data_9M12
# 
_entry.id   9M12 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9M12         pdb_00009m12 10.2210/pdb9m12/pdb 
WWPDB D_1300056745 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-11 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9M12 
_pdbx_database_status.recvd_initial_deposition_date   2025-02-25 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              ito.str@tmd.ac.jp 
_pdbx_contact_author.name_first         Nobutoshi 
_pdbx_contact_author.name_last          Ito 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-0839-0384 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Thilakarathne, N.M.H.N.' 1 ? 
'Hanazono, Y.'            2 ? 
'Ito, N.'                 3 ? 
'Kagechika, H.'           4 ? 
'Fujii, S.'               5 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Bioorg.Med.Chem. 
_citation.journal_id_ASTM           BMECEP 
_citation.journal_id_CSD            1200 
_citation.journal_id_ISSN           1464-3391 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                118261 
_citation.page_last                 ? 
_citation.title                     
;Structure-activity relationship and crystallographic analyses of non-secosteroidal vitamin D receptor ligands bearing diphenylsilane core as a hydrophobic pharmacophore
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.bmc.2025.118261 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Mudiyanselage, H.N.T.N.' 1 ? 
primary 'Misawa, T.'              2 ? 
primary 'Ochiai, K.'              3 ? 
primary 'Demizu, Y.'              4 ? 
primary 'Hanazono, Y.'            5 ? 
primary 'Ito, N.'                 6 ? 
primary 'Fujii, S.'               7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Vitamin D3 receptor' 30595.037 2   ? ? ? ? 
2 polymer     syn 'Mediator of RNA polymerase II transcription subunit 1' 1570.898  2   ? ? ? ? 
3 non-polymer nat 
'(4~{S})-5-[2-ethyl-4-[[3-ethyl-4-(2-ethyl-2-oxidanyl-butoxy)phenyl]-dimethyl-silyl]phenoxy]-4-oxidanyl-pentanoic acid' 516.742   
2   ? ? ? ? 
4 water       nat water 18.015    298 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'VDR,1,25-dihydroxyvitamin D3 receptor,Nuclear receptor subfamily 1 group I member 1' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;GSHMGSPNSPLKDSLRPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMDGSTGSVTLDLSPLSMLPHLADLVSY
SIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSWDCGSQDYKYDVTDVSKAGHTLELIEPLIKF
QVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQKLADLRSLNEE
HSKQYRSLSFQPENSMKLTPLVLEVFGNEIS
;
;GSHMGSPNSPLKDSLRPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMDGSTGSVTLDLSPLSMLPHLADLVSY
SIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSWDCGSQDYKYDVTDVSKAGHTLELIEPLIKF
QVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQKLADLRSLNEE
HSKQYRSLSFQPENSMKLTPLVLEVFGNEIS
;
A,B ? 
2 'polypeptide(L)' no no KNHPMLMNLLKDN KNHPMLMNLLKDN C,D ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 '(4~{S})-5-[2-ethyl-4-[[3-ethyl-4-(2-ethyl-2-oxidanyl-butoxy)phenyl]-dimethyl-silyl]phenoxy]-4-oxidanyl-pentanoic acid' A1L7Z 
4 water                                                                                                                   HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   SER n 
1 3   HIS n 
1 4   MET n 
1 5   GLY n 
1 6   SER n 
1 7   PRO n 
1 8   ASN n 
1 9   SER n 
1 10  PRO n 
1 11  LEU n 
1 12  LYS n 
1 13  ASP n 
1 14  SER n 
1 15  LEU n 
1 16  ARG n 
1 17  PRO n 
1 18  LYS n 
1 19  LEU n 
1 20  SER n 
1 21  GLU n 
1 22  GLU n 
1 23  GLN n 
1 24  GLN n 
1 25  HIS n 
1 26  ILE n 
1 27  ILE n 
1 28  ALA n 
1 29  ILE n 
1 30  LEU n 
1 31  LEU n 
1 32  ASP n 
1 33  ALA n 
1 34  HIS n 
1 35  HIS n 
1 36  LYS n 
1 37  THR n 
1 38  TYR n 
1 39  ASP n 
1 40  PRO n 
1 41  THR n 
1 42  TYR n 
1 43  ALA n 
1 44  ASP n 
1 45  PHE n 
1 46  ARG n 
1 47  ASP n 
1 48  PHE n 
1 49  ARG n 
1 50  PRO n 
1 51  PRO n 
1 52  VAL n 
1 53  ARG n 
1 54  MET n 
1 55  ASP n 
1 56  GLY n 
1 57  SER n 
1 58  THR n 
1 59  GLY n 
1 60  SER n 
1 61  VAL n 
1 62  THR n 
1 63  LEU n 
1 64  ASP n 
1 65  LEU n 
1 66  SER n 
1 67  PRO n 
1 68  LEU n 
1 69  SER n 
1 70  MET n 
1 71  LEU n 
1 72  PRO n 
1 73  HIS n 
1 74  LEU n 
1 75  ALA n 
1 76  ASP n 
1 77  LEU n 
1 78  VAL n 
1 79  SER n 
1 80  TYR n 
1 81  SER n 
1 82  ILE n 
1 83  GLN n 
1 84  LYS n 
1 85  VAL n 
1 86  ILE n 
1 87  GLY n 
1 88  PHE n 
1 89  ALA n 
1 90  LYS n 
1 91  MET n 
1 92  ILE n 
1 93  PRO n 
1 94  GLY n 
1 95  PHE n 
1 96  ARG n 
1 97  ASP n 
1 98  LEU n 
1 99  THR n 
1 100 SER n 
1 101 ASP n 
1 102 ASP n 
1 103 GLN n 
1 104 ILE n 
1 105 VAL n 
1 106 LEU n 
1 107 LEU n 
1 108 LYS n 
1 109 SER n 
1 110 SER n 
1 111 ALA n 
1 112 ILE n 
1 113 GLU n 
1 114 VAL n 
1 115 ILE n 
1 116 MET n 
1 117 LEU n 
1 118 ARG n 
1 119 SER n 
1 120 ASN n 
1 121 GLN n 
1 122 SER n 
1 123 PHE n 
1 124 THR n 
1 125 MET n 
1 126 ASP n 
1 127 ASP n 
1 128 MET n 
1 129 SER n 
1 130 TRP n 
1 131 ASP n 
1 132 CYS n 
1 133 GLY n 
1 134 SER n 
1 135 GLN n 
1 136 ASP n 
1 137 TYR n 
1 138 LYS n 
1 139 TYR n 
1 140 ASP n 
1 141 VAL n 
1 142 THR n 
1 143 ASP n 
1 144 VAL n 
1 145 SER n 
1 146 LYS n 
1 147 ALA n 
1 148 GLY n 
1 149 HIS n 
1 150 THR n 
1 151 LEU n 
1 152 GLU n 
1 153 LEU n 
1 154 ILE n 
1 155 GLU n 
1 156 PRO n 
1 157 LEU n 
1 158 ILE n 
1 159 LYS n 
1 160 PHE n 
1 161 GLN n 
1 162 VAL n 
1 163 GLY n 
1 164 LEU n 
1 165 LYS n 
1 166 LYS n 
1 167 LEU n 
1 168 ASN n 
1 169 LEU n 
1 170 HIS n 
1 171 GLU n 
1 172 GLU n 
1 173 GLU n 
1 174 HIS n 
1 175 VAL n 
1 176 LEU n 
1 177 LEU n 
1 178 MET n 
1 179 ALA n 
1 180 ILE n 
1 181 CYS n 
1 182 ILE n 
1 183 VAL n 
1 184 SER n 
1 185 PRO n 
1 186 ASP n 
1 187 ARG n 
1 188 PRO n 
1 189 GLY n 
1 190 VAL n 
1 191 GLN n 
1 192 ASP n 
1 193 ALA n 
1 194 LYS n 
1 195 LEU n 
1 196 VAL n 
1 197 GLU n 
1 198 ALA n 
1 199 ILE n 
1 200 GLN n 
1 201 ASP n 
1 202 ARG n 
1 203 LEU n 
1 204 SER n 
1 205 ASN n 
1 206 THR n 
1 207 LEU n 
1 208 GLN n 
1 209 THR n 
1 210 TYR n 
1 211 ILE n 
1 212 ARG n 
1 213 CYS n 
1 214 ARG n 
1 215 HIS n 
1 216 PRO n 
1 217 PRO n 
1 218 PRO n 
1 219 GLY n 
1 220 SER n 
1 221 HIS n 
1 222 GLN n 
1 223 LEU n 
1 224 TYR n 
1 225 ALA n 
1 226 LYS n 
1 227 MET n 
1 228 ILE n 
1 229 GLN n 
1 230 LYS n 
1 231 LEU n 
1 232 ALA n 
1 233 ASP n 
1 234 LEU n 
1 235 ARG n 
1 236 SER n 
1 237 LEU n 
1 238 ASN n 
1 239 GLU n 
1 240 GLU n 
1 241 HIS n 
1 242 SER n 
1 243 LYS n 
1 244 GLN n 
1 245 TYR n 
1 246 ARG n 
1 247 SER n 
1 248 LEU n 
1 249 SER n 
1 250 PHE n 
1 251 GLN n 
1 252 PRO n 
1 253 GLU n 
1 254 ASN n 
1 255 SER n 
1 256 MET n 
1 257 LYS n 
1 258 LEU n 
1 259 THR n 
1 260 PRO n 
1 261 LEU n 
1 262 VAL n 
1 263 LEU n 
1 264 GLU n 
1 265 VAL n 
1 266 PHE n 
1 267 GLY n 
1 268 ASN n 
1 269 GLU n 
1 270 ILE n 
1 271 SER n 
2 1   LYS n 
2 2   ASN n 
2 3   HIS n 
2 4   PRO n 
2 5   MET n 
2 6   LEU n 
2 7   MET n 
2 8   ASN n 
2 9   LEU n 
2 10  LEU n 
2 11  LYS n 
2 12  ASP n 
2 13  ASN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   271 
_entity_src_gen.gene_src_common_name               'Norway rat' 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'Vdr, Nr1i1' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Rattus norvegicus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     10116 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              2 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       13 
_pdbx_entity_src_syn.organism_scientific    'Homo sapiens' 
_pdbx_entity_src_syn.organism_common_name   human 
_pdbx_entity_src_syn.ncbi_taxonomy_id       9606 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1L7Z non-polymer         . 
'(4~{S})-5-[2-ethyl-4-[[3-ethyl-4-(2-ethyl-2-oxidanyl-butoxy)phenyl]-dimethyl-silyl]phenoxy]-4-oxidanyl-pentanoic acid' ? 
'C29 H44 O6 Si'  516.742 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'     89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'    132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'   121.158 
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'   146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'     75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 
HOH   non-polymer         . WATER ? 'H2 O'           18.015  
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'    131.173 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'    131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'  149.211 
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'    165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'     115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'     105.093 
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'     119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'  204.225 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'    181.189 
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   106 ?   ?   ?   A . n 
A 1 2   SER 2   107 ?   ?   ?   A . n 
A 1 3   HIS 3   108 ?   ?   ?   A . n 
A 1 4   MET 4   109 ?   ?   ?   A . n 
A 1 5   GLY 5   110 ?   ?   ?   A . n 
A 1 6   SER 6   111 ?   ?   ?   A . n 
A 1 7   PRO 7   112 ?   ?   ?   A . n 
A 1 8   ASN 8   113 ?   ?   ?   A . n 
A 1 9   SER 9   114 ?   ?   ?   A . n 
A 1 10  PRO 10  115 ?   ?   ?   A . n 
A 1 11  LEU 11  116 ?   ?   ?   A . n 
A 1 12  LYS 12  117 ?   ?   ?   A . n 
A 1 13  ASP 13  118 ?   ?   ?   A . n 
A 1 14  SER 14  119 ?   ?   ?   A . n 
A 1 15  LEU 15  120 ?   ?   ?   A . n 
A 1 16  ARG 16  121 ?   ?   ?   A . n 
A 1 17  PRO 17  122 ?   ?   ?   A . n 
A 1 18  LYS 18  123 123 LYS LYS A . n 
A 1 19  LEU 19  124 124 LEU LEU A . n 
A 1 20  SER 20  125 125 SER SER A . n 
A 1 21  GLU 21  126 126 GLU GLU A . n 
A 1 22  GLU 22  127 127 GLU GLU A . n 
A 1 23  GLN 23  128 128 GLN GLN A . n 
A 1 24  GLN 24  129 129 GLN GLN A . n 
A 1 25  HIS 25  130 130 HIS HIS A . n 
A 1 26  ILE 26  131 131 ILE ILE A . n 
A 1 27  ILE 27  132 132 ILE ILE A . n 
A 1 28  ALA 28  133 133 ALA ALA A . n 
A 1 29  ILE 29  134 134 ILE ILE A . n 
A 1 30  LEU 30  135 135 LEU LEU A . n 
A 1 31  LEU 31  136 136 LEU LEU A . n 
A 1 32  ASP 32  137 137 ASP ASP A . n 
A 1 33  ALA 33  138 138 ALA ALA A . n 
A 1 34  HIS 34  139 139 HIS HIS A . n 
A 1 35  HIS 35  140 140 HIS HIS A . n 
A 1 36  LYS 36  141 141 LYS LYS A . n 
A 1 37  THR 37  142 142 THR THR A . n 
A 1 38  TYR 38  143 143 TYR TYR A . n 
A 1 39  ASP 39  144 144 ASP ASP A . n 
A 1 40  PRO 40  145 145 PRO PRO A . n 
A 1 41  THR 41  146 146 THR THR A . n 
A 1 42  TYR 42  147 147 TYR TYR A . n 
A 1 43  ALA 43  148 148 ALA ALA A . n 
A 1 44  ASP 44  149 149 ASP ASP A . n 
A 1 45  PHE 45  150 150 PHE PHE A . n 
A 1 46  ARG 46  151 151 ARG ARG A . n 
A 1 47  ASP 47  152 152 ASP ASP A . n 
A 1 48  PHE 48  153 153 PHE PHE A . n 
A 1 49  ARG 49  154 154 ARG ARG A . n 
A 1 50  PRO 50  155 155 PRO PRO A . n 
A 1 51  PRO 51  156 156 PRO PRO A . n 
A 1 52  VAL 52  157 157 VAL VAL A . n 
A 1 53  ARG 53  158 158 ARG ARG A . n 
A 1 54  MET 54  159 159 MET MET A . n 
A 1 55  ASP 55  207 ?   ?   ?   A . n 
A 1 56  GLY 56  208 ?   ?   ?   A . n 
A 1 57  SER 57  209 ?   ?   ?   A . n 
A 1 58  THR 58  210 ?   ?   ?   A . n 
A 1 59  GLY 59  211 ?   ?   ?   A . n 
A 1 60  SER 60  212 ?   ?   ?   A . n 
A 1 61  VAL 61  213 ?   ?   ?   A . n 
A 1 62  THR 62  214 ?   ?   ?   A . n 
A 1 63  LEU 63  215 ?   ?   ?   A . n 
A 1 64  ASP 64  216 ?   ?   ?   A . n 
A 1 65  LEU 65  217 ?   ?   ?   A . n 
A 1 66  SER 66  218 218 SER SER A . n 
A 1 67  PRO 67  219 219 PRO PRO A . n 
A 1 68  LEU 68  220 220 LEU LEU A . n 
A 1 69  SER 69  221 221 SER SER A . n 
A 1 70  MET 70  222 222 MET MET A . n 
A 1 71  LEU 71  223 223 LEU LEU A . n 
A 1 72  PRO 72  224 224 PRO PRO A . n 
A 1 73  HIS 73  225 225 HIS HIS A . n 
A 1 74  LEU 74  226 226 LEU LEU A . n 
A 1 75  ALA 75  227 227 ALA ALA A . n 
A 1 76  ASP 76  228 228 ASP ASP A . n 
A 1 77  LEU 77  229 229 LEU LEU A . n 
A 1 78  VAL 78  230 230 VAL VAL A . n 
A 1 79  SER 79  231 231 SER SER A . n 
A 1 80  TYR 80  232 232 TYR TYR A . n 
A 1 81  SER 81  233 233 SER SER A . n 
A 1 82  ILE 82  234 234 ILE ILE A . n 
A 1 83  GLN 83  235 235 GLN GLN A . n 
A 1 84  LYS 84  236 236 LYS LYS A . n 
A 1 85  VAL 85  237 237 VAL VAL A . n 
A 1 86  ILE 86  238 238 ILE ILE A . n 
A 1 87  GLY 87  239 239 GLY GLY A . n 
A 1 88  PHE 88  240 240 PHE PHE A . n 
A 1 89  ALA 89  241 241 ALA ALA A . n 
A 1 90  LYS 90  242 242 LYS LYS A . n 
A 1 91  MET 91  243 243 MET MET A . n 
A 1 92  ILE 92  244 244 ILE ILE A . n 
A 1 93  PRO 93  245 245 PRO PRO A . n 
A 1 94  GLY 94  246 246 GLY GLY A . n 
A 1 95  PHE 95  247 247 PHE PHE A . n 
A 1 96  ARG 96  248 248 ARG ARG A . n 
A 1 97  ASP 97  249 249 ASP ASP A . n 
A 1 98  LEU 98  250 250 LEU LEU A . n 
A 1 99  THR 99  251 251 THR THR A . n 
A 1 100 SER 100 252 252 SER SER A . n 
A 1 101 ASP 101 253 253 ASP ASP A . n 
A 1 102 ASP 102 254 254 ASP ASP A . n 
A 1 103 GLN 103 255 255 GLN GLN A . n 
A 1 104 ILE 104 256 256 ILE ILE A . n 
A 1 105 VAL 105 257 257 VAL VAL A . n 
A 1 106 LEU 106 258 258 LEU LEU A . n 
A 1 107 LEU 107 259 259 LEU LEU A . n 
A 1 108 LYS 108 260 260 LYS LYS A . n 
A 1 109 SER 109 261 261 SER SER A . n 
A 1 110 SER 110 262 262 SER SER A . n 
A 1 111 ALA 111 263 263 ALA ALA A . n 
A 1 112 ILE 112 264 264 ILE ILE A . n 
A 1 113 GLU 113 265 265 GLU GLU A . n 
A 1 114 VAL 114 266 266 VAL VAL A . n 
A 1 115 ILE 115 267 267 ILE ILE A . n 
A 1 116 MET 116 268 268 MET MET A . n 
A 1 117 LEU 117 269 269 LEU LEU A . n 
A 1 118 ARG 118 270 270 ARG ARG A . n 
A 1 119 SER 119 271 271 SER SER A . n 
A 1 120 ASN 120 272 272 ASN ASN A . n 
A 1 121 GLN 121 273 273 GLN GLN A . n 
A 1 122 SER 122 274 274 SER SER A . n 
A 1 123 PHE 123 275 275 PHE PHE A . n 
A 1 124 THR 124 276 276 THR THR A . n 
A 1 125 MET 125 277 277 MET MET A . n 
A 1 126 ASP 126 278 278 ASP ASP A . n 
A 1 127 ASP 127 279 279 ASP ASP A . n 
A 1 128 MET 128 280 280 MET MET A . n 
A 1 129 SER 129 281 281 SER SER A . n 
A 1 130 TRP 130 282 282 TRP TRP A . n 
A 1 131 ASP 131 283 283 ASP ASP A . n 
A 1 132 CYS 132 284 284 CYS CYS A . n 
A 1 133 GLY 133 285 285 GLY GLY A . n 
A 1 134 SER 134 286 286 SER SER A . n 
A 1 135 GLN 135 287 287 GLN GLN A . n 
A 1 136 ASP 136 288 288 ASP ASP A . n 
A 1 137 TYR 137 289 289 TYR TYR A . n 
A 1 138 LYS 138 290 290 LYS LYS A . n 
A 1 139 TYR 139 291 291 TYR TYR A . n 
A 1 140 ASP 140 292 292 ASP ASP A . n 
A 1 141 VAL 141 293 293 VAL VAL A . n 
A 1 142 THR 142 294 294 THR THR A . n 
A 1 143 ASP 143 295 295 ASP ASP A . n 
A 1 144 VAL 144 296 296 VAL VAL A . n 
A 1 145 SER 145 297 297 SER SER A . n 
A 1 146 LYS 146 298 298 LYS LYS A . n 
A 1 147 ALA 147 299 299 ALA ALA A . n 
A 1 148 GLY 148 300 300 GLY GLY A . n 
A 1 149 HIS 149 301 301 HIS HIS A . n 
A 1 150 THR 150 302 302 THR THR A . n 
A 1 151 LEU 151 303 303 LEU LEU A . n 
A 1 152 GLU 152 304 304 GLU GLU A . n 
A 1 153 LEU 153 305 305 LEU LEU A . n 
A 1 154 ILE 154 306 306 ILE ILE A . n 
A 1 155 GLU 155 307 307 GLU GLU A . n 
A 1 156 PRO 156 308 308 PRO PRO A . n 
A 1 157 LEU 157 309 309 LEU LEU A . n 
A 1 158 ILE 158 310 310 ILE ILE A . n 
A 1 159 LYS 159 311 311 LYS LYS A . n 
A 1 160 PHE 160 312 312 PHE PHE A . n 
A 1 161 GLN 161 313 313 GLN GLN A . n 
A 1 162 VAL 162 314 314 VAL VAL A . n 
A 1 163 GLY 163 315 315 GLY GLY A . n 
A 1 164 LEU 164 316 316 LEU LEU A . n 
A 1 165 LYS 165 317 317 LYS LYS A . n 
A 1 166 LYS 166 318 318 LYS LYS A . n 
A 1 167 LEU 167 319 319 LEU LEU A . n 
A 1 168 ASN 168 320 320 ASN ASN A . n 
A 1 169 LEU 169 321 321 LEU LEU A . n 
A 1 170 HIS 170 322 322 HIS HIS A . n 
A 1 171 GLU 171 323 323 GLU GLU A . n 
A 1 172 GLU 172 324 324 GLU GLU A . n 
A 1 173 GLU 173 325 325 GLU GLU A . n 
A 1 174 HIS 174 326 326 HIS HIS A . n 
A 1 175 VAL 175 327 327 VAL VAL A . n 
A 1 176 LEU 176 328 328 LEU LEU A . n 
A 1 177 LEU 177 329 329 LEU LEU A . n 
A 1 178 MET 178 330 330 MET MET A . n 
A 1 179 ALA 179 331 331 ALA ALA A . n 
A 1 180 ILE 180 332 332 ILE ILE A . n 
A 1 181 CYS 181 333 333 CYS CYS A . n 
A 1 182 ILE 182 334 334 ILE ILE A . n 
A 1 183 VAL 183 335 335 VAL VAL A . n 
A 1 184 SER 184 336 336 SER SER A . n 
A 1 185 PRO 185 337 337 PRO PRO A . n 
A 1 186 ASP 186 338 338 ASP ASP A . n 
A 1 187 ARG 187 339 339 ARG ARG A . n 
A 1 188 PRO 188 340 340 PRO PRO A . n 
A 1 189 GLY 189 341 341 GLY GLY A . n 
A 1 190 VAL 190 342 342 VAL VAL A . n 
A 1 191 GLN 191 343 343 GLN GLN A . n 
A 1 192 ASP 192 344 344 ASP ASP A . n 
A 1 193 ALA 193 345 345 ALA ALA A . n 
A 1 194 LYS 194 346 346 LYS LYS A . n 
A 1 195 LEU 195 347 347 LEU LEU A . n 
A 1 196 VAL 196 348 348 VAL VAL A . n 
A 1 197 GLU 197 349 349 GLU GLU A . n 
A 1 198 ALA 198 350 350 ALA ALA A . n 
A 1 199 ILE 199 351 351 ILE ILE A . n 
A 1 200 GLN 200 352 352 GLN GLN A . n 
A 1 201 ASP 201 353 353 ASP ASP A . n 
A 1 202 ARG 202 354 354 ARG ARG A . n 
A 1 203 LEU 203 355 355 LEU LEU A . n 
A 1 204 SER 204 356 356 SER SER A . n 
A 1 205 ASN 205 357 357 ASN ASN A . n 
A 1 206 THR 206 358 358 THR THR A . n 
A 1 207 LEU 207 359 359 LEU LEU A . n 
A 1 208 GLN 208 360 360 GLN GLN A . n 
A 1 209 THR 209 361 361 THR THR A . n 
A 1 210 TYR 210 362 362 TYR TYR A . n 
A 1 211 ILE 211 363 363 ILE ILE A . n 
A 1 212 ARG 212 364 364 ARG ARG A . n 
A 1 213 CYS 213 365 365 CYS CYS A . n 
A 1 214 ARG 214 366 366 ARG ARG A . n 
A 1 215 HIS 215 367 367 HIS HIS A . n 
A 1 216 PRO 216 368 368 PRO PRO A . n 
A 1 217 PRO 217 369 369 PRO PRO A . n 
A 1 218 PRO 218 370 370 PRO PRO A . n 
A 1 219 GLY 219 371 371 GLY GLY A . n 
A 1 220 SER 220 372 372 SER SER A . n 
A 1 221 HIS 221 373 373 HIS HIS A . n 
A 1 222 GLN 222 374 374 GLN GLN A . n 
A 1 223 LEU 223 375 375 LEU LEU A . n 
A 1 224 TYR 224 376 376 TYR TYR A . n 
A 1 225 ALA 225 377 377 ALA ALA A . n 
A 1 226 LYS 226 378 378 LYS LYS A . n 
A 1 227 MET 227 379 379 MET MET A . n 
A 1 228 ILE 228 380 380 ILE ILE A . n 
A 1 229 GLN 229 381 381 GLN GLN A . n 
A 1 230 LYS 230 382 382 LYS LYS A . n 
A 1 231 LEU 231 383 383 LEU LEU A . n 
A 1 232 ALA 232 384 384 ALA ALA A . n 
A 1 233 ASP 233 385 385 ASP ASP A . n 
A 1 234 LEU 234 386 386 LEU LEU A . n 
A 1 235 ARG 235 387 387 ARG ARG A . n 
A 1 236 SER 236 388 388 SER SER A . n 
A 1 237 LEU 237 389 389 LEU LEU A . n 
A 1 238 ASN 238 390 390 ASN ASN A . n 
A 1 239 GLU 239 391 391 GLU GLU A . n 
A 1 240 GLU 240 392 392 GLU GLU A . n 
A 1 241 HIS 241 393 393 HIS HIS A . n 
A 1 242 SER 242 394 394 SER SER A . n 
A 1 243 LYS 243 395 395 LYS LYS A . n 
A 1 244 GLN 244 396 396 GLN GLN A . n 
A 1 245 TYR 245 397 397 TYR TYR A . n 
A 1 246 ARG 246 398 398 ARG ARG A . n 
A 1 247 SER 247 399 399 SER SER A . n 
A 1 248 LEU 248 400 400 LEU LEU A . n 
A 1 249 SER 249 401 401 SER SER A . n 
A 1 250 PHE 250 402 402 PHE PHE A . n 
A 1 251 GLN 251 403 403 GLN GLN A . n 
A 1 252 PRO 252 404 404 PRO PRO A . n 
A 1 253 GLU 253 405 405 GLU GLU A . n 
A 1 254 ASN 254 406 406 ASN ASN A . n 
A 1 255 SER 255 407 407 SER SER A . n 
A 1 256 MET 256 408 408 MET MET A . n 
A 1 257 LYS 257 409 409 LYS LYS A . n 
A 1 258 LEU 258 410 410 LEU LEU A . n 
A 1 259 THR 259 411 411 THR THR A . n 
A 1 260 PRO 260 412 412 PRO PRO A . n 
A 1 261 LEU 261 413 413 LEU LEU A . n 
A 1 262 VAL 262 414 414 VAL VAL A . n 
A 1 263 LEU 263 415 415 LEU LEU A . n 
A 1 264 GLU 264 416 416 GLU GLU A . n 
A 1 265 VAL 265 417 417 VAL VAL A . n 
A 1 266 PHE 266 418 418 PHE PHE A . n 
A 1 267 GLY 267 419 419 GLY GLY A . n 
A 1 268 ASN 268 420 420 ASN ASN A . n 
A 1 269 GLU 269 421 ?   ?   ?   A . n 
A 1 270 ILE 270 422 ?   ?   ?   A . n 
A 1 271 SER 271 423 ?   ?   ?   A . n 
B 2 1   LYS 1   625 625 LYS LYS C . n 
B 2 2   ASN 2   626 626 ASN ASN C . n 
B 2 3   HIS 3   627 627 HIS HIS C . n 
B 2 4   PRO 4   628 628 PRO PRO C . n 
B 2 5   MET 5   629 629 MET MET C . n 
B 2 6   LEU 6   630 630 LEU LEU C . n 
B 2 7   MET 7   631 631 MET MET C . n 
B 2 8   ASN 8   632 632 ASN ASN C . n 
B 2 9   LEU 9   633 633 LEU LEU C . n 
B 2 10  LEU 10  634 634 LEU LEU C . n 
B 2 11  LYS 11  635 635 LYS LYS C . n 
B 2 12  ASP 12  636 ?   ?   ?   C . n 
B 2 13  ASN 13  637 ?   ?   ?   C . n 
C 1 1   GLY 1   106 ?   ?   ?   B . n 
C 1 2   SER 2   107 ?   ?   ?   B . n 
C 1 3   HIS 3   108 ?   ?   ?   B . n 
C 1 4   MET 4   109 ?   ?   ?   B . n 
C 1 5   GLY 5   110 ?   ?   ?   B . n 
C 1 6   SER 6   111 ?   ?   ?   B . n 
C 1 7   PRO 7   112 ?   ?   ?   B . n 
C 1 8   ASN 8   113 ?   ?   ?   B . n 
C 1 9   SER 9   114 ?   ?   ?   B . n 
C 1 10  PRO 10  115 ?   ?   ?   B . n 
C 1 11  LEU 11  116 ?   ?   ?   B . n 
C 1 12  LYS 12  117 ?   ?   ?   B . n 
C 1 13  ASP 13  118 ?   ?   ?   B . n 
C 1 14  SER 14  119 ?   ?   ?   B . n 
C 1 15  LEU 15  120 ?   ?   ?   B . n 
C 1 16  ARG 16  121 ?   ?   ?   B . n 
C 1 17  PRO 17  122 ?   ?   ?   B . n 
C 1 18  LYS 18  123 123 LYS LYS B . n 
C 1 19  LEU 19  124 124 LEU LEU B . n 
C 1 20  SER 20  125 125 SER SER B . n 
C 1 21  GLU 21  126 126 GLU GLU B . n 
C 1 22  GLU 22  127 127 GLU GLU B . n 
C 1 23  GLN 23  128 128 GLN GLN B . n 
C 1 24  GLN 24  129 129 GLN GLN B . n 
C 1 25  HIS 25  130 130 HIS HIS B . n 
C 1 26  ILE 26  131 131 ILE ILE B . n 
C 1 27  ILE 27  132 132 ILE ILE B . n 
C 1 28  ALA 28  133 133 ALA ALA B . n 
C 1 29  ILE 29  134 134 ILE ILE B . n 
C 1 30  LEU 30  135 135 LEU LEU B . n 
C 1 31  LEU 31  136 136 LEU LEU B . n 
C 1 32  ASP 32  137 137 ASP ASP B . n 
C 1 33  ALA 33  138 138 ALA ALA B . n 
C 1 34  HIS 34  139 139 HIS HIS B . n 
C 1 35  HIS 35  140 140 HIS HIS B . n 
C 1 36  LYS 36  141 141 LYS LYS B . n 
C 1 37  THR 37  142 142 THR THR B . n 
C 1 38  TYR 38  143 143 TYR TYR B . n 
C 1 39  ASP 39  144 144 ASP ASP B . n 
C 1 40  PRO 40  145 145 PRO PRO B . n 
C 1 41  THR 41  146 146 THR THR B . n 
C 1 42  TYR 42  147 147 TYR TYR B . n 
C 1 43  ALA 43  148 148 ALA ALA B . n 
C 1 44  ASP 44  149 149 ASP ASP B . n 
C 1 45  PHE 45  150 150 PHE PHE B . n 
C 1 46  ARG 46  151 151 ARG ARG B . n 
C 1 47  ASP 47  152 152 ASP ASP B . n 
C 1 48  PHE 48  153 153 PHE PHE B . n 
C 1 49  ARG 49  154 154 ARG ARG B . n 
C 1 50  PRO 50  155 155 PRO PRO B . n 
C 1 51  PRO 51  156 156 PRO PRO B . n 
C 1 52  VAL 52  157 157 VAL VAL B . n 
C 1 53  ARG 53  158 158 ARG ARG B . n 
C 1 54  MET 54  159 159 MET MET B . n 
C 1 55  ASP 55  207 ?   ?   ?   B . n 
C 1 56  GLY 56  208 ?   ?   ?   B . n 
C 1 57  SER 57  209 ?   ?   ?   B . n 
C 1 58  THR 58  210 ?   ?   ?   B . n 
C 1 59  GLY 59  211 ?   ?   ?   B . n 
C 1 60  SER 60  212 ?   ?   ?   B . n 
C 1 61  VAL 61  213 ?   ?   ?   B . n 
C 1 62  THR 62  214 ?   ?   ?   B . n 
C 1 63  LEU 63  215 ?   ?   ?   B . n 
C 1 64  ASP 64  216 ?   ?   ?   B . n 
C 1 65  LEU 65  217 ?   ?   ?   B . n 
C 1 66  SER 66  218 218 SER SER B . n 
C 1 67  PRO 67  219 219 PRO PRO B . n 
C 1 68  LEU 68  220 220 LEU LEU B . n 
C 1 69  SER 69  221 221 SER SER B . n 
C 1 70  MET 70  222 222 MET MET B . n 
C 1 71  LEU 71  223 223 LEU LEU B . n 
C 1 72  PRO 72  224 224 PRO PRO B . n 
C 1 73  HIS 73  225 225 HIS HIS B . n 
C 1 74  LEU 74  226 226 LEU LEU B . n 
C 1 75  ALA 75  227 227 ALA ALA B . n 
C 1 76  ASP 76  228 228 ASP ASP B . n 
C 1 77  LEU 77  229 229 LEU LEU B . n 
C 1 78  VAL 78  230 230 VAL VAL B . n 
C 1 79  SER 79  231 231 SER SER B . n 
C 1 80  TYR 80  232 232 TYR TYR B . n 
C 1 81  SER 81  233 233 SER SER B . n 
C 1 82  ILE 82  234 234 ILE ILE B . n 
C 1 83  GLN 83  235 235 GLN GLN B . n 
C 1 84  LYS 84  236 236 LYS LYS B . n 
C 1 85  VAL 85  237 237 VAL VAL B . n 
C 1 86  ILE 86  238 238 ILE ILE B . n 
C 1 87  GLY 87  239 239 GLY GLY B . n 
C 1 88  PHE 88  240 240 PHE PHE B . n 
C 1 89  ALA 89  241 241 ALA ALA B . n 
C 1 90  LYS 90  242 242 LYS LYS B . n 
C 1 91  MET 91  243 243 MET MET B . n 
C 1 92  ILE 92  244 244 ILE ILE B . n 
C 1 93  PRO 93  245 245 PRO PRO B . n 
C 1 94  GLY 94  246 246 GLY GLY B . n 
C 1 95  PHE 95  247 247 PHE PHE B . n 
C 1 96  ARG 96  248 248 ARG ARG B . n 
C 1 97  ASP 97  249 249 ASP ASP B . n 
C 1 98  LEU 98  250 250 LEU LEU B . n 
C 1 99  THR 99  251 251 THR THR B . n 
C 1 100 SER 100 252 252 SER SER B . n 
C 1 101 ASP 101 253 253 ASP ASP B . n 
C 1 102 ASP 102 254 254 ASP ASP B . n 
C 1 103 GLN 103 255 255 GLN GLN B . n 
C 1 104 ILE 104 256 256 ILE ILE B . n 
C 1 105 VAL 105 257 257 VAL VAL B . n 
C 1 106 LEU 106 258 258 LEU LEU B . n 
C 1 107 LEU 107 259 259 LEU LEU B . n 
C 1 108 LYS 108 260 260 LYS LYS B . n 
C 1 109 SER 109 261 261 SER SER B . n 
C 1 110 SER 110 262 262 SER SER B . n 
C 1 111 ALA 111 263 263 ALA ALA B . n 
C 1 112 ILE 112 264 264 ILE ILE B . n 
C 1 113 GLU 113 265 265 GLU GLU B . n 
C 1 114 VAL 114 266 266 VAL VAL B . n 
C 1 115 ILE 115 267 267 ILE ILE B . n 
C 1 116 MET 116 268 268 MET MET B . n 
C 1 117 LEU 117 269 269 LEU LEU B . n 
C 1 118 ARG 118 270 270 ARG ARG B . n 
C 1 119 SER 119 271 271 SER SER B . n 
C 1 120 ASN 120 272 272 ASN ASN B . n 
C 1 121 GLN 121 273 273 GLN GLN B . n 
C 1 122 SER 122 274 274 SER SER B . n 
C 1 123 PHE 123 275 275 PHE PHE B . n 
C 1 124 THR 124 276 276 THR THR B . n 
C 1 125 MET 125 277 277 MET MET B . n 
C 1 126 ASP 126 278 278 ASP ASP B . n 
C 1 127 ASP 127 279 279 ASP ASP B . n 
C 1 128 MET 128 280 280 MET MET B . n 
C 1 129 SER 129 281 281 SER SER B . n 
C 1 130 TRP 130 282 282 TRP TRP B . n 
C 1 131 ASP 131 283 283 ASP ASP B . n 
C 1 132 CYS 132 284 284 CYS CYS B . n 
C 1 133 GLY 133 285 285 GLY GLY B . n 
C 1 134 SER 134 286 286 SER SER B . n 
C 1 135 GLN 135 287 287 GLN GLN B . n 
C 1 136 ASP 136 288 288 ASP ASP B . n 
C 1 137 TYR 137 289 289 TYR TYR B . n 
C 1 138 LYS 138 290 290 LYS LYS B . n 
C 1 139 TYR 139 291 291 TYR TYR B . n 
C 1 140 ASP 140 292 292 ASP ASP B . n 
C 1 141 VAL 141 293 293 VAL VAL B . n 
C 1 142 THR 142 294 294 THR THR B . n 
C 1 143 ASP 143 295 295 ASP ASP B . n 
C 1 144 VAL 144 296 296 VAL VAL B . n 
C 1 145 SER 145 297 297 SER SER B . n 
C 1 146 LYS 146 298 298 LYS LYS B . n 
C 1 147 ALA 147 299 299 ALA ALA B . n 
C 1 148 GLY 148 300 300 GLY GLY B . n 
C 1 149 HIS 149 301 301 HIS HIS B . n 
C 1 150 THR 150 302 302 THR THR B . n 
C 1 151 LEU 151 303 303 LEU LEU B . n 
C 1 152 GLU 152 304 304 GLU GLU B . n 
C 1 153 LEU 153 305 305 LEU LEU B . n 
C 1 154 ILE 154 306 306 ILE ILE B . n 
C 1 155 GLU 155 307 307 GLU GLU B . n 
C 1 156 PRO 156 308 308 PRO PRO B . n 
C 1 157 LEU 157 309 309 LEU LEU B . n 
C 1 158 ILE 158 310 310 ILE ILE B . n 
C 1 159 LYS 159 311 311 LYS LYS B . n 
C 1 160 PHE 160 312 312 PHE PHE B . n 
C 1 161 GLN 161 313 313 GLN GLN B . n 
C 1 162 VAL 162 314 314 VAL VAL B . n 
C 1 163 GLY 163 315 315 GLY GLY B . n 
C 1 164 LEU 164 316 316 LEU LEU B . n 
C 1 165 LYS 165 317 317 LYS LYS B . n 
C 1 166 LYS 166 318 318 LYS LYS B . n 
C 1 167 LEU 167 319 319 LEU LEU B . n 
C 1 168 ASN 168 320 320 ASN ASN B . n 
C 1 169 LEU 169 321 321 LEU LEU B . n 
C 1 170 HIS 170 322 322 HIS HIS B . n 
C 1 171 GLU 171 323 323 GLU GLU B . n 
C 1 172 GLU 172 324 324 GLU GLU B . n 
C 1 173 GLU 173 325 325 GLU GLU B . n 
C 1 174 HIS 174 326 326 HIS HIS B . n 
C 1 175 VAL 175 327 327 VAL VAL B . n 
C 1 176 LEU 176 328 328 LEU LEU B . n 
C 1 177 LEU 177 329 329 LEU LEU B . n 
C 1 178 MET 178 330 330 MET MET B . n 
C 1 179 ALA 179 331 331 ALA ALA B . n 
C 1 180 ILE 180 332 332 ILE ILE B . n 
C 1 181 CYS 181 333 333 CYS CYS B . n 
C 1 182 ILE 182 334 334 ILE ILE B . n 
C 1 183 VAL 183 335 335 VAL VAL B . n 
C 1 184 SER 184 336 336 SER SER B . n 
C 1 185 PRO 185 337 337 PRO PRO B . n 
C 1 186 ASP 186 338 338 ASP ASP B . n 
C 1 187 ARG 187 339 339 ARG ARG B . n 
C 1 188 PRO 188 340 340 PRO PRO B . n 
C 1 189 GLY 189 341 341 GLY GLY B . n 
C 1 190 VAL 190 342 342 VAL VAL B . n 
C 1 191 GLN 191 343 343 GLN GLN B . n 
C 1 192 ASP 192 344 344 ASP ASP B . n 
C 1 193 ALA 193 345 345 ALA ALA B . n 
C 1 194 LYS 194 346 346 LYS LYS B . n 
C 1 195 LEU 195 347 347 LEU LEU B . n 
C 1 196 VAL 196 348 348 VAL VAL B . n 
C 1 197 GLU 197 349 349 GLU GLU B . n 
C 1 198 ALA 198 350 350 ALA ALA B . n 
C 1 199 ILE 199 351 351 ILE ILE B . n 
C 1 200 GLN 200 352 352 GLN GLN B . n 
C 1 201 ASP 201 353 353 ASP ASP B . n 
C 1 202 ARG 202 354 354 ARG ARG B . n 
C 1 203 LEU 203 355 355 LEU LEU B . n 
C 1 204 SER 204 356 356 SER SER B . n 
C 1 205 ASN 205 357 357 ASN ASN B . n 
C 1 206 THR 206 358 358 THR THR B . n 
C 1 207 LEU 207 359 359 LEU LEU B . n 
C 1 208 GLN 208 360 360 GLN GLN B . n 
C 1 209 THR 209 361 361 THR THR B . n 
C 1 210 TYR 210 362 362 TYR TYR B . n 
C 1 211 ILE 211 363 363 ILE ILE B . n 
C 1 212 ARG 212 364 364 ARG ARG B . n 
C 1 213 CYS 213 365 365 CYS CYS B . n 
C 1 214 ARG 214 366 366 ARG ARG B . n 
C 1 215 HIS 215 367 367 HIS HIS B . n 
C 1 216 PRO 216 368 368 PRO PRO B . n 
C 1 217 PRO 217 369 369 PRO PRO B . n 
C 1 218 PRO 218 370 370 PRO PRO B . n 
C 1 219 GLY 219 371 371 GLY GLY B . n 
C 1 220 SER 220 372 372 SER SER B . n 
C 1 221 HIS 221 373 373 HIS HIS B . n 
C 1 222 GLN 222 374 374 GLN GLN B . n 
C 1 223 LEU 223 375 375 LEU LEU B . n 
C 1 224 TYR 224 376 376 TYR TYR B . n 
C 1 225 ALA 225 377 377 ALA ALA B . n 
C 1 226 LYS 226 378 378 LYS LYS B . n 
C 1 227 MET 227 379 379 MET MET B . n 
C 1 228 ILE 228 380 380 ILE ILE B . n 
C 1 229 GLN 229 381 381 GLN GLN B . n 
C 1 230 LYS 230 382 382 LYS LYS B . n 
C 1 231 LEU 231 383 383 LEU LEU B . n 
C 1 232 ALA 232 384 384 ALA ALA B . n 
C 1 233 ASP 233 385 385 ASP ASP B . n 
C 1 234 LEU 234 386 386 LEU LEU B . n 
C 1 235 ARG 235 387 387 ARG ARG B . n 
C 1 236 SER 236 388 388 SER SER B . n 
C 1 237 LEU 237 389 389 LEU LEU B . n 
C 1 238 ASN 238 390 390 ASN ASN B . n 
C 1 239 GLU 239 391 391 GLU GLU B . n 
C 1 240 GLU 240 392 392 GLU GLU B . n 
C 1 241 HIS 241 393 393 HIS HIS B . n 
C 1 242 SER 242 394 394 SER SER B . n 
C 1 243 LYS 243 395 395 LYS LYS B . n 
C 1 244 GLN 244 396 396 GLN GLN B . n 
C 1 245 TYR 245 397 397 TYR TYR B . n 
C 1 246 ARG 246 398 398 ARG ARG B . n 
C 1 247 SER 247 399 399 SER SER B . n 
C 1 248 LEU 248 400 400 LEU LEU B . n 
C 1 249 SER 249 401 401 SER SER B . n 
C 1 250 PHE 250 402 402 PHE PHE B . n 
C 1 251 GLN 251 403 403 GLN GLN B . n 
C 1 252 PRO 252 404 404 PRO PRO B . n 
C 1 253 GLU 253 405 405 GLU GLU B . n 
C 1 254 ASN 254 406 406 ASN ASN B . n 
C 1 255 SER 255 407 407 SER SER B . n 
C 1 256 MET 256 408 408 MET MET B . n 
C 1 257 LYS 257 409 409 LYS LYS B . n 
C 1 258 LEU 258 410 410 LEU LEU B . n 
C 1 259 THR 259 411 411 THR THR B . n 
C 1 260 PRO 260 412 412 PRO PRO B . n 
C 1 261 LEU 261 413 413 LEU LEU B . n 
C 1 262 VAL 262 414 414 VAL VAL B . n 
C 1 263 LEU 263 415 415 LEU LEU B . n 
C 1 264 GLU 264 416 416 GLU GLU B . n 
C 1 265 VAL 265 417 417 VAL VAL B . n 
C 1 266 PHE 266 418 418 PHE PHE B . n 
C 1 267 GLY 267 419 419 GLY GLY B . n 
C 1 268 ASN 268 420 420 ASN ASN B . n 
C 1 269 GLU 269 421 ?   ?   ?   B . n 
C 1 270 ILE 270 422 ?   ?   ?   B . n 
C 1 271 SER 271 423 ?   ?   ?   B . n 
D 2 1   LYS 1   625 625 LYS LYS D . n 
D 2 2   ASN 2   626 626 ASN ASN D . n 
D 2 3   HIS 3   627 627 HIS HIS D . n 
D 2 4   PRO 4   628 628 PRO PRO D . n 
D 2 5   MET 5   629 629 MET MET D . n 
D 2 6   LEU 6   630 630 LEU LEU D . n 
D 2 7   MET 7   631 631 MET MET D . n 
D 2 8   ASN 8   632 632 ASN ASN D . n 
D 2 9   LEU 9   633 633 LEU LEU D . n 
D 2 10  LEU 10  634 634 LEU LEU D . n 
D 2 11  LYS 11  635 635 LYS LYS D . n 
D 2 12  ASP 12  636 ?   ?   ?   D . n 
D 2 13  ASN 13  637 ?   ?   ?   D . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1L7Z 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1L7Z 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
E 3 A1L7Z 1   501 501 A1L7Z LIG A . 
F 3 A1L7Z 1   501 501 A1L7Z LIG B . 
G 4 HOH   1   601 289 HOH   HOH A . 
G 4 HOH   2   602 73  HOH   HOH A . 
G 4 HOH   3   603 172 HOH   HOH A . 
G 4 HOH   4   604 287 HOH   HOH A . 
G 4 HOH   5   605 186 HOH   HOH A . 
G 4 HOH   6   606 265 HOH   HOH A . 
G 4 HOH   7   607 270 HOH   HOH A . 
G 4 HOH   8   608 43  HOH   HOH A . 
G 4 HOH   9   609 132 HOH   HOH A . 
G 4 HOH   10  610 68  HOH   HOH A . 
G 4 HOH   11  611 215 HOH   HOH A . 
G 4 HOH   12  612 69  HOH   HOH A . 
G 4 HOH   13  613 208 HOH   HOH A . 
G 4 HOH   14  614 232 HOH   HOH A . 
G 4 HOH   15  615 38  HOH   HOH A . 
G 4 HOH   16  616 78  HOH   HOH A . 
G 4 HOH   17  617 310 HOH   HOH A . 
G 4 HOH   18  618 9   HOH   HOH A . 
G 4 HOH   19  619 15  HOH   HOH A . 
G 4 HOH   20  620 100 HOH   HOH A . 
G 4 HOH   21  621 319 HOH   HOH A . 
G 4 HOH   22  622 302 HOH   HOH A . 
G 4 HOH   23  623 54  HOH   HOH A . 
G 4 HOH   24  624 170 HOH   HOH A . 
G 4 HOH   25  625 60  HOH   HOH A . 
G 4 HOH   26  626 199 HOH   HOH A . 
G 4 HOH   27  627 184 HOH   HOH A . 
G 4 HOH   28  628 223 HOH   HOH A . 
G 4 HOH   29  629 2   HOH   HOH A . 
G 4 HOH   30  630 204 HOH   HOH A . 
G 4 HOH   31  631 24  HOH   HOH A . 
G 4 HOH   32  632 95  HOH   HOH A . 
G 4 HOH   33  633 5   HOH   HOH A . 
G 4 HOH   34  634 335 HOH   HOH A . 
G 4 HOH   35  635 226 HOH   HOH A . 
G 4 HOH   36  636 59  HOH   HOH A . 
G 4 HOH   37  637 10  HOH   HOH A . 
G 4 HOH   38  638 308 HOH   HOH A . 
G 4 HOH   39  639 84  HOH   HOH A . 
G 4 HOH   40  640 70  HOH   HOH A . 
G 4 HOH   41  641 142 HOH   HOH A . 
G 4 HOH   42  642 197 HOH   HOH A . 
G 4 HOH   43  643 12  HOH   HOH A . 
G 4 HOH   44  644 52  HOH   HOH A . 
G 4 HOH   45  645 112 HOH   HOH A . 
G 4 HOH   46  646 331 HOH   HOH A . 
G 4 HOH   47  647 18  HOH   HOH A . 
G 4 HOH   48  648 150 HOH   HOH A . 
G 4 HOH   49  649 45  HOH   HOH A . 
G 4 HOH   50  650 135 HOH   HOH A . 
G 4 HOH   51  651 97  HOH   HOH A . 
G 4 HOH   52  652 98  HOH   HOH A . 
G 4 HOH   53  653 175 HOH   HOH A . 
G 4 HOH   54  654 17  HOH   HOH A . 
G 4 HOH   55  655 29  HOH   HOH A . 
G 4 HOH   56  656 27  HOH   HOH A . 
G 4 HOH   57  657 64  HOH   HOH A . 
G 4 HOH   58  658 3   HOH   HOH A . 
G 4 HOH   59  659 320 HOH   HOH A . 
G 4 HOH   60  660 121 HOH   HOH A . 
G 4 HOH   61  661 89  HOH   HOH A . 
G 4 HOH   62  662 200 HOH   HOH A . 
G 4 HOH   63  663 137 HOH   HOH A . 
G 4 HOH   64  664 67  HOH   HOH A . 
G 4 HOH   65  665 141 HOH   HOH A . 
G 4 HOH   66  666 79  HOH   HOH A . 
G 4 HOH   67  667 35  HOH   HOH A . 
G 4 HOH   68  668 28  HOH   HOH A . 
G 4 HOH   69  669 103 HOH   HOH A . 
G 4 HOH   70  670 299 HOH   HOH A . 
G 4 HOH   71  671 55  HOH   HOH A . 
G 4 HOH   72  672 219 HOH   HOH A . 
G 4 HOH   73  673 250 HOH   HOH A . 
G 4 HOH   74  674 6   HOH   HOH A . 
G 4 HOH   75  675 324 HOH   HOH A . 
G 4 HOH   76  676 108 HOH   HOH A . 
G 4 HOH   77  677 157 HOH   HOH A . 
G 4 HOH   78  678 36  HOH   HOH A . 
G 4 HOH   79  679 63  HOH   HOH A . 
G 4 HOH   80  680 339 HOH   HOH A . 
G 4 HOH   81  681 147 HOH   HOH A . 
G 4 HOH   82  682 124 HOH   HOH A . 
G 4 HOH   83  683 148 HOH   HOH A . 
G 4 HOH   84  684 152 HOH   HOH A . 
G 4 HOH   85  685 279 HOH   HOH A . 
G 4 HOH   86  686 268 HOH   HOH A . 
G 4 HOH   87  687 25  HOH   HOH A . 
G 4 HOH   88  688 177 HOH   HOH A . 
G 4 HOH   89  689 107 HOH   HOH A . 
G 4 HOH   90  690 291 HOH   HOH A . 
G 4 HOH   91  691 260 HOH   HOH A . 
G 4 HOH   92  692 22  HOH   HOH A . 
G 4 HOH   93  693 321 HOH   HOH A . 
G 4 HOH   94  694 26  HOH   HOH A . 
G 4 HOH   95  695 115 HOH   HOH A . 
G 4 HOH   96  696 110 HOH   HOH A . 
G 4 HOH   97  697 243 HOH   HOH A . 
G 4 HOH   98  698 297 HOH   HOH A . 
G 4 HOH   99  699 198 HOH   HOH A . 
G 4 HOH   100 700 306 HOH   HOH A . 
G 4 HOH   101 701 196 HOH   HOH A . 
G 4 HOH   102 702 317 HOH   HOH A . 
G 4 HOH   103 703 156 HOH   HOH A . 
G 4 HOH   104 704 294 HOH   HOH A . 
G 4 HOH   105 705 123 HOH   HOH A . 
G 4 HOH   106 706 154 HOH   HOH A . 
G 4 HOH   107 707 239 HOH   HOH A . 
G 4 HOH   108 708 109 HOH   HOH A . 
G 4 HOH   109 709 187 HOH   HOH A . 
G 4 HOH   110 710 245 HOH   HOH A . 
G 4 HOH   111 711 146 HOH   HOH A . 
G 4 HOH   112 712 307 HOH   HOH A . 
G 4 HOH   113 713 315 HOH   HOH A . 
G 4 HOH   114 714 278 HOH   HOH A . 
G 4 HOH   115 715 83  HOH   HOH A . 
G 4 HOH   116 716 262 HOH   HOH A . 
G 4 HOH   117 717 174 HOH   HOH A . 
G 4 HOH   118 718 183 HOH   HOH A . 
G 4 HOH   119 719 129 HOH   HOH A . 
G 4 HOH   120 720 167 HOH   HOH A . 
G 4 HOH   121 721 125 HOH   HOH A . 
G 4 HOH   122 722 126 HOH   HOH A . 
G 4 HOH   123 723 342 HOH   HOH A . 
G 4 HOH   124 724 188 HOH   HOH A . 
G 4 HOH   125 725 276 HOH   HOH A . 
G 4 HOH   126 726 329 HOH   HOH A . 
G 4 HOH   127 727 340 HOH   HOH A . 
G 4 HOH   128 728 75  HOH   HOH A . 
G 4 HOH   129 729 304 HOH   HOH A . 
G 4 HOH   130 730 295 HOH   HOH A . 
G 4 HOH   131 731 338 HOH   HOH A . 
G 4 HOH   132 732 238 HOH   HOH A . 
G 4 HOH   133 733 344 HOH   HOH A . 
G 4 HOH   134 734 241 HOH   HOH A . 
G 4 HOH   135 735 283 HOH   HOH A . 
G 4 HOH   136 736 173 HOH   HOH A . 
G 4 HOH   137 737 282 HOH   HOH A . 
G 4 HOH   138 738 122 HOH   HOH A . 
G 4 HOH   139 739 128 HOH   HOH A . 
G 4 HOH   140 740 259 HOH   HOH A . 
G 4 HOH   141 741 149 HOH   HOH A . 
G 4 HOH   142 742 138 HOH   HOH A . 
G 4 HOH   143 743 341 HOH   HOH A . 
G 4 HOH   144 744 263 HOH   HOH A . 
G 4 HOH   145 745 280 HOH   HOH A . 
G 4 HOH   146 746 34  HOH   HOH A . 
H 4 HOH   1   701 130 HOH   HOH C . 
I 4 HOH   1   601 56  HOH   HOH B . 
I 4 HOH   2   602 201 HOH   HOH B . 
I 4 HOH   3   603 58  HOH   HOH B . 
I 4 HOH   4   604 153 HOH   HOH B . 
I 4 HOH   5   605 202 HOH   HOH B . 
I 4 HOH   6   606 77  HOH   HOH B . 
I 4 HOH   7   607 301 HOH   HOH B . 
I 4 HOH   8   608 44  HOH   HOH B . 
I 4 HOH   9   609 46  HOH   HOH B . 
I 4 HOH   10  610 1   HOH   HOH B . 
I 4 HOH   11  611 180 HOH   HOH B . 
I 4 HOH   12  612 305 HOH   HOH B . 
I 4 HOH   13  613 37  HOH   HOH B . 
I 4 HOH   14  614 168 HOH   HOH B . 
I 4 HOH   15  615 343 HOH   HOH B . 
I 4 HOH   16  616 334 HOH   HOH B . 
I 4 HOH   17  617 209 HOH   HOH B . 
I 4 HOH   18  618 104 HOH   HOH B . 
I 4 HOH   19  619 143 HOH   HOH B . 
I 4 HOH   20  620 85  HOH   HOH B . 
I 4 HOH   21  621 131 HOH   HOH B . 
I 4 HOH   22  622 39  HOH   HOH B . 
I 4 HOH   23  623 206 HOH   HOH B . 
I 4 HOH   24  624 11  HOH   HOH B . 
I 4 HOH   25  625 14  HOH   HOH B . 
I 4 HOH   26  626 229 HOH   HOH B . 
I 4 HOH   27  627 322 HOH   HOH B . 
I 4 HOH   28  628 4   HOH   HOH B . 
I 4 HOH   29  629 314 HOH   HOH B . 
I 4 HOH   30  630 145 HOH   HOH B . 
I 4 HOH   31  631 221 HOH   HOH B . 
I 4 HOH   32  632 7   HOH   HOH B . 
I 4 HOH   33  633 96  HOH   HOH B . 
I 4 HOH   34  634 76  HOH   HOH B . 
I 4 HOH   35  635 87  HOH   HOH B . 
I 4 HOH   36  636 62  HOH   HOH B . 
I 4 HOH   37  637 159 HOH   HOH B . 
I 4 HOH   38  638 255 HOH   HOH B . 
I 4 HOH   39  639 50  HOH   HOH B . 
I 4 HOH   40  640 33  HOH   HOH B . 
I 4 HOH   41  641 8   HOH   HOH B . 
I 4 HOH   42  642 71  HOH   HOH B . 
I 4 HOH   43  643 30  HOH   HOH B . 
I 4 HOH   44  644 290 HOH   HOH B . 
I 4 HOH   45  645 13  HOH   HOH B . 
I 4 HOH   46  646 158 HOH   HOH B . 
I 4 HOH   47  647 136 HOH   HOH B . 
I 4 HOH   48  648 113 HOH   HOH B . 
I 4 HOH   49  649 16  HOH   HOH B . 
I 4 HOH   50  650 82  HOH   HOH B . 
I 4 HOH   51  651 195 HOH   HOH B . 
I 4 HOH   52  652 296 HOH   HOH B . 
I 4 HOH   53  653 72  HOH   HOH B . 
I 4 HOH   54  654 106 HOH   HOH B . 
I 4 HOH   55  655 51  HOH   HOH B . 
I 4 HOH   56  656 176 HOH   HOH B . 
I 4 HOH   57  657 86  HOH   HOH B . 
I 4 HOH   58  658 166 HOH   HOH B . 
I 4 HOH   59  659 91  HOH   HOH B . 
I 4 HOH   60  660 40  HOH   HOH B . 
I 4 HOH   61  661 32  HOH   HOH B . 
I 4 HOH   62  662 258 HOH   HOH B . 
I 4 HOH   63  663 214 HOH   HOH B . 
I 4 HOH   64  664 99  HOH   HOH B . 
I 4 HOH   65  665 21  HOH   HOH B . 
I 4 HOH   66  666 327 HOH   HOH B . 
I 4 HOH   67  667 333 HOH   HOH B . 
I 4 HOH   68  668 57  HOH   HOH B . 
I 4 HOH   69  669 309 HOH   HOH B . 
I 4 HOH   70  670 65  HOH   HOH B . 
I 4 HOH   71  671 101 HOH   HOH B . 
I 4 HOH   72  672 31  HOH   HOH B . 
I 4 HOH   73  673 312 HOH   HOH B . 
I 4 HOH   74  674 127 HOH   HOH B . 
I 4 HOH   75  675 316 HOH   HOH B . 
I 4 HOH   76  676 90  HOH   HOH B . 
I 4 HOH   77  677 120 HOH   HOH B . 
I 4 HOH   78  678 328 HOH   HOH B . 
I 4 HOH   79  679 151 HOH   HOH B . 
I 4 HOH   80  680 235 HOH   HOH B . 
I 4 HOH   81  681 20  HOH   HOH B . 
I 4 HOH   82  682 74  HOH   HOH B . 
I 4 HOH   83  683 49  HOH   HOH B . 
I 4 HOH   84  684 53  HOH   HOH B . 
I 4 HOH   85  685 61  HOH   HOH B . 
I 4 HOH   86  686 80  HOH   HOH B . 
I 4 HOH   87  687 66  HOH   HOH B . 
I 4 HOH   88  688 249 HOH   HOH B . 
I 4 HOH   89  689 189 HOH   HOH B . 
I 4 HOH   90  690 162 HOH   HOH B . 
I 4 HOH   91  691 41  HOH   HOH B . 
I 4 HOH   92  692 42  HOH   HOH B . 
I 4 HOH   93  693 140 HOH   HOH B . 
I 4 HOH   94  694 269 HOH   HOH B . 
I 4 HOH   95  695 134 HOH   HOH B . 
I 4 HOH   96  696 119 HOH   HOH B . 
I 4 HOH   97  697 181 HOH   HOH B . 
I 4 HOH   98  698 274 HOH   HOH B . 
I 4 HOH   99  699 318 HOH   HOH B . 
I 4 HOH   100 700 336 HOH   HOH B . 
I 4 HOH   101 701 266 HOH   HOH B . 
I 4 HOH   102 702 298 HOH   HOH B . 
I 4 HOH   103 703 293 HOH   HOH B . 
I 4 HOH   104 704 165 HOH   HOH B . 
I 4 HOH   105 705 144 HOH   HOH B . 
I 4 HOH   106 706 325 HOH   HOH B . 
I 4 HOH   107 707 102 HOH   HOH B . 
I 4 HOH   108 708 163 HOH   HOH B . 
I 4 HOH   109 709 94  HOH   HOH B . 
I 4 HOH   110 710 272 HOH   HOH B . 
I 4 HOH   111 711 240 HOH   HOH B . 
I 4 HOH   112 712 111 HOH   HOH B . 
I 4 HOH   113 713 47  HOH   HOH B . 
I 4 HOH   114 714 252 HOH   HOH B . 
I 4 HOH   115 715 257 HOH   HOH B . 
I 4 HOH   116 716 185 HOH   HOH B . 
I 4 HOH   117 717 330 HOH   HOH B . 
I 4 HOH   118 718 271 HOH   HOH B . 
I 4 HOH   119 719 313 HOH   HOH B . 
I 4 HOH   120 720 116 HOH   HOH B . 
I 4 HOH   121 721 286 HOH   HOH B . 
I 4 HOH   122 722 212 HOH   HOH B . 
I 4 HOH   123 723 323 HOH   HOH B . 
I 4 HOH   124 724 292 HOH   HOH B . 
I 4 HOH   125 725 256 HOH   HOH B . 
I 4 HOH   126 726 88  HOH   HOH B . 
I 4 HOH   127 727 300 HOH   HOH B . 
I 4 HOH   128 728 284 HOH   HOH B . 
I 4 HOH   129 729 93  HOH   HOH B . 
I 4 HOH   130 730 160 HOH   HOH B . 
I 4 HOH   131 731 303 HOH   HOH B . 
I 4 HOH   132 732 92  HOH   HOH B . 
I 4 HOH   133 733 326 HOH   HOH B . 
I 4 HOH   134 734 346 HOH   HOH B . 
I 4 HOH   135 735 332 HOH   HOH B . 
I 4 HOH   136 736 273 HOH   HOH B . 
I 4 HOH   137 737 237 HOH   HOH B . 
I 4 HOH   138 738 23  HOH   HOH B . 
I 4 HOH   139 739 216 HOH   HOH B . 
I 4 HOH   140 740 139 HOH   HOH B . 
I 4 HOH   141 741 133 HOH   HOH B . 
I 4 HOH   142 742 213 HOH   HOH B . 
I 4 HOH   143 743 210 HOH   HOH B . 
I 4 HOH   144 744 285 HOH   HOH B . 
I 4 HOH   145 745 81  HOH   HOH B . 
I 4 HOH   146 746 345 HOH   HOH B . 
I 4 HOH   147 747 117 HOH   HOH B . 
I 4 HOH   148 748 105 HOH   HOH B . 
J 4 HOH   1   701 337 HOH   HOH D . 
J 4 HOH   2   702 48  HOH   HOH D . 
J 4 HOH   3   703 19  HOH   HOH D . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.14_3260 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .         2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .         3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? .         4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   94.819 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9M12 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     45.890 
_cell.length_a_esd                 ? 
_cell.length_b                     44.980 
_cell.length_b_esd                 ? 
_cell.length_c                     128.710 
_cell.length_c_esd                 ? 
_cell.volume                       264735.311 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9M12 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            'P 2yb' 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9M12 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.06 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          40.22 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'PEG 3350, magnesium formate dihydrate, pH 7.' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-05-16 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.0 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SPRING-8 BEAMLINE BL45XU' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.0 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL45XU 
_diffrn_source.pdbx_synchrotron_site       SPring-8 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9M12 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.86 
_reflns.d_resolution_low                               45.74 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     44422 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          8.4 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.995 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.25 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.86 
_reflns_shell.d_res_low                                     1.97 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.5 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             6961 
_reflns_shell.percent_possible_obs                          100 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.588 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  2.45 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               28.46 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9M12 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.86 
_refine.ls_d_res_low                             45.73 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     44285 
_refine.ls_number_reflns_R_free                  2025 
_refine.ls_number_reflns_R_work                  42260 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.65 
_refine.ls_percent_reflns_R_free                 4.57 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1911 
_refine.ls_R_factor_R_free                       0.2171 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1899 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.correlation_coeff_I_to_Fcsqd_work        ? 
_refine.correlation_coeff_I_to_Fcsqd_free        ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      2ZLC 
_refine.pdbx_stereochemistry_target_values       'CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 22.1091 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2247 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.86 
_refine_hist.d_res_low                        45.73 
_refine_hist.number_atoms_solvent             298 
_refine_hist.number_atoms_total               4400 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4030 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         72 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0051  ? 4387 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.7987  ? 5959 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.2042  ? 659  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0043  ? 768  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 22.9304 ? 1699 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.correlation_coeff_Fo_to_Fc 
_refine_ls_shell.correlation_coeff_Fo_to_Fc_free 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_work 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_free 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.86 1.91  . . 161 2950 98.39  . . . . 0.2926 . . . . . . . . . . . . . . . 0.3412 
'X-RAY DIFFRACTION' 1.91 1.96  . . 130 2987 98.64  . . . . 0.2651 . . . . . . . . . . . . . . . 0.3355 
'X-RAY DIFFRACTION' 1.96 2.02  . . 132 2995 99.87  . . . . 0.2265 . . . . . . . . . . . . . . . 0.2184 
'X-RAY DIFFRACTION' 2.02 2.08  . . 150 3001 99.75  . . . . 0.2062 . . . . . . . . . . . . . . . 0.2368 
'X-RAY DIFFRACTION' 2.08 2.16  . . 147 2993 100.00 . . . . 0.1971 . . . . . . . . . . . . . . . 0.2524 
'X-RAY DIFFRACTION' 2.16 2.24  . . 134 3005 100.00 . . . . 0.1901 . . . . . . . . . . . . . . . 0.2106 
'X-RAY DIFFRACTION' 2.24 2.34  . . 151 3004 99.97  . . . . 0.1812 . . . . . . . . . . . . . . . 0.2521 
'X-RAY DIFFRACTION' 2.34 2.47  . . 144 3025 99.94  . . . . 0.1814 . . . . . . . . . . . . . . . 0.1949 
'X-RAY DIFFRACTION' 2.47 2.62  . . 147 3004 99.90  . . . . 0.1748 . . . . . . . . . . . . . . . 0.2172 
'X-RAY DIFFRACTION' 2.62 2.82  . . 145 3031 99.84  . . . . 0.1713 . . . . . . . . . . . . . . . 0.2218 
'X-RAY DIFFRACTION' 2.82 3.11  . . 138 3023 99.97  . . . . 0.1777 . . . . . . . . . . . . . . . 0.1982 
'X-RAY DIFFRACTION' 3.11 3.56  . . 145 3056 99.88  . . . . 0.1709 . . . . . . . . . . . . . . . 0.1774 
'X-RAY DIFFRACTION' 3.56 4.48  . . 153 3048 99.78  . . . . 0.1714 . . . . . . . . . . . . . . . 0.1742 
'X-RAY DIFFRACTION' 4.48 45.73 . . 148 3138 99.33  . . . . 0.2060 . . . . . . . . . . . . . . . 0.2413 
# 
_struct.entry_id                     9M12 
_struct.title                        'Vitamin D receptor complex with a bis(3-ethylphenyl)dimethylsilane derivative' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9M12 
_struct_keywords.text            'Vitamin D receptor, TRANSCRIPTION' 
_struct_keywords.pdbx_keywords   TRANSCRIPTION 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 1 ? 
D N N 2 ? 
E N N 3 ? 
F N N 3 ? 
G N N 4 ? 
H N N 4 ? 
I N N 4 ? 
J N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP VDR_RAT    P13053 ? 1 
;LKDSLRPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMDGSTGSYSPRPTLSFSGNSSSSSSDLYTTSLDMMEP
SGFSNLDLNGEDSDDPSVTLDLSPLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSF
TMDDMSWDCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRL
SNTLQTYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGNEIS
;
116 
2 UNP MED1_HUMAN Q15648 ? 2 KNHPMLMNLLKDN 640 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9M12 A 11 ? 271 ? P13053 116 ? 423 ? 116 423 
2 2 9M12 C 1  ? 13  ? Q15648 640 ? 652 ? 625 637 
3 1 9M12 B 11 ? 271 ? P13053 116 ? 423 ? 116 423 
4 2 9M12 D 1  ? 13  ? Q15648 640 ? 652 ? 625 637 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9M12 GLY A 1  ? UNP P13053 ?   ?   'expression tag' 106 1   
1 9M12 SER A 2  ? UNP P13053 ?   ?   'expression tag' 107 2   
1 9M12 HIS A 3  ? UNP P13053 ?   ?   'expression tag' 108 3   
1 9M12 MET A 4  ? UNP P13053 ?   ?   'expression tag' 109 4   
1 9M12 GLY A 5  ? UNP P13053 ?   ?   'expression tag' 110 5   
1 9M12 SER A 6  ? UNP P13053 ?   ?   'expression tag' 111 6   
1 9M12 PRO A 7  ? UNP P13053 ?   ?   'expression tag' 112 7   
1 9M12 ASN A 8  ? UNP P13053 ?   ?   'expression tag' 113 8   
1 9M12 SER A 9  ? UNP P13053 ?   ?   'expression tag' 114 9   
1 9M12 PRO A 10 ? UNP P13053 ?   ?   'expression tag' 115 10  
1 9M12 ?   A ?  ? UNP P13053 TYR 166 deletion         ?   11  
1 9M12 ?   A ?  ? UNP P13053 SER 167 deletion         ?   12  
1 9M12 ?   A ?  ? UNP P13053 PRO 168 deletion         ?   13  
1 9M12 ?   A ?  ? UNP P13053 ARG 169 deletion         ?   14  
1 9M12 ?   A ?  ? UNP P13053 PRO 170 deletion         ?   15  
1 9M12 ?   A ?  ? UNP P13053 THR 171 deletion         ?   16  
1 9M12 ?   A ?  ? UNP P13053 LEU 172 deletion         ?   17  
1 9M12 ?   A ?  ? UNP P13053 SER 173 deletion         ?   18  
1 9M12 ?   A ?  ? UNP P13053 PHE 174 deletion         ?   19  
1 9M12 ?   A ?  ? UNP P13053 SER 175 deletion         ?   20  
1 9M12 ?   A ?  ? UNP P13053 GLY 176 deletion         ?   21  
1 9M12 ?   A ?  ? UNP P13053 ASN 177 deletion         ?   22  
1 9M12 ?   A ?  ? UNP P13053 SER 178 deletion         ?   23  
1 9M12 ?   A ?  ? UNP P13053 SER 179 deletion         ?   24  
1 9M12 ?   A ?  ? UNP P13053 SER 180 deletion         ?   25  
1 9M12 ?   A ?  ? UNP P13053 SER 181 deletion         ?   26  
1 9M12 ?   A ?  ? UNP P13053 SER 182 deletion         ?   27  
1 9M12 ?   A ?  ? UNP P13053 SER 183 deletion         ?   28  
1 9M12 ?   A ?  ? UNP P13053 ASP 184 deletion         ?   29  
1 9M12 ?   A ?  ? UNP P13053 LEU 185 deletion         ?   30  
1 9M12 ?   A ?  ? UNP P13053 TYR 186 deletion         ?   31  
1 9M12 ?   A ?  ? UNP P13053 THR 187 deletion         ?   32  
1 9M12 ?   A ?  ? UNP P13053 THR 188 deletion         ?   33  
1 9M12 ?   A ?  ? UNP P13053 SER 189 deletion         ?   34  
1 9M12 ?   A ?  ? UNP P13053 LEU 190 deletion         ?   35  
1 9M12 ?   A ?  ? UNP P13053 ASP 191 deletion         ?   36  
1 9M12 ?   A ?  ? UNP P13053 MET 192 deletion         ?   37  
1 9M12 ?   A ?  ? UNP P13053 MET 193 deletion         ?   38  
1 9M12 ?   A ?  ? UNP P13053 GLU 194 deletion         ?   39  
1 9M12 ?   A ?  ? UNP P13053 PRO 195 deletion         ?   40  
1 9M12 ?   A ?  ? UNP P13053 SER 196 deletion         ?   41  
1 9M12 ?   A ?  ? UNP P13053 GLY 197 deletion         ?   42  
1 9M12 ?   A ?  ? UNP P13053 PHE 198 deletion         ?   43  
1 9M12 ?   A ?  ? UNP P13053 SER 199 deletion         ?   44  
1 9M12 ?   A ?  ? UNP P13053 ASN 200 deletion         ?   45  
1 9M12 ?   A ?  ? UNP P13053 LEU 201 deletion         ?   46  
1 9M12 ?   A ?  ? UNP P13053 ASP 202 deletion         ?   47  
1 9M12 ?   A ?  ? UNP P13053 LEU 203 deletion         ?   48  
1 9M12 ?   A ?  ? UNP P13053 ASN 204 deletion         ?   49  
1 9M12 ?   A ?  ? UNP P13053 GLY 205 deletion         ?   50  
1 9M12 ?   A ?  ? UNP P13053 GLU 206 deletion         ?   51  
1 9M12 ?   A ?  ? UNP P13053 ASP 207 deletion         ?   52  
1 9M12 ?   A ?  ? UNP P13053 SER 208 deletion         ?   53  
1 9M12 ?   A ?  ? UNP P13053 ASP 209 deletion         ?   54  
1 9M12 ?   A ?  ? UNP P13053 ASP 210 deletion         ?   55  
1 9M12 ?   A ?  ? UNP P13053 PRO 211 deletion         ?   56  
1 9M12 ?   A ?  ? UNP P13053 SER 212 deletion         ?   57  
3 9M12 GLY B 1  ? UNP P13053 ?   ?   'expression tag' 106 58  
3 9M12 SER B 2  ? UNP P13053 ?   ?   'expression tag' 107 59  
3 9M12 HIS B 3  ? UNP P13053 ?   ?   'expression tag' 108 60  
3 9M12 MET B 4  ? UNP P13053 ?   ?   'expression tag' 109 61  
3 9M12 GLY B 5  ? UNP P13053 ?   ?   'expression tag' 110 62  
3 9M12 SER B 6  ? UNP P13053 ?   ?   'expression tag' 111 63  
3 9M12 PRO B 7  ? UNP P13053 ?   ?   'expression tag' 112 64  
3 9M12 ASN B 8  ? UNP P13053 ?   ?   'expression tag' 113 65  
3 9M12 SER B 9  ? UNP P13053 ?   ?   'expression tag' 114 66  
3 9M12 PRO B 10 ? UNP P13053 ?   ?   'expression tag' 115 67  
3 9M12 ?   B ?  ? UNP P13053 TYR 166 deletion         ?   68  
3 9M12 ?   B ?  ? UNP P13053 SER 167 deletion         ?   69  
3 9M12 ?   B ?  ? UNP P13053 PRO 168 deletion         ?   70  
3 9M12 ?   B ?  ? UNP P13053 ARG 169 deletion         ?   71  
3 9M12 ?   B ?  ? UNP P13053 PRO 170 deletion         ?   72  
3 9M12 ?   B ?  ? UNP P13053 THR 171 deletion         ?   73  
3 9M12 ?   B ?  ? UNP P13053 LEU 172 deletion         ?   74  
3 9M12 ?   B ?  ? UNP P13053 SER 173 deletion         ?   75  
3 9M12 ?   B ?  ? UNP P13053 PHE 174 deletion         ?   76  
3 9M12 ?   B ?  ? UNP P13053 SER 175 deletion         ?   77  
3 9M12 ?   B ?  ? UNP P13053 GLY 176 deletion         ?   78  
3 9M12 ?   B ?  ? UNP P13053 ASN 177 deletion         ?   79  
3 9M12 ?   B ?  ? UNP P13053 SER 178 deletion         ?   80  
3 9M12 ?   B ?  ? UNP P13053 SER 179 deletion         ?   81  
3 9M12 ?   B ?  ? UNP P13053 SER 180 deletion         ?   82  
3 9M12 ?   B ?  ? UNP P13053 SER 181 deletion         ?   83  
3 9M12 ?   B ?  ? UNP P13053 SER 182 deletion         ?   84  
3 9M12 ?   B ?  ? UNP P13053 SER 183 deletion         ?   85  
3 9M12 ?   B ?  ? UNP P13053 ASP 184 deletion         ?   86  
3 9M12 ?   B ?  ? UNP P13053 LEU 185 deletion         ?   87  
3 9M12 ?   B ?  ? UNP P13053 TYR 186 deletion         ?   88  
3 9M12 ?   B ?  ? UNP P13053 THR 187 deletion         ?   89  
3 9M12 ?   B ?  ? UNP P13053 THR 188 deletion         ?   90  
3 9M12 ?   B ?  ? UNP P13053 SER 189 deletion         ?   91  
3 9M12 ?   B ?  ? UNP P13053 LEU 190 deletion         ?   92  
3 9M12 ?   B ?  ? UNP P13053 ASP 191 deletion         ?   93  
3 9M12 ?   B ?  ? UNP P13053 MET 192 deletion         ?   94  
3 9M12 ?   B ?  ? UNP P13053 MET 193 deletion         ?   95  
3 9M12 ?   B ?  ? UNP P13053 GLU 194 deletion         ?   96  
3 9M12 ?   B ?  ? UNP P13053 PRO 195 deletion         ?   97  
3 9M12 ?   B ?  ? UNP P13053 SER 196 deletion         ?   98  
3 9M12 ?   B ?  ? UNP P13053 GLY 197 deletion         ?   99  
3 9M12 ?   B ?  ? UNP P13053 PHE 198 deletion         ?   100 
3 9M12 ?   B ?  ? UNP P13053 SER 199 deletion         ?   101 
3 9M12 ?   B ?  ? UNP P13053 ASN 200 deletion         ?   102 
3 9M12 ?   B ?  ? UNP P13053 LEU 201 deletion         ?   103 
3 9M12 ?   B ?  ? UNP P13053 ASP 202 deletion         ?   104 
3 9M12 ?   B ?  ? UNP P13053 LEU 203 deletion         ?   105 
3 9M12 ?   B ?  ? UNP P13053 ASN 204 deletion         ?   106 
3 9M12 ?   B ?  ? UNP P13053 GLY 205 deletion         ?   107 
3 9M12 ?   B ?  ? UNP P13053 GLU 206 deletion         ?   108 
3 9M12 ?   B ?  ? UNP P13053 ASP 207 deletion         ?   109 
3 9M12 ?   B ?  ? UNP P13053 SER 208 deletion         ?   110 
3 9M12 ?   B ?  ? UNP P13053 ASP 209 deletion         ?   111 
3 9M12 ?   B ?  ? UNP P13053 ASP 210 deletion         ?   112 
3 9M12 ?   B ?  ? UNP P13053 PRO 211 deletion         ?   113 
3 9M12 ?   B ?  ? UNP P13053 SER 212 deletion         ?   114 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_and_software_defined_assembly PISA dimeric 2 
2 author_and_software_defined_assembly PISA dimeric 2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1160  ? 
1 MORE         -9    ? 
1 'SSA (A^2)'  11920 ? 
2 'ABSA (A^2)' 1090  ? 
2 MORE         -8    ? 
2 'SSA (A^2)'  12120 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,B,E,G,H 
2 1 C,D,F,I,J 
# 
loop_
_pdbx_struct_assembly_auth_evidence.id 
_pdbx_struct_assembly_auth_evidence.assembly_id 
_pdbx_struct_assembly_auth_evidence.experimental_support 
_pdbx_struct_assembly_auth_evidence.details 
1 1 'gel filtration' ? 
2 2 'gel filtration' ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 20  ? TYR A 38  ? SER A 125 TYR A 143 1 ? 19 
HELX_P HELX_P2  AA2 TYR A 42  ? PHE A 48  ? TYR A 147 PHE A 153 5 ? 7  
HELX_P HELX_P3  AA3 MET A 70  ? LYS A 90  ? MET A 222 LYS A 242 1 ? 21 
HELX_P HELX_P4  AA4 GLY A 94  ? LEU A 98  ? GLY A 246 LEU A 250 5 ? 5  
HELX_P HELX_P5  AA5 THR A 99  ? ASN A 120 ? THR A 251 ASN A 272 1 ? 22 
HELX_P HELX_P6  AA6 ASP A 140 ? LYS A 146 ? ASP A 292 LYS A 298 1 ? 7  
HELX_P HELX_P7  AA7 THR A 150 ? LYS A 166 ? THR A 302 LYS A 318 1 ? 17 
HELX_P HELX_P8  AA8 HIS A 170 ? VAL A 183 ? HIS A 322 VAL A 335 1 ? 14 
HELX_P HELX_P9  AA9 ASP A 192 ? HIS A 215 ? ASP A 344 HIS A 367 1 ? 24 
HELX_P HELX_P10 AB1 PRO A 218 ? PHE A 250 ? PRO A 370 PHE A 402 1 ? 33 
HELX_P HELX_P11 AB2 GLN A 251 ? MET A 256 ? GLN A 403 MET A 408 1 ? 6  
HELX_P HELX_P12 AB3 THR A 259 ? GLY A 267 ? THR A 411 GLY A 419 1 ? 9  
HELX_P HELX_P13 AB4 HIS B 3   ? LYS B 11  ? HIS C 627 LYS C 635 1 ? 9  
HELX_P HELX_P14 AB5 SER C 20  ? TYR C 38  ? SER B 125 TYR B 143 1 ? 19 
HELX_P HELX_P15 AB6 TYR C 42  ? PHE C 48  ? TYR B 147 PHE B 153 5 ? 7  
HELX_P HELX_P16 AB7 MET C 70  ? MET C 91  ? MET B 222 MET B 243 1 ? 22 
HELX_P HELX_P17 AB8 GLY C 94  ? LEU C 98  ? GLY B 246 LEU B 250 5 ? 5  
HELX_P HELX_P18 AB9 THR C 99  ? SER C 119 ? THR B 251 SER B 271 1 ? 21 
HELX_P HELX_P19 AC1 ASP C 140 ? LYS C 146 ? ASP B 292 LYS B 298 1 ? 7  
HELX_P HELX_P20 AC2 THR C 150 ? LEU C 167 ? THR B 302 LEU B 319 1 ? 18 
HELX_P HELX_P21 AC3 HIS C 170 ? VAL C 183 ? HIS B 322 VAL B 335 1 ? 14 
HELX_P HELX_P22 AC4 ASP C 192 ? HIS C 215 ? ASP B 344 HIS B 367 1 ? 24 
HELX_P HELX_P23 AC5 PRO C 218 ? GLN C 251 ? PRO B 370 GLN B 403 1 ? 34 
HELX_P HELX_P24 AC6 GLN C 251 ? MET C 256 ? GLN B 403 MET B 408 1 ? 6  
HELX_P HELX_P25 AC7 THR C 259 ? PHE C 266 ? THR B 411 PHE B 418 1 ? 8  
HELX_P HELX_P26 AC8 HIS D 3   ? LYS D 11  ? HIS D 627 LYS D 635 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 PRO 217 A . ? PRO 369 A PRO 218 A ? PRO 370 A 1 1.20 
