data_9LYF
# 
_entry.id   9LYF 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9LYF         pdb_00009lyf 10.2210/pdb9lyf/pdb 
WWPDB D_1300056825 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-05-21 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9LYF 
_pdbx_database_status.recvd_initial_deposition_date   2025-02-20 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              Nithya_Baburajendran@eddc.sg 
_pdbx_contact_author.name_first         Nithya 
_pdbx_contact_author.name_last          Baburajendran 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-7013-9580 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Anantharajan, J.'  1 ? 
'Baburajendran, N.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   NE 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'J.Comput.Aided Mol.Des.' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1573-4951 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            39 
_citation.language                  ? 
_citation.page_first                19 
_citation.page_last                 19 
_citation.title                     'Structure-based discovery of novel non-covalent small molecule inhibitors of USP30.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1007/s10822-025-00596-2 
_citation.pdbx_database_id_PubMed   40274689 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Anbazhagan, P.'    1 ?                   
primary 'Anantharajan, J.'  2 ?                   
primary 'Fulwood, J.'       3 ?                   
primary 'Low, C.H.'         4 ?                   
primary 'Baburajendran, N.' 5 ?                   
primary 'Foo, K.'           6 ?                   
primary 'Xu, W.'            7 0000-0002-3566-1082 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Ubiquitin carboxyl-terminal hydrolase 30'                                                               
38469.422 1  3.4.19.12 F348D,M350S,I353E ? ? 
2 non-polymer syn '5-(3-cyanophenyl)-~{N}-[[(3~{S})-1-(iminomethyl)pyrrolidin-3-yl]methyl]-1,3,4-oxadiazole-2-carboxamide' 324.337 
1  ?         ?                 ? ? 
3 non-polymer syn 'ZINC ION'                                                                                               65.409 
1  ?         ?                 ? ? 
4 water       nat water                                                                                                    18.015 
16 ?         ?                 ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
'Deubiquitinating enzyme 30,Ubiquitin thioesterase 30,Ubiquitin-specific-processing protease 30,Ub-specific protease 30' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GPKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDAS
CLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDGSGSHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSI
PAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGT
PLKRHEHVQFNEDLSMDEYKYHSNASTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASL
QEVLSSSAYLLFYERV
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GPKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDAS
CLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDGSGSHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSI
PAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGT
PLKRHEHVQFNEDLSMDEYKYHSNASTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASL
QEVLSSSAYLLFYERV
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 '5-(3-cyanophenyl)-~{N}-[[(3~{S})-1-(iminomethyl)pyrrolidin-3-yl]methyl]-1,3,4-oxadiazole-2-carboxamide' A1L7W 
3 'ZINC ION'                                                                                               ZN    
4 water                                                                                                    HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   LYS n 
1 4   GLY n 
1 5   LEU n 
1 6   VAL n 
1 7   PRO n 
1 8   GLY n 
1 9   LEU n 
1 10  VAL n 
1 11  ASN n 
1 12  LEU n 
1 13  GLY n 
1 14  ASN n 
1 15  THR n 
1 16  CYS n 
1 17  PHE n 
1 18  MET n 
1 19  ASN n 
1 20  SER n 
1 21  LEU n 
1 22  LEU n 
1 23  GLN n 
1 24  GLY n 
1 25  LEU n 
1 26  SER n 
1 27  ALA n 
1 28  CYS n 
1 29  PRO n 
1 30  ALA n 
1 31  PHE n 
1 32  ILE n 
1 33  ARG n 
1 34  TRP n 
1 35  LEU n 
1 36  GLU n 
1 37  GLU n 
1 38  PHE n 
1 39  THR n 
1 40  SER n 
1 41  GLN n 
1 42  TYR n 
1 43  SER n 
1 44  ARG n 
1 45  ASP n 
1 46  GLN n 
1 47  LYS n 
1 48  GLU n 
1 49  PRO n 
1 50  PRO n 
1 51  SER n 
1 52  HIS n 
1 53  GLN n 
1 54  TYR n 
1 55  LEU n 
1 56  SER n 
1 57  LEU n 
1 58  THR n 
1 59  LEU n 
1 60  LEU n 
1 61  HIS n 
1 62  LEU n 
1 63  LEU n 
1 64  LYS n 
1 65  ALA n 
1 66  LEU n 
1 67  SER n 
1 68  CYS n 
1 69  GLN n 
1 70  GLU n 
1 71  VAL n 
1 72  THR n 
1 73  ASP n 
1 74  ASP n 
1 75  GLU n 
1 76  VAL n 
1 77  LEU n 
1 78  ASP n 
1 79  ALA n 
1 80  SER n 
1 81  CYS n 
1 82  LEU n 
1 83  LEU n 
1 84  ASP n 
1 85  VAL n 
1 86  LEU n 
1 87  ARG n 
1 88  MET n 
1 89  TYR n 
1 90  ARG n 
1 91  TRP n 
1 92  GLN n 
1 93  ILE n 
1 94  SER n 
1 95  SER n 
1 96  PHE n 
1 97  GLU n 
1 98  GLU n 
1 99  GLN n 
1 100 ASP n 
1 101 ALA n 
1 102 HIS n 
1 103 GLU n 
1 104 LEU n 
1 105 PHE n 
1 106 HIS n 
1 107 VAL n 
1 108 ILE n 
1 109 THR n 
1 110 SER n 
1 111 SER n 
1 112 LEU n 
1 113 GLU n 
1 114 ASP n 
1 115 GLU n 
1 116 ARG n 
1 117 ASP n 
1 118 GLY n 
1 119 SER n 
1 120 GLY n 
1 121 SER n 
1 122 HIS n 
1 123 TRP n 
1 124 LYS n 
1 125 SER n 
1 126 GLN n 
1 127 HIS n 
1 128 PRO n 
1 129 PHE n 
1 130 HIS n 
1 131 GLY n 
1 132 ARG n 
1 133 LEU n 
1 134 THR n 
1 135 SER n 
1 136 ASN n 
1 137 MET n 
1 138 VAL n 
1 139 CYS n 
1 140 LYS n 
1 141 HIS n 
1 142 CYS n 
1 143 GLU n 
1 144 HIS n 
1 145 GLN n 
1 146 SER n 
1 147 PRO n 
1 148 VAL n 
1 149 ARG n 
1 150 PHE n 
1 151 ASP n 
1 152 THR n 
1 153 PHE n 
1 154 ASP n 
1 155 SER n 
1 156 LEU n 
1 157 SER n 
1 158 LEU n 
1 159 SER n 
1 160 ILE n 
1 161 PRO n 
1 162 ALA n 
1 163 ALA n 
1 164 THR n 
1 165 TRP n 
1 166 GLY n 
1 167 HIS n 
1 168 PRO n 
1 169 LEU n 
1 170 THR n 
1 171 LEU n 
1 172 ASP n 
1 173 HIS n 
1 174 CYS n 
1 175 LEU n 
1 176 HIS n 
1 177 HIS n 
1 178 PHE n 
1 179 ILE n 
1 180 SER n 
1 181 SER n 
1 182 GLU n 
1 183 SER n 
1 184 VAL n 
1 185 ARG n 
1 186 ASP n 
1 187 VAL n 
1 188 VAL n 
1 189 CYS n 
1 190 ASP n 
1 191 ASN n 
1 192 CYS n 
1 193 THR n 
1 194 LYS n 
1 195 ILE n 
1 196 GLU n 
1 197 ALA n 
1 198 LYS n 
1 199 GLY n 
1 200 THR n 
1 201 LEU n 
1 202 ASN n 
1 203 GLY n 
1 204 GLU n 
1 205 LYS n 
1 206 VAL n 
1 207 GLU n 
1 208 HIS n 
1 209 GLN n 
1 210 ARG n 
1 211 THR n 
1 212 THR n 
1 213 PHE n 
1 214 VAL n 
1 215 LYS n 
1 216 GLN n 
1 217 LEU n 
1 218 LYS n 
1 219 LEU n 
1 220 GLY n 
1 221 LYS n 
1 222 LEU n 
1 223 PRO n 
1 224 GLN n 
1 225 CYS n 
1 226 LEU n 
1 227 CYS n 
1 228 ILE n 
1 229 HIS n 
1 230 LEU n 
1 231 GLN n 
1 232 ARG n 
1 233 LEU n 
1 234 SER n 
1 235 TRP n 
1 236 SER n 
1 237 SER n 
1 238 HIS n 
1 239 GLY n 
1 240 THR n 
1 241 PRO n 
1 242 LEU n 
1 243 LYS n 
1 244 ARG n 
1 245 HIS n 
1 246 GLU n 
1 247 HIS n 
1 248 VAL n 
1 249 GLN n 
1 250 PHE n 
1 251 ASN n 
1 252 GLU n 
1 253 ASP n 
1 254 LEU n 
1 255 SER n 
1 256 MET n 
1 257 ASP n 
1 258 GLU n 
1 259 TYR n 
1 260 LYS n 
1 261 TYR n 
1 262 HIS n 
1 263 SER n 
1 264 ASN n 
1 265 ALA n 
1 266 SER n 
1 267 THR n 
1 268 TYR n 
1 269 LEU n 
1 270 PHE n 
1 271 ARG n 
1 272 LEU n 
1 273 MET n 
1 274 ALA n 
1 275 VAL n 
1 276 VAL n 
1 277 VAL n 
1 278 HIS n 
1 279 HIS n 
1 280 GLY n 
1 281 ASP n 
1 282 MET n 
1 283 HIS n 
1 284 SER n 
1 285 GLY n 
1 286 HIS n 
1 287 PHE n 
1 288 VAL n 
1 289 THR n 
1 290 TYR n 
1 291 ARG n 
1 292 ARG n 
1 293 SER n 
1 294 PRO n 
1 295 PRO n 
1 296 SER n 
1 297 ALA n 
1 298 ARG n 
1 299 ASN n 
1 300 PRO n 
1 301 LEU n 
1 302 SER n 
1 303 THR n 
1 304 SER n 
1 305 ASN n 
1 306 GLN n 
1 307 TRP n 
1 308 LEU n 
1 309 TRP n 
1 310 VAL n 
1 311 SER n 
1 312 ASP n 
1 313 ASP n 
1 314 THR n 
1 315 VAL n 
1 316 ARG n 
1 317 LYS n 
1 318 ALA n 
1 319 SER n 
1 320 LEU n 
1 321 GLN n 
1 322 GLU n 
1 323 VAL n 
1 324 LEU n 
1 325 SER n 
1 326 SER n 
1 327 SER n 
1 328 ALA n 
1 329 TYR n 
1 330 LEU n 
1 331 LEU n 
1 332 PHE n 
1 333 TYR n 
1 334 GLU n 
1 335 ARG n 
1 336 VAL n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1   117 human ? USP30 ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Escherichia coli' 562 ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
1 2 sample 'Biological sequence' 118 262 human ? USP30 ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Escherichia coli' 562 ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
1 3 sample 'Biological sequence' 263 336 human ? USP30 ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Escherichia coli' 562 ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1L7W non-polymer         . 
