data_9M0S
# 
_entry.id   9M0S 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9M0S         pdb_00009m0s 10.2210/pdb9m0s/pdb 
WWPDB D_1300056962 ?            ?                   
EMDB  EMD-63562    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-04-23 ? 
2 'EM metadata'     1 0 2025-04-23 ? 
3 'Half map'        1 0 2025-04-23 1 
4 'Half map'        1 0 2025-04-23 2 
5 Image             1 0 2025-04-23 ? 
6 'Primary map'     1 0 2025-04-23 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 'Half map'        repository 'Initial release' ? ? 
4 4 'Half map'        repository 'Initial release' ? ? 
5 5 Image             repository 'Initial release' ? ? 
6 6 'Primary map'     repository 'Initial release' ? ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9M0S 
_pdbx_database_status.recvd_initial_deposition_date   2025-02-25 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Acetyl-CoA-bound SLC33A1 in a cytoplasm-facing conformation' 
_pdbx_database_related.db_id          EMD-63562 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              zzhang01@pku.edu.cn 
_pdbx_contact_author.name_first         Zhe 
_pdbx_contact_author.name_last          Zhang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-4932-4343 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zhou, D.'  1 0000-0002-4932-0000 
'Zhang, Z.' 2 0000-0002-4932-4343 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Cell Discov' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2056-5968 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            11 
_citation.language                  ? 
_citation.page_first                36 
_citation.page_last                 36 
_citation.title                     'Mechanistic insights into the acetyl-CoA recognition by SLC33A1.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41421-025-00793-1 
_citation.pdbx_database_id_PubMed   40204708 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zhou, D.'  1 ?                   
primary 'Chen, N.'  2 ?                   
primary 'Huang, S.' 3 ?                   
primary 'Song, C.'  4 0000-0001-9730-3216 
primary 'Zhang, Z.' 5 0000-0002-4932-4343 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Acetyl-coenzyme A transporter 1' 62131.855 1 ? ? ? ? 
2 non-polymer syn 'ACETYL COENZYME *A'              809.571   1 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'AT-1,Acetyl-CoA transporter 1,Solute carrier family 33 member 1' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGDFLKAPQSFRAELSSILLLLF
LYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLST
QVDRLLGNTDDRTPDVIALTVAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADF
CNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVKEETQGITDTYKLLFAIIKMPAVLTFCLLILTA
KIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILPLIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKV
EHQGGFPIYYYIVVLLSYALHQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECV
GASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFLGPKFKKLQDEGSSSWKCKRNNLEGGSLEVLFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGDFLKAPQSFRAELSSILLLLF
LYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLST
QVDRLLGNTDDRTPDVIALTVAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADF
CNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVKEETQGITDTYKLLFAIIKMPAVLTFCLLILTA
KIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILPLIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKV
EHQGGFPIYYYIVVLLSYALHQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECV
GASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFLGPKFKKLQDEGSSSWKCKRNNLEGGSLEVLFQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        'ACETYL COENZYME *A' 
_pdbx_entity_nonpoly.comp_id     ACO 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   SER n 
1 3   PRO n 
1 4   THR n 
1 5   ILE n 
1 6   SER n 
1 7   HIS n 
1 8   LYS n 
1 9   ASP n 
1 10  SER n 
1 11  SER n 
1 12  ARG n 
1 13  GLN n 
1 14  ARG n 
1 15  ARG n 
1 16  PRO n 
1 17  GLY n 
1 18  ASN n 
1 19  PHE n 
1 20  SER n 
1 21  HIS n 
1 22  SER n 
1 23  LEU n 
1 24  ASP n 
1 25  MET n 
1 26  LYS n 
1 27  SER n 
1 28  GLY n 
1 29  PRO n 
1 30  LEU n 
1 31  PRO n 
1 32  PRO n 
1 33  GLY n 
1 34  GLY n 
1 35  TRP n 
1 36  ASP n 
1 37  ASP n 
1 38  SER n 
1 39  HIS n 
1 40  LEU n 
1 41  ASP n 
1 42  SER n 
1 43  ALA n 
1 44  GLY n 
1 45  ARG n 
1 46  GLU n 
1 47  GLY n 
1 48  ASP n 
1 49  ARG n 
1 50  GLU n 
1 51  ALA n 
1 52  LEU n 
1 53  LEU n 
1 54  GLY n 
1 55  ASP n 
1 56  THR n 
1 57  GLY n 
1 58  THR n 
1 59  GLY n 
1 60  ASP n 
1 61  PHE n 
1 62  LEU n 
1 63  LYS n 
1 64  ALA n 
1 65  PRO n 
1 66  GLN n 
1 67  SER n 
1 68  PHE n 
1 69  ARG n 
1 70  ALA n 
1 71  GLU n 
1 72  LEU n 
1 73  SER n 
1 74  SER n 
1 75  ILE n 
1 76  LEU n 
1 77  LEU n 
1 78  LEU n 
1 79  LEU n 
1 80  PHE n 
1 81  LEU n 
1 82  TYR n 
1 83  VAL n 
1 84  LEU n 
1 85  GLN n 
1 86  GLY n 
1 87  ILE n 
1 88  PRO n 
1 89  LEU n 
1 90  GLY n 
1 91  LEU n 
1 92  ALA n 
1 93  GLY n 
1 94  SER n 
1 95  ILE n 
1 96  PRO n 
1 97  LEU n 
1 98  ILE n 
1 99  LEU n 
1 100 GLN n 
1 101 SER n 
1 102 LYS n 
1 103 ASN n 
1 104 VAL n 
1 105 SER n 
1 106 TYR n 
1 107 THR n 
1 108 ASP n 
1 109 GLN n 
1 110 ALA n 
1 111 PHE n 
1 112 PHE n 
1 113 SER n 
1 114 PHE n 
1 115 VAL n 
1 116 PHE n 
1 117 TRP n 
1 118 PRO n 
1 119 PHE n 
1 120 SER n 
1 121 LEU n 
1 122 LYS n 
1 123 LEU n 
1 124 LEU n 
1 125 TRP n 
1 126 ALA n 
1 127 PRO n 
1 128 LEU n 
1 129 VAL n 
1 130 ASP n 
1 131 ALA n 
1 132 VAL n 
1 133 TYR n 
1 134 VAL n 
1 135 LYS n 
1 136 ASN n 
1 137 PHE n 
1 138 GLY n 
1 139 ARG n 
1 140 ARG n 
1 141 LYS n 
1 142 SER n 
1 143 TRP n 
1 144 LEU n 
1 145 VAL n 
1 146 PRO n 
1 147 THR n 
1 148 GLN n 
1 149 TYR n 
1 150 ILE n 
1 151 LEU n 
1 152 GLY n 
1 153 LEU n 
1 154 PHE n 
1 155 MET n 
1 156 ILE n 
1 157 TYR n 
1 158 LEU n 
1 159 SER n 
1 160 THR n 
1 161 GLN n 
1 162 VAL n 
1 163 ASP n 
1 164 ARG n 
1 165 LEU n 
1 166 LEU n 
1 167 GLY n 
1 168 ASN n 
1 169 THR n 
1 170 ASP n 
1 171 ASP n 
1 172 ARG n 
1 173 THR n 
1 174 PRO n 
1 175 ASP n 
1 176 VAL n 
1 177 ILE n 
1 178 ALA n 
1 179 LEU n 
1 180 THR n 
1 181 VAL n 
1 182 ALA n 
1 183 PHE n 
1 184 PHE n 
1 185 LEU n 
1 186 PHE n 
1 187 GLU n 
1 188 PHE n 
1 189 LEU n 
1 190 ALA n 
1 191 ALA n 
1 192 THR n 
1 193 GLN n 
1 194 ASP n 
1 195 ILE n 
1 196 ALA n 
1 197 VAL n 
1 198 ASP n 
1 199 GLY n 
1 200 TRP n 
1 201 ALA n 
1 202 LEU n 
1 203 THR n 
1 204 MET n 
1 205 LEU n 
1 206 SER n 
1 207 ARG n 
1 208 GLU n 
1 209 ASN n 
1 210 VAL n 
1 211 GLY n 
1 212 TYR n 
1 213 ALA n 
1 214 SER n 
1 215 THR n 
1 216 CYS n 
1 217 ASN n 
1 218 SER n 
1 219 VAL n 
1 220 GLY n 
1 221 GLN n 
1 222 THR n 
1 223 ALA n 
1 224 GLY n 
1 225 TYR n 
1 226 PHE n 
1 227 LEU n 
1 228 GLY n 
1 229 ASN n 
1 230 VAL n 
1 231 LEU n 
1 232 PHE n 
1 233 LEU n 
1 234 ALA n 
1 235 LEU n 
1 236 GLU n 
1 237 SER n 
1 238 ALA n 
1 239 ASP n 
1 240 PHE n 
1 241 CYS n 
1 242 ASN n 
1 243 LYS n 
1 244 TYR n 
1 245 LEU n 
1 246 ARG n 
1 247 PHE n 
1 248 GLN n 
1 249 PRO n 
1 250 GLN n 
1 251 PRO n 
1 252 ARG n 
1 253 GLY n 
1 254 ILE n 
1 255 VAL n 
1 256 THR n 
1 257 LEU n 
1 258 SER n 
1 259 ASP n 
1 260 PHE n 
1 261 LEU n 
1 262 PHE n 
1 263 PHE n 
1 264 TRP n 
1 265 GLY n 
1 266 THR n 
1 267 VAL n 
1 268 PHE n 
1 269 LEU n 
1 270 ILE n 
1 271 THR n 
1 272 THR n 
1 273 THR n 
1 274 LEU n 
1 275 VAL n 
1 276 ALA n 
1 277 LEU n 
1 278 LEU n 
1 279 LYS n 
1 280 LYS n 
1 281 GLU n 
1 282 ASN n 
1 283 GLU n 
1 284 VAL n 
1 285 SER n 
1 286 VAL n 
1 287 VAL n 
1 288 LYS n 
1 289 GLU n 
1 290 GLU n 
1 291 THR n 
1 292 GLN n 
1 293 GLY n 
1 294 ILE n 
1 295 THR n 
1 296 ASP n 
1 297 THR n 
1 298 TYR n 
1 299 LYS n 
1 300 LEU n 
1 301 LEU n 
1 302 PHE n 
1 303 ALA n 
1 304 ILE n 
1 305 ILE n 
1 306 LYS n 
1 307 MET n 
1 308 PRO n 
1 309 ALA n 
1 310 VAL n 
1 311 LEU n 
1 312 THR n 
1 313 PHE n 
1 314 CYS n 
1 315 LEU n 
1 316 LEU n 
1 317 ILE n 
1 318 LEU n 
1 319 THR n 
1 320 ALA n 
1 321 LYS n 
1 322 ILE n 
1 323 GLY n 
1 324 PHE n 
1 325 SER n 
1 326 ALA n 
1 327 ALA n 
1 328 ASP n 
1 329 ALA n 
1 330 VAL n 
1 331 THR n 
1 332 GLY n 
1 333 LEU n 
1 334 LYS n 
1 335 LEU n 
1 336 VAL n 
1 337 GLU n 
1 338 GLU n 
1 339 GLY n 
1 340 VAL n 
1 341 PRO n 
1 342 LYS n 
1 343 GLU n 
1 344 HIS n 
1 345 LEU n 
1 346 ALA n 
1 347 LEU n 
1 348 LEU n 
1 349 ALA n 
1 350 VAL n 
1 351 PRO n 
1 352 MET n 
1 353 VAL n 
1 354 PRO n 
1 355 LEU n 
1 356 GLN n 
1 357 ILE n 
1 358 ILE n 
1 359 LEU n 
1 360 PRO n 
1 361 LEU n 
1 362 ILE n 
1 363 ILE n 
1 364 SER n 
1 365 LYS n 
1 366 TYR n 
1 367 THR n 
1 368 ALA n 
1 369 GLY n 
1 370 PRO n 
1 371 GLN n 
1 372 PRO n 
1 373 LEU n 
1 374 ASN n 
1 375 THR n 
1 376 PHE n 
1 377 TYR n 
1 378 LYS n 
1 379 ALA n 
1 380 MET n 
1 381 PRO n 
1 382 TYR n 
1 383 ARG n 
1 384 LEU n 
1 385 LEU n 
1 386 LEU n 
1 387 GLY n 
1 388 LEU n 
1 389 GLU n 
1 390 TYR n 
1 391 ALA n 
1 392 LEU n 
1 393 LEU n 
1 394 VAL n 
1 395 TRP n 
1 396 TRP n 
1 397 THR n 
1 398 PRO n 
1 399 LYS n 
1 400 VAL n 
1 401 GLU n 
1 402 HIS n 
1 403 GLN n 
1 404 GLY n 
1 405 GLY n 
1 406 PHE n 
1 407 PRO n 
1 408 ILE n 
1 409 TYR n 
1 410 TYR n 
1 411 TYR n 
1 412 ILE n 
1 413 VAL n 
1 414 VAL n 
1 415 LEU n 
1 416 LEU n 
1 417 SER n 
1 418 TYR n 
1 419 ALA n 
1 420 LEU n 
1 421 HIS n 
1 422 GLN n 
1 423 VAL n 
1 424 THR n 
1 425 VAL n 
1 426 TYR n 
1 427 SER n 
1 428 MET n 
1 429 TYR n 
1 430 VAL n 
1 431 SER n 
1 432 ILE n 
1 433 MET n 
1 434 ALA n 
1 435 PHE n 
1 436 ASN n 
1 437 ALA n 
1 438 LYS n 
1 439 VAL n 
1 440 SER n 
1 441 ASP n 
1 442 PRO n 
1 443 LEU n 
1 444 ILE n 
1 445 GLY n 
1 446 GLY n 
1 447 THR n 
1 448 TYR n 
1 449 MET n 
1 450 THR n 
1 451 LEU n 
1 452 LEU n 
1 453 ASN n 
1 454 THR n 
1 455 VAL n 
1 456 SER n 
1 457 ASN n 
1 458 LEU n 
1 459 GLY n 
1 460 GLY n 
1 461 ASN n 
1 462 TRP n 
1 463 PRO n 
1 464 SER n 
1 465 THR n 
1 466 VAL n 
1 467 ALA n 
1 468 LEU n 
1 469 TRP n 
1 470 LEU n 
1 471 VAL n 
1 472 ASP n 
1 473 PRO n 
1 474 LEU n 
1 475 THR n 
1 476 VAL n 
1 477 LYS n 
1 478 GLU n 
1 479 CYS n 
1 480 VAL n 
1 481 GLY n 
1 482 ALA n 
1 483 SER n 
1 484 ASN n 
1 485 GLN n 
1 486 ASN n 
1 487 CYS n 
1 488 ARG n 
1 489 THR n 
1 490 PRO n 
1 491 ASP n 
1 492 ALA n 
1 493 VAL n 
1 494 GLU n 
1 495 LEU n 
1 496 CYS n 
1 497 LYS n 
1 498 LYS n 
1 499 LEU n 
1 500 GLY n 
1 501 GLY n 
1 502 SER n 
1 503 CYS n 
1 504 VAL n 
1 505 THR n 
1 506 ALA n 
1 507 LEU n 
1 508 ASP n 
1 509 GLY n 
1 510 TYR n 
1 511 TYR n 
1 512 VAL n 
1 513 GLU n 
1 514 SER n 
1 515 ILE n 
1 516 ILE n 
1 517 CYS n 
1 518 VAL n 
1 519 PHE n 
1 520 ILE n 
1 521 GLY n 
1 522 PHE n 
1 523 GLY n 
1 524 TRP n 
1 525 TRP n 
1 526 PHE n 
1 527 PHE n 
1 528 LEU n 
1 529 GLY n 
1 530 PRO n 
1 531 LYS n 
1 532 PHE n 
1 533 LYS n 
1 534 LYS n 
1 535 LEU n 
1 536 GLN n 
1 537 ASP n 
1 538 GLU n 
1 539 GLY n 
1 540 SER n 
1 541 SER n 
1 542 SER n 
1 543 TRP n 
1 544 LYS n 
1 545 CYS n 
1 546 LYS n 
1 547 ARG n 
1 548 ASN n 
1 549 ASN n 
1 550 LEU n 
1 551 GLU n 
1 552 GLY n 
1 553 GLY n 
1 554 SER n 
1 555 LEU n 
1 556 GLU n 
1 557 VAL n 
1 558 LEU n 
1 559 PHE n 
1 560 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   560 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'SLC33A1, ACATN, AT1' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ACO non-polymer         . 'ACETYL COENZYME *A' ? 'C23 H38 N7 O17 P3 S' 809.571 
ALA 'L-peptide linking' y ALANINE              ? 'C3 H7 N O2'          89.093  
ARG 'L-peptide linking' y ARGININE             ? 'C6 H15 N4 O2 1'      175.209 
ASN 'L-peptide linking' y ASPARAGINE           ? 'C4 H8 N2 O3'         132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'      ? 'C4 H7 N O4'          133.103 
CYS 'L-peptide linking' y CYSTEINE             ? 'C3 H7 N O2 S'        121.158 
GLN 'L-peptide linking' y GLUTAMINE            ? 'C5 H10 N2 O3'        146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'      ? 'C5 H9 N O4'          147.129 
GLY 'peptide linking'   y GLYCINE              ? 'C2 H5 N O2'          75.067  
HIS 'L-peptide linking' y HISTIDINE            ? 'C6 H10 N3 O2 1'      156.162 
ILE 'L-peptide linking' y ISOLEUCINE           ? 'C6 H13 N O2'         131.173 
LEU 'L-peptide linking' y LEUCINE              ? 'C6 H13 N O2'         131.173 
LYS 'L-peptide linking' y LYSINE               ? 'C6 H15 N2 O2 1'      147.195 
MET 'L-peptide linking' y METHIONINE           ? 'C5 H11 N O2 S'       149.211 
PHE 'L-peptide linking' y PHENYLALANINE        ? 'C9 H11 N O2'         165.189 
PRO 'L-peptide linking' y PROLINE              ? 'C5 H9 N O2'          115.130 
SER 'L-peptide linking' y SERINE               ? 'C3 H7 N O3'          105.093 
THR 'L-peptide linking' y THREONINE            ? 'C4 H9 N O3'          119.119 
TRP 'L-peptide linking' y TRYPTOPHAN           ? 'C11 H12 N2 O2'       204.225 
TYR 'L-peptide linking' y TYROSINE             ? 'C9 H11 N O3'         181.189 
VAL 'L-peptide linking' y VALINE               ? 'C5 H11 N O2'         117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   SER 2   2   ?   ?   ?   A . n 
A 1 3   PRO 3   3   ?   ?   ?   A . n 
A 1 4   THR 4   4   ?   ?   ?   A . n 
A 1 5   ILE 5   5   ?   ?   ?   A . n 
A 1 6   SER 6   6   ?   ?   ?   A . n 
A 1 7   HIS 7   7   ?   ?   ?   A . n 
A 1 8   LYS 8   8   ?   ?   ?   A . n 
A 1 9   ASP 9   9   ?   ?   ?   A . n 
A 1 10  SER 10  10  ?   ?   ?   A . n 
A 1 11  SER 11  11  ?   ?   ?   A . n 
A 1 12  ARG 12  12  ?   ?   ?   A . n 
A 1 13  GLN 13  13  ?   ?   ?   A . n 
A 1 14  ARG 14  14  ?   ?   ?   A . n 
A 1 15  ARG 15  15  ?   ?   ?   A . n 
A 1 16  PRO 16  16  ?   ?   ?   A . n 
A 1 17  GLY 17  17  ?   ?   ?   A . n 
A 1 18  ASN 18  18  ?   ?   ?   A . n 
A 1 19  PHE 19  19  ?   ?   ?   A . n 
A 1 20  SER 20  20  ?   ?   ?   A . n 
A 1 21  HIS 21  21  ?   ?   ?   A . n 
A 1 22  SER 22  22  ?   ?   ?   A . n 
A 1 23  LEU 23  23  ?   ?   ?   A . n 
A 1 24  ASP 24  24  ?   ?   ?   A . n 
A 1 25  MET 25  25  ?   ?   ?   A . n 
A 1 26  LYS 26  26  ?   ?   ?   A . n 
A 1 27  SER 27  27  ?   ?   ?   A . n 
A 1 28  GLY 28  28  ?   ?   ?   A . n 
A 1 29  PRO 29  29  ?   ?   ?   A . n 
A 1 30  LEU 30  30  ?   ?   ?   A . n 
A 1 31  PRO 31  31  ?   ?   ?   A . n 
A 1 32  PRO 32  32  ?   ?   ?   A . n 
A 1 33  GLY 33  33  ?   ?   ?   A . n 
A 1 34  GLY 34  34  ?   ?   ?   A . n 
A 1 35  TRP 35  35  ?   ?   ?   A . n 
A 1 36  ASP 36  36  ?   ?   ?   A . n 
A 1 37  ASP 37  37  ?   ?   ?   A . n 
A 1 38  SER 38  38  ?   ?   ?   A . n 
A 1 39  HIS 39  39  ?   ?   ?   A . n 
A 1 40  LEU 40  40  ?   ?   ?   A . n 
A 1 41  ASP 41  41  ?   ?   ?   A . n 
A 1 42  SER 42  42  ?   ?   ?   A . n 
A 1 43  ALA 43  43  ?   ?   ?   A . n 
A 1 44  GLY 44  44  ?   ?   ?   A . n 
A 1 45  ARG 45  45  ?   ?   ?   A . n 
A 1 46  GLU 46  46  ?   ?   ?   A . n 
A 1 47  GLY 47  47  ?   ?   ?   A . n 
A 1 48  ASP 48  48  ?   ?   ?   A . n 
A 1 49  ARG 49  49  ?   ?   ?   A . n 
A 1 50  GLU 50  50  ?   ?   ?   A . n 
A 1 51  ALA 51  51  ?   ?   ?   A . n 
A 1 52  LEU 52  52  ?   ?   ?   A . n 
A 1 53  LEU 53  53  ?   ?   ?   A . n 
A 1 54  GLY 54  54  ?   ?   ?   A . n 
A 1 55  ASP 55  55  ?   ?   ?   A . n 
A 1 56  THR 56  56  ?   ?   ?   A . n 
A 1 57  GLY 57  57  ?   ?   ?   A . n 
A 1 58  THR 58  58  ?   ?   ?   A . n 
A 1 59  GLY 59  59  ?   ?   ?   A . n 
A 1 60  ASP 60  60  ?   ?   ?   A . n 
A 1 61  PHE 61  61  ?   ?   ?   A . n 
A 1 62  LEU 62  62  ?   ?   ?   A . n 
A 1 63  LYS 63  63  ?   ?   ?   A . n 
A 1 64  ALA 64  64  ?   ?   ?   A . n 
A 1 65  PRO 65  65  ?   ?   ?   A . n 
A 1 66  GLN 66  66  ?   ?   ?   A . n 
A 1 67  SER 67  67  ?   ?   ?   A . n 
A 1 68  PHE 68  68  ?   ?   ?   A . n 
A 1 69  ARG 69  69  ?   ?   ?   A . n 
A 1 70  ALA 70  70  ?   ?   ?   A . n 
A 1 71  GLU 71  71  71  GLU GLU A . n 
A 1 72  LEU 72  72  72  LEU LEU A . n 
A 1 73  SER 73  73  73  SER SER A . n 
A 1 74  SER 74  74  74  SER SER A . n 
A 1 75  ILE 75  75  75  ILE ILE A . n 
A 1 76  LEU 76  76  76  LEU LEU A . n 
A 1 77  LEU 77  77  77  LEU LEU A . n 
A 1 78  LEU 78  78  78  LEU LEU A . n 
A 1 79  LEU 79  79  79  LEU LEU A . n 
A 1 80  PHE 80  80  80  PHE PHE A . n 
A 1 81  LEU 81  81  81  LEU LEU A . n 
A 1 82  TYR 82  82  82  TYR TYR A . n 
A 1 83  VAL 83  83  83  VAL VAL A . n 
A 1 84  LEU 84  84  84  LEU LEU A . n 
A 1 85  GLN 85  85  85  GLN GLN A . n 
A 1 86  GLY 86  86  86  GLY GLY A . n 
A 1 87  ILE 87  87  87  ILE ILE A . n 
A 1 88  PRO 88  88  88  PRO PRO A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  GLY 90  90  90  GLY GLY A . n 
A 1 91  LEU 91  91  91  LEU LEU A . n 
A 1 92  ALA 92  92  92  ALA ALA A . n 
A 1 93  GLY 93  93  93  GLY GLY A . n 
A 1 94  SER 94  94  94  SER SER A . n 
A 1 95  ILE 95  95  95  ILE ILE A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LEU 97  97  97  LEU LEU A . n 
A 1 98  ILE 98  98  98  ILE ILE A . n 
A 1 99  LEU 99  99  99  LEU LEU A . n 
A 1 100 GLN 100 100 100 GLN GLN A . n 
A 1 101 SER 101 101 101 SER SER A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 ASN 103 103 103 ASN ASN A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 SER 105 105 105 SER SER A . n 
A 1 106 TYR 106 106 106 TYR TYR A . n 
A 1 107 THR 107 107 107 THR THR A . n 
A 1 108 ASP 108 108 108 ASP ASP A . n 
A 1 109 GLN 109 109 109 GLN GLN A . n 
A 1 110 ALA 110 110 110 ALA ALA A . n 
A 1 111 PHE 111 111 111 PHE PHE A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 PHE 114 114 114 PHE PHE A . n 
A 1 115 VAL 115 115 115 VAL VAL A . n 
A 1 116 PHE 116 116 116 PHE PHE A . n 
A 1 117 TRP 117 117 117 TRP TRP A . n 
A 1 118 PRO 118 118 118 PRO PRO A . n 
A 1 119 PHE 119 119 119 PHE PHE A . n 
A 1 120 SER 120 120 120 SER SER A . n 
A 1 121 LEU 121 121 121 LEU LEU A . n 
A 1 122 LYS 122 122 122 LYS LYS A . n 
A 1 123 LEU 123 123 123 LEU LEU A . n 
A 1 124 LEU 124 124 124 LEU LEU A . n 
A 1 125 TRP 125 125 125 TRP TRP A . n 
A 1 126 ALA 126 126 126 ALA ALA A . n 
A 1 127 PRO 127 127 127 PRO PRO A . n 
A 1 128 LEU 128 128 128 LEU LEU A . n 
A 1 129 VAL 129 129 129 VAL VAL A . n 
A 1 130 ASP 130 130 130 ASP ASP A . n 
A 1 131 ALA 131 131 131 ALA ALA A . n 
A 1 132 VAL 132 132 132 VAL VAL A . n 
A 1 133 TYR 133 133 133 TYR TYR A . n 
A 1 134 VAL 134 134 134 VAL VAL A . n 
A 1 135 LYS 135 135 135 LYS LYS A . n 
A 1 136 ASN 136 136 136 ASN ASN A . n 
A 1 137 PHE 137 137 137 PHE PHE A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 ARG 139 139 139 ARG ARG A . n 
A 1 140 ARG 140 140 140 ARG ARG A . n 
A 1 141 LYS 141 141 141 LYS LYS A . n 
A 1 142 SER 142 142 142 SER SER A . n 
A 1 143 TRP 143 143 143 TRP TRP A . n 
A 1 144 LEU 144 144 144 LEU LEU A . n 
A 1 145 VAL 145 145 145 VAL VAL A . n 
A 1 146 PRO 146 146 146 PRO PRO A . n 
A 1 147 THR 147 147 147 THR THR A . n 
A 1 148 GLN 148 148 148 GLN GLN A . n 
A 1 149 TYR 149 149 149 TYR TYR A . n 
A 1 150 ILE 150 150 150 ILE ILE A . n 
A 1 151 LEU 151 151 151 LEU LEU A . n 
A 1 152 GLY 152 152 152 GLY GLY A . n 
A 1 153 LEU 153 153 153 LEU LEU A . n 
A 1 154 PHE 154 154 154 PHE PHE A . n 
A 1 155 MET 155 155 155 MET MET A . n 
A 1 156 ILE 156 156 156 ILE ILE A . n 
A 1 157 TYR 157 157 157 TYR TYR A . n 
A 1 158 LEU 158 158 158 LEU LEU A . n 
A 1 159 SER 159 159 159 SER SER A . n 
A 1 160 THR 160 160 160 THR THR A . n 
A 1 161 GLN 161 161 161 GLN GLN A . n 
A 1 162 VAL 162 162 162 VAL VAL A . n 
A 1 163 ASP 163 163 163 ASP ASP A . n 
A 1 164 ARG 164 164 164 ARG ARG A . n 
A 1 165 LEU 165 165 165 LEU LEU A . n 
A 1 166 LEU 166 166 166 LEU LEU A . n 
A 1 167 GLY 167 167 167 GLY GLY A . n 
A 1 168 ASN 168 168 168 ASN ASN A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 ASP 170 170 170 ASP ASP A . n 
A 1 171 ASP 171 171 171 ASP ASP A . n 
A 1 172 ARG 172 172 172 ARG ARG A . n 
A 1 173 THR 173 173 173 THR THR A . n 
A 1 174 PRO 174 174 174 PRO PRO A . n 
A 1 175 ASP 175 175 175 ASP ASP A . n 
A 1 176 VAL 176 176 176 VAL VAL A . n 
A 1 177 ILE 177 177 177 ILE ILE A . n 
A 1 178 ALA 178 178 178 ALA ALA A . n 
A 1 179 LEU 179 179 179 LEU LEU A . n 
A 1 180 THR 180 180 180 THR THR A . n 
A 1 181 VAL 181 181 181 VAL VAL A . n 
A 1 182 ALA 182 182 182 ALA ALA A . n 
A 1 183 PHE 183 183 183 PHE PHE A . n 
A 1 184 PHE 184 184 184 PHE PHE A . n 
A 1 185 LEU 185 185 185 LEU LEU A . n 
A 1 186 PHE 186 186 186 PHE PHE A . n 
A 1 187 GLU 187 187 187 GLU GLU A . n 
A 1 188 PHE 188 188 188 PHE PHE A . n 
A 1 189 LEU 189 189 189 LEU LEU A . n 
A 1 190 ALA 190 190 190 ALA ALA A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 THR 192 192 192 THR THR A . n 
A 1 193 GLN 193 193 193 GLN GLN A . n 
A 1 194 ASP 194 194 194 ASP ASP A . n 
A 1 195 ILE 195 195 195 ILE ILE A . n 
A 1 196 ALA 196 196 196 ALA ALA A . n 
A 1 197 VAL 197 197 197 VAL VAL A . n 
A 1 198 ASP 198 198 198 ASP ASP A . n 
A 1 199 GLY 199 199 199 GLY GLY A . n 
A 1 200 TRP 200 200 200 TRP TRP A . n 
A 1 201 ALA 201 201 201 ALA ALA A . n 
A 1 202 LEU 202 202 202 LEU LEU A . n 
A 1 203 THR 203 203 203 THR THR A . n 
A 1 204 MET 204 204 204 MET MET A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 SER 206 206 206 SER SER A . n 
A 1 207 ARG 207 207 207 ARG ARG A . n 
A 1 208 GLU 208 208 208 GLU GLU A . n 
A 1 209 ASN 209 209 209 ASN ASN A . n 
A 1 210 VAL 210 210 210 VAL VAL A . n 
A 1 211 GLY 211 211 211 GLY GLY A . n 
A 1 212 TYR 212 212 212 TYR TYR A . n 
A 1 213 ALA 213 213 213 ALA ALA A . n 
A 1 214 SER 214 214 214 SER SER A . n 
A 1 215 THR 215 215 215 THR THR A . n 
A 1 216 CYS 216 216 216 CYS CYS A . n 
A 1 217 ASN 217 217 217 ASN ASN A . n 
A 1 218 SER 218 218 218 SER SER A . n 
A 1 219 VAL 219 219 219 VAL VAL A . n 
A 1 220 GLY 220 220 220 GLY GLY A . n 
A 1 221 GLN 221 221 221 GLN GLN A . n 
A 1 222 THR 222 222 222 THR THR A . n 
A 1 223 ALA 223 223 223 ALA ALA A . n 
A 1 224 GLY 224 224 224 GLY GLY A . n 
A 1 225 TYR 225 225 225 TYR TYR A . n 
A 1 226 PHE 226 226 226 PHE PHE A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 GLY 228 228 228 GLY GLY A . n 
A 1 229 ASN 229 229 229 ASN ASN A . n 
A 1 230 VAL 230 230 230 VAL VAL A . n 
A 1 231 LEU 231 231 231 LEU LEU A . n 
A 1 232 PHE 232 232 232 PHE PHE A . n 
A 1 233 LEU 233 233 233 LEU LEU A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 LEU 235 235 235 LEU LEU A . n 
A 1 236 GLU 236 236 236 GLU GLU A . n 
A 1 237 SER 237 237 237 SER SER A . n 
A 1 238 ALA 238 238 238 ALA ALA A . n 
A 1 239 ASP 239 239 239 ASP ASP A . n 
A 1 240 PHE 240 240 240 PHE PHE A . n 
A 1 241 CYS 241 241 241 CYS CYS A . n 
A 1 242 ASN 242 242 242 ASN ASN A . n 
A 1 243 LYS 243 243 243 LYS LYS A . n 
A 1 244 TYR 244 244 244 TYR TYR A . n 
A 1 245 LEU 245 245 245 LEU LEU A . n 
A 1 246 ARG 246 246 246 ARG ARG A . n 
A 1 247 PHE 247 247 247 PHE PHE A . n 
A 1 248 GLN 248 248 248 GLN GLN A . n 
A 1 249 PRO 249 249 249 PRO PRO A . n 
A 1 250 GLN 250 250 250 GLN GLN A . n 
A 1 251 PRO 251 251 251 PRO PRO A . n 
A 1 252 ARG 252 252 252 ARG ARG A . n 
A 1 253 GLY 253 253 253 GLY GLY A . n 
A 1 254 ILE 254 254 254 ILE ILE A . n 
A 1 255 VAL 255 255 255 VAL VAL A . n 
A 1 256 THR 256 256 256 THR THR A . n 
A 1 257 LEU 257 257 257 LEU LEU A . n 
A 1 258 SER 258 258 258 SER SER A . n 
A 1 259 ASP 259 259 259 ASP ASP A . n 
A 1 260 PHE 260 260 260 PHE PHE A . n 
A 1 261 LEU 261 261 261 LEU LEU A . n 
A 1 262 PHE 262 262 262 PHE PHE A . n 
A 1 263 PHE 263 263 263 PHE PHE A . n 
A 1 264 TRP 264 264 264 TRP TRP A . n 
A 1 265 GLY 265 265 265 GLY GLY A . n 
A 1 266 THR 266 266 266 THR THR A . n 
A 1 267 VAL 267 267 267 VAL VAL A . n 
A 1 268 PHE 268 268 268 PHE PHE A . n 
A 1 269 LEU 269 269 269 LEU LEU A . n 
A 1 270 ILE 270 270 270 ILE ILE A . n 
A 1 271 THR 271 271 271 THR THR A . n 
A 1 272 THR 272 272 272 THR THR A . n 
A 1 273 THR 273 273 273 THR THR A . n 
A 1 274 LEU 274 274 274 LEU LEU A . n 
A 1 275 VAL 275 275 275 VAL VAL A . n 
A 1 276 ALA 276 276 276 ALA ALA A . n 
A 1 277 LEU 277 277 277 LEU LEU A . n 
A 1 278 LEU 278 278 278 LEU LEU A . n 
A 1 279 LYS 279 279 ?   ?   ?   A . n 
A 1 280 LYS 280 280 ?   ?   ?   A . n 
A 1 281 GLU 281 281 ?   ?   ?   A . n 
A 1 282 ASN 282 282 ?   ?   ?   A . n 
A 1 283 GLU 283 283 ?   ?   ?   A . n 
A 1 284 VAL 284 284 ?   ?   ?   A . n 
A 1 285 SER 285 285 ?   ?   ?   A . n 
A 1 286 VAL 286 286 ?   ?   ?   A . n 
A 1 287 VAL 287 287 ?   ?   ?   A . n 
A 1 288 LYS 288 288 ?   ?   ?   A . n 
A 1 289 GLU 289 289 ?   ?   ?   A . n 
A 1 290 GLU 290 290 ?   ?   ?   A . n 
A 1 291 THR 291 291 ?   ?   ?   A . n 
A 1 292 GLN 292 292 ?   ?   ?   A . n 
A 1 293 GLY 293 293 ?   ?   ?   A . n 
A 1 294 ILE 294 294 294 ILE ILE A . n 
A 1 295 THR 295 295 295 THR THR A . n 
A 1 296 ASP 296 296 296 ASP ASP A . n 
A 1 297 THR 297 297 297 THR THR A . n 
A 1 298 TYR 298 298 298 TYR TYR A . n 
A 1 299 LYS 299 299 299 LYS LYS A . n 
A 1 300 LEU 300 300 300 LEU LEU A . n 
A 1 301 LEU 301 301 301 LEU LEU A . n 
A 1 302 PHE 302 302 302 PHE PHE A . n 
A 1 303 ALA 303 303 303 ALA ALA A . n 
A 1 304 ILE 304 304 304 ILE ILE A . n 
A 1 305 ILE 305 305 305 ILE ILE A . n 
A 1 306 LYS 306 306 306 LYS LYS A . n 
A 1 307 MET 307 307 307 MET MET A . n 
A 1 308 PRO 308 308 308 PRO PRO A . n 
A 1 309 ALA 309 309 309 ALA ALA A . n 
A 1 310 VAL 310 310 310 VAL VAL A . n 
A 1 311 LEU 311 311 311 LEU LEU A . n 
A 1 312 THR 312 312 312 THR THR A . n 
A 1 313 PHE 313 313 313 PHE PHE A . n 
A 1 314 CYS 314 314 314 CYS CYS A . n 
A 1 315 LEU 315 315 315 LEU LEU A . n 
A 1 316 LEU 316 316 316 LEU LEU A . n 
A 1 317 ILE 317 317 317 ILE ILE A . n 
A 1 318 LEU 318 318 318 LEU LEU A . n 
A 1 319 THR 319 319 319 THR THR A . n 
A 1 320 ALA 320 320 320 ALA ALA A . n 
A 1 321 LYS 321 321 321 LYS LYS A . n 
A 1 322 ILE 322 322 322 ILE ILE A . n 
A 1 323 GLY 323 323 323 GLY GLY A . n 
A 1 324 PHE 324 324 324 PHE PHE A . n 
A 1 325 SER 325 325 325 SER SER A . n 
A 1 326 ALA 326 326 326 ALA ALA A . n 
A 1 327 ALA 327 327 327 ALA ALA A . n 
A 1 328 ASP 328 328 328 ASP ASP A . n 
A 1 329 ALA 329 329 329 ALA ALA A . n 
A 1 330 VAL 330 330 330 VAL VAL A . n 
A 1 331 THR 331 331 331 THR THR A . n 
A 1 332 GLY 332 332 332 GLY GLY A . n 
A 1 333 LEU 333 333 333 LEU LEU A . n 
A 1 334 LYS 334 334 334 LYS LYS A . n 
A 1 335 LEU 335 335 335 LEU LEU A . n 
A 1 336 VAL 336 336 336 VAL VAL A . n 
A 1 337 GLU 337 337 337 GLU GLU A . n 
A 1 338 GLU 338 338 338 GLU GLU A . n 
A 1 339 GLY 339 339 339 GLY GLY A . n 
A 1 340 VAL 340 340 340 VAL VAL A . n 
A 1 341 PRO 341 341 341 PRO PRO A . n 
A 1 342 LYS 342 342 342 LYS LYS A . n 
A 1 343 GLU 343 343 343 GLU GLU A . n 
A 1 344 HIS 344 344 344 HIS HIS A . n 
A 1 345 LEU 345 345 345 LEU LEU A . n 
A 1 346 ALA 346 346 346 ALA ALA A . n 
A 1 347 LEU 347 347 347 LEU LEU A . n 
A 1 348 LEU 348 348 348 LEU LEU A . n 
A 1 349 ALA 349 349 349 ALA ALA A . n 
A 1 350 VAL 350 350 350 VAL VAL A . n 
A 1 351 PRO 351 351 351 PRO PRO A . n 
A 1 352 MET 352 352 352 MET MET A . n 
A 1 353 VAL 353 353 353 VAL VAL A . n 
A 1 354 PRO 354 354 354 PRO PRO A . n 
A 1 355 LEU 355 355 355 LEU LEU A . n 
A 1 356 GLN 356 356 356 GLN GLN A . n 
A 1 357 ILE 357 357 357 ILE ILE A . n 
A 1 358 ILE 358 358 358 ILE ILE A . n 
A 1 359 LEU 359 359 359 LEU LEU A . n 
A 1 360 PRO 360 360 360 PRO PRO A . n 
A 1 361 LEU 361 361 361 LEU LEU A . n 
A 1 362 ILE 362 362 362 ILE ILE A . n 
A 1 363 ILE 363 363 363 ILE ILE A . n 
A 1 364 SER 364 364 364 SER SER A . n 
A 1 365 LYS 365 365 365 LYS LYS A . n 
A 1 366 TYR 366 366 366 TYR TYR A . n 
A 1 367 THR 367 367 367 THR THR A . n 
A 1 368 ALA 368 368 368 ALA ALA A . n 
A 1 369 GLY 369 369 369 GLY GLY A . n 
A 1 370 PRO 370 370 370 PRO PRO A . n 
A 1 371 GLN 371 371 371 GLN GLN A . n 
A 1 372 PRO 372 372 372 PRO PRO A . n 
A 1 373 LEU 373 373 373 LEU LEU A . n 
A 1 374 ASN 374 374 374 ASN ASN A . n 
A 1 375 THR 375 375 375 THR THR A . n 
A 1 376 PHE 376 376 376 PHE PHE A . n 
A 1 377 TYR 377 377 377 TYR TYR A . n 
A 1 378 LYS 378 378 378 LYS LYS A . n 
A 1 379 ALA 379 379 379 ALA ALA A . n 
A 1 380 MET 380 380 380 MET MET A . n 
A 1 381 PRO 381 381 381 PRO PRO A . n 
A 1 382 TYR 382 382 382 TYR TYR A . n 
A 1 383 ARG 383 383 383 ARG ARG A . n 
A 1 384 LEU 384 384 384 LEU LEU A . n 
A 1 385 LEU 385 385 385 LEU LEU A . n 
A 1 386 LEU 386 386 386 LEU LEU A . n 
A 1 387 GLY 387 387 387 GLY GLY A . n 
A 1 388 LEU 388 388 388 LEU LEU A . n 
A 1 389 GLU 389 389 389 GLU GLU A . n 
A 1 390 TYR 390 390 390 TYR TYR A . n 
A 1 391 ALA 391 391 391 ALA ALA A . n 
A 1 392 LEU 392 392 392 LEU LEU A . n 
A 1 393 LEU 393 393 393 LEU LEU A . n 
A 1 394 VAL 394 394 394 VAL VAL A . n 
A 1 395 TRP 395 395 395 TRP TRP A . n 
A 1 396 TRP 396 396 396 TRP TRP A . n 
A 1 397 THR 397 397 397 THR THR A . n 
A 1 398 PRO 398 398 398 PRO PRO A . n 
A 1 399 LYS 399 399 399 LYS LYS A . n 
A 1 400 VAL 400 400 400 VAL VAL A . n 
A 1 401 GLU 401 401 401 GLU GLU A . n 
A 1 402 HIS 402 402 402 HIS HIS A . n 
A 1 403 GLN 403 403 403 GLN GLN A . n 
A 1 404 GLY 404 404 404 GLY GLY A . n 
A 1 405 GLY 405 405 405 GLY GLY A . n 
A 1 406 PHE 406 406 406 PHE PHE A . n 
A 1 407 PRO 407 407 407 PRO PRO A . n 
A 1 408 ILE 408 408 408 ILE ILE A . n 
A 1 409 TYR 409 409 409 TYR TYR A . n 
A 1 410 TYR 410 410 410 TYR TYR A . n 
A 1 411 TYR 411 411 411 TYR TYR A . n 
A 1 412 ILE 412 412 412 ILE ILE A . n 
A 1 413 VAL 413 413 413 VAL VAL A . n 
A 1 414 VAL 414 414 414 VAL VAL A . n 
A 1 415 LEU 415 415 415 LEU LEU A . n 
A 1 416 LEU 416 416 416 LEU LEU A . n 
A 1 417 SER 417 417 417 SER SER A . n 
A 1 418 TYR 418 418 418 TYR TYR A . n 
A 1 419 ALA 419 419 419 ALA ALA A . n 
A 1 420 LEU 420 420 420 LEU LEU A . n 
A 1 421 HIS 421 421 421 HIS HIS A . n 
A 1 422 GLN 422 422 422 GLN GLN A . n 
A 1 423 VAL 423 423 423 VAL VAL A . n 
A 1 424 THR 424 424 424 THR THR A . n 
A 1 425 VAL 425 425 425 VAL VAL A . n 
A 1 426 TYR 426 426 426 TYR TYR A . n 
A 1 427 SER 427 427 427 SER SER A . n 
A 1 428 MET 428 428 428 MET MET A . n 
A 1 429 TYR 429 429 429 TYR TYR A . n 
A 1 430 VAL 430 430 430 VAL VAL A . n 
A 1 431 SER 431 431 431 SER SER A . n 
A 1 432 ILE 432 432 432 ILE ILE A . n 
A 1 433 MET 433 433 433 MET MET A . n 
A 1 434 ALA 434 434 434 ALA ALA A . n 
A 1 435 PHE 435 435 435 PHE PHE A . n 
A 1 436 ASN 436 436 436 ASN ASN A . n 
A 1 437 ALA 437 437 437 ALA ALA A . n 
A 1 438 LYS 438 438 438 LYS LYS A . n 
A 1 439 VAL 439 439 439 VAL VAL A . n 
A 1 440 SER 440 440 440 SER SER A . n 
A 1 441 ASP 441 441 441 ASP ASP A . n 
A 1 442 PRO 442 442 442 PRO PRO A . n 
A 1 443 LEU 443 443 443 LEU LEU A . n 
A 1 444 ILE 444 444 444 ILE ILE A . n 
A 1 445 GLY 445 445 445 GLY GLY A . n 
A 1 446 GLY 446 446 446 GLY GLY A . n 
A 1 447 THR 447 447 447 THR THR A . n 
A 1 448 TYR 448 448 448 TYR TYR A . n 
A 1 449 MET 449 449 449 MET MET A . n 
A 1 450 THR 450 450 450 THR THR A . n 
A 1 451 LEU 451 451 451 LEU LEU A . n 
A 1 452 LEU 452 452 452 LEU LEU A . n 
A 1 453 ASN 453 453 453 ASN ASN A . n 
A 1 454 THR 454 454 454 THR THR A . n 
A 1 455 VAL 455 455 455 VAL VAL A . n 
A 1 456 SER 456 456 456 SER SER A . n 
A 1 457 ASN 457 457 457 ASN ASN A . n 
A 1 458 LEU 458 458 458 LEU LEU A . n 
A 1 459 GLY 459 459 459 GLY GLY A . n 
A 1 460 GLY 460 460 460 GLY GLY A . n 
A 1 461 ASN 461 461 461 ASN ASN A . n 
A 1 462 TRP 462 462 462 TRP TRP A . n 
A 1 463 PRO 463 463 463 PRO PRO A . n 
A 1 464 SER 464 464 464 SER SER A . n 
A 1 465 THR 465 465 465 THR THR A . n 
A 1 466 VAL 466 466 466 VAL VAL A . n 
A 1 467 ALA 467 467 467 ALA ALA A . n 
A 1 468 LEU 468 468 468 LEU LEU A . n 
A 1 469 TRP 469 469 469 TRP TRP A . n 
A 1 470 LEU 470 470 470 LEU LEU A . n 
A 1 471 VAL 471 471 471 VAL VAL A . n 
A 1 472 ASP 472 472 472 ASP ASP A . n 
A 1 473 PRO 473 473 473 PRO PRO A . n 
A 1 474 LEU 474 474 474 LEU LEU A . n 
A 1 475 THR 475 475 475 THR THR A . n 
A 1 476 VAL 476 476 476 VAL VAL A . n 
A 1 477 LYS 477 477 ?   ?   ?   A . n 
A 1 478 GLU 478 478 ?   ?   ?   A . n 
A 1 479 CYS 479 479 ?   ?   ?   A . n 
A 1 480 VAL 480 480 ?   ?   ?   A . n 
A 1 481 GLY 481 481 ?   ?   ?   A . n 
A 1 482 ALA 482 482 ?   ?   ?   A . n 
A 1 483 SER 483 483 ?   ?   ?   A . n 
A 1 484 ASN 484 484 ?   ?   ?   A . n 
A 1 485 GLN 485 485 ?   ?   ?   A . n 
A 1 486 ASN 486 486 ?   ?   ?   A . n 
A 1 487 CYS 487 487 ?   ?   ?   A . n 
A 1 488 ARG 488 488 ?   ?   ?   A . n 
A 1 489 THR 489 489 ?   ?   ?   A . n 
A 1 490 PRO 490 490 ?   ?   ?   A . n 
A 1 491 ASP 491 491 ?   ?   ?   A . n 
A 1 492 ALA 492 492 ?   ?   ?   A . n 
A 1 493 VAL 493 493 ?   ?   ?   A . n 
A 1 494 GLU 494 494 ?   ?   ?   A . n 
A 1 495 LEU 495 495 ?   ?   ?   A . n 
A 1 496 CYS 496 496 ?   ?   ?   A . n 
A 1 497 LYS 497 497 ?   ?   ?   A . n 
A 1 498 LYS 498 498 ?   ?   ?   A . n 
A 1 499 LEU 499 499 ?   ?   ?   A . n 
A 1 500 GLY 500 500 ?   ?   ?   A . n 
A 1 501 GLY 501 501 ?   ?   ?   A . n 
A 1 502 SER 502 502 ?   ?   ?   A . n 
A 1 503 CYS 503 503 ?   ?   ?   A . n 
A 1 504 VAL 504 504 ?   ?   ?   A . n 
A 1 505 THR 505 505 505 THR THR A . n 
A 1 506 ALA 506 506 506 ALA ALA A . n 
A 1 507 LEU 507 507 507 LEU LEU A . n 
A 1 508 ASP 508 508 508 ASP ASP A . n 
A 1 509 GLY 509 509 509 GLY GLY A . n 
A 1 510 TYR 510 510 510 TYR TYR A . n 
A 1 511 TYR 511 511 511 TYR TYR A . n 
A 1 512 VAL 512 512 512 VAL VAL A . n 
A 1 513 GLU 513 513 513 GLU GLU A . n 
A 1 514 SER 514 514 514 SER SER A . n 
A 1 515 ILE 515 515 515 ILE ILE A . n 
A 1 516 ILE 516 516 516 ILE ILE A . n 
A 1 517 CYS 517 517 517 CYS CYS A . n 
A 1 518 VAL 518 518 518 VAL VAL A . n 
A 1 519 PHE 519 519 519 PHE PHE A . n 
A 1 520 ILE 520 520 520 ILE ILE A . n 
A 1 521 GLY 521 521 521 GLY GLY A . n 
A 1 522 PHE 522 522 522 PHE PHE A . n 
A 1 523 GLY 523 523 523 GLY GLY A . n 
A 1 524 TRP 524 524 524 TRP TRP A . n 
A 1 525 TRP 525 525 525 TRP TRP A . n 
A 1 526 PHE 526 526 526 PHE PHE A . n 
A 1 527 PHE 527 527 527 PHE PHE A . n 
A 1 528 LEU 528 528 528 LEU LEU A . n 
A 1 529 GLY 529 529 529 GLY GLY A . n 
A 1 530 PRO 530 530 530 PRO PRO A . n 
A 1 531 LYS 531 531 531 LYS LYS A . n 
A 1 532 PHE 532 532 532 PHE PHE A . n 
A 1 533 LYS 533 533 533 LYS LYS A . n 
A 1 534 LYS 534 534 534 LYS LYS A . n 
A 1 535 LEU 535 535 535 LEU LEU A . n 
A 1 536 GLN 536 536 536 GLN GLN A . n 
A 1 537 ASP 537 537 537 ASP ASP A . n 
A 1 538 GLU 538 538 ?   ?   ?   A . n 
A 1 539 GLY 539 539 ?   ?   ?   A . n 
A 1 540 SER 540 540 ?   ?   ?   A . n 
A 1 541 SER 541 541 ?   ?   ?   A . n 
A 1 542 SER 542 542 ?   ?   ?   A . n 
A 1 543 TRP 543 543 ?   ?   ?   A . n 
A 1 544 LYS 544 544 ?   ?   ?   A . n 
A 1 545 CYS 545 545 ?   ?   ?   A . n 
A 1 546 LYS 546 546 ?   ?   ?   A . n 
A 1 547 ARG 547 547 ?   ?   ?   A . n 
A 1 548 ASN 548 548 ?   ?   ?   A . n 
A 1 549 ASN 549 549 ?   ?   ?   A . n 
A 1 550 LEU 550 550 ?   ?   ?   A . n 
A 1 551 GLU 551 551 ?   ?   ?   A . n 
A 1 552 GLY 552 552 ?   ?   ?   A . n 
A 1 553 GLY 553 553 ?   ?   ?   A . n 
A 1 554 SER 554 554 ?   ?   ?   A . n 
A 1 555 LEU 555 555 ?   ?   ?   A . n 
A 1 556 GLU 556 556 ?   ?   ?   A . n 
A 1 557 VAL 557 557 ?   ?   ?   A . n 
A 1 558 LEU 558 558 ?   ?   ?   A . n 
A 1 559 PHE 559 559 ?   ?   ?   A . n 
A 1 560 GLN 560 560 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        ACO 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   ACO 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
_pdbx_nonpoly_scheme.asym_id         B 
_pdbx_nonpoly_scheme.entity_id       2 
_pdbx_nonpoly_scheme.mon_id          ACO 
_pdbx_nonpoly_scheme.ndb_seq_num     1 
_pdbx_nonpoly_scheme.pdb_seq_num     601 
_pdbx_nonpoly_scheme.auth_seq_num    601 
_pdbx_nonpoly_scheme.pdb_mon_id      ACO 
_pdbx_nonpoly_scheme.auth_mon_id     ACO 
_pdbx_nonpoly_scheme.pdb_strand_id   A 
_pdbx_nonpoly_scheme.pdb_ins_code    . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9M0S 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9M0S 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9M0S 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 9M0S 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.007  ? 3512 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 1.090  ? 4809 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 11.088 ? 1202 ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.065  ? 565  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.009  ? 574  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     9M0S 
_struct.title                        'Acetyl-CoA-bound SLC33A1 in a cytoplasm-facing conformation' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9M0S 
_struct_keywords.text            'SLC33A1; AT1; Acetyl-CoA, TRANSPORT PROTEIN' 
_struct_keywords.pdbx_keywords   'TRANSPORT PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    ACATN_HUMAN 
_struct_ref.pdbx_db_accession          O00400 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGDFLKAPQSFRAELSSILLLLF
LYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLST
QVDRLLGNTDDRTPDVIALTVAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADF
CNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVKEETQGITDTYKLLFAIIKMPAVLTFCLLILTA
KIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILPLIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKV
EHQGGFPIYYYIVVLLSYALHQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECV
GASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFLGPKFKKLQDEGSSSWKCKRNN
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9M0S 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 549 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             O00400 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  549 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       549 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9M0S LEU A 550 ? UNP O00400 ? ? 'expression tag' 550 1  
1 9M0S GLU A 551 ? UNP O00400 ? ? 'expression tag' 551 2  
1 9M0S GLY A 552 ? UNP O00400 ? ? 'expression tag' 552 3  
1 9M0S GLY A 553 ? UNP O00400 ? ? 'expression tag' 553 4  
1 9M0S SER A 554 ? UNP O00400 ? ? 'expression tag' 554 5  
1 9M0S LEU A 555 ? UNP O00400 ? ? 'expression tag' 555 6  
1 9M0S GLU A 556 ? UNP O00400 ? ? 'expression tag' 556 7  
1 9M0S VAL A 557 ? UNP O00400 ? ? 'expression tag' 557 8  
1 9M0S LEU A 558 ? UNP O00400 ? ? 'expression tag' 558 9  
1 9M0S PHE A 559 ? UNP O00400 ? ? 'expression tag' 559 10 
1 9M0S GLN A 560 ? UNP O00400 ? ? 'expression tag' 560 11 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLU A 71  ? LYS A 102 ? GLU A 71  LYS A 102 1 ? 32 
HELX_P HELX_P2  AA2 SER A 105 ? SER A 113 ? SER A 105 SER A 113 1 ? 9  
HELX_P HELX_P3  AA3 PHE A 116 ? LEU A 121 ? PHE A 116 LEU A 121 1 ? 6  
HELX_P HELX_P4  AA4 LYS A 122 ? LEU A 124 ? LYS A 122 LEU A 124 5 ? 3  
HELX_P HELX_P5  AA5 TRP A 125 ? ALA A 131 ? TRP A 125 ALA A 131 1 ? 7  
HELX_P HELX_P6  AA6 LEU A 144 ? LEU A 166 ? LEU A 144 LEU A 166 1 ? 23 
HELX_P HELX_P7  AA7 ASP A 175 ? LEU A 205 ? ASP A 175 LEU A 205 1 ? 31 
HELX_P HELX_P8  AA8 ASN A 209 ? VAL A 230 ? ASN A 209 VAL A 230 1 ? 22 
HELX_P HELX_P9  AA9 VAL A 230 ? LEU A 235 ? VAL A 230 LEU A 235 1 ? 6  
HELX_P HELX_P10 AB1 SER A 237 ? TYR A 244 ? SER A 237 TYR A 244 1 ? 8  
HELX_P HELX_P11 AB2 THR A 256 ? LEU A 278 ? THR A 256 LEU A 278 1 ? 23 
HELX_P HELX_P12 AB3 THR A 295 ? MET A 307 ? THR A 295 MET A 307 1 ? 13 
HELX_P HELX_P13 AB4 MET A 307 ? LYS A 321 ? MET A 307 LYS A 321 1 ? 15 
HELX_P HELX_P14 AB5 LYS A 321 ? GLY A 339 ? LYS A 321 GLY A 339 1 ? 19 
HELX_P HELX_P15 AB6 PRO A 341 ? LEU A 348 ? PRO A 341 LEU A 348 1 ? 8  
HELX_P HELX_P16 AB7 PRO A 351 ? ILE A 363 ? PRO A 351 ILE A 363 1 ? 13 
HELX_P HELX_P17 AB8 ILE A 363 ? GLY A 369 ? ILE A 363 GLY A 369 1 ? 7  
HELX_P HELX_P18 AB9 LEU A 373 ? THR A 397 ? LEU A 373 THR A 397 1 ? 25 
HELX_P HELX_P19 AC1 PRO A 398 ? VAL A 400 ? PRO A 398 VAL A 400 5 ? 3  
HELX_P HELX_P20 AC2 PRO A 407 ? SER A 440 ? PRO A 407 SER A 440 1 ? 34 
HELX_P HELX_P21 AC3 ILE A 444 ? LEU A 470 ? ILE A 444 LEU A 470 1 ? 27 
HELX_P HELX_P22 AC4 VAL A 471 ? THR A 475 ? VAL A 471 THR A 475 5 ? 5  
HELX_P HELX_P23 AC5 ASP A 508 ? LEU A 535 ? ASP A 508 LEU A 535 1 ? 28 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_pdbx_entry_details.entry_id                   9M0S 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 SER A 113 ? ? -67.80 2.33  
2 1 GLN A 248 ? ? 53.83  77.55 
3 1 ARG A 252 ? ? 55.43  16.50 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9M0S 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9M0S 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.5 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               238758 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.25 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'SLC33A1 in complex with acetyl-CoA' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        9M0S 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI POLARA 300' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1000 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
_em_imaging.objective_aperture              ? 
_em_imaging.microscope_serial_number        ? 
_em_imaging.microscope_version              ? 