2 PRO 217 C . ? PRO 369 B PRO 218 C ? PRO 370 B 1 1.08 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 3 ? 
AA2 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 123 ? THR A 124 ? PHE A 275 THR A 276 
AA1 2 SER A 129 ? ASP A 131 ? SER A 281 ASP A 283 
AA1 3 LYS A 138 ? TYR A 139 ? LYS A 290 TYR A 291 
AA2 1 PHE C 123 ? THR C 124 ? PHE B 275 THR B 276 
AA2 2 SER C 129 ? ASP C 131 ? SER B 281 ASP B 283 
AA2 3 LYS C 138 ? TYR C 139 ? LYS B 290 TYR B 291 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N THR A 124 ? N THR A 276 O SER A 129 ? O SER A 281 
AA1 2 3 N TRP A 130 ? N TRP A 282 O TYR A 139 ? O TYR A 291 
AA2 1 2 N THR C 124 ? N THR B 276 O SER C 129 ? O SER B 281 
AA2 2 3 N TRP C 130 ? N TRP B 282 O TYR C 139 ? O TYR B 291 
# 
_pdbx_entry_details.entry_id                   9M12 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 TYR A 289 ? ? -99.73  36.44 
2 1 ASP B 279 ? ? -141.86 23.90 
3 1 ASP B 279 ? ? -141.86 23.81 
4 1 TYR B 289 ? ? -97.81  33.41 
5 1 ASP B 344 ? ? -101.09 66.84 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 106 ? A GLY 1   
2  1 Y 1 A SER 107 ? A SER 2   
3  1 Y 1 A HIS 108 ? A HIS 3   
4  1 Y 1 A MET 109 ? A MET 4   
5  1 Y 1 A GLY 110 ? A GLY 5   
6  1 Y 1 A SER 111 ? A SER 6   
7  1 Y 1 A PRO 112 ? A PRO 7   
8  1 Y 1 A ASN 113 ? A ASN 8   
9  1 Y 1 A SER 114 ? A SER 9   
10 1 Y 1 A PRO 115 ? A PRO 10  
11 1 Y 1 A LEU 116 ? A LEU 11  
12 1 Y 1 A LYS 117 ? A LYS 12  
13 1 Y 1 A ASP 118 ? A ASP 13  
14 1 Y 1 A SER 119 ? A SER 14  
15 1 Y 1 A LEU 120 ? A LEU 15  
16 1 Y 1 A ARG 121 ? A ARG 16  
17 1 Y 1 A PRO 122 ? A PRO 17  
18 1 Y 1 A ASP 207 ? A ASP 55  
19 1 Y 1 A GLY 208 ? A GLY 56  
20 1 Y 1 A SER 209 ? A SER 57  
21 1 Y 1 A THR 210 ? A THR 58  
22 1 Y 1 A GLY 211 ? A GLY 59  
23 1 Y 1 A SER 212 ? A SER 60  
24 1 Y 1 A VAL 213 ? A VAL 61  
25 1 Y 1 A THR 214 ? A THR 62  
26 1 Y 1 A LEU 215 ? A LEU 63  
27 1 Y 1 A ASP 216 ? A ASP 64  
28 1 Y 1 A LEU 217 ? A LEU 65  
29 1 Y 1 A GLU 421 ? A GLU 269 
30 1 Y 1 A ILE 422 ? A ILE 270 
31 1 Y 1 A SER 423 ? A SER 271 
32 1 Y 1 C ASP 636 ? B ASP 12  
33 1 Y 1 C ASN 637 ? B ASN 13  
34 1 Y 1 B GLY 106 ? C GLY 1   
35 1 Y 1 B SER 107 ? C SER 2   
36 1 Y 1 B HIS 108 ? C HIS 3   
37 1 Y 1 B MET 109 ? C MET 4   
38 1 Y 1 B GLY 110 ? C GLY 5   
39 1 Y 1 B SER 111 ? C SER 6   
40 1 Y 1 B PRO 112 ? C PRO 7   
41 1 Y 1 B ASN 113 ? C ASN 8   
42 1 Y 1 B SER 114 ? C SER 9   
43 1 Y 1 B PRO 115 ? C PRO 10  
44 1 Y 1 B LEU 116 ? C LEU 11  
45 1 Y 1 B LYS 117 ? C LYS 12  
46 1 Y 1 B ASP 118 ? C ASP 13  
47 1 Y 1 B SER 119 ? C SER 14  
48 1 Y 1 B LEU 120 ? C LEU 15  
49 1 Y 1 B ARG 121 ? C ARG 16  
50 1 Y 1 B PRO 122 ? C PRO 17  
51 1 Y 1 B ASP 207 ? C ASP 55  
52 1 Y 1 B GLY 208 ? C GLY 56  
53 1 Y 1 B SER 209 ? C SER 57  
54 1 Y 1 B THR 210 ? C THR 58  
55 1 Y 1 B GLY 211 ? C GLY 59  
56 1 Y 1 B SER 212 ? C SER 60  
57 1 Y 1 B VAL 213 ? C VAL 61  
58 1 Y 1 B THR 214 ? C THR 62  
59 1 Y 1 B LEU 215 ? C LEU 63  
60 1 Y 1 B ASP 216 ? C ASP 64  
61 1 Y 1 B LEU 217 ? C LEU 65  
62 1 Y 1 B GLU 421 ? C GLU 269 
63 1 Y 1 B ILE 422 ? C ILE 270 
64 1 Y 1 B SER 423 ? C SER 271 
65 1 Y 1 D ASP 636 ? D ASP 12  
66 1 Y 1 D ASN 637 ? D ASN 13  
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1L7Z C10  C  Y N 1   
A1L7Z C13  C  Y N 2   
A1L7Z C15  C  N N 3   
A1L7Z C20  C  N N 4   
A1L7Z C21  C  N N 5   
A1L7Z C22  C  N N 6   
A1L7Z C24  C  N N 7   
A1L7Z C26  C  N N 8   
A1L7Z C28  C  N N 9   
A1L7Z C01  C  Y N 10  
A1L7Z C02  C  Y N 11  
A1L7Z C03  C  Y N 12  
A1L7Z C04  C  Y N 13  
A1L7Z C05  C  Y N 14  
A1L7Z C06  C  Y N 15  
A1L7Z C08  C  Y N 16  
A1L7Z C09  C  Y N 17  
A1L7Z C11  C  Y N 18  
A1L7Z C12  C  Y N 19  
A1L7Z C14  C  N N 20  
A1L7Z C18  C  N N 21  
A1L7Z C19  C  N S 22  
A1L7Z C23  C  N N 23  
A1L7Z C25  C  N N 24  
A1L7Z C27  C  N N 25  
A1L7Z C31  C  N N 26  
A1L7Z C32  C  N N 27  
A1L7Z C35  C  N N 28  
A1L7Z C36  C  N N 29  
A1L7Z O16  O  N N 30  
A1L7Z O17  O  N N 31  
A1L7Z O29  O  N N 32  
A1L7Z O30  O  N N 33  
A1L7Z O33  O  N N 34  
A1L7Z O34  O  N N 35  
A1L7Z SI07 SI N N 36  
A1L7Z H131 H  N N 37  
A1L7Z H153 H  N N 38  
A1L7Z H151 H  N N 39  
A1L7Z H152 H  N N 40  
A1L7Z H201 H  N N 41  
A1L7Z H202 H  N N 42  
A1L7Z H211 H  N N 43  
A1L7Z H212 H  N N 44  
A1L7Z H262 H  N N 45  
A1L7Z H261 H  N N 46  
A1L7Z H283 H  N N 47  
A1L7Z H282 H  N N 48  
A1L7Z H281 H  N N 49  
A1L7Z H011 H  N N 50  
A1L7Z H041 H  N N 51  
A1L7Z H061 H  N N 52  
A1L7Z H091 H  N N 53  
A1L7Z H121 H  N N 54  
A1L7Z H141 H  N N 55  
A1L7Z H143 H  N N 56  
A1L7Z H142 H  N N 57  
A1L7Z H182 H  N N 58  
A1L7Z H181 H  N N 59  
A1L7Z H191 H  N N 60  
A1L7Z H232 H  N N 61  
A1L7Z H231 H  N N 62  
A1L7Z H252 H  N N 63  
A1L7Z H251 H  N N 64  
A1L7Z H272 H  N N 65  
A1L7Z H273 H  N N 66  
A1L7Z H271 H  N N 67  
A1L7Z H312 H  N N 68  
A1L7Z H311 H  N N 69  
A1L7Z H321 H  N N 70  
A1L7Z H322 H  N N 71  
A1L7Z H351 H  N N 72  
A1L7Z H352 H  N N 73  
A1L7Z H353 H  N N 74  
A1L7Z H363 H  N N 75  
A1L7Z H362 H  N N 76  
A1L7Z H361 H  N N 77  
A1L7Z H291 H  N N 78  
A1L7Z H1   H  N N 79  
A1L7Z H341 H  N N 80  
ALA   N    N  N N 81  
ALA   CA   C  N S 82  
ALA   C    C  N N 83  
ALA   O    O  N N 84  
ALA   CB   C  N N 85  
ALA   OXT  O  N N 86  
ALA   H    H  N N 87  
ALA   H2   H  N N 88  
ALA   HA   H  N N 89  
ALA   HB1  H  N N 90  
ALA   HB2  H  N N 91  
ALA   HB3  H  N N 92  
ALA   HXT  H  N N 93  
ARG   N    N  N N 94  
ARG   CA   C  N S 95  
ARG   C    C  N N 96  
ARG   O    O  N N 97  
ARG   CB   C  N N 98  
ARG   CG   C  N N 99  
ARG   CD   C  N N 100 
ARG   NE   N  N N 101 
ARG   CZ   C  N N 102 
ARG   NH1  N  N N 103 
ARG   NH2  N  N N 104 
ARG   OXT  O  N N 105 
ARG   H    H  N N 106 
ARG   H2   H  N N 107 
ARG   HA   H  N N 108 
ARG   HB2  H  N N 109 
ARG   HB3  H  N N 110 
ARG   HG2  H  N N 111 
ARG   HG3  H  N N 112 
ARG   HD2  H  N N 113 
ARG   HD3  H  N N 114 
ARG   HE   H  N N 115 
ARG   HH11 H  N N 116 
ARG   HH12 H  N N 117 
ARG   HH21 H  N N 118 
ARG   HH22 H  N N 119 
ARG   HXT  H  N N 120 
ASN   N    N  N N 121 
ASN   CA   C  N S 122 
ASN   C    C  N N 123 
ASN   O    O  N N 124 
ASN   CB   C  N N 125 
ASN   CG   C  N N 126 
ASN   OD1  O  N N 127 
ASN   ND2  N  N N 128 
ASN   OXT  O  N N 129 
ASN   H    H  N N 130 
ASN   H2   H  N N 131 
ASN   HA   H  N N 132 
ASN   HB2  H  N N 133 
ASN   HB3  H  N N 134 
ASN   HD21 H  N N 135 
ASN   HD22 H  N N 136 
ASN   HXT  H  N N 137 
ASP   N    N  N N 138 
ASP   CA   C  N S 139 
ASP   C    C  N N 140 
ASP   O    O  N N 141 
ASP   CB   C  N N 142 
ASP   CG   C  N N 143 
ASP   OD1  O  N N 144 
ASP   OD2  O  N N 145 
ASP   OXT  O  N N 146 
ASP   H    H  N N 147 
ASP   H2   H  N N 148 
ASP   HA   H  N N 149 
ASP   HB2  H  N N 150 
ASP   HB3  H  N N 151 
ASP   HD2  H  N N 152 
ASP   HXT  H  N N 153 
CYS   N    N  N N 154 
CYS   CA   C  N R 155 
CYS   C    C  N N 156 
CYS   O    O  N N 157 
CYS   CB   C  N N 158 
CYS   SG   S  N N 159 
CYS   OXT  O  N N 160 
CYS   H    H  N N 161 
CYS   H2   H  N N 162 
CYS   HA   H  N N 163 
CYS   HB2  H  N N 164 
CYS   HB3  H  N N 165 
CYS   HG   H  N N 166 
CYS   HXT  H  N N 167 
GLN   N    N  N N 168 
GLN   CA   C  N S 169 
GLN   C    C  N N 170 
GLN   O    O  N N 171 
GLN   CB   C  N N 172 
GLN   CG   C  N N 173 
GLN   CD   C  N N 174 
GLN   OE1  O  N N 175 
GLN   NE2  N  N N 176 
GLN   OXT  O  N N 177 
GLN   H    H  N N 178 
GLN   H2   H  N N 179 
GLN   HA   H  N N 180 
GLN   HB2  H  N N 181 
GLN   HB3  H  N N 182 
GLN   HG2  H  N N 183 
GLN   HG3  H  N N 184 
GLN   HE21 H  N N 185 
GLN   HE22 H  N N 186 
GLN   HXT  H  N N 187 
GLU   N    N  N N 188 
GLU   CA   C  N S 189 
GLU   C    C  N N 190 
GLU   O    O  N N 191 
GLU   CB   C  N N 192 
GLU   CG   C  N N 193 
GLU   CD   C  N N 194 
GLU   OE1  O  N N 195 
GLU   OE2  O  N N 196 
GLU   OXT  O  N N 197 
GLU   H    H  N N 198 
GLU   H2   H  N N 199 
GLU   HA   H  N N 200 
GLU   HB2  H  N N 201 
GLU   HB3  H  N N 202 
GLU   HG2  H  N N 203 
GLU   HG3  H  N N 204 
GLU   HE2  H  N N 205 
GLU   HXT  H  N N 206 
GLY   N    N  N N 207 
GLY   CA   C  N N 208 
GLY   C    C  N N 209 
GLY   O    O  N N 210 
GLY   OXT  O  N N 211 
GLY   H    H  N N 212 
GLY   H2   H  N N 213 
GLY   HA2  H  N N 214 
GLY   HA3  H  N N 215 
GLY   HXT  H  N N 216 
HIS   N    N  N N 217 
HIS   CA   C  N S 218 
HIS   C    C  N N 219 
HIS   O    O  N N 220 
HIS   CB   C  N N 221 
HIS   CG   C  Y N 222 
HIS   ND1  N  Y N 223 
HIS   CD2  C  Y N 224 
HIS   CE1  C  Y N 225 
HIS   NE2  N  Y N 226 
HIS   OXT  O  N N 227 
HIS   H    H  N N 228 
HIS   H2   H  N N 229 
HIS   HA   H  N N 230 
HIS   HB2  H  N N 231 
HIS   HB3  H  N N 232 
HIS   HD1  H  N N 233 
HIS   HD2  H  N N 234 
HIS   HE1  H  N N 235 
HIS   HE2  H  N N 236 
HIS   HXT  H  N N 237 
HOH   O    O  N N 238 
HOH   H1   H  N N 239 
HOH   H2   H  N N 240 
ILE   N    N  N N 241 
ILE   CA   C  N S 242 
ILE   C    C  N N 243 
ILE   O    O  N N 244 
ILE   CB   C  N S 245 
ILE   CG1  C  N N 246 
ILE   CG2  C  N N 247 
ILE   CD1  C  N N 248 
ILE   OXT  O  N N 249 
ILE   H    H  N N 250 
ILE   H2   H  N N 251 
ILE   HA   H  N N 252 
ILE   HB   H  N N 253 
ILE   HG12 H  N N 254 
ILE   HG13 H  N N 255 
ILE   HG21 H  N N 256 
ILE   HG22 H  N N 257 
ILE   HG23 H  N N 258 
ILE   HD11 H  N N 259 
ILE   HD12 H  N N 260 
ILE   HD13 H  N N 261 
ILE   HXT  H  N N 262 
LEU   N    N  N N 263 
LEU   CA   C  N S 264 
LEU   C    C  N N 265 
LEU   O    O  N N 266 
LEU   CB   C  N N 267 
LEU   CG   C  N N 268 
LEU   CD1  C  N N 269 
LEU   CD2  C  N N 270 
LEU   OXT  O  N N 271 
LEU   H    H  N N 272 
LEU   H2   H  N N 273 
LEU   HA   H  N N 274 
LEU   HB2  H  N N 275 
LEU   HB3  H  N N 276 
LEU   HG   H  N N 277 
LEU   HD11 H  N N 278 
LEU   HD12 H  N N 279 
LEU   HD13 H  N N 280 
LEU   HD21 H  N N 281 
LEU   HD22 H  N N 282 
LEU   HD23 H  N N 283 
LEU   HXT  H  N N 284 
LYS   N    N  N N 285 
LYS   CA   C  N S 286 
LYS   C    C  N N 287 
LYS   O    O  N N 288 
LYS   CB   C  N N 289 
LYS   CG   C  N N 290 
LYS   CD   C  N N 291 
LYS   CE   C  N N 292 
LYS   NZ   N  N N 293 
LYS   OXT  O  N N 294 
LYS   H    H  N N 295 
LYS   H2   H  N N 296 
LYS   HA   H  N N 297 
LYS   HB2  H  N N 298 
LYS   HB3  H  N N 299 
LYS   HG2  H  N N 300 
LYS   HG3  H  N N 301 
LYS   HD2  H  N N 302 
LYS   HD3  H  N N 303 
LYS   HE2  H  N N 304 
LYS   HE3  H  N N 305 
LYS   HZ1  H  N N 306 
LYS   HZ2  H  N N 307 
LYS   HZ3  H  N N 308 
LYS   HXT  H  N N 309 
MET   N    N  N N 310 
MET   CA   C  N S 311 
MET   C    C  N N 312 
MET   O    O  N N 313 
MET   CB   C  N N 314 
MET   CG   C  N N 315 
MET   SD   S  N N 316 
MET   CE   C  N N 317 
MET   OXT  O  N N 318 
MET   H    H  N N 319 
MET   H2   H  N N 320 
MET   HA   H  N N 321 
MET   HB2  H  N N 322 
MET   HB3  H  N N 323 
MET   HG2  H  N N 324 
MET   HG3  H  N N 325 
MET   HE1  H  N N 326 
MET   HE2  H  N N 327 
MET   HE3  H  N N 328 
MET   HXT  H  N N 329 
PHE   N    N  N N 330 
PHE   CA   C  N S 331 
PHE   C    C  N N 332 
PHE   O    O  N N 333 
PHE   CB   C  N N 334 
PHE   CG   C  Y N 335 
PHE   CD1  C  Y N 336 
PHE   CD2  C  Y N 337 
PHE   CE1  C  Y N 338 
PHE   CE2  C  Y N 339 
PHE   CZ   C  Y N 340 
PHE   OXT  O  N N 341 
PHE   H    H  N N 342 
PHE   H2   H  N N 343 
PHE   HA   H  N N 344 
PHE   HB2  H  N N 345 
PHE   HB3  H  N N 346 
PHE   HD1  H  N N 347 
PHE   HD2  H  N N 348 
PHE   HE1  H  N N 349 
PHE   HE2  H  N N 350 
PHE   HZ   H  N N 351 
PHE   HXT  H  N N 352 
PRO   N    N  N N 353 
PRO   CA   C  N S 354 
PRO   C    C  N N 355 
PRO   O    O  N N 356 
PRO   CB   C  N N 357 
PRO   CG   C  N N 358 
PRO   CD   C  N N 359 
PRO   OXT  O  N N 360 
PRO   H    H  N N 361 
PRO   HA   H  N N 362 
PRO   HB2  H  N N 363 
PRO   HB3  H  N N 364 
PRO   HG2  H  N N 365 
PRO   HG3  H  N N 366 
PRO   HD2  H  N N 367 
PRO   HD3  H  N N 368 
PRO   HXT  H  N N 369 
SER   N    N  N N 370 
SER   CA   C  N S 371 
SER   C    C  N N 372 
SER   O    O  N N 373 
SER   CB   C  N N 374 
SER   OG   O  N N 375 
SER   OXT  O  N N 376 
SER   H    H  N N 377 
SER   H2   H  N N 378 
SER   HA   H  N N 379 
SER   HB2  H  N N 380 
SER   HB3  H  N N 381 
SER   HG   H  N N 382 
SER   HXT  H  N N 383 
THR   N    N  N N 384 
THR   CA   C  N S 385 
THR   C    C  N N 386 
THR   O    O  N N 387 
THR   CB   C  N R 388 
THR   OG1  O  N N 389 
THR   CG2  C  N N 390 
THR   OXT  O  N N 391 
THR   H    H  N N 392 
THR   H2   H  N N 393 
THR   HA   H  N N 394 
THR   HB   H  N N 395 
THR   HG1  H  N N 396 
THR   HG21 H  N N 397 
THR   HG22 H  N N 398 
THR   HG23 H  N N 399 
THR   HXT  H  N N 400 
TRP   N    N  N N 401 
TRP   CA   C  N S 402 
TRP   C    C  N N 403 
TRP   O    O  N N 404 
TRP   CB   C  N N 405 
TRP   CG   C  Y N 406 
TRP   CD1  C  Y N 407 
TRP   CD2  C  Y N 408 
TRP   NE1  N  Y N 409 
TRP   CE2  C  Y N 410 
TRP   CE3  C  Y N 411 
TRP   CZ2  C  Y N 412 
TRP   CZ3  C  Y N 413 
TRP   CH2  C  Y N 414 
TRP   OXT  O  N N 415 
TRP   H    H  N N 416 
TRP   H2   H  N N 417 
TRP   HA   H  N N 418 
TRP   HB2  H  N N 419 
TRP   HB3  H  N N 420 
TRP   HD1  H  N N 421 
TRP   HE1  H  N N 422 
TRP   HE3  H  N N 423 
TRP   HZ2  H  N N 424 
TRP   HZ3  H  N N 425 
TRP   HH2  H  N N 426 
TRP   HXT  H  N N 427 
TYR   N    N  N N 428 
TYR   CA   C  N S 429 
TYR   C    C  N N 430 
TYR   O    O  N N 431 
TYR   CB   C  N N 432 
TYR   CG   C  Y N 433 
TYR   CD1  C  Y N 434 
TYR   CD2  C  Y N 435 
TYR   CE1  C  Y N 436 
TYR   CE2  C  Y N 437 
TYR   CZ   C  Y N 438 
TYR   OH   O  N N 439 
TYR   OXT  O  N N 440 
TYR   H    H  N N 441 
TYR   H2   H  N N 442 
TYR   HA   H  N N 443 
TYR   HB2  H  N N 444 
TYR   HB3  H  N N 445 
TYR   HD1  H  N N 446 
TYR   HD2  H  N N 447 
TYR   HE1  H  N N 448 
TYR   HE2  H  N N 449 
TYR   HH   H  N N 450 
TYR   HXT  H  N N 451 
VAL   N    N  N N 452 
VAL   CA   C  N S 453 
VAL   C    C  N N 454 
VAL   O    O  N N 455 
VAL   CB   C  N N 456 
VAL   CG1  C  N N 457 
VAL   CG2  C  N N 458 
VAL   OXT  O  N N 459 
VAL   H    H  N N 460 
VAL   H2   H  N N 461 
VAL   HA   H  N N 462 
VAL   HB   H  N N 463 
VAL   HG11 H  N N 464 
VAL   HG12 H  N N 465 
VAL   HG13 H  N N 466 
VAL   HG21 H  N N 467 
VAL   HG22 H  N N 468 
VAL   HG23 H  N N 469 
VAL   HXT  H  N N 470 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1L7Z C01  C02  doub Y N 1   
A1L7Z C01  C06  sing Y N 2   
A1L7Z C02  C03  sing Y N 3   
A1L7Z C02  O17  sing N N 4   
A1L7Z C03  C04  doub Y N 5   
A1L7Z C03  C31  sing N N 6   
A1L7Z C04  C05  sing Y N 7   
A1L7Z C05  C06  doub Y N 8   
A1L7Z C05  SI07 sing N N 9   
A1L7Z SI07 C08  sing N N 10  
A1L7Z SI07 C14  sing N N 11  
A1L7Z SI07 C15  sing N N 12  
A1L7Z C08  C09  doub Y N 13  
A1L7Z C08  C13  sing Y N 14  
A1L7Z C09  C10  sing Y N 15  
A1L7Z C10  C11  doub Y N 16  
A1L7Z C10  C32  sing N N 17  
A1L7Z C11  C12  sing Y N 18  
A1L7Z C11  O16  sing N N 19  
A1L7Z C12  C13  doub Y N 20  
A1L7Z O16  C23  sing N N 21  
A1L7Z O17  C18  sing N N 22  
A1L7Z C18  C19  sing N N 23  
A1L7Z C19  C20  sing N N 24  
A1L7Z C19  O34  sing N N 25  
A1L7Z C20  C21  sing N N 26  
A1L7Z C21  C22  sing N N 27  
A1L7Z C22  O30  doub N N 28  
A1L7Z C22  O33  sing N N 29  
A1L7Z C23  C24  sing N N 30  
A1L7Z C24  C25  sing N N 31  
A1L7Z C24  C26  sing N N 32  
A1L7Z C24  O29  sing N N 33  
A1L7Z C25  C27  sing N N 34  
A1L7Z C26  C28  sing N N 35  
A1L7Z C31  C36  sing N N 36  
A1L7Z C32  C35  sing N N 37  
A1L7Z C13  H131 sing N N 38  
A1L7Z C15  H153 sing N N 39  
A1L7Z C15  H151 sing N N 40  
A1L7Z C15  H152 sing N N 41  
A1L7Z C20  H201 sing N N 42  
A1L7Z C20  H202 sing N N 43  
A1L7Z C21  H211 sing N N 44  
A1L7Z C21  H212 sing N N 45  
A1L7Z C26  H262 sing N N 46  
A1L7Z C26  H261 sing N N 47  
A1L7Z C28  H283 sing N N 48  
A1L7Z C28  H282 sing N N 49  
A1L7Z C28  H281 sing N N 50  
A1L7Z C01  H011 sing N N 51  
A1L7Z C04  H041 sing N N 52  
A1L7Z C06  H061 sing N N 53  
A1L7Z C09  H091 sing N N 54  
A1L7Z C12  H121 sing N N 55  
A1L7Z C14  H141 sing N N 56  
A1L7Z C14  H143 sing N N 57  
A1L7Z C14  H142 sing N N 58  
A1L7Z C18  H182 sing N N 59  
A1L7Z C18  H181 sing N N 60  
A1L7Z C19  H191 sing N N 61  
A1L7Z C23  H232 sing N N 62  
A1L7Z C23  H231 sing N N 63  
A1L7Z C25  H252 sing N N 64  
A1L7Z C25  H251 sing N N 65  
A1L7Z C27  H272 sing N N 66  
A1L7Z C27  H273 sing N N 67  
A1L7Z C27  H271 sing N N 68  
A1L7Z C31  H312 sing N N 69  
A1L7Z C31  H311 sing N N 70  
A1L7Z C32  H321 sing N N 71  
A1L7Z C32  H322 sing N N 72  
A1L7Z C35  H351 sing N N 73  
A1L7Z C35  H352 sing N N 74  
A1L7Z C35  H353 sing N N 75  
A1L7Z C36  H363 sing N N 76  
A1L7Z C36  H362 sing N N 77  
A1L7Z C36  H361 sing N N 78  
A1L7Z O29  H291 sing N N 79  
A1L7Z O33  H1   sing N N 80  
A1L7Z O34  H341 sing N N 81  
ALA   N    CA   sing N N 82  
ALA   N    H    sing N N 83  
ALA   N    H2   sing N N 84  
ALA   CA   C    sing N N 85  
ALA   CA   CB   sing N N 86  
ALA   CA   HA   sing N N 87  
ALA   C    O    doub N N 88  
ALA   C    OXT  sing N N 89  
ALA   CB   HB1  sing N N 90  
ALA   CB   HB2  sing N N 91  
ALA   CB   HB3  sing N N 92  
ALA   OXT  HXT  sing N N 93  
ARG   N    CA   sing N N 94  
ARG   N    H    sing N N 95  
ARG   N    H2   sing N N 96  
ARG   CA   C    sing N N 97  
ARG   CA   CB   sing N N 98  
ARG   CA   HA   sing N N 99  
ARG   C    O    doub N N 100 
ARG   C    OXT  sing N N 101 
ARG   CB   CG   sing N N 102 
ARG   CB   HB2  sing N N 103 
ARG   CB   HB3  sing N N 104 
ARG   CG   CD   sing N N 105 
ARG   CG   HG2  sing N N 106 
ARG   CG   HG3  sing N N 107 
ARG   CD   NE   sing N N 108 
ARG   CD   HD2  sing N N 109 
ARG   CD   HD3  sing N N 110 
ARG   NE   CZ   sing N N 111 
ARG   NE   HE   sing N N 112 
ARG   CZ   NH1  sing N N 113 
ARG   CZ   NH2  doub N N 114 
ARG   NH1  HH11 sing N N 115 
ARG   NH1  HH12 sing N N 116 
ARG   NH2  HH21 sing N N 117 
ARG   NH2  HH22 sing N N 118 
ARG   OXT  HXT  sing N N 119 
ASN   N    CA   sing N N 120 
ASN   N    H    sing N N 121 
ASN   N    H2   sing N N 122 
ASN   CA   C    sing N N 123 
ASN   CA   CB   sing N N 124 
ASN   CA   HA   sing N N 125 
ASN   C    O    doub N N 126 
ASN   C    OXT  sing N N 127 
ASN   CB   CG   sing N N 128 
ASN   CB   HB2  sing N N 129 
ASN   CB   HB3  sing N N 130 
ASN   CG   OD1  doub N N 131 
ASN   CG   ND2  sing N N 132 
ASN   ND2  HD21 sing N N 133 
ASN   ND2  HD22 sing N N 134 
ASN   OXT  HXT  sing N N 135 
ASP   N    CA   sing N N 136 
ASP   N    H    sing N N 137 
ASP   N    H2   sing N N 138 
ASP   CA   C    sing N N 139 
ASP   CA   CB   sing N N 140 
ASP   CA   HA   sing N N 141 
ASP   C    O    doub N N 142 
ASP   C    OXT  sing N N 143 
ASP   CB   CG   sing N N 144 
ASP   CB   HB2  sing N N 145 
ASP   CB   HB3  sing N N 146 
ASP   CG   OD1  doub N N 147 
ASP   CG   OD2  sing N N 148 
ASP   OD2  HD2  sing N N 149 
ASP   OXT  HXT  sing N N 150 
CYS   N    CA   sing N N 151 
CYS   N    H    sing N N 152 
CYS   N    H2   sing N N 153 
CYS   CA   C    sing N N 154 
CYS   CA   CB   sing N N 155 
CYS   CA   HA   sing N N 156 
CYS   C    O    doub N N 157 
CYS   C    OXT  sing N N 158 
CYS   CB   SG   sing N N 159 
CYS   CB   HB2  sing N N 160 
CYS   CB   HB3  sing N N 161 
CYS   SG   HG   sing N N 162 
CYS   OXT  HXT  sing N N 163 
GLN   N    CA   sing N N 164 
GLN   N    H    sing N N 165 
GLN   N    H2   sing N N 166 
GLN   CA   C    sing N N 167 
GLN   CA   CB   sing N N 168 
GLN   CA   HA   sing N N 169 
GLN   C    O    doub N N 170 
GLN   C    OXT  sing N N 171 
GLN   CB   CG   sing N N 172 
GLN   CB   HB2  sing N N 173 
GLN   CB   HB3  sing N N 174 
GLN   CG   CD   sing N N 175 
GLN   CG   HG2  sing N N 176 
GLN   CG   HG3  sing N N 177 
GLN   CD   OE1  doub N N 178 
GLN   CD   NE2  sing N N 179 
GLN   NE2  HE21 sing N N 180 
GLN   NE2  HE22 sing N N 181 
GLN   OXT  HXT  sing N N 182 
GLU   N    CA   sing N N 183 
GLU   N    H    sing N N 184 
GLU   N    H2   sing N N 185 
GLU   CA   C    sing N N 186 
GLU   CA   CB   sing N N 187 
GLU   CA   HA   sing N N 188 
GLU   C    O    doub N N 189 
GLU   C    OXT  sing N N 190 
GLU   CB   CG   sing N N 191 
GLU   CB   HB2  sing N N 192 
GLU   CB   HB3  sing N N 193 
GLU   CG   CD   sing N N 194 
GLU   CG   HG2  sing N N 195 
GLU   CG   HG3  sing N N 196 
GLU   CD   OE1  doub N N 197 
GLU   CD   OE2  sing N N 198 
GLU   OE2  HE2  sing N N 199 
GLU   OXT  HXT  sing N N 200 
GLY   N    CA   sing N N 201 
GLY   N    H    sing N N 202 
GLY   N    H2   sing N N 203 
GLY   CA   C    sing N N 204 
GLY   CA   HA2  sing N N 205 
GLY   CA   HA3  sing N N 206 
GLY   C    O    doub N N 207 
GLY   C    OXT  sing N N 208 
GLY   OXT  HXT  sing N N 209 
HIS   N    CA   sing N N 210 
HIS   N    H    sing N N 211 
HIS   N    H2   sing N N 212 
HIS   CA   C    sing N N 213 
HIS   CA   CB   sing N N 214 
HIS   CA   HA   sing N N 215 
HIS   C    O    doub N N 216 
HIS   C    OXT  sing N N 217 
HIS   CB   CG   sing N N 218 
HIS   CB   HB2  sing N N 219 
HIS   CB   HB3  sing N N 220 
HIS   CG   ND1  sing Y N 221 
HIS   CG   CD2  doub Y N 222 
HIS   ND1  CE1  doub Y N 223 
HIS   ND1  HD1  sing N N 224 
HIS   CD2  NE2  sing Y N 225 
HIS   CD2  HD2  sing N N 226 
HIS   CE1  NE2  sing Y N 227 
HIS   CE1  HE1  sing N N 228 
HIS   NE2  HE2  sing N N 229 
HIS   OXT  HXT  sing N N 230 
HOH   O    H1   sing N N 231 
HOH   O    H2   sing N N 232 
ILE   N    CA   sing N N 233 
ILE   N    H    sing N N 234 
ILE   N    H2   sing N N 235 
ILE   CA   C    sing N N 236 
ILE   CA   CB   sing N N 237 
ILE   CA   HA   sing N N 238 
ILE   C    O    doub N N 239 
ILE   C    OXT  sing N N 240 
ILE   CB   CG1  sing N N 241 
ILE   CB   CG2  sing N N 242 
ILE   CB   HB   sing N N 243 
ILE   CG1  CD1  sing N N 244 
ILE   CG1  HG12 sing N N 245 
ILE   CG1  HG13 sing N N 246 
ILE   CG2  HG21 sing N N 247 
ILE   CG2  HG22 sing N N 248 
ILE   CG2  HG23 sing N N 249 
ILE   CD1  HD11 sing N N 250 
ILE   CD1  HD12 sing N N 251 
ILE   CD1  HD13 sing N N 252 
ILE   OXT  HXT  sing N N 253 
LEU   N    CA   sing N N 254 
LEU   N    H    sing N N 255 
LEU   N    H2   sing N N 256 
LEU   CA   C    sing N N 257 
LEU   CA   CB   sing N N 258 
LEU   CA   HA   sing N N 259 
LEU   C    O    doub N N 260 
LEU   C    OXT  sing N N 261 
LEU   CB   CG   sing N N 262 
LEU   CB   HB2  sing N N 263 
LEU   CB   HB3  sing N N 264 
LEU   CG   CD1  sing N N 265 
LEU   CG   CD2  sing N N 266 
LEU   CG   HG   sing N N 267 
LEU   CD1  HD11 sing N N 268 
LEU   CD1  HD12 sing N N 269 
LEU   CD1  HD13 sing N N 270 
LEU   CD2  HD21 sing N N 271 
LEU   CD2  HD22 sing N N 272 
LEU   CD2  HD23 sing N N 273 
LEU   OXT  HXT  sing N N 274 
LYS   N    CA   sing N N 275 
LYS   N    H    sing N N 276 
LYS   N    H2   sing N N 277 
LYS   CA   C    sing N N 278 
LYS   CA   CB   sing N N 279 
LYS   CA   HA   sing N N 280 
LYS   C    O    doub N N 281 
LYS   C    OXT  sing N N 282 
LYS   CB   CG   sing N N 283 
LYS   CB   HB2  sing N N 284 
LYS   CB   HB3  sing N N 285 
LYS   CG   CD   sing N N 286 
LYS   CG   HG2  sing N N 287 
LYS   CG   HG3  sing N N 288 
LYS   CD   CE   sing N N 289 
LYS   CD   HD2  sing N N 290 
LYS   CD   HD3  sing N N 291 
LYS   CE   NZ   sing N N 292 
LYS   CE   HE2  sing N N 293 
LYS   CE   HE3  sing N N 294 
LYS   NZ   HZ1  sing N N 295 
LYS   NZ   HZ2  sing N N 296 
LYS   NZ   HZ3  sing N N 297 
LYS   OXT  HXT  sing N N 298 
MET   N    CA   sing N N 299 
MET   N    H    sing N N 300 
MET   N    H2   sing N N 301 
MET   CA   C    sing N N 302 
MET   CA   CB   sing N N 303 
MET   CA   HA   sing N N 304 
MET   C    O    doub N N 305 
MET   C    OXT  sing N N 306 
MET   CB   CG   sing N N 307 
MET   CB   HB2  sing N N 308 
MET   CB   HB3  sing N N 309 
MET   CG   SD   sing N N 310 
MET   CG   HG2  sing N N 311 
MET   CG   HG3  sing N N 312 
MET   SD   CE   sing N N 313 
MET   CE   HE1  sing N N 314 
MET   CE   HE2  sing N N 315 
MET   CE   HE3  sing N N 316 
MET   OXT  HXT  sing N N 317 
PHE   N    CA   sing N N 318 
PHE   N    H    sing N N 319 
PHE   N    H2   sing N N 320 
PHE   CA   C    sing N N 321 
PHE   CA   CB   sing N N 322 
PHE   CA   HA   sing N N 323 
PHE   C    O    doub N N 324 
PHE   C    OXT  sing N N 325 
PHE   CB   CG   sing N N 326 
PHE   CB   HB2  sing N N 327 
PHE   CB   HB3  sing N N 328 
PHE   CG   CD1  doub Y N 329 
PHE   CG   CD2  sing Y N 330 
PHE   CD1  CE1  sing Y N 331 
PHE   CD1  HD1  sing N N 332 
PHE   CD2  CE2  doub Y N 333 
PHE   CD2  HD2  sing N N 334 
PHE   CE1  CZ   doub Y N 335 
PHE   CE1  HE1  sing N N 336 
PHE   CE2  CZ   sing Y N 337 
PHE   CE2  HE2  sing N N 338 
PHE   CZ   HZ   sing N N 339 
PHE   OXT  HXT  sing N N 340 
PRO   N    CA   sing N N 341 
PRO   N    CD   sing N N 342 
PRO   N    H    sing N N 343 
PRO   CA   C    sing N N 344 
PRO   CA   CB   sing N N 345 
PRO   CA   HA   sing N N 346 
PRO   C    O    doub N N 347 
PRO   C    OXT  sing N N 348 
PRO   CB   CG   sing N N 349 
PRO   CB   HB2  sing N N 350 
PRO   CB   HB3  sing N N 351 
PRO   CG   CD   sing N N 352 
PRO   CG   HG2  sing N N 353 
PRO   CG   HG3  sing N N 354 
PRO   CD   HD2  sing N N 355 
PRO   CD   HD3  sing N N 356 
PRO   OXT  HXT  sing N N 357 
SER   N    CA   sing N N 358 
SER   N    H    sing N N 359 
SER   N    H2   sing N N 360 
SER   CA   C    sing N N 361 
SER   CA   CB   sing N N 362 
SER   CA   HA   sing N N 363 
SER   C    O    doub N N 364 
SER   C    OXT  sing N N 365 
SER   CB   OG   sing N N 366 
SER   CB   HB2  sing N N 367 
SER   CB   HB3  sing N N 368 
SER   OG   HG   sing N N 369 
SER   OXT  HXT  sing N N 370 
THR   N    CA   sing N N 371 
THR   N    H    sing N N 372 
THR   N    H2   sing N N 373 
THR   CA   C    sing N N 374 
THR   CA   CB   sing N N 375 
THR   CA   HA   sing N N 376 
THR   C    O    doub N N 377 
THR   C    OXT  sing N N 378 
THR   CB   OG1  sing N N 379 
THR   CB   CG2  sing N N 380 
THR   CB   HB   sing N N 381 
THR   OG1  HG1  sing N N 382 
THR   CG2  HG21 sing N N 383 
THR   CG2  HG22 sing N N 384 
THR   CG2  HG23 sing N N 385 
THR   OXT  HXT  sing N N 386 
TRP   N    CA   sing N N 387 
TRP   N    H    sing N N 388 
TRP   N    H2   sing N N 389 
TRP   CA   C    sing N N 390 
TRP   CA   CB   sing N N 391 
TRP   CA   HA   sing N N 392 
TRP   C    O    doub N N 393 
TRP   C    OXT  sing N N 394 
TRP   CB   CG   sing N N 395 
TRP   CB   HB2  sing N N 396 
TRP   CB   HB3  sing N N 397 
TRP   CG   CD1  doub Y N 398 
TRP   CG   CD2  sing Y N 399 
TRP   CD1  NE1  sing Y N 400 
TRP   CD1  HD1  sing N N 401 
TRP   CD2  CE2  doub Y N 402 
TRP   CD2  CE3  sing Y N 403 
TRP   NE1  CE2  sing Y N 404 
TRP   NE1  HE1  sing N N 405 
TRP   CE2  CZ2  sing Y N 406 
TRP   CE3  CZ3  doub Y N 407 
TRP   CE3  HE3  sing N N 408 
TRP   CZ2  CH2  doub Y N 409 
TRP   CZ2  HZ2  sing N N 410 
TRP   CZ3  CH2  sing Y N 411 
TRP   CZ3  HZ3  sing N N 412 
TRP   CH2  HH2  sing N N 413 
TRP   OXT  HXT  sing N N 414 
TYR   N    CA   sing N N 415 
TYR   N    H    sing N N 416 
TYR   N    H2   sing N N 417 
TYR   CA   C    sing N N 418 
TYR   CA   CB   sing N N 419 
TYR   CA   HA   sing N N 420 
TYR   C    O    doub N N 421 
TYR   C    OXT  sing N N 422 
TYR   CB   CG   sing N N 423 
TYR   CB   HB2  sing N N 424 
TYR   CB   HB3  sing N N 425 
TYR   CG   CD1  doub Y N 426 
TYR   CG   CD2  sing Y N 427 
TYR   CD1  CE1  sing Y N 428 
TYR   CD1  HD1  sing N N 429 
TYR   CD2  CE2  doub Y N 430 
TYR   CD2  HD2  sing N N 431 
TYR   CE1  CZ   doub Y N 432 
TYR   CE1  HE1  sing N N 433 
TYR   CE2  CZ   sing Y N 434 
TYR   CE2  HE2  sing N N 435 
TYR   CZ   OH   sing N N 436 
TYR   OH   HH   sing N N 437 
TYR   OXT  HXT  sing N N 438 
VAL   N    CA   sing N N 439 
VAL   N    H    sing N N 440 
VAL   N    H2   sing N N 441 
VAL   CA   C    sing N N 442 
VAL   CA   CB   sing N N 443 
VAL   CA   HA   sing N N 444 
VAL   C    O    doub N N 445 
VAL   C    OXT  sing N N 446 
VAL   CB   CG1  sing N N 447 
VAL   CB   CG2  sing N N 448 
VAL   CB   HB   sing N N 449 
VAL   CG1  HG11 sing N N 450 
VAL   CG1  HG12 sing N N 451 
VAL   CG1  HG13 sing N N 452 
VAL   CG2  HG21 sing N N 453 
VAL   CG2  HG22 sing N N 454 
VAL   CG2  HG23 sing N N 455 
VAL   OXT  HXT  sing N N 456 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   2ZLC 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9M12 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.021791 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.001837 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.022232 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.007797 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
N  
O  
S  
SI 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N    . LYS   A 1 18  ? 11.77200  -3.73300  -14.54200 1.000 56.45435  ?  123 LYS   A N    1 
ATOM   2    C  CA   . LYS   A 1 18  ? 11.92800  -2.43900  -15.23600 1.000 34.25842  ?  123 LYS   A CA   1 
ATOM   3    C  C    . LYS   A 1 18  ? 12.63700  -1.47500  -14.28000 1.000 29.25237  ?  123 LYS   A C    1 
ATOM   4    O  O    . LYS   A 1 18  ? 12.51900  -0.29400  -14.46500 1.000 30.46482  ?  123 LYS   A O    1 
ATOM   5    C  CB   . LYS   A 1 18  ? 10.56800  -1.95300  -15.74200 1.000 30.26469  ?  123 LYS   A CB   1 
ATOM   6    C  CG   . LYS   A 1 18  ? 9.54400   -3.03900  -16.01700 1.000 25.09331  ?  123 LYS   A CG   1 
ATOM   7    C  CD   . LYS   A 1 18  ? 8.15500   -2.45000  -16.11500 1.000 49.27757  ?  123 LYS   A CD   1 
ATOM   8    C  CE   . LYS   A 1 18  ? 7.48100   -2.78500  -17.42400 1.000 49.73628  ?  123 LYS   A CE   1 
ATOM   9    N  NZ   . LYS   A 1 18  ? 8.44200   -2.71100  -18.54800 1.000 51.02761  ?  123 LYS   A NZ   1 
ATOM   10   N  N    . LEU   A 1 19  ? 13.32200  -2.01100  -13.27800 1.000 23.88131  ?  124 LEU   A N    1 
ATOM   11   C  CA   . LEU   A 1 19  ? 14.08700  -1.19200  -12.35000 1.000 21.05575  ?  124 LEU   A CA   1 
ATOM   12   C  C    . LEU   A 1 19  ? 15.34000  -0.66700  -13.03800 1.000 25.12491  ?  124 LEU   A C    1 
ATOM   13   O  O    . LEU   A 1 19  ? 16.06700  -1.42500  -13.68900 1.000 25.68470  ?  124 LEU   A O    1 
ATOM   14   C  CB   . LEU   A 1 19  ? 14.47500  -2.00700  -11.11800 1.000 21.80605  ?  124 LEU   A CB   1 
ATOM   15   C  CG   . LEU   A 1 19  ? 13.38300  -2.49900  -10.17100 1.000 26.09578  ?  124 LEU   A CG   1 
ATOM   16   C  CD1  . LEU   A 1 19  ? 13.89900  -3.68600  -9.38000  1.000 26.80711  ?  124 LEU   A CD1  1 
ATOM   17   C  CD2  . LEU   A 1 19  ? 12.95200  -1.38500  -9.23200  1.000 21.41128  ?  124 LEU   A CD2  1 
ATOM   18   N  N    . SER   A 1 20  ? 15.59800  0.62700   -12.89100 1.000 26.12305  ?  125 SER   A N    1 
ATOM   19   C  CA   . SER   A 1 20  ? 16.85000  1.17600   -13.38100 1.000 22.24767  ?  125 SER   A CA   1 
ATOM   20   C  C    . SER   A 1 20  ? 18.01900  0.61300   -12.57300 1.000 26.48248  ?  125 SER   A C    1 
ATOM   21   O  O    . SER   A 1 20  ? 17.84300  0.00600   -11.51400 1.000 19.43660  ?  125 SER   A O    1 
ATOM   22   C  CB   . SER   A 1 20  ? 16.83500  2.70100   -13.29800 1.000 23.31949  ?  125 SER   A CB   1 
ATOM   23   O  OG   . SER   A 1 20  ? 16.83300  3.12800   -11.94600 1.000 20.70648  ?  125 SER   A OG   1 
ATOM   24   N  N    . GLU   A 1 21  ? 19.23100  0.81200   -13.09500 1.000 21.64509  ?  126 GLU   A N    1 
ATOM   25   C  CA   . GLU   A 1 21  ? 20.42200  0.42800   -12.34500 1.000 22.53348  ?  126 GLU   A CA   1 
ATOM   26   C  C    . GLU   A 1 21  ? 20.47300  1.13300   -10.99700 1.000 17.64402  ?  126 GLU   A C    1 
ATOM   27   O  O    . GLU   A 1 21  ? 20.82000  0.52000   -9.98000  1.000 21.39120  ?  126 GLU   A O    1 
ATOM   28   C  CB   . GLU   A 1 21  ? 21.68100  0.74600   -13.15100 1.000 27.45417  ?  126 GLU   A CB   1 
ATOM   29   C  CG   . GLU   A 1 21  ? 22.73500  -0.33300  -13.09100 1.000 45.11037  ?  126 GLU   A CG   1 
ATOM   30   C  CD   . GLU   A 1 21  ? 24.03200  0.10200   -13.73500 1.000 53.38634  ?  126 GLU   A CD   1 
ATOM   31   O  OE1  . GLU   A 1 21  ? 23.98600  0.64200   -14.86100 1.000 43.33127  ?  126 GLU   A OE1  1 
ATOM   32   O  OE2  . GLU   A 1 21  ? 25.09600  -0.10000  -13.11700 1.000 44.26628  ?  126 GLU   A OE2  1 
ATOM   33   N  N    . GLU   A 1 22  ? 20.12700  2.42300   -10.97200 1.000 21.69163  ?  127 GLU   A N    1 
ATOM   34   C  CA   . GLU   A 1 22  ? 20.12800  3.17900   -9.72300  1.000 20.31833  ?  127 GLU   A CA   1 
ATOM   35   C  C    . GLU   A 1 22  ? 19.12100  2.61300   -8.72700  1.000 17.64239  ?  127 GLU   A C    1 
ATOM   36   O  O    . GLU   A 1 22  ? 19.40300  2.53800   -7.52600  1.000 14.04108  ?  127 GLU   A O    1 
ATOM   37   C  CB   . GLU   A 1 22  ? 19.82600  4.65100   -10.00500 1.000 22.67077  ?  127 GLU   A CB   1 
ATOM   38   C  CG   . GLU   A 1 22  ? 19.86700  5.54500   -8.77700  1.000 38.12437  ?  127 GLU   A CG   1 
ATOM   39   C  CD   . GLU   A 1 22  ? 19.32100  6.93400   -9.04900  1.000 51.36479  ?  127 GLU   A CD   1 
ATOM   40   O  OE1  . GLU   A 1 22  ? 18.69800  7.13100   -10.11500 1.000 53.00059  ?  127 GLU   A OE1  1 
ATOM   41   O  OE2  . GLU   A 1 22  ? 19.51100  7.82700   -8.19600  1.000 48.85300  ?  127 GLU   A OE2  1 
ATOM   42   N  N    . GLN   A 1 23  ? 17.93200  2.23000   -9.20400  1.000 17.31787  ?  128 GLN   A N    1 
ATOM   43   C  CA   . GLN   A 1 23  ? 16.93400  1.64700   -8.31400  1.000 14.16850  ?  128 GLN   A CA   1 
ATOM   44   C  C    . GLN   A 1 23  ? 17.39200  0.29300   -7.78500  1.000 19.69911  ?  128 GLN   A C    1 
ATOM   45   O  O    . GLN   A 1 23  ? 17.21500  -0.00500  -6.59900  1.000 14.73385  ?  128 GLN   A O    1 
ATOM   46   C  CB   . GLN   A 1 23  ? 15.58800  1.52200   -9.03900  1.000 16.83622  ?  128 GLN   A CB   1 
ATOM   47   C  CG   . GLN   A 1 23  ? 14.89400  2.86600   -9.26500  1.000 16.95827  ?  128 GLN   A CG   1 
ATOM   48   C  CD   . GLN   A 1 23  ? 13.74900  2.79300   -10.25500 1.000 19.97920  ?  128 GLN   A CD   1 
ATOM   49   O  OE1  . GLN   A 1 23  ? 13.67600  1.87900   -11.07400 1.000 17.29847  ?  128 GLN   A OE1  1 
ATOM   50   N  NE2  . GLN   A 1 23  ? 12.84700  3.76500   -10.18600 1.000 23.28192  ?  128 GLN   A NE2  1 
ATOM   51   N  N    . GLN   A 1 24  ? 17.98100  -0.54000  -8.64900  1.000 18.33308  ?  129 GLN   A N    1 
ATOM   52   C  CA   . GLN   A 1 24  ? 18.54300  -1.81000  -8.19500  1.000 20.19500  ?  129 GLN   A CA   1 
ATOM   53   C  C    . GLN   A 1 24  ? 19.64500  -1.58300  -7.16800  1.000 13.90978  ?  129 GLN   A C    1 
ATOM   54   O  O    . GLN   A 1 24  ? 19.74900  -2.31800  -6.17600  1.000 14.17142  ?  129 GLN   A O    1 
ATOM   55   C  CB   . GLN   A 1 24  ? 19.09100  -2.59300  -9.39000  1.000 17.44816  ?  129 GLN   A CB   1 
ATOM   56   C  CG   . GLN   A 1 24  ? 18.05600  -2.95400  -10.44700 1.000 21.24045  ?  129 GLN   A CG   1 
ATOM   57   C  CD   . GLN   A 1 24  ? 18.68100  -3.60900  -11.67000 1.000 33.08873  ?  129 GLN   A CD   1 
ATOM   58   O  OE1  . GLN   A 1 24  ? 19.47800  -4.54000  -11.55200 1.000 25.30020  ?  129 GLN   A OE1  1 
ATOM   59   N  NE2  . GLN   A 1 24  ? 18.32700  -3.11700  -12.85100 1.000 33.06566  ?  129 GLN   A NE2  1 
ATOM   60   N  N    . HIS   A 1 25  ? 20.48600  -0.57600  -7.40800  1.000 13.11232  ?  130 HIS   A N    1 
ATOM   61   C  CA   . HIS   A 1 25  ? 21.55100  -0.21100  -6.47900  1.000 13.40686  ?  130 HIS   A CA   1 
ATOM   62   C  C    . HIS   A 1 25  ? 20.98800  0.14500   -5.10600  1.000 14.22855  ?  130 HIS   A C    1 
ATOM   63   O  O    . HIS   A 1 25  ? 21.49800  -0.30800  -4.07600  1.000 14.55302  ?  130 HIS   A O    1 
ATOM   64   C  CB   . HIS   A 1 25  ? 22.33700  0.95500   -7.08400  1.000 21.59946  ?  130 HIS   A CB   1 
ATOM   65   C  CG   . HIS   A 1 25  ? 23.30600  1.61100   -6.15300  1.000 29.65005  ?  130 HIS   A CG   1 
ATOM   66   N  ND1  . HIS   A 1 25  ? 24.53200  1.06400   -5.84400  1.000 41.33109  ?  130 HIS   A ND1  1 
ATOM   67   C  CD2  . HIS   A 1 25  ? 23.24900  2.79700   -5.50300  1.000 37.65319  ?  130 HIS   A CD2  1 
ATOM   68   C  CE1  . HIS   A 1 25  ? 25.17900  1.87500   -5.02600  1.000 36.49518  ?  130 HIS   A CE1  1 
ATOM   69   N  NE2  . HIS   A 1 25  ? 24.42200  2.93500   -4.80500  1.000 35.70125  ?  130 HIS   A NE2  1 
ATOM   70   N  N    . ILE   A 1 26  ? 19.93100  0.96000   -5.08100  1.000 13.67393  ?  131 ILE   A N    1 
ATOM   71   C  CA   . ILE   A 1 26  ? 19.27700  1.32300   -3.82500  1.000 14.00635  ?  131 ILE   A CA   1 
ATOM   72   C  C    . ILE   A 1 26  ? 18.77500  0.07800   -3.10600  1.000 14.30216  ?  131 ILE   A C    1 
ATOM   73   O  O    . ILE   A 1 26  ? 18.98400  -0.09400  -1.89700  1.000 14.50876  ?  131 ILE   A O    1 
ATOM   74   C  CB   . ILE   A 1 26  ? 18.13200  2.31600   -4.09400  1.000 14.20275  ?  131 ILE   A CB   1 
ATOM   75   C  CG1  . ILE   A 1 26  ? 18.69400  3.66700   -4.53300  1.000 13.52101  ?  131 ILE   A CG1  1 
ATOM   76   C  CG2  . ILE   A 1 26  ? 17.20500  2.43800   -2.87300  1.000 11.51713  ?  131 ILE   A CG2  1 
ATOM   77   C  CD1  . ILE   A 1 26  ? 17.65800  4.58900   -5.13800  1.000 13.51510  ?  131 ILE   A CD1  1 
ATOM   78   N  N    . ILE   A 1 27  ? 18.09300  -0.80700  -3.83600  1.000 12.42991  ?  132 ILE   A N    1 
ATOM   79   C  CA   . ILE   A 1 27  ? 17.55400  -2.01500  -3.21300  1.000 15.74466  ?  132 ILE   A CA   1 
ATOM   80   C  C    . ILE   A 1 27  ? 18.68300  -2.89300  -2.68400  1.000 17.90442  ?  132 ILE   A C    1 
ATOM   81   O  O    . ILE   A 1 27  ? 18.60600  -3.42900  -1.57100  1.000 13.11108  ?  132 ILE   A O    1 
ATOM   82   C  CB   . ILE   A 1 27  ? 16.65700  -2.77600  -4.20800  1.000 16.15110  ?  132 ILE   A CB   1 
ATOM   83   C  CG1  . ILE   A 1 27  ? 15.41000  -1.95300  -4.54300  1.000 19.92886  ?  132 ILE   A CG1  1 
ATOM   84   C  CG2  . ILE   A 1 27  ? 16.26100  -4.12900  -3.64300  1.000 17.88200  ?  132 ILE   A CG2  1 
ATOM   85   C  CD1  . ILE   A 1 27  ? 14.50600  -2.60900  -5.57500  1.000 21.29985  ?  132 ILE   A CD1  1 
ATOM   86   N  N    . ALA   A 1 28  ? 19.75500  -3.04500  -3.46500  1.000 11.64916  ?  133 ALA   A N    1 
ATOM   87   C  CA   . ALA   A 1 28  ? 20.88300  -3.87000  -3.03500  1.000 13.26637  ?  133 ALA   A CA   1 
ATOM   88   C  C    . ALA   A 1 28  ? 21.50200  -3.35200  -1.74000  1.000 12.64992  ?  133 ALA   A C    1 
ATOM   89   O  O    . ALA   A 1 28  ? 21.86300  -4.13800  -0.85400  1.000 15.39290  ?  133 ALA   A O    1 
ATOM   90   C  CB   . ALA   A 1 28  ? 21.93500  -3.92300  -4.14000  1.000 16.50474  ?  133 ALA   A CB   1 
ATOM   91   N  N    . ILE   A 1 29  ? 21.65200  -2.03300  -1.62000  1.000 12.93145  ?  134 ILE   A N    1 
ATOM   92   C  CA   . ILE   A 1 29  ? 22.21800  -1.45500  -0.40300  1.000 12.94781  ?  134 ILE   A CA   1 
ATOM   93   C  C    . ILE   A 1 29  ? 21.30600  -1.71800  0.79000   1.000 14.80684  ?  134 ILE   A C    1 
ATOM   94   O  O    . ILE   A 1 29  ? 21.77400  -2.05300  1.88500   1.000 13.28666  ?  134 ILE   A O    1 
ATOM   95   C  CB   . ILE   A 1 29  ? 22.47300  0.05000   -0.60100  1.000 16.48688  ?  134 ILE   A CB   1 
ATOM   96   C  CG1  . ILE   A 1 29  ? 23.64900  0.27000   -1.55500  1.000 14.84694  ?  134 ILE   A CG1  1 
ATOM   97   C  CG2  . ILE   A 1 29  ? 22.74000  0.73700   0.72800   1.000 18.30060  ?  134 ILE   A CG2  1 
ATOM   98   C  CD1  . ILE   A 1 29  ? 23.86100  1.72200   -1.91200  1.000 20.35811  ?  134 ILE   A CD1  1 
ATOM   99   N  N    . LEU   A 1 30  ? 19.99200  -1.57100  0.60000   1.000 14.49166  ?  135 LEU   A N    1 
ATOM   100  C  CA   . LEU   A 1 30  ? 19.06400  -1.73000  1.71800   1.000 12.28494  ?  135 LEU   A CA   1 
ATOM   101  C  C    . LEU   A 1 30  ? 18.95500  -3.18800  2.14800   1.000 16.15474  ?  135 LEU   A C    1 
ATOM   102  O  O    . LEU   A 1 30  ? 18.88900  -3.48100  3.34600   1.000 14.09212  ?  135 LEU   A O    1 
ATOM   103  C  CB   . LEU   A 1 30  ? 17.68800  -1.17500  1.34700   1.000 16.74949  ?  135 LEU   A CB   1 
ATOM   104  C  CG   . LEU   A 1 30  ? 17.60600  0.33400   1.09200   1.000 16.37771  ?  135 LEU   A CG   1 
ATOM   105  C  CD1  . LEU   A 1 30  ? 16.17900  0.74500   0.73700   1.000 16.54108  ?  135 LEU   A CD1  1 
ATOM   106  C  CD2  . LEU   A 1 30  ? 18.12100  1.12100   2.29500   1.000 15.86927  ?  135 LEU   A CD2  1 
ATOM   107  N  N    . LEU   A 1 31  ? 18.92800  -4.11600  1.18700   1.000 16.62592  ?  136 LEU   A N    1 
ATOM   108  C  CA   . LEU   A 1 31  ? 18.93300  -5.53400  1.53700   1.000 15.25270  ?  136 LEU   A CA   1 
ATOM   109  C  C    . LEU   A 1 31  ? 20.18600  -5.90000  2.31900   1.000 15.38700  ?  136 LEU   A C    1 
ATOM   110  O  O    . LEU   A 1 31  ? 20.11400  -6.63200  3.31400   1.000 17.32970  ?  136 LEU   A O    1 
ATOM   111  C  CB   . LEU   A 1 31  ? 18.82300  -6.39300  0.27600   1.000 14.66254  ?  136 LEU   A CB   1 
ATOM   112  C  CG   . LEU   A 1 31  ? 17.45400  -6.44500  -0.41000  1.000 19.00084  ?  136 LEU   A CG   1 
ATOM   113  C  CD1  . LEU   A 1 31  ? 17.53700  -7.23500  -1.71100  1.000 13.97530  ?  136 LEU   A CD1  1 
ATOM   114  C  CD2  . LEU   A 1 31  ? 16.40900  -7.04800  0.52000   1.000 17.71624  ?  136 LEU   A CD2  1 
ATOM   115  N  N    . ASP   A 1 32  ? 21.34600  -5.40400  1.88000   1.000 15.72096  ?  137 ASP   A N    1 
ATOM   116  C  CA   . ASP   A 1 32  ? 22.58400  -5.63500  2.61900   1.000 18.80950  ?  137 ASP   A CA   1 
ATOM   117  C  C    . ASP   A 1 32  ? 22.49600  -5.05500  4.02400   1.000 21.30453  ?  137 ASP   A C    1 
ATOM   118  O  O    . ASP   A 1 32  ? 22.87000  -5.71100  5.00200   1.000 18.29521  ?  137 ASP   A O    1 
ATOM   119  C  CB   . ASP   A 1 32  ? 23.76800  -5.03000  1.86500   1.000 15.48651  ?  137 ASP   A CB   1 
ATOM   120  C  CG   . ASP   A 1 32  ? 25.04900  -5.05300  2.68000   1.000 27.71549  ?  137 ASP   A CG   1 
ATOM   121  O  OD1  . ASP   A 1 32  ? 25.33500  -4.06400  3.39000   1.000 23.11540  ?  137 ASP   A OD1  1 
ATOM   122  O  OD2  . ASP   A 1 32  ? 25.76600  -6.06700  2.61700   1.000 20.15906  ?  137 ASP   A OD2  1 
ATOM   123  N  N    . ALA   A 1 33  ? 21.99700  -3.82100  4.14200   1.000 15.01656  ?  138 ALA   A N    1 
ATOM   124  C  CA   . ALA   A 1 33  ? 21.90100  -3.17700  5.44900   1.000 12.22307  ?  138 ALA   A CA   1 
ATOM   125  C  C    . ALA   A 1 33  ? 20.97400  -3.94500  6.37800   1.000 16.18042  ?  138 ALA   A C    1 
ATOM   126  O  O    . ALA   A 1 33  ? 21.26900  -4.10800  7.56900   1.000 16.48490  ?  138 ALA   A O    1 
ATOM   127  C  CB   . ALA   A 1 33  ? 21.41200  -1.73900  5.29100   1.000 14.64652  ?  138 ALA   A CB   1 
ATOM   128  N  N    . HIS   A 1 34  ? 19.84300  -4.41600  5.85100   1.000 15.67423  ?  139 HIS   A N    1 
ATOM   129  C  CA   . HIS   A 1 34  ? 18.90300  -5.18100  6.66300   1.000 17.53890  ?  139 HIS   A CA   1 
ATOM   130  C  C    . HIS   A 1 34  ? 19.51300  -6.50400  7.10900   1.000 28.28652  ?  139 HIS   A C    1 
ATOM   131  O  O    . HIS   A 1 34  ? 19.42200  -6.87700  8.28500   1.000 20.33521  ?  139 HIS   A O    1 
ATOM   132  C  CB   . HIS   A 1 34  ? 17.61700  -5.41800  5.87700   1.000 17.31259  ?  139 HIS   A CB   1 
ATOM   133  C  CG   . HIS   A 1 34  ? 16.56800  -6.16600  6.63800   1.000 22.95579  ?  139 HIS   A CG   1 
ATOM   134  N  ND1  . HIS   A 1 34  ? 16.17900  -5.81500  7.91300   1.000 19.02840  ?  139 HIS   A ND1  1 
ATOM   135  C  CD2  . HIS   A 1 34  ? 15.82100  -7.24300  6.29900   1.000 21.90763  ?  139 HIS   A CD2  1 
ATOM   136  C  CE1  . HIS   A 1 34  ? 15.23900  -6.64600  8.32800   1.000 26.73697  ?  139 HIS   A CE1  1 
ATOM   137  N  NE2  . HIS   A 1 34  ? 15.00400  -7.52200  7.36800   1.000 24.01398  ?  139 HIS   A NE2  1 
ATOM   138  N  N    . HIS   A 1 35  ? 20.14100  -7.22900  6.18000   1.000 18.21461  ?  140 HIS   A N    1 
ATOM   139  C  CA   . HIS   A 1 35  ? 20.72600  -8.52300  6.52800   1.000 18.27113  ?  140 HIS   A CA   1 
ATOM   140  C  C    . HIS   A 1 35  ? 21.84200  -8.37800  7.55400   1.000 21.68437  ?  140 HIS   A C    1 
ATOM   141  O  O    . HIS   A 1 35  ? 22.09000  -9.30600  8.33100   1.000 30.47084  ?  140 HIS   A O    1 
ATOM   142  C  CB   . HIS   A 1 35  ? 21.23800  -9.22300  5.27000   1.000 22.39321  ?  140 HIS   A CB   1 
ATOM   143  C  CG   . HIS   A 1 35  ? 20.15200  -9.55800  4.29700   1.000 19.53886  ?  140 HIS   A CG   1 
ATOM   144  N  ND1  . HIS   A 1 35  ? 20.39500  -9.83700  2.97000   1.000 24.12630  ?  140 HIS   A ND1  1 
ATOM   145  C  CD2  . HIS   A 1 35  ? 18.81000  -9.65400  4.46200   1.000 29.64828  ?  140 HIS   A CD2  1 
ATOM   146  C  CE1  . HIS   A 1 35  ? 19.25100  -10.09400 2.36000   1.000 21.97928  ?  140 HIS   A CE1  1 
ATOM   147  N  NE2  . HIS   A 1 35  ? 18.27400  -9.98800  3.24200   1.000 21.37824  ?  140 HIS   A NE2  1 
ATOM   148  N  N    . LYS   A 1 36  ? 22.52000  -7.22400  7.57800   1.000 21.90988  ?  141 LYS   A N    1 
ATOM   149  C  CA   . LYS   A 1 36  ? 23.55700  -6.99800  8.57900   1.000 25.79024  ?  141 LYS   A CA   1 
ATOM   150  C  C    . LYS   A 1 36  ? 22.97400  -6.65800  9.94500   1.000 34.32154  ?  141 LYS   A C    1 
ATOM   151  O  O    . LYS   A 1 36  ? 23.63500  -6.88100  10.96400  1.000 33.33649  ?  141 LYS   A O    1 
ATOM   152  C  CB   . LYS   A 1 36  ? 24.50200  -5.87800  8.14700   1.000 25.56425  ?  141 LYS   A CB   1 
ATOM   153  C  CG   . LYS   A 1 36  ? 25.36500  -6.19100  6.94500   1.000 48.11156  ?  141 LYS   A CG   1 
ATOM   154  C  CD   . LYS   A 1 36  ? 26.69900  -5.50300  7.06000   1.000 54.70679  ?  141 LYS   A CD   1 
ATOM   155  C  CE   . LYS   A 1 36  ? 26.51500  -3.99800  7.18500   1.000 59.07587  ?  141 LYS   A CE   1 
ATOM   156  N  NZ   . LYS   A 1 36  ? 27.48800  -3.25600  6.34200   1.000 66.58969  ?  141 LYS   A NZ   1 
ATOM   157  N  N    . THR   A 1 37  ? 21.75800  -6.11600  9.99600   1.000 25.82301  ?  142 THR   A N    1 
ATOM   158  C  CA   . THR   A 1 37  ? 21.18900  -5.62100  11.24700  1.000 34.27380  ?  142 THR   A CA   1 
ATOM   159  C  C    . THR   A 1 37  ? 19.99900  -6.44000  11.73200  1.000 39.13239  ?  142 THR   A C    1 
ATOM   160  O  O    . THR   A 1 37  ? 19.26400  -5.98300  12.61400  1.000 50.49666  ?  142 THR   A O    1 
ATOM   161  C  CB   . THR   A 1 37  ? 20.77900  -4.15000  11.11000  1.000 19.98626  ?  142 THR   A CB   1 
ATOM   162  O  OG1  . THR   A 1 37  ? 19.91000  -3.99500  9.98400   1.000 22.88379  ?  142 THR   A OG1  1 
ATOM   163  C  CG2  . THR   A 1 37  ? 22.00300  -3.27000  10.91700  1.000 32.87849  ?  142 THR   A CG2  1 
ATOM   164  N  N    . TYR   A 1 38  ? 19.79100  -7.63600  11.18900  1.000 46.90912  ?  143 TYR   A N    1 
ATOM   165  C  CA   . TYR   A 1 38  ? 18.70100  -8.50100  11.62900  1.000 57.89764  ?  143 TYR   A CA   1 
ATOM   166  C  C    . TYR   A 1 38  ? 19.20800  -9.93300  11.67200  1.000 63.85059  ?  143 TYR   A C    1 
ATOM   167  O  O    . TYR   A 1 38  ? 19.61900  -10.47900 10.64300  1.000 46.44290  ?  143 TYR   A O    1 
ATOM   168  C  CB   . TYR   A 1 38  ? 17.48400  -8.37900  10.70300  1.000 45.62087  ?  143 TYR   A CB   1 
ATOM   169  C  CG   . TYR   A 1 38  ? 16.22100  -9.02800  11.23900  1.000 55.80994  ?  143 TYR   A CG   1 
ATOM   170  C  CD1  . TYR   A 1 38  ? 16.06800  -10.41100 11.23400  1.000 55.10415  ?  143 TYR   A CD1  1 
ATOM   171  C  CD2  . TYR   A 1 38  ? 15.18300  -8.25800  11.75000  1.000 48.49251  ?  143 TYR   A CD2  1 
ATOM   172  C  CE1  . TYR   A 1 38  ? 14.92000  -11.00700 11.72300  1.000 60.86488  ?  143 TYR   A CE1  1 
ATOM   173  C  CE2  . TYR   A 1 38  ? 14.02800  -8.84700  12.24100  1.000 52.21693  ?  143 TYR   A CE2  1 
ATOM   174  C  CZ   . TYR   A 1 38  ? 13.90500  -10.22100 12.22500  1.000 46.41707  ?  143 TYR   A CZ   1 
ATOM   175  O  OH   . TYR   A 1 38  ? 12.76300  -10.81400 12.70900  1.000 44.24896  ?  143 TYR   A OH   1 
ATOM   176  N  N    . ASP   A 1 39  ? 19.16900  -10.53600 12.86000  1.000 67.01785  ?  144 ASP   A N    1 
ATOM   177  C  CA   . ASP   A 1 39  ? 19.59100  -11.92000 13.04900  1.000 63.90625  ?  144 ASP   A CA   1 
ATOM   178  C  C    . ASP   A 1 39  ? 18.36200  -12.78800 13.27900  1.000 72.16483  ?  144 ASP   A C    1 
ATOM   179  O  O    . ASP   A 1 39  ? 17.74200  -12.70300 14.35200  1.000 62.61188  ?  144 ASP   A O    1 
ATOM   180  C  CB   . ASP   A 1 39  ? 20.56100  -12.03100 14.22900  1.000 60.88846  ?  144 ASP   A CB   1 
ATOM   181  C  CG   . ASP   A 1 39  ? 21.16100  -13.42000 14.37600  1.000 60.15600  ?  144 ASP   A CG   1 
ATOM   182  O  OD1  . ASP   A 1 39  ? 20.40300  -14.40900 14.44700  1.000 53.56637  ?  144 ASP   A OD1  1 
ATOM   183  O  OD2  . ASP   A 1 39  ? 22.40500  -13.52200 14.41400  1.000 72.75073  ?  144 ASP   A OD2  1 
ATOM   184  N  N    . PRO   A 1 40  ? 17.97200  -13.63000 12.31800  1.000 71.95521  ?  145 PRO   A N    1 
ATOM   185  C  CA   . PRO   A 1 40  ? 16.73400  -14.40600 12.45700  1.000 63.91500  ?  145 PRO   A CA   1 
ATOM   186  C  C    . PRO   A 1 40  ? 16.81600  -15.57600 13.42600  1.000 61.06909  ?  145 PRO   A C    1 
ATOM   187  O  O    . PRO   A 1 40  ? 15.79200  -16.22800 13.65900  1.000 51.34451  ?  145 PRO   A O    1 
ATOM   188  C  CB   . PRO   A 1 40  ? 16.48600  -14.90000 11.02300  1.000 63.15017  ?  145 PRO   A CB   1 
ATOM   189  C  CG   . PRO   A 1 40  ? 17.85400  -15.00300 10.44000  1.000 53.21607  ?  145 PRO   A CG   1 
ATOM   190  C  CD   . PRO   A 1 40  ? 18.59500  -13.81800 10.99600  1.000 75.81477  ?  145 PRO   A CD   1 
ATOM   191  N  N    . THR   A 1 41  ? 17.98700  -15.87800 13.98900  1.000 56.20889  ?  146 THR   A N    1 
ATOM   192  C  CA   . THR   A 1 41  ? 18.06800  -16.92600 15.00000  1.000 66.13154  ?  146 THR   A CA   1 
ATOM   193  C  C    . THR   A 1 41  ? 17.70200  -16.42900 16.39000  1.000 63.49382  ?  146 THR   A C    1 
ATOM   194  O  O    . THR   A 1 41  ? 17.48300  -17.25600 17.28300  1.000 62.39680  ?  146 THR   A O    1 
ATOM   195  C  CB   . THR   A 1 41  ? 19.47300  -17.53400 15.04300  1.000 54.52619  ?  146 THR   A CB   1 
ATOM   196  O  OG1  . THR   A 1 41  ? 20.39600  -16.57500 15.57500  1.000 54.69395  ?  146 THR   A OG1  1 
ATOM   197  C  CG2  . THR   A 1 41  ? 19.91800  -17.95400 13.65100  1.000 61.28306  ?  146 THR   A CG2  1 
ATOM   198  N  N    . TYR   A 1 42  ? 17.63900  -15.10700 16.58600  1.000 56.55243  ?  147 TYR   A N    1 
ATOM   199  C  CA   . TYR   A 1 42  ? 17.28500  -14.51000 17.87500  1.000 49.32255  ?  147 TYR   A CA   1 
ATOM   200  C  C    . TYR   A 1 42  ? 18.24900  -14.96200 18.96900  1.000 56.45414  ?  147 TYR   A C    1 
ATOM   201  O  O    . TYR   A 1 42  ? 17.85100  -15.21100 20.10700  1.000 50.94722  ?  147 TYR   A O    1 
ATOM   202  C  CB   . TYR   A 1 42  ? 15.84000  -14.83700 18.25600  1.000 41.90779  ?  147 TYR   A CB   1 
ATOM   203  C  CG   . TYR   A 1 42  ? 14.84000  -14.61600 17.14400  1.000 47.44681  ?  147 TYR   A CG   1 
ATOM   204  C  CD1  . TYR   A 1 42  ? 14.61800  -13.34500 16.61600  1.000 56.85546  ?  147 TYR   A CD1  1 
ATOM   205  C  CD2  . TYR   A 1 42  ? 14.15900  -15.68400 16.58400  1.000 60.00820  ?  147 TYR   A CD2  1 
ATOM   206  C  CE1  . TYR   A 1 42  ? 13.70400  -13.14900 15.59300  1.000 59.55213  ?  147 TYR   A CE1  1 
ATOM   207  C  CE2  . TYR   A 1 42  ? 13.25100  -15.50000 15.56500  1.000 56.97670  ?  147 TYR   A CE2  1 
ATOM   208  C  CZ   . TYR   A 1 42  ? 13.02700  -14.23300 15.07000  1.000 61.85624  ?  147 TYR   A CZ   1 
ATOM   209  O  OH   . TYR   A 1 42  ? 12.11800  -14.06600 14.05000  1.000 58.14479  ?  147 TYR   A OH   1 
ATOM   210  N  N    . ALA   A 1 43  ? 19.52900  -15.07600 18.61400  1.000 50.25261  ?  148 ALA   A N    1 
ATOM   211  C  CA   . ALA   A 1 43  ? 20.52100  -15.58500 19.55400  1.000 52.64559  ?  148 ALA   A CA   1 
ATOM   212  C  C    . ALA   A 1 43  ? 20.74700  -14.61600 20.70900  1.000 53.78671  ?  148 ALA   A C    1 
ATOM   213  O  O    . ALA   A 1 43  ? 20.90200  -15.03800 21.86000  1.000 49.97672  ?  148 ALA   A O    1 
ATOM   214  C  CB   . ALA   A 1 43  ? 21.83400  -15.86800 18.82300  1.000 47.79258  ?  148 ALA   A CB   1 
ATOM   215  N  N    . ASP   A 1 44  ? 20.76500  -13.31400 20.42500  1.000 43.51598  ?  149 ASP   A N    1 
ATOM   216  C  CA   . ASP   A 1 44  ? 21.07600  -12.33500 21.45900  1.000 49.97894  ?  149 ASP   A CA   1 
ATOM   217  C  C    . ASP   A 1 44  ? 19.96900  -12.18600 22.49500  1.000 39.49505  ?  149 ASP   A C    1 
ATOM   218  O  O    . ASP   A 1 44  ? 20.19700  -11.53800 23.52100  1.000 40.79239  ?  149 ASP   A O    1 
ATOM   219  C  CB   . ASP   A 1 44  ? 21.37200  -10.97600 20.82200  1.000 47.66311  ?  149 ASP   A CB   1 
ATOM   220  C  CG   . ASP   A 1 44  ? 22.49700  -11.04200 19.80700  1.000 64.21869  ?  149 ASP   A CG   1 
ATOM   221  O  OD1  . ASP   A 1 44  ? 23.49600  -11.74400 20.06900  1.000 61.64675  ?  149 ASP   A OD1  1 
ATOM   222  O  OD2  . ASP   A 1 44  ? 22.38400  -10.38800 18.74800  1.000 58.50777  ?  149 ASP   A OD2  1 
ATOM   223  N  N    . PHE   A 1 45  ? 18.79100  -12.77100 22.26400  1.000 30.99274  ?  150 PHE   A N    1 
ATOM   224  C  CA   . PHE   A 1 45  ? 17.69600  -12.63500 23.22100  1.000 42.02081  ?  150 PHE   A CA   1 
ATOM   225  C  C    . PHE   A 1 45  ? 18.02400  -13.28800 24.55700  1.000 43.59619  ?  150 PHE   A C    1 
ATOM   226  O  O    . PHE   A 1 45  ? 17.46600  -12.89400 25.58800  1.000 36.72503  ?  150 PHE   A O    1 
ATOM   227  C  CB   . PHE   A 1 45  ? 16.40700  -13.22700 22.64800  1.000 35.71478  ?  150 PHE   A CB   1 
ATOM   228  C  CG   . PHE   A 1 45  ? 15.73100  -12.35100 21.62600  1.000 42.91622  ?  150 PHE   A CG   1 
ATOM   229  C  CD1  . PHE   A 1 45  ? 16.47400  -11.60800 20.72000  1.000 34.91091  ?  150 PHE   A CD1  1 
ATOM   230  C  CD2  . PHE   A 1 45  ? 14.34800  -12.27700 21.57000  1.000 35.20217  ?  150 PHE   A CD2  1 
ATOM   231  C  CE1  . PHE   A 1 45  ? 15.85200  -10.80700 19.77800  1.000 40.18912  ?  150 PHE   A CE1  1 
ATOM   232  C  CE2  . PHE   A 1 45  ? 13.72000  -11.48000 20.63000  1.000 39.00838  ?  150 PHE   A CE2  1 
ATOM   233  C  CZ   . PHE   A 1 45  ? 14.47300  -10.74400 19.73300  1.000 38.28847  ?  150 PHE   A CZ   1 
ATOM   234  N  N    . ARG   A 1 46  ? 18.94300  -14.24800 24.55200  1.000 44.13983  ?  151 ARG   A N    1 
ATOM   235  C  CA   . ARG   A 1 46  ? 19.35400  -14.90500 25.81300  1.000 44.01702  ?  151 ARG   A CA   1 
ATOM   236  C  C    . ARG   A 1 46  ? 20.19300  -13.93500 26.65400  1.000 45.41678  ?  151 ARG   A C    1 
ATOM   237  O  O    . ARG   A 1 46  ? 20.46900  -14.27400 27.80200  1.000 39.01526  ?  151 ARG   A O    1 
ATOM   238  C  CB   . ARG   A 1 46  ? 20.15600  -16.18200 25.54100  1.000 53.15850  ?  151 ARG   A CB   1 
ATOM   239  C  CG   . ARG   A 1 46  ? 19.81700  -16.91100 24.24700  1.000 60.06810  ?  151 ARG   A CG   1 
ATOM   240  C  CD   . ARG   A 1 46  ? 20.69400  -18.13700 23.97700  1.000 70.31577  ?  151 ARG   A CD   1 
ATOM   241  N  NE   . ARG   A 1 46  ? 21.94200  -17.85000 23.27800  1.000 67.39448  ?  151 ARG   A NE   1 
ATOM   242  C  CZ   . ARG   A 1 46  ? 23.10800  -18.45800 23.47300  1.000 70.97743  ?  151 ARG   A CZ   1 
ATOM   243  N  NH1  . ARG   A 1 46  ? 24.15800  -18.09800 22.75900  1.000 70.52052  ?  151 ARG   A NH1  1 
ATOM   244  N  NH2  . ARG   A 1 46  ? 23.22700  -19.43600 24.34800  1.000 75.37233  ?  151 ARG   A NH2  1 
ATOM   245  N  N    . ASP   A 1 47  ? 20.62600  -12.80300 26.09400  1.000 32.61304  ?  152 ASP   A N    1 
ATOM   246  C  CA   . ASP   A 1 47  ? 21.44700  -11.83800 26.81300  1.000 29.84836  ?  152 ASP   A CA   1 
ATOM   247  C  C    . ASP   A 1 47  ? 20.62800  -10.77500 27.53200  1.000 27.88298  ?  152 ASP   A C    1 
ATOM   248  O  O    . ASP   A 1 47  ? 21.19400  -10.00500 28.31400  1.000 28.97177  ?  152 ASP   A O    1 
ATOM   249  C  CB   . ASP   A 1 47  ? 22.42200  -11.15300 25.85100  1.000 42.36869  ?  152 ASP   A CB   1 
ATOM   250  C  CG   . ASP   A 1 47  ? 23.31000  -12.14000 25.12200  1.000 55.76958  ?  152 ASP   A CG   1 
ATOM   251  O  OD1  . ASP   A 1 47  ? 23.57300  -13.22700 25.67800  1.000 50.87618  ?  152 ASP   A OD1  1 
ATOM   252  O  OD2  . ASP   A 1 47  ? 23.73800  -11.83000 23.98900  1.000 51.51286  ?  152 ASP   A OD2  1 
ATOM   253  N  N    . PHE   A 1 48  ? 19.32500  -10.70600 27.28200  1.000 25.14258  ?  153 PHE   A N    1 
ATOM   254  C  CA   . PHE   A 1 48  ? 18.48500  -9.72300  27.94300  1.000 24.26098  ?  153 PHE   A CA   1 
ATOM   255  C  C    . PHE   A 1 48  ? 18.19600  -10.16000 29.37600  1.000 25.94396  ?  153 PHE   A C    1 
ATOM   256  O  O    . PHE   A 1 48  ? 18.43200  -11.30800 29.76500  1.000 27.61635  ?  153 PHE   A O    1 
ATOM   257  C  CB   . PHE   A 1 48  ? 17.16600  -9.53400  27.18900  1.000 21.22773  ?  153 PHE   A CB   1 
ATOM   258  C  CG   . PHE   A 1 48  ? 17.32600  -9.22500  25.71900  1.000 17.18251  ?  153 PHE   A CG   1 
ATOM   259  C  CD1  . PHE   A 1 48  ? 16.29200  -9.49500  24.83400  1.000 24.52723  ?  153 PHE   A CD1  1 
ATOM   260  C  CD2  . PHE   A 1 48  ? 18.48700  -8.65000  25.22500  1.000 23.99516  ?  153 PHE   A CD2  1 
ATOM   261  C  CE1  . PHE   A 1 48  ? 16.41800  -9.21600  23.48300  1.000 28.50276  ?  153 PHE   A CE1  1 
ATOM   262  C  CE2  . PHE   A 1 48  ? 18.62100  -8.36900  23.87100  1.000 24.98540  ?  153 PHE   A CE2  1 
ATOM   263  C  CZ   . PHE   A 1 48  ? 17.58300  -8.65000  23.00300  1.000 24.59245  ?  153 PHE   A CZ   1 
ATOM   264  N  N    . ARG   A 1 49  ? 17.68000  -9.22800  30.16900  1.000 27.72931  ?  154 ARG   A N    1 
ATOM   265  C  CA   . ARG   A 1 49  ? 17.06000  -9.62200  31.42200  1.000 20.69679  ?  154 ARG   A CA   1 
ATOM   266  C  C    . ARG   A 1 49  ? 15.90900  -10.57900 31.11800  1.000 25.27537  ?  154 ARG   A C    1 
ATOM   267  O  O    . ARG   A 1 49  ? 15.17200  -10.37100 30.14700  1.000 29.93719  ?  154 ARG   A O    1 
ATOM   268  C  CB   . ARG   A 1 49  ? 16.56400  -8.39500  32.18800  1.000 23.82738  ?  154 ARG   A CB   1 
ATOM   269  C  CG   . ARG   A 1 49  ? 17.69400  -7.57500  32.80500  1.000 24.57183  ?  154 ARG   A CG   1 
ATOM   270  C  CD   . ARG   A 1 49  ? 17.21300  -6.23500  33.34600  1.000 26.01727  ?  154 ARG   A CD   1 
ATOM   271  N  NE   . ARG   A 1 49  ? 16.92000  -5.27700  32.28200  1.000 22.21896  ?  154 ARG   A NE   1 
ATOM   272  C  CZ   . ARG   A 1 49  ? 16.39700  -4.07300  32.49000  1.000 29.87585  ?  154 ARG   A CZ   1 
ATOM   273  N  NH1  . ARG   A 1 49  ? 16.11500  -3.67400  33.72500  1.000 26.58846  ?  154 ARG   A NH1  1 
ATOM   274  N  NH2  . ARG   A 1 49  ? 16.15700  -3.26600  31.46500  1.000 21.32450  ?  154 ARG   A NH2  1 
ATOM   275  N  N    . PRO   A 1 50  ? 15.74500  -11.65200 31.89600  1.000 27.60819  ?  155 PRO   A N    1 
ATOM   276  C  CA   . PRO   A 1 50  ? 14.83300  -12.71500 31.48400  1.000 31.55748  ?  155 PRO   A CA   1 
ATOM   277  C  C    . PRO   A 1 50  ? 13.38500  -12.25400 31.54800  1.000 29.49133  ?  155 PRO   A C    1 
ATOM   278  O  O    . PRO   A 1 50  ? 13.03000  -11.39100 32.36700  1.000 32.47101  ?  155 PRO   A O    1 
ATOM   279  C  CB   . PRO   A 1 50  ? 15.10600  -13.83500 32.50400  1.000 28.91181  ?  155 PRO   A CB   1 
ATOM   280  C  CG   . PRO   A 1 50  ? 16.42300  -13.49800 33.12300  1.000 42.99217  ?  155 PRO   A CG   1 
ATOM   281  C  CD   . PRO   A 1 50  ? 16.50400  -12.00700 33.10700  1.000 39.52090  ?  155 PRO   A CD   1 
ATOM   282  N  N    . PRO   A 1 51  ? 12.52100  -12.80000 30.69600  1.000 34.25403  ?  156 PRO   A N    1 
ATOM   283  C  CA   . PRO   A 1 51  ? 11.09000  -12.51700 30.83400  1.000 32.90754  ?  156 PRO   A CA   1 
ATOM   284  C  C    . PRO   A 1 51  ? 10.55700  -13.09700 32.13300  1.000 46.44889  ?  156 PRO   A C    1 
ATOM   285  O  O    . PRO   A 1 51  ? 10.99600  -14.15500 32.58900  1.000 34.89688  ?  156 PRO   A O    1 
ATOM   286  C  CB   . PRO   A 1 51  ? 10.46800  -13.20200 29.61200  1.000 36.46538  ?  156 PRO   A CB   1 
ATOM   287  C  CG   . PRO   A 1 51  ? 11.44000  -14.27200 29.24300  1.000 42.69248  ?  156 PRO   A CG   1 
ATOM   288  C  CD   . PRO   A 1 51  ? 12.80300  -13.75300 29.60900  1.000 32.27090  ?  156 PRO   A CD   1 
ATOM   289  N  N    . VAL   A 1 52  ? 9.45100   -12.53400 32.71100  1.000 42.72263  ?  157 VAL   A N    1 
ATOM   290  C  CA   . VAL   A 1 52  ? 8.86000   -13.10500 33.96000  1.000 55.75179  ?  157 VAL   A CA   1 
ATOM   291  C  C    . VAL   A 1 52  ? 7.33900   -13.00500 33.86300  1.000 58.13927  ?  157 VAL   A C    1 
ATOM   292  O  O    . VAL   A 1 52  ? 6.87100   -11.87700 33.77900  1.000 53.96573  ?  157 VAL   A O    1 
ATOM   293  C  CB   . VAL   A 1 52  ? 9.39800   -12.37500 35.20100  1.000 64.32026  ?  157 VAL   A CB   1 
ATOM   294  C  CG1  . VAL   A 1 52  ? 8.65400   -12.78100 36.46100  1.000 60.62090  ?  157 VAL   A CG1  1 
ATOM   295  C  CG2  . VAL   A 1 52  ? 10.90000  -12.57000 35.37200  1.000 52.66680  ?  157 VAL   A CG2  1 
ATOM   296  N  N    . ARG   A 1 53  ? 6.53400   -14.03100 33.78800  1.000 68.94809  ?  158 ARG   A N    1 
ATOM   297  C  CA   . ARG   A 1 53  ? 5.14200   -13.55500 33.64100  1.000 69.86562  ?  158 ARG   A CA   1 
ATOM   298  C  C    . ARG   A 1 53  ? 4.48200   -13.53300 35.02900  1.000 86.39689  ?  158 ARG   A C    1 
ATOM   299  O  O    . ARG   A 1 53  ? 4.01100   -14.61600 35.43100  1.000 85.41607  ?  158 ARG   A O    1 
ATOM   300  C  CB   . ARG   A 1 53  ? 4.44600   -14.34200 32.52800  1.000 67.27446  ?  158 ARG   A CB   1 
ATOM   301  C  CG   . ARG   A 1 53  ? 4.85400   -13.90400 31.12500  1.000 66.57029  ?  158 ARG   A CG   1 
ATOM   302  C  CD   . ARG   A 1 53  ? 5.46400   -14.95000 30.20400  1.000 57.62465  ?  158 ARG   A CD   1 
ATOM   303  N  NE   . ARG   A 1 53  ? 5.60300   -14.44800 28.84100  1.000 55.30324  ?  158 ARG   A NE   1 
ATOM   304  C  CZ   . ARG   A 1 53  ? 6.68400   -14.52800 28.06700  1.000 59.05737  ?  158 ARG   A CZ   1 
ATOM   305  N  NH1  . ARG   A 1 53  ? 7.79300   -15.09000 28.50100  1.000 44.57223  ?  158 ARG   A NH1  1 
ATOM   306  N  NH2  . ARG   A 1 53  ? 6.65300   -14.03300 26.84800  1.000 52.03402  ?  158 ARG   A NH2  1 
ATOM   307  N  N    . MET   A 1 54  ? 4.47700   -12.37700 35.73600  1.000 86.76034  ?  159 MET   A N    1 
ATOM   308  C  CA   . MET   A 1 54  ? 3.89600   -12.38800 37.07100  1.000 84.76146  ?  159 MET   A CA   1 
ATOM   309  C  C    . MET   A 1 54  ? 3.17800   -11.07900 37.38000  1.000 80.84898  ?  159 MET   A C    1 
ATOM   310  O  O    . MET   A 1 54  ? 3.80300   -10.02700 37.48800  1.000 79.27976  ?  159 MET   A O    1 
ATOM   311  C  CB   . MET   A 1 54  ? 4.97600   -12.66000 38.12100  1.000 89.81218  ?  159 MET   A CB   1 
ATOM   312  C  CG   . MET   A 1 54  ? 4.45900   -12.63500 39.54500  1.000 96.77605  ?  159 MET   A CG   1 
ATOM   313  S  SD   . MET   A 1 54  ? 5.77500   -12.29600 40.72700  1.000 102.86291 ?  159 MET   A SD   1 
ATOM   314  C  CE   . MET   A 1 54  ? 6.80000   -11.18000 39.78600  1.000 93.62096  ?  159 MET   A CE   1 
ATOM   315  N  N    A SER   A 1 66  ? 3.87100   -8.75200  40.85100  0.590 41.37604  ?  218 SER   A N    1 
ATOM   316  N  N    B SER   A 1 66  ? 3.86700   -8.74200  40.85200  0.410 41.41971  ?  218 SER   A N    1 
ATOM   317  C  CA   A SER   A 1 66  ? 4.60900   -7.50600  40.68800  0.590 40.37320  ?  218 SER   A CA   1 
ATOM   318  C  CA   B SER   A 1 66  ? 4.58100   -7.47600  40.74300  0.410 40.36753  ?  218 SER   A CA   1 
ATOM   319  C  C    A SER   A 1 66  ? 4.17300   -6.80900  39.40400  0.590 32.86237  ?  218 SER   A C    1 
ATOM   320  C  C    B SER   A 1 66  ? 4.23100   -6.79400  39.42400  0.410 32.96705  ?  218 SER   A C    1 
ATOM   321  O  O    A SER   A 1 66  ? 4.12300   -7.44900  38.34400  0.590 33.82967  ?  218 SER   A O    1 
ATOM   322  O  O    B SER   A 1 66  ? 4.30300   -7.42600  38.36500  0.410 34.39297  ?  218 SER   A O    1 
ATOM   323  C  CB   A SER   A 1 66  ? 6.11400   -7.77000  40.64500  0.590 39.69395  ?  218 SER   A CB   1 
ATOM   324  C  CB   B SER   A 1 66  ? 6.09000   -7.68700  40.84500  0.410 39.96053  ?  218 SER   A CB   1 
ATOM   325  O  OG   A SER   A 1 66  ? 6.63700   -8.00100  41.94000  0.590 37.87425  ?  218 SER   A OG   1 
ATOM   326  O  OG   B SER   A 1 66  ? 6.66200   -7.90600  39.57000  0.410 36.37513  ?  218 SER   A OG   1 
ATOM   327  N  N    . PRO   A 1 67  ? 3.83900   -5.52400  39.44900  1.000 30.27897  ?  219 PRO   A N    1 
ATOM   328  C  CA   . PRO   A 1 67  ? 3.51700   -4.81900  38.20500  1.000 31.48890  ?  219 PRO   A CA   1 
ATOM   329  C  C    . PRO   A 1 67  ? 4.74800   -4.64700  37.32600  1.000 32.60807  ?  219 PRO   A C    1 
ATOM   330  O  O    . PRO   A 1 67  ? 5.88100   -4.57200  37.80700  1.000 31.11609  ?  219 PRO   A O    1 
ATOM   331  C  CB   . PRO   A 1 67  ? 2.98200   -3.46300  38.68300  1.000 29.07453  ?  219 PRO   A CB   1 
ATOM   332  C  CG   . PRO   A 1 67  ? 3.36900   -3.34900  40.12200  1.000 40.14103  ?  219 PRO   A CG   1 
ATOM   333  C  CD   . PRO   A 1 67  ? 3.60900   -4.71400  40.65800  1.000 39.55473  ?  219 PRO   A CD   1 
ATOM   334  N  N    . LEU   A 1 68  ? 4.50400   -4.60200  36.01500  1.000 28.96604  ?  220 LEU   A N    1 
ATOM   335  C  CA   . LEU   A 1 68  ? 5.54500   -4.34400  35.01600  1.000 22.46348  ?  220 LEU   A CA   1 
ATOM   336  C  C    . LEU   A 1 68  ? 6.62400   -5.42200  35.02500  1.000 23.73648  ?  220 LEU   A C    1 
ATOM   337  O  O    . LEU   A 1 68  ? 7.81200   -5.13500  34.86200  1.000 25.17221  ?  220 LEU   A O    1 
ATOM   338  C  CB   . LEU   A 1 68  ? 6.16900   -2.96200  35.21000  1.000 29.23142  ?  220 LEU   A CB   1 
ATOM   339  C  CG   . LEU   A 1 68  ? 5.19300   -1.79100  35.24000  1.000 32.80343  ?  220 LEU   A CG   1 
ATOM   340  C  CD1  . LEU   A 1 68  ? 5.85200   -0.59200  35.85900  1.000 41.58500  ?  220 LEU   A CD1  1 
ATOM   341  C  CD2  . LEU   A 1 68  ? 4.76400   -1.47300  33.84700  1.000 37.23235  ?  220 LEU   A CD2  1 
ATOM   342  N  N    . SER   A 1 69  ? 6.21200   -6.67800  35.20400  1.000 23.17999  ?  221 SER   A N    1 
ATOM   343  C  CA   . SER   A 1 69  ? 7.18400   -7.76200  35.28600  1.000 28.35290  ?  221 SER   A CA   1 
ATOM   344  C  C    . SER   A 1 69  ? 7.87100   -8.03600  33.95300  1.000 24.34899  ?  221 SER   A C    1 
ATOM   345  O  O    . SER   A 1 69  ? 8.92900   -8.67300  33.93900  1.000 24.39448  ?  221 SER   A O    1 
ATOM   346  C  CB   . SER   A 1 69  ? 6.51200   -9.03600  35.79600  1.000 27.64059  ?  221 SER   A CB   1 
ATOM   347  O  OG   . SER   A 1 69  ? 5.44200   -9.41800  34.95300  1.000 28.60778  ?  221 SER   A OG   1 
ATOM   348  N  N    . MET   A 1 70  ? 7.30000   -7.57700  32.83900  1.000 19.56374  ?  222 MET   A N    1 
ATOM   349  C  CA   . MET   A 1 70  ? 7.90600   -7.76200  31.52400  1.000 23.35153  ?  222 MET   A CA   1 
ATOM   350  C  C    . MET   A 1 70  ? 8.60800   -6.51200  31.01100  1.000 32.88538  ?  222 MET   A C    1 
ATOM   351  O  O    . MET   A 1 70  ? 9.12500   -6.52300  29.88900  1.000 20.26829  ?  222 MET   A O    1 
ATOM   352  C  CB   . MET   A 1 70  ? 6.84900   -8.21100  30.51000  1.000 26.26628  ?  222 MET   A CB   1 
ATOM   353  C  CG   . MET   A 1 70  ? 6.43800   -9.67200  30.65700  1.000 26.63375  ?  222 MET   A CG   1 
ATOM   354  S  SD   . MET   A 1 70  ? 7.78700   -10.82100 30.31000  1.000 31.90080  ?  222 MET   A SD   1 
ATOM   355  C  CE   . MET   A 1 70  ? 7.74300   -10.87000 28.51900  1.000 39.47450  ?  222 MET   A CE   1 
ATOM   356  N  N    . LEU   A 1 71  ? 8.64400   -5.44200  31.80000  1.000 22.58242  ?  223 LEU   A N    1 
ATOM   357  C  CA   . LEU   A 1 71  ? 9.29500   -4.20700  31.37700  1.000 21.77278  ?  223 LEU   A CA   1 
ATOM   358  C  C    . LEU   A 1 71  ? 10.81300  -4.36200  31.26500  1.000 22.66691  ?  223 LEU   A C    1 
ATOM   359  O  O    . LEU   A 1 71  ? 11.39300  -3.85800  30.29700  1.000 21.18298  ?  223 LEU   A O    1 
ATOM   360  C  CB   . LEU   A 1 71  ? 8.94400   -3.05700  32.32600  1.000 23.10092  ?  223 LEU   A CB   1 
ATOM   361  C  CG   . LEU   A 1 71  ? 9.58500   -1.70100  32.01300  1.000 25.83903  ?  223 LEU   A CG   1 
ATOM   362  C  CD1  . LEU   A 1 71  ? 9.28000   -1.27300  30.58500  1.000 22.18776  ?  223 LEU   A CD1  1 
ATOM   363  C  CD2  . LEU   A 1 71  ? 9.12800   -0.64200  33.00600  1.000 23.84180  ?  223 LEU   A CD2  1 
ATOM   364  N  N    . PRO   A 1 72  ? 11.50200  -5.02200  32.21000  1.000 23.86862  ?  224 PRO   A N    1 
ATOM   365  C  CA   . PRO   A 1 72  ? 12.95600  -5.20200  32.02700  1.000 23.26448  ?  224 PRO   A CA   1 
ATOM   366  C  C    . PRO   A 1 72  ? 13.31900  -5.95100  30.75700  1.000 19.66359  ?  224 PRO   A C    1 
ATOM   367  O  O    . PRO   A 1 72  ? 14.22500  -5.52600  30.02800  1.000 20.81990  ?  224 PRO   A O    1 
ATOM   368  C  CB   . PRO   A 1 72  ? 13.37700  -5.97500  33.28500  1.000 18.68446  ?  224 PRO   A CB   1 
ATOM   369  C  CG   . PRO   A 1 72  ? 12.34500  -5.63600  34.29800  1.000 18.25940  ?  224 PRO   A CG   1 
ATOM   370  C  CD   . PRO   A 1 72  ? 11.06500  -5.48900  33.54200  1.000 22.02903  ?  224 PRO   A CD   1 
ATOM   371  N  N    . HIS   A 1 73  ? 12.64300  -7.06800  30.47800  1.000 19.32362  ?  225 HIS   A N    1 
ATOM   372  C  CA   . HIS   A 1 73  ? 12.95400  -7.84000  29.27900  1.000 20.64021  ?  225 HIS   A CA   1 
ATOM   373  C  C    . HIS   A 1 73  ? 12.60800  -7.05900  28.01800  1.000 21.49605  ?  225 HIS   A C    1 
ATOM   374  O  O    . HIS   A 1 73  ? 13.41500  -6.97600  27.08600  1.000 21.64469  ?  225 HIS   A O    1 
ATOM   375  C  CB   . HIS   A 1 73  ? 12.21000  -9.17600  29.30200  1.000 22.37327  ?  225 HIS   A CB   1 
ATOM   376  C  CG   . HIS   A 1 73  ? 12.53700  -10.06600 28.14300  1.000 20.08685  ?  225 HIS   A CG   1 
ATOM   377  N  ND1  . HIS   A 1 73  ? 13.74800  -10.71400 28.01900  1.000 19.94290  ?  225 HIS   A ND1  1 
ATOM   378  C  CD2  . HIS   A 1 73  ? 11.81500  -10.40700 27.04900  1.000 29.54933  ?  225 HIS   A CD2  1 
ATOM   379  C  CE1  . HIS   A 1 73  ? 13.75500  -11.42200 26.90400  1.000 25.00998  ?  225 HIS   A CE1  1 
ATOM   380  N  NE2  . HIS   A 1 73  ? 12.59300  -11.25300 26.29700  1.000 28.52831  ?  225 HIS   A NE2  1 
ATOM   381  N  N    . LEU   A 1 74  ? 11.41200  -6.46600  27.97700  1.000 18.07755  ?  226 LEU   A N    1 
ATOM   382  C  CA   . LEU   A 1 74  ? 10.98000  -5.77800  26.76700  1.000 17.30727  ?  226 LEU   A CA   1 
ATOM   383  C  C    . LEU   A 1 74  ? 11.71900  -4.46100  26.56500  1.000 23.16868  ?  226 LEU   A C    1 
ATOM   384  O  O    . LEU   A 1 74  ? 11.88000  -4.01700  25.42200  1.000 20.52961  ?  226 LEU   A O    1 
ATOM   385  C  CB   . LEU   A 1 74  ? 9.46700   -5.55700  26.80100  1.000 18.26507  ?  226 LEU   A CB   1 
ATOM   386  C  CG   . LEU   A 1 74  ? 8.65200   -6.84900  26.66300  1.000 22.06504  ?  226 LEU   A CG   1 
ATOM   387  C  CD1  . LEU   A 1 74  ? 7.16100   -6.55800  26.58600  1.000 27.61116  ?  226 LEU   A CD1  1 
ATOM   388  C  CD2  . LEU   A 1 74  ? 9.11100   -7.64200  25.44700  1.000 28.56689  ?  226 LEU   A CD2  1 
ATOM   389  N  N    . ALA   A 1 75  ? 12.17800  -3.82100  27.64700  1.000 16.50492  ?  227 ALA   A N    1 
ATOM   390  C  CA   . ALA   A 1 75  ? 13.04000  -2.65300  27.48000  1.000 15.29986  ?  227 ALA   A CA   1 
ATOM   391  C  C    . ALA   A 1 75  ? 14.37400  -3.04600  26.85800  1.000 16.74861  ?  227 ALA   A C    1 
ATOM   392  O  O    . ALA   A 1 75  ? 14.88900  -2.34600  25.97700  1.000 19.45916  ?  227 ALA   A O    1 
ATOM   393  C  CB   . ALA   A 1 75  ? 13.27000  -1.95100  28.81900  1.000 15.30066  ?  227 ALA   A CB   1 
ATOM   394  N  N    . ASP   A 1 76  ? 14.95100  -4.16300  27.31000  1.000 13.40339  ?  228 ASP   A N    1 
ATOM   395  C  CA   . ASP   A 1 76  ? 16.18500  -4.65500  26.70400  1.000 17.02366  ?  228 ASP   A CA   1 
ATOM   396  C  C    . ASP   A 1 76  ? 15.97500  -5.01300  25.23900  1.000 18.41247  ?  228 ASP   A C    1 
ATOM   397  O  O    . ASP   A 1 76  ? 16.85000  -4.76300  24.40000  1.000 22.07392  ?  228 ASP   A O    1 
ATOM   398  C  CB   . ASP   A 1 76  ? 16.71100  -5.86800  27.47000  1.000 15.29793  ?  228 ASP   A CB   1 
ATOM   399  C  CG   . ASP   A 1 76  ? 17.28500  -5.50300  28.82800  1.000 24.76919  ?  228 ASP   A CG   1 
ATOM   400  O  OD1  . ASP   A 1 76  ? 17.47900  -6.41500  29.65900  1.000 19.07445  ?  228 ASP   A OD1  1 
ATOM   401  O  OD2  . ASP   A 1 76  ? 17.55400  -4.30600  29.05800  1.000 20.83296  ?  228 ASP   A OD2  1 
ATOM   402  N  N    . LEU   A 1 77  ? 14.82400  -5.60900  24.91600  1.000 16.99322  ?  229 LEU   A N    1 
ATOM   403  C  CA   . LEU   A 1 77  ? 14.51800  -5.93900  23.52700  1.000 16.84311  ?  229 LEU   A CA   1 
ATOM   404  C  C    . LEU   A 1 77  ? 14.40400  -4.68000  22.67400  1.000 23.60313  ?  229 LEU   A C    1 
ATOM   405  O  O    . LEU   A 1 77  ? 14.95700  -4.60900  21.56900  1.000 18.68188  ?  229 LEU   A O    1 
ATOM   406  C  CB   . LEU   A 1 77  ? 13.22900  -6.75800  23.45800  1.000 16.24932  ?  229 LEU   A CB   1 
ATOM   407  C  CG   . LEU   A 1 77  ? 12.60900  -6.94200  22.07000  1.000 23.16372  ?  229 LEU   A CG   1 
ATOM   408  C  CD1  . LEU   A 1 77  ? 13.56600  -7.69100  21.14200  1.000 25.58682  ?  229 LEU   A CD1  1 
ATOM   409  C  CD2  . LEU   A 1 77  ? 11.27400  -7.66200  22.16600  1.000 25.83148  ?  229 LEU   A CD2  1 
ATOM   410  N  N    . VAL   A 1 78  ? 13.67900  -3.67500  23.17000  1.000 20.42537  ?  230 VAL   A N    1 
ATOM   411  C  CA   . VAL   A 1 78  ? 13.53500  -2.42700  22.42500  1.000 19.20523  ?  230 VAL   A CA   1 
ATOM   412  C  C    . VAL   A 1 78  ? 14.88100  -1.72900  22.28800  1.000 19.42260  ?  230 VAL   A C    1 
ATOM   413  O  O    . VAL   A 1 78  ? 15.21700  -1.20400  21.21800  1.000 19.52231  ?  230 VAL   A O    1 
ATOM   414  C  CB   . VAL   A 1 78  ? 12.48500  -1.52400  23.09700  1.000 20.41156  ?  230 VAL   A CB   1 
ATOM   415  C  CG1  . VAL   A 1 78  ? 12.53600  -0.11800  22.51800  1.000 18.03089  ?  230 VAL   A CG1  1 
ATOM   416  C  CG2  . VAL   A 1 78  ? 11.09700  -2.12100  22.92600  1.000 18.12551  ?  230 VAL   A CG2  1 
ATOM   417  N  N    . SER   A 1 79  ? 15.68200  -1.72800  23.35700  1.000 16.38671  ?  231 SER   A N    1 
ATOM   418  C  CA   . SER   A 1 79  ? 16.98700  -1.07400  23.32200  1.000 14.28207  ?  231 SER   A CA   1 
ATOM   419  C  C    . SER   A 1 79  ? 17.88700  -1.71000  22.27200  1.000 26.06129  ?  231 SER   A C    1 
ATOM   420  O  O    . SER   A 1 79  ? 18.53000  -1.01200  21.47800  1.000 16.75649  ?  231 SER   A O    1 
ATOM   421  C  CB   . SER   A 1 79  ? 17.64200  -1.15000  24.70200  1.000 15.12419  ?  231 SER   A CB   1 
ATOM   422  O  OG   . SER   A 1 79  ? 18.73300  -0.25100  24.80500  1.000 18.39746  ?  231 SER   A OG   1 
ATOM   423  N  N    . TYR   A 1 80  ? 17.95600  -3.04400  22.27700  1.000 16.65219  ?  232 TYR   A N    1 
ATOM   424  C  CA   . TYR   A 1 80  ? 18.66800  -3.79800  21.25100  1.000 20.60188  ?  232 TYR   A CA   1 
ATOM   425  C  C    . TYR   A 1 80  ? 18.18600  -3.42200  19.85500  1.000 23.57483  ?  232 TYR   A C    1 
ATOM   426  O  O    . TYR   A 1 80  ? 18.99600  -3.22500  18.94100  1.000 15.30137  ?  232 TYR   A O    1 
ATOM   427  C  CB   . TYR   A 1 80  ? 18.46600  -5.28700  21.53700  1.000 23.75359  ?  232 TYR   A CB   1 
ATOM   428  C  CG   . TYR   A 1 80  ? 18.98600  -6.28700  20.52800  1.000 26.80087  ?  232 TYR   A CG   1 
ATOM   429  C  CD1  . TYR   A 1 80  ? 20.29800  -6.73600  20.57700  1.000 27.99641  ?  232 TYR   A CD1  1 
ATOM   430  C  CD2  . TYR   A 1 80  ? 18.13900  -6.84000  19.57300  1.000 32.91319  ?  232 TYR   A CD2  1 
ATOM   431  C  CE1  . TYR   A 1 80  ? 20.76500  -7.67500  19.67600  1.000 38.95838  ?  232 TYR   A CE1  1 
