?  323 GLN A OE1 1 
ATOM   2223 N NE2 . GLN A 1 323 ? 130.167 102.368 106.436 1.00 209.44 ?  323 GLN A NE2 1 
ATOM   2224 N N   . ALA A 1 324 ? 132.837 97.781  110.905 1.00 210.25 ?  324 ALA A N   1 
ATOM   2225 C CA  . ALA A 1 324 ? 132.867 96.498  111.586 1.00 208.92 ?  324 ALA A CA  1 
ATOM   2226 C C   . ALA A 1 324 ? 131.488 95.846  111.566 1.00 208.85 ?  324 ALA A C   1 
ATOM   2227 O O   . ALA A 1 324 ? 130.490 96.444  111.157 1.00 208.22 ?  324 ALA A O   1 
ATOM   2228 C CB  . ALA A 1 324 ? 133.361 96.664  113.023 1.00 208.46 ?  324 ALA A CB  1 
ATOM   2229 N N   . SER A 1 325 ? 131.446 94.596  112.013 1.00 204.82 ?  325 SER A N   1 
ATOM   2230 C CA  . SER A 1 325 ? 130.208 93.838  112.045 1.00 205.35 ?  325 SER A CA  1 
ATOM   2231 C C   . SER A 1 325 ? 129.304 94.324  113.173 1.00 205.73 ?  325 SER A C   1 
ATOM   2232 O O   . SER A 1 325 ? 129.760 94.831  114.202 1.00 206.12 ?  325 SER A O   1 
ATOM   2233 C CB  . SER A 1 325 ? 130.495 92.347  112.218 1.00 203.92 ?  325 SER A CB  1 
ATOM   2234 O OG  . SER A 1 325 ? 131.173 92.101  113.438 1.00 201.12 ?  325 SER A OG  1 
ATOM   2235 N N   . ALA A 1 326 ? 127.997 94.152  112.966 1.00 193.33 ?  326 ALA A N   1 
ATOM   2236 C CA  . ALA A 1 326 ? 127.026 94.513  113.991 1.00 189.91 ?  326 ALA A CA  1 
ATOM   2237 C C   . ALA A 1 326 ? 127.181 93.671  115.248 1.00 191.47 ?  326 ALA A C   1 
ATOM   2238 O O   . ALA A 1 326 ? 126.740 94.094  116.321 1.00 192.15 ?  326 ALA A O   1 
ATOM   2239 C CB  . ALA A 1 326 ? 125.607 94.376  113.441 1.00 189.31 ?  326 ALA A CB  1 
ATOM   2240 N N   . MET A 1 327 ? 127.794 92.490  115.138 1.00 199.49 ?  327 MET A N   1 
ATOM   2241 C CA  . MET A 1 327 ? 128.063 91.670  116.314 1.00 200.47 ?  327 MET A CA  1 
ATOM   2242 C C   . MET A 1 327 ? 128.983 92.391  117.293 1.00 201.18 ?  327 MET A C   1 
ATOM   2243 O O   . MET A 1 327 ? 128.873 92.194  118.510 1.00 200.09 ?  327 MET A O   1 
ATOM   2244 C CB  . MET A 1 327 ? 128.653 90.327  115.864 1.00 199.56 ?  327 MET A CB  1 
ATOM   2245 C CG  . MET A 1 327 ? 128.979 89.302  116.951 1.00 199.38 ?  327 MET A CG  1 
ATOM   2246 S SD  . MET A 1 327 ? 130.458 89.623  117.934 1.00 199.31 ?  327 MET A SD  1 
ATOM   2247 C CE  . MET A 1 327 ? 131.611 88.477  117.183 1.00 198.96 ?  327 MET A CE  1 
ATOM   2248 N N   . GLU A 1 328 ? 129.880 93.238  116.782 1.00 206.34 ?  328 GLU A N   1 
ATOM   2249 C CA  . GLU A 1 328 ? 130.773 93.992  117.656 1.00 205.21 ?  328 GLU A CA  1 
ATOM   2250 C C   . GLU A 1 328 ? 129.991 94.898  118.596 1.00 205.07 ?  328 GLU A C   1 
ATOM   2251 O O   . GLU A 1 328 ? 130.447 95.193  119.706 1.00 205.66 ?  328 GLU A O   1 
ATOM   2252 C CB  . GLU A 1 328 ? 131.756 94.813  116.822 1.00 204.72 ?  328 GLU A CB  1 
ATOM   2253 C CG  . GLU A 1 328 ? 132.764 93.980  116.052 1.00 205.95 ?  328 GLU A CG  1 
ATOM   2254 C CD  . GLU A 1 328 ? 134.176 94.518  116.173 1.00 207.01 ?  328 GLU A CD  1 
ATOM   2255 O OE1 . GLU A 1 328 ? 134.340 95.756  116.191 1.00 207.21 ?  328 GLU A OE1 1 
ATOM   2256 O OE2 . GLU A 1 328 ? 135.122 93.706  116.244 1.00 206.95 -1 328 GLU A OE2 1 
ATOM   2257 N N   . LEU A 1 329 ? 128.811 95.351  118.168 1.00 191.14 ?  329 LEU A N   1 
ATOM   2258 C CA  . LEU A 1 329 ? 127.990 96.202  119.023 1.00 190.95 ?  329 LEU A CA  1 
ATOM   2259 C C   . LEU A 1 329 ? 127.555 95.457  120.278 1.00 191.09 ?  329 LEU A C   1 
ATOM   2260 O O   . LEU A 1 329 ? 127.553 96.019  121.379 1.00 193.33 ?  329 LEU A O   1 
ATOM   2261 C CB  . LEU A 1 329 ? 126.777 96.710  118.245 1.00 190.11 ?  329 LEU A CB  1 
ATOM   2262 C CG  . LEU A 1 329 ? 127.075 97.787  117.201 1.00 188.70 ?  329 LEU A CG  1 
ATOM   2263 C CD1 . LEU A 1 329 ? 125.950 97.880  116.187 1.00 189.62 ?  329 LEU A CD1 1 
ATOM   2264 C CD2 . LEU A 1 329 ? 127.311 99.129  117.868 1.00 188.23 ?  329 LEU A CD2 1 
ATOM   2265 N N   . LEU A 1 330 ? 127.178 94.185  120.133 1.00 182.18 ?  330 LEU A N   1 
ATOM   2266 C CA  . LEU A 1 330 ? 126.809 93.392  121.300 1.00 181.83 ?  330 LEU A CA  1 
ATOM   2267 C C   . LEU A 1 330 ? 128.038 92.941  122.080 1.00 185.29 ?  330 LEU A C   1 
ATOM   2268 O O   . LEU A 1 330 ? 128.002 92.863  123.314 1.00 184.74 ?  330 LEU A O   1 
ATOM   2269 C CB  . LEU A 1 330 ? 125.975 92.181  120.878 1.00 183.91 ?  330 LEU A CB  1 
ATOM   2270 C CG  . LEU A 1 330 ? 124.621 92.381  120.192 1.00 185.81 ?  330 LEU A CG  1 
ATOM   2271 C CD1 . LEU A 1 330 ? 123.658 91.284  120.613 1.00 186.76 ?  330 LEU A CD1 1 
ATOM   2272 C CD2 . LEU A 1 330 ? 124.030 93.736  120.526 1.00 183.48 ?  330 LEU A CD2 1 
ATOM   2273 N N   . ARG A 1 331 ? 129.132 92.635  121.380 1.00 198.91 ?  331 ARG A N   1 
ATOM   2274 C CA  . ARG A 1 331 ? 130.279 92.015  122.037 1.00 199.34 ?  331 ARG A CA  1 
ATOM   2275 C C   . ARG A 1 331 ? 131.005 92.993  122.955 1.00 199.28 ?  331 ARG A C   1 
ATOM   2276 O O   . ARG A 1 331 ? 131.302 92.672  124.111 1.00 198.09 ?  331 ARG A O   1 
ATOM   2277 C CB  . ARG A 1 331 ? 131.235 91.444  120.990 1.00 197.07 ?  331 ARG A CB  1 
ATOM   2278 N N   . CYS A 1 332 ? 131.299 94.194  122.460 1.00 204.72 ?  332 CYS A N   1 
ATOM   2279 C CA  . CYS A 1 332 ? 132.073 95.125  123.272 1.00 203.65 ?  332 CYS A CA  1 
ATOM   2280 C C   . CYS A 1 332 ? 131.186 95.758  124.342 1.00 203.33 ?  332 CYS A C   1 
ATOM   2281 O O   . CYS A 1 332 ? 130.199 96.421  124.014 1.00 204.15 ?  332 CYS A O   1 
ATOM   2282 C CB  . CYS A 1 332 ? 132.688 96.217  122.402 1.00 202.77 ?  332 CYS A CB  1 
ATOM   2283 S SG  . CYS A 1 332 ? 133.750 95.607  121.075 1.00 202.18 ?  332 CYS A SG  1 
ATOM   2284 N N   . PRO A 1 333 ? 131.519 95.575  125.623 1.00 209.90 ?  333 PRO A N   1 
ATOM   2285 C CA  . PRO A 1 333 ? 130.673 96.153  126.680 1.00 210.37 ?  333 PRO A CA  1 
ATOM   2286 C C   . PRO A 1 333 ? 130.557 97.664  126.598 1.00 210.82 ?  333 PRO A C   1 
ATOM   2287 O O   . PRO A 1 333 ? 129.466 98.202  126.832 1.00 211.27 ?  333 PRO A O   1 
ATOM   2288 C CB  . PRO A 1 333 ? 131.369 95.706  127.973 1.00 211.04 ?  333 PRO A CB  1 
ATOM   2289 C CG  . PRO A 1 333 ? 132.784 95.445  127.577 1.00 210.45 ?  333 PRO A CG  1 
ATOM   2290 C CD  . PRO A 1 333 ? 132.746 94.961  126.157 1.00 210.08 ?  333 PRO A CD  1 
ATOM   2291 N N   . THR A 1 334 ? 131.643 98.361  126.255 1.00 205.81 ?  334 THR A N   1 
ATOM   2292 C CA  . THR A 1 334 ? 131.565 99.806  126.078 1.00 205.40 ?  334 THR A CA  1 
ATOM   2293 C C   . THR A 1 334 ? 130.635 100.163 124.928 1.00 206.40 ?  334 THR A C   1 
ATOM   2294 O O   . THR A 1 334 ? 129.861 101.122 125.021 1.00 208.87 ?  334 THR A O   1 
ATOM   2295 C CB  . THR A 1 334 ? 132.958 100.386 125.841 1.00 206.53 ?  334 THR A CB  1 
ATOM   2296 O OG1 . THR A 1 334 ? 133.882 99.804  126.768 1.00 209.01 ?  334 THR A OG1 1 
ATOM   2297 C CG2 . THR A 1 334 ? 132.940 101.893 126.034 1.00 205.63 ?  334 THR A CG2 1 
ATOM   2298 N N   . LEU A 1 335 ? 130.699 99.405  123.835 1.00 194.23 ?  335 LEU A N   1 
ATOM   2299 C CA  . LEU A 1 335 ? 129.739 99.544  122.752 1.00 194.74 ?  335 LEU A CA  1 
ATOM   2300 C C   . LEU A 1 335 ? 128.375 98.965  123.093 1.00 195.42 ?  335 LEU A C   1 
ATOM   2301 O O   . LEU A 1 335 ? 127.368 99.476  122.598 1.00 193.14 ?  335 LEU A O   1 
ATOM   2302 C CB  . LEU A 1 335 ? 130.257 98.877  121.471 1.00 192.46 ?  335 LEU A CB  1 
ATOM   2303 C CG  . LEU A 1 335 ? 131.308 99.583  120.607 1.00 193.49 ?  335 LEU A CG  1 
ATOM   2304 C CD1 . LEU A 1 335 ? 130.711 100.847 120.010 1.00 192.28 ?  335 LEU A CD1 1 
ATOM   2305 C CD2 . LEU A 1 335 ? 132.600 99.888  121.354 1.00 194.17 ?  335 LEU A CD2 1 
ATOM   2306 N N   . ARG A 1 336 ? 128.315 97.915  123.914 1.00 197.12 ?  336 ARG A N   1 
ATOM   2307 C CA  . ARG A 1 336 ? 127.029 97.318  124.256 1.00 193.94 ?  336 ARG A CA  1 
ATOM   2308 C C   . ARG A 1 336 ? 126.162 98.277  125.059 1.00 193.17 ?  336 ARG A C   1 
ATOM   2309 O O   . ARG A 1 336 ? 124.955 98.379  124.813 1.00 195.29 ?  336 ARG A O   1 
ATOM   2310 C CB  . ARG A 1 336 ? 127.237 96.017  125.031 1.00 195.30 ?  336 ARG A CB  1 
ATOM   2311 C CG  . ARG A 1 336 ? 125.946 95.315  125.402 1.00 195.79 ?  336 ARG A CG  1 
ATOM   2312 C CD  . ARG A 1 336 ? 126.194 93.899  125.898 1.00 196.50 ?  336 ARG A CD  1 
ATOM   2313 N NE  . ARG A 1 336 ? 127.193 93.854  126.959 1.00 197.18 ?  336 ARG A NE  1 
ATOM   2314 C CZ  . ARG A 1 336 ? 127.899 92.777  127.278 1.00 196.81 ?  336 ARG A CZ  1 
ATOM   2315 N NH1 . ARG A 1 336 ? 127.745 91.633  126.632 1.00 195.57 1  336 ARG A NH1 1 
ATOM   2316 N NH2 . ARG A 1 336 ? 128.780 92.850  128.272 1.00 196.75 ?  336 ARG A NH2 1 
ATOM   2317 N N   . HIS A 1 337 ? 126.758 98.982  126.024 1.00 194.10 ?  337 HIS A N   1 
ATOM   2318 C CA  . HIS A 1 337 ? 126.000 99.957  126.802 1.00 194.42 ?  337 HIS A CA  1 
ATOM   2319 C C   . HIS A 1 337 ? 125.434 101.052 125.908 1.00 195.33 ?  337 HIS A C   1 
ATOM   2320 O O   . HIS A 1 337 ? 124.252 101.411 126.015 1.00 198.16 ?  337 HIS A O   1 
ATOM   2321 C CB  . HIS A 1 337 ? 126.894 100.549 127.892 1.00 193.41 ?  337 HIS A CB  1 
ATOM   2322 C CG  . HIS A 1 337 ? 126.357 101.804 128.506 1.00 196.04 ?  337 HIS A CG  1 
ATOM   2323 N ND1 . HIS A 1 337 ? 126.609 103.055 127.985 1.00 196.35 ?  337 HIS A ND1 1 
ATOM   2324 C CD2 . HIS A 1 337 ? 125.564 101.999 129.585 1.00 197.74 ?  337 HIS A CD2 1 
ATOM   2325 C CE1 . HIS A 1 337 ? 126.004 103.967 128.725 1.00 197.52 ?  337 HIS A CE1 1 
ATOM   2326 N NE2 . HIS A 1 337 ? 125.363 103.352 129.702 1.00 199.87 ?  337 HIS A NE2 1 
ATOM   2327 N N   . LEU A 1 338 ? 126.262 101.580 125.004 1.00 179.22 ?  338 LEU A N   1 
ATOM   2328 C CA  . LEU A 1 338 ? 125.801 102.608 124.081 1.00 178.78 ?  338 LEU A CA  1 
ATOM   2329 C C   . LEU A 1 338 ? 124.714 102.086 123.157 1.00 181.25 ?  338 LEU A C   1 
ATOM   2330 O O   . LEU A 1 338 ? 123.738 102.796 122.891 1.00 183.31 ?  338 LEU A O   1 
ATOM   2331 C CB  . LEU A 1 338 ? 126.971 103.142 123.261 1.00 176.79 ?  338 LEU A CB  1 
ATOM   2332 C CG  . LEU A 1 338 ? 127.725 104.294 123.915 1.00 181.87 ?  338 LEU A CG  1 
ATOM   2333 C CD1 . LEU A 1 338 ? 129.002 104.569 123.166 1.00 181.90 ?  338 LEU A CD1 1 
ATOM   2334 C CD2 . LEU A 1 338 ? 126.861 105.531 123.967 1.00 183.21 ?  338 LEU A CD2 1 
ATOM   2335 N N   . PHE A 1 339 ? 124.865 100.860 122.656 1.00 166.15 ?  339 PHE A N   1 
ATOM   2336 C CA  . PHE A 1 339 ? 123.854 100.289 121.777 1.00 166.76 ?  339 PHE A CA  1 
ATOM   2337 C C   . PHE A 1 339 ? 122.527 100.135 122.504 1.00 167.12 ?  339 PHE A C   1 
ATOM   2338 O O   . PHE A 1 339 ? 121.470 100.456 121.958 1.00 168.45 ?  339 PHE A O   1 
ATOM   2339 C CB  . PHE A 1 339 ? 124.320 98.941  121.230 1.00 166.97 ?  339 PHE A CB  1 
ATOM   2340 C CG  . PHE A 1 339 ? 123.407 98.375  120.183 1.00 167.21 ?  339 PHE A CG  1 
ATOM   2341 C CD1 . PHE A 1 339 ? 122.871 99.189  119.203 1.00 166.63 ?  339 PHE A CD1 1 
ATOM   2342 C CD2 . PHE A 1 339 ? 123.063 97.037  120.195 1.00 169.19 ?  339 PHE A CD2 1 
ATOM   2343 C CE1 . PHE A 1 339 ? 122.025 98.675  118.244 1.00 166.47 ?  339 PHE A CE1 1 
ATOM   2344 C CE2 . PHE A 1 339 ? 122.216 96.517  119.239 1.00 168.26 ?  339 PHE A CE2 1 
ATOM   2345 C CZ  . PHE A 1 339 ? 121.697 97.337  118.262 1.00 166.42 ?  339 PHE A CZ  1 
ATOM   2346 N N   . LEU A 1 340 ? 122.563 99.646  123.744 1.00 165.53 ?  340 LEU A N   1 
ATOM   2347 C CA  . LEU A 1 340 ? 121.326 99.495  124.503 1.00 162.23 ?  340 LEU A CA  1 
ATOM   2348 C C   . LEU A 1 340 ? 120.656 100.844 124.727 1.00 161.66 ?  340 LEU A C   1 
ATOM   2349 O O   . LEU A 1 340 ? 119.448 100.995 124.507 1.00 166.63 ?  340 LEU A O   1 
ATOM   2350 C CB  . LEU A 1 340 ? 121.602 98.802  125.838 1.00 162.63 ?  340 LEU A CB  1 
ATOM   2351 C CG  . LEU A 1 340 ? 122.009 97.330  125.768 1.00 166.26 ?  340 LEU A CG  1 
ATOM   2352 C CD1 . LEU A 1 340 ? 122.231 96.770  127.163 1.00 163.90 ?  340 LEU A CD1 1 
ATOM   2353 C CD2 . LEU A 1 340 ? 120.962 96.520  125.024 1.00 165.02 ?  340 LEU A CD2 1 
ATOM   2354 N N   . CYS A 1 341 ? 121.432 101.846 125.147 1.00 171.90 ?  341 CYS A N   1 
ATOM   2355 C CA  . CYS A 1 341 ? 120.847 103.155 125.422 1.00 175.37 ?  341 CYS A CA  1 
ATOM   2356 C C   . CYS A 1 341 ? 120.256 103.774 124.159 1.00 177.48 ?  341 CYS A C   1 
ATOM   2357 O O   . CYS A 1 341 ? 119.126 104.282 124.168 1.00 183.45 ?  341 CYS A O   1 
ATOM   2358 C CB  . CYS A 1 341 ? 121.897 104.075 126.038 1.00 178.41 ?  341 CYS A CB  1 
ATOM   2359 S SG  . CYS A 1 341 ? 122.380 103.623 127.718 1.00 189.25 ?  341 CYS A SG  1 
ATOM   2360 N N   . LEU A 1 342 ? 120.998 103.721 123.051 1.00 154.28 ?  342 LEU A N   1 
ATOM   2361 C CA  . LEU A 1 342 ? 120.518 104.332 121.819 1.00 155.58 ?  342 LEU A CA  1 
ATOM   2362 C C   . LEU A 1 342 ? 119.346 103.561 121.230 1.00 157.02 ?  342 LEU A C   1 
ATOM   2363 O O   . LEU A 1 342 ? 118.443 104.166 120.642 1.00 160.72 ?  342 LEU A O   1 
ATOM   2364 C CB  . LEU A 1 342 ? 121.660 104.435 120.811 1.00 151.24 ?  342 LEU A CB  1 
ATOM   2365 C CG  . LEU A 1 342 ? 122.674 105.525 121.160 1.00 152.98 ?  342 LEU A CG  1 
ATOM   2366 C CD1 . LEU A 1 342 ? 123.981 105.309 120.424 1.00 156.95 ?  342 LEU A CD1 1 
ATOM   2367 C CD2 . LEU A 1 342 ? 122.109 106.898 120.858 1.00 152.02 ?  342 LEU A CD2 1 
ATOM   2368 N N   . SER A 1 343 ? 119.335 102.235 121.378 1.00 155.64 ?  343 SER A N   1 
ATOM   2369 C CA  . SER A 1 343 ? 118.190 101.453 120.938 1.00 153.18 ?  343 SER A CA  1 
ATOM   2370 C C   . SER A 1 343 ? 116.948 101.819 121.731 1.00 152.82 ?  343 SER A C   1 
ATOM   2371 O O   . SER A 1 343 ? 115.865 101.970 121.159 1.00 160.20 ?  343 SER A O   1 
ATOM   2372 C CB  . SER A 1 343 ? 118.491 99.962  121.070 1.00 155.83 ?  343 SER A CB  1 
ATOM   2373 O OG  . SER A 1 343 ? 119.545 99.580  120.204 1.00 160.91 ?  343 SER A OG  1 
ATOM   2374 N N   . MET A 1 344 ? 117.083 101.974 123.051 1.00 148.52 ?  344 MET A N   1 
ATOM   2375 C CA  . MET A 1 344 ? 115.937 102.400 123.847 1.00 149.56 ?  344 MET A CA  1 
ATOM   2376 C C   . MET A 1 344 ? 115.446 103.773 123.410 1.00 151.60 ?  344 MET A C   1 
ATOM   2377 O O   . MET A 1 344 ? 114.236 103.989 123.277 1.00 157.75 ?  344 MET A O   1 
ATOM   2378 C CB  . MET A 1 344 ? 116.286 102.403 125.335 1.00 147.35 ?  344 MET A CB  1 
ATOM   2379 C CG  . MET A 1 344 ? 116.606 101.034 125.905 1.00 152.31 ?  344 MET A CG  1 
ATOM   2380 S SD  . MET A 1 344 ? 115.623 99.718  125.164 1.00 162.56 ?  344 MET A SD  1 
ATOM   2381 C CE  . MET A 1 344 ? 116.074 98.334  126.208 1.00 154.89 ?  344 MET A CE  1 
ATOM   2382 N N   . LEU A 1 345 ? 116.368 104.710 123.164 1.00 138.62 ?  345 LEU A N   1 
ATOM   2383 C CA  . LEU A 1 345 ? 115.948 106.045 122.743 1.00 136.87 ?  345 LEU A CA  1 
ATOM   2384 C C   . LEU A 1 345 ? 115.219 106.012 121.405 1.00 143.92 ?  345 LEU A C   1 
ATOM   2385 O O   . LEU A 1 345 ? 114.124 106.575 121.278 1.00 154.16 ?  345 LEU A O   1 
ATOM   2386 C CB  . LEU A 1 345 ? 117.147 106.987 122.673 1.00 136.22 ?  345 LEU A CB  1 
ATOM   2387 C CG  . LEU A 1 345 ? 117.784 107.330 124.017 1.00 143.57 ?  345 LEU A CG  1 
ATOM   2388 C CD1 . LEU A 1 345 ? 118.671 108.550 123.882 1.00 144.19 ?  345 LEU A CD1 1 
ATOM   2389 C CD2 . LEU A 1 345 ? 116.710 107.561 125.062 1.00 144.07 ?  345 LEU A CD2 1 
ATOM   2390 N N   . TRP A 1 346 ? 115.802 105.356 120.397 1.00 133.55 ?  346 TRP A N   1 
ATOM   2391 C CA  . TRP A 1 346 ? 115.154 105.269 119.091 1.00 132.79 ?  346 TRP A CA  1 
ATOM   2392 C C   . TRP A 1 346 ? 113.800 104.579 119.186 1.00 139.34 ?  346 TRP A C   1 
ATOM   2393 O O   . TRP A 1 346 ? 112.808 105.068 118.628 1.00 138.89 ?  346 TRP A O   1 
ATOM   2394 C CB  . TRP A 1 346 ? 116.043 104.511 118.105 1.00 137.87 ?  346 TRP A CB  1 
ATOM   2395 C CG  . TRP A 1 346 ? 117.125 105.324 117.462 1.00 144.65 ?  346 TRP A CG  1 
ATOM   2396 C CD1 . TRP A 1 346 ? 118.426 105.414 117.857 1.00 145.37 ?  346 TRP A CD1 1 
ATOM   2397 C CD2 . TRP A 1 346 ? 117.004 106.144 116.294 1.00 144.76 ?  346 TRP A CD2 1 
ATOM   2398 N NE1 . TRP A 1 346 ? 119.121 106.245 117.014 1.00 139.57 ?  346 TRP A NE1 1 
ATOM   2399 C CE2 . TRP A 1 346 ? 118.270 106.707 116.046 1.00 141.34 ?  346 TRP A CE2 1 
ATOM   2400 C CE3 . TRP A 1 346 ? 115.946 106.462 115.438 1.00 144.98 ?  346 TRP A CE3 1 
ATOM   2401 C CZ2 . TRP A 1 346 ? 118.507 107.568 114.979 1.00 142.76 ?  346 TRP A CZ2 1 
ATOM   2402 C CZ3 . TRP A 1 346 ? 116.184 107.317 114.379 1.00 140.24 ?  346 TRP A CZ3 1 
ATOM   2403 C CH2 . TRP A 1 346 ? 117.454 107.860 114.159 1.00 139.79 ?  346 TRP A CH2 1 
ATOM   2404 N N   . PHE A 1 347 ? 113.749 103.445 119.889 1.00 131.03 ?  347 PHE A N   1 
ATOM   2405 C CA  . PHE A 1 347 ? 112.513 102.686 120.017 1.00 123.64 ?  347 PHE A CA  1 
ATOM   2406 C C   . PHE A 1 347 ? 111.425 103.525 120.665 1.00 121.37 ?  347 PHE A C   1 
ATOM   2407 O O   . PHE A 1 347 ? 110.312 103.620 120.143 1.00 132.76 ?  347 PHE A O   1 
ATOM   2408 C CB  . PHE A 1 347 ? 112.777 101.418 120.829 1.00 120.56 ?  347 PHE A CB  1 
ATOM   2409 C CG  . PHE A 1 347 ? 111.569 100.556 121.029 1.00 116.23 ?  347 PHE A CG  1 