'5-(3-cyanophenyl)-~{N}-[[(3~{S})-1-(iminomethyl)pyrrolidin-3-yl]methyl]-1,3,4-oxadiazole-2-carboxamide' ? 'C16 H16 N6 O2'  
324.337 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'     89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'    132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'   121.158 
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'   146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'     75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 
HOH   non-polymer         . WATER ? 'H2 O'           18.015  
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'    131.173 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'    131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'  149.211 
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'    165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'     115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'     105.093 
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'     119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'  204.225 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'    181.189 
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'    117.146 
ZN    non-polymer         . 'ZINC ION' ? 'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   62  ?   ?   ?   A . n 
A 1 2   PRO 2   63  ?   ?   ?   A . n 
A 1 3   LYS 3   64  64  LYS LYS A . n 
A 1 4   GLY 4   65  65  GLY GLY A . n 
A 1 5   LEU 5   66  66  LEU LEU A . n 
A 1 6   VAL 6   67  67  VAL VAL A . n 
A 1 7   PRO 7   68  68  PRO PRO A . n 
A 1 8   GLY 8   69  69  GLY GLY A . n 
A 1 9   LEU 9   70  70  LEU LEU A . n 
A 1 10  VAL 10  71  71  VAL VAL A . n 
A 1 11  ASN 11  72  72  ASN ASN A . n 
A 1 12  LEU 12  73  73  LEU LEU A . n 
A 1 13  GLY 13  74  74  GLY GLY A . n 
A 1 14  ASN 14  75  75  ASN ASN A . n 
A 1 15  THR 15  76  76  THR THR A . n 
A 1 16  CYS 16  77  77  CYS OCS A . n 
A 1 17  PHE 17  78  78  PHE PHE A . n 
A 1 18  MET 18  79  79  MET MET A . n 
A 1 19  ASN 19  80  80  ASN ASN A . n 
A 1 20  SER 20  81  81  SER SER A . n 
A 1 21  LEU 21  82  82  LEU LEU A . n 
A 1 22  LEU 22  83  83  LEU LEU A . n 
A 1 23  GLN 23  84  84  GLN GLN A . n 
A 1 24  GLY 24  85  85  GLY GLY A . n 
A 1 25  LEU 25  86  86  LEU LEU A . n 
A 1 26  SER 26  87  87  SER SER A . n 
A 1 27  ALA 27  88  88  ALA ALA A . n 
A 1 28  CYS 28  89  89  CYS CYS A . n 
A 1 29  PRO 29  90  90  PRO PRO A . n 
A 1 30  ALA 30  91  91  ALA ALA A . n 
A 1 31  PHE 31  92  92  PHE PHE A . n 
A 1 32  ILE 32  93  93  ILE ILE A . n 
A 1 33  ARG 33  94  94  ARG ARG A . n 
A 1 34  TRP 34  95  95  TRP TRP A . n 
A 1 35  LEU 35  96  96  LEU LEU A . n 
A 1 36  GLU 36  97  97  GLU GLU A . n 
A 1 37  GLU 37  98  98  GLU GLU A . n 
A 1 38  PHE 38  99  99  PHE PHE A . n 
A 1 39  THR 39  100 100 THR THR A . n 
A 1 40  SER 40  101 101 SER SER A . n 
A 1 41  GLN 41  102 102 GLN GLN A . n 
A 1 42  TYR 42  103 103 TYR TYR A . n 
A 1 43  SER 43  104 104 SER SER A . n 
A 1 44  ARG 44  105 105 ARG ARG A . n 
A 1 45  ASP 45  106 106 ASP ASP A . n 
A 1 46  GLN 46  107 107 GLN GLN A . n 
A 1 47  LYS 47  108 108 LYS LYS A . n 
A 1 48  GLU 48  109 109 GLU GLU A . n 
A 1 49  PRO 49  110 110 PRO PRO A . n 
A 1 50  PRO 50  111 111 PRO PRO A . n 
A 1 51  SER 51  112 ?   ?   ?   A . n 
A 1 52  HIS 52  113 ?   ?   ?   A . n 
A 1 53  GLN 53  114 114 GLN GLN A . n 
A 1 54  TYR 54  115 115 TYR TYR A . n 
A 1 55  LEU 55  116 116 LEU LEU A . n 
A 1 56  SER 56  117 117 SER SER A . n 
A 1 57  LEU 57  118 118 LEU LEU A . n 
A 1 58  THR 58  119 119 THR THR A . n 
A 1 59  LEU 59  120 120 LEU LEU A . n 
A 1 60  LEU 60  121 121 LEU LEU A . n 
A 1 61  HIS 61  122 122 HIS HIS A . n 
A 1 62  LEU 62  123 123 LEU LEU A . n 
A 1 63  LEU 63  124 124 LEU LEU A . n 
A 1 64  LYS 64  125 125 LYS LYS A . n 
A 1 65  ALA 65  126 126 ALA ALA A . n 
A 1 66  LEU 66  127 127 LEU LEU A . n 
A 1 67  SER 67  128 128 SER SER A . n 
A 1 68  CYS 68  129 129 CYS CYS A . n 
A 1 69  GLN 69  130 130 GLN GLN A . n 
A 1 70  GLU 70  131 131 GLU GLU A . n 
A 1 71  VAL 71  132 132 VAL VAL A . n 
A 1 72  THR 72  133 133 THR THR A . n 
A 1 73  ASP 73  134 134 ASP ASP A . n 
A 1 74  ASP 74  135 135 ASP ASP A . n 
A 1 75  GLU 75  136 136 GLU GLU A . n 
A 1 76  VAL 76  137 137 VAL VAL A . n 
A 1 77  LEU 77  138 138 LEU LEU A . n 
A 1 78  ASP 78  139 139 ASP ASP A . n 
A 1 79  ALA 79  140 140 ALA ALA A . n 
A 1 80  SER 80  141 141 SER SER A . n 
A 1 81  CYS 81  142 142 CYS CYS A . n 
A 1 82  LEU 82  143 143 LEU LEU A . n 
A 1 83  LEU 83  144 144 LEU LEU A . n 
A 1 84  ASP 84  145 145 ASP ASP A . n 
A 1 85  VAL 85  146 146 VAL VAL A . n 
A 1 86  LEU 86  147 147 LEU LEU A . n 
A 1 87  ARG 87  148 148 ARG ARG A . n 
A 1 88  MET 88  149 149 MET MET A . n 
A 1 89  TYR 89  150 150 TYR TYR A . n 
A 1 90  ARG 90  151 ?   ?   ?   A . n 
A 1 91  TRP 91  152 ?   ?   ?   A . n 
A 1 92  GLN 92  153 ?   ?   ?   A . n 
A 1 93  ILE 93  154 ?   ?   ?   A . n 
A 1 94  SER 94  155 ?   ?   ?   A . n 
A 1 95  SER 95  156 ?   ?   ?   A . n 
A 1 96  PHE 96  157 ?   ?   ?   A . n 
A 1 97  GLU 97  158 ?   ?   ?   A . n 
A 1 98  GLU 98  159 ?   ?   ?   A . n 
A 1 99  GLN 99  160 ?   ?   ?   A . n 
A 1 100 ASP 100 161 161 ASP ASP A . n 
A 1 101 ALA 101 162 162 ALA ALA A . n 
A 1 102 HIS 102 163 163 HIS HIS A . n 
A 1 103 GLU 103 164 164 GLU GLU A . n 
A 1 104 LEU 104 165 165 LEU LEU A . n 
A 1 105 PHE 105 166 166 PHE PHE A . n 
A 1 106 HIS 106 167 167 HIS HIS A . n 
A 1 107 VAL 107 168 168 VAL VAL A . n 
A 1 108 ILE 108 169 169 ILE ILE A . n 
A 1 109 THR 109 170 170 THR THR A . n 
A 1 110 SER 110 171 171 SER SER A . n 
A 1 111 SER 111 172 172 SER SER A . n 
A 1 112 LEU 112 173 173 LEU LEU A . n 
A 1 113 GLU 113 174 174 GLU GLU A . n 
A 1 114 ASP 114 175 175 ASP ASP A . n 
A 1 115 GLU 115 176 176 GLU GLU A . n 
A 1 116 ARG 116 177 177 ARG ARG A . n 
A 1 117 ASP 117 178 178 ASP ASP A . n 
A 1 118 GLY 118 213 ?   ?   ?   A . n 
A 1 119 SER 119 214 ?   ?   ?   A . n 
A 1 120 GLY 120 215 ?   ?   ?   A . n 
A 1 121 SER 121 216 ?   ?   ?   A . n 
A 1 122 HIS 122 217 ?   ?   ?   A . n 
A 1 123 TRP 123 218 ?   ?   ?   A . n 
A 1 124 LYS 124 219 219 LYS LYS A . n 
A 1 125 SER 125 220 220 SER SER A . n 
A 1 126 GLN 126 221 221 GLN GLN A . n 
A 1 127 HIS 127 222 222 HIS HIS A . n 
A 1 128 PRO 128 223 223 PRO PRO A . n 
A 1 129 PHE 129 224 224 PHE PHE A . n 
A 1 130 HIS 130 225 225 HIS HIS A . n 
A 1 131 GLY 131 226 226 GLY GLY A . n 
A 1 132 ARG 132 227 227 ARG ARG A . n 
A 1 133 LEU 133 228 228 LEU LEU A . n 
A 1 134 THR 134 229 229 THR THR A . n 
A 1 135 SER 135 230 230 SER SER A . n 
A 1 136 ASN 136 231 231 ASN ASN A . n 
A 1 137 MET 137 232 232 MET MET A . n 
A 1 138 VAL 138 233 233 VAL VAL A . n 
A 1 139 CYS 139 234 234 CYS CYS A . n 
A 1 140 LYS 140 235 235 LYS LYS A . n 
A 1 141 HIS 141 236 236 HIS HIS A . n 
A 1 142 CYS 142 237 237 CYS CYS A . n 
A 1 143 GLU 143 238 238 GLU GLU A . n 
A 1 144 HIS 144 239 239 HIS HIS A . n 
A 1 145 GLN 145 240 240 GLN GLN A . n 
A 1 146 SER 146 241 241 SER SER A . n 
A 1 147 PRO 147 242 242 PRO PRO A . n 
A 1 148 VAL 148 243 243 VAL VAL A . n 
A 1 149 ARG 149 244 244 ARG ARG A . n 
A 1 150 PHE 150 245 245 PHE PHE A . n 
A 1 151 ASP 151 246 246 ASP ASP A . n 
A 1 152 THR 152 247 247 THR THR A . n 
A 1 153 PHE 153 248 248 PHE PHE A . n 
A 1 154 ASP 154 249 249 ASP ASP A . n 
A 1 155 SER 155 250 250 SER SER A . n 
A 1 156 LEU 156 251 251 LEU LEU A . n 
A 1 157 SER 157 252 252 SER SER A . n 
A 1 158 LEU 158 253 253 LEU LEU A . n 
A 1 159 SER 159 254 254 SER SER A . n 
A 1 160 ILE 160 255 255 ILE ILE A . n 
