data_9MAU
# 
_entry.id   9MAU 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9MAU         pdb_00009mau 10.2210/pdb9mau/pdb 
WWPDB D_1300057550 ?            ?                   
EMDB  EMD-63758    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-06-18 ? 
2 'EM metadata'     1 0 2025-06-18 ? 
3 FSC               1 0 2025-06-18 ? 
4 'Half map'        1 0 2025-06-18 1 
5 'Half map'        1 0 2025-06-18 2 
6 Image             1 0 2025-06-18 ? 
7 'Primary map'     1 0 2025-06-18 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 FSC               repository 'Initial release' ? ? 
4 4 'Half map'        repository 'Initial release' ? ? 
5 5 'Half map'        repository 'Initial release' ? ? 
6 6 Image             repository 'Initial release' ? ? 
7 7 'Primary map'     repository 'Initial release' ? ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9MAU 
_pdbx_database_status.recvd_initial_deposition_date   2025-03-14 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM structure of human OAT1 in the apo state' 
_pdbx_database_related.db_id          EMD-63758 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              w_zhang21@m.fudan.edu.cn 
_pdbx_contact_author.name_first         Yanqing 
_pdbx_contact_author.name_last          Zhang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-7654-1645 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zhang, W.' 1 ? 
'Zhang, Y.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Cryo-EM structure of human SLC22A6 in the apo state' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zhang, W.' 1 ? 
primary 'Zhang, Y.' 2 ? 
# 
_entity.id                         1 
_entity.type                       polymer 
_entity.src_method                 man 
_entity.pdbx_description           'Isoform 2 of Solute carrier family 22 member 6' 
_entity.formula_weight             63119.156 
_entity.pdbx_number_of_molecules   1 
_entity.pdbx_ec                    ? 
_entity.pdbx_mutation              ? 
_entity.pdbx_fragment              ? 
_entity.details                    ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Organic anion transporter 1,hOAT1,PAH transporter,hPAHT,Renal organic anion transporter 1,hROAT1' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEVWLPRDRQGQPESCLR
FTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLG
RRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV
AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMG
KGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMA
ALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAE
LYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRKGKQTRQQQEHQKYMVPLQASAQEKNGLHHHHHHHHHH
GSVEDYKDDDDK
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEVWLPRDRQGQPESCLR
FTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLG
RRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV
AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMG
KGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMA
ALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAE
LYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRKGKQTRQQQEHQKYMVPLQASAQEKNGLHHHHHHHHHH
GSVEDYKDDDDK
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   PHE n 
1 4   ASN n 
1 5   ASP n 
1 6   LEU n 
1 7   LEU n 
1 8   GLN n 
1 9   GLN n 
1 10  VAL n 
1 11  GLY n 
1 12  GLY n 
1 13  VAL n 
1 14  GLY n 
1 15  ARG n 
1 16  PHE n 
1 17  GLN n 
1 18  GLN n 
1 19  ILE n 
1 20  GLN n 
1 21  VAL n 
1 22  THR n 
1 23  LEU n 
1 24  VAL n 
1 25  VAL n 
1 26  LEU n 
1 27  PRO n 
1 28  LEU n 
1 29  LEU n 
1 30  LEU n 
1 31  MET n 
1 32  ALA n 
1 33  SER n 
1 34  HIS n 
1 35  ASN n 
1 36  THR n 
1 37  LEU n 
1 38  GLN n 
1 39  ASN n 
1 40  PHE n 
1 41  THR n 
1 42  ALA n 
1 43  ALA n 
1 44  ILE n 
1 45  PRO n 
1 46  THR n 
1 47  HIS n 
1 48  HIS n 
1 49  CYS n 
1 50  ARG n 
1 51  PRO n 
1 52  PRO n 
1 53  ALA n 
1 54  ASP n 
1 55  ALA n 
1 56  ASN n 
1 57  LEU n 
1 58  SER n 
1 59  LYS n 
1 60  ASN n 
1 61  GLY n 
1 62  GLY n 
1 63  LEU n 
1 64  GLU n 
1 65  VAL n 
1 66  TRP n 
1 67  LEU n 
1 68  PRO n 
1 69  ARG n 
1 70  ASP n 
1 71  ARG n 
1 72  GLN n 
1 73  GLY n 
1 74  GLN n 
1 75  PRO n 
1 76  GLU n 
1 77  SER n 
1 78  CYS n 
1 79  LEU n 
1 80  ARG n 
1 81  PHE n 
1 82  THR n 
1 83  SER n 
1 84  PRO n 
1 85  GLN n 
1 86  TRP n 
1 87  GLY n 
1 88  LEU n 
1 89  PRO n 
1 90  PHE n 
1 91  LEU n 
1 92  ASN n 
1 93  GLY n 
1 94  THR n 
1 95  GLU n 
1 96  ALA n 
1 97  ASN n 
1 98  GLY n 
1 99  THR n 
1 100 GLY n 
1 101 ALA n 
1 102 THR n 
1 103 GLU n 
1 104 PRO n 
1 105 CYS n 
1 106 THR n 
1 107 ASP n 
1 108 GLY n 
1 109 TRP n 
1 110 ILE n 
1 111 TYR n 
1 112 ASP n 
1 113 ASN n 
1 114 SER n 
1 115 THR n 
1 116 PHE n 
1 117 PRO n 
1 118 SER n 
1 119 THR n 
1 120 ILE n 
1 121 VAL n 
1 122 THR n 
1 123 GLU n 
1 124 TRP n 
1 125 ASP n 
1 126 LEU n 
1 127 VAL n 
1 128 CYS n 
1 129 SER n 
1 130 HIS n 
1 131 ARG n 
1 132 ALA n 
1 133 LEU n 
1 134 ARG n 
1 135 GLN n 
1 136 LEU n 
1 137 ALA n 
1 138 GLN n 
1 139 SER n 
1 140 LEU n 
1 141 TYR n 
1 142 MET n 
1 143 VAL n 
1 144 GLY n 
1 145 VAL n 
1 146 LEU n 
1 147 LEU n 
1 148 GLY n 
1 149 ALA n 
1 150 MET n 
1 151 VAL n 
1 152 PHE n 
1 153 GLY n 
1 154 TYR n 
1 155 LEU n 
1 156 ALA n 
1 157 ASP n 
1 158 ARG n 
1 159 LEU n 
1 160 GLY n 
1 161 ARG n 
1 162 ARG n 
1 163 LYS n 
1 164 VAL n 
1 165 LEU n 
1 166 ILE n 
1 167 LEU n 
1 168 ASN n 
1 169 TYR n 
1 170 LEU n 
1 171 GLN n 
1 172 THR n 
1 173 ALA n 
1 174 VAL n 
1 175 SER n 
1 176 GLY n 
1 177 THR n 
1 178 CYS n 
1 179 ALA n 
1 180 ALA n 
1 181 PHE n 
1 182 ALA n 
1 183 PRO n 
1 184 ASN n 
1 185 PHE n 
1 186 PRO n 
1 187 ILE n 
1 188 TYR n 
1 189 CYS n 
1 190 ALA n 
1 191 PHE n 
1 192 ARG n 
1 193 LEU n 
1 194 LEU n 
1 195 SER n 
1 196 GLY n 
1 197 MET n 
1 198 ALA n 
1 199 LEU n 
1 200 ALA n 
1 201 GLY n 
1 202 ILE n 
1 203 SER n 
1 204 LEU n 
1 205 ASN n 
1 206 CYS n 
1 207 MET n 
1 208 THR n 
1 209 LEU n 
1 210 ASN n 
1 211 VAL n 
1 212 GLU n 
1 213 TRP n 
1 214 MET n 
1 215 PRO n 
1 216 ILE n 
1 217 HIS n 
1 218 THR n 
1 219 ARG n 
1 220 ALA n 
1 221 CYS n 
1 222 VAL n 
1 223 GLY n 
1 224 THR n 
1 225 LEU n 
1 226 ILE n 
1 227 GLY n 
1 228 TYR n 
1 229 VAL n 
1 230 TYR n 
1 231 SER n 
1 232 LEU n 
1 233 GLY n 
1 234 GLN n 
1 235 PHE n 
1 236 LEU n 
1 237 LEU n 
1 238 ALA n 
1 239 GLY n 
1 240 VAL n 
1 241 ALA n 
1 242 TYR n 
1 243 ALA n 
1 244 VAL n 
1 245 PRO n 
1 246 HIS n 
1 247 TRP n 
1 248 ARG n 
1 249 HIS n 
1 250 LEU n 
1 251 GLN n 
1 252 LEU n 
1 253 LEU n 
1 254 VAL n 
1 255 SER n 
1 256 ALA n 
1 257 PRO n 
1 258 PHE n 
1 259 PHE n 
1 260 ALA n 
1 261 PHE n 
1 262 PHE n 
1 263 ILE n 
1 264 TYR n 
1 265 SER n 
1 266 TRP n 
1 267 PHE n 
1 268 PHE n 
1 269 ILE n 
1 270 GLU n 
1 271 SER n 
1 272 ALA n 
1 273 ARG n 
1 274 TRP n 
1 275 HIS n 
1 276 SER n 
1 277 SER n 
1 278 SER n 
1 279 GLY n 
1 280 ARG n 
1 281 LEU n 
1 282 ASP n 
1 283 LEU n 
1 284 THR n 
1 285 LEU n 
1 286 ARG n 
1 287 ALA n 
1 288 LEU n 
1 289 GLN n 
1 290 ARG n 
1 291 VAL n 
1 292 ALA n 
1 293 ARG n 
1 294 ILE n 
1 295 ASN n 
1 296 GLY n 
1 297 LYS n 
1 298 ARG n 
1 299 GLU n 
1 300 GLU n 
1 301 GLY n 
1 302 ALA n 
1 303 LYS n 
1 304 LEU n 
1 305 SER n 
1 306 MET n 
1 307 GLU n 
1 308 VAL n 
1 309 LEU n 
1 310 ARG n 
1 311 ALA n 
1 312 SER n 
1 313 LEU n 
1 314 GLN n 
1 315 LYS n 
1 316 GLU n 
1 317 LEU n 
1 318 THR n 
1 319 MET n 
1 320 GLY n 
1 321 LYS n 
1 322 GLY n 
1 323 GLN n 
1 324 ALA n 
1 325 SER n 
1 326 ALA n 
1 327 MET n 
1 328 GLU n 
1 329 LEU n 
1 330 LEU n 
1 331 ARG n 
1 332 CYS n 
1 333 PRO n 
1 334 THR n 
1 335 LEU n 
1 336 ARG n 
1 337 HIS n 
1 338 LEU n 
1 339 PHE n 
1 340 LEU n 
1 341 CYS n 
1 342 LEU n 
1 343 SER n 
1 344 MET n 
1 345 LEU n 
1 346 TRP n 
1 347 PHE n 
1 348 ALA n 
1 349 THR n 
1 350 SER n 
1 351 PHE n 
1 352 ALA n 
1 353 TYR n 
1 354 TYR n 
1 355 GLY n 
1 356 LEU n 
1 357 VAL n 
1 358 MET n 
1 359 ASP n 
1 360 LEU n 
1 361 GLN n 
1 362 GLY n 
1 363 PHE n 
1 364 GLY n 
1 365 VAL n 
1 366 SER n 
1 367 ILE n 
1 368 TYR n 
1 369 LEU n 
1 370 ILE n 
1 371 GLN n 
1 372 VAL n 
1 373 ILE n 
1 374 PHE n 
1 375 GLY n 
1 376 ALA n 
1 377 VAL n 
1 378 ASP n 
1 379 LEU n 
1 380 PRO n 
1 381 ALA n 
1 382 LYS n 
1 383 LEU n 
1 384 VAL n 
1 385 GLY n 
1 386 PHE n 
1 387 LEU n 
1 388 VAL n 
1 389 ILE n 
1 390 ASN n 
1 391 SER n 
1 392 LEU n 
1 393 GLY n 
1 394 ARG n 
1 395 ARG n 
1 396 PRO n 
1 397 ALA n 
1 398 GLN n 
1 399 MET n 
1 400 ALA n 
1 401 ALA n 
1 402 LEU n 
1 403 LEU n 
1 404 LEU n 
1 405 ALA n 
1 406 GLY n 
1 407 ILE n 
1 408 CYS n 
1 409 ILE n 
1 410 LEU n 
1 411 LEU n 
1 412 ASN n 
1 413 GLY n 
1 414 VAL n 
1 415 ILE n 
1 416 PRO n 
1 417 GLN n 
1 418 ASP n 
1 419 GLN n 
1 420 SER n 
1 421 ILE n 
1 422 VAL n 
1 423 ARG n 
1 424 THR n 
1 425 SER n 
1 426 LEU n 
1 427 ALA n 
1 428 VAL n 
1 429 LEU n 
1 430 GLY n 
1 431 LYS n 
1 432 GLY n 
1 433 CYS n 
1 434 LEU n 
1 435 ALA n 
1 436 ALA n 
1 437 SER n 
1 438 PHE n 
1 439 ASN n 
1 440 CYS n 
1 441 ILE n 
1 442 PHE n 
1 443 LEU n 
1 444 TYR n 
1 445 THR n 
1 446 GLY n 
1 447 GLU n 
1 448 LEU n 
1 449 TYR n 
1 450 PRO n 
1 451 THR n 
1 452 MET n 
1 453 ILE n 
1 454 ARG n 
1 455 GLN n 
1 456 THR n 
1 457 GLY n 
1 458 MET n 
1 459 GLY n 
1 460 MET n 
1 461 GLY n 
1 462 SER n 
1 463 THR n 
1 464 MET n 
1 465 ALA n 
1 466 ARG n 
1 467 VAL n 
1 468 GLY n 
1 469 SER n 
1 470 ILE n 
1 471 VAL n 
1 472 SER n 
1 473 PRO n 
1 474 LEU n 
1 475 VAL n 
1 476 SER n 
1 477 MET n 
1 478 THR n 
1 479 ALA n 
1 480 GLU n 
1 481 LEU n 
1 482 TYR n 
1 483 PRO n 
1 484 SER n 
1 485 MET n 
1 486 PRO n 
1 487 LEU n 
1 488 PHE n 
1 489 ILE n 
1 490 TYR n 
1 491 GLY n 
1 492 ALA n 
1 493 VAL n 
1 494 PRO n 
1 495 VAL n 
1 496 ALA n 
1 497 ALA n 
1 498 SER n 
1 499 ALA n 
1 500 VAL n 
1 501 THR n 
1 502 VAL n 
1 503 LEU n 
1 504 LEU n 
1 505 PRO n 
1 506 GLU n 
1 507 THR n 
1 508 LEU n 
1 509 GLY n 
1 510 GLN n 
1 511 PRO n 
1 512 LEU n 
1 513 PRO n 
1 514 ASP n 
1 515 THR n 
1 516 VAL n 
1 517 GLN n 
1 518 ASP n 
1 519 LEU n 
1 520 GLU n 
1 521 SER n 
1 522 ARG n 
1 523 LYS n 
1 524 GLY n 
1 525 LYS n 
1 526 GLN n 
1 527 THR n 
1 528 ARG n 
1 529 GLN n 
1 530 GLN n 
1 531 GLN n 
1 532 GLU n 
1 533 HIS n 
1 534 GLN n 
1 535 LYS n 
1 536 TYR n 
1 537 MET n 
1 538 VAL n 
1 539 PRO n 
1 540 LEU n 
1 541 GLN n 
1 542 ALA n 
1 543 SER n 
1 544 ALA n 
1 545 GLN n 
1 546 GLU n 
1 547 LYS n 
1 548 ASN n 
1 549 GLY n 
1 550 LEU n 
1 551 HIS n 
1 552 HIS n 
1 553 HIS n 
1 554 HIS n 
1 555 HIS n 
1 556 HIS n 
1 557 HIS n 
1 558 HIS n 
1 559 HIS n 
1 560 HIS n 
1 561 GLY n 
1 562 SER n 
1 563 VAL n 
1 564 GLU n 
1 565 ASP n 
1 566 TYR n 
1 567 LYS n 
1 568 ASP n 
1 569 ASP n 
1 570 ASP n 
1 571 ASP n 
1 572 LYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   572 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'SLC22A6, OAT1, PAHT' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   1   MET MET A . n 
A 1 2   ALA 2   2   2   ALA ALA A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ASN 4   4   4   ASN ASN A . n 
A 1 5   ASP 5   5   5   ASP ASP A . n 
A 1 6   LEU 6   6   6   LEU LEU A . n 
A 1 7   LEU 7   7   7   LEU LEU A . n 
A 1 8   GLN 8   8   8   GLN GLN A . n 
A 1 9   GLN 9   9   9   GLN GLN A . n 
A 1 10  VAL 10  10  10  VAL VAL A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  GLY 12  12  12  GLY GLY A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLY 14  14  14  GLY GLY A . n 
A 1 15  ARG 15  15  15  ARG ARG A . n 
A 1 16  PHE 16  16  16  PHE PHE A . n 
A 1 17  GLN 17  17  17  GLN GLN A . n 
A 1 18  GLN 18  18  18  GLN GLN A . n 
A 1 19  ILE 19  19  19  ILE ILE A . n 
A 1 20  GLN 20  20  20  GLN GLN A . n 
A 1 21  VAL 21  21  21  VAL VAL A . n 
A 1 22  THR 22  22  22  THR THR A . n 
A 1 23  LEU 23  23  23  LEU LEU A . n 
A 1 24  VAL 24  24  24  VAL VAL A . n 
A 1 25  VAL 25  25  25  VAL VAL A . n 
A 1 26  LEU 26  26  26  LEU LEU A . n 
A 1 27  PRO 27  27  27  PRO PRO A . n 
A 1 28  LEU 28  28  28  LEU LEU A . n 
A 1 29  LEU 29  29  29  LEU LEU A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  MET 31  31  31  MET MET A . n 
A 1 32  ALA 32  32  32  ALA ALA A . n 
A 1 33  SER 33  33  33  SER SER A . n 
A 1 34  HIS 34  34  34  HIS HIS A . n 
A 1 35  ASN 35  35  35  ASN ASN A . n 
A 1 36  THR 36  36  36  THR THR A . n 
A 1 37  LEU 37  37  37  LEU LEU A . n 
A 1 38  GLN 38  38  38  GLN GLN A . n 
A 1 39  ASN 39  39  39  ASN ASN A . n 
A 1 40  PHE 40  40  40  PHE PHE A . n 
A 1 41  THR 41  41  41  THR THR A . n 
A 1 42  ALA 42  42  42  ALA ALA A . n 
A 1 43  ALA 43  43  43  ALA ALA A . n 
A 1 44  ILE 44  44  44  ILE ILE A . n 
A 1 45  PRO 45  45  45  PRO PRO A . n 
A 1 46  THR 46  46  46  THR THR A . n 
A 1 47  HIS 47  47  47  HIS HIS A . n 
A 1 48  HIS 48  48  48  HIS HIS A . n 
A 1 49  CYS 49  49  49  CYS CYS A . n 
A 1 50  ARG 50  50  50  ARG ARG A . n 
A 1 51  PRO 51  51  51  PRO PRO A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ALA 53  53  53  ALA ALA A . n 
A 1 54  ASP 54  54  54  ASP ASP A . n 
A 1 55  ALA 55  55  55  ALA ALA A . n 
A 1 56  ASN 56  56  56  ASN ASN A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  SER 58  58  58  SER SER A . n 
A 1 59  LYS 59  59  59  LYS LYS A . n 
A 1 60  ASN 60  60  60  ASN ASN A . n 
A 1 61  GLY 61  61  61  GLY GLY A . n 
A 1 62  GLY 62  62  62  GLY GLY A . n 
A 1 63  LEU 63  63  63  LEU LEU A . n 
A 1 64  GLU 64  64  64  GLU GLU A . n 
A 1 65  VAL 65  65  65  VAL VAL A . n 
A 1 66  TRP 66  66  66  TRP TRP A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  PRO 68  68  68  PRO PRO A . n 
A 1 69  ARG 69  69  69  ARG ARG A . n 
A 1 70  ASP 70  70  70  ASP ASP A . n 
A 1 71  ARG 71  71  71  ARG ARG A . n 
A 1 72  GLN 72  72  72  GLN GLN A . n 
A 1 73  GLY 73  73  73  GLY GLY A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  PRO 75  75  75  PRO PRO A . n 
A 1 76  GLU 76  76  76  GLU GLU A . n 
A 1 77  SER 77  77  77  SER SER A . n 
A 1 78  CYS 78  78  78  CYS CYS A . n 
A 1 79  LEU 79  79  79  LEU LEU A . n 
A 1 80  ARG 80  80  80  ARG ARG A . n 
A 1 81  PHE 81  81  81  PHE PHE A . n 
A 1 82  THR 82  82  82  THR THR A . n 
A 1 83  SER 83  83  83  SER SER A . n 
A 1 84  PRO 84  84  84  PRO PRO A . n 
A 1 85  GLN 85  85  85  GLN GLN A . n 
A 1 86  TRP 86  86  86  TRP TRP A . n 
A 1 87  GLY 87  87  87  GLY GLY A . n 
A 1 88  LEU 88  88  ?   ?   ?   A . n 
A 1 89  PRO 89  89  ?   ?   ?   A . n 
A 1 90  PHE 90  90  ?   ?   ?   A . n 
A 1 91  LEU 91  91  ?   ?   ?   A . n 
A 1 92  ASN 92  92  ?   ?   ?   A . n 
A 1 93  GLY 93  93  ?   ?   ?   A . n 
A 1 94  THR 94  94  ?   ?   ?   A . n 
A 1 95  GLU 95  95  ?   ?   ?   A . n 
A 1 96  ALA 96  96  ?   ?   ?   A . n 
A 1 97  ASN 97  97  ?   ?   ?   A . n 
A 1 98  GLY 98  98  ?   ?   ?   A . n 
A 1 99  THR 99  99  99  THR THR A . n 
A 1 100 GLY 100 100 100 GLY GLY A . n 
A 1 101 ALA 101 101 101 ALA ALA A . n 
A 1 102 THR 102 102 102 THR THR A . n 
A 1 103 GLU 103 103 103 GLU GLU A . n 
A 1 104 PRO 104 104 104 PRO PRO A . n 
A 1 105 CYS 105 105 105 CYS CYS A . n 
A 1 106 THR 106 106 106 THR THR A . n 
A 1 107 ASP 107 107 107 ASP ASP A . n 
A 1 108 GLY 108 108 108 GLY GLY A . n 
A 1 109 TRP 109 109 109 TRP TRP A . n 
A 1 110 ILE 110 110 110 ILE ILE A . n 
A 1 111 TYR 111 111 111 TYR TYR A . n 
A 1 112 ASP 112 112 112 ASP ASP A . n 
A 1 113 ASN 113 113 113 ASN ASN A . n 
A 1 114 SER 114 114 114 SER SER A . n 
A 1 115 THR 115 115 115 THR THR A . n 
A 1 116 PHE 116 116 116 PHE PHE A . n 
A 1 117 PRO 117 117 117 PRO PRO A . n 
A 1 118 SER 118 118 118 SER SER A . n 
A 1 119 THR 119 119 119 THR THR A . n 
A 1 120 ILE 120 120 120 ILE ILE A . n 
A 1 121 VAL 121 121 121 VAL VAL A . n 
A 1 122 THR 122 122 122 THR THR A . n 
A 1 123 GLU 123 123 123 GLU GLU A . n 
A 1 124 TRP 124 124 124 TRP TRP A . n 
A 1 125 ASP 125 125 125 ASP ASP A . n 
A 1 126 LEU 126 126 126 LEU LEU A . n 
A 1 127 VAL 127 127 127 VAL VAL A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 SER 129 129 129 SER SER A . n 
A 1 130 HIS 130 130 130 HIS HIS A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 ALA 132 132 132 ALA ALA A . n 
A 1 133 LEU 133 133 133 LEU LEU A . n 
A 1 134 ARG 134 134 134 ARG ARG A . n 
A 1 135 GLN 135 135 135 GLN GLN A . n 
A 1 136 LEU 136 136 136 LEU LEU A . n 
A 1 137 ALA 137 137 137 ALA ALA A . n 
A 1 138 GLN 138 138 138 GLN GLN A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 LEU 140 140 140 LEU LEU A . n 
A 1 141 TYR 141 141 141 TYR TYR A . n 
A 1 142 MET 142 142 142 MET MET A . n 
A 1 143 VAL 143 143 143 VAL VAL A . n 
A 1 144 GLY 144 144 144 GLY GLY A . n 
A 1 145 VAL 145 145 145 VAL VAL A . n 
A 1 146 LEU 146 146 146 LEU LEU A . n 
A 1 147 LEU 147 147 147 LEU LEU A . n 
A 1 148 GLY 148 148 148 GLY GLY A . n 
A 1 149 ALA 149 149 149 ALA ALA A . n 
A 1 150 MET 150 150 150 MET MET A . n 
A 1 151 VAL 151 151 151 VAL VAL A . n 
A 1 152 PHE 152 152 152 PHE PHE A . n 
A 1 153 GLY 153 153 153 GLY GLY A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 LEU 155 155 155 LEU LEU A . n 
A 1 156 ALA 156 156 156 ALA ALA A . n 
A 1 157 ASP 157 157 157 ASP ASP A . n 
A 1 158 ARG 158 158 158 ARG ARG A . n 
A 1 159 LEU 159 159 159 LEU LEU A . n 
A 1 160 GLY 160 160 160 GLY GLY A . n 
A 1 161 ARG 161 161 161 ARG ARG A . n 
A 1 162 ARG 162 162 162 ARG ARG A . n 
A 1 163 LYS 163 163 163 LYS LYS A . n 
A 1 164 VAL 164 164 164 VAL VAL A . n 
A 1 165 LEU 165 165 165 LEU LEU A . n 
A 1 166 ILE 166 166 166 ILE ILE A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 ASN 168 168 168 ASN ASN A . n 
A 1 169 TYR 169 169 169 TYR TYR A . n 
A 1 170 LEU 170 170 170 LEU LEU A . n 
A 1 171 GLN 171 171 171 GLN GLN A . n 
A 1 172 THR 172 172 172 THR THR A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 VAL 174 174 174 VAL VAL A . n 
A 1 175 SER 175 175 175 SER SER A . n 
A 1 176 GLY 176 176 176 GLY GLY A . n 
A 1 177 THR 177 177 177 THR THR A . n 
A 1 178 CYS 178 178 178 CYS CYS A . n 
A 1 179 ALA 179 179 179 ALA ALA A . n 
A 1 180 ALA 180 180 180 ALA ALA A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 ALA 182 182 182 ALA ALA A . n 
A 1 183 PRO 183 183 183 PRO PRO A . n 
A 1 184 ASN 184 184 184 ASN ASN A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 PRO 186 186 186 PRO PRO A . n 
A 1 187 ILE 187 187 187 ILE ILE A . n 
A 1 188 TYR 188 188 188 TYR TYR A . n 
A 1 189 CYS 189 189 189 CYS CYS A . n 
A 1 190 ALA 190 190 190 ALA ALA A . n 
A 1 191 PHE 191 191 191 PHE PHE A . n 
A 1 192 ARG 192 192 192 ARG ARG A . n 
A 1 193 LEU 193 193 193 LEU LEU A . n 
A 1 194 LEU 194 194 194 LEU LEU A . n 
A 1 195 SER 195 195 195 SER SER A . n 
A 1 196 GLY 196 196 196 GLY GLY A . n 
A 1 197 MET 197 197 197 MET MET A . n 
A 1 198 ALA 198 198 198 ALA ALA A . n 
A 1 199 LEU 199 199 199 LEU LEU A . n 
A 1 200 ALA 200 200 200 ALA ALA A . n 
A 1 201 GLY 201 201 201 GLY GLY A . n 
A 1 202 ILE 202 202 202 ILE ILE A . n 
A 1 203 SER 203 203 203 SER SER A . n 
A 1 204 LEU 204 204 204 LEU LEU A . n 
A 1 205 ASN 205 205 205 ASN ASN A . n 
A 1 206 CYS 206 206 206 CYS CYS A . n 
A 1 207 MET 207 207 207 MET MET A . n 
A 1 208 THR 208 208 208 THR THR A . n 
A 1 209 LEU 209 209 209 LEU LEU A . n 
A 1 210 ASN 210 210 210 ASN ASN A . n 
A 1 211 VAL 211 211 211 VAL VAL A . n 
A 1 212 GLU 212 212 212 GLU GLU A . n 
A 1 213 TRP 213 213 213 TRP TRP A . n 
A 1 214 MET 214 214 214 MET MET A . n 
A 1 215 PRO 215 215 215 PRO PRO A . n 
A 1 216 ILE 216 216 216 ILE ILE A . n 
A 1 217 HIS 217 217 217 HIS HIS A . n 
A 1 218 THR 218 218 218 THR THR A . n 
A 1 219 ARG 219 219 219 ARG ARG A . n 
A 1 220 ALA 220 220 220 ALA ALA A . n 
A 1 221 CYS 221 221 221 CYS CYS A . n 
A 1 222 VAL 222 222 222 VAL VAL A . n 
A 1 223 GLY 223 223 223 GLY GLY A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 LEU 225 225 225 LEU LEU A . n 
A 1 226 ILE 226 226 226 ILE ILE A . n 
A 1 227 GLY 227 227 227 GLY GLY A . n 
A 1 228 TYR 228 228 228 TYR TYR A . n 
A 1 229 VAL 229 229 229 VAL VAL A . n 
A 1 230 TYR 230 230 230 TYR TYR A . n 
A 1 231 SER 231 231 231 SER SER A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 GLY 233 233 233 GLY GLY A . n 
A 1 234 GLN 234 234 234 GLN GLN A . n 
A 1 235 PHE 235 235 235 PHE PHE A . n 
A 1 236 LEU 236 236 236 LEU LEU A . n 
A 1 237 LEU 237 237 237 LEU LEU A . n 
A 1 238 ALA 238 238 238 ALA ALA A . n 
A 1 239 GLY 239 239 239 GLY GLY A . n 
A 1 240 VAL 240 240 240 VAL VAL A . n 
A 1 241 ALA 241 241 241 ALA ALA A . n 
A 1 242 TYR 242 242 242 TYR TYR A . n 
A 1 243 ALA 243 243 243 ALA ALA A . n 
A 1 244 VAL 244 244 244 VAL VAL A . n 
A 1 245 PRO 245 245 245 PRO PRO A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 TRP 247 247 247 TRP TRP A . n 
A 1 248 ARG 248 248 248 ARG ARG A . n 
A 1 249 HIS 249 249 249 HIS HIS A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLN 251 251 251 GLN GLN A . n 
A 1 252 LEU 252 252 252 LEU LEU A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 VAL 254 254 254 VAL VAL A . n 
A 1 255 SER 255 255 255 SER SER A . n 
A 1 256 ALA 256 256 256 ALA ALA A . n 
A 1 257 PRO 257 257 257 PRO PRO A . n 
A 1 258 PHE 258 258 258 PHE PHE A . n 
A 1 259 PHE 259 259 259 PHE PHE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 PHE 261 261 261 PHE PHE A . n 
A 1 262 PHE 262 262 262 PHE PHE A . n 
A 1 263 ILE 263 263 263 ILE ILE A . n 
A 1 264 TYR 264 264 264 TYR TYR A . n 
A 1 265 SER 265 265 265 SER SER A . n 
A 1 266 TRP 266 266 266 TRP TRP A . n 
A 1 267 PHE 267 267 267 PHE PHE A . n 
A 1 268 PHE 268 268 268 PHE PHE A . n 
A 1 269 ILE 269 269 269 ILE ILE A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 SER 271 271 271 SER SER A . n 
A 1 272 ALA 272 272 272 ALA ALA A . n 
A 1 273 ARG 273 273 273 ARG ARG A . n 
A 1 274 TRP 274 274 274 TRP TRP A . n 
A 1 275 HIS 275 275 275 HIS HIS A . n 
A 1 276 SER 276 276 276 SER SER A . n 
A 1 277 SER 277 277 277 SER SER A . n 
A 1 278 SER 278 278 278 SER SER A . n 
A 1 279 GLY 279 279 279 GLY GLY A . n 
A 1 280 ARG 280 280 280 ARG ARG A . n 
A 1 281 LEU 281 281 281 LEU LEU A . n 
A 1 282 ASP 282 282 282 ASP ASP A . n 
A 1 283 LEU 283 283 283 LEU LEU A . n 
A 1 284 THR 284 284 284 THR THR A . n 
A 1 285 LEU 285 285 285 LEU LEU A . n 
A 1 286 ARG 286 286 286 ARG ARG A . n 
A 1 287 ALA 287 287 287 ALA ALA A . n 
A 1 288 LEU 288 288 288 LEU LEU A . n 
A 1 289 GLN 289 289 289 GLN GLN A . n 
A 1 290 ARG 290 290 290 ARG ARG A . n 
A 1 291 VAL 291 291 291 VAL VAL A . n 
A 1 292 ALA 292 292 292 ALA ALA A . n 
A 1 293 ARG 293 293 293 ARG ARG A . n 
A 1 294 ILE 294 294 294 ILE ILE A . n 
A 1 295 ASN 295 295 295 ASN ASN A . n 
A 1 296 GLY 296 296 296 GLY GLY A . n 
A 1 297 LYS 297 297 297 LYS LYS A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLU 299 299 299 GLU GLU A . n 
A 1 300 GLU 300 300 300 GLU GLU A . n 
A 1 301 GLY 301 301 301 GLY GLY A . n 
A 1 302 ALA 302 302 302 ALA ALA A . n 
A 1 303 LYS 303 303 303 LYS LYS A . n 
A 1 304 LEU 304 304 304 LEU LEU A . n 
A 1 305 SER 305 305 305 SER SER A . n 
A 1 306 MET 306 306 306 MET MET A . n 
A 1 307 GLU 307 307 307 GLU GLU A . n 
A 1 308 VAL 308 308 308 VAL VAL A . n 
A 1 309 LEU 309 309 309 LEU LEU A . n 
A 1 310 ARG 310 310 310 ARG ARG A . n 
A 1 311 ALA 311 311 311 ALA ALA A . n 
A 1 312 SER 312 312 312 SER SER A . n 
A 1 313 LEU 313 313 313 LEU LEU A . n 
A 1 314 GLN 314 314 314 GLN GLN A . n 
A 1 315 LYS 315 315 315 LYS LYS A . n 
A 1 316 GLU 316 316 316 GLU GLU A . n 
A 1 317 LEU 317 317 317 LEU LEU A . n 
A 1 318 THR 318 318 ?   ?   ?   A . n 
A 1 319 MET 319 319 ?   ?   ?   A . n 
A 1 320 GLY 320 320 ?   ?   ?   A . n 
A 1 321 LYS 321 321 ?   ?   ?   A . n 
A 1 322 GLY 322 322 ?   ?   ?   A . n 
A 1 323 GLN 323 323 323 GLN GLN A . n 
A 1 324 ALA 324 324 324 ALA ALA A . n 
A 1 325 SER 325 325 325 SER SER A . n 
A 1 326 ALA 326 326 326 ALA ALA A . n 
A 1 327 MET 327 327 327 MET MET A . n 
A 1 328 GLU 328 328 328 GLU GLU A . n 
A 1 329 LEU 329 329 329 LEU LEU A . n 
A 1 330 LEU 330 330 330 LEU LEU A . n 
A 1 331 ARG 331 331 331 ARG ARG A . n 
A 1 332 CYS 332 332 332 CYS CYS A . n 
A 1 333 PRO 333 333 333 PRO PRO A . n 
A 1 334 THR 334 334 334 THR THR A . n 
A 1 335 LEU 335 335 335 LEU LEU A . n 
A 1 336 ARG 336 336 336 ARG ARG A . n 
A 1 337 HIS 337 337 337 HIS HIS A . n 
A 1 338 LEU 338 338 338 LEU LEU A . n 
A 1 339 PHE 339 339 339 PHE PHE A . n 
A 1 340 LEU 340 340 340 LEU LEU A . n 
A 1 341 CYS 341 341 341 CYS CYS A . n 
A 1 342 LEU 342 342 342 LEU LEU A . n 
A 1 343 SER 343 343 343 SER SER A . n 
A 1 344 MET 344 344 344 MET MET A . n 
A 1 345 LEU 345 345 345 LEU LEU A . n 
A 1 346 TRP 346 346 346 TRP TRP A . n 
A 1 347 PHE 347 347 347 PHE PHE A . n 
A 1 348 ALA 348 348 348 ALA ALA A . n 
A 1 349 THR 349 349 349 THR THR A . n 
A 1 350 SER 350 350 350 SER SER A . n 
A 1 351 PHE 351 351 351 PHE PHE A . n 
A 1 352 ALA 352 352 352 ALA ALA A . n 
A 1 353 TYR 353 353 353 TYR TYR A . n 
A 1 354 TYR 354 354 354 TYR TYR A . n 
A 1 355 GLY 355 355 355 GLY GLY A . n 
A 1 356 LEU 356 356 356 LEU LEU A . n 
A 1 357 VAL 357 357 357 VAL VAL A . n 
A 1 358 MET 358 358 358 MET MET A . n 
A 1 359 ASP 359 359 359 ASP ASP A . n 
A 1 360 LEU 360 360 360 LEU LEU A . n 
A 1 361 GLN 361 361 361 GLN GLN A . n 
A 1 362 GLY 362 362 362 GLY GLY A . n 
A 1 363 PHE 363 363 363 PHE PHE A . n 
A 1 364 GLY 364 364 364 GLY GLY A . n 
A 1 365 VAL 365 365 365 VAL VAL A . n 
A 1 366 SER 366 366 366 SER SER A . n 
A 1 367 ILE 367 367 367 ILE ILE A . n 
A 1 368 TYR 368 368 368 TYR TYR A . n 
A 1 369 LEU 369 369 369 LEU LEU A . n 
A 1 370 ILE 370 370 370 ILE ILE A . n 
A 1 371 GLN 371 371 371 GLN GLN A . n 
A 1 372 VAL 372 372 372 VAL VAL A . n 
A 1 373 ILE 373 373 373 ILE ILE A . n 
A 1 374 PHE 374 374 374 PHE PHE A . n 
A 1 375 GLY 375 375 375 GLY GLY A . n 
A 1 376 ALA 376 376 376 ALA ALA A . n 
A 1 377 VAL 377 377 377 VAL VAL A . n 
A 1 378 ASP 378 378 378 ASP ASP A . n 
A 1 379 LEU 379 379 379 LEU LEU A . n 
A 1 380 PRO 380 380 380 PRO PRO A . n 
A 1 381 ALA 381 381 381 ALA ALA A . n 
A 1 382 LYS 382 382 382 LYS LYS A . n 
A 1 383 LEU 383 383 383 LEU LEU A . n 
A 1 384 VAL 384 384 384 VAL VAL A . n 
A 1 385 GLY 385 385 385 GLY GLY A . n 
A 1 386 PHE 386 386 386 PHE PHE A . n 
A 1 387 LEU 387 387 387 LEU LEU A . n 
A 1 388 VAL 388 388 388 VAL VAL A . n 
A 1 389 ILE 389 389 389 ILE ILE A . n 
A 1 390 ASN 390 390 390 ASN ASN A . n 
A 1 391 SER 391 391 391 SER SER A . n 
A 1 392 LEU 392 392 392 LEU LEU A . n 
A 1 393 GLY 393 393 393 GLY GLY A . n 
A 1 394 ARG 394 394 394 ARG ARG A . n 
A 1 395 ARG 395 395 395 ARG ARG A . n 
A 1 396 PRO 396 396 396 PRO PRO A . n 
A 1 397 ALA 397 397 397 ALA ALA A . n 
A 1 398 GLN 398 398 398 GLN GLN A . n 
A 1 399 MET 399 399 399 MET MET A . n 
A 1 400 ALA 400 400 400 ALA ALA A . n 
A 1 401 ALA 401 401 401 ALA ALA A . n 
A 1 402 LEU 402 402 402 LEU LEU A . n 
A 1 403 LEU 403 403 403 LEU LEU A . n 
A 1 404 LEU 404 404 404 LEU LEU A . n 
A 1 405 ALA 405 405 405 ALA ALA A . n 
A 1 406 GLY 406 406 406 GLY GLY A . n 
A 1 407 ILE 407 407 407 ILE ILE A . n 
A 1 408 CYS 408 408 408 CYS CYS A . n 
A 1 409 ILE 409 409 409 ILE ILE A . n 
A 1 410 LEU 410 410 410 LEU LEU A . n 
A 1 411 LEU 411 411 411 LEU LEU A . n 
A 1 412 ASN 412 412 412 ASN ASN A . n 
A 1 413 GLY 413 413 413 GLY GLY A . n 
A 1 414 VAL 414 414 414 VAL VAL A . n 
A 1 415 ILE 415 415 415 ILE ILE A . n 
A 1 416 PRO 416 416 416 PRO PRO A . n 
A 1 417 GLN 417 417 417 GLN GLN A . n 
A 1 418 ASP 418 418 418 ASP ASP A . n 
A 1 419 GLN 419 419 419 GLN GLN A . n 
A 1 420 SER 420 420 420 SER SER A . n 
A 1 421 ILE 421 421 421 ILE ILE A . n 
A 1 422 VAL 422 422 422 VAL VAL A . n 
A 1 423 ARG 423 423 423 ARG ARG A . n 
A 1 424 THR 424 424 424 THR THR A . n 
A 1 425 SER 425 425 425 SER SER A . n 
A 1 426 LEU 426 426 426 LEU LEU A . n 
A 1 427 ALA 427 427 427 ALA ALA A . n 
A 1 428 VAL 428 428 428 VAL VAL A . n 
A 1 429 LEU 429 429 429 LEU LEU A . n 
A 1 430 GLY 430 430 430 GLY GLY A . n 
A 1 431 LYS 431 431 431 LYS LYS A . n 
A 1 432 GLY 432 432 432 GLY GLY A . n 
A 1 433 CYS 433 433 433 CYS CYS A . n 
A 1 434 LEU 434 434 434 LEU LEU A . n 
A 1 435 ALA 435 435 435 ALA ALA A . n 
A 1 436 ALA 436 436 436 ALA ALA A . n 
A 1 437 SER 437 437 437 SER SER A . n 
A 1 438 PHE 438 438 438 PHE PHE A . n 
A 1 439 ASN 439 439 439 ASN ASN A . n 
A 1 440 CYS 440 440 440 CYS CYS A . n 
A 1 441 ILE 441 441 441 ILE ILE A . n 
A 1 442 PHE 442 442 442 PHE PHE A . n 
A 1 443 LEU 443 443 443 LEU LEU A . n 
A 1 444 TYR 444 444 444 TYR TYR A . n 
A 1 445 THR 445 445 445 THR THR A . n 
A 1 446 GLY 446 446 446 GLY GLY A . n 
A 1 447 GLU 447 447 447 GLU GLU A . n 
A 1 448 LEU 448 448 448 LEU LEU A . n 
A 1 449 TYR 449 449 449 TYR TYR A . n 
A 1 450 PRO 450 450 450 PRO PRO A . n 
A 1 451 THR 451 451 451 THR THR A . n 
A 1 452 MET 452 452 452 MET MET A . n 
A 1 453 ILE 453 453 453 ILE ILE A . n 
A 1 454 ARG 454 454 454 ARG ARG A . n 
A 1 455 GLN 455 455 455 GLN GLN A . n 
A 1 456 THR 456 456 456 THR THR A . n 
A 1 457 GLY 457 457 457 GLY GLY A . n 
A 1 458 MET 458 458 458 MET MET A . n 
A 1 459 GLY 459 459 459 GLY GLY A . n 
A 1 460 MET 460 460 460 MET MET A . n 
A 1 461 GLY 461 461 461 GLY GLY A . n 
A 1 462 SER 462 462 462 SER SER A . n 
A 1 463 THR 463 463 463 THR THR A . n 
A 1 464 MET 464 464 464 MET MET A . n 
A 1 465 ALA 465 465 465 ALA ALA A . n 
A 1 466 ARG 466 466 466 ARG ARG A . n 
A 1 467 VAL 467 467 467 VAL VAL A . n 
A 1 468 GLY 468 468 468 GLY GLY A . n 
A 1 469 SER 469 469 469 SER SER A . n 
A 1 470 ILE 470 470 470 ILE ILE A . n 
A 1 471 VAL 471 471 471 VAL VAL A . n 
A 1 472 SER 472 472 472 SER SER A . n 
A 1 473 PRO 473 473 473 PRO PRO A . n 
A 1 474 LEU 474 474 474 LEU LEU A . n 
A 1 475 VAL 475 475 475 VAL VAL A . n 
A 1 476 SER 476 476 476 SER SER A . n 
A 1 477 MET 477 477 477 MET MET A . n 
A 1 478 THR 478 478 478 THR THR A . n 
A 1 479 ALA 479 479 479 ALA ALA A . n 
A 1 480 GLU 480 480 480 GLU GLU A . n 
A 1 481 LEU 481 481 481 LEU LEU A . n 
A 1 482 TYR 482 482 482 TYR TYR A . n 
A 1 483 PRO 483 483 483 PRO PRO A . n 
A 1 484 SER 484 484 484 SER SER A . n 
A 1 485 MET 485 485 485 MET MET A . n 
A 1 486 PRO 486 486 486 PRO PRO A . n 
A 1 487 LEU 487 487 487 LEU LEU A . n 
A 1 488 PHE 488 488 488 PHE PHE A . n 
A 1 489 ILE 489 489 489 ILE ILE A . n 
A 1 490 TYR 490 490 490 TYR TYR A . n 
A 1 491 GLY 491 491 491 GLY GLY A . n 
A 1 492 ALA 492 492 492 ALA ALA A . n 
A 1 493 VAL 493 493 493 VAL VAL A . n 
A 1 494 PRO 494 494 494 PRO PRO A . n 
A 1 495 VAL 495 495 495 VAL VAL A . n 
A 1 496 ALA 496 496 496 ALA ALA A . n 
A 1 497 ALA 497 497 497 ALA ALA A . n 
A 1 498 SER 498 498 498 SER SER A . n 
A 1 499 ALA 499 499 499 ALA ALA A . n 
A 1 500 VAL 500 500 500 VAL VAL A . n 
A 1 501 THR 501 501 501 THR THR A . n 
A 1 502 VAL 502 502 502 VAL VAL A . n 
A 1 503 LEU 503 503 503 LEU LEU A . n 
A 1 504 LEU 504 504 504 LEU LEU A . n 
A 1 505 PRO 505 505 505 PRO PRO A . n 
A 1 506 GLU 506 506 506 GLU GLU A . n 
A 1 507 THR 507 507 507 THR THR A . n 
A 1 508 LEU 508 508 508 LEU LEU A . n 
A 1 509 GLY 509 509 509 GLY GLY A . n 
A 1 510 GLN 510 510 510 GLN GLN A . n 
A 1 511 PRO 511 511 511 PRO PRO A . n 
A 1 512 LEU 512 512 512 LEU LEU A . n 
A 1 513 PRO 513 513 513 PRO PRO A . n 
A 1 514 ASP 514 514 514 ASP ASP A . n 
A 1 515 THR 515 515 515 THR THR A . n 
A 1 516 VAL 516 516 516 VAL VAL A . n 
A 1 517 GLN 517 517 517 GLN GLN A . n 
A 1 518 ASP 518 518 518 ASP ASP A . n 
A 1 519 LEU 519 519 519 LEU LEU A . n 
A 1 520 GLU 520 520 520 GLU GLU A . n 
A 1 521 SER 521 521 521 SER SER A . n 
A 1 522 ARG 522 522 522 ARG ARG A . n 
A 1 523 LYS 523 523 ?   ?   ?   A . n 
A 1 524 GLY 524 524 ?   ?   ?   A . n 
A 1 525 LYS 525 525 ?   ?   ?   A . n 
A 1 526 GLN 526 526 ?   ?   ?   A . n 
A 1 527 THR 527 527 ?   ?   ?   A . n 
A 1 528 ARG 528 528 ?   ?   ?   A . n 
A 1 529 GLN 529 529 ?   ?   ?   A . n 
A 1 530 GLN 530 530 ?   ?   ?   A . n 
A 1 531 GLN 531 531 ?   ?   ?   A . n 
A 1 532 GLU 532 532 ?   ?   ?   A . n 
A 1 533 HIS 533 533 ?   ?   ?   A . n 
A 1 534 GLN 534 534 ?   ?   ?   A . n 
A 1 535 LYS 535 535 ?   ?   ?   A . n 
A 1 536 TYR 536 536 ?   ?   ?   A . n 
A 1 537 MET 537 537 ?   ?   ?   A . n 
A 1 538 VAL 538 538 ?   ?   ?   A . n 
A 1 539 PRO 539 539 ?   ?   ?   A . n 
A 1 540 LEU 540 540 ?   ?   ?   A . n 
A 1 541 GLN 541 541 ?   ?   ?   A . n 
A 1 542 ALA 542 542 ?   ?   ?   A . n 
A 1 543 SER 543 543 ?   ?   ?   A . n 
A 1 544 ALA 544 544 ?   ?   ?   A . n 
A 1 545 GLN 545 545 ?   ?   ?   A . n 
A 1 546 GLU 546 546 ?   ?   ?   A . n 
A 1 547 LYS 547 547 ?   ?   ?   A . n 
A 1 548 ASN 548 548 ?   ?   ?   A . n 
A 1 549 GLY 549 549 ?   ?   ?   A . n 
A 1 550 LEU 550 550 ?   ?   ?   A . n 
A 1 551 HIS 551 551 ?   ?   ?   A . n 
A 1 552 HIS 552 552 ?   ?   ?   A . n 
A 1 553 HIS 553 553 ?   ?   ?   A . n 
A 1 554 HIS 554 554 ?   ?   ?   A . n 
A 1 555 HIS 555 555 ?   ?   ?   A . n 
A 1 556 HIS 556 556 ?   ?   ?   A . n 
A 1 557 HIS 557 557 ?   ?   ?   A . n 
A 1 558 HIS 558 558 ?   ?   ?   A . n 
A 1 559 HIS 559 559 ?   ?   ?   A . n 
A 1 560 HIS 560 560 ?   ?   ?   A . n 
A 1 561 GLY 561 561 ?   ?   ?   A . n 
A 1 562 SER 562 562 ?   ?   ?   A . n 
A 1 563 VAL 563 563 ?   ?   ?   A . n 
A 1 564 GLU 564 564 ?   ?   ?   A . n 
A 1 565 ASP 565 565 ?   ?   ?   A . n 
A 1 566 TYR 566 566 ?   ?   ?   A . n 
A 1 567 LYS 567 567 ?   ?   ?   A . n 
A 1 568 ASP 568 568 ?   ?   ?   A . n 
A 1 569 ASP 569 569 ?   ?   ?   A . n 
A 1 570 ASP 570 570 ?   ?   ?   A . n 
A 1 571 ASP 571 571 ?   ?   ?   A . n 
A 1 572 LYS 572 572 ?   ?   ?   A . n 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A ASN 56 ? CG  ? A ASN 56 CG  
2  1 Y 1 A ASN 56 ? OD1 ? A ASN 56 OD1 
3  1 Y 1 A ASN 56 ? ND2 ? A ASN 56 ND2 
4  1 Y 1 A LEU 57 ? CG  ? A LEU 57 CG  
5  1 Y 1 A LEU 57 ? CD1 ? A LEU 57 CD1 
6  1 Y 1 A LEU 57 ? CD2 ? A LEU 57 CD2 
7  1 Y 1 A SER 58 ? OG  ? A SER 58 OG  
8  1 Y 1 A LYS 59 ? CG  ? A LYS 59 CG  
9  1 Y 1 A LYS 59 ? CD  ? A LYS 59 CD  
10 1 Y 1 A LYS 59 ? CE  ? A LYS 59 CE  
11 1 Y 1 A LYS 59 ? NZ  ? A LYS 59 NZ  
12 1 Y 1 A ASN 60 ? CG  ? A ASN 60 CG  
13 1 Y 1 A ASN 60 ? OD1 ? A ASN 60 OD1 
14 1 Y 1 A ASN 60 ? ND2 ? A ASN 60 ND2 
15 1 Y 1 A GLU 64 ? CG  ? A GLU 64 CG  
16 1 Y 1 A GLU 64 ? CD  ? A GLU 64 CD  
17 1 Y 1 A GLU 64 ? OE1 ? A GLU 64 OE1 
18 1 Y 1 A GLU 64 ? OE2 ? A GLU 64 OE2 
19 1 Y 1 A ARG 69 ? CG  ? A ARG 69 CG  
20 1 Y 1 A ARG 69 ? CD  ? A ARG 69 CD  
21 1 Y 1 A ARG 69 ? NE  ? A ARG 69 NE  
22 1 Y 1 A ARG 69 ? CZ  ? A ARG 69 CZ  
23 1 Y 1 A ARG 69 ? NH1 ? A ARG 69 NH1 
24 1 Y 1 A ARG 69 ? NH2 ? A ARG 69 NH2 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9MAU 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9MAU 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9MAU 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     9MAU 
_struct.title                        'Cryo-EM structure of human OAT1 in the apo state' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9MAU 
_struct_keywords.text            'transporter, OAT1, organic anion transporter, MEMBRANE PROTEIN' 
_struct_keywords.pdbx_keywords   'MEMBRANE PROTEIN' 
# 
_struct_asym.id                            A 
_struct_asym.pdbx_blank_PDB_chainid_flag   N 
_struct_asym.pdbx_modified                 N 
_struct_asym.entity_id                     1 
_struct_asym.details                       ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    S22A6_HUMAN 
_struct_ref.pdbx_db_accession          Q4U2R8 
_struct_ref.pdbx_db_isoform            Q4U2R8-2 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEVWLPRDRQGQPESCLR
FTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLG
RRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV
AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMG
KGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMA
ALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAE
LYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRKGKQTRQQQEHQKYMVPLQASAQEKNGL
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9MAU 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 550 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q4U2R8 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  550 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       550 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9MAU HIS A 551 ? UNP Q4U2R8 ? ? 'expression tag' 551 1  
1 9MAU HIS A 552 ? UNP Q4U2R8 ? ? 'expression tag' 552 2  
1 9MAU HIS A 553 ? UNP Q4U2R8 ? ? 'expression tag' 553 3  
1 9MAU HIS A 554 ? UNP Q4U2R8 ? ? 'expression tag' 554 4  
1 9MAU HIS A 555 ? UNP Q4U2R8 ? ? 'expression tag' 555 5  
1 9MAU HIS A 556 ? UNP Q4U2R8 ? ? 'expression tag' 556 6  
1 9MAU HIS A 557 ? UNP Q4U2R8 ? ? 'expression tag' 557 7  
1 9MAU HIS A 558 ? UNP Q4U2R8 ? ? 'expression tag' 558 8  
1 9MAU HIS A 559 ? UNP Q4U2R8 ? ? 'expression tag' 559 9  
1 9MAU HIS A 560 ? UNP Q4U2R8 ? ? 'expression tag' 560 10 
1 9MAU GLY A 561 ? UNP Q4U2R8 ? ? 'expression tag' 561 11 
1 9MAU SER A 562 ? UNP Q4U2R8 ? ? 'expression tag' 562 12 
1 9MAU VAL A 563 ? UNP Q4U2R8 ? ? 'expression tag' 563 13 
1 9MAU GLU A 564 ? UNP Q4U2R8 ? ? 'expression tag' 564 14 
1 9MAU ASP A 565 ? UNP Q4U2R8 ? ? 'expression tag' 565 15 
1 9MAU TYR A 566 ? UNP Q4U2R8 ? ? 'expression tag' 566 16 
1 9MAU LYS A 567 ? UNP Q4U2R8 ? ? 'expression tag' 567 17 
1 9MAU ASP A 568 ? UNP Q4U2R8 ? ? 'expression tag' 568 18 
1 9MAU ASP A 569 ? UNP Q4U2R8 ? ? 'expression tag' 569 19 
1 9MAU ASP A 570 ? UNP Q4U2R8 ? ? 'expression tag' 570 20 
1 9MAU ASP A 571 ? UNP Q4U2R8 ? ? 'expression tag' 571 21 
1 9MAU LYS A 572 ? UNP Q4U2R8 ? ? 'expression tag' 572 22 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ALA A 2   ? VAL A 10  ? ALA A 2   VAL A 10  1 ? 9  
HELX_P HELX_P2  AA2 GLY A 14  ? LEU A 26  ? GLY A 14  LEU A 26  1 ? 13 
HELX_P HELX_P3  AA3 LEU A 28  ? THR A 36  ? LEU A 28  THR A 36  1 ? 9  
HELX_P HELX_P4  AA4 LEU A 37  ? PHE A 40  ? LEU A 37  PHE A 40  5 ? 4  
HELX_P HELX_P5  AA5 ASN A 56  ? GLY A 61  ? ASN A 56  GLY A 61  1 ? 6  
HELX_P HELX_P6  AA6 GLY A 62  ? LEU A 67  ? GLY A 62  LEU A 67  1 ? 6  
HELX_P HELX_P7  AA7 THR A 119 ? TRP A 124 ? THR A 119 TRP A 124 1 ? 6  
HELX_P HELX_P8  AA8 VAL A 127 ? HIS A 130 ? VAL A 127 HIS A 130 5 ? 4  
HELX_P HELX_P9  AA9 ARG A 131 ? GLY A 160 ? ARG A 131 GLY A 160 1 ? 30 
HELX_P HELX_P10 AB1 GLY A 160 ? PHE A 181 ? GLY A 160 PHE A 181 1 ? 22 
HELX_P HELX_P11 AB2 ASN A 184 ? TRP A 213 ? ASN A 184 TRP A 213 1 ? 30 
HELX_P HELX_P12 AB3 PRO A 215 ? HIS A 217 ? PRO A 215 HIS A 217 5 ? 3  
HELX_P HELX_P13 AB4 THR A 218 ? VAL A 244 ? THR A 218 VAL A 244 1 ? 27 
HELX_P HELX_P14 AB5 HIS A 246 ? ALA A 256 ? HIS A 246 ALA A 256 1 ? 11 
HELX_P HELX_P15 AB6 ALA A 256 ? SER A 265 ? ALA A 256 SER A 265 1 ? 10 
HELX_P HELX_P16 AB7 TRP A 266 ? PHE A 268 ? TRP A 266 PHE A 268 5 ? 3  
HELX_P HELX_P17 AB8 SER A 271 ? GLY A 279 ? SER A 271 GLY A 279 1 ? 9  
HELX_P HELX_P18 AB9 ARG A 280 ? GLY A 296 ? ARG A 280 GLY A 296 1 ? 17 
HELX_P HELX_P19 AC1 LYS A 297 ? LEU A 304 ? LYS A 297 LEU A 304 1 ? 8  
HELX_P HELX_P20 AC2 SER A 305 ? SER A 312 ? SER A 305 SER A 312 1 ? 8  
HELX_P HELX_P21 AC3 SER A 325 ? CYS A 332 ? SER A 325 CYS A 332 1 ? 8  
HELX_P HELX_P22 AC4 CYS A 332 ? MET A 358 ? CYS A 332 MET A 358 1 ? 27 
HELX_P HELX_P23 AC5 SER A 366 ? GLY A 393 ? SER A 366 GLY A 393 1 ? 28 
HELX_P HELX_P24 AC6 GLY A 393 ? ILE A 415 ? GLY A 393 ILE A 415 1 ? 23 
HELX_P HELX_P25 AC7 GLN A 419 ? TYR A 449 ? GLN A 419 TYR A 449 1 ? 31 
HELX_P HELX_P26 AC8 PRO A 450 ? MET A 452 ? PRO A 450 MET A 452 5 ? 3  
HELX_P HELX_P27 AC9 ILE A 453 ? MET A 477 ? ILE A 453 MET A 477 1 ? 25 
HELX_P HELX_P28 AD1 THR A 478 ? GLU A 480 ? THR A 478 GLU A 480 5 ? 3  
HELX_P HELX_P29 AD2 SER A 484 ? THR A 501 ? SER A 484 THR A 501 1 ? 18 
HELX_P HELX_P30 AD3 THR A 515 ? ARG A 522 ? THR A 515 ARG A 522 1 ? 8  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 49 SG ? ? ? 1_555 A CYS 105 SG ? ? A CYS 49 A CYS 105 1_555 ? ? ? ? ? ? ? 2.007 ? ? 
disulf2 disulf ? ? A CYS 78 SG ? ? ? 1_555 A CYS 128 SG ? ? A CYS 78 A CYS 128 1_555 ? ? ? ? ? ? ? 2.030 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 49 ? CYS A 105 ? CYS A 49 ? 1_555 CYS A 105 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 78 ? CYS A 128 ? CYS A 78 ? 1_555 CYS A 128 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 HIS A 47  ? CYS A 49  ? HIS A 47  CYS A 49  
AA1 2 TRP A 109 ? TYR A 111 ? TRP A 109 TYR A 111 
AA2 1 ARG A 80  ? PHE A 81  ? ARG A 80  PHE A 81  
AA2 2 THR A 102 ? GLU A 103 ? THR A 102 GLU A 103 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N HIS A 48 ? N HIS A 48 O ILE A 110 ? O ILE A 110 
AA2 1 2 N ARG A 80 ? N ARG A 80 O GLU A 103 ? O GLU A 103 
# 
_pdbx_entry_details.entry_id                   9MAU 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ALA A 2   ? ? -147.63 14.72   
2 1 CYS A 128 ? ? 59.35   -121.66 
3 1 SER A 305 ? ? -127.76 -166.55 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9MAU 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9MAU 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  2.87 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               205045 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.4 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 OAT1 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        9MAU 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             900 
_em_imaging.nominal_defocus_max             1600 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           130000 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
_em_imaging.objective_aperture              ? 
_em_imaging.microscope_serial_number        ? 
_em_imaging.microscope_version              ? 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    GOLD 
_em_sample_support.grid_mesh_size   300 
_em_sample_support.grid_type        'Quantifoil R1.2/1.3' 
_em_sample_support.details          ? 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_vitrification.entry_id              9MAU 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   281 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9MAU 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A LEU 88  ? A LEU 88  
2  1 Y 1 A PRO 89  ? A PRO 89  
3  1 Y 1 A PHE 90  ? A PHE 90  
4  1 Y 1 A LEU 91  ? A LEU 91  
5  1 Y 1 A ASN 92  ? A ASN 92  
6  1 Y 1 A GLY 93  ? A GLY 93  
7  1 Y 1 A THR 94  ? A THR 94  
8  1 Y 1 A GLU 95  ? A GLU 95  
9  1 Y 1 A ALA 96  ? A ALA 96  
10 1 Y 1 A ASN 97  ? A ASN 97  
11 1 Y 1 A GLY 98  ? A GLY 98  
12 1 Y 1 A THR 318 ? A THR 318 
13 1 Y 1 A MET 319 ? A MET 319 
14 1 Y 1 A GLY 320 ? A GLY 320 
15 1 Y 1 A LYS 321 ? A LYS 321 
16 1 Y 1 A GLY 322 ? A GLY 322 
17 1 Y 1 A LYS 523 ? A LYS 523 
18 1 Y 1 A GLY 524 ? A GLY 524 
19 1 Y 1 A LYS 525 ? A LYS 525 
20 1 Y 1 A GLN 526 ? A GLN 526 
21 1 Y 1 A THR 527 ? A THR 527 
22 1 Y 1 A ARG 528 ? A ARG 528 
23 1 Y 1 A GLN 529 ? A GLN 529 
24 1 Y 1 A GLN 530 ? A GLN 530 
25 1 Y 1 A GLN 531 ? A GLN 531 
26 1 Y 1 A GLU 532 ? A GLU 532 
27 1 Y 1 A HIS 533 ? A HIS 533 
28 1 Y 1 A GLN 534 ? A GLN 534 
29 1 Y 1 A LYS 535 ? A LYS 535 
30 1 Y 1 A TYR 536 ? A TYR 536 
31 1 Y 1 A MET 537 ? A MET 537 
32 1 Y 1 A VAL 538 ? A VAL 538 
33 1 Y 1 A PRO 539 ? A PRO 539 
34 1 Y 1 A LEU 540 ? A LEU 540 
35 1 Y 1 A GLN 541 ? A GLN 541 
36 1 Y 1 A ALA 542 ? A ALA 542 
37 1 Y 1 A SER 543 ? A SER 543 
38 1 Y 1 A ALA 544 ? A ALA 544 
39 1 Y 1 A GLN 545 ? A GLN 545 
40 1 Y 1 A GLU 546 ? A GLU 546 
41 1 Y 1 A LYS 547 ? A LYS 547 
42 1 Y 1 A ASN 548 ? A ASN 548 
43 1 Y 1 A GLY 549 ? A GLY 549 
44 1 Y 1 A LEU 550 ? A LEU 550 
45 1 Y 1 A HIS 551 ? A HIS 551 
46 1 Y 1 A HIS 552 ? A HIS 552 
47 1 Y 1 A HIS 553 ? A HIS 553 
48 1 Y 1 A HIS 554 ? A HIS 554 
49 1 Y 1 A HIS 555 ? A HIS 555 
50 1 Y 1 A HIS 556 ? A HIS 556 
51 1 Y 1 A HIS 557 ? A HIS 557 
52 1 Y 1 A HIS 558 ? A HIS 558 
53 1 Y 1 A HIS 559 ? A HIS 559 
54 1 Y 1 A HIS 560 ? A HIS 560 
55 1 Y 1 A GLY 561 ? A GLY 561 
56 1 Y 1 A SER 562 ? A SER 562 
57 1 Y 1 A VAL 563 ? A VAL 563 
58 1 Y 1 A GLU 564 ? A GLU 564 
59 1 Y 1 A ASP 565 ? A ASP 565 
60 1 Y 1 A TYR 566 ? A TYR 566 
61 1 Y 1 A LYS 567 ? A LYS 567 
62 1 Y 1 A ASP 568 ? A ASP 568 
63 1 Y 1 A ASP 569 ? A ASP 569 
64 1 Y 1 A ASP 570 ? A ASP 570 
65 1 Y 1 A ASP 571 ? A ASP 571 
66 1 Y 1 A LYS 572 ? A LYS 572 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2025-03-14 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           9MAU 
_em_admin.last_update        2025-06-18 
_em_admin.map_release_date   2025-06-18 
_em_admin.title              'Cryo-EM structure of human OAT1 in the apo state' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     NONE 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                ? 
_em_entity_assembly_molwt.value                ? 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         49.6 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'TFS FALCON 4i (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
_em_software.reference_DOI 
'PARTICLE SELECTION'            ? 1  1 ? ? ? ? ? 
'IMAGE ACQUISITION'             ? 2  ? ? 1 ? ? ? 
MASKING                         ? 3  ? ? ? ? ? ? 
'CTF CORRECTION'                ? 4  1 ? ? ? ? ? 
'LAYERLINE INDEXING'            ? 5  ? ? ? ? ? ? 
'DIFFRACTION INDEXING'          ? 6  ? ? ? ? ? ? 
'MODEL FITTING'                 ? 7  ? ? ? ? ? ? 
'MODEL REFINEMENT'              ? 8  ? ? ? ? ? ? 
OTHER                           ? 9  ? ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ? ? ? 
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ? ? ? 
CLASSIFICATION                  ? 12 1 ? ? ? ? ? 
RECONSTRUCTION                  ? 13 1 ? ? ? ? ? 
'VOLUME SELECTION'              ? 14 1 1 1 ? ? ? 
'SERIES ALIGNMENT'              ? 15 1 1 1 ? ? ? 
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ? ? ? 
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ? ? ? 
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ? ? ? 
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ? ? ? 