ATOM   2410 C CD1 . PHE A 1 347 ? 111.219 99.608  120.088 1.00 123.58 ?  347 PHE A CD1 1 
ATOM   2411 C CD2 . PHE A 1 347 ? 110.793 100.681 122.166 1.00 122.38 ?  347 PHE A CD2 1 
ATOM   2412 C CE1 . PHE A 1 347 ? 110.114 98.807  120.272 1.00 126.53 ?  347 PHE A CE1 1 
ATOM   2413 C CE2 . PHE A 1 347 ? 109.685 99.884  122.354 1.00 130.00 ?  347 PHE A CE2 1 
ATOM   2414 C CZ  . PHE A 1 347 ? 109.345 98.946  121.405 1.00 129.91 ?  347 PHE A CZ  1 
ATOM   2415 N N   . ALA A 1 348 ? 111.734 104.156 121.800 1.00 118.78 ?  348 ALA A N   1 
ATOM   2416 C CA  . ALA A 1 348 ? 110.730 104.941 122.505 1.00 127.00 ?  348 ALA A CA  1 
ATOM   2417 C C   . ALA A 1 348 ? 110.270 106.128 121.673 1.00 128.15 ?  348 ALA A C   1 
ATOM   2418 O O   . ALA A 1 348 ? 109.071 106.428 121.607 1.00 142.47 ?  348 ALA A O   1 
ATOM   2419 C CB  . ALA A 1 348 ? 111.286 105.412 123.845 1.00 126.65 ?  348 ALA A CB  1 
ATOM   2420 N N   . THR A 1 349 ? 111.211 106.821 121.027 1.00 107.83 ?  349 THR A N   1 
ATOM   2421 C CA  . THR A 1 349 ? 110.844 108.006 120.263 1.00 111.50 ?  349 THR A CA  1 
ATOM   2422 C C   . THR A 1 349 ? 109.929 107.642 119.101 1.00 118.14 ?  349 THR A C   1 
ATOM   2423 O O   . THR A 1 349 ? 108.864 108.245 118.926 1.00 130.88 ?  349 THR A O   1 
ATOM   2424 C CB  . THR A 1 349 ? 112.099 108.718 119.766 1.00 123.30 ?  349 THR A CB  1 
ATOM   2425 O OG1 . THR A 1 349 ? 112.929 109.047 120.885 1.00 131.09 ?  349 THR A OG1 1 
ATOM   2426 C CG2 . THR A 1 349 ? 111.719 109.998 119.066 1.00 123.51 ?  349 THR A CG2 1 
ATOM   2427 N N   . SER A 1 350 ? 110.314 106.636 118.310 1.00 120.46 ?  350 SER A N   1 
ATOM   2428 C CA  . SER A 1 350 ? 109.469 106.225 117.193 1.00 131.64 ?  350 SER A CA  1 
ATOM   2429 C C   . SER A 1 350 ? 108.137 105.667 117.678 1.00 129.20 ?  350 SER A C   1 
ATOM   2430 O O   . SER A 1 350 ? 107.095 105.903 117.057 1.00 123.46 ?  350 SER A O   1 
ATOM   2431 C CB  . SER A 1 350 ? 110.196 105.196 116.334 1.00 135.08 ?  350 SER A CB  1 
ATOM   2432 O OG  . SER A 1 350 ? 109.480 104.936 115.141 1.00 136.69 ?  350 SER A OG  1 
ATOM   2433 N N   . PHE A 1 351 ? 108.155 104.927 118.787 1.00 126.98 ?  351 PHE A N   1 
ATOM   2434 C CA  . PHE A 1 351 ? 106.943 104.327 119.327 1.00 120.70 ?  351 PHE A CA  1 
ATOM   2435 C C   . PHE A 1 351 ? 105.929 105.399 119.703 1.00 119.97 ?  351 PHE A C   1 
ATOM   2436 O O   . PHE A 1 351 ? 104.779 105.369 119.250 1.00 134.62 ?  351 PHE A O   1 
ATOM   2437 C CB  . PHE A 1 351 ? 107.334 103.463 120.528 1.00 120.11 ?  351 PHE A CB  1 
ATOM   2438 C CG  . PHE A 1 351 ? 106.191 102.799 121.223 1.00 113.58 ?  351 PHE A CG  1 
ATOM   2439 C CD1 . PHE A 1 351 ? 105.589 101.682 120.680 1.00 119.68 ?  351 PHE A CD1 1 
ATOM   2440 C CD2 . PHE A 1 351 ? 105.759 103.254 122.453 1.00 118.51 ?  351 PHE A CD2 1 
ATOM   2441 C CE1 . PHE A 1 351 ? 104.553 101.054 121.333 1.00 126.83 ?  351 PHE A CE1 1 
ATOM   2442 C CE2 . PHE A 1 351 ? 104.724 102.630 123.111 1.00 126.30 ?  351 PHE A CE2 1 
ATOM   2443 C CZ  . PHE A 1 351 ? 104.120 101.529 122.550 1.00 127.34 ?  351 PHE A CZ  1 
ATOM   2444 N N   . ALA A 1 352 ? 106.355 106.389 120.491 1.00 103.66 ?  352 ALA A N   1 
ATOM   2445 C CA  . ALA A 1 352 ? 105.452 107.473 120.865 1.00 107.21 ?  352 ALA A CA  1 
ATOM   2446 C C   . ALA A 1 352 ? 105.032 108.296 119.652 1.00 114.62 ?  352 ALA A C   1 
ATOM   2447 O O   . ALA A 1 352 ? 103.869 108.715 119.550 1.00 119.07 ?  352 ALA A O   1 
ATOM   2448 C CB  . ALA A 1 352 ? 106.112 108.364 121.913 1.00 109.88 ?  352 ALA A CB  1 
ATOM   2449 N N   . TYR A 1 353 ? 105.961 108.543 118.724 1.00 124.56 ?  353 TYR A N   1 
ATOM   2450 C CA  . TYR A 1 353 ? 105.635 109.349 117.554 1.00 126.13 ?  353 TYR A CA  1 
ATOM   2451 C C   . TYR A 1 353 ? 104.539 108.697 116.724 1.00 130.83 ?  353 TYR A C   1 
ATOM   2452 O O   . TYR A 1 353 ? 103.553 109.346 116.361 1.00 134.59 ?  353 TYR A O   1 
ATOM   2453 C CB  . TYR A 1 353 ? 106.888 109.576 116.711 1.00 121.08 ?  353 TYR A CB  1 
ATOM   2454 C CG  . TYR A 1 353 ? 106.644 110.410 115.481 1.00 116.43 ?  353 TYR A CG  1 
ATOM   2455 C CD1 . TYR A 1 353 ? 106.571 111.790 115.561 1.00 122.39 ?  353 TYR A CD1 1 
ATOM   2456 C CD2 . TYR A 1 353 ? 106.492 109.818 114.238 1.00 125.90 ?  353 TYR A CD2 1 
ATOM   2457 C CE1 . TYR A 1 353 ? 106.349 112.557 114.438 1.00 129.60 ?  353 TYR A CE1 1 
ATOM   2458 C CE2 . TYR A 1 353 ? 106.270 110.576 113.109 1.00 132.42 ?  353 TYR A CE2 1 
ATOM   2459 C CZ  . TYR A 1 353 ? 106.200 111.945 113.215 1.00 131.11 ?  353 TYR A CZ  1 
ATOM   2460 O OH  . TYR A 1 353 ? 105.979 112.708 112.093 1.00 129.08 ?  353 TYR A OH  1 
ATOM   2461 N N   . TYR A 1 354 ? 104.685 107.406 116.426 1.00 129.27 ?  354 TYR A N   1 
ATOM   2462 C CA  . TYR A 1 354 ? 103.682 106.737 115.608 1.00 123.46 ?  354 TYR A CA  1 
ATOM   2463 C C   . TYR A 1 354 ? 102.422 106.444 116.409 1.00 121.35 ?  354 TYR A C   1 
ATOM   2464 O O   . TYR A 1 354 ? 101.354 106.216 115.832 1.00 128.66 ?  354 TYR A O   1 
ATOM   2465 C CB  . TYR A 1 354 ? 104.260 105.463 115.002 1.00 118.16 ?  354 TYR A CB  1 
ATOM   2466 C CG  . TYR A 1 354 ? 105.029 105.731 113.733 1.00 120.55 ?  354 TYR A CG  1 
ATOM   2467 C CD1 . TYR A 1 354 ? 104.371 106.020 112.549 1.00 123.22 ?  354 TYR A CD1 1 
ATOM   2468 C CD2 . TYR A 1 354 ? 106.415 105.722 113.726 1.00 121.93 ?  354 TYR A CD2 1 
ATOM   2469 C CE1 . TYR A 1 354 ? 105.072 106.275 111.387 1.00 123.84 ?  354 TYR A CE1 1 
ATOM   2470 C CE2 . TYR A 1 354 ? 107.125 105.976 112.570 1.00 125.73 ?  354 TYR A CE2 1 
ATOM   2471 C CZ  . TYR A 1 354 ? 106.448 106.252 111.403 1.00 124.69 ?  354 TYR A CZ  1 
ATOM   2472 O OH  . TYR A 1 354 ? 107.149 106.507 110.247 1.00 124.17 ?  354 TYR A OH  1 
ATOM   2473 N N   . GLY A 1 355 ? 102.519 106.450 117.738 1.00 123.73 ?  355 GLY A N   1 
ATOM   2474 C CA  . GLY A 1 355 ? 101.308 106.406 118.536 1.00 120.46 ?  355 GLY A CA  1 
ATOM   2475 C C   . GLY A 1 355 ? 100.475 107.662 118.387 1.00 126.39 ?  355 GLY A C   1 
ATOM   2476 O O   . GLY A 1 355 ? 99.248  107.601 118.283 1.00 129.76 ?  355 GLY A O   1 
ATOM   2477 N N   . LEU A 1 356 ? 101.134 108.826 118.392 1.00 134.26 ?  356 LEU A N   1 
ATOM   2478 C CA  . LEU A 1 356 ? 100.399 110.091 118.331 1.00 137.40 ?  356 LEU A CA  1 
ATOM   2479 C C   . LEU A 1 356 ? 99.970  110.460 116.923 1.00 139.35 ?  356 LEU A C   1 
ATOM   2480 O O   . LEU A 1 356 ? 98.883  111.019 116.734 1.00 144.02 ?  356 LEU A O   1 
ATOM   2481 C CB  . LEU A 1 356 ? 101.210 111.217 118.961 1.00 136.36 ?  356 LEU A CB  1 
ATOM   2482 C CG  . LEU A 1 356 ? 100.259 111.965 119.884 1.00 146.44 ?  356 LEU A CG  1 
ATOM   2483 C CD1 . LEU A 1 356 ? 99.688  111.014 120.889 1.00 146.67 ?  356 LEU A CD1 1 
ATOM   2484 C CD2 . LEU A 1 356 ? 101.007 113.091 120.577 1.00 144.32 ?  356 LEU A CD2 1 
ATOM   2485 N N   . VAL A 1 357 ? 100.796 110.164 115.923 1.00 135.23 ?  357 VAL A N   1 
ATOM   2486 C CA  . VAL A 1 357 ? 100.466 110.624 114.582 1.00 133.52 ?  357 VAL A CA  1 
ATOM   2487 C C   . VAL A 1 357 ? 99.166  109.997 114.092 1.00 145.04 ?  357 VAL A C   1 
ATOM   2488 O O   . VAL A 1 357 ? 98.390  110.649 113.386 1.00 153.42 ?  357 VAL A O   1 
ATOM   2489 C CB  . VAL A 1 357 ? 101.636 110.345 113.626 1.00 132.74 ?  357 VAL A CB  1 
ATOM   2490 C CG1 . VAL A 1 357 ? 101.232 110.610 112.201 1.00 133.62 ?  357 VAL A CG1 1 
ATOM   2491 C CG2 . VAL A 1 357 ? 102.809 111.198 114.005 1.00 136.74 ?  357 VAL A CG2 1 
ATOM   2492 N N   . MET A 1 358 ? 98.887  108.747 114.461 1.00 150.04 ?  358 MET A N   1 
ATOM   2493 C CA  . MET A 1 358 ? 97.760  108.021 113.889 1.00 147.80 ?  358 MET A CA  1 
ATOM   2494 C C   . MET A 1 358 ? 96.540  107.938 114.810 1.00 146.97 ?  358 MET A C   1 
ATOM   2495 O O   . MET A 1 358 ? 95.705  107.048 114.627 1.00 152.71 ?  358 MET A O   1 
ATOM   2496 C CB  . MET A 1 358 ? 98.211  106.626 113.475 1.00 144.76 ?  358 MET A CB  1 
ATOM   2497 C CG  . MET A 1 358 ? 99.465  106.674 112.626 1.00 145.81 ?  358 MET A CG  1 
ATOM   2498 S SD  . MET A 1 358 ? 99.063  106.734 110.879 1.00 163.30 ?  358 MET A SD  1 
ATOM   2499 C CE  . MET A 1 358 ? 99.650  105.143 110.341 1.00 151.63 ?  358 MET A CE  1 
ATOM   2500 N N   . ASP A 1 359 ? 96.425  108.828 115.802 1.00 149.00 ?  359 ASP A N   1 
ATOM   2501 C CA  . ASP A 1 359 ? 95.187  109.021 116.567 1.00 153.06 ?  359 ASP A CA  1 
ATOM   2502 C C   . ASP A 1 359 ? 94.711  110.453 116.317 1.00 152.48 ?  359 ASP A C   1 
ATOM   2503 O O   . ASP A 1 359 ? 95.102  111.382 117.023 1.00 158.14 ?  359 ASP A O   1 
ATOM   2504 C CB  . ASP A 1 359 ? 95.386  108.754 118.066 1.00 157.79 ?  359 ASP A CB  1 
ATOM   2505 C CG  . ASP A 1 359 ? 95.823  107.336 118.358 1.00 157.59 ?  359 ASP A CG  1 
ATOM   2506 O OD1 . ASP A 1 359 ? 96.063  107.021 119.544 1.00 159.76 ?  359 ASP A OD1 1 
ATOM   2507 O OD2 . ASP A 1 359 ? 95.895  106.528 117.409 1.00 153.96 -1 359 ASP A OD2 1 
ATOM   2508 N N   . LEU A 1 360 ? 93.864  110.627 115.301 1.00 141.93 ?  360 LEU A N   1 
ATOM   2509 C CA  . LEU A 1 360 ? 93.465  111.960 114.870 1.00 143.69 ?  360 LEU A CA  1 
ATOM   2510 C C   . LEU A 1 360 ? 91.996  112.267 115.121 1.00 142.60 ?  360 LEU A C   1 
ATOM   2511 O O   . LEU A 1 360 ? 91.636  113.444 115.245 1.00 143.86 ?  360 LEU A O   1 
ATOM   2512 C CB  . LEU A 1 360 ? 93.766  112.137 113.381 1.00 137.93 ?  360 LEU A CB  1 
ATOM   2513 C CG  . LEU A 1 360 ? 95.228  111.942 112.992 1.00 131.97 ?  360 LEU A CG  1 
ATOM   2514 C CD1 . LEU A 1 360 ? 95.414  112.174 111.509 1.00 141.61 ?  360 LEU A CD1 1 
ATOM   2515 C CD2 . LEU A 1 360 ? 96.097  112.884 113.794 1.00 134.04 ?  360 LEU A CD2 1 
ATOM   2516 N N   . GLN A 1 361 ? 91.142  111.250 115.201 1.00 141.91 ?  361 GLN A N   1 
ATOM   2517 C CA  . GLN A 1 361 ? 89.712  111.502 115.316 1.00 142.23 ?  361 GLN A CA  1 
ATOM   2518 C C   . GLN A 1 361 ? 89.301  111.929 116.718 1.00 146.86 ?  361 GLN A C   1 
ATOM   2519 O O   . GLN A 1 361 ? 88.321  112.666 116.871 1.00 151.36 ?  361 GLN A O   1 
ATOM   2520 C CB  . GLN A 1 361 ? 88.926  110.260 114.898 1.00 149.35 ?  361 GLN A CB  1 
ATOM   2521 C CG  . GLN A 1 361 ? 89.279  109.743 113.517 1.00 149.64 ?  361 GLN A CG  1 
ATOM   2522 C CD  . GLN A 1 361 ? 88.277  108.733 113.001 1.00 146.53 ?  361 GLN A CD  1 
ATOM   2523 O OE1 . GLN A 1 361 ? 88.466  107.528 113.149 1.00 146.53 ?  361 GLN A OE1 1 
ATOM   2524 N NE2 . GLN A 1 361 ? 87.202  109.219 112.391 1.00 143.56 ?  361 GLN A NE2 1 
ATOM   2525 N N   . GLY A 1 362 ? 90.029  111.487 117.745 1.00 157.46 ?  362 GLY A N   1 
ATOM   2526 C CA  . GLY A 1 362 ? 89.560  111.670 119.108 1.00 162.16 ?  362 GLY A CA  1 
ATOM   2527 C C   . GLY A 1 362 ? 89.699  113.087 119.630 1.00 161.30 ?  362 GLY A C   1 
ATOM   2528 O O   . GLY A 1 362 ? 89.117  113.428 120.663 1.00 159.25 ?  362 GLY A O   1 
ATOM   2529 N N   . PHE A 1 363 ? 90.467  113.930 118.936 1.00 141.25 ?  363 PHE A N   1 
ATOM   2530 C CA  . PHE A 1 363 ? 90.702  115.280 119.441 1.00 141.14 ?  363 PHE A CA  1 
ATOM   2531 C C   . PHE A 1 363 ? 89.462  116.159 119.335 1.00 139.68 ?  363 PHE A C   1 
ATOM   2532 O O   . PHE A 1 363 ? 89.412  117.231 119.947 1.00 137.84 ?  363 PHE A O   1 
ATOM   2533 C CB  . PHE A 1 363 ? 91.880  115.925 118.711 1.00 136.08 ?  363 PHE A CB  1 
ATOM   2534 C CG  . PHE A 1 363 ? 93.156  115.143 118.813 1.00 129.43 ?  363 PHE A CG  1 
ATOM   2535 C CD1 . PHE A 1 363 ? 93.429  114.387 119.938 1.00 131.88 ?  363 PHE A CD1 1 
ATOM   2536 C CD2 . PHE A 1 363 ? 94.091  115.179 117.796 1.00 135.67 ?  363 PHE A CD2 1 
ATOM   2537 C CE1 . PHE A 1 363 ? 94.602  113.670 120.041 1.00 139.53 ?  363 PHE A CE1 1 
ATOM   2538 C CE2 . PHE A 1 363 ? 95.268  114.466 117.895 1.00 140.22 ?  363 PHE A CE2 1 
ATOM   2539 C CZ  . PHE A 1 363 ? 95.523  113.711 119.020 1.00 139.90 ?  363 PHE A CZ  1 
ATOM   2540 N N   . GLY A 1 364 ? 88.459  115.733 118.576 1.00 144.18 ?  364 GLY A N   1 
ATOM   2541 C CA  . GLY A 1 364 ? 87.224  116.479 118.461 1.00 147.47 ?  364 GLY A CA  1 
ATOM   2542 C C   . GLY A 1 364 ? 87.187  117.523 117.369 1.00 148.17 ?  364 GLY A C   1 
ATOM   2543 O O   . GLY A 1 364 ? 86.143  118.158 117.183 1.00 143.47 ?  364 GLY A O   1 
ATOM   2544 N N   . VAL A 1 365 ? 88.283  117.724 116.647 1.00 141.19 ?  365 VAL A N   1 
ATOM   2545 C CA  . VAL A 1 365 ? 88.325  118.662 115.537 1.00 140.83 ?  365 VAL A CA  1 
ATOM   2546 C C   . VAL A 1 365 ? 88.441  117.873 114.240 1.00 140.90 ?  365 VAL A C   1 
ATOM   2547 O O   . VAL A 1 365 ? 88.755  116.679 114.232 1.00 141.99 ?  365 VAL A O   1 
ATOM   2548 C CB  . VAL A 1 365 ? 89.484  119.668 115.675 1.00 141.36 ?  365 VAL A CB  1 
ATOM   2549 C CG1 . VAL A 1 365 ? 89.409  120.377 117.014 1.00 138.95 ?  365 VAL A CG1 1 
ATOM   2550 C CG2 . VAL A 1 365 ? 90.816  118.959 115.521 1.00 139.97 ?  365 VAL A CG2 1 
ATOM   2551 N N   . SER A 1 366 ? 88.170  118.556 113.129 1.00 134.42 ?  366 SER A N   1 
ATOM   2552 C CA  . SER A 1 366 ? 88.249  117.915 111.824 1.00 134.84 ?  366 SER A CA  1 
ATOM   2553 C C   . SER A 1 366 ? 89.663  117.410 111.571 1.00 138.01 ?  366 SER A C   1 
ATOM   2554 O O   . SER A 1 366 ? 90.646  118.127 111.775 1.00 140.40 ?  366 SER A O   1 
ATOM   2555 C CB  . SER A 1 366 ? 87.832  118.894 110.725 1.00 136.82 ?  366 SER A CB  1 
ATOM   2556 O OG  . SER A 1 366 ? 88.019  118.326 109.442 1.00 140.00 ?  366 SER A OG  1 
ATOM   2557 N N   . ILE A 1 367 ? 89.763  116.156 111.121 1.00 131.42 ?  367 ILE A N   1 
ATOM   2558 C CA  . ILE A 1 367 ? 91.070  115.511 111.005 1.00 134.30 ?  367 ILE A CA  1 
ATOM   2559 C C   . ILE A 1 367 ? 91.957  116.142 109.946 1.00 132.82 ?  367 ILE A C   1 
ATOM   2560 O O   . ILE A 1 367 ? 93.184  116.044 110.048 1.00 128.42 ?  367 ILE A O   1 
ATOM   2561 C CB  . ILE A 1 367 ? 90.934  114.004 110.726 1.00 126.68 ?  367 ILE A CB  1 
ATOM   2562 C CG1 . ILE A 1 367 ? 90.310  113.756 109.358 1.00 123.74 ?  367 ILE A CG1 1 
ATOM   2563 C CG2 . ILE A 1 367 ? 90.106  113.339 111.806 1.00 128.74 ?  367 ILE A CG2 1 
ATOM   2564 C CD1 . ILE A 1 367 ? 90.589  112.379 108.838 1.00 124.18 ?  367 ILE A CD1 1 
ATOM   2565 N N   . TYR A 1 368 ? 91.385  116.785 108.932 1.00 139.15 ?  368 TYR A N   1 
ATOM   2566 C CA  . TYR A 1 368 ? 92.210  117.549 108.006 1.00 140.00 ?  368 TYR A CA  1 
ATOM   2567 C C   . TYR A 1 368 ? 92.867  118.740 108.692 1.00 143.48 ?  368 TYR A C   1 
ATOM   2568 O O   . TYR A 1 368 ? 94.055  119.007 108.474 1.00 147.90 ?  368 TYR A O   1 
ATOM   2569 C CB  . TYR A 1 368 ? 91.369  118.019 106.818 1.00 137.21 ?  368 TYR A CB  1 
ATOM   2570 C CG  . TYR A 1 368 ? 90.580  116.909 106.168 1.00 134.92 ?  368 TYR A CG  1 
ATOM   2571 C CD1 . TYR A 1 368 ? 91.184  116.031 105.283 1.00 135.12 ?  368 TYR A CD1 1 
ATOM   2572 C CD2 . TYR A 1 368 ? 89.233  116.735 106.447 1.00 136.55 ?  368 TYR A CD2 1 
ATOM   2573 C CE1 . TYR A 1 368 ? 90.468  115.013 104.688 1.00 139.09 ?  368 TYR A CE1 1 
ATOM   2574 C CE2 . TYR A 1 368 ? 88.508  115.721 105.858 1.00 141.60 ?  368 TYR A CE2 1 
ATOM   2575 C CZ  . TYR A 1 368 ? 89.130  114.863 104.979 1.00 144.52 ?  368 TYR A CZ  1 
ATOM   2576 O OH  . TYR A 1 368 ? 88.410  113.850 104.390 1.00 144.24 ?  368 TYR A OH  1 
ATOM   2577 N N   . LEU A 1 369 ? 92.115  119.451 109.533 1.00 131.20 ?  369 LEU A N   1 
ATOM   2578 C CA  . LEU A 1 369 ? 92.695  120.556 110.287 1.00 127.53 ?  369 LEU A CA  1 
ATOM   2579 C C   . LEU A 1 369 ? 93.773  120.064 111.243 1.00 128.86 ?  369 LEU A C   1 
ATOM   2580 O O   . LEU A 1 369 ? 94.824  120.701 111.383 1.00 132.03 ?  369 LEU A O   1 
ATOM   2581 C CB  . LEU A 1 369 ? 91.603  121.304 111.050 1.00 131.80 ?  369 LEU A CB  1 
ATOM   2582 C CG  . LEU A 1 369 ? 92.088  122.412 111.986 1.00 127.80 ?  369 LEU A CG  1 
ATOM   2583 C CD1 . LEU A 1 369 ? 92.837  123.478 111.203 1.00 124.57 ?  369 LEU A CD1 1 
ATOM   2584 C CD2 . LEU A 1 369 ? 90.927  123.020 112.758 1.00 131.49 ?  369 LEU A CD2 1 
ATOM   2585 N N   . ILE A 1 370 ? 93.535  118.934 111.915 1.00 120.95 ?  370 ILE A N   1 
ATOM   2586 C CA  . ILE A 1 370 ? 94.533  118.420 112.847 1.00 120.05 ?  370 ILE A CA  1 
ATOM   2587 C C   . ILE A 1 370 ? 95.767  117.943 112.092 1.00 129.08 ?  370 ILE A C   1 
ATOM   2588 O O   . ILE A 1 370 ? 96.893  118.056 112.586 1.00 132.61 ?  370 ILE A O   1 
ATOM   2589 C CB  . ILE A 1 370 ? 93.939  117.316 113.743 1.00 111.47 ?  370 ILE A CB  1 
ATOM   2590 C CG1 . ILE A 1 370 ? 94.753  117.193 115.023 1.00 119.33 ?  370 ILE A CG1 1 
ATOM   2591 C CG2 . ILE A 1 370 ? 93.960  115.974 113.063 1.00 121.14 ?  370 ILE A CG2 1 
ATOM   2592 C CD1 . ILE A 1 370 ? 94.582  118.358 115.942 1.00 128.41 ?  370 ILE A CD1 1 
ATOM   2593 N N   . GLN A 1 371 ? 95.582  117.420 110.876 1.00 129.30 ?  371 GLN A N   1 
ATOM   2594 C CA  . GLN A 1 371 ? 96.728  117.030 110.062 1.00 125.60 ?  371 GLN A CA  1 
ATOM   2595 C C   . GLN A 1 371 ? 97.544  118.246 109.645 1.00 128.45 ?  371 GLN A C   1 
ATOM   2596 O O   . GLN A 1 371 ? 98.780  118.219 109.690 1.00 130.96 ?  371 GLN A O   1 
ATOM   2597 C CB  . GLN A 1 371 ? 96.259  116.252 108.836 1.00 120.46 ?  371 GLN A CB  1 
