data_9M2H
# 
_entry.id   9M2H 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9M2H         pdb_00009m2h 10.2210/pdb9m2h/pdb 
WWPDB D_1300057048 ?            ?                   
EMDB  EMD-63585    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-05-28 ? 
2 'EM metadata'     1 0 2025-05-28 ? 
3 FSC               1 0 2025-05-28 ? 
4 'Half map'        1 0 2025-05-28 1 
5 'Half map'        1 0 2025-05-28 2 
6 Image             1 0 2025-05-28 ? 
7 'Primary map'     1 0 2025-05-28 ? 
8 'Structure model' 2 0 2025-06-11 ? 
9 'EM metadata'     1 1 2025-06-11 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release'        ?                 ? 
2 2 'EM metadata'     repository 'Initial release'        ?                 ? 
3 3 FSC               repository 'Initial release'        ?                 ? 
4 4 'Half map'        repository 'Initial release'        ?                 ? 
5 5 'Half map'        repository 'Initial release'        ?                 ? 
6 6 Image             repository 'Initial release'        ?                 ? 
7 7 'Primary map'     repository 'Initial release'        ?                 ? 
8 8 'Structure model' author     'Coordinate replacement' 'Chirality error' ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 8 'Structure model' 'Atomic model'         
2 8 'Structure model' 'Data collection'      
3 8 'Structure model' 'Derived calculations' 
4 8 'Structure model' 'Structure summary'    
5 9 'EM metadata'     'Data processing'      
6 9 'EM metadata'     'Experimental summary' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 8 'Structure model' atom_site                
2 8 'Structure model' em_admin                 
3 8 'Structure model' em_software              
4 8 'Structure model' pdbx_contact_author      
5 8 'Structure model' pdbx_validate_rmsd_angle 
6 8 'Structure model' pdbx_validate_torsion    
7 8 'Structure model' struct_conf              
8 9 'EM metadata'     em_admin                 
9 9 'EM metadata'     em_software              
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 8 'Structure model' '_atom_site.Cartn_x'    
2 8 'Structure model' '_atom_site.Cartn_y'    
3 8 'Structure model' '_atom_site.Cartn_z'    
4 8 'Structure model' '_em_admin.last_update' 
5 9 'EM metadata'     '_em_admin.last_update' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9M2H 
_pdbx_database_status.recvd_initial_deposition_date   2025-02-27 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Structure of the auxin importer AUX1 in Arabidopsis thaliana in the CHPAA-bound state' 
_pdbx_database_related.db_id          EMD-63585 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              sunlf@ustc.edu.cn 
_pdbx_contact_author.name_first         Linfeng 
_pdbx_contact_author.name_last          Sun 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-9367-2444 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Sun, L.'  1 ? 
'Liu, X.'  2 ? 
'Wei, H.'  3 ? 
'Yang, Z.' 4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Structure of the auxin importer AUX1 in Arabidopsis thaliana in the CHPAA-bound state' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Sun, L.'  1 ? 
primary 'Liu, X.'  2 ? 
primary 'Wei, H.'  3 ? 
primary 'Yang, Z.' 4 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Auxin transporter protein 1'           54105.520 1 ? ? ? ? 
2 non-polymer syn '(3-CHLORO-4-HYDROXYPHENYL)ACETIC ACID' 186.592   1 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Auxin influx carrier protein 1,Polar auxin transport inhibitor-resistant protein 1' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MSEGVEAIVANDNGTDQVNGNRTGKDNEEHDGSTGSNLSNFLWHGGSVWDAWFSCASNQVAQVLLTLPYSFSQLGMLSGI
VLQIFYGLLGSWTAYLISVLYVEYRARKEKEGKSFKNHVIQWFEVLDGLLGSYWKALGLAFNCTFLLFGSVIQLIACASN
IYYINDHLDKRTWTYIFGACCATTVFIPSFHNYRIWSFLGLGMTTYTAWYLAIASIIHGQAEGVKHSGPTKLVLYFTGAT
NILYTFGGHAVTVEIMHAMWKPQKFKYIYLMATLYVFTLTIPSAAAVYWAFGDALLDHSNAFSLMPKNAWRDAAVILMLI
HQFITFGFACTPLYFVWEKVIGMHDTKSICLRALARLPVVIPIWFLAIIFPFFGPINSAVGALLVSFTVYIIPSLAHMLT
YRSASARQNAAEKPPFFMPSWTAMYVLNAFVVVWVLIVGFGFGGWASVTNFVRQVDTFGLFAKCYQCKPAAAAAHAPVSA
LHHRL
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MSEGVEAIVANDNGTDQVNGNRTGKDNEEHDGSTGSNLSNFLWHGGSVWDAWFSCASNQVAQVLLTLPYSFSQLGMLSGI
VLQIFYGLLGSWTAYLISVLYVEYRARKEKEGKSFKNHVIQWFEVLDGLLGSYWKALGLAFNCTFLLFGSVIQLIACASN
IYYINDHLDKRTWTYIFGACCATTVFIPSFHNYRIWSFLGLGMTTYTAWYLAIASIIHGQAEGVKHSGPTKLVLYFTGAT
NILYTFGGHAVTVEIMHAMWKPQKFKYIYLMATLYVFTLTIPSAAAVYWAFGDALLDHSNAFSLMPKNAWRDAAVILMLI
HQFITFGFACTPLYFVWEKVIGMHDTKSICLRALARLPVVIPIWFLAIIFPFFGPINSAVGALLVSFTVYIIPSLAHMLT
YRSASARQNAAEKPPFFMPSWTAMYVLNAFVVVWVLIVGFGFGGWASVTNFVRQVDTFGLFAKCYQCKPAAAAAHAPVSA
LHHRL
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        '(3-CHLORO-4-HYDROXYPHENYL)ACETIC ACID' 
_pdbx_entity_nonpoly.comp_id     3C4 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   SER n 
1 3   GLU n 
1 4   GLY n 
1 5   VAL n 
1 6   GLU n 
1 7   ALA n 
1 8   ILE n 
1 9   VAL n 
1 10  ALA n 
1 11  ASN n 
1 12  ASP n 
1 13  ASN n 
1 14  GLY n 
1 15  THR n 
1 16  ASP n 
1 17  GLN n 
1 18  VAL n 
1 19  ASN n 
1 20  GLY n 
1 21  ASN n 
1 22  ARG n 
1 23  THR n 
1 24  GLY n 
1 25  LYS n 
1 26  ASP n 
1 27  ASN n 
1 28  GLU n 
1 29  GLU n 
1 30  HIS n 
1 31  ASP n 
1 32  GLY n 
1 33  SER n 
1 34  THR n 
1 35  GLY n 
1 36  SER n 
1 37  ASN n 
1 38  LEU n 
1 39  SER n 
1 40  ASN n 
1 41  PHE n 
1 42  LEU n 
1 43  TRP n 
1 44  HIS n 
1 45  GLY n 
1 46  GLY n 
1 47  SER n 
1 48  VAL n 
1 49  TRP n 
1 50  ASP n 
1 51  ALA n 
1 52  TRP n 
1 53  PHE n 
1 54  SER n 
1 55  CYS n 
1 56  ALA n 
1 57  SER n 
1 58  ASN n 
1 59  GLN n 
1 60  VAL n 
1 61  ALA n 
1 62  GLN n 
1 63  VAL n 
1 64  LEU n 
1 65  LEU n 
1 66  THR n 
1 67  LEU n 
1 68  PRO n 
1 69  TYR n 
1 70  SER n 
1 71  PHE n 
1 72  SER n 
1 73  GLN n 
1 74  LEU n 
1 75  GLY n 
1 76  MET n 
1 77  LEU n 
1 78  SER n 
1 79  GLY n 
1 80  ILE n 
1 81  VAL n 
1 82  LEU n 
1 83  GLN n 
1 84  ILE n 
1 85  PHE n 
1 86  TYR n 
1 87  GLY n 
1 88  LEU n 
1 89  LEU n 
1 90  GLY n 
1 91  SER n 
1 92  TRP n 
1 93  THR n 
1 94  ALA n 
1 95  TYR n 
1 96  LEU n 
1 97  ILE n 
1 98  SER n 
1 99  VAL n 
1 100 LEU n 
1 101 TYR n 
1 102 VAL n 
1 103 GLU n 
1 104 TYR n 
1 105 ARG n 
1 106 ALA n 
1 107 ARG n 
1 108 LYS n 
1 109 GLU n 
1 110 LYS n 
1 111 GLU n 
1 112 GLY n 
1 113 LYS n 
1 114 SER n 
1 115 PHE n 
1 116 LYS n 
1 117 ASN n 
1 118 HIS n 
1 119 VAL n 
1 120 ILE n 
1 121 GLN n 
1 122 TRP n 
1 123 PHE n 
1 124 GLU n 
1 125 VAL n 
1 126 LEU n 
1 127 ASP n 
1 128 GLY n 
1 129 LEU n 
1 130 LEU n 
1 131 GLY n 
1 132 SER n 
1 133 TYR n 
1 134 TRP n 
1 135 LYS n 
1 136 ALA n 
1 137 LEU n 
1 138 GLY n 
1 139 LEU n 
1 140 ALA n 
1 141 PHE n 
1 142 ASN n 
1 143 CYS n 
1 144 THR n 
1 145 PHE n 
1 146 LEU n 
1 147 LEU n 
1 148 PHE n 
1 149 GLY n 
1 150 SER n 
1 151 VAL n 
1 152 ILE n 
1 153 GLN n 
1 154 LEU n 
1 155 ILE n 
1 156 ALA n 
1 157 CYS n 
1 158 ALA n 
1 159 SER n 
1 160 ASN n 
1 161 ILE n 
1 162 TYR n 
1 163 TYR n 
1 164 ILE n 
1 165 ASN n 
1 166 ASP n 
1 167 HIS n 
1 168 LEU n 
1 169 ASP n 
1 170 LYS n 
1 171 ARG n 
1 172 THR n 
1 173 TRP n 
1 174 THR n 
1 175 TYR n 
1 176 ILE n 
1 177 PHE n 
1 178 GLY n 
1 179 ALA n 
1 180 CYS n 
1 181 CYS n 
1 182 ALA n 
1 183 THR n 
1 184 THR n 
1 185 VAL n 
1 186 PHE n 
1 187 ILE n 
1 188 PRO n 
1 189 SER n 
1 190 PHE n 
1 191 HIS n 
1 192 ASN n 
1 193 TYR n 
1 194 ARG n 
1 195 ILE n 
1 196 TRP n 
1 197 SER n 
1 198 PHE n 
1 199 LEU n 
1 200 GLY n 
1 201 LEU n 
1 202 GLY n 
1 203 MET n 
1 204 THR n 
1 205 THR n 
1 206 TYR n 
1 207 THR n 
1 208 ALA n 
1 209 TRP n 
1 210 TYR n 
1 211 LEU n 
1 212 ALA n 
1 213 ILE n 
1 214 ALA n 
1 215 SER n 
1 216 ILE n 
1 217 ILE n 
1 218 HIS n 
1 219 GLY n 
1 220 GLN n 
1 221 ALA n 
1 222 GLU n 
1 223 GLY n 
1 224 VAL n 
1 225 LYS n 
1 226 HIS n 
1 227 SER n 
1 228 GLY n 
1 229 PRO n 
1 230 THR n 
1 231 LYS n 
1 232 LEU n 
1 233 VAL n 
1 234 LEU n 
1 235 TYR n 
1 236 PHE n 
1 237 THR n 
1 238 GLY n 
1 239 ALA n 
1 240 THR n 
1 241 ASN n 
1 242 ILE n 
1 243 LEU n 
1 244 TYR n 
1 245 THR n 
1 246 PHE n 
1 247 GLY n 
1 248 GLY n 
1 249 HIS n 
1 250 ALA n 
1 251 VAL n 
1 252 THR n 
1 253 VAL n 
1 254 GLU n 
1 255 ILE n 
1 256 MET n 
1 257 HIS n 
1 258 ALA n 
1 259 MET n 
1 260 TRP n 
1 261 LYS n 
1 262 PRO n 
1 263 GLN n 
1 264 LYS n 
1 265 PHE n 
1 266 LYS n 
1 267 TYR n 
1 268 ILE n 
1 269 TYR n 
1 270 LEU n 
1 271 MET n 
1 272 ALA n 
1 273 THR n 
1 274 LEU n 
1 275 TYR n 
1 276 VAL n 
1 277 PHE n 
1 278 THR n 
1 279 LEU n 
1 280 THR n 
1 281 ILE n 
1 282 PRO n 
1 283 SER n 
1 284 ALA n 
1 285 ALA n 
1 286 ALA n 
1 287 VAL n 
1 288 TYR n 
1 289 TRP n 
1 290 ALA n 
1 291 PHE n 
1 292 GLY n 
1 293 ASP n 
1 294 ALA n 
1 295 LEU n 
1 296 LEU n 
1 297 ASP n 
1 298 HIS n 
1 299 SER n 
1 300 ASN n 
1 301 ALA n 
1 302 PHE n 
1 303 SER n 
1 304 LEU n 
1 305 MET n 
1 306 PRO n 
1 307 LYS n 
1 308 ASN n 
1 309 ALA n 
1 310 TRP n 
1 311 ARG n 
1 312 ASP n 
1 313 ALA n 
1 314 ALA n 
1 315 VAL n 
1 316 ILE n 
1 317 LEU n 
1 318 MET n 
1 319 LEU n 
1 320 ILE n 
1 321 HIS n 
1 322 GLN n 
1 323 PHE n 
1 324 ILE n 
1 325 THR n 
1 326 PHE n 
1 327 GLY n 
1 328 PHE n 
1 329 ALA n 
1 330 CYS n 
1 331 THR n 
1 332 PRO n 
1 333 LEU n 
1 334 TYR n 
1 335 PHE n 
1 336 VAL n 
1 337 TRP n 
1 338 GLU n 
1 339 LYS n 
1 340 VAL n 
1 341 ILE n 
1 342 GLY n 
1 343 MET n 
1 344 HIS n 
1 345 ASP n 
1 346 THR n 
1 347 LYS n 
1 348 SER n 
1 349 ILE n 
1 350 CYS n 
1 351 LEU n 
1 352 ARG n 
1 353 ALA n 
1 354 LEU n 
1 355 ALA n 
1 356 ARG n 
1 357 LEU n 
1 358 PRO n 
1 359 VAL n 
1 360 VAL n 
1 361 ILE n 
1 362 PRO n 
1 363 ILE n 
1 364 TRP n 
1 365 PHE n 
1 366 LEU n 
1 367 ALA n 
1 368 ILE n 
1 369 ILE n 
1 370 PHE n 
1 371 PRO n 
1 372 PHE n 
1 373 PHE n 
1 374 GLY n 
1 375 PRO n 
1 376 ILE n 
1 377 ASN n 
1 378 SER n 
1 379 ALA n 
1 380 VAL n 
1 381 GLY n 
1 382 ALA n 
1 383 LEU n 
1 384 LEU n 
1 385 VAL n 
1 386 SER n 
1 387 PHE n 
1 388 THR n 
1 389 VAL n 
1 390 TYR n 
1 391 ILE n 
1 392 ILE n 
1 393 PRO n 
1 394 SER n 
1 395 LEU n 
1 396 ALA n 
1 397 HIS n 
1 398 MET n 
1 399 LEU n 
1 400 THR n 
1 401 TYR n 
1 402 ARG n 
1 403 SER n 
1 404 ALA n 
1 405 SER n 
1 406 ALA n 
1 407 ARG n 
1 408 GLN n 
1 409 ASN n 
1 410 ALA n 
1 411 ALA n 
1 412 GLU n 
1 413 LYS n 
1 414 PRO n 
1 415 PRO n 
1 416 PHE n 
1 417 PHE n 
1 418 MET n 
1 419 PRO n 
1 420 SER n 
1 421 TRP n 
1 422 THR n 
1 423 ALA n 
1 424 MET n 
1 425 TYR n 
1 426 VAL n 
1 427 LEU n 
1 428 ASN n 
1 429 ALA n 
1 430 PHE n 
1 431 VAL n 
1 432 VAL n 
1 433 VAL n 
1 434 TRP n 
1 435 VAL n 
1 436 LEU n 
1 437 ILE n 
1 438 VAL n 
1 439 GLY n 
1 440 PHE n 
1 441 GLY n 
1 442 PHE n 
1 443 GLY n 
1 444 GLY n 
1 445 TRP n 
1 446 ALA n 
1 447 SER n 
1 448 VAL n 
1 449 THR n 
1 450 ASN n 
1 451 PHE n 
1 452 VAL n 
1 453 ARG n 
1 454 GLN n 
1 455 VAL n 
1 456 ASP n 
1 457 THR n 
1 458 PHE n 
1 459 GLY n 
1 460 LEU n 
1 461 PHE n 
1 462 ALA n 
1 463 LYS n 
1 464 CYS n 
1 465 TYR n 
1 466 GLN n 
1 467 CYS n 
1 468 LYS n 
1 469 PRO n 
1 470 ALA n 
1 471 ALA n 
1 472 ALA n 
1 473 ALA n 
1 474 ALA n 
1 475 HIS n 
1 476 ALA n 
1 477 PRO n 
1 478 VAL n 
1 479 SER n 
1 480 ALA n 
1 481 LEU n 
1 482 HIS n 
1 483 HIS n 
1 484 ARG n 
1 485 LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   485 
_entity_src_gen.gene_src_common_name               'thale cress' 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'AUX1, AUX, PIR1, WAV5, At2g38120, F16M14.5' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Arabidopsis thaliana' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     3702 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Spodoptera frugiperda' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     7108 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
3C4 non-polymer         . '(3-CHLORO-4-HYDROXYPHENYL)ACETIC ACID' ? 'C8 H7 Cl O3'    186.592 
ALA 'L-peptide linking' y ALANINE                                 ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                              ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                         ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                                ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE                               ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                         ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                 ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                               ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE                              ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                 ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                  ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                              ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE                           ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                                 ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                  ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                               ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                              ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                  ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   SER 2   2   ?   ?   ?   A . n 
A 1 3   GLU 3   3   ?   ?   ?   A . n 
A 1 4   GLY 4   4   ?   ?   ?   A . n 
A 1 5   VAL 5   5   ?   ?   ?   A . n 
A 1 6   GLU 6   6   ?   ?   ?   A . n 
A 1 7   ALA 7   7   ?   ?   ?   A . n 
A 1 8   ILE 8   8   ?   ?   ?   A . n 
A 1 9   VAL 9   9   ?   ?   ?   A . n 
A 1 10  ALA 10  10  ?   ?   ?   A . n 
A 1 11  ASN 11  11  ?   ?   ?   A . n 
A 1 12  ASP 12  12  ?   ?   ?   A . n 
A 1 13  ASN 13  13  ?   ?   ?   A . n 
A 1 14  GLY 14  14  ?   ?   ?   A . n 
A 1 15  THR 15  15  ?   ?   ?   A . n 
A 1 16  ASP 16  16  ?   ?   ?   A . n 
A 1 17  GLN 17  17  ?   ?   ?   A . n 
A 1 18  VAL 18  18  ?   ?   ?   A . n 
A 1 19  ASN 19  19  ?   ?   ?   A . n 
A 1 20  GLY 20  20  ?   ?   ?   A . n 
A 1 21  ASN 21  21  ?   ?   ?   A . n 
A 1 22  ARG 22  22  ?   ?   ?   A . n 
A 1 23  THR 23  23  ?   ?   ?   A . n 
A 1 24  GLY 24  24  ?   ?   ?   A . n 
A 1 25  LYS 25  25  ?   ?   ?   A . n 
A 1 26  ASP 26  26  ?   ?   ?   A . n 
A 1 27  ASN 27  27  ?   ?   ?   A . n 
A 1 28  GLU 28  28  ?   ?   ?   A . n 
A 1 29  GLU 29  29  ?   ?   ?   A . n 
A 1 30  HIS 30  30  ?   ?   ?   A . n 
A 1 31  ASP 31  31  ?   ?   ?   A . n 
A 1 32  GLY 32  32  ?   ?   ?   A . n 
A 1 33  SER 33  33  ?   ?   ?   A . n 
A 1 34  THR 34  34  ?   ?   ?   A . n 
A 1 35  GLY 35  35  ?   ?   ?   A . n 
A 1 36  SER 36  36  ?   ?   ?   A . n 
A 1 37  ASN 37  37  ?   ?   ?   A . n 
A 1 38  LEU 38  38  ?   ?   ?   A . n 
A 1 39  SER 39  39  39  SER ALA A . n 
A 1 40  ASN 40  40  40  ASN ASN A . n 
A 1 41  PHE 41  41  41  PHE PHE A . n 
A 1 42  LEU 42  42  42  LEU LEU A . n 
A 1 43  TRP 43  43  43  TRP TRP A . n 
A 1 44  HIS 44  44  44  HIS HIS A . n 
A 1 45  GLY 45  45  45  GLY GLY A . n 
A 1 46  GLY 46  46  46  GLY GLY A . n 
A 1 47  SER 47  47  47  SER SER A . n 
A 1 48  VAL 48  48  48  VAL VAL A . n 
A 1 49  TRP 49  49  49  TRP TRP A . n 
A 1 50  ASP 50  50  50  ASP ASP A . n 
A 1 51  ALA 51  51  51  ALA ALA A . n 
A 1 52  TRP 52  52  52  TRP TRP A . n 
A 1 53  PHE 53  53  53  PHE PHE A . n 
A 1 54  SER 54  54  54  SER SER A . n 
A 1 55  CYS 55  55  55  CYS CYS A . n 
A 1 56  ALA 56  56  56  ALA ALA A . n 
A 1 57  SER 57  57  57  SER SER A . n 
A 1 58  ASN 58  58  58  ASN ASN A . n 
A 1 59  GLN 59  59  59  GLN GLN A . n 
A 1 60  VAL 60  60  60  VAL VAL A . n 
A 1 61  ALA 61  61  61  ALA ALA A . n 
A 1 62  GLN 62  62  62  GLN GLN A . n 
A 1 63  VAL 63  63  63  VAL VAL A . n 
A 1 64  LEU 64  64  64  LEU LEU A . n 
A 1 65  LEU 65  65  65  LEU LEU A . n 
A 1 66  THR 66  66  66  THR THR A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  PRO 68  68  68  PRO PRO A . n 
A 1 69  TYR 69  69  69  TYR TYR A . n 
A 1 70  SER 70  70  70  SER SER A . n 
A 1 71  PHE 71  71  71  PHE PHE A . n 
A 1 72  SER 72  72  72  SER SER A . n 
A 1 73  GLN 73  73  73  GLN GLN A . n 
A 1 74  LEU 74  74  74  LEU LEU A . n 
A 1 75  GLY 75  75  75  GLY GLY A . n 
A 1 76  MET 76  76  76  MET MET A . n 
A 1 77  LEU 77  77  77  LEU LEU A . n 
A 1 78  SER 78  78  78  SER SER A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  ILE 80  80  80  ILE ILE A . n 
A 1 81  VAL 81  81  81  VAL VAL A . n 
A 1 82  LEU 82  82  82  LEU LEU A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ILE 84  84  84  ILE ILE A . n 
A 1 85  PHE 85  85  85  PHE PHE A . n 
A 1 86  TYR 86  86  86  TYR TYR A . n 
A 1 87  GLY 87  87  87  GLY GLY A . n 
A 1 88  LEU 88  88  88  LEU LEU A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  GLY 90  90  90  GLY GLY A . n 
A 1 91  SER 91  91  91  SER SER A . n 
A 1 92  TRP 92  92  92  TRP TRP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  TYR 95  95  95  TYR TYR A . n 
A 1 96  LEU 96  96  96  LEU LEU A . n 
A 1 97  ILE 97  97  97  ILE ILE A . n 
A 1 98  SER 98  98  98  SER SER A . n 
A 1 99  VAL 99  99  99  VAL VAL A . n 
A 1 100 LEU 100 100 100 LEU LEU A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 VAL 102 102 102 VAL VAL A . n 
A 1 103 GLU 103 103 103 GLU GLU A . n 
A 1 104 TYR 104 104 104 TYR TYR A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ALA 106 106 106 ALA ALA A . n 
A 1 107 ARG 107 107 107 ARG ARG A . n 
A 1 108 LYS 108 108 108 LYS LYS A . n 
A 1 109 GLU 109 109 109 GLU GLU A . n 
A 1 110 LYS 110 110 110 LYS LYS A . n 
A 1 111 GLU 111 111 111 GLU GLU A . n 
A 1 112 GLY 112 112 112 GLY GLY A . n 
A 1 113 LYS 113 113 113 LYS LYS A . n 
A 1 114 SER 114 114 114 SER ALA A . n 
A 1 115 PHE 115 115 115 PHE PHE A . n 
A 1 116 LYS 116 116 116 LYS LYS A . n 
A 1 117 ASN 117 117 117 ASN ASN A . n 
A 1 118 HIS 118 118 118 HIS HIS A . n 
A 1 119 VAL 119 119 119 VAL VAL A . n 
A 1 120 ILE 120 120 120 ILE ILE A . n 
A 1 121 GLN 121 121 121 GLN GLN A . n 
A 1 122 TRP 122 122 122 TRP TRP A . n 
A 1 123 PHE 123 123 123 PHE PHE A . n 
A 1 124 GLU 124 124 124 GLU GLU A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 LEU 126 126 126 LEU LEU A . n 
A 1 127 ASP 127 127 127 ASP ASP A . n 
A 1 128 GLY 128 128 128 GLY GLY A . n 
A 1 129 LEU 129 129 129 LEU LEU A . n 
A 1 130 LEU 130 130 130 LEU LEU A . n 
A 1 131 GLY 131 131 131 GLY GLY A . n 
A 1 132 SER 132 132 132 SER SER A . n 
A 1 133 TYR 133 133 133 TYR TYR A . n 
A 1 134 TRP 134 134 134 TRP TRP A . n 
A 1 135 LYS 135 135 135 LYS LYS A . n 
A 1 136 ALA 136 136 136 ALA ALA A . n 
A 1 137 LEU 137 137 137 LEU LEU A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 LEU 139 139 139 LEU LEU A . n 
A 1 140 ALA 140 140 140 ALA ALA A . n 
A 1 141 PHE 141 141 141 PHE PHE A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 CYS 143 143 143 CYS CYS A . n 
A 1 144 THR 144 144 144 THR THR A . n 
A 1 145 PHE 145 145 145 PHE PHE A . n 
A 1 146 LEU 146 146 146 LEU LEU A . n 
A 1 147 LEU 147 147 147 LEU LEU A . n 
A 1 148 PHE 148 148 148 PHE PHE A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 SER 150 150 150 SER SER A . n 
A 1 151 VAL 151 151 151 VAL VAL A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 GLN 153 153 153 GLN GLN A . n 
A 1 154 LEU 154 154 154 LEU LEU A . n 
A 1 155 ILE 155 155 155 ILE ILE A . n 
A 1 156 ALA 156 156 156 ALA ALA A . n 
A 1 157 CYS 157 157 157 CYS CYS A . n 
A 1 158 ALA 158 158 158 ALA ALA A . n 
A 1 159 SER 159 159 159 SER SER A . n 
A 1 160 ASN 160 160 160 ASN ASN A . n 
A 1 161 ILE 161 161 161 ILE ILE A . n 
A 1 162 TYR 162 162 162 TYR TYR A . n 
A 1 163 TYR 163 163 163 TYR TYR A . n 
A 1 164 ILE 164 164 164 ILE ILE A . n 
A 1 165 ASN 165 165 165 ASN ASN A . n 
A 1 166 ASP 166 166 166 ASP ASP A . n 
A 1 167 HIS 167 167 167 HIS HIS A . n 
A 1 168 LEU 168 168 168 LEU LEU A . n 
A 1 169 ASP 169 169 169 ASP ASP A . n 
A 1 170 LYS 170 170 170 LYS LYS A . n 
A 1 171 ARG 171 171 171 ARG ARG A . n 
A 1 172 THR 172 172 172 THR THR A . n 
A 1 173 TRP 173 173 173 TRP TRP A . n 
A 1 174 THR 174 174 174 THR THR A . n 
A 1 175 TYR 175 175 175 TYR TYR A . n 
A 1 176 ILE 176 176 176 ILE ILE A . n 
A 1 177 PHE 177 177 177 PHE PHE A . n 
A 1 178 GLY 178 178 178 GLY GLY A . n 
A 1 179 ALA 179 179 179 ALA ALA A . n 
A 1 180 CYS 180 180 180 CYS CYS A . n 
A 1 181 CYS 181 181 181 CYS CYS A . n 
A 1 182 ALA 182 182 182 ALA ALA A . n 
A 1 183 THR 183 183 183 THR THR A . n 
A 1 184 THR 184 184 184 THR THR A . n 
A 1 185 VAL 185 185 185 VAL VAL A . n 
A 1 186 PHE 186 186 186 PHE PHE A . n 
A 1 187 ILE 187 187 187 ILE ILE A . n 
A 1 188 PRO 188 188 188 PRO PRO A . n 
A 1 189 SER 189 189 189 SER SER A . n 
A 1 190 PHE 190 190 190 PHE PHE A . n 
A 1 191 HIS 191 191 191 HIS HIS A . n 
A 1 192 ASN 192 192 192 ASN ASN A . n 
A 1 193 TYR 193 193 193 TYR TYR A . n 
A 1 194 ARG 194 194 194 ARG ARG A . n 
A 1 195 ILE 195 195 195 ILE ILE A . n 
A 1 196 TRP 196 196 196 TRP TRP A . n 
A 1 197 SER 197 197 197 SER SER A . n 
A 1 198 PHE 198 198 198 PHE PHE A . n 
A 1 199 LEU 199 199 199 LEU LEU A . n 
A 1 200 GLY 200 200 200 GLY GLY A . n 
A 1 201 LEU 201 201 201 LEU LEU A . n 
A 1 202 GLY 202 202 202 GLY GLY A . n 
A 1 203 MET 203 203 203 MET MET A . n 
A 1 204 THR 204 204 204 THR THR A . n 
A 1 205 THR 205 205 205 THR THR A . n 
A 1 206 TYR 206 206 206 TYR TYR A . n 
A 1 207 THR 207 207 207 THR THR A . n 
A 1 208 ALA 208 208 208 ALA ALA A . n 
A 1 209 TRP 209 209 209 TRP TRP A . n 
A 1 210 TYR 210 210 210 TYR TYR A . n 
A 1 211 LEU 211 211 211 LEU LEU A . n 
A 1 212 ALA 212 212 212 ALA ALA A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ALA 214 214 214 ALA ALA A . n 
A 1 215 SER 215 215 215 SER SER A . n 
A 1 216 ILE 216 216 216 ILE ILE A . n 
A 1 217 ILE 217 217 217 ILE ILE A . n 
A 1 218 HIS 218 218 218 HIS HIS A . n 
A 1 219 GLY 219 219 219 GLY GLY A . n 
A 1 220 GLN 220 220 220 GLN GLN A . n 
A 1 221 ALA 221 221 221 ALA ALA A . n 
A 1 222 GLU 222 222 222 GLU GLU A . n 
A 1 223 GLY 223 223 223 GLY GLY A . n 
A 1 224 VAL 224 224 224 VAL VAL A . n 
A 1 225 LYS 225 225 225 LYS LYS A . n 
A 1 226 HIS 226 226 226 HIS HIS A . n 
A 1 227 SER 227 227 227 SER SER A . n 
A 1 228 GLY 228 228 228 GLY GLY A . n 
A 1 229 PRO 229 229 229 PRO PRO A . n 
A 1 230 THR 230 230 230 THR THR A . n 
A 1 231 LYS 231 231 231 LYS LYS A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 LEU 234 234 234 LEU LEU A . n 
A 1 235 TYR 235 235 235 TYR TYR A . n 
A 1 236 PHE 236 236 236 PHE PHE A . n 
A 1 237 THR 237 237 237 THR THR A . n 
A 1 238 GLY 238 238 238 GLY GLY A . n 
A 1 239 ALA 239 239 239 ALA ALA A . n 
A 1 240 THR 240 240 240 THR THR A . n 
A 1 241 ASN 241 241 241 ASN ASN A . n 
A 1 242 ILE 242 242 242 ILE ILE A . n 
A 1 243 LEU 243 243 243 LEU LEU A . n 
A 1 244 TYR 244 244 244 TYR TYR A . n 
A 1 245 THR 245 245 245 THR THR A . n 
A 1 246 PHE 246 246 246 PHE PHE A . n 
A 1 247 GLY 247 247 247 GLY GLY A . n 
A 1 248 GLY 248 248 248 GLY GLY A . n 
A 1 249 HIS 249 249 249 HIS HIS A . n 
A 1 250 ALA 250 250 250 ALA ALA A . n 
A 1 251 VAL 251 251 251 VAL VAL A . n 
A 1 252 THR 252 252 252 THR THR A . n 
A 1 253 VAL 253 253 253 VAL VAL A . n 
A 1 254 GLU 254 254 254 GLU GLU A . n 
A 1 255 ILE 255 255 255 ILE ILE A . n 
A 1 256 MET 256 256 256 MET MET A . n 
A 1 257 HIS 257 257 257 HIS HIS A . n 
A 1 258 ALA 258 258 258 ALA ALA A . n 
A 1 259 MET 259 259 259 MET MET A . n 
A 1 260 TRP 260 260 260 TRP TRP A . n 
A 1 261 LYS 261 261 261 LYS LYS A . n 
A 1 262 PRO 262 262 262 PRO PRO A . n 
A 1 263 GLN 263 263 263 GLN GLN A . n 
A 1 264 LYS 264 264 264 LYS LYS A . n 
A 1 265 PHE 265 265 265 PHE PHE A . n 
A 1 266 LYS 266 266 266 LYS LYS A . n 
A 1 267 TYR 267 267 267 TYR TYR A . n 
A 1 268 ILE 268 268 268 ILE ILE A . n 
A 1 269 TYR 269 269 269 TYR TYR A . n 
A 1 270 LEU 270 270 270 LEU LEU A . n 
A 1 271 MET 271 271 271 MET MET A . n 
A 1 272 ALA 272 272 272 ALA ALA A . n 
A 1 273 THR 273 273 273 THR THR A . n 
A 1 274 LEU 274 274 274 LEU LEU A . n 
A 1 275 TYR 275 275 275 TYR TYR A . n 
A 1 276 VAL 276 276 276 VAL VAL A . n 
A 1 277 PHE 277 277 277 PHE PHE A . n 
A 1 278 THR 278 278 278 THR THR A . n 
A 1 279 LEU 279 279 279 LEU LEU A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 PRO 282 282 282 PRO PRO A . n 
A 1 283 SER 283 283 283 SER SER A . n 
A 1 284 ALA 284 284 284 ALA ALA A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 ALA 286 286 286 ALA ALA A . n 
A 1 287 VAL 287 287 287 VAL VAL A . n 
A 1 288 TYR 288 288 288 TYR TYR A . n 
A 1 289 TRP 289 289 289 TRP TRP A . n 
A 1 290 ALA 290 290 290 ALA ALA A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 GLY 292 292 292 GLY GLY A . n 
A 1 293 ASP 293 293 293 ASP ASP A . n 
A 1 294 ALA 294 294 294 ALA ALA A . n 
A 1 295 LEU 295 295 295 LEU LEU A . n 
A 1 296 LEU 296 296 296 LEU LEU A . n 
A 1 297 ASP 297 297 297 ASP ASP A . n 
A 1 298 HIS 298 298 298 HIS HIS A . n 
A 1 299 SER 299 299 299 SER SER A . n 
A 1 300 ASN 300 300 300 ASN ASN A . n 
A 1 301 ALA 301 301 301 ALA ALA A . n 
A 1 302 PHE 302 302 302 PHE PHE A . n 
A 1 303 SER 303 303 303 SER SER A . n 
A 1 304 LEU 304 304 304 LEU LEU A . n 
A 1 305 MET 305 305 305 MET MET A . n 
A 1 306 PRO 306 306 306 PRO PRO A . n 
A 1 307 LYS 307 307 307 LYS LYS A . n 
A 1 308 ASN 308 308 308 ASN ASN A . n 
A 1 309 ALA 309 309 309 ALA ALA A . n 
A 1 310 TRP 310 310 310 TRP TRP A . n 
A 1 311 ARG 311 311 311 ARG ARG A . n 
A 1 312 ASP 312 312 312 ASP ASP A . n 
A 1 313 ALA 313 313 313 ALA ALA A . n 
A 1 314 ALA 314 314 314 ALA ALA A . n 
A 1 315 VAL 315 315 315 VAL VAL A . n 
A 1 316 ILE 316 316 316 ILE ILE A . n 
A 1 317 LEU 317 317 317 LEU LEU A . n 
A 1 318 MET 318 318 318 MET MET A . n 
A 1 319 LEU 319 319 319 LEU LEU A . n 
A 1 320 ILE 320 320 320 ILE ILE A . n 
A 1 321 HIS 321 321 321 HIS HIS A . n 
A 1 322 GLN 322 322 322 GLN GLN A . n 
A 1 323 PHE 323 323 323 PHE PHE A . n 
A 1 324 ILE 324 324 324 ILE ILE A . n 
A 1 325 THR 325 325 325 THR THR A . n 
A 1 326 PHE 326 326 326 PHE PHE A . n 
A 1 327 GLY 327 327 327 GLY GLY A . n 
A 1 328 PHE 328 328 328 PHE PHE A . n 
A 1 329 ALA 329 329 329 ALA ALA A . n 
A 1 330 CYS 330 330 330 CYS CYS A . n 
A 1 331 THR 331 331 331 THR THR A . n 
A 1 332 PRO 332 332 332 PRO PRO A . n 
A 1 333 LEU 333 333 333 LEU LEU A . n 
A 1 334 TYR 334 334 334 TYR TYR A . n 
A 1 335 PHE 335 335 335 PHE PHE A . n 
A 1 336 VAL 336 336 336 VAL VAL A . n 
A 1 337 TRP 337 337 337 TRP TRP A . n 
A 1 338 GLU 338 338 338 GLU GLU A . n 
A 1 339 LYS 339 339 339 LYS LYS A . n 
A 1 340 VAL 340 340 340 VAL VAL A . n 
A 1 341 ILE 341 341 341 ILE ILE A . n 
A 1 342 GLY 342 342 342 GLY GLY A . n 
A 1 343 MET 343 343 343 MET MET A . n 
A 1 344 HIS 344 344 344 HIS HIS A . n 
A 1 345 ASP 345 345 345 ASP ASP A . n 
A 1 346 THR 346 346 346 THR THR A . n 
A 1 347 LYS 347 347 347 LYS LYS A . n 
A 1 348 SER 348 348 348 SER SER A . n 
A 1 349 ILE 349 349 349 ILE ILE A . n 
A 1 350 CYS 350 350 350 CYS CYS A . n 
A 1 351 LEU 351 351 351 LEU LEU A . n 
A 1 352 ARG 352 352 352 ARG ARG A . n 
A 1 353 ALA 353 353 353 ALA ALA A . n 
A 1 354 LEU 354 354 354 LEU LEU A . n 
A 1 355 ALA 355 355 355 ALA ALA A . n 
A 1 356 ARG 356 356 356 ARG ARG A . n 
A 1 357 LEU 357 357 357 LEU LEU A . n 
A 1 358 PRO 358 358 358 PRO PRO A . n 
A 1 359 VAL 359 359 359 VAL VAL A . n 
A 1 360 VAL 360 360 360 VAL VAL A . n 
A 1 361 ILE 361 361 361 ILE ILE A . n 
A 1 362 PRO 362 362 362 PRO PRO A . n 
A 1 363 ILE 363 363 363 ILE ILE A . n 
A 1 364 TRP 364 364 364 TRP TRP A . n 
A 1 365 PHE 365 365 365 PHE PHE A . n 
A 1 366 LEU 366 366 366 LEU LEU A . n 
A 1 367 ALA 367 367 367 ALA ALA A . n 
A 1 368 ILE 368 368 368 ILE ILE A . n 
A 1 369 ILE 369 369 369 ILE ILE A . n 
A 1 370 PHE 370 370 370 PHE PHE A . n 
A 1 371 PRO 371 371 371 PRO PRO A . n 
A 1 372 PHE 372 372 372 PHE PHE A . n 
A 1 373 PHE 373 373 373 PHE PHE A . n 
A 1 374 GLY 374 374 374 GLY GLY A . n 
A 1 375 PRO 375 375 375 PRO PRO A . n 
A 1 376 ILE 376 376 376 ILE ILE A . n 
A 1 377 ASN 377 377 377 ASN ASN A . n 
A 1 378 SER 378 378 378 SER SER A . n 
A 1 379 ALA 379 379 379 ALA ALA A . n 
A 1 380 VAL 380 380 380 VAL VAL A . n 
A 1 381 GLY 381 381 381 GLY GLY A . n 
A 1 382 ALA 382 382 382 ALA ALA A . n 
A 1 383 LEU 383 383 383 LEU LEU A . n 
A 1 384 LEU 384 384 384 LEU LEU A . n 
A 1 385 VAL 385 385 385 VAL VAL A . n 
A 1 386 SER 386 386 386 SER SER A . n 
A 1 387 PHE 387 387 387 PHE PHE A . n 
A 1 388 THR 388 388 388 THR THR A . n 
A 1 389 VAL 389 389 389 VAL VAL A . n 
A 1 390 TYR 390 390 390 TYR TYR A . n 
A 1 391 ILE 391 391 391 ILE ILE A . n 
A 1 392 ILE 392 392 392 ILE ILE A . n 
A 1 393 PRO 393 393 393 PRO PRO A . n 
A 1 394 SER 394 394 394 SER SER A . n 
A 1 395 LEU 395 395 395 LEU LEU A . n 
A 1 396 ALA 396 396 396 ALA ALA A . n 
A 1 397 HIS 397 397 397 HIS HIS A . n 
A 1 398 MET 398 398 398 MET MET A . n 
A 1 399 LEU 399 399 399 LEU LEU A . n 
A 1 400 THR 400 400 400 THR THR A . n 
A 1 401 TYR 401 401 401 TYR TYR A . n 
A 1 402 ARG 402 402 402 ARG ARG A . n 
A 1 403 SER 403 403 403 SER SER A . n 
A 1 404 ALA 404 404 404 ALA ALA A . n 
A 1 405 SER 405 405 405 SER SER A . n 
A 1 406 ALA 406 406 406 ALA ALA A . n 
A 1 407 ARG 407 407 407 ARG ARG A . n 
A 1 408 GLN 408 408 408 GLN GLN A . n 
A 1 409 ASN 409 409 409 ASN ASN A . n 
A 1 410 ALA 410 410 410 ALA ALA A . n 
A 1 411 ALA 411 411 411 ALA ALA A . n 
A 1 412 GLU 412 412 412 GLU GLU A . n 
A 1 413 LYS 413 413 413 LYS LYS A . n 
A 1 414 PRO 414 414 414 PRO PRO A . n 
A 1 415 PRO 415 415 415 PRO PRO A . n 
A 1 416 PHE 416 416 416 PHE PHE A . n 
A 1 417 PHE 417 417 417 PHE PHE A . n 
A 1 418 MET 418 418 418 MET MET A . n 
A 1 419 PRO 419 419 419 PRO PRO A . n 
A 1 420 SER 420 420 420 SER SER A . n 
A 1 421 TRP 421 421 421 TRP TRP A . n 
A 1 422 THR 422 422 422 THR THR A . n 
A 1 423 ALA 423 423 423 ALA ALA A . n 
A 1 424 MET 424 424 424 MET MET A . n 
A 1 425 TYR 425 425 425 TYR TYR A . n 
A 1 426 VAL 426 426 426 VAL VAL A . n 
A 1 427 LEU 427 427 427 LEU LEU A . n 
A 1 428 ASN 428 428 428 ASN ASN A . n 
A 1 429 ALA 429 429 429 ALA ALA A . n 
A 1 430 PHE 430 430 430 PHE PHE A . n 
A 1 431 VAL 431 431 431 VAL VAL A . n 
A 1 432 VAL 432 432 432 VAL VAL A . n 
A 1 433 VAL 433 433 433 VAL VAL A . n 
A 1 434 TRP 434 434 434 TRP TRP A . n 
A 1 435 VAL 435 435 435 VAL VAL A . n 
A 1 436 LEU 436 436 436 LEU LEU A . n 
A 1 437 ILE 437 437 437 ILE ILE A . n 
A 1 438 VAL 438 438 438 VAL VAL A . n 
A 1 439 GLY 439 439 439 GLY GLY A . n 
A 1 440 PHE 440 440 440 PHE PHE A . n 
A 1 441 GLY 441 441 441 GLY GLY A . n 
A 1 442 PHE 442 442 442 PHE PHE A . n 
A 1 443 GLY 443 443 443 GLY GLY A . n 
A 1 444 GLY 444 444 444 GLY GLY A . n 
A 1 445 TRP 445 445 445 TRP TRP A . n 
A 1 446 ALA 446 446 446 ALA ALA A . n 
A 1 447 SER 447 447 447 SER SER A . n 
A 1 448 VAL 448 448 448 VAL VAL A . n 
A 1 449 THR 449 449 449 THR THR A . n 
A 1 450 ASN 450 450 450 ASN ASN A . n 
A 1 451 PHE 451 451 451 PHE PHE A . n 
A 1 452 VAL 452 452 452 VAL VAL A . n 
A 1 453 ARG 453 453 453 ARG ARG A . n 
A 1 454 GLN 454 454 454 GLN GLN A . n 
A 1 455 VAL 455 455 455 VAL VAL A . n 
A 1 456 ASP 456 456 456 ASP ASP A . n 
A 1 457 THR 457 457 457 THR THR A . n 
A 1 458 PHE 458 458 458 PHE PHE A . n 
A 1 459 GLY 459 459 459 GLY GLY A . n 
A 1 460 LEU 460 460 460 LEU LEU A . n 
A 1 461 PHE 461 461 461 PHE PHE A . n 
A 1 462 ALA 462 462 462 ALA ALA A . n 
A 1 463 LYS 463 463 463 LYS LYS A . n 
A 1 464 CYS 464 464 464 CYS CYS A . n 
A 1 465 TYR 465 465 465 TYR TYR A . n 
A 1 466 GLN 466 466 466 GLN GLN A . n 
A 1 467 CYS 467 467 467 CYS CYS A . n 
A 1 468 LYS 468 468 468 LYS LYS A . n 
A 1 469 PRO 469 469 469 PRO PRO A . n 
A 1 470 ALA 470 470 ?   ?   ?   A . n 
A 1 471 ALA 471 471 ?   ?   ?   A . n 
A 1 472 ALA 472 472 ?   ?   ?   A . n 
A 1 473 ALA 473 473 ?   ?   ?   A . n 
A 1 474 ALA 474 474 ?   ?   ?   A . n 
A 1 475 HIS 475 475 ?   ?   ?   A . n 
A 1 476 ALA 476 476 ?   ?   ?   A . n 
A 1 477 PRO 477 477 ?   ?   ?   A . n 
A 1 478 VAL 478 478 ?   ?   ?   A . n 
A 1 479 SER 479 479 ?   ?   ?   A . n 
A 1 480 ALA 480 480 ?   ?   ?   A . n 
A 1 481 LEU 481 481 ?   ?   ?   A . n 
A 1 482 HIS 482 482 ?   ?   ?   A . n 
A 1 483 HIS 483 483 ?   ?   ?   A . n 
A 1 484 ARG 484 484 ?   ?   ?   A . n 
A 1 485 LEU 485 485 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        3C4 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   3C4 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
_pdbx_nonpoly_scheme.asym_id         B 
_pdbx_nonpoly_scheme.entity_id       2 
_pdbx_nonpoly_scheme.mon_id          3C4 
_pdbx_nonpoly_scheme.ndb_seq_num     1 
_pdbx_nonpoly_scheme.pdb_seq_num     501 
_pdbx_nonpoly_scheme.auth_seq_num    501 
_pdbx_nonpoly_scheme.pdb_mon_id      3C4 
_pdbx_nonpoly_scheme.auth_mon_id     UNL 
_pdbx_nonpoly_scheme.pdb_strand_id   A 
_pdbx_nonpoly_scheme.pdb_ins_code    . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A SER 39  ? OG ? A SER 39  OG 
2 1 Y 1 A SER 114 ? OG ? A SER 114 OG 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9M2H 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9M2H 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9M2H 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     9M2H 
_struct.title                        'Structure of the auxin importer AUX1 in Arabidopsis thaliana in the CHPAA-bound state' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9M2H 
_struct_keywords.text            'Auxin, importer, AUX1, MEMBRANE PROTEIN' 
_struct_keywords.pdbx_keywords   'MEMBRANE PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    AUX1_ARATH 
_struct_ref.pdbx_db_accession          Q96247 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MSEGVEAIVANDNGTDQVNGNRTGKDNEEHDGSTGSNLSNFLWHGGSVWDAWFSCASNQVAQVLLTLPYSFSQLGMLSGI
VLQIFYGLLGSWTAYLISVLYVEYRARKEKEGKSFKNHVIQWFEVLDGLLGSYWKALGLAFNCTFLLFGSVIQLIACASN
IYYINDHLDKRTWTYIFGACCATTVFIPSFHNYRIWSFLGLGMTTYTAWYLAIASIIHGQAEGVKHSGPTKLVLYFTGAT
NILYTFGGHAVTVEIMHAMWKPQKFKYIYLMATLYVFTLTIPSAAAVYWAFGDALLDHSNAFSLMPKNAWRDAAVILMLI
HQFITFGFACTPLYFVWEKVIGMHDTKSICLRALARLPVVIPIWFLAIIFPFFGPINSAVGALLVSFTVYIIPSLAHMLT
YRSASARQNAAEKPPFFMPSWTAMYVLNAFVVVWVLIVGFGFGGWASVTNFVRQVDTFGLFAKCYQCKPAAAAAHAPVSA
LHHRL
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9M2H 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 485 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q96247 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  485 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       485 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 47  ? ASN A 58  ? SER A 47  ASN A 58  1 ? 12 
HELX_P HELX_P2  AA2 GLN A 62  ? GLY A 75  ? GLN A 62  GLY A 75  1 ? 14 
HELX_P HELX_P3  AA3 MET A 76  ? ALA A 106 ? MET A 76  ALA A 106 1 ? 31 
HELX_P HELX_P4  AA4 GLN A 121 ? GLY A 131 ? GLN A 121 GLY A 131 1 ? 11 
HELX_P HELX_P5  AA5 LYS A 135 ? THR A 144 ? LYS A 135 THR A 144 1 ? 10 
HELX_P HELX_P6  AA6 THR A 144 ? TYR A 162 ? THR A 144 TYR A 162 1 ? 19 
HELX_P HELX_P7  AA7 ARG A 171 ? ALA A 182 ? ARG A 171 ALA A 182 1 ? 12 
HELX_P HELX_P8  AA8 THR A 183 ? PHE A 186 ? THR A 183 PHE A 186 5 ? 4  
HELX_P HELX_P9  AA9 ARG A 194 ? LEU A 199 ? ARG A 194 LEU A 199 1 ? 6  
HELX_P HELX_P10 AB1 LEU A 199 ? ILE A 217 ? LEU A 199 ILE A 217 1 ? 19 
HELX_P HELX_P11 AB2 VAL A 233 ? GLY A 238 ? VAL A 233 GLY A 238 1 ? 6  
HELX_P HELX_P12 AB3 ALA A 239 ? TYR A 244 ? ALA A 239 TYR A 244 1 ? 6  
HELX_P HELX_P13 AB4 VAL A 251 ? HIS A 257 ? VAL A 251 HIS A 257 1 ? 7  
HELX_P HELX_P14 AB5 LYS A 264 ? GLY A 292 ? LYS A 264 GLY A 292 1 ? 29 
HELX_P HELX_P15 AB6 ASP A 293 ? LEU A 295 ? ASP A 293 LEU A 295 5 ? 3  
HELX_P HELX_P16 AB7 TRP A 310 ? ILE A 341 ? TRP A 310 ILE A 341 1 ? 32 
HELX_P HELX_P17 AB8 SER A 348 ? ARG A 356 ? SER A 348 ARG A 356 1 ? 9  
HELX_P HELX_P18 AB9 ARG A 356 ? PHE A 370 ? ARG A 356 PHE A 370 1 ? 15 
HELX_P HELX_P19 AC1 PRO A 375 ? LEU A 384 ? PRO A 375 LEU A 384 1 ? 10 
HELX_P HELX_P20 AC2 LEU A 384 ? TYR A 390 ? LEU A 384 TYR A 390 1 ? 7  
HELX_P HELX_P21 AC3 ILE A 391 ? TYR A 401 ? ILE A 391 TYR A 401 1 ? 11 
HELX_P HELX_P22 AC4 SER A 403 ? ASN A 409 ? SER A 403 ASN A 409 1 ? 7  
HELX_P HELX_P23 AC5 TRP A 421 ? GLY A 439 ? TRP A 421 GLY A 439 1 ? 19 
HELX_P HELX_P24 AC6 GLY A 441 ? GLY A 459 ? GLY A 441 GLY A 459 1 ? 19 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            disulf1 
_struct_conn.conn_type_id                  disulf 
_struct_conn.pdbx_leaving_atom_flag        ? 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            464 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           A 
_struct_conn.ptnr2_label_comp_id           CYS 
_struct_conn.ptnr2_label_seq_id            467 
_struct_conn.ptnr2_label_atom_id           SG 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             464 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            CYS 
_struct_conn.ptnr2_auth_seq_id             467 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               2.024 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      CYS 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       464 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      467 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       CYS 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        464 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       467 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               SG 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                . 
_pdbx_modification_feature.ref_pcm_id                         . 
_pdbx_modification_feature.ref_comp_id                        . 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Disulfide bridge' 
# 
_pdbx_entry_details.entry_id                   9M2H 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 CA A TRP 122 ? ? CB A TRP 122 ? ? CG A TRP 122 ? ? 126.47 113.70 12.77  1.90 N 
2 1 CB A CYS 143 ? ? CA A CYS 143 ? ? C  A CYS 143 ? ? 119.22 111.50 7.72   1.20 N 
3 1 CB A CYS 181 ? ? CA A CYS 181 ? ? C  A CYS 181 ? ? 119.67 111.50 8.17   1.20 N 
4 1 CB A ALA 313 ? ? CA A ALA 313 ? ? C  A ALA 313 ? ? 120.12 110.10 10.02  1.50 N 
5 1 CB A ALA 314 ? ? CA A ALA 314 ? ? C  A ALA 314 ? ? 120.79 110.10 10.69  1.50 N 
6 1 CB A LEU 317 ? ? CA A LEU 317 ? ? C  A LEU 317 ? ? 123.87 110.20 13.67  1.90 N 
7 1 N  A MET 418 ? ? CA A MET 418 ? ? C  A MET 418 ? ? 91.24  111.00 -19.76 2.70 N 
8 1 N  A SER 420 ? ? CA A SER 420 ? ? CB A SER 420 ? ? 100.57 110.50 -9.93  1.50 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 PHE A 41  ? ? -141.10 58.26   
2 1 HIS A 44  ? ? 57.66   15.46   
3 1 SER A 132 ? ? 68.87   -7.23   
4 1 HIS A 191 ? ? -140.15 -158.57 
5 1 ARG A 194 ? ? -90.97  -61.67  
6 1 ASN A 308 ? ? -135.38 -159.84 
7 1 PRO A 371 ? ? -89.18  47.91   
8 1 TYR A 401 ? ? -94.05  46.70   
9 1 PRO A 419 ? ? -108.43 46.16   
# 
_pdbx_validate_polymer_linkage.id               1 
_pdbx_validate_polymer_linkage.PDB_model_num    1 
_pdbx_validate_polymer_linkage.auth_atom_id_1   C 
_pdbx_validate_polymer_linkage.auth_asym_id_1   A 
_pdbx_validate_polymer_linkage.auth_comp_id_1   LYS 
_pdbx_validate_polymer_linkage.auth_seq_id_1    113 
_pdbx_validate_polymer_linkage.PDB_ins_code_1   ? 
_pdbx_validate_polymer_linkage.label_alt_id_1   ? 
_pdbx_validate_polymer_linkage.auth_atom_id_2   N 
_pdbx_validate_polymer_linkage.auth_asym_id_2   A 
_pdbx_validate_polymer_linkage.auth_comp_id_2   SER 
_pdbx_validate_polymer_linkage.auth_seq_id_2    114 
_pdbx_validate_polymer_linkage.PDB_ins_code_2   ? 
_pdbx_validate_polymer_linkage.label_alt_id_2   ? 
_pdbx_validate_polymer_linkage.dist             19.23 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9M2H 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9M2H 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.4 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               239360 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.4 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'AUX1 protein in complex with CHPAA' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        9M2H 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               OTHER 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1000 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
_em_imaging.objective_aperture              ? 
_em_imaging.microscope_serial_number        ? 
_em_imaging.microscope_version              ? 
# 
_em_vitrification.entry_id              9M2H 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9M2H 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A SER 2   ? A SER 2   
3  1 Y 1 A GLU 3   ? A GLU 3   
4  1 Y 1 A GLY 4   ? A GLY 4   
5  1 Y 1 A VAL 5   ? A VAL 5   
6  1 Y 1 A GLU 6   ? A GLU 6   
7  1 Y 1 A ALA 7   ? A ALA 7   
8  1 Y 1 A ILE 8   ? A ILE 8   
9  1 Y 1 A VAL 9   ? A VAL 9   
10 1 Y 1 A ALA 10  ? A ALA 10  
11 1 Y 1 A ASN 11  ? A ASN 11  
12 1 Y 1 A ASP 12  ? A ASP 12  
13 1 Y 1 A ASN 13  ? A ASN 13  
14 1 Y 1 A GLY 14  ? A GLY 14  
15 1 Y 1 A THR 15  ? A THR 15  
16 1 Y 1 A ASP 16  ? A ASP 16  
17 1 Y 1 A GLN 17  ? A GLN 17  
18 1 Y 1 A VAL 18  ? A VAL 18  
19 1 Y 1 A ASN 19  ? A ASN 19  
20 1 Y 1 A GLY 20  ? A GLY 20  
21 1 Y 1 A ASN 21  ? A ASN 21  
22 1 Y 1 A ARG 22  ? A ARG 22  
23 1 Y 1 A THR 23  ? A THR 23  
24 1 Y 1 A GLY 24  ? A GLY 24  
25 1 Y 1 A LYS 25  ? A LYS 25  
26 1 Y 1 A ASP 26  ? A ASP 26  
27 1 Y 1 A ASN 27  ? A ASN 27  
28 1 Y 1 A GLU 28  ? A GLU 28  
29 1 Y 1 A GLU 29  ? A GLU 29  
30 1 Y 1 A HIS 30  ? A HIS 30  
31 1 Y 1 A ASP 31  ? A ASP 31  
32 1 Y 1 A GLY 32  ? A GLY 32  
33 1 Y 1 A SER 33  ? A SER 33  
34 1 Y 1 A THR 34  ? A THR 34  
35 1 Y 1 A GLY 35  ? A GLY 35  
36 1 Y 1 A SER 36  ? A SER 36  
37 1 Y 1 A ASN 37  ? A ASN 37  
38 1 Y 1 A LEU 38  ? A LEU 38  
39 1 Y 1 A ALA 470 ? A ALA 470 
40 1 Y 1 A ALA 471 ? A ALA 471 
41 1 Y 1 A ALA 472 ? A ALA 472 
42 1 Y 1 A ALA 473 ? A ALA 473 
43 1 Y 1 A ALA 474 ? A ALA 474 
44 1 Y 1 A HIS 475 ? A HIS 475 
45 1 Y 1 A ALA 476 ? A ALA 476 
46 1 Y 1 A PRO 477 ? A PRO 477 
47 1 Y 1 A VAL 478 ? A VAL 478 
48 1 Y 1 A SER 479 ? A SER 479 
49 1 Y 1 A ALA 480 ? A ALA 480 
50 1 Y 1 A LEU 481 ? A LEU 481 
51 1 Y 1 A HIS 482 ? A HIS 482 
52 1 Y 1 A HIS 483 ? A HIS 483 
53 1 Y 1 A ARG 484 ? A ARG 484 
54 1 Y 1 A LEU 485 ? A LEU 485 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
3C4 O2   O  N N 1   
3C4 C    C  N N 2   
3C4 O1   O  N N 3   
3C4 CG   C  N N 4   
3C4 CA   C  Y N 5   
3C4 CD2  C  Y N 6   
3C4 CE2  C  Y N 7   
3C4 CZ   C  Y N 8   
3C4 OH   O  N N 9   
3C4 CL   CL N N 10  
3C4 CE1  C  Y N 11  
3C4 CD1  C  Y N 12  
3C4 HO1  H  N N 13  
3C4 HG1  H  N N 14  
3C4 HG2  H  N N 15  
3C4 HD2  H  N N 16  
3C4 HE2  H  N N 17  
3C4 HOH  H  N N 18  
3C4 HD1  H  N N 19  
ALA N    N  N N 20  
ALA CA   C  N S 21  
ALA C    C  N N 22  
ALA O    O  N N 23  
ALA CB   C  N N 24  
ALA OXT  O  N N 25  
ALA H    H  N N 26  
ALA H2   H  N N 27  
ALA HA   H  N N 28  
ALA HB1  H  N N 29  
ALA HB2  H  N N 30  
ALA HB3  H  N N 31  
ALA HXT  H  N N 32  
ARG N    N  N N 33  
ARG CA   C  N S 34  
ARG C    C  N N 35  
ARG O    O  N N 36  
ARG CB   C  N N 37  
ARG CG   C  N N 38  
ARG CD   C  N N 39  
ARG NE   N  N N 40  
ARG CZ   C  N N 41  
ARG NH1  N  N N 42  
ARG NH2  N  N N 43  
ARG OXT  O  N N 44  
ARG H    H  N N 45  
ARG H2   H  N N 46  
ARG HA   H  N N 47  
ARG HB2  H  N N 48  
ARG HB3  H  N N 49  
ARG HG2  H  N N 50  
ARG HG3  H  N N 51  
ARG HD2  H  N N 52  
ARG HD3  H  N N 53  
ARG HE   H  N N 54  
ARG HH11 H  N N 55  
ARG HH12 H  N N 56  
ARG HH21 H  N N 57  
ARG HH22 H  N N 58  
ARG HXT  H  N N 59  
ASN N    N  N N 60  
ASN CA   C  N S 61  
ASN C    C  N N 62  
ASN O    O  N N 63  
ASN CB   C  N N 64  
ASN CG   C  N N 65  
ASN OD1  O  N N 66  
ASN ND2  N  N N 67  
ASN OXT  O  N N 68  
ASN H    H  N N 69  
ASN H2   H  N N 70  
ASN HA   H  N N 71  
ASN HB2  H  N N 72  
ASN HB3  H  N N 73  
ASN HD21 H  N N 74  
ASN HD22 H  N N 75  
ASN HXT  H  N N 76  
ASP N    N  N N 77  
ASP CA   C  N S 78  
ASP C    C  N N 79  
ASP O    O  N N 80  
ASP CB   C  N N 81  
ASP CG   C  N N 82  
ASP OD1  O  N N 83  
ASP OD2  O  N N 84  
ASP OXT  O  N N 85  
ASP H    H  N N 86  
ASP H2   H  N N 87  
ASP HA   H  N N 88  
ASP HB2  H  N N 89  
ASP HB3  H  N N 90  
ASP HD2  H  N N 91  
ASP HXT  H  N N 92  
CYS N    N  N N 93  
CYS CA   C  N R 94  
CYS C    C  N N 95  
CYS O    O  N N 96  
CYS CB   C  N N 97  
CYS SG   S  N N 98  
CYS OXT  O  N N 99  
CYS H    H  N N 100 
CYS H2   H  N N 101 
CYS HA   H  N N 102 
CYS HB2  H  N N 103 
CYS HB3  H  N N 104 
CYS HG   H  N N 105 
CYS HXT  H  N N 106 
GLN N    N  N N 107 
GLN CA   C  N S 108 
GLN C    C  N N 109 
GLN O    O  N N 110 
GLN CB   C  N N 111 
GLN CG   C  N N 112 
GLN CD   C  N N 113 
GLN OE1  O  N N 114 
GLN NE2  N  N N 115 
GLN OXT  O  N N 116 
GLN H    H  N N 117 
GLN H2   H  N N 118 
GLN HA   H  N N 119 
GLN HB2  H  N N 120 
GLN HB3  H  N N 121 
GLN HG2  H  N N 122 
GLN HG3  H  N N 123 
GLN HE21 H  N N 124 
GLN HE22 H  N N 125 
GLN HXT  H  N N 126 
GLU N    N  N N 127 
GLU CA   C  N S 128 
GLU C    C  N N 129 
GLU O    O  N N 130 
GLU CB   C  N N 131 
GLU CG   C  N N 132 
GLU CD   C  N N 133 
GLU OE1  O  N N 134 
GLU OE2  O  N N 135 
GLU OXT  O  N N 136 
GLU H    H  N N 137 
GLU H2   H  N N 138 
GLU HA   H  N N 139 
GLU HB2  H  N N 140 
GLU HB3  H  N N 141 
GLU HG2  H  N N 142 
GLU HG3  H  N N 143 
GLU HE2  H  N N 144 
GLU HXT  H  N N 145 
GLY N    N  N N 146 
GLY CA   C  N N 147 
GLY C    C  N N 148 
GLY O    O  N N 149 
GLY OXT  O  N N 150 
GLY H    H  N N 151 
GLY H2   H  N N 152 
GLY HA2  H  N N 153 
GLY HA3  H  N N 154 
GLY HXT  H  N N 155 
HIS N    N  N N 156 
HIS CA   C  N S 157 
HIS C    C  N N 158 
HIS O    O  N N 159 
HIS CB   C  N N 160 
HIS CG   C  Y N 161 
HIS ND1  N  Y N 162 
HIS CD2  C  Y N 163 
HIS CE1  C  Y N 164 
HIS NE2  N  Y N 165 
HIS OXT  O  N N 166 
HIS H    H  N N 167 
HIS H2   H  N N 168 
HIS HA   H  N N 169 
HIS HB2  H  N N 170 
HIS HB3  H  N N 171 
HIS HD1  H  N N 172 
HIS HD2  H  N N 173 
HIS HE1  H  N N 174 
HIS HE2  H  N N 175 
HIS HXT  H  N N 176 
ILE N    N  N N 177 
ILE CA   C  N S 178 
ILE C    C  N N 179 
ILE O    O  N N 180 
ILE CB   C  N S 181 
ILE CG1  C  N N 182 
ILE CG2  C  N N 183 
ILE CD1  C  N N 184 
ILE OXT  O  N N 185 
ILE H    H  N N 186 
ILE H2   H  N N 187 
ILE HA   H  N N 188 
ILE HB   H  N N 189 
ILE HG12 H  N N 190 
ILE HG13 H  N N 191 
ILE HG21 H  N N 192 
ILE HG22 H  N N 193 
ILE HG23 H  N N 194 
ILE HD11 H  N N 195 
ILE HD12 H  N N 196 
ILE HD13 H  N N 197 
ILE HXT  H  N N 198 
LEU N    N  N N 199 
LEU CA   C  N S 200 
LEU C    C  N N 201 
LEU O    O  N N 202 
LEU CB   C  N N 203 
LEU CG   C  N N 204 
LEU CD1  C  N N 205 
LEU CD2  C  N N 206 
LEU OXT  O  N N 207 
LEU H    H  N N 208 
LEU H2   H  N N 209 
LEU HA   H  N N 210 
LEU HB2  H  N N 211 
LEU HB3  H  N N 212 
LEU HG   H  N N 213 
LEU HD11 H  N N 214 
LEU HD12 H  N N 215 
LEU HD13 H  N N 216 
LEU HD21 H  N N 217 
LEU HD22 H  N N 218 
LEU HD23 H  N N 219 
LEU HXT  H  N N 220 
LYS N    N  N N 221 
LYS CA   C  N S 222 
LYS C    C  N N 223 
LYS O    O  N N 224 
LYS CB   C  N N 225 
LYS CG   C  N N 226 
LYS CD   C  N N 227 
LYS CE   C  N N 228 
LYS NZ   N  N N 229 
LYS OXT  O  N N 230 
LYS H    H  N N 231 
LYS H2   H  N N 232 
LYS HA   H  N N 233 
LYS HB2  H  N N 234 
LYS HB3  H  N N 235 
LYS HG2  H  N N 236 
LYS HG3  H  N N 237 
LYS HD2  H  N N 238 
LYS HD3  H  N N 239 
LYS HE2  H  N N 240 
LYS HE3  H  N N 241 
LYS HZ1  H  N N 242 
LYS HZ2  H  N N 243 
LYS HZ3  H  N N 244 
LYS HXT  H  N N 245 
MET N    N  N N 246 
MET CA   C  N S 247 
MET C    C  N N 248 
MET O    O  N N 249 
MET CB   C  N N 250 
MET CG   C  N N 251 
MET SD   S  N N 252 
MET CE   C  N N 253 
MET OXT  O  N N 254 
MET H    H  N N 255 
MET H2   H  N N 256 
MET HA   H  N N 257 
MET HB2  H  N N 258 
MET HB3  H  N N 259 
MET HG2  H  N N 260 
MET HG3  H  N N 261 
MET HE1  H  N N 262 
MET HE2  H  N N 263 
MET HE3  H  N N 264 
MET HXT  H  N N 265 
PHE N    N  N N 266 
PHE CA   C  N S 267 
PHE C    C  N N 268 
PHE O    O  N N 269 
PHE CB   C  N N 270 
PHE CG   C  Y N 271 
PHE CD1  C  Y N 272 
PHE CD2  C  Y N 273 
PHE CE1  C  Y N 274 
PHE CE2  C  Y N 275 
PHE CZ   C  Y N 276 
PHE OXT  O  N N 277 
PHE H    H  N N 278 
PHE H2   H  N N 279 
PHE HA   H  N N 280 
PHE HB2  H  N N 281 
PHE HB3  H  N N 282 
PHE HD1  H  N N 283 
PHE HD2  H  N N 284 
PHE HE1  H  N N 285 
PHE HE2  H  N N 286 
PHE HZ   H  N N 287 
PHE HXT  H  N N 288 
PRO N    N  N N 289 
PRO CA   C  N S 290 
PRO C    C  N N 291 
PRO O    O  N N 292 
PRO CB   C  N N 293 
PRO CG   C  N N 294 
PRO CD   C  N N 295 
PRO OXT  O  N N 296 
PRO H    H  N N 297 
PRO HA   H  N N 298 
PRO HB2  H  N N 299 
PRO HB3  H  N N 300 
PRO HG2  H  N N 301 
PRO HG3  H  N N 302 
PRO HD2  H  N N 303 
PRO HD3  H  N N 304 
PRO HXT  H  N N 305 
SER N    N  N N 306 
SER CA   C  N S 307 
SER C    C  N N 308 
SER O    O  N N 309 
SER CB   C  N N 310 
SER OG   O  N N 311 
SER OXT  O  N N 312 
SER H    H  N N 313 
SER H2   H  N N 314 
SER HA   H  N N 315 
SER HB2  H  N N 316 
SER HB3  H  N N 317 
SER HG   H  N N 318 
SER HXT  H  N N 319 
THR N    N  N N 320 
THR CA   C  N S 321 
THR C    C  N N 322 
THR O    O  N N 323 
THR CB   C  N R 324 
THR OG1  O  N N 325 
THR CG2  C  N N 326 
THR OXT  O  N N 327 
THR H    H  N N 328 
THR H2   H  N N 329 
THR HA   H  N N 330 
THR HB   H  N N 331 
THR HG1  H  N N 332 
THR HG21 H  N N 333 
THR HG22 H  N N 334 
THR HG23 H  N N 335 
THR HXT  H  N N 336 
TRP N    N  N N 337 
TRP CA   C  N S 338 
TRP C    C  N N 339 
TRP O    O  N N 340 
TRP CB   C  N N 341 
TRP CG   C  Y N 342 
TRP CD1  C  Y N 343 
TRP CD2  C  Y N 344 
TRP NE1  N  Y N 345 
TRP CE2  C  Y N 346 
TRP CE3  C  Y N 347 
TRP CZ2  C  Y N 348 
TRP CZ3  C  Y N 349 
TRP CH2  C  Y N 350 
TRP OXT  O  N N 351 
TRP H    H  N N 352 
TRP H2   H  N N 353 
TRP HA   H  N N 354 
TRP HB2  H  N N 355 
TRP HB3  H  N N 356 
TRP HD1  H  N N 357 
TRP HE1  H  N N 358 
TRP HE3  H  N N 359 
TRP HZ2  H  N N 360 
TRP HZ3  H  N N 361 
TRP HH2  H  N N 362 
TRP HXT  H  N N 363 
TYR N    N  N N 364 
TYR CA   C  N S 365 
TYR C    C  N N 366 
TYR O    O  N N 367 
TYR CB   C  N N 368 
TYR CG   C  Y N 369 
TYR CD1  C  Y N 370 
TYR CD2  C  Y N 371 
TYR CE1  C  Y N 372 
TYR CE2  C  Y N 373 
TYR CZ   C  Y N 374 
TYR OH   O  N N 375 
TYR OXT  O  N N 376 
TYR H    H  N N 377 
TYR H2   H  N N 378 
TYR HA   H  N N 379 
TYR HB2  H  N N 380 
TYR HB3  H  N N 381 
TYR HD1  H  N N 382 
TYR HD2  H  N N 383 
TYR HE1  H  N N 384 
TYR HE2  H  N N 385 
TYR HH   H  N N 386 
TYR HXT  H  N N 387 
VAL N    N  N N 388 
VAL CA   C  N S 389 
VAL C    C  N N 390 
VAL O    O  N N 391 
VAL CB   C  N N 392 
VAL CG1  C  N N 393 
VAL CG2  C  N N 394 
VAL OXT  O  N N 395 
VAL H    H  N N 396 
VAL H2   H  N N 397 
VAL HA   H  N N 398 
VAL HB   H  N N 399 
VAL HG11 H  N N 400 
VAL HG12 H  N N 401 
VAL HG13 H  N N 402 
VAL HG21 H  N N 403 
VAL HG22 H  N N 404 
VAL HG23 H  N N 405 
VAL HXT  H  N N 406 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
3C4 O2  C    doub N N 1   
3C4 C   O1   sing N N 2   
3C4 C   CG   sing N N 3   
3C4 O1  HO1  sing N N 4   
3C4 CG  CA   sing N N 5   
3C4 CG  HG1  sing N N 6   
3C4 CG  HG2  sing N N 7   
3C4 CA  CD2  doub Y N 8   
3C4 CA  CD1  sing Y N 9   
3C4 CD2 CE2  sing Y N 10  
3C4 CD2 HD2  sing N N 11  
3C4 CE2 CZ   doub Y N 12  
3C4 CE2 HE2  sing N N 13  
3C4 CZ  OH   sing N N 14  
3C4 CZ  CE1  sing Y N 15  
3C4 OH  HOH  sing N N 16  
3C4 CL  CE1  sing N N 17  
3C4 CE1 CD1  doub Y N 18  
3C4 CD1 HD1  sing N N 19  
ALA N   CA   sing N N 20  
ALA N   H    sing N N 21  
ALA N   H2   sing N N 22  
ALA CA  C    sing N N 23  
ALA CA  CB   sing N N 24  
ALA CA  HA   sing N N 25  
ALA C   O    doub N N 26  
ALA C   OXT  sing N N 27  
ALA CB  HB1  sing N N 28  
ALA CB  HB2  sing N N 29  
ALA CB  HB3  sing N N 30  
ALA OXT HXT  sing N N 31  
ARG N   CA   sing N N 32  
ARG N   H    sing N N 33  
ARG N   H2   sing N N 34  
ARG CA  C    sing N N 35  
ARG CA  CB   sing N N 36  
ARG CA  HA   sing N N 37  
ARG C   O    doub N N 38  
ARG C   OXT  sing N N 39  
ARG CB  CG   sing N N 40  
ARG CB  HB2  sing N N 41  
ARG CB  HB3  sing N N 42  
ARG CG  CD   sing N N 43  
ARG CG  HG2  sing N N 44  
ARG CG  HG3  sing N N 45  
ARG CD  NE   sing N N 46  
ARG CD  HD2  sing N N 47  
ARG CD  HD3  sing N N 48  
ARG NE  CZ   sing N N 49  
ARG NE  HE   sing N N 50  
ARG CZ  NH1  sing N N 51  
ARG CZ  NH2  doub N N 52  
ARG NH1 HH11 sing N N 53  
ARG NH1 HH12 sing N N 54  
ARG NH2 HH21 sing N N 55  
ARG NH2 HH22 sing N N 56  
ARG OXT HXT  sing N N 57  
ASN N   CA   sing N N 58  
ASN N   H    sing N N 59  
ASN N   H2   sing N N 60  
ASN CA  C    sing N N 61  
ASN CA  CB   sing N N 62  
ASN CA  HA   sing N N 63  
ASN C   O    doub N N 64  
ASN C   OXT  sing N N 65  
ASN CB  CG   sing N N 66  
ASN CB  HB2  sing N N 67  
ASN CB  HB3  sing N N 68  
ASN CG  OD1  doub N N 69  
ASN CG  ND2  sing N N 70  
ASN ND2 HD21 sing N N 71  
ASN ND2 HD22 sing N N 72  
ASN OXT HXT  sing N N 73  
ASP N   CA   sing N N 74  
ASP N   H    sing N N 75  
ASP N   H2   sing N N 76  
ASP CA  C    sing N N 77  
ASP CA  CB   sing N N 78  
ASP CA  HA   sing N N 79  
ASP C   O    doub N N 80  
ASP C   OXT  sing N N 81  
ASP CB  CG   sing N N 82  
ASP CB  HB2  sing N N 83  
ASP CB  HB3  sing N N 84  
ASP CG  OD1  doub N N 85  
ASP CG  OD2  sing N N 86  
ASP OD2 HD2  sing N N 87  
ASP OXT HXT  sing N N 88  
CYS N   CA   sing N N 89  
CYS N   H    sing N N 90  
CYS N   H2   sing N N 91  
CYS CA  C    sing N N 92  
CYS CA  CB   sing N N 93  
CYS CA  HA   sing N N 94  
CYS C   O    doub N N 95  
CYS C   OXT  sing N N 96  
CYS CB  SG   sing N N 97  
CYS CB  HB2  sing N N 98  
CYS CB  HB3  sing N N 99  
CYS SG  HG   sing N N 100 
CYS OXT HXT  sing N N 101 
GLN N   CA   sing N N 102 
GLN N   H    sing N N 103 
GLN N   H2   sing N N 104 
GLN CA  C    sing N N 105 
GLN CA  CB   sing N N 106 
GLN CA  HA   sing N N 107 
GLN C   O    doub N N 108 
GLN C   OXT  sing N N 109 
GLN CB  CG   sing N N 110 
GLN CB  HB2  sing N N 111 
GLN CB  HB3  sing N N 112 
GLN CG  CD   sing N N 113 
GLN CG  HG2  sing N N 114 
GLN CG  HG3  sing N N 115 
GLN CD  OE1  doub N N 116 
GLN CD  NE2  sing N N 117 
GLN NE2 HE21 sing N N 118 
GLN NE2 HE22 sing N N 119 
GLN OXT HXT  sing N N 120 
GLU N   CA   sing N N 121 
GLU N   H    sing N N 122 
GLU N   H2   sing N N 123 
GLU CA  C    sing N N 124 
GLU CA  CB   sing N N 125 
GLU CA  HA   sing N N 126 
GLU C   O    doub N N 127 
GLU C   OXT  sing N N 128 
GLU CB  CG   sing N N 129 
GLU CB  HB2  sing N N 130 
GLU CB  HB3  sing N N 131 
GLU CG  CD   sing N N 132 
GLU CG  HG2  sing N N 133 
GLU CG  HG3  sing N N 134 
GLU CD  OE1  doub N N 135 
GLU CD  OE2  sing N N 136 
GLU OE2 HE2  sing N N 137 
GLU OXT HXT  sing N N 138 
GLY N   CA   sing N N 139 
GLY N   H    sing N N 140 
GLY N   H2   sing N N 141 
GLY CA  C    sing N N 142 
GLY CA  HA2  sing N N 143 
GLY CA  HA3  sing N N 144 
GLY C   O    doub N N 145 
GLY C   OXT  sing N N 146 
GLY OXT HXT  sing N N 147 
HIS N   CA   sing N N 148 
HIS N   H    sing N N 149 
HIS N   H2   sing N N 150 
HIS CA  C    sing N N 151 
HIS CA  CB   sing N N 152 
HIS CA  HA   sing N N 153 
HIS C   O    doub N N 154 
HIS C   OXT  sing N N 155 
HIS CB  CG   sing N N 156 
HIS CB  HB2  sing N N 157 
HIS CB  HB3  sing N N 158 
HIS CG  ND1  sing Y N 159 
HIS CG  CD2  doub Y N 160 
HIS ND1 CE1  doub Y N 161 
HIS ND1 HD1  sing N N 162 
HIS CD2 NE2  sing Y N 163 
HIS CD2 HD2  sing N N 164 
HIS CE1 NE2  sing Y N 165 
HIS CE1 HE1  sing N N 166 
HIS NE2 HE2  sing N N 167 
HIS OXT HXT  sing N N 168 
ILE N   CA   sing N N 169 
ILE N   H    sing N N 170 
ILE N   H2   sing N N 171 
ILE CA  C    sing N N 172 
ILE CA  CB   sing N N 173 
ILE CA  HA   sing N N 174 
ILE C   O    doub N N 175 
ILE C   OXT  sing N N 176 
ILE CB  CG1  sing N N 177 
ILE CB  CG2  sing N N 178 
ILE CB  HB   sing N N 179 
ILE CG1 CD1  sing N N 180 
ILE CG1 HG12 sing N N 181 
ILE CG1 HG13 sing N N 182 
ILE CG2 HG21 sing N N 183 
ILE CG2 HG22 sing N N 184 
ILE CG2 HG23 sing N N 185 
ILE CD1 HD11 sing N N 186 
ILE CD1 HD12 sing N N 187 
ILE CD1 HD13 sing N N 188 
ILE OXT HXT  sing N N 189 
LEU N   CA   sing N N 190 
LEU N   H    sing N N 191 
LEU N   H2   sing N N 192 
LEU CA  C    sing N N 193 
LEU CA  CB   sing N N 194 
LEU CA  HA   sing N N 195 
LEU C   O    doub N N 196 
LEU C   OXT  sing N N 197 
LEU CB  CG   sing N N 198 
LEU CB  HB2  sing N N 199 
LEU CB  HB3  sing N N 200 
LEU CG  CD1  sing N N 201 
LEU CG  CD2  sing N N 202 
LEU CG  HG   sing N N 203 
LEU CD1 HD11 sing N N 204 
LEU CD1 HD12 sing N N 205 
LEU CD1 HD13 sing N N 206 
LEU CD2 HD21 sing N N 207 
LEU CD2 HD22 sing N N 208 
LEU CD2 HD23 sing N N 209 
LEU OXT HXT  sing N N 210 
LYS N   CA   sing N N 211 
LYS N   H    sing N N 212 
LYS N   H2   sing N N 213 
LYS CA  C    sing N N 214 
LYS CA  CB   sing N N 215 
LYS CA  HA   sing N N 216 
LYS C   O    doub N N 217 
LYS C   OXT  sing N N 218 
LYS CB  CG   sing N N 219 
LYS CB  HB2  sing N N 220 
LYS CB  HB3  sing N N 221 
LYS CG  CD   sing N N 222 
LYS CG  HG2  sing N N 223 
LYS CG  HG3  sing N N 224 
LYS CD  CE   sing N N 225 
LYS CD  HD2  sing N N 226 
LYS CD  HD3  sing N N 227 
LYS CE  NZ   sing N N 228 
LYS CE  HE2  sing N N 229 
LYS CE  HE3  sing N N 230 
LYS NZ  HZ1  sing N N 231 
LYS NZ  HZ2  sing N N 232 
LYS NZ  HZ3  sing N N 233 
LYS OXT HXT  sing N N 234 
MET N   CA   sing N N 235 
MET N   H    sing N N 236 
MET N   H2   sing N N 237 
MET CA  C    sing N N 238 
MET CA  CB   sing N N 239 
MET CA  HA   sing N N 240 
MET C   O    doub N N 241 
MET C   OXT  sing N N 242 
MET CB  CG   sing N N 243 
MET CB  HB2  sing N N 244 
MET CB  HB3  sing N N 245 
MET CG  SD   sing N N 246 
MET CG  HG2  sing N N 247 
MET CG  HG3  sing N N 248 
MET SD  CE   sing N N 249 
MET CE  HE1  sing N N 250 
MET CE  HE2  sing N N 251 
MET CE  HE3  sing N N 252 
MET OXT HXT  sing N N 253 
PHE N   CA   sing N N 254 
PHE N   H    sing N N 255 
PHE N   H2   sing N N 256 
PHE CA  C    sing N N 257 
PHE CA  CB   sing N N 258 
PHE CA  HA   sing N N 259 
PHE C   O    doub N N 260 
PHE C   OXT  sing N N 261 
PHE CB  CG   sing N N 262 
PHE CB  HB2  sing N N 263 
PHE CB  HB3  sing N N 264 
PHE CG  CD1  doub Y N 265 
PHE CG  CD2  sing Y N 266 
PHE CD1 CE1  sing Y N 267 
PHE CD1 HD1  sing N N 268 
PHE CD2 CE2  doub Y N 269 
PHE CD2 HD2  sing N N 270 
PHE CE1 CZ   doub Y N 271 
PHE CE1 HE1  sing N N 272 
PHE CE2 CZ   sing Y N 273 
PHE CE2 HE2  sing N N 274 
PHE CZ  HZ   sing N N 275 
PHE OXT HXT  sing N N 276 
PRO N   CA   sing N N 277 
PRO N   CD   sing N N 278 
PRO N   H    sing N N 279 
PRO CA  C    sing N N 280 
PRO CA  CB   sing N N 281 
PRO CA  HA   sing N N 282 
PRO C   O    doub N N 283 
PRO C   OXT  sing N N 284 
PRO CB  CG   sing N N 285 
PRO CB  HB2  sing N N 286 
PRO CB  HB3  sing N N 287 
PRO CG  CD   sing N N 288 
PRO CG  HG2  sing N N 289 
PRO CG  HG3  sing N N 290 
PRO CD  HD2  sing N N 291 
PRO CD  HD3  sing N N 292 
PRO OXT HXT  sing N N 293 
SER N   CA   sing N N 294 
SER N   H    sing N N 295 
SER N   H2   sing N N 296 
SER CA  C    sing N N 297 
SER CA  CB   sing N N 298 
SER CA  HA   sing N N 299 
SER C   O    doub N N 300 
SER C   OXT  sing N N 301 
SER CB  OG   sing N N 302 
SER CB  HB2  sing N N 303 
SER CB  HB3  sing N N 304 
SER OG  HG   sing N N 305 
SER OXT HXT  sing N N 306 
THR N   CA   sing N N 307 
THR N   H    sing N N 308 
THR N   H2   sing N N 309 
THR CA  C    sing N N 310 
THR CA  CB   sing N N 311 
THR CA  HA   sing N N 312 
THR C   O    doub N N 313 
THR C   OXT  sing N N 314 
THR CB  OG1  sing N N 315 
THR CB  CG2  sing N N 316 
THR CB  HB   sing N N 317 
THR OG1 HG1  sing N N 318 
THR CG2 HG21 sing N N 319 
THR CG2 HG22 sing N N 320 
THR CG2 HG23 sing N N 321 
THR OXT HXT  sing N N 322 
TRP N   CA   sing N N 323 
TRP N   H    sing N N 324 
TRP N   H2   sing N N 325 
TRP CA  C    sing N N 326 
TRP CA  CB   sing N N 327 
TRP CA  HA   sing N N 328 
TRP C   O    doub N N 329 
TRP C   OXT  sing N N 330 
TRP CB  CG   sing N N 331 
TRP CB  HB2  sing N N 332 
TRP CB  HB3  sing N N 333 
TRP CG  CD1  doub Y N 334 
TRP CG  CD2  sing Y N 335 
TRP CD1 NE1  sing Y N 336 
TRP CD1 HD1  sing N N 337 
TRP CD2 CE2  doub Y N 338 
TRP CD2 CE3  sing Y N 339 
TRP NE1 CE2  sing Y N 340 
TRP NE1 HE1  sing N N 341 
TRP CE2 CZ2  sing Y N 342 
TRP CE3 CZ3  doub Y N 343 
TRP CE3 HE3  sing N N 344 
TRP CZ2 CH2  doub Y N 345 
TRP CZ2 HZ2  sing N N 346 
TRP CZ3 CH2  sing Y N 347 
TRP CZ3 HZ3  sing N N 348 
TRP CH2 HH2  sing N N 349 
TRP OXT HXT  sing N N 350 
TYR N   CA   sing N N 351 
TYR N   H    sing N N 352 
TYR N   H2   sing N N 353 
TYR CA  C    sing N N 354 
TYR CA  CB   sing N N 355 
TYR CA  HA   sing N N 356 
TYR C   O    doub N N 357 
TYR C   OXT  sing N N 358 
TYR CB  CG   sing N N 359 
TYR CB  HB2  sing N N 360 
TYR CB  HB3  sing N N 361 
TYR CG  CD1  doub Y N 362 
TYR CG  CD2  sing Y N 363 
TYR CD1 CE1  sing Y N 364 
TYR CD1 HD1  sing N N 365 
TYR CD2 CE2  doub Y N 366 
TYR CD2 HD2  sing N N 367 
TYR CE1 CZ   doub Y N 368 
TYR CE1 HE1  sing N N 369 
TYR CE2 CZ   sing Y N 370 
TYR CE2 HE2  sing N N 371 
TYR CZ  OH   sing N N 372 
TYR OH  HH   sing N N 373 
TYR OXT HXT  sing N N 374 
VAL N   CA   sing N N 375 
VAL N   H    sing N N 376 
VAL N   H2   sing N N 377 
VAL CA  C    sing N N 378 
VAL CA  CB   sing N N 379 
VAL CA  HA   sing N N 380 
VAL C   O    doub N N 381 
VAL C   OXT  sing N N 382 
VAL CB  CG1  sing N N 383 
VAL CB  CG2  sing N N 384 
VAL CB  HB   sing N N 385 
VAL CG1 HG11 sing N N 386 
VAL CG1 HG12 sing N N 387 
VAL CG1 HG13 sing N N 388 
VAL CG2 HG21 sing N N 389 
VAL CG2 HG22 sing N N 390 
VAL CG2 HG23 sing N N 391 
VAL OXT HXT  sing N N 392 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2025-02-27 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           9M2H 
_em_admin.last_update        2025-06-11 
_em_admin.map_release_date   2025-05-28 
_em_admin.title              'Structure of the auxin importer AUX1 in Arabidopsis thaliana in the CHPAA-bound state' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     NONE 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          3702 
_em_entity_assembly_naturalsource.organism             'Arabidopsis thaliana' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          7108 
_em_entity_assembly_recombinant.organism             'Spodoptera frugiperda' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
_em_software.reference_DOI 
'MODEL REFINEMENT'              ? 1  ? ? ? PHENIX 1.13_2998: ? 