# 
_em_vitrification.entry_id              9M0S 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9M0S 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET 1   ? A MET 1   
2   1 Y 1 A SER 2   ? A SER 2   
3   1 Y 1 A PRO 3   ? A PRO 3   
4   1 Y 1 A THR 4   ? A THR 4   
5   1 Y 1 A ILE 5   ? A ILE 5   
6   1 Y 1 A SER 6   ? A SER 6   
7   1 Y 1 A HIS 7   ? A HIS 7   
8   1 Y 1 A LYS 8   ? A LYS 8   
9   1 Y 1 A ASP 9   ? A ASP 9   
10  1 Y 1 A SER 10  ? A SER 10  
11  1 Y 1 A SER 11  ? A SER 11  
12  1 Y 1 A ARG 12  ? A ARG 12  
13  1 Y 1 A GLN 13  ? A GLN 13  
14  1 Y 1 A ARG 14  ? A ARG 14  
15  1 Y 1 A ARG 15  ? A ARG 15  
16  1 Y 1 A PRO 16  ? A PRO 16  
17  1 Y 1 A GLY 17  ? A GLY 17  
18  1 Y 1 A ASN 18  ? A ASN 18  
19  1 Y 1 A PHE 19  ? A PHE 19  
20  1 Y 1 A SER 20  ? A SER 20  
21  1 Y 1 A HIS 21  ? A HIS 21  
22  1 Y 1 A SER 22  ? A SER 22  
23  1 Y 1 A LEU 23  ? A LEU 23  
24  1 Y 1 A ASP 24  ? A ASP 24  
25  1 Y 1 A MET 25  ? A MET 25  
26  1 Y 1 A LYS 26  ? A LYS 26  
27  1 Y 1 A SER 27  ? A SER 27  
28  1 Y 1 A GLY 28  ? A GLY 28  
29  1 Y 1 A PRO 29  ? A PRO 29  
30  1 Y 1 A LEU 30  ? A LEU 30  
31  1 Y 1 A PRO 31  ? A PRO 31  
32  1 Y 1 A PRO 32  ? A PRO 32  
33  1 Y 1 A GLY 33  ? A GLY 33  
34  1 Y 1 A GLY 34  ? A GLY 34  
35  1 Y 1 A TRP 35  ? A TRP 35  
36  1 Y 1 A ASP 36  ? A ASP 36  
37  1 Y 1 A ASP 37  ? A ASP 37  
38  1 Y 1 A SER 38  ? A SER 38  
39  1 Y 1 A HIS 39  ? A HIS 39  
40  1 Y 1 A LEU 40  ? A LEU 40  
41  1 Y 1 A ASP 41  ? A ASP 41  
42  1 Y 1 A SER 42  ? A SER 42  
43  1 Y 1 A ALA 43  ? A ALA 43  
44  1 Y 1 A GLY 44  ? A GLY 44  
45  1 Y 1 A ARG 45  ? A ARG 45  
46  1 Y 1 A GLU 46  ? A GLU 46  
47  1 Y 1 A GLY 47  ? A GLY 47  
48  1 Y 1 A ASP 48  ? A ASP 48  
49  1 Y 1 A ARG 49  ? A ARG 49  
50  1 Y 1 A GLU 50  ? A GLU 50  
51  1 Y 1 A ALA 51  ? A ALA 51  
52  1 Y 1 A LEU 52  ? A LEU 52  
53  1 Y 1 A LEU 53  ? A LEU 53  
54  1 Y 1 A GLY 54  ? A GLY 54  
55  1 Y 1 A ASP 55  ? A ASP 55  
56  1 Y 1 A THR 56  ? A THR 56  
57  1 Y 1 A GLY 57  ? A GLY 57  
58  1 Y 1 A THR 58  ? A THR 58  
59  1 Y 1 A GLY 59  ? A GLY 59  
60  1 Y 1 A ASP 60  ? A ASP 60  
61  1 Y 1 A PHE 61  ? A PHE 61  
62  1 Y 1 A LEU 62  ? A LEU 62  
63  1 Y 1 A LYS 63  ? A LYS 63  
64  1 Y 1 A ALA 64  ? A ALA 64  
65  1 Y 1 A PRO 65  ? A PRO 65  
66  1 Y 1 A GLN 66  ? A GLN 66  
67  1 Y 1 A SER 67  ? A SER 67  
68  1 Y 1 A PHE 68  ? A PHE 68  
69  1 Y 1 A ARG 69  ? A ARG 69  
70  1 Y 1 A ALA 70  ? A ALA 70  
71  1 Y 1 A LYS 279 ? A LYS 279 
72  1 Y 1 A LYS 280 ? A LYS 280 
73  1 Y 1 A GLU 281 ? A GLU 281 
74  1 Y 1 A ASN 282 ? A ASN 282 
75  1 Y 1 A GLU 283 ? A GLU 283 
76  1 Y 1 A VAL 284 ? A VAL 284 
77  1 Y 1 A SER 285 ? A SER 285 
78  1 Y 1 A VAL 286 ? A VAL 286 
79  1 Y 1 A VAL 287 ? A VAL 287 
80  1 Y 1 A LYS 288 ? A LYS 288 
81  1 Y 1 A GLU 289 ? A GLU 289 
82  1 Y 1 A GLU 290 ? A GLU 290 
83  1 Y 1 A THR 291 ? A THR 291 
84  1 Y 1 A GLN 292 ? A GLN 292 
85  1 Y 1 A GLY 293 ? A GLY 293 
86  1 Y 1 A LYS 477 ? A LYS 477 
87  1 Y 1 A GLU 478 ? A GLU 478 
88  1 Y 1 A CYS 479 ? A CYS 479 
89  1 Y 1 A VAL 480 ? A VAL 480 
90  1 Y 1 A GLY 481 ? A GLY 481 
91  1 Y 1 A ALA 482 ? A ALA 482 
92  1 Y 1 A SER 483 ? A SER 483 
93  1 Y 1 A ASN 484 ? A ASN 484 
94  1 Y 1 A GLN 485 ? A GLN 485 
95  1 Y 1 A ASN 486 ? A ASN 486 
96  1 Y 1 A CYS 487 ? A CYS 487 
97  1 Y 1 A ARG 488 ? A ARG 488 
98  1 Y 1 A THR 489 ? A THR 489 
99  1 Y 1 A PRO 490 ? A PRO 490 
100 1 Y 1 A ASP 491 ? A ASP 491 
101 1 Y 1 A ALA 492 ? A ALA 492 
102 1 Y 1 A VAL 493 ? A VAL 493 
103 1 Y 1 A GLU 494 ? A GLU 494 
104 1 Y 1 A LEU 495 ? A LEU 495 
105 1 Y 1 A CYS 496 ? A CYS 496 
106 1 Y 1 A LYS 497 ? A LYS 497 
107 1 Y 1 A LYS 498 ? A LYS 498 
108 1 Y 1 A LEU 499 ? A LEU 499 
109 1 Y 1 A GLY 500 ? A GLY 500 
110 1 Y 1 A GLY 501 ? A GLY 501 
111 1 Y 1 A SER 502 ? A SER 502 
112 1 Y 1 A CYS 503 ? A CYS 503 
113 1 Y 1 A VAL 504 ? A VAL 504 
114 1 Y 1 A GLU 538 ? A GLU 538 
115 1 Y 1 A GLY 539 ? A GLY 539 
116 1 Y 1 A SER 540 ? A SER 540 
117 1 Y 1 A SER 541 ? A SER 541 
118 1 Y 1 A SER 542 ? A SER 542 
119 1 Y 1 A TRP 543 ? A TRP 543 
120 1 Y 1 A LYS 544 ? A LYS 544 
121 1 Y 1 A CYS 545 ? A CYS 545 
122 1 Y 1 A LYS 546 ? A LYS 546 
123 1 Y 1 A ARG 547 ? A ARG 547 
124 1 Y 1 A ASN 548 ? A ASN 548 
125 1 Y 1 A ASN 549 ? A ASN 549 
126 1 Y 1 A LEU 550 ? A LEU 550 
127 1 Y 1 A GLU 551 ? A GLU 551 
128 1 Y 1 A GLY 552 ? A GLY 552 
129 1 Y 1 A GLY 553 ? A GLY 553 
130 1 Y 1 A SER 554 ? A SER 554 
131 1 Y 1 A LEU 555 ? A LEU 555 
132 1 Y 1 A GLU 556 ? A GLU 556 
133 1 Y 1 A VAL 557 ? A VAL 557 
134 1 Y 1 A LEU 558 ? A LEU 558 
135 1 Y 1 A PHE 559 ? A PHE 559 
136 1 Y 1 A GLN 560 ? A GLN 560 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ACO N1A  N Y N 1   
ACO C2A  C Y N 2   
ACO N3A  N Y N 3   
ACO C4A  C Y N 4   
ACO C5A  C Y N 5   
ACO C6A  C Y N 6   
ACO N6A  N N N 7   
ACO N7A  N Y N 8   
ACO C8A  C Y N 9   
ACO N9A  N Y N 10  
ACO C1B  C N R 11  
ACO C2B  C N R 12  
ACO O2B  O N N 13  
ACO C3B  C N S 14  
ACO O3B  O N N 15  
ACO P3B  P N N 16  
ACO O7A  O N N 17  
ACO O8A  O N N 18  
ACO O9A  O N N 19  
ACO C4B  C N R 20  
ACO O4B  O N N 21  
ACO C5B  C N N 22  
ACO O5B  O N N 23  
ACO P1A  P N S 24  
ACO O1A  O N N 25  
ACO O2A  O N N 26  
ACO O3A  O N N 27  
ACO P2A  P N S 28  
ACO O4A  O N N 29  
ACO O5A  O N N 30  
ACO O6A  O N N 31  
ACO CBP  C N N 32  
ACO CCP  C N N 33  
ACO CDP  C N N 34  
ACO CEP  C N N 35  
ACO CAP  C N R 36  
ACO OAP  O N N 37  
ACO C9P  C N N 38  
ACO O9P  O N N 39  
ACO N8P  N N N 40  
ACO C7P  C N N 41  
ACO C6P  C N N 42  
ACO C5P  C N N 43  
ACO O5P  O N N 44  
ACO N4P  N N N 45  
ACO C3P  C N N 46  
ACO C2P  C N N 47  
ACO S1P  S N N 48  
ACO C    C N N 49  
ACO O    O N N 50  
ACO CH3  C N N 51  
ACO H2A  H N N 52  
ACO H61A H N N 53  
ACO H62A H N N 54  
ACO H8A  H N N 55  
ACO H1B  H N N 56  
ACO H2B  H N N 57  
ACO HO2A H N N 58  
ACO H3B  H N N 59  
ACO HOA8 H N N 60  
ACO HOA9 H N N 61  
ACO H4B  H N N 62  
ACO H51A H N N 63  
ACO H52A H N N 64  
ACO HOA2 H N N 65  
ACO HOA5 H N N 66  
ACO H121 H N N 67  
ACO H122 H N N 68  
ACO H131 H N N 69  
ACO H132 H N N 70  
ACO H133 H N N 71  
ACO H141 H N N 72  
ACO H142 H N N 73  
ACO H143 H N N 74  
ACO H10  H N N 75  
ACO HO1  H N N 76  
ACO HN8  H N N 77  
ACO H71  H N N 78  
ACO H72  H N N 79  
ACO H61  H N N 80  
ACO H62  H N N 81  
ACO HN4  H N N 82  
ACO H31  H N N 83  
ACO H32  H N N 84  
ACO H21  H N N 85  
ACO H22  H N N 86  
ACO HH31 H N N 87  
ACO HH32 H N N 88  
ACO HH33 H N N 89  
ALA N    N N N 90  
ALA CA   C N S 91  
ALA C    C N N 92  
ALA O    O N N 93  
ALA CB   C N N 94  
ALA OXT  O N N 95  
ALA H    H N N 96  
ALA H2   H N N 97  
ALA HA   H N N 98  
ALA HB1  H N N 99  
ALA HB2  H N N 100 
ALA HB3  H N N 101 
ALA HXT  H N N 102 
ARG N    N N N 103 
ARG CA   C N S 104 
ARG C    C N N 105 
ARG O    O N N 106 
ARG CB   C N N 107 
ARG CG   C N N 108 
ARG CD   C N N 109 
ARG NE   N N N 110 
ARG CZ   C N N 111 
ARG NH1  N N N 112 
ARG NH2  N N N 113 
ARG OXT  O N N 114 
ARG H    H N N 115 
ARG H2   H N N 116 
ARG HA   H N N 117 
ARG HB2  H N N 118 
ARG HB3  H N N 119 
ARG HG2  H N N 120 
ARG HG3  H N N 121 
ARG HD2  H N N 122 
ARG HD3  H N N 123 
ARG HE   H N N 124 
ARG HH11 H N N 125 
ARG HH12 H N N 126 
ARG HH21 H N N 127 
ARG HH22 H N N 128 
ARG HXT  H N N 129 
ASN N    N N N 130 
ASN CA   C N S 131 
ASN C    C N N 132 
ASN O    O N N 133 
ASN CB   C N N 134 
ASN CG   C N N 135 
ASN OD1  O N N 136 
ASN ND2  N N N 137 
ASN OXT  O N N 138 
ASN H    H N N 139 
ASN H2   H N N 140 
ASN HA   H N N 141 
ASN HB2  H N N 142 
ASN HB3  H N N 143 
ASN HD21 H N N 144 
ASN HD22 H N N 145 
ASN HXT  H N N 146 
ASP N    N N N 147 
ASP CA   C N S 148 
ASP C    C N N 149 
ASP O    O N N 150 
ASP CB   C N N 151 
ASP CG   C N N 152 
ASP OD1  O N N 153 
ASP OD2  O N N 154 
ASP OXT  O N N 155 
ASP H    H N N 156 
ASP H2   H N N 157 
ASP HA   H N N 158 
ASP HB2  H N N 159 
ASP HB3  H N N 160 
ASP HD2  H N N 161 
ASP HXT  H N N 162 
CYS N    N N N 163 
CYS CA   C N R 164 
CYS C    C N N 165 
CYS O    O N N 166 
CYS CB   C N N 167 
CYS SG   S N N 168 
CYS OXT  O N N 169 
CYS H    H N N 170 
CYS H2   H N N 171 
CYS HA   H N N 172 
CYS HB2  H N N 173 
CYS HB3  H N N 174 
CYS HG   H N N 175 
CYS HXT  H N N 176 
GLN N    N N N 177 
GLN CA   C N S 178 
GLN C    C N N 179 
GLN O    O N N 180 
GLN CB   C N N 181 
GLN CG   C N N 182 
GLN CD   C N N 183 
GLN OE1  O N N 184 
GLN NE2  N N N 185 
GLN OXT  O N N 186 
GLN H    H N N 187 
GLN H2   H N N 188 
GLN HA   H N N 189 
GLN HB2  H N N 190 
GLN HB3  H N N 191 
GLN HG2  H N N 192 
GLN HG3  H N N 193 
GLN HE21 H N N 194 
GLN HE22 H N N 195 
GLN HXT  H N N 196 
GLU N    N N N 197 
GLU CA   C N S 198 
GLU C    C N N 199 
GLU O    O N N 200 
GLU CB   C N N 201 
GLU CG   C N N 202 
GLU CD   C N N 203 
GLU OE1  O N N 204 
GLU OE2  O N N 205 
GLU OXT  O N N 206 
GLU H    H N N 207 
GLU H2   H N N 208 
GLU HA   H N N 209 
GLU HB2  H N N 210 
GLU HB3  H N N 211 
GLU HG2  H N N 212 
GLU HG3  H N N 213 
GLU HE2  H N N 214 
GLU HXT  H N N 215 
GLY N    N N N 216 
GLY CA   C N N 217 
GLY C    C N N 218 
GLY O    O N N 219 
GLY OXT  O N N 220 
GLY H    H N N 221 
GLY H2   H N N 222 
GLY HA2  H N N 223 
GLY HA3  H N N 224 
GLY HXT  H N N 225 
HIS N    N N N 226 
HIS CA   C N S 227 
HIS C    C N N 228 
HIS O    O N N 229 
HIS CB   C N N 230 
HIS CG   C Y N 231 
HIS ND1  N Y N 232 
HIS CD2  C Y N 233 
HIS CE1  C Y N 234 
HIS NE2  N Y N 235 
HIS OXT  O N N 236 
HIS H    H N N 237 
HIS H2   H N N 238 
HIS HA   H N N 239 
HIS HB2  H N N 240 
HIS HB3  H N N 241 
HIS HD1  H N N 242 
HIS HD2  H N N 243 
HIS HE1  H N N 244 
HIS HE2  H N N 245 
HIS HXT  H N N 246 
ILE N    N N N 247 
ILE CA   C N S 248 
ILE C    C N N 249 
ILE O    O N N 250 
ILE CB   C N S 251 
ILE CG1  C N N 252 
ILE CG2  C N N 253 
ILE CD1  C N N 254 
ILE OXT  O N N 255 
ILE H    H N N 256 
ILE H2   H N N 257 
ILE HA   H N N 258 
ILE HB   H N N 259 
ILE HG12 H N N 260 
ILE HG13 H N N 261 
ILE HG21 H N N 262 
ILE HG22 H N N 263 
ILE HG23 H N N 264 
ILE HD11 H N N 265 
ILE HD12 H N N 266 
ILE HD13 H N N 267 
ILE HXT  H N N 268 
LEU N    N N N 269 
LEU CA   C N S 270 
LEU C    C N N 271 
LEU O    O N N 272 
LEU CB   C N N 273 
LEU CG   C N N 274 
LEU CD1  C N N 275 
LEU CD2  C N N 276 
LEU OXT  O N N 277 
LEU H    H N N 278 
LEU H2   H N N 279 
LEU HA   H N N 280 
LEU HB2  H N N 281 
LEU HB3  H N N 282 
LEU HG   H N N 283 
LEU HD11 H N N 284 
LEU HD12 H N N 285 
LEU HD13 H N N 286 
LEU HD21 H N N 287 
LEU HD22 H N N 288 
LEU HD23 H N N 289 
LEU HXT  H N N 290 
LYS N    N N N 291 
LYS CA   C N S 292 
LYS C    C N N 293 
LYS O    O N N 294 
LYS CB   C N N 295 
LYS CG   C N N 296 
LYS CD   C N N 297 
LYS CE   C N N 298 
LYS NZ   N N N 299 
LYS OXT  O N N 300 
LYS H    H N N 301 
LYS H2   H N N 302 
LYS HA   H N N 303 
LYS HB2  H N N 304 
LYS HB3  H N N 305 
LYS HG2  H N N 306 
LYS HG3  H N N 307 
LYS HD2  H N N 308 
LYS HD3  H N N 309 
LYS HE2  H N N 310 
LYS HE3  H N N 311 
LYS HZ1  H N N 312 
LYS HZ2  H N N 313 
LYS HZ3  H N N 314 
LYS HXT  H N N 315 
MET N    N N N 316 
MET CA   C N S 317 
MET C    C N N 318 
MET O    O N N 319 
MET CB   C N N 320 
MET CG   C N N 321 
MET SD   S N N 322 
MET CE   C N N 323 
MET OXT  O N N 324 
MET H    H N N 325 
MET H2   H N N 326 
MET HA   H N N 327 
MET HB2  H N N 328 
MET HB3  H N N 329 
MET HG2  H N N 330 
MET HG3  H N N 331 
MET HE1  H N N 332 
MET HE2  H N N 333 
MET HE3  H N N 334 
MET HXT  H N N 335 
PHE N    N N N 336 
PHE CA   C N S 337 
PHE C    C N N 338 
PHE O    O N N 339 
PHE CB   C N N 340 
PHE CG   C Y N 341 
PHE CD1  C Y N 342 
PHE CD2  C Y N 343 
PHE CE1  C Y N 344 
PHE CE2  C Y N 345 
PHE CZ   C Y N 346 
PHE OXT  O N N 347 
PHE H    H N N 348 
PHE H2   H N N 349 
PHE HA   H N N 350 
PHE HB2  H N N 351 
PHE HB3  H N N 352 
PHE HD1  H N N 353 
PHE HD2  H N N 354 
PHE HE1  H N N 355 
PHE HE2  H N N 356 
PHE HZ   H N N 357 
PHE HXT  H N N 358 
PRO N    N N N 359 
PRO CA   C N S 360 
PRO C    C N N 361 
PRO O    O N N 362 
PRO CB   C N N 363 
PRO CG   C N N 364 
PRO CD   C N N 365 
PRO OXT  O N N 366 
PRO H    H N N 367 
PRO HA   H N N 368 
PRO HB2  H N N 369 
PRO HB3  H N N 370 
PRO HG2  H N N 371 
PRO HG3  H N N 372 
PRO HD2  H N N 373 
PRO HD3  H N N 374 
PRO HXT  H N N 375 
SER N    N N N 376 
SER CA   C N S 377 
SER C    C N N 378 
SER O    O N N 379 
SER CB   C N N 380 
SER OG   O N N 381 
SER OXT  O N N 382 
SER H    H N N 383 
SER H2   H N N 384 
SER HA   H N N 385 
SER HB2  H N N 386 
SER HB3  H N N 387 
SER HG   H N N 388 
SER HXT  H N N 389 
THR N    N N N 390 
THR CA   C N S 391 
THR C    C N N 392 
THR O    O N N 393 
THR CB   C N R 394 
THR OG1  O N N 395 
THR CG2  C N N 396 
THR OXT  O N N 397 
THR H    H N N 398 
THR H2   H N N 399 
THR HA   H N N 400 
THR HB   H N N 401 
THR HG1  H N N 402 
THR HG21 H N N 403 
THR HG22 H N N 404 
THR HG23 H N N 405 
THR HXT  H N N 406 
TRP N    N N N 407 
TRP CA   C N S 408 
TRP C    C N N 409 
TRP O    O N N 410 
TRP CB   C N N 411 
TRP CG   C Y N 412 
TRP CD1  C Y N 413 
TRP CD2  C Y N 414 
TRP NE1  N Y N 415 
TRP CE2  C Y N 416 
TRP CE3  C Y N 417 
TRP CZ2  C Y N 418 
TRP CZ3  C Y N 419 
TRP CH2  C Y N 420 
TRP OXT  O N N 421 
TRP H    H N N 422 
TRP H2   H N N 423 
TRP HA   H N N 424 
TRP HB2  H N N 425 
TRP HB3  H N N 426 
TRP HD1  H N N 427 
TRP HE1  H N N 428 
TRP HE3  H N N 429 
TRP HZ2  H N N 430 
TRP HZ3  H N N 431 
TRP HH2  H N N 432 
TRP HXT  H N N 433 
TYR N    N N N 434 
TYR CA   C N S 435 
TYR C    C N N 436 
TYR O    O N N 437 
TYR CB   C N N 438 
TYR CG   C Y N 439 
TYR CD1  C Y N 440 
TYR CD2  C Y N 441 
TYR CE1  C Y N 442 
TYR CE2  C Y N 443 
TYR CZ   C Y N 444 
TYR OH   O N N 445 
TYR OXT  O N N 446 
TYR H    H N N 447 
TYR H2   H N N 448 
TYR HA   H N N 449 
TYR HB2  H N N 450 
TYR HB3  H N N 451 
TYR HD1  H N N 452 
TYR HD2  H N N 453 
TYR HE1  H N N 454 
TYR HE2  H N N 455 
TYR HH   H N N 456 
TYR HXT  H N N 457 
VAL N    N N N 458 
VAL CA   C N S 459 
VAL C    C N N 460 
VAL O    O N N 461 
VAL CB   C N N 462 
VAL CG1  C N N 463 
VAL CG2  C N N 464 
VAL OXT  O N N 465 
VAL H    H N N 466 
VAL H2   H N N 467 
VAL HA   H N N 468 
VAL HB   H N N 469 
VAL HG11 H N N 470 
VAL HG12 H N N 471 
VAL HG13 H N N 472 
VAL HG21 H N N 473 
VAL HG22 H N N 474 
VAL HG23 H N N 475 
VAL HXT  H N N 476 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ACO N1A C2A  sing Y N 1   
ACO N1A C6A  doub Y N 2   
ACO C2A N3A  doub Y N 3   
ACO C2A H2A  sing N N 4   
ACO N3A C4A  sing Y N 5   
ACO C4A C5A  doub Y N 6   
ACO C4A N9A  sing Y N 7   
ACO C5A C6A  sing Y N 8   
ACO C5A N7A  sing Y N 9   
ACO C6A N6A  sing N N 10  
ACO N6A H61A sing N N 11  
ACO N6A H62A sing N N 12  
ACO N7A C8A  doub Y N 13  
ACO C8A N9A  sing Y N 14  
ACO C8A H8A  sing N N 15  
ACO N9A C1B  sing N N 16  
ACO C1B C2B  sing N N 17  
ACO C1B O4B  sing N N 18  
ACO C1B H1B  sing N N 19  
ACO C2B O2B  sing N N 20  
ACO C2B C3B  sing N N 21  
ACO C2B H2B  sing N N 22  
ACO O2B HO2A sing N N 23  
ACO C3B O3B  sing N N 24  
ACO C3B C4B  sing N N 25  
ACO C3B H3B  sing N N 26  
ACO O3B P3B  sing N N 27  
ACO P3B O7A  doub N N 28  
ACO P3B O8A  sing N N 29  
ACO P3B O9A  sing N N 30  
ACO O8A HOA8 sing N N 31  
ACO O9A HOA9 sing N N 32  
ACO C4B O4B  sing N N 33  
ACO C4B C5B  sing N N 34  
ACO C4B H4B  sing N N 35  
ACO C5B O5B  sing N N 36  
ACO C5B H51A sing N N 37  
ACO C5B H52A sing N N 38  
ACO O5B P1A  sing N N 39  
ACO P1A O1A  doub N N 40  
ACO P1A O2A  sing N N 41  
ACO P1A O3A  sing N N 42  
ACO O2A HOA2 sing N N 43  
ACO O3A P2A  sing N N 44  
ACO P2A O4A  doub N N 45  
ACO P2A O5A  sing N N 46  
ACO P2A O6A  sing N N 47  
ACO O5A HOA5 sing N N 48  
ACO O6A CCP  sing N N 49  
ACO CBP CCP  sing N N 50  
ACO CBP CDP  sing N N 51  
ACO CBP CEP  sing N N 52  
ACO CBP CAP  sing N N 53  
ACO CCP H121 sing N N 54  
ACO CCP H122 sing N N 55  
ACO CDP H131 sing N N 56  
ACO CDP H132 sing N N 57  
ACO CDP H133 sing N N 58  
ACO CEP H141 sing N N 59  
ACO CEP H142 sing N N 60  
ACO CEP H143 sing N N 61  
ACO CAP OAP  sing N N 62  
ACO CAP C9P  sing N N 63  
ACO CAP H10  sing N N 64  
ACO OAP HO1  sing N N 65  
ACO C9P O9P  doub N N 66  
ACO C9P N8P  sing N N 67  
ACO N8P C7P  sing N N 68  
ACO N8P HN8  sing N N 69  
ACO C7P C6P  sing N N 70  
ACO C7P H71  sing N N 71  
ACO C7P H72  sing N N 72  
ACO C6P C5P  sing N N 73  
ACO C6P H61  sing N N 74  
ACO C6P H62  sing N N 75  
ACO C5P O5P  doub N N 76  
ACO C5P N4P  sing N N 77  
ACO N4P C3P  sing N N 78  
ACO N4P HN4  sing N N 79  
ACO C3P C2P  sing N N 80  
ACO C3P H31  sing N N 81  
ACO C3P H32  sing N N 82  
ACO C2P S1P  sing N N 83  
ACO C2P H21  sing N N 84  
ACO C2P H22  sing N N 85  
ACO S1P C    sing N N 86  
ACO C   O    doub N N 87  
ACO C   CH3  sing N N 88  
ACO CH3 HH31 sing N N 89  
ACO CH3 HH32 sing N N 90  
ACO CH3 HH33 sing N N 91  
ALA N   CA   sing N N 92  
ALA N   H    sing N N 93  
ALA N   H2   sing N N 94  
ALA CA  C    sing N N 95  
ALA CA  CB   sing N N 96  
ALA CA  HA   sing N N 97  
ALA C   O    doub N N 98  
ALA C   OXT  sing N N 99  
ALA CB  HB1  sing N N 100 
ALA CB  HB2  sing N N 101 
ALA CB  HB3  sing N N 102 
ALA OXT HXT  sing N N 103 
ARG N   CA   sing N N 104 
ARG N   H    sing N N 105 
ARG N   H2   sing N N 106 
ARG CA  C    sing N N 107 
ARG CA  CB   sing N N 108 
ARG CA  HA   sing N N 109 
ARG C   O    doub N N 110 
ARG C   OXT  sing N N 111 
ARG CB  CG   sing N N 112 
ARG CB  HB2  sing N N 113 
ARG CB  HB3  sing N N 114 
ARG CG  CD   sing N N 115 
ARG CG  HG2  sing N N 116 
ARG CG  HG3  sing N N 117 
ARG CD  NE   sing N N 118 
ARG CD  HD2  sing N N 119 
ARG CD  HD3  sing N N 120 
ARG NE  CZ   sing N N 121 
ARG NE  HE   sing N N 122 
ARG CZ  NH1  sing N N 123 
ARG CZ  NH2  doub N N 124 
ARG NH1 HH11 sing N N 125 
ARG NH1 HH12 sing N N 126 
ARG NH2 HH21 sing N N 127 
ARG NH2 HH22 sing N N 128 
ARG OXT HXT  sing N N 129 
ASN N   CA   sing N N 130 
ASN N   H    sing N N 131 
ASN N   H2   sing N N 132 
ASN CA  C    sing N N 133 
ASN CA  CB   sing N N 134 
ASN CA  HA   sing N N 135 
ASN C   O    doub N N 136 
ASN C   OXT  sing N N 137 
ASN CB  CG   sing N N 138 
ASN CB  HB2  sing N N 139 
ASN CB  HB3  sing N N 140 
ASN CG  OD1  doub N N 141 
ASN CG  ND2  sing N N 142 
ASN ND2 HD21 sing N N 143 
ASN ND2 HD22 sing N N 144 
ASN OXT HXT  sing N N 145 
ASP N   CA   sing N N 146 
ASP N   H    sing N N 147 
ASP N   H2   sing N N 148 
ASP CA  C    sing N N 149 
ASP CA  CB   sing N N 150 
ASP CA  HA   sing N N 151 
ASP C   O    doub N N 152 
ASP C   OXT  sing N N 153 
ASP CB  CG   sing N N 154 
ASP CB  HB2  sing N N 155 
ASP CB  HB3  sing N N 156 
ASP CG  OD1  doub N N 157 
ASP CG  OD2  sing N N 158 
ASP OD2 HD2  sing N N 159 
ASP OXT HXT  sing N N 160 
CYS N   CA   sing N N 161 
CYS N   H    sing N N 162 
CYS N   H2   sing N N 163 
CYS CA  C    sing N N 164 
CYS CA  CB   sing N N 165 
CYS CA  HA   sing N N 166 
CYS C   O    doub N N 167 
CYS C   OXT  sing N N 168 
CYS CB  SG   sing N N 169 
CYS CB  HB2  sing N N 170 
CYS CB  HB3  sing N N 171 
CYS SG  HG   sing N N 172 
CYS OXT HXT  sing N N 173 
GLN N   CA   sing N N 174 
GLN N   H    sing N N 175 
GLN N   H2   sing N N 176 
GLN CA  C    sing N N 177 
GLN CA  CB   sing N N 178 
GLN CA  HA   sing N N 179 
GLN C   O    doub N N 180 
GLN C   OXT  sing N N 181 
GLN CB  CG   sing N N 182 
GLN CB  HB2  sing N N 183 
GLN CB  HB3  sing N N 184 
GLN CG  CD   sing N N 185 
GLN CG  HG2  sing N N 186 
GLN CG  HG3  sing N N 187 
GLN CD  OE1  doub N N 188 
GLN CD  NE2  sing N N 189 
GLN NE2 HE21 sing N N 190 
GLN NE2 HE22 sing N N 191 
GLN OXT HXT  sing N N 192 
GLU N   CA   sing N N 193 
GLU N   H    sing N N 194 
GLU N   H2   sing N N 195 
GLU CA  C    sing N N 196 
GLU CA  CB   sing N N 197 
GLU CA  HA   sing N N 198 
GLU C   O    doub N N 199 
GLU C   OXT  sing N N 200 
GLU CB  CG   sing N N 201 
GLU CB  HB2  sing N N 202 
GLU CB  HB3  sing N N 203 
GLU CG  CD   sing N N 204 
GLU CG  HG2  sing N N 205 
GLU CG  HG3  sing N N 206 
GLU CD  OE1  doub N N 207 
GLU CD  OE2  sing N N 208 
GLU OE2 HE2  sing N N 209 
GLU OXT HXT  sing N N 210 
GLY N   CA   sing N N 211 
GLY N   H    sing N N 212 
GLY N   H2   sing N N 213 
GLY CA  C    sing N N 214 
GLY CA  HA2  sing N N 215 
GLY CA  HA3  sing N N 216 
GLY C   O    doub N N 217 
GLY C   OXT  sing N N 218 
GLY OXT HXT  sing N N 219 
HIS N   CA   sing N N 220 
HIS N   H    sing N N 221 
HIS N   H2   sing N N 222 
HIS CA  C    sing N N 223 
HIS CA  CB   sing N N 224 
HIS CA  HA   sing N N 225 
HIS C   O    doub N N 226 
HIS C   OXT  sing N N 227 
HIS CB  CG   sing N N 228 
HIS CB  HB2  sing N N 229 
HIS CB  HB3  sing N N 230 
HIS CG  ND1  sing Y N 231 
HIS CG  CD2  doub Y N 232 
HIS ND1 CE1  doub Y N 233 
HIS ND1 HD1  sing N N 234 
HIS CD2 NE2  sing Y N 235 
HIS CD2 HD2  sing N N 236 
HIS CE1 NE2  sing Y N 237 
HIS CE1 HE1  sing N N 238 
HIS NE2 HE2  sing N N 239 
HIS OXT HXT  sing N N 240 
ILE N   CA   sing N N 241 
ILE N   H    sing N N 242 
ILE N   H2   sing N N 243 
ILE CA  C    sing N N 244 
ILE CA  CB   sing N N 245 
ILE CA  HA   sing N N 246 
ILE C   O    doub N N 247 
ILE C   OXT  sing N N 248 
ILE CB  CG1  sing N N 249 
ILE CB  CG2  sing N N 250 
ILE CB  HB   sing N N 251 
ILE CG1 CD1  sing N N 252 
ILE CG1 HG12 sing N N 253 
ILE CG1 HG13 sing N N 254 
ILE CG2 HG21 sing N N 255 
ILE CG2 HG22 sing N N 256 
ILE CG2 HG23 sing N N 257 
ILE CD1 HD11 sing N N 258 
ILE CD1 HD12 sing N N 259 
ILE CD1 HD13 sing N N 260 
ILE OXT HXT  sing N N 261 
LEU N   CA   sing N N 262 
LEU N   H    sing N N 263 
LEU N   H2   sing N N 264 
LEU CA  C    sing N N 265 
LEU CA  CB   sing N N 266 
LEU CA  HA   sing N N 267 
LEU C   O    doub N N 268 
LEU C   OXT  sing N N 269 
LEU CB  CG   sing N N 270 
LEU CB  HB2  sing N N 271 
LEU CB  HB3  sing N N 272 
LEU CG  CD1  sing N N 273 
LEU CG  CD2  sing N N 274 
LEU CG  HG   sing N N 275 
LEU CD1 HD11 sing N N 276 
LEU CD1 HD12 sing N N 277 
LEU CD1 HD13 sing N N 278 
LEU CD2 HD21 sing N N 279 
LEU CD2 HD22 sing N N 280 
LEU CD2 HD23 sing N N 281 
LEU OXT HXT  sing N N 282 
LYS N   CA   sing N N 283 
LYS N   H    sing N N 284 
LYS N   H2   sing N N 285 
LYS CA  C    sing N N 286 
LYS CA  CB   sing N N 287 
LYS CA  HA   sing N N 288 
LYS C   O    doub N N 289 
LYS C   OXT  sing N N 290 
LYS CB  CG   sing N N 291 
LYS CB  HB2  sing N N 292 
LYS CB  HB3  sing N N 293 
LYS CG  CD   sing N N 294 
LYS CG  HG2  sing N N 295 
LYS CG  HG3  sing N N 296 
LYS CD  CE   sing N N 297 
LYS CD  HD2  sing N N 298 
LYS CD  HD3  sing N N 299 
LYS CE  NZ   sing N N 300 
LYS CE  HE2  sing N N 301 
LYS CE  HE3  sing N N 302 
LYS NZ  HZ1  sing N N 303 
LYS NZ  HZ2  sing N N 304 
LYS NZ  HZ3  sing N N 305 
LYS OXT HXT  sing N N 306 
MET N   CA   sing N N 307 
MET N   H    sing N N 308 
MET N   H2   sing N N 309 
MET CA  C    sing N N 310 
MET CA  CB   sing N N 311 
MET CA  HA   sing N N 312 
MET C   O    doub N N 313 
MET C   OXT  sing N N 314 
MET CB  CG   sing N N 315 
MET CB  HB2  sing N N 316 
MET CB  HB3  sing N N 317 
MET CG  SD   sing N N 318 
MET CG  HG2  sing N N 319 
MET CG  HG3  sing N N 320 
MET SD  CE   sing N N 321 
MET CE  HE1  sing N N 322 
MET CE  HE2  sing N N 323 
MET CE  HE3  sing N N 324 
MET OXT HXT  sing N N 325 
PHE N   CA   sing N N 326 
PHE N   H    sing N N 327 
PHE N   H2   sing N N 328 
PHE CA  C    sing N N 329 
PHE CA  CB   sing N N 330 
PHE CA  HA   sing N N 331 
PHE C   O    doub N N 332 
PHE C   OXT  sing N N 333 
PHE CB  CG   sing N N 334 
PHE CB  HB2  sing N N 335 
PHE CB  HB3  sing N N 336 
PHE CG  CD1  doub Y N 337 
PHE CG  CD2  sing Y N 338 
PHE CD1 CE1  sing Y N 339 
PHE CD1 HD1  sing N N 340 
PHE CD2 CE2  doub Y N 341 
PHE CD2 HD2  sing N N 342 
PHE CE1 CZ   doub Y N 343 
PHE CE1 HE1  sing N N 344 
PHE CE2 CZ   sing Y N 345 
PHE CE2 HE2  sing N N 346 
PHE CZ  HZ   sing N N 347 
PHE OXT HXT  sing N N 348 
PRO N   CA   sing N N 349 
PRO N   CD   sing N N 350 
PRO N   H    sing N N 351 
PRO CA  C    sing N N 352 
PRO CA  CB   sing N N 353 
PRO CA  HA   sing N N 354 
PRO C   O    doub N N 355 
PRO C   OXT  sing N N 356 
PRO CB  CG   sing N N 357 
PRO CB  HB2  sing N N 358 
PRO CB  HB3  sing N N 359 
PRO CG  CD   sing N N 360 
PRO CG  HG2  sing N N 361 
PRO CG  HG3  sing N N 362 
PRO CD  HD2  sing N N 363 
PRO CD  HD3  sing N N 364 
PRO OXT HXT  sing N N 365 
SER N   CA   sing N N 366 
SER N   H    sing N N 367 
SER N   H2   sing N N 368 
SER CA  C    sing N N 369 
SER CA  CB   sing N N 370 
SER CA  HA   sing N N 371 
SER C   O    doub N N 372 
SER C   OXT  sing N N 373 
SER CB  OG   sing N N 374 
SER CB  HB2  sing N N 375 
SER CB  HB3  sing N N 376 
SER OG  HG   sing N N 377 
SER OXT HXT  sing N N 378 
THR N   CA   sing N N 379 
THR N   H    sing N N 380 
THR N   H2   sing N N 381 
THR CA  C    sing N N 382 
THR CA  CB   sing N N 383 
THR CA  HA   sing N N 384 
THR C   O    doub N N 385 
THR C   OXT  sing N N 386 
THR CB  OG1  sing N N 387 
THR CB  CG2  sing N N 388 
THR CB  HB   sing N N 389 
THR OG1 HG1  sing N N 390 
THR CG2 HG21 sing N N 391 
THR CG2 HG22 sing N N 392 
THR CG2 HG23 sing N N 393 
THR OXT HXT  sing N N 394 
TRP N   CA   sing N N 395 
TRP N   H    sing N N 396 
TRP N   H2   sing N N 397 
TRP CA  C    sing N N 398 
TRP CA  CB   sing N N 399 
TRP CA  HA   sing N N 400 
TRP C   O    doub N N 401 
TRP C   OXT  sing N N 402 
TRP CB  CG   sing N N 403 
TRP CB  HB2  sing N N 404 
TRP CB  HB3  sing N N 405 
TRP CG  CD1  doub Y N 406 
TRP CG  CD2  sing Y N 407 
TRP CD1 NE1  sing Y N 408 
TRP CD1 HD1  sing N N 409 
TRP CD2 CE2  doub Y N 410 
TRP CD2 CE3  sing Y N 411 
TRP NE1 CE2  sing Y N 412 
TRP NE1 HE1  sing N N 413 
TRP CE2 CZ2  sing Y N 414 
TRP CE3 CZ3  doub Y N 415 
TRP CE3 HE3  sing N N 416 
TRP CZ2 CH2  doub Y N 417 
TRP CZ2 HZ2  sing N N 418 
TRP CZ3 CH2  sing Y N 419 
TRP CZ3 HZ3  sing N N 420 
TRP CH2 HH2  sing N N 421 
TRP OXT HXT  sing N N 422 
TYR N   CA   sing N N 423 
TYR N   H    sing N N 424 
TYR N   H2   sing N N 425 
TYR CA  C    sing N N 426 
TYR CA  CB   sing N N 427 
TYR CA  HA   sing N N 428 
TYR C   O    doub N N 429 
TYR C   OXT  sing N N 430 
TYR CB  CG   sing N N 431 
TYR CB  HB2  sing N N 432 
TYR CB  HB3  sing N N 433 
TYR CG  CD1  doub Y N 434 
TYR CG  CD2  sing Y N 435 
TYR CD1 CE1  sing Y N 436 
TYR CD1 HD1  sing N N 437 
TYR CD2 CE2  doub Y N 438 
TYR CD2 HD2  sing N N 439 
TYR CE1 CZ   doub Y N 440 
TYR CE1 HE1  sing N N 441 
TYR CE2 CZ   sing Y N 442 
TYR CE2 HE2  sing N N 443 
TYR CZ  OH   sing N N 444 
TYR OH  HH   sing N N 445 
TYR OXT HXT  sing N N 446 
VAL N   CA   sing N N 447 
VAL N   H    sing N N 448 
VAL N   H2   sing N N 449 
VAL CA  C    sing N N 450 
VAL CA  CB   sing N N 451 
VAL CA  HA   sing N N 452 
VAL C   O    doub N N 453 
VAL C   OXT  sing N N 454 
VAL CB  CG1  sing N N 455 
VAL CB  CG2  sing N N 456 
VAL CB  HB   sing N N 457 
VAL CG1 HG11 sing N N 458 
VAL CG1 HG12 sing N N 459 
VAL CG1 HG13 sing N N 460 
VAL CG2 HG21 sing N N 461 
VAL CG2 HG22 sing N N 462 
VAL CG2 HG23 sing N N 463 
VAL OXT HXT  sing N N 464 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2025-02-25 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           9M0S 
_em_admin.last_update        2025-04-23 
_em_admin.map_release_date   2025-04-23 
_em_admin.title              'Acetyl-CoA-bound SLC33A1 in a cytoplasm-facing conformation' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     NONE 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                MEGADALTONS 
_em_entity_assembly_molwt.value                0.06 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         60 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'MODEL REFINEMENT'              ? 1  ? ? ? PHENIX 1.21_5207: 
'IMAGE ACQUISITION'             ? 2  1 1 1 ?      ?          
'PARTICLE SELECTION'            ? 3  1 1 1 ?      ?          
'VOLUME SELECTION'              ? 4  1 1 1 ?      ?          
CLASSIFICATION                  ? 5  1 1 1 ?      ?          
MASKING                         ? 6  1 1 1 ?      ?          
RECONSTRUCTION                  ? 7  1 1 1 ?      ?          
'INITIAL EULER ASSIGNMENT'      ? 8  1 1 1 ?      ?          
'FINAL EULER ASSIGNMENT'        ? 9  1 1 1 ?      ?          
'CTF CORRECTION'                ? 10 1 1 1 ?      ?          
'LAYERLINE INDEXING'            ? 11 1 1 1 ?      ?          
'DIFFRACTION INDEXING'          ? 12 1 1 1 ?      ?          
'MODEL FITTING'                 ? 13 1 1 1 ?      ?          
'SERIES ALIGNMENT'              ? 14 1 1 1 ?      ?          
'MOLECULAR REPLACEMENT'         ? 15 1 1 1 ?      ?          
'LATTICE DISTORTION CORRECTION' ? 16 1 1 1 ?      ?          
'SYMMETRY DETERMINATION'        ? 17 1 1 1 ?      ?          
'CRYSTALLOGRAPHY MERGING'       ? 18 1 1 1 ?      ?          
OTHER                           ? 19 1 1 1 ?      ?          
# 
_em_specimen.concentration           10 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Ministry of Science and Technology (MoST, China)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           32471252 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    9M0S 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
P 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLU A 1 71  ? 131.974 96.510  125.185 1.00 105.52 ? 71  GLU A N   1 
ATOM   2    C CA  . GLU A 1 71  ? 131.089 97.615  125.531 1.00 105.52 ? 71  GLU A CA  1 
ATOM   3    C C   . GLU A 1 71  ? 129.640 97.286  125.188 1.00 105.52 ? 71  GLU A C   1 
ATOM   4    O O   . GLU A 1 71  ? 128.953 98.068  124.533 1.00 105.52 ? 71  GLU A O   1 
ATOM   5    C CB  . GLU A 1 71  ? 131.526 98.894  124.817 1.00 105.52 ? 71  GLU A CB  1 
ATOM   6    C CG  . GLU A 1 71  ? 132.858 99.440  125.301 1.00 105.52 ? 71  GLU A CG  1 
ATOM   7    C CD  . GLU A 1 71  ? 133.282 100.692 124.560 1.00 105.52 ? 71  GLU A CD  1 
ATOM   8    O OE1 . GLU A 1 71  ? 132.612 101.057 123.573 1.00 105.52 ? 71  GLU A OE1 1 
ATOM   9    O OE2 . GLU A 1 71  ? 134.286 101.312 124.968 1.00 105.52 ? 71  GLU A OE2 1 
ATOM   10   N N   . LEU A 1 72  ? 129.183 96.115  125.637 1.00 104.20 ? 72  LEU A N   1 
ATOM   11   C CA  . LEU A 1 72  ? 127.803 95.710  125.406 1.00 104.20 ? 72  LEU A CA  1 
ATOM   12   C C   . LEU A 1 72  ? 126.826 96.497  126.270 1.00 104.20 ? 72  LEU A C   1 
ATOM   13   O O   . LEU A 1 72  ? 125.661 96.655  125.887 1.00 104.20 ? 72  LEU A O   1 
ATOM   14   C CB  . LEU A 1 72  ? 127.658 94.206  125.660 1.00 104.20 ? 72  LEU A CB  1 
ATOM   15   C CG  . LEU A 1 72  ? 126.331 93.510  125.346 1.00 104.20 ? 72  LEU A CG  1 
ATOM   16   C CD1 . LEU A 1 72  ? 126.017 93.616  123.864 1.00 104.20 ? 72  LEU A CD1 1 
ATOM   17   C CD2 . LEU A 1 72  ? 126.362 92.056  125.786 1.00 104.20 ? 72  LEU A CD2 1 
ATOM   18   N N   . SER A 1 73  ? 127.286 97.029  127.407 1.00 103.45 ? 73  SER A N   1 
ATOM   19   C CA  . SER A 1 73  ? 126.410 97.761  128.316 1.00 103.45 ? 73  SER A CA  1 
ATOM   20   C C   . SER A 1 73  ? 125.981 99.114  127.763 1.00 103.45 ? 73  SER A C   1 
ATOM   21   O O   . SER A 1 73  ? 125.035 99.708  128.289 1.00 103.45 ? 73  SER A O   1 
ATOM   22   C CB  . SER A 1 73  ? 127.103 97.955  129.665 1.00 103.45 ? 73  SER A CB  1 
ATOM   23   O OG  . SER A 1 73  ? 128.235 98.796  129.536 1.00 103.45 ? 73  SER A OG  1 
ATOM   24   N N   . SER A 1 74  ? 126.649 99.616  126.727 1.00 100.60 ? 74  SER A N   1 
ATOM   25   C CA  . SER A 1 74  ? 126.267 100.869 126.096 1.00 100.60 ? 74  SER A CA  1 
ATOM   26   C C   . SER A 1 74  ? 125.632 100.700 124.727 1.00 100.60 ? 74  SER A C   1 
ATOM   27   O O   . SER A 1 74  ? 124.760 101.493 124.364 1.00 100.60 ? 74  SER A O   1 
ATOM   28   C CB  . SER A 1 74  ? 127.483 101.788 125.955 1.00 100.60 ? 74  SER A CB  1 
ATOM   29   O OG  . SER A 1 74  ? 127.130 102.961 125.252 1.00 100.60 ? 74  SER A OG  1 
ATOM   30   N N   . ILE A 1 75  ? 126.039 99.687  123.959 1.00 94.28  ? 75  ILE A N   1 
ATOM   31   C CA  . ILE A 1 75  ? 125.490 99.528  122.620 1.00 94.28  ? 75  ILE A CA  1 
ATOM   32   C C   . ILE A 1 75  ? 124.059 98.994  122.672 1.00 94.28  ? 75  ILE A C   1 
ATOM   33   O O   . ILE A 1 75  ? 123.264 99.287  121.775 1.00 94.28  ? 75  ILE A O   1 
ATOM   34   C CB  . ILE A 1 75  ? 126.433 98.652  121.766 1.00 94.28  ? 75  ILE A CB  1 
ATOM   35   C CG1 . ILE A 1 75  ? 126.077 98.741  120.281 1.00 94.28  ? 75  ILE A CG1 1 
ATOM   36   C CG2 . ILE A 1 75  ? 126.440 97.205  122.231 1.00 94.28  ? 75  ILE A CG2 1 
ATOM   37   C CD1 . ILE A 1 75  ? 127.141 98.187  119.366 1.00 94.28  ? 75  ILE A CD1 1 
ATOM   38   N N   . LEU A 1 76  ? 123.677 98.289  123.742 1.00 90.28  ? 76  LEU A N   1 
ATOM   39   C CA  . LEU A 1 76  ? 122.278 97.904  123.897 1.00 90.28  ? 76  LEU A CA  1 
ATOM   40   C C   . LEU A 1 76  ? 121.416 99.103  124.264 1.00 90.28  ? 76  LEU A C   1 
ATOM   41   O O   . LEU A 1 76  ? 120.269 99.209  123.816 1.00 90.28  ? 76  LEU A O   1 
ATOM   42   C CB  . LEU A 1 76  ? 122.141 96.801  124.943 1.00 90.28  ? 76  LEU A CB  1 
ATOM   43   C CG  . LEU A 1 76  ? 122.714 95.443  124.542 1.00 90.28  ? 76  LEU A CG  1 
ATOM   44   C CD1 . LEU A 1 76  ? 122.645 94.467  125.702 1.00 90.28  ? 76  LEU A CD1 1 
ATOM   45   C CD2 . LEU A 1 76  ? 121.973 94.894  123.335 1.00 90.28  ? 76  LEU A CD2 1 
ATOM   46   N N   . LEU A 1 77  ? 121.961 100.030 125.058 1.00 85.03  ? 77  LEU A N   1 
ATOM   47   C CA  . LEU A 1 77  ? 121.257 101.275 125.351 1.00 85.03  ? 77  LEU A CA  1 
ATOM   48   C C   . LEU A 1 77  ? 121.109 102.128 124.099 1.00 85.03  ? 77  LEU A C   1 
ATOM   49   O O   . LEU A 1 77  ? 120.073 102.768 123.892 1.00 85.03  ? 77  LEU A O   1 
ATOM   50   C CB  . LEU A 1 77  ? 121.998 102.052 126.436 1.00 85.03  ? 77  LEU A CB  1 
ATOM   51   C CG  . LEU A 1 77  ? 121.379 103.373 126.884 1.00 85.03  ? 77  LEU A CG  1 
ATOM   52   C CD1 . LEU A 1 77  ? 120.025 103.127 127.518 1.00 85.03  ? 77  LEU A CD1 1 
ATOM   53   C CD2 . LEU A 1 77  ? 122.308 104.085 127.846 1.00 85.03  ? 77  LEU A CD2 1 
ATOM   54   N N   . LEU A 1 78  ? 122.127 102.122 123.241 1.00 83.85  ? 78  LEU A N   1 
ATOM   55   C CA  . LEU A 1 78  ? 122.050 102.868 121.989 1.00 83.85  ? 78  LEU A CA  1 
ATOM   56   C C   . LEU A 1 78  ? 121.072 102.213 121.014 1.00 83.85  ? 78  LEU A C   1 
ATOM   57   O O   . LEU A 1 78  ? 120.358 102.909 120.279 1.00 83.85  ? 78  LEU A O   1 
ATOM   58   C CB  . LEU A 1 78  ? 123.457 102.993 121.407 1.00 83.85  ? 78  LEU A CB  1 
ATOM   59   C CG  . LEU A 1 78  ? 123.787 103.884 120.221 1.00 83.85  ? 78  LEU A CG  1 
ATOM   60   C CD1 . LEU A 1 78  ? 125.142 104.498 120.461 1.00 83.85  ? 78  LEU A CD1 1 
ATOM   61   C CD2 . LEU A 1 78  ? 123.850 103.038 118.984 1.00 83.85  ? 78  LEU A CD2 1 
ATOM   62   N N   . LEU A 1 79  ? 120.999 100.878 121.027 1.00 78.55  ? 79  LEU A N   1 
ATOM   63   C CA  . LEU A 1 79  ? 119.986 100.160 120.258 1.00 78.55  ? 79  LEU A CA  1 
ATOM   64   C C   . LEU A 1 79  ? 118.585 100.490 120.746 1.00 78.55  ? 79  LEU A C   1 
ATOM   65   O O   . LEU A 1 79  ? 117.661 100.668 119.943 1.00 78.55  ? 79  LEU A O   1 
ATOM   66   C CB  . LEU A 1 79  ? 120.230 98.656  120.359 1.00 78.55  ? 79  LEU A CB  1 
ATOM   67   C CG  . LEU A 1 79  ? 119.270 97.759  119.583 1.00 78.55  ? 79  LEU A CG  1 
ATOM   68   C CD1 . LEU A 1 79  ? 119.406 98.032  118.108 1.00 78.55  ? 79  LEU A CD1 1 
ATOM   69   C CD2 . LEU A 1 79  ? 119.526 96.294  119.886 1.00 78.55  ? 79  LEU A CD2 1 
ATOM   70   N N   . PHE A 1 80  ? 118.415 100.584 122.062 1.00 77.62  ? 80  PHE A N   1 
ATOM   71   C CA  . PHE A 1 80  ? 117.113 100.911 122.624 1.00 77.62  ? 80  PHE A CA  1 
ATOM   72   C C   . PHE A 1 80  ? 116.734 102.352 122.313 1.00 77.62  ? 80  PHE A C   1 
ATOM   73   O O   . PHE A 1 80  ? 115.566 102.645 122.038 1.00 77.62  ? 80  PHE A O   1 
ATOM   74   C CB  . PHE A 1 80  ? 117.135 100.646 124.126 1.00 77.62  ? 80  PHE A CB  1 
ATOM   75   C CG  . PHE A 1 80  ? 115.797 100.730 124.783 1.00 77.62  ? 80  PHE A CG  1 
ATOM   76   C CD1 . PHE A 1 80  ? 114.843 99.754  124.557 1.00 77.62  ? 80  PHE A CD1 1 
ATOM   77   C CD2 . PHE A 1 80  ? 115.510 101.751 125.670 1.00 77.62  ? 80  PHE A CD2 1 
ATOM   78   C CE1 . PHE A 1 80  ? 113.612 99.814  125.176 1.00 77.62  ? 80  PHE A CE1 1 
ATOM   79   C CE2 . PHE A 1 80  ? 114.285 101.812 126.297 1.00 77.62  ? 80  PHE A CE2 1 
ATOM   80   C CZ  . PHE A 1 80  ? 113.335 100.841 126.053 1.00 77.62  ? 80  PHE A CZ  1 
ATOM   81   N N   . LEU A 1 81  ? 117.716 103.258 122.293 1.00 76.77  ? 81  LEU A N   1 
ATOM   82   C CA  . LEU A 1 81  ? 117.424 104.636 121.910 1.00 76.77  ? 81  LEU A CA  1 
ATOM   83   C C   . LEU A 1 81  ? 117.118 104.762 120.424 1.00 76.77  ? 81  LEU A C   1 
ATOM   84   O O   . LEU A 1 81  ? 116.341 105.636 120.037 1.00 76.77  ? 81  LEU A O   1 
ATOM   85   C CB  . LEU A 1 81  ? 118.571 105.562 122.305 1.00 76.77  ? 81  LEU A CB  1 
ATOM   86   C CG  . LEU A 1 81  ? 118.656 105.802 123.811 1.00 76.77  ? 81  LEU A CG  1 
ATOM   87   C CD1 . LEU A 1 81  ? 119.874 106.623 124.163 1.00 76.77  ? 81  LEU A CD1 1 
ATOM   88   C CD2 . LEU A 1 81  ? 117.394 106.488 124.298 1.00 76.77  ? 81  LEU A CD2 1 
ATOM   89   N N   . TYR A 1 82  ? 117.654 103.883 119.575 1.00 75.36  ? 82  TYR A N   1 
ATOM   90   C CA  . TYR A 1 82  ? 117.203 103.934 118.185 1.00 75.36  ? 82  TYR A CA  1 
ATOM   91   C C   . TYR A 1 82  ? 115.876 103.221 117.946 1.00 75.36  ? 82  TYR A C   1 
ATOM   92   O O   . TYR A 1 82  ? 115.168 103.574 116.997 1.00 75.36  ? 82  TYR A O   1 
ATOM   93   C CB  . TYR A 1 82  ? 118.259 103.395 117.226 1.00 75.36  ? 82  TYR A CB  1 
ATOM   94   C CG  . TYR A 1 82  ? 119.349 104.396 116.954 1.00 75.36  ? 82  TYR A CG  1 
ATOM   95   C CD1 . TYR A 1 82  ? 119.069 105.564 116.262 1.00 75.36  ? 82  TYR A CD1 1 
ATOM   96   C CD2 . TYR A 1 82  ? 120.658 104.155 117.332 1.00 75.36  ? 82  TYR A CD2 1 
ATOM   97   C CE1 . TYR A 1 82  ? 120.050 106.489 116.007 1.00 75.36  ? 82  TYR A CE1 1 
ATOM   98   C CE2 . TYR A 1 82  ? 121.646 105.068 117.063 1.00 75.36  ? 82  TYR A CE2 1 
ATOM   99   C CZ  . TYR A 1 82  ? 121.340 106.225 116.392 1.00 75.36  ? 82  TYR A CZ  1 
ATOM   100  O OH  . TYR A 1 82  ? 122.336 107.131 116.138 1.00 75.36  ? 82  TYR A OH  1 
ATOM   101  N N   . VAL A 1 83  ? 115.497 102.257 118.785 1.00 70.03  ? 83  VAL A N   1 
ATOM   102  C CA  . VAL A 1 83  ? 114.129 101.742 118.721 1.00 70.03  ? 83  VAL A CA  1 
ATOM   103  C C   . VAL A 1 83  ? 113.139 102.823 119.152 1.00 70.03  ? 83  VAL A C   1 
ATOM   104  O O   . VAL A 1 83  ? 112.088 103.022 118.521 1.00 70.03  ? 83  VAL A O   1 
ATOM   105  C CB  . VAL A 1 83  ? 113.997 100.462 119.567 1.00 70.03  ? 83  VAL A CB  1 
ATOM   106  C CG1 . VAL A 1 83  ? 112.556 100.023 119.670 1.00 70.03  ? 83  VAL A CG1 1 
ATOM   107  C CG2 . VAL A 1 83  ? 114.811 99.347  118.949 1.00 70.03  ? 83  VAL A CG2 1 
ATOM   108  N N   . LEU A 1 84  ? 113.486 103.579 120.192 1.00 68.88  ? 84  LEU A N   1 
ATOM   109  C CA  . LEU A 1 84  ? 112.660 104.714 120.584 1.00 68.88  ? 84  LEU A CA  1 
ATOM   110  C C   . LEU A 1 84  ? 112.774 105.870 119.597 1.00 68.88  ? 84  LEU A C   1 
ATOM   111  O O   . LEU A 1 84  ? 111.926 106.758 119.605 1.00 68.88  ? 84  LEU A O   1 
ATOM   112  C CB  . LEU A 1 84  ? 113.024 105.184 121.995 1.00 68.88  ? 84  LEU A CB  1 
ATOM   113  C CG  . LEU A 1 84  ? 112.368 104.529 123.223 1.00 68.88  ? 84  LEU A CG  1 
ATOM   114  C CD1 . LEU A 1 84  ? 110.889 104.744 123.224 1.00 68.88  ? 84  LEU A CD1 1 
ATOM   115  C CD2 . LEU A 1 84  ? 112.631 103.054 123.351 1.00 68.88  ? 84  LEU A CD2 1 
ATOM   116  N N   . GLN A 1 85  ? 113.813 105.894 118.767 1.00 71.35  ? 85  GLN A N   1 
ATOM   117  C CA  . GLN A 1 85  ? 113.813 106.779 117.609 1.00 71.35  ? 85  GLN A CA  1 
ATOM   118  C C   . GLN A 1 85  ? 112.793 106.330 116.575 1.00 71.35  ? 85  GLN A C   1 
ATOM   119  O O   . GLN A 1 85  ? 112.078 107.154 115.995 1.00 71.35  ? 85  GLN A O   1 
ATOM   120  C CB  . GLN A 1 85  ? 115.207 106.825 116.988 1.00 71.35  ? 85  GLN A CB  1 
ATOM   121  C CG  . GLN A 1 85  ? 115.274 107.585 115.696 1.00 71.35  ? 85  GLN A CG  1 
ATOM   122  C CD  . GLN A 1 85  ? 114.953 109.020 115.911 1.00 71.35  ? 85  GLN A CD  1 
ATOM   123  O OE1 . GLN A 1 85  ? 115.432 109.616 116.864 1.00 71.35  ? 85  GLN A OE1 1 
ATOM   124  N NE2 . GLN A 1 85  ? 114.121 109.589 115.049 1.00 71.35  ? 85  GLN A NE2 1 
ATOM   125  N N   . GLY A 1 86  ? 112.717 105.023 116.328 1.00 68.74  ? 86  GLY A N   1 
ATOM   126  C CA  . GLY A 1 86  ? 111.826 104.511 115.304 1.00 68.74  ? 86  GLY A CA  1 
ATOM   127  C C   . GLY A 1 86  ? 110.359 104.491 115.673 1.00 68.74  ? 86  GLY A C   1 
ATOM   128  O O   . GLY A 1 86  ? 109.520 104.357 114.778 1.00 68.74  ? 86  GLY A O   1 
ATOM   129  N N   . ILE A 1 87  ? 110.032 104.570 116.968 1.00 64.94  ? 87  ILE A N   1 
ATOM   130  C CA  . ILE A 1 87  ? 108.617 104.600 117.377 1.00 64.94  ? 87  ILE A CA  1 
ATOM   131  C C   . ILE A 1 87  ? 107.855 105.820 116.851 1.00 64.94  ? 87  ILE A C   1 
ATOM   132  O O   . ILE A 1 87  ? 106.748 105.638 116.313 1.00 64.94  ? 87  ILE A O   1 
ATOM   133  C CB  . ILE A 1 87  ? 108.499 104.411 118.902 1.00 64.94  ? 87  ILE A CB  1 
ATOM   134  C CG1 . ILE A 1 87  ? 108.903 103.001 119.308 1.00 64.94  ? 87  ILE A CG1 1 
ATOM   135  C CG2 . ILE A 1 87  ? 107.093 104.706 119.395 1.00 64.94  ? 87  ILE A CG2 1 
ATOM   136  C CD1 . ILE A 1 87  ? 108.005 101.951 118.742 1.00 64.94  ? 87  ILE A CD1 1 
ATOM   137  N N   . PRO A 1 88  ? 108.373 107.071 116.936 1.00 65.42  ? 88  PRO A N   1 
ATOM   138  C CA  . PRO A 1 88  ? 107.653 108.169 116.264 1.00 65.42  ? 88  PRO A CA  1 
ATOM   139  C C   . PRO A 1 88  ? 107.594 108.062 114.754 1.00 65.42  ? 88  PRO A C   1 
ATOM   140  O O   . PRO A 1 88  ? 106.583 108.452 114.164 1.00 65.42  ? 88  PRO A O   1 
ATOM   141  C CB  . PRO A 1 88  ? 108.440 109.412 116.686 1.00 65.42  ? 88  PRO A CB  1 
ATOM   142  C CG  . PRO A 1 88  ? 109.017 109.067 117.941 1.00 65.42  ? 88  PRO A CG  1 
ATOM   143  C CD  . PRO A 1 88  ? 109.419 107.651 117.800 1.00 65.42  ? 88  PRO A CD  1 
ATOM   144  N N   . LEU A 1 89  ? 108.643 107.554 114.110 1.00 65.69  ? 89  LEU A N   1 
ATOM   145  C CA  . LEU A 1 89  ? 108.591 107.351 112.667 1.00 65.69  ? 89  LEU A CA  1 
ATOM   146  C C   . LEU A 1 89  ? 107.584 106.279 112.286 1.00 65.69  ? 89  LEU A C   1 
ATOM   147  O O   . LEU A 1 89  ? 106.865 106.428 111.292 1.00 65.69  ? 89  LEU A O   1 
ATOM   148  C CB  . LEU A 1 89  ? 109.980 107.016 112.144 1.00 65.69  ? 89  LEU A CB  1 
ATOM   149  C CG  . LEU A 1 89  ? 110.729 108.317 111.926 1.00 65.69  ? 89  LEU A CG  1 
ATOM   150  C CD1 . LEU A 1 89  ? 112.205 108.118 111.811 1.00 65.69  ? 89  LEU A CD1 1 
ATOM   151  C CD2 . LEU A 1 89  ? 110.190 108.853 110.618 1.00 65.69  ? 89  LEU A CD2 1 
ATOM   152  N N   . GLY A 1 90  ? 107.488 105.217 113.085 1.00 65.22  ? 90  GLY A N   1 
ATOM   153  C CA  . GLY A 1 90  ? 106.496 104.189 112.818 1.00 65.22  ? 90  GLY A CA  1 
ATOM   154  C C   . GLY A 1 90  ? 105.076 104.685 113.003 1.00 65.22  ? 90  GLY A C   1 
ATOM   155  O O   . GLY A 1 90  ? 104.190 104.364 112.205 1.00 65.22  ? 90  GLY A O   1 
ATOM   156  N N   . LEU A 1 91  ? 104.845 105.502 114.032 1.00 62.26  ? 91  LEU A N   1 
ATOM   157  C CA  . LEU A 1 91  ? 103.522 106.092 114.209 1.00 62.26  ? 91  LEU A CA  1 
ATOM   158  C C   . LEU A 1 91  ? 103.198 107.089 113.103 1.00 62.26  ? 91  LEU A C   1 
ATOM   159  O O   . LEU A 1 91  ? 102.073 107.101 112.588 1.00 62.26  ? 91  LEU A O   1 
ATOM   160  C CB  . LEU A 1 91  ? 103.426 106.746 115.581 1.00 62.26  ? 91  LEU A CB  1 
ATOM   161  C CG  . LEU A 1 91  ? 103.332 105.690 116.671 1.00 62.26  ? 91  LEU A CG  1 
ATOM   162  C CD1 . LEU A 1 91  ? 103.491 106.305 118.029 1.00 62.26  ? 91  LEU A CD1 1 
ATOM   163  C CD2 . LEU A 1 91  ? 101.983 105.032 116.551 1.00 62.26  ? 91  LEU A CD2 1 
ATOM   164  N N   . ALA A 1 92  ? 104.174 107.906 112.702 1.00 60.63  ? 92  ALA A N   1 
ATOM   165  C CA  . ALA A 1 92  ? 103.945 108.891 111.653 1.00 60.63  ? 92  ALA A CA  1 
ATOM   166  C C   . ALA A 1 92  ? 103.735 108.235 110.298 1.00 60.63  ? 92  ALA A C   1 
ATOM   167  O O   . ALA A 1 92  ? 103.072 108.813 109.435 1.00 60.63  ? 92  ALA A O   1 
ATOM   168  C CB  . ALA A 1 92  ? 105.113 109.869 111.591 1.00 60.63  ? 92  ALA A CB  1 
ATOM   169  N N   . GLY A 1 93  ? 104.289 107.040 110.087 1.00 60.15  ? 93  GLY A N   1 
ATOM   170  C CA  . GLY A 1 93  ? 103.945 106.277 108.903 1.00 60.15  ? 93  GLY A CA  1 
ATOM   171  C C   . GLY A 1 93  ? 102.649 105.509 109.021 1.00 60.15  ? 93  GLY A C   1 
ATOM   172  O O   . GLY A 1 93  ? 102.057 105.152 108.000 1.00 60.15  ? 93  GLY A O   1 
ATOM   173  N N   . SER A 1 94  ? 102.199 105.241 110.247 1.00 60.26  ? 94  SER A N   1 
ATOM   174  C CA  . SER A 1 94  ? 100.928 104.554 110.439 1.00 60.26  ? 94  SER A CA  1 
ATOM   175  C C   . SER A 1 94  ? 99.724  105.470 110.283 1.00 60.26  ? 94  SER A C   1 
ATOM   176  O O   . SER A 1 94  ? 98.644  104.993 109.921 1.00 60.26  ? 94  SER A O   1 
ATOM   177  C CB  . SER A 1 94  ? 100.884 103.913 111.820 1.00 60.26  ? 94  SER A CB  1 
ATOM   178  O OG  . SER A 1 94  ? 99.589  103.419 112.081 1.00 60.26  ? 94  SER A OG  1 
ATOM   179  N N   . ILE A 1 95  ? 99.877  106.761 110.593 1.00 57.95  ? 95  ILE A N   1 
ATOM   180  C CA  . ILE A 1 95  ? 98.728  107.685 110.534 1.00 57.95  ? 95  ILE A CA  1 
ATOM   181  C C   . ILE A 1 95  ? 98.112  107.868 109.146 1.00 57.95  ? 95  ILE A C   1 
ATOM   182  O O   . ILE A 1 95  ? 96.877  107.949 109.069 1.00 57.95  ? 95  ILE A O   1 
ATOM   183  C CB  . ILE A 1 95  ? 99.081  109.011 111.222 1.00 57.95  ? 95  ILE A CB  1 
ATOM   184  C CG1 . ILE A 1 95  ? 99.385  108.762 112.687 1.00 57.95  ? 95  ILE A CG1 1 
ATOM   185  C CG2 . ILE A 1 95  ? 97.927  110.004 111.220 1.00 57.95  ? 95  ILE A CG2 1 
ATOM   186  C CD1 . ILE A 1 95  ? 98.265  108.108 113.435 1.00 57.95  ? 95  ILE A CD1 1 
ATOM   187  N N   . PRO A 1 96  ? 98.861  107.944 108.021 1.00 61.00  ? 96  PRO A N   1 
ATOM   188  C CA  . PRO A 1 96  ? 98.168  108.009 106.714 1.00 61.00  ? 96  PRO A CA  1 
ATOM   189  C C   . PRO A 1 96  ? 97.291  106.812 106.395 1.00 61.00  ? 96  PRO A C   1 
ATOM   190  O O   . PRO A 1 96  ? 96.216  106.988 105.807 1.00 61.00  ? 96  PRO A O   1 
ATOM   191  C CB  . PRO A 1 96  ? 99.321  108.122 105.711 1.00 61.00  ? 96  PRO A CB  1 
ATOM   192  C CG  . PRO A 1 96  ? 100.360 108.790 106.438 1.00 61.00  ? 96  PRO A CG  1 
ATOM   193  C CD  . PRO A 1 96  ? 100.293 108.250 107.825 1.00 61.00  ? 96  PRO A CD  1 
ATOM   194  N N   . LEU A 1 97  ? 97.689  105.616 106.826 1.00 61.63  ? 97  LEU A N   1 
ATOM   195  C CA  . LEU A 1 97  ? 96.861  104.432 106.627 1.00 61.63  ? 97  LEU A CA  1 
ATOM   196  C C   . LEU A 1 97  ? 95.579  104.517 107.452 1.00 61.63  ? 97  LEU A C   1 
ATOM   197  O O   . LEU A 1 97  ? 94.498  104.147 106.974 1.00 61.63  ? 97  LEU A O   1 
ATOM   198  C CB  . LEU A 1 97  ? 97.654  103.177 106.994 1.00 61.63  ? 97  LEU A CB  1 
ATOM   199  C CG  . LEU A 1 97  ? 98.731  102.571 106.078 1.00 61.63  ? 97  LEU A CG  1 
ATOM   200  C CD1 . LEU A 1 97  ? 98.186  102.249 104.713 1.00 61.63  ? 97  LEU A CD1 1 
ATOM   201  C CD2 . LEU A 1 97  ? 100.006 103.401 105.966 1.00 61.63  ? 97  LEU A CD2 1 
ATOM   202  N N   . ILE A 1 98  ? 95.677  105.041 108.679 1.00 63.14  ? 98  ILE A N   1 
ATOM   203  C CA  . ILE A 1 98  ? 94.507  105.182 109.544 1.00 63.14  ? 98  ILE A CA  1 
ATOM   204  C C   . ILE A 1 98  ? 93.565  106.245 108.999 1.00 63.14  ? 98  ILE A C   1 
ATOM   205  O O   . ILE A 1 98  ? 92.346  106.042 108.937 1.00 63.14  ? 98  ILE A O   1 
ATOM   206  C CB  . ILE A 1 98  ? 94.940  105.510 110.984 1.00 63.14  ? 98  ILE A CB  1 
ATOM   207  C CG1 . ILE A 1 98  ? 95.753  104.370 111.572 1.00 63.14  ? 98  ILE A CG1 1 
ATOM   208  C CG2 . ILE A 1 98  ? 93.741  105.769 111.873 1.00 63.14  ? 98  ILE A CG2 1 
ATOM   209  C CD1 . ILE A 1 98  ? 96.382  104.733 112.871 1.00 63.14  ? 98  ILE A CD1 1 