ATOM   2598 C CG  . GLN A 1 371 ? 97.383  115.790 107.932 1.00 123.12 ?  371 GLN A CG  1 
ATOM   2599 C CD  . GLN A 1 371 ? 98.192  114.664 108.534 1.00 131.87 ?  371 GLN A CD  1 
ATOM   2600 O OE1 . GLN A 1 371 ? 97.778  114.036 109.507 1.00 129.48 ?  371 GLN A OE1 1 
ATOM   2601 N NE2 . GLN A 1 371 ? 99.355  114.398 107.954 1.00 136.49 ?  371 GLN A NE2 1 
ATOM   2602 N N   . VAL A 1 372 ? 96.868  119.324 109.243 1.00 116.40 ?  372 VAL A N   1 
ATOM   2603 C CA  . VAL A 1 372 ? 97.571  120.560 108.907 1.00 109.66 ?  372 VAL A CA  1 
ATOM   2604 C C   . VAL A 1 372 ? 98.339  121.078 110.115 1.00 118.78 ?  372 VAL A C   1 
ATOM   2605 O O   . VAL A 1 372 ? 99.506  121.476 110.007 1.00 125.93 ?  372 VAL A O   1 
ATOM   2606 C CB  . VAL A 1 372 ? 96.583  121.614 108.376 1.00 106.30 ?  372 VAL A CB  1 
ATOM   2607 C CG1 . VAL A 1 372 ? 97.160  123.008 108.528 1.00 109.41 ?  372 VAL A CG1 1 
ATOM   2608 C CG2 . VAL A 1 372 ? 96.254  121.344 106.925 1.00 117.78 ?  372 VAL A CG2 1 
ATOM   2609 N N   . ILE A 1 373 ? 97.701  121.072 111.286 1.00 124.30 ?  373 ILE A N   1 
ATOM   2610 C CA  . ILE A 1 373 ? 98.360  121.566 112.491 1.00 116.32 ?  373 ILE A CA  1 
ATOM   2611 C C   . ILE A 1 373 ? 99.578  120.711 112.816 1.00 118.89 ?  373 ILE A C   1 
ATOM   2612 O O   . ILE A 1 373 ? 100.653 121.233 113.129 1.00 131.97 ?  373 ILE A O   1 
ATOM   2613 C CB  . ILE A 1 373 ? 97.372  121.614 113.669 1.00 116.26 ?  373 ILE A CB  1 
ATOM   2614 C CG1 . ILE A 1 373 ? 96.319  122.696 113.442 1.00 128.31 ?  373 ILE A CG1 1 
ATOM   2615 C CG2 . ILE A 1 373 ? 98.102  121.917 114.947 1.00 116.08 ?  373 ILE A CG2 1 
ATOM   2616 C CD1 . ILE A 1 373 ? 95.078  122.519 114.288 1.00 123.88 ?  373 ILE A CD1 1 
ATOM   2617 N N   . PHE A 1 374 ? 99.430  119.384 112.737 1.00 115.52 ?  374 PHE A N   1 
ATOM   2618 C CA  . PHE A 1 374 ? 100.544 118.486 113.023 1.00 118.90 ?  374 PHE A CA  1 
ATOM   2619 C C   . PHE A 1 374 ? 101.699 118.714 112.062 1.00 125.88 ?  374 PHE A C   1 
ATOM   2620 O O   . PHE A 1 374 ? 102.867 118.692 112.465 1.00 131.97 ?  374 PHE A O   1 
ATOM   2621 C CB  . PHE A 1 374 ? 100.081 117.030 112.959 1.00 119.02 ?  374 PHE A CB  1 
ATOM   2622 C CG  . PHE A 1 374 ? 99.572  116.497 114.265 1.00 130.42 ?  374 PHE A CG  1 
ATOM   2623 C CD1 . PHE A 1 374 ? 100.203 116.818 115.451 1.00 130.66 ?  374 PHE A CD1 1 
ATOM   2624 C CD2 . PHE A 1 374 ? 98.467  115.668 114.308 1.00 132.79 ?  374 PHE A CD2 1 
ATOM   2625 C CE1 . PHE A 1 374 ? 99.738  116.328 116.654 1.00 130.61 ?  374 PHE A CE1 1 
ATOM   2626 C CE2 . PHE A 1 374 ? 98.000  115.177 115.509 1.00 125.72 ?  374 PHE A CE2 1 
ATOM   2627 C CZ  . PHE A 1 374 ? 98.637  115.506 116.682 1.00 119.36 ?  374 PHE A CZ  1 
ATOM   2628 N N   . GLY A 1 375 ? 101.395 118.922 110.780 1.00 128.72 ?  375 GLY A N   1 
ATOM   2629 C CA  . GLY A 1 375 ? 102.439 119.270 109.835 1.00 127.04 ?  375 GLY A CA  1 
ATOM   2630 C C   . GLY A 1 375 ? 103.108 120.589 110.158 1.00 125.97 ?  375 GLY A C   1 
ATOM   2631 O O   . GLY A 1 375 ? 104.313 120.747 109.941 1.00 126.76 ?  375 GLY A O   1 
ATOM   2632 N N   . ALA A 1 376 ? 102.347 121.547 110.677 1.00 130.67 ?  376 ALA A N   1 
ATOM   2633 C CA  . ALA A 1 376 ? 102.884 122.857 111.017 1.00 130.78 ?  376 ALA A CA  1 
ATOM   2634 C C   . ALA A 1 376 ? 103.673 122.869 112.320 1.00 133.47 ?  376 ALA A C   1 
ATOM   2635 O O   . ALA A 1 376 ? 104.425 123.818 112.555 1.00 137.60 ?  376 ALA A O   1 
ATOM   2636 C CB  . ALA A 1 376 ? 101.753 123.886 111.096 1.00 131.16 ?  376 ALA A CB  1 
ATOM   2637 N N   . VAL A 1 377 ? 103.510 121.864 113.178 1.00 133.43 ?  377 VAL A N   1 
ATOM   2638 C CA  . VAL A 1 377 ? 104.295 121.833 114.414 1.00 127.02 ?  377 VAL A CA  1 
ATOM   2639 C C   . VAL A 1 377 ? 105.784 121.649 114.138 1.00 138.51 ?  377 VAL A C   1 
ATOM   2640 O O   . VAL A 1 377 ? 106.615 122.220 114.849 1.00 150.47 ?  377 VAL A O   1 
ATOM   2641 C CB  . VAL A 1 377 ? 103.821 120.742 115.388 1.00 122.85 ?  377 VAL A CB  1 
ATOM   2642 C CG1 . VAL A 1 377 ? 104.328 121.046 116.782 1.00 125.45 ?  377 VAL A CG1 1 
ATOM   2643 C CG2 . VAL A 1 377 ? 102.338 120.645 115.413 1.00 136.20 ?  377 VAL A CG2 1 
ATOM   2644 N N   . ASP A 1 378 ? 106.141 120.852 113.130 1.00 146.47 ?  378 ASP A N   1 
ATOM   2645 C CA  . ASP A 1 378 ? 107.533 120.461 112.944 1.00 145.72 ?  378 ASP A CA  1 
ATOM   2646 C C   . ASP A 1 378 ? 108.446 121.637 112.625 1.00 142.95 ?  378 ASP A C   1 
ATOM   2647 O O   . ASP A 1 378 ? 109.593 121.651 113.082 1.00 139.93 ?  378 ASP A O   1 
ATOM   2648 C CB  . ASP A 1 378 ? 107.635 119.409 111.839 1.00 150.99 ?  378 ASP A CB  1 
ATOM   2649 C CG  . ASP A 1 378 ? 106.990 118.094 112.228 1.00 155.77 ?  378 ASP A CG  1 
ATOM   2650 O OD1 . ASP A 1 378 ? 106.336 118.045 113.291 1.00 149.07 ?  378 ASP A OD1 1 
ATOM   2651 O OD2 . ASP A 1 378 ? 107.138 117.109 111.475 1.00 159.07 -1 378 ASP A OD2 1 
ATOM   2652 N N   . LEU A 1 379 ? 107.974 122.619 111.857 1.00 149.49 ?  379 LEU A N   1 
ATOM   2653 C CA  . LEU A 1 379 ? 108.834 123.715 111.422 1.00 153.71 ?  379 LEU A CA  1 
ATOM   2654 C C   . LEU A 1 379 ? 109.380 124.514 112.606 1.00 154.63 ?  379 LEU A C   1 
ATOM   2655 O O   . LEU A 1 379 ? 110.591 124.764 112.656 1.00 158.51 ?  379 LEU A O   1 
ATOM   2656 C CB  . LEU A 1 379 ? 108.100 124.634 110.438 1.00 155.79 ?  379 LEU A CB  1 
ATOM   2657 C CG  . LEU A 1 379 ? 108.005 124.240 108.958 1.00 159.00 ?  379 LEU A CG  1 
ATOM   2658 C CD1 . LEU A 1 379 ? 107.433 122.842 108.757 1.00 153.35 ?  379 LEU A CD1 1 
ATOM   2659 C CD2 . LEU A 1 379 ? 107.188 125.268 108.189 1.00 156.58 ?  379 LEU A CD2 1 
ATOM   2660 N N   . PRO A 1 380 ? 108.558 124.936 113.577 1.00 140.26 ?  380 PRO A N   1 
ATOM   2661 C CA  . PRO A 1 380 ? 109.146 125.581 114.761 1.00 145.68 ?  380 PRO A CA  1 
ATOM   2662 C C   . PRO A 1 380 ? 109.756 124.596 115.741 1.00 147.33 ?  380 PRO A C   1 
ATOM   2663 O O   . PRO A 1 380 ? 110.682 124.968 116.472 1.00 152.28 ?  380 PRO A O   1 
ATOM   2664 C CB  . PRO A 1 380 ? 107.961 126.331 115.382 1.00 140.24 ?  380 PRO A CB  1 
ATOM   2665 C CG  . PRO A 1 380 ? 106.779 125.584 114.941 1.00 140.98 ?  380 PRO A CG  1 
ATOM   2666 C CD  . PRO A 1 380 ? 107.091 125.074 113.569 1.00 139.48 ?  380 PRO A CD  1 
ATOM   2667 N N   . ALA A 1 381 ? 109.262 123.358 115.789 1.00 142.08 ?  381 ALA A N   1 
ATOM   2668 C CA  . ALA A 1 381 ? 109.810 122.374 116.718 1.00 141.27 ?  381 ALA A CA  1 
ATOM   2669 C C   . ALA A 1 381 ? 111.265 122.066 116.390 1.00 146.53 ?  381 ALA A C   1 
ATOM   2670 O O   . ALA A 1 381 ? 112.111 121.963 117.286 1.00 150.87 ?  381 ALA A O   1 
ATOM   2671 C CB  . ALA A 1 381 ? 108.968 121.100 116.693 1.00 142.19 ?  381 ALA A CB  1 
ATOM   2672 N N   . LYS A 1 382 ? 111.575 121.913 115.101 1.00 161.69 ?  382 LYS A N   1 
ATOM   2673 C CA  . LYS A 1 382 ? 112.956 121.668 114.703 1.00 165.25 ?  382 LYS A CA  1 
ATOM   2674 C C   . LYS A 1 382 ? 113.853 122.854 115.029 1.00 163.75 ?  382 LYS A C   1 
ATOM   2675 O O   . LYS A 1 382 ? 114.994 122.663 115.459 1.00 161.27 ?  382 LYS A O   1 
ATOM   2676 C CB  . LYS A 1 382 ? 113.028 121.333 113.213 1.00 163.56 ?  382 LYS A CB  1 
ATOM   2677 C CG  . LYS A 1 382 ? 112.335 120.034 112.843 1.00 163.29 ?  382 LYS A CG  1 
ATOM   2678 C CD  . LYS A 1 382 ? 112.507 119.711 111.371 1.00 163.48 ?  382 LYS A CD  1 
ATOM   2679 C CE  . LYS A 1 382 ? 111.732 118.461 110.991 1.00 163.59 ?  382 LYS A CE  1 
ATOM   2680 N NZ  . LYS A 1 382 ? 112.129 117.288 111.816 1.00 161.77 1  382 LYS A NZ  1 
ATOM   2681 N N   . LEU A 1 383 ? 113.362 124.080 114.838 1.00 158.57 ?  383 LEU A N   1 
ATOM   2682 C CA  . LEU A 1 383 ? 114.149 125.259 115.192 1.00 159.06 ?  383 LEU A CA  1 
ATOM   2683 C C   . LEU A 1 383 ? 114.422 125.307 116.691 1.00 158.26 ?  383 LEU A C   1 
ATOM   2684 O O   . LEU A 1 383 ? 115.541 125.609 117.123 1.00 161.24 ?  383 LEU A O   1 
ATOM   2685 C CB  . LEU A 1 383 ? 113.430 126.533 114.738 1.00 155.63 ?  383 LEU A CB  1 
ATOM   2686 C CG  . LEU A 1 383 ? 113.689 127.073 113.329 1.00 155.82 ?  383 LEU A CG  1 
ATOM   2687 C CD1 . LEU A 1 383 ? 113.707 125.968 112.289 1.00 153.73 ?  383 LEU A CD1 1 
ATOM   2688 C CD2 . LEU A 1 383 ? 112.660 128.134 112.970 1.00 157.15 ?  383 LEU A CD2 1 
ATOM   2689 N N   . VAL A 1 384 ? 113.402 125.019 117.501 1.00 147.67 ?  384 VAL A N   1 
ATOM   2690 C CA  . VAL A 1 384 ? 113.581 125.031 118.951 1.00 149.74 ?  384 VAL A CA  1 
ATOM   2691 C C   . VAL A 1 384 ? 114.580 123.963 119.370 1.00 153.34 ?  384 VAL A C   1 
ATOM   2692 O O   . VAL A 1 384 ? 115.465 124.207 120.200 1.00 158.98 ?  384 VAL A O   1 
ATOM   2693 C CB  . VAL A 1 384 ? 112.227 124.854 119.663 1.00 149.80 ?  384 VAL A CB  1 
ATOM   2694 C CG1 . VAL A 1 384 ? 112.433 124.669 121.157 1.00 150.79 ?  384 VAL A CG1 1 
ATOM   2695 C CG2 . VAL A 1 384 ? 111.336 126.055 119.400 1.00 153.61 ?  384 VAL A CG2 1 
ATOM   2696 N N   . GLY A 1 385 ? 114.459 122.763 118.800 1.00 159.76 ?  385 GLY A N   1 
ATOM   2697 C CA  . GLY A 1 385 ? 115.415 121.712 119.107 1.00 164.81 ?  385 GLY A CA  1 
ATOM   2698 C C   . GLY A 1 385 ? 116.828 122.071 118.691 1.00 164.47 ?  385 GLY A C   1 
ATOM   2699 O O   . GLY A 1 385 ? 117.785 121.786 119.411 1.00 163.05 ?  385 GLY A O   1 
ATOM   2700 N N   . PHE A 1 386 ? 116.974 122.706 117.527 1.00 164.88 ?  386 PHE A N   1 
ATOM   2701 C CA  . PHE A 1 386 ? 118.286 123.121 117.042 1.00 166.76 ?  386 PHE A CA  1 
ATOM   2702 C C   . PHE A 1 386 ? 118.914 124.132 117.999 1.00 167.44 ?  386 PHE A C   1 
ATOM   2703 O O   . PHE A 1 386 ? 120.083 123.993 118.398 1.00 169.67 ?  386 PHE A O   1 
ATOM   2704 C CB  . PHE A 1 386 ? 118.107 123.708 115.637 1.00 164.74 ?  386 PHE A CB  1 
ATOM   2705 C CG  . PHE A 1 386 ? 119.381 124.098 114.938 1.00 164.43 ?  386 PHE A CG  1 
ATOM   2706 C CD1 . PHE A 1 386 ? 119.320 124.836 113.767 1.00 165.85 ?  386 PHE A CD1 1 
ATOM   2707 C CD2 . PHE A 1 386 ? 120.617 123.663 115.381 1.00 164.70 ?  386 PHE A CD2 1 
ATOM   2708 C CE1 . PHE A 1 386 ? 120.467 125.189 113.088 1.00 169.16 ?  386 PHE A CE1 1 
ATOM   2709 C CE2 . PHE A 1 386 ? 121.769 124.008 114.701 1.00 166.86 ?  386 PHE A CE2 1 
ATOM   2710 C CZ  . PHE A 1 386 ? 121.694 124.774 113.556 1.00 170.23 ?  386 PHE A CZ  1 
ATOM   2711 N N   . LEU A 1 387 ? 118.136 125.142 118.397 1.00 165.72 ?  387 LEU A N   1 
ATOM   2712 C CA  . LEU A 1 387 ? 118.632 126.153 119.324 1.00 168.24 ?  387 LEU A CA  1 
ATOM   2713 C C   . LEU A 1 387 ? 119.015 125.537 120.663 1.00 167.87 ?  387 LEU A C   1 
ATOM   2714 O O   . LEU A 1 387 ? 120.070 125.860 121.220 1.00 167.67 ?  387 LEU A O   1 
ATOM   2715 C CB  . LEU A 1 387 ? 117.581 127.250 119.513 1.00 166.38 ?  387 LEU A CB  1 
ATOM   2716 C CG  . LEU A 1 387 ? 117.781 128.285 120.625 1.00 166.83 ?  387 LEU A CG  1 
ATOM   2717 C CD1 . LEU A 1 387 ? 117.341 129.658 120.150 1.00 165.30 ?  387 LEU A CD1 1 
ATOM   2718 C CD2 . LEU A 1 387 ? 117.011 127.897 121.880 1.00 166.68 ?  387 LEU A CD2 1 
ATOM   2719 N N   . VAL A 1 388 ? 118.173 124.651 121.198 1.00 160.82 ?  388 VAL A N   1 
ATOM   2720 C CA  . VAL A 1 388 ? 118.484 124.015 122.475 1.00 161.68 ?  388 VAL A CA  1 
ATOM   2721 C C   . VAL A 1 388 ? 119.737 123.160 122.358 1.00 160.45 ?  388 VAL A C   1 
ATOM   2722 O O   . VAL A 1 388 ? 120.600 123.183 123.243 1.00 163.68 ?  388 VAL A O   1 
ATOM   2723 C CB  . VAL A 1 388 ? 117.281 123.194 122.973 1.00 162.75 ?  388 VAL A CB  1 
ATOM   2724 C CG1 . VAL A 1 388 ? 117.666 122.382 124.199 1.00 161.51 ?  388 VAL A CG1 1 
ATOM   2725 C CG2 . VAL A 1 388 ? 116.111 124.109 123.296 1.00 162.65 ?  388 VAL A CG2 1 
ATOM   2726 N N   . ILE A 1 389 ? 119.861 122.410 121.262 1.00 159.88 ?  389 ILE A N   1 
ATOM   2727 C CA  . ILE A 1 389 ? 121.006 121.527 121.066 1.00 165.31 ?  389 ILE A CA  1 
ATOM   2728 C C   . ILE A 1 389 ? 122.298 122.330 121.063 1.00 167.94 ?  389 ILE A C   1 
ATOM   2729 O O   . ILE A 1 389 ? 123.290 121.949 121.695 1.00 172.52 ?  389 ILE A O   1 
ATOM   2730 C CB  . ILE A 1 389 ? 120.839 120.714 119.769 1.00 165.20 ?  389 ILE A CB  1 
ATOM   2731 C CG1 . ILE A 1 389 ? 119.980 119.474 120.022 1.00 164.58 ?  389 ILE A CG1 1 
ATOM   2732 C CG2 . ILE A 1 389 ? 122.189 120.325 119.193 1.00 165.83 ?  389 ILE A CG2 1 
ATOM   2733 C CD1 . ILE A 1 389 ? 119.318 118.926 118.780 1.00 163.78 ?  389 ILE A CD1 1 
ATOM   2734 N N   . ASN A 1 390 ? 122.307 123.464 120.358 1.00 169.27 ?  390 ASN A N   1 
ATOM   2735 C CA  . ASN A 1 390 ? 123.529 124.265 120.329 1.00 168.90 ?  390 ASN A CA  1 
ATOM   2736 C C   . ASN A 1 390 ? 123.784 124.952 121.665 1.00 170.72 ?  390 ASN A C   1 
ATOM   2737 O O   . ASN A 1 390 ? 124.917 124.959 122.162 1.00 170.61 ?  390 ASN A O   1 
ATOM   2738 C CB  . ASN A 1 390 ? 123.480 125.297 119.206 1.00 170.16 ?  390 ASN A CB  1 
ATOM   2739 C CG  . ASN A 1 390 ? 123.531 124.667 117.840 1.00 172.28 ?  390 ASN A CG  1 
ATOM   2740 O OD1 . ASN A 1 390 ? 123.832 123.482 117.698 1.00 170.89 ?  390 ASN A OD1 1 
ATOM   2741 N ND2 . ASN A 1 390 ? 123.294 125.474 116.816 1.00 174.06 ?  390 ASN A ND2 1 
ATOM   2742 N N   . SER A 1 391 ? 122.746 125.535 122.268 1.00 171.71 ?  391 SER A N   1 
ATOM   2743 C CA  . SER A 1 391 ? 122.963 126.366 123.446 1.00 172.35 ?  391 SER A CA  1 
ATOM   2744 C C   . SER A 1 391 ? 123.189 125.526 124.697 1.00 173.52 ?  391 SER A C   1 
ATOM   2745 O O   . SER A 1 391 ? 124.275 125.564 125.286 1.00 173.76 ?  391 SER A O   1 
ATOM   2746 C CB  . SER A 1 391 ? 121.779 127.313 123.640 1.00 170.56 ?  391 SER A CB  1 
ATOM   2747 O OG  . SER A 1 391 ? 120.681 126.640 124.229 1.00 169.34 ?  391 SER A OG  1 
ATOM   2748 N N   . LEU A 1 392 ? 122.183 124.758 125.115 1.00 165.36 ?  392 LEU A N   1 
ATOM   2749 C CA  . LEU A 1 392 ? 122.242 124.045 126.386 1.00 163.31 ?  392 LEU A CA  1 
ATOM   2750 C C   . LEU A 1 392 ? 123.101 122.788 126.321 1.00 161.00 ?  392 LEU A C   1 
ATOM   2751 O O   . LEU A 1 392 ? 123.840 122.494 127.265 1.00 159.92 ?  392 LEU A O   1 
ATOM   2752 C CB  . LEU A 1 392 ? 120.827 123.685 126.852 1.00 162.63 ?  392 LEU A CB  1 
ATOM   2753 C CG  . LEU A 1 392 ? 120.551 123.871 128.346 1.00 165.69 ?  392 LEU A CG  1 
ATOM   2754 C CD1 . LEU A 1 392 ? 121.158 125.172 128.849 1.00 163.10 ?  392 LEU A CD1 1 
ATOM   2755 C CD2 . LEU A 1 392 ? 119.059 123.826 128.632 1.00 164.36 ?  392 LEU A CD2 1 
ATOM   2756 N N   . GLY A 1 393 ? 123.017 122.042 125.232 1.00 167.17 ?  393 GLY A N   1 
ATOM   2757 C CA  . GLY A 1 393 ? 123.768 120.810 125.103 1.00 168.44 ?  393 GLY A CA  1 
ATOM   2758 C C   . GLY A 1 393 ? 123.011 119.811 124.264 1.00 172.36 ?  393 GLY A C   1 
ATOM   2759 O O   . GLY A 1 393 ? 121.912 120.072 123.777 1.00 177.55 ?  393 GLY A O   1 
ATOM   2760 N N   . ARG A 1 394 ? 123.601 118.635 124.091 1.00 178.41 ?  394 ARG A N   1 
ATOM   2761 C CA  . ARG A 1 394 ? 122.936 117.590 123.334 1.00 177.53 ?  394 ARG A CA  1 
ATOM   2762 C C   . ARG A 1 394 ? 122.121 116.714 124.269 1.00 179.03 ?  394 ARG A C   1 
ATOM   2763 O O   . ARG A 1 394 ? 120.957 116.433 123.996 1.00 183.55 ?  394 ARG A O   1 
ATOM   2764 C CB  . ARG A 1 394 ? 123.955 116.740 122.598 1.00 179.10 ?  394 ARG A CB  1 
ATOM   2765 C CG  . ARG A 1 394 ? 125.090 117.530 121.980 1.00 182.63 ?  394 ARG A CG  1 
ATOM   2766 C CD  . ARG A 1 394 ? 124.684 118.137 120.652 1.00 181.06 ?  394 ARG A CD  1 
ATOM   2767 N NE  . ARG A 1 394 ? 125.840 118.689 119.957 1.00 184.01 ?  394 ARG A NE  1 
ATOM   2768 C CZ  . ARG A 1 394 ? 126.726 117.952 119.297 1.00 182.81 ?  394 ARG A CZ  1 
ATOM   2769 N NH1 . ARG A 1 394 ? 126.588 116.635 119.254 1.00 182.13 1  394 ARG A NH1 1 
ATOM   2770 N NH2 . ARG A 1 394 ? 127.754 118.528 118.691 1.00 181.34 ?  394 ARG A NH2 1 
ATOM   2771 N N   . ARG A 1 395 ? 122.718 116.282 125.376 1.00 166.67 ?  395 ARG A N   1 
ATOM   2772 C CA  . ARG A 1 395 ? 122.013 115.383 126.283 1.00 165.60 ?  395 ARG A CA  1 
ATOM   2773 C C   . ARG A 1 395 ? 120.832 116.080 126.961 1.00 166.85 ?  395 ARG A C   1 
ATOM   2774 O O   . ARG A 1 395 ? 119.749 115.481 127.061 1.00 166.16 ?  395 ARG A O   1 
ATOM   2775 C CB  . ARG A 1 395 ? 122.973 114.811 127.330 1.00 164.51 ?  395 ARG A CB  1 
ATOM   2776 C CG  . ARG A 1 395 ? 122.320 113.851 128.309 1.00 164.91 ?  395 ARG A CG  1 
ATOM   2777 C CD  . ARG A 1 395 ? 123.313 113.341 129.340 1.00 167.95 ?  395 ARG A CD  1 
ATOM   2778 N NE  . ARG A 1 395 ? 123.931 114.427 130.092 1.00 170.96 ?  395 ARG A NE  1 
ATOM   2779 C CZ  . ARG A 1 395 ? 124.929 114.270 130.951 1.00 169.14 ?  395 ARG A CZ  1 
ATOM   2780 N NH1 . ARG A 1 395 ? 125.443 113.077 131.202 1.00 167.44 1  395 ARG A NH1 1 
ATOM   2781 N NH2 . ARG A 1 395 ? 125.421 115.335 131.575 1.00 167.26 ?  395 ARG A NH2 1 
ATOM   2782 N N   . PRO A 1 396 ? 120.990 117.313 127.468 1.00 164.91 ?  396 PRO A N   1 
ATOM   2783 C CA  . PRO A 1 396 ? 119.816 118.003 128.025 1.00 163.27 ?  396 PRO A CA  1 
ATOM   2784 C C   . PRO A 1 396 ? 118.700 118.201 127.018 1.00 160.58 ?  396 PRO A C   1 