'IMAGE ACQUISITION'             ? 2  1 1 1 ?      ?          ? 
'PARTICLE SELECTION'            ? 3  1 1 1 ?      ?          ? 
'VOLUME SELECTION'              ? 4  1 1 1 ?      ?          ? 
CLASSIFICATION                  ? 5  1 1 1 ?      ?          ? 
MASKING                         ? 6  1 1 1 ?      ?          ? 
RECONSTRUCTION                  ? 7  1 1 1 ?      ?          ? 
'INITIAL EULER ASSIGNMENT'      ? 8  1 1 1 ?      ?          ? 
'FINAL EULER ASSIGNMENT'        ? 9  1 1 1 ?      ?          ? 
'CTF CORRECTION'                ? 10 1 1 1 ?      ?          ? 
'LAYERLINE INDEXING'            ? 11 1 1 1 ?      ?          ? 
'DIFFRACTION INDEXING'          ? 12 1 1 1 ?      ?          ? 
'MODEL FITTING'                 ? 13 1 1 1 ?      ?          ? 
'SERIES ALIGNMENT'              ? 14 1 1 1 ?      ?          ? 
'MOLECULAR REPLACEMENT'         ? 15 1 1 1 ?      ?          ? 
'LATTICE DISTORTION CORRECTION' ? 16 1 1 1 ?      ?          ? 
'SYMMETRY DETERMINATION'        ? 17 1 1 1 ?      ?          ? 
'CRYSTALLOGRAPHY MERGING'       ? 18 1 1 1 ?      ?          ? 
OTHER                           ? 19 1 1 1 ?      ?          ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Science Foundation (NSF, China)' China 32322041 1 
'National Science Foundation (NSF, China)' China 32321001 2 
'National Science Foundation (NSF, China)' China 31900885 3 
# 
_atom_sites.entry_id                    9M2H 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
CL 
N  
O  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . SER A 1 39  ? 134.924 132.336 130.789 1.00 72.13 ? 39  SER A N   1 
ATOM   2    C  CA  . SER A 1 39  ? 133.656 133.002 131.055 1.00 72.13 ? 39  SER A CA  1 
ATOM   3    C  C   . SER A 1 39  ? 132.887 132.277 132.148 1.00 72.13 ? 39  SER A C   1 
ATOM   4    O  O   . SER A 1 39  ? 133.068 132.559 133.320 1.00 72.13 ? 39  SER A O   1 
ATOM   5    C  CB  . SER A 1 39  ? 132.828 133.094 129.792 1.00 72.13 ? 39  SER A CB  1 
ATOM   6    N  N   . ASN A 1 40  ? 132.017 131.351 131.772 1.00 76.30 ? 40  ASN A N   1 
ATOM   7    C  CA  . ASN A 1 40  ? 131.229 130.611 132.744 1.00 76.30 ? 40  ASN A CA  1 
ATOM   8    C  C   . ASN A 1 40  ? 132.005 129.364 133.154 1.00 76.30 ? 40  ASN A C   1 
ATOM   9    O  O   . ASN A 1 40  ? 132.781 128.824 132.367 1.00 76.30 ? 40  ASN A O   1 
ATOM   10   C  CB  . ASN A 1 40  ? 129.863 130.262 132.153 1.00 76.30 ? 40  ASN A CB  1 
ATOM   11   C  CG  . ASN A 1 40  ? 128.839 129.949 133.213 1.00 76.30 ? 40  ASN A CG  1 
ATOM   12   O  OD1 . ASN A 1 40  ? 129.160 129.863 134.394 1.00 76.30 ? 40  ASN A OD1 1 
ATOM   13   N  ND2 . ASN A 1 40  ? 127.585 129.816 132.803 1.00 76.30 ? 40  ASN A ND2 1 
ATOM   14   N  N   . PHE A 1 41  ? 131.886 128.984 134.424 1.00 75.31 ? 41  PHE A N   1 
ATOM   15   C  CA  . PHE A 1 41  ? 132.763 127.998 135.065 1.00 75.31 ? 41  PHE A CA  1 
ATOM   16   C  C   . PHE A 1 41  ? 131.993 127.075 136.014 1.00 75.31 ? 41  PHE A C   1 
ATOM   17   O  O   . PHE A 1 41  ? 132.288 126.995 137.208 1.00 75.31 ? 41  PHE A O   1 
ATOM   18   C  CB  . PHE A 1 41  ? 133.918 128.694 135.762 1.00 75.31 ? 41  PHE A CB  1 
ATOM   19   C  CG  . PHE A 1 41  ? 135.034 129.075 134.839 1.00 75.31 ? 41  PHE A CG  1 
ATOM   20   C  CD1 . PHE A 1 41  ? 136.070 128.189 134.585 1.00 75.31 ? 41  PHE A CD1 1 
ATOM   21   C  CD2 . PHE A 1 41  ? 135.043 130.306 134.209 1.00 75.31 ? 41  PHE A CD2 1 
ATOM   22   C  CE1 . PHE A 1 41  ? 137.104 128.540 133.739 1.00 75.31 ? 41  PHE A CE1 1 
ATOM   23   C  CE2 . PHE A 1 41  ? 136.063 130.660 133.350 1.00 75.31 ? 41  PHE A CE2 1 
ATOM   24   C  CZ  . PHE A 1 41  ? 137.092 129.777 133.117 1.00 75.31 ? 41  PHE A CZ  1 
ATOM   25   N  N   . LEU A 1 42  ? 130.986 126.365 135.483 1.00 84.78 ? 42  LEU A N   1 
ATOM   26   C  CA  . LEU A 1 42  ? 130.041 125.542 136.251 1.00 84.78 ? 42  LEU A CA  1 
ATOM   27   C  C   . LEU A 1 42  ? 130.740 124.615 137.252 1.00 84.78 ? 42  LEU A C   1 
ATOM   28   O  O   . LEU A 1 42  ? 130.157 124.331 138.305 1.00 84.78 ? 42  LEU A O   1 
ATOM   29   C  CB  . LEU A 1 42  ? 129.064 124.840 135.300 1.00 84.78 ? 42  LEU A CB  1 
ATOM   30   C  CG  . LEU A 1 42  ? 127.717 125.461 134.954 1.00 84.78 ? 42  LEU A CG  1 
ATOM   31   C  CD1 . LEU A 1 42  ? 126.907 125.583 136.218 1.00 84.78 ? 42  LEU A CD1 1 
ATOM   32   C  CD2 . LEU A 1 42  ? 127.858 126.792 134.294 1.00 84.78 ? 42  LEU A CD2 1 
ATOM   33   N  N   . TRP A 1 43  ? 131.939 124.112 136.957 1.00 83.76 ? 43  TRP A N   1 
ATOM   34   C  CA  . TRP A 1 43  ? 132.558 123.105 137.814 1.00 83.76 ? 43  TRP A CA  1 
ATOM   35   C  C   . TRP A 1 43  ? 132.580 123.324 139.325 1.00 83.76 ? 43  TRP A C   1 
ATOM   36   O  O   . TRP A 1 43  ? 132.292 122.402 140.098 1.00 83.76 ? 43  TRP A O   1 
ATOM   37   C  CB  . TRP A 1 43  ? 133.968 122.837 137.282 1.00 83.76 ? 43  TRP A CB  1 
ATOM   38   C  CG  . TRP A 1 43  ? 133.990 122.352 135.859 1.00 83.76 ? 43  TRP A CG  1 
ATOM   39   C  CD1 . TRP A 1 43  ? 134.264 123.089 134.743 1.00 83.76 ? 43  TRP A CD1 1 
ATOM   40   C  CD2 . TRP A 1 43  ? 133.705 121.026 135.403 1.00 83.76 ? 43  TRP A CD2 1 
ATOM   41   N  NE1 . TRP A 1 43  ? 134.174 122.302 133.624 1.00 83.76 ? 43  TRP A NE1 1 
ATOM   42   C  CE2 . TRP A 1 43  ? 133.834 121.031 134.002 1.00 83.76 ? 43  TRP A CE2 1 
ATOM   43   C  CE3 . TRP A 1 43  ? 133.357 119.834 136.044 1.00 83.76 ? 43  TRP A CE3 1 
ATOM   44   C  CZ2 . TRP A 1 43  ? 133.626 119.891 133.231 1.00 83.76 ? 43  TRP A CZ2 1 
ATOM   45   C  CZ3 . TRP A 1 43  ? 133.152 118.704 135.278 1.00 83.76 ? 43  TRP A CZ3 1 
ATOM   46   C  CH2 . TRP A 1 43  ? 133.288 118.740 133.886 1.00 83.76 ? 43  TRP A CH2 1 
ATOM   47   N  N   . HIS A 1 44  ? 132.961 124.536 139.763 1.00 78.10 ? 44  HIS A N   1 
ATOM   48   C  CA  . HIS A 1 44  ? 133.222 124.918 141.164 1.00 78.10 ? 44  HIS A CA  1 
ATOM   49   C  C   . HIS A 1 44  ? 134.300 124.072 141.848 1.00 78.10 ? 44  HIS A C   1 
ATOM   50   O  O   . HIS A 1 44  ? 134.424 124.111 143.076 1.00 78.10 ? 44  HIS A O   1 
ATOM   51   C  CB  . HIS A 1 44  ? 131.952 124.899 142.031 1.00 78.10 ? 44  HIS A CB  1 
ATOM   52   C  CG  . HIS A 1 44  ? 131.060 126.083 141.849 1.00 78.10 ? 44  HIS A CG  1 
ATOM   53   N  ND1 . HIS A 1 44  ? 131.344 127.315 142.397 1.00 78.10 ? 44  HIS A ND1 1 
ATOM   54   C  CD2 . HIS A 1 44  ? 129.873 126.217 141.215 1.00 78.10 ? 44  HIS A CD2 1 
ATOM   55   C  CE1 . HIS A 1 44  ? 130.378 128.162 142.093 1.00 78.10 ? 44  HIS A CE1 1 
ATOM   56   N  NE2 . HIS A 1 44  ? 129.473 127.521 141.376 1.00 78.10 ? 44  HIS A NE2 1 
ATOM   57   N  N   . GLY A 1 45  ? 135.103 123.324 141.095 1.00 72.43 ? 45  GLY A N   1 
ATOM   58   C  CA  . GLY A 1 45  ? 136.118 122.461 141.669 1.00 72.43 ? 45  GLY A CA  1 
ATOM   59   C  C   . GLY A 1 45  ? 137.383 122.473 140.843 1.00 72.43 ? 45  GLY A C   1 
ATOM   60   O  O   . GLY A 1 45  ? 138.140 121.498 140.836 1.00 72.43 ? 45  GLY A O   1 
ATOM   61   N  N   . GLY A 1 46  ? 137.609 123.585 140.147 1.00 68.14 ? 46  GLY A N   1 
ATOM   62   C  CA  . GLY A 1 46  ? 138.606 123.618 139.091 1.00 68.14 ? 46  GLY A CA  1 
ATOM   63   C  C   . GLY A 1 46  ? 140.025 123.549 139.624 1.00 68.14 ? 46  GLY A C   1 
ATOM   64   O  O   . GLY A 1 46  ? 140.385 124.214 140.594 1.00 68.14 ? 46  GLY A O   1 
ATOM   65   N  N   . SER A 1 47  ? 140.840 122.746 138.949 1.00 63.98 ? 47  SER A N   1 
ATOM   66   C  CA  . SER A 1 47  ? 142.167 122.403 139.419 1.00 63.98 ? 47  SER A CA  1 
ATOM   67   C  C   . SER A 1 47  ? 143.141 123.537 139.128 1.00 63.98 ? 47  SER A C   1 
ATOM   68   O  O   . SER A 1 47  ? 142.789 124.564 138.550 1.00 63.98 ? 47  SER A O   1 
ATOM   69   C  CB  . SER A 1 47  ? 142.630 121.105 138.768 1.00 63.98 ? 47  SER A CB  1 
ATOM   70   O  OG  . SER A 1 47  ? 143.914 120.738 139.231 1.00 63.98 ? 47  SER A OG  1 
ATOM   71   N  N   . VAL A 1 48  ? 144.402 123.513 139.528 1.00 63.01 ? 48  VAL A N   1 
ATOM   72   C  CA  . VAL A 1 48  ? 145.364 124.583 139.167 1.00 63.01 ? 48  VAL A CA  1 
ATOM   73   C  C   . VAL A 1 48  ? 145.736 124.705 137.704 1.00 63.01 ? 48  VAL A C   1 
ATOM   74   O  O   . VAL A 1 48  ? 145.696 125.804 137.103 1.00 63.01 ? 48  VAL A O   1 
ATOM   75   C  CB  . VAL A 1 48  ? 146.629 124.275 139.843 1.00 63.01 ? 48  VAL A CB  1 
ATOM   76   C  CG1 . VAL A 1 48  ? 147.761 125.168 139.380 1.00 63.01 ? 48  VAL A CG1 1 
ATOM   77   C  CG2 . VAL A 1 48  ? 146.434 124.363 141.341 1.00 63.01 ? 48  VAL A CG2 1 
ATOM   78   N  N   . TRP A 1 49  ? 146.116 123.612 137.076 1.00 60.95 ? 49  TRP A N   1 
ATOM   79   C  CA  . TRP A 1 49  ? 146.334 123.601 135.624 1.00 60.95 ? 49  TRP A CA  1 
ATOM   80   C  C   . TRP A 1 49  ? 145.150 124.104 134.797 1.00 60.95 ? 49  TRP A C   1 
ATOM   81   O  O   . TRP A 1 49  ? 145.348 124.841 133.826 1.00 60.95 ? 49  TRP A O   1 
ATOM   82   C  CB  . TRP A 1 49  ? 146.552 122.197 135.138 1.00 60.95 ? 49  TRP A CB  1 
ATOM   83   C  CG  . TRP A 1 49  ? 147.713 121.454 135.523 1.00 60.95 ? 49  TRP A CG  1 
ATOM   84   C  CD1 . TRP A 1 49  ? 147.866 120.707 136.633 1.00 60.95 ? 49  TRP A CD1 1 
ATOM   85   C  CD2 . TRP A 1 49  ? 148.857 121.237 134.725 1.00 60.95 ? 49  TRP A CD2 1 
ATOM   86   N  NE1 . TRP A 1 49  ? 149.064 120.066 136.602 1.00 60.95 ? 49  TRP A NE1 1 
ATOM   87   C  CE2 . TRP A 1 49  ? 149.696 120.380 135.431 1.00 60.95 ? 49  TRP A CE2 1 
ATOM   88   C  CE3 . TRP A 1 49  ? 149.267 121.712 133.489 1.00 60.95 ? 49  TRP A CE3 1 
ATOM   89   C  CZ2 . TRP A 1 49  ? 150.922 119.984 134.948 1.00 60.95 ? 49  TRP A CZ2 1 
ATOM   90   C  CZ3 . TRP A 1 49  ? 150.477 121.324 133.012 1.00 60.95 ? 49  TRP A CZ3 1 
ATOM   91   C  CH2 . TRP A 1 49  ? 151.298 120.472 133.738 1.00 60.95 ? 49  TRP A CH2 1 
ATOM   92   N  N   . ASP A 1 50  ? 143.950 123.667 135.093 1.00 62.59 ? 50  ASP A N   1 
ATOM   93   C  CA  . ASP A 1 50  ? 142.829 124.192 134.385 1.00 62.59 ? 50  ASP A CA  1 
ATOM   94   C  C   . ASP A 1 50  ? 142.939 125.645 134.348 1.00 62.59 ? 50  ASP A C   1 
ATOM   95   O  O   . ASP A 1 50  ? 142.962 126.241 133.291 1.00 62.59 ? 50  ASP A O   1 
ATOM   96   C  CB  . ASP A 1 50  ? 141.581 123.926 135.143 1.00 62.59 ? 50  ASP A CB  1 
ATOM   97   C  CG  . ASP A 1 50  ? 140.355 123.843 134.266 1.00 62.59 ? 50  ASP A CG  1 
ATOM   98   O  OD1 . ASP A 1 50  ? 140.241 124.591 133.281 1.00 62.59 ? 50  ASP A OD1 1 
ATOM   99   O  OD2 . ASP A 1 50  ? 139.478 123.022 134.583 1.00 62.59 ? 50  ASP A OD2 1 
ATOM   100  N  N   . ALA A 1 51  ? 142.996 126.276 135.483 1.00 58.68 ? 51  ALA A N   1 
ATOM   101  C  CA  . ALA A 1 51  ? 142.979 127.706 135.453 1.00 58.68 ? 51  ALA A CA  1 
ATOM   102  C  C   . ALA A 1 51  ? 144.212 128.317 134.794 1.00 58.68 ? 51  ALA A C   1 
ATOM   103  O  O   . ALA A 1 51  ? 144.036 129.312 134.117 1.00 58.68 ? 51  ALA A O   1 
ATOM   104  C  CB  . ALA A 1 51  ? 142.729 128.270 136.796 1.00 58.68 ? 51  ALA A CB  1 
ATOM   105  N  N   . TRP A 1 52  ? 145.418 127.739 134.776 1.00 53.54 ? 52  TRP A N   1 
ATOM   106  C  CA  . TRP A 1 52  ? 146.539 128.315 134.009 1.00 53.54 ? 52  TRP A CA  1 
ATOM   107  C  C   . TRP A 1 52  ? 146.082 128.476 132.636 1.00 53.54 ? 52  TRP A C   1 
ATOM   108  O  O   . TRP A 1 52  ? 145.920 129.591 132.084 1.00 53.54 ? 52  TRP A O   1 
ATOM   109  C  CB  . TRP A 1 52  ? 147.663 127.342 133.936 1.00 53.54 ? 52  TRP A CB  1 
ATOM   110  C  CG  . TRP A 1 52  ? 148.874 127.809 133.249 1.00 53.54 ? 52  TRP A CG  1 
ATOM   111  C  CD1 . TRP A 1 52  ? 149.679 128.817 133.628 1.00 53.54 ? 52  TRP A CD1 1 
ATOM   112  C  CD2 . TRP A 1 52  ? 149.442 127.271 132.064 1.00 53.54 ? 52  TRP A CD2 1 
ATOM   113  N  NE1 . TRP A 1 52  ? 150.708 128.958 132.748 1.00 53.54 ? 52  TRP A NE1 1 
ATOM   114  C  CE2 . TRP A 1 52  ? 150.585 128.012 131.777 1.00 53.54 ? 52  TRP A CE2 1 
ATOM   115  C  CE3 . TRP A 1 52  ? 149.089 126.238 131.214 1.00 53.54 ? 52  TRP A CE3 1 
ATOM   116  C  CZ2 . TRP A 1 52  ? 151.371 127.760 130.689 1.00 53.54 ? 52  TRP A CZ2 1 
ATOM   117  C  CZ3 . TRP A 1 52  ? 149.868 125.988 130.132 1.00 53.54 ? 52  TRP A CZ3 1 
ATOM   118  C  CH2 . TRP A 1 52  ? 150.998 126.743 129.875 1.00 53.54 ? 52  TRP A CH2 1 
ATOM   119  N  N   . PHE A 1 53  ? 145.851 127.366 132.038 1.00 55.66 ? 53  PHE A N   1 
ATOM   120  C  CA  . PHE A 1 53  ? 145.305 127.358 130.741 1.00 55.66 ? 53  PHE A CA  1 
ATOM   121  C  C   . PHE A 1 53  ? 144.263 128.385 130.466 1.00 55.66 ? 53  PHE A C   1 
ATOM   122  O  O   . PHE A 1 53  ? 144.430 129.073 129.548 1.00 55.66 ? 53  PHE A O   1 
ATOM   123  C  CB  . PHE A 1 53  ? 144.643 125.997 130.537 1.00 55.66 ? 53  PHE A CB  1 
ATOM   124  C  CG  . PHE A 1 53  ? 145.591 124.896 130.097 1.00 55.66 ? 53  PHE A CG  1 
ATOM   125  C  CD1 . PHE A 1 53  ? 145.611 124.459 128.792 1.00 55.66 ? 53  PHE A CD1 1 
ATOM   126  C  CD2 . PHE A 1 53  ? 146.437 124.292 130.992 1.00 55.66 ? 53  PHE A CD2 1 
ATOM   127  C  CE1 . PHE A 1 53  ? 146.469 123.464 128.393 1.00 55.66 ? 53  PHE A CE1 1 
ATOM   128  C  CE2 . PHE A 1 53  ? 147.295 123.296 130.601 1.00 55.66 ? 53  PHE A CE2 1 
ATOM   129  C  CZ  . PHE A 1 53  ? 147.312 122.884 129.299 1.00 55.66 ? 53  PHE A CZ  1 
ATOM   130  N  N   . SER A 1 54  ? 143.163 128.448 131.171 1.00 55.85 ? 54  SER A N   1 
ATOM   131  C  CA  . SER A 1 54  ? 142.092 129.360 130.907 1.00 55.85 ? 54  SER A CA  1 
ATOM   132  C  C   . SER A 1 54  ? 142.555 130.790 130.886 1.00 55.85 ? 54  SER A C   1 
ATOM   133  O  O   . SER A 1 54  ? 142.359 131.428 129.895 1.00 55.85 ? 54  SER A O   1 
ATOM   134  C  CB  . SER A 1 54  ? 141.087 129.150 131.963 1.00 55.85 ? 54  SER A CB  1 
ATOM   135  O  OG  . SER A 1 54  ? 140.028 130.037 131.793 1.00 55.85 ? 54  SER A OG  1 
ATOM   136  N  N   . CYS A 1 55  ? 143.228 131.312 131.915 1.00 53.80 ? 55  CYS A N   1 
ATOM   137  C  CA  . CYS A 1 55  ? 143.796 132.671 131.944 1.00 53.80 ? 55  CYS A CA  1 
ATOM   138  C  C   . CYS A 1 55  ? 144.733 132.939 130.821 1.00 53.80 ? 55  CYS A C   1 
ATOM   139  O  O   . CYS A 1 55  ? 144.855 134.063 130.416 1.00 53.80 ? 55  CYS A O   1 
ATOM   140  C  CB  . CYS A 1 55  ? 144.586 132.894 133.187 1.00 53.80 ? 55  CYS A CB  1 
ATOM   141  S  SG  . CYS A 1 55  ? 143.602 133.149 134.643 1.00 53.80 ? 55  CYS A SG  1 
ATOM   142  N  N   . ALA A 1 56  ? 145.465 131.952 130.327 1.00 54.12 ? 56  ALA A N   1 
ATOM   143  C  CA  . ALA A 1 56  ? 146.285 132.192 129.135 1.00 54.12 ? 56  ALA A CA  1 
ATOM   144  C  C   . ALA A 1 56  ? 145.516 132.208 127.852 1.00 54.12 ? 56  ALA A C   1 
ATOM   145  O  O   . ALA A 1 56  ? 145.715 133.102 127.075 1.00 54.12 ? 56  ALA A O   1 
ATOM   146  C  CB  . ALA A 1 56  ? 147.357 131.159 129.018 1.00 54.12 ? 56  ALA A CB  1 
ATOM   147  N  N   . SER A 1 57  ? 144.615 131.276 127.622 1.00 56.95 ? 57  SER A N   1 
ATOM   148  C  CA  . SER A 1 57  ? 143.965 131.156 126.329 1.00 56.95 ? 57  SER A CA  1 
ATOM   149  C  C   . SER A 1 57  ? 143.198 132.327 125.998 1.00 56.95 ? 57  SER A C   1 
ATOM   150  O  O   . SER A 1 57  ? 142.842 132.572 124.835 1.00 56.95 ? 57  SER A O   1 
ATOM   151  C  CB  . SER A 1 57  ? 143.128 129.943 126.375 1.00 56.95 ? 57  SER A CB  1 
ATOM   152  O  OG  . SER A 1 57  ? 142.880 129.478 125.080 1.00 56.95 ? 57  SER A OG  1 
ATOM   153  N  N   . ASN A 1 58  ? 142.987 133.148 126.982 1.00 57.65 ? 58  ASN A N   1 
ATOM   154  C  CA  . ASN A 1 58  ? 142.051 134.222 126.713 1.00 57.65 ? 58  ASN A CA  1 
ATOM   155  C  C   . ASN A 1 58  ? 142.564 135.634 126.504 1.00 57.65 ? 58  ASN A C   1 
ATOM   156  O  O   . ASN A 1 58  ? 141.792 136.512 126.117 1.00 57.65 ? 58  ASN A O   1 
ATOM   157  C  CB  . ASN A 1 58  ? 141.075 134.014 127.874 1.00 57.65 ? 58  ASN A CB  1 
ATOM   158  C  CG  . ASN A 1 58  ? 139.664 134.398 127.520 1.00 57.65 ? 58  ASN A CG  1 
ATOM   159  O  OD1 . ASN A 1 58  ? 139.388 134.864 126.416 1.00 57.65 ? 58  ASN A OD1 1 
ATOM   160  N  ND2 . ASN A 1 58  ? 138.749 134.174 128.443 1.00 57.65 ? 58  ASN A ND2 1 
ATOM   161  N  N   . GLN A 1 59  ? 143.839 135.883 126.796 1.00 54.08 ? 59  GLN A N   1 
ATOM   162  C  CA  . GLN A 1 59  ? 144.422 137.184 126.495 1.00 54.08 ? 59  GLN A CA  1 
ATOM   163  C  C   . GLN A 1 59  ? 144.799 137.469 125.054 1.00 54.08 ? 59  GLN A C   1 
ATOM   164  O  O   . GLN A 1 59  ? 144.619 138.588 124.562 1.00 54.08 ? 59  GLN A O   1 
ATOM   165  C  CB  . GLN A 1 59  ? 145.636 137.362 127.390 1.00 54.08 ? 59  GLN A CB  1 
ATOM   166  C  CG  . GLN A 1 59  ? 145.323 137.306 128.835 1.00 54.08 ? 59  GLN A CG  1 
ATOM   167  C  CD  . GLN A 1 59  ? 146.563 137.398 129.653 1.00 54.08 ? 59  GLN A CD  1 
ATOM   168  O  OE1 . GLN A 1 59  ? 147.662 137.481 129.118 1.00 54.08 ? 59  GLN A OE1 1 
ATOM   169  N  NE2 . GLN A 1 59  ? 146.409 137.360 130.957 1.00 54.08 ? 59  GLN A NE2 1 
ATOM   170  N  N   . VAL A 1 60  ? 145.363 136.480 124.373 1.00 51.81 ? 60  VAL A N   1 
ATOM   171  C  CA  . VAL A 1 60  ? 145.785 136.622 122.990 1.00 51.81 ? 60  VAL A CA  1 
ATOM   172  C  C   . VAL A 1 60  ? 144.873 135.770 122.127 1.00 51.81 ? 60  VAL A C   1 
ATOM   173  O  O   . VAL A 1 60  ? 144.900 134.537 122.207 1.00 51.81 ? 60  VAL A O   1 
ATOM   174  C  CB  . VAL A 1 60  ? 147.258 136.241 122.810 1.00 51.81 ? 60  VAL A CB  1 
ATOM   175  C  CG1 . VAL A 1 60  ? 147.608 136.184 121.354 1.00 51.81 ? 60  VAL A CG1 1 
ATOM   176  C  CG2 . VAL A 1 60  ? 148.105 137.278 123.476 1.00 51.81 ? 60  VAL A CG2 1 
ATOM   177  N  N   . ALA A 1 61  ? 144.032 136.434 121.333 1.00 48.62 ? 61  ALA A N   1 
ATOM   178  C  CA  . ALA A 1 61  ? 143.192 135.759 120.349 1.00 48.62 ? 61  ALA A CA  1 
ATOM   179  C  C   . ALA A 1 61  ? 143.556 136.214 118.944 1.00 48.62 ? 61  ALA A C   1 
ATOM   180  O  O   . ALA A 1 61  ? 143.884 135.380 118.104 1.00 48.62 ? 61  ALA A O   1 
ATOM   181  C  CB  . ALA A 1 61  ? 141.716 136.008 120.652 1.00 48.62 ? 61  ALA A CB  1 
ATOM   182  N  N   . GLN A 1 62  ? 143.657 137.521 118.673 1.00 45.30 ? 62  GLN A N   1 
ATOM   183  C  CA  . GLN A 1 62  ? 144.081 138.056 117.349 1.00 45.30 ? 62  GLN A CA  1 
ATOM   184  C  C   . GLN A 1 62  ? 145.248 138.894 117.451 1.00 45.30 ? 62  GLN A C   1 
ATOM   185  O  O   . GLN A 1 62  ? 145.922 139.087 116.500 1.00 45.30 ? 62  GLN A O   1 
ATOM   186  C  CB  . GLN A 1 62  ? 143.092 139.002 116.655 1.00 45.30 ? 62  GLN A CB  1 
ATOM   187  C  CG  . GLN A 1 62  ? 142.818 140.292 117.363 1.00 45.30 ? 62  GLN A CG  1 
ATOM   188  C  CD  . GLN A 1 62  ? 141.845 141.147 116.613 1.00 45.30 ? 62  GLN A CD  1 
ATOM   189  O  OE1 . GLN A 1 62  ? 141.100 140.659 115.772 1.00 45.30 ? 62  GLN A OE1 1 
ATOM   190  N  NE2 . GLN A 1 62  ? 141.842 142.434 116.913 1.00 45.30 ? 62  GLN A NE2 1 
ATOM   191  N  N   . VAL A 1 63  ? 145.508 139.423 118.587 1.00 44.79 ? 63  VAL A N   1 
ATOM   192  C  CA  . VAL A 1 63  ? 146.580 140.408 118.636 1.00 44.79 ? 63  VAL A CA  1 
ATOM   193  C  C   . VAL A 1 63  ? 147.929 139.796 118.302 1.00 44.79 ? 63  VAL A C   1 
ATOM   194  O  O   . VAL A 1 63  ? 148.869 140.513 117.949 1.00 44.79 ? 63  VAL A O   1 
ATOM   195  C  CB  . VAL A 1 63  ? 146.365 141.246 119.912 1.00 44.79 ? 63  VAL A CB  1 
ATOM   196  C  CG1 . VAL A 1 63  ? 146.780 140.480 121.135 1.00 44.79 ? 63  VAL A CG1 1 
ATOM   197  C  CG2 . VAL A 1 63  ? 147.013 142.622 119.814 1.00 44.79 ? 63  VAL A CG2 1 
ATOM   198  N  N   . LEU A 1 64  ? 148.052 138.476 118.391 1.00 46.17 ? 64  LEU A N   1 
ATOM   199  C  CA  . LEU A 1 64  ? 149.143 137.738 117.790 1.00 46.17 ? 64  LEU A CA  1 
ATOM   200  C  C   . LEU A 1 64  ? 149.513 138.254 116.412 1.00 46.17 ? 64  LEU A C   1 
ATOM   201  O  O   . LEU A 1 64  ? 150.703 138.393 116.123 1.00 46.17 ? 64  LEU A O   1 
ATOM   202  C  CB  . LEU A 1 64  ? 148.878 136.238 117.837 1.00 46.17 ? 64  LEU A CB  1 
ATOM   203  C  CG  . LEU A 1 64  ? 150.014 135.253 117.645 1.00 46.17 ? 64  LEU A CG  1 
ATOM   204  C  CD1 . LEU A 1 64  ? 150.939 135.355 118.820 1.00 46.17 ? 64  LEU A CD1 1 
ATOM   205  C  CD2 . LEU A 1 64  ? 149.449 133.870 117.534 1.00 46.17 ? 64  LEU A CD2 1 
ATOM   206  N  N   . LEU A 1 65  ? 148.530 138.549 115.562 1.00 43.49 ? 65  LEU A N   1 
ATOM   207  C  CA  . LEU A 1 65  ? 148.787 138.921 114.183 1.00 43.49 ? 65  LEU A CA  1 
ATOM   208  C  C   . LEU A 1 65  ? 149.304 140.342 114.046 1.00 43.49 ? 65  LEU A C   1 
ATOM   209  O  O   . LEU A 1 65  ? 150.257 140.558 113.295 1.00 43.49 ? 65  LEU A O   1 
ATOM   210  C  CB  . LEU A 1 65  ? 147.570 138.514 113.348 1.00 43.49 ? 65  LEU A CB  1 
ATOM   211  C  CG  . LEU A 1 65  ? 147.327 137.010 113.322 1.00 43.49 ? 65  LEU A CG  1 
ATOM   212  C  CD1 . LEU A 1 65  ? 146.063 136.649 112.571 1.00 43.49 ? 65  LEU A CD1 1 
ATOM   213  C  CD2 . LEU A 1 65  ? 148.521 136.331 112.718 1.00 43.49 ? 65  LEU A CD2 1 
ATOM   214  N  N   . THR A 1 66  ? 148.715 141.310 114.739 1.00 40.59 ? 66  THR A N   1 
ATOM   215  C  CA  . THR A 1 66  ? 149.124 142.702 114.646 1.00 40.59 ? 66  THR A CA  1 
ATOM   216  C  C   . THR A 1 66  ? 150.491 143.121 115.156 1.00 40.59 ? 66  THR A C   1 
ATOM   217  O  O   . THR A 1 66  ? 151.035 144.105 114.660 1.00 40.59 ? 66  THR A O   1 
ATOM   218  C  CB  . THR A 1 66  ? 147.937 143.521 115.144 1.00 40.59 ? 66  THR A CB  1 
ATOM   219  O  OG1 . THR A 1 66  ? 147.801 143.337 116.554 1.00 40.59 ? 66  THR A OG1 1 
ATOM   220  C  CG2 . THR A 1 66  ? 146.674 143.068 114.475 1.00 40.59 ? 66  THR A CG2 1 
ATOM   221  N  N   . LEU A 1 67  ? 151.037 142.448 116.153 1.00 38.99 ? 67  LEU A N   1 
ATOM   222  C  CA  . LEU A 1 67  ? 152.407 142.698 116.597 1.00 38.99 ? 67  LEU A CA  1 
ATOM   223  C  C   . LEU A 1 67  ? 153.524 142.829 115.553 1.00 38.99 ? 67  LEU A C   1 
ATOM   224  O  O   . LEU A 1 67  ? 154.305 143.779 115.659 1.00 38.99 ? 67  LEU A O   1 
ATOM   225  C  CB  . LEU A 1 67  ? 152.764 141.754 117.741 1.00 38.99 ? 67  LEU A CB  1 
ATOM   226  C  CG  . LEU A 1 67  ? 151.842 141.887 118.947 1.00 38.99 ? 67  LEU A CG  1 
ATOM   227  C  CD1 . LEU A 1 67  ? 152.059 140.747 119.901 1.00 38.99 ? 67  LEU A CD1 1 
ATOM   228  C  CD2 . LEU A 1 67  ? 152.044 143.198 119.660 1.00 38.99 ? 67  LEU A CD2 1 
ATOM   229  N  N   . PRO A 1 68  ? 153.694 141.914 114.578 1.00 39.86 ? 68  PRO A N   1 
ATOM   230  C  CA  . PRO A 1 68  ? 154.527 142.271 113.422 1.00 39.86 ? 68  PRO A CA  1 
ATOM   231  C  C   . PRO A 1 68  ? 154.256 143.622 112.794 1.00 39.86 ? 68  PRO A C   1 
ATOM   232  O  O   . PRO A 1 68  ? 155.211 144.296 112.399 1.00 39.86 ? 68  PRO A O   1 
ATOM   233  C  CB  . PRO A 1 68  ? 154.296 141.134 112.427 1.00 39.86 ? 68  PRO A CB  1 
ATOM   234  C  CG  . PRO A 1 68  ? 153.983 140.016 113.259 1.00 39.86 ? 68  PRO A CG  1 
ATOM   235  C  CD  . PRO A 1 68  ? 153.163 140.534 114.372 1.00 39.86 ? 68  PRO A CD  1 
ATOM   236  N  N   . TYR A 1 69  ? 152.993 144.037 112.687 1.00 39.60 ? 69  TYR A N   1 
ATOM   237  C  CA  . TYR A 1 69  ? 152.674 145.395 112.257 1.00 39.60 ? 69  TYR A CA  1 
ATOM   238  C  C   . TYR A 1 69  ? 153.193 146.444 113.228 1.00 39.60 ? 69  TYR A C   1 
ATOM   239  O  O   . TYR A 1 69  ? 153.642 147.507 112.796 1.00 39.60 ? 69  TYR A O   1 
ATOM   240  C  CB  . TYR A 1 69  ? 151.164 145.541 112.096 1.00 39.60 ? 69  TYR A CB  1 
ATOM   241  C  CG  . TYR A 1 69  ? 150.681 146.957 111.889 1.00 39.60 ? 69  TYR A CG  1 
ATOM   242  C  CD1 . TYR A 1 69  ? 150.837 147.595 110.676 1.00 39.60 ? 69  TYR A CD1 1 
ATOM   243  C  CD2 . TYR A 1 69  ? 150.048 147.649 112.912 1.00 39.60 ? 69  TYR A CD2 1 
ATOM   244  C  CE1 . TYR A 1 69  ? 150.388 148.894 110.490 1.00 39.60 ? 69  TYR A CE1 1 
ATOM   245  C  CE2 . TYR A 1 69  ? 149.602 148.942 112.738 1.00 39.60 ? 69  TYR A CE2 1 
ATOM   246  C  CZ  . TYR A 1 69  ? 149.763 149.551 111.524 1.00 39.60 ? 69  TYR A CZ  1 
ATOM   247  O  OH  . TYR A 1 69  ? 149.319 150.835 111.358 1.00 39.60 ? 69  TYR A OH  1 
ATOM   248  N  N   . SER A 1 70  ? 153.153 146.169 114.531 1.00 39.09 ? 70  SER A N   1 
ATOM   249  C  CA  . SER A 1 70  ? 153.474 147.197 115.510 1.00 39.09 ? 70  SER A CA  1 
ATOM   250  C  C   . SER A 1 70  ? 154.947 147.247 115.870 1.00 39.09 ? 70  SER A C   1 
ATOM   251  O  O   . SER A 1 70  ? 155.351 148.146 116.607 1.00 39.09 ? 70  SER A O   1 
ATOM   252  C  CB  . SER A 1 70  ? 152.659 146.999 116.779 1.00 39.09 ? 70  SER A CB  1 
ATOM   253  O  OG  . SER A 1 70  ? 151.288 147.226 116.533 1.00 39.09 ? 70  SER A OG  1 
ATOM   254  N  N   . PHE A 1 71  ? 155.765 146.293 115.425 1.00 39.04 ? 71  PHE A N   1 
ATOM   255  C  CA  . PHE A 1 71  ? 157.197 146.497 115.603 1.00 39.04 ? 71  PHE A CA  1 
ATOM   256  C  C   . PHE A 1 71  ? 157.792 147.352 114.502 1.00 39.04 ? 71  PHE A C   1 
ATOM   257  O  O   . PHE A 1 71  ? 158.868 147.916 114.694 1.00 39.04 ? 71  PHE A O   1 
ATOM   258  C  CB  . PHE A 1 71  ? 157.970 145.184 115.679 1.00 39.04 ? 71  PHE A CB  1 
ATOM   259  C  CG  . PHE A 1 71  ? 157.888 144.496 117.006 1.00 39.04 ? 71  PHE A CG  1 
ATOM   260  C  CD1 . PHE A 1 71  ? 157.211 145.059 118.066 1.00 39.04 ? 71  PHE A CD1 1 
ATOM   261  C  CD2 . PHE A 1 71  ? 158.564 143.314 117.215 1.00 39.04 ? 71  PHE A CD2 1 
ATOM   262  C  CE1 . PHE A 1 71  ? 157.156 144.418 119.286 1.00 39.04 ? 71  PHE A CE1 1 
ATOM   263  C  CE2 . PHE A 1 71  ? 158.531 142.690 118.441 1.00 39.04 ? 71  PHE A CE2 1 
ATOM   264  C  CZ  . PHE A 1 71  ? 157.814 143.231 119.467 1.00 39.04 ? 71  PHE A CZ  1 
ATOM   265  N  N   . SER A 1 72  ? 157.126 147.465 113.362 1.00 41.21 ? 72  SER A N   1 
ATOM   266  C  CA  . SER A 1 72  ? 157.611 148.291 112.270 1.00 41.21 ? 72  SER A CA  1 
ATOM   267  C  C   . SER A 1 72  ? 157.432 149.775 112.534 1.00 41.21 ? 72  SER A C   1 
ATOM   268  O  O   . SER A 1 72  ? 158.099 150.587 111.891 1.00 41.21 ? 72  SER A O   1 
ATOM   269  C  CB  . SER A 1 72  ? 156.893 147.900 110.988 1.00 41.21 ? 72  SER A CB  1 
ATOM   270  O  OG  . SER A 1 72  ? 155.516 148.180 111.097 1.00 41.21 ? 72  SER A OG  1 
ATOM   271  N  N   . GLN A 1 73  ? 156.555 150.137 113.465 1.00 39.46 ? 73  GLN A N   1 
ATOM   272  C  CA  . GLN A 1 73  ? 156.386 151.500 113.942 1.00 39.46 ? 73  GLN A CA  1 
ATOM   273  C  C   . GLN A 1 73  ? 157.236 151.816 115.152 1.00 39.46 ? 73  GLN A C   1 
ATOM   274  O  O   . GLN A 1 73  ? 157.793 152.910 115.234 1.00 39.46 ? 73  GLN A O   1 
ATOM   275  C  CB  . GLN A 1 73  ? 154.927 151.740 114.317 1.00 39.46 ? 73  GLN A CB  1 
ATOM   276  C  CG  . GLN A 1 73  ? 153.998 151.653 113.164 1.00 39.46 ? 73  GLN A CG  1 
ATOM   277  C  CD  . GLN A 1 73  ? 152.582 151.722 113.605 1.00 39.46 ? 73  GLN A CD  1 
ATOM   278  O  OE1 . GLN A 1 73  ? 152.306 151.746 114.795 1.00 39.46 ? 73  GLN A OE1 1 
ATOM   279  N  NE2 . GLN A 1 73  ? 151.667 151.756 112.659 1.00 39.46 ? 73  GLN A NE2 1 
ATOM   280  N  N   . LEU A 1 74  ? 157.342 150.886 116.092 1.00 39.85 ? 74  LEU A N   1 
ATOM   281  C  CA  . LEU A 1 74  ? 158.173 151.095 117.263 1.00 39.85 ? 74  LEU A CA  1 
ATOM   282  C  C   . LEU A 1 74  ? 159.642 150.940 116.907 1.00 39.85 ? 74  LEU A C   1 
ATOM   283  O  O   . LEU A 1 74  ? 160.406 151.904 116.961 1.00 39.85 ? 74  LEU A O   1 
ATOM   284  C  CB  . LEU A 1 74  ? 157.772 150.111 118.360 1.00 39.85 ? 74  LEU A CB  1 
ATOM   285  C  CG  . LEU A 1 74  ? 156.387 150.286 118.957 1.00 39.85 ? 74  LEU A CG  1 
ATOM   286  C  CD1 . LEU A 1 74  ? 156.097 149.116 119.832 1.00 39.85 ? 74  LEU A CD1 1 
ATOM   287  C  CD2 . LEU A 1 74  ? 156.361 151.527 119.777 1.00 39.85 ? 74  LEU A CD2 1 
ATOM   288  N  N   . GLY A 1 75  ? 160.034 149.754 116.491 1.00 42.50 ? 75  GLY A N   1 
ATOM   289  C  CA  . GLY A 1 75  ? 161.438 149.445 116.371 1.00 42.50 ? 75  GLY A CA  1 
ATOM   290  C  C   . GLY A 1 75  ? 161.643 148.218 117.210 1.00 42.50 ? 75  GLY A C   1 
ATOM   291  O  O   . GLY A 1 75  ? 160.750 147.880 117.986 1.00 42.50 ? 75  GLY A O   1 
ATOM   292  N  N   . MET A 1 76  ? 162.766 147.522 117.074 1.00 46.97 ? 76  MET A N   1 
ATOM   293  C  CA  . MET A 1 76  ? 162.871 146.267 117.799 1.00 46.97 ? 76  MET A CA  1 
ATOM   294  C  C   . MET A 1 76  ? 163.224 146.488 119.257 1.00 46.97 ? 76  MET A C   1 
ATOM   295  O  O   . MET A 1 76  ? 162.620 145.858 120.125 1.00 46.97 ? 76  MET A O   1 
ATOM   296  C  CB  . MET A 1 76  ? 163.885 145.342 117.147 1.00 46.97 ? 76  MET A CB  1 
ATOM   297  C  CG  . MET A 1 76  ? 163.834 143.946 117.709 1.00 46.97 ? 76  MET A CG  1 
ATOM   298  S  SD  . MET A 1 76  ? 164.971 142.846 116.876 1.00 46.97 ? 76  MET A SD  1 
ATOM   299  C  CE  . MET A 1 76  ? 164.143 142.688 115.310 1.00 46.97 ? 76  MET A CE  1 
ATOM   300  N  N   . LEU A 1 77  ? 164.168 147.387 119.544 1.00 42.13 ? 77  LEU A N   1 
ATOM   301  C  CA  . LEU A 1 77  ? 164.622 147.576 120.918 1.00 42.13 ? 77  LEU A CA  1 
ATOM   302  C  C   . LEU A 1 77  ? 163.515 148.130 121.791 1.00 42.13 ? 77  LEU A C   1 
ATOM   303  O  O   . LEU A 1 77  ? 163.319 147.675 122.921 1.00 42.13 ? 77  LEU A O   1 
ATOM   304  C  CB  . LEU A 1 77  ? 165.826 148.507 120.954 1.00 42.13 ? 77  LEU A CB  1 
ATOM   305  C  CG  . LEU A 1 77  ? 166.322 148.764 122.374 1.00 42.13 ? 77  LEU A CG  1 
ATOM   306  C  CD1 . LEU A 1 77  ? 166.771 147.460 123.018 1.00 42.13 ? 77  LEU A CD1 1 
ATOM   307  C  CD2 . LEU A 1 77  ? 167.426 149.805 122.410 1.00 42.13 ? 77  LEU A CD2 1 
ATOM   308  N  N   . SER A 1 78  ? 162.730 149.045 121.253 1.00 40.81 ? 78  SER A N   1 
ATOM   309  C  CA  . SER A 1 78  ? 161.576 149.547 121.970 1.00 40.81 ? 78  SER A CA  1 
ATOM   310  C  C   . SER A 1 78  ? 160.377 148.625 121.848 1.00 40.81 ? 78  SER A C   1 
ATOM   311  O  O   . SER A 1 78  ? 159.311 148.955 122.361 1.00 40.81 ? 78  SER A O   1 
ATOM   312  C  CB  . SER A 1 78  ? 161.225 150.941 121.458 1.00 40.81 ? 78  SER A CB  1 
ATOM   313  O  OG  . SER A 1 78  ? 160.126 151.468 122.161 1.00 40.81 ? 78  SER A OG  1 
ATOM   314  N  N   . GLY A 1 79  ? 160.516 147.496 121.166 1.00 41.21 ? 79  GLY A N   1 
ATOM   315  C  CA  . GLY A 1 79  ? 159.419 146.570 121.010 1.00 41.21 ? 79  GLY A CA  1 
ATOM   316  C  C   . GLY A 1 79  ? 159.388 145.418 121.980 1.00 41.21 ? 79  GLY A C   1 
ATOM   317  O  O   . GLY A 1 79  ? 158.315 144.874 122.235 1.00 41.21 ? 79  GLY A O   1 
ATOM   318  N  N   . ILE A 1 80  ? 160.529 145.010 122.521 1.00 42.03 ? 80  ILE A N   1 
ATOM   319  C  CA  . ILE A 1 80  ? 160.566 144.012 123.579 1.00 42.03 ? 80  ILE A CA  1 
ATOM   320  C  C   . ILE A 1 80  ? 160.425 144.655 124.955 1.00 42.03 ? 80  ILE A C   1 
ATOM   321  O  O   . ILE A 1 80  ? 159.751 144.105 125.826 1.00 42.03 ? 80  ILE A O   1 
ATOM   322  C  CB  . ILE A 1 80  ? 161.854 143.162 123.472 1.00 42.03 ? 80  ILE A CB  1 
ATOM   323  C  CG1 . ILE A 1 80  ? 161.837 142.295 122.219 1.00 42.03 ? 80  ILE A CG1 1 
ATOM   324  C  CG2 . ILE A 1 80  ? 162.051 142.248 124.661 1.00 42.03 ? 80  ILE A CG2 1 
ATOM   325  C  CD1 . ILE A 1 80  ? 162.654 142.802 121.093 1.00 42.03 ? 80  ILE A CD1 1 
ATOM   326  N  N   . VAL A 1 81  ? 160.989 145.854 125.134 1.00 42.33 ? 81  VAL A N   1 
ATOM   327  C  CA  . VAL A 1 81  ? 160.988 146.529 126.433 1.00 42.33 ? 81  VAL A CA  1 
ATOM   328  C  C   . VAL A 1 81  ? 159.574 146.894 126.863 1.00 42.33 ? 81  VAL A C   1 
ATOM   329  O  O   . VAL A 1 81  ? 159.165 146.609 127.993 1.00 42.33 ? 81  VAL A O   1 
ATOM   330  C  CB  . VAL A 1 81  ? 161.899 147.765 126.387 1.00 42.33 ? 81  VAL A CB  1 
ATOM   331  C  CG1 . VAL A 1 81  ? 161.720 148.610 127.617 1.00 42.33 ? 81  VAL A CG1 1 
ATOM   332  C  CG2 . VAL A 1 81  ? 163.330 147.328 126.293 1.00 42.33 ? 81  VAL A CG2 1 
ATOM   333  N  N   . LEU A 1 82  ? 158.784 147.480 125.964 1.00 43.05 ? 82  LEU A N   1 
ATOM   334  C  CA  . LEU A 1 82  ? 157.397 147.770 126.316 1.00 43.05 ? 82  LEU A CA  1 
ATOM   335  C  C   . LEU A 1 82  ? 156.516 146.530 126.356 1.00 43.05 ? 82  LEU A C   1 
ATOM   336  O  O   . LEU A 1 82  ? 155.351 146.638 126.734 1.00 43.05 ? 82  LEU A O   1 
ATOM   337  C  CB  . LEU A 1 82  ? 156.768 148.766 125.348 1.00 43.05 ? 82  LEU A CB  1 
ATOM   338  C  CG  . LEU A 1 82  ? 157.260 150.202 125.369 1.00 43.05 ? 82  LEU A CG  1 
ATOM   339  C  CD1 . LEU A 1 82  ? 156.448 151.008 124.384 1.00 43.05 ? 82  LEU A CD1 1 
ATOM   340  C  CD2 . LEU A 1 82  ? 157.149 150.773 126.753 1.00 43.05 ? 82  LEU A CD2 1 
ATOM   341  N  N   . GLN A 1 83  ? 157.014 145.370 125.944 1.00 41.18 ? 83  GLN A N   1 
ATOM   342  C  CA  . GLN A 1 83  ? 156.195 144.175 126.060 1.00 41.18 ? 83  GLN A CA  1 
ATOM   343  C  C   . GLN A 1 83  ? 156.549 143.397 127.319 1.00 41.18 ? 83  GLN A C   1 
ATOM   344  O  O   . GLN A 1 83  ? 155.701 142.700 127.882 1.00 41.18 ? 83  GLN A O   1 
ATOM   345  C  CB  . GLN A 1 83  ? 156.349 143.331 124.805 1.00 41.18 ? 83  GLN A CB  1 
ATOM   346  C  CG  . GLN A 1 83  ? 155.297 142.302 124.653 1.00 41.18 ? 83  GLN A CG  1 
ATOM   347  C  CD  . GLN A 1 83  ? 155.279 141.715 123.280 1.00 41.18 ? 83  GLN A CD  1 
ATOM   348  O  OE1 . GLN A 1 83  ? 156.152 141.980 122.463 1.00 41.18 ? 83  GLN A OE1 1 
ATOM   349  N  NE2 . GLN A 1 83  ? 154.248 140.953 122.994 1.00 41.18 ? 83  GLN A NE2 1 
ATOM   350  N  N   . ILE A 1 84  ? 157.796 143.514 127.781 1.00 42.66 ? 84  ILE A N   1 
ATOM   351  C  CA  . ILE A 1 84  ? 158.141 143.097 129.137 1.00 42.66 ? 84  ILE A CA  1 
ATOM   352  C  C   . ILE A 1 84  ? 157.453 144.001 130.146 1.00 42.66 ? 84  ILE A C   1 
ATOM   353  O  O   . ILE A 1 84  ? 156.978 143.537 131.186 1.00 42.66 ? 84  ILE A O   1 
ATOM   354  C  CB  . ILE A 1 84  ? 159.673 143.105 129.326 1.00 42.66 ? 84  ILE A CB  1 
ATOM   355  C  CG1 . ILE A 1 84  ? 160.354 142.124 128.373 1.00 42.66 ? 84  ILE A CG1 1 
ATOM   356  C  CG2 . ILE A 1 84  ? 160.072 142.784 130.750 1.00 42.66 ? 84  ILE A CG2 1 
ATOM   357  C  CD1 . ILE A 1 84  ? 159.950 140.703 128.574 1.00 42.66 ? 84  ILE A CD1 1 
ATOM   358  N  N   . PHE A 1 85  ? 157.347 145.292 129.840 1.00 42.78 ? 85  PHE A N   1 
ATOM   359  C  CA  . PHE A 1 85  ? 156.868 146.248 130.829 1.00 42.78 ? 85  PHE A CA  1 
ATOM   360  C  C   . PHE A 1 85  ? 155.369 146.135 131.062 1.00 42.78 ? 85  PHE A C   1 
ATOM   361  O  O   . PHE A 1 85  ? 154.928 146.103 132.214 1.00 42.78 ? 85  PHE A O   1 
ATOM   362  C  CB  . PHE A 1 85  ? 157.234 147.664 130.409 1.00 42.78 ? 85  PHE A CB  1 
ATOM   363  C  CG  . PHE A 1 85  ? 156.678 148.706 131.305 1.00 42.78 ? 85  PHE A CG  1 
ATOM   364  C  CD1 . PHE A 1 85  ? 157.158 148.848 132.581 1.00 42.78 ? 85  PHE A CD1 1 
ATOM   365  C  CD2 . PHE A 1 85  ? 155.688 149.554 130.868 1.00 42.78 ? 85  PHE A CD2 1 
ATOM   366  C  CE1 . PHE A 1 85  ? 156.645 149.802 133.414 1.00 42.78 ? 85  PHE A CE1 1 
ATOM   367  C  CE2 . PHE A 1 85  ? 155.173 150.510 131.694 1.00 42.78 ? 85  PHE A CE2 1 
ATOM   368  C  CZ  . PHE A 1 85  ? 155.654 150.636 132.969 1.00 42.78 ? 85  PHE A CZ  1 
ATOM   369  N  N   . TYR A 1 86  ? 154.562 146.089 130.002 1.00 43.10 ? 86  TYR A N   1 
ATOM   370  C  CA  . TYR A 1 86  ? 153.120 146.027 130.212 1.00 43.10 ? 86  TYR A CA  1 
ATOM   371  C  C   . TYR A 1 86  ? 152.676 144.664 130.714 1.00 43.10 ? 86  TYR A C   1 
ATOM   372  O  O   . TYR A 1 86  ? 151.657 144.565 131.399 1.00 43.10 ? 86  TYR A O   1 
ATOM   373  C  CB  . TYR A 1 86  ? 152.373 146.391 128.935 1.00 43.10 ? 86  TYR A CB  1 
ATOM   374  C  CG  . TYR A 1 86  ? 152.296 147.874 128.675 1.00 43.10 ? 86  TYR A CG  1 
ATOM   375  C  CD1 . TYR A 1 86  ? 152.501 148.789 129.690 1.00 43.10 ? 86  TYR A CD1 1 
ATOM   376  C  CD2 . TYR A 1 86  ? 152.021 148.357 127.412 1.00 43.10 ? 86  TYR A CD2 1 
ATOM   377  C  CE1 . TYR A 1 86  ? 152.434 150.145 129.451 1.00 43.10 ? 86  TYR A CE1 1 
ATOM   378  C  CE2 . TYR A 1 86  ? 151.955 149.703 127.166 1.00 43.10 ? 86  TYR A CE2 1 
ATOM   379  C  CZ  . TYR A 1 86  ? 152.159 150.591 128.184 1.00 43.10 ? 86  TYR A CZ  1 
ATOM   380  O  OH  . TYR A 1 86  ? 152.086 151.935 127.923 1.00 43.10 ? 86  TYR A OH  1 
ATOM   381  N  N   . GLY A 1 87  ? 153.424 143.606 130.404 1.00 42.72 ? 87  GLY A N   1 
ATOM   382  C  CA  . GLY A 1 87  ? 153.026 142.275 130.835 1.00 42.72 ? 87  GLY A CA  1 
ATOM   383  C  C   . GLY A 1 87  ? 153.289 142.008 132.302 1.00 42.72 ? 87  GLY A C   1 
ATOM   384  O  O   . GLY A 1 87  ? 152.748 141.057 132.868 1.00 42.72 ? 87  GLY A O   1 
ATOM   385  N  N   . LEU A 1 88  ? 154.144 142.812 132.929 1.00 42.99 ? 88  LEU A N   1 
ATOM   386  C  CA  . LEU A 1 88  ? 154.367 142.673 134.362 1.00 42.99 ? 88  LEU A CA  1 
ATOM   387  C  C   . LEU A 1 88  ? 153.535 143.677 135.143 1.00 42.99 ? 88  LEU A C   1 
ATOM   388  O  O   . LEU A 1 88  ? 153.019 143.363 136.219 1.00 42.99 ? 88  LEU A O   1 
ATOM   389  C  CB  . LEU A 1 88  ? 155.847 142.845 134.683 1.00 42.99 ? 88  LEU A CB  1 
ATOM   390  C  CG  . LEU A 1 88  ? 156.775 141.804 134.064 1.00 42.99 ? 88  LEU A CG  1 
ATOM   391  C  CD1 . LEU A 1 88  ? 158.217 142.113 134.400 1.00 42.99 ? 88  LEU A CD1 1 
ATOM   392  C  CD2 . LEU A 1 88  ? 156.401 140.388 134.476 1.00 42.99 ? 88  LEU A CD2 1 
ATOM   393  N  N   . LEU A 1 89  ? 153.403 144.895 134.618 1.00 44.03 ? 89  LEU A N   1 
ATOM   394  C  CA  . LEU A 1 89  ? 152.514 145.887 135.203 1.00 44.03 ? 89  LEU A CA  1 
ATOM   395  C  C   . LEU A 1 89  ? 151.053 145.490 135.059 1.00 44.03 ? 89  LEU A C   1 
ATOM   396  O  O   . LEU A 1 89  ? 150.228 145.875 135.890 1.00 44.03 ? 89  LEU A O   1 
ATOM   397  C  CB  . LEU A 1 89  ? 152.752 147.236 134.535 1.00 44.03 ? 89  LEU A CB  1 
ATOM   398  C  CG  . LEU A 1 89  ? 152.104 148.454 135.166 1.00 44.03 ? 89  LEU A CG  1 
ATOM   399  C  CD1 . LEU A 1 89  ? 152.756 148.663 136.503 1.00 44.03 ? 89  LEU A CD1 1 
ATOM   400  C  CD2 . LEU A 1 89  ? 152.269 149.665 134.278 1.00 44.03 ? 89  LEU A CD2 1 
ATOM   401  N  N   . GLY A 1 90  ? 150.716 144.732 134.016 1.00 43.69 ? 90  GLY A N   1 
ATOM   402  C  CA  . GLY A 1 90  ? 149.375 144.211 133.851 1.00 43.69 ? 90  GLY A CA  1 
ATOM   403  C  C   . GLY A 1 90  ? 149.109 142.909 134.569 1.00 43.69 ? 90  GLY A C   1 
ATOM   404  O  O   . GLY A 1 90  ? 148.050 142.314 134.365 1.00 43.69 ? 90  GLY A O   1 
ATOM   405  N  N   . SER A 1 91  ? 150.069 142.426 135.361 1.00 46.37 ? 91  SER A N   1 
ATOM   406  C  CA  . SER A 1 91  ? 149.836 141.296 136.256 1.00 46.37 ? 91  SER A CA  1 
ATOM   407  C  C   . SER A 1 91  ? 149.677 141.747 137.698 1.00 46.37 ? 91  SER A C   1 
ATOM   408  O  O   . SER A 1 91  ? 148.987 141.090 138.482 1.00 46.37 ? 91  SER A O   1 
ATOM   409  C  CB  . SER A 1 91  ? 150.981 140.301 136.166 1.00 46.37 ? 91  SER A CB  1 
ATOM   410  O  OG  . SER A 1 91  ? 150.827 139.318 137.162 1.00 46.37 ? 91  SER A OG  1 
ATOM   411  N  N   . TRP A 1 92  ? 150.332 142.850 138.065 1.00 50.94 ? 92  TRP A N   1 
ATOM   412  C  CA  . TRP A 1 92  ? 150.152 143.454 139.378 1.00 50.94 ? 92  TRP A CA  1 
ATOM   413  C  C   . TRP A 1 92  ? 148.737 143.975 139.568 1.00 50.94 ? 92  TRP A C   1 
ATOM   414  O  O   . TRP A 1 92  ? 148.233 144.011 140.691 1.00 50.94 ? 92  TRP A O   1 
ATOM   415  C  CB  . TRP A 1 92  ? 151.170 144.571 139.549 1.00 50.94 ? 92  TRP A CB  1 
ATOM   416  C  CG  . TRP A 1 92  ? 150.987 145.435 140.723 1.00 50.94 ? 92  TRP A CG  1 
ATOM   417  C  CD1 . TRP A 1 92  ? 150.484 146.685 140.720 1.00 50.94 ? 92  TRP A CD1 1 
ATOM   418  C  CD2 . TRP A 1 92  ? 151.343 145.147 142.075 1.00 50.94 ? 92  TRP A CD2 1 
ATOM   419  N  NE1 . TRP A 1 92  ? 150.478 147.198 141.984 1.00 50.94 ? 92  TRP A NE1 1 
ATOM   420  C  CE2 . TRP A 1 92  ? 151.000 146.269 142.839 1.00 50.94 ? 92  TRP A CE2 1 
ATOM   421  C  CE3 . TRP A 1 92  ? 151.905 144.044 142.716 1.00 50.94 ? 92  TRP A CE3 1 
ATOM   422  C  CZ2 . TRP A 1 92  ? 151.202 146.324 144.210 1.00 50.94 ? 92  TRP A CZ2 1 
ATOM   423  C  CZ3 . TRP A 1 92  ? 152.105 144.101 144.076 1.00 50.94 ? 92  TRP A CZ3 1 
ATOM   424  C  CH2 . TRP A 1 92  ? 151.755 145.233 144.809 1.00 50.94 ? 92  TRP A CH2 1 
ATOM   425  N  N   . THR A 1 93  ? 148.068 144.369 138.486 1.00 48.70 ? 93  THR A N   1 
ATOM   426  C  CA  . THR A 1 93  ? 146.683 144.798 138.622 1.00 48.70 ? 93  THR A CA  1 
ATOM   427  C  C   . THR A 1 93  ? 145.736 143.611 138.687 1.00 48.70 ? 93  THR A C   1 
ATOM   428  O  O   . THR A 1 93  ? 144.616 143.747 139.184 1.00 48.70 ? 93  THR A O   1 
ATOM   429  C  CB  . THR A 1 93  ? 146.284 145.717 137.478 1.00 48.70 ? 93  THR A CB  1 
ATOM   430  O  OG1 . THR A 1 93  ? 146.295 144.978 136.260 1.00 48.70 ? 93  THR A OG1 1 
ATOM   431  C  CG2 . THR A 1 93  ? 147.257 146.869 137.366 1.00 48.70 ? 93  THR A CG2 1 
ATOM   432  N  N   . ALA A 1 94  ? 146.145 142.449 138.180 1.00 49.58 ? 94  ALA A N   1 
ATOM   433  C  CA  . ALA A 1 94  ? 145.344 141.251 138.389 1.00 49.58 ? 94  ALA A CA  1 
ATOM   434  C  C   . ALA A 1 94  ? 145.704 140.552 139.684 1.00 49.58 ? 94  ALA A C   1 
ATOM   435  O  O   . ALA A 1 94  ? 145.033 139.592 140.062 1.00 49.58 ? 94  ALA A O   1 
ATOM   436  C  CB  . ALA A 1 94  ? 145.496 140.295 137.218 1.00 49.58 ? 94  ALA A CB  1 
ATOM   437  N  N   . TYR A 1 95  ? 146.783 140.978 140.337 1.00 51.25 ? 95  TYR A N   1 
ATOM   438  C  CA  . TYR A 1 95  ? 146.979 140.661 141.746 1.00 51.25 ? 95  TYR A CA  1 
ATOM   439  C  C   . TYR A 1 95  ? 145.999 141.426 142.613 1.00 51.25 ? 95  TYR A C   1 
ATOM   440  O  O   . TYR A 1 95  ? 145.490 140.891 143.600 1.00 51.25 ? 95  TYR A O   1 
ATOM   441  C  CB  . TYR A 1 95  ? 148.406 140.989 142.160 1.00 51.25 ? 95  TYR A CB  1 
ATOM   442  C  CG  . TYR A 1 95  ? 148.659 140.940 143.643 1.00 51.25 ? 95  TYR A CG  1 
ATOM   443  C  CD1 . TYR A 1 95  ? 148.805 139.743 144.307 1.00 51.25 ? 95  TYR A CD1 1 
ATOM   444  C  CD2 . TYR A 1 95  ? 148.775 142.107 144.378 1.00 51.25 ? 95  TYR A CD2 1 
ATOM   445  C  CE1 . TYR A 1 95  ? 149.057 139.712 145.657 1.00 51.25 ? 95  TYR A CE1 1 
ATOM   446  C  CE2 . TYR A 1 95  ? 149.014 142.079 145.731 1.00 51.25 ? 95  TYR A CE2 1 
ATOM   447  C  CZ  . TYR A 1 95  ? 149.150 140.877 146.363 1.00 51.25 ? 95  TYR A CZ  1 
ATOM   448  O  OH  . TYR A 1 95  ? 149.393 140.844 147.711 1.00 51.25 ? 95  TYR A OH  1 
ATOM   449  N  N   . LEU A 1 96  ? 145.733 142.685 142.268 1.00 49.43 ? 96  LEU A N   1 
ATOM   450  C  CA  . LEU A 1 96  ? 144.859 143.513 143.085 1.00 49.43 ? 96  LEU A CA  1 
ATOM   451  C  C   . LEU A 1 96  ? 143.406 143.089 142.970 1.00 49.43 ? 96  LEU A C   1 
ATOM   452  O  O   . LEU A 1 96  ? 142.618 143.339 143.883 1.00 49.43 ? 96  LEU A O   1 
ATOM   453  C  CB  . LEU A 1 96  ? 145.003 144.973 142.695 1.00 49.43 ? 96  LEU A CB  1 
ATOM   454  C  CG  . LEU A 1 96  ? 146.354 145.585 142.996 1.00 49.43 ? 96  LEU A CG  1 
ATOM   455  C  CD1 . LEU A 1 96  ? 146.396 146.967 142.425 1.00 49.43 ? 96  LEU A CD1 1 
ATOM   456  C  CD2 . LEU A 1 96  ? 146.550 145.624 144.475 1.00 49.43 ? 96  LEU A CD2 1 
ATOM   457  N  N   . ILE A 1 97  ? 143.023 142.464 141.861 1.00 49.34 ? 97  ILE A N   1 
ATOM   458  C  CA  . ILE A 1 97  ? 141.703 141.856 141.829 1.00 49.34 ? 97  ILE A CA  1 
ATOM   459  C  C   . ILE A 1 97  ? 141.693 140.591 142.687 1.00 49.34 ? 97  ILE A C   1 
ATOM   460  O  O   . ILE A 1 97  ? 140.664 140.234 143.272 1.00 49.34 ? 97  ILE A O   1 
ATOM   461  C  CB  . ILE A 1 97  ? 141.283 141.609 140.368 1.00 49.34 ? 97  ILE A CB  1 
ATOM   462  C  CG1 . ILE A 1 97  ? 141.207 142.935 139.618 1.00 49.34 ? 97  ILE A CG1 1 
ATOM   463  C  CG2 . ILE A 1 97  ? 139.935 140.976 140.276 1.00 49.34 ? 97  ILE A CG2 1 
ATOM   464  C  CD1 . ILE A 1 97  ? 140.965 142.785 138.139 1.00 49.34 ? 97  ILE A CD1 1 
ATOM   465  N  N   . SER A 1 98  ? 142.841 139.935 142.849 1.00 51.98 ? 98  SER A N   1 
ATOM   466  C  CA  . SER A 1 98  ? 142.872 138.733 143.674 1.00 51.98 ? 98  SER A CA  1 
ATOM   467  C  C   . SER A 1 98  ? 142.830 139.067 145.157 1.00 51.98 ? 98  SER A C   1 
ATOM   468  O  O   . SER A 1 98  ? 142.485 138.213 145.975 1.00 51.98 ? 98  SER A O   1 
ATOM   469  C  CB  . SER A 1 98  ? 144.103 137.896 143.353 1.00 51.98 ? 98  SER A CB  1 
ATOM   470  O  OG  . SER A 1 98  ? 145.274 138.564 143.764 1.00 51.98 ? 98  SER A OG  1 
ATOM   471  N  N   . VAL A 1 99  ? 143.191 140.291 145.532 1.00 51.32 ? 99  VAL A N   1 
ATOM   472  C  CA  . VAL A 1 99  ? 143.069 140.680 146.931 1.00 51.32 ? 99  VAL A CA  1 
ATOM   473  C  C   . VAL A 1 99  ? 141.664 141.185 147.216 1.00 51.32 ? 99  VAL A C   1 
ATOM   474  O  O   . VAL A 1 99  ? 141.055 140.824 148.228 1.00 51.32 ? 99  VAL A O   1 
ATOM   475  C  CB  . VAL A 1 99  ? 144.146 141.717 147.298 1.00 51.32 ? 99  VAL A CB  1 
ATOM   476  C  CG1 . VAL A 1 99  ? 143.941 142.246 148.690 1.00 51.32 ? 99  VAL A CG1 1 
ATOM   477  C  CG2 . VAL A 1 99  ? 145.505 141.079 147.215 1.00 51.32 ? 99  VAL A CG2 1 
ATOM   478  N  N   . LEU A 1 100 ? 141.099 141.975 146.305 1.00 50.28 ? 100 LEU A N   1 
ATOM   479  C  CA  . LEU A 1 100 ? 139.805 142.600 146.541 1.00 50.28 ? 100 LEU A CA  1 