# 
_em_specimen.concentration           5 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    9MAU 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . MET A 1 1   ? 141.300 108.776 100.897 1.00 0.00   ?  1   MET A N   1 
ATOM 2    C CA  . MET A 1 1   ? 140.442 109.835 101.416 1.00 0.00   ?  1   MET A CA  1 
ATOM 3    C C   . MET A 1 1   ? 140.511 111.078 100.540 1.00 0.00   ?  1   MET A C   1 
ATOM 4    O O   . MET A 1 1   ? 140.939 112.139 100.993 1.00 0.00   ?  1   MET A O   1 
ATOM 5    C CB  . MET A 1 1   ? 140.834 110.188 102.852 1.00 0.00   ?  1   MET A CB  1 
ATOM 6    C CG  . MET A 1 1   ? 140.730 109.029 103.827 1.00 0.00   ?  1   MET A CG  1 
ATOM 7    S SD  . MET A 1 1   ? 141.109 109.524 105.517 1.00 0.00   ?  1   MET A SD  1 
ATOM 8    C CE  . MET A 1 1   ? 140.927 107.962 106.373 1.00 0.00   ?  1   MET A CE  1 
ATOM 9    N N   . ALA A 1 2   ? 140.097 110.950 99.284  1.00 145.62 ?  2   ALA A N   1 
ATOM 10   C CA  . ALA A 1 2   ? 140.168 112.086 98.377  1.00 146.15 ?  2   ALA A CA  1 
ATOM 11   C C   . ALA A 1 2   ? 139.056 112.101 97.349  1.00 144.78 ?  2   ALA A C   1 
ATOM 12   O O   . ALA A 1 2   ? 139.136 112.832 96.370  1.00 142.51 ?  2   ALA A O   1 
ATOM 13   C CB  . ALA A 1 2   ? 141.521 112.123 97.690  1.00 142.76 ?  2   ALA A CB  1 
ATOM 14   N N   . PHE A 1 3   ? 138.016 111.308 97.555  1.00 139.73 ?  3   PHE A N   1 
ATOM 15   C CA  . PHE A 1 3   ? 136.892 111.376 96.643  1.00 139.07 ?  3   PHE A CA  1 
ATOM 16   C C   . PHE A 1 3   ? 136.294 112.757 96.780  1.00 136.41 ?  3   PHE A C   1 
ATOM 17   O O   . PHE A 1 3   ? 135.911 113.377 95.795  1.00 138.13 ?  3   PHE A O   1 
ATOM 18   C CB  . PHE A 1 3   ? 135.842 110.316 96.943  1.00 139.55 ?  3   PHE A CB  1 
ATOM 19   C CG  . PHE A 1 3   ? 134.695 110.316 95.973  1.00 137.33 ?  3   PHE A CG  1 
ATOM 20   C CD1 . PHE A 1 3   ? 134.776 109.607 94.789  1.00 136.57 ?  3   PHE A CD1 1 
ATOM 21   C CD2 . PHE A 1 3   ? 133.543 111.034 96.239  1.00 136.62 ?  3   PHE A CD2 1 
ATOM 22   C CE1 . PHE A 1 3   ? 133.728 109.610 93.890  1.00 136.67 ?  3   PHE A CE1 1 
ATOM 23   C CE2 . PHE A 1 3   ? 132.491 111.042 95.345  1.00 135.43 ?  3   PHE A CE2 1 
ATOM 24   C CZ  . PHE A 1 3   ? 132.583 110.328 94.169  1.00 135.04 ?  3   PHE A CZ  1 
ATOM 25   N N   . ASN A 1 4   ? 136.222 113.249 98.006  1.00 135.61 ?  4   ASN A N   1 
ATOM 26   C CA  . ASN A 1 4   ? 135.700 114.581 98.218  1.00 135.62 ?  4   ASN A CA  1 
ATOM 27   C C   . ASN A 1 4   ? 136.668 115.588 97.649  1.00 136.71 ?  4   ASN A C   1 
ATOM 28   O O   . ASN A 1 4   ? 136.410 116.786 97.697  1.00 141.37 ?  4   ASN A O   1 
ATOM 29   C CB  . ASN A 1 4   ? 135.463 114.851 99.699  1.00 136.04 ?  4   ASN A CB  1 
ATOM 30   C CG  . ASN A 1 4   ? 134.764 116.170 99.946  1.00 138.28 ?  4   ASN A CG  1 
ATOM 31   O OD1 . ASN A 1 4   ? 134.868 116.745 101.028 1.00 138.12 ?  4   ASN A OD1 1 
ATOM 32   N ND2 . ASN A 1 4   ? 134.053 116.662 98.940  1.00 140.49 ?  4   ASN A ND2 1 
ATOM 33   N N   . ASP A 1 5   ? 137.794 115.127 97.107  1.00 136.80 ?  5   ASP A N   1 
ATOM 34   C CA  . ASP A 1 5   ? 138.668 116.089 96.462  1.00 137.95 ?  5   ASP A CA  1 
ATOM 35   C C   . ASP A 1 5   ? 138.336 116.012 95.000  1.00 141.40 ?  5   ASP A C   1 
ATOM 36   O O   . ASP A 1 5   ? 138.496 116.983 94.266  1.00 144.28 ?  5   ASP A O   1 
ATOM 37   C CB  . ASP A 1 5   ? 140.129 115.740 96.697  1.00 138.44 ?  5   ASP A CB  1 
ATOM 38   C CG  . ASP A 1 5   ? 140.505 115.769 98.162  1.00 142.81 ?  5   ASP A CG  1 
ATOM 39   O OD1 . ASP A 1 5   ? 139.629 116.070 98.999  1.00 141.88 ?  5   ASP A OD1 1 
ATOM 40   O OD2 . ASP A 1 5   ? 141.681 115.496 98.478  1.00 142.51 -1 5   ASP A OD2 1 
ATOM 41   N N   . LEU A 1 6   ? 137.862 114.852 94.571  1.00 135.14 ?  6   LEU A N   1 
ATOM 42   C CA  . LEU A 1 6   ? 137.472 114.664 93.171  1.00 133.17 ?  6   LEU A CA  1 
ATOM 43   C C   . LEU A 1 6   ? 136.082 115.202 92.874  1.00 129.64 ?  6   LEU A C   1 
ATOM 44   O O   . LEU A 1 6   ? 135.845 115.725 91.793  1.00 130.21 ?  6   LEU A O   1 
ATOM 45   C CB  . LEU A 1 6   ? 137.581 113.200 92.758  1.00 129.72 ?  6   LEU A CB  1 
ATOM 46   C CG  . LEU A 1 6   ? 138.998 112.645 92.831  1.00 131.83 ?  6   LEU A CG  1 
ATOM 47   C CD1 . LEU A 1 6   ? 138.996 111.155 92.561  1.00 134.85 ?  6   LEU A CD1 1 
ATOM 48   C CD2 . LEU A 1 6   ? 139.914 113.375 91.863  1.00 130.59 ?  6   LEU A CD2 1 
ATOM 49   N N   . LEU A 1 7   ? 135.143 115.038 93.799  1.00 117.60 ?  7   LEU A N   1 
ATOM 50   C CA  . LEU A 1 7   ? 133.792 115.521 93.584  1.00 114.33 ?  7   LEU A CA  1 
ATOM 51   C C   . LEU A 1 7   ? 133.870 117.010 93.437  1.00 117.46 ?  7   LEU A C   1 
ATOM 52   O O   . LEU A 1 7   ? 133.238 117.573 92.559  1.00 120.82 ?  7   LEU A O   1 
ATOM 53   C CB  . LEU A 1 7   ? 132.880 115.147 94.748  1.00 114.59 ?  7   LEU A CB  1 
ATOM 54   C CG  . LEU A 1 7   ? 131.405 115.493 94.639  1.00 112.81 ?  7   LEU A CG  1 
ATOM 55   C CD1 . LEU A 1 7   ? 130.791 114.886 93.390  1.00 115.79 ?  7   LEU A CD1 1 
ATOM 56   C CD2 . LEU A 1 7   ? 130.693 114.995 95.879  1.00 118.38 ?  7   LEU A CD2 1 
ATOM 57   N N   . GLN A 1 8   ? 134.678 117.664 94.273  1.00 128.72 ?  8   GLN A N   1 
ATOM 58   C CA  . GLN A 1 8   ? 134.841 119.114 94.194  1.00 130.10 ?  8   GLN A CA  1 
ATOM 59   C C   . GLN A 1 8   ? 135.575 119.554 92.938  1.00 130.87 ?  8   GLN A C   1 
ATOM 60   O O   . GLN A 1 8   ? 135.304 120.635 92.425  1.00 132.01 ?  8   GLN A O   1 
ATOM 61   C CB  . GLN A 1 8   ? 135.534 119.674 95.432  1.00 129.05 ?  8   GLN A CB  1 
ATOM 62   C CG  . GLN A 1 8   ? 134.677 119.637 96.692  1.00 127.08 ?  8   GLN A CG  1 
ATOM 63   C CD  . GLN A 1 8   ? 135.345 120.302 97.883  1.00 132.11 ?  8   GLN A CD  1 
ATOM 64   O OE1 . GLN A 1 8   ? 136.390 120.940 97.754  1.00 133.76 ?  8   GLN A OE1 1 
ATOM 65   N NE2 . GLN A 1 8   ? 134.739 120.158 99.053  1.00 133.16 ?  8   GLN A NE2 1 
ATOM 66   N N   . GLN A 1 9   ? 136.502 118.743 92.439  1.00 129.92 ?  9   GLN A N   1 
ATOM 67   C CA  . GLN A 1 9   ? 137.181 119.064 91.182  1.00 127.87 ?  9   GLN A CA  1 
ATOM 68   C C   . GLN A 1 9   ? 136.138 119.086 90.106  1.00 132.25 ?  9   GLN A C   1 
ATOM 69   O O   . GLN A 1 9   ? 136.169 119.957 89.241  1.00 134.07 ?  9   GLN A O   1 
ATOM 70   C CB  . GLN A 1 9   ? 138.243 118.016 90.831  1.00 128.56 ?  9   GLN A CB  1 
ATOM 71   C CG  . GLN A 1 9   ? 138.933 118.234 89.484  1.00 131.84 ?  9   GLN A CG  1 
ATOM 72   C CD  . GLN A 1 9   ? 139.868 117.101 89.099  1.00 135.36 ?  9   GLN A CD  1 
ATOM 73   O OE1 . GLN A 1 9   ? 140.184 116.232 89.911  1.00 135.91 ?  9   GLN A OE1 1 
ATOM 74   N NE2 . GLN A 1 9   ? 140.314 117.105 87.846  1.00 132.79 ?  9   GLN A NE2 1 
ATOM 75   N N   . VAL A 1 10  ? 135.213 118.135 90.155  1.00 130.10 ?  10  VAL A N   1 
ATOM 76   C CA  . VAL A 1 10  ? 134.147 118.038 89.162  1.00 126.62 ?  10  VAL A CA  1 
ATOM 77   C C   . VAL A 1 10  ? 132.959 118.871 89.649  1.00 125.23 ?  10  VAL A C   1 
ATOM 78   O O   . VAL A 1 10  ? 131.939 118.317 90.033  1.00 129.83 ?  10  VAL A O   1 
ATOM 79   C CB  . VAL A 1 10  ? 133.787 116.552 88.900  1.00 124.27 ?  10  VAL A CB  1 
ATOM 80   C CG1 . VAL A 1 10  ? 132.589 116.411 87.988  1.00 122.83 ?  10  VAL A CG1 1 
ATOM 81   C CG2 . VAL A 1 10  ? 134.978 115.800 88.312  1.00 121.85 ?  10  VAL A CG2 1 
ATOM 82   N N   . GLY A 1 11  ? 133.114 120.189 89.751  1.00 124.01 ?  11  GLY A N   1 
ATOM 83   C CA  . GLY A 1 11  ? 132.001 121.071 90.090  1.00 123.70 ?  11  GLY A CA  1 
ATOM 84   C C   . GLY A 1 11  ? 131.446 121.197 91.494  1.00 122.96 ?  11  GLY A C   1 
ATOM 85   O O   . GLY A 1 11  ? 130.679 122.122 91.735  1.00 125.25 ?  11  GLY A O   1 
ATOM 86   N N   . GLY A 1 12  ? 131.826 120.336 92.428  1.00 120.99 ?  12  GLY A N   1 
ATOM 87   C CA  . GLY A 1 12  ? 131.230 120.362 93.753  1.00 122.68 ?  12  GLY A CA  1 
ATOM 88   C C   . GLY A 1 12  ? 129.729 120.282 93.628  1.00 124.81 ?  12  GLY A C   1 
ATOM 89   O O   . GLY A 1 12  ? 129.261 119.322 93.032  1.00 126.12 ?  12  GLY A O   1 
ATOM 90   N N   . VAL A 1 13  ? 128.975 121.244 94.176  1.00 126.55 ?  13  VAL A N   1 
ATOM 91   C CA  . VAL A 1 13  ? 127.524 121.275 93.976  1.00 124.93 ?  13  VAL A CA  1 
ATOM 92   C C   . VAL A 1 13  ? 127.365 122.073 92.693  1.00 122.91 ?  13  VAL A C   1 
ATOM 93   O O   . VAL A 1 13  ? 127.867 123.191 92.612  1.00 124.05 ?  13  VAL A O   1 
ATOM 94   C CB  . VAL A 1 13  ? 126.759 121.934 95.136  1.00 127.17 ?  13  VAL A CB  1 
ATOM 95   C CG1 . VAL A 1 13  ? 125.263 121.696 94.974  1.00 121.00 ?  13  VAL A CG1 1 
ATOM 96   C CG2 . VAL A 1 13  ? 127.239 121.390 96.474  1.00 124.82 ?  13  VAL A CG2 1 
ATOM 97   N N   . GLY A 1 14  ? 126.710 121.521 91.676  1.00 116.05 ?  14  GLY A N   1 
ATOM 98   C CA  . GLY A 1 14  ? 126.582 122.194 90.399  1.00 116.64 ?  14  GLY A CA  1 
ATOM 99   C C   . GLY A 1 14  ? 125.348 121.641 89.754  1.00 118.00 ?  14  GLY A C   1 
ATOM 100  O O   . GLY A 1 14  ? 124.587 120.979 90.428  1.00 117.73 ?  14  GLY A O   1 
ATOM 101  N N   . ARG A 1 15  ? 125.144 121.862 88.457  1.00 123.69 ?  15  ARG A N   1 
ATOM 102  C CA  . ARG A 1 15  ? 123.901 121.437 87.830  1.00 119.67 ?  15  ARG A CA  1 
ATOM 103  C C   . ARG A 1 15  ? 123.522 120.021 88.172  1.00 115.33 ?  15  ARG A C   1 
ATOM 104  O O   . ARG A 1 15  ? 122.396 119.796 88.513  1.00 117.65 ?  15  ARG A O   1 
ATOM 105  C CB  . ARG A 1 15  ? 123.914 121.626 86.313  1.00 116.12 ?  15  ARG A CB  1 
ATOM 106  C CG  . ARG A 1 15  ? 123.758 123.074 85.870  1.00 113.19 ?  15  ARG A CG  1 
ATOM 107  C CD  . ARG A 1 15  ? 123.480 123.207 84.380  1.00 119.27 ?  15  ARG A CD  1 
ATOM 108  N NE  . ARG A 1 15  ? 124.624 122.835 83.544  1.00 126.81 ?  15  ARG A NE  1 
ATOM 109  C CZ  . ARG A 1 15  ? 125.678 123.612 83.261  1.00 125.76 ?  15  ARG A CZ  1 
ATOM 110  N NH1 . ARG A 1 15  ? 125.802 124.847 83.760  1.00 123.42 1  15  ARG A NH1 1 
ATOM 111  N NH2 . ARG A 1 15  ? 126.643 123.137 82.471  1.00 119.67 ?  15  ARG A NH2 1 
ATOM 112  N N   . PHE A 1 16  ? 124.428 119.063 88.093  1.00 100.53 ?  16  PHE A N   1 
ATOM 113  C CA  . PHE A 1 16  ? 124.034 117.678 88.330  1.00 101.02 ?  16  PHE A CA  1 
ATOM 114  C C   . PHE A 1 16  ? 123.471 117.459 89.730  1.00 103.20 ?  16  PHE A C   1 
ATOM 115  O O   . PHE A 1 16  ? 122.494 116.767 89.868  1.00 111.45 ?  16  PHE A O   1 
ATOM 116  C CB  . PHE A 1 16  ? 125.180 116.710 88.082  1.00 99.70  ?  16  PHE A CB  1 
ATOM 117  C CG  . PHE A 1 16  ? 124.972 115.369 88.696  1.00 102.56 ?  16  PHE A CG  1 
ATOM 118  C CD1 . PHE A 1 16  ? 124.087 114.472 88.142  1.00 104.57 ?  16  PHE A CD1 1 
ATOM 119  C CD2 . PHE A 1 16  ? 125.658 115.011 89.837  1.00 103.57 ?  16  PHE A CD2 1 
ATOM 120  C CE1 . PHE A 1 16  ? 123.888 113.242 88.718  1.00 104.74 ?  16  PHE A CE1 1 
ATOM 121  C CE2 . PHE A 1 16  ? 125.466 113.785 90.414  1.00 98.36  ?  16  PHE A CE2 1 
ATOM 122  C CZ  . PHE A 1 16  ? 124.583 112.894 89.855  1.00 102.92 ?  16  PHE A CZ  1 
ATOM 123  N N   . GLN A 1 17  ? 124.097 118.004 90.765  1.00 103.79 ?  17  GLN A N   1 
ATOM 124  C CA  . GLN A 1 17  ? 123.628 117.841 92.125  1.00 99.35  ?  17  GLN A CA  1 
ATOM 125  C C   . GLN A 1 17  ? 122.323 118.582 92.347  1.00 104.71 ?  17  GLN A C   1 
ATOM 126  O O   . GLN A 1 17  ? 121.437 118.073 92.993  1.00 106.07 ?  17  GLN A O   1 
ATOM 127  C CB  . GLN A 1 17  ? 124.691 118.264 93.126  1.00 101.71 ?  17  GLN A CB  1 
ATOM 128  C CG  . GLN A 1 17  ? 125.824 117.268 93.289  1.00 104.28 ?  17  GLN A CG  1 
ATOM 129  C CD  . GLN A 1 17  ? 126.963 117.493 92.319  1.00 106.52 ?  17  GLN A CD  1 
ATOM 130  O OE1 . GLN A 1 17  ? 126.981 118.471 91.578  1.00 108.49 ?  17  GLN A OE1 1 
ATOM 131  N NE2 . GLN A 1 17  ? 127.930 116.589 92.329  1.00 102.26 ?  17  GLN A NE2 1 
ATOM 132  N N   . GLN A 1 18  ? 122.172 119.766 91.779  1.00 107.38 ?  18  GLN A N   1 
ATOM 133  C CA  . GLN A 1 18  ? 120.907 120.478 91.891  1.00 103.31 ?  18  GLN A CA  1 
ATOM 134  C C   . GLN A 1 18  ? 119.770 119.701 91.222  1.00 108.61 ?  18  GLN A C   1 
ATOM 135  O O   . GLN A 1 18  ? 118.738 119.485 91.840  1.00 109.99 ?  18  GLN A O   1 
ATOM 136  C CB  . GLN A 1 18  ? 121.044 121.872 91.302  1.00 95.98  ?  18  GLN A CB  1 
ATOM 137  C CG  . GLN A 1 18  ? 122.157 122.688 91.928  1.00 106.73 ?  18  GLN A CG  1 
ATOM 138  C CD  . GLN A 1 18  ? 122.580 123.851 91.059  1.00 108.53 ?  18  GLN A CD  1 
ATOM 139  O OE1 . GLN A 1 18  ? 121.956 124.134 90.040  1.00 105.83 ?  18  GLN A OE1 1 
ATOM 140  N NE2 . GLN A 1 18  ? 123.646 124.529 91.456  1.00 111.12 ?  18  GLN A NE2 1 
ATOM 141  N N   . ILE A 1 19  ? 119.963 119.234 89.986  1.00 100.57 ?  19  ILE A N   1 
ATOM 142  C CA  . ILE A 1 19  ? 118.931 118.496 89.251  1.00 94.85  ?  19  ILE A CA  1 
ATOM 143  C C   . ILE A 1 19  ? 118.623 117.172 89.923  1.00 93.57  ?  19  ILE A C   1 
ATOM 144  O O   . ILE A 1 19  ? 117.488 116.918 90.267  1.00 102.52 ?  19  ILE A O   1 
ATOM 145  C CB  . ILE A 1 19  ? 119.332 118.243 87.782  1.00 86.93  ?  19  ILE A CB  1 
ATOM 146  C CG1 . ILE A 1 19  ? 119.428 119.563 87.003  1.00 93.44  ?  19  ILE A CG1 1 
ATOM 147  C CG2 . ILE A 1 19  ? 118.334 117.315 87.095  1.00 89.72  ?  19  ILE A CG2 1 
ATOM 148  C CD1 . ILE A 1 19  ? 120.416 119.529 85.854  1.00 96.64  ?  19  ILE A CD1 1 
ATOM 149  N N   . GLN A 1 20  ? 119.623 116.328 90.121  1.00 88.10  ?  20  GLN A N   1 
ATOM 150  C CA  . GLN A 1 20  ? 119.395 115.013 90.710  1.00 89.75  ?  20  GLN A CA  1 
ATOM 151  C C   . GLN A 1 20  ? 118.867 115.076 92.121  1.00 99.84  ?  20  GLN A C   1 
ATOM 152  O O   . GLN A 1 20  ? 118.042 114.279 92.449  1.00 101.45 ?  20  GLN A O   1 
ATOM 153  C CB  . GLN A 1 20  ? 120.637 114.121 90.690  1.00 91.65  ?  20  GLN A CB  1 
ATOM 154  C CG  . GLN A 1 20  ? 120.418 112.762 91.342  1.00 91.45  ?  20  GLN A CG  1 
ATOM 155  C CD  . GLN A 1 20  ? 121.392 111.716 90.861  1.00 101.78 ?  20  GLN A CD  1 
ATOM 156  O OE1 . GLN A 1 20  ? 121.330 111.297 89.714  1.00 101.66 ?  20  GLN A OE1 1 
ATOM 157  N NE2 . GLN A 1 20  ? 122.283 111.274 91.735  1.00 101.18 ?  20  GLN A NE2 1 
ATOM 158  N N   . VAL A 1 21  ? 119.335 115.974 92.973  1.00 102.31 ?  21  VAL A N   1 
ATOM 159  C CA  . VAL A 1 21  ? 118.871 115.960 94.363  1.00 102.06 ?  21  VAL A CA  1 
ATOM 160  C C   . VAL A 1 21  ? 117.413 116.430 94.402  1.00 101.81 ?  21  VAL A C   1 
ATOM 161  O O   . VAL A 1 21  ? 116.630 115.876 95.126  1.00 102.91 ?  21  VAL A O   1 
ATOM 162  C CB  . VAL A 1 21  ? 119.781 116.760 95.320  1.00 103.73 ?  21  VAL A CB  1 
ATOM 163  C CG1 . VAL A 1 21  ? 119.187 116.810 96.723  1.00 107.09 ?  21  VAL A CG1 1 
ATOM 164  C CG2 . VAL A 1 21  ? 121.170 116.129 95.385  1.00 97.07  ?  21  VAL A CG2 1 
ATOM 165  N N   . THR A 1 22  ? 117.043 117.442 93.626  1.00 91.05  ?  22  THR A N   1 
ATOM 166  C CA  . THR A 1 22  ? 115.644 117.853 93.565  1.00 93.29  ?  22  THR A CA  1 
ATOM 167  C C   . THR A 1 22  ? 114.812 116.632 93.223  1.00 98.40  ?  22  THR A C   1 
ATOM 168  O O   . THR A 1 22  ? 113.859 116.324 93.924  1.00 100.73 ?  22  THR A O   1 
ATOM 169  C CB  . THR A 1 22  ? 115.415 118.955 92.507  1.00 88.73  ?  22  THR A CB  1 
ATOM 170  O OG1 . THR A 1 22  ? 115.964 120.195 92.963  1.00 85.09  ?  22  THR A OG1 1 
ATOM 171  C CG2 . THR A 1 22  ? 113.932 119.150 92.225  1.00 95.40  ?  22  THR A CG2 1 
ATOM 172  N N   . LEU A 1 23  ? 115.180 115.922 92.166  1.00 92.22  ?  23  LEU A N   1 
ATOM 173  C CA  . LEU A 1 23  ? 114.427 114.756 91.711  1.00 88.67  ?  23  LEU A CA  1 
ATOM 174  C C   . LEU A 1 23  ? 114.381 113.594 92.681  1.00 94.03  ?  23  LEU A C   1 
ATOM 175  O O   . LEU A 1 23  ? 113.375 112.910 92.742  1.00 98.88  ?  23  LEU A O   1 
ATOM 176  C CB  . LEU A 1 23  ? 114.971 114.269 90.373  1.00 91.68  ?  23  LEU A CB  1 
ATOM 177  C CG  . LEU A 1 23  ? 114.850 115.184 89.149  1.00 88.34  ?  23  LEU A CG  1 
ATOM 178  C CD1 . LEU A 1 23  ? 115.793 114.718 88.051  1.00 89.21  ?  23  LEU A CD1 1 
ATOM 179  C CD2 . LEU A 1 23  ? 113.419 115.256 88.641  1.00 86.64  ?  23  LEU A CD2 1 
ATOM 180  N N   . VAL A 1 24  ? 115.469 113.328 93.391  1.00 95.49  ?  24  VAL A N   1 
ATOM 181  C CA  . VAL A 1 24  ? 115.533 112.193 94.322  1.00 95.85  ?  24  VAL A CA  1 
ATOM 182  C C   . VAL A 1 24  ? 114.806 112.508 95.645  1.00 100.13 ?  24  VAL A C   1 
ATOM 183  O O   . VAL A 1 24  ? 114.328 111.576 96.286  1.00 102.67 ?  24  VAL A O   1 
ATOM 184  C CB  . VAL A 1 24  ? 116.997 111.731 94.551  1.00 91.17  ?  24  VAL A CB  1 
ATOM 185  C CG1 . VAL A 1 24  ? 117.097 110.654 95.613  1.00 93.19  ?  24  VAL A CG1 1 
ATOM 186  C CG2 . VAL A 1 24  ? 117.611 111.191 93.266  1.00 93.63  ?  24  VAL A CG2 1 
ATOM 187  N N   . VAL A 1 25  ? 114.700 113.786 96.045  1.00 98.10  ?  25  VAL A N   1 
ATOM 188  C CA  . VAL A 1 25  ? 113.962 114.177 97.265  1.00 94.18  ?  25  VAL A CA  1 
ATOM 189  C C   . VAL A 1 25  ? 112.474 114.458 97.026  1.00 97.43  ?  25  VAL A C   1 
ATOM 190  O O   . VAL A 1 25  ? 111.686 114.488 97.960  1.00 101.55 ?  25  VAL A O   1 
ATOM 191  C CB  . VAL A 1 25  ? 114.647 115.370 97.976  1.00 95.90  ?  25  VAL A CB  1 
ATOM 192  C CG1 . VAL A 1 25  ? 114.071 115.609 99.357  1.00 104.01 ?  25  VAL A CG1 1 
ATOM 193  C CG2 . VAL A 1 25  ? 116.122 115.083 98.159  1.00 98.40  ?  25  VAL A CG2 1 
ATOM 194  N N   . LEU A 1 26  ? 112.062 114.610 95.776  1.00 94.84  ?  26  LEU A N   1 
ATOM 195  C CA  . LEU A 1 26  ? 110.641 114.804 95.464  1.00 92.61  ?  26  LEU A CA  1 
ATOM 196  C C   . LEU A 1 26  ? 109.753 113.621 95.881  1.00 94.40  ?  26  LEU A C   1 
ATOM 197  O O   . LEU A 1 26  ? 108.636 113.836 96.322  1.00 96.03  ?  26  LEU A O   1 
ATOM 198  C CB  . LEU A 1 26  ? 110.443 115.164 93.990  1.00 88.40  ?  26  LEU A CB  1 
ATOM 199  C CG  . LEU A 1 26  ? 109.221 115.977 93.588  1.00 89.82  ?  26  LEU A CG  1 
ATOM 200  C CD1 . LEU A 1 26  ? 109.393 117.399 94.092  1.00 88.78  ?  26  LEU A CD1 1 
ATOM 201  C CD2 . LEU A 1 26  ? 109.095 115.963 92.075  1.00 93.31  ?  26  LEU A CD2 1 
ATOM 202  N N   . PRO A 1 27  ? 110.219 112.368 95.728  1.00 95.37  ?  27  PRO A N   1 
ATOM 203  C CA  . PRO A 1 27  ? 109.419 111.253 96.234  1.00 90.97  ?  27  PRO A CA  1 
ATOM 204  C C   . PRO A 1 27  ? 109.182 111.321 97.723  1.00 96.83  ?  27  PRO A C   1 
ATOM 205  O O   . PRO A 1 27  ? 108.108 110.941 98.163  1.00 96.27  ?  27  PRO A O   1 
ATOM 206  C CB  . PRO A 1 27  ? 110.312 110.068 95.962  1.00 95.67  ?  27  PRO A CB  1 
ATOM 207  C CG  . PRO A 1 27  ? 110.982 110.415 94.692  1.00 95.94  ?  27  PRO A CG  1 
ATOM 208  C CD  . PRO A 1 27  ? 111.163 111.899 94.699  1.00 93.43  ?  27  PRO A CD  1 
ATOM 209  N N   . LEU A 1 28  ? 110.143 111.816 98.496  1.00 100.45 ?  28  LEU A N   1 
ATOM 210  C CA  . LEU A 1 28  ? 110.023 111.862 99.954  1.00 97.99  ?  28  LEU A CA  1 
ATOM 211  C C   . LEU A 1 28  ? 108.882 112.737 100.430 1.00 97.66  ?  28  LEU A C   1 
ATOM 212  O O   . LEU A 1 28  ? 108.509 112.689 101.597 1.00 104.16 ?  28  LEU A O   1 
ATOM 213  C CB  . LEU A 1 28  ? 111.339 112.293 100.587 1.00 90.10  ?  28  LEU A CB  1 
ATOM 214  C CG  . LEU A 1 28  ? 112.528 111.406 100.237 1.00 97.08  ?  28  LEU A CG  1 
ATOM 215  C CD1 . LEU A 1 28  ? 113.814 112.011 100.764 1.00 97.47  ?  28  LEU A CD1 1 
ATOM 216  C CD2 . LEU A 1 28  ? 112.327 110.004 100.783 1.00 102.60 ?  28  LEU A CD2 1 
ATOM 217  N N   . LEU A 1 29  ? 108.321 113.542 99.544  1.00 80.88  ?  29  LEU A N   1 
ATOM 218  C CA  . LEU A 1 29  ? 107.162 114.345 99.895  1.00 80.35  ?  29  LEU A CA  1 
ATOM 219  C C   . LEU A 1 29  ? 106.010 113.402 100.216 1.00 88.31  ?  29  LEU A C   1 
ATOM 220  O O   . LEU A 1 29  ? 105.216 113.677 101.095 1.00 94.26  ?  29  LEU A O   1 
ATOM 221  C CB  . LEU A 1 29  ? 106.810 115.298 98.761  1.00 81.72  ?  29  LEU A CB  1 
ATOM 222  C CG  . LEU A 1 29  ? 106.123 116.623 99.069  1.00 78.93  ?  29  LEU A CG  1 
ATOM 223  C CD1 . LEU A 1 29  ? 107.010 117.472 99.959  1.00 86.31  ?  29  LEU A CD1 1 
ATOM 224  C CD2 . LEU A 1 29  ? 105.844 117.352 97.767  1.00 81.05  ?  29  LEU A CD2 1 
ATOM 225  N N   . LEU A 1 30  ? 105.902 112.293 99.492  1.00 91.48  ?  30  LEU A N   1 
ATOM 226  C CA  . LEU A 1 30  ? 104.784 111.366 99.675  1.00 90.35  ?  30  LEU A CA  1 
ATOM 227  C C   . LEU A 1 30  ? 105.044 110.202 100.612 1.00 92.28  ?  30  LEU A C   1 
ATOM 228  O O   . LEU A 1 30  ? 104.290 109.249 100.604 1.00 102.80 ?  30  LEU A O   1 
ATOM 229  C CB  . LEU A 1 30  ? 104.350 110.813 98.323  1.00 86.47  ?  30  LEU A CB  1 
ATOM 230  C CG  . LEU A 1 30  ? 103.775 111.756 97.271  1.00 82.19  ?  30  LEU A CG  1 
ATOM 231  C CD1 . LEU A 1 30  ? 103.976 111.158 95.892  1.00 88.50  ?  30  LEU A CD1 1 
ATOM 232  C CD2 . LEU A 1 30  ? 102.302 112.003 97.536  1.00 81.55  ?  30  LEU A CD2 1 
ATOM 233  N N   . MET A 1 31  ? 106.121 110.263 101.396 1.00 92.66  ?  31  MET A N   1 
ATOM 234  C CA  . MET A 1 31  ? 106.399 109.239 102.394 1.00 93.71  ?  31  MET A CA  1 
ATOM 235  C C   . MET A 1 31  ? 105.473 109.488 103.548 1.00 98.14  ?  31  MET A C   1 
ATOM 236  O O   . MET A 1 31  ? 104.930 108.562 104.093 1.00 104.07 ?  31  MET A O   1 
ATOM 237  C CB  . MET A 1 31  ? 107.825 109.324 102.925 1.00 95.49  ?  31  MET A CB  1 
ATOM 238  C CG  . MET A 1 31  ? 108.909 108.763 102.027 1.00 101.03 ?  31  MET A CG  1 
ATOM 239  S SD  . MET A 1 31  ? 109.067 106.972 102.064 1.00 122.86 ?  31  MET A SD  1 
ATOM 240  C CE  . MET A 1 31  ? 109.315 106.598 103.800 1.00 97.61  ?  31  MET A CE  1 
ATOM 241  N N   . ALA A 1 32  ? 105.304 110.740 103.941 1.00 98.71  ?  32  ALA A N   1 
ATOM 242  C CA  . ALA A 1 32  ? 104.379 111.067 105.014 1.00 99.41  ?  32  ALA A CA  1 
ATOM 243  C C   . ALA A 1 32  ? 102.998 110.688 104.594 1.00 97.28  ?  32  ALA A C   1 
ATOM 244  O O   . ALA A 1 32  ? 102.233 110.176 105.384 1.00 103.02 ?  32  ALA A O   1 
ATOM 245  C CB  . ALA A 1 32  ? 104.419 112.542 105.340 1.00 96.28  ?  32  ALA A CB  1 
ATOM 246  N N   . SER A 1 33  ? 102.677 110.923 103.334 1.00 93.17  ?  33  SER A N   1 
ATOM 247  C CA  . SER A 1 33  ? 101.352 110.630 102.842 1.00 81.04  ?  33  SER A CA  1 
ATOM 248  C C   . SER A 1 33  ? 101.038 109.163 102.975 1.00 81.61  ?  33  SER A C   1 
ATOM 249  O O   . SER A 1 33  ? 99.934  108.846 103.324 1.00 101.68 ?  33  SER A O   1 
ATOM 250  C CB  . SER A 1 33  ? 101.180 111.103 101.410 1.00 81.93  ?  33  SER A CB  1 
ATOM 251  O OG  . SER A 1 33  ? 101.430 112.493 101.325 1.00 93.91  ?  33  SER A OG  1 
ATOM 252  N N   . HIS A 1 34  ? 101.994 108.280 102.723 1.00 83.97  ?  34  HIS A N   1 
ATOM 253  C CA  . HIS A 1 34  ? 101.799 106.828 102.867 1.00 91.04  ?  34  HIS A CA  1 
ATOM 254  C C   . HIS A 1 34  ? 101.848 106.296 104.284 1.00 95.85  ?  34  HIS A C   1 
ATOM 255  O O   . HIS A 1 34  ? 101.035 105.459 104.645 1.00 101.75 ?  34  HIS A O   1 
ATOM 256  C CB  . HIS A 1 34  ? 102.875 106.070 102.125 1.00 77.36  ?  34  HIS A CB  1 
ATOM 257  C CG  . HIS A 1 34  ? 102.493 105.675 100.746 1.00 87.88  ?  34  HIS A CG  1 
ATOM 258  N ND1 . HIS A 1 34  ? 102.829 106.416 99.636  1.00 88.83  ?  34  HIS A ND1 1 
ATOM 259  C CD2 . HIS A 1 34  ? 101.820 104.594 100.293 1.00 91.91  ?  34  HIS A CD2 1 
ATOM 260  C CE1 . HIS A 1 34  ? 102.374 105.809 98.558  1.00 94.83  ?  34  HIS A CE1 1 
ATOM 261  N NE2 . HIS A 1 34  ? 101.758 104.702 98.930  1.00 86.52  ?  34  HIS A NE2 1 
ATOM 262  N N   . ASN A 1 35  ? 102.823 106.734 105.078 1.00 98.20  ?  35  ASN A N   1 
ATOM 263  C CA  . ASN A 1 35  ? 102.967 106.266 106.455 1.00 96.30  ?  35  ASN A CA  1 
ATOM 264  C C   . ASN A 1 35  ? 101.715 106.541 107.242 1.00 95.94  ?  35  ASN A C   1 
ATOM 265  O O   . ASN A 1 35  ? 101.231 105.663 107.918 1.00 91.69  ?  35  ASN A O   1 
ATOM 266  C CB  . ASN A 1 35  ? 104.127 106.966 107.176 1.00 89.50  ?  35  ASN A CB  1 
ATOM 267  C CG  . ASN A 1 35  ? 105.494 106.606 106.629 1.00 96.86  ?  35  ASN A CG  1 
ATOM 268  O OD1 . ASN A 1 35  ? 105.630 105.796 105.725 1.00 101.22 ?  35  ASN A OD1 1 
ATOM 269  N ND2 . ASN A 1 35  ? 106.524 107.224 107.186 1.00 90.97  ?  35  ASN A ND2 1 
ATOM 270  N N   . THR A 1 36  ? 101.171 107.745 107.138 1.00 96.19  ?  36  THR A N   1 
ATOM 271  C CA  . THR A 1 36  ? 100.004 108.139 107.920 1.00 101.02 ?  36  THR A CA  1 
ATOM 272  C C   . THR A 1 36  ? 98.731  108.192 107.079 1.00 102.97 ?  36  THR A C   1 
ATOM 273  O O   . THR A 1 36  ? 97.783  108.862 107.460 1.00 111.25 ?  36  THR A O   1 
ATOM 274  C CB  . THR A 1 36  ? 100.267 109.502 108.564 1.00 102.46 ?  36  THR A CB  1 
ATOM 275  O OG1 . THR A 1 36  ? 100.315 110.513 107.557 1.00 102.22 ?  36  THR A OG1 1 
ATOM 276  C CG2 . THR A 1 36  ? 101.600 109.495 109.319 1.00 103.73 ?  36  THR A CG2 1 
ATOM 277  N N   . LEU A 1 37  ? 98.682  107.467 105.965 1.00 82.70  ?  37  LEU A N   1 
ATOM 278  C CA  . LEU A 1 37  ? 97.542  107.462 105.079 1.00 77.36  ?  37  LEU A CA  1 
ATOM 279  C C   . LEU A 1 37  ? 96.372  106.877 105.765 1.00 89.93  ?  37  LEU A C   1 
ATOM 280  O O   . LEU A 1 37  ? 95.286  107.272 105.459 1.00 101.36 ?  37  LEU A O   1 
ATOM 281  C CB  . LEU A 1 37  ? 97.840  106.635 103.824 1.00 77.94  ?  37  LEU A CB  1 
ATOM 282  C CG  . LEU A 1 37  ? 96.919  106.669 102.603 1.00 75.75  ?  37  LEU A CG  1 
ATOM 283  C CD1 . LEU A 1 37  ? 96.503  108.076 102.200 1.00 87.38  ?  37  LEU A CD1 1 
ATOM 284  C CD2 . LEU A 1 37  ? 97.573  105.949 101.432 1.00 79.51  ?  37  LEU A CD2 1 
ATOM 285  N N   . GLN A 1 38  ? 96.560  105.918 106.655 1.00 103.57 ?  38  GLN A N   1 
ATOM 286  C CA  . GLN A 1 38  ? 95.410  105.232 107.238 1.00 104.79 ?  38  GLN A CA  1 
ATOM 287  C C   . GLN A 1 38  ? 94.639  106.049 108.242 1.00 87.70  ?  38  GLN A C   1 
ATOM 288  O O   . GLN A 1 38  ? 93.721  105.541 108.862 1.00 71.94  ?  38  GLN A O   1 
ATOM 289  C CB  . GLN A 1 38  ? 95.834  103.919 107.884 1.00 103.77 ?  38  GLN A CB  1 
ATOM 290  C CG  . GLN A 1 38  ? 96.110  102.816 106.883 1.00 105.99 ?  38  GLN A CG  1 
ATOM 291  C CD  . GLN A 1 38  ? 95.904  101.441 107.475 1.00 98.11  ?  38  GLN A CD  1 
ATOM 292  O OE1 . GLN A 1 38  ? 95.471  101.304 108.617 1.00 94.39  ?  38  GLN A OE1 1 
ATOM 293  N NE2 . GLN A 1 38  ? 96.207  100.413 106.698 1.00 95.44  ?  38  GLN A NE2 1 
ATOM 294  N N   . ASN A 1 39  ? 94.997  107.306 108.423 1.00 100.34 ?  39  ASN A N   1 
ATOM 295  C CA  . ASN A 1 39  ? 94.224  108.148 109.304 1.00 103.73 ?  39  ASN A CA  1 
ATOM 296  C C   . ASN A 1 39  ? 93.084  108.639 108.471 1.00 86.17  ?  39  ASN A C   1 
ATOM 297  O O   . ASN A 1 39  ? 92.016  108.934 108.992 1.00 81.55  ?  39  ASN A O   1 
ATOM 298  C CB  . ASN A 1 39  ? 95.060  109.302 109.825 1.00 106.22 ?  39  ASN A CB  1 
ATOM 299  C CG  . ASN A 1 39  ? 96.079  108.868 110.846 1.00 100.02 ?  39  ASN A CG  1 
ATOM 300  O OD1 . ASN A 1 39  ? 97.155  109.449 110.947 1.00 99.60  ?  39  ASN A OD1 1 
ATOM 301  N ND2 . ASN A 1 39  ? 95.747  107.837 111.609 1.00 99.15  ?  39  ASN A ND2 1 
ATOM 302  N N   . PHE A 1 40  ? 93.305  108.739 107.167 1.00 91.09  ?  40  PHE A N   1 
ATOM 303  C CA  . PHE A 1 40  ? 92.248  109.150 106.238 1.00 96.44  ?  40  PHE A CA  1 
ATOM 304  C C   . PHE A 1 40  ? 91.618  108.004 105.428 1.00 99.94  ?  40  PHE A C   1 
ATOM 305  O O   . PHE A 1 40  ? 90.420  108.049 105.167 1.00 101.57 ?  40  PHE A O   1 
ATOM 306  C CB  . PHE A 1 40  ? 92.820  110.195 105.281 1.00 92.28  ?  40  PHE A CB  1 
ATOM 307  C CG  . PHE A 1 40  ? 93.392  111.398 105.975 1.00 87.97  ?  40  PHE A CG  1 
ATOM 308  C CD1 . PHE A 1 40  ? 92.583  112.463 106.303 1.00 87.07  ?  40  PHE A CD1 1 
ATOM 309  C CD2 . PHE A 1 40  ? 94.733  111.459 106.304 1.00 90.89  ?  40  PHE A CD2 1 
ATOM 310  C CE1 . PHE A 1 40  ? 93.093  113.566 106.946 1.00 90.83  ?  40  PHE A CE1 1 
ATOM 311  C CE2 . PHE A 1 40  ? 95.247  112.561 106.952 1.00 91.85  ?  40  PHE A CE2 1 
ATOM 312  C CZ  . PHE A 1 40  ? 94.424  113.616 107.268 1.00 95.75  ?  40  PHE A CZ  1 
ATOM 313  N N   . THR A 1 41  ? 92.395  106.990 105.032 1.00 96.53  ?  41  THR A N   1 
ATOM 314  C CA  . THR A 1 41  ? 91.863  105.853 104.277 1.00 84.07  ?  41  THR A CA  1 
ATOM 315  C C   . THR A 1 41  ? 91.190  104.853 105.187 1.00 83.84  ?  41  THR A C   1 
ATOM 316  O O   . THR A 1 41  ? 90.464  104.038 104.677 1.00 82.79  ?  41  THR A O   1 
ATOM 317  C CB  . THR A 1 41  ? 92.929  105.119 103.430 1.00 81.17  ?  41  THR A CB  1 
ATOM 318  O OG1 . THR A 1 41  ? 94.060  104.795 104.239 1.00 72.83  ?  41  THR A OG1 1 
ATOM 319  C CG2 . THR A 1 41  ? 93.360  105.971 102.246 1.00 90.62  ?  41  THR A CG2 1 
ATOM 320  N N   . ALA A 1 42  ? 91.423  104.908 106.503 1.00 99.90  ?  42  ALA A N   1 
ATOM 321  C CA  . ALA A 1 42  ? 90.794  104.024 107.460 1.00 94.51  ?  42  ALA A CA  1 
ATOM 322  C C   . ALA A 1 42  ? 90.009  104.711 108.542 1.00 95.73  ?  42  ALA A C   1 
ATOM 323  O O   . ALA A 1 42  ? 89.713  104.119 109.558 1.00 96.36  ?  42  ALA A O   1 
ATOM 324  C CB  . ALA A 1 42  ? 91.823  103.145 108.079 1.00 89.80  ?  42  ALA A CB  1 
ATOM 325  N N   . ALA A 1 43  ? 89.626  105.964 108.337 1.00 86.75  ?  43  ALA A N   1 
ATOM 326  C CA  . ALA A 1 43  ? 88.925  106.699 109.370 1.00 84.40  ?  43  ALA A CA  1 
ATOM 327  C C   . ALA A 1 43  ? 87.698  105.930 109.746 1.00 85.18  ?  43  ALA A C   1 
ATOM 328  O O   . ALA A 1 43  ? 87.143  105.251 108.910 1.00 88.80  ?  43  ALA A O   1 
ATOM 329  C CB  . ALA A 1 43  ? 88.547  108.084 108.895 1.00 89.17  ?  43  ALA A CB  1 
ATOM 330  N N   . ILE A 1 44  ? 87.260  106.040 110.991 1.00 87.15  ?  44  ILE A N   1 
ATOM 331  C CA  . ILE A 1 44  ? 86.122  105.268 111.465 1.00 92.87  ?  44  ILE A CA  1 
ATOM 332  C C   . ILE A 1 44  ? 84.867  106.144 111.445 1.00 87.43  ?  44  ILE A C   1 
ATOM 333  O O   . ILE A 1 44  ? 84.714  106.999 112.309 1.00 93.14  ?  44  ILE A O   1 
ATOM 334  C CB  . ILE A 1 44  ? 86.373  104.675 112.876 1.00 91.57  ?  44  ILE A CB  1 
ATOM 335  C CG1 . ILE A 1 44  ? 87.750  103.987 112.924 1.00 91.97  ?  44  ILE A CG1 1 
ATOM 336  C CG2 . ILE A 1 44  ? 85.252  103.708 113.257 1.00 88.09  ?  44  ILE A CG2 1 
ATOM 337  C CD1 . ILE A 1 44  ? 88.026  103.168 114.166 1.00 82.87  ?  44  ILE A CD1 1 
ATOM 338  N N   . PRO A 1 45  ? 83.966  105.949 110.456 1.00 86.47  ?  45  PRO A N   1 
ATOM 339  C CA  . PRO A 1 45  ? 82.733  106.721 110.515 1.00 91.11  ?  45  PRO A CA  1 
ATOM 340  C C   . PRO A 1 45  ? 81.881  106.216 111.662 1.00 89.08  ?  45  PRO A C   1 
ATOM 341  O O   . PRO A 1 45  ? 82.055  105.080 112.076 1.00 96.97  ?  45  PRO A O   1 
ATOM 342  C CB  . PRO A 1 45  ? 82.075  106.415 109.182 1.00 98.48  ?  45  PRO A CB  1 
ATOM 343  C CG  . PRO A 1 45  ? 82.616  105.099 108.775 1.00 94.36  ?  45  PRO A CG  1 
ATOM 344  C CD  . PRO A 1 45  ? 84.018  105.067 109.281 1.00 89.45  ?  45  PRO A CD  1 
ATOM 345  N N   . THR A 1 46  ? 80.956  107.027 112.172 1.00 99.72  ?  46  THR A N   1 
ATOM 346  C CA  . THR A 1 46  ? 80.060  106.582 113.225 1.00 103.28 ?  46  THR A CA  1 
ATOM 347  C C   . THR A 1 46  ? 79.197  105.469 112.687 1.00 105.37 ?  46  THR A C   1 
ATOM 348  O O   . THR A 1 46  ? 78.507  105.680 111.716 1.00 111.41 ?  46  THR A O   1 
ATOM 349  C CB  . THR A 1 46  ? 79.148  107.725 113.697 1.00 105.90 ?  46  THR A CB  1 
ATOM 350  O OG1 . THR A 1 46  ? 79.956  108.818 114.145 1.00 109.44 ?  46  THR A OG1 1 
ATOM 351  C CG2 . THR A 1 46  ? 78.226  107.264 114.832 1.00 104.51 ?  46  THR A CG2 1 
ATOM 352  N N   . HIS A 1 47  ? 79.147  104.326 113.345 1.00 107.70 ?  47  HIS A N   1 
ATOM 353  C CA  . HIS A 1 47  ? 78.441  103.186 112.811 1.00 106.76 ?  47  HIS A CA  1 
ATOM 354  C C   . HIS A 1 47  ? 77.460  102.790 113.844 1.00 105.62 ?  47  HIS A C   1 
ATOM 355  O O   . HIS A 1 47  ? 77.752  102.895 115.019 1.00 119.87 ?  47  HIS A O   1 
ATOM 356  C CB  . HIS A 1 47  ? 79.427  102.073 112.543 1.00 103.78 ?  47  HIS A CB  1 
ATOM 357  C CG  . HIS A 1 47  ? 80.468  101.939 113.596 1.00 105.58 ?  47  HIS A CG  1 
ATOM 358  N ND1 . HIS A 1 47  ? 81.575  102.755 113.675 1.00 108.95 ?  47  HIS A ND1 1 
ATOM 359  C CD2 . HIS A 1 47  ? 80.534  101.113 114.653 1.00 113.62 ?  47  HIS A CD2 1 
ATOM 360  C CE1 . HIS A 1 47  ? 82.291  102.418 114.732 1.00 111.83 ?  47  HIS A CE1 1 
ATOM 361  N NE2 . HIS A 1 47  ? 81.683  101.419 115.341 1.00 112.30 ?  47  HIS A NE2 1 
ATOM 362  N N   . HIS A 1 48  ? 76.271  102.409 113.429 1.00 106.73 ?  48  HIS A N   1 
ATOM 363  C CA  . HIS A 1 48  ? 75.271  101.934 114.345 1.00 113.15 ?  48  HIS A CA  1 
ATOM 364  C C   . HIS A 1 48  ? 74.752  100.770 113.596 1.00 116.97 ?  48  HIS A C   1 
ATOM 365  O O   . HIS A 1 48  ? 74.933  100.693 112.410 1.00 123.98 ?  48  HIS A O   1 
ATOM 366  C CB  . HIS A 1 48  ? 74.184  102.959 114.620 1.00 115.60 ?  48  HIS A CB  1 
ATOM 367  C CG  . HIS A 1 48  ? 73.530  103.518 113.397 1.00 118.26 ?  48  HIS A CG  1 
ATOM 368  N ND1 . HIS A 1 48  ? 73.910  104.720 112.841 1.00 114.72 ?  48  HIS A ND1 1 
ATOM 369  C CD2 . HIS A 1 48  ? 72.507  103.060 112.639 1.00 120.83 ?  48  HIS A CD2 1 
ATOM 370  C CE1 . HIS A 1 48  ? 73.158  104.971 111.786 1.00 117.72 ?  48  HIS A CE1 1 
ATOM 371  N NE2 . HIS A 1 48  ? 72.297  103.981 111.643 1.00 118.79 ?  48  HIS A NE2 1 
ATOM 372  N N   . CYS A 1 49  ? 74.159  99.825  114.278 1.00 124.97 ?  49  CYS A N   1 
ATOM 373  C CA  . CYS A 1 49  ? 73.714  98.625  113.614 1.00 125.75 ?  49  CYS A CA  1 
ATOM 374  C C   . CYS A 1 49  ? 72.568  98.797  112.663 1.00 126.18 ?  49  CYS A C   1 
ATOM 375  O O   . CYS A 1 49  ? 71.707  99.635  112.877 1.00 127.11 ?  49  CYS A O   1 
ATOM 376  C CB  . CYS A 1 49  ? 73.298  97.624  114.637 1.00 128.60 ?  49  CYS A CB  1 
ATOM 377  S SG  . CYS A 1 49  ? 74.700  96.886  115.424 1.00 143.46 ?  49  CYS A SG  1 
ATOM 378  N N   . ARG A 1 50  ? 72.537  97.971  111.627 1.00 123.75 ?  50  ARG A N   1 
ATOM 379  C CA  . ARG A 1 50  ? 71.463  98.036  110.664 1.00 123.77 ?  50  ARG A CA  1 
ATOM 380  C C   . ARG A 1 50  ? 70.238  97.358  111.269 1.00 129.62 ?  50  ARG A C   1 
ATOM 381  O O   . ARG A 1 50  ? 70.338  96.223  111.721 1.00 133.72 ?  50  ARG A O   1 
ATOM 382  C CB  . ARG A 1 50  ? 71.850  97.362  109.361 1.00 126.32 ?  50  ARG A CB  1 
ATOM 383  C CG  . ARG A 1 50  ? 70.940  97.709  108.192 1.00 123.84 ?  50  ARG A CG  1 
ATOM 384  C CD  . ARG A 1 50  ? 71.473  97.151  106.884 1.00 124.83 ?  50  ARG A CD  1 
ATOM 385  N NE  . ARG A 1 50  ? 72.828  97.628  106.594 1.00 128.88 ?  50  ARG A NE  1 
ATOM 386  C CZ  . ARG A 1 50  ? 73.625  97.166  105.627 1.00 126.30 ?  50  ARG A CZ  1 
ATOM 387  N NH1 . ARG A 1 50  ? 73.230  96.196  104.797 1.00 125.65 1  50  ARG A NH1 1 
ATOM 388  N NH2 . ARG A 1 50  ? 74.843  97.689  105.484 1.00 124.53 ?  50  ARG A NH2 1 
ATOM 389  N N   . PRO A 1 51  ? 69.079  98.045  111.294 1.00 138.93 ?  51  PRO A N   1 
ATOM 390  C CA  . PRO A 1 51  ? 67.867  97.409  111.802 1.00 137.23 ?  51  PRO A CA  1 
ATOM 391  C C   . PRO A 1 51  ? 67.510  96.219  110.935 1.00 142.04 ?  51  PRO A C   1 
ATOM 392  O O   . PRO A 1 51  ? 67.866  96.201  109.760 1.00 144.44 ?  51  PRO A O   1 
ATOM 393  C CB  . PRO A 1 51  ? 66.817  98.497  111.628 1.00 138.45 ?  51  PRO A CB  1 
ATOM 394  C CG  . PRO A 1 51  ? 67.579  99.772  111.681 1.00 141.08 ?  51  PRO A CG  1 
ATOM 395  C CD  . PRO A 1 51  ? 68.869  99.468  110.987 1.00 139.92 ?  51  PRO A CD  1 
ATOM 396  N N   . PRO A 1 52  ? 66.820  95.221  111.500 1.00 155.93 ?  52  PRO A N   1 
ATOM 397  C CA  . PRO A 1 52  ? 66.545  94.014  110.717 1.00 154.79 ?  52  PRO A CA  1 
ATOM 398  C C   . PRO A 1 52  ? 65.771  94.329  109.458 1.00 157.12 ?  52  PRO A C   1 
ATOM 399  O O   . PRO A 1 52  ? 64.832  95.120  109.506 1.00 158.74 ?  52  PRO A O   1 
ATOM 400  C CB  . PRO A 1 52  ? 65.675  93.189  111.657 1.00 153.55 ?  52  PRO A CB  1 
ATOM 401  C CG  . PRO A 1 52  ? 66.109  93.603  113.017 1.00 152.64 ?  52  PRO A CG  1 
ATOM 402  C CD  . PRO A 1 52  ? 66.446  95.062  112.913 1.00 154.24 ?  52  PRO A CD  1 
ATOM 403  N N   . ALA A 1 53  ? 66.151  93.720  108.342 1.00 161.85 ?  53  ALA A N   1 
ATOM 404  C CA  . ALA A 1 53  ? 65.514  94.031  107.063 1.00 164.06 ?  53  ALA A CA  1 
ATOM 405  C C   . ALA A 1 53  ? 64.015  93.792  107.059 1.00 165.08 ?  53  ALA A C   1 
ATOM 406  O O   . ALA A 1 53  ? 63.264  94.583  106.491 1.00 161.61 ?  53  ALA A O   1 
ATOM 407  C CB  . ALA A 1 53  ? 66.173  93.239  105.945 1.00 161.91 ?  53  ALA A CB  1 
ATOM 408  N N   . ASP A 1 54  ? 63.577  92.702  107.679 1.00 172.88 ?  54  ASP A N   1 
ATOM 409  C CA  . ASP A 1 54  ? 62.159  92.376  107.706 1.00 171.50 ?  54  ASP A CA  1 
ATOM 410  C C   . ASP A 1 54  ? 61.391  93.502  108.358 1.00 171.01 ?  54  ASP A C   1 
ATOM 411  O O   . ASP A 1 54  ? 60.298  93.852  107.918 1.00 170.10 ?  54  ASP A O   1 
ATOM 412  C CB  . ASP A 1 54  ? 61.940  91.087  108.492 1.00 170.60 ?  54  ASP A CB  1 
ATOM 413  C CG  . ASP A 1 54  ? 62.605  89.887  107.841 1.00 171.61 ?  54  ASP A CG  1 
ATOM 414  O OD1 . ASP A 1 54  ? 63.084  90.016  106.695 1.00 171.81 ?  54  ASP A OD1 1 
ATOM 415  O OD2 . ASP A 1 54  ? 62.643  88.811  108.474 1.00 172.16 -1 54  ASP A OD2 1 
ATOM 416  N N   . ALA A 1 55  ? 61.957  94.074  109.410 1.00 177.58 ?  55  ALA A N   1 
ATOM 417  C CA  . ALA A 1 55  ? 61.306  95.169  110.111 1.00 178.73 ?  55  ALA A CA  1 
ATOM 418  C C   . ALA A 1 55  ? 61.159  96.394  109.227 1.00 180.72 ?  55  ALA A C   1 
ATOM 419  O O   . ALA A 1 55  ? 62.059  96.719  108.454 1.00 179.36 ?  55  ALA A O   1 
ATOM 420  C CB  . ALA A 1 55  ? 62.106  95.516  111.341 1.00 177.28 ?  55  ALA A CB  1 
ATOM 421  N N   . ASN A 1 56  ? 59.999  97.062  109.282 1.00 194.51 ?  56  ASN A N   1 
ATOM 422  C CA  . ASN A 1 56  ? 59.749  98.232  108.439 1.00 193.37 ?  56  ASN A CA  1 
ATOM 423  C C   . ASN A 1 56  ? 59.995  99.433  109.307 1.00 193.38 ?  56  ASN A C   1 
ATOM 424  O O   . ASN A 1 56  ? 59.457  99.502  110.395 1.00 193.11 ?  56  ASN A O   1 
ATOM 425  C CB  . ASN A 1 56  ? 58.301  98.273  107.940 1.00 192.78 ?  56  ASN A CB  1 
ATOM 426  N N   . LEU A 1 57  ? 60.803  100.374 108.839 1.00 197.04 ?  57  LEU A N   1 
ATOM 427  C CA  . LEU A 1 57  ? 61.133  101.545 109.645 1.00 197.89 ?  57  LEU A CA  1 
ATOM 428  C C   . LEU A 1 57  ? 60.011  102.570 109.649 1.00 198.12 ?  57  LEU A C   1 
ATOM 429  O O   . LEU A 1 57  ? 59.848  103.273 110.636 1.00 196.64 ?  57  LEU A O   1 
ATOM 430  C CB  . LEU A 1 57  ? 62.466  102.168 109.212 1.00 197.43 ?  57  LEU A CB  1 
ATOM 431  N N   . SER A 1 58  ? 59.244  102.659 108.561 1.00 199.64 ?  58  SER A N   1 
ATOM 432  C CA  . SER A 1 58  ? 58.099  103.560 108.536 1.00 199.46 ?  58  SER A CA  1 
ATOM 433  C C   . SER A 1 58  ? 57.135  103.133 109.625 1.00 198.35 ?  58  SER A C   1 
ATOM 434  O O   . SER A 1 58  ? 56.602  103.972 110.352 1.00 196.83 ?  58  SER A O   1 
ATOM 435  C CB  . SER A 1 58  ? 57.407  103.506 107.177 1.00 197.99 ?  58  SER A CB  1 
ATOM 436  N N   . LYS A 1 59  ? 56.923  101.828 109.749 1.00 197.64 ?  59  LYS A N   1 
ATOM 437  C CA  . LYS A 1 59  ? 56.015  101.311 110.767 1.00 197.77 ?  59  LYS A CA  1 
ATOM 438  C C   . LYS A 1 59  ? 56.626  101.422 112.150 1.00 197.84 ?  59  LYS A C   1 
ATOM 439  O O   . LYS A 1 59  ? 55.924  101.820 113.082 1.00 195.81 ?  59  LYS A O   1 
ATOM 440  C CB  . LYS A 1 59  ? 55.690  99.836  110.513 1.00 197.00 ?  59  LYS A CB  1 
ATOM 441  N N   . ASN A 1 60  ? 57.923  101.096 112.290 1.00 200.36 ?  60  ASN A N   1 
ATOM 442  C CA  . ASN A 1 60  ? 58.581  101.068 113.609 1.00 201.47 ?  60  ASN A CA  1 
ATOM 443  C C   . ASN A 1 60  ? 59.298  102.359 113.999 1.00 200.18 ?  60  ASN A C   1 
ATOM 444  O O   . ASN A 1 60  ? 60.101  102.359 114.930 1.00 199.98 ?  60  ASN A O   1 
ATOM 445  C CB  . ASN A 1 60  ? 59.589  99.902  113.692 1.00 199.89 ?  60  ASN A CB  1 
ATOM 446  N N   . GLY A 1 61  ? 59.027  103.456 113.304 1.00 192.90 ?  61  GLY A N   1 
ATOM 447  C CA  . GLY A 1 61  ? 59.620  104.734 113.664 1.00 192.12 ?  61  GLY A CA  1 
ATOM 448  C C   . GLY A 1 61  ? 61.132  104.808 113.631 1.00 192.99 ?  61  GLY A C   1 
ATOM 449  O O   . GLY A 1 61  ? 61.723  105.498 114.462 1.00 191.87 ?  61  GLY A O   1 
ATOM 450  N N   . GLY A 1 62  ? 61.770  104.102 112.702 1.00 187.53 ?  62  GLY A N   1 
ATOM 451  C CA  . GLY A 1 62  ? 63.211  104.215 112.541 1.00 186.64 ?  62  GLY A CA  1 
ATOM 452  C C   . GLY A 1 62  ? 64.147  103.570 113.539 1.00 186.27 ?  62  GLY A C   1 
ATOM 453  O O   . GLY A 1 62  ? 63.765  102.637 114.246 1.00 184.90 ?  62  GLY A O   1 
ATOM 454  N N   . LEU A 1 63  ? 65.385  104.058 113.583 1.00 174.47 ?  63  LEU A N   1 
ATOM 455  C CA  . LEU A 1 63  ? 66.394  103.504 114.483 1.00 172.50 ?  63  LEU A CA  1 
ATOM 456  C C   . LEU A 1 63  ? 66.004  103.494 115.953 1.00 171.63 ?  63  LEU A C   1 
ATOM 457  O O   . LEU A 1 63  ? 66.492  102.652 116.699 1.00 171.74 ?  63  LEU A O   1 
ATOM 458  C CB  . LEU A 1 63  ? 67.697  104.298 114.372 1.00 172.60 ?  63  LEU A CB  1 
ATOM 459  C CG  . LEU A 1 63  ? 68.485  104.379 113.059 1.00 171.43 ?  63  LEU A CG  1 
ATOM 460  C CD1 . LEU A 1 63  ? 69.766  105.164 113.296 1.00 169.82 ?  63  LEU A CD1 1 
ATOM 461  C CD2 . LEU A 1 63  ? 68.788  103.001 112.486 1.00 171.81 ?  63  LEU A CD2 1 
ATOM 462  N N   . GLU A 1 64  ? 65.157  104.418 116.392 1.00 176.75 ?  64  GLU A N   1 
ATOM 463  C CA  . GLU A 1 64  ? 64.843  104.477 117.821 1.00 177.04 ?  64  GLU A CA  1 
ATOM 464  C C   . GLU A 1 64  ? 64.444  103.118 118.387 1.00 177.66 ?  64  GLU A C   1 
ATOM 465  O O   . GLU A 1 64  ? 64.961  102.714 119.429 1.00 174.48 ?  64  GLU A O   1 
ATOM 466  C CB  . GLU A 1 64  ? 63.683  105.450 118.085 1.00 177.42 ?  64  GLU A CB  1 
ATOM 467  N N   . VAL A 1 65  ? 63.549  102.404 117.709 1.00 181.14 ?  65  VAL A N   1 
ATOM 468  C CA  . VAL A 1 65  ? 63.019  101.127 118.225 1.00 180.96 ?  65  VAL A CA  1 
ATOM 469  C C   . VAL A 1 65  ? 64.007  99.996  118.137 1.00 179.53 ?  65  VAL A C   1 
ATOM 470  O O   . VAL A 1 65  ? 63.996  99.120  118.994 1.00 180.46 ?  65  VAL A O   1 
ATOM 471  C CB  . VAL A 1 65  ? 61.698  100.739 117.477 1.00 180.57 ?  65  VAL A CB  1 
ATOM 472  C CG1 . VAL A 1 65  ? 61.364  99.248  117.538 1.00 178.81 ?  65  VAL A CG1 1 
ATOM 473  C CG2 . VAL A 1 65  ? 60.532  101.551 118.027 1.00 179.20 ?  65  VAL A CG2 1 
ATOM 474  N N   . TRP A 1 66  ? 64.918  100.022 117.164 1.00 165.20 ?  66  TRP A N   1 
ATOM 475  C CA  . TRP A 1 66  ? 65.840  98.903  116.947 1.00 162.14 ?  66  TRP A CA  1 
ATOM 476  C C   . TRP A 1 66  ? 67.268  99.081  117.427 1.00 161.39 ?  66  TRP A C   1 
ATOM 477  O O   . TRP A 1 66  ? 68.089  98.203  117.179 1.00 162.41 ?  66  TRP A O   1 
ATOM 478  C CB  . TRP A 1 66  ? 65.860  98.560  115.456 1.00 162.74 ?  66  TRP A CB  1 
ATOM 479  C CG  . TRP A 1 66  ? 64.592  97.962  115.015 1.00 163.72 ?  66  TRP A CG  1 
ATOM 480  C CD1 . TRP A 1 66  ? 63.608  98.559  114.291 1.00 166.02 ?  66  TRP A CD1 1 
ATOM 481  C CD2 . TRP A 1 66  ? 64.146  96.635  115.289 1.00 165.00 ?  66  TRP A CD2 1 
ATOM 482  N NE1 . TRP A 1 66  ? 62.578  97.679  114.088 1.00 167.94 ?  66  TRP A NE1 1 
ATOM 483  C CE2 . TRP A 1 66  ? 62.886  96.489  114.691 1.00 167.27 ?  66  TRP A CE2 1 
ATOM 484  C CE3 . TRP A 1 66  ? 64.697  95.553  115.978 1.00 164.72 ?  66  TRP A CE3 1 
ATOM 485  C CZ2 . TRP A 1 66  ? 62.167  95.304  114.759 1.00 165.71 ?  66  TRP A CZ2 1 
ATOM 486  C CZ3 . TRP A 1 66  ? 63.982  94.382  116.046 1.00 164.85 ?  66  TRP A CZ3 1 
ATOM 487  C CH2 . TRP A 1 66  ? 62.732  94.264  115.440 1.00 164.25 ?  66  TRP A CH2 1 
ATOM 488  N N   . LEU A 1 67  ? 67.566  100.179 118.115 1.00 156.83 ?  67  LEU A N   1 
ATOM 489  C CA  . LEU A 1 67  ? 68.931  100.438 118.571 1.00 158.71 ?  67  LEU A CA  1 
ATOM 490  C C   . LEU A 1 67  ? 69.083  100.762 120.060 1.00 160.55 ?  67  LEU A C   1 
ATOM 491  O O   . LEU A 1 67  ? 68.532  101.758 120.523 1.00 158.59 ?  67  LEU A O   1 
ATOM 492  C CB  . LEU A 1 67  ? 69.603  101.521 117.743 1.00 158.73 ?  67  LEU A CB  1 
ATOM 493  C CG  . LEU A 1 67  ? 70.124  101.094 116.370 1.00 157.15 ?  67  LEU A CG  1 
ATOM 494  C CD1 . LEU A 1 67  ? 70.817  102.285 115.765 1.00 157.46 ?  67  LEU A CD1 1 
ATOM 495  C CD2 . LEU A 1 67  ? 71.104  99.922  116.419 1.00 155.94 ?  67  LEU A CD2 1 
ATOM 496  N N   . PRO A 1 68  ? 69.848  99.929  120.815 1.00 164.62 ?  68  PRO A N   1 
ATOM 497  C CA  . PRO A 1 68  ? 70.071  100.280 122.218 1.00 165.18 ?  68  PRO A CA  1 
ATOM 498  C C   . PRO A 1 68  ? 70.909  101.543 122.339 1.00 164.39 ?  68  PRO A C   1 
ATOM 499  O O   . PRO A 1 68  ? 71.820  101.727 121.538 1.00 165.32 ?  68  PRO A O   1 
ATOM 500  C CB  . PRO A 1 68  ? 70.833  99.073  122.764 1.00 163.88 ?  68  PRO A CB  1 
ATOM 501  C CG  . PRO A 1 68  ? 71.311  98.321  121.575 1.00 159.00 ?  68  PRO A CG  1 
ATOM 502  C CD  . PRO A 1 68  ? 70.285  98.561  120.520 1.00 158.95 ?  68  PRO A CD  1 
ATOM 503  N N   . ARG A 1 69  ? 70.654  102.411 123.329 1.00 171.44 ?  69  ARG A N   1 
ATOM 504  C CA  . ARG A 1 69  ? 71.392  103.679 123.452 1.00 171.75 ?  69  ARG A CA  1 
ATOM 505  C C   . ARG A 1 69  ? 72.397  103.665 124.594 1.00 171.49 ?  69  ARG A C   1 
ATOM 506  O O   . ARG A 1 69  ? 72.089  103.174 125.677 1.00 170.43 ?  69  ARG A O   1 
ATOM 507  C CB  . ARG A 1 69  ? 70.458  104.883 123.609 1.00 173.79 ?  69  ARG A CB  1 
ATOM 508  N N   . ASP A 1 70  ? 73.592  104.206 124.357 1.00 175.66 ?  70  ASP A N   1 
ATOM 509  C CA  . ASP A 1 70  ? 74.639  104.262 125.384 1.00 176.27 ?  70  ASP A CA  1 
ATOM 510  C C   . ASP A 1 70  ? 74.397  105.451 126.320 1.00 176.44 ?  70  ASP A C   1 
ATOM 511  O O   . ASP A 1 70  ? 73.438  106.191 126.127 1.00 173.62 ?  70  ASP A O   1 
ATOM 512  C CB  . ASP A 1 70  ? 76.040  104.297 124.751 1.00 174.10 ?  70  ASP A CB  1 
ATOM 513  C CG  . ASP A 1 70  ? 76.386  105.637 124.130 1.00 175.13 ?  70  ASP A CG  1 
ATOM 514  O OD1 . ASP A 1 70  ? 75.477  106.352 123.673 1.00 176.49 ?  70  ASP A OD1 1 
ATOM 515  O OD2 . ASP A 1 70  ? 77.589  105.968 124.083 1.00 173.64 -1 70  ASP A OD2 1 
ATOM 516  N N   . ARG A 1 71  ? 75.198  105.590 127.374 1.00 179.95 ?  71  ARG A N   1 
ATOM 517  C CA  . ARG A 1 71  ? 75.065  106.735 128.287 1.00 180.90 ?  71  ARG A CA  1 
ATOM 518  C C   . ARG A 1 71  ? 74.977  108.073 127.547 1.00 180.27 ?  71  ARG A C   1 
ATOM 519  O O   . ARG A 1 71  ? 74.153  108.913 127.903 1.00 179.59 ?  71  ARG A O   1 
ATOM 520  C CB  . ARG A 1 71  ? 76.239  106.794 129.264 1.00 180.44 ?  71  ARG A CB  1 
ATOM 521  C CG  . ARG A 1 71  ? 76.219  105.725 130.345 1.00 178.33 ?  71  ARG A CG  1 
ATOM 522  C CD  . ARG A 1 71  ? 77.344  105.924 131.348 1.00 179.01 ?  71  ARG A CD  1 
ATOM 523  N NE  . ARG A 1 71  ? 77.326  104.895 132.389 1.00 180.39 ?  71  ARG A NE  1 
ATOM 524  C CZ  . ARG A 1 71  ? 78.180  104.810 133.416 1.00 180.14 ?  71  ARG A CZ  1 
ATOM 525  N NH1 . ARG A 1 71  ? 79.167  105.698 133.578 1.00 178.81 1  71  ARG A NH1 1 
ATOM 526  N NH2 . ARG A 1 71  ? 78.046  103.818 134.297 1.00 179.17 ?  71  ARG A NH2 1 
ATOM 527  N N   . GLN A 1 72  ? 75.779  108.255 126.496 1.00 178.51 ?  72  GLN A N   1 
ATOM 528  C CA  . GLN A 1 72  ? 75.758  109.502 125.723 1.00 178.55 ?  72  GLN A CA  1 
ATOM 529  C C   . GLN A 1 72  ? 74.414  109.795 125.063 1.00 179.04 ?  72  GLN A C   1 
ATOM 530  O O   . GLN A 1 72  ? 74.161  110.938 124.678 1.00 178.09 ?  72  GLN A O   1 
ATOM 531  C CB  . GLN A 1 72  ? 76.830  109.490 124.626 1.00 178.35 ?  72  GLN A CB  1 
ATOM 532  C CG  . GLN A 1 72  ? 78.270  109.477 125.121 1.00 177.84 ?  72  GLN A CG  1 
ATOM 533  C CD  . GLN A 1 72  ? 79.282  109.548 123.991 1.00 177.52 ?  72  GLN A CD  1 
ATOM 534  O OE1 . GLN A 1 72  ? 78.935  109.435 122.814 1.00 176.58 ?  72  GLN A OE1 1 
ATOM 535  N NE2 . GLN A 1 72  ? 80.548  109.730 124.347 1.00 178.88 ?  72  GLN A NE2 1 
ATOM 536  N N   . GLY A 1 73  ? 73.555  108.788 124.921 1.00 179.86 ?  73  GLY A N   1 
ATOM 537  C CA  . GLY A 1 73  ? 72.274  108.964 124.254 1.00 178.66 ?  73  GLY A CA  1 
ATOM 538  C C   . GLY A 1 73  ? 72.397  108.794 122.758 1.00 179.62 ?  73  GLY A C   1 
ATOM 539  O O   . GLY A 1 73  ? 71.417  109.007 122.044 1.00 178.64 ?  73  GLY A O   1 
ATOM 540  N N   . GLN A 1 74  ? 73.559  108.343 122.274 1.00 174.09 ?  74  GLN A N   1 
ATOM 541  C CA  . GLN A 1 74  ? 73.757  108.103 120.850 1.00 173.20 ?  74  GLN A CA  1 
ATOM 542  C C   . GLN A 1 74  ? 73.532  106.616 120.590 1.00 172.01 ?  74  GLN A C   1 
ATOM 543  O O   . GLN A 1 74  ? 73.725  105.805 121.488 1.00 171.95 ?  74  GLN A O   1 
ATOM 544  C CB  . GLN A 1 74  ? 75.170  108.504 120.438 1.00 170.94 ?  74  GLN A CB  1 
ATOM 545  C CG  . GLN A 1 74  ? 75.549  109.926 120.830 1.00 171.03 ?  74  GLN A CG  1 
ATOM 546  C CD  . GLN A 1 74  ? 76.890  110.365 120.274 1.00 172.03 ?  74  GLN A CD  1 
ATOM 547  O OE1 . GLN A 1 74  ? 77.542  109.635 119.526 1.00 170.03 ?  74  GLN A OE1 1 
ATOM 548  N NE2 . GLN A 1 74  ? 77.312  111.570 120.641 1.00 172.30 ?  74  GLN A NE2 1 
ATOM 549  N N   . PRO A 1 75  ? 73.121  106.239 119.364 1.00 158.25 ?  75  PRO A N   1 
ATOM 550  C CA  . PRO A 1 75  ? 72.859  104.812 119.173 1.00 155.96 ?  75  PRO A CA  1 
ATOM 551  C C   . PRO A 1 75  ? 74.102  103.937 119.355 1.00 157.04 ?  75  PRO A C   1 
ATOM 552  O O   . PRO A 1 75  ? 75.160  104.300 118.843 1.00 154.22 ?  75  PRO A O   1 