A 1 161 PRO 161 256 256 PRO PRO A . n 
A 1 162 ALA 162 257 257 ALA ALA A . n 
A 1 163 ALA 163 258 258 ALA ALA A . n 
A 1 164 THR 164 259 259 THR THR A . n 
A 1 165 TRP 165 260 260 TRP TRP A . n 
A 1 166 GLY 166 261 261 GLY GLY A . n 
A 1 167 HIS 167 262 262 HIS HIS A . n 
A 1 168 PRO 168 263 263 PRO PRO A . n 
A 1 169 LEU 169 264 264 LEU LEU A . n 
A 1 170 THR 170 265 265 THR THR A . n 
A 1 171 LEU 171 266 266 LEU LEU A . n 
A 1 172 ASP 172 267 267 ASP ASP A . n 
A 1 173 HIS 173 268 268 HIS HIS A . n 
A 1 174 CYS 174 269 269 CYS CYS A . n 
A 1 175 LEU 175 270 270 LEU LEU A . n 
A 1 176 HIS 176 271 271 HIS HIS A . n 
A 1 177 HIS 177 272 272 HIS HIS A . n 
A 1 178 PHE 178 273 273 PHE PHE A . n 
A 1 179 ILE 179 274 274 ILE ILE A . n 
A 1 180 SER 180 275 275 SER SER A . n 
A 1 181 SER 181 276 276 SER SER A . n 
A 1 182 GLU 182 277 277 GLU GLU A . n 
A 1 183 SER 183 278 278 SER SER A . n 
A 1 184 VAL 184 279 279 VAL VAL A . n 
A 1 185 ARG 185 280 280 ARG ARG A . n 
A 1 186 ASP 186 281 281 ASP ASP A . n 
A 1 187 VAL 187 282 282 VAL VAL A . n 
A 1 188 VAL 188 283 283 VAL VAL A . n 
A 1 189 CYS 189 284 284 CYS CYS A . n 
A 1 190 ASP 190 285 285 ASP ASP A . n 
A 1 191 ASN 191 286 286 ASN ASN A . n 
A 1 192 CYS 192 287 287 CYS CYS A . n 
A 1 193 THR 193 288 288 THR THR A . n 
A 1 194 LYS 194 289 289 LYS LYS A . n 
A 1 195 ILE 195 290 290 ILE ILE A . n 
A 1 196 GLU 196 291 291 GLU GLU A . n 
A 1 197 ALA 197 292 292 ALA ALA A . n 
A 1 198 LYS 198 293 293 LYS LYS A . n 
A 1 199 GLY 199 294 ?   ?   ?   A . n 
A 1 200 THR 200 295 ?   ?   ?   A . n 
A 1 201 LEU 201 296 ?   ?   ?   A . n 
A 1 202 ASN 202 297 ?   ?   ?   A . n 
A 1 203 GLY 203 298 298 GLY GLY A . n 
A 1 204 GLU 204 299 299 GLU GLU A . n 
A 1 205 LYS 205 300 300 LYS LYS A . n 
A 1 206 VAL 206 301 301 VAL VAL A . n 
A 1 207 GLU 207 302 302 GLU GLU A . n 
A 1 208 HIS 208 303 303 HIS HIS A . n 
A 1 209 GLN 209 304 304 GLN GLN A . n 
A 1 210 ARG 210 305 305 ARG ARG A . n 
A 1 211 THR 211 306 306 THR THR A . n 
A 1 212 THR 212 307 307 THR THR A . n 
A 1 213 PHE 213 308 308 PHE PHE A . n 
A 1 214 VAL 214 309 309 VAL VAL A . n 
A 1 215 LYS 215 310 310 LYS LYS A . n 
A 1 216 GLN 216 311 311 GLN GLN A . n 
A 1 217 LEU 217 312 312 LEU LEU A . n 
A 1 218 LYS 218 313 313 LYS LYS A . n 
A 1 219 LEU 219 314 314 LEU LEU A . n 
A 1 220 GLY 220 315 315 GLY GLY A . n 
A 1 221 LYS 221 316 316 LYS LYS A . n 
A 1 222 LEU 222 317 317 LEU LEU A . n 
A 1 223 PRO 223 318 318 PRO PRO A . n 
A 1 224 GLN 224 319 319 GLN GLN A . n 
A 1 225 CYS 225 320 320 CYS CYS A . n 
A 1 226 LEU 226 321 321 LEU LEU A . n 
A 1 227 CYS 227 322 322 CYS CYS A . n 
A 1 228 ILE 228 323 323 ILE ILE A . n 
A 1 229 HIS 229 324 324 HIS HIS A . n 
A 1 230 LEU 230 325 325 LEU LEU A . n 
A 1 231 GLN 231 326 326 GLN GLN A . n 
A 1 232 ARG 232 327 327 ARG ARG A . n 
A 1 233 LEU 233 328 328 LEU LEU A . n 
A 1 234 SER 234 329 329 SER SER A . n 
A 1 235 TRP 235 330 330 TRP TRP A . n 
A 1 236 SER 236 331 331 SER SER A . n 
A 1 237 SER 237 332 332 SER SER A . n 
A 1 238 HIS 238 333 333 HIS HIS A . n 
A 1 239 GLY 239 334 334 GLY GLY A . n 
A 1 240 THR 240 335 335 THR THR A . n 
A 1 241 PRO 241 336 336 PRO PRO A . n 
A 1 242 LEU 242 337 337 LEU LEU A . n 
A 1 243 LYS 243 338 338 LYS LYS A . n 
A 1 244 ARG 244 339 339 ARG ARG A . n 
A 1 245 HIS 245 340 340 HIS HIS A . n 
A 1 246 GLU 246 341 341 GLU GLU A . n 
A 1 247 HIS 247 342 342 HIS HIS A . n 
A 1 248 VAL 248 343 343 VAL VAL A . n 
A 1 249 GLN 249 344 344 GLN GLN A . n 
A 1 250 PHE 250 345 345 PHE PHE A . n 
A 1 251 ASN 251 346 346 ASN ASN A . n 
A 1 252 GLU 252 347 347 GLU GLU A . n 
A 1 253 ASP 253 348 348 ASP ASP A . n 
A 1 254 LEU 254 349 349 LEU LEU A . n 
A 1 255 SER 255 350 350 SER SER A . n 
A 1 256 MET 256 351 351 MET MET A . n 
A 1 257 ASP 257 352 352 ASP ASP A . n 
A 1 258 GLU 258 353 353 GLU GLU A . n 
A 1 259 TYR 259 354 354 TYR TYR A . n 
A 1 260 LYS 260 355 355 LYS LYS A . n 
A 1 261 TYR 261 427 ?   ?   ?   A . n 
A 1 262 HIS 262 428 ?   ?   ?   A . n 
A 1 263 SER 263 429 ?   ?   ?   A . n 
A 1 264 ASN 264 430 ?   ?   ?   A . n 
A 1 265 ALA 265 431 ?   ?   ?   A . n 
A 1 266 SER 266 432 ?   ?   ?   A . n 
A 1 267 THR 267 433 ?   ?   ?   A . n 
A 1 268 TYR 268 434 ?   ?   ?   A . n 
A 1 269 LEU 269 435 435 LEU LEU A . n 
A 1 270 PHE 270 436 436 PHE PHE A . n 
A 1 271 ARG 271 437 437 ARG ARG A . n 
A 1 272 LEU 272 438 438 LEU LEU A . n 
A 1 273 MET 273 439 439 MET MET A . n 
A 1 274 ALA 274 440 440 ALA ALA A . n 
A 1 275 VAL 275 441 441 VAL VAL A . n 
A 1 276 VAL 276 442 442 VAL VAL A . n 
A 1 277 VAL 277 443 443 VAL VAL A . n 
A 1 278 HIS 278 444 444 HIS HIS A . n 
A 1 279 HIS 279 445 445 HIS HIS A . n 
A 1 280 GLY 280 446 446 GLY GLY A . n 
A 1 281 ASP 281 447 447 ASP ASP A . n 
A 1 282 MET 282 448 448 MET MET A . n 
A 1 283 HIS 283 449 449 HIS HIS A . n 
A 1 284 SER 284 450 450 SER SER A . n 
A 1 285 GLY 285 451 451 GLY GLY A . n 
A 1 286 HIS 286 452 452 HIS HIS A . n 
A 1 287 PHE 287 453 453 PHE PHE A . n 
A 1 288 VAL 288 454 454 VAL VAL A . n 
A 1 289 THR 289 455 455 THR THR A . n 
A 1 290 TYR 290 456 456 TYR TYR A . n 
A 1 291 ARG 291 457 457 ARG ARG A . n 
A 1 292 ARG 292 458 458 ARG ARG A . n 
A 1 293 SER 293 459 459 SER SER A . n 
A 1 294 PRO 294 460 460 PRO PRO A . n 
A 1 295 PRO 295 461 461 PRO PRO A . n 
A 1 296 SER 296 462 462 SER SER A . n 
A 1 297 ALA 297 463 ?   ?   ?   A . n 
A 1 298 ARG 298 464 ?   ?   ?   A . n 
A 1 299 ASN 299 465 ?   ?   ?   A . n 
A 1 300 PRO 300 466 466 PRO PRO A . n 
A 1 301 LEU 301 467 467 LEU LEU A . n 
A 1 302 SER 302 468 468 SER SER A . n 
A 1 303 THR 303 469 469 THR THR A . n 
A 1 304 SER 304 470 470 SER SER A . n 
A 1 305 ASN 305 471 471 ASN ASN A . n 
A 1 306 GLN 306 472 472 GLN GLN A . n 
A 1 307 TRP 307 473 473 TRP TRP A . n 
A 1 308 LEU 308 474 474 LEU LEU A . n 
A 1 309 TRP 309 475 475 TRP TRP A . n 
A 1 310 VAL 310 476 476 VAL VAL A . n 
A 1 311 SER 311 477 477 SER SER A . n 
A 1 312 ASP 312 478 478 ASP ASP A . n 
A 1 313 ASP 313 479 479 ASP ASP A . n 
A 1 314 THR 314 480 480 THR THR A . n 
A 1 315 VAL 315 481 481 VAL VAL A . n 
A 1 316 ARG 316 482 482 ARG ARG A . n 
A 1 317 LYS 317 483 483 LYS LYS A . n 
A 1 318 ALA 318 484 484 ALA ALA A . n 
A 1 319 SER 319 485 485 SER SER A . n 
A 1 320 LEU 320 486 486 LEU LEU A . n 
A 1 321 GLN 321 487 487 GLN GLN A . n 
A 1 322 GLU 322 488 488 GLU GLU A . n 
A 1 323 VAL 323 489 489 VAL VAL A . n 
A 1 324 LEU 324 490 490 LEU LEU A . n 
A 1 325 SER 325 491 491 SER SER A . n 
A 1 326 SER 326 492 492 SER SER A . n 
A 1 327 SER 327 493 493 SER SER A . n 
A 1 328 ALA 328 494 494 ALA ALA A . n 
A 1 329 TYR 329 495 495 TYR TYR A . n 
A 1 330 LEU 330 496 496 LEU LEU A . n 
A 1 331 LEU 331 497 497 LEU LEU A . n 
A 1 332 PHE 332 498 498 PHE PHE A . n 
A 1 333 TYR 333 499 499 TYR TYR A . n 
A 1 334 GLU 334 500 500 GLU GLU A . n 
A 1 335 ARG 335 501 501 ARG ARG A . n 
A 1 336 VAL 336 502 502 VAL VAL A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1L7W 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1L7W 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 A1L7W 1  601 77 A1L7W OCS A . 
C 3 ZN    1  602 1  ZN    ZN  A . 
D 4 HOH   1  701 5  HOH   HOH A . 
D 4 HOH   2  702 12 HOH   HOH A . 
D 4 HOH   3  703 1  HOH   HOH A . 
D 4 HOH   4  704 4  HOH   HOH A . 
D 4 HOH   5  705 15 HOH   HOH A . 
D 4 HOH   6  706 3  HOH   HOH A . 
D 4 HOH   7  707 6  HOH   HOH A . 
D 4 HOH   8  708 14 HOH   HOH A . 
D 4 HOH   9  709 9  HOH   HOH A . 
D 4 HOH   10 710 13 HOH   HOH A . 
D 4 HOH   11 711 8  HOH   HOH A . 
D 4 HOH   12 712 2  HOH   HOH A . 
D 4 HOH   13 713 7  HOH   HOH A . 