ATOM   432  C  CE2  . TYR   A 1 80  ? 18.59700  -7.77900  18.67000  1.000 40.85654  ?  232 TYR   A CE2  1 
ATOM   433  C  CZ   . TYR   A 1 80  ? 19.91000  -8.19300  18.72700  1.000 42.11397  ?  232 TYR   A CZ   1 
ATOM   434  O  OH   . TYR   A 1 80  ? 20.37100  -9.12900  17.82800  1.000 54.83525  ?  232 TYR   A OH   1 
ATOM   435  N  N    . SER   A 1 81  ? 16.86800  -3.28200  19.68500  1.000 17.70360  ?  233 SER   A N    1 
ATOM   436  C  CA   . SER   A 1 81  ? 16.30200  -2.98500  18.37300  1.000 19.19298  ?  233 SER   A CA   1 
ATOM   437  C  C    . SER   A 1 81  ? 16.64600  -1.57300  17.91700  1.000 20.51458  ?  233 SER   A C    1 
ATOM   438  O  O    . SER   A 1 81  ? 16.87100  -1.34400  16.72400  1.000 18.36769  ?  233 SER   A O    1 
ATOM   439  C  CB   . SER   A 1 81  ? 14.78700  -3.17700  18.40000  1.000 23.52935  ?  233 SER   A CB   1 
ATOM   440  O  OG   . SER   A 1 81  ? 14.45600  -4.47100  18.86100  1.000 37.34525  ?  233 SER   A OG   1 
ATOM   441  N  N    . ILE   A 1 82  ? 16.67000  -0.60900  18.84300  1.000 17.34935  ?  234 ILE   A N    1 
ATOM   442  C  CA   . ILE   A 1 82  ? 17.08900  0.74900   18.49100  1.000 15.25789  ?  234 ILE   A CA   1 
ATOM   443  C  C    . ILE   A 1 82  ? 18.47900  0.72600   17.86800  1.000 16.25492  ?  234 ILE   A C    1 
ATOM   444  O  O    . ILE   A 1 82  ? 18.74200  1.40500   16.86500  1.000 16.20296  ?  234 ILE   A O    1 
ATOM   445  C  CB   . ILE   A 1 82  ? 17.04100  1.66500   19.73100  1.000 19.27270  ?  234 ILE   A CB   1 
ATOM   446  C  CG1  . ILE   A 1 82  ? 15.60300  1.84600   20.22000  1.000 21.38938  ?  234 ILE   A CG1  1 
ATOM   447  C  CG2  . ILE   A 1 82  ? 17.66300  3.02100   19.43000  1.000 18.60304  ?  234 ILE   A CG2  1 
ATOM   448  C  CD1  . ILE   A 1 82  ? 15.49900  2.67900   21.49500  1.000 14.84091  ?  234 ILE   A CD1  1 
ATOM   449  N  N    . GLN   A 1 83  ? 19.38900  -0.06000  18.44900  1.000 14.06718  ?  235 GLN   A N    1 
ATOM   450  C  CA   . GLN   A 1 83  ? 20.72200  -0.19500  17.86900  1.000 15.21231  ?  235 GLN   A CA   1 
ATOM   451  C  C    . GLN   A 1 83  ? 20.65200  -0.70500  16.43600  1.000 17.71250  ?  235 GLN   A C    1 
ATOM   452  O  O    . GLN   A 1 83  ? 21.41100  -0.25200  15.57000  1.000 14.62090  ?  235 GLN   A O    1 
ATOM   453  C  CB   . GLN   A 1 83  ? 21.57700  -1.13900  18.71600  1.000 21.12131  ?  235 GLN   A CB   1 
ATOM   454  C  CG   . GLN   A 1 83  ? 21.89100  -0.63900  20.11100  1.000 27.41246  ?  235 GLN   A CG   1 
ATOM   455  C  CD   . GLN   A 1 83  ? 22.77000  -1.61000  20.87500  1.000 45.77812  ?  235 GLN   A CD   1 
ATOM   456  O  OE1  . GLN   A 1 83  ? 23.78500  -2.08100  20.35700  1.000 31.03053  ?  235 GLN   A OE1  1 
ATOM   457  N  NE2  . GLN   A 1 83  ? 22.38200  -1.92200  22.10800  1.000 41.70052  ?  235 GLN   A NE2  1 
ATOM   458  N  N    . LYS   A 1 84  ? 19.77300  -1.66200  16.18900  1.000 15.89995  ?  236 LYS   A N    1 
ATOM   459  C  CA   . LYS   A 1 84  ? 19.62100  -2.19900  14.81900  1.000 15.57475  ?  236 LYS   A CA   1 
ATOM   460  C  C    . LYS   A 1 84  ? 19.07200  -1.09400  13.90000  1.000 21.43072  ?  236 LYS   A C    1 
ATOM   461  O  O    . LYS   A 1 84  ? 19.55900  -0.96800  12.82100  1.000 19.91077  ?  236 LYS   A O    1 
ATOM   462  C  CB   . LYS   A 1 84  ? 18.66500  -3.39500  14.81300  1.000 17.20146  ?  236 LYS   A CB   1 
ATOM   463  C  CG   . LYS   A 1 84  ? 19.16000  -4.65700  15.49800  1.000 24.09655  ?  236 LYS   A CG   1 
ATOM   464  C  CD   . LYS   A 1 84  ? 20.56700  -4.57900  15.93600  1.000 29.40508  ?  236 LYS   A CD   1 
ATOM   465  C  CE   . LYS   A 1 84  ? 21.24700  -5.91500  16.06700  1.000 36.87124  ?  236 LYS   A CE   1 
ATOM   466  N  NZ   . LYS   A 1 84  ? 22.70000  -5.73000  15.91000  1.000 42.34685  ?  236 LYS   A NZ   1 
ATOM   467  N  N    . VAL   A 1 85  ? 18.06400  -0.34800  14.33600  1.000 13.79131  ?  237 VAL   A N    1 
ATOM   468  C  CA   . VAL   A 1 85  ? 17.49500  0.71600   13.51100  1.000 15.49277  ?  237 VAL   A CA   1 
ATOM   469  C  C    . VAL   A 1 85  ? 18.56900  1.72700   13.13000  1.000 14.94548  ?  237 VAL   A C    1 
ATOM   470  O  O    . VAL   A 1 85  ? 18.65100  2.16300   11.97500  1.000 13.89698  ?  237 VAL   A O    1 
ATOM   471  C  CB   . VAL   A 1 85  ? 16.32100  1.39200   14.24200  1.000 16.13786  ?  237 VAL   A CB   1 
ATOM   472  C  CG1  . VAL   A 1 85  ? 15.79900  2.57400   13.43300  1.000 15.82888  ?  237 VAL   A CG1  1 
ATOM   473  C  CG2  . VAL   A 1 85  ? 15.20700  0.38400   14.50300  1.000 19.27325  ?  237 VAL   A CG2  1 
ATOM   474  N  N    . ILE   A 1 86  ? 19.41000  2.11400   14.09200  1.000 11.72002  ?  238 ILE   A N    1 
ATOM   475  C  CA   . ILE   A 1 86  ? 20.49100  3.05100   13.80400  1.000 12.49528  ?  238 ILE   A CA   1 
ATOM   476  C  C    . ILE   A 1 86  ? 21.45100  2.46000   12.78000  1.000 16.37630  ?  238 ILE   A C    1 
ATOM   477  O  O    . ILE   A 1 86  ? 21.88500  3.14800   11.84600  1.000 14.46642  ?  238 ILE   A O    1 
ATOM   478  C  CB   . ILE   A 1 86  ? 21.22300  3.44300   15.10000  1.000 15.88012  ?  238 ILE   A CB   1 
ATOM   479  C  CG1  . ILE   A 1 86  ? 20.26700  4.14100   16.06400  1.000 17.14379  ?  238 ILE   A CG1  1 
ATOM   480  C  CG2  . ILE   A 1 86  ? 22.41700  4.34600   14.78500  1.000 17.65084  ?  238 ILE   A CG2  1 
ATOM   481  C  CD1  . ILE   A 1 86  ? 20.77700  4.16900   17.48500  1.000 22.39603  ?  238 ILE   A CD1  1 
ATOM   482  N  N    . GLY   A 1 87  ? 21.78900  1.17700   12.92900  1.000 16.64477  ?  239 GLY   A N    1 
ATOM   483  C  CA   . GLY   A 1 87  ? 22.69600  0.54500   11.98200  1.000 14.29293  ?  239 GLY   A CA   1 
ATOM   484  C  C    . GLY   A 1 87  ? 22.12300  0.47400   10.57800  1.000 17.75806  ?  239 GLY   A C    1 
ATOM   485  O  O    . GLY   A 1 87  ? 22.85000  0.62500   9.59200   1.000 15.38388  ?  239 GLY   A O    1 
ATOM   486  N  N    . PHE   A 1 88  ? 20.81400  0.24200   10.46800  1.000 14.85482  ?  240 PHE   A N    1 
ATOM   487  C  CA   . PHE   A 1 88  ? 20.15800  0.23300   9.16300   1.000 16.90645  ?  240 PHE   A CA   1 
ATOM   488  C  C    . PHE   A 1 88  ? 20.10800  1.63600   8.56400   1.000 12.78400  ?  240 PHE   A C    1 
ATOM   489  O  O    . PHE   A 1 88  ? 20.44600  1.83400   7.39000   1.000 17.29544  ?  240 PHE   A O    1 
ATOM   490  C  CB   . PHE   A 1 88  ? 18.75000  -0.35300  9.30400   1.000 15.93674  ?  240 PHE   A CB   1 
ATOM   491  C  CG   . PHE   A 1 88  ? 17.93100  -0.31000  8.04300   1.000 11.84013  ?  240 PHE   A CG   1 
ATOM   492  C  CD1  . PHE   A 1 88  ? 18.14200  -1.23200  7.03000   1.000 14.14386  ?  240 PHE   A CD1  1 
ATOM   493  C  CD2  . PHE   A 1 88  ? 16.92700  0.63500   7.88500   1.000 17.08357  ?  240 PHE   A CD2  1 
ATOM   494  C  CE1  . PHE   A 1 88  ? 17.37800  -1.20400  5.87600   1.000 11.86839  ?  240 PHE   A CE1  1 
ATOM   495  C  CE2  . PHE   A 1 88  ? 16.15700  0.66600   6.73300   1.000 14.20306  ?  240 PHE   A CE2  1 
ATOM   496  C  CZ   . PHE   A 1 88  ? 16.38300  -0.25500  5.72900   1.000 11.05134  ?  240 PHE   A CZ   1 
ATOM   497  N  N    . ALA   A 1 89  ? 19.70700  2.62600   9.36700   1.000 12.64961  ?  241 ALA   A N    1 
ATOM   498  C  CA   . ALA   A 1 89  ? 19.54000  3.98700   8.86300   1.000 12.44626  ?  241 ALA   A CA   1 
ATOM   499  C  C    . ALA   A 1 89  ? 20.84900  4.56800   8.33800   1.000 17.54957  ?  241 ALA   A C    1 
ATOM   500  O  O    . ALA   A 1 89  ? 20.85000  5.33500   7.36800   1.000 14.51005  ?  241 ALA   A O    1 
ATOM   501  C  CB   . ALA   A 1 89  ? 18.97300  4.88500   9.96100   1.000 11.89558  ?  241 ALA   A CB   1 
ATOM   502  N  N    A LYS   A 1 90  ? 21.97200  4.22800   8.97000   0.570 15.55614  ?  242 LYS   A N    1 
ATOM   503  N  N    B LYS   A 1 90  ? 21.97300  4.21500   8.96400   0.430 15.57093  ?  242 LYS   A N    1 
ATOM   504  C  CA   A LYS   A 1 90  ? 23.24800  4.78400   8.53200   0.570 17.86086  ?  242 LYS   A CA   1 
ATOM   505  C  CA   B LYS   A 1 90  ? 23.25800  4.76200   8.54200   0.430 17.86630  ?  242 LYS   A CA   1 
ATOM   506  C  C    A LYS   A 1 90  ? 23.66900  4.28000   7.15600   0.570 16.57679  ?  242 LYS   A C    1 
ATOM   507  C  C    B LYS   A 1 90  ? 23.67300  4.27500   7.15900   0.430 16.59266  ?  242 LYS   A C    1 
ATOM   508  O  O    A LYS   A 1 90  ? 24.56300  4.87700   6.54600   0.570 16.30887  ?  242 LYS   A O    1 
ATOM   509  O  O    B LYS   A 1 90  ? 24.56900  4.87000   6.55000   0.430 16.34092  ?  242 LYS   A O    1 
ATOM   510  C  CB   A LYS   A 1 90  ? 24.33700  4.48300   9.56700   0.570 19.43460  ?  242 LYS   A CB   1 
ATOM   511  C  CB   B LYS   A 1 90  ? 24.33600  4.42500   9.57700   0.430 19.44334  ?  242 LYS   A CB   1 
ATOM   512  C  CG   A LYS   A 1 90  ? 24.90400  3.08100   9.49300   0.570 24.12211  ?  242 LYS   A CG   1 
ATOM   513  C  CG   B LYS   A 1 90  ? 24.94900  3.04400   9.41400   0.430 24.10990  ?  242 LYS   A CG   1 
ATOM   514  C  CD   A LYS   A 1 90  ? 25.68300  2.73300   10.75200  0.570 30.46892  ?  242 LYS   A CD   1 
ATOM   515  C  CD   B LYS   A 1 90  ? 25.66200  2.58500   10.68400  0.430 30.02563  ?  242 LYS   A CD   1 
ATOM   516  C  CE   A LYS   A 1 90  ? 26.30900  1.35300   10.64600  0.570 26.68397  ?  242 LYS   A CE   1 
ATOM   517  C  CE   B LYS   A 1 90  ? 26.39200  3.73400   11.37000  0.430 33.23359  ?  242 LYS   A CE   1 
ATOM   518  N  NZ   A LYS   A 1 90  ? 25.60800  0.51500   9.63800   0.570 23.47403  ?  242 LYS   A NZ   1 
ATOM   519  N  NZ   B LYS   A 1 90  ? 27.29400  3.26200   12.45800  0.430 22.74937  ?  242 LYS   A NZ   1 
ATOM   520  N  N    . MET   A 1 91  ? 23.04300  3.21700   6.64800   1.000 12.51774  ?  243 MET   A N    1 
ATOM   521  C  CA   . MET   A 1 91  ? 23.32800  2.70900   5.31100   1.000 15.55027  ?  243 MET   A CA   1 
ATOM   522  C  C    . MET   A 1 91  ? 22.37400  3.24200   4.24800   1.000 13.82765  ?  243 MET   A C    1 
ATOM   523  O  O    . MET   A 1 91  ? 22.61700  3.01700   3.05800   1.000 13.25660  ?  243 MET   A O    1 
ATOM   524  C  CB   . MET   A 1 91  ? 23.27500  1.17700   5.29400   1.000 12.30907  ?  243 MET   A CB   1 
ATOM   525  C  CG   . MET   A 1 91  ? 24.11900  0.49200   6.35100   1.000 22.27306  ?  243 MET   A CG   1 
ATOM   526  S  SD   . MET   A 1 91  ? 25.84000  1.01700   6.31800   1.000 31.10142  ?  243 MET   A SD   1 
ATOM   527  C  CE   . MET   A 1 91  ? 26.44800  0.18800   4.84800   1.000 24.36733  ?  243 MET   A CE   1 
ATOM   528  N  N    . ILE   A 1 92  ? 21.29700  3.91900   4.63600   1.000 12.34603  ?  244 ILE   A N    1 
ATOM   529  C  CA   . ILE   A 1 92  ? 20.38200  4.51400   3.66100   1.000 13.90452  ?  244 ILE   A CA   1 
ATOM   530  C  C    . ILE   A 1 92  ? 21.16000  5.54000   2.84700   1.000 9.04279   ?  244 ILE   A C    1 
ATOM   531  O  O    . ILE   A 1 92  ? 21.76600  6.45200   3.42900   1.000 12.59909  ?  244 ILE   A O    1 
ATOM   532  C  CB   . ILE   A 1 92  ? 19.16200  5.15900   4.33700   1.000 14.86389  ?  244 ILE   A CB   1 
ATOM   533  C  CG1  . ILE   A 1 92  ? 18.38400  4.12300   5.14700   1.000 13.82950  ?  244 ILE   A CG1  1 
ATOM   534  C  CG2  . ILE   A 1 92  ? 18.25100  5.80900   3.28500   1.000 17.90183  ?  244 ILE   A CG2  1 
ATOM   535  C  CD1  . ILE   A 1 92  ? 17.20100  4.70500   5.90600   1.000 10.33286  ?  244 ILE   A CD1  1 
ATOM   536  N  N    . PRO   A 1 93  ? 21.18800  5.42900   1.51800   1.000 16.33674  ?  245 PRO   A N    1 
ATOM   537  C  CA   . PRO   A 1 93  ? 21.99300  6.36400   0.72000   1.000 18.33819  ?  245 PRO   A CA   1 
ATOM   538  C  C    . PRO   A 1 93  ? 21.57000  7.80300   0.98100   1.000 14.02086  ?  245 PRO   A C    1 
ATOM   539  O  O    . PRO   A 1 93  ? 20.39200  8.15300   0.88000   1.000 19.31460  ?  245 PRO   A O    1 
ATOM   540  C  CB   . PRO   A 1 93  ? 21.70400  5.93700   -0.72500  1.000 25.15571  ?  245 PRO   A CB   1 
ATOM   541  C  CG   . PRO   A 1 93  ? 21.29700  4.50900   -0.62000  1.000 21.62668  ?  245 PRO   A CG   1 
ATOM   542  C  CD   . PRO   A 1 93  ? 20.54600  4.40100   0.68300   1.000 15.04439  ?  245 PRO   A CD   1 
ATOM   543  N  N    . GLY   A 1 94  ? 22.54300  8.62700   1.36400   1.000 16.30084  ?  246 GLY   A N    1 
ATOM   544  C  CA   . GLY   A 1 94  ? 22.30500  10.01900  1.66300   1.000 20.37768  ?  246 GLY   A CA   1 
ATOM   545  C  C    . GLY   A 1 94  ? 22.07600  10.34200  3.12600   1.000 19.41225  ?  246 GLY   A C    1 
ATOM   546  O  O    . GLY   A 1 94  ? 22.27400  11.49500  3.52300   1.000 19.18290  ?  246 GLY   A O    1 
ATOM   547  N  N    . PHE   A 1 95  ? 21.67500  9.35900   3.94300   1.000 15.27739  ?  247 PHE   A N    1 
ATOM   548  C  CA   . PHE   A 1 95  ? 21.32800  9.64200   5.33600   1.000 15.64060  ?  247 PHE   A CA   1 
ATOM   549  C  C    . PHE   A 1 95  ? 22.51200  10.22900  6.10000   1.000 16.79309  ?  247 PHE   A C    1 
ATOM   550  O  O    . PHE   A 1 95  ? 22.37200  11.24000  6.79600   1.000 14.31773  ?  247 PHE   A O    1 
ATOM   551  C  CB   . PHE   A 1 95  ? 20.81200  8.37600   6.02500   1.000 16.65143  ?  247 PHE   A CB   1 
ATOM   552  C  CG   . PHE   A 1 95  ? 20.35400  8.59900   7.44800   1.000 14.39334  ?  247 PHE   A CG   1 
ATOM   553  C  CD1  . PHE   A 1 95  ? 19.05100  8.99300   7.72300   1.000 11.73092  ?  247 PHE   A CD1  1 
ATOM   554  C  CD2  . PHE   A 1 95  ? 21.22500  8.40400   8.51100   1.000 12.40267  ?  247 PHE   A CD2  1 
ATOM   555  C  CE1  . PHE   A 1 95  ? 18.63300  9.20200   9.03200   1.000 11.26466  ?  247 PHE   A CE1  1 
ATOM   556  C  CE2  . PHE   A 1 95  ? 20.81200  8.60400   9.81500   1.000 15.21049  ?  247 PHE   A CE2  1 
ATOM   557  C  CZ   . PHE   A 1 95  ? 19.51400  9.00700   10.07700  1.000 14.53155  ?  247 PHE   A CZ   1 
ATOM   558  N  N    A ARG   A 1 96  ? 23.69100  9.61500   5.97400   0.580 16.74057  ?  248 ARG   A N    1 
ATOM   559  N  N    B ARG   A 1 96  ? 23.69100  9.61100   5.98000   0.420 16.81926  ?  248 ARG   A N    1 
ATOM   560  C  CA   A ARG   A 1 96  ? 24.86000  10.13200  6.67500   0.580 21.15782  ?  248 ARG   A CA   1 
ATOM   561  C  CA   B ARG   A 1 96  ? 24.86600  10.12900  6.67600   0.420 21.17413  ?  248 ARG   A CA   1 
ATOM   562  C  C    A ARG   A 1 96  ? 25.34800  11.46000  6.11200   0.580 19.97142  ?  248 ARG   A C    1 
ATOM   563  C  C    B ARG   A 1 96  ? 25.33700  11.46800  6.12200   0.420 20.02863  ?  248 ARG   A C    1 
ATOM   564  O  O    A ARG   A 1 96  ? 26.22400  12.08300  6.72200   0.580 23.95834  ?  248 ARG   A O    1 
ATOM   565  O  O    B ARG   A 1 96  ? 26.19300  12.10500  6.74500   0.420 23.95293  ?  248 ARG   A O    1 
ATOM   566  C  CB   A ARG   A 1 96  ? 25.99700  9.10800   6.64300   0.580 24.91965  ?  248 ARG   A CB   1 
ATOM   567  C  CB   B ARG   A 1 96  ? 26.02200  9.12200   6.62000   0.420 24.92041  ?  248 ARG   A CB   1 
ATOM   568  C  CG   A ARG   A 1 96  ? 25.88500  8.03000   7.71000   0.580 28.70820  ?  248 ARG   A CG   1 
ATOM   569  C  CG   B ARG   A 1 96  ? 25.81300  7.84700   7.43500   0.420 27.98977  ?  248 ARG   A CG   1 
ATOM   570  C  CD   A ARG   A 1 96  ? 27.12800  7.98000   8.59900   0.580 36.51279  ?  248 ARG   A CD   1 
ATOM   571  C  CD   B ARG   A 1 96  ? 26.14400  8.02500   8.92000   0.420 33.04266  ?  248 ARG   A CD   1 
ATOM   572  N  NE   A ARG   A 1 96  ? 27.28200  9.17400   9.43000   0.580 40.37108  ?  248 ARG   A NE   1 
ATOM   573  N  NE   B ARG   A 1 96  ? 27.49600  8.53200   9.16700   0.420 37.48953  ?  248 ARG   A NE   1 
ATOM   574  C  CZ   A ARG   A 1 96  ? 26.48900  9.49000   10.45000  0.580 18.91382  ?  248 ARG   A CZ   1 
ATOM   575  C  CZ   B ARG   A 1 96  ? 28.60000  7.78900   9.15200   0.420 35.19752  ?  248 ARG   A CZ   1 
ATOM   576  N  NH1  A ARG   A 1 96  ? 26.70700  10.59600  11.14800  0.580 24.85215  ?  248 ARG   A NH1  1 
ATOM   577  N  NH1  B ARG   A 1 96  ? 29.77800  8.34700   9.39600   0.420 36.69550  ?  248 ARG   A NH1  1 
ATOM   578  N  NH2  A ARG   A 1 96  ? 25.47400  8.70400   10.77500  0.580 35.20406  ?  248 ARG   A NH2  1 
ATOM   579  N  NH2  B ARG   A 1 96  ? 28.53200  6.49100   8.88800   0.420 39.74546  ?  248 ARG   A NH2  1 
ATOM   580  N  N    . ASP   A 1 97  ? 24.80900  11.90700  4.98000   1.000 21.26303  ?  249 ASP   A N    1 
ATOM   581  C  CA   . ASP   A 1 97  ? 25.16300  13.19900  4.40500   1.000 25.67026  ?  249 ASP   A CA   1 
ATOM   582  C  C    . ASP   A 1 97  ? 24.24900  14.32800  4.87000   1.000 32.26604  ?  249 ASP   A C    1 
ATOM   583  O  O    . ASP   A 1 97  ? 24.43900  15.47200  4.44600   1.000 24.23043  ?  249 ASP   A O    1 
ATOM   584  C  CB   . ASP   A 1 97  ? 25.15400  13.12000  2.87700   1.000 23.40347  ?  249 ASP   A CB   1 
ATOM   585  C  CG   . ASP   A 1 97  ? 26.31500  12.30800  2.33100   1.000 26.86575  ?  249 ASP   A CG   1 
ATOM   586  O  OD1  . ASP   A 1 97  ? 27.32600  12.15900  3.04800   1.000 21.03399  ?  249 ASP   A OD1  1 
ATOM   587  O  OD2  . ASP   A 1 97  ? 26.21700  11.81900  1.19000   1.000 27.21043  ?  249 ASP   A OD2  1 
ATOM   588  N  N    . LEU   A 1 98  ? 23.25800  14.03000  5.70700   1.000 20.31615  ?  250 LEU   A N    1 
ATOM   589  C  CA   . LEU   A 1 98  ? 22.49600  15.04900  6.40800   1.000 17.34588  ?  250 LEU   A CA   1 
ATOM   590  C  C    . LEU   A 1 98  ? 23.28600  15.53500  7.61900   1.000 20.21899  ?  250 LEU   A C    1 
ATOM   591  O  O    . LEU   A 1 98  ? 24.25300  14.89800  8.05000   1.000 18.37381  ?  250 LEU   A O    1 
ATOM   592  C  CB   . LEU   A 1 98  ? 21.14000  14.49100  6.85000   1.000 14.15335  ?  250 LEU   A CB   1 
ATOM   593  C  CG   . LEU   A 1 98  ? 20.27700  13.82600  5.76700   1.000 12.42543  ?  250 LEU   A CG   1 
ATOM   594  C  CD1  . LEU   A 1 98  ? 19.08400  13.09300  6.37600   1.000 11.61934  ?  250 LEU   A CD1  1 
ATOM   595  C  CD2  . LEU   A 1 98  ? 19.79900  14.85300  4.74400   1.000 14.86569  ?  250 LEU   A CD2  1 
ATOM   596  N  N    . THR   A 1 99  ? 22.87400  16.67700  8.17100   1.000 13.70883  ?  251 THR   A N    1 
ATOM   597  C  CA   . THR   A 1 99  ? 23.50900  17.13700  9.40000   1.000 16.43177  ?  251 THR   A CA   1 
ATOM   598  C  C    . THR   A 1 99  ? 23.24100  16.13300  10.51200  1.000 20.74698  ?  251 THR   A C    1 
ATOM   599  O  O    . THR   A 1 99  ? 22.24300  15.40700  10.49300  1.000 16.83814  ?  251 THR   A O    1 
ATOM   600  C  CB   . THR   A 1 99  ? 23.00100  18.52200  9.81700   1.000 21.51235  ?  251 THR   A CB   1 
ATOM   601  O  OG1  . THR   A 1 99  ? 21.66800  18.41900  10.33000  1.000 19.11558  ?  251 THR   A OG1  1 
ATOM   602  C  CG2  . THR   A 1 99  ? 23.02200  19.49000  8.64500   1.000 18.57711  ?  251 THR   A CG2  1 
ATOM   603  N  N    A SER   A 1 100 ? 24.15700  16.08900  11.48400  0.530 17.41393  ?  252 SER   A N    1 
ATOM   604  N  N    B SER   A 1 100 ? 24.15200  16.08400  11.48700  0.470 17.43308  ?  252 SER   A N    1 
ATOM   605  C  CA   A SER   A 1 100 ? 23.98700  15.19200  12.62200  0.530 17.03886  ?  252 SER   A CA   1 
ATOM   606  C  CA   B SER   A 1 100 ? 23.96700  15.17000  12.60900  0.470 17.02999  ?  252 SER   A CA   1 
ATOM   607  C  C    A SER   A 1 100 ? 22.69200  15.48900  13.36800  0.530 16.42060  ?  252 SER   A C    1 
ATOM   608  C  C    B SER   A 1 100 ? 22.69500  15.48800  13.38400  0.470 16.43141  ?  252 SER   A C    1 
ATOM   609  O  O    A SER   A 1 100 ? 22.02500  14.57000  13.85900  0.530 16.14852  ?  252 SER   A O    1 
ATOM   610  O  O    B SER   A 1 100 ? 22.04600  14.57700  13.90900  0.470 16.16182  ?  252 SER   A O    1 
ATOM   611  C  CB   A SER   A 1 100 ? 25.18300  15.30700  13.56500  0.530 21.74541  ?  252 SER   A CB   1 
ATOM   612  C  CB   B SER   A 1 100 ? 25.18100  15.21500  13.53700  0.470 21.70984  ?  252 SER   A CB   1 
ATOM   613  O  OG   A SER   A 1 100 ? 26.36800  14.85200  12.93900  0.530 21.46185  ?  252 SER   A OG   1 
ATOM   614  O  OG   B SER   A 1 100 ? 25.42700  16.53100  13.99300  0.470 18.95036  ?  252 SER   A OG   1 
ATOM   615  N  N    . ASP   A 1 101 ? 22.31900  16.76700  13.45800  1.000 21.17892  ?  253 ASP   A N    1 
ATOM   616  C  CA   . ASP   A 1 101 ? 21.07500  17.13400  14.12900  1.000 21.12153  ?  253 ASP   A CA   1 
ATOM   617  C  C    . ASP   A 1 101 ? 19.87000  16.51100  13.43900  1.000 14.34198  ?  253 ASP   A C    1 
ATOM   618  O  O    . ASP   A 1 101 ? 18.98500  15.95000  14.09800  1.000 18.00474  ?  253 ASP   A O    1 
ATOM   619  C  CB   . ASP   A 1 101 ? 20.91400  18.64900  14.16900  1.000 22.91863  ?  253 ASP   A CB   1 
ATOM   620  C  CG   . ASP   A 1 101 ? 21.41900  19.24900  15.44800  1.000 42.86243  ?  253 ASP   A CG   1 
ATOM   621  O  OD1  . ASP   A 1 101 ? 21.25300  20.46800  15.62200  1.000 53.65391  ?  253 ASP   A OD1  1 
ATOM   622  O  OD2  . ASP   A 1 101 ? 21.98200  18.50500  16.27600  1.000 40.23420  ?  253 ASP   A OD2  1 
ATOM   623  N  N    . ASP   A 1 102 ? 19.80300  16.62500  12.11100  1.000 16.67307  ?  254 ASP   A N    1 
ATOM   624  C  CA   . ASP   A 1 102 ? 18.67400  16.04700  11.38900  1.000 17.75872  ?  254 ASP   A CA   1 
ATOM   625  C  C    . ASP   A 1 102 ? 18.68800  14.52900  11.47900  1.000 17.29596  ?  254 ASP   A C    1 
ATOM   626  O  O    . ASP   A 1 102 ? 17.63000  13.90200  11.60900  1.000 15.03580  ?  254 ASP   A O    1 
ATOM   627  C  CB   . ASP   A 1 102 ? 18.68100  16.50200  9.93100   1.000 16.50414  ?  254 ASP   A CB   1 
ATOM   628  C  CG   . ASP   A 1 102 ? 18.08500  17.88400  9.75200   1.000 26.11353  ?  254 ASP   A CG   1 
ATOM   629  O  OD1  . ASP   A 1 102 ? 18.19000  18.44600  8.64200   1.000 19.02411  ?  254 ASP   A OD1  1 
ATOM   630  O  OD2  . ASP   A 1 102 ? 17.51100  18.41000  10.72800  1.000 26.21677  ?  254 ASP   A OD2  1 
ATOM   631  N  N    . GLN   A 1 103 ? 19.87500  13.92100  11.42200  1.000 11.45471  ?  255 GLN   A N    1 
ATOM   632  C  CA   . GLN   A 1 103 ? 19.97100  12.48000  11.62700  1.000 11.62662  ?  255 GLN   A CA   1 
ATOM   633  C  C    . GLN   A 1 103 ? 19.39300  12.08200  12.97600  1.000 12.57203  ?  255 GLN   A C    1 
ATOM   634  O  O    . GLN   A 1 103 ? 18.64500  11.10300  13.07600  1.000 13.96634  ?  255 GLN   A O    1 
ATOM   635  C  CB   . GLN   A 1 103 ? 21.42600  12.02500  11.51200  1.000 16.23585  ?  255 GLN   A CB   1 
ATOM   636  C  CG   . GLN   A 1 103 ? 22.02000  12.21300  10.12800  1.000 15.13452  ?  255 GLN   A CG   1 
ATOM   637  C  CD   . GLN   A 1 103 ? 23.44700  11.71800  10.04100  1.000 24.91316  ?  255 GLN   A CD   1 
ATOM   638  O  OE1  . GLN   A 1 103 ? 23.75700  10.62100  10.49600  1.000 18.90180  ?  255 GLN   A OE1  1 
ATOM   639  N  NE2  . GLN   A 1 103 ? 24.32400  12.52800  9.45500   1.000 17.70160  ?  255 GLN   A NE2  1 
ATOM   640  N  N    . ILE   A 1 104 ? 19.71400  12.84400  14.02400  1.000 14.41183  ?  256 ILE   A N    1 
ATOM   641  C  CA   . ILE   A 1 104 ? 19.22800  12.52400  15.36100  1.000 15.15028  ?  256 ILE   A CA   1 
ATOM   642  C  C    . ILE   A 1 104 ? 17.71500  12.69200  15.43400  1.000 14.67851  ?  256 ILE   A C    1 
ATOM   643  O  O    . ILE   A 1 104 ? 17.00500  11.83400  15.97200  1.000 14.52044  ?  256 ILE   A O    1 
ATOM   644  C  CB   . ILE   A 1 104 ? 19.94900  13.39500  16.40700  1.000 19.10950  ?  256 ILE   A CB   1 
ATOM   645  C  CG1  . ILE   A 1 104 ? 21.37000  12.87500  16.63500  1.000 21.88981  ?  256 ILE   A CG1  1 
ATOM   646  C  CG2  . ILE   A 1 104 ? 19.16800  13.42900  17.70900  1.000 15.40957  ?  256 ILE   A CG2  1 
ATOM   647  C  CD1  . ILE   A 1 104 ? 22.23400  13.81200  17.44800  1.000 19.00124  ?  256 ILE   A CD1  1 
ATOM   648  N  N    . VAL   A 1 105 ? 17.19900  13.79400  14.88700  1.000 12.74020  ?  257 VAL   A N    1 
ATOM   649  C  CA   . VAL   A 1 105 ? 15.75500  14.03000  14.90100  1.000 14.22656  ?  257 VAL   A CA   1 
ATOM   650  C  C    . VAL   A 1 105 ? 15.02000  12.91600  14.16500  1.000 12.95928  ?  257 VAL   A C    1 
ATOM   651  O  O    . VAL   A 1 105 ? 13.99400  12.41000  14.63800  1.000 13.17821  ?  257 VAL   A O    1 
ATOM   652  C  CB   . VAL   A 1 105 ? 15.43700  15.41100  14.30000  1.000 22.51701  ?  257 VAL   A CB   1 
ATOM   653  C  CG1  . VAL   A 1 105 ? 13.95600  15.52600  13.99400  1.000 28.97583  ?  257 VAL   A CG1  1 
ATOM   654  C  CG2  . VAL   A 1 105 ? 15.87600  16.51900  15.25200  1.000 19.68853  ?  257 VAL   A CG2  1 
ATOM   655  N  N    . LEU   A 1 106 ? 15.54000  12.50500  13.00600  1.000 12.53928  ?  258 LEU   A N    1 
ATOM   656  C  CA   . LEU   A 1 106 ? 14.86900  11.47500  12.22000  1.000 13.12345  ?  258 LEU   A CA   1 
ATOM   657  C  C    . LEU   A 1 106 ? 14.84500  10.14100  12.95500  1.000 11.26477  ?  258 LEU   A C    1 
ATOM   658  O  O    . LEU   A 1 106 ? 13.83700  9.42600   12.92200  1.000 13.31747  ?  258 LEU   A O    1 
ATOM   659  C  CB   . LEU   A 1 106 ? 15.54900  11.32500  10.85700  1.000 13.98049  ?  258 LEU   A CB   1 
ATOM   660  C  CG   . LEU   A 1 106 ? 15.40300  12.50800  9.89500   1.000 15.41605  ?  258 LEU   A CG   1 
ATOM   661  C  CD1  . LEU   A 1 106 ? 16.32700  12.34500  8.69000   1.000 15.14395  ?  258 LEU   A CD1  1 
ATOM   662  C  CD2  . LEU   A 1 106 ? 13.96100  12.67600  9.45400   1.000 16.78313  ?  258 LEU   A CD2  1 
ATOM   663  N  N    . LEU   A 1 107 ? 15.94000  9.79300   13.63000  1.000 11.34185  ?  259 LEU   A N    1 
ATOM   664  C  CA   . LEU   A 1 107 ? 15.99000  8.51500   14.33600  1.000 14.77261  ?  259 LEU   A CA   1 
ATOM   665  C  C    . LEU   A 1 107 ? 15.13400  8.54000   15.60000  1.000 15.80007  ?  259 LEU   A C    1 
ATOM   666  O  O    . LEU   A 1 107 ? 14.43400  7.56400   15.90000  1.000 13.94764  ?  259 LEU   A O    1 
ATOM   667  C  CB   . LEU   A 1 107 ? 17.44000  8.15600   14.66200  1.000 11.48160  ?  259 LEU   A CB   1 
ATOM   668  C  CG   . LEU   A 1 107 ? 18.19200  7.56200   13.46700  1.000 18.57714  ?  259 LEU   A CG   1 
ATOM   669  C  CD1  . LEU   A 1 107 ? 19.69500  7.62500   13.67600  1.000 22.23506  ?  259 LEU   A CD1  1 
ATOM   670  C  CD2  . LEU   A 1 107 ? 17.74200  6.12600   13.20700  1.000 19.83088  ?  259 LEU   A CD2  1 
ATOM   671  N  N    . LYS   A 1 108 ? 15.16900  9.64300   16.35100  1.000 15.27895  ?  260 LYS   A N    1 
ATOM   672  C  CA   . LYS   A 1 108 ? 14.33900  9.73300   17.55000  1.000 11.96494  ?  260 LYS   A CA   1 
ATOM   673  C  C    . LYS   A 1 108 ? 12.85900  9.61300   17.21300  1.000 18.74010  ?  260 LYS   A C    1 
ATOM   674  O  O    . LYS   A 1 108 ? 12.09100  8.98900   17.95600  1.000 16.58059  ?  260 LYS   A O    1 
ATOM   675  C  CB   . LYS   A 1 108 ? 14.59700  11.04800  18.28400  1.000 17.04163  ?  260 LYS   A CB   1 
ATOM   676  C  CG   . LYS   A 1 108 ? 15.93100  11.13900  18.99700  1.000 18.52451  ?  260 LYS   A CG   1 
ATOM   677  C  CD   . LYS   A 1 108 ? 16.14400  12.54000  19.54600  1.000 17.80857  ?  260 LYS   A CD   1 
ATOM   678  C  CE   . LYS   A 1 108 ? 15.16000  12.86300  20.66400  1.000 25.59291  ?  260 LYS   A CE   1 
ATOM   679  N  NZ   . LYS   A 1 108 ? 15.52000  12.18200  21.93200  1.000 25.26953  ?  260 LYS   A NZ   1 
ATOM   680  N  N    A SER   A 1 109 ? 12.43400  10.20200  16.09500  0.570 15.94021  ?  261 SER   A N    1 
ATOM   681  N  N    C SER   A 1 109 ? 12.44100  10.20500  16.09400  0.430 15.94915  ?  261 SER   A N    1 
ATOM   682  C  CA   A SER   A 1 109 ? 11.01100  10.22400  15.77700  0.570 16.83029  ?  261 SER   A CA   1 
ATOM   683  C  CA   C SER   A 1 109 ? 11.02600  10.24300  15.74800  0.430 16.84701  ?  261 SER   A CA   1 
ATOM   684  C  C    A SER   A 1 109 ? 10.54300  8.94700   15.09100  0.570 17.80875  ?  261 SER   A C    1 
ATOM   685  C  C    C SER   A 1 109 ? 10.55200  8.95000   15.10000  0.430 17.79206  ?  261 SER   A C    1 
ATOM   686  O  O    A SER   A 1 109 ? 9.37200   8.57800   15.22400  0.570 19.05187  ?  261 SER   A O    1 
ATOM   687  O  O    C SER   A 1 109 ? 9.38700   8.57500   15.26700  0.430 19.04616  ?  261 SER   A O    1 
ATOM   688  C  CB   A SER   A 1 109 ? 10.68300  11.43700  14.90400  0.570 19.03027  ?  261 SER   A CB   1 
ATOM   689  C  CB   C SER   A 1 109 ? 10.74900  11.42500  14.81800  0.430 18.96924  ?  261 SER   A CB   1 
ATOM   690  O  OG   A SER   A 1 109 ? 11.58000  11.53900  13.81400  0.570 18.55403  ?  261 SER   A OG   1 
ATOM   691  O  OG   C SER   A 1 109 ? 11.26400  12.63000  15.35900  0.430 20.18351  ?  261 SER   A OG   1 
ATOM   692  N  N    . SER   A 1 110 ? 11.42400  8.25200   14.37100  1.000 13.31055  ?  262 SER   A N    1 
ATOM   693  C  CA   . SER   A 1 110 ? 11.01800  7.06600   13.62300  1.000 15.14196  ?  262 SER   A CA   1 
ATOM   694  C  C    . SER   A 1 110 ? 11.32100  5.74500   14.32200  1.000 13.62797  ?  262 SER   A C    1 
ATOM   695  O  O    . SER   A 1 110 ? 10.79100  4.71300   13.89700  1.000 14.20716  ?  262 SER   A O    1 
ATOM   696  C  CB   . SER   A 1 110 ? 11.68700  7.05300   12.24300  1.000 12.77093  ?  262 SER   A CB   1 
ATOM   697  O  OG   . SER   A 1 110 ? 13.08200  6.81600   12.36300  1.000 15.17157  ?  262 SER   A OG   1 
ATOM   698  N  N    . ALA   A 1 111 ? 12.15700  5.74300   15.36700  1.000 13.22045  ?  263 ALA   A N    1 
ATOM   699  C  CA   . ALA   A 1 111 ? 12.63500  4.48500   15.94100  1.000 12.73729  ?  263 ALA   A CA   1 
ATOM   700  C  C    . ALA   A 1 111 ? 11.48100  3.55900   16.31300  1.000 17.08289  ?  263 ALA   A C    1 
ATOM   701  O  O    . ALA   A 1 111 ? 11.48200  2.37200   15.96400  1.000 13.24340  ?  263 ALA   A O    1 
ATOM   702  C  CB   . ALA   A 1 111 ? 13.51200  4.76700   17.16300  1.000 15.24383  ?  263 ALA   A CB   1 
ATOM   703  N  N    . ILE   A 1 112 ? 10.47000  4.09100   17.00100  1.000 15.43197  ?  264 ILE   A N    1 
ATOM   704  C  CA   . ILE   A 1 112 ? 9.36500   3.23800   17.43300  1.000 13.53750  ?  264 ILE   A CA   1 
ATOM   705  C  C    . ILE   A 1 112 ? 8.59300   2.70300   16.23200  1.000 12.56352  ?  264 ILE   A C    1 
ATOM   706  O  O    . ILE   A 1 112 ? 8.14300   1.54900   16.23400  1.000 16.36881  ?  264 ILE   A O    1 
ATOM   707  C  CB   . ILE   A 1 112 ? 8.45400   3.99100   18.42300  1.000 20.81988  ?  264 ILE   A CB   1 
ATOM   708  C  CG1  . ILE   A 1 112 ? 7.54700   3.00200   19.14800  1.000 25.64270  ?  264 ILE   A CG1  1 
ATOM   709  C  CG2  . ILE   A 1 112 ? 7.64300   5.07600   17.73100  1.000 24.10819  ?  264 ILE   A CG2  1 
ATOM   710  C  CD1  . ILE   A 1 112 ? 8.31900   2.05100   20.01900  1.000 26.81585  ?  264 ILE   A CD1  1 
ATOM   711  N  N    . GLU   A 1 113 ? 8.44700   3.51300   15.17800  1.000 13.60034  ?  265 GLU   A N    1 
ATOM   712  C  CA   . GLU   A 1 113 ? 7.73700   3.05200   13.99000  1.000 13.47460  ?  265 GLU   A CA   1 
ATOM   713  C  C    . GLU   A 1 113 ? 8.50100   1.93200   13.29300  1.000 15.82322  ?  265 GLU   A C    1 
ATOM   714  O  O    . GLU   A 1 113 ? 7.90600   0.93600   12.86700  1.000 14.73573  ?  265 GLU   A O    1 
ATOM   715  C  CB   . GLU   A 1 113 ? 7.49700   4.22000   13.03300  1.000 12.92120  ?  265 GLU   A CB   1 
ATOM   716  C  CG   . GLU   A 1 113 ? 6.50100   5.25900   13.53400  1.000 13.93707  ?  265 GLU   A CG   1 
ATOM   717  C  CD   . GLU   A 1 113 ? 6.38500   6.45700   12.60300  1.000 23.00715  ?  265 GLU   A CD   1 
ATOM   718  O  OE1  . GLU   A 1 113 ? 6.56700   6.27900   11.37900  1.000 22.49295  ?  265 GLU   A OE1  1 
ATOM   719  O  OE2  . GLU   A 1 113 ? 6.12000   7.57900   13.09400  1.000 18.24614  ?  265 GLU   A OE2  1 
ATOM   720  N  N    . VAL   A 1 114 ? 9.82300   2.07000   13.17500  1.000 14.57738  ?  266 VAL   A N    1 
ATOM   721  C  CA   . VAL   A 1 114 ? 10.61800  1.03200   12.52200  1.000 13.23809  ?  266 VAL   A CA   1 
ATOM   722  C  C    . VAL   A 1 114 ? 10.60800  -0.25100  13.34200  1.000 16.78169  ?  266 VAL   A C    1 
ATOM   723  O  O    . VAL   A 1 114 ? 10.58000  -1.35700  12.78900  1.000 18.96071  ?  266 VAL   A O    1 
ATOM   724  C  CB   . VAL   A 1 114 ? 12.05300  1.53200   12.27600  1.000 15.38824  ?  266 VAL   A CB   1 
ATOM   725  C  CG1  . VAL   A 1 114 ? 12.86800  0.46700   11.54300  1.000 11.30319  ?  266 VAL   A CG1  1 
ATOM   726  C  CG2  . VAL   A 1 114 ? 12.02500  2.82400   11.47700  1.000 16.13993  ?  266 VAL   A CG2  1 
ATOM   727  N  N    . ILE   A 1 115 ? 10.63500  -0.12900  14.67100  1.000 13.04999  ?  267 ILE   A N    1 
ATOM   728  C  CA   . ILE   A 1 115 ? 10.56500  -1.31300  15.52600  1.000 13.02932  ?  267 ILE   A CA   1 
ATOM   729  C  C    . ILE   A 1 115 ? 9.25200   -2.05800  15.30600  1.000 13.47028  ?  267 ILE   A C    1 
ATOM   730  O  O    . ILE   A 1 115 ? 9.22600   -3.29300  15.24100  1.000 18.08710  ?  267 ILE   A O    1 
ATOM   731  C  CB   . ILE   A 1 115 ? 10.75800  -0.91500  17.00200  1.000 17.82149  ?  267 ILE   A CB   1 
ATOM   732  C  CG1  . ILE   A 1 115 ? 12.21500  -0.51800  17.25300  1.000 19.69196  ?  267 ILE   A CG1  1 
ATOM   733  C  CG2  . ILE   A 1 115 ? 10.36200  -2.05400  17.92500  1.000 17.81521  ?  267 ILE   A CG2  1 
ATOM   734  C  CD1  . ILE   A 1 115 ? 12.44000  0.18700   18.57500  1.000 24.44695  ?  267 ILE   A CD1  1 
ATOM   735  N  N    . MET   A 1 116 ? 8.14200   -1.32300  15.18100  1.000 17.86064  ?  268 MET   A N    1 
ATOM   736  C  CA   . MET   A 1 116 ? 6.86300   -1.96900  14.89700  1.000 14.38760  ?  268 MET   A CA   1 
ATOM   737  C  C    . MET   A 1 116 ? 6.88000   -2.65100  13.53100  1.000 21.42040  ?  268 MET   A C    1 
ATOM   738  O  O    . MET   A 1 116 ? 6.37800   -3.77300  13.38400  1.000 19.38114  ?  268 MET   A O    1 
ATOM   739  C  CB   . MET   A 1 116 ? 5.72200   -0.95100  14.98800  1.000 14.53340  ?  268 MET   A CB   1 
ATOM   740  C  CG   . MET   A 1 116 ? 5.45800   -0.45000  16.40900  1.000 18.67778  ?  268 MET   A CG   1 
ATOM   741  S  SD   . MET   A 1 116 ? 4.21500   0.86100   16.50500  1.000 23.69956  ?  268 MET   A SD   1 
ATOM   742  C  CE   . MET   A 1 116 ? 4.08200   1.07400   18.27800  1.000 20.62326  ?  268 MET   A CE   1 
ATOM   743  N  N    . LEU   A 1 117 ? 7.46000   -1.99800  12.52200  1.000 16.10404  ?  269 LEU   A N    1 
ATOM   744  C  CA   . LEU   A 1 117 ? 7.58100   -2.62700  11.20800  1.000 15.36078  ?  269 LEU   A CA   1 
ATOM   745  C  C    . LEU   A 1 117 ? 8.45900   -3.87100  11.27900  1.000 15.37587  ?  269 LEU   A C    1 
ATOM   746  O  O    . LEU   A 1 117 ? 8.08300   -4.94500  10.79500  1.000 21.86071  ?  269 LEU   A O    1 
ATOM   747  C  CB   . LEU   A 1 117 ? 8.15400   -1.63500  10.19400  1.000 19.25830  ?  269 LEU   A CB   1 
ATOM   748  C  CG   . LEU   A 1 117 ? 7.20700   -0.60600  9.58000   1.000 24.60262  ?  269 LEU   A CG   1 
ATOM   749  C  CD1  . LEU   A 1 117 ? 7.98400   0.36500   8.69800   1.000 19.06028  ?  269 LEU   A CD1  1 
ATOM   750  C  CD2  . LEU   A 1 117 ? 6.10100   -1.28600  8.78900   1.000 23.43628  ?  269 LEU   A CD2  1 
ATOM   751  N  N    . ARG   A 1 118 ? 9.64100   -3.73800  11.88100  1.000 15.09208  ?  270 ARG   A N    1 
ATOM   752  C  CA   . ARG   A 1 118 ? 10.58100  -4.85200  11.94400  1.000 19.68131  ?  270 ARG   A CA   1 
ATOM   753  C  C    . ARG   A 1 118 ? 9.99600   -6.04100  12.69600  1.000 24.87776  ?  270 ARG   A C    1 
ATOM   754  O  O    . ARG   A 1 118 ? 10.24400  -7.19700  12.33200  1.000 23.31519  ?  270 ARG   A O    1 
ATOM   755  C  CB   . ARG   A 1 118 ? 11.87400  -4.38200  12.59900  1.000 24.47781  ?  270 ARG   A CB   1 
ATOM   756  C  CG   . ARG   A 1 118 ? 12.75900  -5.48400  13.10400  1.000 43.43641  ?  270 ARG   A CG   1 
ATOM   757  C  CD   . ARG   A 1 118 ? 13.99900  -4.87400  13.70100  1.000 47.68884  ?  270 ARG   A CD   1 
ATOM   758  N  NE   . ARG   A 1 118 ? 14.48500  -3.75500  12.91000  1.000 55.47279  ?  270 ARG   A NE   1 
ATOM   759  C  CZ   . ARG   A 1 118 ? 15.66000  -3.74300  12.29400  1.000 43.51854  ?  270 ARG   A CZ   1 
ATOM   760  N  NH1  . ARG   A 1 118 ? 16.02600  -2.68400  11.58600  1.000 38.89597  ?  270 ARG   A NH1  1 
ATOM   761  N  NH2  . ARG   A 1 118 ? 16.46700  -4.79400  12.38500  1.000 37.21592  ?  270 ARG   A NH2  1 
ATOM   762  N  N    . SER   A 1 119 ? 9.21400   -5.77800  13.74800  1.000 20.25508  ?  271 SER   A N    1 
ATOM   763  C  CA   . SER   A 1 119 ? 8.61600   -6.85900  14.52400  1.000 21.25369  ?  271 SER   A CA   1 
ATOM   764  C  C    . SER   A 1 119 ? 7.64900   -7.69900  13.70200  1.000 22.60527  ?  271 SER   A C    1 
ATOM   765  O  O    . SER   A 1 119 ? 7.42200   -8.86600  14.04100  1.000 28.65554  ?  271 SER   A O    1 
ATOM   766  C  CB   . SER   A 1 119 ? 7.88600   -6.29900  15.74700  1.000 17.86300  ?  271 SER   A CB   1 
ATOM   767  O  OG   . SER   A 1 119 ? 6.60400   -5.80200  15.39600  1.000 16.81252  ?  271 SER   A OG   1 
ATOM   768  N  N    . ASN   A 1 120 ? 7.08200   -7.14100  12.62800  1.000 15.93928  ?  272 ASN   A N    1 
ATOM   769  C  CA   . ASN   A 1 120 ? 6.10900   -7.88300  11.83100  1.000 17.30792  ?  272 ASN   A CA   1 
ATOM   770  C  C    . ASN   A 1 120 ? 6.70200   -9.14400  11.21700  1.000 24.17411  ?  272 ASN   A C    1 
ATOM   771  O  O    . ASN   A 1 120 ? 5.95000   -10.06300 10.87500  1.000 24.33413  ?  272 ASN   A O    1 
ATOM   772  C  CB   . ASN   A 1 120 ? 5.53900   -6.98800  10.73100  1.000 22.60748  ?  272 ASN   A CB   1 
ATOM   773  C  CG   . ASN   A 1 120 ? 4.32800   -7.59900  10.05100  1.000 24.46992  ?  272 ASN   A CG   1 
ATOM   774  O  OD1  . ASN   A 1 120 ? 4.40600   -8.05700  8.91300   1.000 24.64703  ?  272 ASN   A OD1  1 
ATOM   775  N  ND2  . ASN   A 1 120 ? 3.20000   -7.61000  10.74900  1.000 22.67150  ?  272 ASN   A ND2  1 
ATOM   776  N  N    . GLN   A 1 121 ? 8.02900   -9.21000  11.07700  1.000 26.63611  ?  273 GLN   A N    1 
ATOM   777  C  CA   . GLN   A 1 121 ? 8.66300   -10.38900 10.49600  1.000 33.05494  ?  273 GLN   A CA   1 
ATOM   778  C  C    . GLN   A 1 121 ? 8.37800   -11.64100 11.31900  1.000 39.08165  ?  273 GLN   A C    1 
ATOM   779  O  O    . GLN   A 1 121 ? 8.17700   -12.72500 10.76000  1.000 40.93308  ?  273 GLN   A O    1 
ATOM   780  C  CB   . GLN   A 1 121 ? 10.17200  -10.16200 10.36900  1.000 27.45881  ?  273 GLN   A CB   1 
ATOM   781  C  CG   . GLN   A 1 121 ? 10.57000  -9.22200  9.23500   1.000 35.47474  ?  273 GLN   A CG   1 
ATOM   782  C  CD   . GLN   A 1 121 ? 11.99900  -8.71700  9.35600   1.000 59.79390  ?  273 GLN   A CD   1 
ATOM   783  O  OE1  . GLN   A 1 121 ? 12.23900  -7.58900  9.79400   1.000 40.09616  ?  273 GLN   A OE1  1 
ATOM   784  N  NE2  . GLN   A 1 121 ? 12.95600  -9.55100  8.96300   1.000 45.79420  ?  273 GLN   A NE2  1 
ATOM   785  N  N    . SER   A 1 122 ? 8.35000   -11.51300 12.64600  1.000 30.37286  ?  274 SER   A N    1 
ATOM   786  C  CA   . SER   A 1 122 ? 8.15200   -12.64800 13.54000  1.000 28.83405  ?  274 SER   A CA   1 
ATOM   787  C  C    . SER   A 1 122 ? 6.72400   -12.74900 14.06000  1.000 33.42097  ?  274 SER   A C    1 
ATOM   788  O  O    . SER   A 1 122 ? 6.44800   -13.58500 14.92700  1.000 37.77353  ?  274 SER   A O    1 
ATOM   789  C  CB   . SER   A 1 122 ? 9.12800   -12.56900 14.71500  1.000 41.68148  ?  274 SER   A CB   1 
ATOM   790  O  OG   . SER   A 1 122 ? 8.80600   -11.48700 15.56900  1.000 42.04820  ?  274 SER   A OG   1 
ATOM   791  N  N    . PHE   A 1 123 ? 5.81600   -11.92200 13.54900  1.000 29.01786  ?  275 PHE   A N    1 
ATOM   792  C  CA   . PHE   A 1 123 ? 4.42200   -11.94600 13.96800  1.000 26.31285  ?  275 PHE   A CA   1 
ATOM   793  C  C    . PHE   A 1 123 ? 3.66900   -13.05200 13.23700  1.000 34.13638  ?  275 PHE   A C    1 
ATOM   794  O  O    . PHE   A 1 123 ? 3.86500   -13.26400 12.03800  1.000 26.29881  ?  275 PHE   A O    1 
ATOM   795  C  CB   . PHE   A 1 123 ? 3.77900   -10.58700 13.68300  1.000 29.06139  ?  275 PHE   A CB   1 
ATOM   796  C  CG   . PHE   A 1 123 ? 2.35000   -10.47800 14.12500  1.000 30.70642  ?  275 PHE   A CG   1 
ATOM   797  C  CD1  . PHE   A 1 123 ? 2.03900   -10.27300 15.45900  1.000 26.26660  ?  275 PHE   A CD1  1 
ATOM   798  C  CD2  . PHE   A 1 123 ? 1.31700   -10.56400 13.20500  1.000 27.38466  ?  275 PHE   A CD2  1 
ATOM   799  C  CE1  . PHE   A 1 123 ? 0.72300   -10.16400 15.87200  1.000 23.04415  ?  275 PHE   A CE1  1 
ATOM   800  C  CE2  . PHE   A 1 123 ? -0.00400  -10.45700 13.61000  1.000 31.82182  ?  275 PHE   A CE2  1 
ATOM   801  C  CZ   . PHE   A 1 123 ? -0.30100  -10.25600 14.94600  1.000 30.32940  ?  275 PHE   A CZ   1 
ATOM   802  N  N    . THR   A 1 124 ? 2.80800   -13.76600 13.96300  1.000 33.00173  ?  276 THR   A N    1 
ATOM   803  C  CA   . THR   A 1 124 ? 2.00800   -14.83300 13.36900  1.000 40.58366  ?  276 THR   A CA   1 
ATOM   804  C  C    . THR   A 1 124 ? 0.53800   -14.61100 13.69000  1.000 40.86853  ?  276 THR   A C    1 
ATOM   805  O  O    . THR   A 1 124 ? 0.18500   -14.30500 14.83500  1.000 38.43788  ?  276 THR   A O    1 
ATOM   806  C  CB   . THR   A 1 124 ? 2.45400   -16.22000 13.85000  1.000 36.27767  ?  276 THR   A CB   1 
ATOM   807  O  OG1  . THR   A 1 124 ? 1.46300   -17.19500 13.49500  1.000 55.97952  ?  276 THR   A OG1  1 
ATOM   808  C  CG2  . THR   A 1 124 ? 2.66200   -16.23400 15.35800  1.000 43.05380  ?  276 THR   A CG2  1 
ATOM   809  N  N    . MET   A 1 125 ? -0.31400  -14.78600 12.67700  1.000 41.46509  ?  277 MET   A N    1 
ATOM   810  C  CA   . MET   A 1 125 ? -1.73900  -14.50900 12.79400  1.000 46.03592  ?  277 MET   A CA   1 
ATOM   811  C  C    . MET   A 1 125 ? -2.54100  -15.66500 13.37100  1.000 41.13786  ?  277 MET   A C    1 
ATOM   812  O  O    . MET   A 1 125 ? -3.75200  -15.51300 13.56300  1.000 53.86112  ?  277 MET   A O    1 
ATOM   813  C  CB   . MET   A 1 125 ? -2.31300  -14.12100 11.43200  1.000 58.56627  ?  277 MET   A CB   1 
ATOM   814  C  CG   . MET   A 1 125 ? -1.77500  -12.81300 10.88100  1.000 42.03306  ?  277 MET   A CG   1 
ATOM   815  S  SD   . MET   A 1 125 ? -2.51800  -12.40400 9.29400   1.000 57.65439  ?  277 MET   A SD   1 
ATOM   816  C  CE   . MET   A 1 125 ? -4.25000  -12.46100 9.73500   1.000 48.72446  ?  277 MET   A CE   1 
ATOM   817  N  N    . ASP   A 1 126 ? -1.91600  -16.81400 13.63900  1.000 40.63566  ?  278 ASP   A N    1 
ATOM   818  C  CA   . ASP   A 1 126 ? -2.60900  -17.88100 14.35800  1.000 54.50718  ?  278 ASP   A CA   1 
ATOM   819  C  C    . ASP   A 1 126 ? -3.19100  -17.35100 15.65800  1.000 62.58160  ?  278 ASP   A C    1 
ATOM   820  O  O    . ASP   A 1 126 ? -4.38500  -17.50700 15.94000  1.000 57.59377  ?  278 ASP   A O    1 
ATOM   821  C  CB   . ASP   A 1 126 ? -1.65000  -19.02700 14.67600  1.000 57.00214  ?  278 ASP   A CB   1 
ATOM   822  C  CG   . ASP   A 1 126 ? -0.79100  -19.42300 13.50500  1.000 68.34765  ?  278 ASP   A CG   1 
ATOM   823  O  OD1  . ASP   A 1 126 ? -1.26600  -19.34100 12.35500  1.000 61.63137  ?  278 ASP   A OD1  1 
ATOM   824  O  OD2  . ASP   A 1 126 ? 0.37500   -19.80600 13.75100  1.000 59.49830  ?  278 ASP   A OD2  1 
ATOM   825  N  N    . ASP   A 1 127 ? -2.34400  -16.69100 16.45500  1.000 57.50616  ?  279 ASP   A N    1 
ATOM   826  C  CA   . ASP   A 1 127 ? -2.64200  -16.38400 17.84600  1.000 54.27585  ?  279 ASP   A CA   1 
ATOM   827  C  C    . ASP   A 1 127 ? -2.25000  -14.95800 18.22100  1.000 54.36277  ?  279 ASP   A C    1 
ATOM   828  O  O    . ASP   A 1 127 ? -2.15600  -14.64700 19.41400  1.000 42.23465  ?  279 ASP   A O    1 
ATOM   829  C  CB   . ASP   A 1 127 ? -1.92400  -17.39100 18.74400  1.000 44.57277  ?  279 ASP   A CB   1 
ATOM   830  C  CG   . ASP   A 1 127 ? -0.47000  -17.58300 18.34300  1.000 57.74007  ?  279 ASP   A CG   1 
ATOM   831  O  OD1  . ASP   A 1 127 ? 0.19700   -18.47100 18.91200  1.000 65.18999  ?  279 ASP   A OD1  1 
ATOM   832  O  OD2  . ASP   A 1 127 ? 0.00800   -16.84400 17.45500  1.000 55.46520  ?  279 ASP   A OD2  1 
ATOM   833  N  N    . MET   A 1 128 ? -2.02500  -14.09000 17.23400  1.000 50.31323  ?  280 MET   A N    1 
ATOM   834  C  CA   . MET   A 1 128 ? -1.68600  -12.68400 17.45400  1.000 44.31213  ?  280 MET   A CA   1 
ATOM   835  C  C    . MET   A 1 128 ? -0.47900  -12.54300 18.38200  1.000 35.51694  ?  280 MET   A C    1 
ATOM   836  O  O    . MET   A 1 128 ? -0.53900  -11.90300 19.43300  1.000 48.74792  ?  280 MET   A O    1 
ATOM   837  C  CB   . MET   A 1 128 ? -2.88300  -11.91000 18.01600  1.000 43.05558  ?  280 MET   A CB   1 
ATOM   838  C  CG   . MET   A 1 128 ? -4.23500  -12.24200 17.39800  1.000 57.90462  ?  280 MET   A CG   1 
ATOM   839  S  SD   . MET   A 1 128 ? -4.57200  -11.35600 15.86300  1.000 57.86383  ?  280 MET   A SD   1 
ATOM   840  C  CE   . MET   A 1 128 ? -3.91600  -12.49100 14.65000  1.000 51.37543  ?  280 MET   A CE   1 
ATOM   841  N  N    . SER   A 1 129 ? 0.63700   -13.14200 17.97000  1.000 30.22622  ?  281 SER   A N    1 
ATOM   842  C  CA   . SER   A 1 129 ? 1.81700   -13.19600 18.81800  1.000 37.17088  ?  281 SER   A CA   1 
ATOM   843  C  C    . SER   A 1 129 ? 3.08200   -13.02100 17.98800  1.000 38.75995  ?  281 SER   A C    1 
ATOM   844  O  O    . SER   A 1 129 ? 3.06500   -13.07700 16.75600  1.000 34.35148  ?  281 SER   A O    1 
ATOM   845  C  CB   . SER   A 1 129 ? 1.86300   -14.51400 19.58900  1.000 36.72872  ?  281 SER   A CB   1 
ATOM   846  O  OG   . SER   A 1 129 ? 2.08400   -15.56700 18.67800  1.000 42.50780  ?  281 SER   A OG   1 
ATOM   847  N  N    . TRP   A 1 130 ? 4.19600   -12.81800 18.69300  1.000 29.61879  ?  282 TRP   A N    1 
ATOM   848  C  CA   . TRP   A 1 130 ? 5.51800   -12.63300 18.10000  1.000 29.80235  ?  282 TRP   A CA   1 
ATOM   849  C  C    . TRP   A 1 130 ? 6.40700   -13.78900 18.55400  1.000 36.26679  ?  282 TRP   A C    1 
ATOM   850  O  O    . TRP   A 1 130 ? 6.79200   -13.84700 19.72600  1.000 40.31302  ?  282 TRP   A O    1 
ATOM   851  C  CB   . TRP   A 1 130 ? 6.10600   -11.28100 18.52900  1.000 27.71791  ?  282 TRP   A CB   1 
ATOM   852  C  CG   . TRP   A 1 130 ? 5.40500   -10.04100 17.98000  1.000 24.02025  ?  282 TRP   A CG   1 
ATOM   853  C  CD1  . TRP   A 1 130 ? 5.72200   -9.35900  16.83700  1.000 21.26920  ?  282 TRP   A CD1  1 
ATOM   854  C  CD2  . TRP   A 1 130 ? 4.30200   -9.33300  18.57100  1.000 24.83837  ?  282 TRP   A CD2  1 
ATOM   855  N  NE1  . TRP   A 1 130 ? 4.88000   -8.28400  16.67600  1.000 22.60334  ?  282 TRP   A NE1  1 
ATOM   856  C  CE2  . TRP   A 1 130 ? 4.00000   -8.24500  17.72600  1.000 20.53204  ?  282 TRP   A CE2  1 
ATOM   857  C  CE3  . TRP   A 1 130 ? 3.53600   -9.52000  19.72600  1.000 26.99625  ?  282 TRP   A CE3  1 
ATOM   858  C  CZ2  . TRP   A 1 130 ? 2.96500   -7.34900  18.00100  1.000 29.61910  ?  282 TRP   A CZ2  1 
ATOM   859  C  CZ3  . TRP   A 1 130 ? 2.51000   -8.62800  19.99800  1.000 20.31705  ?  282 TRP   A CZ3  1 
ATOM   860  C  CH2  . TRP   A 1 130 ? 2.23500   -7.55700  19.14100  1.000 31.70582  ?  282 TRP   A CH2  1 
ATOM   861  N  N    . ASP   A 1 131 ? 6.74000   -14.71200 17.64800  1.000 45.01786  ?  283 ASP   A N    1 
ATOM   862  C  CA   . ASP   A 1 131 ? 7.54800   -15.87900 18.01100  1.000 51.93789  ?  283 ASP   A CA   1 
ATOM   863  C  C    . ASP   A 1 131 ? 9.00800   -15.66100 17.64000  1.000 57.15716  ?  283 ASP   A C    1 
ATOM   864  O  O    . ASP   A 1 131 ? 9.32000   -15.30300 16.49900  1.000 51.04779  ?  283 ASP   A O    1 
ATOM   865  C  CB   . ASP   A 1 131 ? 7.04700   -17.16000 17.34100  1.000 70.03130  ?  283 ASP   A CB   1 
ATOM   866  C  CG   . ASP   A 1 131 ? 7.77100   -18.41300 17.84900  1.000 79.01228  ?  283 ASP   A CG   1 
ATOM   867  O  OD1  . ASP   A 1 131 ? 7.07100   -19.37200 18.23800  1.000 81.87262  ?  283 ASP   A OD1  1 
ATOM   868  O  OD2  . ASP   A 1 131 ? 9.02800   -18.46200 17.85100  1.000 70.17261  ?  283 ASP   A OD2  1 
ATOM   869  N  N    . CYS   A 1 132 ? 9.89700   -15.93900 18.58700  1.000 51.76458  ?  284 CYS   A N    1 
ATOM   870  C  CA   . CYS   A 1 132 ? 11.31800  -15.69700 18.40200  1.000 51.01708  ?  284 CYS   A CA   1 
ATOM   871  C  C    . CYS   A 1 132 ? 12.15400  -16.89200 18.81700  1.000 57.05240  ?  284 CYS   A C    1 
ATOM   872  O  O    . CYS   A 1 132 ? 13.19800  -16.74500 19.45600  1.000 67.24450  ?  284 CYS   A O    1 
ATOM   873  C  CB   . CYS   A 1 132 ? 11.75200  -14.45100 19.15800  1.000 54.62736  ?  284 CYS   A CB   1 
ATOM   874  S  SG   . CYS   A 1 132 ? 10.81200  -13.07900 18.58700  1.000 57.52658  ?  284 CYS   A SG   1 
ATOM   875  N  N    . GLY   A 1 133 ? 11.73100  -18.09400 18.43800  1.000 65.43132  ?  285 GLY   A N    1 
ATOM   876  C  CA   . GLY   A 1 133 ? 12.56700  -19.26600 18.53400  1.000 82.62213  ?  285 GLY   A CA   1 
ATOM   877  C  C    . GLY   A 1 133 ? 12.30600  -20.15400 19.73400  1.000 85.37521  ?  285 GLY   A C    1 
ATOM   878  O  O    . GLY   A 1 133 ? 12.64800  -21.34000 19.69000  1.000 88.19410  ?  285 GLY   A O    1 
ATOM   879  N  N    . SER   A 1 134 ? 11.65700  -19.61000 20.75100  1.000 81.10855  ?  286 SER   A N    1 
ATOM   880  C  CA   . SER   A 1 134 ? 11.43200  -20.39500 21.98100  1.000 72.74786  ?  286 SER   A CA   1 
ATOM   881  C  C    . SER   A 1 134 ? 10.15900  -19.89700 22.65100  1.000 74.12497  ?  286 SER   A C    1 
ATOM   882  O  O    . SER   A 1 134 ? 9.66200   -18.83600 22.28700  1.000 67.10082  ?  286 SER   A O    1 
ATOM   883  C  CB   . SER   A 1 134 ? 12.60600  -20.24700 22.87500  1.000 70.45902  ?  286 SER   A CB   1 
ATOM   884  O  OG   . SER   A 1 134 ? 13.79700  -20.25400 22.11400  1.000 77.70987  ?  286 SER   A OG   1 
ATOM   885  N  N    . GLN   A 1 135 ? 9.65400   -20.66500 23.60000  1.000 80.59327  ?  287 GLN   A N    1 
ATOM   886  C  CA   . GLN   A 1 135 ? 8.42300   -20.27800 24.28100  1.000 80.99349  ?  287 GLN   A CA   1 
ATOM   887  C  C    . GLN   A 1 135 ? 8.65700   -19.10000 25.21700  1.000 74.66032  ?  287 GLN   A C    1 
ATOM   888  O  O    . GLN   A 1 135 ? 7.78400   -18.23700 25.36300  1.000 60.70912  ?  287 GLN   A O    1 
ATOM   889  C  CB   . GLN   A 1 135 ? 7.84600   -21.46900 25.04400  1.000 81.56055  ?  287 GLN   A CB   1 
ATOM   890  C  CG   . GLN   A 1 135 ? 8.01100   -22.82900 24.35800  1.000 85.01720  ?  287 GLN   A CG   1 
ATOM   891  C  CD   . GLN   A 1 135 ? 7.38100   -22.92200 22.96600  1.000 90.32530  ?  287 GLN   A CD   1 
ATOM   892  O  OE1  . GLN   A 1 135 ? 6.76900   -21.97700 22.46500  1.000 86.13918  ?  287 GLN   A OE1  1 
ATOM   893  N  NE2  . GLN   A 1 135 ? 7.53400   -24.08300 22.33800  1.000 86.67214  ?  287 GLN   A NE2  1 
ATOM   894  N  N    . ASP   A 1 136 ? 9.82300   -19.05600 25.86700  1.000 76.05183  ?  288 ASP   A N    1 
ATOM   895  C  CA   . ASP   A 1 136 ? 10.19700  -17.88100 26.64800  1.000 75.43182  ?  288 ASP   A CA   1 
ATOM   896  C  C    . ASP   A 1 136 ? 10.10100  -16.62200 25.80300  1.000 67.06801  ?  288 ASP   A C    1 
ATOM   897  O  O    . ASP   A 1 136 ? 9.55900   -15.59800 26.24000  1.000 51.61450  ?  288 ASP   A O    1 
ATOM   898  C  CB   . ASP   A 1 136 ? 11.61700  -18.04900 27.19600  1.000 69.40036  ?  288 ASP   A CB   1 
ATOM   899  C  CG   . ASP   A 1 136 ? 11.72800  -19.16700 28.21200  1.000 76.44143  ?  288 ASP   A CG   1 
ATOM   900  O  OD1  . ASP   A 1 136 ? 12.86900  -19.56000 28.53200  1.000 79.03206  ?  288 ASP   A OD1  1 
ATOM   901  O  OD2  . ASP   A 1 136 ? 10.68300  -19.64800 28.69400  1.000 77.38832  ?  288 ASP   A OD2  1 
ATOM   902  N  N    . TYR   A 1 137 ? 10.60200  -16.69500 24.57100  1.000 64.34235  ?  289 TYR   A N    1 
ATOM   903  C  CA   . TYR   A 1 137 ? 10.68500  -15.54500 23.66900  1.000 57.80262  ?  289 TYR   A CA   1 
ATOM   904  C  C    . TYR   A 1 137 ? 9.55200   -15.52400 22.64600  1.000 58.58314  ?  289 TYR   A C    1 
ATOM   905  O  O    . TYR   A 1 137 ? 9.76000   -15.14700 21.49300  1.000 53.99573  ?  289 TYR   A O    1 
ATOM   906  C  CB   . TYR   A 1 137 ? 12.04700  -15.53000 22.97800  1.000 53.57686  ?  289 TYR   A CB   1 
ATOM   907  C  CG   . TYR   A 1 137 ? 13.19000  -15.63100 23.95300  1.000 53.49271  ?  289 TYR   A CG   1 
ATOM   908  C  CD1  . TYR   A 1 137 ? 14.22300  -16.54000 23.75900  1.000 59.19444  ?  289 TYR   A CD1  1 
ATOM   909  C  CD2  . TYR   A 1 137 ? 13.23200  -14.81900 25.08100  1.000 53.46106  ?  289 TYR   A CD2  1 
ATOM   910  C  CE1  . TYR   A 1 137 ? 15.27100  -16.63100 24.66100  1.000 56.47975  ?  289 TYR   A CE1  1 
ATOM   911  C  CE2  . TYR   A 1 137 ? 14.27200  -14.90600 25.98100  1.000 45.15740  ?  289 TYR   A CE2  1 
ATOM   912  C  CZ   . TYR   A 1 137 ? 15.28500  -15.81000 25.76800  1.000 54.05160  ?  289 TYR   A CZ   1 
ATOM   913  O  OH   . TYR   A 1 137 ? 16.31700  -15.89100 26.67000  1.000 51.45824  ?  289 TYR   A OH   1 
ATOM   914  N  N    . LYS   A 1 138 ? 8.34500   -15.94400 23.04800  1.000 55.73239  ?  290 LYS   A N    1 
ATOM   915  C  CA   . LYS   A 1 138 ? 7.12800   -15.71300 22.27700  1.000 58.31176  ?  290 LYS   A CA   1 
ATOM   916  C  C    . LYS   A 1 138 ? 6.28700   -14.70000 23.02500  1.000 44.57311  ?  290 LYS   A C    1 
ATOM   917  O  O    . LYS   A 1 138 ? 5.90700   -14.94600 24.18000  1.000 50.69816  ?  290 LYS   A O    1 
ATOM   918  C  CB   . LYS   A 1 138 ? 6.33700   -17.00500 22.06700  1.000 59.29264  ?  290 LYS   A CB   1 
ATOM   919  C  CG   . LYS   A 1 138 ? 5.12900   -16.80500 21.14200  1.000 53.96357  ?  290 LYS   A CG   1 
ATOM   920  C  CD   . LYS   A 1 138 ? 5.19600   -17.81400 20.01500  1.000 71.21050  ?  290 LYS   A CD   1 
ATOM   921  C  CE   . LYS   A 1 138 ? 3.99100   -17.74700 19.10500  1.000 76.71436  ?  290 LYS   A CE   1 
ATOM   922  N  NZ   . LYS   A 1 138 ? 3.80300   -19.00100 18.34800  1.000 82.24279  ?  290 LYS   A NZ   1 
ATOM   923  N  N    . TYR   A 1 139 ? 5.95400   -13.59500 22.36500  1.000 36.67081  ?  291 TYR   A N    1 
ATOM   924  C  CA   . TYR   A 1 139 ? 5.31300   -12.46700 23.02600  1.000 29.86122  ?  291 TYR   A CA   1 
ATOM   925  C  C    . TYR   A 1 139 ? 3.87300   -12.32700 22.56200  1.000 31.43091  ?  291 TYR   A C    1 
ATOM   926  O  O    . TYR   A 1 139 ? 3.60000   -12.40100 21.36400  1.000 36.48458  ?  291 TYR   A O    1 
ATOM   927  C  CB   . TYR   A 1 139 ? 6.10400   -11.18800 22.76400  1.000 31.74336  ?  291 TYR   A CB   1 
ATOM   928  C  CG   . TYR   A 1 139 ? 7.58500   -11.33900 23.03100  1.000 37.29961  ?  291 TYR   A CG   1 
ATOM   929  C  CD1  . TYR   A 1 139 ? 8.50100   -11.29200 21.98700  1.000 29.52281  ?  291 TYR   A CD1  1 
ATOM   930  C  CD2  . TYR   A 1 139 ? 8.06800   -11.52100 24.31800  1.000 35.37849  ?  291 TYR   A CD2  1 
ATOM   931  C  CE1  . TYR   A 1 139 ? 9.85100   -11.43800 22.21700  1.000 42.88376  ?  291 TYR   A CE1  1 
ATOM   932  C  CE2  . TYR   A 1 139 ? 9.42200   -11.66300 24.56000  1.000 31.33703  ?  291 TYR   A CE2  1 
ATOM   933  C  CZ   . TYR   A 1 139 ? 10.30900  -11.62100 23.50600  1.000 33.11456  ?  291 TYR   A CZ   1 
ATOM   934  O  OH   . TYR   A 1 139 ? 11.65400  -11.76600 23.75700  1.000 28.11142  ?  291 TYR   A OH   1 
ATOM   935  N  N    . ASP   A 1 140 ? 2.96200   -12.12300 23.50600  1.000 28.15311  ?  292 ASP   A N    1 
ATOM   936  C  CA   . ASP   A 1 140 ? 1.56400   -11.88900 23.18700  1.000 31.46550  ?  292 ASP   A CA   1 
ATOM   937  C  C    . ASP   A 1 140 ? 1.11900   -10.54600 23.75900  1.000 33.94667  ?  292 ASP   A C    1 
ATOM   938  O  O    . ASP   A 1 140 ? 1.91700   -9.78100  24.31000  1.000 37.46083  ?  292 ASP   A O    1 
ATOM   939  C  CB   . ASP   A 1 140 ? 0.68400   -13.04000 23.69000  1.000 33.64296  ?  292 ASP   A CB   1 
ATOM   940  C  CG   . ASP   A 1 140 ? 0.89200   -13.34800 25.16100  1.000 47.67752  ?  292 ASP   A CG   1 
ATOM   941  O  OD1  . ASP   A 1 140 ? 0.37200   -14.38800 25.62200  1.000 55.34021  ?  292 ASP   A OD1  1 
ATOM   942  O  OD2  . ASP   A 1 140 ? 1.56800   -12.56500 25.85400  1.000 40.63090  ?  292 ASP   A OD2  1 
ATOM   943  N  N    . VAL   A 1 141 ? -0.17400  -10.28200 23.62300  1.000 34.22214  ?  293 VAL   A N    1 
ATOM   944  C  CA   . VAL   A 1 141 ? -0.84400  -9.03800  24.09900  1.000 34.06334  ?  293 VAL   A CA   1 
ATOM   945  C  C    . VAL   A 1 141 ? -0.59800  -8.87700  25.59800  1.000 38.25452  ?  293 VAL   A C    1 
ATOM   946  O  O    . VAL   A 1 141 ? -0.51000  -7.74700  26.04200  1.000 32.14358  ?  293 VAL   A O    1 
ATOM   947  C  CB   . VAL   A 1 141 ? -2.35800  -9.09600  23.81400  1.000 43.81178  ?  293 VAL   A CB   1 
ATOM   948  C  CG1  . VAL   A 1 141 ? -2.88600  -10.50100 24.00700  1.000 47.79090  ?  293 VAL   A CG1  1 
ATOM   949  C  CG2  . VAL   A 1 141 ? -3.15700  -8.19100  24.72600  1.000 48.98827  ?  293 VAL   A CG2  1 
ATOM   950  N  N    . THR   A 1 142 ? -0.51700  -9.98200  26.33100  1.000 33.00856  ?  294 THR   A N    1 
ATOM   951  C  CA   . THR   A 1 142 ? -0.35000  -9.91700  27.77900  1.000 43.35394  ?  294 THR   A CA   1 
ATOM   952  C  C    . THR   A 1 142 ? 1.03700   -9.40900  28.15500  1.000 36.02800  ?  294 THR   A C    1 
ATOM   953  O  O    . THR   A 1 142 ? 1.18600   -8.64500  29.11800  1.000 31.55633  ?  294 THR   A O    1 
ATOM   954  C  CB   . THR   A 1 142 ? -0.60400  -11.29400 28.39600  1.000 41.77892  ?  294 THR   A CB   1 
ATOM   955  O  OG1  . THR   A 1 142 ? -1.94400  -11.71100 28.10500  1.000 50.74158  ?  294 THR   A OG1  1 
ATOM   956  C  CG2  . THR   A 1 142 ? -0.41500  -11.25200 29.90300  1.000 47.92895  ?  294 THR   A CG2  1 
ATOM   957  N  N    . ASP   A 1 143 ? 2.06500   -9.82000  27.40500  1.000 31.80720  ?  295 ASP   A N    1 
ATOM   958  C  CA   . ASP   A 1 143 ? 3.42200   -9.36900  27.69700  1.000 27.76433  ?  295 ASP   A CA   1 
ATOM   959  C  C    . ASP   A 1 143 ? 3.55400   -7.86400  27.51200  1.000 22.16728  ?  295 ASP   A C    1 
ATOM   960  O  O    . ASP   A 1 143 ? 4.22100   -7.18900  28.30600  1.000 22.43361  ?  295 ASP   A O    1 
ATOM   961  C  CB   . ASP   A 1 143 ? 4.42500   -10.10800 26.81100  1.000 30.53584  ?  295 ASP   A CB   1 
ATOM   962  C  CG   . ASP   A 1 143 ? 4.45200   -11.60000 27.08300  1.000 47.48826  ?  295 ASP   A CG   1 
ATOM   963  O  OD1  . ASP   A 1 143 ? 4.32800   -11.99400 28.26200  1.000 44.91965  ?  295 ASP   A OD1  1 
ATOM   964  O  OD2  . ASP   A 1 143 ? 4.59300   -12.38100 26.11900  1.000 43.46939  ?  295 ASP   A OD2  1 
ATOM   965  N  N    . VAL   A 1 144 ? 2.93400   -7.32000  26.46400  1.000 29.71518  ?  296 VAL   A N    1 
ATOM   966  C  CA   . VAL   A 1 144 ? 2.95700   -5.87600  26.26300  1.000 30.19595  ?  296 VAL   A CA   1 
ATOM   967  C  C    . VAL   A 1 144 ? 2.21100   -5.17400  27.38900  1.000 28.83062  ?  296 VAL   A C    1 
ATOM   968  O  O    . VAL   A 1 144 ? 2.61800   -4.10000  27.84800  1.000 22.79067  ?  296 VAL   A O    1 
ATOM   969  C  CB   . VAL   A 1 144 ? 2.37800   -5.51700  24.88400  1.000 28.48214  ?  296 VAL   A CB   1 
ATOM   970  C  CG1  . VAL   A 1 144 ? 2.57300   -4.03400  24.59000  1.000 22.92021  ?  296 VAL   A CG1  1 
ATOM   971  C  CG2  . VAL   A 1 144 ? 3.02200   -6.37300  23.80500  1.000 28.12077  ?  296 VAL   A CG2  1 
ATOM   972  N  N    . SER   A 1 145 ? 1.11100   -5.76800  27.85300  1.000 19.51467  ?  297 SER   A N    1 
ATOM   973  C  CA   . SER   A 1 145 ? 0.42500   -5.24500  29.03300  1.000 25.48057  ?  297 SER   A CA   1 
ATOM   974  C  C    . SER   A 1 145 ? 1.36200   -5.20400  30.23300  1.000 21.07931  ?  297 SER   A C    1 
ATOM   975  O  O    . SER   A 1 145 ? 1.41200   -4.20300  30.96400  1.000 23.58348  ?  297 SER   A O    1 
ATOM   976  C  CB   . SER   A 1 145 ? -0.80500  -6.10100  29.34800  1.000 23.63996  ?  297 SER   A CB   1 
ATOM   977  O  OG   . SER   A 1 145 ? -1.89500  -5.76200  28.51600  1.000 41.35551  ?  297 SER   A OG   1 
ATOM   978  N  N    . LYS   A 1 146 ? 2.14900   -6.26800  30.42700  1.000 21.86953  ?  298 LYS   A N    1 
ATOM   979  C  CA   . LYS   A 1 146 ? 3.05900   -6.35800  31.55900  1.000 27.59897  ?  298 LYS   A CA   1 
ATOM   980  C  C    . LYS   A 1 146 ? 4.31400   -5.51900  31.37200  1.000 28.33574  ?  298 LYS   A C    1 
ATOM   981  O  O    . LYS   A 1 146 ? 5.21500   -5.58800  32.21300  1.000 26.09872  ?  298 LYS   A O    1 
ATOM   982  C  CB   . LYS   A 1 146 ? 3.41600   -7.81900  31.80900  1.000 29.49357  ?  298 LYS   A CB   1 
ATOM   983  C  CG   . LYS   A 1 146 ? 2.22900   -8.65300  32.27100  1.000 30.35352  ?  298 LYS   A CG   1 
ATOM   984  C  CD   . LYS   A 1 146 ? 2.57100   -10.12600 32.38800  1.000 34.21795  ?  298 LYS   A CD   1 
ATOM   985  C  CE   . LYS   A 1 146 ? 1.43500   -10.89600 33.04600  1.000 58.02004  ?  298 LYS   A CE   1 
ATOM   986  N  NZ   . LYS   A 1 146 ? 1.31700   -12.29100 32.53500  1.000 57.00717  ?  298 LYS   A NZ   1 
ATOM   987  N  N    . ALA   A 1 147 ? 4.39800   -4.74700  30.28900  1.000 21.91808  ?  299 ALA   A N    1 
ATOM   988  C  CA   . ALA   A 1 147 ? 5.40300   -3.70500  30.14500  1.000 22.04292  ?  299 ALA   A CA   1 
ATOM   989  C  C    . ALA   A 1 147 ? 4.83200   -2.31900  30.41100  1.000 28.69072  ?  299 ALA   A C    1 
ATOM   990  O  O    . ALA   A 1 147 ? 5.57500   -1.33400  30.34800  1.000 25.20988  ?  299 ALA   A O    1 
ATOM   991  C  CB   . ALA   A 1 147 ? 6.02500   -3.75300  28.74500  1.000 26.76934  ?  299 ALA   A CB   1 
ATOM   992  N  N    . GLY   A 1 148 ? 3.53000   -2.22200  30.69200  1.000 22.09399  ?  300 GLY   A N    1 
ATOM   993  C  CA   . GLY   A 1 148 ? 2.91000   -0.97400  31.09200  1.000 20.27829  ?  300 GLY   A CA   1 
ATOM   994  C  C    . GLY   A 1 148 ? 1.91500   -0.38600  30.11900  1.000 29.67139  ?  300 GLY   A C    1 
ATOM   995  O  O    . GLY   A 1 148 ? 1.31800   0.65100   30.43000  1.000 26.97625  ?  300 GLY   A O    1 
ATOM   996  N  N    . HIS   A 1 149 ? 1.70600   -0.99900  28.96200  1.000 24.46149  ?  301 HIS   A N    1 
ATOM   997  C  CA   . HIS   A 1 149 ? 0.84100   -0.40600  27.95500  1.000 22.68634  ?  301 HIS   A CA   1 
ATOM   998  C  C    . HIS   A 1 149 ? -0.58300  -0.93000  28.08000  1.000 24.16772  ?  301 HIS   A C    1 
ATOM   999  O  O    . HIS   A 1 149 ? -0.81900  -2.04000  28.56400  1.000 24.08545  ?  301 HIS   A O    1 
ATOM   1000 C  CB   . HIS   A 1 149 ? 1.39800   -0.67100  26.55700  1.000 22.00456  ?  301 HIS   A CB   1 
ATOM   1001 C  CG   . HIS   A 1 149 ? 2.68300   0.04600   26.29000  1.000 27.03650  ?  301 HIS   A CG   1 
ATOM   1002 N  ND1  . HIS   A 1 149 ? 2.76700   1.42100   26.23700  1.000 21.97687  ?  301 HIS   A ND1  1 
ATOM   1003 C  CD2  . HIS   A 1 149 ? 3.94000   -0.41600  26.08600  1.000 23.11923  ?  301 HIS   A CD2  1 
ATOM   1004 C  CE1  . HIS   A 1 149 ? 4.01800   1.77500   26.00200  1.000 22.87740  ?  301 HIS   A CE1  1 
ATOM   1005 N  NE2  . HIS   A 1 149 ? 4.74900   0.67900   25.90500  1.000 22.08572  ?  301 HIS   A NE2  1 
ATOM   1006 N  N    . THR   A 1 150 ? -1.53200  -0.10300  27.65300  1.000 18.52672  ?  302 THR   A N    1 
ATOM   1007 C  CA   . THR   A 1 150 ? -2.95300  -0.41600  27.71100  1.000 26.10329  ?  302 THR   A CA   1 
ATOM   1008 C  C    . THR   A 1 150 ? -3.47900  -0.71900  26.31000  1.000 30.82286  ?  302 THR   A C    1 
ATOM   1009 O  O    . THR   A 1 150 ? -2.76100  -0.62300  25.31000  1.000 26.05882  ?  302 THR   A O    1 
ATOM   1010 C  CB   . THR   A 1 150 ? -3.73700  0.73400   28.34700  1.000 25.37395  ?  302 THR   A CB   1 
ATOM   1011 O  OG1  . THR   A 1 150 ? -3.76800  1.84900   27.44600  1.000 33.30838  ?  302 THR   A OG1  1 
ATOM   1012 C  CG2  . THR   A 1 150 ? -3.09300  1.15900   29.65600  1.000 34.00699  ?  302 THR   A CG2  1 
ATOM   1013 N  N    . LEU   A 1 151 ? -4.76600  -1.07200  26.24800  1.000 25.19655  ?  303 LEU   A N    1 
ATOM   1014 C  CA   . LEU   A 1 151 ? -5.37900  -1.50100  24.99600  1.000 20.97564  ?  303 LEU   A CA   1 
ATOM   1015 C  C    . LEU   A 1 151 ? -5.48700  -0.38400  23.97100  1.000 18.70299  ?  303 LEU   A C    1 
ATOM   1016 O  O    . LEU   A 1 151 ? -5.59700  -0.67700  22.77400  1.000 22.58235  ?  303 LEU   A O    1 
ATOM   1017 C  CB   . LEU   A 1 151 ? -6.76600  -2.08000  25.26400  1.000 25.43173  ?  303 LEU   A CB   1 
ATOM   1018 C  CG   . LEU   A 1 151 ? -6.77700  -3.36400  26.08500  1.000 32.35374  ?  303 LEU   A CG   1 
ATOM   1019 C  CD1  . LEU   A 1 151 ? -8.20500  -3.78400  26.38000  1.000 35.46893  ?  303 LEU   A CD1  1 
ATOM   1020 C  CD2  . LEU   A 1 151 ? -6.02500  -4.45200  25.34000  1.000 34.71209  ?  303 LEU   A CD2  1 
ATOM   1021 N  N    . GLU   A 1 152 ? -5.48000  0.88200   24.40400  1.000 15.92914  ?  304 GLU   A N    1 
ATOM   1022 C  CA   . GLU   A 1 152 ? -5.52800  1.97500   23.43900  1.000 30.16604  ?  304 GLU   A CA   1 
ATOM   1023 C  C    . GLU   A 1 152 ? -4.30200  1.99100   22.54000  1.000 23.48456  ?  304 GLU   A C    1 
ATOM   1024 O  O    . GLU   A 1 152 ? -4.35200  2.57200   21.45200  1.000 20.41067  ?  304 GLU   A O    1 
ATOM   1025 C  CB   . GLU   A 1 152 ? -5.67300  3.31900   24.15600  1.000 27.84157  ?  304 GLU   A CB   1 
ATOM   1026 C  CG   . GLU   A 1 152 ? -7.09800  3.59500   24.60300  1.000 45.73492  ?  304 GLU   A CG   1 
ATOM   1027 C  CD   . GLU   A 1 152 ? -7.47600  2.78300   25.82600  1.000 65.60338  ?  304 GLU   A CD   1 
ATOM   1028 O  OE1  . GLU   A 1 152 ? -6.63100  2.65100   26.73700  1.000 61.24093  ?  304 GLU   A OE1  1 
ATOM   1029 O  OE2  . GLU   A 1 152 ? -8.60500  2.25400   25.86900  1.000 71.54533  ?  304 GLU   A OE2  1 
ATOM   1030 N  N    . LEU   A 1 153 ? -3.21200  1.35400   22.96200  1.000 19.75319  ?  305 LEU   A N    1 
ATOM   1031 C  CA   . LEU   A 1 153 ? -2.07300  1.07700   22.09500  1.000 20.06215  ?  305 LEU   A CA   1 
ATOM   1032 C  C    . LEU   A 1 153 ? -2.10300  -0.33700  21.53900  1.000 24.42244  ?  305 LEU   A C    1 
ATOM   1033 O  O    . LEU   A 1 153 ? -1.85700  -0.53400  20.34500  1.000 22.26532  ?  305 LEU   A O    1 
ATOM   1034 C  CB   . LEU   A 1 153 ? -0.75500  1.29100   22.85000  1.000 18.15235  ?  305 LEU   A CB   1 
ATOM   1035 C  CG   . LEU   A 1 153 ? 0.52000   0.96400   22.06600  1.000 18.18120  ?  305 LEU   A CG   1 
ATOM   1036 C  CD1  . LEU   A 1 153 ? 0.61500   1.81600   20.81100  1.000 18.93882  ?  305 LEU   A CD1  1 
ATOM   1037 C  CD2  . LEU   A 1 153 ? 1.76600   1.14000   22.93000  1.000 21.39735  ?  305 LEU   A CD2  1 
ATOM   1038 N  N    . ILE   A 1 154 ? -2.43200  -1.32200  22.37800  1.000 20.13872  ?  306 ILE   A N    1 
ATOM   1039 C  CA   . ILE   A 1 154 ? -2.26100  -2.71700  21.99200  1.000 26.46556  ?  306 ILE   A CA   1 
ATOM   1040 C  C    . ILE   A 1 154 ? -3.28600  -3.12900  20.94000  1.000 26.71179  ?  306 ILE   A C    1 
ATOM   1041 O  O    . ILE   A 1 154 ? -2.96400  -3.87400  20.00700  1.000 26.54537  ?  306 ILE   A O    1 
ATOM   1042 C  CB   . ILE   A 1 154 ? -2.32500  -3.62000  23.23500  1.000 22.37890  ?  306 ILE   A CB   1 
ATOM   1043 C  CG1  . ILE   A 1 154 ? -1.12500  -3.34900  24.14500  1.000 22.80707  ?  306 ILE   A CG1  1 
ATOM   1044 C  CG2  . ILE   A 1 154 ? -2.35000  -5.07100  22.83100  1.000 30.67673  ?  306 ILE   A CG2  1 
ATOM   1045 C  CD1  . ILE   A 1 154 ? -1.24200  -3.98600  25.51800  1.000 25.13734  ?  306 ILE   A CD1  1 
ATOM   1046 N  N    . GLU   A 1 155 ? -4.51000  -2.63500  21.06800  1.000 23.17363  ?  307 GLU   A N    1 
ATOM   1047 C  CA   . GLU   A 1 155 ? -5.54300  -3.03500  20.09200  1.000 24.12733  ?  307 GLU   A CA   1 
ATOM   1048 C  C    . GLU   A 1 155 ? -5.15000  -2.52000  18.70800  1.000 26.60127  ?  307 GLU   A C    1 
ATOM   1049 O  O    . GLU   A 1 155 ? -5.00800  -3.32900  17.82900  1.000 23.62157  ?  307 GLU   A O    1 
ATOM   1050 C  CB   . GLU   A 1 155 ? -6.91700  -2.54200  20.52400  1.000 36.06185  ?  307 GLU   A CB   1 
ATOM   1051 C  CG   . GLU   A 1 155 ? -8.01600  -3.37900  19.94300  1.000 47.91803  ?  307 GLU   A CG   1 
ATOM   1052 C  CD   . GLU   A 1 155 ? -9.37800  -3.22700  20.59300  1.000 69.99575  ?  307 GLU   A CD   1 
ATOM   1053 O  OE1  . GLU   A 1 155 ? -9.45300  -2.94900  21.81400  1.000 56.30158  ?  307 GLU   A OE1  1 
ATOM   1054 O  OE2  . GLU   A 1 155 ? -10.35400 -3.36300  19.86400  1.000 71.60035  ?  307 GLU   A OE2  1 
ATOM   1055 N  N    . PRO   A 1 156 ? -4.97000  -1.20600  18.48100  1.000 20.73597  ?  308 PRO   A N    1 
ATOM   1056 C  CA   . PRO   A 1 156 ? -4.54000  -0.76000  17.14200  1.000 20.35297  ?  308 PRO   A CA   1 
ATOM   1057 C  C    . PRO   A 1 156 ? -3.19500  -1.32900  16.72000  1.000 21.44230  ?  308 PRO   A C    1 
ATOM   1058 O  O    . PRO   A 1 156 ? -2.93300  -1.43300  15.51500  1.000 23.64037  ?  308 PRO   A O    1 
ATOM   1059 C  CB   . PRO   A 1 156 ? -4.48800  0.77000   17.26300  1.000 29.42631  ?  308 PRO   A CB   1 
ATOM   1060 C  CG   . PRO   A 1 156 ? -4.50800  1.06500   18.71100  1.000 30.29654  ?  308 PRO   A CG   1 
ATOM   1061 C  CD   . PRO   A 1 156 ? -5.19500  -0.06900  19.39100  1.000 25.24923  ?  308 PRO   A CD   1 
ATOM   1062 N  N    . LEU   A 1 157 ? -2.33400  -1.70000  17.67100  1.000 23.80201  ?  309 LEU   A N    1 
ATOM   1063 C  CA   . LEU   A 1 157 ? -1.06000  -2.32100  17.31700  1.000 21.28035  ?  309 LEU   A CA   1 
ATOM   1064 C  C    . LEU   A 1 157 ? -1.27400  -3.68900  16.68000  1.000 24.79748  ?  309 LEU   A C    1 
ATOM   1065 O  O    . LEU   A 1 157 ? -0.63800  -4.02600  15.67400  1.000 20.00838  ?  309 LEU   A O    1 
ATOM   1066 C  CB   . LEU   A 1 157 ? -0.17000  -2.44500  18.55400  1.000 17.74911  ?  309 LEU   A CB   1 
ATOM   1067 C  CG   . LEU   A 1 157 ? 1.16900   -3.15100  18.32700  1.000 27.38817  ?  309 LEU   A CG   1 
ATOM   1068 C  CD1  . LEU   A 1 157 ? 1.96700   -2.46100  17.21400  1.000 18.55151  ?  309 LEU   A CD1  1 
ATOM   1069 C  CD2  . LEU   A 1 157 ? 1.97600   -3.22300  19.61700  1.000 30.66527  ?  309 LEU   A CD2  1 
ATOM   1070 N  N    . ILE   A 1 158 ? -2.15600  -4.49900  17.26400  1.000 22.08849  ?  310 ILE   A N    1 
ATOM   1071 C  CA   . ILE   A 1 158 ? -2.43900  -5.81400  16.70100  1.000 25.74983  ?  310 ILE   A CA   1 
ATOM   1072 C  C    . ILE   A 1 158 ? -3.13200  -5.67600  15.35200  1.000 21.09525  ?  310 ILE   A C    1 
ATOM   1073 O  O    . ILE   A 1 158 ? -2.81600  -6.40300  14.40100  1.000 24.86814  ?  310 ILE   A O    1 
ATOM   1074 C  CB   . ILE   A 1 158 ? -3.27300  -6.64700  17.69300  1.000 25.88812  ?  310 ILE   A CB   1 
ATOM   1075 C  CG1  . ILE   A 1 158 ? -2.39500  -7.12000  18.85200  1.000 27.26519  ?  310 ILE   A CG1  1 
ATOM   1076 C  CG2  . ILE   A 1 158 ? -3.91500  -7.84000  16.99600  1.000 34.43360  ?  310 ILE   A CG2  1 
ATOM   1077 C  CD1  . ILE   A 1 158 ? -1.35200  -8.14400  18.45000  1.000 31.75948  ?  310 ILE   A CD1  1 
ATOM   1078 N  N    . LYS   A 1 159 ? -4.04000  -4.71100  15.25100  1.000 23.24896  ?  311 LYS   A N    1 
ATOM   1079 C  CA   . LYS   A 1 159 ? -4.75200  -4.45100  13.97300  1.000 25.99696  ?  311 LYS   A CA   1 
ATOM   1080 C  C    . LYS   A 1 159 ? -3.72500  -4.08100  12.89600  1.000 28.28511  ?  311 LYS   A C    1 
ATOM   1081 O  O    . LYS   A 1 159 ? -3.85100  -4.54000  11.78700  1.000 25.50108  ?  311 LYS   A O    1 
ATOM   1082 C  CB   . LYS   A 1 159 ? -5.82400  -3.37400  14.13200  1.000 20.75641  ?  311 LYS   A CB   1 
ATOM   1083 C  CG   . LYS   A 1 159 ? -7.08600  -3.85700  14.82900  1.000 29.86910  ?  311 LYS   A CG   1 
ATOM   1084 C  CD   . LYS   A 1 159 ? -8.11600  -2.78700  15.16600  1.000 49.88417  ?  311 LYS   A CD   1 
ATOM   1085 C  CE   . LYS   A 1 159 ? -9.04800  -3.18400  16.30300  1.000 59.72290  ?  311 LYS   A CE   1 
ATOM   1086 N  NZ   . LYS   A 1 159 ? -9.85900  -2.04900  16.81700  1.000 69.91867  ?  311 LYS   A NZ   1 
ATOM   1087 N  N    . PHE   A 1 160 ? -2.74900  -3.26500  13.25900  1.000 20.53025  ?  312 PHE   A N    1 
ATOM   1088 C  CA   . PHE   A 1 160 ? -1.69600  -2.90500  12.31800  1.000 18.42982  ?  312 PHE   A CA   1 
ATOM   1089 C  C    . PHE   A 1 160 ? -0.89100  -4.13100  11.90200  1.000 16.20495  ?  312 PHE   A C    1 
ATOM   1090 O  O    . PHE   A 1 160 ? -0.62700  -4.33800  10.71200  1.000 20.96653  ?  312 PHE   A O    1 
ATOM   1091 C  CB   . PHE   A 1 160 ? -0.78300  -1.84300  12.93500  1.000 19.27408  ?  312 PHE   A CB   1 
ATOM   1092 C  CG   . PHE   A 1 160 ? 0.46700   -1.58700  12.14300  1.000 19.64120  ?  312 PHE   A CG   1 
ATOM   1093 C  CD1  . PHE   A 1 160 ? 0.46800   -0.67200  11.10200  1.000 23.00084  ?  312 PHE   A CD1  1 
ATOM   1094 C  CD2  . PHE   A 1 160 ? 1.64400   -2.25700  12.44200  1.000 19.67487  ?  312 PHE   A CD2  1 
ATOM   1095 C  CE1  . PHE   A 1 160 ? 1.62200   -0.43500  10.37100  1.000 16.56154  ?  312 PHE   A CE1  1 
ATOM   1096 C  CE2  . PHE   A 1 160 ? 2.79400   -2.02800  11.71200  1.000 23.57597  ?  312 PHE   A CE2  1 
ATOM   1097 C  CZ   . PHE   A 1 160 ? 2.78100   -1.11600  10.67700  1.000 22.37253  ?  312 PHE   A CZ   1 
ATOM   1098 N  N    . GLN   A 1 161 ? -0.48300  -4.95400  12.87500  1.000 16.32225  ?  313 GLN   A N    1 
ATOM   1099 C  CA   . GLN   A 1 161 ? 0.32100   -6.13100  12.55800  1.000 15.59173  ?  313 GLN   A CA   1 
ATOM   1100 C  C    . GLN   A 1 161 ? -0.43600  -7.08100  11.63900  1.000 25.22964  ?  313 GLN   A C    1 
ATOM   1101 O  O    . GLN   A 1 161 ? 0.15300   -7.67900  10.72900  1.000 21.83583  ?  313 GLN   A O    1 
ATOM   1102 C  CB   . GLN   A 1 161 ? 0.74100   -6.85500  13.83900  1.000 21.85595  ?  313 GLN   A CB   1 
ATOM   1103 C  CG   . GLN   A 1 161 ? 1.63100   -6.04700  14.78100  1.000 24.20902  ?  313 GLN   A CG   1 
ATOM   1104 C  CD   . GLN   A 1 161 ? 3.04800   -5.86600  14.25900  1.000 34.08716  ?  313 GLN   A CD   1 
ATOM   1105 O  OE1  . GLN   A 1 161 ? 3.57600   -6.71900  13.54300  1.000 28.90350  ?  313 GLN   A OE1  1 
ATOM   1106 N  NE2  . GLN   A 1 161 ? 3.67000   -4.74700  14.61800  1.000 28.38866  ?  313 GLN   A NE2  1 
ATOM   1107 N  N    . VAL   A 1 162 ? -1.74500  -7.22800  11.85800  1.000 20.73734  ?  314 VAL   A N    1 
ATOM   1108 C  CA   . VAL   A 1 162 ? -2.54500  -8.12200  11.02600  1.000 20.63708  ?  314 VAL   A CA   1 
ATOM   1109 C  C    . VAL   A 1 162 ? -2.66500  -7.56900  9.61200   1.000 20.74757  ?  314 VAL   A C    1 
ATOM   1110 O  O    . VAL   A 1 162 ? -2.47900  -8.29400  8.62600   1.000 28.71531  ?  314 VAL   A O    1 
ATOM   1111 C  CB   . VAL   A 1 162 ? -3.92700  -8.35500  11.66600  1.000 27.02717  ?  314 VAL   A CB   1 
ATOM   1112 C  CG1  . VAL   A 1 162 ? -4.86200  -9.04200  10.68300  1.000 29.58329  ?  314 VAL   A CG1  1 
ATOM   1113 C  CG2  . VAL   A 1 162 ? -3.78600  -9.18000  12.93900  1.000 23.26131  ?  314 VAL   A CG2  1 
ATOM   1114 N  N    . GLY   A 1 163 ? -2.97200  -6.27400  9.49100   1.000 21.14032  ?  315 GLY   A N    1 
ATOM   1115 C  CA   . GLY   A 1 163 ? -3.07700  -5.66500  8.17500   1.000 21.80571  ?  315 GLY   A CA   1 
ATOM   1116 C  C    . GLY   A 1 163 ? -1.77000  -5.68700  7.40700   1.000 24.33460  ?  315 GLY   A C    1 
ATOM   1117 O  O    . GLY   A 1 163 ? -1.76700  -5.84500  6.18300   1.000 21.38904  ?  315 GLY   A O    1 
ATOM   1118 N  N    . LEU   A 1 164 ? -0.64500  -5.53800  8.11000   1.000 21.91176  ?  316 LEU   A N    1 
ATOM   1119 C  CA   . LEU   A 1 164 ? 0.65400   -5.57700  7.44400   1.000 24.92002  ?  316 LEU   A CA   1 
ATOM   1120 C  C    . LEU   A 1 164 ? 1.00500   -6.99100  6.99900   1.000 26.13982  ?  316 LEU   A C    1 
ATOM   1121 O  O    . LEU   A 1 164 ? 1.48900   -7.19100  5.87800   1.000 19.40928  ?  316 LEU   A O    1 
ATOM   1122 C  CB   . LEU   A 1 164 ? 1.73600   -5.02400  8.37200   1.000 23.66185  ?  316 LEU   A CB   1 
ATOM   1123 C  CG   . LEU   A 1 164 ? 3.11400   -4.78600  7.76300   1.000 31.07099  ?  316 LEU   A CG   1 
ATOM   1124 C  CD1  . LEU   A 1 164 ? 3.02200   -3.81600  6.59300   1.000 23.67041  ?  316 LEU   A CD1  1 
ATOM   1125 C  CD2  . LEU   A 1 164 ? 4.06200   -4.26800  8.83000   1.000 25.58828  ?  316 LEU   A CD2  1 
ATOM   1126 N  N    . LYS   A 1 165 ? 0.76900   -7.98200  7.86500   1.000 21.88317  ?  317 LYS   A N    1 
ATOM   1127 C  CA   . LYS   A 1 165 ? 1.04600   -9.36900  7.50600   1.000 26.87673  ?  317 LYS   A CA   1 