ATOM 553  C CB  . PRO A 1 75  ? 72.388  104.734 117.727 1.00 154.79 ?  75  PRO A CB  1 
ATOM 554  C CG  . PRO A 1 75  ? 72.813  105.995 117.077 1.00 154.65 ?  75  PRO A CG  1 
ATOM 555  C CD  . PRO A 1 75  ? 72.790  107.020 118.158 1.00 156.91 ?  75  PRO A CD  1 
ATOM 556  N N   . GLU A 1 76  ? 73.979  102.807 120.052 1.00 142.62 ?  76  GLU A N   1 
ATOM 557  C CA  . GLU A 1 76  ? 75.128  101.938 120.314 1.00 139.03 ?  76  GLU A CA  1 
ATOM 558  C C   . GLU A 1 76  ? 75.663  101.312 119.039 1.00 139.75 ?  76  GLU A C   1 
ATOM 559  O O   . GLU A 1 76  ? 74.893  100.794 118.234 1.00 139.69 ?  76  GLU A O   1 
ATOM 560  C CB  . GLU A 1 76  ? 74.757  100.845 121.318 1.00 137.64 ?  76  GLU A CB  1 
ATOM 561  C CG  . GLU A 1 76  ? 75.889  99.891  121.663 1.00 142.34 ?  76  GLU A CG  1 
ATOM 562  C CD  . GLU A 1 76  ? 75.648  99.131  122.952 1.00 144.59 ?  76  GLU A CD  1 
ATOM 563  O OE1 . GLU A 1 76  ? 76.639  98.686  123.566 1.00 142.67 ?  76  GLU A OE1 1 
ATOM 564  O OE2 . GLU A 1 76  ? 74.475  98.976  123.355 1.00 142.42 -1 76  GLU A OE2 1 
ATOM 565  N N   . SER A 1 77  ? 76.978  101.336 118.861 1.00 121.95 ?  77  SER A N   1 
ATOM 566  C CA  . SER A 1 77  ? 77.592  100.813 117.651 1.00 121.82 ?  77  SER A CA  1 
ATOM 567  C C   . SER A 1 77  ? 77.504  99.334  117.370 1.00 122.69 ?  77  SER A C   1 
ATOM 568  O O   . SER A 1 77  ? 77.296  98.966  116.225 1.00 124.11 ?  77  SER A O   1 
ATOM 569  C CB  . SER A 1 77  ? 79.061  101.202 117.644 1.00 118.29 ?  77  SER A CB  1 
ATOM 570  O OG  . SER A 1 77  ? 79.747  100.597 118.719 1.00 118.57 ?  77  SER A OG  1 
ATOM 571  N N   . CYS A 1 78  ? 77.668  98.487  118.378 1.00 129.38 ?  78  CYS A N   1 
ATOM 572  C CA  . CYS A 1 78  ? 77.738  97.038  118.165 1.00 123.11 ?  78  CYS A CA  1 
ATOM 573  C C   . CYS A 1 78  ? 76.561  96.179  118.564 1.00 117.75 ?  78  CYS A C   1 
ATOM 574  O O   . CYS A 1 78  ? 76.698  94.961  118.598 1.00 118.20 ?  78  CYS A O   1 
ATOM 575  C CB  . CYS A 1 78  ? 78.980  96.528  118.877 1.00 128.88 ?  78  CYS A CB  1 
ATOM 576  S SG  . CYS A 1 78  ? 80.459  97.413  118.359 1.00 143.16 ?  78  CYS A SG  1 
ATOM 577  N N   . LEU A 1 79  ? 75.422  96.782  118.875 1.00 137.60 ?  79  LEU A N   1 
ATOM 578  C CA  . LEU A 1 79  ? 74.263  96.016  119.310 1.00 139.40 ?  79  LEU A CA  1 
ATOM 579  C C   . LEU A 1 79  ? 72.957  96.505  118.733 1.00 140.60 ?  79  LEU A C   1 
ATOM 580  O O   . LEU A 1 79  ? 72.841  97.683  118.431 1.00 149.36 ?  79  LEU A O   1 
ATOM 581  C CB  . LEU A 1 79  ? 74.171  96.017  120.831 1.00 143.11 ?  79  LEU A CB  1 
ATOM 582  C CG  . LEU A 1 79  ? 75.095  95.074  121.609 1.00 144.32 ?  79  LEU A CG  1 
ATOM 583  C CD1 . LEU A 1 79  ? 74.951  95.331  123.102 1.00 141.35 ?  79  LEU A CD1 1 
ATOM 584  C CD2 . LEU A 1 79  ? 74.861  93.602  121.267 1.00 141.44 ?  79  LEU A CD2 1 
ATOM 585  N N   . ARG A 1 80  ? 71.989  95.607  118.557 1.00 140.57 ?  80  ARG A N   1 
ATOM 586  C CA  . ARG A 1 80  ? 70.667  95.975  118.062 1.00 143.57 ?  80  ARG A CA  1 
ATOM 587  C C   . ARG A 1 80  ? 69.691  95.170  118.880 1.00 148.05 ?  80  ARG A C   1 
ATOM 588  O O   . ARG A 1 80  ? 70.049  94.125  119.364 1.00 152.21 ?  80  ARG A O   1 
ATOM 589  C CB  . ARG A 1 80  ? 70.507  95.662  116.585 1.00 141.75 ?  80  ARG A CB  1 
ATOM 590  C CG  . ARG A 1 80  ? 70.524  94.199  116.206 1.00 143.46 ?  80  ARG A CG  1 
ATOM 591  C CD  . ARG A 1 80  ? 70.334  94.039  114.719 1.00 144.90 ?  80  ARG A CD  1 
ATOM 592  N NE  . ARG A 1 80  ? 70.092  92.642  114.390 1.00 149.18 ?  80  ARG A NE  1 
ATOM 593  C CZ  . ARG A 1 80  ? 69.702  92.197  113.197 1.00 149.37 ?  80  ARG A CZ  1 
ATOM 594  N NH1 . ARG A 1 80  ? 69.516  93.031  112.175 1.00 149.46 1  80  ARG A NH1 1 
ATOM 595  N NH2 . ARG A 1 80  ? 69.495  90.894  113.023 1.00 147.92 ?  80  ARG A NH2 1 
ATOM 596  N N   . PHE A 1 81  ? 68.466  95.643  119.048 1.00 161.54 ?  81  PHE A N   1 
ATOM 597  C CA  . PHE A 1 81  ? 67.514  94.936  119.895 1.00 159.95 ?  81  PHE A CA  1 
ATOM 598  C C   . PHE A 1 81  ? 67.028  93.676  119.197 1.00 158.87 ?  81  PHE A C   1 
ATOM 599  O O   . PHE A 1 81  ? 66.799  93.693  117.991 1.00 157.74 ?  81  PHE A O   1 
ATOM 600  C CB  . PHE A 1 81  ? 66.308  95.797  120.278 1.00 158.34 ?  81  PHE A CB  1 
ATOM 601  C CG  . PHE A 1 81  ? 66.594  96.813  121.346 1.00 159.44 ?  81  PHE A CG  1 
ATOM 602  C CD1 . PHE A 1 81  ? 66.900  96.411  122.635 1.00 161.18 ?  81  PHE A CD1 1 
ATOM 603  C CD2 . PHE A 1 81  ? 66.526  98.165  121.072 1.00 161.62 ?  81  PHE A CD2 1 
ATOM 604  C CE1 . PHE A 1 81  ? 67.158  97.336  123.621 1.00 160.78 ?  81  PHE A CE1 1 
ATOM 605  C CE2 . PHE A 1 81  ? 66.775  99.095  122.058 1.00 161.31 ?  81  PHE A CE2 1 
ATOM 606  C CZ  . PHE A 1 81  ? 67.091  98.681  123.334 1.00 159.89 ?  81  PHE A CZ  1 
ATOM 607  N N   . THR A 1 82  ? 66.873  92.584  119.945 1.00 166.17 ?  82  THR A N   1 
ATOM 608  C CA  . THR A 1 82  ? 66.389  91.342  119.364 1.00 167.40 ?  82  THR A CA  1 
ATOM 609  C C   . THR A 1 82  ? 64.956  91.480  118.896 1.00 164.74 ?  82  THR A C   1 
ATOM 610  O O   . THR A 1 82  ? 64.602  91.021  117.809 1.00 164.92 ?  82  THR A O   1 
ATOM 611  C CB  . THR A 1 82  ? 66.508  90.186  120.370 1.00 168.44 ?  82  THR A CB  1 
ATOM 612  O OG1 . THR A 1 82  ? 67.856  90.113  120.847 1.00 167.42 ?  82  THR A OG1 1 
ATOM 613  C CG2 . THR A 1 82  ? 66.139  88.861  119.724 1.00 164.36 ?  82  THR A CG2 1 
ATOM 614  N N   . SER A 1 83  ? 64.135  92.147  119.691 1.00 175.14 ?  83  SER A N   1 
ATOM 615  C CA  . SER A 1 83  ? 62.730  92.287  119.351 1.00 176.44 ?  83  SER A CA  1 
ATOM 616  C C   . SER A 1 83  ? 62.419  93.762  119.371 1.00 178.83 ?  83  SER A C   1 
ATOM 617  O O   . SER A 1 83  ? 63.111  94.526  120.035 1.00 178.04 ?  83  SER A O   1 
ATOM 618  C CB  . SER A 1 83  ? 61.871  91.560  120.380 1.00 175.63 ?  83  SER A CB  1 
ATOM 619  O OG  . SER A 1 83  ? 61.992  92.159  121.656 1.00 175.45 ?  83  SER A OG  1 
ATOM 620  N N   . PRO A 1 84  ? 61.382  94.212  118.628 1.00 187.08 ?  84  PRO A N   1 
ATOM 621  C CA  . PRO A 1 84  ? 61.192  95.671  118.621 1.00 186.82 ?  84  PRO A CA  1 
ATOM 622  C C   . PRO A 1 84  ? 60.765  96.236  119.975 1.00 185.96 ?  84  PRO A C   1 
ATOM 623  O O   . PRO A 1 84  ? 59.700  95.858  120.466 1.00 183.32 ?  84  PRO A O   1 
ATOM 624  C CB  . PRO A 1 84  ? 60.095  95.894  117.577 1.00 186.04 ?  84  PRO A CB  1 
ATOM 625  C CG  . PRO A 1 84  ? 59.391  94.598  117.439 1.00 185.09 ?  84  PRO A CG  1 
ATOM 626  C CD  . PRO A 1 84  ? 60.301  93.505  117.913 1.00 183.88 ?  84  PRO A CD  1 
ATOM 627  N N   . GLN A 1 85  ? 61.569  97.119  120.560 1.00 190.37 ?  85  GLN A N   1 
ATOM 628  C CA  . GLN A 1 85  ? 61.242  97.730  121.851 1.00 190.49 ?  85  GLN A CA  1 
ATOM 629  C C   . GLN A 1 85  ? 60.572  99.101  121.661 1.00 189.29 ?  85  GLN A C   1 
ATOM 630  O O   . GLN A 1 85  ? 61.195  99.992  121.085 1.00 188.37 ?  85  GLN A O   1 
ATOM 631  C CB  . GLN A 1 85  ? 62.514  97.867  122.695 1.00 189.56 ?  85  GLN A CB  1 
ATOM 632  C CG  . GLN A 1 85  ? 62.325  98.595  124.021 1.00 189.73 ?  85  GLN A CG  1 
ATOM 633  C CD  . GLN A 1 85  ? 63.574  98.583  124.887 1.00 190.45 ?  85  GLN A CD  1 
ATOM 634  O OE1 . GLN A 1 85  ? 64.322  97.608  124.904 1.00 190.65 ?  85  GLN A OE1 1 
ATOM 635  N NE2 . GLN A 1 85  ? 63.794  99.663  125.628 1.00 189.45 ?  85  GLN A NE2 1 
ATOM 636  N N   . TRP A 1 86  ? 59.337  99.283  122.160 1.00 195.32 ?  86  TRP A N   1 
ATOM 637  C CA  . TRP A 1 86  ? 58.629  100.552 122.020 1.00 196.29 ?  86  TRP A CA  1 
ATOM 638  C C   . TRP A 1 86  ? 58.713  101.362 123.301 1.00 196.49 ?  86  TRP A C   1 
ATOM 639  O O   . TRP A 1 86  ? 58.457  100.835 124.383 1.00 195.40 ?  86  TRP A O   1 
ATOM 640  C CB  . TRP A 1 86  ? 57.170  100.298 121.646 1.00 195.41 ?  86  TRP A CB  1 
ATOM 641  C CG  . TRP A 1 86  ? 57.017  99.318  120.521 1.00 195.33 ?  86  TRP A CG  1 
ATOM 642  C CD1 . TRP A 1 86  ? 56.940  97.957  120.619 1.00 194.81 ?  86  TRP A CD1 1 
ATOM 643  C CD2 . TRP A 1 86  ? 56.930  99.623  119.126 1.00 196.55 ?  86  TRP A CD2 1 
ATOM 644  N NE1 . TRP A 1 86  ? 56.811  97.399  119.373 1.00 196.85 ?  86  TRP A NE1 1 
ATOM 645  C CE2 . TRP A 1 86  ? 56.801  98.400  118.438 1.00 197.21 ?  86  TRP A CE2 1 
ATOM 646  C CE3 . TRP A 1 86  ? 56.946  100.811 118.391 1.00 195.33 ?  86  TRP A CE3 1 
ATOM 647  C CZ2 . TRP A 1 86  ? 56.689  98.333  117.054 1.00 195.62 ?  86  TRP A CZ2 1 
ATOM 648  C CZ3 . TRP A 1 86  ? 56.835  100.741 117.018 1.00 195.19 ?  86  TRP A CZ3 1 
ATOM 649  C CH2 . TRP A 1 86  ? 56.706  99.512  116.364 1.00 194.69 ?  86  TRP A CH2 1 
ATOM 650  N N   . GLY A 1 87  ? 59.070  102.639 123.189 1.00 202.15 ?  87  GLY A N   1 
ATOM 651  C CA  . GLY A 1 87  ? 59.201  103.490 124.357 1.00 200.95 ?  87  GLY A CA  1 
ATOM 652  C C   . GLY A 1 87  ? 60.452  103.155 125.147 1.00 201.65 ?  87  GLY A C   1 
ATOM 653  O O   . GLY A 1 87  ? 60.381  102.583 126.235 1.00 201.80 ?  87  GLY A O   1 
ATOM 654  N N   . THR A 1 99  ? 65.998  97.128  129.284 1.00 195.57 ?  99  THR A N   1 
ATOM 655  C CA  . THR A 1 99  ? 66.348  95.759  129.641 1.00 195.04 ?  99  THR A CA  1 
ATOM 656  C C   . THR A 1 99  ? 66.136  94.836  128.461 1.00 193.28 ?  99  THR A C   1 
ATOM 657  O O   . THR A 1 99  ? 66.188  93.617  128.608 1.00 192.05 ?  99  THR A O   1 
ATOM 658  C CB  . THR A 1 99  ? 65.499  95.244  130.818 1.00 193.84 ?  99  THR A CB  1 
ATOM 659  O OG1 . THR A 1 99  ? 64.124  95.164  130.421 1.00 193.39 ?  99  THR A OG1 1 
ATOM 660  C CG2 . THR A 1 99  ? 65.626  96.172  132.014 1.00 192.19 ?  99  THR A CG2 1 
ATOM 661  N N   . GLY A 1 100 ? 65.894  95.409  127.289 1.00 177.07 ?  100 GLY A N   1 
ATOM 662  C CA  . GLY A 1 100 ? 65.641  94.605  126.108 1.00 176.53 ?  100 GLY A CA  1 
ATOM 663  C C   . GLY A 1 100 ? 66.831  93.781  125.682 1.00 177.69 ?  100 GLY A C   1 
ATOM 664  O O   . GLY A 1 100 ? 67.973  94.224  125.794 1.00 176.20 ?  100 GLY A O   1 
ATOM 665  N N   . ALA A 1 101 ? 66.570  92.578  125.189 1.00 158.96 ?  101 ALA A N   1 
ATOM 666  C CA  . ALA A 1 101 ? 67.648  91.708  124.752 1.00 156.74 ?  101 ALA A CA  1 
ATOM 667  C C   . ALA A 1 101 ? 68.379  92.324  123.583 1.00 155.12 ?  101 ALA A C   1 
ATOM 668  O O   . ALA A 1 101 ? 67.764  92.881  122.684 1.00 155.23 ?  101 ALA A O   1 
ATOM 669  C CB  . ALA A 1 101 ? 67.102  90.345  124.370 1.00 154.88 ?  101 ALA A CB  1 
ATOM 670  N N   . THR A 1 102 ? 69.698  92.216  123.589 1.00 151.62 ?  102 THR A N   1 
ATOM 671  C CA  . THR A 1 102 ? 70.484  92.782  122.515 1.00 152.50 ?  102 THR A CA  1 
ATOM 672  C C   . THR A 1 102 ? 71.247  91.712  121.763 1.00 153.42 ?  102 THR A C   1 
ATOM 673  O O   . THR A 1 102 ? 71.961  90.920  122.365 1.00 155.29 ?  102 THR A O   1 
ATOM 674  C CB  . THR A 1 102 ? 71.477  93.825  123.045 1.00 152.81 ?  102 THR A CB  1 
ATOM 675  O OG1 . THR A 1 102 ? 72.254  93.249  124.101 1.00 153.79 ?  102 THR A OG1 1 
ATOM 676  C CG2 . THR A 1 102 ? 70.744  95.041  123.577 1.00 151.37 ?  102 THR A CG2 1 
ATOM 677  N N   . GLU A 1 103 ? 71.092  91.647  120.442 1.00 150.77 ?  103 GLU A N   1 
ATOM 678  C CA  . GLU A 1 103 ? 71.776  90.648  119.639 1.00 148.15 ?  103 GLU A CA  1 
ATOM 679  C C   . GLU A 1 103 ? 72.900  91.340  118.902 1.00 151.33 ?  103 GLU A C   1 
ATOM 680  O O   . GLU A 1 103 ? 72.794  92.523  118.608 1.00 152.39 ?  103 GLU A O   1 
ATOM 681  C CB  . GLU A 1 103 ? 70.811  89.962  118.664 1.00 145.70 ?  103 GLU A CB  1 
ATOM 682  C CG  . GLU A 1 103 ? 70.110  90.845  117.636 1.00 148.11 ?  103 GLU A CG  1 
ATOM 683  C CD  . GLU A 1 103 ? 69.243  90.063  116.663 1.00 150.50 ?  103 GLU A CD  1 
ATOM 684  O OE1 . GLU A 1 103 ? 69.473  88.851  116.473 1.00 150.29 ?  103 GLU A OE1 1 
ATOM 685  O OE2 . GLU A 1 103 ? 68.327  90.672  116.072 1.00 151.43 -1 103 GLU A OE2 1 
ATOM 686  N N   . PRO A 1 104 ? 73.999  90.600  118.643 1.00 146.59 ?  104 PRO A N   1 
ATOM 687  C CA  . PRO A 1 104 ? 75.038  91.214  117.824 1.00 143.85 ?  104 PRO A CA  1 
ATOM 688  C C   . PRO A 1 104 ? 74.393  91.485  116.497 1.00 142.43 ?  104 PRO A C   1 
ATOM 689  O O   . PRO A 1 104 ? 73.360  90.888  116.186 1.00 136.74 ?  104 PRO A O   1 
ATOM 690  C CB  . PRO A 1 104 ? 76.094  90.116  117.701 1.00 137.61 ?  104 PRO A CB  1 
ATOM 691  C CG  . PRO A 1 104 ? 75.371  88.845  117.996 1.00 142.63 ?  104 PRO A CG  1 
ATOM 692  C CD  . PRO A 1 104 ? 74.356  89.222  119.029 1.00 143.49 ?  104 PRO A CD  1 
ATOM 693  N N   . CYS A 1 105 ? 74.964  92.347  115.679 1.00 143.70 ?  105 CYS A N   1 
ATOM 694  C CA  . CYS A 1 105 ? 74.258  92.699  114.450 1.00 142.25 ?  105 CYS A CA  1 
ATOM 695  C C   . CYS A 1 105 ? 74.646  91.866  113.244 1.00 142.93 ?  105 CYS A C   1 
ATOM 696  O O   . CYS A 1 105 ? 75.739  92.010  112.697 1.00 140.07 ?  105 CYS A O   1 
ATOM 697  C CB  . CYS A 1 105 ? 74.444  94.183  114.205 1.00 139.39 ?  105 CYS A CB  1 
ATOM 698  S SG  . CYS A 1 105 ? 74.073  95.009  115.760 1.00 144.97 ?  105 CYS A SG  1 
ATOM 699  N N   . THR A 1 106 ? 73.735  90.992  112.833 1.00 149.62 ?  106 THR A N   1 
ATOM 700  C CA  . THR A 1 106 ? 74.001  90.132  111.693 1.00 148.73 ?  106 THR A CA  1 
ATOM 701  C C   . THR A 1 106 ? 73.814  90.881  110.389 1.00 145.02 ?  106 THR A C   1 
ATOM 702  O O   . THR A 1 106 ? 74.553  90.654  109.432 1.00 142.61 ?  106 THR A O   1 
ATOM 703  C CB  . THR A 1 106 ? 73.065  88.914  111.694 1.00 147.62 ?  106 THR A CB  1 
ATOM 704  O OG1 . THR A 1 106 ? 71.719  89.343  111.453 1.00 147.46 ?  106 THR A OG1 1 
ATOM 705  C CG2 . THR A 1 106 ? 73.131  88.197  113.033 1.00 143.74 ?  106 THR A CG2 1 
ATOM 706  N N   . ASP A 1 107 ? 72.830  91.774  110.335 1.00 136.84 ?  107 ASP A N   1 
ATOM 707  C CA  . ASP A 1 107 ? 72.556  92.446  109.057 1.00 133.01 ?  107 ASP A CA  1 
ATOM 708  C C   . ASP A 1 107 ? 73.485  93.597  108.687 1.00 134.19 ?  107 ASP A C   1 
ATOM 709  O O   . ASP A 1 107 ? 73.176  94.329  107.757 1.00 137.90 ?  107 ASP A O   1 
ATOM 710  C CB  . ASP A 1 107 ? 71.094  92.900  109.004 1.00 133.74 ?  107 ASP A CB  1 
ATOM 711  C CG  . ASP A 1 107 ? 70.109  91.735  109.028 1.00 138.79 ?  107 ASP A CG  1 
ATOM 712  O OD1 . ASP A 1 107 ? 68.894  91.995  108.942 1.00 139.54 ?  107 ASP A OD1 1 
ATOM 713  O OD2 . ASP A 1 107 ? 70.529  90.563  109.126 1.00 138.99 -1 107 ASP A OD2 1 
ATOM 714  N N   . GLY A 1 108 ? 74.613  93.765  109.372 1.00 126.52 ?  108 GLY A N   1 
ATOM 715  C CA  . GLY A 1 108 ? 75.572  94.777  108.994 1.00 124.27 ?  108 GLY A CA  1 
ATOM 716  C C   . GLY A 1 108 ? 75.399  96.094  109.693 1.00 122.20 ?  108 GLY A C   1 
ATOM 717  O O   . GLY A 1 108 ? 74.596  96.203  110.606 1.00 127.42 ?  108 GLY A O   1 
ATOM 718  N N   . TRP A 1 109 ? 76.149  97.101  109.273 1.00 111.02 ?  109 TRP A N   1 
ATOM 719  C CA  . TRP A 1 109 ? 76.111  98.378  109.956 1.00 117.16 ?  109 TRP A CA  1 
ATOM 720  C C   . TRP A 1 109 ? 75.801  99.513  109.009 1.00 121.08 ?  109 TRP A C   1 
ATOM 721  O O   . TRP A 1 109 ? 76.099  99.422  107.828 1.00 128.11 ?  109 TRP A O   1 
ATOM 722  C CB  . TRP A 1 109 ? 77.470  98.656  110.590 1.00 116.07 ?  109 TRP A CB  1 
ATOM 723  C CG  . TRP A 1 109 ? 77.827  97.811  111.760 1.00 118.60 ?  109 TRP A CG  1 
ATOM 724  C CD1 . TRP A 1 109 ? 77.667  98.131  113.070 1.00 116.27 ?  109 TRP A CD1 1 
ATOM 725  C CD2 . TRP A 1 109 ? 78.434  96.515  111.734 1.00 122.88 ?  109 TRP A CD2 1 
ATOM 726  N NE1 . TRP A 1 109 ? 78.126  97.113  113.865 1.00 115.67 ?  109 TRP A NE1 1 
ATOM 727  C CE2 . TRP A 1 109 ? 78.602  96.108  113.067 1.00 117.99 ?  109 TRP A CE2 1 
ATOM 728  C CE3 . TRP A 1 109 ? 78.848  95.657  110.712 1.00 124.48 ?  109 TRP A CE3 1 
ATOM 729  C CZ2 . TRP A 1 109 ? 79.160  94.881  113.407 1.00 115.71 ?  109 TRP A CZ2 1 
ATOM 730  C CZ3 . TRP A 1 109 ? 79.400  94.440  111.052 1.00 122.00 ?  109 TRP A CZ3 1 
ATOM 731  C CH2 . TRP A 1 109 ? 79.553  94.064  112.387 1.00 117.02 ?  109 TRP A CH2 1 
ATOM 732  N N   . ILE A 1 110 ? 75.198  100.583 109.511 1.00 103.51 ?  110 ILE A N   1 
ATOM 733  C CA  . ILE A 1 110 ? 74.946  101.750 108.691 1.00 95.73  ?  110 ILE A CA  1 
ATOM 734  C C   . ILE A 1 110 ? 75.943  102.778 109.149 1.00 98.93  ?  110 ILE A C   1 
ATOM 735  O O   . ILE A 1 110 ? 75.958  103.139 110.313 1.00 106.71 ?  110 ILE A O   1 
ATOM 736  C CB  . ILE A 1 110 ? 73.534  102.297 108.895 1.00 95.62  ?  110 ILE A CB  1 
ATOM 737  C CG1 . ILE A 1 110 ? 72.493  101.235 108.571 1.00 101.51 ?  110 ILE A CG1 1 
ATOM 738  C CG2 . ILE A 1 110 ? 73.305  103.523 108.028 1.00 103.88 ?  110 ILE A CG2 1 
ATOM 739  C CD1 . ILE A 1 110 ? 71.072  101.728 108.718 1.00 104.18 ?  110 ILE A CD1 1 
ATOM 740  N N   . TYR A 1 111 ? 76.767  103.277 108.244 1.00 96.87  ?  111 TYR A N   1 
ATOM 741  C CA  . TYR A 1 111 ? 77.822  104.199 108.620 1.00 94.61  ?  111 TYR A CA  1 
ATOM 742  C C   . TYR A 1 111 ? 77.487  105.611 108.192 1.00 102.51 ?  111 TYR A C   1 
ATOM 743  O O   . TYR A 1 111 ? 76.916  105.817 107.128 1.00 102.13 ?  111 TYR A O   1 
ATOM 744  C CB  . TYR A 1 111 ? 79.131  103.792 107.954 1.00 93.47  ?  111 TYR A CB  1 
ATOM 745  C CG  . TYR A 1 111 ? 79.622  102.396 108.240 1.00 95.78  ?  111 TYR A CG  1 
ATOM 746  C CD1 . TYR A 1 111 ? 80.579  102.168 109.210 1.00 101.76 ?  111 TYR A CD1 1 
ATOM 747  C CD2 . TYR A 1 111 ? 79.160  101.311 107.513 1.00 94.99  ?  111 TYR A CD2 1 
ATOM 748  C CE1 . TYR A 1 111 ? 81.046  100.900 109.466 1.00 95.84  ?  111 TYR A CE1 1 
ATOM 749  C CE2 . TYR A 1 111 ? 79.620  100.038 107.766 1.00 94.64  ?  111 TYR A CE2 1 
ATOM 750  C CZ  . TYR A 1 111 ? 80.562  99.843  108.744 1.00 95.70  ?  111 TYR A CZ  1 
ATOM 751  O OH  . TYR A 1 111 ? 81.023  98.582  108.999 1.00 102.44 ?  111 TYR A OH  1 
ATOM 752  N N   . ASP A 1 112 ? 77.820  106.589 109.019 1.00 116.39 ?  112 ASP A N   1 
ATOM 753  C CA  . ASP A 1 112 ? 77.582  107.973 108.660 1.00 116.48 ?  112 ASP A CA  1 
ATOM 754  C C   . ASP A 1 112 ? 78.426  108.321 107.452 1.00 121.16 ?  112 ASP A C   1 
ATOM 755  O O   . ASP A 1 112 ? 79.616  108.025 107.418 1.00 123.63 ?  112 ASP A O   1 
ATOM 756  C CB  . ASP A 1 112 ? 77.965  108.869 109.830 1.00 117.66 ?  112 ASP A CB  1 
ATOM 757  C CG  . ASP A 1 112 ? 77.530  110.304 109.641 1.00 120.90 ?  112 ASP A CG  1 
ATOM 758  O OD1 . ASP A 1 112 ? 76.663  110.568 108.783 1.00 121.95 ?  112 ASP A OD1 1 
ATOM 759  O OD2 . ASP A 1 112 ? 78.052  111.174 110.367 1.00 119.89 -1 112 ASP A OD2 1 
ATOM 760  N N   . ASN A 1 113 ? 77.832  108.958 106.433 1.00 121.69 ?  113 ASN A N   1 
ATOM 761  C CA  . ASN A 1 113 ? 78.549  109.319 105.206 1.00 121.80 ?  113 ASN A CA  1 
ATOM 762  C C   . ASN A 1 113 ? 78.835  110.804 105.122 1.00 122.75 ?  113 ASN A C   1 
ATOM 763  O O   . ASN A 1 113 ? 79.292  111.287 104.094 1.00 125.92 ?  113 ASN A O   1 
ATOM 764  C CB  . ASN A 1 113 ? 77.721  108.911 103.993 1.00 123.04 ?  113 ASN A CB  1 
ATOM 765  C CG  . ASN A 1 113 ? 77.435  107.421 103.952 1.00 127.20 ?  113 ASN A CG  1 
ATOM 766  O OD1 . ASN A 1 113 ? 78.262  106.606 104.364 1.00 122.66 ?  113 ASN A OD1 1 
ATOM 767  N ND2 . ASN A 1 113 ? 76.269  107.053 103.432 1.00 128.09 ?  113 ASN A ND2 1 
ATOM 768  N N   . SER A 1 114 ? 78.587  111.542 106.194 1.00 122.36 ?  114 SER A N   1 
ATOM 769  C CA  . SER A 1 114 ? 78.771  112.983 106.166 1.00 122.57 ?  114 SER A CA  1 
ATOM 770  C C   . SER A 1 114 ? 80.216  113.363 105.948 1.00 123.40 ?  114 SER A C   1 
ATOM 771  O O   . SER A 1 114 ? 80.517  114.180 105.084 1.00 123.22 ?  114 SER A O   1 
ATOM 772  C CB  . SER A 1 114 ? 78.277  113.593 107.471 1.00 122.21 ?  114 SER A CB  1 
ATOM 773  O OG  . SER A 1 114 ? 78.985  113.065 108.578 1.00 123.54 ?  114 SER A OG  1 
ATOM 774  N N   . THR A 1 115 ? 81.120  112.780 106.718 1.00 118.13 ?  115 THR A N   1 
ATOM 775  C CA  . THR A 1 115 ? 82.529  113.132 106.627 1.00 115.47 ?  115 THR A CA  1 
ATOM 776  C C   . THR A 1 115 ? 83.306  112.168 105.758 1.00 119.58 ?  115 THR A C   1 
ATOM 777  O O   . THR A 1 115 ? 84.071  112.625 104.910 1.00 115.43 ?  115 THR A O   1 
ATOM 778  C CB  . THR A 1 115 ? 83.148  113.102 108.025 1.00 116.29 ?  115 THR A CB  1 
ATOM 779  O OG1 . THR A 1 115 ? 82.989  111.788 108.575 1.00 117.51 ?  115 THR A OG1 1 
ATOM 780  C CG2 . THR A 1 115 ? 82.459  114.106 108.937 1.00 116.59 ?  115 THR A CG2 1 
ATOM 781  N N   . PHE A 1 116 ? 83.107  110.855 105.942 1.00 117.75 ?  116 PHE A N   1 
ATOM 782  C CA  . PHE A 1 116 ? 83.880  109.847 105.225 1.00 108.42 ?  116 PHE A CA  1 
ATOM 783  C C   . PHE A 1 116 ? 82.995  109.012 104.285 1.00 113.87 ?  116 PHE A C   1 
ATOM 784  O O   . PHE A 1 116 ? 82.317  108.104 104.759 1.00 119.93 ?  116 PHE A O   1 
ATOM 785  C CB  . PHE A 1 116 ? 84.596  108.940 106.217 1.00 104.37 ?  116 PHE A CB  1 
ATOM 786  C CG  . PHE A 1 116 ? 85.251  109.679 107.343 1.00 110.72 ?  116 PHE A CG  1 
ATOM 787  C CD1 . PHE A 1 116 ? 86.355  110.476 107.113 1.00 111.26 ?  116 PHE A CD1 1 
ATOM 788  C CD2 . PHE A 1 116 ? 84.760  109.579 108.632 1.00 112.48 ?  116 PHE A CD2 1 
ATOM 789  C CE1 . PHE A 1 116 ? 86.954  111.164 108.146 1.00 107.50 ?  116 PHE A CE1 1 
ATOM 790  C CE2 . PHE A 1 116 ? 85.358  110.260 109.672 1.00 107.40 ?  116 PHE A CE2 1 
ATOM 791  C CZ  . PHE A 1 116 ? 86.458  111.054 109.429 1.00 106.40 ?  116 PHE A CZ  1 
ATOM 792  N N   . PRO A 1 117 ? 83.023  109.288 102.962 1.00 115.22 ?  117 PRO A N   1 
ATOM 793  C CA  . PRO A 1 117 ? 82.187  108.440 102.115 1.00 118.94 ?  117 PRO A CA  1 
ATOM 794  C C   . PRO A 1 117 ? 82.554  106.964 102.246 1.00 123.73 ?  117 PRO A C   1 
ATOM 795  O O   . PRO A 1 117 ? 81.656  106.167 102.509 1.00 120.79 ?  117 PRO A O   1 
ATOM 796  C CB  . PRO A 1 117 ? 82.463  108.952 100.700 1.00 116.71 ?  117 PRO A CB  1 
ATOM 797  C CG  . PRO A 1 117 ? 83.717  109.728 100.767 1.00 115.77 ?  117 PRO A CG  1 
ATOM 798  C CD  . PRO A 1 117 ? 83.872  110.198 102.173 1.00 113.76 ?  117 PRO A CD  1 
ATOM 799  N N   . SER A 1 118 ? 83.824  106.605 102.057 1.00 99.75  ?  118 SER A N   1 
ATOM 800  C CA  . SER A 1 118 ? 84.264  105.232 102.190 1.00 91.24  ?  118 SER A CA  1 
ATOM 801  C C   . SER A 1 118 ? 85.619  105.197 102.818 1.00 88.69  ?  118 SER A C   1 
ATOM 802  O O   . SER A 1 118 ? 86.402  106.115 102.615 1.00 95.40  ?  118 SER A O   1 
ATOM 803  C CB  . SER A 1 118 ? 84.337  104.571 100.832 1.00 99.30  ?  118 SER A CB  1 
ATOM 804  O OG  . SER A 1 118 ? 84.468  103.167 100.953 1.00 105.97 ?  118 SER A OG  1 
ATOM 805  N N   . THR A 1 119 ? 85.912  104.143 103.563 1.00 85.79  ?  119 THR A N   1 
ATOM 806  C CA  . THR A 1 119 ? 87.189  103.975 104.221 1.00 85.08  ?  119 THR A CA  1 
ATOM 807  C C   . THR A 1 119 ? 87.322  102.469 104.205 1.00 94.37  ?  119 THR A C   1 
ATOM 808  O O   . THR A 1 119 ? 86.360  101.802 103.892 1.00 107.11 ?  119 THR A O   1 
ATOM 809  C CB  . THR A 1 119 ? 87.187  104.519 105.644 1.00 81.88  ?  119 THR A CB  1 
ATOM 810  O OG1 . THR A 1 119 ? 86.029  104.048 106.329 1.00 94.53  ?  119 THR A OG1 1 
ATOM 811  C CG2 . THR A 1 119 ? 87.183  106.034 105.648 1.00 91.57  ?  119 THR A CG2 1 
ATOM 812  N N   . ILE A 1 120 ? 88.492  101.921 104.503 1.00 80.73  ?  120 ILE A N   1 
ATOM 813  C CA  . ILE A 1 120 ? 88.654  100.470 104.568 1.00 77.06  ?  120 ILE A CA  1 
ATOM 814  C C   . ILE A 1 120 ? 87.718  99.961  105.639 1.00 82.91  ?  120 ILE A C   1 
ATOM 815  O O   . ILE A 1 120 ? 87.213  98.864  105.528 1.00 97.50  ?  120 ILE A O   1 
ATOM 816  C CB  . ILE A 1 120 ? 90.114  99.981  104.802 1.00 76.87  ?  120 ILE A CB  1 
ATOM 817  C CG1 . ILE A 1 120 ? 90.667  100.400 106.172 1.00 80.62  ?  120 ILE A CG1 1 
ATOM 818  C CG2 . ILE A 1 120 ? 91.019  100.429 103.658 1.00 85.06  ?  120 ILE A CG2 1 
ATOM 819  C CD1 . ILE A 1 120 ? 92.032  99.833  106.498 1.00 75.92  ?  120 ILE A CD1 1 
ATOM 820  N N   . VAL A 1 121 ? 87.508  100.742 106.687 1.00 74.18  ?  121 VAL A N   1 
ATOM 821  C CA  . VAL A 1 121 ? 86.617  100.365 107.784 1.00 71.61  ?  121 VAL A CA  1 
ATOM 822  C C   . VAL A 1 121 ? 85.171  100.177 107.336 1.00 68.09  ?  121 VAL A C   1 
ATOM 823  O O   . VAL A 1 121 ? 84.509  99.252  107.776 1.00 73.39  ?  121 VAL A O   1 
ATOM 824  C CB  . VAL A 1 121 ? 86.712  101.413 108.918 1.00 66.05  ?  121 VAL A CB  1 
ATOM 825  C CG1 . VAL A 1 121 ? 85.581  101.275 109.903 1.00 68.27  ?  121 VAL A CG1 1 
ATOM 826  C CG2 . VAL A 1 121 ? 88.044  101.290 109.639 1.00 73.21  ?  121 VAL A CG2 1 
ATOM 827  N N   . THR A 1 122 ? 84.679  101.040 106.464 1.00 78.54  ?  122 THR A N   1 
ATOM 828  C CA  . THR A 1 122 ? 83.308  100.950 105.967 1.00 84.06  ?  122 THR A CA  1 
ATOM 829  C C   . THR A 1 122 ? 83.198  99.830  104.962 1.00 90.96  ?  122 THR A C   1 
ATOM 830  O O   . THR A 1 122 ? 82.230  99.082  104.972 1.00 99.05  ?  122 THR A O   1 
ATOM 831  C CB  . THR A 1 122 ? 82.902  102.241 105.243 1.00 83.48  ?  122 THR A CB  1 
ATOM 832  O OG1 . THR A 1 122 ? 83.109  103.366 106.094 1.00 85.18  ?  122 THR A OG1 1 
ATOM 833  C CG2 . THR A 1 122 ? 81.451  102.212 104.808 1.00 91.83  ?  122 THR A CG2 1 
ATOM 834  N N   . GLU A 1 123 ? 84.186  99.706  104.090 1.00 96.56  ?  123 GLU A N   1 
ATOM 835  C CA  . GLU A 1 123 ? 84.165  98.691  103.048 1.00 98.82  ?  123 GLU A CA  1 
ATOM 836  C C   . GLU A 1 123 ? 84.158  97.274  103.548 1.00 101.68 ?  123 GLU A C   1 
ATOM 837  O O   . GLU A 1 123 ? 83.377  96.452  103.082 1.00 96.42  ?  123 GLU A O   1 
ATOM 838  C CB  . GLU A 1 123 ? 85.411  98.874  102.185 1.00 92.07  ?  123 GLU A CB  1 
ATOM 839  C CG  . GLU A 1 123 ? 85.498  97.977  100.967 1.00 99.39  ?  123 GLU A CG  1 
ATOM 840  C CD  . GLU A 1 123 ? 84.993  98.657  99.715  1.00 106.91 ?  123 GLU A CD  1 
ATOM 841  O OE1 . GLU A 1 123 ? 84.677  97.944  98.742  1.00 109.10 ?  123 GLU A OE1 1 
ATOM 842  O OE2 . GLU A 1 123 ? 84.912  99.902  99.705  1.00 104.96 -1 123 GLU A OE2 1 
ATOM 843  N N   . TRP A 1 124 ? 85.000  96.978  104.523 1.00 93.00  ?  124 TRP A N   1 
ATOM 844  C CA  . TRP A 1 124 ? 85.134  95.611  104.994 1.00 86.61  ?  124 TRP A CA  1 
ATOM 845  C C   . TRP A 1 124 ? 84.562  95.355  106.357 1.00 89.05  ?  124 TRP A C   1 
ATOM 846  O O   . TRP A 1 124 ? 84.868  94.336  106.956 1.00 106.07 ?  124 TRP A O   1 
ATOM 847  C CB  . TRP A 1 124 ? 86.594  95.185  104.932 1.00 84.49  ?  124 TRP A CB  1 
ATOM 848  C CG  . TRP A 1 124 ? 87.100  95.126  103.534 1.00 87.87  ?  124 TRP A CG  1 
ATOM 849  C CD1 . TRP A 1 124 ? 86.519  94.482  102.486 1.00 90.11  ?  124 TRP A CD1 1 
ATOM 850  C CD2 . TRP A 1 124 ? 88.287  95.735  103.023 1.00 88.69  ?  124 TRP A CD2 1 
ATOM 851  N NE1 . TRP A 1 124 ? 87.267  94.654  101.352 1.00 94.88  ?  124 TRP A NE1 1 
ATOM 852  C CE2 . TRP A 1 124 ? 88.361  95.418  101.656 1.00 90.34  ?  124 TRP A CE2 1 
ATOM 853  C CE3 . TRP A 1 124 ? 89.294  96.515  103.587 1.00 89.71  ?  124 TRP A CE3 1 
ATOM 854  C CZ2 . TRP A 1 124 ? 89.400  95.854  100.848 1.00 90.17  ?  124 TRP A CZ2 1 
ATOM 855  C CZ3 . TRP A 1 124 ? 90.322  96.945  102.783 1.00 92.13  ?  124 TRP A CZ3 1 
ATOM 856  C CH2 . TRP A 1 124 ? 90.369  96.613  101.430 1.00 91.65  ?  124 TRP A CH2 1 
ATOM 857  N N   . ASP A 1 125 ? 83.761  96.279  106.866 1.00 80.49  ?  125 ASP A N   1 
ATOM 858  C CA  . ASP A 1 125 ? 83.132  96.123  108.173 1.00 85.99  ?  125 ASP A CA  1 
ATOM 859  C C   . ASP A 1 125 ? 84.139  95.842  109.255 1.00 90.91  ?  125 ASP A C   1 
ATOM 860  O O   . ASP A 1 125 ? 83.936  94.953  110.070 1.00 89.77  ?  125 ASP A O   1 
ATOM 861  C CB  . ASP A 1 125 ? 82.031  95.069  108.161 1.00 86.17  ?  125 ASP A CB  1 
ATOM 862  C CG  . ASP A 1 125 ? 80.840  95.483  107.333 1.00 96.31  ?  125 ASP A CG  1 
ATOM 863  O OD1 . ASP A 1 125 ? 79.951  94.638  107.110 1.00 96.04  ?  125 ASP A OD1 1 
ATOM 864  O OD2 . ASP A 1 125 ? 80.789  96.652  106.904 1.00 96.78  -1 125 ASP A OD2 1 
ATOM 865  N N   . LEU A 1 126 ? 85.273  96.558  109.237 1.00 84.06  ?  126 LEU A N   1 
ATOM 866  C CA  . LEU A 1 126 ? 86.333  96.375  110.233 1.00 76.91  ?  126 LEU A CA  1 
ATOM 867  C C   . LEU A 1 126 ? 85.849  97.165  111.406 1.00 80.31  ?  126 LEU A C   1 
ATOM 868  O O   . LEU A 1 126 ? 86.436  98.181  111.755 1.00 83.08  ?  126 LEU A O   1 
ATOM 869  C CB  . LEU A 1 126 ? 87.695  96.879  109.721 1.00 74.29  ?  126 LEU A CB  1 
ATOM 870  C CG  . LEU A 1 126 ? 88.249  96.394  108.378 1.00 72.13  ?  126 LEU A CG  1 
ATOM 871  C CD1 . LEU A 1 126 ? 89.580  97.068  108.087 1.00 78.57  ?  126 LEU A CD1 1 
ATOM 872  C CD2 . LEU A 1 126 ? 88.391  94.882  108.325 1.00 73.44  ?  126 LEU A CD2 1 
ATOM 873  N N   . VAL A 1 127 ? 84.794  96.691  112.050 1.00 94.57  ?  127 VAL A N   1 
ATOM 874  C CA  . VAL A 1 127 ? 84.158  97.432  113.109 1.00 95.36  ?  127 VAL A CA  1 
ATOM 875  C C   . VAL A 1 127 ? 83.724  96.432  114.154 1.00 104.40 ?  127 VAL A C   1 
ATOM 876  O O   . VAL A 1 127 ? 83.600  95.253  113.849 1.00 110.85 ?  127 VAL A O   1 
ATOM 877  C CB  . VAL A 1 127 ? 82.987  98.199  112.479 1.00 94.90  ?  127 VAL A CB  1 
ATOM 878  C CG1 . VAL A 1 127 ? 82.118  98.951  113.476 1.00 100.84 ?  127 VAL A CG1 1 
ATOM 879  C CG2 . VAL A 1 127 ? 83.480  99.059  111.343 1.00 88.78  ?  127 VAL A CG2 1 
ATOM 880  N N   . CYS A 1 128 ? 83.524  96.880  115.387 1.00 111.35 ?  128 CYS A N   1 
ATOM 881  C CA  . CYS A 1 128 ? 83.079  95.995  116.459 1.00 107.07 ?  128 CYS A CA  1 
ATOM 882  C C   . CYS A 1 128 ? 84.070  94.864  116.671 1.00 114.30 ?  128 CYS A C   1 
ATOM 883  O O   . CYS A 1 128 ? 85.220  95.144  116.901 1.00 113.07 ?  128 CYS A O   1 
ATOM 884  C CB  . CYS A 1 128 ? 81.629  95.572  116.277 1.00 105.55 ?  128 CYS A CB  1 
ATOM 885  S SG  . CYS A 1 128 ? 80.544  97.001  116.373 1.00 138.37 ?  128 CYS A SG  1 
ATOM 886  N N   . SER A 1 129 ? 83.699  93.599  116.560 1.00 113.80 ?  129 SER A N   1 
ATOM 887  C CA  . SER A 1 129 ? 84.639  92.531  116.895 1.00 114.42 ?  129 SER A CA  1 
ATOM 888  C C   . SER A 1 129 ? 85.922  92.614  116.084 1.00 114.29 ?  129 SER A C   1 
ATOM 889  O O   . SER A 1 129 ? 86.989  92.317  116.612 1.00 108.25 ?  129 SER A O   1 
ATOM 890  C CB  . SER A 1 129 ? 83.984  91.169  116.699 1.00 109.38 ?  129 SER A CB  1 
ATOM 891  O OG  . SER A 1 129 ? 83.169  91.152  115.543 1.00 111.19 ?  129 SER A OG  1 
ATOM 892  N N   . HIS A 1 130 ? 85.833  93.014  114.820 1.00 102.28 ?  130 HIS A N   1 
ATOM 893  C CA  . HIS A 1 130 ? 87.004  93.106  113.952 1.00 93.32  ?  130 HIS A CA  1 
ATOM 894  C C   . HIS A 1 130 ? 87.684  94.481  113.953 1.00 95.10  ?  130 HIS A C   1 
ATOM 895  O O   . HIS A 1 130 ? 88.381  94.811  113.007 1.00 103.61 ?  130 HIS A O   1 
ATOM 896  C CB  . HIS A 1 130 ? 86.598  92.748  112.533 1.00 94.45  ?  130 HIS A CB  1 
ATOM 897  C CG  . HIS A 1 130 ? 85.956  91.407  112.413 1.00 98.71  ?  130 HIS A CG  1 
ATOM 898  N ND1 . HIS A 1 130 ? 84.602  91.246  112.216 1.00 99.84  ?  130 HIS A ND1 1 
ATOM 899  C CD2 . HIS A 1 130 ? 86.481  90.162  112.469 1.00 103.46 ?  130 HIS A CD2 1 
ATOM 900  C CE1 . HIS A 1 130 ? 84.321  89.958  112.151 1.00 103.78 ?  130 HIS A CE1 1 
ATOM 901  N NE2 . HIS A 1 130 ? 85.444  89.278  112.303 1.00 109.05 ?  130 HIS A NE2 1 
ATOM 902  N N   . ARG A 1 131 ? 87.510  95.277  115.002 1.00 97.32  ?  131 ARG A N   1 
ATOM 903  C CA  . ARG A 1 131 ? 88.095  96.618  115.040 1.00 104.28 ?  131 ARG A CA  1 
ATOM 904  C C   . ARG A 1 131 ? 89.601  96.611  115.059 1.00 105.90 ?  131 ARG A C   1 
ATOM 905  O O   . ARG A 1 131 ? 90.232  97.555  114.602 1.00 108.36 ?  131 ARG A O   1 
ATOM 906  C CB  . ARG A 1 131 ? 87.577  97.398  116.249 1.00 101.67 ?  131 ARG A CB  1 
ATOM 907  C CG  . ARG A 1 131 ? 88.093  96.926  117.596 1.00 102.37 ?  131 ARG A CG  1 
ATOM 908  C CD  . ARG A 1 131 ? 87.335  97.588  118.730 1.00 106.88 ?  131 ARG A CD  1 
ATOM 909  N NE  . ARG A 1 131 ? 86.072  96.915  119.005 1.00 112.10 ?  131 ARG A NE  1 
ATOM 910  C CZ  . ARG A 1 131 ? 85.198  97.319  119.918 1.00 111.36 ?  131 ARG A CZ  1 
ATOM 911  N NH1 . ARG A 1 131 ? 85.449  98.401  120.638 1.00 106.97 1  131 ARG A NH1 1 
ATOM 912  N NH2 . ARG A 1 131 ? 84.073  96.646  120.108 1.00 105.18 ?  131 ARG A NH2 1 
ATOM 913  N N   . ALA A 1 132 ? 90.193  95.552  115.608 1.00 101.77 ?  132 ALA A N   1 
ATOM 914  C CA  . ALA A 1 132 ? 91.638  95.473  115.725 1.00 99.25  ?  132 ALA A CA  1 
ATOM 915  C C   . ALA A 1 132 ? 92.291  95.342  114.385 1.00 104.01 ?  132 ALA A C   1 
ATOM 916  O O   . ALA A 1 132 ? 93.464  95.631  114.255 1.00 109.97 ?  132 ALA A O   1 
ATOM 917  C CB  . ALA A 1 132 ? 92.027  94.297  116.592 1.00 94.25  ?  132 ALA A CB  1 
ATOM 918  N N   . LEU A 1 133 ? 91.543  94.906  113.385 1.00 90.75  ?  133 LEU A N   1 
ATOM 919  C CA  . LEU A 1 133 ? 92.089  94.703  112.059 1.00 85.55  ?  133 LEU A CA  1 
ATOM 920  C C   . LEU A 1 133 ? 92.585  96.003  111.467 1.00 91.47  ?  133 LEU A C   1 
ATOM 921  O O   . LEU A 1 133 ? 93.547  96.010  110.732 1.00 106.16 ?  133 LEU A O   1 
ATOM 922  C CB  . LEU A 1 133 ? 91.074  94.012  111.155 1.00 94.74  ?  133 LEU A CB  1 
ATOM 923  C CG  . LEU A 1 133 ? 90.594  92.597  111.513 1.00 93.94  ?  133 LEU A CG  1 
ATOM 924  C CD1 . LEU A 1 133 ? 89.733  92.033  110.394 1.00 92.64  ?  133 LEU A CD1 1 
ATOM 925  C CD2 . LEU A 1 133 ? 91.754  91.657  111.804 1.00 89.58  ?  133 LEU A CD2 1 
ATOM 926  N N   . ARG A 1 134 ? 91.941  97.106  111.785 1.00 82.46  ?  134 ARG A N   1 
ATOM 927  C CA  . ARG A 1 134 ? 92.341  98.395  111.245 1.00 86.04  ?  134 ARG A CA  1 
ATOM 928  C C   . ARG A 1 134 ? 93.769  98.693  111.669 1.00 99.94  ?  134 ARG A C   1 
ATOM 929  O O   . ARG A 1 134 ? 94.549  99.169  110.857 1.00 102.88 ?  134 ARG A O   1 
ATOM 930  C CB  . ARG A 1 134 ? 91.401  99.471  111.771 1.00 85.59  ?  134 ARG A CB  1 
ATOM 931  C CG  . ARG A 1 134 ? 91.459  100.805 111.072 1.00 98.25  ?  134 ARG A CG  1 
ATOM 932  C CD  . ARG A 1 134 ? 90.588  101.790 111.829 1.00 96.01  ?  134 ARG A CD  1 
ATOM 933  N NE  . ARG A 1 134 ? 91.281  102.425 112.949 1.00 98.81  ?  134 ARG A NE  1 
ATOM 934  C CZ  . ARG A 1 134 ? 92.045  103.521 112.883 1.00 99.14  ?  134 ARG A CZ  1 
ATOM 935  N NH1 . ARG A 1 134 ? 92.271  104.158 111.729 1.00 92.50  1  134 ARG A NH1 1 
ATOM 936  N NH2 . ARG A 1 134 ? 92.607  103.988 113.997 1.00 103.70 ?  134 ARG A NH2 1 
ATOM 937  N N   . GLN A 1 135 ? 94.127  98.396  112.919 1.00 99.55  ?  135 GLN A N   1 
ATOM 938  C CA  . GLN A 1 135 ? 95.492  98.616  113.421 1.00 87.02  ?  135 GLN A CA  1 
ATOM 939  C C   . GLN A 1 135 ? 96.443  97.533  112.947 1.00 89.62  ?  135 GLN A C   1 
ATOM 940  O O   . GLN A 1 135 ? 97.605  97.821  112.753 1.00 101.35 ?  135 GLN A O   1 
ATOM 941  C CB  . GLN A 1 135 ? 95.539  98.663  114.942 1.00 85.17  ?  135 GLN A CB  1 
ATOM 942  C CG  . GLN A 1 135 ? 94.975  99.917  115.597 1.00 88.03  ?  135 GLN A CG  1 
ATOM 943  C CD  . GLN A 1 135 ? 93.481  99.868  115.866 1.00 99.18  ?  135 GLN A CD  1 
ATOM 944  O OE1 . GLN A 1 135 ? 92.857  98.812  115.828 1.00 98.40  ?  135 GLN A OE1 1 
ATOM 945  N NE2 . GLN A 1 135 ? 92.904  101.023 116.162 1.00 96.97  ?  135 GLN A NE2 1 
ATOM 946  N N   . LEU A 1 136 ? 95.988  96.292  112.793 1.00 81.79  ?  136 LEU A N   1 
ATOM 947  C CA  . LEU A 1 136 ? 96.826  95.226  112.239 1.00 86.07  ?  136 LEU A CA  1 
ATOM 948  C C   . LEU A 1 136 ? 97.364  95.618  110.885 1.00 87.35  ?  136 LEU A C   1 
ATOM 949  O O   . LEU A 1 136 ? 98.501  95.320  110.573 1.00 91.58  ?  136 LEU A O   1 
ATOM 950  C CB  . LEU A 1 136 ? 96.061  93.915  112.106 1.00 89.50  ?  136 LEU A CB  1 
ATOM 951  C CG  . LEU A 1 136 ? 96.836  92.699  111.605 1.00 83.73  ?  136 LEU A CG  1 
ATOM 952  C CD1 . LEU A 1 136 ? 97.861  92.266  112.639 1.00 84.40  ?  136 LEU A CD1 1 
ATOM 953  C CD2 . LEU A 1 136 ? 95.882  91.564  111.287 1.00 89.59  ?  136 LEU A CD2 1 
ATOM 954  N N   . ALA A 1 137 ? 96.564  96.295  110.077 1.00 85.14  ?  137 ALA A N   1 
ATOM 955  C CA  . ALA A 1 137 ? 97.021  96.751  108.777 1.00 80.78  ?  137 ALA A CA  1 
ATOM 956  C C   . ALA A 1 137 ? 98.129  97.785  108.861 1.00 86.58  ?  137 ALA A C   1 
ATOM 957  O O   . ALA A 1 137 ? 99.050  97.741  108.058 1.00 95.26  ?  137 ALA A O   1 
ATOM 958  C CB  . ALA A 1 137 ? 95.866  97.273  107.965 1.00 78.14  ?  137 ALA A CB  1 
ATOM 959  N N   . GLN A 1 138 ? 98.054  98.729  109.793 1.00 85.44  ?  138 GLN A N   1 
ATOM 960  C CA  . GLN A 1 138 ? 99.157  99.677  109.978 1.00 83.56  ?  138 GLN A CA  1 
ATOM 961  C C   . GLN A 1 138 ? 100.410 98.963  110.447 1.00 87.22  ?  138 GLN A C   1 
ATOM 962  O O   . GLN A 1 138 ? 101.496 99.242  109.969 1.00 89.36  ?  138 GLN A O   1 
ATOM 963  C CB  . GLN A 1 138 ? 98.781  100.787 110.954 1.00 85.73  ?  138 GLN A CB  1 
ATOM 964  C CG  . GLN A 1 138 ? 99.850  101.843 111.171 1.00 88.68  ?  138 GLN A CG  1 
ATOM 965  C CD  . GLN A 1 138 ? 100.088 102.705 109.951 1.00 95.99  ?  138 GLN A CD  1 
ATOM 966  O OE1 . GLN A 1 138 ? 99.479  102.507 108.905 1.00 90.65  ?  138 GLN A OE1 1 
ATOM 967  N NE2 . GLN A 1 138 ? 100.980 103.672 110.081 1.00 100.90 ?  138 GLN A NE2 1 
ATOM 968  N N   . SER A 1 139 ? 100.267 98.018  111.362 1.00 80.41  ?  139 SER A N   1 
ATOM 969  C CA  . SER A 1 139 ? 101.404 97.266  111.843 1.00 75.39  ?  139 SER A CA  1 
ATOM 970  C C   . SER A 1 139 ? 102.027 96.471  110.727 1.00 87.25  ?  139 SER A C   1 
ATOM 971  O O   . SER A 1 139 ? 103.234 96.402  110.644 1.00 101.20 ?  139 SER A O   1 
ATOM 972  C CB  . SER A 1 139 ? 100.982 96.342  112.962 1.00 86.10  ?  139 SER A CB  1 
ATOM 973  O OG  . SER A 1 139 ? 102.087 95.617  113.458 1.00 97.47  ?  139 SER A OG  1 
ATOM 974  N N   . LEU A 1 140 ? 101.225 95.862  109.864 1.00 90.31  ?  140 LEU A N   1 
ATOM 975  C CA  . LEU A 1 140 ? 101.749 95.132  108.706 1.00 93.07  ?  140 LEU A CA  1 
ATOM 976  C C   . LEU A 1 140 ? 102.469 96.026  107.706 1.00 92.59  ?  140 LEU A C   1 
ATOM 977  O O   . LEU A 1 140 ? 103.482 95.630  107.153 1.00 98.36  ?  140 LEU A O   1 
ATOM 978  C CB  . LEU A 1 140 ? 100.680 94.275  108.035 1.00 85.59  ?  140 LEU A CB  1 
ATOM 979  C CG  . LEU A 1 140 ? 100.332 92.998  108.793 1.00 89.63  ?  140 LEU A CG  1 
ATOM 980  C CD1 . LEU A 1 140 ? 99.320  92.181  108.013 1.00 88.08  ?  140 LEU A CD1 1 
ATOM 981  C CD2 . LEU A 1 140 ? 101.588 92.185  109.049 1.00 89.31  ?  140 LEU A CD2 1 
ATOM 982  N N   . TYR A 1 141 ? 101.971 97.230  107.470 1.00 76.81  ?  141 TYR A N   1 
ATOM 983  C CA  . TYR A 1 141 ? 102.668 98.140  106.591 1.00 71.02  ?  141 TYR A CA  1 
ATOM 984  C C   . TYR A 1 141 ? 104.012 98.404  107.193 1.00 81.42  ?  141 TYR A C   1 
ATOM 985  O O   . TYR A 1 141 ? 105.012 98.382  106.494 1.00 96.64  ?  141 TYR A O   1 
ATOM 986  C CB  . TYR A 1 141 ? 101.907 99.448  106.501 1.00 84.51  ?  141 TYR A CB  1 
ATOM 987  C CG  . TYR A 1 141 ? 102.643 100.560 105.807 1.00 83.51  ?  141 TYR A CG  1 
ATOM 988  C CD1 . TYR A 1 141 ? 102.669 100.637 104.430 1.00 88.13  ?  141 TYR A CD1 1 
ATOM 989  C CD2 . TYR A 1 141 ? 103.298 101.543 106.529 1.00 78.95  ?  141 TYR A CD2 1 
ATOM 990  C CE1 . TYR A 1 141 ? 103.336 101.652 103.787 1.00 86.81  ?  141 TYR A CE1 1 
ATOM 991  C CE2 . TYR A 1 141 ? 103.974 102.558 105.894 1.00 79.35  ?  141 TYR A CE2 1 
ATOM 992  C CZ  . TYR A 1 141 ? 103.987 102.604 104.523 1.00 84.19  ?  141 TYR A CZ  1 
ATOM 993  O OH  . TYR A 1 141 ? 104.654 103.607 103.879 1.00 95.16  ?  141 TYR A OH  1 
ATOM 994  N N   . MET A 1 142 ? 104.082 98.615  108.507 1.00 84.25  ?  142 MET A N   1 
ATOM 995  C CA  . MET A 1 142 ? 105.349 98.925  109.170 1.00 83.13  ?  142 MET A CA  1 
ATOM 996  C C   . MET A 1 142 ? 106.259 97.709  109.275 1.00 83.34  ?  142 MET A C   1 
ATOM 997  O O   . MET A 1 142 ? 107.465 97.873  109.368 1.00 92.41  ?  142 MET A O   1 
ATOM 998  C CB  . MET A 1 142 ? 105.109 99.560  110.535 1.00 89.22  ?  142 MET A CB  1 
ATOM 999  C CG  . MET A 1 142 ? 104.425 100.922 110.503 1.00 95.64  ?  142 MET A CG  1 
ATOM 1000 S SD  . MET A 1 142 ? 105.466 102.232 109.836 1.00 97.50  ?  142 MET A SD  1 
ATOM 1001 C CE  . MET A 1 142 ? 104.320 103.601 109.791 1.00 78.87  ?  142 MET A CE  1 
ATOM 1002 N N   . VAL A 1 143 ? 105.714 96.498  109.299 1.00 82.10  ?  143 VAL A N   1 
ATOM 1003 C CA  . VAL A 1 143 ? 106.539 95.288  109.262 1.00 79.56  ?  143 VAL A CA  1 
ATOM 1004 C C   . VAL A 1 143 ? 107.209 95.332  107.927 1.00 84.85  ?  143 VAL A C   1 
ATOM 1005 O O   . VAL A 1 143 ? 108.357 94.974  107.811 1.00 89.73  ?  143 VAL A O   1 
ATOM 1006 C CB  . VAL A 1 143 ? 105.733 93.990  109.406 1.00 75.98  ?  143 VAL A CB  1 
ATOM 1007 C CG1 . VAL A 1 143 ? 106.520 92.778  108.924 1.00 74.99  ?  143 VAL A CG1 1 
ATOM 1008 C CG2 . VAL A 1 143 ? 105.299 93.792  110.846 1.00 90.39  ?  143 VAL A CG2 1 
ATOM 1009 N N   . GLY A 1 144 ? 106.489 95.760  106.904 1.00 93.50  ?  144 GLY A N   1 
ATOM 1010 C CA  . GLY A 1 144 ? 107.065 95.914  105.589 1.00 92.63  ?  144 GLY A CA  1 
ATOM 1011 C C   . GLY A 1 144 ? 108.156 96.938  105.565 1.00 86.41  ?  144 GLY A C   1 
ATOM 1012 O O   . GLY A 1 144 ? 109.138 96.713  104.924 1.00 96.65  ?  144 GLY A O   1 
ATOM 1013 N N   . VAL A 1 145 ? 107.995 98.050  106.267 1.00 75.48  ?  145 VAL A N   1 
ATOM 1014 C CA  . VAL A 1 145 ? 109.030 99.081  106.340 1.00 78.65  ?  145 VAL A CA  1 
ATOM 1015 C C   . VAL A 1 145 ? 110.304 98.550  107.010 1.00 78.36  ?  145 VAL A C   1 
ATOM 1016 O O   . VAL A 1 145 ? 111.392 98.848  106.555 1.00 88.81  ?  145 VAL A O   1 
ATOM 1017 C CB  . VAL A 1 145 ? 108.517 100.382 107.020 1.00 79.07  ?  145 VAL A CB  1 
ATOM 1018 C CG1 . VAL A 1 145 ? 109.620 101.421 107.167 1.00 75.56  ?  145 VAL A CG1 1 
ATOM 1019 C CG2 . VAL A 1 145 ? 107.358 100.994 106.234 1.00 90.77  ?  145 VAL A CG2 1 
ATOM 1020 N N   . LEU A 1 146 ? 110.185 97.761  108.071 1.00 83.11  ?  146 LEU A N   1 
ATOM 1021 C CA  . LEU A 1 146 ? 111.355 97.152  108.727 1.00 86.09  ?  146 LEU A CA  1 
ATOM 1022 C C   . LEU A 1 146 ? 112.022 96.167  107.787 1.00 93.66  ?  146 LEU A C   1 
ATOM 1023 O O   . LEU A 1 146 ? 113.235 96.184  107.654 1.00 100.78 ?  146 LEU A O   1 
ATOM 1024 C CB  . LEU A 1 146 ? 110.940 96.439  110.013 1.00 92.73  ?  146 LEU A CB  1 
ATOM 1025 C CG  . LEU A 1 146 ? 112.008 95.843  110.935 1.00 88.78  ?  146 LEU A CG  1 
ATOM 1026 C CD1 . LEU A 1 146 ? 112.510 96.882  111.923 1.00 95.13  ?  146 LEU A CD1 1 
ATOM 1027 C CD2 . LEU A 1 146 ? 111.467 94.637  111.687 1.00 85.77  ?  146 LEU A CD2 1 
ATOM 1028 N N   . LEU A 1 147 ? 111.249 95.309  107.133 1.00 92.80  ?  147 LEU A N   1 
ATOM 1029 C CA  . LEU A 1 147 ? 111.782 94.341  106.182 1.00 87.19  ?  147 LEU A CA  1 
ATOM 1030 C C   . LEU A 1 147 ? 112.449 95.014  105.019 1.00 91.73  ?  147 LEU A C   1 
ATOM 1031 O O   . LEU A 1 147 ? 113.442 94.535  104.548 1.00 91.53  ?  147 LEU A O   1 
ATOM 1032 C CB  . LEU A 1 147 ? 110.688 93.438  105.627 1.00 87.10  ?  147 LEU A CB  1 
ATOM 1033 C CG  . LEU A 1 147 ? 110.031 92.396  106.532 1.00 102.32 ?  147 LEU A CG  1 
ATOM 1034 C CD1 . LEU A 1 147 ? 108.708 91.947  105.927 1.00 97.66  ?  147 LEU A CD1 1 
ATOM 1035 C CD2 . LEU A 1 147 ? 110.956 91.213  106.768 1.00 99.54  ?  147 LEU A CD2 1 
ATOM 1036 N N   . GLY A 1 148 ? 111.890 96.102  104.526 1.00 98.23  ?  148 GLY A N   1 
ATOM 1037 C CA  . GLY A 1 148 ? 112.436 96.782  103.372 1.00 91.53  ?  148 GLY A CA  1 
ATOM 1038 C C   . GLY A 1 148 ? 113.705 97.514  103.662 1.00 84.76  ?  148 GLY A C   1 
ATOM 1039 O O   . GLY A 1 148 ? 114.563 97.575  102.813 1.00 96.78  ?  148 GLY A O   1 
ATOM 1040 N N   . ALA A 1 149 ? 113.843 98.083  104.845 1.00 83.33  ?  149 ALA A N   1 
ATOM 1041 C CA  . ALA A 1 149 ? 115.090 98.713  105.178 1.00 87.90  ?  149 ALA A CA  1 
ATOM 1042 C C   . ALA A 1 149 ? 116.197 97.682  105.088 1.00 89.57  ?  149 ALA A C   1 
ATOM 1043 O O   . ALA A 1 149 ? 117.284 98.009  104.625 1.00 94.88  ?  149 ALA A O   1 
ATOM 1044 C CB  . ALA A 1 149 ? 115.031 99.300  106.560 1.00 94.08  ?  149 ALA A CB  1 
ATOM 1045 N N   . MET A 1 150 ? 115.938 96.445  105.517 1.00 94.82  ?  150 MET A N   1 
ATOM 1046 C CA  . MET A 1 150 ? 116.960 95.418  105.514 1.00 89.90  ?  150 MET A CA  1 
ATOM 1047 C C   . MET A 1 150 ? 117.212 94.761  104.155 1.00 93.88  ?  150 MET A C   1 
ATOM 1048 O O   . MET A 1 150 ? 118.355 94.666  103.722 1.00 99.70  ?  150 MET A O   1 
ATOM 1049 C CB  . MET A 1 150 ? 116.598 94.356  106.542 1.00 95.13  ?  150 MET A CB  1 
ATOM 1050 C CG  . MET A 1 150 ? 116.492 94.879  107.960 1.00 100.45 ?  150 MET A CG  1 
ATOM 1051 S SD  . MET A 1 150 ? 115.566 93.742  109.002 1.00 116.54 ?  150 MET A SD  1 
ATOM 1052 C CE  . MET A 1 150 ? 116.260 92.177  108.481 1.00 94.70  ?  150 MET A CE  1 
ATOM 1053 N N   . VAL A 1 151 ? 116.141 94.343  103.475 1.00 98.41  ?  151 VAL A N   1 
ATOM 1054 C CA  . VAL A 1 151 ? 116.267 93.694  102.176 1.00 97.08  ?  151 VAL A CA  1 
ATOM 1055 C C   . VAL A 1 151 ? 116.884 94.664  101.206 1.00 101.66 ?  151 VAL A C   1 
ATOM 1056 O O   . VAL A 1 151 ? 117.902 94.362  100.641 1.00 104.27 ?  151 VAL A O   1 
ATOM 1057 C CB  . VAL A 1 151 ? 114.914 93.195  101.626 1.00 93.39  ?  151 VAL A CB  1 
ATOM 1058 C CG1 . VAL A 1 151 ? 115.020 92.818  100.155 1.00 95.74  ?  151 VAL A CG1 1 
ATOM 1059 C CG2 . VAL A 1 151 ? 114.406 92.009  102.434 1.00 100.12 ?  151 VAL A CG2 1 
ATOM 1060 N N   . PHE A 1 152 ? 116.282 95.832  101.021 1.00 99.68  ?  152 PHE A N   1 
ATOM 1061 C CA  . PHE A 1 152 ? 116.789 96.819  100.066 1.00 88.42  ?  152 PHE A CA  1 
ATOM 1062 C C   . PHE A 1 152 ? 118.118 97.427  100.437 1.00 91.98  ?  152 PHE A C   1 
ATOM 1063 O O   . PHE A 1 152 ? 118.808 97.915  99.566  1.00 99.27  ?  152 PHE A O   1 
ATOM 1064 C CB  . PHE A 1 152 ? 115.741 97.866  99.696  1.00 83.39  ?  152 PHE A CB  1 
ATOM 1065 C CG  . PHE A 1 152 ? 114.601 97.295  98.908  1.00 91.38  ?  152 PHE A CG  1 
ATOM 1066 C CD1 . PHE A 1 152 ? 114.840 96.660  97.701  1.00 95.67  ?  152 PHE A CD1 1 
ATOM 1067 C CD2 . PHE A 1 152 ? 113.306 97.363  99.371  1.00 94.27  ?  152 PHE A CD2 1 
ATOM 1068 C CE1 . PHE A 1 152 ? 113.818 96.113  96.973  1.00 91.11  ?  152 PHE A CE1 1 
ATOM 1069 C CE2 . PHE A 1 152 ? 112.274 96.820  98.638  1.00 95.69  ?  152 PHE A CE2 1 
ATOM 1070 C CZ  . PHE A 1 152 ? 112.533 96.195  97.441  1.00 90.87  ?  152 PHE A CZ  1 
ATOM 1071 N N   . GLY A 1 153 ? 118.470 97.455  101.711 1.00 96.54  ?  153 GLY A N   1 
ATOM 1072 C CA  . GLY A 1 153 ? 119.792 97.911  102.100 1.00 93.18  ?  153 GLY A CA  1 
ATOM 1073 C C   . GLY A 1 153 ? 120.839 96.932  101.594 1.00 94.15  ?  153 GLY A C   1 
ATOM 1074 O O   . GLY A 1 153 ? 121.858 97.370  101.082 1.00 99.10  ?  153 GLY A O   1 
ATOM 1075 N N   . TYR A 1 154 ? 120.611 95.626  101.737 1.00 99.11  ?  154 TYR A N   1 
ATOM 1076 C CA  . TYR A 1 154 ? 121.529 94.633  101.209 1.00 101.60 ?  154 TYR A CA  1 
ATOM 1077 C C   . TYR A 1 154 ? 121.534 94.692  99.708  1.00 106.12 ?  154 TYR A C   1 
ATOM 1078 O O   . TYR A 1 154 ? 122.587 94.653  99.085  1.00 116.17 ?  154 TYR A O   1 
ATOM 1079 C CB  . TYR A 1 154 ? 121.145 93.230  101.641 1.00 102.17 ?  154 TYR A CB  1 
ATOM 1080 C CG  . TYR A 1 154 ? 121.900 92.146  100.913 1.00 103.97 ?  154 TYR A CG  1 
ATOM 1081 C CD1 . TYR A 1 154 ? 123.251 91.941  101.143 1.00 107.01 ?  154 TYR A CD1 1 
ATOM 1082 C CD2 . TYR A 1 154 ? 121.260 91.326  99.997  1.00 104.52 ?  154 TYR A CD2 1 
ATOM 1083 C CE1 . TYR A 1 154 ? 123.945 90.954  100.475 1.00 106.41 ?  154 TYR A CE1 1 
ATOM 1084 C CE2 . TYR A 1 154 ? 121.947 90.337  99.324  1.00 108.96 ?  154 TYR A CE2 1 
ATOM 1085 C CZ  . TYR A 1 154 ? 123.288 90.155  99.569  1.00 110.54 ?  154 TYR A CZ  1 
ATOM 1086 O OH  . TYR A 1 154 ? 123.972 89.168  98.902  1.00 111.58 ?  154 TYR A OH  1 
ATOM 1087 N N   . LEU A 1 155 ? 120.363 94.792  99.101  1.00 101.11 ?  155 LEU A N   1 
ATOM 1088 C CA  . LEU A 1 155 ? 120.301 94.768  97.652  1.00 98.84  ?  155 LEU A CA  1 
ATOM 1089 C C   . LEU A 1 155 ? 120.965 96.003  97.050  1.00 100.33 ?  155 LEU A C   1 
ATOM 1090 O O   . LEU A 1 155 ? 121.494 95.935  95.954  1.00 96.84  ?  155 LEU A O   1 
ATOM 1091 C CB  . LEU A 1 155 ? 118.863 94.601  97.176  1.00 94.20  ?  155 LEU A CB  1 
ATOM 1092 C CG  . LEU A 1 155 ? 118.186 93.285  97.528  1.00 99.44  ?  155 LEU A CG  1 
ATOM 1093 C CD1 . LEU A 1 155 ? 116.724 93.332  97.117  1.00 100.05 ?  155 LEU A CD1 1 
ATOM 1094 C CD2 . LEU A 1 155 ? 118.911 92.146  96.835  1.00 102.19 ?  155 LEU A CD2 1 
ATOM 1095 N N   . ALA A 1 156 ? 120.979 97.122  97.765  1.00 100.11 ?  156 ALA A N   1 
ATOM 1096 C CA  . ALA A 1 156 ? 121.563 98.344  97.229  1.00 94.82  ?  156 ALA A CA  1 
ATOM 1097 C C   . ALA A 1 156 ? 123.055 98.217  97.200  1.00 99.39  ?  156 ALA A C   1 
ATOM 1098 O O   . ALA A 1 156 ? 123.703 98.715  96.296  1.00 102.82 ?  156 ALA A O   1 
ATOM 1099 C CB  . ALA A 1 156 ? 121.156 99.544  98.043  1.00 95.37  ?  156 ALA A CB  1 
ATOM 1100 N N   . ASP A 1 157 ? 123.629 97.549  98.193  1.00 105.28 ?  157 ASP A N   1 
ATOM 1101 C CA  . ASP A 1 157 ? 125.068 97.349  98.235  1.00 99.99  ?  157 ASP A CA  1 
ATOM 1102 C C   . ASP A 1 157 ? 125.493 96.338  97.200  1.00 104.16 ?  157 ASP A C   1 
ATOM 1103 O O   . ASP A 1 157 ? 126.656 96.303  96.824  1.00 110.69 ?  157 ASP A O   1 
ATOM 1104 C CB  . ASP A 1 157 ? 125.506 96.860  99.614  1.00 100.48 ?  157 ASP A CB  1 
ATOM 1105 C CG  . ASP A 1 157 ? 125.172 97.839  100.726 1.00 109.77 ?  157 ASP A CG  1 
ATOM 1106 O OD1 . ASP A 1 157 ? 124.926 99.030  100.439 1.00 109.34 ?  157 ASP A OD1 1 