D 4 HOH   14 714 11 HOH   HOH A . 
D 4 HOH   15 715 16 HOH   HOH A . 
D 4 HOH   16 716 10 HOH   HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1   1 Y 1 A LYS 64  ? CD  ? A LYS 3   CD  
2   1 Y 1 A LYS 64  ? CE  ? A LYS 3   CE  
3   1 Y 1 A LYS 64  ? NZ  ? A LYS 3   NZ  
4   1 Y 1 A ASN 75  ? CG  ? A ASN 14  CG  
5   1 Y 1 A ASN 75  ? OD1 ? A ASN 14  OD1 
6   1 Y 1 A ASN 75  ? ND2 ? A ASN 14  ND2 
7   1 Y 1 A SER 104 ? OG  ? A SER 43  OG  
8   1 Y 1 A ARG 105 ? CG  ? A ARG 44  CG  
9   1 Y 1 A ARG 105 ? CD  ? A ARG 44  CD  
10  1 Y 1 A ARG 105 ? NE  ? A ARG 44  NE  
11  1 Y 1 A ARG 105 ? CZ  ? A ARG 44  CZ  
12  1 Y 1 A ARG 105 ? NH1 ? A ARG 44  NH1 
13  1 Y 1 A ARG 105 ? NH2 ? A ARG 44  NH2 
14  1 Y 1 A ASP 106 ? CG  ? A ASP 45  CG  
15  1 Y 1 A ASP 106 ? OD1 ? A ASP 45  OD1 
16  1 Y 1 A ASP 106 ? OD2 ? A ASP 45  OD2 
17  1 Y 1 A GLN 107 ? CG  ? A GLN 46  CG  
18  1 Y 1 A GLN 107 ? CD  ? A GLN 46  CD  
19  1 Y 1 A GLN 107 ? OE1 ? A GLN 46  OE1 
20  1 Y 1 A GLN 107 ? NE2 ? A GLN 46  NE2 
21  1 Y 1 A LYS 108 ? CG  ? A LYS 47  CG  
22  1 Y 1 A LYS 108 ? CD  ? A LYS 47  CD  
23  1 Y 1 A LYS 108 ? CE  ? A LYS 47  CE  
24  1 Y 1 A LYS 108 ? NZ  ? A LYS 47  NZ  
25  1 Y 1 A GLU 109 ? CG  ? A GLU 48  CG  
26  1 Y 1 A GLU 109 ? CD  ? A GLU 48  CD  
27  1 Y 1 A GLU 109 ? OE1 ? A GLU 48  OE1 
28  1 Y 1 A GLU 109 ? OE2 ? A GLU 48  OE2 
29  1 Y 1 A GLN 114 ? CG  ? A GLN 53  CG  
30  1 Y 1 A GLN 114 ? CD  ? A GLN 53  CD  
31  1 Y 1 A GLN 114 ? OE1 ? A GLN 53  OE1 
32  1 Y 1 A GLN 114 ? NE2 ? A GLN 53  NE2 
33  1 Y 1 A TYR 115 ? CG  ? A TYR 54  CG  
34  1 Y 1 A TYR 115 ? CD1 ? A TYR 54  CD1 
35  1 Y 1 A TYR 115 ? CD2 ? A TYR 54  CD2 
36  1 Y 1 A TYR 115 ? CE1 ? A TYR 54  CE1 
37  1 Y 1 A TYR 115 ? CE2 ? A TYR 54  CE2 
38  1 Y 1 A TYR 115 ? CZ  ? A TYR 54  CZ  
39  1 Y 1 A TYR 115 ? OH  ? A TYR 54  OH  
40  1 Y 1 A LYS 125 ? CG  ? A LYS 64  CG  
41  1 Y 1 A LYS 125 ? CD  ? A LYS 64  CD  
42  1 Y 1 A LYS 125 ? CE  ? A LYS 64  CE  
43  1 Y 1 A LYS 125 ? NZ  ? A LYS 64  NZ  
44  1 Y 1 A GLU 131 ? CG  ? A GLU 70  CG  
45  1 Y 1 A GLU 131 ? CD  ? A GLU 70  CD  
46  1 Y 1 A GLU 131 ? OE1 ? A GLU 70  OE1 
47  1 Y 1 A GLU 131 ? OE2 ? A GLU 70  OE2 
48  1 Y 1 A ARG 148 ? CG  ? A ARG 87  CG  
49  1 Y 1 A ARG 148 ? CD  ? A ARG 87  CD  
50  1 Y 1 A ARG 148 ? NE  ? A ARG 87  NE  
51  1 Y 1 A ARG 148 ? CZ  ? A ARG 87  CZ  
52  1 Y 1 A ARG 148 ? NH1 ? A ARG 87  NH1 
53  1 Y 1 A ARG 148 ? NH2 ? A ARG 87  NH2 
54  1 Y 1 A TYR 150 ? CG  ? A TYR 89  CG  
55  1 Y 1 A TYR 150 ? CD1 ? A TYR 89  CD1 
56  1 Y 1 A TYR 150 ? CD2 ? A TYR 89  CD2 
57  1 Y 1 A TYR 150 ? CE1 ? A TYR 89  CE1 
58  1 Y 1 A TYR 150 ? CE2 ? A TYR 89  CE2 
59  1 Y 1 A TYR 150 ? CZ  ? A TYR 89  CZ  
60  1 Y 1 A TYR 150 ? OH  ? A TYR 89  OH  
61  1 Y 1 A GLU 174 ? CG  ? A GLU 113 CG  
62  1 Y 1 A GLU 174 ? CD  ? A GLU 113 CD  
63  1 Y 1 A GLU 174 ? OE1 ? A GLU 113 OE1 
64  1 Y 1 A GLU 174 ? OE2 ? A GLU 113 OE2 
65  1 Y 1 A LYS 219 ? CG  ? A LYS 124 CG  
66  1 Y 1 A LYS 219 ? CD  ? A LYS 124 CD  
67  1 Y 1 A LYS 219 ? CE  ? A LYS 124 CE  
68  1 Y 1 A LYS 219 ? NZ  ? A LYS 124 NZ  
69  1 Y 1 A LYS 235 ? CG  ? A LYS 140 CG  
70  1 Y 1 A LYS 235 ? CD  ? A LYS 140 CD  
71  1 Y 1 A LYS 235 ? CE  ? A LYS 140 CE  
72  1 Y 1 A LYS 235 ? NZ  ? A LYS 140 NZ  
73  1 Y 1 A SER 241 ? OG  ? A SER 146 OG  
74  1 Y 1 A THR 259 ? OG1 ? A THR 164 OG1 
75  1 Y 1 A THR 259 ? CG2 ? A THR 164 CG2 
76  1 Y 1 A TRP 260 ? CG  ? A TRP 165 CG  
77  1 Y 1 A TRP 260 ? CD1 ? A TRP 165 CD1 
78  1 Y 1 A TRP 260 ? CD2 ? A TRP 165 CD2 
79  1 Y 1 A TRP 260 ? NE1 ? A TRP 165 NE1 
80  1 Y 1 A TRP 260 ? CE2 ? A TRP 165 CE2 
81  1 Y 1 A TRP 260 ? CE3 ? A TRP 165 CE3 
82  1 Y 1 A TRP 260 ? CZ2 ? A TRP 165 CZ2 
83  1 Y 1 A TRP 260 ? CZ3 ? A TRP 165 CZ3 
84  1 Y 1 A TRP 260 ? CH2 ? A TRP 165 CH2 
85  1 Y 1 A HIS 268 ? CG  ? A HIS 173 CG  
86  1 Y 1 A HIS 268 ? ND1 ? A HIS 173 ND1 
87  1 Y 1 A HIS 268 ? CD2 ? A HIS 173 CD2 
88  1 Y 1 A HIS 268 ? CE1 ? A HIS 173 CE1 
89  1 Y 1 A HIS 268 ? NE2 ? A HIS 173 NE2 
90  1 Y 1 A SER 276 ? OG  ? A SER 181 OG  
91  1 Y 1 A GLU 277 ? CG  ? A GLU 182 CG  
92  1 Y 1 A GLU 277 ? CD  ? A GLU 182 CD  
93  1 Y 1 A GLU 277 ? OE1 ? A GLU 182 OE1 
94  1 Y 1 A GLU 277 ? OE2 ? A GLU 182 OE2 
95  1 Y 1 A ASP 281 ? CG  ? A ASP 186 CG  
96  1 Y 1 A ASP 281 ? OD1 ? A ASP 186 OD1 
97  1 Y 1 A ASP 281 ? OD2 ? A ASP 186 OD2 
98  1 Y 1 A ASP 285 ? CG  ? A ASP 190 CG  
99  1 Y 1 A ASP 285 ? OD1 ? A ASP 190 OD1 
100 1 Y 1 A ASP 285 ? OD2 ? A ASP 190 OD2 
101 1 Y 1 A LYS 293 ? CG  ? A LYS 198 CG  
102 1 Y 1 A LYS 293 ? CD  ? A LYS 198 CD  
103 1 Y 1 A LYS 293 ? CE  ? A LYS 198 CE  
104 1 Y 1 A LYS 293 ? NZ  ? A LYS 198 NZ  
105 1 Y 1 A GLU 299 ? CG  ? A GLU 204 CG  
106 1 Y 1 A GLU 299 ? CD  ? A GLU 204 CD  
107 1 Y 1 A GLU 299 ? OE1 ? A GLU 204 OE1 
108 1 Y 1 A GLU 299 ? OE2 ? A GLU 204 OE2 
109 1 Y 1 A LYS 300 ? CG  ? A LYS 205 CG  
110 1 Y 1 A LYS 300 ? CD  ? A LYS 205 CD  
111 1 Y 1 A LYS 300 ? CE  ? A LYS 205 CE  
112 1 Y 1 A LYS 300 ? NZ  ? A LYS 205 NZ  
113 1 Y 1 A VAL 301 ? CG1 ? A VAL 206 CG1 
114 1 Y 1 A VAL 301 ? CG2 ? A VAL 206 CG2 
115 1 Y 1 A GLU 302 ? CG  ? A GLU 207 CG  
116 1 Y 1 A GLU 302 ? CD  ? A GLU 207 CD  
117 1 Y 1 A GLU 302 ? OE1 ? A GLU 207 OE1 
118 1 Y 1 A GLU 302 ? OE2 ? A GLU 207 OE2 
119 1 Y 1 A GLN 304 ? CG  ? A GLN 209 CG  
120 1 Y 1 A GLN 304 ? CD  ? A GLN 209 CD  
121 1 Y 1 A GLN 304 ? OE1 ? A GLN 209 OE1 
122 1 Y 1 A GLN 304 ? NE2 ? A GLN 209 NE2 
123 1 Y 1 A LYS 310 ? CG  ? A LYS 215 CG  
124 1 Y 1 A LYS 310 ? CD  ? A LYS 215 CD  
125 1 Y 1 A LYS 310 ? CE  ? A LYS 215 CE  
126 1 Y 1 A LYS 310 ? NZ  ? A LYS 215 NZ  
127 1 Y 1 A LYS 313 ? CE  ? A LYS 218 CE  
128 1 Y 1 A LYS 313 ? NZ  ? A LYS 218 NZ  
129 1 Y 1 A LYS 316 ? CG  ? A LYS 221 CG  
130 1 Y 1 A LYS 316 ? CD  ? A LYS 221 CD  
131 1 Y 1 A LYS 316 ? CE  ? A LYS 221 CE  
132 1 Y 1 A LYS 316 ? NZ  ? A LYS 221 NZ  
133 1 Y 1 A SER 332 ? OG  ? A SER 237 OG  
134 1 Y 1 A GLU 341 ? CG  ? A GLU 246 CG  
135 1 Y 1 A GLU 341 ? CD  ? A GLU 246 CD  
136 1 Y 1 A GLU 341 ? OE1 ? A GLU 246 OE1 
137 1 Y 1 A GLU 341 ? OE2 ? A GLU 246 OE2 
138 1 Y 1 A GLN 344 ? CG  ? A GLN 249 CG  
139 1 Y 1 A GLN 344 ? CD  ? A GLN 249 CD  
140 1 Y 1 A GLN 344 ? OE1 ? A GLN 249 OE1 
141 1 Y 1 A GLN 344 ? NE2 ? A GLN 249 NE2 
142 1 Y 1 A SER 350 ? OG  ? A SER 255 OG  
143 1 Y 1 A GLU 353 ? CG  ? A GLU 258 CG  
144 1 Y 1 A GLU 353 ? CD  ? A GLU 258 CD  
145 1 Y 1 A GLU 353 ? OE1 ? A GLU 258 OE1 
146 1 Y 1 A GLU 353 ? OE2 ? A GLU 258 OE2 
147 1 Y 1 A LYS 355 ? CE  ? A LYS 260 CE  
148 1 Y 1 A LYS 355 ? NZ  ? A LYS 260 NZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? '(1.14_3260: ???)' 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .                  2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .                  3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .                  4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9LYF 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     53.007 
_cell.length_a_esd                 ? 