ATOM   1128 C  C    . LYS   A 1 165 ? 0.27000   -9.79000  6.26400   1.000 27.80158  ?  317 LYS   A C    1 
ATOM   1129 O  O    . LYS   A 1 165 ? 0.82400   -10.43500 5.36500   1.000 23.93752  ?  317 LYS   A O    1 
ATOM   1130 C  CB   . LYS   A 1 165 ? 0.70800   -10.29200 8.67700   1.000 29.47248  ?  317 LYS   A CB   1 
ATOM   1131 C  CG   . LYS   A 1 165 ? 1.48900   -11.59700 8.69000   1.000 26.74727  ?  317 LYS   A CG   1 
ATOM   1132 C  CD   . LYS   A 1 165 ? 2.94800   -11.37300 9.05400   1.000 25.80854  ?  317 LYS   A CD   1 
ATOM   1133 C  CE   . LYS   A 1 165 ? 3.76000   -12.64500 8.88800   1.000 34.85001  ?  317 LYS   A CE   1 
ATOM   1134 N  NZ   . LYS   A 1 165 ? 5.10000   -12.52000 9.52700   1.000 31.13088  ?  317 LYS   A NZ   1 
ATOM   1135 N  N    . LYS   A 1 166 ? -1.01000  -9.42900  6.18800   1.000 20.76323  ?  318 LYS   A N    1 
ATOM   1136 C  CA   . LYS   A 1 166 ? -1.81000  -9.84900  5.04500   1.000 26.75875  ?  318 LYS   A CA   1 
ATOM   1137 C  C    . LYS   A 1 166 ? -1.38000  -9.21000  3.73300   1.000 36.36783  ?  318 LYS   A C    1 
ATOM   1138 O  O    . LYS   A 1 166 ? -1.84200  -9.65900  2.68100   1.000 29.68496  ?  318 LYS   A O    1 
ATOM   1139 C  CB   . LYS   A 1 166 ? -3.29100  -9.54500  5.29900   1.000 35.69954  ?  318 LYS   A CB   1 
ATOM   1140 C  CG   . LYS   A 1 166 ? -3.72800  -8.12200  4.99100   1.000 34.77720  ?  318 LYS   A CG   1 
ATOM   1141 C  CD   . LYS   A 1 166 ? -5.13000  -8.10500  4.40300   1.000 62.00595  ?  318 LYS   A CD   1 
ATOM   1142 C  CE   . LYS   A 1 166 ? -5.39900  -6.82800  3.60500   1.000 57.47819  ?  318 LYS   A CE   1 
ATOM   1143 N  NZ   . LYS   A 1 166 ? -4.85300  -6.96500  2.21700   1.000 47.27720  ?  318 LYS   A NZ   1 
ATOM   1144 N  N    . LEU   A 1 167 ? -0.52400  -8.18300  3.76600   1.000 21.50986  ?  319 LEU   A N    1 
ATOM   1145 C  CA   . LEU   A 1 167 ? 0.01600   -7.62900  2.53200   1.000 20.19395  ?  319 LEU   A CA   1 
ATOM   1146 C  C    . LEU   A 1 167 ? 1.03100   -8.55700  1.87500   1.000 16.77408  ?  319 LEU   A C    1 
ATOM   1147 O  O    . LEU   A 1 167 ? 1.30200   -8.40000  0.68000   1.000 21.42646  ?  319 LEU   A O    1 
ATOM   1148 C  CB   . LEU   A 1 167 ? 0.66200   -6.26700  2.79700   1.000 22.38295  ?  319 LEU   A CB   1 
ATOM   1149 C  CG   . LEU   A 1 167 ? -0.26400  -5.09300  3.12800   1.000 24.09146  ?  319 LEU   A CG   1 
ATOM   1150 C  CD1  . LEU   A 1 167 ? 0.51400   -3.78400  3.15300   1.000 29.63680  ?  319 LEU   A CD1  1 
ATOM   1151 C  CD2  . LEU   A 1 167 ? -1.42900  -5.00900  2.14800   1.000 23.46682  ?  319 LEU   A CD2  1 
ATOM   1152 N  N    A ASN   A 1 168 ? 1.58500   -9.51000  2.62800   0.550 19.73446  ?  320 ASN   A N    1 
ATOM   1153 N  N    B ASN   A 1 168 ? 1.60300   -9.50100  2.62300   0.450 19.76232  ?  320 ASN   A N    1 
ATOM   1154 C  CA   A ASN   A 1 168 ? 2.57400   -10.47200 2.13300   0.550 19.52814  ?  320 ASN   A CA   1 
ATOM   1155 C  CA   B ASN   A 1 168 ? 2.56000   -10.47400 2.09000   0.450 19.61226  ?  320 ASN   A CA   1 
ATOM   1156 C  C    A ASN   A 1 168 ? 3.69500   -9.77300  1.36700   0.550 23.39941  ?  320 ASN   A C    1 
ATOM   1157 C  C    B ASN   A 1 168 ? 3.71100   -9.78100  1.35900   0.450 23.38705  ?  320 ASN   A C    1 
ATOM   1158 O  O    A ASN   A 1 168 ? 3.99100   -10.09100 0.21300   0.550 23.64542  ?  320 ASN   A O    1 
ATOM   1159 O  O    B ASN   A 1 168 ? 4.04300   -10.10900 0.21800   0.450 23.67086  ?  320 ASN   A O    1 
ATOM   1160 C  CB   A ASN   A 1 168 ? 1.91100   -11.55300 1.27400   0.550 25.89571  ?  320 ASN   A CB   1 
ATOM   1161 C  CB   B ASN   A 1 168 ? 1.86200   -11.48100 1.16900   0.450 25.69488  ?  320 ASN   A CB   1 
ATOM   1162 C  CG   A ASN   A 1 168 ? 2.79600   -12.77300 1.09100   0.550 29.86881  ?  320 ASN   A CG   1 
ATOM   1163 C  CG   B ASN   A 1 168 ? 0.69400   -12.17900 1.84100   0.450 28.88761  ?  320 ASN   A CG   1 
ATOM   1164 O  OD1  A ASN   A 1 168 ? 3.68000   -13.04100 1.90700   0.550 29.13682  ?  320 ASN   A OD1  1 
ATOM   1165 O  OD1  B ASN   A 1 168 ? 0.78400   -12.59700 2.99500   0.450 24.70685  ?  320 ASN   A OD1  1 
ATOM   1166 N  ND2  A ASN   A 1 168 ? 2.56300   -13.51900 0.01700   0.550 27.29569  ?  320 ASN   A ND2  1 
ATOM   1167 N  ND2  B ASN   A 1 168 ? -0.41200  -12.31000 1.11600   0.450 22.49115  ?  320 ASN   A ND2  1 
ATOM   1168 N  N    . LEU   A 1 169 ? 4.32400   -8.80800  2.03000   1.000 18.27427  ?  321 LEU   A N    1 
ATOM   1169 C  CA   . LEU   A 1 169 ? 5.37500   -8.01700  1.40400   1.000 21.20876  ?  321 LEU   A CA   1 
ATOM   1170 C  C    . LEU   A 1 169 ? 6.60600   -8.85800  1.08600   1.000 20.32904  ?  321 LEU   A C    1 
ATOM   1171 O  O    . LEU   A 1 169 ? 6.99400   -9.74300  1.85400   1.000 19.74366  ?  321 LEU   A O    1 
ATOM   1172 C  CB   . LEU   A 1 169 ? 5.78100   -6.85900  2.31500   1.000 18.95361  ?  321 LEU   A CB   1 
ATOM   1173 C  CG   . LEU   A 1 169 ? 4.75700   -5.76700  2.63900   1.000 15.89311  ?  321 LEU   A CG   1 
ATOM   1174 C  CD1  . LEU   A 1 169 ? 5.46000   -4.59000  3.30000   1.000 23.49100  ?  321 LEU   A CD1  1 
ATOM   1175 C  CD2  . LEU   A 1 169 ? 4.02500   -5.31300  1.39000   1.000 21.74874  ?  321 LEU   A CD2  1 
ATOM   1176 N  N    . HIS   A 1 170 ? 7.22400   -8.57100  -0.05600  1.000 21.36086  ?  322 HIS   A N    1 
ATOM   1177 C  CA   . HIS   A 1 170 ? 8.56700   -9.06300  -0.31300  1.000 17.44025  ?  322 HIS   A CA   1 
ATOM   1178 C  C    . HIS   A 1 170 ? 9.55900   -8.31600  0.57100   1.000 20.42279  ?  322 HIS   A C    1 
ATOM   1179 O  O    . HIS   A 1 170 ? 9.28900   -7.21000  1.05000   1.000 20.68737  ?  322 HIS   A O    1 
ATOM   1180 C  CB   . HIS   A 1 170 ? 8.93300   -8.88400  -1.78800  1.000 19.51335  ?  322 HIS   A CB   1 
ATOM   1181 C  CG   . HIS   A 1 170 ? 8.06500   -9.66900  -2.72200  1.000 30.56341  ?  322 HIS   A CG   1 
ATOM   1182 N  ND1  . HIS   A 1 170 ? 6.83200   -9.22000  -3.14400  1.000 35.30600  ?  322 HIS   A ND1  1 
ATOM   1183 C  CD2  . HIS   A 1 170 ? 8.24900   -10.87300 -3.31100  1.000 41.53036  ?  322 HIS   A CD2  1 
ATOM   1184 C  CE1  . HIS   A 1 170 ? 6.29600   -10.11300 -3.95600  1.000 41.00810  ?  322 HIS   A CE1  1 
ATOM   1185 N  NE2  . HIS   A 1 170 ? 7.13500   -11.12700 -4.07300  1.000 44.10231  ?  322 HIS   A NE2  1 
ATOM   1186 N  N    . GLU   A 1 171 ? 10.71900  -8.94000  0.80200   1.000 21.07405  ?  323 GLU   A N    1 
ATOM   1187 C  CA   . GLU   A 1 171 ? 11.74000  -8.28900  1.61900   1.000 20.35890  ?  323 GLU   A CA   1 
ATOM   1188 C  C    . GLU   A 1 171 ? 12.16600  -6.95600  1.02000   1.000 19.52325  ?  323 GLU   A C    1 
ATOM   1189 O  O    . GLU   A 1 171 ? 12.48800  -6.02000  1.75900   1.000 19.83289  ?  323 GLU   A O    1 
ATOM   1190 C  CB   . GLU   A 1 171 ? 12.95500  -9.20000  1.79300   1.000 23.88916  ?  323 GLU   A CB   1 
ATOM   1191 C  CG   . GLU   A 1 171 ? 13.96300  -8.66200  2.80200   1.000 30.00973  ?  323 GLU   A CG   1 
ATOM   1192 C  CD   . GLU   A 1 171 ? 15.10900  -9.62000  3.06900   1.000 31.08174  ?  323 GLU   A CD   1 
ATOM   1193 O  OE1  . GLU   A 1 171 ? 15.55800  -10.29300 2.11900   1.000 31.64664  ?  323 GLU   A OE1  1 
ATOM   1194 O  OE2  . GLU   A 1 171 ? 15.56800  -9.69300  4.22800   1.000 38.22770  ?  323 GLU   A OE2  1 
ATOM   1195 N  N    . GLU   A 1 172 ? 12.16200  -6.85000  -0.31200  1.000 18.84495  ?  324 GLU   A N    1 
ATOM   1196 C  CA   . GLU   A 1 172 ? 12.50200  -5.59000  -0.96700  1.000 16.73354  ?  324 GLU   A CA   1 
ATOM   1197 C  C    . GLU   A 1 172 ? 11.52800  -4.48600  -0.57500  1.000 20.02425  ?  324 GLU   A C    1 
ATOM   1198 O  O    . GLU   A 1 172 ? 11.94100  -3.35900  -0.28100  1.000 18.14096  ?  324 GLU   A O    1 
ATOM   1199 C  CB   . GLU   A 1 172 ? 12.51100  -5.77600  -2.48800  1.000 14.91288  ?  324 GLU   A CB   1 
ATOM   1200 C  CG   . GLU   A 1 172 ? 13.68400  -6.58300  -3.02100  1.000 16.05369  ?  324 GLU   A CG   1 
ATOM   1201 C  CD   . GLU   A 1 172 ? 13.44900  -8.08400  -2.97700  1.000 27.76700  ?  324 GLU   A CD   1 
ATOM   1202 O  OE1  . GLU   A 1 172 ? 12.44800  -8.52400  -2.37500  1.000 22.60472  ?  324 GLU   A OE1  1 
ATOM   1203 O  OE2  . GLU   A 1 172 ? 14.27300  -8.82600  -3.54700  1.000 29.26459  ?  324 GLU   A OE2  1 
ATOM   1204 N  N    . GLU   A 1 173 ? 10.22800  -4.78900  -0.56900  1.000 17.08944  ?  325 GLU   A N    1 
ATOM   1205 C  CA   . GLU   A 1 173 ? 9.23800   -3.79500  -0.16800  1.000 18.15971  ?  325 GLU   A CA   1 
ATOM   1206 C  C    . GLU   A 1 173 ? 9.34700   -3.48000  1.31800   1.000 17.14831  ?  325 GLU   A C    1 
ATOM   1207 O  O    . GLU   A 1 173 ? 9.11400   -2.33800  1.73100   1.000 17.04286  ?  325 GLU   A O    1 
ATOM   1208 C  CB   . GLU   A 1 173 ? 7.83300   -4.29400  -0.52300  1.000 17.94676  ?  325 GLU   A CB   1 
ATOM   1209 C  CG   . GLU   A 1 173 ? 7.61500   -4.44800  -2.02500  1.000 15.79156  ?  325 GLU   A CG   1 
ATOM   1210 C  CD   . GLU   A 1 173 ? 6.55800   -5.47900  -2.38300  1.000 24.35526  ?  325 GLU   A CD   1 
ATOM   1211 O  OE1  . GLU   A 1 173 ? 5.99400   -5.37800  -3.49100  1.000 22.08964  ?  325 GLU   A OE1  1 
ATOM   1212 O  OE2  . GLU   A 1 173 ? 6.29900   -6.39200  -1.57200  1.000 22.17597  ?  325 GLU   A OE2  1 
ATOM   1213 N  N    . HIS   A 1 174 ? 9.72400   -4.47800  2.12100   1.000 12.57707  ?  326 HIS   A N    1 
ATOM   1214 C  CA   . HIS   A 1 174 ? 9.87600   -4.30500  3.56200   1.000 16.85377  ?  326 HIS   A CA   1 
ATOM   1215 C  C    . HIS   A 1 174 ? 10.99000  -3.31000  3.89200   1.000 20.25628  ?  326 HIS   A C    1 
ATOM   1216 O  O    . HIS   A 1 174 ? 10.79100  -2.37900  4.68300   1.000 15.80863  ?  326 HIS   A O    1 
ATOM   1217 C  CB   . HIS   A 1 174 ? 10.14100  -5.67800  4.19100   1.000 17.26782  ?  326 HIS   A CB   1 
ATOM   1218 C  CG   . HIS   A 1 174 ? 10.30800  -5.66500  5.67900   1.000 20.66001  ?  326 HIS   A CG   1 
ATOM   1219 N  ND1  . HIS   A 1 174 ? 9.36100   -5.14500  6.53600   1.000 26.85193  ?  326 HIS   A ND1  1 
ATOM   1220 C  CD2  . HIS   A 1 174 ? 11.29600  -6.15700  6.46500   1.000 24.38242  ?  326 HIS   A CD2  1 
ATOM   1221 C  CE1  . HIS   A 1 174 ? 9.77200   -5.29200  7.78300   1.000 27.42007  ?  326 HIS   A CE1  1 
ATOM   1222 N  NE2  . HIS   A 1 174 ? 10.94100  -5.90600  7.76800   1.000 22.03719  ?  326 HIS   A NE2  1 
ATOM   1223 N  N    . VAL   A 1 175 ? 12.17000  -3.48400  3.29100   1.000 18.04422  ?  327 VAL   A N    1 
ATOM   1224 C  CA   . VAL   A 1 175 ? 13.29000  -2.59900  3.61100   1.000 14.98294  ?  327 VAL   A CA   1 
ATOM   1225 C  C    . VAL   A 1 175 ? 13.04900  -1.19800  3.05800   1.000 13.02726  ?  327 VAL   A C    1 
ATOM   1226 O  O    . VAL   A 1 175 ? 13.44900  -0.20200  3.67100   1.000 12.37078  ?  327 VAL   A O    1 
ATOM   1227 C  CB   . VAL   A 1 175 ? 14.62000  -3.19300  3.10700   1.000 16.82055  ?  327 VAL   A CB   1 
ATOM   1228 C  CG1  . VAL   A 1 175 ? 14.90800  -4.51100  3.81300   1.000 16.61688  ?  327 VAL   A CG1  1 
ATOM   1229 C  CG2  . VAL   A 1 175 ? 14.61800  -3.37600  1.59000   1.000 15.36792  ?  327 VAL   A CG2  1 
ATOM   1230 N  N    . LEU   A 1 176 ? 12.40100  -1.09200  1.89600   1.000 12.59528  ?  328 LEU   A N    1 
ATOM   1231 C  CA   . LEU   A 1 176 ? 12.08100  0.22900   1.36600   1.000 13.34758  ?  328 LEU   A CA   1 
ATOM   1232 C  C    . LEU   A 1 176 ? 11.09900  0.95600   2.27600   1.000 17.02704  ?  328 LEU   A C    1 
ATOM   1233 O  O    . LEU   A 1 176 ? 11.23900  2.16000   2.51600   1.000 12.89767  ?  328 LEU   A O    1 
ATOM   1234 C  CB   . LEU   A 1 176 ? 11.51700  0.11100   -0.05300  1.000 12.98990  ?  328 LEU   A CB   1 
ATOM   1235 C  CG   . LEU   A 1 176 ? 12.53000  -0.18400  -1.16300  1.000 15.60455  ?  328 LEU   A CG   1 
ATOM   1236 C  CD1  . LEU   A 1 176 ? 11.82000  -0.73100  -2.39500  1.000 13.53246  ?  328 LEU   A CD1  1 
ATOM   1237 C  CD2  . LEU   A 1 176 ? 13.33300  1.06200   -1.51000  1.000 13.26238  ?  328 LEU   A CD2  1 
ATOM   1238 N  N    . LEU   A 1 177 ? 10.11000  0.23400   2.80700   1.000 14.66541  ?  329 LEU   A N    1 
ATOM   1239 C  CA   . LEU   A 1 177 ? 9.13600   0.85100   3.70400   1.000 15.05071  ?  329 LEU   A CA   1 
ATOM   1240 C  C    . LEU   A 1 177 ? 9.80200   1.36600   4.97400   1.000 11.80877  ?  329 LEU   A C    1 
ATOM   1241 O  O    . LEU   A 1 177 ? 9.50900   2.47600   5.43100   1.000 15.05936  ?  329 LEU   A O    1 
ATOM   1242 C  CB   . LEU   A 1 177 ? 8.03800   -0.15400  4.05500   1.000 14.64047  ?  329 LEU   A CB   1 
ATOM   1243 C  CG   . LEU   A 1 177 ? 6.66600   0.43000   4.39400   1.000 32.91689  ?  329 LEU   A CG   1 
ATOM   1244 C  CD1  . LEU   A 1 177 ? 6.16100   1.30500   3.25200   1.000 24.42722  ?  329 LEU   A CD1  1 
ATOM   1245 C  CD2  . LEU   A 1 177 ? 5.67700   -0.68400  4.71300   1.000 27.43756  ?  329 LEU   A CD2  1 
ATOM   1246 N  N    . MET   A 1 178 ? 10.69800  0.57000   5.56200   1.000 11.41079  ?  330 MET   A N    1 
ATOM   1247 C  CA   . MET   A 1 178 ? 11.41900  1.02300   6.74700   1.000 11.42035  ?  330 MET   A CA   1 
ATOM   1248 C  C    . MET   A 1 178 ? 12.28600  2.23900   6.44000   1.000 11.56024  ?  330 MET   A C    1 
ATOM   1249 O  O    . MET   A 1 178 ? 12.36100  3.17500   7.24300   1.000 13.64532  ?  330 MET   A O    1 
ATOM   1250 C  CB   . MET   A 1 178 ? 12.27100  -0.11600  7.30600   1.000 15.12482  ?  330 MET   A CB   1 
ATOM   1251 C  CG   . MET   A 1 178 ? 11.45700  -1.25600  7.90800   1.000 16.75435  ?  330 MET   A CG   1 
ATOM   1252 S  SD   . MET   A 1 178 ? 12.49700  -2.44800  8.77700   1.000 18.48075  ?  330 MET   A SD   1 
ATOM   1253 C  CE   . MET   A 1 178 ? 13.26900  -3.27700  7.39000   1.000 17.78701  ?  330 MET   A CE   1 
ATOM   1254 N  N    . ALA   A 1 179 ? 12.95500  2.24300   5.28300   1.000 11.79953  ?  331 ALA   A N    1 
ATOM   1255 C  CA   . ALA   A 1 179 ? 13.78400  3.38900   4.92200   1.000 13.35889  ?  331 ALA   A CA   1 
ATOM   1256 C  C    . ALA   A 1 179 ? 12.93300  4.63200   4.68600   1.000 14.51655  ?  331 ALA   A C    1 
ATOM   1257 O  O    . ALA   A 1 179 ? 13.28500  5.72700   5.13900   1.000 13.12022  ?  331 ALA   A O    1 
ATOM   1258 C  CB   . ALA   A 1 179 ? 14.62100  3.06000   3.68600   1.000 10.35103  ?  331 ALA   A CB   1 
ATOM   1259 N  N    . ILE   A 1 180 ? 11.80800  4.47700   3.98200   1.000 8.82962   ?  332 ILE   A N    1 
ATOM   1260 C  CA   . ILE   A 1 180 ? 10.89600  5.59700   3.74700   1.000 10.01069  ?  332 ILE   A CA   1 
ATOM   1261 C  C    . ILE   A 1 180 ? 10.40600  6.16500   5.07300   1.000 17.83215  ?  332 ILE   A C    1 
ATOM   1262 O  O    . ILE   A 1 180 ? 10.28900  7.38400   5.24800   1.000 13.89281  ?  332 ILE   A O    1 
ATOM   1263 C  CB   . ILE   A 1 180 ? 9.72300   5.13600   2.85700   1.000 15.01621  ?  332 ILE   A CB   1 
ATOM   1264 C  CG1  . ILE   A 1 180 ? 10.20000  4.91300   1.42100   1.000 17.44676  ?  332 ILE   A CG1  1 
ATOM   1265 C  CG2  . ILE   A 1 180 ? 8.56400   6.12900   2.89700   1.000 15.47672  ?  332 ILE   A CG2  1 
ATOM   1266 C  CD1  . ILE   A 1 180 ? 9.24400   4.05900   0.57900   1.000 14.42148  ?  332 ILE   A CD1  1 
ATOM   1267 N  N    . CYS   A 1 181 ? 10.13400  5.28400   6.03100   1.000 15.34156  ?  333 CYS   A N    1 
ATOM   1268 C  CA   . CYS   A 1 181 ? 9.67900   5.70700   7.34700   1.000 17.58116  ?  333 CYS   A CA   1 
ATOM   1269 C  C    . CYS   A 1 181 ? 10.72200  6.57800   8.04300   1.000 17.82699  ?  333 CYS   A C    1 
ATOM   1270 O  O    . CYS   A 1 181 ? 10.38500  7.59200   8.66600   1.000 16.55753  ?  333 CYS   A O    1 
ATOM   1271 C  CB   . CYS   A 1 181 ? 9.35200   4.45900   8.17000   1.000 24.29634  ?  333 CYS   A CB   1 
ATOM   1272 S  SG   . CYS   A 1 181 ? 8.75200   4.73400   9.81900   1.000 27.20709  ?  333 CYS   A SG   1 
ATOM   1273 N  N    . ILE   A 1 182 ? 11.99800  6.21700   7.91300   1.000 14.55850  ?  334 ILE   A N    1 
ATOM   1274 C  CA   . ILE   A 1 182 ? 13.06200  6.91900   8.62700   1.000 13.48302  ?  334 ILE   A CA   1 
ATOM   1275 C  C    . ILE   A 1 182 ? 13.28500  8.31300   8.04500   1.000 16.55765  ?  334 ILE   A C    1 
ATOM   1276 O  O    . ILE   A 1 182 ? 13.38400  9.30400   8.78200   1.000 15.27857  ?  334 ILE   A O    1 
ATOM   1277 C  CB   . ILE   A 1 182 ? 14.35000  6.07500   8.60200   1.000 13.98273  ?  334 ILE   A CB   1 
ATOM   1278 C  CG1  . ILE   A 1 182 ? 14.18500  4.83900   9.50100   1.000 11.72709  ?  334 ILE   A CG1  1 
ATOM   1279 C  CG2  . ILE   A 1 182 ? 15.56000  6.89800   9.00500   1.000 13.81848  ?  334 ILE   A CG2  1 
ATOM   1280 C  CD1  . ILE   A 1 182 ? 15.26300  3.77700   9.31100   1.000 12.43869  ?  334 ILE   A CD1  1 
ATOM   1281 N  N    A VAL   A 1 183 ? 13.37800  8.42000   6.71800   0.620 13.75387  ?  335 VAL   A N    1 
ATOM   1282 N  N    B VAL   A 1 183 ? 13.34600  8.40700   6.72300   0.380 13.88820  ?  335 VAL   A N    1 
ATOM   1283 C  CA   A VAL   A 1 183 ? 13.64000  9.72000   6.10400   0.620 14.77891  ?  335 VAL   A CA   1 
ATOM   1284 C  CA   B VAL   A 1 183 ? 13.61800  9.66900   6.05500   0.380 14.86977  ?  335 VAL   A CA   1 
ATOM   1285 C  C    A VAL   A 1 183 ? 12.32300  10.41600  5.77600   0.620 17.34040  ?  335 VAL   A C    1 
ATOM   1286 C  C    B VAL   A 1 183 ? 12.28800  10.35400  5.75400   0.380 17.27080  ?  335 VAL   A C    1 
ATOM   1287 O  O    A VAL   A 1 183 ? 12.00600  10.66600  4.60700   0.620 14.27207  ?  335 VAL   A O    1 
ATOM   1288 O  O    B VAL   A 1 183 ? 11.90100  10.50600  4.59000   0.380 14.35698  ?  335 VAL   A O    1 
ATOM   1289 C  CB   A VAL   A 1 183 ? 14.52800  9.60900   4.84800   0.620 15.59141  ?  335 VAL   A CB   1 
ATOM   1290 C  CB   B VAL   A 1 183 ? 14.46400  9.42500   4.78800   0.380 15.85143  ?  335 VAL   A CB   1 
ATOM   1291 C  CG1  A VAL   A 1 183 ? 15.96700  9.32400   5.24300   0.620 16.75393  ?  335 VAL   A CG1  1 
ATOM   1292 C  CG1  B VAL   A 1 183 ? 14.88000  10.71700  4.13800   0.380 12.39304  ?  335 VAL   A CG1  1 
ATOM   1293 C  CG2  A VAL   A 1 183 ? 14.01000  8.54300   3.89700   0.620 10.00364  ?  335 VAL   A CG2  1 
ATOM   1294 C  CG2  B VAL   A 1 183 ? 15.70100  8.61200   5.14600   0.380 15.16944  ?  335 VAL   A CG2  1 
ATOM   1295 N  N    . SER   A 1 184 ? 11.56100  10.74600  6.81000   1.000 14.56622  ?  336 SER   A N    1 
ATOM   1296 C  CA   . SER   A 1 184 ? 10.30700  11.47200  6.65200   1.000 15.77365  ?  336 SER   A CA   1 
ATOM   1297 C  C    . SER   A 1 184 ? 10.56600  12.96100  6.82400   1.000 12.43773  ?  336 SER   A C    1 
ATOM   1298 O  O    . SER   A 1 184 ? 11.00800  13.37900  7.90500   1.000 15.52272  ?  336 SER   A O    1 
ATOM   1299 C  CB   . SER   A 1 184 ? 9.27500   10.99600  7.66500   1.000 18.42905  ?  336 SER   A CB   1 
ATOM   1300 O  OG   . SER   A 1 184 ? 8.86800   9.66400   7.39700   1.000 22.62277  ?  336 SER   A OG   1 
ATOM   1301 N  N    . PRO   A 1 185 ? 10.31200  13.79400  5.81100   1.000 14.62892  ?  337 PRO   A N    1 
ATOM   1302 C  CA   . PRO   A 1 185 ? 10.64700  15.21800  5.93100   1.000 13.89339  ?  337 PRO   A CA   1 
ATOM   1303 C  C    . PRO   A 1 185 ? 9.71300   16.00600  6.83400   1.000 16.29954  ?  337 PRO   A C    1 
ATOM   1304 O  O    . PRO   A 1 185 ? 10.04500  17.15000  7.18300   1.000 21.89503  ?  337 PRO   A O    1 
ATOM   1305 C  CB   . PRO   A 1 185 ? 10.56600  15.71800  4.48200   1.000 15.43040  ?  337 PRO   A CB   1 
ATOM   1306 C  CG   . PRO   A 1 185 ? 9.59100   14.78500  3.82500   1.000 20.53844  ?  337 PRO   A CG   1 
ATOM   1307 C  CD   . PRO   A 1 185 ? 9.75800   13.45100  4.49100   1.000 13.70259  ?  337 PRO   A CD   1 
ATOM   1308 N  N    . ASP   A 1 186 ? 8.58000   15.43800  7.24300   1.000 15.22844  ?  338 ASP   A N    1 
ATOM   1309 C  CA   . ASP   A 1 186 ? 7.61800   16.14500  8.07800   1.000 17.13717  ?  338 ASP   A CA   1 
ATOM   1310 C  C    . ASP   A 1 186 ? 7.78600   15.83700  9.56400   1.000 22.69604  ?  338 ASP   A C    1 
ATOM   1311 O  O    . ASP   A 1 186 ? 6.86000   16.07300  10.34600  1.000 31.22283  ?  338 ASP   A O    1 
ATOM   1312 C  CB   . ASP   A 1 186 ? 6.18900   15.82900  7.63000   1.000 20.48890  ?  338 ASP   A CB   1 
ATOM   1313 C  CG   . ASP   A 1 186 ? 5.86500   14.34900  7.70100   1.000 32.29195  ?  338 ASP   A CG   1 
ATOM   1314 O  OD1  . ASP   A 1 186 ? 4.67600   14.01100  7.88600   1.000 36.13044  ?  338 ASP   A OD1  1 
ATOM   1315 O  OD2  . ASP   A 1 186 ? 6.79500   13.52500  7.56400   1.000 32.18866  ?  338 ASP   A OD2  1 
ATOM   1316 N  N    . ARG   A 1 187 ? 8.93800   15.31700  9.97100   1.000 18.66629  ?  339 ARG   A N    1 
ATOM   1317 C  CA   . ARG   A 1 187 ? 9.18300   15.11300  11.39300  1.000 17.76892  ?  339 ARG   A CA   1 
ATOM   1318 C  C    . ARG   A 1 187 ? 9.43100   16.45800  12.06800  1.000 21.87135  ?  339 ARG   A C    1 
ATOM   1319 O  O    . ARG   A 1 187 ? 10.06600  17.34000  11.47900  1.000 25.45719  ?  339 ARG   A O    1 
ATOM   1320 C  CB   . ARG   A 1 187 ? 10.38700  14.19600  11.62100  1.000 18.69460  ?  339 ARG   A CB   1 
ATOM   1321 C  CG   . ARG   A 1 187 ? 10.27800  12.82600  10.98100  1.000 23.49656  ?  339 ARG   A CG   1 
ATOM   1322 C  CD   . ARG   A 1 187 ? 9.23300   11.95100  11.65900  1.000 21.67482  ?  339 ARG   A CD   1 
ATOM   1323 N  NE   . ARG   A 1 187 ? 9.33100   10.56900  11.19500  1.000 24.67220  ?  339 ARG   A NE   1 
ATOM   1324 C  CZ   . ARG   A 1 187 ? 8.48400   9.60100   11.52900  1.000 18.92592  ?  339 ARG   A CZ   1 
ATOM   1325 N  NH1  . ARG   A 1 187 ? 7.46200   9.85900   12.33700  1.000 16.95926  ?  339 ARG   A NH1  1 
ATOM   1326 N  NH2  . ARG   A 1 187 ? 8.65400   8.37600   11.04700  1.000 18.81533  ?  339 ARG   A NH2  1 
ATOM   1327 N  N    . PRO   A 1 188 ? 8.94900   16.64600  13.29500  1.000 26.91465  ?  340 PRO   A N    1 
ATOM   1328 C  CA   . PRO   A 1 188 ? 9.21500   17.90500  14.00000  1.000 19.35685  ?  340 PRO   A CA   1 
ATOM   1329 C  C    . PRO   A 1 188 ? 10.69600  18.05300  14.30200  1.000 28.17052  ?  340 PRO   A C    1 
ATOM   1330 O  O    . PRO   A 1 188 ? 11.35900  17.10300  14.72000  1.000 22.94641  ?  340 PRO   A O    1 
ATOM   1331 C  CB   . PRO   A 1 188 ? 8.39000   17.77800  15.28900  1.000 22.06523  ?  340 PRO   A CB   1 
ATOM   1332 C  CG   . PRO   A 1 188 ? 7.45200   16.63000  15.05500  1.000 28.28474  ?  340 PRO   A CG   1 
ATOM   1333 C  CD   . PRO   A 1 188 ? 8.15400   15.71300  14.10700  1.000 23.24126  ?  340 PRO   A CD   1 
ATOM   1334 N  N    . GLY   A 1 189 ? 11.21600  19.25700  14.06900  1.000 16.79165  ?  341 GLY   A N    1 
ATOM   1335 C  CA   . GLY   A 1 189 ? 12.60300  19.55800  14.34400  1.000 17.24571  ?  341 GLY   A CA   1 
ATOM   1336 C  C    . GLY   A 1 189 ? 13.54800  19.41100  13.17000  1.000 29.19089  ?  341 GLY   A C    1 
ATOM   1337 O  O    . GLY   A 1 189 ? 14.70800  19.83100  13.27500  1.000 20.94042  ?  341 GLY   A O    1 
ATOM   1338 N  N    . VAL   A 1 190 ? 13.09700  18.83600  12.05600  1.000 18.16689  ?  342 VAL   A N    1 
ATOM   1339 C  CA   . VAL   A 1 190 ? 13.95800  18.69800  10.88800  1.000 21.73594  ?  342 VAL   A CA   1 
ATOM   1340 C  C    . VAL   A 1 190 ? 14.25700  20.07800  10.31900  1.000 23.13292  ?  342 VAL   A C    1 
ATOM   1341 O  O    . VAL   A 1 190 ? 13.35000  20.89700  10.12300  1.000 23.37825  ?  342 VAL   A O    1 
ATOM   1342 C  CB   . VAL   A 1 190 ? 13.30200  17.78900  9.83800   1.000 21.14760  ?  342 VAL   A CB   1 
ATOM   1343 C  CG1  . VAL   A 1 190 ? 14.09800  17.81000  8.53300   1.000 22.94613  ?  342 VAL   A CG1  1 
ATOM   1344 C  CG2  . VAL   A 1 190 ? 13.18300  16.36500  10.36900  1.000 20.67763  ?  342 VAL   A CG2  1 
ATOM   1345 N  N    . GLN   A 1 191 ? 15.53600  20.35000  10.06200  1.000 19.64442  ?  343 GLN   A N    1 
ATOM   1346 C  CA   . GLN   A 1 191 ? 15.91700  21.62500  9.46500   1.000 27.08552  ?  343 GLN   A CA   1 
ATOM   1347 C  C    . GLN   A 1 191 ? 15.95300  21.55300  7.93900   1.000 30.03197  ?  343 GLN   A C    1 
ATOM   1348 O  O    . GLN   A 1 191 ? 15.34100  22.38800  7.26500   1.000 25.46788  ?  343 GLN   A O    1 
ATOM   1349 C  CB   . GLN   A 1 191 ? 17.27400  22.08200  10.01100  1.000 25.77810  ?  343 GLN   A CB   1 
ATOM   1350 C  CG   . GLN   A 1 191 ? 17.29600  22.31500  11.51900  1.000 35.08994  ?  343 GLN   A CG   1 
ATOM   1351 C  CD   . GLN   A 1 191 ? 16.30000  23.36900  11.97100  1.000 52.12625  ?  343 GLN   A CD   1 
ATOM   1352 O  OE1  . GLN   A 1 191 ? 16.36100  24.52300  11.54500  1.000 48.79067  ?  343 GLN   A OE1  1 
ATOM   1353 N  NE2  . GLN   A 1 191 ? 15.37700  22.97600  12.84500  1.000 49.58537  ?  343 GLN   A NE2  1 
ATOM   1354 N  N    . ASP   A 1 192 ? 16.65400  20.56400  7.37900   1.000 18.10861  ?  344 ASP   A N    1 
ATOM   1355 C  CA   . ASP   A 1 192 ? 16.79100  20.43400  5.92400   1.000 17.98180  ?  344 ASP   A CA   1 
ATOM   1356 C  C    . ASP   A 1 192 ? 15.71000  19.50300  5.37300   1.000 16.63715  ?  344 ASP   A C    1 
ATOM   1357 O  O    . ASP   A 1 192 ? 15.98100  18.42100  4.84900   1.000 16.09205  ?  344 ASP   A O    1 
ATOM   1358 C  CB   . ASP   A 1 192 ? 18.18300  19.93300  5.55700   1.000 17.41070  ?  344 ASP   A CB   1 
ATOM   1359 C  CG   . ASP   A 1 192 ? 19.24000  21.00600  5.68700   1.000 31.86241  ?  344 ASP   A CG   1 
ATOM   1360 O  OD1  . ASP   A 1 192 ? 18.95000  22.15400  5.29900   1.000 34.85111  ?  344 ASP   A OD1  1 
ATOM   1361 O  OD2  . ASP   A 1 192 ? 20.35600  20.70400  6.16100   1.000 27.58059  ?  344 ASP   A OD2  1 
ATOM   1362 N  N    . ALA   A 1 193 ? 14.46100  19.97100  5.47000   1.000 16.63494  ?  345 ALA   A N    1 
ATOM   1363 C  CA   . ALA   A 1 193 ? 13.32400  19.15500  5.04100   1.000 19.94365  ?  345 ALA   A CA   1 
ATOM   1364 C  C    . ALA   A 1 193 ? 13.39400  18.82700  3.55400   1.000 14.95436  ?  345 ALA   A C    1 
ATOM   1365 O  O    . ALA   A 1 193 ? 13.02100  17.72400  3.13700   1.000 15.34123  ?  345 ALA   A O    1 
ATOM   1366 C  CB   . ALA   A 1 193 ? 12.01000  19.86700  5.36600   1.000 13.29458  ?  345 ALA   A CB   1 
ATOM   1367 N  N    . LYS   A 1 194 ? 13.86500  19.77300  2.73700   1.000 13.62495  ?  346 LYS   A N    1 
ATOM   1368 C  CA   . LYS   A 1 194 ? 13.97500  19.52800  1.30100   1.000 19.53463  ?  346 LYS   A CA   1 
ATOM   1369 C  C    . LYS   A 1 194 ? 14.97900  18.42100  1.00100   1.000 18.12122  ?  346 LYS   A C    1 
ATOM   1370 O  O    . LYS   A 1 194 ? 14.76500  17.60700  0.09300   1.000 16.85329  ?  346 LYS   A O    1 
ATOM   1371 C  CB   . LYS   A 1 194 ? 14.37200  20.81300  0.57200   1.000 22.60191  ?  346 LYS   A CB   1 
ATOM   1372 C  CG   . LYS   A 1 194 ? 13.37700  21.95500  0.71200   1.000 30.52043  ?  346 LYS   A CG   1 
ATOM   1373 C  CD   . LYS   A 1 194 ? 12.17400  21.76400  -0.18900  1.000 38.95586  ?  346 LYS   A CD   1 
ATOM   1374 C  CE   . LYS   A 1 194 ? 11.05700  22.72700  0.18300   1.000 49.31923  ?  346 LYS   A CE   1 
ATOM   1375 N  NZ   . LYS   A 1 194 ? 9.74000   22.28100  -0.35200  1.000 44.88316  ?  346 LYS   A NZ   1 
ATOM   1376 N  N    . LEU   A 1 195 ? 16.09400  18.38800  1.73600   1.000 12.85678  ?  347 LEU   A N    1 
ATOM   1377 C  CA   . LEU   A 1 195 ? 17.07800  17.32900  1.52500   1.000 12.81868  ?  347 LEU   A CA   1 
ATOM   1378 C  C    . LEU   A 1 195 ? 16.52600  15.98000  1.96600   1.000 11.03612  ?  347 LEU   A C    1 
ATOM   1379 O  O    . LEU   A 1 195 ? 16.72100  14.97000  1.28200   1.000 15.36085  ?  347 LEU   A O    1 
ATOM   1380 C  CB   . LEU   A 1 195 ? 18.37300  17.64200  2.27900   1.000 15.07434  ?  347 LEU   A CB   1 
ATOM   1381 C  CG   . LEU   A 1 195 ? 19.17700  18.87200  1.84900   1.000 19.34386  ?  347 LEU   A CG   1 
ATOM   1382 C  CD1  . LEU   A 1 195 ? 20.40700  19.01400  2.72200   1.000 18.00100  ?  347 LEU   A CD1  1 
ATOM   1383 C  CD2  . LEU   A 1 195 ? 19.57500  18.78000  0.37800   1.000 17.23276  ?  347 LEU   A CD2  1 
ATOM   1384 N  N    . VAL   A 1 196 ? 15.83700  15.94500  3.11100   1.000 11.44948  ?  348 VAL   A N    1 
ATOM   1385 C  CA   . VAL   A 1 196 ? 15.18100  14.71600  3.55200   1.000 9.95635   ?  348 VAL   A CA   1 
ATOM   1386 C  C    . VAL   A 1 196 ? 14.16500  14.25500  2.51400   1.000 14.04427  ?  348 VAL   A C    1 
ATOM   1387 O  O    . VAL   A 1 196 ? 14.07900  13.06500  2.18400   1.000 15.23262  ?  348 VAL   A O    1 
ATOM   1388 C  CB   . VAL   A 1 196 ? 14.52900  14.93300  4.93100   1.000 11.07711  ?  348 VAL   A CB   1 
ATOM   1389 C  CG1  . VAL   A 1 196 ? 13.79500  13.68800  5.38900   1.000 13.04336  ?  348 VAL   A CG1  1 
ATOM   1390 C  CG2  . VAL   A 1 196 ? 15.58100  15.34600  5.96100   1.000 12.03574  ?  348 VAL   A CG2  1 
ATOM   1391 N  N    . GLU   A 1 197 ? 13.38700  15.19300  1.97300   1.000 12.84607  ?  349 GLU   A N    1 
ATOM   1392 C  CA   . GLU   A 1 197 ? 12.38000  14.83700  0.97900   1.000 18.60354  ?  349 GLU   A CA   1 
ATOM   1393 C  C    . GLU   A 1 197 ? 13.02400  14.28200  -0.28400  1.000 13.30724  ?  349 GLU   A C    1 
ATOM   1394 O  O    . GLU   A 1 197 ? 12.48100  13.37000  -0.92000  1.000 17.93943  ?  349 GLU   A O    1 
ATOM   1395 C  CB   . GLU   A 1 197 ? 11.52300  16.05800  0.65400   1.000 16.40829  ?  349 GLU   A CB   1 
ATOM   1396 C  CG   . GLU   A 1 197 ? 10.40400  15.80200  -0.33800  1.000 17.38464  ?  349 GLU   A CG   1 
ATOM   1397 C  CD   . GLU   A 1 197 ? 9.62100   17.06200  -0.64700  1.000 25.14551  ?  349 GLU   A CD   1 
ATOM   1398 O  OE1  . GLU   A 1 197 ? 10.23600  18.05000  -1.09800  1.000 36.16151  ?  349 GLU   A OE1  1 
ATOM   1399 O  OE2  . GLU   A 1 197 ? 8.39400   17.06700  -0.43400  1.000 39.59728  ?  349 GLU   A OE2  1 
ATOM   1400 N  N    . ALA   A 1 198 ? 14.18200  14.82600  -0.66500  1.000 16.99166  ?  350 ALA   A N    1 
ATOM   1401 C  CA   . ALA   A 1 198 ? 14.87800  14.34300  -1.85400  1.000 20.43775  ?  350 ALA   A CA   1 
ATOM   1402 C  C    . ALA   A 1 198 ? 15.25400  12.87400  -1.71400  1.000 19.91483  ?  350 ALA   A C    1 
ATOM   1403 O  O    . ALA   A 1 198 ? 15.13800  12.10100  -2.67400  1.000 18.85483  ?  350 ALA   A O    1 
ATOM   1404 C  CB   . ALA   A 1 198 ? 16.12000  15.19400  -2.11400  1.000 16.65868  ?  350 ALA   A CB   1 
ATOM   1405 N  N    . ILE   A 1 199 ? 15.69700  12.46800  -0.52200  1.000 16.37124  ?  351 ILE   A N    1 
ATOM   1406 C  CA   . ILE   A 1 199 ? 16.01200  11.06300  -0.28000  1.000 17.59135  ?  351 ILE   A CA   1 
ATOM   1407 C  C    . ILE   A 1 199 ? 14.74500  10.21900  -0.32000  1.000 14.51873  ?  351 ILE   A C    1 
ATOM   1408 O  O    . ILE   A 1 199 ? 14.70000  9.16800   -0.97300  1.000 14.62506  ?  351 ILE   A O    1 
ATOM   1409 C  CB   . ILE   A 1 199 ? 16.74400  10.89400  1.06400   1.000 13.93578  ?  351 ILE   A CB   1 
ATOM   1410 C  CG1  . ILE   A 1 199 ? 17.99600  11.76700  1.12400   1.000 19.21540  ?  351 ILE   A CG1  1 
ATOM   1411 C  CG2  . ILE   A 1 199 ? 17.06800  9.41800   1.31600   1.000 12.42255  ?  351 ILE   A CG2  1 
ATOM   1412 C  CD1  . ILE   A 1 199 ? 18.72300  11.67800  2.45500   1.000 14.12882  ?  351 ILE   A CD1  1 
ATOM   1413 N  N    . GLN   A 1 200 ? 13.70100  10.65600  0.39500   1.000 12.59772  ?  352 GLN   A N    1 
ATOM   1414 C  CA   . GLN   A 1 200 ? 12.47600  9.86500   0.46800   1.000 13.16065  ?  352 GLN   A CA   1 
ATOM   1415 C  C    . GLN   A 1 200 ? 11.85000  9.69300   -0.90600  1.000 15.06125  ?  352 GLN   A C    1 
ATOM   1416 O  O    . GLN   A 1 200 ? 11.34100  8.61300   -1.23200  1.000 14.90599  ?  352 GLN   A O    1 
ATOM   1417 C  CB   . GLN   A 1 200 ? 11.47000  10.50900  1.42400   1.000 15.33058  ?  352 GLN   A CB   1 
ATOM   1418 C  CG   . GLN   A 1 200 ? 10.35400  9.55200   1.85900   1.000 13.14425  ?  352 GLN   A CG   1 
ATOM   1419 C  CD   . GLN   A 1 200 ? 9.23400   10.23200  2.63000   1.000 20.79135  ?  352 GLN   A CD   1 
ATOM   1420 O  OE1  . GLN   A 1 200 ? 8.89000   9.82000   3.74200   1.000 18.30906  ?  352 GLN   A OE1  1 
ATOM   1421 N  NE2  . GLN   A 1 200 ? 8.64800   11.26400  2.03800   1.000 11.91019  ?  352 GLN   A NE2  1 
ATOM   1422 N  N    . ASP   A 1 201 ? 11.87800  10.74900  -1.72300  1.000 12.85558  ?  353 ASP   A N    1 
ATOM   1423 C  CA   . ASP   A 1 201 ? 11.29500  10.67400  -3.05900  1.000 18.09555  ?  353 ASP   A CA   1 
ATOM   1424 C  C    . ASP   A 1 201 ? 11.99500  9.62500   -3.91200  1.000 20.94861  ?  353 ASP   A C    1 
ATOM   1425 O  O    . ASP   A 1 201 ? 11.35000  8.92900   -4.70600  1.000 18.09038  ?  353 ASP   A O    1 
ATOM   1426 C  CB   . ASP   A 1 201 ? 11.35900  12.04400  -3.73700  1.000 14.13477  ?  353 ASP   A CB   1 
ATOM   1427 C  CG   . ASP   A 1 201 ? 10.25300  12.97500  -3.27600  1.000 25.63629  ?  353 ASP   A CG   1 
ATOM   1428 O  OD1  . ASP   A 1 201 ? 9.40700   12.54600  -2.46300  1.000 34.42617  ?  353 ASP   A OD1  1 
ATOM   1429 O  OD2  . ASP   A 1 201 ? 10.23100  14.14000  -3.72400  1.000 38.80391  ?  353 ASP   A OD2  1 
ATOM   1430 N  N    . ARG   A 1 202 ? 13.31800  9.50000   -3.76900  1.000 16.20122  ?  354 ARG   A N    1 
ATOM   1431 C  CA   . ARG   A 1 202 ? 14.04100  8.46600   -4.50300  1.000 22.23302  ?  354 ARG   A CA   1 
ATOM   1432 C  C    . ARG   A 1 202 ? 13.67300  7.07600   -4.00100  1.000 17.55410  ?  354 ARG   A C    1 
ATOM   1433 O  O    . ARG   A 1 202 ? 13.52800  6.14100   -4.79700  1.000 14.74504  ?  354 ARG   A O    1 
ATOM   1434 C  CB   . ARG   A 1 202 ? 15.54700  8.69700   -4.39400  1.000 19.15378  ?  354 ARG   A CB   1 
ATOM   1435 C  CG   . ARG   A 1 202 ? 16.04000  9.90100   -5.18500  1.000 18.33511  ?  354 ARG   A CG   1 
ATOM   1436 C  CD   . ARG   A 1 202 ? 17.55900  9.95500   -5.21100  1.000 33.98191  ?  354 ARG   A CD   1 
ATOM   1437 N  NE   . ARG   A 1 202 ? 18.11000  10.40100  -3.93800  1.000 32.25645  ?  354 ARG   A NE   1 
ATOM   1438 C  CZ   . ARG   A 1 202 ? 18.38500  11.66900  -3.64600  1.000 36.92925  ?  354 ARG   A CZ   1 
ATOM   1439 N  NH1  . ARG   A 1 202 ? 18.16500  12.61800  -4.54300  1.000 26.52192  ?  354 ARG   A NH1  1 
ATOM   1440 N  NH2  . ARG   A 1 202 ? 18.88400  11.98800  -2.45800  1.000 23.22731  ?  354 ARG   A NH2  1 
ATOM   1441 N  N    . LEU   A 1 203 ? 13.53100  6.91900   -2.68200  1.000 12.95006  ?  355 LEU   A N    1 
ATOM   1442 C  CA   . LEU   A 1 203 ? 13.08100  5.64400   -2.13100  1.000 15.80705  ?  355 LEU   A CA   1 
ATOM   1443 C  C    . LEU   A 1 203 ? 11.66000  5.32100   -2.57600  1.000 16.13095  ?  355 LEU   A C    1 
ATOM   1444 O  O    . LEU   A 1 203 ? 11.35800  4.17400   -2.93100  1.000 12.94656  ?  355 LEU   A O    1 
ATOM   1445 C  CB   . LEU   A 1 203 ? 13.16100  5.67800   -0.60500  1.000 14.07869  ?  355 LEU   A CB   1 
ATOM   1446 C  CG   . LEU   A 1 203 ? 14.53200  5.86300   0.04500   1.000 12.05242  ?  355 LEU   A CG   1 
ATOM   1447 C  CD1  . LEU   A 1 203 ? 14.36000  6.02800   1.53900   1.000 15.85442  ?  355 LEU   A CD1  1 
ATOM   1448 C  CD2  . LEU   A 1 203 ? 15.45200  4.69200   -0.24900  1.000 12.97956  ?  355 LEU   A CD2  1 
ATOM   1449 N  N    . SER   A 1 204 ? 10.77000  6.31900   -2.54900  1.000 12.34803  ?  356 SER   A N    1 
ATOM   1450 C  CA   . SER   A 1 204 ? 9.38600   6.09900   -2.96000  1.000 18.28058  ?  356 SER   A CA   1 
ATOM   1451 C  C    . SER   A 1 204 ? 9.29800   5.72800   -4.43300  1.000 15.39563  ?  356 SER   A C    1 
ATOM   1452 O  O    . SER   A 1 204 ? 8.53600   4.83000   -4.80700  1.000 15.50528  ?  356 SER   A O    1 
ATOM   1453 C  CB   . SER   A 1 204 ? 8.54800   7.34800   -2.67800  1.000 19.59063  ?  356 SER   A CB   1 
ATOM   1454 O  OG   . SER   A 1 204 ? 8.30700   7.49300   -1.28600  1.000 34.92237  ?  356 SER   A OG   1 
ATOM   1455 N  N    A ASN   A 1 205 ? 10.06200  6.42100   -5.28400  0.600 16.63236  ?  357 ASN   A N    1 
ATOM   1456 N  N    B ASN   A 1 205 ? 10.06200  6.41300   -5.28900  0.400 16.66988  ?  357 ASN   A N    1 
ATOM   1457 C  CA   A ASN   A 1 205 ? 10.11000  6.08300   -6.70300  0.600 17.78374  ?  357 ASN   A CA   1 
ATOM   1458 C  CA   B ASN   A 1 205 ? 10.07800  6.05900   -6.70600  0.400 17.79243  ?  357 ASN   A CA   1 
ATOM   1459 C  C    A ASN   A 1 205 ? 10.55000  4.63900   -6.90900  0.600 15.63361  ?  357 ASN   A C    1 
ATOM   1460 C  C    B ASN   A 1 205 ? 10.53900  4.62100   -6.90400  0.400 15.67647  ?  357 ASN   A C    1 
ATOM   1461 O  O    A ASN   A 1 205 ? 9.98800   3.91800   -7.74300  0.600 15.31452  ?  357 ASN   A O    1 
ATOM   1462 O  O    B ASN   A 1 205 ? 9.98100   3.88700   -7.72900  0.400 15.32092  ?  357 ASN   A O    1 
ATOM   1463 C  CB   A ASN   A 1 205 ? 11.06000  7.04100   -7.42700  0.600 20.90441  ?  357 ASN   A CB   1 
ATOM   1464 C  CB   B ASN   A 1 205 ? 10.98300  7.01700   -7.47900  0.400 20.96557  ?  357 ASN   A CB   1 
ATOM   1465 C  CG   A ASN   A 1 205 ? 11.00900  6.89300   -8.93400  0.600 27.34962  ?  357 ASN   A CG   1 
ATOM   1466 C  CG   B ASN   A 1 205 ? 10.38100  8.39700   -7.62000  0.400 18.37767  ?  357 ASN   A CG   1 
ATOM   1467 O  OD1  A ASN   A 1 205 ? 11.98400  6.48100   -9.56500  0.600 30.06395  ?  357 ASN   A OD1  1 
ATOM   1468 O  OD1  B ASN   A 1 205 ? 9.18600   8.59000   -7.40000  0.400 29.86415  ?  357 ASN   A OD1  1 
ATOM   1469 N  ND2  A ASN   A 1 205 ? 9.87000   7.24000   -9.52300  0.600 24.47633  ?  357 ASN   A ND2  1 
ATOM   1470 N  ND2  B ASN   A 1 205 ? 11.20700  9.36800   -7.99100  0.400 33.35269  ?  357 ASN   A ND2  1 
ATOM   1471 N  N    . THR   A 1 206 ? 11.55400  4.20200   -6.14900  1.000 13.45902  ?  358 THR   A N    1 
ATOM   1472 C  CA   . THR   A 1 206 ? 12.04700  2.83600   -6.25700  1.000 12.31897  ?  358 THR   A CA   1 
ATOM   1473 C  C    . THR   A 1 206 ? 10.99600  1.82900   -5.80500  1.000 16.71825  ?  358 THR   A C    1 
ATOM   1474 O  O    . THR   A 1 206 ? 10.83400  0.77100   -6.42700  1.000 19.53826  ?  358 THR   A O    1 
ATOM   1475 C  CB   . THR   A 1 206 ? 13.32100  2.70000   -5.42500  1.000 14.53945  ?  358 THR   A CB   1 
ATOM   1476 O  OG1  . THR   A 1 206 ? 14.27600  3.66800   -5.87400  1.000 16.04355  ?  358 THR   A OG1  1 
ATOM   1477 C  CG2  . THR   A 1 206 ? 13.90600  1.30300   -5.54200  1.000 15.24030  ?  358 THR   A CG2  1 
ATOM   1478 N  N    . LEU   A 1 207 ? 10.27300  2.13900   -4.72600  1.000 13.14828  ?  359 LEU   A N    1 
ATOM   1479 C  CA   . LEU   A 1 207 ? 9.21400   1.24700   -4.26300  1.000 14.82008  ?  359 LEU   A CA   1 
ATOM   1480 C  C    . LEU   A 1 207 ? 8.09400   1.14400   -5.29100  1.000 15.43730  ?  359 LEU   A C    1 
ATOM   1481 O  O    . LEU   A 1 207 ? 7.61000   0.04600   -5.59200  1.000 14.33133  ?  359 LEU   A O    1 
ATOM   1482 C  CB   . LEU   A 1 207 ? 8.66300   1.73100   -2.91900  1.000 14.30256  ?  359 LEU   A CB   1 
ATOM   1483 C  CG   . LEU   A 1 207 ? 7.53600   0.88800   -2.31600  1.000 14.86927  ?  359 LEU   A CG   1 
ATOM   1484 C  CD1  . LEU   A 1 207 ? 7.97100   -0.56300  -2.15900  1.000 16.43199  ?  359 LEU   A CD1  1 
ATOM   1485 C  CD2  . LEU   A 1 207 ? 7.06800   1.47000   -0.98400  1.000 12.30181  ?  359 LEU   A CD2  1 
ATOM   1486 N  N    . GLN   A 1 208 ? 7.66300   2.28500   -5.83700  1.000 14.89018  ?  360 GLN   A N    1 
ATOM   1487 C  CA   . GLN   A 1 208 ? 6.59100   2.26500   -6.82900  1.000 16.37037  ?  360 GLN   A CA   1 
ATOM   1488 C  C    . GLN   A 1 208 ? 6.99500   1.46200   -8.05800  1.000 21.88482  ?  360 GLN   A C    1 
ATOM   1489 O  O    . GLN   A 1 208 ? 6.19400   0.68500   -8.59400  1.000 21.42695  ?  360 GLN   A O    1 
ATOM   1490 C  CB   . GLN   A 1 208 ? 6.20600   3.69200   -7.22300  1.000 19.08835  ?  360 GLN   A CB   1 
ATOM   1491 C  CG   . GLN   A 1 208 ? 5.55800   4.49400   -6.10300  1.000 25.98148  ?  360 GLN   A CG   1 
ATOM   1492 C  CD   . GLN   A 1 208 ? 5.55400   5.98600   -6.38100  1.000 43.90600  ?  360 GLN   A CD   1 
ATOM   1493 O  OE1  . GLN   A 1 208 ? 5.68800   6.79900   -5.46700  1.000 35.23497  ?  360 GLN   A OE1  1 
ATOM   1494 N  NE2  . GLN   A 1 208 ? 5.39900   6.35200   -7.64800  1.000 45.91959  ?  360 GLN   A NE2  1 
ATOM   1495 N  N    . THR   A 1 209 ? 8.23600   1.62900   -8.51800  1.000 19.67645  ?  361 THR   A N    1 
ATOM   1496 C  CA   . THR   A 1 209 ? 8.69100   0.87300   -9.68100  1.000 20.77905  ?  361 THR   A CA   1 
ATOM   1497 C  C    . THR   A 1 209 ? 8.79400   -0.61400  -9.36800  1.000 20.90344  ?  361 THR   A C    1 
ATOM   1498 O  O    . THR   A 1 209 ? 8.43600   -1.45400  -10.20300 1.000 20.69798  ?  361 THR   A O    1 
ATOM   1499 C  CB   . THR   A 1 209 ? 10.03000  1.41500   -10.17300 1.000 20.21215  ?  361 THR   A CB   1 
ATOM   1500 O  OG1  . THR   A 1 209 ? 9.87700   2.79200   -10.53400 1.000 17.35114  ?  361 THR   A OG1  1 
ATOM   1501 C  CG2  . THR   A 1 209 ? 10.51400  0.62700   -11.38300 1.000 20.92243  ?  361 THR   A CG2  1 
ATOM   1502 N  N    . TYR   A 1 210 ? 9.27300   -0.96400  -8.16900  1.000 17.43372  ?  362 TYR   A N    1 
ATOM   1503 C  CA   . TYR   A 1 210 ? 9.33100   -2.37400  -7.79600  1.000 15.68874  ?  362 TYR   A CA   1 
ATOM   1504 C  C    . TYR   A 1 210 ? 7.94100   -2.99900  -7.80000  1.000 22.88833  ?  362 TYR   A C    1 
ATOM   1505 O  O    . TYR   A 1 210 ? 7.75700   -4.12300  -8.28200  1.000 23.05635  ?  362 TYR   A O    1 
ATOM   1506 C  CB   . TYR   A 1 210 ? 9.98700   -2.54700  -6.42300  1.000 15.95465  ?  362 TYR   A CB   1 
ATOM   1507 C  CG   . TYR   A 1 210 ? 10.11500  -4.00400  -6.02700  1.000 21.39035  ?  362 TYR   A CG   1 
ATOM   1508 C  CD1  . TYR   A 1 210 ? 9.08200   -4.66200  -5.36200  1.000 23.59960  ?  362 TYR   A CD1  1 
ATOM   1509 C  CD2  . TYR   A 1 210 ? 11.25000  -4.73100  -6.35200  1.000 19.09215  ?  362 TYR   A CD2  1 
ATOM   1510 C  CE1  . TYR   A 1 210 ? 9.18900   -5.99800  -5.02100  1.000 23.64219  ?  362 TYR   A CE1  1 
ATOM   1511 C  CE2  . TYR   A 1 210 ? 11.36700  -6.06400  -6.01200  1.000 21.61688  ?  362 TYR   A CE2  1 
ATOM   1512 C  CZ   . TYR   A 1 210 ? 10.33600  -6.69200  -5.34700  1.000 25.74489  ?  362 TYR   A CZ   1 
ATOM   1513 O  OH   . TYR   A 1 210 ? 10.45200  -8.02100  -5.00900  1.000 29.58861  ?  362 TYR   A OH   1 
ATOM   1514 N  N    . ILE   A 1 211 ? 6.95000   -2.28100  -7.27000  1.000 17.23474  ?  363 ILE   A N    1 
ATOM   1515 C  CA   . ILE   A 1 211 ? 5.58300   -2.79500  -7.24800  1.000 20.38552  ?  363 ILE   A CA   1 
ATOM   1516 C  C    . ILE   A 1 211 ? 5.06500   -3.01500  -8.66600  1.000 20.91277  ?  363 ILE   A C    1 
ATOM   1517 O  O    . ILE   A 1 211 ? 4.42000   -4.03200  -8.95800  1.000 22.88532  ?  363 ILE   A O    1 
ATOM   1518 C  CB   . ILE   A 1 211 ? 4.67800   -1.84200  -6.44400  1.000 16.16838  ?  363 ILE   A CB   1 
ATOM   1519 C  CG1  . ILE   A 1 211 ? 5.03100   -1.91200  -4.95200  1.000 16.00068  ?  363 ILE   A CG1  1 
ATOM   1520 C  CG2  . ILE   A 1 211 ? 3.20200   -2.15600  -6.68700  1.000 17.95972  ?  363 ILE   A CG2  1 
ATOM   1521 C  CD1  . ILE   A 1 211 ? 4.35000   -0.85400  -4.10100  1.000 17.54734  ?  363 ILE   A CD1  1 
ATOM   1522 N  N    . ARG   A 1 212 ? 5.37500   -2.09000  -9.56200  1.000 21.28388  ?  364 ARG   A N    1 
ATOM   1523 C  CA   . ARG   A 1 212 ? 4.88600   -2.18600  -10.95700 1.000 24.02441  ?  364 ARG   A CA   1 
ATOM   1524 C  C    . ARG   A 1 212 ? 5.54200   -3.37100  -11.66300 1.000 34.29087  ?  364 ARG   A C    1 
ATOM   1525 O  O    . ARG   A 1 212 ? 4.95000   -3.88600  -12.57800 1.000 28.03537  ?  364 ARG   A O    1 
ATOM   1526 C  CB   . ARG   A 1 212 ? 5.12400   -0.89700  -11.73100 1.000 28.80302  ?  364 ARG   A CB   1 
ATOM   1527 C  CG   . ARG   A 1 212 ? 4.16000   0.21700   -11.37600 1.000 33.75515  ?  364 ARG   A CG   1 
ATOM   1528 C  CD   . ARG   A 1 212 ? 4.09800   1.25400   -12.48900 1.000 51.70928  ?  364 ARG   A CD   1 
ATOM   1529 N  NE   . ARG   A 1 212 ? 5.40900   1.79700   -12.78200 1.000 49.19656  ?  364 ARG   A NE   1 
ATOM   1530 C  CZ   . ARG   A 1 212 ? 5.95400   2.79600   -12.11800 1.000 60.34725  ?  364 ARG   A CZ   1 
ATOM   1531 N  NH1  . ARG   A 1 212 ? 7.16900   3.20500   -12.42600 1.000 51.61637  ?  364 ARG   A NH1  1 
ATOM   1532 N  NH2  . ARG   A 1 212 ? 5.28800   3.37900   -11.14300 1.000 48.56734  ?  364 ARG   A NH2  1 
ATOM   1533 N  N    . CYS   A 1 213 ? 6.74900   -3.73200  -11.26200 1.000 24.28644  ?  365 CYS   A N    1 
ATOM   1534 C  CA   . CYS   A 1 213 ? 7.40900   -4.88000  -11.87300 1.000 28.92256  ?  365 CYS   A CA   1 
ATOM   1535 C  C    . CYS   A 1 213 ? 6.74300   -6.18400  -11.46300 1.000 32.44971  ?  365 CYS   A C    1 
ATOM   1536 O  O    . CYS   A 1 213 ? 6.75400   -7.15300  -12.23100 1.000 38.59500  ?  365 CYS   A O    1 
ATOM   1537 C  CB   . CYS   A 1 213 ? 8.88900   -4.91200  -11.49400 1.000 24.06193  ?  365 CYS   A CB   1 
ATOM   1538 S  SG   . CYS   A 1 213 ? 9.88400   -3.60800  -12.24400 1.000 33.53913  ?  365 CYS   A SG   1 
ATOM   1539 N  N    . ARG   A 1 214 ? 6.14200   -6.19100  -10.28600 1.000 33.86668  ?  366 ARG   A N    1 
ATOM   1540 C  CA   . ARG   A 1 214 ? 5.52700   -7.43400  -9.78100  1.000 31.16946  ?  366 ARG   A CA   1 
ATOM   1541 C  C    . ARG   A 1 214 ? 4.02700   -7.48100  -10.06200 1.000 30.31540  ?  366 ARG   A C    1 
ATOM   1542 O  O    . ARG   A 1 214 ? 3.51700   -8.57600  -10.17800 1.000 36.58962  ?  366 ARG   A O    1 
ATOM   1543 C  CB   . ARG   A 1 214 ? 5.72600   -7.53200  -8.27000  1.000 33.10425  ?  366 ARG   A CB   1 
ATOM   1544 C  CG   . ARG   A 1 214 ? 7.16700   -7.46300  -7.80000  1.000 33.48777  ?  366 ARG   A CG   1 
ATOM   1545 C  CD   . ARG   A 1 214 ? 8.06100   -8.54300  -8.33400  1.000 33.55199  ?  366 ARG   A CD   1 
ATOM   1546 N  NE   . ARG   A 1 214 ? 7.55100   -9.85500  -8.03700  1.000 49.29863  ?  366 ARG   A NE   1 
ATOM   1547 C  CZ   . ARG   A 1 214 ? 8.27300   -10.96400 -8.07600  1.000 54.98821  ?  366 ARG   A CZ   1 
ATOM   1548 N  NH1  . ARG   A 1 214 ? 9.54900   -10.90500 -8.39400  1.000 52.32249  ?  366 ARG   A NH1  1 
ATOM   1549 N  NH2  . ARG   A 1 214 ? 7.71600   -12.12200 -7.80300  1.000 50.85736  ?  366 ARG   A NH2  1 
ATOM   1550 N  N    . HIS   A 1 215 ? 3.37000   -6.34100  -10.20100 1.000 26.38670  ?  367 HIS   A N    1 
ATOM   1551 C  CA   . HIS   A 1 215 ? 1.91000   -6.31600  -10.28000 1.000 30.10366  ?  367 HIS   A CA   1 
ATOM   1552 C  C    . HIS   A 1 215 ? 1.40700   -5.35200  -11.34800 1.000 28.54775  ?  367 HIS   A C    1 
ATOM   1553 O  O    . HIS   A 1 215 ? 1.81100   -4.17400  -11.35900 1.000 23.30427  ?  367 HIS   A O    1 
ATOM   1554 C  CB   . HIS   A 1 215 ? 1.30500   -5.94100  -8.92300  1.000 23.55705  ?  367 HIS   A CB   1 
ATOM   1555 C  CG   . HIS   A 1 215 ? 1.81600   -6.76300  -7.78300  1.000 33.80601  ?  367 HIS   A CG   1 
ATOM   1556 N  ND1  . HIS   A 1 215 ? 1.40500   -8.05900  -7.55800  1.000 38.40573  ?  367 HIS   A ND1  1 
ATOM   1557 C  CD2  . HIS   A 1 215 ? 2.70000   -6.47100  -6.79900  1.000 31.82851  ?  367 HIS   A CD2  1 
ATOM   1558 C  CE1  . HIS   A 1 215 ? 2.01700   -8.53200  -6.48700  1.000 41.83711  ?  367 HIS   A CE1  1 
ATOM   1559 N  NE2  . HIS   A 1 215 ? 2.80900   -7.58900  -6.00800  1.000 31.78500  ?  367 HIS   A NE2  1 
ATOM   1560 N  N    . PRO   A 1 216 ? 0.52300   -5.80200  -12.23400 1.000 28.88824  ?  368 PRO   A N    1 
ATOM   1561 C  CA   . PRO   A 1 216 ? -0.11800  -4.88900  -13.17800 1.000 32.38060  ?  368 PRO   A CA   1 
ATOM   1562 C  C    . PRO   A 1 216 ? -1.16900  -4.04800  -12.47700 1.000 29.69576  ?  368 PRO   A C    1 
ATOM   1563 O  O    . PRO   A 1 216 ? -1.59000  -4.37700  -11.35700 1.000 26.25272  ?  368 PRO   A O    1 
ATOM   1564 C  CB   . PRO   A 1 216 ? -0.76100  -5.84000  -14.19900 1.000 29.68865  ?  368 PRO   A CB   1 
ATOM   1565 C  CG   . PRO   A 1 216 ? -1.05600  -7.06100  -13.40600 1.000 34.59779  ?  368 PRO   A CG   1 
ATOM   1566 C  CD   . PRO   A 1 216 ? 0.08100   -7.19400  -12.42400 1.000 32.92141  ?  368 PRO   A CD   1 
ATOM   1567 N  N    . PRO   A 1 217 ? -1.61600  -2.95100  -13.09300 1.000 21.34227  ?  369 PRO   A N    1 
ATOM   1568 C  CA   . PRO   A 1 217 ? -2.73300  -2.20900  -12.52000 1.000 24.47303  ?  369 PRO   A CA   1 
ATOM   1569 C  C    . PRO   A 1 217 ? -4.01600  -3.00600  -12.65500 1.000 28.44717  ?  369 PRO   A C    1 
ATOM   1570 O  O    . PRO   A 1 217 ? -4.15200  -3.83700  -13.57100 1.000 27.17799  ?  369 PRO   A O    1 
ATOM   1571 C  CB   . PRO   A 1 217 ? -2.77600  -0.92300  -13.36500 1.000 29.58617  ?  369 PRO   A CB   1 
ATOM   1572 C  CG   . PRO   A 1 217 ? -2.13400  -1.28600  -14.65500 1.000 35.08769  ?  369 PRO   A CG   1 
ATOM   1573 C  CD   . PRO   A 1 217 ? -1.12700  -2.36000  -14.35300 1.000 24.87042  ?  369 PRO   A CD   1 
ATOM   1574 N  N    . PRO   A 1 218 ? -4.99400  -2.79400  -11.75900 1.000 29.41593  ?  370 PRO   A N    1 
ATOM   1575 C  CA   . PRO   A 1 218 ? -4.96000  -1.83200  -10.65100 1.000 23.61427  ?  370 PRO   A CA   1 
ATOM   1576 C  C    . PRO   A 1 218 ? -4.38300  -2.38800  -9.34900  1.000 23.84261  ?  370 PRO   A C    1 
ATOM   1577 O  O    . PRO   A 1 218 ? -4.34200  -1.64800  -8.36300  1.000 23.61443  ?  370 PRO   A O    1 
ATOM   1578 C  CB   . PRO   A 1 218 ? -6.43500  -1.47700  -10.46700 1.000 28.08823  ?  370 PRO   A CB   1 
ATOM   1579 C  CG   . PRO   A 1 218 ? -7.15800  -2.73700  -10.83100 1.000 26.58807  ?  370 PRO   A CG   1 
ATOM   1580 C  CD   . PRO   A 1 218 ? -6.30300  -3.46700  -11.85500 1.000 25.56987  ?  370 PRO   A CD   1 
ATOM   1581 N  N    . GLY   A 1 219 ? -3.95600  -3.65500  -9.33900  1.000 18.07483  ?  371 GLY   A N    1 
ATOM   1582 C  CA   . GLY   A 1 219 ? -3.37700  -4.21400  -8.12800  1.000 19.78047  ?  371 GLY   A CA   1 
ATOM   1583 C  C    . GLY   A 1 219 ? -2.13700  -3.46300  -7.68400  1.000 27.74327  ?  371 GLY   A C    1 
ATOM   1584 O  O    . GLY   A 1 219 ? -1.87800  -3.32200  -6.48800  1.000 18.78149  ?  371 GLY   A O    1 
ATOM   1585 N  N    . SER   A 1 220 ? -1.35100  -2.97600  -8.64500  1.000 19.65929  ?  372 SER   A N    1 
ATOM   1586 C  CA   . SER   A 1 220 ? -0.22200  -2.10300  -8.33600  1.000 24.19766  ?  372 SER   A CA   1 
ATOM   1587 C  C    . SER   A 1 220 ? -0.66800  -0.93100  -7.47800  1.000 25.10572  ?  372 SER   A C    1 
ATOM   1588 O  O    . SER   A 1 220 ? -0.11400  -0.68900  -6.39600  1.000 20.32304  ?  372 SER   A O    1 
ATOM   1589 C  CB   . SER   A 1 220 ? 0.40400   -1.59100  -9.62900  1.000 20.55391  ?  372 SER   A CB   1 
ATOM   1590 O  OG   . SER   A 1 220 ? -0.55800  -0.92100  -10.41900 1.000 26.40495  ?  372 SER   A OG   1 
ATOM   1591 N  N    . HIS   A 1 221 ? -1.69100  -0.19900  -7.94400  1.000 22.90244  ?  373 HIS   A N    1 
ATOM   1592 C  CA   . HIS   A 1 221 ? -2.14000  1.00400   -7.24700  1.000 29.53175  ?  373 HIS   A CA   1 
ATOM   1593 C  C    . HIS   A 1 221 ? -2.72400  0.67400   -5.88100  1.000 28.78297  ?  373 HIS   A C    1 
ATOM   1594 O  O    . HIS   A 1 221 ? -2.51100  1.41400   -4.91300  1.000 23.99088  ?  373 HIS   A O    1 
ATOM   1595 C  CB   . HIS   A 1 221 ? -3.18000  1.74000   -8.08400  1.000 30.56143  ?  373 HIS   A CB   1 
ATOM   1596 C  CG   . HIS   A 1 221 ? -2.72400  2.05200   -9.46800  1.000 34.41401  ?  373 HIS   A CG   1 
ATOM   1597 N  ND1  . HIS   A 1 221 ? -1.46500  2.53900   -9.73800  1.000 40.71249  ?  373 HIS   A ND1  1 
ATOM   1598 C  CD2  . HIS   A 1 221 ? -3.33900  1.90900   -10.66500 1.000 40.40239  ?  373 HIS   A CD2  1 
ATOM   1599 C  CE1  . HIS   A 1 221 ? -1.33000  2.70100   -11.04000 1.000 41.19648  ?  373 HIS   A CE1  1 
ATOM   1600 N  NE2  . HIS   A 1 221 ? -2.45100  2.32400   -11.62700 1.000 38.81407  ?  373 HIS   A NE2  1 
ATOM   1601 N  N    . GLN   A 1 222 ? -3.47900  -0.42300  -5.78500  1.000 20.17748  ?  374 GLN   A N    1 
ATOM   1602 C  CA   . GLN   A 1 222 ? -4.12100  -0.76300  -4.52000  1.000 26.43779  ?  374 GLN   A CA   1 
ATOM   1603 C  C    . GLN   A 1 222 ? -3.08900  -1.13800  -3.46300  1.000 23.50139  ?  374 GLN   A C    1 
ATOM   1604 O  O    . GLN   A 1 222 ? -3.21600  -0.74300  -2.29900  1.000 21.00415  ?  374 GLN   A O    1 
ATOM   1605 C  CB   . GLN   A 1 222 ? -5.13200  -1.89300  -4.73300  1.000 23.13972  ?  374 GLN   A CB   1 
ATOM   1606 C  CG   . GLN   A 1 222 ? -6.20600  -1.56100  -5.77000  1.000 22.89512  ?  374 GLN   A CG   1 
ATOM   1607 C  CD   . GLN   A 1 222 ? -7.00500  -2.77500  -6.22000  1.000 24.84099  ?  374 GLN   A CD   1 
ATOM   1608 O  OE1  . GLN   A 1 222 ? -6.64200  -3.91500  -5.93400  1.000 25.30759  ?  374 GLN   A OE1  1 
ATOM   1609 N  NE2  . GLN   A 1 222 ? -8.10000  -2.53100  -6.92900  1.000 33.75070  ?  374 GLN   A NE2  1 
ATOM   1610 N  N    . LEU   A 1 223 ? -2.04900  -1.88100  -3.85400  1.000 25.38179  ?  375 LEU   A N    1 
ATOM   1611 C  CA   . LEU   A 1 223 ? -1.01400  -2.27000  -2.90000  1.000 24.17282  ?  375 LEU   A CA   1 
ATOM   1612 C  C    . LEU   A 1 223 ? -0.24700  -1.05500  -2.39100  1.000 28.38087  ?  375 LEU   A C    1 
ATOM   1613 O  O    . LEU   A 1 223 ? -0.01700  -0.91600  -1.18400  1.000 24.51268  ?  375 LEU   A O    1 
ATOM   1614 C  CB   . LEU   A 1 223 ? -0.05700  -3.27600  -3.53800  1.000 19.75179  ?  375 LEU   A CB   1 
ATOM   1615 C  CG   . LEU   A 1 223 ? 1.15700   -3.63800  -2.67100  1.000 21.11714  ?  375 LEU   A CG   1 
ATOM   1616 C  CD1  . LEU   A 1 223 ? 0.72500   -4.22500  -1.32800  1.000 23.50783  ?  375 LEU   A CD1  1 
ATOM   1617 C  CD2  . LEU   A 1 223 ? 2.09700   -4.58400  -3.40200  1.000 20.14935  ?  375 LEU   A CD2  1 
ATOM   1618 N  N    . TYR   A 1 224 ? 0.16800   -0.16800  -3.30100  1.000 22.22468  ?  376 TYR   A N    1 
ATOM   1619 C  CA   . TYR   A 1 224 ? 0.89500   1.02600   -2.88100  1.000 21.67963  ?  376 TYR   A CA   1 
ATOM   1620 C  C    . TYR   A 1 224 ? 0.04500   1.89200   -1.96000  1.000 26.31415  ?  376 TYR   A C    1 
ATOM   1621 O  O    . TYR   A 1 224 ? 0.55400   2.45500   -0.98300  1.000 23.46118  ?  376 TYR   A O    1 
ATOM   1622 C  CB   . TYR   A 1 224 ? 1.34900   1.83200   -4.09700  1.000 23.07430  ?  376 TYR   A CB   1 
ATOM   1623 C  CG   . TYR   A 1 224 ? 2.23500   3.00800   -3.73800  1.000 21.83252  ?  376 TYR   A CG   1 
ATOM   1624 C  CD1  . TYR   A 1 224 ? 3.40800   2.82400   -3.01600  1.000 24.40425  ?  376 TYR   A CD1  1 
ATOM   1625 C  CD2  . TYR   A 1 224 ? 1.89200   4.30100   -4.11000  1.000 24.17180  ?  376 TYR   A CD2  1 
ATOM   1626 C  CE1  . TYR   A 1 224 ? 4.22100   3.89600   -2.67900  1.000 24.30463  ?  376 TYR   A CE1  1 
ATOM   1627 C  CE2  . TYR   A 1 224 ? 2.69600   5.38100   -3.77800  1.000 26.06319  ?  376 TYR   A CE2  1 
ATOM   1628 C  CZ   . TYR   A 1 224 ? 3.86000   5.17100   -3.06300  1.000 31.09629  ?  376 TYR   A CZ   1 
ATOM   1629 O  OH   . TYR   A 1 224 ? 4.66600   6.23700   -2.73200  1.000 31.62074  ?  376 TYR   A OH   1 
ATOM   1630 N  N    . ALA   A 1 225 ? -1.25200  2.01000   -2.25700  1.000 21.84993  ?  377 ALA   A N    1 
ATOM   1631 C  CA   . ALA   A 1 225 ? -2.14100  2.78100   -1.39500  1.000 30.79085  ?  377 ALA   A CA   1 
ATOM   1632 C  C    . ALA   A 1 225 ? -2.20900  2.17900   0.00200   1.000 30.37456  ?  377 ALA   A C    1 
ATOM   1633 O  O    . ALA   A 1 225 ? -2.19100  2.90700   1.00200   1.000 26.82692  ?  377 ALA   A O    1 
ATOM   1634 C  CB   . ALA   A 1 225 ? -3.53500  2.86200   -2.01500  1.000 29.08185  ?  377 ALA   A CB   1 
ATOM   1635 N  N    . LYS   A 1 226 ? -2.28000  0.84700   0.09200   1.000 23.94597  ?  378 LYS   A N    1 
ATOM   1636 C  CA   . LYS   A 1 226 ? -2.31000  0.19800   1.39900   1.000 22.36674  ?  378 LYS   A CA   1 
ATOM   1637 C  C    . LYS   A 1 226 ? -0.99900  0.39400   2.15100   1.000 24.28135  ?  378 LYS   A C    1 
ATOM   1638 O  O    . LYS   A 1 226 ? -1.00300  0.50300   3.38300   1.000 24.91063  ?  378 LYS   A O    1 
ATOM   1639 C  CB   . LYS   A 1 226 ? -2.61500  -1.29300  1.24200   1.000 23.68569  ?  378 LYS   A CB   1 
ATOM   1640 C  CG   . LYS   A 1 226 ? -4.02500  -1.58900  0.74700   1.000 26.86821  ?  378 LYS   A CG   1 
ATOM   1641 C  CD   . LYS   A 1 226 ? -4.22600  -3.07500  0.48800   1.000 30.95453  ?  378 LYS   A CD   1 
ATOM   1642 C  CE   . LYS   A 1 226 ? -5.61000  -3.35100  -0.07900  1.000 39.01604  ?  378 LYS   A CE   1 
ATOM   1643 N  NZ   . LYS   A 1 226 ? -5.91900  -4.80600  -0.11300  1.000 40.82162  ?  378 LYS   A NZ   1 
ATOM   1644 N  N    . MET   A 1 227 ? 0.12800   0.43700   1.43600   1.000 19.05835  ?  379 MET   A N    1 
ATOM   1645 C  CA   . MET   A 1 227 ? 1.40200   0.72600   2.08900   1.000 24.50890  ?  379 MET   A CA   1 
ATOM   1646 C  C    . MET   A 1 227 ? 1.42900   2.15200   2.62400   1.000 23.75989  ?  379 MET   A C    1 
ATOM   1647 O  O    . MET   A 1 227 ? 1.90300   2.39300   3.74100   1.000 22.06217  ?  379 MET   A O    1 
ATOM   1648 C  CB   . MET   A 1 227 ? 2.56200   0.48800   1.11900   1.000 18.09138  ?  379 MET   A CB   1 
ATOM   1649 C  CG   . MET   A 1 227 ? 2.74600   -0.96800  0.72200   1.000 20.28615  ?  379 MET   A CG   1 
ATOM   1650 S  SD   . MET   A 1 227 ? 4.12700   -1.24900  -0.40900  1.000 22.50048  ?  379 MET   A SD   1 
ATOM   1651 C  CE   . MET   A 1 227 ? 5.47800   -1.53200  0.73600   1.000 27.51396  ?  379 MET   A CE   1 
ATOM   1652 N  N    . ILE   A 1 228 ? 0.91200   3.10400   1.84200   1.000 22.28807  ?  380 ILE   A N    1 
ATOM   1653 C  CA   . ILE   A 1 228 ? 0.80500   4.48800   2.30100   1.000 29.28981  ?  380 ILE   A CA   1 
ATOM   1654 C  C    . ILE   A 1 228 ? -0.02200  4.56000   3.57900   1.000 31.49879  ?  380 ILE   A C    1 
ATOM   1655 O  O    . ILE   A 1 228 ? 0.34800   5.24100   4.54300   1.000 30.47229  ?  380 ILE   A O    1 
ATOM   1656 C  CB   . ILE   A 1 228 ? 0.20000   5.37400   1.19500   1.000 36.74831  ?  380 ILE   A CB   1 
ATOM   1657 C  CG1  . ILE   A 1 228 ? 1.17000   5.53800   0.01800   1.000 30.99964  ?  380 ILE   A CG1  1 
ATOM   1658 C  CG2  . ILE   A 1 228 ? -0.20800  6.73300   1.75500   1.000 38.00373  ?  380 ILE   A CG2  1 
ATOM   1659 C  CD1  . ILE   A 1 228 ? 2.64300   5.45700   0.38700   1.000 43.66805  ?  380 ILE   A CD1  1 
ATOM   1660 N  N    . GLN   A 1 229 ? -1.16000  3.85900   3.60000   1.000 25.65643  ?  381 GLN   A N    1 
ATOM   1661 C  CA   . GLN   A 1 229 ? -2.02100  3.87000   4.77900   1.000 24.77205  ?  381 GLN   A CA   1 
ATOM   1662 C  C    . GLN   A 1 229 ? -1.30500  3.29700   5.99500   1.000 25.06599  ?  381 GLN   A C    1 
ATOM   1663 O  O    . GLN   A 1 229 ? -1.50600  3.76600   7.12200   1.000 22.92575  ?  381 GLN   A O    1 
ATOM   1664 C  CB   . GLN   A 1 229 ? -3.30500  3.08900   4.49800   1.000 29.50193  ?  381 GLN   A CB   1 
ATOM   1665 C  CG   . GLN   A 1 229 ? -4.31900  3.14500   5.63100   1.000 24.99572  ?  381 GLN   A CG   1 
ATOM   1666 C  CD   . GLN   A 1 229 ? -4.77700  4.56100   5.93100   1.000 44.66970  ?  381 GLN   A CD   1 
ATOM   1667 O  OE1  . GLN   A 1 229 ? -4.62400  5.05300   7.05000   1.000 41.25866  ?  381 GLN   A OE1  1 
ATOM   1668 N  NE2  . GLN   A 1 229 ? -5.34400  5.22400   4.92900   1.000 39.29776  ?  381 GLN   A NE2  1 
ATOM   1669 N  N    . LYS   A 1 230 ? -0.47300  2.27200   5.79000   1.000 20.35913  ?  382 LYS   A N    1 
ATOM   1670 C  CA   . LYS   A 1 230 ? 0.26100   1.69300   6.91000   1.000 21.41353  ?  382 LYS   A CA   1 
ATOM   1671 C  C    . LYS   A 1 230 ? 1.26100   2.69000   7.48200   1.000 19.52572  ?  382 LYS   A C    1 
ATOM   1672 O  O    . LYS   A 1 230 ? 1.48000   2.72900   8.69700   1.000 18.27761  ?  382 LYS   A O    1 
ATOM   1673 C  CB   . LYS   A 1 230 ? 0.96100   0.40600   6.47700   1.000 21.59430  ?  382 LYS   A CB   1 
ATOM   1674 C  CG   . LYS   A 1 230 ? 0.00800   -0.77000  6.29600   1.000 27.16228  ?  382 LYS   A CG   1 
ATOM   1675 C  CD   . LYS   A 1 230 ? -0.58300  -1.21000  7.63400   1.000 30.85129  ?  382 LYS   A CD   1 
ATOM   1676 C  CE   . LYS   A 1 230 ? -1.86500  -2.01200  7.44800   1.000 43.81446  ?  382 LYS   A CE   1 
ATOM   1677 N  NZ   . LYS   A 1 230 ? -3.07600  -1.14000  7.38100   1.000 38.82012  ?  382 LYS   A NZ   1 
ATOM   1678 N  N    . LEU   A 1 231 ? 1.87500   3.50500   6.62300   1.000 19.29473  ?  383 LEU   A N    1 
ATOM   1679 C  CA   . LEU   A 1 231 ? 2.73000   4.57600   7.12200   1.000 21.25318  ?  383 LEU   A CA   1 
ATOM   1680 C  C    . LEU   A 1 231 ? 1.91900   5.58600   7.92200   1.000 27.78267  ?  383 LEU   A C    1 
ATOM   1681 O  O    . LEU   A 1 231 ? 2.38900   6.10100   8.94300   1.000 18.58646  ?  383 LEU   A O    1 
ATOM   1682 C  CB   . LEU   A 1 231 ? 3.45300   5.25900   5.96300   1.000 21.53127  ?  383 LEU   A CB   1 
ATOM   1683 C  CG   . LEU   A 1 231 ? 4.49000   4.39800   5.23700   1.000 25.28944  ?  383 LEU   A CG   1 
ATOM   1684 C  CD1  . LEU   A 1 231 ? 5.05100   5.13400   4.02500   1.000 27.92143  ?  383 LEU   A CD1  1 
ATOM   1685 C  CD2  . LEU   A 1 231 ? 5.60600   3.99200   6.18700   1.000 23.50502  ?  383 LEU   A CD2  1 
ATOM   1686 N  N    . ALA   A 1 232 ? 0.69300   5.87800   7.47600   1.000 21.57193  ?  384 ALA   A N    1 
ATOM   1687 C  CA   . ALA   A 1 232 ? -0.18200  6.75800   8.24300   1.000 21.81209  ?  384 ALA   A CA   1 
ATOM   1688 C  C    . ALA   A 1 232 ? -0.59100  6.11600   9.56300   1.000 22.34408  ?  384 ALA   A C    1 
ATOM   1689 O  O    . ALA   A 1 232 ? -0.62600  6.79100   10.60000  1.000 21.60074  ?  384 ALA   A O    1 
ATOM   1690 C  CB   . ALA   A 1 232 ? -1.41500  7.12500   7.41800   1.000 29.32731  ?  384 ALA   A CB   1 
ATOM   1691 N  N    . ASP   A 1 233 ? -0.90800  4.81400   9.54200   1.000 15.58029  ?  385 ASP   A N    1 
ATOM   1692 C  CA   . ASP   A 1 233 ? -1.22800  4.10300   10.78000  1.000 16.30288  ?  385 ASP   A CA   1 
ATOM   1693 C  C    . ASP   A 1 233 ? -0.07700  4.17600   11.77600  1.000 19.72071  ?  385 ASP   A C    1 
ATOM   1694 O  O    . ASP   A 1 233 ? -0.30000  4.34900   12.98100  1.000 19.27738  ?  385 ASP   A O    1 
ATOM   1695 C  CB   . ASP   A 1 233 ? -1.56100  2.63700   10.49000  1.000 20.99833  ?  385 ASP   A CB   1 
ATOM   1696 C  CG   . ASP   A 1 233 ? -2.83000  2.46300   9.67500   1.000 27.30738  ?  385 ASP   A CG   1 
ATOM   1697 O  OD1  . ASP   A 1 233 ? -3.04200  1.34800   9.15600   1.000 32.25283  ?  385 ASP   A OD1  1 
ATOM   1698 O  OD2  . ASP   A 1 233 ? -3.61300  3.42700   9.55200   1.000 29.88103  ?  385 ASP   A OD2  1 
ATOM   1699 N  N    . LEU   A 1 234 ? 1.16300   4.03000   11.29100  1.000 19.65914  ?  386 LEU   A N    1 
ATOM   1700 C  CA   . LEU   A 1 234 ? 2.32500   4.05400   12.17800  1.000 18.20033  ?  386 LEU   A CA   1 
ATOM   1701 C  C    . LEU   A 1 234 ? 2.45100   5.38200   12.90900  1.000 13.95386  ?  386 LEU   A C    1 
ATOM   1702 O  O    . LEU   A 1 234 ? 2.91000   5.41700   14.05500  1.000 17.51373  ?  386 LEU   A O    1 
ATOM   1703 C  CB   . LEU   A 1 234 ? 3.60400   3.78200   11.38300  1.000 21.52532  ?  386 LEU   A CB   1 
ATOM   1704 C  CG   . LEU   A 1 234 ? 3.97600   2.33100   11.09200  1.000 16.19209  ?  386 LEU   A CG   1 
ATOM   1705 C  CD1  . LEU   A 1 234 ? 5.08700   2.27700   10.05300  1.000 20.02265  ?  386 LEU   A CD1  1 
ATOM   1706 C  CD2  . LEU   A 1 234 ? 4.39500   1.62100   12.36800  1.000 15.07345  ?  386 LEU   A CD2  1 
ATOM   1707 N  N    . ARG   A 1 235 ? 2.07400   6.48400   12.25700  1.000 15.57993  ?  387 ARG   A N    1 
ATOM   1708 C  CA   . ARG   A 1 235 ? 2.12700   7.78400   12.91800  1.000 20.11624  ?  387 ARG   A CA   1 
ATOM   1709 C  C    . ARG   A 1 235 ? 1.16000   7.84400   14.09400  1.000 24.34330  ?  387 ARG   A C    1 
ATOM   1710 O  O    . ARG   A 1 235 ? 1.49500   8.39700   15.14700  1.000 19.69927  ?  387 ARG   A O    1 
ATOM   1711 C  CB   . ARG   A 1 235 ? 1.83400   8.90000   11.91400  1.000 23.98308  ?  387 ARG   A CB   1 
ATOM   1712 C  CG   . ARG   A 1 235 ? 2.57800   8.75600   10.59900  1.000 34.07406  ?  387 ARG   A CG   1 
ATOM   1713 C  CD   . ARG   A 1 235 ? 4.07600   8.99800   10.76200  1.000 35.76538  ?  387 ARG   A CD   1 
ATOM   1714 N  NE   . ARG   A 1 235 ? 4.36100   10.37300  11.15400  1.000 38.49867  ?  387 ARG   A NE   1 
ATOM   1715 C  CZ   . ARG   A 1 235 ? 4.91500   11.28100  10.35600  1.000 31.00410  ?  387 ARG   A CZ   1 
ATOM   1716 N  NH1  . ARG   A 1 235 ? 5.12900   12.50900  10.80600  1.000 36.50763  ?  387 ARG   A NH1  1 
ATOM   1717 N  NH2  . ARG   A 1 235 ? 5.26000   10.96300  9.11600   1.000 37.05570  ?  387 ARG   A NH2  1 
ATOM   1718 N  N    A SER   A 1 236 ? -0.04400  7.28500   13.93200  0.470 22.84411  ?  388 SER   A N    1 
ATOM   1719 N  N    B SER   A 1 236 ? -0.04100  7.28000   13.93500  0.530 22.84885  ?  388 SER   A N    1 
ATOM   1720 C  CA   A SER   A 1 236 ? -0.99200  7.23900   15.04100  0.470 22.09272  ?  388 SER   A CA   1 
ATOM   1721 C  CA   B SER   A 1 236 ? -0.99000  7.24500   15.04500  0.530 22.08730  ?  388 SER   A CA   1 
ATOM   1722 C  C    A SER   A 1 236 ? -0.47200  6.36300   16.17200  0.470 18.40594  ?  388 SER   A C    1 
ATOM   1723 C  C    B SER   A 1 236 ? -0.48400  6.35600   16.17400  0.530 18.37296  ?  388 SER   A C    1 
ATOM   1724 O  O    A SER   A 1 236 ? -0.57900  6.72600   17.35000  0.470 18.85783  ?  388 SER   A O    1 
ATOM   1725 O  O    B SER   A 1 236 ? -0.61400  6.70600   17.35300  0.530 18.85357  ?  388 SER   A O    1 
ATOM   1726 C  CB   A SER   A 1 236 ? -2.35300  6.73300   14.55800  0.470 23.52107  ?  388 SER   A CB   1 
ATOM   1727 C  CB   B SER   A 1 236 ? -2.35800  6.76600   14.55800  0.530 23.53345  ?  388 SER   A CB   1 
ATOM   1728 O  OG   A SER   A 1 236 ? -2.86100  7.54100   13.51200  0.470 20.12923  ?  388 SER   A OG   1 
ATOM   1729 O  OG   B SER   A 1 236 ? -3.02100  6.02100   15.56300  0.530 23.59647  ?  388 SER   A OG   1 
ATOM   1730 N  N    . LEU   A 1 237 ? 0.09900   5.20400   15.83300  1.000 16.97423  ?  389 LEU   A N    1 
ATOM   1731 C  CA   . LEU   A 1 237 ? 0.68400   4.34400   16.85700  1.000 17.01334  ?  389 LEU   A CA   1 
ATOM   1732 C  C    . LEU   A 1 237 ? 1.83900   5.04100   17.56500  1.000 17.75348  ?  389 LEU   A C    1 
ATOM   1733 O  O    . LEU   A 1 237 ? 2.01200   4.89100   18.78000  1.000 19.80722  ?  389 LEU   A O    1 
ATOM   1734 C  CB   . LEU   A 1 237 ? 1.15800   3.03500   16.23000  1.000 17.07689  ?  389 LEU   A CB   1 
ATOM   1735 C  CG   . LEU   A 1 237 ? 0.05000   2.10700   15.73400  1.000 24.45699  ?  389 LEU   A CG   1 
ATOM   1736 C  CD1  . LEU   A 1 237 ? 0.61200   1.10100   14.74000  1.000 18.74943  ?  389 LEU   A CD1  1 
ATOM   1737 C  CD2  . LEU   A 1 237 ? -0.60800  1.40200   16.91500  1.000 19.91315  ?  389 LEU   A CD2  1 
ATOM   1738 N  N    . ASN   A 1 238 ? 2.64800   5.79200   16.81100  1.000 16.39096  ?  390 ASN   A N    1 
ATOM   1739 C  CA   . ASN   A 1 238 ? 3.72000   6.59600   17.39900  1.000 18.28278  ?  390 ASN   A CA   1 
ATOM   1740 C  C    . ASN   A 1 238 ? 3.17500   7.54500   18.46100  1.000 25.46692  ?  390 ASN   A C    1 
ATOM   1741 O  O    . ASN   A 1 238 ? 3.67300   7.58700   19.59400  1.000 18.41024  ?  390 ASN   A O    1 
ATOM   1742 C  CB   . ASN   A 1 238 ? 4.43400   7.38200   16.29100  1.000 14.93978  ?  390 ASN   A CB   1 
ATOM   1743 C  CG   . ASN   A 1 238 ? 5.79000   7.92200   16.71500  1.000 24.38454  ?  390 ASN   A CG   1 
ATOM   1744 O  OD1  . ASN   A 1 238 ? 6.63700   8.23100   15.87000  1.000 19.75779  ?  390 ASN   A OD1  1 
ATOM   1745 N  ND2  . ASN   A 1 238 ? 6.00400   8.04800   18.01600  1.000 16.63504  ?  390 ASN   A ND2  1 
ATOM   1746 N  N    . GLU   A 1 239 ? 2.15500   8.32600   18.10000  1.000 19.12770  ?  391 GLU   A N    1 
ATOM   1747 C  CA   . GLU   A 1 239 ? 1.57600   9.29100   19.03100  1.000 27.97598  ?  391 GLU   A CA   1 
ATOM   1748 C  C    . GLU   A 1 239 ? 1.08000   8.60800   20.30100  1.000 21.47493  ?  391 GLU   A C    1 
ATOM   1749 O  O    . GLU   A 1 239 ? 1.36300   9.06300   21.41600  1.000 18.09419  ?  391 GLU   A O    1 
ATOM   1750 C  CB   . GLU   A 1 239 ? 0.43800   10.05300  18.34600  1.000 27.45571  ?  391 GLU   A CB   1 
ATOM   1751 C  CG   . GLU   A 1 239 ? 0.87500   10.85400  17.13000  1.000 34.33816  ?  391 GLU   A CG   1 
ATOM   1752 C  CD   . GLU   A 1 239 ? -0.29500  11.30600  16.26900  1.000 56.79998  ?  391 GLU   A CD   1 
ATOM   1753 O  OE1  . GLU   A 1 239 ? -1.43500  10.86100  16.52100  1.000 54.54604  ?  391 GLU   A OE1  1 
ATOM   1754 O  OE2  . GLU   A 1 239 ? -0.07200  12.10300  15.33300  1.000 50.50904  ?  391 GLU   A OE2  1 
ATOM   1755 N  N    . GLU   A 1 240 ? 0.34200   7.50500   20.15100  1.000 19.04871  ?  392 GLU   A N    1 
ATOM   1756 C  CA   . GLU   A 1 240 ? -0.18500  6.81300   21.32400  1.000 22.79399  ?  392 GLU   A CA   1 
ATOM   1757 C  C    . GLU   A 1 240 ? 0.93300   6.21600   22.17100  1.000 24.62356  ?  392 GLU   A C    1 
ATOM   1758 O  O    . GLU   A 1 240 ? 0.88100   6.27900   23.40500  1.000 20.67554  ?  392 GLU   A O    1 
ATOM   1759 C  CB   . GLU   A 1 240 ? -1.17300  5.72600   20.89900  1.000 20.78835  ?  392 GLU   A CB   1 
ATOM   1760 C  CG   . GLU   A 1 240 ? -1.84800  4.99900   22.06000  1.000 17.73481  ?  392 GLU   A CG   1 
ATOM   1761 C  CD   . GLU   A 1 240 ? -2.60900  5.93500   22.99000  1.000 28.45326  ?  392 GLU   A CD   1 
ATOM   1762 O  OE1  . GLU   A 1 240 ? -2.67700  5.64300   24.20300  1.000 26.16293  ?  392 GLU   A OE1  1 
ATOM   1763 O  OE2  . GLU   A 1 240 ? -3.14500  6.95800   22.51100  1.000 28.48824  ?  392 GLU   A OE2  1 
ATOM   1764 N  N    . HIS   A 1 241 ? 1.94600   5.62200   21.53400  1.000 17.06428  ?  393 HIS   A N    1 
ATOM   1765 C  CA   . HIS   A 1 241 ? 3.06800   5.09800   22.30600  1.000 16.74962  ?  393 HIS   A CA   1 
ATOM   1766 C  C    . HIS   A 1 241 ? 3.79700   6.21000   23.04700  1.000 16.08989  ?  393 HIS   A C    1 
ATOM   1767 O  O    . HIS   A 1 241 ? 4.21100   6.02700   24.19800  1.000 20.06648  ?  393 HIS   A O    1 
ATOM   1768 C  CB   . HIS   A 1 241 ? 4.05300   4.34400   21.41400  1.000 18.74312  ?  393 HIS   A CB   1 
ATOM   1769 C  CG   . HIS   A 1 241 ? 5.27900   3.89800   22.14700  1.000 20.31037  ?  393 HIS   A CG   1 
ATOM   1770 N  ND1  . HIS   A 1 241 ? 6.41500   4.67300   22.24000  1.000 18.25168  ?  393 HIS   A ND1  1 
ATOM   1771 C  CD2  . HIS   A 1 241 ? 5.52900   2.77800   22.86600  1.000 15.68478  ?  393 HIS   A CD2  1 
ATOM   1772 C  CE1  . HIS   A 1 241 ? 7.31900   4.04100   22.96600  1.000 20.03374  ?  393 HIS   A CE1  1 
ATOM   1773 N  NE2  . HIS   A 1 241 ? 6.80700   2.88800   23.35700  1.000 17.55262  ?  393 HIS   A NE2  1 
ATOM   1774 N  N    A SER   A 1 242 ? 3.96900   7.36700   22.40200  0.450 20.69765  ?  394 SER   A N    1 
ATOM   1775 N  N    B SER   A 1 242 ? 3.97200   7.36500   22.40200  0.550 20.69741  ?  394 SER   A N    1 
ATOM   1776 C  CA   A SER   A 1 242 ? 4.62200   8.49800   23.05700  0.450 22.98780  ?  394 SER   A CA   1 
ATOM   1777 C  CA   B SER   A 1 242 ? 4.62600   8.49100   23.06400  0.550 22.99686  ?  394 SER   A CA   1 
ATOM   1778 C  C    A SER   A 1 242 ? 3.84800   8.93400   24.29500  0.450 20.50626  ?  394 SER   A C    1 
ATOM   1779 C  C    B SER   A 1 242 ? 3.84800   8.92600   24.29900  0.550 20.47733  ?  394 SER   A C    1 
ATOM   1780 O  O    A SER   A 1 242 ? 4.43600   9.19000   25.35200  0.450 19.39267  ?  394 SER   A O    1 
ATOM   1781 O  O    B SER   A 1 242 ? 4.43200   9.17100   25.36000  0.550 19.33947  ?  394 SER   A O    1 
ATOM   1782 C  CB   A SER   A 1 242 ? 4.76200   9.66200   22.07500  0.450 21.36545  ?  394 SER   A CB   1 
ATOM   1783 C  CB   B SER   A 1 242 ? 4.78200   9.65500   22.08700  0.550 21.35058  ?  394 SER   A CB   1 
ATOM   1784 O  OG   A SER   A 1 242 ? 5.57400   9.30600   20.97200  0.450 27.12900  ?  394 SER   A OG   1 
ATOM   1785 O  OG   B SER   A 1 242 ? 5.22900   10.82100  22.75900  0.550 30.06615  ?  394 SER   A OG   1 
ATOM   1786 N  N    . LYS   A 1 243 ? 2.52200   9.02400   24.17900  1.000 19.75700  ?  395 LYS   A N    1 
ATOM   1787 C  CA   . LYS   A 1 243 ? 1.69300   9.38600   25.32400  1.000 22.63440  ?  395 LYS   A CA   1 
ATOM   1788 C  C    . LYS   A 1 243 ? 1.89300   8.41100   26.47700  1.000 22.86258  ?  395 LYS   A C    1 
ATOM   1789 O  O    . LYS   A 1 243 ? 2.11700   8.81900   27.62100  1.000 26.23505  ?  395 LYS   A O    1 
ATOM   1790 C  CB   . LYS   A 1 243 ? 0.22400   9.42900   24.89600  1.000 20.21291  ?  395 LYS   A CB   1 
ATOM   1791 C  CG   . LYS   A 1 243 ? -0.77300  9.65400   26.01600  1.000 47.00724  ?  395 LYS   A CG   1 
ATOM   1792 C  CD   . LYS   A 1 243 ? -2.17800  9.83500   25.44600  1.000 53.80540  ?  395 LYS   A CD   1 
ATOM   1793 C  CE   . LYS   A 1 243 ? -2.83600  11.10800  25.95100  1.000 59.48956  ?  395 LYS   A CE   1 
ATOM   1794 N  NZ   . LYS   A 1 243 ? -4.22500  11.26200  25.43200  1.000 63.46141  ?  395 LYS   A NZ   1 
ATOM   1795 N  N    . GLN   A 1 244 ? 1.84000   7.11200   26.18800  1.000 19.57372  ?  396 GLN   A N    1 
ATOM   1796 C  CA   . GLN   A 1 244 ? 1.96000   6.11600   27.24500  1.000 16.61413  ?  396 GLN   A CA   1 
ATOM   1797 C  C    . GLN   A 1 244 ? 3.39100   6.02200   27.76600  1.000 20.57069  ?  396 GLN   A C    1 
ATOM   1798 O  O    . GLN   A 1 244 ? 3.60300   5.79600   28.96400  1.000 20.35343  ?  396 GLN   A O    1 
ATOM   1799 C  CB   . GLN   A 1 244 ? 1.46400   4.75800   26.74000  1.000 18.04552  ?  396 GLN   A CB   1 
ATOM   1800 C  CG   . GLN   A 1 244 ? -0.00600  4.77600   26.31600  1.000 18.37123  ?  396 GLN   A CG   1 
ATOM   1801 C  CD   . GLN   A 1 244 ? -0.61700  3.38900   26.18800  1.000 22.79762  ?  396 GLN   A CD   1 
ATOM   1802 O  OE1  . GLN   A 1 244 ? -0.07600  2.40800   26.69400  1.000 22.39163  ?  396 GLN   A OE1  1 
ATOM   1803 N  NE2  . GLN   A 1 244 ? -1.76200  3.30800   25.51200  1.000 23.38522  ?  396 GLN   A NE2  1 
ATOM   1804 N  N    . TYR   A 1 245 ? 4.38800   6.19400   26.89000  1.000 18.68987  ?  397 TYR   A N    1 
ATOM   1805 C  CA   . TYR   A 1 245 ? 5.76800   6.18600   27.36300  1.000 20.04086  ?  397 TYR   A CA   1 
ATOM   1806 C  C    . TYR   A 1 245 ? 6.03300   7.35400   28.30600  1.000 19.52030  ?  397 TYR   A C    1 
ATOM   1807 O  O    . TYR   A 1 245 ? 6.69000   7.18600   29.33900  1.000 21.88012  ?  397 TYR   A O    1 
ATOM   1808 C  CB   . TYR   A 1 245 ? 6.74900   6.21800   26.18700  1.000 14.81682  ?  397 TYR   A CB   1 
ATOM   1809 C  CG   . TYR   A 1 245 ? 8.19700   6.28800   26.63900  1.000 23.39744  ?  397 TYR   A CG   1 
ATOM   1810 C  CD1  . TYR   A 1 245 ? 8.89700   5.13600   26.97200  1.000 17.19348  ?  397 TYR   A CD1  1 
ATOM   1811 C  CD2  . TYR   A 1 245 ? 8.85600   7.50800   26.74700  1.000 22.58024  ?  397 TYR   A CD2  1 
ATOM   1812 C  CE1  . TYR   A 1 245 ? 10.21800  5.19400   27.39200  1.000 20.88776  ?  397 TYR   A CE1  1 
ATOM   1813 C  CE2  . TYR   A 1 245 ? 10.17200  7.57600   27.16800  1.000 23.06922  ?  397 TYR   A CE2  1 
ATOM   1814 C  CZ   . TYR   A 1 245 ? 10.84800  6.41700   27.48900  1.000 21.66077  ?  397 TYR   A CZ   1 
ATOM   1815 O  OH   . TYR   A 1 245 ? 12.15600  6.48700   27.90700  1.000 19.85400  ?  397 TYR   A OH   1 
ATOM   1816 N  N    A ARG   A 1 246 ? 5.53800   8.54700   27.96400  0.530 21.59653  ?  398 ARG   A N    1 
ATOM   1817 N  N    B ARG   A 1 246 ? 5.54900   8.55000   27.95200  0.470 21.60775  ?  398 ARG   A N    1 
ATOM   1818 C  CA   A ARG   A 1 246 ? 5.72900   9.69900   28.83900  0.530 27.57603  ?  398 ARG   A CA   1 
ATOM   1819 C  CA   B ARG   A 1 246 ? 5.71100   9.70700   28.82900  0.470 27.57492  ?  398 ARG   A CA   1 
ATOM   1820 C  C    A ARG   A 1 246 ? 5.07200   9.47400   30.19500  0.530 27.52820  ?  398 ARG   A C    1 
ATOM   1821 C  C    B ARG   A 1 246 ? 5.08000   9.45500   30.19100  0.470 27.52517  ?  398 ARG   A C    1 
ATOM   1822 O  O    A ARG   A 1 246 ? 5.63000   9.84800   31.23300  0.530 27.00342  ?  398 ARG   A O    1 