ATOM 1107 O OD2 . ASP A 1 157 ? 125.162 97.412  101.899 1.00 110.37 -1 157 ASP A OD2 1 
ATOM 1108 N N   . ARG A 1 158 ? 124.569 95.502  96.755  1.00 105.98 ?  158 ARG A N   1 
ATOM 1109 C CA  . ARG A 1 158 ? 124.876 94.483  95.766  1.00 105.00 ?  158 ARG A CA  1 
ATOM 1110 C C   . ARG A 1 158 ? 124.560 94.937  94.351  1.00 102.10 ?  158 ARG A C   1 
ATOM 1111 O O   . ARG A 1 158 ? 125.345 94.618  93.460  1.00 104.85 ?  158 ARG A O   1 
ATOM 1112 C CB  . ARG A 1 158 ? 124.103 93.206  96.084  1.00 105.81 ?  158 ARG A CB  1 
ATOM 1113 C CG  . ARG A 1 158 ? 124.538 91.997  95.276  1.00 105.19 ?  158 ARG A CG  1 
ATOM 1114 C CD  . ARG A 1 158 ? 123.860 90.721  95.743  1.00 106.40 ?  158 ARG A CD  1 
ATOM 1115 N NE  . ARG A 1 158 ? 123.300 89.979  94.612  1.00 108.09 ?  158 ARG A NE  1 
ATOM 1116 C CZ  . ARG A 1 158 ? 122.114 90.210  94.035  1.00 108.11 ?  158 ARG A CZ  1 
ATOM 1117 N NH1 . ARG A 1 158 ? 121.303 91.186  94.458  1.00 105.48 1  158 ARG A NH1 1 
ATOM 1118 N NH2 . ARG A 1 158 ? 121.730 89.453  93.007  1.00 102.89 ?  158 ARG A NH2 1 
ATOM 1119 N N   . LEU A 1 159 ? 123.448 95.663  94.135  1.00 102.30 ?  159 LEU A N   1 
ATOM 1120 C CA  . LEU A 1 159 ? 123.024 96.071  92.782  1.00 108.77 ?  159 LEU A CA  1 
ATOM 1121 C C   . LEU A 1 159 ? 123.116 97.558  92.445  1.00 104.64 ?  159 LEU A C   1 
ATOM 1122 O O   . LEU A 1 159 ? 122.973 97.938  91.293  1.00 99.38  ?  159 LEU A O   1 
ATOM 1123 C CB  . LEU A 1 159 ? 121.605 95.565  92.508  1.00 105.27 ?  159 LEU A CB  1 
ATOM 1124 C CG  . LEU A 1 159 ? 121.393 94.057  92.442  1.00 104.42 ?  159 LEU A CG  1 
ATOM 1125 C CD1 . LEU A 1 159 ? 119.919 93.770  92.223  1.00 99.61  ?  159 LEU A CD1 1 
ATOM 1126 C CD2 . LEU A 1 159 ? 122.228 93.460  91.322  1.00 101.59 ?  159 LEU A CD2 1 
ATOM 1127 N N   . GLY A 1 160 ? 123.360 98.420  93.423  1.00 101.97 ?  160 GLY A N   1 
ATOM 1128 C CA  . GLY A 1 160 ? 123.530 99.840  93.172  1.00 98.16  ?  160 GLY A CA  1 
ATOM 1129 C C   . GLY A 1 160 ? 122.443 100.639 93.824  1.00 102.10 ?  160 GLY A C   1 
ATOM 1130 O O   . GLY A 1 160 ? 121.330 100.165 93.953  1.00 111.63 ?  160 GLY A O   1 
ATOM 1131 N N   . ARG A 1 161 ? 122.760 101.848 94.250  1.00 90.16  ?  161 ARG A N   1 
ATOM 1132 C CA  . ARG A 1 161 ? 121.762 102.695 94.861  1.00 92.51  ?  161 ARG A CA  1 
ATOM 1133 C C   . ARG A 1 161 ? 120.696 103.032 93.851  1.00 98.65  ?  161 ARG A C   1 
ATOM 1134 O O   . ARG A 1 161 ? 119.529 103.070 94.194  1.00 103.60 ?  161 ARG A O   1 
ATOM 1135 C CB  . ARG A 1 161 ? 122.366 103.984 95.426  1.00 98.10  ?  161 ARG A CB  1 
ATOM 1136 C CG  . ARG A 1 161 ? 123.494 103.840 96.446  1.00 98.84  ?  161 ARG A CG  1 
ATOM 1137 C CD  . ARG A 1 161 ? 123.274 102.702 97.436  1.00 99.69  ?  161 ARG A CD  1 
ATOM 1138 N NE  . ARG A 1 161 ? 123.966 102.903 98.708  1.00 100.86 ?  161 ARG A NE  1 
ATOM 1139 C CZ  . ARG A 1 161 ? 125.279 102.776 98.913  1.00 102.16 ?  161 ARG A CZ  1 
ATOM 1140 N NH1 . ARG A 1 161 ? 126.109 102.433 97.934  1.00 100.06 1  161 ARG A NH1 1 
ATOM 1141 N NH2 . ARG A 1 161 ? 125.769 103.000 100.131 1.00 101.20 ?  161 ARG A NH2 1 
ATOM 1142 N N   . ARG A 1 162 ? 121.089 103.324 92.619  1.00 96.48  ?  162 ARG A N   1 
ATOM 1143 C CA  . ARG A 1 162 ? 120.127 103.631 91.560  1.00 96.46  ?  162 ARG A CA  1 
ATOM 1144 C C   . ARG A 1 162 ? 119.233 102.503 91.104  1.00 98.60  ?  162 ARG A C   1 
ATOM 1145 O O   . ARG A 1 162 ? 118.049 102.706 90.993  1.00 96.91  ?  162 ARG A O   1 
ATOM 1146 C CB  . ARG A 1 162 ? 120.851 104.150 90.330  1.00 99.02  ?  162 ARG A CB  1 
ATOM 1147 C CG  . ARG A 1 162 ? 119.973 104.398 89.123  1.00 96.70  ?  162 ARG A CG  1 
ATOM 1148 C CD  . ARG A 1 162 ? 120.840 104.810 87.969  1.00 92.47  ?  162 ARG A CD  1 
ATOM 1149 N NE  . ARG A 1 162 ? 120.169 104.581 86.692  1.00 95.65  ?  162 ARG A NE  1 
ATOM 1150 C CZ  . ARG A 1 162 ? 120.085 103.401 86.065  1.00 102.06 ?  162 ARG A CZ  1 
ATOM 1151 N NH1 . ARG A 1 162 ? 120.607 102.286 86.588  1.00 101.96 1  162 ARG A NH1 1 
ATOM 1152 N NH2 . ARG A 1 162 ? 119.447 103.327 84.900  1.00 106.99 ?  162 ARG A NH2 1 
ATOM 1153 N N   . LYS A 1 163 ? 119.765 101.316 90.852  1.00 97.88  ?  163 LYS A N   1 
ATOM 1154 C CA  . LYS A 1 163 ? 118.936 100.245 90.309  1.00 91.42  ?  163 LYS A CA  1 
ATOM 1155 C C   . LYS A 1 163 ? 117.931 99.887  91.347  1.00 90.97  ?  163 LYS A C   1 
ATOM 1156 O O   . LYS A 1 163 ? 116.787 99.673  91.020  1.00 101.54 ?  163 LYS A O   1 
ATOM 1157 C CB  . LYS A 1 163 ? 119.732 99.010  89.936  1.00 89.79  ?  163 LYS A CB  1 
ATOM 1158 C CG  . LYS A 1 163 ? 120.658 99.203  88.752  1.00 96.03  ?  163 LYS A CG  1 
ATOM 1159 C CD  . LYS A 1 163 ? 121.219 97.873  88.285  1.00 104.08 ?  163 LYS A CD  1 
ATOM 1160 C CE  . LYS A 1 163 ? 122.258 98.062  87.195  1.00 103.50 ?  163 LYS A CE  1 
ATOM 1161 N NZ  . LYS A 1 163 ? 122.844 96.765  86.763  1.00 98.07  1  163 LYS A NZ  1 
ATOM 1162 N N   . VAL A 1 164 ? 118.340 99.828  92.603  1.00 83.93  ?  164 VAL A N   1 
ATOM 1163 C CA  . VAL A 1 164 ? 117.399 99.569  93.688  1.00 82.87  ?  164 VAL A CA  1 
ATOM 1164 C C   . VAL A 1 164 ? 116.363 100.684 93.810  1.00 89.10  ?  164 VAL A C   1 
ATOM 1165 O O   . VAL A 1 164 ? 115.230 100.385 94.105  1.00 101.63 ?  164 VAL A O   1 
ATOM 1166 C CB  . VAL A 1 164 ? 118.074 99.172  95.015  1.00 77.84  ?  164 VAL A CB  1 
ATOM 1167 C CG1 . VAL A 1 164 ? 117.036 98.912  96.093  1.00 77.64  ?  164 VAL A CG1 1 
ATOM 1168 C CG2 . VAL A 1 164 ? 118.886 97.896  94.813  1.00 88.72  ?  164 VAL A CG2 1 
ATOM 1169 N N   . LEU A 1 165 ? 116.709 101.950 93.603  1.00 85.30  ?  165 LEU A N   1 
ATOM 1170 C CA  . LEU A 1 165 ? 115.683 103.013 93.599  1.00 82.29  ?  165 LEU A CA  1 
ATOM 1171 C C   . LEU A 1 165 ? 114.674 102.845 92.468  1.00 85.58  ?  165 LEU A C   1 
ATOM 1172 O O   . LEU A 1 165 ? 113.500 103.040 92.689  1.00 95.69  ?  165 LEU A O   1 
ATOM 1173 C CB  . LEU A 1 165 ? 116.256 104.429 93.482  1.00 91.04  ?  165 LEU A CB  1 
ATOM 1174 C CG  . LEU A 1 165 ? 116.482 105.270 94.732  1.00 96.99  ?  165 LEU A CG  1 
ATOM 1175 C CD1 . LEU A 1 165 ? 117.105 106.612 94.372  1.00 98.43  ?  165 LEU A CD1 1 
ATOM 1176 C CD2 . LEU A 1 165 ? 115.209 105.470 95.545  1.00 85.68  ?  165 LEU A CD2 1 
ATOM 1177 N N   . ILE A 1 166 ? 115.114 102.512 91.260  1.00 78.69  ?  166 ILE A N   1 
ATOM 1178 C CA  . ILE A 1 166 ? 114.209 102.358 90.136  1.00 73.64  ?  166 ILE A CA  1 
ATOM 1179 C C   . ILE A 1 166 ? 113.213 101.261 90.454  1.00 82.81  ?  166 ILE A C   1 
ATOM 1180 O O   . ILE A 1 166 ? 112.016 101.441 90.264  1.00 95.08  ?  166 ILE A O   1 
ATOM 1181 C CB  . ILE A 1 166 ? 114.974 101.973 88.860  1.00 78.51  ?  166 ILE A CB  1 
ATOM 1182 C CG1 . ILE A 1 166 ? 115.884 103.105 88.404  1.00 79.88  ?  166 ILE A CG1 1 
ATOM 1183 C CG2 . ILE A 1 166 ? 114.027 101.607 87.738  1.00 82.07  ?  166 ILE A CG2 1 
ATOM 1184 C CD1 . ILE A 1 166 ? 116.768 102.726 87.241  1.00 78.94  ?  166 ILE A CD1 1 
ATOM 1185 N N   . LEU A 1 167 ? 113.675 100.136 90.983  1.00 73.18  ?  167 LEU A N   1 
ATOM 1186 C CA  . LEU A 1 167 ? 112.782 99.033  91.317  1.00 68.70  ?  167 LEU A CA  1 
ATOM 1187 C C   . LEU A 1 167 ? 111.877 99.385  92.471  1.00 75.15  ?  167 LEU A C   1 
ATOM 1188 O O   . LEU A 1 167 ? 110.757 98.915  92.527  1.00 77.88  ?  167 LEU A O   1 
ATOM 1189 C CB  . LEU A 1 167 ? 113.567 97.771  91.625  1.00 71.12  ?  167 LEU A CB  1 
ATOM 1190 C CG  . LEU A 1 167 ? 114.454 97.248  90.501  1.00 76.17  ?  167 LEU A CG  1 
ATOM 1191 C CD1 . LEU A 1 167 ? 115.280 96.069  90.984  1.00 77.32  ?  167 LEU A CD1 1 
ATOM 1192 C CD2 . LEU A 1 167 ? 113.619 96.876  89.289  1.00 77.67  ?  167 LEU A CD2 1 
ATOM 1193 N N   . ASN A 1 168 ? 112.330 100.212 93.405  1.00 75.39  ?  168 ASN A N   1 
ATOM 1194 C CA  . ASN A 1 168 ? 111.479 100.637 94.508  1.00 68.94  ?  168 ASN A CA  1 
ATOM 1195 C C   . ASN A 1 168 ? 110.391 101.599 94.086  1.00 78.53  ?  168 ASN A C   1 
ATOM 1196 O O   . ASN A 1 168 ? 109.319 101.548 94.633  1.00 89.14  ?  168 ASN A O   1 
ATOM 1197 C CB  . ASN A 1 168 ? 112.277 101.272 95.627  1.00 70.47  ?  168 ASN A CB  1 
ATOM 1198 C CG  . ASN A 1 168 ? 113.196 100.300 96.320  1.00 85.94  ?  168 ASN A CG  1 
ATOM 1199 O OD1 . ASN A 1 168 ? 113.035 99.090  96.220  1.00 91.39  ?  168 ASN A OD1 1 
ATOM 1200 N ND2 . ASN A 1 168 ? 114.167 100.830 97.035  1.00 92.09  ?  168 ASN A ND2 1 
ATOM 1201 N N   . TYR A 1 169 ? 110.640 102.488 93.140  1.00 79.23  ?  169 TYR A N   1 
ATOM 1202 C CA  . TYR A 1 169 ? 109.575 103.353 92.646  1.00 74.37  ?  169 TYR A CA  1 
ATOM 1203 C C   . TYR A 1 169 ? 108.505 102.525 91.971  1.00 77.47  ?  169 TYR A C   1 
ATOM 1204 O O   . TYR A 1 169 ? 107.335 102.807 92.125  1.00 85.52  ?  169 TYR A O   1 
ATOM 1205 C CB  . TYR A 1 169 ? 110.081 104.427 91.688  1.00 73.40  ?  169 TYR A CB  1 
ATOM 1206 C CG  . TYR A 1 169 ? 111.042 105.437 92.280  1.00 80.47  ?  169 TYR A CG  1 
ATOM 1207 C CD1 . TYR A 1 169 ? 110.758 106.100 93.464  1.00 78.89  ?  169 TYR A CD1 1 
ATOM 1208 C CD2 . TYR A 1 169 ? 112.223 105.751 91.630  1.00 80.03  ?  169 TYR A CD2 1 
ATOM 1209 C CE1 . TYR A 1 169 ? 111.632 107.021 93.993  1.00 83.69  ?  169 TYR A CE1 1 
ATOM 1210 C CE2 . TYR A 1 169 ? 113.101 106.673 92.153  1.00 76.30  ?  169 TYR A CE2 1 
ATOM 1211 C CZ  . TYR A 1 169 ? 112.799 107.307 93.331  1.00 82.33  ?  169 TYR A CZ  1 
ATOM 1212 O OH  . TYR A 1 169 ? 113.681 108.222 93.847  1.00 90.47  ?  169 TYR A OH  1 
ATOM 1213 N N   . LEU A 1 170 ? 108.896 101.507 91.219  1.00 72.67  ?  170 LEU A N   1 
ATOM 1214 C CA  . LEU A 1 170 ? 107.928 100.639 90.558  1.00 70.99  ?  170 LEU A CA  1 
ATOM 1215 C C   . LEU A 1 170 ? 107.145 99.802  91.545  1.00 79.87  ?  170 LEU A C   1 
ATOM 1216 O O   . LEU A 1 170 ? 105.975 99.617  91.344  1.00 83.48  ?  170 LEU A O   1 
ATOM 1217 C CB  . LEU A 1 170 ? 108.593 99.696  89.565  1.00 76.45  ?  170 LEU A CB  1 
ATOM 1218 C CG  . LEU A 1 170 ? 107.715 98.762  88.725  1.00 74.76  ?  170 LEU A CG  1 
ATOM 1219 C CD1 . LEU A 1 170 ? 106.769 99.542  87.821  1.00 78.02  ?  170 LEU A CD1 1 
ATOM 1220 C CD2 . LEU A 1 170 ? 108.598 97.832  87.910  1.00 76.56  ?  170 LEU A CD2 1 
ATOM 1221 N N   . GLN A 1 171 ? 107.780 99.263  92.581  1.00 72.96  ?  171 GLN A N   1 
ATOM 1222 C CA  . GLN A 1 171 ? 107.091 98.471  93.589  1.00 61.42  ?  171 GLN A CA  1 
ATOM 1223 C C   . GLN A 1 171 ? 106.091 99.282  94.394  1.00 72.23  ?  171 GLN A C   1 
ATOM 1224 O O   . GLN A 1 171 ? 104.988 98.827  94.600  1.00 80.48  ?  171 GLN A O   1 
ATOM 1225 C CB  . GLN A 1 171 ? 108.060 97.750  94.508  1.00 59.54  ?  171 GLN A CB  1 
ATOM 1226 C CG  . GLN A 1 171 ? 107.398 96.859  95.540  1.00 67.60  ?  171 GLN A CG  1 
ATOM 1227 C CD  . GLN A 1 171 ? 108.409 96.166  96.418  1.00 79.25  ?  171 GLN A CD  1 
ATOM 1228 O OE1 . GLN A 1 171 ? 109.557 95.987  96.027  1.00 82.55  ?  171 GLN A OE1 1 
ATOM 1229 N NE2 . GLN A 1 171 ? 107.990 95.769  97.607  1.00 72.07  ?  171 GLN A NE2 1 
ATOM 1230 N N   . THR A 1 172 ? 106.438 100.491 94.821  1.00 76.39  ?  172 THR A N   1 
ATOM 1231 C CA  . THR A 1 172 ? 105.490 101.338 95.535  1.00 72.31  ?  172 THR A CA  1 
ATOM 1232 C C   . THR A 1 172 ? 104.309 101.674 94.661  1.00 75.24  ?  172 THR A C   1 
ATOM 1233 O O   . THR A 1 172 ? 103.177 101.665 95.117  1.00 88.88  ?  172 THR A O   1 
ATOM 1234 C CB  . THR A 1 172 ? 106.113 102.661 95.976  1.00 78.05  ?  172 THR A CB  1 
ATOM 1235 O OG1 . THR A 1 172 ? 107.323 102.415 96.693  1.00 85.07  ?  172 THR A OG1 1 
ATOM 1236 C CG2 . THR A 1 172 ? 105.158 103.425 96.864  1.00 68.64  ?  172 THR A CG2 1 
ATOM 1237 N N   . ALA A 1 173 ? 104.558 101.962 93.397  1.00 67.77  ?  173 ALA A N   1 
ATOM 1238 C CA  . ALA A 1 173 ? 103.492 102.283 92.475  1.00 68.11  ?  173 ALA A CA  1 
ATOM 1239 C C   . ALA A 1 173 ? 102.575 101.110 92.221  1.00 72.51  ?  173 ALA A C   1 
ATOM 1240 O O   . ALA A 1 173 ? 101.367 101.259 92.284  1.00 82.64  ?  173 ALA A O   1 
ATOM 1241 C CB  . ALA A 1 173 ? 104.082 102.745 91.180  1.00 73.69  ?  173 ALA A CB  1 
ATOM 1242 N N   . VAL A 1 174 ? 103.134 99.944  91.917  1.00 78.53  ?  174 VAL A N   1 
ATOM 1243 C CA  . VAL A 1 174 ? 102.330 98.759  91.670  1.00 80.59  ?  174 VAL A CA  1 
ATOM 1244 C C   . VAL A 1 174 ? 101.605 98.275  92.917  1.00 86.87  ?  174 VAL A C   1 
ATOM 1245 O O   . VAL A 1 174 ? 100.416 98.004  92.874  1.00 93.29  ?  174 VAL A O   1 
ATOM 1246 C CB  . VAL A 1 174 ? 103.157 97.628  91.045  1.00 78.35  ?  174 VAL A CB  1 
ATOM 1247 C CG1 . VAL A 1 174 ? 102.385 96.320  91.037  1.00 73.13  ?  174 VAL A CG1 1 
ATOM 1248 C CG2 . VAL A 1 174 ? 103.571 98.005  89.635  1.00 81.09  ?  174 VAL A CG2 1 
ATOM 1249 N N   . SER A 1 175 ? 102.303 98.185  94.037  1.00 78.39  ?  175 SER A N   1 
ATOM 1250 C CA  . SER A 1 175 ? 101.686 97.732  95.267  1.00 70.98  ?  175 SER A CA  1 
ATOM 1251 C C   . SER A 1 175 ? 100.631 98.690  95.771  1.00 76.96  ?  175 SER A C   1 
ATOM 1252 O O   . SER A 1 175 ? 99.555  98.268  96.152  1.00 86.27  ?  175 SER A O   1 
ATOM 1253 C CB  . SER A 1 175 ? 102.736 97.522  96.320  1.00 72.42  ?  175 SER A CB  1 
ATOM 1254 O OG  . SER A 1 175 ? 103.354 98.747  96.626  1.00 90.70  ?  175 SER A OG  1 
ATOM 1255 N N   . GLY A 1 176 ? 100.914 99.977  95.782  1.00 80.44  ?  176 GLY A N   1 
ATOM 1256 C CA  . GLY A 1 176 ? 99.914  100.948 96.170  1.00 76.94  ?  176 GLY A CA  1 
ATOM 1257 C C   . GLY A 1 176 ? 98.709  101.004 95.260  1.00 85.20  ?  176 GLY A C   1 
ATOM 1258 O O   . GLY A 1 176 ? 97.599  101.131 95.741  1.00 99.86  ?  176 GLY A O   1 
ATOM 1259 N N   . THR A 1 177 ? 98.899  100.927 93.951  1.00 76.46  ?  177 THR A N   1 
ATOM 1260 C CA  . THR A 1 177 ? 97.772  100.884 93.035  1.00 77.48  ?  177 THR A CA  1 
ATOM 1261 C C   . THR A 1 177 ? 96.940  99.634  93.249  1.00 86.13  ?  177 THR A C   1 
ATOM 1262 O O   . THR A 1 177 ? 95.723  99.700  93.269  1.00 100.49 ?  177 THR A O   1 
ATOM 1263 C CB  . THR A 1 177 ? 98.239  100.943 91.580  1.00 82.30  ?  177 THR A CB  1 
ATOM 1264 O OG1 . THR A 1 177 ? 98.809  102.230 91.320  1.00 93.90  ?  177 THR A OG1 1 
ATOM 1265 C CG2 . THR A 1 177 ? 97.096  100.708 90.615  1.00 84.49  ?  177 THR A CG2 1 
ATOM 1266 N N   . CYS A 1 178 ? 97.583  98.482  93.414  1.00 80.14  ?  178 CYS A N   1 
ATOM 1267 C CA  . CYS A 1 178 ? 96.862  97.240  93.644  1.00 81.19  ?  178 CYS A CA  1 
ATOM 1268 C C   . CYS A 1 178 ? 96.155  97.247  94.991  1.00 85.32  ?  178 CYS A C   1 
ATOM 1269 O O   . CYS A 1 178 ? 95.121  96.611  95.127  1.00 89.23  ?  178 CYS A O   1 
ATOM 1270 C CB  . CYS A 1 178 ? 97.801  96.048  93.526  1.00 83.62  ?  178 CYS A CB  1 
ATOM 1271 S SG  . CYS A 1 178 ? 98.410  95.737  91.856  1.00 102.80 ?  178 CYS A SG  1 
ATOM 1272 N N   . ALA A 1 179 ? 96.702  97.930  95.992  1.00 82.51  ?  179 ALA A N   1 
ATOM 1273 C CA  . ALA A 1 179 ? 96.026  98.070  97.287  1.00 77.47  ?  179 ALA A CA  1 
ATOM 1274 C C   . ALA A 1 179 ? 94.745  98.854  97.125  1.00 81.94  ?  179 ALA A C   1 
ATOM 1275 O O   . ALA A 1 179 ? 93.758  98.550  97.770  1.00 93.53  ?  179 ALA A O   1 
ATOM 1276 C CB  . ALA A 1 179 ? 96.921  98.754  98.294  1.00 65.23  ?  179 ALA A CB  1 
ATOM 1277 N N   . ALA A 1 180 ? 94.760  99.884  96.290  1.00 79.21  ?  180 ALA A N   1 
ATOM 1278 C CA  . ALA A 1 180 ? 93.573  100.688 96.034  1.00 69.67  ?  180 ALA A CA  1 
ATOM 1279 C C   . ALA A 1 180 ? 92.494  99.877  95.371  1.00 80.81  ?  180 ALA A C   1 
ATOM 1280 O O   . ALA A 1 180 ? 91.334  100.220 95.519  1.00 92.75  ?  180 ALA A O   1 
ATOM 1281 C CB  . ALA A 1 180 ? 93.912  101.854 95.140  1.00 71.24  ?  180 ALA A CB  1 
ATOM 1282 N N   . PHE A 1 181 ? 92.861  98.846  94.610  1.00 72.15  ?  181 PHE A N   1 
ATOM 1283 C CA  . PHE A 1 181 ? 91.900  97.988  93.953  1.00 67.76  ?  181 PHE A CA  1 
ATOM 1284 C C   . PHE A 1 181 ? 91.832  96.633  94.611  1.00 82.35  ?  181 PHE A C   1 
ATOM 1285 O O   . PHE A 1 181 ? 91.467  95.659  93.969  1.00 92.38  ?  181 PHE A O   1 
ATOM 1286 C CB  . PHE A 1 181 ? 92.243  97.825  92.484  1.00 73.79  ?  181 PHE A CB  1 
ATOM 1287 C CG  . PHE A 1 181 ? 92.216  99.105  91.710  1.00 78.30  ?  181 PHE A CG  1 
ATOM 1288 C CD1 . PHE A 1 181 ? 91.062  99.858  91.638  1.00 82.81  ?  181 PHE A CD1 1 
ATOM 1289 C CD2 . PHE A 1 181 ? 93.339  99.546  91.041  1.00 79.23  ?  181 PHE A CD2 1 
ATOM 1290 C CE1 . PHE A 1 181 ? 91.033  101.036 90.924  1.00 83.89  ?  181 PHE A CE1 1 
ATOM 1291 C CE2 . PHE A 1 181 ? 93.317  100.721 90.325  1.00 76.44  ?  181 PHE A CE2 1 
ATOM 1292 C CZ  . PHE A 1 181 ? 92.162  101.468 90.265  1.00 84.98  ?  181 PHE A CZ  1 
ATOM 1293 N N   . ALA A 1 182 ? 92.178  96.559  95.891  1.00 81.10  ?  182 ALA A N   1 
ATOM 1294 C CA  . ALA A 1 182 ? 92.133  95.301  96.615  1.00 78.83  ?  182 ALA A CA  1 
ATOM 1295 C C   . ALA A 1 182 ? 90.716  94.844  96.754  1.00 80.11  ?  182 ALA A C   1 
ATOM 1296 O O   . ALA A 1 182 ? 89.843  95.628  97.087  1.00 82.32  ?  182 ALA A O   1 
ATOM 1297 C CB  . ALA A 1 182 ? 92.739  95.469  97.978  1.00 76.61  ?  182 ALA A CB  1 
ATOM 1298 N N   . PRO A 1 183 ? 90.459  93.537  96.527  1.00 80.92  ?  183 PRO A N   1 
ATOM 1299 C CA  . PRO A 1 183 ? 89.082  93.078  96.601  1.00 86.12  ?  183 PRO A CA  1 
ATOM 1300 C C   . PRO A 1 183 ? 88.673  92.630  97.999  1.00 93.39  ?  183 PRO A C   1 
ATOM 1301 O O   . PRO A 1 183 ? 87.474  92.595  98.260  1.00 95.72  ?  183 PRO A O   1 
ATOM 1302 C CB  . PRO A 1 183 ? 89.084  91.896  95.661  1.00 77.65  ?  183 PRO A CB  1 
ATOM 1303 C CG  . PRO A 1 183 ? 90.419  91.295  95.829  1.00 79.97  ?  183 PRO A CG  1 
ATOM 1304 C CD  . PRO A 1 183 ? 91.347  92.439  96.085  1.00 76.87  ?  183 PRO A CD  1 
ATOM 1305 N N   . ASN A 1 184 ? 89.626  92.295  98.869  1.00 89.46  ?  184 ASN A N   1 
ATOM 1306 C CA  . ASN A 1 184 ? 89.337  91.824  100.222 1.00 72.13  ?  184 ASN A CA  1 
ATOM 1307 C C   . ASN A 1 184 ? 90.429  92.284  101.164 1.00 82.61  ?  184 ASN A C   1 
ATOM 1308 O O   . ASN A 1 184 ? 91.452  92.765  100.706 1.00 93.42  ?  184 ASN A O   1 
ATOM 1309 C CB  . ASN A 1 184 ? 89.155  90.305  100.273 1.00 74.54  ?  184 ASN A CB  1 
ATOM 1310 C CG  . ASN A 1 184 ? 90.405  89.534  99.915  1.00 87.88  ?  184 ASN A CG  1 
ATOM 1311 O OD1 . ASN A 1 184 ? 91.246  90.011  99.183  1.00 90.13  ?  184 ASN A OD1 1 
ATOM 1312 N ND2 . ASN A 1 184 ? 90.510  88.312  100.415 1.00 88.17  ?  184 ASN A ND2 1 
ATOM 1313 N N   . PHE A 1 185 ? 90.224  92.166  102.473 1.00 84.47  ?  185 PHE A N   1 
ATOM 1314 C CA  . PHE A 1 185 ? 91.184  92.687  103.438 1.00 82.06  ?  185 PHE A CA  1 
ATOM 1315 C C   . PHE A 1 185 ? 92.528  91.981  103.459 1.00 81.25  ?  185 PHE A C   1 
ATOM 1316 O O   . PHE A 1 185 ? 93.540  92.655  103.529 1.00 86.20  ?  185 PHE A O   1 
ATOM 1317 C CB  . PHE A 1 185 ? 90.560  92.747  104.832 1.00 78.88  ?  185 PHE A CB  1 
ATOM 1318 C CG  . PHE A 1 185 ? 91.405  93.440  105.849 1.00 77.87  ?  185 PHE A CG  1 
ATOM 1319 C CD1 . PHE A 1 185 ? 91.668  94.791  105.738 1.00 82.82  ?  185 PHE A CD1 1 
ATOM 1320 C CD2 . PHE A 1 185 ? 91.912  92.750  106.929 1.00 82.29  ?  185 PHE A CD2 1 
ATOM 1321 C CE1 . PHE A 1 185 ? 92.438  95.435  106.669 1.00 79.63  ?  185 PHE A CE1 1 
ATOM 1322 C CE2 . PHE A 1 185 ? 92.681  93.389  107.866 1.00 79.59  ?  185 PHE A CE2 1 
ATOM 1323 C CZ  . PHE A 1 185 ? 92.939  94.732  107.734 1.00 76.32  ?  185 PHE A CZ  1 
ATOM 1324 N N   . PRO A 1 186 ? 92.564  90.632  103.415 1.00 69.70  ?  186 PRO A N   1 
ATOM 1325 C CA  . PRO A 1 186 ? 93.905  90.054  103.370 1.00 74.85  ?  186 PRO A CA  1 
ATOM 1326 C C   . PRO A 1 186 ? 94.756  90.641  102.242 1.00 77.65  ?  186 PRO A C   1 
ATOM 1327 O O   . PRO A 1 186 ? 95.921  90.927  102.473 1.00 79.39  ?  186 PRO A O   1 
ATOM 1328 C CB  . PRO A 1 186 ? 93.624  88.587  103.124 1.00 75.48  ?  186 PRO A CB  1 
ATOM 1329 C CG  . PRO A 1 186 ? 92.363  88.339  103.847 1.00 76.04  ?  186 PRO A CG  1 
ATOM 1330 C CD  . PRO A 1 186 ? 91.548  89.562  103.579 1.00 70.28  ?  186 PRO A CD  1 
ATOM 1331 N N   . ILE A 1 187 ? 94.197  90.816  101.049 1.00 81.09  ?  187 ILE A N   1 
ATOM 1332 C CA  . ILE A 1 187 ? 94.926  91.372  99.896  1.00 78.01  ?  187 ILE A CA  1 
ATOM 1333 C C   . ILE A 1 187 ? 95.371  92.816  100.081 1.00 79.39  ?  187 ILE A C   1 
ATOM 1334 O O   . ILE A 1 187 ? 96.467  93.171  99.683  1.00 89.12  ?  187 ILE A O   1 
ATOM 1335 C CB  . ILE A 1 187 ? 94.159  91.142  98.579  1.00 69.60  ?  187 ILE A CB  1 
ATOM 1336 C CG1 . ILE A 1 187 ? 94.208  89.662  98.212  1.00 64.57  ?  187 ILE A CG1 1 
ATOM 1337 C CG2 . ILE A 1 187 ? 94.739  91.950  97.439  1.00 77.06  ?  187 ILE A CG2 1 
ATOM 1338 C CD1 . ILE A 1 187 ? 93.481  89.319  96.936  1.00 73.29  ?  187 ILE A CD1 1 
ATOM 1339 N N   . TYR A 1 188 ? 94.557  93.653  100.706 1.00 83.67  ?  188 TYR A N   1 
ATOM 1340 C CA  . TYR A 1 188 ? 94.964  95.023  100.983 1.00 80.49  ?  188 TYR A CA  1 
ATOM 1341 C C   . TYR A 1 188 ? 96.170  95.017  101.888 1.00 88.64  ?  188 TYR A C   1 
ATOM 1342 O O   . TYR A 1 188 ? 97.090  95.788  101.683 1.00 91.85  ?  188 TYR A O   1 
ATOM 1343 C CB  . TYR A 1 188 ? 93.827  95.779  101.648 1.00 72.91  ?  188 TYR A CB  1 
ATOM 1344 C CG  . TYR A 1 188 ? 94.168  97.116  102.261 1.00 75.00  ?  188 TYR A CG  1 
ATOM 1345 C CD1 . TYR A 1 188 ? 94.289  98.250  101.478 1.00 84.79  ?  188 TYR A CD1 1 
ATOM 1346 C CD2 . TYR A 1 188 ? 94.325  97.250  103.632 1.00 83.10  ?  188 TYR A CD2 1 
ATOM 1347 C CE1 . TYR A 1 188 ? 94.587  99.476  102.039 1.00 84.78  ?  188 TYR A CE1 1 
ATOM 1348 C CE2 . TYR A 1 188 ? 94.626  98.469  104.200 1.00 83.39  ?  188 TYR A CE2 1 
ATOM 1349 C CZ  . TYR A 1 188 ? 94.752  99.578  103.399 1.00 80.98  ?  188 TYR A CZ  1 
ATOM 1350 O OH  . TYR A 1 188 ? 95.048  100.794 103.965 1.00 78.85  ?  188 TYR A OH  1 
ATOM 1351 N N   . CYS A 1 189 ? 96.193  94.148  102.898 1.00 87.34  ?  189 CYS A N   1 
ATOM 1352 C CA  . CYS A 1 189 ? 97.303  94.114  103.844 1.00 76.34  ?  189 CYS A CA  1 
ATOM 1353 C C   . CYS A 1 189 ? 98.574  93.628  103.188 1.00 82.54  ?  189 CYS A C   1 
ATOM 1354 O O   . CYS A 1 189 ? 99.644  94.110  103.515 1.00 90.69  ?  189 CYS A O   1 
ATOM 1355 C CB  . CYS A 1 189 ? 96.988  93.231  105.045 1.00 83.20  ?  189 CYS A CB  1 
ATOM 1356 S SG  . CYS A 1 189 ? 95.768  93.922  106.165 1.00 102.43 ?  189 CYS A SG  1 
ATOM 1357 N N   . ALA A 1 190 ? 98.472  92.666  102.284 1.00 78.95  ?  190 ALA A N   1 
ATOM 1358 C CA  . ALA A 1 190 ? 99.639  92.164  101.570 1.00 78.30  ?  190 ALA A CA  1 
ATOM 1359 C C   . ALA A 1 190 ? 100.261 93.217  100.700 1.00 82.25  ?  190 ALA A C   1 
ATOM 1360 O O   . ALA A 1 190 ? 101.470 93.331  100.665 1.00 85.35  ?  190 ALA A O   1 
ATOM 1361 C CB  . ALA A 1 190 ? 99.266  90.971  100.720 1.00 68.59  ?  190 ALA A CB  1 
ATOM 1362 N N   . PHE A 1 191 ? 99.444  93.994  99.988  1.00 80.10  ?  191 PHE A N   1 
ATOM 1363 C CA  . PHE A 1 191 ? 99.950  95.042  99.113  1.00 71.76  ?  191 PHE A CA  1 
ATOM 1364 C C   . PHE A 1 191 ? 100.357 96.266  99.882  1.00 77.61  ?  191 PHE A C   1 
ATOM 1365 O O   . PHE A 1 191 ? 101.062 97.095  99.349  1.00 93.40  ?  191 PHE A O   1 
ATOM 1366 C CB  . PHE A 1 191 ? 98.950  95.409  98.024  1.00 72.55  ?  191 PHE A CB  1 
ATOM 1367 C CG  . PHE A 1 191 ? 98.920  94.447  96.878  1.00 72.12  ?  191 PHE A CG  1 
ATOM 1368 C CD1 . PHE A 1 191 ? 100.035 94.273  96.079  1.00 76.28  ?  191 PHE A CD1 1 
ATOM 1369 C CD2 . PHE A 1 191 ? 97.775  93.742  96.581  1.00 77.47  ?  191 PHE A CD2 1 
ATOM 1370 C CE1 . PHE A 1 191 ? 100.013 93.397  95.020  1.00 80.39  ?  191 PHE A CE1 1 
ATOM 1371 C CE2 . PHE A 1 191 ? 97.746  92.865  95.521  1.00 83.25  ?  191 PHE A CE2 1 
ATOM 1372 C CZ  . PHE A 1 191 ? 98.866  92.692  94.739  1.00 81.67  ?  191 PHE A CZ  1 
ATOM 1373 N N   . ARG A 1 192 ? 99.912  96.414  101.118 1.00 73.42  ?  192 ARG A N   1 
ATOM 1374 C CA  . ARG A 1 192 ? 100.388 97.513  101.955 1.00 76.16  ?  192 ARG A CA  1 
ATOM 1375 C C   . ARG A 1 192 ? 101.744 97.144  102.568 1.00 90.40  ?  192 ARG A C   1 
ATOM 1376 O O   . ARG A 1 192 ? 102.584 98.000  102.696 1.00 97.00  ?  192 ARG A O   1 
ATOM 1377 C CB  . ARG A 1 192 ? 99.386  97.898  103.037 1.00 81.71  ?  192 ARG A CB  1 
ATOM 1378 C CG  . ARG A 1 192 ? 98.282  98.834  102.562 1.00 92.26  ?  192 ARG A CG  1 
ATOM 1379 C CD  . ARG A 1 192 ? 98.713  100.298 102.539 1.00 90.62  ?  192 ARG A CD  1 
ATOM 1380 N NE  . ARG A 1 192 ? 98.923  100.859 103.878 1.00 91.11  ?  192 ARG A NE  1 
ATOM 1381 C CZ  . ARG A 1 192 ? 99.355  102.097 104.141 1.00 92.30  ?  192 ARG A CZ  1 
ATOM 1382 N NH1 . ARG A 1 192 ? 99.637  102.961 103.160 1.00 96.15  1  192 ARG A NH1 1 
ATOM 1383 N NH2 . ARG A 1 192 ? 99.507  102.483 105.409 1.00 80.04  ?  192 ARG A NH2 1 
ATOM 1384 N N   . LEU A 1 193 ? 102.003 95.883  102.893 1.00 80.89  ?  193 LEU A N   1 
ATOM 1385 C CA  . LEU A 1 193 ? 103.317 95.501  103.400 1.00 71.32  ?  193 LEU A CA  1 
ATOM 1386 C C   . LEU A 1 193 ? 104.334 95.739  102.297 1.00 85.29  ?  193 LEU A C   1 
ATOM 1387 O O   . LEU A 1 193 ? 105.396 96.282  102.550 1.00 94.49  ?  193 LEU A O   1 
ATOM 1388 C CB  . LEU A 1 193 ? 103.322 94.034  103.819 1.00 67.76  ?  193 LEU A CB  1 
ATOM 1389 C CG  . LEU A 1 193 ? 104.519 93.419  104.538 1.00 76.95  ?  193 LEU A CG  1 
ATOM 1390 C CD1 . LEU A 1 193 ? 104.039 92.413  105.568 1.00 80.28  ?  193 LEU A CD1 1 
ATOM 1391 C CD2 . LEU A 1 193 ? 105.486 92.766  103.565 1.00 80.22  ?  193 LEU A CD2 1 
ATOM 1392 N N   . LEU A 1 194 ? 104.025 95.323  101.075 1.00 86.92  ?  194 LEU A N   1 
ATOM 1393 C CA  . LEU A 1 194 ? 104.935 95.487  99.949  1.00 84.24  ?  194 LEU A CA  1 
ATOM 1394 C C   . LEU A 1 194 ? 105.118 96.946  99.595  1.00 88.62  ?  194 LEU A C   1 
ATOM 1395 O O   . LEU A 1 194 ? 106.167 97.326  99.105  1.00 103.57 ?  194 LEU A O   1 
ATOM 1396 C CB  . LEU A 1 194 ? 104.444 94.683  98.748  1.00 73.29  ?  194 LEU A CB  1 
ATOM 1397 C CG  . LEU A 1 194 ? 104.352 93.173  98.915  1.00 78.81  ?  194 LEU A CG  1 
ATOM 1398 C CD1 . LEU A 1 194 ? 103.616 92.563  97.738  1.00 84.65  ?  194 LEU A CD1 1 
ATOM 1399 C CD2 . LEU A 1 194 ? 105.740 92.578  99.056  1.00 87.99  ?  194 LEU A CD2 1 
ATOM 1400 N N   . SER A 1 195 ? 104.104 97.770  99.808  1.00 78.99  ?  195 SER A N   1 
ATOM 1401 C CA  . SER A 1 195 ? 104.241 99.203  99.586  1.00 74.04  ?  195 SER A CA  1 
ATOM 1402 C C   . SER A 1 195 ? 105.233 99.767  100.550 1.00 78.61  ?  195 SER A C   1 
ATOM 1403 O O   . SER A 1 195 ? 106.041 100.598 100.183 1.00 83.17  ?  195 SER A O   1 
ATOM 1404 C CB  . SER A 1 195 ? 102.911 99.904  99.777  1.00 74.76  ?  195 SER A CB  1 
ATOM 1405 O OG  . SER A 1 195 ? 103.027 101.291 99.541  1.00 91.17  ?  195 SER A OG  1 
ATOM 1406 N N   . GLY A 1 196 ? 105.183 99.314  101.791 1.00 74.50  ?  196 GLY A N   1 
ATOM 1407 C CA  . GLY A 1 196 ? 106.087 99.800  102.802 1.00 74.64  ?  196 GLY A CA  1 
ATOM 1408 C C   . GLY A 1 196 ? 107.498 99.333  102.606 1.00 75.46  ?  196 GLY A C   1 
ATOM 1409 O O   . GLY A 1 196 ? 108.425 100.068 102.897 1.00 91.78  ?  196 GLY A O   1 
ATOM 1410 N N   . MET A 1 197 ? 107.674 98.116  102.106 1.00 73.58  ?  197 MET A N   1 
ATOM 1411 C CA  . MET A 1 197 ? 108.995 97.571  101.859 1.00 80.93  ?  197 MET A CA  1 
ATOM 1412 C C   . MET A 1 197 ? 109.689 98.428  100.849 1.00 87.49  ?  197 MET A C   1 
ATOM 1413 O O   . MET A 1 197 ? 110.836 98.787  101.029 1.00 93.02  ?  197 MET A O   1 
ATOM 1414 C CB  . MET A 1 197 ? 108.870 96.126  101.376 1.00 81.10  ?  197 MET A CB  1 
ATOM 1415 C CG  . MET A 1 197 ? 110.141 95.310  101.390 1.00 91.17  ?  197 MET A CG  1 
ATOM 1416 S SD  . MET A 1 197 ? 109.887 93.676  100.690 1.00 106.37 ?  197 MET A SD  1 
ATOM 1417 C CE  . MET A 1 197 ? 108.960 92.883  102.002 1.00 85.49  ?  197 MET A CE  1 
ATOM 1418 N N   . ALA A 1 198 ? 108.979 98.801  99.793  1.00 83.35  ?  198 ALA A N   1 
ATOM 1419 C CA  . ALA A 1 198 ? 109.554 99.618  98.752  1.00 73.42  ?  198 ALA A CA  1 
ATOM 1420 C C   . ALA A 1 198 ? 109.855 100.983 99.265  1.00 78.38  ?  198 ALA A C   1 
ATOM 1421 O O   . ALA A 1 198 ? 110.928 101.485 99.030  1.00 88.99  ?  198 ALA A O   1 
ATOM 1422 C CB  . ALA A 1 198 ? 108.607 99.706  97.597  1.00 81.51  ?  198 ALA A CB  1 
ATOM 1423 N N   . LEU A 1 199 ? 108.925 101.577 99.990  1.00 83.94  ?  199 LEU A N   1 
ATOM 1424 C CA  . LEU A 1 199 ? 109.110 102.921 100.540 1.00 81.03  ?  199 LEU A CA  1 
ATOM 1425 C C   . LEU A 1 199 ? 110.269 102.989 101.519 1.00 78.81  ?  199 LEU A C   1 
ATOM 1426 O O   . LEU A 1 199 ? 110.920 104.013 101.604 1.00 93.33  ?  199 LEU A O   1 
ATOM 1427 C CB  . LEU A 1 199 ? 107.820 103.480 101.148 1.00 78.30  ?  199 LEU A CB  1 
ATOM 1428 C CG  . LEU A 1 199 ? 106.769 103.953 100.142 1.00 77.24  ?  199 LEU A CG  1 
ATOM 1429 C CD1 . LEU A 1 199 ? 105.362 103.844 100.698 1.00 86.60  ?  199 LEU A CD1 1 
ATOM 1430 C CD2 . LEU A 1 199 ? 107.027 105.382 99.691  1.00 70.33  ?  199 LEU A CD2 1 
ATOM 1431 N N   . ALA A 1 200 ? 110.515 101.942 102.289 1.00 70.88  ?  200 ALA A N   1 
ATOM 1432 C CA  . ALA A 1 200 ? 111.675 101.912 103.175 1.00 75.21  ?  200 ALA A CA  1 
ATOM 1433 C C   . ALA A 1 200 ? 112.945 101.991 102.385 1.00 90.42  ?  200 ALA A C   1 
ATOM 1434 O O   . ALA A 1 200 ? 113.912 102.576 102.835 1.00 98.22  ?  200 ALA A O   1 
ATOM 1435 C CB  . ALA A 1 200 ? 111.699 100.646 103.966 1.00 81.62  ?  200 ALA A CB  1 
ATOM 1436 N N   . GLY A 1 201 ? 112.985 101.338 101.241 1.00 93.42  ?  201 GLY A N   1 
ATOM 1437 C CA  . GLY A 1 201 ? 114.151 101.386 100.390 1.00 85.18  ?  201 GLY A CA  1 
ATOM 1438 C C   . GLY A 1 201 ? 114.297 102.719 99.699  1.00 82.68  ?  201 GLY A C   1 
ATOM 1439 O O   . GLY A 1 201 ? 115.405 103.106 99.406  1.00 92.14  ?  201 GLY A O   1 
ATOM 1440 N N   . ILE A 1 202 ? 113.203 103.408 99.397  1.00 85.72  ?  202 ILE A N   1 
ATOM 1441 C CA  . ILE A 1 202 ? 113.285 104.747 98.819  1.00 85.54  ?  202 ILE A CA  1 
ATOM 1442 C C   . ILE A 1 202 ? 113.889 105.723 99.812  1.00 84.90  ?  202 ILE A C   1 
ATOM 1443 O O   . ILE A 1 202 ? 114.786 106.467 99.469  1.00 95.25  ?  202 ILE A O   1 
ATOM 1444 C CB  . ILE A 1 202 ? 111.901 105.254 98.369  1.00 84.46  ?  202 ILE A CB  1 
ATOM 1445 C CG1 . ILE A 1 202 ? 111.341 104.361 97.269  1.00 91.69  ?  202 ILE A CG1 1 
ATOM 1446 C CG2 . ILE A 1 202 ? 111.967 106.690 97.883  1.00 84.98  ?  202 ILE A CG2 1 
ATOM 1447 C CD1 . ILE A 1 202 ? 109.910 104.672 96.912  1.00 81.43  ?  202 ILE A CD1 1 
ATOM 1448 N N   . SER A 1 203 ? 113.439 105.695 101.057 1.00 86.09  ?  203 SER A N   1 
ATOM 1449 C CA  . SER A 1 203 ? 113.946 106.619 102.059 1.00 87.86  ?  203 SER A CA  1 
ATOM 1450 C C   . SER A 1 203 ? 115.427 106.429 102.323 1.00 93.70  ?  203 SER A C   1 
ATOM 1451 O O   . SER A 1 203 ? 116.149 107.403 102.489 1.00 101.51 ?  203 SER A O   1 
ATOM 1452 C CB  . SER A 1 203 ? 113.158 106.497 103.354 1.00 93.99  ?  203 SER A CB  1 
ATOM 1453 O OG  . SER A 1 203 ? 113.306 105.213 103.924 1.00 101.98 ?  203 SER A OG  1 
ATOM 1454 N N   . LEU A 1 204 ? 115.890 105.190 102.345 1.00 92.89  ?  204 LEU A N   1 
ATOM 1455 C CA  . LEU A 1 204 ? 117.302 104.912 102.544 1.00 95.53  ?  204 LEU A CA  1 
ATOM 1456 C C   . LEU A 1 204 ? 118.122 105.312 101.338 1.00 95.64  ?  204 LEU A C   1 
ATOM 1457 O O   . LEU A 1 204 ? 119.022 106.130 101.451 1.00 94.69  ?  204 LEU A O   1 
ATOM 1458 C CB  . LEU A 1 204 ? 117.494 103.427 102.820 1.00 93.06  ?  204 LEU A CB  1 
ATOM 1459 C CG  . LEU A 1 204 ? 118.886 102.838 102.623 1.00 96.28  ?  204 LEU A CG  1 
ATOM 1460 C CD1 . LEU A 1 204 ? 119.858 103.423 103.633 1.00 99.13  ?  204 LEU A CD1 1 
ATOM 1461 C CD2 . LEU A 1 204 ? 118.822 101.325 102.750 1.00 95.07  ?  204 LEU A CD2 1 
ATOM 1462 N N   . ASN A 1 205 ? 117.814 104.754 100.176 1.00 102.82 ?  205 ASN A N   1 
ATOM 1463 C CA  . ASN A 1 205 ? 118.588 105.030 98.968  1.00 95.17  ?  205 ASN A CA  1 
ATOM 1464 C C   . ASN A 1 205 ? 118.532 106.484 98.545  1.00 96.98  ?  205 ASN A C   1 
ATOM 1465 O O   . ASN A 1 205 ? 119.383 106.931 97.789  1.00 100.67 ?  205 ASN A O   1 
ATOM 1466 C CB  . ASN A 1 205 ? 118.124 104.127 97.833  1.00 94.69  ?  205 ASN A CB  1 
ATOM 1467 C CG  . ASN A 1 205 ? 118.367 102.664 98.121  1.00 99.06  ?  205 ASN A CG  1 
ATOM 1468 O OD1 . ASN A 1 205 ? 119.326 102.307 98.801  1.00 102.97 ?  205 ASN A OD1 1 
ATOM 1469 N ND2 . ASN A 1 205 ? 117.501 101.807 97.601  1.00 100.59 ?  205 ASN A ND2 1 
ATOM 1470 N N   . CYS A 1 206 ? 117.538 107.227 99.004  1.00 107.85 ?  206 CYS A N   1 
ATOM 1471 C CA  . CYS A 1 206 ? 117.498 108.655 98.712  1.00 110.29 ?  206 CYS A CA  1 
ATOM 1472 C C   . CYS A 1 206 ? 118.584 109.387 99.471  1.00 110.29 ?  206 CYS A C   1 
ATOM 1473 O O   . CYS A 1 206 ? 119.165 110.338 98.960  1.00 111.43 ?  206 CYS A O   1 
ATOM 1474 C CB  . CYS A 1 206 ? 116.160 109.261 99.081  1.00 110.87 ?  206 CYS A CB  1 
ATOM 1475 S SG  . CYS A 1 206 ? 116.201 111.061 99.041  1.00 131.63 ?  206 CYS A SG  1 
ATOM 1476 N N   . MET A 1 207 ? 118.853 108.972 100.699 1.00 118.92 ?  207 MET A N   1 
ATOM 1477 C CA  . MET A 1 207 ? 119.939 109.575 101.444 1.00 119.32 ?  207 MET A CA  1 
ATOM 1478 C C   . MET A 1 207 ? 121.250 109.178 100.813 1.00 117.31 ?  207 MET A C   1 
ATOM 1479 O O   . MET A 1 207 ? 122.002 110.030 100.356 1.00 116.89 ?  207 MET A O   1 
ATOM 1480 C CB  . MET A 1 207 ? 119.922 109.107 102.890 1.00 121.38 ?  207 MET A CB  1 
ATOM 1481 C CG  . MET A 1 207 ? 120.963 109.779 103.765 1.00 121.04 ?  207 MET A CG  1 
ATOM 1482 S SD  . MET A 1 207 ? 120.523 111.483 104.151 1.00 137.75 ?  207 MET A SD  1 
ATOM 1483 C CE  . MET A 1 207 ? 119.063 111.228 105.153 1.00 124.56 ?  207 MET A CE  1 
ATOM 1484 N N   . THR A 1 208 ? 121.517 107.883 100.743 1.00 114.05 ?  208 THR A N   1 
ATOM 1485 C CA  . THR A 1 208 ? 122.793 107.418 100.219 1.00 110.23 ?  208 THR A CA  1 
ATOM 1486 C C   . THR A 1 208 ? 123.144 108.020 98.864  1.00 106.65 ?  208 THR A C   1 
ATOM 1487 O O   . THR A 1 208 ? 124.269 108.453 98.668  1.00 106.08 ?  208 THR A O   1 
ATOM 1488 C CB  . THR A 1 208 ? 122.829 105.885 100.119 1.00 112.82 ?  208 THR A CB  1 
ATOM 1489 O OG1 . THR A 1 208 ? 121.858 105.446 99.164  1.00 114.64 ?  208 THR A OG1 1 
ATOM 1490 C CG2 . THR A 1 208 ? 122.524 105.262 101.467 1.00 110.63 ?  208 THR A CG2 1 
ATOM 1491 N N   . LEU A 1 209 ? 122.214 108.058 97.924  1.00 104.87 ?  209 LEU A N   1 
ATOM 1492 C CA  . LEU A 1 209 ? 122.589 108.549 96.595  1.00 106.74 ?  209 LEU A CA  1 
ATOM 1493 C C   . LEU A 1 209 ? 122.899 110.034 96.617  1.00 109.27 ?  209 LEU A C   1 
ATOM 1494 O O   . LEU A 1 209 ? 123.839 110.463 95.969  1.00 111.70 ?  209 LEU A O   1 
ATOM 1495 C CB  . LEU A 1 209 ? 121.526 108.232 95.527  1.00 110.07 ?  209 LEU A CB  1 
ATOM 1496 C CG  . LEU A 1 209 ? 121.861 108.488 94.048  1.00 106.27 ?  209 LEU A CG  1 
ATOM 1497 C CD1 . LEU A 1 209 ? 123.051 107.662 93.569  1.00 107.53 ?  209 LEU A CD1 1 
ATOM 1498 C CD2 . LEU A 1 209 ? 120.648 108.212 93.171  1.00 100.43 ?  209 LEU A CD2 1 
ATOM 1499 N N   . ASN A 1 210 ? 122.124 110.816 97.360  1.00 115.43 ?  210 ASN A N   1 
ATOM 1500 C CA  . ASN A 1 210 ? 122.353 112.262 97.447  1.00 113.29 ?  210 ASN A CA  1 
ATOM 1501 C C   . ASN A 1 210 ? 123.587 112.584 98.267  1.00 115.83 ?  210 ASN A C   1 
ATOM 1502 O O   . ASN A 1 210 ? 124.417 113.362 97.834  1.00 109.37 ?  210 ASN A O   1 
ATOM 1503 C CB  . ASN A 1 210 ? 121.173 112.979 98.086  1.00 120.53 ?  210 ASN A CB  1 
ATOM 1504 C CG  . ASN A 1 210 ? 119.930 112.946 97.235  1.00 117.97 ?  210 ASN A CG  1 
ATOM 1505 O OD1 . ASN A 1 210 ? 119.974 112.661 96.041  1.00 119.48 ?  210 ASN A OD1 1 
ATOM 1506 N ND2 . ASN A 1 210 ? 118.808 113.261 97.850  1.00 111.29 ?  210 ASN A ND2 1 
ATOM 1507 N N   . VAL A 1 211 ? 123.718 111.984 99.444  1.00 125.89 ?  211 VAL A N   1 
ATOM 1508 C CA  . VAL A 1 211 ? 124.859 112.244 100.313 1.00 121.52 ?  211 VAL A CA  1 
ATOM 1509 C C   . VAL A 1 211 ? 126.162 111.854 99.625  1.00 123.79 ?  211 VAL A C   1 
ATOM 1510 O O   . VAL A 1 211 ? 127.122 112.610 99.680  1.00 124.29 ?  211 VAL A O   1 
ATOM 1511 C CB  . VAL A 1 211 ? 124.698 111.500 101.657 1.00 119.04 ?  211 VAL A CB  1 
ATOM 1512 C CG1 . VAL A 1 211 ? 126.014 111.379 102.399 1.00 117.70 ?  211 VAL A CG1 1 
ATOM 1513 C CG2 . VAL A 1 211 ? 123.656 112.198 102.522 1.00 119.00 ?  211 VAL A CG2 1 
ATOM 1514 N N   . GLU A 1 212 ? 126.190 110.716 98.939  1.00 122.60 ?  212 GLU A N   1 
ATOM 1515 C CA  . GLU A 1 212 ? 127.410 110.242 98.274  1.00 119.32 ?  212 GLU A CA  1 
ATOM 1516 C C   . GLU A 1 212 ? 127.779 111.040 97.039  1.00 119.37 ?  212 GLU A C   1 
ATOM 1517 O O   . GLU A 1 212 ? 128.950 111.048 96.676  1.00 118.19 ?  212 GLU A O   1 
ATOM 1518 C CB  . GLU A 1 212 ? 127.298 108.772 97.900  1.00 116.82 ?  212 GLU A CB  1 
ATOM 1519 C CG  . GLU A 1 212 ? 127.358 107.847 99.104  1.00 121.30 ?  212 GLU A CG  1 
ATOM 1520 C CD  . GLU A 1 212 ? 127.120 106.401 98.747  1.00 127.10 ?  212 GLU A CD  1 
ATOM 1521 O OE1 . GLU A 1 212 ? 127.564 105.521 99.510  1.00 125.75 ?  212 GLU A OE1 1 
ATOM 1522 O OE2 . GLU A 1 212 ? 126.497 106.142 97.702  1.00 127.05 -1 212 GLU A OE2 1 
ATOM 1523 N N   . TRP A 1 213 ? 126.812 111.707 96.402  1.00 113.15 ?  213 TRP A N   1 
ATOM 1524 C CA  . TRP A 1 213 ? 127.104 112.559 95.252  1.00 112.44 ?  213 TRP A CA  1 
ATOM 1525 C C   . TRP A 1 213 ? 127.280 114.000 95.658  1.00 109.99 ?  213 TRP A C   1 
ATOM 1526 O O   . TRP A 1 213 ? 127.497 114.857 94.813  1.00 108.15 ?  213 TRP A O   1 
ATOM 1527 C CB  . TRP A 1 213 ? 126.013 112.481 94.187  1.00 112.36 ?  213 TRP A CB  1 
ATOM 1528 C CG  . TRP A 1 213 ? 126.286 111.520 93.081  1.00 106.87 ?  213 TRP A CG  1 
ATOM 1529 C CD1 . TRP A 1 213 ? 125.502 110.479 92.698  1.00 110.90 ?  213 TRP A CD1 1 
ATOM 1530 C CD2 . TRP A 1 213 ? 127.418 111.514 92.205  1.00 106.92 ?  213 TRP A CD2 1 
ATOM 1531 N NE1 . TRP A 1 213 ? 126.072 109.823 91.639  1.00 113.11 ?  213 TRP A NE1 1 
ATOM 1532 C CE2 . TRP A 1 213 ? 127.251 110.439 91.318  1.00 107.77 ?  213 TRP A CE2 1 
ATOM 1533 C CE3 . TRP A 1 213 ? 128.556 112.315 92.082  1.00 110.71 ?  213 TRP A CE3 1 
ATOM 1534 C CZ2 . TRP A 1 213 ? 128.177 110.142 90.328  1.00 108.26 ?  213 TRP A CZ2 1 
ATOM 1535 C CZ3 . TRP A 1 213 ? 129.473 112.016 91.100  1.00 106.07 ?  213 TRP A CZ3 1 
ATOM 1536 C CH2 . TRP A 1 213 ? 129.279 110.940 90.237  1.00 103.44 ?  213 TRP A CH2 1 
ATOM 1537 N N   . MET A 1 214 ? 127.216 114.323 96.953  1.00 122.69 ?  214 MET A N   1 
ATOM 1538 C CA  . MET A 1 214 ? 127.367 115.710 97.423  1.00 124.34 ?  214 MET A CA  1 
ATOM 1539 C C   . MET A 1 214 ? 128.616 115.907 98.294  1.00 126.78 ?  214 MET A C   1 
ATOM 1540 O O   . MET A 1 214 ? 129.015 114.991 99.004  1.00 126.02 ?  214 MET A O   1 
ATOM 1541 C CB  . MET A 1 214 ? 126.106 116.197 98.147  1.00 120.95 ?  214 MET A CB  1 
ATOM 1542 C CG  . MET A 1 214 ? 124.937 116.487 97.209  1.00 123.66 ?  214 MET A CG  1 
ATOM 1543 S SD  . MET A 1 214 ? 123.902 117.861 97.717  1.00 131.81 ?  214 MET A SD  1 
ATOM 1544 C CE  . MET A 1 214 ? 125.028 119.218 97.494  1.00 124.32 ?  214 MET A CE  1 
ATOM 1545 N N   . PRO A 1 215 ? 129.232 117.107 98.251  1.00 124.20 ?  215 PRO A N   1 
ATOM 1546 C CA  . PRO A 1 215 ? 130.468 117.299 99.009  1.00 120.66 ?  215 PRO A CA  1 
ATOM 1547 C C   . PRO A 1 215 ? 130.268 117.163 100.497 1.00 124.38 ?  215 PRO A C   1 
ATOM 1548 O O   . PRO A 1 215 ? 129.158 117.370 100.956 1.00 128.32 ?  215 PRO A O   1 
ATOM 1549 C CB  . PRO A 1 215 ? 130.852 118.730 98.692  1.00 114.64 ?  215 PRO A CB  1 
ATOM 1550 C CG  . PRO A 1 215 ? 130.284 119.003 97.361  1.00 117.49 ?  215 PRO A CG  1 
ATOM 1551 C CD  . PRO A 1 215 ? 129.022 118.207 97.288  1.00 120.69 ?  215 PRO A CD  1 
ATOM 1552 N N   . ILE A 1 216 ? 131.307 116.817 101.245 1.00 130.66 ?  216 ILE A N   1 
ATOM 1553 C CA  . ILE A 1 216 ? 131.158 116.572 102.681 1.00 133.82 ?  216 ILE A CA  1 
ATOM 1554 C C   . ILE A 1 216 ? 130.785 117.828 103.473 1.00 135.87 ?  216 ILE A C   1 
ATOM 1555 O O   . ILE A 1 216 ? 130.207 117.737 104.553 1.00 136.91 ?  216 ILE A O   1 
ATOM 1556 C CB  . ILE A 1 216 ? 132.436 115.945 103.268 1.00 135.31 ?  216 ILE A CB  1 
ATOM 1557 C CG1 . ILE A 1 216 ? 132.811 114.686 102.490 1.00 134.65 ?  216 ILE A CG1 1 
ATOM 1558 C CG2 . ILE A 1 216 ? 132.249 115.614 104.739 1.00 135.44 ?  216 ILE A CG2 1 
ATOM 1559 C CD1 . ILE A 1 216 ? 134.007 113.956 103.059 1.00 132.23 ?  216 ILE A CD1 1 
ATOM 1560 N N   . HIS A 1 217 ? 131.099 118.998 102.939 1.00 138.02 ?  217 HIS A N   1 
ATOM 1561 C CA  . HIS A 1 217 ? 130.732 120.235 103.612 1.00 137.74 ?  217 HIS A CA  1 
ATOM 1562 C C   . HIS A 1 217 ? 129.252 120.530 103.447 1.00 142.46 ?  217 HIS A C   1 
ATOM 1563 O O   . HIS A 1 217 ? 128.721 121.414 104.112 1.00 143.60 ?  217 HIS A O   1 
ATOM 1564 C CB  . HIS A 1 217 ? 131.563 121.402 103.085 1.00 134.24 ?  217 HIS A CB  1 
ATOM 1565 C CG  . HIS A 1 217 ? 131.154 121.881 101.730 1.00 142.75 ?  217 HIS A CG  1 
ATOM 1566 N ND1 . HIS A 1 217 ? 130.462 123.056 101.537 1.00 142.73 ?  217 HIS A ND1 1 
ATOM 1567 C CD2 . HIS A 1 217 ? 131.349 121.352 100.501 1.00 146.17 ?  217 HIS A CD2 1 
ATOM 1568 C CE1 . HIS A 1 217 ? 130.246 123.230 100.246 1.00 141.30 ?  217 HIS A CE1 1 
ATOM 1569 N NE2 . HIS A 1 217 ? 130.770 122.207 99.595  1.00 146.14 ?  217 HIS A NE2 1 
ATOM 1570 N N   . THR A 1 218 ? 128.581 119.803 102.563 1.00 131.70 ?  218 THR A N   1 
ATOM 1571 C CA  . THR A 1 218 ? 127.163 120.018 102.335 1.00 127.86 ?  218 THR A CA  1 
ATOM 1572 C C   . THR A 1 218 ? 126.363 118.773 102.615 1.00 128.85 ?  218 THR A C   1 
ATOM 1573 O O   . THR A 1 218 ? 125.252 118.635 102.128 1.00 136.00 ?  218 THR A O   1 
ATOM 1574 C CB  . THR A 1 218 ? 126.883 120.426 100.889 1.00 128.23 ?  218 THR A CB  1 
ATOM 1575 O OG1 . THR A 1 218 ? 127.461 119.460 100.005 1.00 132.07 ?  218 THR A OG1 1 
ATOM 1576 C CG2 . THR A 1 218 ? 127.482 121.783 100.600 1.00 127.80 ?  218 THR A CG2 1 
ATOM 1577 N N   . ARG A 1 219 ? 126.919 117.855 103.389 1.00 123.31 ?  219 ARG A N   1 
ATOM 1578 C CA  . ARG A 1 219 ? 126.169 116.654 103.773 1.00 130.34 ?  219 ARG A CA  1 
ATOM 1579 C C   . ARG A 1 219 ? 125.149 116.892 104.868 1.00 134.22 ?  219 ARG A C   1 
ATOM 1580 O O   . ARG A 1 219 ? 124.082 116.291 104.846 1.00 130.33 ?  219 ARG A O   1 
ATOM 1581 C CB  . ARG A 1 219 ? 127.086 115.480 104.116 1.00 125.39 ?  219 ARG A CB  1 
ATOM 1582 C CG  . ARG A 1 219 ? 127.676 114.863 102.859 1.00 129.55 ?  219 ARG A CG  1 
ATOM 1583 C CD  . ARG A 1 219 ? 128.681 113.749 103.102 1.00 133.68 ?  219 ARG A CD  1 
ATOM 1584 N NE  . ARG A 1 219 ? 129.192 113.263 101.815 1.00 134.26 ?  219 ARG A NE  1 
ATOM 1585 C CZ  . ARG A 1 219 ? 130.110 112.307 101.643 1.00 132.33 ?  219 ARG A CZ  1 
ATOM 1586 N NH1 . ARG A 1 219 ? 130.666 111.683 102.683 1.00 132.12 1  219 ARG A NH1 1 
ATOM 1587 N NH2 . ARG A 1 219 ? 130.480 111.972 100.403 1.00 128.37 ?  219 ARG A NH2 1 
ATOM 1588 N N   . ALA A 1 220 ? 125.465 117.734 105.840 1.00 132.61 ?  220 ALA A N   1 
ATOM 1589 C CA  . ALA A 1 220 ? 124.489 118.073 106.876 1.00 127.57 ?  220 ALA A CA  1 
ATOM 1590 C C   . ALA A 1 220 ? 123.237 118.697 106.262 1.00 131.61 ?  220 ALA A C   1 
ATOM 1591 O O   . ALA A 1 220 ? 122.140 118.321 106.636 1.00 134.08 ?  220 ALA A O   1 
ATOM 1592 C CB  . ALA A 1 220 ? 125.097 119.015 107.893 1.00 126.82 ?  220 ALA A CB  1 
ATOM 1593 N N   . CYS A 1 221 ? 123.390 119.634 105.325 1.00 124.61 ?  221 CYS A N   1 
ATOM 1594 C CA  . CYS A 1 221 ? 122.248 120.254 104.655 1.00 120.54 ?  221 CYS A CA  1 
ATOM 1595 C C   . CYS A 1 221 ? 121.415 119.256 103.870 1.00 124.81 ?  221 CYS A C   1 
ATOM 1596 O O   . CYS A 1 221 ? 120.209 119.390 103.821 1.00 128.10 ?  221 CYS A O   1 
ATOM 1597 C CB  . CYS A 1 221 ? 122.703 121.363 103.719 1.00 120.77 ?  221 CYS A CB  1 
ATOM 1598 S SG  . CYS A 1 221 ? 123.838 122.542 104.479 1.00 134.38 ?  221 CYS A SG  1 
ATOM 1599 N N   . VAL A 1 222 ? 122.050 118.293 103.211 1.00 115.49 ?  222 VAL A N   1 
ATOM 1600 C CA  . VAL A 1 222 ? 121.308 117.266 102.488 1.00 116.33 ?  222 VAL A CA  1 
ATOM 1601 C C   . VAL A 1 222 ? 120.387 116.599 103.487 1.00 125.25 ?  222 VAL A C   1 
ATOM 1602 O O   . VAL A 1 222 ? 119.225 116.382 103.189 1.00 132.88 ?  222 VAL A O   1 
ATOM 1603 C CB  . VAL A 1 222 ? 122.228 116.195 101.855 1.00 118.91 ?  222 VAL A CB  1 
ATOM 1604 C CG1 . VAL A 1 222 ? 121.436 114.970 101.398 1.00 118.74 ?  222 VAL A CG1 1 
ATOM 1605 C CG2 . VAL A 1 222 ? 123.013 116.768 100.682 1.00 121.33 ?  222 VAL A CG2 1 
ATOM 1606 N N   . GLY A 1 223 ? 120.886 116.281 104.676 1.00 123.38 ?  223 GLY A N   1 
ATOM 1607 C CA  . GLY A 1 223 ? 120.103 115.576 105.667 1.00 124.03 ?  223 GLY A CA  1 
ATOM 1608 C C   . GLY A 1 223 ? 118.947 116.403 106.185 1.00 123.70 ?  223 GLY A C   1 
ATOM 1609 O O   . GLY A 1 223 ? 117.859 115.878 106.384 1.00 121.77 ?  223 GLY A O   1 
ATOM 1610 N N   . THR A 1 224 ? 119.158 117.699 106.370 1.00 119.34 ?  224 THR A N   1 
ATOM 1611 C CA  . THR A 1 224 ? 118.091 118.575 106.836 1.00 120.58 ?  224 THR A CA  1 
ATOM 1612 C C   . THR A 1 224 ? 116.997 118.733 105.793 1.00 121.03 ?  224 THR A C   1 
ATOM 1613 O O   . THR A 1 224 ? 115.821 118.613 106.106 1.00 123.99 ?  224 THR A O   1 
ATOM 1614 C CB  . THR A 1 224 ? 118.631 119.963 107.203 1.00 123.06 ?  224 THR A CB  1 
ATOM 1615 O OG1 . THR A 1 224 ? 119.437 119.863 108.382 1.00 118.67 ?  224 THR A OG1 1 
ATOM 1616 C CG2 . THR A 1 224 ? 117.491 120.927 107.464 1.00 125.10 ?  224 THR A CG2 1 
ATOM 1617 N N   . LEU A 1 225 ? 117.379 118.996 104.551 1.00 108.51 ?  225 LEU A N   1 
ATOM 1618 C CA  . LEU A 1 225 ? 116.402 119.131 103.485 1.00 112.01 ?  225 LEU A CA  1 
ATOM 1619 C C   . LEU A 1 225 ? 115.514 117.906 103.432 1.00 116.38 ?  225 LEU A C   1 
ATOM 1620 O O   . LEU A 1 225 ? 114.306 118.021 103.300 1.00 121.77 ?  225 LEU A O   1 
ATOM 1621 C CB  . LEU A 1 225 ? 117.097 119.309 102.143 1.00 111.13 ?  225 LEU A CB  1 
ATOM 1622 C CG  . LEU A 1 225 ? 116.214 119.337 100.900 1.00 114.47 ?  225 LEU A CG  1 
ATOM 1623 C CD1 . LEU A 1 225 ? 115.325 120.569 100.925 1.00 117.12 ?  225 LEU A CD1 1 
ATOM 1624 C CD2 . LEU A 1 225 ? 117.075 119.321 99.648  1.00 110.89 ?  225 LEU A CD2 1 
ATOM 1625 N N   . ILE A 1 226 ? 116.103 116.727 103.544 1.00 105.45 ?  226 ILE A N   1 
ATOM 1626 C CA  . ILE A 1 226 ? 115.326 115.500 103.511 1.00 102.47 ?  226 ILE A CA  1 
ATOM 1627 C C   . ILE A 1 226 ? 114.326 115.493 104.649 1.00 109.06 ?  226 ILE A C   1 
ATOM 1628 O O   . ILE A 1 226 ? 113.181 115.096 104.465 1.00 115.61 ?  226 ILE A O   1 
ATOM 1629 C CB  . ILE A 1 226 ? 116.225 114.260 103.589 1.00 100.36 ?  226 ILE A CB  1 
ATOM 1630 C CG1 . ILE A 1 226 ? 117.018 114.111 102.291 1.00 105.52 ?  226 ILE A CG1 1 
ATOM 1631 C CG2 . ILE A 1 226 ? 115.399 113.014 103.848 1.00 104.65 ?  226 ILE A CG2 1 
ATOM 1632 C CD1 . ILE A 1 226 ? 117.844 112.849 102.222 1.00 108.56 ?  226 ILE A CD1 1 
ATOM 1633 N N   . GLY A 1 227 ? 114.735 115.956 105.820 1.00 112.23 ?  227 GLY A N   1 
ATOM 1634 C CA  . GLY A 1 227 ? 113.840 116.013 106.962 1.00 112.90 ?  227 GLY A CA  1 
ATOM 1635 C C   . GLY A 1 227 ? 112.672 116.960 106.811 1.00 115.55 ?  227 GLY A C   1 
ATOM 1636 O O   . GLY A 1 227 ? 111.567 116.638 107.222 1.00 120.07 ?  227 GLY A O   1 
ATOM 1637 N N   . TYR A 1 228 ? 112.906 118.129 106.233 1.00 106.76 ?  228 TYR A N   1 
ATOM 1638 C CA  . TYR A 1 228 ? 111.835 119.092 106.016 1.00 99.22  ?  228 TYR A CA  1 
ATOM 1639 C C   . TYR A 1 228 ? 110.973 118.732 104.821 1.00 105.76 ?  228 TYR A C   1 
ATOM 1640 O O   . TYR A 1 228 ? 109.808 119.102 104.768 1.00 114.33 ?  228 TYR A O   1 
ATOM 1641 C CB  . TYR A 1 228 ? 112.397 120.496 105.834 1.00 103.53 ?  228 TYR A CB  1 
ATOM 1642 C CG  . TYR A 1 228 ? 112.670 121.207 107.132 1.00 114.60 ?  228 TYR A CG  1 
ATOM 1643 C CD1 . TYR A 1 228 ? 111.627 121.627 107.944 1.00 117.79 ?  228 TYR A CD1 1 
ATOM 1644 C CD2 . TYR A 1 228 ? 113.967 121.464 107.546 1.00 109.49 ?  228 TYR A CD2 1 
ATOM 1645 C CE1 . TYR A 1 228 ? 111.868 122.280 109.136 1.00 115.08 ?  228 TYR A CE1 1 
ATOM 1646 C CE2 . TYR A 1 228 ? 114.218 122.117 108.735 1.00 109.23 ?  228 TYR A CE2 1 
ATOM 1647 C CZ  . TYR A 1 228 ? 113.165 122.523 109.526 1.00 115.79 ?  228 TYR A CZ  1 
ATOM 1648 O OH  . TYR A 1 228 ? 113.411 123.174 110.711 1.00 118.97 ?  228 TYR A OH  1 
ATOM 1649 N N   . VAL A 1 229 ? 111.530 118.020 103.855 1.00 98.17  ?  229 VAL A N   1 
ATOM 1650 C CA  . VAL A 1 229 ? 110.732 117.583 102.725 1.00 97.54  ?  229 VAL A CA  1 
ATOM 1651 C C   . VAL A 1 229 ? 109.741 116.533 103.192 1.00 99.64  ?  229 VAL A C   1 
ATOM 1652 O O   . VAL A 1 229 ? 108.696 116.375 102.583 1.00 105.82 ?  229 VAL A O   1 
ATOM 1653 C CB  . VAL A 1 229 ? 111.599 117.063 101.576 1.00 91.03  ?  229 VAL A CB  1 
ATOM 1654 C CG1 . VAL A 1 229 ? 110.746 116.369 100.530 1.00 100.67 ?  229 VAL A CG1 1 
ATOM 1655 C CG2 . VAL A 1 229 ? 112.368 118.212 100.952 1.00 94.20  ?  229 VAL A CG2 1 
ATOM 1656 N N   . TYR A 1 230 ? 110.037 115.825 104.276 1.00 97.16  ?  230 TYR A N   1 
ATOM 1657 C CA  . TYR A 1 230 ? 109.071 114.873 104.820 1.00 95.50  ?  230 TYR A CA  1 
ATOM 1658 C C   . TYR A 1 230 ? 107.973 115.620 105.549 1.00 103.25 ?  230 TYR A C   1 
ATOM 1659 O O   . TYR A 1 230 ? 106.804 115.319 105.370 1.00 106.75 ?  230 TYR A O   1 