_cell.length_b                     60.881 
_cell.length_b_esd                 ? 
_cell.length_c                     102.507 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9LYF 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9LYF 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.13 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          42.22 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2M Ammonium citrate tribasic pH 7.0, 20% w/v Polyethylene glycol 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     CCD 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'ADSC QUANTUM 315r' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-11-10 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.95373 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'AUSTRALIAN SYNCHROTRON BEAMLINE MX2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.95373 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   MX2 
_diffrn_source.pdbx_synchrotron_site       'Australian Synchrotron' 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9LYF 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.58 
_reflns.d_resolution_low                               47.08 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     10967 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.5 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                5.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          6.1 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               0.45 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.243 
_reflns.pdbx_Rpim_I_all                                0.103 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       59144 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.990 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.220 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.58 
_reflns_shell.d_res_low                                     2.69 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           7123 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1275 
_reflns_shell.percent_possible_obs                          96.4 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               5.6 
_reflns_shell.pdbx_chi_squared                              0.36 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     1.0 
_reflns_shell.pdbx_Rrim_I_all                               1.554 
_reflns_shell.pdbx_Rpim_I_all                               0.642 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.464 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.410 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9LYF 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.58 
_refine.ls_d_res_low                             47.08 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     10909 
_refine.ls_number_reflns_R_free                  1092 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.45 
_refine.ls_percent_reflns_R_free                 10.01 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2268 
_refine.ls_R_factor_R_free                       0.2724 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2216 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.correlation_coeff_I_to_Fcsqd_work        ? 
_refine.correlation_coeff_I_to_Fcsqd_free        ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 27.98 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.40 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        2299 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         1 
_refine_hist.number_atoms_solvent             16 
_refine_hist.number_atoms_total               2316 
_refine_hist.d_res_high                       2.58 
_refine_hist.d_res_low                        47.08 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.005 ? 2353 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.727 ? 3198 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 5.043 ? 1377 ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.043 ? 375  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.005 ? 404  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.correlation_coeff_Fo_to_Fc 
_refine_ls_shell.correlation_coeff_Fo_to_Fc_free 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_work 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_free 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.58   2.6959 . . 130 1173 97.00  . . . . 0.3044 . . . . . . . . . . . . . . . 0.3639 
'X-RAY DIFFRACTION' 2.6959 2.8380 . . 135 1210 100.00 . . . . 0.2787 . . . . . . . . . . . . . . . 0.3354 
'X-RAY DIFFRACTION' 2.8380 3.0158 . . 135 1211 100.00 . . . . 0.2538 . . . . . . . . . . . . . . . 0.3330 
'X-RAY DIFFRACTION' 3.0158 3.2486 . . 134 1208 100.00 . . . . 0.2550 . . . . . . . . . . . . . . . 0.2989 
'X-RAY DIFFRACTION' 3.2486 3.5754 . . 135 1215 100.00 . . . . 0.2116 . . . . . . . . . . . . . . . 0.2865 
'X-RAY DIFFRACTION' 3.5754 4.0925 . . 138 1243 100.00 . . . . 0.2072 . . . . . . . . . . . . . . . 0.2563 
'X-RAY DIFFRACTION' 4.0925 5.1551 . . 138 1232 100.00 . . . . 0.1756 . . . . . . . . . . . . . . . 0.2386 
'X-RAY DIFFRACTION' 5.1551 47.08  . . 147 1325 100.00 . . . . 0.2240 . . . . . . . . . . . . . . . 0.2406 
# 
_struct.entry_id                     9LYF 
_struct.title                        'Structure-based Discovery of Novel non-Covalent Small Molecule Inhibitors of USP30' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9LYF 
_struct_keywords.text            
'USP30, deubiquitination, covalent small molecule inhibitor, non-Covalent Small Molecule Inhibitors, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP UBP30_HUMAN Q70CQ3 ? 1 
;KGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCL
LDVLRMYRWQISSFEEQDAHELFHVITSSLEDERD
;
64  
2 UNP UBP30_HUMAN Q70CQ3 ? 1 
;HWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTL
NGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYH
;
217 
3 UNP UBP30_HUMAN Q70CQ3 ? 1 STYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERV 432 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9LYF A 3   ? 117 ? Q70CQ3 64  ? 178 ? 64  178 
2 2 9LYF A 122 ? 262 ? Q70CQ3 217 ? 357 ? 217 428 
3 3 9LYF A 266 ? 336 ? Q70CQ3 432 ? 502 ? 432 502 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9LYF GLY A 1   ? UNP Q70CQ3 ?   ?   'expression tag'      62  1  
1 9LYF PRO A 2   ? UNP Q70CQ3 ?   ?   'expression tag'      63  2  
1 9LYF GLY A 118 ? UNP Q70CQ3 ?   ?   linker                213 3  
1 9LYF SER A 119 ? UNP Q70CQ3 ?   ?   linker                214 4  
1 9LYF GLY A 120 ? UNP Q70CQ3 ?   ?   linker                215 5  
1 9LYF SER A 121 ? UNP Q70CQ3 ?   ?   linker                216 6  
2 9LYF ASP A 253 ? UNP Q70CQ3 PHE 348 'engineered mutation' 348 7  
2 9LYF SER A 255 ? UNP Q70CQ3 MET 350 'engineered mutation' 350 8  
2 9LYF GLU A 258 ? UNP Q70CQ3 ILE 353 'engineered mutation' 353 9  
2 9LYF SER A 263 ? UNP Q70CQ3 ?   ?   linker                429 10 
2 9LYF ASN A 264 ? UNP Q70CQ3 ?   ?   linker                430 11 
2 9LYF ALA A 265 ? UNP Q70CQ3 ?   ?   linker                431 12 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 THR A 15  ? SER A 26  ? THR A 76  SER A 87  1 ? 12 
HELX_P HELX_P2 AA2 CYS A 28  ? SER A 40  ? CYS A 89  SER A 101 1 ? 13 
HELX_P HELX_P3 AA3 TYR A 54  ? SER A 67  ? TYR A 115 SER A 128 1 ? 14 
HELX_P HELX_P4 AA4 ALA A 79  ? TYR A 89  ? ALA A 140 TYR A 150 1 ? 11 
HELX_P HELX_P5 AA5 ALA A 101 ? ASP A 117 ? ALA A 162 ASP A 178 1 ? 17 
HELX_P HELX_P6 AA6 THR A 170 ? SER A 181 ? THR A 265 SER A 276 1 ? 12 
HELX_P HELX_P7 AA7 CYS A 189 ? ALA A 197 ? CYS A 284 ALA A 292 1 ? 9  
HELX_P HELX_P8 AA8 MET A 256 ? LYS A 260 ? MET A 351 LYS A 355 5 ? 5  
HELX_P HELX_P9 AA9 SER A 319 ? SER A 325 ? SER A 485 SER A 491 1 ? 7  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale none ? A CYS 16  SG ? ? ? 1_555 B A1L7W . C09 ? ? A CYS 77  A A1L7W 601 1_555 ? ? ? ? ? ? ? 1.887 ? ? 
metalc1 metalc ?    ? A CYS 139 SG ? ? ? 1_555 C ZN    . ZN  ? ? A CYS 234 A ZN    602 1_555 ? ? ? ? ? ? ? 2.351 ? ? 
metalc2 metalc ?    ? A CYS 142 SG ? ? ? 1_555 C ZN    . ZN  ? ? A CYS 237 A ZN    602 1_555 ? ? ? ? ? ? ? 2.386 ? ? 
metalc3 metalc ?    ? A CYS 189 SG ? ? ? 1_555 C ZN    . ZN  ? ? A CYS 284 A ZN    602 1_555 ? ? ? ? ? ? ? 2.307 ? ? 
metalc4 metalc ?    ? A CYS 192 SG ? ? ? 1_555 C ZN    . ZN  ? ? A CYS 287 A ZN    602 1_555 ? ? ? ? ? ? ? 2.553 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
covale ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1 SG ? A CYS 139 ? A CYS 234 ? 1_555 ZN ? C ZN . ? A ZN 602 ? 1_555 SG ? A CYS 142 ? A CYS 237 ? 1_555 102.4 ? 
2 SG ? A CYS 139 ? A CYS 234 ? 1_555 ZN ? C ZN . ? A ZN 602 ? 1_555 SG ? A CYS 189 ? A CYS 284 ? 1_555 116.6 ? 
3 SG ? A CYS 142 ? A CYS 237 ? 1_555 ZN ? C ZN . ? A ZN 602 ? 1_555 SG ? A CYS 189 ? A CYS 284 ? 1_555 102.7 ? 
4 SG ? A CYS 139 ? A CYS 234 ? 1_555 ZN ? C ZN . ? A ZN 602 ? 1_555 SG ? A CYS 192 ? A CYS 287 ? 1_555 111.9 ? 
5 SG ? A CYS 142 ? A CYS 237 ? 1_555 ZN ? C ZN . ? A ZN 602 ? 1_555 SG ? A CYS 192 ? A CYS 287 ? 1_555 110.2 ? 
6 SG ? A CYS 189 ? A CYS 284 ? 1_555 ZN ? C ZN . ? A ZN 602 ? 1_555 SG ? A CYS 192 ? A CYS 287 ? 1_555 112.1 ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      A1L7W 
_pdbx_modification_feature.label_asym_id                      B 
_pdbx_modification_feature.label_seq_id                       . 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      16 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       A1L7W 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        601 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       77 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               C09 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                CYS 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        A1L7W 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Covalent chemical modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 4 ? 
AA3 ? 5 ? 
AA4 ? 7 ? 