ATOM   2785 O O   . PRO A 1 396 ? 117.525 118.163 127.395 1.00 166.19 ?  396 PRO A O   1 
ATOM   2786 C CB  . PRO A 1 396 ? 120.396 119.340 128.504 1.00 165.38 ?  396 PRO A CB  1 
ATOM   2787 C CG  . PRO A 1 396 ? 121.804 119.031 128.814 1.00 166.09 ?  396 PRO A CG  1 
ATOM   2788 C CD  . PRO A 1 396 ? 122.225 118.074 127.743 1.00 165.39 ?  396 PRO A CD  1 
ATOM   2789 N N   . ALA A 1 397 ? 119.032 118.418 125.744 1.00 142.08 ?  397 ALA A N   1 
ATOM   2790 C CA  . ALA A 1 397 ? 117.991 118.576 124.733 1.00 145.34 ?  397 ALA A CA  1 
ATOM   2791 C C   . ALA A 1 397 ? 117.158 117.309 124.602 1.00 146.62 ?  397 ALA A C   1 
ATOM   2792 O O   . ALA A 1 397 ? 115.922 117.367 124.593 1.00 148.95 ?  397 ALA A O   1 
ATOM   2793 C CB  . ALA A 1 397 ? 118.614 118.948 123.389 1.00 146.73 ?  397 ALA A CB  1 
ATOM   2794 N N   . GLN A 1 398 ? 117.819 116.153 124.508 1.00 148.31 ?  398 GLN A N   1 
ATOM   2795 C CA  . GLN A 1 398 ? 117.098 114.888 124.431 1.00 151.15 ?  398 GLN A CA  1 
ATOM   2796 C C   . GLN A 1 398 ? 116.268 114.652 125.685 1.00 158.91 ?  398 GLN A C   1 
ATOM   2797 O O   . GLN A 1 398 ? 115.098 114.255 125.597 1.00 161.79 ?  398 GLN A O   1 
ATOM   2798 C CB  . GLN A 1 398 ? 118.082 113.739 124.224 1.00 147.28 ?  398 GLN A CB  1 
ATOM   2799 C CG  . GLN A 1 398 ? 117.440 112.440 123.787 1.00 147.38 ?  398 GLN A CG  1 
ATOM   2800 C CD  . GLN A 1 398 ? 116.828 112.539 122.411 1.00 153.04 ?  398 GLN A CD  1 
ATOM   2801 O OE1 . GLN A 1 398 ? 115.611 112.464 122.251 1.00 154.65 ?  398 GLN A OE1 1 
ATOM   2802 N NE2 . GLN A 1 398 ? 117.671 112.715 121.405 1.00 152.71 ?  398 GLN A NE2 1 
ATOM   2803 N N   . MET A 1 399 ? 116.858 114.895 126.860 1.00 166.43 ?  399 MET A N   1 
ATOM   2804 C CA  . MET A 1 399 ? 116.121 114.714 128.106 1.00 165.73 ?  399 MET A CA  1 
ATOM   2805 C C   . MET A 1 399 ? 114.861 115.566 128.134 1.00 164.81 ?  399 MET A C   1 
ATOM   2806 O O   . MET A 1 399 ? 113.764 115.057 128.396 1.00 154.50 ?  399 MET A O   1 
ATOM   2807 C CB  . MET A 1 399 ? 117.011 115.054 129.300 1.00 164.69 ?  399 MET A CB  1 
ATOM   2808 C CG  . MET A 1 399 ? 116.262 115.100 130.623 1.00 166.19 ?  399 MET A CG  1 
ATOM   2809 S SD  . MET A 1 399 ? 116.339 113.564 131.558 1.00 178.71 ?  399 MET A SD  1 
ATOM   2810 C CE  . MET A 1 399 ? 117.987 113.696 132.239 1.00 165.02 ?  399 MET A CE  1 
ATOM   2811 N N   . ALA A 1 400 ? 114.999 116.867 127.863 1.00 157.23 ?  400 ALA A N   1 
ATOM   2812 C CA  . ALA A 1 400 ? 113.856 117.768 127.923 1.00 151.23 ?  400 ALA A CA  1 
ATOM   2813 C C   . ALA A 1 400 ? 112.801 117.395 126.893 1.00 154.88 ?  400 ALA A C   1 
ATOM   2814 O O   . ALA A 1 400 ? 111.609 117.356 127.213 1.00 167.49 ?  400 ALA A O   1 
ATOM   2815 C CB  . ALA A 1 400 ? 114.312 119.212 127.725 1.00 149.21 ?  400 ALA A CB  1 
ATOM   2816 N N   . ALA A 1 401 ? 113.216 117.100 125.658 1.00 142.36 ?  401 ALA A N   1 
ATOM   2817 C CA  . ALA A 1 401 ? 112.244 116.766 124.622 1.00 148.49 ?  401 ALA A CA  1 
ATOM   2818 C C   . ALA A 1 401 ? 111.469 115.502 124.973 1.00 152.22 ?  401 ALA A C   1 
ATOM   2819 O O   . ALA A 1 401 ? 110.233 115.489 124.908 1.00 154.10 ?  401 ALA A O   1 
ATOM   2820 C CB  . ALA A 1 401 ? 112.946 116.614 123.275 1.00 145.72 ?  401 ALA A CB  1 
ATOM   2821 N N   . LEU A 1 402 ? 112.169 114.435 125.362 1.00 137.74 ?  402 LEU A N   1 
ATOM   2822 C CA  . LEU A 1 402 ? 111.486 113.193 125.697 1.00 141.01 ?  402 LEU A CA  1 
ATOM   2823 C C   . LEU A 1 402 ? 110.594 113.327 126.926 1.00 148.21 ?  402 LEU A C   1 
ATOM   2824 O O   . LEU A 1 402 ? 109.457 112.838 126.919 1.00 147.74 ?  402 LEU A O   1 
ATOM   2825 C CB  . LEU A 1 402 ? 112.508 112.075 125.906 1.00 136.43 ?  402 LEU A CB  1 
ATOM   2826 C CG  . LEU A 1 402 ? 113.094 111.500 124.616 1.00 135.61 ?  402 LEU A CG  1 
ATOM   2827 C CD1 . LEU A 1 402 ? 113.743 110.157 124.875 1.00 139.77 ?  402 LEU A CD1 1 
ATOM   2828 C CD2 . LEU A 1 402 ? 112.021 111.372 123.552 1.00 138.89 ?  402 LEU A CD2 1 
ATOM   2829 N N   . LEU A 1 403 ? 111.077 113.992 127.979 1.00 140.02 ?  403 LEU A N   1 
ATOM   2830 C CA  . LEU A 1 403 ? 110.276 114.142 129.188 1.00 139.43 ?  403 LEU A CA  1 
ATOM   2831 C C   . LEU A 1 403 ? 109.043 114.998 128.925 1.00 140.57 ?  403 LEU A C   1 
ATOM   2832 O O   . LEU A 1 403 ? 107.948 114.697 129.419 1.00 142.85 ?  403 LEU A O   1 
ATOM   2833 C CB  . LEU A 1 403 ? 111.137 114.735 130.305 1.00 137.81 ?  403 LEU A CB  1 
ATOM   2834 C CG  . LEU A 1 403 ? 110.490 115.177 131.617 1.00 138.39 ?  403 LEU A CG  1 
ATOM   2835 C CD1 . LEU A 1 403 ? 111.419 114.852 132.770 1.00 142.07 ?  403 LEU A CD1 1 
ATOM   2836 C CD2 . LEU A 1 403 ? 110.192 116.669 131.596 1.00 141.25 ?  403 LEU A CD2 1 
ATOM   2837 N N   . LEU A 1 404 ? 109.201 116.074 128.150 1.00 138.13 ?  404 LEU A N   1 
ATOM   2838 C CA  . LEU A 1 404 ? 108.060 116.911 127.805 1.00 134.11 ?  404 LEU A CA  1 
ATOM   2839 C C   . LEU A 1 404 ? 107.044 116.141 126.976 1.00 140.45 ?  404 LEU A C   1 
ATOM   2840 O O   . LEU A 1 404 ? 105.834 116.254 127.206 1.00 148.55 ?  404 LEU A O   1 
ATOM   2841 C CB  . LEU A 1 404 ? 108.537 118.155 127.060 1.00 132.24 ?  404 LEU A CB  1 
ATOM   2842 C CG  . LEU A 1 404 ? 107.511 119.275 126.909 1.00 139.93 ?  404 LEU A CG  1 
ATOM   2843 C CD1 . LEU A 1 404 ? 106.872 119.581 128.248 1.00 144.93 ?  404 LEU A CD1 1 
ATOM   2844 C CD2 . LEU A 1 404 ? 108.178 120.518 126.349 1.00 143.83 ?  404 LEU A CD2 1 
ATOM   2845 N N   . ALA A 1 405 ? 107.515 115.345 126.011 1.00 147.08 ?  405 ALA A N   1 
ATOM   2846 C CA  . ALA A 1 405 ? 106.596 114.521 125.234 1.00 153.02 ?  405 ALA A CA  1 
ATOM   2847 C C   . ALA A 1 405 ? 105.828 113.566 126.135 1.00 153.06 ?  405 ALA A C   1 
ATOM   2848 O O   . ALA A 1 405 ? 104.604 113.436 126.014 1.00 153.69 ?  405 ALA A O   1 
ATOM   2849 C CB  . ALA A 1 405 ? 107.359 113.747 124.160 1.00 148.62 ?  405 ALA A CB  1 
ATOM   2850 N N   . GLY A 1 406 ? 106.527 112.904 127.057 1.00 145.25 ?  406 GLY A N   1 
ATOM   2851 C CA  . GLY A 1 406 ? 105.859 111.964 127.942 1.00 152.40 ?  406 GLY A CA  1 
ATOM   2852 C C   . GLY A 1 406 ? 104.830 112.622 128.842 1.00 152.21 ?  406 GLY A C   1 
ATOM   2853 O O   . GLY A 1 406 ? 103.731 112.094 129.035 1.00 149.56 ?  406 GLY A O   1 
ATOM   2854 N N   . ILE A 1 407 ? 105.173 113.778 129.417 1.00 143.12 ?  407 ILE A N   1 
ATOM   2855 C CA  . ILE A 1 407 ? 104.237 114.460 130.307 1.00 141.61 ?  407 ILE A CA  1 
ATOM   2856 C C   . ILE A 1 407 ? 103.027 114.964 129.532 1.00 149.73 ?  407 ILE A C   1 
ATOM   2857 O O   . ILE A 1 407 ? 101.883 114.849 129.994 1.00 157.50 ?  407 ILE A O   1 
ATOM   2858 C CB  . ILE A 1 407 ? 104.944 115.594 131.070 1.00 141.16 ?  407 ILE A CB  1 
ATOM   2859 C CG1 . ILE A 1 407 ? 105.722 115.016 132.250 1.00 145.89 ?  407 ILE A CG1 1 
ATOM   2860 C CG2 . ILE A 1 407 ? 103.946 116.630 131.551 1.00 144.85 ?  407 ILE A CG2 1 
ATOM   2861 C CD1 . ILE A 1 407 ? 106.846 115.893 132.725 1.00 152.58 ?  407 ILE A CD1 1 
ATOM   2862 N N   . CYS A 1 408 ? 103.253 115.522 128.339 1.00 154.97 ?  408 CYS A N   1 
ATOM   2863 C CA  . CYS A 1 408 ? 102.133 115.929 127.501 1.00 156.62 ?  408 CYS A CA  1 
ATOM   2864 C C   . CYS A 1 408 ? 101.238 114.742 127.182 1.00 155.62 ?  408 CYS A C   1 
ATOM   2865 O O   . CYS A 1 408 ? 100.008 114.863 127.187 1.00 155.22 ?  408 CYS A O   1 
ATOM   2866 C CB  . CYS A 1 408 ? 102.644 116.567 126.212 1.00 156.18 ?  408 CYS A CB  1 
ATOM   2867 S SG  . CYS A 1 408 ? 103.304 118.227 126.417 1.00 168.95 ?  408 CYS A SG  1 
ATOM   2868 N N   . ILE A 1 409 ? 101.842 113.581 126.917 1.00 146.23 ?  409 ILE A N   1 
ATOM   2869 C CA  . ILE A 1 409 ? 101.067 112.402 126.553 1.00 149.16 ?  409 ILE A CA  1 
ATOM   2870 C C   . ILE A 1 409 ? 100.211 111.950 127.730 1.00 150.35 ?  409 ILE A C   1 
ATOM   2871 O O   . ILE A 1 409 ? 99.010  111.688 127.582 1.00 149.69 ?  409 ILE A O   1 
ATOM   2872 C CB  . ILE A 1 409 ? 102.007 111.275 126.098 1.00 144.43 ?  409 ILE A CB  1 
ATOM   2873 C CG1 . ILE A 1 409 ? 102.423 111.481 124.653 1.00 147.47 ?  409 ILE A CG1 1 
ATOM   2874 C CG2 . ILE A 1 409 ? 101.265 109.957 126.161 1.00 149.24 ?  409 ILE A CG2 1 
ATOM   2875 C CD1 . ILE A 1 409 ? 101.349 111.254 123.728 1.00 147.52 ?  409 ILE A CD1 1 
ATOM   2876 N N   . LEU A 1 410 ? 100.821 111.843 128.916 1.00 140.33 ?  410 LEU A N   1 
ATOM   2877 C CA  . LEU A 1 410 ? 100.069 111.438 130.100 1.00 140.85 ?  410 LEU A CA  1 
ATOM   2878 C C   . LEU A 1 410 ? 98.934  112.403 130.400 1.00 139.97 ?  410 LEU A C   1 
ATOM   2879 O O   . LEU A 1 410 ? 97.814  111.966 130.686 1.00 143.82 ?  410 LEU A O   1 
ATOM   2880 C CB  . LEU A 1 410 ? 100.980 111.329 131.327 1.00 145.31 ?  410 LEU A CB  1 
ATOM   2881 C CG  . LEU A 1 410 ? 101.687 110.008 131.641 1.00 146.45 ?  410 LEU A CG  1 
ATOM   2882 C CD1 . LEU A 1 410 ? 102.467 109.515 130.465 1.00 139.73 ?  410 LEU A CD1 1 
ATOM   2883 C CD2 . LEU A 1 410 ? 102.598 110.152 132.844 1.00 147.48 ?  410 LEU A CD2 1 
ATOM   2884 N N   . LEU A 1 411 ? 99.192  113.705 130.338 1.00 141.77 ?  411 LEU A N   1 
ATOM   2885 C CA  . LEU A 1 411 ? 98.140  114.672 130.602 1.00 145.44 ?  411 LEU A CA  1 
ATOM   2886 C C   . LEU A 1 411 ? 97.044  114.650 129.546 1.00 153.49 ?  411 LEU A C   1 
ATOM   2887 O O   . LEU A 1 411 ? 95.880  114.892 129.881 1.00 155.66 ?  411 LEU A O   1 
ATOM   2888 C CB  . LEU A 1 411 ? 98.738  116.073 130.714 1.00 142.53 ?  411 LEU A CB  1 
ATOM   2889 C CG  . LEU A 1 411 ? 99.455  116.368 132.031 1.00 147.18 ?  411 LEU A CG  1 
ATOM   2890 C CD1 . LEU A 1 411 ? 100.045 117.768 132.020 1.00 152.16 ?  411 LEU A CD1 1 
ATOM   2891 C CD2 . LEU A 1 411 ? 98.499  116.190 133.192 1.00 146.31 ?  411 LEU A CD2 1 
ATOM   2892 N N   . ASN A 1 412 ? 97.376  114.351 128.287 1.00 157.27 ?  412 ASN A N   1 
ATOM   2893 C CA  . ASN A 1 412 ? 96.335  114.118 127.293 1.00 157.47 ?  412 ASN A CA  1 
ATOM   2894 C C   . ASN A 1 412 ? 95.497  112.901 127.655 1.00 153.96 ?  412 ASN A C   1 
ATOM   2895 O O   . ASN A 1 412 ? 94.272  112.916 127.497 1.00 151.98 ?  412 ASN A O   1 
ATOM   2896 C CB  . ASN A 1 412 ? 96.951  113.942 125.905 1.00 155.80 ?  412 ASN A CB  1 
ATOM   2897 C CG  . ASN A 1 412 ? 95.909  113.921 124.804 1.00 151.58 ?  412 ASN A CG  1 
ATOM   2898 O OD1 . ASN A 1 412 ? 94.880  114.589 124.895 1.00 145.70 ?  412 ASN A OD1 1 
ATOM   2899 N ND2 . ASN A 1 412 ? 96.170  113.147 123.758 1.00 151.72 ?  412 ASN A ND2 1 
ATOM   2900 N N   . GLY A 1 413 ? 96.145  111.844 128.144 1.00 150.87 ?  413 GLY A N   1 
ATOM   2901 C CA  . GLY A 1 413 ? 95.406  110.665 128.562 1.00 150.47 ?  413 GLY A CA  1 
ATOM   2902 C C   . GLY A 1 413 ? 94.491  110.931 129.743 1.00 149.32 ?  413 GLY A C   1 
ATOM   2903 O O   . GLY A 1 413 ? 93.407  110.350 129.843 1.00 152.20 ?  413 GLY A O   1 
ATOM   2904 N N   . VAL A 1 414 ? 94.910  111.812 130.651 1.00 154.71 ?  414 VAL A N   1 
ATOM   2905 C CA  . VAL A 1 414 ? 94.141  112.045 131.871 1.00 156.16 ?  414 VAL A CA  1 
ATOM   2906 C C   . VAL A 1 414 ? 93.032  113.068 131.642 1.00 154.90 ?  414 VAL A C   1 
ATOM   2907 O O   . VAL A 1 414 ? 91.910  112.896 132.133 1.00 156.61 ?  414 VAL A O   1 
ATOM   2908 C CB  . VAL A 1 414 ? 95.082  112.469 133.013 1.00 158.80 ?  414 VAL A CB  1 
ATOM   2909 C CG1 . VAL A 1 414 ? 94.284  112.894 134.237 1.00 157.25 ?  414 VAL A CG1 1 
ATOM   2910 C CG2 . VAL A 1 414 ? 96.021  111.329 133.363 1.00 156.05 ?  414 VAL A CG2 1 
ATOM   2911 N N   . ILE A 1 415 ? 93.318  114.141 130.907 1.00 145.45 ?  415 ILE A N   1 
ATOM   2912 C CA  . ILE A 1 415 ? 92.315  115.196 130.715 1.00 148.29 ?  415 ILE A CA  1 
ATOM   2913 C C   . ILE A 1 415 ? 91.110  114.626 129.978 1.00 153.94 ?  415 ILE A C   1 
ATOM   2914 O O   . ILE A 1 415 ? 91.282  113.885 128.989 1.00 156.48 ?  415 ILE A O   1 
ATOM   2915 C CB  . ILE A 1 415 ? 92.918  116.390 129.953 1.00 147.69 ?  415 ILE A CB  1 
ATOM   2916 C CG1 . ILE A 1 415 ? 93.963  117.102 130.814 1.00 151.43 ?  415 ILE A CG1 1 
ATOM   2917 C CG2 . ILE A 1 415 ? 91.838  117.369 129.517 1.00 151.97 ?  415 ILE A CG2 1 
ATOM   2918 C CD1 . ILE A 1 415 ? 93.388  117.779 132.039 1.00 153.91 ?  415 ILE A CD1 1 
ATOM   2919 N N   . PRO A 1 416 ? 89.884  114.913 130.411 1.00 173.33 ?  416 PRO A N   1 
ATOM   2920 C CA  . PRO A 1 416 ? 88.709  114.342 129.747 1.00 172.70 ?  416 PRO A CA  1 
ATOM   2921 C C   . PRO A 1 416 ? 88.540  114.873 128.332 1.00 173.77 ?  416 PRO A C   1 
ATOM   2922 O O   . PRO A 1 416 ? 89.030  115.945 127.969 1.00 173.58 ?  416 PRO A O   1 
ATOM   2923 C CB  . PRO A 1 416 ? 87.543  114.777 130.643 1.00 171.51 ?  416 PRO A CB  1 
ATOM   2924 C CG  . PRO A 1 416 ? 88.172  115.149 131.948 1.00 172.05 ?  416 PRO A CG  1 
ATOM   2925 C CD  . PRO A 1 416 ? 89.517  115.693 131.603 1.00 172.65 ?  416 PRO A CD  1 
ATOM   2926 N N   . GLN A 1 417 ? 87.826  114.084 127.524 1.00 182.42 ?  417 GLN A N   1 
ATOM   2927 C CA  . GLN A 1 417 ? 87.620  114.414 126.119 1.00 181.90 ?  417 GLN A CA  1 
ATOM   2928 C C   . GLN A 1 417 ? 86.846  115.714 125.942 1.00 182.10 ?  417 GLN A C   1 
ATOM   2929 O O   . GLN A 1 417 ? 87.019  116.384 124.917 1.00 182.89 ?  417 GLN A O   1 
ATOM   2930 C CB  . GLN A 1 417 ? 86.944  113.210 125.431 1.00 182.73 ?  417 GLN A CB  1 
ATOM   2931 C CG  . GLN A 1 417 ? 86.669  113.254 123.906 1.00 182.71 ?  417 GLN A CG  1 
ATOM   2932 C CD  . GLN A 1 417 ? 85.625  114.262 123.431 1.00 183.61 ?  417 GLN A CD  1 
ATOM   2933 O OE1 . GLN A 1 417 ? 84.896  114.859 124.222 1.00 183.49 ?  417 GLN A OE1 1 
ATOM   2934 N NE2 . GLN A 1 417 ? 85.557  114.452 122.120 1.00 182.65 ?  417 GLN A NE2 1 
ATOM   2935 N N   . ASP A 1 418 ? 86.028  116.101 126.925 1.00 186.31 ?  418 ASP A N   1 
ATOM   2936 C CA  . ASP A 1 418 ? 85.219  117.309 126.790 1.00 187.25 ?  418 ASP A CA  1 
ATOM   2937 C C   . ASP A 1 418 ? 86.087  118.534 126.531 1.00 187.51 ?  418 ASP A C   1 
ATOM   2938 O O   . ASP A 1 418 ? 85.735  119.391 125.713 1.00 188.69 ?  418 ASP A O   1 
ATOM   2939 C CB  . ASP A 1 418 ? 84.366  117.511 128.041 1.00 186.79 ?  418 ASP A CB  1 
ATOM   2940 C CG  . ASP A 1 418 ? 83.541  116.290 128.384 1.00 187.58 ?  418 ASP A CG  1 
ATOM   2941 O OD1 . ASP A 1 418 ? 83.677  115.265 127.683 1.00 187.71 ?  418 ASP A OD1 1 
ATOM   2942 O OD2 . ASP A 1 418 ? 82.766  116.351 129.360 1.00 187.65 -1 418 ASP A OD2 1 
ATOM   2943 N N   . GLN A 1 419 ? 87.223  118.635 127.216 1.00 182.09 ?  419 GLN A N   1 
ATOM   2944 C CA  . GLN A 1 419 ? 88.185  119.695 126.943 1.00 182.85 ?  419 GLN A CA  1 
ATOM   2945 C C   . GLN A 1 419 ? 88.893  119.370 125.634 1.00 183.62 ?  419 GLN A C   1 
ATOM   2946 O O   . GLN A 1 419 ? 89.797  118.529 125.601 1.00 183.54 ?  419 GLN A O   1 
ATOM   2947 C CB  . GLN A 1 419 ? 89.180  119.826 128.093 1.00 182.51 ?  419 GLN A CB  1 
ATOM   2948 C CG  . GLN A 1 419 ? 88.553  120.200 129.426 1.00 181.52 ?  419 GLN A CG  1 
ATOM   2949 C CD  . GLN A 1 419 ? 88.068  121.635 129.464 1.00 184.86 ?  419 GLN A CD  1 
ATOM   2950 O OE1 . GLN A 1 419 ? 88.451  122.455 128.630 1.00 185.41 ?  419 GLN A OE1 1 
ATOM   2951 N NE2 . GLN A 1 419 ? 87.221  121.946 130.438 1.00 185.57 ?  419 GLN A NE2 1 
ATOM   2952 N N   . SER A 1 420 ? 88.481  120.028 124.552 1.00 170.07 ?  420 SER A N   1 
ATOM   2953 C CA  . SER A 1 420 ? 89.045  119.745 123.238 1.00 168.88 ?  420 SER A CA  1 
ATOM   2954 C C   . SER A 1 420 ? 90.309  120.547 122.959 1.00 168.96 ?  420 SER A C   1 
ATOM   2955 O O   . SER A 1 420 ? 91.291  119.994 122.449 1.00 167.56 ?  420 SER A O   1 
ATOM   2956 C CB  . SER A 1 420 ? 88.007  120.024 122.148 1.00 169.83 ?  420 SER A CB  1 
ATOM   2957 O OG  . SER A 1 420 ? 88.572  119.863 120.859 1.00 170.34 ?  420 SER A OG  1 
ATOM   2958 N N   . ILE A 1 421 ? 90.306  121.841 123.288 1.00 163.26 ?  421 ILE A N   1 
ATOM   2959 C CA  . ILE A 1 421 ? 91.462  122.679 122.989 1.00 163.71 ?  421 ILE A CA  1 
ATOM   2960 C C   . ILE A 1 421 ? 92.669  122.241 123.811 1.00 162.40 ?  421 ILE A C   1 
ATOM   2961 O O   . ILE A 1 421 ? 93.802  122.241 123.316 1.00 162.99 ?  421 ILE A O   1 
ATOM   2962 C CB  . ILE A 1 421 ? 91.116  124.169 123.193 1.00 162.94 ?  421 ILE A CB  1 
ATOM   2963 C CG1 . ILE A 1 421 ? 91.981  125.047 122.285 1.00 163.48 ?  421 ILE A CG1 1 
ATOM   2964 C CG2 . ILE A 1 421 ? 91.250  124.598 124.651 1.00 163.16 ?  421 ILE A CG2 1 
ATOM   2965 C CD1 . ILE A 1 421 ? 91.573  125.008 120.830 1.00 163.80 ?  421 ILE A CD1 1 
ATOM   2966 N N   . VAL A 1 422 ? 92.448  121.821 125.059 1.00 158.24 ?  422 VAL A N   1 
ATOM   2967 C CA  . VAL A 1 422 ? 93.559  121.384 125.898 1.00 160.25 ?  422 VAL A CA  1 
ATOM   2968 C C   . VAL A 1 422 ? 94.183  120.114 125.338 1.00 164.82 ?  422 VAL A C   1 
ATOM   2969 O O   . VAL A 1 422 ? 95.410  120.018 125.197 1.00 165.48 ?  422 VAL A O   1 
ATOM   2970 C CB  . VAL A 1 422 ? 93.087  121.190 127.349 1.00 156.28 ?  422 VAL A CB  1 
ATOM   2971 C CG1 . VAL A 1 422 ? 94.272  120.913 128.257 1.00 159.75 ?  422 VAL A CG1 1 