ATOM 1660 C CB  . TYR A 1 230 ? 109.742 113.881 105.756 1.00 91.98  ?  230 TYR A CB  1 
ATOM 1661 C CG  . TYR A 1 230 ? 108.772 112.953 106.448 1.00 103.76 ?  230 TYR A CG  1 
ATOM 1662 C CD1 . TYR A 1 230 ? 108.504 111.693 105.938 1.00 104.54 ?  230 TYR A CD1 1 
ATOM 1663 C CD2 . TYR A 1 230 ? 108.121 113.339 107.612 1.00 106.64 ?  230 TYR A CD2 1 
ATOM 1664 C CE1 . TYR A 1 230 ? 107.617 110.841 106.567 1.00 108.94 ?  230 TYR A CE1 1 
ATOM 1665 C CE2 . TYR A 1 230 ? 107.231 112.496 108.246 1.00 105.07 ?  230 TYR A CE2 1 
ATOM 1666 C CZ  . TYR A 1 230 ? 106.983 111.249 107.720 1.00 108.65 ?  230 TYR A CZ  1 
ATOM 1667 O OH  . TYR A 1 230 ? 106.097 110.406 108.351 1.00 103.92 ?  230 TYR A OH  1 
ATOM 1668 N N   . SER A 1 231 ? 108.335 116.592 106.369 1.00 106.84 ?  231 SER A N   1 
ATOM 1669 C CA  . SER A 1 231 ? 107.362 117.409 107.088 1.00 97.76  ?  231 SER A CA  1 
ATOM 1670 C C   . SER A 1 231 ? 106.374 118.118 106.182 1.00 100.04 ?  231 SER A C   1 
ATOM 1671 O O   . SER A 1 231 ? 105.212 118.243 106.531 1.00 104.04 ?  231 SER A O   1 
ATOM 1672 C CB  . SER A 1 231 ? 108.074 118.422 107.973 1.00 100.97 ?  231 SER A CB  1 
ATOM 1673 O OG  . SER A 1 231 ? 107.207 119.486 108.310 1.00 108.46 ?  231 SER A OG  1 
ATOM 1674 N N   . LEU A 1 232 ? 106.823 118.617 105.039 1.00 89.54  ?  232 LEU A N   1 
ATOM 1675 C CA  . LEU A 1 232 ? 105.921 119.249 104.080 1.00 87.67  ?  232 LEU A CA  1 
ATOM 1676 C C   . LEU A 1 232 ? 104.983 118.213 103.509 1.00 91.42  ?  232 LEU A C   1 
ATOM 1677 O O   . LEU A 1 232 ? 103.914 118.548 103.021 1.00 95.62  ?  232 LEU A O   1 
ATOM 1678 C CB  . LEU A 1 232 ? 106.682 119.981 102.990 1.00 86.63  ?  232 LEU A CB  1 
ATOM 1679 C CG  . LEU A 1 232 ? 107.538 121.150 103.466 1.00 96.26  ?  232 LEU A CG  1 
ATOM 1680 C CD1 . LEU A 1 232 ? 108.539 121.554 102.399 1.00 94.66  ?  232 LEU A CD1 1 
ATOM 1681 C CD2 . LEU A 1 232 ? 106.669 122.325 103.879 1.00 100.46 ?  232 LEU A CD2 1 
ATOM 1682 N N   . GLY A 1 233 ? 105.381 116.954 103.545 1.00 91.09  ?  233 GLY A N   1 
ATOM 1683 C CA  . GLY A 1 233 ? 104.530 115.878 103.084 1.00 91.20  ?  233 GLY A CA  1 
ATOM 1684 C C   . GLY A 1 233 ? 103.263 115.790 103.886 1.00 96.86  ?  233 GLY A C   1 
ATOM 1685 O O   . GLY A 1 233 ? 102.229 115.428 103.353 1.00 102.06 ?  233 GLY A O   1 
ATOM 1686 N N   . GLN A 1 234 ? 103.311 116.167 105.156 1.00 102.84 ?  234 GLN A N   1 
ATOM 1687 C CA  . GLN A 1 234 ? 102.133 116.138 106.022 1.00 94.43  ?  234 GLN A CA  1 
ATOM 1688 C C   . GLN A 1 234 ? 101.083 117.135 105.599 1.00 95.76  ?  234 GLN A C   1 
ATOM 1689 O O   . GLN A 1 234 ? 99.900  116.849 105.689 1.00 97.14  ?  234 GLN A O   1 
ATOM 1690 C CB  . GLN A 1 234 ? 102.545 116.389 107.462 1.00 89.44  ?  234 GLN A CB  1 
ATOM 1691 C CG  . GLN A 1 234 ? 103.649 115.459 107.923 1.00 103.36 ?  234 GLN A CG  1 
ATOM 1692 C CD  . GLN A 1 234 ? 103.911 115.559 109.405 1.00 108.65 ?  234 GLN A CD  1 
ATOM 1693 O OE1 . GLN A 1 234 ? 103.137 116.161 110.142 1.00 109.74 ?  234 GLN A OE1 1 
ATOM 1694 N NE2 . GLN A 1 234 ? 105.005 114.959 109.853 1.00 106.17 ?  234 GLN A NE2 1 
ATOM 1695 N N   . PHE A 1 235 ? 101.479 118.300 105.093 1.00 80.86  ?  235 PHE A N   1 
ATOM 1696 C CA  . PHE A 1 235 ? 100.501 119.237 104.556 1.00 74.03  ?  235 PHE A CA  1 
ATOM 1697 C C   . PHE A 1 235 ? 99.971  118.698 103.249 1.00 77.66  ?  235 PHE A C   1 
ATOM 1698 O O   . PHE A 1 235 ? 98.838  118.952 102.911 1.00 87.28  ?  235 PHE A O   1 
ATOM 1699 C CB  . PHE A 1 235 ? 101.104 120.590 104.241 1.00 82.52  ?  235 PHE A CB  1 
ATOM 1700 C CG  . PHE A 1 235 ? 101.702 121.293 105.409 1.00 82.01  ?  235 PHE A CG  1 
ATOM 1701 C CD1 . PHE A 1 235 ? 100.913 121.726 106.449 1.00 84.49  ?  235 PHE A CD1 1 
ATOM 1702 C CD2 . PHE A 1 235 ? 103.051 121.572 105.432 1.00 80.92  ?  235 PHE A CD2 1 
ATOM 1703 C CE1 . PHE A 1 235 ? 101.469 122.394 107.509 1.00 85.21  ?  235 PHE A CE1 1 
ATOM 1704 C CE2 . PHE A 1 235 ? 103.614 122.239 106.488 1.00 89.72  ?  235 PHE A CE2 1 
ATOM 1705 C CZ  . PHE A 1 235 ? 102.821 122.652 107.526 1.00 93.33  ?  235 PHE A CZ  1 
ATOM 1706 N N   . LEU A 1 236 ? 100.788 117.981 102.483 1.00 81.43  ?  236 LEU A N   1 
ATOM 1707 C CA  . LEU A 1 236 ? 100.324 117.385 101.239 1.00 83.52  ?  236 LEU A CA  1 
ATOM 1708 C C   . LEU A 1 236 ? 99.248  116.352 101.498 1.00 82.19  ?  236 LEU A C   1 
ATOM 1709 O O   . LEU A 1 236 ? 98.305  116.290 100.754 1.00 87.99  ?  236 LEU A O   1 
ATOM 1710 C CB  . LEU A 1 236 ? 101.475 116.765 100.431 1.00 84.94  ?  236 LEU A CB  1 
ATOM 1711 C CG  . LEU A 1 236 ? 101.194 115.980 99.145  1.00 87.81  ?  236 LEU A CG  1 
ATOM 1712 C CD1 . LEU A 1 236 ? 100.520 116.838 98.088  1.00 86.07  ?  236 LEU A CD1 1 
ATOM 1713 C CD2 . LEU A 1 236 ? 102.499 115.410 98.607  1.00 90.31  ?  236 LEU A CD2 1 
ATOM 1714 N N   . LEU A 1 237 ? 99.384  115.533 102.532 1.00 79.12  ?  237 LEU A N   1 
ATOM 1715 C CA  . LEU A 1 237 ? 98.352  114.551 102.866 1.00 82.80  ?  237 LEU A CA  1 
ATOM 1716 C C   . LEU A 1 237 ? 97.062  115.216 103.268 1.00 78.21  ?  237 LEU A C   1 
ATOM 1717 O O   . LEU A 1 237 ? 96.004  114.734 102.942 1.00 82.97  ?  237 LEU A O   1 
ATOM 1718 C CB  . LEU A 1 237 ? 98.792  113.596 103.975 1.00 81.58  ?  237 LEU A CB  1 
ATOM 1719 C CG  . LEU A 1 237 ? 97.829  112.469 104.375 1.00 83.22  ?  237 LEU A CG  1 
ATOM 1720 C CD1 . LEU A 1 237 ? 97.444  111.556 103.218 1.00 85.82  ?  237 LEU A CD1 1 
ATOM 1721 C CD2 . LEU A 1 237 ? 98.424  111.658 105.507 1.00 77.27  ?  237 LEU A CD2 1 
ATOM 1722 N N   . ALA A 1 238 ? 97.145  116.300 104.015 1.00 79.12  ?  238 ALA A N   1 
ATOM 1723 C CA  . ALA A 1 238 ? 95.957  117.007 104.422 1.00 75.86  ?  238 ALA A CA  1 
ATOM 1724 C C   . ALA A 1 238 ? 95.293  117.569 103.194 1.00 74.49  ?  238 ALA A C   1 
ATOM 1725 O O   . ALA A 1 238 ? 94.097  117.374 103.040 1.00 80.28  ?  238 ALA A O   1 
ATOM 1726 C CB  . ALA A 1 238 ? 96.278  118.113 105.399 1.00 79.69  ?  238 ALA A CB  1 
ATOM 1727 N N   . GLY A 1 239 ? 96.012  118.288 102.318 1.00 84.11  ?  239 GLY A N   1 
ATOM 1728 C CA  . GLY A 1 239 ? 95.306  118.859 101.182 1.00 79.99  ?  239 GLY A CA  1 
ATOM 1729 C C   . GLY A 1 239 ? 94.745  117.803 100.249 1.00 80.26  ?  239 GLY A C   1 
ATOM 1730 O O   . GLY A 1 239 ? 93.601  117.904 99.795  1.00 84.93  ?  239 GLY A O   1 
ATOM 1731 N N   . VAL A 1 240 ? 95.511  116.771 99.941  1.00 82.31  ?  240 VAL A N   1 
ATOM 1732 C CA  . VAL A 1 240 ? 95.061  115.709 99.038  1.00 74.90  ?  240 VAL A CA  1 
ATOM 1733 C C   . VAL A 1 240 ? 93.870  114.929 99.588  1.00 80.35  ?  240 VAL A C   1 
ATOM 1734 O O   . VAL A 1 240 ? 92.924  114.673 98.864  1.00 83.89  ?  240 VAL A O   1 
ATOM 1735 C CB  . VAL A 1 240 ? 96.220  114.767 98.697  1.00 75.22  ?  240 VAL A CB  1 
ATOM 1736 C CG1 . VAL A 1 240 ? 95.727  113.430 98.207  1.00 85.46  ?  240 VAL A CG1 1 
ATOM 1737 C CG2 . VAL A 1 240 ? 97.140  115.411 97.678  1.00 82.03  ?  240 VAL A CG2 1 
ATOM 1738 N N   . ALA A 1 241 ? 93.888  114.571 100.866 1.00 89.92  ?  241 ALA A N   1 
ATOM 1739 C CA  . ALA A 1 241 ? 92.776  113.854 101.493 1.00 81.74  ?  241 ALA A CA  1 
ATOM 1740 C C   . ALA A 1 241 ? 91.502  114.655 101.523 1.00 78.84  ?  241 ALA A C   1 
ATOM 1741 O O   . ALA A 1 241 ? 90.427  114.100 101.439 1.00 86.30  ?  241 ALA A O   1 
ATOM 1742 C CB  . ALA A 1 241 ? 93.145  113.422 102.876 1.00 80.14  ?  241 ALA A CB  1 
ATOM 1743 N N   . TYR A 1 242 ? 91.557  115.967 101.658 1.00 87.82  ?  242 TYR A N   1 
ATOM 1744 C CA  . TYR A 1 242 ? 90.336  116.748 101.612 1.00 82.00  ?  242 TYR A CA  1 
ATOM 1745 C C   . TYR A 1 242 ? 89.724  116.635 100.242 1.00 84.82  ?  242 TYR A C   1 
ATOM 1746 O O   . TYR A 1 242 ? 88.521  116.452 100.115 1.00 82.00  ?  242 TYR A O   1 
ATOM 1747 C CB  . TYR A 1 242 ? 90.625  118.207 101.941 1.00 83.10  ?  242 TYR A CB  1 
ATOM 1748 C CG  . TYR A 1 242 ? 89.393  119.047 102.124 1.00 90.14  ?  242 TYR A CG  1 
ATOM 1749 C CD1 . TYR A 1 242 ? 88.655  118.973 103.294 1.00 95.79  ?  242 TYR A CD1 1 
ATOM 1750 C CD2 . TYR A 1 242 ? 88.974  119.926 101.138 1.00 90.95  ?  242 TYR A CD2 1 
ATOM 1751 C CE1 . TYR A 1 242 ? 87.526  119.740 103.473 1.00 94.10  ?  242 TYR A CE1 1 
ATOM 1752 C CE2 . TYR A 1 242 ? 87.846  120.698 101.309 1.00 95.65  ?  242 TYR A CE2 1 
ATOM 1753 C CZ  . TYR A 1 242 ? 87.127  120.601 102.478 1.00 99.51  ?  242 TYR A CZ  1 
ATOM 1754 O OH  . TYR A 1 242 ? 86.003  121.369 102.654 1.00 98.04  ?  242 TYR A OH  1 
ATOM 1755 N N   . ALA A 1 243 ? 90.540  116.770 99.210  1.00 96.94  ?  243 ALA A N   1 
ATOM 1756 C CA  . ALA A 1 243 ? 90.064  116.706 97.834  1.00 88.60  ?  243 ALA A CA  1 
ATOM 1757 C C   . ALA A 1 243 ? 89.537  115.359 97.427  1.00 93.27  ?  243 ALA A C   1 
ATOM 1758 O O   . ALA A 1 243 ? 88.540  115.299 96.716  1.00 96.17  ?  243 ALA A O   1 
ATOM 1759 C CB  . ALA A 1 243 ? 91.172  117.115 96.887  1.00 86.09  ?  243 ALA A CB  1 
ATOM 1760 N N   . VAL A 1 244 ? 90.192  114.283 97.857  1.00 94.81  ?  244 VAL A N   1 
ATOM 1761 C CA  . VAL A 1 244 ? 89.812  112.934 97.458  1.00 86.73  ?  244 VAL A CA  1 
ATOM 1762 C C   . VAL A 1 244 ? 89.510  112.159 98.729  1.00 82.75  ?  244 VAL A C   1 
ATOM 1763 O O   . VAL A 1 244 ? 90.366  111.468 99.253  1.00 87.85  ?  244 VAL A O   1 
ATOM 1764 C CB  . VAL A 1 244 ? 90.943  112.272 96.664  1.00 86.99  ?  244 VAL A CB  1 
ATOM 1765 C CG1 . VAL A 1 244 ? 90.496  110.926 96.117  1.00 91.47  ?  244 VAL A CG1 1 
ATOM 1766 C CG2 . VAL A 1 244 ? 91.373  113.183 95.525  1.00 85.38  ?  244 VAL A CG2 1 
ATOM 1767 N N   . PRO A 1 245 ? 88.290  112.312 99.262  1.00 81.55  ?  245 PRO A N   1 
ATOM 1768 C CA  . PRO A 1 245 ? 87.921  111.615 100.490 1.00 86.20  ?  245 PRO A CA  1 
ATOM 1769 C C   . PRO A 1 245 ? 87.834  110.089 100.375 1.00 95.03  ?  245 PRO A C   1 
ATOM 1770 O O   . PRO A 1 245 ? 88.220  109.412 101.322 1.00 90.15  ?  245 PRO A O   1 
ATOM 1771 C CB  . PRO A 1 245 ? 86.582  112.230 100.833 1.00 85.78  ?  245 PRO A CB  1 
ATOM 1772 C CG  . PRO A 1 245 ? 85.998  112.638 99.544  1.00 82.61  ?  245 PRO A CG  1 
ATOM 1773 C CD  . PRO A 1 245 ? 87.158  113.094 98.728  1.00 82.13  ?  245 PRO A CD  1 
ATOM 1774 N N   . HIS A 1 246 ? 87.351  109.554 99.256  1.00 101.45 ?  246 HIS A N   1 
ATOM 1775 C CA  . HIS A 1 246 ? 87.152  108.111 99.093  1.00 85.27  ?  246 HIS A CA  1 
ATOM 1776 C C   . HIS A 1 246 ? 88.476  107.424 99.201  1.00 84.62  ?  246 HIS A C   1 
ATOM 1777 O O   . HIS A 1 246 ? 89.457  107.942 98.710  1.00 96.48  ?  246 HIS A O   1 
ATOM 1778 C CB  . HIS A 1 246 ? 86.525  107.830 97.734  1.00 79.30  ?  246 HIS A CB  1 
ATOM 1779 C CG  . HIS A 1 246 ? 85.936  106.464 97.600  1.00 95.77  ?  246 HIS A CG  1 
ATOM 1780 N ND1 . HIS A 1 246 ? 86.672  105.371 97.206  1.00 98.82  ?  246 HIS A ND1 1 
ATOM 1781 C CD2 . HIS A 1 246 ? 84.669  106.023 97.769  1.00 100.94 ?  246 HIS A CD2 1 
ATOM 1782 C CE1 . HIS A 1 246 ? 85.891  104.307 97.167  1.00 92.63  ?  246 HIS A CE1 1 
ATOM 1783 N NE2 . HIS A 1 246 ? 84.670  104.675 97.504  1.00 97.07  ?  246 HIS A NE2 1 
ATOM 1784 N N   . TRP A 1 247 ? 88.537  106.250 99.826  1.00 70.31  ?  247 TRP A N   1 
ATOM 1785 C CA  . TRP A 1 247 ? 89.826  105.619 100.079 1.00 72.69  ?  247 TRP A CA  1 
ATOM 1786 C C   . TRP A 1 247 ? 90.502  104.999 98.886  1.00 84.44  ?  247 TRP A C   1 
ATOM 1787 O O   . TRP A 1 247 ? 91.699  105.036 98.806  1.00 88.28  ?  247 TRP A O   1 
ATOM 1788 C CB  . TRP A 1 247 ? 89.732  104.590 101.199 1.00 78.60  ?  247 TRP A CB  1 
ATOM 1789 C CG  . TRP A 1 247 ? 89.266  103.214 100.835 1.00 81.74  ?  247 TRP A CG  1 
ATOM 1790 C CD1 . TRP A 1 247 ? 87.989  102.752 100.853 1.00 83.99  ?  247 TRP A CD1 1 
ATOM 1791 C CD2 . TRP A 1 247 ? 90.087  102.107 100.449 1.00 78.27  ?  247 TRP A CD2 1 
ATOM 1792 N NE1 . TRP A 1 247 ? 87.956  101.433 100.484 1.00 84.16  ?  247 TRP A NE1 1 
ATOM 1793 C CE2 . TRP A 1 247 ? 89.234  101.014 100.229 1.00 79.28  ?  247 TRP A CE2 1 
ATOM 1794 C CE3 . TRP A 1 247 ? 91.459  101.940 100.252 1.00 77.05  ?  247 TRP A CE3 1 
ATOM 1795 C CZ2 . TRP A 1 247 ? 89.705  99.774  99.826  1.00 75.73  ?  247 TRP A CZ2 1 
ATOM 1796 C CZ3 . TRP A 1 247 ? 91.923  100.710 99.850  1.00 78.89  ?  247 TRP A CZ3 1 
ATOM 1797 C CH2 . TRP A 1 247 ? 91.051  99.643  99.641  1.00 77.16  ?  247 TRP A CH2 1 
ATOM 1798 N N   . ARG A 1 248 ? 89.754  104.364 98.000  1.00 86.69  ?  248 ARG A N   1 
ATOM 1799 C CA  . ARG A 1 248 ? 90.333  103.760 96.816  1.00 76.54  ?  248 ARG A CA  1 
ATOM 1800 C C   . ARG A 1 248 ? 90.905  104.844 95.954  1.00 81.05  ?  248 ARG A C   1 
ATOM 1801 O O   . ARG A 1 248 ? 91.966  104.674 95.392  1.00 93.86  ?  248 ARG A O   1 
ATOM 1802 C CB  . ARG A 1 248 ? 89.306  102.946 96.044  1.00 70.25  ?  248 ARG A CB  1 
ATOM 1803 C CG  . ARG A 1 248 ? 88.756  101.750 96.809  1.00 82.27  ?  248 ARG A CG  1 
ATOM 1804 C CD  . ARG A 1 248 ? 88.027  100.783 95.892  1.00 74.68  ?  248 ARG A CD  1 
ATOM 1805 N NE  . ARG A 1 248 ? 87.483  99.628  96.608  1.00 78.39  ?  248 ARG A NE  1 
ATOM 1806 C CZ  . ARG A 1 248 ? 88.180  98.562  97.016  1.00 78.70  ?  248 ARG A CZ  1 
ATOM 1807 N NH1 . ARG A 1 248 ? 89.495  98.472  96.837  1.00 83.06  1  248 ARG A NH1 1 
ATOM 1808 N NH2 . ARG A 1 248 ? 87.554  97.572  97.649  1.00 81.04  ?  248 ARG A NH2 1 
ATOM 1809 N N   . HIS A 1 249 ? 90.195  105.953 95.816  1.00 76.63  ?  249 HIS A N   1 
ATOM 1810 C CA  . HIS A 1 249 ? 90.689  107.101 95.056  1.00 72.05  ?  249 HIS A CA  1 
ATOM 1811 C C   . HIS A 1 249 ? 91.876  107.792 95.708  1.00 71.93  ?  249 HIS A C   1 
ATOM 1812 O O   . HIS A 1 249 ? 92.760  108.236 95.012  1.00 89.84  ?  249 HIS A O   1 
ATOM 1813 C CB  . HIS A 1 249 ? 89.583  108.112 94.805  1.00 77.67  ?  249 HIS A CB  1 
ATOM 1814 C CG  . HIS A 1 249 ? 88.386  107.552 94.108  1.00 90.23  ?  249 HIS A CG  1 
ATOM 1815 N ND1 . HIS A 1 249 ? 88.455  106.488 93.238  1.00 91.79  ?  249 HIS A ND1 1 
ATOM 1816 C CD2 . HIS A 1 249 ? 87.086  107.923 94.148  1.00 85.65  ?  249 HIS A CD2 1 
ATOM 1817 C CE1 . HIS A 1 249 ? 87.246  106.219 92.779  1.00 88.61  ?  249 HIS A CE1 1 
ATOM 1818 N NE2 . HIS A 1 249 ? 86.398  107.076 93.315  1.00 89.02  ?  249 HIS A NE2 1 
ATOM 1819 N N   . LEU A 1 250 ? 91.882  107.918 97.028  1.00 73.14  ?  250 LEU A N   1 
ATOM 1820 C CA  . LEU A 1 250 ? 92.992  108.550 97.751  1.00 76.03  ?  250 LEU A CA  1 
ATOM 1821 C C   . LEU A 1 250 ? 94.226  107.681 97.720  1.00 78.36  ?  250 LEU A C   1 
ATOM 1822 O O   . LEU A 1 250 ? 95.308  108.194 97.569  1.00 90.97  ?  250 LEU A O   1 
ATOM 1823 C CB  . LEU A 1 250 ? 92.610  108.825 99.207  1.00 79.94  ?  250 LEU A CB  1 
ATOM 1824 C CG  . LEU A 1 250 ? 93.594  109.408 100.218 1.00 71.42  ?  250 LEU A CG  1 
ATOM 1825 C CD1 . LEU A 1 250 ? 94.242  110.677 99.713  1.00 74.84  ?  250 LEU A CD1 1 
ATOM 1826 C CD2 . LEU A 1 250 ? 92.919  109.665 101.557 1.00 80.56  ?  250 LEU A CD2 1 
ATOM 1827 N N   . GLN A 1 251 ? 94.086  106.371 97.884  1.00 71.90  ?  251 GLN A N   1 
ATOM 1828 C CA  . GLN A 1 251 ? 95.228  105.467 97.780  1.00 65.70  ?  251 GLN A CA  1 
ATOM 1829 C C   . GLN A 1 251 ? 95.794  105.456 96.365  1.00 78.12  ?  251 GLN A C   1 
ATOM 1830 O O   . GLN A 1 251 ? 97.015  105.536 96.167  1.00 70.72  ?  251 GLN A O   1 
ATOM 1831 C CB  . GLN A 1 251 ? 94.810  104.058 98.200  1.00 67.09  ?  251 GLN A CB  1 
ATOM 1832 C CG  . GLN A 1 251 ? 95.886  103.001 98.028  1.00 80.22  ?  251 GLN A CG  1 
ATOM 1833 C CD  . GLN A 1 251 ? 96.821  102.922 99.213  1.00 88.15  ?  251 GLN A CD  1 
ATOM 1834 O OE1 . GLN A 1 251 ? 96.384  102.928 100.362 1.00 98.23  ?  251 GLN A OE1 1 
ATOM 1835 N NE2 . GLN A 1 251 ? 98.117  102.842 98.940  1.00 79.03  ?  251 GLN A NE2 1 
ATOM 1836 N N   . LEU A 1 252 ? 94.953  105.433 95.345  1.00 83.68  ?  252 LEU A N   1 
ATOM 1837 C CA  . LEU A 1 252 ? 95.457  105.523 93.974  1.00 77.68  ?  252 LEU A CA  1 
ATOM 1838 C C   . LEU A 1 252 ? 96.196  106.834 93.716  1.00 79.99  ?  252 LEU A C   1 
ATOM 1839 O O   . LEU A 1 252 ? 97.243  106.820 93.101  1.00 89.81  ?  252 LEU A O   1 
ATOM 1840 C CB  . LEU A 1 252 ? 94.329  105.354 92.967  1.00 65.64  ?  252 LEU A CB  1 
ATOM 1841 C CG  . LEU A 1 252 ? 94.646  105.357 91.479  1.00 70.76  ?  252 LEU A CG  1 
ATOM 1842 C CD1 . LEU A 1 252 ? 95.457  104.123 91.136  1.00 76.20  ?  252 LEU A CD1 1 
ATOM 1843 C CD2 . LEU A 1 252 ? 93.344  105.375 90.698  1.00 83.91  ?  252 LEU A CD2 1 
ATOM 1844 N N   . LEU A 1 253 ? 95.666  107.964 94.173  1.00 73.26  ?  253 LEU A N   1 
ATOM 1845 C CA  . LEU A 1 253 ? 96.297  109.272 93.951  1.00 70.60  ?  253 LEU A CA  1 
ATOM 1846 C C   . LEU A 1 253 ? 97.635  109.402 94.619  1.00 69.04  ?  253 LEU A C   1 
ATOM 1847 O O   . LEU A 1 253 ? 98.527  110.031 94.089  1.00 76.22  ?  253 LEU A O   1 
ATOM 1848 C CB  . LEU A 1 253 ? 95.411  110.424 94.403  1.00 73.81  ?  253 LEU A CB  1 
ATOM 1849 C CG  . LEU A 1 253 ? 95.638  111.717 93.635  1.00 79.49  ?  253 LEU A CG  1 
ATOM 1850 C CD1 . LEU A 1 253 ? 95.107  111.561 92.220  1.00 85.50  ?  253 LEU A CD1 1 
ATOM 1851 C CD2 . LEU A 1 253 ? 94.968  112.882 94.337  1.00 74.33  ?  253 LEU A CD2 1 
ATOM 1852 N N   . VAL A 1 254 ? 97.763  108.860 95.814  1.00 86.30  ?  254 VAL A N   1 
ATOM 1853 C CA  . VAL A 1 254 ? 99.021  108.905 96.534  1.00 92.73  ?  254 VAL A CA  1 
ATOM 1854 C C   . VAL A 1 254 ? 100.008 107.878 95.962  1.00 94.26  ?  254 VAL A C   1 
ATOM 1855 O O   . VAL A 1 254 ? 101.215 108.061 96.085  1.00 93.12  ?  254 VAL A O   1 
ATOM 1856 C CB  . VAL A 1 254 ? 98.787  108.726 98.050  1.00 83.46  ?  254 VAL A CB  1 
ATOM 1857 C CG1 . VAL A 1 254 ? 100.084 108.667 98.824  1.00 79.05  ?  254 VAL A CG1 1 
ATOM 1858 C CG2 . VAL A 1 254 ? 97.938  109.865 98.581  1.00 82.83  ?  254 VAL A CG2 1 
ATOM 1859 N N   . SER A 1 255 ? 99.538  106.821 95.289  1.00 92.57  ?  255 SER A N   1 
ATOM 1860 C CA  . SER A 1 255 ? 100.523 105.905 94.726  1.00 86.58  ?  255 SER A CA  1 
ATOM 1861 C C   . SER A 1 255 ? 100.783 106.120 93.239  1.00 84.19  ?  255 SER A C   1 
ATOM 1862 O O   . SER A 1 255 ? 101.735 105.540 92.707  1.00 95.34  ?  255 SER A O   1 
ATOM 1863 C CB  . SER A 1 255 ? 100.083 104.460 94.958  1.00 89.29  ?  255 SER A CB  1 
ATOM 1864 O OG  . SER A 1 255 ? 100.255 104.103 96.317  1.00 100.99 ?  255 SER A OG  1 
ATOM 1865 N N   . ALA A 1 256 ? 99.914  106.797 92.524  1.00 83.12  ?  256 ALA A N   1 
ATOM 1866 C CA  . ALA A 1 256 ? 100.119 106.919 91.094  1.00 86.02  ?  256 ALA A CA  1 
ATOM 1867 C C   . ALA A 1 256 ? 101.298 107.815 90.734  1.00 94.36  ?  256 ALA A C   1 
ATOM 1868 O O   . ALA A 1 256 ? 101.896 107.635 89.683  1.00 102.92 ?  256 ALA A O   1 
ATOM 1869 C CB  . ALA A 1 256 ? 98.856  107.411 90.422  1.00 87.26  ?  256 ALA A CB  1 
ATOM 1870 N N   . PRO A 1 257 ? 101.645 108.782 91.588  1.00 81.72  ?  257 PRO A N   1 
ATOM 1871 C CA  . PRO A 1 257 ? 102.831 109.569 91.257  1.00 85.64  ?  257 PRO A CA  1 
ATOM 1872 C C   . PRO A 1 257 ? 104.106 108.738 91.118  1.00 86.85  ?  257 PRO A C   1 
ATOM 1873 O O   . PRO A 1 257 ? 104.975 109.122 90.349  1.00 86.40  ?  257 PRO A O   1 
ATOM 1874 C CB  . PRO A 1 257 ? 102.953 110.496 92.456  1.00 84.83  ?  257 PRO A CB  1 
ATOM 1875 C CG  . PRO A 1 257 ? 101.556 110.706 92.897  1.00 81.07  ?  257 PRO A CG  1 
ATOM 1876 C CD  . PRO A 1 257 ? 100.904 109.371 92.714  1.00 72.13  ?  257 PRO A CD  1 
ATOM 1877 N N   . PHE A 1 258 ? 104.217 107.616 91.813  1.00 82.74  ?  258 PHE A N   1 
ATOM 1878 C CA  . PHE A 1 258 ? 105.448 106.826 91.796  1.00 79.29  ?  258 PHE A CA  1 
ATOM 1879 C C   . PHE A 1 258 ? 105.677 106.060 90.515  1.00 80.43  ?  258 PHE A C   1 
ATOM 1880 O O   . PHE A 1 258 ? 106.667 105.363 90.396  1.00 97.23  ?  258 PHE A O   1 
ATOM 1881 C CB  . PHE A 1 258 ? 105.466 105.852 92.968  1.00 80.35  ?  258 PHE A CB  1 
ATOM 1882 C CG  . PHE A 1 258 ? 105.737 106.497 94.292  1.00 80.99  ?  258 PHE A CG  1 
ATOM 1883 C CD1 . PHE A 1 258 ? 104.700 106.955 95.078  1.00 84.38  ?  258 PHE A CD1 1 
ATOM 1884 C CD2 . PHE A 1 258 ? 107.031 106.633 94.754  1.00 81.11  ?  258 PHE A CD2 1 
ATOM 1885 C CE1 . PHE A 1 258 ? 104.948 107.544 96.299  1.00 86.12  ?  258 PHE A CE1 1 
ATOM 1886 C CE2 . PHE A 1 258 ? 107.286 107.222 95.973  1.00 87.05  ?  258 PHE A CE2 1 
ATOM 1887 C CZ  . PHE A 1 258 ? 106.243 107.678 96.748  1.00 89.00  ?  258 PHE A CZ  1 
ATOM 1888 N N   . PHE A 1 259 ? 104.767 106.144 89.565  1.00 77.32  ?  259 PHE A N   1 
ATOM 1889 C CA  . PHE A 1 259 ? 105.000 105.515 88.283  1.00 83.07  ?  259 PHE A CA  1 
ATOM 1890 C C   . PHE A 1 259 ? 105.738 106.538 87.477  1.00 91.63  ?  259 PHE A C   1 
ATOM 1891 O O   . PHE A 1 259 ? 106.532 106.197 86.614  1.00 93.58  ?  259 PHE A O   1 
ATOM 1892 C CB  . PHE A 1 259 ? 103.704 105.180 87.578  1.00 87.19  ?  259 PHE A CB  1 
ATOM 1893 C CG  . PHE A 1 259 ? 103.109 103.864 87.976  1.00 93.35  ?  259 PHE A CG  1 
ATOM 1894 C CD1 . PHE A 1 259 ? 103.723 102.678 87.620  1.00 86.17  ?  259 PHE A CD1 1 
ATOM 1895 C CD2 . PHE A 1 259 ? 101.917 103.813 88.676  1.00 90.22  ?  259 PHE A CD2 1 
ATOM 1896 C CE1 . PHE A 1 259 ? 103.171 101.464 87.974  1.00 86.10  ?  259 PHE A CE1 1 
ATOM 1897 C CE2 . PHE A 1 259 ? 101.359 102.603 89.033  1.00 89.11  ?  259 PHE A CE2 1 
ATOM 1898 C CZ  . PHE A 1 259 ? 101.987 101.427 88.681  1.00 89.89  ?  259 PHE A CZ  1 
ATOM 1899 N N   . ALA A 1 260 ? 105.466 107.809 87.743  1.00 94.28  ?  260 ALA A N   1 
ATOM 1900 C CA  . ALA A 1 260 ? 106.166 108.896 87.052  1.00 90.23  ?  260 ALA A CA  1 
ATOM 1901 C C   . ALA A 1 260 ? 107.570 108.982 87.567  1.00 90.32  ?  260 ALA A C   1 
ATOM 1902 O O   . ALA A 1 260 ? 108.479 109.293 86.814  1.00 93.70  ?  260 ALA A O   1 
ATOM 1903 C CB  . ALA A 1 260 ? 105.469 110.217 87.268  1.00 82.02  ?  260 ALA A CB  1 
ATOM 1904 N N   . PHE A 1 261 ? 107.763 108.708 88.847  1.00 82.54  ?  261 PHE A N   1 
ATOM 1905 C CA  . PHE A 1 261 ? 109.100 108.692 89.422  1.00 83.35  ?  261 PHE A CA  1 
ATOM 1906 C C   . PHE A 1 261 ? 109.895 107.570 88.802  1.00 88.87  ?  261 PHE A C   1 
ATOM 1907 O O   . PHE A 1 261 ? 111.041 107.754 88.467  1.00 96.62  ?  261 PHE A O   1 
ATOM 1908 C CB  . PHE A 1 261 ? 109.096 108.556 90.954  1.00 85.25  ?  261 PHE A CB  1 
ATOM 1909 C CG  . PHE A 1 261 ? 108.200 109.531 91.714  1.00 83.84  ?  261 PHE A CG  1 
ATOM 1910 C CD1 . PHE A 1 261 ? 107.612 110.658 91.144  1.00 90.55  ?  261 PHE A CD1 1 
ATOM 1911 C CD2 . PHE A 1 261 ? 107.967 109.297 93.049  1.00 86.91  ?  261 PHE A CD2 1 
ATOM 1912 C CE1 . PHE A 1 261 ? 106.827 111.505 91.892  1.00 92.25  ?  261 PHE A CE1 1 
ATOM 1913 C CE2 . PHE A 1 261 ? 107.167 110.130 93.794  1.00 90.98  ?  261 PHE A CE2 1 
ATOM 1914 C CZ  . PHE A 1 261 ? 106.603 111.240 93.218  1.00 89.44  ?  261 PHE A CZ  1 
ATOM 1915 N N   . PHE A 1 262 ? 109.294 106.408 88.653  1.00 77.07  ?  262 PHE A N   1 
ATOM 1916 C CA  . PHE A 1 262 ? 109.956 105.280 88.030  1.00 79.27  ?  262 PHE A CA  1 
ATOM 1917 C C   . PHE A 1 262 ? 110.388 105.622 86.625  1.00 82.03  ?  262 PHE A C   1 
ATOM 1918 O O   . PHE A 1 262 ? 111.426 105.155 86.190  1.00 89.90  ?  262 PHE A O   1 
ATOM 1919 C CB  . PHE A 1 262 ? 109.023 104.063 88.022  1.00 87.31  ?  262 PHE A CB  1 
ATOM 1920 C CG  . PHE A 1 262 ? 109.399 102.989 87.046  1.00 88.44  ?  262 PHE A CG  1 
ATOM 1921 C CD1 . PHE A 1 262 ? 110.423 102.113 87.327  1.00 83.48  ?  262 PHE A CD1 1 
ATOM 1922 C CD2 . PHE A 1 262 ? 108.691 102.826 85.870  1.00 86.01  ?  262 PHE A CD2 1 
ATOM 1923 C CE1 . PHE A 1 262 ? 110.758 101.111 86.444  1.00 80.64  ?  262 PHE A CE1 1 
ATOM 1924 C CE2 . PHE A 1 262 ? 109.022 101.828 84.981  1.00 80.93  ?  262 PHE A CE2 1 
ATOM 1925 C CZ  . PHE A 1 262 ? 110.054 100.966 85.271  1.00 76.13  ?  262 PHE A CZ  1 
ATOM 1926 N N   . ILE A 1 263 ? 109.635 106.426 85.889  1.00 83.76  ?  263 ILE A N   1 
ATOM 1927 C CA  . ILE A 1 263 ? 109.967 106.678 84.486  1.00 82.55  ?  263 ILE A CA  1 
ATOM 1928 C C   . ILE A 1 263 ? 111.187 107.582 84.330  1.00 87.98  ?  263 ILE A C   1 
ATOM 1929 O O   . ILE A 1 263 ? 111.996 107.350 83.440  1.00 91.15  ?  263 ILE A O   1 
ATOM 1930 C CB  . ILE A 1 263 ? 108.752 107.213 83.695  1.00 81.62  ?  263 ILE A CB  1 
ATOM 1931 C CG1 . ILE A 1 263 ? 107.669 106.131 83.603  1.00 87.31  ?  263 ILE A CG1 1 
ATOM 1932 C CG2 . ILE A 1 263 ? 109.147 107.640 82.287  1.00 86.00  ?  263 ILE A CG2 1 
ATOM 1933 C CD1 . ILE A 1 263 ? 106.258 106.666 83.519  1.00 89.14  ?  263 ILE A CD1 1 
ATOM 1934 N N   . TYR A 1 264 ? 111.330 108.597 85.181  1.00 96.22  ?  264 TYR A N   1 
ATOM 1935 C CA  . TYR A 1 264 ? 112.499 109.489 85.117  1.00 99.06  ?  264 TYR A CA  1 
ATOM 1936 C C   . TYR A 1 264 ? 113.695 108.973 85.902  1.00 98.56  ?  264 TYR A C   1 
ATOM 1937 O O   . TYR A 1 264 ? 114.803 109.433 85.672  1.00 101.35 ?  264 TYR A O   1 
ATOM 1938 C CB  . TYR A 1 264 ? 112.179 110.949 85.515  1.00 90.34  ?  264 TYR A CB  1 
ATOM 1939 C CG  . TYR A 1 264 ? 111.830 111.260 86.965  1.00 93.82  ?  264 TYR A CG  1 
ATOM 1940 C CD1 . TYR A 1 264 ? 112.783 111.195 87.975  1.00 91.06  ?  264 TYR A CD1 1 
ATOM 1941 C CD2 . TYR A 1 264 ? 110.561 111.706 87.307  1.00 96.49  ?  264 TYR A CD2 1 
ATOM 1942 C CE1 . TYR A 1 264 ? 112.460 111.507 89.278  1.00 93.39  ?  264 TYR A CE1 1 
ATOM 1943 C CE2 . TYR A 1 264 ? 110.243 112.026 88.611  1.00 91.94  ?  264 TYR A CE2 1 
ATOM 1944 C CZ  . TYR A 1 264 ? 111.199 111.918 89.591  1.00 91.41  ?  264 TYR A CZ  1 
ATOM 1945 O OH  . TYR A 1 264 ? 110.906 112.226 90.896  1.00 89.21  ?  264 TYR A OH  1 
ATOM 1946 N N   . SER A 1 265 ? 113.485 108.037 86.826  1.00 84.88  ?  265 SER A N   1 
ATOM 1947 C CA  . SER A 1 265 ? 114.597 107.480 87.575  1.00 79.92  ?  265 SER A CA  1 
ATOM 1948 C C   . SER A 1 265 ? 115.537 106.692 86.719  1.00 81.64  ?  265 SER A C   1 
ATOM 1949 O O   . SER A 1 265 ? 116.611 106.337 87.175  1.00 93.05  ?  265 SER A O   1 
ATOM 1950 C CB  . SER A 1 265 ? 114.118 106.606 88.716  1.00 86.71  ?  265 SER A CB  1 
ATOM 1951 O OG  . SER A 1 265 ? 113.536 105.419 88.230  1.00 95.91  ?  265 SER A OG  1 
ATOM 1952 N N   . TRP A 1 266 ? 115.166 106.393 85.483  1.00 92.52  ?  266 TRP A N   1 
ATOM 1953 C CA  . TRP A 1 266 ? 116.160 105.698 84.674  1.00 92.92  ?  266 TRP A CA  1 
ATOM 1954 C C   . TRP A 1 266 ? 117.358 106.560 84.302  1.00 98.50  ?  266 TRP A C   1 
ATOM 1955 O O   . TRP A 1 266 ? 118.410 106.020 83.945  1.00 99.70  ?  266 TRP A O   1 
ATOM 1956 C CB  . TRP A 1 266 ? 115.508 105.153 83.404  1.00 91.58  ?  266 TRP A CB  1 
ATOM 1957 C CG  . TRP A 1 266 ? 114.568 104.021 83.647  1.00 96.74  ?  266 TRP A CG  1 
ATOM 1958 C CD1 . TRP A 1 266 ? 113.213 104.095 83.770  1.00 97.19  ?  266 TRP A CD1 1 
ATOM 1959 C CD2 . TRP A 1 266 ? 114.910 102.638 83.788  1.00 105.25 ?  266 TRP A CD2 1 
ATOM 1960 N NE1 . TRP A 1 266 ? 112.690 102.844 83.984  1.00 98.65  ?  266 TRP A NE1 1 
ATOM 1961 C CE2 . TRP A 1 266 ? 113.712 101.932 83.999  1.00 103.63 ?  266 TRP A CE2 1 
ATOM 1962 C CE3 . TRP A 1 266 ? 116.115 101.929 83.759  1.00 101.58 ?  266 TRP A CE3 1 
ATOM 1963 C CZ2 . TRP A 1 266 ? 113.682 100.552 84.180  1.00 100.80 ?  266 TRP A CZ2 1 
ATOM 1964 C CZ3 . TRP A 1 266 ? 116.083 100.560 83.938  1.00 98.87  ?  266 TRP A CZ3 1 
ATOM 1965 C CH2 . TRP A 1 266 ? 114.875 99.886  84.147  1.00 99.34  ?  266 TRP A CH2 1 
ATOM 1966 N N   . PHE A 1 267 ? 117.221 107.880 84.377  1.00 96.41  ?  267 PHE A N   1 
ATOM 1967 C CA  . PHE A 1 267 ? 118.271 108.808 83.982  1.00 96.64  ?  267 PHE A CA  1 
ATOM 1968 C C   . PHE A 1 267 ? 119.161 109.229 85.143  1.00 97.40  ?  267 PHE A C   1 
ATOM 1969 O O   . PHE A 1 267 ? 120.041 110.074 84.954  1.00 97.05  ?  267 PHE A O   1 
ATOM 1970 C CB  . PHE A 1 267 ? 117.647 110.041 83.326  1.00 94.79  ?  267 PHE A CB  1 
ATOM 1971 C CG  . PHE A 1 267 ? 116.661 109.709 82.244  1.00 92.86  ?  267 PHE A CG  1 
ATOM 1972 C CD1 . PHE A 1 267 ? 117.056 108.992 81.129  1.00 95.76  ?  267 PHE A CD1 1 
ATOM 1973 C CD2 . PHE A 1 267 ? 115.338 110.094 82.353  1.00 92.37  ?  267 PHE A CD2 1 
ATOM 1974 C CE1 . PHE A 1 267 ? 116.152 108.678 80.135  1.00 97.14  ?  267 PHE A CE1 1 
ATOM 1975 C CE2 . PHE A 1 267 ? 114.430 109.782 81.362  1.00 95.49  ?  267 PHE A CE2 1 
ATOM 1976 C CZ  . PHE A 1 267 ? 114.838 109.073 80.252  1.00 97.35  ?  267 PHE A CZ  1 
ATOM 1977 N N   . PHE A 1 268 ? 118.950 108.672 86.331  1.00 99.68  ?  268 PHE A N   1 
ATOM 1978 C CA  . PHE A 1 268 ? 119.822 108.951 87.461  1.00 99.35  ?  268 PHE A CA  1 
ATOM 1979 C C   . PHE A 1 268 ? 121.221 108.410 87.197  1.00 105.14 ?  268 PHE A C   1 
ATOM 1980 O O   . PHE A 1 268 ? 121.407 107.430 86.471  1.00 104.55 ?  268 PHE A O   1 
ATOM 1981 C CB  . PHE A 1 268 ? 119.261 108.327 88.739  1.00 98.78  ?  268 PHE A CB  1 
ATOM 1982 C CG  . PHE A 1 268 ? 118.064 109.042 89.293  1.00 102.84 ?  268 PHE A CG  1 
ATOM 1983 C CD1 . PHE A 1 268 ? 117.703 110.291 88.821  1.00 101.36 ?  268 PHE A CD1 1 
ATOM 1984 C CD2 . PHE A 1 268 ? 117.297 108.459 90.286  1.00 93.67  ?  268 PHE A CD2 1 
ATOM 1985 C CE1 . PHE A 1 268 ? 116.601 110.945 89.331  1.00 98.65  ?  268 PHE A CE1 1 
ATOM 1986 C CE2 . PHE A 1 268 ? 116.195 109.107 90.796  1.00 90.59  ?  268 PHE A CE2 1 
ATOM 1987 C CZ  . PHE A 1 268 ? 115.846 110.352 90.319  1.00 96.32  ?  268 PHE A CZ  1 
ATOM 1988 N N   . ILE A 1 269 ? 122.214 109.061 87.796  1.00 102.67 ?  269 ILE A N   1 
ATOM 1989 C CA  . ILE A 1 269 ? 123.606 108.642 87.690  1.00 96.23  ?  269 ILE A CA  1 
ATOM 1990 C C   . ILE A 1 269 ? 123.968 107.854 88.940  1.00 96.06  ?  269 ILE A C   1 
ATOM 1991 O O   . ILE A 1 269 ? 123.777 108.334 90.064  1.00 101.72 ?  269 ILE A O   1 
ATOM 1992 C CB  . ILE A 1 269 ? 124.542 109.847 87.504  1.00 92.41  ?  269 ILE A CB  1 
ATOM 1993 C CG1 . ILE A 1 269 ? 124.167 110.616 86.237  1.00 98.64  ?  269 ILE A CG1 1 
ATOM 1994 C CG2 . ILE A 1 269 ? 125.987 109.388 87.441  1.00 96.70  ?  269 ILE A CG2 1 
ATOM 1995 C CD1 . ILE A 1 269 ? 125.221 111.597 85.782  1.00 100.10 ?  269 ILE A CD1 1 
ATOM 1996 N N   . GLU A 1 270 ? 124.473 106.638 88.789  1.00 101.78 ?  270 GLU A N   1 
ATOM 1997 C CA  . GLU A 1 270 ? 124.792 105.793 89.941  1.00 104.10 ?  270 GLU A CA  1 
ATOM 1998 C C   . GLU A 1 270 ? 125.944 106.390 90.724  1.00 109.06 ?  270 GLU A C   1 
ATOM 1999 O O   . GLU A 1 270 ? 126.795 107.060 90.149  1.00 113.10 ?  270 GLU A O   1 
ATOM 2000 C CB  . GLU A 1 270 ? 125.138 104.386 89.459  1.00 103.70 ?  270 GLU A CB  1 
ATOM 2001 C CG  . GLU A 1 270 ? 125.617 103.423 90.525  1.00 100.88 ?  270 GLU A CG  1 
ATOM 2002 C CD  . GLU A 1 270 ? 124.532 103.049 91.497  1.00 107.99 ?  270 GLU A CD  1 
ATOM 2003 O OE1 . GLU A 1 270 ? 123.573 102.373 91.078  1.00 111.00 ?  270 GLU A OE1 1 
ATOM 2004 O OE2 . GLU A 1 270 ? 124.647 103.424 92.679  1.00 110.27 -1 270 GLU A OE2 1 
ATOM 2005 N N   . SER A 1 271 ? 125.953 106.195 92.046  1.00 109.48 ?  271 SER A N   1 
ATOM 2006 C CA  . SER A 1 271 ? 127.009 106.738 92.882  1.00 111.45 ?  271 SER A CA  1 
ATOM 2007 C C   . SER A 1 271 ? 128.373 106.269 92.440  1.00 113.28 ?  271 SER A C   1 
ATOM 2008 O O   . SER A 1 271 ? 128.614 105.075 92.362  1.00 120.64 ?  271 SER A O   1 
ATOM 2009 C CB  . SER A 1 271 ? 126.797 106.349 94.338  1.00 114.90 ?  271 SER A CB  1 
ATOM 2010 O OG  . SER A 1 271 ? 127.866 106.826 95.124  1.00 116.27 ?  271 SER A OG  1 
ATOM 2011 N N   . ALA A 1 272 ? 129.271 107.198 92.146  1.00 113.26 ?  272 ALA A N   1 
ATOM 2012 C CA  . ALA A 1 272 ? 130.635 106.849 91.777  1.00 114.53 ?  272 ALA A CA  1 
ATOM 2013 C C   . ALA A 1 272 ? 131.321 106.210 92.951  1.00 119.22 ?  272 ALA A C   1 
ATOM 2014 O O   . ALA A 1 272 ? 132.222 105.419 92.770  1.00 120.86 ?  272 ALA A O   1 
ATOM 2015 C CB  . ALA A 1 272 ? 131.403 108.057 91.315  1.00 125.51 ?  272 ALA A CB  1 
ATOM 2016 N N   . ARG A 1 273 ? 130.959 106.609 94.164  1.00 132.84 ?  273 ARG A N   1 
ATOM 2017 C CA  . ARG A 1 273 ? 131.529 105.991 95.363  1.00 132.29 ?  273 ARG A CA  1 
ATOM 2018 C C   . ARG A 1 273 ? 131.176 104.514 95.474  1.00 130.58 ?  273 ARG A C   1 
ATOM 2019 O O   . ARG A 1 273 ? 131.983 103.726 95.925  1.00 132.55 ?  273 ARG A O   1 
ATOM 2020 C CB  . ARG A 1 273 ? 131.071 106.683 96.642  1.00 131.95 ?  273 ARG A CB  1 
ATOM 2021 C CG  . ARG A 1 273 ? 131.295 108.179 96.696  1.00 132.62 ?  273 ARG A CG  1 
ATOM 2022 C CD  . ARG A 1 273 ? 131.213 108.670 98.127  1.00 132.14 ?  273 ARG A CD  1 
ATOM 2023 N NE  . ARG A 1 273 ? 132.356 108.213 98.919  1.00 139.92 ?  273 ARG A NE  1 
ATOM 2024 C CZ  . ARG A 1 273 ? 132.429 108.207 100.253 1.00 138.44 ?  273 ARG A CZ  1 
ATOM 2025 N NH1 . ARG A 1 273 ? 131.411 108.626 101.014 1.00 134.54 1  273 ARG A NH1 1 
ATOM 2026 N NH2 . ARG A 1 273 ? 133.540 107.760 100.842 1.00 134.26 ?  273 ARG A NH2 1 
ATOM 2027 N N   . TRP A 1 274 ? 129.955 104.139 95.124  1.00 115.05 ?  274 TRP A N   1 
ATOM 2028 C CA  . TRP A 1 274 ? 129.576 102.735 95.156  1.00 118.40 ?  274 TRP A CA  1 
ATOM 2029 C C   . TRP A 1 274 ? 130.374 101.992 94.099  1.00 120.54 ?  274 TRP A C   1 
ATOM 2030 O O   . TRP A 1 274 ? 130.734 100.860 94.282  1.00 124.35 ?  274 TRP A O   1 
ATOM 2031 C CB  . TRP A 1 274 ? 128.084 102.549 94.903  1.00 112.47 ?  274 TRP A CB  1 
ATOM 2032 C CG  . TRP A 1 274 ? 127.708 101.116 94.839  1.00 114.16 ?  274 TRP A CG  1 
ATOM 2033 C CD1 . TRP A 1 274 ? 127.663 100.240 95.877  1.00 115.37 ?  274 TRP A CD1 1 
ATOM 2034 C CD2 . TRP A 1 274 ? 127.356 100.373 93.670  1.00 113.41 ?  274 TRP A CD2 1 
ATOM 2035 N NE1 . TRP A 1 274 ? 127.293 99.002  95.432  1.00 113.63 ?  274 TRP A NE1 1 
ATOM 2036 C CE2 . TRP A 1 274 ? 127.098 99.056  94.079  1.00 114.56 ?  274 TRP A CE2 1 
ATOM 2037 C CE3 . TRP A 1 274 ? 127.227 100.696 92.319  1.00 115.15 ?  274 TRP A CE3 1 
ATOM 2038 C CZ2 . TRP A 1 274 ? 126.717 98.063  93.191  1.00 117.09 ?  274 TRP A CZ2 1 
ATOM 2039 C CZ3 . TRP A 1 274 ? 126.848 99.709  91.439  1.00 115.49 ?  274 TRP A CZ3 1 
ATOM 2040 C CH2 . TRP A 1 274 ? 126.597 98.408  91.877  1.00 113.44 ?  274 TRP A CH2 1 
ATOM 2041 N N   . HIS A 1 275 ? 130.628 102.612 92.973  1.00 114.27 ?  275 HIS A N   1 
ATOM 2042 C CA  . HIS A 1 275 ? 131.413 102.005 91.904  1.00 115.82 ?  275 HIS A CA  1 
ATOM 2043 C C   . HIS A 1 275 ? 132.854 101.780 92.342  1.00 120.22 ?  275 HIS A C   1 
ATOM 2044 O O   . HIS A 1 275 ? 133.439 100.726 92.066  1.00 119.49 ?  275 HIS A O   1 
ATOM 2045 C CB  . HIS A 1 275 ? 131.376 102.886 90.656  1.00 116.17 ?  275 HIS A CB  1 
ATOM 2046 C CG  . HIS A 1 275 ? 130.104 102.784 89.875  1.00 111.13 ?  275 HIS A CG  1 
ATOM 2047 N ND1 . HIS A 1 275 ? 129.476 101.583 89.627  1.00 116.55 ?  275 HIS A ND1 1 
ATOM 2048 C CD2 . HIS A 1 275 ? 129.357 103.734 89.266  1.00 115.36 ?  275 HIS A CD2 1 
ATOM 2049 C CE1 . HIS A 1 275 ? 128.386 101.800 88.912  1.00 119.11 ?  275 HIS A CE1 1 
ATOM 2050 N NE2 . HIS A 1 275 ? 128.294 103.096 88.675  1.00 116.15 ?  275 HIS A NE2 1 
ATOM 2051 N N   . SER A 1 276 ? 133.431 102.746 93.046  1.00 123.07 ?  276 SER A N   1 
ATOM 2052 C CA  . SER A 1 276 ? 134.810 102.617 93.481  1.00 120.63 ?  276 SER A CA  1 
ATOM 2053 C C   . SER A 1 276 ? 134.917 101.504 94.504  1.00 125.77 ?  276 SER A C   1 
ATOM 2054 O O   . SER A 1 276 ? 135.855 100.713 94.465  1.00 125.50 ?  276 SER A O   1 
ATOM 2055 C CB  . SER A 1 276 ? 135.322 103.928 94.057  1.00 120.43 ?  276 SER A CB  1 
ATOM 2056 O OG  . SER A 1 276 ? 134.872 104.128 95.382  1.00 124.01 ?  276 SER A OG  1 
ATOM 2057 N N   . SER A 1 277 ? 133.951 101.425 95.410  1.00 118.67 ?  277 SER A N   1 
ATOM 2058 C CA  . SER A 1 277 ? 133.972 100.401 96.452  1.00 117.87 ?  277 SER A CA  1 
ATOM 2059 C C   . SER A 1 277 ? 133.863 99.009  95.867  1.00 119.44 ?  277 SER A C   1 
ATOM 2060 O O   . SER A 1 277 ? 134.492 98.077  96.356  1.00 117.79 ?  277 SER A O   1 
ATOM 2061 C CB  . SER A 1 277 ? 132.831 100.624 97.438  1.00 115.57 ?  277 SER A CB  1 
ATOM 2062 O OG  . SER A 1 277 ? 131.599 100.164 96.918  1.00 112.45 ?  277 SER A OG  1 
ATOM 2063 N N   . SER A 1 278 ? 133.071 98.866  94.815  1.00 122.51 ?  278 SER A N   1 
ATOM 2064 C CA  . SER A 1 278 ? 132.885 97.567  94.178  1.00 123.10 ?  278 SER A CA  1 
ATOM 2065 C C   . SER A 1 278 ? 134.175 97.018  93.589  1.00 125.04 ?  278 SER A C   1 
ATOM 2066 O O   . SER A 1 278 ? 134.421 95.818  93.651  1.00 119.97 ?  278 SER A O   1 
ATOM 2067 C CB  . SER A 1 278 ? 131.802 97.648  93.106  1.00 115.39 ?  278 SER A CB  1 
ATOM 2068 O OG  . SER A 1 278 ? 130.552 97.992  93.674  1.00 116.79 ?  278 SER A OG  1 
ATOM 2069 N N   . GLY A 1 279 ? 135.033 97.910  93.084  1.00 131.75 ?  279 GLY A N   1 
ATOM 2070 C CA  . GLY A 1 279 ? 136.255 97.492  92.411  1.00 127.84 ?  279 GLY A CA  1 
ATOM 2071 C C   . GLY A 1 279 ? 136.236 98.002  90.988  1.00 128.71 ?  279 GLY A C   1 
ATOM 2072 O O   . GLY A 1 279 ? 137.268 97.966  90.320  1.00 125.18 ?  279 GLY A O   1 
ATOM 2073 N N   . ARG A 1 280 ? 135.079 98.470  90.518  1.00 130.39 ?  280 ARG A N   1 
ATOM 2074 C CA  . ARG A 1 280 ? 134.964 99.024  89.175  1.00 128.69 ?  280 ARG A CA  1 
ATOM 2075 C C   . ARG A 1 280 ? 135.284 100.512 89.137  1.00 130.19 ?  280 ARG A C   1 
ATOM 2076 O O   . ARG A 1 280 ? 134.369 101.331 89.189  1.00 129.01 ?  280 ARG A O   1 
ATOM 2077 C CB  . ARG A 1 280 ? 133.561 98.778  88.618  1.00 125.57 ?  280 ARG A CB  1 
ATOM 2078 C CG  . ARG A 1 280 ? 133.251 97.306  88.382  1.00 125.45 ?  280 ARG A CG  1 
ATOM 2079 C CD  . ARG A 1 280 ? 132.379 97.091  87.157  1.00 125.20 ?  280 ARG A CD  1 
ATOM 2080 N NE  . ARG A 1 280 ? 133.015 97.573  85.929  1.00 128.78 ?  280 ARG A NE  1 
ATOM 2081 C CZ  . ARG A 1 280 ? 132.448 97.596  84.720  1.00 129.65 ?  280 ARG A CZ  1 
ATOM 2082 N NH1 . ARG A 1 280 ? 131.203 97.152  84.525  1.00 130.42 1  280 ARG A NH1 1 
ATOM 2083 N NH2 . ARG A 1 280 ? 133.139 98.072  83.683  1.00 126.46 ?  280 ARG A NH2 1 
ATOM 2084 N N   . LEU A 1 281 ? 136.568 100.874 89.060  1.00 130.50 ?  281 LEU A N   1 
ATOM 2085 C CA  . LEU A 1 281 ? 136.927 102.285 88.907  1.00 129.22 ?  281 LEU A CA  1 
ATOM 2086 C C   . LEU A 1 281 ? 136.602 102.749 87.494  1.00 128.81 ?  281 LEU A C   1 
ATOM 2087 O O   . LEU A 1 281 ? 136.576 103.936 87.241  1.00 130.55 ?  281 LEU A O   1 
ATOM 2088 C CB  . LEU A 1 281 ? 138.400 102.562 89.249  1.00 129.44 ?  281 LEU A CB  1 
ATOM 2089 C CG  . LEU A 1 281 ? 138.832 102.676 90.717  1.00 130.22 ?  281 LEU A CG  1 
ATOM 2090 C CD1 . LEU A 1 281 ? 140.344 102.862 90.785  1.00 127.25 ?  281 LEU A CD1 1 
ATOM 2091 C CD2 . LEU A 1 281 ? 138.133 103.819 91.450  1.00 127.80 ?  281 LEU A CD2 1 
ATOM 2092 N N   . ASP A 1 282 ? 136.421 101.831 86.554  1.00 134.39 ?  282 ASP A N   1 
ATOM 2093 C CA  . ASP A 1 282 ? 136.008 102.210 85.202  1.00 132.12 ?  282 ASP A CA  1 
ATOM 2094 C C   . ASP A 1 282 ? 134.677 102.954 85.219  1.00 133.30 ?  282 ASP A C   1 
ATOM 2095 O O   . ASP A 1 282 ? 134.503 103.878 84.435  1.00 134.10 ?  282 ASP A O   1 
ATOM 2096 C CB  . ASP A 1 282 ? 135.855 100.973 84.318  1.00 135.24 ?  282 ASP A CB  1 
ATOM 2097 C CG  . ASP A 1 282 ? 137.171 100.244 84.078  1.00 138.40 ?  282 ASP A CG  1 
ATOM 2098 O OD1 . ASP A 1 282 ? 138.239 100.754 84.479  1.00 137.60 ?  282 ASP A OD1 1 
ATOM 2099 O OD2 . ASP A 1 282 ? 137.133 99.150  83.477  1.00 138.35 -1 282 ASP A OD2 1 
ATOM 2100 N N   . LEU A 1 283 ? 133.782 102.571 86.126  1.00 126.28 ?  283 LEU A N   1 
ATOM 2101 C CA  . LEU A 1 283 ? 132.494 103.225 86.236  1.00 124.94 ?  283 LEU A CA  1 
ATOM 2102 C C   . LEU A 1 283 ? 132.602 104.456 87.129  1.00 129.06 ?  283 LEU A C   1 
ATOM 2103 O O   . LEU A 1 283 ? 131.785 105.353 87.007  1.00 132.51 ?  283 LEU A O   1 
ATOM 2104 C CB  . LEU A 1 283 ? 131.452 102.232 86.734  1.00 124.21 ?  283 LEU A CB  1 
ATOM 2105 C CG  . LEU A 1 283 ? 131.322 100.910 85.965  1.00 126.63 ?  283 LEU A CG  1 
ATOM 2106 C CD1 . LEU A 1 283 ? 130.226 100.054 86.578  1.00 128.92 ?  283 LEU A CD1 1 
ATOM 2107 C CD2 . LEU A 1 283 ? 131.075 101.127 84.478  1.00 123.98 ?  283 LEU A CD2 1 
ATOM 2108 N N   . THR A 1 284 ? 133.560 104.508 88.048  1.00 129.02 ?  284 THR A N   1 
ATOM 2109 C CA  . THR A 1 284 ? 133.790 105.727 88.832  1.00 127.50 ?  284 THR A CA  1 
ATOM 2110 C C   . THR A 1 284 ? 134.238 106.807 87.886  1.00 126.21 ?  284 THR A C   1 
ATOM 2111 O O   . THR A 1 284 ? 133.822 107.936 88.014  1.00 130.48 ?  284 THR A O   1 
ATOM 2112 C CB  . THR A 1 284 ? 134.890 105.527 89.891  1.00 128.53 ?  284 THR A CB  1 
ATOM 2113 O OG1 . THR A 1 284 ? 134.457 104.557 90.846  1.00 135.22 ?  284 THR A OG1 1 
ATOM 2114 C CG2 . THR A 1 284 ? 135.250 106.821 90.622  1.00 122.90 ?  284 THR A CG2 1 
ATOM 2115 N N   . LEU A 1 285 ? 135.095 106.463 86.937  1.00 120.47 ?  285 LEU A N   1 
ATOM 2116 C CA  . LEU A 1 285 ? 135.604 107.432 85.979  1.00 118.01 ?  285 LEU A CA  1 
ATOM 2117 C C   . LEU A 1 285 ? 134.499 107.881 85.055  1.00 121.46 ?  285 LEU A C   1 
ATOM 2118 O O   . LEU A 1 285 ? 134.401 109.054 84.769  1.00 125.02 ?  285 LEU A O   1 
ATOM 2119 C CB  . LEU A 1 285 ? 136.727 106.824 85.140  1.00 124.94 ?  285 LEU A CB  1 
ATOM 2120 C CG  . LEU A 1 285 ? 137.453 107.686 84.106  1.00 125.53 ?  285 LEU A CG  1 
ATOM 2121 C CD1 . LEU A 1 285 ? 137.934 108.979 84.723  1.00 122.73 ?  285 LEU A CD1 1 
ATOM 2122 C CD2 . LEU A 1 285 ? 138.633 106.928 83.522  1.00 126.48 ?  285 LEU A CD2 1 
ATOM 2123 N N   . ARG A 1 286 ? 133.683 106.953 84.566  1.00 125.44 ?  286 ARG A N   1 
ATOM 2124 C CA  . ARG A 1 286 ? 132.590 107.285 83.665  1.00 126.61 ?  286 ARG A CA  1 
ATOM 2125 C C   . ARG A 1 286 ? 131.569 108.193 84.322  1.00 129.75 ?  286 ARG A C   1 
ATOM 2126 O O   . ARG A 1 286 ? 131.080 109.120 83.693  1.00 135.60 ?  286 ARG A O   1 
ATOM 2127 C CB  . ARG A 1 286 ? 131.895 106.029 83.169  1.00 125.12 ?  286 ARG A CB  1 
ATOM 2128 C CG  . ARG A 1 286 ? 132.499 105.421 81.920  1.00 128.51 ?  286 ARG A CG  1 
ATOM 2129 C CD  . ARG A 1 286 ? 131.610 104.301 81.410  1.00 133.03 ?  286 ARG A CD  1 
ATOM 2130 N NE  . ARG A 1 286 ? 132.034 103.809 80.106  1.00 135.79 ?  286 ARG A NE  1 
ATOM 2131 C CZ  . ARG A 1 286 ? 131.370 102.897 79.407  1.00 132.76 ?  286 ARG A CZ  1 
ATOM 2132 N NH1 . ARG A 1 286 ? 130.248 102.382 79.890  1.00 129.05 1  286 ARG A NH1 1 
ATOM 2133 N NH2 . ARG A 1 286 ? 131.823 102.502 78.225  1.00 132.13 ?  286 ARG A NH2 1 
ATOM 2134 N N   . ALA A 1 287 ? 131.243 107.946 85.584  1.00 110.05 ?  287 ALA A N   1 
ATOM 2135 C CA  . ALA A 1 287 ? 130.306 108.806 86.291  1.00 106.50 ?  287 ALA A CA  1 
ATOM 2136 C C   . ALA A 1 287 ? 130.900 110.180 86.515  1.00 109.80 ?  287 ALA A C   1 
ATOM 2137 O O   . ALA A 1 287 ? 130.242 111.177 86.280  1.00 111.59 ?  287 ALA A O   1 
ATOM 2138 C CB  . ALA A 1 287 ? 129.874 108.187 87.601  1.00 102.81 ?  287 ALA A CB  1 
ATOM 2139 N N   . LEU A 1 288 ? 132.149 110.241 86.950  1.00 113.13 ?  288 LEU A N   1 
ATOM 2140 C CA  . LEU A 1 288 ? 132.800 111.522 87.203  1.00 111.92 ?  288 LEU A CA  1 
ATOM 2141 C C   . LEU A 1 288 ? 132.953 112.362 85.939  1.00 114.69 ?  288 LEU A C   1 
ATOM 2142 O O   . LEU A 1 288 ? 132.835 113.576 85.997  1.00 127.14 ?  288 LEU A O   1 
ATOM 2143 C CB  . LEU A 1 288 ? 134.125 111.371 87.959  1.00 109.79 ?  288 LEU A CB  1 
ATOM 2144 C CG  . LEU A 1 288 ? 134.039 110.972 89.427  1.00 107.79 ?  288 LEU A CG  1 
ATOM 2145 C CD1 . LEU A 1 288 ? 135.441 110.857 89.994  1.00 117.16 ?  288 LEU A CD1 1 
ATOM 2146 C CD2 . LEU A 1 288 ? 133.230 111.995 90.201  1.00 106.85 ?  288 LEU A CD2 1 
ATOM 2147 N N   . GLN A 1 289 ? 133.239 111.743 84.805  1.00 113.56 ?  289 GLN A N   1 
ATOM 2148 C CA  . GLN A 1 289 ? 133.307 112.499 83.560  1.00 116.13 ?  289 GLN A CA  1 
ATOM 2149 C C   . GLN A 1 289 ? 131.930 112.967 83.092  1.00 120.92 ?  289 GLN A C   1 
ATOM 2150 O O   . GLN A 1 289 ? 131.798 114.094 82.640  1.00 122.21 ?  289 GLN A O   1 
ATOM 2151 C CB  . GLN A 1 289 ? 134.014 111.689 82.485  1.00 118.16 ?  289 GLN A CB  1 
ATOM 2152 C CG  . GLN A 1 289 ? 135.502 111.521 82.730  1.00 121.77 ?  289 GLN A CG  1 
ATOM 2153 C CD  . GLN A 1 289 ? 136.147 110.587 81.731  1.00 124.63 ?  289 GLN A CD  1 
ATOM 2154 O OE1 . GLN A 1 289 ? 135.460 109.881 80.996  1.00 125.97 ?  289 GLN A OE1 1 
ATOM 2155 N NE2 . GLN A 1 289 ? 137.473 110.573 81.701  1.00 120.70 ?  289 GLN A NE2 1 
ATOM 2156 N N   . ARG A 1 290 ? 130.913 112.117 83.164  1.00 118.82 ?  290 ARG A N   1 
ATOM 2157 C CA  . ARG A 1 290 ? 129.550 112.515 82.832  1.00 117.18 ?  290 ARG A CA  1 
ATOM 2158 C C   . ARG A 1 290 ? 129.105 113.707 83.668  1.00 118.74 ?  290 ARG A C   1 
ATOM 2159 O O   . ARG A 1 290 ? 128.497 114.650 83.148  1.00 124.87 ?  290 ARG A O   1 
ATOM 2160 C CB  . ARG A 1 290 ? 128.604 111.332 83.035  1.00 117.69 ?  290 ARG A CB  1 
ATOM 2161 C CG  . ARG A 1 290 ? 127.230 111.503 82.419  1.00 117.48 ?  290 ARG A CG  1 
ATOM 2162 C CD  . ARG A 1 290 ? 126.400 110.249 82.626  1.00 116.47 ?  290 ARG A CD  1 
ATOM 2163 N NE  . ARG A 1 290 ? 126.899 109.130 81.838  1.00 122.34 ?  290 ARG A NE  1 
ATOM 2164 C CZ  . ARG A 1 290 ? 126.351 107.923 81.821  1.00 121.44 ?  290 ARG A CZ  1 
ATOM 2165 N NH1 . ARG A 1 290 ? 125.283 107.639 82.547  1.00 121.15 1  290 ARG A NH1 1 
ATOM 2166 N NH2 . ARG A 1 290 ? 126.890 106.976 81.058  1.00 118.30 ?  290 ARG A NH2 1 
ATOM 2167 N N   . VAL A 1 291 ? 129.408 113.688 84.968  1.00 103.72 ?  291 VAL A N   1 
ATOM 2168 C CA  . VAL A 1 291 ? 129.038 114.805 85.832  1.00 102.27 ?  291 VAL A CA  1 
ATOM 2169 C C   . VAL A 1 291 ? 129.795 116.064 85.428  1.00 104.34 ?  291 VAL A C   1 
ATOM 2170 O O   . VAL A 1 291 ? 129.241 117.169 85.439  1.00 117.59 ?  291 VAL A O   1 
ATOM 2171 C CB  . VAL A 1 291 ? 129.276 114.441 87.309  1.00 101.80 ?  291 VAL A CB  1 
ATOM 2172 C CG1 . VAL A 1 291 ? 129.097 115.658 88.197  1.00 101.83 ?  291 VAL A CG1 1 
ATOM 2173 C CG2 . VAL A 1 291 ? 128.330 113.338 87.732  1.00 105.14 ?  291 VAL A CG2 1 
ATOM 2174 N N   . ALA A 1 292 ? 131.069 115.918 85.056  1.00 110.78 ?  292 ALA A N   1 
ATOM 2175 C CA  . ALA A 1 292 ? 131.841 117.068 84.596  1.00 112.62 ?  292 ALA A CA  1 
ATOM 2176 C C   . ALA A 1 292 ? 131.252 117.655 83.323  1.00 114.68 ?  292 ALA A C   1 
ATOM 2177 O O   . ALA A 1 292 ? 131.206 118.879 83.157  1.00 116.24 ?  292 ALA A O   1 
ATOM 2178 C CB  . ALA A 1 292 ? 133.297 116.668 84.378  1.00 118.16 ?  292 ALA A CB  1 
ATOM 2179 N N   . ARG A 1 293 ? 130.694 116.842 82.444  1.00 127.78 ?  293 ARG A N   1 
ATOM 2180 C CA  . ARG A 1 293 ? 130.011 117.411 81.285  1.00 130.75 ?  293 ARG A CA  1 
ATOM 2181 C C   . ARG A 1 293 ? 128.781 118.171 81.770  1.00 127.56 ?  293 ARG A C   1 
ATOM 2182 O O   . ARG A 1 293 ? 128.551 119.298 81.345  1.00 126.73 ?  293 ARG A O   1 
ATOM 2183 C CB  . ARG A 1 293 ? 129.611 116.335 80.279  1.00 131.92 ?  293 ARG A CB  1 
ATOM 2184 C CG  . ARG A 1 293 ? 130.765 115.775 79.463  1.00 131.83 ?  293 ARG A CG  1 
ATOM 2185 C CD  . ARG A 1 293 ? 130.386 114.461 78.789  1.00 131.95 ?  293 ARG A CD  1 
ATOM 2186 N NE  . ARG A 1 293 ? 130.805 113.268 79.536  1.00 133.94 ?  293 ARG A NE  1 
ATOM 2187 C CZ  . ARG A 1 293 ? 130.456 112.009 79.243  1.00 137.06 ?  293 ARG A CZ  1 
ATOM 2188 N NH1 . ARG A 1 293 ? 129.653 111.729 78.212  1.00 133.27 1  293 ARG A NH1 1 
ATOM 2189 N NH2 . ARG A 1 293 ? 130.908 111.006 80.000  1.00 135.46 ?  293 ARG A NH2 1 
ATOM 2190 N N   . ILE A 1 294 ? 127.997 117.563 82.658  1.00 112.13 ?  294 ILE A N   1 
ATOM 2191 C CA  . ILE A 1 294 ? 126.775 118.199 83.167  1.00 109.36 ?  294 ILE A CA  1 
ATOM 2192 C C   . ILE A 1 294 ? 127.041 119.477 83.970  1.00 111.00 ?  294 ILE A C   1 
ATOM 2193 O O   . ILE A 1 294 ? 126.379 120.469 83.749  1.00 114.45 ?  294 ILE A O   1 
ATOM 2194 C CB  . ILE A 1 294 ? 125.938 117.232 84.048  1.00 106.34 ?  294 ILE A CB  1 
ATOM 2195 C CG1 . ILE A 1 294 ? 125.407 116.045 83.237  1.00 109.37 ?  294 ILE A CG1 1 
ATOM 2196 C CG2 . ILE A 1 294 ? 124.764 117.965 84.699  1.00 109.12 ?  294 ILE A CG2 1 
ATOM 2197 C CD1 . ILE A 1 294 ? 125.190 114.792 84.062  1.00 107.82 ?  294 ILE A CD1 1 
ATOM 2198 N N   . ASN A 1 295 ? 128.024 119.476 84.863  1.00 114.47 ?  295 ASN A N   1 
ATOM 2199 C CA  . ASN A 1 295 ? 128.318 120.640 85.704  1.00 110.47 ?  295 ASN A CA  1 
ATOM 2200 C C   . ASN A 1 295 ? 128.987 121.727 84.891  1.00 115.74 ?  295 ASN A C   1 
ATOM 2201 O O   . ASN A 1 295 ? 129.056 122.864 85.342  1.00 119.09 ?  295 ASN A O   1 
ATOM 2202 C CB  . ASN A 1 295 ? 129.227 120.278 86.885  1.00 109.83 ?  295 ASN A CB  1 
ATOM 2203 C CG  . ASN A 1 295 ? 128.539 119.412 87.913  1.00 113.29 ?  295 ASN A CG  1 
ATOM 2204 O OD1 . ASN A 1 295 ? 127.374 119.098 87.777  1.00 111.42 ?  295 ASN A OD1 1 
ATOM 2205 N ND2 . ASN A 1 295 ? 129.264 119.017 88.945  1.00 115.27 ?  295 ASN A ND2 1 
ATOM 2206 N N   . GLY A 1 296 ? 129.521 121.406 83.717  1.00 126.76 ?  296 GLY A N   1 
ATOM 2207 C CA  . GLY A 1 296 ? 130.113 122.410 82.852  1.00 124.85 ?  296 GLY A CA  1 
ATOM 2208 C C   . GLY A 1 296 ? 131.615 122.524 82.961  1.00 126.55 ?  296 GLY A C   1 
ATOM 2209 O O   . GLY A 1 296 ? 132.215 123.247 82.169  1.00 124.27 ?  296 GLY A O   1 
ATOM 2210 N N   . LYS A 1 297 ? 132.227 121.827 83.916  1.00 135.42 ?  297 LYS A N   1 
ATOM 2211 C CA  . LYS A 1 297 ? 133.687 121.821 84.055  1.00 136.91 ?  297 LYS A CA  1 
ATOM 2212 C C   . LYS A 1 297 ? 134.212 120.654 83.227  1.00 136.04 ?  297 LYS A C   1 
ATOM 2213 O O   . LYS A 1 297 ? 134.791 119.723 83.772  1.00 133.45 ?  297 LYS A O   1 