AA5 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
AA4 1 2 ? parallel      
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA4 5 6 ? anti-parallel 
AA4 6 7 ? anti-parallel 
AA5 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLY A 8   ? LEU A 9   ? GLY A 69  LEU A 70  
AA1 2 VAL A 76  ? LEU A 77  ? VAL A 137 LEU A 138 
AA2 1 ARG A 149 ? PHE A 153 ? ARG A 244 PHE A 248 
AA2 2 GLY A 131 ? CYS A 139 ? GLY A 226 CYS A 234 
AA2 3 PHE A 213 ? LEU A 219 ? PHE A 308 LEU A 314 
AA2 4 GLU A 182 ? VAL A 184 ? GLU A 277 VAL A 279 
AA3 1 LEU A 156 ? LEU A 158 ? LEU A 251 LEU A 253 
AA3 2 CYS A 225 ? LEU A 230 ? CYS A 320 LEU A 325 
AA3 3 ALA A 328 ? ARG A 335 ? ALA A 494 ARG A 501 
AA3 4 PHE A 270 ? HIS A 279 ? PHE A 436 HIS A 445 
AA3 5 ASP A 253 ? LEU A 254 ? ASP A 348 LEU A 349 
AA4 1 LEU A 156 ? LEU A 158 ? LEU A 251 LEU A 253 
AA4 2 CYS A 225 ? LEU A 230 ? CYS A 320 LEU A 325 
AA4 3 ALA A 328 ? ARG A 335 ? ALA A 494 ARG A 501 
AA4 4 PHE A 270 ? HIS A 279 ? PHE A 436 HIS A 445 
AA4 5 HIS A 286 ? ARG A 292 ? HIS A 452 ARG A 458 
AA4 6 TRP A 307 ? SER A 311 ? TRP A 473 SER A 477 
AA4 7 THR A 314 ? ALA A 318 ? THR A 480 ALA A 484 
AA5 1 LEU A 233 ? TRP A 235 ? LEU A 328 TRP A 330 
AA5 2 PRO A 241 ? LYS A 243 ? PRO A 336 LYS A 338 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLY A 8   ? N GLY A 69  O LEU A 77  ? O LEU A 138 
AA2 1 2 O ASP A 151 ? O ASP A 246 N LEU A 133 ? N LEU A 228 
AA2 2 3 N VAL A 138 ? N VAL A 233 O VAL A 214 ? O VAL A 309 
AA2 3 4 O LYS A 215 ? O LYS A 310 N GLU A 182 ? N GLU A 277 
AA3 1 2 N LEU A 158 ? N LEU A 253 O HIS A 229 ? O HIS A 324 
AA3 2 3 N LEU A 226 ? N LEU A 321 O TYR A 333 ? O TYR A 499 
AA3 3 4 O GLU A 334 ? O GLU A 500 N ARG A 271 ? N ARG A 437 
AA3 4 5 O PHE A 270 ? O PHE A 436 N LEU A 254 ? N LEU A 349 
AA4 1 2 N LEU A 158 ? N LEU A 253 O HIS A 229 ? O HIS A 324 
AA4 2 3 N LEU A 226 ? N LEU A 321 O TYR A 333 ? O TYR A 499 
AA4 3 4 O GLU A 334 ? O GLU A 500 N ARG A 271 ? N ARG A 437 
AA4 4 5 N VAL A 277 ? N VAL A 443 O VAL A 288 ? O VAL A 454 
AA4 5 6 N ARG A 291 ? N ARG A 457 O LEU A 308 ? O LEU A 474 
AA4 6 7 N TRP A 309 ? N TRP A 475 O ARG A 316 ? O ARG A 482 
AA5 1 2 N SER A 234 ? N SER A 329 O LEU A 242 ? O LEU A 337 
# 
_pdbx_entry_details.entry_id                   9LYF 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             O 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             THR 
_pdbx_validate_rmsd_angle.auth_seq_id_1              76 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             C 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             THR 
_pdbx_validate_rmsd_angle.auth_seq_id_2              76 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             N 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             CYS 
_pdbx_validate_rmsd_angle.auth_seq_id_3              77 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                102.56 
_pdbx_validate_rmsd_angle.angle_target_value         122.70 
_pdbx_validate_rmsd_angle.angle_deviation            -20.14 
_pdbx_validate_rmsd_angle.angle_standard_deviation   1.60 
_pdbx_validate_rmsd_angle.linker_flag                Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 THR A 76  ? ? -116.86 52.32   
2 1 GLN A 107 ? ? 62.01   -121.00 
3 1 LYS A 108 ? ? -148.74 -8.96   
4 1 CYS A 237 ? ? -144.67 -2.17   
5 1 GLU A 299 ? ? -137.15 -146.80 
6 1 LEU A 467 ? ? 66.48   -5.56   
7 1 ASP A 478 ? ? 55.34   -109.70 
# 
_pdbx_validate_main_chain_plane.id                       1 
_pdbx_validate_main_chain_plane.PDB_model_num            1 
_pdbx_validate_main_chain_plane.auth_comp_id             THR 
_pdbx_validate_main_chain_plane.auth_asym_id             A 
_pdbx_validate_main_chain_plane.auth_seq_id              76 
_pdbx_validate_main_chain_plane.PDB_ins_code             ? 
_pdbx_validate_main_chain_plane.label_alt_id             ? 
_pdbx_validate_main_chain_plane.improper_torsion_angle   -27.61 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 62  ? A GLY 1   
2  1 Y 1 A PRO 63  ? A PRO 2   
3  1 Y 1 A SER 112 ? A SER 51  
4  1 Y 1 A HIS 113 ? A HIS 52  
5  1 Y 1 A ARG 151 ? A ARG 90  
6  1 Y 1 A TRP 152 ? A TRP 91  
7  1 Y 1 A GLN 153 ? A GLN 92  
8  1 Y 1 A ILE 154 ? A ILE 93  
9  1 Y 1 A SER 155 ? A SER 94  
10 1 Y 1 A SER 156 ? A SER 95  
11 1 Y 1 A PHE 157 ? A PHE 96  
12 1 Y 1 A GLU 158 ? A GLU 97  
13 1 Y 1 A GLU 159 ? A GLU 98  
14 1 Y 1 A GLN 160 ? A GLN 99  
15 1 Y 1 A GLY 213 ? A GLY 118 
16 1 Y 1 A SER 214 ? A SER 119 
17 1 Y 1 A GLY 215 ? A GLY 120 
18 1 Y 1 A SER 216 ? A SER 121 
19 1 Y 1 A HIS 217 ? A HIS 122 
20 1 Y 1 A TRP 218 ? A TRP 123 
21 1 Y 1 A GLY 294 ? A GLY 199 
22 1 Y 1 A THR 295 ? A THR 200 
23 1 Y 1 A LEU 296 ? A LEU 201 
24 1 Y 1 A ASN 297 ? A ASN 202 
25 1 Y 1 A TYR 427 ? A TYR 261 
26 1 Y 1 A HIS 428 ? A HIS 262 
27 1 Y 1 A SER 429 ? A SER 263 
28 1 Y 1 A ASN 430 ? A ASN 264 
29 1 Y 1 A ALA 431 ? A ALA 265 
30 1 Y 1 A SER 432 ? A SER 266 
31 1 Y 1 A THR 433 ? A THR 267 
32 1 Y 1 A TYR 434 ? A TYR 268 
33 1 Y 1 A ALA 463 ? A ALA 297 
34 1 Y 1 A ARG 464 ? A ARG 298 
35 1 Y 1 A ASN 465 ? A ASN 299 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1L7W C02  C  N N 1   
A1L7W C04  C  N N 2   
A1L7W C05  C  N S 3   
A1L7W C06  C  N N 4   
A1L7W C07  C  N N 5   
A1L7W C09  C  N N 6   
A1L7W C18  C  N N 7   
A1L7W C19  C  Y N 8   
A1L7W C22  C  Y N 9   
A1L7W C23  C  Y N 10  
A1L7W C24  C  Y N 11  
A1L7W C25  C  Y N 12  
A1L7W C26  C  N N 13  
A1L7W C28  C  Y N 14  
A1L7W C29  C  Y N 15  
A1L7W C30  C  Y N 16  
A1L7W N03  N  N N 17  
A1L7W N08  N  N N 18  
A1L7W N17  N  N N 19  
A1L7W N20  N  Y N 20  
A1L7W N21  N  Y N 21  
A1L7W N27  N  N N 22  
A1L7W O01  O  N N 23  
A1L7W O31  O  Y N 24  
A1L7W H1   H  N N 25  
A1L7W H2   H  N N 26  
A1L7W H3   H  N N 27  
A1L7W H4   H  N N 28  
A1L7W H5   H  N N 29  
A1L7W H6   H  N N 30  
A1L7W H7   H  N N 31  
A1L7W H8   H  N N 32  
A1L7W H9   H  N N 33  
A1L7W H10  H  N N 34  
A1L7W H11  H  N N 35  
A1L7W H12  H  N N 36  
A1L7W H13  H  N N 37  
A1L7W H14  H  N N 38  
A1L7W H15  H  N N 39  
A1L7W H16  H  N N 40  
ALA   N    N  N N 41  
ALA   CA   C  N S 42  
ALA   C    C  N N 43  
ALA   O    O  N N 44  
ALA   CB   C  N N 45  
ALA   OXT  O  N N 46  
ALA   H    H  N N 47  
ALA   H2   H  N N 48  
ALA   HA   H  N N 49  
ALA   HB1  H  N N 50  
ALA   HB2  H  N N 51  
ALA   HB3  H  N N 52  
ALA   HXT  H  N N 53  
ARG   N    N  N N 54  
ARG   CA   C  N S 55  
ARG   C    C  N N 56  
ARG   O    O  N N 57  
ARG   CB   C  N N 58  
ARG   CG   C  N N 59  
ARG   CD   C  N N 60  
ARG   NE   N  N N 61  
ARG   CZ   C  N N 62  
ARG   NH1  N  N N 63  
ARG   NH2  N  N N 64  
ARG   OXT  O  N N 65  
ARG   H    H  N N 66  
ARG   H2   H  N N 67  
ARG   HA   H  N N 68  
ARG   HB2  H  N N 69  
ARG   HB3  H  N N 70  
ARG   HG2  H  N N 71  
ARG   HG3  H  N N 72  
ARG   HD2  H  N N 73  
ARG   HD3  H  N N 74  
ARG   HE   H  N N 75  
ARG   HH11 H  N N 76  
ARG   HH12 H  N N 77  
ARG   HH21 H  N N 78  
ARG   HH22 H  N N 79  
ARG   HXT  H  N N 80  
ASN   N    N  N N 81  
ASN   CA   C  N S 82  
ASN   C    C  N N 83  
ASN   O    O  N N 84  
ASN   CB   C  N N 85  
ASN   CG   C  N N 86  
ASN   OD1  O  N N 87  
ASN   ND2  N  N N 88  
ASN   OXT  O  N N 89  
ASN   H    H  N N 90  
ASN   H2   H  N N 91  
ASN   HA   H  N N 92  
ASN   HB2  H  N N 93  
ASN   HB3  H  N N 94  
ASN   HD21 H  N N 95  
ASN   HD22 H  N N 96  
ASN   HXT  H  N N 97  
ASP   N    N  N N 98  
ASP   CA   C  N S 99  