ATOM   480  C  C   . LEU A 1 100 ? 138.635 141.632 146.476 1.00 50.28 ? 100 LEU A C   1 
ATOM   481  O  O   . LEU A 1 100 ? 137.520 142.024 146.811 1.00 50.28 ? 100 LEU A O   1 
ATOM   482  C  CB  . LEU A 1 100 ? 139.590 143.738 145.556 1.00 50.28 ? 100 LEU A CB  1 
ATOM   483  C  CG  . LEU A 1 100 ? 140.481 144.937 145.842 1.00 50.28 ? 100 LEU A CG  1 
ATOM   484  C  CD1 . LEU A 1 100 ? 140.314 145.970 144.763 1.00 50.28 ? 100 LEU A CD1 1 
ATOM   485  C  CD2 . LEU A 1 100 ? 140.112 145.501 147.185 1.00 50.28 ? 100 LEU A CD2 1 
ATOM   486  N  N   . TYR A 1 101 ? 138.852 140.392 146.061 1.00 53.31 ? 101 TYR A N   1 
ATOM   487  C  CA  . TYR A 1 101 ? 137.825 139.371 146.198 1.00 53.31 ? 101 TYR A CA  1 
ATOM   488  C  C   . TYR A 1 101 ? 137.956 138.640 147.523 1.00 53.31 ? 101 TYR A C   1 
ATOM   489  O  O   . TYR A 1 101 ? 136.963 138.153 148.069 1.00 53.31 ? 101 TYR A O   1 
ATOM   490  C  CB  . TYR A 1 101 ? 137.910 138.403 145.026 1.00 53.31 ? 101 TYR A CB  1 
ATOM   491  C  CG  . TYR A 1 101 ? 136.998 137.215 145.120 1.00 53.31 ? 101 TYR A CG  1 
ATOM   492  C  CD1 . TYR A 1 101 ? 135.633 137.359 145.005 1.00 53.31 ? 101 TYR A CD1 1 
ATOM   493  C  CD2 . TYR A 1 101 ? 137.509 135.941 145.288 1.00 53.31 ? 101 TYR A CD2 1 
ATOM   494  C  CE1 . TYR A 1 101 ? 134.803 136.273 145.082 1.00 53.31 ? 101 TYR A CE1 1 
ATOM   495  C  CE2 . TYR A 1 101 ? 136.684 134.852 145.357 1.00 53.31 ? 101 TYR A CE2 1 
ATOM   496  C  CZ  . TYR A 1 101 ? 135.338 135.028 145.253 1.00 53.31 ? 101 TYR A CZ  1 
ATOM   497  O  OH  . TYR A 1 101 ? 134.513 133.943 145.326 1.00 53.31 ? 101 TYR A OH  1 
ATOM   498  N  N   . VAL A 1 102 ? 139.175 138.553 148.051 1.00 54.12 ? 102 VAL A N   1 
ATOM   499  C  CA  . VAL A 1 102 ? 139.371 138.025 149.394 1.00 54.12 ? 102 VAL A CA  1 
ATOM   500  C  C   . VAL A 1 102 ? 138.761 138.965 150.421 1.00 54.12 ? 102 VAL A C   1 
ATOM   501  O  O   . VAL A 1 102 ? 138.126 138.524 151.384 1.00 54.12 ? 102 VAL A O   1 
ATOM   502  C  CB  . VAL A 1 102 ? 140.868 137.787 149.644 1.00 54.12 ? 102 VAL A CB  1 
ATOM   503  C  CG1 . VAL A 1 102 ? 141.121 137.411 151.071 1.00 54.12 ? 102 VAL A CG1 1 
ATOM   504  C  CG2 . VAL A 1 102 ? 141.375 136.698 148.731 1.00 54.12 ? 102 VAL A CG2 1 
ATOM   505  N  N   . GLU A 1 103 ? 138.895 140.275 150.200 1.00 54.10 ? 103 GLU A N   1 
ATOM   506  C  CA  . GLU A 1 103 ? 138.326 141.265 151.108 1.00 54.10 ? 103 GLU A CA  1 
ATOM   507  C  C   . GLU A 1 103 ? 136.804 141.253 151.083 1.00 54.10 ? 103 GLU A C   1 
ATOM   508  O  O   . GLU A 1 103 ? 136.170 141.440 152.123 1.00 54.10 ? 103 GLU A O   1 
ATOM   509  C  CB  . GLU A 1 103 ? 138.851 142.649 150.751 1.00 54.10 ? 103 GLU A CB  1 
ATOM   510  C  CG  . GLU A 1 103 ? 138.388 143.753 151.656 1.00 54.10 ? 103 GLU A CG  1 
ATOM   511  C  CD  . GLU A 1 103 ? 138.962 143.657 153.038 1.00 54.10 ? 103 GLU A CD  1 
ATOM   512  O  OE1 . GLU A 1 103 ? 140.068 143.106 153.177 1.00 54.10 ? 103 GLU A OE1 1 
ATOM   513  O  OE2 . GLU A 1 103 ? 138.319 144.146 153.989 1.00 54.10 ? 103 GLU A OE2 1 
ATOM   514  N  N   . TYR A 1 104 ? 136.203 141.012 149.921 1.00 53.74 ? 104 TYR A N   1 
ATOM   515  C  CA  . TYR A 1 104 ? 134.752 140.902 149.852 1.00 53.74 ? 104 TYR A CA  1 
ATOM   516  C  C   . TYR A 1 104 ? 134.268 139.611 150.485 1.00 53.74 ? 104 TYR A C   1 
ATOM   517  O  O   . TYR A 1 104 ? 133.145 139.540 150.989 1.00 53.74 ? 104 TYR A O   1 
ATOM   518  C  CB  . TYR A 1 104 ? 134.301 140.986 148.406 1.00 53.74 ? 104 TYR A CB  1 
ATOM   519  C  CG  . TYR A 1 104 ? 132.830 140.845 148.204 1.00 53.74 ? 104 TYR A CG  1 
ATOM   520  C  CD1 . TYR A 1 104 ? 131.966 141.841 148.601 1.00 53.74 ? 104 TYR A CD1 1 
ATOM   521  C  CD2 . TYR A 1 104 ? 132.307 139.737 147.562 1.00 53.74 ? 104 TYR A CD2 1 
ATOM   522  C  CE1 . TYR A 1 104 ? 130.615 141.727 148.402 1.00 53.74 ? 104 TYR A CE1 1 
ATOM   523  C  CE2 . TYR A 1 104 ? 130.959 139.613 147.354 1.00 53.74 ? 104 TYR A CE2 1 
ATOM   524  C  CZ  . TYR A 1 104 ? 130.118 140.613 147.773 1.00 53.74 ? 104 TYR A CZ  1 
ATOM   525  O  OH  . TYR A 1 104 ? 128.768 140.493 147.567 1.00 53.74 ? 104 TYR A OH  1 
ATOM   526  N  N   . ARG A 1 105 ? 135.103 138.580 150.469 1.00 55.75 ? 105 ARG A N   1 
ATOM   527  C  CA  . ARG A 1 105 ? 134.717 137.309 151.058 1.00 55.75 ? 105 ARG A CA  1 
ATOM   528  C  C   . ARG A 1 105 ? 134.733 137.385 152.582 1.00 55.75 ? 105 ARG A C   1 
ATOM   529  O  O   . ARG A 1 105 ? 133.917 136.746 153.252 1.00 55.75 ? 105 ARG A O   1 
ATOM   530  C  CB  . ARG A 1 105 ? 135.649 136.221 150.528 1.00 55.75 ? 105 ARG A CB  1 
ATOM   531  C  CG  . ARG A 1 105 ? 135.432 134.843 151.089 1.00 55.75 ? 105 ARG A CG  1 
ATOM   532  C  CD  . ARG A 1 105 ? 134.097 134.273 150.690 1.00 55.75 ? 105 ARG A CD  1 
ATOM   533  N  NE  . ARG A 1 105 ? 134.039 133.930 149.280 1.00 55.75 ? 105 ARG A NE  1 
ATOM   534  C  CZ  . ARG A 1 105 ? 132.919 133.594 148.653 1.00 55.75 ? 105 ARG A CZ  1 
ATOM   535  N  NH1 . ARG A 1 105 ? 131.775 133.566 149.322 1.00 55.75 ? 105 ARG A NH1 1 
ATOM   536  N  NH2 . ARG A 1 105 ? 132.940 133.283 147.363 1.00 55.75 ? 105 ARG A NH2 1 
ATOM   537  N  N   . ALA A 1 106 ? 135.634 138.180 153.148 1.00 54.99 ? 106 ALA A N   1 
ATOM   538  C  CA  . ALA A 1 106 ? 135.729 138.314 154.593 1.00 54.99 ? 106 ALA A CA  1 
ATOM   539  C  C   . ALA A 1 106 ? 135.040 139.559 155.131 1.00 54.99 ? 106 ALA A C   1 
ATOM   540  O  O   . ALA A 1 106 ? 135.247 139.897 156.299 1.00 54.99 ? 106 ALA A O   1 
ATOM   541  C  CB  . ALA A 1 106 ? 137.192 138.315 155.024 1.00 54.99 ? 106 ALA A CB  1 
ATOM   542  N  N   . ARG A 1 107 ? 134.254 140.261 154.318 1.00 56.10 ? 107 ARG A N   1 
ATOM   543  C  CA  . ARG A 1 107 ? 133.350 141.295 154.805 1.00 56.10 ? 107 ARG A CA  1 
ATOM   544  C  C   . ARG A 1 107 ? 131.895 140.886 154.645 1.00 56.10 ? 107 ARG A C   1 
ATOM   545  O  O   . ARG A 1 107 ? 131.036 141.724 154.378 1.00 56.10 ? 107 ARG A O   1 
ATOM   546  C  CB  . ARG A 1 107 ? 133.573 142.627 154.100 1.00 56.10 ? 107 ARG A CB  1 
ATOM   547  C  CG  . ARG A 1 107 ? 134.834 143.340 154.488 1.00 56.10 ? 107 ARG A CG  1 
ATOM   548  C  CD  . ARG A 1 107 ? 134.877 144.710 153.856 1.00 56.10 ? 107 ARG A CD  1 
ATOM   549  N  NE  . ARG A 1 107 ? 136.108 145.413 154.175 1.00 56.10 ? 107 ARG A NE  1 
ATOM   550  C  CZ  . ARG A 1 107 ? 136.373 146.650 153.782 1.00 56.10 ? 107 ARG A CZ  1 
ATOM   551  N  NH1 . ARG A 1 107 ? 135.483 147.315 153.068 1.00 56.10 ? 107 ARG A NH1 1 
ATOM   552  N  NH2 . ARG A 1 107 ? 137.519 147.217 154.108 1.00 56.10 ? 107 ARG A NH2 1 
ATOM   553  N  N   . LYS A 1 108 ? 131.614 139.596 154.756 1.00 60.85 ? 108 LYS A N   1 
ATOM   554  C  CA  . LYS A 1 108 ? 130.253 139.136 154.934 1.00 60.85 ? 108 LYS A CA  1 
ATOM   555  C  C   . LYS A 1 108 ? 130.059 138.425 156.257 1.00 60.85 ? 108 LYS A C   1 
ATOM   556  O  O   . LYS A 1 108 ? 128.930 138.354 156.746 1.00 60.85 ? 108 LYS A O   1 
ATOM   557  C  CB  . LYS A 1 108 ? 129.839 138.198 153.796 1.00 60.85 ? 108 LYS A CB  1 
ATOM   558  C  CG  . LYS A 1 108 ? 129.764 138.858 152.442 1.00 60.85 ? 108 LYS A CG  1 
ATOM   559  C  CD  . LYS A 1 108 ? 129.066 137.952 151.461 1.00 60.85 ? 108 LYS A CD  1 
ATOM   560  C  CE  . LYS A 1 108 ? 129.928 136.759 151.128 1.00 60.85 ? 108 LYS A CE  1 
ATOM   561  N  NZ  . LYS A 1 108 ? 129.312 135.882 150.103 1.00 60.85 ? 108 LYS A NZ  1 
ATOM   562  N  N   . GLU A 1 109 ? 131.135 137.922 156.852 1.00 60.90 ? 109 GLU A N   1 
ATOM   563  C  CA  . GLU A 1 109 ? 131.037 137.313 158.165 1.00 60.90 ? 109 GLU A CA  1 
ATOM   564  C  C   . GLU A 1 109 ? 130.804 138.370 159.232 1.00 60.90 ? 109 GLU A C   1 
ATOM   565  O  O   . GLU A 1 109 ? 130.120 138.114 160.227 1.00 60.90 ? 109 GLU A O   1 
ATOM   566  C  CB  . GLU A 1 109 ? 132.306 136.527 158.442 1.00 60.90 ? 109 GLU A CB  1 
ATOM   567  C  CG  . GLU A 1 109 ? 132.631 135.528 157.346 1.00 60.90 ? 109 GLU A CG  1 
ATOM   568  C  CD  . GLU A 1 109 ? 131.626 134.403 157.233 1.00 60.90 ? 109 GLU A CD  1 
ATOM   569  O  OE1 . GLU A 1 109 ? 131.078 133.982 158.272 1.00 60.90 ? 109 GLU A OE1 1 
ATOM   570  O  OE2 . GLU A 1 109 ? 131.383 133.935 156.101 1.00 60.90 ? 109 GLU A OE2 1 
ATOM   571  N  N   . LYS A 1 110 ? 131.333 139.570 159.029 1.00 61.50 ? 110 LYS A N   1 
ATOM   572  C  CA  . LYS A 1 110 ? 131.061 140.683 159.926 1.00 61.50 ? 110 LYS A CA  1 
ATOM   573  C  C   . LYS A 1 110 ? 129.660 141.240 159.765 1.00 61.50 ? 110 LYS A C   1 
ATOM   574  O  O   . LYS A 1 110 ? 129.208 141.984 160.637 1.00 61.50 ? 110 LYS A O   1 
ATOM   575  C  CB  . LYS A 1 110 ? 132.067 141.820 159.722 1.00 61.50 ? 110 LYS A CB  1 
ATOM   576  C  CG  . LYS A 1 110 ? 133.358 141.718 160.516 1.00 61.50 ? 110 LYS A CG  1 
ATOM   577  C  CD  . LYS A 1 110 ? 134.339 140.758 159.883 1.00 61.50 ? 110 LYS A CD  1 
ATOM   578  C  CE  . LYS A 1 110 ? 135.675 140.801 160.589 1.00 61.50 ? 110 LYS A CE  1 
ATOM   579  N  NZ  . LYS A 1 110 ? 136.629 139.804 160.030 1.00 61.50 ? 110 LYS A NZ  1 
ATOM   580  N  N   . GLU A 1 111 ? 128.964 140.920 158.684 1.00 66.63 ? 111 GLU A N   1 
ATOM   581  C  CA  . GLU A 1 111 ? 127.620 141.432 158.477 1.00 66.63 ? 111 GLU A CA  1 
ATOM   582  C  C   . GLU A 1 111 ? 126.544 140.369 158.494 1.00 66.63 ? 111 GLU A C   1 
ATOM   583  O  O   . GLU A 1 111 ? 125.363 140.726 158.565 1.00 66.63 ? 111 GLU A O   1 
ATOM   584  C  CB  . GLU A 1 111 ? 127.537 142.214 157.157 1.00 66.63 ? 111 GLU A CB  1 
ATOM   585  C  CG  . GLU A 1 111 ? 128.080 143.640 157.252 1.00 66.63 ? 111 GLU A CG  1 
ATOM   586  C  CD  . GLU A 1 111 ? 129.594 143.736 157.170 1.00 66.63 ? 111 GLU A CD  1 
ATOM   587  O  OE1 . GLU A 1 111 ? 130.259 142.701 156.971 1.00 66.63 ? 111 GLU A OE1 1 
ATOM   588  O  OE2 . GLU A 1 111 ? 130.123 144.860 157.310 1.00 66.63 ? 111 GLU A OE2 1 
ATOM   589  N  N   . GLY A 1 112 ? 126.899 139.092 158.455 1.00 65.77 ? 112 GLY A N   1 
ATOM   590  C  CA  . GLY A 1 112 ? 125.921 138.034 158.580 1.00 65.77 ? 112 GLY A CA  1 
ATOM   591  C  C   . GLY A 1 112 ? 125.002 137.928 157.388 1.00 65.77 ? 112 GLY A C   1 
ATOM   592  O  O   . GLY A 1 112 ? 123.811 138.234 157.492 1.00 65.77 ? 112 GLY A O   1 
ATOM   593  N  N   . LYS A 1 113 ? 125.548 137.517 156.251 1.00 67.02 ? 113 LYS A N   1 
ATOM   594  C  CA  . LYS A 1 113 ? 124.767 137.313 155.046 1.00 67.02 ? 113 LYS A CA  1 
ATOM   595  C  C   . LYS A 1 113 ? 125.512 136.374 154.113 1.00 67.02 ? 113 LYS A C   1 
ATOM   596  O  O   . LYS A 1 113 ? 125.512 135.163 154.317 1.00 67.02 ? 113 LYS A O   1 
ATOM   597  C  CB  . LYS A 1 113 ? 124.478 138.642 154.351 1.00 67.02 ? 113 LYS A CB  1 
ATOM   598  C  CG  . LYS A 1 113 ? 125.712 139.333 153.843 1.00 67.02 ? 113 LYS A CG  1 
ATOM   599  C  CD  . LYS A 1 113 ? 125.390 140.673 153.213 1.00 67.02 ? 113 LYS A CD  1 
ATOM   600  C  CE  . LYS A 1 113 ? 126.649 141.322 152.663 1.00 67.02 ? 113 LYS A CE  1 
ATOM   601  N  NZ  . LYS A 1 113 ? 126.373 142.629 152.020 1.00 67.02 ? 113 LYS A NZ  1 
ATOM   602  N  N   . SER A 1 114 ? 118.939 122.519 142.514 1.00 97.70 ? 114 SER A N   1 
ATOM   603  C  CA  . SER A 1 114 ? 119.977 123.532 142.358 1.00 97.70 ? 114 SER A CA  1 
ATOM   604  C  C   . SER A 1 114 ? 120.529 123.531 140.935 1.00 97.70 ? 114 SER A C   1 
ATOM   605  O  O   . SER A 1 114 ? 120.888 122.481 140.401 1.00 97.70 ? 114 SER A O   1 
ATOM   606  C  CB  . SER A 1 114 ? 121.098 123.306 143.367 1.00 97.70 ? 114 SER A CB  1 
ATOM   607  N  N   . PHE A 1 115 ? 120.599 124.718 140.327 1.00 98.19 ? 115 PHE A N   1 
ATOM   608  C  CA  . PHE A 1 115 ? 121.067 124.866 138.953 1.00 98.19 ? 115 PHE A CA  1 
ATOM   609  C  C   . PHE A 1 115 ? 122.432 125.539 138.873 1.00 98.19 ? 115 PHE A C   1 
ATOM   610  O  O   . PHE A 1 115 ? 122.911 125.807 137.763 1.00 98.19 ? 115 PHE A O   1 
ATOM   611  C  CB  . PHE A 1 115 ? 120.042 125.650 138.125 1.00 98.19 ? 115 PHE A CB  1 
ATOM   612  C  CG  . PHE A 1 115 ? 118.756 124.903 137.873 1.00 98.19 ? 115 PHE A CG  1 
ATOM   613  C  CD1 . PHE A 1 115 ? 118.697 123.520 137.990 1.00 98.19 ? 115 PHE A CD1 1 
ATOM   614  C  CD2 . PHE A 1 115 ? 117.599 125.591 137.539 1.00 98.19 ? 115 PHE A CD2 1 
ATOM   615  C  CE1 . PHE A 1 115 ? 117.513 122.837 137.768 1.00 98.19 ? 115 PHE A CE1 1 
ATOM   616  C  CE2 . PHE A 1 115 ? 116.410 124.915 137.315 1.00 98.19 ? 115 PHE A CE2 1 
ATOM   617  C  CZ  . PHE A 1 115 ? 116.369 123.537 137.430 1.00 98.19 ? 115 PHE A CZ  1 
ATOM   618  N  N   . LYS A 1 116 ? 123.049 125.824 140.024 1.00 95.16 ? 116 LYS A N   1 
ATOM   619  C  CA  . LYS A 1 116 ? 124.425 126.308 140.164 1.00 95.16 ? 116 LYS A CA  1 
ATOM   620  C  C   . LYS A 1 116 ? 124.641 127.634 139.442 1.00 95.16 ? 116 LYS A C   1 
ATOM   621  O  O   . LYS A 1 116 ? 125.618 127.835 138.720 1.00 95.16 ? 116 LYS A O   1 
ATOM   622  C  CB  . LYS A 1 116 ? 125.433 125.255 139.695 1.00 95.16 ? 116 LYS A CB  1 
ATOM   623  C  CG  . LYS A 1 116 ? 125.406 123.923 140.461 1.00 95.16 ? 116 LYS A CG  1 
ATOM   624  C  CD  . LYS A 1 116 ? 126.027 124.008 141.859 1.00 95.16 ? 116 LYS A CD  1 
ATOM   625  C  CE  . LYS A 1 116 ? 124.991 124.074 142.982 1.00 95.16 ? 116 LYS A CE  1 
ATOM   626  N  NZ  . LYS A 1 116 ? 125.651 124.089 144.317 1.00 95.16 ? 116 LYS A NZ  1 
ATOM   627  N  N   . ASN A 1 117 ? 123.705 128.553 139.662 1.00 93.12 ? 117 ASN A N   1 
ATOM   628  C  CA  . ASN A 1 117 ? 123.848 129.902 139.136 1.00 93.12 ? 117 ASN A CA  1 
ATOM   629  C  C   . ASN A 1 117 ? 124.674 130.803 140.045 1.00 93.12 ? 117 ASN A C   1 
ATOM   630  O  O   . ASN A 1 117 ? 124.695 132.019 139.832 1.00 93.12 ? 117 ASN A O   1 
ATOM   631  C  CB  . ASN A 1 117 ? 122.472 130.534 138.901 1.00 93.12 ? 117 ASN A CB  1 
ATOM   632  C  CG  . ASN A 1 117 ? 121.668 129.813 137.836 1.00 93.12 ? 117 ASN A CG  1 
ATOM   633  O  OD1 . ASN A 1 117 ? 120.624 129.229 138.122 1.00 93.12 ? 117 ASN A OD1 1 
ATOM   634  N  ND2 . ASN A 1 117 ? 122.148 129.855 136.598 1.00 93.12 ? 117 ASN A ND2 1 
ATOM   635  N  N   . HIS A 1 118 ? 125.339 130.247 141.055 1.00 82.03 ? 118 HIS A N   1 
ATOM   636  C  CA  . HIS A 1 118 ? 126.114 131.056 141.988 1.00 82.03 ? 118 HIS A CA  1 
ATOM   637  C  C   . HIS A 1 118 ? 127.449 131.391 141.348 1.00 82.03 ? 118 HIS A C   1 
ATOM   638  O  O   . HIS A 1 118 ? 128.448 130.694 141.529 1.00 82.03 ? 118 HIS A O   1 
ATOM   639  C  CB  . HIS A 1 118 ? 126.306 130.342 143.315 1.00 82.03 ? 118 HIS A CB  1 
ATOM   640  C  CG  . HIS A 1 118 ? 127.099 131.141 144.293 1.00 82.03 ? 118 HIS A CG  1 
ATOM   641  N  ND1 . HIS A 1 118 ? 126.613 132.289 144.878 1.00 82.03 ? 118 HIS A ND1 1 
ATOM   642  C  CD2 . HIS A 1 118 ? 128.351 130.972 144.771 1.00 82.03 ? 118 HIS A CD2 1 
ATOM   643  C  CE1 . HIS A 1 118 ? 127.532 132.791 145.683 1.00 82.03 ? 118 HIS A CE1 1 
ATOM   644  N  NE2 . HIS A 1 118 ? 128.596 132.009 145.637 1.00 82.03 ? 118 HIS A NE2 1 
ATOM   645  N  N   . VAL A 1 119 ? 127.455 132.476 140.581 1.00 73.27 ? 119 VAL A N   1 
ATOM   646  C  CA  . VAL A 1 119 ? 128.655 133.005 139.952 1.00 73.27 ? 119 VAL A CA  1 
ATOM   647  C  C   . VAL A 1 119 ? 128.773 134.466 140.351 1.00 73.27 ? 119 VAL A C   1 
ATOM   648  O  O   . VAL A 1 119 ? 127.944 135.288 139.949 1.00 73.27 ? 119 VAL A O   1 
ATOM   649  C  CB  . VAL A 1 119 ? 128.617 132.866 138.423 1.00 73.27 ? 119 VAL A CB  1 
ATOM   650  C  CG1 . VAL A 1 119 ? 129.814 133.527 137.817 1.00 73.27 ? 119 VAL A CG1 1 
ATOM   651  C  CG2 . VAL A 1 119 ? 128.582 131.409 138.023 1.00 73.27 ? 119 VAL A CG2 1 
ATOM   652  N  N   . ILE A 1 120 ? 129.787 134.789 141.148 1.00 63.93 ? 120 ILE A N   1 
ATOM   653  C  CA  . ILE A 1 120 ? 130.091 136.166 141.516 1.00 63.93 ? 120 ILE A CA  1 
ATOM   654  C  C   . ILE A 1 120 ? 131.074 136.723 140.506 1.00 63.93 ? 120 ILE A C   1 
ATOM   655  O  O   . ILE A 1 120 ? 132.168 136.179 140.327 1.00 63.93 ? 120 ILE A O   1 
ATOM   656  C  CB  . ILE A 1 120 ? 130.662 136.260 142.938 1.00 63.93 ? 120 ILE A CB  1 
ATOM   657  C  CG1 . ILE A 1 120 ? 129.619 135.807 143.950 1.00 63.93 ? 120 ILE A CG1 1 
ATOM   658  C  CG2 . ILE A 1 120 ? 131.116 137.659 143.225 1.00 63.93 ? 120 ILE A CG2 1 
ATOM   659  C  CD1 . ILE A 1 120 ? 128.354 136.611 143.893 1.00 63.93 ? 120 ILE A CD1 1 
ATOM   660  N  N   . GLN A 1 121 ? 130.687 137.807 139.853 1.00 58.10 ? 121 GLN A N   1 
ATOM   661  C  CA  . GLN A 1 121 ? 131.492 138.491 138.860 1.00 58.10 ? 121 GLN A CA  1 
ATOM   662  C  C   . GLN A 1 121 ? 131.949 139.833 139.417 1.00 58.10 ? 121 GLN A C   1 
ATOM   663  O  O   . GLN A 1 121 ? 131.532 140.245 140.498 1.00 58.10 ? 121 GLN A O   1 
ATOM   664  C  CB  . GLN A 1 121 ? 130.699 138.602 137.557 1.00 58.10 ? 121 GLN A CB  1 
ATOM   665  C  CG  . GLN A 1 121 ? 129.279 139.060 137.755 1.00 58.10 ? 121 GLN A CG  1 
ATOM   666  C  CD  . GLN A 1 121 ? 128.436 138.859 136.524 1.00 58.10 ? 121 GLN A CD  1 
ATOM   667  O  OE1 . GLN A 1 121 ? 128.935 138.496 135.468 1.00 58.10 ? 121 GLN A OE1 1 
ATOM   668  N  NE2 . GLN A 1 121 ? 127.137 139.057 136.665 1.00 58.10 ? 121 GLN A NE2 1 
ATOM   669  N  N   . TRP A 1 122 ? 132.869 140.537 138.837 1.00 53.09 ? 122 TRP A N   1 
ATOM   670  C  CA  . TRP A 1 122 ? 133.442 141.734 139.489 1.00 53.09 ? 122 TRP A CA  1 
ATOM   671  C  C   . TRP A 1 122 ? 132.603 142.849 139.960 1.00 53.09 ? 122 TRP A C   1 
ATOM   672  O  O   . TRP A 1 122 ? 132.994 143.608 140.865 1.00 53.09 ? 122 TRP A O   1 
ATOM   673  C  CB  . TRP A 1 122 ? 134.447 142.326 138.481 1.00 53.09 ? 122 TRP A CB  1 
ATOM   674  C  CG  . TRP A 1 122 ? 135.319 143.494 138.697 1.00 53.09 ? 122 TRP A CG  1 
ATOM   675  C  CD1 . TRP A 1 122 ? 135.552 144.456 137.785 1.00 53.09 ? 122 TRP A CD1 1 
ATOM   676  C  CD2 . TRP A 1 122 ? 136.179 143.778 139.803 1.00 53.09 ? 122 TRP A CD2 1 
ATOM   677  N  NE1 . TRP A 1 122 ? 136.445 145.361 138.262 1.00 53.09 ? 122 TRP A NE1 1 
ATOM   678  C  CE2 . TRP A 1 122 ? 136.848 144.969 139.506 1.00 53.09 ? 122 TRP A CE2 1 
ATOM   679  C  CE3 . TRP A 1 122 ? 136.418 143.169 141.029 1.00 53.09 ? 122 TRP A CE3 1 
ATOM   680  C  CZ2 . TRP A 1 122 ? 137.737 145.565 140.383 1.00 53.09 ? 122 TRP A CZ2 1 
ATOM   681  C  CZ3 . TRP A 1 122 ? 137.309 143.767 141.898 1.00 53.09 ? 122 TRP A CZ3 1 
ATOM   682  C  CH2 . TRP A 1 122 ? 137.950 144.952 141.573 1.00 53.09 ? 122 TRP A CH2 1 
ATOM   683  N  N   . PHE A 1 123 ? 131.427 142.989 139.465 1.00 56.70 ? 123 PHE A N   1 
ATOM   684  C  CA  . PHE A 1 123 ? 130.695 144.187 139.773 1.00 56.70 ? 123 PHE A CA  1 
ATOM   685  C  C   . PHE A 1 123 ? 130.149 144.124 141.149 1.00 56.70 ? 123 PHE A C   1 
ATOM   686  O  O   . PHE A 1 123 ? 130.067 145.131 141.831 1.00 56.70 ? 123 PHE A O   1 
ATOM   687  C  CB  . PHE A 1 123 ? 129.657 144.363 138.706 1.00 56.70 ? 123 PHE A CB  1 
ATOM   688  C  CG  . PHE A 1 123 ? 130.218 144.132 137.338 1.00 56.70 ? 123 PHE A CG  1 
ATOM   689  C  CD1 . PHE A 1 123 ? 131.251 144.923 136.873 1.00 56.70 ? 123 PHE A CD1 1 
ATOM   690  C  CD2 . PHE A 1 123 ? 129.791 143.077 136.559 1.00 56.70 ? 123 PHE A CD2 1 
ATOM   691  C  CE1 . PHE A 1 123 ? 131.817 144.696 135.643 1.00 56.70 ? 123 PHE A CE1 1 
ATOM   692  C  CE2 . PHE A 1 123 ? 130.355 142.847 135.321 1.00 56.70 ? 123 PHE A CE2 1 
ATOM   693  C  CZ  . PHE A 1 123 ? 131.370 143.658 134.867 1.00 56.70 ? 123 PHE A CZ  1 
ATOM   694  N  N   . GLU A 1 124 ? 129.846 142.934 141.615 1.00 57.30 ? 124 GLU A N   1 
ATOM   695  C  CA  . GLU A 1 124 ? 129.336 142.785 142.940 1.00 57.30 ? 124 GLU A CA  1 
ATOM   696  C  C   . GLU A 1 124 ? 130.438 143.033 143.923 1.00 57.30 ? 124 GLU A C   1 
ATOM   697  O  O   . GLU A 1 124 ? 130.164 143.523 144.988 1.00 57.30 ? 124 GLU A O   1 
ATOM   698  C  CB  . GLU A 1 124 ? 128.768 141.420 143.091 1.00 57.30 ? 124 GLU A CB  1 
ATOM   699  C  CG  . GLU A 1 124 ? 127.957 141.226 144.352 1.00 57.30 ? 124 GLU A CG  1 
ATOM   700  C  CD  . GLU A 1 124 ? 126.713 140.384 144.133 1.00 57.30 ? 124 GLU A CD  1 
ATOM   701  O  OE1 . GLU A 1 124 ? 126.523 139.893 142.999 1.00 57.30 ? 124 GLU A OE1 1 
ATOM   702  O  OE2 . GLU A 1 124 ? 125.925 140.211 145.092 1.00 57.30 ? 124 GLU A OE2 1 
ATOM   703  N  N   . VAL A 1 125 ? 131.683 142.731 143.591 1.00 52.74 ? 125 VAL A N   1 
ATOM   704  C  CA  . VAL A 1 125 ? 132.829 142.962 144.438 1.00 52.74 ? 125 VAL A CA  1 
ATOM   705  C  C   . VAL A 1 125 ? 133.047 144.393 144.510 1.00 52.74 ? 125 VAL A C   1 
ATOM   706  O  O   . VAL A 1 125 ? 133.377 144.878 145.550 1.00 52.74 ? 125 VAL A O   1 
ATOM   707  C  CB  . VAL A 1 125 ? 134.073 142.345 143.898 1.00 52.74 ? 125 VAL A CB  1 
ATOM   708  C  CG1 . VAL A 1 125 ? 135.293 142.785 144.669 1.00 52.74 ? 125 VAL A CG1 1 
ATOM   709  C  CG2 . VAL A 1 125 ? 133.955 140.836 143.892 1.00 52.74 ? 125 VAL A CG2 1 
ATOM   710  N  N   . LEU A 1 126 ? 132.810 145.131 143.438 1.00 52.67 ? 126 LEU A N   1 
ATOM   711  C  CA  . LEU A 1 126 ? 132.948 146.615 143.546 1.00 52.67 ? 126 LEU A CA  1 
ATOM   712  C  C   . LEU A 1 126 ? 131.793 147.200 144.327 1.00 52.67 ? 126 LEU A C   1 
ATOM   713  O  O   . LEU A 1 126 ? 131.998 148.200 144.975 1.00 52.67 ? 126 LEU A O   1 
ATOM   714  C  CB  . LEU A 1 126 ? 133.139 147.311 142.218 1.00 52.67 ? 126 LEU A CB  1 
ATOM   715  C  CG  . LEU A 1 126 ? 134.471 147.265 141.533 1.00 52.67 ? 126 LEU A CG  1 
ATOM   716  C  CD1 . LEU A 1 126 ? 134.203 147.634 140.093 1.00 52.67 ? 126 LEU A CD1 1 
ATOM   717  C  CD2 . LEU A 1 126 ? 135.389 148.271 142.180 1.00 52.67 ? 126 LEU A CD2 1 
ATOM   718  N  N   . ASP A 1 127 ? 130.600 146.599 144.322 1.00 56.38 ? 127 ASP A N   1 
ATOM   719  C  CA  . ASP A 1 127 ? 129.494 147.059 145.210 1.00 56.38 ? 127 ASP A CA  1 
ATOM   720  C  C   . ASP A 1 127 ? 129.606 146.822 146.740 1.00 56.38 ? 127 ASP A C   1 
ATOM   721  O  O   . ASP A 1 127 ? 129.422 147.761 147.470 1.00 56.38 ? 127 ASP A O   1 
ATOM   722  C  CB  . ASP A 1 127 ? 128.218 146.387 144.857 1.00 56.38 ? 127 ASP A CB  1 
ATOM   723  C  CG  . ASP A 1 127 ? 127.043 147.097 145.390 1.00 56.38 ? 127 ASP A CG  1 
ATOM   724  O  OD1 . ASP A 1 127 ? 127.014 148.336 145.288 1.00 56.38 ? 127 ASP A OD1 1 
ATOM   725  O  OD2 . ASP A 1 127 ? 126.143 146.417 145.911 1.00 56.38 ? 127 ASP A OD2 1 
ATOM   726  N  N   . GLY A 1 128 ? 129.871 145.621 147.250 1.00 53.49 ? 128 GLY A N   1 
ATOM   727  C  CA  . GLY A 1 128 ? 130.061 145.343 148.659 1.00 53.49 ? 128 GLY A CA  1 
ATOM   728  C  C   . GLY A 1 128 ? 131.073 146.303 149.241 1.00 53.49 ? 128 GLY A C   1 
ATOM   729  O  O   . GLY A 1 128 ? 130.937 146.695 150.402 1.00 53.49 ? 128 GLY A O   1 
ATOM   730  N  N   . LEU A 1 129 ? 132.066 146.708 148.461 1.00 51.39 ? 129 LEU A N   1 
ATOM   731  C  CA  . LEU A 1 129 ? 133.096 147.607 148.950 1.00 51.39 ? 129 LEU A CA  1 
ATOM   732  C  C   . LEU A 1 129 ? 132.753 149.071 148.730 1.00 51.39 ? 129 LEU A C   1 
ATOM   733  O  O   . LEU A 1 129 ? 132.758 149.849 149.686 1.00 51.39 ? 129 LEU A O   1 
ATOM   734  C  CB  . LEU A 1 129 ? 134.408 147.180 148.303 1.00 51.39 ? 129 LEU A CB  1 
ATOM   735  C  CG  . LEU A 1 129 ? 134.854 145.763 148.597 1.00 51.39 ? 129 LEU A CG  1 
ATOM   736  C  CD1 . LEU A 1 129 ? 136.081 145.451 147.780 1.00 51.39 ? 129 LEU A CD1 1 
ATOM   737  C  CD2 . LEU A 1 129 ? 135.143 145.634 150.053 1.00 51.39 ? 129 LEU A CD2 1 
ATOM   738  N  N   . LEU A 1 130 ? 132.449 149.476 147.499 1.00 51.57 ? 130 LEU A N   1 
ATOM   739  C  CA  . LEU A 1 130 ? 132.358 150.894 147.186 1.00 51.57 ? 130 LEU A CA  1 
ATOM   740  C  C   . LEU A 1 130 ? 130.999 151.481 146.830 1.00 51.57 ? 130 LEU A C   1 
ATOM   741  O  O   . LEU A 1 130 ? 130.930 152.686 146.576 1.00 51.57 ? 130 LEU A O   1 
ATOM   742  C  CB  . LEU A 1 130 ? 133.329 151.114 146.021 1.00 51.57 ? 130 LEU A CB  1 
ATOM   743  C  CG  . LEU A 1 130 ? 134.807 150.882 146.350 1.00 51.57 ? 130 LEU A CG  1 
ATOM   744  C  CD1 . LEU A 1 130 ? 135.666 150.970 145.114 1.00 51.57 ? 130 LEU A CD1 1 
ATOM   745  C  CD2 . LEU A 1 130 ? 135.283 151.871 147.392 1.00 51.57 ? 130 LEU A CD2 1 
ATOM   746  N  N   . GLY A 1 131 ? 129.938 150.689 146.759 1.00 54.47 ? 131 GLY A N   1 
ATOM   747  C  CA  . GLY A 1 131 ? 128.613 151.228 147.010 1.00 54.47 ? 131 GLY A CA  1 
ATOM   748  C  C   . GLY A 1 131 ? 127.893 152.034 145.949 1.00 54.47 ? 131 GLY A C   1 
ATOM   749  O  O   . GLY A 1 131 ? 127.689 153.237 146.126 1.00 54.47 ? 131 GLY A O   1 
ATOM   750  N  N   . SER A 1 132 ? 127.566 151.403 144.820 1.00 58.27 ? 132 SER A N   1 
ATOM   751  C  CA  . SER A 1 132 ? 126.568 151.842 143.839 1.00 58.27 ? 132 SER A CA  1 
ATOM   752  C  C   . SER A 1 132 ? 126.924 153.097 143.041 1.00 58.27 ? 132 SER A C   1 
ATOM   753  O  O   . SER A 1 132 ? 126.210 153.445 142.096 1.00 58.27 ? 132 SER A O   1 
ATOM   754  C  CB  . SER A 1 132 ? 125.208 152.045 144.517 1.00 58.27 ? 132 SER A CB  1 
ATOM   755  O  OG  . SER A 1 132 ? 124.719 150.828 145.045 1.00 58.27 ? 132 SER A OG  1 
ATOM   756  N  N   . TYR A 1 133 ? 128.014 153.777 143.380 1.00 57.27 ? 133 TYR A N   1 
ATOM   757  C  CA  . TYR A 1 133 ? 128.645 154.693 142.442 1.00 57.27 ? 133 TYR A CA  1 
ATOM   758  C  C   . TYR A 1 133 ? 129.710 153.993 141.624 1.00 57.27 ? 133 TYR A C   1 
ATOM   759  O  O   . TYR A 1 133 ? 130.057 154.469 140.541 1.00 57.27 ? 133 TYR A O   1 
ATOM   760  C  CB  . TYR A 1 133 ? 129.296 155.875 143.167 1.00 57.27 ? 133 TYR A CB  1 
ATOM   761  C  CG  . TYR A 1 133 ? 128.350 156.841 143.831 1.00 57.27 ? 133 TYR A CG  1 
ATOM   762  C  CD1 . TYR A 1 133 ? 127.010 156.907 143.467 1.00 57.27 ? 133 TYR A CD1 1 
ATOM   763  C  CD2 . TYR A 1 133 ? 128.801 157.680 144.841 1.00 57.27 ? 133 TYR A CD2 1 
ATOM   764  C  CE1 . TYR A 1 133 ? 126.146 157.794 144.090 1.00 57.27 ? 133 TYR A CE1 1 
ATOM   765  C  CE2 . TYR A 1 133 ? 127.947 158.565 145.472 1.00 57.27 ? 133 TYR A CE2 1 
ATOM   766  C  CZ  . TYR A 1 133 ? 126.623 158.619 145.094 1.00 57.27 ? 133 TYR A CZ  1 
ATOM   767  O  OH  . TYR A 1 133 ? 125.782 159.504 145.727 1.00 57.27 ? 133 TYR A OH  1 
ATOM   768  N  N   . TRP A 1 134 ? 130.230 152.879 142.130 1.00 52.04 ? 134 TRP A N   1 
ATOM   769  C  CA  . TRP A 1 134 ? 131.282 152.111 141.494 1.00 52.04 ? 134 TRP A CA  1 
ATOM   770  C  C   . TRP A 1 134 ? 130.765 150.833 140.875 1.00 52.04 ? 134 TRP A C   1 
ATOM   771  O  O   . TRP A 1 134 ? 131.551 150.059 140.331 1.00 52.04 ? 134 TRP A O   1 
ATOM   772  C  CB  . TRP A 1 134 ? 132.368 151.801 142.508 1.00 52.04 ? 134 TRP A CB  1 
ATOM   773  C  CG  . TRP A 1 134 ? 133.180 152.978 142.838 1.00 52.04 ? 134 TRP A CG  1 
ATOM   774  C  CD1 . TRP A 1 134 ? 132.961 153.877 143.831 1.00 52.04 ? 134 TRP A CD1 1 
ATOM   775  C  CD2 . TRP A 1 134 ? 134.375 153.380 142.185 1.00 52.04 ? 134 TRP A CD2 1 
ATOM   776  N  NE1 . TRP A 1 134 ? 133.941 154.832 143.828 1.00 52.04 ? 134 TRP A NE1 1 
ATOM   777  C  CE2 . TRP A 1 134 ? 134.825 154.545 142.824 1.00 52.04 ? 134 TRP A CE2 1 
ATOM   778  C  CE3 . TRP A 1 134 ? 135.109 152.869 141.113 1.00 52.04 ? 134 TRP A CE3 1 
ATOM   779  C  CZ2 . TRP A 1 134 ? 135.968 155.212 142.424 1.00 52.04 ? 134 TRP A CZ2 1 
ATOM   780  C  CZ3 . TRP A 1 134 ? 136.243 153.527 140.720 1.00 52.04 ? 134 TRP A CZ3 1 
ATOM   781  C  CH2 . TRP A 1 134 ? 136.667 154.688 141.374 1.00 52.04 ? 134 TRP A CH2 1 
ATOM   782  N  N   . LYS A 1 135 ? 129.469 150.579 140.967 1.00 52.92 ? 135 LYS A N   1 
ATOM   783  C  CA  . LYS A 1 135 ? 128.865 149.541 140.152 1.00 52.92 ? 135 LYS A CA  1 
ATOM   784  C  C   . LYS A 1 135 ? 128.584 150.045 138.755 1.00 52.92 ? 135 LYS A C   1 
ATOM   785  O  O   . LYS A 1 135 ? 128.902 149.365 137.781 1.00 52.92 ? 135 LYS A O   1 
ATOM   786  C  CB  . LYS A 1 135 ? 127.560 149.049 140.764 1.00 52.92 ? 135 LYS A CB  1 
ATOM   787  C  CG  . LYS A 1 135 ? 126.937 147.922 139.972 1.00 52.92 ? 135 LYS A CG  1 
ATOM   788  C  CD  . LYS A 1 135 ? 125.640 147.469 140.585 1.00 52.92 ? 135 LYS A CD  1 
ATOM   789  C  CE  . LYS A 1 135 ? 125.009 146.379 139.754 1.00 52.92 ? 135 LYS A CE  1 
ATOM   790  N  NZ  . LYS A 1 135 ? 125.831 145.152 139.815 1.00 52.92 ? 135 LYS A NZ  1 
ATOM   791  N  N   . ALA A 1 136 ? 127.989 151.233 138.651 1.00 50.70 ? 136 ALA A N   1 
ATOM   792  C  CA  . ALA A 1 136 ? 127.650 151.795 137.354 1.00 50.70 ? 136 ALA A CA  1 
ATOM   793  C  C   . ALA A 1 136 ? 128.886 152.139 136.541 1.00 50.70 ? 136 ALA A C   1 
ATOM   794  O  O   . ALA A 1 136 ? 128.934 151.852 135.341 1.00 50.70 ? 136 ALA A O   1 
ATOM   795  C  CB  . ALA A 1 136 ? 126.790 153.038 137.543 1.00 50.70 ? 136 ALA A CB  1 
ATOM   796  N  N   . LEU A 1 137 ? 129.897 152.728 137.178 1.00 51.22 ? 137 LEU A N   1 
ATOM   797  C  CA  . LEU A 1 137 ? 131.093 153.138 136.454 1.00 51.22 ? 137 LEU A CA  1 
ATOM   798  C  C   . LEU A 1 137 ? 131.925 151.929 136.048 1.00 51.22 ? 137 LEU A C   1 
ATOM   799  O  O   . LEU A 1 137 ? 132.594 151.942 135.014 1.00 51.22 ? 137 LEU A O   1 
ATOM   800  C  CB  . LEU A 1 137 ? 131.911 154.098 137.309 1.00 51.22 ? 137 LEU A CB  1 
ATOM   801  C  CG  . LEU A 1 137 ? 133.085 154.769 136.614 1.00 51.22 ? 137 LEU A CG  1 
ATOM   802  C  CD1 . LEU A 1 137 ? 132.576 155.639 135.487 1.00 51.22 ? 137 LEU A CD1 1 
ATOM   803  C  CD2 . LEU A 1 137 ? 133.884 155.583 137.609 1.00 51.22 ? 137 LEU A CD2 1 
ATOM   804  N  N   . GLY A 1 138 ? 131.883 150.871 136.835 1.00 52.28 ? 138 GLY A N   1 
ATOM   805  C  CA  . GLY A 1 138 ? 132.568 149.665 136.443 1.00 52.28 ? 138 GLY A CA  1 
ATOM   806  C  C   . GLY A 1 138 ? 131.805 148.786 135.487 1.00 52.28 ? 138 GLY A C   1 
ATOM   807  O  O   . GLY A 1 138 ? 132.376 147.819 134.979 1.00 52.28 ? 138 GLY A O   1 
ATOM   808  N  N   . LEU A 1 139 ? 130.531 149.075 135.242 1.00 49.67 ? 139 LEU A N   1 
ATOM   809  C  CA  . LEU A 1 139 ? 129.734 148.315 134.294 1.00 49.67 ? 139 LEU A CA  1 
ATOM   810  C  C   . LEU A 1 139 ? 129.509 149.073 132.992 1.00 49.67 ? 139 LEU A C   1 
ATOM   811  O  O   . LEU A 1 139 ? 129.029 148.483 132.018 1.00 49.67 ? 139 LEU A O   1 
ATOM   812  C  CB  . LEU A 1 139 ? 128.393 147.928 134.939 1.00 49.67 ? 139 LEU A CB  1 
ATOM   813  C  CG  . LEU A 1 139 ? 127.370 146.957 134.349 1.00 49.67 ? 139 LEU A CG  1 
ATOM   814  C  CD1 . LEU A 1 139 ? 127.962 145.589 134.218 1.00 49.67 ? 139 LEU A CD1 1 
ATOM   815  C  CD2 . LEU A 1 139 ? 126.142 146.899 135.231 1.00 49.67 ? 139 LEU A CD2 1 
ATOM   816  N  N   . ALA A 1 140 ? 129.850 150.362 132.947 1.00 48.16 ? 140 ALA A N   1 
ATOM   817  C  CA  . ALA A 1 140 ? 129.872 151.086 131.682 1.00 48.16 ? 140 ALA A CA  1 
ATOM   818  C  C   . ALA A 1 140 ? 131.118 150.737 130.876 1.00 48.16 ? 140 ALA A C   1 
ATOM   819  O  O   . ALA A 1 140 ? 131.030 150.393 129.695 1.00 48.16 ? 140 ALA A O   1 
ATOM   820  C  CB  . ALA A 1 140 ? 129.797 152.589 131.938 1.00 48.16 ? 140 ALA A CB  1 
ATOM   821  N  N   . PHE A 1 141 ? 132.294 150.797 131.506 1.00 49.58 ? 141 PHE A N   1 
ATOM   822  C  CA  . PHE A 1 141 ? 133.538 150.467 130.819 1.00 49.58 ? 141 PHE A CA  1 
ATOM   823  C  C   . PHE A 1 141 ? 133.710 148.985 130.549 1.00 49.58 ? 141 PHE A C   1 
ATOM   824  O  O   . PHE A 1 141 ? 134.672 148.615 129.874 1.00 49.58 ? 141 PHE A O   1 
ATOM   825  C  CB  . PHE A 1 141 ? 134.762 150.901 131.616 1.00 49.58 ? 141 PHE A CB  1 
ATOM   826  C  CG  . PHE A 1 141 ? 134.921 152.368 131.747 1.00 49.58 ? 141 PHE A CG  1 
ATOM   827  C  CD1 . PHE A 1 141 ? 135.243 153.137 130.652 1.00 49.58 ? 141 PHE A CD1 1 
ATOM   828  C  CD2 . PHE A 1 141 ? 134.845 152.965 132.983 1.00 49.58 ? 141 PHE A CD2 1 
ATOM   829  C  CE1 . PHE A 1 141 ? 135.414 154.491 130.776 1.00 49.58 ? 141 PHE A CE1 1 
ATOM   830  C  CE2 . PHE A 1 141 ? 135.021 154.310 133.117 1.00 49.58 ? 141 PHE A CE2 1 
ATOM   831  C  CZ  . PHE A 1 141 ? 135.305 155.079 132.011 1.00 49.58 ? 141 PHE A CZ  1 
ATOM   832  N  N   . ASN A 1 142 ? 132.819 148.153 131.010 1.00 49.50 ? 142 ASN A N   1 
ATOM   833  C  CA  . ASN A 1 142 ? 132.992 146.718 130.829 1.00 49.50 ? 142 ASN A CA  1 
ATOM   834  C  C   . ASN A 1 142 ? 131.988 146.217 129.842 1.00 49.50 ? 142 ASN A C   1 
ATOM   835  O  O   . ASN A 1 142 ? 132.225 145.227 129.194 1.00 49.50 ? 142 ASN A O   1 
ATOM   836  C  CB  . ASN A 1 142 ? 133.069 145.950 132.120 1.00 49.50 ? 142 ASN A CB  1 
ATOM   837  C  CG  . ASN A 1 142 ? 133.801 144.641 131.977 1.00 49.50 ? 142 ASN A CG  1 
ATOM   838  O  OD1 . ASN A 1 142 ? 135.020 144.591 132.021 1.00 49.50 ? 142 ASN A OD1 1 
ATOM   839  N  ND2 . ASN A 1 142 ? 133.055 143.571 131.796 1.00 49.50 ? 142 ASN A ND2 1 
ATOM   840  N  N   . CYS A 1 143 ? 130.830 146.821 129.760 1.00 51.03 ? 143 CYS A N   1 
ATOM   841  C  CA  . CYS A 1 143 ? 129.900 146.514 128.688 1.00 51.03 ? 143 CYS A CA  1 
ATOM   842  C  C   . CYS A 1 143 ? 130.121 147.162 127.335 1.00 51.03 ? 143 CYS A C   1 
ATOM   843  O  O   . CYS A 1 143 ? 129.880 146.515 126.317 1.00 51.03 ? 143 CYS A O   1 
ATOM   844  C  CB  . CYS A 1 143 ? 128.494 146.508 129.293 1.00 51.03 ? 143 CYS A CB  1 
ATOM   845  S  SG  . CYS A 1 143 ? 128.275 145.266 130.567 1.00 51.03 ? 143 CYS A SG  1 
ATOM   846  N  N   . THR A 1 144 ? 130.535 148.424 127.287 1.00 46.37 ? 144 THR A N   1 
ATOM   847  C  CA  . THR A 1 144 ? 131.089 148.951 126.050 1.00 46.37 ? 144 THR A CA  1 
ATOM   848  C  C   . THR A 1 144 ? 132.407 148.474 125.477 1.00 46.37 ? 144 THR A C   1 
ATOM   849  O  O   . THR A 1 144 ? 132.584 148.487 124.257 1.00 46.37 ? 144 THR A O   1 
ATOM   850  C  CB  . THR A 1 144 ? 130.923 150.466 126.088 1.00 46.37 ? 144 THR A CB  1 
ATOM   851  O  OG1 . THR A 1 144 ? 131.914 151.027 126.945 1.00 46.37 ? 144 THR A OG1 1 
ATOM   852  C  CG2 . THR A 1 144 ? 129.540 150.835 126.590 1.00 46.37 ? 144 THR A CG2 1 
ATOM   853  N  N   . PHE A 1 145 ? 133.355 148.100 126.335 1.00 46.11 ? 145 PHE A N   1 
ATOM   854  C  CA  . PHE A 1 145 ? 134.469 147.286 125.873 1.00 46.11 ? 145 PHE A CA  1 
ATOM   855  C  C   . PHE A 1 145 ? 134.096 145.980 125.210 1.00 46.11 ? 145 PHE A C   1 
ATOM   856  O  O   . PHE A 1 145 ? 134.631 145.660 124.149 1.00 46.11 ? 145 PHE A O   1 
ATOM   857  C  CB  . PHE A 1 145 ? 135.493 147.030 126.975 1.00 46.11 ? 145 PHE A CB  1 
ATOM   858  C  CG  . PHE A 1 145 ? 136.539 146.018 126.598 1.00 46.11 ? 145 PHE A CG  1 
ATOM   859  C  CD1 . PHE A 1 145 ? 137.503 146.305 125.651 1.00 46.11 ? 145 PHE A CD1 1 
ATOM   860  C  CD2 . PHE A 1 145 ? 136.555 144.769 127.194 1.00 46.11 ? 145 PHE A CD2 1 
ATOM   861  C  CE1 . PHE A 1 145 ? 138.450 145.359 125.303 1.00 46.11 ? 145 PHE A CE1 1 
ATOM   862  C  CE2 . PHE A 1 145 ? 137.506 143.827 126.850 1.00 46.11 ? 145 PHE A CE2 1 
ATOM   863  C  CZ  . PHE A 1 145 ? 138.456 144.124 125.912 1.00 46.11 ? 145 PHE A CZ  1 
ATOM   864  N  N   . LEU A 1 146 ? 133.177 145.221 125.796 1.00 47.23 ? 146 LEU A N   1 
ATOM   865  C  CA  . LEU A 1 146 ? 132.807 143.942 125.212 1.00 47.23 ? 146 LEU A CA  1 
ATOM   866  C  C   . LEU A 1 146 ? 131.991 144.076 123.941 1.00 47.23 ? 146 LEU A C   1 
ATOM   867  O  O   . LEU A 1 146 ? 131.801 143.075 123.253 1.00 47.23 ? 146 LEU A O   1 
ATOM   868  C  CB  . LEU A 1 146 ? 132.022 143.091 126.205 1.00 47.23 ? 146 LEU A CB  1 
ATOM   869  C  CG  . LEU A 1 146 ? 132.820 142.597 127.398 1.00 47.23 ? 146 LEU A CG  1 
ATOM   870  C  CD1 . LEU A 1 146 ? 131.914 141.833 128.327 1.00 47.23 ? 146 LEU A CD1 1 
ATOM   871  C  CD2 . LEU A 1 146 ? 133.958 141.734 126.923 1.00 47.23 ? 146 LEU A CD2 1 
ATOM   872  N  N   . LEU A 1 147 ? 131.502 145.265 123.606 1.00 44.19 ? 147 LEU A N   1 
ATOM   873  C  CA  . LEU A 1 147 ? 130.859 145.434 122.312 1.00 44.19 ? 147 LEU A CA  1 
ATOM   874  C  C   . LEU A 1 147 ? 131.874 145.756 121.231 1.00 44.19 ? 147 LEU A C   1 
ATOM   875  O  O   . LEU A 1 147 ? 131.886 145.097 120.189 1.00 44.19 ? 147 LEU A O   1 
ATOM   876  C  CB  . LEU A 1 147 ? 129.781 146.518 122.389 1.00 44.19 ? 147 LEU A CB  1 
ATOM   877  C  CG  . LEU A 1 147 ? 128.804 146.654 121.220 1.00 44.19 ? 147 LEU A CG  1 
ATOM   878  C  CD1 . LEU A 1 147 ? 127.440 146.986 121.762 1.00 44.19 ? 147 LEU A CD1 1 
ATOM   879  C  CD2 . LEU A 1 147 ? 129.221 147.748 120.270 1.00 44.19 ? 147 LEU A CD2 1 
ATOM   880  N  N   . PHE A 1 148 ? 132.729 146.753 121.462 1.00 42.27 ? 148 PHE A N   1 
ATOM   881  C  CA  . PHE A 1 148 ? 133.810 147.030 120.529 1.00 42.27 ? 148 PHE A CA  1 
ATOM   882  C  C   . PHE A 1 148 ? 134.824 145.901 120.497 1.00 42.27 ? 148 PHE A C   1 
ATOM   883  O  O   . PHE A 1 148 ? 135.315 145.553 119.428 1.00 42.27 ? 148 PHE A O   1 
ATOM   884  C  CB  . PHE A 1 148 ? 134.474 148.359 120.866 1.00 42.27 ? 148 PHE A CB  1 
ATOM   885  C  CG  . PHE A 1 148 ? 133.682 149.540 120.418 1.00 42.27 ? 148 PHE A CG  1 
ATOM   886  C  CD1 . PHE A 1 148 ? 133.771 149.983 119.113 1.00 42.27 ? 148 PHE A CD1 1 
ATOM   887  C  CD2 . PHE A 1 148 ? 132.821 150.183 121.282 1.00 42.27 ? 148 PHE A CD2 1 
ATOM   888  C  CE1 . PHE A 1 148 ? 133.031 151.060 118.687 1.00 42.27 ? 148 PHE A CE1 1 
ATOM   889  C  CE2 . PHE A 1 148 ? 132.076 151.263 120.862 1.00 42.27 ? 148 PHE A CE2 1 
ATOM   890  C  CZ  . PHE A 1 148 ? 132.181 151.702 119.564 1.00 42.27 ? 148 PHE A CZ  1 
ATOM   891  N  N   . GLY A 1 149 ? 135.090 145.255 121.629 1.00 42.15 ? 149 GLY A N   1 
ATOM   892  C  CA  . GLY A 1 149 ? 135.934 144.073 121.615 1.00 42.15 ? 149 GLY A CA  1 
ATOM   893  C  C   . GLY A 1 149 ? 135.282 142.852 121.002 1.00 42.15 ? 149 GLY A C   1 
ATOM   894  O  O   . GLY A 1 149 ? 135.933 141.813 120.892 1.00 42.15 ? 149 GLY A O   1 
ATOM   895  N  N   . SER A 1 150 ? 133.998 142.937 120.643 1.00 44.01 ? 150 SER A N   1 
ATOM   896  C  CA  . SER A 1 150 ? 133.334 141.906 119.859 1.00 44.01 ? 150 SER A CA  1 
ATOM   897  C  C   . SER A 1 150 ? 133.315 142.217 118.378 1.00 44.01 ? 150 SER A C   1 
ATOM   898  O  O   . SER A 1 150 ? 133.279 141.290 117.569 1.00 44.01 ? 150 SER A O   1 
ATOM   899  C  CB  . SER A 1 150 ? 131.891 141.715 120.315 1.00 44.01 ? 150 SER A CB  1 
ATOM   900  O  OG  . SER A 1 150 ? 131.841 141.210 121.632 1.00 44.01 ? 150 SER A OG  1 
ATOM   901  N  N   . VAL A 1 151 ? 133.317 143.491 118.007 1.00 39.96 ? 151 VAL A N   1 
ATOM   902  C  CA  . VAL A 1 151 ? 133.382 143.873 116.603 1.00 39.96 ? 151 VAL A CA  1 
ATOM   903  C  C   . VAL A 1 151 ? 134.752 143.568 116.010 1.00 39.96 ? 151 VAL A C   1 
ATOM   904  O  O   . VAL A 1 151 ? 134.853 143.140 114.858 1.00 39.96 ? 151 VAL A O   1 
ATOM   905  C  CB  . VAL A 1 151 ? 133.001 145.354 116.474 1.00 39.96 ? 151 VAL A CB  1 
ATOM   906  C  CG1 . VAL A 1 151 ? 133.212 145.854 115.092 1.00 39.96 ? 151 VAL A CG1 1 
ATOM   907  C  CG2 . VAL A 1 151 ? 131.557 145.514 116.811 1.00 39.96 ? 151 VAL A CG2 1 
ATOM   908  N  N   . ILE A 1 152 ? 135.818 143.687 116.810 1.00 38.29 ? 152 ILE A N   1 
ATOM   909  C  CA  . ILE A 1 152 ? 137.164 143.397 116.321 1.00 38.29 ? 152 ILE A CA  1 
ATOM   910  C  C   . ILE A 1 152 ? 137.343 141.903 116.069 1.00 38.29 ? 152 ILE A C   1 
ATOM   911  O  O   . ILE A 1 152 ? 138.201 141.499 115.284 1.00 38.29 ? 152 ILE A O   1 
ATOM   912  C  CB  . ILE A 1 152 ? 138.225 143.938 117.290 1.00 38.29 ? 152 ILE A CB  1 
ATOM   913  C  CG1 . ILE A 1 152 ? 137.936 145.377 117.631 1.00 38.29 ? 152 ILE A CG1 1 
ATOM   914  C  CG2 . ILE A 1 152 ? 139.509 144.086 116.582 1.00 38.29 ? 152 ILE A CG2 1 
ATOM   915  C  CD1 . ILE A 1 152 ? 138.725 145.880 118.789 1.00 38.29 ? 152 ILE A CD1 1 
ATOM   916  N  N   . GLN A 1 153 ? 136.521 141.056 116.673 1.00 41.22 ? 153 GLN A N   1 
ATOM   917  C  CA  . GLN A 1 153 ? 136.532 139.650 116.309 1.00 41.22 ? 153 GLN A CA  1 
ATOM   918  C  C   . GLN A 1 153 ? 135.685 139.368 115.076 1.00 41.22 ? 153 GLN A C   1 
ATOM   919  O  O   . GLN A 1 153 ? 135.668 138.232 114.605 1.00 41.22 ? 153 GLN A O   1 
ATOM   920  C  CB  . GLN A 1 153 ? 136.052 138.780 117.471 1.00 41.22 ? 153 GLN A CB  1 
ATOM   921  C  CG  . GLN A 1 153 ? 136.801 138.969 118.776 1.00 41.22 ? 153 GLN A CG  1 
ATOM   922  C  CD  . GLN A 1 153 ? 138.249 138.571 118.712 1.00 41.22 ? 153 GLN A CD  1 
ATOM   923  O  OE1 . GLN A 1 153 ? 138.603 137.575 118.093 1.00 41.22 ? 153 GLN A OE1 1 
ATOM   924  N  NE2 . GLN A 1 153 ? 139.102 139.352 119.363 1.00 41.22 ? 153 GLN A NE2 1 
ATOM   925  N  N   . LEU A 1 154 ? 134.970 140.361 114.549 1.00 40.96 ? 154 LEU A N   1 
ATOM   926  C  CA  . LEU A 1 154 ? 134.213 140.200 113.311 1.00 40.96 ? 154 LEU A CA  1 
ATOM   927  C  C   . LEU A 1 154 ? 134.945 140.770 112.108 1.00 40.96 ? 154 LEU A C   1 
ATOM   928  O  O   . LEU A 1 154 ? 134.824 140.240 111.002 1.00 40.96 ? 154 LEU A O   1 
ATOM   929  C  CB  . LEU A 1 154 ? 132.834 140.854 113.437 1.00 40.96 ? 154 LEU A CB  1 
ATOM   930  C  CG  . LEU A 1 154 ? 131.886 140.752 112.249 1.00 40.96 ? 154 LEU A CG  1 
ATOM   931  C  CD1 . LEU A 1 154 ? 131.654 139.316 111.956 1.00 40.96 ? 154 LEU A CD1 1 
ATOM   932  C  CD2 . LEU A 1 154 ? 130.585 141.416 112.545 1.00 40.96 ? 154 LEU A CD2 1 
ATOM   933  N  N   . ILE A 1 155 ? 135.713 141.837 112.309 1.00 41.56 ? 155 ILE A N   1 
ATOM   934  C  CA  . ILE A 1 155 ? 136.639 142.307 111.286 1.00 41.56 ? 155 ILE A CA  1 
ATOM   935  C  C   . ILE A 1 155 ? 137.724 141.270 111.037 1.00 41.56 ? 155 ILE A C   1 
ATOM   936  O  O   . ILE A 1 155 ? 138.083 140.985 109.890 1.00 41.56 ? 155 ILE A O   1 
ATOM   937  C  CB  . ILE A 1 155 ? 137.245 143.647 111.728 1.00 41.56 ? 155 ILE A CB  1 
ATOM   938  C  CG1 . ILE A 1 155 ? 136.152 144.682 111.896 1.00 41.56 ? 155 ILE A CG1 1 
ATOM   939  C  CG2 . ILE A 1 155 ? 138.262 144.123 110.744 1.00 41.56 ? 155 ILE A CG2 1 
ATOM   940  C  CD1 . ILE A 1 155 ? 136.623 145.914 112.547 1.00 41.56 ? 155 ILE A CD1 1 
ATOM   941  N  N   . ALA A 1 156 ? 138.238 140.665 112.112 1.00 41.43 ? 156 ALA A N   1 
ATOM   942  C  CA  . ALA A 1 156 ? 139.381 139.767 112.019 1.00 41.43 ? 156 ALA A CA  1 
ATOM   943  C  C   . ALA A 1 156 ? 139.036 138.447 111.354 1.00 41.43 ? 156 ALA A C   1 
ATOM   944  O  O   . ALA A 1 156 ? 139.935 137.753 110.881 1.00 41.43 ? 156 ALA A O   1 
ATOM   945  C  CB  . ALA A 1 156 ? 139.949 139.506 113.404 1.00 41.43 ? 156 ALA A CB  1 
ATOM   946  N  N   . CYS A 1 157 ? 137.767 138.055 111.337 1.00 42.87 ? 157 CYS A N   1 
ATOM   947  C  CA  . CYS A 1 157 ? 137.422 136.824 110.644 1.00 42.87 ? 157 CYS A CA  1 
ATOM   948  C  C   . CYS A 1 157 ? 137.351 137.012 109.140 1.00 42.87 ? 157 CYS A C   1 
ATOM   949  O  O   . CYS A 1 157 ? 137.372 136.020 108.409 1.00 42.87 ? 157 CYS A O   1 
ATOM   950  C  CB  . CYS A 1 157 ? 136.104 136.267 111.161 1.00 42.87 ? 157 CYS A CB  1 
ATOM   951  S  SG  . CYS A 1 157 ? 136.190 135.603 112.825 1.00 42.87 ? 157 CYS A SG  1 
ATOM   952  N  N   . ALA A 1 158 ? 137.265 138.248 108.654 1.00 47.05 ? 158 ALA A N   1 
ATOM   953  C  CA  . ALA A 1 158 ? 137.270 138.460 107.213 1.00 47.05 ? 158 ALA A CA  1 
ATOM   954  C  C   . ALA A 1 158 ? 138.685 138.656 106.692 1.00 47.05 ? 158 ALA A C   1 
ATOM   955  O  O   . ALA A 1 158 ? 139.021 138.177 105.608 1.00 47.05 ? 158 ALA A O   1 
ATOM   956  C  CB  . ALA A 1 158 ? 136.394 139.653 106.845 1.00 47.05 ? 158 ALA A CB  1 
ATOM   957  N  N   . SER A 1 159 ? 139.532 139.343 107.451 1.00 46.28 ? 159 SER A N   1 
ATOM   958  C  CA  . SER A 1 159 ? 140.900 139.578 107.015 1.00 46.28 ? 159 SER A CA  1 
ATOM   959  C  C   . SER A 1 159 ? 141.752 138.327 107.052 1.00 46.28 ? 159 SER A C   1 
ATOM   960  O  O   . SER A 1 159 ? 142.806 138.306 106.418 1.00 46.28 ? 159 SER A O   1 
ATOM   961  C  CB  . SER A 1 159 ? 141.558 140.666 107.863 1.00 46.28 ? 159 SER A CB  1 
ATOM   962  O  OG  . SER A 1 159 ? 140.958 141.924 107.634 1.00 46.28 ? 159 SER A OG  1 
ATOM   963  N  N   . ASN A 1 160 ? 141.336 137.294 107.776 1.00 46.58 ? 160 ASN A N   1 
ATOM   964  C  CA  . ASN A 1 160 ? 141.961 135.984 107.671 1.00 46.58 ? 160 ASN A CA  1 
ATOM   965  C  C   . ASN A 1 160 ? 141.388 135.136 106.553 1.00 46.58 ? 160 ASN A C   1 
ATOM   966  O  O   . ASN A 1 160 ? 142.135 134.424 105.894 1.00 46.58 ? 160 ASN A O   1 
ATOM   967  C  CB  . ASN A 1 160 ? 141.843 135.207 108.983 1.00 46.58 ? 160 ASN A CB  1 
ATOM   968  C  CG  . ASN A 1 160 ? 142.824 135.652 110.019 1.00 46.58 ? 160 ASN A CG  1 
ATOM   969  O  OD1 . ASN A 1 160 ? 142.452 136.202 111.046 1.00 46.58 ? 160 ASN A OD1 1 
ATOM   970  N  ND2 . ASN A 1 160 ? 144.089 135.388 109.775 1.00 46.58 ? 160 ASN A ND2 1 
ATOM   971  N  N   . ILE A 1 161 ? 140.081 135.194 106.298 1.00 49.72 ? 161 ILE A N   1 
ATOM   972  C  CA  . ILE A 1 161 ? 139.499 134.328 105.282 1.00 49.72 ? 161 ILE A CA  1 
ATOM   973  C  C   . ILE A 1 161 ? 139.806 134.810 103.871 1.00 49.72 ? 161 ILE A C   1 
ATOM   974  O  O   . ILE A 1 161 ? 139.643 134.054 102.911 1.00 49.72 ? 161 ILE A O   1 