ATOM   210  N N   . LEU A 1 99  ? 94.117  107.394 108.596 1.00 63.28  ? 99  LEU A N   1 
ATOM   211  C CA  . LEU A 1 99  ? 93.302  108.475 108.057 1.00 63.28  ? 99  LEU A CA  1 
ATOM   212  C C   . LEU A 1 99  ? 92.643  108.084 106.746 1.00 63.28  ? 99  LEU A C   1 
ATOM   213  O O   . LEU A 1 99  ? 91.519  108.516 106.473 1.00 63.28  ? 99  LEU A O   1 
ATOM   214  C CB  . LEU A 1 99  ? 94.139  109.737 107.861 1.00 63.28  ? 99  LEU A CB  1 
ATOM   215  C CG  . LEU A 1 99  ? 94.643  110.457 109.107 1.00 63.28  ? 99  LEU A CG  1 
ATOM   216  C CD1 . LEU A 1 99  ? 95.529  111.614 108.708 1.00 63.28  ? 99  LEU A CD1 1 
ATOM   217  C CD2 . LEU A 1 99  ? 93.484  110.940 109.945 1.00 63.28  ? 99  LEU A CD2 1 
ATOM   218  N N   . GLN A 1 100 ? 93.297  107.249 105.938 1.00 65.46  ? 100 GLN A N   1 
ATOM   219  C CA  . GLN A 1 100 ? 92.623  106.784 104.738 1.00 65.46  ? 100 GLN A CA  1 
ATOM   220  C C   . GLN A 1 100 ? 91.593  105.712 105.065 1.00 65.46  ? 100 GLN A C   1 
ATOM   221  O O   . GLN A 1 100 ? 90.594  105.578 104.351 1.00 65.46  ? 100 GLN A O   1 
ATOM   222  C CB  . GLN A 1 100 ? 93.638  106.279 103.716 1.00 65.46  ? 100 GLN A CB  1 
ATOM   223  C CG  . GLN A 1 100 ? 93.034  106.096 102.352 1.00 65.46  ? 100 GLN A CG  1 
ATOM   224  C CD  . GLN A 1 100 ? 92.353  107.363 101.890 1.00 65.46  ? 100 GLN A CD  1 
ATOM   225  O OE1 . GLN A 1 100 ? 91.128  107.469 101.907 1.00 65.46  ? 100 GLN A OE1 1 
ATOM   226  N NE2 . GLN A 1 100 ? 93.146  108.346 101.504 1.00 65.46  ? 100 GLN A NE2 1 
ATOM   227  N N   . SER A 1 101 ? 91.788  104.974 106.161 1.00 66.24  ? 101 SER A N   1 
ATOM   228  C CA  . SER A 1 101 ? 90.732  104.085 106.629 1.00 66.24  ? 101 SER A CA  1 
ATOM   229  C C   . SER A 1 101 ? 89.533  104.852 107.176 1.00 66.24  ? 101 SER A C   1 
ATOM   230  O O   . SER A 1 101 ? 88.431  104.297 107.221 1.00 66.24  ? 101 SER A O   1 
ATOM   231  C CB  . SER A 1 101 ? 91.275  103.133 107.694 1.00 66.24  ? 101 SER A CB  1 
ATOM   232  O OG  . SER A 1 101 ? 90.261  102.266 108.167 1.00 66.24  ? 101 SER A OG  1 
ATOM   233  N N   . LYS A 1 102 ? 89.717  106.109 107.580 1.00 70.77  ? 102 LYS A N   1 
ATOM   234  C CA  . LYS A 1 102 ? 88.625  106.962 108.029 1.00 70.77  ? 102 LYS A CA  1 
ATOM   235  C C   . LYS A 1 102 ? 87.987  107.758 106.896 1.00 70.77  ? 102 LYS A C   1 
ATOM   236  O O   . LYS A 1 102 ? 87.140  108.616 107.172 1.00 70.77  ? 102 LYS A O   1 
ATOM   237  C CB  . LYS A 1 102 ? 89.113  107.923 109.115 1.00 70.77  ? 102 LYS A CB  1 
ATOM   238  C CG  . LYS A 1 102 ? 89.602  107.244 110.377 1.00 70.77  ? 102 LYS A CG  1 
ATOM   239  C CD  . LYS A 1 102 ? 88.463  106.570 111.107 1.00 70.77  ? 102 LYS A CD  1 
ATOM   240  C CE  . LYS A 1 102 ? 88.920  106.014 112.438 1.00 70.77  ? 102 LYS A CE  1 
ATOM   241  N NZ  . LYS A 1 102 ? 89.836  104.859 112.252 1.00 70.77  ? 102 LYS A NZ  1 
ATOM   242  N N   . ASN A 1 103 ? 88.388  107.495 105.645 1.00 71.56  ? 103 ASN A N   1 
ATOM   243  C CA  . ASN A 1 103 ? 87.840  108.108 104.427 1.00 71.56  ? 103 ASN A CA  1 
ATOM   244  C C   . ASN A 1 103 ? 87.974  109.634 104.442 1.00 71.56  ? 103 ASN A C   1 
ATOM   245  O O   . ASN A 1 103 ? 86.989  110.373 104.465 1.00 71.56  ? 103 ASN A O   1 
ATOM   246  C CB  . ASN A 1 103 ? 86.383  107.687 104.195 1.00 71.56  ? 103 ASN A CB  1 
ATOM   247  C CG  . ASN A 1 103 ? 86.253  106.235 103.783 1.00 71.56  ? 103 ASN A CG  1 
ATOM   248  O OD1 . ASN A 1 103 ? 87.029  105.738 102.968 1.00 71.56  ? 103 ASN A OD1 1 
ATOM   249  N ND2 . ASN A 1 103 ? 85.266  105.547 104.344 1.00 71.56  ? 103 ASN A ND2 1 
ATOM   250  N N   . VAL A 1 104 ? 89.220  110.095 104.433 1.00 65.39  ? 104 VAL A N   1 
ATOM   251  C CA  . VAL A 1 104 ? 89.517  111.519 104.355 1.00 65.39  ? 104 VAL A CA  1 
ATOM   252  C C   . VAL A 1 104 ? 89.976  111.824 102.933 1.00 65.39  ? 104 VAL A C   1 
ATOM   253  O O   . VAL A 1 104 ? 90.466  110.945 102.214 1.00 65.39  ? 104 VAL A O   1 
ATOM   254  C CB  . VAL A 1 104 ? 90.568  111.931 105.415 1.00 65.39  ? 104 VAL A CB  1 
ATOM   255  C CG1 . VAL A 1 104 ? 91.964  111.459 105.040 1.00 65.39  ? 104 VAL A CG1 1 
ATOM   256  C CG2 . VAL A 1 104 ? 90.532  113.427 105.698 1.00 65.39  ? 104 VAL A CG2 1 
ATOM   257  N N   . SER A 1 105 ? 89.768  113.066 102.497 1.00 64.40  ? 105 SER A N   1 
ATOM   258  C CA  . SER A 1 105 ? 90.193  113.474 101.168 1.00 64.40  ? 105 SER A CA  1 
ATOM   259  C C   . SER A 1 105 ? 91.710  113.631 101.118 1.00 64.40  ? 105 SER A C   1 
ATOM   260  O O   . SER A 1 105 ? 92.401  113.632 102.140 1.00 64.40  ? 105 SER A O   1 
ATOM   261  C CB  . SER A 1 105 ? 89.510  114.778 100.757 1.00 64.40  ? 105 SER A CB  1 
ATOM   262  O OG  . SER A 1 105 ? 88.113  114.599 100.605 1.00 64.40  ? 105 SER A OG  1 
ATOM   263  N N   . TYR A 1 106 ? 92.229  113.777 99.905  1.00 59.75  ? 106 TYR A N   1 
ATOM   264  C CA  . TYR A 1 106 ? 93.667  113.776 99.695  1.00 59.75  ? 106 TYR A CA  1 
ATOM   265  C C   . TYR A 1 106 ? 94.310  115.150 99.809  1.00 59.75  ? 106 TYR A C   1 
ATOM   266  O O   . TYR A 1 106 ? 95.535  115.222 99.923  1.00 59.75  ? 106 TYR A O   1 
ATOM   267  C CB  . TYR A 1 106 ? 93.993  113.157 98.340  1.00 59.75  ? 106 TYR A CB  1 
ATOM   268  C CG  . TYR A 1 106 ? 93.815  111.666 98.342  1.00 59.75  ? 106 TYR A CG  1 
ATOM   269  C CD1 . TYR A 1 106 ? 94.828  110.838 98.791  1.00 59.75  ? 106 TYR A CD1 1 
ATOM   270  C CD2 . TYR A 1 106 ? 92.624  111.087 97.935  1.00 59.75  ? 106 TYR A CD2 1 
ATOM   271  C CE1 . TYR A 1 106 ? 94.675  109.477 98.809  1.00 59.75  ? 106 TYR A CE1 1 
ATOM   272  C CE2 . TYR A 1 106 ? 92.460  109.723 97.949  1.00 59.75  ? 106 TYR A CE2 1 
ATOM   273  C CZ  . TYR A 1 106 ? 93.490  108.926 98.386  1.00 59.75  ? 106 TYR A CZ  1 
ATOM   274  O OH  . TYR A 1 106 ? 93.333  107.566 98.413  1.00 59.75  ? 106 TYR A OH  1 
ATOM   275  N N   . THR A 1 107 ? 93.538  116.236 99.787  1.00 60.74  ? 107 THR A N   1 
ATOM   276  C CA  . THR A 1 107 ? 94.118  117.530 100.131 1.00 60.74  ? 107 THR A CA  1 
ATOM   277  C C   . THR A 1 107 ? 94.467  117.582 101.612 1.00 60.74  ? 107 THR A C   1 
ATOM   278  O O   . THR A 1 107 ? 95.528  118.095 101.992 1.00 60.74  ? 107 THR A O   1 
ATOM   279  C CB  . THR A 1 107 ? 93.162  118.661 99.757  1.00 60.74  ? 107 THR A CB  1 
ATOM   280  O OG1 . THR A 1 107 ? 91.931  118.504 100.471 1.00 60.74  ? 107 THR A OG1 1 
ATOM   281  C CG2 . THR A 1 107 ? 92.885  118.650 98.264  1.00 60.74  ? 107 THR A CG2 1 
ATOM   282  N N   . ASP A 1 108 ? 93.600  117.014 102.456 1.00 63.49  ? 108 ASP A N   1 
ATOM   283  C CA  . ASP A 1 108 ? 93.918  116.838 103.869 1.00 63.49  ? 108 ASP A CA  1 
ATOM   284  C C   . ASP A 1 108 ? 95.091  115.887 104.065 1.00 63.49  ? 108 ASP A C   1 
ATOM   285  O O   . ASP A 1 108 ? 95.914  116.088 104.965 1.00 63.49  ? 108 ASP A O   1 
ATOM   286  C CB  . ASP A 1 108 ? 92.691  116.318 104.614 1.00 63.49  ? 108 ASP A CB  1 
ATOM   287  C CG  . ASP A 1 108 ? 91.608  117.367 104.758 1.00 63.49  ? 108 ASP A CG  1 
ATOM   288  O OD1 . ASP A 1 108 ? 91.948  118.568 104.814 1.00 63.49  ? 108 ASP A OD1 1 
ATOM   289  O OD2 . ASP A 1 108 ? 90.418  116.990 104.818 1.00 63.49  ? 108 ASP A OD2 1 
ATOM   290  N N   . GLN A 1 109 ? 95.204  114.873 103.207 1.00 58.64  ? 109 GLN A N   1 
ATOM   291  C CA  . GLN A 1 109 ? 96.318  113.938 103.295 1.00 58.64  ? 109 GLN A CA  1 
ATOM   292  C C   . GLN A 1 109 ? 97.637  114.600 102.913 1.00 58.64  ? 109 GLN A C   1 
ATOM   293  O O   . GLN A 1 109 ? 98.666  114.373 103.560 1.00 58.64  ? 109 GLN A O   1 
ATOM   294  C CB  . GLN A 1 109 ? 96.045  112.736 102.403 1.00 58.64  ? 109 GLN A CB  1 
ATOM   295  C CG  . GLN A 1 109 ? 97.117  111.716 102.484 1.00 58.64  ? 109 GLN A CG  1 
ATOM   296  C CD  . GLN A 1 109 ? 97.196  111.120 103.855 1.00 58.64  ? 109 GLN A CD  1 
ATOM   297  O OE1 . GLN A 1 109 ? 96.180  110.769 104.452 1.00 58.64  ? 109 GLN A OE1 1 
ATOM   298  N NE2 . GLN A 1 109 ? 98.404  111.025 104.382 1.00 58.64  ? 109 GLN A NE2 1 
ATOM   299  N N   . ALA A 1 110 ? 97.624  115.430 101.872 1.00 56.66  ? 110 ALA A N   1 
ATOM   300  C CA  . ALA A 1 110 ? 98.826  116.156 101.490 1.00 56.66  ? 110 ALA A CA  1 
ATOM   301  C C   . ALA A 1 110 ? 99.199  117.199 102.522 1.00 56.66  ? 110 ALA A C   1 
ATOM   302  O O   . ALA A 1 110 ? 100.386 117.481 102.706 1.00 56.66  ? 110 ALA A O   1 
ATOM   303  C CB  . ALA A 1 110 ? 98.635  116.831 100.144 1.00 56.66  ? 110 ALA A CB  1 
ATOM   304  N N   . PHE A 1 111 ? 98.209  117.794 103.189 1.00 58.84  ? 111 PHE A N   1 
ATOM   305  C CA  . PHE A 1 111 ? 98.544  118.684 104.290 1.00 58.84  ? 111 PHE A CA  1 
ATOM   306  C C   . PHE A 1 111 ? 99.107  117.910 105.470 1.00 58.84  ? 111 PHE A C   1 
ATOM   307  O O   . PHE A 1 111 ? 99.930  118.447 106.214 1.00 58.84  ? 111 PHE A O   1 
ATOM   308  C CB  . PHE A 1 111 ? 97.332  119.503 104.722 1.00 58.84  ? 111 PHE A CB  1 
ATOM   309  C CG  . PHE A 1 111 ? 97.648  120.515 105.778 1.00 58.84  ? 111 PHE A CG  1 
ATOM   310  C CD1 . PHE A 1 111 ? 98.345  121.667 105.458 1.00 58.84  ? 111 PHE A CD1 1 
ATOM   311  C CD2 . PHE A 1 111 ? 97.266  120.310 107.092 1.00 58.84  ? 111 PHE A CD2 1 
ATOM   312  C CE1 . PHE A 1 111 ? 98.649  122.603 106.426 1.00 58.84  ? 111 PHE A CE1 1 
ATOM   313  C CE2 . PHE A 1 111 ? 97.565  121.240 108.066 1.00 58.84  ? 111 PHE A CE2 1 
ATOM   314  C CZ  . PHE A 1 111 ? 98.257  122.388 107.733 1.00 58.84  ? 111 PHE A CZ  1 
ATOM   315  N N   . PHE A 1 112 ? 98.699  116.651 105.650 1.00 55.75  ? 112 PHE A N   1 
ATOM   316  C CA  . PHE A 1 112 ? 99.341  115.835 106.676 1.00 55.75  ? 112 PHE A CA  1 
ATOM   317  C C   . PHE A 1 112 ? 100.756 115.436 106.284 1.00 55.75  ? 112 PHE A C   1 
ATOM   318  O O   . PHE A 1 112 ? 101.620 115.304 107.156 1.00 55.75  ? 112 PHE A O   1 
ATOM   319  C CB  . PHE A 1 112 ? 98.529  114.578 106.985 1.00 55.75  ? 112 PHE A CB  1 
ATOM   320  C CG  . PHE A 1 112 ? 99.182  113.696 108.006 1.00 55.75  ? 112 PHE A CG  1 
ATOM   321  C CD1 . PHE A 1 112 ? 99.210  114.069 109.334 1.00 55.75  ? 112 PHE A CD1 1 
ATOM   322  C CD2 . PHE A 1 112 ? 99.806  112.521 107.634 1.00 55.75  ? 112 PHE A CD2 1 
ATOM   323  C CE1 . PHE A 1 112 ? 99.830  113.279 110.270 1.00 55.75  ? 112 PHE A CE1 1 
ATOM   324  C CE2 . PHE A 1 112 ? 100.431 111.736 108.568 1.00 55.75  ? 112 PHE A CE2 1 
ATOM   325  C CZ  . PHE A 1 112 ? 100.445 112.116 109.881 1.00 55.75  ? 112 PHE A CZ  1 
ATOM   326  N N   . SER A 1 113 ? 101.027 115.271 104.988 1.00 56.48  ? 113 SER A N   1 
ATOM   327  C CA  . SER A 1 113 ? 102.299 114.709 104.528 1.00 56.48  ? 113 SER A CA  1 
ATOM   328  C C   . SER A 1 113 ? 103.518 115.601 104.783 1.00 56.48  ? 113 SER A C   1 
ATOM   329  O O   . SER A 1 113 ? 104.620 115.215 104.386 1.00 56.48  ? 113 SER A O   1 
ATOM   330  C CB  . SER A 1 113 ? 102.220 114.387 103.038 1.00 56.48  ? 113 SER A CB  1 
ATOM   331  O OG  . SER A 1 113 ? 103.450 113.863 102.575 1.00 56.48  ? 113 SER A OG  1 
ATOM   332  N N   . PHE A 1 114 ? 103.365 116.764 105.424 1.00 55.88  ? 114 PHE A N   1 
ATOM   333  C CA  . PHE A 1 114 ? 104.496 117.541 105.913 1.00 55.88  ? 114 PHE A CA  1 
ATOM   334  C C   . PHE A 1 114 ? 105.183 116.898 107.107 1.00 55.88  ? 114 PHE A C   1 
ATOM   335  O O   . PHE A 1 114 ? 106.281 117.333 107.466 1.00 55.88  ? 114 PHE A O   1 
ATOM   336  C CB  . PHE A 1 114 ? 104.050 118.947 106.316 1.00 55.88  ? 114 PHE A CB  1 
ATOM   337  C CG  . PHE A 1 114 ? 103.711 119.844 105.166 1.00 55.88  ? 114 PHE A CG  1 
ATOM   338  C CD1 . PHE A 1 114 ? 104.094 119.533 103.876 1.00 55.88  ? 114 PHE A CD1 1 
ATOM   339  C CD2 . PHE A 1 114 ? 103.016 121.018 105.386 1.00 55.88  ? 114 PHE A CD2 1 
ATOM   340  C CE1 . PHE A 1 114 ? 103.784 120.372 102.833 1.00 55.88  ? 114 PHE A CE1 1 
ATOM   341  C CE2 . PHE A 1 114 ? 102.702 121.858 104.343 1.00 55.88  ? 114 PHE A CE2 1 
ATOM   342  C CZ  . PHE A 1 114 ? 103.085 121.531 103.064 1.00 55.88  ? 114 PHE A CZ  1 
ATOM   343  N N   . VAL A 1 115 ? 104.558 115.901 107.738 1.00 59.01  ? 115 VAL A N   1 
ATOM   344  C CA  . VAL A 1 115 ? 105.145 115.238 108.897 1.00 59.01  ? 115 VAL A CA  1 
ATOM   345  C C   . VAL A 1 115 ? 106.401 114.466 108.506 1.00 59.01  ? 115 VAL A C   1 
ATOM   346  O O   . VAL A 1 115 ? 107.363 114.396 109.278 1.00 59.01  ? 115 VAL A O   1 
ATOM   347  C CB  . VAL A 1 115 ? 104.072 114.349 109.557 1.00 59.01  ? 115 VAL A CB  1 
ATOM   348  C CG1 . VAL A 1 115 ? 104.640 113.466 110.644 1.00 59.01  ? 115 VAL A CG1 1 
ATOM   349  C CG2 . VAL A 1 115 ? 102.994 115.222 110.153 1.00 59.01  ? 115 VAL A CG2 1 
ATOM   350  N N   . PHE A 1 116 ? 106.459 113.948 107.287 1.00 66.71  ? 116 PHE A N   1 
ATOM   351  C CA  . PHE A 1 116 ? 107.632 113.197 106.862 1.00 66.71  ? 116 PHE A CA  1 
ATOM   352  C C   . PHE A 1 116 ? 108.822 114.079 106.499 1.00 66.71  ? 116 PHE A C   1 
ATOM   353  O O   . PHE A 1 116 ? 109.894 113.540 106.208 1.00 66.71  ? 116 PHE A O   1 
ATOM   354  C CB  . PHE A 1 116 ? 107.269 112.310 105.676 1.00 66.71  ? 116 PHE A CB  1 
ATOM   355  C CG  . PHE A 1 116 ? 106.247 111.269 106.001 1.00 66.71  ? 116 PHE A CG  1 
ATOM   356  C CD1 . PHE A 1 116 ? 106.614 110.097 106.633 1.00 66.71  ? 116 PHE A CD1 1 
ATOM   357  C CD2 . PHE A 1 116 ? 104.916 111.465 105.676 1.00 66.71  ? 116 PHE A CD2 1 
ATOM   358  C CE1 . PHE A 1 116 ? 105.673 109.138 106.933 1.00 66.71  ? 116 PHE A CE1 1 
ATOM   359  C CE2 . PHE A 1 116 ? 103.972 110.510 105.974 1.00 66.71  ? 116 PHE A CE2 1 
ATOM   360  C CZ  . PHE A 1 116 ? 104.353 109.345 106.597 1.00 66.71  ? 116 PHE A CZ  1 
ATOM   361  N N   . TRP A 1 117 ? 108.671 115.404 106.490 1.00 61.18  ? 117 TRP A N   1 
ATOM   362  C CA  . TRP A 1 117 ? 109.785 116.291 106.150 1.00 61.18  ? 117 TRP A CA  1 
ATOM   363  C C   . TRP A 1 117 ? 110.823 116.597 107.241 1.00 61.18  ? 117 TRP A C   1 
ATOM   364  O O   . TRP A 1 117 ? 111.988 116.777 106.868 1.00 61.18  ? 117 TRP A O   1 
ATOM   365  C CB  . TRP A 1 117 ? 109.289 117.631 105.594 1.00 61.18  ? 117 TRP A CB  1 
ATOM   366  C CG  . TRP A 1 117 ? 108.707 117.560 104.224 1.00 61.18  ? 117 TRP A CG  1 
ATOM   367  C CD1 . TRP A 1 117 ? 108.388 116.440 103.525 1.00 61.18  ? 117 TRP A CD1 1 
ATOM   368  C CD2 . TRP A 1 117 ? 108.488 118.659 103.339 1.00 61.18  ? 117 TRP A CD2 1 
ATOM   369  N NE1 . TRP A 1 117 ? 107.915 116.775 102.283 1.00 61.18  ? 117 TRP A NE1 1 
ATOM   370  C CE2 . TRP A 1 117 ? 107.974 118.135 102.143 1.00 61.18  ? 117 TRP A CE2 1 
ATOM   371  C CE3 . TRP A 1 117 ? 108.648 120.040 103.454 1.00 61.18  ? 117 TRP A CE3 1 
ATOM   372  C CZ2 . TRP A 1 117 ? 107.621 118.940 101.071 1.00 61.18  ? 117 TRP A CZ2 1 
ATOM   373  C CZ3 . TRP A 1 117 ? 108.298 120.836 102.387 1.00 61.18  ? 117 TRP A CZ3 1 
ATOM   374  C CH2 . TRP A 1 117 ? 107.793 120.285 101.210 1.00 61.18  ? 117 TRP A CH2 1 
ATOM   375  N N   . PRO A 1 118 ? 110.497 116.752 108.543 1.00 63.09  ? 118 PRO A N   1 
ATOM   376  C CA  . PRO A 1 118 ? 111.577 117.028 109.513 1.00 63.09  ? 118 PRO A CA  1 
ATOM   377  C C   . PRO A 1 118 ? 112.626 115.938 109.661 1.00 63.09  ? 118 PRO A C   1 
ATOM   378  O O   . PRO A 1 118 ? 113.798 116.267 109.887 1.00 63.09  ? 118 PRO A O   1 
ATOM   379  C CB  . PRO A 1 118 ? 110.820 117.239 110.826 1.00 63.09  ? 118 PRO A CB  1 
ATOM   380  C CG  . PRO A 1 118 ? 109.570 117.768 110.422 1.00 63.09  ? 118 PRO A CG  1 
ATOM   381  C CD  . PRO A 1 118 ? 109.197 117.067 109.166 1.00 63.09  ? 118 PRO A CD  1 
ATOM   382  N N   . PHE A 1 119 ? 112.262 114.663 109.527 1.00 68.27  ? 119 PHE A N   1 
ATOM   383  C CA  . PHE A 1 119 ? 113.287 113.627 109.588 1.00 68.27  ? 119 PHE A CA  1 
ATOM   384  C C   . PHE A 1 119 ? 114.198 113.674 108.369 1.00 68.27  ? 119 PHE A C   1 
ATOM   385  O O   . PHE A 1 119 ? 115.372 113.298 108.455 1.00 68.27  ? 119 PHE A O   1 
ATOM   386  C CB  . PHE A 1 119 ? 112.653 112.248 109.720 1.00 68.27  ? 119 PHE A CB  1 
ATOM   387  C CG  . PHE A 1 119 ? 113.652 111.151 109.885 1.00 68.27  ? 119 PHE A CG  1 
ATOM   388  C CD1 . PHE A 1 119 ? 114.327 110.995 111.080 1.00 68.27  ? 119 PHE A CD1 1 
ATOM   389  C CD2 . PHE A 1 119 ? 113.931 110.286 108.839 1.00 68.27  ? 119 PHE A CD2 1 
ATOM   390  C CE1 . PHE A 1 119 ? 115.258 109.992 111.235 1.00 68.27  ? 119 PHE A CE1 1 
ATOM   391  C CE2 . PHE A 1 119 ? 114.863 109.280 108.986 1.00 68.27  ? 119 PHE A CE2 1 
ATOM   392  C CZ  . PHE A 1 119 ? 115.527 109.133 110.188 1.00 68.27  ? 119 PHE A CZ  1 
ATOM   393  N N   . SER A 1 120 ? 113.682 114.147 107.237 1.00 67.44  ? 120 SER A N   1 
ATOM   394  C CA  . SER A 1 120 ? 114.537 114.398 106.085 1.00 67.44  ? 120 SER A CA  1 
ATOM   395  C C   . SER A 1 120 ? 115.440 115.599 106.329 1.00 67.44  ? 120 SER A C   1 
ATOM   396  O O   . SER A 1 120 ? 116.651 115.536 106.092 1.00 67.44  ? 120 SER A O   1 
ATOM   397  C CB  . SER A 1 120 ? 113.677 114.617 104.843 1.00 67.44  ? 120 SER A CB  1 
ATOM   398  O OG  . SER A 1 120 ? 112.963 113.440 104.508 1.00 67.44  ? 120 SER A OG  1 
ATOM   399  N N   . LEU A 1 121 ? 114.871 116.693 106.833 1.00 70.45  ? 121 LEU A N   1 
ATOM   400  C CA  . LEU A 1 121 ? 115.543 117.985 106.904 1.00 70.45  ? 121 LEU A CA  1 
ATOM   401  C C   . LEU A 1 121 ? 116.118 118.276 108.284 1.00 70.45  ? 121 LEU A C   1 
ATOM   402  O O   . LEU A 1 121 ? 116.228 119.446 108.664 1.00 70.45  ? 121 LEU A O   1 
ATOM   403  C CB  . LEU A 1 121 ? 114.587 119.107 106.501 1.00 70.45  ? 121 LEU A CB  1 
ATOM   404  C CG  . LEU A 1 121 ? 114.324 119.414 105.027 1.00 70.45  ? 121 LEU A CG  1 
ATOM   405  C CD1 . LEU A 1 121 ? 113.430 118.381 104.368 1.00 70.45  ? 121 LEU A CD1 1 
ATOM   406  C CD2 . LEU A 1 121 ? 113.714 120.797 104.897 1.00 70.45  ? 121 LEU A CD2 1 
ATOM   407  N N   . LYS A 1 122 ? 116.446 117.233 109.055 1.00 74.88  ? 122 LYS A N   1 
ATOM   408  C CA  . LYS A 1 122 ? 117.074 117.407 110.365 1.00 74.88  ? 122 LYS A CA  1 
ATOM   409  C C   . LYS A 1 122 ? 118.409 118.152 110.327 1.00 74.88  ? 122 LYS A C   1 
ATOM   410  O O   . LYS A 1 122 ? 118.789 118.753 111.338 1.00 74.88  ? 122 LYS A O   1 
ATOM   411  C CB  . LYS A 1 122 ? 117.266 116.045 111.037 1.00 74.88  ? 122 LYS A CB  1 
ATOM   412  C CG  . LYS A 1 122 ? 118.243 115.118 110.340 1.00 74.88  ? 122 LYS A CG  1 
ATOM   413  C CD  . LYS A 1 122 ? 118.346 113.787 111.061 1.00 74.88  ? 122 LYS A CD  1 
ATOM   414  C CE  . LYS A 1 122 ? 119.358 112.875 110.393 1.00 74.88  ? 122 LYS A CE  1 
ATOM   415  N NZ  . LYS A 1 122 ? 118.914 112.451 109.039 1.00 74.88  ? 122 LYS A NZ  1 
ATOM   416  N N   . LEU A 1 123 ? 119.118 118.161 109.195 1.00 82.61  ? 123 LEU A N   1 
ATOM   417  C CA  . LEU A 1 123 ? 120.376 118.899 109.133 1.00 82.61  ? 123 LEU A CA  1 
ATOM   418  C C   . LEU A 1 123 ? 120.176 120.410 109.210 1.00 82.61  ? 123 LEU A C   1 
ATOM   419  O O   . LEU A 1 123 ? 121.081 121.120 109.660 1.00 82.61  ? 123 LEU A O   1 
ATOM   420  C CB  . LEU A 1 123 ? 121.153 118.502 107.874 1.00 82.61  ? 123 LEU A CB  1 
ATOM   421  C CG  . LEU A 1 123 ? 122.535 119.121 107.641 1.00 82.61  ? 123 LEU A CG  1 
ATOM   422  C CD1 . LEU A 1 123 ? 123.491 118.105 107.173 1.00 82.61  ? 123 LEU A CD1 1 
ATOM   423  C CD2 . LEU A 1 123 ? 122.444 120.207 106.591 1.00 82.61  ? 123 LEU A CD2 1 
ATOM   424  N N   . LEU A 1 124 ? 118.994 120.915 108.857 1.00 81.50  ? 124 LEU A N   1 
ATOM   425  C CA  . LEU A 1 124 ? 118.753 122.352 108.922 1.00 81.50  ? 124 LEU A CA  1 
ATOM   426  C C   . LEU A 1 124 ? 118.697 122.893 110.350 1.00 81.50  ? 124 LEU A C   1 
ATOM   427  O O   . LEU A 1 124 ? 118.744 124.114 110.528 1.00 81.50  ? 124 LEU A O   1 
ATOM   428  C CB  . LEU A 1 124 ? 117.463 122.709 108.178 1.00 81.50  ? 124 LEU A CB  1 
ATOM   429  C CG  . LEU A 1 124 ? 117.540 122.992 106.671 1.00 81.50  ? 124 LEU A CG  1 
ATOM   430  C CD1 . LEU A 1 124 ? 118.476 124.159 106.404 1.00 81.50  ? 124 LEU A CD1 1 
ATOM   431  C CD2 . LEU A 1 124 ? 117.931 121.785 105.830 1.00 81.50  ? 124 LEU A CD2 1 
ATOM   432  N N   . TRP A 1 125 ? 118.608 122.027 111.367 1.00 76.19  ? 125 TRP A N   1 
ATOM   433  C CA  . TRP A 1 125 ? 118.800 122.443 112.751 1.00 76.19  ? 125 TRP A CA  1 
ATOM   434  C C   . TRP A 1 125 ? 119.801 121.565 113.494 1.00 76.19  ? 125 TRP A C   1 
ATOM   435  O O   . TRP A 1 125 ? 119.919 121.692 114.718 1.00 76.19  ? 125 TRP A O   1 
ATOM   436  C CB  . TRP A 1 125 ? 117.472 122.465 113.517 1.00 76.19  ? 125 TRP A CB  1 
ATOM   437  C CG  . TRP A 1 125 ? 116.787 121.142 113.603 1.00 76.19  ? 125 TRP A CG  1 
ATOM   438  C CD1 . TRP A 1 125 ? 116.982 120.173 114.542 1.00 76.19  ? 125 TRP A CD1 1 
ATOM   439  C CD2 . TRP A 1 125 ? 115.774 120.651 112.725 1.00 76.19  ? 125 TRP A CD2 1 
ATOM   440  N NE1 . TRP A 1 125 ? 116.163 119.103 114.293 1.00 76.19  ? 125 TRP A NE1 1 
ATOM   441  C CE2 . TRP A 1 125 ? 115.410 119.373 113.182 1.00 76.19  ? 125 TRP A CE2 1 
ATOM   442  C CE3 . TRP A 1 125 ? 115.144 121.168 111.592 1.00 76.19  ? 125 TRP A CE3 1 
ATOM   443  C CZ2 . TRP A 1 125 ? 114.445 118.606 112.547 1.00 76.19  ? 125 TRP A CZ2 1 
ATOM   444  C CZ3 . TRP A 1 125 ? 114.186 120.406 110.966 1.00 76.19  ? 125 TRP A CZ3 1 
ATOM   445  C CH2 . TRP A 1 125 ? 113.847 119.139 111.442 1.00 76.19  ? 125 TRP A CH2 1 
ATOM   446  N N   . ALA A 1 126 ? 120.488 120.658 112.799 1.00 84.49  ? 126 ALA A N   1 
ATOM   447  C CA  . ALA A 1 126 ? 121.553 119.888 113.442 1.00 84.49  ? 126 ALA A CA  1 
ATOM   448  C C   . ALA A 1 126 ? 122.717 120.711 114.006 1.00 84.49  ? 126 ALA A C   1 
ATOM   449  O O   . ALA A 1 126 ? 123.168 120.373 115.114 1.00 84.49  ? 126 ALA A O   1 
ATOM   450  C CB  . ALA A 1 126 ? 122.070 118.810 112.477 1.00 84.49  ? 126 ALA A CB  1 
ATOM   451  N N   . PRO A 1 127 ? 123.260 121.757 113.352 1.00 91.08  ? 127 PRO A N   1 
ATOM   452  C CA  . PRO A 1 127 ? 124.273 122.555 114.063 1.00 91.08  ? 127 PRO A CA  1 
ATOM   453  C C   . PRO A 1 127 ? 123.697 123.405 115.178 1.00 91.08  ? 127 PRO A C   1 
ATOM   454  O O   . PRO A 1 127 ? 124.420 123.720 116.131 1.00 91.08  ? 127 PRO A O   1 
ATOM   455  C CB  . PRO A 1 127 ? 124.889 123.420 112.958 1.00 91.08  ? 127 PRO A CB  1 
ATOM   456  C CG  . PRO A 1 127 ? 123.861 123.511 111.939 1.00 91.08  ? 127 PRO A CG  1 
ATOM   457  C CD  . PRO A 1 127 ? 123.180 122.191 111.941 1.00 91.08  ? 127 PRO A CD  1 
ATOM   458  N N   . LEU A 1 128 ? 122.414 123.768 115.097 1.00 91.11  ? 128 LEU A N   1 
ATOM   459  C CA  . LEU A 1 128 ? 121.771 124.500 116.183 1.00 91.11  ? 128 LEU A CA  1 
ATOM   460  C C   . LEU A 1 128 ? 121.639 123.643 117.435 1.00 91.11  ? 128 LEU A C   1 
ATOM   461  O O   . LEU A 1 128 ? 121.664 124.170 118.553 1.00 91.11  ? 128 LEU A O   1 
ATOM   462  C CB  . LEU A 1 128 ? 120.399 124.998 115.726 1.00 91.11  ? 128 LEU A CB  1 
ATOM   463  C CG  . LEU A 1 128 ? 119.567 125.851 116.683 1.00 91.11  ? 128 LEU A CG  1 
ATOM   464  C CD1 . LEU A 1 128 ? 120.302 127.135 117.017 1.00 91.11  ? 128 LEU A CD1 1 
ATOM   465  C CD2 . LEU A 1 128 ? 118.206 126.150 116.080 1.00 91.11  ? 128 LEU A CD2 1 
ATOM   466  N N   . VAL A 1 129 ? 121.531 122.325 117.271 1.00 89.71  ? 129 VAL A N   1 
ATOM   467  C CA  . VAL A 1 129 ? 121.380 121.430 118.410 1.00 89.71  ? 129 VAL A CA  1 
ATOM   468  C C   . VAL A 1 129 ? 122.703 120.765 118.799 1.00 89.71  ? 129 VAL A C   1 
ATOM   469  O O   . VAL A 1 129 ? 122.811 120.232 119.914 1.00 89.71  ? 129 VAL A O   1 
ATOM   470  C CB  . VAL A 1 129 ? 120.286 120.378 118.114 1.00 89.71  ? 129 VAL A CB  1 
ATOM   471  C CG1 . VAL A 1 129 ? 120.806 119.275 117.216 1.00 89.71  ? 129 VAL A CG1 1 
ATOM   472  C CG2 . VAL A 1 129 ? 119.646 119.844 119.384 1.00 89.71  ? 129 VAL A CG2 1 
ATOM   473  N N   . ASP A 1 130 ? 123.717 120.806 117.935 1.00 95.82  ? 130 ASP A N   1 
ATOM   474  C CA  . ASP A 1 130 ? 125.046 120.320 118.280 1.00 95.82  ? 130 ASP A CA  1 
ATOM   475  C C   . ASP A 1 130 ? 126.002 121.435 118.673 1.00 95.82  ? 130 ASP A C   1 
ATOM   476  O O   . ASP A 1 130 ? 127.142 121.149 119.050 1.00 95.82  ? 130 ASP A O   1 
ATOM   477  C CB  . ASP A 1 130 ? 125.649 119.527 117.117 1.00 95.82  ? 130 ASP A CB  1 
ATOM   478  C CG  . ASP A 1 130 ? 124.982 118.185 116.921 1.00 95.82  ? 130 ASP A CG  1 
ATOM   479  O OD1 . ASP A 1 130 ? 124.436 117.647 117.905 1.00 95.82  ? 130 ASP A OD1 1 
ATOM   480  O OD2 . ASP A 1 130 ? 125.022 117.659 115.789 1.00 95.82  ? 130 ASP A OD2 1 
ATOM   481  N N   . ALA A 1 131 ? 125.575 122.694 118.593 1.00 101.10 ? 131 ALA A N   1 
ATOM   482  C CA  . ALA A 1 131 ? 126.441 123.806 118.956 1.00 101.10 ? 131 ALA A CA  1 
ATOM   483  C C   . ALA A 1 131 ? 126.284 124.232 120.407 1.00 101.10 ? 131 ALA A C   1 
ATOM   484  O O   . ALA A 1 131 ? 127.213 124.818 120.974 1.00 101.10 ? 131 ALA A O   1 
ATOM   485  C CB  . ALA A 1 131 ? 126.167 125.005 118.046 1.00 101.10 ? 131 ALA A CB  1 
ATOM   486  N N   . VAL A 1 132 ? 125.137 123.958 121.021 1.00 106.01 ? 132 VAL A N   1 
ATOM   487  C CA  . VAL A 1 132 ? 124.874 124.386 122.387 1.00 106.01 ? 132 VAL A CA  1 
ATOM   488  C C   . VAL A 1 132 ? 124.670 123.167 123.277 1.00 106.01 ? 132 VAL A C   1 
ATOM   489  O O   . VAL A 1 132 ? 124.154 122.130 122.848 1.00 106.01 ? 132 VAL A O   1 
ATOM   490  C CB  . VAL A 1 132 ? 123.663 125.343 122.462 1.00 106.01 ? 132 VAL A CB  1 
ATOM   491  C CG1 . VAL A 1 132 ? 123.984 126.643 121.750 1.00 106.01 ? 132 VAL A CG1 1 
ATOM   492  C CG2 . VAL A 1 132 ? 122.434 124.712 121.838 1.00 106.01 ? 132 VAL A CG2 1 
ATOM   493  N N   . TYR A 1 133 ? 125.107 123.303 124.527 1.00 114.70 ? 133 TYR A N   1 
ATOM   494  C CA  . TYR A 1 133 ? 124.975 122.272 125.548 1.00 114.70 ? 133 TYR A CA  1 
ATOM   495  C C   . TYR A 1 133 ? 125.130 122.945 126.904 1.00 114.70 ? 133 TYR A C   1 
ATOM   496  O O   . TYR A 1 133 ? 125.428 124.138 126.994 1.00 114.70 ? 133 TYR A O   1 
ATOM   497  C CB  . TYR A 1 133 ? 125.995 121.141 125.352 1.00 114.70 ? 133 TYR A CB  1 
ATOM   498  C CG  . TYR A 1 133 ? 127.452 121.548 125.445 1.00 114.70 ? 133 TYR A CG  1 
ATOM   499  C CD1 . TYR A 1 133 ? 128.131 122.032 124.332 1.00 114.70 ? 133 TYR A CD1 1 
ATOM   500  C CD2 . TYR A 1 133 ? 128.161 121.407 126.634 1.00 114.70 ? 133 TYR A CD2 1 
ATOM   501  C CE1 . TYR A 1 133 ? 129.465 122.391 124.406 1.00 114.70 ? 133 TYR A CE1 1 
ATOM   502  C CE2 . TYR A 1 133 ? 129.495 121.765 126.719 1.00 114.70 ? 133 TYR A CE2 1 
ATOM   503  C CZ  . TYR A 1 133 ? 130.141 122.255 125.602 1.00 114.70 ? 133 TYR A CZ  1 
ATOM   504  O OH  . TYR A 1 133 ? 131.468 122.610 125.683 1.00 114.70 ? 133 TYR A OH  1 
ATOM   505  N N   . VAL A 1 134 ? 124.923 122.170 127.961 1.00 116.42 ? 134 VAL A N   1 
ATOM   506  C CA  . VAL A 1 134 ? 124.950 122.706 129.310 1.00 116.42 ? 134 VAL A CA  1 
ATOM   507  C C   . VAL A 1 134 ? 126.264 122.330 129.986 1.00 116.42 ? 134 VAL A C   1 
ATOM   508  O O   . VAL A 1 134 ? 126.936 121.362 129.620 1.00 116.42 ? 134 VAL A O   1 
ATOM   509  C CB  . VAL A 1 134 ? 123.734 122.235 130.139 1.00 116.42 ? 134 VAL A CB  1 
ATOM   510  C CG1 . VAL A 1 134 ? 122.449 122.774 129.533 1.00 116.42 ? 134 VAL A CG1 1 
ATOM   511  C CG2 . VAL A 1 134 ? 123.686 120.730 130.202 1.00 116.42 ? 134 VAL A CG2 1 
ATOM   512  N N   . LYS A 1 135 ? 126.632 123.119 130.993 1.00 121.94 ? 135 LYS A N   1 
ATOM   513  C CA  . LYS A 1 135 ? 127.921 122.985 131.658 1.00 121.94 ? 135 LYS A CA  1 
ATOM   514  C C   . LYS A 1 135 ? 127.916 121.796 132.614 1.00 121.94 ? 135 LYS A C   1 
ATOM   515  O O   . LYS A 1 135 ? 126.897 121.503 133.248 1.00 121.94 ? 135 LYS A O   1 
ATOM   516  C CB  . LYS A 1 135 ? 128.250 124.277 132.415 1.00 121.94 ? 135 LYS A CB  1 
ATOM   517  C CG  . LYS A 1 135 ? 129.651 124.354 133.014 1.00 121.94 ? 135 LYS A CG  1 
ATOM   518  C CD  . LYS A 1 135 ? 129.893 125.692 133.690 1.00 121.94 ? 135 LYS A CD  1 
ATOM   519  C CE  . LYS A 1 135 ? 131.281 125.755 134.304 1.00 121.94 ? 135 LYS A CE  1 
ATOM   520  N NZ  . LYS A 1 135 ? 131.529 127.058 134.981 1.00 121.94 ? 135 LYS A NZ  1 
ATOM   521  N N   . ASN A 1 136 ? 129.070 121.111 132.691 1.00 120.41 ? 136 ASN A N   1 
ATOM   522  C CA  . ASN A 1 136 ? 129.316 119.970 133.585 1.00 120.41 ? 136 ASN A CA  1 
ATOM   523  C C   . ASN A 1 136 ? 128.341 118.826 133.315 1.00 120.41 ? 136 ASN A C   1 
ATOM   524  O O   . ASN A 1 136 ? 127.788 118.222 134.236 1.00 120.41 ? 136 ASN A O   1 
ATOM   525  C CB  . ASN A 1 136 ? 129.284 120.385 135.061 1.00 120.41 ? 136 ASN A CB  1 
ATOM   526  C CG  . ASN A 1 136 ? 130.466 121.254 135.447 1.00 120.41 ? 136 ASN A CG  1 
ATOM   527  O OD1 . ASN A 1 136 ? 131.598 121.003 135.035 1.00 120.41 ? 136 ASN A OD1 1 
ATOM   528  N ND2 . ASN A 1 136 ? 130.207 122.284 136.245 1.00 120.41 ? 136 ASN A ND2 1 
ATOM   529  N N   . PHE A 1 137 ? 128.144 118.525 132.035 1.00 116.06 ? 137 PHE A N   1 
ATOM   530  C CA  . PHE A 1 137 ? 127.187 117.521 131.598 1.00 116.06 ? 137 PHE A CA  1 
ATOM   531  C C   . PHE A 1 137 ? 127.610 117.106 130.194 1.00 116.06 ? 137 PHE A C   1 
ATOM   532  O O   . PHE A 1 137 ? 128.521 117.696 129.608 1.00 116.06 ? 137 PHE A O   1 
ATOM   533  C CB  . PHE A 1 137 ? 125.761 118.086 131.660 1.00 116.06 ? 137 PHE A CB  1 
ATOM   534  C CG  . PHE A 1 137 ? 124.671 117.060 131.516 1.00 116.06 ? 137 PHE A CG  1 
ATOM   535  C CD1 . PHE A 1 137 ? 124.402 116.168 132.542 1.00 116.06 ? 137 PHE A CD1 1 
ATOM   536  C CD2 . PHE A 1 137 ? 123.888 117.018 130.374 1.00 116.06 ? 137 PHE A CD2 1 
ATOM   537  C CE1 . PHE A 1 137 ? 123.390 115.231 132.420 1.00 116.06 ? 137 PHE A CE1 1 
ATOM   538  C CE2 . PHE A 1 137 ? 122.873 116.086 130.247 1.00 116.06 ? 137 PHE A CE2 1 
ATOM   539  C CZ  . PHE A 1 137 ? 122.625 115.192 131.270 1.00 116.06 ? 137 PHE A CZ  1 
ATOM   540  N N   . GLY A 1 138 ? 126.962 116.067 129.671 1.00 109.50 ? 138 GLY A N   1 
ATOM   541  C CA  . GLY A 1 138 ? 127.305 115.573 128.348 1.00 109.50 ? 138 GLY A CA  1 
ATOM   542  C C   . GLY A 1 138 ? 126.924 116.562 127.259 1.00 109.50 ? 138 GLY A C   1 
ATOM   543  O O   . GLY A 1 138 ? 125.908 117.254 127.344 1.00 109.50 ? 138 GLY A O   1 
ATOM   544  N N   . ARG A 1 139 ? 127.773 116.636 126.229 1.00 107.31 ? 139 ARG A N   1 
ATOM   545  C CA  . ARG A 1 139 ? 127.548 117.574 125.133 1.00 107.31 ? 139 ARG A CA  1 
ATOM   546  C C   . ARG A 1 139 ? 126.339 117.169 124.301 1.00 107.31 ? 139 ARG A C   1 
ATOM   547  O O   . ARG A 1 139 ? 125.568 118.027 123.855 1.00 107.31 ? 139 ARG A O   1 
ATOM   548  C CB  . ARG A 1 139 ? 128.799 117.660 124.259 1.00 107.31 ? 139 ARG A CB  1 
ATOM   549  C CG  . ARG A 1 139 ? 128.721 118.693 123.150 1.00 107.31 ? 139 ARG A CG  1 
ATOM   550  C CD  . ARG A 1 139 ? 129.995 118.722 122.319 1.00 107.31 ? 139 ARG A CD  1 
ATOM   551  N NE  . ARG A 1 139 ? 130.176 117.497 121.546 1.00 107.31 ? 139 ARG A NE  1 
ATOM   552  C CZ  . ARG A 1 139 ? 131.283 117.195 120.874 1.00 107.31 ? 139 ARG A CZ  1 
ATOM   553  N NH1 . ARG A 1 139 ? 132.314 118.029 120.878 1.00 107.31 ? 139 ARG A NH1 1 
ATOM   554  N NH2 . ARG A 1 139 ? 131.360 116.057 120.197 1.00 107.31 ? 139 ARG A NH2 1 
ATOM   555  N N   . ARG A 1 140 ? 126.150 115.869 124.093 1.00 99.12  ? 140 ARG A N   1 
ATOM   556  C CA  . ARG A 1 140 ? 124.993 115.376 123.365 1.00 99.12  ? 140 ARG A CA  1 
ATOM   557  C C   . ARG A 1 140 ? 123.904 114.835 124.276 1.00 99.12  ? 140 ARG A C   1 
ATOM   558  O O   . ARG A 1 140 ? 122.761 114.695 123.830 1.00 99.12  ? 140 ARG A O   1 
ATOM   559  C CB  . ARG A 1 140 ? 125.420 114.290 122.378 1.00 99.12  ? 140 ARG A CB  1 
ATOM   560  C CG  . ARG A 1 140 ? 126.367 114.793 121.316 1.00 99.12  ? 140 ARG A CG  1 
ATOM   561  C CD  . ARG A 1 140 ? 125.665 115.679 120.308 1.00 99.12  ? 140 ARG A CD  1 
ATOM   562  N NE  . ARG A 1 140 ? 126.554 116.031 119.206 1.00 99.12  ? 140 ARG A NE  1 
ATOM   563  C CZ  . ARG A 1 140 ? 127.311 117.123 119.173 1.00 99.12  ? 140 ARG A CZ  1 
ATOM   564  N NH1 . ARG A 1 140 ? 127.279 117.985 120.178 1.00 99.12  ? 140 ARG A NH1 1 
ATOM   565  N NH2 . ARG A 1 140 ? 128.093 117.358 118.129 1.00 99.12  ? 140 ARG A NH2 1 
ATOM   566  N N   . LYS A 1 141 ? 124.226 114.535 125.537 1.00 103.91 ? 141 LYS A N   1 
ATOM   567  C CA  . LYS A 1 141 ? 123.184 114.238 126.512 1.00 103.91 ? 141 LYS A CA  1 
ATOM   568  C C   . LYS A 1 141 ? 122.391 115.480 126.892 1.00 103.91 ? 141 LYS A C   1 
ATOM   569  O O   . LYS A 1 141 ? 121.271 115.354 127.395 1.00 103.91 ? 141 LYS A O   1 
ATOM   570  C CB  . LYS A 1 141 ? 123.782 113.612 127.774 1.00 103.91 ? 141 LYS A CB  1 
ATOM   571  C CG  . LYS A 1 141 ? 124.321 112.198 127.614 1.00 103.91 ? 141 LYS A CG  1 
ATOM   572  C CD  . LYS A 1 141 ? 124.853 111.677 128.948 1.00 103.91 ? 141 LYS A CD  1 
ATOM   573  C CE  . LYS A 1 141 ? 125.419 110.269 128.831 1.00 103.91 ? 141 LYS A CE  1 
ATOM   574  N NZ  . LYS A 1 141 ? 125.962 109.765 130.127 1.00 103.91 ? 141 LYS A NZ  1 
ATOM   575  N N   . SER A 1 142 ? 122.948 116.675 126.666 1.00 103.18 ? 142 SER A N   1 
ATOM   576  C CA  . SER A 1 142 ? 122.240 117.915 126.958 1.00 103.18 ? 142 SER A CA  1 
ATOM   577  C C   . SER A 1 142 ? 121.066 118.152 126.023 1.00 103.18 ? 142 SER A C   1 
ATOM   578  O O   . SER A 1 142 ? 120.188 118.955 126.349 1.00 103.18 ? 142 SER A O   1 
ATOM   579  C CB  . SER A 1 142 ? 123.196 119.103 126.875 1.00 103.18 ? 142 SER A CB  1 
ATOM   580  O OG  . SER A 1 142 ? 122.504 120.322 127.085 1.00 103.18 ? 142 SER A OG  1 
ATOM   581  N N   . TRP A 1 143 ? 121.047 117.507 124.859 1.00 97.48  ? 143 TRP A N   1 
ATOM   582  C CA  . TRP A 1 143 ? 119.883 117.526 123.985 1.00 97.48  ? 143 TRP A CA  1 
ATOM   583  C C   . TRP A 1 143 ? 119.316 116.137 123.758 1.00 97.48  ? 143 TRP A C   1 
ATOM   584  O O   . TRP A 1 143 ? 118.419 115.974 122.925 1.00 97.48  ? 143 TRP A O   1 
ATOM   585  C CB  . TRP A 1 143 ? 120.216 118.186 122.649 1.00 97.48  ? 143 TRP A CB  1 
ATOM   586  C CG  . TRP A 1 143 ? 120.416 119.649 122.782 1.00 97.48  ? 143 TRP A CG  1 
ATOM   587  C CD1 . TRP A 1 143 ? 121.602 120.309 122.848 1.00 97.48  ? 143 TRP A CD1 1 
ATOM   588  C CD2 . TRP A 1 143 ? 119.393 120.644 122.891 1.00 97.48  ? 143 TRP A CD2 1 
ATOM   589  N NE1 . TRP A 1 143 ? 121.386 121.659 122.982 1.00 97.48  ? 143 TRP A NE1 1 
ATOM   590  C CE2 . TRP A 1 143 ? 120.036 121.890 123.012 1.00 97.48  ? 143 TRP A CE2 1 
ATOM   591  C CE3 . TRP A 1 143 ? 117.996 120.601 122.894 1.00 97.48  ? 143 TRP A CE3 1 
ATOM   592  C CZ2 . TRP A 1 143 ? 119.329 123.085 123.136 1.00 97.48  ? 143 TRP A CZ2 1 
ATOM   593  C CZ3 . TRP A 1 143 ? 117.296 121.788 123.018 1.00 97.48  ? 143 TRP A CZ3 1 
ATOM   594  C CH2 . TRP A 1 143 ? 117.963 123.013 123.136 1.00 97.48  ? 143 TRP A CH2 1 
ATOM   595  N N   . LEU A 1 144 ? 119.819 115.129 124.467 1.00 86.05  ? 144 LEU A N   1 
ATOM   596  C CA  . LEU A 1 144 ? 119.145 113.840 124.462 1.00 86.05  ? 144 LEU A CA  1 
ATOM   597  C C   . LEU A 1 144 ? 117.984 113.837 125.447 1.00 86.05  ? 144 LEU A C   1 
ATOM   598  O O   . LEU A 1 144 ? 116.824 113.725 125.044 1.00 86.05  ? 144 LEU A O   1 
ATOM   599  C CB  . LEU A 1 144 ? 120.132 112.717 124.779 1.00 86.05  ? 144 LEU A CB  1 
ATOM   600  C CG  . LEU A 1 144 ? 119.504 111.325 124.813 1.00 86.05  ? 144 LEU A CG  1 
ATOM   601  C CD1 . LEU A 1 144 ? 118.850 111.009 123.492 1.00 86.05  ? 144 LEU A CD1 1 
ATOM   602  C CD2 . LEU A 1 144 ? 120.555 110.284 125.145 1.00 86.05  ? 144 LEU A CD2 1 
ATOM   603  N N   . VAL A 1 145 ? 118.271 114.007 126.736 1.00 83.28  ? 145 VAL A N   1 
ATOM   604  C CA  . VAL A 1 145 ? 117.230 113.886 127.759 1.00 83.28  ? 145 VAL A CA  1 
ATOM   605  C C   . VAL A 1 145 ? 116.167 114.994 127.772 1.00 83.28  ? 145 VAL A C   1 
ATOM   606  O O   . VAL A 1 145 ? 115.018 114.653 128.091 1.00 83.28  ? 145 VAL A O   1 
ATOM   607  C CB  . VAL A 1 145 ? 117.843 113.677 129.163 1.00 83.28  ? 145 VAL A CB  1 
ATOM   608  C CG1 . VAL A 1 145 ? 118.556 112.354 129.210 1.00 83.28  ? 145 VAL A CG1 1 
ATOM   609  C CG2 . VAL A 1 145 ? 118.820 114.752 129.577 1.00 83.28  ? 145 VAL A CG2 1 
ATOM   610  N N   . PRO A 1 146 ? 116.404 116.279 127.422 1.00 79.16  ? 146 PRO A N   1 
ATOM   611  C CA  . PRO A 1 146 ? 115.238 117.177 127.369 1.00 79.16  ? 146 PRO A CA  1 
ATOM   612  C C   . PRO A 1 146 ? 114.352 116.911 126.173 1.00 79.16  ? 146 PRO A C   1 
ATOM   613  O O   . PRO A 1 146 ? 113.128 117.024 126.288 1.00 79.16  ? 146 PRO A O   1 
ATOM   614  C CB  . PRO A 1 146 ? 115.859 118.579 127.306 1.00 79.16  ? 146 PRO A CB  1 
ATOM   615  C CG  . PRO A 1 146 ? 117.227 118.415 127.745 1.00 79.16  ? 146 PRO A CG  1 
ATOM   616  C CD  . PRO A 1 146 ? 117.616 117.090 127.199 1.00 79.16  ? 146 PRO A CD  1 
ATOM   617  N N   . THR A 1 147 ? 114.938 116.541 125.032 1.00 76.22  ? 147 THR A N   1 
ATOM   618  C CA  . THR A 1 147 ? 114.142 116.152 123.873 1.00 76.22  ? 147 THR A CA  1 
ATOM   619  C C   . THR A 1 147 ? 113.334 114.893 124.161 1.00 76.22  ? 147 THR A C   1 
ATOM   620  O O   . THR A 1 147 ? 112.157 114.805 123.794 1.00 76.22  ? 147 THR A O   1 
ATOM   621  C CB  . THR A 1 147 ? 115.054 115.944 122.667 1.00 76.22  ? 147 THR A CB  1 
ATOM   622  O OG1 . THR A 1 147 ? 115.745 117.164 122.381 1.00 76.22  ? 147 THR A OG1 1 
ATOM   623  C CG2 . THR A 1 147 ? 114.256 115.549 121.462 1.00 76.22  ? 147 THR A CG2 1 
ATOM   624  N N   . GLN A 1 148 ? 113.931 113.939 124.876 1.00 74.94  ? 148 GLN A N   1 
ATOM   625  C CA  . GLN A 1 148 ? 113.220 112.723 125.259 1.00 74.94  ? 148 GLN A CA  1 
ATOM   626  C C   . GLN A 1 148 ? 112.087 113.008 126.247 1.00 74.94  ? 148 GLN A C   1 
ATOM   627  O O   . GLN A 1 148 ? 110.992 112.453 126.101 1.00 74.94  ? 148 GLN A O   1 
ATOM   628  C CB  . GLN A 1 148 ? 114.212 111.716 125.833 1.00 74.94  ? 148 GLN A CB  1 
ATOM   629  C CG  . GLN A 1 148 ? 115.098 111.011 124.830 1.00 74.94  ? 148 GLN A CG  1 
ATOM   630  C CD  . GLN A 1 148 ? 114.383 109.918 124.093 1.00 74.94  ? 148 GLN A CD  1 
ATOM   631  O OE1 . GLN A 1 148 ? 113.961 110.097 122.959 1.00 74.94  ? 148 GLN A OE1 1 
ATOM   632  N NE2 . GLN A 1 148 ? 114.281 108.755 124.720 1.00 74.94  ? 148 GLN A NE2 1 
ATOM   633  N N   . TYR A 1 149 ? 112.312 113.889 127.240 1.00 73.64  ? 149 TYR A N   1 
ATOM   634  C CA  . TYR A 1 149 ? 111.228 114.236 128.166 1.00 73.64  ? 149 TYR A CA  1 
ATOM   635  C C   . TYR A 1 149 ? 110.102 114.995 127.474 1.00 73.64  ? 149 TYR A C   1 
ATOM   636  O O   . TYR A 1 149 ? 108.923 114.722 127.734 1.00 73.64  ? 149 TYR A O   1 
ATOM   637  C CB  . TYR A 1 149 ? 111.717 115.066 129.356 1.00 73.64  ? 149 TYR A CB  1 
ATOM   638  C CG  . TYR A 1 149 ? 112.386 114.302 130.475 1.00 73.64  ? 149 TYR A CG  1 
ATOM   639  C CD1 . TYR A 1 149 ? 111.693 113.326 131.177 1.00 73.64  ? 149 TYR A CD1 1 
ATOM   640  C CD2 . TYR A 1 149 ? 113.649 114.655 130.926 1.00 73.64  ? 149 TYR A CD2 1 
ATOM   641  C CE1 . TYR A 1 149 ? 112.282 112.645 132.224 1.00 73.64  ? 149 TYR A CE1 1 
ATOM   642  C CE2 . TYR A 1 149 ? 114.246 113.989 131.979 1.00 73.64  ? 149 TYR A CE2 1 
ATOM   643  C CZ  . TYR A 1 149 ? 113.558 112.985 132.622 1.00 73.64  ? 149 TYR A CZ  1 
ATOM   644  O OH  . TYR A 1 149 ? 114.151 112.325 133.672 1.00 73.64  ? 149 TYR A OH  1 
ATOM   645  N N   . ILE A 1 150 ? 110.439 115.962 126.612 1.00 69.61  ? 150 ILE A N   1 
ATOM   646  C CA  . ILE A 1 150 ? 109.415 116.717 125.895 1.00 69.61  ? 150 ILE A CA  1 
ATOM   647  C C   . ILE A 1 150 ? 108.647 115.810 124.941 1.00 69.61  ? 150 ILE A C   1 
ATOM   648  O O   . ILE A 1 150 ? 107.418 115.898 124.846 1.00 69.61  ? 150 ILE A O   1 
ATOM   649  C CB  . ILE A 1 150 ? 110.045 117.928 125.177 1.00 69.61  ? 150 ILE A CB  1 
ATOM   650  C CG1 . ILE A 1 150 ? 110.549 118.949 126.196 1.00 69.61  ? 150 ILE A CG1 1 
ATOM   651  C CG2 . ILE A 1 150 ? 109.062 118.614 124.252 1.00 69.61  ? 150 ILE A CG2 1 
ATOM   652  C CD1 . ILE A 1 150 ? 109.464 119.525 127.079 1.00 69.61  ? 150 ILE A CD1 1 
ATOM   653  N N   . LEU A 1 151 ? 109.337 114.862 124.298 1.00 67.60  ? 151 LEU A N   1 
ATOM   654  C CA  . LEU A 1 151 ? 108.668 113.950 123.377 1.00 67.60  ? 151 LEU A CA  1 
ATOM   655  C C   . LEU A 1 151 ? 107.759 112.982 124.128 1.00 67.60  ? 151 LEU A C   1 
ATOM   656  O O   . LEU A 1 151 ? 106.647 112.694 123.674 1.00 67.60  ? 151 LEU A O   1 
ATOM   657  C CB  . LEU A 1 151 ? 109.716 113.202 122.546 1.00 67.60  ? 151 LEU A CB  1 
ATOM   658  C CG  . LEU A 1 151 ? 109.371 112.526 121.213 1.00 67.60  ? 151 LEU A CG  1 
ATOM   659  C CD1 . LEU A 1 151 ? 110.603 112.429 120.339 1.00 67.60  ? 151 LEU A CD1 1 
ATOM   660  C CD2 . LEU A 1 151 ? 108.816 111.160 121.401 1.00 67.60  ? 151 LEU A CD2 1 
ATOM   661  N N   . GLY A 1 152 ? 108.191 112.507 125.298 1.00 70.76  ? 152 GLY A N   1 
ATOM   662  C CA  . GLY A 1 152 ? 107.352 111.601 126.067 1.00 70.76  ? 152 GLY A CA  1 
ATOM   663  C C   . GLY A 1 152 ? 106.135 112.278 126.671 1.00 70.76  ? 152 GLY A C   1 
ATOM   664  O O   . GLY A 1 152 ? 105.028 111.730 126.633 1.00 70.76  ? 152 GLY A O   1 
ATOM   665  N N   . LEU A 1 153 ? 106.320 113.480 127.232 1.00 69.73  ? 153 LEU A N   1 
ATOM   666  C CA  . LEU A 1 153 ? 105.191 114.242 127.758 1.00 69.73  ? 153 LEU A CA  1 
ATOM   667  C C   . LEU A 1 153 ? 104.234 114.649 126.646 1.00 69.73  ? 153 LEU A C   1 
ATOM   668  O O   . LEU A 1 153 ? 103.009 114.663 126.845 1.00 69.73  ? 153 LEU A O   1 
ATOM   669  C CB  . LEU A 1 153 ? 105.705 115.472 128.503 1.00 69.73  ? 153 LEU A CB  1 
ATOM   670  C CG  . LEU A 1 153 ? 104.690 116.357 129.218 1.00 69.73  ? 153 LEU A CG  1 
ATOM   671  C CD1 . LEU A 1 153 ? 104.006 115.577 130.318 1.00 69.73  ? 153 LEU A CD1 1 
ATOM   672  C CD2 . LEU A 1 153 ? 105.375 117.586 129.781 1.00 69.73  ? 153 LEU A CD2 1 
ATOM   673  N N   . PHE A 1 154 ? 104.769 114.927 125.456 1.00 69.53  ? 154 PHE A N   1 
ATOM   674  C CA  . PHE A 1 154 ? 103.926 115.207 124.307 1.00 69.53  ? 154 PHE A CA  1 
ATOM   675  C C   . PHE A 1 154 ? 103.175 113.966 123.850 1.00 69.53  ? 154 PHE A C   1 
ATOM   676  O O   . PHE A 1 154 ? 102.048 114.080 123.369 1.00 69.53  ? 154 PHE A O   1 
ATOM   677  C CB  . PHE A 1 154 ? 104.776 115.773 123.173 1.00 69.53  ? 154 PHE A CB  1 
ATOM   678  C CG  . PHE A 1 154 ? 103.983 116.207 121.993 1.00 69.53  ? 154 PHE A CG  1 
ATOM   679  C CD1 . PHE A 1 154 ? 103.251 117.378 122.039 1.00 69.53  ? 154 PHE A CD1 1 
ATOM   680  C CD2 . PHE A 1 154 ? 103.966 115.449 120.840 1.00 69.53  ? 154 PHE A CD2 1 
ATOM   681  C CE1 . PHE A 1 154 ? 102.512 117.786 120.955 1.00 69.53  ? 154 PHE A CE1 1 
ATOM   682  C CE2 . PHE A 1 154 ? 103.230 115.849 119.753 1.00 69.53  ? 154 PHE A CE2 1 
ATOM   683  C CZ  . PHE A 1 154 ? 102.501 117.021 119.809 1.00 69.53  ? 154 PHE A CZ  1 
ATOM   684  N N   . MET A 1 155 ? 103.760 112.776 124.016 1.00 68.23  ? 155 MET A N   1 
ATOM   685  C CA  . MET A 1 155 ? 103.009 111.560 123.719 1.00 68.23  ? 155 MET A CA  1 
ATOM   686  C C   . MET A 1 155 ? 101.911 111.302 124.734 1.00 68.23  ? 155 MET A C   1 
ATOM   687  O O   . MET A 1 155 ? 100.866 110.759 124.371 1.00 68.23  ? 155 MET A O   1 
ATOM   688  C CB  . MET A 1 155 ? 103.928 110.351 123.649 1.00 68.23  ? 155 MET A CB  1 
ATOM   689  C CG  . MET A 1 155 ? 104.736 110.351 122.412 1.00 68.23  ? 155 MET A CG  1 
ATOM   690  S SD  . MET A 1 155 ? 105.837 108.959 122.204 1.00 68.23  ? 155 MET A SD  1 
ATOM   691  C CE  . MET A 1 155 ? 104.678 107.658 121.849 1.00 68.23  ? 155 MET A CE  1 
ATOM   692  N N   . ILE A 1 156 ? 102.126 111.677 125.997 1.00 70.40  ? 156 ILE A N   1 
ATOM   693  C CA  . ILE A 1 156 ? 101.056 111.566 126.988 1.00 70.40  ? 156 ILE A CA  1 
ATOM   694  C C   . ILE A 1 156 ? 99.897  112.493 126.628 1.00 70.40  ? 156 ILE A C   1 
ATOM   695  O O   . ILE A 1 156 ? 98.724  112.086 126.635 1.00 70.40  ? 156 ILE A O   1 
ATOM   696  C CB  . ILE A 1 156 ? 101.595 111.859 128.400 1.00 70.40  ? 156 ILE A CB  1 
ATOM   697  C CG1 . ILE A 1 156 ? 102.722 110.891 128.755 1.00 70.40  ? 156 ILE A CG1 1 
ATOM   698  C CG2 . ILE A 1 156 ? 100.485 111.768 129.426 1.00 70.40  ? 156 ILE A CG2 1 
ATOM   699  C CD1 . ILE A 1 156 ? 102.322 109.449 128.722 1.00 70.40  ? 156 ILE A CD1 1 
ATOM   700  N N   . TYR A 1 157 ? 100.215 113.738 126.256 1.00 75.54  ? 157 TYR A N   1 
ATOM   701  C CA  . TYR A 1 157 ? 99.171  114.684 125.862 1.00 75.54  ? 157 TYR A CA  1 
ATOM   702  C C   . TYR A 1 157 ? 98.492  114.269 124.558 1.00 75.54  ? 157 TYR A C   1 
ATOM   703  O O   . TYR A 1 157 ? 97.277  114.447 124.398 1.00 75.54  ? 157 TYR A O   1 
ATOM   704  C CB  . TYR A 1 157 ? 99.755  116.086 125.734 1.00 75.54  ? 157 TYR A CB  1 
ATOM   705  C CG  . TYR A 1 157 ? 98.730  117.129 125.375 1.00 75.54  ? 157 TYR A CG  1 
ATOM   706  C CD1 . TYR A 1 157 ? 97.803  117.564 126.312 1.00 75.54  ? 157 TYR A CD1 1 
ATOM   707  C CD2 . TYR A 1 157 ? 98.691  117.683 124.105 1.00 75.54  ? 157 TYR A CD2 1 
ATOM   708  C CE1 . TYR A 1 157 ? 96.861  118.520 125.992 1.00 75.54  ? 157 TYR A CE1 1 
ATOM   709  C CE2 . TYR A 1 157 ? 97.757  118.640 123.776 1.00 75.54  ? 157 TYR A CE2 1 
ATOM   710  C CZ  . TYR A 1 157 ? 96.842  119.053 124.721 1.00 75.54  ? 157 TYR A CZ  1 
ATOM   711  O OH  . TYR A 1 157 ? 95.907  120.008 124.397 1.00 75.54  ? 157 TYR A OH  1 
ATOM   712  N N   . LEU A 1 158 ? 99.250  113.683 123.630 1.00 72.43  ? 158 LEU A N   1 
ATOM   713  C CA  . LEU A 1 158 ? 98.667  113.244 122.370 1.00 72.43  ? 158 LEU A CA  1 
ATOM   714  C C   . LEU A 1 158 ? 97.820  111.993 122.555 1.00 72.43  ? 158 LEU A C   1 
ATOM   715  O O   . LEU A 1 158 ? 96.824  111.820 121.851 1.00 72.43  ? 158 LEU A O   1 
ATOM   716  C CB  . LEU A 1 158 ? 99.774  113.010 121.343 1.00 72.43  ? 158 LEU A CB  1 
ATOM   717  C CG  . LEU A 1 158 ? 99.366  112.710 119.905 1.00 72.43  ? 158 LEU A CG  1 
ATOM   718  C CD1 . LEU A 1 158 ? 98.584  113.872 119.353 1.00 72.43  ? 158 LEU A CD1 1 
ATOM   719  C CD2 . LEU A 1 158 ? 100.592 112.450 119.058 1.00 72.43  ? 158 LEU A CD2 1 
ATOM   720  N N   . SER A 1 159 ? 98.175  111.130 123.510 1.00 71.57  ? 159 SER A N   1 
ATOM   721  C CA  . SER A 1 159 ? 97.316  110.003 123.850 1.00 71.57  ? 159 SER A CA  1 
ATOM   722  C C   . SER A 1 159 ? 96.040  110.459 124.533 1.00 71.57  ? 159 SER A C   1 
ATOM   723  O O   . SER A 1 159 ? 95.007  109.791 124.421 1.00 71.57  ? 159 SER A O   1 
ATOM   724  C CB  . SER A 1 159 ? 98.053  109.027 124.756 1.00 71.57  ? 159 SER A CB  1 
ATOM   725  O OG  . SER A 1 159 ? 97.181  107.994 125.172 1.00 71.57  ? 159 SER A OG  1 
ATOM   726  N N   . THR A 1 160 ? 96.099  111.569 125.267 1.00 73.62  ? 160 THR A N   1 
ATOM   727  C CA  . THR A 1 160 ? 94.870  112.135 125.813 1.00 73.62  ? 160 THR A CA  1 
ATOM   728  C C   . THR A 1 160 ? 93.984  112.709 124.708 1.00 73.62  ? 160 THR A C   1 
ATOM   729  O O   . THR A 1 160 ? 92.771  112.475 124.694 1.00 73.62  ? 160 THR A O   1 
ATOM   730  C CB  . THR A 1 160 ? 95.205  113.204 126.852 1.00 73.62  ? 160 THR A CB  1 
ATOM   731  O OG1 . THR A 1 160 ? 95.987  112.618 127.900 1.00 73.62  ? 160 THR A OG1 1 
ATOM   732  C CG2 . THR A 1 160 ? 93.937  113.793 127.455 1.00 73.62  ? 160 THR A CG2 1 
ATOM   733  N N   . GLN A 1 161 ? 94.573  113.432 123.754 1.00 78.81  ? 161 GLN A N   1 
ATOM   734  C CA  . GLN A 1 161 ? 93.782  114.203 122.799 1.00 78.81  ? 161 GLN A CA  1 
ATOM   735  C C   . GLN A 1 161 ? 93.483  113.442 121.500 1.00 78.81  ? 161 GLN A C   1 
ATOM   736  O O   . GLN A 1 161 ? 92.679  113.911 120.677 1.00 78.81  ? 161 GLN A O   1 
ATOM   737  C CB  . GLN A 1 161 ? 94.515  115.518 122.491 1.00 78.81  ? 161 GLN A CB  1 
ATOM   738  C CG  . GLN A 1 161 ? 93.636  116.664 122.010 1.00 78.81  ? 161 GLN A CG  1 
ATOM   739  C CD  . GLN A 1 161 ? 94.437  117.863 121.550 1.00 78.81  ? 161 GLN A CD  1 
ATOM   740  O OE1 . GLN A 1 161 ? 95.663  117.824 121.506 1.00 78.81  ? 161 GLN A OE1 1 
ATOM   741  N NE2 . GLN A 1 161 ? 93.740  118.939 121.194 1.00 78.81  ? 161 GLN A NE2 1 
ATOM   742  N N   . VAL A 1 162 ? 94.075  112.261 121.299 1.00 77.07  ? 162 VAL A N   1 
ATOM   743  C CA  . VAL A 1 162 ? 93.889  111.545 120.038 1.00 77.07  ? 162 VAL A CA  1 