ASP   C    C  N N 100 
ASP   O    O  N N 101 
ASP   CB   C  N N 102 
ASP   CG   C  N N 103 
ASP   OD1  O  N N 104 
ASP   OD2  O  N N 105 
ASP   OXT  O  N N 106 
ASP   H    H  N N 107 
ASP   H2   H  N N 108 
ASP   HA   H  N N 109 
ASP   HB2  H  N N 110 
ASP   HB3  H  N N 111 
ASP   HD2  H  N N 112 
ASP   HXT  H  N N 113 
CYS   N    N  N N 114 
CYS   CA   C  N R 115 
CYS   C    C  N N 116 
CYS   O    O  N N 117 
CYS   CB   C  N N 118 
CYS   SG   S  N N 119 
CYS   OXT  O  N N 120 
CYS   H    H  N N 121 
CYS   H2   H  N N 122 
CYS   HA   H  N N 123 
CYS   HB2  H  N N 124 
CYS   HB3  H  N N 125 
CYS   HG   H  N N 126 
CYS   HXT  H  N N 127 
GLN   N    N  N N 128 
GLN   CA   C  N S 129 
GLN   C    C  N N 130 
GLN   O    O  N N 131 
GLN   CB   C  N N 132 
GLN   CG   C  N N 133 
GLN   CD   C  N N 134 
GLN   OE1  O  N N 135 
GLN   NE2  N  N N 136 
GLN   OXT  O  N N 137 
GLN   H    H  N N 138 
GLN   H2   H  N N 139 
GLN   HA   H  N N 140 
GLN   HB2  H  N N 141 
GLN   HB3  H  N N 142 
GLN   HG2  H  N N 143 
GLN   HG3  H  N N 144 
GLN   HE21 H  N N 145 
GLN   HE22 H  N N 146 
GLN   HXT  H  N N 147 
GLU   N    N  N N 148 
GLU   CA   C  N S 149 
GLU   C    C  N N 150 
GLU   O    O  N N 151 
GLU   CB   C  N N 152 
GLU   CG   C  N N 153 
GLU   CD   C  N N 154 
GLU   OE1  O  N N 155 
GLU   OE2  O  N N 156 
GLU   OXT  O  N N 157 
GLU   H    H  N N 158 
GLU   H2   H  N N 159 
GLU   HA   H  N N 160 
GLU   HB2  H  N N 161 
GLU   HB3  H  N N 162 
GLU   HG2  H  N N 163 
GLU   HG3  H  N N 164 
GLU   HE2  H  N N 165 
GLU   HXT  H  N N 166 
GLY   N    N  N N 167 
GLY   CA   C  N N 168 
GLY   C    C  N N 169 
GLY   O    O  N N 170 
GLY   OXT  O  N N 171 
GLY   H    H  N N 172 
GLY   H2   H  N N 173 
GLY   HA2  H  N N 174 
GLY   HA3  H  N N 175 
GLY   HXT  H  N N 176 
HIS   N    N  N N 177 
HIS   CA   C  N S 178 
HIS   C    C  N N 179 
HIS   O    O  N N 180 
HIS   CB   C  N N 181 
HIS   CG   C  Y N 182 
HIS   ND1  N  Y N 183 
HIS   CD2  C  Y N 184 
HIS   CE1  C  Y N 185 
HIS   NE2  N  Y N 186 
HIS   OXT  O  N N 187 
HIS   H    H  N N 188 
HIS   H2   H  N N 189 
HIS   HA   H  N N 190 
HIS   HB2  H  N N 191 
HIS   HB3  H  N N 192 
HIS   HD1  H  N N 193 
HIS   HD2  H  N N 194 
HIS   HE1  H  N N 195 
HIS   HE2  H  N N 196 
HIS   HXT  H  N N 197 
HOH   O    O  N N 198 
HOH   H1   H  N N 199 
HOH   H2   H  N N 200 
ILE   N    N  N N 201 
ILE   CA   C  N S 202 
ILE   C    C  N N 203 
ILE   O    O  N N 204 
ILE   CB   C  N S 205 
ILE   CG1  C  N N 206 
ILE   CG2  C  N N 207 
ILE   CD1  C  N N 208 
ILE   OXT  O  N N 209 
ILE   H    H  N N 210 
ILE   H2   H  N N 211 
ILE   HA   H  N N 212 
ILE   HB   H  N N 213 
ILE   HG12 H  N N 214 
ILE   HG13 H  N N 215 
ILE   HG21 H  N N 216 
ILE   HG22 H  N N 217 
ILE   HG23 H  N N 218 
ILE   HD11 H  N N 219 
ILE   HD12 H  N N 220 
ILE   HD13 H  N N 221 
ILE   HXT  H  N N 222 
LEU   N    N  N N 223 
LEU   CA   C  N S 224 
LEU   C    C  N N 225 
LEU   O    O  N N 226 
LEU   CB   C  N N 227 
LEU   CG   C  N N 228 
LEU   CD1  C  N N 229 
LEU   CD2  C  N N 230 
LEU   OXT  O  N N 231 
LEU   H    H  N N 232 
LEU   H2   H  N N 233 
LEU   HA   H  N N 234 
LEU   HB2  H  N N 235 
LEU   HB3  H  N N 236 
LEU   HG   H  N N 237 
LEU   HD11 H  N N 238 
LEU   HD12 H  N N 239 
LEU   HD13 H  N N 240 
LEU   HD21 H  N N 241 
LEU   HD22 H  N N 242 
LEU   HD23 H  N N 243 
LEU   HXT  H  N N 244 
LYS   N    N  N N 245 
LYS   CA   C  N S 246 
LYS   C    C  N N 247 
LYS   O    O  N N 248 
LYS   CB   C  N N 249 
LYS   CG   C  N N 250 
LYS   CD   C  N N 251 
LYS   CE   C  N N 252 
LYS   NZ   N  N N 253 
LYS   OXT  O  N N 254 
LYS   H    H  N N 255 
LYS   H2   H  N N 256 
LYS   HA   H  N N 257 
LYS   HB2  H  N N 258 
LYS   HB3  H  N N 259 
LYS   HG2  H  N N 260 
LYS   HG3  H  N N 261 
LYS   HD2  H  N N 262 
LYS   HD3  H  N N 263 
LYS   HE2  H  N N 264 
LYS   HE3  H  N N 265 
LYS   HZ1  H  N N 266 
LYS   HZ2  H  N N 267 
LYS   HZ3  H  N N 268 
LYS   HXT  H  N N 269 
MET   N    N  N N 270 
MET   CA   C  N S 271 
MET   C    C  N N 272 
MET   O    O  N N 273 
MET   CB   C  N N 274 
MET   CG   C  N N 275 
MET   SD   S  N N 276 
MET   CE   C  N N 277 
MET   OXT  O  N N 278 
MET   H    H  N N 279 
MET   H2   H  N N 280 
MET   HA   H  N N 281 
MET   HB2  H  N N 282 
MET   HB3  H  N N 283 
MET   HG2  H  N N 284 
MET   HG3  H  N N 285 
MET   HE1  H  N N 286 
MET   HE2  H  N N 287 
MET   HE3  H  N N 288 
MET   HXT  H  N N 289 
PHE   N    N  N N 290 
PHE   CA   C  N S 291 
PHE   C    C  N N 292 
PHE   O    O  N N 293 
PHE   CB   C  N N 294 
PHE   CG   C  Y N 295 
PHE   CD1  C  Y N 296 
PHE   CD2  C  Y N 297 
PHE   CE1  C  Y N 298 
PHE   CE2  C  Y N 299 
PHE   CZ   C  Y N 300 
PHE   OXT  O  N N 301 
PHE   H    H  N N 302 
PHE   H2   H  N N 303 
PHE   HA   H  N N 304 
PHE   HB2  H  N N 305 
PHE   HB3  H  N N 306 
PHE   HD1  H  N N 307 
PHE   HD2  H  N N 308 
PHE   HE1  H  N N 309 
PHE   HE2  H  N N 310 
PHE   HZ   H  N N 311 
PHE   HXT  H  N N 312 
PRO   N    N  N N 313 
PRO   CA   C  N S 314 
PRO   C    C  N N 315 
PRO   O    O  N N 316 
PRO   CB   C  N N 317 
PRO   CG   C  N N 318 
PRO   CD   C  N N 319 
PRO   OXT  O  N N 320 
PRO   H    H  N N 321 
PRO   HA   H  N N 322 
PRO   HB2  H  N N 323 
PRO   HB3  H  N N 324 
PRO   HG2  H  N N 325 
PRO   HG3  H  N N 326 
PRO   HD2  H  N N 327 
PRO   HD3  H  N N 328 
PRO   HXT  H  N N 329 
SER   N    N  N N 330 
SER   CA   C  N S 331 
SER   C    C  N N 332 
SER   O    O  N N 333 
SER   CB   C  N N 334 
SER   OG   O  N N 335 
SER   OXT  O  N N 336 
SER   H    H  N N 337 
SER   H2   H  N N 338 
SER   HA   H  N N 339 
SER   HB2  H  N N 340 
SER   HB3  H  N N 341 
SER   HG   H  N N 342 
SER   HXT  H  N N 343 
THR   N    N  N N 344 
THR   CA   C  N S 345 
THR   C    C  N N 346 
THR   O    O  N N 347 
THR   CB   C  N R 348 
THR   OG1  O  N N 349 
THR   CG2  C  N N 350 
THR   OXT  O  N N 351 
THR   H    H  N N 352 
THR   H2   H  N N 353 
THR   HA   H  N N 354 
THR   HB   H  N N 355 
THR   HG1  H  N N 356 
THR   HG21 H  N N 357 
THR   HG22 H  N N 358 
THR   HG23 H  N N 359 
THR   HXT  H  N N 360 
TRP   N    N  N N 361 
TRP   CA   C  N S 362 
TRP   C    C  N N 363 
TRP   O    O  N N 364 
TRP   CB   C  N N 365 
TRP   CG   C  Y N 366 
TRP   CD1  C  Y N 367 
TRP   CD2  C  Y N 368 
TRP   NE1  N  Y N 369 
TRP   CE2  C  Y N 370 
TRP   CE3  C  Y N 371 
TRP   CZ2  C  Y N 372 
TRP   CZ3  C  Y N 373 
TRP   CH2  C  Y N 374 
TRP   OXT  O  N N 375 
TRP   H    H  N N 376 
TRP   H2   H  N N 377 
TRP   HA   H  N N 378 
TRP   HB2  H  N N 379 
TRP   HB3  H  N N 380 
TRP   HD1  H  N N 381 
TRP   HE1  H  N N 382 
TRP   HE3  H  N N 383 
TRP   HZ2  H  N N 384 
TRP   HZ3  H  N N 385 
TRP   HH2  H  N N 386 
TRP   HXT  H  N N 387 
TYR   N    N  N N 388 
TYR   CA   C  N S 389 
TYR   C    C  N N 390 
TYR   O    O  N N 391 
TYR   CB   C  N N 392 
TYR   CG   C  Y N 393 
TYR   CD1  C  Y N 394 
TYR   CD2  C  Y N 395 
TYR   CE1  C  Y N 396 
TYR   CE2  C  Y N 397 
TYR   CZ   C  Y N 398 
TYR   OH   O  N N 399 
TYR   OXT  O  N N 400 
TYR   H    H  N N 401 
TYR   H2   H  N N 402 
TYR   HA   H  N N 403 
TYR   HB2  H  N N 404 
TYR   HB3  H  N N 405 
TYR   HD1  H  N N 406 
TYR   HD2  H  N N 407 
TYR   HE1  H  N N 408 
TYR   HE2  H  N N 409 
TYR   HH   H  N N 410 
TYR   HXT  H  N N 411 
VAL   N    N  N N 412 
VAL   CA   C  N S 413 
VAL   C    C  N N 414 
VAL   O    O  N N 415 
VAL   CB   C  N N 416 
VAL   CG1  C  N N 417 
VAL   CG2  C  N N 418 
VAL   OXT  O  N N 419 
VAL   H    H  N N 420 
VAL   H2   H  N N 421 
VAL   HA   H  N N 422 
VAL   HB   H  N N 423 