ATOM   975  C  CB  . ILE A 1 161 ? 137.982 134.219 105.522 1.00 49.72 ? 161 ILE A CB  1 
ATOM   976  C  CG1 . ILE A 1 161 ? 137.380 132.966 104.889 1.00 49.72 ? 161 ILE A CG1 1 
ATOM   977  C  CG2 . ILE A 1 161 ? 137.277 135.426 104.992 1.00 49.72 ? 161 ILE A CG2 1 
ATOM   978  C  CD1 . ILE A 1 161 ? 137.717 131.709 105.616 1.00 49.72 ? 161 ILE A CD1 1 
ATOM   979  N  N   . TYR A 1 162 ? 140.286 136.045 103.718 1.00 53.07 ? 162 TYR A N   1 
ATOM   980  C  CA  . TYR A 1 162 ? 140.672 136.555 102.408 1.00 53.07 ? 162 TYR A CA  1 
ATOM   981  C  C   . TYR A 1 162 ? 142.000 135.976 101.947 1.00 53.07 ? 162 TYR A C   1 
ATOM   982  O  O   . TYR A 1 162 ? 142.337 136.086 100.769 1.00 53.07 ? 162 TYR A O   1 
ATOM   983  C  CB  . TYR A 1 162 ? 140.719 138.080 102.472 1.00 53.07 ? 162 TYR A CB  1 
ATOM   984  C  CG  . TYR A 1 162 ? 141.087 138.807 101.207 1.00 53.07 ? 162 TYR A CG  1 
ATOM   985  C  CD1 . TYR A 1 162 ? 140.189 138.947 100.166 1.00 53.07 ? 162 TYR A CD1 1 
ATOM   986  C  CD2 . TYR A 1 162 ? 142.334 139.385 101.070 1.00 53.07 ? 162 TYR A CD2 1 
ATOM   987  C  CE1 . TYR A 1 162 ? 140.537 139.636 99.015  1.00 53.07 ? 162 TYR A CE1 1 
ATOM   988  C  CE2 . TYR A 1 162 ? 142.690 140.069 99.929  1.00 53.07 ? 162 TYR A CE2 1 
ATOM   989  C  CZ  . TYR A 1 162 ? 141.787 140.189 98.908  1.00 53.07 ? 162 TYR A CZ  1 
ATOM   990  O  OH  . TYR A 1 162 ? 142.134 140.866 97.772  1.00 53.07 ? 162 TYR A OH  1 
ATOM   991  N  N   . TYR A 1 163 ? 142.743 135.332 102.838 1.00 50.65 ? 163 TYR A N   1 
ATOM   992  C  CA  . TYR A 1 163 ? 144.049 134.772 102.530 1.00 50.65 ? 163 TYR A CA  1 
ATOM   993  C  C   . TYR A 1 163 ? 144.013 133.265 102.343 1.00 50.65 ? 163 TYR A C   1 
ATOM   994  O  O   . TYR A 1 163 ? 145.061 132.650 102.146 1.00 50.65 ? 163 TYR A O   1 
ATOM   995  C  CB  . TYR A 1 163 ? 145.016 135.175 103.633 1.00 50.65 ? 163 TYR A CB  1 
ATOM   996  C  CG  . TYR A 1 163 ? 145.273 136.656 103.599 1.00 50.65 ? 163 TYR A CG  1 
ATOM   997  C  CD1 . TYR A 1 163 ? 145.252 137.350 102.402 1.00 50.65 ? 163 TYR A CD1 1 
ATOM   998  C  CD2 . TYR A 1 163 ? 145.432 137.376 104.758 1.00 50.65 ? 163 TYR A CD2 1 
ATOM   999  C  CE1 . TYR A 1 163 ? 145.469 138.702 102.358 1.00 50.65 ? 163 TYR A CE1 1 
ATOM   1000 C  CE2 . TYR A 1 163 ? 145.639 138.735 104.723 1.00 50.65 ? 163 TYR A CE2 1 
ATOM   1001 C  CZ  . TYR A 1 163 ? 145.645 139.389 103.518 1.00 50.65 ? 163 TYR A CZ  1 
ATOM   1002 O  OH  . TYR A 1 163 ? 145.851 140.742 103.465 1.00 50.65 ? 163 TYR A OH  1 
ATOM   1003 N  N   . ILE A 1 164 ? 142.832 132.670 102.425 1.00 53.38 ? 164 ILE A N   1 
ATOM   1004 C  CA  . ILE A 1 164 ? 142.588 131.319 101.947 1.00 53.38 ? 164 ILE A CA  1 
ATOM   1005 C  C   . ILE A 1 164 ? 141.687 131.318 100.718 1.00 53.38 ? 164 ILE A C   1 
ATOM   1006 O  O   . ILE A 1 164 ? 141.883 130.479 99.825  1.00 53.38 ? 164 ILE A O   1 
ATOM   1007 C  CB  . ILE A 1 164 ? 142.003 130.438 103.078 1.00 53.38 ? 164 ILE A CB  1 
ATOM   1008 C  CG1 . ILE A 1 164 ? 141.630 129.026 102.630 1.00 53.38 ? 164 ILE A CG1 1 
ATOM   1009 C  CG2 . ILE A 1 164 ? 140.818 131.081 103.722 1.00 53.38 ? 164 ILE A CG2 1 
ATOM   1010 C  CD1 . ILE A 1 164 ? 142.762 128.200 102.178 1.00 53.38 ? 164 ILE A CD1 1 
ATOM   1011 N  N   . ASN A 1 165 ? 140.789 132.291 100.588 1.00 58.67 ? 165 ASN A N   1 
ATOM   1012 C  CA  . ASN A 1 165 ? 139.857 132.348 99.467  1.00 58.67 ? 165 ASN A CA  1 
ATOM   1013 C  C   . ASN A 1 165 ? 139.584 133.815 99.166  1.00 58.67 ? 165 ASN A C   1 
ATOM   1014 O  O   . ASN A 1 165 ? 138.733 134.418 99.820  1.00 58.67 ? 165 ASN A O   1 
ATOM   1015 C  CB  . ASN A 1 165 ? 138.576 131.621 99.820  1.00 58.67 ? 165 ASN A CB  1 
ATOM   1016 C  CG  . ASN A 1 165 ? 137.670 131.433 98.640  1.00 58.67 ? 165 ASN A CG  1 
ATOM   1017 O  OD1 . ASN A 1 165 ? 138.001 131.809 97.518  1.00 58.67 ? 165 ASN A OD1 1 
ATOM   1018 N  ND2 . ASN A 1 165 ? 136.504 130.848 98.883  1.00 58.67 ? 165 ASN A ND2 1 
ATOM   1019 N  N   . ASP A 1 166 ? 140.270 134.376 98.172  1.00 61.37 ? 166 ASP A N   1 
ATOM   1020 C  CA  . ASP A 1 166 ? 140.122 135.783 97.821  1.00 61.37 ? 166 ASP A CA  1 
ATOM   1021 C  C   . ASP A 1 166 ? 139.287 135.998 96.570  1.00 61.37 ? 166 ASP A C   1 
ATOM   1022 O  O   . ASP A 1 166 ? 139.504 136.979 95.854  1.00 61.37 ? 166 ASP A O   1 
ATOM   1023 C  CB  . ASP A 1 166 ? 141.489 136.445 97.660  1.00 61.37 ? 166 ASP A CB  1 
ATOM   1024 C  CG  . ASP A 1 166 ? 142.389 135.721 96.675  1.00 61.37 ? 166 ASP A CG  1 
ATOM   1025 O  OD1 . ASP A 1 166 ? 141.999 134.660 96.142  1.00 61.37 ? 166 ASP A OD1 1 
ATOM   1026 O  OD2 . ASP A 1 166 ? 143.516 136.209 96.447  1.00 61.37 ? 166 ASP A OD2 1 
ATOM   1027 N  N   . HIS A 1 167 ? 138.364 135.086 96.274  1.00 63.34 ? 167 HIS A N   1 
ATOM   1028 C  CA  . HIS A 1 167 ? 137.428 135.299 95.181  1.00 63.34 ? 167 HIS A CA  1 
ATOM   1029 C  C   . HIS A 1 167 ? 136.375 136.348 95.498  1.00 63.34 ? 167 HIS A C   1 
ATOM   1030 O  O   . HIS A 1 167 ? 135.897 137.009 94.574  1.00 63.34 ? 167 HIS A O   1 
ATOM   1031 C  CB  . HIS A 1 167 ? 136.746 133.985 94.793  1.00 63.34 ? 167 HIS A CB  1 
ATOM   1032 C  CG  . HIS A 1 167 ? 137.619 133.060 94.004  1.00 63.34 ? 167 HIS A CG  1 
ATOM   1033 N  ND1 . HIS A 1 167 ? 138.511 132.189 94.591  1.00 63.34 ? 167 HIS A ND1 1 
ATOM   1034 C  CD2 . HIS A 1 167 ? 137.722 132.858 92.669  1.00 63.34 ? 167 HIS A CD2 1 
ATOM   1035 C  CE1 . HIS A 1 167 ? 139.135 131.500 93.653  1.00 63.34 ? 167 HIS A CE1 1 
ATOM   1036 N  NE2 . HIS A 1 167 ? 138.674 131.886 92.478  1.00 63.34 ? 167 HIS A NE2 1 
ATOM   1037 N  N   . LEU A 1 168 ? 136.009 136.524 96.763  1.00 56.23 ? 168 LEU A N   1 
ATOM   1038 C  CA  . LEU A 1 168 ? 135.185 137.647 97.172  1.00 56.23 ? 168 LEU A CA  1 
ATOM   1039 C  C   . LEU A 1 168 ? 136.077 138.743 97.731  1.00 56.23 ? 168 LEU A C   1 
ATOM   1040 O  O   . LEU A 1 168 ? 137.273 138.558 97.937  1.00 56.23 ? 168 LEU A O   1 
ATOM   1041 C  CB  . LEU A 1 168 ? 134.149 137.232 98.207  1.00 56.23 ? 168 LEU A CB  1 
ATOM   1042 C  CG  . LEU A 1 168 ? 133.105 136.222 97.762  1.00 56.23 ? 168 LEU A CG  1 
ATOM   1043 C  CD1 . LEU A 1 168 ? 132.131 135.952 98.890  1.00 56.23 ? 168 LEU A CD1 1 
ATOM   1044 C  CD2 . LEU A 1 168 ? 132.389 136.703 96.531  1.00 56.23 ? 168 LEU A CD2 1 
ATOM   1045 N  N   . ASP A 1 169 ? 135.479 139.889 98.022  1.00 55.03 ? 169 ASP A N   1 
ATOM   1046 C  CA  . ASP A 1 169 ? 136.233 141.059 98.442  1.00 55.03 ? 169 ASP A CA  1 
ATOM   1047 C  C   . ASP A 1 169 ? 136.647 140.910 99.901  1.00 55.03 ? 169 ASP A C   1 
ATOM   1048 O  O   . ASP A 1 169 ? 136.478 139.857 100.515 1.00 55.03 ? 169 ASP A O   1 
ATOM   1049 C  CB  . ASP A 1 169 ? 135.402 142.318 98.242  1.00 55.03 ? 169 ASP A CB  1 
ATOM   1050 C  CG  . ASP A 1 169 ? 135.008 142.526 96.809  1.00 55.03 ? 169 ASP A CG  1 
ATOM   1051 O  OD1 . ASP A 1 169 ? 135.742 142.062 95.914  1.00 55.03 ? 169 ASP A OD1 1 
ATOM   1052 O  OD2 . ASP A 1 169 ? 133.953 143.149 96.579  1.00 55.03 ? 169 ASP A OD2 1 
ATOM   1053 N  N   . LYS A 1 170 ? 137.195 141.970 100.479 1.00 53.61 ? 170 LYS A N   1 
ATOM   1054 C  CA  . LYS A 1 170 ? 137.502 141.940 101.900 1.00 53.61 ? 170 LYS A CA  1 
ATOM   1055 C  C   . LYS A 1 170 ? 136.264 142.101 102.761 1.00 53.61 ? 170 LYS A C   1 
ATOM   1056 O  O   . LYS A 1 170 ? 136.135 141.415 103.775 1.00 53.61 ? 170 LYS A O   1 
ATOM   1057 C  CB  . LYS A 1 170 ? 138.506 143.035 102.256 1.00 53.61 ? 170 LYS A CB  1 
ATOM   1058 C  CG  . LYS A 1 170 ? 138.940 143.016 103.699 1.00 53.61 ? 170 LYS A CG  1 
ATOM   1059 C  CD  . LYS A 1 170 ? 139.758 141.788 104.009 1.00 53.61 ? 170 LYS A CD  1 
ATOM   1060 C  CE  . LYS A 1 170 ? 141.163 141.898 103.459 1.00 53.61 ? 170 LYS A CE  1 
ATOM   1061 N  NZ  . LYS A 1 170 ? 141.943 142.888 104.239 1.00 53.61 ? 170 LYS A NZ  1 
ATOM   1062 N  N   . ARG A 1 171 ? 135.344 142.985 102.391 1.00 52.60 ? 171 ARG A N   1 
ATOM   1063 C  CA  . ARG A 1 171 ? 134.171 143.192 103.221 1.00 52.60 ? 171 ARG A CA  1 
ATOM   1064 C  C   . ARG A 1 171 ? 132.974 142.393 102.758 1.00 52.60 ? 171 ARG A C   1 
ATOM   1065 O  O   . ARG A 1 171 ? 131.951 142.404 103.444 1.00 52.60 ? 171 ARG A O   1 
ATOM   1066 C  CB  . ARG A 1 171 ? 133.756 144.662 103.258 1.00 52.60 ? 171 ARG A CB  1 
ATOM   1067 C  CG  . ARG A 1 171 ? 133.074 145.135 101.985 1.00 52.60 ? 171 ARG A CG  1 
ATOM   1068 C  CD  . ARG A 1 171 ? 132.516 146.544 102.131 1.00 52.60 ? 171 ARG A CD  1 
ATOM   1069 N  NE  . ARG A 1 171 ? 131.931 147.028 100.887 1.00 52.60 ? 171 ARG A NE  1 
ATOM   1070 C  CZ  . ARG A 1 171 ? 130.676 146.808 100.518 1.00 52.60 ? 171 ARG A CZ  1 
ATOM   1071 N  NH1 . ARG A 1 171 ? 129.867 146.116 101.299 1.00 52.60 ? 171 ARG A NH1 1 
ATOM   1072 N  NH2 . ARG A 1 171 ? 130.230 147.286 99.369  1.00 52.60 ? 171 ARG A NH2 1 
ATOM   1073 N  N   . THR A 1 172 ? 133.052 141.727 101.612 1.00 52.25 ? 172 THR A N   1 
ATOM   1074 C  CA  . THR A 1 172 ? 131.930 140.894 101.204 1.00 52.25 ? 172 THR A CA  1 
ATOM   1075 C  C   . THR A 1 172 ? 131.821 139.661 102.093 1.00 52.25 ? 172 THR A C   1 
ATOM   1076 O  O   . THR A 1 172 ? 130.717 139.154 102.317 1.00 52.25 ? 172 THR A O   1 
ATOM   1077 C  CB  . THR A 1 172 ? 132.068 140.538 99.726  1.00 52.25 ? 172 THR A CB  1 
ATOM   1078 O  OG1 . THR A 1 172 ? 132.175 141.749 98.972  1.00 52.25 ? 172 THR A OG1 1 
ATOM   1079 C  CG2 . THR A 1 172 ? 130.858 139.778 99.209  1.00 52.25 ? 172 THR A CG2 1 
ATOM   1080 N  N   . TRP A 1 173 ? 132.935 139.215 102.679 1.00 53.18 ? 173 TRP A N   1 
ATOM   1081 C  CA  . TRP A 1 173 ? 132.874 138.147 103.669 1.00 53.18 ? 173 TRP A CA  1 
ATOM   1082 C  C   . TRP A 1 173 ? 132.209 138.579 104.965 1.00 53.18 ? 173 TRP A C   1 
ATOM   1083 O  O   . TRP A 1 173 ? 131.713 137.721 105.697 1.00 53.18 ? 173 TRP A O   1 
ATOM   1084 C  CB  . TRP A 1 173 ? 134.262 137.617 103.998 1.00 53.18 ? 173 TRP A CB  1 
ATOM   1085 C  CG  . TRP A 1 173 ? 134.875 136.860 102.908 1.00 53.18 ? 173 TRP A CG  1 
ATOM   1086 C  CD1 . TRP A 1 173 ? 135.890 137.258 102.115 1.00 53.18 ? 173 TRP A CD1 1 
ATOM   1087 C  CD2 . TRP A 1 173 ? 134.493 135.566 102.460 1.00 53.18 ? 173 TRP A CD2 1 
ATOM   1088 N  NE1 . TRP A 1 173 ? 136.186 136.285 101.206 1.00 53.18 ? 173 TRP A NE1 1 
ATOM   1089 C  CE2 . TRP A 1 173 ? 135.335 135.233 101.397 1.00 53.18 ? 173 TRP A CE2 1 
ATOM   1090 C  CE3 . TRP A 1 173 ? 133.525 134.653 102.864 1.00 53.18 ? 173 TRP A CE3 1 
ATOM   1091 C  CZ2 . TRP A 1 173 ? 135.242 134.027 100.732 1.00 53.18 ? 173 TRP A CZ2 1 
ATOM   1092 C  CZ3 . TRP A 1 173 ? 133.432 133.460 102.205 1.00 53.18 ? 173 TRP A CZ3 1 
ATOM   1093 C  CH2 . TRP A 1 173 ? 134.282 133.155 101.147 1.00 53.18 ? 173 TRP A CH2 1 
ATOM   1094 N  N   . THR A 1 174 ? 132.193 139.875 105.273 1.00 50.34 ? 174 THR A N   1 
ATOM   1095 C  CA  . THR A 1 174 ? 131.517 140.348 106.471 1.00 50.34 ? 174 THR A CA  1 
ATOM   1096 C  C   . THR A 1 174 ? 130.008 140.145 106.374 1.00 50.34 ? 174 THR A C   1 
ATOM   1097 O  O   . THR A 1 174 ? 129.357 139.964 107.400 1.00 50.34 ? 174 THR A O   1 
ATOM   1098 C  CB  . THR A 1 174 ? 131.886 141.815 106.705 1.00 50.34 ? 174 THR A CB  1 
ATOM   1099 O  OG1 . THR A 1 174 ? 133.306 141.944 106.660 1.00 50.34 ? 174 THR A OG1 1 
ATOM   1100 C  CG2 . THR A 1 174 ? 131.452 142.301 108.064 1.00 50.34 ? 174 THR A CG2 1 
ATOM   1101 N  N   . TYR A 1 175 ? 129.444 140.109 105.163 1.00 52.45 ? 175 TYR A N   1 
ATOM   1102 C  CA  . TYR A 1 175 ? 128.032 139.761 105.010 1.00 52.45 ? 175 TYR A CA  1 
ATOM   1103 C  C   . TYR A 1 175 ? 127.760 138.321 105.406 1.00 52.45 ? 175 TYR A C   1 
ATOM   1104 O  O   . TYR A 1 175 ? 126.673 138.012 105.898 1.00 52.45 ? 175 TYR A O   1 
ATOM   1105 C  CB  . TYR A 1 175 ? 127.569 139.945 103.567 1.00 52.45 ? 175 TYR A CB  1 
ATOM   1106 C  CG  . TYR A 1 175 ? 127.572 141.352 103.059 1.00 52.45 ? 175 TYR A CG  1 
ATOM   1107 C  CD1 . TYR A 1 175 ? 126.542 142.220 103.359 1.00 52.45 ? 175 TYR A CD1 1 
ATOM   1108 C  CD2 . TYR A 1 175 ? 128.595 141.802 102.255 1.00 52.45 ? 175 TYR A CD2 1 
ATOM   1109 C  CE1 . TYR A 1 175 ? 126.546 143.511 102.881 1.00 52.45 ? 175 TYR A CE1 1 
ATOM   1110 C  CE2 . TYR A 1 175 ? 128.611 143.083 101.778 1.00 52.45 ? 175 TYR A CE2 1 
ATOM   1111 C  CZ  . TYR A 1 175 ? 127.589 143.932 102.091 1.00 52.45 ? 175 TYR A CZ  1 
ATOM   1112 O  OH  . TYR A 1 175 ? 127.618 145.212 101.597 1.00 52.45 ? 175 TYR A OH  1 
ATOM   1113 N  N   . ILE A 1 176 ? 128.715 137.431 105.170 1.00 51.43 ? 176 ILE A N   1 
ATOM   1114 C  CA  . ILE A 1 176 ? 128.501 136.009 105.376 1.00 51.43 ? 176 ILE A CA  1 
ATOM   1115 C  C   . ILE A 1 176 ? 128.918 135.589 106.775 1.00 51.43 ? 176 ILE A C   1 
ATOM   1116 O  O   . ILE A 1 176 ? 128.243 134.794 107.427 1.00 51.43 ? 176 ILE A O   1 
ATOM   1117 C  CB  . ILE A 1 176 ? 129.254 135.219 104.293 1.00 51.43 ? 176 ILE A CB  1 
ATOM   1118 C  CG1 . ILE A 1 176 ? 128.821 135.700 102.917 1.00 51.43 ? 176 ILE A CG1 1 
ATOM   1119 C  CG2 . ILE A 1 176 ? 128.937 133.749 104.395 1.00 51.43 ? 176 ILE A CG2 1 
ATOM   1120 C  CD1 . ILE A 1 176 ? 129.703 135.211 101.805 1.00 51.43 ? 176 ILE A CD1 1 
ATOM   1121 N  N   . PHE A 1 177 ? 130.024 136.131 107.267 1.00 52.08 ? 177 PHE A N   1 
ATOM   1122 C  CA  . PHE A 1 177 ? 130.460 135.874 108.633 1.00 52.08 ? 177 PHE A CA  1 
ATOM   1123 C  C   . PHE A 1 177 ? 129.802 136.801 109.639 1.00 52.08 ? 177 PHE A C   1 
ATOM   1124 O  O   . PHE A 1 177 ? 130.057 136.663 110.838 1.00 52.08 ? 177 PHE A O   1 
ATOM   1125 C  CB  . PHE A 1 177 ? 131.976 136.012 108.749 1.00 52.08 ? 177 PHE A CB  1 
ATOM   1126 C  CG  . PHE A 1 177 ? 132.740 134.929 108.056 1.00 52.08 ? 177 PHE A CG  1 
ATOM   1127 C  CD1 . PHE A 1 177 ? 132.122 133.762 107.647 1.00 52.08 ? 177 PHE A CD1 1 
ATOM   1128 C  CD2 . PHE A 1 177 ? 134.087 135.070 107.835 1.00 52.08 ? 177 PHE A CD2 1 
ATOM   1129 C  CE1 . PHE A 1 177 ? 132.837 132.770 107.009 1.00 52.08 ? 177 PHE A CE1 1 
ATOM   1130 C  CE2 . PHE A 1 177 ? 134.800 134.079 107.210 1.00 52.08 ? 177 PHE A CE2 1 
ATOM   1131 C  CZ  . PHE A 1 177 ? 134.178 132.932 106.794 1.00 52.08 ? 177 PHE A CZ  1 
ATOM   1132 N  N   . GLY A 1 178 ? 128.985 137.743 109.184 1.00 53.87 ? 178 GLY A N   1 
ATOM   1133 C  CA  . GLY A 1 178 ? 128.256 138.609 110.080 1.00 53.87 ? 178 GLY A CA  1 
ATOM   1134 C  C   . GLY A 1 178 ? 126.820 138.174 110.200 1.00 53.87 ? 178 GLY A C   1 
ATOM   1135 O  O   . GLY A 1 178 ? 126.178 138.425 111.218 1.00 53.87 ? 178 GLY A O   1 
ATOM   1136 N  N   . ALA A 1 179 ? 126.307 137.509 109.175 1.00 57.88 ? 179 ALA A N   1 
ATOM   1137 C  CA  . ALA A 1 179 ? 125.003 136.881 109.297 1.00 57.88 ? 179 ALA A CA  1 
ATOM   1138 C  C   . ALA A 1 179 ? 125.080 135.540 110.005 1.00 57.88 ? 179 ALA A C   1 
ATOM   1139 O  O   . ALA A 1 179 ? 124.055 135.043 110.479 1.00 57.88 ? 179 ALA A O   1 
ATOM   1140 C  CB  . ALA A 1 179 ? 124.359 136.699 107.923 1.00 57.88 ? 179 ALA A CB  1 
ATOM   1141 N  N   . CYS A 1 180 ? 126.263 134.931 110.079 1.00 59.59 ? 180 CYS A N   1 
ATOM   1142 C  CA  . CYS A 1 180 ? 126.438 133.735 110.889 1.00 59.59 ? 180 CYS A CA  1 
ATOM   1143 C  C   . CYS A 1 180 ? 126.636 134.043 112.362 1.00 59.59 ? 180 CYS A C   1 
ATOM   1144 O  O   . CYS A 1 180 ? 126.174 133.270 113.203 1.00 59.59 ? 180 CYS A O   1 
ATOM   1145 C  CB  . CYS A 1 180 ? 127.622 132.911 110.388 1.00 59.59 ? 180 CYS A CB  1 
ATOM   1146 S  SG  . CYS A 1 180 ? 127.337 132.050 108.835 1.00 59.59 ? 180 CYS A SG  1 
ATOM   1147 N  N   . CYS A 1 181 ? 127.294 135.145 112.702 1.00 62.16 ? 181 CYS A N   1 
ATOM   1148 C  CA  . CYS A 1 181 ? 127.441 135.536 114.094 1.00 62.16 ? 181 CYS A CA  1 
ATOM   1149 C  C   . CYS A 1 181 ? 126.132 135.988 114.722 1.00 62.16 ? 181 CYS A C   1 
ATOM   1150 O  O   . CYS A 1 181 ? 125.930 135.782 115.923 1.00 62.16 ? 181 CYS A O   1 
ATOM   1151 C  CB  . CYS A 1 181 ? 128.697 136.378 114.280 1.00 62.16 ? 181 CYS A CB  1 
ATOM   1152 S  SG  . CYS A 1 181 ? 128.546 138.038 113.636 1.00 62.16 ? 181 CYS A SG  1 
ATOM   1153 N  N   . ALA A 1 182 ? 125.260 136.635 113.955 1.00 63.53 ? 182 ALA A N   1 
ATOM   1154 C  CA  . ALA A 1 182 ? 123.856 136.764 114.304 1.00 63.53 ? 182 ALA A CA  1 
ATOM   1155 C  C   . ALA A 1 182 ? 123.051 135.529 114.660 1.00 63.53 ? 182 ALA A C   1 
ATOM   1156 O  O   . ALA A 1 182 ? 122.122 135.627 115.463 1.00 63.53 ? 182 ALA A O   1 
ATOM   1157 C  CB  . ALA A 1 182 ? 123.168 137.763 113.369 1.00 63.53 ? 182 ALA A CB  1 
ATOM   1158 N  N   . THR A 1 183 ? 123.352 134.382 114.052 1.00 63.86 ? 183 THR A N   1 
ATOM   1159 C  CA  . THR A 1 183 ? 122.765 133.128 114.492 1.00 63.86 ? 183 THR A CA  1 
ATOM   1160 C  C   . THR A 1 183 ? 122.977 132.672 115.923 1.00 63.86 ? 183 THR A C   1 
ATOM   1161 O  O   . THR A 1 183 ? 122.179 131.878 116.426 1.00 63.86 ? 183 THR A O   1 
ATOM   1162 C  CB  . THR A 1 183 ? 123.005 132.047 113.444 1.00 63.86 ? 183 THR A CB  1 
ATOM   1163 O  OG1 . THR A 1 183 ? 124.397 131.719 113.404 1.00 63.86 ? 183 THR A OG1 1 
ATOM   1164 C  CG2 . THR A 1 183 ? 122.546 132.528 112.081 1.00 63.86 ? 183 THR A CG2 1 
ATOM   1165 N  N   . THR A 1 184 ? 124.035 133.138 116.581 1.00 64.59 ? 184 THR A N   1 
ATOM   1166 C  CA  . THR A 1 184 ? 124.103 133.052 118.031 1.00 64.59 ? 184 THR A CA  1 
ATOM   1167 C  C   . THR A 1 184 ? 122.929 133.632 118.800 1.00 64.59 ? 184 THR A C   1 
ATOM   1168 O  O   . THR A 1 184 ? 122.755 133.309 119.977 1.00 64.59 ? 184 THR A O   1 
ATOM   1169 C  CB  . THR A 1 184 ? 125.456 133.532 118.556 1.00 64.59 ? 184 THR A CB  1 
ATOM   1170 O  OG1 . THR A 1 184 ? 125.607 133.127 119.918 1.00 64.59 ? 184 THR A OG1 1 
ATOM   1171 C  CG2 . THR A 1 184 ? 125.545 135.024 118.485 1.00 64.59 ? 184 THR A CG2 1 
ATOM   1172 N  N   . VAL A 1 185 ? 122.139 134.500 118.165 1.00 64.91 ? 185 VAL A N   1 
ATOM   1173 C  CA  . VAL A 1 185 ? 120.893 134.970 118.756 1.00 64.91 ? 185 VAL A CA  1 
ATOM   1174 C  C   . VAL A 1 185 ? 119.977 133.822 119.155 1.00 64.91 ? 185 VAL A C   1 
ATOM   1175 O  O   . VAL A 1 185 ? 119.453 133.782 120.272 1.00 64.91 ? 185 VAL A O   1 
ATOM   1176 C  CB  . VAL A 1 185 ? 120.191 135.961 117.809 1.00 64.91 ? 185 VAL A CB  1 
ATOM   1177 C  CG1 . VAL A 1 185 ? 118.875 136.346 118.339 1.00 64.91 ? 185 VAL A CG1 1 
ATOM   1178 C  CG2 . VAL A 1 185 ? 121.025 137.200 117.647 1.00 64.91 ? 185 VAL A CG2 1 
ATOM   1179 N  N   . PHE A 1 186 ? 119.822 132.840 118.268 1.00 67.38 ? 186 PHE A N   1 
ATOM   1180 C  CA  . PHE A 1 186 ? 118.878 131.757 118.514 1.00 67.38 ? 186 PHE A CA  1 
ATOM   1181 C  C   . PHE A 1 186 ? 119.395 130.750 119.533 1.00 67.38 ? 186 PHE A C   1 
ATOM   1182 O  O   . PHE A 1 186 ? 118.598 130.027 120.139 1.00 67.38 ? 186 PHE A O   1 
ATOM   1183 C  CB  . PHE A 1 186 ? 118.547 131.037 117.212 1.00 67.38 ? 186 PHE A CB  1 
ATOM   1184 C  CG  . PHE A 1 186 ? 117.782 131.868 116.240 1.00 67.38 ? 186 PHE A CG  1 
ATOM   1185 C  CD1 . PHE A 1 186 ? 116.429 132.085 116.417 1.00 67.38 ? 186 PHE A CD1 1 
ATOM   1186 C  CD2 . PHE A 1 186 ? 118.405 132.408 115.132 1.00 67.38 ? 186 PHE A CD2 1 
ATOM   1187 C  CE1 . PHE A 1 186 ? 115.714 132.848 115.518 1.00 67.38 ? 186 PHE A CE1 1 
ATOM   1188 C  CE2 . PHE A 1 186 ? 117.697 133.173 114.226 1.00 67.38 ? 186 PHE A CE2 1 
ATOM   1189 C  CZ  . PHE A 1 186 ? 116.349 133.391 114.419 1.00 67.38 ? 186 PHE A CZ  1 
ATOM   1190 N  N   . ILE A 1 187 ? 120.706 130.661 119.720 1.00 66.83 ? 187 ILE A N   1 
ATOM   1191 C  CA  . ILE A 1 187 ? 121.264 129.685 120.652 1.00 66.83 ? 187 ILE A CA  1 
ATOM   1192 C  C   . ILE A 1 187 ? 121.082 130.266 122.051 1.00 66.83 ? 187 ILE A C   1 
ATOM   1193 O  O   . ILE A 1 187 ? 121.000 131.495 122.197 1.00 66.83 ? 187 ILE A O   1 
ATOM   1194 C  CB  . ILE A 1 187 ? 122.736 129.362 120.310 1.00 66.83 ? 187 ILE A CB  1 
ATOM   1195 C  CG1 . ILE A 1 187 ? 123.217 128.078 120.984 1.00 66.83 ? 187 ILE A CG1 1 
ATOM   1196 C  CG2 . ILE A 1 187 ? 123.679 130.470 120.717 1.00 66.83 ? 187 ILE A CG2 1 
ATOM   1197 C  CD1 . ILE A 1 187 ? 124.542 127.570 120.456 1.00 66.83 ? 187 ILE A CD1 1 
ATOM   1198 N  N   . PRO A 1 188 ? 120.958 129.452 123.100 1.00 65.33 ? 188 PRO A N   1 
ATOM   1199 C  CA  . PRO A 1 188 ? 121.030 130.007 124.456 1.00 65.33 ? 188 PRO A CA  1 
ATOM   1200 C  C   . PRO A 1 188 ? 122.427 130.463 124.836 1.00 65.33 ? 188 PRO A C   1 
ATOM   1201 O  O   . PRO A 1 188 ? 123.345 130.507 124.011 1.00 65.33 ? 188 PRO A O   1 
ATOM   1202 C  CB  . PRO A 1 188 ? 120.569 128.844 125.339 1.00 65.33 ? 188 PRO A CB  1 
ATOM   1203 C  CG  . PRO A 1 188 ? 119.695 128.069 124.473 1.00 65.33 ? 188 PRO A CG  1 
ATOM   1204 C  CD  . PRO A 1 188 ? 120.288 128.142 123.101 1.00 65.33 ? 188 PRO A CD  1 
ATOM   1205 N  N   . SER A 1 189 ? 122.594 130.827 126.097 1.00 66.84 ? 189 SER A N   1 
ATOM   1206 C  CA  . SER A 1 189 ? 123.873 131.361 126.514 1.00 66.84 ? 189 SER A CA  1 
ATOM   1207 C  C   . SER A 1 189 ? 124.893 130.245 126.671 1.00 66.84 ? 189 SER A C   1 
ATOM   1208 O  O   . SER A 1 189 ? 124.551 129.066 126.773 1.00 66.84 ? 189 SER A O   1 
ATOM   1209 C  CB  . SER A 1 189 ? 123.713 132.140 127.808 1.00 66.84 ? 189 SER A CB  1 
ATOM   1210 O  OG  . SER A 1 189 ? 122.817 133.209 127.574 1.00 66.84 ? 189 SER A OG  1 
ATOM   1211 N  N   . PHE A 1 190 ? 126.162 130.636 126.694 1.00 65.74 ? 190 PHE A N   1 
ATOM   1212 C  CA  . PHE A 1 190 ? 127.263 129.683 126.673 1.00 65.74 ? 190 PHE A CA  1 
ATOM   1213 C  C   . PHE A 1 190 ? 127.444 128.988 128.023 1.00 65.74 ? 190 PHE A C   1 
ATOM   1214 O  O   . PHE A 1 190 ? 126.659 129.146 128.962 1.00 65.74 ? 190 PHE A O   1 
ATOM   1215 C  CB  . PHE A 1 190 ? 128.541 130.372 126.225 1.00 65.74 ? 190 PHE A CB  1 
ATOM   1216 C  CG  . PHE A 1 190 ? 128.706 130.433 124.740 1.00 65.74 ? 190 PHE A CG  1 
ATOM   1217 C  CD1 . PHE A 1 190 ? 129.245 129.358 124.049 1.00 65.74 ? 190 PHE A CD1 1 
ATOM   1218 C  CD2 . PHE A 1 190 ? 128.322 131.549 124.030 1.00 65.74 ? 190 PHE A CD2 1 
ATOM   1219 C  CE1 . PHE A 1 190 ? 129.411 129.406 122.675 1.00 65.74 ? 190 PHE A CE1 1 
ATOM   1220 C  CE2 . PHE A 1 190 ? 128.469 131.598 122.657 1.00 65.74 ? 190 PHE A CE2 1 
ATOM   1221 C  CZ  . PHE A 1 190 ? 129.024 130.526 121.981 1.00 65.74 ? 190 PHE A CZ  1 
ATOM   1222 N  N   . HIS A 1 191 ? 128.512 128.206 128.117 1.00 70.27 ? 191 HIS A N   1 
ATOM   1223 C  CA  . HIS A 1 191 ? 128.713 127.240 129.188 1.00 70.27 ? 191 HIS A CA  1 
ATOM   1224 C  C   . HIS A 1 191 ? 130.179 127.273 129.596 1.00 70.27 ? 191 HIS A C   1 
ATOM   1225 O  O   . HIS A 1 191 ? 130.868 128.279 129.400 1.00 70.27 ? 191 HIS A O   1 
ATOM   1226 C  CB  . HIS A 1 191 ? 128.261 125.837 128.772 1.00 70.27 ? 191 HIS A CB  1 
ATOM   1227 C  CG  . HIS A 1 191 ? 126.788 125.624 128.861 1.00 70.27 ? 191 HIS A CG  1 
ATOM   1228 N  ND1 . HIS A 1 191 ? 126.143 125.459 130.065 1.00 70.27 ? 191 HIS A ND1 1 
ATOM   1229 C  CD2 . HIS A 1 191 ? 125.836 125.526 127.905 1.00 70.27 ? 191 HIS A CD2 1 
ATOM   1230 C  CE1 . HIS A 1 191 ? 124.853 125.279 129.850 1.00 70.27 ? 191 HIS A CE1 1 
ATOM   1231 N  NE2 . HIS A 1 191 ? 124.640 125.315 128.547 1.00 70.27 ? 191 HIS A NE2 1 
ATOM   1232 N  N   . ASN A 1 192 ? 130.620 126.179 130.221 1.00 71.87 ? 192 ASN A N   1 
ATOM   1233 C  CA  . ASN A 1 192 ? 131.922 126.109 130.868 1.00 71.87 ? 192 ASN A CA  1 
ATOM   1234 C  C   . ASN A 1 192 ? 133.070 126.370 129.899 1.00 71.87 ? 192 ASN A C   1 
ATOM   1235 O  O   . ASN A 1 192 ? 133.001 126.049 128.712 1.00 71.87 ? 192 ASN A O   1 
ATOM   1236 C  CB  . ASN A 1 192 ? 132.092 124.756 131.584 1.00 71.87 ? 192 ASN A CB  1 
ATOM   1237 C  CG  . ASN A 1 192 ? 131.928 123.530 130.669 1.00 71.87 ? 192 ASN A CG  1 
ATOM   1238 O  OD1 . ASN A 1 192 ? 131.768 123.630 129.454 1.00 71.87 ? 192 ASN A OD1 1 
ATOM   1239 N  ND2 . ASN A 1 192 ? 131.976 122.354 131.279 1.00 71.87 ? 192 ASN A ND2 1 
ATOM   1240 N  N   . TYR A 1 193 ? 134.104 127.033 130.405 1.00 66.20 ? 193 TYR A N   1 
ATOM   1241 C  CA  . TYR A 1 193 ? 135.264 127.401 129.609 1.00 66.20 ? 193 TYR A CA  1 
ATOM   1242 C  C   . TYR A 1 193 ? 136.440 126.467 129.889 1.00 66.20 ? 193 TYR A C   1 
ATOM   1243 O  O   . TYR A 1 193 ? 137.599 126.889 129.948 1.00 66.20 ? 193 TYR A O   1 
ATOM   1244 C  CB  . TYR A 1 193 ? 135.595 128.877 129.856 1.00 66.20 ? 193 TYR A CB  1 
ATOM   1245 C  CG  . TYR A 1 193 ? 136.576 129.488 128.890 1.00 66.20 ? 193 TYR A CG  1 
ATOM   1246 C  CD1 . TYR A 1 193 ? 136.307 129.505 127.540 1.00 66.20 ? 193 TYR A CD1 1 
ATOM   1247 C  CD2 . TYR A 1 193 ? 137.734 130.100 129.334 1.00 66.20 ? 193 TYR A CD2 1 
ATOM   1248 C  CE1 . TYR A 1 193 ? 137.185 130.052 126.638 1.00 66.20 ? 193 TYR A CE1 1 
ATOM   1249 C  CE2 . TYR A 1 193 ? 138.619 130.676 128.439 1.00 66.20 ? 193 TYR A CE2 1 
ATOM   1250 C  CZ  . TYR A 1 193 ? 138.333 130.641 127.086 1.00 66.20 ? 193 TYR A CZ  1 
ATOM   1251 O  OH  . TYR A 1 193 ? 139.186 131.196 126.162 1.00 66.20 ? 193 TYR A OH  1 
ATOM   1252 N  N   . ARG A 1 194 ? 136.151 125.183 130.074 1.00 67.17 ? 194 ARG A N   1 
ATOM   1253 C  CA  . ARG A 1 194 ? 137.190 124.206 130.349 1.00 67.17 ? 194 ARG A CA  1 
ATOM   1254 C  C   . ARG A 1 194 ? 137.734 123.569 129.089 1.00 67.17 ? 194 ARG A C   1 
ATOM   1255 O  O   . ARG A 1 194 ? 138.911 123.744 128.785 1.00 67.17 ? 194 ARG A O   1 
ATOM   1256 C  CB  . ARG A 1 194 ? 136.665 123.113 131.283 1.00 67.17 ? 194 ARG A CB  1 
ATOM   1257 C  CG  . ARG A 1 194 ? 137.731 122.106 131.709 1.00 67.17 ? 194 ARG A CG  1 
ATOM   1258 C  CD  . ARG A 1 194 ? 137.197 121.121 132.739 1.00 67.17 ? 194 ARG A CD  1 
ATOM   1259 N  NE  . ARG A 1 194 ? 138.228 120.226 133.247 1.00 67.17 ? 194 ARG A NE  1 
ATOM   1260 C  CZ  . ARG A 1 194 ? 138.514 119.044 132.720 1.00 67.17 ? 194 ARG A CZ  1 
ATOM   1261 N  NH1 . ARG A 1 194 ? 139.465 118.294 133.252 1.00 67.17 ? 194 ARG A NH1 1 
ATOM   1262 N  NH2 . ARG A 1 194 ? 137.846 118.614 131.662 1.00 67.17 ? 194 ARG A NH2 1 
ATOM   1263 N  N   . ILE A 1 195 ? 136.901 122.869 128.321 1.00 64.26 ? 195 ILE A N   1 
ATOM   1264 C  CA  . ILE A 1 195 ? 137.417 122.148 127.165 1.00 64.26 ? 195 ILE A CA  1 
ATOM   1265 C  C   . ILE A 1 195 ? 137.691 123.104 126.008 1.00 64.26 ? 195 ILE A C   1 
ATOM   1266 O  O   . ILE A 1 195 ? 138.412 122.756 125.067 1.00 64.26 ? 195 ILE A O   1 
ATOM   1267 C  CB  . ILE A 1 195 ? 136.448 121.015 126.779 1.00 64.26 ? 195 ILE A CB  1 
ATOM   1268 C  CG1 . ILE A 1 195 ? 137.154 119.954 125.939 1.00 64.26 ? 195 ILE A CG1 1 
ATOM   1269 C  CG2 . ILE A 1 195 ? 135.248 121.552 126.036 1.00 64.26 ? 195 ILE A CG2 1 
ATOM   1270 C  CD1 . ILE A 1 195 ? 138.237 119.228 126.683 1.00 64.26 ? 195 ILE A CD1 1 
ATOM   1271 N  N   . TRP A 1 196 ? 137.182 124.335 126.071 1.00 63.51 ? 196 TRP A N   1 
ATOM   1272 C  CA  . TRP A 1 196 ? 137.524 125.341 125.077 1.00 63.51 ? 196 TRP A CA  1 
ATOM   1273 C  C   . TRP A 1 196 ? 138.832 126.042 125.387 1.00 63.51 ? 196 TRP A C   1 
ATOM   1274 O  O   . TRP A 1 196 ? 139.194 126.987 124.684 1.00 63.51 ? 196 TRP A O   1 
ATOM   1275 C  CB  . TRP A 1 196 ? 136.434 126.403 124.944 1.00 63.51 ? 196 TRP A CB  1 
ATOM   1276 C  CG  . TRP A 1 196 ? 135.104 125.920 124.536 1.00 63.51 ? 196 TRP A CG  1 
ATOM   1277 C  CD1 . TRP A 1 196 ? 133.981 125.923 125.291 1.00 63.51 ? 196 TRP A CD1 1 
ATOM   1278 C  CD2 . TRP A 1 196 ? 134.753 125.314 123.294 1.00 63.51 ? 196 TRP A CD2 1 
ATOM   1279 N  NE1 . TRP A 1 196 ? 132.936 125.392 124.588 1.00 63.51 ? 196 TRP A NE1 1 
ATOM   1280 C  CE2 . TRP A 1 196 ? 133.387 125.003 123.357 1.00 63.51 ? 196 TRP A CE2 1 
ATOM   1281 C  CE3 . TRP A 1 196 ? 135.461 125.009 122.132 1.00 63.51 ? 196 TRP A CE3 1 
ATOM   1282 C  CZ2 . TRP A 1 196 ? 132.711 124.400 122.306 1.00 63.51 ? 196 TRP A CZ2 1 
ATOM   1283 C  CZ3 . TRP A 1 196 ? 134.791 124.409 121.091 1.00 63.51 ? 196 TRP A CZ3 1 
ATOM   1284 C  CH2 . TRP A 1 196 ? 133.428 124.113 121.183 1.00 63.51 ? 196 TRP A CH2 1 
ATOM   1285 N  N   . SER A 1 197 ? 139.534 125.628 126.435 1.00 60.09 ? 197 SER A N   1 
ATOM   1286 C  CA  . SER A 1 197 ? 140.818 126.211 126.775 1.00 60.09 ? 197 SER A CA  1 
ATOM   1287 C  C   . SER A 1 197 ? 141.969 125.236 126.627 1.00 60.09 ? 197 SER A C   1 
ATOM   1288 O  O   . SER A 1 197 ? 143.123 125.665 126.604 1.00 60.09 ? 197 SER A O   1 
ATOM   1289 C  CB  . SER A 1 197 ? 140.788 126.730 128.210 1.00 60.09 ? 197 SER A CB  1 
ATOM   1290 O  OG  . SER A 1 197 ? 139.798 127.723 128.336 1.00 60.09 ? 197 SER A OG  1 
ATOM   1291 N  N   . PHE A 1 198 ? 141.680 123.940 126.565 1.00 60.23 ? 198 PHE A N   1 
ATOM   1292 C  CA  . PHE A 1 198 ? 142.670 122.972 126.132 1.00 60.23 ? 198 PHE A CA  1 
ATOM   1293 C  C   . PHE A 1 198 ? 142.811 123.003 124.620 1.00 60.23 ? 198 PHE A C   1 
ATOM   1294 O  O   . PHE A 1 198 ? 143.848 122.615 124.077 1.00 60.23 ? 198 PHE A O   1 
ATOM   1295 C  CB  . PHE A 1 198 ? 142.271 121.568 126.586 1.00 60.23 ? 198 PHE A CB  1 
ATOM   1296 C  CG  . PHE A 1 198 ? 142.117 121.426 128.070 1.00 60.23 ? 198 PHE A CG  1 
ATOM   1297 C  CD1 . PHE A 1 198 ? 143.219 121.462 128.898 1.00 60.23 ? 198 PHE A CD1 1 
ATOM   1298 C  CD2 . PHE A 1 198 ? 140.876 121.193 128.631 1.00 60.23 ? 198 PHE A CD2 1 
ATOM   1299 C  CE1 . PHE A 1 198 ? 143.085 121.315 130.256 1.00 60.23 ? 198 PHE A CE1 1 
ATOM   1300 C  CE2 . PHE A 1 198 ? 140.739 121.043 129.994 1.00 60.23 ? 198 PHE A CE2 1 
ATOM   1301 C  CZ  . PHE A 1 198 ? 141.846 121.103 130.804 1.00 60.23 ? 198 PHE A CZ  1 
ATOM   1302 N  N   . LEU A 1 199 ? 141.767 123.436 123.925 1.00 55.23 ? 199 LEU A N   1 
ATOM   1303 C  CA  . LEU A 1 199 ? 141.794 123.500 122.477 1.00 55.23 ? 199 LEU A CA  1 
ATOM   1304 C  C   . LEU A 1 199 ? 142.076 124.894 121.946 1.00 55.23 ? 199 LEU A C   1 
ATOM   1305 O  O   . LEU A 1 199 ? 142.610 125.011 120.844 1.00 55.23 ? 199 LEU A O   1 
ATOM   1306 C  CB  . LEU A 1 199 ? 140.469 123.013 121.909 1.00 55.23 ? 199 LEU A CB  1 
ATOM   1307 C  CG  . LEU A 1 199 ? 140.083 121.574 122.237 1.00 55.23 ? 199 LEU A CG  1 
ATOM   1308 C  CD1 . LEU A 1 199 ? 138.708 121.257 121.666 1.00 55.23 ? 199 LEU A CD1 1 
ATOM   1309 C  CD2 . LEU A 1 199 ? 141.124 120.584 121.745 1.00 55.23 ? 199 LEU A CD2 1 
ATOM   1310 N  N   . GLY A 1 200 ? 141.721 125.946 122.672 1.00 49.49 ? 200 GLY A N   1 
ATOM   1311 C  CA  . GLY A 1 200 ? 141.976 127.290 122.200 1.00 49.49 ? 200 GLY A CA  1 
ATOM   1312 C  C   . GLY A 1 200 ? 143.446 127.635 122.251 1.00 49.49 ? 200 GLY A C   1 
ATOM   1313 O  O   . GLY A 1 200 ? 143.971 128.258 121.331 1.00 49.49 ? 200 GLY A O   1 
ATOM   1314 N  N   . LEU A 1 201 ? 144.122 127.228 123.327 1.00 47.87 ? 201 LEU A N   1 
ATOM   1315 C  CA  . LEU A 1 201 ? 145.563 127.422 123.459 1.00 47.87 ? 201 LEU A CA  1 
ATOM   1316 C  C   . LEU A 1 201 ? 146.297 126.515 122.477 1.00 47.87 ? 201 LEU A C   1 
ATOM   1317 O  O   . LEU A 1 201 ? 147.323 126.910 121.920 1.00 47.87 ? 201 LEU A O   1 
ATOM   1318 C  CB  . LEU A 1 201 ? 145.958 127.309 124.931 1.00 47.87 ? 201 LEU A CB  1 
ATOM   1319 C  CG  . LEU A 1 201 ? 147.351 127.694 125.401 1.00 47.87 ? 201 LEU A CG  1 
ATOM   1320 C  CD1 . LEU A 1 201 ? 147.577 129.154 125.131 1.00 47.87 ? 201 LEU A CD1 1 
ATOM   1321 C  CD2 . LEU A 1 201 ? 147.502 127.413 126.864 1.00 47.87 ? 201 LEU A CD2 1 
ATOM   1322 N  N   . GLY A 1 202 ? 145.787 125.309 122.241 1.00 46.96 ? 202 GLY A N   1 
ATOM   1323 C  CA  . GLY A 1 202 ? 146.376 124.459 121.223 1.00 46.96 ? 202 GLY A CA  1 
ATOM   1324 C  C   . GLY A 1 202 ? 146.567 125.216 119.923 1.00 46.96 ? 202 GLY A C   1 
ATOM   1325 O  O   . GLY A 1 202 ? 147.657 125.200 119.344 1.00 46.96 ? 202 GLY A O   1 
ATOM   1326 N  N   . MET A 1 203 ? 145.510 125.862 119.427 1.00 46.62 ? 203 MET A N   1 
ATOM   1327 C  CA  . MET A 1 203 ? 145.583 126.596 118.172 1.00 46.62 ? 203 MET A CA  1 
ATOM   1328 C  C   . MET A 1 203 ? 146.326 127.914 118.021 1.00 46.62 ? 203 MET A C   1 
ATOM   1329 O  O   . MET A 1 203 ? 146.693 128.263 116.897 1.00 46.62 ? 203 MET A O   1 
ATOM   1330 C  CB  . MET A 1 203 ? 144.123 126.770 117.749 1.00 46.62 ? 203 MET A CB  1 
ATOM   1331 C  CG  . MET A 1 203 ? 143.367 125.461 117.694 1.00 46.62 ? 203 MET A CG  1 
ATOM   1332 S  SD  . MET A 1 203 ? 141.697 125.606 117.068 1.00 46.62 ? 203 MET A SD  1 
ATOM   1333 C  CE  . MET A 1 203 ? 140.905 126.483 118.401 1.00 46.62 ? 203 MET A CE  1 
ATOM   1334 N  N   . THR A 1 204 ? 146.544 128.666 119.103 1.00 45.75 ? 204 THR A N   1 
ATOM   1335 C  CA  . THR A 1 204 ? 147.508 129.761 119.090 1.00 45.75 ? 204 THR A CA  1 
ATOM   1336 C  C   . THR A 1 204 ? 148.961 129.394 119.307 1.00 45.75 ? 204 THR A C   1 
ATOM   1337 O  O   . THR A 1 204 ? 149.850 130.127 118.873 1.00 45.75 ? 204 THR A O   1 
ATOM   1338 C  CB  . THR A 1 204 ? 147.003 131.008 119.810 1.00 45.75 ? 204 THR A CB  1 
ATOM   1339 O  OG1 . THR A 1 204 ? 146.592 130.686 121.138 1.00 45.75 ? 204 THR A OG1 1 
ATOM   1340 C  CG2 . THR A 1 204 ? 145.889 131.636 119.057 1.00 45.75 ? 204 THR A CG2 1 
ATOM   1341 N  N   . THR A 1 205 ? 149.228 128.291 119.990 1.00 45.70 ? 205 THR A N   1 
ATOM   1342 C  CA  . THR A 1 205 ? 150.528 127.655 119.883 1.00 45.70 ? 205 THR A CA  1 
ATOM   1343 C  C   . THR A 1 205 ? 151.179 127.373 118.547 1.00 45.70 ? 205 THR A C   1 
ATOM   1344 O  O   . THR A 1 205 ? 152.316 127.783 118.321 1.00 45.70 ? 205 THR A O   1 
ATOM   1345 C  CB  . THR A 1 205 ? 150.602 126.406 120.759 1.00 45.70 ? 205 THR A CB  1 
ATOM   1346 O  OG1 . THR A 1 205 ? 149.946 126.670 122.002 1.00 45.70 ? 205 THR A OG1 1 
ATOM   1347 C  CG2 . THR A 1 205 ? 152.040 126.036 121.044 1.00 45.70 ? 205 THR A CG2 1 
ATOM   1348 N  N   . TYR A 1 206 ? 150.455 126.713 117.649 1.00 44.55 ? 206 TYR A N   1 
ATOM   1349 C  CA  . TYR A 1 206 ? 150.981 126.415 116.327 1.00 44.55 ? 206 TYR A CA  1 
ATOM   1350 C  C   . TYR A 1 206 ? 151.150 127.675 115.495 1.00 44.55 ? 206 TYR A C   1 
ATOM   1351 O  O   . TYR A 1 206 ? 152.165 127.842 114.815 1.00 44.55 ? 206 TYR A O   1 
ATOM   1352 C  CB  . TYR A 1 206 ? 150.068 125.436 115.614 1.00 44.55 ? 206 TYR A CB  1 
ATOM   1353 C  CG  . TYR A 1 206 ? 150.551 125.095 114.248 1.00 44.55 ? 206 TYR A CG  1 
ATOM   1354 C  CD1 . TYR A 1 206 ? 151.658 124.295 114.075 1.00 44.55 ? 206 TYR A CD1 1 
ATOM   1355 C  CD2 . TYR A 1 206 ? 149.885 125.545 113.130 1.00 44.55 ? 206 TYR A CD2 1 
ATOM   1356 C  CE1 . TYR A 1 206 ? 152.098 123.971 112.827 1.00 44.55 ? 206 TYR A CE1 1 
ATOM   1357 C  CE2 . TYR A 1 206 ? 150.320 125.228 111.881 1.00 44.55 ? 206 TYR A CE2 1 
ATOM   1358 C  CZ  . TYR A 1 206 ? 151.421 124.437 111.737 1.00 44.55 ? 206 TYR A CZ  1 
ATOM   1359 O  OH  . TYR A 1 206 ? 151.853 124.119 110.482 1.00 44.55 ? 206 TYR A OH  1 
ATOM   1360 N  N   . THR A 1 207 ? 150.166 128.568 115.525 1.00 44.87 ? 207 THR A N   1 
ATOM   1361 C  CA  . THR A 1 207 ? 150.229 129.792 114.738 1.00 44.87 ? 207 THR A CA  1 
ATOM   1362 C  C   . THR A 1 207 ? 151.313 130.744 115.233 1.00 44.87 ? 207 THR A C   1 
ATOM   1363 O  O   . THR A 1 207 ? 151.860 131.504 114.432 1.00 44.87 ? 207 THR A O   1 
ATOM   1364 C  CB  . THR A 1 207 ? 148.859 130.471 114.742 1.00 44.87 ? 207 THR A CB  1 
ATOM   1365 O  OG1 . THR A 1 207 ? 147.878 129.493 114.416 1.00 44.87 ? 207 THR A OG1 1 
ATOM   1366 C  CG2 . THR A 1 207 ? 148.763 131.538 113.683 1.00 44.87 ? 207 THR A CG2 1 
ATOM   1367 N  N   . ALA A 1 208 ? 151.696 130.686 116.506 1.00 43.95 ? 208 ALA A N   1 
ATOM   1368 C  CA  . ALA A 1 208 ? 152.789 131.534 116.960 1.00 43.95 ? 208 ALA A CA  1 
ATOM   1369 C  C   . ALA A 1 208 ? 154.140 130.949 116.583 1.00 43.95 ? 208 ALA A C   1 
ATOM   1370 O  O   . ALA A 1 208 ? 155.123 131.682 116.459 1.00 43.95 ? 208 ALA A O   1 
ATOM   1371 C  CB  . ALA A 1 208 ? 152.704 131.749 118.461 1.00 43.95 ? 208 ALA A CB  1 
ATOM   1372 N  N   . TRP A 1 209 ? 154.224 129.635 116.422 1.00 47.31 ? 209 TRP A N   1 
ATOM   1373 C  CA  . TRP A 1 209 ? 155.439 129.038 115.882 1.00 47.31 ? 209 TRP A CA  1 
ATOM   1374 C  C   . TRP A 1 209 ? 155.325 128.686 114.404 1.00 47.31 ? 209 TRP A C   1 
ATOM   1375 O  O   . TRP A 1 209 ? 156.312 128.235 113.825 1.00 47.31 ? 209 TRP A O   1 
ATOM   1376 C  CB  . TRP A 1 209 ? 155.851 127.782 116.657 1.00 47.31 ? 209 TRP A CB  1 
ATOM   1377 C  CG  . TRP A 1 209 ? 156.262 128.016 118.068 1.00 47.31 ? 209 TRP A CG  1 
ATOM   1378 C  CD1 . TRP A 1 209 ? 155.524 127.772 119.177 1.00 47.31 ? 209 TRP A CD1 1 
ATOM   1379 C  CD2 . TRP A 1 209 ? 157.506 128.546 118.525 1.00 47.31 ? 209 TRP A CD2 1 
ATOM   1380 N  NE1 . TRP A 1 209 ? 156.226 128.111 120.300 1.00 47.31 ? 209 TRP A NE1 1 
ATOM   1381 C  CE2 . TRP A 1 209 ? 157.449 128.593 119.924 1.00 47.31 ? 209 TRP A CE2 1 
ATOM   1382 C  CE3 . TRP A 1 209 ? 158.667 128.980 117.886 1.00 47.31 ? 209 TRP A CE3 1 
ATOM   1383 C  CZ2 . TRP A 1 209 ? 158.501 129.056 120.696 1.00 47.31 ? 209 TRP A CZ2 1 
ATOM   1384 C  CZ3 . TRP A 1 209 ? 159.713 129.445 118.657 1.00 47.31 ? 209 TRP A CZ3 1 
ATOM   1385 C  CH2 . TRP A 1 209 ? 159.623 129.479 120.044 1.00 47.31 ? 209 TRP A CH2 1 
ATOM   1386 N  N   . TYR A 1 210 ? 154.161 128.840 113.777 1.00 43.51 ? 210 TYR A N   1 
ATOM   1387 C  CA  . TYR A 1 210 ? 154.174 128.891 112.324 1.00 43.51 ? 210 TYR A CA  1 
ATOM   1388 C  C   . TYR A 1 210 ? 154.862 130.153 111.838 1.00 43.51 ? 210 TYR A C   1 
ATOM   1389 O  O   . TYR A 1 210 ? 155.697 130.089 110.936 1.00 43.51 ? 210 TYR A O   1 
ATOM   1390 C  CB  . TYR A 1 210 ? 152.769 128.810 111.740 1.00 43.51 ? 210 TYR A CB  1 
ATOM   1391 C  CG  . TYR A 1 210 ? 152.760 129.180 110.277 1.00 43.51 ? 210 TYR A CG  1 
ATOM   1392 C  CD1 . TYR A 1 210 ? 153.356 128.364 109.332 1.00 43.51 ? 210 TYR A CD1 1 
ATOM   1393 C  CD2 . TYR A 1 210 ? 152.153 130.350 109.842 1.00 43.51 ? 210 TYR A CD2 1 
ATOM   1394 C  CE1 . TYR A 1 210 ? 153.366 128.703 108.012 1.00 43.51 ? 210 TYR A CE1 1 
ATOM   1395 C  CE2 . TYR A 1 210 ? 152.158 130.695 108.518 1.00 43.51 ? 210 TYR A CE2 1 
ATOM   1396 C  CZ  . TYR A 1 210 ? 152.770 129.866 107.614 1.00 43.51 ? 210 TYR A CZ  1 
ATOM   1397 O  OH  . TYR A 1 210 ? 152.782 130.200 106.290 1.00 43.51 ? 210 TYR A OH  1 
ATOM   1398 N  N   . LEU A 1 211 ? 154.515 131.310 112.412 1.00 43.76 ? 211 LEU A N   1 
ATOM   1399 C  CA  . LEU A 1 211 ? 155.075 132.570 111.944 1.00 43.76 ? 211 LEU A CA  1 
ATOM   1400 C  C   . LEU A 1 211 ? 156.552 132.680 112.269 1.00 43.76 ? 211 LEU A C   1 
ATOM   1401 O  O   . LEU A 1 211 ? 157.325 133.177 111.449 1.00 43.76 ? 211 LEU A O   1 
ATOM   1402 C  CB  . LEU A 1 211 ? 154.330 133.748 112.558 1.00 43.76 ? 211 LEU A CB  1 
ATOM   1403 C  CG  . LEU A 1 211 ? 152.822 133.914 112.372 1.00 43.76 ? 211 LEU A CG  1 
ATOM   1404 C  CD1 . LEU A 1 211 ? 152.324 135.122 113.151 1.00 43.76 ? 211 LEU A CD1 1 
ATOM   1405 C  CD2 . LEU A 1 211 ? 152.420 134.013 110.941 1.00 43.76 ? 211 LEU A CD2 1 
ATOM   1406 N  N   . ALA A 1 212 ? 156.970 132.174 113.429 1.00 47.31 ? 212 ALA A N   1 
ATOM   1407 C  CA  . ALA A 1 212 ? 158.339 132.386 113.888 1.00 47.31 ? 212 ALA A CA  1 
ATOM   1408 C  C   . ALA A 1 212 ? 159.324 131.498 113.142 1.00 47.31 ? 212 ALA A C   1 
ATOM   1409 O  O   . ALA A 1 212 ? 160.431 131.928 112.809 1.00 47.31 ? 212 ALA A O   1 
ATOM   1410 C  CB  . ALA A 1 212 ? 158.436 132.138 115.391 1.00 47.31 ? 212 ALA A CB  1 
ATOM   1411 N  N   . ILE A 1 213 ? 158.943 130.251 112.876 1.00 48.66 ? 213 ILE A N   1 
ATOM   1412 C  CA  . ILE A 1 213 ? 159.856 129.337 112.208 1.00 48.66 ? 213 ILE A CA  1 
ATOM   1413 C  C   . ILE A 1 213 ? 159.861 129.577 110.707 1.00 48.66 ? 213 ILE A C   1 
ATOM   1414 O  O   . ILE A 1 213 ? 160.925 129.616 110.082 1.00 48.66 ? 213 ILE A O   1 
ATOM   1415 C  CB  . ILE A 1 213 ? 159.500 127.888 112.554 1.00 48.66 ? 213 ILE A CB  1 
ATOM   1416 C  CG1 . ILE A 1 213 ? 159.568 127.693 114.063 1.00 48.66 ? 213 ILE A CG1 1 
ATOM   1417 C  CG2 . ILE A 1 213 ? 160.449 126.940 111.880 1.00 48.66 ? 213 ILE A CG2 1 
ATOM   1418 C  CD1 . ILE A 1 213 ? 160.917 127.977 114.643 1.00 48.66 ? 213 ILE A CD1 1 
ATOM   1419 N  N   . ALA A 1 214 ? 158.691 129.791 110.101 1.00 46.75 ? 214 ALA A N   1 
ATOM   1420 C  CA  . ALA A 1 214 ? 158.635 129.991 108.656 1.00 46.75 ? 214 ALA A CA  1 
ATOM   1421 C  C   . ALA A 1 214 ? 158.997 131.404 108.222 1.00 46.75 ? 214 ALA A C   1 
ATOM   1422 O  O   . ALA A 1 214 ? 158.634 131.792 107.111 1.00 46.75 ? 214 ALA A O   1 
ATOM   1423 C  CB  . ALA A 1 214 ? 157.255 129.635 108.108 1.00 46.75 ? 214 ALA A CB  1 
ATOM   1424 N  N   . SER A 1 215 ? 159.670 132.190 109.060 1.00 48.80 ? 215 SER A N   1 
ATOM   1425 C  CA  . SER A 1 215 ? 160.240 133.469 108.662 1.00 48.80 ? 215 SER A CA  1 
ATOM   1426 C  C   . SER A 1 215 ? 161.751 133.531 108.823 1.00 48.80 ? 215 SER A C   1 
ATOM   1427 O  O   . SER A 1 215 ? 162.410 134.278 108.100 1.00 48.80 ? 215 SER A O   1 
ATOM   1428 C  CB  . SER A 1 215 ? 159.601 134.602 109.452 1.00 48.80 ? 215 SER A CB  1 
ATOM   1429 O  OG  . SER A 1 215 ? 158.238 134.715 109.108 1.00 48.80 ? 215 SER A OG  1 
ATOM   1430 N  N   . ILE A 1 216 ? 162.318 132.781 109.768 1.00 48.27 ? 216 ILE A N   1 
ATOM   1431 C  CA  . ILE A 1 216 ? 163.769 132.644 109.826 1.00 48.27 ? 216 ILE A CA  1 
ATOM   1432 C  C   . ILE A 1 216 ? 164.265 131.781 108.668 1.00 48.27 ? 216 ILE A C   1 
ATOM   1433 O  O   . ILE A 1 216 ? 165.357 132.012 108.134 1.00 48.27 ? 216 ILE A O   1 
ATOM   1434 C  CB  . ILE A 1 216 ? 164.175 132.090 111.204 1.00 48.27 ? 216 ILE A CB  1 
ATOM   1435 C  CG1 . ILE A 1 216 ? 163.800 133.091 112.286 1.00 48.27 ? 216 ILE A CG1 1 
ATOM   1436 C  CG2 . ILE A 1 216 ? 165.655 131.852 111.309 1.00 48.27 ? 216 ILE A CG2 1 
ATOM   1437 C  CD1 . ILE A 1 216 ? 163.958 132.558 113.684 1.00 48.27 ? 216 ILE A CD1 1 
ATOM   1438 N  N   . ILE A 1 217 ? 163.465 130.802 108.240 1.00 48.76 ? 217 ILE A N   1 
ATOM   1439 C  CA  . ILE A 1 217 ? 163.786 130.025 107.047 1.00 48.76 ? 217 ILE A CA  1 
ATOM   1440 C  C   . ILE A 1 217 ? 163.782 130.904 105.807 1.00 48.76 ? 217 ILE A C   1 
ATOM   1441 O  O   . ILE A 1 217 ? 164.708 130.843 104.989 1.00 48.76 ? 217 ILE A O   1 
ATOM   1442 C  CB  . ILE A 1 217 ? 162.790 128.863 106.904 1.00 48.76 ? 217 ILE A CB  1 
ATOM   1443 C  CG1 . ILE A 1 217 ? 162.952 127.890 108.059 1.00 48.76 ? 217 ILE A CG1 1 
ATOM   1444 C  CG2 . ILE A 1 217 ? 162.974 128.145 105.593 1.00 48.76 ? 217 ILE A CG2 1 
ATOM   1445 C  CD1 . ILE A 1 217 ? 161.892 126.834 108.100 1.00 48.76 ? 217 ILE A CD1 1 
ATOM   1446 N  N   . HIS A 1 218 ? 162.762 131.751 105.668 1.00 50.10 ? 218 HIS A N   1 
ATOM   1447 C  CA  . HIS A 1 218 ? 162.597 132.584 104.482 1.00 50.10 ? 218 HIS A CA  1 
ATOM   1448 C  C   . HIS A 1 218 ? 163.692 133.628 104.353 1.00 50.10 ? 218 HIS A C   1 
ATOM   1449 O  O   . HIS A 1 218 ? 164.128 133.922 103.238 1.00 50.10 ? 218 HIS A O   1 
ATOM   1450 C  CB  . HIS A 1 218 ? 161.230 133.253 104.525 1.00 50.10 ? 218 HIS A CB  1 
ATOM   1451 C  CG  . HIS A 1 218 ? 161.000 134.225 103.421 1.00 50.10 ? 218 HIS A CG  1 
ATOM   1452 N  ND1 . HIS A 1 218 ? 160.750 133.834 102.126 1.00 50.10 ? 218 HIS A ND1 1 
ATOM   1453 C  CD2 . HIS A 1 218 ? 160.978 135.576 103.420 1.00 50.10 ? 218 HIS A CD2 1 
ATOM   1454 C  CE1 . HIS A 1 218 ? 160.584 134.906 101.372 1.00 50.10 ? 218 HIS A CE1 1 
ATOM   1455 N  NE2 . HIS A 1 218 ? 160.718 135.975 102.134 1.00 50.10 ? 218 HIS A NE2 1 
ATOM   1456 N  N   . GLY A 1 219 ? 164.139 134.198 105.458 1.00 51.87 ? 219 GLY A N   1 
ATOM   1457 C  CA  . GLY A 1 219 ? 165.314 135.041 105.449 1.00 51.87 ? 219 GLY A CA  1 
ATOM   1458 C  C   . GLY A 1 219 ? 165.061 136.415 104.857 1.00 51.87 ? 219 GLY A C   1 
ATOM   1459 O  O   . GLY A 1 219 ? 164.012 136.702 104.286 1.00 51.87 ? 219 GLY A O   1 
ATOM   1460 N  N   . GLN A 1 220 ? 166.058 137.282 105.012 1.00 55.82 ? 220 GLN A N   1 
ATOM   1461 C  CA  . GLN A 1 220 ? 165.937 138.651 104.537 1.00 55.82 ? 220 GLN A CA  1 
ATOM   1462 C  C   . GLN A 1 220 ? 165.969 138.702 103.017 1.00 55.82 ? 220 GLN A C   1 
ATOM   1463 O  O   . GLN A 1 220 ? 166.463 137.786 102.355 1.00 55.82 ? 220 GLN A O   1 
ATOM   1464 C  CB  . GLN A 1 220 ? 167.064 139.520 105.089 1.00 55.82 ? 220 GLN A CB  1 
ATOM   1465 C  CG  . GLN A 1 220 ? 167.061 139.738 106.578 1.00 55.82 ? 220 GLN A CG  1 
ATOM   1466 C  CD  . GLN A 1 220 ? 168.190 140.650 107.005 1.00 55.82 ? 220 GLN A CD  1 
ATOM   1467 O  OE1 . GLN A 1 220 ? 168.975 141.103 106.178 1.00 55.82 ? 220 GLN A OE1 1 
ATOM   1468 N  NE2 . GLN A 1 220 ? 168.290 140.908 108.298 1.00 55.82 ? 220 GLN A NE2 1 
ATOM   1469 N  N   . ALA A 1 221 ? 165.409 139.772 102.467 1.00 63.81 ? 221 ALA A N   1 
ATOM   1470 C  CA  . ALA A 1 221 ? 165.694 140.140 101.093 1.00 63.81 ? 221 ALA A CA  1 