ATOM   744  C C   . VAL A 1 162 ? 92.562  110.806 119.987 1.00 77.07  ? 162 VAL A C   1 
ATOM   745  O O   . VAL A 1 162 ? 92.203  110.254 118.940 1.00 77.07  ? 162 VAL A O   1 
ATOM   746  C CB  . VAL A 1 162 ? 95.085  110.594 119.828 1.00 77.07  ? 162 VAL A CB  1 
ATOM   747  C CG1 . VAL A 1 162 ? 94.907  109.303 120.614 1.00 77.07  ? 162 VAL A CG1 1 
ATOM   748  C CG2 . VAL A 1 162 ? 95.376  110.361 118.356 1.00 77.07  ? 162 VAL A CG2 1 
ATOM   749  N N   . ASP A 1 163 ? 91.815  110.785 121.092 1.00 89.28  ? 163 ASP A N   1 
ATOM   750  C CA  . ASP A 1 163 ? 90.451  110.276 121.054 1.00 89.28  ? 163 ASP A CA  1 
ATOM   751  C C   . ASP A 1 163 ? 89.553  111.186 120.223 1.00 89.28  ? 163 ASP A C   1 
ATOM   752  O O   . ASP A 1 163 ? 88.607  110.710 119.586 1.00 89.28  ? 163 ASP A O   1 
ATOM   753  C CB  . ASP A 1 163 ? 89.916  110.141 122.482 1.00 89.28  ? 163 ASP A CB  1 
ATOM   754  C CG  . ASP A 1 163 ? 88.707  109.223 122.582 1.00 89.28  ? 163 ASP A CG  1 
ATOM   755  O OD1 . ASP A 1 163 ? 88.297  108.636 121.562 1.00 89.28  ? 163 ASP A OD1 1 
ATOM   756  O OD2 . ASP A 1 163 ? 88.162  109.090 123.698 1.00 89.28  ? 163 ASP A OD2 1 
ATOM   757  N N   . ARG A 1 164 ? 89.842  112.490 120.200 1.00 86.71  ? 164 ARG A N   1 
ATOM   758  C CA  . ARG A 1 164 ? 89.074  113.433 119.401 1.00 86.71  ? 164 ARG A CA  1 
ATOM   759  C C   . ARG A 1 164 ? 89.805  113.940 118.166 1.00 86.71  ? 164 ARG A C   1 
ATOM   760  O O   . ARG A 1 164 ? 89.152  114.501 117.281 1.00 86.71  ? 164 ARG A O   1 
ATOM   761  C CB  . ARG A 1 164 ? 88.646  114.640 120.248 1.00 86.71  ? 164 ARG A CB  1 
ATOM   762  C CG  . ARG A 1 164 ? 89.779  115.559 120.654 1.00 86.71  ? 164 ARG A CG  1 
ATOM   763  C CD  . ARG A 1 164 ? 89.275  116.735 121.474 1.00 86.71  ? 164 ARG A CD  1 
ATOM   764  N NE  . ARG A 1 164 ? 88.704  116.320 122.753 1.00 86.71  ? 164 ARG A NE  1 
ATOM   765  C CZ  . ARG A 1 164 ? 87.406  116.361 123.042 1.00 86.71  ? 164 ARG A CZ  1 
ATOM   766  N NH1 . ARG A 1 164 ? 86.536  116.794 122.139 1.00 86.71  ? 164 ARG A NH1 1 
ATOM   767  N NH2 . ARG A 1 164 ? 86.975  115.963 124.231 1.00 86.71  ? 164 ARG A NH2 1 
ATOM   768  N N   . LEU A 1 165 ? 91.130  113.774 118.079 1.00 77.84  ? 165 LEU A N   1 
ATOM   769  C CA  . LEU A 1 165 ? 91.811  114.160 116.842 1.00 77.84  ? 165 LEU A CA  1 
ATOM   770  C C   . LEU A 1 165 ? 91.502  113.210 115.690 1.00 77.84  ? 165 LEU A C   1 
ATOM   771  O O   . LEU A 1 165 ? 91.300  113.660 114.557 1.00 77.84  ? 165 LEU A O   1 
ATOM   772  C CB  . LEU A 1 165 ? 93.317  114.274 117.061 1.00 77.84  ? 165 LEU A CB  1 
ATOM   773  C CG  . LEU A 1 165 ? 93.800  115.717 117.209 1.00 77.84  ? 165 LEU A CG  1 
ATOM   774  C CD1 . LEU A 1 165 ? 93.209  116.407 118.402 1.00 77.84  ? 165 LEU A CD1 1 
ATOM   775  C CD2 . LEU A 1 165 ? 95.312  115.751 117.292 1.00 77.84  ? 165 LEU A CD2 1 
ATOM   776  N N   . LEU A 1 166 ? 91.463  111.902 115.940 1.00 84.91  ? 166 LEU A N   1 
ATOM   777  C CA  . LEU A 1 166 ? 91.121  110.994 114.850 1.00 84.91  ? 166 LEU A CA  1 
ATOM   778  C C   . LEU A 1 166 ? 89.625  110.987 114.573 1.00 84.91  ? 166 LEU A C   1 
ATOM   779  O O   . LEU A 1 166 ? 89.210  110.931 113.411 1.00 84.91  ? 166 LEU A O   1 
ATOM   780  C CB  . LEU A 1 166 ? 91.590  109.573 115.145 1.00 84.91  ? 166 LEU A CB  1 
ATOM   781  C CG  . LEU A 1 166 ? 93.080  109.278 115.111 1.00 84.91  ? 166 LEU A CG  1 
ATOM   782  C CD1 . LEU A 1 166 ? 93.276  107.823 115.455 1.00 84.91  ? 166 LEU A CD1 1 
ATOM   783  C CD2 . LEU A 1 166 ? 93.645  109.588 113.745 1.00 84.91  ? 166 LEU A CD2 1 
ATOM   784  N N   . GLY A 1 167 ? 88.805  111.033 115.615 1.00 99.12  ? 167 GLY A N   1 
ATOM   785  C CA  . GLY A 1 167 ? 87.371  111.034 115.418 1.00 99.12  ? 167 GLY A CA  1 
ATOM   786  C C   . GLY A 1 167 ? 86.730  109.685 115.660 1.00 99.12  ? 167 GLY A C   1 
ATOM   787  O O   . GLY A 1 167 ? 85.865  109.257 114.892 1.00 99.12  ? 167 GLY A O   1 
ATOM   788  N N   . ASN A 1 168 ? 87.146  109.005 116.726 1.00 103.71 ? 168 ASN A N   1 
ATOM   789  C CA  . ASN A 1 168 ? 86.542  107.737 117.111 1.00 103.71 ? 168 ASN A CA  1 
ATOM   790  C C   . ASN A 1 168 ? 85.290  107.909 117.962 1.00 103.71 ? 168 ASN A C   1 
ATOM   791  O O   . ASN A 1 168 ? 84.745  106.908 118.441 1.00 103.71 ? 168 ASN A O   1 
ATOM   792  C CB  . ASN A 1 168 ? 87.558  106.877 117.867 1.00 103.71 ? 168 ASN A CB  1 
ATOM   793  C CG  . ASN A 1 168 ? 88.660  106.357 116.971 1.00 103.71 ? 168 ASN A CG  1 
ATOM   794  O OD1 . ASN A 1 168 ? 88.410  105.939 115.841 1.00 103.71 ? 168 ASN A OD1 1 
ATOM   795  N ND2 . ASN A 1 168 ? 89.889  106.374 117.473 1.00 103.71 ? 168 ASN A ND2 1 
ATOM   796  N N   . THR A 1 169 ? 84.828  109.140 118.165 1.00 111.37 ? 169 THR A N   1 
ATOM   797  C CA  . THR A 1 169 ? 83.649  109.431 118.973 1.00 111.37 ? 169 THR A CA  1 
ATOM   798  C C   . THR A 1 169 ? 82.564  109.990 118.061 1.00 111.37 ? 169 THR A C   1 
ATOM   799  O O   . THR A 1 169 ? 82.726  111.080 117.501 1.00 111.37 ? 169 THR A O   1 
ATOM   800  C CB  . THR A 1 169 ? 83.984  110.418 120.089 1.00 111.37 ? 169 THR A CB  1 
ATOM   801  O OG1 . THR A 1 169 ? 84.423  111.656 119.517 1.00 111.37 ? 169 THR A OG1 1 
ATOM   802  C CG2 . THR A 1 169 ? 85.085  109.862 120.976 1.00 111.37 ? 169 THR A CG2 1 
ATOM   803  N N   . ASP A 1 170 ? 81.476  109.223 117.905 1.00 117.25 ? 170 ASP A N   1 
ATOM   804  C CA  . ASP A 1 170 ? 80.256  109.622 117.187 1.00 117.25 ? 170 ASP A CA  1 
ATOM   805  C C   . ASP A 1 170 ? 80.512  109.957 115.717 1.00 117.25 ? 170 ASP A C   1 
ATOM   806  O O   . ASP A 1 170 ? 79.825  110.812 115.148 1.00 117.25 ? 170 ASP A O   1 
ATOM   807  C CB  . ASP A 1 170 ? 79.545  110.790 117.883 1.00 117.25 ? 170 ASP A CB  1 
ATOM   808  C CG  . ASP A 1 170 ? 78.921  110.388 119.205 1.00 117.25 ? 170 ASP A CG  1 
ATOM   809  O OD1 . ASP A 1 170 ? 78.540  109.207 119.350 1.00 117.25 ? 170 ASP A OD1 1 
ATOM   810  O OD2 . ASP A 1 170 ? 78.810  111.253 120.098 1.00 117.25 ? 170 ASP A OD2 1 
ATOM   811  N N   . ASP A 1 171 ? 81.505  109.282 115.118 1.00 114.30 ? 171 ASP A N   1 
ATOM   812  C CA  . ASP A 1 171 ? 81.823  109.351 113.683 1.00 114.30 ? 171 ASP A CA  1 
ATOM   813  C C   . ASP A 1 171 ? 82.158  110.772 113.228 1.00 114.30 ? 171 ASP A C   1 
ATOM   814  O O   . ASP A 1 171 ? 81.764  111.204 112.143 1.00 114.30 ? 171 ASP A O   1 
ATOM   815  C CB  . ASP A 1 171 ? 80.695  108.760 112.831 1.00 114.30 ? 171 ASP A CB  1 
ATOM   816  C CG  . ASP A 1 171 ? 80.560  107.260 113.003 1.00 114.30 ? 171 ASP A CG  1 
ATOM   817  O OD1 . ASP A 1 171 ? 81.580  106.601 113.289 1.00 114.30 ? 171 ASP A OD1 1 
ATOM   818  O OD2 . ASP A 1 171 ? 79.434  106.741 112.854 1.00 114.30 ? 171 ASP A OD2 1 
ATOM   819  N N   . ARG A 1 172 ? 82.888  111.505 114.064 1.00 105.91 ? 172 ARG A N   1 
ATOM   820  C CA  . ARG A 1 172 ? 83.300  112.853 113.705 1.00 105.91 ? 172 ARG A CA  1 
ATOM   821  C C   . ARG A 1 172 ? 84.431  112.815 112.681 1.00 105.91 ? 172 ARG A C   1 
ATOM   822  O O   . ARG A 1 172 ? 85.116  111.804 112.503 1.00 105.91 ? 172 ARG A O   1 
ATOM   823  C CB  . ARG A 1 172 ? 83.740  113.632 114.944 1.00 105.91 ? 172 ARG A CB  1 
ATOM   824  C CG  . ARG A 1 172 ? 82.610  113.967 115.899 1.00 105.91 ? 172 ARG A CG  1 
ATOM   825  C CD  . ARG A 1 172 ? 83.127  114.684 117.135 1.00 105.91 ? 172 ARG A CD  1 
ATOM   826  N NE  . ARG A 1 172 ? 83.666  116.004 116.823 1.00 105.91 ? 172 ARG A NE  1 
ATOM   827  C CZ  . ARG A 1 172 ? 84.319  116.768 117.693 1.00 105.91 ? 172 ARG A CZ  1 
ATOM   828  N NH1 . ARG A 1 172 ? 84.517  116.343 118.934 1.00 105.91 ? 172 ARG A NH1 1 
ATOM   829  N NH2 . ARG A 1 172 ? 84.774  117.957 117.324 1.00 105.91 ? 172 ARG A NH2 1 
ATOM   830  N N   . THR A 1 173 ? 84.615  113.941 111.999 1.00 86.12  ? 173 THR A N   1 
ATOM   831  C CA  . THR A 1 173 ? 85.652  114.034 110.988 1.00 86.12  ? 173 THR A CA  1 
ATOM   832  C C   . THR A 1 173 ? 87.029  114.150 111.645 1.00 86.12  ? 173 THR A C   1 
ATOM   833  O O   . THR A 1 173 ? 87.157  114.684 112.750 1.00 86.12  ? 173 THR A O   1 
ATOM   834  C CB  . THR A 1 173 ? 85.384  115.226 110.063 1.00 86.12  ? 173 THR A CB  1 
ATOM   835  O OG1 . THR A 1 173 ? 86.394  115.298 109.049 1.00 86.12  ? 173 THR A OG1 1 
ATOM   836  C CG2 . THR A 1 173 ? 85.316  116.542 110.834 1.00 86.12  ? 173 THR A CG2 1 
ATOM   837  N N   . PRO A 1 174 ? 88.068  113.596 111.016 1.00 76.56  ? 174 PRO A N   1 
ATOM   838  C CA  . PRO A 1 174 ? 89.425  113.736 111.563 1.00 76.56  ? 174 PRO A CA  1 
ATOM   839  C C   . PRO A 1 174 ? 89.924  115.163 111.406 1.00 76.56  ? 174 PRO A C   1 
ATOM   840  O O   . PRO A 1 174 ? 90.107  115.648 110.288 1.00 76.56  ? 174 PRO A O   1 
ATOM   841  C CB  . PRO A 1 174 ? 90.250  112.757 110.720 1.00 76.56  ? 174 PRO A CB  1 
ATOM   842  C CG  . PRO A 1 174 ? 89.266  111.794 110.191 1.00 76.56  ? 174 PRO A CG  1 
ATOM   843  C CD  . PRO A 1 174 ? 88.021  112.584 109.950 1.00 76.56  ? 174 PRO A CD  1 
ATOM   844  N N   . ASP A 1 175 ? 90.147  115.835 112.534 1.00 69.85  ? 175 ASP A N   1 
ATOM   845  C CA  . ASP A 1 175 ? 90.718  117.180 112.534 1.00 69.85  ? 175 ASP A CA  1 
ATOM   846  C C   . ASP A 1 175 ? 92.198  117.031 112.204 1.00 69.85  ? 175 ASP A C   1 
ATOM   847  O O   . ASP A 1 175 ? 93.064  116.962 113.078 1.00 69.85  ? 175 ASP A O   1 
ATOM   848  C CB  . ASP A 1 175 ? 90.501  117.863 113.878 1.00 69.85  ? 175 ASP A CB  1 
ATOM   849  C CG  . ASP A 1 175 ? 90.788  119.353 113.836 1.00 69.85  ? 175 ASP A CG  1 
ATOM   850  O OD1 . ASP A 1 175 ? 91.143  119.874 112.759 1.00 69.85  ? 175 ASP A OD1 1 
ATOM   851  O OD2 . ASP A 1 175 ? 90.657  120.008 114.890 1.00 69.85  ? 175 ASP A OD2 1 
ATOM   852  N N   . VAL A 1 176 ? 92.486  116.985 110.901 1.00 62.46  ? 176 VAL A N   1 
ATOM   853  C CA  . VAL A 1 176 ? 93.807  116.588 110.437 1.00 62.46  ? 176 VAL A CA  1 
ATOM   854  C C   . VAL A 1 176 ? 94.840  117.691 110.643 1.00 62.46  ? 176 VAL A C   1 
ATOM   855  O O   . VAL A 1 176 ? 96.027  117.389 110.771 1.00 62.46  ? 176 VAL A O   1 
ATOM   856  C CB  . VAL A 1 176 ? 93.709  116.140 108.962 1.00 62.46  ? 176 VAL A CB  1 
ATOM   857  C CG1 . VAL A 1 176 ? 93.443  117.318 108.048 1.00 62.46  ? 176 VAL A CG1 1 
ATOM   858  C CG2 . VAL A 1 176 ? 94.933  115.350 108.525 1.00 62.46  ? 176 VAL A CG2 1 
ATOM   859  N N   . ILE A 1 177 ? 94.413  118.955 110.745 1.00 62.21  ? 177 ILE A N   1 
ATOM   860  C CA  . ILE A 1 177 ? 95.352  120.070 110.863 1.00 62.21  ? 177 ILE A CA  1 
ATOM   861  C C   . ILE A 1 177 ? 96.017  120.067 112.233 1.00 62.21  ? 177 ILE A C   1 
ATOM   862  O O   . ILE A 1 177 ? 97.239  120.231 112.350 1.00 62.21  ? 177 ILE A O   1 
ATOM   863  C CB  . ILE A 1 177 ? 94.625  121.396 110.584 1.00 62.21  ? 177 ILE A CB  1 
ATOM   864  C CG1 . ILE A 1 177 ? 94.076  121.407 109.158 1.00 62.21  ? 177 ILE A CG1 1 
ATOM   865  C CG2 . ILE A 1 177 ? 95.548  122.581 110.799 1.00 62.21  ? 177 ILE A CG2 1 
ATOM   866  C CD1 . ILE A 1 177 ? 93.114  122.540 108.886 1.00 62.21  ? 177 ILE A CD1 1 
ATOM   867  N N   . ALA A 1 178 ? 95.225  119.863 113.288 1.00 65.85  ? 178 ALA A N   1 
ATOM   868  C CA  . ALA A 1 178 ? 95.789  119.664 114.618 1.00 65.85  ? 178 ALA A CA  1 
ATOM   869  C C   . ALA A 1 178 ? 96.595  118.375 114.680 1.00 65.85  ? 178 ALA A C   1 
ATOM   870  O O   . ALA A 1 178 ? 97.640  118.321 115.336 1.00 65.85  ? 178 ALA A O   1 
ATOM   871  C CB  . ALA A 1 178 ? 94.678  119.659 115.666 1.00 65.85  ? 178 ALA A CB  1 
ATOM   872  N N   . LEU A 1 179 ? 96.151  117.341 113.962 1.00 62.65  ? 179 LEU A N   1 
ATOM   873  C CA  . LEU A 1 179 ? 96.915  116.101 113.896 1.00 62.65  ? 179 LEU A CA  1 
ATOM   874  C C   . LEU A 1 179 ? 98.196  116.285 113.090 1.00 62.65  ? 179 LEU A C   1 
ATOM   875  O O   . LEU A 1 179 ? 99.228  115.690 113.429 1.00 62.65  ? 179 LEU A O   1 
ATOM   876  C CB  . LEU A 1 179 ? 96.045  114.998 113.300 1.00 62.65  ? 179 LEU A CB  1 
ATOM   877  C CG  . LEU A 1 179 ? 96.536  113.562 113.402 1.00 62.65  ? 179 LEU A CG  1 
ATOM   878  C CD1 . LEU A 1 179 ? 96.587  113.165 114.842 1.00 62.65  ? 179 LEU A CD1 1 
ATOM   879  C CD2 . LEU A 1 179 ? 95.606  112.645 112.655 1.00 62.65  ? 179 LEU A CD2 1 
ATOM   880  N N   . THR A 1 180 ? 98.156  117.137 112.056 1.00 59.62  ? 180 THR A N   1 
ATOM   881  C CA  . THR A 1 180 ? 99.362  117.484 111.306 1.00 59.62  ? 180 THR A CA  1 
ATOM   882  C C   . THR A 1 180 ? 100.373 118.196 112.185 1.00 59.62  ? 180 THR A C   1 
ATOM   883  O O   . THR A 1 180 ? 101.547 117.827 112.200 1.00 59.62  ? 180 THR A O   1 
ATOM   884  C CB  . THR A 1 180 ? 99.024  118.367 110.108 1.00 59.62  ? 180 THR A CB  1 
ATOM   885  O OG1 . THR A 1 180 ? 98.191  117.642 109.200 1.00 59.62  ? 180 THR A OG1 1 
ATOM   886  C CG2 . THR A 1 180 ? 100.283 118.821 109.401 1.00 59.62  ? 180 THR A CG2 1 
ATOM   887  N N   . VAL A 1 181 ? 99.939  119.221 112.927 1.00 59.26  ? 181 VAL A N   1 
ATOM   888  C CA  . VAL A 1 181 ? 100.904 119.974 113.725 1.00 59.26  ? 181 VAL A CA  1 
ATOM   889  C C   . VAL A 1 181 ? 101.385 119.141 114.911 1.00 59.26  ? 181 VAL A C   1 
ATOM   890  O O   . VAL A 1 181 ? 102.555 119.244 115.307 1.00 59.26  ? 181 VAL A O   1 
ATOM   891  C CB  . VAL A 1 181 ? 100.328 121.345 114.147 1.00 59.26  ? 181 VAL A CB  1 
ATOM   892  C CG1 . VAL A 1 181 ? 99.186  121.218 115.139 1.00 59.26  ? 181 VAL A CG1 1 
ATOM   893  C CG2 . VAL A 1 181 ? 101.423 122.251 114.690 1.00 59.26  ? 181 VAL A CG2 1 
ATOM   894  N N   . ALA A 1 182 ? 100.548 118.222 115.409 1.00 61.50  ? 182 ALA A N   1 
ATOM   895  C CA  . ALA A 1 182 ? 100.964 117.325 116.480 1.00 61.50  ? 182 ALA A CA  1 
ATOM   896  C C   . ALA A 1 182 ? 102.036 116.357 116.003 1.00 61.50  ? 182 ALA A C   1 
ATOM   897  O O   . ALA A 1 182 ? 103.132 116.307 116.571 1.00 61.50  ? 182 ALA A O   1 
ATOM   898  C CB  . ALA A 1 182 ? 99.756  116.567 117.027 1.00 61.50  ? 182 ALA A CB  1 
ATOM   899  N N   . PHE A 1 183 ? 101.760 115.606 114.933 1.00 60.86  ? 183 PHE A N   1 
ATOM   900  C CA  . PHE A 1 183 ? 102.772 114.687 114.421 1.00 60.86  ? 183 PHE A CA  1 
ATOM   901  C C   . PHE A 1 183 ? 103.939 115.393 113.738 1.00 60.86  ? 183 PHE A C   1 
ATOM   902  O O   . PHE A 1 183 ? 105.021 114.815 113.660 1.00 60.86  ? 183 PHE A O   1 
ATOM   903  C CB  . PHE A 1 183 ? 102.130 113.655 113.497 1.00 60.86  ? 183 PHE A CB  1 
ATOM   904  C CG  . PHE A 1 183 ? 101.539 112.497 114.234 1.00 60.86  ? 183 PHE A CG  1 
ATOM   905  C CD1 . PHE A 1 183 ? 102.332 111.411 114.554 1.00 60.86  ? 183 PHE A CD1 1 
ATOM   906  C CD2 . PHE A 1 183 ? 100.230 112.505 114.656 1.00 60.86  ? 183 PHE A CD2 1 
ATOM   907  C CE1 . PHE A 1 183 ? 101.817 110.343 115.252 1.00 60.86  ? 183 PHE A CE1 1 
ATOM   908  C CE2 . PHE A 1 183 ? 99.709  111.432 115.357 1.00 60.86  ? 183 PHE A CE2 1 
ATOM   909  C CZ  . PHE A 1 183 ? 100.507 110.356 115.656 1.00 60.86  ? 183 PHE A CZ  1 
ATOM   910  N N   . PHE A 1 184 ? 103.781 116.652 113.329 1.00 60.30  ? 184 PHE A N   1 
ATOM   911  C CA  . PHE A 1 184 ? 104.893 117.408 112.768 1.00 60.30  ? 184 PHE A CA  1 
ATOM   912  C C   . PHE A 1 184 ? 105.878 117.807 113.855 1.00 60.30  ? 184 PHE A C   1 
ATOM   913  O O   . PHE A 1 184 ? 107.088 117.614 113.705 1.00 60.30  ? 184 PHE A O   1 
ATOM   914  C CB  . PHE A 1 184 ? 104.359 118.643 112.044 1.00 60.30  ? 184 PHE A CB  1 
ATOM   915  C CG  . PHE A 1 184 ? 105.414 119.465 111.369 1.00 60.30  ? 184 PHE A CG  1 
ATOM   916  C CD1 . PHE A 1 184 ? 105.914 119.090 110.139 1.00 60.30  ? 184 PHE A CD1 1 
ATOM   917  C CD2 . PHE A 1 184 ? 105.897 120.621 111.960 1.00 60.30  ? 184 PHE A CD2 1 
ATOM   918  C CE1 . PHE A 1 184 ? 106.871 119.853 109.506 1.00 60.30  ? 184 PHE A CE1 1 
ATOM   919  C CE2 . PHE A 1 184 ? 106.863 121.381 111.339 1.00 60.30  ? 184 PHE A CE2 1 
ATOM   920  C CZ  . PHE A 1 184 ? 107.353 120.993 110.111 1.00 60.30  ? 184 PHE A CZ  1 
ATOM   921  N N   . LEU A 1 185 ? 105.376 118.365 114.966 1.00 64.11  ? 185 LEU A N   1 
ATOM   922  C CA  . LEU A 1 185 ? 106.245 118.678 116.096 1.00 64.11  ? 185 LEU A CA  1 
ATOM   923  C C   . LEU A 1 185 ? 106.792 117.406 116.730 1.00 64.11  ? 185 LEU A C   1 
ATOM   924  O O   . LEU A 1 185 ? 107.927 117.388 117.218 1.00 64.11  ? 185 LEU A O   1 
ATOM   925  C CB  . LEU A 1 185 ? 105.471 119.522 117.112 1.00 64.11  ? 185 LEU A CB  1 
ATOM   926  C CG  . LEU A 1 185 ? 106.186 120.260 118.245 1.00 64.11  ? 185 LEU A CG  1 
ATOM   927  C CD1 . LEU A 1 185 ? 105.434 121.538 118.546 1.00 64.11  ? 185 LEU A CD1 1 
ATOM   928  C CD2 . LEU A 1 185 ? 106.284 119.432 119.513 1.00 64.11  ? 185 LEU A CD2 1 
ATOM   929  N N   . PHE A 1 186 ? 106.019 116.326 116.667 1.00 66.95  ? 186 PHE A N   1 
ATOM   930  C CA  . PHE A 1 186 ? 106.430 115.027 117.179 1.00 66.95  ? 186 PHE A CA  1 
ATOM   931  C C   . PHE A 1 186 ? 107.569 114.432 116.353 1.00 66.95  ? 186 PHE A C   1 
ATOM   932  O O   . PHE A 1 186 ? 108.561 113.937 116.906 1.00 66.95  ? 186 PHE A O   1 
ATOM   933  C CB  . PHE A 1 186 ? 105.173 114.162 117.195 1.00 66.95  ? 186 PHE A CB  1 
ATOM   934  C CG  . PHE A 1 186 ? 105.364 112.768 117.636 1.00 66.95  ? 186 PHE A CG  1 
ATOM   935  C CD1 . PHE A 1 186 ? 105.833 112.484 118.888 1.00 66.95  ? 186 PHE A CD1 1 
ATOM   936  C CD2 . PHE A 1 186 ? 104.920 111.733 116.837 1.00 66.95  ? 186 PHE A CD2 1 
ATOM   937  C CE1 . PHE A 1 186 ? 105.964 111.189 119.289 1.00 66.95  ? 186 PHE A CE1 1 
ATOM   938  C CE2 . PHE A 1 186 ? 105.025 110.435 117.248 1.00 66.95  ? 186 PHE A CE2 1 
ATOM   939  C CZ  . PHE A 1 186 ? 105.540 110.163 118.487 1.00 66.95  ? 186 PHE A CZ  1 
ATOM   940  N N   . GLU A 1 187 ? 107.466 114.577 115.040 1.00 63.11  ? 187 GLU A N   1 
ATOM   941  C CA  . GLU A 1 187 ? 108.509 114.118 114.146 1.00 63.11  ? 187 GLU A CA  1 
ATOM   942  C C   . GLU A 1 187 ? 109.734 114.984 114.395 1.00 63.11  ? 187 GLU A C   1 
ATOM   943  O O   . GLU A 1 187 ? 110.841 114.479 114.524 1.00 63.11  ? 187 GLU A O   1 
ATOM   944  C CB  . GLU A 1 187 ? 108.067 114.287 112.702 1.00 63.11  ? 187 GLU A CB  1 
ATOM   945  C CG  . GLU A 1 187 ? 108.828 113.428 111.720 1.00 63.11  ? 187 GLU A CG  1 
ATOM   946  C CD  . GLU A 1 187 ? 108.513 111.972 111.916 1.00 63.11  ? 187 GLU A CD  1 
ATOM   947  O OE1 . GLU A 1 187 ? 107.898 111.654 112.950 1.00 63.11  ? 187 GLU A OE1 1 
ATOM   948  O OE2 . GLU A 1 187 ? 108.871 111.155 111.048 1.00 63.11  ? 187 GLU A OE2 1 
ATOM   949  N N   . PHE A 1 188 ? 109.520 116.296 114.470 1.00 64.52  ? 188 PHE A N   1 
ATOM   950  C CA  . PHE A 1 188 ? 110.602 117.251 114.699 1.00 64.52  ? 188 PHE A CA  1 
ATOM   951  C C   . PHE A 1 188 ? 111.419 116.875 115.929 1.00 64.52  ? 188 PHE A C   1 
ATOM   952  O O   . PHE A 1 188 ? 112.660 116.885 115.900 1.00 64.52  ? 188 PHE A O   1 
ATOM   953  C CB  . PHE A 1 188 ? 110.010 118.653 114.855 1.00 64.52  ? 188 PHE A CB  1 
ATOM   954  C CG  . PHE A 1 188 ? 111.018 119.715 115.172 1.00 64.52  ? 188 PHE A CG  1 
ATOM   955  C CD1 . PHE A 1 188 ? 111.825 120.236 114.182 1.00 64.52  ? 188 PHE A CD1 1 
ATOM   956  C CD2 . PHE A 1 188 ? 111.142 120.206 116.463 1.00 64.52  ? 188 PHE A CD2 1 
ATOM   957  C CE1 . PHE A 1 188 ? 112.751 121.219 114.472 1.00 64.52  ? 188 PHE A CE1 1 
ATOM   958  C CE2 . PHE A 1 188 ? 112.065 121.185 116.763 1.00 64.52  ? 188 PHE A CE2 1 
ATOM   959  C CZ  . PHE A 1 188 ? 112.870 121.694 115.767 1.00 64.52  ? 188 PHE A CZ  1 
ATOM   960  N N   . LEU A 1 189 ? 110.728 116.534 117.020 1.00 65.62  ? 189 LEU A N   1 
ATOM   961  C CA  . LEU A 1 189 ? 111.408 116.077 118.225 1.00 65.62  ? 189 LEU A CA  1 
ATOM   962  C C   . LEU A 1 189 ? 112.122 114.751 117.990 1.00 65.62  ? 189 LEU A C   1 
ATOM   963  O O   . LEU A 1 189 ? 113.229 114.541 118.500 1.00 65.62  ? 189 LEU A O   1 
ATOM   964  C CB  . LEU A 1 189 ? 110.414 115.963 119.376 1.00 65.62  ? 189 LEU A CB  1 
ATOM   965  C CG  . LEU A 1 189 ? 109.817 117.258 119.909 1.00 65.62  ? 189 LEU A CG  1 
ATOM   966  C CD1 . LEU A 1 189 ? 108.755 116.941 120.931 1.00 65.62  ? 189 LEU A CD1 1 
ATOM   967  C CD2 . LEU A 1 189 ? 110.896 118.131 120.507 1.00 65.62  ? 189 LEU A CD2 1 
ATOM   968  N N   . ALA A 1 190 ? 111.525 113.864 117.186 1.00 66.07  ? 190 ALA A N   1 
ATOM   969  C CA  . ALA A 1 190 ? 112.195 112.609 116.846 1.00 66.07  ? 190 ALA A CA  1 
ATOM   970  C C   . ALA A 1 190 ? 113.464 112.847 116.033 1.00 66.07  ? 190 ALA A C   1 
ATOM   971  O O   . ALA A 1 190 ? 114.485 112.194 116.262 1.00 66.07  ? 190 ALA A O   1 
ATOM   972  C CB  . ALA A 1 190 ? 111.245 111.698 116.080 1.00 66.07  ? 190 ALA A CB  1 
ATOM   973  N N   . ALA A 1 191 ? 113.432 113.807 115.110 1.00 66.56  ? 191 ALA A N   1 
ATOM   974  C CA  . ALA A 1 191 ? 114.599 114.069 114.276 1.00 66.56  ? 191 ALA A CA  1 
ATOM   975  C C   . ALA A 1 191 ? 115.726 114.703 115.078 1.00 66.56  ? 191 ALA A C   1 
ATOM   976  O O   . ALA A 1 191 ? 116.893 114.319 114.924 1.00 66.56  ? 191 ALA A O   1 
ATOM   977  C CB  . ALA A 1 191 ? 114.217 114.959 113.098 1.00 66.56  ? 191 ALA A CB  1 
ATOM   978  N N   . THR A 1 192 ? 115.405 115.660 115.954 1.00 69.51  ? 192 THR A N   1 
ATOM   979  C CA  . THR A 1 192 ? 116.474 116.234 116.766 1.00 69.51  ? 192 THR A CA  1 
ATOM   980  C C   . THR A 1 192 ? 116.982 115.259 117.826 1.00 69.51  ? 192 THR A C   1 
ATOM   981  O O   . THR A 1 192 ? 118.160 115.326 118.196 1.00 69.51  ? 192 THR A O   1 
ATOM   982  C CB  . THR A 1 192 ? 116.038 117.562 117.395 1.00 69.51  ? 192 THR A CB  1 
ATOM   983  O OG1 . THR A 1 192 ? 117.141 118.142 118.096 1.00 69.51  ? 192 THR A OG1 1 
ATOM   984  C CG2 . THR A 1 192 ? 114.898 117.387 118.346 1.00 69.51  ? 192 THR A CG2 1 
ATOM   985  N N   . GLN A 1 193 ? 116.162 114.293 118.250 1.00 72.17  ? 193 GLN A N   1 
ATOM   986  C CA  . GLN A 1 193 ? 116.685 113.243 119.114 1.00 72.17  ? 193 GLN A CA  1 
ATOM   987  C C   . GLN A 1 193 ? 117.581 112.282 118.342 1.00 72.17  ? 193 GLN A C   1 
ATOM   988  O O   . GLN A 1 193 ? 118.553 111.759 118.903 1.00 72.17  ? 193 GLN A O   1 
ATOM   989  C CB  . GLN A 1 193 ? 115.527 112.516 119.785 1.00 72.17  ? 193 GLN A CB  1 
ATOM   990  C CG  . GLN A 1 193 ? 115.932 111.615 120.912 1.00 72.17  ? 193 GLN A CG  1 
ATOM   991  C CD  . GLN A 1 193 ? 115.944 110.165 120.530 1.00 72.17  ? 193 GLN A CD  1 
ATOM   992  O OE1 . GLN A 1 193 ? 115.187 109.740 119.671 1.00 72.17  ? 193 GLN A OE1 1 
ATOM   993  N NE2 . GLN A 1 193 ? 116.763 109.381 121.210 1.00 72.17  ? 193 GLN A NE2 1 
ATOM   994  N N   . ASP A 1 194 ? 117.299 112.074 117.051 1.00 74.06  ? 194 ASP A N   1 
ATOM   995  C CA  . ASP A 1 194 ? 118.208 111.301 116.207 1.00 74.06  ? 194 ASP A CA  1 
ATOM   996  C C   . ASP A 1 194 ? 119.546 112.009 116.051 1.00 74.06  ? 194 ASP A C   1 
ATOM   997  O O   . ASP A 1 194 ? 120.596 111.359 116.035 1.00 74.06  ? 194 ASP A O   1 
ATOM   998  C CB  . ASP A 1 194 ? 117.592 111.061 114.831 1.00 74.06  ? 194 ASP A CB  1 
ATOM   999  C CG  . ASP A 1 194 ? 118.300 109.964 114.054 1.00 74.06  ? 194 ASP A CG  1 
ATOM   1000 O OD1 . ASP A 1 194 ? 119.195 109.298 114.610 1.00 74.06  ? 194 ASP A OD1 1 
ATOM   1001 O OD2 . ASP A 1 194 ? 117.974 109.777 112.867 1.00 74.06  ? 194 ASP A OD2 1 
ATOM   1002 N N   . ILE A 1 195 ? 119.525 113.340 115.927 1.00 75.87  ? 195 ILE A N   1 
ATOM   1003 C CA  . ILE A 1 195 ? 120.778 114.093 115.853 1.00 75.87  ? 195 ILE A CA  1 
ATOM   1004 C C   . ILE A 1 195 ? 121.545 113.977 117.165 1.00 75.87  ? 195 ILE A C   1 
ATOM   1005 O O   . ILE A 1 195 ? 122.774 113.816 117.171 1.00 75.87  ? 195 ILE A O   1 
ATOM   1006 C CB  . ILE A 1 195 ? 120.516 115.566 115.509 1.00 75.87  ? 195 ILE A CB  1 
ATOM   1007 C CG1 . ILE A 1 195 ? 119.741 115.696 114.216 1.00 75.87  ? 195 ILE A CG1 1 
ATOM   1008 C CG2 . ILE A 1 195 ? 121.824 116.293 115.300 1.00 75.87  ? 195 ILE A CG2 1 
ATOM   1009 C CD1 . ILE A 1 195 ? 119.144 117.050 114.080 1.00 75.87  ? 195 ILE A CD1 1 
ATOM   1010 N N   . ALA A 1 196 ? 120.824 114.036 118.291 1.00 80.83  ? 196 ALA A N   1 
ATOM   1011 C CA  . ALA A 1 196 ? 121.460 113.929 119.601 1.00 80.83  ? 196 ALA A CA  1 
ATOM   1012 C C   . ALA A 1 196 ? 122.100 112.561 119.809 1.00 80.83  ? 196 ALA A C   1 
ATOM   1013 O O   . ALA A 1 196 ? 123.180 112.461 120.400 1.00 80.83  ? 196 ALA A O   1 
ATOM   1014 C CB  . ALA A 1 196 ? 120.441 114.219 120.702 1.00 80.83  ? 196 ALA A CB  1 
ATOM   1015 N N   . VAL A 1 197 ? 121.476 111.498 119.299 1.00 80.39  ? 197 VAL A N   1 
ATOM   1016 C CA  . VAL A 1 197 ? 122.088 110.180 119.456 1.00 80.39  ? 197 VAL A CA  1 
ATOM   1017 C C   . VAL A 1 197 ? 123.228 109.980 118.454 1.00 80.39  ? 197 VAL A C   1 
ATOM   1018 O O   . VAL A 1 197 ? 124.271 109.412 118.800 1.00 80.39  ? 197 VAL A O   1 
ATOM   1019 C CB  . VAL A 1 197 ? 121.023 109.073 119.356 1.00 80.39  ? 197 VAL A CB  1 
ATOM   1020 C CG1 . VAL A 1 197 ? 121.643 107.708 119.529 1.00 80.39  ? 197 VAL A CG1 1 
ATOM   1021 C CG2 . VAL A 1 197 ? 120.007 109.259 120.428 1.00 80.39  ? 197 VAL A CG2 1 
ATOM   1022 N N   . ASP A 1 198 ? 123.073 110.467 117.212 1.00 80.99  ? 198 ASP A N   1 
ATOM   1023 C CA  . ASP A 1 198 ? 124.130 110.330 116.207 1.00 80.99  ? 198 ASP A CA  1 
ATOM   1024 C C   . ASP A 1 198 ? 125.375 111.127 116.568 1.00 80.99  ? 198 ASP A C   1 
ATOM   1025 O O   . ASP A 1 198 ? 126.479 110.769 116.145 1.00 80.99  ? 198 ASP A O   1 
ATOM   1026 C CB  . ASP A 1 198 ? 123.625 110.763 114.830 1.00 80.99  ? 198 ASP A CB  1 
ATOM   1027 C CG  . ASP A 1 198 ? 122.726 109.733 114.185 1.00 80.99  ? 198 ASP A CG  1 
ATOM   1028 O OD1 . ASP A 1 198 ? 122.926 108.529 114.438 1.00 80.99  ? 198 ASP A OD1 1 
ATOM   1029 O OD2 . ASP A 1 198 ? 121.826 110.126 113.416 1.00 80.99  ? 198 ASP A OD2 1 
ATOM   1030 N N   . GLY A 1 199 ? 125.223 112.209 117.332 1.00 91.87  ? 199 GLY A N   1 
ATOM   1031 C CA  . GLY A 1 199 ? 126.383 112.823 117.949 1.00 91.87  ? 199 GLY A CA  1 
ATOM   1032 C C   . GLY A 1 199 ? 126.823 112.102 119.204 1.00 91.87  ? 199 GLY A C   1 
ATOM   1033 O O   . GLY A 1 199 ? 128.015 112.082 119.525 1.00 91.87  ? 199 GLY A O   1 
ATOM   1034 N N   . TRP A 1 200 ? 125.874 111.506 119.930 1.00 93.59  ? 200 TRP A N   1 
ATOM   1035 C CA  . TRP A 1 200 ? 126.175 110.796 121.166 1.00 93.59  ? 200 TRP A CA  1 
ATOM   1036 C C   . TRP A 1 200 ? 126.835 109.451 120.906 1.00 93.59  ? 200 TRP A C   1 
ATOM   1037 O O   . TRP A 1 200 ? 127.497 108.915 121.800 1.00 93.59  ? 200 TRP A O   1 
ATOM   1038 C CB  . TRP A 1 200 ? 124.880 110.613 121.961 1.00 93.59  ? 200 TRP A CB  1 
ATOM   1039 C CG  . TRP A 1 200 ? 125.032 110.042 123.331 1.00 93.59  ? 200 TRP A CG  1 
ATOM   1040 C CD1 . TRP A 1 200 ? 125.652 110.622 124.393 1.00 93.59  ? 200 TRP A CD1 1 
ATOM   1041 C CD2 . TRP A 1 200 ? 124.530 108.786 123.797 1.00 93.59  ? 200 TRP A CD2 1 
ATOM   1042 N NE1 . TRP A 1 200 ? 125.578 109.804 125.490 1.00 93.59  ? 200 TRP A NE1 1 
ATOM   1043 C CE2 . TRP A 1 200 ? 124.893 108.669 125.150 1.00 93.59  ? 200 TRP A CE2 1 
ATOM   1044 C CE3 . TRP A 1 200 ? 123.814 107.746 123.198 1.00 93.59  ? 200 TRP A CE3 1 
ATOM   1045 C CZ2 . TRP A 1 200 ? 124.566 107.555 125.916 1.00 93.59  ? 200 TRP A CZ2 1 
ATOM   1046 C CZ3 . TRP A 1 200 ? 123.493 106.640 123.959 1.00 93.59  ? 200 TRP A CZ3 1 
ATOM   1047 C CH2 . TRP A 1 200 ? 123.866 106.553 125.304 1.00 93.59  ? 200 TRP A CH2 1 
ATOM   1048 N N   . ALA A 1 201 ? 126.673 108.899 119.702 1.00 96.20  ? 201 ALA A N   1 
ATOM   1049 C CA  . ALA A 1 201 ? 127.273 107.609 119.385 1.00 96.20  ? 201 ALA A CA  1 
ATOM   1050 C C   . ALA A 1 201 ? 128.778 107.716 119.194 1.00 96.20  ? 201 ALA A C   1 
ATOM   1051 O O   . ALA A 1 201 ? 129.499 106.738 119.413 1.00 96.20  ? 201 ALA A O   1 
ATOM   1052 C CB  . ALA A 1 201 ? 126.628 107.024 118.130 1.00 96.20  ? 201 ALA A CB  1 
ATOM   1053 N N   . LEU A 1 202 ? 129.272 108.884 118.789 1.00 99.19  ? 202 LEU A N   1 
ATOM   1054 C CA  . LEU A 1 202 ? 130.696 109.038 118.525 1.00 99.19  ? 202 LEU A CA  1 
ATOM   1055 C C   . LEU A 1 202 ? 131.519 109.210 119.794 1.00 99.19  ? 202 LEU A C   1 
ATOM   1056 O O   . LEU A 1 202 ? 132.742 109.037 119.749 1.00 99.19  ? 202 LEU A O   1 
ATOM   1057 C CB  . LEU A 1 202 ? 130.937 110.228 117.589 1.00 99.19  ? 202 LEU A CB  1 
ATOM   1058 C CG  . LEU A 1 202 ? 130.933 110.025 116.066 1.00 99.19  ? 202 LEU A CG  1 
ATOM   1059 C CD1 . LEU A 1 202 ? 132.072 109.106 115.654 1.00 99.19  ? 202 LEU A CD1 1 
ATOM   1060 C CD2 . LEU A 1 202 ? 129.605 109.510 115.523 1.00 99.19  ? 202 LEU A CD2 1 
ATOM   1061 N N   . THR A 1 203 ? 130.886 109.540 120.922 1.00 103.10 ? 203 THR A N   1 
ATOM   1062 C CA  . THR A 1 203 ? 131.604 109.802 122.161 1.00 103.10 ? 203 THR A CA  1 
ATOM   1063 C C   . THR A 1 203 ? 131.319 108.809 123.277 1.00 103.10 ? 203 THR A C   1 
ATOM   1064 O O   . THR A 1 203 ? 132.156 108.671 124.175 1.00 103.10 ? 203 THR A O   1 
ATOM   1065 C CB  . THR A 1 203 ? 131.284 111.213 122.682 1.00 103.10 ? 203 THR A CB  1 
ATOM   1066 O OG1 . THR A 1 203 ? 129.885 111.312 122.972 1.00 103.10 ? 203 THR A OG1 1 
ATOM   1067 C CG2 . THR A 1 203 ? 131.660 112.265 121.650 1.00 103.10 ? 203 THR A CG2 1 
ATOM   1068 N N   . MET A 1 204 ? 130.178 108.121 123.255 1.00 107.72 ? 204 MET A N   1 
ATOM   1069 C CA  . MET A 1 204 ? 129.845 107.211 124.346 1.00 107.72 ? 204 MET A CA  1 
ATOM   1070 C C   . MET A 1 204 ? 130.598 105.892 124.224 1.00 107.72 ? 204 MET A C   1 
ATOM   1071 O O   . MET A 1 204 ? 131.172 105.405 125.203 1.00 107.72 ? 204 MET A O   1 
ATOM   1072 C CB  . MET A 1 204 ? 128.338 106.966 124.384 1.00 107.72 ? 204 MET A CB  1 
ATOM   1073 C CG  . MET A 1 204 ? 127.889 106.113 125.551 1.00 107.72 ? 204 MET A CG  1 
ATOM   1074 S SD  . MET A 1 204 ? 128.177 106.870 127.161 1.00 107.72 ? 204 MET A SD  1 
ATOM   1075 C CE  . MET A 1 204 ? 128.220 105.419 128.212 1.00 107.72 ? 204 MET A CE  1 
ATOM   1076 N N   . LEU A 1 205 ? 130.603 105.300 123.037 1.00 107.29 ? 205 LEU A N   1 
ATOM   1077 C CA  . LEU A 1 205 ? 131.350 104.079 122.780 1.00 107.29 ? 205 LEU A CA  1 
ATOM   1078 C C   . LEU A 1 205 ? 132.722 104.402 122.192 1.00 107.29 ? 205 LEU A C   1 
ATOM   1079 O O   . LEU A 1 205 ? 133.020 105.540 121.825 1.00 107.29 ? 205 LEU A O   1 
ATOM   1080 C CB  . LEU A 1 205 ? 130.542 103.145 121.871 1.00 107.29 ? 205 LEU A CB  1 
ATOM   1081 C CG  . LEU A 1 205 ? 129.916 103.668 120.573 1.00 107.29 ? 205 LEU A CG  1 
ATOM   1082 C CD1 . LEU A 1 205 ? 130.847 103.621 119.373 1.00 107.29 ? 205 LEU A CD1 1 
ATOM   1083 C CD2 . LEU A 1 205 ? 128.634 102.907 120.277 1.00 107.29 ? 205 LEU A CD2 1 
ATOM   1084 N N   . SER A 1 206 ? 133.562 103.375 122.109 1.00 108.94 ? 206 SER A N   1 
ATOM   1085 C CA  . SER A 1 206 ? 134.953 103.554 121.725 1.00 108.94 ? 206 SER A CA  1 
ATOM   1086 C C   . SER A 1 206 ? 135.088 103.758 120.217 1.00 108.94 ? 206 SER A C   1 
ATOM   1087 O O   . SER A 1 206 ? 134.155 103.544 119.441 1.00 108.94 ? 206 SER A O   1 
ATOM   1088 C CB  . SER A 1 206 ? 135.790 102.356 122.169 1.00 108.94 ? 206 SER A CB  1 
ATOM   1089 O OG  . SER A 1 206 ? 137.142 102.507 121.775 1.00 108.94 ? 206 SER A OG  1 
ATOM   1090 N N   . ARG A 1 207 ? 136.288 104.179 119.808 1.00 109.27 ? 207 ARG A N   1 
ATOM   1091 C CA  . ARG A 1 207 ? 136.580 104.398 118.396 1.00 109.27 ? 207 ARG A CA  1 
ATOM   1092 C C   . ARG A 1 207 ? 136.660 103.088 117.618 1.00 109.27 ? 207 ARG A C   1 
ATOM   1093 O O   . ARG A 1 207 ? 136.406 103.080 116.408 1.00 109.27 ? 207 ARG A O   1 
ATOM   1094 C CB  . ARG A 1 207 ? 137.884 105.196 118.265 1.00 109.27 ? 207 ARG A CB  1 
ATOM   1095 C CG  . ARG A 1 207 ? 138.224 105.685 116.861 1.00 109.27 ? 207 ARG A CG  1 
ATOM   1096 C CD  . ARG A 1 207 ? 139.509 106.498 116.841 1.00 109.27 ? 207 ARG A CD  1 
ATOM   1097 N NE  . ARG A 1 207 ? 139.368 107.766 117.551 1.00 109.27 ? 207 ARG A NE  1 
ATOM   1098 C CZ  . ARG A 1 207 ? 138.893 108.880 117.004 1.00 109.27 ? 207 ARG A CZ  1 
ATOM   1099 N NH1 . ARG A 1 207 ? 138.514 108.890 115.733 1.00 109.27 ? 207 ARG A NH1 1 
ATOM   1100 N NH2 . ARG A 1 207 ? 138.800 109.988 117.726 1.00 109.27 ? 207 ARG A NH2 1 
ATOM   1101 N N   . GLU A 1 208 ? 136.972 101.979 118.294 1.00 106.96 ? 208 GLU A N   1 
ATOM   1102 C CA  . GLU A 1 208 ? 137.073 100.688 117.621 1.00 106.96 ? 208 GLU A CA  1 
ATOM   1103 C C   . GLU A 1 208 ? 135.709 100.187 117.153 1.00 106.96 ? 208 GLU A C   1 
ATOM   1104 O O   . GLU A 1 208 ? 135.621 99.485  116.138 1.00 106.96 ? 208 GLU A O   1 
ATOM   1105 C CB  . GLU A 1 208 ? 137.735 99.675  118.559 1.00 106.96 ? 208 GLU A CB  1 
ATOM   1106 C CG  . GLU A 1 208 ? 138.065 98.325  117.937 1.00 106.96 ? 208 GLU A CG  1 
ATOM   1107 C CD  . GLU A 1 208 ? 138.758 97.391  118.908 1.00 106.96 ? 208 GLU A CD  1 
ATOM   1108 O OE1 . GLU A 1 208 ? 138.961 97.788  120.074 1.00 106.96 ? 208 GLU A OE1 1 
ATOM   1109 O OE2 . GLU A 1 208 ? 139.101 96.259  118.506 1.00 106.96 ? 208 GLU A OE2 1 
ATOM   1110 N N   . ASN A 1 209 ? 134.638 100.562 117.849 1.00 108.77 ? 209 ASN A N   1 
ATOM   1111 C CA  . ASN A 1 209 ? 133.285 100.113 117.524 1.00 108.77 ? 209 ASN A CA  1 
ATOM   1112 C C   . ASN A 1 209 ? 132.467 101.197 116.832 1.00 108.77 ? 209 ASN A C   1 
ATOM   1113 O O   . ASN A 1 209 ? 131.256 101.294 117.050 1.00 108.77 ? 209 ASN A O   1 
ATOM   1114 C CB  . ASN A 1 209 ? 132.573 99.637  118.786 1.00 108.77 ? 209 ASN A CB  1 
ATOM   1115 C CG  . ASN A 1 209 ? 133.160 98.356  119.340 1.00 108.77 ? 209 ASN A CG  1 
ATOM   1116 O OD1 . ASN A 1 209 ? 133.485 97.435  118.593 1.00 108.77 ? 209 ASN A OD1 1 
ATOM   1117 N ND2 . ASN A 1 209 ? 133.299 98.292  120.658 1.00 108.77 ? 209 ASN A ND2 1 
ATOM   1118 N N   . VAL A 1 210 ? 133.090 102.016 115.983 1.00 106.39 ? 210 VAL A N   1 
ATOM   1119 C CA  . VAL A 1 210 ? 132.376 103.149 115.398 1.00 106.39 ? 210 VAL A CA  1 
ATOM   1120 C C   . VAL A 1 210 ? 131.434 102.701 114.273 1.00 106.39 ? 210 VAL A C   1 
ATOM   1121 O O   . VAL A 1 210 ? 130.371 103.301 114.077 1.00 106.39 ? 210 VAL A O   1 
ATOM   1122 C CB  . VAL A 1 210 ? 133.387 104.226 114.948 1.00 106.39 ? 210 VAL A CB  1 
ATOM   1123 C CG1 . VAL A 1 210 ? 134.305 103.729 113.829 1.00 106.39 ? 210 VAL A CG1 1 
ATOM   1124 C CG2 . VAL A 1 210 ? 132.687 105.525 114.556 1.00 106.39 ? 210 VAL A CG2 1 
ATOM   1125 N N   . GLY A 1 211 ? 131.768 101.628 113.549 1.00 103.64 ? 211 GLY A N   1 
ATOM   1126 C CA  . GLY A 1 211 ? 130.853 101.111 112.547 1.00 103.64 ? 211 GLY A CA  1 
ATOM   1127 C C   . GLY A 1 211 ? 129.719 100.312 113.146 1.00 103.64 ? 211 GLY A C   1 
ATOM   1128 O O   . GLY A 1 211 ? 128.640 100.206 112.543 1.00 103.64 ? 211 GLY A O   1 
ATOM   1129 N N   . TYR A 1 212 ? 129.943 99.744  114.336 1.00 106.27 ? 212 TYR A N   1 
ATOM   1130 C CA  . TYR A 1 212 ? 128.872 99.073  115.060 1.00 106.27 ? 212 TYR A CA  1 
ATOM   1131 C C   . TYR A 1 212 ? 127.788 100.052 115.478 1.00 106.27 ? 212 TYR A C   1 
ATOM   1132 O O   . TYR A 1 212 ? 126.612 99.684  115.509 1.00 106.27 ? 212 TYR A O   1 
ATOM   1133 C CB  . TYR A 1 212 ? 129.433 98.336  116.276 1.00 106.27 ? 212 TYR A CB  1 
ATOM   1134 C CG  . TYR A 1 212 ? 130.288 97.144  115.910 1.00 106.27 ? 212 TYR A CG  1 
ATOM   1135 C CD1 . TYR A 1 212 ? 129.707 95.928  115.566 1.00 106.27 ? 212 TYR A CD1 1 
ATOM   1136 C CD2 . TYR A 1 212 ? 131.674 97.237  115.897 1.00 106.27 ? 212 TYR A CD2 1 
ATOM   1137 C CE1 . TYR A 1 212 ? 130.486 94.833  115.225 1.00 106.27 ? 212 TYR A CE1 1 
ATOM   1138 C CE2 . TYR A 1 212 ? 132.462 96.149  115.558 1.00 106.27 ? 212 TYR A CE2 1 
ATOM   1139 C CZ  . TYR A 1 212 ? 131.862 94.951  115.223 1.00 106.27 ? 212 TYR A CZ  1 
ATOM   1140 O OH  . TYR A 1 212 ? 132.642 93.869  114.886 1.00 106.27 ? 212 TYR A OH  1 
ATOM   1141 N N   . ALA A 1 213 ? 128.154 101.310 115.742 1.00 98.15  ? 213 ALA A N   1 
ATOM   1142 C CA  . ALA A 1 213 ? 127.153 102.339 116.008 1.00 98.15  ? 213 ALA A CA  1 
ATOM   1143 C C   . ALA A 1 213 ? 126.317 102.640 114.769 1.00 98.15  ? 213 ALA A C   1 
ATOM   1144 O O   . ALA A 1 213 ? 125.113 102.887 114.877 1.00 98.15  ? 213 ALA A O   1 
ATOM   1145 C CB  . ALA A 1 213 ? 127.828 103.610 116.516 1.00 98.15  ? 213 ALA A CB  1 
ATOM   1146 N N   . SER A 1 214 ? 126.924 102.580 113.581 1.00 94.36  ? 214 SER A N   1 
ATOM   1147 C CA  . SER A 1 214 ? 126.183 102.858 112.351 1.00 94.36  ? 214 SER A CA  1 
ATOM   1148 C C   . SER A 1 214 ? 125.223 101.721 112.013 1.00 94.36  ? 214 SER A C   1 
ATOM   1149 O O   . SER A 1 214 ? 124.045 101.958 111.702 1.00 94.36  ? 214 SER A O   1 
ATOM   1150 C CB  . SER A 1 214 ? 127.157 103.103 111.199 1.00 94.36  ? 214 SER A CB  1 
ATOM   1151 O OG  . SER A 1 214 ? 126.463 103.354 109.990 1.00 94.36  ? 214 SER A OG  1 
ATOM   1152 N N   . THR A 1 215 ? 125.697 100.473 112.083 1.00 91.39  ? 215 THR A N   1 
ATOM   1153 C CA  . THR A 1 215 ? 124.778 99.364  111.838 1.00 91.39  ? 215 THR A CA  1 
ATOM   1154 C C   . THR A 1 215 ? 123.777 99.187  112.976 1.00 91.39  ? 215 THR A C   1 
ATOM   1155 O O   . THR A 1 215 ? 122.683 98.660  112.747 1.00 91.39  ? 215 THR A O   1 
ATOM   1156 C CB  . THR A 1 215 ? 125.544 98.059  111.577 1.00 91.39  ? 215 THR A CB  1 
ATOM   1157 O OG1 . THR A 1 215 ? 124.624 97.037  111.174 1.00 91.39  ? 215 THR A OG1 1 
ATOM   1158 C CG2 . THR A 1 215 ? 126.298 97.593  112.810 1.00 91.39  ? 215 THR A CG2 1 
ATOM   1159 N N   . CYS A 1 216 ? 124.089 99.692  114.173 1.00 87.96  ? 216 CYS A N   1 
ATOM   1160 C CA  . CYS A 1 216 ? 123.133 99.677  115.266 1.00 87.96  ? 216 CYS A CA  1 
ATOM   1161 C C   . CYS A 1 216 ? 122.061 100.739 115.070 1.00 87.96  ? 216 CYS A C   1 
ATOM   1162 O O   . CYS A 1 216 ? 120.898 100.505 115.407 1.00 87.96  ? 216 CYS A O   1 
ATOM   1163 C CB  . CYS A 1 216 ? 123.864 99.879  116.590 1.00 87.96  ? 216 CYS A CB  1 
ATOM   1164 S SG  . CYS A 1 216 ? 122.832 99.659  118.029 1.00 87.96  ? 216 CYS A SG  1 
ATOM   1165 N N   . ASN A 1 217 ? 122.445 101.903 114.532 1.00 84.39  ? 217 ASN A N   1 
ATOM   1166 C CA  . ASN A 1 217 ? 121.485 102.891 114.043 1.00 84.39  ? 217 ASN A CA  1 
ATOM   1167 C C   . ASN A 1 217 ? 120.551 102.277 113.012 1.00 84.39  ? 217 ASN A C   1 
ATOM   1168 O O   . ASN A 1 217 ? 119.334 102.470 113.085 1.00 84.39  ? 217 ASN A O   1 
ATOM   1169 C CB  . ASN A 1 217 ? 122.248 104.089 113.456 1.00 84.39  ? 217 ASN A CB  1 
ATOM   1170 C CG  . ASN A 1 217 ? 121.349 105.271 113.051 1.00 84.39  ? 217 ASN A CG  1 
ATOM   1171 O OD1 . ASN A 1 217 ? 120.123 105.236 113.154 1.00 84.39  ? 217 ASN A OD1 1 
ATOM   1172 N ND2 . ASN A 1 217 ? 121.987 106.335 112.579 1.00 84.39  ? 217 ASN A ND2 1 
ATOM   1173 N N   . SER A 1 218 ? 121.105 101.510 112.068 1.00 82.22  ? 218 SER A N   1 
ATOM   1174 C CA  . SER A 1 218 ? 120.285 100.900 111.022 1.00 82.22  ? 218 SER A CA  1 
ATOM   1175 C C   . SER A 1 218 ? 119.292 99.892  111.598 1.00 82.22  ? 218 SER A C   1 
ATOM   1176 O O   . SER A 1 218 ? 118.082 99.982  111.341 1.00 82.22  ? 218 SER A O   1 
ATOM   1177 C CB  . SER A 1 218 ? 121.183 100.238 109.980 1.00 82.22  ? 218 SER A CB  1 
ATOM   1178 O OG  . SER A 1 218 ? 121.979 101.202 109.314 1.00 82.22  ? 218 SER A OG  1 
ATOM   1179 N N   . VAL A 1 219 ? 119.776 98.957  112.425 1.00 79.41  ? 219 VAL A N   1 
ATOM   1180 C CA  . VAL A 1 219 ? 118.890 97.912  112.935 1.00 79.41  ? 219 VAL A CA  1 
ATOM   1181 C C   . VAL A 1 219 ? 117.920 98.468  113.979 1.00 79.41  ? 219 VAL A C   1 
ATOM   1182 O O   . VAL A 1 219 ? 116.768 98.031  114.045 1.00 79.41  ? 219 VAL A O   1 
ATOM   1183 C CB  . VAL A 1 219 ? 119.707 96.708  113.461 1.00 79.41  ? 219 VAL A CB  1 
ATOM   1184 C CG1 . VAL A 1 219 ? 120.530 97.054  114.686 1.00 79.41  ? 219 VAL A CG1 1 
ATOM   1185 C CG2 . VAL A 1 219 ? 118.806 95.509  113.737 1.00 79.41  ? 219 VAL A CG2 1 
ATOM   1186 N N   . GLY A 1 220 ? 118.310 99.497  114.731 1.00 75.62  ? 220 GLY A N   1 
ATOM   1187 C CA  . GLY A 1 220 ? 117.422 100.072 115.717 1.00 75.62  ? 220 GLY A CA  1 
ATOM   1188 C C   . GLY A 1 220 ? 116.355 100.944 115.102 1.00 75.62  ? 220 GLY A C   1 
ATOM   1189 O O   . GLY A 1 220 ? 115.206 100.906 115.543 1.00 75.62  ? 220 GLY A O   1 
ATOM   1190 N N   . GLN A 1 221 ? 116.723 101.724 114.079 1.00 73.66  ? 221 GLN A N   1 
ATOM   1191 C CA  . GLN A 1 221 ? 115.746 102.489 113.316 1.00 73.66  ? 221 GLN A CA  1 
ATOM   1192 C C   . GLN A 1 221 ? 114.741 101.578 112.628 1.00 73.66  ? 221 GLN A C   1 
ATOM   1193 O O   . GLN A 1 221 ? 113.534 101.844 112.661 1.00 73.66  ? 221 GLN A O   1 
ATOM   1194 C CB  . GLN A 1 221 ? 116.472 103.363 112.294 1.00 73.66  ? 221 GLN A CB  1 
ATOM   1195 C CG  . GLN A 1 221 ? 115.567 104.072 111.324 1.00 73.66  ? 221 GLN A CG  1 
ATOM   1196 C CD  . GLN A 1 221 ? 114.655 105.048 111.998 1.00 73.66  ? 221 GLN A CD  1 
ATOM   1197 O OE1 . GLN A 1 221 ? 115.070 105.810 112.868 1.00 73.66  ? 221 GLN A OE1 1 
ATOM   1198 N NE2 . GLN A 1 221 ? 113.390 105.017 111.619 1.00 73.66  ? 221 GLN A NE2 1 
ATOM   1199 N N   . THR A 1 222 ? 115.213 100.477 112.035 1.00 76.18  ? 222 THR A N   1 
ATOM   1200 C CA  . THR A 1 222 ? 114.297 99.581  111.338 1.00 76.18  ? 222 THR A CA  1 
ATOM   1201 C C   . THR A 1 222 ? 113.426 98.799  112.320 1.00 76.18  ? 222 THR A C   1 
ATOM   1202 O O   . THR A 1 222 ? 112.242 98.568  112.054 1.00 76.18  ? 222 THR A O   1 
ATOM   1203 C CB  . THR A 1 222 ? 115.090 98.644  110.426 1.00 76.18  ? 222 THR A CB  1 
ATOM   1204 O OG1 . THR A 1 222 ? 115.892 99.428  109.535 1.00 76.18  ? 222 THR A OG1 1 
ATOM   1205 C CG2 . THR A 1 222 ? 114.164 97.785  109.588 1.00 76.18  ? 222 THR A CG2 1 
ATOM   1206 N N   . ALA A 1 223 ? 113.971 98.431  113.484 1.00 72.16  ? 223 ALA A N   1 
ATOM   1207 C CA  . ALA A 1 223 ? 113.181 97.683  114.456 1.00 72.16  ? 223 ALA A CA  1 
ATOM   1208 C C   . ALA A 1 223 ? 112.177 98.578  115.170 1.00 72.16  ? 223 ALA A C   1 
ATOM   1209 O O   . ALA A 1 223 ? 111.057 98.147  115.461 1.00 72.16  ? 223 ALA A O   1 
ATOM   1210 C CB  . ALA A 1 223 ? 114.098 96.998  115.466 1.00 72.16  ? 223 ALA A CB  1 
ATOM   1211 N N   . GLY A 1 224 ? 112.552 99.823  115.464 1.00 70.54  ? 224 GLY A N   1 
ATOM   1212 C CA  . GLY A 1 224 ? 111.609 100.739 116.076 1.00 70.54  ? 224 GLY A CA  1 
ATOM   1213 C C   . GLY A 1 224 ? 110.551 101.218 115.110 1.00 70.54  ? 224 GLY A C   1 
ATOM   1214 O O   . GLY A 1 224 ? 109.413 101.475 115.510 1.00 70.54  ? 224 GLY A O   1 
ATOM   1215 N N   . TYR A 1 225 ? 110.908 101.357 113.832 1.00 69.93  ? 225 TYR A N   1 
ATOM   1216 C CA  . TYR A 1 225 ? 109.901 101.635 112.819 1.00 69.93  ? 225 TYR A CA  1 
ATOM   1217 C C   . TYR A 1 225 ? 108.990 100.436 112.622 1.00 69.93  ? 225 TYR A C   1 
ATOM   1218 O O   . TYR A 1 225 ? 107.823 100.599 112.258 1.00 69.93  ? 225 TYR A O   1 
ATOM   1219 C CB  . TYR A 1 225 ? 110.576 102.006 111.502 1.00 69.93  ? 225 TYR A CB  1 
ATOM   1220 C CG  . TYR A 1 225 ? 109.636 102.516 110.442 1.00 69.93  ? 225 TYR A CG  1 
ATOM   1221 C CD1 . TYR A 1 225 ? 109.219 103.836 110.445 1.00 69.93  ? 225 TYR A CD1 1 
ATOM   1222 C CD2 . TYR A 1 225 ? 109.161 101.679 109.442 1.00 69.93  ? 225 TYR A CD2 1 
ATOM   1223 C CE1 . TYR A 1 225 ? 108.366 104.315 109.479 1.00 69.93  ? 225 TYR A CE1 1 
ATOM   1224 C CE2 . TYR A 1 225 ? 108.300 102.149 108.474 1.00 69.93  ? 225 TYR A CE2 1 
ATOM   1225 C CZ  . TYR A 1 225 ? 107.906 103.470 108.500 1.00 69.93  ? 225 TYR A CZ  1 
ATOM   1226 O OH  . TYR A 1 225 ? 107.050 103.957 107.544 1.00 69.93  ? 225 TYR A OH  1 
ATOM   1227 N N   . PHE A 1 226 ? 109.509 99.229  112.853 1.00 69.76  ? 226 PHE A N   1 
ATOM   1228 C CA  . PHE A 1 226 ? 108.679 98.034  112.787 1.00 69.76  ? 226 PHE A CA  1 
ATOM   1229 C C   . PHE A 1 226 ? 107.688 97.981  113.939 1.00 69.76  ? 226 PHE A C   1 
ATOM   1230 O O   . PHE A 1 226 ? 106.551 97.535  113.761 1.00 69.76  ? 226 PHE A O   1 
ATOM   1231 C CB  . PHE A 1 226 ? 109.557 96.787  112.788 1.00 69.76  ? 226 PHE A CB  1 
ATOM   1232 C CG  . PHE A 1 226 ? 108.787 95.507  112.786 1.00 69.76  ? 226 PHE A CG  1 
ATOM   1233 C CD1 . PHE A 1 226 ? 108.164 95.068  111.636 1.00 69.76  ? 226 PHE A CD1 1 
ATOM   1234 C CD2 . PHE A 1 226 ? 108.694 94.737  113.934 1.00 69.76  ? 226 PHE A CD2 1 
ATOM   1235 C CE1 . PHE A 1 226 ? 107.459 93.889  111.630 1.00 69.76  ? 226 PHE A CE1 1 
ATOM   1236 C CE2 . PHE A 1 226 ? 107.986 93.557  113.934 1.00 69.76  ? 226 PHE A CE2 1 
ATOM   1237 C CZ  . PHE A 1 226 ? 107.367 93.132  112.780 1.00 69.76  ? 226 PHE A CZ  1 
ATOM   1238 N N   . LEU A 1 227 ? 108.097 98.424  115.128 1.00 67.48  ? 227 LEU A N   1 
ATOM   1239 C CA  . LEU A 1 227 ? 107.202 98.373  116.276 1.00 67.48  ? 227 LEU A CA  1 
ATOM   1240 C C   . LEU A 1 227 ? 106.159 99.478  116.261 1.00 67.48  ? 227 LEU A C   1 
ATOM   1241 O O   . LEU A 1 227 ? 105.217 99.420  117.054 1.00 67.48  ? 227 LEU A O   1 
ATOM   1242 C CB  . LEU A 1 227 ? 107.988 98.452  117.585 1.00 67.48  ? 227 LEU A CB  1 
ATOM   1243 C CG  . LEU A 1 227 ? 108.974 97.333  117.909 1.00 67.48  ? 227 LEU A CG  1 
ATOM   1244 C CD1 . LEU A 1 227 ? 109.671 97.619  119.224 1.00 67.48  ? 227 LEU A CD1 1 
ATOM   1245 C CD2 . LEU A 1 227 ? 108.301 95.981  117.939 1.00 67.48  ? 227 LEU A CD2 1 
ATOM   1246 N N   . GLY A 1 228 ? 106.294 100.467 115.386 1.00 64.70  ? 228 GLY A N   1 
ATOM   1247 C CA  . GLY A 1 228 ? 105.353 101.566 115.350 1.00 64.70  ? 228 GLY A CA  1 
ATOM   1248 C C   . GLY A 1 228 ? 104.479 101.590 114.116 1.00 64.70  ? 228 GLY A C   1 
ATOM   1249 O O   . GLY A 1 228 ? 103.358 102.100 114.160 1.00 64.70  ? 228 GLY A O   1 
ATOM   1250 N N   . ASN A 1 229 ? 104.981 101.072 112.999 1.00 66.54  ? 229 ASN A N   1 
ATOM   1251 C CA  . ASN A 1 229 ? 104.210 101.015 111.764 1.00 66.54  ? 229 ASN A CA  1 
ATOM   1252 C C   . ASN A 1 229 ? 103.517 99.676  111.573 1.00 66.54  ? 229 ASN A C   1 
ATOM   1253 O O   . ASN A 1 229 ? 102.362 99.639  111.147 1.00 66.54  ? 229 ASN A O   1 
ATOM   1254 C CB  . ASN A 1 229 ? 105.112 101.289 110.555 1.00 66.54  ? 229 ASN A CB  1 
ATOM   1255 C CG  . ASN A 1 229 ? 104.332 101.587 109.282 1.00 66.54  ? 229 ASN A CG  1 
ATOM   1256 O OD1 . ASN A 1 229 ? 103.107 101.683 109.287 1.00 66.54  ? 229 ASN A OD1 1 
ATOM   1257 N ND2 . ASN A 1 229 ? 105.050 101.723 108.176 1.00 66.54  ? 229 ASN A ND2 1 
ATOM   1258 N N   . VAL A 1 230 ? 104.184 98.573  111.882 1.00 67.09  ? 230 VAL A N   1 
ATOM   1259 C CA  . VAL A 1 230 ? 103.653 97.250  111.601 1.00 67.09  ? 230 VAL A CA  1 
ATOM   1260 C C   . VAL A 1 230 ? 103.013 96.631  112.833 1.00 67.09  ? 230 VAL A C   1 
ATOM   1261 O O   . VAL A 1 230 ? 101.911 96.090  112.757 1.00 67.09  ? 230 VAL A O   1 
ATOM   1262 C CB  . VAL A 1 230 ? 104.760 96.342  111.027 1.00 67.09  ? 230 VAL A CB  1 
ATOM   1263 C CG1 . VAL A 1 230 ? 104.191 94.984  110.674 1.00 67.09  ? 230 VAL A CG1 1 
ATOM   1264 C CG2 . VAL A 1 230 ? 105.403 96.997  109.822 1.00 67.09  ? 230 VAL A CG2 1 
ATOM   1265 N N   . LEU A 1 231 ? 103.691 96.705  113.983 1.00 66.77  ? 231 LEU A N   1 
ATOM   1266 C CA  . LEU A 1 231 ? 103.153 96.105  115.201 1.00 66.77  ? 231 LEU A CA  1 
ATOM   1267 C C   . LEU A 1 231 ? 101.930 96.861  115.695 1.00 66.77  ? 231 LEU A C   1 
ATOM   1268 O O   . LEU A 1 231 ? 100.954 96.248  116.142 1.00 66.77  ? 231 LEU A O   1 
ATOM   1269 C CB  . LEU A 1 231 ? 104.214 96.073  116.297 1.00 66.77  ? 231 LEU A CB  1 
ATOM   1270 C CG  . LEU A 1 231 ? 103.801 95.281  117.536 1.00 66.77  ? 231 LEU A CG  1 
ATOM   1271 C CD1 . LEU A 1 231 ? 103.770 93.799  117.205 1.00 66.77  ? 231 LEU A CD1 1 
ATOM   1272 C CD2 . LEU A 1 231 ? 104.694 95.564  118.724 1.00 66.77  ? 231 LEU A CD2 1 
ATOM   1273 N N   . PHE A 1 232 ? 101.954 98.191  115.593 1.00 67.03  ? 232 PHE A N   1 
ATOM   1274 C CA  . PHE A 1 232 ? 100.810 98.990  116.017 1.00 67.03  ? 232 PHE A CA  1 
ATOM   1275 C C   . PHE A 1 232 ? 99.589  98.757  115.137 1.00 67.03  ? 232 PHE A C   1 
ATOM   1276 O O   . PHE A 1 232 ? 98.471  98.639  115.650 1.00 67.03  ? 232 PHE A O   1 
ATOM   1277 C CB  . PHE A 1 232 ? 101.172 100.469 116.037 1.00 67.03  ? 232 PHE A CB  1 