ATOM   1823 O  O    B ARG   A 1 246 ? 5.66100   9.79700   31.22700  0.470 26.94200  ?  398 ARG   A O    1 
ATOM   1824 C  CB   A ARG   A 1 246 ? 5.17800   10.96300  28.17900  0.530 30.85660  ?  398 ARG   A CB   1 
ATOM   1825 C  CB   B ARG   A 1 246 ? 5.09500   10.95300  28.18900  0.470 30.84047  ?  398 ARG   A CB   1 
ATOM   1826 C  CG   A ARG   A 1 246 ? 5.99800   11.45400  26.99600  0.530 32.40737  ?  398 ARG   A CG   1 
ATOM   1827 C  CG   B ARG   A 1 246 ? 5.80500   11.46200  26.94600  0.470 32.69349  ?  398 ARG   A CG   1 
ATOM   1828 C  CD   A ARG   A 1 246 ? 5.42200   12.73500  26.40700  0.530 38.46683  ?  398 ARG   A CD   1 
ATOM   1829 C  CD   B ARG   A 1 246 ? 5.17200   12.76100  26.45800  0.470 38.38683  ?  398 ARG   A CD   1 
ATOM   1830 N  NE   A ARG   A 1 246 ? 5.06800   13.70800  27.43800  0.530 44.38286  ?  398 ARG   A NE   1 
ATOM   1831 N  NE   B ARG   A 1 246 ? 4.90600   12.75100  25.02200  0.470 38.13993  ?  398 ARG   A NE   1 
ATOM   1832 C  CZ   A ARG   A 1 246 ? 5.84600   14.72100  27.80500  0.530 42.28799  ?  398 ARG   A CZ   1 
ATOM   1833 C  CZ   B ARG   A 1 246 ? 3.74200   13.08500  24.47300  0.470 36.03863  ?  398 ARG   A CZ   1 
ATOM   1834 N  NH1  A ARG   A 1 246 ? 7.02600   14.89400  27.22600  0.530 41.64260  ?  398 ARG   A NH1  1 
ATOM   1835 N  NH1  B ARG   A 1 246 ? 2.72800   13.46000  25.24000  0.470 33.38117  ?  398 ARG   A NH1  1 
ATOM   1836 N  NH2  A ARG   A 1 246 ? 5.44600   15.55900  28.75100  0.530 43.85228  ?  398 ARG   A NH2  1 
ATOM   1837 N  NH2  B ARG   A 1 246 ? 3.59100   13.04800  23.15500  0.470 32.73708  ?  398 ARG   A NH2  1 
ATOM   1838 N  N    . SER   A 1 247 ? 3.89100   8.85000   30.20700  1.000 22.40505  ?  399 SER   A N    1 
ATOM   1839 C  CA   . SER   A 1 247 ? 3.22000   8.55500   31.46700  1.000 30.45349  ?  399 SER   A CA   1 
ATOM   1840 C  C    . SER   A 1 247 ? 3.97900   7.50100   32.26400  1.000 33.90844  ?  399 SER   A C    1 
ATOM   1841 O  O    . SER   A 1 247 ? 4.06300   7.58600   33.49500  1.000 24.96324  ?  399 SER   A O    1 
ATOM   1842 C  CB   . SER   A 1 247 ? 1.78700   8.09800   31.19200  1.000 30.12426  ?  399 SER   A CB   1 
ATOM   1843 O  OG   . SER   A 1 247 ? 1.14800   7.65700   32.37400  1.000 50.23038  ?  399 SER   A OG   1 
ATOM   1844 N  N    . LEU   A 1 248 ? 4.54700   6.50700   31.58100  1.000 26.77314  ?  400 LEU   A N    1 
ATOM   1845 C  CA   . LEU   A 1 248 ? 5.27900   5.45600   32.27900  1.000 31.57459  ?  400 LEU   A CA   1 
ATOM   1846 C  C    . LEU   A 1 248 ? 6.62200   5.96400   32.78900  1.000 29.70414  ?  400 LEU   A C    1 
ATOM   1847 O  O    . LEU   A 1 248 ? 6.93100   5.83900   33.98100  1.000 23.43123  ?  400 LEU   A O    1 
ATOM   1848 C  CB   . LEU   A 1 248 ? 5.47700   4.25100   31.35500  1.000 29.74717  ?  400 LEU   A CB   1 
ATOM   1849 C  CG   . LEU   A 1 248 ? 4.25100   3.37200   31.11000  1.000 47.69108  ?  400 LEU   A CG   1 
ATOM   1850 C  CD1  . LEU   A 1 248 ? 4.41800   2.55400   29.83300  1.000 29.59993  ?  400 LEU   A CD1  1 
ATOM   1851 C  CD2  . LEU   A 1 248 ? 4.00300   2.46800   32.30900  1.000 35.32452  ?  400 LEU   A CD2  1 
ATOM   1852 N  N    . SER   A 1 249 ? 7.43300   6.54500   31.90100  1.000 28.09512  ?  401 SER   A N    1 
ATOM   1853 C  CA   . SER   A 1 249 ? 8.78100   6.96000   32.26900  1.000 29.10591  ?  401 SER   A CA   1 
ATOM   1854 C  C    . SER   A 1 249 ? 8.79400   8.13300   33.24000  1.000 32.67955  ?  401 SER   A C    1 
ATOM   1855 O  O    . SER   A 1 249 ? 9.84500   8.41700   33.82100  1.000 27.96942  ?  401 SER   A O    1 
ATOM   1856 C  CB   . SER   A 1 249 ? 9.58800   7.31400   31.01800  1.000 19.86367  ?  401 SER   A CB   1 
ATOM   1857 O  OG   . SER   A 1 249 ? 9.01500   8.41000   30.32500  1.000 22.47313  ?  401 SER   A OG   1 
ATOM   1858 N  N    . PHE   A 1 250 ? 7.66000   8.81600   33.42400  1.000 30.84260  ?  402 PHE   A N    1 
ATOM   1859 C  CA   . PHE   A 1 250 ? 7.58200   9.89500   34.40400  1.000 39.87100  ?  402 PHE   A CA   1 
ATOM   1860 C  C    . PHE   A 1 250 ? 7.79200   9.38000   35.82200  1.000 36.10840  ?  402 PHE   A C    1 
ATOM   1861 O  O    . PHE   A 1 250 ? 8.33200   10.09900  36.67000  1.000 37.19855  ?  402 PHE   A O    1 
ATOM   1862 C  CB   . PHE   A 1 250 ? 6.22900   10.59900  34.28500  1.000 35.43046  ?  402 PHE   A CB   1 
ATOM   1863 C  CG   . PHE   A 1 250 ? 6.05900   11.77100  35.20800  1.000 40.85659  ?  402 PHE   A CG   1 
ATOM   1864 C  CD1  . PHE   A 1 250 ? 6.73500   12.95800  34.97800  1.000 48.79724  ?  402 PHE   A CD1  1 
ATOM   1865 C  CD2  . PHE   A 1 250 ? 5.20100   11.69100  36.29600  1.000 44.06118  ?  402 PHE   A CD2  1 
ATOM   1866 C  CE1  . PHE   A 1 250 ? 6.56900   14.04200  35.82300  1.000 51.70630  ?  402 PHE   A CE1  1 
ATOM   1867 C  CE2  . PHE   A 1 250 ? 5.03100   12.77100  37.14400  1.000 53.64784  ?  402 PHE   A CE2  1 
ATOM   1868 C  CZ   . PHE   A 1 250 ? 5.71600   13.94800  36.90700  1.000 39.82883  ?  402 PHE   A CZ   1 
ATOM   1869 N  N    . GLN   A 1 251 ? 7.37700   8.14700   36.09600  1.000 32.16963  ?  403 GLN   A N    1 
ATOM   1870 C  CA   . GLN   A 1 251 ? 7.57200   7.55000   37.41000  1.000 25.14140  ?  403 GLN   A CA   1 
ATOM   1871 C  C    . GLN   A 1 251 ? 8.98800   6.99500   37.52100  1.000 31.18778  ?  403 GLN   A C    1 
ATOM   1872 O  O    . GLN   A 1 251 ? 9.35800   6.11100   36.73900  1.000 26.10337  ?  403 GLN   A O    1 
ATOM   1873 C  CB   . GLN   A 1 251 ? 6.55200   6.44500   37.64200  1.000 26.83149  ?  403 GLN   A CB   1 
ATOM   1874 C  CG   . GLN   A 1 251 ? 5.10000   6.91100   37.60000  1.000 40.36604  ?  403 GLN   A CG   1 
ATOM   1875 C  CD   . GLN   A 1 251 ? 4.80300   8.00600   38.60800  1.000 49.40163  ?  403 GLN   A CD   1 
ATOM   1876 O  OE1  . GLN   A 1 251 ? 4.14300   8.99600   38.28900  1.000 54.36804  ?  403 GLN   A OE1  1 
ATOM   1877 N  NE2  . GLN   A 1 251 ? 5.28500   7.83100   39.83300  1.000 50.19841  ?  403 GLN   A NE2  1 
ATOM   1878 N  N    . PRO   A 1 252 ? 9.80300   7.47400   38.46600  1.000 30.17229  ?  404 PRO   A N    1 
ATOM   1879 C  CA   . PRO   A 1 252 ? 11.21200  7.04600   38.50900  1.000 21.82923  ?  404 PRO   A CA   1 
ATOM   1880 C  C    . PRO   A 1 252 ? 11.41500  5.55400   38.73300  1.000 25.21997  ?  404 PRO   A C    1 
ATOM   1881 O  O    . PRO   A 1 252 ? 12.43400  5.01200   38.28700  1.000 26.07473  ?  404 PRO   A O    1 
ATOM   1882 C  CB   . PRO   A 1 252 ? 11.78500  7.87200   39.66800  1.000 25.65312  ?  404 PRO   A CB   1 
ATOM   1883 C  CG   . PRO   A 1 252 ? 10.92500  9.09300   39.70500  1.000 32.45974  ?  404 PRO   A CG   1 
ATOM   1884 C  CD   . PRO   A 1 252 ? 9.54100   8.60300   39.37400  1.000 25.75656  ?  404 PRO   A CD   1 
ATOM   1885 N  N    . GLU   A 1 253 ? 10.49900  4.86900   39.41800  1.000 22.48189  ?  405 GLU   A N    1 
ATOM   1886 C  CA   . GLU   A 1 253 ? 10.64400  3.42200   39.54100  1.000 28.38752  ?  405 GLU   A CA   1 
ATOM   1887 C  C    . GLU   A 1 253 ? 10.43700  2.71700   38.20700  1.000 26.58584  ?  405 GLU   A C    1 
ATOM   1888 O  O    . GLU   A 1 253 ? 10.92900  1.59800   38.03100  1.000 27.08219  ?  405 GLU   A O    1 
ATOM   1889 C  CB   . GLU   A 1 253 ? 9.68100   2.85200   40.59100  1.000 33.95538  ?  405 GLU   A CB   1 
ATOM   1890 C  CG   . GLU   A 1 253 ? 8.21600   3.25900   40.45900  1.000 43.80339  ?  405 GLU   A CG   1 
ATOM   1891 C  CD   . GLU   A 1 253 ? 7.96300   4.69900   40.85800  1.000 29.43694  ?  405 GLU   A CD   1 
ATOM   1892 O  OE1  . GLU   A 1 253 ? 8.80900   5.27300   41.56800  1.000 50.18851  ?  405 GLU   A OE1  1 
ATOM   1893 O  OE2  . GLU   A 1 253 ? 6.91400   5.25400   40.47700  1.000 55.28877  ?  405 GLU   A OE2  1 
ATOM   1894 N  N    . ASN   A 1 254 ? 9.73000   3.34900   37.26500  1.000 22.47937  ?  406 ASN   A N    1 
ATOM   1895 C  CA   . ASN   A 1 254 ? 9.59600   2.78300   35.92600  1.000 21.89240  ?  406 ASN   A CA   1 
ATOM   1896 C  C    . ASN   A 1 254 ? 10.82500  3.08800   35.07800  1.000 22.73777  ?  406 ASN   A C    1 
ATOM   1897 O  O    . ASN   A 1 254 ? 11.35300  2.20200   34.39500  1.000 22.17604  ?  406 ASN   A O    1 
ATOM   1898 C  CB   . ASN   A 1 254 ? 8.34000   3.32000   35.23500  1.000 19.96955  ?  406 ASN   A CB   1 
ATOM   1899 C  CG   . ASN   A 1 254 ? 7.06200   2.89200   35.92100  1.000 31.71497  ?  406 ASN   A CG   1 
ATOM   1900 O  OD1  . ASN   A 1 254 ? 5.97500   3.34700   35.56600  1.000 28.20652  ?  406 ASN   A OD1  1 
ATOM   1901 N  ND2  . ASN   A 1 254 ? 7.18400   2.02300   36.91500  1.000 26.43029  ?  406 ASN   A ND2  1 
ATOM   1902 N  N    A SER   A 1 255 ? 11.29200  4.33900   35.10300  0.440 23.41232  ?  407 SER   A N    1 
ATOM   1903 N  N    B SER   A 1 255 ? 11.27900  4.34600   35.09900  0.560 23.40330  ?  407 SER   A N    1 
ATOM   1904 C  CA   A SER   A 1 255 ? 12.48000  4.69200   34.33200  0.440 22.06932  ?  407 SER   A CA   1 
ATOM   1905 C  CA   B SER   A 1 255 ? 12.47900  4.72000   34.35700  0.560 22.06271  ?  407 SER   A CA   1 
ATOM   1906 C  C    A SER   A 1 255 ? 13.70300  3.92700   34.81700  0.440 23.12131  ?  407 SER   A C    1 
ATOM   1907 C  C    B SER   A 1 255 ? 13.68800  3.91900   34.81600  0.560 23.12859  ?  407 SER   A C    1 
ATOM   1908 O  O    A SER   A 1 255 ? 14.63300  3.68800   34.03700  0.440 22.49612  ?  407 SER   A O    1 
ATOM   1909 O  O    B SER   A 1 255 ? 14.59200  3.64700   34.01600  0.560 22.50553  ?  407 SER   A O    1 
ATOM   1910 C  CB   A SER   A 1 255 ? 12.72900  6.19900   34.40400  0.440 23.65245  ?  407 SER   A CB   1 
ATOM   1911 C  CB   B SER   A 1 255 ? 12.74900  6.21700   34.51400  0.560 23.73303  ?  407 SER   A CB   1 
ATOM   1912 O  OG   A SER   A 1 255 ? 12.86800  6.62800   35.74600  0.440 29.20594  ?  407 SER   A OG   1 
ATOM   1913 O  OG   B SER   A 1 255 ? 11.89500  6.98700   33.69000  0.560 23.47648  ?  407 SER   A OG   1 
ATOM   1914 N  N    . MET   A 1 256 ? 13.71700  3.53200   36.09500  1.000 21.31701  ?  408 MET   A N    1 
ATOM   1915 C  CA   . MET   A 1 256 ? 14.79800  2.69500   36.61100  1.000 26.90999  ?  408 MET   A CA   1 
ATOM   1916 C  C    . MET   A 1 256 ? 14.91500  1.38600   35.84600  1.000 20.69382  ?  408 MET   A C    1 
ATOM   1917 O  O    . MET   A 1 256 ? 16.00100  0.80100   35.77800  1.000 20.16696  ?  408 MET   A O    1 
ATOM   1918 C  CB   . MET   A 1 256 ? 14.55800  2.38400   38.08900  1.000 25.15480  ?  408 MET   A CB   1 
ATOM   1919 C  CG   . MET   A 1 256 ? 15.21800  3.31500   39.08000  1.000 33.03632  ?  408 MET   A CG   1 
ATOM   1920 S  SD   . MET   A 1 256 ? 15.10700  2.65000   40.75700  1.000 34.88435  ?  408 MET   A SD   1 
ATOM   1921 C  CE   . MET   A 1 256 ? 13.63600  1.63100   40.64400  1.000 32.45651  ?  408 MET   A CE   1 
ATOM   1922 N  N    . LYS   A 1 257 ? 13.81300  0.90600   35.27900  1.000 20.01684  ?  409 LYS   A N    1 
ATOM   1923 C  CA   . LYS   A 1 257 ? 13.77000  -0.38800  34.61900  1.000 13.47070  ?  409 LYS   A CA   1 
ATOM   1924 C  C    . LYS   A 1 257 ? 14.16400  -0.31800  33.15400  1.000 19.32646  ?  409 LYS   A C    1 
ATOM   1925 O  O    . LYS   A 1 257 ? 14.27600  -1.36500  32.50600  1.000 20.59039  ?  409 LYS   A O    1 
ATOM   1926 C  CB   . LYS   A 1 257 ? 12.36300  -0.97300  34.72600  1.000 18.17362  ?  409 LYS   A CB   1 
ATOM   1927 C  CG   . LYS   A 1 257 ? 12.02600  -1.40200  36.13800  1.000 29.49456  ?  409 LYS   A CG   1 
ATOM   1928 C  CD   . LYS   A 1 257 ? 10.58400  -1.86200  36.25500  1.000 34.00183  ?  409 LYS   A CD   1 
ATOM   1929 C  CE   . LYS   A 1 257 ? 10.15900  -2.01800  37.71700  1.000 49.74855  ?  409 LYS   A CE   1 
ATOM   1930 N  NZ   . LYS   A 1 257 ? 8.96900   -1.17800  38.05800  1.000 50.34846  ?  409 LYS   A NZ   1 
ATOM   1931 N  N    . LEU   A 1 258 ? 14.33300  0.88000   32.60900  1.000 16.43949  ?  410 LEU   A N    1 
ATOM   1932 C  CA   . LEU   A 1 258 ? 14.64700  1.04400   31.20000  1.000 15.89446  ?  410 LEU   A CA   1 
ATOM   1933 C  C    . LEU   A 1 258 ? 16.15800  0.92300   31.01000  1.000 20.78681  ?  410 LEU   A C    1 
ATOM   1934 O  O    . LEU   A 1 258 ? 16.89100  0.54900   31.92900  1.000 19.48102  ?  410 LEU   A O    1 
ATOM   1935 C  CB   . LEU   A 1 258 ? 14.09600  2.37500   30.69100  1.000 15.50825  ?  410 LEU   A CB   1 
ATOM   1936 C  CG   . LEU   A 1 258 ? 12.59300  2.58000   30.90300  1.000 18.64832  ?  410 LEU   A CG   1 
ATOM   1937 C  CD1  . LEU   A 1 258 ? 12.14700  3.94500   30.41400  1.000 15.57531  ?  410 LEU   A CD1  1 
ATOM   1938 C  CD2  . LEU   A 1 258 ? 11.80000  1.47600   30.20800  1.000 18.31958  ?  410 LEU   A CD2  1 
ATOM   1939 N  N    . THR   A 1 259 ? 16.63700  1.22400   29.81000  1.000 16.43995  ?  411 THR   A N    1 
ATOM   1940 C  CA   . THR   A 1 259 ? 18.06000  1.24400   29.51500  1.000 17.49783  ?  411 THR   A CA   1 
ATOM   1941 C  C    . THR   A 1 259 ? 18.51900  2.67000   29.24300  1.000 16.69881  ?  411 THR   A C    1 
ATOM   1942 O  O    . THR   A 1 259 ? 17.70500  3.54700   28.93200  1.000 17.42423  ?  411 THR   A O    1 
ATOM   1943 C  CB   . THR   A 1 259 ? 18.39000  0.37000   28.29700  1.000 19.46014  ?  411 THR   A CB   1 
ATOM   1944 O  OG1  . THR   A 1 259 ? 17.96000  1.04000   27.10700  1.000 16.63439  ?  411 THR   A OG1  1 
ATOM   1945 C  CG2  . THR   A 1 259 ? 17.70800  -0.99400  28.39800  1.000 16.59430  ?  411 THR   A CG2  1 
ATOM   1946 N  N    . PRO   A 1 260 ? 19.82300  2.94300   29.36000  1.000 16.74286  ?  412 PRO   A N    1 
ATOM   1947 C  CA   . PRO   A 1 260 ? 20.30800  4.29300   29.02600  1.000 17.54359  ?  412 PRO   A CA   1 
ATOM   1948 C  C    . PRO   A 1 260 ? 19.99300  4.71100   27.60000  1.000 17.38543  ?  412 PRO   A C    1 
ATOM   1949 O  O    . PRO   A 1 260 ? 19.63000  5.87200   27.36800  1.000 15.98446  ?  412 PRO   A O    1 
ATOM   1950 C  CB   . PRO   A 1 260 ? 21.82100  4.18700   29.26900  1.000 18.38717  ?  412 PRO   A CB   1 
ATOM   1951 C  CG   . PRO   A 1 260 ? 21.97100  3.07500   30.25600  1.000 19.62221  ?  412 PRO   A CG   1 
ATOM   1952 C  CD   . PRO   A 1 260 ? 20.88900  2.09100   29.92000  1.000 21.78077  ?  412 PRO   A CD   1 
ATOM   1953 N  N    . LEU   A 1 261 ? 20.11900  3.79600   26.63300  1.000 15.76839  ?  413 LEU   A N    1 
ATOM   1954 C  CA   . LEU   A 1 261 ? 19.82900  4.14500   25.24500  1.000 19.48429  ?  413 LEU   A CA   1 
ATOM   1955 C  C    . LEU   A 1 261 ? 18.35500  4.47800   25.05400  1.000 18.20883  ?  413 LEU   A C    1 
ATOM   1956 O  O    . LEU   A 1 261 ? 18.01500  5.41600   24.32200  1.000 16.01268  ?  413 LEU   A O    1 
ATOM   1957 C  CB   . LEU   A 1 261 ? 20.24000  3.00700   24.30900  1.000 19.93418  ?  413 LEU   A CB   1 
ATOM   1958 C  CG   . LEU   A 1 261 ? 20.08900  3.33300   22.81900  1.000 22.07781  ?  413 LEU   A CG   1 
ATOM   1959 C  CD1  . LEU   A 1 261 ? 21.00500  4.49000   22.41300  1.000 17.70796  ?  413 LEU   A CD1  1 
ATOM   1960 C  CD2  . LEU   A 1 261 ? 20.33200  2.10800   21.94600  1.000 18.29497  ?  413 LEU   A CD2  1 
ATOM   1961 N  N    . VAL   A 1 262 ? 17.46600  3.71700   25.69900  1.000 17.18925  ?  414 VAL   A N    1 
ATOM   1962 C  CA   . VAL   A 1 262 ? 16.03700  3.99500   25.59200  1.000 14.65982  ?  414 VAL   A CA   1 
ATOM   1963 C  C    . VAL   A 1 262 ? 15.72100  5.36900   26.16200  1.000 16.23736  ?  414 VAL   A C    1 
ATOM   1964 O  O    . VAL   A 1 262 ? 14.97600  6.15100   25.55700  1.000 15.56075  ?  414 VAL   A O    1 
ATOM   1965 C  CB   . VAL   A 1 262 ? 15.22000  2.88600   26.28100  1.000 15.20141  ?  414 VAL   A CB   1 
ATOM   1966 C  CG1  . VAL   A 1 262 ? 13.77700  3.33500   26.49100  1.000 16.07539  ?  414 VAL   A CG1  1 
ATOM   1967 C  CG2  . VAL   A 1 262 ? 15.26900  1.60900   25.45400  1.000 16.72556  ?  414 VAL   A CG2  1 
ATOM   1968 N  N    . LEU   A 1 263 ? 16.29700  5.69500   27.32300  1.000 16.05261  ?  415 LEU   A N    1 
ATOM   1969 C  CA   . LEU   A 1 263 ? 16.05800  7.00700   27.91900  1.000 15.50278  ?  415 LEU   A CA   1 
ATOM   1970 C  C    . LEU   A 1 263 ? 16.56400  8.12600   27.01600  1.000 15.96148  ?  415 LEU   A C    1 
ATOM   1971 O  O    . LEU   A 1 263 ? 15.91000  9.16600   26.87800  1.000 18.11726  ?  415 LEU   A O    1 
ATOM   1972 C  CB   . LEU   A 1 263 ? 16.72100  7.09000   29.29500  1.000 17.50161  ?  415 LEU   A CB   1 
ATOM   1973 C  CG   . LEU   A 1 263 ? 16.08400  6.28000   30.42500  1.000 22.34138  ?  415 LEU   A CG   1 
ATOM   1974 C  CD1  . LEU   A 1 263 ? 16.91500  6.39800   31.69400  1.000 23.40438  ?  415 LEU   A CD1  1 
ATOM   1975 C  CD2  . LEU   A 1 263 ? 14.65300  6.74300   30.67600  1.000 19.87659  ?  415 LEU   A CD2  1 
ATOM   1976 N  N    . GLU   A 1 264 ? 17.72100  7.92700   26.38500  1.000 20.08305  ?  416 GLU   A N    1 
ATOM   1977 C  CA   . GLU   A 1 264 ? 18.28800  8.97300   25.54100  1.000 18.11206  ?  416 GLU   A CA   1 
ATOM   1978 C  C    . GLU   A 1 264 ? 17.46000  9.16900   24.27700  1.000 24.31807  ?  416 GLU   A C    1 
ATOM   1979 O  O    . GLU   A 1 264 ? 17.11900  10.30100  23.91500  1.000 21.33339  ?  416 GLU   A O    1 
ATOM   1980 C  CB   . GLU   A 1 264 ? 19.73400  8.63200   25.18300  1.000 14.36797  ?  416 GLU   A CB   1 
ATOM   1981 C  CG   . GLU   A 1 264 ? 20.46300  9.76500   24.47000  1.000 23.81071  ?  416 GLU   A CG   1 
ATOM   1982 C  CD   . GLU   A 1 264 ? 21.82900  9.35300   23.98000  1.000 22.32831  ?  416 GLU   A CD   1 
ATOM   1983 O  OE1  . GLU   A 1 264 ? 21.95000  8.98500   22.79100  1.000 22.78584  ?  416 GLU   A OE1  1 
ATOM   1984 O  OE2  . GLU   A 1 264 ? 22.78000  9.39400   24.78600  1.000 25.57906  ?  416 GLU   A OE2  1 
ATOM   1985 N  N    . VAL   A 1 265 ? 17.12000  8.07300   23.60000  1.000 17.49443  ?  417 VAL   A N    1 
ATOM   1986 C  CA   . VAL   A 1 265 ? 16.47800  8.17200   22.29300  1.000 16.97738  ?  417 VAL   A CA   1 
ATOM   1987 C  C    . VAL   A 1 265 ? 15.02100  8.59800   22.43400  1.000 25.95351  ?  417 VAL   A C    1 
ATOM   1988 O  O    . VAL   A 1 265 ? 14.53000  9.43200   21.66400  1.000 20.91049  ?  417 VAL   A O    1 
ATOM   1989 C  CB   . VAL   A 1 265 ? 16.61600  6.83700   21.53900  1.000 19.52966  ?  417 VAL   A CB   1 
ATOM   1990 C  CG1  . VAL   A 1 265 ? 15.75600  6.84000   20.28000  1.000 21.35828  ?  417 VAL   A CG1  1 
ATOM   1991 C  CG2  . VAL   A 1 265 ? 18.07800  6.57900   21.19300  1.000 15.50880  ?  417 VAL   A CG2  1 
ATOM   1992 N  N    . PHE   A 1 266 ? 14.30800  8.04100   23.41400  1.000 17.30911  ?  418 PHE   A N    1 
ATOM   1993 C  CA   . PHE   A 1 266 ? 12.89100  8.33100   23.60800  1.000 20.75397  ?  418 PHE   A CA   1 
ATOM   1994 C  C    . PHE   A 1 266 ? 12.64100  9.56400   24.47200  1.000 28.36369  ?  418 PHE   A C    1 
ATOM   1995 O  O    . PHE   A 1 266 ? 11.47900  9.93200   24.67000  1.000 30.00064  ?  418 PHE   A O    1 
ATOM   1996 C  CB   . PHE   A 1 266 ? 12.18000  7.12400   24.23700  1.000 21.40175  ?  418 PHE   A CB   1 
ATOM   1997 C  CG   . PHE   A 1 266 ? 12.02300  5.94700   23.30800  1.000 17.23452  ?  418 PHE   A CG   1 
ATOM   1998 C  CD1  . PHE   A 1 266 ? 11.53800  4.74000   23.78100  1.000 23.50347  ?  418 PHE   A CD1  1 
ATOM   1999 C  CD2  . PHE   A 1 266 ? 12.35800  6.04500   21.96600  1.000 25.87359  ?  418 PHE   A CD2  1 
ATOM   2000 C  CE1  . PHE   A 1 266 ? 11.38800  3.65300   22.93800  1.000 23.19338  ?  418 PHE   A CE1  1 
ATOM   2001 C  CE2  . PHE   A 1 266 ? 12.21300  4.96000   21.11600  1.000 24.34167  ?  418 PHE   A CE2  1 
ATOM   2002 C  CZ   . PHE   A 1 266 ? 11.72500  3.76400   21.60300  1.000 21.34617  ?  418 PHE   A CZ   1 
ATOM   2003 N  N    . GLY   A 1 267 ? 13.69500  10.22300  24.97100  1.000 27.95057  ?  419 GLY   A N    1 
ATOM   2004 C  CA   . GLY   A 1 267 ? 13.53500  11.23900  25.99100  1.000 39.89539  ?  419 GLY   A CA   1 
ATOM   2005 C  C    . GLY   A 1 267 ? 13.32400  12.65600  25.46400  1.000 50.37412  ?  419 GLY   A C    1 
ATOM   2006 O  O    . GLY   A 1 267 ? 13.61700  12.96300  24.30900  1.000 46.32708  ?  419 GLY   A O    1 
ATOM   2007 N  N    . ASN   A 1 268 ? 12.82400  13.50600  26.35900  1.000 68.93758  ?  420 ASN   A N    1 
ATOM   2008 C  CA   . ASN   A 1 268 ? 12.48100  14.90400  26.07500  1.000 82.37150  ?  420 ASN   A CA   1 
ATOM   2009 C  C    . ASN   A 1 268 ? 11.38900  15.01500  25.02100  1.000 82.56351  ?  420 ASN   A C    1 
ATOM   2010 O  O    . ASN   A 1 268 ? 10.35400  15.64100  25.25600  1.000 92.29398  ?  420 ASN   A O    1 
ATOM   2011 C  CB   . ASN   A 1 268 ? 13.71300  15.70000  25.63100  1.000 83.49038  ?  420 ASN   A CB   1 
ATOM   2012 C  CG   . ASN   A 1 268 ? 13.92300  16.95000  26.45900  1.000 90.28136  ?  420 ASN   A CG   1 
ATOM   2013 O  OD1  . ASN   A 1 268 ? 13.86600  16.91100  27.68800  1.000 98.92133  ?  420 ASN   A OD1  1 
ATOM   2014 N  ND2  . ASN   A 1 268 ? 14.14600  18.07400  25.78800  1.000 88.67220  ?  420 ASN   A ND2  1 
ATOM   2015 N  N    . LYS   B 2 1   ? 20.23500  17.82500  21.03300  1.000 92.91149  ?  625 LYS   C N    1 
ATOM   2016 C  CA   . LYS   B 2 1   ? 21.69000  17.92400  20.93800  1.000 89.69639  ?  625 LYS   C CA   1 
ATOM   2017 C  C    . LYS   B 2 1   ? 22.38300  16.85900  21.77200  1.000 77.74896  ?  625 LYS   C C    1 
ATOM   2018 O  O    . LYS   B 2 1   ? 23.36900  16.25600  21.34300  1.000 84.35322  ?  625 LYS   C O    1 
ATOM   2019 C  CB   . LYS   B 2 1   ? 22.15300  19.30500  21.39700  1.000 95.79496  ?  625 LYS   C CB   1 
ATOM   2020 C  CG   . LYS   B 2 1   ? 22.14400  20.33800  20.30100  1.000 99.86267  ?  625 LYS   C CG   1 
ATOM   2021 C  CD   . LYS   B 2 1   ? 22.82500  19.82000  19.05200  1.000 93.23234  ?  625 LYS   C CD   1 
ATOM   2022 C  CE   . LYS   B 2 1   ? 23.03400  20.94600  18.06700  1.000 93.06102  ?  625 LYS   C CE   1 
ATOM   2023 N  NZ   . LYS   B 2 1   ? 21.73800  21.61900  17.73500  1.000 93.30776  ?  625 LYS   C NZ   1 
ATOM   2024 N  N    . ASN   B 2 2   ? 21.83900  16.63300  22.96800  1.000 65.66192  ?  626 ASN   C N    1 
ATOM   2025 C  CA   . ASN   B 2 2   ? 22.51200  15.89100  24.03200  1.000 55.87959  ?  626 ASN   C CA   1 
ATOM   2026 C  C    . ASN   B 2 2   ? 22.23400  14.39800  23.87900  1.000 41.88148  ?  626 ASN   C C    1 
ATOM   2027 O  O    . ASN   B 2 2   ? 21.43900  13.80300  24.60800  1.000 36.53504  ?  626 ASN   C O    1 
ATOM   2028 C  CB   . ASN   B 2 2   ? 22.03600  16.41400  25.37900  1.000 52.29885  ?  626 ASN   C CB   1 
ATOM   2029 C  CG   . ASN   B 2 2   ? 20.55100  16.74300  25.37300  1.000 65.90795  ?  626 ASN   C CG   1 
ATOM   2030 O  OD1  . ASN   B 2 2   ? 20.14300  17.83500  24.97200  1.000 64.44165  ?  626 ASN   C OD1  1 
ATOM   2031 N  ND2  . ASN   B 2 2   ? 19.73400  15.79000  25.80500  1.000 59.35188  ?  626 ASN   C ND2  1 
ATOM   2032 N  N    . HIS   B 2 3   ? 22.92800  13.77500  22.92600  1.000 30.26969  ?  627 HIS   C N    1 
ATOM   2033 C  CA   . HIS   B 2 3   ? 22.67300  12.37800  22.56300  1.000 28.57090  ?  627 HIS   C CA   1 
ATOM   2034 C  C    . HIS   B 2 3   ? 23.98200  11.65200  22.27600  1.000 23.58134  ?  627 HIS   C C    1 
ATOM   2035 O  O    . HIS   B 2 3   ? 24.24000  11.22300  21.14600  1.000 30.12849  ?  627 HIS   C O    1 
ATOM   2036 C  CB   . HIS   B 2 3   ? 21.72800  12.30600  21.36000  1.000 25.30767  ?  627 HIS   C CB   1 
ATOM   2037 C  CG   . HIS   B 2 3   ? 20.38400  12.91800  21.61100  1.000 25.03694  ?  627 HIS   C CG   1 
ATOM   2038 N  ND1  . HIS   B 2 3   ? 20.15200  14.27300  21.50000  1.000 26.52635  ?  627 HIS   C ND1  1 
ATOM   2039 C  CD2  . HIS   B 2 3   ? 19.20100  12.36200  21.96400  1.000 21.50707  ?  627 HIS   C CD2  1 
ATOM   2040 C  CE1  . HIS   B 2 3   ? 18.88500  14.52500  21.77700  1.000 23.24602  ?  627 HIS   C CE1  1 
ATOM   2041 N  NE2  . HIS   B 2 3   ? 18.28600  13.38300  22.06200  1.000 23.15060  ?  627 HIS   C NE2  1 
ATOM   2042 N  N    . PRO   B 2 4   ? 24.82400  11.46000  23.29900  1.000 27.19060  ?  628 PRO   C N    1 
ATOM   2043 C  CA   . PRO   B 2 4   ? 26.13700  10.84300  23.03500  1.000 24.64641  ?  628 PRO   C CA   1 
ATOM   2044 C  C    . PRO   B 2 4   ? 26.05900  9.39200   22.59100  1.000 26.95709  ?  628 PRO   C C    1 
ATOM   2045 O  O    . PRO   B 2 4   ? 26.84300  8.97100   21.73100  1.000 23.48153  ?  628 PRO   C O    1 
ATOM   2046 C  CB   . PRO   B 2 4   ? 26.86800  10.99100  24.37900  1.000 23.77908  ?  628 PRO   C CB   1 
ATOM   2047 C  CG   . PRO   B 2 4   ? 25.77800  11.11500  25.39500  1.000 27.09598  ?  628 PRO   C CG   1 
ATOM   2048 C  CD   . PRO   B 2 4   ? 24.68100  11.87400  24.70600  1.000 27.13948  ?  628 PRO   C CD   1 
ATOM   2049 N  N    A MET   B 2 5   ? 25.13900  8.60700   23.15600  0.460 24.16665  ?  629 MET   C N    1 
ATOM   2050 N  N    B MET   B 2 5   ? 25.13500  8.60900   23.15000  0.540 24.15672  ?  629 MET   C N    1 
ATOM   2051 C  CA   A MET   B 2 5   ? 25.03900  7.20100   22.77700  0.460 24.20124  ?  629 MET   C CA   1 
ATOM   2052 C  CA   B MET   B 2 5   ? 25.04600  7.20200   22.77400  0.540 24.19403  ?  629 MET   C CA   1 
ATOM   2053 C  C    A MET   B 2 5   ? 24.50400  7.05000   21.36000  0.460 22.90809  ?  629 MET   C C    1 
ATOM   2054 C  C    B MET   B 2 5   ? 24.49700  7.04200   21.36200  0.540 22.90528  ?  629 MET   C C    1 
ATOM   2055 O  O    A MET   B 2 5   ? 24.98100  6.20200   20.59600  0.460 23.72545  ?  629 MET   C O    1 
ATOM   2056 O  O    B MET   B 2 5   ? 24.96100  6.18300   20.60300  0.540 23.73476  ?  629 MET   C O    1 
ATOM   2057 C  CB   A MET   B 2 5   ? 24.15200  6.45400   23.77300  0.460 24.11193  ?  629 MET   C CB   1 
ATOM   2058 C  CB   B MET   B 2 5   ? 24.18400  6.44500   23.78500  0.540 24.13427  ?  629 MET   C CB   1 
ATOM   2059 C  CG   A MET   B 2 5   ? 24.76500  6.31800   25.15700  0.460 23.58160  ?  629 MET   C CG   1 
ATOM   2060 C  CG   B MET   B 2 5   ? 24.82200  6.33700   25.16300  0.540 23.52006  ?  629 MET   C CG   1 
ATOM   2061 S  SD   A MET   B 2 5   ? 23.55700  5.85400   26.41100  0.460 27.00970  ?  629 MET   C SD   1 
ATOM   2062 S  SD   B MET   B 2 5   ? 23.76200  5.52700   26.37500  0.540 29.07969  ?  629 MET   C SD   1 
ATOM   2063 C  CE   A MET   B 2 5   ? 24.48100  6.20800   27.90200  0.460 20.72943  ?  629 MET   C CE   1 
ATOM   2064 C  CE   B MET   B 2 5   ? 22.69100  6.88000   26.84000  0.540 15.16673  ?  629 MET   C CE   1 
ATOM   2065 N  N    . LEU   B 2 6   ? 23.50900  7.86000   20.99500  1.000 17.38446  ?  630 LEU   C N    1 
ATOM   2066 C  CA   . LEU   B 2 6   ? 22.99100  7.84500   19.63100  1.000 20.90843  ?  630 LEU   C CA   1 
ATOM   2067 C  C    . LEU   B 2 6   ? 24.06500  8.28100   18.64100  1.000 21.56109  ?  630 LEU   C C    1 
ATOM   2068 O  O    . LEU   B 2 6   ? 24.26600  7.64400   17.60200  1.000 23.18182  ?  630 LEU   C O    1 
ATOM   2069 C  CB   . LEU   B 2 6   ? 21.76500  8.75800   19.54800  1.000 22.13172  ?  630 LEU   C CB   1 
ATOM   2070 C  CG   . LEU   B 2 6   ? 20.98800  8.96300   18.24600  1.000 31.51170  ?  630 LEU   C CG   1 
ATOM   2071 C  CD1  . LEU   B 2 6   ? 20.71400  7.65400   17.54700  1.000 32.58645  ?  630 LEU   C CD1  1 
ATOM   2072 C  CD2  . LEU   B 2 6   ? 19.68100  9.69100   18.53600  1.000 24.40710  ?  630 LEU   C CD2  1 
ATOM   2073 N  N    . MET   B 2 7   ? 24.77900  9.36200   18.96500  1.000 22.64830  ?  631 MET   C N    1 
ATOM   2074 C  CA   . MET   B 2 7   ? 25.85200  9.84000   18.09700  1.000 22.75418  ?  631 MET   C CA   1 
ATOM   2075 C  C    . MET   B 2 7   ? 26.93900  8.78800   17.92800  1.000 34.02019  ?  631 MET   C C    1 
ATOM   2076 O  O    . MET   B 2 7   ? 27.46400  8.59600   16.82400  1.000 30.42197  ?  631 MET   C O    1 
ATOM   2077 C  CB   . MET   B 2 7   ? 26.44400  11.12700  18.66900  1.000 28.49195  ?  631 MET   C CB   1 
ATOM   2078 C  CG   . MET   B 2 7   ? 25.68500  12.40200  18.32600  1.000 35.31050  ?  631 MET   C CG   1 
ATOM   2079 S  SD   . MET   B 2 7   ? 26.16600  13.11600  16.73700  1.000 50.60348  ?  631 MET   C SD   1 
ATOM   2080 C  CE   . MET   B 2 7   ? 25.14800  12.18600  15.59200  1.000 37.91566  ?  631 MET   C CE   1 
ATOM   2081 N  N    . ASN   B 2 8   ? 27.29700  8.10300   19.01800  1.000 27.66036  ?  632 ASN   C N    1 
ATOM   2082 C  CA   . ASN   B 2 8   ? 28.33900  7.08300   18.95400  1.000 24.85008  ?  632 ASN   C CA   1 
ATOM   2083 C  C    . ASN   B 2 8   ? 27.95300  5.95400   18.00900  1.000 27.50340  ?  632 ASN   C C    1 
ATOM   2084 O  O    . ASN   B 2 8   ? 28.79000  5.45800   17.24600  1.000 28.24577  ?  632 ASN   C O    1 
ATOM   2085 C  CB   . ASN   B 2 8   ? 28.61000  6.54000   20.35800  1.000 26.74506  ?  632 ASN   C CB   1 
ATOM   2086 C  CG   . ASN   B 2 8   ? 29.69500  5.48900   20.37400  1.000 38.83942  ?  632 ASN   C CG   1 
ATOM   2087 O  OD1  . ASN   B 2 8   ? 29.41500  4.29500   20.48000  1.000 38.44583  ?  632 ASN   C OD1  1 
ATOM   2088 N  ND2  . ASN   B 2 8   ? 30.94400  5.92700   20.26900  1.000 41.76652  ?  632 ASN   C ND2  1 
ATOM   2089 N  N    . LEU   B 2 9   ? 26.68600  5.53500   18.04400  1.000 20.65685  ?  633 LEU   C N    1 
ATOM   2090 C  CA   . LEU   B 2 9   ? 26.22900  4.47700   17.14900  1.000 22.09401  ?  633 LEU   C CA   1 
ATOM   2091 C  C    . LEU   B 2 9   ? 26.11600  4.96800   15.71300  1.000 20.20923  ?  633 LEU   C C    1 
ATOM   2092 O  O    . LEU   B 2 9   ? 26.23000  4.16800   14.77600  1.000 33.40969  ?  633 LEU   C O    1 
ATOM   2093 C  CB   . LEU   B 2 9   ? 24.88800  3.92800   17.63100  1.000 20.55219  ?  633 LEU   C CB   1 
ATOM   2094 C  CG   . LEU   B 2 9   ? 24.93800  3.30400   19.02700  1.000 30.14817  ?  633 LEU   C CG   1 
ATOM   2095 C  CD1  . LEU   B 2 9   ? 23.53600  3.06800   19.57100  1.000 26.71706  ?  633 LEU   C CD1  1 
ATOM   2096 C  CD2  . LEU   B 2 9   ? 25.73800  2.01000   18.99400  1.000 24.21567  ?  633 LEU   C CD2  1 
ATOM   2097 N  N    . LEU   B 2 10  ? 25.87200  6.26500   15.52300  1.000 20.90184  ?  634 LEU   C N    1 
ATOM   2098 C  CA   . LEU   B 2 10  ? 25.93000  6.85800   14.19300  1.000 38.35957  ?  634 LEU   C CA   1 
ATOM   2099 C  C    . LEU   B 2 10  ? 27.36300  7.04700   13.72200  1.000 44.58172  ?  634 LEU   C C    1 
ATOM   2100 O  O    . LEU   B 2 10  ? 27.59200  7.14800   12.51200  1.000 46.85233  ?  634 LEU   C O    1 
ATOM   2101 C  CB   . LEU   B 2 10  ? 25.20700  8.21000   14.18600  1.000 29.56553  ?  634 LEU   C CB   1 
ATOM   2102 C  CG   . LEU   B 2 10  ? 23.67900  8.19500   14.10200  1.000 32.67250  ?  634 LEU   C CG   1 
ATOM   2103 C  CD1  . LEU   B 2 10  ? 23.10200  9.59200   14.27500  1.000 30.74171  ?  634 LEU   C CD1  1 
ATOM   2104 C  CD2  . LEU   B 2 10  ? 23.20700  7.57900   12.79300  1.000 27.07578  ?  634 LEU   C CD2  1 
ATOM   2105 N  N    . LYS   B 2 11  ? 28.31100  7.07900   14.66000  1.000 46.19503  ?  635 LYS   C N    1 
ATOM   2106 C  CA   . LYS   B 2 11  ? 29.72900  7.37000   14.43000  1.000 48.48722  ?  635 LYS   C CA   1 
ATOM   2107 C  C    . LYS   B 2 11  ? 29.92500  8.83100   14.06100  1.000 55.12782  ?  635 LYS   C C    1 
ATOM   2108 O  O    . LYS   B 2 11  ? 29.91800  9.70400   14.93100  1.000 53.25983  ?  635 LYS   C O    1 
ATOM   2109 C  CB   . LYS   B 2 11  ? 30.32000  6.46700   13.34400  1.000 39.15127  ?  635 LYS   C CB   1 
ATOM   2110 C  CG   . LYS   B 2 11  ? 31.14500  5.31300   13.88800  1.000 57.45163  ?  635 LYS   C CG   1 
ATOM   2111 C  CD   . LYS   B 2 11  ? 30.26700  4.13000   14.25300  1.000 54.57208  ?  635 LYS   C CD   1 
ATOM   2112 C  CE   . LYS   B 2 11  ? 30.31700  3.07500   13.16600  1.000 51.16681  ?  635 LYS   C CE   1 
ATOM   2113 N  NZ   . LYS   B 2 11  ? 29.61100  1.82600   13.55800  1.000 59.92321  ?  635 LYS   C NZ   1 
ATOM   2114 N  N    . LYS   C 1 18  ? 27.41500  -4.07500  79.46100  1.000 41.20395  ?  123 LYS   B N    1 
ATOM   2115 C  CA   . LYS   C 1 18  ? 27.92200  -2.68700  79.53500  1.000 33.04754  ?  123 LYS   B CA   1 
ATOM   2116 C  C    . LYS   C 1 18  ? 27.30700  -1.84600  78.41300  1.000 22.92841  ?  123 LYS   B C    1 
ATOM   2117 O  O    . LYS   C 1 18  ? 27.54000  -0.68400  78.40100  1.000 30.52255  ?  123 LYS   B O    1 
ATOM   2118 C  CB   . LYS   C 1 18  ? 29.44500  -2.65200  79.56800  1.000 36.08608  ?  123 LYS   B CB   1 
ATOM   2119 C  CG   . LYS   C 1 18  ? 30.12600  -3.89500  80.10400  1.000 33.18517  ?  123 LYS   B CG   1 
ATOM   2120 C  CD   . LYS   C 1 18  ? 31.49300  -3.57300  80.60000  1.000 47.16580  ?  123 LYS   B CD   1 
ATOM   2121 C  CE   . LYS   C 1 18  ? 32.12100  -2.53000  79.70900  1.000 52.29782  ?  123 LYS   B CE   1 
ATOM   2122 N  NZ   . LYS   C 1 18  ? 33.09700  -3.14300  78.78400  1.000 39.66911  ?  123 LYS   B NZ   1 
ATOM   2123 N  N    . LEU   C 1 19  ? 26.59400  -2.45800  77.47400  1.000 24.60062  ?  124 LEU   B N    1 
ATOM   2124 C  CA   . LEU   C 1 19  ? 25.87200  -1.69500  76.46600  1.000 18.62274  ?  124 LEU   B CA   1 
ATOM   2125 C  C    . LEU   C 1 19  ? 24.66900  -1.02300  77.11700  1.000 13.05966  ?  124 LEU   B C    1 
ATOM   2126 O  O    . LEU   C 1 19  ? 23.91800  -1.66300  77.85800  1.000 25.11016  ?  124 LEU   B O    1 
ATOM   2127 C  CB   . LEU   C 1 19  ? 25.41600  -2.60200  75.32300  1.000 18.98901  ?  124 LEU   B CB   1 
ATOM   2128 C  CG   . LEU   C 1 19  ? 26.47100  -3.13000  74.35300  1.000 26.62068  ?  124 LEU   B CG   1 
ATOM   2129 C  CD1  . LEU   C 1 19  ? 25.90200  -4.28700  73.54600  1.000 31.15463  ?  124 LEU   B CD1  1 
ATOM   2130 C  CD2  . LEU   C 1 19  ? 26.96100  -2.02300  73.43000  1.000 22.49371  ?  124 LEU   B CD2  1 
ATOM   2131 N  N    . SER   C 1 20  ? 24.49400  0.27000   76.85800  1.000 20.37450  ?  125 SER   B N    1 
ATOM   2132 C  CA   . SER   C 1 20  ? 23.31200  0.95700   77.34800  1.000 22.12799  ?  125 SER   B CA   1 
ATOM   2133 C  C    . SER   C 1 20  ? 22.07800  0.48900   76.58000  1.000 24.07685  ?  125 SER   B C    1 
ATOM   2134 O  O    . SER   C 1 20  ? 22.17800  -0.15600  75.53400  1.000 22.99965  ?  125 SER   B O    1 
ATOM   2135 C  CB   . SER   C 1 20  ? 23.47400  2.47100   77.21300  1.000 23.76488  ?  125 SER   B CB   1 
ATOM   2136 O  OG   . SER   C 1 20  ? 23.41000  2.87300   75.85400  1.000 23.53335  ?  125 SER   B OG   1 
ATOM   2137 N  N    . GLU   C 1 21  ? 20.89900  0.81200   77.12200  1.000 24.40242  ?  126 GLU   B N    1 
ATOM   2138 C  CA   . GLU   C 1 21  ? 19.65500  0.53100   76.40800  1.000 30.43677  ?  126 GLU   B CA   1 
ATOM   2139 C  C    . GLU   C 1 21  ? 19.68800  1.12800   75.01000  1.000 17.52132  ?  126 GLU   B C    1 
ATOM   2140 O  O    . GLU   C 1 21  ? 19.34800  0.46300   74.02400  1.000 21.14441  ?  126 GLU   B O    1 
ATOM   2141 C  CB   . GLU   C 1 21  ? 18.45400  1.09700   77.16500  1.000 28.48952  ?  126 GLU   B CB   1 
ATOM   2142 C  CG   . GLU   C 1 21  ? 18.06200  0.38700   78.43000  1.000 46.50465  ?  126 GLU   B CG   1 
ATOM   2143 C  CD   . GLU   C 1 21  ? 16.89400  1.08100   79.10200  1.000 50.19093  ?  126 GLU   B CD   1 
ATOM   2144 O  OE1  . GLU   C 1 21  ? 15.83500  1.21800   78.45200  1.000 43.81077  ?  126 GLU   B OE1  1 
ATOM   2145 O  OE2  . GLU   C 1 21  ? 17.03800  1.50800   80.26600  1.000 48.24306  ?  126 GLU   B OE2  1 
ATOM   2146 N  N    . GLU   C 1 22  ? 20.07900  2.40100   74.91900  1.000 20.76769  ?  127 GLU   B N    1 
ATOM   2147 C  CA   . GLU   C 1 22  ? 20.14400  3.09400   73.63800  1.000 25.11684  ?  127 GLU   B CA   1 
ATOM   2148 C  C    . GLU   C 1 22  ? 21.07900  2.38200   72.66900  1.000 23.19040  ?  127 GLU   B C    1 
ATOM   2149 O  O    . GLU   C 1 22  ? 20.76900  2.25200   71.47900  1.000 19.46373  ?  127 GLU   B O    1 
ATOM   2150 C  CB   . GLU   C 1 22  ? 20.59800  4.53500   73.87000  1.000 27.08211  ?  127 GLU   B CB   1 
ATOM   2151 C  CG   . GLU   C 1 22  ? 20.80300  5.36800   72.62400  1.000 32.55634  ?  127 GLU   B CG   1 
ATOM   2152 C  CD   . GLU   C 1 22  ? 21.28100  6.77200   72.95300  1.000 50.30704  ?  127 GLU   B CD   1 
ATOM   2153 O  OE1  . GLU   C 1 22  ? 21.94300  6.94500   74.00100  1.000 48.81848  ?  127 GLU   B OE1  1 
ATOM   2154 O  OE2  . GLU   C 1 22  ? 20.99700  7.70000   72.16900  1.000 49.02113  ?  127 GLU   B OE2  1 
ATOM   2155 N  N    . GLN   C 1 23  ? 22.22600  1.90800   73.16300  1.000 20.35153  ?  128 GLN   B N    1 
ATOM   2156 C  CA   . GLN   C 1 23  ? 23.17900  1.22200   72.29500  1.000 17.96287  ?  128 GLN   B CA   1 
ATOM   2157 C  C    . GLN   C 1 23  ? 22.64200  -0.13300  71.84400  1.000 14.24353  ?  128 GLN   B C    1 
ATOM   2158 O  O    . GLN   C 1 23  ? 22.81400  -0.51500  70.68100  1.000 13.48165  ?  128 GLN   B O    1 
ATOM   2159 C  CB   . GLN   C 1 23  ? 24.52400  1.07300   73.01100  1.000 21.85208  ?  128 GLN   B CB   1 
ATOM   2160 C  CG   . GLN   C 1 23  ? 25.20400  2.41100   73.29700  1.000 21.00115  ?  128 GLN   B CG   1 
ATOM   2161 C  CD   . GLN   C 1 23  ? 26.45500  2.28100   74.14900  1.000 22.66233  ?  128 GLN   B CD   1 
ATOM   2162 O  OE1  . GLN   C 1 23  ? 26.60700  1.33000   74.91500  1.000 17.93714  ?  128 GLN   B OE1  1 
ATOM   2163 N  NE2  . GLN   C 1 23  ? 27.35800  3.24600   74.01800  1.000 23.30452  ?  128 GLN   B NE2  1 
ATOM   2164 N  N    . GLN   C 1 24  ? 21.98800  -0.87300  72.74500  1.000 14.98312  ?  129 GLN   B N    1 
ATOM   2165 C  CA   . GLN   C 1 24  ? 21.33600  -2.11500  72.33500  1.000 12.71907  ?  129 GLN   B CA   1 
ATOM   2166 C  C    . GLN   C 1 24  ? 20.25000  -1.84200  71.30400  1.000 14.15064  ?  129 GLN   B C    1 
ATOM   2167 O  O    . GLN   C 1 24  ? 20.09800  -2.59200  70.33200  1.000 14.77947  ?  129 GLN   B O    1 
ATOM   2168 C  CB   . GLN   C 1 24  ? 20.74100  -2.83500  73.54600  1.000 14.80900  ?  129 GLN   B CB   1 
ATOM   2169 C  CG   . GLN   C 1 24  ? 21.73100  -3.15300  74.65900  1.000 17.18482  ?  129 GLN   B CG   1 
ATOM   2170 C  CD   . GLN   C 1 24  ? 21.04100  -3.65600  75.91300  1.000 26.71000  ?  129 GLN   B CD   1 
ATOM   2171 O  OE1  . GLN   C 1 24  ? 20.04400  -4.37100  75.83900  1.000 30.68383  ?  129 GLN   B OE1  1 
ATOM   2172 N  NE2  . GLN   C 1 24  ? 21.56000  -3.27100  77.07300  1.000 29.17738  ?  129 GLN   B NE2  1 
ATOM   2173 N  N    . HIS   C 1 25  ? 19.47800  -0.77400  71.51500  1.000 15.66975  ?  130 HIS   B N    1 
ATOM   2174 C  CA   . HIS   C 1 25  ? 18.44200  -0.37900  70.56500  1.000 17.88568  ?  130 HIS   B CA   1 
ATOM   2175 C  C    . HIS   C 1 25  ? 19.03200  -0.11900  69.18400  1.000 15.34289  ?  130 HIS   B C    1 
ATOM   2176 O  O    . HIS   C 1 25  ? 18.53500  -0.63600  68.17500  1.000 17.27628  ?  130 HIS   B O    1 
ATOM   2177 C  CB   . HIS   C 1 25  ? 17.73100  0.86700   71.08600  1.000 22.05920  ?  130 HIS   B CB   1 
ATOM   2178 C  CG   . HIS   C 1 25  ? 16.48600  1.21800   70.33700  1.000 33.81897  ?  130 HIS   B CG   1 
ATOM   2179 N  ND1  . HIS   C 1 25  ? 15.46300  0.31900   70.12600  1.000 40.08454  ?  130 HIS   B ND1  1 
ATOM   2180 C  CD2  . HIS   C 1 25  ? 16.09700  2.37500   69.75100  1.000 40.08723  ?  130 HIS   B CD2  1 
ATOM   2181 C  CE1  . HIS   C 1 25  ? 14.50000  0.90700   69.44000  1.000 27.23176  ?  130 HIS   B CE1  1 
ATOM   2182 N  NE2  . HIS   C 1 25  ? 14.85800  2.15600   69.20300  1.000 54.73538  ?  130 HIS   B NE2  1 
ATOM   2183 N  N    . ILE   C 1 26  ? 20.08500  0.70100   69.12400  1.000 13.38938  ?  131 ILE   B N    1 
ATOM   2184 C  CA   . ILE   C 1 26  ? 20.75500  0.98900   67.85700  1.000 15.30118  ?  131 ILE   B CA   1 
ATOM   2185 C  C    . ILE   C 1 26  ? 21.15200  -0.30500  67.15900  1.000 15.51589  ?  131 ILE   B C    1 
ATOM   2186 O  O    . ILE   C 1 26  ? 20.84200  -0.51600  65.98100  1.000 15.31824  ?  131 ILE   B O    1 
ATOM   2187 C  CB   . ILE   C 1 26  ? 21.97100  1.90300   68.09700  1.000 16.85188  ?  131 ILE   B CB   1 
ATOM   2188 C  CG1  . ILE   C 1 26  ? 21.50300  3.30900   68.48700  1.000 19.66353  ?  131 ILE   B CG1  1 
ATOM   2189 C  CG2  . ILE   C 1 26  ? 22.86700  1.95000   66.86900  1.000 14.08862  ?  131 ILE   B CG2  1 
ATOM   2190 C  CD1  . ILE   C 1 26  ? 22.60800  4.20600   68.99500  1.000 17.09398  ?  131 ILE   B CD1  1 
ATOM   2191 N  N    . ILE   C 1 27  ? 21.81900  -1.20600  67.88500  1.000 15.00965  ?  132 ILE   B N    1 
ATOM   2192 C  CA   . ILE   C 1 27  ? 22.28400  -2.45000  67.27000  1.000 16.46073  ?  132 ILE   B CA   1 
ATOM   2193 C  C    . ILE   C 1 27  ? 21.10600  -3.27300  66.75700  1.000 15.51425  ?  132 ILE   B C    1 
ATOM   2194 O  O    . ILE   C 1 27  ? 21.14200  -3.81200  65.64200  1.000 14.66452  ?  132 ILE   B O    1 
ATOM   2195 C  CB   . ILE   C 1 27  ? 23.14900  -3.24400  68.26800  1.000 13.91677  ?  132 ILE   B CB   1 
ATOM   2196 C  CG1  . ILE   C 1 27  ? 24.48500  -2.52600  68.48800  1.000 17.46595  ?  132 ILE   B CG1  1 
ATOM   2197 C  CG2  . ILE   C 1 27  ? 23.37400  -4.65600  67.76600  1.000 16.82966  ?  132 ILE   B CG2  1 
ATOM   2198 C  CD1  . ILE   C 1 27  ? 25.31800  -3.10500  69.61700  1.000 22.00034  ?  132 ILE   B CD1  1 
ATOM   2199 N  N    . ALA   C 1 28  ? 20.04000  -3.37100  67.55300  1.000 12.16101  ?  133 ALA   B N    1 
ATOM   2200 C  CA   . ALA   C 1 28  ? 18.86400  -4.12800  67.12900  1.000 16.35259  ?  133 ALA   B CA   1 
ATOM   2201 C  C    . ALA   C 1 28  ? 18.29200  -3.58100  65.82400  1.000 12.56627  ?  133 ALA   B C    1 
ATOM   2202 O  O    . ALA   C 1 28  ? 17.92500  -4.34800  64.92400  1.000 15.97203  ?  133 ALA   B O    1 
ATOM   2203 C  CB   . ALA   C 1 28  ? 17.80300  -4.10000  68.22700  1.000 15.33549  ?  133 ALA   B CB   1 
ATOM   2204 N  N    . ILE   C 1 29  ? 18.21100  -2.25700  65.70400  1.000 14.39256  ?  134 ILE   B N    1 
ATOM   2205 C  CA   . ILE   C 1 29  ? 17.66000  -1.64600  64.49800  1.000 14.86025  ?  134 ILE   B CA   1 
ATOM   2206 C  C    . ILE   C 1 29  ? 18.54400  -1.94300  63.29300  1.000 18.10590  ?  134 ILE   B C    1 
ATOM   2207 O  O    . ILE   C 1 29  ? 18.04800  -2.24100  62.20000  1.000 16.60260  ?  134 ILE   B O    1 
ATOM   2208 C  CB   . ILE   C 1 29  ? 17.47700  -0.13200  64.71200  1.000 18.47300  ?  134 ILE   B CB   1 
ATOM   2209 C  CG1  . ILE   C 1 29  ? 16.34200  0.12600   65.70800  1.000 19.39235  ?  134 ILE   B CG1  1 
ATOM   2210 C  CG2  . ILE   C 1 29  ? 17.18800  0.57100   63.39600  1.000 15.71202  ?  134 ILE   B CG2  1 
ATOM   2211 C  CD1  . ILE   C 1 29  ? 16.33200  1.53600   66.27200  1.000 23.35798  ?  134 ILE   B CD1  1 
ATOM   2212 N  N    . LEU   C 1 30  ? 19.85600  -1.85500  63.46300  1.000 11.28359  ?  135 LEU   B N    1 
ATOM   2213 C  CA   . LEU   C 1 30  ? 20.79600  -2.08900  62.32800  1.000 15.48004  ?  135 LEU   B CA   1 
ATOM   2214 C  C    . LEU   C 1 30  ? 20.78800  -3.56000  61.89300  1.000 18.04485  ?  135 LEU   B C    1 
ATOM   2215 O  O    . LEU   C 1 30  ? 20.85100  -3.80900  60.73600  1.000 14.30145  ?  135 LEU   B O    1 
ATOM   2216 C  CB   . LEU   C 1 30  ? 22.20000  -1.62000  62.69900  1.000 14.60683  ?  135 LEU   B CB   1 
ATOM   2217 C  CG   . LEU   C 1 30  ? 22.31100  -0.12200  62.96000  1.000 16.37807  ?  135 LEU   B CG   1 
ATOM   2218 C  CD1  . LEU   C 1 30  ? 23.73300  0.26300   63.31000  1.000 15.41671  ?  135 LEU   B CD1  1 
ATOM   2219 C  CD2  . LEU   C 1 30  ? 21.85200  0.65200   61.74900  1.000 16.81619  ?  135 LEU   B CD2  1 
ATOM   2220 N  N    . LEU   C 1 31  ? 20.70500  -4.47400  62.84900  1.000 15.84756  ?  136 LEU   B N    1 
ATOM   2221 C  CA   . LEU   C 1 31  ? 20.65100  -5.88700  62.48000  1.000 15.74909  ?  136 LEU   B CA   1 
ATOM   2222 C  C    . LEU   C 1 31  ? 19.37400  -6.20000  61.70900  1.000 12.90579  ?  136 LEU   B C    1 
ATOM   2223 O  O    . LEU   C 1 31  ? 19.40600  -6.88100  60.67800  1.000 15.46035  ?  136 LEU   B O    1 
ATOM   2224 C  CB   . LEU   C 1 31  ? 20.75700  -6.76500  63.72800  1.000 16.69168  ?  136 LEU   B CB   1 
ATOM   2225 C  CG   . LEU   C 1 31  ? 22.13200  -6.84500  64.39900  1.000 17.87304  ?  136 LEU   B CG   1 
ATOM   2226 C  CD1  . LEU   C 1 31  ? 22.04000  -7.58400  65.72600  1.000 19.98940  ?  136 LEU   B CD1  1 
ATOM   2227 C  CD2  . LEU   C 1 31  ? 23.14700  -7.50900  63.47800  1.000 18.65139  ?  136 LEU   B CD2  1 
ATOM   2228 N  N    . ASP   C 1 32  ? 18.23400  -5.70000  62.19600  1.000 16.11280  ?  137 ASP   B N    1 
ATOM   2229 C  CA   . ASP   C 1 32  ? 16.98100  -5.85300  61.46200  1.000 17.99117  ?  137 ASP   B CA   1 
ATOM   2230 C  C    . ASP   C 1 32  ? 17.07000  -5.21900  60.07800  1.000 19.38194  ?  137 ASP   B C    1 
ATOM   2231 O  O    . ASP   C 1 32  ? 16.60100  -5.79600  59.08900  1.000 16.79781  ?  137 ASP   B O    1 
ATOM   2232 C  CB   . ASP   C 1 32  ? 15.83200  -5.23600  62.26000  1.000 12.98140  ?  137 ASP   B CB   1 
ATOM   2233 C  CG   . ASP   C 1 32  ? 14.52200  -5.24000  61.49500  1.000 27.50454  ?  137 ASP   B CG   1 
ATOM   2234 O  OD1  . ASP   C 1 32  ? 14.10000  -4.16000  61.03200  1.000 23.28023  ?  137 ASP   B OD1  1 
ATOM   2235 O  OD2  . ASP   C 1 32  ? 13.91500  -6.32300  61.35700  1.000 24.38950  ?  137 ASP   B OD2  1 
ATOM   2236 N  N    . ALA   C 1 33  ? 17.66900  -4.02900  59.98900  1.000 12.06486  ?  138 ALA   B N    1 
ATOM   2237 C  CA   . ALA   C 1 33  ? 17.81100  -3.35600  58.69900  1.000 11.75420  ?  138 ALA   B CA   1 
ATOM   2238 C  C    . ALA   C 1 33  ? 18.64100  -4.18500  57.72700  1.000 16.38656  ?  138 ALA   B C    1 
ATOM   2239 O  O    . ALA   C 1 33  ? 18.29200  -4.31300  56.54600  1.000 17.58739  ?  138 ALA   B O    1 
ATOM   2240 C  CB   . ALA   C 1 33  ? 18.44900  -1.98500  58.89900  1.000 11.45207  ?  138 ALA   B CB   1 
ATOM   2241 N  N    . HIS   C 1 34  ? 19.75600  -4.73600  58.20200  1.000 15.84212  ?  139 HIS   B N    1 
ATOM   2242 C  CA   . HIS   C 1 34  ? 20.59400  -5.57600  57.35400  1.000 14.20952  ?  139 HIS   B CA   1 
ATOM   2243 C  C    . HIS   C 1 34  ? 19.84800  -6.82600  56.90700  1.000 20.51197  ?  139 HIS   B C    1 
ATOM   2244 O  O    . HIS   C 1 34  ? 19.91200  -7.21300  55.73400  1.000 19.55473  ?  139 HIS   B O    1 
ATOM   2245 C  CB   . HIS   C 1 34  ? 21.86500  -5.95400  58.11000  1.000 16.12407  ?  139 HIS   B CB   1 
ATOM   2246 C  CG   . HIS   C 1 34  ? 22.85800  -6.71100  57.28900  1.000 17.35077  ?  139 HIS   B CG   1 
ATOM   2247 N  ND1  . HIS   C 1 34  ? 23.31000  -6.26300  56.06600  1.000 15.86591  ?  139 HIS   B ND1  1 
ATOM   2248 C  CD2  . HIS   C 1 34  ? 23.48900  -7.88700  57.51700  1.000 22.28882  ?  139 HIS   B CD2  1 
ATOM   2249 C  CE1  . HIS   C 1 34  ? 24.17900  -7.13000  55.57700  1.000 22.92654  ?  139 HIS   B CE1  1 
ATOM   2250 N  NE2  . HIS   C 1 34  ? 24.30700  -8.12400  56.43900  1.000 19.95934  ?  139 HIS   B NE2  1 
ATOM   2251 N  N    . HIS   C 1 35  ? 19.12600  -7.46900  57.82700  1.000 18.05468  ?  140 HIS   B N    1 
ATOM   2252 C  CA   . HIS   C 1 35  ? 18.39300  -8.67900  57.47500  1.000 18.78387  ?  140 HIS   B CA   1 
ATOM   2253 C  C    . HIS   C 1 35  ? 17.30300  -8.39500  56.44800  1.000 20.83115  ?  140 HIS   B C    1 
ATOM   2254 O  O    . HIS   C 1 35  ? 16.99200  -9.25800  55.61700  1.000 24.27241  ?  140 HIS   B O    1 
ATOM   2255 C  CB   . HIS   C 1 35  ? 17.80400  -9.30900  58.73800  1.000 19.09565  ?  140 HIS   B CB   1 
ATOM   2256 C  CG   . HIS   C 1 35  ? 18.84200  -9.72700  59.73300  1.000 23.02437  ?  140 HIS   B CG   1 
ATOM   2257 N  ND1  . HIS   C 1 35  ? 18.55200  -9.97300  61.05800  1.000 25.53785  ?  140 HIS   B ND1  1 
ATOM   2258 C  CD2  . HIS   C 1 35  ? 20.17400  -9.93600  59.59400  1.000 29.23726  ?  140 HIS   B CD2  1 
ATOM   2259 C  CE1  . HIS   C 1 35  ? 19.65900  -10.31800 61.69200  1.000 25.35066  ?  140 HIS   B CE1  1 
ATOM   2260 N  NE2  . HIS   C 1 35  ? 20.65700  -10.30400 60.82700  1.000 29.44063  ?  140 HIS   B NE2  1 
ATOM   2261 N  N    . LYS   C 1 36  ? 16.72500  -7.19200  56.47900  1.000 18.30311  ?  141 LYS   B N    1 
ATOM   2262 C  CA   . LYS   C 1 36  ? 15.71000  -6.81000  55.50600  1.000 21.30624  ?  141 LYS   B CA   1 
ATOM   2263 C  C    . LYS   C 1 36  ? 16.28900  -6.49500  54.13400  1.000 23.83226  ?  141 LYS   B C    1 
ATOM   2264 O  O    . LYS   C 1 36  ? 15.54800  -6.52600  53.14700  1.000 23.83593  ?  141 LYS   B O    1 
ATOM   2265 C  CB   . LYS   C 1 36  ? 14.92700  -5.59200  56.00500  1.000 17.74894  ?  141 LYS   B CB   1 
ATOM   2266 C  CG   . LYS   C 1 36  ? 13.92400  -5.88200  57.11000  1.000 28.19700  ?  141 LYS   B CG   1 
ATOM   2267 C  CD   . LYS   C 1 36  ? 13.30000  -4.59000  57.61600  1.000 29.54478  ?  141 LYS   B CD   1 
ATOM   2268 C  CE   . LYS   C 1 36  ? 11.84500  -4.78000  58.01700  1.000 48.96837  ?  141 LYS   B CE   1 
ATOM   2269 N  NZ   . LYS   C 1 36  ? 11.69600  -5.19900  59.44200  1.000 35.29008  ?  141 LYS   B NZ   1 
ATOM   2270 N  N    . THR   C 1 37  ? 17.58800  -6.20100  54.04400  1.000 16.72675  ?  142 THR   B N    1 
ATOM   2271 C  CA   . THR   C 1 37  ? 18.18500  -5.68100  52.81800  1.000 22.11874  ?  142 THR   B CA   1 
ATOM   2272 C  C    . THR   C 1 37  ? 19.33700  -6.53200  52.29300  1.000 28.41808  ?  142 THR   B C    1 
ATOM   2273 O  O    . THR   C 1 37  ? 19.99200  -6.13100  51.32300  1.000 23.80828  ?  142 THR   B O    1 
ATOM   2274 C  CB   . THR   C 1 37  ? 18.67200  -4.24100  53.03400  1.000 18.69257  ?  142 THR   B CB   1 
ATOM   2275 O  OG1  . THR   C 1 37  ? 19.60000  -4.21100  54.12500  1.000 19.24871  ?  142 THR   B OG1  1 
ATOM   2276 C  CG2  . THR   C 1 37  ? 17.49900  -3.31700  53.34800  1.000 19.32996  ?  142 THR   B CG2  1 
ATOM   2277 N  N    . TYR   C 1 38  ? 19.61400  -7.68300  52.90300  1.000 21.28815  ?  143 TYR   B N    1 
ATOM   2278 C  CA   . TYR   C 1 38  ? 20.62600  -8.60400  52.39600  1.000 21.28632  ?  143 TYR   B CA   1 
ATOM   2279 C  C    . TYR   C 1 38  ? 20.03000  -10.00200 52.34200  1.000 24.26687  ?  143 TYR   B C    1 
ATOM   2280 O  O    . TYR   C 1 38  ? 19.69000  -10.57500 53.38200  1.000 20.03247  ?  143 TYR   B O    1 
ATOM   2281 C  CB   . TYR   C 1 38  ? 21.89300  -8.58200  53.25800  1.000 18.42214  ?  143 TYR   B CB   1 
ATOM   2282 C  CG   . TYR   C 1 38  ? 23.05100  -9.34600  52.64800  1.000 25.60719  ?  143 TYR   B CG   1 
ATOM   2283 C  CD1  . TYR   C 1 38  ? 23.12000  -10.73200 52.73900  1.000 26.79024  ?  143 TYR   B CD1  1 
ATOM   2284 C  CD2  . TYR   C 1 38  ? 24.06900  -8.68300  51.97200  1.000 23.13129  ?  143 TYR   B CD2  1 
ATOM   2285 C  CE1  . TYR   C 1 38  ? 24.16600  -11.43400 52.18000  1.000 27.75873  ?  143 TYR   B CE1  1 
ATOM   2286 C  CE2  . TYR   C 1 38  ? 25.12200  -9.37900  51.40800  1.000 25.01415  ?  143 TYR   B CE2  1 
ATOM   2287 C  CZ   . TYR   C 1 38  ? 25.16300  -10.75600 51.51500  1.000 35.22867  ?  143 TYR   B CZ   1 
ATOM   2288 O  OH   . TYR   C 1 38  ? 26.20800  -11.46000 50.96100  1.000 37.28098  ?  143 TYR   B OH   1 
ATOM   2289 N  N    . ASP   C 1 39  ? 19.92100  -10.55100 51.13200  1.000 25.51047  ?  144 ASP   B N    1 
ATOM   2290 C  CA   . ASP   C 1 39  ? 19.34500  -11.86500 50.88100  1.000 28.61423  ?  144 ASP   B CA   1 
ATOM   2291 C  C    . ASP   C 1 39  ? 20.47400  -12.86000 50.64800  1.000 25.65291  ?  144 ASP   B C    1 
ATOM   2292 O  O    . ASP   C 1 39  ? 21.01200  -12.92700 49.53100  1.000 23.10467  ?  144 ASP   B O    1 
ATOM   2293 C  CB   . ASP   C 1 39  ? 18.41300  -11.80900 49.66700  1.000 25.43561  ?  144 ASP   B CB   1 
ATOM   2294 C  CG   . ASP   C 1 39  ? 17.77300  -13.15200 49.33700  1.000 31.08001  ?  144 ASP   B CG   1 
ATOM   2295 O  OD1  . ASP   C 1 39  ? 17.01000  -13.20100 48.35200  1.000 34.02907  ?  144 ASP   B OD1  1 
ATOM   2296 O  OD2  . ASP   C 1 39  ? 18.01500  -14.15100 50.05000  1.000 25.90285  ?  144 ASP   B OD2  1 
ATOM   2297 N  N    . PRO   C 1 40  ? 20.86100  -13.66200 51.64500  1.000 21.05905  ?  145 PRO   B N    1 
ATOM   2298 C  CA   . PRO   C 1 40  ? 21.98400  -14.59300 51.45800  1.000 26.37633  ?  145 PRO   B CA   1 
ATOM   2299 C  C    . PRO   C 1 40  ? 21.66900  -15.78300 50.56300  1.000 29.31893  ?  145 PRO   B C    1 
ATOM   2300 O  O    . PRO   C 1 40  ? 22.55500  -16.61600 50.34400  1.000 33.55548  ?  145 PRO   B O    1 
ATOM   2301 C  CB   . PRO   C 1 40  ? 22.30200  -15.05000 52.89000  1.000 27.68776  ?  145 PRO   B CB   1 
ATOM   2302 C  CG   . PRO   C 1 40  ? 21.01800  -14.90900 53.62000  1.000 31.24347  ?  145 PRO   B CG   1 
ATOM   2303 C  CD   . PRO   C 1 40  ? 20.29500  -13.73500 53.00400  1.000 26.35716  ?  145 PRO   B CD   1 
ATOM   2304 N  N    . THR   C 1 41  ? 20.44500  -15.90100 50.04500  1.000 28.66130  ?  146 THR   B N    1 
ATOM   2305 C  CA   . THR   C 1 41  ? 20.15400  -16.90200 49.02700  1.000 26.65815  ?  146 THR   B CA   1 
ATOM   2306 C  C    . THR   C 1 41  ? 20.44600  -16.40300 47.62000  1.000 35.55860  ?  146 THR   B C    1 
ATOM   2307 O  O    . THR   C 1 41  ? 20.59100  -17.22200 46.70500  1.000 33.65076  ?  146 THR   B O    1 
ATOM   2308 C  CB   . THR   C 1 41  ? 18.69100  -17.35300 49.10900  1.000 34.75191  ?  146 THR   B CB   1 
ATOM   2309 O  OG1  . THR   C 1 41  ? 17.84700  -16.38000 48.47600  1.000 34.50451  ?  146 THR   B OG1  1 
ATOM   2310 C  CG2  . THR   C 1 41  ? 18.26800  -17.53100 50.56000  1.000 26.27724  ?  146 THR   B CG2  1 
ATOM   2311 N  N    . TYR   C 1 42  ? 20.53900  -15.08200 47.43500  1.000 32.88553  ?  147 TYR   B N    1 
ATOM   2312 C  CA   . TYR   C 1 42  ? 20.89300  -14.47300 46.15300  1.000 24.46395  ?  147 TYR   B CA   1 
ATOM   2313 C  C    . TYR   C 1 42  ? 19.91300  -14.86000 45.05200  1.000 27.10521  ?  147 TYR   B C    1 
ATOM   2314 O  O    . TYR   C 1 42  ? 20.27300  -14.91100 43.87300  1.000 27.74519  ?  147 TYR   B O    1 
ATOM   2315 C  CB   . TYR   C 1 42  ? 22.32500  -14.83200 45.75400  1.000 26.71564  ?  147 TYR   B CB   1 
ATOM   2316 C  CG   . TYR   C 1 42  ? 23.30700  -14.57900 46.86900  1.000 29.85153  ?  147 TYR   B CG   1 
ATOM   2317 C  CD1  . TYR   C 1 42  ? 23.91900  -15.63100 47.53400  1.000 34.56544  ?  147 TYR   B CD1  1 
ATOM   2318 C  CD2  . TYR   C 1 42  ? 23.60400  -13.28400 47.27300  1.000 30.01615  ?  147 TYR   B CD2  1 
ATOM   2319 C  CE1  . TYR   C 1 42  ? 24.81400  -15.40000 48.56000  1.000 28.65993  ?  147 TYR   B CE1  1 
ATOM   2320 C  CE2  . TYR   C 1 42  ? 24.49400  -13.04400 48.29900  1.000 34.71955  ?  147 TYR   B CE2  1 
ATOM   2321 C  CZ   . TYR   C 1 42  ? 25.09600  -14.10400 48.93900  1.000 33.71191  ?  147 TYR   B CZ   1 
ATOM   2322 O  OH   . TYR   C 1 42  ? 25.98600  -13.86700 49.96200  1.000 37.24243  ?  147 TYR   B OH   1 
ATOM   2323 N  N    . ALA   C 1 43  ? 18.66300  -15.12500 45.43800  1.000 26.68564  ?  148 ALA   B N    1 
ATOM   2324 C  CA   . ALA   C 1 43  ? 17.65700  -15.53400 44.46800  1.000 30.71311  ?  148 ALA   B CA   1 
ATOM   2325 C  C    . ALA   C 1 43  ? 17.46600  -14.48900 43.37800  1.000 38.33899  ?  148 ALA   B C    1 
ATOM   2326 O  O    . ALA   C 1 43  ? 17.23700  -14.84800 42.22200  1.000 35.00718  ?  148 ALA   B O    1 
ATOM   2327 C  CB   . ALA   C 1 43  ? 16.33100  -15.81600 45.17500  1.000 41.50235  ?  148 ALA   B CB   1 
ATOM   2328 N  N    . ASP   C 1 44  ? 17.58500  -13.20200 43.71400  1.000 27.36223  ?  149 ASP   B N    1 
ATOM   2329 C  CA   . ASP   C 1 44  ? 17.29800  -12.14800 42.74600  1.000 28.09063  ?  149 ASP   B CA   1 
ATOM   2330 C  C    . ASP   C 1 44  ? 18.30700  -12.08600 41.60600  1.000 26.55218  ?  149 ASP   B C    1 
ATOM   2331 O  O    . ASP   C 1 44  ? 18.02400  -11.43700 40.59100  1.000 30.07041  ?  149 ASP   B O    1 
ATOM   2332 C  CB   . ASP   C 1 44  ? 17.23000  -10.79300 43.45100  1.000 32.92872  ?  149 ASP   B CB   1 
ATOM   2333 C  CG   . ASP   C 1 44  ? 16.07700  -10.70700 44.43400  1.000 43.22906  ?  149 ASP   B CG   1 
ATOM   2334 O  OD1  . ASP   C 1 44  ? 15.13900  -11.52200 44.31800  1.000 38.93061  ?  149 ASP   B OD1  1 
ATOM   2335 O  OD2  . ASP   C 1 44  ? 16.10700  -9.82300  45.31900  1.000 33.43406  ?  149 ASP   B OD2  1 
ATOM   2336 N  N    . PHE   C 1 45  ? 19.45900  -12.75100 41.73400  1.000 22.64544  ?  150 PHE   B N    1 
ATOM   2337 C  CA   . PHE   C 1 45  ? 20.46700  -12.71500 40.68200  1.000 23.17697  ?  150 PHE   B CA   1 
ATOM   2338 C  C    . PHE   C 1 45  ? 19.95800  -13.34000 39.38900  1.000 28.65621  ?  150 PHE   B C    1 
ATOM   2339 O  O    . PHE   C 1 45  ? 20.49400  -13.04800 38.31400  1.000 25.92396  ?  150 PHE   B O    1 
ATOM   2340 C  CB   . PHE   C 1 45  ? 21.74400  -13.42700 41.14600  1.000 25.87716  ?  150 PHE   B CB   1 
ATOM   2341 C  CG   . PHE   C 1 45  ? 22.54100  -12.66400 42.18600  1.000 21.92149  ?  150 PHE   B CG   1 
ATOM   2342 C  CD1  . PHE   C 1 45  ? 21.90700  -11.91000 43.16600  1.000 29.68842  ?  150 PHE   B CD1  1 
ATOM   2343 C  CD2  . PHE   C 1 45  ? 23.92700  -12.71800 42.19000  1.000 22.73714  ?  150 PHE   B CD2  1 
ATOM   2344 C  CE1  . PHE   C 1 45  ? 22.63500  -11.22000 44.11900  1.000 29.80818  ?  150 PHE   B CE1  1 
ATOM   2345 C  CE2  . PHE   C 1 45  ? 24.66100  -12.02900 43.14200  1.000 25.34329  ?  150 PHE   B CE2  1 
ATOM   2346 C  CZ   . PHE   C 1 45  ? 24.01500  -11.28100 44.10700  1.000 29.35240  ?  150 PHE   B CZ   1 
ATOM   2347 N  N    . ARG   C 1 46  ? 18.92900  -14.18800 39.47500  1.000 28.83500  ?  151 ARG   B N    1 
ATOM   2348 C  CA   . ARG   C 1 46  ? 18.30200  -14.76100 38.28600  1.000 31.09234  ?  151 ARG   B CA   1 
ATOM   2349 C  C    . ARG   C 1 46  ? 17.77100  -13.68900 37.34800  1.000 28.51025  ?  151 ARG   B C    1 
ATOM   2350 O  O    . ARG   C 1 46  ? 17.66800  -13.92200 36.13800  1.000 33.29806  ?  151 ARG   B O    1 
ATOM   2351 C  CB   . ARG   C 1 46  ? 17.14600  -15.67500 38.70300  1.000 34.11783  ?  151 ARG   B CB   1 
ATOM   2352 C  CG   . ARG   C 1 46  ? 16.12400  -14.94700 39.56700  1.000 41.78187  ?  151 ARG   B CG   1 
ATOM   2353 C  CD   . ARG   C 1 46  ? 14.67400  -15.34800 39.32600  1.000 63.84382  ?  151 ARG   B CD   1 
ATOM   2354 N  NE   . ARG   C 1 46  ? 13.77500  -14.73100 40.30700  1.000 67.14127  ?  151 ARG   B NE   1 
ATOM   2355 C  CZ   . ARG   C 1 46  ? 13.81500  -14.93800 41.62400  1.000 68.64156  ?  151 ARG   B CZ   1 
ATOM   2356 N  NH1  . ARG   C 1 46  ? 14.69100  -15.78100 42.15600  1.000 67.80939  ?  151 ARG   B NH1  1 
ATOM   2357 N  NH2  . ARG   C 1 46  ? 12.95600  -14.30900 42.41600  1.000 65.13980  ?  151 ARG   B NH2  1 
ATOM   2358 N  N    . ASP   C 1 47  ? 17.41000  -12.52200 37.88500  1.000 27.63849  ?  152 ASP   B N    1 
ATOM   2359 C  CA   . ASP   C 1 47  ? 16.76900  -11.46300 37.12100  1.000 26.99448  ?  152 ASP   B CA   1 
ATOM   2360 C  C    . ASP   C 1 47  ? 17.75700  -10.56900 36.39100  1.000 25.48614  ?  152 ASP   B C    1 
ATOM   2361 O  O    . ASP   C 1 47  ? 17.33300  -9.75800  35.56200  1.000 25.13729  ?  152 ASP   B O    1 
ATOM   2362 C  CB   . ASP   C 1 47  ? 15.90300  -10.59400 38.03800  1.000 25.84863  ?  152 ASP   B CB   1 
ATOM   2363 C  CG   . ASP   C 1 47  ? 14.69400  -11.33000 38.56700  1.000 42.07126  ?  152 ASP   B CG   1 
ATOM   2364 O  OD1  . ASP   C 1 47  ? 14.46900  -12.47700 38.13500  1.000 36.63142  ?  152 ASP   B OD1  1 
ATOM   2365 O  OD2  . ASP   C 1 47  ? 13.97800  -10.76800 39.42400  1.000 42.71819  ?  152 ASP   B OD2  1 
ATOM   2366 N  N    . PHE   C 1 48  ? 19.04700  -10.68500 36.68500  1.000 22.80786  ?  153 PHE   B N    1 
ATOM   2367 C  CA   . PHE   C 1 48  ? 20.04500  -9.85900  36.02900  1.000 19.17545  ?  153 PHE   B CA   1 
ATOM   2368 C  C    . PHE   C 1 48  ? 20.27100  -10.34400 34.60400  1.000 29.11783  ?  153 PHE   B C    1 
ATOM   2369 O  O    . PHE   C 1 48  ? 19.94700  -11.48000 34.24500  1.000 26.93997  ?  153 PHE   B O    1 
ATOM   2370 C  CB   . PHE   C 1 48  ? 21.37700  -9.89600  36.78500  1.000 18.94360  ?  153 PHE   B CB   1 
ATOM   2371 C  CG   . PHE   C 1 48  ? 21.28500  -9.47800  38.23200  1.000 21.44174  ?  153 PHE   B CG   1 
ATOM   2372 C  CD1  . PHE   C 1 48  ? 22.30400  -9.79600  39.11500  1.000 20.39272  ?  153 PHE   B CD1  1 
ATOM   2373 C  CD2  . PHE   C 1 48  ? 20.19800  -8.76000  38.70700  1.000 21.13903  ?  153 PHE   B CD2  1 
ATOM   2374 C  CE1  . PHE   C 1 48  ? 22.23900  -9.41600  40.44200  1.000 21.38856  ?  153 PHE   B CE1  1 
ATOM   2375 C  CE2  . PHE   C 1 48  ? 20.12400  -8.38000  40.03900  1.000 21.26102  ?  153 PHE   B CE2  1 
ATOM   2376 C  CZ   . PHE   C 1 48  ? 21.15000  -8.70800  40.90300  1.000 19.58282  ?  153 PHE   B CZ   1 
ATOM   2377 N  N    . ARG   C 1 49  ? 20.84200  -9.47100  33.78900  1.000 21.65633  ?  154 ARG   B N    1 
ATOM   2378 C  CA   . ARG   C 1 49  ? 21.38400  -9.92700  32.52300  1.000 26.16382  ?  154 ARG   B CA   1 
ATOM   2379 C  C    . ARG   C 1 49  ? 22.40700  -11.02000 32.81500  1.000 26.58359  ?  154 ARG   B C    1 
ATOM   2380 O  O    . ARG   C 1 49  ? 23.21100  -10.87400 33.74500  1.000 25.01089  ?  154 ARG   B O    1 
ATOM   2381 C  CB   . ARG   C 1 49  ? 22.01100  -8.76800  31.75200  1.000 22.54845  ?  154 ARG   B CB   1 
ATOM   2382 C  CG   . ARG   C 1 49  ? 20.96000  -7.82400  31.17600  1.000 23.04035  ?  154 ARG   B CG   1 
ATOM   2383 C  CD   . ARG   C 1 49  ? 21.56300  -6.53000  30.66100  1.000 25.06473  ?  154 ARG   B CD   1 
ATOM   2384 N  NE   . ARG   C 1 49  ? 22.00600  -5.65600  31.74200  1.000 21.25064  ?  154 ARG   B NE   1 
ATOM   2385 C  CZ   . ARG   C 1 49  ? 22.78100  -4.59000  31.56100  1.000 30.43354  ?  154 ARG   B CZ   1 
ATOM   2386 N  NH1  . ARG   C 1 49  ? 23.19100  -4.27100  30.34100  1.000 21.90261  ?  154 ARG   B NH1  1 
ATOM   2387 N  NH2  . ARG   C 1 49  ? 23.14100  -3.84000  32.59300  1.000 25.26990  ?  154 ARG   B NH2  1 
ATOM   2388 N  N    . PRO   C 1 50  ? 22.37200  -12.14400 32.09700  1.000 27.81969  ?  155 PRO   B N    1 
ATOM   2389 C  CA   . PRO   C 1 50  ? 23.16800  -13.29400 32.51400  1.000 28.60636  ?  155 PRO   B CA   1 
ATOM   2390 C  C    . PRO   C 1 50  ? 24.65200  -12.99600 32.42200  1.000 30.72933  ?  155 PRO   B C    1 
ATOM   2391 O  O    . PRO   C 1 50  ? 25.08700  -12.16600 31.60500  1.000 27.53364  ?  155 PRO   B O    1 
ATOM   2392 C  CB   . PRO   C 1 50  ? 22.75700  -14.39200 31.51500  1.000 35.60288  ?  155 PRO   B CB   1 
ATOM   2393 C  CG   . PRO   C 1 50  ? 22.16000  -13.66200 30.36700  1.000 33.77412  ?  155 PRO   B CG   1 
ATOM   2394 C  CD   . PRO   C 1 50  ? 21.50000  -12.45900 30.95600  1.000 30.81991  ?  155 PRO   B CD   1 
ATOM   2395 N  N    . PRO   C 1 51  ? 25.46900  -13.64300 33.24800  1.000 31.24457  ?  156 PRO   B N    1 
ATOM   2396 C  CA   . PRO   C 1 51  ? 26.91700  -13.52900 33.07600  1.000 33.00173  ?  156 PRO   B CA   1 
ATOM   2397 C  C    . PRO   C 1 51  ? 27.35600  -14.26700 31.82400  1.000 46.70437  ?  156 PRO   B C    1 
ATOM   2398 O  O    . PRO   C 1 51  ? 26.73200  -15.24200 31.39700  1.000 39.90278  ?  156 PRO   B O    1 
ATOM   2399 C  CB   . PRO   C 1 51  ? 27.48000  -14.18400 34.34100  1.000 30.09950  ?  156 PRO   B CB   1 
ATOM   2400 C  CG   . PRO   C 1 51  ? 26.43000  -15.16300 34.75300  1.000 33.17506  ?  156 PRO   B CG   1 
ATOM   2401 C  CD   . PRO   C 1 51  ? 25.10100  -14.59500 34.31400  1.000 28.54665  ?  156 PRO   B CD   1 
ATOM   2402 N  N    . VAL   C 1 52  ? 28.43000  -13.76800 31.21800  1.000 29.93315  ?  157 VAL   B N    1 
ATOM   2403 C  CA   . VAL   C 1 52  ? 29.03400  -14.38000 30.04000  1.000 40.58585  ?  157 VAL   B CA   1 
ATOM   2404 C  C    . VAL   C 1 52  ? 30.54200  -14.28200 30.20900  1.000 35.86136  ?  157 VAL   B C    1 
ATOM   2405 O  O    . VAL   C 1 52  ? 31.07700  -13.18100 30.38500  1.000 34.97472  ?  157 VAL   B O    1 
ATOM   2406 C  CB   . VAL   C 1 52  ? 28.59000  -13.69900 28.73000  1.000 35.26012  ?  157 VAL   B CB   1 
ATOM   2407 C  CG1  . VAL   C 1 52  ? 29.36800  -14.25700 27.54900  1.000 39.76147  ?  157 VAL   B CG1  1 
ATOM   2408 C  CG2  . VAL   C 1 52  ? 27.09000  -13.87000 28.50800  1.000 35.76481  ?  157 VAL   B CG2  1 
ATOM   2409 N  N    . ARG   C 1 53  ? 31.23000  -15.42500 30.17000  1.000 47.04730  ?  158 ARG   B N    1 
ATOM   2410 C  CA   . ARG   C 1 53  ? 32.65300  -15.47200 30.47800  1.000 42.80112  ?  158 ARG   B CA   1 
ATOM   2411 C  C    . ARG   C 1 53  ? 33.52100  -16.00400 29.34800  1.000 70.78772  ?  158 ARG   B C    1 
ATOM   2412 O  O    . ARG   C 1 53  ? 34.73800  -16.11700 29.53800  1.000 71.01324  ?  158 ARG   B O    1 
ATOM   2413 C  CB   . ARG   C 1 53  ? 32.89700  -16.32600 31.72900  1.000 51.75333  ?  158 ARG   B CB   1 
ATOM   2414 C  CG   . ARG   C 1 53  ? 32.59200  -15.62900 33.03800  1.000 44.68280  ?  158 ARG   B CG   1 
ATOM   2415 C  CD   . ARG   C 1 53  ? 32.21200  -16.64400 34.09900  1.000 45.40994  ?  158 ARG   B CD   1 
ATOM   2416 N  NE   . ARG   C 1 53  ? 31.91200  -16.01800 35.38300  1.000 44.87730  ?  158 ARG   B NE   1 
ATOM   2417 C  CZ   . ARG   C 1 53  ? 30.72800  -16.08200 35.98000  1.000 42.74173  ?  158 ARG   B CZ   1 
ATOM   2418 N  NH1  . ARG   C 1 53  ? 29.73100  -16.74100 35.40600  1.000 34.49044  ?  158 ARG   B NH1  1 
ATOM   2419 N  NH2  . ARG   C 1 53  ? 30.53900  -15.48700 37.14900  1.000 36.95737  ?  158 ARG   B NH2  1 
ATOM   2420 N  N    . MET   C 1 54  ? 32.93600  -16.33200 28.19600  1.000 61.88601  ?  159 MET   B N    1 
ATOM   2421 C  CA   . MET   C 1 54  ? 33.62900  -16.94100 27.05100  1.000 79.55461  ?  159 MET   B CA   1 
ATOM   2422 C  C    . MET   C 1 54  ? 35.08700  -16.51700 26.86200  1.000 82.73447  ?  159 MET   B C    1 
ATOM   2423 O  O    . MET   C 1 54  ? 36.00500  -17.16600 27.37000  1.000 84.94644  ?  159 MET   B O    1 
ATOM   2424 C  CB   . MET   C 1 54  ? 32.85800  -16.62800 25.76700  1.000 80.86342  ?  159 MET   B CB   1 
ATOM   2425 C  CG   . MET   C 1 54  ? 32.95300  -17.70300 24.69800  1.000 95.38737  ?  159 MET   B CG   1 
ATOM   2426 S  SD   . MET   C 1 54  ? 31.35600  -18.05000 23.93500  1.000 112.36624 ?  159 MET   B SD   1 
ATOM   2427 C  CE   . MET   C 1 54  ? 30.78100  -16.38800 23.59300  1.000 104.98885 ?  159 MET   B CE   1 
ATOM   2428 N  N    . SER   C 1 66  ? 33.30000  -7.68200  22.32700  1.000 86.95377  ?  218 SER   B N    1 
ATOM   2429 C  CA   . SER   C 1 66  ? 34.26100  -7.00800  23.19300  1.000 69.81379  ?  218 SER   B CA   1 
ATOM   2430 C  C    . SER   C 1 66  ? 34.54000  -7.83500  24.44800  1.000 68.13438  ?  218 SER   B C    1 
ATOM   2431 O  O    . SER   C 1 66  ? 33.71800  -8.66100  24.84500  1.000 71.73989  ?  218 SER   B O    1 
ATOM   2432 C  CB   . SER   C 1 66  ? 33.75500  -5.61100  23.56800  1.000 72.16320  ?  218 SER   B CB   1 
ATOM   2433 O  OG   . SER   C 1 66  ? 34.26800  -4.63400  22.67700  1.000 79.86620  ?  218 SER   B OG   1 
ATOM   2434 N  N    . PRO   C 1 67  ? 35.70900  -7.62300  25.06300  1.000 61.60595  ?  219 PRO   B N    1 
ATOM   2435 C  CA   . PRO   C 1 67  ? 36.07200  -8.42000  26.24700  1.000 56.84829  ?  219 PRO   B CA   1 
ATOM   2436 C  C    . PRO   C 1 67  ? 35.29200  -8.06400  27.50100  1.000 41.23086  ?  219 PRO   B C    1 
ATOM   2437 O  O    . PRO   C 1 67  ? 35.46100  -8.74900  28.51800  1.000 45.28901  ?  219 PRO   B O    1 
ATOM   2438 C  CB   . PRO   C 1 67  ? 37.56900  -8.12400  26.43300  1.000 51.79840  ?  219 PRO   B CB   1 
ATOM   2439 C  CG   . PRO   C 1 67  ? 38.01100  -7.45200  25.17400  1.000 58.40484  ?  219 PRO   B CG   1 
ATOM   2440 C  CD   . PRO   C 1 67  ? 36.81300  -6.75200  24.63300  1.000 58.95633  ?  219 PRO   B CD   1 
ATOM   2441 N  N    . LEU   C 1 68  ? 34.45700  -7.03000  27.47500  1.000 40.26847  ?  220 LEU   B N    1 
ATOM   2442 C  CA   . LEU   C 1 68  ? 33.69400  -6.64300  28.66200  1.000 28.87928  ?  220 LEU   B CA   1 
ATOM   2443 C  C    . LEU   C 1 68  ? 32.38500  -7.42100  28.76000  1.000 27.94690  ?  220 LEU   B C    1 
ATOM   2444 O  O    . LEU   C 1 68  ? 31.30800  -6.85800  28.95200  1.000 24.28093  ?  220 LEU   B O    1 
ATOM   2445 C  CB   . LEU   C 1 68  ? 33.44800  -5.13800  28.66100  1.000 31.90241  ?  220 LEU   B CB   1 
ATOM   2446 C  CG   . LEU   C 1 68  ? 34.69000  -4.24900  28.52200  1.000 27.70041  ?  220 LEU   B CG   1 
ATOM   2447 C  CD1  . LEU   C 1 68  ? 34.37500  -2.80600  28.88200  1.000 33.32425  ?  220 LEU   B CD1  1 
ATOM   2448 C  CD2  . LEU   C 1 68  ? 35.84100  -4.77200  29.36800  1.000 26.73963  ?  220 LEU   B CD2  1 
ATOM   2449 N  N    . SER   C 1 69  ? 32.48900  -8.74800  28.64200  1.000 21.83970  ?  221 SER   B N    1 
ATOM   2450 C  CA   . SER   C 1 69  ? 31.30700  -9.60200  28.60100  1.000 24.95039  ?  221 SER   B CA   1 
ATOM   2451 C  C    . SER   C 1 69  ? 30.61900  -9.71700  29.95500  1.000 26.56538  ?  221 SER   B C    1 
ATOM   2452 O  O    . SER   C 1 69  ? 29.45100  -10.11800 30.00700  1.000 22.10896  ?  221 SER   B O    1 
ATOM   2453 C  CB   . SER   C 1 69  ? 31.68500  -10.99400 28.09000  1.000 24.90034  ?  221 SER   B CB   1 
ATOM   2454 O  OG   . SER   C 1 69  ? 32.57200  -11.64200 28.98400  1.000 30.70815  ?  221 SER   B OG   1 
ATOM   2455 N  N    . MET   C 1 70  ? 31.30800  -9.38500  31.04500  1.000 23.72219  ?  222 MET   B N    1 
ATOM   2456 C  CA   . MET   C 1 70  ? 30.70200  -9.39500  32.37100  1.000 21.53858  ?  222 MET   B CA   1 
ATOM   2457 C  C    . MET   C 1 70  ? 30.16800  -8.03300  32.79000  1.000 23.16935  ?  222 MET   B C    1 
ATOM   2458 O  O    . MET   C 1 70  ? 29.61500  -7.91800  33.88900  1.000 26.88307  ?  222 MET   B O    1 
ATOM   2459 C  CB   . MET   C 1 70  ? 31.70900  -9.88800  33.41700  1.000 20.50599  ?  222 MET   B CB   1 
ATOM   2460 C  CG   . MET   C 1 70  ? 31.96400  -11.38400 33.36400  1.000 22.66416  ?  222 MET   B CG   1 
ATOM   2461 S  SD   . MET   C 1 70  ? 30.46300  -12.34000 33.67000  1.000 28.38646  ?  222 MET   B SD   1 
ATOM   2462 C  CE   . MET   C 1 70  ? 30.33600  -12.17000 35.45300  1.000 25.74735  ?  222 MET   B CE   1 
ATOM   2463 N  N    . LEU   C 1 71  ? 30.31800  -7.00400  31.95200  1.000 22.25881  ?  223 LEU   B N    1 
ATOM   2464 C  CA   . LEU   C 1 71  ? 29.80900  -5.68000  32.30900  1.000 18.43281  ?  223 LEU   B CA   1 
ATOM   2465 C  C    . LEU   C 1 71  ? 28.29500  -5.64800  32.47200  1.000 21.33698  ?  223 LEU   B C    1 
ATOM   2466 O  O    . LEU   C 1 71  ? 27.82100  -5.07500  33.46800  1.000 23.69557  ?  223 LEU   B O    1 
ATOM   2467 C  CB   . LEU   C 1 71  ? 30.28200  -4.64100  31.28400  1.000 21.83651  ?  223 LEU   B CB   1 
ATOM   2468 C  CG   . LEU   C 1 71  ? 29.87800  -3.18800  31.55600  1.000 21.66495  ?  223 LEU   B CG   1 
ATOM   2469 C  CD1  . LEU   C 1 71  ? 30.26900  -2.76400  32.96700  1.000 22.52595  ?  223 LEU   B CD1  1 
ATOM   2470 C  CD2  . LEU   C 1 71  ? 30.48500  -2.24700  30.51900  1.000 18.58359  ?  223 LEU   B CD2  1 
ATOM   2471 N  N    . PRO   C 1 72  ? 27.48200  -6.21000  31.56400  1.000 20.20915  ?  224 PRO   B N    1 
ATOM   2472 C  CA   . PRO   C 1 72  ? 26.02600  -6.18200  31.80200  1.000 26.93650  ?  224 PRO   B CA   1 
ATOM   2473 C  C    . PRO   C 1 72  ? 25.61400  -6.83600  33.11200  1.000 18.81176  ?  224 PRO   B C    1 
ATOM   2474 O  O    . PRO   C 1 72  ? 24.86500  -6.23400  33.89200  1.000 18.84401  ?  224 PRO   B O    1 
ATOM   2475 C  CB   . PRO   C 1 72  ? 25.46400  -6.92400  30.58200  1.000 23.90041  ?  224 PRO   B CB   1 
ATOM   2476 C  CG   . PRO   C 1 72  ? 26.47300  -6.68100  29.51100  1.000 26.09252  ?  224 PRO   B CG   1 
ATOM   2477 C  CD   . PRO   C 1 72  ? 27.79700  -6.72800  30.21600  1.000 24.85869  ?  224 PRO   B CD   1 
ATOM   2478 N  N    . HIS   C 1 73  ? 26.09600  -8.05100  33.38200  1.000 22.18798  ?  225 HIS   B N    1 
ATOM   2479 C  CA   . HIS   C 1 73  ? 25.68300  -8.75600  34.59300  1.000 23.75382  ?  225 HIS   B CA   1 
ATOM   2480 C  C    . HIS   C 1 73  ? 26.14900  -8.02600  35.84700  1.000 20.03341  ?  225 HIS   B C    1 
ATOM   2481 O  O    . HIS   C 1 73  ? 25.39600  -7.90500  36.82000  1.000 17.93416  ?  225 HIS   B O    1 
ATOM   2482 C  CB   . HIS   C 1 73  ? 26.21900  -10.18700 34.57900  1.000 24.31756  ?  225 HIS   B CB   1 
ATOM   2483 C  CG   . HIS   C 1 73  ? 25.95400  -10.94400 35.84300  1.000 23.95798  ?  225 HIS   B CG   1 
ATOM   2484 N  ND1  . HIS   C 1 73  ? 24.72500  -11.49500 36.13700  1.000 22.72175  ?  225 HIS   B ND1  1 
ATOM   2485 C  CD2  . HIS   C 1 73  ? 26.75900  -11.24100 36.89100  1.000 20.10292  ?  225 HIS   B CD2  1 
ATOM   2486 C  CE1  . HIS   C 1 73  ? 24.78500  -12.10100 37.31000  1.000 26.02956  ?  225 HIS   B CE1  1 
ATOM   2487 N  NE2  . HIS   C 1 73  ? 26.00900  -11.96200 37.78800  1.000 20.41792  ?  225 HIS   B NE2  1 
ATOM   2488 N  N    . LEU   C 1 74  ? 27.38500  -7.52400  35.84200  1.000 17.64618  ?  226 LEU   B N    1 
ATOM   2489 C  CA   . LEU   C 1 74  ? 27.91700  -6.88600  37.04100  1.000 18.72656  ?  226 LEU   B CA   1 
ATOM   2490 C  C    . LEU   C 1 74  ? 27.39000  -5.46800  37.21900  1.000 24.17712  ?  226 LEU   B C    1 
ATOM   2491 O  O    . LEU   C 1 74  ? 27.33300  -4.97200  38.35000  1.000 19.07151  ?  226 LEU   B O    1 
ATOM   2492 C  CB   . LEU   C 1 74  ? 29.44600  -6.89100  37.00900  1.000 17.87328  ?  226 LEU   B CB   1 
ATOM   2493 C  CG   . LEU   C 1 74  ? 30.09100  -8.26800  37.19900  1.000 26.87303  ?  226 LEU   B CG   1 
ATOM   2494 C  CD1  . LEU   C 1 74  ? 31.60600  -8.15600  37.23100  1.000 23.69121  ?  226 LEU   B CD1  1 
ATOM   2495 C  CD2  . LEU   C 1 74  ? 29.57000  -8.95000  38.46400  1.000 20.00496  ?  226 LEU   B CD2  1 
ATOM   2496 N  N    . ALA   C 1 75  ? 27.00700  -4.79900  36.12900  1.000 17.67126  ?  227 ALA   B N    1 
ATOM   2497 C  CA   . ALA   C 1 75  ? 26.30200  -3.53100  36.26800  1.000 13.86798  ?  227 ALA   B CA   1 
ATOM   2498 C  C    . ALA   C 1 75  ? 24.94800  -3.74100  36.93100  1.000 16.55384  ?  227 ALA   B C    1 
ATOM   2499 O  O    . ALA   C 1 75  ? 24.54100  -2.95700  37.79700  1.000 15.20885  ?  227 ALA   B O    1 
ATOM   2500 C  CB   . ALA   C 1 75  ? 26.13400  -2.86400  34.90200  1.000 12.56966  ?  227 ALA   B CB   1 
ATOM   2501 N  N    . ASP   C 1 76  ? 24.24200  -4.80800  36.54500  1.000 15.50249  ?  228 ASP   B N    1 
ATOM   2502 C  CA   . ASP   C 1 76  ? 22.96700  -5.12100  37.18400  1.000 18.92048  ?  228 ASP   B CA   1 
ATOM   2503 C  C    . ASP   C 1 76  ? 23.15800  -5.44800  38.66100  1.000 19.55923  ?  228 ASP   B C    1 
ATOM   2504 O  O    . ASP   C 1 76  ? 22.36600  -5.01800  39.50600  1.000 16.26367  ?  228 ASP   B O    1 
ATOM   2505 C  CB   . ASP   C 1 76  ? 22.28600  -6.28700  36.46500  1.000 14.79087  ?  228 ASP   B CB   1 
ATOM   2506 C  CG   . ASP   C 1 76  ? 21.72200  -5.89500  35.10900  1.000 23.33381  ?  228 ASP   B CG   1 
ATOM   2507 O  OD1  . ASP   C 1 76  ? 21.46000  -6.80000  34.29100  1.000 23.67074  ?  228 ASP   B OD1  1 
ATOM   2508 O  OD2  . ASP   C 1 76  ? 21.53700  -4.68600  34.86300  1.000 23.56890  ?  228 ASP   B OD2  1 
ATOM   2509 N  N    . LEU   C 1 77  ? 24.20200  -6.21200  38.98700  1.000 14.14494  ?  229 LEU   B N    1 
ATOM   2510 C  CA   . LEU   C 1 77  ? 24.48700  -6.54100  40.38100  1.000 15.96188  ?  229 LEU   B CA   1 
ATOM   2511 C  C    . LEU   C 1 77  ? 24.74300  -5.28300  41.20300  1.000 20.30045  ?  229 LEU   B C    1 
ATOM   2512 O  O    . LEU   C 1 77  ? 24.20300  -5.12300  42.30500  1.000 17.47336  ?  229 LEU   B O    1 
ATOM   2513 C  CB   . LEU   C 1 77  ? 25.68800  -7.48800  40.45000  1.000 19.07962  ?  229 LEU   B CB   1 
ATOM   2514 C  CG   . LEU   C 1 77  ? 26.31200  -7.74900  41.82600  1.000 24.22707  ?  229 LEU   B CG   1 
ATOM   2515 C  CD1  . LEU   C 1 77  ? 25.29300  -8.33500  42.78900  1.000 16.74003  ?  229 LEU   B CD1  1 
ATOM   2516 C  CD2  . LEU   C 1 77  ? 27.52400  -8.66500  41.70300  1.000 22.80269  ?  229 LEU   B CD2  1 
ATOM   2517 N  N    . VAL   C 1 78  ? 25.56500  -4.37300  40.67700  1.000 15.02073  ?  230 VAL   B N    1 