ATOM   1471 C  C   . ALA A 1 221 ? 166.943 141.013 101.052 1.00 63.81 ? 221 ALA A C   1 
ATOM   1472 O  O   . ALA A 1 221 ? 167.614 141.228 102.064 1.00 63.81 ? 221 ALA A O   1 
ATOM   1473 C  CB  . ALA A 1 221 ? 164.511 140.873 100.466 1.00 63.81 ? 221 ALA A CB  1 
ATOM   1474 N  N   . GLU A 1 222 ? 167.249 141.526 99.864  1.00 70.53 ? 222 GLU A N   1 
ATOM   1475 C  CA  . GLU A 1 222 ? 168.452 142.332 99.687  1.00 70.53 ? 222 GLU A CA  1 
ATOM   1476 C  C   . GLU A 1 222 ? 168.314 143.722 100.295 1.00 70.53 ? 222 GLU A C   1 
ATOM   1477 O  O   . GLU A 1 222 ? 169.162 144.138 101.091 1.00 70.53 ? 222 GLU A O   1 
ATOM   1478 C  CB  . GLU A 1 222 ? 168.808 142.442 98.202  1.00 70.53 ? 222 GLU A CB  1 
ATOM   1479 C  CG  . GLU A 1 222 ? 169.350 141.157 97.590  1.00 70.53 ? 222 GLU A CG  1 
ATOM   1480 C  CD  . GLU A 1 222 ? 168.261 140.203 97.142  1.00 70.53 ? 222 GLU A CD  1 
ATOM   1481 O  OE1 . GLU A 1 222 ? 167.068 140.565 97.237  1.00 70.53 ? 222 GLU A OE1 1 
ATOM   1482 O  OE2 . GLU A 1 222 ? 168.600 139.087 96.696  1.00 70.53 ? 222 GLU A OE2 1 
ATOM   1483 N  N   . GLY A 1 223 ? 167.263 144.450 99.925  1.00 64.50 ? 223 GLY A N   1 
ATOM   1484 C  CA  . GLY A 1 223 ? 167.146 145.835 100.332 1.00 64.50 ? 223 GLY A CA  1 
ATOM   1485 C  C   . GLY A 1 223 ? 166.027 146.181 101.293 1.00 64.50 ? 223 GLY A C   1 
ATOM   1486 O  O   . GLY A 1 223 ? 165.432 147.254 101.172 1.00 64.50 ? 223 GLY A O   1 
ATOM   1487 N  N   . VAL A 1 224 ? 165.731 145.316 102.257 1.00 60.71 ? 224 VAL A N   1 
ATOM   1488 C  CA  . VAL A 1 224 ? 164.699 145.614 103.242 1.00 60.71 ? 224 VAL A CA  1 
ATOM   1489 C  C   . VAL A 1 224 ? 165.304 146.487 104.324 1.00 60.71 ? 224 VAL A C   1 
ATOM   1490 O  O   . VAL A 1 224 ? 166.496 146.401 104.632 1.00 60.71 ? 224 VAL A O   1 
ATOM   1491 C  CB  . VAL A 1 224 ? 164.065 144.346 103.844 1.00 60.71 ? 224 VAL A CB  1 
ATOM   1492 C  CG1 . VAL A 1 224 ? 163.300 143.603 102.790 1.00 60.71 ? 224 VAL A CG1 1 
ATOM   1493 C  CG2 . VAL A 1 224 ? 165.124 143.459 104.423 1.00 60.71 ? 224 VAL A CG2 1 
ATOM   1494 N  N   . LYS A 1 225 ? 164.479 147.354 104.891 1.00 56.69 ? 225 LYS A N   1 
ATOM   1495 C  CA  . LYS A 1 225 ? 164.950 148.399 105.781 1.00 56.69 ? 225 LYS A CA  1 
ATOM   1496 C  C   . LYS A 1 225 ? 164.318 148.244 107.154 1.00 56.69 ? 225 LYS A C   1 
ATOM   1497 O  O   . LYS A 1 225 ? 163.147 147.891 107.272 1.00 56.69 ? 225 LYS A O   1 
ATOM   1498 C  CB  . LYS A 1 225 ? 164.614 149.767 105.213 1.00 56.69 ? 225 LYS A CB  1 
ATOM   1499 C  CG  . LYS A 1 225 ? 165.331 150.065 103.927 1.00 56.69 ? 225 LYS A CG  1 
ATOM   1500 C  CD  . LYS A 1 225 ? 164.947 151.411 103.383 1.00 56.69 ? 225 LYS A CD  1 
ATOM   1501 C  CE  . LYS A 1 225 ? 163.896 151.260 102.300 1.00 56.69 ? 225 LYS A CE  1 
ATOM   1502 N  NZ  . LYS A 1 225 ? 162.549 150.899 102.831 1.00 56.69 ? 225 LYS A NZ  1 
ATOM   1503 N  N   . HIS A 1 226 ? 165.099 148.518 108.193 1.00 52.86 ? 226 HIS A N   1 
ATOM   1504 C  CA  . HIS A 1 226 ? 164.601 148.527 109.563 1.00 52.86 ? 226 HIS A CA  1 
ATOM   1505 C  C   . HIS A 1 226 ? 164.913 149.921 110.104 1.00 52.86 ? 226 HIS A C   1 
ATOM   1506 O  O   . HIS A 1 226 ? 166.033 150.184 110.545 1.00 52.86 ? 226 HIS A O   1 
ATOM   1507 C  CB  . HIS A 1 226 ? 165.246 147.449 110.413 1.00 52.86 ? 226 HIS A CB  1 
ATOM   1508 C  CG  . HIS A 1 226 ? 165.156 146.065 109.846 1.00 52.86 ? 226 HIS A CG  1 
ATOM   1509 N  ND1 . HIS A 1 226 ? 166.127 145.539 109.020 1.00 52.86 ? 226 HIS A ND1 1 
ATOM   1510 C  CD2 . HIS A 1 226 ? 164.246 145.080 110.023 1.00 52.86 ? 226 HIS A CD2 1 
ATOM   1511 C  CE1 . HIS A 1 226 ? 165.810 144.298 108.698 1.00 52.86 ? 226 HIS A CE1 1 
ATOM   1512 N  NE2 . HIS A 1 226 ? 164.672 143.995 109.291 1.00 52.86 ? 226 HIS A NE2 1 
ATOM   1513 N  N   . SER A 1 227 ? 163.927 150.818 110.050 1.00 51.00 ? 227 SER A N   1 
ATOM   1514 C  CA  . SER A 1 227 ? 164.043 152.191 110.552 1.00 51.00 ? 227 SER A CA  1 
ATOM   1515 C  C   . SER A 1 227 ? 162.891 152.448 111.520 1.00 51.00 ? 227 SER A C   1 
ATOM   1516 O  O   . SER A 1 227 ? 161.843 152.954 111.119 1.00 51.00 ? 227 SER A O   1 
ATOM   1517 C  CB  . SER A 1 227 ? 164.020 153.164 109.413 1.00 51.00 ? 227 SER A CB  1 
ATOM   1518 O  OG  . SER A 1 227 ? 162.770 153.103 108.758 1.00 51.00 ? 227 SER A OG  1 
ATOM   1519 N  N   . GLY A 1 228 ? 163.086 152.105 112.790 1.00 45.49 ? 228 GLY A N   1 
ATOM   1520 C  CA  . GLY A 1 228 ? 161.977 151.935 113.694 1.00 45.49 ? 228 GLY A CA  1 
ATOM   1521 C  C   . GLY A 1 228 ? 161.266 153.194 114.141 1.00 45.49 ? 228 GLY A C   1 
ATOM   1522 O  O   . GLY A 1 228 ? 160.174 153.501 113.661 1.00 45.49 ? 228 GLY A O   1 
ATOM   1523 N  N   . PRO A 1 229 ? 161.870 153.967 115.048 1.00 47.93 ? 229 PRO A N   1 
ATOM   1524 C  CA  . PRO A 1 229 ? 161.183 155.148 115.589 1.00 47.93 ? 229 PRO A CA  1 
ATOM   1525 C  C   . PRO A 1 229 ? 161.301 156.333 114.646 1.00 47.93 ? 229 PRO A C   1 
ATOM   1526 O  O   . PRO A 1 229 ? 162.389 156.872 114.426 1.00 47.93 ? 229 PRO A O   1 
ATOM   1527 C  CB  . PRO A 1 229 ? 161.910 155.390 116.918 1.00 47.93 ? 229 PRO A CB  1 
ATOM   1528 C  CG  . PRO A 1 229 ? 163.248 154.819 116.731 1.00 47.93 ? 229 PRO A CG  1 
ATOM   1529 C  CD  . PRO A 1 229 ? 163.077 153.638 115.822 1.00 47.93 ? 229 PRO A CD  1 
ATOM   1530 N  N   . THR A 1 230 ? 160.173 156.744 114.082 1.00 47.56 ? 230 THR A N   1 
ATOM   1531 C  CA  . THR A 1 230 ? 160.212 157.744 113.026 1.00 47.56 ? 230 THR A CA  1 
ATOM   1532 C  C   . THR A 1 230 ? 159.237 158.893 113.227 1.00 47.56 ? 230 THR A C   1 
ATOM   1533 O  O   . THR A 1 230 ? 159.450 159.971 112.662 1.00 47.56 ? 230 THR A O   1 
ATOM   1534 C  CB  . THR A 1 230 ? 159.972 157.065 111.669 1.00 47.56 ? 230 THR A CB  1 
ATOM   1535 O  OG1 . THR A 1 230 ? 160.057 158.038 110.623 1.00 47.56 ? 230 THR A OG1 1 
ATOM   1536 C  CG2 . THR A 1 230 ? 158.624 156.365 111.631 1.00 47.56 ? 230 THR A CG2 1 
ATOM   1537 N  N   . LYS A 1 231 ? 158.175 158.713 114.008 1.00 43.47 ? 231 LYS A N   1 
ATOM   1538 C  CA  . LYS A 1 231 ? 157.162 159.748 114.182 1.00 43.47 ? 231 LYS A CA  1 
ATOM   1539 C  C   . LYS A 1 231 ? 156.770 159.903 115.649 1.00 43.47 ? 231 LYS A C   1 
ATOM   1540 O  O   . LYS A 1 231 ? 157.415 159.377 116.554 1.00 43.47 ? 231 LYS A O   1 
ATOM   1541 C  CB  . LYS A 1 231 ? 155.919 159.444 113.347 1.00 43.47 ? 231 LYS A CB  1 
ATOM   1542 C  CG  . LYS A 1 231 ? 156.095 159.513 111.852 1.00 43.47 ? 231 LYS A CG  1 
ATOM   1543 C  CD  . LYS A 1 231 ? 156.321 160.931 111.413 1.00 43.47 ? 231 LYS A CD  1 
ATOM   1544 C  CE  . LYS A 1 231 ? 156.282 161.048 109.909 1.00 43.47 ? 231 LYS A CE  1 
ATOM   1545 N  NZ  . LYS A 1 231 ? 157.447 160.397 109.264 1.00 43.47 ? 231 LYS A NZ  1 
ATOM   1546 N  N   . LEU A 1 232 ? 155.718 160.690 115.869 1.00 42.48 ? 232 LEU A N   1 
ATOM   1547 C  CA  . LEU A 1 232 ? 154.965 160.698 117.111 1.00 42.48 ? 232 LEU A CA  1 
ATOM   1548 C  C   . LEU A 1 232 ? 153.490 160.411 116.915 1.00 42.48 ? 232 LEU A C   1 
ATOM   1549 O  O   . LEU A 1 232 ? 152.740 160.455 117.891 1.00 42.48 ? 232 LEU A O   1 
ATOM   1550 C  CB  . LEU A 1 232 ? 155.098 162.038 117.839 1.00 42.48 ? 232 LEU A CB  1 
ATOM   1551 C  CG  . LEU A 1 232 ? 156.433 162.285 118.528 1.00 42.48 ? 232 LEU A CG  1 
ATOM   1552 C  CD1 . LEU A 1 232 ? 156.491 163.685 119.102 1.00 42.48 ? 232 LEU A CD1 1 
ATOM   1553 C  CD2 . LEU A 1 232 ? 156.622 161.264 119.615 1.00 42.48 ? 232 LEU A CD2 1 
ATOM   1554 N  N   . VAL A 1 233 ? 153.047 160.173 115.685 1.00 40.17 ? 233 VAL A N   1 
ATOM   1555 C  CA  . VAL A 1 233 ? 151.749 159.548 115.493 1.00 40.17 ? 233 VAL A CA  1 
ATOM   1556 C  C   . VAL A 1 233 ? 151.918 158.043 115.429 1.00 40.17 ? 233 VAL A C   1 
ATOM   1557 O  O   . VAL A 1 233 ? 151.227 157.293 116.119 1.00 40.17 ? 233 VAL A O   1 
ATOM   1558 C  CB  . VAL A 1 233 ? 151.056 160.078 114.228 1.00 40.17 ? 233 VAL A CB  1 
ATOM   1559 C  CG1 . VAL A 1 233 ? 149.721 159.399 114.061 1.00 40.17 ? 233 VAL A CG1 1 
ATOM   1560 C  CG2 . VAL A 1 233 ? 150.880 161.575 114.293 1.00 40.17 ? 233 VAL A CG2 1 
ATOM   1561 N  N   . LEU A 1 234 ? 152.858 157.580 114.612 1.00 39.29 ? 234 LEU A N   1 
ATOM   1562 C  CA  . LEU A 1 234 ? 153.042 156.151 114.437 1.00 39.29 ? 234 LEU A CA  1 
ATOM   1563 C  C   . LEU A 1 234 ? 153.656 155.471 115.646 1.00 39.29 ? 234 LEU A C   1 
ATOM   1564 O  O   . LEU A 1 234 ? 153.445 154.270 115.814 1.00 39.29 ? 234 LEU A O   1 
ATOM   1565 C  CB  . LEU A 1 234 ? 153.915 155.877 113.220 1.00 39.29 ? 234 LEU A CB  1 
ATOM   1566 C  CG  . LEU A 1 234 ? 153.318 156.143 111.851 1.00 39.29 ? 234 LEU A CG  1 
ATOM   1567 C  CD1 . LEU A 1 234 ? 154.405 155.990 110.837 1.00 39.29 ? 234 LEU A CD1 1 
ATOM   1568 C  CD2 . LEU A 1 234 ? 152.210 155.162 111.572 1.00 39.29 ? 234 LEU A CD2 1 
ATOM   1569 N  N   . TYR A 1 235 ? 154.395 156.187 116.489 1.00 39.53 ? 235 TYR A N   1 
ATOM   1570 C  CA  . TYR A 1 235 ? 155.081 155.514 117.583 1.00 39.53 ? 235 TYR A CA  1 
ATOM   1571 C  C   . TYR A 1 235 ? 154.120 155.101 118.687 1.00 39.53 ? 235 TYR A C   1 
ATOM   1572 O  O   . TYR A 1 235 ? 154.416 154.174 119.442 1.00 39.53 ? 235 TYR A O   1 
ATOM   1573 C  CB  . TYR A 1 235 ? 156.178 156.409 118.151 1.00 39.53 ? 235 TYR A CB  1 
ATOM   1574 C  CG  . TYR A 1 235 ? 157.060 155.706 119.142 1.00 39.53 ? 235 TYR A CG  1 
ATOM   1575 C  CD1 . TYR A 1 235 ? 158.048 154.843 118.715 1.00 39.53 ? 235 TYR A CD1 1 
ATOM   1576 C  CD2 . TYR A 1 235 ? 156.891 155.881 120.501 1.00 39.53 ? 235 TYR A CD2 1 
ATOM   1577 C  CE1 . TYR A 1 235 ? 158.850 154.180 119.613 1.00 39.53 ? 235 TYR A CE1 1 
ATOM   1578 C  CE2 . TYR A 1 235 ? 157.682 155.216 121.404 1.00 39.53 ? 235 TYR A CE2 1 
ATOM   1579 C  CZ  . TYR A 1 235 ? 158.658 154.368 120.950 1.00 39.53 ? 235 TYR A CZ  1 
ATOM   1580 O  OH  . TYR A 1 235 ? 159.461 153.708 121.838 1.00 39.53 ? 235 TYR A OH  1 
ATOM   1581 N  N   . PHE A 1 236 ? 152.965 155.747 118.786 1.00 37.48 ? 236 PHE A N   1 
ATOM   1582 C  CA  . PHE A 1 236 ? 152.015 155.462 119.846 1.00 37.48 ? 236 PHE A CA  1 
ATOM   1583 C  C   . PHE A 1 236 ? 150.837 154.618 119.400 1.00 37.48 ? 236 PHE A C   1 
ATOM   1584 O  O   . PHE A 1 236 ? 150.178 154.017 120.244 1.00 37.48 ? 236 PHE A O   1 
ATOM   1585 C  CB  . PHE A 1 236 ? 151.496 156.756 120.448 1.00 37.48 ? 236 PHE A CB  1 
ATOM   1586 C  CG  . PHE A 1 236 ? 152.506 157.499 121.232 1.00 37.48 ? 236 PHE A CG  1 
ATOM   1587 C  CD1 . PHE A 1 236 ? 152.833 157.098 122.506 1.00 37.48 ? 236 PHE A CD1 1 
ATOM   1588 C  CD2 . PHE A 1 236 ? 153.088 158.629 120.722 1.00 37.48 ? 236 PHE A CD2 1 
ATOM   1589 C  CE1 . PHE A 1 236 ? 153.755 157.787 123.243 1.00 37.48 ? 236 PHE A CE1 1 
ATOM   1590 C  CE2 . PHE A 1 236 ? 154.008 159.328 121.450 1.00 37.48 ? 236 PHE A CE2 1 
ATOM   1591 C  CZ  . PHE A 1 236 ? 154.342 158.907 122.715 1.00 37.48 ? 236 PHE A CZ  1 
ATOM   1592 N  N   . THR A 1 237 ? 150.544 154.544 118.112 1.00 39.71 ? 237 THR A N   1 
ATOM   1593 C  CA  . THR A 1 237 ? 149.485 153.650 117.675 1.00 39.71 ? 237 THR A CA  1 
ATOM   1594 C  C   . THR A 1 237 ? 149.929 152.209 117.658 1.00 39.71 ? 237 THR A C   1 
ATOM   1595 O  O   . THR A 1 237 ? 149.082 151.314 117.594 1.00 39.71 ? 237 THR A O   1 
ATOM   1596 C  CB  . THR A 1 237 ? 148.986 154.024 116.291 1.00 39.71 ? 237 THR A CB  1 
ATOM   1597 O  OG1 . THR A 1 237 ? 150.045 153.874 115.348 1.00 39.71 ? 237 THR A OG1 1 
ATOM   1598 C  CG2 . THR A 1 237 ? 148.575 155.422 116.297 1.00 39.71 ? 237 THR A CG2 1 
ATOM   1599 N  N   . GLY A 1 238 ? 151.233 151.969 117.695 1.00 38.69 ? 238 GLY A N   1 
ATOM   1600 C  CA  . GLY A 1 238 ? 151.760 150.637 117.847 1.00 38.69 ? 238 GLY A CA  1 
ATOM   1601 C  C   . GLY A 1 238 ? 152.199 150.414 119.270 1.00 38.69 ? 238 GLY A C   1 
ATOM   1602 O  O   . GLY A 1 238 ? 152.748 149.358 119.585 1.00 38.69 ? 238 GLY A O   1 
ATOM   1603 N  N   . ALA A 1 239 ? 151.980 151.400 120.140 1.00 35.80 ? 239 ALA A N   1 
ATOM   1604 C  CA  . ALA A 1 239 ? 152.326 151.273 121.546 1.00 35.80 ? 239 ALA A CA  1 
ATOM   1605 C  C   . ALA A 1 239 ? 151.133 150.992 122.437 1.00 35.80 ? 239 ALA A C   1 
ATOM   1606 O  O   . ALA A 1 239 ? 151.317 150.433 123.514 1.00 35.80 ? 239 ALA A O   1 
ATOM   1607 C  CB  . ALA A 1 239 ? 153.033 152.533 122.048 1.00 35.80 ? 239 ALA A CB  1 
ATOM   1608 N  N   . THR A 1 240 ? 149.926 151.379 122.037 1.00 38.52 ? 240 THR A N   1 
ATOM   1609 C  CA  . THR A 1 240 ? 148.718 150.961 122.731 1.00 38.52 ? 240 THR A CA  1 
ATOM   1610 C  C   . THR A 1 240 ? 148.195 149.644 122.190 1.00 38.52 ? 240 THR A C   1 
ATOM   1611 O  O   . THR A 1 240 ? 147.219 149.106 122.714 1.00 38.52 ? 240 THR A O   1 
ATOM   1612 C  CB  . THR A 1 240 ? 147.627 152.020 122.632 1.00 38.52 ? 240 THR A CB  1 
ATOM   1613 O  OG1 . THR A 1 240 ? 147.228 152.160 121.268 1.00 38.52 ? 240 THR A OG1 1 
ATOM   1614 C  CG2 . THR A 1 240 ? 148.142 153.333 123.127 1.00 38.52 ? 240 THR A CG2 1 
ATOM   1615 N  N   . ASN A 1 241 ? 148.821 149.112 121.148 1.00 39.42 ? 241 ASN A N   1 
ATOM   1616 C  CA  . ASN A 1 241 ? 148.517 147.773 120.679 1.00 39.42 ? 241 ASN A CA  1 
ATOM   1617 C  C   . ASN A 1 241 ? 149.196 146.718 121.533 1.00 39.42 ? 241 ASN A C   1 
ATOM   1618 O  O   . ASN A 1 241 ? 148.906 145.529 121.394 1.00 39.42 ? 241 ASN A O   1 
ATOM   1619 C  CB  . ASN A 1 241 ? 148.957 147.623 119.226 1.00 39.42 ? 241 ASN A CB  1 
ATOM   1620 C  CG  . ASN A 1 241 ? 148.234 146.530 118.514 1.00 39.42 ? 241 ASN A CG  1 
ATOM   1621 O  OD1 . ASN A 1 241 ? 147.327 145.911 119.056 1.00 39.42 ? 241 ASN A OD1 1 
ATOM   1622 N  ND2 . ASN A 1 241 ? 148.625 146.282 117.279 1.00 39.42 ? 241 ASN A ND2 1 
ATOM   1623 N  N   . ILE A 1 242 ? 150.113 147.144 122.402 1.00 40.23 ? 242 ILE A N   1 
ATOM   1624 C  CA  . ILE A 1 242 ? 150.696 146.267 123.405 1.00 40.23 ? 242 ILE A CA  1 
ATOM   1625 C  C   . ILE A 1 242 ? 149.949 146.412 124.726 1.00 40.23 ? 242 ILE A C   1 
ATOM   1626 O  O   . ILE A 1 242 ? 149.752 145.431 125.449 1.00 40.23 ? 242 ILE A O   1 
ATOM   1627 C  CB  . ILE A 1 242 ? 152.196 146.585 123.516 1.00 40.23 ? 242 ILE A CB  1 
ATOM   1628 C  CG1 . ILE A 1 242 ? 152.870 146.279 122.187 1.00 40.23 ? 242 ILE A CG1 1 
ATOM   1629 C  CG2 . ILE A 1 242 ? 152.861 145.811 124.611 1.00 40.23 ? 242 ILE A CG2 1 
ATOM   1630 C  CD1 . ILE A 1 242 ? 154.240 146.807 122.093 1.00 40.23 ? 242 ILE A CD1 1 
ATOM   1631 N  N   . LEU A 1 243 ? 149.486 147.624 125.046 1.00 41.02 ? 243 LEU A N   1 
ATOM   1632 C  CA  . LEU A 1 243 ? 148.624 147.854 126.201 1.00 41.02 ? 243 LEU A CA  1 
ATOM   1633 C  C   . LEU A 1 243 ? 147.262 147.208 126.041 1.00 41.02 ? 243 LEU A C   1 
ATOM   1634 O  O   . LEU A 1 243 ? 146.633 146.873 127.044 1.00 41.02 ? 243 LEU A O   1 
ATOM   1635 C  CB  . LEU A 1 243 ? 148.460 149.359 126.436 1.00 41.02 ? 243 LEU A CB  1 
ATOM   1636 C  CG  . LEU A 1 243 ? 147.760 149.986 127.643 1.00 41.02 ? 243 LEU A CG  1 
ATOM   1637 C  CD1 . LEU A 1 243 ? 148.443 151.282 127.982 1.00 41.02 ? 243 LEU A CD1 1 
ATOM   1638 C  CD2 . LEU A 1 243 ? 146.323 150.282 127.351 1.00 41.02 ? 243 LEU A CD2 1 
ATOM   1639 N  N   . TYR A 1 244 ? 146.787 147.046 124.811 1.00 40.45 ? 244 TYR A N   1 
ATOM   1640 C  CA  . TYR A 1 244 ? 145.577 146.278 124.566 1.00 40.45 ? 244 TYR A CA  1 
ATOM   1641 C  C   . TYR A 1 244 ? 145.762 144.805 124.886 1.00 40.45 ? 244 TYR A C   1 
ATOM   1642 O  O   . TYR A 1 244 ? 144.803 144.147 125.293 1.00 40.45 ? 244 TYR A O   1 
ATOM   1643 C  CB  . TYR A 1 244 ? 145.160 146.460 123.113 1.00 40.45 ? 244 TYR A CB  1 
ATOM   1644 C  CG  . TYR A 1 244 ? 143.977 145.649 122.660 1.00 40.45 ? 244 TYR A CG  1 
ATOM   1645 C  CD1 . TYR A 1 244 ? 142.691 146.016 122.995 1.00 40.45 ? 244 TYR A CD1 1 
ATOM   1646 C  CD2 . TYR A 1 244 ? 144.151 144.529 121.866 1.00 40.45 ? 244 TYR A CD2 1 
ATOM   1647 C  CE1 . TYR A 1 244 ? 141.611 145.281 122.562 1.00 40.45 ? 244 TYR A CE1 1 
ATOM   1648 C  CE2 . TYR A 1 244 ? 143.084 143.796 121.434 1.00 40.45 ? 244 TYR A CE2 1 
ATOM   1649 C  CZ  . TYR A 1 244 ? 141.818 144.173 121.792 1.00 40.45 ? 244 TYR A CZ  1 
ATOM   1650 O  OH  . TYR A 1 244 ? 140.745 143.444 121.361 1.00 40.45 ? 244 TYR A OH  1 
ATOM   1651 N  N   . THR A 1 245 ? 146.978 144.282 124.746 1.00 42.84 ? 245 THR A N   1 
ATOM   1652 C  CA  . THR A 1 245 ? 147.198 142.844 124.860 1.00 42.84 ? 245 THR A CA  1 
ATOM   1653 C  C   . THR A 1 245 ? 147.185 142.367 126.309 1.00 42.84 ? 245 THR A C   1 
ATOM   1654 O  O   . THR A 1 245 ? 146.414 141.475 126.670 1.00 42.84 ? 245 THR A O   1 
ATOM   1655 C  CB  . THR A 1 245 ? 148.519 142.466 124.199 1.00 42.84 ? 245 THR A CB  1 
ATOM   1656 O  OG1 . THR A 1 245 ? 148.480 142.831 122.821 1.00 42.84 ? 245 THR A OG1 1 
ATOM   1657 C  CG2 . THR A 1 245 ? 148.738 140.991 124.300 1.00 42.84 ? 245 THR A CG2 1 
ATOM   1658 N  N   . PHE A 1 246 ? 148.029 142.949 127.152 1.00 42.89 ? 246 PHE A N   1 
ATOM   1659 C  CA  . PHE A 1 246 ? 148.279 142.412 128.480 1.00 42.89 ? 246 PHE A CA  1 
ATOM   1660 C  C   . PHE A 1 246 ? 147.349 143.013 129.520 1.00 42.89 ? 246 PHE A C   1 
ATOM   1661 O  O   . PHE A 1 246 ? 147.028 144.201 129.483 1.00 42.89 ? 246 PHE A O   1 
ATOM   1662 C  CB  . PHE A 1 246 ? 149.733 142.653 128.871 1.00 42.89 ? 246 PHE A CB  1 
ATOM   1663 C  CG  . PHE A 1 246 ? 150.697 141.846 128.072 1.00 42.89 ? 246 PHE A CG  1 
ATOM   1664 C  CD1 . PHE A 1 246 ? 150.962 140.533 128.406 1.00 42.89 ? 246 PHE A CD1 1 
ATOM   1665 C  CD2 . PHE A 1 246 ? 151.308 142.384 126.961 1.00 42.89 ? 246 PHE A CD2 1 
ATOM   1666 C  CE1 . PHE A 1 246 ? 151.838 139.783 127.657 1.00 42.89 ? 246 PHE A CE1 1 
ATOM   1667 C  CE2 . PHE A 1 246 ? 152.175 141.639 126.212 1.00 42.89 ? 246 PHE A CE2 1 
ATOM   1668 C  CZ  . PHE A 1 246 ? 152.445 140.339 126.561 1.00 42.89 ? 246 PHE A CZ  1 
ATOM   1669 N  N   . GLY A 1 247 ? 146.921 142.179 130.450 1.00 47.38 ? 247 GLY A N   1 
ATOM   1670 C  CA  . GLY A 1 247 ? 146.105 142.605 131.570 1.00 47.38 ? 247 GLY A CA  1 
ATOM   1671 C  C   . GLY A 1 247 ? 144.999 141.610 131.849 1.00 47.38 ? 247 GLY A C   1 
ATOM   1672 O  O   . GLY A 1 247 ? 144.771 140.665 131.098 1.00 47.38 ? 247 GLY A O   1 
ATOM   1673 N  N   . GLY A 1 248 ? 144.301 141.824 132.964 1.00 54.42 ? 248 GLY A N   1 
ATOM   1674 C  CA  . GLY A 1 248 ? 143.202 140.955 133.345 1.00 54.42 ? 248 GLY A CA  1 
ATOM   1675 C  C   . GLY A 1 248 ? 141.844 141.458 132.894 1.00 54.42 ? 248 GLY A C   1 
ATOM   1676 O  O   . GLY A 1 248 ? 141.399 142.520 133.331 1.00 54.42 ? 248 GLY A O   1 
ATOM   1677 N  N   . HIS A 1 249 ? 141.147 140.683 132.061 1.00 57.60 ? 249 HIS A N   1 
ATOM   1678 C  CA  . HIS A 1 249 ? 139.972 141.164 131.345 1.00 57.60 ? 249 HIS A CA  1 
ATOM   1679 C  C   . HIS A 1 249 ? 138.676 140.989 132.122 1.00 57.60 ? 249 HIS A C   1 
ATOM   1680 O  O   . HIS A 1 249 ? 137.627 140.764 131.503 1.00 57.60 ? 249 HIS A O   1 
ATOM   1681 C  CB  . HIS A 1 249 ? 139.856 140.468 129.991 1.00 57.60 ? 249 HIS A CB  1 
ATOM   1682 C  CG  . HIS A 1 249 ? 140.955 140.804 129.038 1.00 57.60 ? 249 HIS A CG  1 
ATOM   1683 N  ND1 . HIS A 1 249 ? 141.092 142.052 128.474 1.00 57.60 ? 249 HIS A ND1 1 
ATOM   1684 C  CD2 . HIS A 1 249 ? 141.944 140.044 128.514 1.00 57.60 ? 249 HIS A CD2 1 
ATOM   1685 C  CE1 . HIS A 1 249 ? 142.132 142.055 127.661 1.00 57.60 ? 249 HIS A CE1 1 
ATOM   1686 N  NE2 . HIS A 1 249 ? 142.666 140.848 127.666 1.00 57.60 ? 249 HIS A NE2 1 
ATOM   1687 N  N   . ALA A 1 250 ? 138.736 141.030 133.456 1.00 59.62 ? 250 ALA A N   1 
ATOM   1688 C  CA  . ALA A 1 250 ? 137.592 141.048 134.375 1.00 59.62 ? 250 ALA A CA  1 
ATOM   1689 C  C   . ALA A 1 250 ? 136.756 139.773 134.335 1.00 59.62 ? 250 ALA A C   1 
ATOM   1690 O  O   . ALA A 1 250 ? 135.627 139.759 134.828 1.00 59.62 ? 250 ALA A O   1 
ATOM   1691 C  CB  . ALA A 1 250 ? 136.692 142.272 134.155 1.00 59.62 ? 250 ALA A CB  1 
ATOM   1692 N  N   . VAL A 1 251 ? 137.277 138.693 133.765 1.00 59.97 ? 251 VAL A N   1 
ATOM   1693 C  CA  . VAL A 1 251 ? 136.782 137.362 134.069 1.00 59.97 ? 251 VAL A CA  1 
ATOM   1694 C  C   . VAL A 1 251 ? 137.771 136.625 134.958 1.00 59.97 ? 251 VAL A C   1 
ATOM   1695 O  O   . VAL A 1 251 ? 137.659 135.423 135.149 1.00 59.97 ? 251 VAL A O   1 
ATOM   1696 C  CB  . VAL A 1 251 ? 136.461 136.549 132.808 1.00 59.97 ? 251 VAL A CB  1 
ATOM   1697 C  CG1 . VAL A 1 251 ? 135.344 137.198 132.039 1.00 59.97 ? 251 VAL A CG1 1 
ATOM   1698 C  CG2 . VAL A 1 251 ? 137.693 136.399 131.955 1.00 59.97 ? 251 VAL A CG2 1 
ATOM   1699 N  N   . THR A 1 252 ? 138.741 137.344 135.505 1.00 59.08 ? 252 THR A N   1 
ATOM   1700 C  CA  . THR A 1 252 ? 139.622 136.768 136.498 1.00 59.08 ? 252 THR A CA  1 
ATOM   1701 C  C   . THR A 1 252 ? 138.979 136.690 137.871 1.00 59.08 ? 252 THR A C   1 
ATOM   1702 O  O   . THR A 1 252 ? 139.622 136.210 138.805 1.00 59.08 ? 252 THR A O   1 
ATOM   1703 C  CB  . THR A 1 252 ? 140.925 137.562 136.592 1.00 59.08 ? 252 THR A CB  1 
ATOM   1704 O  OG1 . THR A 1 252 ? 140.639 138.911 136.960 1.00 59.08 ? 252 THR A OG1 1 
ATOM   1705 C  CG2 . THR A 1 252 ? 141.643 137.563 135.271 1.00 59.08 ? 252 THR A CG2 1 
ATOM   1706 N  N   . VAL A 1 253 ? 137.757 137.197 138.038 1.00 57.98 ? 253 VAL A N   1 
ATOM   1707 C  CA  . VAL A 1 253 ? 136.987 136.874 139.233 1.00 57.98 ? 253 VAL A CA  1 
ATOM   1708 C  C   . VAL A 1 253 ? 136.276 135.543 139.052 1.00 57.98 ? 253 VAL A C   1 
ATOM   1709 O  O   . VAL A 1 253 ? 136.306 134.678 139.934 1.00 57.98 ? 253 VAL A O   1 
ATOM   1710 C  CB  . VAL A 1 253 ? 135.995 137.996 139.554 1.00 57.98 ? 253 VAL A CB  1 
ATOM   1711 C  CG1 . VAL A 1 253 ? 135.148 137.608 140.728 1.00 57.98 ? 253 VAL A CG1 1 
ATOM   1712 C  CG2 . VAL A 1 253 ? 136.725 139.238 139.863 1.00 57.98 ? 253 VAL A CG2 1 
ATOM   1713 N  N   . GLU A 1 254 ? 135.664 135.340 137.888 1.00 61.46 ? 254 GLU A N   1 
ATOM   1714 C  CA  . GLU A 1 254 ? 134.977 134.099 137.559 1.00 61.46 ? 254 GLU A CA  1 
ATOM   1715 C  C   . GLU A 1 254 ? 135.913 132.915 137.383 1.00 61.46 ? 254 GLU A C   1 
ATOM   1716 O  O   . GLU A 1 254 ? 135.435 131.781 137.316 1.00 61.46 ? 254 GLU A O   1 
ATOM   1717 C  CB  . GLU A 1 254 ? 134.147 134.284 136.297 1.00 61.46 ? 254 GLU A CB  1 
ATOM   1718 C  CG  . GLU A 1 254 ? 132.906 135.084 136.541 1.00 61.46 ? 254 GLU A CG  1 
ATOM   1719 C  CD  . GLU A 1 254 ? 132.153 135.397 135.279 1.00 61.46 ? 254 GLU A CD  1 
ATOM   1720 O  OE1 . GLU A 1 254 ? 132.739 135.253 134.195 1.00 61.46 ? 254 GLU A OE1 1 
ATOM   1721 O  OE2 . GLU A 1 254 ? 130.966 135.765 135.363 1.00 61.46 ? 254 GLU A OE2 1 
ATOM   1722 N  N   . ILE A 1 255 ? 137.219 133.140 137.288 1.00 58.76 ? 255 ILE A N   1 
ATOM   1723 C  CA  . ILE A 1 255 ? 138.161 132.036 137.366 1.00 58.76 ? 255 ILE A CA  1 
ATOM   1724 C  C   . ILE A 1 255 ? 138.549 131.784 138.813 1.00 58.76 ? 255 ILE A C   1 
ATOM   1725 O  O   . ILE A 1 255 ? 138.711 130.632 139.224 1.00 58.76 ? 255 ILE A O   1 
ATOM   1726 C  CB  . ILE A 1 255 ? 139.369 132.328 136.458 1.00 58.76 ? 255 ILE A CB  1 
ATOM   1727 C  CG1 . ILE A 1 255 ? 138.911 132.358 135.003 1.00 58.76 ? 255 ILE A CG1 1 
ATOM   1728 C  CG2 . ILE A 1 255 ? 140.462 131.311 136.606 1.00 58.76 ? 255 ILE A CG2 1 
ATOM   1729 C  CD1 . ILE A 1 255 ? 139.904 132.979 134.071 1.00 58.76 ? 255 ILE A CD1 1 
ATOM   1730 N  N   . MET A 1 256 ? 138.639 132.841 139.628 1.00 58.07 ? 256 MET A N   1 
ATOM   1731 C  CA  . MET A 1 256 ? 138.964 132.650 141.039 1.00 58.07 ? 256 MET A CA  1 
ATOM   1732 C  C   . MET A 1 256 ? 137.832 131.987 141.797 1.00 58.07 ? 256 MET A C   1 
ATOM   1733 O  O   . MET A 1 256 ? 138.072 131.271 142.772 1.00 58.07 ? 256 MET A O   1 
ATOM   1734 C  CB  . MET A 1 256 ? 139.290 133.969 141.723 1.00 58.07 ? 256 MET A CB  1 
ATOM   1735 C  CG  . MET A 1 256 ? 140.628 134.534 141.446 1.00 58.07 ? 256 MET A CG  1 
ATOM   1736 S  SD  . MET A 1 256 ? 140.769 136.022 142.423 1.00 58.07 ? 256 MET A SD  1 
ATOM   1737 C  CE  . MET A 1 256 ? 140.870 135.309 144.056 1.00 58.07 ? 256 MET A CE  1 
ATOM   1738 N  N   . HIS A 1 257 ? 136.598 132.231 141.388 1.00 62.95 ? 257 HIS A N   1 
ATOM   1739 C  CA  . HIS A 1 257 ? 135.486 131.705 142.150 1.00 62.95 ? 257 HIS A CA  1 
ATOM   1740 C  C   . HIS A 1 257 ? 135.338 130.201 141.994 1.00 62.95 ? 257 HIS A C   1 
ATOM   1741 O  O   . HIS A 1 257 ? 134.807 129.552 142.898 1.00 62.95 ? 257 HIS A O   1 
ATOM   1742 C  CB  . HIS A 1 257 ? 134.203 132.414 141.732 1.00 62.95 ? 257 HIS A CB  1 
ATOM   1743 C  CG  . HIS A 1 257 ? 133.015 132.034 142.549 1.00 62.95 ? 257 HIS A CG  1 
ATOM   1744 N  ND1 . HIS A 1 257 ? 132.813 132.502 143.827 1.00 62.95 ? 257 HIS A ND1 1 
ATOM   1745 C  CD2 . HIS A 1 257 ? 131.980 131.207 142.280 1.00 62.95 ? 257 HIS A CD2 1 
ATOM   1746 C  CE1 . HIS A 1 257 ? 131.695 131.991 144.306 1.00 62.95 ? 257 HIS A CE1 1 
ATOM   1747 N  NE2 . HIS A 1 257 ? 131.171 131.200 143.387 1.00 62.95 ? 257 HIS A NE2 1 
ATOM   1748 N  N   . ALA A 1 258 ? 135.841 129.630 140.908 1.00 64.19 ? 258 ALA A N   1 
ATOM   1749 C  CA  . ALA A 1 258 ? 135.651 128.222 140.599 1.00 64.19 ? 258 ALA A CA  1 
ATOM   1750 C  C   . ALA A 1 258 ? 136.944 127.429 140.730 1.00 64.19 ? 258 ALA A C   1 
ATOM   1751 O  O   . ALA A 1 258 ? 137.261 126.591 139.888 1.00 64.19 ? 258 ALA A O   1 
ATOM   1752 C  CB  . ALA A 1 258 ? 135.067 128.058 139.205 1.00 64.19 ? 258 ALA A CB  1 
ATOM   1753 N  N   . MET A 1 259 ? 137.711 127.693 141.780 1.00 64.34 ? 259 MET A N   1 
ATOM   1754 C  CA  . MET A 1 259 ? 138.905 126.928 142.105 1.00 64.34 ? 259 MET A CA  1 
ATOM   1755 C  C   . MET A 1 259 ? 138.707 126.276 143.466 1.00 64.34 ? 259 MET A C   1 
ATOM   1756 O  O   . MET A 1 259 ? 137.774 126.613 144.195 1.00 64.34 ? 259 MET A O   1 
ATOM   1757 C  CB  . MET A 1 259 ? 140.151 127.826 142.129 1.00 64.34 ? 259 MET A CB  1 
ATOM   1758 C  CG  . MET A 1 259 ? 140.593 128.376 140.784 1.00 64.34 ? 259 MET A CG  1 
ATOM   1759 S  SD  . MET A 1 259 ? 141.872 129.632 140.943 1.00 64.34 ? 259 MET A SD  1 
ATOM   1760 C  CE  . MET A 1 259 ? 143.221 128.656 141.571 1.00 64.34 ? 259 MET A CE  1 
ATOM   1761 N  N   . TRP A 1 260 ? 139.567 125.313 143.799 1.00 69.07 ? 260 TRP A N   1 
ATOM   1762 C  CA  . TRP A 1 260 ? 139.612 124.842 145.177 1.00 69.07 ? 260 TRP A CA  1 
ATOM   1763 C  C   . TRP A 1 260 ? 140.295 125.823 146.101 1.00 69.07 ? 260 TRP A C   1 
ATOM   1764 O  O   . TRP A 1 260 ? 139.791 126.093 147.194 1.00 69.07 ? 260 TRP A O   1 
ATOM   1765 C  CB  . TRP A 1 260 ? 140.361 123.515 145.306 1.00 69.07 ? 260 TRP A CB  1 
ATOM   1766 C  CG  . TRP A 1 260 ? 139.565 122.312 145.008 1.00 69.07 ? 260 TRP A CG  1 
ATOM   1767 C  CD1 . TRP A 1 260 ? 138.246 122.261 144.692 1.00 69.07 ? 260 TRP A CD1 1 
ATOM   1768 C  CD2 . TRP A 1 260 ? 140.022 120.959 145.056 1.00 69.07 ? 260 TRP A CD2 1 
ATOM   1769 N  NE1 . TRP A 1 260 ? 137.855 120.958 144.507 1.00 69.07 ? 260 TRP A NE1 1 
ATOM   1770 C  CE2 . TRP A 1 260 ? 138.929 120.138 144.731 1.00 69.07 ? 260 TRP A CE2 1 
ATOM   1771 C  CE3 . TRP A 1 260 ? 141.256 120.363 145.327 1.00 69.07 ? 260 TRP A CE3 1 
ATOM   1772 C  CZ2 . TRP A 1 260 ? 139.031 118.752 144.670 1.00 69.07 ? 260 TRP A CZ2 1 
ATOM   1773 C  CZ3 . TRP A 1 260 ? 141.355 118.986 145.267 1.00 69.07 ? 260 TRP A CZ3 1 
ATOM   1774 C  CH2 . TRP A 1 260 ? 140.251 118.197 144.942 1.00 69.07 ? 260 TRP A CH2 1 
ATOM   1775 N  N   . LYS A 1 261 ? 141.417 126.375 145.670 1.00 66.39 ? 261 LYS A N   1 
ATOM   1776 C  CA  . LYS A 1 261 ? 142.394 126.977 146.566 1.00 66.39 ? 261 LYS A CA  1 
ATOM   1777 C  C   . LYS A 1 261 ? 142.751 128.339 145.991 1.00 66.39 ? 261 LYS A C   1 
ATOM   1778 O  O   . LYS A 1 261 ? 143.802 128.503 145.359 1.00 66.39 ? 261 LYS A O   1 
ATOM   1779 C  CB  . LYS A 1 261 ? 143.584 126.031 146.696 1.00 66.39 ? 261 LYS A CB  1 
ATOM   1780 C  CG  . LYS A 1 261 ? 144.660 126.358 147.680 1.00 66.39 ? 261 LYS A CG  1 
ATOM   1781 C  CD  . LYS A 1 261 ? 145.464 125.087 147.883 1.00 66.39 ? 261 LYS A CD  1 
ATOM   1782 C  CE  . LYS A 1 261 ? 146.154 124.641 146.599 1.00 66.39 ? 261 LYS A CE  1 
ATOM   1783 N  NZ  . LYS A 1 261 ? 147.015 123.442 146.781 1.00 66.39 ? 261 LYS A NZ  1 
ATOM   1784 N  N   . PRO A 1 262 ? 141.885 129.343 146.170 1.00 63.51 ? 262 PRO A N   1 
ATOM   1785 C  CA  . PRO A 1 262 ? 142.032 130.571 145.382 1.00 63.51 ? 262 PRO A CA  1 
ATOM   1786 C  C   . PRO A 1 262 ? 143.076 131.530 145.909 1.00 63.51 ? 262 PRO A C   1 
ATOM   1787 O  O   . PRO A 1 262 ? 143.152 132.653 145.402 1.00 63.51 ? 262 PRO A O   1 
ATOM   1788 C  CB  . PRO A 1 262 ? 140.633 131.195 145.442 1.00 63.51 ? 262 PRO A CB  1 
ATOM   1789 C  CG  . PRO A 1 262 ? 139.736 130.104 145.879 1.00 63.51 ? 262 PRO A CG  1 
ATOM   1790 C  CD  . PRO A 1 262 ? 140.567 129.304 146.817 1.00 63.51 ? 262 PRO A CD  1 
ATOM   1791 N  N   . GLN A 1 263 ? 143.862 131.158 146.911 1.00 63.85 ? 263 GLN A N   1 
ATOM   1792 C  CA  . GLN A 1 263 ? 145.004 131.987 147.264 1.00 63.85 ? 263 GLN A CA  1 
ATOM   1793 C  C   . GLN A 1 263 ? 146.253 131.615 146.478 1.00 63.85 ? 263 GLN A C   1 
ATOM   1794 O  O   . GLN A 1 263 ? 147.304 132.221 146.691 1.00 63.85 ? 263 GLN A O   1 
ATOM   1795 C  CB  . GLN A 1 263 ? 145.284 131.915 148.767 1.00 63.85 ? 263 GLN A CB  1 
ATOM   1796 C  CG  . GLN A 1 263 ? 145.801 130.585 149.267 1.00 63.85 ? 263 GLN A CG  1 
ATOM   1797 C  CD  . GLN A 1 263 ? 144.691 129.636 149.678 1.00 63.85 ? 263 GLN A CD  1 
ATOM   1798 O  OE1 . GLN A 1 263 ? 143.521 129.851 149.360 1.00 63.85 ? 263 GLN A OE1 1 
ATOM   1799 N  NE2 . GLN A 1 263 ? 145.055 128.572 150.386 1.00 63.85 ? 263 GLN A NE2 1 
ATOM   1800 N  N   . LYS A 1 264 ? 146.165 130.636 145.582 1.00 62.19 ? 264 LYS A N   1 
ATOM   1801 C  CA  . LYS A 1 264 ? 147.256 130.315 144.673 1.00 62.19 ? 264 LYS A CA  1 
ATOM   1802 C  C   . LYS A 1 264 ? 147.167 131.091 143.373 1.00 62.19 ? 264 LYS A C   1 
ATOM   1803 O  O   . LYS A 1 264 ? 148.083 131.001 142.554 1.00 62.19 ? 264 LYS A O   1 
ATOM   1804 C  CB  . LYS A 1 264 ? 147.260 128.823 144.344 1.00 62.19 ? 264 LYS A CB  1 
ATOM   1805 C  CG  . LYS A 1 264 ? 147.376 127.926 145.547 1.00 62.19 ? 264 LYS A CG  1 
ATOM   1806 C  CD  . LYS A 1 264 ? 148.719 128.015 146.230 1.00 62.19 ? 264 LYS A CD  1 
ATOM   1807 C  CE  . LYS A 1 264 ? 149.795 127.321 145.421 1.00 62.19 ? 264 LYS A CE  1 
ATOM   1808 N  NZ  . LYS A 1 264 ? 151.099 127.306 146.137 1.00 62.19 ? 264 LYS A NZ  1 
ATOM   1809 N  N   . PHE A 1 265 ? 146.087 131.845 143.168 1.00 59.27 ? 265 PHE A N   1 
ATOM   1810 C  CA  . PHE A 1 265 ? 145.876 132.529 141.900 1.00 59.27 ? 265 PHE A CA  1 
ATOM   1811 C  C   . PHE A 1 265 ? 146.821 133.708 141.741 1.00 59.27 ? 265 PHE A C   1 
ATOM   1812 O  O   . PHE A 1 265 ? 147.070 134.156 140.620 1.00 59.27 ? 265 PHE A O   1 
ATOM   1813 C  CB  . PHE A 1 265 ? 144.425 132.984 141.803 1.00 59.27 ? 265 PHE A CB  1 
ATOM   1814 C  CG  . PHE A 1 265 ? 144.054 133.548 140.476 1.00 59.27 ? 265 PHE A CG  1 
ATOM   1815 C  CD1 . PHE A 1 265 ? 143.785 132.717 139.420 1.00 59.27 ? 265 PHE A CD1 1 
ATOM   1816 C  CD2 . PHE A 1 265 ? 143.986 134.915 140.284 1.00 59.27 ? 265 PHE A CD2 1 
ATOM   1817 C  CE1 . PHE A 1 265 ? 143.436 133.233 138.200 1.00 59.27 ? 265 PHE A CE1 1 
ATOM   1818 C  CE2 . PHE A 1 265 ? 143.645 135.435 139.069 1.00 59.27 ? 265 PHE A CE2 1 
ATOM   1819 C  CZ  . PHE A 1 265 ? 143.369 134.594 138.027 1.00 59.27 ? 265 PHE A CZ  1 
ATOM   1820 N  N   . LYS A 1 266 ? 147.380 134.196 142.843 1.00 62.08 ? 266 LYS A N   1 
ATOM   1821 C  CA  . LYS A 1 266 ? 148.345 135.284 142.782 1.00 62.08 ? 266 LYS A CA  1 
ATOM   1822 C  C   . LYS A 1 266 ? 149.646 134.843 142.120 1.00 62.08 ? 266 LYS A C   1 
ATOM   1823 O  O   . LYS A 1 266 ? 150.431 135.684 141.671 1.00 62.08 ? 266 LYS A O   1 
ATOM   1824 C  CB  . LYS A 1 266 ? 148.602 135.777 144.200 1.00 62.08 ? 266 LYS A CB  1 
ATOM   1825 C  CG  . LYS A 1 266 ? 147.344 136.254 144.897 1.00 62.08 ? 266 LYS A CG  1 
ATOM   1826 C  CD  . LYS A 1 266 ? 147.603 136.609 146.350 1.00 62.08 ? 266 LYS A CD  1 
ATOM   1827 C  CE  . LYS A 1 266 ? 147.292 135.465 147.285 1.00 62.08 ? 266 LYS A CE  1 
ATOM   1828 N  NZ  . LYS A 1 266 ? 148.346 134.417 147.261 1.00 62.08 ? 266 LYS A NZ  1 
ATOM   1829 N  N   . TYR A 1 267 ? 149.893 133.534 142.074 1.00 65.22 ? 267 TYR A N   1 
ATOM   1830 C  CA  . TYR A 1 267 ? 151.059 132.916 141.457 1.00 65.22 ? 267 TYR A CA  1 
ATOM   1831 C  C   . TYR A 1 267 ? 150.742 132.251 140.124 1.00 65.22 ? 267 TYR A C   1 
ATOM   1832 O  O   . TYR A 1 267 ? 151.626 132.150 139.274 1.00 65.22 ? 267 TYR A O   1 
ATOM   1833 C  CB  . TYR A 1 267 ? 151.659 131.880 142.424 1.00 65.22 ? 267 TYR A CB  1 
ATOM   1834 C  CG  . TYR A 1 267 ? 152.860 131.114 141.910 1.00 65.22 ? 267 TYR A CG  1 
ATOM   1835 C  CD1 . TYR A 1 267 ? 154.125 131.687 141.897 1.00 65.22 ? 267 TYR A CD1 1 
ATOM   1836 C  CD2 . TYR A 1 267 ? 152.726 129.811 141.434 1.00 65.22 ? 267 TYR A CD2 1 
ATOM   1837 C  CE1 . TYR A 1 267 ? 155.226 130.984 141.422 1.00 65.22 ? 267 TYR A CE1 1 
ATOM   1838 C  CE2 . TYR A 1 267 ? 153.818 129.104 140.954 1.00 65.22 ? 267 TYR A CE2 1 
ATOM   1839 C  CZ  . TYR A 1 267 ? 155.062 129.695 140.953 1.00 65.22 ? 267 TYR A CZ  1 
ATOM   1840 O  OH  . TYR A 1 267 ? 156.147 128.995 140.481 1.00 65.22 ? 267 TYR A OH  1 
ATOM   1841 N  N   . ILE A 1 268 ? 149.503 131.803 139.920 1.00 57.86 ? 268 ILE A N   1 
ATOM   1842 C  CA  . ILE A 1 268 ? 149.134 131.130 138.677 1.00 57.86 ? 268 ILE A CA  1 
ATOM   1843 C  C   . ILE A 1 268 ? 149.009 132.135 137.540 1.00 57.86 ? 268 ILE A C   1 
ATOM   1844 O  O   . ILE A 1 268 ? 149.354 131.840 136.390 1.00 57.86 ? 268 ILE A O   1 
ATOM   1845 C  CB  . ILE A 1 268 ? 147.842 130.321 138.897 1.00 57.86 ? 268 ILE A CB  1 
ATOM   1846 C  CG1 . ILE A 1 268 ? 148.124 129.157 139.834 1.00 57.86 ? 268 ILE A CG1 1 
ATOM   1847 C  CG2 . ILE A 1 268 ? 147.231 129.798 137.611 1.00 57.86 ? 268 ILE A CG2 1 
ATOM   1848 C  CD1 . ILE A 1 268 ? 146.880 128.501 140.332 1.00 57.86 ? 268 ILE A CD1 1 
ATOM   1849 N  N   . TYR A 1 269 ? 148.564 133.352 137.844 1.00 52.28 ? 269 TYR A N   1 
ATOM   1850 C  CA  . TYR A 1 269 ? 148.396 134.335 136.787 1.00 52.28 ? 269 TYR A CA  1 
ATOM   1851 C  C   . TYR A 1 269 ? 149.736 134.867 136.297 1.00 52.28 ? 269 TYR A C   1 
ATOM   1852 O  O   . TYR A 1 269 ? 149.853 135.276 135.140 1.00 52.28 ? 269 TYR A O   1 
ATOM   1853 C  CB  . TYR A 1 269 ? 147.515 135.479 137.264 1.00 52.28 ? 269 TYR A CB  1 
ATOM   1854 C  CG  . TYR A 1 269 ? 147.100 136.351 136.123 1.00 52.28 ? 269 TYR A CG  1 
ATOM   1855 C  CD1 . TYR A 1 269 ? 146.114 135.936 135.248 1.00 52.28 ? 269 TYR A CD1 1 
ATOM   1856 C  CD2 . TYR A 1 269 ? 147.711 137.568 135.892 1.00 52.28 ? 269 TYR A CD2 1 
ATOM   1857 C  CE1 . TYR A 1 269 ? 145.741 136.706 134.194 1.00 52.28 ? 269 TYR A CE1 1 
ATOM   1858 C  CE2 . TYR A 1 269 ? 147.346 138.344 134.832 1.00 52.28 ? 269 TYR A CE2 1 
ATOM   1859 C  CZ  . TYR A 1 269 ? 146.354 137.911 134.001 1.00 52.28 ? 269 TYR A CZ  1 
ATOM   1860 O  OH  . TYR A 1 269 ? 145.986 138.690 132.937 1.00 52.28 ? 269 TYR A OH  1 
ATOM   1861 N  N   . LEU A 1 270 ? 150.754 134.857 137.151 1.00 51.83 ? 270 LEU A N   1 
ATOM   1862 C  CA  . LEU A 1 270 ? 152.106 135.158 136.703 1.00 51.83 ? 270 LEU A CA  1 
ATOM   1863 C  C   . LEU A 1 270 ? 152.638 134.070 135.786 1.00 51.83 ? 270 LEU A C   1 
ATOM   1864 O  O   . LEU A 1 270 ? 153.473 134.337 134.921 1.00 51.83 ? 270 LEU A O   1 
ATOM   1865 C  CB  . LEU A 1 270 ? 153.014 135.304 137.913 1.00 51.83 ? 270 LEU A CB  1 
ATOM   1866 C  CG  . LEU A 1 270 ? 154.443 135.770 137.715 1.00 51.83 ? 270 LEU A CG  1 
ATOM   1867 C  CD1 . LEU A 1 270 ? 154.454 137.220 137.282 1.00 51.83 ? 270 LEU A CD1 1 
ATOM   1868 C  CD2 . LEU A 1 270 ? 155.226 135.568 138.993 1.00 51.83 ? 270 LEU A CD2 1 
ATOM   1869 N  N   . MET A 1 271 ? 152.157 132.842 135.957 1.00 55.27 ? 271 MET A N   1 
ATOM   1870 C  CA  . MET A 1 271 ? 152.645 131.732 135.155 1.00 55.27 ? 271 MET A CA  1 
ATOM   1871 C  C   . MET A 1 271 ? 151.893 131.628 133.836 1.00 55.27 ? 271 MET A C   1 
ATOM   1872 O  O   . MET A 1 271 ? 152.425 131.087 132.865 1.00 55.27 ? 271 MET A O   1 
ATOM   1873 C  CB  . MET A 1 271 ? 152.520 130.439 135.950 1.00 55.27 ? 271 MET A CB  1 
ATOM   1874 C  CG  . MET A 1 271 ? 153.385 129.329 135.453 1.00 55.27 ? 271 MET A CG  1 
ATOM   1875 S  SD  . MET A 1 271 ? 155.091 129.861 135.627 1.00 55.27 ? 271 MET A SD  1 
ATOM   1876 C  CE  . MET A 1 271 ? 155.213 129.959 137.410 1.00 55.27 ? 271 MET A CE  1 
ATOM   1877 N  N   . ALA A 1 272 ? 150.653 132.117 133.777 1.00 49.62 ? 272 ALA A N   1 
ATOM   1878 C  CA  . ALA A 1 272 ? 149.943 132.162 132.502 1.00 49.62 ? 272 ALA A CA  1 
ATOM   1879 C  C   . ALA A 1 272 ? 150.383 133.347 131.657 1.00 49.62 ? 272 ALA A C   1 
ATOM   1880 O  O   . ALA A 1 272 ? 150.161 133.354 130.445 1.00 49.62 ? 272 ALA A O   1 
ATOM   1881 C  CB  . ALA A 1 272 ? 148.437 132.209 132.735 1.00 49.62 ? 272 ALA A CB  1 
ATOM   1882 N  N   . THR A 1 273 ? 150.985 134.361 132.279 1.00 46.89 ? 273 THR A N   1 
ATOM   1883 C  CA  . THR A 1 273 ? 151.539 135.489 131.535 1.00 46.89 ? 273 THR A CA  1 
ATOM   1884 C  C   . THR A 1 273 ? 152.855 135.124 130.866 1.00 46.89 ? 273 THR A C   1 
ATOM   1885 O  O   . THR A 1 273 ? 153.039 135.377 129.671 1.00 46.89 ? 273 THR A O   1 
ATOM   1886 C  CB  . THR A 1 273 ? 151.732 136.679 132.473 1.00 46.89 ? 273 THR A CB  1 
ATOM   1887 O  OG1 . THR A 1 273 ? 150.457 137.167 132.899 1.00 46.89 ? 273 THR A OG1 1 
ATOM   1888 C  CG2 . THR A 1 273 ? 152.485 137.788 131.806 1.00 46.89 ? 273 THR A CG2 1 
ATOM   1889 N  N   . LEU A 1 274 ? 153.767 134.487 131.606 1.00 44.82 ? 274 LEU A N   1 
ATOM   1890 C  CA  . LEU A 1 274 ? 155.104 134.213 131.094 1.00 44.82 ? 274 LEU A CA  1 
ATOM   1891 C  C   . LEU A 1 274 ? 155.128 133.129 130.028 1.00 44.82 ? 274 LEU A C   1 
ATOM   1892 O  O   . LEU A 1 274 ? 156.185 132.891 129.445 1.00 44.82 ? 274 LEU A O   1 
ATOM   1893 C  CB  . LEU A 1 274 ? 156.041 133.816 132.233 1.00 44.82 ? 274 LEU A CB  1 
ATOM   1894 C  CG  . LEU A 1 274 ? 156.421 134.830 133.313 1.00 44.82 ? 274 LEU A CG  1 
ATOM   1895 C  CD1 . LEU A 1 274 ? 157.249 134.150 134.374 1.00 44.82 ? 274 LEU A CD1 1 
ATOM   1896 C  CD2 . LEU A 1 274 ? 157.192 135.991 132.741 1.00 44.82 ? 274 LEU A CD2 1 
ATOM   1897 N  N   . TYR A 1 275 ? 154.016 132.447 129.782 1.00 44.81 ? 275 TYR A N   1 
ATOM   1898 C  CA  . TYR A 1 275 ? 153.942 131.583 128.615 1.00 44.81 ? 275 TYR A CA  1 
ATOM   1899 C  C   . TYR A 1 275 ? 153.643 132.369 127.351 1.00 44.81 ? 275 TYR A C   1 
ATOM   1900 O  O   . TYR A 1 275 ? 154.118 131.999 126.273 1.00 44.81 ? 275 TYR A O   1 
ATOM   1901 C  CB  . TYR A 1 275 ? 152.874 130.513 128.802 1.00 44.81 ? 275 TYR A CB  1 
ATOM   1902 C  CG  . TYR A 1 275 ? 152.816 129.527 127.667 1.00 44.81 ? 275 TYR A CG  1 
ATOM   1903 C  CD1 . TYR A 1 275 ? 153.806 128.576 127.517 1.00 44.81 ? 275 TYR A CD1 1 
ATOM   1904 C  CD2 . TYR A 1 275 ? 151.776 129.536 126.756 1.00 44.81 ? 275 TYR A CD2 1 
ATOM   1905 C  CE1 . TYR A 1 275 ? 153.772 127.666 126.489 1.00 44.81 ? 275 TYR A CE1 1 
ATOM   1906 C  CE2 . TYR A 1 275 ? 151.734 128.623 125.724 1.00 44.81 ? 275 TYR A CE2 1 
ATOM   1907 C  CZ  . TYR A 1 275 ? 152.739 127.693 125.598 1.00 44.81 ? 275 TYR A CZ  1 
ATOM   1908 O  OH  . TYR A 1 275 ? 152.721 126.779 124.580 1.00 44.81 ? 275 TYR A OH  1 
ATOM   1909 N  N   . VAL A 1 276 ? 152.865 133.449 127.461 1.00 44.14 ? 276 VAL A N   1 
ATOM   1910 C  CA  . VAL A 1 276 ? 152.494 134.243 126.296 1.00 44.14 ? 276 VAL A CA  1 
ATOM   1911 C  C   . VAL A 1 276 ? 153.693 135.025 125.758 1.00 44.14 ? 276 VAL A C   1 
ATOM   1912 O  O   . VAL A 1 276 ? 153.757 135.303 124.554 1.00 44.14 ? 276 VAL A O   1 
ATOM   1913 C  CB  . VAL A 1 276 ? 151.279 135.117 126.682 1.00 44.14 ? 276 VAL A CB  1 
ATOM   1914 C  CG1 . VAL A 1 276 ? 150.857 136.059 125.587 1.00 44.14 ? 276 VAL A CG1 1 
ATOM   1915 C  CG2 . VAL A 1 276 ? 150.111 134.229 127.011 1.00 44.14 ? 276 VAL A CG2 1 
ATOM   1916 N  N   . PHE A 1 277 ? 154.688 135.317 126.606 1.00 44.55 ? 277 PHE A N   1 
ATOM   1917 C  CA  . PHE A 1 277 ? 155.964 135.829 126.112 1.00 44.55 ? 277 PHE A CA  1 
ATOM   1918 C  C   . PHE A 1 277 ? 156.660 134.851 125.177 1.00 44.55 ? 277 PHE A C   1 
ATOM   1919 O  O   . PHE A 1 277 ? 157.402 135.287 124.296 1.00 44.55 ? 277 PHE A O   1 
ATOM   1920 C  CB  . PHE A 1 277 ? 156.936 136.144 127.246 1.00 44.55 ? 277 PHE A CB  1 
ATOM   1921 C  CG  . PHE A 1 277 ? 156.602 137.367 128.046 1.00 44.55 ? 277 PHE A CG  1 
ATOM   1922 C  CD1 . PHE A 1 277 ? 155.614 138.246 127.660 1.00 44.55 ? 277 PHE A CD1 1 
ATOM   1923 C  CD2 . PHE A 1 277 ? 157.332 137.650 129.182 1.00 44.55 ? 277 PHE A CD2 1 
ATOM   1924 C  CE1 . PHE A 1 277 ? 155.344 139.357 128.421 1.00 44.55 ? 277 PHE A CE1 1 
ATOM   1925 C  CE2 . PHE A 1 277 ? 157.069 138.756 129.934 1.00 44.55 ? 277 PHE A CE2 1 
ATOM   1926 C  CZ  . PHE A 1 277 ? 156.079 139.612 129.556 1.00 44.55 ? 277 PHE A CZ  1 
ATOM   1927 N  N   . THR A 1 278 ? 156.443 133.547 125.342 1.00 44.28 ? 278 THR A N   1 
ATOM   1928 C  CA  . THR A 1 278 ? 156.946 132.565 124.392 1.00 44.28 ? 278 THR A CA  1 
ATOM   1929 C  C   . THR A 1 278 ? 156.001 132.334 123.223 1.00 44.28 ? 278 THR A C   1 
ATOM   1930 O  O   . THR A 1 278 ? 156.222 131.402 122.447 1.00 44.28 ? 278 THR A O   1 
ATOM   1931 C  CB  . THR A 1 278 ? 157.217 131.230 125.080 1.00 44.28 ? 278 THR A CB  1 
ATOM   1932 O  OG1 . THR A 1 278 ? 155.987 130.686 125.554 1.00 44.28 ? 278 THR A OG1 1 
ATOM   1933 C  CG2 . THR A 1 278 ? 158.155 131.424 126.244 1.00 44.28 ? 278 THR A CG2 1 
ATOM   1934 N  N   . LEU A 1 279 ? 154.944 133.136 123.093 1.00 45.36 ? 279 LEU A N   1 
ATOM   1935 C  CA  . LEU A 1 279 ? 154.133 133.155 121.882 1.00 45.36 ? 279 LEU A CA  1 
ATOM   1936 C  C   . LEU A 1 279 ? 154.252 134.454 121.102 1.00 45.36 ? 279 LEU A C   1 
ATOM   1937 O  O   . LEU A 1 279 ? 153.987 134.460 119.899 1.00 45.36 ? 279 LEU A O   1 
ATOM   1938 C  CB  . LEU A 1 279 ? 152.652 132.930 122.200 1.00 45.36 ? 279 LEU A CB  1 
ATOM   1939 C  CG  . LEU A 1 279 ? 152.169 131.615 122.802 1.00 45.36 ? 279 LEU A CG  1 
ATOM   1940 C  CD1 . LEU A 1 279 ? 150.678 131.684 123.045 1.00 45.36 ? 279 LEU A CD1 1 
ATOM   1941 C  CD2 . LEU A 1 279 ? 152.505 130.440 121.931 1.00 45.36 ? 279 LEU A CD2 1 
ATOM   1942 N  N   . THR A 1 280 ? 154.632 135.558 121.741 1.00 44.41 ? 280 THR A N   1 
ATOM   1943 C  CA  . THR A 1 280 ? 154.556 136.860 121.097 1.00 44.41 ? 280 THR A CA  1 
ATOM   1944 C  C   . THR A 1 280 ? 155.916 137.437 120.732 1.00 44.41 ? 280 THR A C   1 
ATOM   1945 O  O   . THR A 1 280 ? 156.073 137.936 119.617 1.00 44.41 ? 280 THR A O   1 
ATOM   1946 C  CB  . THR A 1 280 ? 153.798 137.844 121.981 1.00 44.41 ? 280 THR A CB  1 
ATOM   1947 O  OG1 . THR A 1 280 ? 154.487 137.999 123.221 1.00 44.41 ? 280 THR A OG1 1 
ATOM   1948 C  CG2 . THR A 1 280 ? 152.394 137.366 122.250 1.00 44.41 ? 280 THR A CG2 1 
ATOM   1949 N  N   . ILE A 1 281 ? 156.905 137.403 121.634 1.00 41.70 ? 281 ILE A N   1 
ATOM   1950 C  CA  . ILE A 1 281 ? 158.206 138.023 121.334 1.00 41.70 ? 281 ILE A CA  1 
ATOM   1951 C  C   . ILE A 1 281 ? 159.018 137.255 120.293 1.00 41.70 ? 281 ILE A C   1 
ATOM   1952 O  O   . ILE A 1 281 ? 159.567 137.900 119.389 1.00 41.70 ? 281 ILE A O   1 
ATOM   1953 C  CB  . ILE A 1 281 ? 158.972 138.306 122.634 1.00 41.70 ? 281 ILE A CB  1 
ATOM   1954 C  CG1 . ILE A 1 281 ? 158.240 139.345 123.470 1.00 41.70 ? 281 ILE A CG1 1 
ATOM   1955 C  CG2 . ILE A 1 281 ? 160.369 138.790 122.367 1.00 41.70 ? 281 ILE A CG2 1 
ATOM   1956 C  CD1 . ILE A 1 281 ? 158.799 139.506 124.854 1.00 41.70 ? 281 ILE A CD1 1 
ATOM   1957 N  N   . PRO A 1 282 ? 159.123 135.912 120.314 1.00 42.17 ? 282 PRO A N   1 
ATOM   1958 C  CA  . PRO A 1 282 ? 159.779 135.254 119.174 1.00 42.17 ? 282 PRO A CA  1 
ATOM   1959 C  C   . PRO A 1 282 ? 158.977 135.282 117.889 1.00 42.17 ? 282 PRO A C   1 
ATOM   1960 O  O   . PRO A 1 282 ? 159.571 135.176 116.811 1.00 42.17 ? 282 PRO A O   1 
ATOM   1961 C  CB  . PRO A 1 282 ? 159.977 133.816 119.664 1.00 42.17 ? 282 PRO A CB  1 
ATOM   1962 C  CG  . PRO A 1 282 ? 159.979 133.907 121.088 1.00 42.17 ? 282 PRO A CG  1 
ATOM   1963 C  CD  . PRO A 1 282 ? 158.979 134.940 121.414 1.00 42.17 ? 282 PRO A CD  1 
ATOM   1964 N  N   . SER A 1 283 ? 157.657 135.410 117.955 1.00 42.19 ? 283 SER A N   1 
ATOM   1965 C  CA  . SER A 1 283 ? 156.867 135.570 116.744 1.00 42.19 ? 283 SER A CA  1 
ATOM   1966 C  C   . SER A 1 283 ? 157.107 136.912 116.070 1.00 42.19 ? 283 SER A C   1 