ATOM 2214 C CB  . LYS A 1 297 ? 134.091 121.740 85.525  1.00 134.87 ?  297 LYS A CB  1 
ATOM 2215 C CG  . LYS A 1 297 ? 133.618 122.956 86.310  1.00 130.54 ?  297 LYS A CG  1 
ATOM 2216 C CD  . LYS A 1 297 ? 134.105 122.974 87.747  1.00 130.57 ?  297 LYS A CD  1 
ATOM 2217 C CE  . LYS A 1 297 ? 135.611 123.090 87.922  1.00 130.72 ?  297 LYS A CE  1 
ATOM 2218 N NZ  . LYS A 1 297 ? 136.261 124.166 87.119  1.00 133.01 1  297 LYS A NZ  1 
ATOM 2219 N N   . ARG A 1 298 ? 134.058 120.725 81.908  1.00 145.93 ?  298 ARG A N   1 
ATOM 2220 C CA  . ARG A 1 298 ? 134.430 119.612 81.024  1.00 145.56 ?  298 ARG A CA  1 
ATOM 2221 C C   . ARG A 1 298 ? 135.927 119.405 80.944  1.00 146.35 ?  298 ARG A C   1 
ATOM 2222 O O   . ARG A 1 298 ? 136.379 118.270 81.017  1.00 147.89 ?  298 ARG A O   1 
ATOM 2223 C CB  . ARG A 1 298 ? 133.881 119.848 79.615  1.00 146.16 ?  298 ARG A CB  1 
ATOM 2224 C CG  . ARG A 1 298 ? 132.395 120.187 79.575  1.00 145.36 ?  298 ARG A CG  1 
ATOM 2225 C CD  . ARG A 1 298 ? 131.674 119.532 78.410  1.00 146.44 ?  298 ARG A CD  1 
ATOM 2226 N NE  . ARG A 1 298 ? 130.220 119.633 78.547  1.00 150.36 ?  298 ARG A NE  1 
ATOM 2227 C CZ  . ARG A 1 298 ? 129.320 119.003 77.784  1.00 149.53 ?  298 ARG A CZ  1 
ATOM 2228 N NH1 . ARG A 1 298 ? 129.695 118.185 76.795  1.00 147.03 1  298 ARG A NH1 1 
ATOM 2229 N NH2 . ARG A 1 298 ? 128.019 119.181 78.021  1.00 145.79 ?  298 ARG A NH2 1 
ATOM 2230 N N   . GLU A 1 299 ? 136.699 120.469 80.749  1.00 148.30 ?  299 GLU A N   1 
ATOM 2231 C CA  . GLU A 1 299 ? 138.159 120.374 80.761  1.00 150.95 ?  299 GLU A CA  1 
ATOM 2232 C C   . GLU A 1 299 ? 138.635 119.606 81.972  1.00 148.71 ?  299 GLU A C   1 
ATOM 2233 O O   . GLU A 1 299 ? 139.400 118.663 81.836  1.00 146.16 ?  299 GLU A O   1 
ATOM 2234 C CB  . GLU A 1 299 ? 138.810 121.759 80.773  1.00 151.43 ?  299 GLU A CB  1 
ATOM 2235 C CG  . GLU A 1 299 ? 138.763 122.483 79.434  1.00 150.27 ?  299 GLU A CG  1 
ATOM 2236 C CD  . GLU A 1 299 ? 139.419 123.851 79.467  1.00 149.06 ?  299 GLU A CD  1 
ATOM 2237 O OE1 . GLU A 1 299 ? 139.979 124.237 80.515  1.00 149.02 ?  299 GLU A OE1 1 
ATOM 2238 O OE2 . GLU A 1 299 ? 139.376 124.545 78.431  1.00 147.89 -1 299 GLU A OE2 1 
ATOM 2239 N N   . GLU A 1 300 ? 138.150 119.977 83.154  1.00 145.99 ?  300 GLU A N   1 
ATOM 2240 C CA  . GLU A 1 300 ? 138.629 119.341 84.368  1.00 146.55 ?  300 GLU A CA  1 
ATOM 2241 C C   . GLU A 1 300 ? 138.257 117.855 84.376  1.00 147.25 ?  300 GLU A C   1 
ATOM 2242 O O   . GLU A 1 300 ? 138.995 117.053 84.940  1.00 145.50 ?  300 GLU A O   1 
ATOM 2243 C CB  . GLU A 1 300 ? 138.092 120.048 85.614  1.00 144.23 ?  300 GLU A CB  1 
ATOM 2244 C CG  . GLU A 1 300 ? 138.467 121.527 85.747  1.00 147.47 ?  300 GLU A CG  1 
ATOM 2245 C CD  . GLU A 1 300 ? 139.861 121.791 86.284  1.00 151.71 ?  300 GLU A CD  1 
ATOM 2246 O OE1 . GLU A 1 300 ? 140.094 122.920 86.765  1.00 151.66 ?  300 GLU A OE1 1 
ATOM 2247 O OE2 . GLU A 1 300 ? 140.726 120.899 86.239  1.00 152.18 -1 300 GLU A OE2 1 
ATOM 2248 N N   . GLY A 1 301 ? 137.131 117.471 83.764  1.00 145.42 ?  301 GLY A N   1 
ATOM 2249 C CA  . GLY A 1 301 ? 136.779 116.063 83.712  1.00 144.21 ?  301 GLY A CA  1 
ATOM 2250 C C   . GLY A 1 301 ? 137.687 115.252 82.816  1.00 145.61 ?  301 GLY A C   1 
ATOM 2251 O O   . GLY A 1 301 ? 137.997 114.107 83.116  1.00 142.83 ?  301 GLY A O   1 
ATOM 2252 N N   . ALA A 1 302 ? 138.096 115.831 81.694  1.00 154.28 ?  302 ALA A N   1 
ATOM 2253 C CA  . ALA A 1 302 ? 138.981 115.137 80.766  1.00 152.18 ?  302 ALA A CA  1 
ATOM 2254 C C   . ALA A 1 302 ? 140.291 114.830 81.459  1.00 152.47 ?  302 ALA A C   1 
ATOM 2255 O O   . ALA A 1 302 ? 140.890 113.782 81.228  1.00 151.00 ?  302 ALA A O   1 
ATOM 2256 C CB  . ALA A 1 302 ? 139.216 115.974 79.523  1.00 148.57 ?  302 ALA A CB  1 
ATOM 2257 N N   . LYS A 1 303 ? 140.740 115.744 82.311  1.00 146.01 ?  303 LYS A N   1 
ATOM 2258 C CA  . LYS A 1 303 ? 141.974 115.531 83.043  1.00 143.02 ?  303 LYS A CA  1 
ATOM 2259 C C   . LYS A 1 303 ? 141.841 114.291 83.905  1.00 144.88 ?  303 LYS A C   1 
ATOM 2260 O O   . LYS A 1 303 ? 142.808 113.553 84.065  1.00 145.08 ?  303 LYS A O   1 
ATOM 2261 C CB  . LYS A 1 303 ? 142.296 116.735 83.914  1.00 144.72 ?  303 LYS A CB  1 
ATOM 2262 C CG  . LYS A 1 303 ? 142.498 118.020 83.135  1.00 146.62 ?  303 LYS A CG  1 
ATOM 2263 C CD  . LYS A 1 303 ? 142.689 119.205 84.065  1.00 147.42 ?  303 LYS A CD  1 
ATOM 2264 C CE  . LYS A 1 303 ? 142.813 120.499 83.279  1.00 146.43 ?  303 LYS A CE  1 
ATOM 2265 N NZ  . LYS A 1 303 ? 143.036 121.670 84.170  1.00 144.00 1  303 LYS A NZ  1 
ATOM 2266 N N   . LEU A 1 304 ? 140.668 114.053 84.476  1.00 147.33 ?  304 LEU A N   1 
ATOM 2267 C CA  . LEU A 1 304 ? 140.483 112.899 85.345  1.00 146.51 ?  304 LEU A CA  1 
ATOM 2268 C C   . LEU A 1 304 ? 140.699 111.643 84.531  1.00 146.21 ?  304 LEU A C   1 
ATOM 2269 O O   . LEU A 1 304 ? 139.961 111.381 83.591  1.00 148.85 ?  304 LEU A O   1 
ATOM 2270 C CB  . LEU A 1 304 ? 139.088 112.913 85.957  1.00 145.10 ?  304 LEU A CB  1 
ATOM 2271 C CG  . LEU A 1 304 ? 138.657 111.758 86.847  1.00 146.54 ?  304 LEU A CG  1 
ATOM 2272 C CD1 . LEU A 1 304 ? 139.532 111.685 88.086  1.00 145.91 ?  304 LEU A CD1 1 
ATOM 2273 C CD2 . LEU A 1 304 ? 137.214 112.016 87.227  1.00 145.86 ?  304 LEU A CD2 1 
ATOM 2274 N N   . SER A 1 305 ? 141.707 110.830 84.854  1.00 153.62 ?  305 SER A N   1 
ATOM 2275 C CA  . SER A 1 305 ? 141.941 109.554 84.162  1.00 154.27 ?  305 SER A CA  1 
ATOM 2276 C C   . SER A 1 305 ? 142.041 108.483 85.242  1.00 155.62 ?  305 SER A C   1 
ATOM 2277 O O   . SER A 1 305 ? 141.668 108.753 86.370  1.00 157.29 ?  305 SER A O   1 
ATOM 2278 C CB  . SER A 1 305 ? 143.219 109.633 83.334  1.00 153.00 ?  305 SER A CB  1 
ATOM 2279 O OG  . SER A 1 305 ? 144.366 109.537 84.160  1.00 152.98 ?  305 SER A OG  1 
ATOM 2280 N N   . MET A 1 306 ? 142.518 107.283 84.911  1.00 152.84 ?  306 MET A N   1 
ATOM 2281 C CA  . MET A 1 306 ? 142.642 106.194 85.888  1.00 151.54 ?  306 MET A CA  1 
ATOM 2282 C C   . MET A 1 306 ? 143.913 106.291 86.722  1.00 151.42 ?  306 MET A C   1 
ATOM 2283 O O   . MET A 1 306 ? 143.955 105.738 87.790  1.00 150.02 ?  306 MET A O   1 
ATOM 2284 C CB  . MET A 1 306 ? 142.633 104.828 85.203  1.00 153.01 ?  306 MET A CB  1 
ATOM 2285 C CG  . MET A 1 306 ? 141.338 104.453 84.496  1.00 153.79 ?  306 MET A CG  1 
ATOM 2286 S SD  . MET A 1 306 ? 139.963 104.038 85.590  1.00 157.25 ?  306 MET A SD  1 
ATOM 2287 C CE  . MET A 1 306 ? 140.553 102.544 86.382  1.00 151.00 ?  306 MET A CE  1 
ATOM 2288 N N   . GLU A 1 307 ? 144.960 106.951 86.235  1.00 159.24 ?  307 GLU A N   1 
ATOM 2289 C CA  . GLU A 1 307 ? 146.176 107.153 87.033  1.00 159.22 ?  307 GLU A CA  1 
ATOM 2290 C C   . GLU A 1 307 ? 145.868 108.170 88.117  1.00 157.86 ?  307 GLU A C   1 
ATOM 2291 O O   . GLU A 1 307 ? 146.409 108.076 89.218  1.00 156.51 ?  307 GLU A O   1 
ATOM 2292 C CB  . GLU A 1 307 ? 147.320 107.670 86.160  1.00 158.86 ?  307 GLU A CB  1 
ATOM 2293 C CG  . GLU A 1 307 ? 147.792 106.690 85.091  1.00 158.63 ?  307 GLU A CG  1 
ATOM 2294 C CD  . GLU A 1 307 ? 149.002 107.186 84.318  1.00 158.76 ?  307 GLU A CD  1 
ATOM 2295 O OE1 . GLU A 1 307 ? 149.325 108.390 84.396  1.00 157.88 ?  307 GLU A OE1 1 
ATOM 2296 O OE2 . GLU A 1 307 ? 149.633 106.364 83.620  1.00 156.84 -1 307 GLU A OE2 1 
ATOM 2297 N N   . VAL A 1 308 ? 144.960 109.093 87.818  1.00 152.73 ?  308 VAL A N   1 
ATOM 2298 C CA  . VAL A 1 308 ? 144.582 110.110 88.782  1.00 152.82 ?  308 VAL A CA  1 
ATOM 2299 C C   . VAL A 1 308 ? 143.538 109.596 89.745  1.00 152.59 ?  308 VAL A C   1 
ATOM 2300 O O   . VAL A 1 308 ? 143.709 109.693 90.952  1.00 153.05 ?  308 VAL A O   1 
ATOM 2301 C CB  . VAL A 1 308 ? 144.001 111.331 88.071  1.00 154.11 ?  308 VAL A CB  1 
ATOM 2302 C CG1 . VAL A 1 308 ? 143.643 112.410 89.080  1.00 153.76 ?  308 VAL A CG1 1 
ATOM 2303 C CG2 . VAL A 1 308 ? 144.981 111.856 87.033  1.00 152.61 ?  308 VAL A CG2 1 
ATOM 2304 N N   . LEU A 1 309 ? 142.455 109.043 89.219  1.00 145.06 ?  309 LEU A N   1 
ATOM 2305 C CA  . LEU A 1 309 ? 141.372 108.570 90.070  1.00 144.07 ?  309 LEU A CA  1 
ATOM 2306 C C   . LEU A 1 309 ? 141.857 107.501 91.038  1.00 145.79 ?  309 LEU A C   1 
ATOM 2307 O O   . LEU A 1 309 ? 141.450 107.478 92.191  1.00 147.78 ?  309 LEU A O   1 
ATOM 2308 C CB  . LEU A 1 309 ? 140.222 108.032 89.219  1.00 143.93 ?  309 LEU A CB  1 
ATOM 2309 C CG  . LEU A 1 309 ? 139.038 107.433 89.967  1.00 144.50 ?  309 LEU A CG  1 
ATOM 2310 C CD1 . LEU A 1 309 ? 138.373 108.501 90.817  1.00 146.11 ?  309 LEU A CD1 1 
ATOM 2311 C CD2 . LEU A 1 309 ? 138.051 106.822 88.990  1.00 143.26 ?  309 LEU A CD2 1 
ATOM 2312 N N   . ARG A 1 310 ? 142.731 106.617 90.579  1.00 153.11 ?  310 ARG A N   1 
ATOM 2313 C CA  . ARG A 1 310 ? 143.257 105.587 91.462  1.00 153.25 ?  310 ARG A CA  1 
ATOM 2314 C C   . ARG A 1 310 ? 144.034 106.204 92.604  1.00 155.84 ?  310 ARG A C   1 
ATOM 2315 O O   . ARG A 1 310 ? 143.643 106.085 93.762  1.00 153.78 ?  310 ARG A O   1 
ATOM 2316 C CB  . ARG A 1 310 ? 144.155 104.607 90.707  1.00 154.62 ?  310 ARG A CB  1 
ATOM 2317 C CG  . ARG A 1 310 ? 143.398 103.616 89.846  1.00 156.14 ?  310 ARG A CG  1 
ATOM 2318 C CD  . ARG A 1 310 ? 144.334 102.646 89.147  1.00 157.11 ?  310 ARG A CD  1 
ATOM 2319 N NE  . ARG A 1 310 ? 143.606 101.758 88.248  1.00 158.02 ?  310 ARG A NE  1 
ATOM 2320 C CZ  . ARG A 1 310 ? 144.181 100.851 87.466  1.00 157.03 ?  310 ARG A CZ  1 
ATOM 2321 N NH1 . ARG A 1 310 ? 145.498 100.709 87.470  1.00 158.05 1  310 ARG A NH1 1 
ATOM 2322 N NH2 . ARG A 1 310 ? 143.437 100.088 86.678  1.00 152.70 ?  310 ARG A NH2 1 
ATOM 2323 N N   . ALA A 1 311 ? 145.133 106.871 92.287  1.00 162.72 ?  311 ALA A N   1 
ATOM 2324 C CA  . ALA A 1 311 ? 145.977 107.439 93.324  1.00 160.70 ?  311 ALA A CA  1 
ATOM 2325 C C   . ALA A 1 311 ? 145.174 108.306 94.273  1.00 158.90 ?  311 ALA A C   1 
ATOM 2326 O O   . ALA A 1 311 ? 145.387 108.264 95.482  1.00 158.12 ?  311 ALA A O   1 
ATOM 2327 C CB  . ALA A 1 311 ? 147.105 108.241 92.703  1.00 156.94 ?  311 ALA A CB  1 
ATOM 2328 N N   . SER A 1 312 ? 144.245 109.088 93.738  1.00 153.27 ?  312 SER A N   1 
ATOM 2329 C CA  . SER A 1 312 ? 143.466 109.995 94.572  1.00 153.20 ?  312 SER A CA  1 
ATOM 2330 C C   . SER A 1 312 ? 142.291 109.305 95.240  1.00 154.39 ?  312 SER A C   1 
ATOM 2331 O O   . SER A 1 312 ? 141.519 109.943 95.941  1.00 154.11 ?  312 SER A O   1 
ATOM 2332 C CB  . SER A 1 312 ? 142.956 111.169 93.746  1.00 151.84 ?  312 SER A CB  1 
ATOM 2333 O OG  . SER A 1 312 ? 142.128 110.722 92.691  1.00 151.44 ?  312 SER A OG  1 
ATOM 2334 N N   . LEU A 1 313 ? 142.140 108.009 95.013  1.00 159.93 ?  313 LEU A N   1 
ATOM 2335 C CA  . LEU A 1 313 ? 141.062 107.266 95.651  1.00 161.01 ?  313 LEU A CA  1 
ATOM 2336 C C   . LEU A 1 313 ? 141.611 105.993 96.265  1.00 161.65 ?  313 LEU A C   1 
ATOM 2337 O O   . LEU A 1 313 ? 140.854 105.148 96.736  1.00 162.06 ?  313 LEU A O   1 
ATOM 2338 C CB  . LEU A 1 313 ? 139.950 106.953 94.648  1.00 157.81 ?  313 LEU A CB  1 
ATOM 2339 C CG  . LEU A 1 313 ? 138.556 106.762 95.232  1.00 154.99 ?  313 LEU A CG  1 
ATOM 2340 C CD1 . LEU A 1 313 ? 138.258 107.882 96.212  1.00 158.45 ?  313 LEU A CD1 1 
ATOM 2341 C CD2 . LEU A 1 313 ? 137.521 106.728 94.121  1.00 154.76 ?  313 LEU A CD2 1 
ATOM 2342 N N   . GLN A 1 314 ? 142.931 105.860 96.278  1.00 164.78 ?  314 GLN A N   1 
ATOM 2343 C CA  . GLN A 1 314 ? 143.561 104.664 96.824  1.00 165.06 ?  314 GLN A CA  1 
ATOM 2344 C C   . GLN A 1 314 ? 143.418 104.558 98.331  1.00 166.32 ?  314 GLN A C   1 
ATOM 2345 O O   . GLN A 1 314 ? 143.150 103.481 98.859  1.00 164.76 ?  314 GLN A O   1 
ATOM 2346 C CB  . GLN A 1 314 ? 145.043 104.658 96.460  1.00 164.49 ?  314 GLN A CB  1 
ATOM 2347 C CG  . GLN A 1 314 ? 145.866 103.629 97.212  1.00 167.43 ?  314 GLN A CG  1 
ATOM 2348 C CD  . GLN A 1 314 ? 147.356 103.840 97.033  1.00 167.90 ?  314 GLN A CD  1 
ATOM 2349 O OE1 . GLN A 1 314 ? 147.784 104.770 96.350  1.00 166.54 ?  314 GLN A OE1 1 
ATOM 2350 N NE2 . GLN A 1 314 ? 148.154 102.977 97.650  1.00 166.53 ?  314 GLN A NE2 1 
ATOM 2351 N N   . LYS A 1 315 ? 143.596 105.669 99.033  1.00 169.77 ?  315 LYS A N   1 
ATOM 2352 C CA  . LYS A 1 315 ? 143.556 105.624 100.487 1.00 169.69 ?  315 LYS A CA  1 
ATOM 2353 C C   . LYS A 1 315 ? 142.209 105.096 100.937 1.00 169.30 ?  315 LYS A C   1 
ATOM 2354 O O   . LYS A 1 315 ? 142.130 104.280 101.854 1.00 169.38 ?  315 LYS A O   1 
ATOM 2355 C CB  . LYS A 1 315 ? 143.813 107.009 101.087 1.00 168.11 ?  315 LYS A CB  1 
ATOM 2356 C CG  . LYS A 1 315 ? 143.866 107.016 102.607 1.00 168.94 ?  315 LYS A CG  1 
ATOM 2357 C CD  . LYS A 1 315 ? 144.430 108.320 103.142 1.00 169.09 ?  315 LYS A CD  1 
ATOM 2358 C CE  . LYS A 1 315 ? 144.468 108.325 104.662 1.00 167.40 ?  315 LYS A CE  1 
ATOM 2359 N NZ  . LYS A 1 315 ? 145.078 109.569 105.206 1.00 165.40 1  315 LYS A NZ  1 
ATOM 2360 N N   . GLU A 1 316 ? 141.147 105.545 100.283 1.00 169.67 ?  316 GLU A N   1 
ATOM 2361 C CA  . GLU A 1 316 ? 139.816 105.084 100.643 1.00 170.39 ?  316 GLU A CA  1 
ATOM 2362 C C   . GLU A 1 316 ? 139.735 103.589 100.391 1.00 170.72 ?  316 GLU A C   1 
ATOM 2363 O O   . GLU A 1 316 ? 139.181 102.856 101.202 1.00 170.24 ?  316 GLU A O   1 
ATOM 2364 C CB  . GLU A 1 316 ? 138.735 105.816 99.838  1.00 169.25 ?  316 GLU A CB  1 
ATOM 2365 C CG  . GLU A 1 316 ? 138.752 107.337 99.966  1.00 169.14 ?  316 GLU A CG  1 
ATOM 2366 C CD  . GLU A 1 316 ? 137.410 107.988 99.672  1.00 172.59 ?  316 GLU A CD  1 
ATOM 2367 O OE1 . GLU A 1 316 ? 137.229 109.159 100.066 1.00 172.78 ?  316 GLU A OE1 1 
ATOM 2368 O OE2 . GLU A 1 316 ? 136.533 107.346 99.053  1.00 170.99 -1 316 GLU A OE2 1 
ATOM 2369 N N   . LEU A 1 317 ? 140.286 103.139 99.271  1.00 173.22 ?  317 LEU A N   1 
ATOM 2370 C CA  . LEU A 1 317 ? 140.273 101.713 98.918  1.00 174.08 ?  317 LEU A CA  1 
ATOM 2371 C C   . LEU A 1 317 ? 141.099 100.802 99.848  1.00 173.83 ?  317 LEU A C   1 
ATOM 2372 O O   . LEU A 1 317 ? 140.673 99.686  100.135 1.00 172.51 ?  317 LEU A O   1 
ATOM 2373 C CB  . LEU A 1 317 ? 140.685 101.526 97.446  1.00 172.91 ?  317 LEU A CB  1 
ATOM 2374 C CG  . LEU A 1 317 ? 139.787 102.192 96.382  1.00 172.15 ?  317 LEU A CG  1 
ATOM 2375 C CD1 . LEU A 1 317 ? 140.531 102.435 95.075  1.00 170.81 ?  317 LEU A CD1 1 
ATOM 2376 C CD2 . LEU A 1 317 ? 138.505 101.415 96.133  1.00 171.95 ?  317 LEU A CD2 1 
ATOM 2377 N N   . GLN A 1 323 ? 133.901 99.463  108.353 1.00 189.42 ?  323 GLN A N   1 
ATOM 2378 C CA  . GLN A 1 323 ? 132.842 99.299  109.350 1.00 189.32 ?  323 GLN A CA  1 
ATOM 2379 C C   . GLN A 1 323 ? 132.804 97.914  109.959 1.00 188.91 ?  323 GLN A C   1 
ATOM 2380 O O   . GLN A 1 323 ? 132.919 96.920  109.240 1.00 187.32 ?  323 GLN A O   1 
ATOM 2381 C CB  . GLN A 1 323 ? 131.462 99.604  108.757 1.00 187.39 ?  323 GLN A CB  1 
ATOM 2382 C CG  . GLN A 1 323 ? 131.205 101.063 108.409 1.00 187.62 ?  323 GLN A CG  1 
ATOM 2383 C CD  . GLN A 1 323 ? 130.003 101.232 107.495 1.00 188.05 ?  323 GLN A CD  1 
ATOM 2384 O OE1 . GLN A 1 323 ? 129.091 100.404 107.493 1.00 186.86 ?  323 GLN A OE1 1 
ATOM 2385 N NE2 . GLN A 1 323 ? 129.986 102.316 106.724 1.00 186.90 ?  323 GLN A NE2 1 
ATOM 2386 N N   . ALA A 1 324 ? 132.626 97.844  111.278 1.00 164.73 ?  324 ALA A N   1 
ATOM 2387 C CA  . ALA A 1 324 ? 132.641 96.559  111.976 1.00 161.16 ?  324 ALA A CA  1 
ATOM 2388 C C   . ALA A 1 324 ? 131.260 95.932  112.015 1.00 163.03 ?  324 ALA A C   1 
ATOM 2389 O O   . ALA A 1 324 ? 130.291 96.576  111.626 1.00 163.67 ?  324 ALA A O   1 
ATOM 2390 C CB  . ALA A 1 324 ? 133.188 96.732  113.377 1.00 158.53 ?  324 ALA A CB  1 
ATOM 2391 N N   . SER A 1 325 ? 131.156 94.685  112.477 1.00 158.38 ?  325 SER A N   1 
ATOM 2392 C CA  . SER A 1 325 ? 129.870 93.981  112.453 1.00 158.12 ?  325 SER A CA  1 
ATOM 2393 C C   . SER A 1 325 ? 128.945 94.396  113.571 1.00 156.75 ?  325 SER A C   1 
ATOM 2394 O O   . SER A 1 325 ? 129.404 94.842  114.611 1.00 155.94 ?  325 SER A O   1 
ATOM 2395 C CB  . SER A 1 325 ? 130.105 92.478  112.583 1.00 156.26 ?  325 SER A CB  1 
ATOM 2396 O OG  . SER A 1 325 ? 130.752 92.168  113.801 1.00 158.94 ?  325 SER A OG  1 
ATOM 2397 N N   . ALA A 1 326 ? 127.645 94.225  113.380 1.00 142.79 ?  326 ALA A N   1 
ATOM 2398 C CA  . ALA A 1 326 ? 126.683 94.525  114.436 1.00 140.08 ?  326 ALA A CA  1 
ATOM 2399 C C   . ALA A 1 326 ? 126.867 93.612  115.640 1.00 144.04 ?  326 ALA A C   1 
ATOM 2400 O O   . ALA A 1 326 ? 126.500 93.979  116.739 1.00 146.16 ?  326 ALA A O   1 
ATOM 2401 C CB  . ALA A 1 326 ? 125.261 94.455  113.918 1.00 138.40 ?  326 ALA A CB  1 
ATOM 2402 N N   . MET A 1 327 ? 127.484 92.448  115.472 1.00 152.02 ?  327 MET A N   1 
ATOM 2403 C CA  . MET A 1 327 ? 127.772 91.623  116.641 1.00 151.50 ?  327 MET A CA  1 
ATOM 2404 C C   . MET A 1 327 ? 128.721 92.367  117.566 1.00 152.23 ?  327 MET A C   1 
ATOM 2405 O O   . MET A 1 327 ? 128.695 92.130  118.760 1.00 152.64 ?  327 MET A O   1 
ATOM 2406 C CB  . MET A 1 327 ? 128.372 90.266  116.268 1.00 151.03 ?  327 MET A CB  1 
ATOM 2407 C CG  . MET A 1 327 ? 127.394 89.270  115.657 1.00 153.28 ?  327 MET A CG  1 
ATOM 2408 S SD  . MET A 1 327 ? 125.860 88.984  116.573 1.00 155.70 ?  327 MET A SD  1 
ATOM 2409 C CE  . MET A 1 327 ? 126.441 88.683  118.242 1.00 148.75 ?  327 MET A CE  1 
ATOM 2410 N N   . GLU A 1 328 ? 129.552 93.264  117.035 1.00 147.64 ?  328 GLU A N   1 
ATOM 2411 C CA  . GLU A 1 328 ? 130.428 94.075  117.887 1.00 148.47 ?  328 GLU A CA  1 
ATOM 2412 C C   . GLU A 1 328 ? 129.648 94.970  118.818 1.00 148.32 ?  328 GLU A C   1 
ATOM 2413 O O   . GLU A 1 328 ? 130.063 95.165  119.955 1.00 148.08 ?  328 GLU A O   1 
ATOM 2414 C CB  . GLU A 1 328 ? 131.402 94.948  117.104 1.00 150.80 ?  328 GLU A CB  1 
ATOM 2415 C CG  . GLU A 1 328 ? 132.436 94.182  116.298 1.00 154.03 ?  328 GLU A CG  1 
ATOM 2416 C CD  . GLU A 1 328 ? 133.830 94.775  116.414 1.00 156.28 ?  328 GLU A CD  1 
ATOM 2417 O OE1 . GLU A 1 328 ? 133.964 96.018  116.453 1.00 154.02 ?  328 GLU A OE1 1 
ATOM 2418 O OE2 . GLU A 1 328 ? 134.801 93.993  116.452 1.00 154.82 -1 328 GLU A OE2 1 
ATOM 2419 N N   . LEU A 1 329 ? 128.540 95.537  118.353 1.00 133.60 ?  329 LEU A N   1 
ATOM 2420 C CA  . LEU A 1 329 ? 127.819 96.464  119.202 1.00 132.40 ?  329 LEU A CA  1 
ATOM 2421 C C   . LEU A 1 329 ? 127.433 95.692  120.439 1.00 134.35 ?  329 LEU A C   1 
ATOM 2422 O O   . LEU A 1 329 ? 127.639 96.171  121.542 1.00 140.88 ?  329 LEU A O   1 
ATOM 2423 C CB  . LEU A 1 329 ? 126.559 97.011  118.522 1.00 126.27 ?  329 LEU A CB  1 
ATOM 2424 C CG  . LEU A 1 329 ? 126.691 98.081  117.436 1.00 126.06 ?  329 LEU A CG  1 
ATOM 2425 C CD1 . LEU A 1 329 ? 125.439 98.134  116.575 1.00 137.14 ?  329 LEU A CD1 1 
ATOM 2426 C CD2 . LEU A 1 329 ? 126.989 99.449  118.038 1.00 123.23 ?  329 LEU A CD2 1 
ATOM 2427 N N   . LEU A 1 330 ? 126.906 94.488  120.278 1.00 135.06 ?  330 LEU A N   1 
ATOM 2428 C CA  . LEU A 1 330 ? 126.588 93.639  121.429 1.00 134.54 ?  330 LEU A CA  1 
ATOM 2429 C C   . LEU A 1 330 ? 127.797 93.089  122.172 1.00 135.40 ?  330 LEU A C   1 
ATOM 2430 O O   . LEU A 1 330 ? 127.808 93.049  123.389 1.00 135.23 ?  330 LEU A O   1 
ATOM 2431 C CB  . LEU A 1 330 ? 125.695 92.474  121.004 1.00 135.47 ?  330 LEU A CB  1 
ATOM 2432 C CG  . LEU A 1 330 ? 124.378 92.775  120.278 1.00 137.69 ?  330 LEU A CG  1 
ATOM 2433 C CD1 . LEU A 1 330 ? 123.653 91.478  119.955 1.00 133.70 ?  330 LEU A CD1 1 
ATOM 2434 C CD2 . LEU A 1 330 ? 123.491 93.712  121.087 1.00 135.49 ?  330 LEU A CD2 1 
ATOM 2435 N N   . ARG A 1 331 ? 128.822 92.661  121.455 1.00 146.07 ?  331 ARG A N   1 
ATOM 2436 C CA  . ARG A 1 331 ? 129.974 92.013  122.092 1.00 146.02 ?  331 ARG A CA  1 
ATOM 2437 C C   . ARG A 1 331 ? 130.764 92.872  123.068 1.00 146.75 ?  331 ARG A C   1 
ATOM 2438 O O   . ARG A 1 331 ? 131.076 92.414  124.164 1.00 149.09 ?  331 ARG A O   1 
ATOM 2439 C CB  . ARG A 1 331 ? 130.920 91.531  120.987 1.00 146.88 ?  331 ARG A CB  1 
ATOM 2440 C CG  . ARG A 1 331 ? 132.217 90.853  121.413 1.00 145.66 ?  331 ARG A CG  1 
ATOM 2441 C CD  . ARG A 1 331 ? 133.263 91.027  120.324 1.00 146.94 ?  331 ARG A CD  1 
ATOM 2442 N NE  . ARG A 1 331 ? 134.537 90.393  120.660 1.00 150.83 ?  331 ARG A NE  1 
ATOM 2443 C CZ  . ARG A 1 331 ? 135.645 90.448  119.914 1.00 150.32 ?  331 ARG A CZ  1 
ATOM 2444 N NH1 . ARG A 1 331 ? 135.672 91.113  118.753 1.00 149.16 1  331 ARG A NH1 1 
ATOM 2445 N NH2 . ARG A 1 331 ? 136.749 89.827  120.333 1.00 148.29 ?  331 ARG A NH2 1 
ATOM 2446 N N   . CYS A 1 332 ? 131.068 94.112  122.702 1.00 130.06 ?  332 CYS A N   1 
ATOM 2447 C CA  . CYS A 1 332 ? 131.893 94.958  123.555 1.00 132.57 ?  332 CYS A CA  1 
ATOM 2448 C C   . CYS A 1 332 ? 131.029 95.486  124.679 1.00 136.32 ?  332 CYS A C   1 
ATOM 2449 O O   . CYS A 1 332 ? 129.920 95.907  124.416 1.00 134.52 ?  332 CYS A O   1 
ATOM 2450 C CB  . CYS A 1 332 ? 132.458 96.131  122.766 1.00 134.55 ?  332 CYS A CB  1 
ATOM 2451 S SG  . CYS A 1 332 ? 133.407 95.667  121.304 1.00 140.04 ?  332 CYS A SG  1 
ATOM 2452 N N   . PRO A 1 333 ? 131.517 95.474  125.937 1.00 135.26 ?  333 PRO A N   1 
ATOM 2453 C CA  . PRO A 1 333 ? 130.626 96.041  126.947 1.00 130.23 ?  333 PRO A CA  1 
ATOM 2454 C C   . PRO A 1 333 ? 130.454 97.549  126.783 1.00 129.82 ?  333 PRO A C   1 
ATOM 2455 O O   . PRO A 1 333 ? 129.385 98.045  127.111 1.00 131.62 ?  333 PRO A O   1 
ATOM 2456 C CB  . PRO A 1 333 ? 131.341 95.716  128.251 1.00 129.80 ?  333 PRO A CB  1 
ATOM 2457 C CG  . PRO A 1 333 ? 132.774 95.588  127.899 1.00 130.55 ?  333 PRO A CG  1 
ATOM 2458 C CD  . PRO A 1 333 ? 132.814 95.061  126.501 1.00 130.98 ?  333 PRO A CD  1 
ATOM 2459 N N   . THR A 1 334 ? 131.469 98.260  126.301 1.00 129.18 ?  334 THR A N   1 
ATOM 2460 C CA  . THR A 1 334 ? 131.413 99.701  126.111 1.00 133.60 ?  334 THR A CA  1 
ATOM 2461 C C   . THR A 1 334 ? 130.395 100.083 125.059 1.00 130.27 ?  334 THR A C   1 
ATOM 2462 O O   . THR A 1 334 ? 129.680 101.067 125.211 1.00 134.66 ?  334 THR A O   1 
ATOM 2463 C CB  . THR A 1 334 ? 132.786 100.286 125.764 1.00 132.46 ?  334 THR A CB  1 
ATOM 2464 O OG1 . THR A 1 334 ? 133.780 99.707  126.616 1.00 130.93 ?  334 THR A OG1 1 
ATOM 2465 C CG2 . THR A 1 334 ? 132.785 101.796 125.941 1.00 129.28 ?  334 THR A CG2 1 
ATOM 2466 N N   . LEU A 1 335 ? 130.351 99.337  123.966 1.00 113.02 ?  335 LEU A N   1 
ATOM 2467 C CA  . LEU A 1 335 ? 129.447 99.678  122.878 1.00 111.58 ?  335 LEU A CA  1 
ATOM 2468 C C   . LEU A 1 335 ? 128.104 99.028  123.075 1.00 115.82 ?  335 LEU A C   1 
ATOM 2469 O O   . LEU A 1 335 ? 127.141 99.403  122.431 1.00 117.77 ?  335 LEU A O   1 
ATOM 2470 C CB  . LEU A 1 335 ? 130.022 99.255  121.535 1.00 114.40 ?  335 LEU A CB  1 
ATOM 2471 C CG  . LEU A 1 335 ? 131.228 100.022 121.015 1.00 118.43 ?  335 LEU A CG  1 
ATOM 2472 C CD1 . LEU A 1 335 ? 131.742 99.370  119.744 1.00 123.32 ?  335 LEU A CD1 1 
ATOM 2473 C CD2 . LEU A 1 335 ? 130.798 101.449 120.746 1.00 115.82 ?  335 LEU A CD2 1 
ATOM 2474 N N   . ARG A 1 336 ? 128.000 98.064  123.985 1.00 117.35 ?  336 ARG A N   1 
ATOM 2475 C CA  . ARG A 1 336 ? 126.705 97.480  124.296 1.00 116.38 ?  336 ARG A CA  1 
ATOM 2476 C C   . ARG A 1 336 ? 125.931 98.447  125.147 1.00 116.44 ?  336 ARG A C   1 
ATOM 2477 O O   . ARG A 1 336 ? 124.761 98.587  124.963 1.00 115.24 ?  336 ARG A O   1 
ATOM 2478 C CB  . ARG A 1 336 ? 126.855 96.151  125.017 1.00 116.74 ?  336 ARG A CB  1 
ATOM 2479 C CG  . ARG A 1 336 ? 125.552 95.480  125.417 1.00 114.93 ?  336 ARG A CG  1 
ATOM 2480 C CD  . ARG A 1 336 ? 125.827 94.049  125.839 1.00 116.42 ?  336 ARG A CD  1 
ATOM 2481 N NE  . ARG A 1 336 ? 126.895 93.991  126.841 1.00 118.40 ?  336 ARG A NE  1 
ATOM 2482 C CZ  . ARG A 1 336 ? 127.645 92.923  127.131 1.00 118.59 ?  336 ARG A CZ  1 
ATOM 2483 N NH1 . ARG A 1 336 ? 127.475 91.753  126.511 1.00 118.71 1  336 ARG A NH1 1 
ATOM 2484 N NH2 . ARG A 1 336 ? 128.588 93.029  128.067 1.00 117.77 ?  336 ARG A NH2 1 
ATOM 2485 N N   . HIS A 1 337 ? 126.584 99.127  126.079 1.00 122.82 ?  337 HIS A N   1 
ATOM 2486 C CA  . HIS A 1 337 ? 125.908 100.121 126.909 1.00 122.67 ?  337 HIS A CA  1 
ATOM 2487 C C   . HIS A 1 337 ? 125.376 101.250 126.059 1.00 122.28 ?  337 HIS A C   1 
ATOM 2488 O O   . HIS A 1 337 ? 124.271 101.714 126.282 1.00 125.80 ?  337 HIS A O   1 
ATOM 2489 C CB  . HIS A 1 337 ? 126.861 100.681 127.960 1.00 117.39 ?  337 HIS A CB  1 
ATOM 2490 C CG  . HIS A 1 337 ? 126.324 101.866 128.698 1.00 121.75 ?  337 HIS A CG  1 
ATOM 2491 N ND1 . HIS A 1 337 ? 125.650 101.757 129.895 1.00 122.62 ?  337 HIS A ND1 1 
ATOM 2492 C CD2 . HIS A 1 337 ? 126.377 103.188 128.415 1.00 124.07 ?  337 HIS A CD2 1 
ATOM 2493 C CE1 . HIS A 1 337 ? 125.305 102.961 130.314 1.00 125.33 ?  337 HIS A CE1 1 
ATOM 2494 N NE2 . HIS A 1 337 ? 125.733 103.848 129.433 1.00 127.87 ?  337 HIS A NE2 1 
ATOM 2495 N N   . LEU A 1 338 ? 126.153 101.690 125.082 1.00 109.61 ?  338 LEU A N   1 
ATOM 2496 C CA  . LEU A 1 338 ? 125.748 102.793 124.220 1.00 104.55 ?  338 LEU A CA  1 
ATOM 2497 C C   . LEU A 1 338 ? 124.675 102.278 123.281 1.00 105.29 ?  338 LEU A C   1 
ATOM 2498 O O   . LEU A 1 338 ? 123.771 103.018 122.942 1.00 111.91 ?  338 LEU A O   1 
ATOM 2499 C CB  . LEU A 1 338 ? 126.950 103.334 123.443 1.00 101.45 ?  338 LEU A CB  1 
ATOM 2500 C CG  . LEU A 1 338 ? 126.927 104.767 122.917 1.00 102.07 ?  338 LEU A CG  1 
ATOM 2501 C CD1 . LEU A 1 338 ? 127.107 105.745 124.072 1.00 107.25 ?  338 LEU A CD1 1 
ATOM 2502 C CD2 . LEU A 1 338 ? 128.022 104.970 121.871 1.00 106.59 ?  338 LEU A CD2 1 
ATOM 2503 N N   . PHE A 1 339 ? 124.760 101.019 122.857 1.00 96.14  ?  339 PHE A N   1 
ATOM 2504 C CA  . PHE A 1 339 ? 123.713 100.419 122.025 1.00 98.45  ?  339 PHE A CA  1 
ATOM 2505 C C   . PHE A 1 339 ? 122.388 100.337 122.746 1.00 105.70 ?  339 PHE A C   1 
ATOM 2506 O O   . PHE A 1 339 ? 121.451 100.918 122.291 1.00 109.24 ?  339 PHE A O   1 
ATOM 2507 C CB  . PHE A 1 339 ? 124.123 99.032  121.535 1.00 102.25 ?  339 PHE A CB  1 
ATOM 2508 C CG  . PHE A 1 339 ? 123.002 98.237  120.940 1.00 105.72 ?  339 PHE A CG  1 
ATOM 2509 C CD1 . PHE A 1 339 ? 122.513 98.537  119.685 1.00 101.84 ?  339 PHE A CD1 1 
ATOM 2510 C CD2 . PHE A 1 339 ? 122.454 97.169  121.630 1.00 111.22 ?  339 PHE A CD2 1 
ATOM 2511 C CE1 . PHE A 1 339 ? 121.489 97.798  119.136 1.00 104.37 ?  339 PHE A CE1 1 
ATOM 2512 C CE2 . PHE A 1 339 ? 121.427 96.430  121.086 1.00 104.66 ?  339 PHE A CE2 1 
ATOM 2513 C CZ  . PHE A 1 339 ? 120.944 96.745  119.836 1.00 105.91 ?  339 PHE A CZ  1 
ATOM 2514 N N   . LEU A 1 340 ? 122.307 99.638  123.867 1.00 104.42 ?  340 LEU A N   1 
ATOM 2515 C CA  . LEU A 1 340 ? 121.078 99.482  124.624 1.00 100.55 ?  340 LEU A CA  1 
ATOM 2516 C C   . LEU A 1 340 ? 120.446 100.838 124.907 1.00 100.74 ?  340 LEU A C   1 
ATOM 2517 O O   . LEU A 1 340 ? 119.256 101.008 124.693 1.00 106.84 ?  340 LEU A O   1 
ATOM 2518 C CB  . LEU A 1 340 ? 121.312 98.698  125.909 1.00 98.75  ?  340 LEU A CB  1 
ATOM 2519 C CG  . LEU A 1 340 ? 121.841 97.277  125.734 1.00 97.16  ?  340 LEU A CG  1 
ATOM 2520 C CD1 . LEU A 1 340 ? 122.153 96.651  127.082 1.00 94.40  ?  340 LEU A CD1 1 
ATOM 2521 C CD2 . LEU A 1 340 ? 120.848 96.429  124.959 1.00 98.88  ?  340 LEU A CD2 1 
ATOM 2522 N N   . CYS A 1 341 ? 121.214 101.778 125.456 1.00 93.85  ?  341 CYS A N   1 
ATOM 2523 C CA  . CYS A 1 341 ? 120.649 103.061 125.841 1.00 87.92  ?  341 CYS A CA  1 
ATOM 2524 C C   . CYS A 1 341 ? 120.043 103.740 124.656 1.00 94.29  ?  341 CYS A C   1 
ATOM 2525 O O   . CYS A 1 341 ? 118.915 104.183 124.732 1.00 103.68 ?  341 CYS A O   1 
ATOM 2526 C CB  . CYS A 1 341 ? 121.689 103.955 126.486 1.00 91.68  ?  341 CYS A CB  1 
ATOM 2527 S SG  . CYS A 1 341 ? 122.223 103.406 128.113 1.00 106.00 ?  341 CYS A SG  1 
ATOM 2528 N N   . LEU A 1 342 ? 120.773 103.811 123.553 1.00 97.13  ?  342 LEU A N   1 
ATOM 2529 C CA  . LEU A 1 342 ? 120.275 104.501 122.365 1.00 97.06  ?  342 LEU A CA  1 
ATOM 2530 C C   . LEU A 1 342 ? 119.105 103.756 121.743 1.00 98.07  ?  342 LEU A C   1 
ATOM 2531 O O   . LEU A 1 342 ? 118.203 104.387 121.267 1.00 102.63 ?  342 LEU A O   1 
ATOM 2532 C CB  . LEU A 1 342 ? 121.373 104.753 121.328 1.00 99.80  ?  342 LEU A CB  1 
ATOM 2533 C CG  . LEU A 1 342 ? 122.366 105.879 121.640 1.00 98.46  ?  342 LEU A CG  1 
ATOM 2534 C CD1 . LEU A 1 342 ? 123.653 105.714 120.846 1.00 98.61  ?  342 LEU A CD1 1 
ATOM 2535 C CD2 . LEU A 1 342 ? 121.735 107.236 121.369 1.00 95.59  ?  342 LEU A CD2 1 
ATOM 2536 N N   . SER A 1 343 ? 119.084 102.432 121.777 1.00 97.24  ?  343 SER A N   1 
ATOM 2537 C CA  . SER A 1 343 ? 117.955 101.676 121.272 1.00 98.03  ?  343 SER A CA  1 
ATOM 2538 C C   . SER A 1 343 ? 116.690 102.015 122.031 1.00 100.30 ?  343 SER A C   1 
ATOM 2539 O O   . SER A 1 343 ? 115.636 102.143 121.437 1.00 108.17 ?  343 SER A O   1 
ATOM 2540 C CB  . SER A 1 343 ? 118.235 100.189 121.362 1.00 100.89 ?  343 SER A CB  1 
ATOM 2541 O OG  . SER A 1 343 ? 119.321 99.835  120.530 1.00 103.39 ?  343 SER A OG  1 
ATOM 2542 N N   . MET A 1 344 ? 116.769 102.218 123.336 1.00 103.15 ?  344 MET A N   1 
ATOM 2543 C CA  . MET A 1 344 ? 115.584 102.631 124.075 1.00 100.78 ?  344 MET A CA  1 
ATOM 2544 C C   . MET A 1 344 ? 115.162 104.021 123.656 1.00 100.90 ?  344 MET A C   1 
ATOM 2545 O O   . MET A 1 344 ? 113.983 104.300 123.600 1.00 109.15 ?  344 MET A O   1 
ATOM 2546 C CB  . MET A 1 344 ? 115.801 102.556 125.582 1.00 97.96  ?  344 MET A CB  1 
ATOM 2547 C CG  . MET A 1 344 ? 116.217 101.177 126.063 1.00 101.90 ?  344 MET A CG  1 
ATOM 2548 S SD  . MET A 1 344 ? 116.573 101.100 127.826 1.00 121.49 ?  344 MET A SD  1 
ATOM 2549 C CE  . MET A 1 344 ? 117.417 99.525  127.941 1.00 102.64 ?  344 MET A CE  1 
ATOM 2550 N N   . LEU A 1 345 ? 116.111 104.903 123.383 1.00 91.15  ?  345 LEU A N   1 
ATOM 2551 C CA  . LEU A 1 345 ? 115.789 106.249 122.911 1.00 93.97  ?  345 LEU A CA  1 
ATOM 2552 C C   . LEU A 1 345 ? 115.144 106.278 121.540 1.00 89.87  ?  345 LEU A C   1 
ATOM 2553 O O   . LEU A 1 345 ? 114.276 107.088 121.298 1.00 94.08  ?  345 LEU A O   1 
ATOM 2554 C CB  . LEU A 1 345 ? 117.003 107.167 122.945 1.00 90.05  ?  345 LEU A CB  1 
ATOM 2555 C CG  . LEU A 1 345 ? 117.654 107.377 124.302 1.00 91.76  ?  345 LEU A CG  1 
ATOM 2556 C CD1 . LEU A 1 345 ? 118.689 108.481 124.228 1.00 92.69  ?  345 LEU A CD1 1 
ATOM 2557 C CD2 . LEU A 1 345 ? 116.579 107.735 125.297 1.00 91.52  ?  345 LEU A CD2 1 
ATOM 2558 N N   . TRP A 1 346 ? 115.586 105.426 120.630 1.00 92.41  ?  346 TRP A N   1 
ATOM 2559 C CA  . TRP A 1 346 ? 115.002 105.366 119.302 1.00 90.21  ?  346 TRP A CA  1 
ATOM 2560 C C   . TRP A 1 346 ? 113.676 104.640 119.315 1.00 91.65  ?  346 TRP A C   1 
ATOM 2561 O O   . TRP A 1 346 ? 112.748 105.050 118.641 1.00 98.05  ?  346 TRP A O   1 
ATOM 2562 C CB  . TRP A 1 346 ? 115.921 104.632 118.347 1.00 92.92  ?  346 TRP A CB  1 
ATOM 2563 C CG  . TRP A 1 346 ? 117.059 105.411 117.764 1.00 93.95  ?  346 TRP A CG  1 
ATOM 2564 C CD1 . TRP A 1 346 ? 118.335 105.475 118.235 1.00 92.86  ?  346 TRP A CD1 1 
ATOM 2565 C CD2 . TRP A 1 346 ? 117.039 106.185 116.561 1.00 97.75  ?  346 TRP A CD2 1 
ATOM 2566 N NE1 . TRP A 1 346 ? 119.105 106.258 117.416 1.00 96.85  ?  346 TRP A NE1 1 
ATOM 2567 C CE2 . TRP A 1 346 ? 118.332 106.706 116.379 1.00 98.65  ?  346 TRP A CE2 1 
ATOM 2568 C CE3 . TRP A 1 346 ? 116.050 106.499 115.627 1.00 99.05  ?  346 TRP A CE3 1 
ATOM 2569 C CZ2 . TRP A 1 346 ? 118.660 107.523 115.304 1.00 93.77  ?  346 TRP A CZ2 1 
ATOM 2570 C CZ3 . TRP A 1 346 ? 116.378 107.308 114.561 1.00 98.79  ?  346 TRP A CZ3 1 
ATOM 2571 C CH2 . TRP A 1 346 ? 117.671 107.812 114.408 1.00 95.70  ?  346 TRP A CH2 1 
ATOM 2572 N N   . PHE A 1 347 ? 113.542 103.560 120.067 1.00 89.95  ?  347 PHE A N   1 
ATOM 2573 C CA  . PHE A 1 347 ? 112.249 102.892 120.173 1.00 85.21  ?  347 PHE A CA  1 
ATOM 2574 C C   . PHE A 1 347 ? 111.257 103.855 120.759 1.00 90.13  ?  347 PHE A C   1 
ATOM 2575 O O   . PHE A 1 347 ? 110.267 104.164 120.131 1.00 98.78  ?  347 PHE A O   1 
ATOM 2576 C CB  . PHE A 1 347 ? 112.345 101.657 121.062 1.00 83.48  ?  347 PHE A CB  1 
ATOM 2577 C CG  . PHE A 1 347 ? 111.063 100.889 121.197 1.00 85.20  ?  347 PHE A CG  1 
ATOM 2578 C CD1 . PHE A 1 347 ? 110.759 99.875  120.314 1.00 90.65  ?  347 PHE A CD1 1 
ATOM 2579 C CD2 . PHE A 1 347 ? 110.180 101.157 122.228 1.00 91.49  ?  347 PHE A CD2 1 
ATOM 2580 C CE1 . PHE A 1 347 ? 109.588 99.158  120.441 1.00 91.39  ?  347 PHE A CE1 1 
ATOM 2581 C CE2 . PHE A 1 347 ? 109.006 100.449 122.357 1.00 94.50  ?  347 PHE A CE2 1 
ATOM 2582 C CZ  . PHE A 1 347 ? 108.710 99.447  121.461 1.00 90.32  ?  347 PHE A CZ  1 
ATOM 2583 N N   . ALA A 1 348 ? 111.539 104.434 121.921 1.00 88.77  ?  348 ALA A N   1 
ATOM 2584 C CA  . ALA A 1 348 ? 110.583 105.313 122.584 1.00 83.16  ?  348 ALA A CA  1 
ATOM 2585 C C   . ALA A 1 348 ? 110.082 106.448 121.727 1.00 82.18  ?  348 ALA A C   1 
ATOM 2586 O O   . ALA A 1 348 ? 108.892 106.714 121.705 1.00 93.16  ?  348 ALA A O   1 
ATOM 2587 C CB  . ALA A 1 348 ? 111.176 105.875 123.848 1.00 81.48  ?  348 ALA A CB  1 
ATOM 2588 N N   . THR A 1 349 ? 110.975 107.142 121.040 1.00 86.18  ?  349 THR A N   1 
ATOM 2589 C CA  . THR A 1 349 ? 110.556 108.294 120.258 1.00 79.27  ?  349 THR A CA  1 
ATOM 2590 C C   . THR A 1 349 ? 109.615 107.865 119.155 1.00 78.61  ?  349 THR A C   1 
ATOM 2591 O O   . THR A 1 349 ? 108.577 108.461 118.985 1.00 90.89  ?  349 THR A O   1 
ATOM 2592 C CB  . THR A 1 349 ? 111.740 109.047 119.613 1.00 90.21  ?  349 THR A CB  1 
ATOM 2593 O OG1 . THR A 1 349 ? 112.674 109.465 120.614 1.00 96.41  ?  349 THR A OG1 1 
ATOM 2594 C CG2 . THR A 1 349 ? 111.258 110.277 118.881 1.00 84.42  ?  349 THR A CG2 1 
ATOM 2595 N N   . SER A 1 350 ? 109.948 106.809 118.428 1.00 87.59  ?  350 SER A N   1 
ATOM 2596 C CA  . SER A 1 350 ? 109.075 106.305 117.369 1.00 89.40  ?  350 SER A CA  1 
ATOM 2597 C C   . SER A 1 350 ? 107.779 105.734 117.869 1.00 84.47  ?  350 SER A C   1 
ATOM 2598 O O   . SER A 1 350 ? 106.736 105.982 117.299 1.00 92.30  ?  350 SER A O   1 
ATOM 2599 C CB  . SER A 1 350 ? 109.773 105.254 116.532 1.00 95.36  ?  350 SER A CB  1 
ATOM 2600 O OG  . SER A 1 350 ? 108.980 104.952 115.402 1.00 103.64 ?  350 SER A OG  1 
ATOM 2601 N N   . PHE A 1 351 ? 107.835 104.980 118.944 1.00 83.04  ?  351 PHE A N   1 
ATOM 2602 C CA  . PHE A 1 351 ? 106.648 104.342 119.472 1.00 77.54  ?  351 PHE A CA  1 
ATOM 2603 C C   . PHE A 1 351 ? 105.655 105.393 119.890 1.00 81.46  ?  351 PHE A C   1 
ATOM 2604 O O   . PHE A 1 351 ? 104.494 105.324 119.514 1.00 91.75  ?  351 PHE A O   1 
ATOM 2605 C CB  . PHE A 1 351 ? 107.075 103.473 120.658 1.00 84.43  ?  351 PHE A CB  1 
ATOM 2606 C CG  . PHE A 1 351 ? 105.955 102.951 121.485 1.00 86.16  ?  351 PHE A CG  1 
ATOM 2607 C CD1 . PHE A 1 351 ? 105.176 101.910 121.036 1.00 91.44  ?  351 PHE A CD1 1 
ATOM 2608 C CD2 . PHE A 1 351 ? 105.726 103.464 122.747 1.00 88.08  ?  351 PHE A CD2 1 
ATOM 2609 C CE1 . PHE A 1 351 ? 104.159 101.415 121.814 1.00 89.77  ?  351 PHE A CE1 1 
ATOM 2610 C CE2 . PHE A 1 351 ? 104.715 102.970 123.529 1.00 89.19  ?  351 PHE A CE2 1 
ATOM 2611 C CZ  . PHE A 1 351 ? 103.929 101.946 123.062 1.00 87.85  ?  351 PHE A CZ  1 
ATOM 2612 N N   . ALA A 1 352 ? 106.111 106.401 120.616 1.00 81.83  ?  352 ALA A N   1 
ATOM 2613 C CA  . ALA A 1 352 ? 105.240 107.492 121.029 1.00 75.89  ?  352 ALA A CA  1 
ATOM 2614 C C   . ALA A 1 352 ? 104.795 108.368 119.896 1.00 82.33  ?  352 ALA A C   1 
ATOM 2615 O O   . ALA A 1 352 ? 103.670 108.817 119.888 1.00 87.40  ?  352 ALA A O   1 
ATOM 2616 C CB  . ALA A 1 352 ? 105.897 108.320 122.090 1.00 76.33  ?  352 ALA A CB  1 
ATOM 2617 N N   . TYR A 1 353 ? 105.689 108.657 118.962 1.00 88.29  ?  353 TYR A N   1 
ATOM 2618 C CA  . TYR A 1 353 ? 105.368 109.540 117.852 1.00 82.83  ?  353 TYR A CA  1 
ATOM 2619 C C   . TYR A 1 353 ? 104.302 108.972 116.990 1.00 90.22  ?  353 TYR A C   1 
ATOM 2620 O O   . TYR A 1 353 ? 103.391 109.674 116.630 1.00 96.73  ?  353 TYR A O   1 
ATOM 2621 C CB  . TYR A 1 353 ? 106.596 109.780 116.990 1.00 76.89  ?  353 TYR A CB  1 
ATOM 2622 C CG  . TYR A 1 353 ? 106.370 110.639 115.780 1.00 79.74  ?  353 TYR A CG  1 
ATOM 2623 C CD1 . TYR A 1 353 ? 106.355 112.019 115.887 1.00 87.65  ?  353 TYR A CD1 1 
ATOM 2624 C CD2 . TYR A 1 353 ? 106.220 110.075 114.523 1.00 88.86  ?  353 TYR A CD2 1 
ATOM 2625 C CE1 . TYR A 1 353 ? 106.176 112.813 114.780 1.00 93.79  ?  353 TYR A CE1 1 
ATOM 2626 C CE2 . TYR A 1 353 ? 106.034 110.862 113.410 1.00 92.47  ?  353 TYR A CE2 1 
ATOM 2627 C CZ  . TYR A 1 353 ? 106.015 112.231 113.544 1.00 95.19  ?  353 TYR A CZ  1 
ATOM 2628 O OH  . TYR A 1 353 ? 105.825 113.019 112.438 1.00 91.98  ?  353 TYR A OH  1 
ATOM 2629 N N   . TYR A 1 354 ? 104.410 107.700 116.646 1.00 94.16  ?  354 TYR A N   1 
ATOM 2630 C CA  . TYR A 1 354 ? 103.380 107.055 115.855 1.00 91.12  ?  354 TYR A CA  1 
ATOM 2631 C C   . TYR A 1 354 ? 102.109 106.899 116.636 1.00 86.64  ?  354 TYR A C   1 
ATOM 2632 O O   . TYR A 1 354 ? 101.043 107.030 116.096 1.00 99.07  ?  354 TYR A O   1 
ATOM 2633 C CB  . TYR A 1 354 ? 103.855 105.770 115.198 1.00 88.02  ?  354 TYR A CB  1 
ATOM 2634 C CG  . TYR A 1 354 ? 104.649 106.069 113.952 1.00 94.59  ?  354 TYR A CG  1 
ATOM 2635 C CD1 . TYR A 1 354 ? 104.010 106.404 112.765 1.00 92.68  ?  354 TYR A CD1 1 
ATOM 2636 C CD2 . TYR A 1 354 ? 106.032 106.060 113.966 1.00 93.51  ?  354 TYR A CD2 1 
ATOM 2637 C CE1 . TYR A 1 354 ? 104.729 106.702 111.628 1.00 91.35  ?  354 TYR A CE1 1 
ATOM 2638 C CE2 . TYR A 1 354 ? 106.758 106.352 112.835 1.00 99.24  ?  354 TYR A CE2 1 
ATOM 2639 C CZ  . TYR A 1 354 ? 106.101 106.672 111.670 1.00 101.12 ?  354 TYR A CZ  1 
ATOM 2640 O OH  . TYR A 1 354 ? 106.826 106.962 110.544 1.00 100.48 ?  354 TYR A OH  1 
ATOM 2641 N N   . GLY A 1 355 ? 102.205 106.608 117.910 1.00 81.62  ?  355 GLY A N   1 
ATOM 2642 C CA  . GLY A 1 355 ? 101.017 106.535 118.723 1.00 86.04  ?  355 GLY A CA  1 
ATOM 2643 C C   . GLY A 1 355 ? 100.211 107.808 118.627 1.00 89.20  ?  355 GLY A C   1 
ATOM 2644 O O   . GLY A 1 355 ? 99.014  107.740 118.388 1.00 94.78  ?  355 GLY A O   1 
ATOM 2645 N N   . LEU A 1 356 ? 100.844 108.963 118.834 1.00 85.71  ?  356 LEU A N   1 
ATOM 2646 C CA  . LEU A 1 356 ? 100.152 110.250 118.740 1.00 88.52  ?  356 LEU A CA  1 
ATOM 2647 C C   . LEU A 1 356 ? 99.693  110.630 117.338 1.00 95.11  ?  356 LEU A C   1 
ATOM 2648 O O   . LEU A 1 356 ? 98.574  111.094 117.159 1.00 95.09  ?  356 LEU A O   1 
ATOM 2649 C CB  . LEU A 1 356 ? 101.063 111.348 119.285 1.00 88.60  ?  356 LEU A CB  1 
ATOM 2650 C CG  . LEU A 1 356 ? 100.442 112.491 120.072 1.00 88.73  ?  356 LEU A CG  1 
ATOM 2651 C CD1 . LEU A 1 356 ? 99.564  111.935 121.180 1.00 91.45  ?  356 LEU A CD1 1 
ATOM 2652 C CD2 . LEU A 1 356 ? 101.564 113.330 120.650 1.00 91.70  ?  356 LEU A CD2 1 
ATOM 2653 N N   . VAL A 1 357 ? 100.555 110.454 116.332 1.00 99.68  ?  357 VAL A N   1 
ATOM 2654 C CA  . VAL A 1 357 ? 100.246 110.856 114.953 1.00 92.46  ?  357 VAL A CA  1 
ATOM 2655 C C   . VAL A 1 357 ? 99.152  110.002 114.344 1.00 97.60  ?  357 VAL A C   1 
ATOM 2656 O O   . VAL A 1 357 ? 98.418  110.484 113.489 1.00 102.44 ?  357 VAL A O   1 
ATOM 2657 C CB  . VAL A 1 357 ? 101.524 110.820 114.068 1.00 86.01  ?  357 VAL A CB  1 
ATOM 2658 C CG1 . VAL A 1 357 ? 101.209 110.972 112.588 1.00 97.26  ?  357 VAL A CG1 1 
ATOM 2659 C CG2 . VAL A 1 357 ? 102.494 111.917 114.488 1.00 93.69  ?  357 VAL A CG2 1 
ATOM 2660 N N   . MET A 1 358 ? 98.984  108.774 114.818 1.00 101.23 ?  358 MET A N   1 
ATOM 2661 C CA  . MET A 1 358 ? 98.004  107.849 114.245 1.00 96.24  ?  358 MET A CA  1 
ATOM 2662 C C   . MET A 1 358 ? 96.646  107.885 114.930 1.00 103.96 ?  358 MET A C   1 
ATOM 2663 O O   . MET A 1 358 ? 95.841  106.988 114.707 1.00 110.20 ?  358 MET A O   1 
ATOM 2664 C CB  . MET A 1 358 ? 98.557  106.420 114.166 1.00 99.98  ?  358 MET A CB  1 
ATOM 2665 C CG  . MET A 1 358 ? 99.775  106.248 113.261 1.00 109.24 ?  358 MET A CG  1 
ATOM 2666 S SD  . MET A 1 358 ? 99.613  106.877 111.581 1.00 119.18 ?  358 MET A SD  1 
ATOM 2667 C CE  . MET A 1 358 ? 98.260  105.907 110.927 1.00 101.40 ?  358 MET A CE  1 
ATOM 2668 N N   . ASP A 1 359 ? 96.388  108.877 115.780 1.00 118.00 ?  359 ASP A N   1 
ATOM 2669 C CA  . ASP A 1 359 ? 95.065  109.040 116.397 1.00 117.86 ?  359 ASP A CA  1 
ATOM 2670 C C   . ASP A 1 359 ? 94.622  110.493 116.256 1.00 118.05 ?  359 ASP A C   1 
ATOM 2671 O O   . ASP A 1 359 ? 94.603  111.222 117.237 1.00 120.00 ?  359 ASP A O   1 
ATOM 2672 C CB  . ASP A 1 359 ? 95.091  108.599 117.857 1.00 120.50 ?  359 ASP A CB  1 
ATOM 2673 C CG  . ASP A 1 359 ? 93.713  108.612 118.513 1.00 126.36 ?  359 ASP A CG  1 
ATOM 2674 O OD1 . ASP A 1 359 ? 92.686  108.637 117.803 1.00 121.78 ?  359 ASP A OD1 1 
ATOM 2675 O OD2 . ASP A 1 359 ? 93.662  108.582 119.759 1.00 131.69 -1 359 ASP A OD2 1 
ATOM 2676 N N   . LEU A 1 360 ? 94.212  110.902 115.054 1.00 102.79 ?  360 LEU A N   1 
ATOM 2677 C CA  . LEU A 1 360 ? 93.808  112.281 114.800 1.00 104.09 ?  360 LEU A CA  1 
ATOM 2678 C C   . LEU A 1 360 ? 92.348  112.555 115.116 1.00 106.21 ?  360 LEU A C   1 
ATOM 2679 O O   . LEU A 1 360 ? 91.974  113.695 115.362 1.00 110.92 ?  360 LEU A O   1 
ATOM 2680 C CB  . LEU A 1 360 ? 94.044  112.602 113.325 1.00 99.90  ?  360 LEU A CB  1 
ATOM 2681 C CG  . LEU A 1 360 ? 95.440  112.483 112.706 1.00 105.01 ?  360 LEU A CG  1 
ATOM 2682 C CD1 . LEU A 1 360 ? 95.396  112.896 111.242 1.00 110.78 ?  360 LEU A CD1 1 
ATOM 2683 C CD2 . LEU A 1 360 ? 96.456  113.322 113.459 1.00 107.94 ?  360 LEU A CD2 1 
ATOM 2684 N N   . GLN A 1 361 ? 91.504  111.531 115.190 1.00 109.80 ?  361 GLN A N   1 
ATOM 2685 C CA  . GLN A 1 361 ? 90.056  111.756 115.352 1.00 111.24 ?  361 GLN A CA  1 
ATOM 2686 C C   . GLN A 1 361 ? 89.544  112.128 116.727 1.00 110.17 ?  361 GLN A C   1 
ATOM 2687 O O   . GLN A 1 361 ? 88.569  112.865 116.833 1.00 110.12 ?  361 GLN A O   1 
ATOM 2688 C CB  . GLN A 1 361 ? 89.278  110.515 114.905 1.00 113.90 ?  361 GLN A CB  1 
ATOM 2689 C CG  . GLN A 1 361 ? 89.560  110.032 113.492 1.00 108.10 ?  361 GLN A CG  1 
ATOM 2690 C CD  . GLN A 1 361 ? 88.533  109.029 113.018 1.00 108.33 ?  361 GLN A CD  1 
ATOM 2691 O OE1 . GLN A 1 361 ? 88.729  107.826 113.154 1.00 109.60 ?  361 GLN A OE1 1 
ATOM 2692 N NE2 . GLN A 1 361 ? 87.427  109.517 112.472 1.00 104.07 ?  361 GLN A NE2 1 
ATOM 2693 N N   . GLY A 1 362 ? 90.175  111.639 117.780 1.00 117.13 ?  362 GLY A N   1 
ATOM 2694 C CA  . GLY A 1 362 ? 89.690  111.871 119.135 1.00 118.78 ?  362 GLY A CA  1 
ATOM 2695 C C   . GLY A 1 362 ? 89.672  113.288 119.659 1.00 121.04 ?  362 GLY A C   1 
ATOM 2696 O O   . GLY A 1 362 ? 88.874  113.602 120.536 1.00 123.63 ?  362 GLY A O   1 
ATOM 2697 N N   . PHE A 1 363 ? 90.523  114.154 119.135 1.00 113.01 ?  363 PHE A N   1 
ATOM 2698 C CA  . PHE A 1 363 ? 90.663  115.506 119.677 1.00 114.13 ?  363 PHE A CA  1 
ATOM 2699 C C   . PHE A 1 363 ? 89.419  116.373 119.630 1.00 108.57 ?  363 PHE A C   1 
ATOM 2700 O O   . PHE A 1 363 ? 89.275  117.249 120.469 1.00 106.05 ?  363 PHE A O   1 
ATOM 2701 C CB  . PHE A 1 363 ? 91.848  116.221 119.024 1.00 108.03 ?  363 PHE A CB  1 
ATOM 2702 C CG  . PHE A 1 363 ? 93.138  115.463 119.124 1.00 102.58 ?  363 PHE A CG  1 
ATOM 2703 C CD1 . PHE A 1 363 ? 93.692  115.180 120.356 1.00 103.64 ?  363 PHE A CD1 1 
ATOM 2704 C CD2 . PHE A 1 363 ? 93.785  115.020 117.989 1.00 110.58 ?  363 PHE A CD2 1 
ATOM 2705 C CE1 . PHE A 1 363 ? 94.866  114.471 120.452 1.00 111.65 ?  363 PHE A CE1 1 
ATOM 2706 C CE2 . PHE A 1 363 ? 94.966  114.318 118.077 1.00 112.82 ?  363 PHE A CE2 1 
ATOM 2707 C CZ  . PHE A 1 363 ? 95.508  114.041 119.311 1.00 112.60 ?  363 PHE A CZ  1 
ATOM 2708 N N   . GLY A 1 364 ? 88.524  116.135 118.682 1.00 108.86 ?  364 GLY A N   1 
ATOM 2709 C CA  . GLY A 1 364 ? 87.312  116.934 118.546 1.00 115.46 ?  364 GLY A CA  1 
ATOM 2710 C C   . GLY A 1 364 ? 87.393  118.042 117.530 1.00 118.28 ?  364 GLY A C   1 
ATOM 2711 O O   . GLY A 1 364 ? 86.465  118.843 117.447 1.00 114.63 ?  364 GLY A O   1 
ATOM 2712 N N   . VAL A 1 365 ? 88.483  118.105 116.773 1.00 116.00 ?  365 VAL A N   1 
ATOM 2713 C CA  . VAL A 1 365 ? 88.617  119.078 115.697 1.00 110.37 ?  365 VAL A CA  1 
ATOM 2714 C C   . VAL A 1 365 ? 88.665  118.257 114.414 1.00 111.47 ?  365 VAL A C   1 
ATOM 2715 O O   . VAL A 1 365 ? 88.892  117.051 114.474 1.00 113.59 ?  365 VAL A O   1 
ATOM 2716 C CB  . VAL A 1 365 ? 89.870  119.970 115.848 1.00 107.67 ?  365 VAL A CB  1 
ATOM 2717 C CG1 . VAL A 1 365 ? 89.759  120.834 117.095 1.00 105.59 ?  365 VAL A CG1 1 
ATOM 2718 C CG2 . VAL A 1 365 ? 91.170  119.167 115.875 1.00 108.31 ?  365 VAL A CG2 1 
ATOM 2719 N N   . SER A 1 366 ? 88.427  118.878 113.265 1.00 100.88 ?  366 SER A N   1 
ATOM 2720 C CA  . SER A 1 366 ? 88.500  118.190 111.981 1.00 96.23  ?  366 SER A CA  1 
ATOM 2721 C C   . SER A 1 366 ? 89.796  117.396 111.842 1.00 93.94  ?  366 SER A C   1 
ATOM 2722 O O   . SER A 1 366 ? 90.817  117.844 112.326 1.00 107.00 ?  366 SER A O   1 
ATOM 2723 C CB  . SER A 1 366 ? 88.419  119.224 110.872 1.00 95.84  ?  366 SER A CB  1 
ATOM 2724 O OG  . SER A 1 366 ? 88.581  118.635 109.611 1.00 105.36 ?  366 SER A OG  1 
ATOM 2725 N N   . ILE A 1 367 ? 89.786  116.254 111.148 1.00 77.06  ?  367 ILE A N   1 
ATOM 2726 C CA  . ILE A 1 367 ? 90.982  115.431 111.036 1.00 86.39  ?  367 ILE A CA  1 
ATOM 2727 C C   . ILE A 1 367 ? 91.918  116.083 110.031 1.00 89.09  ?  367 ILE A C   1 
ATOM 2728 O O   . ILE A 1 367 ? 93.058  115.652 109.896 1.00 92.82  ?  367 ILE A O   1 
ATOM 2729 C CB  . ILE A 1 367 ? 90.685  113.958 110.679 1.00 83.36  ?  367 ILE A CB  1 
ATOM 2730 C CG1 . ILE A 1 367 ? 90.080  113.779 109.280 1.00 90.66  ?  367 ILE A CG1 1 
ATOM 2731 C CG2 . ILE A 1 367 ? 89.774  113.352 111.733 1.00 92.47  ?  367 ILE A CG2 1 
ATOM 2732 C CD1 . ILE A 1 367 ? 90.254  112.373 108.746 1.00 86.99  ?  367 ILE A CD1 1 
ATOM 2733 N N   . TYR A 1 368 ? 91.433  117.068 109.271 1.00 91.13  ?  368 TYR A N   1 
ATOM 2734 C CA  . TYR A 1 368 ? 92.250  117.737 108.262 1.00 94.23  ?  368 TYR A CA  1 
ATOM 2735 C C   . TYR A 1 368 ? 92.971  118.894 108.895 1.00 95.24  ?  368 TYR A C   1 
ATOM 2736 O O   . TYR A 1 368 ? 94.154  119.084 108.657 1.00 104.92 ?  368 TYR A O   1 
ATOM 2737 C CB  . TYR A 1 368 ? 91.395  118.197 107.082 1.00 89.00  ?  368 TYR A CB  1 
ATOM 2738 C CG  . TYR A 1 368 ? 90.630  117.072 106.426 1.00 85.64  ?  368 TYR A CG  1 
ATOM 2739 C CD1 . TYR A 1 368 ? 91.266  116.176 105.590 1.00 87.65  ?  368 TYR A CD1 1 
ATOM 2740 C CD2 . TYR A 1 368 ? 89.273  116.902 106.652 1.00 88.86  ?  368 TYR A CD2 1 
ATOM 2741 C CE1 . TYR A 1 368 ? 90.574  115.141 105.003 1.00 91.90  ?  368 TYR A CE1 1 
ATOM 2742 C CE2 . TYR A 1 368 ? 88.575  115.871 106.065 1.00 96.75  ?  368 TYR A CE2 1 
ATOM 2743 C CZ  . TYR A 1 368 ? 89.232  114.994 105.240 1.00 99.25  ?  368 TYR A CZ  1 
ATOM 2744 O OH  . TYR A 1 368 ? 88.546  113.961 104.646 1.00 95.89  ?  368 TYR A OH  1 
ATOM 2745 N N   . LEU A 1 369 ? 92.276  119.663 109.715 1.00 88.31  ?  369 LEU A N   1 
ATOM 2746 C CA  . LEU A 1 369 ? 92.919  120.751 110.427 1.00 88.57  ?  369 LEU A CA  1 
ATOM 2747 C C   . LEU A 1 369 ? 93.988  120.218 111.361 1.00 97.01  ?  369 LEU A C   1 
ATOM 2748 O O   . LEU A 1 369 ? 95.067  120.773 111.422 1.00 102.65 ?  369 LEU A O   1 
ATOM 2749 C CB  . LEU A 1 369 ? 91.890  121.550 111.220 1.00 95.49  ?  369 LEU A CB  1 
ATOM 2750 C CG  . LEU A 1 369 ? 92.362  122.591 112.233 1.00 100.73 ?  369 LEU A CG  1 
ATOM 2751 C CD1 . LEU A 1 369 ? 93.214  123.678 111.591 1.00 98.67  ?  369 LEU A CD1 1 
ATOM 2752 C CD2 . LEU A 1 369 ? 91.170  123.191 112.960 1.00 97.67  ?  369 LEU A CD2 1 
ATOM 2753 N N   . ILE A 1 370 ? 93.707  119.136 112.073 1.00 97.02  ?  370 ILE A N   1 
ATOM 2754 C CA  . ILE A 1 370 ? 94.684  118.548 112.991 1.00 89.73  ?  370 ILE A CA  1 
ATOM 2755 C C   . ILE A 1 370 ? 95.907  118.041 112.240 1.00 91.26  ?  370 ILE A C   1 
ATOM 2756 O O   . ILE A 1 370 ? 96.997  118.166 112.744 1.00 99.69  ?  370 ILE A O   1 
ATOM 2757 C CB  . ILE A 1 370 ? 94.077  117.487 113.939 1.00 80.32  ?  370 ILE A CB  1 
ATOM 2758 C CG1 . ILE A 1 370 ? 95.015  117.144 115.097 1.00 96.59  ?  370 ILE A CG1 1 
ATOM 2759 C CG2 . ILE A 1 370 ? 93.758  116.217 113.200 1.00 91.25  ?  370 ILE A CG2 1 
ATOM 2760 C CD1 . ILE A 1 370 ? 95.170  118.223 116.143 1.00 105.26 ?  370 ILE A CD1 1 
ATOM 2761 N N   . GLN A 1 371 ? 95.752  117.461 111.058 1.00 92.03  ?  371 GLN A N   1 
ATOM 2762 C CA  . GLN A 1 371 ? 96.915  117.053 110.259 1.00 90.49  ?  371 GLN A CA  1 
ATOM 2763 C C   . GLN A 1 371 ? 97.744  118.260 109.859 1.00 88.64  ?  371 GLN A C   1 
ATOM 2764 O O   . GLN A 1 371 ? 98.960  118.197 109.891 1.00 91.44  ?  371 GLN A O   1 
ATOM 2765 C CB  . GLN A 1 371 ? 96.470  116.274 109.018 1.00 89.01  ?  371 GLN A CB  1 
ATOM 2766 C CG  . GLN A 1 371 ? 97.560  115.802 108.059 1.00 91.81  ?  371 GLN A CG  1 
ATOM 2767 C CD  . GLN A 1 371 ? 98.442  114.698 108.607 1.00 104.98 ?  371 GLN A CD  1 