ATOM   2518 C  CA   . VAL   C 1 78  ? 25.87700  -3.14400  41.40100  1.000 17.63864  ?  230 VAL   B CA   1 
ATOM   2519 C  C    . VAL   C 1 78  ? 24.63600  -2.26800  41.53500  1.000 14.47552  ?  230 VAL   B C    1 
ATOM   2520 O  O    . VAL   C 1 78  ? 24.38100  -1.68600  42.59700  1.000 16.44733  ?  230 VAL   B O    1 
ATOM   2521 C  CB   . VAL   C 1 78  ? 27.03300  -2.40500  40.70100  1.000 17.31089  ?  230 VAL   B CB   1 
ATOM   2522 C  CG1  . VAL   C 1 78  ? 27.18100  -0.99500  41.24100  1.000 20.59783  ?  230 VAL   B CG1  1 
ATOM   2523 C  CG2  . VAL   C 1 78  ? 28.33500  -3.18600  40.86600  1.000 16.90821  ?  230 VAL   B CG2  1 
ATOM   2524 N  N    . SER   C 1 79  ? 23.83400  -2.17400  40.47100  1.000 14.48045  ?  231 SER   B N    1 
ATOM   2525 C  CA   . SER   C 1 79  ? 22.61800  -1.37000  40.53300  1.000 19.19997  ?  231 SER   B CA   1 
ATOM   2526 C  C    . SER   C 1 79  ? 21.64500  -1.93800  41.56100  1.000 15.39371  ?  231 SER   B C    1 
ATOM   2527 O  O    . SER   C 1 79  ? 21.04400  -1.19200  42.34400  1.000 15.10639  ?  231 SER   B O    1 
ATOM   2528 C  CB   . SER   C 1 79  ? 21.96900  -1.30700  39.14900  1.000 16.86383  ?  231 SER   B CB   1 
ATOM   2529 O  OG   . SER   C 1 79  ? 20.86100  -0.42800  39.14100  1.000 18.74316  ?  231 SER   B OG   1 
ATOM   2530 N  N    . TYR   C 1 80  ? 21.48500  -3.26300  41.57000  1.000 17.07968  ?  232 TYR   B N    1 
ATOM   2531 C  CA   . TYR   C 1 80  ? 20.71000  -3.93800  42.60600  1.000 16.00097  ?  232 TYR   B CA   1 
ATOM   2532 C  C    . TYR   C 1 80  ? 21.26100  -3.64000  43.99700  1.000 24.24496  ?  232 TYR   B C    1 
ATOM   2533 O  O    . TYR   C 1 80  ? 20.49600  -3.40200  44.94100  1.000 14.40486  ?  232 TYR   B O    1 
ATOM   2534 C  CB   . TYR   C 1 80  ? 20.71800  -5.44100  42.31900  1.000 18.01076  ?  232 TYR   B CB   1 
ATOM   2535 C  CG   . TYR   C 1 80  ? 20.04700  -6.32400  43.34100  1.000 17.73234  ?  232 TYR   B CG   1 
ATOM   2536 C  CD1  . TYR   C 1 80  ? 18.67600  -6.53900  43.31200  1.000 24.86440  ?  232 TYR   B CD1  1 
ATOM   2537 C  CD2  . TYR   C 1 80  ? 20.79400  -6.97000  44.32300  1.000 26.08302  ?  232 TYR   B CD2  1 
ATOM   2538 C  CE1  . TYR   C 1 80  ? 18.06500  -7.35800  44.24200  1.000 26.52854  ?  232 TYR   B CE1  1 
ATOM   2539 C  CE2  . TYR   C 1 80  ? 20.18900  -7.79200  45.25500  1.000 24.02334  ?  232 TYR   B CE2  1 
ATOM   2540 C  CZ   . TYR   C 1 80  ? 18.82600  -7.98100  45.20900  1.000 23.63720  ?  232 TYR   B CZ   1 
ATOM   2541 O  OH   . TYR   C 1 80  ? 18.21500  -8.79900  46.13700  1.000 28.97792  ?  232 TYR   B OH   1 
ATOM   2542 N  N    . SER   C 1 81  ? 22.58900  -3.63900  44.13700  1.000 17.73910  ?  233 SER   B N    1 
ATOM   2543 C  CA   . SER   C 1 81  ? 23.21100  -3.39800  45.43600  1.000 18.59652  ?  233 SER   B CA   1 
ATOM   2544 C  C    . SER   C 1 81  ? 22.94900  -1.97900  45.92100  1.000 16.10352  ?  233 SER   B C    1 
ATOM   2545 O  O    . SER   C 1 81  ? 22.72400  -1.75800  47.11700  1.000 13.71149  ?  233 SER   B O    1 
ATOM   2546 C  CB   . SER   C 1 81  ? 24.71600  -3.64800  45.34700  1.000 20.81784  ?  233 SER   B CB   1 
ATOM   2547 O  OG   . SER   C 1 81  ? 24.98500  -4.98500  44.97200  1.000 31.92239  ?  233 SER   B OG   1 
ATOM   2548 N  N    . ILE   C 1 82  ? 22.99600  -1.00100  45.01000  1.000 11.52730  ?  234 ILE   B N    1 
ATOM   2549 C  CA   . ILE   C 1 82  ? 22.71000  0.38200   45.38400  1.000 14.61250  ?  234 ILE   B CA   1 
ATOM   2550 C  C    . ILE   C 1 82  ? 21.33100  0.47900   46.02100  1.000 15.81203  ?  234 ILE   B C    1 
ATOM   2551 O  O    . ILE   C 1 82  ? 21.15100  1.14500   47.04800  1.000 10.92784  ?  234 ILE   B O    1 
ATOM   2552 C  CB   . ILE   C 1 82  ? 22.83200  1.30900   44.15900  1.000 15.57149  ?  234 ILE   B CB   1 
ATOM   2553 C  CG1  . ILE   C 1 82  ? 24.28600  1.43100   43.71100  1.000 21.18976  ?  234 ILE   B CG1  1 
ATOM   2554 C  CG2  . ILE   C 1 82  ? 22.25300  2.68900   44.46400  1.000 18.32393  ?  234 ILE   B CG2  1 
ATOM   2555 C  CD1  . ILE   C 1 82  ? 24.44200  2.09000   42.34200  1.000 16.13435  ?  234 ILE   B CD1  1 
ATOM   2556 N  N    . GLN   C 1 83  ? 20.33900  -0.19100  45.42600  1.000 13.27994  ?  235 GLN   B N    1 
ATOM   2557 C  CA   . GLN   C 1 83  ? 18.99300  -0.18400  45.99300  1.000 16.58612  ?  235 GLN   B CA   1 
ATOM   2558 C  C    . GLN   C 1 83  ? 18.98900  -0.76000  47.40100  1.000 13.30014  ?  235 GLN   B C    1 
ATOM   2559 O  O    . GLN   C 1 83  ? 18.27600  -0.26600  48.28200  1.000 11.68360  ?  235 GLN   B O    1 
ATOM   2560 C  CB   . GLN   C 1 83  ? 18.04100  -0.97100  45.09600  1.000 18.29257  ?  235 GLN   B CB   1 
ATOM   2561 C  CG   . GLN   C 1 83  ? 17.94100  -0.43200  43.68700  1.000 17.43331  ?  235 GLN   B CG   1 
ATOM   2562 C  CD   . GLN   C 1 83  ? 16.88300  -1.13800  42.86800  1.000 39.91196  ?  235 GLN   B CD   1 
ATOM   2563 O  OE1  . GLN   C 1 83  ? 15.78100  -1.40300  43.35200  1.000 30.25645  ?  235 GLN   B OE1  1 
ATOM   2564 N  NE2  . GLN   C 1 83  ? 17.21200  -1.44700  41.61700  1.000 34.09778  ?  235 GLN   B NE2  1 
ATOM   2565 N  N    . LYS   C 1 84  ? 19.77300  -1.81500  47.62800  1.000 13.79739  ?  236 LYS   B N    1 
ATOM   2566 C  CA   . LYS   C 1 84  ? 19.86400  -2.39600  48.96100  1.000 13.74317  ?  236 LYS   B CA   1 
ATOM   2567 C  C    . LYS   C 1 84  ? 20.53400  -1.43500  49.93500  1.000 16.37974  ?  236 LYS   B C    1 
ATOM   2568 O  O    . LYS   C 1 84  ? 20.07300  -1.27700  51.07100  1.000 16.23282  ?  236 LYS   B O    1 
ATOM   2569 C  CB   . LYS   C 1 84  ? 20.61700  -3.72700  48.90400  1.000 18.05123  ?  236 LYS   B CB   1 
ATOM   2570 C  CG   . LYS   C 1 84  ? 19.92200  -4.79500  48.06300  1.000 17.75216  ?  236 LYS   B CG   1 
ATOM   2571 C  CD   . LYS   C 1 84  ? 18.44400  -4.88200  48.40600  1.000 23.82681  ?  236 LYS   B CD   1 
ATOM   2572 C  CE   . LYS   C 1 84  ? 17.83900  -6.20500  47.97500  1.000 33.81588  ?  236 LYS   B CE   1 
ATOM   2573 N  NZ   . LYS   C 1 84  ? 18.37800  -7.36300  48.74200  1.000 32.10958  ?  236 LYS   B NZ   1 
ATOM   2574 N  N    . VAL   C 1 85  ? 21.61200  -0.77300  49.50400  1.000 13.04306  ?  237 VAL   B N    1 
ATOM   2575 C  CA   . VAL   C 1 85  ? 22.30900  0.16700   50.38100  1.000 14.17421  ?  237 VAL   B CA   1 
ATOM   2576 C  C    . VAL   C 1 85  ? 21.39500  1.32700   50.76000  1.000 11.92993  ?  237 VAL   B C    1 
ATOM   2577 O  O    . VAL   C 1 85  ? 21.39000  1.78400   51.91100  1.000 10.33998  ?  237 VAL   B O    1 
ATOM   2578 C  CB   . VAL   C 1 85  ? 23.60600  0.66100   49.71400  1.000 11.43492  ?  237 VAL   B CB   1 
ATOM   2579 C  CG1  . VAL   C 1 85  ? 24.21100  1.81400   50.50700  1.000 12.42773  ?  237 VAL   B CG1  1 
ATOM   2580 C  CG2  . VAL   C 1 85  ? 24.60800  -0.49100  49.56900  1.000 12.48793  ?  237 VAL   B CG2  1 
ATOM   2581 N  N    . ILE   C 1 86  ? 20.61400  1.82700   49.80200  1.000 9.09958   ?  238 ILE   B N    1 
ATOM   2582 C  CA   . ILE   C 1 86  ? 19.65000  2.88200   50.11200  1.000 9.62903   ?  238 ILE   B CA   1 
ATOM   2583 C  C    . ILE   C 1 86  ? 18.66000  2.40200   51.16600  1.000 14.82777  ?  238 ILE   B C    1 
ATOM   2584 O  O    . ILE   C 1 86  ? 18.36400  3.11300   52.13400  1.000 14.11747  ?  238 ILE   B O    1 
ATOM   2585 C  CB   . ILE   C 1 86  ? 18.92500  3.35200   48.83900  1.000 15.96763  ?  238 ILE   B CB   1 
ATOM   2586 C  CG1  . ILE   C 1 86  ? 19.89900  4.02100   47.87200  1.000 15.32255  ?  238 ILE   B CG1  1 
ATOM   2587 C  CG2  . ILE   C 1 86  ? 17.79200  4.31000   49.20000  1.000 17.09470  ?  238 ILE   B CG2  1 
ATOM   2588 C  CD1  . ILE   C 1 86  ? 19.41700  3.99800   46.43800  1.000 18.41036  ?  238 ILE   B CD1  1 
ATOM   2589 N  N    . GLY   C 1 87  ? 18.13600  1.18300   50.99400  1.000 13.22266  ?  239 GLY   B N    1 
ATOM   2590 C  CA   . GLY   C 1 87  ? 17.18500  0.65400   51.96100  1.000 12.90951  ?  239 GLY   B CA   1 
ATOM   2591 C  C    . GLY   C 1 87  ? 17.77900  0.52900   53.35200  1.000 17.29573  ?  239 GLY   B C    1 
ATOM   2592 O  O    . GLY   C 1 87  ? 17.13300  0.86200   54.34900  1.000 15.10373  ?  239 GLY   B O    1 
ATOM   2593 N  N    . PHE   C 1 88  ? 19.02700  0.06500   53.43500  1.000 14.36025  ?  240 PHE   B N    1 
ATOM   2594 C  CA   . PHE   C 1 88  ? 19.70900  -0.02200  54.72300  1.000 12.65984  ?  240 PHE   B CA   1 
ATOM   2595 C  C    . PHE   C 1 88  ? 19.91400  1.36100   55.33300  1.000 15.30786  ?  240 PHE   B C    1 
ATOM   2596 O  O    . PHE   C 1 88  ? 19.60000  1.58400   56.50900  1.000 15.78224  ?  240 PHE   B O    1 
ATOM   2597 C  CB   . PHE   C 1 88  ? 21.04800  -0.74200  54.54800  1.000 11.94342  ?  240 PHE   B CB   1 
ATOM   2598 C  CG   . PHE   C 1 88  ? 21.90600  -0.74500  55.78000  1.000 13.88248  ?  240 PHE   B CG   1 
ATOM   2599 C  CD1  . PHE   C 1 88  ? 21.67000  -1.65000  56.80100  1.000 13.75940  ?  240 PHE   B CD1  1 
ATOM   2600 C  CD2  . PHE   C 1 88  ? 22.95900  0.14600   55.91000  1.000 8.27679   ?  240 PHE   B CD2  1 
ATOM   2601 C  CE1  . PHE   C 1 88  ? 22.46300  -1.65900  57.93900  1.000 15.78797  ?  240 PHE   B CE1  1 
ATOM   2602 C  CE2  . PHE   C 1 88  ? 23.76400  0.14000   57.04600  1.000 14.04580  ?  240 PHE   B CE2  1 
ATOM   2603 C  CZ   . PHE   C 1 88  ? 23.51700  -0.76400  58.05800  1.000 12.75008  ?  240 PHE   B CZ   1 
ATOM   2604 N  N    . ALA   C 1 89  ? 20.44200  2.30400   54.54000  1.000 12.39056  ?  241 ALA   B N    1 
ATOM   2605 C  CA   . ALA   C 1 89  ? 20.69100  3.65700   55.03400  1.000 11.55628  ?  241 ALA   B CA   1 
ATOM   2606 C  C    . ALA   C 1 89  ? 19.42500  4.29400   55.59300  1.000 13.16506  ?  241 ALA   B C    1 
ATOM   2607 O  O    . ALA   C 1 89  ? 19.47000  5.01100   56.60100  1.000 14.88577  ?  241 ALA   B O    1 
ATOM   2608 C  CB   . ALA   C 1 89  ? 21.26500  4.52600   53.91400  1.000 13.88618  ?  241 ALA   B CB   1 
ATOM   2609 N  N    . LYS   C 1 90  ? 18.28200  4.03300   54.95700  1.000 14.75500  ?  242 LYS   B N    1 
ATOM   2610 C  CA   . LYS   C 1 90  ? 17.02100  4.61600   55.40200  1.000 19.07458  ?  242 LYS   B CA   1 
ATOM   2611 C  C    . LYS   C 1 90  ? 16.65100  4.19500   56.81600  1.000 17.03577  ?  242 LYS   B C    1 
ATOM   2612 O  O    . LYS   C 1 90  ? 15.90100  4.91200   57.48700  1.000 16.43458  ?  242 LYS   B O    1 
ATOM   2613 C  CB   . LYS   C 1 90  ? 15.90100  4.23600   54.42800  1.000 15.88664  ?  242 LYS   B CB   1 
ATOM   2614 C  CG   . LYS   C 1 90  ? 15.94400  5.01900   53.12300  1.000 25.01580  ?  242 LYS   B CG   1 
ATOM   2615 C  CD   . LYS   C 1 90  ? 15.00000  4.44000   52.07800  1.000 23.84717  ?  242 LYS   B CD   1 
ATOM   2616 C  CE   . LYS   C 1 90  ? 13.54300  4.57000   52.50100  1.000 31.00600  ?  242 LYS   B CE   1 
ATOM   2617 N  NZ   . LYS   C 1 90  ? 12.62700  4.05300   51.44300  1.000 27.39699  ?  242 LYS   B NZ   1 
ATOM   2618 N  N    A MET   C 1 91  ? 17.16100  3.06600   57.29500  0.610 12.80193  ?  243 MET   B N    1 
ATOM   2619 N  N    B MET   C 1 91  ? 17.16600  3.05700   57.28000  0.390 12.36322  ?  243 MET   B N    1 
ATOM   2620 C  CA   A MET   C 1 91  ? 16.82700  2.58600   58.62700  0.610 20.18604  ?  243 MET   B CA   1 
ATOM   2621 C  CA   B MET   C 1 91  ? 16.86700  2.52700   58.60300  0.390 20.09172  ?  243 MET   B CA   1 
ATOM   2622 C  C    A MET   C 1 91  ? 17.90100  2.89100   59.66400  0.610 15.30617  ?  243 MET   B C    1 
ATOM   2623 C  C    B MET   C 1 91  ? 17.86600  2.95800   59.66600  0.390 15.29626  ?  243 MET   B C    1 
ATOM   2624 O  O    A MET   C 1 91  ? 17.73600  2.51900   60.82900  0.610 15.81157  ?  243 MET   B O    1 
ATOM   2625 O  O    B MET   C 1 91  ? 17.61500  2.72600   60.85400  0.390 15.61136  ?  243 MET   B O    1 
ATOM   2626 C  CB   A MET   C 1 91  ? 16.54500  1.08200   58.58500  0.610 18.12455  ?  243 MET   B CB   1 
ATOM   2627 C  CB   B MET   C 1 91  ? 16.82500  1.00000   58.56100  0.390 17.53982  ?  243 MET   B CB   1 
ATOM   2628 C  CG   A MET   C 1 91  ? 15.34300  0.73200   57.72100  0.610 22.97227  ?  243 MET   B CG   1 
ATOM   2629 C  CG   B MET   C 1 91  ? 15.89500  0.42900   57.51400  0.390 21.43339  ?  243 MET   B CG   1 
ATOM   2630 S  SD   A MET   C 1 91  ? 15.02700  -1.03600  57.62000  0.610 18.79920  ?  243 MET   B SD   1 
ATOM   2631 S  SD   B MET   C 1 91  ? 14.21000  0.99300   57.77700  0.390 25.46608  ?  243 MET   B SD   1 
ATOM   2632 C  CE   A MET   C 1 91  ? 15.90800  -1.46900  56.12600  0.610 15.40983  ?  243 MET   B CE   1 
ATOM   2633 C  CE   B MET   C 1 91  ? 13.77900  0.05400   59.24100  0.390 20.08939  ?  243 MET   B CE   1 
ATOM   2634 N  N    . ILE   C 1 92  ? 18.99000  3.55000   59.27700  1.000 13.63651  ?  244 ILE   B N    1 
ATOM   2635 C  CA   . ILE   C 1 92  ? 19.97200  4.04000   60.24400  1.000 12.41644  ?  244 ILE   B CA   1 
ATOM   2636 C  C    . ILE   C 1 92  ? 19.28500  5.10700   61.08600  1.000 11.53901  ?  244 ILE   B C    1 
ATOM   2637 O  O    . ILE   C 1 92  ? 18.75200  6.07700   60.52700  1.000 15.78293  ?  244 ILE   B O    1 
ATOM   2638 C  CB   . ILE   C 1 92  ? 21.22400  4.61100   59.56100  1.000 11.35636  ?  244 ILE   B CB   1 
ATOM   2639 C  CG1  . ILE   C 1 92  ? 21.94900  3.53100   58.75300  1.000 11.33747  ?  244 ILE   B CG1  1 
ATOM   2640 C  CG2  . ILE   C 1 92  ? 22.15000  5.24700   60.60400  1.000 14.39302  ?  244 ILE   B CG2  1 
ATOM   2641 C  CD1  . ILE   C 1 92  ? 23.09900  4.08500   57.90800  1.000 9.61740   ?  244 ILE   B CD1  1 
ATOM   2642 N  N    . PRO   C 1 93  ? 19.24900  4.96300   62.41800  1.000 16.11963  ?  245 PRO   B N    1 
ATOM   2643 C  CA   . PRO   C 1 93  ? 18.57900  5.97200   63.25200  1.000 24.19232  ?  245 PRO   B CA   1 
ATOM   2644 C  C    . PRO   C 1 93  ? 19.10700  7.37400   62.99700  1.000 21.86241  ?  245 PRO   B C    1 
ATOM   2645 O  O    . PRO   C 1 93  ? 20.31300  7.62200   63.09200  1.000 18.23655  ?  245 PRO   B O    1 
ATOM   2646 C  CB   . PRO   C 1 93  ? 18.88600  5.50900   64.68200  1.000 22.31756  ?  245 PRO   B CB   1 
ATOM   2647 C  CG   . PRO   C 1 93  ? 19.11300  4.04500   64.55800  1.000 23.91505  ?  245 PRO   B CG   1 
ATOM   2648 C  CD   . PRO   C 1 93  ? 19.76100  3.83400   63.21400  1.000 16.51894  ?  245 PRO   B CD   1 
ATOM   2649 N  N    . GLY   C 1 94  ? 18.20800  8.28900   62.64100  1.000 15.89845  ?  246 GLY   B N    1 
ATOM   2650 C  CA   . GLY   C 1 94  ? 18.55500  9.66500   62.37300  1.000 24.32389  ?  246 GLY   B CA   1 
ATOM   2651 C  C    . GLY   C 1 94  ? 18.77600  10.00100  60.91000  1.000 16.95763  ?  246 GLY   B C    1 
ATOM   2652 O  O    . GLY   C 1 94  ? 18.66500  11.17400  60.54200  1.000 16.80958  ?  246 GLY   B O    1 
ATOM   2653 N  N    . PHE   C 1 95  ? 19.07700  9.00800   60.06400  1.000 17.03538  ?  247 PHE   B N    1 
ATOM   2654 C  CA   . PHE   C 1 95  ? 19.45100  9.30300   58.68300  1.000 16.55448  ?  247 PHE   B CA   1 
ATOM   2655 C  C    . PHE   C 1 95  ? 18.31800  9.99100   57.93800  1.000 19.41768  ?  247 PHE   B C    1 
ATOM   2656 O  O    . PHE   C 1 95  ? 18.54100  10.97500  57.22800  1.000 14.14932  ?  247 PHE   B O    1 
ATOM   2657 C  CB   . PHE   C 1 95  ? 19.87300  8.02700   57.95200  1.000 16.42565  ?  247 PHE   B CB   1 
ATOM   2658 C  CG   . PHE   C 1 95  ? 20.27600  8.25400   56.51800  1.000 18.06059  ?  247 PHE   B CG   1 
ATOM   2659 C  CD1  . PHE   C 1 95  ? 21.56600  8.65400   56.19800  1.000 16.28871  ?  247 PHE   B CD1  1 
ATOM   2660 C  CD2  . PHE   C 1 95  ? 19.36400  8.07100   55.49000  1.000 12.21128  ?  247 PHE   B CD2  1 
ATOM   2661 C  CE1  . PHE   C 1 95  ? 21.93900  8.86600   54.87500  1.000 17.15038  ?  247 PHE   B CE1  1 
ATOM   2662 C  CE2  . PHE   C 1 95  ? 19.73000  8.28000   54.16600  1.000 15.76190  ?  247 PHE   B CE2  1 
ATOM   2663 C  CZ   . PHE   C 1 95  ? 21.02100  8.67900   53.85900  1.000 13.72748  ?  247 PHE   B CZ   1 
ATOM   2664 N  N    . ARG   C 1 96  ? 17.09000  9.48900   58.08500  1.000 16.72752  ?  248 ARG   B N    1 
ATOM   2665 C  CA   . ARG   C 1 96  ? 15.97300  10.10600  57.38000  1.000 28.38792  ?  248 ARG   B CA   1 
ATOM   2666 C  C    . ARG   C 1 96  ? 15.57700  11.45400  57.96600  1.000 19.83029  ?  248 ARG   B C    1 
ATOM   2667 O  O    . ARG   C 1 96  ? 14.78500  12.16900  57.34500  1.000 31.59836  ?  248 ARG   B O    1 
ATOM   2668 C  CB   . ARG   C 1 96  ? 14.77000  9.16500   57.37000  1.000 23.57273  ?  248 ARG   B CB   1 
ATOM   2669 C  CG   . ARG   C 1 96  ? 14.94000  8.00600   56.40700  1.000 30.14893  ?  248 ARG   B CG   1 
ATOM   2670 C  CD   . ARG   C 1 96  ? 13.61800  7.32400   56.12700  1.000 41.61614  ?  248 ARG   B CD   1 
ATOM   2671 N  NE   . ARG   C 1 96  ? 12.89800  7.97200   55.03600  1.000 46.80269  ?  248 ARG   B NE   1 
ATOM   2672 C  CZ   . ARG   C 1 96  ? 11.72100  7.56300   54.57800  1.000 51.49944  ?  248 ARG   B CZ   1 
ATOM   2673 N  NH1  . ARG   C 1 96  ? 11.13100  6.50500   55.11800  1.000 47.84816  ?  248 ARG   B NH1  1 
ATOM   2674 N  NH2  . ARG   C 1 96  ? 11.13200  8.21100   53.58200  1.000 46.59275  ?  248 ARG   B NH2  1 
ATOM   2675 N  N    . ASP   C 1 97  ? 16.10900  11.81700  59.12900  1.000 26.83292  ?  249 ASP   B N    1 
ATOM   2676 C  CA   . ASP   C 1 97  ? 15.86900  13.13300  59.70200  1.000 25.23906  ?  249 ASP   B CA   1 
ATOM   2677 C  C    . ASP   C 1 97  ? 16.80800  14.19600  59.14700  1.000 36.20345  ?  249 ASP   B C    1 
ATOM   2678 O  O    . ASP   C 1 97  ? 16.67000  15.36800  59.51300  1.000 34.54494  ?  249 ASP   B O    1 
ATOM   2679 C  CB   . ASP   C 1 97  ? 15.99000  13.06800  61.22400  1.000 28.72715  ?  249 ASP   B CB   1 
ATOM   2680 C  CG   . ASP   C 1 97  ? 14.97600  12.12900  61.84600  1.000 25.40963  ?  249 ASP   B CG   1 
ATOM   2681 O  OD1  . ASP   C 1 97  ? 13.94400  11.85700  61.19500  1.000 25.42519  ?  249 ASP   B OD1  1 
ATOM   2682 O  OD2  . ASP   C 1 97  ? 15.20800  11.66900  62.98200  1.000 26.44302  ?  249 ASP   B OD2  1 
ATOM   2683 N  N    . LEU   C 1 98  ? 17.75500  13.82000  58.29100  1.000 20.78196  ?  250 LEU   B N    1 
ATOM   2684 C  CA   . LEU   C 1 98  ? 18.57400  14.79400  57.58800  1.000 22.29818  ?  250 LEU   B CA   1 
ATOM   2685 C  C    . LEU   C 1 98  ? 17.81000  15.34500  56.38900  1.000 20.52267  ?  250 LEU   B C    1 
ATOM   2686 O  O    . LEU   C 1 98  ? 16.82700  14.75900  55.92800  1.000 21.08957  ?  250 LEU   B O    1 
ATOM   2687 C  CB   . LEU   C 1 98  ? 19.88500  14.16200  57.12200  1.000 16.95216  ?  250 LEU   B CB   1 
ATOM   2688 C  CG   . LEU   C 1 98  ? 20.75200  13.48800  58.18900  1.000 16.31269  ?  250 LEU   B CG   1 
ATOM   2689 C  CD1  . LEU   C 1 98  ? 21.88300  12.69400  57.54700  1.000 16.21638  ?  250 LEU   B CD1  1 
ATOM   2690 C  CD2  . LEU   C 1 98  ? 21.30600  14.51900  59.15500  1.000 15.05079  ?  250 LEU   B CD2  1 
ATOM   2691 N  N    . THR   C 1 99  ? 18.27000  16.48600  55.88000  1.000 14.86609  ?  251 THR   B N    1 
ATOM   2692 C  CA   . THR   C 1 99  ? 17.68600  17.00000  54.65000  1.000 23.61271  ?  251 THR   B CA   1 
ATOM   2693 C  C    . THR   C 1 99  ? 17.91000  16.00300  53.51800  1.000 26.60730  ?  251 THR   B C    1 
ATOM   2694 O  O    . THR   C 1 99  ? 18.83600  15.19000  53.54800  1.000 18.87741  ?  251 THR   B O    1 
ATOM   2695 C  CB   . THR   C 1 99  ? 18.28500  18.35600  54.27000  1.000 22.98015  ?  251 THR   B CB   1 
ATOM   2696 O  OG1  . THR   C 1 99  ? 19.66400  18.19400  53.91500  1.000 21.99482  ?  251 THR   B OG1  1 
ATOM   2697 C  CG2  . THR   C 1 99  ? 18.16900  19.33700  55.42700  1.000 24.51628  ?  251 THR   B CG2  1 
ATOM   2698 N  N    A SER   C 1 100 ? 17.03400  16.07200  52.51200  0.580 18.56912  ?  252 SER   B N    1 
ATOM   2699 N  N    B SER   C 1 100 ? 17.03900  16.06800  52.50900  0.420 18.64713  ?  252 SER   B N    1 
ATOM   2700 C  CA   A SER   C 1 100 ? 17.16000  15.19100  51.35400  0.580 21.74726  ?  252 SER   B CA   1 
ATOM   2701 C  CA   B SER   C 1 100 ? 17.18000  15.16800  51.36900  0.420 21.73135  ?  252 SER   B CA   1 
ATOM   2702 C  C    A SER   C 1 100 ? 18.48000  15.41700  50.62900  0.580 18.81507  ?  252 SER   B C    1 
ATOM   2703 C  C    B SER   C 1 100 ? 18.48200  15.41500  50.61900  0.420 18.85058  ?  252 SER   B C    1 
ATOM   2704 O  O    A SER   C 1 100 ? 19.09100  14.46600  50.12800  0.580 18.40862  ?  252 SER   B O    1 
ATOM   2705 O  O    B SER   C 1 100 ? 19.08000  14.47200  50.09000  0.420 18.43377  ?  252 SER   B O    1 
ATOM   2706 C  CB   A SER   C 1 100 ? 15.98400  15.40800  50.40300  0.580 22.38854  ?  252 SER   B CB   1 
ATOM   2707 C  CB   B SER   C 1 100 ? 15.98800  15.31900  50.42600  0.420 22.42200  ?  252 SER   B CB   1 
ATOM   2708 O  OG   A SER   C 1 100 ? 14.75200  15.14900  51.05200  0.580 25.89485  ?  252 SER   B OG   1 
ATOM   2709 O  OG   B SER   C 1 100 ? 15.68800  16.68400  50.20000  0.420 21.63870  ?  252 SER   B OG   1 
ATOM   2710 N  N    . ASP   C 1 101 ? 18.93500  16.67100  50.56600  1.000 20.37290  ?  253 ASP   B N    1 
ATOM   2711 C  CA   . ASP   C 1 101 ? 20.21500  16.97600  49.93200  1.000 20.75198  ?  253 ASP   B CA   1 
ATOM   2712 C  C    . ASP   C 1 101 ? 21.35900  16.23200  50.61200  1.000 18.62185  ?  253 ASP   B C    1 
ATOM   2713 O  O    . ASP   C 1 101 ? 22.21700  15.64200  49.94400  1.000 21.87468  ?  253 ASP   B O    1 
ATOM   2714 C  CB   . ASP   C 1 101 ? 20.47400  18.48100  49.97300  1.000 31.58810  ?  253 ASP   B CB   1 
ATOM   2715 C  CG   . ASP   C 1 101 ? 19.89500  19.21000  48.78100  1.000 44.99869  ?  253 ASP   B CG   1 
ATOM   2716 O  OD1  . ASP   C 1 101 ? 19.20300  18.56700  47.96300  1.000 33.96818  ?  253 ASP   B OD1  1 
ATOM   2717 O  OD2  . ASP   C 1 101 ? 20.13700  20.43000  48.66500  1.000 42.00851  ?  253 ASP   B OD2  1 
ATOM   2718 N  N    . ASP   C 1 102 ? 21.39400  16.25900  51.94800  1.000 17.82282  ?  254 ASP   B N    1 
ATOM   2719 C  CA   . ASP   C 1 102 ? 22.45700  15.55900  52.66300  1.000 18.70827  ?  254 ASP   B CA   1 
ATOM   2720 C  C    . ASP   C 1 102 ? 22.31100  14.04700  52.53800  1.000 19.35834  ?  254 ASP   B C    1 
ATOM   2721 O  O    . ASP   C 1 102 ? 23.31100  13.33000  52.40000  1.000 14.33951  ?  254 ASP   B O    1 
ATOM   2722 C  CB   . ASP   C 1 102 ? 22.48000  15.98100  54.13000  1.000 20.37602  ?  254 ASP   B CB   1 
ATOM   2723 C  CG   . ASP   C 1 102 ? 23.18600  17.30700  54.33600  1.000 28.83087  ?  254 ASP   B CG   1 
ATOM   2724 O  OD1  . ASP   C 1 102 ? 22.97500  17.94100  55.38800  1.000 24.69709  ?  254 ASP   B OD1  1 
ATOM   2725 O  OD2  . ASP   C 1 102 ? 23.94700  17.71600  53.43200  1.000 28.98656  ?  254 ASP   B OD2  1 
ATOM   2726 N  N    . GLN   C 1 103 ? 21.07600  13.54200  52.58000  1.000 11.83810  ?  255 GLN   B N    1 
ATOM   2727 C  CA   . GLN   C 1 103 ? 20.87100  12.11600  52.34700  1.000 18.76429  ?  255 GLN   B CA   1 
ATOM   2728 C  C    . GLN   C 1 103 ? 21.42100  11.70300  50.98900  1.000 14.59928  ?  255 GLN   B C    1 
ATOM   2729 O  O    . GLN   C 1 103 ? 22.08700  10.66600  50.86800  1.000 12.52884  ?  255 GLN   B O    1 
ATOM   2730 C  CB   . GLN   C 1 103 ? 19.38700  11.76700  52.45200  1.000 15.46149  ?  255 GLN   B CB   1 
ATOM   2731 C  CG   . GLN   C 1 103 ? 18.80200  11.93500  53.84300  1.000 17.83359  ?  255 GLN   B CG   1 
ATOM   2732 C  CD   . GLN   C 1 103 ? 17.32600  11.58800  53.89300  1.000 23.97310  ?  255 GLN   B CD   1 
ATOM   2733 O  OE1  . GLN   C 1 103 ? 16.53600  12.26300  54.55200  1.000 21.56342  ?  255 GLN   B OE1  1 
ATOM   2734 N  NE2  . GLN   C 1 103 ? 16.95100  10.52700  53.19500  1.000 19.56669  ?  255 GLN   B NE2  1 
ATOM   2735 N  N    . ILE   C 1 104 ? 21.17500  12.51900  49.96100  1.000 12.11462  ?  256 ILE   B N    1 
ATOM   2736 C  CA   . ILE   C 1 104 ? 21.65800  12.20800  48.61900  1.000 11.96231  ?  256 ILE   B CA   1 
ATOM   2737 C  C    . ILE   C 1 104 ? 23.18000  12.25200  48.57400  1.000 13.39085  ?  256 ILE   B C    1 
ATOM   2738 O  O    . ILE   C 1 104 ? 23.82500  11.35300  48.02400  1.000 15.26332  ?  256 ILE   B O    1 
ATOM   2739 C  CB   . ILE   C 1 104 ? 21.03400  13.17200  47.59200  1.000 17.67165  ?  256 ILE   B CB   1 
ATOM   2740 C  CG1  . ILE   C 1 104 ? 19.55800  12.83900  47.37700  1.000 21.38248  ?  256 ILE   B CG1  1 
ATOM   2741 C  CG2  . ILE   C 1 104 ? 21.78400  13.11700  46.27000  1.000 15.63875  ?  256 ILE   B CG2  1 
ATOM   2742 C  CD1  . ILE   C 1 104 ? 18.81700  13.88300  46.56100  1.000 25.18630  ?  256 ILE   B CD1  1 
ATOM   2743 N  N    . VAL   C 1 105 ? 23.77500  13.29700  49.15600  1.000 15.33917  ?  257 VAL   B N    1 
ATOM   2744 C  CA   . VAL   C 1 105 ? 25.22900  13.44900  49.13000  1.000 20.75024  ?  257 VAL   B CA   1 
ATOM   2745 C  C    . VAL   C 1 105 ? 25.90200  12.28300  49.84700  1.000 11.96335  ?  257 VAL   B C    1 
ATOM   2746 O  O    . VAL   C 1 105 ? 26.87800  11.70600  49.35200  1.000 15.31461  ?  257 VAL   B O    1 
ATOM   2747 C  CB   . VAL   C 1 105 ? 25.63900  14.79900  49.75000  1.000 22.74347  ?  257 VAL   B CB   1 
ATOM   2748 C  CG1  . VAL   C 1 105 ? 27.11500  14.79200  50.11300  1.000 25.68360  ?  257 VAL   B CG1  1 
ATOM   2749 C  CG2  . VAL   C 1 105 ? 25.32500  15.94000  48.79300  1.000 25.11006  ?  257 VAL   B CG2  1 
ATOM   2750 N  N    . LEU   C 1 106 ? 25.38800  11.91900  51.02400  1.000 11.78581  ?  258 LEU   B N    1 
ATOM   2751 C  CA   . LEU   C 1 106 ? 25.98700  10.82800  51.78500  1.000 15.77067  ?  258 LEU   B CA   1 
ATOM   2752 C  C    . LEU   C 1 106 ? 25.90900  9.50800   51.02400  1.000 14.46349  ?  258 LEU   B C    1 
ATOM   2753 O  O    . LEU   C 1 106 ? 26.86200  8.72200   51.03200  1.000 13.87191  ?  258 LEU   B O    1 
ATOM   2754 C  CB   . LEU   C 1 106 ? 25.30400  10.70200  53.14900  1.000 12.71283  ?  258 LEU   B CB   1 
ATOM   2755 C  CG   . LEU   C 1 106 ? 25.52400  11.84700  54.13700  1.000 12.56719  ?  258 LEU   B CG   1 
ATOM   2756 C  CD1  . LEU   C 1 106 ? 24.64900  11.66600  55.37800  1.000 14.42050  ?  258 LEU   B CD1  1 
ATOM   2757 C  CD2  . LEU   C 1 106 ? 26.98900  11.94700  54.52500  1.000 13.45456  ?  258 LEU   B CD2  1 
ATOM   2758 N  N    . LEU   C 1 107 ? 24.78500  9.24700   50.35500  1.000 10.84927  ?  259 LEU   B N    1 
ATOM   2759 C  CA   . LEU   C 1 107 ? 24.63900  7.98600   49.63300  1.000 13.48349  ?  259 LEU   B CA   1 
ATOM   2760 C  C    . LEU   C 1 107 ? 25.48000  7.96000   48.35900  1.000 14.20761  ?  259 LEU   B C    1 
ATOM   2761 O  O    . LEU   C 1 107 ? 26.10000  6.93700   48.04400  1.000 14.87001  ?  259 LEU   B O    1 
ATOM   2762 C  CB   . LEU   C 1 107 ? 23.16300  7.73100   49.32100  1.000 13.74084  ?  259 LEU   B CB   1 
ATOM   2763 C  CG   . LEU   C 1 107 ? 22.38900  7.16100   50.51000  1.000 20.69875  ?  259 LEU   B CG   1 
ATOM   2764 C  CD1  . LEU   C 1 107 ? 20.89000  7.35200   50.34100  1.000 22.60268  ?  259 LEU   B CD1  1 
ATOM   2765 C  CD2  . LEU   C 1 107 ? 22.73400  5.68500   50.69600  1.000 21.31916  ?  259 LEU   B CD2  1 
ATOM   2766 N  N    A LYS   C 1 108 ? 25.51500  9.07100   47.61600  0.510 14.95139  ?  260 LYS   B N    1 
ATOM   2767 N  N    B LYS   C 1 108 ? 25.51000  9.07000   47.61300  0.490 14.95215  ?  260 LYS   B N    1 
ATOM   2768 C  CA   A LYS   C 1 108 ? 26.32400  9.12200   46.39900  0.510 16.16780  ?  260 LYS   B CA   1 
ATOM   2769 C  CA   B LYS   C 1 108 ? 26.32800  9.12700   46.40400  0.490 16.17333  ?  260 LYS   B CA   1 
ATOM   2770 C  C    A LYS   C 1 108 ? 27.79600  8.87500   46.70000  0.510 16.92938  ?  260 LYS   B C    1 
ATOM   2771 C  C    B LYS   C 1 108 ? 27.79900  8.89300   46.72200  0.490 16.94937  ?  260 LYS   B C    1 
ATOM   2772 O  O    A LYS   C 1 108 ? 28.48300  8.17800   45.94400  0.510 15.86609  ?  260 LYS   B O    1 
ATOM   2773 O  O    B LYS   C 1 108 ? 28.50600  8.21900   45.96300  0.490 15.87415  ?  260 LYS   B O    1 
ATOM   2774 C  CB   A LYS   C 1 108 ? 26.15400  10.47200  45.70000  0.510 20.44144  ?  260 LYS   B CB   1 
ATOM   2775 C  CB   B LYS   C 1 108 ? 26.15300  10.47700  45.70500  0.490 20.44093  ?  260 LYS   B CB   1 
ATOM   2776 C  CG   A LYS   C 1 108 ? 24.83100  10.65600  44.98800  0.510 22.24135  ?  260 LYS   B CG   1 
ATOM   2777 C  CG   B LYS   C 1 108 ? 24.85700  10.63300  44.93300  0.490 22.23142  ?  260 LYS   B CG   1 
ATOM   2778 C  CD   A LYS   C 1 108 ? 24.82500  11.95600  44.19900  0.510 21.68966  ?  260 LYS   B CD   1 
ATOM   2779 C  CD   B LYS   C 1 108 ? 24.77600  12.00500  44.28000  0.490 21.71096  ?  260 LYS   B CD   1 
ATOM   2780 C  CE   A LYS   C 1 108 ? 25.71600  11.86300  42.96800  0.510 27.46718  ?  260 LYS   B CE   1 
ATOM   2781 C  CE   B LYS   C 1 108 ? 25.88100  12.20200  43.25200  0.490 27.45258  ?  260 LYS   B CE   1 
ATOM   2782 N  NZ   A LYS   C 1 108 ? 25.73600  13.13600  42.19500  0.510 29.85767  ?  260 LYS   B NZ   1 
ATOM   2783 N  NZ   B LYS   C 1 108 ? 25.54800  11.56600  41.94600  0.490 22.83204  ?  260 LYS   B NZ   1 
ATOM   2784 N  N    A SER   C 1 109 ? 28.29800  9.43800   47.80200  0.510 17.48634  ?  261 SER   B N    1 
ATOM   2785 N  N    B SER   C 1 109 ? 28.27700  9.43900   47.84200  0.490 17.44344  ?  261 SER   B N    1 
ATOM   2786 C  CA   A SER   C 1 109 ? 29.70700  9.30500   48.14200  0.510 17.15468  ?  261 SER   B CA   1 
ATOM   2787 C  CA   B SER   C 1 109 ? 29.68900  9.32800   48.18100  0.490 17.17289  ?  261 SER   B CA   1 
ATOM   2788 C  C    A SER   C 1 109 ? 30.04500  7.97100   48.79500  0.510 17.18518  ?  261 SER   B C    1 
ATOM   2789 C  C    B SER   C 1 109 ? 30.03700  7.97400   48.78700  0.490 17.17601  ?  261 SER   B C    1 
ATOM   2790 O  O    A SER   C 1 109 ? 31.19600  7.53200   48.71000  0.510 18.70460  ?  261 SER   B O    1 
ATOM   2791 O  O    B SER   C 1 109 ? 31.18000  7.52000   48.66100  0.490 18.71507  ?  261 SER   B O    1 
ATOM   2792 C  CB   A SER   C 1 109 ? 30.13100  10.44300  49.07200  0.510 20.61346  ?  261 SER   B CB   1 
ATOM   2793 C  CB   B SER   C 1 109 ? 30.08400  10.44400  49.14800  0.490 20.61599  ?  261 SER   B CB   1 
ATOM   2794 O  OG   A SER   C 1 109 ? 29.26800  10.53000  50.19300  0.510 19.23140  ?  261 SER   B OG   1 
ATOM   2795 O  OG   B SER   C 1 109 ? 29.52900  11.68500  48.75000  0.490 24.44539  ?  261 SER   B OG   1 
ATOM   2796 N  N    . SER   C 1 110 ? 29.08200  7.31300   49.43600  1.000 13.11310  ?  262 SER   B N    1 
ATOM   2797 C  CA   . SER   C 1 110 ? 29.36000  6.09400   50.18300  1.000 13.46399  ?  262 SER   B CA   1 
ATOM   2798 C  C    . SER   C 1 110 ? 28.95800  4.80900   49.46900  1.000 16.61118  ?  262 SER   B C    1 
ATOM   2799 O  O    . SER   C 1 110 ? 29.41700  3.73600   49.87900  1.000 17.27671  ?  262 SER   B O    1 
ATOM   2800 C  CB   . SER   C 1 110 ? 28.66200  6.17300   51.54900  1.000 18.54408  ?  262 SER   B CB   1 
ATOM   2801 O  OG   . SER   C 1 110 ? 27.34000  5.66900   51.48400  1.000 19.83792  ?  262 SER   B OG   1 
ATOM   2802 N  N    . ALA   C 1 111 ? 28.14800  4.88600   48.40600  1.000 15.21816  ?  263 ALA   B N    1 
ATOM   2803 C  CA   . ALA   C 1 111 ? 27.56200  3.68100   47.81900  1.000 11.89007  ?  263 ALA   B CA   1 
ATOM   2804 C  C    . ALA   C 1 111 ? 28.62800  2.66300   47.43800  1.000 17.36955  ?  263 ALA   B C    1 
ATOM   2805 O  O    . ALA   C 1 111 ? 28.51500  1.47400   47.76500  1.000 13.54194  ?  263 ALA   B O    1 
ATOM   2806 C  CB   . ALA   C 1 111 ? 26.71900  4.05500   46.59900  1.000 13.63618  ?  263 ALA   B CB   1 
ATOM   2807 N  N    . ILE   C 1 112 ? 29.67800  3.11300   46.74700  1.000 14.27695  ?  264 ILE   B N    1 
ATOM   2808 C  CA   . ILE   C 1 112 ? 30.70400  2.18500   46.27700  1.000 15.22852  ?  264 ILE   B CA   1 
ATOM   2809 C  C    . ILE   C 1 112 ? 31.44300  1.55900   47.45500  1.000 14.33621  ?  264 ILE   B C    1 
ATOM   2810 O  O    . ILE   C 1 112 ? 31.82200  0.38200   47.41300  1.000 15.21778  ?  264 ILE   B O    1 
ATOM   2811 C  CB   . ILE   C 1 112 ? 31.66600  2.90000   45.30300  1.000 21.77803  ?  264 ILE   B CB   1 
ATOM   2812 C  CG1  . ILE   C 1 112 ? 32.57700  1.88500   44.62400  1.000 26.87274  ?  264 ILE   B CG1  1 
ATOM   2813 C  CG2  . ILE   C 1 112 ? 32.47400  3.97700   46.00000  1.000 24.16696  ?  264 ILE   B CG2  1 
ATOM   2814 C  CD1  . ILE   C 1 112 ? 31.80000  0.85500   43.86300  1.000 31.86612  ?  264 ILE   B CD1  1 
ATOM   2815 N  N    . GLU   C 1 113 ? 31.63600  2.32500   48.53300  1.000 13.85207  ?  265 GLU   B N    1 
ATOM   2816 C  CA   . GLU   C 1 113 ? 32.32600  1.80400   49.71000  1.000 16.55464  ?  265 GLU   B CA   1 
ATOM   2817 C  C    . GLU   C 1 113 ? 31.48100  0.77200   50.44400  1.000 18.01334  ?  265 GLU   B C    1 
ATOM   2818 O  O    . GLU   C 1 113 ? 32.00300  -0.24700  50.91100  1.000 15.61131  ?  265 GLU   B O    1 
ATOM   2819 C  CB   . GLU   C 1 113 ? 32.68500  2.94900   50.65200  1.000 15.98791  ?  265 GLU   B CB   1 
ATOM   2820 C  CG   . GLU   C 1 113 ? 33.66800  3.95200   50.07600  1.000 17.31263  ?  265 GLU   B CG   1 
ATOM   2821 C  CD   . GLU   C 1 113 ? 33.94100  5.08100   51.04200  1.000 16.53787  ?  265 GLU   B CD   1 
ATOM   2822 O  OE1  . GLU   C 1 113 ? 33.64500  4.90800   52.24200  1.000 21.03891  ?  265 GLU   B OE1  1 
ATOM   2823 O  OE2  . GLU   C 1 113 ? 34.43300  6.14300   50.61000  1.000 20.75771  ?  265 GLU   B OE2  1 
ATOM   2824 N  N    . VAL   C 1 114 ? 30.17700  1.02700   50.57800  1.000 13.01641  ?  266 VAL   B N    1 
ATOM   2825 C  CA   . VAL   C 1 114 ? 29.31200  0.06700   51.25300  1.000 11.52605  ?  266 VAL   B CA   1 
ATOM   2826 C  C    . VAL   C 1 114 ? 29.15300  -1.18900  50.41200  1.000 15.90787  ?  266 VAL   B C    1 
ATOM   2827 O  O    . VAL   C 1 114 ? 29.03700  -2.29500  50.95300  1.000 15.11179  ?  266 VAL   B O    1 
ATOM   2828 C  CB   . VAL   C 1 114 ? 27.95200  0.70800   51.57700  1.000 13.01796  ?  266 VAL   B CB   1 
ATOM   2829 C  CG1  . VAL   C 1 114 ? 27.05400  -0.28100  52.32200  1.000 16.12976  ?  266 VAL   B CG1  1 
ATOM   2830 C  CG2  . VAL   C 1 114 ? 28.15800  1.97400   52.38500  1.000 13.59430  ?  266 VAL   B CG2  1 
ATOM   2831 N  N    . ILE   C 1 115 ? 29.15700  -1.04900  49.08400  1.000 12.64315  ?  267 ILE   B N    1 
ATOM   2832 C  CA   . ILE   C 1 115 ? 29.09300  -2.22500  48.22000  1.000 11.98562  ?  267 ILE   B CA   1 
ATOM   2833 C  C    . ILE   C 1 115 ? 30.30900  -3.11500  48.44800  1.000 18.22464  ?  267 ILE   B C    1 
ATOM   2834 O  O    . ILE   C 1 115 ? 30.19000  -4.34200  48.56300  1.000 16.44149  ?  267 ILE   B O    1 
ATOM   2835 C  CB   . ILE   C 1 115 ? 28.95800  -1.79800  46.74600  1.000 16.96748  ?  267 ILE   B CB   1 
ATOM   2836 C  CG1  . ILE   C 1 115 ? 27.51000  -1.41200  46.44500  1.000 16.02007  ?  267 ILE   B CG1  1 
ATOM   2837 C  CG2  . ILE   C 1 115 ? 29.42200  -2.90900  45.82100  1.000 19.21736  ?  267 ILE   B CG2  1 
ATOM   2838 C  CD1  . ILE   C 1 115 ? 27.34400  -0.54600  45.20400  1.000 17.72385  ?  267 ILE   B CD1  1 
ATOM   2839 N  N    . MET   C 1 116 ? 31.49600  -2.51100  48.53100  1.000 16.51116  ?  268 MET   B N    1 
ATOM   2840 C  CA   . MET   C 1 116 ? 32.70200  -3.29300  48.79000  1.000 19.99870  ?  268 MET   B CA   1 
ATOM   2841 C  C    . MET   C 1 116 ? 32.65400  -3.93400  50.17000  1.000 22.64155  ?  268 MET   B C    1 
ATOM   2842 O  O    . MET   C 1 116 ? 33.04700  -5.09600  50.33800  1.000 16.15724  ?  268 MET   B O    1 
ATOM   2843 C  CB   . MET   C 1 116 ? 33.94300  -2.41100  48.65200  1.000 14.56116  ?  268 MET   B CB   1 
ATOM   2844 C  CG   . MET   C 1 116 ? 34.17400  -1.89000  47.24500  1.000 18.23906  ?  268 MET   B CG   1 
ATOM   2845 S  SD   . MET   C 1 116 ? 35.59900  -0.78700  47.16000  1.000 23.47576  ?  268 MET   B SD   1 
ATOM   2846 C  CE   . MET   C 1 116 ? 35.58300  -0.33000  45.42800  1.000 25.53724  ?  268 MET   B CE   1 
ATOM   2847 N  N    . LEU   C 1 117 ? 32.17100  -3.19000  51.17000  1.000 16.93459  ?  269 LEU   B N    1 
ATOM   2848 C  CA   . LEU   C 1 117 ? 32.02300  -3.74000  52.51400  1.000 15.27866  ?  269 LEU   B CA   1 
ATOM   2849 C  C    . LEU   C 1 117 ? 31.04900  -4.91000  52.52600  1.000 20.84521  ?  269 LEU   B C    1 
ATOM   2850 O  O    . LEU   C 1 117 ? 31.37700  -6.00100  53.00600  1.000 18.19314  ?  269 LEU   B O    1 
ATOM   2851 C  CB   . LEU   C 1 117 ? 31.54800  -2.65600  53.48300  1.000 18.83787  ?  269 LEU   B CB   1 
ATOM   2852 C  CG   . LEU   C 1 117 ? 32.56300  -1.77500  54.20100  1.000 30.16752  ?  269 LEU   B CG   1 
ATOM   2853 C  CD1  . LEU   C 1 117 ? 31.84000  -0.82700  55.14600  1.000 26.73178  ?  269 LEU   B CD1  1 
ATOM   2854 C  CD2  . LEU   C 1 117 ? 33.58400  -2.61100  54.96000  1.000 30.59091  ?  269 LEU   B CD2  1 
ATOM   2855 N  N    . ARG   C 1 118 ? 29.83400  -4.69900  52.01100  1.000 11.57762  ?  270 ARG   B N    1 
ATOM   2856 C  CA   . ARG   C 1 118 ? 28.82400  -5.74300  52.10600  1.000 17.56596  ?  270 ARG   B CA   1 
ATOM   2857 C  C    . ARG   C 1 118 ? 29.17300  -6.95400  51.25600  1.000 19.28909  ?  270 ARG   B C    1 
ATOM   2858 O  O    . ARG   C 1 118 ? 28.68800  -8.05000  51.53900  1.000 18.41686  ?  270 ARG   B O    1 
ATOM   2859 C  CB   . ARG   C 1 118 ? 27.44300  -5.20000  51.71900  1.000 21.66715  ?  270 ARG   B CB   1 
ATOM   2860 C  CG   . ARG   C 1 118 ? 27.24000  -4.94100  50.23800  1.000 23.33422  ?  270 ARG   B CG   1 
ATOM   2861 C  CD   . ARG   C 1 118 ? 26.02700  -4.03400  50.00100  1.000 26.85064  ?  270 ARG   B CD   1 
ATOM   2862 N  NE   . ARG   C 1 118 ? 24.75100  -4.72700  50.17500  1.000 24.35631  ?  270 ARG   B NE   1 
ATOM   2863 C  CZ   . ARG   C 1 118 ? 23.94900  -4.56800  51.22500  1.000 28.74854  ?  270 ARG   B CZ   1 
ATOM   2864 N  NH1  . ARG   C 1 118 ? 24.29100  -3.74300  52.20700  1.000 25.32879  ?  270 ARG   B NH1  1 
ATOM   2865 N  NH2  . ARG   C 1 118 ? 22.80300  -5.23600  51.29500  1.000 17.53863  ?  270 ARG   B NH2  1 
ATOM   2866 N  N    . SER   C 1 119 ? 30.01500  -6.79500  50.23700  1.000 17.52162  ?  271 SER   B N    1 
ATOM   2867 C  CA   . SER   C 1 119 ? 30.42600  -7.95300  49.45100  1.000 21.26583  ?  271 SER   B CA   1 
ATOM   2868 C  C    . SER   C 1 119 ? 31.24700  -8.94300  50.26600  1.000 18.80027  ?  271 SER   B C    1 
ATOM   2869 O  O    . SER   C 1 119 ? 31.35200  -10.11200 49.87300  1.000 19.44299  ?  271 SER   B O    1 
ATOM   2870 C  CB   . SER   C 1 119 ? 31.22300  -7.49800  48.22600  1.000 13.35995  ?  271 SER   B CB   1 
ATOM   2871 O  OG   . SER   C 1 119 ? 32.54900  -7.13600  48.57600  1.000 18.36343  ?  271 SER   B OG   1 
ATOM   2872 N  N    . ASN   C 1 120 ? 31.81900  -8.50500  51.39200  1.000 17.16685  ?  272 ASN   B N    1 
ATOM   2873 C  CA   . ASN   C 1 120 ? 32.72500  -9.35800  52.15200  1.000 17.13052  ?  272 ASN   B CA   1 
ATOM   2874 C  C    . ASN   C 1 120 ? 32.01700  -10.57500 52.73600  1.000 22.24743  ?  272 ASN   B C    1 
ATOM   2875 O  O    . ASN   C 1 120 ? 32.65100  -11.61400 52.95000  1.000 21.56112  ?  272 ASN   B O    1 
ATOM   2876 C  CB   . ASN   C 1 120 ? 33.39300  -8.54900  53.26300  1.000 18.68924  ?  272 ASN   B CB   1 
ATOM   2877 C  CG   . ASN   C 1 120 ? 34.57600  -9.27600  53.88400  1.000 27.47565  ?  272 ASN   B CG   1 
ATOM   2878 O  OD1  . ASN   C 1 120 ? 34.53200  -9.67100  55.05000  1.000 24.80204  ?  272 ASN   B OD1  1 
ATOM   2879 N  ND2  . ASN   C 1 120 ? 35.63800  -9.45500  53.10600  1.000 24.14633  ?  272 ASN   B ND2  1 
ATOM   2880 N  N    . GLN   C 1 121 ? 30.72800  -10.45500 52.95600  1.000 19.00220  ?  273 GLN   B N    1 
ATOM   2881 C  CA   . GLN   C 1 121 ? 29.94300  -11.56300 53.52900  1.000 21.66448  ?  273 GLN   B CA   1 
ATOM   2882 C  C    . GLN   C 1 121 ? 29.97100  -12.75600 52.56200  1.000 27.81593  ?  273 GLN   B C    1 
ATOM   2883 O  O    . GLN   C 1 121 ? 29.86900  -13.86000 53.01300  1.000 29.25601  ?  273 GLN   B O    1 
ATOM   2884 C  CB   . GLN   C 1 121 ? 28.55500  -11.01200 53.83900  1.000 28.03076  ?  273 GLN   B CB   1 
ATOM   2885 C  CG   . GLN   C 1 121 ? 27.57500  -11.99300 54.43000  1.000 26.42185  ?  273 GLN   B CG   1 
ATOM   2886 C  CD   . GLN   C 1 121 ? 26.35400  -11.29500 54.97300  1.000 41.38167  ?  273 GLN   B CD   1 
ATOM   2887 O  OE1  . GLN   C 1 121 ? 26.35400  -10.10500 55.27200  1.000 27.81230  ?  273 GLN   B OE1  1 
ATOM   2888 N  NE2  . GLN   C 1 121 ? 25.29400  -12.07500 55.13100  1.000 46.77567  ?  273 GLN   B NE2  1 
ATOM   2889 N  N    . SER   C 1 122 ? 30.05600  -12.49400 51.26700  1.000 18.20147  ?  274 SER   B N    1 
ATOM   2890 C  CA   . SER   C 1 122 ? 30.11100  -13.53300 50.25200  1.000 20.09614  ?  274 SER   B CA   1 
ATOM   2891 C  C    . SER   C 1 122 ? 31.53700  -13.92500 49.89100  1.000 21.74833  ?  274 SER   B C    1 
ATOM   2892 O  O    . SER   C 1 122 ? 31.73300  -14.91600 49.18200  1.000 21.39820  ?  274 SER   B O    1 
ATOM   2893 C  CB   . SER   C 1 122 ? 29.38400  -13.07100 48.98400  1.000 25.31187  ?  274 SER   B CB   1 
ATOM   2894 O  OG   . SER   C 1 122 ? 30.19800  -12.17800 48.24100  1.000 35.99964  ?  274 SER   B OG   1 
ATOM   2895 N  N    . PHE   C 1 123 ? 32.52700  -13.17400 50.35800  1.000 23.37461  ?  275 PHE   B N    1 
ATOM   2896 C  CA   . PHE   C 1 123 ? 33.90700  -13.40500 49.95400  1.000 22.71519  ?  275 PHE   B CA   1 
ATOM   2897 C  C    . PHE   C 1 123 ? 34.46600  -14.65100 50.63100  1.000 34.54015  ?  275 PHE   B C    1 
ATOM   2898 O  O    . PHE   C 1 123 ? 34.25800  -14.87300 51.82400  1.000 31.08529  ?  275 PHE   B O    1 
ATOM   2899 C  CB   . PHE   C 1 123 ? 34.76500  -12.19300 50.29900  1.000 21.19172  ?  275 PHE   B CB   1 
ATOM   2900 C  CG   . PHE   C 1 123 ? 36.16800  -12.27500 49.76600  1.000 22.44568  ?  275 PHE   B CG   1 
ATOM   2901 C  CD1  . PHE   C 1 123 ? 36.42700  -12.07200 48.41900  1.000 21.87971  ?  275 PHE   B CD1  1 
ATOM   2902 C  CD2  . PHE   C 1 123 ? 37.22800  -12.55900 50.61400  1.000 28.13740  ?  275 PHE   B CD2  1 
ATOM   2903 C  CE1  . PHE   C 1 123 ? 37.72000  -12.14800 47.92600  1.000 23.77410  ?  275 PHE   B CE1  1 
ATOM   2904 C  CE2  . PHE   C 1 123 ? 38.52400  -12.63500 50.12900  1.000 29.19564  ?  275 PHE   B CE2  1 
ATOM   2905 C  CZ   . PHE   C 1 123 ? 38.76900  -12.42800 48.78400  1.000 30.26297  ?  275 PHE   B CZ   1 
ATOM   2906 N  N    . THR   C 1 124 ? 35.18100  -15.46200 49.86100  1.000 30.95940  ?  276 THR   B N    1 
ATOM   2907 C  CA   . THR   C 1 124 ? 35.78100  -16.68700 50.35600  1.000 42.72596  ?  276 THR   B CA   1 
ATOM   2908 C  C    . THR   C 1 124 ? 37.29600  -16.61000 50.19500  1.000 33.35089  ?  276 THR   B C    1 
ATOM   2909 O  O    . THR   C 1 124 ? 37.80800  -16.11200 49.18700  1.000 36.45852  ?  276 THR   B O    1 
ATOM   2910 C  CB   . THR   C 1 124 ? 35.23800  -17.92400 49.62600  1.000 40.63341  ?  276 THR   B CB   1 
ATOM   2911 O  OG1  . THR   C 1 124 ? 35.81800  -19.09900 50.20600  1.000 59.90567  ?  276 THR   B OG1  1 
ATOM   2912 C  CG2  . THR   C 1 124 ? 35.55200  -17.88000 48.13800  1.000 33.87644  ?  276 THR   B CG2  1 
ATOM   2913 N  N    . MET   C 1 125 ? 38.01400  -17.05500 51.21800  1.000 38.41654  ?  277 MET   B N    1 
ATOM   2914 C  CA   . MET   C 1 125 ? 39.45600  -17.15900 51.10100  1.000 48.39108  ?  277 MET   B CA   1 
ATOM   2915 C  C    . MET   C 1 125 ? 39.90600  -18.51800 50.57000  1.000 47.88934  ?  277 MET   B C    1 
ATOM   2916 O  O    . MET   C 1 125 ? 41.11800  -18.74900 50.45900  1.000 56.40385  ?  277 MET   B O    1 
ATOM   2917 C  CB   . MET   C 1 125 ? 40.13300  -16.85600 52.44900  1.000 53.69390  ?  277 MET   B CB   1 
ATOM   2918 C  CG   . MET   C 1 125 ? 40.02700  -15.38400 52.83900  1.000 34.60355  ?  277 MET   B CG   1 
ATOM   2919 S  SD   . MET   C 1 125 ? 41.37200  -14.82400 53.89600  1.000 54.50753  ?  277 MET   B SD   1 
ATOM   2920 C  CE   . MET   C 1 125 ? 40.57900  -14.82900 55.49700  1.000 34.49545  ?  277 MET   B CE   1 
ATOM   2921 N  N    . ASP   C 1 126 ? 38.96800  -19.41500 50.23200  1.000 46.74737  ?  278 ASP   B N    1 
ATOM   2922 C  CA   . ASP   C 1 126 ? 39.32100  -20.61300 49.47300  1.000 57.79607  ?  278 ASP   B CA   1 
ATOM   2923 C  C    . ASP   C 1 126 ? 40.14400  -20.22900 48.24700  1.000 51.18832  ?  278 ASP   B C    1 
ATOM   2924 O  O    . ASP   C 1 126 ? 41.28400  -20.67800 48.06000  1.000 64.29684  ?  278 ASP   B O    1 
ATOM   2925 C  CB   . ASP   C 1 126 ? 38.07400  -21.38900 49.00800  1.000 56.91392  ?  278 ASP   B CB   1 
ATOM   2926 C  CG   . ASP   C 1 126 ? 37.08600  -21.67900 50.10500  1.000 65.50377  ?  278 ASP   B CG   1 
ATOM   2927 O  OD1  . ASP   C 1 126 ? 37.25900  -21.14000 51.23200  1.000 78.42149  ?  278 ASP   B OD1  1 
ATOM   2928 O  OD2  . ASP   C 1 126 ? 36.15400  -22.48400 49.81900  1.000 77.68512  ?  278 ASP   B OD2  1 
ATOM   2929 N  N    . ASP   C 1 127 ? 39.57900  -19.35000 47.41200  1.000 55.79486  ?  279 ASP   B N    1 
ATOM   2930 C  CA   . ASP   C 1 127 ? 40.19400  -18.99400 46.14100  1.000 42.91968  ?  279 ASP   B CA   1 
ATOM   2931 C  C    . ASP   C 1 127 ? 40.02600  -17.51400 45.81500  1.000 45.45711  ?  279 ASP   B C    1 
ATOM   2932 O  O    . ASP   C 1 127 ? 40.07700  -17.14400 44.63500  1.000 43.11796  ?  279 ASP   B O    1 
ATOM   2933 C  CB   . ASP   C 1 127 ? 39.61200  -19.84600 45.00500  1.000 45.35930  ?  279 ASP   B CB   1 
ATOM   2934 C  CG   . ASP   C 1 127 ? 38.12900  -19.60400 44.79100  1.000 57.87019  ?  279 ASP   B CG   1 
ATOM   2935 O  OD1  . ASP   C 1 127 ? 37.66100  -19.77200 43.64400  1.000 53.85075  ?  279 ASP   B OD1  1 
ATOM   2936 O  OD2  . ASP   C 1 127 ? 37.43100  -19.25500 45.76700  1.000 54.90836  ?  279 ASP   B OD2  1 
ATOM   2937 N  N    A MET   C 1 128 ? 39.82700  -16.66600 46.82500  0.500 41.11729  ?  280 MET   B N    1 
ATOM   2938 N  N    B MET   C 1 128 ? 39.82500  -16.66600 46.82600  0.500 41.11757  ?  280 MET   B N    1 
ATOM   2939 C  CA   A MET   C 1 128 ? 39.69700  -15.22000 46.64200  0.500 41.94159  ?  280 MET   B CA   1 
ATOM   2940 C  CA   B MET   C 1 128 ? 39.69600  -15.22000 46.64500  0.500 41.94010  ?  280 MET   B CA   1 
ATOM   2941 C  C    A MET   C 1 128 ? 38.59800  -14.88500 45.63600  0.500 34.47808  ?  280 MET   B C    1 
ATOM   2942 C  C    B MET   C 1 128 ? 38.59800  -14.88400 45.63900  0.500 34.47783  ?  280 MET   B C    1 
ATOM   2943 O  O    A MET   C 1 128 ? 38.81400  -14.17900 44.65000  0.500 37.60724  ?  280 MET   B O    1 
ATOM   2944 O  O    B MET   C 1 128 ? 38.81500  -14.17600 44.65400  0.500 37.60632  ?  280 MET   B O    1 
ATOM   2945 C  CB   A MET   C 1 128 ? 41.03100  -14.60000 46.22100  0.500 42.40784  ?  280 MET   B CB   1 
ATOM   2946 C  CB   B MET   C 1 128 ? 41.03000  -14.60100 46.22400  0.500 42.40832  ?  280 MET   B CB   1 
ATOM   2947 C  CG   A MET   C 1 128 ? 42.22900  -15.11500 47.00100  0.500 47.63870  ?  280 MET   B CG   1 
ATOM   2948 C  CG   B MET   C 1 128 ? 42.23500  -15.15400 46.96600  0.500 47.64558  ?  280 MET   B CG   1 
ATOM   2949 S  SD   A MET   C 1 128 ? 42.23300  -14.55000 48.71300  0.500 56.40751  ?  280 MET   B SD   1 
ATOM   2950 S  SD   B MET   C 1 128 ? 42.31900  -14.60400 48.67900  0.500 56.51682  ?  280 MET   B SD   1 
ATOM   2951 C  CE   A MET   C 1 128 ? 42.83300  -16.01100 49.55800  0.500 50.90039  ?  280 MET   B CE   1 
ATOM   2952 C  CE   B MET   C 1 128 ? 44.02600  -14.06800 48.76300  0.500 41.57382  ?  280 MET   B CE   1 
ATOM   2953 N  N    . SER   C 1 129 ? 37.40200  -15.40700 45.89200  1.000 35.48155  ?  281 SER   B N    1 
ATOM   2954 C  CA   . SER   C 1 129 ? 36.25700  -15.16900 45.02800  1.000 39.31119  ?  281 SER   B CA   1 
ATOM   2955 C  C    . SER   C 1 129 ? 35.05400  -14.77400 45.87200  1.000 31.79956  ?  281 SER   B C    1 
ATOM   2956 O  O    . SER   C 1 129 ? 35.04400  -14.93300 47.09600  1.000 25.58468  ?  281 SER   B O    1 
ATOM   2957 C  CB   . SER   C 1 129 ? 35.92100  -16.39900 44.17200  1.000 36.30007  ?  281 SER   B CB   1 
ATOM   2958 O  OG   . SER   C 1 129 ? 35.53000  -17.49600 44.97700  1.000 40.27830  ?  281 SER   B OG   1 
ATOM   2959 N  N    . TRP   C 1 130 ? 34.04200  -14.23700 45.19500  1.000 24.44576  ?  282 TRP   B N    1 
ATOM   2960 C  CA   . TRP   C 1 130 ? 32.77400  -13.87700 45.81800  1.000 23.32490  ?  282 TRP   B CA   1 
ATOM   2961 C  C    . TRP   C 1 130 ? 31.75600  -14.95500 45.45300  1.000 24.03752  ?  282 TRP   B C    1 
ATOM   2962 O  O    . TRP   C 1 130 ? 31.31100  -15.03400 44.30400  1.000 33.05263  ?  282 TRP   B O    1 
ATOM   2963 C  CB   . TRP   C 1 130 ? 32.31300  -12.49400 45.35600  1.000 19.32642  ?  282 TRP   B CB   1 
ATOM   2964 C  CG   . TRP   C 1 130 ? 33.11400  -11.33900 45.92500  1.000 20.47679  ?  282 TRP   B CG   1 
ATOM   2965 C  CD1  . TRP   C 1 130 ? 32.83700  -10.63100 47.06100  1.000 19.00905  ?  282 TRP   B CD1  1 
ATOM   2966 C  CD2  . TRP   C 1 130 ? 34.29900  -10.74800 45.36800  1.000 19.10326  ?  282 TRP   B CD2  1 
ATOM   2967 N  NE1  . TRP   C 1 130 ? 33.77800  -9.64700  47.25000  1.000 19.97793  ?  282 TRP   B NE1  1 
ATOM   2968 C  CE2  . TRP   C 1 130 ? 34.68300  -9.69500  46.22400  1.000 21.24311  ?  282 TRP   B CE2  1 
ATOM   2969 C  CE3  . TRP   C 1 130 ? 35.06900  -11.00500 44.23000  1.000 26.31140  ?  282 TRP   B CE3  1 
ATOM   2970 C  CZ2  . TRP   C 1 130 ? 35.80400  -8.90400  45.97900  1.000 19.25337  ?  282 TRP   B CZ2  1 
ATOM   2971 C  CZ3  . TRP   C 1 130 ? 36.18500  -10.21700 43.99100  1.000 20.31108  ?  282 TRP   B CZ3  1 
ATOM   2972 C  CH2  . TRP   C 1 130 ? 36.54000  -9.18100  44.86200  1.000 27.51889  ?  282 TRP   B CH2  1 
ATOM   2973 N  N    . ASP   C 1 131 ? 31.38900  -15.77800 46.43400  1.000 29.92152  ?  283 ASP   B N    1 
ATOM   2974 C  CA   . ASP   C 1 131 ? 30.59500  -16.98500 46.21400  1.000 31.90108  ?  283 ASP   B CA   1 
ATOM   2975 C  C    . ASP   C 1 131 ? 29.14100  -16.70400 46.57600  1.000 26.52411  ?  283 ASP   B C    1 
ATOM   2976 O  O    . ASP   C 1 131 ? 28.81400  -16.50100 47.75100  1.000 41.16082  ?  283 ASP   B O    1 
ATOM   2977 C  CB   . ASP   C 1 131 ? 31.15300  -18.14100 47.04400  1.000 45.70977  ?  283 ASP   B CB   1 
ATOM   2978 C  CG   . ASP   C 1 131 ? 30.47100  -19.46900 46.74500  1.000 49.72412  ?  283 ASP   B CG   1 
ATOM   2979 O  OD1  . ASP   C 1 131 ? 29.53900  -19.50700 45.91400  1.000 41.44680  ?  283 ASP   B OD1  1 
ATOM   2980 O  OD2  . ASP   C 1 131 ? 30.87200  -20.48300 47.35500  1.000 58.39390  ?  283 ASP   B OD2  1 
ATOM   2981 N  N    . CYS   C 1 132 ? 28.26600  -16.72900 45.57300  1.000 28.85847  ?  284 CYS   B N    1 
ATOM   2982 C  CA   . CYS   C 1 132 ? 26.84300  -16.46400 45.76300  1.000 37.69983  ?  284 CYS   B CA   1 
ATOM   2983 C  C    . CYS   C 1 132 ? 25.97000  -17.66300 45.41600  1.000 50.82841  ?  284 CYS   B C    1 
ATOM   2984 O  O    . CYS   C 1 132 ? 24.88300  -17.51500 44.85300  1.000 51.98620  ?  284 CYS   B O    1 
ATOM   2985 C  CB   . CYS   C 1 132 ? 26.41300  -15.25500 44.94900  1.000 40.31444  ?  284 CYS   B CB   1 
ATOM   2986 S  SG   . CYS   C 1 132 ? 27.39600  -13.86000 45.36700  1.000 44.76674  ?  284 CYS   B SG   1 
ATOM   2987 N  N    . GLY   C 1 133 ? 26.42900  -18.86000 45.76400  1.000 59.62814  ?  285 GLY   B N    1 
ATOM   2988 C  CA   . GLY   C 1 133 ? 25.60000  -20.03800 45.62200  1.000 66.80843  ?  285 GLY   B CA   1 
ATOM   2989 C  C    . GLY   C 1 133 ? 26.02000  -20.97000 44.50800  1.000 68.85218  ?  285 GLY   B C    1 
ATOM   2990 O  O    . GLY   C 1 133 ? 26.25500  -22.15700 44.74900  1.000 63.34963  ?  285 GLY   B O    1 
ATOM   2991 N  N    . SER   C 1 134 ? 26.10800  -20.45500 43.28700  1.000 58.63208  ?  286 SER   B N    1 
ATOM   2992 C  CA   . SER   C 1 134 ? 26.43800  -21.25000 42.11300  1.000 61.85823  ?  286 SER   B CA   1 
ATOM   2993 C  C    . SER   C 1 134 ? 27.78700  -20.81900 41.55100  1.000 56.70335  ?  286 SER   B C    1 
ATOM   2994 O  O    . SER   C 1 134 ? 28.36000  -19.80200 41.94700  1.000 49.69210  ?  286 SER   B O    1 
ATOM   2995 C  CB   . SER   C 1 134 ? 25.34800  -21.12000 41.04400  1.000 51.92846  ?  286 SER   B CB   1 
ATOM   2996 O  OG   . SER   C 1 134 ? 24.06700  -21.00900 41.64000  1.000 65.75305  ?  286 SER   B OG   1 
ATOM   2997 N  N    . GLN   C 1 135 ? 28.29600  -21.62200 40.61600  1.000 61.23913  ?  287 GLN   B N    1 
ATOM   2998 C  CA   . GLN   C 1 135 ? 29.56900  -21.31200 39.98000  1.000 49.33561  ?  287 GLN   B CA   1 
ATOM   2999 C  C    . GLN   C 1 135 ? 29.44500  -20.22800 38.91600  1.000 55.77956  ?  287 GLN   B C    1 
ATOM   3000 O  O    . GLN   C 1 135 ? 30.44100  -19.55800 38.61900  1.000 52.63393  ?  287 GLN   B O    1 
ATOM   3001 C  CB   . GLN   C 1 135 ? 30.17800  -22.57800 39.36700  1.000 56.53797  ?  287 GLN   B CB   1 
ATOM   3002 C  CG   . GLN   C 1 135 ? 31.67400  -22.73900 39.62800  1.000 71.26557  ?  287 GLN   B CG   1 
ATOM   3003 C  CD   . GLN   C 1 135 ? 31.98800  -23.25500 41.02500  1.000 71.20958  ?  287 GLN   B CD   1 
ATOM   3004 O  OE1  . GLN   C 1 135 ? 31.09000  -23.49000 41.83400  1.000 65.10125  ?  287 GLN   B OE1  1 
ATOM   3005 N  NE2  . GLN   C 1 135 ? 33.27400  -23.42800 41.31400  1.000 73.29152  ?  287 GLN   B NE2  1 
ATOM   3006 N  N    . ASP   C 1 136 ? 28.25500  -20.04500 38.33200  1.000 50.98075  ?  288 ASP   B N    1 
ATOM   3007 C  CA   . ASP   C 1 136 ? 28.04500  -18.89800 37.45200  1.000 52.20082  ?  288 ASP   B CA   1 
ATOM   3008 C  C    . ASP   C 1 136 ? 27.89800  -17.60900 38.24500  1.000 51.74904  ?  288 ASP   B C    1 
ATOM   3009 O  O    . ASP   C 1 136 ? 28.26000  -16.53400 37.75400  1.000 39.99348  ?  288 ASP   B O    1 
ATOM   3010 C  CB   . ASP   C 1 136 ? 26.81800  -19.11100 36.56600  1.000 57.05843  ?  288 ASP   B CB   1 
ATOM   3011 C  CG   . ASP   C 1 136 ? 26.93700  -20.33900 35.69200  1.000 73.51377  ?  288 ASP   B CG   1 
ATOM   3012 O  OD1  . ASP   C 1 136 ? 26.33900  -21.38100 36.03500  1.000 80.45802  ?  288 ASP   B OD1  1 
ATOM   3013 O  OD2  . ASP   C 1 136 ? 27.63300  -20.25800 34.65900  1.000 72.09225  ?  288 ASP   B OD2  1 
ATOM   3014 N  N    . TYR   C 1 137 ? 27.37100  -17.69000 39.46700  1.000 43.53396  ?  289 TYR   B N    1 
ATOM   3015 C  CA   . TYR   C 1 137 ? 27.33600  -16.56000 40.38700  1.000 29.35634  ?  289 TYR   B CA   1 
ATOM   3016 C  C    . TYR   C 1 137 ? 28.48200  -16.61000 41.38800  1.000 36.84172  ?  289 TYR   B C    1 
ATOM   3017 O  O    . TYR   C 1 137 ? 28.32500  -16.22300 42.54900  1.000 41.84387  ?  289 TYR   B O    1 
ATOM   3018 C  CB   . TYR   C 1 137 ? 25.98600  -16.49900 41.09800  1.000 36.74348  ?  289 TYR   B CB   1 
ATOM   3019 C  CG   . TYR   C 1 137 ? 24.82300  -16.41600 40.13500  1.000 32.21296  ?  289 TYR   B CG   1 
ATOM   3020 C  CD1  . TYR   C 1 137 ? 23.62000  -17.05100 40.40600  1.000 47.69443  ?  289 TYR   B CD1  1 
ATOM   3021 C  CD2  . TYR   C 1 137 ? 24.93700  -15.70700 38.94500  1.000 36.63545  ?  289 TYR   B CD2  1 
ATOM   3022 C  CE1  . TYR   C 1 137 ? 22.55900  -16.97800 39.52200  1.000 37.49608  ?  289 TYR   B CE1  1 
ATOM   3023 C  CE2  . TYR   C 1 137 ? 23.88300  -15.63000 38.05600  1.000 32.71863  ?  289 TYR   B CE2  1 
ATOM   3024 C  CZ   . TYR   C 1 137 ? 22.69800  -16.26600 38.34800  1.000 42.41486  ?  289 TYR   B CZ   1 
ATOM   3025 O  OH   . TYR   C 1 137 ? 21.64400  -16.19100 37.46600  1.000 39.04007  ?  289 TYR   B OH   1 
ATOM   3026 N  N    . LYS   C 1 138 ? 29.62800  -17.12400 40.95800  1.000 39.44360  ?  290 LYS   B N    1 
ATOM   3027 C  CA   . LYS   C 1 138 ? 30.88500  -17.02900 41.69000  1.000 43.83997  ?  290 LYS   B CA   1 
ATOM   3028 C  C    . LYS   C 1 138 ? 31.79800  -16.09500 40.90600  1.000 37.13942  ?  290 LYS   B C    1 
ATOM   3029 O  O    . LYS   C 1 138 ? 32.16000  -16.39200 39.76100  1.000 38.82592  ?  290 LYS   B O    1 
ATOM   3030 C  CB   . LYS   C 1 138 ? 31.53400  -18.40100 41.86500  1.000 39.98384  ?  290 LYS   B CB   1 
ATOM   3031 C  CG   . LYS   C 1 138 ? 32.90600  -18.36300 42.52500  1.000 47.17868  ?  290 LYS   B CG   1 
ATOM   3032 C  CD   . LYS   C 1 138 ? 33.31900  -19.74200 43.01400  1.000 51.70581  ?  290 LYS   B CD   1 
ATOM   3033 C  CE   . LYS   C 1 138 ? 33.06300  -19.90300 44.50100  1.000 57.23838  ?  290 LYS   B CE   1 
ATOM   3034 N  NZ   . LYS   C 1 138 ? 34.20500  -19.41700 45.32300  1.000 54.21294  ?  290 LYS   B NZ   1 
ATOM   3035 N  N    . TYR   C 1 139 ? 32.15800  -14.97100 41.51400  1.000 29.22850  ?  291 TYR   B N    1 
ATOM   3036 C  CA   . TYR   C 1 139 ? 32.90000  -13.91900 40.83500  1.000 27.29667  ?  291 TYR   B CA   1 
ATOM   3037 C  C    . TYR   C 1 139 ? 34.33500  -13.89400 41.33600  1.000 22.91768  ?  291 TYR   B C    1 
ATOM   3038 O  O    . TYR   C 1 139 ? 34.57400  -13.88500 42.54700  1.000 30.69706  ?  291 TYR   B O    1 
ATOM   3039 C  CB   . TYR   C 1 139 ? 32.22700  -12.56300 41.05300  1.000 23.53609  ?  291 TYR   B CB   1 
ATOM   3040 C  CG   . TYR   C 1 139 ? 30.73500  -12.61200 40.81400  1.000 22.65881  ?  291 TYR   B CG   1 
ATOM   3041 C  CD1  . TYR   C 1 139 ? 29.84000  -12.58200 41.87400  1.000 28.69312  ?  291 TYR   B CD1  1 
ATOM   3042 C  CD2  . TYR   C 1 139 ? 30.22400  -12.71100 39.52700  1.000 25.94137  ?  291 TYR   B CD2  1 
ATOM   3043 C  CE1  . TYR   C 1 139 ? 28.47400  -12.63300 41.65800  1.000 31.01280  ?  291 TYR   B CE1  1 
ATOM   3044 C  CE2  . TYR   C 1 139 ? 28.85900  -12.76600 39.29900  1.000 29.74279  ?  291 TYR   B CE2  1 
ATOM   3045 C  CZ   . TYR   C 1 139 ? 27.99000  -12.72700 40.36900  1.000 23.01324  ?  291 TYR   B CZ   1 
ATOM   3046 O  OH   . TYR   C 1 139 ? 26.63600  -12.77900 40.15400  1.000 24.98088  ?  291 TYR   B OH   1 
ATOM   3047 N  N    . ASP   C 1 140 ? 35.28200  -13.88500 40.40500  1.000 33.75146  ?  292 ASP   B N    1 
ATOM   3048 C  CA   . ASP   C 1 140 ? 36.69800  -13.83400 40.73800  1.000 38.80081  ?  292 ASP   B CA   1 
ATOM   3049 C  C    . ASP   C 1 140 ? 37.33600  -12.59900 40.09800  1.000 28.17514  ?  292 ASP   B C    1 
ATOM   3050 O  O    . ASP   C 1 140 ? 36.64600  -11.72300 39.56500  1.000 28.74547  ?  292 ASP   B O    1 
ATOM   3051 C  CB   . ASP   C 1 140 ? 37.39800  -15.13600 40.32700  1.000 34.45892  ?  292 ASP   B CB   1 
ATOM   3052 C  CG   . ASP   C 1 140 ? 37.39900  -15.36900 38.82200  1.000 35.09271  ?  292 ASP   B CG   1 
ATOM   3053 O  OD1  . ASP   C 1 140 ? 38.01300  -16.36600 38.39000  1.000 48.48495  ?  292 ASP   B OD1  1 
ATOM   3054 O  OD2  . ASP   C 1 140 ? 36.78800  -14.58000 38.06900  1.000 36.24046  ?  292 ASP   B OD2  1 
ATOM   3055 N  N    . VAL   C 1 141 ? 38.64300  -12.51200 40.19400  1.000 30.79529  ?  293 VAL   B N    1 
ATOM   3056 C  CA   . VAL   C 1 141 ? 39.34000  -11.31900 39.64600  1.000 29.70790  ?  293 VAL   B CA   1 
ATOM   3057 C  C    . VAL   C 1 141 ? 39.11100  -11.18500 38.13200  1.000 28.17916  ?  293 VAL   B C    1 
ATOM   3058 O  O    . VAL   C 1 141 ? 38.97000  -10.07800 37.67200  1.000 26.42960  ?  293 VAL   B O    1 
ATOM   3059 C  CB   . VAL   C 1 141 ? 40.82000  -11.38100 40.03600  1.000 30.03520  ?  293 VAL   B CB   1 
ATOM   3060 C  CG1  . VAL   C 1 141 ? 40.94200  -11.19800 41.52600  1.000 32.55275  ?  293 VAL   B CG1  1 
ATOM   3061 C  CG2  . VAL   C 1 141 ? 41.41400  -12.71000 39.64800  1.000 29.07384  ?  293 VAL   B CG2  1 
ATOM   3062 N  N    . THR   C 1 142 ? 39.05000  -12.28300 37.39100  1.000 29.03160  ?  294 THR   B N    1 
ATOM   3063 C  CA   . THR   C 1 142 ? 38.86100  -12.16400 35.94900  1.000 28.06850  ?  294 THR   B CA   1 
ATOM   3064 C  C    . THR   C 1 142 ? 37.46700  -11.65000 35.61000  1.000 31.67958  ?  294 THR   B C    1 
ATOM   3065 O  O    . THR   C 1 142 ? 37.29800  -10.90200 34.64300  1.000 29.71402  ?  294 THR   B O    1 
ATOM   3066 C  CB   . THR   C 1 142 ? 39.11800  -13.51000 35.27600  1.000 38.49446  ?  294 THR   B CB   1 
ATOM   3067 O  OG1  . THR   C 1 142 ? 38.14100  -14.46000 35.72000  1.000 50.25913  ?  294 THR   B OG1  1 
ATOM   3068 C  CG2  . THR   C 1 142 ? 40.50600  -14.01900 35.63500  1.000 26.48673  ?  294 THR   B CG2  1 
ATOM   3069 N  N    . ASP   C 1 143 ? 36.45700  -12.03400 36.39600  1.000 29.16569  ?  295 ASP   B N    1 
ATOM   3070 C  CA   . ASP   C 1 143 ? 35.11800  -11.49200 36.18600  1.000 29.43568  ?  295 ASP   B CA   1 
ATOM   3071 C  C    . ASP   C 1 143 ? 35.11000  -9.97600  36.34000  1.000 23.14834  ?  295 ASP   B C    1 
ATOM   3072 O  O    . ASP   C 1 143 ? 34.46600  -9.26900  35.55600  1.000 27.49026  ?  295 ASP   B O    1 
ATOM   3073 C  CB   . ASP   C 1 143 ? 34.12800  -12.13200 37.16200  1.000 38.73658  ?  295 ASP   B CB   1 
ATOM   3074 C  CG   . ASP   C 1 143 ? 33.85600  -13.59300 36.84800  1.000 38.45089  ?  295 ASP   B CG   1 
ATOM   3075 O  OD1  . ASP   C 1 143 ? 33.74400  -13.94000 35.65400  1.000 35.08767  ?  295 ASP   B OD1  1 
ATOM   3076 O  OD2  . ASP   C 1 143 ? 33.74700  -14.39700 37.79800  1.000 37.05509  ?  295 ASP   B OD2  1 
ATOM   3077 N  N    . VAL   C 1 144 ? 35.82000  -9.45800  37.34600  1.000 24.38707  ?  296 VAL   B N    1 
ATOM   3078 C  CA   . VAL   C 1 144 ? 35.86500  -8.01200  37.54300  1.000 24.74242  ?  296 VAL   B CA   1 
ATOM   3079 C  C    . VAL   C 1 144 ? 36.60400  -7.34200  36.39200  1.000 23.42175  ?  296 VAL   B C    1 
ATOM   3080 O  O    . VAL   C 1 144 ? 36.20000  -6.27400  35.91600  1.000 17.81189  ?  296 VAL   B O    1 
ATOM   3081 C  CB   . VAL   C 1 144 ? 36.50000  -7.67000  38.90400  1.000 27.84056  ?  296 VAL   B CB   1 
ATOM   3082 C  CG1  . VAL   C 1 144 ? 36.45300  -6.17000  39.14700  1.000 21.64299  ?  296 VAL   B CG1  1 
ATOM   3083 C  CG2  . VAL   C 1 144 ? 35.78900  -8.41000  40.02900  1.000 25.73685  ?  296 VAL   B CG2  1 
ATOM   3084 N  N    . SER   C 1 145 ? 37.69500  -7.95500  35.92000  1.000 24.19378  ?  297 SER   B N    1 
ATOM   3085 C  CA   . SER   C 1 145 ? 38.40300  -7.38800  34.77700  1.000 22.52130  ?  297 SER   B CA   1 
ATOM   3086 C  C    . SER   C 1 145 ? 37.53300  -7.39300  33.52700  1.000 19.59273  ?  297 SER   B C    1 
ATOM   3087 O  O    . SER   C 1 145 ? 37.65800  -6.50000  32.68200  1.000 26.61538  ?  297 SER   B O    1 
ATOM   3088 C  CB   . SER   C 1 145 ? 39.71200  -8.14200  34.52600  1.000 26.63370  ?  297 SER   B CB   1 
ATOM   3089 O  OG   . SER   C 1 145 ? 39.48100  -9.49600  34.18600  1.000 30.48886  ?  297 SER   B OG   1 
ATOM   3090 N  N    . LYS   C 1 146 ? 36.63800  -8.37600  33.39700  1.000 22.67046  ?  298 LYS   B N    1 
ATOM   3091 C  CA   . LYS   C 1 146 ? 35.69900  -8.41600  32.28100  1.000 29.39882  ?  298 LYS   B CA   1 
ATOM   3092 C  C    . LYS   C 1 146 ? 34.53900  -7.44100  32.44900  1.000 27.12106  ?  298 LYS   B C    1 
ATOM   3093 O  O    . LYS   C 1 146 ? 33.61500  -7.45300  31.63200  1.000 21.10157  ?  298 LYS   B O    1 
ATOM   3094 C  CB   . LYS   C 1 146 ? 35.16200  -9.83800  32.08300  1.000 28.72457  ?  298 LYS   B CB   1 
ATOM   3095 C  CG   . LYS   C 1 146 ? 36.21400  -10.84900 31.65300  1.000 36.49542  ?  298 LYS   B CG   1 
ATOM   3096 C  CD   . LYS   C 1 146 ? 35.58500  -12.01200 30.89800  1.000 48.34210  ?  298 LYS   B CD   1 
ATOM   3097 C  CE   . LYS   C 1 146 ? 36.53500  -13.19900 30.81700  1.000 53.41690  ?  298 LYS   B CE   1 
ATOM   3098 N  NZ   . LYS   C 1 146 ? 35.95400  -14.42300 31.44100  1.000 50.09925  ?  298 LYS   B NZ   1 
ATOM   3099 N  N    . ALA   C 1 147 ? 34.55600  -6.61700  33.49400  1.000 24.53482  ?  299 ALA   B N    1 
ATOM   3100 C  CA   . ALA   C 1 147 ? 33.69300  -5.44900  33.58500  1.000 23.15828  ?  299 ALA   B CA   1 
ATOM   3101 C  C    . ALA   C 1 147 ? 34.44800  -4.15800  33.29100  1.000 26.42953  ?  299 ALA   B C    1 
ATOM   3102 O  O    . ALA   C 1 147 ? 33.86700  -3.07300  33.39000  1.000 28.25838  ?  299 ALA   B O    1 
ATOM   3103 C  CB   . ALA   C 1 147 ? 33.03800  -5.37300  34.96800  1.000 26.49131  ?  299 ALA   B CB   1 
ATOM   3104 N  N    . GLY   C 1 148 ? 35.72800  -4.25200  32.93100  1.000 25.81290  ?  300 GLY   B N    1 
ATOM   3105 C  CA   . GLY   C 1 148 ? 36.50200  -3.10000  32.51500  1.000 18.62664  ?  300 GLY   B CA   1 
ATOM   3106 C  C    . GLY   C 1 148 ? 37.54400  -2.62900  33.50100  1.000 20.48453  ?  300 GLY   B C    1 
ATOM   3107 O  O    . GLY   C 1 148 ? 38.27600  -1.68400  33.19100  1.000 22.19154  ?  300 GLY   B O    1 
ATOM   3108 N  N    . HIS   C 1 149 ? 37.65100  -3.24900  34.67000  1.000 23.43757  ?  301 HIS   B N    1 
ATOM   3109 C  CA   . HIS   C 1 149 ? 38.56800  -2.76400  35.68800  1.000 16.62787  ?  301 HIS   B CA   1 
ATOM   3110 C  C    . HIS   C 1 149 ? 39.92400  -3.45500  35.58300  1.000 27.05987  ?  301 HIS   B C    1 
ATOM   3111 O  O    . HIS   C 1 149 ? 40.03300  -4.59900  35.13300  1.000 25.28523  ?  301 HIS   B O    1 
ATOM   3112 C  CB   . HIS   C 1 149 ? 37.97100  -2.95700  37.08400  1.000 19.86727  ?  301 HIS   B CB   1 
ATOM   3113 C  CG   . HIS   C 1 149 ? 36.86900  -1.99300  37.39500  1.000 23.00548  ?  301 HIS   B CG   1 
ATOM   3114 N  ND1  . HIS   C 1 149 ? 37.08400  -0.63800  37.53400  1.000 20.00813  ?  301 HIS   B ND1  1 
ATOM   3115 C  CD2  . HIS   C 1 149 ? 35.54000  -2.18300  37.56900  1.000 21.91857  ?  301 HIS   B CD2  1 
ATOM   3116 C  CE1  . HIS   C 1 149 ? 35.93500  -0.03600  37.78800  1.000 21.64016  ?  301 HIS   B CE1  1 
ATOM   3117 N  NE2  . HIS   C 1 149 ? 34.98300  -0.95100  37.81400  1.000 20.08483  ?  301 HIS   B NE2  1 
ATOM   3118 N  N    . THR   C 1 150 ? 40.96100  -2.73300  35.99000  1.000 24.78324  ?  302 THR   B N    1 
ATOM   3119 C  CA   . THR   C 1 150 ? 42.33300  -3.21400  35.94800  1.000 27.40952  ?  302 THR   B CA   1 
ATOM   3120 C  C    . THR   C 1 150 ? 42.79100  -3.63500  37.33900  1.000 29.68960  ?  302 THR   B C    1 
ATOM   3121 O  O    . THR   C 1 150 ? 42.09900  -3.43500  38.33900  1.000 17.04205  ?  302 THR   B O    1 
ATOM   3122 C  CB   . THR   C 1 150 ? 43.26300  -2.13500  35.39100  1.000 23.59603  ?  302 THR   B CB   1 
ATOM   3123 O  OG1  . THR   C 1 150 ? 43.42600  -1.09800  36.36600  1.000 26.79199  ?  302 THR   B OG1  1 
ATOM   3124 C  CG2  . THR   C 1 150 ? 42.68700  -1.54500  34.11200  1.000 24.93256  ?  302 THR   B CG2  1 
ATOM   3125 N  N    . LEU   C 1 151 ? 43.98800  -4.22100  37.39600  1.000 23.27463  ?  303 LEU   B N    1 
ATOM   3126 C  CA   . LEU   C 1 151 ? 44.52200  -4.68200  38.67100  1.000 22.99006  ?  303 LEU   B CA   1 
ATOM   3127 C  C    . LEU   C 1 151 ? 44.91200  -3.53800  39.59800  1.000 23.30315  ?  303 LEU   B C    1 
ATOM   3128 O  O    . LEU   C 1 151 ? 45.11000  -3.77700  40.79300  1.000 22.78207  ?  303 LEU   B O    1 
ATOM   3129 C  CB   . LEU   C 1 151 ? 45.71800  -5.60500  38.43300  1.000 32.71040  ?  303 LEU   B CB   1 
ATOM   3130 C  CG   . LEU   C 1 151 ? 45.36900  -6.91300  37.71900  1.000 33.04906  ?  303 LEU   B CG   1 
ATOM   3131 C  CD1  . LEU   C 1 151 ? 46.62200  -7.68000  37.33200  1.000 34.38568  ?  303 LEU   B CD1  1 
ATOM   3132 C  CD2  . LEU   C 1 151 ? 44.45300  -7.76900  38.58400  1.000 30.06782  ?  303 LEU   B CD2  1 
ATOM   3133 N  N    . GLU   C 1 152 ? 45.01900  -2.30900  39.08600  1.000 25.55796  ?  304 GLU   B N    1 
ATOM   3134 C  CA   . GLU   C 1 152 ? 45.23100  -1.16000  39.96100  1.000 23.55010  ?  304 GLU   B CA   1 
ATOM   3135 C  C    . GLU   C 1 152 ? 44.09800  -1.00900  40.97100  1.000 26.39254  ?  304 GLU   B C    1 
ATOM   3136 O  O    . GLU   C 1 152 ? 44.30600  -0.47100  42.06400  1.000 22.85768  ?  304 GLU   B O    1 
ATOM   3137 C  CB   . GLU   C 1 152 ? 45.37300  0.11500   39.12800  1.000 26.70590  ?  304 GLU   B CB   1 
ATOM   3138 C  CG   . GLU   C 1 152 ? 45.85300  1.33500   39.90700  1.000 38.13449  ?  304 GLU   B CG   1 
ATOM   3139 C  CD   . GLU   C 1 152 ? 47.19000  1.11400   40.59600  1.000 58.57191  ?  304 GLU   B CD   1 
ATOM   3140 O  OE1  . GLU   C 1 152 ? 48.03400  0.37200   40.04800  1.000 48.35346  ?  304 GLU   B OE1  1 
ATOM   3141 O  OE2  . GLU   C 1 152 ? 47.39800  1.68400   41.68900  1.000 61.01209  ?  304 GLU   B OE2  1 
ATOM   3142 N  N    . LEU   C 1 153 ? 42.89600  -1.46400  40.62100  1.000 21.38943  ?  305 LEU   B N    1 
ATOM   3143 C  CA   . LEU   C 1 153 ? 41.78100  -1.52600  41.55700  1.000 22.07706  ?  305 LEU   B CA   1 
ATOM   3144 C  C    . LEU   C 1 153 ? 41.58900  -2.91400  42.14800  1.000 23.77721  ?  305 LEU   B C    1 
ATOM   3145 O  O    . LEU   C 1 153 ? 41.33000  -3.04000  43.34800  1.000 24.34967  ?  305 LEU   B O    1 
ATOM   3146 C  CB   . LEU   C 1 153 ? 40.48100  -1.08600  40.87400  1.000 19.16829  ?  305 LEU   B CB   1 
ATOM   3147 C  CG   . LEU   C 1 153 ? 39.21000  -1.10500  41.73500  1.000 16.01843  ?  305 LEU   B CG   1 
ATOM   3148 C  CD1  . LEU   C 1 153 ? 39.33600  -0.14900  42.91400  1.000 13.68280  ?  305 LEU   B CD1  1 
ATOM   3149 C  CD2  . LEU   C 1 153 ? 37.97900  -0.77400  40.90400  1.000 18.19677  ?  305 LEU   B CD2  1 
ATOM   3150 N  N    . ILE   C 1 154 ? 41.73400  -3.96300  41.33700  1.000 22.92394  ?  306 ILE   B N    1 
ATOM   3151 C  CA   . ILE   C 1 154 ? 41.38100  -5.30000  41.80200  1.000 20.28095  ?  306 ILE   B CA   1 
ATOM   3152 C  C    . ILE   C 1 154 ? 42.38100  -5.81700  42.83400  1.000 27.48966  ?  306 ILE   B C    1 
ATOM   3153 O  O    . ILE   C 1 154 ? 41.99900  -6.53400  43.76800  1.000 22.22895  ?  306 ILE   B O    1 
ATOM   3154 C  CB   . ILE   C 1 154 ? 41.24600  -6.26000  40.60900  1.000 23.28462  ?  306 ILE   B CB   1 
ATOM   3155 C  CG1  . ILE   C 1 154 ? 40.19500  -5.73600  39.62900  1.000 24.50864  ?  306 ILE   B CG1  1 
ATOM   3156 C  CG2  . ILE   C 1 154 ? 40.84100  -7.63600  41.08900  1.000 23.15029  ?  306 ILE   B CG2  1 
ATOM   3157 C  CD1  . ILE   C 1 154 ? 40.10500  -6.52900  38.33300  1.000 25.46313  ?  306 ILE   B CD1  1 
ATOM   3158 N  N    . GLU   C 1 155 ? 43.64600  -5.43300  42.69300  1.000 24.86638  ?  307 GLU   B N    1 
ATOM   3159 C  CA   . GLU   C 1 155 ? 44.66400  -5.90400  43.66000  1.000 24.47602  ?  307 GLU   B CA   1 
ATOM   3160 C  C    . GLU   C 1 155 ? 44.34200  -5.34000  45.04600  1.000 23.72109  ?  307 GLU   B C    1 
ATOM   3161 O  O    . GLU   C 1 155 ? 44.17100  -6.11900  45.96900  1.000 25.37750  ?  307 GLU   B O    1 
ATOM   3162 C  CB   . GLU   C 1 155 ? 46.08300  -5.57500  43.20300  1.000 32.09346  ?  307 GLU   B CB   1 
ATOM   3163 C  CG   . GLU   C 1 155 ? 47.09400  -5.70500  44.31700  1.000 43.92137  ?  307 GLU   B CG   1 
ATOM   3164 C  CD   . GLU   C 1 155 ? 48.35000  -4.87700  44.12300  1.000 58.09269  ?  307 GLU   B CD   1 
ATOM   3165 O  OE1  . GLU   C 1 155 ? 48.24400  -3.64200  44.01500  1.000 55.74883  ?  307 GLU   B OE1  1 
ATOM   3166 O  OE2  . GLU   C 1 155 ? 49.41100  -5.46800  44.06600  1.000 44.92605  ?  307 GLU   B OE2  1 
ATOM   3167 N  N    . PRO   C 1 156 ? 44.21900  -4.02000  45.24700  1.000 23.80579  ?  308 PRO   B N    1 
ATOM   3168 C  CA   . PRO   C 1 156 ? 43.89400  -3.53700  46.60000  1.000 23.34853  ?  308 PRO   B CA   1 
ATOM   3169 C  C    . PRO   C 1 156 ? 42.49600  -3.93000  47.04000  1.000 20.82063  ?  308 PRO   B C    1 
ATOM   3170 O  O    . PRO   C 1 156 ? 42.25100  -4.04000  48.24600  1.000 22.72835  ?  308 PRO   B O    1 
ATOM   3171 C  CB   . PRO   C 1 156 ? 44.05000  -2.01400  46.50100  1.000 23.81707  ?  308 PRO   B CB   1 
ATOM   3172 C  CG   . PRO   C 1 156 ? 43.92200  -1.69300  45.08400  1.000 33.40076  ?  308 PRO   B CG   1 
ATOM   3173 C  CD   . PRO   C 1 156 ? 44.28800  -2.90000  44.28100  1.000 23.18140  ?  308 PRO   B CD   1 
ATOM   3174 N  N    . LEU   C 1 157 ? 41.57700  -4.16200  46.09900  1.000 19.85091  ?  309 LEU   B N    1 
ATOM   3175 C  CA   . LEU   C 1 157 ? 40.24100  -4.62300  46.46500  1.000 19.29162  ?  309 LEU   B CA   1 
ATOM   3176 C  C    . LEU   C 1 157 ? 40.30100  -5.98300  47.14900  1.000 27.06172  ?  309 LEU   B C    1 
ATOM   3177 O  O    . LEU   C 1 157 ? 39.69600  -6.18700  48.20800  1.000 21.12197  ?  309 LEU   B O    1 
ATOM   3178 C  CB   . LEU   C 1 157 ? 39.34600  -4.68500  45.22600  1.000 16.97575  ?  309 LEU   B CB   1 
ATOM   3179 C  CG   . LEU   C 1 157 ? 37.92900  -5.22400  45.44500  1.000 23.03517  ?  309 LEU   B CG   1 
ATOM   3180 C  CD1  . LEU   C 1 157 ? 37.23100  -4.45800  46.55800  1.000 20.99913  ?  309 LEU   B CD1  1 
ATOM   3181 C  CD2  . LEU   C 1 157 ? 37.11700  -5.16500  44.15000  1.000 19.01713  ?  309 LEU   B CD2  1 
ATOM   3182 N  N    . ILE   C 1 158 ? 41.02400  -6.93100  46.55000  1.000 24.12106  ?  310 ILE   B N    1 
ATOM   3183 C  CA   . ILE   C 1 158 ? 41.14400  -8.26200  47.13700  1.000 23.23372  ?  310 ILE   B CA   1 
ATOM   3184 C  C    . ILE   C 1 158 ? 41.93300  -8.20800  48.43500  1.000 19.95526  ?  310 ILE   B C    1 
ATOM   3185 O  O    . ILE   C 1 158 ? 41.59100  -8.88700  49.41000  1.000 23.56270  ?  310 ILE   B O    1 
ATOM   3186 C  CB   . ILE   C 1 158 ? 41.78500  -9.22500  46.12800  1.000 29.67659  ?  310 ILE   B CB   1 
ATOM   3187 C  CG1  . ILE   C 1 158 ? 40.73300  -9.68600  45.13700  1.000 28.95553  ?  310 ILE   B CG1  1 
ATOM   3188 C  CG2  . ILE   C 1 158 ? 42.41600  -10.42300 46.82900  1.000 22.78067  ?  310 ILE   B CG2  1 
ATOM   3189 C  CD1  . ILE   C 1 158 ? 41.33900  -10.18300 43.91100  1.000 34.23829  ?  310 ILE   B CD1  1 
ATOM   3190 N  N    . LYS   C 1 159 ? 42.96800  -7.38100  48.45700  1.000 18.88819  ?  311 LYS   B N    1 
ATOM   3191 C  CA   . LYS   C 1 159 ? 43.74800  -7.19500  49.69900  1.000 22.06588  ?  311 LYS   B CA   1 
ATOM   3192 C  C    . LYS   C 1 159 ? 42.78700  -6.74600  50.80300  1.000 30.91736  ?  311 LYS   B C    1 
ATOM   3193 O  O    . LYS   C 1 159 ? 42.83400  -7.30100  51.89600  1.000 20.36419  ?  311 LYS   B O    1 
ATOM   3194 C  CB   . LYS   C 1 159 ? 44.78400  -6.09800  49.50900  1.000 27.93423  ?  311 LYS   B CB   1 
ATOM   3195 C  CG   . LYS   C 1 159 ? 46.21900  -6.57500  49.52400  1.000 44.46631  ?  311 LYS   B CG   1 
ATOM   3196 C  CD   . LYS   C 1 159 ? 47.18300  -5.41900  49.55400  1.000 53.94162  ?  311 LYS   B CD   1 
ATOM   3197 C  CE   . LYS   C 1 159 ? 47.12100  -4.64900  50.85100  1.000 58.59889  ?  311 LYS   B CE   1 
ATOM   3198 N  NZ   . LYS   C 1 159 ? 46.54400  -3.29700  50.65200  1.000 63.60310  ?  311 LYS   B NZ   1 
ATOM   3199 N  N    . PHE   C 1 160 ? 41.95800  -5.75500  50.48000  1.000 23.73963  ?  312 PHE   B N    1 
ATOM   3200 C  CA   . PHE   C 1 160 ? 40.98000  -5.26100  51.44100  1.000 19.23971  ?  312 PHE   B CA   1 
ATOM   3201 C  C    . PHE   C 1 160 ? 40.05700  -6.37800  51.91100  1.000 18.06968  ?  312 PHE   B C    1 
ATOM   3202 O  O    . PHE   C 1 160 ? 39.78800  -6.51300  53.11100  1.000 23.49717  ?  312 PHE   B O    1 
ATOM   3203 C  CB   . PHE   C 1 160 ? 40.17600  -4.12400  50.80300  1.000 22.51941  ?  312 PHE   B CB   1 
ATOM   3204 C  CG   . PHE   C 1 160 ? 38.98900  -3.68900  51.61000  1.000 20.50478  ?  312 PHE   B CG   1 
ATOM   3205 C  CD1  . PHE   C 1 160 ? 39.11700  -2.70700  52.57600  1.000 29.81002  ?  312 PHE   B CD1  1 
ATOM   3206 C  CD2  . PHE   C 1 160 ? 37.74300  -4.25600  51.39700  1.000 19.77748  ?  312 PHE   B CD2  1 
ATOM   3207 C  CE1  . PHE   C 1 160 ? 38.02800  -2.30300  53.32400  1.000 24.45673  ?  312 PHE   B CE1  1 
ATOM   3208 C  CE2  . PHE   C 1 160 ? 36.65000  -3.85900  52.14300  1.000 23.77230  ?  312 PHE   B CE2  1 
ATOM   3209 C  CZ   . PHE   C 1 160 ? 36.79600  -2.87900  53.10700  1.000 20.50093  ?  312 PHE   B CZ   1 
ATOM   3210 N  N    . GLN   C 1 161 ? 39.55900  -7.19300  50.97500  1.000 18.72932  ?  313 GLN   B N    1 
ATOM   3211 C  CA   . GLN   C 1 161 ? 38.62800  -8.25700  51.34400  1.000 19.17365  ?  313 GLN   B CA   1 
ATOM   3212 C  C    . GLN   C 1 161 ? 39.28600  -9.27400  52.26700  1.000 26.93151  ?  313 GLN   B C    1 