ATOM   1278 C CG  . PHE A 1 232 ? 99.983  101.358 116.108 1.00 67.03  ? 232 PHE A CG  1 
ATOM   1279 C CD1 . PHE A 1 232 ? 99.203  101.405 117.243 1.00 67.03  ? 232 PHE A CD1 1 
ATOM   1280 C CD2 . PHE A 1 232 ? 99.637  102.141 115.028 1.00 67.03  ? 232 PHE A CD2 1 
ATOM   1281 C CE1 . PHE A 1 232 ? 98.097  102.215 117.292 1.00 67.03  ? 232 PHE A CE1 1 
ATOM   1282 C CE2 . PHE A 1 232 ? 98.541  102.949 115.080 1.00 67.03  ? 232 PHE A CE2 1 
ATOM   1283 C CZ  . PHE A 1 232 ? 97.765  102.983 116.208 1.00 67.03  ? 232 PHE A CZ  1 
ATOM   1284 N N   . LEU A 1 233 ? 99.770  98.703  113.816 1.00 65.30  ? 233 LEU A N   1 
ATOM   1285 C CA  . LEU A 1 233 ? 98.623  98.428  112.960 1.00 65.30  ? 233 LEU A CA  1 
ATOM   1286 C C   . LEU A 1 233 ? 98.159  96.986  113.092 1.00 65.30  ? 233 LEU A C   1 
ATOM   1287 O O   . LEU A 1 233 ? 96.954  96.731  113.079 1.00 65.30  ? 233 LEU A O   1 
ATOM   1288 C CB  . LEU A 1 233 ? 98.940  98.778  111.508 1.00 65.30  ? 233 LEU A CB  1 
ATOM   1289 C CG  . LEU A 1 233 ? 98.956  100.288 111.279 1.00 65.30  ? 233 LEU A CG  1 
ATOM   1290 C CD1 . LEU A 1 233 ? 99.423  100.664 109.896 1.00 65.30  ? 233 LEU A CD1 1 
ATOM   1291 C CD2 . LEU A 1 233 ? 97.568  100.835 111.518 1.00 65.30  ? 233 LEU A CD2 1 
ATOM   1292 N N   . ALA A 1 234 ? 99.082  96.044  113.284 1.00 72.31  ? 234 ALA A N   1 
ATOM   1293 C CA  . ALA A 1 234 ? 98.700  94.658  113.519 1.00 72.31  ? 234 ALA A CA  1 
ATOM   1294 C C   . ALA A 1 234 ? 97.987  94.467  114.848 1.00 72.31  ? 234 ALA A C   1 
ATOM   1295 O O   . ALA A 1 234 ? 97.223  93.510  114.995 1.00 72.31  ? 234 ALA A O   1 
ATOM   1296 C CB  . ALA A 1 234 ? 99.929  93.759  113.475 1.00 72.31  ? 234 ALA A CB  1 
ATOM   1297 N N   . LEU A 1 235 ? 98.220  95.346  115.819 1.00 74.75  ? 235 LEU A N   1 
ATOM   1298 C CA  . LEU A 1 235 ? 97.540  95.277  117.102 1.00 74.75  ? 235 LEU A CA  1 
ATOM   1299 C C   . LEU A 1 235 ? 96.502  96.381  117.268 1.00 74.75  ? 235 LEU A C   1 
ATOM   1300 O O   . LEU A 1 235 ? 96.043  96.628  118.385 1.00 74.75  ? 235 LEU A O   1 
ATOM   1301 C CB  . LEU A 1 235 ? 98.558  95.320  118.242 1.00 74.75  ? 235 LEU A CB  1 
ATOM   1302 C CG  . LEU A 1 235 ? 99.189  94.010  118.726 1.00 74.75  ? 235 LEU A CG  1 
ATOM   1303 C CD1 . LEU A 1 235 ? 100.109 93.374  117.706 1.00 74.75  ? 235 LEU A CD1 1 
ATOM   1304 C CD2 . LEU A 1 235 ? 99.956  94.264  120.012 1.00 74.75  ? 235 LEU A CD2 1 
ATOM   1305 N N   . GLU A 1 236 ? 96.115  97.044  116.178 1.00 78.13  ? 236 GLU A N   1 
ATOM   1306 C CA  . GLU A 1 236 ? 95.193  98.170  116.253 1.00 78.13  ? 236 GLU A CA  1 
ATOM   1307 C C   . GLU A 1 236 ? 93.754  97.804  115.924 1.00 78.13  ? 236 GLU A C   1 
ATOM   1308 O O   . GLU A 1 236 ? 92.835  98.392  116.502 1.00 78.13  ? 236 GLU A O   1 
ATOM   1309 C CB  . GLU A 1 236 ? 95.660  99.290  115.314 1.00 78.13  ? 236 GLU A CB  1 
ATOM   1310 C CG  . GLU A 1 236 ? 95.020  100.661 115.541 1.00 78.13  ? 236 GLU A CG  1 
ATOM   1311 C CD  . GLU A 1 236 ? 93.759  100.881 114.732 1.00 78.13  ? 236 GLU A CD  1 
ATOM   1312 O OE1 . GLU A 1 236 ? 93.641  100.287 113.642 1.00 78.13  ? 236 GLU A OE1 1 
ATOM   1313 O OE2 . GLU A 1 236 ? 92.887  101.651 115.185 1.00 78.13  ? 236 GLU A OE2 1 
ATOM   1314 N N   . SER A 1 237 ? 93.525  96.860  115.022 1.00 88.43  ? 237 SER A N   1 
ATOM   1315 C CA  . SER A 1 237 ? 92.177  96.573  114.560 1.00 88.43  ? 237 SER A CA  1 
ATOM   1316 C C   . SER A 1 237 ? 91.582  95.375  115.278 1.00 88.43  ? 237 SER A C   1 
ATOM   1317 O O   . SER A 1 237 ? 92.282  94.576  115.899 1.00 88.43  ? 237 SER A O   1 
ATOM   1318 C CB  . SER A 1 237 ? 92.157  96.297  113.064 1.00 88.43  ? 237 SER A CB  1 
ATOM   1319 O OG  . SER A 1 237 ? 92.830  95.087  112.771 1.00 88.43  ? 237 SER A OG  1 
ATOM   1320 N N   . ALA A 1 238 ? 90.263  95.250  115.155 1.00 95.75  ? 238 ALA A N   1 
ATOM   1321 C CA  . ALA A 1 238 ? 89.567  94.078  115.655 1.00 95.75  ? 238 ALA A CA  1 
ATOM   1322 C C   . ALA A 1 238 ? 89.616  92.915  114.679 1.00 95.75  ? 238 ALA A C   1 
ATOM   1323 O O   . ALA A 1 238 ? 89.528  91.764  115.113 1.00 95.75  ? 238 ALA A O   1 
ATOM   1324 C CB  . ALA A 1 238 ? 88.111  94.426  115.969 1.00 95.75  ? 238 ALA A CB  1 
ATOM   1325 N N   . ASP A 1 239 ? 89.782  93.187  113.382 1.00 101.02 ? 239 ASP A N   1 
ATOM   1326 C CA  . ASP A 1 239 ? 89.703  92.131  112.377 1.00 101.02 ? 239 ASP A CA  1 
ATOM   1327 C C   . ASP A 1 239 ? 90.909  91.201  112.459 1.00 101.02 ? 239 ASP A C   1 
ATOM   1328 O O   . ASP A 1 239 ? 90.755  89.979  112.588 1.00 101.02 ? 239 ASP A O   1 
ATOM   1329 C CB  . ASP A 1 239 ? 89.585  92.751  110.983 1.00 101.02 ? 239 ASP A CB  1 
ATOM   1330 C CG  . ASP A 1 239 ? 89.090  91.765  109.936 1.00 101.02 ? 239 ASP A CG  1 
ATOM   1331 O OD1 . ASP A 1 239 ? 88.802  90.601  110.285 1.00 101.02 ? 239 ASP A OD1 1 
ATOM   1332 O OD2 . ASP A 1 239 ? 88.987  92.158  108.754 1.00 101.02 ? 239 ASP A OD2 1 
ATOM   1333 N N   . PHE A 1 240 ? 92.121  91.763  112.409 1.00 93.80  ? 240 PHE A N   1 
ATOM   1334 C CA  . PHE A 1 240 ? 93.312  90.925  112.498 1.00 93.80  ? 240 PHE A CA  1 
ATOM   1335 C C   . PHE A 1 240 ? 93.490  90.363  113.902 1.00 93.80  ? 240 PHE A C   1 
ATOM   1336 O O   . PHE A 1 240 ? 93.945  89.226  114.065 1.00 93.80  ? 240 PHE A O   1 
ATOM   1337 C CB  . PHE A 1 240 ? 94.560  91.702  112.079 1.00 93.80  ? 240 PHE A CB  1 
ATOM   1338 C CG  . PHE A 1 240 ? 95.810  90.871  112.104 1.00 93.80  ? 240 PHE A CG  1 
ATOM   1339 C CD1 . PHE A 1 240 ? 96.048  89.939  111.111 1.00 93.80  ? 240 PHE A CD1 1 
ATOM   1340 C CD2 . PHE A 1 240 ? 96.728  90.999  113.131 1.00 93.80  ? 240 PHE A CD2 1 
ATOM   1341 C CE1 . PHE A 1 240 ? 97.183  89.163  111.132 1.00 93.80  ? 240 PHE A CE1 1 
ATOM   1342 C CE2 . PHE A 1 240 ? 97.864  90.223  113.161 1.00 93.80  ? 240 PHE A CE2 1 
ATOM   1343 C CZ  . PHE A 1 240 ? 98.086  89.294  112.165 1.00 93.80  ? 240 PHE A CZ  1 
ATOM   1344 N N   . CYS A 1 241 ? 93.126  91.130  114.926 1.00 97.07  ? 241 CYS A N   1 
ATOM   1345 C CA  . CYS A 1 241 ? 93.274  90.640  116.288 1.00 97.07  ? 241 CYS A CA  1 
ATOM   1346 C C   . CYS A 1 241 ? 92.172  89.680  116.702 1.00 97.07  ? 241 CYS A C   1 
ATOM   1347 O O   . CYS A 1 241 ? 92.251  89.120  117.796 1.00 97.07  ? 241 CYS A O   1 
ATOM   1348 C CB  . CYS A 1 241 ? 93.327  91.803  117.274 1.00 97.07  ? 241 CYS A CB  1 
ATOM   1349 S SG  . CYS A 1 241 ? 94.791  92.824  117.098 1.00 97.07  ? 241 CYS A SG  1 
ATOM   1350 N N   . ASN A 1 242 ? 91.143  89.482  115.880 1.00 99.40  ? 242 ASN A N   1 
ATOM   1351 C CA  . ASN A 1 242 ? 90.198  88.408  116.126 1.00 99.40  ? 242 ASN A CA  1 
ATOM   1352 C C   . ASN A 1 242 ? 90.358  87.241  115.170 1.00 99.40  ? 242 ASN A C   1 
ATOM   1353 O O   . ASN A 1 242 ? 89.840  86.157  115.455 1.00 99.40  ? 242 ASN A O   1 
ATOM   1354 C CB  . ASN A 1 242 ? 88.758  88.928  116.063 1.00 99.40  ? 242 ASN A CB  1 
ATOM   1355 C CG  . ASN A 1 242 ? 88.426  89.828  117.228 1.00 99.40  ? 242 ASN A CG  1 
ATOM   1356 O OD1 . ASN A 1 242 ? 88.871  89.591  118.348 1.00 99.40  ? 242 ASN A OD1 1 
ATOM   1357 N ND2 . ASN A 1 242 ? 87.648  90.871  116.972 1.00 99.40  ? 242 ASN A ND2 1 
ATOM   1358 N N   . LYS A 1 243 ? 91.055  87.430  114.049 1.00 99.73  ? 243 LYS A N   1 
ATOM   1359 C CA  . LYS A 1 243 ? 91.494  86.273  113.278 1.00 99.73  ? 243 LYS A CA  1 
ATOM   1360 C C   . LYS A 1 243 ? 92.672  85.583  113.957 1.00 99.73  ? 243 LYS A C   1 
ATOM   1361 O O   . LYS A 1 243 ? 92.652  84.366  114.166 1.00 99.73  ? 243 LYS A O   1 
ATOM   1362 C CB  . LYS A 1 243 ? 91.857  86.683  111.851 1.00 99.73  ? 243 LYS A CB  1 
ATOM   1363 C CG  . LYS A 1 243 ? 90.662  87.068  110.996 1.00 99.73  ? 243 LYS A CG  1 
ATOM   1364 C CD  . LYS A 1 243 ? 91.078  87.380  109.570 1.00 99.73  ? 243 LYS A CD  1 
ATOM   1365 C CE  . LYS A 1 243 ? 89.888  87.835  108.743 1.00 99.73  ? 243 LYS A CE  1 
ATOM   1366 N NZ  . LYS A 1 243 ? 88.893  86.744  108.557 1.00 99.73  ? 243 LYS A NZ  1 
ATOM   1367 N N   . TYR A 1 244 ? 93.701  86.346  114.317 1.00 100.10 ? 244 TYR A N   1 
ATOM   1368 C CA  . TYR A 1 244 ? 94.907  85.824  114.942 1.00 100.10 ? 244 TYR A CA  1 
ATOM   1369 C C   . TYR A 1 244 ? 95.088  86.442  116.324 1.00 100.10 ? 244 TYR A C   1 
ATOM   1370 O O   . TYR A 1 244 ? 94.318  87.306  116.751 1.00 100.10 ? 244 TYR A O   1 
ATOM   1371 C CB  . TYR A 1 244 ? 96.143  86.111  114.077 1.00 100.10 ? 244 TYR A CB  1 
ATOM   1372 C CG  . TYR A 1 244 ? 96.214  85.345  112.772 1.00 100.10 ? 244 TYR A CG  1 
ATOM   1373 C CD1 . TYR A 1 244 ? 95.447  84.205  112.560 1.00 100.10 ? 244 TYR A CD1 1 
ATOM   1374 C CD2 . TYR A 1 244 ? 97.055  85.765  111.750 1.00 100.10 ? 244 TYR A CD2 1 
ATOM   1375 C CE1 . TYR A 1 244 ? 95.515  83.507  111.365 1.00 100.10 ? 244 TYR A CE1 1 
ATOM   1376 C CE2 . TYR A 1 244 ? 97.129  85.078  110.552 1.00 100.10 ? 244 TYR A CE2 1 
ATOM   1377 C CZ  . TYR A 1 244 ? 96.358  83.950  110.366 1.00 100.10 ? 244 TYR A CZ  1 
ATOM   1378 O OH  . TYR A 1 244 ? 96.430  83.261  109.178 1.00 100.10 ? 244 TYR A OH  1 
ATOM   1379 N N   . LEU A 1 245 ? 96.111  85.949  117.030 1.00 99.64  ? 245 LEU A N   1 
ATOM   1380 C CA  . LEU A 1 245 ? 96.663  86.520  118.265 1.00 99.64  ? 245 LEU A CA  1 
ATOM   1381 C C   . LEU A 1 245 ? 95.684  86.538  119.439 1.00 99.64  ? 245 LEU A C   1 
ATOM   1382 O O   . LEU A 1 245 ? 95.946  87.214  120.439 1.00 99.64  ? 245 LEU A O   1 
ATOM   1383 C CB  . LEU A 1 245 ? 97.206  87.938  118.039 1.00 99.64  ? 245 LEU A CB  1 
ATOM   1384 C CG  . LEU A 1 245 ? 98.455  88.111  117.179 1.00 99.64  ? 245 LEU A CG  1 
ATOM   1385 C CD1 . LEU A 1 245 ? 98.742  89.585  116.970 1.00 99.64  ? 245 LEU A CD1 1 
ATOM   1386 C CD2 . LEU A 1 245 ? 99.643  87.426  117.828 1.00 99.64  ? 245 LEU A CD2 1 
ATOM   1387 N N   . ARG A 1 246 ? 94.578  85.797  119.375 1.00 104.36 ? 246 ARG A N   1 
ATOM   1388 C CA  . ARG A 1 246 ? 93.578  85.870  120.434 1.00 104.36 ? 246 ARG A CA  1 
ATOM   1389 C C   . ARG A 1 246 ? 92.679  84.644  120.402 1.00 104.36 ? 246 ARG A C   1 
ATOM   1390 O O   . ARG A 1 246 ? 92.216  84.236  119.334 1.00 104.36 ? 246 ARG A O   1 
ATOM   1391 C CB  . ARG A 1 246 ? 92.729  87.137  120.291 1.00 104.36 ? 246 ARG A CB  1 
ATOM   1392 C CG  . ARG A 1 246 ? 91.660  87.315  121.342 1.00 104.36 ? 246 ARG A CG  1 
ATOM   1393 C CD  . ARG A 1 246 ? 90.873  88.583  121.088 1.00 104.36 ? 246 ARG A CD  1 
ATOM   1394 N NE  . ARG A 1 246 ? 91.618  89.794  121.407 1.00 104.36 ? 246 ARG A NE  1 
ATOM   1395 C CZ  . ARG A 1 246 ? 91.234  91.011  121.042 1.00 104.36 ? 246 ARG A CZ  1 
ATOM   1396 N NH1 . ARG A 1 246 ? 90.136  91.170  120.322 1.00 104.36 ? 246 ARG A NH1 1 
ATOM   1397 N NH2 . ARG A 1 246 ? 91.953  92.066  121.379 1.00 104.36 ? 246 ARG A NH2 1 
ATOM   1398 N N   . PHE A 1 247 ? 92.439  84.068  121.575 1.00 112.79 ? 247 PHE A N   1 
ATOM   1399 C CA  . PHE A 1 247 ? 91.353  83.129  121.803 1.00 112.79 ? 247 PHE A CA  1 
ATOM   1400 C C   . PHE A 1 247 ? 90.231  83.868  122.526 1.00 112.79 ? 247 PHE A C   1 
ATOM   1401 O O   . PHE A 1 247 ? 90.488  84.821  123.269 1.00 112.79 ? 247 PHE A O   1 
ATOM   1402 C CB  . PHE A 1 247 ? 91.843  81.932  122.623 1.00 112.79 ? 247 PHE A CB  1 
ATOM   1403 C CG  . PHE A 1 247 ? 90.815  80.856  122.815 1.00 112.79 ? 247 PHE A CG  1 
ATOM   1404 C CD1 . PHE A 1 247 ? 90.473  80.012  121.771 1.00 112.79 ? 247 PHE A CD1 1 
ATOM   1405 C CD2 . PHE A 1 247 ? 90.206  80.675  124.048 1.00 112.79 ? 247 PHE A CD2 1 
ATOM   1406 C CE1 . PHE A 1 247 ? 89.530  79.016  121.947 1.00 112.79 ? 247 PHE A CE1 1 
ATOM   1407 C CE2 . PHE A 1 247 ? 89.263  79.680  124.232 1.00 112.79 ? 247 PHE A CE2 1 
ATOM   1408 C CZ  . PHE A 1 247 ? 88.924  78.850  123.180 1.00 112.79 ? 247 PHE A CZ  1 
ATOM   1409 N N   . GLN A 1 248 ? 88.978  83.412  122.305 1.00 115.39 ? 248 GLN A N   1 
ATOM   1410 C CA  . GLN A 1 248 ? 87.740  84.080  122.722 1.00 115.39 ? 248 GLN A CA  1 
ATOM   1411 C C   . GLN A 1 248 ? 87.707  85.519  122.214 1.00 115.39 ? 248 GLN A C   1 
ATOM   1412 O O   . GLN A 1 248 ? 87.996  86.449  122.977 1.00 115.39 ? 248 GLN A O   1 
ATOM   1413 C CB  . GLN A 1 248 ? 87.551  84.044  124.243 1.00 115.39 ? 248 GLN A CB  1 
ATOM   1414 C CG  . GLN A 1 248 ? 87.250  82.667  124.805 1.00 115.39 ? 248 GLN A CG  1 
ATOM   1415 C CD  . GLN A 1 248 ? 87.085  82.678  126.310 1.00 115.39 ? 248 GLN A CD  1 
ATOM   1416 O OE1 . GLN A 1 248 ? 87.265  83.709  126.958 1.00 115.39 ? 248 GLN A OE1 1 
ATOM   1417 N NE2 . GLN A 1 248 ? 86.738  81.529  126.876 1.00 115.39 ? 248 GLN A NE2 1 
ATOM   1418 N N   . PRO A 1 249 ? 87.404  85.724  120.928 1.00 113.62 ? 249 PRO A N   1 
ATOM   1419 C CA  . PRO A 1 249 ? 87.579  87.048  120.311 1.00 113.62 ? 249 PRO A CA  1 
ATOM   1420 C C   . PRO A 1 249 ? 86.641  88.112  120.866 1.00 113.62 ? 249 PRO A C   1 
ATOM   1421 O O   . PRO A 1 249 ? 85.487  87.842  121.202 1.00 113.62 ? 249 PRO A O   1 
ATOM   1422 C CB  . PRO A 1 249 ? 87.288  86.780  118.830 1.00 113.62 ? 249 PRO A CB  1 
ATOM   1423 C CG  . PRO A 1 249 ? 86.387  85.604  118.833 1.00 113.62 ? 249 PRO A CG  1 
ATOM   1424 C CD  . PRO A 1 249 ? 86.832  84.748  119.985 1.00 113.62 ? 249 PRO A CD  1 
ATOM   1425 N N   . GLN A 1 250 ? 87.163  89.333  120.955 1.00 108.60 ? 250 GLN A N   1 
ATOM   1426 C CA  . GLN A 1 250 ? 86.475  90.497  121.492 1.00 108.60 ? 250 GLN A CA  1 
ATOM   1427 C C   . GLN A 1 250 ? 86.810  91.699  120.618 1.00 108.60 ? 250 GLN A C   1 
ATOM   1428 O O   . GLN A 1 250 ? 87.857  91.708  119.961 1.00 108.60 ? 250 GLN A O   1 
ATOM   1429 C CB  . GLN A 1 250 ? 86.884  90.751  122.958 1.00 108.60 ? 250 GLN A CB  1 
ATOM   1430 C CG  . GLN A 1 250 ? 88.339  91.126  123.168 1.00 108.60 ? 250 GLN A CG  1 
ATOM   1431 C CD  . GLN A 1 250 ? 88.682  91.333  124.629 1.00 108.60 ? 250 GLN A CD  1 
ATOM   1432 O OE1 . GLN A 1 250 ? 87.818  91.245  125.501 1.00 108.60 ? 250 GLN A OE1 1 
ATOM   1433 N NE2 . GLN A 1 250 ? 89.950  91.614  124.903 1.00 108.60 ? 250 GLN A NE2 1 
ATOM   1434 N N   . PRO A 1 251 ? 85.937  92.731  120.573 1.00 106.64 ? 251 PRO A N   1 
ATOM   1435 C CA  . PRO A 1 251 ? 86.203  93.867  119.673 1.00 106.64 ? 251 PRO A CA  1 
ATOM   1436 C C   . PRO A 1 251 ? 87.324  94.796  120.122 1.00 106.64 ? 251 PRO A C   1 
ATOM   1437 O O   . PRO A 1 251 ? 88.104  94.465  121.018 1.00 106.64 ? 251 PRO A O   1 
ATOM   1438 C CB  . PRO A 1 251 ? 84.860  94.605  119.634 1.00 106.64 ? 251 PRO A CB  1 
ATOM   1439 C CG  . PRO A 1 251 ? 84.190  94.240  120.897 1.00 106.64 ? 251 PRO A CG  1 
ATOM   1440 C CD  . PRO A 1 251 ? 84.589  92.824  121.167 1.00 106.64 ? 251 PRO A CD  1 
ATOM   1441 N N   . ARG A 1 252 ? 87.442  95.927  119.410 1.00 103.45 ? 252 ARG A N   1 
ATOM   1442 C CA  . ARG A 1 252 ? 88.335  97.079  119.637 1.00 103.45 ? 252 ARG A CA  1 
ATOM   1443 C C   . ARG A 1 252 ? 89.825  96.720  119.721 1.00 103.45 ? 252 ARG A C   1 
ATOM   1444 O O   . ARG A 1 252 ? 90.631  97.544  120.166 1.00 103.45 ? 252 ARG A O   1 
ATOM   1445 C CB  . ARG A 1 252 ? 87.917  97.927  120.862 1.00 103.45 ? 252 ARG A CB  1 
ATOM   1446 C CG  . ARG A 1 252 ? 88.147  97.368  122.272 1.00 103.45 ? 252 ARG A CG  1 
ATOM   1447 C CD  . ARG A 1 252 ? 87.721  98.340  123.358 1.00 103.45 ? 252 ARG A CD  1 
ATOM   1448 N NE  . ARG A 1 252 ? 87.790  97.731  124.685 1.00 103.45 ? 252 ARG A NE  1 
ATOM   1449 C CZ  . ARG A 1 252 ? 88.882  97.695  125.442 1.00 103.45 ? 252 ARG A CZ  1 
ATOM   1450 N NH1 . ARG A 1 252 ? 90.014  98.233  125.009 1.00 103.45 ? 252 ARG A NH1 1 
ATOM   1451 N NH2 . ARG A 1 252 ? 88.842  97.118  126.635 1.00 103.45 ? 252 ARG A NH2 1 
ATOM   1452 N N   . GLY A 1 253 ? 90.226  95.533  119.267 1.00 93.22  ? 253 GLY A N   1 
ATOM   1453 C CA  . GLY A 1 253 ? 91.634  95.212  119.087 1.00 93.22  ? 253 GLY A CA  1 
ATOM   1454 C C   . GLY A 1 253 ? 92.409  95.049  120.386 1.00 93.22  ? 253 GLY A C   1 
ATOM   1455 O O   . GLY A 1 253 ? 91.873  95.119  121.489 1.00 93.22  ? 253 GLY A O   1 
ATOM   1456 N N   . ILE A 1 254 ? 93.715  94.814  120.230 1.00 83.81  ? 254 ILE A N   1 
ATOM   1457 C CA  . ILE A 1 254 ? 94.601  94.725  121.390 1.00 83.81  ? 254 ILE A CA  1 
ATOM   1458 C C   . ILE A 1 254 ? 94.836  96.107  121.984 1.00 83.81  ? 254 ILE A C   1 
ATOM   1459 O O   . ILE A 1 254 ? 94.517  96.363  123.150 1.00 83.81  ? 254 ILE A O   1 
ATOM   1460 C CB  . ILE A 1 254 ? 95.932  94.052  121.014 1.00 83.81  ? 254 ILE A CB  1 
ATOM   1461 C CG1 . ILE A 1 254 ? 95.715  92.592  120.621 1.00 83.81  ? 254 ILE A CG1 1 
ATOM   1462 C CG2 . ILE A 1 254 ? 96.905  94.133  122.178 1.00 83.81  ? 254 ILE A CG2 1 
ATOM   1463 C CD1 . ILE A 1 254 ? 95.261  91.714  121.764 1.00 83.81  ? 254 ILE A CD1 1 
ATOM   1464 N N   . VAL A 1 255 ? 95.411  97.013  121.198 1.00 80.11  ? 255 VAL A N   1 
ATOM   1465 C CA  . VAL A 1 255 ? 95.724  98.358  121.657 1.00 80.11  ? 255 VAL A CA  1 
ATOM   1466 C C   . VAL A 1 255 ? 95.157  99.373  120.677 1.00 80.11  ? 255 VAL A C   1 
ATOM   1467 O O   . VAL A 1 255 ? 95.209  99.182  119.458 1.00 80.11  ? 255 VAL A O   1 
ATOM   1468 C CB  . VAL A 1 255 ? 97.244  98.568  121.853 1.00 80.11  ? 255 VAL A CB  1 
ATOM   1469 C CG1 . VAL A 1 255 ? 97.737  97.788  123.061 1.00 80.11  ? 255 VAL A CG1 1 
ATOM   1470 C CG2 . VAL A 1 255 ? 98.027  98.142  120.621 1.00 80.11  ? 255 VAL A CG2 1 
ATOM   1471 N N   . THR A 1 256 ? 94.588  100.443 121.215 1.00 77.20  ? 256 THR A N   1 
ATOM   1472 C CA  . THR A 1 256 ? 94.205  101.583 120.405 1.00 77.20  ? 256 THR A CA  1 
ATOM   1473 C C   . THR A 1 256 ? 95.418  102.491 120.240 1.00 77.20  ? 256 THR A C   1 
ATOM   1474 O O   . THR A 1 256 ? 96.501  102.213 120.756 1.00 77.20  ? 256 THR A O   1 
ATOM   1475 C CB  . THR A 1 256 ? 93.033  102.326 121.041 1.00 77.20  ? 256 THR A CB  1 
ATOM   1476 O OG1 . THR A 1 256 ? 93.426  102.830 122.323 1.00 77.20  ? 256 THR A OG1 1 
ATOM   1477 C CG2 . THR A 1 256 ? 91.850  101.393 121.216 1.00 77.20  ? 256 THR A CG2 1 
ATOM   1478 N N   . LEU A 1 257 ? 95.246  103.593 119.509 1.00 70.23  ? 257 LEU A N   1 
ATOM   1479 C CA  . LEU A 1 257 ? 96.342  104.547 119.394 1.00 70.23  ? 257 LEU A CA  1 
ATOM   1480 C C   . LEU A 1 257 ? 96.554  105.305 120.696 1.00 70.23  ? 257 LEU A C   1 
ATOM   1481 O O   . LEU A 1 257 ? 97.689  105.680 121.009 1.00 70.23  ? 257 LEU A O   1 
ATOM   1482 C CB  . LEU A 1 257 ? 96.095  105.499 118.223 1.00 70.23  ? 257 LEU A CB  1 
ATOM   1483 C CG  . LEU A 1 257 ? 97.107  106.615 117.942 1.00 70.23  ? 257 LEU A CG  1 
ATOM   1484 C CD1 . LEU A 1 257 ? 98.507  106.089 117.773 1.00 70.23  ? 257 LEU A CD1 1 
ATOM   1485 C CD2 . LEU A 1 257 ? 96.714  107.332 116.693 1.00 70.23  ? 257 LEU A CD2 1 
ATOM   1486 N N   . SER A 1 258 ? 95.495  105.490 121.486 1.00 73.42  ? 258 SER A N   1 
ATOM   1487 C CA  . SER A 1 258 ? 95.640  106.146 122.782 1.00 73.42  ? 258 SER A CA  1 
ATOM   1488 C C   . SER A 1 258 ? 96.466  105.296 123.742 1.00 73.42  ? 258 SER A C   1 
ATOM   1489 O O   . SER A 1 258 ? 97.390  105.800 124.393 1.00 73.42  ? 258 SER A O   1 
ATOM   1490 C CB  . SER A 1 258 ? 94.265  106.447 123.375 1.00 73.42  ? 258 SER A CB  1 
ATOM   1491 O OG  . SER A 1 258 ? 94.387  107.051 124.650 1.00 73.42  ? 258 SER A OG  1 
ATOM   1492 N N   . ASP A 1 259 ? 96.183  103.992 123.803 1.00 73.34  ? 259 ASP A N   1 
ATOM   1493 C CA  . ASP A 1 259 ? 96.914  103.110 124.708 1.00 73.34  ? 259 ASP A CA  1 
ATOM   1494 C C   . ASP A 1 259 ? 98.351  102.905 124.235 1.00 73.34  ? 259 ASP A C   1 
ATOM   1495 O O   . ASP A 1 259 ? 99.275  102.846 125.054 1.00 73.34  ? 259 ASP A O   1 
ATOM   1496 C CB  . ASP A 1 259 ? 96.184  101.772 124.822 1.00 73.34  ? 259 ASP A CB  1 
ATOM   1497 C CG  . ASP A 1 259 ? 96.614  100.962 126.034 1.00 73.34  ? 259 ASP A CG  1 
ATOM   1498 O OD1 . ASP A 1 259 ? 97.467  101.431 126.813 1.00 73.34  ? 259 ASP A OD1 1 
ATOM   1499 O OD2 . ASP A 1 259 ? 96.089  99.844  126.211 1.00 73.34  ? 259 ASP A OD2 1 
ATOM   1500 N N   . PHE A 1 260 ? 98.557  102.836 122.917 1.00 65.76  ? 260 PHE A N   1 
ATOM   1501 C CA  . PHE A 1 260 ? 99.897  102.656 122.364 1.00 65.76  ? 260 PHE A CA  1 
ATOM   1502 C C   . PHE A 1 260 ? 100.763 103.886 122.609 1.00 65.76  ? 260 PHE A C   1 
ATOM   1503 O O   . PHE A 1 260 ? 101.925 103.767 123.024 1.00 65.76  ? 260 PHE A O   1 
ATOM   1504 C CB  . PHE A 1 260 ? 99.791  102.367 120.870 1.00 65.76  ? 260 PHE A CB  1 
ATOM   1505 C CG  . PHE A 1 260 ? 101.077 101.959 120.229 1.00 65.76  ? 260 PHE A CG  1 
ATOM   1506 C CD1 . PHE A 1 260 ? 101.529 100.658 120.334 1.00 65.76  ? 260 PHE A CD1 1 
ATOM   1507 C CD2 . PHE A 1 260 ? 101.827 102.869 119.507 1.00 65.76  ? 260 PHE A CD2 1 
ATOM   1508 C CE1 . PHE A 1 260 ? 102.704 100.272 119.734 1.00 65.76  ? 260 PHE A CE1 1 
ATOM   1509 C CE2 . PHE A 1 260 ? 103.004 102.488 118.907 1.00 65.76  ? 260 PHE A CE2 1 
ATOM   1510 C CZ  . PHE A 1 260 ? 103.439 101.192 119.018 1.00 65.76  ? 260 PHE A CZ  1 
ATOM   1511 N N   . LEU A 1 261 ? 100.207 105.077 122.360 1.00 69.43  ? 261 LEU A N   1 
ATOM   1512 C CA  . LEU A 1 261 ? 100.926 106.317 122.637 1.00 69.43  ? 261 LEU A CA  1 
ATOM   1513 C C   . LEU A 1 261 ? 101.200 106.488 124.123 1.00 69.43  ? 261 LEU A C   1 
ATOM   1514 O O   . LEU A 1 261 ? 102.284 106.938 124.501 1.00 69.43  ? 261 LEU A O   1 
ATOM   1515 C CB  . LEU A 1 261 ? 100.145 107.519 122.111 1.00 69.43  ? 261 LEU A CB  1 
ATOM   1516 C CG  . LEU A 1 261 ? 100.138 107.859 120.625 1.00 69.43  ? 261 LEU A CG  1 
ATOM   1517 C CD1 . LEU A 1 261 ? 99.059  108.874 120.356 1.00 69.43  ? 261 LEU A CD1 1 
ATOM   1518 C CD2 . LEU A 1 261 ? 101.456 108.443 120.233 1.00 69.43  ? 261 LEU A CD2 1 
ATOM   1519 N N   . PHE A 1 262 ? 100.246 106.112 124.982 1.00 69.03  ? 262 PHE A N   1 
ATOM   1520 C CA  . PHE A 1 262 ? 100.456 106.260 126.419 1.00 69.03  ? 262 PHE A CA  1 
ATOM   1521 C C   . PHE A 1 262 ? 101.526 105.303 126.927 1.00 69.03  ? 262 PHE A C   1 
ATOM   1522 O O   . PHE A 1 262 ? 102.367 105.687 127.751 1.00 69.03  ? 262 PHE A O   1 
ATOM   1523 C CB  . PHE A 1 262 ? 99.142  106.041 127.164 1.00 69.03  ? 262 PHE A CB  1 
ATOM   1524 C CG  . PHE A 1 262 ? 99.246  106.238 128.643 1.00 69.03  ? 262 PHE A CG  1 
ATOM   1525 C CD1 . PHE A 1 262 ? 99.332  107.511 129.176 1.00 69.03  ? 262 PHE A CD1 1 
ATOM   1526 C CD2 . PHE A 1 262 ? 99.245  105.153 129.502 1.00 69.03  ? 262 PHE A CD2 1 
ATOM   1527 C CE1 . PHE A 1 262 ? 99.428  107.703 130.539 1.00 69.03  ? 262 PHE A CE1 1 
ATOM   1528 C CE2 . PHE A 1 262 ? 99.337  105.336 130.867 1.00 69.03  ? 262 PHE A CE2 1 
ATOM   1529 C CZ  . PHE A 1 262 ? 99.429  106.615 131.386 1.00 69.03  ? 262 PHE A CZ  1 
ATOM   1530 N N   . PHE A 1 263 ? 101.541 104.069 126.412 1.00 67.71  ? 263 PHE A N   1 
ATOM   1531 C CA  . PHE A 1 263 ? 102.551 103.110 126.842 1.00 67.71  ? 263 PHE A CA  1 
ATOM   1532 C C   . PHE A 1 263 ? 103.937 103.496 126.355 1.00 67.71  ? 263 PHE A C   1 
ATOM   1533 O O   . PHE A 1 263 ? 104.900 103.438 127.128 1.00 67.71  ? 263 PHE A O   1 
ATOM   1534 C CB  . PHE A 1 263 ? 102.209 101.703 126.367 1.00 67.71  ? 263 PHE A CB  1 
ATOM   1535 C CG  . PHE A 1 263 ? 103.260 100.695 126.710 1.00 67.71  ? 263 PHE A CG  1 
ATOM   1536 C CD1 . PHE A 1 263 ? 103.451 100.299 128.022 1.00 67.71  ? 263 PHE A CD1 1 
ATOM   1537 C CD2 . PHE A 1 263 ? 104.058 100.144 125.724 1.00 67.71  ? 263 PHE A CD2 1 
ATOM   1538 C CE1 . PHE A 1 263 ? 104.423 99.375  128.344 1.00 67.71  ? 263 PHE A CE1 1 
ATOM   1539 C CE2 . PHE A 1 263 ? 105.029 99.220  126.038 1.00 67.71  ? 263 PHE A CE2 1 
ATOM   1540 C CZ  . PHE A 1 263 ? 105.212 98.833  127.350 1.00 67.71  ? 263 PHE A CZ  1 
ATOM   1541 N N   . TRP A 1 264 ? 104.073 103.896 125.089 1.00 66.27  ? 264 TRP A N   1 
ATOM   1542 C CA  . TRP A 1 264 ? 105.403 104.306 124.657 1.00 66.27  ? 264 TRP A CA  1 
ATOM   1543 C C   . TRP A 1 264 ? 105.811 105.654 125.227 1.00 66.27  ? 264 TRP A C   1 
ATOM   1544 O O   . TRP A 1 264 ? 107.007 105.896 125.373 1.00 66.27  ? 264 TRP A O   1 
ATOM   1545 C CB  . TRP A 1 264 ? 105.524 104.299 123.138 1.00 66.27  ? 264 TRP A CB  1 
ATOM   1546 C CG  . TRP A 1 264 ? 105.701 102.926 122.605 1.00 66.27  ? 264 TRP A CG  1 
ATOM   1547 C CD1 . TRP A 1 264 ? 104.756 102.147 122.027 1.00 66.27  ? 264 TRP A CD1 1 
ATOM   1548 C CD2 . TRP A 1 264 ? 106.900 102.144 122.638 1.00 66.27  ? 264 TRP A CD2 1 
ATOM   1549 N NE1 . TRP A 1 264 ? 105.290 100.932 121.679 1.00 66.27  ? 264 TRP A NE1 1 
ATOM   1550 C CE2 . TRP A 1 264 ? 106.607 100.907 122.043 1.00 66.27  ? 264 TRP A CE2 1 
ATOM   1551 C CE3 . TRP A 1 264 ? 108.192 102.374 123.107 1.00 66.27  ? 264 TRP A CE3 1 
ATOM   1552 C CZ2 . TRP A 1 264 ? 107.557 99.904  121.903 1.00 66.27  ? 264 TRP A CZ2 1 
ATOM   1553 C CZ3 . TRP A 1 264 ? 109.135 101.377 122.965 1.00 66.27  ? 264 TRP A CZ3 1 
ATOM   1554 C CH2 . TRP A 1 264 ? 108.813 100.159 122.369 1.00 66.27  ? 264 TRP A CH2 1 
ATOM   1555 N N   . GLY A 1 265 ? 104.865 106.500 125.633 1.00 65.61  ? 265 GLY A N   1 
ATOM   1556 C CA  . GLY A 1 265 ? 105.238 107.695 126.369 1.00 65.61  ? 265 GLY A CA  1 
ATOM   1557 C C   . GLY A 1 265 ? 105.766 107.376 127.753 1.00 65.61  ? 265 GLY A C   1 
ATOM   1558 O O   . GLY A 1 265 ? 106.729 107.995 128.216 1.00 65.61  ? 265 GLY A O   1 
ATOM   1559 N N   . THR A 1 266 ? 105.156 106.396 128.425 1.00 66.74  ? 266 THR A N   1 
ATOM   1560 C CA  . THR A 1 266 ? 105.678 105.944 129.711 1.00 66.74  ? 266 THR A CA  1 
ATOM   1561 C C   . THR A 1 266 ? 107.056 105.306 129.549 1.00 66.74  ? 266 THR A C   1 
ATOM   1562 O O   . THR A 1 266 ? 107.945 105.522 130.385 1.00 66.74  ? 266 THR A O   1 
ATOM   1563 C CB  . THR A 1 266 ? 104.691 104.971 130.354 1.00 66.74  ? 266 THR A CB  1 
ATOM   1564 O OG1 . THR A 1 266 ? 103.421 105.615 130.489 1.00 66.74  ? 266 THR A OG1 1 
ATOM   1565 C CG2 . THR A 1 266 ? 105.160 104.541 131.734 1.00 66.74  ? 266 THR A CG2 1 
ATOM   1566 N N   . VAL A 1 267 ? 107.262 104.562 128.456 1.00 67.61  ? 267 VAL A N   1 
ATOM   1567 C CA  . VAL A 1 267 ? 108.573 103.979 128.164 1.00 67.61  ? 267 VAL A CA  1 
ATOM   1568 C C   . VAL A 1 267 ? 109.607 105.072 127.906 1.00 67.61  ? 267 VAL A C   1 
ATOM   1569 O O   . VAL A 1 267 ? 110.742 104.984 128.392 1.00 67.61  ? 267 VAL A O   1 
ATOM   1570 C CB  . VAL A 1 267 ? 108.468 102.983 126.991 1.00 67.61  ? 267 VAL A CB  1 
ATOM   1571 C CG1 . VAL A 1 267 ? 109.834 102.562 126.495 1.00 67.61  ? 267 VAL A CG1 1 
ATOM   1572 C CG2 . VAL A 1 267 ? 107.713 101.745 127.431 1.00 67.61  ? 267 VAL A CG2 1 
ATOM   1573 N N   . PHE A 1 268 ? 109.218 106.136 127.187 1.00 67.64  ? 268 PHE A N   1 
ATOM   1574 C CA  . PHE A 1 268 ? 110.089 107.298 126.997 1.00 67.64  ? 268 PHE A CA  1 
ATOM   1575 C C   . PHE A 1 268 ? 110.481 107.950 128.315 1.00 67.64  ? 268 PHE A C   1 
ATOM   1576 O O   . PHE A 1 268 ? 111.661 108.236 128.537 1.00 67.64  ? 268 PHE A O   1 
ATOM   1577 C CB  . PHE A 1 268 ? 109.432 108.344 126.097 1.00 67.64  ? 268 PHE A CB  1 
ATOM   1578 C CG  . PHE A 1 268 ? 109.757 108.197 124.646 1.00 67.64  ? 268 PHE A CG  1 
ATOM   1579 C CD1 . PHE A 1 268 ? 111.017 108.523 124.191 1.00 67.64  ? 268 PHE A CD1 1 
ATOM   1580 C CD2 . PHE A 1 268 ? 108.801 107.825 123.729 1.00 67.64  ? 268 PHE A CD2 1 
ATOM   1581 C CE1 . PHE A 1 268 ? 111.327 108.414 122.862 1.00 67.64  ? 268 PHE A CE1 1 
ATOM   1582 C CE2 . PHE A 1 268 ? 109.110 107.724 122.396 1.00 67.64  ? 268 PHE A CE2 1 
ATOM   1583 C CZ  . PHE A 1 268 ? 110.371 108.026 121.967 1.00 67.64  ? 268 PHE A CZ  1 
ATOM   1584 N N   . LEU A 1 269 ? 109.505 108.197 129.196 1.00 69.10  ? 269 LEU A N   1 
ATOM   1585 C CA  . LEU A 1 269 ? 109.809 108.836 130.477 1.00 69.10  ? 269 LEU A CA  1 
ATOM   1586 C C   . LEU A 1 269 ? 110.716 107.973 131.351 1.00 69.10  ? 269 LEU A C   1 
ATOM   1587 O O   . LEU A 1 269 ? 111.668 108.487 131.956 1.00 69.10  ? 269 LEU A O   1 
ATOM   1588 C CB  . LEU A 1 269 ? 108.524 109.189 131.228 1.00 69.10  ? 269 LEU A CB  1 
ATOM   1589 C CG  . LEU A 1 269 ? 107.943 110.597 131.058 1.00 69.10  ? 269 LEU A CG  1 
ATOM   1590 C CD1 . LEU A 1 269 ? 107.360 110.840 129.696 1.00 69.10  ? 269 LEU A CD1 1 
ATOM   1591 C CD2 . LEU A 1 269 ? 106.894 110.861 132.127 1.00 69.10  ? 269 LEU A CD2 1 
ATOM   1592 N N   . ILE A 1 270 ? 110.482 106.657 131.392 1.00 68.69  ? 270 ILE A N   1 
ATOM   1593 C CA  . ILE A 1 270 ? 111.301 105.832 132.278 1.00 68.69  ? 270 ILE A CA  1 
ATOM   1594 C C   . ILE A 1 270 ? 112.702 105.628 131.700 1.00 68.69  ? 270 ILE A C   1 
ATOM   1595 O O   . ILE A 1 270 ? 113.693 105.679 132.441 1.00 68.69  ? 270 ILE A O   1 
ATOM   1596 C CB  . ILE A 1 270 ? 110.603 104.500 132.631 1.00 68.69  ? 270 ILE A CB  1 
ATOM   1597 C CG1 . ILE A 1 270 ? 110.360 103.608 131.414 1.00 68.69  ? 270 ILE A CG1 1 
ATOM   1598 C CG2 . ILE A 1 270 ? 109.297 104.765 133.360 1.00 68.69  ? 270 ILE A CG2 1 
ATOM   1599 C CD1 . ILE A 1 270 ? 109.885 102.220 131.767 1.00 68.69  ? 270 ILE A CD1 1 
ATOM   1600 N N   . THR A 1 271 ? 112.834 105.476 130.372 1.00 71.92  ? 271 THR A N   1 
ATOM   1601 C CA  . THR A 1 271 ? 114.178 105.323 129.826 1.00 71.92  ? 271 THR A CA  1 
ATOM   1602 C C   . THR A 1 271 ? 114.927 106.645 129.823 1.00 71.92  ? 271 THR A C   1 
ATOM   1603 O O   . THR A 1 271 ? 116.155 106.639 129.920 1.00 71.92  ? 271 THR A O   1 
ATOM   1604 C CB  . THR A 1 271 ? 114.156 104.708 128.418 1.00 71.92  ? 271 THR A CB  1 
ATOM   1605 O OG1 . THR A 1 271 ? 115.475 104.266 128.080 1.00 71.92  ? 271 THR A OG1 1 
ATOM   1606 C CG2 . THR A 1 271 ? 113.723 105.701 127.351 1.00 71.92  ? 271 THR A CG2 1 
ATOM   1607 N N   . THR A 1 272 ? 114.213 107.771 129.838 1.00 74.52  ? 272 THR A N   1 
ATOM   1608 C CA  . THR A 1 272 ? 114.862 109.066 129.929 1.00 74.52  ? 272 THR A CA  1 
ATOM   1609 C C   . THR A 1 272 ? 115.381 109.323 131.333 1.00 74.52  ? 272 THR A C   1 
ATOM   1610 O O   . THR A 1 272 ? 116.507 109.805 131.500 1.00 74.52  ? 272 THR A O   1 
ATOM   1611 C CB  . THR A 1 272 ? 113.877 110.150 129.527 1.00 74.52  ? 272 THR A CB  1 
ATOM   1612 O OG1 . THR A 1 272 ? 113.324 109.818 128.251 1.00 74.52  ? 272 THR A OG1 1 
ATOM   1613 C CG2 . THR A 1 272 ? 114.577 111.481 129.442 1.00 74.52  ? 272 THR A CG2 1 
ATOM   1614 N N   . THR A 1 273 ? 114.578 108.992 132.350 1.00 77.45  ? 273 THR A N   1 
ATOM   1615 C CA  . THR A 1 273 ? 115.038 109.138 133.727 1.00 77.45  ? 273 THR A CA  1 
ATOM   1616 C C   . THR A 1 273 ? 116.200 108.194 134.020 1.00 77.45  ? 273 THR A C   1 
ATOM   1617 O O   . THR A 1 273 ? 117.172 108.585 134.680 1.00 77.45  ? 273 THR A O   1 
ATOM   1618 C CB  . THR A 1 273 ? 113.873 108.906 134.689 1.00 77.45  ? 273 THR A CB  1 
ATOM   1619 O OG1 . THR A 1 273 ? 112.818 109.822 134.376 1.00 77.45  ? 273 THR A OG1 1 
ATOM   1620 C CG2 . THR A 1 273 ? 114.300 109.145 136.129 1.00 77.45  ? 273 THR A CG2 1 
ATOM   1621 N N   . LEU A 1 274 ? 116.158 106.973 133.473 1.00 78.62  ? 274 LEU A N   1 
ATOM   1622 C CA  . LEU A 1 274 ? 117.274 106.050 133.667 1.00 78.62  ? 274 LEU A CA  1 
ATOM   1623 C C   . LEU A 1 274 ? 118.537 106.502 132.932 1.00 78.62  ? 274 LEU A C   1 
ATOM   1624 O O   . LEU A 1 274 ? 119.633 106.435 133.498 1.00 78.62  ? 274 LEU A O   1 
ATOM   1625 C CB  . LEU A 1 274 ? 116.873 104.635 133.255 1.00 78.62  ? 274 LEU A CB  1 
ATOM   1626 C CG  . LEU A 1 274 ? 116.367 103.722 134.379 1.00 78.62  ? 274 LEU A CG  1 
ATOM   1627 C CD1 . LEU A 1 274 ? 115.058 104.171 135.001 1.00 78.62  ? 274 LEU A CD1 1 
ATOM   1628 C CD2 . LEU A 1 274 ? 116.233 102.306 133.851 1.00 78.62  ? 274 LEU A CD2 1 
ATOM   1629 N N   . VAL A 1 275 ? 118.415 107.004 131.699 1.00 75.61  ? 275 VAL A N   1 
ATOM   1630 C CA  . VAL A 1 275 ? 119.615 107.429 130.981 1.00 75.61  ? 275 VAL A CA  1 
ATOM   1631 C C   . VAL A 1 275 ? 120.127 108.774 131.496 1.00 75.61  ? 275 VAL A C   1 
ATOM   1632 O O   . VAL A 1 275 ? 121.297 109.112 131.279 1.00 75.61  ? 275 VAL A O   1 
ATOM   1633 C CB  . VAL A 1 275 ? 119.347 107.459 129.462 1.00 75.61  ? 275 VAL A CB  1 
ATOM   1634 C CG1 . VAL A 1 275 ? 118.547 108.674 129.056 1.00 75.61  ? 275 VAL A CG1 1 
ATOM   1635 C CG2 . VAL A 1 275 ? 120.634 107.344 128.654 1.00 75.61  ? 275 VAL A CG2 1 
ATOM   1636 N N   . ALA A 1 276 ? 119.300 109.537 132.213 1.00 79.92  ? 276 ALA A N   1 
ATOM   1637 C CA  . ALA A 1 276 ? 119.788 110.763 132.828 1.00 79.92  ? 276 ALA A CA  1 
ATOM   1638 C C   . ALA A 1 276 ? 120.432 110.508 134.183 1.00 79.92  ? 276 ALA A C   1 
ATOM   1639 O O   . ALA A 1 276 ? 121.387 111.202 134.545 1.00 79.92  ? 276 ALA A O   1 
ATOM   1640 C CB  . ALA A 1 276 ? 118.648 111.770 132.971 1.00 79.92  ? 276 ALA A CB  1 
ATOM   1641 N N   . LEU A 1 277 ? 119.935 109.533 134.944 1.00 83.93  ? 277 LEU A N   1 
ATOM   1642 C CA  . LEU A 1 277 ? 120.486 109.260 136.264 1.00 83.93  ? 277 LEU A CA  1 
ATOM   1643 C C   . LEU A 1 277 ? 121.535 108.155 136.273 1.00 83.93  ? 277 LEU A C   1 
ATOM   1644 O O   . LEU A 1 277 ? 122.148 107.922 137.319 1.00 83.93  ? 277 LEU A O   1 
ATOM   1645 C CB  . LEU A 1 277 ? 119.369 108.899 137.253 1.00 83.93  ? 277 LEU A CB  1 
ATOM   1646 C CG  . LEU A 1 277 ? 118.636 110.027 137.990 1.00 83.93  ? 277 LEU A CG  1 
ATOM   1647 C CD1 . LEU A 1 277 ? 117.688 110.811 137.095 1.00 83.93  ? 277 LEU A CD1 1 
ATOM   1648 C CD2 . LEU A 1 277 ? 117.890 109.465 139.192 1.00 83.93  ? 277 LEU A CD2 1 
ATOM   1649 N N   . LEU A 1 278 ? 121.759 107.471 135.156 1.00 86.06  ? 278 LEU A N   1 
ATOM   1650 C CA  . LEU A 1 278 ? 122.790 106.444 135.114 1.00 86.06  ? 278 LEU A CA  1 
ATOM   1651 C C   . LEU A 1 278 ? 123.704 106.635 133.908 1.00 86.06  ? 278 LEU A C   1 
ATOM   1652 O O   . LEU A 1 278 ? 124.814 107.153 134.033 1.00 86.06  ? 278 LEU A O   1 
ATOM   1653 C CB  . LEU A 1 278 ? 122.157 105.050 135.077 1.00 86.06  ? 278 LEU A CB  1 
ATOM   1654 C CG  . LEU A 1 278 ? 121.352 104.606 136.303 1.00 86.06  ? 278 LEU A CG  1 
ATOM   1655 C CD1 . LEU A 1 278 ? 120.691 103.257 136.058 1.00 86.06  ? 278 LEU A CD1 1 
ATOM   1656 C CD2 . LEU A 1 278 ? 122.226 104.560 137.546 1.00 86.06  ? 278 LEU A CD2 1 
ATOM   1657 N N   . ILE A 1 294 ? 125.240 128.515 116.304 1.00 113.21 ? 294 ILE A N   1 
ATOM   1658 C CA  . ILE A 1 294 ? 126.395 129.112 115.651 1.00 113.21 ? 294 ILE A CA  1 
ATOM   1659 C C   . ILE A 1 294 ? 126.081 129.217 114.153 1.00 113.21 ? 294 ILE A C   1 
ATOM   1660 O O   . ILE A 1 294 ? 125.262 128.459 113.630 1.00 113.21 ? 294 ILE A O   1 
ATOM   1661 C CB  . ILE A 1 294 ? 127.685 128.297 115.959 1.00 113.21 ? 294 ILE A CB  1 
ATOM   1662 C CG1 . ILE A 1 294 ? 128.948 129.106 115.649 1.00 113.21 ? 294 ILE A CG1 1 
ATOM   1663 C CG2 . ILE A 1 294 ? 127.686 126.962 115.227 1.00 113.21 ? 294 ILE A CG2 1 
ATOM   1664 C CD1 . ILE A 1 294 ? 129.128 130.320 116.530 1.00 113.21 ? 294 ILE A CD1 1 
ATOM   1665 N N   . THR A 1 295 ? 126.699 130.184 113.471 1.00 114.18 ? 295 THR A N   1 
ATOM   1666 C CA  . THR A 1 295 ? 126.379 130.476 112.082 1.00 114.18 ? 295 THR A CA  1 
ATOM   1667 C C   . THR A 1 295 ? 127.465 130.073 111.096 1.00 114.18 ? 295 THR A C   1 
ATOM   1668 O O   . THR A 1 295 ? 127.226 130.143 109.885 1.00 114.18 ? 295 THR A O   1 
ATOM   1669 C CB  . THR A 1 295 ? 126.088 131.974 111.905 1.00 114.18 ? 295 THR A CB  1 
ATOM   1670 O OG1 . THR A 1 295 ? 127.254 132.732 112.251 1.00 114.18 ? 295 THR A OG1 1 
ATOM   1671 C CG2 . THR A 1 295 ? 124.929 132.400 112.792 1.00 114.18 ? 295 THR A CG2 1 
ATOM   1672 N N   . ASP A 1 296 ? 128.644 129.658 111.571 1.00 114.63 ? 296 ASP A N   1 
ATOM   1673 C CA  . ASP A 1 296 ? 129.714 129.278 110.652 1.00 114.63 ? 296 ASP A CA  1 
ATOM   1674 C C   . ASP A 1 296 ? 129.391 127.987 109.909 1.00 114.63 ? 296 ASP A C   1 
ATOM   1675 O O   . ASP A 1 296 ? 129.768 127.835 108.742 1.00 114.63 ? 296 ASP A O   1 
ATOM   1676 C CB  . ASP A 1 296 ? 131.046 129.164 111.403 1.00 114.63 ? 296 ASP A CB  1 
ATOM   1677 C CG  . ASP A 1 296 ? 131.004 128.172 112.562 1.00 114.63 ? 296 ASP A CG  1 
ATOM   1678 O OD1 . ASP A 1 296 ? 129.927 127.622 112.869 1.00 114.63 ? 296 ASP A OD1 1 
ATOM   1679 O OD2 . ASP A 1 296 ? 132.068 127.943 113.174 1.00 114.63 ? 296 ASP A OD2 1 
ATOM   1680 N N   . THR A 1 297 ? 128.666 127.069 110.552 1.00 111.47 ? 297 THR A N   1 
ATOM   1681 C CA  . THR A 1 297 ? 128.256 125.841 109.880 1.00 111.47 ? 297 THR A CA  1 
ATOM   1682 C C   . THR A 1 297 ? 127.213 126.129 108.804 1.00 111.47 ? 297 THR A C   1 
ATOM   1683 O O   . THR A 1 297 ? 127.248 125.534 107.722 1.00 111.47 ? 297 THR A O   1 
ATOM   1684 C CB  . THR A 1 297 ? 127.726 124.839 110.908 1.00 111.47 ? 297 THR A CB  1 
ATOM   1685 O OG1 . THR A 1 297 ? 128.714 124.642 111.926 1.00 111.47 ? 297 THR A OG1 1 
ATOM   1686 C CG2 . THR A 1 297 ? 127.438 123.493 110.257 1.00 111.47 ? 297 THR A CG2 1 
ATOM   1687 N N   . TYR A 1 298 ? 126.303 127.072 109.064 1.00 105.52 ? 298 TYR A N   1 
ATOM   1688 C CA  . TYR A 1 298 ? 125.348 127.470 108.034 1.00 105.52 ? 298 TYR A CA  1 
ATOM   1689 C C   . TYR A 1 298 ? 126.021 128.228 106.896 1.00 105.52 ? 298 TYR A C   1 
ATOM   1690 O O   . TYR A 1 298 ? 125.609 128.087 105.739 1.00 105.52 ? 298 TYR A O   1 
ATOM   1691 C CB  . TYR A 1 298 ? 124.228 128.311 108.642 1.00 105.52 ? 298 TYR A CB  1 
ATOM   1692 C CG  . TYR A 1 298 ? 123.277 127.524 109.508 1.00 105.52 ? 298 TYR A CG  1 
ATOM   1693 C CD1 . TYR A 1 298 ? 122.283 126.739 108.938 1.00 105.52 ? 298 TYR A CD1 1 
ATOM   1694 C CD2 . TYR A 1 298 ? 123.364 127.572 110.894 1.00 105.52 ? 298 TYR A CD2 1 
ATOM   1695 C CE1 . TYR A 1 298 ? 121.406 126.018 109.721 1.00 105.52 ? 298 TYR A CE1 1 
ATOM   1696 C CE2 . TYR A 1 298 ? 122.488 126.855 111.687 1.00 105.52 ? 298 TYR A CE2 1 
ATOM   1697 C CZ  . TYR A 1 298 ? 121.513 126.080 111.092 1.00 105.52 ? 298 TYR A CZ  1 
ATOM   1698 O OH  . TYR A 1 298 ? 120.638 125.362 111.871 1.00 105.52 ? 298 TYR A OH  1 
ATOM   1699 N N   . LYS A 1 299 ? 127.055 129.019 107.194 1.00 109.25 ? 299 LYS A N   1 
ATOM   1700 C CA  . LYS A 1 299 ? 127.829 129.651 106.127 1.00 109.25 ? 299 LYS A CA  1 
ATOM   1701 C C   . LYS A 1 299 ? 128.578 128.610 105.302 1.00 109.25 ? 299 LYS A C   1 
ATOM   1702 O O   . LYS A 1 299 ? 128.706 128.750 104.079 1.00 109.25 ? 299 LYS A O   1 
ATOM   1703 C CB  . LYS A 1 299 ? 128.803 130.673 106.711 1.00 109.25 ? 299 LYS A CB  1 
ATOM   1704 C CG  . LYS A 1 299 ? 128.139 131.919 107.273 1.00 109.25 ? 299 LYS A CG  1 
ATOM   1705 C CD  . LYS A 1 299 ? 129.166 132.882 107.846 1.00 109.25 ? 299 LYS A CD  1 
ATOM   1706 C CE  . LYS A 1 299 ? 128.496 134.108 108.443 1.00 109.25 ? 299 LYS A CE  1 
ATOM   1707 N NZ  . LYS A 1 299 ? 129.486 135.049 109.032 1.00 109.25 ? 299 LYS A NZ  1 
ATOM   1708 N N   . LEU A 1 300 ? 129.050 127.545 105.958 1.00 108.50 ? 300 LEU A N   1 
ATOM   1709 C CA  . LEU A 1 300 ? 129.683 126.438 105.250 1.00 108.50 ? 300 LEU A CA  1 
ATOM   1710 C C   . LEU A 1 300 ? 128.688 125.719 104.346 1.00 108.50 ? 300 LEU A C   1 
ATOM   1711 O O   . LEU A 1 300 ? 129.019 125.372 103.209 1.00 108.50 ? 300 LEU A O   1 
ATOM   1712 C CB  . LEU A 1 300 ? 130.310 125.476 106.264 1.00 108.50 ? 300 LEU A CB  1 
ATOM   1713 C CG  . LEU A 1 300 ? 131.212 124.320 105.825 1.00 108.50 ? 300 LEU A CG  1 
ATOM   1714 C CD1 . LEU A 1 300 ? 132.293 124.105 106.866 1.00 108.50 ? 300 LEU A CD1 1 
ATOM   1715 C CD2 . LEU A 1 300 ? 130.422 123.034 105.654 1.00 108.50 ? 300 LEU A CD2 1 
ATOM   1716 N N   . LEU A 1 301 ? 127.465 125.494 104.835 1.00 103.39 ? 301 LEU A N   1 
ATOM   1717 C CA  . LEU A 1 301 ? 126.432 124.861 104.018 1.00 103.39 ? 301 LEU A CA  1 
ATOM   1718 C C   . LEU A 1 301 ? 126.014 125.745 102.851 1.00 103.39 ? 301 LEU A C   1 
ATOM   1719 O O   . LEU A 1 301 ? 125.718 125.235 101.763 1.00 103.39 ? 301 LEU A O   1 
ATOM   1720 C CB  . LEU A 1 301 ? 125.217 124.524 104.878 1.00 103.39 ? 301 LEU A CB  1 
ATOM   1721 C CG  . LEU A 1 301 ? 125.399 123.453 105.949 1.00 103.39 ? 301 LEU A CG  1 
ATOM   1722 C CD1 . LEU A 1 301 ? 124.205 123.455 106.872 1.00 103.39 ? 301 LEU A CD1 1 
ATOM   1723 C CD2 . LEU A 1 301 ? 125.575 122.091 105.320 1.00 103.39 ? 301 LEU A CD2 1 
ATOM   1724 N N   . PHE A 1 302 ? 125.998 127.065 103.053 1.00 107.96 ? 302 PHE A N   1 
ATOM   1725 C CA  . PHE A 1 302 ? 125.711 127.986 101.959 1.00 107.96 ? 302 PHE A CA  1 
ATOM   1726 C C   . PHE A 1 302 ? 126.822 127.964 100.917 1.00 107.96 ? 302 PHE A C   1 
ATOM   1727 O O   . PHE A 1 302 ? 126.548 128.021 99.713  1.00 107.96 ? 302 PHE A O   1 
ATOM   1728 C CB  . PHE A 1 302 ? 125.508 129.399 102.503 1.00 107.96 ? 302 PHE A CB  1 
ATOM   1729 C CG  . PHE A 1 302 ? 125.128 130.407 101.456 1.00 107.96 ? 302 PHE A CG  1 
ATOM   1730 C CD1 . PHE A 1 302 ? 123.840 130.441 100.945 1.00 107.96 ? 302 PHE A CD1 1 
ATOM   1731 C CD2 . PHE A 1 302 ? 126.056 131.328 100.991 1.00 107.96 ? 302 PHE A CD2 1 
ATOM   1732 C CE1 . PHE A 1 302 ? 123.484 131.372 99.984  1.00 107.96 ? 302 PHE A CE1 1 
ATOM   1733 C CE2 . PHE A 1 302 ? 125.708 132.261 100.029 1.00 107.96 ? 302 PHE A CE2 1 
ATOM   1734 C CZ  . PHE A 1 302 ? 124.420 132.282 99.526  1.00 107.96 ? 302 PHE A CZ  1 
ATOM   1735 N N   . ALA A 1 303 ? 128.079 127.847 101.358 1.00 105.75 ? 303 ALA A N   1 
ATOM   1736 C CA  . ALA A 1 303 ? 129.191 127.725 100.416 1.00 105.75 ? 303 ALA A CA  1 
ATOM   1737 C C   . ALA A 1 303 ? 129.129 126.409 99.645  1.00 105.75 ? 303 ALA A C   1 
ATOM   1738 O O   . ALA A 1 303 ? 129.415 126.373 98.438  1.00 105.75 ? 303 ALA A O   1 
ATOM   1739 C CB  . ALA A 1 303 ? 130.522 127.850 101.155 1.00 105.75 ? 303 ALA A CB  1 
ATOM   1740 N N   . ILE A 1 304 ? 128.735 125.325 100.320 1.00 102.54 ? 304 ILE A N   1 
ATOM   1741 C CA  . ILE A 1 304 ? 128.601 124.033 99.650  1.00 102.54 ? 304 ILE A CA  1 
ATOM   1742 C C   . ILE A 1 304 ? 127.488 124.076 98.609  1.00 102.54 ? 304 ILE A C   1 
ATOM   1743 O O   . ILE A 1 304 ? 127.698 123.709 97.451  1.00 102.54 ? 304 ILE A O   1 
ATOM   1744 C CB  . ILE A 1 304 ? 128.376 122.903 100.669 1.00 102.54 ? 304 ILE A CB  1 
ATOM   1745 C CG1 . ILE A 1 304 ? 129.624 122.683 101.524 1.00 102.54 ? 304 ILE A CG1 1 
ATOM   1746 C CG2 . ILE A 1 304 ? 128.026 121.632 99.953  1.00 102.54 ? 304 ILE A CG2 1 
ATOM   1747 C CD1 . ILE A 1 304 ? 130.843 122.263 100.735 1.00 102.54 ? 304 ILE A CD1 1 
ATOM   1748 N N   . ILE A 1 305 ? 126.310 124.583 98.979  1.00 100.34 ? 305 ILE A N   1 
ATOM   1749 C CA  . ILE A 1 305 ? 125.220 124.651 98.007  1.00 100.34 ? 305 ILE A CA  1 
ATOM   1750 C C   . ILE A 1 305 ? 125.486 125.724 96.941  1.00 100.34 ? 305 ILE A C   1 
ATOM   1751 O O   . ILE A 1 305 ? 124.858 125.711 95.876  1.00 100.34 ? 305 ILE A O   1 
ATOM   1752 C CB  . ILE A 1 305 ? 123.881 124.853 98.749  1.00 100.34 ? 305 ILE A CB  1 
ATOM   1753 C CG1 . ILE A 1 305 ? 122.691 124.435 97.879  1.00 100.34 ? 305 ILE A CG1 1 
ATOM   1754 C CG2 . ILE A 1 305 ? 123.722 126.293 99.206  1.00 100.34 ? 305 ILE A CG2 1 
ATOM   1755 C CD1 . ILE A 1 305 ? 121.395 124.289 98.640  1.00 100.34 ? 305 ILE A CD1 1 
ATOM   1756 N N   . LYS A 1 306 ? 126.441 126.629 97.181  1.00 104.06 ? 306 LYS A N   1 
ATOM   1757 C CA  . LYS A 1 306 ? 126.929 127.521 96.137  1.00 104.06 ? 306 LYS A CA  1 
ATOM   1758 C C   . LYS A 1 306 ? 127.873 126.808 95.168  1.00 104.06 ? 306 LYS A C   1 
ATOM   1759 O O   . LYS A 1 306 ? 127.954 127.203 93.997  1.00 104.06 ? 306 LYS A O   1 
ATOM   1760 C CB  . LYS A 1 306 ? 127.621 128.727 96.789  1.00 104.06 ? 306 LYS A CB  1 
ATOM   1761 C CG  . LYS A 1 306 ? 128.106 129.825 95.846  1.00 104.06 ? 306 LYS A CG  1 
ATOM   1762 C CD  . LYS A 1 306 ? 126.947 130.583 95.219  1.00 104.06 ? 306 LYS A CD  1 
ATOM   1763 C CE  . LYS A 1 306 ? 127.445 131.750 94.380  1.00 104.06 ? 306 LYS A CE  1 
ATOM   1764 N NZ  . LYS A 1 306 ? 126.329 132.468 93.706  1.00 104.06 ? 306 LYS A NZ  1 
ATOM   1765 N N   . MET A 1 307 ? 128.589 125.777 95.635  1.00 100.76 ? 307 MET A N   1 
ATOM   1766 C CA  . MET A 1 307 ? 129.504 125.035 94.763  1.00 100.76 ? 307 MET A CA  1 
ATOM   1767 C C   . MET A 1 307 ? 128.747 124.339 93.627  1.00 100.76 ? 307 MET A C   1 
ATOM   1768 O O   . MET A 1 307 ? 127.692 123.728 93.861  1.00 100.76 ? 307 MET A O   1 
ATOM   1769 C CB  . MET A 1 307 ? 130.310 123.998 95.550  1.00 100.76 ? 307 MET A CB  1 
ATOM   1770 C CG  . MET A 1 307 ? 131.374 124.554 96.479  1.00 100.76 ? 307 MET A CG  1 
ATOM   1771 S SD  . MET A 1 307 ? 132.261 123.224 97.321  1.00 100.76 ? 307 MET A SD  1 
ATOM   1772 C CE  . MET A 1 307 ? 133.360 124.144 98.394  1.00 100.76 ? 307 MET A CE  1 
ATOM   1773 N N   . PRO A 1 308 ? 129.273 124.390 92.394  1.00 97.34  ? 308 PRO A N   1 
ATOM   1774 C CA  . PRO A 1 308 ? 128.426 124.115 91.217  1.00 97.34  ? 308 PRO A CA  1 
ATOM   1775 C C   . PRO A 1 308 ? 128.057 122.656 91.012  1.00 97.34  ? 308 PRO A C   1 
ATOM   1776 O O   . PRO A 1 308 ? 126.910 122.372 90.650  1.00 97.34  ? 308 PRO A O   1 
ATOM   1777 C CB  . PRO A 1 308 ? 129.279 124.638 90.051  1.00 97.34  ? 308 PRO A CB  1 
ATOM   1778 C CG  . PRO A 1 308 ? 130.257 125.578 90.670  1.00 97.34  ? 308 PRO A CG  1 
ATOM   1779 C CD  . PRO A 1 308 ? 130.561 124.987 92.007  1.00 97.34  ? 308 PRO A CD  1 
ATOM   1780 N N   . ALA A 1 309 ? 128.995 121.723 91.205  1.00 90.81  ? 309 ALA A N   1 
ATOM   1781 C CA  . ALA A 1 309 ? 128.715 120.319 90.906  1.00 90.81  ? 309 ALA A CA  1 
ATOM   1782 C C   . ALA A 1 309 ? 127.721 119.726 91.896  1.00 90.81  ? 309 ALA A C   1 
ATOM   1783 O O   . ALA A 1 309 ? 126.785 119.016 91.505  1.00 90.81  ? 309 ALA A O   1 
ATOM   1784 C CB  . ALA A 1 309 ? 130.013 119.515 90.903  1.00 90.81  ? 309 ALA A CB  1 
ATOM   1785 N N   . VAL A 1 310 ? 127.893 120.029 93.181  1.00 93.15  ? 310 VAL A N   1 
ATOM   1786 C CA  . VAL A 1 310 ? 126.939 119.581 94.181  1.00 93.15  ? 310 VAL A CA  1 
ATOM   1787 C C   . VAL A 1 310 ? 125.627 120.364 94.094  1.00 93.15  ? 310 VAL A C   1 
ATOM   1788 O O   . VAL A 1 310 ? 124.572 119.823 94.434  1.00 93.15  ? 310 VAL A O   1 
ATOM   1789 C CB  . VAL A 1 310 ? 127.642 119.642 95.553  1.00 93.15  ? 310 VAL A CB  1 
ATOM   1790 C CG1 . VAL A 1 310 ? 128.154 121.010 95.797  1.00 93.15  ? 310 VAL A CG1 1 
ATOM   1791 C CG2 . VAL A 1 310 ? 126.739 119.196 96.693  1.00 93.15  ? 310 VAL A CG2 1 
ATOM   1792 N N   . LEU A 1 311 ? 125.640 121.596 93.567  1.00 92.71  ? 311 LEU A N   1 
ATOM   1793 C CA  . LEU A 1 311 ? 124.375 122.269 93.260  1.00 92.71  ? 311 LEU A CA  1 
ATOM   1794 C C   . LEU A 1 311 ? 123.631 121.569 92.125  1.00 92.71  ? 311 LEU A C   1 
ATOM   1795 O O   . LEU A 1 311 ? 122.395 121.461 92.152  1.00 92.71  ? 311 LEU A O   1 
ATOM   1796 C CB  . LEU A 1 311 ? 124.631 123.734 92.907  1.00 92.71  ? 311 LEU A CB  1 
ATOM   1797 C CG  . LEU A 1 311 ? 123.406 124.587 92.568  1.00 92.71  ? 311 LEU A CG  1 
ATOM   1798 C CD1 . LEU A 1 311 ? 122.459 124.663 93.752  1.00 92.71  ? 311 LEU A CD1 1 
ATOM   1799 C CD2 . LEU A 1 311 ? 123.821 125.979 92.126  1.00 92.71  ? 311 LEU A CD2 1 
ATOM   1800 N N   . THR A 1 312 ? 124.373 121.084 91.126  1.00 89.85  ? 312 THR A N   1 
ATOM   1801 C CA  . THR A 1 312 ? 123.770 120.317 90.041  1.00 89.85  ? 312 THR A CA  1 
ATOM   1802 C C   . THR A 1 312 ? 123.201 119.000 90.555  1.00 89.85  ? 312 THR A C   1 
ATOM   1803 O O   . THR A 1 312 ? 122.092 118.609 90.176  1.00 89.85  ? 312 THR A O   1 
ATOM   1804 C CB  . THR A 1 312 ? 124.802 120.074 88.938  1.00 89.85  ? 312 THR A CB  1 
ATOM   1805 O OG1 . THR A 1 312 ? 125.299 121.333 88.467  1.00 89.85  ? 312 THR A OG1 1 
ATOM   1806 C CG2 . THR A 1 312 ? 124.185 119.329 87.767  1.00 89.85  ? 312 THR A CG2 1 
ATOM   1807 N N   . PHE A 1 313 ? 123.930 118.328 91.453  1.00 85.21  ? 313 PHE A N   1 
ATOM   1808 C CA  . PHE A 1 313 ? 123.399 117.129 92.103  1.00 85.21  ? 313 PHE A CA  1 
ATOM   1809 C C   . PHE A 1 313 ? 122.172 117.436 92.958  1.00 85.21  ? 313 PHE A C   1 
ATOM   1810 O O   . PHE A 1 313 ? 121.256 116.612 93.033  1.00 85.21  ? 313 PHE A O   1 
ATOM   1811 C CB  . PHE A 1 313 ? 124.474 116.461 92.960  1.00 85.21  ? 313 PHE A CB  1 