ATOM 2768 O OE1 . GLN A 1 371 ? 98.172  114.120 109.655 1.00 109.34 ?  371 GLN A OE1 1 
ATOM 2769 N NE2 . GLN A 1 371 ? 99.503  114.389 107.878 1.00 101.90 ?  371 GLN A NE2 1 
ATOM 2770 N N   . VAL A 1 372 ? 97.099  119.351 109.464 1.00 86.82  ?  372 VAL A N   1 
ATOM 2771 C CA  . VAL A 1 372 ? 97.815  120.579 109.115 1.00 85.19  ?  372 VAL A CA  1 
ATOM 2772 C C   . VAL A 1 372 ? 98.535  121.163 110.321 1.00 93.02  ?  372 VAL A C   1 
ATOM 2773 O O   . VAL A 1 372 ? 99.672  121.565 110.208 1.00 100.81 ?  372 VAL A O   1 
ATOM 2774 C CB  . VAL A 1 372 ? 96.879  121.649 108.505 1.00 88.27  ?  372 VAL A CB  1 
ATOM 2775 C CG1 . VAL A 1 372 ? 97.550  123.014 108.440 1.00 87.07  ?  372 VAL A CG1 1 
ATOM 2776 C CG2 . VAL A 1 372 ? 96.428  121.227 107.117 1.00 94.70  ?  372 VAL A CG2 1 
ATOM 2777 N N   . ILE A 1 373 ? 97.892  121.192 111.478 1.00 94.61  ?  373 ILE A N   1 
ATOM 2778 C CA  . ILE A 1 373 ? 98.498  121.774 112.674 1.00 84.76  ?  373 ILE A CA  1 
ATOM 2779 C C   . ILE A 1 373 ? 99.711  120.946 113.018 1.00 85.75  ?  373 ILE A C   1 
ATOM 2780 O O   . ILE A 1 373 ? 100.777 121.489 113.222 1.00 94.07  ?  373 ILE A O   1 
ATOM 2781 C CB  . ILE A 1 373 ? 97.533  121.777 113.881 1.00 79.93  ?  373 ILE A CB  1 
ATOM 2782 C CG1 . ILE A 1 373 ? 96.430  122.824 113.708 1.00 87.84  ?  373 ILE A CG1 1 
ATOM 2783 C CG2 . ILE A 1 373 ? 98.288  122.043 115.167 1.00 90.07  ?  373 ILE A CG2 1 
ATOM 2784 C CD1 . ILE A 1 373 ? 95.192  122.539 114.532 1.00 85.65  ?  373 ILE A CD1 1 
ATOM 2785 N N   . PHE A 1 374 ? 99.552  119.636 113.098 1.00 88.88  ?  374 PHE A N   1 
ATOM 2786 C CA  . PHE A 1 374 ? 100.644 118.745 113.437 1.00 87.55  ?  374 PHE A CA  1 
ATOM 2787 C C   . PHE A 1 374 ? 101.826 118.966 112.508 1.00 93.98  ?  374 PHE A C   1 
ATOM 2788 O O   . PHE A 1 374 ? 102.947 119.036 112.975 1.00 98.85  ?  374 PHE A O   1 
ATOM 2789 C CB  . PHE A 1 374 ? 100.236 117.266 113.402 1.00 89.97  ?  374 PHE A CB  1 
ATOM 2790 C CG  . PHE A 1 374 ? 99.646  116.737 114.695 1.00 94.90  ?  374 PHE A CG  1 
ATOM 2791 C CD1 . PHE A 1 374 ? 100.242 116.966 115.919 1.00 95.35  ?  374 PHE A CD1 1 
ATOM 2792 C CD2 . PHE A 1 374 ? 98.522  115.951 114.675 1.00 96.35  ?  374 PHE A CD2 1 
ATOM 2793 C CE1 . PHE A 1 374 ? 99.705  116.455 117.075 1.00 93.37  ?  374 PHE A CE1 1 
ATOM 2794 C CE2 . PHE A 1 374 ? 97.987  115.440 115.846 1.00 92.10  ?  374 PHE A CE2 1 
ATOM 2795 C CZ  . PHE A 1 374 ? 98.577  115.696 117.043 1.00 87.39  ?  374 PHE A CZ  1 
ATOM 2796 N N   . GLY A 1 375 ? 101.598 119.095 111.205 1.00 92.86  ?  375 GLY A N   1 
ATOM 2797 C CA  . GLY A 1 375 ? 102.671 119.337 110.260 1.00 86.54  ?  375 GLY A CA  1 
ATOM 2798 C C   . GLY A 1 375 ? 103.285 120.709 110.393 1.00 90.64  ?  375 GLY A C   1 
ATOM 2799 O O   . GLY A 1 375 ? 104.448 120.874 110.046 1.00 92.58  ?  375 GLY A O   1 
ATOM 2800 N N   . ALA A 1 376 ? 102.524 121.694 110.866 1.00 83.17  ?  376 ALA A N   1 
ATOM 2801 C CA  . ALA A 1 376 ? 103.059 123.031 111.086 1.00 77.81  ?  376 ALA A CA  1 
ATOM 2802 C C   . ALA A 1 376 ? 103.725 123.191 112.417 1.00 90.58  ?  376 ALA A C   1 
ATOM 2803 O O   . ALA A 1 376 ? 104.290 124.238 112.665 1.00 100.30 ?  376 ALA A O   1 
ATOM 2804 C CB  . ALA A 1 376 ? 101.954 124.054 110.962 1.00 80.69  ?  376 ALA A CB  1 
ATOM 2805 N N   . VAL A 1 377 ? 103.720 122.166 113.267 1.00 98.82  ?  377 VAL A N   1 
ATOM 2806 C CA  . VAL A 1 377 ? 104.445 122.226 114.534 1.00 92.29  ?  377 VAL A CA  1 
ATOM 2807 C C   . VAL A 1 377 ? 105.855 121.797 114.293 1.00 95.28  ?  377 VAL A C   1 
ATOM 2808 O O   . VAL A 1 377 ? 106.772 122.300 114.916 1.00 109.09 ?  377 VAL A O   1 
ATOM 2809 C CB  . VAL A 1 377 ? 103.921 121.252 115.579 1.00 88.34  ?  377 VAL A CB  1 
ATOM 2810 C CG1 . VAL A 1 377 ? 104.329 121.702 116.970 1.00 90.59  ?  377 VAL A CG1 1 
ATOM 2811 C CG2 . VAL A 1 377 ? 102.423 121.121 115.481 1.00 91.50  ?  377 VAL A CG2 1 
ATOM 2812 N N   . ASP A 1 378 ? 106.045 120.856 113.386 1.00 101.07 ?  378 ASP A N   1 
ATOM 2813 C CA  . ASP A 1 378 ? 107.371 120.333 113.119 1.00 98.93  ?  378 ASP A CA  1 
ATOM 2814 C C   . ASP A 1 378 ? 108.347 121.421 112.722 1.00 101.65 ?  378 ASP A C   1 
ATOM 2815 O O   . ASP A 1 378 ? 109.543 121.246 112.862 1.00 104.52 ?  378 ASP A O   1 
ATOM 2816 C CB  . ASP A 1 378 ? 107.312 119.281 112.021 1.00 105.96 ?  378 ASP A CB  1 
ATOM 2817 C CG  . ASP A 1 378 ? 106.616 118.023 112.463 1.00 108.13 ?  378 ASP A CG  1 
ATOM 2818 O OD1 . ASP A 1 378 ? 106.148 117.982 113.618 1.00 108.35 ?  378 ASP A OD1 1 
ATOM 2819 O OD2 . ASP A 1 378 ? 106.537 117.074 111.658 1.00 110.14 -1 378 ASP A OD2 1 
ATOM 2820 N N   . LEU A 1 379 ? 107.854 122.544 112.226 1.00 108.05 ?  379 LEU A N   1 
ATOM 2821 C CA  . LEU A 1 379 ? 108.744 123.607 111.765 1.00 110.34 ?  379 LEU A CA  1 
ATOM 2822 C C   . LEU A 1 379 ? 109.306 124.454 112.908 1.00 110.93 ?  379 LEU A C   1 
ATOM 2823 O O   . LEU A 1 379 ? 110.503 124.702 112.948 1.00 117.86 ?  379 LEU A O   1 
ATOM 2824 C CB  . LEU A 1 379 ? 108.039 124.481 110.733 1.00 111.15 ?  379 LEU A CB  1 
ATOM 2825 C CG  . LEU A 1 379 ? 107.328 123.703 109.623 1.00 115.61 ?  379 LEU A CG  1 
ATOM 2826 C CD1 . LEU A 1 379 ? 106.684 124.648 108.621 1.00 110.70 ?  379 LEU A CD1 1 
ATOM 2827 C CD2 . LEU A 1 379 ? 108.286 122.748 108.929 1.00 109.30 ?  379 LEU A CD2 1 
ATOM 2828 N N   . PRO A 1 380 ? 108.458 124.916 113.833 1.00 94.59  ?  380 PRO A N   1 
ATOM 2829 C CA  . PRO A 1 380 ? 109.021 125.633 114.987 1.00 97.29  ?  380 PRO A CA  1 
ATOM 2830 C C   . PRO A 1 380 ? 109.672 124.679 115.961 1.00 98.96  ?  380 PRO A C   1 
ATOM 2831 O O   . PRO A 1 380 ? 110.560 125.111 116.657 1.00 104.85 ?  380 PRO A O   1 
ATOM 2832 C CB  . PRO A 1 380 ? 107.809 126.273 115.643 1.00 93.86  ?  380 PRO A CB  1 
ATOM 2833 C CG  . PRO A 1 380 ? 106.636 125.540 115.132 1.00 95.04  ?  380 PRO A CG  1 
ATOM 2834 C CD  . PRO A 1 380 ? 107.011 125.135 113.748 1.00 91.30  ?  380 PRO A CD  1 
ATOM 2835 N N   . ALA A 1 381 ? 109.259 123.421 115.991 1.00 90.33  ?  381 ALA A N   1 
ATOM 2836 C CA  . ALA A 1 381 ? 109.884 122.436 116.856 1.00 88.79  ?  381 ALA A CA  1 
ATOM 2837 C C   . ALA A 1 381 ? 111.326 122.244 116.472 1.00 88.06  ?  381 ALA A C   1 
ATOM 2838 O O   . ALA A 1 381 ? 112.216 122.388 117.299 1.00 97.69  ?  381 ALA A O   1 
ATOM 2839 C CB  . ALA A 1 381 ? 109.151 121.120 116.767 1.00 93.61  ?  381 ALA A CB  1 
ATOM 2840 N N   . LYS A 1 382 ? 111.569 121.922 115.214 1.00 91.89  ?  382 LYS A N   1 
ATOM 2841 C CA  . LYS A 1 382 ? 112.930 121.669 114.764 1.00 100.24 ?  382 LYS A CA  1 
ATOM 2842 C C   . LYS A 1 382 ? 113.865 122.852 115.001 1.00 103.69 ?  382 LYS A C   1 
ATOM 2843 O O   . LYS A 1 382 ? 115.048 122.652 115.243 1.00 108.43 ?  382 LYS A O   1 
ATOM 2844 C CB  . LYS A 1 382 ? 112.928 121.277 113.291 1.00 101.73 ?  382 LYS A CB  1 
ATOM 2845 C CG  . LYS A 1 382 ? 112.101 120.039 112.996 1.00 108.61 ?  382 LYS A CG  1 
ATOM 2846 C CD  . LYS A 1 382 ? 112.178 119.656 111.529 1.00 108.96 ?  382 LYS A CD  1 
ATOM 2847 C CE  . LYS A 1 382 ? 111.364 118.405 111.250 1.00 106.38 ?  382 LYS A CE  1 
ATOM 2848 N NZ  . LYS A 1 382 ? 111.817 117.264 112.090 1.00 98.04  1  382 LYS A NZ  1 
ATOM 2849 N N   . LEU A 1 383 ? 113.355 124.073 114.988 1.00 106.48 ?  383 LEU A N   1 
ATOM 2850 C CA  . LEU A 1 383 ? 114.199 125.215 115.316 1.00 103.82 ?  383 LEU A CA  1 
ATOM 2851 C C   . LEU A 1 383 ? 114.474 125.231 116.806 1.00 105.14 ?  383 LEU A C   1 
ATOM 2852 O O   . LEU A 1 383 ? 115.623 125.173 117.224 1.00 110.40 ?  383 LEU A O   1 
ATOM 2853 C CB  . LEU A 1 383 ? 113.547 126.522 114.901 1.00 104.94 ?  383 LEU A CB  1 
ATOM 2854 C CG  . LEU A 1 383 ? 114.173 127.780 115.502 1.00 113.78 ?  383 LEU A CG  1 
ATOM 2855 C CD1 . LEU A 1 383 ? 115.607 127.950 115.028 1.00 108.23 ?  383 LEU A CD1 1 
ATOM 2856 C CD2 . LEU A 1 383 ? 113.342 129.006 115.158 1.00 112.19 ?  383 LEU A CD2 1 
ATOM 2857 N N   . VAL A 1 384 ? 113.428 125.302 117.615 1.00 97.30  ?  384 VAL A N   1 
ATOM 2858 C CA  . VAL A 1 384 ? 113.599 125.278 119.061 1.00 97.88  ?  384 VAL A CA  1 
ATOM 2859 C C   . VAL A 1 384 ? 114.537 124.167 119.474 1.00 101.15 ?  384 VAL A C   1 
ATOM 2860 O O   . VAL A 1 384 ? 115.373 124.361 120.345 1.00 106.70 ?  384 VAL A O   1 
ATOM 2861 C CB  . VAL A 1 384 ? 112.267 125.083 119.795 1.00 101.69 ?  384 VAL A CB  1 
ATOM 2862 C CG1 . VAL A 1 384 ? 112.501 124.916 121.287 1.00 98.91  ?  384 VAL A CG1 1 
ATOM 2863 C CG2 . VAL A 1 384 ? 111.338 126.253 119.523 1.00 102.96 ?  384 VAL A CG2 1 
ATOM 2864 N N   . GLY A 1 385 ? 114.411 123.003 118.850 1.00 98.80  ?  385 GLY A N   1 
ATOM 2865 C CA  . GLY A 1 385 ? 115.312 121.911 119.156 1.00 101.75 ?  385 GLY A CA  1 
ATOM 2866 C C   . GLY A 1 385 ? 116.741 122.202 118.762 1.00 104.35 ?  385 GLY A C   1 
ATOM 2867 O O   . GLY A 1 385 ? 117.648 121.903 119.519 1.00 107.88 ?  385 GLY A O   1 
ATOM 2868 N N   . PHE A 1 386 ? 116.951 122.781 117.587 1.00 109.25 ?  386 PHE A N   1 
ATOM 2869 C CA  . PHE A 1 386 ? 118.288 123.149 117.153 1.00 107.68 ?  386 PHE A CA  1 
ATOM 2870 C C   . PHE A 1 386 ? 118.868 124.140 118.129 1.00 106.97 ?  386 PHE A C   1 
ATOM 2871 O O   . PHE A 1 386 ? 120.028 124.051 118.494 1.00 114.59 ?  386 PHE A O   1 
ATOM 2872 C CB  . PHE A 1 386 ? 118.235 123.761 115.758 1.00 109.49 ?  386 PHE A CB  1 
ATOM 2873 C CG  . PHE A 1 386 ? 119.506 124.437 115.333 1.00 115.54 ?  386 PHE A CG  1 
ATOM 2874 C CD1 . PHE A 1 386 ? 120.560 123.698 114.825 1.00 117.51 ?  386 PHE A CD1 1 
ATOM 2875 C CD2 . PHE A 1 386 ? 119.640 125.814 115.420 1.00 114.70 ?  386 PHE A CD2 1 
ATOM 2876 C CE1 . PHE A 1 386 ? 121.729 124.316 114.428 1.00 116.65 ?  386 PHE A CE1 1 
ATOM 2877 C CE2 . PHE A 1 386 ? 120.807 126.437 115.030 1.00 117.05 ?  386 PHE A CE2 1 
ATOM 2878 C CZ  . PHE A 1 386 ? 121.853 125.687 114.531 1.00 115.92 ?  386 PHE A CZ  1 
ATOM 2879 N N   . LEU A 1 387 ? 118.064 125.098 118.547 1.00 101.92 ?  387 LEU A N   1 
ATOM 2880 C CA  . LEU A 1 387 ? 118.548 126.103 119.468 1.00 107.29 ?  387 LEU A CA  1 
ATOM 2881 C C   . LEU A 1 387 ? 118.956 125.506 120.798 1.00 108.28 ?  387 LEU A C   1 
ATOM 2882 O O   . LEU A 1 387 ? 119.988 125.861 121.320 1.00 110.13 ?  387 LEU A O   1 
ATOM 2883 C CB  . LEU A 1 387 ? 117.517 127.207 119.682 1.00 106.53 ?  387 LEU A CB  1 
ATOM 2884 C CG  . LEU A 1 387 ? 117.334 128.172 118.515 1.00 108.30 ?  387 LEU A CG  1 
ATOM 2885 C CD1 . LEU A 1 387 ? 116.253 129.191 118.831 1.00 103.32 ?  387 LEU A CD1 1 
ATOM 2886 C CD2 . LEU A 1 387 ? 118.651 128.858 118.195 1.00 106.11 ?  387 LEU A CD2 1 
ATOM 2887 N N   . VAL A 1 388 ? 118.164 124.584 121.348 1.00 108.22 ?  388 VAL A N   1 
ATOM 2888 C CA  . VAL A 1 388 ? 118.457 123.993 122.657 1.00 108.86 ?  388 VAL A CA  1 
ATOM 2889 C C   . VAL A 1 388 ? 119.596 122.998 122.534 1.00 107.16 ?  388 VAL A C   1 
ATOM 2890 O O   . VAL A 1 388 ? 120.364 122.828 123.457 1.00 109.93 ?  388 VAL A O   1 
ATOM 2891 C CB  . VAL A 1 388 ? 117.217 123.311 123.282 1.00 104.76 ?  388 VAL A CB  1 
ATOM 2892 C CG1 . VAL A 1 388 ? 117.570 122.626 124.594 1.00 104.51 ?  388 VAL A CG1 1 
ATOM 2893 C CG2 . VAL A 1 388 ? 116.115 124.332 123.546 1.00 105.13 ?  388 VAL A CG2 1 
ATOM 2894 N N   . ILE A 1 389 ? 119.668 122.274 121.426 1.00 102.67 ?  389 ILE A N   1 
ATOM 2895 C CA  . ILE A 1 389 ? 120.702 121.273 121.276 1.00 101.90 ?  389 ILE A CA  1 
ATOM 2896 C C   . ILE A 1 389 ? 122.037 121.990 121.359 1.00 105.60 ?  389 ILE A C   1 
ATOM 2897 O O   . ILE A 1 389 ? 122.840 121.704 122.237 1.00 106.58 ?  389 ILE A O   1 
ATOM 2898 C CB  . ILE A 1 389 ? 120.563 120.461 119.973 1.00 104.74 ?  389 ILE A CB  1 
ATOM 2899 C CG1 . ILE A 1 389 ? 119.430 119.436 120.094 1.00 100.74 ?  389 ILE A CG1 1 
ATOM 2900 C CG2 . ILE A 1 389 ? 121.845 119.720 119.677 1.00 106.05 ?  389 ILE A CG2 1 
ATOM 2901 C CD1 . ILE A 1 389 ? 118.871 118.967 118.764 1.00 104.28 ?  389 ILE A CD1 1 
ATOM 2902 N N   . ASN A 1 390 ? 122.271 122.960 120.485 1.00 114.19 ?  390 ASN A N   1 
ATOM 2903 C CA  . ASN A 1 390 ? 123.563 123.630 120.458 1.00 113.82 ?  390 ASN A CA  1 
ATOM 2904 C C   . ASN A 1 390 ? 123.817 124.496 121.697 1.00 112.28 ?  390 ASN A C   1 
ATOM 2905 O O   . ASN A 1 390 ? 124.909 124.470 122.240 1.00 111.53 ?  390 ASN A O   1 
ATOM 2906 C CB  . ASN A 1 390 ? 123.714 124.466 119.190 1.00 117.80 ?  390 ASN A CB  1 
ATOM 2907 C CG  . ASN A 1 390 ? 123.723 123.627 117.923 1.00 118.33 ?  390 ASN A CG  1 
ATOM 2908 O OD1 . ASN A 1 390 ? 123.425 122.436 117.940 1.00 111.22 ?  390 ASN A OD1 1 
ATOM 2909 N ND2 . ASN A 1 390 ? 124.066 124.257 116.810 1.00 119.10 ?  390 ASN A ND2 1 
ATOM 2910 N N   . SER A 1 391 ? 122.848 125.296 122.115 1.00 104.89 ?  391 SER A N   1 
ATOM 2911 C CA  . SER A 1 391 ? 123.060 126.179 123.260 1.00 108.77 ?  391 SER A CA  1 
ATOM 2912 C C   . SER A 1 391 ? 123.241 125.504 124.613 1.00 113.21 ?  391 SER A C   1 
ATOM 2913 O O   . SER A 1 391 ? 124.140 125.890 125.354 1.00 114.88 ?  391 SER A O   1 
ATOM 2914 C CB  . SER A 1 391 ? 121.924 127.195 123.390 1.00 111.59 ?  391 SER A CB  1 
ATOM 2915 O OG  . SER A 1 391 ? 120.754 126.604 123.928 1.00 115.86 ?  391 SER A OG  1 
ATOM 2916 N N   . LEU A 1 392 ? 122.414 124.511 124.941 1.00 114.07 ?  392 LEU A N   1 
ATOM 2917 C CA  . LEU A 1 392 ? 122.459 123.869 126.274 1.00 111.91 ?  392 LEU A CA  1 
ATOM 2918 C C   . LEU A 1 392 ? 123.215 122.554 126.331 1.00 112.33 ?  392 LEU A C   1 
ATOM 2919 O O   . LEU A 1 392 ? 124.037 122.355 127.221 1.00 110.19 ?  392 LEU A O   1 
ATOM 2920 C CB  . LEU A 1 392 ? 121.039 123.672 126.812 1.00 107.51 ?  392 LEU A CB  1 
ATOM 2921 C CG  . LEU A 1 392 ? 120.433 124.950 127.396 1.00 108.77 ?  392 LEU A CG  1 
ATOM 2922 C CD1 . LEU A 1 392 ? 118.947 125.068 127.103 1.00 109.40 ?  392 LEU A CD1 1 
ATOM 2923 C CD2 . LEU A 1 392 ? 120.710 125.040 128.889 1.00 110.37 ?  392 LEU A CD2 1 
ATOM 2924 N N   . GLY A 1 393 ? 122.951 121.661 125.392 1.00 107.10 ?  393 GLY A N   1 
ATOM 2925 C CA  . GLY A 1 393 ? 123.647 120.399 125.342 1.00 102.10 ?  393 GLY A CA  1 
ATOM 2926 C C   . GLY A 1 393 ? 122.830 119.475 124.496 1.00 107.10 ?  393 GLY A C   1 
ATOM 2927 O O   . GLY A 1 393 ? 121.688 119.782 124.207 1.00 116.38 ?  393 GLY A O   1 
ATOM 2928 N N   . ARG A 1 394 ? 123.376 118.328 124.148 1.00 109.67 ?  394 ARG A N   1 
ATOM 2929 C CA  . ARG A 1 394 ? 122.695 117.395 123.261 1.00 107.66 ?  394 ARG A CA  1 
ATOM 2930 C C   . ARG A 1 394 ? 121.906 116.438 124.119 1.00 109.86 ?  394 ARG A C   1 
ATOM 2931 O O   . ARG A 1 394 ? 120.909 115.898 123.662 1.00 112.89 ?  394 ARG A O   1 
ATOM 2932 C CB  . ARG A 1 394 ? 123.726 116.646 122.424 1.00 108.69 ?  394 ARG A CB  1 
ATOM 2933 C CG  . ARG A 1 394 ? 124.805 117.547 121.808 1.00 111.46 ?  394 ARG A CG  1 
ATOM 2934 C CD  . ARG A 1 394 ? 124.620 117.704 120.323 1.00 115.16 ?  394 ARG A CD  1 
ATOM 2935 N NE  . ARG A 1 394 ? 125.253 118.901 119.765 1.00 116.12 ?  394 ARG A NE  1 
ATOM 2936 C CZ  . ARG A 1 394 ? 126.557 119.052 119.517 1.00 116.75 ?  394 ARG A CZ  1 
ATOM 2937 N NH1 . ARG A 1 394 ? 126.983 120.192 118.972 1.00 116.16 1  394 ARG A NH1 1 
ATOM 2938 N NH2 . ARG A 1 394 ? 127.449 118.111 119.832 1.00 115.44 ?  394 ARG A NH2 1 
ATOM 2939 N N   . ARG A 1 395 ? 122.349 116.212 125.354 1.00 106.36 ?  395 ARG A N   1 
ATOM 2940 C CA  . ARG A 1 395 ? 121.647 115.346 126.301 1.00 105.68 ?  395 ARG A CA  1 
ATOM 2941 C C   . ARG A 1 395 ? 120.538 116.083 127.053 1.00 108.00 ?  395 ARG A C   1 
ATOM 2942 O O   . ARG A 1 395 ? 119.468 115.518 127.215 1.00 109.87 ?  395 ARG A O   1 
ATOM 2943 C CB  . ARG A 1 395 ? 122.647 114.697 127.261 1.00 103.33 ?  395 ARG A CB  1 
ATOM 2944 C CG  . ARG A 1 395 ? 122.086 113.651 128.198 1.00 101.01 ?  395 ARG A CG  1 
ATOM 2945 C CD  . ARG A 1 395 ? 123.167 113.181 129.152 1.00 104.47 ?  395 ARG A CD  1 
ATOM 2946 N NE  . ARG A 1 395 ? 123.692 114.246 130.004 1.00 110.60 ?  395 ARG A NE  1 
ATOM 2947 C CZ  . ARG A 1 395 ? 124.706 114.113 130.862 1.00 112.23 ?  395 ARG A CZ  1 
ATOM 2948 N NH1 . ARG A 1 395 ? 125.339 112.947 131.025 1.00 104.82 1  395 ARG A NH1 1 
ATOM 2949 N NH2 . ARG A 1 395 ? 125.093 115.168 131.578 1.00 115.65 ?  395 ARG A NH2 1 
ATOM 2950 N N   . PRO A 1 396 ? 120.778 117.329 127.544 1.00 106.27 ?  396 PRO A N   1 
ATOM 2951 C CA  . PRO A 1 396 ? 119.646 118.021 128.161 1.00 98.27  ?  396 PRO A CA  1 
ATOM 2952 C C   . PRO A 1 396 ? 118.478 118.156 127.205 1.00 95.56  ?  396 PRO A C   1 
ATOM 2953 O O   . PRO A 1 396 ? 117.348 118.064 127.650 1.00 102.93 ?  396 PRO A O   1 
ATOM 2954 C CB  . PRO A 1 396 ? 120.225 119.372 128.511 1.00 95.44  ?  396 PRO A CB  1 
ATOM 2955 C CG  . PRO A 1 396 ? 121.634 119.070 128.846 1.00 103.72 ?  396 PRO A CG  1 
ATOM 2956 C CD  . PRO A 1 396 ? 122.038 118.038 127.837 1.00 107.20 ?  396 PRO A CD  1 
ATOM 2957 N N   . ALA A 1 397 ? 118.726 118.384 125.928 1.00 85.72  ?  397 ALA A N   1 
ATOM 2958 C CA  . ALA A 1 397 ? 117.653 118.441 124.950 1.00 85.71  ?  397 ALA A CA  1 
ATOM 2959 C C   . ALA A 1 397 ? 116.885 117.142 124.803 1.00 90.02  ?  397 ALA A C   1 
ATOM 2960 O O   . ALA A 1 397 ? 115.683 117.172 124.626 1.00 102.35 ?  397 ALA A O   1 
ATOM 2961 C CB  . ALA A 1 397 ? 118.189 118.856 123.606 1.00 97.35  ?  397 ALA A CB  1 
ATOM 2962 N N   . GLN A 1 398 ? 117.545 115.989 124.911 1.00 93.97  ?  398 GLN A N   1 
ATOM 2963 C CA  . GLN A 1 398 ? 116.869 114.686 124.805 1.00 93.35  ?  398 GLN A CA  1 
ATOM 2964 C C   . GLN A 1 398 ? 116.040 114.348 126.041 1.00 97.03  ?  398 GLN A C   1 
ATOM 2965 O O   . GLN A 1 398 ? 114.996 113.734 125.913 1.00 101.53 ?  398 GLN A O   1 
ATOM 2966 C CB  . GLN A 1 398 ? 117.886 113.577 124.545 1.00 93.13  ?  398 GLN A CB  1 
ATOM 2967 C CG  . GLN A 1 398 ? 117.315 112.256 124.061 1.00 92.40  ?  398 GLN A CG  1 
ATOM 2968 C CD  . GLN A 1 398 ? 116.715 112.338 122.677 1.00 94.96  ?  398 GLN A CD  1 
ATOM 2969 O OE1 . GLN A 1 398 ? 115.508 112.206 122.512 1.00 96.05  ?  398 GLN A OE1 1 
ATOM 2970 N NE2 . GLN A 1 398 ? 117.550 112.559 121.676 1.00 96.06  ?  398 GLN A NE2 1 
ATOM 2971 N N   . MET A 1 399 ? 116.492 114.718 127.233 1.00 96.59  ?  399 MET A N   1 
ATOM 2972 C CA  . MET A 1 399 ? 115.688 114.511 128.437 1.00 90.14  ?  399 MET A CA  1 
ATOM 2973 C C   . MET A 1 399 ? 114.454 115.367 128.317 1.00 99.67  ?  399 MET A C   1 
ATOM 2974 O O   . MET A 1 399 ? 113.391 114.915 128.652 1.00 102.83 ?  399 MET A O   1 
ATOM 2975 C CB  . MET A 1 399 ? 116.410 114.993 129.697 1.00 88.49  ?  399 MET A CB  1 
ATOM 2976 C CG  . MET A 1 399 ? 117.609 114.198 130.152 1.00 101.09 ?  399 MET A CG  1 
ATOM 2977 S SD  . MET A 1 399 ? 118.496 114.985 131.505 1.00 126.78 ?  399 MET A SD  1 
ATOM 2978 C CE  . MET A 1 399 ? 120.081 114.160 131.419 1.00 94.75  ?  399 MET A CE  1 
ATOM 2979 N N   . ALA A 1 400 ? 114.595 116.613 127.885 1.00 89.80  ?  400 ALA A N   1 
ATOM 2980 C CA  . ALA A 1 400 ? 113.496 117.561 127.791 1.00 79.31  ?  400 ALA A CA  1 
ATOM 2981 C C   . ALA A 1 400 ? 112.518 117.261 126.688 1.00 78.69  ?  400 ALA A C   1 
ATOM 2982 O O   . ALA A 1 400 ? 111.330 117.389 126.874 1.00 95.10  ?  400 ALA A O   1 
ATOM 2983 C CB  . ALA A 1 400 ? 114.017 118.966 127.641 1.00 79.42  ?  400 ALA A CB  1 
ATOM 2984 N N   . ALA A 1 401 ? 113.007 116.882 125.528 1.00 67.17  ?  401 ALA A N   1 
ATOM 2985 C CA  . ALA A 1 401 ? 112.132 116.533 124.433 1.00 70.27  ?  401 ALA A CA  1 
ATOM 2986 C C   . ALA A 1 401 ? 111.308 115.303 124.711 1.00 84.48  ?  401 ALA A C   1 
ATOM 2987 O O   . ALA A 1 401 ? 110.153 115.245 124.330 1.00 95.88  ?  401 ALA A O   1 
ATOM 2988 C CB  . ALA A 1 401 ? 112.922 116.366 123.165 1.00 68.03  ?  401 ALA A CB  1 
ATOM 2989 N N   . LEU A 1 402 ? 111.871 114.323 125.404 1.00 86.67  ?  402 LEU A N   1 
ATOM 2990 C CA  . LEU A 1 402 ? 111.148 113.090 125.680 1.00 80.31  ?  402 LEU A CA  1 
ATOM 2991 C C   . LEU A 1 402 ? 110.284 113.163 126.932 1.00 84.77  ?  402 LEU A C   1 
ATOM 2992 O O   . LEU A 1 402 ? 109.164 112.679 126.929 1.00 85.73  ?  402 LEU A O   1 
ATOM 2993 C CB  . LEU A 1 402 ? 112.097 111.903 125.732 1.00 88.20  ?  402 LEU A CB  1 
ATOM 2994 C CG  . LEU A 1 402 ? 112.541 111.334 124.391 1.00 90.04  ?  402 LEU A CG  1 
ATOM 2995 C CD1 . LEU A 1 402 ? 113.710 110.388 124.579 1.00 93.73  ?  402 LEU A CD1 1 
ATOM 2996 C CD2 . LEU A 1 402 ? 111.376 110.627 123.724 1.00 89.57  ?  402 LEU A CD2 1 
ATOM 2997 N N   . LEU A 1 403 ? 110.776 113.788 127.991 1.00 76.31  ?  403 LEU A N   1 
ATOM 2998 C CA  . LEU A 1 403 ? 109.994 113.925 129.209 1.00 77.89  ?  403 LEU A CA  1 
ATOM 2999 C C   . LEU A 1 403 ? 108.779 114.793 128.982 1.00 84.32  ?  403 LEU A C   1 
ATOM 3000 O O   . LEU A 1 403 ? 107.687 114.431 129.382 1.00 95.59  ?  403 LEU A O   1 
ATOM 3001 C CB  . LEU A 1 403 ? 110.821 114.501 130.347 1.00 81.53  ?  403 LEU A CB  1 
ATOM 3002 C CG  . LEU A 1 403 ? 110.178 114.551 131.727 1.00 85.94  ?  403 LEU A CG  1 
ATOM 3003 C CD1 . LEU A 1 403 ? 109.815 113.150 132.182 1.00 91.30  ?  403 LEU A CD1 1 
ATOM 3004 C CD2 . LEU A 1 403 ? 111.126 115.203 132.716 1.00 86.11  ?  403 LEU A CD2 1 
ATOM 3005 N N   . LEU A 1 404 ? 108.954 115.938 128.339 1.00 90.57  ?  404 LEU A N   1 
ATOM 3006 C CA  . LEU A 1 404 ? 107.828 116.818 128.060 1.00 85.97  ?  404 LEU A CA  1 
ATOM 3007 C C   . LEU A 1 404 ? 106.810 116.147 127.160 1.00 93.93  ?  404 LEU A C   1 
ATOM 3008 O O   . LEU A 1 404 ? 105.621 116.278 127.385 1.00 103.30 ?  404 LEU A O   1 
ATOM 3009 C CB  . LEU A 1 404 ? 108.271 118.147 127.467 1.00 86.52  ?  404 LEU A CB  1 
ATOM 3010 C CG  . LEU A 1 404 ? 107.212 119.238 127.322 1.00 92.95  ?  404 LEU A CG  1 
ATOM 3011 C CD1 . LEU A 1 404 ? 106.551 119.523 128.661 1.00 93.99  ?  404 LEU A CD1 1 
ATOM 3012 C CD2 . LEU A 1 404 ? 107.833 120.502 126.755 1.00 94.10  ?  404 LEU A CD2 1 
ATOM 3013 N N   . ALA A 1 405 ? 107.250 115.405 126.157 1.00 89.63  ?  405 ALA A N   1 
ATOM 3014 C CA  . ALA A 1 405 ? 106.305 114.679 125.324 1.00 92.57  ?  405 ALA A CA  1 
ATOM 3015 C C   . ALA A 1 405 ? 105.548 113.663 126.140 1.00 93.23  ?  405 ALA A C   1 
ATOM 3016 O O   . ALA A 1 405 ? 104.347 113.537 125.994 1.00 95.37  ?  405 ALA A O   1 
ATOM 3017 C CB  . ALA A 1 405 ? 107.020 113.987 124.192 1.00 93.52  ?  405 ALA A CB  1 
ATOM 3018 N N   . GLY A 1 406 ? 106.235 112.946 127.016 1.00 84.14  ?  406 GLY A N   1 
ATOM 3019 C CA  . GLY A 1 406 ? 105.574 111.986 127.870 1.00 81.30  ?  406 GLY A CA  1 
ATOM 3020 C C   . GLY A 1 406 ? 104.591 112.624 128.815 1.00 84.11  ?  406 GLY A C   1 
ATOM 3021 O O   . GLY A 1 406 ? 103.516 112.093 129.021 1.00 93.62  ?  406 GLY A O   1 
ATOM 3022 N N   . ILE A 1 407 ? 104.937 113.762 129.408 1.00 85.87  ?  407 ILE A N   1 
ATOM 3023 C CA  . ILE A 1 407 ? 104.018 114.468 130.296 1.00 89.44  ?  407 ILE A CA  1 
ATOM 3024 C C   . ILE A 1 407 ? 102.797 114.935 129.518 1.00 95.46  ?  407 ILE A C   1 
ATOM 3025 O O   . ILE A 1 407 ? 101.690 114.826 130.009 1.00 95.41  ?  407 ILE A O   1 
ATOM 3026 C CB  . ILE A 1 407 ? 104.687 115.667 131.000 1.00 86.84  ?  407 ILE A CB  1 
ATOM 3027 C CG1 . ILE A 1 407 ? 105.700 115.174 132.041 1.00 91.61  ?  407 ILE A CG1 1 
ATOM 3028 C CG2 . ILE A 1 407 ? 103.649 116.564 131.671 1.00 87.99  ?  407 ILE A CG2 1 
ATOM 3029 C CD1 . ILE A 1 407 ? 106.804 116.163 132.340 1.00 95.55  ?  407 ILE A CD1 1 
ATOM 3030 N N   . CYS A 1 408 ? 102.987 115.462 128.318 1.00 95.68  ?  408 CYS A N   1 
ATOM 3031 C CA  . CYS A 1 408 ? 101.868 115.885 127.484 1.00 90.76  ?  408 CYS A CA  1 
ATOM 3032 C C   . CYS A 1 408 ? 100.935 114.757 127.051 1.00 95.61  ?  408 CYS A C   1 
ATOM 3033 O O   . CYS A 1 408 ? 99.732  114.940 127.047 1.00 101.91 ?  408 CYS A O   1 
ATOM 3034 C CB  . CYS A 1 408 ? 102.385 116.589 126.245 1.00 89.98  ?  408 CYS A CB  1 
ATOM 3035 S SG  . CYS A 1 408 ? 103.139 118.193 126.551 1.00 120.11 ?  408 CYS A SG  1 
ATOM 3036 N N   . ILE A 1 409 ? 101.478 113.604 126.683 1.00 97.83  ?  409 ILE A N   1 
ATOM 3037 C CA  . ILE A 1 409 ? 100.666 112.465 126.235 1.00 98.75  ?  409 ILE A CA  1 
ATOM 3038 C C   . ILE A 1 409 ? 99.908  111.877 127.416 1.00 94.37  ?  409 ILE A C   1 
ATOM 3039 O O   . ILE A 1 409 ? 98.745  111.531 127.277 1.00 92.98  ?  409 ILE A O   1 
ATOM 3040 C CB  . ILE A 1 409 ? 101.535 111.384 125.557 1.00 99.53  ?  409 ILE A CB  1 
ATOM 3041 C CG1 . ILE A 1 409 ? 102.096 111.911 124.233 1.00 95.28  ?  409 ILE A CG1 1 
ATOM 3042 C CG2 . ILE A 1 409 ? 100.739 110.111 125.309 1.00 97.86  ?  409 ILE A CG2 1 
ATOM 3043 C CD1 . ILE A 1 409 ? 103.340 111.201 123.749 1.00 89.62  ?  409 ILE A CD1 1 
ATOM 3044 N N   . LEU A 1 410 ? 100.544 111.766 128.570 1.00 88.74  ?  410 LEU A N   1 
ATOM 3045 C CA  . LEU A 1 410 ? 99.860  111.266 129.754 1.00 88.23  ?  410 LEU A CA  1 
ATOM 3046 C C   . LEU A 1 410 ? 98.793  112.238 130.250 1.00 94.01  ?  410 LEU A C   1 
ATOM 3047 O O   . LEU A 1 410 ? 97.832  111.821 130.882 1.00 95.28  ?  410 LEU A O   1 
ATOM 3048 C CB  . LEU A 1 410 ? 100.860 110.978 130.867 1.00 85.83  ?  410 LEU A CB  1 
ATOM 3049 C CG  . LEU A 1 410 ? 101.896 109.895 130.602 1.00 86.23  ?  410 LEU A CG  1 
ATOM 3050 C CD1 . LEU A 1 410 ? 102.913 109.861 131.729 1.00 89.07  ?  410 LEU A CD1 1 
ATOM 3051 C CD2 . LEU A 1 410 ? 101.205 108.553 130.461 1.00 90.39  ?  410 LEU A CD2 1 
ATOM 3052 N N   . LEU A 1 411 ? 98.952  113.527 129.970 1.00 92.48  ?  411 LEU A N   1 
ATOM 3053 C CA  . LEU A 1 411 ? 97.949  114.513 130.365 1.00 91.60  ?  411 LEU A CA  1 
ATOM 3054 C C   . LEU A 1 411 ? 96.853  114.601 129.329 1.00 99.43  ?  411 LEU A C   1 
ATOM 3055 O O   . LEU A 1 411 ? 95.806  115.186 129.583 1.00 107.63 ?  411 LEU A O   1 
ATOM 3056 C CB  . LEU A 1 411 ? 98.581  115.881 130.570 1.00 95.09  ?  411 LEU A CB  1 
ATOM 3057 C CG  . LEU A 1 411 ? 99.345  116.097 131.871 1.00 101.40 ?  411 LEU A CG  1 
ATOM 3058 C CD1 . LEU A 1 411 ? 99.970  117.481 131.881 1.00 103.44 ?  411 LEU A CD1 1 
ATOM 3059 C CD2 . LEU A 1 411 ? 98.410  115.920 133.055 1.00 95.99  ?  411 LEU A CD2 1 
ATOM 3060 N N   . ASN A 1 412 ? 97.083  114.046 128.149 1.00 100.47 ?  412 ASN A N   1 
ATOM 3061 C CA  . ASN A 1 412 ? 96.046  114.004 127.137 1.00 99.93  ?  412 ASN A CA  1 
ATOM 3062 C C   . ASN A 1 412 ? 95.170  112.871 127.584 1.00 107.02 ?  412 ASN A C   1 
ATOM 3063 O O   . ASN A 1 412 ? 93.954  112.923 127.437 1.00 105.14 ?  412 ASN A O   1 
ATOM 3064 C CB  . ASN A 1 412 ? 96.643  113.721 125.772 1.00 93.07  ?  412 ASN A CB  1 
ATOM 3065 C CG  . ASN A 1 412 ? 95.668  113.948 124.649 1.00 101.93 ?  412 ASN A CG  1 
ATOM 3066 O OD1 . ASN A 1 412 ? 94.789  114.801 124.741 1.00 110.83 ?  412 ASN A OD1 1 
ATOM 3067 N ND2 . ASN A 1 412 ? 95.815  113.185 123.582 1.00 106.07 ?  412 ASN A ND2 1 
ATOM 3068 N N   . GLY A 1 413 ? 95.783  111.831 128.138 1.00 107.15 ?  413 GLY A N   1 
ATOM 3069 C CA  . GLY A 1 413 ? 95.015  110.719 128.680 1.00 103.04 ?  413 GLY A CA  1 
ATOM 3070 C C   . GLY A 1 413 ? 94.154  111.041 129.878 1.00 100.62 ?  413 GLY A C   1 
ATOM 3071 O O   . GLY A 1 413 ? 93.051  110.523 129.992 1.00 107.00 ?  413 GLY A O   1 
ATOM 3072 N N   . VAL A 1 414 ? 94.654  111.872 130.780 1.00 101.04 ?  414 VAL A N   1 
ATOM 3073 C CA  . VAL A 1 414 ? 93.918  112.234 131.993 1.00 98.92  ?  414 VAL A CA  1 
ATOM 3074 C C   . VAL A 1 414 ? 92.844  113.301 131.742 1.00 102.14 ?  414 VAL A C   1 
ATOM 3075 O O   . VAL A 1 414 ? 91.729  113.152 132.232 1.00 98.87  ?  414 VAL A O   1 
ATOM 3076 C CB  . VAL A 1 414 ? 94.885  112.723 133.098 1.00 101.66 ?  414 VAL A CB  1 
ATOM 3077 C CG1 . VAL A 1 414 ? 94.130  113.298 134.291 1.00 102.31 ?  414 VAL A CG1 1 
ATOM 3078 C CG2 . VAL A 1 414 ? 95.798  111.589 133.553 1.00 100.22 ?  414 VAL A CG2 1 
ATOM 3079 N N   . ILE A 1 415 ? 93.151  114.364 130.989 1.00 111.52 ?  415 ILE A N   1 
ATOM 3080 C CA  . ILE A 1 415 ? 92.191  115.448 130.792 1.00 111.35 ?  415 ILE A CA  1 
ATOM 3081 C C   . ILE A 1 415 ? 90.945  114.944 130.077 1.00 114.23 ?  415 ILE A C   1 
ATOM 3082 O O   . ILE A 1 415 ? 91.044  114.170 129.129 1.00 110.51 ?  415 ILE A O   1 
ATOM 3083 C CB  . ILE A 1 415 ? 92.881  116.620 130.062 1.00 110.54 ?  415 ILE A CB  1 
ATOM 3084 C CG1 . ILE A 1 415 ? 93.880  117.273 131.012 1.00 109.71 ?  415 ILE A CG1 1 
ATOM 3085 C CG2 . ILE A 1 415 ? 91.889  117.660 129.569 1.00 115.14 ?  415 ILE A CG2 1 
ATOM 3086 C CD1 . ILE A 1 415 ? 94.792  118.270 130.351 1.00 111.75 ?  415 ILE A CD1 1 
ATOM 3087 N N   . PRO A 1 416 ? 89.734  115.395 130.503 1.00 123.18 ?  416 PRO A N   1 
ATOM 3088 C CA  . PRO A 1 416 ? 88.551  114.801 129.862 1.00 122.59 ?  416 PRO A CA  1 
ATOM 3089 C C   . PRO A 1 416 ? 88.408  115.132 128.391 1.00 121.94 ?  416 PRO A C   1 
ATOM 3090 O O   . PRO A 1 416 ? 88.942  116.140 127.952 1.00 128.25 ?  416 PRO A O   1 
ATOM 3091 C CB  . PRO A 1 416 ? 87.382  115.424 130.629 1.00 123.08 ?  416 PRO A CB  1 
ATOM 3092 C CG  . PRO A 1 416 ? 87.970  116.023 131.853 1.00 123.41 ?  416 PRO A CG  1 
ATOM 3093 C CD  . PRO A 1 416 ? 89.322  116.471 131.425 1.00 118.39 ?  416 PRO A CD  1 
ATOM 3094 N N   . GLN A 1 417 ? 87.687  114.309 127.640 1.00 125.93 ?  417 GLN A N   1 
ATOM 3095 C CA  . GLN A 1 417 ? 87.551  114.528 126.202 1.00 125.55 ?  417 GLN A CA  1 
ATOM 3096 C C   . GLN A 1 417 ? 86.721  115.756 125.889 1.00 126.79 ?  417 GLN A C   1 
ATOM 3097 O O   . GLN A 1 417 ? 86.751  116.258 124.770 1.00 128.86 ?  417 GLN A O   1 
ATOM 3098 C CB  . GLN A 1 417 ? 86.926  113.308 125.535 1.00 126.94 ?  417 GLN A CB  1 
ATOM 3099 C CG  . GLN A 1 417 ? 87.833  112.093 125.495 1.00 127.98 ?  417 GLN A CG  1 
ATOM 3100 C CD  . GLN A 1 417 ? 89.021  112.286 124.575 1.00 130.31 ?  417 GLN A CD  1 
ATOM 3101 O OE1 . GLN A 1 417 ? 89.142  113.309 123.901 1.00 127.00 ?  417 GLN A OE1 1 
ATOM 3102 N NE2 . GLN A 1 417 ? 89.905  111.296 124.537 1.00 127.76 ?  417 GLN A NE2 1 
ATOM 3103 N N   . ASP A 1 418 ? 85.980  116.246 126.872 1.00 129.80 ?  418 ASP A N   1 
ATOM 3104 C CA  . ASP A 1 418 ? 85.179  117.440 126.669 1.00 131.27 ?  418 ASP A CA  1 
ATOM 3105 C C   . ASP A 1 418 ? 86.089  118.583 126.286 1.00 131.66 ?  418 ASP A C   1 
ATOM 3106 O O   . ASP A 1 418 ? 85.749  119.395 125.430 1.00 128.24 ?  418 ASP A O   1 
ATOM 3107 C CB  . ASP A 1 418 ? 84.412  117.787 127.939 1.00 131.18 ?  418 ASP A CB  1 
ATOM 3108 C CG  . ASP A 1 418 ? 83.596  116.625 128.462 1.00 134.69 ?  418 ASP A CG  1 
ATOM 3109 O OD1 . ASP A 1 418 ? 83.612  115.550 127.827 1.00 133.27 ?  418 ASP A OD1 1 
ATOM 3110 O OD2 . ASP A 1 418 ? 82.938  116.788 129.510 1.00 134.93 -1 418 ASP A OD2 1 
ATOM 3111 N N   . GLN A 1 419 ? 87.252  118.654 126.923 1.00 121.50 ?  419 GLN A N   1 
ATOM 3112 C CA  . GLN A 1 419 ? 88.212  119.693 126.606 1.00 118.19 ?  419 GLN A CA  1 
ATOM 3113 C C   . GLN A 1 419 ? 88.908  119.364 125.303 1.00 119.57 ?  419 GLN A C   1 
ATOM 3114 O O   . GLN A 1 419 ? 89.714  118.443 125.245 1.00 116.27 ?  419 GLN A O   1 
ATOM 3115 C CB  . GLN A 1 419 ? 89.230  119.808 127.727 1.00 113.71 ?  419 GLN A CB  1 
ATOM 3116 C CG  . GLN A 1 419 ? 88.633  120.220 129.059 1.00 118.61 ?  419 GLN A CG  1 
ATOM 3117 C CD  . GLN A 1 419 ? 88.148  121.654 129.052 1.00 122.44 ?  419 GLN A CD  1 
ATOM 3118 O OE1 . GLN A 1 419 ? 88.501  122.435 128.171 1.00 119.38 ?  419 GLN A OE1 1 
ATOM 3119 N NE2 . GLN A 1 419 ? 87.340  122.009 130.041 1.00 121.95 ?  419 GLN A NE2 1 
ATOM 3120 N N   . SER A 1 420 ? 88.594  120.110 124.252 1.00 117.38 ?  420 SER A N   1 
ATOM 3121 C CA  . SER A 1 420 ? 89.245  119.874 122.970 1.00 115.30 ?  420 SER A CA  1 
ATOM 3122 C C   . SER A 1 420 ? 90.481  120.729 122.787 1.00 112.85 ?  420 SER A C   1 
ATOM 3123 O O   . SER A 1 420 ? 91.469  120.271 122.227 1.00 109.43 ?  420 SER A O   1 
ATOM 3124 C CB  . SER A 1 420 ? 88.281  120.151 121.825 1.00 114.99 ?  420 SER A CB  1 
ATOM 3125 O OG  . SER A 1 420 ? 88.944  120.047 120.579 1.00 113.31 ?  420 SER A OG  1 
ATOM 3126 N N   . ILE A 1 421 ? 90.427  121.976 123.237 1.00 111.93 ?  421 ILE A N   1 
ATOM 3127 C CA  . ILE A 1 421 ? 91.573  122.869 123.118 1.00 111.83 ?  421 ILE A CA  1 
ATOM 3128 C C   . ILE A 1 421 ? 92.715  122.451 124.041 1.00 113.91 ?  421 ILE A C   1 
ATOM 3129 O O   . ILE A 1 421 ? 93.876  122.506 123.650 1.00 112.95 ?  421 ILE A O   1 
ATOM 3130 C CB  . ILE A 1 421 ? 91.179  124.315 123.420 1.00 111.84 ?  421 ILE A CB  1 
ATOM 3131 C CG1 . ILE A 1 421 ? 89.959  124.711 122.594 1.00 115.30 ?  421 ILE A CG1 1 
ATOM 3132 C CG2 . ILE A 1 421 ? 92.342  125.250 123.135 1.00 107.66 ?  421 ILE A CG2 1 
ATOM 3133 C CD1 . ILE A 1 421 ? 89.475  126.118 122.866 1.00 111.92 ?  421 ILE A CD1 1 
ATOM 3134 N N   . VAL A 1 422 ? 92.395  122.029 125.259 1.00 110.43 ?  422 VAL A N   1 
ATOM 3135 C CA  . VAL A 1 422 ? 93.421  121.579 126.186 1.00 104.17 ?  422 VAL A CA  1 
ATOM 3136 C C   . VAL A 1 422 ? 94.001  120.269 125.706 1.00 107.82 ?  422 VAL A C   1 
ATOM 3137 O O   . VAL A 1 422 ? 95.201  120.057 125.799 1.00 115.58 ?  422 VAL A O   1 
ATOM 3138 C CB  . VAL A 1 422 ? 92.871  121.400 127.599 1.00 107.45 ?  422 VAL A CB  1 
ATOM 3139 C CG1 . VAL A 1 422 ? 94.009  121.180 128.580 1.00 108.46 ?  422 VAL A CG1 1 
ATOM 3140 C CG2 . VAL A 1 422 ? 92.051  122.613 128.000 1.00 110.10 ?  422 VAL A CG2 1 
ATOM 3141 N N   . ARG A 1 423 ? 93.164  119.377 125.199 1.00 106.54 ?  423 ARG A N   1 
ATOM 3142 C CA  . ARG A 1 423 ? 93.674  118.130 124.626 1.00 103.39 ?  423 ARG A CA  1 
ATOM 3143 C C   . ARG A 1 423 ? 94.374  118.273 123.284 1.00 103.95 ?  423 ARG A C   1 
ATOM 3144 O O   . ARG A 1 423 ? 95.345  117.584 123.031 1.00 108.85 ?  423 ARG A O   1 
ATOM 3145 C CB  . ARG A 1 423 ? 92.584  117.067 124.524 1.00 102.56 ?  423 ARG A CB  1 
ATOM 3146 C CG  . ARG A 1 423 ? 92.161  116.486 125.865 1.00 107.78 ?  423 ARG A CG  1 
ATOM 3147 C CD  . ARG A 1 423 ? 91.250  115.280 125.715 1.00 103.62 ?  423 ARG A CD  1 
ATOM 3148 N NE  . ARG A 1 423 ? 91.985  114.041 125.451 1.00 110.53 ?  423 ARG A NE  1 
ATOM 3149 C CZ  . ARG A 1 423 ? 92.209  113.477 124.256 1.00 112.66 ?  423 ARG A CZ  1 
ATOM 3150 N NH1 . ARG A 1 423 ? 91.757  114.010 123.116 1.00 113.11 1  423 ARG A NH1 1 
ATOM 3151 N NH2 . ARG A 1 423 ? 92.902  112.339 124.202 1.00 109.17 ?  423 ARG A NH2 1 
ATOM 3152 N N   . THR A 1 424 ? 93.871  119.132 122.408 1.00 95.18  ?  424 THR A N   1 
ATOM 3153 C CA  . THR A 1 424 ? 94.502  119.340 121.110 1.00 89.24  ?  424 THR A CA  1 
ATOM 3154 C C   . THR A 1 424 ? 95.843  120.012 121.335 1.00 94.79  ?  424 THR A C   1 
ATOM 3155 O O   . THR A 1 424 ? 96.818  119.521 120.858 1.00 96.00  ?  424 THR A O   1 
ATOM 3156 C CB  . THR A 1 424 ? 93.668  120.192 120.138 1.00 90.90  ?  424 THR A CB  1 
ATOM 3157 O OG1 . THR A 1 424 ? 92.444  119.524 119.818 1.00 99.90  ?  424 THR A OG1 1 
ATOM 3158 C CG2 . THR A 1 424 ? 94.429  120.433 118.842 1.00 91.49  ?  424 THR A CG2 1 
ATOM 3159 N N   . SER A 1 425 ? 95.906  121.091 122.111 1.00 95.02  ?  425 SER A N   1 
ATOM 3160 C CA  . SER A 1 425 ? 97.147  121.821 122.353 1.00 89.96  ?  425 SER A CA  1 
ATOM 3161 C C   . SER A 1 425 ? 98.231  120.951 122.961 1.00 87.22  ?  425 SER A C   1 
ATOM 3162 O O   . SER A 1 425 ? 99.386  121.062 122.585 1.00 90.23  ?  425 SER A O   1 
ATOM 3163 C CB  . SER A 1 425 ? 96.888  123.010 123.256 1.00 86.20  ?  425 SER A CB  1 
ATOM 3164 O OG  . SER A 1 425 ? 95.899  123.855 122.705 1.00 98.59  ?  425 SER A OG  1 
ATOM 3165 N N   . LEU A 1 426 ? 97.871  120.086 123.899 1.00 88.80  ?  426 LEU A N   1 
ATOM 3166 C CA  . LEU A 1 426 ? 98.842  119.185 124.507 1.00 86.90  ?  426 LEU A CA  1 
ATOM 3167 C C   . LEU A 1 426 ? 99.291  118.084 123.566 1.00 89.88  ?  426 LEU A C   1 
ATOM 3168 O O   . LEU A 1 426 ? 100.418 117.629 123.662 1.00 100.15 ?  426 LEU A O   1 
ATOM 3169 C CB  . LEU A 1 426 ? 98.313  118.605 125.808 1.00 83.57  ?  426 LEU A CB  1 
ATOM 3170 C CG  . LEU A 1 426 ? 98.214  119.589 126.966 1.00 86.83  ?  426 LEU A CG  1 
ATOM 3171 C CD1 . LEU A 1 426 ? 97.619  118.895 128.172 1.00 89.09  ?  426 LEU A CD1 1 
ATOM 3172 C CD2 . LEU A 1 426 ? 99.582  120.159 127.295 1.00 87.08  ?  426 LEU A CD2 1 
ATOM 3173 N N   . ALA A 1 427 ? 98.445  117.598 122.673 1.00 71.22  ?  427 ALA A N   1 
ATOM 3174 C CA  . ALA A 1 427 ? 98.902  116.607 121.713 1.00 67.61  ?  427 ALA A CA  1 
ATOM 3175 C C   . ALA A 1 427 ? 99.809  117.258 120.715 1.00 80.68  ?  427 ALA A C   1 
ATOM 3176 O O   . ALA A 1 427 ? 100.793 116.670 120.327 1.00 90.89  ?  427 ALA A O   1 
ATOM 3177 C CB  . ALA A 1 427 ? 97.746  115.958 121.009 1.00 86.60  ?  427 ALA A CB  1 
ATOM 3178 N N   . VAL A 1 428 ? 99.478  118.465 120.292 1.00 88.21  ?  428 VAL A N   1 
ATOM 3179 C CA  . VAL A 1 428 ? 100.305 119.202 119.327 1.00 91.00  ?  428 VAL A CA  1 
ATOM 3180 C C   . VAL A 1 428 ? 101.677 119.533 119.888 1.00 94.62  ?  428 VAL A C   1 
ATOM 3181 O O   . VAL A 1 428 ? 102.662 119.354 119.197 1.00 102.59 ?  428 VAL A O   1 
ATOM 3182 C CB  . VAL A 1 428 ? 99.542  120.413 118.723 1.00 89.45  ?  428 VAL A CB  1 
ATOM 3183 C CG1 . VAL A 1 428 ? 100.398 121.278 117.808 1.00 88.29  ?  428 VAL A CG1 1 
ATOM 3184 C CG2 . VAL A 1 428 ? 98.241  119.944 118.093 1.00 92.23  ?  428 VAL A CG2 1 
ATOM 3185 N N   . LEU A 1 429 ? 101.760 119.970 121.136 1.00 87.84  ?  429 LEU A N   1 
ATOM 3186 C CA  . LEU A 1 429 ? 103.054 120.219 121.758 1.00 84.42  ?  429 LEU A CA  1 
ATOM 3187 C C   . LEU A 1 429 ? 103.809 118.918 121.858 1.00 83.28  ?  429 LEU A C   1 
ATOM 3188 O O   . LEU A 1 429 ? 104.998 118.893 121.625 1.00 91.34  ?  429 LEU A O   1 
ATOM 3189 C CB  . LEU A 1 429 ? 102.890 120.840 123.146 1.00 88.90  ?  429 LEU A CB  1 
ATOM 3190 C CG  . LEU A 1 429 ? 104.136 121.121 123.992 1.00 88.56  ?  429 LEU A CG  1 
ATOM 3191 C CD1 . LEU A 1 429 ? 105.097 122.066 123.291 1.00 89.95  ?  429 LEU A CD1 1 
ATOM 3192 C CD2 . LEU A 1 429 ? 103.728 121.677 125.347 1.00 83.00  ?  429 LEU A CD2 1 
ATOM 3193 N N   . GLY A 1 430 ? 103.140 117.832 122.235 1.00 78.66  ?  430 GLY A N   1 
ATOM 3194 C CA  . GLY A 1 430 ? 103.781 116.543 122.376 1.00 83.28  ?  430 GLY A CA  1 
ATOM 3195 C C   . GLY A 1 430 ? 104.353 116.019 121.089 1.00 87.81  ?  430 GLY A C   1 
ATOM 3196 O O   . GLY A 1 430 ? 105.442 115.476 121.095 1.00 96.87  ?  430 GLY A O   1 
ATOM 3197 N N   . LYS A 1 431 ? 103.620 116.145 119.993 1.00 81.74  ?  431 LYS A N   1 
ATOM 3198 C CA  . LYS A 1 431 ? 104.112 115.714 118.687 1.00 79.78  ?  431 LYS A CA  1 
ATOM 3199 C C   . LYS A 1 431 ? 105.295 116.544 118.265 1.00 86.01  ?  431 LYS A C   1 
ATOM 3200 O O   . LYS A 1 431 ? 106.203 116.031 117.638 1.00 92.70  ?  431 LYS A O   1 
ATOM 3201 C CB  . LYS A 1 431 ? 103.011 115.774 117.654 1.00 83.58  ?  431 LYS A CB  1 
ATOM 3202 C CG  . LYS A 1 431 ? 103.317 115.090 116.338 1.00 87.46  ?  431 LYS A CG  1 
ATOM 3203 C CD  . LYS A 1 431 ? 103.795 116.066 115.286 1.00 88.47  ?  431 LYS A CD  1 
ATOM 3204 C CE  . LYS A 1 431 ? 103.640 115.467 113.912 1.00 82.77  ?  431 LYS A CE  1 
ATOM 3205 N NZ  . LYS A 1 431 ? 104.168 116.396 112.896 1.00 85.91  1  431 LYS A NZ  1 
ATOM 3206 N N   . GLY A 1 432 ? 105.280 117.835 118.557 1.00 88.98  ?  432 GLY A N   1 
ATOM 3207 C CA  . GLY A 1 432 ? 106.425 118.679 118.271 1.00 89.40  ?  432 GLY A CA  1 
ATOM 3208 C C   . GLY A 1 432 ? 107.651 118.274 119.044 1.00 93.19  ?  432 GLY A C   1 
ATOM 3209 O O   . GLY A 1 432 ? 108.741 118.275 118.505 1.00 96.61  ?  432 GLY A O   1 
ATOM 3210 N N   . CYS A 1 433 ? 107.484 117.926 120.308 1.00 91.23  ?  433 CYS A N   1 
ATOM 3211 C CA  . CYS A 1 433 ? 108.599 117.477 121.118 1.00 85.81  ?  433 CYS A CA  1 
ATOM 3212 C C   . CYS A 1 433 ? 109.173 116.160 120.610 1.00 90.72  ?  433 CYS A C   1 
ATOM 3213 O O   . CYS A 1 433 ? 110.373 115.994 120.641 1.00 104.35 ?  433 CYS A O   1 
ATOM 3214 C CB  . CYS A 1 433 ? 108.171 117.339 122.567 1.00 86.17  ?  433 CYS A CB  1 
ATOM 3215 S SG  . CYS A 1 433 ? 107.673 118.877 123.348 1.00 106.42 ?  433 CYS A SG  1 
ATOM 3216 N N   . LEU A 1 434 ? 108.345 115.226 120.144 1.00 84.58  ?  434 LEU A N   1 
ATOM 3217 C CA  . LEU A 1 434 ? 108.847 113.964 119.589 1.00 83.09  ?  434 LEU A CA  1 
ATOM 3218 C C   . LEU A 1 434 ? 109.492 114.177 118.241 1.00 90.67  ?  434 LEU A C   1 
ATOM 3219 O O   . LEU A 1 434 ? 110.359 113.406 117.860 1.00 93.35  ?  434 LEU A O   1 
ATOM 3220 C CB  . LEU A 1 434 ? 107.761 112.892 119.529 1.00 84.24  ?  434 LEU A CB  1 
ATOM 3221 C CG  . LEU A 1 434 ? 107.331 112.378 120.903 1.00 87.02  ?  434 LEU A CG  1 
ATOM 3222 C CD1 . LEU A 1 434 ? 105.893 111.900 120.895 1.00 93.39  ?  434 LEU A CD1 1 
ATOM 3223 C CD2 . LEU A 1 434 ? 108.260 111.290 121.422 1.00 87.73  ?  434 LEU A CD2 1 
ATOM 3224 N N   . ALA A 1 435 ? 109.122 115.223 117.505 1.00 93.25  ?  435 ALA A N   1 
ATOM 3225 C CA  . ALA A 1 435 ? 109.812 115.537 116.252 1.00 88.38  ?  435 ALA A CA  1 
ATOM 3226 C C   . ALA A 1 435 ? 111.194 116.042 116.587 1.00 96.57  ?  435 ALA A C   1 
ATOM 3227 O O   . ALA A 1 435 ? 112.152 115.714 115.897 1.00 100.87 ?  435 ALA A O   1 
ATOM 3228 C CB  . ALA A 1 435 ? 109.054 116.575 115.462 1.00 90.60  ?  435 ALA A CB  1 
ATOM 3229 N N   . ALA A 1 436 ? 111.313 116.848 117.635 1.00 95.24  ?  436 ALA A N   1 
ATOM 3230 C CA  . ALA A 1 436 ? 112.618 117.321 118.093 1.00 89.62  ?  436 ALA A CA  1 
ATOM 3231 C C   . ALA A 1 436 ? 113.461 116.159 118.567 1.00 94.38  ?  436 ALA A C   1 
ATOM 3232 O O   . ALA A 1 436 ? 114.656 116.190 118.392 1.00 99.82  ?  436 ALA A O   1 
ATOM 3233 C CB  . ALA A 1 436 ? 112.480 118.349 119.193 1.00 83.03  ?  436 ALA A CB  1 
ATOM 3234 N N   . SER A 1 437 ? 112.871 115.174 119.246 1.00 93.96  ?  437 SER A N   1 
ATOM 3235 C CA  . SER A 1 437 ? 113.612 114.006 119.708 1.00 92.04  ?  437 SER A CA  1 
ATOM 3236 C C   . SER A 1 437 ? 114.162 113.220 118.547 1.00 93.19  ?  437 SER A C   1 
ATOM 3237 O O   . SER A 1 437 ? 115.233 112.674 118.658 1.00 99.65  ?  437 SER A O   1 
ATOM 3238 C CB  . SER A 1 437 ? 112.733 113.086 120.537 1.00 94.30  ?  437 SER A CB  1 
ATOM 3239 O OG  . SER A 1 437 ? 112.206 113.739 121.665 1.00 94.91  ?  437 SER A OG  1 
ATOM 3240 N N   . PHE A 1 438 ? 113.441 113.142 117.440 1.00 92.27  ?  438 PHE A N   1 
ATOM 3241 C CA  . PHE A 1 438 ? 113.946 112.453 116.263 1.00 86.84  ?  438 PHE A CA  1 
ATOM 3242 C C   . PHE A 1 438 ? 115.185 113.144 115.737 1.00 96.39  ?  438 PHE A C   1 
ATOM 3243 O O   . PHE A 1 438 ? 116.167 112.493 115.405 1.00 102.01 ?  438 PHE A O   1 
ATOM 3244 C CB  . PHE A 1 438 ? 112.896 112.406 115.163 1.00 84.91  ?  438 PHE A CB  1 
ATOM 3245 C CG  . PHE A 1 438 ? 112.024 111.190 115.197 1.00 92.46  ?  438 PHE A CG  1 
ATOM 3246 C CD1 . PHE A 1 438 ? 112.523 109.957 114.821 1.00 98.42  ?  438 PHE A CD1 1 
ATOM 3247 C CD2 . PHE A 1 438 ? 110.698 111.285 115.573 1.00 96.63  ?  438 PHE A CD2 1 
ATOM 3248 C CE1 . PHE A 1 438 ? 111.721 108.835 114.840 1.00 99.93  ?  438 PHE A CE1 1 
ATOM 3249 C CE2 . PHE A 1 438 ? 109.889 110.168 115.593 1.00 95.30  ?  438 PHE A CE2 1 
ATOM 3250 C CZ  . PHE A 1 438 ? 110.401 108.941 115.226 1.00 97.21  ?  438 PHE A CZ  1 
ATOM 3251 N N   . ASN A 1 439 ? 115.150 114.467 115.664 1.00 109.63 ?  439 ASN A N   1 
ATOM 3252 C CA  . ASN A 1 439 ? 116.283 115.223 115.144 1.00 110.11 ?  439 ASN A CA  1 
ATOM 3253 C C   . ASN A 1 439 ? 117.500 115.139 116.053 1.00 106.42 ?  439 ASN A C   1 
ATOM 3254 O O   . ASN A 1 439 ? 118.618 115.007 115.573 1.00 108.66 ?  439 ASN A O   1 
ATOM 3255 C CB  . ASN A 1 439 ? 115.895 116.681 114.925 1.00 105.45 ?  439 ASN A CB  1 
ATOM 3256 C CG  . ASN A 1 439 ? 114.723 116.835 113.983 1.00 113.55 ?  439 ASN A CG  1 
ATOM 3257 O OD1 . ASN A 1 439 ? 114.066 117.872 113.962 1.00 112.05 ?  439 ASN A OD1 1 
ATOM 3258 N ND2 . ASN A 1 439 ? 114.450 115.799 113.203 1.00 113.23 ?  439 ASN A ND2 1 
ATOM 3259 N N   . CYS A 1 440 ? 117.296 115.198 117.360 1.00 96.15  ?  440 CYS A N   1 
ATOM 3260 C CA  . CYS A 1 440 ? 118.413 115.111 118.286 1.00 98.96  ?  440 CYS A CA  1 
ATOM 3261 C C   . CYS A 1 440 ? 118.996 113.704 118.347 1.00 104.32 ?  440 CYS A C   1 
ATOM 3262 O O   . CYS A 1 440 ? 120.206 113.548 118.402 1.00 114.10 ?  440 CYS A O   1 
ATOM 3263 C CB  . CYS A 1 440 ? 118.001 115.568 119.681 1.00 104.81 ?  440 CYS A CB  1 
ATOM 3264 S SG  . CYS A 1 440 ? 119.353 115.634 120.871 1.00 117.55 ?  440 CYS A SG  1 
ATOM 3265 N N   . ILE A 1 441 ? 118.155 112.679 118.333 1.00 98.88  ?  441 ILE A N   1 
ATOM 3266 C CA  . ILE A 1 441 ? 118.652 111.311 118.463 1.00 98.91  ?  441 ILE A CA  1 
ATOM 3267 C C   . ILE A 1 441 ? 119.479 110.936 117.245 1.00 100.74 ?  441 ILE A C   1 
ATOM 3268 O O   . ILE A 1 441 ? 120.299 110.029 117.315 1.00 104.61 ?  441 ILE A O   1 
ATOM 3269 C CB  . ILE A 1 441 ? 117.521 110.286 118.688 1.00 96.32  ?  441 ILE A CB  1 
ATOM 3270 C CG1 . ILE A 1 441 ? 118.088 108.996 119.276 1.00 96.72  ?  441 ILE A CG1 1 
ATOM 3271 C CG2 . ILE A 1 441 ? 116.774 110.015 117.392 1.00 99.73  ?  441 ILE A CG2 1 
ATOM 3272 C CD1 . ILE A 1 441 ? 118.895 109.214 120.533 1.00 103.31 ?  441 ILE A CD1 1 
ATOM 3273 N N   . PHE A 1 442 ? 119.324 111.664 116.148 1.00 103.76 ?  442 PHE A N   1 
ATOM 3274 C CA  . PHE A 1 442 ? 120.153 111.408 114.977 1.00 104.19 ?  442 PHE A CA  1 
ATOM 3275 C C   . PHE A 1 442 ? 121.541 111.986 115.205 1.00 106.82 ?  442 PHE A C   1 
ATOM 3276 O O   . PHE A 1 442 ? 122.538 111.294 115.022 1.00 109.17 ?  442 PHE A O   1 
ATOM 3277 C CB  . PHE A 1 442 ? 119.518 112.003 113.733 1.00 102.78 ?  442 PHE A CB  1 
ATOM 3278 C CG  . PHE A 1 442 ? 120.173 111.582 112.456 1.00 108.30 ?  442 PHE A CG  1 
ATOM 3279 C CD1 . PHE A 1 442 ? 121.215 112.317 111.922 1.00 108.17 ?  442 PHE A CD1 1 
ATOM 3280 C CD2 . PHE A 1 442 ? 119.739 110.456 111.782 1.00 109.82 ?  442 PHE A CD2 1 
ATOM 3281 C CE1 . PHE A 1 442 ? 121.817 111.933 110.740 1.00 107.95 ?  442 PHE A CE1 1 
ATOM 3282 C CE2 . PHE A 1 442 ? 120.334 110.066 110.600 1.00 107.90 ?  442 PHE A CE2 1 
ATOM 3283 C CZ  . PHE A 1 442 ? 121.375 110.806 110.077 1.00 106.21 ?  442 PHE A CZ  1 
ATOM 3284 N N   . LEU A 1 443 ? 121.622 113.244 115.617 1.00 107.81 ?  443 LEU A N   1 
ATOM 3285 C CA  . LEU A 1 443 ? 122.914 113.843 115.929 1.00 104.92 ?  443 LEU A CA  1 
ATOM 3286 C C   . LEU A 1 443 ? 123.550 113.148 117.111 1.00 107.61 ?  443 LEU A C   1 
ATOM 3287 O O   . LEU A 1 443 ? 124.728 112.824 117.081 1.00 113.54 ?  443 LEU A O   1 
ATOM 3288 C CB  . LEU A 1 443 ? 122.755 115.322 116.256 1.00 100.41 ?  443 LEU A CB  1 
ATOM 3289 C CG  . LEU A 1 443 ? 122.451 116.322 115.143 1.00 102.20 ?  443 LEU A CG  1 
ATOM 3290 C CD1 . LEU A 1 443 ? 121.308 115.865 114.250 1.00 107.21 ?  443 LEU A CD1 1 
ATOM 3291 C CD2 . LEU A 1 443 ? 122.152 117.683 115.748 1.00 103.11 ?  443 LEU A CD2 1 
ATOM 3292 N N   . TYR A 1 444 ? 122.777 112.909 118.155 1.00 100.98 ?  444 TYR A N   1 
ATOM 3293 C CA  . TYR A 1 444 ? 123.298 112.279 119.346 1.00 96.19  ?  444 TYR A CA  1 
ATOM 3294 C C   . TYR A 1 444 ? 123.873 110.926 119.013 1.00 104.97 ?  444 TYR A C   1 
ATOM 3295 O O   . TYR A 1 444 ? 124.908 110.556 119.543 1.00 110.10 ?  444 TYR A O   1 
ATOM 3296 C CB  . TYR A 1 444 ? 122.170 112.126 120.360 1.00 100.57 ?  444 TYR A CB  1 
ATOM 3297 C CG  . TYR A 1 444 ? 122.590 112.205 121.800 1.00 101.27 ?  444 TYR A CG  1 
ATOM 3298 C CD1 . TYR A 1 444 ? 122.877 113.417 122.390 1.00 102.35 ?  444 TYR A CD1 1 
ATOM 3299 C CD2 . TYR A 1 444 ? 122.661 111.074 122.580 1.00 97.59  ?  444 TYR A CD2 1 
ATOM 3300 C CE1 . TYR A 1 444 ? 123.274 113.493 123.708 1.00 99.59  ?  444 TYR A CE1 1 
ATOM 3301 C CE2 . TYR A 1 444 ? 123.048 111.141 123.900 1.00 98.87  ?  444 TYR A CE2 1 
ATOM 3302 C CZ  . TYR A 1 444 ? 123.352 112.352 124.457 1.00 100.90 ?  444 TYR A CZ  1 
ATOM 3303 O OH  . TYR A 1 444 ? 123.732 112.412 125.772 1.00 106.85 ?  444 TYR A OH  1 
ATOM 3304 N N   . THR A 1 445 ? 123.228 110.178 118.126 1.00 104.29 ?  445 THR A N   1 
ATOM 3305 C CA  . THR A 1 445 ? 123.673 108.812 117.844 1.00 102.71 ?  445 THR A CA  1 
ATOM 3306 C C   . THR A 1 445 ? 124.842 108.729 116.886 1.00 100.33 ?  445 THR A C   1 
ATOM 3307 O O   . THR A 1 445 ? 125.418 107.666 116.711 1.00 103.59 ?  445 THR A O   1 
ATOM 3308 C CB  . THR A 1 445 ? 122.534 107.955 117.274 1.00 101.93 ?  445 THR A CB  1 
ATOM 3309 O OG1 . THR A 1 445 ? 122.860 106.571 117.424 1.00 102.72 ?  445 THR A OG1 1 
ATOM 3310 C CG2 . THR A 1 445 ? 122.324 108.259 115.805 1.00 104.88 ?  445 THR A CG2 1 
ATOM 3311 N N   . GLY A 1 446 ? 125.198 109.834 116.256 1.00 102.75 ?  446 GLY A N   1 
ATOM 3312 C CA  . GLY A 1 446 ? 126.355 109.835 115.386 1.00 106.01 ?  446 GLY A CA  1 
ATOM 3313 C C   . GLY A 1 446 ? 127.556 110.316 116.150 1.00 109.73 ?  446 GLY A C   1 
ATOM 3314 O O   . GLY A 1 446 ? 128.675 109.896 115.889 1.00 112.65 ?  446 GLY A O   1 
ATOM 3315 N N   . GLU A 1 447 ? 127.330 111.205 117.098 1.00 117.09 ?  447 GLU A N   1 
ATOM 3316 C CA  . GLU A 1 447 ? 128.412 111.725 117.904 1.00 112.21 ?  447 GLU A CA  1 
ATOM 3317 C C   . GLU A 1 447 ? 128.828 110.746 118.979 1.00 117.25 ?  447 GLU A C   1 
ATOM 3318 O O   . GLU A 1 447 ? 129.956 110.795 119.451 1.00 120.55 ?  447 GLU A O   1 
ATOM 3319 C CB  . GLU A 1 447 ? 127.985 113.037 118.550 1.00 112.29 ?  447 GLU A CB  1 
ATOM 3320 C CG  . GLU A 1 447 ? 127.661 114.143 117.562 1.00 116.50 ?  447 GLU A CG  1 