ATOM   3213 O  O    . GLN   C 1 161 ? 38.65600  -9.76900  53.21000  1.000 17.01484  ?  313 GLN   B O    1 
ATOM   3214 C  CB   . GLN   C 1 161 ? 38.09000  -8.95400  50.09500  1.000 18.00180  ?  313 GLN   B CB   1 
ATOM   3215 C  CG   . GLN   C 1 161 ? 37.33300  -8.05300  49.12200  1.000 27.93007  ?  313 GLN   B CG   1 
ATOM   3216 C  CD   . GLN   C 1 161 ? 36.00200  -7.57400  49.67100  1.000 23.35936  ?  313 GLN   B CD   1 
ATOM   3217 O  OE1  . GLN   C 1 161 ? 35.39700  -8.22700  50.51900  1.000 26.03321  ?  313 GLN   B OE1  1 
ATOM   3218 N  NE2  . GLN   C 1 161 ? 35.53500  -6.43100  49.17700  1.000 20.87697  ?  313 GLN   B NE2  1 
ATOM   3219 N  N    . VAL   C 1 162 ? 40.55000  -9.61100  52.00300  1.000 20.15900  ?  314 VAL   B N    1 
ATOM   3220 C  CA   . VAL   C 1 162 ? 41.24600  -10.58600 52.83700  1.000 24.14929  ?  314 VAL   B CA   1 
ATOM   3221 C  C    . VAL   C 1 162 ? 41.44400  -10.03700 54.24200  1.000 17.13018  ?  314 VAL   B C    1 
ATOM   3222 O  O    . VAL   C 1 162 ? 41.15500  -10.71200 55.23700  1.000 25.17560  ?  314 VAL   B O    1 
ATOM   3223 C  CB   . VAL   C 1 162 ? 42.58500  -10.98300 52.19200  1.000 24.30959  ?  314 VAL   B CB   1 
ATOM   3224 C  CG1  . VAL   C 1 162 ? 43.43000  -11.79400 53.17100  1.000 22.85595  ?  314 VAL   B CG1  1 
ATOM   3225 C  CG2  . VAL   C 1 162 ? 42.33200  -11.76600 50.91900  1.000 23.67464  ?  314 VAL   B CG2  1 
ATOM   3226 N  N    . GLY   C 1 163 ? 41.94100  -8.80200  54.34300  1.000 24.18114  ?  315 GLY   B N    1 
ATOM   3227 C  CA   . GLY   C 1 163 ? 42.17500  -8.21300  55.65100  1.000 25.16207  ?  315 GLY   B CA   1 
ATOM   3228 C  C    . GLY   C 1 163 ? 40.89700  -8.02400  56.44400  1.000 29.88620  ?  315 GLY   B C    1 
ATOM   3229 O  O    . GLY   C 1 163 ? 40.88000  -8.20000  57.66500  1.000 21.83721  ?  315 GLY   B O    1 
ATOM   3230 N  N    . LEU   C 1 164 ? 39.80900  -7.65300  55.76400  1.000 21.68054  ?  316 LEU   B N    1 
ATOM   3231 C  CA   . LEU   C 1 164 ? 38.52000  -7.54800  56.43900  1.000 22.98688  ?  316 LEU   B CA   1 
ATOM   3232 C  C    . LEU   C 1 164 ? 38.04200  -8.91200  56.92000  1.000 22.49370  ?  316 LEU   B C    1 
ATOM   3233 O  O    . LEU   C 1 164 ? 37.55600  -9.04400  58.05000  1.000 25.36632  ?  316 LEU   B O    1 
ATOM   3234 C  CB   . LEU   C 1 164 ? 37.49100  -6.91000  55.50300  1.000 19.55357  ?  316 LEU   B CB   1 
ATOM   3235 C  CG   . LEU   C 1 164 ? 36.11100  -6.57200  56.08000  1.000 23.08967  ?  316 LEU   B CG   1 
ATOM   3236 C  CD1  . LEU   C 1 164 ? 36.21600  -5.70400  57.32100  1.000 20.54950  ?  316 LEU   B CD1  1 
ATOM   3237 C  CD2  . LEU   C 1 164 ? 35.24400  -5.89700  55.01900  1.000 23.26853  ?  316 LEU   B CD2  1 
ATOM   3238 N  N    . LYS   C 1 165 ? 38.18400  -9.94000  56.07900  1.000 24.03578  ?  317 LYS   B N    1 
ATOM   3239 C  CA   . LYS   C 1 165 ? 37.78800  -11.28800 56.47400  1.000 26.04089  ?  317 LYS   B CA   1 
ATOM   3240 C  C    . LYS   C 1 165 ? 38.56000  -11.75200 57.70100  1.000 31.47268  ?  317 LYS   B C    1 
ATOM   3241 O  O    . LYS   C 1 165 ? 38.00800  -12.43300 58.57400  1.000 30.59623  ?  317 LYS   B O    1 
ATOM   3242 C  CB   . LYS   C 1 165 ? 38.00700  -12.25900 55.31200  1.000 27.17418  ?  317 LYS   B CB   1 
ATOM   3243 C  CG   . LYS   C 1 165 ? 37.05000  -13.43600 55.29100  1.000 32.51060  ?  317 LYS   B CG   1 
ATOM   3244 C  CD   . LYS   C 1 165 ? 35.63400  -12.98000 54.98900  1.000 32.93814  ?  317 LYS   B CD   1 
ATOM   3245 C  CE   . LYS   C 1 165 ? 34.66900  -14.14700 54.96400  1.000 40.86479  ?  317 LYS   B CE   1 
ATOM   3246 N  NZ   . LYS   C 1 165 ? 33.34700  -13.73300 54.42800  1.000 33.44406  ?  317 LYS   B NZ   1 
ATOM   3247 N  N    . LYS   C 1 166 ? 39.83900  -11.38200 57.78900  1.000 27.95609  ?  318 LYS   B N    1 
ATOM   3248 C  CA   . LYS   C 1 166 ? 40.67800  -11.84000 58.88800  1.000 31.58289  ?  318 LYS   B CA   1 
ATOM   3249 C  C    . LYS   C 1 166 ? 40.30700  -11.19700 60.21800  1.000 35.76799  ?  318 LYS   B C    1 
ATOM   3250 O  O    . LYS   C 1 166 ? 40.67000  -11.73400 61.26900  1.000 24.88461  ?  318 LYS   B O    1 
ATOM   3251 C  CB   . LYS   C 1 166 ? 42.14800  -11.57400 58.56600  1.000 27.81467  ?  318 LYS   B CB   1 
ATOM   3252 C  CG   . LYS   C 1 166 ? 42.71200  -12.48500 57.48600  1.000 28.26881  ?  318 LYS   B CG   1 
ATOM   3253 C  CD   . LYS   C 1 166 ? 44.13000  -12.08300 57.10800  1.000 34.80693  ?  318 LYS   B CD   1 
ATOM   3254 C  CE   . LYS   C 1 166 ? 44.81400  -13.17300 56.30000  1.000 33.30077  ?  318 LYS   B CE   1 
ATOM   3255 N  NZ   . LYS   C 1 166 ? 46.06300  -12.67100 55.66700  1.000 41.20084  ?  318 LYS   B NZ   1 
ATOM   3256 N  N    . LEU   C 1 167 ? 39.60000  -10.06400 60.20300  1.000 28.49853  ?  319 LEU   B N    1 
ATOM   3257 C  CA   . LEU   C 1 167 ? 39.12900  -9.47000  61.45000  1.000 25.80632  ?  319 LEU   B CA   1 
ATOM   3258 C  C    . LEU   C 1 167 ? 38.05300  -10.31600 62.11800  1.000 19.27846  ?  319 LEU   B C    1 
ATOM   3259 O  O    . LEU   C 1 167 ? 37.80100  -10.14100 63.31500  1.000 27.90971  ?  319 LEU   B O    1 
ATOM   3260 C  CB   . LEU   C 1 167 ? 38.59000  -8.05900  61.20400  1.000 18.25427  ?  319 LEU   B CB   1 
ATOM   3261 C  CG   . LEU   C 1 167 ? 39.58600  -6.97400  60.79500  1.000 26.32379  ?  319 LEU   B CG   1 
ATOM   3262 C  CD1  . LEU   C 1 167 ? 38.91500  -5.60800  60.81800  1.000 22.98397  ?  319 LEU   B CD1  1 
ATOM   3263 C  CD2  . LEU   C 1 167 ? 40.80600  -6.99000  61.70500  1.000 31.86484  ?  319 LEU   B CD2  1 
ATOM   3264 N  N    . ASN   C 1 168 ? 37.41500  -11.21600 61.37100  1.000 15.24924  ?  320 ASN   B N    1 
ATOM   3265 C  CA   . ASN   C 1 168 ? 36.39100  -12.11500 61.90100  1.000 29.65805  ?  320 ASN   B CA   1 
ATOM   3266 C  C    . ASN   C 1 168 ? 35.30600  -11.33900 62.64900  1.000 25.97985  ?  320 ASN   B C    1 
ATOM   3267 O  O    . ASN   C 1 168 ? 34.94200  -11.65900 63.78300  1.000 28.77285  ?  320 ASN   B O    1 
ATOM   3268 C  CB   . ASN   C 1 168 ? 37.02500  -13.18400 62.79300  1.000 35.00292  ?  320 ASN   B CB   1 
ATOM   3269 C  CG   . ASN   C 1 168 ? 36.19200  -14.44800 62.86600  1.000 48.79576  ?  320 ASN   B CG   1 
ATOM   3270 O  OD1  . ASN   C 1 168 ? 35.29800  -14.66600 62.04700  1.000 59.54065  ?  320 ASN   B OD1  1 
ATOM   3271 N  ND2  . ASN   C 1 168 ? 36.48400  -15.29200 63.84800  1.000 63.98263  ?  320 ASN   B ND2  1 
ATOM   3272 N  N    . LEU   C 1 169 ? 34.78200  -10.30400 61.99200  1.000 21.65502  ?  321 LEU   B N    1 
ATOM   3273 C  CA   . LEU   C 1 169 ? 33.82300  -9.41500  62.63400  1.000 17.70117  ?  321 LEU   B CA   1 
ATOM   3274 C  C    . LEU   C 1 169 ? 32.52500  -10.14200 62.96000  1.000 17.63488  ?  321 LEU   B C    1 
ATOM   3275 O  O    . LEU   C 1 169 ? 32.06800  -11.00900 62.21000  1.000 23.15595  ?  321 LEU   B O    1 
ATOM   3276 C  CB   . LEU   C 1 169 ? 33.51800  -8.21600  61.73600  1.000 15.18036  ?  321 LEU   B CB   1 
ATOM   3277 C  CG   . LEU   C 1 169 ? 34.62900  -7.21400  61.41200  1.000 24.94152  ?  321 LEU   B CG   1 
ATOM   3278 C  CD1  . LEU   C 1 169 ? 34.03800  -5.98100  60.73200  1.000 24.88451  ?  321 LEU   B CD1  1 
ATOM   3279 C  CD2  . LEU   C 1 169 ? 35.39800  -6.82600  62.66300  1.000 21.64412  ?  321 LEU   B CD2  1 
ATOM   3280 N  N    . HIS   C 1 170 ? 31.93200  -9.78600  64.09500  1.000 21.09504  ?  322 HIS   B N    1 
ATOM   3281 C  CA   . HIS   C 1 170 ? 30.56100  -10.17500 64.36100  1.000 18.45972  ?  322 HIS   B CA   1 
ATOM   3282 C  C    . HIS   C 1 170 ? 29.63000  -9.37600  63.45500  1.000 21.28389  ?  322 HIS   B C    1 
ATOM   3283 O  O    . HIS   C 1 170 ? 29.98300  -8.30300  62.96100  1.000 18.50235  ?  322 HIS   B O    1 
ATOM   3284 C  CB   . HIS   C 1 170 ? 30.19600  -9.93000  65.82600  1.000 23.26165  ?  322 HIS   B CB   1 
ATOM   3285 C  CG   . HIS   C 1 170 ? 31.09600  -10.62000 66.80600  1.000 29.97349  ?  322 HIS   B CG   1 
ATOM   3286 N  ND1  . HIS   C 1 170 ? 30.75300  -10.79500 68.13000  1.000 41.70042  ?  322 HIS   B ND1  1 
ATOM   3287 C  CD2  . HIS   C 1 170 ? 32.32400  -11.17400 66.66000  1.000 33.95550  ?  322 HIS   B CD2  1 
ATOM   3288 C  CE1  . HIS   C 1 170 ? 31.73000  -11.42700 68.75600  1.000 42.75741  ?  322 HIS   B CE1  1 
ATOM   3289 N  NE2  . HIS   C 1 170 ? 32.69500  -11.66900 67.88700  1.000 43.24432  ?  322 HIS   B NE2  1 
ATOM   3290 N  N    . GLU   C 1 171 ? 28.42700  -9.91400  63.23200  1.000 19.43200  ?  323 GLU   B N    1 
ATOM   3291 C  CA   . GLU   C 1 171 ? 27.44900  -9.19300  62.42000  1.000 21.27357  ?  323 GLU   B CA   1 
ATOM   3292 C  C    . GLU   C 1 171 ? 27.16600  -7.81300  63.00100  1.000 19.50645  ?  323 GLU   B C    1 
ATOM   3293 O  O    . GLU   C 1 171 ? 26.95700  -6.85000  62.25500  1.000 18.49447  ?  323 GLU   B O    1 
ATOM   3294 C  CB   . GLU   C 1 171 ? 26.15400  -10.00000 62.29500  1.000 25.56639  ?  323 GLU   B CB   1 
ATOM   3295 C  CG   . GLU   C 1 171 ? 25.29700  -9.59900  61.10000  1.000 27.54350  ?  323 GLU   B CG   1 
ATOM   3296 C  CD   . GLU   C 1 171 ? 24.00800  -10.39900 60.99900  1.000 37.94461  ?  323 GLU   B CD   1 
ATOM   3297 O  OE1  . GLU   C 1 171 ? 23.51300  -10.87400 62.04100  1.000 39.42881  ?  323 GLU   B OE1  1 
ATOM   3298 O  OE2  . GLU   C 1 171 ? 23.49100  -10.54900 59.87500  1.000 41.00850  ?  323 GLU   B OE2  1 
ATOM   3299 N  N    . GLU   C 1 172 ? 27.17500  -7.69700  64.33300  1.000 15.64759  ?  324 GLU   B N    1 
ATOM   3300 C  CA   . GLU   C 1 172 ? 26.97000  -6.40200  64.97600  1.000 16.37962  ?  324 GLU   B CA   1 
ATOM   3301 C  C    . GLU   C 1 172 ? 28.04100  -5.40000  64.56100  1.000 21.27511  ?  324 GLU   B C    1 
ATOM   3302 O  O    . GLU   C 1 172 ? 27.73500  -4.24000  64.26300  1.000 13.57502  ?  324 GLU   B O    1 
ATOM   3303 C  CB   . GLU   C 1 172 ? 26.96200  -6.56900  66.49800  1.000 15.13012  ?  324 GLU   B CB   1 
ATOM   3304 C  CG   . GLU   C 1 172 ? 25.76900  -7.32500  67.04800  1.000 16.54181  ?  324 GLU   B CG   1 
ATOM   3305 C  CD   . GLU   C 1 172 ? 25.96100  -8.82800  67.03100  1.000 25.45358  ?  324 GLU   B CD   1 
ATOM   3306 O  OE1  . GLU   C 1 172 ? 25.18400  -9.53200  67.70900  1.000 30.42580  ?  324 GLU   B OE1  1 
ATOM   3307 O  OE2  . GLU   C 1 172 ? 26.88300  -9.30900  66.34100  1.000 23.08141  ?  324 GLU   B OE2  1 
ATOM   3308 N  N    . GLU   C 1 173 ? 29.30400  -5.82600  64.54400  1.000 15.80319  ?  325 GLU   B N    1 
ATOM   3309 C  CA   . GLU   C 1 173 ? 30.38000  -4.93100  64.13400  1.000 15.84692  ?  325 GLU   B CA   1 
ATOM   3310 C  C    . GLU   C 1 173 ? 30.30900  -4.62900  62.64300  1.000 20.90549  ?  325 GLU   B C    1 
ATOM   3311 O  O    . GLU   C 1 173 ? 30.64800  -3.51900  62.21600  1.000 16.41753  ?  325 GLU   B O    1 
ATOM   3312 C  CB   . GLU   C 1 173 ? 31.73400  -5.54700  64.49900  1.000 16.60310  ?  325 GLU   B CB   1 
ATOM   3313 C  CG   . GLU   C 1 173 ? 31.95700  -5.66900  66.00600  1.000 17.73651  ?  325 GLU   B CG   1 
ATOM   3314 C  CD   . GLU   C 1 173 ? 32.93400  -6.77000  66.38000  1.000 22.59112  ?  325 GLU   B CD   1 
ATOM   3315 O  OE1  . GLU   C 1 173 ? 33.46000  -6.73600  67.51300  1.000 20.60452  ?  325 GLU   B OE1  1 
ATOM   3316 O  OE2  . GLU   C 1 173 ? 33.17200  -7.66900  65.54700  1.000 23.44784  ?  325 GLU   B OE2  1 
ATOM   3317 N  N    . HIS   C 1 174 ? 29.85200  -5.59800  61.84600  1.000 13.66427  ?  326 HIS   B N    1 
ATOM   3318 C  CA   . HIS   C 1 174 ? 29.71800  -5.40200  60.40600  1.000 14.06667  ?  326 HIS   B CA   1 
ATOM   3319 C  C    . HIS   C 1 174 ? 28.68400  -4.32400  60.08300  1.000 18.43469  ?  326 HIS   B C    1 
ATOM   3320 O  O    . HIS   C 1 174 ? 28.95000  -3.42100  59.28400  1.000 14.52129  ?  326 HIS   B O    1 
ATOM   3321 C  CB   . HIS   C 1 174 ? 29.35500  -6.73800  59.74800  1.000 14.74533  ?  326 HIS   B CB   1 
ATOM   3322 C  CG   . HIS   C 1 174 ? 29.21000  -6.67600  58.25800  1.000 21.56841  ?  326 HIS   B CG   1 
ATOM   3323 N  ND1  . HIS   C 1 174 ? 30.26100  -6.37900  57.41500  1.000 27.07450  ?  326 HIS   B ND1  1 
ATOM   3324 C  CD2  . HIS   C 1 174 ? 28.14000  -6.90100  57.45800  1.000 22.13433  ?  326 HIS   B CD2  1 
ATOM   3325 C  CE1  . HIS   C 1 174 ? 29.84000  -6.41000  56.16300  1.000 24.55484  ?  326 HIS   B CE1  1 
ATOM   3326 N  NE2  . HIS   C 1 174 ? 28.55800  -6.72700  56.16200  1.000 17.13080  ?  326 HIS   B NE2  1 
ATOM   3327 N  N    . VAL   C 1 175 ? 27.49900  -4.39300  60.70100  1.000 17.05103  ?  327 VAL   B N    1 
ATOM   3328 C  CA   . VAL   C 1 175 ? 26.45400  -3.42200  60.36500  1.000 16.48105  ?  327 VAL   B CA   1 
ATOM   3329 C  C    . VAL   C 1 175 ? 26.78800  -2.04300  60.91800  1.000 17.52997  ?  327 VAL   B C    1 
ATOM   3330 O  O    . VAL   C 1 175 ? 26.44200  -1.02200  60.30900  1.000 14.91418  ?  327 VAL   B O    1 
ATOM   3331 C  CB   . VAL   C 1 175 ? 25.06700  -3.88900  60.85100  1.000 17.51914  ?  327 VAL   B CB   1 
ATOM   3332 C  CG1  . VAL   C 1 175 ? 24.65400  -5.17200  60.13600  1.000 13.22739  ?  327 VAL   B CG1  1 
ATOM   3333 C  CG2  . VAL   C 1 175 ? 25.03100  -4.05600  62.37900  1.000 16.55901  ?  327 VAL   B CG2  1 
ATOM   3334 N  N    . LEU   C 1 176 ? 27.44800  -1.97700  62.07500  1.000 12.52750  ?  328 LEU   B N    1 
ATOM   3335 C  CA   . LEU   C 1 176 ? 27.86900  -0.68100  62.59200  1.000 14.95949  ?  328 LEU   B CA   1 
ATOM   3336 C  C    . LEU   C 1 176 ? 28.88000  -0.02400  61.65900  1.000 12.94907  ?  328 LEU   B C    1 
ATOM   3337 O  O    . LEU   C 1 176 ? 28.81500  1.18600   61.41700  1.000 16.73195  ?  328 LEU   B O    1 
ATOM   3338 C  CB   . LEU   C 1 176 ? 28.44600  -0.83800  64.00000  1.000 11.72092  ?  328 LEU   B CB   1 
ATOM   3339 C  CG   . LEU   C 1 176 ? 27.38200  -0.94700  65.09700  1.000 16.03069  ?  328 LEU   B CG   1 
ATOM   3340 C  CD1  . LEU   C 1 176 ? 27.95300  -1.56300  66.36800  1.000 15.23265  ?  328 LEU   B CD1  1 
ATOM   3341 C  CD2  . LEU   C 1 176 ? 26.76700  0.42200   65.38700  1.000 14.42172  ?  328 LEU   B CD2  1 
ATOM   3342 N  N    . LEU   C 1 177 ? 29.80600  -0.81300  61.10400  1.000 15.67990  ?  329 LEU   B N    1 
ATOM   3343 C  CA   . LEU   C 1 177 ? 30.80300  -0.26300  60.18700  1.000 15.18951  ?  329 LEU   B CA   1 
ATOM   3344 C  C    . LEU   C 1 177 ? 30.15700  0.27800   58.91500  1.000 14.70769  ?  329 LEU   B C    1 
ATOM   3345 O  O    . LEU   C 1 177 ? 30.53400  1.35000   58.42700  1.000 15.55660  ?  329 LEU   B O    1 
ATOM   3346 C  CB   . LEU   C 1 177 ? 31.84200  -1.33100  59.84000  1.000 19.07182  ?  329 LEU   B CB   1 
ATOM   3347 C  CG   . LEU   C 1 177 ? 33.15600  -0.85000  59.21800  1.000 23.27628  ?  329 LEU   B CG   1 
ATOM   3348 C  CD1  . LEU   C 1 177 ? 33.82100  0.21200   60.08600  1.000 21.59039  ?  329 LEU   B CD1  1 
ATOM   3349 C  CD2  . LEU   C 1 177 ? 34.09800  -2.02600  58.98000  1.000 22.57492  ?  329 LEU   B CD2  1 
ATOM   3350 N  N    . MET   C 1 178 ? 29.19700  -0.45700  58.34900  1.000 12.71829  ?  330 MET   B N    1 
ATOM   3351 C  CA   . MET   C 1 178 ? 28.50300  0.05000   57.16800  1.000 11.86417  ?  330 MET   B CA   1 
ATOM   3352 C  C    . MET   C 1 178 ? 27.77300  1.35100   57.48100  1.000 12.03070  ?  330 MET   B C    1 
ATOM   3353 O  O    . MET   C 1 178 ? 27.82800  2.30700   56.70000  1.000 16.26424  ?  330 MET   B O    1 
ATOM   3354 C  CB   . MET   C 1 178 ? 27.52700  -1.00100  56.63000  1.000 11.19615  ?  330 MET   B CB   1 
ATOM   3355 C  CG   . MET   C 1 178 ? 28.20500  -2.21800  56.00200  1.000 16.30364  ?  330 MET   B CG   1 
ATOM   3356 S  SD   . MET   C 1 178 ? 27.06400  -3.26500  55.06800  1.000 21.24962  ?  330 MET   B SD   1 
ATOM   3357 C  CE   . MET   C 1 178 ? 25.97000  -3.80000  56.37700  1.000 19.49484  ?  330 MET   B CE   1 
ATOM   3358 N  N    . ALA   C 1 179 ? 27.10200  1.41200   58.63300  1.000 10.13790  ?  331 ALA   B N    1 
ATOM   3359 C  CA   . ALA   C 1 179 ? 26.37900  2.62300   59.01500  1.000 12.03381  ?  331 ALA   B CA   1 
ATOM   3360 C  C    . ALA   C 1 179 ? 27.33300  3.79000   59.24900  1.000 11.51469  ?  331 ALA   B C    1 
ATOM   3361 O  O    . ALA   C 1 179 ? 27.07800  4.91300   58.79600  1.000 14.88808  ?  331 ALA   B O    1 
ATOM   3362 C  CB   . ALA   C 1 179 ? 25.54100  2.36100   60.26600  1.000 12.22541  ?  331 ALA   B CB   1 
ATOM   3363 N  N    . ILE   C 1 180 ? 28.43000  3.54900   59.97100  1.000 11.25860  ?  332 ILE   B N    1 
ATOM   3364 C  CA   . ILE   C 1 180 ? 29.41100  4.60900   60.20500  1.000 12.09640  ?  332 ILE   B CA   1 
ATOM   3365 C  C    . ILE   C 1 180 ? 29.97600  5.10700   58.88100  1.000 17.14484  ?  332 ILE   B C    1 
ATOM   3366 O  O    . ILE   C 1 180 ? 30.23000  6.30800   58.70100  1.000 14.46360  ?  332 ILE   B O    1 
ATOM   3367 C  CB   . ILE   C 1 180 ? 30.52500  4.10400   61.14500  1.000 18.17453  ?  332 ILE   B CB   1 
ATOM   3368 C  CG1  . ILE   C 1 180 ? 29.96500  3.85200   62.54800  1.000 15.91812  ?  332 ILE   B CG1  1 
ATOM   3369 C  CG2  . ILE   C 1 180 ? 31.67900  5.08700   61.20200  1.000 16.38398  ?  332 ILE   B CG2  1 
ATOM   3370 C  CD1  . ILE   C 1 180 ? 30.88300  3.02300   63.43300  1.000 17.76907  ?  332 ILE   B CD1  1 
ATOM   3371 N  N    . CYS   C 1 181 ? 30.16400  4.19600   57.92500  1.000 12.62961  ?  333 CYS   B N    1 
ATOM   3372 C  CA   . CYS   C 1 181 ? 30.74400  4.59600   56.65300  1.000 17.23219  ?  333 CYS   B CA   1 
ATOM   3373 C  C    . CYS   C 1 181 ? 29.77500  5.50500   55.90100  1.000 17.64549  ?  333 CYS   B C    1 
ATOM   3374 O  O    . CYS   C 1 181 ? 30.18500  6.50000   55.29600  1.000 14.49200  ?  333 CYS   B O    1 
ATOM   3375 C  CB   . CYS   C 1 181 ? 31.12500  3.34400   55.84800  1.000 17.75833  ?  333 CYS   B CB   1 
ATOM   3376 S  SG   . CYS   C 1 181 ? 31.54800  3.55900   54.10900  1.000 18.82343  ?  333 CYS   B SG   1 
ATOM   3377 N  N    . ILE   C 1 182 ? 28.47400  5.23800   56.02800  1.000 14.37414  ?  334 ILE   B N    1 
ATOM   3378 C  CA   . ILE   C 1 182 ? 27.45400  6.03200   55.33400  1.000 16.25055  ?  334 ILE   B CA   1 
ATOM   3379 C  C    . ILE   C 1 182 ? 27.32800  7.42700   55.93400  1.000 16.36771  ?  334 ILE   B C    1 
ATOM   3380 O  O    . ILE   C 1 182 ? 27.35500  8.43500   55.21500  1.000 17.92739  ?  334 ILE   B O    1 
ATOM   3381 C  CB   . ILE   C 1 182 ? 26.10100  5.29900   55.36000  1.000 13.24296  ?  334 ILE   B CB   1 
ATOM   3382 C  CG1  . ILE   C 1 182 ? 26.14100  4.08100   54.42100  1.000 10.55739  ?  334 ILE   B CG1  1 
ATOM   3383 C  CG2  . ILE   C 1 182 ? 24.96300  6.22300   54.96600  1.000 14.57358  ?  334 ILE   B CG2  1 
ATOM   3384 C  CD1  . ILE   C 1 182 ? 25.02500  3.05600   54.65800  1.000 11.10293  ?  334 ILE   B CD1  1 
ATOM   3385 N  N    A VAL   C 1 183 ? 27.19400  7.50500   57.25500  0.580 12.27062  ?  335 VAL   B N    1 
ATOM   3386 N  N    B VAL   C 1 183 ? 27.19500  7.52100   57.25600  0.420 12.31493  ?  335 VAL   B N    1 
ATOM   3387 C  CA   A VAL   C 1 183 ? 26.99300  8.77700   57.93600  0.580 16.09745  ?  335 VAL   B CA   1 
ATOM   3388 C  CA   B VAL   C 1 183 ? 27.00500  8.83300   57.86900  0.420 16.13251  ?  335 VAL   B CA   1 
ATOM   3389 C  C    A VAL   C 1 183 ? 28.35300  9.37800   58.26400  0.580 17.54210  ?  335 VAL   B C    1 
ATOM   3390 C  C    B VAL   C 1 183 ? 28.35700  9.44800   58.21800  0.420 17.52045  ?  335 VAL   B C    1 
ATOM   3391 O  O    A VAL   C 1 183 ? 28.75800  9.42600   59.42900  0.580 20.49947  ?  335 VAL   B O    1 
ATOM   3392 O  O    B VAL   C 1 183 ? 28.69700  9.62000   59.39300  0.420 20.44363  ?  335 VAL   B O    1 
ATOM   3393 C  CB   A VAL   C 1 183 ? 26.12500  8.59500   59.19700  0.580 17.60686  ?  335 VAL   B CB   1 
ATOM   3394 C  CB   B VAL   C 1 183 ? 26.07800  8.76200   59.10000  0.420 17.47709  ?  335 VAL   B CB   1 
ATOM   3395 C  CG1  A VAL   C 1 183 ? 25.70300  9.93700   59.76700  0.580 13.88256  ?  335 VAL   B CG1  1 
ATOM   3396 C  CG1  B VAL   C 1 183 ? 24.65300  8.46300   58.66300  0.420 16.67115  ?  335 VAL   B CG1  1 
ATOM   3397 C  CG2  A VAL   C 1 183 ? 24.90200  7.74900   58.86900  0.580 16.40304  ?  335 VAL   B CG2  1 
ATOM   3398 C  CG2  B VAL   C 1 183 ? 26.55400  7.71300   60.08400  0.420 15.56146  ?  335 VAL   B CG2  1 
ATOM   3399 N  N    A SER   C 1 184 ? 29.07000  9.82700   57.23200  0.580 17.37311  ?  336 SER   B N    1 
ATOM   3400 N  N    B SER   C 1 184 ? 29.13000  9.80600   57.19300  0.420 17.41476  ?  336 SER   B N    1 
ATOM   3401 C  CA   A SER   C 1 184 ? 30.38400  10.43800  57.38500  0.580 20.05727  ?  336 SER   B CA   1 
ATOM   3402 C  CA   B SER   C 1 184 ? 30.42300  10.43800  57.39900  0.420 20.02453  ?  336 SER   B CA   1 
ATOM   3403 C  C    A SER   C 1 184 ? 30.26200  11.94200  57.21100  0.580 16.35135  ?  336 SER   B C    1 
ATOM   3404 C  C    B SER   C 1 184 ? 30.29200  11.93800  57.20500  0.420 16.41400  ?  336 SER   B C    1 
ATOM   3405 O  O    A SER   C 1 184 ? 29.83200  12.39400  56.14000  0.580 17.29582  ?  336 SER   B O    1 
ATOM   3406 O  O    B SER   C 1 184 ? 29.88100  12.37800  56.12000  0.420 17.27678  ?  336 SER   B O    1 
ATOM   3407 C  CB   A SER   C 1 184 ? 31.36900  9.86600   56.36500  0.580 21.44495  ?  336 SER   B CB   1 
ATOM   3408 C  CB   B SER   C 1 184 ? 31.45600  9.87000   56.43400  0.420 21.44126  ?  336 SER   B CB   1 
ATOM   3409 O  OG   A SER   C 1 184 ? 31.56500  8.47300   56.54600  0.580 22.58034  ?  336 SER   B OG   1 
ATOM   3410 O  OG   B SER   C 1 184 ? 32.75000  10.36300  56.73200  0.420 21.64467  ?  336 SER   B OG   1 
ATOM   3411 N  N    . PRO   C 1 185 ? 30.62800  12.75600  58.20800  1.000 16.70118  ?  337 PRO   B N    1 
ATOM   3412 C  CA   . PRO   C 1 185 ? 30.47600  14.21200  58.05900  1.000 13.83160  ?  337 PRO   B CA   1 
ATOM   3413 C  C    . PRO   C 1 185 ? 31.48400  14.84700  57.12000  1.000 20.24453  ?  337 PRO   B C    1 
ATOM   3414 O  O    . PRO   C 1 185 ? 31.30900  16.01800  56.76000  1.000 21.67193  ?  337 PRO   B O    1 
ATOM   3415 C  CB   . PRO   C 1 185 ? 30.66000  14.72600  59.49200  1.000 24.01965  ?  337 PRO   B CB   1 
ATOM   3416 C  CG   . PRO   C 1 185 ? 31.56300  13.71500  60.12400  1.000 23.14701  ?  337 PRO   B CG   1 
ATOM   3417 C  CD   . PRO   C 1 185 ? 31.16100  12.38400  59.53000  1.000 18.27426  ?  337 PRO   B CD   1 
ATOM   3418 N  N    . ASP   C 1 186 ? 32.52100  14.12500  56.69600  1.000 14.74295  ?  338 ASP   B N    1 
ATOM   3419 C  CA   . ASP   C 1 186 ? 33.56800  14.70400  55.86200  1.000 23.93516  ?  338 ASP   B CA   1 
ATOM   3420 C  C    . ASP   C 1 186 ? 33.41300  14.33600  54.38700  1.000 26.20814  ?  338 ASP   B C    1 
ATOM   3421 O  O    . ASP   C 1 186 ? 34.40400  14.26700  53.65400  1.000 42.47962  ?  338 ASP   B O    1 
ATOM   3422 C  CB   . ASP   C 1 186 ? 34.95000  14.30200  56.38200  1.000 24.12442  ?  338 ASP   B CB   1 
ATOM   3423 C  CG   . ASP   C 1 186 ? 35.25800  12.84200  56.16400  1.000 37.02476  ?  338 ASP   B CG   1 
ATOM   3424 O  OD1  . ASP   C 1 186 ? 36.39500  12.53800  55.74000  1.000 45.80447  ?  338 ASP   B OD1  1 
ATOM   3425 O  OD2  . ASP   C 1 186 ? 34.37400  11.99700  56.42300  1.000 37.58489  ?  338 ASP   B OD2  1 
ATOM   3426 N  N    . ARG   C 1 187 ? 32.18300  14.11000  53.93800  1.000 23.56246  ?  339 ARG   B N    1 
ATOM   3427 C  CA   . ARG   C 1 187 ? 31.96600  13.94500  52.50600  1.000 16.62071  ?  339 ARG   B CA   1 
ATOM   3428 C  C    . ARG   C 1 187 ? 31.75700  15.31100  51.85500  1.000 23.38611  ?  339 ARG   B C    1 
ATOM   3429 O  O    . ARG   C 1 187 ? 31.11300  16.18300  52.44300  1.000 22.74214  ?  339 ARG   B O    1 
ATOM   3430 C  CB   . ARG   C 1 187 ? 30.74500  13.07000  52.24400  1.000 17.62298  ?  339 ARG   B CB   1 
ATOM   3431 C  CG   . ARG   C 1 187 ? 30.76500  11.73000  52.95500  1.000 19.07136  ?  339 ARG   B CG   1 
ATOM   3432 C  CD   . ARG   C 1 187 ? 31.77300  10.76800  52.33500  1.000 18.70347  ?  339 ARG   B CD   1 
ATOM   3433 N  NE   . ARG   C 1 187 ? 31.49200  9.38800   52.72400  1.000 18.40464  ?  339 ARG   B NE   1 
ATOM   3434 C  CZ   . ARG   C 1 187 ? 32.23000  8.34200   52.36900  1.000 20.44327  ?  339 ARG   B CZ   1 
ATOM   3435 N  NH1  . ARG   C 1 187 ? 33.30100  8.51000   51.60300  1.000 19.64791  ?  339 ARG   B NH1  1 
ATOM   3436 N  NH2  . ARG   C 1 187 ? 31.89500  7.12400   52.77900  1.000 22.16317  ?  339 ARG   B NH2  1 
ATOM   3437 N  N    . PRO   C 1 188 ? 32.28100  15.53300  50.65100  1.000 25.80495  ?  340 PRO   B N    1 
ATOM   3438 C  CA   . PRO   C 1 188 ? 32.07300  16.83000  49.99600  1.000 28.34641  ?  340 PRO   B CA   1 
ATOM   3439 C  C    . PRO   C 1 188 ? 30.59900  17.05900  49.69900  1.000 24.00367  ?  340 PRO   B C    1 
ATOM   3440 O  O    . PRO   C 1 188 ? 29.87300  16.13800  49.31900  1.000 25.53962  ?  340 PRO   B O    1 
ATOM   3441 C  CB   . PRO   C 1 188 ? 32.90100  16.71600  48.71100  1.000 27.37186  ?  340 PRO   B CB   1 
ATOM   3442 C  CG   . PRO   C 1 188 ? 32.99900  15.25100  48.45300  1.000 42.25917  ?  340 PRO   B CG   1 
ATOM   3443 C  CD   . PRO   C 1 188 ? 33.05600  14.60400  49.81100  1.000 27.72533  ?  340 PRO   B CD   1 
ATOM   3444 N  N    . GLY   C 1 189 ? 30.15400  18.30000  49.89800  1.000 20.61502  ?  341 GLY   B N    1 
ATOM   3445 C  CA   . GLY   C 1 189 ? 28.77900  18.67000  49.64800  1.000 20.92957  ?  341 GLY   B CA   1 
ATOM   3446 C  C    . GLY   C 1 189 ? 27.85000  18.56600  50.83900  1.000 23.04571  ?  341 GLY   B C    1 
ATOM   3447 O  O    . GLY   C 1 189 ? 26.69900  19.01200  50.74500  1.000 25.16465  ?  341 GLY   B O    1 
ATOM   3448 N  N    . VAL   C 1 190 ? 28.30300  17.99500  51.95700  1.000 21.83686  ?  342 VAL   B N    1 
ATOM   3449 C  CA   . VAL   C 1 190 ? 27.45200  17.89400  53.13800  1.000 25.78976  ?  342 VAL   B CA   1 
ATOM   3450 C  C    . VAL   C 1 190 ? 27.20500  19.28700  53.70100  1.000 23.61857  ?  342 VAL   B C    1 
ATOM   3451 O  O    . VAL   C 1 190 ? 28.13900  20.07700  53.88400  1.000 27.74079  ?  342 VAL   B O    1 
ATOM   3452 C  CB   . VAL   C 1 190 ? 28.08500  16.97200  54.19000  1.000 24.73845  ?  342 VAL   B CB   1 
ATOM   3453 C  CG1  . VAL   C 1 190 ? 27.35900  17.11100  55.52700  1.000 26.24042  ?  342 VAL   B CG1  1 
ATOM   3454 C  CG2  . VAL   C 1 190 ? 28.04700  15.52900  53.71800  1.000 24.09895  ?  342 VAL   B CG2  1 
ATOM   3455 N  N    . GLN   C 1 191 ? 25.94000  19.59900  53.97200  1.000 15.61438  ?  343 GLN   B N    1 
ATOM   3456 C  CA   . GLN   C 1 191 ? 25.59500  20.91800  54.48500  1.000 31.28170  ?  343 GLN   B CA   1 
ATOM   3457 C  C    . GLN   C 1 191 ? 25.51800  20.94000  56.00900  1.000 27.49530  ?  343 GLN   B C    1 
ATOM   3458 O  O    . GLN   C 1 191 ? 26.04400  21.86000  56.64500  1.000 39.82898  ?  343 GLN   B O    1 
ATOM   3459 C  CB   . GLN   C 1 191 ? 24.27000  21.38900  53.88100  1.000 33.33151  ?  343 GLN   B CB   1 
ATOM   3460 C  CG   . GLN   C 1 191 ? 24.36600  21.73000  52.40600  1.000 49.33122  ?  343 GLN   B CG   1 
ATOM   3461 C  CD   . GLN   C 1 191 ? 25.25200  22.93300  52.13700  1.000 64.60584  ?  343 GLN   B CD   1 
ATOM   3462 O  OE1  . GLN   C 1 191 ? 25.97600  22.97600  51.14100  1.000 58.79176  ?  343 GLN   B OE1  1 
ATOM   3463 N  NE2  . GLN   C 1 191 ? 25.19500  23.91900  53.02500  1.000 54.42692  ?  343 GLN   B NE2  1 
ATOM   3464 N  N    . ASP   C 1 192 ? 24.87300  19.94200  56.60700  1.000 21.49819  ?  344 ASP   B N    1 
ATOM   3465 C  CA   . ASP   C 1 192 ? 24.70300  19.88700  58.06000  1.000 20.74409  ?  344 ASP   B CA   1 
ATOM   3466 C  C    . ASP   C 1 192 ? 25.71200  18.91800  58.66900  1.000 16.05328  ?  344 ASP   B C    1 
ATOM   3467 O  O    . ASP   C 1 192 ? 25.36600  17.87400  59.22100  1.000 22.09345  ?  344 ASP   B O    1 
ATOM   3468 C  CB   . ASP   C 1 192 ? 23.27500  19.48700  58.40900  1.000 28.20954  ?  344 ASP   B CB   1 
ATOM   3469 C  CG   . ASP   C 1 192 ? 22.30100  20.60500  58.18600  1.000 35.61570  ?  344 ASP   B CG   1 
ATOM   3470 O  OD1  . ASP   C 1 192 ? 22.73700  21.76300  58.32300  1.000 47.68846  ?  344 ASP   B OD1  1 
ATOM   3471 O  OD2  . ASP   C 1 192 ? 21.12100  20.33700  57.88000  1.000 27.80669  ?  344 ASP   B OD2  1 
ATOM   3472 N  N    . ALA   C 1 193 ? 26.98700  19.30500  58.57500  1.000 20.00552  ?  345 ALA   B N    1 
ATOM   3473 C  CA   . ALA   C 1 193 ? 28.06600  18.42200  59.01200  1.000 20.40713  ?  345 ALA   B CA   1 
ATOM   3474 C  C    . ALA   C 1 193 ? 27.95100  18.06600  60.49000  1.000 19.33468  ?  345 ALA   B C    1 
ATOM   3475 O  O    . ALA   C 1 193 ? 28.26400  16.93400  60.88000  1.000 18.20098  ?  345 ALA   B O    1 
ATOM   3476 C  CB   . ALA   C 1 193 ? 29.42300  19.06600  58.72000  1.000 22.54938  ?  345 ALA   B CB   1 
ATOM   3477 N  N    . LYS   C 1 194 ? 27.49500  19.00300  61.32300  1.000 17.75413  ?  346 LYS   B N    1 
ATOM   3478 C  CA   . LYS   C 1 194 ? 27.39800  18.72200  62.75300  1.000 24.41253  ?  346 LYS   B CA   1 
ATOM   3479 C  C    . LYS   C 1 194 ? 26.26000  17.75900  63.07000  1.000 16.58347  ?  346 LYS   B C    1 
ATOM   3480 O  O    . LYS   C 1 194 ? 26.37400  16.96100  64.00600  1.000 18.88943  ?  346 LYS   B O    1 
ATOM   3481 C  CB   . LYS   C 1 194 ? 27.23100  20.02300  63.53700  1.000 26.43529  ?  346 LYS   B CB   1 
ATOM   3482 C  CG   . LYS   C 1 194 ? 28.44800  20.93200  63.45000  1.000 33.37334  ?  346 LYS   B CG   1 
ATOM   3483 C  CD   . LYS   C 1 194 ? 28.96200  21.31800  64.82500  1.000 52.82818  ?  346 LYS   B CD   1 
ATOM   3484 C  CE   . LYS   C 1 194 ? 30.30800  22.02900  64.73300  1.000 63.69022  ?  346 LYS   B CE   1 
ATOM   3485 N  NZ   . LYS   C 1 194 ? 31.45300  21.09600  64.95900  1.000 60.78086  ?  346 LYS   B NZ   1 
ATOM   3486 N  N    . LEU   C 1 195 ? 25.16500  17.81000  62.31200  1.000 14.72227  ?  347 LEU   B N    1 
ATOM   3487 C  CA   . LEU   C 1 195 ? 24.10700  16.81800  62.48300  1.000 17.78563  ?  347 LEU   B CA   1 
ATOM   3488 C  C    . LEU   C 1 195 ? 24.58800  15.43400  62.06700  1.000 17.18376  ?  347 LEU   B C    1 
ATOM   3489 O  O    . LEU   C 1 195 ? 24.36500  14.45000  62.77900  1.000 18.21565  ?  347 LEU   B O    1 
ATOM   3490 C  CB   . LEU   C 1 195 ? 22.86400  17.21900  61.68400  1.000 21.62893  ?  347 LEU   B CB   1 
ATOM   3491 C  CG   . LEU   C 1 195 ? 22.15200  18.49400  62.14500  1.000 28.18313  ?  347 LEU   B CG   1 
ATOM   3492 C  CD1  . LEU   C 1 195 ? 20.90600  18.75300  61.31600  1.000 25.34316  ?  347 LEU   B CD1  1 
ATOM   3493 C  CD2  . LEU   C 1 195 ? 21.81000  18.40100  63.62300  1.000 25.24526  ?  347 LEU   B CD2  1 
ATOM   3494 N  N    . VAL   C 1 196 ? 25.25500  15.34300  60.91100  1.000 13.83642  ?  348 VAL   B N    1 
ATOM   3495 C  CA   . VAL   C 1 196 ? 25.81600  14.06900  60.45900  1.000 17.06376  ?  348 VAL   B CA   1 
ATOM   3496 C  C    . VAL   C 1 196 ? 26.79800  13.52300  61.48900  1.000 18.29633  ?  348 VAL   B C    1 
ATOM   3497 O  O    . VAL   C 1 196 ? 26.79200  12.32700  61.81200  1.000 14.18750  ?  348 VAL   B O    1 
ATOM   3498 C  CB   . VAL   C 1 196 ? 26.48500  14.24800  59.08300  1.000 19.69474  ?  348 VAL   B CB   1 
ATOM   3499 C  CG1  . VAL   C 1 196 ? 27.16200  12.95800  58.64400  1.000 14.71766  ?  348 VAL   B CG1  1 
ATOM   3500 C  CG2  . VAL   C 1 196 ? 25.46800  14.71800  58.04900  1.000 14.28750  ?  348 VAL   B CG2  1 
ATOM   3501 N  N    . GLU   C 1 197 ? 27.66200  14.39200  62.01400  1.000 18.20575  ?  349 GLU   B N    1 
ATOM   3502 C  CA   . GLU   C 1 197 ? 28.63300  13.97200  63.01700  1.000 19.48277  ?  349 GLU   B CA   1 
ATOM   3503 C  C    . GLU   C 1 197 ? 27.94500  13.46100  64.27700  1.000 19.12235  ?  349 GLU   B C    1 
ATOM   3504 O  O    . GLU   C 1 197 ? 28.41200  12.50000  64.90000  1.000 23.19434  ?  349 GLU   B O    1 
ATOM   3505 C  CB   . GLU   C 1 197 ? 29.56000  15.14400  63.34300  1.000 23.51719  ?  349 GLU   B CB   1 
ATOM   3506 C  CG   . GLU   C 1 197 ? 30.63100  14.86000  64.37400  1.000 25.41800  ?  349 GLU   B CG   1 
ATOM   3507 C  CD   . GLU   C 1 197 ? 31.41400  16.11500  64.72300  1.000 28.52769  ?  349 GLU   B CD   1 
ATOM   3508 O  OE1  . GLU   C 1 197 ? 32.62900  16.15600  64.45100  1.000 40.29826  ?  349 GLU   B OE1  1 
ATOM   3509 O  OE2  . GLU   C 1 197 ? 30.80400  17.06500  65.25700  1.000 37.01235  ?  349 GLU   B OE2  1 
ATOM   3510 N  N    . ALA   C 1 198 ? 26.83100  14.08800  64.66400  1.000 17.59503  ?  350 ALA   B N    1 
ATOM   3511 C  CA   . ALA   C 1 198 ? 26.11500  13.65800  65.86300  1.000 27.10033  ?  350 ALA   B CA   1 
ATOM   3512 C  C    . ALA   C 1 198 ? 25.60100  12.23100  65.72200  1.000 22.29456  ?  350 ALA   B C    1 
ATOM   3513 O  O    . ALA   C 1 198 ? 25.66700  11.44300  66.67300  1.000 21.20885  ?  350 ALA   B O    1 
ATOM   3514 C  CB   . ALA   C 1 198 ? 24.96200  14.61600  66.16000  1.000 22.36826  ?  350 ALA   B CB   1 
ATOM   3515 N  N    . ILE   C 1 199 ? 25.08100  11.87900  64.54400  1.000 22.18812  ?  351 ILE   B N    1 
ATOM   3516 C  CA   . ILE   C 1 199 ? 24.65400  10.50300  64.30600  1.000 15.24360  ?  351 ILE   B CA   1 
ATOM   3517 C  C    . ILE   C 1 199 ? 25.85400  9.56700   64.33700  1.000 16.11462  ?  351 ILE   B C    1 
ATOM   3518 O  O    . ILE   C 1 199 ? 25.83900  8.53500   65.01900  1.000 15.31126  ?  351 ILE   B O    1 
ATOM   3519 C  CB   . ILE   C 1 199 ? 23.89500  10.39300  62.97100  1.000 17.40256  ?  351 ILE   B CB   1 
ATOM   3520 C  CG1  . ILE   C 1 199 ? 22.64900  11.28000  62.98400  1.000 19.56446  ?  351 ILE   B CG1  1 
ATOM   3521 C  CG2  . ILE   C 1 199 ? 23.51600  8.94500   62.68900  1.000 16.08809  ?  351 ILE   B CG2  1 
ATOM   3522 C  CD1  . ILE   C 1 199 ? 22.04600  11.47800  61.60400  1.000 17.39596  ?  351 ILE   B CD1  1 
ATOM   3523 N  N    . GLN   C 1 200 ? 26.91300  9.91300   63.59700  1.000 16.06391  ?  352 GLN   B N    1 
ATOM   3524 C  CA   . GLN   C 1 200 ? 28.07700  9.03200   63.51600  1.000 17.62801  ?  352 GLN   B CA   1 
ATOM   3525 C  C    . GLN   C 1 200 ? 28.70300  8.80900   64.88500  1.000 18.09036  ?  352 GLN   B C    1 
ATOM   3526 O  O    . GLN   C 1 200 ? 29.16600  7.70300   65.19100  1.000 17.06973  ?  352 GLN   B O    1 
ATOM   3527 C  CB   . GLN   C 1 200 ? 29.11900  9.60200   62.55600  1.000 14.27904  ?  352 GLN   B CB   1 
ATOM   3528 C  CG   . GLN   C 1 200 ? 30.12700  8.55800   62.08300  1.000 16.22957  ?  352 GLN   B CG   1 
ATOM   3529 C  CD   . GLN   C 1 200 ? 31.34800  9.16800   61.42500  1.000 18.42860  ?  352 GLN   B CD   1 
ATOM   3530 O  OE1  . GLN   C 1 200 ? 31.97800  10.07300  61.97400  1.000 19.10643  ?  352 GLN   B OE1  1 
ATOM   3531 N  NE2  . GLN   C 1 200 ? 31.69400  8.66500   60.23900  1.000 15.15499  ?  352 GLN   B NE2  1 
ATOM   3532 N  N    . ASP   C 1 201 ? 28.73700  9.85200   65.71800  1.000 15.28059  ?  353 ASP   B N    1 
ATOM   3533 C  CA   . ASP   C 1 201 ? 29.30100  9.70800   67.05700  1.000 20.44783  ?  353 ASP   B CA   1 
ATOM   3534 C  C    . ASP   C 1 201 ? 28.52300  8.69000   67.87700  1.000 20.47868  ?  353 ASP   B C    1 
ATOM   3535 O  O    . ASP   C 1 201 ? 29.11300  7.91400   68.63800  1.000 21.61207  ?  353 ASP   B O    1 
ATOM   3536 C  CB   . ASP   C 1 201 ? 29.32300  11.06300  67.76700  1.000 22.04915  ?  353 ASP   B CB   1 
ATOM   3537 C  CG   . ASP   C 1 201 ? 30.44700  11.95600  67.27900  1.000 25.89033  ?  353 ASP   B CG   1 
ATOM   3538 O  OD1  . ASP   C 1 201 ? 31.27700  11.48000  66.48000  1.000 26.18263  ?  353 ASP   B OD1  1 
ATOM   3539 O  OD2  . ASP   C 1 201 ? 30.49900  13.13200  67.69200  1.000 33.37863  ?  353 ASP   B OD2  1 
ATOM   3540 N  N    . ARG   C 1 202 ? 27.19600  8.67200   67.73400  1.000 18.48664  ?  354 ARG   B N    1 
ATOM   3541 C  CA   . ARG   C 1 202 ? 26.40100  7.68900   68.46000  1.000 23.09237  ?  354 ARG   B CA   1 
ATOM   3542 C  C    . ARG   C 1 202 ? 26.68200  6.27900   67.95900  1.000 22.05150  ?  354 ARG   B C    1 
ATOM   3543 O  O    . ARG   C 1 202 ? 26.69800  5.32700   68.74800  1.000 15.97772  ?  354 ARG   B O    1 
ATOM   3544 C  CB   . ARG   C 1 202 ? 24.91600  8.02700   68.34200  1.000 23.74942  ?  354 ARG   B CB   1 
ATOM   3545 C  CG   . ARG   C 1 202 ? 24.52800  9.28300   69.10600  1.000 31.88907  ?  354 ARG   B CG   1 
ATOM   3546 C  CD   . ARG   C 1 202 ? 23.03000  9.36300   69.33000  1.000 43.13334  ?  354 ARG   B CD   1 
ATOM   3547 N  NE   . ARG   C 1 202 ? 22.32700  9.84000   68.14400  1.000 41.18497  ?  354 ARG   B NE   1 
ATOM   3548 C  CZ   . ARG   C 1 202 ? 22.27400  11.11400  67.76800  1.000 52.27360  ?  354 ARG   B CZ   1 
ATOM   3549 N  NH1  . ARG   C 1 202 ? 22.88400  12.04900  68.48500  1.000 41.81659  ?  354 ARG   B NH1  1 
ATOM   3550 N  NH2  . ARG   C 1 202 ? 21.60900  11.45500  66.67200  1.000 44.77283  ?  354 ARG   B NH2  1 
ATOM   3551 N  N    . LEU   C 1 203 ? 26.91200  6.12700   66.65200  1.000 14.36465  ?  355 LEU   B N    1 
ATOM   3552 C  CA   . LEU   C 1 203 ? 27.24100  4.81400   66.11000  1.000 16.09698  ?  355 LEU   B CA   1 
ATOM   3553 C  C    . LEU   C 1 203 ? 28.64200  4.38200   66.52000  1.000 18.97387  ?  355 LEU   B C    1 
ATOM   3554 O  O    . LEU   C 1 203 ? 28.86800  3.20500   66.82600  1.000 13.32631  ?  355 LEU   B O    1 
ATOM   3555 C  CB   . LEU   C 1 203 ? 27.11100  4.82000   64.58700  1.000 12.35638  ?  355 LEU   B CB   1 
ATOM   3556 C  CG   . LEU   C 1 203 ? 25.74000  5.19400   64.02000  1.000 12.14828  ?  355 LEU   B CG   1 
ATOM   3557 C  CD1  . LEU   C 1 203 ? 25.85100  5.40600   62.53000  1.000 13.42071  ?  355 LEU   B CD1  1 
ATOM   3558 C  CD2  . LEU   C 1 203 ? 24.71600  4.11600   64.32300  1.000 17.41427  ?  355 LEU   B CD2  1 
ATOM   3559 N  N    A SER   C 1 204 ? 29.59700  5.31700   66.52800  0.610 14.66848  ?  356 SER   B N    1 
ATOM   3560 N  N    B SER   C 1 204 ? 29.59600  5.32000   66.52500  0.390 14.70589  ?  356 SER   B N    1 
ATOM   3561 C  CA   A SER   C 1 204 ? 30.96300  4.97000   66.90900  0.610 19.08359  ?  356 SER   B CA   1 
ATOM   3562 C  CA   B SER   C 1 204 ? 30.96400  4.98700   66.90900  0.390 19.05374  ?  356 SER   B CA   1 
ATOM   3563 C  C    A SER   C 1 204 ? 31.04500  4.58400   68.38000  0.610 17.24294  ?  356 SER   B C    1 
ATOM   3564 C  C    B SER   C 1 204 ? 31.04500  4.59000   68.37700  0.390 17.30831  ?  356 SER   B C    1 
ATOM   3565 O  O    A SER   C 1 204 ? 31.72600  3.61600   68.73300  0.610 21.37914  ?  356 SER   B O    1 
ATOM   3566 O  O    B SER   C 1 204 ? 31.72700  3.61900   68.72400  0.390 21.31199  ?  356 SER   B O    1 
ATOM   3567 C  CB   A SER   C 1 204 ? 31.91200  6.13000   66.60500  0.610 18.86042  ?  356 SER   B CB   1 
ATOM   3568 C  CB   B SER   C 1 204 ? 31.89300  6.16700   66.62000  0.390 18.89307  ?  356 SER   B CB   1 
ATOM   3569 O  OG   A SER   C 1 204 ? 31.90000  6.44600   65.22400  0.610 19.34936  ?  356 SER   B OG   1 
ATOM   3570 O  OG   B SER   C 1 204 ? 33.17500  5.96000   67.18700  0.390 17.86642  ?  356 SER   B OG   1 
ATOM   3571 N  N    . ASN   C 1 205 ? 30.35600  5.32800   69.25200  1.000 19.00631  ?  357 ASN   B N    1 
ATOM   3572 C  CA   . ASN   C 1 205 ? 30.32900  4.97300   70.66900  1.000 20.47451  ?  357 ASN   B CA   1 
ATOM   3573 C  C    . ASN   C 1 205 ? 29.69400  3.60400   70.88000  1.000 20.56801  ?  357 ASN   B C    1 
ATOM   3574 O  O    . ASN   C 1 205 ? 30.14000  2.82700   71.73400  1.000 19.27884  ?  357 ASN   B O    1 
ATOM   3575 C  CB   . ASN   C 1 205 ? 29.56900  6.03500   71.46600  1.000 17.74587  ?  357 ASN   B CB   1 
ATOM   3576 C  CG   . ASN   C 1 205 ? 30.34500  7.32600   71.60100  1.000 33.91492  ?  357 ASN   B CG   1 
ATOM   3577 O  OD1  . ASN   C 1 205 ? 31.54700  7.36800   71.34700  1.000 34.44936  ?  357 ASN   B OD1  1 
ATOM   3578 N  ND2  . ASN   C 1 205 ? 29.65900  8.39200   72.00300  1.000 35.36496  ?  357 ASN   B ND2  1 
ATOM   3579 N  N    . THR   C 1 206 ? 28.64600  3.29500   70.11300  1.000 15.93960  ?  358 THR   B N    1 
ATOM   3580 C  CA   . THR   C 1 206 ? 28.02900  1.97400   70.18400  1.000 15.46545  ?  358 THR   B CA   1 
ATOM   3581 C  C    . THR   C 1 206 ? 29.01100  0.89300   69.75700  1.000 16.35576  ?  358 THR   B C    1 
ATOM   3582 O  O    . THR   C 1 206 ? 29.15600  -0.13400  70.43000  1.000 18.26164  ?  358 THR   B O    1 
ATOM   3583 C  CB   . THR   C 1 206 ? 26.77700  1.93100   69.30600  1.000 14.80968  ?  358 THR   B CB   1 
ATOM   3584 O  OG1  . THR   C 1 206 ? 25.82800  2.89200   69.77800  1.000 15.09642  ?  358 THR   B OG1  1 
ATOM   3585 C  CG2  . THR   C 1 206 ? 26.14300  0.55500   69.34600  1.000 13.34578  ?  358 THR   B CG2  1 
ATOM   3586 N  N    . LEU   C 1 207 ? 29.68900  1.10400   68.62700  1.000 13.33394  ?  359 LEU   B N    1 
ATOM   3587 C  CA   . LEU   C 1 207 ? 30.69800  0.14900   68.18700  1.000 15.92205  ?  359 LEU   B CA   1 
ATOM   3588 C  C    . LEU   C 1 207 ? 31.83400  0.07600   69.19200  1.000 20.21646  ?  359 LEU   B C    1 
ATOM   3589 O  O    . LEU   C 1 207 ? 32.30900  -1.01300  69.53400  1.000 13.95428  ?  359 LEU   B O    1 
ATOM   3590 C  CB   . LEU   C 1 207 ? 31.23500  0.53900   66.81000  1.000 11.29868  ?  359 LEU   B CB   1 
ATOM   3591 C  CG   . LEU   C 1 207 ? 32.42900  -0.28700  66.32200  1.000 17.95206  ?  359 LEU   B CG   1 
ATOM   3592 C  CD1  . LEU   C 1 207 ? 32.02900  -1.74600  66.13700  1.000 11.40059  ?  359 LEU   B CD1  1 
ATOM   3593 C  CD2  . LEU   C 1 207 ? 33.01600  0.29300   65.03500  1.000 21.01902  ?  359 LEU   B CD2  1 
ATOM   3594 N  N    . GLN   C 1 208 ? 32.28200  1.23900   69.67100  1.000 16.16281  ?  360 GLN   B N    1 
ATOM   3595 C  CA   . GLN   C 1 208 ? 33.36400  1.27600   70.64300  1.000 22.49505  ?  360 GLN   B CA   1 
ATOM   3596 C  C    . GLN   C 1 208 ? 33.00100  0.52300   71.90600  1.000 29.19279  ?  360 GLN   B C    1 
ATOM   3597 O  O    . GLN   C 1 208 ? 33.87600  -0.06200  72.53500  1.000 28.63707  ?  360 GLN   B O    1 
ATOM   3598 C  CB   . GLN   C 1 208 ? 33.72300  2.71100   71.00600  1.000 23.39064  ?  360 GLN   B CB   1 
ATOM   3599 C  CG   . GLN   C 1 208 ? 34.62300  3.40700   70.02900  1.000 24.05533  ?  360 GLN   B CG   1 
ATOM   3600 C  CD   . GLN   C 1 208 ? 34.69600  4.88200   70.31700  1.000 29.85141  ?  360 GLN   B CD   1 
ATOM   3601 O  OE1  . GLN   C 1 208 ? 34.55400  5.70500   69.41900  1.000 29.79575  ?  360 GLN   B OE1  1 
ATOM   3602 N  NE2  . GLN   C 1 208 ? 34.90400  5.22900   71.58300  1.000 39.43252  ?  360 GLN   B NE2  1 
ATOM   3603 N  N    . THR   C 1 209 ? 31.73000  0.56700   72.32100  1.000 21.56019  ?  361 THR   B N    1 
ATOM   3604 C  CA   . THR   C 1 209 ? 31.31400  -0.13400  73.53200  1.000 16.86967  ?  361 THR   B CA   1 
ATOM   3605 C  C    . THR   C 1 209 ? 31.06200  -1.61400  73.27400  1.000 24.16952  ?  361 THR   B C    1 
ATOM   3606 O  O    . THR   C 1 209 ? 31.29600  -2.44500  74.16200  1.000 20.18980  ?  361 THR   B O    1 
ATOM   3607 C  CB   . THR   C 1 209 ? 30.05800  0.51700   74.12100  1.000 17.07359  ?  361 THR   B CB   1 
ATOM   3608 O  OG1  . THR   C 1 209 ? 30.32700  1.89200   74.40800  1.000 18.19519  ?  361 THR   B OG1  1 
ATOM   3609 C  CG2  . THR   C 1 209 ? 29.62900  -0.18100  75.41100  1.000 21.96816  ?  361 THR   B CG2  1 
ATOM   3610 N  N    . TYR   C 1 210 ? 30.60000  -1.96700  72.07400  1.000 17.87317  ?  362 TYR   B N    1 
ATOM   3611 C  CA   . TYR   C 1 210 ? 30.40600  -3.37800  71.75800  1.000 18.56991  ?  362 TYR   B CA   1 
ATOM   3612 C  C    . TYR   C 1 210 ? 31.72800  -4.13900  71.80500  1.000 25.45370  ?  362 TYR   B C    1 
ATOM   3613 O  O    . TYR   C 1 210 ? 31.77600  -5.29100  72.25100  1.000 20.66171  ?  362 TYR   B O    1 
ATOM   3614 C  CB   . TYR   C 1 210 ? 29.75100  -3.52800  70.38200  1.000 14.38558  ?  362 TYR   B CB   1 
ATOM   3615 C  CG   . TYR   C 1 210 ? 29.47400  -4.96800  70.01400  1.000 17.52150  ?  362 TYR   B CG   1 
ATOM   3616 C  CD1  . TYR   C 1 210 ? 30.44300  -5.74600  69.38800  1.000 17.00687  ?  362 TYR   B CD1  1 
ATOM   3617 C  CD2  . TYR   C 1 210 ? 28.25000  -5.55700  70.31000  1.000 22.65686  ?  362 TYR   B CD2  1 
ATOM   3618 C  CE1  . TYR   C 1 210 ? 30.19900  -7.06600  69.06300  1.000 20.54311  ?  362 TYR   B CE1  1 
ATOM   3619 C  CE2  . TYR   C 1 210 ? 27.99600  -6.87800  69.98600  1.000 22.36269  ?  362 TYR   B CE2  1 
ATOM   3620 C  CZ   . TYR   C 1 210 ? 28.97300  -7.62500  69.36400  1.000 22.49854  ?  362 TYR   B CZ   1 
ATOM   3621 O  OH   . TYR   C 1 210 ? 28.72700  -8.93500  69.04300  1.000 26.94073  ?  362 TYR   B OH   1 
ATOM   3622 N  N    . ILE   C 1 211 ? 32.77100  -3.50800  71.29200  1.000 17.14031  ?  363 ILE   B N    1 
ATOM   3623 C  CA   . ILE   C 1 211 ? 34.09800  -4.17100  71.23000  1.000 20.20110  ?  363 ILE   B CA   1 
ATOM   3624 C  C    . ILE   C 1 211 ? 34.64400  -4.40100  72.64000  1.000 18.51228  ?  363 ILE   B C    1 
ATOM   3625 O  O    . ILE   C 1 211 ? 35.04300  -5.49900  72.89500  1.000 26.73529  ?  363 ILE   B O    1 
ATOM   3626 C  CB   . ILE   C 1 211 ? 35.05400  -3.34200  70.37000  1.000 19.48091  ?  363 ILE   B CB   1 
ATOM   3627 C  CG1  . ILE   C 1 211 ? 34.59000  -3.29900  68.91400  1.000 18.52706  ?  363 ILE   B CG1  1 
ATOM   3628 C  CG2  . ILE   C 1 211 ? 36.47000  -3.88000  70.51000  1.000 23.77883  ?  363 ILE   B CG2  1 
ATOM   3629 C  CD1  . ILE   C 1 211 ? 35.34900  -2.34900  68.07000  1.000 20.15240  ?  363 ILE   B CD1  1 
ATOM   3630 N  N    . ARG   C 1 212 ? 34.45600  -3.45500  73.53400  1.000 22.22174  ?  364 ARG   B N    1 
ATOM   3631 C  CA   . ARG   C 1 212 ? 34.95000  -3.57400  74.92900  1.000 26.12504  ?  364 ARG   B CA   1 
ATOM   3632 C  C    . ARG   C 1 212 ? 34.23800  -4.72500  75.66900  1.000 26.39020  ?  364 ARG   B C    1 
ATOM   3633 O  O    . ARG   C 1 212 ? 34.81600  -5.31800  76.52300  1.000 29.07107  ?  364 ARG   B O    1 
ATOM   3634 C  CB   . ARG   C 1 212 ? 34.82800  -2.20900  75.60000  1.000 29.11779  ?  364 ARG   B CB   1 
ATOM   3635 C  CG   . ARG   C 1 212 ? 35.81700  -1.17100  75.09900  1.000 29.66409  ?  364 ARG   B CG   1 
ATOM   3636 C  CD   . ARG   C 1 212 ? 35.85300  0.19300   75.76900  1.000 51.48767  ?  364 ARG   B CD   1 
ATOM   3637 N  NE   . ARG   C 1 212 ? 34.61100  0.88100   76.10700  1.000 62.07044  ?  364 ARG   B NE   1 
ATOM   3638 C  CZ   . ARG   C 1 212 ? 34.25000  2.06000   75.61600  1.000 61.75507  ?  364 ARG   B CZ   1 
ATOM   3639 N  NH1  . ARG   C 1 212 ? 35.02900  2.67400   74.74800  1.000 52.54869  ?  364 ARG   B NH1  1 
ATOM   3640 N  NH2  . ARG   C 1 212 ? 33.11400  2.62400   75.98400  1.000 50.77097  ?  364 ARG   B NH2  1 
ATOM   3641 N  N    . CYS   C 1 213 ? 32.98200  -4.98000  75.35600  1.000 29.90368  ?  365 CYS   B N    1 
ATOM   3642 C  CA   . CYS   C 1 213 ? 32.19400  -6.10000  75.92200  1.000 24.31415  ?  365 CYS   B CA   1 
ATOM   3643 C  C    . CYS   C 1 213 ? 32.74300  -7.46700  75.49300  1.000 38.75219  ?  365 CYS   B C    1 
ATOM   3644 O  O    . CYS   C 1 213 ? 32.56600  -8.40300  76.23500  1.000 37.29844  ?  365 CYS   B O    1 
ATOM   3645 C  CB   . CYS   C 1 213 ? 30.76200  -5.99400  75.45100  1.000 29.70036  ?  365 CYS   B CB   1 
ATOM   3646 S  SG   . CYS   C 1 213 ? 29.88100  -4.61500  76.20300  1.000 32.47482  ?  365 CYS   B SG   1 
ATOM   3647 N  N    . ARG   C 1 214 ? 33.37700  -7.56200  74.32700  1.000 34.82212  ?  366 ARG   B N    1 
ATOM   3648 C  CA   . ARG   C 1 214 ? 33.92800  -8.83500  73.79700  1.000 37.87673  ?  366 ARG   B CA   1 
ATOM   3649 C  C    . ARG   C 1 214 ? 35.43400  -8.96200  74.05000  1.000 35.95827  ?  366 ARG   B C    1 
ATOM   3650 O  O    . ARG   C 1 214 ? 35.87300  -10.07700 74.15600  1.000 35.05011  ?  366 ARG   B O    1 
ATOM   3651 C  CB   . ARG   C 1 214 ? 33.75100  -8.94600  72.28300  1.000 30.36364  ?  366 ARG   B CB   1 
ATOM   3652 C  CG   . ARG   C 1 214 ? 32.33400  -8.73400  71.79400  1.000 34.46158  ?  366 ARG   B CG   1 
ATOM   3653 C  CD   . ARG   C 1 214 ? 31.38000  -9.67700  72.45600  1.000 38.91274  ?  366 ARG   B CD   1 
ATOM   3654 N  NE   . ARG   C 1 214 ? 31.71500  -11.05400 72.21700  1.000 46.63526  ?  366 ARG   B NE   1 
ATOM   3655 C  CZ   . ARG   C 1 214 ? 30.86600  -12.06500 72.34600  1.000 65.96607  ?  366 ARG   B CZ   1 
ATOM   3656 N  NH1  . ARG   C 1 214 ? 29.61100  -11.83100 72.69400  1.000 56.94219  ?  366 ARG   B NH1  1 
ATOM   3657 N  NH2  . ARG   C 1 214 ? 31.27000  -13.29900 72.11000  1.000 62.71604  ?  366 ARG   B NH2  1 
ATOM   3658 N  N    . HIS   C 1 215 ? 36.17500  -7.86000  74.12500  1.000 30.84906  ?  367 HIS   B N    1 
ATOM   3659 C  CA   . HIS   C 1 215 ? 37.63200  -7.92200  74.22800  1.000 34.46058  ?  367 HIS   B CA   1 
ATOM   3660 C  C    . HIS   C 1 215 ? 38.17500  -6.96900  75.28500  1.000 34.50304  ?  367 HIS   B C    1 
ATOM   3661 O  O    . HIS   C 1 215 ? 37.80400  -5.78500  75.30400  1.000 30.47001  ?  367 HIS   B O    1 
ATOM   3662 C  CB   . HIS   C 1 215 ? 38.28400  -7.60300  72.87400  1.000 34.55167  ?  367 HIS   B CB   1 
ATOM   3663 C  CG   . HIS   C 1 215 ? 37.77700  -8.43800  71.74200  1.000 35.19195  ?  367 HIS   B CG   1 
ATOM   3664 N  ND1  . HIS   C 1 215 ? 38.21100  -9.72700  71.51400  1.000 34.00735  ?  367 HIS   B ND1  1 
ATOM   3665 C  CD2  . HIS   C 1 215 ? 36.89000  -8.16000  70.75700  1.000 29.70624  ?  367 HIS   B CD2  1 
ATOM   3666 C  CE1  . HIS   C 1 215 ? 37.60300  -10.21100 70.44500  1.000 37.99733  ?  367 HIS   B CE1  1 
ATOM   3667 N  NE2  . HIS   C 1 215 ? 36.79700  -9.28000  69.96700  1.000 32.77238  ?  367 HIS   B NE2  1 
ATOM   3668 N  N    . PRO   C 1 216 ? 39.08600  -7.42700  76.14000  1.000 27.72660  ?  368 PRO   B N    1 
ATOM   3669 C  CA   . PRO   C 1 216 ? 39.74500  -6.52200  77.08600  1.000 32.37285  ?  368 PRO   B CA   1 
ATOM   3670 C  C    . PRO   C 1 216 ? 40.77200  -5.66100  76.37400  1.000 24.08062  ?  368 PRO   B C    1 
ATOM   3671 O  O    . PRO   C 1 216 ? 41.16700  -5.96800  75.23900  1.000 27.74133  ?  368 PRO   B O    1 
ATOM   3672 C  CB   . PRO   C 1 216 ? 40.42300  -7.47900  78.08300  1.000 34.97820  ?  368 PRO   B CB   1 
ATOM   3673 C  CG   . PRO   C 1 216 ? 39.94700  -8.87000  77.72000  1.000 34.63833  ?  368 PRO   B CG   1 
ATOM   3674 C  CD   . PRO   C 1 216 ? 39.56700  -8.80900  76.27800  1.000 32.93190  ?  368 PRO   B CD   1 
ATOM   3675 N  N    . PRO   C 1 217 ? 41.23400  -4.57600  77.00100  1.000 24.24019  ?  369 PRO   B N    1 
ATOM   3676 C  CA   . PRO   C 1 217 ? 42.36000  -3.84100  76.43400  1.000 30.28595  ?  369 PRO   B CA   1 
ATOM   3677 C  C    . PRO   C 1 217 ? 43.64100  -4.63800  76.59600  1.000 33.50153  ?  369 PRO   B C    1 
ATOM   3678 O  O    . PRO   C 1 217 ? 43.75800  -5.46800  77.51400  1.000 27.47065  ?  369 PRO   B O    1 
ATOM   3679 C  CB   . PRO   C 1 217 ? 42.39200  -2.54600  77.26400  1.000 35.52450  ?  369 PRO   B CB   1 
ATOM   3680 C  CG   . PRO   C 1 217 ? 41.74500  -2.89800  78.55100  1.000 34.45584  ?  369 PRO   B CG   1 
ATOM   3681 C  CD   . PRO   C 1 217 ? 40.75800  -3.99500  78.27000  1.000 29.66256  ?  369 PRO   B CD   1 
ATOM   3682 N  N    . PRO   C 1 218 ? 44.63600  -4.42900  75.71800  1.000 35.15007  ?  370 PRO   B N    1 
ATOM   3683 C  CA   . PRO   C 1 218 ? 44.64600  -3.48200  74.60100  1.000 26.73417  ?  370 PRO   B CA   1 
ATOM   3684 C  C    . PRO   C 1 218 ? 44.03800  -4.03800  73.31500  1.000 27.49498  ?  370 PRO   B C    1 
ATOM   3685 O  O    . PRO   C 1 218 ? 43.92100  -3.29400  72.34000  1.000 23.51719  ?  370 PRO   B O    1 
ATOM   3686 C  CB   . PRO   C 1 218 ? 46.13400  -3.20600  74.40800  1.000 31.56139  ?  370 PRO   B CB   1 
ATOM   3687 C  CG   . PRO   C 1 218 ? 46.78100  -4.50200  74.77000  1.000 32.99871  ?  370 PRO   B CG   1 
ATOM   3688 C  CD   . PRO   C 1 218 ? 45.92500  -5.13600  75.84200  1.000 29.20285  ?  370 PRO   B CD   1 
ATOM   3689 N  N    . GLY   C 1 219 ? 43.66200  -5.32100  73.31600  1.000 17.94172  ?  371 GLY   B N    1 
ATOM   3690 C  CA   . GLY   C 1 219 ? 43.07500  -5.91100  72.12300  1.000 21.98685  ?  371 GLY   B CA   1 
ATOM   3691 C  C    . GLY   C 1 219 ? 41.84400  -5.17300  71.63700  1.000 27.08985  ?  371 GLY   B C    1 
ATOM   3692 O  O    . GLY   C 1 219 ? 41.59000  -5.10600  70.43000  1.000 22.19194  ?  371 GLY   B O    1 
ATOM   3693 N  N    . SER   C 1 220 ? 41.09100  -4.58900  72.55300  1.000 19.59390  ?  372 SER   B N    1 
ATOM   3694 C  CA   . SER   C 1 220 ? 39.86300  -3.85000  72.16300  1.000 29.51311  ?  372 SER   B CA   1 
ATOM   3695 C  C    . SER   C 1 220 ? 40.21700  -2.69500  71.22500  1.000 33.52030  ?  372 SER   B C    1 
ATOM   3696 O  O    . SER   C 1 220 ? 39.58900  -2.56200  70.20700  1.000 23.15735  ?  372 SER   B O    1 
ATOM   3697 C  CB   . SER   C 1 220 ? 39.18200  -3.32200  73.36700  1.000 29.57635  ?  372 SER   B CB   1 
ATOM   3698 O  OG   . SER   C 1 220 ? 40.11900  -2.68200  74.20200  1.000 29.62096  ?  372 SER   B OG   1 
ATOM   3699 N  N    . HIS   C 1 221 ? 41.21100  -1.90500  71.59700  1.000 26.56457  ?  373 HIS   B N    1 
ATOM   3700 C  CA   . HIS   C 1 221 ? 41.54700  -0.72700  70.80400  1.000 30.57303  ?  373 HIS   B CA   1 
ATOM   3701 C  C    . HIS   C 1 221 ? 42.31100  -1.09000  69.54500  1.000 30.00624  ?  373 HIS   B C    1 
ATOM   3702 O  O    . HIS   C 1 221 ? 42.21900  -0.38000  68.53800  1.000 25.32735  ?  373 HIS   B O    1 
ATOM   3703 C  CB   . HIS   C 1 221 ? 42.34600  0.21700   71.68700  1.000 34.01679  ?  373 HIS   B CB   1 
ATOM   3704 C  CG   . HIS   C 1 221 ? 41.84500  0.22600   73.09300  1.000 60.47574  ?  373 HIS   B CG   1 
ATOM   3705 N  ND1  . HIS   C 1 221 ? 42.67500  0.20900   74.19200  1.000 57.51323  ?  373 HIS   B ND1  1 
ATOM   3706 C  CD2  . HIS   C 1 221 ? 40.57800  0.23200   73.57600  1.000 59.38915  ?  373 HIS   B CD2  1 
ATOM   3707 C  CE1  . HIS   C 1 221 ? 41.93600  0.19200   75.28900  1.000 51.73630  ?  373 HIS   B CE1  1 
ATOM   3708 N  NE2  . HIS   C 1 221 ? 40.66100  0.21300   74.94500  1.000 53.05259  ?  373 HIS   B NE2  1 
ATOM   3709 N  N    . GLN   C 1 222 ? 43.06900  -2.18500  69.58600  1.000 23.64277  ?  374 GLN   B N    1 
ATOM   3710 C  CA   . GLN   C 1 222 ? 43.71600  -2.65700  68.37200  1.000 21.67066  ?  374 GLN   B CA   1 
ATOM   3711 C  C    . GLN   C 1 222 ? 42.67900  -3.05600  67.32800  1.000 19.77843  ?  374 GLN   B C    1 
ATOM   3712 O  O    . GLN   C 1 222 ? 42.82800  -2.73000  66.14600  1.000 22.38653  ?  374 GLN   B O    1 
ATOM   3713 C  CB   . GLN   C 1 222 ? 44.66300  -3.81300  68.70200  1.000 24.79430  ?  374 GLN   B CB   1 
ATOM   3714 C  CG   . GLN   C 1 222 ? 45.89700  -3.35100  69.48300  1.000 22.83113  ?  374 GLN   B CG   1 
ATOM   3715 C  CD   . GLN   C 1 222 ? 46.67200  -4.49100  70.11900  1.000 25.70480  ?  374 GLN   B CD   1 
ATOM   3716 O  OE1  . GLN   C 1 222 ? 47.69800  -4.27300  70.77100  1.000 30.15860  ?  374 GLN   B OE1  1 
ATOM   3717 N  NE2  . GLN   C 1 222 ? 46.18800  -5.71100  69.93600  1.000 21.87865  ?  374 GLN   B NE2  1 
ATOM   3718 N  N    . LEU   C 1 223 ? 41.59500  -3.71800  67.74900  1.000 20.63708  ?  375 LEU   B N    1 
ATOM   3719 C  CA   . LEU   C 1 223 ? 40.55200  -4.09300  66.79300  1.000 22.21172  ?  375 LEU   B CA   1 
ATOM   3720 C  C    . LEU   C 1 223 ? 39.81100  -2.86700  66.26700  1.000 24.31052  ?  375 LEU   B C    1 
ATOM   3721 O  O    . LEU   C 1 223 ? 39.54000  -2.77000  65.06400  1.000 23.84285  ?  375 LEU   B O    1 
ATOM   3722 C  CB   . LEU   C 1 223 ? 39.56400  -5.07700  67.42400  1.000 22.83412  ?  375 LEU   B CB   1 
ATOM   3723 C  CG   . LEU   C 1 223 ? 38.31900  -5.36800  66.57400  1.000 23.65014  ?  375 LEU   B CG   1 
ATOM   3724 C  CD1  . LEU   C 1 223 ? 38.69600  -5.96500  65.22000  1.000 20.31028  ?  375 LEU   B CD1  1 
ATOM   3725 C  CD2  . LEU   C 1 223 ? 37.32800  -6.27100  67.30700  1.000 29.48794  ?  375 LEU   B CD2  1 
ATOM   3726 N  N    . TYR   C 1 224 ? 39.46700  -1.92600  67.15100  1.000 23.68149  ?  376 TYR   B N    1 
ATOM   3727 C  CA   . TYR   C 1 224 ? 38.79100  -0.71200  66.70300  1.000 19.71622  ?  376 TYR   B CA   1 
ATOM   3728 C  C    . TYR   C 1 224 ? 39.66600  0.07800   65.74000  1.000 28.24248  ?  376 TYR   B C    1 
ATOM   3729 O  O    . TYR   C 1 224 ? 39.17900  0.59300   64.72600  1.000 26.00222  ?  376 TYR   B O    1 
ATOM   3730 C  CB   . TYR   C 1 224 ? 38.40000  0.15400   67.90200  1.000 20.54252  ?  376 TYR   B CB   1 
ATOM   3731 C  CG   . TYR   C 1 224 ? 37.66000  1.41900   67.51300  1.000 27.52958  ?  376 TYR   B CG   1 
ATOM   3732 C  CD1  . TYR   C 1 224 ? 36.43300  1.35700   66.86000  1.000 28.41537  ?  376 TYR   B CD1  1 
ATOM   3733 C  CD2  . TYR   C 1 224 ? 38.19000  2.67300   67.79100  1.000 22.07980  ?  376 TYR   B CD2  1 
ATOM   3734 C  CE1  . TYR   C 1 224 ? 35.75200  2.51000   66.50000  1.000 24.59253  ?  376 TYR   B CE1  1 
ATOM   3735 C  CE2  . TYR   C 1 224 ? 37.51500  3.83200   67.43400  1.000 24.33462  ?  376 TYR   B CE2  1 
ATOM   3736 C  CZ   . TYR   C 1 224 ? 36.30000  3.74400   66.79100  1.000 23.67810  ?  376 TYR   B CZ   1 
ATOM   3737 O  OH   . TYR   C 1 224 ? 35.62800  4.89000   66.43500  1.000 27.95849  ?  376 TYR   B OH   1 
ATOM   3738 N  N    . ALA   C 1 225 ? 40.96500  0.18100   66.04000  1.000 25.88712  ?  377 ALA   B N    1 
ATOM   3739 C  CA   . ALA   C 1 225 ? 41.88300  0.87200   65.14000  1.000 26.03928  ?  377 ALA   B CA   1 
ATOM   3740 C  C    . ALA   C 1 225 ? 41.93100  0.19700   63.77500  1.000 25.17757  ?  377 ALA   B C    1 
ATOM   3741 O  O    . ALA   C 1 225 ? 41.99000  0.87300   62.74200  1.000 26.41850  ?  377 ALA   B O    1 
ATOM   3742 C  CB   . ALA   C 1 225 ? 43.28100  0.93400   65.75700  1.000 27.51588  ?  377 ALA   B CB   1 
ATOM   3743 N  N    . LYS   C 1 226 ? 41.90100  -1.13800  63.75000  1.000 19.69864  ?  378 LYS   B N    1 
ATOM   3744 C  CA   . LYS   C 1 226 ? 41.89300  -1.84400  62.47200  1.000 25.84951  ?  378 LYS   B CA   1 
ATOM   3745 C  C    . LYS   C 1 226 ? 40.60900  -1.57800  61.69500  1.000 21.44558  ?  378 LYS   B C    1 
ATOM   3746 O  O    . LYS   C 1 226 ? 40.63500  -1.52500  60.45900  1.000 20.22267  ?  378 LYS   B O    1 
ATOM   3747 C  CB   . LYS   C 1 226 ? 42.08000  -3.34500  62.69400  1.000 23.98226  ?  378 LYS   B CB   1 
ATOM   3748 C  CG   . LYS   C 1 226 ? 43.47700  -3.73700  63.16800  1.000 28.34165  ?  378 LYS   B CG   1 
ATOM   3749 C  CD   . LYS   C 1 226 ? 43.61600  -5.24900  63.27500  1.000 31.90056  ?  378 LYS   B CD   1 
ATOM   3750 C  CE   . LYS   C 1 226 ? 44.82100  -5.64700  64.11300  1.000 40.91917  ?  378 LYS   B CE   1 
ATOM   3751 N  NZ   . LYS   C 1 226 ? 46.09700  -5.11300  63.56300  1.000 36.33425  ?  378 LYS   B NZ   1 
ATOM   3752 N  N    . MET   C 1 227 ? 39.48400  -1.40300  62.39400  1.000 21.42090  ?  379 MET   B N    1 
ATOM   3753 C  CA   . MET   C 1 227 ? 38.22900  -1.09700  61.71300  1.000 16.71283  ?  379 MET   B CA   1 
ATOM   3754 C  C    . MET   C 1 227 ? 38.24200  0.31400   61.13500  1.000 21.59122  ?  379 MET   B C    1 
ATOM   3755 O  O    . MET   C 1 227 ? 37.72300  0.54600   60.03700  1.000 18.79469  ?  379 MET   B O    1 
ATOM   3756 C  CB   . MET   C 1 227 ? 37.05200  -1.27800  62.67500  1.000 18.84085  ?  379 MET   B CB   1 
ATOM   3757 C  CG   . MET   C 1 227 ? 36.82700  -2.72200  63.12300  1.000 19.50945  ?  379 MET   B CG   1 
ATOM   3758 S  SD   . MET   C 1 227 ? 35.37000  -2.94400  64.17200  1.000 20.70604  ?  379 MET   B SD   1 
ATOM   3759 C  CE   . MET   C 1 227 ? 34.05100  -2.81200  62.96800  1.000 28.09223  ?  379 MET   B CE   1 
ATOM   3760 N  N    . ILE   C 1 228 ? 38.82900  1.27100   61.85700  1.000 19.22236  ?  380 ILE   B N    1 
ATOM   3761 C  CA   . ILE   C 1 228 ? 38.91800  2.63200   61.33500  1.000 25.55719  ?  380 ILE   B CA   1 
ATOM   3762 C  C    . ILE   C 1 228 ? 39.87400  2.68400   60.15100  1.000 23.15129  ?  380 ILE   B C    1 
ATOM   3763 O  O    . ILE   C 1 228 ? 39.64700  3.41800   59.18200  1.000 24.15425  ?  380 ILE   B O    1 
ATOM   3764 C  CB   . ILE   C 1 228 ? 39.33500  3.60700   62.45200  1.000 27.26417  ?  380 ILE   B CB   1 
ATOM   3765 C  CG1  . ILE   C 1 228 ? 38.29400  3.61700   63.57200  1.000 28.71889  ?  380 ILE   B CG1  1 
ATOM   3766 C  CG2  . ILE   C 1 228 ? 39.51600  5.01200   61.90100  1.000 44.47346  ?  380 ILE   B CG2  1 
ATOM   3767 C  CD1  . ILE   C 1 228 ? 36.85500  3.55700   63.08900  1.000 35.52597  ?  380 ILE   B CD1  1 
ATOM   3768 N  N    . GLN   C 1 229 ? 40.95500  1.90200   60.20400  1.000 21.91348  ?  381 GLN   B N    1 
ATOM   3769 C  CA   . GLN   C 1 229 ? 41.86600  1.82400   59.06800  1.000 27.60711  ?  381 GLN   B CA   1 
ATOM   3770 C  C    . GLN   C 1 229 ? 41.15300  1.29500   57.83000  1.000 25.58626  ?  381 GLN   B C    1 
ATOM   3771 O  O    . GLN   C 1 229 ? 41.40400  1.76500   56.71400  1.000 23.04642  ?  381 GLN   B O    1 
ATOM   3772 C  CB   . GLN   C 1 229 ? 43.06600  0.94200   59.41100  1.000 20.50572  ?  381 GLN   B CB   1 
ATOM   3773 C  CG   . GLN   C 1 229 ? 44.18500  1.00200   58.38000  1.000 30.00033  ?  381 GLN   B CG   1 
ATOM   3774 C  CD   . GLN   C 1 229 ? 44.56400  2.42500   58.01600  1.000 32.86400  ?  381 GLN   B CD   1 
ATOM   3775 O  OE1  . GLN   C 1 229 ? 44.92200  3.22500   58.88100  1.000 40.03915  ?  381 GLN   B OE1  1 
ATOM   3776 N  NE2  . GLN   C 1 229 ? 44.48100  2.74800   56.73100  1.000 39.60224  ?  381 GLN   B NE2  1 
ATOM   3777 N  N    . LYS   C 1 230 ? 40.25700  0.31900   58.00800  1.000 20.32295  ?  382 LYS   B N    1 
ATOM   3778 C  CA   . LYS   C 1 230 ? 39.49400  -0.19700  56.87500  1.000 26.68432  ?  382 LYS   B CA   1 
ATOM   3779 C  C    . LYS   C 1 230 ? 38.60300  0.87800   56.26500  1.000 20.14367  ?  382 LYS   B C    1 
ATOM   3780 O  O    . LYS   C 1 230 ? 38.35800  0.86500   55.05300  1.000 17.94560  ?  382 LYS   B O    1 
ATOM   3781 C  CB   . LYS   C 1 230 ? 38.66200  -1.40600  57.30800  1.000 20.09388  ?  382 LYS   B CB   1 
ATOM   3782 C  CG   . LYS   C 1 230 ? 39.47700  -2.67600  57.54100  1.000 21.06671  ?  382 LYS   B CG   1 
ATOM   3783 C  CD   . LYS   C 1 230 ? 40.00800  -3.24400  56.22700  1.000 33.57961  ?  382 LYS   B CD   1 
ATOM   3784 C  CE   . LYS   C 1 230 ? 41.01600  -4.36300  56.46100  1.000 35.02508  ?  382 LYS   B CE   1 
ATOM   3785 N  NZ   . LYS   C 1 230 ? 42.41800  -3.87700  56.35400  1.000 28.07787  ?  382 LYS   B NZ   1 
ATOM   3786 N  N    . LEU   C 1 231 ? 38.11400  1.81700   57.08200  1.000 17.99803  ?  383 LEU   B N    1 
ATOM   3787 C  CA   . LEU   C 1 231 ? 37.34700  2.93700   56.54000  1.000 22.25281  ?  383 LEU   B CA   1 
ATOM   3788 C  C    . LEU   C 1 231 ? 38.23200  3.86800   55.72000  1.000 24.47844  ?  383 LEU   B C    1 
ATOM   3789 O  O    . LEU   C 1 231 ? 37.79600  4.41000   54.69700  1.000 23.15877  ?  383 LEU   B O    1 
ATOM   3790 C  CB   . LEU   C 1 231 ? 36.67000  3.70800   57.67200  1.000 20.88327  ?  383 LEU   B CB   1 
ATOM   3791 C  CG   . LEU   C 1 231 ? 35.49100  3.00900   58.34100  1.000 20.32273  ?  383 LEU   B CG   1 
ATOM   3792 C  CD1  . LEU   C 1 231 ? 34.81800  3.94100   59.33800  1.000 24.01616  ?  383 LEU   B CD1  1 
ATOM   3793 C  CD2  . LEU   C 1 231 ? 34.50300  2.53200   57.28500  1.000 17.99970  ?  383 LEU   B CD2  1 
ATOM   3794 N  N    . ALA   C 1 232 ? 39.47200  4.08100   56.16300  1.000 20.64656  ?  384 ALA   B N    1 
ATOM   3795 C  CA   . ALA   C 1 232 ? 40.40800  4.88300   55.38100  1.000 22.67924  ?  384 ALA   B CA   1 
ATOM   3796 C  C    . ALA   C 1 232 ? 40.79400  4.17400   54.09000  1.000 22.46483  ?  384 ALA   B C    1 
ATOM   3797 O  O    . ALA   C 1 232 ? 40.92600  4.81200   53.03800  1.000 25.15215  ?  384 ALA   B O    1 
ATOM   3798 C  CB   . ALA   C 1 232 ? 41.64900  5.20000   56.21500  1.000 23.15141  ?  384 ALA   B CB   1 
ATOM   3799 N  N    . ASP   C 1 233 ? 40.97900  2.85100   54.15000  1.000 22.56046  ?  385 ASP   B N    1 
ATOM   3800 C  CA   . ASP   C 1 233 ? 41.25000  2.08200   52.93900  1.000 23.14497  ?  385 ASP   B CA   1 
ATOM   3801 C  C    . ASP   C 1 233 ? 40.12900  2.24600   51.92000  1.000 27.36251  ?  385 ASP   B C    1 
ATOM   3802 O  O    . ASP   C 1 233 ? 40.38300  2.31600   50.71100  1.000 22.26017  ?  385 ASP   B O    1 
ATOM   3803 C  CB   . ASP   C 1 233 ? 41.43500  0.60300   53.28300  1.000 24.48986  ?  385 ASP   B CB   1 
ATOM   3804 C  CG   . ASP   C 1 233 ? 42.70700  0.33500   54.07100  1.000 31.70055  ?  385 ASP   B CG   1 
ATOM   3805 O  OD1  . ASP   C 1 233 ? 42.91800  -0.82900  54.47100  1.000 32.55562  ?  385 ASP   B OD1  1 
ATOM   3806 O  OD2  . ASP   C 1 233 ? 43.48800  1.28100   54.29700  1.000 28.77250  ?  385 ASP   B OD2  1 
ATOM   3807 N  N    . LEU   C 1 234 ? 38.88100  2.31100   52.39100  1.000 20.62056  ?  386 LEU   B N    1 
ATOM   3808 C  CA   . LEU   C 1 234 ? 37.74800  2.41400   51.47800  1.000 18.91867  ?  386 LEU   B CA   1 
ATOM   3809 C  C    . LEU   C 1 234 ? 37.74700  3.73700   50.72300  1.000 14.46881  ?  386 LEU   B C    1 
ATOM   3810 O  O    . LEU   C 1 234 ? 37.31600  3.78600   49.56600  1.000 22.46399  ?  386 LEU   B O    1 
ATOM   3811 C  CB   . LEU   C 1 234 ? 36.44000  2.23400   52.25000  1.000 13.71698  ?  386 LEU   B CB   1 
ATOM   3812 C  CG   . LEU   C 1 234 ? 36.10200  0.78000   52.55900  1.000 16.82764  ?  386 LEU   B CG   1 
ATOM   3813 C  CD1  . LEU   C 1 234 ? 35.06200  0.69500   53.66400  1.000 18.85643  ?  386 LEU   B CD1  1 
ATOM   3814 C  CD2  . LEU   C 1 234 ? 35.61500  0.07100   51.30600  1.000 20.58921  ?  386 LEU   B CD2  1 
ATOM   3815 N  N    . ARG   C 1 235 ? 38.21100  4.81500   51.35800  1.000 15.51143  ?  387 ARG   B N    1 
ATOM   3816 C  CA   . ARG   C 1 235 ? 38.33500  6.08600   50.65300  1.000 17.25449  ?  387 ARG   B CA   1 
ATOM   3817 C  C    . ARG   C 1 235 ? 39.28100  5.96100   49.46800  1.000 23.06207  ?  387 ARG   B C    1 
ATOM   3818 O  O    . ARG   C 1 235 ? 38.99900  6.48200   48.38100  1.000 24.70088  ?  387 ARG   B O    1 
ATOM   3819 C  CB   . ARG   C 1 235 ? 38.82300  7.17500   51.60700  1.000 21.24575  ?  387 ARG   B CB   1 
ATOM   3820 C  CG   . ARG   C 1 235 ? 37.95900  7.36300   52.82700  1.000 25.60359  ?  387 ARG   B CG   1 
ATOM   3821 C  CD   . ARG   C 1 235 ? 36.62200  7.96300   52.44500  1.000 25.17790  ?  387 ARG   B CD   1 
ATOM   3822 N  NE   . ARG   C 1 235 ? 35.77300  8.17600   53.61100  1.000 25.96358  ?  387 ARG   B NE   1 
ATOM   3823 C  CZ   . ARG   C 1 235 ? 35.45000  9.37300   54.09000  1.000 28.61681  ?  387 ARG   B CZ   1 
ATOM   3824 N  NH1  . ARG   C 1 235 ? 35.90900  10.47200  53.50400  1.000 25.04019  ?  387 ARG   B NH1  1 
ATOM   3825 N  NH2  . ARG   C 1 235 ? 34.66900  9.46900   55.15700  1.000 27.96532  ?  387 ARG   B NH2  1 
ATOM   3826 N  N    . SER   C 1 236 ? 40.40600  5.26400   49.65900  1.000 19.92729  ?  388 SER   B N    1 
ATOM   3827 C  CA   . SER   C 1 236 ? 41.36100  5.07400   48.57200  1.000 18.98374  ?  388 SER   B CA   1 
ATOM   3828 C  C    . SER   C 1 236 ? 40.78000  4.18600   47.47900  1.000 22.00403  ?  388 SER   B C    1 
ATOM   3829 O  O    . SER   C 1 236 ? 40.96700  4.45600   46.28700  1.000 20.34860  ?  388 SER   B O    1 
ATOM   3830 C  CB   . SER   C 1 236 ? 42.66200  4.48000   49.12100  1.000 17.42243  ?  388 SER   B CB   1 
ATOM   3831 O  OG   . SER   C 1 236 ? 43.50000  4.02300   48.07600  1.000 33.57061  ?  388 SER   B OG   1 
ATOM   3832 N  N    . LEU   C 1 237 ? 40.07000  3.12400   47.86700  1.000 18.26545  ?  389 LEU   B N    1 
ATOM   3833 C  CA   . LEU   C 1 237 ? 39.39000  2.29100   46.88100  1.000 16.72680  ?  389 LEU   B CA   1 
ATOM   3834 C  C    . LEU   C 1 237 ? 38.30800  3.08200   46.15900  1.000 17.31373  ?  389 LEU   B C    1 
ATOM   3835 O  O    . LEU   C 1 237 ? 38.09200  2.89800   44.95500  1.000 18.65139  ?  389 LEU   B O    1 
ATOM   3836 C  CB   . LEU   C 1 237 ? 38.79300  1.05400   47.55700  1.000 18.01953  ?  389 LEU   B CB   1 
ATOM   3837 C  CG   . LEU   C 1 237 ? 39.79100  0.00800   48.06400  1.000 20.81985  ?  389 LEU   B CG   1 
ATOM   3838 C  CD1  . LEU   C 1 237 ? 39.12100  -0.97000  49.02100  1.000 24.67207  ?  389 LEU   B CD1  1 
ATOM   3839 C  CD2  . LEU   C 1 237 ? 40.45000  -0.72900  46.90200  1.000 18.25256  ?  389 LEU   B CD2  1 
ATOM   3840 N  N    . ASN   C 1 238 ? 37.61900  3.96600   46.88600  1.000 16.72123  ?  390 ASN   B N    1 
ATOM   3841 C  CA   . ASN   C 1 238 ? 36.63500  4.86100   46.27800  1.000 15.13976  ?  390 ASN   B CA   1 
ATOM   3842 C  C    . ASN   C 1 238 ? 37.27900  5.72500   45.19800  1.000 26.13687  ?  390 ASN   B C    1 
ATOM   3843 O  O    . ASN   C 1 238 ? 36.77500  5.81400   44.07100  1.000 20.51617  ?  390 ASN   B O    1 
ATOM   3844 C  CB   . ASN   C 1 238 ? 36.00700  5.73400   47.37100  1.000 19.59581  ?  390 ASN   B CB   1 
ATOM   3845 C  CG   . ASN   C 1 238 ? 34.71100  6.40700   46.94000  1.000 28.18546  ?  390 ASN   B CG   1 
ATOM   3846 O  OD1  . ASN   C 1 238 ? 33.86200  6.71900   47.78000  1.000 25.01060  ?  390 ASN   B OD1  1 
ATOM   3847 N  ND2  . ASN   C 1 238 ? 34.55900  6.65300   45.64600  1.000 18.08927  ?  390 ASN   B ND2  1 
ATOM   3848 N  N    . GLU   C 1 239 ? 38.39900  6.37200   45.52800  1.000 21.52691  ?  391 GLU   B N    1 
ATOM   3849 C  CA   . GLU   C 1 239 ? 39.04600  7.26400   44.57100  1.000 24.64928  ?  391 GLU   B CA   1 
ATOM   3850 C  C    . GLU   C 1 239 ? 39.51800  6.50600   43.33400  1.000 17.12295  ?  391 GLU   B C    1 
ATOM   3851 O  O    . GLU   C 1 239 ? 39.32200  6.96900   42.20400  1.000 21.12039  ?  391 GLU   B O    1 
ATOM   3852 C  CB   . GLU   C 1 239 ? 40.21000  7.99800   45.24100  1.000 27.25845  ?  391 GLU   B CB   1 
ATOM   3853 C  CG   . GLU   C 1 239 ? 39.81900  8.83700   46.45700  1.000 34.91531  ?  391 GLU   B CG   1 
ATOM   3854 C  CD   . GLU   C 1 239 ? 38.57000  9.68100   46.24200  1.000 65.29451  ?  391 GLU   B CD   1 
ATOM   3855 O  OE1  . GLU   C 1 239 ? 38.71300  10.88900  45.96000  1.000 83.27178  ?  391 GLU   B OE1  1 
ATOM   3856 O  OE2  . GLU   C 1 239 ? 37.45000  9.15100   46.39400  1.000 57.52381  ?  391 GLU   B OE2  1 
ATOM   3857 N  N    . GLU   C 1 240 ? 40.12800  5.33300   43.52100  1.000 19.57960  ?  392 GLU   B N    1 
ATOM   3858 C  CA   . GLU   C 1 240 ? 40.58000  4.56700   42.36400  1.000 25.84551  ?  392 GLU   B CA   1 
ATOM   3859 C  C    . GLU   C 1 240 ? 39.40200  4.07400   41.53100  1.000 24.32692  ?  392 GLU   B C    1 
ATOM   3860 O  O    . GLU   C 1 240 ? 39.46600  4.07800   40.29400  1.000 21.47351  ?  392 GLU   B O    1 
ATOM   3861 C  CB   . GLU   C 1 240 ? 41.45500  3.38900   42.80100  1.000 21.62798  ?  392 GLU   B CB   1 
ATOM   3862 C  CG   . GLU   C 1 240 ? 41.98800  2.54800   41.63800  1.000 21.08998  ?  392 GLU   B CG   1 
ATOM   3863 C  CD   . GLU   C 1 240 ? 42.94000  3.31500   40.71900  1.000 32.16955  ?  392 GLU   B CD   1 
ATOM   3864 O  OE1  . GLU   C 1 240 ? 42.96200  3.02900   39.50100  1.000 32.48503  ?  392 GLU   B OE1  1 
ATOM   3865 O  OE2  . GLU   C 1 240 ? 43.67100  4.19800   41.21200  1.000 31.85345  ?  392 GLU   B OE2  1 
ATOM   3866 N  N    . HIS   C 1 241 ? 38.31600  3.64300   42.18000  1.000 17.81772  ?  393 HIS   B N    1 
ATOM   3867 C  CA   . HIS   C 1 241 ? 37.14900  3.22700   41.40900  1.000 16.99565  ?  393 HIS   B CA   1 
ATOM   3868 C  C    . HIS   C 1 241 ? 36.55700  4.39600   40.63800  1.000 17.50781  ?  393 HIS   B C    1 
ATOM   3869 O  O    . HIS   C 1 241 ? 36.12700  4.23400   39.48900  1.000 20.59863  ?  393 HIS   B O    1 
ATOM   3870 C  CB   . HIS   C 1 241 ? 36.07100  2.61100   42.30100  1.000 18.05567  ?  393 HIS   B CB   1 
ATOM   3871 C  CG   . HIS   C 1 241 ? 34.82900  2.25100   41.54400  1.000 18.67962  ?  393 HIS   B CG   1 
ATOM   3872 N  ND1  . HIS   C 1 241 ? 33.76400  3.11500   41.40400  1.000 20.48961  ?  393 HIS   B ND1  1 
ATOM   3873 C  CD2  . HIS   C 1 241 ? 34.50600  1.13900   40.84100  1.000 16.51599  ?  393 HIS   B CD2  1 
ATOM   3874 C  CE1  . HIS   C 1 241 ? 32.82800  2.54100   40.66800  1.000 23.75539  ?  393 HIS   B CE1  1 
ATOM   3875 N  NE2  . HIS   C 1 241 ? 33.25300  1.34200   40.31400  1.000 18.70865  ?  393 HIS   B NE2  1 
ATOM   3876 N  N    A SER   C 1 242 ? 36.52200  5.57900   41.25700  0.510 20.35569  ?  394 SER   B N    1 
ATOM   3877 N  N    B SER   C 1 242 ? 36.52400  5.58100   41.25100  0.490 20.36181  ?  394 SER   B N    1 
ATOM   3878 C  CA   A SER   C 1 242 ? 36.00400  6.76700   40.58400  0.510 24.48506  ?  394 SER   B CA   1 
ATOM   3879 C  CA   B SER   C 1 242 ? 35.99200  6.75700   40.56700  0.490 24.45935  ?  394 SER   B CA   1 
ATOM   3880 C  C    A SER   C 1 242 ? 36.75900  7.03900   39.28900  0.510 26.97993  ?  394 SER   B C    1 
ATOM   3881 C  C    B SER   C 1 242 ? 36.75900  7.03700   39.28000  0.490 26.97315  ?  394 SER   B C    1 
ATOM   3882 O  O    A SER   C 1 242 ? 36.15200  7.29000   38.24100  0.510 23.59820  ?  394 SER   B O    1 
ATOM   3883 O  O    B SER   C 1 242 ? 36.15900  7.29200   38.22900  0.490 23.59544  ?  394 SER   B O    1 
ATOM   3884 C  CB   A SER   C 1 242 ? 36.09300  7.97300   41.52100  0.510 21.94387  ?  394 SER   B CB   1 
ATOM   3885 C  CB   B SER   C 1 242 ? 36.03900  7.97200   41.49500  0.490 22.00391  ?  394 SER   B CB   1 
ATOM   3886 O  OG   A SER   C 1 242 ? 35.38500  9.08400   40.99800  0.510 23.63920  ?  394 SER   B OG   1 
ATOM   3887 O  OG   B SER   C 1 242 ? 35.17900  7.79400   42.60500  0.490 23.90442  ?  394 SER   B OG   1 
ATOM   3888 N  N    . LYS   C 1 243 ? 38.09200  6.98500   39.34400  1.000 22.71245  ?  395 LYS   B N    1 
ATOM   3889 C  CA   . LYS   C 1 243 ? 38.90100  7.23100   38.15300  1.000 20.73920  ?  395 LYS   B CA   1 
ATOM   3890 C  C    . LYS   C 1 243 ? 38.59400  6.21700   37.05800  1.000 19.83943  ?  395 LYS   B C    1 
ATOM   3891 O  O    . LYS   C 1 243 ? 38.38300  6.58400   35.89700  1.000 23.84239  ?  395 LYS   B O    1 
ATOM   3892 C  CB   . LYS   C 1 243 ? 40.38800  7.19600   38.51200  1.000 29.74027  ?  395 LYS   B CB   1 
ATOM   3893 C  CG   . LYS   C 1 243 ? 40.89100  8.44100   39.22600  1.000 36.83277  ?  395 LYS   B CG   1 
ATOM   3894 C  CD   . LYS   C 1 243 ? 42.38900  8.35000   39.49500  1.000 47.04343  ?  395 LYS   B CD   1 
ATOM   3895 C  CE   . LYS   C 1 243 ? 42.85900  9.46200   40.41900  1.000 41.11170  ?  395 LYS   B CE   1 
ATOM   3896 N  NZ   . LYS   C 1 243 ? 43.72400  8.94900   41.51800  1.000 55.79905  ?  395 LYS   B NZ   1 
ATOM   3897 N  N    . GLN   C 1 244 ? 38.55400  4.93100   37.41200  1.000 14.72208  ?  396 GLN   B N    1 
ATOM   3898 C  CA   . GLN   C 1 244 ? 38.29400  3.90200   36.41100  1.000 19.41233  ?  396 GLN   B CA   1 
ATOM   3899 C  C    . GLN   C 1 244 ? 36.86200  3.97500   35.89400  1.000 21.35230  ?  396 GLN   B C    1 
ATOM   3900 O  O    . GLN   C 1 244 ? 36.62400  3.81000   34.69100  1.000 23.82130  ?  396 GLN   B O    1 
ATOM   3901 C  CB   . GLN   C 1 244 ? 38.60000  2.52000   36.99000  1.000 23.15523  ?  396 GLN   B CB   1 
ATOM   3902 C  CG   . GLN   C 1 244 ? 40.06000  2.35300   37.39100  1.000 21.23550  ?  396 GLN   B CG   1 
ATOM   3903 C  CD   . GLN   C 1 244 ? 40.49800  0.90600   37.45500  1.000 23.31986  ?  396 GLN   B CD   1 
ATOM   3904 O  OE1  . GLN   C 1 244 ? 39.78000  0.00400   37.01600  1.000 25.87915  ?  396 GLN   B OE1  1 
ATOM   3905 N  NE2  . GLN   C 1 244 ? 41.68900  0.67500   37.99900  1.000 25.72392  ?  396 GLN   B NE2  1 
ATOM   3906 N  N    . TYR   C 1 245 ? 35.89300  4.23200   36.77900  1.000 21.25319  ?  397 TYR   B N    1 
ATOM   3907 C  CA   . TYR   C 1 245 ? 34.51100  4.37500   36.32700  1.000 20.67537  ?  397 TYR   B CA   1 
ATOM   3908 C  C    . TYR   C 1 245 ? 34.36700  5.55300   35.37100  1.000 23.27418  ?  397 TYR   B C    1 