ATOM   1967 O  O   . SER A 1 283 ? 157.335 136.971 114.860 1.00 42.19 ? 283 SER A O   1 
ATOM   1968 C  CB  . SER A 1 283 ? 155.380 135.434 117.065 1.00 42.19 ? 283 SER A CB  1 
ATOM   1969 O  OG  . SER A 1 283 ? 154.608 135.743 115.924 1.00 42.19 ? 283 SER A OG  1 
ATOM   1970 N  N   . ALA A 1 284 ? 157.069 137.996 116.841 1.00 40.53 ? 284 ALA A N   1 
ATOM   1971 C  CA  . ALA A 1 284 ? 157.051 139.318 116.237 1.00 40.53 ? 284 ALA A CA  1 
ATOM   1972 C  C   . ALA A 1 284 ? 158.452 139.827 115.943 1.00 40.53 ? 284 ALA A C   1 
ATOM   1973 O  O   . ALA A 1 284 ? 158.617 140.779 115.179 1.00 40.53 ? 284 ALA A O   1 
ATOM   1974 C  CB  . ALA A 1 284 ? 156.300 140.283 117.153 1.00 40.53 ? 284 ALA A CB  1 
ATOM   1975 N  N   . ALA A 1 285 ? 159.473 139.216 116.536 1.00 39.61 ? 285 ALA A N   1 
ATOM   1976 C  CA  . ALA A 1 285 ? 160.836 139.547 116.150 1.00 39.61 ? 285 ALA A CA  1 
ATOM   1977 C  C   . ALA A 1 285 ? 161.353 138.661 115.032 1.00 39.61 ? 285 ALA A C   1 
ATOM   1978 O  O   . ALA A 1 285 ? 162.493 138.837 114.600 1.00 39.61 ? 285 ALA A O   1 
ATOM   1979 C  CB  . ALA A 1 285 ? 161.768 139.454 117.350 1.00 39.61 ? 285 ALA A CB  1 
ATOM   1980 N  N   . ALA A 1 286 ? 160.550 137.713 114.562 1.00 42.93 ? 286 ALA A N   1 
ATOM   1981 C  CA  . ALA A 1 286 ? 160.900 136.921 113.395 1.00 42.93 ? 286 ALA A CA  1 
ATOM   1982 C  C   . ALA A 1 286 ? 160.212 137.409 112.134 1.00 42.93 ? 286 ALA A C   1 
ATOM   1983 O  O   . ALA A 1 286 ? 160.789 137.308 111.049 1.00 42.93 ? 286 ALA A O   1 
ATOM   1984 C  CB  . ALA A 1 286 ? 160.556 135.454 113.626 1.00 42.93 ? 286 ALA A CB  1 
ATOM   1985 N  N   . VAL A 1 287 ? 158.991 137.927 112.240 1.00 43.92 ? 287 VAL A N   1 
ATOM   1986 C  CA  . VAL A 1 287 ? 158.357 138.492 111.058 1.00 43.92 ? 287 VAL A CA  1 
ATOM   1987 C  C   . VAL A 1 287 ? 158.926 139.866 110.759 1.00 43.92 ? 287 VAL A C   1 
ATOM   1988 O  O   . VAL A 1 287 ? 159.181 140.191 109.598 1.00 43.92 ? 287 VAL A O   1 
ATOM   1989 C  CB  . VAL A 1 287 ? 156.835 138.557 111.225 1.00 43.92 ? 287 VAL A CB  1 
ATOM   1990 C  CG1 . VAL A 1 287 ? 156.176 138.948 109.928 1.00 43.92 ? 287 VAL A CG1 1 
ATOM   1991 C  CG2 . VAL A 1 287 ? 156.313 137.259 111.707 1.00 43.92 ? 287 VAL A CG2 1 
ATOM   1992 N  N   . TYR A 1 288 ? 159.139 140.693 111.780 1.00 45.44 ? 288 TYR A N   1 
ATOM   1993 C  CA  . TYR A 1 288 ? 159.710 142.013 111.559 1.00 45.44 ? 288 TYR A CA  1 
ATOM   1994 C  C   . TYR A 1 288 ? 161.156 141.964 111.082 1.00 45.44 ? 288 TYR A C   1 
ATOM   1995 O  O   . TYR A 1 288 ? 161.558 142.841 110.312 1.00 45.44 ? 288 TYR A O   1 
ATOM   1996 C  CB  . TYR A 1 288 ? 159.608 142.849 112.830 1.00 45.44 ? 288 TYR A CB  1 
ATOM   1997 C  CG  . TYR A 1 288 ? 160.392 144.127 112.751 1.00 45.44 ? 288 TYR A CG  1 
ATOM   1998 C  CD1 . TYR A 1 288 ? 160.000 145.151 111.911 1.00 45.44 ? 288 TYR A CD1 1 
ATOM   1999 C  CD2 . TYR A 1 288 ? 161.530 144.300 113.504 1.00 45.44 ? 288 TYR A CD2 1 
ATOM   2000 C  CE1 . TYR A 1 288 ? 160.722 146.308 111.826 1.00 45.44 ? 288 TYR A CE1 1 
ATOM   2001 C  CE2 . TYR A 1 288 ? 162.254 145.445 113.429 1.00 45.44 ? 288 TYR A CE2 1 
ATOM   2002 C  CZ  . TYR A 1 288 ? 161.849 146.448 112.591 1.00 45.44 ? 288 TYR A CZ  1 
ATOM   2003 O  OH  . TYR A 1 288 ? 162.589 147.598 112.522 1.00 45.44 ? 288 TYR A OH  1 
ATOM   2004 N  N   . TRP A 1 289 ? 161.932 140.960 111.503 1.00 48.12 ? 289 TRP A N   1 
ATOM   2005 C  CA  . TRP A 1 289 ? 163.319 140.830 111.066 1.00 48.12 ? 289 TRP A CA  1 
ATOM   2006 C  C   . TRP A 1 289 ? 163.425 140.650 109.566 1.00 48.12 ? 289 TRP A C   1 
ATOM   2007 O  O   . TRP A 1 289 ? 164.163 141.386 108.905 1.00 48.12 ? 289 TRP A O   1 
ATOM   2008 C  CB  . TRP A 1 289 ? 163.969 139.637 111.745 1.00 48.12 ? 289 TRP A CB  1 
ATOM   2009 C  CG  . TRP A 1 289 ? 165.344 139.352 111.263 1.00 48.12 ? 289 TRP A CG  1 
ATOM   2010 C  CD1 . TRP A 1 289 ? 166.465 140.068 111.519 1.00 48.12 ? 289 TRP A CD1 1 
ATOM   2011 C  CD2 . TRP A 1 289 ? 165.741 138.279 110.412 1.00 48.12 ? 289 TRP A CD2 1 
ATOM   2012 N  NE1 . TRP A 1 289 ? 167.544 139.499 110.900 1.00 48.12 ? 289 TRP A NE1 1 
ATOM   2013 C  CE2 . TRP A 1 289 ? 167.122 138.399 110.207 1.00 48.12 ? 289 TRP A CE2 1 
ATOM   2014 C  CE3 . TRP A 1 289 ? 165.063 137.220 109.813 1.00 48.12 ? 289 TRP A CE3 1 
ATOM   2015 C  CZ2 . TRP A 1 289 ? 167.835 137.503 109.433 1.00 48.12 ? 289 TRP A CZ2 1 
ATOM   2016 C  CZ3 . TRP A 1 289 ? 165.775 136.333 109.038 1.00 48.12 ? 289 TRP A CZ3 1 
ATOM   2017 C  CH2 . TRP A 1 289 ? 167.143 136.480 108.854 1.00 48.12 ? 289 TRP A CH2 1 
ATOM   2018 N  N   . ALA A 1 290 ? 162.662 139.716 109.016 1.00 48.74 ? 290 ALA A N   1 
ATOM   2019 C  CA  . ALA A 1 290 ? 162.723 139.375 107.608 1.00 48.74 ? 290 ALA A CA  1 
ATOM   2020 C  C   . ALA A 1 290 ? 162.136 140.453 106.711 1.00 48.74 ? 290 ALA A C   1 
ATOM   2021 O  O   . ALA A 1 290 ? 162.569 140.599 105.565 1.00 48.74 ? 290 ALA A O   1 
ATOM   2022 C  CB  . ALA A 1 290 ? 161.988 138.060 107.373 1.00 48.74 ? 290 ALA A CB  1 
ATOM   2023 N  N   . PHE A 1 291 ? 161.173 141.222 107.201 1.00 47.48 ? 291 PHE A N   1 
ATOM   2024 C  CA  . PHE A 1 291 ? 160.409 142.102 106.332 1.00 47.48 ? 291 PHE A CA  1 
ATOM   2025 C  C   . PHE A 1 291 ? 160.612 143.585 106.576 1.00 47.48 ? 291 PHE A C   1 
ATOM   2026 O  O   . PHE A 1 291 ? 160.609 144.347 105.612 1.00 47.48 ? 291 PHE A O   1 
ATOM   2027 C  CB  . PHE A 1 291 ? 158.925 141.756 106.426 1.00 47.48 ? 291 PHE A CB  1 
ATOM   2028 C  CG  . PHE A 1 291 ? 158.603 140.446 105.809 1.00 47.48 ? 291 PHE A CG  1 
ATOM   2029 C  CD1 . PHE A 1 291 ? 158.482 140.332 104.446 1.00 47.48 ? 291 PHE A CD1 1 
ATOM   2030 C  CD2 . PHE A 1 291 ? 158.476 139.319 106.583 1.00 47.48 ? 291 PHE A CD2 1 
ATOM   2031 C  CE1 . PHE A 1 291 ? 158.213 139.121 103.869 1.00 47.48 ? 291 PHE A CE1 1 
ATOM   2032 C  CE2 . PHE A 1 291 ? 158.205 138.097 106.009 1.00 47.48 ? 291 PHE A CE2 1 
ATOM   2033 C  CZ  . PHE A 1 291 ? 158.073 137.998 104.655 1.00 47.48 ? 291 PHE A CZ  1 
ATOM   2034 N  N   . GLY A 1 292 ? 160.790 144.021 107.804 1.00 48.29 ? 292 GLY A N   1 
ATOM   2035 C  CA  . GLY A 1 292 ? 161.278 145.372 107.991 1.00 48.29 ? 292 GLY A CA  1 
ATOM   2036 C  C   . GLY A 1 292 ? 160.177 146.398 107.854 1.00 48.29 ? 292 GLY A C   1 
ATOM   2037 O  O   . GLY A 1 292 ? 159.107 146.253 108.446 1.00 48.29 ? 292 GLY A O   1 
ATOM   2038 N  N   . ASP A 1 293 ? 160.421 147.450 107.065 1.00 50.61 ? 293 ASP A N   1 
ATOM   2039 C  CA  . ASP A 1 293 ? 159.457 148.538 106.932 1.00 50.61 ? 293 ASP A CA  1 
ATOM   2040 C  C   . ASP A 1 293 ? 158.456 148.314 105.830 1.00 50.61 ? 293 ASP A C   1 
ATOM   2041 O  O   . ASP A 1 293 ? 157.818 149.268 105.387 1.00 50.61 ? 293 ASP A O   1 
ATOM   2042 C  CB  . ASP A 1 293 ? 160.162 149.877 106.713 1.00 50.61 ? 293 ASP A CB  1 
ATOM   2043 C  CG  . ASP A 1 293 ? 160.818 150.410 107.975 1.00 50.61 ? 293 ASP A CG  1 
ATOM   2044 O  OD1 . ASP A 1 293 ? 160.380 150.031 109.080 1.00 50.61 ? 293 ASP A OD1 1 
ATOM   2045 O  OD2 . ASP A 1 293 ? 161.754 151.231 107.865 1.00 50.61 ? 293 ASP A OD2 1 
ATOM   2046 N  N   . ALA A 1 294 ? 158.295 147.083 105.375 1.00 48.21 ? 294 ALA A N   1 
ATOM   2047 C  CA  . ALA A 1 294 ? 157.186 146.729 104.511 1.00 48.21 ? 294 ALA A CA  1 
ATOM   2048 C  C   . ALA A 1 294 ? 155.937 146.403 105.302 1.00 48.21 ? 294 ALA A C   1 
ATOM   2049 O  O   . ALA A 1 294 ? 154.870 146.243 104.712 1.00 48.21 ? 294 ALA A O   1 
ATOM   2050 C  CB  . ALA A 1 294 ? 157.560 145.544 103.621 1.00 48.21 ? 294 ALA A CB  1 
ATOM   2051 N  N   . LEU A 1 295 ? 156.046 146.309 106.622 1.00 45.44 ? 295 LEU A N   1 
ATOM   2052 C  CA  . LEU A 1 295 ? 154.914 146.040 107.496 1.00 45.44 ? 295 LEU A CA  1 
ATOM   2053 C  C   . LEU A 1 295 ? 154.293 147.319 108.034 1.00 45.44 ? 295 LEU A C   1 
ATOM   2054 O  O   . LEU A 1 295 ? 153.676 147.311 109.098 1.00 45.44 ? 295 LEU A O   1 
ATOM   2055 C  CB  . LEU A 1 295 ? 155.321 145.131 108.651 1.00 45.44 ? 295 LEU A CB  1 
ATOM   2056 C  CG  . LEU A 1 295 ? 155.395 143.640 108.386 1.00 45.44 ? 295 LEU A CG  1 
ATOM   2057 C  CD1 . LEU A 1 295 ? 156.142 142.985 109.500 1.00 45.44 ? 295 LEU A CD1 1 
ATOM   2058 C  CD2 . LEU A 1 295 ? 153.999 143.115 108.365 1.00 45.44 ? 295 LEU A CD2 1 
ATOM   2059 N  N   . LEU A 1 296 ? 154.445 148.427 107.321 1.00 46.94 ? 296 LEU A N   1 
ATOM   2060 C  CA  . LEU A 1 296 ? 153.705 149.634 107.643 1.00 46.94 ? 296 LEU A CA  1 
ATOM   2061 C  C   . LEU A 1 296 ? 152.422 149.754 106.842 1.00 46.94 ? 296 LEU A C   1 
ATOM   2062 O  O   . LEU A 1 296 ? 151.590 150.604 107.166 1.00 46.94 ? 296 LEU A O   1 
ATOM   2063 C  CB  . LEU A 1 296 ? 154.568 150.877 107.405 1.00 46.94 ? 296 LEU A CB  1 
ATOM   2064 C  CG  . LEU A 1 296 ? 155.775 151.041 108.320 1.00 46.94 ? 296 LEU A CG  1 
ATOM   2065 C  CD1 . LEU A 1 296 ? 156.599 152.231 107.905 1.00 46.94 ? 296 LEU A CD1 1 
ATOM   2066 C  CD2 . LEU A 1 296 ? 155.321 151.208 109.733 1.00 46.94 ? 296 LEU A CD2 1 
ATOM   2067 N  N   . ASP A 1 297 ? 152.246 148.926 105.812 1.00 49.86 ? 297 ASP A N   1 
ATOM   2068 C  CA  . ASP A 1 297 ? 151.073 148.948 104.956 1.00 49.86 ? 297 ASP A CA  1 
ATOM   2069 C  C   . ASP A 1 297 ? 150.296 147.643 104.958 1.00 49.86 ? 297 ASP A C   1 
ATOM   2070 O  O   . ASP A 1 297 ? 149.228 147.582 104.344 1.00 49.86 ? 297 ASP A O   1 
ATOM   2071 C  CB  . ASP A 1 297 ? 151.470 149.273 103.513 1.00 49.86 ? 297 ASP A CB  1 
ATOM   2072 C  CG  . ASP A 1 297 ? 152.013 150.661 103.367 1.00 49.86 ? 297 ASP A CG  1 
ATOM   2073 O  OD1 . ASP A 1 297 ? 151.650 151.518 104.190 1.00 49.86 ? 297 ASP A OD1 1 
ATOM   2074 O  OD2 . ASP A 1 297 ? 152.798 150.897 102.428 1.00 49.86 ? 297 ASP A OD2 1 
ATOM   2075 N  N   . HIS A 1 298 ? 150.802 146.597 105.602 1.00 47.50 ? 298 HIS A N   1 
ATOM   2076 C  CA  . HIS A 1 298 ? 150.104 145.322 105.673 1.00 47.50 ? 298 HIS A CA  1 
ATOM   2077 C  C   . HIS A 1 298 ? 149.935 144.971 107.137 1.00 47.50 ? 298 HIS A C   1 
ATOM   2078 O  O   . HIS A 1 298 ? 150.925 144.835 107.857 1.00 47.50 ? 298 HIS A O   1 
ATOM   2079 C  CB  . HIS A 1 298 ? 150.872 144.230 104.934 1.00 47.50 ? 298 HIS A CB  1 
ATOM   2080 C  CG  . HIS A 1 298 ? 151.074 144.528 103.485 1.00 47.50 ? 298 HIS A CG  1 
ATOM   2081 N  ND1 . HIS A 1 298 ? 152.143 145.262 103.022 1.00 47.50 ? 298 HIS A ND1 1 
ATOM   2082 C  CD2 . HIS A 1 298 ? 150.343 144.204 102.395 1.00 47.50 ? 298 HIS A CD2 1 
ATOM   2083 C  CE1 . HIS A 1 298 ? 152.064 145.374 101.710 1.00 47.50 ? 298 HIS A CE1 1 
ATOM   2084 N  NE2 . HIS A 1 298 ? 150.979 144.743 101.305 1.00 47.50 ? 298 HIS A NE2 1 
ATOM   2085 N  N   . SER A 1 299 ? 148.689 144.837 107.575 1.00 45.38 ? 299 SER A N   1 
ATOM   2086 C  CA  . SER A 1 299 ? 148.384 144.651 108.984 1.00 45.38 ? 299 SER A CA  1 
ATOM   2087 C  C   . SER A 1 299 ? 148.378 143.193 109.404 1.00 45.38 ? 299 SER A C   1 
ATOM   2088 O  O   . SER A 1 299 ? 148.952 142.864 110.441 1.00 45.38 ? 299 SER A O   1 
ATOM   2089 C  CB  . SER A 1 299 ? 147.040 145.292 109.316 1.00 45.38 ? 299 SER A CB  1 
ATOM   2090 O  OG  . SER A 1 299 ? 145.999 144.685 108.578 1.00 45.38 ? 299 SER A OG  1 
ATOM   2091 N  N   . ASN A 1 300 ? 147.731 142.311 108.649 1.00 45.77 ? 300 ASN A N   1 
ATOM   2092 C  CA  . ASN A 1 300 ? 147.978 140.890 108.833 1.00 45.77 ? 300 ASN A CA  1 
ATOM   2093 C  C   . ASN A 1 300 ? 149.423 140.547 108.520 1.00 45.77 ? 300 ASN A C   1 
ATOM   2094 O  O   . ASN A 1 300 ? 150.058 141.146 107.651 1.00 45.77 ? 300 ASN A O   1 
ATOM   2095 C  CB  . ASN A 1 300 ? 147.090 140.035 107.939 1.00 45.77 ? 300 ASN A CB  1 
ATOM   2096 C  CG  . ASN A 1 300 ? 145.782 139.730 108.559 1.00 45.77 ? 300 ASN A CG  1 
ATOM   2097 O  OD1 . ASN A 1 300 ? 145.697 139.504 109.754 1.00 45.77 ? 300 ASN A OD1 1 
ATOM   2098 N  ND2 . ASN A 1 300 ? 144.749 139.663 107.748 1.00 45.77 ? 300 ASN A ND2 1 
ATOM   2099 N  N   . ALA A 1 301 ? 149.942 139.566 109.245 1.00 46.44 ? 301 ALA A N   1 
ATOM   2100 C  CA  . ALA A 1 301 ? 151.206 138.982 108.859 1.00 46.44 ? 301 ALA A CA  1 
ATOM   2101 C  C   . ALA A 1 301 ? 151.036 137.912 107.796 1.00 46.44 ? 301 ALA A C   1 
ATOM   2102 O  O   . ALA A 1 301 ? 152.021 137.549 107.153 1.00 46.44 ? 301 ALA A O   1 
ATOM   2103 C  CB  . ALA A 1 301 ? 151.900 138.398 110.077 1.00 46.44 ? 301 ALA A CB  1 
ATOM   2104 N  N   . PHE A 1 302 ? 149.819 137.405 107.582 1.00 47.73 ? 302 PHE A N   1 
ATOM   2105 C  CA  . PHE A 1 302 ? 149.631 136.350 106.591 1.00 47.73 ? 302 PHE A CA  1 
ATOM   2106 C  C   . PHE A 1 302 ? 149.716 136.847 105.157 1.00 47.73 ? 302 PHE A C   1 
ATOM   2107 O  O   . PHE A 1 302 ? 149.795 136.024 104.240 1.00 47.73 ? 302 PHE A O   1 
ATOM   2108 C  CB  . PHE A 1 302 ? 148.286 135.662 106.751 1.00 47.73 ? 302 PHE A CB  1 
ATOM   2109 C  CG  . PHE A 1 302 ? 148.186 134.786 107.939 1.00 47.73 ? 302 PHE A CG  1 
ATOM   2110 C  CD1 . PHE A 1 302 ? 148.843 133.581 107.968 1.00 47.73 ? 302 PHE A CD1 1 
ATOM   2111 C  CD2 . PHE A 1 302 ? 147.371 135.123 108.995 1.00 47.73 ? 302 PHE A CD2 1 
ATOM   2112 C  CE1 . PHE A 1 302 ? 148.734 132.756 109.056 1.00 47.73 ? 302 PHE A CE1 1 
ATOM   2113 C  CE2 . PHE A 1 302 ? 147.251 134.292 110.077 1.00 47.73 ? 302 PHE A CE2 1 
ATOM   2114 C  CZ  . PHE A 1 302 ? 147.933 133.113 110.111 1.00 47.73 ? 302 PHE A CZ  1 
ATOM   2115 N  N   . SER A 1 303 ? 149.675 138.156 104.930 1.00 48.56 ? 303 SER A N   1 
ATOM   2116 C  CA  . SER A 1 303 ? 149.753 138.666 103.571 1.00 48.56 ? 303 SER A CA  1 
ATOM   2117 C  C   . SER A 1 303 ? 151.177 138.819 103.072 1.00 48.56 ? 303 SER A C   1 
ATOM   2118 O  O   . SER A 1 303 ? 151.364 139.260 101.935 1.00 48.56 ? 303 SER A O   1 
ATOM   2119 C  CB  . SER A 1 303 ? 149.035 140.005 103.461 1.00 48.56 ? 303 SER A CB  1 
ATOM   2120 O  OG  . SER A 1 303 ? 149.654 140.990 104.260 1.00 48.56 ? 303 SER A OG  1 
ATOM   2121 N  N   . LEU A 1 304 ? 152.181 138.488 103.881 1.00 48.87 ? 304 LEU A N   1 
ATOM   2122 C  CA  . LEU A 1 304 ? 153.562 138.536 103.437 1.00 48.87 ? 304 LEU A CA  1 
ATOM   2123 C  C   . LEU A 1 304 ? 154.209 137.170 103.314 1.00 48.87 ? 304 LEU A C   1 
ATOM   2124 O  O   . LEU A 1 304 ? 155.314 137.075 102.775 1.00 48.87 ? 304 LEU A O   1 
ATOM   2125 C  CB  . LEU A 1 304 ? 154.405 139.383 104.385 1.00 48.87 ? 304 LEU A CB  1 
ATOM   2126 C  CG  . LEU A 1 304 ? 154.071 140.856 104.439 1.00 48.87 ? 304 LEU A CG  1 
ATOM   2127 C  CD1 . LEU A 1 304 ? 155.099 141.496 105.276 1.00 48.87 ? 304 LEU A CD1 1 
ATOM   2128 C  CD2 . LEU A 1 304 ? 154.093 141.440 103.059 1.00 48.87 ? 304 LEU A CD2 1 
ATOM   2129 N  N   . MET A 1 305 ? 153.583 136.147 103.776 1.00 50.74 ? 305 MET A N   1 
ATOM   2130 C  CA  . MET A 1 305 ? 154.199 134.836 103.776 1.00 50.74 ? 305 MET A CA  1 
ATOM   2131 C  C   . MET A 1 305 ? 153.661 134.025 102.622 1.00 50.74 ? 305 MET A C   1 
ATOM   2132 O  O   . MET A 1 305 ? 152.497 134.210 102.252 1.00 50.74 ? 305 MET A O   1 
ATOM   2133 C  CB  . MET A 1 305 ? 153.911 134.139 105.092 1.00 50.74 ? 305 MET A CB  1 
ATOM   2134 C  CG  . MET A 1 305 ? 154.523 134.889 106.212 1.00 50.74 ? 305 MET A CG  1 
ATOM   2135 S  SD  . MET A 1 305 ? 154.251 134.180 107.808 1.00 50.74 ? 305 MET A SD  1 
ATOM   2136 C  CE  . MET A 1 305 ? 155.032 135.469 108.751 1.00 50.74 ? 305 MET A CE  1 
ATOM   2137 N  N   . PRO A 1 306 ? 154.448 133.142 102.021 1.00 50.05 ? 306 PRO A N   1 
ATOM   2138 C  CA  . PRO A 1 306 ? 154.006 132.500 100.783 1.00 50.05 ? 306 PRO A CA  1 
ATOM   2139 C  C   . PRO A 1 306 ? 152.931 131.454 101.007 1.00 50.05 ? 306 PRO A C   1 
ATOM   2140 O  O   . PRO A 1 306 ? 152.962 130.690 101.972 1.00 50.05 ? 306 PRO A O   1 
ATOM   2141 C  CB  . PRO A 1 306 ? 155.289 131.870 100.240 1.00 50.05 ? 306 PRO A CB  1 
ATOM   2142 C  CG  . PRO A 1 306 ? 156.132 131.679 101.415 1.00 50.05 ? 306 PRO A CG  1 
ATOM   2143 C  CD  . PRO A 1 306 ? 155.845 132.815 102.329 1.00 50.05 ? 306 PRO A CD  1 
ATOM   2144 N  N   . LYS A 1 307 ? 151.968 131.437 100.086 1.00 53.76 ? 307 LYS A N   1 
ATOM   2145 C  CA  . LYS A 1 307 ? 150.858 130.500 100.156 1.00 53.76 ? 307 LYS A CA  1 
ATOM   2146 C  C   . LYS A 1 307 ? 151.334 129.088 99.864  1.00 53.76 ? 307 LYS A C   1 
ATOM   2147 O  O   . LYS A 1 307 ? 151.631 128.745 98.716  1.00 53.76 ? 307 LYS A O   1 
ATOM   2148 C  CB  . LYS A 1 307 ? 149.768 130.878 99.160  1.00 53.76 ? 307 LYS A CB  1 
ATOM   2149 C  CG  . LYS A 1 307 ? 148.574 129.948 99.226  1.00 53.76 ? 307 LYS A CG  1 
ATOM   2150 C  CD  . LYS A 1 307 ? 147.526 130.275 98.187  1.00 53.76 ? 307 LYS A CD  1 
ATOM   2151 C  CE  . LYS A 1 307 ? 146.414 131.110 98.772  1.00 53.76 ? 307 LYS A CE  1 
ATOM   2152 N  NZ  . LYS A 1 307 ? 146.800 132.540 98.903  1.00 53.76 ? 307 LYS A NZ  1 
ATOM   2153 N  N   . ASN A 1 308 ? 151.391 128.263 100.903 1.00 54.33 ? 308 ASN A N   1 
ATOM   2154 C  CA  . ASN A 1 308 ? 151.784 126.869 100.765 1.00 54.33 ? 308 ASN A CA  1 
ATOM   2155 C  C   . ASN A 1 308 ? 150.816 126.022 101.583 1.00 54.33 ? 308 ASN A C   1 
ATOM   2156 O  O   . ASN A 1 308 ? 149.692 126.434 101.892 1.00 54.33 ? 308 ASN A O   1 
ATOM   2157 C  CB  . ASN A 1 308 ? 153.249 126.634 101.156 1.00 54.33 ? 308 ASN A CB  1 
ATOM   2158 C  CG  . ASN A 1 308 ? 153.562 127.043 102.572 1.00 54.33 ? 308 ASN A CG  1 
ATOM   2159 O  OD1 . ASN A 1 308 ? 152.727 127.575 103.294 1.00 54.33 ? 308 ASN A OD1 1 
ATOM   2160 N  ND2 . ASN A 1 308 ? 154.777 126.753 102.994 1.00 54.33 ? 308 ASN A ND2 1 
ATOM   2161 N  N   . ALA A 1 309 ? 151.250 124.809 101.912 1.00 53.94 ? 309 ALA A N   1 
ATOM   2162 C  CA  . ALA A 1 309 ? 150.428 123.863 102.645 1.00 53.94 ? 309 ALA A CA  1 
ATOM   2163 C  C   . ALA A 1 309 ? 150.089 124.313 104.055 1.00 53.94 ? 309 ALA A C   1 
ATOM   2164 O  O   . ALA A 1 309 ? 149.047 123.912 104.576 1.00 53.94 ? 309 ALA A O   1 
ATOM   2165 C  CB  . ALA A 1 309 ? 151.137 122.510 102.714 1.00 53.94 ? 309 ALA A CB  1 
ATOM   2166 N  N   . TRP A 1 310 ? 150.925 125.131 104.685 1.00 52.05 ? 310 TRP A N   1 
ATOM   2167 C  CA  . TRP A 1 310 ? 150.724 125.342 106.111 1.00 52.05 ? 310 TRP A CA  1 
ATOM   2168 C  C   . TRP A 1 310 ? 150.041 126.674 106.388 1.00 52.05 ? 310 TRP A C   1 
ATOM   2169 O  O   . TRP A 1 310 ? 149.320 126.802 107.382 1.00 52.05 ? 310 TRP A O   1 
ATOM   2170 C  CB  . TRP A 1 310 ? 152.054 125.237 106.871 1.00 52.05 ? 310 TRP A CB  1 
ATOM   2171 C  CG  . TRP A 1 310 ? 152.716 123.848 106.829 1.00 52.05 ? 310 TRP A CG  1 
ATOM   2172 C  CD1 . TRP A 1 310 ? 152.381 122.792 106.027 1.00 52.05 ? 310 TRP A CD1 1 
ATOM   2173 C  CD2 . TRP A 1 310 ? 153.742 123.359 107.701 1.00 52.05 ? 310 TRP A CD2 1 
ATOM   2174 N  NE1 . TRP A 1 310 ? 153.173 121.710 106.297 1.00 52.05 ? 310 TRP A NE1 1 
ATOM   2175 C  CE2 . TRP A 1 310 ? 154.007 122.025 107.330 1.00 52.05 ? 310 TRP A CE2 1 
ATOM   2176 C  CE3 . TRP A 1 310 ? 154.476 123.925 108.743 1.00 52.05 ? 310 TRP A CE3 1 
ATOM   2177 C  CZ2 . TRP A 1 310 ? 154.966 121.252 107.959 1.00 52.05 ? 310 TRP A CZ2 1 
ATOM   2178 C  CZ3 . TRP A 1 310 ? 155.420 123.157 109.369 1.00 52.05 ? 310 TRP A CZ3 1 
ATOM   2179 C  CH2 . TRP A 1 310 ? 155.659 121.832 108.976 1.00 52.05 ? 310 TRP A CH2 1 
ATOM   2180 N  N   . ARG A 1 311 ? 150.242 127.666 105.513 1.00 50.61 ? 311 ARG A N   1 
ATOM   2181 C  CA  . ARG A 1 311 ? 149.519 128.932 105.619 1.00 50.61 ? 311 ARG A CA  1 
ATOM   2182 C  C   . ARG A 1 311 ? 148.027 128.736 105.431 1.00 50.61 ? 311 ARG A C   1 
ATOM   2183 O  O   . ARG A 1 311 ? 147.221 129.401 106.087 1.00 50.61 ? 311 ARG A O   1 
ATOM   2184 C  CB  . ARG A 1 311 ? 150.052 129.916 104.585 1.00 50.61 ? 311 ARG A CB  1 
ATOM   2185 C  CG  . ARG A 1 311 ? 149.403 131.274 104.558 1.00 50.61 ? 311 ARG A CG  1 
ATOM   2186 C  CD  . ARG A 1 311 ? 150.147 132.111 103.561 1.00 50.61 ? 311 ARG A CD  1 
ATOM   2187 N  NE  . ARG A 1 311 ? 149.575 133.424 103.332 1.00 50.61 ? 311 ARG A NE  1 
ATOM   2188 C  CZ  . ARG A 1 311 ? 148.684 133.669 102.385 1.00 50.61 ? 311 ARG A CZ  1 
ATOM   2189 N  NH1 . ARG A 1 311 ? 148.267 132.682 101.612 1.00 50.61 ? 311 ARG A NH1 1 
ATOM   2190 N  NH2 . ARG A 1 311 ? 148.215 134.890 102.210 1.00 50.61 ? 311 ARG A NH2 1 
ATOM   2191 N  N   . ASP A 1 312 ? 147.641 127.800 104.571 1.00 53.65 ? 312 ASP A N   1 
ATOM   2192 C  CA  . ASP A 1 312 ? 146.237 127.451 104.458 1.00 53.65 ? 312 ASP A CA  1 
ATOM   2193 C  C   . ASP A 1 312 ? 145.759 126.658 105.665 1.00 53.65 ? 312 ASP A C   1 
ATOM   2194 O  O   . ASP A 1 312 ? 144.553 126.479 105.831 1.00 53.65 ? 312 ASP A O   1 
ATOM   2195 C  CB  . ASP A 1 312 ? 145.989 126.660 103.175 1.00 53.65 ? 312 ASP A CB  1 
ATOM   2196 C  CG  . ASP A 1 312 ? 146.177 127.500 101.928 1.00 53.65 ? 312 ASP A CG  1 
ATOM   2197 O  OD1 . ASP A 1 312 ? 146.044 128.732 102.027 1.00 53.65 ? 312 ASP A OD1 1 
ATOM   2198 O  OD2 . ASP A 1 312 ? 146.427 126.935 100.844 1.00 53.65 ? 312 ASP A OD2 1 
ATOM   2199 N  N   . ALA A 1 313 ? 146.672 126.161 106.501 1.00 48.18 ? 313 ALA A N   1 
ATOM   2200 C  CA  . ALA A 1 313 ? 146.324 125.395 107.689 1.00 48.18 ? 313 ALA A CA  1 
ATOM   2201 C  C   . ALA A 1 313 ? 146.356 126.310 108.895 1.00 48.18 ? 313 ALA A C   1 
ATOM   2202 O  O   . ALA A 1 313 ? 145.472 126.228 109.747 1.00 48.18 ? 313 ALA A O   1 
ATOM   2203 C  CB  . ALA A 1 313 ? 147.081 124.069 107.713 1.00 48.18 ? 313 ALA A CB  1 
ATOM   2204 N  N   . ALA A 1 314 ? 147.377 127.143 109.018 1.00 47.36 ? 314 ALA A N   1 
ATOM   2205 C  CA  . ALA A 1 314 ? 147.379 128.170 110.038 1.00 47.36 ? 314 ALA A CA  1 
ATOM   2206 C  C   . ALA A 1 314 ? 146.181 129.092 110.087 1.00 47.36 ? 314 ALA A C   1 
ATOM   2207 O  O   . ALA A 1 314 ? 145.715 129.416 111.183 1.00 47.36 ? 314 ALA A O   1 
ATOM   2208 C  CB  . ALA A 1 314 ? 148.801 128.727 110.140 1.00 47.36 ? 314 ALA A CB  1 
ATOM   2209 N  N   . VAL A 1 315 ? 145.689 129.536 108.936 1.00 45.48 ? 315 VAL A N   1 
ATOM   2210 C  CA  . VAL A 1 315 ? 144.539 130.420 108.875 1.00 45.48 ? 315 VAL A CA  1 
ATOM   2211 C  C   . VAL A 1 315 ? 143.201 129.799 109.246 1.00 45.48 ? 315 VAL A C   1 
ATOM   2212 O  O   . VAL A 1 315 ? 142.315 130.467 109.773 1.00 45.48 ? 315 VAL A O   1 
ATOM   2213 C  CB  . VAL A 1 315 ? 144.664 131.131 107.517 1.00 45.48 ? 315 VAL A CB  1 
ATOM   2214 C  CG1 . VAL A 1 315 ? 144.576 130.167 106.376 1.00 45.48 ? 315 VAL A CG1 1 
ATOM   2215 C  CG2 . VAL A 1 315 ? 143.659 132.222 107.393 1.00 45.48 ? 315 VAL A CG2 1 
ATOM   2216 N  N   . ILE A 1 316 ? 143.039 128.509 108.965 1.00 43.52 ? 316 ILE A N   1 
ATOM   2217 C  CA  . ILE A 1 316 ? 141.909 127.788 109.527 1.00 43.52 ? 316 ILE A CA  1 
ATOM   2218 C  C   . ILE A 1 316 ? 141.845 127.807 111.041 1.00 43.52 ? 316 ILE A C   1 
ATOM   2219 O  O   . ILE A 1 316 ? 140.786 128.060 111.621 1.00 43.52 ? 316 ILE A O   1 
ATOM   2220 C  CB  . ILE A 1 316 ? 141.852 126.359 108.967 1.00 43.52 ? 316 ILE A CB  1 
ATOM   2221 C  CG1 . ILE A 1 316 ? 141.718 126.386 107.452 1.00 43.52 ? 316 ILE A CG1 1 
ATOM   2222 C  CG2 . ILE A 1 316 ? 140.693 125.587 109.536 1.00 43.52 ? 316 ILE A CG2 1 
ATOM   2223 C  CD1 . ILE A 1 316 ? 141.822 125.023 106.831 1.00 43.52 ? 316 ILE A CD1 1 
ATOM   2224 N  N   . LEU A 1 317 ? 142.978 127.609 111.707 1.00 42.19 ? 317 LEU A N   1 
ATOM   2225 C  CA  . LEU A 1 317 ? 143.027 127.550 113.159 1.00 42.19 ? 317 LEU A CA  1 
ATOM   2226 C  C   . LEU A 1 317 ? 142.599 128.874 113.777 1.00 42.19 ? 317 LEU A C   1 
ATOM   2227 O  O   . LEU A 1 317 ? 141.830 128.870 114.738 1.00 42.19 ? 317 LEU A O   1 
ATOM   2228 C  CB  . LEU A 1 317 ? 144.262 126.773 113.590 1.00 42.19 ? 317 LEU A CB  1 
ATOM   2229 C  CG  . LEU A 1 317 ? 144.332 125.355 113.041 1.00 42.19 ? 317 LEU A CG  1 
ATOM   2230 C  CD1 . LEU A 1 317 ? 145.604 124.686 113.478 1.00 42.19 ? 317 LEU A CD1 1 
ATOM   2231 C  CD2 . LEU A 1 317 ? 143.136 124.541 113.436 1.00 42.19 ? 317 LEU A CD2 1 
ATOM   2232 N  N   . MET A 1 318 ? 143.089 129.998 113.276 1.00 43.01 ? 318 MET A N   1 
ATOM   2233 C  CA  . MET A 1 318 ? 142.544 131.300 113.597 1.00 43.01 ? 318 MET A CA  1 
ATOM   2234 C  C   . MET A 1 318 ? 141.083 131.694 113.415 1.00 43.01 ? 318 MET A C   1 
ATOM   2235 O  O   . MET A 1 318 ? 140.544 132.406 114.262 1.00 43.01 ? 318 MET A O   1 
ATOM   2236 C  CB  . MET A 1 318 ? 143.622 132.300 113.174 1.00 43.01 ? 318 MET A CB  1 
ATOM   2237 C  CG  . MET A 1 318 ? 144.977 131.955 113.709 1.00 43.01 ? 318 MET A CG  1 
ATOM   2238 S  SD  . MET A 1 318 ? 145.101 132.171 115.478 1.00 43.01 ? 318 MET A SD  1 
ATOM   2239 C  CE  . MET A 1 318 ? 145.241 133.941 115.543 1.00 43.01 ? 318 MET A CE  1 
ATOM   2240 N  N   . LEU A 1 319 ? 140.448 131.304 112.308 1.00 42.09 ? 319 LEU A N   1 
ATOM   2241 C  CA  . LEU A 1 319 ? 138.994 131.264 112.254 1.00 42.09 ? 319 LEU A CA  1 
ATOM   2242 C  C   . LEU A 1 319 ? 138.258 130.489 113.325 1.00 42.09 ? 319 LEU A C   1 
ATOM   2243 O  O   . LEU A 1 319 ? 137.144 130.859 113.698 1.00 42.09 ? 319 LEU A O   1 
ATOM   2244 C  CB  . LEU A 1 319 ? 138.465 130.825 110.895 1.00 42.09 ? 319 LEU A CB  1 
ATOM   2245 C  CG  . LEU A 1 319 ? 138.281 131.797 109.742 1.00 42.09 ? 319 LEU A CG  1 
ATOM   2246 C  CD1 . LEU A 1 319 ? 137.260 132.840 110.093 1.00 42.09 ? 319 LEU A CD1 1 
ATOM   2247 C  CD2 . LEU A 1 319 ? 139.556 132.424 109.386 1.00 42.09 ? 319 LEU A CD2 1 
ATOM   2248 N  N   . ILE A 1 320 ? 138.844 129.395 113.800 1.00 42.45 ? 320 ILE A N   1 
ATOM   2249 C  CA  . ILE A 1 320 ? 138.207 128.603 114.836 1.00 42.45 ? 320 ILE A CA  1 
ATOM   2250 C  C   . ILE A 1 320 ? 138.390 129.257 116.199 1.00 42.45 ? 320 ILE A C   1 
ATOM   2251 O  O   . ILE A 1 320 ? 137.491 129.204 117.036 1.00 42.45 ? 320 ILE A O   1 
ATOM   2252 C  CB  . ILE A 1 320 ? 138.749 127.165 114.791 1.00 42.45 ? 320 ILE A CB  1 
ATOM   2253 C  CG1 . ILE A 1 320 ? 138.448 126.539 113.436 1.00 42.45 ? 320 ILE A CG1 1 
ATOM   2254 C  CG2 . ILE A 1 320 ? 138.119 126.293 115.845 1.00 42.45 ? 320 ILE A CG2 1 
ATOM   2255 C  CD1 . ILE A 1 320 ? 139.100 125.209 113.234 1.00 42.45 ? 320 ILE A CD1 1 
ATOM   2256 N  N   . HIS A 1 321 ? 139.515 129.922 116.440 1.00 43.98 ? 321 HIS A N   1 
ATOM   2257 C  CA  . HIS A 1 321 ? 139.686 130.599 117.718 1.00 43.98 ? 321 HIS A CA  1 
ATOM   2258 C  C   . HIS A 1 321 ? 138.891 131.895 117.777 1.00 43.98 ? 321 HIS A C   1 
ATOM   2259 O  O   . HIS A 1 321 ? 138.277 132.199 118.801 1.00 43.98 ? 321 HIS A O   1 
ATOM   2260 C  CB  . HIS A 1 321 ? 141.159 130.875 117.973 1.00 43.98 ? 321 HIS A CB  1 
ATOM   2261 C  CG  . HIS A 1 321 ? 141.455 131.348 119.359 1.00 43.98 ? 321 HIS A CG  1 
ATOM   2262 N  ND1 . HIS A 1 321 ? 142.654 131.925 119.703 1.00 43.98 ? 321 HIS A ND1 1 
ATOM   2263 C  CD2 . HIS A 1 321 ? 140.720 131.313 120.492 1.00 43.98 ? 321 HIS A CD2 1 
ATOM   2264 C  CE1 . HIS A 1 321 ? 142.646 132.229 120.985 1.00 43.98 ? 321 HIS A CE1 1 
ATOM   2265 N  NE2 . HIS A 1 321 ? 141.479 131.876 121.487 1.00 43.98 ? 321 HIS A NE2 1 
ATOM   2266 N  N   . GLN A 1 322 ? 138.884 132.672 116.700 1.00 45.03 ? 322 GLN A N   1 
ATOM   2267 C  CA  . GLN A 1 322 ? 138.285 134.000 116.709 1.00 45.03 ? 322 GLN A CA  1 
ATOM   2268 C  C   . GLN A 1 322 ? 136.766 133.979 116.634 1.00 45.03 ? 322 GLN A C   1 
ATOM   2269 O  O   . GLN A 1 322 ? 136.135 135.011 116.854 1.00 45.03 ? 322 GLN A O   1 
ATOM   2270 C  CB  . GLN A 1 322 ? 138.845 134.832 115.563 1.00 45.03 ? 322 GLN A CB  1 
ATOM   2271 C  CG  . GLN A 1 322 ? 140.264 135.245 115.764 1.00 45.03 ? 322 GLN A CG  1 
ATOM   2272 C  CD  . GLN A 1 322 ? 140.813 135.920 114.553 1.00 45.03 ? 322 GLN A CD  1 
ATOM   2273 O  OE1 . GLN A 1 322 ? 140.151 136.002 113.526 1.00 45.03 ? 322 GLN A OE1 1 
ATOM   2274 N  NE2 . GLN A 1 322 ? 142.032 136.412 114.656 1.00 45.03 ? 322 GLN A NE2 1 
ATOM   2275 N  N   . PHE A 1 323 ? 136.166 132.840 116.331 1.00 49.77 ? 323 PHE A N   1 
ATOM   2276 C  CA  . PHE A 1 323 ? 134.719 132.712 116.332 1.00 49.77 ? 323 PHE A CA  1 
ATOM   2277 C  C   . PHE A 1 323 ? 134.202 132.134 117.638 1.00 49.77 ? 323 PHE A C   1 
ATOM   2278 O  O   . PHE A 1 323 ? 133.011 132.254 117.934 1.00 49.77 ? 323 PHE A O   1 
ATOM   2279 C  CB  . PHE A 1 323 ? 134.287 131.839 115.147 1.00 49.77 ? 323 PHE A CB  1 
ATOM   2280 C  CG  . PHE A 1 323 ? 132.802 131.772 114.925 1.00 49.77 ? 323 PHE A CG  1 
ATOM   2281 C  CD1 . PHE A 1 323 ? 132.127 132.817 114.319 1.00 49.77 ? 323 PHE A CD1 1 
ATOM   2282 C  CD2 . PHE A 1 323 ? 132.084 130.645 115.298 1.00 49.77 ? 323 PHE A CD2 1 
ATOM   2283 C  CE1 . PHE A 1 323 ? 130.755 132.745 114.107 1.00 49.77 ? 323 PHE A CE1 1 
ATOM   2284 C  CE2 . PHE A 1 323 ? 130.713 130.569 115.092 1.00 49.77 ? 323 PHE A CE2 1 
ATOM   2285 C  CZ  . PHE A 1 323 ? 130.050 131.618 114.496 1.00 49.77 ? 323 PHE A CZ  1 
ATOM   2286 N  N   . ILE A 1 324 ? 135.078 131.530 118.438 1.00 49.33 ? 324 ILE A N   1 
ATOM   2287 C  CA  . ILE A 1 324 ? 134.673 130.998 119.733 1.00 49.33 ? 324 ILE A CA  1 
ATOM   2288 C  C   . ILE A 1 324 ? 134.879 132.027 120.835 1.00 49.33 ? 324 ILE A C   1 
ATOM   2289 O  O   . ILE A 1 324 ? 134.025 132.184 121.711 1.00 49.33 ? 324 ILE A O   1 
ATOM   2290 C  CB  . ILE A 1 324 ? 135.416 129.682 120.007 1.00 49.33 ? 324 ILE A CB  1 
ATOM   2291 C  CG1 . ILE A 1 324 ? 134.979 128.629 118.996 1.00 49.33 ? 324 ILE A CG1 1 
ATOM   2292 C  CG2 . ILE A 1 324 ? 135.180 129.189 121.397 1.00 49.33 ? 324 ILE A CG2 1 
ATOM   2293 C  CD1 . ILE A 1 324 ? 133.504 128.354 119.003 1.00 49.33 ? 324 ILE A CD1 1 
ATOM   2294 N  N   . THR A 1 325 ? 135.974 132.790 120.795 1.00 49.98 ? 325 THR A N   1 
ATOM   2295 C  CA  . THR A 1 325 ? 136.100 133.899 121.736 1.00 49.98 ? 325 THR A CA  1 
ATOM   2296 C  C   . THR A 1 325 ? 135.239 135.092 121.349 1.00 49.98 ? 325 THR A C   1 
ATOM   2297 O  O   . THR A 1 325 ? 135.196 136.070 122.099 1.00 49.98 ? 325 THR A O   1 
ATOM   2298 C  CB  . THR A 1 325 ? 137.543 134.353 121.873 1.00 49.98 ? 325 THR A CB  1 
ATOM   2299 O  OG1 . THR A 1 325 ? 137.629 135.298 122.939 1.00 49.98 ? 325 THR A OG1 1 
ATOM   2300 C  CG2 . THR A 1 325 ? 137.988 135.036 120.622 1.00 49.98 ? 325 THR A CG2 1 
ATOM   2301 N  N   . PHE A 1 326 ? 134.577 135.047 120.191 1.00 52.47 ? 326 PHE A N   1 
ATOM   2302 C  CA  . PHE A 1 326 ? 133.502 135.990 119.909 1.00 52.47 ? 326 PHE A CA  1 
ATOM   2303 C  C   . PHE A 1 326 ? 132.305 135.717 120.803 1.00 52.47 ? 326 PHE A C   1 
ATOM   2304 O  O   . PHE A 1 326 ? 131.762 136.629 121.430 1.00 52.47 ? 326 PHE A O   1 
ATOM   2305 C  CB  . PHE A 1 326 ? 133.089 135.907 118.439 1.00 52.47 ? 326 PHE A CB  1 
ATOM   2306 C  CG  . PHE A 1 326 ? 131.943 136.811 118.077 1.00 52.47 ? 326 PHE A CG  1 
ATOM   2307 C  CD1 . PHE A 1 326 ? 132.142 138.164 117.886 1.00 52.47 ? 326 PHE A CD1 1 
ATOM   2308 C  CD2 . PHE A 1 326 ? 130.667 136.305 117.929 1.00 52.47 ? 326 PHE A CD2 1 
ATOM   2309 C  CE1 . PHE A 1 326 ? 131.090 138.987 117.558 1.00 52.47 ? 326 PHE A CE1 1 
ATOM   2310 C  CE2 . PHE A 1 326 ? 129.615 137.134 117.615 1.00 52.47 ? 326 PHE A CE2 1 
ATOM   2311 C  CZ  . PHE A 1 326 ? 129.830 138.473 117.421 1.00 52.47 ? 326 PHE A CZ  1 
ATOM   2312 N  N   . GLY A 1 327 ? 131.876 134.458 120.866 1.00 54.56 ? 327 GLY A N   1 
ATOM   2313 C  CA  . GLY A 1 327 ? 130.660 134.130 121.578 1.00 54.56 ? 327 GLY A CA  1 
ATOM   2314 C  C   . GLY A 1 327 ? 130.759 134.253 123.081 1.00 54.56 ? 327 GLY A C   1 
ATOM   2315 O  O   . GLY A 1 327 ? 129.732 134.393 123.745 1.00 54.56 ? 327 GLY A O   1 
ATOM   2316 N  N   . PHE A 1 328 ? 131.967 134.211 123.627 1.00 56.43 ? 328 PHE A N   1 
ATOM   2317 C  CA  . PHE A 1 328 ? 132.225 134.437 125.039 1.00 56.43 ? 328 PHE A CA  1 
ATOM   2318 C  C   . PHE A 1 328 ? 132.404 135.902 125.369 1.00 56.43 ? 328 PHE A C   1 
ATOM   2319 O  O   . PHE A 1 328 ? 132.663 136.235 126.528 1.00 56.43 ? 328 PHE A O   1 
ATOM   2320 C  CB  . PHE A 1 328 ? 133.486 133.691 125.446 1.00 56.43 ? 328 PHE A CB  1 
ATOM   2321 C  CG  . PHE A 1 328 ? 133.328 132.216 125.475 1.00 56.43 ? 328 PHE A CG  1 
ATOM   2322 C  CD1 . PHE A 1 328 ? 132.160 131.638 125.901 1.00 56.43 ? 328 PHE A CD1 1 
ATOM   2323 C  CD2 . PHE A 1 328 ? 134.319 131.408 124.971 1.00 56.43 ? 328 PHE A CD2 1 
ATOM   2324 C  CE1 . PHE A 1 328 ? 132.028 130.276 125.908 1.00 56.43 ? 328 PHE A CE1 1 
ATOM   2325 C  CE2 . PHE A 1 328 ? 134.165 130.053 124.946 1.00 56.43 ? 328 PHE A CE2 1 
ATOM   2326 C  CZ  . PHE A 1 328 ? 133.027 129.488 125.424 1.00 56.43 ? 328 PHE A CZ  1 
ATOM   2327 N  N   . ALA A 1 329 ? 132.318 136.777 124.380 1.00 55.71 ? 329 ALA A N   1 
ATOM   2328 C  CA  . ALA A 1 329 ? 132.472 138.202 124.596 1.00 55.71 ? 329 ALA A CA  1 
ATOM   2329 C  C   . ALA A 1 329 ? 131.217 138.977 124.263 1.00 55.71 ? 329 ALA A C   1 
ATOM   2330 O  O   . ALA A 1 329 ? 131.152 140.171 124.562 1.00 55.71 ? 329 ALA A O   1 
ATOM   2331 C  CB  . ALA A 1 329 ? 133.639 138.750 123.762 1.00 55.71 ? 329 ALA A CB  1 
ATOM   2332 N  N   . CYS A 1 330 ? 130.228 138.334 123.656 1.00 60.54 ? 330 CYS A N   1 
ATOM   2333 C  CA  . CYS A 1 330 ? 128.952 138.946 123.347 1.00 60.54 ? 330 CYS A CA  1 
ATOM   2334 C  C   . CYS A 1 330 ? 127.852 138.508 124.300 1.00 60.54 ? 330 CYS A C   1 
ATOM   2335 O  O   . CYS A 1 330 ? 126.908 139.272 124.513 1.00 60.54 ? 330 CYS A O   1 
ATOM   2336 C  CB  . CYS A 1 330 ? 128.563 138.610 121.902 1.00 60.54 ? 330 CYS A CB  1 
ATOM   2337 S  SG  . CYS A 1 330 ? 127.105 139.426 121.267 1.00 60.54 ? 330 CYS A SG  1 
ATOM   2338 N  N   . THR A 1 331 ? 127.968 137.319 124.906 1.00 59.46 ? 331 THR A N   1 
ATOM   2339 C  CA  . THR A 1 331 ? 127.019 136.761 125.871 1.00 59.46 ? 331 THR A CA  1 
ATOM   2340 C  C   . THR A 1 331 ? 126.785 137.635 127.112 1.00 59.46 ? 331 THR A C   1 
ATOM   2341 O  O   . THR A 1 331 ? 125.617 137.788 127.487 1.00 59.46 ? 331 THR A O   1 
ATOM   2342 C  CB  . THR A 1 331 ? 127.447 135.344 126.262 1.00 59.46 ? 331 THR A CB  1 
ATOM   2343 O  OG1 . THR A 1 331 ? 127.514 134.547 125.082 1.00 59.46 ? 331 THR A OG1 1 
ATOM   2344 C  CG2 . THR A 1 331 ? 126.459 134.699 127.206 1.00 59.46 ? 331 THR A CG2 1 
ATOM   2345 N  N   . PRO A 1 332 ? 127.778 138.265 127.762 1.00 59.47 ? 332 PRO A N   1 
ATOM   2346 C  CA  . PRO A 1 332 ? 127.424 139.193 128.847 1.00 59.47 ? 332 PRO A CA  1 
ATOM   2347 C  C   . PRO A 1 332 ? 126.694 140.443 128.391 1.00 59.47 ? 332 PRO A C   1 
ATOM   2348 O  O   . PRO A 1 332 ? 126.077 141.113 129.225 1.00 59.47 ? 332 PRO A O   1 
ATOM   2349 C  CB  . PRO A 1 332 ? 128.777 139.560 129.460 1.00 59.47 ? 332 PRO A CB  1 
ATOM   2350 C  CG  . PRO A 1 332 ? 129.637 138.466 129.126 1.00 59.47 ? 332 PRO A CG  1 
ATOM   2351 C  CD  . PRO A 1 332 ? 129.235 138.044 127.770 1.00 59.47 ? 332 PRO A CD  1 
ATOM   2352 N  N   . LEU A 1 333 ? 126.727 140.782 127.108 1.00 59.26 ? 333 LEU A N   1 
ATOM   2353 C  CA  . LEU A 1 333 ? 125.875 141.834 126.591 1.00 59.26 ? 333 LEU A CA  1 
ATOM   2354 C  C   . LEU A 1 333 ? 124.473 141.345 126.310 1.00 59.26 ? 333 LEU A C   1 
ATOM   2355 O  O   . LEU A 1 333 ? 123.533 142.141 126.371 1.00 59.26 ? 333 LEU A O   1 
ATOM   2356 C  CB  . LEU A 1 333 ? 126.464 142.419 125.315 1.00 59.26 ? 333 LEU A CB  1 
ATOM   2357 C  CG  . LEU A 1 333 ? 127.810 143.058 125.549 1.00 59.26 ? 333 LEU A CG  1 
ATOM   2358 C  CD1 . LEU A 1 333 ? 128.321 143.529 124.238 1.00 59.26 ? 333 LEU A CD1 1 
ATOM   2359 C  CD2 . LEU A 1 333 ? 127.647 144.198 126.505 1.00 59.26 ? 333 LEU A CD2 1 
ATOM   2360 N  N   . TYR A 1 334 ? 124.307 140.058 126.029 1.00 61.67 ? 334 TYR A N   1 
ATOM   2361 C  CA  . TYR A 1 334 ? 122.977 139.498 125.880 1.00 61.67 ? 334 TYR A CA  1 
ATOM   2362 C  C   . TYR A 1 334 ? 122.206 139.470 127.185 1.00 61.67 ? 334 TYR A C   1 
ATOM   2363 O  O   . TYR A 1 334 ? 120.988 139.314 127.145 1.00 61.67 ? 334 TYR A O   1 
ATOM   2364 C  CB  . TYR A 1 334 ? 123.037 138.077 125.324 1.00 61.67 ? 334 TYR A CB  1 
ATOM   2365 C  CG  . TYR A 1 334 ? 123.357 137.965 123.856 1.00 61.67 ? 334 TYR A CG  1 
ATOM   2366 C  CD1 . TYR A 1 334 ? 123.353 139.074 123.038 1.00 61.67 ? 334 TYR A CD1 1 
ATOM   2367 C  CD2 . TYR A 1 334 ? 123.585 136.730 123.275 1.00 61.67 ? 334 TYR A CD2 1 
ATOM   2368 C  CE1 . TYR A 1 334 ? 123.620 138.966 121.700 1.00 61.67 ? 334 TYR A CE1 1 
ATOM   2369 C  CE2 . TYR A 1 334 ? 123.853 136.617 121.932 1.00 61.67 ? 334 TYR A CE2 1 
ATOM   2370 C  CZ  . TYR A 1 334 ? 123.868 137.743 121.154 1.00 61.67 ? 334 TYR A CZ  1 
ATOM   2371 O  OH  . TYR A 1 334 ? 124.130 137.664 119.816 1.00 61.67 ? 334 TYR A OH  1 
ATOM   2372 N  N   . PHE A 1 335 ? 122.878 139.611 128.329 1.00 63.38 ? 335 PHE A N   1 
ATOM   2373 C  CA  . PHE A 1 335 ? 122.246 139.599 129.641 1.00 63.38 ? 335 PHE A CA  1 
ATOM   2374 C  C   . PHE A 1 335 ? 121.972 140.984 130.193 1.00 63.38 ? 335 PHE A C   1 
ATOM   2375 O  O   . PHE A 1 335 ? 120.864 141.231 130.675 1.00 63.38 ? 335 PHE A O   1 
ATOM   2376 C  CB  . PHE A 1 335 ? 123.108 138.830 130.645 1.00 63.38 ? 335 PHE A CB  1 
ATOM   2377 C  CG  . PHE A 1 335 ? 122.972 137.354 130.541 1.00 63.38 ? 335 PHE A CG  1 
ATOM   2378 C  CD1 . PHE A 1 335 ? 121.899 136.716 131.129 1.00 63.38 ? 335 PHE A CD1 1 
ATOM   2379 C  CD2 . PHE A 1 335 ? 123.900 136.602 129.857 1.00 63.38 ? 335 PHE A CD2 1 
ATOM   2380 C  CE1 . PHE A 1 335 ? 121.755 135.353 131.039 1.00 63.38 ? 335 PHE A CE1 1 
ATOM   2381 C  CE2 . PHE A 1 335 ? 123.765 135.242 129.766 1.00 63.38 ? 335 PHE A CE2 1 
ATOM   2382 C  CZ  . PHE A 1 335 ? 122.691 134.616 130.363 1.00 63.38 ? 335 PHE A CZ  1 
ATOM   2383 N  N   . VAL A 1 336 ? 122.960 141.884 130.161 1.00 62.31 ? 336 VAL A N   1 
ATOM   2384 C  CA  . VAL A 1 336 ? 122.788 143.197 130.775 1.00 62.31 ? 336 VAL A CA  1 
ATOM   2385 C  C   . VAL A 1 336 ? 121.771 144.025 129.997 1.00 62.31 ? 336 VAL A C   1 
ATOM   2386 O  O   . VAL A 1 336 ? 120.969 144.752 130.594 1.00 62.31 ? 336 VAL A O   1 
ATOM   2387 C  CB  . VAL A 1 336 ? 124.153 143.894 130.897 1.00 62.31 ? 336 VAL A CB  1 
ATOM   2388 C  CG1 . VAL A 1 336 ? 124.015 145.278 131.493 1.00 62.31 ? 336 VAL A CG1 1 
ATOM   2389 C  CG2 . VAL A 1 336 ? 125.064 143.059 131.754 1.00 62.31 ? 336 VAL A CG2 1 
ATOM   2390 N  N   . TRP A 1 337 ? 121.748 143.888 128.667 1.00 62.27 ? 337 TRP A N   1 
ATOM   2391 C  CA  . TRP A 1 337 ? 120.642 144.419 127.879 1.00 62.27 ? 337 TRP A CA  1 
ATOM   2392 C  C   . TRP A 1 337 ? 119.318 143.787 128.268 1.00 62.27 ? 337 TRP A C   1 
ATOM   2393 O  O   . TRP A 1 337 ? 118.287 144.459 128.257 1.00 62.27 ? 337 TRP A O   1 
ATOM   2394 C  CB  . TRP A 1 337 ? 120.882 144.195 126.388 1.00 62.27 ? 337 TRP A CB  1 
ATOM   2395 C  CG  . TRP A 1 337 ? 119.725 144.631 125.550 1.00 62.27 ? 337 TRP A CG  1 
ATOM   2396 C  CD1 . TRP A 1 337 ? 118.788 143.835 124.977 1.00 62.27 ? 337 TRP A CD1 1 
ATOM   2397 C  CD2 . TRP A 1 337 ? 119.362 145.970 125.226 1.00 62.27 ? 337 TRP A CD2 1 
ATOM   2398 N  NE1 . TRP A 1 337 ? 117.870 144.592 124.302 1.00 62.27 ? 337 TRP A NE1 1 
ATOM   2399 C  CE2 . TRP A 1 337 ? 118.205 145.909 124.437 1.00 62.27 ? 337 TRP A CE2 1 
ATOM   2400 C  CE3 . TRP A 1 337 ? 119.915 147.216 125.511 1.00 62.27 ? 337 TRP A CE3 1 
ATOM   2401 C  CZ2 . TRP A 1 337 ? 117.586 147.041 123.942 1.00 62.27 ? 337 TRP A CZ2 1 
ATOM   2402 C  CZ3 . TRP A 1 337 ? 119.299 148.342 125.015 1.00 62.27 ? 337 TRP A CZ3 1 
ATOM   2403 C  CH2 . TRP A 1 337 ? 118.147 148.247 124.238 1.00 62.27 ? 337 TRP A CH2 1 
ATOM   2404 N  N   . GLU A 1 338 ? 119.326 142.516 128.649 1.00 70.64 ? 338 GLU A N   1 
ATOM   2405 C  CA  . GLU A 1 338 ? 118.072 141.812 128.839 1.00 70.64 ? 338 GLU A CA  1 
ATOM   2406 C  C   . GLU A 1 338 ? 117.495 142.039 130.230 1.00 70.64 ? 338 GLU A C   1 
ATOM   2407 O  O   . GLU A 1 338 ? 116.416 141.525 130.540 1.00 70.64 ? 338 GLU A O   1 
ATOM   2408 C  CB  . GLU A 1 338 ? 118.287 140.335 128.542 1.00 70.64 ? 338 GLU A CB  1 
ATOM   2409 C  CG  . GLU A 1 338 ? 117.072 139.635 128.026 1.00 70.64 ? 338 GLU A CG  1 
ATOM   2410 C  CD  . GLU A 1 338 ? 117.391 138.284 127.477 1.00 70.64 ? 338 GLU A CD  1 
ATOM   2411 O  OE1 . GLU A 1 338 ? 118.556 137.863 127.572 1.00 70.64 ? 338 GLU A OE1 1 
ATOM   2412 O  OE2 . GLU A 1 338 ? 116.481 137.650 126.919 1.00 70.64 ? 338 GLU A OE2 1 
ATOM   2413 N  N   . LYS A 1 339 ? 118.189 142.797 131.080 1.00 71.05 ? 339 LYS A N   1 
ATOM   2414 C  CA  . LYS A 1 339 ? 117.584 143.217 132.336 1.00 71.05 ? 339 LYS A CA  1 
ATOM   2415 C  C   . LYS A 1 339 ? 116.914 144.576 132.194 1.00 71.05 ? 339 LYS A C   1 
ATOM   2416 O  O   . LYS A 1 339 ? 115.942 144.867 132.898 1.00 71.05 ? 339 LYS A O   1 
ATOM   2417 C  CB  . LYS A 1 339 ? 118.630 143.253 133.448 1.00 71.05 ? 339 LYS A CB  1 
ATOM   2418 C  CG  . LYS A 1 339 ? 119.420 141.958 133.679 1.00 71.05 ? 339 LYS A CG  1 
ATOM   2419 C  CD  . LYS A 1 339 ? 118.599 140.809 134.245 1.00 71.05 ? 339 LYS A CD  1 
ATOM   2420 C  CE  . LYS A 1 339 ? 118.265 139.763 133.189 1.00 71.05 ? 339 LYS A CE  1 
ATOM   2421 N  NZ  . LYS A 1 339 ? 117.576 138.607 133.792 1.00 71.05 ? 339 LYS A NZ  1 
ATOM   2422 N  N   . VAL A 1 340 ? 117.432 145.432 131.306 1.00 70.87 ? 340 VAL A N   1 
ATOM   2423 C  CA  . VAL A 1 340 ? 116.792 146.719 131.053 1.00 70.87 ? 340 VAL A CA  1 
ATOM   2424 C  C   . VAL A 1 340 ? 115.450 146.536 130.369 1.00 70.87 ? 340 VAL A C   1 
ATOM   2425 O  O   . VAL A 1 340 ? 114.430 147.008 130.884 1.00 70.87 ? 340 VAL A O   1 
ATOM   2426 C  CB  . VAL A 1 340 ? 117.707 147.637 130.224 1.00 70.87 ? 340 VAL A CB  1 
ATOM   2427 C  CG1 . VAL A 1 340 ? 116.962 148.884 129.805 1.00 70.87 ? 340 VAL A CG1 1 
ATOM   2428 C  CG2 . VAL A 1 340 ? 118.927 148.016 131.030 1.00 70.87 ? 340 VAL A CG2 1 
ATOM   2429 N  N   . ILE A 1 341 ? 115.413 145.843 129.240 1.00 73.52 ? 341 ILE A N   1 
ATOM   2430 C  CA  . ILE A 1 341 ? 114.181 145.333 128.709 1.00 73.52 ? 341 ILE A CA  1 
ATOM   2431 C  C   . ILE A 1 341 ? 113.661 144.309 129.711 1.00 73.52 ? 341 ILE A C   1 
ATOM   2432 O  O   . ILE A 1 341 ? 114.423 143.589 130.350 1.00 73.52 ? 341 ILE A O   1 
ATOM   2433 C  CB  . ILE A 1 341 ? 114.368 144.760 127.275 1.00 73.52 ? 341 ILE A CB  1 
ATOM   2434 C  CG1 . ILE A 1 341 ? 113.043 144.361 126.629 1.00 73.52 ? 341 ILE A CG1 1 
ATOM   2435 C  CG2 . ILE A 1 341 ? 115.298 143.600 127.250 1.00 73.52 ? 341 ILE A CG2 1 
ATOM   2436 C  CD1 . ILE A 1 341 ? 113.169 144.022 125.141 1.00 73.52 ? 341 ILE A CD1 1 
ATOM   2437 N  N   . GLY A 1 342 ? 112.352 144.295 129.917 1.00 81.72 ? 342 GLY A N   1 
ATOM   2438 C  CA  . GLY A 1 342 ? 111.818 143.535 131.030 1.00 81.72 ? 342 GLY A CA  1 
ATOM   2439 C  C   . GLY A 1 342 ? 111.554 142.079 130.729 1.00 81.72 ? 342 GLY A C   1 
ATOM   2440 O  O   . GLY A 1 342 ? 110.450 141.587 130.971 1.00 81.72 ? 342 GLY A O   1 
ATOM   2441 N  N   . MET A 1 343 ? 112.562 141.372 130.224 1.00 87.18 ? 343 MET A N   1 
ATOM   2442 C  CA  . MET A 1 343 ? 112.379 140.009 129.730 1.00 87.18 ? 343 MET A CA  1 
ATOM   2443 C  C   . MET A 1 343 ? 113.383 139.107 130.438 1.00 87.18 ? 343 MET A C   1 
ATOM   2444 O  O   . MET A 1 343 ? 114.503 138.911 129.961 1.00 87.18 ? 343 MET A O   1 
ATOM   2445 C  CB  . MET A 1 343 ? 112.539 139.948 128.218 1.00 87.18 ? 343 MET A CB  1 
ATOM   2446 C  CG  . MET A 1 343 ? 112.186 138.612 127.648 1.00 87.18 ? 343 MET A CG  1 
ATOM   2447 S  SD  . MET A 1 343 ? 110.499 138.202 128.117 1.00 87.18 ? 343 MET A SD  1 
ATOM   2448 C  CE  . MET A 1 343 ? 109.586 139.439 127.195 1.00 87.18 ? 343 MET A CE  1 
ATOM   2449 N  N   . HIS A 1 344 ? 112.968 138.555 131.575 1.00 91.69 ? 344 HIS A N   1 
ATOM   2450 C  CA  . HIS A 1 344 ? 113.823 137.667 132.352 1.00 91.69 ? 344 HIS A CA  1 
ATOM   2451 C  C   . HIS A 1 344 ? 113.815 136.259 131.767 1.00 91.69 ? 344 HIS A C   1 
ATOM   2452 O  O   . HIS A 1 344 ? 114.845 135.758 131.303 1.00 91.69 ? 344 HIS A O   1 
ATOM   2453 C  CB  . HIS A 1 344 ? 113.347 137.669 133.810 1.00 91.69 ? 344 HIS A CB  1 
ATOM   2454 C  CG  . HIS A 1 344 ? 114.234 136.923 134.762 1.00 91.69 ? 344 HIS A CG  1 
ATOM   2455 N  ND1 . HIS A 1 344 ? 113.854 136.649 136.059 1.00 91.69 ? 344 HIS A ND1 1 
ATOM   2456 C  CD2 . HIS A 1 344 ? 115.472 136.396 134.615 1.00 91.69 ? 344 HIS A CD2 1 
ATOM   2457 C  CE1 . HIS A 1 344 ? 114.821 135.987 136.669 1.00 91.69 ? 344 HIS A CE1 1 
ATOM   2458 N  NE2 . HIS A 1 344 ? 115.814 135.821 135.815 1.00 91.69 ? 344 HIS A NE2 1 
ATOM   2459 N  N   . ASP A 1 345 ? 112.695 135.581 131.837 1.00 88.98 ? 345 ASP A N   1 
ATOM   2460 C  CA  . ASP A 1 345 ? 112.669 134.273 131.288 1.00 88.98 ? 345 ASP A CA  1 
ATOM   2461 C  C   . ASP A 1 345 ? 111.754 134.310 130.135 1.00 88.98 ? 345 ASP A C   1 
ATOM   2462 O  O   . ASP A 1 345 ? 110.635 134.818 130.232 1.00 88.98 ? 345 ASP A O   1 