ATOM 3321 C CD  . GLU A 1 447 ? 127.131 115.390 118.241 1.00 122.36 ?  447 GLU A CD  1 
ATOM 3322 O OE1 . GLU A 1 447 ? 127.223 116.481 117.644 1.00 125.61 ?  447 GLU A OE1 1 
ATOM 3323 O OE2 . GLU A 1 447 ? 126.628 115.284 119.376 1.00 122.32 -1 447 GLU A OE2 1 
ATOM 3324 N N   . LEU A 1 448 ? 127.925 109.866 119.392 1.00 111.32 ?  448 LEU A N   1 
ATOM 3325 C CA  . LEU A 1 448 ? 128.251 108.952 120.462 1.00 107.11 ?  448 LEU A CA  1 
ATOM 3326 C C   . LEU A 1 448 ? 129.061 107.795 119.956 1.00 110.19 ?  448 LEU A C   1 
ATOM 3327 O O   . LEU A 1 448 ? 129.970 107.367 120.649 1.00 113.18 ?  448 LEU A O   1 
ATOM 3328 C CB  . LEU A 1 448 ? 126.981 108.458 121.147 1.00 106.82 ?  448 LEU A CB  1 
ATOM 3329 C CG  . LEU A 1 448 ? 126.260 109.510 121.984 1.00 102.42 ?  448 LEU A CG  1 
ATOM 3330 C CD1 . LEU A 1 448 ? 124.862 109.047 122.342 1.00 107.52 ?  448 LEU A CD1 1 
ATOM 3331 C CD2 . LEU A 1 448 ? 127.060 109.853 123.215 1.00 104.02 ?  448 LEU A CD2 1 
ATOM 3332 N N   . TYR A 1 449 ? 128.778 107.299 118.752 1.00 111.66 ?  449 TYR A N   1 
ATOM 3333 C CA  . TYR A 1 449 ? 129.475 106.093 118.276 1.00 109.36 ?  449 TYR A CA  1 
ATOM 3334 C C   . TYR A 1 449 ? 130.866 106.330 117.697 1.00 112.07 ?  449 TYR A C   1 
ATOM 3335 O O   . TYR A 1 449 ? 131.107 107.368 117.093 1.00 114.72 ?  449 TYR A O   1 
ATOM 3336 C CB  . TYR A 1 449 ? 128.619 105.370 117.246 1.00 107.32 ?  449 TYR A CB  1 
ATOM 3337 C CG  . TYR A 1 449 ? 127.506 104.541 117.818 1.00 106.08 ?  449 TYR A CG  1 
ATOM 3338 C CD1 . TYR A 1 449 ? 127.769 103.489 118.678 1.00 107.25 ?  449 TYR A CD1 1 
ATOM 3339 C CD2 . TYR A 1 449 ? 126.194 104.792 117.476 1.00 107.63 ?  449 TYR A CD2 1 
ATOM 3340 C CE1 . TYR A 1 449 ? 126.748 102.722 119.196 1.00 108.26 ?  449 TYR A CE1 1 
ATOM 3341 C CE2 . TYR A 1 449 ? 125.169 104.034 117.989 1.00 109.93 ?  449 TYR A CE2 1 
ATOM 3342 C CZ  . TYR A 1 449 ? 125.451 103.000 118.844 1.00 110.66 ?  449 TYR A CZ  1 
ATOM 3343 O OH  . TYR A 1 449 ? 124.418 102.251 119.344 1.00 114.86 ?  449 TYR A OH  1 
ATOM 3344 N N   . PRO A 1 450 ? 131.818 105.369 117.895 1.00 115.87 ?  450 PRO A N   1 
ATOM 3345 C CA  . PRO A 1 450 ? 133.128 105.536 117.261 1.00 115.36 ?  450 PRO A CA  1 
ATOM 3346 C C   . PRO A 1 450 ? 133.052 105.334 115.782 1.00 118.66 ?  450 PRO A C   1 
ATOM 3347 O O   . PRO A 1 450 ? 132.140 104.665 115.334 1.00 124.60 ?  450 PRO A O   1 
ATOM 3348 C CB  . PRO A 1 450 ? 133.975 104.445 117.905 1.00 114.81 ?  450 PRO A CB  1 
ATOM 3349 C CG  . PRO A 1 450 ? 133.311 104.176 119.196 1.00 114.52 ?  450 PRO A CG  1 
ATOM 3350 C CD  . PRO A 1 450 ? 131.870 104.214 118.807 1.00 114.78 ?  450 PRO A CD  1 
ATOM 3351 N N   . THR A 1 451 ? 133.995 105.876 115.033 1.00 122.80 ?  451 THR A N   1 
ATOM 3352 C CA  . THR A 1 451 ? 133.937 105.814 113.580 1.00 127.12 ?  451 THR A CA  1 
ATOM 3353 C C   . THR A 1 451 ? 133.751 104.399 113.018 1.00 129.34 ?  451 THR A C   1 
ATOM 3354 O O   . THR A 1 451 ? 133.001 104.219 112.060 1.00 129.64 ?  451 THR A O   1 
ATOM 3355 C CB  . THR A 1 451 ? 135.190 106.463 112.973 1.00 126.33 ?  451 THR A CB  1 
ATOM 3356 O OG1 . THR A 1 451 ? 135.384 107.748 113.575 1.00 125.22 ?  451 THR A OG1 1 
ATOM 3357 C CG2 . THR A 1 451 ? 135.050 106.629 111.460 1.00 124.72 ?  451 THR A CG2 1 
ATOM 3358 N N   . MET A 1 452 ? 134.406 103.402 113.608 1.00 127.35 ?  452 MET A N   1 
ATOM 3359 C CA  . MET A 1 452 ? 134.258 102.039 113.118 1.00 123.88 ?  452 MET A CA  1 
ATOM 3360 C C   . MET A 1 452 ? 132.813 101.565 113.095 1.00 127.88 ?  452 MET A C   1 
ATOM 3361 O O   . MET A 1 452 ? 132.354 101.062 112.075 1.00 133.20 ?  452 MET A O   1 
ATOM 3362 C CB  . MET A 1 452 ? 135.101 101.095 113.965 1.00 123.66 ?  452 MET A CB  1 
ATOM 3363 C CG  . MET A 1 452 ? 136.522 101.581 114.183 1.00 129.17 ?  452 MET A CG  1 
ATOM 3364 S SD  . MET A 1 452 ? 137.369 101.956 112.635 1.00 129.18 ?  452 MET A SD  1 
ATOM 3365 C CE  . MET A 1 452 ? 137.474 100.330 111.891 1.00 127.22 ?  452 MET A CE  1 
ATOM 3366 N N   . ILE A 1 453 ? 132.072 101.740 114.197 1.00 113.03 ?  453 ILE A N   1 
ATOM 3367 C CA  . ILE A 1 453 ? 130.705 101.216 114.312 1.00 107.89 ?  453 ILE A CA  1 
ATOM 3368 C C   . ILE A 1 453 ? 129.636 102.304 114.202 1.00 105.42 ?  453 ILE A C   1 
ATOM 3369 O O   . ILE A 1 453 ? 128.511 102.081 114.603 1.00 113.38 ?  453 ILE A O   1 
ATOM 3370 C CB  . ILE A 1 453 ? 130.599 100.459 115.660 1.00 104.72 ?  453 ILE A CB  1 
ATOM 3371 C CG1 . ILE A 1 453 ? 129.557 99.332  115.640 1.00 109.76 ?  453 ILE A CG1 1 
ATOM 3372 C CG2 . ILE A 1 453 ? 130.331 101.413 116.825 1.00 111.13 ?  453 ILE A CG2 1 
ATOM 3373 C CD1 . ILE A 1 453 ? 129.911 98.109  114.824 1.00 109.38 ?  453 ILE A CD1 1 
ATOM 3374 N N   . ARG A 1 454 ? 129.953 103.467 113.637 1.00 107.69 ?  454 ARG A N   1 
ATOM 3375 C CA  . ARG A 1 454 ? 128.991 104.575 113.610 1.00 110.57 ?  454 ARG A CA  1 
ATOM 3376 C C   . ARG A 1 454 ? 127.879 104.405 112.590 1.00 115.48 ?  454 ARG A C   1 
ATOM 3377 O O   . ARG A 1 454 ? 126.762 104.845 112.845 1.00 119.61 ?  454 ARG A O   1 
ATOM 3378 C CB  . ARG A 1 454 ? 129.707 105.891 113.354 1.00 111.58 ?  454 ARG A CB  1 
ATOM 3379 C CG  . ARG A 1 454 ? 128.875 107.152 113.533 1.00 114.06 ?  454 ARG A CG  1 
ATOM 3380 C CD  . ARG A 1 454 ? 129.748 108.372 113.297 1.00 114.07 ?  454 ARG A CD  1 
ATOM 3381 N NE  . ARG A 1 454 ? 130.834 108.434 114.276 1.00 111.15 ?  454 ARG A NE  1 
ATOM 3382 C CZ  . ARG A 1 454 ? 132.013 109.042 114.114 1.00 113.90 ?  454 ARG A CZ  1 
ATOM 3383 N NH1 . ARG A 1 454 ? 132.333 109.687 112.990 1.00 117.45 1  454 ARG A NH1 1 
ATOM 3384 N NH2 . ARG A 1 454 ? 132.899 108.997 115.103 1.00 111.69 ?  454 ARG A NH2 1 
ATOM 3385 N N   . GLN A 1 455 ? 128.166 103.786 111.443 1.00 119.50 ?  455 GLN A N   1 
ATOM 3386 C CA  . GLN A 1 455 ? 127.127 103.550 110.446 1.00 119.34 ?  455 GLN A CA  1 
ATOM 3387 C C   . GLN A 1 455 ? 126.278 102.362 110.838 1.00 117.39 ?  455 GLN A C   1 
ATOM 3388 O O   . GLN A 1 455 ? 125.073 102.366 110.617 1.00 121.70 ?  455 GLN A O   1 
ATOM 3389 C CB  . GLN A 1 455 ? 127.712 103.389 109.047 1.00 117.09 ?  455 GLN A CB  1 
ATOM 3390 C CG  . GLN A 1 455 ? 127.887 104.701 108.300 1.00 118.74 ?  455 GLN A CG  1 
ATOM 3391 C CD  . GLN A 1 455 ? 128.946 105.596 108.913 1.00 124.78 ?  455 GLN A CD  1 
ATOM 3392 O OE1 . GLN A 1 455 ? 128.697 106.769 109.193 1.00 123.86 ?  455 GLN A OE1 1 
ATOM 3393 N NE2 . GLN A 1 455 ? 130.134 105.044 109.133 1.00 122.28 ?  455 GLN A NE2 1 
ATOM 3394 N N   . THR A 1 456 ? 126.890 101.343 111.423 1.00 106.06 ?  456 THR A N   1 
ATOM 3395 C CA  . THR A 1 456 ? 126.125 100.207 111.912 1.00 103.54 ?  456 THR A CA  1 
ATOM 3396 C C   . THR A 1 456 ? 125.217 100.708 113.011 1.00 106.27 ?  456 THR A C   1 
ATOM 3397 O O   . THR A 1 456 ? 124.064 100.310 113.095 1.00 110.96 ?  456 THR A O   1 
ATOM 3398 C CB  . THR A 1 456 ? 127.040 99.107  112.466 1.00 105.27 ?  456 THR A CB  1 
ATOM 3399 O OG1 . THR A 1 456 ? 128.020 98.760  111.482 1.00 107.86 ?  456 THR A OG1 1 
ATOM 3400 C CG2 . THR A 1 456 ? 126.244 97.875  112.827 1.00 108.82 ?  456 THR A CG2 1 
ATOM 3401 N N   . GLY A 1 457 ? 125.726 101.591 113.867 1.00 103.19 ?  457 GLY A N   1 
ATOM 3402 C CA  . GLY A 1 457 ? 124.954 102.083 114.989 1.00 101.47 ?  457 GLY A CA  1 
ATOM 3403 C C   . GLY A 1 457 ? 123.793 102.973 114.648 1.00 99.96  ?  457 GLY A C   1 
ATOM 3404 O O   . GLY A 1 457 ? 122.810 102.982 115.373 1.00 111.06 ?  457 GLY A O   1 
ATOM 3405 N N   . MET A 1 458 ? 123.899 103.728 113.568 1.00 98.20  ?  458 MET A N   1 
ATOM 3406 C CA  . MET A 1 458 ? 122.798 104.580 113.134 1.00 101.06 ?  458 MET A CA  1 
ATOM 3407 C C   . MET A 1 458 ? 121.760 103.699 112.464 1.00 109.26 ?  458 MET A C   1 
ATOM 3408 O O   . MET A 1 458 ? 120.583 104.000 112.561 1.00 116.90 ?  458 MET A O   1 
ATOM 3409 C CB  . MET A 1 458 ? 123.288 105.694 112.219 1.00 104.25 ?  458 MET A CB  1 
ATOM 3410 C CG  . MET A 1 458 ? 122.389 106.920 112.180 1.00 109.72 ?  458 MET A CG  1 
ATOM 3411 S SD  . MET A 1 458 ? 123.203 108.318 111.389 1.00 128.42 ?  458 MET A SD  1 
ATOM 3412 C CE  . MET A 1 458 ? 124.160 109.005 112.735 1.00 111.13 ?  458 MET A CE  1 
ATOM 3413 N N   . GLY A 1 459 ? 122.162 102.648 111.746 1.00 109.08 ?  459 GLY A N   1 
ATOM 3414 C CA  . GLY A 1 459 ? 121.223 101.685 111.213 1.00 106.25 ?  459 GLY A CA  1 
ATOM 3415 C C   . GLY A 1 459 ? 120.488 100.877 112.252 1.00 109.11 ?  459 GLY A C   1 
ATOM 3416 O O   . GLY A 1 459 ? 119.294 100.659 112.109 1.00 113.37 ?  459 GLY A O   1 
ATOM 3417 N N   . MET A 1 460 ? 121.181 100.421 113.291 1.00 102.31 ?  460 MET A N   1 
ATOM 3418 C CA  . MET A 1 460 ? 120.516 99.699  114.373 1.00 100.50 ?  460 MET A CA  1 
ATOM 3419 C C   . MET A 1 460 ? 119.538 100.595 115.099 1.00 105.03 ?  460 MET A C   1 
ATOM 3420 O O   . MET A 1 460 ? 118.469 100.157 115.486 1.00 112.62 ?  460 MET A O   1 
ATOM 3421 C CB  . MET A 1 460 ? 121.508 99.079  115.345 1.00 100.41 ?  460 MET A CB  1 
ATOM 3422 C CG  . MET A 1 460 ? 122.241 97.874  114.792 1.00 103.49 ?  460 MET A CG  1 
ATOM 3423 S SD  . MET A 1 460 ? 121.100 96.618  114.193 1.00 116.54 ?  460 MET A SD  1 
ATOM 3424 C CE  . MET A 1 460 ? 120.248 96.162  115.700 1.00 110.48 ?  460 MET A CE  1 
ATOM 3425 N N   . GLY A 1 461 ? 119.903 101.848 115.302 1.00 100.69 ?  461 GLY A N   1 
ATOM 3426 C CA  . GLY A 1 461 ? 118.990 102.771 115.924 1.00 97.16  ?  461 GLY A CA  1 
ATOM 3427 C C   . GLY A 1 461 ? 117.757 102.982 115.082 1.00 102.93 ?  461 GLY A C   1 
ATOM 3428 O O   . GLY A 1 461 ? 116.655 102.980 115.601 1.00 116.06 ?  461 GLY A O   1 
ATOM 3429 N N   . SER A 1 462 ? 117.916 103.168 113.783 1.00 90.02  ?  462 SER A N   1 
ATOM 3430 C CA  . SER A 1 462 ? 116.768 103.328 112.914 1.00 90.97  ?  462 SER A CA  1 
ATOM 3431 C C   . SER A 1 462 ? 115.942 102.060 112.865 1.00 99.68  ?  462 SER A C   1 
ATOM 3432 O O   . SER A 1 462 ? 114.738 102.129 112.709 1.00 102.61 ?  462 SER A O   1 
ATOM 3433 C CB  . SER A 1 462 ? 117.207 103.738 111.524 1.00 99.52  ?  462 SER A CB  1 
ATOM 3434 O OG  . SER A 1 462 ? 116.089 103.993 110.696 1.00 107.99 ?  462 SER A OG  1 
ATOM 3435 N N   . THR A 1 463 ? 116.571 100.896 112.978 1.00 97.24  ?  463 THR A N   1 
ATOM 3436 C CA  . THR A 1 463 ? 115.827 99.638  113.032 1.00 93.19  ?  463 THR A CA  1 
ATOM 3437 C C   . THR A 1 463 ? 114.964 99.585  114.277 1.00 96.32  ?  463 THR A C   1 
ATOM 3438 O O   . THR A 1 463 ? 113.820 99.157  114.221 1.00 102.37 ?  463 THR A O   1 
ATOM 3439 C CB  . THR A 1 463 ? 116.764 98.420  112.999 1.00 92.59  ?  463 THR A CB  1 
ATOM 3440 O OG1 . THR A 1 463 ? 117.433 98.366  111.735 1.00 95.73  ?  463 THR A OG1 1 
ATOM 3441 C CG2 . THR A 1 463 ? 116.014 97.125  113.219 1.00 89.63  ?  463 THR A CG2 1 
ATOM 3442 N N   . MET A 1 464 ? 115.491 100.037 115.402 1.00 93.32  ?  464 MET A N   1 
ATOM 3443 C CA  . MET A 1 464 ? 114.708 100.059 116.620 1.00 87.93  ?  464 MET A CA  1 
ATOM 3444 C C   . MET A 1 464 ? 113.594 101.064 116.499 1.00 92.61  ?  464 MET A C   1 
ATOM 3445 O O   . MET A 1 464 ? 112.555 100.895 117.113 1.00 104.67 ?  464 MET A O   1 
ATOM 3446 C CB  . MET A 1 464 ? 115.579 100.338 117.825 1.00 83.02  ?  464 MET A CB  1 
ATOM 3447 C CG  . MET A 1 464 ? 116.573 99.237  118.125 1.00 94.25  ?  464 MET A CG  1 
ATOM 3448 S SD  . MET A 1 464 ? 115.751 97.666  118.425 1.00 113.82 ?  464 MET A SD  1 
ATOM 3449 C CE  . MET A 1 464 ? 114.733 98.076  119.839 1.00 94.15  ?  464 MET A CE  1 
ATOM 3450 N N   . ALA A 1 465 ? 113.775 102.104 115.700 1.00 83.11  ?  465 ALA A N   1 
ATOM 3451 C CA  . ALA A 1 465 ? 112.693 103.049 115.477 1.00 82.04  ?  465 ALA A CA  1 
ATOM 3452 C C   . ALA A 1 465 ? 111.586 102.376 114.700 1.00 86.79  ?  465 ALA A C   1 
ATOM 3453 O O   . ALA A 1 465 ? 110.420 102.574 114.983 1.00 93.62  ?  465 ALA A O   1 
ATOM 3454 C CB  . ALA A 1 465 ? 113.176 104.264 114.732 1.00 80.13  ?  465 ALA A CB  1 
ATOM 3455 N N   . ARG A 1 466 ? 111.941 101.561 113.722 1.00 94.57  ?  466 ARG A N   1 
ATOM 3456 C CA  . ARG A 1 466 ? 110.939 100.849 112.955 1.00 88.20  ?  466 ARG A CA  1 
ATOM 3457 C C   . ARG A 1 466 ? 110.259 99.780  113.782 1.00 89.89  ?  466 ARG A C   1 
ATOM 3458 O O   . ARG A 1 466 ? 109.092 99.520  113.565 1.00 97.24  ?  466 ARG A O   1 
ATOM 3459 C CB  . ARG A 1 466 ? 111.532 100.289 111.675 1.00 89.32  ?  466 ARG A CB  1 
ATOM 3460 C CG  . ARG A 1 466 ? 111.936 101.368 110.689 1.00 86.51  ?  466 ARG A CG  1 
ATOM 3461 C CD  . ARG A 1 466 ? 112.544 100.770 109.437 1.00 95.19  ?  466 ARG A CD  1 
ATOM 3462 N NE  . ARG A 1 466 ? 113.887 100.252 109.659 1.00 100.99 ?  466 ARG A NE  1 
ATOM 3463 C CZ  . ARG A 1 466 ? 114.995 100.912 109.346 1.00 101.97 ?  466 ARG A CZ  1 
ATOM 3464 N NH1 . ARG A 1 466 ? 114.915 102.110 108.787 1.00 99.10  1  466 ARG A NH1 1 
ATOM 3465 N NH2 . ARG A 1 466 ? 116.182 100.370 109.576 1.00 94.34  ?  466 ARG A NH2 1 
ATOM 3466 N N   . VAL A 1 467 ? 110.943 99.189  114.754 1.00 81.57  ?  467 VAL A N   1 
ATOM 3467 C CA  . VAL A 1 467 ? 110.284 98.237  115.645 1.00 80.09  ?  467 VAL A CA  1 
ATOM 3468 C C   . VAL A 1 467 ? 109.266 98.998  116.480 1.00 81.37  ?  467 VAL A C   1 
ATOM 3469 O O   . VAL A 1 467 ? 108.206 98.480  116.779 1.00 84.05  ?  467 VAL A O   1 
ATOM 3470 C CB  . VAL A 1 467 ? 111.283 97.467  116.519 1.00 72.57  ?  467 VAL A CB  1 
ATOM 3471 C CG1 . VAL A 1 467 ? 110.572 96.583  117.526 1.00 75.85  ?  467 VAL A CG1 1 
ATOM 3472 C CG2 . VAL A 1 467 ? 112.201 96.631  115.650 1.00 81.04  ?  467 VAL A CG2 1 
ATOM 3473 N N   . GLY A 1 468 ? 109.549 100.250 116.812 1.00 85.54  ?  468 GLY A N   1 
ATOM 3474 C CA  . GLY A 1 468 ? 108.611 101.062 117.563 1.00 84.14  ?  468 GLY A CA  1 
ATOM 3475 C C   . GLY A 1 468 ? 107.346 101.297 116.793 1.00 91.86  ?  468 GLY A C   1 
ATOM 3476 O O   . GLY A 1 468 ? 106.266 101.233 117.350 1.00 100.85 ?  468 GLY A O   1 
ATOM 3477 N N   . SER A 1 469 ? 107.462 101.586 115.514 1.00 86.35  ?  469 SER A N   1 
ATOM 3478 C CA  . SER A 1 469 ? 106.294 101.751 114.673 1.00 83.40  ?  469 SER A CA  1 
ATOM 3479 C C   . SER A 1 469 ? 105.475 100.479 114.508 1.00 85.89  ?  469 SER A C   1 
ATOM 3480 O O   . SER A 1 469 ? 104.289 100.573 114.322 1.00 84.58  ?  469 SER A O   1 
ATOM 3481 C CB  . SER A 1 469 ? 106.685 102.337 113.331 1.00 85.70  ?  469 SER A CB  1 
ATOM 3482 O OG  . SER A 1 469 ? 107.452 101.427 112.571 1.00 93.30  ?  469 SER A OG  1 
ATOM 3483 N N   . ILE A 1 470 ? 106.096 99.309  114.430 1.00 82.46  ?  470 ILE A N   1 
ATOM 3484 C CA  . ILE A 1 470 ? 105.350 98.045  114.394 1.00 75.60  ?  470 ILE A CA  1 
ATOM 3485 C C   . ILE A 1 470 ? 104.607 97.802  115.701 1.00 82.86  ?  470 ILE A C   1 
ATOM 3486 O O   . ILE A 1 470 ? 103.471 97.346  115.688 1.00 88.05  ?  470 ILE A O   1 
ATOM 3487 C CB  . ILE A 1 470 ? 106.277 96.848  114.122 1.00 77.70  ?  470 ILE A CB  1 
ATOM 3488 C CG1 . ILE A 1 470 ? 107.064 97.055  112.837 1.00 78.44  ?  470 ILE A CG1 1 
ATOM 3489 C CG2 . ILE A 1 470 ? 105.496 95.549  114.058 1.00 71.39  ?  470 ILE A CG2 1 
ATOM 3490 C CD1 . ILE A 1 470 ? 108.167 96.043  112.656 1.00 75.35  ?  470 ILE A CD1 1 
ATOM 3491 N N   . VAL A 1 471 ? 105.238 98.095  116.842 1.00 87.70  ?  471 VAL A N   1 
ATOM 3492 C CA  . VAL A 1 471 ? 104.637 97.809  118.151 1.00 81.58  ?  471 VAL A CA  1 
ATOM 3493 C C   . VAL A 1 471 ? 103.565 98.820  118.518 1.00 87.50  ?  471 VAL A C   1 
ATOM 3494 O O   . VAL A 1 471 ? 102.654 98.495  119.258 1.00 92.30  ?  471 VAL A O   1 
ATOM 3495 C CB  . VAL A 1 471 ? 105.711 97.727  119.264 1.00 78.63  ?  471 VAL A CB  1 
ATOM 3496 C CG1 . VAL A 1 471 ? 105.091 97.509  120.637 1.00 86.55  ?  471 VAL A CG1 1 
ATOM 3497 C CG2 . VAL A 1 471 ? 106.691 96.593  118.990 1.00 84.19  ?  471 VAL A CG2 1 
ATOM 3498 N N   . SER A 1 472 ? 103.651 100.039 118.009 1.00 88.48  ?  472 SER A N   1 
ATOM 3499 C CA  . SER A 1 472 ? 102.685 101.057 118.397 1.00 82.71  ?  472 SER A CA  1 
ATOM 3500 C C   . SER A 1 472 ? 101.240 100.739 118.014 1.00 97.82  ?  472 SER A C   1 
ATOM 3501 O O   . SER A 1 472 ? 100.397 100.746 118.874 1.00 102.33 ?  472 SER A O   1 
ATOM 3502 C CB  . SER A 1 472 ? 103.098 102.434 117.875 1.00 80.52  ?  472 SER A CB  1 
ATOM 3503 O OG  . SER A 1 472 ? 102.003 103.319 117.895 1.00 92.08  ?  472 SER A OG  1 
ATOM 3504 N N   . PRO A 1 473 ? 100.949 100.325 116.772 1.00 95.52  ?  473 PRO A N   1 
ATOM 3505 C CA  . PRO A 1 473 ? 99.552  99.982  116.508 1.00 87.51  ?  473 PRO A CA  1 
ATOM 3506 C C   . PRO A 1 473 ? 99.063  98.813  117.353 1.00 96.15  ?  473 PRO A C   1 
ATOM 3507 O O   . PRO A 1 473 ? 97.886  98.784  117.671 1.00 102.55 ?  473 PRO A O   1 
ATOM 3508 C CB  . PRO A 1 473 ? 99.571  99.582  115.053 1.00 93.00  ?  473 PRO A CB  1 
ATOM 3509 C CG  . PRO A 1 473 ? 100.675 100.351 114.459 1.00 92.72  ?  473 PRO A CG  1 
ATOM 3510 C CD  . PRO A 1 473 ? 101.715 100.410 115.526 1.00 94.28  ?  473 PRO A CD  1 
ATOM 3511 N N   . LEU A 1 474 ? 99.929  97.866  117.692 1.00 94.62  ?  474 LEU A N   1 
ATOM 3512 C CA  . LEU A 1 474 ? 99.546  96.740  118.511 1.00 97.58  ?  474 LEU A CA  1 
ATOM 3513 C C   . LEU A 1 474 ? 99.145  97.228  119.898 1.00 104.58 ?  474 LEU A C   1 
ATOM 3514 O O   . LEU A 1 474 ? 98.198  96.721  120.476 1.00 112.40 ?  474 LEU A O   1 
ATOM 3515 C CB  . LEU A 1 474 ? 100.663 95.711  118.555 1.00 100.15 ?  474 LEU A CB  1 
ATOM 3516 C CG  . LEU A 1 474 ? 101.128 95.230  117.184 1.00 102.58 ?  474 LEU A CG  1 
ATOM 3517 C CD1 . LEU A 1 474 ? 102.256 94.224  117.334 1.00 102.13 ?  474 LEU A CD1 1 
ATOM 3518 C CD2 . LEU A 1 474 ? 99.968  94.629  116.407 1.00 103.30 ?  474 LEU A CD2 1 
ATOM 3519 N N   . VAL A 1 475 ? 99.855  98.207  120.440 1.00 91.92  ?  475 VAL A N   1 
ATOM 3520 C CA  . VAL A 1 475 ? 99.493  98.789  121.732 1.00 87.53  ?  475 VAL A CA  1 
ATOM 3521 C C   . VAL A 1 475 ? 98.153  99.495  121.657 1.00 99.37  ?  475 VAL A C   1 
ATOM 3522 O O   . VAL A 1 475 ? 97.354  99.405  122.571 1.00 103.81 ?  475 VAL A O   1 
ATOM 3523 C CB  . VAL A 1 475 ? 100.595 99.719  122.257 1.00 94.88  ?  475 VAL A CB  1 
ATOM 3524 C CG1 . VAL A 1 475 ? 100.065 100.699 123.288 1.00 100.58 ?  475 VAL A CG1 1 
ATOM 3525 C CG2 . VAL A 1 475 ? 101.728 98.889  122.831 1.00 96.70  ?  475 VAL A CG2 1 
ATOM 3526 N N   . SER A 1 476 ? 97.884  100.174 120.552 1.00 98.85  ?  476 SER A N   1 
ATOM 3527 C CA  . SER A 1 476 ? 96.620  100.883 120.387 1.00 99.94  ?  476 SER A CA  1 
ATOM 3528 C C   . SER A 1 476 ? 95.468  99.916  120.441 1.00 98.33  ?  476 SER A C   1 
ATOM 3529 O O   . SER A 1 476 ? 94.402  100.252 120.930 1.00 94.16  ?  476 SER A O   1 
ATOM 3530 C CB  . SER A 1 476 ? 96.589  101.646 119.076 1.00 94.15  ?  476 SER A CB  1 
ATOM 3531 O OG  . SER A 1 476 ? 95.344  102.289 118.898 1.00 100.78 ?  476 SER A OG  1 
ATOM 3532 N N   . MET A 1 477 ? 95.661  98.660  120.046 1.00 104.56 ?  477 MET A N   1 
ATOM 3533 C CA  . MET A 1 477 ? 94.596  97.655  120.142 1.00 103.18 ?  477 MET A CA  1 
ATOM 3534 C C   . MET A 1 477 ? 94.144  97.356  121.569 1.00 106.19 ?  477 MET A C   1 
ATOM 3535 O O   . MET A 1 477 ? 93.167  96.640  121.748 1.00 108.53 ?  477 MET A O   1 
ATOM 3536 C CB  . MET A 1 477 ? 95.001  96.353  119.437 1.00 103.03 ?  477 MET A CB  1 
ATOM 3537 C CG  . MET A 1 477 ? 95.064  96.451  117.920 1.00 112.91 ?  477 MET A CG  1 
ATOM 3538 S SD  . MET A 1 477 ? 96.138  95.244  117.116 1.00 113.23 ?  477 MET A SD  1 
ATOM 3539 C CE  . MET A 1 477 ? 95.754  93.729  117.984 1.00 108.34 ?  477 MET A CE  1 
ATOM 3540 N N   . THR A 1 478 ? 94.809  97.912  122.581 1.00 111.92 ?  478 THR A N   1 
ATOM 3541 C CA  . THR A 1 478 ? 94.422  97.724  123.984 1.00 116.66 ?  478 THR A CA  1 
ATOM 3542 C C   . THR A 1 478 ? 93.381  98.743  124.416 1.00 112.45 ?  478 THR A C   1 
ATOM 3543 O O   . THR A 1 478 ? 93.002  98.782  125.576 1.00 110.78 ?  478 THR A O   1 
ATOM 3544 C CB  . THR A 1 478 ? 95.613  97.813  124.958 1.00 113.15 ?  478 THR A CB  1 
ATOM 3545 O OG1 . THR A 1 478 ? 96.094  99.162  125.036 1.00 109.60 ?  478 THR A OG1 1 
ATOM 3546 C CG2 . THR A 1 478 ? 96.745  96.844  124.578 1.00 108.94 ?  478 THR A CG2 1 
ATOM 3547 N N   . ALA A 1 479 ? 92.916  99.573  123.494 1.00 117.48 ?  479 ALA A N   1 
ATOM 3548 C CA  . ALA A 1 479 ? 91.885  100.556 123.799 1.00 119.68 ?  479 ALA A CA  1 
ATOM 3549 C C   . ALA A 1 479 ? 90.644  99.845  124.269 1.00 121.52 ?  479 ALA A C   1 
ATOM 3550 O O   . ALA A 1 479 ? 89.897  100.374 125.081 1.00 123.44 ?  479 ALA A O   1 
ATOM 3551 C CB  . ALA A 1 479 ? 91.562  101.393 122.583 1.00 121.96 ?  479 ALA A CB  1 
ATOM 3552 N N   . GLU A 1 480 ? 90.390  98.664  123.728 1.00 129.43 ?  480 GLU A N   1 
ATOM 3553 C CA  . GLU A 1 480 ? 89.221  97.891  124.127 1.00 129.66 ?  480 GLU A CA  1 
ATOM 3554 C C   . GLU A 1 480 ? 89.288  97.570  125.604 1.00 129.76 ?  480 GLU A C   1 
ATOM 3555 O O   . GLU A 1 480 ? 88.277  97.638  126.298 1.00 131.88 ?  480 GLU A O   1 
ATOM 3556 C CB  . GLU A 1 480 ? 89.147  96.573  123.355 1.00 129.28 ?  480 GLU A CB  1 
ATOM 3557 C CG  . GLU A 1 480 ? 88.811  96.711  121.885 1.00 130.06 ?  480 GLU A CG  1 
ATOM 3558 C CD  . GLU A 1 480 ? 90.034  96.748  120.988 1.00 133.87 ?  480 GLU A CD  1 
ATOM 3559 O OE1 . GLU A 1 480 ? 90.515  97.859  120.683 1.00 134.02 ?  480 GLU A OE1 1 
ATOM 3560 O OE2 . GLU A 1 480 ? 90.504  95.669  120.575 1.00 133.67 -1 480 GLU A OE2 1 
ATOM 3561 N N   . LEU A 1 481 ? 90.473  97.217  126.089 1.00 131.36 ?  481 LEU A N   1 
ATOM 3562 C CA  . LEU A 1 481 ? 90.637  96.906  127.501 1.00 133.92 ?  481 LEU A CA  1 
ATOM 3563 C C   . LEU A 1 481 ? 90.343  98.138  128.319 1.00 129.96 ?  481 LEU A C   1 
ATOM 3564 O O   . LEU A 1 481 ? 89.596  98.051  129.286 1.00 130.06 ?  481 LEU A O   1 
ATOM 3565 C CB  . LEU A 1 481 ? 92.062  96.431  127.808 1.00 135.03 ?  481 LEU A CB  1 
ATOM 3566 C CG  . LEU A 1 481 ? 92.743  95.369  126.929 1.00 133.41 ?  481 LEU A CG  1 
ATOM 3567 C CD1 . LEU A 1 481 ? 94.070  94.948  127.541 1.00 128.06 ?  481 LEU A CD1 1 
ATOM 3568 C CD2 . LEU A 1 481 ? 91.844  94.163  126.696 1.00 131.42 ?  481 LEU A CD2 1 
ATOM 3569 N N   . TYR A 1 482 ? 90.880  99.287  127.911 1.00 135.25 ?  482 TYR A N   1 
ATOM 3570 C CA  . TYR A 1 482 ? 90.651  100.550 128.612 1.00 136.50 ?  482 TYR A CA  1 
ATOM 3571 C C   . TYR A 1 482 ? 90.868  101.706 127.616 1.00 136.88 ?  482 TYR A C   1 
ATOM 3572 O O   . TYR A 1 482 ? 91.890  101.727 126.949 1.00 137.11 ?  482 TYR A O   1 
ATOM 3573 C CB  . TYR A 1 482 ? 91.605  100.744 129.782 1.00 136.17 ?  482 TYR A CB  1 
ATOM 3574 C CG  . TYR A 1 482 ? 91.507  99.705  130.870 1.00 140.21 ?  482 TYR A CG  1 
ATOM 3575 C CD1 . TYR A 1 482 ? 90.627  99.862  131.930 1.00 138.45 ?  482 TYR A CD1 1 
ATOM 3576 C CD2 . TYR A 1 482 ? 92.294  98.562  130.835 1.00 138.00 ?  482 TYR A CD2 1 
ATOM 3577 C CE1 . TYR A 1 482 ? 90.533  98.909  132.924 1.00 139.53 ?  482 TYR A CE1 1 
ATOM 3578 C CE2 . TYR A 1 482 ? 92.204  97.603  131.821 1.00 137.54 ?  482 TYR A CE2 1 
ATOM 3579 C CZ  . TYR A 1 482 ? 91.323  97.784  132.865 1.00 139.01 ?  482 TYR A CZ  1 
ATOM 3580 O OH  . TYR A 1 482 ? 91.228  96.836  133.855 1.00 134.80 ?  482 TYR A OH  1 
ATOM 3581 N N   . PRO A 1 483 ? 89.925  102.670 127.508 1.00 130.37 ?  483 PRO A N   1 
ATOM 3582 C CA  . PRO A 1 483 ? 90.059  103.754 126.520 1.00 128.14 ?  483 PRO A CA  1 
ATOM 3583 C C   . PRO A 1 483 ? 91.339  104.561 126.654 1.00 127.78 ?  483 PRO A C   1 
ATOM 3584 O O   . PRO A 1 483 ? 91.878  105.016 125.638 1.00 129.63 ?  483 PRO A O   1 
ATOM 3585 C CB  . PRO A 1 483 ? 88.818  104.619 126.784 1.00 125.95 ?  483 PRO A CB  1 
ATOM 3586 C CG  . PRO A 1 483 ? 87.840  103.693 127.430 1.00 128.42 ?  483 PRO A CG  1 
ATOM 3587 C CD  . PRO A 1 483 ? 88.664  102.757 128.262 1.00 128.69 ?  483 PRO A CD  1 
ATOM 3588 N N   . SER A 1 484 ? 91.861  104.696 127.866 1.00 113.20 ?  484 SER A N   1 
ATOM 3589 C CA  . SER A 1 484 ? 93.056  105.495 128.059 1.00 114.52 ?  484 SER A CA  1 
ATOM 3590 C C   . SER A 1 484 ? 94.319  104.672 128.218 1.00 116.46 ?  484 SER A C   1 
ATOM 3591 O O   . SER A 1 484 ? 95.387  105.231 128.404 1.00 121.45 ?  484 SER A O   1 
ATOM 3592 C CB  . SER A 1 484 ? 92.889  106.443 129.235 1.00 113.36 ?  484 SER A CB  1 
ATOM 3593 O OG  . SER A 1 484 ? 92.031  107.517 128.896 1.00 113.53 ?  484 SER A OG  1 
ATOM 3594 N N   . MET A 1 485 ? 94.242  103.342 128.147 1.00 109.38 ?  485 MET A N   1 
ATOM 3595 C CA  . MET A 1 485 ? 95.457  102.526 128.219 1.00 107.38 ?  485 MET A CA  1 
ATOM 3596 C C   . MET A 1 485 ? 96.410  102.773 127.071 1.00 110.68 ?  485 MET A C   1 
ATOM 3597 O O   . MET A 1 485 ? 97.605  102.805 127.279 1.00 121.04 ?  485 MET A O   1 
ATOM 3598 C CB  . MET A 1 485 ? 95.155  101.033 128.360 1.00 110.07 ?  485 MET A CB  1 
ATOM 3599 C CG  . MET A 1 485 ? 96.365  100.117 128.287 1.00 107.87 ?  485 MET A CG  1 
ATOM 3600 S SD  . MET A 1 485 ? 95.940  98.429  128.738 1.00 124.13 ?  485 MET A SD  1 
ATOM 3601 C CE  . MET A 1 485 ? 95.844  98.542  130.522 1.00 114.28 ?  485 MET A CE  1 
ATOM 3602 N N   . PRO A 1 486 ? 95.904  102.920 125.839 1.00 102.00 ?  486 PRO A N   1 
ATOM 3603 C CA  . PRO A 1 486 ? 96.888  103.242 124.808 1.00 102.83 ?  486 PRO A CA  1 
ATOM 3604 C C   . PRO A 1 486 ? 97.697  104.498 125.124 1.00 107.34 ?  486 PRO A C   1 
ATOM 3605 O O   . PRO A 1 486 ? 98.898  104.439 124.928 1.00 112.75 ?  486 PRO A O   1 
ATOM 3606 C CB  . PRO A 1 486 ? 96.030  103.466 123.585 1.00 101.13 ?  486 PRO A CB  1 
ATOM 3607 C CG  . PRO A 1 486 ? 94.909  102.521 123.763 1.00 110.95 ?  486 PRO A CG  1 
ATOM 3608 C CD  . PRO A 1 486 ? 94.622  102.508 125.234 1.00 105.48 ?  486 PRO A CD  1 
ATOM 3609 N N   . LEU A 1 487 ? 97.081  105.584 125.600 1.00 96.82  ?  487 LEU A N   1 
ATOM 3610 C CA  . LEU A 1 487 ? 97.793  106.838 125.842 1.00 92.57  ?  487 LEU A CA  1 
ATOM 3611 C C   . LEU A 1 487 ? 98.709  106.735 127.055 1.00 93.67  ?  487 LEU A C   1 
ATOM 3612 O O   . LEU A 1 487 ? 99.799  107.281 127.036 1.00 103.95 ?  487 LEU A O   1 
ATOM 3613 C CB  . LEU A 1 487 ? 96.844  108.027 126.021 1.00 95.52  ?  487 LEU A CB  1 
ATOM 3614 C CG  . LEU A 1 487 ? 96.170  108.616 124.777 1.00 96.33  ?  487 LEU A CG  1 
ATOM 3615 C CD1 . LEU A 1 487 ? 95.034  109.547 125.172 1.00 98.38  ?  487 LEU A CD1 1 
ATOM 3616 C CD2 . LEU A 1 487 ? 97.161  109.365 123.894 1.00 93.41  ?  487 LEU A CD2 1 
ATOM 3617 N N   . PHE A 1 488 ? 98.283  106.040 128.103 1.00 84.66  ?  488 PHE A N   1 
ATOM 3618 C CA  . PHE A 1 488 ? 99.111  105.930 129.287 1.00 82.61  ?  488 PHE A CA  1 
ATOM 3619 C C   . PHE A 1 488 ? 100.408 105.209 128.975 1.00 91.44  ?  488 PHE A C   1 
ATOM 3620 O O   . PHE A 1 488 ? 101.404 105.487 129.618 1.00 100.07 ?  488 PHE A O   1 
ATOM 3621 C CB  . PHE A 1 488 ? 98.407  105.230 130.449 1.00 84.43  ?  488 PHE A CB  1 
ATOM 3622 C CG  . PHE A 1 488 ? 97.223  105.976 131.016 1.00 88.89  ?  488 PHE A CG  1 
ATOM 3623 C CD1 . PHE A 1 488 ? 96.089  105.279 131.390 1.00 96.53  ?  488 PHE A CD1 1 
ATOM 3624 C CD2 . PHE A 1 488 ? 97.245  107.352 131.208 1.00 91.55  ?  488 PHE A CD2 1 
ATOM 3625 C CE1 . PHE A 1 488 ? 94.999  105.933 131.923 1.00 99.61  ?  488 PHE A CE1 1 
ATOM 3626 C CE2 . PHE A 1 488 ? 96.156  108.007 131.738 1.00 98.89  ?  488 PHE A CE2 1 
ATOM 3627 C CZ  . PHE A 1 488 ? 95.031  107.299 132.096 1.00 102.49 ?  488 PHE A CZ  1 
ATOM 3628 N N   . ILE A 1 489 ? 100.412 104.278 128.025 1.00 89.18  ?  489 ILE A N   1 
ATOM 3629 C CA  . ILE A 1 489 ? 101.642 103.611 127.615 1.00 88.94  ?  489 ILE A CA  1 
ATOM 3630 C C   . ILE A 1 489 ? 102.458 104.537 126.724 1.00 91.86  ?  489 ILE A C   1 
ATOM 3631 O O   . ILE A 1 489 ? 103.661 104.639 126.888 1.00 101.44 ?  489 ILE A O   1 
ATOM 3632 C CB  . ILE A 1 489 ? 101.371 102.273 126.910 1.00 90.15  ?  489 ILE A CB  1 
ATOM 3633 C CG1 . ILE A 1 489 ? 100.554 101.357 127.816 1.00 91.74  ?  489 ILE A CG1 1 
ATOM 3634 C CG2 . ILE A 1 489 ? 102.667 101.581 126.531 1.00 82.46  ?  489 ILE A CG2 1 
ATOM 3635 C CD1 . ILE A 1 489 ? 100.181 100.041 127.174 1.00 94.31  ?  489 ILE A CD1 1 
ATOM 3636 N N   . TYR A 1 490 ? 101.833 105.137 125.714 1.00 94.02  ?  490 TYR A N   1 
ATOM 3637 C CA  . TYR A 1 490 ? 102.558 105.996 124.778 1.00 94.30  ?  490 TYR A CA  1 
ATOM 3638 C C   . TYR A 1 490 ? 103.157 107.147 125.525 1.00 92.36  ?  490 TYR A C   1 
ATOM 3639 O O   . TYR A 1 490 ? 103.920 107.907 124.962 1.00 103.06 ?  490 TYR A O   1 
ATOM 3640 C CB  . TYR A 1 490 ? 101.651 106.593 123.706 1.00 92.96  ?  490 TYR A CB  1 
ATOM 3641 C CG  . TYR A 1 490 ? 101.043 105.644 122.722 1.00 92.77  ?  490 TYR A CG  1 
ATOM 3642 C CD1 . TYR A 1 490 ? 101.770 104.601 122.188 1.00 93.75  ?  490 TYR A CD1 1 
ATOM 3643 C CD2 . TYR A 1 490 ? 99.743  105.827 122.290 1.00 94.22  ?  490 TYR A CD2 1 
ATOM 3644 C CE1 . TYR A 1 490 ? 101.206 103.741 121.274 1.00 93.74  ?  490 TYR A CE1 1 
ATOM 3645 C CE2 . TYR A 1 490 ? 99.169  104.974 121.382 1.00 94.45  ?  490 TYR A CE2 1 
ATOM 3646 C CZ  . TYR A 1 490 ? 99.907  103.936 120.879 1.00 93.76  ?  490 TYR A CZ  1 
ATOM 3647 O OH  . TYR A 1 490 ? 99.334  103.097 119.968 1.00 101.31 ?  490 TYR A OH  1 
ATOM 3648 N N   . GLY A 1 491 ? 102.815 107.291 126.791 1.00 88.22  ?  491 GLY A N   1 
ATOM 3649 C CA  . GLY A 1 491 ? 103.341 108.374 127.589 1.00 89.82  ?  491 GLY A CA  1 
ATOM 3650 C C   . GLY A 1 491 ? 104.377 107.894 128.563 1.00 91.56  ?  491 GLY A C   1 
ATOM 3651 O O   . GLY A 1 491 ? 105.398 108.538 128.741 1.00 100.09 ?  491 GLY A O   1 
ATOM 3652 N N   . ALA A 1 492 ? 104.123 106.769 129.205 1.00 77.65  ?  492 ALA A N   1 
ATOM 3653 C CA  . ALA A 1 492 ? 105.079 106.202 130.132 1.00 80.75  ?  492 ALA A CA  1 
ATOM 3654 C C   . ALA A 1 492 ? 106.381 105.776 129.478 1.00 89.08  ?  492 ALA A C   1 
ATOM 3655 O O   . ALA A 1 492 ? 107.439 105.921 130.072 1.00 100.78 ?  492 ALA A O   1 
ATOM 3656 C CB  . ALA A 1 492 ? 104.470 105.051 130.881 1.00 80.38  ?  492 ALA A CB  1 
ATOM 3657 N N   . VAL A 1 493 ? 106.317 105.234 128.269 1.00 88.26  ?  493 VAL A N   1 
ATOM 3658 C CA  . VAL A 1 493 ? 107.537 104.839 127.572 1.00 89.66  ?  493 VAL A CA  1 
ATOM 3659 C C   . VAL A 1 493 ? 108.493 106.009 127.292 1.00 94.16  ?  493 VAL A C   1 
ATOM 3660 O O   . VAL A 1 493 ? 109.684 105.884 127.548 1.00 92.82  ?  493 VAL A O   1 
ATOM 3661 C CB  . VAL A 1 493 ? 107.243 103.982 126.322 1.00 87.67  ?  493 VAL A CB  1 
ATOM 3662 C CG1 . VAL A 1 493 ? 108.518 103.656 125.565 1.00 86.58  ?  493 VAL A CG1 1 
ATOM 3663 C CG2 . VAL A 1 493 ? 106.535 102.703 126.726 1.00 89.67  ?  493 VAL A CG2 1 
ATOM 3664 N N   . PRO A 1 494 ? 107.997 107.173 126.785 1.00 89.94  ?  494 PRO A N   1 
ATOM 3665 C CA  . PRO A 1 494 ? 108.949 108.290 126.666 1.00 86.46  ?  494 PRO A CA  1 
ATOM 3666 C C   . PRO A 1 494 ? 109.462 108.829 127.999 1.00 88.72  ?  494 PRO A C   1 
ATOM 3667 O O   . PRO A 1 494 ? 110.602 109.261 128.045 1.00 96.43  ?  494 PRO A O   1 
ATOM 3668 C CB  . PRO A 1 494 ? 108.137 109.369 125.985 1.00 82.49  ?  494 PRO A CB  1 
ATOM 3669 C CG  . PRO A 1 494 ? 107.208 108.630 125.144 1.00 86.49  ?  494 PRO A CG  1 
ATOM 3670 C CD  . PRO A 1 494 ? 106.804 107.449 125.958 1.00 86.36  ?  494 PRO A CD  1 
ATOM 3671 N N   . VAL A 1 495 ? 108.663 108.818 129.056 1.00 79.35  ?  495 VAL A N   1 
ATOM 3672 C CA  . VAL A 1 495 ? 109.147 109.248 130.354 1.00 87.89  ?  495 VAL A CA  1 
ATOM 3673 C C   . VAL A 1 495 ? 110.271 108.327 130.809 1.00 96.25  ?  495 VAL A C   1 
ATOM 3674 O O   . VAL A 1 495 ? 111.252 108.795 131.371 1.00 101.92 ?  495 VAL A O   1 
ATOM 3675 C CB  . VAL A 1 495 ? 108.017 109.344 131.384 1.00 85.70  ?  495 VAL A CB  1 
ATOM 3676 C CG1 . VAL A 1 495 ? 108.559 109.598 132.780 1.00 90.90  ?  495 VAL A CG1 1 
ATOM 3677 C CG2 . VAL A 1 495 ? 107.040 110.435 130.992 1.00 77.33  ?  495 VAL A CG2 1 
ATOM 3678 N N   . ALA A 1 496 ? 110.178 107.029 130.547 1.00 82.88  ?  496 ALA A N   1 
ATOM 3679 C CA  . ALA A 1 496 ? 111.252 106.099 130.911 1.00 80.88  ?  496 ALA A CA  1 
ATOM 3680 C C   . ALA A 1 496 ? 112.481 106.281 130.064 1.00 87.71  ?  496 ALA A C   1 
ATOM 3681 O O   . ALA A 1 496 ? 113.585 106.152 130.562 1.00 91.15  ?  496 ALA A O   1 
ATOM 3682 C CB  . ALA A 1 496 ? 110.776 104.676 130.809 1.00 86.41  ?  496 ALA A CB  1 
ATOM 3683 N N   . ALA A 1 497 ? 112.310 106.557 128.780 1.00 90.78  ?  497 ALA A N   1 
ATOM 3684 C CA  . ALA A 1 497 ? 113.442 106.839 127.901 1.00 93.19  ?  497 ALA A CA  1 
ATOM 3685 C C   . ALA A 1 497 ? 114.183 108.094 128.316 1.00 87.60  ?  497 ALA A C   1 
ATOM 3686 O O   . ALA A 1 497 ? 115.393 108.154 128.227 1.00 99.24  ?  497 ALA A O   1 
ATOM 3687 C CB  . ALA A 1 497 ? 112.986 106.967 126.476 1.00 90.24  ?  497 ALA A CB  1 
ATOM 3688 N N   . SER A 1 498 ? 113.469 109.107 128.768 1.00 71.16  ?  498 SER A N   1 
ATOM 3689 C CA  . SER A 1 498 ? 114.117 110.307 129.232 1.00 79.27  ?  498 SER A CA  1 
ATOM 3690 C C   . SER A 1 498 ? 115.027 109.989 130.397 1.00 84.08  ?  498 SER A C   1 
ATOM 3691 O O   . SER A 1 498 ? 116.086 110.571 130.526 1.00 92.20  ?  498 SER A O   1 
ATOM 3692 C CB  . SER A 1 498 ? 113.089 111.323 129.675 1.00 88.11  ?  498 SER A CB  1 
ATOM 3693 O OG  . SER A 1 498 ? 112.681 111.103 131.008 1.00 89.13  ?  498 SER A OG  1 
ATOM 3694 N N   . ALA A 1 499 ? 114.616 109.089 131.272 1.00 79.38  ?  499 ALA A N   1 
ATOM 3695 C CA  . ALA A 1 499 ? 115.457 108.702 132.385 1.00 82.51  ?  499 ALA A CA  1 
ATOM 3696 C C   . ALA A 1 499 ? 116.665 107.956 131.892 1.00 89.39  ?  499 ALA A C   1 
ATOM 3697 O O   . ALA A 1 499 ? 117.758 108.171 132.388 1.00 92.88  ?  499 ALA A O   1 
ATOM 3698 C CB  . ALA A 1 499 ? 114.681 107.849 133.356 1.00 92.58  ?  499 ALA A CB  1 
ATOM 3699 N N   . VAL A 1 500 ? 116.546 107.184 130.812 1.00 102.24 ?  500 VAL A N   1 
ATOM 3700 C CA  . VAL A 1 500 ? 117.712 106.492 130.203 1.00 99.86  ?  500 VAL A CA  1 
ATOM 3701 C C   . VAL A 1 500 ? 118.762 107.454 129.627 1.00 96.64  ?  500 VAL A C   1 
ATOM 3702 O O   . VAL A 1 500 ? 119.939 107.124 129.563 1.00 96.41  ?  500 VAL A O   1 
ATOM 3703 C CB  . VAL A 1 500 ? 117.274 105.494 129.106 1.00 89.45  ?  500 VAL A CB  1 
ATOM 3704 C CG1 . VAL A 1 500 ? 118.450 104.736 128.521 1.00 90.16  ?  500 VAL A CG1 1 
ATOM 3705 C CG2 . VAL A 1 500 ? 116.274 104.505 129.672 1.00 91.67  ?  500 VAL A CG2 1 
ATOM 3706 N N   . THR A 1 501 ? 118.377 108.651 129.186 1.00 95.95  ?  501 THR A N   1 
ATOM 3707 C CA  . THR A 1 501 ? 119.347 109.559 128.554 1.00 90.12  ?  501 THR A CA  1 
ATOM 3708 C C   . THR A 1 501 ? 120.367 110.030 129.563 1.00 89.74  ?  501 THR A C   1 
ATOM 3709 O O   . THR A 1 501 ? 121.436 110.475 129.185 1.00 98.47  ?  501 THR A O   1 
ATOM 3710 C CB  . THR A 1 501 ? 118.745 110.849 127.996 1.00 91.57  ?  501 THR A CB  1 
ATOM 3711 O OG1 . THR A 1 501 ? 118.285 111.632 129.082 1.00 103.29 ?  501 THR A OG1 1 
ATOM 3712 C CG2 . THR A 1 501 ? 117.601 110.629 127.025 1.00 93.60  ?  501 THR A CG2 1 
ATOM 3713 N N   . VAL A 1 502 ? 120.054 109.930 130.845 1.00 89.18  ?  502 VAL A N   1 
ATOM 3714 C CA  . VAL A 1 502 ? 120.961 110.381 131.894 1.00 97.08  ?  502 VAL A CA  1 
ATOM 3715 C C   . VAL A 1 502 ? 122.228 109.580 131.784 1.00 95.88  ?  502 VAL A C   1 
ATOM 3716 O O   . VAL A 1 502 ? 123.319 110.110 131.960 1.00 91.32  ?  502 VAL A O   1 
ATOM 3717 C CB  . VAL A 1 502 ? 120.346 110.213 133.301 1.00 94.04  ?  502 VAL A CB  1 
ATOM 3718 C CG1 . VAL A 1 502 ? 121.382 110.437 134.392 1.00 90.98  ?  502 VAL A CG1 1 
ATOM 3719 C CG2 . VAL A 1 502 ? 119.175 111.173 133.496 1.00 96.60  ?  502 VAL A CG2 1 
ATOM 3720 N N   . LEU A 1 503 ? 122.100 108.302 131.441 1.00 106.97 ?  503 LEU A N   1 
ATOM 3721 C CA  . LEU A 1 503 ? 123.257 107.419 131.356 1.00 109.99 ?  503 LEU A CA  1 
ATOM 3722 C C   . LEU A 1 503 ? 124.191 107.787 130.217 1.00 109.10 ?  503 LEU A C   1 
ATOM 3723 O O   . LEU A 1 503 ? 125.391 107.690 130.377 1.00 112.26 ?  503 LEU A O   1 
ATOM 3724 C CB  . LEU A 1 503 ? 122.804 105.965 131.191 1.00 101.82 ?  503 LEU A CB  1 
ATOM 3725 C CG  . LEU A 1 503 ? 121.930 105.319 132.271 1.00 101.52 ?  503 LEU A CG  1 
ATOM 3726 C CD1 . LEU A 1 503 ? 121.125 104.174 131.681 1.00 100.81 ?  503 LEU A CD1 1 
ATOM 3727 C CD2 . LEU A 1 503 ? 122.770 104.851 133.448 1.00 103.11 ?  503 LEU A CD2 1 
ATOM 3728 N N   . LEU A 1 504 ? 123.653 108.233 129.088 1.00 105.22 ?  504 LEU A N   1 
ATOM 3729 C CA  . LEU A 1 504 ? 124.467 108.559 127.916 1.00 102.30 ?  504 LEU A CA  1 
ATOM 3730 C C   . LEU A 1 504 ? 125.390 109.751 128.193 1.00 104.79 ?  504 LEU A C   1 
ATOM 3731 O O   . LEU A 1 504 ? 125.059 110.574 129.025 1.00 105.27 ?  504 LEU A O   1 
ATOM 3732 C CB  . LEU A 1 504 ? 123.581 108.856 126.707 1.00 101.34 ?  504 LEU A CB  1 
ATOM 3733 C CG  . LEU A 1 504 ? 122.772 107.739 126.055 1.00 99.09  ?  504 LEU A CG  1 
ATOM 3734 C CD1 . LEU A 1 504 ? 121.996 108.293 124.878 1.00 99.93  ?  504 LEU A CD1 1 
ATOM 3735 C CD2 . LEU A 1 504 ? 123.689 106.637 125.580 1.00 98.56  ?  504 LEU A CD2 1 
ATOM 3736 N N   . PRO A 1 505 ? 126.562 109.841 127.530 1.00 117.61 ?  505 PRO A N   1 
ATOM 3737 C CA  . PRO A 1 505 ? 127.538 110.917 127.762 1.00 118.57 ?  505 PRO A CA  1 
ATOM 3738 C C   . PRO A 1 505 ? 127.397 112.184 126.897 1.00 118.31 ?  505 PRO A C   1 
ATOM 3739 O O   . PRO A 1 505 ? 127.187 112.073 125.701 1.00 115.96 ?  505 PRO A O   1 
ATOM 3740 C CB  . PRO A 1 505 ? 128.848 110.231 127.411 1.00 118.53 ?  505 PRO A CB  1 
ATOM 3741 C CG  . PRO A 1 505 ? 128.491 109.277 126.322 1.00 118.18 ?  505 PRO A CG  1 
ATOM 3742 C CD  . PRO A 1 505 ? 127.012 108.981 126.429 1.00 114.04 ?  505 PRO A CD  1 
ATOM 3743 N N   . GLU A 1 506 ? 127.558 113.367 127.481 1.00 128.90 ?  506 GLU A N   1 
ATOM 3744 C CA  . GLU A 1 506 ? 127.385 114.634 126.747 1.00 129.54 ?  506 GLU A CA  1 
ATOM 3745 C C   . GLU A 1 506 ? 128.357 114.803 125.583 1.00 131.17 ?  506 GLU A C   1 
ATOM 3746 O O   . GLU A 1 506 ? 129.551 114.602 125.797 1.00 133.92 ?  506 GLU A O   1 
ATOM 3747 C CB  . GLU A 1 506 ? 127.553 115.807 127.724 1.00 131.01 ?  506 GLU A CB  1 
ATOM 3748 C CG  . GLU A 1 506 ? 127.442 117.204 127.137 1.00 128.90 ?  506 GLU A CG  1 
ATOM 3749 C CD  . GLU A 1 506 ? 126.091 117.473 126.520 1.00 132.79 ?  506 GLU A CD  1 
ATOM 3750 O OE1 . GLU A 1 506 ? 125.191 117.916 127.254 1.00 131.69 ?  506 GLU A OE1 1 
ATOM 3751 O OE2 . GLU A 1 506 ? 125.933 117.240 125.309 1.00 133.44 -1 506 GLU A OE2 1 
ATOM 3752 N N   . THR A 1 507 ? 127.872 115.180 124.385 1.00 131.43 ?  507 THR A N   1 
ATOM 3753 C CA  . THR A 1 507 ? 128.713 115.327 123.205 1.00 133.14 ?  507 THR A CA  1 
ATOM 3754 C C   . THR A 1 507 ? 128.981 116.754 122.734 1.00 133.54 ?  507 THR A C   1 
ATOM 3755 O O   . THR A 1 507 ? 129.647 116.946 121.722 1.00 134.07 ?  507 THR A O   1 
ATOM 3756 C CB  . THR A 1 507 ? 128.174 114.501 122.032 1.00 132.50 ?  507 THR A CB  1 
ATOM 3757 O OG1 . THR A 1 507 ? 126.773 114.746 121.884 1.00 135.54 ?  507 THR A OG1 1 
ATOM 3758 C CG2 . THR A 1 507 ? 128.395 113.027 122.284 1.00 130.83 ?  507 THR A CG2 1 
ATOM 3759 N N   . LEU A 1 508 ? 128.475 117.757 123.440 1.00 137.48 ?  508 LEU A N   1 
ATOM 3760 C CA  . LEU A 1 508 ? 128.650 119.137 122.980 1.00 138.74 ?  508 LEU A CA  1 
ATOM 3761 C C   . LEU A 1 508 ? 130.061 119.644 123.215 1.00 142.17 ?  508 LEU A C   1 
ATOM 3762 O O   . LEU A 1 508 ? 130.533 119.679 124.352 1.00 140.45 ?  508 LEU A O   1 
ATOM 3763 C CB  . LEU A 1 508 ? 127.605 120.090 123.567 1.00 136.50 ?  508 LEU A CB  1 
ATOM 3764 C CG  . LEU A 1 508 ? 127.678 121.572 123.193 1.00 132.88 ?  508 LEU A CG  1 
ATOM 3765 C CD1 . LEU A 1 508 ? 127.574 121.776 121.692 1.00 134.78 ?  508 LEU A CD1 1 
ATOM 3766 C CD2 . LEU A 1 508 ? 126.607 122.373 123.911 1.00 135.09 ?  508 LEU A CD2 1 
ATOM 3767 N N   . GLY A 1 509 ? 130.738 120.036 122.149 1.00 149.16 ?  509 GLY A N   1 
ATOM 3768 C CA  . GLY A 1 509 ? 132.099 120.519 122.215 1.00 145.58 ?  509 GLY A CA  1 
ATOM 3769 C C   . GLY A 1 509 ? 133.166 119.450 122.279 1.00 145.89 ?  509 GLY A C   1 
ATOM 3770 O O   . GLY A 1 509 ? 134.350 119.790 122.396 1.00 145.18 ?  509 GLY A O   1 
ATOM 3771 N N   . GLN A 1 510 ? 132.774 118.187 122.180 1.00 147.51 ?  510 GLN A N   1 
ATOM 3772 C CA  . GLN A 1 510 ? 133.734 117.097 122.204 1.00 147.15 ?  510 GLN A CA  1 
ATOM 3773 C C   . GLN A 1 510 ? 133.946 116.522 120.809 1.00 149.26 ?  510 GLN A C   1 
ATOM 3774 O O   . GLN A 1 510 ? 132.985 116.323 120.067 1.00 145.65 ?  510 GLN A O   1 
ATOM 3775 C CB  . GLN A 1 510 ? 133.267 116.012 123.166 1.00 143.20 ?  510 GLN A CB  1 
ATOM 3776 C CG  . GLN A 1 510 ? 133.143 116.470 124.607 1.00 142.43 ?  510 GLN A CG  1 
ATOM 3777 C CD  . GLN A 1 510 ? 132.757 115.342 125.539 1.00 147.84 ?  510 GLN A CD  1 
ATOM 3778 O OE1 . GLN A 1 510 ? 132.601 114.197 125.115 1.00 149.62 ?  510 GLN A OE1 1 
ATOM 3779 N NE2 . GLN A 1 510 ? 132.596 115.659 126.818 1.00 148.01 ?  510 GLN A NE2 1 
ATOM 3780 N N   . PRO A 1 511 ? 135.206 116.191 120.444 1.00 154.08 ?  511 PRO A N   1 
ATOM 3781 C CA  . PRO A 1 511 ? 135.385 115.688 119.082 1.00 150.36 ?  511 PRO A CA  1 
ATOM 3782 C C   . PRO A 1 511 ? 134.848 114.273 118.940 1.00 150.42 ?  511 PRO A C   1 
ATOM 3783 O O   . PRO A 1 511 ? 134.789 113.560 119.937 1.00 152.46 ?  511 PRO A O   1 
ATOM 3784 C CB  . PRO A 1 511 ? 136.897 115.690 118.915 1.00 148.65 ?  511 PRO A CB  1 
ATOM 3785 C CG  . PRO A 1 511 ? 137.421 115.443 120.282 1.00 148.24 ?  511 PRO A CG  1 
ATOM 3786 C CD  . PRO A 1 511 ? 136.466 116.127 121.214 1.00 149.32 ?  511 PRO A CD  1 
ATOM 3787 N N   . LEU A 1 512 ? 134.497 113.852 117.730 1.00 135.89 ?  512 LEU A N   1 
ATOM 3788 C CA  . LEU A 1 512 ? 133.889 112.534 117.536 1.00 138.56 ?  512 LEU A CA  1 
ATOM 3789 C C   . LEU A 1 512 ? 134.876 111.411 117.884 1.00 139.12 ?  512 LEU A C   1 
ATOM 3790 O O   . LEU A 1 512 ? 136.058 111.527 117.567 1.00 136.90 ?  512 LEU A O   1 
ATOM 3791 C CB  . LEU A 1 512 ? 133.416 112.368 116.093 1.00 137.57 ?  512 LEU A CB  1 
ATOM 3792 C CG  . LEU A 1 512 ? 132.464 113.392 115.451 1.00 138.54 ?  512 LEU A CG  1 
ATOM 3793 C CD1 . LEU A 1 512 ? 132.422 113.218 113.941 1.00 135.84 ?  512 LEU A CD1 1 
ATOM 3794 C CD2 . LEU A 1 512 ? 131.066 113.273 116.027 1.00 136.26 ?  512 LEU A CD2 1 
ATOM 3795 N N   . PRO A 1 513 ? 134.404 110.314 118.523 1.00 136.68 ?  513 PRO A N   1 
ATOM 3796 C CA  . PRO A 1 513 ? 135.381 109.291 118.919 1.00 135.48 ?  513 PRO A CA  1 
ATOM 3797 C C   . PRO A 1 513 ? 135.831 108.472 117.716 1.00 137.68 ?  513 PRO A C   1 
ATOM 3798 O O   . PRO A 1 513 ? 135.035 108.347 116.804 1.00 139.22 ?  513 PRO A O   1 
ATOM 3799 C CB  . PRO A 1 513 ? 134.618 108.425 119.922 1.00 132.50 ?  513 PRO A CB  1 
ATOM 3800 C CG  . PRO A 1 513 ? 133.177 108.671 119.672 1.00 131.67 ?  513 PRO A CG  1 
ATOM 3801 C CD  . PRO A 1 513 ? 133.025 109.936 118.879 1.00 132.93 ?  513 PRO A CD  1 
ATOM 3802 N N   . ASP A 1 514 ? 137.070 107.979 117.683 1.00 146.05 ?  514 ASP A N   1 
ATOM 3803 C CA  . ASP A 1 514 ? 137.536 107.108 116.587 1.00 145.44 ?  514 ASP A CA  1 
ATOM 3804 C C   . ASP A 1 514 ? 137.691 105.654 117.031 1.00 145.66 ?  514 ASP A C   1 
ATOM 3805 O O   . ASP A 1 514 ? 137.608 104.767 116.180 1.00 143.28 ?  514 ASP A O   1 
ATOM 3806 C CB  . ASP A 1 514 ? 138.875 107.603 116.039 1.00 144.46 ?  514 ASP A CB  1 
ATOM 3807 C CG  . ASP A 1 514 ? 138.769 108.947 115.331 1.00 145.25 ?  514 ASP A CG  1 
ATOM 3808 O OD1 . ASP A 1 514 ? 139.823 109.475 114.922 1.00 143.85 ?  514 ASP A OD1 1 
ATOM 3809 O OD2 . ASP A 1 514 ? 137.649 109.478 115.173 1.00 144.89 -1 514 ASP A OD2 1 
ATOM 3810 N N   . THR A 1 515 ? 137.908 105.409 118.328 1.00 150.02 ?  515 THR A N   1 
ATOM 3811 C CA  . THR A 1 515 ? 138.096 104.066 118.861 1.00 150.79 ?  515 THR A CA  1 
ATOM 3812 C C   . THR A 1 515 ? 137.243 103.808 120.074 1.00 149.68 ?  515 THR A C   1 
ATOM 3813 O O   . THR A 1 515 ? 136.642 104.726 120.616 1.00 148.56 ?  515 THR A O   1 
ATOM 3814 C CB  . THR A 1 515 ? 139.555 103.813 119.284 1.00 151.47 ?  515 THR A CB  1 
ATOM 3815 O OG1 . THR A 1 515 ? 139.947 104.787 120.259 1.00 148.87 ?  515 THR A OG1 1 
ATOM 3816 C CG2 . THR A 1 515 ? 140.499 103.883 118.092 1.00 148.22 ?  515 THR A CG2 1 
ATOM 3817 N N   . VAL A 1 516 ? 137.179 102.557 120.507 1.00 150.78 ?  516 VAL A N   1 
ATOM 3818 C CA  . VAL A 1 516 ? 136.459 102.241 121.727 1.00 151.72 ?  516 VAL A CA  1 
ATOM 3819 C C   . VAL A 1 516 ? 137.166 102.941 122.879 1.00 153.01 ?  516 VAL A C   1 
ATOM 3820 O O   . VAL A 1 516 ? 136.520 103.463 123.780 1.00 154.42 ?  516 VAL A O   1 
ATOM 3821 C CB  . VAL A 1 516 ? 136.395 100.727 121.969 1.00 149.07 ?  516 VAL A CB  1 
ATOM 3822 C CG1 . VAL A 1 516 ? 135.590 100.411 123.217 1.00 149.25 ?  516 VAL A CG1 1 
ATOM 3823 C CG2 . VAL A 1 516 ? 135.783 100.036 120.762 1.00 148.76 ?  516 VAL A CG2 1 
ATOM 3824 N N   . GLN A 1 517 ? 138.495 102.960 122.851 1.00 155.24 ?  517 GLN A N   1 
ATOM 3825 C CA  . GLN A 1 517 ? 139.265 103.628 123.900 1.00 154.64 ?  517 GLN A CA  1 
ATOM 3826 C C   . GLN A 1 517 ? 138.742 105.021 124.210 1.00 154.88 ?  517 GLN A C   1 
ATOM 3827 O O   . GLN A 1 517 ? 138.566 105.370 125.371 1.00 154.84 ?  517 GLN A O   1 
ATOM 3828 C CB  . GLN A 1 517 ? 140.738 103.708 123.505 1.00 152.65 ?  517 GLN A CB  1 
ATOM 3829 C CG  . GLN A 1 517 ? 141.652 104.214 124.608 1.00 154.99 ?  517 GLN A CG  1 
ATOM 3830 C CD  . GLN A 1 517 ? 141.764 103.244 125.768 1.00 157.01 ?  517 GLN A CD  1 
ATOM 3831 O OE1 . GLN A 1 517 ? 141.678 102.029 125.591 1.00 155.59 ?  517 GLN A OE1 1 
ATOM 3832 N NE2 . GLN A 1 517 ? 141.972 103.778 126.965 1.00 156.93 ?  517 GLN A NE2 1 
ATOM 3833 N N   . ASP A 1 518 ? 138.421 105.775 123.151 1.00 151.14 ?  518 ASP A N   1 
ATOM 3834 C CA  . ASP A 1 518 ? 137.888 107.124 123.312 1.00 150.80 ?  518 ASP A CA  1 
ATOM 3835 C C   . ASP A 1 518 ? 136.544 107.112 124.008 1.00 148.27 ?  518 ASP A C   1 
ATOM 3836 O O   . ASP A 1 518 ? 136.301 107.942 124.871 1.00 148.91 ?  518 ASP A O   1 
ATOM 3837 C CB  . ASP A 1 518 ? 137.735 107.831 121.953 1.00 149.89 ?  518 ASP A CB  1 
ATOM 3838 C CG  . ASP A 1 518 ? 139.063 108.083 121.255 1.00 150.12 ?  518 ASP A CG  1 
ATOM 3839 O OD1 . ASP A 1 518 ? 140.119 107.637 121.752 1.00 148.23 ?  518 ASP A OD1 1 
ATOM 3840 O OD2 . ASP A 1 518 ? 139.047 108.736 120.193 1.00 151.02 -1 518 ASP A OD2 1 
ATOM 3841 N N   . LEU A 1 519 ? 135.646 106.212 123.630 1.00 138.63 ?  519 LEU A N   1 
ATOM 3842 C CA  . LEU A 1 519 ? 134.397 106.133 124.361 1.00 141.55 ?  519 LEU A CA  1 
ATOM 3843 C C   . LEU A 1 519 ? 134.746 105.874 125.793 1.00 144.24 ?  519 LEU A C   1 
ATOM 3844 O O   . LEU A 1 519 ? 134.153 106.457 126.675 1.00 143.86 ?  519 LEU A O   1 
ATOM 3845 C CB  . LEU A 1 519 ? 133.525 104.979 123.934 1.00 139.75 ?  519 LEU A CB  1 
ATOM 3846 C CG  . LEU A 1 519 ? 132.871 104.925 122.577 1.00 140.41 ?  519 LEU A CG  1 
ATOM 3847 C CD1 . LEU A 1 519 ? 131.601 104.116 122.714 1.00 141.93 ?  519 LEU A CD1 1 
ATOM 3848 C CD2 . LEU A 1 519 ? 132.581 106.302 122.013 1.00 140.19 ?  519 LEU A CD2 1 
ATOM 3849 N N   . GLU A 1 520 ? 135.689 104.972 126.034 1.00 152.69 ?  520 GLU A N   1 
ATOM 3850 C CA  . GLU A 1 520 ? 136.015 104.602 127.413 1.00 151.83 ?  520 GLU A CA  1 
ATOM 3851 C C   . GLU A 1 520 ? 136.596 105.761 128.205 1.00 152.96 ?  520 GLU A C   1 
ATOM 3852 O O   . GLU A 1 520 ? 136.290 105.915 129.384 1.00 155.27 ?  520 GLU A O   1 
ATOM 3853 C CB  . GLU A 1 520 ? 136.978 103.409 127.474 1.00 150.54 ?  520 GLU A CB  1 
ATOM 3854 C CG  . GLU A 1 520 ? 136.381 102.092 127.008 1.00 151.48 ?  520 GLU A CG  1 
ATOM 3855 C CD  . GLU A 1 520 ? 137.379 100.949 126.993 1.00 153.51 ?  520 GLU A CD  1 
ATOM 3856 O OE1 . GLU A 1 520 ? 138.511 101.117 127.494 1.00 153.91 ?  520 GLU A OE1 1 
ATOM 3857 O OE2 . GLU A 1 520 ? 137.027 99.868  126.479 1.00 153.67 -1 520 GLU A OE2 1 
ATOM 3858 N N   . SER A 1 521 ? 137.447 106.559 127.575 1.00 150.04 ?  521 SER A N   1 
ATOM 3859 C CA  . SER A 1 521 ? 138.046 107.702 128.254 1.00 150.60 ?  521 SER A CA  1 
ATOM 3860 C C   . SER A 1 521 ? 136.940 108.673 128.668 1.00 151.35 ?  521 SER A C   1 
ATOM 3861 O O   . SER A 1 521 ? 137.050 109.318 129.710 1.00 147.23 ?  521 SER A O   1 
ATOM 3862 C CB  . SER A 1 521 ? 139.107 108.399 127.385 1.00 148.82 ?  521 SER A CB  1 
ATOM 3863 O OG  . SER A 1 521 ? 138.553 109.218 126.368 1.00 147.93 ?  521 SER A OG  1 
ATOM 3864 N N   . ARG A 1 522 ? 135.874 108.772 127.872 1.00 155.47 ?  522 ARG A N   1 
ATOM 3865 C CA  . ARG A 1 522 ? 134.731 109.628 128.229 1.00 154.80 ?  522 ARG A CA  1 
ATOM 3866 C C   . ARG A 1 522 ? 133.968 109.020 129.386 1.00 154.86 ?  522 ARG A C   1 
ATOM 3867 O O   . ARG A 1 522 ? 133.614 109.723 130.329 1.00 156.48 ?  522 ARG A O   1 
ATOM 3868 C CB  . ARG A 1 522 ? 133.741 109.783 127.065 1.00 152.94 ?  522 ARG A CB  1 
ATOM 3869 C CG  . ARG A 1 522 ? 134.185 110.638 125.885 1.00 149.50 ?  522 ARG A CG  1 
ATOM 3870 C CD  . ARG A 1 522 ? 133.226 110.425 124.717 1.00 152.90 ?  522 ARG A CD  1 
ATOM 3871 N NE  . ARG A 1 522 ? 133.293 111.460 123.682 1.00 154.39 ?  522 ARG A NE  1 
ATOM 3872 C CZ  . ARG A 1 522 ? 132.507 111.520 122.598 1.00 155.37 ?  522 ARG A CZ  1 
ATOM 3873 N NH1 . ARG A 1 522 ? 131.560 110.602 122.368 1.00 152.82 1  522 ARG A NH1 1 
ATOM 3874 N NH2 . ARG A 1 522 ? 132.662 112.518 121.726 1.00 154.55 ?  522 ARG A NH2 1 
# 