ATOM   1812 C CG  . PHE A 1 313 ? 123.984 115.253 93.710  1.00 85.21  ? 313 PHE A CG  1 
ATOM   1813 C CD1 . PHE A 1 313 ? 123.783 114.052 93.059  1.00 85.21  ? 313 PHE A CD1 1 
ATOM   1814 C CD2 . PHE A 1 313 ? 123.717 115.323 95.068  1.00 85.21  ? 313 PHE A CD2 1 
ATOM   1815 C CE1 . PHE A 1 313 ? 123.327 112.943 93.749  1.00 85.21  ? 313 PHE A CE1 1 
ATOM   1816 C CE2 . PHE A 1 313 ? 123.260 114.220 95.761  1.00 85.21  ? 313 PHE A CE2 1 
ATOM   1817 C CZ  . PHE A 1 313 ? 123.066 113.029 95.099  1.00 85.21  ? 313 PHE A CZ  1 
ATOM   1818 N N   . CYS A 1 314 ? 122.140 118.609 93.598  1.00 87.95  ? 314 CYS A N   1 
ATOM   1819 C CA  . CYS A 1 314 ? 120.987 119.030 94.390  1.00 87.95  ? 314 CYS A CA  1 
ATOM   1820 C C   . CYS A 1 314 ? 119.742 119.186 93.526  1.00 87.95  ? 314 CYS A C   1 
ATOM   1821 O O   . CYS A 1 314 ? 118.680 118.634 93.842  1.00 87.95  ? 314 CYS A O   1 
ATOM   1822 C CB  . CYS A 1 314 ? 121.318 120.340 95.105  1.00 87.95  ? 314 CYS A CB  1 
ATOM   1823 S SG  . CYS A 1 314 ? 119.944 121.128 95.960  1.00 87.95  ? 314 CYS A SG  1 
ATOM   1824 N N   . LEU A 1 315 ? 119.863 119.922 92.416  1.00 82.71  ? 315 LEU A N   1 
ATOM   1825 C CA  . LEU A 1 315 ? 118.722 120.106 91.519  1.00 82.71  ? 315 LEU A CA  1 
ATOM   1826 C C   . LEU A 1 315 ? 118.307 118.788 90.870  1.00 82.71  ? 315 LEU A C   1 
ATOM   1827 O O   . LEU A 1 315 ? 117.107 118.517 90.721  1.00 82.71  ? 315 LEU A O   1 
ATOM   1828 C CB  . LEU A 1 315 ? 119.055 121.164 90.464  1.00 82.71  ? 315 LEU A CB  1 
ATOM   1829 C CG  . LEU A 1 315 ? 117.969 121.734 89.544  1.00 82.71  ? 315 LEU A CG  1 
ATOM   1830 C CD1 . LEU A 1 315 ? 118.267 123.196 89.277  1.00 82.71  ? 315 LEU A CD1 1 
ATOM   1831 C CD2 . LEU A 1 315 ? 117.878 120.996 88.212  1.00 82.71  ? 315 LEU A CD2 1 
ATOM   1832 N N   . LEU A 1 316 ? 119.285 117.943 90.525  1.00 79.07  ? 316 LEU A N   1 
ATOM   1833 C CA  . LEU A 1 316 ? 118.994 116.644 89.926  1.00 79.07  ? 316 LEU A CA  1 
ATOM   1834 C C   . LEU A 1 316 ? 118.266 115.719 90.893  1.00 79.07  ? 316 LEU A C   1 
ATOM   1835 O O   . LEU A 1 316 ? 117.303 115.054 90.503  1.00 79.07  ? 316 LEU A O   1 
ATOM   1836 C CB  . LEU A 1 316 ? 120.286 115.996 89.433  1.00 79.07  ? 316 LEU A CB  1 
ATOM   1837 C CG  . LEU A 1 316 ? 120.685 116.106 87.959  1.00 79.07  ? 316 LEU A CG  1 
ATOM   1838 C CD1 . LEU A 1 316 ? 119.734 115.273 87.151  1.00 79.07  ? 316 LEU A CD1 1 
ATOM   1839 C CD2 . LEU A 1 316 ? 120.670 117.526 87.439  1.00 79.07  ? 316 LEU A CD2 1 
ATOM   1840 N N   . ILE A 1 317 ? 118.683 115.670 92.158  1.00 76.69  ? 317 ILE A N   1 
ATOM   1841 C CA  . ILE A 1 317 ? 118.023 114.757 93.081  1.00 76.69  ? 317 ILE A CA  1 
ATOM   1842 C C   . ILE A 1 317 ? 116.718 115.348 93.608  1.00 76.69  ? 317 ILE A C   1 
ATOM   1843 O O   . ILE A 1 317 ? 115.881 114.609 94.140  1.00 76.69  ? 317 ILE A O   1 
ATOM   1844 C CB  . ILE A 1 317 ? 118.983 114.358 94.216  1.00 76.69  ? 317 ILE A CB  1 
ATOM   1845 C CG1 . ILE A 1 317 ? 118.574 113.016 94.823  1.00 76.69  ? 317 ILE A CG1 1 
ATOM   1846 C CG2 . ILE A 1 317 ? 119.026 115.420 95.296  1.00 76.69  ? 317 ILE A CG2 1 
ATOM   1847 C CD1 . ILE A 1 317 ? 118.666 111.872 93.852  1.00 76.69  ? 317 ILE A CD1 1 
ATOM   1848 N N   . LEU A 1 318 ? 116.493 116.655 93.450  1.00 77.24  ? 318 LEU A N   1 
ATOM   1849 C CA  . LEU A 1 318 ? 115.146 117.171 93.681  1.00 77.24  ? 318 LEU A CA  1 
ATOM   1850 C C   . LEU A 1 318 ? 114.199 116.781 92.554  1.00 77.24  ? 318 LEU A C   1 
ATOM   1851 O O   . LEU A 1 318 ? 113.080 116.324 92.810  1.00 77.24  ? 318 LEU A O   1 
ATOM   1852 C CB  . LEU A 1 318 ? 115.165 118.685 93.878  1.00 77.24  ? 318 LEU A CB  1 
ATOM   1853 C CG  . LEU A 1 318 ? 115.101 119.154 95.333  1.00 77.24  ? 318 LEU A CG  1 
ATOM   1854 C CD1 . LEU A 1 318 ? 116.306 118.752 96.112  1.00 77.24  ? 318 LEU A CD1 1 
ATOM   1855 C CD2 . LEU A 1 318 ? 114.928 120.662 95.384  1.00 77.24  ? 318 LEU A CD2 1 
ATOM   1856 N N   . THR A 1 319 ? 114.619 116.940 91.299  1.00 74.55  ? 319 THR A N   1 
ATOM   1857 C CA  . THR A 1 319 ? 113.710 116.618 90.203  1.00 74.55  ? 319 THR A CA  1 
ATOM   1858 C C   . THR A 1 319 ? 113.764 115.154 89.775  1.00 74.55  ? 319 THR A C   1 
ATOM   1859 O O   . THR A 1 319 ? 113.088 114.783 88.811  1.00 74.55  ? 319 THR A O   1 
ATOM   1860 C CB  . THR A 1 319 ? 113.979 117.516 88.991  1.00 74.55  ? 319 THR A CB  1 
ATOM   1861 O OG1 . THR A 1 319 ? 112.939 117.328 88.024  1.00 74.55  ? 319 THR A OG1 1 
ATOM   1862 C CG2 . THR A 1 319 ? 115.308 117.177 88.349  1.00 74.55  ? 319 THR A CG2 1 
ATOM   1863 N N   . ALA A 1 320 ? 114.536 114.315 90.469  1.00 73.54  ? 320 ALA A N   1 
ATOM   1864 C CA  . ALA A 1 320 ? 114.675 112.918 90.072  1.00 73.54  ? 320 ALA A CA  1 
ATOM   1865 C C   . ALA A 1 320 ? 113.501 112.064 90.526  1.00 73.54  ? 320 ALA A C   1 
ATOM   1866 O O   . ALA A 1 320 ? 112.941 111.298 89.736  1.00 73.54  ? 320 ALA A O   1 
ATOM   1867 C CB  . ALA A 1 320 ? 115.972 112.347 90.640  1.00 73.54  ? 320 ALA A CB  1 
ATOM   1868 N N   . LYS A 1 321 ? 113.125 112.167 91.794  1.00 67.38  ? 321 LYS A N   1 
ATOM   1869 C CA  . LYS A 1 321 ? 112.237 111.195 92.408  1.00 67.38  ? 321 LYS A CA  1 
ATOM   1870 C C   . LYS A 1 321 ? 110.760 111.496 92.177  1.00 67.38  ? 321 LYS A C   1 
ATOM   1871 O O   . LYS A 1 321 ? 109.906 110.816 92.760  1.00 67.38  ? 321 LYS A O   1 
ATOM   1872 C CB  . LYS A 1 321 ? 112.552 111.089 93.900  1.00 67.38  ? 321 LYS A CB  1 
ATOM   1873 C CG  . LYS A 1 321 ? 113.936 110.503 94.141  1.00 67.38  ? 321 LYS A CG  1 
ATOM   1874 C CD  . LYS A 1 321 ? 114.223 110.245 95.596  1.00 67.38  ? 321 LYS A CD  1 
ATOM   1875 C CE  . LYS A 1 321 ? 115.602 109.654 95.775  1.00 67.38  ? 321 LYS A CE  1 
ATOM   1876 N NZ  . LYS A 1 321 ? 115.913 109.379 97.200  1.00 67.38  ? 321 LYS A NZ  1 
ATOM   1877 N N   . ILE A 1 322 ? 110.451 112.469 91.312  1.00 66.19  ? 322 ILE A N   1 
ATOM   1878 C CA  . ILE A 1 322 ? 109.072 112.786 90.951  1.00 66.19  ? 322 ILE A CA  1 
ATOM   1879 C C   . ILE A 1 322 ? 108.428 111.617 90.220  1.00 66.19  ? 322 ILE A C   1 
ATOM   1880 O O   . ILE A 1 322 ? 107.220 111.379 90.352  1.00 66.19  ? 322 ILE A O   1 
ATOM   1881 C CB  . ILE A 1 322 ? 109.044 114.066 90.091  1.00 66.19  ? 322 ILE A CB  1 
ATOM   1882 C CG1 . ILE A 1 322 ? 109.762 115.205 90.798  1.00 66.19  ? 322 ILE A CG1 1 
ATOM   1883 C CG2 . ILE A 1 322 ? 107.628 114.529 89.827  1.00 66.19  ? 322 ILE A CG2 1 
ATOM   1884 C CD1 . ILE A 1 322 ? 109.983 116.401 89.910  1.00 66.19  ? 322 ILE A CD1 1 
ATOM   1885 N N   . GLY A 1 323 ? 109.226 110.849 89.475  1.00 70.51  ? 323 GLY A N   1 
ATOM   1886 C CA  . GLY A 1 323 ? 108.678 109.820 88.611  1.00 70.51  ? 323 GLY A CA  1 
ATOM   1887 C C   . GLY A 1 323 ? 108.046 108.656 89.340  1.00 70.51  ? 323 GLY A C   1 
ATOM   1888 O O   . GLY A 1 323 ? 107.095 108.049 88.839  1.00 70.51  ? 323 GLY A O   1 
ATOM   1889 N N   . PHE A 1 324 ? 108.549 108.334 90.521  1.00 71.66  ? 324 PHE A N   1 
ATOM   1890 C CA  . PHE A 1 324 ? 108.024 107.233 91.306  1.00 71.66  ? 324 PHE A CA  1 
ATOM   1891 C C   . PHE A 1 324 ? 107.524 107.646 92.680  1.00 71.66  ? 324 PHE A C   1 
ATOM   1892 O O   . PHE A 1 324 ? 106.998 106.791 93.407  1.00 71.66  ? 324 PHE A O   1 
ATOM   1893 C CB  . PHE A 1 324 ? 109.081 106.132 91.440  1.00 71.66  ? 324 PHE A CB  1 
ATOM   1894 C CG  . PHE A 1 324 ? 110.453 106.649 91.711  1.00 71.66  ? 324 PHE A CG  1 
ATOM   1895 C CD1 . PHE A 1 324 ? 110.801 107.128 92.958  1.00 71.66  ? 324 PHE A CD1 1 
ATOM   1896 C CD2 . PHE A 1 324 ? 111.378 106.724 90.694  1.00 71.66  ? 324 PHE A CD2 1 
ATOM   1897 C CE1 . PHE A 1 324 ? 112.058 107.618 93.185  1.00 71.66  ? 324 PHE A CE1 1 
ATOM   1898 C CE2 . PHE A 1 324 ? 112.627 107.206 90.925  1.00 71.66  ? 324 PHE A CE2 1 
ATOM   1899 C CZ  . PHE A 1 324 ? 112.972 107.655 92.163  1.00 71.66  ? 324 PHE A CZ  1 
ATOM   1900 N N   . SER A 1 325 ? 107.660 108.920 93.060  1.00 72.08  ? 325 SER A N   1 
ATOM   1901 C CA  . SER A 1 325 ? 107.108 109.341 94.336  1.00 72.08  ? 325 SER A CA  1 
ATOM   1902 C C   . SER A 1 325 ? 105.588 109.349 94.328  1.00 72.08  ? 325 SER A C   1 
ATOM   1903 O O   . SER A 1 325 ? 104.986 109.168 95.389  1.00 72.08  ? 325 SER A O   1 
ATOM   1904 C CB  . SER A 1 325 ? 107.650 110.715 94.704  1.00 72.08  ? 325 SER A CB  1 
ATOM   1905 O OG  . SER A 1 325 ? 107.149 111.143 95.954  1.00 72.08  ? 325 SER A OG  1 
ATOM   1906 N N   . ALA A 1 326 ? 104.965 109.496 93.155  1.00 68.88  ? 326 ALA A N   1 
ATOM   1907 C CA  . ALA A 1 326 ? 103.512 109.389 93.057  1.00 68.88  ? 326 ALA A CA  1 
ATOM   1908 C C   . ALA A 1 326 ? 103.034 107.991 93.422  1.00 68.88  ? 326 ALA A C   1 
ATOM   1909 O O   . ALA A 1 326 ? 102.109 107.835 94.224  1.00 68.88  ? 326 ALA A O   1 
ATOM   1910 C CB  . ALA A 1 326 ? 103.053 109.753 91.651  1.00 68.88  ? 326 ALA A CB  1 
ATOM   1911 N N   . ALA A 1 327 ? 103.674 106.963 92.860  1.00 66.96  ? 327 ALA A N   1 
ATOM   1912 C CA  . ALA A 1 327 ? 103.332 105.588 93.211  1.00 66.96  ? 327 ALA A CA  1 
ATOM   1913 C C   . ALA A 1 327 ? 103.642 105.305 94.674  1.00 66.96  ? 327 ALA A C   1 
ATOM   1914 O O   . ALA A 1 327 ? 102.759 104.885 95.432  1.00 66.96  ? 327 ALA A O   1 
ATOM   1915 C CB  . ALA A 1 327 ? 104.077 104.612 92.302  1.00 66.96  ? 327 ALA A CB  1 
ATOM   1916 N N   . ASP A 1 328 ? 104.864 105.641 95.107  1.00 72.48  ? 328 ASP A N   1 
ATOM   1917 C CA  . ASP A 1 328 ? 105.331 105.342 96.457  1.00 72.48  ? 328 ASP A CA  1 
ATOM   1918 C C   . ASP A 1 328 ? 104.570 106.112 97.536  1.00 72.48  ? 328 ASP A C   1 
ATOM   1919 O O   . ASP A 1 328 ? 104.595 105.708 98.702  1.00 72.48  ? 328 ASP A O   1 
ATOM   1920 C CB  . ASP A 1 328 ? 106.826 105.658 96.547  1.00 72.48  ? 328 ASP A CB  1 
ATOM   1921 C CG  . ASP A 1 328 ? 107.529 104.918 97.674  1.00 72.48  ? 328 ASP A CG  1 
ATOM   1922 O OD1 . ASP A 1 328 ? 106.899 104.079 98.351  1.00 72.48  ? 328 ASP A OD1 1 
ATOM   1923 O OD2 . ASP A 1 328 ? 108.731 105.181 97.885  1.00 72.48  ? 328 ASP A OD2 1 
ATOM   1924 N N   . ALA A 1 329 ? 103.877 107.194 97.182  1.00 67.71  ? 329 ALA A N   1 
ATOM   1925 C CA  . ALA A 1 329 ? 103.124 107.966 98.158  1.00 67.71  ? 329 ALA A CA  1 
ATOM   1926 C C   . ALA A 1 329 ? 101.624 107.731 98.114  1.00 67.71  ? 329 ALA A C   1 
ATOM   1927 O O   . ALA A 1 329 ? 100.973 107.813 99.158  1.00 67.71  ? 329 ALA A O   1 
ATOM   1928 C CB  . ALA A 1 329 ? 103.385 109.456 97.957  1.00 67.71  ? 329 ALA A CB  1 
ATOM   1929 N N   . VAL A 1 330 ? 101.047 107.453 96.946  1.00 65.51  ? 330 VAL A N   1 
ATOM   1930 C CA  . VAL A 1 330 ? 99.598  107.376 96.838  1.00 65.51  ? 330 VAL A CA  1 
ATOM   1931 C C   . VAL A 1 330 ? 99.096  105.929 96.799  1.00 65.51  ? 330 VAL A C   1 
ATOM   1932 O O   . VAL A 1 330 ? 97.949  105.681 97.205  1.00 65.51  ? 330 VAL A O   1 
ATOM   1933 C CB  . VAL A 1 330 ? 99.130  108.183 95.602  1.00 65.51  ? 330 VAL A CB  1 
ATOM   1934 C CG1 . VAL A 1 330 ? 97.625  108.326 95.524  1.00 65.51  ? 330 VAL A CG1 1 
ATOM   1935 C CG2 . VAL A 1 330 ? 99.748  109.565 95.616  1.00 65.51  ? 330 VAL A CG2 1 
ATOM   1936 N N   . THR A 1 331 ? 99.938  104.963 96.393  1.00 67.01  ? 331 THR A N   1 
ATOM   1937 C CA  . THR A 1 331 ? 99.479  103.591 96.195  1.00 67.01  ? 331 THR A CA  1 
ATOM   1938 C C   . THR A 1 331 ? 99.080  102.929 97.510  1.00 67.01  ? 331 THR A C   1 
ATOM   1939 O O   . THR A 1 331 ? 98.070  102.215 97.570  1.00 67.01  ? 331 THR A O   1 
ATOM   1940 C CB  . THR A 1 331 ? 100.577 102.792 95.500  1.00 67.01  ? 331 THR A CB  1 
ATOM   1941 O OG1 . THR A 1 331 ? 100.941 103.453 94.284  1.00 67.01  ? 331 THR A OG1 1 
ATOM   1942 C CG2 . THR A 1 331 ? 100.101 101.406 95.161  1.00 67.01  ? 331 THR A CG2 1 
ATOM   1943 N N   . GLY A 1 332 ? 99.820  103.208 98.585  1.00 70.10  ? 332 GLY A N   1 
ATOM   1944 C CA  . GLY A 1 332 ? 99.500  102.661 99.894  1.00 70.10  ? 332 GLY A CA  1 
ATOM   1945 C C   . GLY A 1 332 ? 98.190  103.150 100.477 1.00 70.10  ? 332 GLY A C   1 
ATOM   1946 O O   . GLY A 1 332 ? 97.663  102.524 101.400 1.00 70.10  ? 332 GLY A O   1 
ATOM   1947 N N   . LEU A 1 333 ? 97.651  104.249 99.957  1.00 65.35  ? 333 LEU A N   1 
ATOM   1948 C CA  . LEU A 1 333 ? 96.349  104.741 100.379 1.00 65.35  ? 333 LEU A CA  1 
ATOM   1949 C C   . LEU A 1 333 ? 95.242  104.386 99.401  1.00 65.35  ? 333 LEU A C   1 
ATOM   1950 O O   . LEU A 1 333 ? 94.096  104.175 99.822  1.00 65.35  ? 333 LEU A O   1 
ATOM   1951 C CB  . LEU A 1 333 ? 96.382  106.260 100.562 1.00 65.35  ? 333 LEU A CB  1 
ATOM   1952 C CG  . LEU A 1 333 ? 97.049  106.810 101.823 1.00 65.35  ? 333 LEU A CG  1 
ATOM   1953 C CD1 . LEU A 1 333 ? 98.563  106.912 101.711 1.00 65.35  ? 333 LEU A CD1 1 
ATOM   1954 C CD2 . LEU A 1 333 ? 96.457  108.139 102.151 1.00 65.35  ? 333 LEU A CD2 1 
ATOM   1955 N N   . LYS A 1 334 ? 95.557  104.311 98.105  1.00 66.35  ? 334 LYS A N   1 
ATOM   1956 C CA  . LYS A 1 334 ? 94.563  103.853 97.143  1.00 66.35  ? 334 LYS A CA  1 
ATOM   1957 C C   . LYS A 1 334 ? 94.236  102.386 97.345  1.00 66.35  ? 334 LYS A C   1 
ATOM   1958 O O   . LYS A 1 334 ? 93.104  101.969 97.095  1.00 66.35  ? 334 LYS A O   1 
ATOM   1959 C CB  . LYS A 1 334 ? 95.036  104.088 95.714  1.00 66.35  ? 334 LYS A CB  1 
ATOM   1960 C CG  . LYS A 1 334 ? 95.200  105.539 95.361  1.00 66.35  ? 334 LYS A CG  1 
ATOM   1961 C CD  . LYS A 1 334 ? 93.892  106.275 95.479  1.00 66.35  ? 334 LYS A CD  1 
ATOM   1962 C CE  . LYS A 1 334 ? 92.928  105.839 94.415  1.00 66.35  ? 334 LYS A CE  1 
ATOM   1963 N NZ  . LYS A 1 334 ? 91.665  106.619 94.465  1.00 66.35  ? 334 LYS A NZ  1 
ATOM   1964 N N   . LEU A 1 335 ? 95.194  101.594 97.825  1.00 69.93  ? 335 LEU A N   1 
ATOM   1965 C CA  . LEU A 1 335 ? 94.869  100.223 98.190  1.00 69.93  ? 335 LEU A CA  1 
ATOM   1966 C C   . LEU A 1 335 ? 93.919  100.164 99.384  1.00 69.93  ? 335 LEU A C   1 
ATOM   1967 O O   . LEU A 1 335 ? 93.022  99.312  99.416  1.00 69.93  ? 335 LEU A O   1 
ATOM   1968 C CB  . LEU A 1 335 ? 96.153  99.450  98.460  1.00 69.93  ? 335 LEU A CB  1 
ATOM   1969 C CG  . LEU A 1 335 ? 96.975  99.127  97.218  1.00 69.93  ? 335 LEU A CG  1 
ATOM   1970 C CD1 . LEU A 1 335 ? 98.259  98.449  97.607  1.00 69.93  ? 335 LEU A CD1 1 
ATOM   1971 C CD2 . LEU A 1 335 ? 96.180  98.254  96.292  1.00 69.93  ? 335 LEU A CD2 1 
ATOM   1972 N N   . VAL A 1 336 ? 94.047  101.101 100.328 1.00 66.54  ? 336 VAL A N   1 
ATOM   1973 C CA  . VAL A 1 336 ? 93.141  101.144 101.474 1.00 66.54  ? 336 VAL A CA  1 
ATOM   1974 C C   . VAL A 1 336 ? 91.742  101.572 101.042 1.00 66.54  ? 336 VAL A C   1 
ATOM   1975 O O   . VAL A 1 336 ? 90.739  101.033 101.528 1.00 66.54  ? 336 VAL A O   1 
ATOM   1976 C CB  . VAL A 1 336 ? 93.721  102.063 102.564 1.00 66.54  ? 336 VAL A CB  1 
ATOM   1977 C CG1 . VAL A 1 336 ? 92.758  102.238 103.718 1.00 66.54  ? 336 VAL A CG1 1 
ATOM   1978 C CG2 . VAL A 1 336 ? 94.985  101.470 103.081 1.00 66.54  ? 336 VAL A CG2 1 
ATOM   1979 N N   . GLU A 1 337 ? 91.649  102.522 100.105 1.00 69.52  ? 337 GLU A N   1 
ATOM   1980 C CA  . GLU A 1 337 ? 90.333  102.903 99.587  1.00 69.52  ? 337 GLU A CA  1 
ATOM   1981 C C   . GLU A 1 337 ? 89.685  101.773 98.798  1.00 69.52  ? 337 GLU A C   1 
ATOM   1982 O O   . GLU A 1 337 ? 88.540  101.396 99.070  1.00 69.52  ? 337 GLU A O   1 
ATOM   1983 C CB  . GLU A 1 337 ? 90.410  104.154 98.719  1.00 69.52  ? 337 GLU A CB  1 
ATOM   1984 C CG  . GLU A 1 337 ? 90.469  105.432 99.494  1.00 69.52  ? 337 GLU A CG  1 
ATOM   1985 C CD  . GLU A 1 337 ? 90.332  106.647 98.604  1.00 69.52  ? 337 GLU A CD  1 
ATOM   1986 O OE1 . GLU A 1 337 ? 90.345  106.485 97.368  1.00 69.52  ? 337 GLU A OE1 1 
ATOM   1987 O OE2 . GLU A 1 337 ? 90.189  107.763 99.143  1.00 69.52  ? 337 GLU A OE2 1 
ATOM   1988 N N   . GLU A 1 338 ? 90.393  101.213 97.818  1.00 75.63  ? 338 GLU A N   1 
ATOM   1989 C CA  . GLU A 1 338 ? 89.787  100.163 97.011  1.00 75.63  ? 338 GLU A CA  1 
ATOM   1990 C C   . GLU A 1 338 ? 89.771  98.792  97.682  1.00 75.63  ? 338 GLU A C   1 
ATOM   1991 O O   . GLU A 1 338 ? 89.333  97.829  97.046  1.00 75.63  ? 338 GLU A O   1 
ATOM   1992 C CB  . GLU A 1 338 ? 90.446  100.079 95.628  1.00 75.63  ? 338 GLU A CB  1 
ATOM   1993 C CG  . GLU A 1 338 ? 89.783  100.994 94.580  1.00 75.63  ? 338 GLU A CG  1 
ATOM   1994 C CD  . GLU A 1 338 ? 90.403  102.364 94.404  1.00 75.63  ? 338 GLU A CD  1 
ATOM   1995 O OE1 . GLU A 1 338 ? 91.497  102.612 94.929  1.00 75.63  ? 338 GLU A OE1 1 
ATOM   1996 O OE2 . GLU A 1 338 ? 89.777  103.210 93.729  1.00 75.63  ? 338 GLU A OE2 1 
ATOM   1997 N N   . GLY A 1 339 ? 90.210  98.663  98.933  1.00 70.46  ? 339 GLY A N   1 
ATOM   1998 C CA  . GLY A 1 339 ? 89.694  97.550  99.706  1.00 70.46  ? 339 GLY A CA  1 
ATOM   1999 C C   . GLY A 1 339 ? 90.580  96.751  100.639 1.00 70.46  ? 339 GLY A C   1 
ATOM   2000 O O   . GLY A 1 339 ? 90.077  96.254  101.651 1.00 70.46  ? 339 GLY A O   1 
ATOM   2001 N N   . VAL A 1 340 ? 91.861  96.588  100.332 1.00 73.17  ? 340 VAL A N   1 
ATOM   2002 C CA  . VAL A 1 340 ? 92.709  95.760  101.201 1.00 73.17  ? 340 VAL A CA  1 
ATOM   2003 C C   . VAL A 1 340 ? 93.002  96.526  102.490 1.00 73.17  ? 340 VAL A C   1 
ATOM   2004 O O   . VAL A 1 340 ? 93.200  97.753  102.449 1.00 73.17  ? 340 VAL A O   1 
ATOM   2005 C CB  . VAL A 1 340 ? 93.994  95.330  100.460 1.00 73.17  ? 340 VAL A CB  1 
ATOM   2006 C CG1 . VAL A 1 340 ? 94.798  96.491  99.992  1.00 73.17  ? 340 VAL A CG1 1 
ATOM   2007 C CG2 . VAL A 1 340 ? 94.869  94.430  101.314 1.00 73.17  ? 340 VAL A CG2 1 
ATOM   2008 N N   . PRO A 1 341 ? 92.913  95.886  103.655 1.00 73.52  ? 341 PRO A N   1 
ATOM   2009 C CA  . PRO A 1 341 ? 93.034  96.631  104.909 1.00 73.52  ? 341 PRO A CA  1 
ATOM   2010 C C   . PRO A 1 341 ? 94.448  97.121  105.188 1.00 73.52  ? 341 PRO A C   1 
ATOM   2011 O O   . PRO A 1 341 ? 95.447  96.535  104.749 1.00 73.52  ? 341 PRO A O   1 
ATOM   2012 C CB  . PRO A 1 341 ? 92.580  95.616  105.961 1.00 73.52  ? 341 PRO A CB  1 
ATOM   2013 C CG  . PRO A 1 341 ? 91.688  94.698  105.231 1.00 73.52  ? 341 PRO A CG  1 
ATOM   2014 C CD  . PRO A 1 341 ? 92.289  94.569  103.871 1.00 73.52  ? 341 PRO A CD  1 
ATOM   2015 N N   . LYS A 1 342 ? 94.510  98.214  105.957 1.00 71.33  ? 342 LYS A N   1 
ATOM   2016 C CA  . LYS A 1 342 ? 95.783  98.827  106.321 1.00 71.33  ? 342 LYS A CA  1 
ATOM   2017 C C   . LYS A 1 342 ? 96.614  97.917  107.212 1.00 71.33  ? 342 LYS A C   1 
ATOM   2018 O O   . LYS A 1 342 ? 97.846  98.000  107.209 1.00 71.33  ? 342 LYS A O   1 
ATOM   2019 C CB  . LYS A 1 342 ? 95.531  100.165 107.016 1.00 71.33  ? 342 LYS A CB  1 
ATOM   2020 C CG  . LYS A 1 342 ? 94.752  100.064 108.318 1.00 71.33  ? 342 LYS A CG  1 
ATOM   2021 C CD  . LYS A 1 342 ? 94.530  101.419 108.949 1.00 71.33  ? 342 LYS A CD  1 
ATOM   2022 C CE  . LYS A 1 342 ? 93.791  101.285 110.266 1.00 71.33  ? 342 LYS A CE  1 
ATOM   2023 N NZ  . LYS A 1 342 ? 92.404  100.791 110.060 1.00 71.33  ? 342 LYS A NZ  1 
ATOM   2024 N N   . GLU A 1 343 ? 95.962  97.016  107.943 1.00 77.25  ? 343 GLU A N   1 
ATOM   2025 C CA  . GLU A 1 343 ? 96.671  96.112  108.832 1.00 77.25  ? 343 GLU A CA  1 
ATOM   2026 C C   . GLU A 1 343 ? 97.435  95.069  108.035 1.00 77.25  ? 343 GLU A C   1 
ATOM   2027 O O   . GLU A 1 343 ? 98.593  94.763  108.343 1.00 77.25  ? 343 GLU A O   1 
ATOM   2028 C CB  . GLU A 1 343 ? 95.673  95.458  109.786 1.00 77.25  ? 343 GLU A CB  1 
ATOM   2029 C CG  . GLU A 1 343 ? 94.925  96.477  110.639 1.00 77.25  ? 343 GLU A CG  1 
ATOM   2030 C CD  . GLU A 1 343 ? 93.639  96.981  110.015 1.00 77.25  ? 343 GLU A CD  1 
ATOM   2031 O OE1 . GLU A 1 343 ? 93.181  96.368  109.038 1.00 77.25  ? 343 GLU A OE1 1 
ATOM   2032 O OE2 . GLU A 1 343 ? 93.111  98.015  110.474 1.00 77.25  ? 343 GLU A OE2 1 
ATOM   2033 N N   . HIS A 1 344 ? 96.814  94.550  106.976 1.00 75.14  ? 344 HIS A N   1 
ATOM   2034 C CA  . HIS A 1 344 ? 97.509  93.633  106.085 1.00 75.14  ? 344 HIS A CA  1 
ATOM   2035 C C   . HIS A 1 344 ? 98.571  94.357  105.268 1.00 75.14  ? 344 HIS A C   1 
ATOM   2036 O O   . HIS A 1 344 ? 99.636  93.793  104.997 1.00 75.14  ? 344 HIS A O   1 
ATOM   2037 C CB  . HIS A 1 344 ? 96.507  92.934  105.174 1.00 75.14  ? 344 HIS A CB  1 
ATOM   2038 C CG  . HIS A 1 344 ? 95.553  92.046  105.906 1.00 75.14  ? 344 HIS A CG  1 
ATOM   2039 N ND1 . HIS A 1 344 ? 94.357  92.501  106.416 1.00 75.14  ? 344 HIS A ND1 1 
ATOM   2040 C CD2 . HIS A 1 344 ? 95.621  90.732  106.220 1.00 75.14  ? 344 HIS A CD2 1 
ATOM   2041 C CE1 . HIS A 1 344 ? 93.727  91.504  107.010 1.00 75.14  ? 344 HIS A CE1 1 
ATOM   2042 N NE2 . HIS A 1 344 ? 94.473  90.419  106.905 1.00 75.14  ? 344 HIS A NE2 1 
ATOM   2043 N N   . LEU A 1 345 ? 98.319  95.617  104.895 1.00 73.98  ? 345 LEU A N   1 
ATOM   2044 C CA  . LEU A 1 345 ? 99.352  96.364  104.176 1.00 73.98  ? 345 LEU A CA  1 
ATOM   2045 C C   . LEU A 1 345 ? 100.539 96.713  105.069 1.00 73.98  ? 345 LEU A C   1 
ATOM   2046 O O   . LEU A 1 345 ? 101.648 96.919  104.567 1.00 73.98  ? 345 LEU A O   1 
ATOM   2047 C CB  . LEU A 1 345 ? 98.777  97.636  103.565 1.00 73.98  ? 345 LEU A CB  1 
ATOM   2048 C CG  . LEU A 1 345 ? 97.745  97.423  102.467 1.00 73.98  ? 345 LEU A CG  1 
ATOM   2049 C CD1 . LEU A 1 345 ? 97.279  98.760  101.953 1.00 73.98  ? 345 LEU A CD1 1 
ATOM   2050 C CD2 . LEU A 1 345 ? 98.308  96.576  101.353 1.00 73.98  ? 345 LEU A CD2 1 
ATOM   2051 N N   . ALA A 1 346 ? 100.331 96.793  106.383 1.00 70.77  ? 346 ALA A N   1 
ATOM   2052 C CA  . ALA A 1 346 ? 101.456 96.994  107.288 1.00 70.77  ? 346 ALA A CA  1 
ATOM   2053 C C   . ALA A 1 346 ? 102.205 95.692  107.535 1.00 70.77  ? 346 ALA A C   1 
ATOM   2054 O O   . ALA A 1 346 ? 103.439 95.664  107.490 1.00 70.77  ? 346 ALA A O   1 
ATOM   2055 C CB  . ALA A 1 346 ? 100.972 97.582  108.606 1.00 70.77  ? 346 ALA A CB  1 
ATOM   2056 N N   . LEU A 1 347 ? 101.474 94.597  107.771 1.00 74.40  ? 347 LEU A N   1 
ATOM   2057 C CA  . LEU A 1 347 ? 102.087 93.284  107.964 1.00 74.40  ? 347 LEU A CA  1 
ATOM   2058 C C   . LEU A 1 347 ? 102.710 92.725  106.697 1.00 74.40  ? 347 LEU A C   1 
ATOM   2059 O O   . LEU A 1 347 ? 103.409 91.711  106.757 1.00 74.40  ? 347 LEU A O   1 
ATOM   2060 C CB  . LEU A 1 347 ? 101.048 92.309  108.484 1.00 74.40  ? 347 LEU A CB  1 
ATOM   2061 C CG  . LEU A 1 347 ? 100.695 92.604  109.923 1.00 74.40  ? 347 LEU A CG  1 
ATOM   2062 C CD1 . LEU A 1 347 ? 99.409  91.923  110.239 1.00 74.40  ? 347 LEU A CD1 1 
ATOM   2063 C CD2 . LEU A 1 347 ? 101.816 92.058  110.778 1.00 74.40  ? 347 LEU A CD2 1 
ATOM   2064 N N   . LEU A 1 348 ? 102.451 93.349  105.553 1.00 75.24  ? 348 LEU A N   1 
ATOM   2065 C CA  . LEU A 1 348 ? 103.124 93.037  104.306 1.00 75.24  ? 348 LEU A CA  1 
ATOM   2066 C C   . LEU A 1 348 ? 104.606 93.408  104.312 1.00 75.24  ? 348 LEU A C   1 
ATOM   2067 O O   . LEU A 1 348 ? 105.334 92.977  103.412 1.00 75.24  ? 348 LEU A O   1 
ATOM   2068 C CB  . LEU A 1 348 ? 102.358 93.763  103.209 1.00 75.24  ? 348 LEU A CB  1 
ATOM   2069 C CG  . LEU A 1 348 ? 102.541 93.580  101.721 1.00 75.24  ? 348 LEU A CG  1 
ATOM   2070 C CD1 . LEU A 1 348 ? 101.193 93.808  101.130 1.00 75.24  ? 348 LEU A CD1 1 
ATOM   2071 C CD2 . LEU A 1 348 ? 103.465 94.638  101.241 1.00 75.24  ? 348 LEU A CD2 1 
ATOM   2072 N N   . ALA A 1 349 ? 105.075 94.180  105.296 1.00 81.08  ? 349 ALA A N   1 
ATOM   2073 C CA  . ALA A 1 349 ? 106.473 94.588  105.339 1.00 81.08  ? 349 ALA A CA  1 
ATOM   2074 C C   . ALA A 1 349 ? 107.350 93.662  106.173 1.00 81.08  ? 349 ALA A C   1 
ATOM   2075 O O   . ALA A 1 349 ? 108.578 93.775  106.098 1.00 81.08  ? 349 ALA A O   1 
ATOM   2076 C CB  . ALA A 1 349 ? 106.586 96.014  105.880 1.00 81.08  ? 349 ALA A CB  1 
ATOM   2077 N N   . VAL A 1 350 ? 106.768 92.772  106.971 1.00 82.69  ? 350 VAL A N   1 
ATOM   2078 C CA  . VAL A 1 350 ? 107.561 91.832  107.768 1.00 82.69  ? 350 VAL A CA  1 
ATOM   2079 C C   . VAL A 1 350 ? 108.323 90.793  106.929 1.00 82.69  ? 350 VAL A C   1 
ATOM   2080 O O   . VAL A 1 350 ? 109.368 90.331  107.410 1.00 82.69  ? 350 VAL A O   1 
ATOM   2081 C CB  . VAL A 1 350 ? 106.702 91.190  108.888 1.00 82.69  ? 350 VAL A CB  1 
ATOM   2082 C CG1 . VAL A 1 350 ? 105.740 90.121  108.414 1.00 82.69  ? 350 VAL A CG1 1 
ATOM   2083 C CG2 . VAL A 1 350 ? 107.563 90.663  110.045 1.00 82.69  ? 350 VAL A CG2 1 
ATOM   2084 N N   . PRO A 1 351 ? 107.952 90.397  105.688 1.00 85.97  ? 351 PRO A N   1 
ATOM   2085 C CA  . PRO A 1 351 ? 108.927 89.608  104.916 1.00 85.97  ? 351 PRO A CA  1 
ATOM   2086 C C   . PRO A 1 351 ? 110.031 90.437  104.293 1.00 85.97  ? 351 PRO A C   1 
ATOM   2087 O O   . PRO A 1 351 ? 110.908 89.862  103.638 1.00 85.97  ? 351 PRO A O   1 
ATOM   2088 C CB  . PRO A 1 351 ? 108.074 88.934  103.832 1.00 85.97  ? 351 PRO A CB  1 
ATOM   2089 C CG  . PRO A 1 351 ? 106.717 88.995  104.317 1.00 85.97  ? 351 PRO A CG  1 
ATOM   2090 C CD  . PRO A 1 351 ? 106.650 90.312  104.990 1.00 85.97  ? 351 PRO A CD  1 
ATOM   2091 N N   . MET A 1 352 ? 110.024 91.761  104.457 1.00 91.74  ? 352 MET A N   1 
ATOM   2092 C CA  . MET A 1 352 ? 111.007 92.573  103.752 1.00 91.74  ? 352 MET A CA  1 
ATOM   2093 C C   . MET A 1 352 ? 112.229 92.887  104.604 1.00 91.74  ? 352 MET A C   1 
ATOM   2094 O O   . MET A 1 352 ? 113.309 93.122  104.053 1.00 91.74  ? 352 MET A O   1 
ATOM   2095 C CB  . MET A 1 352 ? 110.367 93.863  103.249 1.00 91.74  ? 352 MET A CB  1 
ATOM   2096 C CG  . MET A 1 352 ? 109.335 93.634  102.173 1.00 91.74  ? 352 MET A CG  1 
ATOM   2097 S SD  . MET A 1 352 ? 110.037 92.644  100.849 1.00 91.74  ? 352 MET A SD  1 
ATOM   2098 C CE  . MET A 1 352 ? 111.321 93.739  100.266 1.00 91.74  ? 352 MET A CE  1 
ATOM   2099 N N   . VAL A 1 353 ? 112.091 92.906  105.927 1.00 94.41  ? 353 VAL A N   1 
ATOM   2100 C CA  . VAL A 1 353 ? 113.229 93.194  106.803 1.00 94.41  ? 353 VAL A CA  1 
ATOM   2101 C C   . VAL A 1 353 ? 114.313 92.100  106.780 1.00 94.41  ? 353 VAL A C   1 
ATOM   2102 O O   . VAL A 1 353 ? 115.496 92.471  106.889 1.00 94.41  ? 353 VAL A O   1 
ATOM   2103 C CB  . VAL A 1 353 ? 112.734 93.583  108.223 1.00 94.41  ? 353 VAL A CB  1 
ATOM   2104 C CG1 . VAL A 1 353 ? 111.919 92.515  108.933 1.00 94.41  ? 353 VAL A CG1 1 
ATOM   2105 C CG2 . VAL A 1 353 ? 113.868 94.085  109.123 1.00 94.41  ? 353 VAL A CG2 1 
ATOM   2106 N N   . PRO A 1 354 ? 114.053 90.791  106.546 1.00 99.58  ? 354 PRO A N   1 
ATOM   2107 C CA  . PRO A 1 354 ? 115.209 89.933  106.222 1.00 99.58  ? 354 PRO A CA  1 
ATOM   2108 C C   . PRO A 1 354 ? 115.813 90.253  104.870 1.00 99.58  ? 354 PRO A C   1 
ATOM   2109 O O   . PRO A 1 354 ? 117.040 90.220  104.722 1.00 99.58  ? 354 PRO A O   1 
ATOM   2110 C CB  . PRO A 1 354 ? 114.632 88.511  106.259 1.00 99.58  ? 354 PRO A CB  1 
ATOM   2111 C CG  . PRO A 1 354 ? 113.439 88.605  107.067 1.00 99.58  ? 354 PRO A CG  1 
ATOM   2112 C CD  . PRO A 1 354 ? 112.863 89.924  106.714 1.00 99.58  ? 354 PRO A CD  1 
ATOM   2113 N N   . LEU A 1 355 ? 114.988 90.599  103.882 1.00 102.92 ? 355 LEU A N   1 
ATOM   2114 C CA  . LEU A 1 355 ? 115.544 91.029  102.606 1.00 102.92 ? 355 LEU A CA  1 
ATOM   2115 C C   . LEU A 1 355 ? 116.192 92.406  102.727 1.00 102.92 ? 355 LEU A C   1 
ATOM   2116 O O   . LEU A 1 355 ? 117.147 92.702  102.002 1.00 102.92 ? 355 LEU A O   1 
ATOM   2117 C CB  . LEU A 1 355 ? 114.458 91.006  101.528 1.00 102.92 ? 355 LEU A CB  1 
ATOM   2118 C CG  . LEU A 1 355 ? 114.912 91.205  100.080 1.00 102.92 ? 355 LEU A CG  1 
ATOM   2119 C CD1 . LEU A 1 355 ? 115.917 90.135  99.694  1.00 102.92 ? 355 LEU A CD1 1 
ATOM   2120 C CD2 . LEU A 1 355 ? 113.738 91.166  99.127  1.00 102.92 ? 355 LEU A CD2 1 
ATOM   2121 N N   . GLN A 1 356 ? 115.729 93.237  103.668 1.00 95.02  ? 356 GLN A N   1 
ATOM   2122 C CA  . GLN A 1 356 ? 116.428 94.484  103.968 1.00 95.02  ? 356 GLN A CA  1 
ATOM   2123 C C   . GLN A 1 356 ? 117.790 94.221  104.606 1.00 95.02  ? 356 GLN A C   1 
ATOM   2124 O O   . GLN A 1 356 ? 118.713 95.025  104.447 1.00 95.02  ? 356 GLN A O   1 
ATOM   2125 C CB  . GLN A 1 356 ? 115.560 95.367  104.870 1.00 95.02  ? 356 GLN A CB  1 
ATOM   2126 C CG  . GLN A 1 356 ? 116.100 96.764  105.147 1.00 95.02  ? 356 GLN A CG  1 
ATOM   2127 C CD  . GLN A 1 356 ? 115.136 97.609  105.951 1.00 95.02  ? 356 GLN A CD  1 
ATOM   2128 O OE1 . GLN A 1 356 ? 114.049 97.159  106.308 1.00 95.02  ? 356 GLN A OE1 1 
ATOM   2129 N NE2 . GLN A 1 356 ? 115.533 98.842  106.244 1.00 95.02  ? 356 GLN A NE2 1 
ATOM   2130 N N   . ILE A 1 357 ? 117.942 93.102  105.318 1.00 105.22 ? 357 ILE A N   1 
ATOM   2131 C CA  . ILE A 1 357 ? 119.278 92.696  105.754 1.00 105.22 ? 357 ILE A CA  1 
ATOM   2132 C C   . ILE A 1 357 ? 120.113 92.220  104.566 1.00 105.22 ? 357 ILE A C   1 
ATOM   2133 O O   . ILE A 1 357 ? 121.278 92.610  104.414 1.00 105.22 ? 357 ILE A O   1 
ATOM   2134 C CB  . ILE A 1 357 ? 119.180 91.617  106.852 1.00 105.22 ? 357 ILE A CB  1 
ATOM   2135 C CG1 . ILE A 1 357 ? 118.552 92.192  108.123 1.00 105.22 ? 357 ILE A CG1 1 
ATOM   2136 C CG2 . ILE A 1 357 ? 120.544 91.017  107.167 1.00 105.22 ? 357 ILE A CG2 1 
ATOM   2137 C CD1 . ILE A 1 357 ? 118.209 91.141  109.162 1.00 105.22 ? 357 ILE A CD1 1 
ATOM   2138 N N   . ILE A 1 358 ? 119.521 91.403  103.689 1.00 107.36 ? 358 ILE A N   1 
ATOM   2139 C CA  . ILE A 1 358 ? 120.295 90.684  102.672 1.00 107.36 ? 358 ILE A CA  1 
ATOM   2140 C C   . ILE A 1 358 ? 120.747 91.611  101.538 1.00 107.36 ? 358 ILE A C   1 
ATOM   2141 O O   . ILE A 1 358 ? 121.877 91.489  101.044 1.00 107.36 ? 358 ILE A O   1 
ATOM   2142 C CB  . ILE A 1 358 ? 119.482 89.476  102.157 1.00 107.36 ? 358 ILE A CB  1 
ATOM   2143 C CG1 . ILE A 1 358 ? 119.300 88.442  103.270 1.00 107.36 ? 358 ILE A CG1 1 
ATOM   2144 C CG2 . ILE A 1 358 ? 120.138 88.792  100.969 1.00 107.36 ? 358 ILE A CG2 1 
ATOM   2145 C CD1 . ILE A 1 358 ? 120.599 87.866  103.792 1.00 107.36 ? 358 ILE A CD1 1 
ATOM   2146 N N   . LEU A 1 359 ? 119.908 92.573  101.139 1.00 105.97 ? 359 LEU A N   1 
ATOM   2147 C CA  . LEU A 1 359 ? 120.175 93.338  99.916  1.00 105.97 ? 359 LEU A CA  1 
ATOM   2148 C C   . LEU A 1 359 ? 121.404 94.256  99.933  1.00 105.97 ? 359 LEU A C   1 
ATOM   2149 O O   . LEU A 1 359 ? 122.067 94.335  98.884  1.00 105.97 ? 359 LEU A O   1 
ATOM   2150 C CB  . LEU A 1 359 ? 118.928 94.140  99.515  1.00 105.97 ? 359 LEU A CB  1 
ATOM   2151 C CG  . LEU A 1 359 ? 117.762 93.389  98.880  1.00 105.97 ? 359 LEU A CG  1 
ATOM   2152 C CD1 . LEU A 1 359 ? 116.569 94.317  98.792  1.00 105.97 ? 359 LEU A CD1 1 
ATOM   2153 C CD2 . LEU A 1 359 ? 118.144 92.862  97.507  1.00 105.97 ? 359 LEU A CD2 1 
ATOM   2154 N N   . PRO A 1 360 ? 121.764 94.978  101.012 1.00 110.39 ? 360 PRO A N   1 
ATOM   2155 C CA  . PRO A 1 360 ? 123.069 95.665  100.982 1.00 110.39 ? 360 PRO A CA  1 
ATOM   2156 C C   . PRO A 1 360 ? 124.255 94.720  100.917 1.00 110.39 ? 360 PRO A C   1 
ATOM   2157 O O   . PRO A 1 360 ? 125.272 95.070  100.309 1.00 110.39 ? 360 PRO A O   1 
ATOM   2158 C CB  . PRO A 1 360 ? 123.068 96.489  102.277 1.00 110.39 ? 360 PRO A CB  1 
ATOM   2159 C CG  . PRO A 1 360 ? 121.653 96.730  102.552 1.00 110.39 ? 360 PRO A CG  1 
ATOM   2160 C CD  . PRO A 1 360 ? 120.960 95.469  102.149 1.00 110.39 ? 360 PRO A CD  1 
ATOM   2161 N N   . LEU A 1 361 ? 124.133 93.505  101.458 1.00 113.41 ? 361 LEU A N   1 
ATOM   2162 C CA  . LEU A 1 361 ? 125.188 92.509  101.301 1.00 113.41 ? 361 LEU A CA  1 
ATOM   2163 C C   . LEU A 1 361 ? 125.288 91.983  99.872  1.00 113.41 ? 361 LEU A C   1 
ATOM   2164 O O   . LEU A 1 361 ? 126.308 91.384  99.518  1.00 113.41 ? 361 LEU A O   1 
ATOM   2165 C CB  . LEU A 1 361 ? 124.964 91.347  102.270 1.00 113.41 ? 361 LEU A CB  1 
ATOM   2166 C CG  . LEU A 1 361 ? 125.083 91.675  103.760 1.00 113.41 ? 361 LEU A CG  1 
ATOM   2167 C CD1 . LEU A 1 361 ? 124.696 90.474  104.608 1.00 113.41 ? 361 LEU A CD1 1 
ATOM   2168 C CD2 . LEU A 1 361 ? 126.490 92.139  104.096 1.00 113.41 ? 361 LEU A CD2 1 
ATOM   2169 N N   . ILE A 1 362 ? 124.259 92.184  99.051  1.00 114.12 ? 362 ILE A N   1 
ATOM   2170 C CA  . ILE A 1 362 ? 124.340 91.859  97.629  1.00 114.12 ? 362 ILE A CA  1 
ATOM   2171 C C   . ILE A 1 362 ? 124.870 93.038  96.821  1.00 114.12 ? 362 ILE A C   1 
ATOM   2172 O O   . ILE A 1 362 ? 125.739 92.869  95.961  1.00 114.12 ? 362 ILE A O   1 
ATOM   2173 C CB  . ILE A 1 362 ? 122.960 91.395  97.116  1.00 114.12 ? 362 ILE A CB  1 
ATOM   2174 C CG1 . ILE A 1 362 ? 122.539 90.100  97.807  1.00 114.12 ? 362 ILE A CG1 1 
ATOM   2175 C CG2 . ILE A 1 362 ? 122.966 91.192  95.607  1.00 114.12 ? 362 ILE A CG2 1 
ATOM   2176 C CD1 . ILE A 1 362 ? 121.121 89.685  97.486  1.00 114.12 ? 362 ILE A CD1 1 
ATOM   2177 N N   . ILE A 1 363 ? 124.404 94.255  97.113  1.00 111.95 ? 363 ILE A N   1 
ATOM   2178 C CA  . ILE A 1 363 ? 124.727 95.421  96.291  1.00 111.95 ? 363 ILE A CA  1 
ATOM   2179 C C   . ILE A 1 363 ? 125.956 96.112  96.899  1.00 111.95 ? 363 ILE A C   1 
ATOM   2180 O O   . ILE A 1 363 ? 126.286 97.256  96.565  1.00 111.95 ? 363 ILE A O   1 
ATOM   2181 C CB  . ILE A 1 363 ? 123.496 96.352  96.170  1.00 111.95 ? 363 ILE A CB  1 
ATOM   2182 C CG1 . ILE A 1 363 ? 122.229 95.537  95.897  1.00 111.95 ? 363 ILE A CG1 1 
ATOM   2183 C CG2 . ILE A 1 363 ? 123.581 97.294  94.958  1.00 111.95 ? 363 ILE A CG2 1 
ATOM   2184 C CD1 . ILE A 1 363 ? 122.223 94.743  94.594  1.00 111.95 ? 363 ILE A CD1 1 
ATOM   2185 N N   . SER A 1 364 ? 126.659 95.409  97.798  1.00 116.40 ? 364 SER A N   1 
ATOM   2186 C CA  . SER A 1 364 ? 127.946 95.894  98.291  1.00 116.40 ? 364 SER A CA  1 
ATOM   2187 C C   . SER A 1 364 ? 128.991 95.994  97.186  1.00 116.40 ? 364 SER A C   1 
ATOM   2188 O O   . SER A 1 364 ? 129.887 96.842  97.263  1.00 116.40 ? 364 SER A O   1 
ATOM   2189 C CB  . SER A 1 364 ? 128.457 94.983  99.405  1.00 116.40 ? 364 SER A CB  1 
ATOM   2190 O OG  . SER A 1 364 ? 128.769 93.696  98.903  1.00 116.40 ? 364 SER A OG  1 
ATOM   2191 N N   . LYS A 1 365 ? 128.892 95.151  96.154  1.00 117.23 ? 365 LYS A N   1 
ATOM   2192 C CA  . LYS A 1 365 ? 129.812 95.246  95.024  1.00 117.23 ? 365 LYS A CA  1 
ATOM   2193 C C   . LYS A 1 365 ? 129.590 96.533  94.237  1.00 117.23 ? 365 LYS A C   1 
ATOM   2194 O O   . LYS A 1 365 ? 130.551 97.238  93.904  1.00 117.23 ? 365 LYS A O   1 
ATOM   2195 C CB  . LYS A 1 365 ? 129.656 94.021  94.123  1.00 117.23 ? 365 LYS A CB  1 
ATOM   2196 C CG  . LYS A 1 365 ? 130.604 93.984  92.939  1.00 117.23 ? 365 LYS A CG  1 
ATOM   2197 C CD  . LYS A 1 365 ? 130.494 92.660  92.203  1.00 117.23 ? 365 LYS A CD  1 
ATOM   2198 C CE  . LYS A 1 365 ? 129.184 92.563  91.438  1.00 117.23 ? 365 LYS A CE  1 
ATOM   2199 N NZ  . LYS A 1 365 ? 129.101 91.317  90.627  1.00 117.23 ? 365 LYS A NZ  1 
ATOM   2200 N N   . TYR A 1 366 ? 128.327 96.875  93.965  1.00 112.28 ? 366 TYR A N   1 
ATOM   2201 C CA  . TYR A 1 366 ? 128.012 98.135  93.301  1.00 112.28 ? 366 TYR A CA  1 
ATOM   2202 C C   . TYR A 1 366 ? 128.254 99.338  94.204  1.00 112.28 ? 366 TYR A C   1 
ATOM   2203 O O   . TYR A 1 366 ? 128.470 100.445 93.699  1.00 112.28 ? 366 TYR A O   1 
ATOM   2204 C CB  . TYR A 1 366 ? 126.559 98.128  92.825  1.00 112.28 ? 366 TYR A CB  1 
ATOM   2205 C CG  . TYR A 1 366 ? 126.265 97.168  91.688  1.00 112.28 ? 366 TYR A CG  1 
ATOM   2206 C CD1 . TYR A 1 366 ? 127.287 96.653  90.896  1.00 112.28 ? 366 TYR A CD1 1 
ATOM   2207 C CD2 . TYR A 1 366 ? 124.960 96.770  91.415  1.00 112.28 ? 366 TYR A CD2 1 
ATOM   2208 C CE1 . TYR A 1 366 ? 127.015 95.775  89.861  1.00 112.28 ? 366 TYR A CE1 1 
ATOM   2209 C CE2 . TYR A 1 366 ? 124.679 95.893  90.382  1.00 112.28 ? 366 TYR A CE2 1 
ATOM   2210 C CZ  . TYR A 1 366 ? 125.710 95.399  89.611  1.00 112.28 ? 366 TYR A CZ  1 
ATOM   2211 O OH  . TYR A 1 366 ? 125.434 94.526  88.584  1.00 112.28 ? 366 TYR A OH  1 
ATOM   2212 N N   . THR A 1 367 ? 128.207 99.144  95.523  1.00 112.80 ? 367 THR A N   1 
ATOM   2213 C CA  . THR A 1 367 ? 128.601 100.192 96.460  1.00 112.80 ? 367 THR A CA  1 
ATOM   2214 C C   . THR A 1 367 ? 130.098 100.472 96.379  1.00 112.80 ? 367 THR A C   1 
ATOM   2215 O O   . THR A 1 367 ? 130.519 101.624 96.221  1.00 112.80 ? 367 THR A O   1 
ATOM   2216 C CB  . THR A 1 367 ? 128.205 99.785  97.881  1.00 112.80 ? 367 THR A CB  1 
ATOM   2217 O OG1 . THR A 1 367 ? 126.778 99.705  97.980  1.00 112.80 ? 367 THR A OG1 1 
ATOM   2218 C CG2 . THR A 1 367 ? 128.748 100.766 98.916  1.00 112.80 ? 367 THR A CG2 1 
ATOM   2219 N N   . ALA A 1 368 ? 130.917 99.425  96.479  1.00 111.74 ? 368 ALA A N   1 
ATOM   2220 C CA  . ALA A 1 368 ? 132.365 99.579  96.489  1.00 111.74 ? 368 ALA A CA  1 
ATOM   2221 C C   . ALA A 1 368 ? 132.955 99.852  95.111  1.00 111.74 ? 368 ALA A C   1 
ATOM   2222 O O   . ALA A 1 368 ? 134.131 100.226 95.031  1.00 111.74 ? 368 ALA A O   1 
ATOM   2223 C CB  . ALA A 1 368 ? 133.020 98.331  97.086  1.00 111.74 ? 368 ALA A CB  1 
ATOM   2224 N N   . GLY A 1 369 ? 132.186 99.665  94.036  1.00 104.73 ? 369 GLY A N   1 
ATOM   2225 C CA  . GLY A 1 369 ? 132.654 99.959  92.701  1.00 104.73 ? 369 GLY A CA  1 
ATOM   2226 C C   . GLY A 1 369 ? 132.935 101.431 92.466  1.00 104.73 ? 369 GLY A C   1 
ATOM   2227 O O   . GLY A 1 369 ? 132.461 102.304 93.199  1.00 104.73 ? 369 GLY A O   1 
ATOM   2228 N N   . PRO A 1 370 ? 133.723 101.734 91.429  1.00 103.10 ? 370 PRO A N   1 
ATOM   2229 C CA  . PRO A 1 370 ? 134.110 103.132 91.179  1.00 103.10 ? 370 PRO A CA  1 
ATOM   2230 C C   . PRO A 1 370 ? 133.003 103.987 90.587  1.00 103.10 ? 370 PRO A C   1 
ATOM   2231 O O   . PRO A 1 370 ? 133.163 105.213 90.535  1.00 103.10 ? 370 PRO A O   1 
ATOM   2232 C CB  . PRO A 1 370 ? 135.282 102.999 90.203  1.00 103.10 ? 370 PRO A CB  1 
ATOM   2233 C CG  . PRO A 1 370 ? 135.017 101.722 89.487  1.00 103.10 ? 370 PRO A CG  1 
ATOM   2234 C CD  . PRO A 1 370 ? 134.373 100.804 90.489  1.00 103.10 ? 370 PRO A CD  1 
ATOM   2235 N N   . GLN A 1 371 ? 131.899 103.394 90.134  1.00 93.04  ? 371 GLN A N   1 
ATOM   2236 C CA  . GLN A 1 371 ? 130.755 104.133 89.602  1.00 93.04  ? 371 GLN A CA  1 
ATOM   2237 C C   . GLN A 1 371 ? 129.536 103.791 90.446  1.00 93.04  ? 371 GLN A C   1 
ATOM   2238 O O   . GLN A 1 371 ? 128.771 102.875 90.108  1.00 93.04  ? 371 GLN A O   1 
ATOM   2239 C CB  . GLN A 1 371 ? 130.522 103.805 88.130  1.00 93.04  ? 371 GLN A CB  1 
ATOM   2240 C CG  . GLN A 1 371 ? 131.622 104.300 87.211  1.00 93.04  ? 371 GLN A CG  1 
ATOM   2241 C CD  . GLN A 1 371 ? 131.345 103.986 85.757  1.00 93.04  ? 371 GLN A CD  1 
ATOM   2242 O OE1 . GLN A 1 371 ? 130.350 103.343 85.427  1.00 93.04  ? 371 GLN A OE1 1 
ATOM   2243 N NE2 . GLN A 1 371 ? 132.227 104.441 84.875  1.00 93.04  ? 371 GLN A NE2 1 
ATOM   2244 N N   . PRO A 1 372 ? 129.314 104.500 91.556  1.00 88.77  ? 372 PRO A N   1 
ATOM   2245 C CA  . PRO A 1 372 ? 128.214 104.138 92.460  1.00 88.77  ? 372 PRO A CA  1 
ATOM   2246 C C   . PRO A 1 372 ? 126.831 104.522 91.968  1.00 88.77  ? 372 PRO A C   1 
ATOM   2247 O O   . PRO A 1 372 ? 125.844 104.024 92.525  1.00 88.77  ? 372 PRO A O   1 
ATOM   2248 C CB  . PRO A 1 372 ? 128.562 104.900 93.741  1.00 88.77  ? 372 PRO A CB  1 
ATOM   2249 C CG  . PRO A 1 372 ? 129.353 106.054 93.281  1.00 88.77  ? 372 PRO A CG  1 
ATOM   2250 C CD  . PRO A 1 372 ? 130.148 105.578 92.108  1.00 88.77  ? 372 PRO A CD  1 
ATOM   2251 N N   . LEU A 1 373 ? 126.713 105.386 90.965  1.00 83.55  ? 373 LEU A N   1 
ATOM   2252 C CA  . LEU A 1 373 ? 125.412 105.738 90.412  1.00 83.55  ? 373 LEU A CA  1 
ATOM   2253 C C   . LEU A 1 373 ? 125.002 104.838 89.257  1.00 83.55  ? 373 LEU A C   1 
ATOM   2254 O O   . LEU A 1 373 ? 123.957 105.080 88.640  1.00 83.55  ? 373 LEU A O   1 
ATOM   2255 C CB  . LEU A 1 373 ? 125.409 107.193 89.951  1.00 83.55  ? 373 LEU A CB  1 
ATOM   2256 C CG  . LEU A 1 373 ? 125.565 108.216 91.070  1.00 83.55  ? 373 LEU A CG  1 
ATOM   2257 C CD1 . LEU A 1 373 ? 125.662 109.597 90.479  1.00 83.55  ? 373 LEU A CD1 1 
ATOM   2258 C CD2 . LEU A 1 373 ? 124.406 108.128 92.036  1.00 83.55  ? 373 LEU A CD2 1 
ATOM   2259 N N   . ASN A 1 374 ? 125.800 103.811 88.957  1.00 81.27  ? 374 ASN A N   1 
ATOM   2260 C CA  . ASN A 1 374 ? 125.462 102.884 87.886  1.00 81.27  ? 374 ASN A CA  1 
ATOM   2261 C C   . ASN A 1 374 ? 124.212 102.086 88.235  1.00 81.27  ? 374 ASN A C   1 
ATOM   2262 O O   . ASN A 1 374 ? 123.309 101.945 87.404  1.00 81.27  ? 374 ASN A O   1 
ATOM   2263 C CB  . ASN A 1 374 ? 126.646 101.956 87.615  1.00 81.27  ? 374 ASN A CB  1 
ATOM   2264 C CG  . ASN A 1 374 ? 126.529 101.215 86.297  1.00 81.27  ? 374 ASN A CG  1 
ATOM   2265 O OD1 . ASN A 1 374 ? 125.573 101.397 85.544  1.00 81.27  ? 374 ASN A OD1 1 
ATOM   2266 N ND2 . ASN A 1 374 ? 127.510 100.369 86.012  1.00 81.27  ? 374 ASN A ND2 1 
ATOM   2267 N N   . THR A 1 375 ? 124.120 101.593 89.471  1.00 81.38  ? 375 THR A N   1 
ATOM   2268 C CA  . THR A 1 375 ? 122.911 100.886 89.869  1.00 81.38  ? 375 THR A CA  1 
ATOM   2269 C C   . THR A 1 375 ? 121.738 101.829 90.117  1.00 81.38  ? 375 THR A C   1 
ATOM   2270 O O   . THR A 1 375 ? 120.592 101.396 89.978  1.00 81.38  ? 375 THR A O   1 
ATOM   2271 C CB  . THR A 1 375 ? 123.187 100.003 91.089  1.00 81.38  ? 375 THR A CB  1 
ATOM   2272 O OG1 . THR A 1 375 ? 121.980 99.346  91.494  1.00 81.38  ? 375 THR A OG1 1 
ATOM   2273 C CG2 . THR A 1 375 ? 123.759 100.798 92.227  1.00 81.38  ? 375 THR A CG2 1 
ATOM   2274 N N   . PHE A 1 376 ? 121.994 103.111 90.407  1.00 77.36  ? 376 PHE A N   1 
ATOM   2275 C CA  . PHE A 1 376 ? 120.931 104.119 90.386  1.00 77.36  ? 376 PHE A CA  1 
ATOM   2276 C C   . PHE A 1 376 ? 120.311 104.224 88.998  1.00 77.36  ? 376 PHE A C   1 
ATOM   2277 O O   . PHE A 1 376 ? 119.089 104.114 88.833  1.00 77.36  ? 376 PHE A O   1 
ATOM   2278 C CB  . PHE A 1 376 ? 121.494 105.482 90.799  1.00 77.36  ? 376 PHE A CB  1 
ATOM   2279 C CG  . PHE A 1 376 ? 120.460 106.575 90.930  1.00 77.36  ? 376 PHE A CG  1 
ATOM   2280 C CD1 . PHE A 1 376 ? 119.775 106.756 92.112  1.00 77.36  ? 376 PHE A CD1 1 
ATOM   2281 C CD2 . PHE A 1 376 ? 120.177 107.424 89.871  1.00 77.36  ? 376 PHE A CD2 1 
ATOM   2282 C CE1 . PHE A 1 376 ? 118.835 107.762 92.242  1.00 77.36  ? 376 PHE A CE1 1 
ATOM   2283 C CE2 . PHE A 1 376 ? 119.225 108.415 89.996  1.00 77.36  ? 376 PHE A CE2 1 
ATOM   2284 C CZ  . PHE A 1 376 ? 118.560 108.585 91.185  1.00 77.36  ? 376 PHE A CZ  1 
ATOM   2285 N N   . TYR A 1 377 ? 121.151 104.452 87.990  1.00 75.28  ? 377 TYR A N   1 
ATOM   2286 C CA  . TYR A 1 377 ? 120.671 104.654 86.630  1.00 75.28  ? 377 TYR A CA  1 
ATOM   2287 C C   . TYR A 1 377 ? 120.140 103.371 85.999  1.00 75.28  ? 377 TYR A C   1 
ATOM   2288 O O   . TYR A 1 377 ? 119.325 103.447 85.075  1.00 75.28  ? 377 TYR A O   1 
ATOM   2289 C CB  . TYR A 1 377 ? 121.799 105.259 85.796  1.00 75.28  ? 377 TYR A CB  1 
ATOM   2290 C CG  . TYR A 1 377 ? 121.453 105.556 84.363  1.00 75.28  ? 377 TYR A CG  1 
ATOM   2291 C CD1 . TYR A 1 377 ? 120.606 106.602 84.039  1.00 75.28  ? 377 TYR A CD1 1 
ATOM   2292 C CD2 . TYR A 1 377 ? 122.001 104.808 83.332  1.00 75.28  ? 377 TYR A CD2 1 
ATOM   2293 C CE1 . TYR A 1 377 ? 120.298 106.880 82.728  1.00 75.28  ? 377 TYR A CE1 1 
ATOM   2294 C CE2 . TYR A 1 377 ? 121.700 105.080 82.018  1.00 75.28  ? 377 TYR A CE2 1 
ATOM   2295 C CZ  . TYR A 1 377 ? 120.849 106.118 81.722  1.00 75.28  ? 377 TYR A CZ  1 
ATOM   2296 O OH  . TYR A 1 377 ? 120.546 106.392 80.410  1.00 75.28  ? 377 TYR A OH  1 
ATOM   2297 N N   . LYS A 1 378 ? 120.557 102.200 86.477  1.00 67.79  ? 378 LYS A N   1 
ATOM   2298 C CA  . LYS A 1 378 ? 119.996 100.949 85.983  1.00 67.79  ? 378 LYS A CA  1 
ATOM   2299 C C   . LYS A 1 378 ? 118.847 100.427 86.836  1.00 67.79  ? 378 LYS A C   1 
ATOM   2300 O O   . LYS A 1 378 ? 118.240 99.417  86.470  1.00 67.79  ? 378 LYS A O   1 
ATOM   2301 C CB  . LYS A 1 378 ? 121.082 99.875  85.879  1.00 67.79  ? 378 LYS A CB  1 
ATOM   2302 C CG  . LYS A 1 378 ? 122.172 100.188 84.870  1.00 67.79  ? 378 LYS A CG  1 
ATOM   2303 C CD  . LYS A 1 378 ? 121.640 100.188 83.450  1.00 67.79  ? 378 LYS A CD  1 
ATOM   2304 C CE  . LYS A 1 378 ? 122.760 100.431 82.452  1.00 67.79  ? 378 LYS A CE  1 
ATOM   2305 N NZ  . LYS A 1 378 ? 122.266 100.478 81.048  1.00 67.79  ? 378 LYS A NZ  1 
ATOM   2306 N N   . ALA A 1 379 ? 118.541 101.071 87.962  1.00 67.81  ? 379 ALA A N   1 
ATOM   2307 C CA  . ALA A 1 379 ? 117.354 100.745 88.734  1.00 67.81  ? 379 ALA A CA  1 
ATOM   2308 C C   . ALA A 1 379 ? 116.244 101.772 88.584  1.00 67.81  ? 379 ALA A C   1 
ATOM   2309 O O   . ALA A 1 379 ? 115.128 101.526 89.052  1.00 67.81  ? 379 ALA A O   1 
ATOM   2310 C CB  . ALA A 1 379 ? 117.717 100.600 90.217  1.00 67.81  ? 379 ALA A CB  1 
ATOM   2311 N N   . MET A 1 380 ? 116.535 102.917 87.969  1.00 67.77  ? 380 MET A N   1 
ATOM   2312 C CA  . MET A 1 380 ? 115.501 103.902 87.649  1.00 67.77  ? 380 MET A CA  1 
ATOM   2313 C C   . MET A 1 380 ? 114.389 103.371 86.731  1.00 67.77  ? 380 MET A C   1 
ATOM   2314 O O   . MET A 1 380 ? 113.209 103.503 87.110  1.00 67.77  ? 380 MET A O   1 
ATOM   2315 C CB  . MET A 1 380 ? 116.198 105.158 87.102  1.00 67.77  ? 380 MET A CB  1 
ATOM   2316 C CG  . MET A 1 380 ? 115.324 106.296 86.653  1.00 67.77  ? 380 MET A CG  1 
ATOM   2317 S SD  . MET A 1 380 ? 114.401 107.022 87.986  1.00 67.77  ? 380 MET A SD  1 
ATOM   2318 C CE  . MET A 1 380 ? 115.715 107.673 89.000  1.00 67.77  ? 380 MET A CE  1 
ATOM   2319 N N   . PRO A 1 381 ? 114.654 102.756 85.557  1.00 64.44  ? 381 PRO A N   1 
ATOM   2320 C CA  . PRO A 1 381 ? 113.514 102.310 84.738  1.00 64.44  ? 381 PRO A CA  1 
ATOM   2321 C C   . PRO A 1 381 ? 112.777 101.121 85.321  1.00 64.44  ? 381 PRO A C   1 
ATOM   2322 O O   . PRO A 1 381 ? 111.567 100.999 85.097  1.00 64.44  ? 381 PRO A O   1 
ATOM   2323 C CB  . PRO A 1 381 ? 114.158 101.957 83.391  1.00 64.44  ? 381 PRO A CB  1 
ATOM   2324 C CG  . PRO A 1 381 ? 115.462 102.613 83.397  1.00 64.44  ? 381 PRO A CG  1 
ATOM   2325 C CD  . PRO A 1 381 ? 115.903 102.508 84.809  1.00 64.44  ? 381 PRO A CD  1 
ATOM   2326 N N   . TYR A 1 382 ? 113.458 100.254 86.075  1.00 67.48  ? 382 TYR A N   1 
ATOM   2327 C CA  . TYR A 1 382 ? 112.753 99.167  86.745  1.00 67.48  ? 382 TYR A CA  1 
ATOM   2328 C C   . TYR A 1 382 ? 111.827 99.693  87.831  1.00 67.48  ? 382 TYR A C   1 
ATOM   2329 O O   . TYR A 1 382 ? 110.726 99.160  88.014  1.00 67.48  ? 382 TYR A O   1 
ATOM   2330 C CB  . TYR A 1 382 ? 113.742 98.164  87.334  1.00 67.48  ? 382 TYR A CB  1 
ATOM   2331 C CG  . TYR A 1 382 ? 114.449 97.304  86.314  1.00 67.48  ? 382 TYR A CG  1 
ATOM   2332 C CD1 . TYR A 1 382 ? 113.998 97.227  85.004  1.00 67.48  ? 382 TYR A CD1 1 
ATOM   2333 C CD2 . TYR A 1 382 ? 115.561 96.556  86.669  1.00 67.48  ? 382 TYR A CD2 1 
ATOM   2334 C CE1 . TYR A 1 382 ? 114.644 96.440  84.074  1.00 67.48  ? 382 TYR A CE1 1 
ATOM   2335 C CE2 . TYR A 1 382 ? 116.213 95.765  85.747  1.00 67.48  ? 382 TYR A CE2 1 
ATOM   2336 C CZ  . TYR A 1 382 ? 115.751 95.710  84.454  1.00 67.48  ? 382 TYR A CZ  1 
ATOM   2337 O OH  . TYR A 1 382 ? 116.402 94.919  83.536  1.00 67.48  ? 382 TYR A OH  1 
ATOM   2338 N N   . ARG A 1 383 ? 112.222 100.767 88.517  1.00 68.31  ? 383 ARG A N   1 
ATOM   2339 C CA  . ARG A 1 383 ? 111.340 101.356 89.517  1.00 68.31  ? 383 ARG A CA  1 
ATOM   2340 C C   . ARG A 1 383 ? 110.155 102.065 88.872  1.00 68.31  ? 383 ARG A C   1 
ATOM   2341 O O   . ARG A 1 383 ? 109.048 102.032 89.420  1.00 68.31  ? 383 ARG A O   1 
ATOM   2342 C CB  . ARG A 1 383 ? 112.125 102.311 90.409  1.00 68.31  ? 383 ARG A CB  1 
ATOM   2343 C CG  . ARG A 1 383 ? 111.358 102.806 91.618  1.00 68.31  ? 383 ARG A CG  1 
ATOM   2344 C CD  . ARG A 1 383 ? 112.277 103.534 92.573  1.00 68.31  ? 383 ARG A CD  1 
ATOM   2345 N NE  . ARG A 1 383 ? 111.574 104.041 93.741  1.00 68.31  ? 383 ARG A NE  1 