ATOM   2972 C CG2 . VAL A 1 422 ? 92.321  122.413 127.822 1.00 159.08 ?  422 VAL A CG2 1 
ATOM   2973 N N   . ARG A 1 423 ? 93.353  119.122 125.007 1.00 161.11 ?  423 ARG A N   1 
ATOM   2974 C CA  . ARG A 1 423 ? 93.870  117.874 124.456 1.00 159.20 ?  423 ARG A CA  1 
ATOM   2975 C C   . ARG A 1 423 ? 94.592  118.112 123.138 1.00 161.05 ?  423 ARG A C   1 
ATOM   2976 O O   . ARG A 1 423 ? 95.679  117.566 122.912 1.00 161.19 ?  423 ARG A O   1 
ATOM   2977 C CB  . ARG A 1 423 ? 92.730  116.875 124.267 1.00 157.25 ?  423 ARG A CB  1 
ATOM   2978 C CG  . ARG A 1 423 ? 92.151  116.346 125.566 1.00 162.31 ?  423 ARG A CG  1 
ATOM   2979 C CD  . ARG A 1 423 ? 91.140  115.239 125.318 1.00 162.74 ?  423 ARG A CD  1 
ATOM   2980 N NE  . ARG A 1 423 ? 91.772  113.931 125.203 1.00 164.23 ?  423 ARG A NE  1 
ATOM   2981 C CZ  . ARG A 1 423 ? 92.050  113.332 124.054 1.00 162.94 ?  423 ARG A CZ  1 
ATOM   2982 N NH1 . ARG A 1 423 ? 91.764  113.897 122.893 1.00 163.96 1  423 ARG A NH1 1 
ATOM   2983 N NH2 . ARG A 1 423 ? 92.627  112.134 124.070 1.00 161.60 ?  423 ARG A NH2 1 
ATOM   2984 N N   . THR A 1 424 ? 94.007  118.932 122.262 1.00 146.85 ?  424 THR A N   1 
ATOM   2985 C CA  . THR A 1 424 ? 94.637  119.221 120.978 1.00 142.03 ?  424 THR A CA  1 
ATOM   2986 C C   . THR A 1 424 ? 95.985  119.904 121.163 1.00 142.52 ?  424 THR A C   1 
ATOM   2987 O O   . THR A 1 424 ? 96.982  119.504 120.549 1.00 142.73 ?  424 THR A O   1 
ATOM   2988 C CB  . THR A 1 424 ? 93.710  120.086 120.126 1.00 140.67 ?  424 THR A CB  1 
ATOM   2989 O OG1 . THR A 1 424 ? 92.468  119.401 119.924 1.00 149.67 ?  424 THR A OG1 1 
ATOM   2990 C CG2 . THR A 1 424 ? 94.348  120.393 118.789 1.00 137.81 ?  424 THR A CG2 1 
ATOM   2991 N N   . SER A 1 425 ? 96.040  120.933 122.014 1.00 151.08 ?  425 SER A N   1 
ATOM   2992 C CA  . SER A 1 425 ? 97.290  121.655 122.219 1.00 149.99 ?  425 SER A CA  1 
ATOM   2993 C C   . SER A 1 425 ? 98.357  120.752 122.818 1.00 151.85 ?  425 SER A C   1 
ATOM   2994 O O   . SER A 1 425 ? 99.522  120.800 122.408 1.00 158.52 ?  425 SER A O   1 
ATOM   2995 C CB  . SER A 1 425 ? 97.051  122.870 123.115 1.00 149.32 ?  425 SER A CB  1 
ATOM   2996 O OG  . SER A 1 425 ? 96.097  123.745 122.541 1.00 152.91 ?  425 SER A OG  1 
ATOM   2997 N N   . LEU A 1 426 ? 97.980  119.916 123.786 1.00 138.29 ?  426 LEU A N   1 
ATOM   2998 C CA  . LEU A 1 426 ? 98.973  119.055 124.415 1.00 141.75 ?  426 LEU A CA  1 
ATOM   2999 C C   . LEU A 1 426 ? 99.472  117.974 123.465 1.00 144.14 ?  426 LEU A C   1 
ATOM   3000 O O   . LEU A 1 426 ? 100.671 117.675 123.450 1.00 146.95 ?  426 LEU A O   1 
ATOM   3001 C CB  . LEU A 1 426 ? 98.399  118.444 125.688 1.00 138.64 ?  426 LEU A CB  1 
ATOM   3002 C CG  . LEU A 1 426 ? 98.809  119.236 126.929 1.00 139.51 ?  426 LEU A CG  1 
ATOM   3003 C CD1 . LEU A 1 426 ? 97.927  120.458 127.113 1.00 140.69 ?  426 LEU A CD1 1 
ATOM   3004 C CD2 . LEU A 1 426 ? 98.756  118.359 128.149 1.00 140.57 ?  426 LEU A CD2 1 
ATOM   3005 N N   . ALA A 1 427 ? 98.586  117.390 122.653 1.00 124.16 ?  427 ALA A N   1 
ATOM   3006 C CA  . ALA A 1 427 ? 99.038  116.418 121.664 1.00 124.42 ?  427 ALA A CA  1 
ATOM   3007 C C   . ALA A 1 427 ? 99.934  117.073 120.620 1.00 124.90 ?  427 ALA A C   1 
ATOM   3008 O O   . ALA A 1 427 ? 100.912 116.468 120.164 1.00 128.23 ?  427 ALA A O   1 
ATOM   3009 C CB  . ALA A 1 427 ? 97.840  115.743 121.000 1.00 123.86 ?  427 ALA A CB  1 
ATOM   3010 N N   . VAL A 1 428 ? 99.617  118.309 120.231 1.00 116.95 ?  428 VAL A N   1 
ATOM   3011 C CA  . VAL A 1 428 ? 100.454 119.038 119.282 1.00 117.58 ?  428 VAL A CA  1 
ATOM   3012 C C   . VAL A 1 428 ? 101.840 119.281 119.863 1.00 120.40 ?  428 VAL A C   1 
ATOM   3013 O O   . VAL A 1 428 ? 102.862 119.089 119.187 1.00 119.95 ?  428 VAL A O   1 
ATOM   3014 C CB  . VAL A 1 428 ? 99.759  120.353 118.890 1.00 115.31 ?  428 VAL A CB  1 
ATOM   3015 C CG1 . VAL A 1 428 ? 100.767 121.382 118.419 1.00 120.94 ?  428 VAL A CG1 1 
ATOM   3016 C CG2 . VAL A 1 428 ? 98.717  120.084 117.829 1.00 112.43 ?  428 VAL A CG2 1 
ATOM   3017 N N   . LEU A 1 429 ? 101.898 119.711 121.124 1.00 128.96 ?  429 LEU A N   1 
ATOM   3018 C CA  . LEU A 1 429 ? 103.186 119.934 121.770 1.00 127.95 ?  429 LEU A CA  1 
ATOM   3019 C C   . LEU A 1 429 ? 103.969 118.633 121.878 1.00 127.46 ?  429 LEU A C   1 
ATOM   3020 O O   . LEU A 1 429 ? 105.190 118.615 121.682 1.00 128.05 ?  429 LEU A O   1 
ATOM   3021 C CB  . LEU A 1 429 ? 102.974 120.564 123.146 1.00 125.57 ?  429 LEU A CB  1 
ATOM   3022 C CG  . LEU A 1 429 ? 104.223 120.967 123.925 1.00 130.99 ?  429 LEU A CG  1 
ATOM   3023 C CD1 . LEU A 1 429 ? 105.044 121.949 123.115 1.00 133.73 ?  429 LEU A CD1 1 
ATOM   3024 C CD2 . LEU A 1 429 ? 103.833 121.575 125.259 1.00 130.19 ?  429 LEU A CD2 1 
ATOM   3025 N N   . GLY A 1 430 ? 103.281 117.530 122.178 1.00 139.77 ?  430 GLY A N   1 
ATOM   3026 C CA  . GLY A 1 430 ? 103.952 116.241 122.219 1.00 145.21 ?  430 GLY A CA  1 
ATOM   3027 C C   . GLY A 1 430 ? 104.521 115.833 120.875 1.00 146.31 ?  430 GLY A C   1 
ATOM   3028 O O   . GLY A 1 430 ? 105.641 115.324 120.794 1.00 156.22 ?  430 GLY A O   1 
ATOM   3029 N N   . LYS A 1 431 ? 103.760 116.048 119.800 1.00 113.86 ?  431 LYS A N   1 
ATOM   3030 C CA  . LYS A 1 431 ? 104.255 115.712 118.468 1.00 117.66 ?  431 LYS A CA  1 
ATOM   3031 C C   . LYS A 1 431 ? 105.468 116.559 118.102 1.00 126.63 ?  431 LYS A C   1 
ATOM   3032 O O   . LYS A 1 431 ? 106.437 116.051 117.522 1.00 129.68 ?  431 LYS A O   1 
ATOM   3033 C CB  . LYS A 1 431 ? 103.142 115.886 117.436 1.00 119.38 ?  431 LYS A CB  1 
ATOM   3034 C CG  . LYS A 1 431 ? 103.277 115.021 116.188 1.00 118.21 ?  431 LYS A CG  1 
ATOM   3035 C CD  . LYS A 1 431 ? 104.265 115.602 115.191 1.00 117.71 ?  431 LYS A CD  1 
ATOM   3036 C CE  . LYS A 1 431 ? 103.986 115.105 113.785 1.00 123.52 ?  431 LYS A CE  1 
ATOM   3037 N NZ  . LYS A 1 431 ? 105.004 115.590 112.816 1.00 122.07 1  431 LYS A NZ  1 
ATOM   3038 N N   . GLY A 1 432 ? 105.431 117.852 118.425 1.00 138.60 ?  432 GLY A N   1 
ATOM   3039 C CA  . GLY A 1 432 ? 106.589 118.693 118.165 1.00 141.61 ?  432 GLY A CA  1 
ATOM   3040 C C   . GLY A 1 432 ? 107.809 118.256 118.952 1.00 135.67 ?  432 GLY A C   1 
ATOM   3041 O O   . GLY A 1 432 ? 108.924 118.205 118.419 1.00 134.78 ?  432 GLY A O   1 
ATOM   3042 N N   . CYS A 1 433 ? 107.613 117.923 120.229 1.00 141.82 ?  433 CYS A N   1 
ATOM   3043 C CA  . CYS A 1 433 ? 108.718 117.434 121.042 1.00 144.44 ?  433 CYS A CA  1 
ATOM   3044 C C   . CYS A 1 433 ? 109.270 116.129 120.490 1.00 144.64 ?  433 CYS A C   1 
ATOM   3045 O O   . CYS A 1 433 ? 110.480 115.897 120.533 1.00 153.38 ?  433 CYS A O   1 
ATOM   3046 C CB  . CYS A 1 433 ? 108.265 117.260 122.489 1.00 148.31 ?  433 CYS A CB  1 
ATOM   3047 S SG  . CYS A 1 433 ? 107.882 118.811 123.315 1.00 161.50 ?  433 CYS A SG  1 
ATOM   3048 N N   . LEU A 1 434 ? 108.404 115.268 119.954 1.00 116.02 ?  434 LEU A N   1 
ATOM   3049 C CA  . LEU A 1 434 ? 108.886 114.006 119.405 1.00 116.03 ?  434 LEU A CA  1 
ATOM   3050 C C   . LEU A 1 434 ? 109.628 114.203 118.088 1.00 124.60 ?  434 LEU A C   1 
ATOM   3051 O O   . LEU A 1 434 ? 110.578 113.469 117.804 1.00 132.29 ?  434 LEU A O   1 
ATOM   3052 C CB  . LEU A 1 434 ? 107.728 113.028 119.232 1.00 116.94 ?  434 LEU A CB  1 
ATOM   3053 C CG  . LEU A 1 434 ? 107.227 112.440 120.552 1.00 117.32 ?  434 LEU A CG  1 
ATOM   3054 C CD1 . LEU A 1 434 ? 105.797 111.952 120.418 1.00 127.11 ?  434 LEU A CD1 1 
ATOM   3055 C CD2 . LEU A 1 434 ? 108.141 111.326 121.025 1.00 118.04 ?  434 LEU A CD2 1 
ATOM   3056 N N   . ALA A 1 435 ? 109.221 115.175 117.271 1.00 113.80 ?  435 ALA A N   1 
ATOM   3057 C CA  . ALA A 1 435 ? 110.009 115.489 116.080 1.00 112.40 ?  435 ALA A CA  1 
ATOM   3058 C C   . ALA A 1 435 ? 111.383 116.036 116.460 1.00 118.86 ?  435 ALA A C   1 
ATOM   3059 O O   . ALA A 1 435 ? 112.409 115.654 115.869 1.00 124.41 ?  435 ALA A O   1 
ATOM   3060 C CB  . ALA A 1 435 ? 109.259 116.484 115.198 1.00 111.24 ?  435 ALA A CB  1 
ATOM   3061 N N   . ALA A 1 436 ? 111.420 116.931 117.450 1.00 136.13 ?  436 ALA A N   1 
ATOM   3062 C CA  . ALA A 1 436 ? 112.701 117.412 117.951 1.00 138.17 ?  436 ALA A CA  1 
ATOM   3063 C C   . ALA A 1 436 ? 113.533 116.262 118.498 1.00 136.86 ?  436 ALA A C   1 
ATOM   3064 O O   . ALA A 1 436 ? 114.758 116.246 118.345 1.00 143.06 ?  436 ALA A O   1 
ATOM   3065 C CB  . ALA A 1 436 ? 112.484 118.477 119.024 1.00 141.98 ?  436 ALA A CB  1 
ATOM   3066 N N   . SER A 1 437 ? 112.879 115.253 119.050 1.00 136.33 ?  437 SER A N   1 
ATOM   3067 C CA  . SER A 1 437 ? 113.618 114.094 119.531 1.00 136.00 ?  437 SER A CA  1 
ATOM   3068 C C   . SER A 1 437 ? 114.184 113.275 118.379 1.00 136.62 ?  437 SER A C   1 
ATOM   3069 O O   . SER A 1 437 ? 115.307 112.791 118.460 1.00 144.53 ?  437 SER A O   1 
ATOM   3070 C CB  . SER A 1 437 ? 112.741 113.213 120.414 1.00 140.66 ?  437 SER A CB  1 
ATOM   3071 O OG  . SER A 1 437 ? 112.354 113.904 121.589 1.00 147.18 ?  437 SER A OG  1 
ATOM   3072 N N   . PHE A 1 438 ? 113.418 113.121 117.307 1.00 131.92 ?  438 PHE A N   1 
ATOM   3073 C CA  . PHE A 1 438 ? 113.883 112.330 116.177 1.00 133.75 ?  438 PHE A CA  1 
ATOM   3074 C C   . PHE A 1 438 ? 115.177 112.909 115.642 1.00 142.94 ?  438 PHE A C   1 
ATOM   3075 O O   . PHE A 1 438 ? 116.107 112.171 115.331 1.00 142.46 ?  438 PHE A O   1 
ATOM   3076 C CB  . PHE A 1 438 ? 112.840 112.278 115.068 1.00 133.81 ?  438 PHE A CB  1 
ATOM   3077 C CG  . PHE A 1 438 ? 112.002 111.039 115.085 1.00 136.50 ?  438 PHE A CG  1 
ATOM   3078 C CD1 . PHE A 1 438 ? 112.440 109.888 114.458 1.00 138.40 ?  438 PHE A CD1 1 
ATOM   3079 C CD2 . PHE A 1 438 ? 110.779 111.024 115.726 1.00 142.14 ?  438 PHE A CD2 1 
ATOM   3080 C CE1 . PHE A 1 438 ? 111.673 108.741 114.469 1.00 139.84 ?  438 PHE A CE1 1 
ATOM   3081 C CE2 . PHE A 1 438 ? 110.006 109.881 115.742 1.00 142.31 ?  438 PHE A CE2 1 
ATOM   3082 C CZ  . PHE A 1 438 ? 110.453 108.738 115.112 1.00 141.66 ?  438 PHE A CZ  1 
ATOM   3083 N N   . ASN A 1 439 ? 115.247 114.230 115.537 1.00 152.48 ?  439 ASN A N   1 
ATOM   3084 C CA  . ASN A 1 439 ? 116.477 114.867 115.088 1.00 144.74 ?  439 ASN A CA  1 
ATOM   3085 C C   . ASN A 1 439 ? 117.543 114.745 116.165 1.00 142.91 ?  439 ASN A C   1 
ATOM   3086 O O   . ASN A 1 439 ? 118.638 114.259 115.902 1.00 146.45 ?  439 ASN A O   1 
ATOM   3087 C CB  . ASN A 1 439 ? 116.241 116.332 114.733 1.00 144.14 ?  439 ASN A CB  1 
ATOM   3088 C CG  . ASN A 1 439 ? 115.280 116.500 113.576 1.00 148.11 ?  439 ASN A CG  1 
ATOM   3089 O OD1 . ASN A 1 439 ? 114.839 115.521 112.974 1.00 152.60 ?  439 ASN A OD1 1 
ATOM   3090 N ND2 . ASN A 1 439 ? 114.951 117.745 113.255 1.00 150.65 ?  439 ASN A ND2 1 
ATOM   3091 N N   . CYS A 1 440 ? 117.230 115.177 117.382 1.00 149.51 ?  440 CYS A N   1 
ATOM   3092 C CA  . CYS A 1 440 ? 118.249 115.142 118.420 1.00 150.36 ?  440 CYS A CA  1 
ATOM   3093 C C   . CYS A 1 440 ? 118.880 113.764 118.534 1.00 151.63 ?  440 CYS A C   1 
ATOM   3094 O O   . CYS A 1 440 ? 120.098 113.653 118.679 1.00 161.24 ?  440 CYS A O   1 
ATOM   3095 C CB  . CYS A 1 440 ? 117.648 115.571 119.757 1.00 153.55 ?  440 CYS A CB  1 
ATOM   3096 S SG  . CYS A 1 440 ? 118.856 115.820 121.075 1.00 157.05 ?  440 CYS A SG  1 
ATOM   3097 N N   . ILE A 1 441 ? 118.076 112.699 118.473 1.00 134.73 ?  441 ILE A N   1 
ATOM   3098 C CA  . ILE A 1 441 ? 118.631 111.358 118.569 1.00 136.69 ?  441 ILE A CA  1 
ATOM   3099 C C   . ILE A 1 441 ? 119.405 111.002 117.311 1.00 140.63 ?  441 ILE A C   1 
ATOM   3100 O O   . ILE A 1 441 ? 120.415 110.297 117.397 1.00 142.86 ?  441 ILE A O   1 
ATOM   3101 C CB  . ILE A 1 441 ? 117.537 110.312 118.868 1.00 141.45 ?  441 ILE A CB  1 
ATOM   3102 C CG1 . ILE A 1 441 ? 118.169 108.984 119.282 1.00 140.11 ?  441 ILE A CG1 1 
ATOM   3103 C CG2 . ILE A 1 441 ? 116.643 110.080 117.665 1.00 146.30 ?  441 ILE A CG2 1 
ATOM   3104 C CD1 . ILE A 1 441 ? 119.335 109.135 120.230 1.00 143.62 ?  441 ILE A CD1 1 
ATOM   3105 N N   . PHE A 1 442 ? 118.983 111.494 116.141 1.00 150.68 ?  442 PHE A N   1 
ATOM   3106 C CA  . PHE A 1 442 ? 119.787 111.292 114.942 1.00 155.94 ?  442 PHE A CA  1 
ATOM   3107 C C   . PHE A 1 442 ? 121.182 111.879 115.117 1.00 153.58 ?  442 PHE A C   1 
ATOM   3108 O O   . PHE A 1 442 ? 122.187 111.184 114.921 1.00 151.54 ?  442 PHE A O   1 
ATOM   3109 C CB  . PHE A 1 442 ? 119.089 111.909 113.729 1.00 151.45 ?  442 PHE A CB  1 
ATOM   3110 C CG  . PHE A 1 442 ? 119.798 111.661 112.428 1.00 148.99 ?  442 PHE A CG  1 
ATOM   3111 C CD1 . PHE A 1 442 ? 119.519 110.532 111.680 1.00 149.98 ?  442 PHE A CD1 1 
ATOM   3112 C CD2 . PHE A 1 442 ? 120.732 112.563 111.947 1.00 146.92 ?  442 PHE A CD2 1 
ATOM   3113 C CE1 . PHE A 1 442 ? 120.166 110.301 110.482 1.00 153.99 ?  442 PHE A CE1 1 
ATOM   3114 C CE2 . PHE A 1 442 ? 121.382 112.338 110.750 1.00 149.26 ?  442 PHE A CE2 1 
ATOM   3115 C CZ  . PHE A 1 442 ? 121.099 111.205 110.017 1.00 151.93 ?  442 PHE A CZ  1 
ATOM   3116 N N   . LEU A 1 443 ? 121.261 113.149 115.518 1.00 149.67 ?  443 LEU A N   1 
ATOM   3117 C CA  . LEU A 1 443 ? 122.569 113.782 115.679 1.00 144.56 ?  443 LEU A CA  1 
ATOM   3118 C C   . LEU A 1 443 ? 123.361 113.124 116.809 1.00 147.96 ?  443 LEU A C   1 
ATOM   3119 O O   . LEU A 1 443 ? 124.578 112.920 116.699 1.00 155.56 ?  443 LEU A O   1 
ATOM   3120 C CB  . LEU A 1 443 ? 122.389 115.286 115.913 1.00 146.91 ?  443 LEU A CB  1 
ATOM   3121 C CG  . LEU A 1 443 ? 123.552 116.218 116.271 1.00 150.59 ?  443 LEU A CG  1 
ATOM   3122 C CD1 . LEU A 1 443 ? 123.152 117.650 115.966 1.00 151.14 ?  443 LEU A CD1 1 
ATOM   3123 C CD2 . LEU A 1 443 ? 123.955 116.114 117.728 1.00 148.05 ?  443 LEU A CD2 1 
ATOM   3124 N N   . TYR A 1 444 ? 122.679 112.782 117.905 1.00 161.48 ?  444 TYR A N   1 
ATOM   3125 C CA  . TYR A 1 444 ? 123.338 112.174 119.054 1.00 161.26 ?  444 TYR A CA  1 
ATOM   3126 C C   . TYR A 1 444 ? 123.969 110.841 118.684 1.00 163.11 ?  444 TYR A C   1 
ATOM   3127 O O   . TYR A 1 444 ? 125.120 110.571 119.043 1.00 168.53 ?  444 TYR A O   1 
ATOM   3128 C CB  . TYR A 1 444 ? 122.324 111.988 120.183 1.00 161.50 ?  444 TYR A CB  1 
ATOM   3129 C CG  . TYR A 1 444 ? 122.868 112.179 121.578 1.00 159.20 ?  444 TYR A CG  1 
ATOM   3130 C CD1 . TYR A 1 444 ? 123.168 113.442 122.064 1.00 160.33 ?  444 TYR A CD1 1 
ATOM   3131 C CD2 . TYR A 1 444 ? 123.063 111.094 122.418 1.00 162.22 ?  444 TYR A CD2 1 
ATOM   3132 C CE1 . TYR A 1 444 ? 123.657 113.614 123.346 1.00 164.30 ?  444 TYR A CE1 1 
ATOM   3133 C CE2 . TYR A 1 444 ? 123.552 111.259 123.696 1.00 166.14 ?  444 TYR A CE2 1 
ATOM   3134 C CZ  . TYR A 1 444 ? 123.847 112.520 124.156 1.00 167.65 ?  444 TYR A CZ  1 
ATOM   3135 O OH  . TYR A 1 444 ? 124.335 112.684 125.431 1.00 170.62 ?  444 TYR A OH  1 
ATOM   3136 N N   . THR A 1 445 ? 123.237 109.996 117.959 1.00 152.75 ?  445 THR A N   1 
ATOM   3137 C CA  . THR A 1 445 ? 123.772 108.710 117.543 1.00 155.17 ?  445 THR A CA  1 
ATOM   3138 C C   . THR A 1 445 ? 124.743 108.829 116.379 1.00 153.29 ?  445 THR A C   1 
ATOM   3139 O O   . THR A 1 445 ? 125.499 107.885 116.128 1.00 157.65 ?  445 THR A O   1 
ATOM   3140 C CB  . THR A 1 445 ? 122.629 107.758 117.181 1.00 154.98 ?  445 THR A CB  1 
ATOM   3141 O OG1 . THR A 1 445 ? 123.052 106.404 117.384 1.00 160.64 ?  445 THR A OG1 1 
ATOM   3142 C CG2 . THR A 1 445 ? 122.201 107.946 115.737 1.00 154.67 ?  445 THR A CG2 1 
ATOM   3143 N N   . GLY A 1 446 ? 124.744 109.954 115.668 1.00 147.57 ?  446 GLY A N   1 
ATOM   3144 C CA  . GLY A 1 446 ? 125.776 110.192 114.682 1.00 151.35 ?  446 GLY A CA  1 
ATOM   3145 C C   . GLY A 1 446 ? 127.091 110.584 115.317 1.00 153.01 ?  446 GLY A C   1 
ATOM   3146 O O   . GLY A 1 446 ? 128.164 110.281 114.788 1.00 152.25 ?  446 GLY A O   1 
ATOM   3147 N N   . GLU A 1 447 ? 127.055 111.226 116.474 1.00 167.35 ?  447 GLU A N   1 
ATOM   3148 C CA  . GLU A 1 447 ? 128.297 111.689 117.079 1.00 163.70 ?  447 GLU A CA  1 
ATOM   3149 C C   . GLU A 1 447 ? 128.761 110.772 118.199 1.00 164.84 ?  447 GLU A C   1 
ATOM   3150 O O   . GLU A 1 447 ? 129.899 110.864 118.649 1.00 168.74 ?  447 GLU A O   1 
ATOM   3151 C CB  . GLU A 1 447 ? 128.133 113.117 117.596 1.00 165.30 ?  447 GLU A CB  1 
ATOM   3152 C CG  . GLU A 1 447 ? 129.348 113.677 118.311 1.00 169.04 ?  447 GLU A CG  1 
ATOM   3153 C CD  . GLU A 1 447 ? 129.240 115.166 118.550 1.00 171.52 ?  447 GLU A CD  1 
ATOM   3154 O OE1 . GLU A 1 447 ? 129.869 115.663 119.505 1.00 170.08 ?  447 GLU A OE1 1 
ATOM   3155 O OE2 . GLU A 1 447 ? 128.521 115.839 117.783 1.00 172.34 -1 447 GLU A OE2 1 
ATOM   3156 N N   . LEU A 1 448 ? 127.895 109.873 118.646 1.00 160.91 ?  448 LEU A N   1 
ATOM   3157 C CA  . LEU A 1 448 ? 128.266 109.030 119.780 1.00 160.24 ?  448 LEU A CA  1 
ATOM   3158 C C   . LEU A 1 448 ? 129.117 107.836 119.364 1.00 164.80 ?  448 LEU A C   1 
ATOM   3159 O O   . LEU A 1 448 ? 130.116 107.528 120.024 1.00 169.89 ?  448 LEU A O   1 