ATOM   3909 O  O    . TYR   C 1 245 ? 33.68800  5.44900   34.34200  1.000 20.53970  ?  397 TYR   B O    1 
ATOM   3910 C  CB   . TYR   C 1 245 ? 33.57000  4.54700   37.52100  1.000 20.55324  ?  397 TYR   B CB   1 
ATOM   3911 C  CG   . TYR   C 1 245 ? 32.13600  4.81100   37.10500  1.000 19.86629  ?  397 TYR   B CG   1 
ATOM   3912 C  CD1  . TYR   C 1 245 ? 31.27300  3.76100   36.82300  1.000 19.87552  ?  397 TYR   B CD1  1 
ATOM   3913 C  CD2  . TYR   C 1 245 ? 31.65300  6.11000   36.97700  1.000 20.11534  ?  397 TYR   B CD2  1 
ATOM   3914 C  CE1  . TYR   C 1 245 ? 29.96600  3.99500   36.43300  1.000 21.44876  ?  397 TYR   B CE1  1 
ATOM   3915 C  CE2  . TYR   C 1 245 ? 30.35100  6.35600   36.58300  1.000 22.00554  ?  397 TYR   B CE2  1 
ATOM   3916 C  CZ   . TYR   C 1 245 ? 29.51300  5.29500   36.31400  1.000 17.91532  ?  397 TYR   B CZ   1 
ATOM   3917 O  OH   . TYR   C 1 245 ? 28.21600  5.53100   35.92700  1.000 21.35149  ?  397 TYR   B OH   1 
ATOM   3918 N  N    . ARG   C 1 246 ? 34.99200  6.68500   35.70600  1.000 20.59753  ?  398 ARG   B N    1 
ATOM   3919 C  CA   . ARG   C 1 246 ? 34.96100  7.85500   34.83400  1.000 25.02855  ?  398 ARG   B CA   1 
ATOM   3920 C  C    . ARG   C 1 246 ? 35.55200  7.54300   33.46300  1.000 28.94726  ?  398 ARG   B C    1 
ATOM   3921 O  O    . ARG   C 1 246 ? 35.01400  7.97200   32.43500  1.000 28.03590  ?  398 ARG   B O    1 
ATOM   3922 C  CB   . ARG   C 1 246 ? 35.71200  9.00900   35.50100  1.000 33.46447  ?  398 ARG   B CB   1 
ATOM   3923 C  CG   . ARG   C 1 246 ? 35.82500  10.27400  34.67000  1.000 38.17787  ?  398 ARG   B CG   1 
ATOM   3924 C  CD   . ARG   C 1 246 ? 36.18100  11.47700  35.54300  1.000 58.33749  ?  398 ARG   B CD   1 
ATOM   3925 N  NE   . ARG   C 1 246 ? 35.90000  11.24900  36.96100  1.000 60.30797  ?  398 ARG   B NE   1 
ATOM   3926 C  CZ   . ARG   C 1 246 ? 36.83000  11.16200  37.90900  1.000 61.93975  ?  398 ARG   B CZ   1 
ATOM   3927 N  NH1  . ARG   C 1 246 ? 38.11400  11.28300  37.59600  1.000 52.78198  ?  398 ARG   B NH1  1 
ATOM   3928 N  NH2  . ARG   C 1 246 ? 36.47700  10.95300  39.17200  1.000 40.82503  ?  398 ARG   B NH2  1 
ATOM   3929 N  N    A SER   C 1 247 ? 36.65800  6.79500   33.42700  0.470 27.93358  ?  399 SER   B N    1 
ATOM   3930 N  N    B SER   C 1 247 ? 36.65400  6.79000   33.42800  0.530 27.91672  ?  399 SER   B N    1 
ATOM   3931 C  CA   A SER   C 1 247 ? 37.25300  6.42100   32.14800  0.470 26.33310  ?  399 SER   B CA   1 
ATOM   3932 C  CA   B SER   C 1 247 ? 37.25700  6.41800   32.15200  0.530 26.32934  ?  399 SER   B CA   1 
ATOM   3933 C  C    A SER   C 1 247 ? 36.35100  5.46400   31.37700  0.470 29.40476  ?  399 SER   B C    1 
ATOM   3934 C  C    B SER   C 1 247 ? 36.36500  5.45500   31.37700  0.530 29.42446  ?  399 SER   B C    1 
ATOM   3935 O  O    A SER   C 1 247 ? 36.18500  5.60400   30.16000  0.470 26.90420  ?  399 SER   B O    1 
ATOM   3936 O  O    B SER   C 1 247 ? 36.22000  5.58300   30.15500  0.530 26.90421  ?  399 SER   B O    1 
ATOM   3937 C  CB   A SER   C 1 247 ? 38.63000  5.79400   32.37000  0.470 26.27692  ?  399 SER   B CB   1 
ATOM   3938 C  CB   B SER   C 1 247 ? 38.63700  5.80200   32.38700  0.530 26.26195  ?  399 SER   B CB   1 
ATOM   3939 O  OG   A SER   C 1 247 ? 39.56100  6.75500   32.83600  0.470 26.87066  ?  399 SER   B OG   1 
ATOM   3940 O  OG   B SER   C 1 247 ? 39.05700  5.04200   31.26800  0.530 31.07864  ?  399 SER   B OG   1 
ATOM   3941 N  N    . LEU   C 1 248 ? 35.75800  4.48900   32.07000  1.000 23.24366  ?  400 LEU   B N    1 
ATOM   3942 C  CA   . LEU   C 1 248 ? 34.90000  3.51700   31.39900  1.000 24.28832  ?  400 LEU   B CA   1 
ATOM   3943 C  C    . LEU   C 1 248 ? 33.62400  4.16900   30.88000  1.000 29.07328  ?  400 LEU   B C    1 
ATOM   3944 O  O    . LEU   C 1 248 ? 33.26900  4.01500   29.70600  1.000 24.32526  ?  400 LEU   B O    1 
ATOM   3945 C  CB   . LEU   C 1 248 ? 34.56100  2.37200   32.35500  1.000 21.32243  ?  400 LEU   B CB   1 
ATOM   3946 C  CG   . LEU   C 1 248 ? 35.66700  1.35700   32.64900  1.000 33.40844  ?  400 LEU   B CG   1 
ATOM   3947 C  CD1  . LEU   C 1 248 ? 35.32100  0.53300   33.88400  1.000 26.00112  ?  400 LEU   B CD1  1 
ATOM   3948 C  CD2  . LEU   C 1 248 ? 35.90600  0.45400   31.44700  1.000 27.42982  ?  400 LEU   B CD2  1 
ATOM   3949 N  N    . SER   C 1 249 ? 32.92400  4.90900   31.74400  1.000 28.56550  ?  401 SER   B N    1 
ATOM   3950 C  CA   . SER   C 1 249 ? 31.63500  5.47900   31.36900  1.000 28.16143  ?  401 SER   B CA   1 
ATOM   3951 C  C    . SER   C 1 249 ? 31.76700  6.61100   30.36000  1.000 32.41175  ?  401 SER   B C    1 
ATOM   3952 O  O    . SER   C 1 249 ? 30.76400  6.99400   29.74700  1.000 33.18325  ?  401 SER   B O    1 
ATOM   3953 C  CB   . SER   C 1 249 ? 30.88900  5.96900   32.61500  1.000 20.84236  ?  401 SER   B CB   1 
ATOM   3954 O  OG   . SER   C 1 249 ? 31.52300  7.09800   33.18700  1.000 21.10317  ?  401 SER   B OG   1 
ATOM   3955 N  N    . PHE   C 1 250 ? 32.97500  7.15300   30.17500  1.000 30.90587  ?  402 PHE   B N    1 
ATOM   3956 C  CA   . PHE   C 1 250 ? 33.19300  8.16400   29.14400  1.000 38.92136  ?  402 PHE   B CA   1 
ATOM   3957 C  C    . PHE   C 1 250 ? 32.95400  7.59900   27.74800  1.000 35.09481  ?  402 PHE   B C    1 
ATOM   3958 O  O    . PHE   C 1 250 ? 32.57600  8.34000   26.83400  1.000 35.95999  ?  402 PHE   B O    1 
ATOM   3959 C  CB   . PHE   C 1 250 ? 34.61000  8.72700   29.26500  1.000 37.61531  ?  402 PHE   B CB   1 
ATOM   3960 C  CG   . PHE   C 1 250 ? 34.90200  9.87700   28.33800  1.000 43.61278  ?  402 PHE   B CG   1 
ATOM   3961 C  CD1  . PHE   C 1 250 ? 35.70400  9.69500   27.22100  1.000 41.99964  ?  402 PHE   B CD1  1 
ATOM   3962 C  CD2  . PHE   C 1 250 ? 34.39700  11.14200  28.59500  1.000 51.94054  ?  402 PHE   B CD2  1 
ATOM   3963 C  CE1  . PHE   C 1 250 ? 35.98700  10.74900  26.37000  1.000 57.03707  ?  402 PHE   B CE1  1 
ATOM   3964 C  CE2  . PHE   C 1 250 ? 34.67500  12.20300  27.74700  1.000 56.92592  ?  402 PHE   B CE2  1 
ATOM   3965 C  CZ   . PHE   C 1 250 ? 35.47100  12.00500  26.63300  1.000 48.34004  ?  402 PHE   B CZ   1 
ATOM   3966 N  N    . GLN   C 1 251 ? 33.16800  6.29600   27.56600  1.000 26.49679  ?  403 GLN   B N    1 
ATOM   3967 C  CA   . GLN   C 1 251 ? 32.88000  5.60900   26.31500  1.000 21.82637  ?  403 GLN   B CA   1 
ATOM   3968 C  C    . GLN   C 1 251 ? 31.38800  5.31200   26.22800  1.000 29.90972  ?  403 GLN   B C    1 
ATOM   3969 O  O    . GLN   C 1 251 ? 30.87700  4.48900   26.99900  1.000 24.19342  ?  403 GLN   B O    1 
ATOM   3970 C  CB   . GLN   C 1 251 ? 33.68000  4.31000   26.21700  1.000 25.51990  ?  403 GLN   B CB   1 
ATOM   3971 C  CG   . GLN   C 1 251 ? 35.17900  4.50300   26.32500  1.000 42.87291  ?  403 GLN   B CG   1 
ATOM   3972 C  CD   . GLN   C 1 251 ? 35.72100  5.41800   25.24900  1.000 42.60726  ?  403 GLN   B CD   1 
ATOM   3973 O  OE1  . GLN   C 1 251 ? 35.41300  5.25600   24.06800  1.000 53.92077  ?  403 GLN   B OE1  1 
ATOM   3974 N  NE2  . GLN   C 1 251 ? 36.53100  6.38900   25.65100  1.000 45.58097  ?  403 GLN   B NE2  1 
ATOM   3975 N  N    . PRO   C 1 252 ? 30.66000  5.95100   25.30800  1.000 31.89337  ?  404 PRO   B N    1 
ATOM   3976 C  CA   . PRO   C 1 252 ? 29.20400  5.74100   25.25000  1.000 27.02841  ?  404 PRO   B CA   1 
ATOM   3977 C  C    . PRO   C 1 252 ? 28.79400  4.28900   25.07300  1.000 23.59992  ?  404 PRO   B C    1 
ATOM   3978 O  O    . PRO   C 1 252 ? 27.75000  3.88800   25.60000  1.000 25.16901  ?  404 PRO   B O    1 
ATOM   3979 C  CB   . PRO   C 1 252 ? 28.78100  6.59900   24.05100  1.000 31.39723  ?  404 PRO   B CB   1 
ATOM   3980 C  CG   . PRO   C 1 252 ? 29.81600  7.67700   23.99200  1.000 32.62954  ?  404 PRO   B CG   1 
ATOM   3981 C  CD   . PRO   C 1 252 ? 31.10300  6.99300   24.36500  1.000 26.63517  ?  404 PRO   B CD   1 
ATOM   3982 N  N    . GLU   C 1 253 ? 29.57700  3.48500   24.35100  1.000 23.00869  ?  405 GLU   B N    1 
ATOM   3983 C  CA   . GLU   C 1 253 ? 29.24800  2.06900   24.22300  1.000 28.60016  ?  405 GLU   B CA   1 
ATOM   3984 C  C    . GLU   C 1 253 ? 29.34500  1.33500   25.55300  1.000 27.88738  ?  405 GLU   B C    1 
ATOM   3985 O  O    . GLU   C 1 253 ? 28.72600  0.27600   25.70700  1.000 24.89505  ?  405 GLU   B O    1 
ATOM   3986 C  CB   . GLU   C 1 253 ? 30.15600  1.39900   23.19100  1.000 34.10937  ?  405 GLU   B CB   1 
ATOM   3987 C  CG   . GLU   C 1 253 ? 31.62900  1.47500   23.52500  1.000 34.31427  ?  405 GLU   B CG   1 
ATOM   3988 C  CD   . GLU   C 1 253 ? 32.32600  2.61000   22.80600  1.000 33.66987  ?  405 GLU   B CD   1 
ATOM   3989 O  OE1  . GLU   C 1 253 ? 32.05800  3.78500   23.13800  1.000 37.32473  ?  405 GLU   B OE1  1 
ATOM   3990 O  OE2  . GLU   C 1 253 ? 33.14900  2.32800   21.91100  1.000 70.05598  ?  405 GLU   B OE2  1 
ATOM   3991 N  N    . ASN   C 1 254 ? 30.11100  1.86700   26.51000  1.000 25.90103  ?  406 ASN   B N    1 
ATOM   3992 C  CA   . ASN   C 1 254 ? 30.16400  1.28600   27.84700  1.000 27.47449  ?  406 ASN   B CA   1 
ATOM   3993 C  C    . ASN   C 1 254 ? 29.00000  1.76900   28.70300  1.000 25.33512  ?  406 ASN   B C    1 
ATOM   3994 O  O    . ASN   C 1 254 ? 28.32600  0.96400   29.35800  1.000 23.92962  ?  406 ASN   B O    1 
ATOM   3995 C  CB   . ASN   C 1 254 ? 31.49300  1.62600   28.52300  1.000 26.56036  ?  406 ASN   B CB   1 
ATOM   3996 C  CG   . ASN   C 1 254 ? 32.64900  0.81700   27.97700  1.000 30.29009  ?  406 ASN   B CG   1 
ATOM   3997 O  OD1  . ASN   C 1 254 ? 32.45800  -0.26600  27.42500  1.000 29.09803  ?  406 ASN   B OD1  1 
ATOM   3998 N  ND2  . ASN   C 1 254 ? 33.86100  1.33700   28.13600  1.000 26.84297  ?  406 ASN   B ND2  1 
ATOM   3999 N  N    A SER   C 1 255 ? 28.76300  3.08500   28.71400  0.600 22.93620  ?  407 SER   B N    1 
ATOM   4000 N  N    B SER   C 1 255 ? 28.74800  3.08200   28.71400  0.400 22.99174  ?  407 SER   B N    1 
ATOM   4001 C  CA   A SER   C 1 255 ? 27.63200  3.63800   29.45300  0.600 24.70777  ?  407 SER   B CA   1 
ATOM   4002 C  CA   B SER   C 1 255 ? 27.62200  3.60200   29.48500  0.400 24.68330  ?  407 SER   B CA   1 
ATOM   4003 C  C    A SER   C 1 255 ? 26.31600  3.03600   28.98500  0.600 23.94184  ?  407 SER   B C    1 
ATOM   4004 C  C    B SER   C 1 255 ? 26.29900  3.04400   28.97800  0.400 23.93064  ?  407 SER   B C    1 
ATOM   4005 O  O    A SER   C 1 255 ? 25.36600  2.93300   29.77100  0.600 23.62673  ?  407 SER   B O    1 
ATOM   4006 O  O    B SER   C 1 255 ? 25.32200  2.98000   29.73500  0.400 23.64124  ?  407 SER   B O    1 
ATOM   4007 C  CB   A SER   C 1 255 ? 27.60100  5.15900   29.30200  0.600 22.91620  ?  407 SER   B CB   1 
ATOM   4008 C  CB   B SER   C 1 255 ? 27.60900  5.13200   29.44400  0.400 22.92612  ?  407 SER   B CB   1 
ATOM   4009 O  OG   A SER   C 1 255 ? 28.58500  5.77900   30.10800  0.600 21.64103  ?  407 SER   B OG   1 
ATOM   4010 O  OG   B SER   C 1 255 ? 27.73200  5.61400   28.11800  0.400 26.69771  ?  407 SER   B OG   1 
ATOM   4011 N  N    A MET   C 1 256 ? 26.24500  2.63400   27.71300  0.600 21.79748  ?  408 MET   B N    1 
ATOM   4012 N  N    B MET   C 1 256 ? 26.25100  2.63400   27.70700  0.400 21.86831  ?  408 MET   B N    1 
ATOM   4013 C  CA   A MET   C 1 256 ? 25.06400  1.95100   27.19600  0.600 24.84773  ?  408 MET   B CA   1 
ATOM   4014 C  CA   B MET   C 1 256 ? 25.08000  1.94300   27.17700  0.400 24.82167  ?  408 MET   B CA   1 
ATOM   4015 C  C    A MET   C 1 256 ? 24.74900  0.68600   27.98100  0.600 21.00682  ?  408 MET   B C    1 
ATOM   4016 C  C    B MET   C 1 256 ? 24.75400  0.69100   27.97900  0.400 21.06592  ?  408 MET   B C    1 
ATOM   4017 O  O    A MET   C 1 256 ? 23.57700  0.32000   28.12200  0.600 21.67486  ?  408 MET   B O    1 
ATOM   4018 O  O    B MET   C 1 256 ? 23.57800  0.34000   28.13100  0.400 21.70194  ?  408 MET   B O    1 
ATOM   4019 C  CB   A MET   C 1 256 ? 25.26900  1.60200   25.72400  0.600 26.34038  ?  408 MET   B CB   1 
ATOM   4020 C  CB   B MET   C 1 256 ? 25.31000  1.56300   25.71500  0.400 26.35646  ?  408 MET   B CB   1 
ATOM   4021 C  CG   A MET   C 1 256 ? 24.45200  2.41900   24.75200  0.600 34.19381  ?  408 MET   B CG   1 
ATOM   4022 C  CG   B MET   C 1 256 ? 24.92600  2.62000   24.70200  0.400 31.47658  ?  408 MET   B CG   1 
ATOM   4023 S  SD   A MET   C 1 256 ? 24.74100  1.86700   23.06000  0.600 32.92376  ?  408 MET   B SD   1 
ATOM   4024 S  SD   B MET   C 1 256 ? 24.70500  1.91500   23.05500  0.400 32.85603  ?  408 MET   B SD   1 
ATOM   4025 C  CE   A MET   C 1 256 ? 26.15600  2.87000   22.61400  0.600 34.60682  ?  408 MET   B CE   1 
ATOM   4026 C  CE   B MET   C 1 256 ? 25.73400  0.45100   23.15700  0.400 26.77507  ?  408 MET   B CE   1 
ATOM   4027 N  N    . LYS   C 1 257 ? 25.77400  0.00100   28.48500  1.000 21.06569  ?  409 LYS   B N    1 
ATOM   4028 C  CA   . LYS   C 1 257 ? 25.59600  -1.26000  29.19100  1.000 19.33458  ?  409 LYS   B CA   1 
ATOM   4029 C  C    . LYS   C 1 257 ? 25.29200  -1.08600  30.67400  1.000 19.10608  ?  409 LYS   B C    1 
ATOM   4030 O  O    . LYS   C 1 257 ? 25.00000  -2.08000  31.35000  1.000 23.73436  ?  409 LYS   B O    1 
ATOM   4031 C  CB   . LYS   C 1 257 ? 26.85000  -2.12700  29.02700  1.000 27.06571  ?  409 LYS   B CB   1 
ATOM   4032 C  CG   . LYS   C 1 257 ? 27.17900  -2.45800  27.58000  1.000 29.72906  ?  409 LYS   B CG   1 
ATOM   4033 C  CD   . LYS   C 1 257 ? 26.10900  -3.35500  26.97700  1.000 43.47108  ?  409 LYS   B CD   1 
ATOM   4034 C  CE   . LYS   C 1 257 ? 26.28600  -3.50300  25.47400  1.000 48.50785  ?  409 LYS   B CE   1 
ATOM   4035 N  NZ   . LYS   C 1 257 ? 25.07600  -4.09100  24.83500  1.000 57.35772  ?  409 LYS   B NZ   1 
ATOM   4036 N  N    . LEU   C 1 258 ? 25.35000  0.13600   31.19200  1.000 14.85395  ?  410 LEU   B N    1 
ATOM   4037 C  CA   . LEU   C 1 258 ? 25.07600  0.38500   32.60000  1.000 20.92210  ?  410 LEU   B CA   1 
ATOM   4038 C  C    . LEU   C 1 258 ? 23.56400  0.43800   32.81200  1.000 21.33520  ?  410 LEU   B C    1 
ATOM   4039 O  O    . LEU   C 1 258 ? 22.77600  0.12300   31.91800  1.000 21.60524  ?  410 LEU   B O    1 
ATOM   4040 C  CB   . LEU   C 1 258 ? 25.77300  1.66500   33.05300  1.000 17.10411  ?  410 LEU   B CB   1 
ATOM   4041 C  CG   . LEU   C 1 258 ? 27.29400  1.65600   32.86900  1.000 27.50795  ?  410 LEU   B CG   1 
ATOM   4042 C  CD1  . LEU   C 1 258 ? 27.93700  2.91600   33.43900  1.000 23.81508  ?  410 LEU   B CD1  1 
ATOM   4043 C  CD2  . LEU   C 1 258 ? 27.89900  0.41100   33.50100  1.000 22.26268  ?  410 LEU   B CD2  1 
ATOM   4044 N  N    . THR   C 1 259 ? 23.14100  0.82400   34.00800  1.000 14.66158  ?  411 THR   B N    1 
ATOM   4045 C  CA   . THR   C 1 259 ? 21.73500  1.01200   34.31500  1.000 16.27755  ?  411 THR   B CA   1 
ATOM   4046 C  C    . THR   C 1 259 ? 21.46300  2.48300   34.59200  1.000 15.03180  ?  411 THR   B C    1 
ATOM   4047 O  O    . THR   C 1 259 ? 22.38700  3.24800   34.89000  1.000 20.76769  ?  411 THR   B O    1 
ATOM   4048 C  CB   . THR   C 1 259 ? 21.31100  0.18000   35.53500  1.000 18.28951  ?  411 THR   B CB   1 
ATOM   4049 O  OG1  . THR   C 1 259 ? 21.86300  0.76500   36.72000  1.000 19.19429  ?  411 THR   B OG1  1 
ATOM   4050 C  CG2  . THR   C 1 259 ? 21.79200  -1.25700  35.40500  1.000 18.66224  ?  411 THR   B CG2  1 
ATOM   4051 N  N    . PRO   C 1 260 ? 20.20300  2.91800   34.49800  1.000 17.42759  ?  412 PRO   B N    1 
ATOM   4052 C  CA   . PRO   C 1 260 ? 19.89800  4.31700   34.84200  1.000 18.69177  ?  412 PRO   B CA   1 
ATOM   4053 C  C    . PRO   C 1 260 ? 20.25100  4.67800   36.27400  1.000 18.15651  ?  412 PRO   B C    1 
ATOM   4054 O  O    . PRO   C 1 260 ? 20.73500  5.79100   36.52200  1.000 18.51849  ?  412 PRO   B O    1 
ATOM   4055 C  CB   . PRO   C 1 260 ? 18.38900  4.41100   34.58000  1.000 18.47179  ?  412 PRO   B CB   1 
ATOM   4056 C  CG   . PRO   C 1 260 ? 18.13600  3.38100   33.53000  1.000 25.69263  ?  412 PRO   B CG   1 
ATOM   4057 C  CD   . PRO   C 1 260 ? 19.05100  2.24200   33.87400  1.000 17.70265  ?  412 PRO   B CD   1 
ATOM   4058 N  N    . LEU   C 1 261 ? 20.02800  3.76800   37.22600  1.000 16.00030  ?  413 LEU   B N    1 
ATOM   4059 C  CA   . LEU   C 1 261 ? 20.35900  4.06700   38.61700  1.000 17.57572  ?  413 LEU   B CA   1 
ATOM   4060 C  C    . LEU   C 1 261 ? 21.86200  4.21800   38.80600  1.000 13.36351  ?  413 LEU   B C    1 
ATOM   4061 O  O    . LEU   C 1 261 ? 22.31400  5.08400   39.56300  1.000 16.92337  ?  413 LEU   B O    1 
ATOM   4062 C  CB   . LEU   C 1 261 ? 19.82200  2.97800   39.54200  1.000 17.76652  ?  413 LEU   B CB   1 
ATOM   4063 C  CG   . LEU   C 1 261 ? 20.04900  3.26500   41.02900  1.000 20.10756  ?  413 LEU   B CG   1 
ATOM   4064 C  CD1  . LEU   C 1 261 ? 19.37500  4.56900   41.43700  1.000 17.12901  ?  413 LEU   B CD1  1 
ATOM   4065 C  CD2  . LEU   C 1 261 ? 19.56400  2.11400   41.88600  1.000 18.88949  ?  413 LEU   B CD2  1 
ATOM   4066 N  N    . VAL   C 1 262 ? 22.65200  3.37700   38.13600  1.000 18.87879  ?  414 VAL   B N    1 
ATOM   4067 C  CA   . VAL   C 1 262 ? 24.10400  3.49600   38.23500  1.000 14.23384  ?  414 VAL   B CA   1 
ATOM   4068 C  C    . VAL   C 1 262 ? 24.56800  4.82500   37.65600  1.000 19.33330  ?  414 VAL   B C    1 
ATOM   4069 O  O    . VAL   C 1 262 ? 25.39000  5.52500   38.25800  1.000 16.72596  ?  414 VAL   B O    1 
ATOM   4070 C  CB   . VAL   C 1 262 ? 24.78800  2.30000   37.54800  1.000 12.69650  ?  414 VAL   B CB   1 
ATOM   4071 C  CG1  . VAL   C 1 262 ? 26.27300  2.57400   37.34100  1.000 17.41152  ?  414 VAL   B CG1  1 
ATOM   4072 C  CG2  . VAL   C 1 262 ? 24.59700  1.03500   38.39000  1.000 15.61767  ?  414 VAL   B CG2  1 
ATOM   4073 N  N    . LEU   C 1 263 ? 24.02900  5.21200   36.49500  1.000 14.85225  ?  415 LEU   B N    1 
ATOM   4074 C  CA   . LEU   C 1 263 ? 24.44100  6.47100   35.88000  1.000 15.70148  ?  415 LEU   B CA   1 
ATOM   4075 C  C    . LEU   C 1 263 ? 24.07300  7.66000   36.76000  1.000 19.27791  ?  415 LEU   B C    1 
ATOM   4076 O  O    . LEU   C 1 263 ? 24.84800  8.61500   36.88400  1.000 21.96799  ?  415 LEU   B O    1 
ATOM   4077 C  CB   . LEU   C 1 263 ? 23.81000  6.61400   34.49300  1.000 16.68278  ?  415 LEU   B CB   1 
ATOM   4078 C  CG   . LEU   C 1 263 ? 24.34900  5.68200   33.41000  1.000 20.74906  ?  415 LEU   B CG   1 
ATOM   4079 C  CD1  . LEU   C 1 263 ? 23.49900  5.77900   32.14800  1.000 24.52012  ?  415 LEU   B CD1  1 
ATOM   4080 C  CD2  . LEU   C 1 263 ? 25.81400  5.99300   33.10500  1.000 17.45022  ?  415 LEU   B CD2  1 
ATOM   4081 N  N    . GLU   C 1 264 ? 22.90100  7.61400   37.39000  1.000 17.38368  ?  416 GLU   B N    1 
ATOM   4082 C  CA   . GLU   C 1 264 ? 22.47700  8.72300   38.23800  1.000 19.93176  ?  416 GLU   B CA   1 
ATOM   4083 C  C    . GLU   C 1 264 ? 23.32300  8.81300   39.50300  1.000 28.42850  ?  416 GLU   B C    1 
ATOM   4084 O  O    . GLU   C 1 264 ? 23.81100  9.89300   39.85800  1.000 24.62133  ?  416 GLU   B O    1 
ATOM   4085 C  CB   . GLU   C 1 264 ? 20.99800  8.57400   38.59200  1.000 18.58359  ?  416 GLU   B CB   1 
ATOM   4086 C  CG   . GLU   C 1 264 ? 20.38100  9.82000   39.19500  1.000 24.21806  ?  416 GLU   B CG   1 
ATOM   4087 C  CD   . GLU   C 1 264 ? 19.02300  9.55400   39.81100  1.000 25.68043  ?  416 GLU   B CD   1 
ATOM   4088 O  OE1  . GLU   C 1 264 ? 18.96600  9.27400   41.02800  1.000 22.29115  ?  416 GLU   B OE1  1 
ATOM   4089 O  OE2  . GLU   C 1 264 ? 18.01200  9.62500   39.08100  1.000 24.25345  ?  416 GLU   B OE2  1 
ATOM   4090 N  N    . VAL   C 1 265 ? 23.51200  7.68800   40.19600  1.000 17.08482  ?  417 VAL   B N    1 
ATOM   4091 C  CA   . VAL   C 1 265 ? 24.16400  7.72400   41.50300  1.000 21.34731  ?  417 VAL   B CA   1 
ATOM   4092 C  C    . VAL   C 1 265 ? 25.67000  7.93300   41.37000  1.000 28.98250  ?  417 VAL   B C    1 
ATOM   4093 O  O    . VAL   C 1 265 ? 26.26800  8.70500   42.13000  1.000 22.55533  ?  417 VAL   B O    1 
ATOM   4094 C  CB   . VAL   C 1 265 ? 23.83200  6.44700   42.29500  1.000 27.17990  ?  417 VAL   B CB   1 
ATOM   4095 C  CG1  . VAL   C 1 265 ? 24.65800  6.38000   43.56900  1.000 27.15056  ?  417 VAL   B CG1  1 
ATOM   4096 C  CG2  . VAL   C 1 265 ? 22.34400  6.40400   42.62000  1.000 20.49045  ?  417 VAL   B CG2  1 
ATOM   4097 N  N    . PHE   C 1 266 ? 26.31100  7.25700   40.41900  1.000 18.77512  ?  418 PHE   B N    1 
ATOM   4098 C  CA   . PHE   C 1 266 ? 27.74800  7.40000   40.21800  1.000 23.18793  ?  418 PHE   B CA   1 
ATOM   4099 C  C    . PHE   C 1 266 ? 28.10700  8.60200   39.35500  1.000 28.68652  ?  418 PHE   B C    1 
ATOM   4100 O  O    . PHE   C 1 266 ? 29.28800  8.78500   39.04800  1.000 28.71317  ?  418 PHE   B O    1 
ATOM   4101 C  CB   . PHE   C 1 266 ? 28.33600  6.13900   39.57400  1.000 24.87527  ?  418 PHE   B CB   1 
ATOM   4102 C  CG   . PHE   C 1 266 ? 28.36600  4.93600   40.47900  1.000 18.92253  ?  418 PHE   B CG   1 
ATOM   4103 C  CD1  . PHE   C 1 266 ? 28.74300  3.69800   39.98000  1.000 21.82589  ?  418 PHE   B CD1  1 
ATOM   4104 C  CD2  . PHE   C 1 266 ? 28.01300  5.03400   41.81600  1.000 27.48165  ?  418 PHE   B CD2  1 
ATOM   4105 C  CE1  . PHE   C 1 266 ? 28.77500  2.58200   40.79600  1.000 24.85108  ?  418 PHE   B CE1  1 
ATOM   4106 C  CE2  . PHE   C 1 266 ? 28.04000  3.92000   42.63900  1.000 24.29602  ?  418 PHE   B CE2  1 
ATOM   4107 C  CZ   . PHE   C 1 266 ? 28.42300  2.69300   42.12800  1.000 24.90906  ?  418 PHE   B CZ   1 
ATOM   4108 N  N    . GLY   C 1 267 ? 27.12700  9.42200   38.96600  1.000 34.44844  ?  419 GLY   B N    1 
ATOM   4109 C  CA   . GLY   C 1 267 ? 27.33000  10.44400  37.96300  1.000 48.47931  ?  419 GLY   B CA   1 
ATOM   4110 C  C    . GLY   C 1 267 ? 27.63600  11.82500  38.53000  1.000 62.47824  ?  419 GLY   B C    1 
ATOM   4111 O  O    . GLY   C 1 267 ? 27.45200  12.10100  39.71300  1.000 51.11119  ?  419 GLY   B O    1 
ATOM   4112 N  N    . ASN   C 1 268 ? 28.10000  12.69500  37.63200  1.000 75.54143  ?  420 ASN   B N    1 
ATOM   4113 C  CA   . ASN   C 1 268 ? 28.53500  14.05400  37.95500  1.000 81.92778  ?  420 ASN   B CA   1 
ATOM   4114 C  C    . ASN   C 1 268 ? 29.66300  14.03000  38.98300  1.000 82.18366  ?  420 ASN   B C    1 
ATOM   4115 O  O    . ASN   C 1 268 ? 30.80800  14.35700  38.66600  1.000 85.00725  ?  420 ASN   B O    1 
ATOM   4116 C  CB   . ASN   C 1 268 ? 27.36600  14.90200  38.46500  1.000 83.21016  ?  420 ASN   B CB   1 
ATOM   4117 C  CG   . ASN   C 1 268 ? 27.55600  16.38400  38.19100  1.000 96.22821  ?  420 ASN   B CG   1 
ATOM   4118 O  OD1  . ASN   C 1 268 ? 26.59100  17.10700  37.94100  1.000 91.51623  ?  420 ASN   B OD1  1 
ATOM   4119 N  ND2  . ASN   C 1 268 ? 28.80100  16.84400  38.23300  1.000 106.13414 ?  420 ASN   B ND2  1 
ATOM   4120 N  N    . LYS   D 2 1   ? 22.34700  17.38500  38.40000  1.000 69.95546  ?  625 LYS   D N    1 
ATOM   4121 C  CA   . LYS   D 2 1   ? 21.89400  17.96700  39.65900  1.000 71.07813  ?  625 LYS   D CA   1 
ATOM   4122 C  C    . LYS   D 2 1   ? 20.70800  17.19400  40.22400  1.000 61.08494  ?  625 LYS   D C    1 
ATOM   4123 O  O    . LYS   D 2 1   ? 20.62200  16.96700  41.43100  1.000 64.71708  ?  625 LYS   D O    1 
ATOM   4124 C  CB   . LYS   D 2 1   ? 21.51600  19.43900  39.46400  1.000 76.39560  ?  625 LYS   D CB   1 
ATOM   4125 C  CG   . LYS   D 2 1   ? 21.57800  20.27200  40.73500  1.000 78.95321  ?  625 LYS   D CG   1 
ATOM   4126 C  CD   . LYS   D 2 1   ? 23.01500  20.59000  41.11600  1.000 71.16800  ?  625 LYS   D CD   1 
ATOM   4127 C  CE   . LYS   D 2 1   ? 23.30400  20.21700  42.56200  1.000 64.66963  ?  625 LYS   D CE   1 
ATOM   4128 N  NZ   . LYS   D 2 1   ? 22.27200  20.74800  43.49700  1.000 70.78740  ?  625 LYS   D NZ   1 
ATOM   4129 N  N    . ASN   D 2 2   ? 19.79600  16.79100  39.34400  1.000 58.47132  ?  626 ASN   D N    1 
ATOM   4130 C  CA   . ASN   D 2 2   ? 18.59000  16.09900  39.77100  1.000 59.15211  ?  626 ASN   D CA   1 
ATOM   4131 C  C    . ASN   D 2 2   ? 18.86100  14.61500  39.96900  1.000 34.61959  ?  626 ASN   D C    1 
ATOM   4132 O  O    . ASN   D 2 2   ? 19.58700  13.98900  39.19200  1.000 33.36941  ?  626 ASN   D O    1 
ATOM   4133 C  CB   . ASN   D 2 2   ? 17.47100  16.29400  38.74800  1.000 59.92662  ?  626 ASN   D CB   1 
ATOM   4134 C  CG   . ASN   D 2 2   ? 17.18300  17.75300  38.47400  1.000 71.87819  ?  626 ASN   D CG   1 
ATOM   4135 O  OD1  . ASN   D 2 2   ? 16.83700  18.12700  37.35500  1.000 82.01894  ?  626 ASN   D OD1  1 
ATOM   4136 N  ND2  . ASN   D 2 2   ? 17.32200  18.58800  39.49900  1.000 63.99521  ?  626 ASN   D ND2  1 
ATOM   4137 N  N    . HIS   D 2 3   ? 18.27000  14.05300  41.02000  1.000 29.66218  ?  627 HIS   D N    1 
ATOM   4138 C  CA   . HIS   D 2 3   ? 18.41400  12.63300  41.34200  1.000 31.83370  ?  627 HIS   D CA   1 
ATOM   4139 C  C    . HIS   D 2 3   ? 17.04400  12.01200  41.58500  1.000 22.82080  ?  627 HIS   D C    1 
ATOM   4140 O  O    . HIS   D 2 3   ? 16.76700  11.49000  42.66700  1.000 29.73595  ?  627 HIS   D O    1 
ATOM   4141 C  CB   . HIS   D 2 3   ? 19.32600  12.45300  42.55400  1.000 28.00036  ?  627 HIS   D CB   1 
ATOM   4142 C  CG   . HIS   D 2 3   ? 20.75100  12.80500  42.27900  1.000 28.19022  ?  627 HIS   D CG   1 
ATOM   4143 N  ND1  . HIS   D 2 3   ? 21.21800  14.10100  42.31300  1.000 26.90180  ?  627 HIS   D ND1  1 
ATOM   4144 C  CD2  . HIS   D 2 3   ? 21.80700  12.03300  41.93100  1.000 28.41296  ?  627 HIS   D CD2  1 
ATOM   4145 C  CE1  . HIS   D 2 3   ? 22.50400  14.11100  42.01000  1.000 22.52098  ?  627 HIS   D CE1  1 
ATOM   4146 N  NE2  . HIS   D 2 3   ? 22.88400  12.87000  41.76900  1.000 30.13602  ?  627 HIS   D NE2  1 
ATOM   4147 N  N    . PRO   D 2 4   ? 16.16400  12.03000  40.57900  1.000 27.06089  ?  628 PRO   D N    1 
ATOM   4148 C  CA   . PRO   D 2 4   ? 14.78400  11.57700  40.81600  1.000 24.81697  ?  628 PRO   D CA   1 
ATOM   4149 C  C    . PRO   D 2 4   ? 14.67500  10.11000  41.18900  1.000 25.29577  ?  628 PRO   D C    1 
ATOM   4150 O  O    . PRO   D 2 4   ? 13.81200  9.75200   42.00100  1.000 24.22211  ?  628 PRO   D O    1 
ATOM   4151 C  CB   . PRO   D 2 4   ? 14.08600  11.87800  39.48200  1.000 31.08633  ?  628 PRO   D CB   1 
ATOM   4152 C  CG   . PRO   D 2 4   ? 15.18000  11.86800  38.47100  1.000 24.36389  ?  628 PRO   D CG   1 
ATOM   4153 C  CD   . PRO   D 2 4   ? 16.39400  12.39800  39.16900  1.000 27.97898  ?  628 PRO   D CD   1 
ATOM   4154 N  N    . MET   D 2 5   ? 15.52200  9.24300   40.63100  1.000 21.91446  ?  629 MET   D N    1 
ATOM   4155 C  CA   . MET   D 2 5   ? 15.46200  7.83000   40.99400  1.000 23.13586  ?  629 MET   D CA   1 
ATOM   4156 C  C    . MET   D 2 5   ? 15.95500  7.61700   42.42000  1.000 22.87507  ?  629 MET   D C    1 
ATOM   4157 O  O    . MET   D 2 5   ? 15.31900  6.90700   43.20800  1.000 23.86557  ?  629 MET   D O    1 
ATOM   4158 C  CB   . MET   D 2 5   ? 16.27400  6.99400   40.00000  1.000 20.62719  ?  629 MET   D CB   1 
ATOM   4159 C  CG   . MET   D 2 5   ? 15.70400  7.00400   38.58300  1.000 27.40200  ?  629 MET   D CG   1 
ATOM   4160 S  SD   . MET   D 2 5   ? 16.77800  6.23600   37.34700  1.000 29.97490  ?  629 MET   D SD   1 
ATOM   4161 C  CE   . MET   D 2 5   ? 16.08300  6.90500   35.83900  1.000 35.04966  ?  629 MET   D CE   1 
ATOM   4162 N  N    . LEU   D 2 6   ? 17.08400  8.23900   42.77100  1.000 21.77105  ?  630 LEU   D N    1 
ATOM   4163 C  CA   . LEU   D 2 6   ? 17.57500  8.18300   44.14500  1.000 20.75323  ?  630 LEU   D CA   1 
ATOM   4164 C  C    . LEU   D 2 6   ? 16.57300  8.81100   45.10400  1.000 26.63651  ?  630 LEU   D C    1 
ATOM   4165 O  O    . LEU   D 2 6   ? 16.25100  8.23600   46.15100  1.000 24.30096  ?  630 LEU   D O    1 
ATOM   4166 C  CB   . LEU   D 2 6   ? 18.93200  8.88600   44.23900  1.000 23.66280  ?  630 LEU   D CB   1 
ATOM   4167 C  CG   . LEU   D 2 6   ? 19.68400  8.92400   45.56900  1.000 33.35753  ?  630 LEU   D CG   1 
ATOM   4168 C  CD1  . LEU   D 2 6   ? 19.68700  7.56300   46.23700  1.000 32.55989  ?  630 LEU   D CD1  1 
ATOM   4169 C  CD2  . LEU   D 2 6   ? 21.10900  9.41400   45.33700  1.000 22.63269  ?  630 LEU   D CD2  1 
ATOM   4170 N  N    . MET   D 2 7   ? 16.07000  9.99900   44.76000  1.000 24.82553  ?  631 MET   D N    1 
ATOM   4171 C  CA   . MET   D 2 7   ? 15.02700  10.62700  45.56200  1.000 23.20021  ?  631 MET   D CA   1 
ATOM   4172 C  C    . MET   D 2 7   ? 13.85600  9.67700   45.76800  1.000 23.22538  ?  631 MET   D C    1 
ATOM   4173 O  O    . MET   D 2 7   ? 13.41900  9.44900   46.90000  1.000 25.15511  ?  631 MET   D O    1 
ATOM   4174 C  CB   . MET   D 2 7   ? 14.56300  11.92100  44.89000  1.000 30.73087  ?  631 MET   D CB   1 
ATOM   4175 C  CG   . MET   D 2 7   ? 14.09400  13.02100  45.83900  1.000 47.93487  ?  631 MET   D CG   1 
ATOM   4176 S  SD   . MET   D 2 7   ? 15.27900  13.48600  47.12300  1.000 49.41321  ?  631 MET   D SD   1 
ATOM   4177 C  CE   . MET   D 2 7   ? 14.65200  12.56100  48.52600  1.000 38.55499  ?  631 MET   D CE   1 
ATOM   4178 N  N    . ASN   D 2 8   ? 13.35700  9.08400   44.67900  1.000 26.66198  ?  632 ASN   D N    1 
ATOM   4179 C  CA   . ASN   D 2 8   ? 12.20800  8.18600   44.77100  1.000 27.16404  ?  632 ASN   D CA   1 
ATOM   4180 C  C    . ASN   D 2 8   ? 12.47900  7.01400   45.70800  1.000 25.91929  ?  632 ASN   D C    1 
ATOM   4181 O  O    . ASN   D 2 8   ? 11.60100  6.61500   46.48100  1.000 22.47698  ?  632 ASN   D O    1 
ATOM   4182 C  CB   . ASN   D 2 8   ? 11.82900  7.67600   43.38200  1.000 18.83182  ?  632 ASN   D CB   1 
ATOM   4183 C  CG   . ASN   D 2 8   ? 10.71200  6.65600   43.42300  1.000 32.48351  ?  632 ASN   D CG   1 
ATOM   4184 O  OD1  . ASN   D 2 8   ? 10.94300  5.46000   43.24700  1.000 32.15718  ?  632 ASN   D OD1  1 
ATOM   4185 N  ND2  . ASN   D 2 8   ? 9.49100   7.12200   43.65800  1.000 31.41699  ?  632 ASN   D ND2  1 
ATOM   4186 N  N    . LEU   D 2 9   ? 13.68500  6.44000   45.64800  1.000 19.74824  ?  633 LEU   D N    1 
ATOM   4187 C  CA   . LEU   D 2 9   ? 14.00700  5.31500   46.52200  1.000 19.59138  ?  633 LEU   D CA   1 
ATOM   4188 C  C    . LEU   D 2 9   ? 14.13500  5.74900   47.97800  1.000 19.05760  ?  633 LEU   D C    1 
ATOM   4189 O  O    . LEU   D 2 9   ? 13.95400  4.92800   48.88400  1.000 23.75030  ?  633 LEU   D O    1 
ATOM   4190 C  CB   . LEU   D 2 9   ? 15.29500  4.63200   46.05500  1.000 20.78452  ?  633 LEU   D CB   1 
ATOM   4191 C  CG   . LEU   D 2 9   ? 15.22300  3.94300   44.68900  1.000 25.69183  ?  633 LEU   D CG   1 
ATOM   4192 C  CD1  . LEU   D 2 9   ? 16.59300  3.41900   44.26400  1.000 24.51601  ?  633 LEU   D CD1  1 
ATOM   4193 C  CD2  . LEU   D 2 9   ? 14.20500  2.81700   44.71300  1.000 20.36126  ?  633 LEU   D CD2  1 
ATOM   4194 N  N    . LEU   D 2 10  ? 14.43600  7.02600   48.22400  1.000 20.57036  ?  634 LEU   D N    1 
ATOM   4195 C  CA   . LEU   D 2 10  ? 14.50500  7.53500   49.58900  1.000 24.02263  ?  634 LEU   D CA   1 
ATOM   4196 C  C    . LEU   D 2 10  ? 13.13800  7.91300   50.15300  1.000 30.26860  ?  634 LEU   D C    1 
ATOM   4197 O  O    . LEU   D 2 10  ? 12.99200  7.97400   51.37700  1.000 28.73550  ?  634 LEU   D O    1 
ATOM   4198 C  CB   . LEU   D 2 10  ? 15.44200  8.74500   49.66000  1.000 24.22915  ?  634 LEU   D CB   1 
ATOM   4199 C  CG   . LEU   D 2 10  ? 16.94700  8.46200   49.65300  1.000 27.56931  ?  634 LEU   D CG   1 
ATOM   4200 C  CD1  . LEU   D 2 10  ? 17.72100  9.72900   49.32300  1.000 24.56808  ?  634 LEU   D CD1  1 
ATOM   4201 C  CD2  . LEU   D 2 10  ? 17.39300  7.88900   50.99000  1.000 21.90782  ?  634 LEU   D CD2  1 
ATOM   4202 N  N    . LYS   D 2 11  ? 12.14400  8.16800   49.30000  1.000 29.96555  ?  635 LYS   D N    1 
ATOM   4203 C  CA   . LYS   D 2 11  ? 10.77700  8.44600   49.75300  1.000 35.22836  ?  635 LYS   D CA   1 
ATOM   4204 C  C    . LYS   D 2 11  ? 9.96700   7.16200   49.91800  1.000 38.25734  ?  635 LYS   D C    1 
ATOM   4205 O  O    . LYS   D 2 11  ? 10.29300  6.31400   50.74900  1.000 51.53047  ?  635 LYS   D O    1 
ATOM   4206 C  CB   . LYS   D 2 11  ? 10.05700  9.38500   48.78200  1.000 32.52942  ?  635 LYS   D CB   1 
ATOM   4207 C  CG   . LYS   D 2 11  ? 10.94900  10.44800  48.18700  1.000 51.21710  ?  635 LYS   D CG   1 
ATOM   4208 C  CD   . LYS   D 2 11  ? 10.17700  11.49100  47.40300  1.000 51.58330  ?  635 LYS   D CD   1 
ATOM   4209 C  CE   . LYS   D 2 11  ? 9.66800   12.60700  48.29700  1.000 57.86159  ?  635 LYS   D CE   1 
ATOM   4210 N  NZ   . LYS   D 2 11  ? 9.75900   13.93400  47.61400  1.000 71.68601  ?  635 LYS   D NZ   1 
HETATM 4211 C  C10  . A1L7Z E 3 .   ? 7.13100   -2.03200  22.10700  1.000 33.85507  ?  501 A1L7Z A C10  1 
HETATM 4212 C  C13  . A1L7Z E 3 .   ? 7.56100   -4.57400  23.15500  1.000 32.93953  ?  501 A1L7Z A C13  1 
HETATM 4213 C  C15  . A1L7Z E 3 .   ? 6.18500   -7.39300  21.62900  1.000 41.15646  ?  501 A1L7Z A C15  1 
HETATM 4214 C  C20  . A1L7Z E 3 .   ? 14.64900  -8.40300  16.84800  1.000 51.38407  ?  501 A1L7Z A C20  1 
HETATM 4215 C  C21  . A1L7Z E 3 .   ? 15.50300  -8.97600  15.69500  1.000 46.62205  ?  501 A1L7Z A C21  1 
HETATM 4216 C  C22  . A1L7Z E 3 .   ? 16.81800  -8.20000  15.47900  1.000 60.73347  ?  501 A1L7Z A C22  1 
HETATM 4217 C  C24  . A1L7Z E 3 .   ? 8.13800   0.36300   26.09500  1.000 22.13629  ?  501 A1L7Z A C24  1 
HETATM 4218 C  C26  . A1L7Z E 3 .   ? 9.51000   0.85600   25.64000  1.000 20.66899  ?  501 A1L7Z A C26  1 
HETATM 4219 C  C28  . A1L7Z E 3 .   ? 10.61500  -0.08000  26.13300  1.000 18.86910  ?  501 A1L7Z A C28  1 
HETATM 4220 C  C01  . A1L7Z E 3 .   ? 10.64700  -5.89100  18.89300  1.000 29.91122  ?  501 A1L7Z A C01  1 
HETATM 4221 C  C02  . A1L7Z E 3 .   ? 10.68100  -7.14400  18.30200  1.000 32.90879  ?  501 A1L7Z A C02  1 
HETATM 4222 C  C03  . A1L7Z E 3 .   ? 9.57200   -7.96800  18.41100  1.000 31.17274  ?  501 A1L7Z A C03  1 
HETATM 4223 C  C04  . A1L7Z E 3 .   ? 8.44400   -7.60100  19.12400  1.000 30.29260  ?  501 A1L7Z A C04  1 
HETATM 4224 C  C05  . A1L7Z E 3 .   ? 8.40500   -6.35600  19.71300  1.000 25.59303  ?  501 A1L7Z A C05  1 
HETATM 4225 C  C06  . A1L7Z E 3 .   ? 9.49800   -5.49300  19.60300  1.000 29.34110  ?  501 A1L7Z A C06  1 
HETATM 4226 C  C08  . A1L7Z E 3 .   ? 7.13200   -4.41800  21.83800  1.000 32.58745  ?  501 A1L7Z A C08  1 
HETATM 4227 C  C09  . A1L7Z E 3 .   ? 6.91700   -3.14800  21.31100  1.000 36.15859  ?  501 A1L7Z A C09  1 
HETATM 4228 C  C11  . A1L7Z E 3 .   ? 7.55800   -2.16500  23.42400  1.000 26.55302  ?  501 A1L7Z A C11  1 
HETATM 4229 C  C12  . A1L7Z E 3 .   ? 7.77900   -3.43400  23.96100  1.000 24.93369  ?  501 A1L7Z A C12  1 
HETATM 4230 C  C14  . A1L7Z E 3 .   ? 5.51000   -5.37100  19.38400  1.000 35.31984  ?  501 A1L7Z A C14  1 
HETATM 4231 C  C18  . A1L7Z E 3 .   ? 12.83300  -6.67600  17.37500  1.000 48.38748  ?  501 A1L7Z A C18  1 
HETATM 4232 C  C19  . A1L7Z E 3 .   ? 13.90400  -7.15900  16.37400  1.000 58.94047  ?  501 A1L7Z A C19  1 
HETATM 4233 C  C23  . A1L7Z E 3 .   ? 7.86600   -1.06000  25.55100  1.000 22.68606  ?  501 A1L7Z A C23  1 
HETATM 4234 C  C25  . A1L7Z E 3 .   ? 8.06600   0.31400   27.62900  1.000 26.47280  ?  501 A1L7Z A C25  1 
HETATM 4235 C  C27  . A1L7Z E 3 .   ? 8.22500   1.71700   28.22000  1.000 23.17135  ?  501 A1L7Z A C27  1 
HETATM 4236 C  C31  . A1L7Z E 3 .   ? 9.62300   -9.33200  17.80800  1.000 36.40805  ?  501 A1L7Z A C31  1 
HETATM 4237 C  C32  . A1L7Z E 3 .   ? 6.88700   -0.65200  21.52900  1.000 36.83523  ?  501 A1L7Z A C32  1 
HETATM 4238 C  C35  . A1L7Z E 3 .   ? 5.38700   -0.36500  21.57200  1.000 37.39767  ?  501 A1L7Z A C35  1 
HETATM 4239 C  C36  . A1L7Z E 3 .   ? 10.18900  -10.03200 19.01500  1.000 41.21242  ?  501 A1L7Z A C36  1 
HETATM 4240 O  O16  . A1L7Z E 3 .   ? 7.76000   -0.96200  24.15900  1.000 24.15316  ?  501 A1L7Z A O16  1 
HETATM 4241 O  O17  . A1L7Z E 3 .   ? 11.80500  -7.62200  17.56800  1.000 40.49279  ?  501 A1L7Z A O17  1 
HETATM 4242 O  O29  . A1L7Z E 3 .   ? 7.17100   1.24200   25.59200  1.000 21.20300  ?  501 A1L7Z A O29  1 
HETATM 4243 O  O30  . A1L7Z E 3 .   ? 17.91500  -8.82100  15.39200  1.000 50.88582  ?  501 A1L7Z A O30  1 
HETATM 4244 O  O33  . A1L7Z E 3 .   ? 16.80700  -6.94300  15.37500  1.000 63.51215  -1 501 A1L7Z A O33  1 
HETATM 4245 O  O34  . A1L7Z E 3 .   ? 14.83900  -6.13500  16.25400  1.000 48.36339  ?  501 A1L7Z A O34  1 
HETATM 4246 SI SI07 . A1L7Z E 3 .   ? 6.80400   -5.89500  20.65900  1.000 32.03769  ?  501 A1L7Z A SI07 1 
HETATM 4247 C  C10  . A1L7Z F 3 .   ? 32.16600  -3.38800  41.68400  1.000 25.02908  ?  501 A1L7Z B C10  1 
HETATM 4248 C  C13  . A1L7Z F 3 .   ? 31.54200  -5.87300  40.58900  1.000 25.50509  ?  501 A1L7Z B C13  1 
HETATM 4249 C  C15  . A1L7Z F 3 .   ? 32.41700  -8.84200  42.09600  1.000 31.89971  ?  501 A1L7Z B C15  1 
HETATM 4250 C  C20  . A1L7Z F 3 .   ? 24.11500  -8.43700  47.17100  1.000 27.63900  ?  501 A1L7Z B C20  1 
HETATM 4251 C  C21  . A1L7Z F 3 .   ? 23.23700  -9.15500  48.21900  1.000 28.79978  ?  501 A1L7Z B C21  1 
HETATM 4252 C  C22  . A1L7Z F 3 .   ? 22.02000  -8.30800  48.64000  1.000 31.75700  ?  501 A1L7Z B C22  1 
HETATM 4253 C  C24  . A1L7Z F 3 .   ? 31.50300  -1.01900  37.57900  1.000 20.87892  ?  501 A1L7Z B C24  1 
HETATM 4254 C  C26  . A1L7Z F 3 .   ? 30.20400  -0.35600  38.03500  1.000 23.50831  ?  501 A1L7Z B C26  1 
HETATM 4255 C  C28  . A1L7Z F 3 .   ? 28.99000  -1.12000  37.51700  1.000 20.32553  ?  501 A1L7Z B C28  1 
HETATM 4256 C  C01  . A1L7Z F 3 .   ? 28.29700  -6.65400  44.98000  1.000 23.84750  ?  501 A1L7Z B C01  1 
HETATM 4257 C  C02  . A1L7Z F 3 .   ? 28.09600  -7.85700  45.63800  1.000 26.59949  ?  501 A1L7Z B C02  1 
HETATM 4258 C  C03  . A1L7Z F 3 .   ? 29.05800  -8.86200  45.53200  1.000 25.38105  ?  501 A1L7Z B C03  1 
HETATM 4259 C  C04  . A1L7Z F 3 .   ? 30.21100  -8.69800  44.77000  1.000 26.66038  ?  501 A1L7Z B C04  1 
HETATM 4260 C  C05  . A1L7Z F 3 .   ? 30.40900  -7.49900  44.11100  1.000 24.51471  ?  501 A1L7Z B C05  1 
HETATM 4261 C  C06  . A1L7Z F 3 .   ? 29.46400  -6.47500  44.21600  1.000 25.04192  ?  501 A1L7Z B C06  1 
HETATM 4262 C  C08  . A1L7Z F 3 .   ? 31.90800  -5.76400  41.92600  1.000 23.50188  ?  501 A1L7Z B C08  1 
HETATM 4263 C  C09  . A1L7Z F 3 .   ? 32.22500  -4.52500  42.48000  1.000 26.36665  ?  501 A1L7Z B C09  1 
HETATM 4264 C  C11  . A1L7Z F 3 .   ? 31.80200  -3.47800  40.34600  1.000 23.86549  ?  501 A1L7Z B C11  1 
HETATM 4265 C  C12  . A1L7Z F 3 .   ? 31.48500  -4.71700  39.78700  1.000 24.80179  ?  501 A1L7Z B C12  1 
HETATM 4266 C  C14  . A1L7Z F 3 .   ? 33.40400  -6.93500  44.32100  1.000 28.63265  ?  501 A1L7Z B C14  1 
HETATM 4267 C  C18  . A1L7Z F 3 .   ? 26.21100  -6.99800  46.91400  1.000 46.85471  ?  501 A1L7Z B C18  1 
HETATM 4268 C  C19  . A1L7Z F 3 .   ? 25.08800  -7.47800  47.86200  1.000 40.69588  ?  501 A1L7Z B C19  1 
HETATM 4269 C  C23  . A1L7Z F 3 .   ? 31.63400  -2.42900  38.20100  1.000 19.89552  ?  501 A1L7Z B C23  1 
HETATM 4270 C  C25  . A1L7Z F 3 .   ? 31.52500  -1.17500  36.05000  1.000 29.10080  ?  501 A1L7Z B C25  1 
HETATM 4271 C  C27  . A1L7Z F 3 .   ? 31.64200  0.19000   35.36800  1.000 24.71704  ?  501 A1L7Z B C27  1 
HETATM 4272 C  C31  . A1L7Z F 3 .   ? 28.81200  -10.16600 46.23600  1.000 38.15799  ?  501 A1L7Z B C31  1 
HETATM 4273 C  C32  . A1L7Z F 3 .   ? 32.51100  -2.04200  42.28300  1.000 37.76139  ?  501 A1L7Z B C32  1 
HETATM 4274 C  C35  . A1L7Z F 3 .   ? 34.03300  -1.90500  42.34500  1.000 38.96328  ?  501 A1L7Z B C35  1 
HETATM 4275 C  C36  . A1L7Z F 3 .   ? 27.65600  -10.73800 45.45300  1.000 40.83399  ?  501 A1L7Z B C36  1 
HETATM 4276 O  O16  . A1L7Z F 3 .   ? 31.76000  -2.27400  39.58500  1.000 19.07938  ?  501 A1L7Z B O16  1 
HETATM 4277 O  O17  . A1L7Z F 3 .   ? 26.93200  -8.10400  46.42600  1.000 30.58387  ?  501 A1L7Z B O17  1 
HETATM 4278 O  O29  . A1L7Z F 3 .   ? 32.56900  -0.22100  38.01800  1.000 16.96629  ?  501 A1L7Z B O29  1 
HETATM 4279 O  O30  . A1L7Z F 3 .   ? 22.15800  -7.08800  48.92600  1.000 27.28217  ?  501 A1L7Z B O30  1 
HETATM 4280 O  O33  . A1L7Z F 3 .   ? 20.87300  -8.83500  48.71700  1.000 24.87855  -1 501 A1L7Z B O33  1 
HETATM 4281 O  O34  . A1L7Z F 3 .   ? 24.37600  -6.36200  48.29900  1.000 31.63813  ?  501 A1L7Z B O34  1 
HETATM 4282 SI SI07 . A1L7Z F 3 .   ? 32.01700  -7.28700  43.08700  1.000 28.46514  ?  501 A1L7Z B SI07 1 
HETATM 4283 O  O    . HOH   G 4 .   ? 7.37000   15.66900  1.02100   1.000 39.93333  ?  601 HOH   A O    1 
HETATM 4284 O  O    . HOH   G 4 .   ? 24.45500  12.47000  -0.29100  1.000 33.05644  ?  602 HOH   A O    1 
HETATM 4285 O  O    . HOH   G 4 .   ? -9.528    0.493     27.210    1.000 41.62999  ?  603 HOH   A O    1 
HETATM 4286 O  O    . HOH   G 4 .   ? 2.60400   -20.39500 14.49900  1.000 49.20658  ?  604 HOH   A O    1 
HETATM 4287 O  O    . HOH   G 4 .   ? 17.01800  -3.84600  9.68000   1.000 30.07903  ?  605 HOH   A O    1 
HETATM 4288 O  O    . HOH   G 4 .   ? 28.75800  13.17300  4.75900   1.000 36.54675  ?  606 HOH   A O    1 
HETATM 4289 O  O    . HOH   G 4 .   ? -2.90600  10.31300  14.59800  1.000 49.25733  ?  607 HOH   A O    1 
HETATM 4290 O  O    . HOH   G 4 .   ? 22.79500  10.03200  27.19800  1.000 29.17469  ?  608 HOH   A O    1 
HETATM 4291 O  O    . HOH   G 4 .   ? 10.90600  21.18200  9.59900   1.000 38.99880  ?  609 HOH   A O    1 
HETATM 4292 O  O    . HOH   G 4 .   ? -3.11100  8.75700   20.74600  1.000 39.24768  ?  610 HOH   A O    1 
HETATM 4293 O  O    . HOH   G 4 .   ? 23.54700  -9.10700  28.14700  1.000 42.36454  ?  611 HOH   A O    1 
HETATM 4294 O  O    . HOH   G 4 .   ? 10.94300  -9.58200  13.95800  1.000 37.09185  ?  612 HOH   A O    1 
HETATM 4295 O  O    A HOH   G 4 .   ? 13.58900  -4.98700  -13.30800 0.570 23.40478  ?  613 HOH   A O    1 
HETATM 4296 O  O    B HOH   G 4 .   ? 15.41300  -5.48300  -13.00900 0.430 29.18582  ?  613 HOH   A O    1 
HETATM 4297 O  O    . HOH   G 4 .   ? 27.06700  -0.95400  -14.45900 1.000 43.97836  ?  614 HOH   A O    1 
HETATM 4298 O  O    . HOH   G 4 .   ? 4.422     16.595    10.842    1.000 29.93535  ?  615 HOH   A O    1 
HETATM 4299 O  O    . HOH   G 4 .   ? -1.75200  -12.06300 21.66300  1.000 40.31037  ?  616 HOH   A O    1 
HETATM 4300 O  O    . HOH   G 4 .   ? 12.97500  8.89900   28.14300  1.000 32.31612  ?  617 HOH   A O    1 
HETATM 4301 O  O    . HOH   G 4 .   ? 12.09300  10.05200  10.86600  1.000 20.31873  ?  618 HOH   A O    1 
HETATM 4302 O  O    . HOH   G 4 .   ? 21.09100  -1.23000  24.51700  1.000 27.37620  ?  619 HOH   A O    1 
HETATM 4303 O  O    . HOH   G 4 .   ? 6.19000   6.11300   -0.66400  1.000 36.23804  ?  620 HOH   A O    1 
HETATM 4304 O  O    . HOH   G 4 .   ? 12.33700  -9.39200  -6.13800  1.000 51.06524  ?  621 HOH   A O    1 
HETATM 4305 O  O    . HOH   G 4 .   ? -0.19200  -14.40300 32.53400  1.000 58.22213  ?  622 HOH   A O    1 
HETATM 4306 O  O    . HOH   G 4 .   ? 16.16300  5.63200   -11.77300 1.000 29.73742  ?  623 HOH   A O    1 
HETATM 4307 O  O    . HOH   G 4 .   ? 13.79900  -9.89300  34.34700  1.000 38.92401  ?  624 HOH   A O    1 
HETATM 4308 O  O    . HOH   G 4 .   ? 3.63200   -7.47800  35.78800  1.000 45.01124  ?  625 HOH   A O    1 
HETATM 4309 O  O    . HOH   G 4 .   ? 7.01000   13.19700  1.33900   1.000 41.94073  ?  626 HOH   A O    1 
HETATM 4310 O  O    . HOH   G 4 .   ? -5.79500  -5.41600  -3.92700  1.000 38.95853  ?  627 HOH   A O    1 
HETATM 4311 O  O    . HOH   G 4 .   ? 2.67600   15.04800  9.28400   1.000 48.61452  ?  628 HOH   A O    1 
HETATM 4312 O  O    . HOH   G 4 .   ? 24.09500  6.91200   4.62500   1.000 18.26599  ?  629 HOH   A O    1 
HETATM 4313 O  O    . HOH   G 4 .   ? 17.40600  22.17900  3.12200   1.000 37.14781  ?  630 HOH   A O    1 
HETATM 4314 O  O    . HOH   G 4 .   ? 9.91900   19.00200  9.11100   1.000 26.24225  ?  631 HOH   A O    1 
HETATM 4315 O  O    . HOH   G 4 .   ? 13.80200  24.47600  7.94900   1.000 42.16590  ?  632 HOH   A O    1 
HETATM 4316 O  O    . HOH   G 4 .   ? 10.52400  6.80700   18.14500  1.000 19.48425  ?  633 HOH   A O    1 
HETATM 4317 O  O    . HOH   G 4 .   ? -5.04400  4.51700   27.85700  1.000 59.22026  ?  634 HOH   A O    1 
HETATM 4318 O  O    . HOH   G 4 .   ? -4.90900  -2.68000  8.62900   1.000 48.91695  ?  635 HOH   A O    1 
HETATM 4319 O  O    . HOH   G 4 .   ? -3.21900  -0.55300  4.52700   1.000 32.92823  ?  636 HOH   A O    1 
HETATM 4320 O  O    . HOH   G 4 .   ? 11.14300  -8.79100  32.38300  1.000 22.54505  ?  637 HOH   A O    1 
HETATM 4321 O  O    . HOH   G 4 .   ? 7.15200   -4.26900  40.18900  1.000 39.70093  ?  638 HOH   A O    1 
HETATM 4322 O  O    . HOH   G 4 .   ? 17.32800  19.11000  13.37400  1.000 31.39035  ?  639 HOH   A O    1 
HETATM 4323 O  O    . HOH   G 4 .   ? 27.10200  13.40300  8.96000   1.000 40.85403  ?  640 HOH   A O    1 
HETATM 4324 O  O    . HOH   G 4 .   ? -4.21700  6.80300   26.13200  1.000 40.60088  ?  641 HOH   A O    1 
HETATM 4325 O  O    . HOH   G 4 .   ? 7.17200   7.11400   21.26700  1.000 32.55925  ?  642 HOH   A O    1 
HETATM 4326 O  O    . HOH   G 4 .   ? 24.31100  -1.58000  2.79400   1.000 20.62234  ?  643 HOH   A O    1 
HETATM 4327 O  O    . HOH   G 4 .   ? 25.13700  3.06800   1.97500   1.000 24.70985  ?  644 HOH   A O    1 
HETATM 4328 O  O    . HOH   G 4 .   ? 20.18100  -12.25800 17.96000  1.000 39.80988  ?  645 HOH   A O    1 
HETATM 4329 O  O    . HOH   G 4 .   ? -0.79700  -15.77800 27.69400  1.000 54.19333  ?  646 HOH   A O    1 
HETATM 4330 O  O    . HOH   G 4 .   ? 8.52300   10.50000  -0.83600  1.000 28.52674  ?  647 HOH   A O    1 
HETATM 4331 O  O    . HOH   G 4 .   ? 2.47600   -12.96600 5.15500   1.000 41.04398  ?  648 HOH   A O    1 
HETATM 4332 O  O    . HOH   G 4 .   ? 0.60100   -15.07100 10.07500  1.000 38.81814  ?  649 HOH   A O    1 
HETATM 4333 O  O    . HOH   G 4 .   ? 6.85100   -8.72100  7.77700   1.000 40.19586  ?  650 HOH   A O    1 
HETATM 4334 O  O    . HOH   G 4 .   ? -3.59600  5.31300   0.94100   1.000 40.84613  ?  651 HOH   A O    1 
HETATM 4335 O  O    . HOH   G 4 .   ? 20.067    20.609    10.980    1.000 35.64261  ?  652 HOH   A O    1 
HETATM 4336 O  O    . HOH   G 4 .   ? 9.47900   11.18000  26.17900  1.000 41.85380  ?  653 HOH   A O    1 
HETATM 4337 O  O    . HOH   G 4 .   ? 3.84400   -8.40100  4.94500   1.000 24.88538  ?  654 HOH   A O    1 
HETATM 4338 O  O    . HOH   G 4 .   ? 5.42900   6.90200   8.88200   1.000 32.84868  ?  655 HOH   A O    1 
HETATM 4339 O  O    . HOH   G 4 .   ? 19.75000  -3.49600  30.62100  1.000 33.57219  ?  656 HOH   A O    1 
HETATM 4340 O  O    . HOH   G 4 .   ? 22.74800  -6.69200  -1.66200  1.000 21.30081  ?  657 HOH   A O    1 
HETATM 4341 O  O    . HOH   G 4 .   ? 20.57600  18.03600  7.06200   1.000 22.72217  ?  658 HOH   A O    1 
HETATM 4342 O  O    . HOH   G 4 .   ? 17.75900  -1.99200  -15.87900 1.000 47.35150  ?  659 HOH   A O    1 
HETATM 4343 O  O    . HOH   G 4 .   ? 25.93900  -8.27700  0.85000   1.000 32.77483  ?  660 HOH   A O    1 
HETATM 4344 O  O    . HOH   G 4 .   ? 16.23800  -12.85900 28.14600  1.000 40.88580  ?  661 HOH   A O    1 
HETATM 4345 O  O    A HOH   G 4 .   ? 4.27200   -7.64700  -3.57300  0.690 21.46159  ?  662 HOH   A O    1 
HETATM 4346 O  O    B HOH   G 4 .   ? 2.71100   -8.93400  -3.03400  0.310 24.03124  ?  662 HOH   A O    1 
HETATM 4347 O  O    . HOH   G 4 .   ? -3.59600  0.40600   13.43400  1.000 38.90179  ?  663 HOH   A O    1 
HETATM 4348 O  O    . HOH   G 4 .   ? 5.78000   -11.69300 3.55600   1.000 35.18147  ?  664 HOH   A O    1 
HETATM 4349 O  O    . HOH   G 4 .   ? -2.91100  8.15200   18.25400  1.000 39.48464  ?  665 HOH   A O    1 
HETATM 4350 O  O    . HOH   G 4 .   ? 11.97600  -11.32800 -2.79700  1.000 43.05805  ?  666 HOH   A O    1 
HETATM 4351 O  O    . HOH   G 4 .   ? 13.01500  18.20100  -2.11300  1.000 27.14763  ?  667 HOH   A O    1 
HETATM 4352 O  O    . HOH   G 4 .   ? 6.38000   8.23500   7.14100   1.000 25.75945  ?  668 HOH   A O    1 
HETATM 4353 O  O    . HOH   G 4 .   ? -3.89300  -0.87400  10.78600  1.000 44.61998  ?  669 HOH   A O    1 
HETATM 4354 O  O    . HOH   G 4 .   ? 10.67600  10.64000  29.55900  1.000 48.73914  ?  670 HOH   A O    1 
HETATM 4355 O  O    . HOH   G 4 .   ? 10.95500  -11.71200 0.01600   1.000 30.38759  ?  671 HOH   A O    1 
HETATM 4356 O  O    . HOH   G 4 .   ? 1.08900   11.31900  28.64800  1.000 38.13035  ?  672 HOH   A O    1 
HETATM 4357 O  O    . HOH   G 4 .   ? -6.06900  2.42000   8.40000   1.000 47.62543  ?  673 HOH   A O    1 
HETATM 4358 O  O    . HOH   G 4 .   ? 18.56400  1.23000   37.06800  1.000 17.63293  ?  674 HOH   A O    1 
HETATM 4359 O  O    . HOH   G 4 .   ? 19.42600  10.73900  -8.23800  1.000 56.88850  ?  675 HOH   A O    1 
HETATM 4360 O  O    . HOH   G 4 .   ? 4.97700   -11.09100 -7.44500  1.000 42.63035  ?  676 HOH   A O    1 
HETATM 4361 O  O    . HOH   G 4 .   ? 12.64900  15.09100  -5.05900  1.000 45.80188  ?  677 HOH   A O    1 
HETATM 4362 O  O    . HOH   G 4 .   ? 24.03500  19.13100  13.33300  1.000 32.51672  ?  678 HOH   A O    1 
HETATM 4363 O  O    . HOH   G 4 .   ? 9.52300   21.47400  13.13100  1.000 35.07206  ?  679 HOH   A O    1 
HETATM 4364 O  O    . HOH   G 4 .   ? 25.50500  -14.84800 24.15100  1.000 59.12223  ?  680 HOH   A O    1 
HETATM 4365 O  O    . HOH   G 4 .   ? 6.27000   -11.09800 7.22300   1.000 47.84789  ?  681 HOH   A O    1 
HETATM 4366 O  O    . HOH   G 4 .   ? 24.461    -8.194    4.823     1.000 44.07729  ?  682 HOH   A O    1 
HETATM 4367 O  O    . HOH   G 4 .   ? 11.56300  9.81900   20.75700  1.000 32.47543  ?  683 HOH   A O    1 
HETATM 4368 O  O    . HOH   G 4 .   ? -6.07600  -0.00700  -1.94200  1.000 37.49104  ?  684 HOH   A O    1 
HETATM 4369 O  O    . HOH   G 4 .   ? 18.87500  7.95700   -2.41700  1.000 37.14593  ?  685 HOH   A O    1 
HETATM 4370 O  O    A HOH   G 4 .   ? 24.36100  -0.17200  15.16600  0.540 25.49469  ?  686 HOH   A O    1 
HETATM 4371 O  O    B HOH   G 4 .   ? 25.44700  0.91400   14.40900  0.460 27.48759  ?  686 HOH   A O    1 
HETATM 4372 O  O    . HOH   G 4 .   ? 19.88400  4.17100   -13.37800 1.000 24.85136  ?  687 HOH   A O    1 
HETATM 4373 O  O    A HOH   G 4 .   ? 29.89200  10.84900  2.23900   0.550 35.17900  ?  688 HOH   A O    1 
HETATM 4374 O  O    B HOH   G 4 .   ? 30.10200  8.75800   1.39600   0.450 36.72844  ?  688 HOH   A O    1 
HETATM 4375 O  O    . HOH   G 4 .   ? 19.33500  1.71800   -15.97000 1.000 42.72824  ?  689 HOH   A O    1 
HETATM 4376 O  O    . HOH   G 4 .   ? 19.74200  -4.61200  25.27300  1.000 37.19891  ?  690 HOH   A O    1 
HETATM 4377 O  O    . HOH   G 4 .   ? 28.40000  16.25500  14.68700  1.000 45.74029  ?  691 HOH   A O    1 
HETATM 4378 O  O    A HOH   G 4 .   ? 14.55900  22.57800  3.63900   0.650 21.62114  ?  692 HOH   A O    1 
HETATM 4379 O  O    B HOH   G 4 .   ? 13.32700  22.92600  4.65000   0.350 19.33561  ?  692 HOH   A O    1 
HETATM 4380 O  O    . HOH   G 4 .   ? 7.65300   9.85500   -5.11400  1.000 46.69970  ?  693 HOH   A O    1 
HETATM 4381 O  O    . HOH   G 4 .   ? 3.42300   -15.12000 26.71000  1.000 43.70994  ?  694 HOH   A O    1 
HETATM 4382 O  O    . HOH   G 4 .   ? 6.34300   12.21800  13.90600  1.000 39.28874  ?  695 HOH   A O    1 
HETATM 4383 O  O    . HOH   G 4 .   ? 23.37300  -9.47900  2.43500   1.000 30.20305  ?  696 HOH   A O    1 
HETATM 4384 O  O    A HOH   G 4 .   ? 16.05400  13.05400  -6.70200  0.550 28.06127  ?  697 HOH   A O    1 
HETATM 4385 O  O    B HOH   G 4 .   ? 14.58700  12.99600  -5.11500  0.450 23.65161  ?  697 HOH   A O    1 
HETATM 4386 O  O    . HOH   G 4 .   ? -1.51700  9.69200   10.91400  1.000 41.41420  ?  698 HOH   A O    1 
HETATM 4387 O  O    . HOH   G 4 .   ? 8.57600   8.05400   19.70300  1.000 36.36818  ?  699 HOH   A O    1 
HETATM 4388 O  O    . HOH   G 4 .   ? 22.65800  -9.80500  11.31700  1.000 55.93258  ?  700 HOH   A O    1 
HETATM 4389 O  O    . HOH   G 4 .   ? 1.484     -4.470    35.411    1.000 35.42768  ?  701 HOH   A O    1 
HETATM 4390 O  O    . HOH   G 4 .   ? 27.06200  8.92100   0.45300   1.000 51.20210  ?  702 HOH   A O    1 
HETATM 4391 O  O    . HOH   G 4 .   ? 18.07400  6.35900   -13.06100 1.000 45.21809  ?  703 HOH   A O    1 
HETATM 4392 O  O    . HOH   G 4 .   ? -5.34200  8.22200   24.36000  1.000 56.24796  ?  704 HOH   A O    1 
HETATM 4393 O  O    . HOH   G 4 .   ? 6.51300   11.38200  5.07100   1.000 29.45131  ?  705 HOH   A O    1 
HETATM 4394 O  O    . HOH   G 4 .   ? 25.52900  7.72800   1.87100   1.000 42.53533  ?  706 HOH   A O    1 
HETATM 4395 O  O    . HOH   G 4 .   ? 20.59800  8.26900   29.18800  1.000 34.98061  ?  707 HOH   A O    1 
HETATM 4396 O  O    . HOH   G 4 .   ? 10.20100  1.26200   -15.94900 1.000 50.98156  ?  708 HOH   A O    1 
HETATM 4397 O  O    . HOH   G 4 .   ? -3.38000  -5.24700  -1.94500  1.000 37.14243  ?  709 HOH   A O    1 
HETATM 4398 O  O    . HOH   G 4 .   ? 12.91900  9.79900   36.00000  1.000 43.31333  ?  710 HOH   A O    1 
HETATM 4399 O  O    . HOH   G 4 .   ? 20.213    -2.627    -15.388   1.000 39.41099  ?  711 HOH   A O    1 
HETATM 4400 O  O    . HOH   G 4 .   ? 16.11600  -11.57900 6.79000   1.000 51.13366  ?  712 HOH   A O    1 
HETATM 4401 O  O    . HOH   G 4 .   ? -1.97400  4.57900   -5.26900  1.000 45.81800  ?  713 HOH   A O    1 
HETATM 4402 O  O    . HOH   G 4 .   ? 0.20100   3.67900   30.61400  1.000 39.89290  ?  714 HOH   A O    1 
HETATM 4403 O  O    . HOH   G 4 .   ? 6.07600   -6.85100  6.40000   1.000 34.65996  ?  715 HOH   A O    1 
HETATM 4404 O  O    . HOH   G 4 .   ? 20.66600  11.91000  -6.50500  1.000 49.93551  ?  716 HOH   A O    1 
HETATM 4405 O  O    . HOH   G 4 .   ? 22.62200  5.63400   -4.51500  1.000 43.58717  ?  717 HOH   A O    1 
HETATM 4406 O  O    . HOH   G 4 .   ? 1.50100   8.30900   4.81200   1.000 40.37275  ?  718 HOH   A O    1 
HETATM 4407 O  O    . HOH   G 4 .   ? 4.620     14.805    13.105    1.000 34.60124  ?  719 HOH   A O    1 
HETATM 4408 O  O    . HOH   G 4 .   ? 22.71700  -15.32600 11.67600  1.000 52.82114  ?  720 HOH   A O    1 
HETATM 4409 O  O    . HOH   G 4 .   ? 20.790    22.273    9.038     1.000 31.84015  ?  721 HOH   A O    1 
HETATM 4410 O  O    . HOH   G 4 .   ? -3.64800  -3.39600  4.94000   1.000 65.62490  ?  722 HOH   A O    1 
HETATM 4411 O  O    A HOH   G 4 .   ? 2.79800   -2.90500  -14.98300 0.500 30.59865  ?  723 HOH   A O    1 
HETATM 4412 O  O    B HOH   G 4 .   ? 2.24900   -2.73700  -16.30800 0.500 32.75041  ?  723 HOH   A O    1 
HETATM 4413 O  O    A HOH   G 4 .   ? 10.25000  -6.09600  36.99500  0.530 27.55610  ?  724 HOH   A O    1 
HETATM 4414 O  O    B HOH   G 4 .   ? 8.96600   -4.85900  36.70000  0.470 31.01532  ?  724 HOH   A O    1 
HETATM 4415 O  O    . HOH   G 4 .   ? 18.60800  -5.60300  -6.25300  1.000 36.74459  ?  725 HOH   A O    1 
HETATM 4416 O  O    . HOH   G 4 .   ? 8.54200   8.92400   22.86700  1.000 40.12874  ?  726 HOH   A O    1 
HETATM 4417 O  O    A HOH   G 4 .   ? 2.74100   1.44500   -8.22100  0.530 21.94070  ?  727 HOH   A O    1 
HETATM 4418 O  O    B HOH   G 4 .   ? 1.15000   2.85900   -7.88000  0.470 21.12823  ?  727 HOH   A O    1 
HETATM 4419 O  O    . HOH   G 4 .   ? 4.35800   -11.03800 5.48000   1.000 29.09098  ?  728 HOH   A O    1 
HETATM 4420 O  O    . HOH   G 4 .   ? 3.78100   -7.07000  -14.24100 1.000 49.62116  ?  729 HOH   A O    1 
HETATM 4421 O  O    . HOH   G 4 .   ? 16.05000  16.69900  23.06500  1.000 47.01754  ?  730 HOH   A O    1 
HETATM 4422 O  O    . HOH   G 4 .   ? 30.17100  -5.39900  5.21300   1.000 85.47195  ?  731 HOH   A O    1 
HETATM 4423 O  O    . HOH   G 4 .   ? -3.34900  2.71200   14.02600  1.000 38.18698  ?  732 HOH   A O    1 
HETATM 4424 O  O    . HOH   G 4 .   ? -7.45900  -6.00400  17.02900  1.000 51.94872  ?  733 HOH   A O    1 
HETATM 4425 O  O    . HOH   G 4 .   ? 5.32200   8.21200   0.86300   1.000 43.88050  ?  734 HOH   A O    1 
HETATM 4426 O  O    . HOH   G 4 .   ? -6.71600  -0.89100  -14.51500 1.000 44.05731  ?  735 HOH   A O    1 
HETATM 4427 O  O    . HOH   G 4 .   ? 2.55400   9.66700   6.74900   1.000 38.60390  ?  736 HOH   A O    1 
HETATM 4428 O  O    A HOH   G 4 .   ? -8.87200  -3.20800  -2.89300  0.590 26.31087  ?  737 HOH   A O    1 
HETATM 4429 O  O    B HOH   G 4 .   ? -9.53200  -2.41800  -1.31200  0.410 29.83088  ?  737 HOH   A O    1 
HETATM 4430 O  O    . HOH   G 4 .   ? 22.126    13.741    0.211     1.000 27.19953  ?  738 HOH   A O    1 
HETATM 4431 O  O    A HOH   G 4 .   ? -3.71000  4.19300   16.75000  0.640 27.35166  ?  739 HOH   A O    1 
HETATM 4432 O  O    B HOH   G 4 .   ? -4.37800  5.09400   18.59100  0.360 23.06787  ?  739 HOH   A O    1 
HETATM 4433 O  O    A HOH   G 4 .   ? 24.15400  3.28600   -11.09600 0.480 36.04711  ?  740 HOH   A O    1 
HETATM 4434 O  O    B HOH   G 4 .   ? 24.61600  2.20300   -9.63700  0.520 37.34321  ?  740 HOH   A O    1 
HETATM 4435 O  O    . HOH   G 4 .   ? -4.34800  -12.11500 21.78100  1.000 47.91416  ?  741 HOH   A O    1 
HETATM 4436 O  O    . HOH   G 4 .   ? -5.54600  0.01200   4.16900   1.000 44.95126  ?  742 HOH   A O    1 
HETATM 4437 O  O    . HOH   G 4 .   ? 18.15000  -19.87200 23.02900  1.000 65.85963  ?  743 HOH   A O    1 
HETATM 4438 O  O    . HOH   G 4 .   ? 18.41200  5.24300   -15.52600 1.000 57.99085  ?  744 HOH   A O    1 
HETATM 4439 O  O    A HOH   G 4 .   ? 18.09700  22.90700  0.96100   0.590 30.32070  ?  745 HOH   A O    1 
HETATM 4440 O  O    B HOH   G 4 .   ? 18.10100  24.14500  2.02000   0.410 27.49585  ?  745 HOH   A O    1 
HETATM 4441 O  O    . HOH   G 4 .   ? 26.10200  0.12700   1.47800   1.000 23.46894  ?  746 HOH   A O    1 
HETATM 4442 O  O    . HOH   H 4 .   ? 29.34000  10.40600  21.27300  1.000 32.87378  ?  701 HOH   C O    1 
HETATM 4443 O  O    . HOH   I 4 .   ? 39.76300  -14.36700 42.43200  1.000 37.83375  ?  601 HOH   B O    1 
HETATM 4444 O  O    A HOH   I 4 .   ? 34.69000  -8.74600  68.09500  0.570 24.72377  ?  602 HOH   B O    1 
HETATM 4445 O  O    B HOH   I 4 .   ? 36.01000  -9.74200  67.17400  0.430 29.50272  ?  602 HOH   B O    1 
HETATM 4446 O  O    . HOH   I 4 .   ? 12.62500  12.74900  59.36000  1.000 36.91350  ?  603 HOH   B O    1 
HETATM 4447 O  O    . HOH   I 4 .   ? 29.80500  -5.52100  27.58100  1.000 36.36611  ?  604 HOH   B O    1 
HETATM 4448 O  O    . HOH   I 4 .   ? 27.51500  7.87900   35.81000  1.000 30.80311  ?  605 HOH   B O    1 
HETATM 4449 O  O    . HOH   I 4 .   ? 44.54700  1.02700   35.65500  1.000 39.93103  ?  606 HOH   B O    1 
HETATM 4450 O  O    . HOH   I 4 .   ? 28.53800  14.23700  68.81400  1.000 39.55375  ?  607 HOH   B O    1 
HETATM 4451 O  O    . HOH   I 4 .   ? 36.90000  14.55600  53.82300  1.000 38.26458  ?  608 HOH   B O    1 
HETATM 4452 O  O    . HOH   I 4 .   ? 10.71300  -4.03200  61.44600  1.000 39.63648  ?  609 HOH   B O    1 
HETATM 4453 O  O    . HOH   I 4 .   ? 28.61800  8.91700   53.07800  1.000 17.15092  ?  610 HOH   B O    1 
HETATM 4454 O  O    . HOH   I 4 .   ? 28.40300  17.33700  66.00900  1.000 39.24139  ?  611 HOH   B O    1 
HETATM 4455 O  O    . HOH   I 4 .   ? 39.42400  9.48700   41.91900  1.000 45.73436  ?  612 HOH   B O    1 
HETATM 4456 O  O    . HOH   I 4 .   ? 18.37300  -0.92200  39.27700  1.000 33.68978  ?  613 HOH   B O    1 
HETATM 4457 O  O    . HOH   I 4 .   ? 18.20100  10.30500  36.62000  1.000 30.00177  ?  614 HOH   B O    1 
HETATM 4458 O  O    . HOH   I 4 .   ? 27.11400  -8.05600  53.92600  1.000 20.95349  ?  615 HOH   B O    1 
HETATM 4459 O  O    A HOH   I 4 .   ? 29.14000  -22.80900 43.38500  0.430 51.87650  ?  616 HOH   B O    1 
HETATM 4460 O  O    B HOH   I 4 .   ? 29.78500  -22.60200 44.48200  0.570 54.51014  ?  616 HOH   B O    1 
HETATM 4461 O  O    . HOH   I 4 .   ? 34.26700  10.05900  58.81100  1.000 29.44537  ?  617 HOH   B O    1 
HETATM 4462 O  O    . HOH   I 4 .   ? 17.23100  -6.74500  65.63000  1.000 26.35088  ?  618 HOH   B O    1 
HETATM 4463 O  O    . HOH   I 4 .   ? 21.52300  -16.17600 34.87300  1.000 48.44334  ?  619 HOH   B O    1 
HETATM 4464 O  O    . HOH   I 4 .   ? 24.21600  5.34600   75.69000  1.000 34.93886  ?  620 HOH   B O    1 
HETATM 4465 O  O    . HOH   I 4 .   ? 14.05500  -8.44100  62.87900  1.000 43.79847  ?  621 HOH   B O    1 
HETATM 4466 O  O    . HOH   I 4 .   ? 19.58000  -3.73500  33.41100  1.000 33.22496  ?  622 HOH   B O    1 
HETATM 4467 O  O    . HOH   I 4 .   ? 14.34200  9.52300   53.49300  1.000 29.26959  ?  623 HOH   B O    1 
HETATM 4468 O  O    . HOH   I 4 .   ? 20.76700  17.77500  56.79500  1.000 24.97487  ?  624 HOH   B O    1 
HETATM 4469 O  O    . HOH   I 4 .   ? 27.20900  -10.01400 31.36700  1.000 24.50129  ?  625 HOH   B O    1 
HETATM 4470 O  O    . HOH   I 4 .   ? 31.77000  19.11900  66.65600  1.000 51.95690  ?  626 HOH   B O    1 
HETATM 4471 O  O    . HOH   I 4 .   ? 22.633    14.578    69.152    1.000 43.35600  ?  627 HOH   B O    1 
HETATM 4472 O  O    . HOH   I 4 .   ? 16.49500  6.80900   59.36700  1.000 20.41500  ?  628 HOH   B O    1 
HETATM 4473 O  O    . HOH   I 4 .   ? 45.56300  5.45700   39.86600  1.000 45.51327  ?  629 HOH   B O    1 
HETATM 4474 O  O    . HOH   I 4 .   ? 43.16600  -3.07400  53.06200  1.000 44.28530  ?  630 HOH   B O    1 
HETATM 4475 O  O    . HOH   I 4 .   ? 24.07100  18.58200  50.86100  1.000 37.16940  ?  631 HOH   B O    1 
HETATM 4476 O  O    . HOH   I 4 .   ? 29.76000  5.83900   45.68800  1.000 21.54118  ?  632 HOH   B O    1 
HETATM 4477 O  O    . HOH   I 4 .   ? 19.56300  -14.10500 33.88100  1.000 41.32228  ?  633 HOH   B O    1 
HETATM 4478 O  O    . HOH   I 4 .   ? 45.14500  -7.67300  68.43400  1.000 40.87601  ?  634 HOH   B O    1 
HETATM 4479 O  O    . HOH   I 4 .   ? 20.66300  -11.08900 47.27600  1.000 34.00753  ?  635 HOH   B O    1 
HETATM 4480 O  O    . HOH   I 4 .   ? 17.03400  -8.43600  50.80300  1.000 30.69872  ?  636 HOH   B O    1 
HETATM 4481 O  O    . HOH   I 4 .   ? 33.59400  5.63200   42.74900  0.820 28.39788  ?  637 HOH   B O    1 
HETATM 4482 O  O    . HOH   I 4 .   ? 33.46400  12.85700  65.75200  1.000 39.93349  ?  638 HOH   B O    1 
HETATM 4483 O  O    . HOH   I 4 .   ? 33.79800  7.00900   56.24200  1.000 27.71618  ?  639 HOH   B O    1 
HETATM 4484 O  O    . HOH   I 4 .   ? 35.84600  -14.94700 34.07700  1.000 46.12488  ?  640 HOH   B O    1 
HETATM 4485 O  O    . HOH   I 4 .   ? 21.44700  1.21400   26.73000  1.000 17.39256  ?  641 HOH   B O    1 
HETATM 4486 O  O    . HOH   I 4 .   ? 15.11000  3.04500   61.86900  1.000 29.01394  ?  642 HOH   B O    1 
HETATM 4487 O  O    . HOH   I 4 .   ? 35.14800  -9.88800  59.00100  1.000 26.50554  ?  643 HOH   B O    1 
HETATM 4488 O  O    . HOH   I 4 .   ? 22.36500  21.03200  50.13800  1.000 42.84863  ?  644 HOH   B O    1 
HETATM 4489 O  O    . HOH   I 4 .   ? 22.40100  -4.51100  54.03500  1.000 24.84419  ?  645 HOH   B O    1 
HETATM 4490 O  O    . HOH   I 4 .   ? 14.44900  -1.00900  45.73100  1.000 37.09933  ?  646 HOH   B O    1 
HETATM 4491 O  O    . HOH   I 4 .   ? 43.18900  5.75100   45.27900  1.000 38.88977  ?  647 HOH   B O    1 
HETATM 4492 O  O    . HOH   I 4 .   ? 30.75900  20.08600  54.76000  1.000 49.91732  ?  648 HOH   B O    1 
HETATM 4493 O  O    . HOH   I 4 .   ? 35.08000  5.53000   54.52700  1.000 24.21135  ?  649 HOH   B O    1 
HETATM 4494 O  O    . HOH   I 4 .   ? 28.87100  8.92600   43.06000  1.000 29.29982  ?  650 HOH   B O    1 
HETATM 4495 O  O    . HOH   I 4 .   ? 44.97900  -4.93500  34.88500  1.000 33.48838  ?  651 HOH   B O    1 
HETATM 4496 O  O    . HOH   I 4 .   ? 37.89600  6.53600   28.13300  1.000 44.20975  ?  652 HOH   B O    1 
HETATM 4497 O  O    . HOH   I 4 .   ? 15.32500  -1.73200  61.83500  1.000 36.04777  ?  653 HOH   B O    1 
HETATM 4498 O  O    . HOH   I 4 .   ? 43.68500  1.60800   46.68000  1.000 35.92671  ?  654 HOH   B O    1 
HETATM 4499 O  O    . HOH   I 4 .   ? 15.89600  -9.20600  61.56500  1.000 37.59754  ?  655 HOH   B O    1 
HETATM 4500 O  O    . HOH   I 4 .   ? 21.06400  20.52900  53.20700  1.000 41.25282  ?  656 HOH   B O    1 
HETATM 4501 O  O    . HOH   I 4 .   ? 24.63000  -11.96400 69.02500  1.000 47.28188  ?  657 HOH   B O    1 
HETATM 4502 O  O    . HOH   I 4 .   ? 24.55100  -10.94700 29.11900  1.000 40.67735  ?  658 HOH   B O    1 
HETATM 4503 O  O    A HOH   I 4 .   ? 34.52300  11.24000  61.63100  0.600 26.72789  ?  659 HOH   B O    1 
HETATM 4504 O  O    B HOH   I 4 .   ? 35.16100  12.00300  59.98700  0.400 22.61928  ?  659 HOH   B O    1 
HETATM 4505 O  O    . HOH   I 4 .   ? 18.48400  -12.04800 46.14200  1.000 33.82042  ?  660 HOH   B O    1 
HETATM 4506 O  O    . HOH   I 4 .   ? 21.88000  -13.77400 35.95000  1.000 29.73716  ?  661 HOH   B O    1 
HETATM 4507 O  O    . HOH   I 4 .   ? 26.02500  -5.63300  77.54300  1.000 42.66169  ?  662 HOH   B O    1 
HETATM 4508 O  O    . HOH   I 4 .   ? 34.80200  -13.37300 68.72400  1.000 49.06691  ?  663 HOH   B O    1 
HETATM 4509 O  O    . HOH   I 4 .   ? 14.30500  0.92300   54.04500  1.000 31.87803  ?  664 HOH   B O    1 
HETATM 4510 O  O    . HOH   I 4 .   ? 32.18600  9.25000   64.76300  1.000 27.42715  ?  665 HOH   B O    1 
HETATM 4511 O  O    . HOH   I 4 .   ? 21.73900  -1.33600  29.67500  1.000 42.70414  ?  666 HOH   B O    1 
HETATM 4512 O  O    . HOH   I 4 .   ? 14.01000  1.37700   80.67600  1.000 62.04209  ?  667 HOH   B O    1 
HETATM 4513 O  O    . HOH   I 4 .   ? 43.26100  6.44100   42.97400  1.000 37.53739  ?  668 HOH   B O    1 
HETATM 4514 O  O    . HOH   I 4 .   ? 13.74600  15.44400  53.73700  1.000 48.44164  ?  669 HOH   B O    1 
HETATM 4515 O  O    . HOH   I 4 .   ? 48.62400  -1.55700  71.09300  1.000 40.63045  ?  670 HOH   B O    1 
HETATM 4516 O  O    . HOH   I 4 .   ? 13.25200  12.56100  54.92700  1.000 43.30152  ?  671 HOH   B O    1 
HETATM 4517 O  O    . HOH   I 4 .   ? 25.82400  12.52600  69.35700  1.000 34.24078  ?  672 HOH   B O    1 
HETATM 4518 O  O    . HOH   I 4 .   ? 22.86200  -19.17600 43.60200  1.000 55.30793  ?  673 HOH   B O    1 
HETATM 4519 O  O    . HOH   I 4 .   ? 32.54500  -11.65000 56.28400  1.000 37.71226  ?  674 HOH   B O    1 
HETATM 4520 O  O    . HOH   I 4 .   ? 15.23300  -17.66100 48.35900  1.000 46.54861  ?  675 HOH   B O    1 
HETATM 4521 O  O    . HOH   I 4 .   ? 32.03500  20.21300  51.03400  1.000 39.25633  ?  676 HOH   B O    1 
HETATM 4522 O  O    . HOH   I 4 .   ? 37.96800  10.84600  51.47100  1.000 38.67809  ?  677 HOH   B O    1 
HETATM 4523 O  O    . HOH   I 4 .   ? 32.94200  10.07800  32.21900  1.000 52.43300  ?  678 HOH   B O    1 
HETATM 4524 O  O    . HOH   I 4 .   ? 27.91900  -12.62400 64.32800  1.000 39.95128  ?  679 HOH   B O    1 
HETATM 4525 O  O    . HOH   I 4 .   ? 14.82900  -5.00900  50.69600  1.000 43.19273  ?  680 HOH   B O    1 
HETATM 4526 O  O    . HOH   I 4 .   ? 17.37800  19.19500  50.81600  1.000 29.04358  ?  681 HOH   B O    1 
HETATM 4527 O  O    . HOH   I 4 .   ? 22.93200  -11.81600 56.95600  1.000 38.22794  ?  682 HOH   B O    1 
HETATM 4528 O  O    . HOH   I 4 .   ? 34.58700  10.57300  49.83700  1.000 32.71919  ?  683 HOH   B O    1 
HETATM 4529 O  O    . HOH   I 4 .   ? 20.52200  4.24300   77.26000  1.000 33.32053  ?  684 HOH   B O    1 
HETATM 4530 O  O    A HOH   I 4 .   ? 16.27100  -9.83900  52.75100  0.650 24.00705  ?  685 HOH   B O    1 
HETATM 4531 O  O    B HOH   I 4 .   ? 15.11300  -11.07400 51.91700  0.350 19.29426  ?  685 HOH   B O    1 
HETATM 4532 O  O    . HOH   I 4 .   ? 20.43800  -10.97900 56.27200  1.000 36.89273  ?  686 HOH   B O    1 
HETATM 4533 O  O    . HOH   I 4 .   ? 34.32500  -17.35700 37.59500  1.000 50.23753  ?  687 HOH   B O    1 
HETATM 4534 O  O    . HOH   I 4 .   ? 22.11000  -5.09800  27.63800  1.000 46.27193  ?  688 HOH   B O    1 
HETATM 4535 O  O    . HOH   I 4 .   ? 40.07600  -11.12600 73.47200  1.000 49.44461  ?  689 HOH   B O    1 
HETATM 4536 O  O    . HOH   I 4 .   ? 11.329    11.070    62.548    1.000 42.90838  ?  690 HOH   B O    1 
HETATM 4537 O  O    . HOH   I 4 .   ? 36.48800  13.49800  51.55700  1.000 42.39349  ?  691 HOH   B O    1 
HETATM 4538 O  O    . HOH   I 4 .   ? 19.46100  -4.61800  38.63300  1.000 32.39146  ?  692 HOH   B O    1 
HETATM 4539 O  O    . HOH   I 4 .   ? 36.12100  -14.84700 58.68200  1.000 43.00791  ?  693 HOH   B O    1 
HETATM 4540 O  O    A HOH   I 4 .   ? 19.96300  8.07300   34.62200  0.490 24.11123  ?  694 HOH   B O    1 
HETATM 4541 O  O    B HOH   I 4 .   ? 20.21100  8.06000   32.56000  0.510 25.92789  ?  694 HOH   B O    1 
HETATM 4542 O  O    . HOH   I 4 .   ? 14.68100  -8.21500  35.55100  1.000 34.35611  ?  695 HOH   B O    1 
HETATM 4543 O  O    . HOH   I 4 .   ? 36.67600  -17.45200 53.95100  1.000 36.69442  ?  696 HOH   B O    1 
HETATM 4544 O  O    . HOH   I 4 .   ? 40.50600  -5.36400  32.19800  1.000 39.18868  ?  697 HOH   B O    1 
HETATM 4545 O  O    . HOH   I 4 .   ? 27.74900  2.35100   77.93900  1.000 47.62371  ?  698 HOH   B O    1 
HETATM 4546 O  O    . HOH   I 4 .   ? 28.29200  8.63600   27.69000  1.000 41.07829  ?  699 HOH   B O    1 
HETATM 4547 O  O    . HOH   I 4 .   ? 33.00100  9.37100   69.46600  1.000 35.15795  ?  700 HOH   B O    1 
HETATM 4548 O  O    . HOH   I 4 .   ? 23.81300  12.64000  38.39200  1.000 41.97599  ?  701 HOH   B O    1 
HETATM 4549 O  O    . HOH   I 4 .   ? 39.62200  9.72900   35.34600  1.000 44.79115  ?  702 HOH   B O    1 
HETATM 4550 O  O    . HOH   I 4 .   ? 45.44700  -2.00000  55.88700  1.000 43.61592  ?  703 HOH   B O    1 
HETATM 4551 O  O    . HOH   I 4 .   ? 43.57500  -7.80600  59.20300  1.000 35.72569  ?  704 HOH   B O    1 
HETATM 4552 O  O    . HOH   I 4 .   ? 19.691    -3.025    79.578    1.000 37.34914  ?  705 HOH   B O    1 
HETATM 4553 O  O    . HOH   I 4 .   ? 41.91800  2.70300   69.08500  1.000 43.71556  ?  706 HOH   B O    1 
HETATM 4554 O  O    . HOH   I 4 .   ? 20.84900  2.52500   79.78500  1.000 39.47048  ?  707 HOH   B O    1 
HETATM 4555 O  O    . HOH   I 4 .   ? 45.85200  -2.14600  65.39100  1.000 37.33155  ?  708 HOH   B O    1 
HETATM 4556 O  O    . HOH   I 4 .   ? 43.46100  -2.00500  50.38500  1.000 39.50330  ?  709 HOH   B O    1 
HETATM 4557 O  O    . HOH   I 4 .   ? 51.12400  1.17500   39.80400  1.000 56.30060  ?  710 HOH   B O    1 
HETATM 4558 O  O    . HOH   I 4 .   ? 26.46300  8.14000   72.05300  1.000 38.23666  ?  711 HOH   B O    1 
HETATM 4559 O  O    . HOH   I 4 .   ? 19.76600  -1.00400  31.86100  1.000 39.00522  ?  712 HOH   B O    1 
HETATM 4560 O  O    . HOH   I 4 .   ? 26.77800  22.02600  60.48900  1.000 35.27481  ?  713 HOH   B O    1 
HETATM 4561 O  O    . HOH   I 4 .   ? 46.73000  -1.79800  36.39400  1.000 36.43366  ?  714 HOH   B O    1 
HETATM 4562 O  O    A HOH   I 4 .   ? 21.89200  7.30500   66.17500  0.570 25.96327  ?  715 HOH   B O    1 
HETATM 4563 O  O    B HOH   I 4 .   ? 20.52100  9.02700   65.58300  0.430 26.55598  ?  715 HOH   B O    1 
HETATM 4564 O  O    . HOH   I 4 .   ? 14.36900  -3.70600  45.15100  1.000 47.74754  ?  716 HOH   B O    1 
HETATM 4565 O  O    . HOH   I 4 .   ? 33.29600  -14.26400 64.83200  1.000 58.82192  ?  717 HOH   B O    1 
HETATM 4566 O  O    A HOH   I 4 .   ? 35.34700  -7.96300  78.40100  0.510 30.65151  ?  718 HOH   B O    1 
HETATM 4567 O  O    B HOH   I 4 .   ? 36.28500  -9.92500  78.42400  0.490 31.34538  ?  718 HOH   B O    1 
HETATM 4568 O  O    . HOH   I 4 .   ? 32.27400  18.20000  61.89600  1.000 52.81802  ?  719 HOH   B O    1 
HETATM 4569 O  O    . HOH   I 4 .   ? 29.93200  -10.56400 59.72900  1.000 36.44814  ?  720 HOH   B O    1 
HETATM 4570 O  O    . HOH   I 4 .   ? 14.316    -0.320    73.159    1.000 38.23305  ?  721 HOH   B O    1 
HETATM 4571 O  O    . HOH   I 4 .   ? 31.03100  -2.98100  26.16200  1.000 42.43529  ?  722 HOH   B O    1 
HETATM 4572 O  O    . HOH   I 4 .   ? 29.51000  -18.19800 29.52700  1.000 57.84109  ?  723 HOH   B O    1 
HETATM 4573 O  O    . HOH   I 4 .   ? 44.75900  1.16900   51.21700  1.000 52.53559  ?  724 HOH   B O    1 
HETATM 4574 O  O    . HOH   I 4 .   ? 38.43500  -15.73400 59.04500  1.000 48.42350  ?  725 HOH   B O    1 
HETATM 4575 O  O    . HOH   I 4 .   ? 11.56800  11.20400  57.19700  1.000 40.58784  ?  726 HOH   B O    1 
HETATM 4576 O  O    . HOH   I 4 .   ? 30.36200  0.36000   79.92900  1.000 50.17815  ?  727 HOH   B O    1 
HETATM 4577 O  O    . HOH   I 4 .   ? 21.33800  -5.65800  71.01100  1.000 41.24557  ?  728 HOH   B O    1 
HETATM 4578 O  O    . HOH   I 4 .   ? 32.90200  -8.49100  57.76700  1.000 33.20816  ?  729 HOH   B O    1 
HETATM 4579 O  O    . HOH   I 4 .   ? 32.20500  7.45800   41.01300  1.000 36.95524  ?  730 HOH   B O    1 
HETATM 4580 O  O    A HOH   I 4 .   ? 30.98500  -17.41900 51.35600  0.510 32.98572  ?  731 HOH   B O    1 
HETATM 4581 O  O    B HOH   I 4 .   ? 31.32400  -16.79600 52.76500  0.490 35.63417  ?  731 HOH   B O    1 
HETATM 4582 O  O    . HOH   I 4 .   ? 46.14800  -0.95600  34.26000  1.000 36.06776  ?  732 HOH   B O    1 
HETATM 4583 O  O    . HOH   I 4 .   ? 45.96300  -0.51100  72.58800  1.000 53.01944  ?  733 HOH   B O    1 
HETATM 4584 O  O    A HOH   I 4 .   ? 28.97800  -8.38700  73.00500  0.500 39.65038  ?  734 HOH   B O    1 
HETATM 4585 O  O    B HOH   I 4 .   ? 28.19600  -8.19100  73.93300  0.500 45.20015  ?  734 HOH   B O    1 
HETATM 4586 O  O    . HOH   I 4 .   ? 30.95800  1.13900   19.39300  1.000 56.49032  ?  735 HOH   B O    1 
HETATM 4587 O  O    . HOH   I 4 .   ? 50.92500  1.72500   42.25800  1.000 59.90781  ?  736 HOH   B O    1 
HETATM 4588 O  O    . HOH   I 4 .   ? 25.53900  5.97700   72.17900  1.000 36.98775  ?  737 HOH   B O    1 
HETATM 4589 O  O    . HOH   I 4 .   ? 34.25000  -12.50300 58.61500  1.000 32.97445  ?  738 HOH   B O    1 
HETATM 4590 O  O    . HOH   I 4 .   ? 31.33900  6.57500   43.64000  1.000 38.37973  ?  739 HOH   B O    1 
HETATM 4591 O  O    . HOH   I 4 .   ? 42.96500  -7.00300  66.42800  1.000 39.35267  ?  740 HOH   B O    1 
HETATM 4592 O  O    . HOH   I 4 .   ? 43.42500  0.14200   49.70400  1.000 39.31263  ?  741 HOH   B O    1 
HETATM 4593 O  O    A HOH   I 4 .   ? 23.13200  22.53100  62.20000  0.580 35.59693  ?  742 HOH   B O    1 
HETATM 4594 O  O    B HOH   I 4 .   ? 24.70100  21.09800  60.99800  0.420 22.11892  ?  742 HOH   B O    1 
HETATM 4595 O  O    . HOH   I 4 .   ? 18.94600  13.29000  63.96100  1.000 39.57445  ?  743 HOH   B O    1 
HETATM 4596 O  O    . HOH   I 4 .   ? 18.30200  -12.96300 56.92100  1.000 39.03321  ?  744 HOH   B O    1 
HETATM 4597 O  O    . HOH   I 4 .   ? 30.39900  -10.85000 57.30900  1.000 34.12515  ?  745 HOH   B O    1 
HETATM 4598 O  O    . HOH   I 4 .   ? 47.51800  -8.93300  47.10600  1.000 56.54397  ?  746 HOH   B O    1 
HETATM 4599 O  O    . HOH   I 4 .   ? 13.67900  0.09800   62.56400  1.000 36.00022  ?  747 HOH   B O    1 
HETATM 4600 O  O    . HOH   I 4 .   ? 24.48300  -13.98800 66.89600  1.000 48.74946  ?  748 HOH   B O    1 
HETATM 4601 O  O    . HOH   J 4 .   ? 19.75400  15.93600  43.28000  1.000 44.31343  ?  701 HOH   D O    1 
HETATM 4602 O  O    . HOH   J 4 .   ? 11.68500  10.99400  42.53900  1.000 29.46457  ?  702 HOH   D O    1 
HETATM 4603 O  O    . HOH   J 4 .   ? 13.31000  5.01900   41.59100  1.000 30.86745  ?  703 HOH   D O    1 
# 