ATOM   2346 C CZ  . ARG A 1 383 ? 112.166 104.661 94.754  1.00 68.31  ? 383 ARG A CZ  1 
ATOM   2347 N NH1 . ARG A 1 383 ? 113.474 104.848 94.743  1.00 68.31  ? 383 ARG A NH1 1 
ATOM   2348 N NH2 . ARG A 1 383 ? 111.447 105.105 95.773  1.00 68.31  ? 383 ARG A NH2 1 
ATOM   2349 N N   . LEU A 1 384 ? 110.336 102.660 87.690  1.00 64.04  ? 384 LEU A N   1 
ATOM   2350 C CA  . LEU A 1 384 ? 109.174 103.257 87.027  1.00 64.04  ? 384 LEU A CA  1 
ATOM   2351 C C   . LEU A 1 384 ? 108.226 102.200 86.458  1.00 64.04  ? 384 LEU A C   1 
ATOM   2352 O O   . LEU A 1 384 ? 106.999 102.377 86.498  1.00 64.04  ? 384 LEU A O   1 
ATOM   2353 C CB  . LEU A 1 384 ? 109.610 104.229 85.938  1.00 64.04  ? 384 LEU A CB  1 
ATOM   2354 C CG  . LEU A 1 384 ? 109.763 105.680 86.394  1.00 64.04  ? 384 LEU A CG  1 
ATOM   2355 C CD1 . LEU A 1 384 ? 110.999 105.922 87.209  1.00 64.04  ? 384 LEU A CD1 1 
ATOM   2356 C CD2 . LEU A 1 384 ? 109.749 106.591 85.205  1.00 64.04  ? 384 LEU A CD2 1 
ATOM   2357 N N   . LEU A 1 385 ? 108.762 101.096 85.930  1.00 61.06  ? 385 LEU A N   1 
ATOM   2358 C CA  . LEU A 1 385 ? 107.883 100.015 85.488  1.00 61.06  ? 385 LEU A CA  1 
ATOM   2359 C C   . LEU A 1 385 ? 107.175 99.342  86.657  1.00 61.06  ? 385 LEU A C   1 
ATOM   2360 O O   . LEU A 1 385 ? 106.028 98.908  86.515  1.00 61.06  ? 385 LEU A O   1 
ATOM   2361 C CB  . LEU A 1 385 ? 108.653 98.988  84.660  1.00 61.06  ? 385 LEU A CB  1 
ATOM   2362 C CG  . LEU A 1 385 ? 108.633 99.199  83.142  1.00 61.06  ? 385 LEU A CG  1 
ATOM   2363 C CD1 . LEU A 1 385 ? 109.418 100.416 82.683  1.00 61.06  ? 385 LEU A CD1 1 
ATOM   2364 C CD2 . LEU A 1 385 ? 109.132 97.945  82.441  1.00 61.06  ? 385 LEU A CD2 1 
ATOM   2365 N N   . LEU A 1 386 ? 107.804 99.289  87.832  1.00 64.52  ? 386 LEU A N   1 
ATOM   2366 C CA  . LEU A 1 386 ? 107.064 98.835  89.004  1.00 64.52  ? 386 LEU A CA  1 
ATOM   2367 C C   . LEU A 1 386 ? 106.084 99.886  89.511  1.00 64.52  ? 386 LEU A C   1 
ATOM   2368 O O   . LEU A 1 386 ? 105.124 99.533  90.197  1.00 64.52  ? 386 LEU A O   1 
ATOM   2369 C CB  . LEU A 1 386 ? 108.028 98.407  90.105  1.00 64.52  ? 386 LEU A CB  1 
ATOM   2370 C CG  . LEU A 1 386 ? 108.736 97.111  89.712  1.00 64.52  ? 386 LEU A CG  1 
ATOM   2371 C CD1 . LEU A 1 386 ? 109.822 96.766  90.689  1.00 64.52  ? 386 LEU A CD1 1 
ATOM   2372 C CD2 . LEU A 1 386 ? 107.736 95.977  89.613  1.00 64.52  ? 386 LEU A CD2 1 
ATOM   2373 N N   . GLY A 1 387 ? 106.278 101.160 89.165  1.00 65.23  ? 387 GLY A N   1 
ATOM   2374 C CA  . GLY A 1 387 ? 105.225 102.141 89.393  1.00 65.23  ? 387 GLY A CA  1 
ATOM   2375 C C   . GLY A 1 387 ? 103.997 101.891 88.533  1.00 65.23  ? 387 GLY A C   1 
ATOM   2376 O O   . GLY A 1 387 ? 102.860 101.980 89.014  1.00 65.23  ? 387 GLY A O   1 
ATOM   2377 N N   . LEU A 1 388 ? 104.208 101.565 87.251  1.00 63.91  ? 388 LEU A N   1 
ATOM   2378 C CA  . LEU A 1 388 ? 103.084 101.117 86.420  1.00 63.91  ? 388 LEU A CA  1 
ATOM   2379 C C   . LEU A 1 388 ? 102.477 99.823  86.937  1.00 63.91  ? 388 LEU A C   1 
ATOM   2380 O O   . LEU A 1 388 ? 101.271 99.606  86.797  1.00 63.91  ? 388 LEU A O   1 
ATOM   2381 C CB  . LEU A 1 388 ? 103.478 100.885 84.964  1.00 63.91  ? 388 LEU A CB  1 
ATOM   2382 C CG  . LEU A 1 388 ? 103.530 102.005 83.939  1.00 63.91  ? 388 LEU A CG  1 
ATOM   2383 C CD1 . LEU A 1 388 ? 104.846 102.663 84.045  1.00 63.91  ? 388 LEU A CD1 1 
ATOM   2384 C CD2 . LEU A 1 388 ? 103.306 101.464 82.539  1.00 63.91  ? 388 LEU A CD2 1 
ATOM   2385 N N   . GLU A 1 389 ? 103.296 98.943  87.509  1.00 67.41  ? 389 GLU A N   1 
ATOM   2386 C CA  . GLU A 1 389 ? 102.768 97.705  88.066  1.00 67.41  ? 389 GLU A CA  1 
ATOM   2387 C C   . GLU A 1 389 ? 101.954 97.970  89.330  1.00 67.41  ? 389 GLU A C   1 
ATOM   2388 O O   . GLU A 1 389 ? 100.969 97.272  89.583  1.00 67.41  ? 389 GLU A O   1 
ATOM   2389 C CB  . GLU A 1 389 ? 103.920 96.734  88.319  1.00 67.41  ? 389 GLU A CB  1 
ATOM   2390 C CG  . GLU A 1 389 ? 103.524 95.300  88.580  1.00 67.41  ? 389 GLU A CG  1 
ATOM   2391 C CD  . GLU A 1 389 ? 103.320 95.033  90.038  1.00 67.41  ? 389 GLU A CD  1 
ATOM   2392 O OE1 . GLU A 1 389 ? 103.933 95.758  90.841  1.00 67.41  ? 389 GLU A OE1 1 
ATOM   2393 O OE2 . GLU A 1 389 ? 102.565 94.104  90.383  1.00 67.41  ? 389 GLU A OE2 1 
ATOM   2394 N N   . TYR A 1 390 ? 102.324 98.995  90.106  1.00 67.20  ? 390 TYR A N   1 
ATOM   2395 C CA  . TYR A 1 390 ? 101.466 99.459  91.195  1.00 67.20  ? 390 TYR A CA  1 
ATOM   2396 C C   . TYR A 1 390 ? 100.149 100.017 90.680  1.00 67.20  ? 390 TYR A C   1 
ATOM   2397 O O   . TYR A 1 390 ? 99.099  99.804  91.296  1.00 67.20  ? 390 TYR A O   1 
ATOM   2398 C CB  . TYR A 1 390 ? 102.159 100.531 92.029  1.00 67.20  ? 390 TYR A CB  1 
ATOM   2399 C CG  . TYR A 1 390 ? 103.109 100.039 93.081  1.00 67.20  ? 390 TYR A CG  1 
ATOM   2400 C CD1 . TYR A 1 390 ? 103.281 98.689  93.324  1.00 67.20  ? 390 TYR A CD1 1 
ATOM   2401 C CD2 . TYR A 1 390 ? 103.762 100.943 93.902  1.00 67.20  ? 390 TYR A CD2 1 
ATOM   2402 C CE1 . TYR A 1 390 ? 104.139 98.256  94.308  1.00 67.20  ? 390 TYR A CE1 1 
ATOM   2403 C CE2 . TYR A 1 390 ? 104.603 100.524 94.891  1.00 67.20  ? 390 TYR A CE2 1 
ATOM   2404 C CZ  . TYR A 1 390 ? 104.788 99.183  95.092  1.00 67.20  ? 390 TYR A CZ  1 
ATOM   2405 O OH  . TYR A 1 390 ? 105.630 98.775  96.093  1.00 67.20  ? 390 TYR A OH  1 
ATOM   2406 N N   . ALA A 1 391 ? 100.191 100.774 89.579  1.00 67.95  ? 391 ALA A N   1 
ATOM   2407 C CA  . ALA A 1 391 ? 98.955  101.303 89.002  1.00 67.95  ? 391 ALA A CA  1 
ATOM   2408 C C   . ALA A 1 391 ? 98.054  100.180 88.499  1.00 67.95  ? 391 ALA A C   1 
ATOM   2409 O O   . ALA A 1 391 ? 96.835  100.207 88.712  1.00 67.95  ? 391 ALA A O   1 
ATOM   2410 C CB  . ALA A 1 391 ? 99.274  102.280 87.873  1.00 67.95  ? 391 ALA A CB  1 
ATOM   2411 N N   . LEU A 1 392 ? 98.648  99.164  87.870  1.00 68.96  ? 392 LEU A N   1 
ATOM   2412 C CA  . LEU A 1 392 ? 97.902  97.981  87.453  1.00 68.96  ? 392 LEU A CA  1 
ATOM   2413 C C   . LEU A 1 392 ? 97.364  97.207  88.649  1.00 68.96  ? 392 LEU A C   1 
ATOM   2414 O O   . LEU A 1 392 ? 96.266  96.649  88.582  1.00 68.96  ? 392 LEU A O   1 
ATOM   2415 C CB  . LEU A 1 392 ? 98.792  97.084  86.596  1.00 68.96  ? 392 LEU A CB  1 
ATOM   2416 C CG  . LEU A 1 392 ? 98.165  95.825  86.003  1.00 68.96  ? 392 LEU A CG  1 
ATOM   2417 C CD1 . LEU A 1 392 ? 97.067  96.192  85.031  1.00 68.96  ? 392 LEU A CD1 1 
ATOM   2418 C CD2 . LEU A 1 392 ? 99.222  94.983  85.323  1.00 68.96  ? 392 LEU A CD2 1 
ATOM   2419 N N   . LEU A 1 393 ? 98.093  97.208  89.764  1.00 70.24  ? 393 LEU A N   1 
ATOM   2420 C CA  . LEU A 1 393 ? 97.649  96.485  90.951  1.00 70.24  ? 393 LEU A CA  1 
ATOM   2421 C C   . LEU A 1 393 ? 96.481  97.191  91.634  1.00 70.24  ? 393 LEU A C   1 
ATOM   2422 O O   . LEU A 1 393 ? 95.540  96.539  92.103  1.00 70.24  ? 393 LEU A O   1 
ATOM   2423 C CB  . LEU A 1 393 ? 98.829  96.328  91.899  1.00 70.24  ? 393 LEU A CB  1 
ATOM   2424 C CG  . LEU A 1 393 ? 98.689  95.491  93.153  1.00 70.24  ? 393 LEU A CG  1 
ATOM   2425 C CD1 . LEU A 1 393 ? 98.346  94.069  92.789  1.00 70.24  ? 393 LEU A CD1 1 
ATOM   2426 C CD2 . LEU A 1 393 ? 100.019 95.549  93.828  1.00 70.24  ? 393 LEU A CD2 1 
ATOM   2427 N N   . VAL A 1 394 ? 96.519  98.524  91.689  1.00 68.76  ? 394 VAL A N   1 
ATOM   2428 C CA  . VAL A 1 394 ? 95.382  99.280  92.207  1.00 68.76  ? 394 VAL A CA  1 
ATOM   2429 C C   . VAL A 1 394 ? 94.187  99.156  91.267  1.00 68.76  ? 394 VAL A C   1 
ATOM   2430 O O   . VAL A 1 394 ? 93.037  99.106  91.719  1.00 68.76  ? 394 VAL A O   1 
ATOM   2431 C CB  . VAL A 1 394 ? 95.799  100.743 92.450  1.00 68.76  ? 394 VAL A CB  1 
ATOM   2432 C CG1 . VAL A 1 394 ? 94.632  101.612 92.880  1.00 68.76  ? 394 VAL A CG1 1 
ATOM   2433 C CG2 . VAL A 1 394 ? 96.852  100.788 93.516  1.00 68.76  ? 394 VAL A CG2 1 
ATOM   2434 N N   . TRP A 1 395 ? 94.430  99.043  89.958  1.00 72.33  ? 395 TRP A N   1 
ATOM   2435 C CA  . TRP A 1 395 ? 93.336  98.775  89.030  1.00 72.33  ? 395 TRP A CA  1 
ATOM   2436 C C   . TRP A 1 395 ? 92.769  97.371  89.209  1.00 72.33  ? 395 TRP A C   1 
ATOM   2437 O O   . TRP A 1 395 ? 91.574  97.153  88.987  1.00 72.33  ? 395 TRP A O   1 
ATOM   2438 C CB  . TRP A 1 395 ? 93.809  98.970  87.594  1.00 72.33  ? 395 TRP A CB  1 
ATOM   2439 C CG  . TRP A 1 395 ? 92.736  98.751  86.597  1.00 72.33  ? 395 TRP A CG  1 
ATOM   2440 C CD1 . TRP A 1 395 ? 91.623  99.511  86.415  1.00 72.33  ? 395 TRP A CD1 1 
ATOM   2441 C CD2 . TRP A 1 395 ? 92.652  97.682  85.655  1.00 72.33  ? 395 TRP A CD2 1 
ATOM   2442 N NE1 . TRP A 1 395 ? 90.854  98.990  85.406  1.00 72.33  ? 395 TRP A NE1 1 
ATOM   2443 C CE2 . TRP A 1 395 ? 91.465  97.864  84.923  1.00 72.33  ? 395 TRP A CE2 1 
ATOM   2444 C CE3 . TRP A 1 395 ? 93.468  96.591  85.354  1.00 72.33  ? 395 TRP A CE3 1 
ATOM   2445 C CZ2 . TRP A 1 395 ? 91.074  96.996  83.909  1.00 72.33  ? 395 TRP A CZ2 1 
ATOM   2446 C CZ3 . TRP A 1 395 ? 93.081  95.730  84.349  1.00 72.33  ? 395 TRP A CZ3 1 
ATOM   2447 C CH2 . TRP A 1 395 ? 91.894  95.937  83.637  1.00 72.33  ? 395 TRP A CH2 1 
ATOM   2448 N N   . TRP A 1 396 ? 93.601  96.417  89.618  1.00 79.10  ? 396 TRP A N   1 
ATOM   2449 C CA  . TRP A 1 396 ? 93.166  95.035  89.771  1.00 79.10  ? 396 TRP A CA  1 
ATOM   2450 C C   . TRP A 1 396 ? 92.509  94.772  91.121  1.00 79.10  ? 396 TRP A C   1 
ATOM   2451 O O   . TRP A 1 396 ? 91.792  93.774  91.260  1.00 79.10  ? 396 TRP A O   1 
ATOM   2452 C CB  . TRP A 1 396 ? 94.372  94.115  89.550  1.00 79.10  ? 396 TRP A CB  1 
ATOM   2453 C CG  . TRP A 1 396 ? 94.089  92.652  89.597  1.00 79.10  ? 396 TRP A CG  1 
ATOM   2454 C CD1 . TRP A 1 396 ? 93.208  91.963  88.820  1.00 79.10  ? 396 TRP A CD1 1 
ATOM   2455 C CD2 . TRP A 1 396 ? 94.732  91.686  90.430  1.00 79.10  ? 396 TRP A CD2 1 
ATOM   2456 N NE1 . TRP A 1 396 ? 93.240  90.629  89.140  1.00 79.10  ? 396 TRP A NE1 1 
ATOM   2457 C CE2 . TRP A 1 396 ? 94.172  90.433  90.124  1.00 79.10  ? 396 TRP A CE2 1 
ATOM   2458 C CE3 . TRP A 1 396 ? 95.719  91.761  91.413  1.00 79.10  ? 396 TRP A CE3 1 
ATOM   2459 C CZ2 . TRP A 1 396 ? 94.566  89.266  90.765  1.00 79.10  ? 396 TRP A CZ2 1 
ATOM   2460 C CZ3 . TRP A 1 396 ? 96.111  90.603  92.044  1.00 79.10  ? 396 TRP A CZ3 1 
ATOM   2461 C CH2 . TRP A 1 396 ? 95.534  89.373  91.723  1.00 79.10  ? 396 TRP A CH2 1 
ATOM   2462 N N   . THR A 1 397 ? 92.734  95.647  92.103  1.00 76.69  ? 397 THR A N   1 
ATOM   2463 C CA  . THR A 1 397 ? 92.135  95.471  93.428  1.00 76.69  ? 397 THR A CA  1 
ATOM   2464 C C   . THR A 1 397 ? 90.596  95.457  93.468  1.00 76.69  ? 397 THR A C   1 
ATOM   2465 O O   . THR A 1 397 ? 90.053  94.571  94.152  1.00 76.69  ? 397 THR A O   1 
ATOM   2466 C CB  . THR A 1 397 ? 92.721  96.526  94.383  1.00 76.69  ? 397 THR A CB  1 
ATOM   2467 O OG1 . THR A 1 397 ? 94.138  96.345  94.468  1.00 76.69  ? 397 THR A OG1 1 
ATOM   2468 C CG2 . THR A 1 397 ? 92.139  96.410  95.777  1.00 76.69  ? 397 THR A CG2 1 
ATOM   2469 N N   . PRO A 1 398 ? 89.834  96.330  92.776  1.00 76.42  ? 398 PRO A N   1 
ATOM   2470 C CA  . PRO A 1 398 ? 88.367  96.174  92.828  1.00 76.42  ? 398 PRO A CA  1 
ATOM   2471 C C   . PRO A 1 398 ? 87.845  94.958  92.087  1.00 76.42  ? 398 PRO A C   1 
ATOM   2472 O O   . PRO A 1 398 ? 86.694  94.567  92.312  1.00 76.42  ? 398 PRO A O   1 
ATOM   2473 C CB  . PRO A 1 398 ? 87.842  97.457  92.171  1.00 76.42  ? 398 PRO A CB  1 
ATOM   2474 C CG  . PRO A 1 398 ? 88.931  98.389  92.224  1.00 76.42  ? 398 PRO A CG  1 
ATOM   2475 C CD  . PRO A 1 398 ? 90.164  97.582  92.070  1.00 76.42  ? 398 PRO A CD  1 
ATOM   2476 N N   . LYS A 1 399 ? 88.637  94.356  91.207  1.00 78.85  ? 399 LYS A N   1 
ATOM   2477 C CA  . LYS A 1 399 ? 88.191  93.217  90.424  1.00 78.85  ? 399 LYS A CA  1 
ATOM   2478 C C   . LYS A 1 399 ? 88.412  91.888  91.136  1.00 78.85  ? 399 LYS A C   1 
ATOM   2479 O O   . LYS A 1 399 ? 88.200  90.832  90.532  1.00 78.85  ? 399 LYS A O   1 
ATOM   2480 C CB  . LYS A 1 399 ? 88.892  93.217  89.065  1.00 78.85  ? 399 LYS A CB  1 
ATOM   2481 C CG  . LYS A 1 399 ? 88.495  94.394  88.185  1.00 78.85  ? 399 LYS A CG  1 
ATOM   2482 C CD  . LYS A 1 399 ? 89.268  94.407  86.878  1.00 78.85  ? 399 LYS A CD  1 
ATOM   2483 C CE  . LYS A 1 399 ? 88.815  93.286  85.958  1.00 78.85  ? 399 LYS A CE  1 
ATOM   2484 N NZ  . LYS A 1 399 ? 87.423  93.497  85.476  1.00 78.85  ? 399 LYS A NZ  1 
ATOM   2485 N N   . VAL A 1 400 ? 88.831  91.914  92.399  1.00 82.31  ? 400 VAL A N   1 
ATOM   2486 C CA  . VAL A 1 400 ? 88.952  90.708  93.205  1.00 82.31  ? 400 VAL A CA  1 
ATOM   2487 C C   . VAL A 1 400 ? 87.981  90.837  94.375  1.00 82.31  ? 400 VAL A C   1 
ATOM   2488 O O   . VAL A 1 400 ? 87.634  91.943  94.801  1.00 82.31  ? 400 VAL A O   1 
ATOM   2489 C CB  . VAL A 1 400 ? 90.413  90.471  93.669  1.00 82.31  ? 400 VAL A CB  1 
ATOM   2490 C CG1 . VAL A 1 400 ? 90.827  91.423  94.777  1.00 82.31  ? 400 VAL A CG1 1 
ATOM   2491 C CG2 . VAL A 1 400 ? 90.651  89.022  94.049  1.00 82.31  ? 400 VAL A CG2 1 
ATOM   2492 N N   . GLU A 1 401 ? 87.500  89.696  94.861  1.00 89.65  ? 401 GLU A N   1 
ATOM   2493 C CA  . GLU A 1 401 ? 86.400  89.679  95.816  1.00 89.65  ? 401 GLU A CA  1 
ATOM   2494 C C   . GLU A 1 401 ? 86.889  90.012  97.220  1.00 89.65  ? 401 GLU A C   1 
ATOM   2495 O O   . GLU A 1 401 ? 87.890  89.462  97.687  1.00 89.65  ? 401 GLU A O   1 
ATOM   2496 C CB  . GLU A 1 401 ? 85.710  88.315  95.804  1.00 89.65  ? 401 GLU A CB  1 
ATOM   2497 C CG  . GLU A 1 401 ? 84.929  88.014  94.528  1.00 89.65  ? 401 GLU A CG  1 
ATOM   2498 C CD  . GLU A 1 401 ? 85.795  87.454  93.411  1.00 89.65  ? 401 GLU A CD  1 
ATOM   2499 O OE1 . GLU A 1 401 ? 87.003  87.230  93.640  1.00 89.65  ? 401 GLU A OE1 1 
ATOM   2500 O OE2 . GLU A 1 401 ? 85.267  87.243  92.300  1.00 89.65  ? 401 GLU A OE2 1 
ATOM   2501 N N   . HIS A 1 402 ? 86.170  90.909  97.892  1.00 88.13  ? 402 HIS A N   1 
ATOM   2502 C CA  . HIS A 1 402 ? 86.508  91.319  99.249  1.00 88.13  ? 402 HIS A CA  1 
ATOM   2503 C C   . HIS A 1 402 ? 85.734  90.550  100.309 1.00 88.13  ? 402 HIS A C   1 
ATOM   2504 O O   . HIS A 1 402 ? 86.204  90.440  101.448 1.00 88.13  ? 402 HIS A O   1 
ATOM   2505 C CB  . HIS A 1 402 ? 86.227  92.812  99.433  1.00 88.13  ? 402 HIS A CB  1 
ATOM   2506 C CG  . HIS A 1 402 ? 87.013  93.693  98.519  1.00 88.13  ? 402 HIS A CG  1 
ATOM   2507 N ND1 . HIS A 1 402 ? 88.347  93.971  98.718  1.00 88.13  ? 402 HIS A ND1 1 
ATOM   2508 C CD2 . HIS A 1 402 ? 86.652  94.364  97.400  1.00 88.13  ? 402 HIS A CD2 1 
ATOM   2509 C CE1 . HIS A 1 402 ? 88.776  94.769  97.758  1.00 88.13  ? 402 HIS A CE1 1 
ATOM   2510 N NE2 . HIS A 1 402 ? 87.766  95.026  96.947  1.00 88.13  ? 402 HIS A NE2 1 
ATOM   2511 N N   . GLN A 1 403 ? 84.560  90.029  99.960  1.00 98.93  ? 403 GLN A N   1 
ATOM   2512 C CA  . GLN A 1 403 ? 83.659  89.446  100.946 1.00 98.93  ? 403 GLN A CA  1 
ATOM   2513 C C   . GLN A 1 403 ? 84.185  88.105  101.439 1.00 98.93  ? 403 GLN A C   1 
ATOM   2514 O O   . GLN A 1 403 ? 84.681  87.291  100.654 1.00 98.93  ? 403 GLN A O   1 
ATOM   2515 C CB  . GLN A 1 403 ? 82.266  89.273  100.345 1.00 98.93  ? 403 GLN A CB  1 
ATOM   2516 C CG  . GLN A 1 403 ? 81.563  90.575  100.014 1.00 98.93  ? 403 GLN A CG  1 
ATOM   2517 C CD  . GLN A 1 403 ? 80.196  90.352  99.399  1.00 98.93  ? 403 GLN A CD  1 
ATOM   2518 O OE1 . GLN A 1 403 ? 79.793  89.216  99.153  1.00 98.93  ? 403 GLN A OE1 1 
ATOM   2519 N NE2 . GLN A 1 403 ? 79.474  91.438  99.150  1.00 98.93  ? 403 GLN A NE2 1 
ATOM   2520 N N   . GLY A 1 404 ? 84.076  87.878  102.745 1.00 97.09  ? 404 GLY A N   1 
ATOM   2521 C CA  . GLY A 1 404 ? 84.511  86.630  103.335 1.00 97.09  ? 404 GLY A CA  1 
ATOM   2522 C C   . GLY A 1 404 ? 86.016  86.538  103.450 1.00 97.09  ? 404 GLY A C   1 
ATOM   2523 O O   . GLY A 1 404 ? 86.678  87.516  103.810 1.00 97.09  ? 404 GLY A O   1 
ATOM   2524 N N   . GLY A 1 405 ? 86.567  85.366  103.145 1.00 97.63  ? 405 GLY A N   1 
ATOM   2525 C CA  . GLY A 1 405 ? 88.004  85.179  103.201 1.00 97.63  ? 405 GLY A CA  1 
ATOM   2526 C C   . GLY A 1 405 ? 88.683  85.891  102.049 1.00 97.63  ? 405 GLY A C   1 
ATOM   2527 O O   . GLY A 1 405 ? 88.457  85.543  100.877 1.00 97.63  ? 405 GLY A O   1 
ATOM   2528 N N   . PHE A 1 406 ? 89.507  86.885  102.356 1.00 88.65  ? 406 PHE A N   1 
ATOM   2529 C CA  . PHE A 1 406 ? 90.192  87.640  101.319 1.00 88.65  ? 406 PHE A CA  1 
ATOM   2530 C C   . PHE A 1 406 ? 91.324  86.785  100.745 1.00 88.65  ? 406 PHE A C   1 
ATOM   2531 O O   . PHE A 1 406 ? 92.041  86.122  101.503 1.00 88.65  ? 406 PHE A O   1 
ATOM   2532 C CB  . PHE A 1 406 ? 90.728  88.946  101.907 1.00 88.65  ? 406 PHE A CB  1 
ATOM   2533 C CG  . PHE A 1 406 ? 91.107  89.972  100.883 1.00 88.65  ? 406 PHE A CG  1 
ATOM   2534 C CD1 . PHE A 1 406 ? 90.138  90.678  100.197 1.00 88.65  ? 406 PHE A CD1 1 
ATOM   2535 C CD2 . PHE A 1 406 ? 92.431  90.247  100.618 1.00 88.65  ? 406 PHE A CD2 1 
ATOM   2536 C CE1 . PHE A 1 406 ? 90.488  91.626  99.258  1.00 88.65  ? 406 PHE A CE1 1 
ATOM   2537 C CE2 . PHE A 1 406 ? 92.778  91.197  99.690  1.00 88.65  ? 406 PHE A CE2 1 
ATOM   2538 C CZ  . PHE A 1 406 ? 91.808  91.887  99.007  1.00 88.65  ? 406 PHE A CZ  1 
ATOM   2539 N N   . PRO A 1 407 ? 91.493  86.755  99.421  1.00 81.89  ? 407 PRO A N   1 
ATOM   2540 C CA  . PRO A 1 407 ? 92.299  85.693  98.806  1.00 81.89  ? 407 PRO A CA  1 
ATOM   2541 C C   . PRO A 1 407 ? 93.796  85.886  98.996  1.00 81.89  ? 407 PRO A C   1 
ATOM   2542 O O   . PRO A 1 407 ? 94.291  87.010  99.096  1.00 81.89  ? 407 PRO A O   1 
ATOM   2543 C CB  . PRO A 1 407 ? 91.919  85.781  97.328  1.00 81.89  ? 407 PRO A CB  1 
ATOM   2544 C CG  . PRO A 1 407 ? 91.532  87.187  97.142  1.00 81.89  ? 407 PRO A CG  1 
ATOM   2545 C CD  . PRO A 1 407 ? 90.858  87.608  98.404  1.00 81.89  ? 407 PRO A CD  1 
ATOM   2546 N N   . ILE A 1 408 ? 94.512  84.759  99.030  1.00 76.99  ? 408 ILE A N   1 
ATOM   2547 C CA  . ILE A 1 408 ? 95.943  84.770  99.313  1.00 76.99  ? 408 ILE A CA  1 
ATOM   2548 C C   . ILE A 1 408 ? 96.762  84.977  98.047  1.00 76.99  ? 408 ILE A C   1 
ATOM   2549 O O   . ILE A 1 408 ? 97.941  85.348  98.123  1.00 76.99  ? 408 ILE A O   1 
ATOM   2550 C CB  . ILE A 1 408 ? 96.352  83.473  100.033 1.00 76.99  ? 408 ILE A CB  1 
ATOM   2551 C CG1 . ILE A 1 408 ? 96.012  82.254  99.172  1.00 76.99  ? 408 ILE A CG1 1 
ATOM   2552 C CG2 . ILE A 1 408 ? 95.682  83.383  101.390 1.00 76.99  ? 408 ILE A CG2 1 
ATOM   2553 C CD1 . ILE A 1 408 ? 96.553  80.950  99.709  1.00 76.99  ? 408 ILE A CD1 1 
ATOM   2554 N N   . TYR A 1 409 ? 96.179  84.740  96.867  1.00 78.82  ? 409 TYR A N   1 
ATOM   2555 C CA  . TYR A 1 409 ? 96.938  85.003  95.650  1.00 78.82  ? 409 TYR A CA  1 
ATOM   2556 C C   . TYR A 1 409 ? 97.082  86.496  95.411  1.00 78.82  ? 409 TYR A C   1 
ATOM   2557 O O   . TYR A 1 409 ? 98.106  86.935  94.874  1.00 78.82  ? 409 TYR A O   1 
ATOM   2558 C CB  . TYR A 1 409 ? 96.316  84.307  94.432  1.00 78.82  ? 409 TYR A CB  1 
ATOM   2559 C CG  . TYR A 1 409 ? 94.951  84.780  93.978  1.00 78.82  ? 409 TYR A CG  1 
ATOM   2560 C CD1 . TYR A 1 409 ? 94.820  85.785  93.025  1.00 78.82  ? 409 TYR A CD1 1 
ATOM   2561 C CD2 . TYR A 1 409 ? 93.796  84.183  94.460  1.00 78.82  ? 409 TYR A CD2 1 
ATOM   2562 C CE1 . TYR A 1 409 ? 93.578  86.205  92.597  1.00 78.82  ? 409 TYR A CE1 1 
ATOM   2563 C CE2 . TYR A 1 409 ? 92.549  84.591  94.028  1.00 78.82  ? 409 TYR A CE2 1 
ATOM   2564 C CZ  . TYR A 1 409 ? 92.447  85.603  93.102  1.00 78.82  ? 409 TYR A CZ  1 
ATOM   2565 O OH  . TYR A 1 409 ? 91.207  86.013  92.675  1.00 78.82  ? 409 TYR A OH  1 
ATOM   2566 N N   . TYR A 1 410 ? 96.092  87.285  95.838  1.00 76.18  ? 410 TYR A N   1 
ATOM   2567 C CA  . TYR A 1 410 ? 96.252  88.734  95.852  1.00 76.18  ? 410 TYR A CA  1 
ATOM   2568 C C   . TYR A 1 410 ? 97.400  89.144  96.759  1.00 76.18  ? 410 TYR A C   1 
ATOM   2569 O O   . TYR A 1 410 ? 98.183  90.031  96.406  1.00 76.18  ? 410 TYR A O   1 
ATOM   2570 C CB  . TYR A 1 410 ? 94.965  89.415  96.309  1.00 76.18  ? 410 TYR A CB  1 
ATOM   2571 C CG  . TYR A 1 410 ? 95.018  90.929  96.260  1.00 76.18  ? 410 TYR A CG  1 
ATOM   2572 C CD1 . TYR A 1 410 ? 94.794  91.609  95.078  1.00 76.18  ? 410 TYR A CD1 1 
ATOM   2573 C CD2 . TYR A 1 410 ? 95.305  91.673  97.396  1.00 76.18  ? 410 TYR A CD2 1 
ATOM   2574 C CE1 . TYR A 1 410 ? 94.842  92.986  95.029  1.00 76.18  ? 410 TYR A CE1 1 
ATOM   2575 C CE2 . TYR A 1 410 ? 95.357  93.043  97.357  1.00 76.18  ? 410 TYR A CE2 1 
ATOM   2576 C CZ  . TYR A 1 410 ? 95.126  93.693  96.175  1.00 76.18  ? 410 TYR A CZ  1 
ATOM   2577 O OH  . TYR A 1 410 ? 95.179  95.062  96.142  1.00 76.18  ? 410 TYR A OH  1 
ATOM   2578 N N   . TYR A 1 411 ? 97.529  88.498  97.923  1.00 76.67  ? 411 TYR A N   1 
ATOM   2579 C CA  . TYR A 1 411 ? 98.613  88.868  98.823  1.00 76.67  ? 411 TYR A CA  1 
ATOM   2580 C C   . TYR A 1 411 ? 99.971  88.424  98.306  1.00 76.67  ? 411 TYR A C   1 
ATOM   2581 O O   . TYR A 1 411 ? 100.958 89.130  98.516  1.00 76.67  ? 411 TYR A O   1 
ATOM   2582 C CB  . TYR A 1 411 ? 98.394  88.331  100.231 1.00 76.67  ? 411 TYR A CB  1 
ATOM   2583 C CG  . TYR A 1 411 ? 97.325  89.069  100.981 1.00 76.67  ? 411 TYR A CG  1 
ATOM   2584 C CD1 . TYR A 1 411 ? 97.481  90.413  101.293 1.00 76.67  ? 411 TYR A CD1 1 
ATOM   2585 C CD2 . TYR A 1 411 ? 96.203  88.411  101.447 1.00 76.67  ? 411 TYR A CD2 1 
ATOM   2586 C CE1 . TYR A 1 411 ? 96.516  91.096  101.994 1.00 76.67  ? 411 TYR A CE1 1 
ATOM   2587 C CE2 . TYR A 1 411 ? 95.241  89.078  102.163 1.00 76.67  ? 411 TYR A CE2 1 
ATOM   2588 C CZ  . TYR A 1 411 ? 95.398  90.422  102.430 1.00 76.67  ? 411 TYR A CZ  1 
ATOM   2589 O OH  . TYR A 1 411 ? 94.430  91.090  103.141 1.00 76.67  ? 411 TYR A OH  1 
ATOM   2590 N N   . ILE A 1 412 ? 100.048 87.293  97.602  1.00 72.74  ? 412 ILE A N   1 
ATOM   2591 C CA  . ILE A 1 412 ? 101.355 86.904  97.081  1.00 72.74  ? 412 ILE A CA  1 
ATOM   2592 C C   . ILE A 1 412 ? 101.726 87.770  95.874  1.00 72.74  ? 412 ILE A C   1 
ATOM   2593 O O   . ILE A 1 412 ? 102.909 88.079  95.675  1.00 72.74  ? 412 ILE A O   1 
ATOM   2594 C CB  . ILE A 1 412 ? 101.415 85.388  96.789  1.00 72.74  ? 412 ILE A CB  1 
ATOM   2595 C CG1 . ILE A 1 412 ? 102.867 84.924  96.715  1.00 72.74  ? 412 ILE A CG1 1 
ATOM   2596 C CG2 . ILE A 1 412 ? 100.703 84.999  95.504  1.00 72.74  ? 412 ILE A CG2 1 
ATOM   2597 C CD1 . ILE A 1 412 ? 103.596 85.032  98.030  1.00 72.74  ? 412 ILE A CD1 1 
ATOM   2598 N N   . VAL A 1 413 ? 100.732 88.265  95.120  1.00 70.60  ? 413 VAL A N   1 
ATOM   2599 C CA  . VAL A 1 413 ? 101.014 89.196  94.028  1.00 70.60  ? 413 VAL A CA  1 
ATOM   2600 C C   . VAL A 1 413 ? 101.480 90.540  94.574  1.00 70.60  ? 413 VAL A C   1 
ATOM   2601 O O   . VAL A 1 413 ? 102.501 91.080  94.130  1.00 70.60  ? 413 VAL A O   1 
ATOM   2602 C CB  . VAL A 1 413 ? 99.787  89.346  93.110  1.00 70.60  ? 413 VAL A CB  1 
ATOM   2603 C CG1 . VAL A 1 413 ? 99.926  90.557  92.209  1.00 70.60  ? 413 VAL A CG1 1 
ATOM   2604 C CG2 . VAL A 1 413 ? 99.650  88.116  92.239  1.00 70.60  ? 413 VAL A CG2 1 
ATOM   2605 N N   . VAL A 1 414 ? 100.773 91.081  95.572  1.00 72.26  ? 414 VAL A N   1 
ATOM   2606 C CA  . VAL A 1 414 ? 101.171 92.377  96.122  1.00 72.26  ? 414 VAL A CA  1 
ATOM   2607 C C   . VAL A 1 414 ? 102.459 92.249  96.938  1.00 72.26  ? 414 VAL A C   1 
ATOM   2608 O O   . VAL A 1 414 ? 103.243 93.200  97.015  1.00 72.26  ? 414 VAL A O   1 
ATOM   2609 C CB  . VAL A 1 414 ? 100.010 93.004  96.930  1.00 72.26  ? 414 VAL A CB  1 
ATOM   2610 C CG1 . VAL A 1 414 ? 99.744  92.254  98.173  1.00 72.26  ? 414 VAL A CG1 1 
ATOM   2611 C CG2 . VAL A 1 414 ? 100.285 94.438  97.290  1.00 72.26  ? 414 VAL A CG2 1 
ATOM   2612 N N   . LEU A 1 415 ? 102.765 91.058  97.465  1.00 72.36  ? 415 LEU A N   1 
ATOM   2613 C CA  . LEU A 1 415 ? 104.003 90.905  98.216  1.00 72.36  ? 415 LEU A CA  1 
ATOM   2614 C C   . LEU A 1 415 ? 105.198 90.776  97.284  1.00 72.36  ? 415 LEU A C   1 
ATOM   2615 O O   . LEU A 1 415 ? 106.257 91.336  97.570  1.00 72.36  ? 415 LEU A O   1 
ATOM   2616 C CB  . LEU A 1 415 ? 103.906 89.711  99.166  1.00 72.36  ? 415 LEU A CB  1 
ATOM   2617 C CG  . LEU A 1 415 ? 104.965 89.574  100.267 1.00 72.36  ? 415 LEU A CG  1 
ATOM   2618 C CD1 . LEU A 1 415 ? 104.298 89.000  101.492 1.00 72.36  ? 415 LEU A CD1 1 
ATOM   2619 C CD2 . LEU A 1 415 ? 106.133 88.677  99.867  1.00 72.36  ? 415 LEU A CD2 1 
ATOM   2620 N N   . LEU A 1 416 ? 105.054 90.064  96.157  1.00 68.73  ? 416 LEU A N   1 
ATOM   2621 C CA  . LEU A 1 416 ? 106.131 90.065  95.166  1.00 68.73  ? 416 LEU A CA  1 
ATOM   2622 C C   . LEU A 1 416 ? 106.286 91.435  94.521  1.00 68.73  ? 416 LEU A C   1 
ATOM   2623 O O   . LEU A 1 416 ? 107.407 91.850  94.199  1.00 68.73  ? 416 LEU A O   1 
ATOM   2624 C CB  . LEU A 1 416 ? 105.890 89.001  94.097  1.00 68.73  ? 416 LEU A CB  1 
ATOM   2625 C CG  . LEU A 1 416 ? 106.084 87.549  94.518  1.00 68.73  ? 416 LEU A CG  1 
ATOM   2626 C CD1 . LEU A 1 416 ? 105.688 86.619  93.386  1.00 68.73  ? 416 LEU A CD1 1 
ATOM   2627 C CD2 . LEU A 1 416 ? 107.527 87.322  94.916  1.00 68.73  ? 416 LEU A CD2 1 
ATOM   2628 N N   . SER A 1 417 ? 105.178 92.163  94.363  1.00 69.13  ? 417 SER A N   1 
ATOM   2629 C CA  . SER A 1 417 ? 105.224 93.511  93.810  1.00 69.13  ? 417 SER A CA  1 
ATOM   2630 C C   . SER A 1 417 ? 105.978 94.463  94.729  1.00 69.13  ? 417 SER A C   1 
ATOM   2631 O O   . SER A 1 417 ? 106.907 95.158  94.300  1.00 69.13  ? 417 SER A O   1 
ATOM   2632 C CB  . SER A 1 417 ? 103.803 94.006  93.576  1.00 69.13  ? 417 SER A CB  1 
ATOM   2633 O OG  . SER A 1 417 ? 103.809 95.335  93.107  1.00 69.13  ? 417 SER A OG  1 
ATOM   2634 N N   . TYR A 1 418 ? 105.606 94.481  96.010  1.00 72.17  ? 418 TYR A N   1 
ATOM   2635 C CA  . TYR A 1 418 ? 106.304 95.300  96.991  1.00 72.17  ? 418 TYR A CA  1 
ATOM   2636 C C   . TYR A 1 418 ? 107.722 94.809  97.228  1.00 72.17  ? 418 TYR A C   1 
ATOM   2637 O O   . TYR A 1 418 ? 108.597 95.612  97.552  1.00 72.17  ? 418 TYR A O   1 
ATOM   2638 C CB  . TYR A 1 418 ? 105.525 95.305  98.298  1.00 72.17  ? 418 TYR A CB  1 
ATOM   2639 C CG  . TYR A 1 418 ? 106.067 96.217  99.372  1.00 72.17  ? 418 TYR A CG  1 
ATOM   2640 C CD1 . TYR A 1 418 ? 105.833 97.581  99.326  1.00 72.17  ? 418 TYR A CD1 1 
ATOM   2641 C CD2 . TYR A 1 418 ? 106.794 95.710  100.440 1.00 72.17  ? 418 TYR A CD2 1 
ATOM   2642 C CE1 . TYR A 1 418 ? 106.311 98.418  100.309 1.00 72.17  ? 418 TYR A CE1 1 
ATOM   2643 C CE2 . TYR A 1 418 ? 107.273 96.540  101.431 1.00 72.17  ? 418 TYR A CE2 1 
ATOM   2644 C CZ  . TYR A 1 418 ? 107.030 97.893  101.357 1.00 72.17  ? 418 TYR A CZ  1 
ATOM   2645 O OH  . TYR A 1 418 ? 107.510 98.730  102.335 1.00 72.17  ? 418 TYR A OH  1 
ATOM   2646 N N   . ALA A 1 419 ? 107.982 93.514  97.029  1.00 72.22  ? 419 ALA A N   1 
ATOM   2647 C CA  . ALA A 1 419 ? 109.327 92.989  97.213  1.00 72.22  ? 419 ALA A CA  1 
ATOM   2648 C C   . ALA A 1 419 ? 110.262 93.477  96.119  1.00 72.22  ? 419 ALA A C   1 
ATOM   2649 O O   . ALA A 1 419 ? 111.354 93.965  96.412  1.00 72.22  ? 419 ALA A O   1 
ATOM   2650 C CB  . ALA A 1 419 ? 109.299 91.462  97.258  1.00 72.22  ? 419 ALA A CB  1 
ATOM   2651 N N   . LEU A 1 420 ? 109.846 93.367  94.854  1.00 68.41  ? 420 LEU A N   1 
ATOM   2652 C CA  . LEU A 1 420 ? 110.668 93.888  93.763  1.00 68.41  ? 420 LEU A CA  1 
ATOM   2653 C C   . LEU A 1 420 ? 110.781 95.406  93.821  1.00 68.41  ? 420 LEU A C   1 
ATOM   2654 O O   . LEU A 1 420 ? 111.853 95.969  93.535  1.00 68.41  ? 420 LEU A O   1 
ATOM   2655 C CB  . LEU A 1 420 ? 110.112 93.440  92.411  1.00 68.41  ? 420 LEU A CB  1 
ATOM   2656 C CG  . LEU A 1 420 ? 110.623 92.117  91.831  1.00 68.41  ? 420 LEU A CG  1 
ATOM   2657 C CD1 . LEU A 1 420 ? 110.130 90.891  92.576  1.00 68.41  ? 420 LEU A CD1 1 
ATOM   2658 C CD2 . LEU A 1 420 ? 110.261 92.023  90.358  1.00 68.41  ? 420 LEU A CD2 1 
ATOM   2659 N N   . HIS A 1 421 ? 109.703 96.085  94.227  1.00 67.68  ? 421 HIS A N   1 
ATOM   2660 C CA  . HIS A 1 421 ? 109.758 97.536  94.342  1.00 67.68  ? 421 HIS A CA  1 
ATOM   2661 C C   . HIS A 1 421 ? 110.680 97.972  95.473  1.00 67.68  ? 421 HIS A C   1 
ATOM   2662 O O   . HIS A 1 421 ? 111.405 98.953  95.333  1.00 67.68  ? 421 HIS A O   1 
ATOM   2663 C CB  . HIS A 1 421 ? 108.358 98.098  94.539  1.00 67.68  ? 421 HIS A CB  1 
ATOM   2664 C CG  . HIS A 1 421 ? 108.290 99.590  94.504  1.00 67.68  ? 421 HIS A CG  1 
ATOM   2665 N ND1 . HIS A 1 421 ? 108.516 100.372 95.614  1.00 67.68  ? 421 HIS A ND1 1 
ATOM   2666 C CD2 . HIS A 1 421 ? 108.009 100.445 93.494  1.00 67.68  ? 421 HIS A CD2 1 
ATOM   2667 C CE1 . HIS A 1 421 ? 108.383 101.645 95.291  1.00 67.68  ? 421 HIS A CE1 1 
ATOM   2668 N NE2 . HIS A 1 421 ? 108.074 101.716 94.009  1.00 67.68  ? 421 HIS A NE2 1 
ATOM   2669 N N   . GLN A 1 422 ? 110.719 97.241  96.580  1.00 73.21  ? 422 GLN A N   1 
ATOM   2670 C CA  . GLN A 1 422 ? 111.672 97.624  97.608  1.00 73.21  ? 422 GLN A CA  1 
ATOM   2671 C C   . GLN A 1 422 ? 113.079 97.126  97.319  1.00 73.21  ? 422 GLN A C   1 
ATOM   2672 O O   . GLN A 1 422 ? 114.025 97.689  97.870  1.00 73.21  ? 422 GLN A O   1 
ATOM   2673 C CB  . GLN A 1 422 ? 111.210 97.146  98.977  1.00 73.21  ? 422 GLN A CB  1 
ATOM   2674 C CG  . GLN A 1 422 ? 110.007 97.890  99.489  1.00 73.21  ? 422 GLN A CG  1 
ATOM   2675 C CD  . GLN A 1 422 ? 110.288 99.357  99.696  1.00 73.21  ? 422 GLN A CD  1 
ATOM   2676 O OE1 . GLN A 1 422 ? 109.812 100.202 98.942  1.00 73.21  ? 422 GLN A OE1 1 
ATOM   2677 N NE2 . GLN A 1 422 ? 111.066 99.670  100.724 1.00 73.21  ? 422 GLN A NE2 1 
ATOM   2678 N N   . VAL A 1 423 ? 113.241 96.116  96.456  1.00 72.77  ? 423 VAL A N   1 
ATOM   2679 C CA  . VAL A 1 423 ? 114.566 95.792  95.928  1.00 72.77  ? 423 VAL A CA  1 
ATOM   2680 C C   . VAL A 1 423 ? 115.129 96.981  95.166  1.00 72.77  ? 423 VAL A C   1 
ATOM   2681 O O   . VAL A 1 423 ? 116.266 97.410  95.404  1.00 72.77  ? 423 VAL A O   1 
ATOM   2682 C CB  . VAL A 1 423 ? 114.519 94.527  95.049  1.00 72.77  ? 423 VAL A CB  1 
ATOM   2683 C CG1 . VAL A 1 423 ? 115.762 94.420  94.191  1.00 72.77  ? 423 VAL A CG1 1 
ATOM   2684 C CG2 . VAL A 1 423 ? 114.463 93.290  95.912  1.00 72.77  ? 423 VAL A CG2 1 
ATOM   2685 N N   . THR A 1 424 ? 114.324 97.566  94.275  1.00 69.23  ? 424 THR A N   1 
ATOM   2686 C CA  . THR A 1 424 ? 114.858 98.708  93.537  1.00 69.23  ? 424 THR A CA  1 
ATOM   2687 C C   . THR A 1 424 ? 114.920 99.981  94.389  1.00 69.23  ? 424 THR A C   1 
ATOM   2688 O O   . THR A 1 424 ? 115.821 100.800 94.169  1.00 69.23  ? 424 THR A O   1 
ATOM   2689 C CB  . THR A 1 424 ? 114.096 98.925  92.224  1.00 69.23  ? 424 THR A CB  1 
ATOM   2690 O OG1 . THR A 1 424 ? 114.728 99.968  91.479  1.00 69.23  ? 424 THR A OG1 1 
ATOM   2691 C CG2 . THR A 1 424 ? 112.672 99.293  92.439  1.00 69.23  ? 424 THR A CG2 1 
ATOM   2692 N N   . VAL A 1 425 ? 114.057 100.122 95.410  1.00 70.24  ? 425 VAL A N   1 
ATOM   2693 C CA  . VAL A 1 425 ? 114.191 101.219 96.379  1.00 70.24  ? 425 VAL A CA  1 
ATOM   2694 C C   . VAL A 1 425 ? 115.502 101.106 97.147  1.00 70.24  ? 425 VAL A C   1 
ATOM   2695 O O   . VAL A 1 425 ? 116.250 102.081 97.272  1.00 70.24  ? 425 VAL A O   1 
ATOM   2696 C CB  . VAL A 1 425 ? 112.989 101.254 97.345  1.00 70.24  ? 425 VAL A CB  1 
ATOM   2697 C CG1 . VAL A 1 425 ? 113.282 102.136 98.548  1.00 70.24  ? 425 VAL A CG1 1 
ATOM   2698 C CG2 . VAL A 1 425 ? 111.776 101.818 96.677  1.00 70.24  ? 425 VAL A CG2 1 
ATOM   2699 N N   . TYR A 1 426 ? 115.808 99.911  97.660  1.00 77.75  ? 426 TYR A N   1 
ATOM   2700 C CA  . TYR A 1 426 ? 117.000 99.733  98.480  1.00 77.75  ? 426 TYR A CA  1 
ATOM   2701 C C   . TYR A 1 426 ? 118.270 99.803  97.647  1.00 77.75  ? 426 TYR A C   1 
ATOM   2702 O O   . TYR A 1 426 ? 119.288 100.308 98.131  1.00 77.75  ? 426 TYR A O   1 
ATOM   2703 C CB  . TYR A 1 426 ? 116.921 98.407  99.235  1.00 77.75  ? 426 TYR A CB  1 
ATOM   2704 C CG  . TYR A 1 426 ? 115.849 98.368  100.306 1.00 77.75  ? 426 TYR A CG  1 
ATOM   2705 C CD1 . TYR A 1 426 ? 115.335 99.539  100.854 1.00 77.75  ? 426 TYR A CD1 1 
ATOM   2706 C CD2 . TYR A 1 426 ? 115.327 97.156  100.744 1.00 77.75  ? 426 TYR A CD2 1 
ATOM   2707 C CE1 . TYR A 1 426 ? 114.349 99.502  101.822 1.00 77.75  ? 426 TYR A CE1 1 
ATOM   2708 C CE2 . TYR A 1 426 ? 114.339 97.110  101.707 1.00 77.75  ? 426 TYR A CE2 1 
ATOM   2709 C CZ  . TYR A 1 426 ? 113.854 98.285  102.243 1.00 77.75  ? 426 TYR A CZ  1 
ATOM   2710 O OH  . TYR A 1 426 ? 112.873 98.239  103.205 1.00 77.75  ? 426 TYR A OH  1 
ATOM   2711 N N   . SER A 1 427 ? 118.223 99.350  96.388  1.00 74.78  ? 427 SER A N   1 
ATOM   2712 C CA  . SER A 1 427 ? 119.379 99.505  95.510  1.00 74.78  ? 427 SER A CA  1 
ATOM   2713 C C   . SER A 1 427 ? 119.608 100.968 95.158  1.00 74.78  ? 427 SER A C   1 
ATOM   2714 O O   . SER A 1 427 ? 120.753 101.434 95.133  1.00 74.78  ? 427 SER A O   1 
ATOM   2715 C CB  . SER A 1 427 ? 119.198 98.678  94.242  1.00 74.78  ? 427 SER A CB  1 
ATOM   2716 O OG  . SER A 1 427 ? 118.176 99.226  93.433  1.00 74.78  ? 427 SER A OG  1 
ATOM   2717 N N   . MET A 1 428 ? 118.527 101.717 94.925  1.00 75.67  ? 428 MET A N   1 
ATOM   2718 C CA  . MET A 1 428 ? 118.637 103.148 94.663  1.00 75.67  ? 428 MET A CA  1 
ATOM   2719 C C   . MET A 1 428 ? 119.158 103.908 95.882  1.00 75.67  ? 428 MET A C   1 
ATOM   2720 O O   . MET A 1 428 ? 120.009 104.800 95.754  1.00 75.67  ? 428 MET A O   1 
ATOM   2721 C CB  . MET A 1 428 ? 117.267 103.654 94.225  1.00 75.67  ? 428 MET A CB  1 
ATOM   2722 C CG  . MET A 1 428 ? 117.199 105.088 93.851  1.00 75.67  ? 428 MET A CG  1 
ATOM   2723 S SD  . MET A 1 428 ? 115.607 105.495 93.130  1.00 75.67  ? 428 MET A SD  1 
ATOM   2724 C CE  . MET A 1 428 ? 115.736 104.642 91.564  1.00 75.67  ? 428 MET A CE  1 
ATOM   2725 N N   . TYR A 1 429 ? 118.695 103.530 97.074  1.00 78.23  ? 429 TYR A N   1 
ATOM   2726 C CA  . TYR A 1 429 ? 119.129 104.182 98.304  1.00 78.23  ? 429 TYR A CA  1 
ATOM   2727 C C   . TYR A 1 429 ? 120.590 103.880 98.609  1.00 78.23  ? 429 TYR A C   1 
ATOM   2728 O O   . TYR A 1 429 ? 121.344 104.783 98.991  1.00 78.23  ? 429 TYR A O   1 
ATOM   2729 C CB  . TYR A 1 429 ? 118.240 103.739 99.464  1.00 78.23  ? 429 TYR A CB  1 
ATOM   2730 C CG  . TYR A 1 429 ? 118.539 104.409 100.782 1.00 78.23  ? 429 TYR A CG  1 
ATOM   2731 C CD1 . TYR A 1 429 ? 118.100 105.698 101.039 1.00 78.23  ? 429 TYR A CD1 1 
ATOM   2732 C CD2 . TYR A 1 429 ? 119.252 103.747 101.774 1.00 78.23  ? 429 TYR A CD2 1 
ATOM   2733 C CE1 . TYR A 1 429 ? 118.363 106.313 102.246 1.00 78.23  ? 429 TYR A CE1 1 
ATOM   2734 C CE2 . TYR A 1 429 ? 119.525 104.355 102.982 1.00 78.23  ? 429 TYR A CE2 1 
ATOM   2735 C CZ  . TYR A 1 429 ? 119.078 105.639 103.211 1.00 78.23  ? 429 TYR A CZ  1 
ATOM   2736 O OH  . TYR A 1 429 ? 119.343 106.252 104.413 1.00 78.23  ? 429 TYR A OH  1 
ATOM   2737 N N   . VAL A 1 430 ? 121.018 102.626 98.429  1.00 78.15  ? 430 VAL A N   1 
ATOM   2738 C CA  . VAL A 1 430 ? 122.415 102.305 98.683  1.00 78.15  ? 430 VAL A CA  1 
ATOM   2739 C C   . VAL A 1 430 ? 123.304 102.883 97.589  1.00 78.15  ? 430 VAL A C   1 
ATOM   2740 O O   . VAL A 1 430 ? 124.474 103.175 97.846  1.00 78.15  ? 430 VAL A O   1 
ATOM   2741 C CB  . VAL A 1 430 ? 122.612 100.782 98.856  1.00 78.15  ? 430 VAL A CB  1 
ATOM   2742 C CG1 . VAL A 1 430 ? 122.550 100.039 97.535  1.00 78.15  ? 430 VAL A CG1 1 
ATOM   2743 C CG2 . VAL A 1 430 ? 123.902 100.476 99.604  1.00 78.15  ? 430 VAL A CG2 1 
ATOM   2744 N N   . SER A 1 431 ? 122.756 103.147 96.396  1.00 81.20  ? 431 SER A N   1 
ATOM   2745 C CA  . SER A 1 431 ? 123.521 103.865 95.384  1.00 81.20  ? 431 SER A CA  1 
ATOM   2746 C C   . SER A 1 431 ? 123.734 105.320 95.776  1.00 81.20  ? 431 SER A C   1 
ATOM   2747 O O   . SER A 1 431 ? 124.821 105.868 95.561  1.00 81.20  ? 431 SER A O   1 
ATOM   2748 C CB  . SER A 1 431 ? 122.817 103.797 94.038  1.00 81.20  ? 431 SER A CB  1 
ATOM   2749 O OG  . SER A 1 431 ? 123.594 104.458 93.061  1.00 81.20  ? 431 SER A OG  1 
ATOM   2750 N N   . ILE A 1 432 ? 122.707 105.960 96.343  1.00 80.63  ? 432 ILE A N   1 
ATOM   2751 C CA  . ILE A 1 432 ? 122.866 107.336 96.814  1.00 80.63  ? 432 ILE A CA  1 
ATOM   2752 C C   . ILE A 1 432 ? 123.851 107.401 97.980  1.00 80.63  ? 432 ILE A C   1 
ATOM   2753 O O   . ILE A 1 432 ? 124.713 108.289 98.027  1.00 80.63  ? 432 ILE A O   1 
ATOM   2754 C CB  . ILE A 1 432 ? 121.498 107.944 97.176  1.00 80.63  ? 432 ILE A CB  1 
ATOM   2755 C CG1 . ILE A 1 432 ? 120.619 108.028 95.934  1.00 80.63  ? 432 ILE A CG1 1 
ATOM   2756 C CG2 . ILE A 1 432 ? 121.645 109.332 97.781  1.00 80.63  ? 432 ILE A CG2 1 
ATOM   2757 C CD1 . ILE A 1 432 ? 121.195 108.902 94.849  1.00 80.63  ? 432 ILE A CD1 1 
ATOM   2758 N N   . MET A 1 433 ? 123.779 106.435 98.908  1.00 83.28  ? 433 MET A N   1 
ATOM   2759 C CA  . MET A 1 433 ? 124.720 106.412 100.030 1.00 83.28  ? 433 MET A CA  1 
ATOM   2760 C C   . MET A 1 433 ? 126.147 106.143 99.558  1.00 83.28  ? 433 MET A C   1 
ATOM   2761 O O   . MET A 1 433 ? 127.102 106.729 100.083 1.00 83.28  ? 433 MET A O   1 
ATOM   2762 C CB  . MET A 1 433 ? 124.316 105.359 101.062 1.00 83.28  ? 433 MET A CB  1 
ATOM   2763 C CG  . MET A 1 433 ? 122.952 105.541 101.707 1.00 83.28  ? 433 MET A CG  1 
ATOM   2764 S SD  . MET A 1 433 ? 122.660 107.134 102.482 1.00 83.28  ? 433 MET A SD  1 
ATOM   2765 C CE  . MET A 1 433 ? 121.507 107.845 101.310 1.00 83.28  ? 433 MET A CE  1 
ATOM   2766 N N   . ALA A 1 434 ? 126.305 105.285 98.548  1.00 88.64  ? 434 ALA A N   1 
ATOM   2767 C CA  . ALA A 1 434 ? 127.627 105.003 98.007  1.00 88.64  ? 434 ALA A CA  1 
ATOM   2768 C C   . ALA A 1 434 ? 128.182 106.197 97.245  1.00 88.64  ? 434 ALA A C   1 
ATOM   2769 O O   . ALA A 1 434 ? 129.390 106.453 97.286  1.00 88.64  ? 434 ALA A O   1 
ATOM   2770 C CB  . ALA A 1 434 ? 127.565 103.774 97.106  1.00 88.64  ? 434 ALA A CB  1 
ATOM   2771 N N   . PHE A 1 435 ? 127.314 106.947 96.557  1.00 90.33  ? 435 PHE A N   1 
ATOM   2772 C CA  . PHE A 1 435 ? 127.748 108.178 95.905  1.00 90.33  ? 435 PHE A CA  1 
ATOM   2773 C C   . PHE A 1 435 ? 128.187 109.217 96.924  1.00 90.33  ? 435 PHE A C   1 
ATOM   2774 O O   . PHE A 1 435 ? 129.163 109.943 96.697  1.00 90.33  ? 435 PHE A O   1 
ATOM   2775 C CB  . PHE A 1 435 ? 126.630 108.742 95.035  1.00 90.33  ? 435 PHE A CB  1 
ATOM   2776 C CG  . PHE A 1 435 ? 126.981 110.038 94.371  1.00 90.33  ? 435 PHE A CG  1 
ATOM   2777 C CD1 . PHE A 1 435 ? 127.843 110.063 93.293  1.00 90.33  ? 435 PHE A CD1 1 
ATOM   2778 C CD2 . PHE A 1 435 ? 126.448 111.234 94.825  1.00 90.33  ? 435 PHE A CD2 1 
ATOM   2779 C CE1 . PHE A 1 435 ? 128.163 111.252 92.676  1.00 90.33  ? 435 PHE A CE1 1 
ATOM   2780 C CE2 . PHE A 1 435 ? 126.773 112.429 94.217  1.00 90.33  ? 435 PHE A CE2 1 
ATOM   2781 C CZ  . PHE A 1 435 ? 127.629 112.437 93.139  1.00 90.33  ? 435 PHE A CZ  1 
ATOM   2782 N N   . ASN A 1 436 ? 127.490 109.293 98.058  1.00 91.71  ? 436 ASN A N   1 
ATOM   2783 C CA  . ASN A 1 436 ? 127.872 110.272 99.067  1.00 91.71  ? 436 ASN A CA  1 
ATOM   2784 C C   . ASN A 1 436 ? 129.176 109.877 99.746  1.00 91.71  ? 436 ASN A C   1 
ATOM   2785 O O   . ASN A 1 436 ? 130.014 110.738 100.034 1.00 91.71  ? 436 ASN A O   1 
ATOM   2786 C CB  . ASN A 1 436 ? 126.753 110.439 100.086 1.00 91.71  ? 436 ASN A CB  1 
ATOM   2787 C CG  . ASN A 1 436 ? 125.468 110.881 99.448  1.00 91.71  ? 436 ASN A CG  1 
ATOM   2788 O OD1 . ASN A 1 436 ? 125.478 111.556 98.425  1.00 91.71  ? 436 ASN A OD1 1 
ATOM   2789 N ND2 . ASN A 1 436 ? 124.347 110.505 100.047 1.00 91.71  ? 436 ASN A ND2 1 
ATOM   2790 N N   . ALA A 1 437 ? 129.383 108.576 99.969  1.00 92.33  ? 437 ALA A N   1 
ATOM   2791 C CA  . ALA A 1 437 ? 130.661 108.111 100.501 1.00 92.33  ? 437 ALA A CA  1 
ATOM   2792 C C   . ALA A 1 437 ? 131.790 108.277 99.490  1.00 92.33  ? 437 ALA A C   1 
ATOM   2793 O O   . ALA A 1 437 ? 132.949 108.450 99.882  1.00 92.33  ? 437 ALA A O   1 
ATOM   2794 C CB  . ALA A 1 437 ? 130.551 106.651 100.937 1.00 92.33  ? 437 ALA A CB  1 
ATOM   2795 N N   . LYS A 1 438 ? 131.474 108.229 98.195  1.00 93.83  ? 438 LYS A N   1 
ATOM   2796 C CA  . LYS A 1 438 ? 132.484 108.456 97.168  1.00 93.83  ? 438 LYS A CA  1 
ATOM   2797 C C   . LYS A 1 438 ? 132.885 109.925 97.096  1.00 93.83  ? 438 LYS A C   1 
ATOM   2798 O O   . LYS A 1 438 ? 134.070 110.244 96.949  1.00 93.83  ? 438 LYS A O   1 
ATOM   2799 C CB  . LYS A 1 438 ? 131.955 107.972 95.817  1.00 93.83  ? 438 LYS A CB  1 
ATOM   2800 C CG  . LYS A 1 438 ? 132.876 108.206 94.631  1.00 93.83  ? 438 LYS A CG  1 
ATOM   2801 C CD  . LYS A 1 438 ? 134.123 107.350 94.704  1.00 93.83  ? 438 LYS A CD  1 
ATOM   2802 C CE  . LYS A 1 438 ? 134.923 107.449 93.415  1.00 93.83  ? 438 LYS A CE  1 
ATOM   2803 N NZ  . LYS A 1 438 ? 135.464 108.817 93.193  1.00 93.83  ? 438 LYS A NZ  1 
ATOM   2804 N N   . VAL A 1 439 ? 131.918 110.832 97.212  1.00 96.94  ? 439 VAL A N   1 
ATOM   2805 C CA  . VAL A 1 439 ? 132.203 112.244 96.981  1.00 96.94  ? 439 VAL A CA  1 
ATOM   2806 C C   . VAL A 1 439 ? 132.670 112.974 98.245  1.00 96.94  ? 439 VAL A C   1 
ATOM   2807 O O   . VAL A 1 439 ? 133.551 113.839 98.158  1.00 96.94  ? 439 VAL A O   1 
ATOM   2808 C CB  . VAL A 1 439 ? 130.963 112.905 96.346  1.00 96.94  ? 439 VAL A CB  1 
ATOM   2809 C CG1 . VAL A 1 439 ? 131.120 114.413 96.179  1.00 96.94  ? 439 VAL A CG1 1 
ATOM   2810 C CG2 . VAL A 1 439 ? 130.721 112.294 94.990  1.00 96.94  ? 439 VAL A CG2 1 
ATOM   2811 N N   . SER A 1 440 ? 132.154 112.608 99.424  1.00 104.95 ? 440 SER A N   1 
ATOM   2812 C CA  . SER A 1 440 ? 132.412 113.360 100.650 1.00 104.95 ? 440 SER A CA  1 
ATOM   2813 C C   . SER A 1 440 ? 133.872 113.261 101.081 1.00 104.95 ? 440 SER A C   1 
ATOM   2814 O O   . SER A 1 440 ? 134.369 112.174 101.390 1.00 104.95 ? 440 SER A O   1 
ATOM   2815 C CB  . SER A 1 440 ? 131.499 112.861 101.765 1.00 104.95 ? 440 SER A CB  1 
ATOM   2816 O OG  . SER A 1 440 ? 131.826 111.533 102.131 1.00 104.95 ? 440 SER A OG  1 
ATOM   2817 N N   . ASP A 1 441 ? 134.549 114.407 101.095 1.00 115.25 ? 441 ASP A N   1 
ATOM   2818 C CA  . ASP A 1 441 ? 135.938 114.469 101.508 1.00 115.25 ? 441 ASP A CA  1 
ATOM   2819 C C   . ASP A 1 441 ? 136.046 114.280 103.021 1.00 115.25 ? 441 ASP A C   1 
ATOM   2820 O O   . ASP A 1 441 ? 135.123 114.626 103.762 1.00 115.25 ? 441 ASP A O   1 
ATOM   2821 C CB  . ASP A 1 441 ? 136.544 115.810 101.100 1.00 115.25 ? 441 ASP A CB  1 
ATOM   2822 C CG  . ASP A 1 441 ? 136.686 115.948 99.599  1.00 115.25 ? 441 ASP A CG  1 
ATOM   2823 O OD1 . ASP A 1 441 ? 136.849 114.911 98.922  1.00 115.25 ? 441 ASP A OD1 1 
ATOM   2824 O OD2 . ASP A 1 441 ? 136.636 117.090 99.097  1.00 115.25 ? 441 ASP A OD2 1 
ATOM   2825 N N   . PRO A 1 442 ? 137.167 113.731 103.508 1.00 118.62 ? 442 PRO A N   1 
ATOM   2826 C CA  . PRO A 1 442 ? 137.306 113.499 104.958 1.00 118.62 ? 442 PRO A CA  1 
ATOM   2827 C C   . PRO A 1 442 ? 137.465 114.764 105.793 1.00 118.62 ? 442 PRO A C   1 
ATOM   2828 O O   . PRO A 1 442 ? 137.519 114.657 107.026 1.00 118.62 ? 442 PRO A O   1 
ATOM   2829 C CB  . PRO A 1 442 ? 138.565 112.625 105.054 1.00 118.62 ? 442 PRO A CB  1 
ATOM   2830 C CG  . PRO A 1 442 ? 138.700 111.998 103.710 1.00 118.62 ? 442 PRO A CG  1 
ATOM   2831 C CD  . PRO A 1 442 ? 138.222 113.038 102.747 1.00 118.62 ? 442 PRO A CD  1 
ATOM   2832 N N   . LEU A 1 443 ? 137.552 115.946 105.179 1.00 116.35 ? 443 LEU A N   1 
ATOM   2833 C CA  . LEU A 1 443 ? 137.656 117.178 105.951 1.00 116.35 ? 443 LEU A CA  1 
ATOM   2834 C C   . LEU A 1 443 ? 136.327 117.520 106.614 1.00 116.35 ? 443 LEU A C   1 
ATOM   2835 O O   . LEU A 1 443 ? 136.221 117.550 107.845 1.00 116.35 ? 443 LEU A O   1 
ATOM   2836 C CB  . LEU A 1 443 ? 138.116 118.322 105.044 1.00 116.35 ? 443 LEU A CB  1 
ATOM   2837 C CG  . LEU A 1 443 ? 139.515 118.208 104.432 1.00 116.35 ? 443 LEU A CG  1 
ATOM   2838 C CD1 . LEU A 1 443 ? 139.759 119.335 103.440 1.00 116.35 ? 443 LEU A CD1 1 
ATOM   2839 C CD2 . LEU A 1 443 ? 140.582 118.204 105.515 1.00 116.35 ? 443 LEU A CD2 1 
ATOM   2840 N N   . ILE A 1 444 ? 135.296 117.778 105.808 1.00 114.97 ? 444 ILE A N   1 
ATOM   2841 C CA  . ILE A 1 444 ? 133.985 118.160 106.322 1.00 114.97 ? 444 ILE A CA  1 
ATOM   2842 C C   . ILE A 1 444 ? 133.020 117.059 105.884 1.00 114.97 ? 444 ILE A C   1 
ATOM   2843 O O   . ILE A 1 444 ? 131.863 117.319 105.524 1.00 114.97 ? 444 ILE A O   1 
ATOM   2844 C CB  . ILE A 1 444 ? 133.556 119.556 105.820 1.00 114.97 ? 444 ILE A CB  1 
ATOM   2845 C CG1 . ILE A 1 444 ? 134.734 120.539 105.832 1.00 114.97 ? 444 ILE A CG1 1 
ATOM   2846 C CG2 . ILE A 1 444 ? 132.513 120.176 106.758 1.00 114.97 ? 444 ILE A CG2 1 
ATOM   2847 C CD1 . ILE A 1 444 ? 135.312 120.860 107.215 1.00 114.97 ? 444 ILE A CD1 1 
ATOM   2848 N N   . GLY A 1 445 ? 133.521 115.819 105.859 1.00 112.09 ? 445 GLY A N   1 
ATOM   2849 C CA  . GLY A 1 445 ? 132.706 114.699 105.413 1.00 112.09 ? 445 GLY A CA  1 
ATOM   2850 C C   . GLY A 1 445 ? 131.526 114.410 106.319 1.00 112.09 ? 445 GLY A C   1 
ATOM   2851 O O   . GLY A 1 445 ? 130.436 114.091 105.840 1.00 112.09 ? 445 GLY A O   1 
ATOM   2852 N N   . GLY A 1 446 ? 131.710 114.573 107.633 1.00 110.97 ? 446 GLY A N   1 
ATOM   2853 C CA  . GLY A 1 446 ? 130.648 114.311 108.593 1.00 110.97 ? 446 GLY A CA  1 
ATOM   2854 C C   . GLY A 1 446 ? 129.473 115.265 108.509 1.00 110.97 ? 446 GLY A C   1 
ATOM   2855 O O   . GLY A 1 446 ? 128.422 114.991 109.098 1.00 110.97 ? 446 GLY A O   1 
ATOM   2856 N N   . THR A 1 447 ? 129.629 116.385 107.804 1.00 107.54 ? 447 THR A N   1 
ATOM   2857 C CA  . THR A 1 447 ? 128.538 117.295 107.487 1.00 107.54 ? 447 THR A CA  1 
ATOM   2858 C C   . THR A 1 447 ? 128.060 117.141 106.048 1.00 107.54 ? 447 THR A C   1 
ATOM   2859 O O   . THR A 1 447 ? 126.853 117.153 105.794 1.00 107.54 ? 447 THR A O   1 
ATOM   2860 C CB  . THR A 1 447 ? 128.979 118.744 107.737 1.00 107.54 ? 447 THR A CB  1 
ATOM   2861 O OG1 . THR A 1 447 ? 129.452 118.870 109.083 1.00 107.54 ? 447 THR A OG1 1 
ATOM   2862 C CG2 . THR A 1 447 ? 127.824 119.716 107.543 1.00 107.54 ? 447 THR A CG2 1 
ATOM   2863 N N   . TYR A 1 448 ? 128.988 116.938 105.107 1.00 103.51 ? 448 TYR A N   1 
ATOM   2864 C CA  . TYR A 1 448 ? 128.640 116.900 103.689 1.00 103.51 ? 448 TYR A CA  1 
ATOM   2865 C C   . TYR A 1 448 ? 127.894 115.617 103.324 1.00 103.51 ? 448 TYR A C   1 
ATOM   2866 O O   . TYR A 1 448 ? 126.992 115.640 102.470 1.00 103.51 ? 448 TYR A O   1 
ATOM   2867 C CB  . TYR A 1 448 ? 129.923 117.054 102.873 1.00 103.51 ? 448 TYR A CB  1 
ATOM   2868 C CG  . TYR A 1 448 ? 129.762 117.118 101.379 1.00 103.51 ? 448 TYR A CG  1 
ATOM   2869 C CD1 . TYR A 1 448 ? 129.328 118.274 100.751 1.00 103.51 ? 448 TYR A CD1 1 
ATOM   2870 C CD2 . TYR A 1 448 ? 130.076 116.027 100.593 1.00 103.51 ? 448 TYR A CD2 1 
ATOM   2871 C CE1 . TYR A 1 448 ? 129.200 118.327 99.375  1.00 103.51 ? 448 TYR A CE1 1 
ATOM   2872 C CE2 . TYR A 1 448 ? 129.958 116.070 99.227  1.00 103.51 ? 448 TYR A CE2 1 
ATOM   2873 C CZ  . TYR A 1 448 ? 129.513 117.221 98.620  1.00 103.51 ? 448 TYR A CZ  1 
ATOM   2874 O OH  . TYR A 1 448 ? 129.389 117.261 97.251  1.00 103.51 ? 448 TYR A OH  1 
ATOM   2875 N N   . MET A 1 449 ? 128.258 114.500 103.970 1.00 98.88  ? 449 MET A N   1 
ATOM   2876 C CA  . MET A 1 449 ? 127.553 113.226 103.848 1.00 98.88  ? 449 MET A CA  1 
ATOM   2877 C C   . MET A 1 449 ? 126.072 113.375 104.165 1.00 98.88  ? 449 MET A C   1 
ATOM   2878 O O   . MET A 1 449 ? 125.202 113.113 103.325 1.00 98.88  ? 449 MET A O   1 
ATOM   2879 C CB  . MET A 1 449 ? 128.187 112.217 104.810 1.00 98.88  ? 449 MET A CB  1 