ATOM   3160 C CB  . LEU A 1 448 ? 127.011 108.548 120.506 1.00 163.65 ?  448 LEU A CB  1 
ATOM   3161 C CG  . LEU A 1 448 ? 126.555 109.375 121.707 1.00 168.62 ?  448 LEU A CG  1 
ATOM   3162 C CD1 . LEU A 1 448 ? 125.573 108.587 122.553 1.00 168.89 ?  448 LEU A CD1 1 
ATOM   3163 C CD2 . LEU A 1 448 ? 127.756 109.780 122.539 1.00 167.00 ?  448 LEU A CD2 1 
ATOM   3164 N N   . TYR A 1 449 ? 128.740 107.151 118.288 1.00 170.07 ?  449 TYR A N   1 
ATOM   3165 C CA  . TYR A 1 449 ? 129.420 105.927 117.897 1.00 170.03 ?  449 TYR A CA  1 
ATOM   3166 C C   . TYR A 1 449 ? 130.825 106.217 117.371 1.00 175.33 ?  449 TYR A C   1 
ATOM   3167 O O   . TYR A 1 449 ? 131.073 107.278 116.792 1.00 181.37 ?  449 TYR A O   1 
ATOM   3168 C CB  . TYR A 1 449 ? 128.624 105.195 116.823 1.00 167.52 ?  449 TYR A CB  1 
ATOM   3169 C CG  . TYR A 1 449 ? 127.486 104.355 117.351 1.00 170.03 ?  449 TYR A CG  1 
ATOM   3170 C CD1 . TYR A 1 449 ? 127.724 103.283 118.197 1.00 174.17 ?  449 TYR A CD1 1 
ATOM   3171 C CD2 . TYR A 1 449 ? 126.175 104.627 116.993 1.00 169.30 ?  449 TYR A CD2 1 
ATOM   3172 C CE1 . TYR A 1 449 ? 126.688 102.511 118.678 1.00 174.29 ?  449 TYR A CE1 1 
ATOM   3173 C CE2 . TYR A 1 449 ? 125.132 103.862 117.470 1.00 170.12 ?  449 TYR A CE2 1 
ATOM   3174 C CZ  . TYR A 1 449 ? 125.394 102.804 118.310 1.00 171.94 ?  449 TYR A CZ  1 
ATOM   3175 O OH  . TYR A 1 449 ? 124.357 102.037 118.786 1.00 174.17 ?  449 TYR A OH  1 
ATOM   3176 N N   . PRO A 1 450 ? 131.760 105.290 117.563 1.00 188.36 ?  450 PRO A N   1 
ATOM   3177 C CA  . PRO A 1 450 ? 133.075 105.428 116.932 1.00 188.31 ?  450 PRO A CA  1 
ATOM   3178 C C   . PRO A 1 450 ? 132.965 105.331 115.419 1.00 189.60 ?  450 PRO A C   1 
ATOM   3179 O O   . PRO A 1 450 ? 132.026 104.749 114.872 1.00 189.51 ?  450 PRO A O   1 
ATOM   3180 C CB  . PRO A 1 450 ? 133.873 104.252 117.506 1.00 188.89 ?  450 PRO A CB  1 
ATOM   3181 C CG  . PRO A 1 450 ? 133.159 103.895 118.766 1.00 189.08 ?  450 PRO A CG  1 
ATOM   3182 C CD  . PRO A 1 450 ? 131.710 104.128 118.463 1.00 188.67 ?  450 PRO A CD  1 
ATOM   3183 N N   . THR A 1 451 ? 133.955 105.918 114.741 1.00 195.24 ?  451 THR A N   1 
ATOM   3184 C CA  . THR A 1 451 ? 133.916 105.997 113.283 1.00 196.65 ?  451 THR A CA  1 
ATOM   3185 C C   . THR A 1 451 ? 133.895 104.614 112.642 1.00 198.97 ?  451 THR A C   1 
ATOM   3186 O O   . THR A 1 451 ? 133.321 104.431 111.562 1.00 198.41 ?  451 THR A O   1 
ATOM   3187 C CB  . THR A 1 451 ? 135.113 106.799 112.770 1.00 195.99 ?  451 THR A CB  1 
ATOM   3188 O OG1 . THR A 1 451 ? 135.285 107.970 113.576 1.00 196.37 ?  451 THR A OG1 1 
ATOM   3189 C CG2 . THR A 1 451 ? 134.887 107.221 111.329 1.00 195.94 ?  451 THR A CG2 1 
ATOM   3190 N N   . MET A 1 452 ? 134.514 103.628 113.293 1.00 203.97 ?  452 MET A N   1 
ATOM   3191 C CA  . MET A 1 452 ? 134.532 102.276 112.743 1.00 203.21 ?  452 MET A CA  1 
ATOM   3192 C C   . MET A 1 452 ? 133.124 101.704 112.650 1.00 203.89 ?  452 MET A C   1 
ATOM   3193 O O   . MET A 1 452 ? 132.754 101.090 111.643 1.00 204.87 ?  452 MET A O   1 
ATOM   3194 C CB  . MET A 1 452 ? 135.419 101.375 113.601 1.00 201.19 ?  452 MET A CB  1 
ATOM   3195 C CG  . MET A 1 452 ? 136.897 101.314 113.206 1.00 202.01 ?  452 MET A CG  1 
ATOM   3196 S SD  . MET A 1 452 ? 137.290 101.422 111.442 1.00 203.81 ?  452 MET A SD  1 
ATOM   3197 C CE  . MET A 1 452 ? 137.398 103.194 111.163 1.00 201.92 ?  452 MET A CE  1 
ATOM   3198 N N   . ILE A 1 453 ? 132.321 101.910 113.687 1.00 187.81 ?  453 ILE A N   1 
ATOM   3199 C CA  . ILE A 1 453 ? 130.995 101.320 113.787 1.00 185.85 ?  453 ILE A CA  1 
ATOM   3200 C C   . ILE A 1 453 ? 129.902 102.377 113.619 1.00 186.10 ?  453 ILE A C   1 
ATOM   3201 O O   . ILE A 1 453 ? 128.725 102.094 113.832 1.00 190.17 ?  453 ILE A O   1 
ATOM   3202 C CB  . ILE A 1 453 ? 130.846 100.547 115.109 1.00 187.39 ?  453 ILE A CB  1 
ATOM   3203 C CG1 . ILE A 1 453 ? 129.791 99.445  114.987 1.00 190.97 ?  453 ILE A CG1 1 
ATOM   3204 C CG2 . ILE A 1 453 ? 130.548 101.491 116.264 1.00 190.94 ?  453 ILE A CG2 1 
ATOM   3205 C CD1 . ILE A 1 453 ? 130.237 98.268  114.161 1.00 190.26 ?  453 ILE A CD1 1 
ATOM   3206 N N   . ARG A 1 454 ? 130.276 103.590 113.205 1.00 177.60 ?  454 ARG A N   1 
ATOM   3207 C CA  . ARG A 1 454 ? 129.327 104.698 113.155 1.00 181.40 ?  454 ARG A CA  1 
ATOM   3208 C C   . ARG A 1 454 ? 128.167 104.440 112.204 1.00 183.16 ?  454 ARG A C   1 
ATOM   3209 O O   . ARG A 1 454 ? 127.012 104.688 112.568 1.00 185.08 ?  454 ARG A O   1 
ATOM   3210 C CB  . ARG A 1 454 ? 130.046 105.983 112.750 1.00 181.52 ?  454 ARG A CB  1 
ATOM   3211 C CG  . ARG A 1 454 ? 129.203 107.236 112.874 1.00 180.06 ?  454 ARG A CG  1 
ATOM   3212 C CD  . ARG A 1 454 ? 130.076 108.462 112.731 1.00 181.51 ?  454 ARG A CD  1 
ATOM   3213 N NE  . ARG A 1 454 ? 131.085 108.512 113.781 1.00 182.07 ?  454 ARG A NE  1 
ATOM   3214 C CZ  . ARG A 1 454 ? 132.265 109.103 113.660 1.00 180.81 ?  454 ARG A CZ  1 
ATOM   3215 N NH1 . ARG A 1 454 ? 132.627 109.699 112.537 1.00 179.74 1  454 ARG A NH1 1 
ATOM   3216 N NH2 . ARG A 1 454 ? 133.105 109.089 114.691 1.00 181.14 ?  454 ARG A NH2 1 
ATOM   3217 N N   . GLN A 1 455 ? 128.441 103.947 110.997 1.00 174.15 ?  455 GLN A N   1 
ATOM   3218 C CA  . GLN A 1 455 ? 127.362 103.726 110.041 1.00 171.67 ?  455 GLN A CA  1 
ATOM   3219 C C   . GLN A 1 455 ? 126.469 102.565 110.457 1.00 170.10 ?  455 GLN A C   1 
ATOM   3220 O O   . GLN A 1 455 ? 125.240 102.664 110.367 1.00 172.82 ?  455 GLN A O   1 
ATOM   3221 C CB  . GLN A 1 455 ? 127.934 103.484 108.646 1.00 171.51 ?  455 GLN A CB  1 
ATOM   3222 C CG  . GLN A 1 455 ? 127.046 103.998 107.524 1.00 172.70 ?  455 GLN A CG  1 
ATOM   3223 C CD  . GLN A 1 455 ? 126.879 105.505 107.550 1.00 174.87 ?  455 GLN A CD  1 
ATOM   3224 O OE1 . GLN A 1 455 ? 127.690 106.223 108.136 1.00 173.91 ?  455 GLN A OE1 1 
ATOM   3225 N NE2 . GLN A 1 455 ? 125.819 105.993 106.917 1.00 173.04 ?  455 GLN A NE2 1 
ATOM   3226 N N   . THR A 1 456 ? 127.064 101.459 110.908 1.00 166.37 ?  456 THR A N   1 
ATOM   3227 C CA  . THR A 1 456 ? 126.263 100.338 111.387 1.00 167.34 ?  456 THR A CA  1 
ATOM   3228 C C   . THR A 1 456 ? 125.400 100.759 112.569 1.00 167.12 ?  456 THR A C   1 
ATOM   3229 O O   . THR A 1 456 ? 124.218 100.402 112.645 1.00 168.02 ?  456 THR A O   1 
ATOM   3230 C CB  . THR A 1 456 ? 127.169 99.166  111.763 1.00 168.67 ?  456 THR A CB  1 
ATOM   3231 O OG1 . THR A 1 456 ? 127.835 98.684  110.589 1.00 168.64 ?  456 THR A OG1 1 
ATOM   3232 C CG2 . THR A 1 456 ? 126.358 98.033  112.372 1.00 166.84 ?  456 THR A CG2 1 
ATOM   3233 N N   . GLY A 1 457 ? 125.970 101.538 113.490 1.00 166.67 ?  457 GLY A N   1 
ATOM   3234 C CA  . GLY A 1 457 ? 125.171 102.109 114.558 1.00 167.55 ?  457 GLY A CA  1 
ATOM   3235 C C   . GLY A 1 457 ? 124.078 103.023 114.049 1.00 168.70 ?  457 GLY A C   1 
ATOM   3236 O O   . GLY A 1 457 ? 123.022 103.142 114.677 1.00 175.10 ?  457 GLY A O   1 
ATOM   3237 N N   . MET A 1 458 ? 124.311 103.681 112.914 1.00 160.74 ?  458 MET A N   1 
ATOM   3238 C CA  . MET A 1 458 ? 123.247 104.434 112.263 1.00 161.29 ?  458 MET A CA  1 
ATOM   3239 C C   . MET A 1 458 ? 122.125 103.511 111.813 1.00 161.09 ?  458 MET A C   1 
ATOM   3240 O O   . MET A 1 458 ? 120.946 103.870 111.904 1.00 159.39 ?  458 MET A O   1 
ATOM   3241 C CB  . MET A 1 458 ? 123.798 105.207 111.063 1.00 165.46 ?  458 MET A CB  1 
ATOM   3242 C CG  . MET A 1 458 ? 123.084 106.524 110.771 1.00 164.20 ?  458 MET A CG  1 
ATOM   3243 S SD  . MET A 1 458 ? 123.016 107.704 112.134 1.00 169.24 ?  458 MET A SD  1 
ATOM   3244 C CE  . MET A 1 458 ? 124.632 107.483 112.873 1.00 167.12 ?  458 MET A CE  1 
ATOM   3245 N N   . GLY A 1 459 ? 122.476 102.324 111.315 1.00 155.14 ?  459 GLY A N   1 
ATOM   3246 C CA  . GLY A 1 459 ? 121.458 101.408 110.835 1.00 153.02 ?  459 GLY A CA  1 
ATOM   3247 C C   . GLY A 1 459 ? 120.630 100.812 111.956 1.00 154.77 ?  459 GLY A C   1 
ATOM   3248 O O   . GLY A 1 459 ? 119.420 101.049 112.035 1.00 158.53 ?  459 GLY A O   1 
ATOM   3249 N N   . MET A 1 460 ? 121.273 100.059 112.855 1.00 143.99 ?  460 MET A N   1 
ATOM   3250 C CA  . MET A 1 460 ? 120.533 99.339  113.889 1.00 146.76 ?  460 MET A CA  1 
ATOM   3251 C C   . MET A 1 460 ? 119.664 100.279 114.712 1.00 150.24 ?  460 MET A C   1 
ATOM   3252 O O   . MET A 1 460 ? 118.485 99.989  114.950 1.00 152.76 ?  460 MET A O   1 
ATOM   3253 C CB  . MET A 1 460 ? 121.493 98.570  114.793 1.00 144.63 ?  460 MET A CB  1 
ATOM   3254 C CG  . MET A 1 460 ? 122.358 97.557  114.072 1.00 148.09 ?  460 MET A CG  1 
ATOM   3255 S SD  . MET A 1 460 ? 121.443 96.079  113.596 1.00 152.47 ?  460 MET A SD  1 
ATOM   3256 C CE  . MET A 1 460 ? 122.200 94.853  114.660 1.00 147.01 ?  460 MET A CE  1 
ATOM   3257 N N   . GLY A 1 461 ? 120.217 101.418 115.136 1.00 149.19 ?  461 GLY A N   1 
ATOM   3258 C CA  . GLY A 1 461 ? 119.400 102.393 115.838 1.00 146.32 ?  461 GLY A CA  1 
ATOM   3259 C C   . GLY A 1 461 ? 118.165 102.773 115.045 1.00 153.78 ?  461 GLY A C   1 
ATOM   3260 O O   . GLY A 1 461 ? 117.039 102.651 115.538 1.00 161.56 ?  461 GLY A O   1 
ATOM   3261 N N   . SER A 1 462 ? 118.352 103.153 113.778 1.00 138.63 ?  462 SER A N   1 
ATOM   3262 C CA  . SER A 1 462 ? 117.202 103.422 112.925 1.00 135.59 ?  462 SER A CA  1 
ATOM   3263 C C   . SER A 1 462 ? 116.306 102.199 112.818 1.00 133.64 ?  462 SER A C   1 
ATOM   3264 O O   . SER A 1 462 ? 115.077 102.325 112.890 1.00 133.01 ?  462 SER A O   1 
ATOM   3265 C CB  . SER A 1 462 ? 117.661 103.867 111.539 1.00 137.57 ?  462 SER A CB  1 
ATOM   3266 O OG  . SER A 1 462 ? 116.553 104.235 110.737 1.00 138.82 ?  462 SER A OG  1 
ATOM   3267 N N   . THR A 1 463 ? 116.904 101.011 112.688 1.00 127.29 ?  463 THR A N   1 
ATOM   3268 C CA  . THR A 1 463 ? 116.108 99.791  112.650 1.00 128.75 ?  463 THR A CA  1 
ATOM   3269 C C   . THR A 1 463 ? 115.241 99.679  113.894 1.00 132.34 ?  463 THR A C   1 
ATOM   3270 O O   . THR A 1 463 ? 114.046 99.372  113.798 1.00 141.31 ?  463 THR A O   1 
ATOM   3271 C CB  . THR A 1 463 ? 117.014 98.568  112.511 1.00 127.91 ?  463 THR A CB  1 
ATOM   3272 O OG1 . THR A 1 463 ? 117.602 98.556  111.205 1.00 132.93 ?  463 THR A OG1 1 
ATOM   3273 C CG2 . THR A 1 463 ? 116.220 97.289  112.708 1.00 123.01 ?  463 THR A CG2 1 
ATOM   3274 N N   . MET A 1 464 ? 115.811 99.978  115.067 1.00 134.63 ?  464 MET A N   1 
ATOM   3275 C CA  . MET A 1 464 ? 115.009 99.944  116.283 1.00 134.80 ?  464 MET A CA  1 
ATOM   3276 C C   . MET A 1 464 ? 113.799 100.855 116.164 1.00 135.72 ?  464 MET A C   1 
ATOM   3277 O O   . MET A 1 464 ? 112.689 100.456 116.539 1.00 143.22 ?  464 MET A O   1 
ATOM   3278 C CB  . MET A 1 464 ? 115.857 100.331 117.492 1.00 136.73 ?  464 MET A CB  1 
ATOM   3279 C CG  . MET A 1 464 ? 116.938 99.331  117.939 1.00 142.26 ?  464 MET A CG  1 
ATOM   3280 S SD  . MET A 1 464 ? 116.531 97.567  118.058 1.00 158.74 ?  464 MET A SD  1 
ATOM   3281 C CE  . MET A 1 464 ? 116.642 96.988  116.365 1.00 140.62 ?  464 MET A CE  1 
ATOM   3282 N N   . ALA A 1 465 ? 113.985 102.054 115.603 1.00 118.68 ?  465 ALA A N   1 
ATOM   3283 C CA  . ALA A 1 465 ? 112.854 102.944 115.374 1.00 125.43 ?  465 ALA A CA  1 
ATOM   3284 C C   . ALA A 1 465 ? 111.756 102.238 114.595 1.00 132.91 ?  465 ALA A C   1 
ATOM   3285 O O   . ALA A 1 465 ? 110.590 102.242 115.011 1.00 130.79 ?  465 ALA A O   1 
ATOM   3286 C CB  . ALA A 1 465 ? 113.314 104.199 114.634 1.00 120.43 ?  465 ALA A CB  1 
ATOM   3287 N N   . ARG A 1 466 ? 112.119 101.578 113.492 1.00 129.37 ?  466 ARG A N   1 
ATOM   3288 C CA  . ARG A 1 466 ? 111.122 100.845 112.725 1.00 123.96 ?  466 ARG A CA  1 
ATOM   3289 C C   . ARG A 1 466 ? 110.473 99.757  113.565 1.00 122.67 ?  466 ARG A C   1 
ATOM   3290 O O   . ARG A 1 466 ? 109.249 99.588  113.511 1.00 130.94 ?  466 ARG A O   1 
ATOM   3291 C CB  . ARG A 1 466 ? 111.755 100.260 111.465 1.00 121.17 ?  466 ARG A CB  1 
ATOM   3292 C CG  . ARG A 1 466 ? 112.032 101.300 110.393 1.00 121.73 ?  466 ARG A CG  1 
ATOM   3293 C CD  . ARG A 1 466 ? 112.842 100.723 109.248 1.00 127.68 ?  466 ARG A CD  1 
ATOM   3294 N NE  . ARG A 1 466 ? 114.261 100.634 109.565 1.00 135.95 ?  466 ARG A NE  1 
ATOM   3295 C CZ  . ARG A 1 466 ? 115.177 101.484 109.124 1.00 131.32 ?  466 ARG A CZ  1 
ATOM   3296 N NH1 . ARG A 1 466 ? 114.856 102.495 108.333 1.00 128.49 1  466 ARG A NH1 1 
ATOM   3297 N NH2 . ARG A 1 466 ? 116.447 101.313 109.480 1.00 127.04 ?  466 ARG A NH2 1 
ATOM   3298 N N   . VAL A 1 467 ? 111.262 99.045  114.376 1.00 106.83 ?  467 VAL A N   1 
ATOM   3299 C CA  . VAL A 1 467 ? 110.678 98.051  115.269 1.00 108.18 ?  467 VAL A CA  1 
ATOM   3300 C C   . VAL A 1 467 ? 109.658 98.708  116.182 1.00 110.97 ?  467 VAL A C   1 
ATOM   3301 O O   . VAL A 1 467 ? 108.568 98.163  116.401 1.00 115.50 ?  467 VAL A O   1 
ATOM   3302 C CB  . VAL A 1 467 ? 111.773 97.329  116.072 1.00 111.89 ?  467 VAL A CB  1 
ATOM   3303 C CG1 . VAL A 1 467 ? 111.151 96.472  117.157 1.00 108.99 ?  467 VAL A CG1 1 
ATOM   3304 C CG2 . VAL A 1 467 ? 112.619 96.478  115.150 1.00 120.86 ?  467 VAL A CG2 1 
ATOM   3305 N N   . GLY A 1 468 ? 109.968 99.899  116.695 1.00 114.46 ?  468 GLY A N   1 
ATOM   3306 C CA  . GLY A 1 468 ? 108.990 100.617 117.490 1.00 118.57 ?  468 GLY A CA  1 
ATOM   3307 C C   . GLY A 1 468 ? 107.699 100.848 116.732 1.00 119.74 ?  468 GLY A C   1 
ATOM   3308 O O   . GLY A 1 468 ? 106.607 100.633 117.265 1.00 119.46 ?  468 GLY A O   1 
ATOM   3309 N N   . SER A 1 469 ? 107.804 101.243 115.462 1.00 115.20 ?  469 SER A N   1 
ATOM   3310 C CA  . SER A 1 469 ? 106.599 101.524 114.692 1.00 124.20 ?  469 SER A CA  1 
ATOM   3311 C C   . SER A 1 469 ? 105.852 100.244 114.346 1.00 121.69 ?  469 SER A C   1 
ATOM   3312 O O   . SER A 1 469 ? 104.716 100.295 113.863 1.00 120.87 ?  469 SER A O   1 
ATOM   3313 C CB  . SER A 1 469 ? 106.937 102.296 113.422 1.00 121.90 ?  469 SER A CB  1 
ATOM   3314 O OG  . SER A 1 469 ? 105.821 102.295 112.550 1.00 119.26 ?  469 SER A OG  1 
ATOM   3315 N N   . ILE A 1 470 ? 106.484 99.087  114.546 1.00 125.43 ?  470 ILE A N   1 
ATOM   3316 C CA  . ILE A 1 470 ? 105.755 97.832  114.398 1.00 119.09 ?  470 ILE A CA  1 
ATOM   3317 C C   . ILE A 1 470 ? 104.989 97.517  115.676 1.00 125.10 ?  470 ILE A C   1 
ATOM   3318 O O   . ILE A 1 470 ? 103.914 96.908  115.639 1.00 125.99 ?  470 ILE A O   1 
ATOM   3319 C CB  . ILE A 1 470 ? 106.713 96.694  114.001 1.00 116.42 ?  470 ILE A CB  1 
ATOM   3320 C CG1 . ILE A 1 470 ? 107.317 96.971  112.625 1.00 115.13 ?  470 ILE A CG1 1 
ATOM   3321 C CG2 . ILE A 1 470 ? 105.995 95.356  113.983 1.00 111.86 ?  470 ILE A CG2 1 
ATOM   3322 C CD1 . ILE A 1 470 ? 108.409 96.009  112.239 1.00 117.51 ?  470 ILE A CD1 1 
ATOM   3323 N N   . VAL A 1 471 ? 105.515 97.947  116.822 1.00 129.29 ?  471 VAL A N   1 
ATOM   3324 C CA  . VAL A 1 471 ? 104.834 97.673  118.081 1.00 127.38 ?  471 VAL A CA  1 
ATOM   3325 C C   . VAL A 1 471 ? 103.781 98.738  118.380 1.00 131.73 ?  471 VAL A C   1 
ATOM   3326 O O   . VAL A 1 471 ? 102.811 98.470  119.099 1.00 131.32 ?  471 VAL A O   1 
ATOM   3327 C CB  . VAL A 1 471 ? 105.866 97.552  119.215 1.00 123.20 ?  471 VAL A CB  1 
ATOM   3328 C CG1 . VAL A 1 471 ? 105.193 97.224  120.537 1.00 125.69 ?  471 VAL A CG1 1 
ATOM   3329 C CG2 . VAL A 1 471 ? 106.895 96.492  118.872 1.00 126.18 ?  471 VAL A CG2 1 
ATOM   3330 N N   . SER A 1 472 ? 103.934 99.943  117.826 1.00 129.48 ?  472 SER A N   1 
ATOM   3331 C CA  . SER A 1 472 ? 103.022 101.034 118.168 1.00 132.36 ?  472 SER A CA  1 
ATOM   3332 C C   . SER A 1 472 ? 101.569 100.739 117.814 1.00 134.64 ?  472 SER A C   1 
ATOM   3333 O O   . SER A 1 472 ? 100.703 100.909 118.690 1.00 135.63 ?  472 SER A O   1 
ATOM   3334 C CB  . SER A 1 472 ? 103.508 102.334 117.518 1.00 126.52 ?  472 SER A CB  1 
ATOM   3335 O OG  . SER A 1 472 ? 102.470 103.298 117.478 1.00 127.09 ?  472 SER A OG  1 
ATOM   3336 N N   . PRO A 1 473 ? 101.218 100.321 116.592 1.00 132.19 ?  473 PRO A N   1 
ATOM   3337 C CA  . PRO A 1 473 ? 99.811  99.971  116.339 1.00 138.92 ?  473 PRO A CA  1 
ATOM   3338 C C   . PRO A 1 473 ? 99.309  98.817  117.187 1.00 142.40 ?  473 PRO A C   1 
ATOM   3339 O O   . PRO A 1 473 ? 98.143  98.829  117.600 1.00 145.66 ?  473 PRO A O   1 
ATOM   3340 C CB  . PRO A 1 473 ? 99.801  99.618  114.846 1.00 140.47 ?  473 PRO A CB  1 
ATOM   3341 C CG  . PRO A 1 473 ? 100.971 100.323 114.284 1.00 134.70 ?  473 PRO A CG  1 
ATOM   3342 C CD  . PRO A 1 473 ? 102.011 100.263 115.353 1.00 127.90 ?  473 PRO A CD  1 
ATOM   3343 N N   . LEU A 1 474 ? 100.146 97.806  117.360 1.00 139.40 ?  474 LEU A N   1 
ATOM   3344 C CA  . LEU A 1 474 ? 99.717  96.626  118.084 1.00 139.63 ?  474 LEU A CA  1 
ATOM   3345 C C   . LEU A 1 474 ? 99.313  96.974  119.512 1.00 147.63 ?  474 LEU A C   1 
ATOM   3346 O O   . LEU A 1 474 ? 98.246  96.579  119.969 1.00 152.27 ?  474 LEU A O   1 