ATOM   2463 C  CB  . ASP A 1 345 ? 112.154 133.302 132.316 1.00 88.98 ? 345 ASP A CB  1 
ATOM   2464 C  CG  . ASP A 1 345 ? 112.340 131.870 131.901 1.00 88.98 ? 345 ASP A CG  1 
ATOM   2465 O  OD1 . ASP A 1 345 ? 113.238 131.602 131.076 1.00 88.98 ? 345 ASP A OD1 1 
ATOM   2466 O  OD2 . ASP A 1 345 ? 111.585 131.009 132.398 1.00 88.98 ? 345 ASP A OD2 1 
ATOM   2467 N  N   . THR A 1 346 ? 112.228 133.831 129.008 1.00 87.46 ? 346 THR A N   1 
ATOM   2468 C  CA  . THR A 1 346 ? 111.368 133.703 127.860 1.00 87.46 ? 346 THR A CA  1 
ATOM   2469 C  C   . THR A 1 346 ? 110.817 132.344 128.028 1.00 87.46 ? 346 THR A C   1 
ATOM   2470 O  O   . THR A 1 346 ? 111.125 131.649 128.988 1.00 87.46 ? 346 THR A O   1 
ATOM   2471 C  CB  . THR A 1 346 ? 112.142 133.682 126.574 1.00 87.46 ? 346 THR A CB  1 
ATOM   2472 O  OG1 . THR A 1 346 ? 111.236 133.848 125.496 1.00 87.46 ? 346 THR A OG1 1 
ATOM   2473 C  CG2 . THR A 1 346 ? 112.858 132.341 126.426 1.00 87.46 ? 346 THR A CG2 1 
ATOM   2474 N  N   . LYS A 1 347 ? 109.971 131.916 127.140 1.00 93.52 ? 347 LYS A N   1 
ATOM   2475 C  CA  . LYS A 1 347 ? 109.430 130.626 127.392 1.00 93.52 ? 347 LYS A CA  1 
ATOM   2476 C  C   . LYS A 1 347 ? 109.703 129.755 126.184 1.00 93.52 ? 347 LYS A C   1 
ATOM   2477 O  O   . LYS A 1 347 ? 110.165 128.625 126.328 1.00 93.52 ? 347 LYS A O   1 
ATOM   2478 C  CB  . LYS A 1 347 ? 107.942 130.752 127.707 1.00 93.52 ? 347 LYS A CB  1 
ATOM   2479 C  CG  . LYS A 1 347 ? 107.609 131.383 129.039 1.00 93.52 ? 347 LYS A CG  1 
ATOM   2480 C  CD  . LYS A 1 347 ? 106.271 132.092 128.945 1.00 93.52 ? 347 LYS A CD  1 
ATOM   2481 C  CE  . LYS A 1 347 ? 106.042 132.658 127.552 1.00 93.52 ? 347 LYS A CE  1 
ATOM   2482 N  NZ  . LYS A 1 347 ? 104.703 133.289 127.420 1.00 93.52 ? 347 LYS A NZ  1 
ATOM   2483 N  N   . SER A 1 348 ? 109.438 130.281 124.994 1.00 90.33 ? 348 SER A N   1 
ATOM   2484 C  CA  . SER A 1 348 ? 109.602 129.503 123.775 1.00 90.33 ? 348 SER A CA  1 
ATOM   2485 C  C   . SER A 1 348 ? 110.838 130.035 123.147 1.00 90.33 ? 348 SER A C   1 
ATOM   2486 O  O   . SER A 1 348 ? 111.596 130.782 123.755 1.00 90.33 ? 348 SER A O   1 
ATOM   2487 C  CB  . SER A 1 348 ? 108.597 129.961 122.731 1.00 90.33 ? 348 SER A CB  1 
ATOM   2488 O  OG  . SER A 1 348 ? 108.831 131.307 122.345 1.00 90.33 ? 348 SER A OG  1 
ATOM   2489 N  N   . ILE A 1 349 ? 111.100 129.603 121.933 1.00 86.63 ? 349 ILE A N   1 
ATOM   2490 C  CA  . ILE A 1 349 ? 112.438 129.918 121.465 1.00 86.63 ? 349 ILE A CA  1 
ATOM   2491 C  C   . ILE A 1 349 ? 112.482 131.223 120.680 1.00 86.63 ? 349 ILE A C   1 
ATOM   2492 O  O   . ILE A 1 349 ? 113.503 131.917 120.704 1.00 86.63 ? 349 ILE A O   1 
ATOM   2493 C  CB  . ILE A 1 349 ? 112.991 128.725 120.657 1.00 86.63 ? 349 ILE A CB  1 
ATOM   2494 C  CG1 . ILE A 1 349 ? 112.073 128.355 119.484 1.00 86.63 ? 349 ILE A CG1 1 
ATOM   2495 C  CG2 . ILE A 1 349 ? 113.201 127.513 121.567 1.00 86.63 ? 349 ILE A CG2 1 
ATOM   2496 C  CD1 . ILE A 1 349 ? 112.681 127.331 118.534 1.00 86.63 ? 349 ILE A CD1 1 
ATOM   2497 N  N   . CYS A 1 350 ? 111.393 131.598 120.013 1.00 85.99 ? 350 CYS A N   1 
ATOM   2498 C  CA  . CYS A 1 350 ? 111.369 132.808 119.200 1.00 85.99 ? 350 CYS A CA  1 
ATOM   2499 C  C   . CYS A 1 350 ? 111.142 134.072 120.018 1.00 85.99 ? 350 CYS A C   1 
ATOM   2500 O  O   . CYS A 1 350 ? 111.230 135.179 119.478 1.00 85.99 ? 350 CYS A O   1 
ATOM   2501 C  CB  . CYS A 1 350 ? 110.288 132.698 118.117 1.00 85.99 ? 350 CYS A CB  1 
ATOM   2502 S  SG  . CYS A 1 350 ? 108.582 132.618 118.724 1.00 85.99 ? 350 CYS A SG  1 
ATOM   2503 N  N   . LEU A 1 351 ? 110.831 133.934 121.301 1.00 79.08 ? 351 LEU A N   1 
ATOM   2504 C  CA  . LEU A 1 351 ? 110.673 135.104 122.150 1.00 79.08 ? 351 LEU A CA  1 
ATOM   2505 C  C   . LEU A 1 351 ? 112.039 135.502 122.693 1.00 79.08 ? 351 LEU A C   1 
ATOM   2506 O  O   . LEU A 1 351 ? 112.385 136.689 122.708 1.00 79.08 ? 351 LEU A O   1 
ATOM   2507 C  CB  . LEU A 1 351 ? 109.624 134.812 123.212 1.00 79.08 ? 351 LEU A CB  1 
ATOM   2508 C  CG  . LEU A 1 351 ? 108.310 134.295 122.639 1.00 79.08 ? 351 LEU A CG  1 
ATOM   2509 C  CD1 . LEU A 1 351 ? 107.362 133.929 123.763 1.00 79.08 ? 351 LEU A CD1 1 
ATOM   2510 C  CD2 . LEU A 1 351 ? 107.687 135.306 121.698 1.00 79.08 ? 351 LEU A CD2 1 
ATOM   2511 N  N   . ARG A 1 352 ? 112.818 134.523 123.154 1.00 76.29 ? 352 ARG A N   1 
ATOM   2512 C  CA  . ARG A 1 352 ? 114.189 134.782 123.570 1.00 76.29 ? 352 ARG A CA  1 
ATOM   2513 C  C   . ARG A 1 352 ? 115.059 135.383 122.477 1.00 76.29 ? 352 ARG A C   1 
ATOM   2514 O  O   . ARG A 1 352 ? 115.880 136.268 122.741 1.00 76.29 ? 352 ARG A O   1 
ATOM   2515 C  CB  . ARG A 1 352 ? 114.810 133.499 124.121 1.00 76.29 ? 352 ARG A CB  1 
ATOM   2516 C  CG  . ARG A 1 352 ? 116.235 133.636 124.595 1.00 76.29 ? 352 ARG A CG  1 
ATOM   2517 C  CD  . ARG A 1 352 ? 116.329 134.632 125.713 1.00 76.29 ? 352 ARG A CD  1 
ATOM   2518 N  NE  . ARG A 1 352 ? 115.656 134.211 126.926 1.00 76.29 ? 352 ARG A NE  1 
ATOM   2519 C  CZ  . ARG A 1 352 ? 116.244 133.500 127.877 1.00 76.29 ? 352 ARG A CZ  1 
ATOM   2520 N  NH1 . ARG A 1 352 ? 115.566 133.151 128.960 1.00 76.29 ? 352 ARG A NH1 1 
ATOM   2521 N  NH2 . ARG A 1 352 ? 117.513 133.144 127.745 1.00 76.29 ? 352 ARG A NH2 1 
ATOM   2522 N  N   . ALA A 1 353 ? 114.879 134.936 121.236 1.00 74.91 ? 353 ALA A N   1 
ATOM   2523 C  CA  . ALA A 1 353 ? 115.673 135.487 120.144 1.00 74.91 ? 353 ALA A CA  1 
ATOM   2524 C  C   . ALA A 1 353 ? 115.264 136.911 119.800 1.00 74.91 ? 353 ALA A C   1 
ATOM   2525 O  O   . ALA A 1 353 ? 116.068 137.669 119.254 1.00 74.91 ? 353 ALA A O   1 
ATOM   2526 C  CB  . ALA A 1 353 ? 115.557 134.599 118.907 1.00 74.91 ? 353 ALA A CB  1 
ATOM   2527 N  N   . LEU A 1 354 ? 114.032 137.300 120.123 1.00 72.69 ? 354 LEU A N   1 
ATOM   2528 C  CA  . LEU A 1 354 ? 113.535 138.589 119.667 1.00 72.69 ? 354 LEU A CA  1 
ATOM   2529 C  C   . LEU A 1 354 ? 114.182 139.721 120.445 1.00 72.69 ? 354 LEU A C   1 
ATOM   2530 O  O   . LEU A 1 354 ? 114.397 140.805 119.897 1.00 72.69 ? 354 LEU A O   1 
ATOM   2531 C  CB  . LEU A 1 354 ? 112.012 138.621 119.802 1.00 72.69 ? 354 LEU A CB  1 
ATOM   2532 C  CG  . LEU A 1 354 ? 111.232 139.891 119.455 1.00 72.69 ? 354 LEU A CG  1 
ATOM   2533 C  CD1 . LEU A 1 354 ? 111.327 140.328 118.004 1.00 72.69 ? 354 LEU A CD1 1 
ATOM   2534 C  CD2 . LEU A 1 354 ? 109.783 139.698 119.862 1.00 72.69 ? 354 LEU A CD2 1 
ATOM   2535 N  N   . ALA A 1 355 ? 114.566 139.456 121.692 1.00 69.89 ? 355 ALA A N   1 
ATOM   2536 C  CA  . ALA A 1 355 ? 115.061 140.488 122.595 1.00 69.89 ? 355 ALA A CA  1 
ATOM   2537 C  C   . ALA A 1 355 ? 116.382 141.006 122.043 1.00 69.89 ? 355 ALA A C   1 
ATOM   2538 O  O   . ALA A 1 355 ? 116.672 142.200 122.162 1.00 69.89 ? 355 ALA A O   1 
ATOM   2539 C  CB  . ALA A 1 355 ? 115.053 139.962 124.033 1.00 69.89 ? 355 ALA A CB  1 
ATOM   2540 N  N   . ARG A 1 356 ? 117.188 140.139 121.441 1.00 65.67 ? 356 ARG A N   1 
ATOM   2541 C  CA  . ARG A 1 356 ? 118.587 140.440 121.192 1.00 65.67 ? 356 ARG A CA  1 
ATOM   2542 C  C   . ARG A 1 356 ? 118.982 141.025 119.846 1.00 65.67 ? 356 ARG A C   1 
ATOM   2543 O  O   . ARG A 1 356 ? 120.149 141.373 119.651 1.00 65.67 ? 356 ARG A O   1 
ATOM   2544 C  CB  . ARG A 1 356 ? 119.276 139.117 121.495 1.00 65.67 ? 356 ARG A CB  1 
ATOM   2545 C  CG  . ARG A 1 356 ? 119.089 138.628 122.913 1.00 65.67 ? 356 ARG A CG  1 
ATOM   2546 C  CD  . ARG A 1 356 ? 120.079 137.528 123.172 1.00 65.67 ? 356 ARG A CD  1 
ATOM   2547 N  NE  . ARG A 1 356 ? 119.770 136.263 122.535 1.00 65.67 ? 356 ARG A NE  1 
ATOM   2548 C  CZ  . ARG A 1 356 ? 119.388 135.197 123.219 1.00 65.67 ? 356 ARG A CZ  1 
ATOM   2549 N  NH1 . ARG A 1 356 ? 119.350 135.257 124.540 1.00 65.67 ? 356 ARG A NH1 1 
ATOM   2550 N  NH2 . ARG A 1 356 ? 119.109 134.061 122.601 1.00 65.67 ? 356 ARG A NH2 1 
ATOM   2551 N  N   . LEU A 1 357 ? 118.055 141.108 118.904 1.00 60.92 ? 357 LEU A N   1 
ATOM   2552 C  CA  . LEU A 1 357 ? 118.372 141.777 117.644 1.00 60.92 ? 357 LEU A CA  1 
ATOM   2553 C  C   . LEU A 1 357 ? 118.874 143.217 117.733 1.00 60.92 ? 357 LEU A C   1 
ATOM   2554 O  O   . LEU A 1 357 ? 119.844 143.527 117.026 1.00 60.92 ? 357 LEU A O   1 
ATOM   2555 C  CB  . LEU A 1 357 ? 117.203 141.627 116.666 1.00 60.92 ? 357 LEU A CB  1 
ATOM   2556 C  CG  . LEU A 1 357 ? 116.931 140.175 116.264 1.00 60.92 ? 357 LEU A CG  1 
ATOM   2557 C  CD1 . LEU A 1 357 ? 115.682 140.030 115.412 1.00 60.92 ? 357 LEU A CD1 1 
ATOM   2558 C  CD2 . LEU A 1 357 ? 118.119 139.595 115.534 1.00 60.92 ? 357 LEU A CD2 1 
ATOM   2559 N  N   . PRO A 1 358 ? 118.338 144.128 118.559 1.00 56.16 ? 358 PRO A N   1 
ATOM   2560 C  CA  . PRO A 1 358 ? 118.968 145.451 118.666 1.00 56.16 ? 358 PRO A CA  1 
ATOM   2561 C  C   . PRO A 1 358 ? 120.239 145.511 119.496 1.00 56.16 ? 358 PRO A C   1 
ATOM   2562 O  O   . PRO A 1 358 ? 120.675 146.610 119.833 1.00 56.16 ? 358 PRO A O   1 
ATOM   2563 C  CB  . PRO A 1 358 ? 117.872 146.311 119.306 1.00 56.16 ? 358 PRO A CB  1 
ATOM   2564 C  CG  . PRO A 1 358 ? 117.043 145.402 120.001 1.00 56.16 ? 358 PRO A CG  1 
ATOM   2565 C  CD  . PRO A 1 358 ? 116.993 144.188 119.169 1.00 56.16 ? 358 PRO A CD  1 
ATOM   2566 N  N   . VAL A 1 359 ? 120.865 144.393 119.835 1.00 56.66 ? 359 VAL A N   1 
ATOM   2567 C  CA  . VAL A 1 359 ? 122.225 144.402 120.358 1.00 56.66 ? 359 VAL A CA  1 
ATOM   2568 C  C   . VAL A 1 359 ? 123.204 143.715 119.410 1.00 56.66 ? 359 VAL A C   1 
ATOM   2569 O  O   . VAL A 1 359 ? 124.422 143.831 119.605 1.00 56.66 ? 359 VAL A O   1 
ATOM   2570 C  CB  . VAL A 1 359 ? 122.278 143.767 121.769 1.00 56.66 ? 359 VAL A CB  1 
ATOM   2571 C  CG1 . VAL A 1 359 ? 122.227 142.278 121.694 1.00 56.66 ? 359 VAL A CG1 1 
ATOM   2572 C  CG2 . VAL A 1 359 ? 123.444 144.273 122.621 1.00 56.66 ? 359 VAL A CG2 1 
ATOM   2573 N  N   . VAL A 1 360 ? 122.718 143.053 118.354 1.00 54.98 ? 360 VAL A N   1 
ATOM   2574 C  CA  . VAL A 1 360 ? 123.579 142.411 117.364 1.00 54.98 ? 360 VAL A CA  1 
ATOM   2575 C  C   . VAL A 1 360 ? 123.661 143.196 116.052 1.00 54.98 ? 360 VAL A C   1 
ATOM   2576 O  O   . VAL A 1 360 ? 124.590 142.962 115.266 1.00 54.98 ? 360 VAL A O   1 
ATOM   2577 C  CB  . VAL A 1 360 ? 123.108 140.962 117.099 1.00 54.98 ? 360 VAL A CB  1 
ATOM   2578 C  CG1 . VAL A 1 360 ? 121.874 140.951 116.229 1.00 54.98 ? 360 VAL A CG1 1 
ATOM   2579 C  CG2 . VAL A 1 360 ? 124.222 140.060 116.547 1.00 54.98 ? 360 VAL A CG2 1 
ATOM   2580 N  N   . ILE A 1 361 ? 122.753 144.135 115.804 1.00 49.50 ? 361 ILE A N   1 
ATOM   2581 C  CA  . ILE A 1 361 ? 122.813 144.949 114.590 1.00 49.50 ? 361 ILE A CA  1 
ATOM   2582 C  C   . ILE A 1 361 ? 123.988 145.931 114.631 1.00 49.50 ? 361 ILE A C   1 
ATOM   2583 O  O   . ILE A 1 361 ? 124.709 146.001 113.630 1.00 49.50 ? 361 ILE A O   1 
ATOM   2584 C  CB  . ILE A 1 361 ? 121.467 145.642 114.316 1.00 49.50 ? 361 ILE A CB  1 
ATOM   2585 C  CG1 . ILE A 1 361 ? 120.398 144.605 114.019 1.00 49.50 ? 361 ILE A CG1 1 
ATOM   2586 C  CG2 . ILE A 1 361 ? 121.561 146.569 113.137 1.00 49.50 ? 361 ILE A CG2 1 
ATOM   2587 C  CD1 . ILE A 1 361 ? 119.006 145.171 114.006 1.00 49.50 ? 361 ILE A CD1 1 
ATOM   2588 N  N   . PRO A 1 362 ? 124.296 146.664 115.719 1.00 48.97 ? 362 PRO A N   1 
ATOM   2589 C  CA  . PRO A 1 362 ? 125.545 147.439 115.684 1.00 48.97 ? 362 PRO A CA  1 
ATOM   2590 C  C   . PRO A 1 362 ? 126.807 146.602 115.775 1.00 48.97 ? 362 PRO A C   1 
ATOM   2591 O  O   . PRO A 1 362 ? 127.897 147.143 115.577 1.00 48.97 ? 362 PRO A O   1 
ATOM   2592 C  CB  . PRO A 1 362 ? 125.419 148.377 116.887 1.00 48.97 ? 362 PRO A CB  1 
ATOM   2593 C  CG  . PRO A 1 362 ? 124.033 148.468 117.139 1.00 48.97 ? 362 PRO A CG  1 
ATOM   2594 C  CD  . PRO A 1 362 ? 123.490 147.118 116.866 1.00 48.97 ? 362 PRO A CD  1 
ATOM   2595 N  N   . ILE A 1 363 ? 126.721 145.314 116.094 1.00 48.97 ? 363 ILE A N   1 
ATOM   2596 C  CA  . ILE A 1 363 ? 127.901 144.471 115.950 1.00 48.97 ? 363 ILE A CA  1 
ATOM   2597 C  C   . ILE A 1 363 ? 128.154 144.185 114.482 1.00 48.97 ? 363 ILE A C   1 
ATOM   2598 O  O   . ILE A 1 363 ? 129.283 144.282 113.996 1.00 48.97 ? 363 ILE A O   1 
ATOM   2599 C  CB  . ILE A 1 363 ? 127.747 143.183 116.774 1.00 48.97 ? 363 ILE A CB  1 
ATOM   2600 C  CG1 . ILE A 1 363 ? 127.759 143.521 118.258 1.00 48.97 ? 363 ILE A CG1 1 
ATOM   2601 C  CG2 . ILE A 1 363 ? 128.855 142.224 116.486 1.00 48.97 ? 363 ILE A CG2 1 
ATOM   2602 C  CD1 . ILE A 1 363 ? 127.446 142.368 119.138 1.00 48.97 ? 363 ILE A CD1 1 
ATOM   2603 N  N   . TRP A 1 364 ? 127.098 143.883 113.743 1.00 49.01 ? 364 TRP A N   1 
ATOM   2604 C  CA  . TRP A 1 364 ? 127.204 143.558 112.332 1.00 49.01 ? 364 TRP A CA  1 
ATOM   2605 C  C   . TRP A 1 364 ? 127.356 144.789 111.454 1.00 49.01 ? 364 TRP A C   1 
ATOM   2606 O  O   . TRP A 1 364 ? 127.854 144.668 110.333 1.00 49.01 ? 364 TRP A O   1 
ATOM   2607 C  CB  . TRP A 1 364 ? 125.976 142.737 111.946 1.00 49.01 ? 364 TRP A CB  1 
ATOM   2608 C  CG  . TRP A 1 364 ? 125.847 142.442 110.526 1.00 49.01 ? 364 TRP A CG  1 
ATOM   2609 C  CD1 . TRP A 1 364 ? 126.733 141.787 109.753 1.00 49.01 ? 364 TRP A CD1 1 
ATOM   2610 C  CD2 . TRP A 1 364 ? 124.746 142.780 109.686 1.00 49.01 ? 364 TRP A CD2 1 
ATOM   2611 N  NE1 . TRP A 1 364 ? 126.270 141.700 108.467 1.00 49.01 ? 364 TRP A NE1 1 
ATOM   2612 C  CE2 . TRP A 1 364 ? 125.042 142.300 108.403 1.00 49.01 ? 364 TRP A CE2 1 
ATOM   2613 C  CE3 . TRP A 1 364 ? 123.536 143.446 109.896 1.00 49.01 ? 364 TRP A CE3 1 
ATOM   2614 C  CZ2 . TRP A 1 364 ? 124.176 142.467 107.326 1.00 49.01 ? 364 TRP A CZ2 1 
ATOM   2615 C  CZ3 . TRP A 1 364 ? 122.676 143.612 108.828 1.00 49.01 ? 364 TRP A CZ3 1 
ATOM   2616 C  CH2 . TRP A 1 364 ? 122.999 143.124 107.559 1.00 49.01 ? 364 TRP A CH2 1 
ATOM   2617 N  N   . PHE A 1 365 ? 126.964 145.965 111.937 1.00 47.95 ? 365 PHE A N   1 
ATOM   2618 C  CA  . PHE A 1 365 ? 127.037 147.199 111.161 1.00 47.95 ? 365 PHE A CA  1 
ATOM   2619 C  C   . PHE A 1 365 ? 128.353 147.941 111.306 1.00 47.95 ? 365 PHE A C   1 
ATOM   2620 O  O   . PHE A 1 365 ? 128.856 148.474 110.320 1.00 47.95 ? 365 PHE A O   1 
ATOM   2621 C  CB  . PHE A 1 365 ? 125.895 148.137 111.565 1.00 47.95 ? 365 PHE A CB  1 
ATOM   2622 C  CG  . PHE A 1 365 ? 125.930 149.465 110.905 1.00 47.95 ? 365 PHE A CG  1 
ATOM   2623 C  CD1 . PHE A 1 365 ? 125.542 149.605 109.596 1.00 47.95 ? 365 PHE A CD1 1 
ATOM   2624 C  CD2 . PHE A 1 365 ? 126.321 150.585 111.612 1.00 47.95 ? 365 PHE A CD2 1 
ATOM   2625 C  CE1 . PHE A 1 365 ? 125.564 150.835 108.996 1.00 47.95 ? 365 PHE A CE1 1 
ATOM   2626 C  CE2 . PHE A 1 365 ? 126.343 151.808 111.025 1.00 47.95 ? 365 PHE A CE2 1 
ATOM   2627 C  CZ  . PHE A 1 365 ? 125.966 151.941 109.714 1.00 47.95 ? 365 PHE A CZ  1 
ATOM   2628 N  N   . LEU A 1 366 ? 128.929 147.983 112.497 1.00 46.39 ? 366 LEU A N   1 
ATOM   2629 C  CA  . LEU A 1 366 ? 130.188 148.674 112.710 1.00 46.39 ? 366 LEU A CA  1 
ATOM   2630 C  C   . LEU A 1 366 ? 131.368 147.941 112.128 1.00 46.39 ? 366 LEU A C   1 
ATOM   2631 O  O   . LEU A 1 366 ? 132.465 148.498 112.091 1.00 46.39 ? 366 LEU A O   1 
ATOM   2632 C  CB  . LEU A 1 366 ? 130.423 148.900 114.198 1.00 46.39 ? 366 LEU A CB  1 
ATOM   2633 C  CG  . LEU A 1 366 ? 129.509 149.890 114.889 1.00 46.39 ? 366 LEU A CG  1 
ATOM   2634 C  CD1 . LEU A 1 366 ? 129.765 149.837 116.367 1.00 46.39 ? 366 LEU A CD1 1 
ATOM   2635 C  CD2 . LEU A 1 366 ? 129.760 151.265 114.361 1.00 46.39 ? 366 LEU A CD2 1 
ATOM   2636 N  N   . ALA A 1 367 ? 131.193 146.705 111.687 1.00 49.01 ? 367 ALA A N   1 
ATOM   2637 C  CA  . ALA A 1 367 ? 132.212 146.020 110.921 1.00 49.01 ? 367 ALA A CA  1 
ATOM   2638 C  C   . ALA A 1 367 ? 132.063 146.228 109.424 1.00 49.01 ? 367 ALA A C   1 
ATOM   2639 O  O   . ALA A 1 367 ? 132.638 145.455 108.651 1.00 49.01 ? 367 ALA A O   1 
ATOM   2640 C  CB  . ALA A 1 367 ? 132.186 144.519 111.218 1.00 49.01 ? 367 ALA A CB  1 
ATOM   2641 N  N   . ILE A 1 368 ? 131.277 147.216 108.995 1.00 49.95 ? 368 ILE A N   1 
ATOM   2642 C  CA  . ILE A 1 368 ? 131.111 147.516 107.578 1.00 49.95 ? 368 ILE A CA  1 
ATOM   2643 C  C   . ILE A 1 368 ? 131.457 148.961 107.227 1.00 49.95 ? 368 ILE A C   1 
ATOM   2644 O  O   . ILE A 1 368 ? 132.033 149.188 106.148 1.00 49.95 ? 368 ILE A O   1 
ATOM   2645 C  CB  . ILE A 1 368 ? 129.694 147.121 107.096 1.00 49.95 ? 368 ILE A CB  1 
ATOM   2646 C  CG1 . ILE A 1 368 ? 129.629 145.607 106.922 1.00 49.95 ? 368 ILE A CG1 1 
ATOM   2647 C  CG2 . ILE A 1 368 ? 129.246 147.780 105.806 1.00 49.95 ? 368 ILE A CG2 1 
ATOM   2648 C  CD1 . ILE A 1 368 ? 128.258 145.086 106.655 1.00 49.95 ? 368 ILE A CD1 1 
ATOM   2649 N  N   . ILE A 1 369 ? 131.240 149.927 108.130 1.00 52.56 ? 369 ILE A N   1 
ATOM   2650 C  CA  . ILE A 1 369 ? 131.706 151.291 107.868 1.00 52.56 ? 369 ILE A CA  1 
ATOM   2651 C  C   . ILE A 1 369 ? 133.224 151.340 107.851 1.00 52.56 ? 369 ILE A C   1 
ATOM   2652 O  O   . ILE A 1 369 ? 133.840 151.799 106.883 1.00 52.56 ? 369 ILE A O   1 
ATOM   2653 C  CB  . ILE A 1 369 ? 131.162 152.300 108.894 1.00 52.56 ? 369 ILE A CB  1 
ATOM   2654 C  CG1 . ILE A 1 369 ? 129.667 152.505 108.772 1.00 52.56 ? 369 ILE A CG1 1 
ATOM   2655 C  CG2 . ILE A 1 369 ? 131.809 153.640 108.681 1.00 52.56 ? 369 ILE A CG2 1 
ATOM   2656 C  CD1 . ILE A 1 369 ? 129.162 153.516 109.771 1.00 52.56 ? 369 ILE A CD1 1 
ATOM   2657 N  N   . PHE A 1 370 ? 133.855 150.877 108.919 1.00 52.19 ? 370 PHE A N   1 
ATOM   2658 C  CA  . PHE A 1 370 ? 135.310 150.835 108.969 1.00 52.19 ? 370 PHE A CA  1 
ATOM   2659 C  C   . PHE A 1 370 ? 135.770 149.429 109.306 1.00 52.19 ? 370 PHE A C   1 
ATOM   2660 O  O   . PHE A 1 370 ? 135.743 149.004 110.465 1.00 52.19 ? 370 PHE A O   1 
ATOM   2661 C  CB  . PHE A 1 370 ? 135.878 151.900 109.915 1.00 52.19 ? 370 PHE A CB  1 
ATOM   2662 C  CG  . PHE A 1 370 ? 135.129 152.083 111.216 1.00 52.19 ? 370 PHE A CG  1 
ATOM   2663 C  CD1 . PHE A 1 370 ? 134.089 152.994 111.294 1.00 52.19 ? 370 PHE A CD1 1 
ATOM   2664 C  CD2 . PHE A 1 370 ? 135.524 151.439 112.377 1.00 52.19 ? 370 PHE A CD2 1 
ATOM   2665 C  CE1 . PHE A 1 370 ? 133.403 153.197 112.470 1.00 52.19 ? 370 PHE A CE1 1 
ATOM   2666 C  CE2 . PHE A 1 370 ? 134.845 151.646 113.569 1.00 52.19 ? 370 PHE A CE2 1 
ATOM   2667 C  CZ  . PHE A 1 370 ? 133.778 152.529 113.610 1.00 52.19 ? 370 PHE A CZ  1 
ATOM   2668 N  N   . PRO A 1 371 ? 136.177 148.657 108.293 1.00 49.44 ? 371 PRO A N   1 
ATOM   2669 C  CA  . PRO A 1 371 ? 136.758 147.333 108.534 1.00 49.44 ? 371 PRO A CA  1 
ATOM   2670 C  C   . PRO A 1 371 ? 138.265 147.417 108.721 1.00 49.44 ? 371 PRO A C   1 
ATOM   2671 O  O   . PRO A 1 371 ? 139.039 146.680 108.112 1.00 49.44 ? 371 PRO A O   1 
ATOM   2672 C  CB  . PRO A 1 371 ? 136.379 146.581 107.258 1.00 49.44 ? 371 PRO A CB  1 
ATOM   2673 C  CG  . PRO A 1 371 ? 136.442 147.616 106.226 1.00 49.44 ? 371 PRO A CG  1 
ATOM   2674 C  CD  . PRO A 1 371 ? 135.961 148.888 106.858 1.00 49.44 ? 371 PRO A CD  1 
ATOM   2675 N  N   . PHE A 1 372 ? 138.693 148.347 109.558 1.00 47.75 ? 372 PHE A N   1 
ATOM   2676 C  CA  . PHE A 1 372 ? 140.107 148.629 109.693 1.00 47.75 ? 372 PHE A CA  1 
ATOM   2677 C  C   . PHE A 1 372 ? 140.666 147.567 110.620 1.00 47.75 ? 372 PHE A C   1 
ATOM   2678 O  O   . PHE A 1 372 ? 140.175 147.402 111.733 1.00 47.75 ? 372 PHE A O   1 
ATOM   2679 C  CB  . PHE A 1 372 ? 140.335 150.038 110.245 1.00 47.75 ? 372 PHE A CB  1 
ATOM   2680 C  CG  . PHE A 1 372 ? 139.823 151.161 109.354 1.00 47.75 ? 372 PHE A CG  1 
ATOM   2681 C  CD1 . PHE A 1 372 ? 139.488 150.950 108.024 1.00 47.75 ? 372 PHE A CD1 1 
ATOM   2682 C  CD2 . PHE A 1 372 ? 139.696 152.438 109.855 1.00 47.75 ? 372 PHE A CD2 1 
ATOM   2683 C  CE1 . PHE A 1 372 ? 139.015 151.971 107.233 1.00 47.75 ? 372 PHE A CE1 1 
ATOM   2684 C  CE2 . PHE A 1 372 ? 139.235 153.464 109.058 1.00 47.75 ? 372 PHE A CE2 1 
ATOM   2685 C  CZ  . PHE A 1 372 ? 138.891 153.224 107.750 1.00 47.75 ? 372 PHE A CZ  1 
ATOM   2686 N  N   . PHE A 1 373 ? 141.649 146.811 110.152 1.00 45.37 ? 373 PHE A N   1 
ATOM   2687 C  CA  . PHE A 1 373 ? 142.126 145.680 110.938 1.00 45.37 ? 373 PHE A CA  1 
ATOM   2688 C  C   . PHE A 1 373 ? 143.167 146.084 111.968 1.00 45.37 ? 373 PHE A C   1 
ATOM   2689 O  O   . PHE A 1 373 ? 143.081 145.675 113.125 1.00 45.37 ? 373 PHE A O   1 
ATOM   2690 C  CB  . PHE A 1 373 ? 142.703 144.607 110.013 1.00 45.37 ? 373 PHE A CB  1 
ATOM   2691 C  CG  . PHE A 1 373 ? 143.136 143.362 110.719 1.00 45.37 ? 373 PHE A CG  1 
ATOM   2692 C  CD1 . PHE A 1 373 ? 142.218 142.432 111.145 1.00 45.37 ? 373 PHE A CD1 1 
ATOM   2693 C  CD2 . PHE A 1 373 ? 144.472 143.112 110.940 1.00 45.37 ? 373 PHE A CD2 1 
ATOM   2694 C  CE1 . PHE A 1 373 ? 142.633 141.280 111.789 1.00 45.37 ? 373 PHE A CE1 1 
ATOM   2695 C  CE2 . PHE A 1 373 ? 144.884 141.962 111.583 1.00 45.37 ? 373 PHE A CE2 1 
ATOM   2696 C  CZ  . PHE A 1 373 ? 143.965 141.049 112.007 1.00 45.37 ? 373 PHE A CZ  1 
ATOM   2697 N  N   . GLY A 1 374 ? 144.135 146.888 111.575 1.00 41.85 ? 374 GLY A N   1 
ATOM   2698 C  CA  . GLY A 1 374 ? 145.173 147.342 112.465 1.00 41.85 ? 374 GLY A CA  1 
ATOM   2699 C  C   . GLY A 1 374 ? 144.794 148.478 113.399 1.00 41.85 ? 374 GLY A C   1 
ATOM   2700 O  O   . GLY A 1 374 ? 144.897 148.338 114.620 1.00 41.85 ? 374 GLY A O   1 
ATOM   2701 N  N   . PRO A 1 375 ? 144.396 149.641 112.861 1.00 39.87 ? 375 PRO A N   1 
ATOM   2702 C  CA  . PRO A 1 375 ? 144.170 150.800 113.740 1.00 39.87 ? 375 PRO A CA  1 
ATOM   2703 C  C   . PRO A 1 375 ? 142.908 150.774 114.580 1.00 39.87 ? 375 PRO A C   1 
ATOM   2704 O  O   . PRO A 1 375 ? 142.717 151.705 115.368 1.00 39.87 ? 375 PRO A O   1 
ATOM   2705 C  CB  . PRO A 1 375 ? 144.130 151.974 112.763 1.00 39.87 ? 375 PRO A CB  1 
ATOM   2706 C  CG  . PRO A 1 375 ? 144.905 151.521 111.616 1.00 39.87 ? 375 PRO A CG  1 
ATOM   2707 C  CD  . PRO A 1 375 ? 144.589 150.084 111.469 1.00 39.87 ? 375 PRO A CD  1 
ATOM   2708 N  N   . ILE A 1 376 ? 142.035 149.775 114.460 1.00 40.00 ? 376 ILE A N   1 
ATOM   2709 C  CA  . ILE A 1 376 ? 140.901 149.737 115.372 1.00 40.00 ? 376 ILE A CA  1 
ATOM   2710 C  C   . ILE A 1 376 ? 141.326 149.164 116.718 1.00 40.00 ? 376 ILE A C   1 
ATOM   2711 O  O   . ILE A 1 376 ? 140.632 149.359 117.716 1.00 40.00 ? 376 ILE A O   1 
ATOM   2712 C  CB  . ILE A 1 376 ? 139.720 148.962 114.753 1.00 40.00 ? 376 ILE A CB  1 
ATOM   2713 C  CG1 . ILE A 1 376 ? 138.405 149.383 115.395 1.00 40.00 ? 376 ILE A CG1 1 
ATOM   2714 C  CG2 . ILE A 1 376 ? 139.857 147.486 114.969 1.00 40.00 ? 376 ILE A CG2 1 
ATOM   2715 C  CD1 . ILE A 1 376 ? 137.190 148.899 114.658 1.00 40.00 ? 376 ILE A CD1 1 
ATOM   2716 N  N   . ASN A 1 377 ? 142.470 148.479 116.784 1.00 39.67 ? 377 ASN A N   1 
ATOM   2717 C  CA  . ASN A 1 377 ? 142.933 147.955 118.063 1.00 39.67 ? 377 ASN A CA  1 
ATOM   2718 C  C   . ASN A 1 377 ? 143.506 149.055 118.937 1.00 39.67 ? 377 ASN A C   1 
ATOM   2719 O  O   . ASN A 1 377 ? 143.486 148.940 120.165 1.00 39.67 ? 377 ASN A O   1 
ATOM   2720 C  CB  . ASN A 1 377 ? 143.979 146.863 117.853 1.00 39.67 ? 377 ASN A CB  1 
ATOM   2721 C  CG  . ASN A 1 377 ? 143.379 145.565 117.399 1.00 39.67 ? 377 ASN A CG  1 
ATOM   2722 O  OD1 . ASN A 1 377 ? 142.346 145.149 117.887 1.00 39.67 ? 377 ASN A OD1 1 
ATOM   2723 N  ND2 . ASN A 1 377 ? 144.031 144.912 116.463 1.00 39.67 ? 377 ASN A ND2 1 
ATOM   2724 N  N   . SER A 1 378 ? 144.018 150.120 118.334 1.00 38.99 ? 378 SER A N   1 
ATOM   2725 C  CA  . SER A 1 378 ? 144.652 151.180 119.099 1.00 38.99 ? 378 SER A CA  1 
ATOM   2726 C  C   . SER A 1 378 ? 143.655 152.211 119.597 1.00 38.99 ? 378 SER A C   1 
ATOM   2727 O  O   . SER A 1 378 ? 143.903 152.847 120.622 1.00 38.99 ? 378 SER A O   1 
ATOM   2728 C  CB  . SER A 1 378 ? 145.724 151.869 118.257 1.00 38.99 ? 378 SER A CB  1 
ATOM   2729 O  OG  . SER A 1 378 ? 146.769 150.981 117.911 1.00 38.99 ? 378 SER A OG  1 
ATOM   2730 N  N   . ALA A 1 379 ? 142.536 152.400 118.897 1.00 38.12 ? 379 ALA A N   1 
ATOM   2731 C  CA  . ALA A 1 379 ? 141.521 153.324 119.383 1.00 38.12 ? 379 ALA A CA  1 
ATOM   2732 C  C   . ALA A 1 379 ? 140.662 152.695 120.466 1.00 38.12 ? 379 ALA A C   1 
ATOM   2733 O  O   . ALA A 1 379 ? 140.038 153.415 121.246 1.00 38.12 ? 379 ALA A O   1 
ATOM   2734 C  CB  . ALA A 1 379 ? 140.641 153.807 118.239 1.00 38.12 ? 379 ALA A CB  1 
ATOM   2735 N  N   . VAL A 1 380 ? 140.598 151.366 120.529 1.00 38.79 ? 380 VAL A N   1 
ATOM   2736 C  CA  . VAL A 1 380 ? 139.881 150.718 121.623 1.00 38.79 ? 380 VAL A CA  1 
ATOM   2737 C  C   . VAL A 1 380 ? 140.728 150.708 122.885 1.00 38.79 ? 380 VAL A C   1 
ATOM   2738 O  O   . VAL A 1 380 ? 140.263 151.098 123.957 1.00 38.79 ? 380 VAL A O   1 
ATOM   2739 C  CB  . VAL A 1 380 ? 139.449 149.303 121.214 1.00 38.79 ? 380 VAL A CB  1 
ATOM   2740 C  CG1 . VAL A 1 380 ? 138.880 148.556 122.391 1.00 38.79 ? 380 VAL A CG1 1 
ATOM   2741 C  CG2 . VAL A 1 380 ? 138.403 149.392 120.136 1.00 38.79 ? 380 VAL A CG2 1 
ATOM   2742 N  N   . GLY A 1 381 ? 141.996 150.319 122.775 1.00 36.26 ? 381 GLY A N   1 
ATOM   2743 C  CA  . GLY A 1 381 ? 142.882 150.292 123.926 1.00 36.26 ? 381 GLY A CA  1 
ATOM   2744 C  C   . GLY A 1 381 ? 143.341 151.649 124.412 1.00 36.26 ? 381 GLY A C   1 
ATOM   2745 O  O   . GLY A 1 381 ? 144.113 151.719 125.372 1.00 36.26 ? 381 GLY A O   1 
ATOM   2746 N  N   . ALA A 1 382 ? 142.927 152.718 123.761 1.00 37.63 ? 382 ALA A N   1 
ATOM   2747 C  CA  . ALA A 1 382 ? 143.204 154.052 124.251 1.00 37.63 ? 382 ALA A CA  1 
ATOM   2748 C  C   . ALA A 1 382 ? 142.084 154.591 125.112 1.00 37.63 ? 382 ALA A C   1 
ATOM   2749 O  O   . ALA A 1 382 ? 142.340 155.259 126.113 1.00 37.63 ? 382 ALA A O   1 
ATOM   2750 C  CB  . ALA A 1 382 ? 143.425 155.002 123.079 1.00 37.63 ? 382 ALA A CB  1 
ATOM   2751 N  N   . LEU A 1 383 ? 140.848 154.294 124.747 1.00 38.42 ? 383 LEU A N   1 
ATOM   2752 C  CA  . LEU A 1 383 ? 139.697 154.915 125.371 1.00 38.42 ? 383 LEU A CA  1 
ATOM   2753 C  C   . LEU A 1 383 ? 139.003 154.003 126.368 1.00 38.42 ? 383 LEU A C   1 
ATOM   2754 O  O   . LEU A 1 383 ? 138.331 154.501 127.274 1.00 38.42 ? 383 LEU A O   1 
ATOM   2755 C  CB  . LEU A 1 383 ? 138.710 155.335 124.288 1.00 38.42 ? 383 LEU A CB  1 
ATOM   2756 C  CG  . LEU A 1 383 ? 139.342 156.245 123.238 1.00 38.42 ? 383 LEU A CG  1 
ATOM   2757 C  CD1 . LEU A 1 383 ? 138.379 156.474 122.094 1.00 38.42 ? 383 LEU A CD1 1 
ATOM   2758 C  CD2 . LEU A 1 383 ? 139.765 157.552 123.844 1.00 38.42 ? 383 LEU A CD2 1 
ATOM   2759 N  N   . LEU A 1 384 ? 139.149 152.689 126.229 1.00 41.50 ? 384 LEU A N   1 
ATOM   2760 C  CA  . LEU A 1 384 ? 138.415 151.763 127.074 1.00 41.50 ? 384 LEU A CA  1 
ATOM   2761 C  C   . LEU A 1 384 ? 139.312 150.857 127.899 1.00 41.50 ? 384 LEU A C   1 
ATOM   2762 O  O   . LEU A 1 384 ? 139.101 150.719 129.103 1.00 41.50 ? 384 LEU A O   1 
ATOM   2763 C  CB  . LEU A 1 384 ? 137.486 150.910 126.224 1.00 41.50 ? 384 LEU A CB  1 
ATOM   2764 C  CG  . LEU A 1 384 ? 136.397 151.712 125.522 1.00 41.50 ? 384 LEU A CG  1 
ATOM   2765 C  CD1 . LEU A 1 384 ? 135.623 150.833 124.565 1.00 41.50 ? 384 LEU A CD1 1 
ATOM   2766 C  CD2 . LEU A 1 384 ? 135.471 152.337 126.545 1.00 41.50 ? 384 LEU A CD2 1 
ATOM   2767 N  N   . VAL A 1 385 ? 140.306 150.228 127.272 1.00 39.84 ? 385 VAL A N   1 
ATOM   2768 C  CA  . VAL A 1 385 ? 141.074 149.186 127.940 1.00 39.84 ? 385 VAL A CA  1 
ATOM   2769 C  C   . VAL A 1 385 ? 142.038 149.781 128.955 1.00 39.84 ? 385 VAL A C   1 
ATOM   2770 O  O   . VAL A 1 385 ? 142.471 149.094 129.884 1.00 39.84 ? 385 VAL A O   1 
ATOM   2771 C  CB  . VAL A 1 385 ? 141.793 148.336 126.881 1.00 39.84 ? 385 VAL A CB  1 
ATOM   2772 C  CG1 . VAL A 1 385 ? 142.432 147.102 127.465 1.00 39.84 ? 385 VAL A CG1 1 
ATOM   2773 C  CG2 . VAL A 1 385 ? 140.821 147.920 125.846 1.00 39.84 ? 385 VAL A CG2 1 
ATOM   2774 N  N   . SER A 1 386 ? 142.364 151.065 128.838 1.00 40.82 ? 386 SER A N   1 
ATOM   2775 C  CA  . SER A 1 386 ? 143.231 151.671 129.839 1.00 40.82 ? 386 SER A CA  1 
ATOM   2776 C  C   . SER A 1 386 ? 142.503 151.849 131.163 1.00 40.82 ? 386 SER A C   1 
ATOM   2777 O  O   . SER A 1 386 ? 143.115 151.753 132.227 1.00 40.82 ? 386 SER A O   1 
ATOM   2778 C  CB  . SER A 1 386 ? 143.784 152.995 129.332 1.00 40.82 ? 386 SER A CB  1 
ATOM   2779 O  OG  . SER A 1 386 ? 142.768 153.953 129.174 1.00 40.82 ? 386 SER A OG  1 
ATOM   2780 N  N   . PHE A 1 387 ? 141.189 152.060 131.125 1.00 43.11 ? 387 PHE A N   1 
ATOM   2781 C  CA  . PHE A 1 387 ? 140.400 152.206 132.344 1.00 43.11 ? 387 PHE A CA  1 
ATOM   2782 C  C   . PHE A 1 387 ? 139.859 150.889 132.877 1.00 43.11 ? 387 PHE A C   1 
ATOM   2783 O  O   . PHE A 1 387 ? 139.737 150.727 134.092 1.00 43.11 ? 387 PHE A O   1 
ATOM   2784 C  CB  . PHE A 1 387 ? 139.214 153.137 132.103 1.00 43.11 ? 387 PHE A CB  1 
ATOM   2785 C  CG  . PHE A 1 387 ? 139.588 154.566 131.912 1.00 43.11 ? 387 PHE A CG  1 
ATOM   2786 C  CD1 . PHE A 1 387 ? 139.793 155.390 132.996 1.00 43.11 ? 387 PHE A CD1 1 
ATOM   2787 C  CD2 . PHE A 1 387 ? 139.720 155.091 130.645 1.00 43.11 ? 387 PHE A CD2 1 
ATOM   2788 C  CE1 . PHE A 1 387 ? 140.132 156.716 132.815 1.00 43.11 ? 387 PHE A CE1 1 
ATOM   2789 C  CE2 . PHE A 1 387 ? 140.062 156.407 130.459 1.00 43.11 ? 387 PHE A CE2 1 
ATOM   2790 C  CZ  . PHE A 1 387 ? 140.269 157.221 131.545 1.00 43.11 ? 387 PHE A CZ  1 
ATOM   2791 N  N   . THR A 1 388 ? 139.515 149.960 131.990 1.00 41.87 ? 388 THR A N   1 
ATOM   2792 C  CA  . THR A 1 388 ? 138.875 148.709 132.378 1.00 41.87 ? 388 THR A CA  1 
ATOM   2793 C  C   . THR A 1 388 ? 139.833 147.815 133.154 1.00 41.87 ? 388 THR A C   1 
ATOM   2794 O  O   . THR A 1 388 ? 139.424 147.126 134.094 1.00 41.87 ? 388 THR A O   1 
ATOM   2795 C  CB  . THR A 1 388 ? 138.351 148.011 131.118 1.00 41.87 ? 388 THR A CB  1 
ATOM   2796 O  OG1 . THR A 1 388 ? 137.392 148.856 130.478 1.00 41.87 ? 388 THR A OG1 1 
ATOM   2797 C  CG2 . THR A 1 388 ? 137.675 146.701 131.426 1.00 41.87 ? 388 THR A CG2 1 
ATOM   2798 N  N   . VAL A 1 389 ? 141.115 147.864 132.822 1.00 43.74 ? 389 VAL A N   1 
ATOM   2799 C  CA  . VAL A 1 389 ? 142.108 146.936 133.340 1.00 43.74 ? 389 VAL A CA  1 
ATOM   2800 C  C   . VAL A 1 389 ? 143.077 147.625 134.298 1.00 43.74 ? 389 VAL A C   1 
ATOM   2801 O  O   . VAL A 1 389 ? 143.408 147.087 135.354 1.00 43.74 ? 389 VAL A O   1 
ATOM   2802 C  CB  . VAL A 1 389 ? 142.864 146.254 132.181 1.00 43.74 ? 389 VAL A CB  1 
ATOM   2803 C  CG1 . VAL A 1 389 ? 143.926 145.348 132.706 1.00 43.74 ? 389 VAL A CG1 1 
ATOM   2804 C  CG2 . VAL A 1 389 ? 141.900 145.479 131.326 1.00 43.74 ? 389 VAL A CG2 1 
ATOM   2805 N  N   . TYR A 1 390 ? 143.506 148.839 133.967 1.00 43.96 ? 390 TYR A N   1 
ATOM   2806 C  CA  . TYR A 1 390 ? 144.664 149.437 134.617 1.00 43.96 ? 390 TYR A CA  1 
ATOM   2807 C  C   . TYR A 1 390 ? 144.337 150.574 135.573 1.00 43.96 ? 390 TYR A C   1 
ATOM   2808 O  O   . TYR A 1 390 ? 145.178 150.905 136.408 1.00 43.96 ? 390 TYR A O   1 
ATOM   2809 C  CB  . TYR A 1 390 ? 145.640 149.961 133.562 1.00 43.96 ? 390 TYR A CB  1 
ATOM   2810 C  CG  . TYR A 1 390 ? 146.304 148.904 132.706 1.00 43.96 ? 390 TYR A CG  1 
ATOM   2811 C  CD1 . TYR A 1 390 ? 147.521 148.357 133.061 1.00 43.96 ? 390 TYR A CD1 1 
ATOM   2812 C  CD2 . TYR A 1 390 ? 145.699 148.449 131.546 1.00 43.96 ? 390 TYR A CD2 1 
ATOM   2813 C  CE1 . TYR A 1 390 ? 148.123 147.401 132.272 1.00 43.96 ? 390 TYR A CE1 1 
ATOM   2814 C  CE2 . TYR A 1 390 ? 146.288 147.489 130.767 1.00 43.96 ? 390 TYR A CE2 1 
ATOM   2815 C  CZ  . TYR A 1 390 ? 147.497 146.975 131.134 1.00 43.96 ? 390 TYR A CZ  1 
ATOM   2816 O  OH  . TYR A 1 390 ? 148.093 146.021 130.360 1.00 43.96 ? 390 TYR A OH  1 
ATOM   2817 N  N   . ILE A 1 391 ? 143.165 151.198 135.490 1.00 43.98 ? 391 ILE A N   1 
ATOM   2818 C  CA  . ILE A 1 391 ? 142.889 152.336 136.363 1.00 43.98 ? 391 ILE A CA  1 
ATOM   2819 C  C   . ILE A 1 391 ? 141.951 151.947 137.494 1.00 43.98 ? 391 ILE A C   1 
ATOM   2820 O  O   . ILE A 1 391 ? 142.243 152.202 138.666 1.00 43.98 ? 391 ILE A O   1 
ATOM   2821 C  CB  . ILE A 1 391 ? 142.304 153.525 135.583 1.00 43.98 ? 391 ILE A CB  1 
ATOM   2822 C  CG1 . ILE A 1 391 ? 143.285 154.001 134.533 1.00 43.98 ? 391 ILE A CG1 1 
ATOM   2823 C  CG2 . ILE A 1 391 ? 141.993 154.666 136.510 1.00 43.98 ? 391 ILE A CG2 1 
ATOM   2824 C  CD1 . ILE A 1 391 ? 144.592 154.370 135.105 1.00 43.98 ? 391 ILE A CD1 1 
ATOM   2825 N  N   . ILE A 1 392 ? 140.813 151.356 137.156 1.00 44.47 ? 392 ILE A N   1 
ATOM   2826 C  CA  . ILE A 1 392 ? 139.799 151.023 138.152 1.00 44.47 ? 392 ILE A CA  1 
ATOM   2827 C  C   . ILE A 1 392 ? 140.272 149.896 139.077 1.00 44.47 ? 392 ILE A C   1 
ATOM   2828 O  O   . ILE A 1 392 ? 140.070 150.026 140.292 1.00 44.47 ? 392 ILE A O   1 
ATOM   2829 C  CB  . ILE A 1 392 ? 138.444 150.730 137.482 1.00 44.47 ? 392 ILE A CB  1 
ATOM   2830 C  CG1 . ILE A 1 392 ? 137.987 151.939 136.685 1.00 44.47 ? 392 ILE A CG1 1 
ATOM   2831 C  CG2 . ILE A 1 392 ? 137.385 150.460 138.506 1.00 44.47 ? 392 ILE A CG2 1 
ATOM   2832 C  CD1 . ILE A 1 392 ? 136.780 151.671 135.850 1.00 44.47 ? 392 ILE A CD1 1 
ATOM   2833 N  N   . PRO A 1 393 ? 140.941 148.819 138.634 1.00 44.31 ? 393 PRO A N   1 
ATOM   2834 C  CA  . PRO A 1 393 ? 141.546 147.915 139.624 1.00 44.31 ? 393 PRO A CA  1 
ATOM   2835 C  C   . PRO A 1 393 ? 142.727 148.482 140.399 1.00 44.31 ? 393 PRO A C   1 
ATOM   2836 O  O   . PRO A 1 393 ? 143.238 147.790 141.278 1.00 44.31 ? 393 PRO A O   1 
ATOM   2837 C  CB  . PRO A 1 393 ? 141.969 146.715 138.779 1.00 44.31 ? 393 PRO A CB  1 
ATOM   2838 C  CG  . PRO A 1 393 ? 141.051 146.711 137.681 1.00 44.31 ? 393 PRO A CG  1 
ATOM   2839 C  CD  . PRO A 1 393 ? 140.874 148.129 137.332 1.00 44.31 ? 393 PRO A CD  1 
ATOM   2840 N  N   . SER A 1 394 ? 143.193 149.694 140.122 1.00 45.14 ? 394 SER A N   1 
ATOM   2841 C  CA  . SER A 1 394 ? 144.162 150.327 141.006 1.00 45.14 ? 394 SER A CA  1 
ATOM   2842 C  C   . SER A 1 394 ? 143.569 151.490 141.780 1.00 45.14 ? 394 SER A C   1 
ATOM   2843 O  O   . SER A 1 394 ? 144.200 151.976 142.721 1.00 45.14 ? 394 SER A O   1 
ATOM   2844 C  CB  . SER A 1 394 ? 145.387 150.806 140.229 1.00 45.14 ? 394 SER A CB  1 
ATOM   2845 O  OG  . SER A 1 394 ? 146.146 149.715 139.744 1.00 45.14 ? 394 SER A OG  1 
ATOM   2846 N  N   . LEU A 1 395 ? 142.382 151.962 141.400 1.00 45.30 ? 395 LEU A N   1 
ATOM   2847 C  CA  . LEU A 1 395 ? 141.679 152.926 142.235 1.00 45.30 ? 395 LEU A CA  1 
ATOM   2848 C  C   . LEU A 1 395 ? 140.790 152.248 143.259 1.00 45.30 ? 395 LEU A C   1 
ATOM   2849 O  O   . LEU A 1 395 ? 140.518 152.830 144.312 1.00 45.30 ? 395 LEU A O   1 
ATOM   2850 C  CB  . LEU A 1 395 ? 140.843 153.882 141.393 1.00 45.30 ? 395 LEU A CB  1 
ATOM   2851 C  CG  . LEU A 1 395 ? 141.619 154.990 140.710 1.00 45.30 ? 395 LEU A CG  1 
ATOM   2852 C  CD1 . LEU A 1 395 ? 140.687 155.743 139.823 1.00 45.30 ? 395 LEU A CD1 1 
ATOM   2853 C  CD2 . LEU A 1 395 ? 142.158 155.901 141.767 1.00 45.30 ? 395 LEU A CD2 1 
ATOM   2854 N  N   . ALA A 1 396 ? 140.337 151.027 142.986 1.00 48.72 ? 396 ALA A N   1 
ATOM   2855 C  CA  . ALA A 1 396 ? 139.518 150.328 143.963 1.00 48.72 ? 396 ALA A CA  1 
ATOM   2856 C  C   . ALA A 1 396 ? 140.337 149.807 145.133 1.00 48.72 ? 396 ALA A C   1 
ATOM   2857 O  O   . ALA A 1 396 ? 139.775 149.550 146.197 1.00 48.72 ? 396 ALA A O   1 
ATOM   2858 C  CB  . ALA A 1 396 ? 138.765 149.185 143.293 1.00 48.72 ? 396 ALA A CB  1 
ATOM   2859 N  N   . HIS A 1 397 ? 141.642 149.664 144.973 1.00 49.92 ? 397 HIS A N   1 
ATOM   2860 C  CA  . HIS A 1 397 ? 142.493 149.234 146.064 1.00 49.92 ? 397 HIS A CA  1 
ATOM   2861 C  C   . HIS A 1 397 ? 143.063 150.399 146.855 1.00 49.92 ? 397 HIS A C   1 
ATOM   2862 O  O   . HIS A 1 397 ? 143.534 150.194 147.975 1.00 49.92 ? 397 HIS A O   1 
ATOM   2863 C  CB  . HIS A 1 397 ? 143.624 148.370 145.517 1.00 49.92 ? 397 HIS A CB  1 
ATOM   2864 C  CG  . HIS A 1 397 ? 144.395 147.646 146.568 1.00 49.92 ? 397 HIS A CG  1 
ATOM   2865 N  ND1 . HIS A 1 397 ? 145.446 148.223 147.243 1.00 49.92 ? 397 HIS A ND1 1 
ATOM   2866 C  CD2 . HIS A 1 397 ? 144.260 146.400 147.075 1.00 49.92 ? 397 HIS A CD2 1 
ATOM   2867 C  CE1 . HIS A 1 397 ? 145.935 147.358 148.111 1.00 49.92 ? 397 HIS A CE1 1 
ATOM   2868 N  NE2 . HIS A 1 397 ? 145.234 146.243 148.028 1.00 49.92 ? 397 HIS A NE2 1 
ATOM   2869 N  N   . MET A 1 398 ? 143.045 151.613 146.309 1.00 52.70 ? 398 MET A N   1 
ATOM   2870 C  CA  . MET A 1 398 ? 143.439 152.775 147.099 1.00 52.70 ? 398 MET A CA  1 
ATOM   2871 C  C   . MET A 1 398 ? 142.326 153.198 148.040 1.00 52.70 ? 398 MET A C   1 
ATOM   2872 O  O   . MET A 1 398 ? 142.558 153.440 149.226 1.00 52.70 ? 398 MET A O   1 
ATOM   2873 C  CB  . MET A 1 398 ? 143.789 153.957 146.207 1.00 52.70 ? 398 MET A CB  1 
ATOM   2874 C  CG  . MET A 1 398 ? 145.050 153.886 145.419 1.00 52.70 ? 398 MET A CG  1 
ATOM   2875 S  SD  . MET A 1 398 ? 145.135 155.512 144.676 1.00 52.70 ? 398 MET A SD  1 
ATOM   2876 C  CE  . MET A 1 398 ? 146.582 155.336 143.693 1.00 52.70 ? 398 MET A CE  1 
ATOM   2877 N  N   . LEU A 1 399 ? 141.117 153.331 147.511 1.00 53.83 ? 399 LEU A N   1 
ATOM   2878 C  CA  . LEU A 1 399 ? 140.005 153.880 148.264 1.00 53.83 ? 399 LEU A CA  1 
ATOM   2879 C  C   . LEU A 1 399 ? 139.479 152.943 149.337 1.00 53.83 ? 399 LEU A C   1 
ATOM   2880 O  O   . LEU A 1 399 ? 138.908 153.420 150.318 1.00 53.83 ? 399 LEU A O   1 
ATOM   2881 C  CB  . LEU A 1 399 ? 138.869 154.219 147.313 1.00 53.83 ? 399 LEU A CB  1 
ATOM   2882 C  CG  . LEU A 1 399 ? 139.207 155.241 146.243 1.00 53.83 ? 399 LEU A CG  1 
ATOM   2883 C  CD1 . LEU A 1 399 ? 138.031 155.364 145.326 1.00 53.83 ? 399 LEU A CD1 1 
ATOM   2884 C  CD2 . LEU A 1 399 ? 139.542 156.573 146.860 1.00 53.83 ? 399 LEU A CD2 1 
ATOM   2885 N  N   . THR A 1 400 ? 139.621 151.633 149.162 1.00 54.65 ? 400 THR A N   1 
ATOM   2886 C  CA  . THR A 1 400 ? 139.128 150.702 150.167 1.00 54.65 ? 400 THR A CA  1 
ATOM   2887 C  C   . THR A 1 400 ? 139.996 150.749 151.410 1.00 54.65 ? 400 THR A C   1 
ATOM   2888 O  O   . THR A 1 400 ? 139.493 150.830 152.533 1.00 54.65 ? 400 THR A O   1 
ATOM   2889 C  CB  . THR A 1 400 ? 139.090 149.294 149.594 1.00 54.65 ? 400 THR A CB  1 
ATOM   2890 O  OG1 . THR A 1 400 ? 138.227 149.278 148.458 1.00 54.65 ? 400 THR A OG1 1 
ATOM   2891 C  CG2 . THR A 1 400 ? 138.570 148.322 150.610 1.00 54.65 ? 400 THR A CG2 1 
ATOM   2892 N  N   . TYR A 1 401 ? 141.305 150.721 151.224 1.00 57.96 ? 401 TYR A N   1 
ATOM   2893 C  CA  . TYR A 1 401 ? 142.247 150.742 152.333 1.00 57.96 ? 401 TYR A CA  1 
ATOM   2894 C  C   . TYR A 1 401 ? 142.711 152.160 152.650 1.00 57.96 ? 401 TYR A C   1 
ATOM   2895 O  O   . TYR A 1 401 ? 143.895 152.402 152.860 1.00 57.96 ? 401 TYR A O   1 
ATOM   2896 C  CB  . TYR A 1 401 ? 143.421 149.843 151.980 1.00 57.96 ? 401 TYR A CB  1 
ATOM   2897 C  CG  . TYR A 1 401 ? 143.057 148.384 151.897 1.00 57.96 ? 401 TYR A CG  1 
ATOM   2898 C  CD1 . TYR A 1 401 ? 143.098 147.580 153.018 1.00 57.96 ? 401 TYR A CD1 1 
ATOM   2899 C  CD2 . TYR A 1 401 ? 142.640 147.818 150.703 1.00 57.96 ? 401 TYR A CD2 1 
ATOM   2900 C  CE1 . TYR A 1 401 ? 142.765 146.254 152.950 1.00 57.96 ? 401 TYR A CE1 1 
ATOM   2901 C  CE2 . TYR A 1 401 ? 142.293 146.488 150.630 1.00 57.96 ? 401 TYR A CE2 1 
ATOM   2902 C  CZ  . TYR A 1 401 ? 142.361 145.716 151.757 1.00 57.96 ? 401 TYR A CZ  1 
ATOM   2903 O  OH  . TYR A 1 401 ? 142.021 144.391 151.696 1.00 57.96 ? 401 TYR A OH  1 
ATOM   2904 N  N   . ARG A 1 402 ? 141.783 153.112 152.734 1.00 61.41 ? 402 ARG A N   1 
ATOM   2905 C  CA  . ARG A 1 402 ? 142.169 154.514 152.821 1.00 61.41 ? 402 ARG A CA  1 
ATOM   2906 C  C   . ARG A 1 402 ? 142.160 155.042 154.240 1.00 61.41 ? 402 ARG A C   1 
ATOM   2907 O  O   . ARG A 1 402 ? 142.427 156.229 154.444 1.00 61.41 ? 402 ARG A O   1 
ATOM   2908 C  CB  . ARG A 1 402 ? 141.268 155.397 151.948 1.00 61.41 ? 402 ARG A CB  1 
ATOM   2909 C  CG  . ARG A 1 402 ? 139.858 155.664 152.468 1.00 61.41 ? 402 ARG A CG  1 
ATOM   2910 C  CD  . ARG A 1 402 ? 139.110 156.546 151.464 1.00 61.41 ? 402 ARG A CD  1 
ATOM   2911 N  NE  . ARG A 1 402 ? 137.786 156.986 151.900 1.00 61.41 ? 402 ARG A NE  1 
ATOM   2912 C  CZ  . ARG A 1 402 ? 136.649 156.357 151.623 1.00 61.41 ? 402 ARG A CZ  1 
ATOM   2913 N  NH1 . ARG A 1 402 ? 136.657 155.254 150.897 1.00 61.41 ? 402 ARG A NH1 1 
ATOM   2914 N  NH2 . ARG A 1 402 ? 135.499 156.844 152.061 1.00 61.41 ? 402 ARG A NH2 1 
ATOM   2915 N  N   . SER A 1 403 ? 141.875 154.203 155.221 1.00 67.41 ? 403 SER A N   1 
ATOM   2916 C  CA  . SER A 1 403 ? 141.925 154.610 156.614 1.00 67.41 ? 403 SER A CA  1 
ATOM   2917 C  C   . SER A 1 403 ? 142.869 153.679 157.364 1.00 67.41 ? 403 SER A C   1 
ATOM   2918 O  O   . SER A 1 403 ? 143.520 152.818 156.773 1.00 67.41 ? 403 SER A O   1 
ATOM   2919 C  CB  . SER A 1 403 ? 140.528 154.611 157.234 1.00 67.41 ? 403 SER A CB  1 
ATOM   2920 O  OG  . SER A 1 403 ? 140.577 155.041 158.579 1.00 67.41 ? 403 SER A OG  1 
ATOM   2921 N  N   . ALA A 1 404 ? 142.948 153.863 158.679 1.00 69.65 ? 404 ALA A N   1 
ATOM   2922 C  CA  . ALA A 1 404 ? 143.804 153.029 159.509 1.00 69.65 ? 404 ALA A CA  1 
ATOM   2923 C  C   . ALA A 1 404 ? 143.087 151.816 160.071 1.00 69.65 ? 404 ALA A C   1 
ATOM   2924 O  O   . ALA A 1 404 ? 143.750 150.867 160.499 1.00 69.65 ? 404 ALA A O   1 
ATOM   2925 C  CB  . ALA A 1 404 ? 144.379 153.846 160.667 1.00 69.65 ? 404 ALA A CB  1 
ATOM   2926 N  N   . SER A 1 405 ? 141.758 151.829 160.083 1.00 71.16 ? 405 SER A N   1 
ATOM   2927 C  CA  . SER A 1 405 ? 141.005 150.697 160.599 1.00 71.16 ? 405 SER A CA  1 
ATOM   2928 C  C   . SER A 1 405 ? 140.646 149.702 159.504 1.00 71.16 ? 405 SER A C   1 
ATOM   2929 O  O   . SER A 1 405 ? 140.245 148.573 159.807 1.00 71.16 ? 405 SER A O   1 
ATOM   2930 C  CB  . SER A 1 405 ? 139.745 151.194 161.305 1.00 71.16 ? 405 SER A CB  1 
ATOM   2931 O  OG  . SER A 1 405 ? 138.898 151.874 160.400 1.00 71.16 ? 405 SER A OG  1 
ATOM   2932 N  N   . ALA A 1 406 ? 140.767 150.096 158.237 1.00 68.41 ? 406 ALA A N   1 
ATOM   2933 C  CA  . ALA A 1 406 ? 140.521 149.152 157.157 1.00 68.41 ? 406 ALA A CA  1 
ATOM   2934 C  C   . ALA A 1 406 ? 141.754 148.293 156.925 1.00 68.41 ? 406 ALA A C   1 
ATOM   2935 O  O   . ALA A 1 406 ? 141.635 147.137 156.509 1.00 68.41 ? 406 ALA A O   1 
ATOM   2936 C  CB  . ALA A 1 406 ? 140.011 149.889 155.924 1.00 68.41 ? 406 ALA A CB  1 
ATOM   2937 N  N   . ARG A 1 407 ? 142.938 148.841 157.173 1.00 69.97 ? 407 ARG A N   1 
ATOM   2938 C  CA  . ARG A 1 407 ? 144.184 148.092 157.099 1.00 69.97 ? 407 ARG A CA  1 
ATOM   2939 C  C   . ARG A 1 407 ? 144.504 147.228 158.302 1.00 69.97 ? 407 ARG A C   1 
ATOM   2940 O  O   . ARG A 1 407 ? 145.228 146.238 158.160 1.00 69.97 ? 407 ARG A O   1 
ATOM   2941 C  CB  . ARG A 1 407 ? 145.326 149.076 156.863 1.00 69.97 ? 407 ARG A CB  1 
ATOM   2942 C  CG  . ARG A 1 407 ? 145.287 149.726 155.508 1.00 69.97 ? 407 ARG A CG  1 
ATOM   2943 C  CD  . ARG A 1 407 ? 146.293 150.835 155.392 1.00 69.97 ? 407 ARG A CD  1 
ATOM   2944 N  NE  . ARG A 1 407 ? 145.879 151.975 156.193 1.00 69.97 ? 407 ARG A NE  1 
ATOM   2945 C  CZ  . ARG A 1 407 ? 146.609 153.065 156.371 1.00 69.97 ? 407 ARG A CZ  1 
ATOM   2946 N  NH1 . ARG A 1 407 ? 147.799 153.162 155.802 1.00 69.97 ? 407 ARG A NH1 1 
ATOM   2947 N  NH2 . ARG A 1 407 ? 146.149 154.057 157.120 1.00 69.97 ? 407 ARG A NH2 1 
ATOM   2948 N  N   . GLN A 1 408 ? 143.983 147.593 159.472 1.00 75.43 ? 408 GLN A N   1 
ATOM   2949 C  CA  . GLN A 1 408 ? 144.206 146.831 160.694 1.00 75.43 ? 408 GLN A CA  1 
ATOM   2950 C  C   . GLN A 1 408 ? 143.581 145.445 160.597 1.00 75.43 ? 408 GLN A C   1 
ATOM   2951 O  O   . GLN A 1 408 ? 144.100 144.476 161.161 1.00 75.43 ? 408 GLN A O   1 
ATOM   2952 C  CB  . GLN A 1 408 ? 143.633 147.616 161.874 1.00 75.43 ? 408 GLN A CB  1 
ATOM   2953 C  CG  . GLN A 1 408 ? 143.844 147.009 163.237 1.00 75.43 ? 408 GLN A CG  1 
ATOM   2954 C  CD  . GLN A 1 408 ? 145.295 146.991 163.644 1.00 75.43 ? 408 GLN A CD  1 
ATOM   2955 O  OE1 . GLN A 1 408 ? 146.035 147.938 163.385 1.00 75.43 ? 408 GLN A OE1 1 
ATOM   2956 N  NE2 . GLN A 1 408 ? 145.711 145.915 164.300 1.00 75.43 ? 408 GLN A NE2 1 
ATOM   2957 N  N   . ASN A 1 409 ? 142.509 145.329 159.854 1.00 75.43 ? 409 ASN A N   1 