ATOM   2880 C CG  . MET A 1 449 ? 127.600 110.817 104.790 1.00 98.88  ? 449 MET A CG  1 
ATOM   2881 S SD  . MET A 1 449 ? 128.125 109.838 103.385 1.00 98.88  ? 449 MET A SD  1 
ATOM   2882 C CE  . MET A 1 449 ? 129.808 109.487 103.883 1.00 98.88  ? 449 MET A CE  1 
ATOM   2883 N N   . THR A 1 450 ? 125.774 113.831 105.379 1.00 92.67  ? 450 THR A N   1 
ATOM   2884 C CA  . THR A 1 450 ? 124.389 114.000 105.783 1.00 92.67  ? 450 THR A CA  1 
ATOM   2885 C C   . THR A 1 450 ? 123.717 115.194 105.114 1.00 92.67  ? 450 THR A C   1 
ATOM   2886 O O   . THR A 1 450 ? 122.488 115.234 105.076 1.00 92.67  ? 450 THR A O   1 
ATOM   2887 C CB  . THR A 1 450 ? 124.305 114.077 107.311 1.00 92.67  ? 450 THR A CB  1 
ATOM   2888 O OG1 . THR A 1 450 ? 122.974 114.419 107.718 1.00 92.67  ? 450 THR A OG1 1 
ATOM   2889 C CG2 . THR A 1 450 ? 125.329 115.040 107.880 1.00 92.67  ? 450 THR A CG2 1 
ATOM   2890 N N   . LEU A 1 451 ? 124.474 116.123 104.517 1.00 87.62  ? 451 LEU A N   1 
ATOM   2891 C CA  . LEU A 1 451 ? 123.846 117.138 103.669 1.00 87.62  ? 451 LEU A CA  1 
ATOM   2892 C C   . LEU A 1 451 ? 123.297 116.528 102.391 1.00 87.62  ? 451 LEU A C   1 
ATOM   2893 O O   . LEU A 1 451 ? 122.166 116.828 101.985 1.00 87.62  ? 451 LEU A O   1 
ATOM   2894 C CB  . LEU A 1 451 ? 124.833 118.254 103.335 1.00 87.62  ? 451 LEU A CB  1 
ATOM   2895 C CG  . LEU A 1 451 ? 124.271 119.302 102.366 1.00 87.62  ? 451 LEU A CG  1 
ATOM   2896 C CD1 . LEU A 1 451 ? 123.044 120.005 102.920 1.00 87.62  ? 451 LEU A CD1 1 
ATOM   2897 C CD2 . LEU A 1 451 ? 125.318 120.310 102.018 1.00 87.62  ? 451 LEU A CD2 1 
ATOM   2898 N N   . LEU A 1 452 ? 124.084 115.677 101.735 1.00 87.62  ? 452 LEU A N   1 
ATOM   2899 C CA  . LEU A 1 452 ? 123.569 115.028 100.535 1.00 87.62  ? 452 LEU A CA  1 
ATOM   2900 C C   . LEU A 1 452 ? 122.475 114.020 100.866 1.00 87.62  ? 452 LEU A C   1 
ATOM   2901 O O   . LEU A 1 452 ? 121.540 113.844 100.074 1.00 87.62  ? 452 LEU A O   1 
ATOM   2902 C CB  . LEU A 1 452 ? 124.699 114.372 99.759  1.00 87.62  ? 452 LEU A CB  1 
ATOM   2903 C CG  . LEU A 1 452 ? 125.698 115.357 99.165  1.00 87.62  ? 452 LEU A CG  1 
ATOM   2904 C CD1 . LEU A 1 452 ? 126.783 114.618 98.417  1.00 87.62  ? 452 LEU A CD1 1 
ATOM   2905 C CD2 . LEU A 1 452 ? 124.983 116.332 98.264  1.00 87.62  ? 452 LEU A CD2 1 
ATOM   2906 N N   . ASN A 1 453 ? 122.545 113.398 102.048 1.00 87.29  ? 453 ASN A N   1 
ATOM   2907 C CA  . ASN A 1 453 ? 121.446 112.553 102.508 1.00 87.29  ? 453 ASN A CA  1 
ATOM   2908 C C   . ASN A 1 453 ? 120.180 113.372 102.745 1.00 87.29  ? 453 ASN A C   1 
ATOM   2909 O O   . ASN A 1 453 ? 119.078 112.949 102.370 1.00 87.29  ? 453 ASN A O   1 
ATOM   2910 C CB  . ASN A 1 453 ? 121.845 111.824 103.788 1.00 87.29  ? 453 ASN A CB  1 
ATOM   2911 C CG  . ASN A 1 453 ? 123.039 110.926 103.594 1.00 87.29  ? 453 ASN A CG  1 
ATOM   2912 O OD1 . ASN A 1 453 ? 123.226 110.348 102.530 1.00 87.29  ? 453 ASN A OD1 1 
ATOM   2913 N ND2 . ASN A 1 453 ? 123.856 110.797 104.631 1.00 87.29  ? 453 ASN A ND2 1 
ATOM   2914 N N   . THR A 1 454 ? 120.329 114.555 103.351 1.00 80.83  ? 454 THR A N   1 
ATOM   2915 C CA  . THR A 1 454 ? 119.211 115.460 103.593 1.00 80.83  ? 454 THR A CA  1 
ATOM   2916 C C   . THR A 1 454 ? 118.577 115.925 102.293 1.00 80.83  ? 454 THR A C   1 
ATOM   2917 O O   . THR A 1 454 ? 117.349 115.951 102.168 1.00 80.83  ? 454 THR A O   1 
ATOM   2918 C CB  . THR A 1 454 ? 119.704 116.656 104.408 1.00 80.83  ? 454 THR A CB  1 
ATOM   2919 O OG1 . THR A 1 454 ? 120.138 116.208 105.697 1.00 80.83  ? 454 THR A OG1 1 
ATOM   2920 C CG2 . THR A 1 454 ? 118.632 117.716 104.570 1.00 80.83  ? 454 THR A CG2 1 
ATOM   2921 N N   . VAL A 1 455 ? 119.394 116.257 101.298 1.00 75.80  ? 455 VAL A N   1 
ATOM   2922 C CA  . VAL A 1 455 ? 118.814 116.788 100.073 1.00 75.80  ? 455 VAL A CA  1 
ATOM   2923 C C   . VAL A 1 455 ? 118.218 115.666 99.216  1.00 75.80  ? 455 VAL A C   1 
ATOM   2924 O O   . VAL A 1 455 ? 117.211 115.882 98.530  1.00 75.80  ? 455 VAL A O   1 
ATOM   2925 C CB  . VAL A 1 455 ? 119.851 117.643 99.321  1.00 75.80  ? 455 VAL A CB  1 
ATOM   2926 C CG1 . VAL A 1 455 ? 120.920 116.811 98.641  1.00 75.80  ? 455 VAL A CG1 1 
ATOM   2927 C CG2 . VAL A 1 455 ? 119.175 118.545 98.354  1.00 75.80  ? 455 VAL A CG2 1 
ATOM   2928 N N   . SER A 1 456 ? 118.753 114.439 99.306  1.00 74.96  ? 456 SER A N   1 
ATOM   2929 C CA  . SER A 1 456 ? 118.122 113.312 98.626  1.00 74.96  ? 456 SER A CA  1 
ATOM   2930 C C   . SER A 1 456 ? 116.795 112.951 99.277  1.00 74.96  ? 456 SER A C   1 
ATOM   2931 O O   . SER A 1 456 ? 115.820 112.634 98.585  1.00 74.96  ? 456 SER A O   1 
ATOM   2932 C CB  . SER A 1 456 ? 119.059 112.108 98.626  1.00 74.96  ? 456 SER A CB  1 
ATOM   2933 O OG  . SER A 1 456 ? 118.437 110.986 98.030  1.00 74.96  ? 456 SER A OG  1 
ATOM   2934 N N   . ASN A 1 457 ? 116.718 113.037 100.603 1.00 75.13  ? 457 ASN A N   1 
ATOM   2935 C CA  . ASN A 1 457 ? 115.459 112.736 101.266 1.00 75.13  ? 457 ASN A CA  1 
ATOM   2936 C C   . ASN A 1 457 ? 114.436 113.857 101.087 1.00 75.13  ? 457 ASN A C   1 
ATOM   2937 O O   . ASN A 1 457 ? 113.233 113.582 101.040 1.00 75.13  ? 457 ASN A O   1 
ATOM   2938 C CB  . ASN A 1 457 ? 115.717 112.448 102.741 1.00 75.13  ? 457 ASN A CB  1 
ATOM   2939 C CG  . ASN A 1 457 ? 116.551 111.200 102.947 1.00 75.13  ? 457 ASN A CG  1 
ATOM   2940 O OD1 . ASN A 1 457 ? 116.375 110.201 102.252 1.00 75.13  ? 457 ASN A OD1 1 
ATOM   2941 N ND2 . ASN A 1 457 ? 117.472 111.255 103.899 1.00 75.13  ? 457 ASN A ND2 1 
ATOM   2942 N N   . LEU A 1 458 ? 114.888 115.110 100.952 1.00 71.04  ? 458 LEU A N   1 
ATOM   2943 C CA  . LEU A 1 458 ? 113.980 116.194 100.586 1.00 71.04  ? 458 LEU A CA  1 
ATOM   2944 C C   . LEU A 1 458 ? 113.427 115.977 99.188  1.00 71.04  ? 458 LEU A C   1 
ATOM   2945 O O   . LEU A 1 458 ? 112.232 116.178 98.949  1.00 71.04  ? 458 LEU A O   1 
ATOM   2946 C CB  . LEU A 1 458 ? 114.696 117.547 100.668 1.00 71.04  ? 458 LEU A CB  1 
ATOM   2947 C CG  . LEU A 1 458 ? 113.949 118.895 100.609 1.00 71.04  ? 458 LEU A CG  1 
ATOM   2948 C CD1 . LEU A 1 458 ? 114.769 119.953 101.320 1.00 71.04  ? 458 LEU A CD1 1 
ATOM   2949 C CD2 . LEU A 1 458 ? 113.634 119.398 99.202  1.00 71.04  ? 458 LEU A CD2 1 
ATOM   2950 N N   . GLY A 1 459 ? 114.286 115.571 98.248  1.00 75.39  ? 459 GLY A N   1 
ATOM   2951 C CA  . GLY A 1 459 ? 113.828 115.248 96.909  1.00 75.39  ? 459 GLY A CA  1 
ATOM   2952 C C   . GLY A 1 459 ? 112.974 114.002 96.839  1.00 75.39  ? 459 GLY A C   1 
ATOM   2953 O O   . GLY A 1 459 ? 112.283 113.792 95.839  1.00 75.39  ? 459 GLY A O   1 
ATOM   2954 N N   . GLY A 1 460 ? 113.033 113.154 97.865  1.00 72.32  ? 460 GLY A N   1 
ATOM   2955 C CA  . GLY A 1 460 ? 112.106 112.043 97.946  1.00 72.32  ? 460 GLY A CA  1 
ATOM   2956 C C   . GLY A 1 460 ? 110.773 112.397 98.566  1.00 72.32  ? 460 GLY A C   1 
ATOM   2957 O O   . GLY A 1 460 ? 109.746 111.825 98.189  1.00 72.32  ? 460 GLY A O   1 
ATOM   2958 N N   . ASN A 1 461 ? 110.760 113.332 99.515  1.00 71.84  ? 461 ASN A N   1 
ATOM   2959 C CA  . ASN A 1 461 ? 109.543 113.626 100.257 1.00 71.84  ? 461 ASN A CA  1 
ATOM   2960 C C   . ASN A 1 461 ? 108.761 114.830 99.747  1.00 71.84  ? 461 ASN A C   1 
ATOM   2961 O O   . ASN A 1 461 ? 107.600 114.985 100.137 1.00 71.84  ? 461 ASN A O   1 
ATOM   2962 C CB  . ASN A 1 461 ? 109.858 113.828 101.741 1.00 71.84  ? 461 ASN A CB  1 
ATOM   2963 C CG  . ASN A 1 461 ? 110.261 112.547 102.428 1.00 71.84  ? 461 ASN A CG  1 
ATOM   2964 O OD1 . ASN A 1 461 ? 111.380 112.413 102.916 1.00 71.84  ? 461 ASN A OD1 1 
ATOM   2965 N ND2 . ASN A 1 461 ? 109.344 111.588 102.468 1.00 71.84  ? 461 ASN A ND2 1 
ATOM   2966 N N   . TRP A 1 462 ? 109.342 115.697 98.908  1.00 66.51  ? 462 TRP A N   1 
ATOM   2967 C CA  . TRP A 1 462 ? 108.465 116.745 98.381  1.00 66.51  ? 462 TRP A CA  1 
ATOM   2968 C C   . TRP A 1 462 ? 107.526 116.286 97.254  1.00 66.51  ? 462 TRP A C   1 
ATOM   2969 O O   . TRP A 1 462 ? 106.377 116.758 97.238  1.00 66.51  ? 462 TRP A O   1 
ATOM   2970 C CB  . TRP A 1 462 ? 109.235 118.007 97.942  1.00 66.51  ? 462 TRP A CB  1 
ATOM   2971 C CG  . TRP A 1 462 ? 109.966 117.981 96.645  1.00 66.51  ? 462 TRP A CG  1 
ATOM   2972 C CD1 . TRP A 1 462 ? 111.269 117.665 96.443  1.00 66.51  ? 462 TRP A CD1 1 
ATOM   2973 C CD2 . TRP A 1 462 ? 109.424 118.279 95.354  1.00 66.51  ? 462 TRP A CD2 1 
ATOM   2974 N NE1 . TRP A 1 462 ? 111.578 117.746 95.109  1.00 66.51  ? 462 TRP A NE1 1 
ATOM   2975 C CE2 . TRP A 1 462 ? 110.457 118.119 94.420  1.00 66.51  ? 462 TRP A CE2 1 
ATOM   2976 C CE3 . TRP A 1 462 ? 108.161 118.660 94.899  1.00 66.51  ? 462 TRP A CE3 1 
ATOM   2977 C CZ2 . TRP A 1 462 ? 110.269 118.337 93.062  1.00 66.51  ? 462 TRP A CZ2 1 
ATOM   2978 C CZ3 . TRP A 1 462 ? 107.975 118.867 93.554  1.00 66.51  ? 462 TRP A CZ3 1 
ATOM   2979 C CH2 . TRP A 1 462 ? 109.022 118.708 92.650  1.00 66.51  ? 462 TRP A CH2 1 
ATOM   2980 N N   . PRO A 1 463 ? 107.892 115.401 96.304  1.00 62.26  ? 463 PRO A N   1 
ATOM   2981 C CA  . PRO A 1 463 ? 106.871 114.983 95.337  1.00 62.26  ? 463 PRO A CA  1 
ATOM   2982 C C   . PRO A 1 463 ? 105.854 114.028 95.918  1.00 62.26  ? 463 PRO A C   1 
ATOM   2983 O O   . PRO A 1 463 ? 104.818 113.829 95.289  1.00 62.26  ? 463 PRO A O   1 
ATOM   2984 C CB  . PRO A 1 463 ? 107.680 114.315 94.222  1.00 62.26  ? 463 PRO A CB  1 
ATOM   2985 C CG  . PRO A 1 463 ? 109.044 114.744 94.421  1.00 62.26  ? 463 PRO A CG  1 
ATOM   2986 C CD  . PRO A 1 463 ? 109.175 114.801 95.887  1.00 62.26  ? 463 PRO A CD  1 
ATOM   2987 N N   . SER A 1 464 ? 106.101 113.463 97.102  1.00 62.60  ? 464 SER A N   1 
ATOM   2988 C CA  . SER A 1 464 ? 105.045 112.797 97.860  1.00 62.60  ? 464 SER A CA  1 
ATOM   2989 C C   . SER A 1 464 ? 103.910 113.759 98.188  1.00 62.60  ? 464 SER A C   1 
ATOM   2990 O O   . SER A 1 464 ? 102.733 113.458 97.950  1.00 62.60  ? 464 SER A O   1 
ATOM   2991 C CB  . SER A 1 464 ? 105.633 112.204 99.138  1.00 62.60  ? 464 SER A CB  1 
ATOM   2992 O OG  . SER A 1 464 ? 104.620 111.706 99.988  1.00 62.60  ? 464 SER A OG  1 
ATOM   2993 N N   . THR A 1 465 ? 104.252 114.933 98.720  1.00 57.29  ? 465 THR A N   1 
ATOM   2994 C CA  . THR A 1 465 ? 103.240 115.924 99.063  1.00 57.29  ? 465 THR A CA  1 
ATOM   2995 C C   . THR A 1 465 ? 102.599 116.517 97.816  1.00 57.29  ? 465 THR A C   1 
ATOM   2996 O O   . THR A 1 465 ? 101.377 116.706 97.777  1.00 57.29  ? 465 THR A O   1 
ATOM   2997 C CB  . THR A 1 465 ? 103.863 117.017 99.925  1.00 57.29  ? 465 THR A CB  1 
ATOM   2998 O OG1 . THR A 1 465 ? 104.417 116.423 101.103 1.00 57.29  ? 465 THR A OG1 1 
ATOM   2999 C CG2 . THR A 1 465 ? 102.824 118.032 100.336 1.00 57.29  ? 465 THR A CG2 1 
ATOM   3000 N N   . VAL A 1 466 ? 103.396 116.785 96.777  1.00 53.37  ? 466 VAL A N   1 
ATOM   3001 C CA  . VAL A 1 466 ? 102.822 117.306 95.535  1.00 53.37  ? 466 VAL A CA  1 
ATOM   3002 C C   . VAL A 1 466 ? 101.933 116.264 94.860  1.00 53.37  ? 466 VAL A C   1 
ATOM   3003 O O   . VAL A 1 466 ? 100.876 116.602 94.309  1.00 53.37  ? 466 VAL A O   1 
ATOM   3004 C CB  . VAL A 1 466 ? 103.953 117.808 94.622  1.00 53.37  ? 466 VAL A CB  1 
ATOM   3005 C CG1 . VAL A 1 466 ? 103.439 118.218 93.258  1.00 53.37  ? 466 VAL A CG1 1 
ATOM   3006 C CG2 . VAL A 1 466 ? 104.620 118.988 95.276  1.00 53.37  ? 466 VAL A CG2 1 
ATOM   3007 N N   . ALA A 1 467 ? 102.278 114.982 94.989  1.00 58.15  ? 467 ALA A N   1 
ATOM   3008 C CA  . ALA A 1 467 ? 101.464 113.904 94.445  1.00 58.15  ? 467 ALA A CA  1 
ATOM   3009 C C   . ALA A 1 467 ? 100.132 113.791 95.174  1.00 58.15  ? 467 ALA A C   1 
ATOM   3010 O O   . ALA A 1 467 ? 99.068  113.753 94.541  1.00 58.15  ? 467 ALA A O   1 
ATOM   3011 C CB  . ALA A 1 467 ? 102.242 112.594 94.534  1.00 58.15  ? 467 ALA A CB  1 
ATOM   3012 N N   . LEU A 1 468 ? 100.171 113.752 96.509  1.00 56.74  ? 468 LEU A N   1 
ATOM   3013 C CA  . LEU A 1 468 ? 98.942  113.683 97.290  1.00 56.74  ? 468 LEU A CA  1 
ATOM   3014 C C   . LEU A 1 468 ? 98.095  114.943 97.167  1.00 56.74  ? 468 LEU A C   1 
ATOM   3015 O O   . LEU A 1 468 ? 96.877  114.871 97.345  1.00 56.74  ? 468 LEU A O   1 
ATOM   3016 C CB  . LEU A 1 468 ? 99.270  113.413 98.753  1.00 56.74  ? 468 LEU A CB  1 
ATOM   3017 C CG  . LEU A 1 468 ? 99.790  112.013 99.051  1.00 56.74  ? 468 LEU A CG  1 
ATOM   3018 C CD1 . LEU A 1 468 ? 100.295 111.935 100.472 1.00 56.74  ? 468 LEU A CD1 1 
ATOM   3019 C CD2 . LEU A 1 468 ? 98.671  111.032 98.848  1.00 56.74  ? 468 LEU A CD2 1 
ATOM   3020 N N   . TRP A 1 469 ? 98.698  116.089 96.852  1.00 60.28  ? 469 TRP A N   1 
ATOM   3021 C CA  . TRP A 1 469 ? 97.895  117.275 96.593  1.00 60.28  ? 469 TRP A CA  1 
ATOM   3022 C C   . TRP A 1 469 ? 97.273  117.241 95.208  1.00 60.28  ? 469 TRP A C   1 
ATOM   3023 O O   . TRP A 1 469 ? 96.165  117.750 95.024  1.00 60.28  ? 469 TRP A O   1 
ATOM   3024 C CB  . TRP A 1 469 ? 98.740  118.537 96.762  1.00 60.28  ? 469 TRP A CB  1 
ATOM   3025 C CG  . TRP A 1 469 ? 97.958  119.789 96.580  1.00 60.28  ? 469 TRP A CG  1 
ATOM   3026 C CD1 . TRP A 1 469 ? 96.957  120.247 97.378  1.00 60.28  ? 469 TRP A CD1 1 
ATOM   3027 C CD2 . TRP A 1 469 ? 98.095  120.742 95.520  1.00 60.28  ? 469 TRP A CD2 1 
ATOM   3028 N NE1 . TRP A 1 469 ? 96.464  121.431 96.888  1.00 60.28  ? 469 TRP A NE1 1 
ATOM   3029 C CE2 . TRP A 1 469 ? 97.146  121.756 95.746  1.00 60.28  ? 469 TRP A CE2 1 
ATOM   3030 C CE3 . TRP A 1 469 ? 98.931  120.837 94.404  1.00 60.28  ? 469 TRP A CE3 1 
ATOM   3031 C CZ2 . TRP A 1 469 ? 97.010  122.852 94.898  1.00 60.28  ? 469 TRP A CZ2 1 
ATOM   3032 C CZ3 . TRP A 1 469 ? 98.794  121.925 93.564  1.00 60.28  ? 469 TRP A CZ3 1 
ATOM   3033 C CH2 . TRP A 1 469 ? 97.840  122.918 93.815  1.00 60.28  ? 469 TRP A CH2 1 
ATOM   3034 N N   . LEU A 1 470 ? 97.954  116.647 94.233  1.00 64.53  ? 470 LEU A N   1 
ATOM   3035 C CA  . LEU A 1 470 ? 97.416  116.556 92.884  1.00 64.53  ? 470 LEU A CA  1 
ATOM   3036 C C   . LEU A 1 470 ? 96.564  115.317 92.652  1.00 64.53  ? 470 LEU A C   1 
ATOM   3037 O O   . LEU A 1 470 ? 96.178  115.072 91.505  1.00 64.53  ? 470 LEU A O   1 
ATOM   3038 C CB  . LEU A 1 470 ? 98.550  116.588 91.857  1.00 64.53  ? 470 LEU A CB  1 
ATOM   3039 C CG  . LEU A 1 470 ? 99.274  117.922 91.713  1.00 64.53  ? 470 LEU A CG  1 
ATOM   3040 C CD1 . LEU A 1 470 ? 100.444 117.785 90.760  1.00 64.53  ? 470 LEU A CD1 1 
ATOM   3041 C CD2 . LEU A 1 470 ? 98.312  118.988 91.234  1.00 64.53  ? 470 LEU A CD2 1 
ATOM   3042 N N   . VAL A 1 471 ? 96.311  114.504 93.683  1.00 65.57  ? 471 VAL A N   1 
ATOM   3043 C CA  . VAL A 1 471 ? 95.326  113.424 93.546  1.00 65.57  ? 471 VAL A CA  1 
ATOM   3044 C C   . VAL A 1 471 ? 93.946  113.992 93.223  1.00 65.57  ? 471 VAL A C   1 
ATOM   3045 O O   . VAL A 1 471 ? 93.330  113.641 92.211  1.00 65.57  ? 471 VAL A O   1 
ATOM   3046 C CB  . VAL A 1 471 ? 95.263  112.557 94.814  1.00 65.57  ? 471 VAL A CB  1 
ATOM   3047 C CG1 . VAL A 1 471 ? 94.135  111.558 94.686  1.00 65.57  ? 471 VAL A CG1 1 
ATOM   3048 C CG2 . VAL A 1 471 ? 96.537  111.819 95.029  1.00 65.57  ? 471 VAL A CG2 1 
ATOM   3049 N N   . ASP A 1 472 ? 93.446  114.879 94.081  1.00 70.07  ? 472 ASP A N   1 
ATOM   3050 C CA  . ASP A 1 472 ? 92.073  115.376 94.002  1.00 70.07  ? 472 ASP A CA  1 
ATOM   3051 C C   . ASP A 1 472 ? 91.706  116.239 92.788  1.00 70.07  ? 472 ASP A C   1 
ATOM   3052 O O   . ASP A 1 472 ? 90.575  116.102 92.308  1.00 70.07  ? 472 ASP A O   1 
ATOM   3053 C CB  . ASP A 1 472 ? 91.719  116.132 95.287  1.00 70.07  ? 472 ASP A CB  1 
ATOM   3054 C CG  . ASP A 1 472 ? 91.450  115.204 96.447  1.00 70.07  ? 472 ASP A CG  1 
ATOM   3055 O OD1 . ASP A 1 472 ? 90.977  114.076 96.201  1.00 70.07  ? 472 ASP A OD1 1 
ATOM   3056 O OD2 . ASP A 1 472 ? 91.708  115.599 97.602  1.00 70.07  ? 472 ASP A OD2 1 
ATOM   3057 N N   . PRO A 1 473 ? 92.554  117.134 92.251  1.00 73.12  ? 473 PRO A N   1 
ATOM   3058 C CA  . PRO A 1 473 ? 92.150  117.816 91.009  1.00 73.12  ? 473 PRO A CA  1 
ATOM   3059 C C   . PRO A 1 473 ? 92.160  116.927 89.777  1.00 73.12  ? 473 PRO A C   1 
ATOM   3060 O O   . PRO A 1 473 ? 91.604  117.333 88.749  1.00 73.12  ? 473 PRO A O   1 
ATOM   3061 C CB  . PRO A 1 473 ? 93.174  118.948 90.872  1.00 73.12  ? 473 PRO A CB  1 
ATOM   3062 C CG  . PRO A 1 473 ? 93.662  119.177 92.222  1.00 73.12  ? 473 PRO A CG  1 
ATOM   3063 C CD  . PRO A 1 473 ? 93.719  117.826 92.837  1.00 73.12  ? 473 PRO A CD  1 
ATOM   3064 N N   . LEU A 1 474 ? 92.760  115.741 89.837  1.00 69.64  ? 474 LEU A N   1 
ATOM   3065 C CA  . LEU A 1 474 ? 92.809  114.848 88.689  1.00 69.64  ? 474 LEU A CA  1 
ATOM   3066 C C   . LEU A 1 474 ? 91.694  113.810 88.680  1.00 69.64  ? 474 LEU A C   1 
ATOM   3067 O O   . LEU A 1 474 ? 91.578  113.059 87.708  1.00 69.64  ? 474 LEU A O   1 
ATOM   3068 C CB  . LEU A 1 474 ? 94.172  114.154 88.619  1.00 69.64  ? 474 LEU A CB  1 
ATOM   3069 C CG  . LEU A 1 474 ? 95.344  115.057 88.236  1.00 69.64  ? 474 LEU A CG  1 
ATOM   3070 C CD1 . LEU A 1 474 ? 96.653  114.303 88.304  1.00 69.64  ? 474 LEU A CD1 1 
ATOM   3071 C CD2 . LEU A 1 474 ? 95.134  115.616 86.846  1.00 69.64  ? 474 LEU A CD2 1 
ATOM   3072 N N   . THR A 1 475 ? 90.867  113.747 89.721  1.00 72.52  ? 475 THR A N   1 
ATOM   3073 C CA  . THR A 1 475 ? 89.723  112.837 89.730  1.00 72.52  ? 475 THR A CA  1 
ATOM   3074 C C   . THR A 1 475 ? 88.612  113.464 88.901  1.00 72.52  ? 475 THR A C   1 
ATOM   3075 O O   . THR A 1 475 ? 87.917  114.374 89.358  1.00 72.52  ? 475 THR A O   1 
ATOM   3076 C CB  . THR A 1 475 ? 89.250  112.565 91.152  1.00 72.52  ? 475 THR A CB  1 
ATOM   3077 O OG1 . THR A 1 475 ? 88.797  113.787 91.747  1.00 72.52  ? 475 THR A OG1 1 
ATOM   3078 C CG2 . THR A 1 475 ? 90.374  111.990 91.991  1.00 72.52  ? 475 THR A CG2 1 
ATOM   3079 N N   . VAL A 1 476 ? 88.435  112.977 87.679  1.00 76.12  ? 476 VAL A N   1 
ATOM   3080 C CA  . VAL A 1 476 ? 87.428  113.528 86.783  1.00 76.12  ? 476 VAL A CA  1 
ATOM   3081 C C   . VAL A 1 476 ? 86.039  113.052 87.185  1.00 76.12  ? 476 VAL A C   1 
ATOM   3082 O O   . VAL A 1 476 ? 85.340  113.721 87.944  1.00 76.12  ? 476 VAL A O   1 
ATOM   3083 C CB  . VAL A 1 476 ? 87.724  113.157 85.324  1.00 76.12  ? 476 VAL A CB  1 
ATOM   3084 C CG1 . VAL A 1 476 ? 86.634  113.694 84.411  1.00 76.12  ? 476 VAL A CG1 1 
ATOM   3085 C CG2 . VAL A 1 476 ? 89.088  113.680 84.910  1.00 76.12  ? 476 VAL A CG2 1 
ATOM   3086 N N   . THR A 1 505 ? 83.254  108.808 91.415  1.00 90.08  ? 505 THR A N   1 
ATOM   3087 C CA  . THR A 1 505 ? 84.554  108.659 90.776  1.00 90.08  ? 505 THR A CA  1 
ATOM   3088 C C   . THR A 1 505 ? 84.396  107.920 89.449  1.00 90.08  ? 505 THR A C   1 
ATOM   3089 O O   . THR A 1 505 ? 84.341  106.691 89.410  1.00 90.08  ? 505 THR A O   1 
ATOM   3090 C CB  . THR A 1 505 ? 85.546  107.905 91.687  1.00 90.08  ? 505 THR A CB  1 
ATOM   3091 O OG1 . THR A 1 505 ? 85.653  108.586 92.942  1.00 90.08  ? 505 THR A OG1 1 
ATOM   3092 C CG2 . THR A 1 505 ? 86.924  107.847 91.055  1.00 90.08  ? 505 THR A CG2 1 
ATOM   3093 N N   . ALA A 1 506 ? 84.291  108.682 88.360  1.00 87.20  ? 506 ALA A N   1 
ATOM   3094 C CA  . ALA A 1 506 ? 84.194  108.076 87.037  1.00 87.20  ? 506 ALA A CA  1 
ATOM   3095 C C   . ALA A 1 506 ? 85.574  107.696 86.516  1.00 87.20  ? 506 ALA A C   1 
ATOM   3096 O O   . ALA A 1 506 ? 85.861  106.518 86.285  1.00 87.20  ? 506 ALA A O   1 
ATOM   3097 C CB  . ALA A 1 506 ? 83.493  109.033 86.068  1.00 87.20  ? 506 ALA A CB  1 
ATOM   3098 N N   . LEU A 1 507 ? 86.441  108.685 86.333  1.00 82.72  ? 507 LEU A N   1 
ATOM   3099 C CA  . LEU A 1 507 ? 87.848  108.461 86.033  1.00 82.72  ? 507 LEU A CA  1 
ATOM   3100 C C   . LEU A 1 507 ? 88.657  108.839 87.261  1.00 82.72  ? 507 LEU A C   1 
ATOM   3101 O O   . LEU A 1 507 ? 88.619  109.992 87.701  1.00 82.72  ? 507 LEU A O   1 
ATOM   3102 C CB  . LEU A 1 507 ? 88.304  109.271 84.822  1.00 82.72  ? 507 LEU A CB  1 
ATOM   3103 C CG  . LEU A 1 507 ? 89.790  109.110 84.501  1.00 82.72  ? 507 LEU A CG  1 
ATOM   3104 C CD1 . LEU A 1 507 ? 90.123  107.670 84.157  1.00 82.72  ? 507 LEU A CD1 1 
ATOM   3105 C CD2 . LEU A 1 507 ? 90.193  110.041 83.373  1.00 82.72  ? 507 LEU A CD2 1 
ATOM   3106 N N   . ASP A 1 508 ? 89.377  107.870 87.810  1.00 75.90  ? 508 ASP A N   1 
ATOM   3107 C CA  . ASP A 1 508 ? 90.108  108.090 89.045  1.00 75.90  ? 508 ASP A CA  1 
ATOM   3108 C C   . ASP A 1 508 ? 91.344  108.936 88.774  1.00 75.90  ? 508 ASP A C   1 
ATOM   3109 O O   . ASP A 1 508 ? 91.887  108.949 87.667  1.00 75.90  ? 508 ASP A O   1 
ATOM   3110 C CB  . ASP A 1 508 ? 90.484  106.748 89.667  1.00 75.90  ? 508 ASP A CB  1 
ATOM   3111 C CG  . ASP A 1 508 ? 90.928  106.857 91.113  1.00 75.90  ? 508 ASP A CG  1 
ATOM   3112 O OD1 . ASP A 1 508 ? 91.042  107.977 91.653  1.00 75.90  ? 508 ASP A OD1 1 
ATOM   3113 O OD2 . ASP A 1 508 ? 91.139  105.791 91.720  1.00 75.90  ? 508 ASP A OD2 1 
ATOM   3114 N N   . GLY A 1 509 ? 91.775  109.665 89.803  1.00 69.83  ? 509 GLY A N   1 
ATOM   3115 C CA  . GLY A 1 509 ? 92.898  110.565 89.640  1.00 69.83  ? 509 GLY A CA  1 
ATOM   3116 C C   . GLY A 1 509 ? 94.243  109.900 89.802  1.00 69.83  ? 509 GLY A C   1 
ATOM   3117 O O   . GLY A 1 509 ? 95.236  110.380 89.248  1.00 69.83  ? 509 GLY A O   1 
ATOM   3118 N N   . TYR A 1 510 ? 94.299  108.794 90.549  1.00 66.75  ? 510 TYR A N   1 
ATOM   3119 C CA  . TYR A 1 510 ? 95.566  108.109 90.785  1.00 66.75  ? 510 TYR A CA  1 
ATOM   3120 C C   . TYR A 1 510 ? 96.157  107.518 89.514  1.00 66.75  ? 510 TYR A C   1 
ATOM   3121 O O   . TYR A 1 510 ? 97.376  107.544 89.341  1.00 66.75  ? 510 TYR A O   1 
ATOM   3122 C CB  . TYR A 1 510 ? 95.386  107.022 91.838  1.00 66.75  ? 510 TYR A CB  1 
ATOM   3123 C CG  . TYR A 1 510 ? 96.558  106.079 91.955  1.00 66.75  ? 510 TYR A CG  1 
ATOM   3124 C CD1 . TYR A 1 510 ? 97.774  106.508 92.460  1.00 66.75  ? 510 TYR A CD1 1 
ATOM   3125 C CD2 . TYR A 1 510 ? 96.438  104.752 91.570  1.00 66.75  ? 510 TYR A CD2 1 
ATOM   3126 C CE1 . TYR A 1 510 ? 98.841  105.644 92.572  1.00 66.75  ? 510 TYR A CE1 1 
ATOM   3127 C CE2 . TYR A 1 510 ? 97.496  103.883 91.677  1.00 66.75  ? 510 TYR A CE2 1 
ATOM   3128 C CZ  . TYR A 1 510 ? 98.694  104.332 92.179  1.00 66.75  ? 510 TYR A CZ  1 
ATOM   3129 O OH  . TYR A 1 510 ? 99.748  103.460 92.285  1.00 66.75  ? 510 TYR A OH  1 
ATOM   3130 N N   . TYR A 1 511 ? 95.325  107.031 88.595  1.00 69.85  ? 511 TYR A N   1 
ATOM   3131 C CA  . TYR A 1 511 ? 95.872  106.410 87.395  1.00 69.85  ? 511 TYR A CA  1 
ATOM   3132 C C   . TYR A 1 511 ? 96.412  107.450 86.422  1.00 69.85  ? 511 TYR A C   1 
ATOM   3133 O O   . TYR A 1 511 ? 97.501  107.268 85.864  1.00 69.85  ? 511 TYR A O   1 
ATOM   3134 C CB  . TYR A 1 511 ? 94.813  105.548 86.720  1.00 69.85  ? 511 TYR A CB  1 
ATOM   3135 C CG  . TYR A 1 511 ? 94.242  104.521 87.646  1.00 69.85  ? 511 TYR A CG  1 
ATOM   3136 C CD1 . TYR A 1 511 ? 94.964  103.395 88.004  1.00 69.85  ? 511 TYR A CD1 1 
ATOM   3137 C CD2 . TYR A 1 511 ? 92.971  104.679 88.163  1.00 69.85  ? 511 TYR A CD2 1 
ATOM   3138 C CE1 . TYR A 1 511 ? 94.430  102.460 88.864  1.00 69.85  ? 511 TYR A CE1 1 
ATOM   3139 C CE2 . TYR A 1 511 ? 92.430  103.756 89.015  1.00 69.85  ? 511 TYR A CE2 1 
ATOM   3140 C CZ  . TYR A 1 511 ? 93.158  102.647 89.364  1.00 69.85  ? 511 TYR A CZ  1 
ATOM   3141 O OH  . TYR A 1 511 ? 92.598  101.736 90.220  1.00 69.85  ? 511 TYR A OH  1 
ATOM   3142 N N   . VAL A 1 512 ? 95.678  108.549 86.219  1.00 67.69  ? 512 VAL A N   1 
ATOM   3143 C CA  . VAL A 1 512 ? 96.173  109.606 85.342  1.00 67.69  ? 512 VAL A CA  1 
ATOM   3144 C C   . VAL A 1 512 ? 97.366  110.309 85.983  1.00 67.69  ? 512 VAL A C   1 
ATOM   3145 O O   . VAL A 1 512 ? 98.306  110.709 85.284  1.00 67.69  ? 512 VAL A O   1 
ATOM   3146 C CB  . VAL A 1 512 ? 95.030  110.574 84.960  1.00 67.69  ? 512 VAL A CB  1 
ATOM   3147 C CG1 . VAL A 1 512 ? 94.471  111.312 86.163  1.00 67.69  ? 512 VAL A CG1 1 
ATOM   3148 C CG2 . VAL A 1 512 ? 95.476  111.555 83.880  1.00 67.69  ? 512 VAL A CG2 1 
ATOM   3149 N N   . GLU A 1 513 ? 97.408  110.371 87.316  1.00 65.62  ? 513 GLU A N   1 
ATOM   3150 C CA  . GLU A 1 513 ? 98.575  110.894 88.009  1.00 65.62  ? 513 GLU A CA  1 
ATOM   3151 C C   . GLU A 1 513 ? 99.780  109.979 87.854  1.00 65.62  ? 513 GLU A C   1 
ATOM   3152 O O   . GLU A 1 513 ? 100.903 110.457 87.670  1.00 65.62  ? 513 GLU A O   1 
ATOM   3153 C CB  . GLU A 1 513 ? 98.232  111.082 89.475  1.00 65.62  ? 513 GLU A CB  1 
ATOM   3154 C CG  . GLU A 1 513 ? 99.372  111.460 90.346  1.00 65.62  ? 513 GLU A CG  1 
ATOM   3155 C CD  . GLU A 1 513 ? 98.919  111.614 91.754  1.00 65.62  ? 513 GLU A CD  1 
ATOM   3156 O OE1 . GLU A 1 513 ? 97.698  111.559 91.986  1.00 65.62  ? 513 GLU A OE1 1 
ATOM   3157 O OE2 . GLU A 1 513 ? 99.776  111.729 92.636  1.00 65.62  ? 513 GLU A OE2 1 
ATOM   3158 N N   . SER A 1 514 ? 99.565  108.662 87.902  1.00 65.01  ? 514 SER A N   1 
ATOM   3159 C CA  . SER A 1 514 ? 100.665 107.722 87.738  1.00 65.01  ? 514 SER A CA  1 
ATOM   3160 C C   . SER A 1 514 ? 101.209 107.751 86.318  1.00 65.01  ? 514 SER A C   1 
ATOM   3161 O O   . SER A 1 514 ? 102.425 107.693 86.122  1.00 65.01  ? 514 SER A O   1 
ATOM   3162 C CB  . SER A 1 514 ? 100.214 106.313 88.111  1.00 65.01  ? 514 SER A CB  1 
ATOM   3163 O OG  . SER A 1 514 ? 101.267 105.386 87.936  1.00 65.01  ? 514 SER A OG  1 
ATOM   3164 N N   . ILE A 1 515 ? 100.330 107.889 85.320  1.00 65.02  ? 515 ILE A N   1 
ATOM   3165 C CA  . ILE A 1 515 ? 100.784 107.990 83.934  1.00 65.02  ? 515 ILE A CA  1 
ATOM   3166 C C   . ILE A 1 515 ? 101.559 109.287 83.705  1.00 65.02  ? 515 ILE A C   1 
ATOM   3167 O O   . ILE A 1 515 ? 102.636 109.278 83.088  1.00 65.02  ? 515 ILE A O   1 
ATOM   3168 C CB  . ILE A 1 515 ? 99.591  107.856 82.970  1.00 65.02  ? 515 ILE A CB  1 
ATOM   3169 C CG1 . ILE A 1 515 ? 98.987  106.460 83.066  1.00 65.02  ? 515 ILE A CG1 1 
ATOM   3170 C CG2 . ILE A 1 515 ? 100.012 108.111 81.538  1.00 65.02  ? 515 ILE A CG2 1 
ATOM   3171 C CD1 . ILE A 1 515 ? 97.672  106.329 82.344  1.00 65.02  ? 515 ILE A CD1 1 
ATOM   3172 N N   . ILE A 1 516 ? 101.057 110.411 84.235  1.00 64.59  ? 516 ILE A N   1 
ATOM   3173 C CA  . ILE A 1 516 ? 101.746 111.691 84.061  1.00 64.59  ? 516 ILE A CA  1 
ATOM   3174 C C   . ILE A 1 516 ? 103.078 111.704 84.807  1.00 64.59  ? 516 ILE A C   1 
ATOM   3175 O O   . ILE A 1 516 ? 104.091 112.173 84.276  1.00 64.59  ? 516 ILE A O   1 
ATOM   3176 C CB  . ILE A 1 516 ? 100.823 112.852 84.481  1.00 64.59  ? 516 ILE A CB  1 
ATOM   3177 C CG1 . ILE A 1 516 ? 99.676  112.997 83.480  1.00 64.59  ? 516 ILE A CG1 1 
ATOM   3178 C CG2 . ILE A 1 516 ? 101.576 114.168 84.603  1.00 64.59  ? 516 ILE A CG2 1 
ATOM   3179 C CD1 . ILE A 1 516 ? 100.131 113.273 82.064  1.00 64.59  ? 516 ILE A CD1 1 
ATOM   3180 N N   . CYS A 1 517 ? 103.128 111.125 86.007  1.00 65.56  ? 517 CYS A N   1 
ATOM   3181 C CA  . CYS A 1 517 ? 104.386 111.116 86.745  1.00 65.56  ? 517 CYS A CA  1 
ATOM   3182 C C   . CYS A 1 517 ? 105.383 110.118 86.171  1.00 65.56  ? 517 CYS A C   1 
ATOM   3183 O O   . CYS A 1 517 ? 106.587 110.357 86.249  1.00 65.56  ? 517 CYS A O   1 
ATOM   3184 C CB  . CYS A 1 517 ? 104.131 110.852 88.225  1.00 65.56  ? 517 CYS A CB  1 
ATOM   3185 S SG  . CYS A 1 517 ? 103.345 112.261 89.047  1.00 65.56  ? 517 CYS A SG  1 
ATOM   3186 N N   . VAL A 1 518 ? 104.922 109.031 85.549  1.00 61.02  ? 518 VAL A N   1 
ATOM   3187 C CA  . VAL A 1 518 ? 105.843 108.157 84.826  1.00 61.02  ? 518 VAL A CA  1 
ATOM   3188 C C   . VAL A 1 518 ? 106.399 108.859 83.591  1.00 61.02  ? 518 VAL A C   1 
ATOM   3189 O O   . VAL A 1 518 ? 107.583 108.710 83.258  1.00 61.02  ? 518 VAL A O   1 
ATOM   3190 C CB  . VAL A 1 518 ? 105.150 106.824 84.493  1.00 61.02  ? 518 VAL A CB  1 
ATOM   3191 C CG1 . VAL A 1 518 ? 105.855 106.080 83.381  1.00 61.02  ? 518 VAL A CG1 1 
ATOM   3192 C CG2 . VAL A 1 518 ? 105.158 105.955 85.728  1.00 61.02  ? 518 VAL A CG2 1 
ATOM   3193 N N   . PHE A 1 519 ? 105.576 109.670 82.920  1.00 63.89  ? 519 PHE A N   1 
ATOM   3194 C CA  . PHE A 1 519 ? 106.099 110.473 81.816  1.00 63.89  ? 519 PHE A CA  1 
ATOM   3195 C C   . PHE A 1 519 ? 107.112 111.507 82.302  1.00 63.89  ? 519 PHE A C   1 
ATOM   3196 O O   . PHE A 1 519 ? 108.118 111.750 81.630  1.00 63.89  ? 519 PHE A O   1 
ATOM   3197 C CB  . PHE A 1 519 ? 104.956 111.144 81.060  1.00 63.89  ? 519 PHE A CB  1 
ATOM   3198 C CG  . PHE A 1 519 ? 104.171 110.203 80.191  1.00 63.89  ? 519 PHE A CG  1 
ATOM   3199 C CD1 . PHE A 1 519 ? 104.688 108.965 79.840  1.00 63.89  ? 519 PHE A CD1 1 
ATOM   3200 C CD2 . PHE A 1 519 ? 102.917 110.559 79.724  1.00 63.89  ? 519 PHE A CD2 1 
ATOM   3201 C CE1 . PHE A 1 519 ? 103.970 108.099 79.042  1.00 63.89  ? 519 PHE A CE1 1 
ATOM   3202 C CE2 . PHE A 1 519 ? 102.191 109.697 78.924  1.00 63.89  ? 519 PHE A CE2 1 
ATOM   3203 C CZ  . PHE A 1 519 ? 102.720 108.465 78.583  1.00 63.89  ? 519 PHE A CZ  1 
ATOM   3204 N N   . ILE A 1 520 ? 106.895 112.071 83.495  1.00 65.08  ? 520 ILE A N   1 
ATOM   3205 C CA  . ILE A 1 520 ? 107.875 112.979 84.097  1.00 65.08  ? 520 ILE A CA  1 
ATOM   3206 C C   . ILE A 1 520 ? 109.160 112.233 84.456  1.00 65.08  ? 520 ILE A C   1 
ATOM   3207 O O   . ILE A 1 520 ? 110.267 112.742 84.250  1.00 65.08  ? 520 ILE A O   1 
ATOM   3208 C CB  . ILE A 1 520 ? 107.260 113.694 85.318  1.00 65.08  ? 520 ILE A CB  1 
ATOM   3209 C CG1 . ILE A 1 520 ? 106.128 114.620 84.876  1.00 65.08  ? 520 ILE A CG1 1 
ATOM   3210 C CG2 . ILE A 1 520 ? 108.292 114.498 86.092  1.00 65.08  ? 520 ILE A CG2 1 
ATOM   3211 C CD1 . ILE A 1 520 ? 106.564 115.700 83.908  1.00 65.08  ? 520 ILE A CD1 1 
ATOM   3212 N N   . GLY A 1 521 ? 109.038 110.997 84.937  1.00 65.56  ? 521 GLY A N   1 
ATOM   3213 C CA  . GLY A 1 521 ? 110.221 110.244 85.326  1.00 65.56  ? 521 GLY A CA  1 
ATOM   3214 C C   . GLY A 1 521 ? 111.050 109.771 84.147  1.00 65.56  ? 521 GLY A C   1 
ATOM   3215 O O   . GLY A 1 521 ? 112.279 109.845 84.177  1.00 65.56  ? 521 GLY A O   1 
ATOM   3216 N N   . PHE A 1 522 ? 110.398 109.292 83.088  1.00 67.47  ? 522 PHE A N   1 
ATOM   3217 C CA  . PHE A 1 522 ? 111.143 108.936 81.884  1.00 67.47  ? 522 PHE A CA  1 
ATOM   3218 C C   . PHE A 1 522 ? 111.627 110.165 81.127  1.00 67.47  ? 522 PHE A C   1 
ATOM   3219 O O   . PHE A 1 522 ? 112.635 110.082 80.419  1.00 67.47  ? 522 PHE A O   1 
ATOM   3220 C CB  . PHE A 1 522 ? 110.309 108.036 80.973  1.00 67.47  ? 522 PHE A CB  1 
ATOM   3221 C CG  . PHE A 1 522 ? 110.363 106.582 81.345  1.00 67.47  ? 522 PHE A CG  1 
ATOM   3222 C CD1 . PHE A 1 522 ? 111.414 106.088 82.091  1.00 67.47  ? 522 PHE A CD1 1 
ATOM   3223 C CD2 . PHE A 1 522 ? 109.365 105.712 80.950  1.00 67.47  ? 522 PHE A CD2 1 
ATOM   3224 C CE1 . PHE A 1 522 ? 111.469 104.755 82.436  1.00 67.47  ? 522 PHE A CE1 1 
ATOM   3225 C CE2 . PHE A 1 522 ? 109.414 104.377 81.297  1.00 67.47  ? 522 PHE A CE2 1 
ATOM   3226 C CZ  . PHE A 1 522 ? 110.467 103.901 82.041  1.00 67.47  ? 522 PHE A CZ  1 
ATOM   3227 N N   . GLY A 1 523 ? 110.954 111.309 81.276  1.00 71.81  ? 523 GLY A N   1 
ATOM   3228 C CA  . GLY A 1 523 ? 111.517 112.548 80.769  1.00 71.81  ? 523 GLY A CA  1 
ATOM   3229 C C   . GLY A 1 523 ? 112.785 112.934 81.503  1.00 71.81  ? 523 GLY A C   1 
ATOM   3230 O O   . GLY A 1 523 ? 113.776 113.322 80.875  1.00 71.81  ? 523 GLY A O   1 
ATOM   3231 N N   . TRP A 1 524 ? 112.776 112.795 82.837  1.00 75.70  ? 524 TRP A N   1 
ATOM   3232 C CA  . TRP A 1 524 ? 113.984 112.971 83.640  1.00 75.70  ? 524 TRP A CA  1 
ATOM   3233 C C   . TRP A 1 524 ? 115.076 112.008 83.208  1.00 75.70  ? 524 TRP A C   1 
ATOM   3234 O O   . TRP A 1 524 ? 116.240 112.398 83.091  1.00 75.70  ? 524 TRP A O   1 
ATOM   3235 C CB  . TRP A 1 524 ? 113.692 112.744 85.123  1.00 75.70  ? 524 TRP A CB  1 
ATOM   3236 C CG  . TRP A 1 524 ? 114.893 113.011 85.980  1.00 75.70  ? 524 TRP A CG  1 
ATOM   3237 C CD1 . TRP A 1 524 ? 115.322 114.220 86.423  1.00 75.70  ? 524 TRP A CD1 1 
ATOM   3238 C CD2 . TRP A 1 524 ? 115.885 112.061 86.393  1.00 75.70  ? 524 TRP A CD2 1 
ATOM   3239 N NE1 . TRP A 1 524 ? 116.483 114.081 87.140  1.00 75.70  ? 524 TRP A NE1 1 
ATOM   3240 C CE2 . TRP A 1 524 ? 116.855 112.764 87.128  1.00 75.70  ? 524 TRP A CE2 1 
ATOM   3241 C CE3 . TRP A 1 524 ? 116.035 110.683 86.226  1.00 75.70  ? 524 TRP A CE3 1 
ATOM   3242 C CZ2 . TRP A 1 524 ? 117.958 112.136 87.694  1.00 75.70  ? 524 TRP A CZ2 1 
ATOM   3243 C CZ3 . TRP A 1 524 ? 117.132 110.065 86.784  1.00 75.70  ? 524 TRP A CZ3 1 
ATOM   3244 C CH2 . TRP A 1 524 ? 118.072 110.788 87.520  1.00 75.70  ? 524 TRP A CH2 1 
ATOM   3245 N N   . TRP A 1 525 ? 114.709 110.751 82.959  1.00 73.18  ? 525 TRP A N   1 
ATOM   3246 C CA  . TRP A 1 525 ? 115.673 109.718 82.595  1.00 73.18  ? 525 TRP A CA  1 
ATOM   3247 C C   . TRP A 1 525 ? 116.331 110.036 81.257  1.00 73.18  ? 525 TRP A C   1 
ATOM   3248 O O   . TRP A 1 525 ? 117.543 110.258 81.187  1.00 73.18  ? 525 TRP A O   1 
ATOM   3249 C CB  . TRP A 1 525 ? 114.958 108.369 82.549  1.00 73.18  ? 525 TRP A CB  1 
ATOM   3250 C CG  . TRP A 1 525 ? 115.826 107.175 82.382  1.00 73.18  ? 525 TRP A CG  1 
ATOM   3251 C CD1 . TRP A 1 525 ? 116.658 106.634 83.309  1.00 73.18  ? 525 TRP A CD1 1 
ATOM   3252 C CD2 . TRP A 1 525 ? 115.943 106.362 81.212  1.00 73.18  ? 525 TRP A CD2 1 
ATOM   3253 N NE1 . TRP A 1 525 ? 117.284 105.528 82.794  1.00 73.18  ? 525 TRP A NE1 1 
ATOM   3254 C CE2 . TRP A 1 525 ? 116.865 105.342 81.504  1.00 73.18  ? 525 TRP A CE2 1 
ATOM   3255 C CE3 . TRP A 1 525 ? 115.356 106.400 79.944  1.00 73.18  ? 525 TRP A CE3 1 
ATOM   3256 C CZ2 . TRP A 1 525 ? 117.217 104.368 80.576  1.00 73.18  ? 525 TRP A CZ2 1 
ATOM   3257 C CZ3 . TRP A 1 525 ? 115.705 105.432 79.023  1.00 73.18  ? 525 TRP A CZ3 1 
ATOM   3258 C CH2 . TRP A 1 525 ? 116.627 104.430 79.344  1.00 73.18  ? 525 TRP A CH2 1 
ATOM   3259 N N   . PHE A 1 526 ? 115.524 110.155 80.200  1.00 78.85  ? 526 PHE A N   1 
ATOM   3260 C CA  . PHE A 1 526 ? 116.036 110.390 78.856  1.00 78.85  ? 526 PHE A CA  1 
ATOM   3261 C C   . PHE A 1 526 ? 116.654 111.778 78.686  1.00 78.85  ? 526 PHE A C   1 
ATOM   3262 O O   . PHE A 1 526 ? 117.463 111.968 77.772  1.00 78.85  ? 526 PHE A O   1 
ATOM   3263 C CB  . PHE A 1 526 ? 114.902 110.169 77.848  1.00 78.85  ? 526 PHE A CB  1 
ATOM   3264 C CG  . PHE A 1 526 ? 115.323 110.274 76.408  1.00 78.85  ? 526 PHE A CG  1 
ATOM   3265 C CD1 . PHE A 1 526 ? 116.061 109.263 75.810  1.00 78.85  ? 526 PHE A CD1 1 
ATOM   3266 C CD2 . PHE A 1 526 ? 114.968 111.379 75.648  1.00 78.85  ? 526 PHE A CD2 1 
ATOM   3267 C CE1 . PHE A 1 526 ? 116.446 109.357 74.483  1.00 78.85  ? 526 PHE A CE1 1 
ATOM   3268 C CE2 . PHE A 1 526 ? 115.348 111.480 74.320  1.00 78.85  ? 526 PHE A CE2 1 
ATOM   3269 C CZ  . PHE A 1 526 ? 116.088 110.467 73.738  1.00 78.85  ? 526 PHE A CZ  1 
ATOM   3270 N N   . PHE A 1 527 ? 116.339 112.742 79.554  1.00 81.54  ? 527 PHE A N   1 
ATOM   3271 C CA  . PHE A 1 527 ? 116.932 114.065 79.420  1.00 81.54  ? 527 PHE A CA  1 
ATOM   3272 C C   . PHE A 1 527 ? 118.134 114.299 80.322  1.00 81.54  ? 527 PHE A C   1 
ATOM   3273 O O   . PHE A 1 527 ? 119.001 115.105 79.971  1.00 81.54  ? 527 PHE A O   1 
ATOM   3274 C CB  . PHE A 1 527 ? 115.888 115.149 79.709  1.00 81.54  ? 527 PHE A CB  1 
ATOM   3275 C CG  . PHE A 1 527 ? 114.856 115.309 78.630  1.00 81.54  ? 527 PHE A CG  1 
ATOM   3276 C CD1 . PHE A 1 527 ? 115.066 114.795 77.359  1.00 81.54  ? 527 PHE A CD1 1 
ATOM   3277 C CD2 . PHE A 1 527 ? 113.672 115.981 78.890  1.00 81.54  ? 527 PHE A CD2 1 
ATOM   3278 C CE1 . PHE A 1 527 ? 114.114 114.947 76.368  1.00 81.54  ? 527 PHE A CE1 1 
ATOM   3279 C CE2 . PHE A 1 527 ? 112.715 116.137 77.904  1.00 81.54  ? 527 PHE A CE2 1 
ATOM   3280 C CZ  . PHE A 1 527 ? 112.937 115.619 76.641  1.00 81.54  ? 527 PHE A CZ  1 
ATOM   3281 N N   . LEU A 1 528 ? 118.221 113.623 81.474  1.00 82.54  ? 528 LEU A N   1 
ATOM   3282 C CA  . LEU A 1 528 ? 119.231 113.932 82.476  1.00 82.54  ? 528 LEU A CA  1 
ATOM   3283 C C   . LEU A 1 528 ? 119.965 112.682 82.950  1.00 82.54  ? 528 LEU A C   1 
ATOM   3284 O O   . LEU A 1 528 ? 120.573 112.698 84.024  1.00 82.54  ? 528 LEU A O   1 
ATOM   3285 C CB  . LEU A 1 528 ? 118.592 114.651 83.667  1.00 82.54  ? 528 LEU A CB  1 
ATOM   3286 C CG  . LEU A 1 528 ? 117.938 116.007 83.390  1.00 82.54  ? 528 LEU A CG  1 
ATOM   3287 C CD1 . LEU A 1 528 ? 117.262 116.559 84.627  1.00 82.54  ? 528 LEU A CD1 1 
ATOM   3288 C CD2 . LEU A 1 528 ? 118.953 116.991 82.847  1.00 82.54  ? 528 LEU A CD2 1 
ATOM   3289 N N   . GLY A 1 529 ? 119.918 111.600 82.179  1.00 84.17  ? 529 GLY A N   1 
ATOM   3290 C CA  . GLY A 1 529 ? 120.705 110.425 82.459  1.00 84.17  ? 529 GLY A CA  1 
ATOM   3291 C C   . GLY A 1 529 ? 122.205 110.619 82.375  1.00 84.17  ? 529 GLY A C   1 
ATOM   3292 O O   . GLY A 1 529 ? 122.917 110.392 83.358  1.00 84.17  ? 529 GLY A O   1 
ATOM   3293 N N   . PRO A 1 530 ? 122.724 110.996 81.196  1.00 87.58  ? 530 PRO A N   1 
ATOM   3294 C CA  . PRO A 1 530 ? 124.178 111.207 81.077  1.00 87.58  ? 530 PRO A CA  1 
ATOM   3295 C C   . PRO A 1 530 ? 124.736 112.323 81.946  1.00 87.58  ? 530 PRO A C   1 
ATOM   3296 O O   . PRO A 1 530 ? 125.890 112.217 82.374  1.00 87.58  ? 530 PRO A O   1 
ATOM   3297 C CB  . PRO A 1 530 ? 124.362 111.507 79.583  1.00 87.58  ? 530 PRO A CB  1 
ATOM   3298 C CG  . PRO A 1 530 ? 123.247 110.793 78.931  1.00 87.58  ? 530 PRO A CG  1 
ATOM   3299 C CD  . PRO A 1 530 ? 122.088 110.925 79.866  1.00 87.58  ? 530 PRO A CD  1 
ATOM   3300 N N   . LYS A 1 531 ? 123.955 113.364 82.257  1.00 86.02  ? 531 LYS A N   1 
ATOM   3301 C CA  . LYS A 1 531 ? 124.443 114.387 83.182  1.00 86.02  ? 531 LYS A CA  1 
ATOM   3302 C C   . LYS A 1 531 ? 124.595 113.831 84.591  1.00 86.02  ? 531 LYS A C   1 
ATOM   3303 O O   . LYS A 1 531 ? 125.621 114.054 85.249  1.00 86.02  ? 531 LYS A O   1 
ATOM   3304 C CB  . LYS A 1 531 ? 123.511 115.597 83.193  1.00 86.02  ? 531 LYS A CB  1 
ATOM   3305 C CG  . LYS A 1 531 ? 123.577 116.454 81.948  1.00 86.02  ? 531 LYS A CG  1 
ATOM   3306 C CD  . LYS A 1 531 ? 122.598 117.607 82.039  1.00 86.02  ? 531 LYS A CD  1 
ATOM   3307 C CE  . LYS A 1 531 ? 123.049 118.611 83.086  1.00 86.02  ? 531 LYS A CE  1 
ATOM   3308 N NZ  . LYS A 1 531 ? 122.182 119.821 83.119  1.00 86.02  ? 531 LYS A NZ  1 
ATOM   3309 N N   . PHE A 1 532 ? 123.597 113.079 85.059  1.00 79.97  ? 532 PHE A N   1 
ATOM   3310 C CA  . PHE A 1 532 ? 123.666 112.506 86.395  1.00 79.97  ? 532 PHE A CA  1 
ATOM   3311 C C   . PHE A 1 532 ? 124.685 111.378 86.472  1.00 79.97  ? 532 PHE A C   1 
ATOM   3312 O O   . PHE A 1 532 ? 125.184 111.080 87.560  1.00 79.97  ? 532 PHE A O   1 
ATOM   3313 C CB  . PHE A 1 532 ? 122.287 112.005 86.815  1.00 79.97  ? 532 PHE A CB  1 
ATOM   3314 C CG  . PHE A 1 532 ? 122.153 111.769 88.284  1.00 79.97  ? 532 PHE A CG  1 
ATOM   3315 C CD1 . PHE A 1 532 ? 121.955 112.833 89.139  1.00 79.97  ? 532 PHE A CD1 1 
ATOM   3316 C CD2 . PHE A 1 532 ? 122.233 110.498 88.812  1.00 79.97  ? 532 PHE A CD2 1 
ATOM   3317 C CE1 . PHE A 1 532 ? 121.828 112.635 90.493  1.00 79.97  ? 532 PHE A CE1 1 
ATOM   3318 C CE2 . PHE A 1 532 ? 122.113 110.299 90.171  1.00 79.97  ? 532 PHE A CE2 1 
ATOM   3319 C CZ  . PHE A 1 532 ? 121.907 111.364 91.006  1.00 79.97  ? 532 PHE A CZ  1 
ATOM   3320 N N   . LYS A 1 533 ? 125.009 110.754 85.338  1.00 85.01  ? 533 LYS A N   1 
ATOM   3321 C CA  . LYS A 1 533 ? 126.070 109.757 85.292  1.00 85.01  ? 533 LYS A CA  1 
ATOM   3322 C C   . LYS A 1 533 ? 127.451 110.404 85.238  1.00 85.01  ? 533 LYS A C   1 
ATOM   3323 O O   . LYS A 1 533 ? 128.417 109.832 85.750  1.00 85.01  ? 533 LYS A O   1 
ATOM   3324 C CB  . LYS A 1 533 ? 125.857 108.837 84.086  1.00 85.01  ? 533 LYS A CB  1 
ATOM   3325 C CG  . LYS A 1 533 ? 126.786 107.636 83.995  1.00 85.01  ? 533 LYS A CG  1 
ATOM   3326 C CD  . LYS A 1 533 ? 126.433 106.768 82.795  1.00 85.01  ? 533 LYS A CD  1 
ATOM   3327 C CE  . LYS A 1 533 ? 127.358 105.568 82.678  1.00 85.01  ? 533 LYS A CE  1 
ATOM   3328 N NZ  . LYS A 1 533 ? 127.016 104.720 81.502  1.00 85.01  ? 533 LYS A NZ  1 
ATOM   3329 N N   . LYS A 1 534 ? 127.570 111.587 84.635  1.00 88.53  ? 534 LYS A N   1 
ATOM   3330 C CA  . LYS A 1 534 ? 128.846 112.290 84.622  1.00 88.53  ? 534 LYS A CA  1 
ATOM   3331 C C   . LYS A 1 534 ? 129.085 113.131 85.869  1.00 88.53  ? 534 LYS A C   1 
ATOM   3332 O O   . LYS A 1 534 ? 130.196 113.644 86.037  1.00 88.53  ? 534 LYS A O   1 
ATOM   3333 C CB  . LYS A 1 534 ? 128.954 113.183 83.383  1.00 88.53  ? 534 LYS A CB  1 
ATOM   3334 C CG  . LYS A 1 534 ? 129.142 112.429 82.076  1.00 88.53  ? 534 LYS A CG  1 
ATOM   3335 C CD  . LYS A 1 534 ? 129.408 113.390 80.927  1.00 88.53  ? 534 LYS A CD  1 
ATOM   3336 C CE  . LYS A 1 534 ? 128.145 114.139 80.533  1.00 88.53  ? 534 LYS A CE  1 
ATOM   3337 N NZ  . LYS A 1 534 ? 128.357 115.005 79.341  1.00 88.53  ? 534 LYS A NZ  1 
ATOM   3338 N N   . LEU A 1 535 ? 128.080 113.301 86.736  1.00 89.70  ? 535 LEU A N   1 
ATOM   3339 C CA  . LEU A 1 535 ? 128.322 114.014 87.992  1.00 89.70  ? 535 LEU A CA  1 
ATOM   3340 C C   . LEU A 1 535 ? 129.213 113.252 88.968  1.00 89.70  ? 535 LEU A C   1 
ATOM   3341 O O   . LEU A 1 535 ? 129.734 113.866 89.904  1.00 89.70  ? 535 LEU A O   1 
ATOM   3342 C CB  . LEU A 1 535 ? 127.012 114.359 88.701  1.00 89.70  ? 535 LEU A CB  1 
ATOM   3343 C CG  . LEU A 1 535 ? 126.206 115.528 88.145  1.00 89.70  ? 535 LEU A CG  1 
ATOM   3344 C CD1 . LEU A 1 535 ? 124.902 115.675 88.902  1.00 89.70  ? 535 LEU A CD1 1 
ATOM   3345 C CD2 . LEU A 1 535 ? 127.021 116.806 88.223  1.00 89.70  ? 535 LEU A CD2 1 
ATOM   3346 N N   . GLN A 1 536 ? 129.406 111.948 88.788  1.00 89.23  ? 536 GLN A N   1 
ATOM   3347 C CA  . GLN A 1 536 ? 130.241 111.170 89.695  1.00 89.23  ? 536 GLN A CA  1 
ATOM   3348 C C   . GLN A 1 536 ? 131.715 111.189 89.309  1.00 89.23  ? 536 GLN A C   1 
ATOM   3349 O O   . GLN A 1 536 ? 132.507 110.446 89.898  1.00 89.23  ? 536 GLN A O   1 
ATOM   3350 C CB  . GLN A 1 536 ? 129.740 109.726 89.766  1.00 89.23  ? 536 GLN A CB  1 
ATOM   3351 C CG  . GLN A 1 536 ? 129.919 108.955 88.486  1.00 89.23  ? 536 GLN A CG  1 
ATOM   3352 C CD  . GLN A 1 536 ? 129.282 107.588 88.537  1.00 89.23  ? 536 GLN A CD  1 
ATOM   3353 O OE1 . GLN A 1 536 ? 128.745 107.179 89.564  1.00 89.23  ? 536 GLN A OE1 1 
ATOM   3354 N NE2 . GLN A 1 536 ? 129.325 106.876 87.420  1.00 89.23  ? 536 GLN A NE2 1 
ATOM   3355 N N   . ASP A 1 537 ? 132.102 112.021 88.349  1.00 87.45  ? 537 ASP A N   1 
ATOM   3356 C CA  . ASP A 1 537 ? 133.493 112.116 87.930  1.00 87.45  ? 537 ASP A CA  1 
ATOM   3357 C C   . ASP A 1 537 ? 133.994 113.552 88.026  1.00 87.45  ? 537 ASP A C   1 
ATOM   3358 O O   . ASP A 1 537 ? 133.813 114.215 89.047  1.00 87.45  ? 537 ASP A O   1 
ATOM   3359 C CB  . ASP A 1 537 ? 133.656 111.592 86.503  1.00 87.45  ? 537 ASP A CB  1 
ATOM   3360 C CG  . ASP A 1 537 ? 133.438 110.098 86.405  1.00 87.45  ? 537 ASP A CG  1 
ATOM   3361 O OD1 . ASP A 1 537 ? 133.711 109.392 87.397  1.00 87.45  ? 537 ASP A OD1 1 
ATOM   3362 O OD2 . ASP A 1 537 ? 132.990 109.628 85.339  1.00 87.45  ? 537 ASP A OD2 1 
HETATM 3363 N N1A . ACO B 2 .   ? 101.420 97.451  98.245  1.00 88.10  ? 601 ACO A N1A 1 
HETATM 3364 C C2A . ACO B 2 .   ? 101.368 97.059  99.538  1.00 88.10  ? 601 ACO A C2A 1 
HETATM 3365 N N3A . ACO B 2 .   ? 101.837 97.878  100.509 1.00 88.10  ? 601 ACO A N3A 1 
HETATM 3366 C C4A . ACO B 2 .   ? 102.350 99.078  100.188 1.00 88.10  ? 601 ACO A C4A 1 
HETATM 3367 C C5A . ACO B 2 .   ? 102.400 99.465  98.913  1.00 88.10  ? 601 ACO A C5A 1 
HETATM 3368 C C6A . ACO B 2 .   ? 101.920 98.624  97.935  1.00 88.10  ? 601 ACO A C6A 1 
HETATM 3369 N N6A . ACO B 2 .   ? 101.905 98.923  96.488  1.00 88.10  ? 601 ACO A N6A 1 
HETATM 3370 N N7A . ACO B 2 .   ? 102.951 100.686 98.865  1.00 88.10  ? 601 ACO A N7A 1 
HETATM 3371 C C8A . ACO B 2 .   ? 103.242 101.050 100.123 1.00 88.10  ? 601 ACO A C8A 1 
HETATM 3372 N N9A . ACO B 2 .   ? 102.869 100.057 100.946 1.00 88.10  ? 601 ACO A N9A 1 
HETATM 3373 C C1B . ACO B 2 .   ? 102.969 99.950  102.362 1.00 88.10  ? 601 ACO A C1B 1 
HETATM 3374 C C2B . ACO B 2 .   ? 104.357 100.363 102.840 1.00 88.10  ? 601 ACO A C2B 1 
HETATM 3375 O O2B . ACO B 2 .   ? 104.818 99.464  103.899 1.00 88.10  ? 601 ACO A O2B 1 
HETATM 3376 C C3B . ACO B 2 .   ? 104.121 101.764 103.423 1.00 88.10  ? 601 ACO A C3B 1 
HETATM 3377 O O3B . ACO B 2 .   ? 104.705 101.865 104.623 1.00 88.10  ? 601 ACO A O3B 1 
HETATM 3378 P P3B . ACO B 2 .   ? 106.288 102.352 104.677 1.00 88.10  ? 601 ACO A P3B 1 
HETATM 3379 O O7A . ACO B 2 .   ? 106.848 102.481 103.283 1.00 88.10  ? 601 ACO A O7A 1 
HETATM 3380 O O8A . ACO B 2 .   ? 107.103 101.326 105.443 1.00 88.10  ? 601 ACO A O8A 1 
HETATM 3381 O O9A . ACO B 2 .   ? 106.371 103.696 105.366 1.00 88.10  ? 601 ACO A O9A 1 
HETATM 3382 C C4B . ACO B 2 .   ? 102.540 101.848 103.522 1.00 88.10  ? 601 ACO A C4B 1 
HETATM 3383 O O4B . ACO B 2 .   ? 102.016 100.744 103.016 1.00 88.10  ? 601 ACO A O4B 1 
HETATM 3384 C C5B . ACO B 2 .   ? 101.997 103.063 102.746 1.00 88.10  ? 601 ACO A C5B 1 
HETATM 3385 O O5B . ACO B 2 .   ? 103.059 103.925 102.324 1.00 88.10  ? 601 ACO A O5B 1 
HETATM 3386 P P1A . ACO B 2 .   ? 103.126 105.458 102.993 1.00 88.10  ? 601 ACO A P1A 1 
HETATM 3387 O O1A . ACO B 2 .   ? 103.668 105.370 104.415 1.00 88.10  ? 601 ACO A O1A 1 
HETATM 3388 O O2A . ACO B 2 .   ? 101.745 106.047 103.023 1.00 88.10  ? 601 ACO A O2A 1 
HETATM 3389 O O3A . ACO B 2 .   ? 104.129 106.431 102.071 1.00 88.10  ? 601 ACO A O3A 1 
HETATM 3390 P P2A . ACO B 2 .   ? 104.603 107.939 102.545 1.00 88.10  ? 601 ACO A P2A 1 
HETATM 3391 O O4A . ACO B 2 .   ? 103.542 108.535 103.434 1.00 88.10  ? 601 ACO A O4A 1 
HETATM 3392 O O5A . ACO B 2 .   ? 104.783 108.813 101.339 1.00 88.10  ? 601 ACO A O5A 1 
HETATM 3393 O O6A . ACO B 2 .   ? 106.061 107.813 103.385 1.00 88.10  ? 601 ACO A O6A 1 
HETATM 3394 C CBP . ACO B 2 .   ? 108.177 106.594 103.038 1.00 88.10  ? 601 ACO A CBP 1 
HETATM 3395 C CCP . ACO B 2 .   ? 106.685 106.510 103.469 1.00 88.10  ? 601 ACO A CCP 1 
HETATM 3396 C CDP . ACO B 2 .   ? 108.923 107.552 103.992 1.00 88.10  ? 601 ACO A CDP 1 
HETATM 3397 C CEP . ACO B 2 .   ? 108.808 105.198 103.189 1.00 88.10  ? 601 ACO A CEP 1 
HETATM 3398 C CAP . ACO B 2 .   ? 108.300 107.001 101.580 1.00 88.10  ? 601 ACO A CAP 1 
HETATM 3399 O OAP . ACO B 2 .   ? 107.136 106.640 100.895 1.00 88.10  ? 601 ACO A OAP 1 
HETATM 3400 C C9P . ACO B 2 .   ? 108.570 108.531 101.350 1.00 88.10  ? 601 ACO A C9P 1 
HETATM 3401 O O9P . ACO B 2 .   ? 107.712 109.343 101.535 1.00 88.10  ? 601 ACO A O9P 1 
HETATM 3402 N N8P . ACO B 2 .   ? 109.895 108.976 100.863 1.00 88.10  ? 601 ACO A N8P 1 
HETATM 3403 C C7P . ACO B 2 .   ? 110.970 107.984 100.611 1.00 88.10  ? 601 ACO A C7P 1 
HETATM 3404 C C6P . ACO B 2 .   ? 112.346 108.697 100.587 1.00 88.10  ? 601 ACO A C6P 1 
HETATM 3405 C C5P . ACO B 2 .   ? 113.361 107.880 101.439 1.00 88.10  ? 601 ACO A C5P 1 
HETATM 3406 O O5P . ACO B 2 .   ? 113.772 106.852 101.036 1.00 88.10  ? 601 ACO A O5P 1 
HETATM 3407 N N4P . ACO B 2 .   ? 113.805 108.384 102.751 1.00 88.10  ? 601 ACO A N4P 1 
HETATM 3408 C C3P . ACO B 2 .   ? 113.300 109.671 103.269 1.00 88.10  ? 601 ACO A C3P 1 
HETATM 3409 C C2P . ACO B 2 .   ? 112.099 109.447 104.225 1.00 88.10  ? 601 ACO A C2P 1 
HETATM 3410 S S1P . ACO B 2 .   ? 112.653 108.666 105.781 1.00 88.10  ? 601 ACO A S1P 1 
HETATM 3411 C C   . ACO B 2 .   ? 111.203 108.521 106.871 1.00 88.10  ? 601 ACO A C   1 
HETATM 3412 O O   . ACO B 2 .   ? 111.007 107.516 107.485 1.00 88.10  ? 601 ACO A O   1 
HETATM 3413 C CH3 . ACO B 2 .   ? 110.233 109.698 106.986 1.00 88.10  ? 601 ACO A CH3 1 
# 