ATOM   3347 C CB  . LEU A 1 474 ? 100.820 95.573  118.062 1.00 137.20 ?  474 LEU A CB  1 
ATOM   3348 C CG  . LEU A 1 474 ? 101.277 95.194  116.656 1.00 138.73 ?  474 LEU A CG  1 
ATOM   3349 C CD1 . LEU A 1 474 ? 102.392 94.163  116.714 1.00 147.58 ?  474 LEU A CD1 1 
ATOM   3350 C CD2 . LEU A 1 474 ? 100.101 94.674  115.846 1.00 135.98 ?  474 LEU A CD2 1 
ATOM   3351 N N   . VAL A 1 475 ? 100.146 97.731  120.211 1.00 132.08 ?  475 VAL A N   1 
ATOM   3352 C CA  . VAL A 1 475 ? 99.791  98.119  121.559 1.00 132.11 ?  475 VAL A CA  1 
ATOM   3353 C C   . VAL A 1 475 ? 98.487  98.894  121.509 1.00 134.64 ?  475 VAL A C   1 
ATOM   3354 O O   . VAL A 1 475 ? 97.689  98.833  122.439 1.00 135.43 ?  475 VAL A O   1 
ATOM   3355 C CB  . VAL A 1 475 ? 100.877 98.963  122.234 1.00 127.54 ?  475 VAL A CB  1 
ATOM   3356 C CG1 . VAL A 1 475 ? 102.200 98.218  122.231 1.00 129.92 ?  475 VAL A CG1 1 
ATOM   3357 C CG2 . VAL A 1 475 ? 101.017 100.308 121.550 1.00 127.36 ?  475 VAL A CG2 1 
ATOM   3358 N N   . SER A 1 476 ? 98.258  99.611  120.416 1.00 137.89 ?  476 SER A N   1 
ATOM   3359 C CA  . SER A 1 476 ? 97.027  100.378 120.279 1.00 139.83 ?  476 SER A CA  1 
ATOM   3360 C C   . SER A 1 476 ? 95.836  99.450  120.348 1.00 140.78 ?  476 SER A C   1 
ATOM   3361 O O   . SER A 1 476 ? 94.784  99.817  120.864 1.00 146.10 ?  476 SER A O   1 
ATOM   3362 C CB  . SER A 1 476 ? 97.006  101.151 118.964 1.00 136.62 ?  476 SER A CB  1 
ATOM   3363 O OG  . SER A 1 476 ? 95.790  101.858 118.811 1.00 136.42 ?  476 SER A OG  1 
ATOM   3364 N N   . MET A 1 477 ? 96.001  98.237  119.843 1.00 150.50 ?  477 MET A N   1 
ATOM   3365 C CA  . MET A 1 477 ? 94.903  97.284  119.835 1.00 153.94 ?  477 MET A CA  1 
ATOM   3366 C C   . MET A 1 477 ? 94.397  97.034  121.240 1.00 157.12 ?  477 MET A C   1 
ATOM   3367 O O   . MET A 1 477 ? 93.251  96.635  121.425 1.00 161.84 ?  477 MET A O   1 
ATOM   3368 C CB  . MET A 1 477 ? 95.353  95.967  119.207 1.00 151.52 ?  477 MET A CB  1 
ATOM   3369 C CG  . MET A 1 477 ? 95.917  96.112  117.804 1.00 154.77 ?  477 MET A CG  1 
ATOM   3370 S SD  . MET A 1 477 ? 96.705  94.602  117.218 1.00 163.54 ?  477 MET A SD  1 
ATOM   3371 C CE  . MET A 1 477 ? 95.368  93.428  117.406 1.00 155.02 ?  477 MET A CE  1 
ATOM   3372 N N   . THR A 1 478 ? 95.241  97.259  122.236 1.00 153.32 ?  478 THR A N   1 
ATOM   3373 C CA  . THR A 1 478 ? 94.849  96.965  123.607 1.00 156.44 ?  478 THR A CA  1 
ATOM   3374 C C   . THR A 1 478 ? 93.769  97.912  124.107 1.00 154.11 ?  478 THR A C   1 
ATOM   3375 O O   . THR A 1 478 ? 93.281  97.765  125.224 1.00 155.48 ?  478 THR A O   1 
ATOM   3376 C CB  . THR A 1 478 ? 96.055  97.041  124.553 1.00 158.32 ?  478 THR A CB  1 
ATOM   3377 O OG1 . THR A 1 478 ? 97.235  96.613  123.862 1.00 156.72 ?  478 THR A OG1 1 
ATOM   3378 C CG2 . THR A 1 478 ? 95.833  96.151  125.758 1.00 158.04 ?  478 THR A CG2 1 
ATOM   3379 N N   . ALA A 1 479 ? 93.380  98.878  123.286 1.00 155.67 ?  479 ALA A N   1 
ATOM   3380 C CA  . ALA A 1 479 ? 92.401  99.863  123.728 1.00 159.63 ?  479 ALA A CA  1 
ATOM   3381 C C   . ALA A 1 479 ? 91.133  99.203  124.240 1.00 163.20 ?  479 ALA A C   1 
ATOM   3382 O O   . ALA A 1 479 ? 90.613  99.586  125.285 1.00 163.34 ?  479 ALA A O   1 
ATOM   3383 C CB  . ALA A 1 479 ? 92.068  100.816 122.595 1.00 160.67 ?  479 ALA A CB  1 
ATOM   3384 N N   . GLU A 1 480 ? 90.632  98.215  123.507 1.00 179.93 ?  480 GLU A N   1 
ATOM   3385 C CA  . GLU A 1 480 ? 89.400  97.538  123.898 1.00 180.05 ?  480 GLU A CA  1 
ATOM   3386 C C   . GLU A 1 480 ? 89.392  97.238  125.385 1.00 180.82 ?  480 GLU A C   1 
ATOM   3387 O O   . GLU A 1 480 ? 88.330  97.150  125.997 1.00 182.18 ?  480 GLU A O   1 
ATOM   3388 C CB  . GLU A 1 480 ? 89.226  96.245  123.103 1.00 180.70 ?  480 GLU A CB  1 
ATOM   3389 C CG  . GLU A 1 480 ? 89.003  96.438  121.609 1.00 179.61 ?  480 GLU A CG  1 
ATOM   3390 C CD  . GLU A 1 480 ? 90.279  96.751  120.848 1.00 180.26 ?  480 GLU A CD  1 
ATOM   3391 O OE1 . GLU A 1 480 ? 90.716  95.898  120.048 1.00 177.51 ?  480 GLU A OE1 1 
ATOM   3392 O OE2 . GLU A 1 480 ? 90.847  97.846  121.044 1.00 182.89 -1 480 GLU A OE2 1 
ATOM   3393 N N   . LEU A 1 481 ? 90.569  97.079  125.970 1.00 183.94 ?  481 LEU A N   1 
ATOM   3394 C CA  . LEU A 1 481 ? 90.679  96.815  127.402 1.00 183.89 ?  481 LEU A CA  1 
ATOM   3395 C C   . LEU A 1 481 ? 90.402  98.074  128.212 1.00 182.92 ?  481 LEU A C   1 
ATOM   3396 O O   . LEU A 1 481 ? 89.586  98.064  129.141 1.00 183.84 ?  481 LEU A O   1 
ATOM   3397 C CB  . LEU A 1 481 ? 92.064  96.254  127.733 1.00 182.14 ?  481 LEU A CB  1 
ATOM   3398 C CG  . LEU A 1 481 ? 92.667  95.119  126.897 1.00 183.22 ?  481 LEU A CG  1 
ATOM   3399 C CD1 . LEU A 1 481 ? 93.653  94.334  127.743 1.00 183.54 ?  481 LEU A CD1 1 
ATOM   3400 C CD2 . LEU A 1 481 ? 91.598  94.178  126.358 1.00 181.77 ?  481 LEU A CD2 1 
ATOM   3401 N N   . TYR A 1 482 ? 91.057  99.173  127.846 1.00 187.05 ?  482 TYR A N   1 
ATOM   3402 C CA  . TYR A 1 482 ? 90.842  100.445 128.541 1.00 189.85 ?  482 TYR A CA  1 
ATOM   3403 C C   . TYR A 1 482 ? 91.041  101.617 127.588 1.00 189.97 ?  482 TYR A C   1 
ATOM   3404 O O   . TYR A 1 482 ? 92.070  101.704 126.922 1.00 189.77 ?  482 TYR A O   1 
ATOM   3405 C CB  . TYR A 1 482 ? 91.786  100.574 129.732 1.00 190.81 ?  482 TYR A CB  1 
ATOM   3406 C CG  . TYR A 1 482 ? 91.855  99.331  130.586 1.00 193.11 ?  482 TYR A CG  1 
ATOM   3407 C CD1 . TYR A 1 482 ? 90.951  99.124  131.618 1.00 192.30 ?  482 TYR A CD1 1 
ATOM   3408 C CD2 . TYR A 1 482 ? 92.817  98.359  130.352 1.00 192.17 ?  482 TYR A CD2 1 
ATOM   3409 C CE1 . TYR A 1 482 ? 91.007  97.985  132.397 1.00 194.08 ?  482 TYR A CE1 1 
ATOM   3410 C CE2 . TYR A 1 482 ? 92.880  97.217  131.125 1.00 192.10 ?  482 TYR A CE2 1 
ATOM   3411 C CZ  . TYR A 1 482 ? 91.973  97.036  132.146 1.00 193.97 ?  482 TYR A CZ  1 
ATOM   3412 O OH  . TYR A 1 482 ? 92.033  95.901  132.921 1.00 191.51 ?  482 TYR A OH  1 
ATOM   3413 N N   . PRO A 1 483 ? 90.058  102.525 127.514 1.00 181.66 ?  483 PRO A N   1 
ATOM   3414 C CA  . PRO A 1 483 ? 90.151  103.624 126.542 1.00 180.41 ?  483 PRO A CA  1 
ATOM   3415 C C   . PRO A 1 483 ? 91.449  104.407 126.615 1.00 178.71 ?  483 PRO A C   1 
ATOM   3416 O O   . PRO A 1 483 ? 91.940  104.866 125.577 1.00 178.73 ?  483 PRO A O   1 
ATOM   3417 C CB  . PRO A 1 483 ? 88.954  104.513 126.910 1.00 179.96 ?  483 PRO A CB  1 
ATOM   3418 C CG  . PRO A 1 483 ? 88.016  103.637 127.711 1.00 179.21 ?  483 PRO A CG  1 
ATOM   3419 C CD  . PRO A 1 483 ? 88.671  102.304 127.951 1.00 178.95 ?  483 PRO A CD  1 
ATOM   3420 N N   . SER A 1 484 ? 92.021  104.579 127.805 1.00 171.06 ?  484 SER A N   1 
ATOM   3421 C CA  . SER A 1 484 ? 93.184  105.437 127.986 1.00 172.92 ?  484 SER A CA  1 
ATOM   3422 C C   . SER A 1 484 ? 94.488  104.668 128.157 1.00 175.19 ?  484 SER A C   1 
ATOM   3423 O O   . SER A 1 484 ? 95.544  105.296 128.284 1.00 176.36 ?  484 SER A O   1 
ATOM   3424 C CB  . SER A 1 484 ? 92.972  106.358 129.192 1.00 172.85 ?  484 SER A CB  1 
ATOM   3425 O OG  . SER A 1 484 ? 92.017  107.363 128.901 1.00 175.79 ?  484 SER A OG  1 
ATOM   3426 N N   . MET A 1 485 ? 94.446  103.336 128.173 1.00 160.18 ?  485 MET A N   1 
ATOM   3427 C CA  . MET A 1 485 ? 95.678  102.564 128.326 1.00 156.26 ?  485 MET A CA  1 
ATOM   3428 C C   . MET A 1 485 ? 96.687  102.794 127.204 1.00 154.98 ?  485 MET A C   1 
ATOM   3429 O O   . MET A 1 485 ? 97.887  102.929 127.514 1.00 162.00 ?  485 MET A O   1 
ATOM   3430 C CB  . MET A 1 485 ? 95.344  101.072 128.461 1.00 155.17 ?  485 MET A CB  1 
ATOM   3431 C CG  . MET A 1 485 ? 96.404  100.143 127.895 1.00 157.15 ?  485 MET A CG  1 
ATOM   3432 S SD  . MET A 1 485 ? 96.385  98.512  128.661 1.00 170.99 ?  485 MET A SD  1 
ATOM   3433 C CE  . MET A 1 485 ? 97.804  97.754  127.875 1.00 156.92 ?  485 MET A CE  1 
ATOM   3434 N N   . PRO A 1 486 ? 96.307  102.820 125.916 1.00 139.38 ?  486 PRO A N   1 
ATOM   3435 C CA  . PRO A 1 486 ? 97.320  103.089 124.883 1.00 143.99 ?  486 PRO A CA  1 
ATOM   3436 C C   . PRO A 1 486 ? 98.056  104.397 125.092 1.00 151.33 ?  486 PRO A C   1 
ATOM   3437 O O   . PRO A 1 486 ? 99.279  104.439 124.937 1.00 157.41 ?  486 PRO A O   1 
ATOM   3438 C CB  . PRO A 1 486 ? 96.499  103.103 123.587 1.00 142.16 ?  486 PRO A CB  1 
ATOM   3439 C CG  . PRO A 1 486 ? 95.344  102.239 123.875 1.00 147.29 ?  486 PRO A CG  1 
ATOM   3440 C CD  . PRO A 1 486 ? 95.006  102.477 125.315 1.00 146.17 ?  486 PRO A CD  1 
ATOM   3441 N N   . LEU A 1 487 ? 97.352  105.464 125.472 1.00 143.64 ?  487 LEU A N   1 
ATOM   3442 C CA  . LEU A 1 487 ? 98.035  106.723 125.751 1.00 143.33 ?  487 LEU A CA  1 
ATOM   3443 C C   . LEU A 1 487 ? 98.936  106.598 126.973 1.00 146.78 ?  487 LEU A C   1 
ATOM   3444 O O   . LEU A 1 487 ? 100.044 107.150 127.000 1.00 152.18 ?  487 LEU A O   1 
ATOM   3445 C CB  . LEU A 1 487 ? 97.013  107.842 125.944 1.00 138.85 ?  487 LEU A CB  1 
ATOM   3446 C CG  . LEU A 1 487 ? 96.381  108.397 124.668 1.00 141.95 ?  487 LEU A CG  1 
ATOM   3447 C CD1 . LEU A 1 487 ? 95.174  109.256 125.000 1.00 152.10 ?  487 LEU A CD1 1 
ATOM   3448 C CD2 . LEU A 1 487 ? 97.397  109.188 123.866 1.00 136.45 ?  487 LEU A CD2 1 
ATOM   3449 N N   . PHE A 1 488 ? 98.480  105.866 127.993 1.00 140.95 ?  488 PHE A N   1 
ATOM   3450 C CA  . PHE A 1 488 ? 99.282  105.718 129.199 1.00 138.73 ?  488 PHE A CA  1 
ATOM   3451 C C   . PHE A 1 488 ? 100.608 105.032 128.906 1.00 141.06 ?  488 PHE A C   1 
ATOM   3452 O O   . PHE A 1 488 ? 101.653 105.485 129.382 1.00 142.87 ?  488 PHE A O   1 
ATOM   3453 C CB  . PHE A 1 488 ? 98.498  104.954 130.263 1.00 138.29 ?  488 PHE A CB  1 
ATOM   3454 C CG  . PHE A 1 488 ? 97.697  105.842 131.170 1.00 143.72 ?  488 PHE A CG  1 
ATOM   3455 C CD1 . PHE A 1 488 ? 97.609  105.579 132.526 1.00 145.88 ?  488 PHE A CD1 1 
ATOM   3456 C CD2 . PHE A 1 488 ? 97.033  106.946 130.663 1.00 147.23 ?  488 PHE A CD2 1 
ATOM   3457 C CE1 . PHE A 1 488 ? 96.872  106.401 133.357 1.00 150.01 ?  488 PHE A CE1 1 
ATOM   3458 C CE2 . PHE A 1 488 ? 96.295  107.771 131.487 1.00 149.47 ?  488 PHE A CE2 1 
ATOM   3459 C CZ  . PHE A 1 488 ? 96.214  107.499 132.836 1.00 152.69 ?  488 PHE A CZ  1 
ATOM   3460 N N   . ILE A 1 489 ? 100.600 103.960 128.112 1.00 135.63 ?  489 ILE A N   1 
ATOM   3461 C CA  . ILE A 1 489 ? 101.864 103.320 127.751 1.00 137.39 ?  489 ILE A CA  1 
ATOM   3462 C C   . ILE A 1 489 ? 102.663 104.199 126.789 1.00 136.74 ?  489 ILE A C   1 
ATOM   3463 O O   . ILE A 1 489 ? 103.894 104.307 126.897 1.00 141.42 ?  489 ILE A O   1 
ATOM   3464 C CB  . ILE A 1 489 ? 101.623 101.906 127.184 1.00 134.82 ?  489 ILE A CB  1 
ATOM   3465 C CG1 . ILE A 1 489 ? 102.938 101.286 126.710 1.00 139.14 ?  489 ILE A CG1 1 
ATOM   3466 C CG2 . ILE A 1 489 ? 100.609 101.922 126.062 1.00 136.58 ?  489 ILE A CG2 1 
ATOM   3467 C CD1 . ILE A 1 489 ? 102.766 99.980  125.970 1.00 134.59 ?  489 ILE A CD1 1 
ATOM   3468 N N   . TYR A 1 490 ? 101.973 104.863 125.852 1.00 129.08 ?  490 TYR A N   1 
ATOM   3469 C CA  . TYR A 1 490 ? 102.607 105.771 124.903 1.00 133.31 ?  490 TYR A CA  1 
ATOM   3470 C C   . TYR A 1 490 ? 103.342 106.907 125.585 1.00 136.84 ?  490 TYR A C   1 
ATOM   3471 O O   . TYR A 1 490 ? 104.190 107.542 124.951 1.00 142.60 ?  490 TYR A O   1 
ATOM   3472 C CB  . TYR A 1 490 ? 101.556 106.365 123.963 1.00 133.48 ?  490 TYR A CB  1 
ATOM   3473 C CG  . TYR A 1 490 ? 101.138 105.465 122.830 1.00 137.06 ?  490 TYR A CG  1 
ATOM   3474 C CD1 . TYR A 1 490 ? 101.894 104.363 122.486 1.00 138.35 ?  490 TYR A CD1 1 
ATOM   3475 C CD2 . TYR A 1 490 ? 99.974  105.710 122.117 1.00 136.45 ?  490 TYR A CD2 1 
ATOM   3476 C CE1 . TYR A 1 490 ? 101.519 103.545 121.456 1.00 138.47 ?  490 TYR A CE1 1 
ATOM   3477 C CE2 . TYR A 1 490 ? 99.585  104.888 121.089 1.00 131.67 ?  490 TYR A CE2 1 
ATOM   3478 C CZ  . TYR A 1 490 ? 100.362 103.804 120.763 1.00 134.12 ?  490 TYR A CZ  1 
ATOM   3479 O OH  . TYR A 1 490 ? 99.989  102.974 119.736 1.00 142.79 ?  490 TYR A OH  1 
ATOM   3480 N N   . GLY A 1 491 ? 102.991 107.216 126.827 1.00 146.99 ?  491 GLY A N   1 
ATOM   3481 C CA  . GLY A 1 491 ? 103.730 108.206 127.585 1.00 150.81 ?  491 GLY A CA  1 
ATOM   3482 C C   . GLY A 1 491 ? 104.671 107.626 128.617 1.00 155.29 ?  491 GLY A C   1 
ATOM   3483 O O   . GLY A 1 491 ? 105.673 108.255 128.968 1.00 159.85 ?  491 GLY A O   1 
ATOM   3484 N N   . ALA A 1 492 ? 104.354 106.433 129.124 1.00 145.65 ?  492 ALA A N   1 
ATOM   3485 C CA  . ALA A 1 492 ? 105.243 105.784 130.079 1.00 147.11 ?  492 ALA A CA  1 
ATOM   3486 C C   . ALA A 1 492 ? 106.566 105.413 129.427 1.00 147.99 ?  492 ALA A C   1 
ATOM   3487 O O   . ALA A 1 492 ? 107.625 105.511 130.058 1.00 150.03 ?  492 ALA A O   1 
ATOM   3488 C CB  . ALA A 1 492 ? 104.568 104.549 130.675 1.00 145.37 ?  492 ALA A CB  1 
ATOM   3489 N N   . VAL A 1 493 ? 106.527 104.973 128.167 1.00 131.43 ?  493 VAL A N   1 
ATOM   3490 C CA  . VAL A 1 493 ? 107.768 104.613 127.475 1.00 134.48 ?  493 VAL A CA  1 
ATOM   3491 C C   . VAL A 1 493 ? 108.703 105.809 127.292 1.00 134.27 ?  493 VAL A C   1 
ATOM   3492 O O   . VAL A 1 493 ? 109.898 105.683 127.610 1.00 136.94 ?  493 VAL A O   1 
ATOM   3493 C CB  . VAL A 1 493 ? 107.446 103.893 126.154 1.00 133.09 ?  493 VAL A CB  1 
ATOM   3494 C CG1 . VAL A 1 493 ? 108.719 103.548 125.417 1.00 134.12 ?  493 VAL A CG1 1 
ATOM   3495 C CG2 . VAL A 1 493 ? 106.638 102.640 126.425 1.00 131.35 ?  493 VAL A CG2 1 
ATOM   3496 N N   . PRO A 1 494 ? 108.252 106.969 126.793 1.00 133.87 ?  494 PRO A N   1 
ATOM   3497 C CA  . PRO A 1 494 ? 109.181 108.105 126.659 1.00 139.67 ?  494 PRO A CA  1 
ATOM   3498 C C   . PRO A 1 494 ? 109.776 108.579 127.972 1.00 144.30 ?  494 PRO A C   1 
ATOM   3499 O O   . PRO A 1 494 ? 110.922 109.041 127.978 1.00 146.64 ?  494 PRO A O   1 
ATOM   3500 C CB  . PRO A 1 494 ? 108.313 109.193 126.016 1.00 136.03 ?  494 PRO A CB  1 
ATOM   3501 C CG  . PRO A 1 494 ? 107.280 108.451 125.290 1.00 138.63 ?  494 PRO A CG  1 
ATOM   3502 C CD  . PRO A 1 494 ? 106.964 107.266 126.149 1.00 136.53 ?  494 PRO A CD  1 
ATOM   3503 N N   . VAL A 1 495 ? 109.039 108.502 129.082 1.00 140.23 ?  495 VAL A N   1 
ATOM   3504 C CA  . VAL A 1 495 ? 109.612 108.891 130.368 1.00 141.79 ?  495 VAL A CA  1 
ATOM   3505 C C   . VAL A 1 495 ? 110.750 107.950 130.743 1.00 145.86 ?  495 VAL A C   1 
ATOM   3506 O O   . VAL A 1 495 ? 111.800 108.380 131.239 1.00 148.31 ?  495 VAL A O   1 
ATOM   3507 C CB  . VAL A 1 495 ? 108.520 108.933 131.452 1.00 141.49 ?  495 VAL A CB  1 
ATOM   3508 C CG1 . VAL A 1 495 ? 109.127 109.252 132.805 1.00 144.85 ?  495 VAL A CG1 1 
ATOM   3509 C CG2 . VAL A 1 495 ? 107.462 109.961 131.092 1.00 141.75 ?  495 VAL A CG2 1 
ATOM   3510 N N   . ALA A 1 496 ? 110.562 106.650 130.505 1.00 130.39 ?  496 ALA A N   1 
ATOM   3511 C CA  . ALA A 1 496 ? 111.636 105.693 130.741 1.00 129.40 ?  496 ALA A CA  1 
ATOM   3512 C C   . ALA A 1 496 ? 112.836 105.982 129.850 1.00 135.43 ?  496 ALA A C   1 
ATOM   3513 O O   . ALA A 1 496 ? 113.985 105.866 130.292 1.00 141.89 ?  496 ALA A O   1 
ATOM   3514 C CB  . ALA A 1 496 ? 111.130 104.270 130.517 1.00 130.50 ?  496 ALA A CB  1 
ATOM   3515 N N   . ALA A 1 497 ? 112.595 106.360 128.593 1.00 145.75 ?  497 ALA A N   1 
ATOM   3516 C CA  . ALA A 1 497 ? 113.706 106.714 127.712 1.00 145.70 ?  497 ALA A CA  1 
ATOM   3517 C C   . ALA A 1 497 ? 114.437 107.955 128.209 1.00 140.91 ?  497 ALA A C   1 
ATOM   3518 O O   . ALA A 1 497 ? 115.670 108.029 128.142 1.00 148.07 ?  497 ALA A O   1 
ATOM   3519 C CB  . ALA A 1 497 ? 113.202 106.932 126.290 1.00 146.16 ?  497 ALA A CB  1 
ATOM   3520 N N   . SER A 1 498 ? 113.692 108.947 128.695 1.00 136.04 ?  498 SER A N   1 
ATOM   3521 C CA  . SER A 1 498 ? 114.319 110.147 129.236 1.00 142.53 ?  498 SER A CA  1 
ATOM   3522 C C   . SER A 1 498 ? 115.177 109.813 130.448 1.00 144.73 ?  498 SER A C   1 
ATOM   3523 O O   . SER A 1 498 ? 116.274 110.360 130.613 1.00 147.56 ?  498 SER A O   1 
ATOM   3524 C CB  . SER A 1 498 ? 113.253 111.178 129.601 1.00 148.76 ?  498 SER A CB  1 
ATOM   3525 O OG  . SER A 1 498 ? 112.697 110.905 130.875 1.00 150.11 ?  498 SER A OG  1 
ATOM   3526 N N   . ALA A 1 499 ? 114.690 108.919 131.310 1.00 153.16 ?  499 ALA A N   1 
ATOM   3527 C CA  . ALA A 1 499 ? 115.505 108.462 132.432 1.00 157.20 ?  499 ALA A CA  1 
ATOM   3528 C C   . ALA A 1 499 ? 116.747 107.716 131.958 1.00 156.86 ?  499 ALA A C   1 
ATOM   3529 O O   . ALA A 1 499 ? 117.824 107.871 132.546 1.00 153.70 ?  499 ALA A O   1 
ATOM   3530 C CB  . ALA A 1 499 ? 114.674 107.579 133.361 1.00 158.47 ?  499 ALA A CB  1 
ATOM   3531 N N   . VAL A 1 500 ? 116.616 106.902 130.907 1.00 151.92 ?  500 VAL A N   1 
ATOM   3532 C CA  . VAL A 1 500 ? 117.758 106.171 130.361 1.00 150.88 ?  500 VAL A CA  1 
ATOM   3533 C C   . VAL A 1 500 ? 118.795 107.130 129.792 1.00 151.14 ?  500 VAL A C   1 
ATOM   3534 O O   . VAL A 1 500 ? 120.003 106.872 129.868 1.00 152.63 ?  500 VAL A O   1 