ATOM   2958 C  CA  . ASN A 1 409 ? 141.870 144.066 159.753 1.00 75.43 ? 409 ASN A CA  1 
ATOM   2959 C  C   . ASN A 1 409 ? 141.823 143.584 158.323 1.00 75.43 ? 409 ASN A C   1 
ATOM   2960 O  O   . ASN A 1 409 ? 140.824 143.013 157.891 1.00 75.43 ? 409 ASN A O   1 
ATOM   2961 C  CB  . ASN A 1 409 ? 140.499 144.142 160.372 1.00 75.43 ? 409 ASN A CB  1 
ATOM   2962 C  CG  . ASN A 1 409 ? 140.533 144.258 161.867 1.00 75.43 ? 409 ASN A CG  1 
ATOM   2963 O  OD1 . ASN A 1 409 ? 141.502 143.878 162.502 1.00 75.43 ? 409 ASN A OD1 1 
ATOM   2964 N  ND2 . ASN A 1 409 ? 139.460 144.763 162.440 1.00 75.43 ? 409 ASN A ND2 1 
ATOM   2965 N  N   . ALA A 1 410 ? 142.899 143.790 157.578 1.00 75.99 ? 410 ALA A N   1 
ATOM   2966 C  CA  . ALA A 1 410 ? 142.969 143.301 156.207 1.00 75.99 ? 410 ALA A CA  1 
ATOM   2967 C  C   . ALA A 1 410 ? 143.113 141.843 156.027 1.00 75.99 ? 410 ALA A C   1 
ATOM   2968 O  O   . ALA A 1 410 ? 144.028 141.255 156.573 1.00 75.99 ? 410 ALA A O   1 
ATOM   2969 C  CB  . ALA A 1 410 ? 144.146 143.916 155.564 1.00 75.99 ? 410 ALA A CB  1 
ATOM   2970 N  N   . ALA A 1 411 ? 142.279 141.253 155.196 1.00 76.53 ? 411 ALA A N   1 
ATOM   2971 C  CA  . ALA A 1 411 ? 142.297 139.831 155.022 1.00 76.53 ? 411 ALA A CA  1 
ATOM   2972 C  C   . ALA A 1 411 ? 143.614 139.265 154.520 1.00 76.53 ? 411 ALA A C   1 
ATOM   2973 O  O   . ALA A 1 411 ? 144.125 138.328 155.105 1.00 76.53 ? 411 ALA A O   1 
ATOM   2974 C  CB  . ALA A 1 411 ? 141.178 139.444 154.140 1.00 76.53 ? 411 ALA A CB  1 
ATOM   2975 N  N   . GLU A 1 412 ? 144.194 139.803 153.454 1.00 78.67 ? 412 GLU A N   1 
ATOM   2976 C  CA  . GLU A 1 412 ? 145.513 139.347 152.988 1.00 78.67 ? 412 GLU A CA  1 
ATOM   2977 C  C   . GLU A 1 412 ? 146.623 140.375 153.111 1.00 78.67 ? 412 GLU A C   1 
ATOM   2978 O  O   . GLU A 1 412 ? 146.720 141.235 152.251 1.00 78.67 ? 412 GLU A O   1 
ATOM   2979 C  CB  . GLU A 1 412 ? 145.435 138.946 151.552 1.00 78.67 ? 412 GLU A CB  1 
ATOM   2980 C  CG  . GLU A 1 412 ? 144.551 137.745 151.291 1.00 78.67 ? 412 GLU A CG  1 
ATOM   2981 C  CD  . GLU A 1 412 ? 144.993 136.521 152.064 1.00 78.67 ? 412 GLU A CD  1 
ATOM   2982 O  OE1 . GLU A 1 412 ? 146.212 136.289 152.167 1.00 78.67 ? 412 GLU A OE1 1 
ATOM   2983 O  OE2 . GLU A 1 412 ? 144.119 135.790 152.574 1.00 78.67 ? 412 GLU A OE2 1 
ATOM   2984 N  N   . LYS A 1 413 ? 147.473 140.287 154.146 1.00 83.09 ? 413 LYS A N   1 
ATOM   2985 C  CA  . LYS A 1 413 ? 148.559 141.254 154.413 1.00 83.09 ? 413 LYS A CA  1 
ATOM   2986 C  C   . LYS A 1 413 ? 149.534 141.553 153.258 1.00 83.09 ? 413 LYS A C   1 
ATOM   2987 O  O   . LYS A 1 413 ? 149.769 140.689 152.422 1.00 83.09 ? 413 LYS A O   1 
ATOM   2988 C  CB  . LYS A 1 413 ? 149.333 140.780 155.637 1.00 83.09 ? 413 LYS A CB  1 
ATOM   2989 C  CG  . LYS A 1 413 ? 150.002 139.437 155.502 1.00 83.09 ? 413 LYS A CG  1 
ATOM   2990 C  CD  . LYS A 1 413 ? 151.233 139.381 156.386 1.00 83.09 ? 413 LYS A CD  1 
ATOM   2991 C  CE  . LYS A 1 413 ? 152.396 140.138 155.768 1.00 83.09 ? 413 LYS A CE  1 
ATOM   2992 N  NZ  . LYS A 1 413 ? 153.729 139.631 156.199 1.00 83.09 ? 413 LYS A NZ  1 
ATOM   2993 N  N   . PRO A 1 414 ? 150.172 142.781 153.202 1.00 82.03 ? 414 PRO A N   1 
ATOM   2994 C  CA  . PRO A 1 414 ? 151.097 142.976 152.057 1.00 82.03 ? 414 PRO A CA  1 
ATOM   2995 C  C   . PRO A 1 414 ? 152.144 141.880 151.834 1.00 82.03 ? 414 PRO A C   1 
ATOM   2996 O  O   . PRO A 1 414 ? 152.657 141.329 152.803 1.00 82.03 ? 414 PRO A O   1 
ATOM   2997 C  CB  . PRO A 1 414 ? 151.801 144.290 152.407 1.00 82.03 ? 414 PRO A CB  1 
ATOM   2998 C  CG  . PRO A 1 414 ? 150.762 145.059 153.123 1.00 82.03 ? 414 PRO A CG  1 
ATOM   2999 C  CD  . PRO A 1 414 ? 150.115 144.036 154.007 1.00 82.03 ? 414 PRO A CD  1 
ATOM   3000 N  N   . PRO A 1 415 ? 152.505 141.598 150.568 1.00 84.92 ? 415 PRO A N   1 
ATOM   3001 C  CA  . PRO A 1 415 ? 153.427 140.490 150.286 1.00 84.92 ? 415 PRO A CA  1 
ATOM   3002 C  C   . PRO A 1 415 ? 154.879 140.944 150.335 1.00 84.92 ? 415 PRO A C   1 
ATOM   3003 O  O   . PRO A 1 415 ? 155.189 142.012 150.849 1.00 84.92 ? 415 PRO A O   1 
ATOM   3004 C  CB  . PRO A 1 415 ? 153.202 140.248 148.796 1.00 84.92 ? 415 PRO A CB  1 
ATOM   3005 C  CG  . PRO A 1 415 ? 152.903 141.607 148.256 1.00 84.92 ? 415 PRO A CG  1 
ATOM   3006 C  CD  . PRO A 1 415 ? 152.192 142.361 149.347 1.00 84.92 ? 415 PRO A CD  1 
ATOM   3007 N  N   . PHE A 1 416 ? 155.777 140.118 149.813 1.00 89.79 ? 416 PHE A N   1 
ATOM   3008 C  CA  . PHE A 1 416 ? 157.194 140.451 149.852 1.00 89.79 ? 416 PHE A CA  1 
ATOM   3009 C  C   . PHE A 1 416 ? 157.761 141.213 148.676 1.00 89.79 ? 416 PHE A C   1 
ATOM   3010 O  O   . PHE A 1 416 ? 158.932 141.587 148.684 1.00 89.79 ? 416 PHE A O   1 
ATOM   3011 C  CB  . PHE A 1 416 ? 157.903 139.112 150.037 1.00 89.79 ? 416 PHE A CB  1 
ATOM   3012 C  CG  . PHE A 1 416 ? 157.278 138.248 151.093 1.00 89.79 ? 416 PHE A CG  1 
ATOM   3013 C  CD1 . PHE A 1 416 ? 157.295 138.640 152.422 1.00 89.79 ? 416 PHE A CD1 1 
ATOM   3014 C  CD2 . PHE A 1 416 ? 156.657 137.057 150.758 1.00 89.79 ? 416 PHE A CD2 1 
ATOM   3015 C  CE1 . PHE A 1 416 ? 156.711 137.857 153.398 1.00 89.79 ? 416 PHE A CE1 1 
ATOM   3016 C  CE2 . PHE A 1 416 ? 156.073 136.268 151.729 1.00 89.79 ? 416 PHE A CE2 1 
ATOM   3017 C  CZ  . PHE A 1 416 ? 156.101 136.668 153.051 1.00 89.79 ? 416 PHE A CZ  1 
ATOM   3018 N  N   . PHE A 1 417 ? 156.941 141.442 147.658 1.00 90.49 ? 417 PHE A N   1 
ATOM   3019 C  CA  . PHE A 1 417 ? 157.384 142.239 146.524 1.00 90.49 ? 417 PHE A CA  1 
ATOM   3020 C  C   . PHE A 1 417 ? 157.362 143.707 146.857 1.00 90.49 ? 417 PHE A C   1 
ATOM   3021 O  O   . PHE A 1 417 ? 158.268 144.447 146.476 1.00 90.49 ? 417 PHE A O   1 
ATOM   3022 C  CB  . PHE A 1 417 ? 156.388 142.131 145.377 1.00 90.49 ? 417 PHE A CB  1 
ATOM   3023 C  CG  . PHE A 1 417 ? 156.036 140.719 145.018 1.00 90.49 ? 417 PHE A CG  1 
ATOM   3024 C  CD1 . PHE A 1 417 ? 157.008 139.847 144.556 1.00 90.49 ? 417 PHE A CD1 1 
ATOM   3025 C  CD2 . PHE A 1 417 ? 154.737 140.260 145.145 1.00 90.49 ? 417 PHE A CD2 1 
ATOM   3026 C  CE1 . PHE A 1 417 ? 156.690 138.544 144.226 1.00 90.49 ? 417 PHE A CE1 1 
ATOM   3027 C  CE2 . PHE A 1 417 ? 154.412 138.958 144.818 1.00 90.49 ? 417 PHE A CE2 1 
ATOM   3028 C  CZ  . PHE A 1 417 ? 155.390 138.099 144.357 1.00 90.49 ? 417 PHE A CZ  1 
ATOM   3029 N  N   . MET A 1 418 ? 156.323 144.143 147.556 1.00 86.68 ? 418 MET A N   1 
ATOM   3030 C  CA  . MET A 1 418 ? 156.277 145.522 148.012 1.00 86.68 ? 418 MET A CA  1 
ATOM   3031 C  C   . MET A 1 418 ? 155.959 145.075 149.437 1.00 86.68 ? 418 MET A C   1 
ATOM   3032 O  O   . MET A 1 418 ? 154.853 144.584 149.680 1.00 86.68 ? 418 MET A O   1 
ATOM   3033 C  CB  . MET A 1 418 ? 155.181 146.393 147.401 1.00 86.68 ? 418 MET A CB  1 
ATOM   3034 C  CG  . MET A 1 418 ? 155.373 146.759 145.935 1.00 86.68 ? 418 MET A CG  1 
ATOM   3035 S  SD  . MET A 1 418 ? 157.088 146.891 145.387 1.00 86.68 ? 418 MET A SD  1 
ATOM   3036 C  CE  . MET A 1 418 ? 157.601 148.448 146.111 1.00 86.68 ? 418 MET A CE  1 
ATOM   3037 N  N   . PRO A 1 419 ? 156.926 145.228 150.406 1.00 86.43 ? 419 PRO A N   1 
ATOM   3038 C  CA  . PRO A 1 419 ? 156.513 144.683 151.691 1.00 86.43 ? 419 PRO A CA  1 
ATOM   3039 C  C   . PRO A 1 419 ? 156.184 145.645 152.809 1.00 86.43 ? 419 PRO A C   1 
ATOM   3040 O  O   . PRO A 1 419 ? 156.586 145.389 153.933 1.00 86.43 ? 419 PRO A O   1 
ATOM   3041 C  CB  . PRO A 1 419 ? 157.617 143.752 152.153 1.00 86.43 ? 419 PRO A CB  1 
ATOM   3042 C  CG  . PRO A 1 419 ? 158.820 144.076 151.312 1.00 86.43 ? 419 PRO A CG  1 
ATOM   3043 C  CD  . PRO A 1 419 ? 158.439 145.195 150.392 1.00 86.43 ? 419 PRO A CD  1 
ATOM   3044 N  N   . SER A 1 420 ? 155.416 146.675 152.535 1.00 80.06 ? 420 SER A N   1 
ATOM   3045 C  CA  . SER A 1 420 ? 155.078 147.618 153.530 1.00 80.06 ? 420 SER A CA  1 
ATOM   3046 C  C   . SER A 1 420 ? 153.739 148.067 153.166 1.00 80.06 ? 420 SER A C   1 
ATOM   3047 O  O   . SER A 1 420 ? 153.168 147.530 152.254 1.00 80.06 ? 420 SER A O   1 
ATOM   3048 C  CB  . SER A 1 420 ? 156.041 148.716 153.206 1.00 80.06 ? 420 SER A CB  1 
ATOM   3049 O  OG  . SER A 1 420 ? 155.837 149.287 151.928 1.00 80.06 ? 420 SER A OG  1 
ATOM   3050 N  N   . TRP A 1 421 ? 153.186 149.026 153.882 1.00 74.07 ? 421 TRP A N   1 
ATOM   3051 C  CA  . TRP A 1 421 ? 151.902 149.531 153.408 1.00 74.07 ? 421 TRP A CA  1 
ATOM   3052 C  C   . TRP A 1 421 ? 152.059 150.618 152.365 1.00 74.07 ? 421 TRP A C   1 
ATOM   3053 O  O   . TRP A 1 421 ? 151.410 150.557 151.318 1.00 74.07 ? 421 TRP A O   1 
ATOM   3054 C  CB  . TRP A 1 421 ? 151.051 150.073 154.551 1.00 74.07 ? 421 TRP A CB  1 
ATOM   3055 C  CG  . TRP A 1 421 ? 150.259 149.049 155.215 1.00 74.07 ? 421 TRP A CG  1 
ATOM   3056 C  CD1 . TRP A 1 421 ? 150.468 148.513 156.442 1.00 74.07 ? 421 TRP A CD1 1 
ATOM   3057 C  CD2 . TRP A 1 421 ? 149.121 148.387 154.668 1.00 74.07 ? 421 TRP A CD2 1 
ATOM   3058 N  NE1 . TRP A 1 421 ? 149.510 147.567 156.709 1.00 74.07 ? 421 TRP A NE1 1 
ATOM   3059 C  CE2 . TRP A 1 421 ? 148.674 147.469 155.627 1.00 74.07 ? 421 TRP A CE2 1 
ATOM   3060 C  CE3 . TRP A 1 421 ? 148.433 148.486 153.456 1.00 74.07 ? 421 TRP A CE3 1 
ATOM   3061 C  CZ2 . TRP A 1 421 ? 147.571 146.653 155.413 1.00 74.07 ? 421 TRP A CZ2 1 
ATOM   3062 C  CZ3 . TRP A 1 421 ? 147.342 147.678 153.245 1.00 74.07 ? 421 TRP A CZ3 1 
ATOM   3063 C  CH2 . TRP A 1 421 ? 146.920 146.775 154.216 1.00 74.07 ? 421 TRP A CH2 1 
ATOM   3064 N  N   . THR A 1 422 ? 152.897 151.619 152.623 1.00 71.02 ? 422 THR A N   1 
ATOM   3065 C  CA  . THR A 1 422 ? 153.025 152.705 151.666 1.00 71.02 ? 422 THR A CA  1 
ATOM   3066 C  C   . THR A 1 422 ? 153.802 152.290 150.431 1.00 71.02 ? 422 THR A C   1 
ATOM   3067 O  O   . THR A 1 422 ? 153.737 152.988 149.417 1.00 71.02 ? 422 THR A O   1 
ATOM   3068 C  CB  . THR A 1 422 ? 153.689 153.908 152.315 1.00 71.02 ? 422 THR A CB  1 
ATOM   3069 O  OG1 . THR A 1 422 ? 154.986 153.533 152.785 1.00 71.02 ? 422 THR A OG1 1 
ATOM   3070 C  CG2 . THR A 1 422 ? 152.856 154.395 153.479 1.00 71.02 ? 422 THR A CG2 1 
ATOM   3071 N  N   . ALA A 1 423 ? 154.509 151.162 150.477 1.00 68.88 ? 423 ALA A N   1 
ATOM   3072 C  CA  . ALA A 1 423 ? 155.170 150.659 149.281 1.00 68.88 ? 423 ALA A CA  1 
ATOM   3073 C  C   . ALA A 1 423 ? 154.182 150.129 148.251 1.00 68.88 ? 423 ALA A C   1 
ATOM   3074 O  O   . ALA A 1 423 ? 154.541 150.010 147.078 1.00 68.88 ? 423 ALA A O   1 
ATOM   3075 C  CB  . ALA A 1 423 ? 156.177 149.571 149.648 1.00 68.88 ? 423 ALA A CB  1 
ATOM   3076 N  N   . MET A 1 424 ? 152.958 149.786 148.654 1.00 66.29 ? 424 MET A N   1 
ATOM   3077 C  CA  . MET A 1 424 ? 151.921 149.546 147.662 1.00 66.29 ? 424 MET A CA  1 
ATOM   3078 C  C   . MET A 1 424 ? 151.473 150.844 147.010 1.00 66.29 ? 424 MET A C   1 
ATOM   3079 O  O   . MET A 1 424 ? 151.321 150.910 145.786 1.00 66.29 ? 424 MET A O   1 
ATOM   3080 C  CB  . MET A 1 424 ? 150.728 148.821 148.275 1.00 66.29 ? 424 MET A CB  1 
ATOM   3081 C  CG  . MET A 1 424 ? 150.895 147.334 148.359 1.00 66.29 ? 424 MET A CG  1 
ATOM   3082 S  SD  . MET A 1 424 ? 149.322 146.562 148.731 1.00 66.29 ? 424 MET A SD  1 
ATOM   3083 C  CE  . MET A 1 424 ? 149.766 144.842 148.588 1.00 66.29 ? 424 MET A CE  1 
ATOM   3084 N  N   . TYR A 1 425 ? 151.264 151.893 147.803 1.00 59.47 ? 425 TYR A N   1 
ATOM   3085 C  CA  . TYR A 1 425 ? 150.729 153.133 147.252 1.00 59.47 ? 425 TYR A CA  1 
ATOM   3086 C  C   . TYR A 1 425 ? 151.712 153.901 146.379 1.00 59.47 ? 425 TYR A C   1 
ATOM   3087 O  O   . TYR A 1 425 ? 151.294 154.871 145.741 1.00 59.47 ? 425 TYR A O   1 
ATOM   3088 C  CB  . TYR A 1 425 ? 150.217 154.041 148.366 1.00 59.47 ? 425 TYR A CB  1 
ATOM   3089 C  CG  . TYR A 1 425 ? 148.828 153.697 148.837 1.00 59.47 ? 425 TYR A CG  1 
ATOM   3090 C  CD1 . TYR A 1 425 ? 148.057 152.780 148.157 1.00 59.47 ? 425 TYR A CD1 1 
ATOM   3091 C  CD2 . TYR A 1 425 ? 148.270 154.332 149.931 1.00 59.47 ? 425 TYR A CD2 1 
ATOM   3092 C  CE1 . TYR A 1 425 ? 146.784 152.479 148.569 1.00 59.47 ? 425 TYR A CE1 1 
ATOM   3093 C  CE2 . TYR A 1 425 ? 146.997 154.039 150.350 1.00 59.47 ? 425 TYR A CE2 1 
ATOM   3094 C  CZ  . TYR A 1 425 ? 146.261 153.111 149.662 1.00 59.47 ? 425 TYR A CZ  1 
ATOM   3095 O  OH  . TYR A 1 425 ? 144.990 152.816 150.070 1.00 59.47 ? 425 TYR A OH  1 
ATOM   3096 N  N   . VAL A 1 426 ? 152.985 153.520 146.325 1.00 59.03 ? 426 VAL A N   1 
ATOM   3097 C  CA  . VAL A 1 426 ? 153.881 154.099 145.331 1.00 59.03 ? 426 VAL A CA  1 
ATOM   3098 C  C   . VAL A 1 426 ? 153.674 153.411 143.987 1.00 59.03 ? 426 VAL A C   1 
ATOM   3099 O  O   . VAL A 1 426 ? 153.693 154.050 142.931 1.00 59.03 ? 426 VAL A O   1 
ATOM   3100 C  CB  . VAL A 1 426 ? 155.339 154.012 145.809 1.00 59.03 ? 426 VAL A CB  1 
ATOM   3101 C  CG1 . VAL A 1 426 ? 156.282 154.618 144.794 1.00 59.03 ? 426 VAL A CG1 1 
ATOM   3102 C  CG2 . VAL A 1 426 ? 155.486 154.721 147.131 1.00 59.03 ? 426 VAL A CG2 1 
ATOM   3103 N  N   . LEU A 1 427 ? 153.431 152.104 144.007 1.00 58.52 ? 427 LEU A N   1 
ATOM   3104 C  CA  . LEU A 1 427 ? 153.107 151.375 142.789 1.00 58.52 ? 427 LEU A CA  1 
ATOM   3105 C  C   . LEU A 1 427 ? 151.623 151.312 142.489 1.00 58.52 ? 427 LEU A C   1 
ATOM   3106 O  O   . LEU A 1 427 ? 151.210 150.461 141.702 1.00 58.52 ? 427 LEU A O   1 
ATOM   3107 C  CB  . LEU A 1 427 ? 153.660 149.950 142.819 1.00 58.52 ? 427 LEU A CB  1 
ATOM   3108 C  CG  . LEU A 1 427 ? 155.019 149.755 142.147 1.00 58.52 ? 427 LEU A CG  1 
ATOM   3109 C  CD1 . LEU A 1 427 ? 156.175 150.173 143.030 1.00 58.52 ? 427 LEU A CD1 1 
ATOM   3110 C  CD2 . LEU A 1 427 ? 155.176 148.334 141.650 1.00 58.52 ? 427 LEU A CD2 1 
ATOM   3111 N  N   . ASN A 1 428 ? 150.807 152.162 143.091 1.00 53.99 ? 428 ASN A N   1 
ATOM   3112 C  CA  . ASN A 1 428 ? 149.453 152.306 142.576 1.00 53.99 ? 428 ASN A CA  1 
ATOM   3113 C  C   . ASN A 1 428 ? 149.198 153.690 142.007 1.00 53.99 ? 428 ASN A C   1 
ATOM   3114 O  O   . ASN A 1 428 ? 148.445 153.825 141.039 1.00 53.99 ? 428 ASN A O   1 
ATOM   3115 C  CB  . ASN A 1 428 ? 148.416 151.992 143.653 1.00 53.99 ? 428 ASN A CB  1 
ATOM   3116 C  CG  . ASN A 1 428 ? 148.445 150.551 144.082 1.00 53.99 ? 428 ASN A CG  1 
ATOM   3117 O  OD1 . ASN A 1 428 ? 148.589 150.247 145.258 1.00 53.99 ? 428 ASN A OD1 1 
ATOM   3118 N  ND2 . ASN A 1 428 ? 148.343 149.651 143.122 1.00 53.99 ? 428 ASN A ND2 1 
ATOM   3119 N  N   . ALA A 1 429 ? 149.791 154.723 142.591 1.00 53.05 ? 429 ALA A N   1 
ATOM   3120 C  CA  . ALA A 1 429 ? 149.749 156.041 141.985 1.00 53.05 ? 429 ALA A CA  1 
ATOM   3121 C  C   . ALA A 1 429 ? 150.738 156.182 140.846 1.00 53.05 ? 429 ALA A C   1 
ATOM   3122 O  O   . ALA A 1 429 ? 150.643 157.144 140.083 1.00 53.05 ? 429 ALA A O   1 
ATOM   3123 C  CB  . ALA A 1 429 ? 150.012 157.120 143.036 1.00 53.05 ? 429 ALA A CB  1 
ATOM   3124 N  N   . PHE A 1 430 ? 151.698 155.266 140.722 1.00 50.79 ? 430 PHE A N   1 
ATOM   3125 C  CA  . PHE A 1 430 ? 152.465 155.215 139.489 1.00 50.79 ? 430 PHE A CA  1 
ATOM   3126 C  C   . PHE A 1 430 ? 151.593 154.772 138.335 1.00 50.79 ? 430 PHE A C   1 
ATOM   3127 O  O   . PHE A 1 430 ? 151.696 155.325 137.239 1.00 50.79 ? 430 PHE A O   1 
ATOM   3128 C  CB  . PHE A 1 430 ? 153.656 154.269 139.613 1.00 50.79 ? 430 PHE A CB  1 
ATOM   3129 C  CG  . PHE A 1 430 ? 154.450 154.136 138.342 1.00 50.79 ? 430 PHE A CG  1 
ATOM   3130 C  CD1 . PHE A 1 430 ? 155.294 155.150 137.933 1.00 50.79 ? 430 PHE A CD1 1 
ATOM   3131 C  CD2 . PHE A 1 430 ? 154.347 153.003 137.551 1.00 50.79 ? 430 PHE A CD2 1 
ATOM   3132 C  CE1 . PHE A 1 430 ? 156.021 155.037 136.766 1.00 50.79 ? 430 PHE A CE1 1 
ATOM   3133 C  CE2 . PHE A 1 430 ? 155.069 152.891 136.383 1.00 50.79 ? 430 PHE A CE2 1 
ATOM   3134 C  CZ  . PHE A 1 430 ? 155.905 153.906 135.995 1.00 50.79 ? 430 PHE A CZ  1 
ATOM   3135 N  N   . VAL A 1 431 ? 150.715 153.800 138.565 1.00 48.97 ? 431 VAL A N   1 
ATOM   3136 C  CA  . VAL A 1 431 ? 149.972 153.196 137.467 1.00 48.97 ? 431 VAL A CA  1 
ATOM   3137 C  C   . VAL A 1 431 ? 148.860 154.121 136.989 1.00 48.97 ? 431 VAL A C   1 
ATOM   3138 O  O   . VAL A 1 431 ? 148.607 154.230 135.789 1.00 48.97 ? 431 VAL A O   1 
ATOM   3139 C  CB  . VAL A 1 431 ? 149.438 151.825 137.900 1.00 48.97 ? 431 VAL A CB  1 
ATOM   3140 C  CG1 . VAL A 1 431 ? 148.696 151.151 136.776 1.00 48.97 ? 431 VAL A CG1 1 
ATOM   3141 C  CG2 . VAL A 1 431 ? 150.575 150.973 138.384 1.00 48.97 ? 431 VAL A CG2 1 
ATOM   3142 N  N   . VAL A 1 432 ? 148.200 154.830 137.906 1.00 46.22 ? 432 VAL A N   1 
ATOM   3143 C  CA  . VAL A 1 432 ? 147.145 155.757 137.503 1.00 46.22 ? 432 VAL A CA  1 
ATOM   3144 C  C   . VAL A 1 432 ? 147.723 156.958 136.758 1.00 46.22 ? 432 VAL A C   1 
ATOM   3145 O  O   . VAL A 1 432 ? 147.111 157.470 135.818 1.00 46.22 ? 432 VAL A O   1 
ATOM   3146 C  CB  . VAL A 1 432 ? 146.334 156.170 138.744 1.00 46.22 ? 432 VAL A CB  1 
ATOM   3147 C  CG1 . VAL A 1 432 ? 145.243 157.169 138.411 1.00 46.22 ? 432 VAL A CG1 1 
ATOM   3148 C  CG2 . VAL A 1 432 ? 145.739 154.948 139.396 1.00 46.22 ? 432 VAL A CG2 1 
ATOM   3149 N  N   . VAL A 1 433 ? 148.930 157.389 137.113 1.00 45.17 ? 433 VAL A N   1 
ATOM   3150 C  CA  . VAL A 1 433 ? 149.529 158.535 136.440 1.00 45.17 ? 433 VAL A CA  1 
ATOM   3151 C  C   . VAL A 1 433 ? 150.129 158.119 135.103 1.00 45.17 ? 433 VAL A C   1 
ATOM   3152 O  O   . VAL A 1 433 ? 149.983 158.824 134.099 1.00 45.17 ? 433 VAL A O   1 
ATOM   3153 C  CB  . VAL A 1 433 ? 150.558 159.211 137.361 1.00 45.17 ? 433 VAL A CB  1 
ATOM   3154 C  CG1 . VAL A 1 433 ? 151.374 160.242 136.617 1.00 45.17 ? 433 VAL A CG1 1 
ATOM   3155 C  CG2 . VAL A 1 433 ? 149.829 159.892 138.495 1.00 45.17 ? 433 VAL A CG2 1 
ATOM   3156 N  N   . TRP A 1 434 ? 150.781 156.958 135.054 1.00 42.71 ? 434 TRP A N   1 
ATOM   3157 C  CA  . TRP A 1 434 ? 151.377 156.503 133.800 1.00 42.71 ? 434 TRP A CA  1 
ATOM   3158 C  C   . TRP A 1 434 ? 150.337 156.155 132.750 1.00 42.71 ? 434 TRP A C   1 
ATOM   3159 O  O   . TRP A 1 434 ? 150.520 156.493 131.580 1.00 42.71 ? 434 TRP A O   1 
ATOM   3160 C  CB  . TRP A 1 434 ? 152.261 155.280 134.014 1.00 42.71 ? 434 TRP A CB  1 
ATOM   3161 C  CG  . TRP A 1 434 ? 152.927 154.801 132.761 1.00 42.71 ? 434 TRP A CG  1 
ATOM   3162 C  CD1 . TRP A 1 434 ? 152.486 153.827 131.920 1.00 42.71 ? 434 TRP A CD1 1 
ATOM   3163 C  CD2 . TRP A 1 434 ? 154.179 155.239 132.238 1.00 42.71 ? 434 TRP A CD2 1 
ATOM   3164 N  NE1 . TRP A 1 434 ? 153.366 153.657 130.887 1.00 42.71 ? 434 TRP A NE1 1 
ATOM   3165 C  CE2 . TRP A 1 434 ? 154.420 154.509 131.064 1.00 42.71 ? 434 TRP A CE2 1 
ATOM   3166 C  CE3 . TRP A 1 434 ? 155.115 156.190 132.641 1.00 42.71 ? 434 TRP A CE3 1 
ATOM   3167 C  CZ2 . TRP A 1 434 ? 155.556 154.697 130.296 1.00 42.71 ? 434 TRP A CZ2 1 
ATOM   3168 C  CZ3 . TRP A 1 434 ? 156.239 156.373 131.879 1.00 42.71 ? 434 TRP A CZ3 1 
ATOM   3169 C  CH2 . TRP A 1 434 ? 156.452 155.631 130.721 1.00 42.71 ? 434 TRP A CH2 1 
ATOM   3170 N  N   . VAL A 1 435 ? 149.261 155.481 133.125 1.00 43.31 ? 435 VAL A N   1 
ATOM   3171 C  CA  . VAL A 1 435 ? 148.300 155.033 132.128 1.00 43.31 ? 435 VAL A CA  1 
ATOM   3172 C  C   . VAL A 1 435 ? 147.387 156.172 131.659 1.00 43.31 ? 435 VAL A C   1 
ATOM   3173 O  O   . VAL A 1 435 ? 146.926 156.172 130.518 1.00 43.31 ? 435 VAL A O   1 
ATOM   3174 C  CB  . VAL A 1 435 ? 147.534 153.830 132.708 1.00 43.31 ? 435 VAL A CB  1 
ATOM   3175 C  CG1 . VAL A 1 435 ? 146.452 153.338 131.808 1.00 43.31 ? 435 VAL A CG1 1 
ATOM   3176 C  CG2 . VAL A 1 435 ? 148.504 152.694 132.931 1.00 43.31 ? 435 VAL A CG2 1 
ATOM   3177 N  N   . LEU A 1 436 ? 147.188 157.206 132.456 1.00 40.72 ? 436 LEU A N   1 
ATOM   3178 C  CA  . LEU A 1 436 ? 146.435 158.359 131.972 1.00 40.72 ? 436 LEU A CA  1 
ATOM   3179 C  C   . LEU A 1 436 ? 147.266 159.336 131.156 1.00 40.72 ? 436 LEU A C   1 
ATOM   3180 O  O   . LEU A 1 436 ? 146.768 160.410 130.832 1.00 40.72 ? 436 LEU A O   1 
ATOM   3181 C  CB  . LEU A 1 436 ? 145.778 159.096 133.138 1.00 40.72 ? 436 LEU A CB  1 
ATOM   3182 C  CG  . LEU A 1 436 ? 144.282 158.885 133.345 1.00 40.72 ? 436 LEU A CG  1 
ATOM   3183 C  CD1 . LEU A 1 436 ? 143.561 159.648 132.283 1.00 40.72 ? 436 LEU A CD1 1 
ATOM   3184 C  CD2 . LEU A 1 436 ? 143.903 157.444 133.237 1.00 40.72 ? 436 LEU A CD2 1 
ATOM   3185 N  N   . ILE A 1 437 ? 148.508 159.024 130.822 1.00 41.03 ? 437 ILE A N   1 
ATOM   3186 C  CA  . ILE A 1 437 ? 149.338 159.888 129.996 1.00 41.03 ? 437 ILE A CA  1 
ATOM   3187 C  C   . ILE A 1 437 ? 149.850 159.156 128.760 1.00 41.03 ? 437 ILE A C   1 
ATOM   3188 O  O   . ILE A 1 437 ? 149.794 159.680 127.645 1.00 41.03 ? 437 ILE A O   1 
ATOM   3189 C  CB  . ILE A 1 437 ? 150.499 160.492 130.813 1.00 41.03 ? 437 ILE A CB  1 
ATOM   3190 C  CG1 . ILE A 1 437 ? 149.940 161.449 131.864 1.00 41.03 ? 437 ILE A CG1 1 
ATOM   3191 C  CG2 . ILE A 1 437 ? 151.491 161.213 129.930 1.00 41.03 ? 437 ILE A CG2 1 
ATOM   3192 C  CD1 . ILE A 1 437 ? 150.957 161.928 132.855 1.00 41.03 ? 437 ILE A CD1 1 
ATOM   3193 N  N   . VAL A 1 438 ? 150.319 157.923 128.932 1.00 39.55 ? 438 VAL A N   1 
ATOM   3194 C  CA  . VAL A 1 438 ? 150.802 157.153 127.794 1.00 39.55 ? 438 VAL A CA  1 
ATOM   3195 C  C   . VAL A 1 438 ? 149.697 156.252 127.231 1.00 39.55 ? 438 VAL A C   1 
ATOM   3196 O  O   . VAL A 1 438 ? 149.815 155.734 126.115 1.00 39.55 ? 438 VAL A O   1 
ATOM   3197 C  CB  . VAL A 1 438 ? 152.079 156.442 128.279 1.00 39.55 ? 438 VAL A CB  1 
ATOM   3198 C  CG1 . VAL A 1 438 ? 152.803 155.691 127.172 1.00 39.55 ? 438 VAL A CG1 1 
ATOM   3199 C  CG2 . VAL A 1 438 ? 153.010 157.464 128.870 1.00 39.55 ? 438 VAL A CG2 1 
ATOM   3200 N  N   . GLY A 1 439 ? 148.585 156.124 127.935 1.00 39.84 ? 439 GLY A N   1 
ATOM   3201 C  CA  . GLY A 1 439 ? 147.439 155.368 127.475 1.00 39.84 ? 439 GLY A CA  1 
ATOM   3202 C  C   . GLY A 1 439 ? 146.395 156.313 126.931 1.00 39.84 ? 439 GLY A C   1 
ATOM   3203 O  O   . GLY A 1 439 ? 146.445 156.671 125.759 1.00 39.84 ? 439 GLY A O   1 
ATOM   3204 N  N   . PHE A 1 440 ? 145.435 156.715 127.760 1.00 41.22 ? 440 PHE A N   1 
ATOM   3205 C  CA  . PHE A 1 440 ? 144.409 157.704 127.430 1.00 41.22 ? 440 PHE A CA  1 
ATOM   3206 C  C   . PHE A 1 440 ? 144.967 159.068 126.992 1.00 41.22 ? 440 PHE A C   1 
ATOM   3207 O  O   . PHE A 1 440 ? 144.248 159.826 126.339 1.00 41.22 ? 440 PHE A O   1 
ATOM   3208 C  CB  . PHE A 1 440 ? 143.486 157.876 128.639 1.00 41.22 ? 440 PHE A CB  1 
ATOM   3209 C  CG  . PHE A 1 440 ? 142.343 158.807 128.409 1.00 41.22 ? 440 PHE A CG  1 
ATOM   3210 C  CD1 . PHE A 1 440 ? 141.255 158.409 127.668 1.00 41.22 ? 440 PHE A CD1 1 
ATOM   3211 C  CD2 . PHE A 1 440 ? 142.370 160.093 128.913 1.00 41.22 ? 440 PHE A CD2 1 
ATOM   3212 C  CE1 . PHE A 1 440 ? 140.207 159.272 127.447 1.00 41.22 ? 440 PHE A CE1 1 
ATOM   3213 C  CE2 . PHE A 1 440 ? 141.327 160.957 128.696 1.00 41.22 ? 440 PHE A CE2 1 
ATOM   3214 C  CZ  . PHE A 1 440 ? 140.245 160.549 127.961 1.00 41.22 ? 440 PHE A CZ  1 
ATOM   3215 N  N   . GLY A 1 441 ? 146.234 159.373 127.238 1.00 41.46 ? 441 GLY A N   1 
ATOM   3216 C  CA  . GLY A 1 441 ? 146.780 160.691 126.976 1.00 41.46 ? 441 GLY A CA  1 
ATOM   3217 C  C   . GLY A 1 441 ? 147.355 160.808 125.581 1.00 41.46 ? 441 GLY A C   1 
ATOM   3218 O  O   . GLY A 1 441 ? 146.607 161.122 124.653 1.00 41.46 ? 441 GLY A O   1 
ATOM   3219 N  N   . PHE A 1 442 ? 148.680 160.664 125.440 1.00 39.03 ? 442 PHE A N   1 
ATOM   3220 C  CA  . PHE A 1 442 ? 149.305 160.625 124.118 1.00 39.03 ? 442 PHE A CA  1 
ATOM   3221 C  C   . PHE A 1 442 ? 148.702 159.543 123.234 1.00 39.03 ? 442 PHE A C   1 
ATOM   3222 O  O   . PHE A 1 442 ? 148.348 159.797 122.080 1.00 39.03 ? 442 PHE A O   1 
ATOM   3223 C  CB  . PHE A 1 442 ? 150.806 160.393 124.235 1.00 39.03 ? 442 PHE A CB  1 
ATOM   3224 C  CG  . PHE A 1 442 ? 151.585 161.604 124.591 1.00 39.03 ? 442 PHE A CG  1 
ATOM   3225 C  CD1 . PHE A 1 442 ? 151.868 162.557 123.633 1.00 39.03 ? 442 PHE A CD1 1 
ATOM   3226 C  CD2 . PHE A 1 442 ? 152.076 161.771 125.868 1.00 39.03 ? 442 PHE A CD2 1 
ATOM   3227 C  CE1 . PHE A 1 442 ? 152.603 163.672 123.953 1.00 39.03 ? 442 PHE A CE1 1 
ATOM   3228 C  CE2 . PHE A 1 442 ? 152.815 162.881 126.198 1.00 39.03 ? 442 PHE A CE2 1 
ATOM   3229 C  CZ  . PHE A 1 442 ? 153.078 163.836 125.239 1.00 39.03 ? 442 PHE A CZ  1 
ATOM   3230 N  N   . GLY A 1 443 ? 148.576 158.327 123.759 1.00 38.09 ? 443 GLY A N   1 
ATOM   3231 C  CA  . GLY A 1 443 ? 148.067 157.226 122.964 1.00 38.09 ? 443 GLY A CA  1 
ATOM   3232 C  C   . GLY A 1 443 ? 146.595 157.323 122.641 1.00 38.09 ? 443 GLY A C   1 
ATOM   3233 O  O   . GLY A 1 443 ? 146.111 156.563 121.802 1.00 38.09 ? 443 GLY A O   1 
ATOM   3234 N  N   . GLY A 1 444 ? 145.865 158.214 123.313 1.00 37.99 ? 444 GLY A N   1 
ATOM   3235 C  CA  . GLY A 1 444 ? 144.494 158.485 122.919 1.00 37.99 ? 444 GLY A CA  1 
ATOM   3236 C  C   . GLY A 1 444 ? 144.416 159.490 121.790 1.00 37.99 ? 444 GLY A C   1 
ATOM   3237 O  O   . GLY A 1 444 ? 143.567 159.380 120.906 1.00 37.99 ? 444 GLY A O   1 
ATOM   3238 N  N   . TRP A 1 445 ? 145.310 160.479 121.801 1.00 37.45 ? 445 TRP A N   1 
ATOM   3239 C  CA  . TRP A 1 445 ? 145.407 161.422 120.695 1.00 37.45 ? 445 TRP A CA  1 
ATOM   3240 C  C   . TRP A 1 445 ? 145.910 160.744 119.434 1.00 37.45 ? 445 TRP A C   1 
ATOM   3241 O  O   . TRP A 1 445 ? 145.312 160.887 118.364 1.00 37.45 ? 445 TRP A O   1 
ATOM   3242 C  CB  . TRP A 1 445 ? 146.349 162.554 121.058 1.00 37.45 ? 445 TRP A CB  1 
ATOM   3243 C  CG  . TRP A 1 445 ? 146.562 163.489 119.949 1.00 37.45 ? 445 TRP A CG  1 
ATOM   3244 C  CD1 . TRP A 1 445 ? 145.692 164.416 119.485 1.00 37.45 ? 445 TRP A CD1 1 
ATOM   3245 C  CD2 . TRP A 1 445 ? 147.712 163.565 119.116 1.00 37.45 ? 445 TRP A CD2 1 
ATOM   3246 N  NE1 . TRP A 1 445 ? 146.241 165.096 118.432 1.00 37.45 ? 445 TRP A NE1 1 
ATOM   3247 C  CE2 . TRP A 1 445 ? 147.484 164.585 118.184 1.00 37.45 ? 445 TRP A CE2 1 
ATOM   3248 C  CE3 . TRP A 1 445 ? 148.920 162.874 119.076 1.00 37.45 ? 445 TRP A CE3 1 
ATOM   3249 C  CZ2 . TRP A 1 445 ? 148.416 164.931 117.227 1.00 37.45 ? 445 TRP A CZ2 1 
ATOM   3250 C  CZ3 . TRP A 1 445 ? 149.846 163.221 118.129 1.00 37.45 ? 445 TRP A CZ3 1 
ATOM   3251 C  CH2 . TRP A 1 445 ? 149.592 164.237 117.215 1.00 37.45 ? 445 TRP A CH2 1 
ATOM   3252 N  N   . ALA A 1 446 ? 147.014 160.001 119.540 1.00 37.99 ? 446 ALA A N   1 
ATOM   3253 C  CA  . ALA A 1 446 ? 147.677 159.468 118.357 1.00 37.99 ? 446 ALA A CA  1 
ATOM   3254 C  C   . ALA A 1 446 ? 146.880 158.357 117.685 1.00 37.99 ? 446 ALA A C   1 
ATOM   3255 O  O   . ALA A 1 446 ? 146.884 158.263 116.455 1.00 37.99 ? 446 ALA A O   1 
ATOM   3256 C  CB  . ALA A 1 446 ? 149.062 158.966 118.726 1.00 37.99 ? 446 ALA A CB  1 
ATOM   3257 N  N   . SER A 1 447 ? 146.168 157.534 118.455 1.00 39.99 ? 447 SER A N   1 
ATOM   3258 C  CA  . SER A 1 447 ? 145.385 156.454 117.860 1.00 39.99 ? 447 SER A CA  1 
ATOM   3259 C  C   . SER A 1 447 ? 144.137 156.977 117.177 1.00 39.99 ? 447 SER A C   1 
ATOM   3260 O  O   . SER A 1 447 ? 143.498 156.253 116.411 1.00 39.99 ? 447 SER A O   1 
ATOM   3261 C  CB  . SER A 1 447 ? 144.993 155.443 118.920 1.00 39.99 ? 447 SER A CB  1 
ATOM   3262 O  OG  . SER A 1 447 ? 146.134 154.878 119.525 1.00 39.99 ? 447 SER A OG  1 
ATOM   3263 N  N   . VAL A 1 448 ? 143.738 158.208 117.486 1.00 40.13 ? 448 VAL A N   1 
ATOM   3264 C  CA  . VAL A 1 448 ? 142.611 158.813 116.793 1.00 40.13 ? 448 VAL A CA  1 
ATOM   3265 C  C   . VAL A 1 448 ? 143.080 159.507 115.518 1.00 40.13 ? 448 VAL A C   1 
ATOM   3266 O  O   . VAL A 1 448 ? 142.393 159.468 114.494 1.00 40.13 ? 448 VAL A O   1 
ATOM   3267 C  CB  . VAL A 1 448 ? 141.856 159.745 117.760 1.00 40.13 ? 448 VAL A CB  1 
ATOM   3268 C  CG1 . VAL A 1 448 ? 140.850 160.617 117.052 1.00 40.13 ? 448 VAL A CG1 1 
ATOM   3269 C  CG2 . VAL A 1 448 ? 141.116 158.911 118.782 1.00 40.13 ? 448 VAL A CG2 1 
ATOM   3270 N  N   . THR A 1 449 ? 144.279 160.096 115.537 1.00 40.86 ? 449 THR A N   1 
ATOM   3271 C  CA  . THR A 1 449 ? 144.831 160.710 114.331 1.00 40.86 ? 449 THR A CA  1 
ATOM   3272 C  C   . THR A 1 449 ? 145.095 159.664 113.254 1.00 40.86 ? 449 THR A C   1 
ATOM   3273 O  O   . THR A 1 449 ? 144.825 159.892 112.070 1.00 40.86 ? 449 THR A O   1 
ATOM   3274 C  CB  . THR A 1 449 ? 146.113 161.470 114.665 1.00 40.86 ? 449 THR A CB  1 
ATOM   3275 O  OG1 . THR A 1 449 ? 145.825 162.463 115.647 1.00 40.86 ? 449 THR A OG1 1 
ATOM   3276 C  CG2 . THR A 1 449 ? 146.665 162.171 113.457 1.00 40.86 ? 449 THR A CG2 1 
ATOM   3277 N  N   . ASN A 1 450 ? 145.572 158.488 113.653 1.00 43.32 ? 450 ASN A N   1 
ATOM   3278 C  CA  . ASN A 1 450 ? 145.840 157.427 112.690 1.00 43.32 ? 450 ASN A CA  1 
ATOM   3279 C  C   . ASN A 1 450 ? 144.562 156.738 112.227 1.00 43.32 ? 450 ASN A C   1 
ATOM   3280 O  O   . ASN A 1 450 ? 144.502 156.264 111.093 1.00 43.32 ? 450 ASN A O   1 
ATOM   3281 C  CB  . ASN A 1 450 ? 146.797 156.424 113.318 1.00 43.32 ? 450 ASN A CB  1 
ATOM   3282 C  CG  . ASN A 1 450 ? 147.501 155.561 112.312 1.00 43.32 ? 450 ASN A CG  1 
ATOM   3283 O  OD1 . ASN A 1 450 ? 147.293 155.669 111.110 1.00 43.32 ? 450 ASN A OD1 1 
ATOM   3284 N  ND2 . ASN A 1 450 ? 148.374 154.703 112.806 1.00 43.32 ? 450 ASN A ND2 1 
ATOM   3285 N  N   . PHE A 1 451 ? 143.539 156.680 113.075 1.00 45.90 ? 451 PHE A N   1 
ATOM   3286 C  CA  . PHE A 1 451 ? 142.251 156.142 112.661 1.00 45.90 ? 451 PHE A CA  1 
ATOM   3287 C  C   . PHE A 1 451 ? 141.562 157.072 111.681 1.00 45.90 ? 451 PHE A C   1 
ATOM   3288 O  O   . PHE A 1 451 ? 140.945 156.611 110.720 1.00 45.90 ? 451 PHE A O   1 
ATOM   3289 C  CB  . PHE A 1 451 ? 141.372 155.920 113.890 1.00 45.90 ? 451 PHE A CB  1 
ATOM   3290 C  CG  . PHE A 1 451 ? 140.043 155.304 113.593 1.00 45.90 ? 451 PHE A CG  1 
ATOM   3291 C  CD1 . PHE A 1 451 ? 139.920 153.946 113.383 1.00 45.90 ? 451 PHE A CD1 1 
ATOM   3292 C  CD2 . PHE A 1 451 ? 138.909 156.086 113.549 1.00 45.90 ? 451 PHE A CD2 1 
ATOM   3293 C  CE1 . PHE A 1 451 ? 138.689 153.381 113.127 1.00 45.90 ? 451 PHE A CE1 1 
ATOM   3294 C  CE2 . PHE A 1 451 ? 137.682 155.530 113.284 1.00 45.90 ? 451 PHE A CE2 1 
ATOM   3295 C  CZ  . PHE A 1 451 ? 137.572 154.177 113.074 1.00 45.90 ? 451 PHE A CZ  1 
ATOM   3296 N  N   . VAL A 1 452 ? 141.651 158.378 111.914 1.00 47.27 ? 452 VAL A N   1 
ATOM   3297 C  CA  . VAL A 1 452 ? 141.049 159.361 111.021 1.00 47.27 ? 452 VAL A CA  1 
ATOM   3298 C  C   . VAL A 1 452 ? 141.760 159.410 109.672 1.00 47.27 ? 452 VAL A C   1 
ATOM   3299 O  O   . VAL A 1 452 ? 141.098 159.464 108.631 1.00 47.27 ? 452 VAL A O   1 
ATOM   3300 C  CB  . VAL A 1 452 ? 141.029 160.734 111.718 1.00 47.27 ? 452 VAL A CB  1 
ATOM   3301 C  CG1 . VAL A 1 452 ? 140.769 161.860 110.748 1.00 47.27 ? 452 VAL A CG1 1 
ATOM   3302 C  CG2 . VAL A 1 452 ? 139.943 160.750 112.760 1.00 47.27 ? 452 VAL A CG2 1 
ATOM   3303 N  N   . ARG A 1 453 ? 143.093 159.321 109.658 1.00 49.19 ? 453 ARG A N   1 
ATOM   3304 C  CA  . ARG A 1 453 ? 143.813 159.395 108.392 1.00 49.19 ? 453 ARG A CA  1 
ATOM   3305 C  C   . ARG A 1 453 ? 143.643 158.135 107.553 1.00 49.19 ? 453 ARG A C   1 
ATOM   3306 O  O   . ARG A 1 453 ? 143.894 158.167 106.344 1.00 49.19 ? 453 ARG A O   1 
ATOM   3307 C  CB  . ARG A 1 453 ? 145.294 159.688 108.626 1.00 49.19 ? 453 ARG A CB  1 
ATOM   3308 C  CG  . ARG A 1 453 ? 145.523 161.101 109.087 1.00 49.19 ? 453 ARG A CG  1 
ATOM   3309 C  CD  . ARG A 1 453 ? 146.978 161.526 109.018 1.00 49.19 ? 453 ARG A CD  1 
ATOM   3310 N  NE  . ARG A 1 453 ? 147.862 160.855 109.965 1.00 49.19 ? 453 ARG A NE  1 
ATOM   3311 C  CZ  . ARG A 1 453 ? 149.178 161.041 109.998 1.00 49.19 ? 453 ARG A CZ  1 
ATOM   3312 N  NH1 . ARG A 1 453 ? 149.752 161.869 109.145 1.00 49.19 ? 453 ARG A NH1 1 
ATOM   3313 N  NH2 . ARG A 1 453 ? 149.920 160.403 110.879 1.00 49.19 ? 453 ARG A NH2 1 
ATOM   3314 N  N   . GLN A 1 454 ? 143.219 157.023 108.154 1.00 50.44 ? 454 GLN A N   1 
ATOM   3315 C  CA  . GLN A 1 454 ? 142.841 155.876 107.342 1.00 50.44 ? 454 GLN A CA  1 
ATOM   3316 C  C   . GLN A 1 454 ? 141.567 156.154 106.568 1.00 50.44 ? 454 GLN A C   1 
ATOM   3317 O  O   . GLN A 1 454 ? 141.371 155.603 105.483 1.00 50.44 ? 454 GLN A O   1 
ATOM   3318 C  CB  . GLN A 1 454 ? 142.657 154.633 108.209 1.00 50.44 ? 454 GLN A CB  1 
ATOM   3319 C  CG  . GLN A 1 454 ? 143.920 154.042 108.807 1.00 50.44 ? 454 GLN A CG  1 
ATOM   3320 C  CD  . GLN A 1 454 ? 144.768 153.330 107.799 1.00 50.44 ? 454 GLN A CD  1 
ATOM   3321 O  OE1 . GLN A 1 454 ? 144.260 152.627 106.934 1.00 50.44 ? 454 GLN A OE1 1 
ATOM   3322 N  NE2 . GLN A 1 454 ? 146.072 153.500 107.903 1.00 50.44 ? 454 GLN A NE2 1 
ATOM   3323 N  N   . VAL A 1 455 ? 140.689 157.004 107.101 1.00 54.23 ? 455 VAL A N   1 
ATOM   3324 C  CA  . VAL A 1 455 ? 139.450 157.327 106.402 1.00 54.23 ? 455 VAL A CA  1 
ATOM   3325 C  C   . VAL A 1 455 ? 139.727 158.272 105.239 1.00 54.23 ? 455 VAL A C   1 
ATOM   3326 O  O   . VAL A 1 455 ? 139.152 158.129 104.155 1.00 54.23 ? 455 VAL A O   1 
ATOM   3327 C  CB  . VAL A 1 455 ? 138.423 157.914 107.385 1.00 54.23 ? 455 VAL A CB  1 
ATOM   3328 C  CG1 . VAL A 1 455 ? 137.165 158.304 106.666 1.00 54.23 ? 455 VAL A CG1 1 
ATOM   3329 C  CG2 . VAL A 1 455 ? 138.098 156.913 108.460 1.00 54.23 ? 455 VAL A CG2 1 
ATOM   3330 N  N   . ASP A 1 456 ? 140.656 159.216 105.419 1.00 58.38 ? 456 ASP A N   1 
ATOM   3331 C  CA  . ASP A 1 456 ? 140.971 160.142 104.336 1.00 58.38 ? 456 ASP A CA  1 
ATOM   3332 C  C   . ASP A 1 456 ? 141.795 159.485 103.236 1.00 58.38 ? 456 ASP A C   1 
ATOM   3333 O  O   . ASP A 1 456 ? 141.961 160.065 102.159 1.00 58.38 ? 456 ASP A O   1 
ATOM   3334 C  CB  . ASP A 1 456 ? 141.689 161.369 104.877 1.00 58.38 ? 456 ASP A CB  1 
ATOM   3335 C  CG  . ASP A 1 456 ? 140.765 162.266 105.659 1.00 58.38 ? 456 ASP A CG  1 
ATOM   3336 O  OD1 . ASP A 1 456 ? 139.548 162.228 105.387 1.00 58.38 ? 456 ASP A OD1 1 
ATOM   3337 O  OD2 . ASP A 1 456 ? 141.245 163.019 106.532 1.00 58.38 ? 456 ASP A OD2 1 
ATOM   3338 N  N   . THR A 1 457 ? 142.319 158.286 103.475 1.00 56.62 ? 457 THR A N   1 
ATOM   3339 C  CA  . THR A 1 457 ? 142.906 157.532 102.378 1.00 56.62 ? 457 THR A CA  1 
ATOM   3340 C  C   . THR A 1 457 ? 141.872 156.643 101.696 1.00 56.62 ? 457 THR A C   1 
ATOM   3341 O  O   . THR A 1 457 ? 141.571 156.837 100.516 1.00 56.62 ? 457 THR A O   1 
ATOM   3342 C  CB  . THR A 1 457 ? 144.073 156.690 102.881 1.00 56.62 ? 457 THR A CB  1 
ATOM   3343 O  OG1 . THR A 1 457 ? 145.058 157.541 103.473 1.00 56.62 ? 457 THR A OG1 1 
ATOM   3344 C  CG2 . THR A 1 457 ? 144.702 155.937 101.733 1.00 56.62 ? 457 THR A CG2 1 
ATOM   3345 N  N   . PHE A 1 458 ? 141.296 155.689 102.430 1.00 55.62 ? 458 PHE A N   1 
ATOM   3346 C  CA  . PHE A 1 458 ? 140.466 154.638 101.858 1.00 55.62 ? 458 PHE A CA  1 
ATOM   3347 C  C   . PHE A 1 458 ? 138.987 154.966 101.794 1.00 55.62 ? 458 PHE A C   1 
ATOM   3348 O  O   . PHE A 1 458 ? 138.268 154.324 101.030 1.00 55.62 ? 458 PHE A O   1 
ATOM   3349 C  CB  . PHE A 1 458 ? 140.626 153.340 102.651 1.00 55.62 ? 458 PHE A CB  1 
ATOM   3350 C  CG  . PHE A 1 458 ? 141.965 152.716 102.511 1.00 55.62 ? 458 PHE A CG  1 
ATOM   3351 C  CD1 . PHE A 1 458 ? 142.252 151.902 101.437 1.00 55.62 ? 458 PHE A CD1 1 
ATOM   3352 C  CD2 . PHE A 1 458 ? 142.945 152.946 103.454 1.00 55.62 ? 458 PHE A CD2 1 
ATOM   3353 C  CE1 . PHE A 1 458 ? 143.496 151.322 101.308 1.00 55.62 ? 458 PHE A CE1 1 
ATOM   3354 C  CE2 . PHE A 1 458 ? 144.188 152.377 103.330 1.00 55.62 ? 458 PHE A CE2 1 
ATOM   3355 C  CZ  . PHE A 1 458 ? 144.464 151.565 102.255 1.00 55.62 ? 458 PHE A CZ  1 
ATOM   3356 N  N   . GLY A 1 459 ? 138.500 155.915 102.582 1.00 56.81 ? 459 GLY A N   1 
ATOM   3357 C  CA  . GLY A 1 459 ? 137.090 156.252 102.521 1.00 56.81 ? 459 GLY A CA  1 
ATOM   3358 C  C   . GLY A 1 459 ? 136.205 155.329 103.332 1.00 56.81 ? 459 GLY A C   1 
ATOM   3359 O  O   . GLY A 1 459 ? 136.539 154.156 103.529 1.00 56.81 ? 459 GLY A O   1 
ATOM   3360 N  N   . LEU A 1 460 ? 135.074 155.848 103.806 1.00 56.18 ? 460 LEU A N   1 
ATOM   3361 C  CA  . LEU A 1 460 ? 134.144 155.067 104.606 1.00 56.18 ? 460 LEU A CA  1 
ATOM   3362 C  C   . LEU A 1 460 ? 133.485 153.991 103.751 1.00 56.18 ? 460 LEU A C   1 
ATOM   3363 O  O   . LEU A 1 460 ? 133.398 154.113 102.527 1.00 56.18 ? 460 LEU A O   1 
ATOM   3364 C  CB  . LEU A 1 460 ? 133.088 155.982 105.229 1.00 56.18 ? 460 LEU A CB  1 
ATOM   3365 C  CG  . LEU A 1 460 ? 133.592 157.025 106.231 1.00 56.18 ? 460 LEU A CG  1 
ATOM   3366 C  CD1 . LEU A 1 460 ? 132.487 157.976 106.614 1.00 56.18 ? 460 LEU A CD1 1 
ATOM   3367 C  CD2 . LEU A 1 460 ? 134.132 156.347 107.465 1.00 56.18 ? 460 LEU A CD2 1 
ATOM   3368 N  N   . PHE A 1 461 ? 133.033 152.925 104.426 1.00 54.77 ? 461 PHE A N   1 
ATOM   3369 C  CA  . PHE A 1 461 ? 132.479 151.708 103.808 1.00 54.77 ? 461 PHE A CA  1 
ATOM   3370 C  C   . PHE A 1 461 ? 133.459 151.081 102.825 1.00 54.77 ? 461 PHE A C   1 
ATOM   3371 O  O   . PHE A 1 461 ? 133.079 150.719 101.710 1.00 54.77 ? 461 PHE A O   1 
ATOM   3372 C  CB  . PHE A 1 461 ? 131.143 151.970 103.113 1.00 54.77 ? 461 PHE A CB  1 
ATOM   3373 C  CG  . PHE A 1 461 ? 130.042 152.363 104.032 1.00 54.77 ? 461 PHE A CG  1 
ATOM   3374 C  CD1 . PHE A 1 461 ? 129.294 151.402 104.682 1.00 54.77 ? 461 PHE A CD1 1 
ATOM   3375 C  CD2 . PHE A 1 461 ? 129.749 153.696 104.235 1.00 54.77 ? 461 PHE A CD2 1 
ATOM   3376 C  CE1 . PHE A 1 461 ? 128.275 151.763 105.517 1.00 54.77 ? 461 PHE A CE1 1 
ATOM   3377 C  CE2 . PHE A 1 461 ? 128.734 154.065 105.069 1.00 54.77 ? 461 PHE A CE2 1 
ATOM   3378 C  CZ  . PHE A 1 461 ? 127.992 153.098 105.710 1.00 54.77 ? 461 PHE A CZ  1 
ATOM   3379 N  N   . ALA A 1 462 ? 134.718 150.946 103.251 1.00 57.59 ? 462 ALA A N   1 
ATOM   3380 C  CA  . ALA A 1 462 ? 135.834 150.609 102.375 1.00 57.59 ? 462 ALA A CA  1 
ATOM   3381 C  C   . ALA A 1 462 ? 135.658 149.231 101.744 1.00 57.59 ? 462 ALA A C   1 
ATOM   3382 O  O   . ALA A 1 462 ? 135.354 148.241 102.414 1.00 57.59 ? 462 ALA A O   1 
ATOM   3383 C  CB  . ALA A 1 462 ? 137.152 150.657 103.143 1.00 57.59 ? 462 ALA A CB  1 
ATOM   3384 N  N   . LYS A 1 463 ? 135.831 149.196 100.424 1.00 54.64 ? 463 LYS A N   1 
ATOM   3385 C  CA  . LYS A 1 463 ? 135.509 148.008 99.645  1.00 54.64 ? 463 LYS A CA  1 
ATOM   3386 C  C   . LYS A 1 463 ? 136.470 146.870 99.943  1.00 54.64 ? 463 LYS A C   1 
ATOM   3387 O  O   . LYS A 1 463 ? 136.046 145.778 100.325 1.00 54.64 ? 463 LYS A O   1 
ATOM   3388 C  CB  . LYS A 1 463 ? 135.518 148.341 98.155  1.00 54.64 ? 463 LYS A CB  1 
ATOM   3389 C  CG  . LYS A 1 463 ? 135.104 147.186 97.275  1.00 54.64 ? 463 LYS A CG  1 
ATOM   3390 C  CD  . LYS A 1 463 ? 135.149 147.561 95.812  1.00 54.64 ? 463 LYS A CD  1 
ATOM   3391 C  CE  . LYS A 1 463 ? 134.043 148.535 95.475  1.00 54.64 ? 463 LYS A CE  1 
ATOM   3392 N  NZ  . LYS A 1 463 ? 132.702 147.905 95.595  1.00 54.64 ? 463 LYS A NZ  1 
ATOM   3393 N  N   . CYS A 1 464 ? 137.766 147.100 99.774  1.00 55.50 ? 464 CYS A N   1 
ATOM   3394 C  CA  . CYS A 1 464 ? 138.764 146.071 100.034 1.00 55.50 ? 464 CYS A CA  1 
ATOM   3395 C  C   . CYS A 1 464 ? 139.939 146.763 100.706 1.00 55.50 ? 464 CYS A C   1 
ATOM   3396 O  O   . CYS A 1 464 ? 140.729 147.439 100.041 1.00 55.50 ? 464 CYS A O   1 
ATOM   3397 C  CB  . CYS A 1 464 ? 139.182 145.371 98.741  1.00 55.50 ? 464 CYS A CB  1 
ATOM   3398 S  SG  . CYS A 1 464 ? 139.846 143.691 98.906  1.00 55.50 ? 464 CYS A SG  1 
ATOM   3399 N  N   . TYR A 1 465 ? 140.037 146.611 102.019 1.00 53.22 ? 465 TYR A N   1 
ATOM   3400 C  CA  . TYR A 1 465 ? 141.025 147.313 102.824 1.00 53.22 ? 465 TYR A CA  1 
ATOM   3401 C  C   . TYR A 1 465 ? 142.350 146.572 102.745 1.00 53.22 ? 465 TYR A C   1 
ATOM   3402 O  O   . TYR A 1 465 ? 142.413 145.394 103.110 1.00 53.22 ? 465 TYR A O   1 
ATOM   3403 C  CB  . TYR A 1 465 ? 140.551 147.399 104.272 1.00 53.22 ? 465 TYR A CB  1 
ATOM   3404 C  CG  . TYR A 1 465 ? 141.458 148.173 105.187 1.00 53.22 ? 465 TYR A CG  1 
ATOM   3405 C  CD1 . TYR A 1 465 ? 141.442 149.553 105.195 1.00 53.22 ? 465 TYR A CD1 1 
ATOM   3406 C  CD2 . TYR A 1 465 ? 142.324 147.523 106.047 1.00 53.22 ? 465 TYR A CD2 1 
ATOM   3407 C  CE1 . TYR A 1 465 ? 142.266 150.264 106.026 1.00 53.22 ? 465 TYR A CE1 1 
ATOM   3408 C  CE2 . TYR A 1 465 ? 143.151 148.229 106.880 1.00 53.22 ? 465 TYR A CE2 1 
ATOM   3409 C  CZ  . TYR A 1 465 ? 143.114 149.597 106.866 1.00 53.22 ? 465 TYR A CZ  1 
ATOM   3410 O  OH  . TYR A 1 465 ? 143.940 150.305 107.700 1.00 53.22 ? 465 TYR A OH  1 
ATOM   3411 N  N   . GLN A 1 466 ? 143.394 147.264 102.276 1.00 55.10 ? 466 GLN A N   1 
ATOM   3412 C  CA  . GLN A 1 466 ? 144.766 146.749 102.155 1.00 55.10 ? 466 GLN A CA  1 
ATOM   3413 C  C   . GLN A 1 466 ? 144.833 145.457 101.337 1.00 55.10 ? 466 GLN A C   1 
ATOM   3414 O  O   . GLN A 1 466 ? 145.378 144.439 101.760 1.00 55.10 ? 466 GLN A O   1 
ATOM   3415 C  CB  . GLN A 1 466 ? 145.406 146.553 103.529 1.00 55.10 ? 466 GLN A CB  1 
ATOM   3416 C  CG  . GLN A 1 466 ? 145.814 147.828 104.224 1.00 55.10 ? 466 GLN A CG  1 
ATOM   3417 C  CD  . GLN A 1 466 ? 146.398 147.558 105.585 1.00 55.10 ? 466 GLN A CD  1 
ATOM   3418 O  OE1 . GLN A 1 466 ? 146.364 146.430 106.067 1.00 55.10 ? 466 GLN A OE1 1 
ATOM   3419 N  NE2 . GLN A 1 466 ? 146.972 148.580 106.200 1.00 55.10 ? 466 GLN A NE2 1 
ATOM   3420 N  N   . CYS A 1 467 ? 144.272 145.522 100.142 1.00 64.88 ? 467 CYS A N   1 
ATOM   3421 C  CA  . CYS A 1 467 ? 144.242 144.400 99.223  1.00 64.88 ? 467 CYS A CA  1 
ATOM   3422 C  C   . CYS A 1 467 ? 145.240 144.650 98.104  1.00 64.88 ? 467 CYS A C   1 
ATOM   3423 O  O   . CYS A 1 467 ? 145.923 145.675 98.074  1.00 64.88 ? 467 CYS A O   1 
ATOM   3424 C  CB  . CYS A 1 467 ? 142.833 144.203 98.658  1.00 64.88 ? 467 CYS A CB  1 
ATOM   3425 S  SG  . CYS A 1 467 ? 141.591 143.839 99.921  1.00 64.88 ? 467 CYS A SG  1 
ATOM   3426 N  N   . LYS A 1 468 ? 145.327 143.696 97.188  1.00 77.06 ? 468 LYS A N   1 
ATOM   3427 C  CA  . LYS A 1 468 ? 146.264 143.798 96.077  1.00 77.06 ? 468 LYS A CA  1 
ATOM   3428 C  C   . LYS A 1 468 ? 145.796 144.868 95.088  1.00 77.06 ? 468 LYS A C   1 
ATOM   3429 O  O   . LYS A 1 468 ? 144.610 145.211 95.062  1.00 77.06 ? 468 LYS A O   1 
ATOM   3430 C  CB  . LYS A 1 468 ? 146.400 142.448 95.368  1.00 77.06 ? 468 LYS A CB  1 
ATOM   3431 C  CG  . LYS A 1 468 ? 145.172 142.008 94.594  1.00 77.06 ? 468 LYS A CG  1 
ATOM   3432 C  CD  . LYS A 1 468 ? 145.392 140.647 93.959  1.00 77.06 ? 468 LYS A CD  1 
ATOM   3433 C  CE  . LYS A 1 468 ? 146.386 140.729 92.809  1.00 77.06 ? 468 LYS A CE  1 
ATOM   3434 N  NZ  . LYS A 1 468 ? 146.549 139.417 92.123  1.00 77.06 ? 468 LYS A NZ  1 
ATOM   3435 N  N   . PRO A 1 469 ? 146.713 145.454 94.296  1.00 82.55 ? 469 PRO A N   1 
ATOM   3436 C  CA  . PRO A 1 469 ? 146.297 146.407 93.259  1.00 82.55 ? 469 PRO A CA  1 
ATOM   3437 C  C   . PRO A 1 469 ? 145.511 145.752 92.126  1.00 82.55 ? 469 PRO A C   1 
ATOM   3438 O  O   . PRO A 1 469 ? 144.748 146.438 91.448  1.00 82.55 ? 469 PRO A O   1 
ATOM   3439 C  CB  . PRO A 1 469 ? 147.627 146.959 92.736  1.00 82.55 ? 469 PRO A CB  1 
ATOM   3440 C  CG  . PRO A 1 469 ? 148.589 146.745 93.849  1.00 82.55 ? 469 PRO A CG  1 
ATOM   3441 C  CD  . PRO A 1 469 ? 148.175 145.459 94.483  1.00 82.55 ? 469 PRO A CD  1 
HETATM 3442 O  O2  . 3C4 B 2 .   ? 143.664 139.619 122.013 1.00 57.20 ? 501 3C4 A O2  1 
HETATM 3443 C  C   . 3C4 B 2 .   ? 142.443 139.869 122.160 1.00 57.20 ? 501 3C4 A C   1 
HETATM 3444 O  O1  . 3C4 B 2 .   ? 141.635 139.727 121.208 1.00 57.20 ? 501 3C4 A O1  1 
HETATM 3445 C  CG  . 3C4 B 2 .   ? 141.916 140.344 123.501 1.00 57.20 ? 501 3C4 A CG  1 
HETATM 3446 C  CA  . 3C4 B 2 .   ? 140.702 139.511 123.869 1.00 57.20 ? 501 3C4 A CA  1 
HETATM 3447 C  CD2 . 3C4 B 2 .   ? 140.839 138.139 123.927 1.00 57.20 ? 501 3C4 A CD2 1 
HETATM 3448 C  CE2 . 3C4 B 2 .   ? 139.758 137.349 124.256 1.00 57.20 ? 501 3C4 A CE2 1 
HETATM 3449 C  CZ  . 3C4 B 2 .   ? 138.542 137.945 124.518 1.00 57.20 ? 501 3C4 A CZ  1 
HETATM 3450 O  OH  . 3C4 B 2 .   ? 137.443 137.152 124.853 1.00 57.20 ? 501 3C4 A OH  1 
HETATM 3451 CL CL  . 3C4 B 2 .   ? 136.811 140.040 124.803 1.00 57.20 ? 501 3C4 A CL  1 
HETATM 3452 C  CE1 . 3C4 B 2 .   ? 138.401 139.316 124.456 1.00 57.20 ? 501 3C4 A CE1 1 
HETATM 3453 C  CD1 . 3C4 B 2 .   ? 139.485 140.110 124.128 1.00 57.20 ? 501 3C4 A CD1 1 
# 