ATOM   3535 C CB  . VAL A 1 500 ? 117.271 105.157 129.304 1.00 149.05 ?  500 VAL A CB  1 
ATOM   3536 C CG1 . VAL A 1 500 ? 118.342 104.893 128.258 1.00 145.32 ?  500 VAL A CG1 1 
ATOM   3537 C CG2 . VAL A 1 500 ? 116.850 103.861 129.974 1.00 150.53 ?  500 VAL A CG2 1 
ATOM   3538 N N   . THR A 1 501 ? 118.345 108.261 129.245 1.00 151.44 ?  501 THR A N   1 
ATOM   3539 C CA  . THR A 1 501 ? 119.242 109.223 128.609 1.00 149.33 ?  501 THR A CA  1 
ATOM   3540 C C   . THR A 1 501 ? 120.349 109.696 129.549 1.00 153.28 ?  501 THR A C   1 
ATOM   3541 O O   . THR A 1 501 ? 121.429 110.068 129.076 1.00 158.98 ?  501 THR A O   1 
ATOM   3542 C CB  . THR A 1 501 ? 118.413 110.404 128.081 1.00 152.13 ?  501 THR A CB  1 
ATOM   3543 O OG1 . THR A 1 501 ? 117.841 110.055 126.815 1.00 154.09 ?  501 THR A OG1 1 
ATOM   3544 C CG2 . THR A 1 501 ? 119.244 111.667 127.912 1.00 156.34 ?  501 THR A CG2 1 
ATOM   3545 N N   . VAL A 1 502 ? 120.127 109.627 130.865 1.00 156.50 ?  502 VAL A N   1 
ATOM   3546 C CA  . VAL A 1 502 ? 121.132 110.062 131.834 1.00 161.38 ?  502 VAL A CA  1 
ATOM   3547 C C   . VAL A 1 502 ? 122.457 109.346 131.601 1.00 161.00 ?  502 VAL A C   1 
ATOM   3548 O O   . VAL A 1 502 ? 123.531 109.957 131.673 1.00 159.44 ?  502 VAL A O   1 
ATOM   3549 C CB  . VAL A 1 502 ? 120.614 109.832 133.267 1.00 162.93 ?  502 VAL A CB  1 
ATOM   3550 C CG1 . VAL A 1 502 ? 121.766 109.599 134.231 1.00 159.62 ?  502 VAL A CG1 1 
ATOM   3551 C CG2 . VAL A 1 502 ? 119.772 111.004 133.722 1.00 163.94 ?  502 VAL A CG2 1 
ATOM   3552 N N   . LEU A 1 503 ? 122.404 108.045 131.306 1.00 164.29 ?  503 LEU A N   1 
ATOM   3553 C CA  . LEU A 1 503 ? 123.629 107.256 131.199 1.00 168.19 ?  503 LEU A CA  1 
ATOM   3554 C C   . LEU A 1 503 ? 124.499 107.710 130.031 1.00 167.93 ?  503 LEU A C   1 
ATOM   3555 O O   . LEU A 1 503 ? 125.720 107.520 130.052 1.00 167.81 ?  503 LEU A O   1 
ATOM   3556 C CB  . LEU A 1 503 ? 123.282 105.775 131.067 1.00 162.95 ?  503 LEU A CB  1 
ATOM   3557 C CG  . LEU A 1 503 ? 122.457 105.193 132.216 1.00 161.21 ?  503 LEU A CG  1 
ATOM   3558 C CD1 . LEU A 1 503 ? 121.759 103.915 131.784 1.00 162.40 ?  503 LEU A CD1 1 
ATOM   3559 C CD2 . LEU A 1 503 ? 123.331 104.947 133.432 1.00 163.98 ?  503 LEU A CD2 1 
ATOM   3560 N N   . LEU A 1 504 ? 123.895 108.306 129.005 1.00 167.56 ?  504 LEU A N   1 
ATOM   3561 C CA  . LEU A 1 504 ? 124.657 108.729 127.842 1.00 165.28 ?  504 LEU A CA  1 
ATOM   3562 C C   . LEU A 1 504 ? 125.579 109.897 128.191 1.00 168.36 ?  504 LEU A C   1 
ATOM   3563 O O   . LEU A 1 504 ? 125.251 110.725 129.044 1.00 167.66 ?  504 LEU A O   1 
ATOM   3564 C CB  . LEU A 1 504 ? 123.720 109.125 126.706 1.00 165.70 ?  504 LEU A CB  1 
ATOM   3565 C CG  . LEU A 1 504 ? 123.006 107.939 126.063 1.00 169.09 ?  504 LEU A CG  1 
ATOM   3566 C CD1 . LEU A 1 504 ? 122.159 108.376 124.887 1.00 169.19 ?  504 LEU A CD1 1 
ATOM   3567 C CD2 . LEU A 1 504 ? 124.028 106.913 125.628 1.00 164.45 ?  504 LEU A CD2 1 
ATOM   3568 N N   . PRO A 1 505 ? 126.742 109.984 127.544 1.00 180.45 ?  505 PRO A N   1 
ATOM   3569 C CA  . PRO A 1 505 ? 127.677 111.076 127.835 1.00 179.68 ?  505 PRO A CA  1 
ATOM   3570 C C   . PRO A 1 505 ? 127.424 112.307 126.978 1.00 180.06 ?  505 PRO A C   1 
ATOM   3571 O O   . PRO A 1 505 ? 127.000 112.222 125.824 1.00 181.70 ?  505 PRO A O   1 
ATOM   3572 C CB  . PRO A 1 505 ? 129.038 110.451 127.504 1.00 176.06 ?  505 PRO A CB  1 
ATOM   3573 C CG  . PRO A 1 505 ? 128.738 109.437 126.437 1.00 177.10 ?  505 PRO A CG  1 
ATOM   3574 C CD  . PRO A 1 505 ? 127.277 109.057 126.532 1.00 176.84 ?  505 PRO A CD  1 
ATOM   3575 N N   . GLU A 1 506 ? 127.692 113.471 127.565 1.00 194.09 ?  506 GLU A N   1 
ATOM   3576 C CA  . GLU A 1 506 ? 127.541 114.726 126.841 1.00 194.51 ?  506 GLU A CA  1 
ATOM   3577 C C   . GLU A 1 506 ? 128.552 114.799 125.704 1.00 195.64 ?  506 GLU A C   1 
ATOM   3578 O O   . GLU A 1 506 ? 129.719 114.433 125.870 1.00 198.22 ?  506 GLU A O   1 
ATOM   3579 C CB  . GLU A 1 506 ? 127.722 115.908 127.794 1.00 196.03 ?  506 GLU A CB  1 
ATOM   3580 C CG  . GLU A 1 506 ? 127.672 117.270 127.125 1.00 193.96 ?  506 GLU A CG  1 
ATOM   3581 C CD  . GLU A 1 506 ? 127.656 118.405 128.129 1.00 195.94 ?  506 GLU A CD  1 
ATOM   3582 O OE1 . GLU A 1 506 ? 126.723 118.454 128.958 1.00 194.73 ?  506 GLU A OE1 1 
ATOM   3583 O OE2 . GLU A 1 506 ? 128.577 119.248 128.090 1.00 195.67 -1 506 GLU A OE2 1 
ATOM   3584 N N   . THR A 1 507 ? 128.101 115.269 124.542 1.00 189.77 ?  507 THR A N   1 
ATOM   3585 C CA  . THR A 1 507 ? 128.938 115.319 123.352 1.00 190.98 ?  507 THR A CA  1 
ATOM   3586 C C   . THR A 1 507 ? 129.187 116.732 122.845 1.00 190.74 ?  507 THR A C   1 
ATOM   3587 O O   . THR A 1 507 ? 129.882 116.896 121.838 1.00 188.83 ?  507 THR A O   1 
ATOM   3588 C CB  . THR A 1 507 ? 128.312 114.490 122.224 1.00 187.90 ?  507 THR A CB  1 
ATOM   3589 O OG1 . THR A 1 507 ? 127.400 115.307 121.480 1.00 188.59 ?  507 THR A OG1 1 
ATOM   3590 C CG2 . THR A 1 507 ? 127.558 113.309 122.795 1.00 188.05 ?  507 THR A CG2 1 
ATOM   3591 N N   . LEU A 1 508 ? 128.652 117.753 123.507 1.00 194.34 ?  508 LEU A N   1 
ATOM   3592 C CA  . LEU A 1 508 ? 128.800 119.117 123.013 1.00 193.99 ?  508 LEU A CA  1 
ATOM   3593 C C   . LEU A 1 508 ? 130.233 119.591 123.222 1.00 195.79 ?  508 LEU A C   1 
ATOM   3594 O O   . LEU A 1 508 ? 130.776 119.489 124.328 1.00 195.42 ?  508 LEU A O   1 
ATOM   3595 C CB  . LEU A 1 508 ? 127.817 120.049 123.714 1.00 192.90 ?  508 LEU A CB  1 
ATOM   3596 C CG  . LEU A 1 508 ? 127.992 121.530 123.380 1.00 193.82 ?  508 LEU A CG  1 
ATOM   3597 C CD1 . LEU A 1 508 ? 127.872 121.739 121.883 1.00 191.17 ?  508 LEU A CD1 1 
ATOM   3598 C CD2 . LEU A 1 508 ? 126.973 122.379 124.118 1.00 194.70 ?  508 LEU A CD2 1 
ATOM   3599 N N   . GLY A 1 509 ? 130.846 120.108 122.158 1.00 199.10 ?  509 GLY A N   1 
ATOM   3600 C CA  . GLY A 1 509 ? 132.208 120.588 122.219 1.00 199.31 ?  509 GLY A CA  1 
ATOM   3601 C C   . GLY A 1 509 ? 133.272 119.515 122.186 1.00 199.17 ?  509 GLY A C   1 
ATOM   3602 O O   . GLY A 1 509 ? 134.454 119.834 122.367 1.00 200.25 ?  509 GLY A O   1 
ATOM   3603 N N   . GLN A 1 510 ? 132.899 118.258 121.969 1.00 199.96 ?  510 GLN A N   1 
ATOM   3604 C CA  . GLN A 1 510 ? 133.844 117.153 121.948 1.00 201.76 ?  510 GLN A CA  1 
ATOM   3605 C C   . GLN A 1 510 ? 133.986 116.619 120.526 1.00 201.51 ?  510 GLN A C   1 
ATOM   3606 O O   . GLN A 1 510 ? 132.982 116.463 119.822 1.00 199.51 ?  510 GLN A O   1 
ATOM   3607 C CB  . GLN A 1 510 ? 133.365 116.025 122.865 1.00 200.08 ?  510 GLN A CB  1 
ATOM   3608 C CG  . GLN A 1 510 ? 133.988 115.969 124.269 1.00 199.40 ?  510 GLN A CG  1 
ATOM   3609 C CD  . GLN A 1 510 ? 135.484 115.707 124.291 1.00 202.88 ?  510 GLN A CD  1 
ATOM   3610 O OE1 . GLN A 1 510 ? 136.276 116.484 123.760 1.00 203.21 ?  510 GLN A OE1 1 
ATOM   3611 N NE2 . GLN A 1 510 ? 135.877 114.603 124.914 1.00 202.87 ?  510 GLN A NE2 1 
ATOM   3612 N N   . PRO A 1 511 ? 135.223 116.338 120.083 1.00 196.09 ?  511 PRO A N   1 
ATOM   3613 C CA  . PRO A 1 511 ? 135.316 115.770 118.737 1.00 194.55 ?  511 PRO A CA  1 
ATOM   3614 C C   . PRO A 1 511 ? 134.678 114.399 118.641 1.00 193.91 ?  511 PRO A C   1 
ATOM   3615 O O   . PRO A 1 511 ? 134.517 113.728 119.657 1.00 195.10 ?  511 PRO A O   1 
ATOM   3616 C CB  . PRO A 1 511 ? 136.825 115.638 118.522 1.00 194.36 ?  511 PRO A CB  1 
ATOM   3617 C CG  . PRO A 1 511 ? 137.400 115.554 119.893 1.00 192.40 ?  511 PRO A CG  1 
ATOM   3618 C CD  . PRO A 1 511 ? 136.549 116.473 120.713 1.00 193.86 ?  511 PRO A CD  1 
ATOM   3619 N N   . LEU A 1 512 ? 134.321 113.980 117.433 1.00 187.75 ?  512 LEU A N   1 
ATOM   3620 C CA  . LEU A 1 512 ? 133.764 112.648 117.253 1.00 188.33 ?  512 LEU A CA  1 
ATOM   3621 C C   . LEU A 1 512 ? 134.826 111.616 117.587 1.00 190.00 ?  512 LEU A C   1 
ATOM   3622 O O   . LEU A 1 512 ? 136.010 111.839 117.342 1.00 191.48 ?  512 LEU A O   1 
ATOM   3623 C CB  . LEU A 1 512 ? 133.250 112.462 115.824 1.00 187.98 ?  512 LEU A CB  1 
ATOM   3624 C CG  . LEU A 1 512 ? 134.188 112.754 114.651 1.00 186.82 ?  512 LEU A CG  1 
ATOM   3625 C CD1 . LEU A 1 512 ? 135.170 111.613 114.429 1.00 185.91 ?  512 LEU A CD1 1 
ATOM   3626 C CD2 . LEU A 1 512 ? 133.370 112.989 113.391 1.00 186.63 ?  512 LEU A CD2 1 
ATOM   3627 N N   . PRO A 1 513 ? 134.413 110.484 118.165 1.00 197.82 ?  513 PRO A N   1 
ATOM   3628 C CA  . PRO A 1 513 ? 135.410 109.498 118.577 1.00 200.07 ?  513 PRO A CA  1 
ATOM   3629 C C   . PRO A 1 513 ? 135.871 108.661 117.398 1.00 201.18 ?  513 PRO A C   1 
ATOM   3630 O O   . PRO A 1 513 ? 135.156 108.565 116.402 1.00 199.40 ?  513 PRO A O   1 
ATOM   3631 C CB  . PRO A 1 513 ? 134.637 108.632 119.562 1.00 201.28 ?  513 PRO A CB  1 
ATOM   3632 C CG  . PRO A 1 513 ? 133.231 108.682 119.065 1.00 198.85 ?  513 PRO A CG  1 
ATOM   3633 C CD  . PRO A 1 513 ? 133.039 110.050 118.468 1.00 196.10 ?  513 PRO A CD  1 
ATOM   3634 N N   . ASP A 1 514 ? 137.051 108.060 117.505 1.00 205.89 ?  514 ASP A N   1 
ATOM   3635 C CA  . ASP A 1 514 ? 137.549 107.208 116.434 1.00 205.34 ?  514 ASP A CA  1 
ATOM   3636 C C   . ASP A 1 514 ? 137.805 105.771 116.858 1.00 204.71 ?  514 ASP A C   1 
ATOM   3637 O O   . ASP A 1 514 ? 137.959 104.907 115.993 1.00 202.77 ?  514 ASP A O   1 
ATOM   3638 C CB  . ASP A 1 514 ? 138.845 107.787 115.854 1.00 204.80 ?  514 ASP A CB  1 
ATOM   3639 C CG  . ASP A 1 514 ? 138.633 109.125 115.174 1.00 204.56 ?  514 ASP A CG  1 
ATOM   3640 O OD1 . ASP A 1 514 ? 139.294 110.107 115.572 1.00 202.14 ?  514 ASP A OD1 1 
ATOM   3641 O OD2 . ASP A 1 514 ? 137.807 109.194 114.240 1.00 206.12 -1 514 ASP A OD2 1 
ATOM   3642 N N   . THR A 1 515 ? 137.857 105.492 118.159 1.00 216.54 ?  515 THR A N   1 
ATOM   3643 C CA  . THR A 1 515 ? 138.161 104.161 118.659 1.00 217.43 ?  515 THR A CA  1 
ATOM   3644 C C   . THR A 1 515 ? 137.439 103.920 119.978 1.00 216.14 ?  515 THR A C   1 
ATOM   3645 O O   . THR A 1 515 ? 136.889 104.837 120.594 1.00 213.92 ?  515 THR A O   1 
ATOM   3646 C CB  . THR A 1 515 ? 139.672 103.963 118.842 1.00 217.20 ?  515 THR A CB  1 
ATOM   3647 O OG1 . THR A 1 515 ? 139.959 102.566 118.992 1.00 218.00 ?  515 THR A OG1 1 
ATOM   3648 C CG2 . THR A 1 515 ? 140.164 104.717 120.067 1.00 215.34 ?  515 THR A CG2 1 
ATOM   3649 N N   . VAL A 1 516 ? 137.450 102.655 120.405 1.00 230.49 ?  516 VAL A N   1 
ATOM   3650 C CA  . VAL A 1 516 ? 136.821 102.280 121.669 1.00 231.47 ?  516 VAL A CA  1 
ATOM   3651 C C   . VAL A 1 516 ? 137.545 102.934 122.839 1.00 231.34 ?  516 VAL A C   1 
ATOM   3652 O O   . VAL A 1 516 ? 136.935 103.255 123.868 1.00 231.86 ?  516 VAL A O   1 
ATOM   3653 C CB  . VAL A 1 516 ? 136.784 100.747 121.808 1.00 230.94 ?  516 VAL A CB  1 
ATOM   3654 N N   . GLN A 1 517 ? 138.859 103.133 122.706 1.00 235.56 ?  517 GLN A N   1 
ATOM   3655 C CA  . GLN A 1 517 ? 139.629 103.747 123.782 1.00 236.42 ?  517 GLN A CA  1 
ATOM   3656 C C   . GLN A 1 517 ? 139.174 105.178 124.040 1.00 236.65 ?  517 GLN A C   1 
ATOM   3657 O O   . GLN A 1 517 ? 139.146 105.631 125.190 1.00 236.83 ?  517 GLN A O   1 
ATOM   3658 C CB  . GLN A 1 517 ? 141.121 103.706 123.450 1.00 235.27 ?  517 GLN A CB  1 
ATOM   3659 C CG  . GLN A 1 517 ? 141.707 102.306 123.426 1.00 236.13 ?  517 GLN A CG  1 
ATOM   3660 C CD  . GLN A 1 517 ? 143.169 102.296 123.023 1.00 236.44 ?  517 GLN A CD  1 
ATOM   3661 O OE1 . GLN A 1 517 ? 143.642 103.204 122.337 1.00 235.73 ?  517 GLN A OE1 1 
ATOM   3662 N NE2 . GLN A 1 517 ? 143.893 101.266 123.443 1.00 236.37 ?  517 GLN A NE2 1 
ATOM   3663 N N   . ASP A 1 518 ? 138.816 105.907 122.980 1.00 226.62 ?  518 ASP A N   1 
ATOM   3664 C CA  . ASP A 1 518 ? 138.270 107.248 123.160 1.00 226.74 ?  518 ASP A CA  1 
ATOM   3665 C C   . ASP A 1 518 ? 136.965 107.206 123.943 1.00 226.26 ?  518 ASP A C   1 
ATOM   3666 O O   . ASP A 1 518 ? 136.720 108.057 124.806 1.00 225.53 ?  518 ASP A O   1 
ATOM   3667 C CB  . ASP A 1 518 ? 138.058 107.916 121.802 1.00 226.56 ?  518 ASP A CB  1 
ATOM   3668 C CG  . ASP A 1 518 ? 138.073 109.430 121.888 1.00 226.42 ?  518 ASP A CG  1 
ATOM   3669 O OD1 . ASP A 1 518 ? 138.116 109.963 123.016 1.00 227.08 ?  518 ASP A OD1 1 
ATOM   3670 O OD2 . ASP A 1 518 ? 138.039 110.087 120.826 1.00 224.90 -1 518 ASP A OD2 1 
ATOM   3671 N N   . LEU A 1 519 ? 136.113 106.222 123.649 1.00 225.82 ?  519 LEU A N   1 
ATOM   3672 C CA  . LEU A 1 519 ? 134.876 106.056 124.403 1.00 226.61 ?  519 LEU A CA  1 
ATOM   3673 C C   . LEU A 1 519 ? 135.161 105.768 125.871 1.00 227.72 ?  519 LEU A C   1 
ATOM   3674 O O   . LEU A 1 519 ? 134.510 106.329 126.761 1.00 227.06 ?  519 LEU A O   1 
ATOM   3675 C CB  . LEU A 1 519 ? 134.049 104.929 123.792 1.00 226.55 ?  519 LEU A CB  1 
ATOM   3676 C CG  . LEU A 1 519 ? 133.427 105.198 122.425 1.00 224.72 ?  519 LEU A CG  1 
ATOM   3677 C CD1 . LEU A 1 519 ? 132.319 104.202 122.173 1.00 225.47 ?  519 LEU A CD1 1 
ATOM   3678 C CD2 . LEU A 1 519 ? 132.901 106.621 122.343 1.00 222.90 ?  519 LEU A CD2 1 
ATOM   3679 N N   . GLU A 1 520 ? 136.130 104.892 126.141 1.00 237.79 ?  520 GLU A N   1 
ATOM   3680 C CA  . GLU A 1 520 ? 136.458 104.550 127.521 1.00 236.91 ?  520 GLU A CA  1 
ATOM   3681 C C   . GLU A 1 520 ? 137.049 105.745 128.259 1.00 236.89 ?  520 GLU A C   1 
ATOM   3682 O O   . GLU A 1 520 ? 136.857 105.893 129.472 1.00 238.15 ?  520 GLU A O   1 
ATOM   3683 C CB  . GLU A 1 520 ? 137.423 103.366 127.550 1.00 236.43 ?  520 GLU A CB  1 
ATOM   3684 N N   . SER A 1 521 ? 137.775 106.607 127.543 1.00 229.71 ?  521 SER A N   1 
ATOM   3685 C CA  . SER A 1 521 ? 138.330 107.805 128.164 1.00 230.16 ?  521 SER A CA  1 
ATOM   3686 C C   . SER A 1 521 ? 137.234 108.758 128.622 1.00 230.46 ?  521 SER A C   1 
ATOM   3687 O O   . SER A 1 521 ? 137.400 109.456 129.629 1.00 230.41 ?  521 SER A O   1 
ATOM   3688 C CB  . SER A 1 521 ? 139.275 108.510 127.192 1.00 228.83 ?  521 SER A CB  1 
ATOM   3689 N N   . ARG A 1 522 ? 136.118 108.806 127.901 1.00 224.88 ?  522 ARG A N   1 
ATOM   3690 C CA  . ARG A 1 522 ? 134.989 109.641 128.292 1.00 225.69 ?  522 ARG A CA  1 
ATOM   3691 C C   . ARG A 1 522 ? 134.350 109.124 129.578 1.00 226.24 ?  522 ARG A C   1 
ATOM   3692 O O   . ARG A 1 522 ? 133.811 109.896 130.371 1.00 225.66 ?  522 ARG A O   1 
ATOM   3693 C CB  . ARG A 1 522 ? 133.947 109.694 127.174 1.00 226.31 ?  522 ARG A CB  1 
HETATM 3694 C C10 A ZWD B 2 .   ? 110.922 105.682 110.003 0.50 150.66 ?  601 ZWD A C10 1 
HETATM 3695 C C10 B ZWD B 2 .   ? 111.087 113.981 111.522 0.50 150.66 ?  601 ZWD A C10 1 
HETATM 3696 C C01 A ZWD B 2 .   ? 112.108 109.765 109.346 0.50 151.73 ?  601 ZWD A C01 1 
HETATM 3697 C C01 B ZWD B 2 .   ? 110.142 109.693 111.462 0.50 151.73 ?  601 ZWD A C01 1 
HETATM 3698 C C02 A ZWD B 2 .   ? 112.620 111.059 109.320 0.50 151.88 ?  601 ZWD A C02 1 
HETATM 3699 C C02 B ZWD B 2 .   ? 110.215 108.318 111.627 0.50 151.88 ?  601 ZWD A C02 1 
HETATM 3700 C C03 A ZWD B 2 .   ? 111.952 112.072 109.993 0.50 153.75 ?  601 ZWD A C03 1 
HETATM 3701 C C03 B ZWD B 2 .   ? 111.115 107.591 110.870 0.50 153.75 ?  601 ZWD A C03 1 
HETATM 3702 C C04 A ZWD B 2 .   ? 110.783 111.812 110.690 0.50 147.55 ?  601 ZWD A C04 1 
HETATM 3703 C C04 B ZWD B 2 .   ? 111.938 108.220 109.949 0.50 147.55 ?  601 ZWD A C04 1 
HETATM 3704 C C05 A ZWD B 2 .   ? 110.268 110.529 110.721 0.50 144.52 ?  601 ZWD A C05 1 
HETATM 3705 C C05 B ZWD B 2 .   ? 111.870 109.591 109.774 0.50 144.52 ?  601 ZWD A C05 1 
HETATM 3706 C C06 A ZWD B 2 .   ? 110.927 109.490 110.048 0.50 150.41 ?  601 ZWD A C06 1 
HETATM 3707 C C06 B ZWD B 2 .   ? 110.970 110.333 110.541 0.50 150.41 ?  601 ZWD A C06 1 
HETATM 3708 C C07 A ZWD B 2 .   ? 110.374 108.096 110.078 0.50 153.08 ?  601 ZWD A C07 1 
HETATM 3709 C C07 B ZWD B 2 .   ? 110.848 111.808 110.394 0.50 153.08 ?  601 ZWD A C07 1 
HETATM 3710 C C11 A ZWD B 2 .   ? 111.564 104.957 108.807 0.50 156.27 ?  601 ZWD A C11 1 
HETATM 3711 C C11 B ZWD B 2 .   ? 109.633 114.288 111.887 0.50 156.27 ?  601 ZWD A C11 1 
HETATM 3712 N N09 A ZWD B 2 .   ? 111.267 107.106 109.988 0.50 153.61 ?  601 ZWD A N09 1 
HETATM 3713 N N09 B ZWD B 2 .   ? 111.173 112.531 111.456 0.50 153.61 ?  601 ZWD A N09 1 
HETATM 3714 N N14 A ZWD B 2 .   ? 112.454 113.360 109.972 0.50 152.05 ?  601 ZWD A N14 1 
HETATM 3715 N N14 B ZWD B 2 .   ? 111.194 106.223 111.038 0.50 152.05 ?  601 ZWD A N14 1 
HETATM 3716 O O08 A ZWD B 2 .   ? 109.169 107.885 110.183 0.50 153.86 ?  601 ZWD A O08 1 
HETATM 3717 O O08 B ZWD B 2 .   ? 110.465 112.308 109.358 0.50 153.86 ?  601 ZWD A O08 1 
HETATM 3718 O O12 A ZWD B 2 .   ? 112.072 103.860 108.833 0.50 159.82 ?  601 ZWD A O12 1 
HETATM 3719 O O12 B ZWD B 2 .   ? 108.738 113.480 111.946 0.50 159.82 ?  601 ZWD A O12 1 
HETATM 3720 O O13 A ZWD B 2 .   ? 111.484 105.712 107.690 0.50 156.62 ?  601 ZWD A O13 1 
HETATM 3721 O O13 B ZWD B 2 .   ? 109.476 115.598 112.153 0.50 156.62 ?  601 ZWD A O13 1 
# 