VAL   HG11 H  N N 424 
VAL   HG12 H  N N 425 
VAL   HG13 H  N N 426 
VAL   HG21 H  N N 427 
VAL   HG22 H  N N 428 
VAL   HG23 H  N N 429 
VAL   HXT  H  N N 430 
ZN    ZN   ZN N N 431 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1L7W N17 C09  doub N N 1   
A1L7W C09 N08  sing N N 2   
A1L7W C07 N08  sing N N 3   
A1L7W C07 C06  sing N N 4   
A1L7W N08 C18  sing N N 5   
A1L7W C06 C05  sing N N 6   
A1L7W C05 C18  sing N N 7   
A1L7W C05 C04  sing N N 8   
A1L7W C04 N03  sing N N 9   
A1L7W N03 C02  sing N N 10  
A1L7W O01 C02  doub N N 11  
A1L7W C02 C19  sing N N 12  
A1L7W C19 O31  sing Y N 13  
A1L7W C19 N20  doub Y N 14  
A1L7W O31 C22  sing Y N 15  
A1L7W N20 N21  sing Y N 16  
A1L7W C22 N21  doub Y N 17  
A1L7W C22 C23  sing N N 18  
A1L7W C24 C23  doub Y N 19  
A1L7W C24 C25  sing Y N 20  
A1L7W N27 C26  trip N N 21  
A1L7W C23 C30  sing Y N 22  
A1L7W C26 C25  sing N N 23  
A1L7W C25 C28  doub Y N 24  
A1L7W C30 C29  doub Y N 25  
A1L7W C28 C29  sing Y N 26  
A1L7W C04 H1   sing N N 27  
A1L7W C04 H2   sing N N 28  
A1L7W C05 H3   sing N N 29  
A1L7W C06 H4   sing N N 30  
A1L7W C06 H5   sing N N 31  
A1L7W C07 H6   sing N N 32  
A1L7W C07 H7   sing N N 33  
A1L7W C09 H8   sing N N 34  
A1L7W C18 H9   sing N N 35  
A1L7W C18 H10  sing N N 36  
A1L7W C24 H11  sing N N 37  
A1L7W C28 H12  sing N N 38  
A1L7W C29 H13  sing N N 39  
A1L7W C30 H14  sing N N 40  
A1L7W N03 H15  sing N N 41  
A1L7W N17 H16  sing N N 42  
ALA   N   CA   sing N N 43  
ALA   N   H    sing N N 44  
ALA   N   H2   sing N N 45  
ALA   CA  C    sing N N 46  
ALA   CA  CB   sing N N 47  
ALA   CA  HA   sing N N 48  
ALA   C   O    doub N N 49  
ALA   C   OXT  sing N N 50  
ALA   CB  HB1  sing N N 51  
ALA   CB  HB2  sing N N 52  
ALA   CB  HB3  sing N N 53  
ALA   OXT HXT  sing N N 54  
ARG   N   CA   sing N N 55  
ARG   N   H    sing N N 56  
ARG   N   H2   sing N N 57  
ARG   CA  C    sing N N 58  
ARG   CA  CB   sing N N 59  
ARG   CA  HA   sing N N 60  
ARG   C   O    doub N N 61  
ARG   C   OXT  sing N N 62  
ARG   CB  CG   sing N N 63  
ARG   CB  HB2  sing N N 64  
ARG   CB  HB3  sing N N 65  
ARG   CG  CD   sing N N 66  
ARG   CG  HG2  sing N N 67  
ARG   CG  HG3  sing N N 68  
ARG   CD  NE   sing N N 69  
ARG   CD  HD2  sing N N 70  
ARG   CD  HD3  sing N N 71  
ARG   NE  CZ   sing N N 72  
ARG   NE  HE   sing N N 73  
ARG   CZ  NH1  sing N N 74  
ARG   CZ  NH2  doub N N 75  
ARG   NH1 HH11 sing N N 76  
ARG   NH1 HH12 sing N N 77  
ARG   NH2 HH21 sing N N 78  
ARG   NH2 HH22 sing N N 79  
ARG   OXT HXT  sing N N 80  
ASN   N   CA   sing N N 81  
ASN   N   H    sing N N 82  
ASN   N   H2   sing N N 83  
ASN   CA  C    sing N N 84  
ASN   CA  CB   sing N N 85  
ASN   CA  HA   sing N N 86  
ASN   C   O    doub N N 87  
ASN   C   OXT  sing N N 88  
ASN   CB  CG   sing N N 89  
ASN   CB  HB2  sing N N 90  
ASN   CB  HB3  sing N N 91  
ASN   CG  OD1  doub N N 92  
ASN   CG  ND2  sing N N 93  
ASN   ND2 HD21 sing N N 94  
ASN   ND2 HD22 sing N N 95  
ASN   OXT HXT  sing N N 96  
ASP   N   CA   sing N N 97  
ASP   N   H    sing N N 98  
ASP   N   H2   sing N N 99  
ASP   CA  C    sing N N 100 
ASP   CA  CB   sing N N 101 
ASP   CA  HA   sing N N 102 
ASP   C   O    doub N N 103 
ASP   C   OXT  sing N N 104 
ASP   CB  CG   sing N N 105 
ASP   CB  HB2  sing N N 106 
ASP   CB  HB3  sing N N 107 
ASP   CG  OD1  doub N N 108 
ASP   CG  OD2  sing N N 109 
ASP   OD2 HD2  sing N N 110 
ASP   OXT HXT  sing N N 111 
CYS   N   CA   sing N N 112 
CYS   N   H    sing N N 113 
CYS   N   H2   sing N N 114 
CYS   CA  C    sing N N 115 
CYS   CA  CB   sing N N 116 
CYS   CA  HA   sing N N 117 
CYS   C   O    doub N N 118 
CYS   C   OXT  sing N N 119 
CYS   CB  SG   sing N N 120 
CYS   CB  HB2  sing N N 121 
CYS   CB  HB3  sing N N 122 
CYS   SG  HG   sing N N 123 
CYS   OXT HXT  sing N N 124 
GLN   N   CA   sing N N 125 
GLN   N   H    sing N N 126 
GLN   N   H2   sing N N 127 
GLN   CA  C    sing N N 128 
GLN   CA  CB   sing N N 129 
GLN   CA  HA   sing N N 130 
GLN   C   O    doub N N 131 
GLN   C   OXT  sing N N 132 
GLN   CB  CG   sing N N 133 
GLN   CB  HB2  sing N N 134 
GLN   CB  HB3  sing N N 135 
GLN   CG  CD   sing N N 136 
GLN   CG  HG2  sing N N 137 
GLN   CG  HG3  sing N N 138 
GLN   CD  OE1  doub N N 139 
GLN   CD  NE2  sing N N 140 
GLN   NE2 HE21 sing N N 141 
GLN   NE2 HE22 sing N N 142 
GLN   OXT HXT  sing N N 143 
GLU   N   CA   sing N N 144 
GLU   N   H    sing N N 145 
GLU   N   H2   sing N N 146 
GLU   CA  C    sing N N 147 
GLU   CA  CB   sing N N 148 
GLU   CA  HA   sing N N 149 
GLU   C   O    doub N N 150 
GLU   C   OXT  sing N N 151 
GLU   CB  CG   sing N N 152 
GLU   CB  HB2  sing N N 153 
GLU   CB  HB3  sing N N 154 
GLU   CG  CD   sing N N 155 
GLU   CG  HG2  sing N N 156 
GLU   CG  HG3  sing N N 157 
GLU   CD  OE1  doub N N 158 
GLU   CD  OE2  sing N N 159 
GLU   OE2 HE2  sing N N 160 
GLU   OXT HXT  sing N N 161 
GLY   N   CA   sing N N 162 
GLY   N   H    sing N N 163 
GLY   N   H2   sing N N 164 
GLY   CA  C    sing N N 165 
GLY   CA  HA2  sing N N 166 
GLY   CA  HA3  sing N N 167 
GLY   C   O    doub N N 168 
GLY   C   OXT  sing N N 169 
GLY   OXT HXT  sing N N 170 
HIS   N   CA   sing N N 171 
HIS   N   H    sing N N 172 
HIS   N   H2   sing N N 173 
HIS   CA  C    sing N N 174 
HIS   CA  CB   sing N N 175 
HIS   CA  HA   sing N N 176 
HIS   C   O    doub N N 177 
HIS   C   OXT  sing N N 178 
HIS   CB  CG   sing N N 179 
HIS   CB  HB2  sing N N 180 
HIS   CB  HB3  sing N N 181 
HIS   CG  ND1  sing Y N 182 
HIS   CG  CD2  doub Y N 183 
HIS   ND1 CE1  doub Y N 184 
HIS   ND1 HD1  sing N N 185 
HIS   CD2 NE2  sing Y N 186 
HIS   CD2 HD2  sing N N 187 
HIS   CE1 NE2  sing Y N 188 
HIS   CE1 HE1  sing N N 189 
HIS   NE2 HE2  sing N N 190 
HIS   OXT HXT  sing N N 191 
HOH   O   H1   sing N N 192 
HOH   O   H2   sing N N 193 
ILE   N   CA   sing N N 194 
ILE   N   H    sing N N 195 
ILE   N   H2   sing N N 196 
ILE   CA  C    sing N N 197 
ILE   CA  CB   sing N N 198 
ILE   CA  HA   sing N N 199 
ILE   C   O    doub N N 200 
ILE   C   OXT  sing N N 201 
ILE   CB  CG1  sing N N 202 
ILE   CB  CG2  sing N N 203 
ILE   CB  HB   sing N N 204 
ILE   CG1 CD1  sing N N 205 
ILE   CG1 HG12 sing N N 206 
ILE   CG1 HG13 sing N N 207 
ILE   CG2 HG21 sing N N 208 
ILE   CG2 HG22 sing N N 209 
ILE   CG2 HG23 sing N N 210 
ILE   CD1 HD11 sing N N 211 
ILE   CD1 HD12 sing N N 212 
ILE   CD1 HD13 sing N N 213 
ILE   OXT HXT  sing N N 214 
LEU   N   CA   sing N N 215 
LEU   N   H    sing N N 216 
LEU   N   H2   sing N N 217 
LEU   CA  C    sing N N 218 
LEU   CA  CB   sing N N 219 
LEU   CA  HA   sing N N 220 
LEU   C   O    doub N N 221 
LEU   C   OXT  sing N N 222 
LEU   CB  CG   sing N N 223 
LEU   CB  HB2  sing N N 224 
LEU   CB  HB3  sing N N 225 
LEU   CG  CD1  sing N N 226 
LEU   CG  CD2  sing N N 227 
LEU   CG  HG   sing N N 228 
LEU   CD1 HD11 sing N N 229 
LEU   CD1 HD12 sing N N 230 
LEU   CD1 HD13 sing N N 231 
LEU   CD2 HD21 sing N N 232 
LEU   CD2 HD22 sing N N 233 
LEU   CD2 HD23 sing N N 234 
LEU   OXT HXT  sing N N 235 
LYS   N   CA   sing N N 236 
LYS   N   H    sing N N 237 
LYS   N   H2   sing N N 238 
LYS   CA  C    sing N N 239 
LYS   CA  CB   sing N N 240 
LYS   CA  HA   sing N N 241 
LYS   C   O    doub N N 242 
LYS   C   OXT  sing N N 243 
LYS   CB  CG   sing N N 244 
LYS   CB  HB2  sing N N 245 
LYS   CB  HB3  sing N N 246 
LYS   CG  CD   sing N N 247 
LYS   CG  HG2  sing N N 248 
LYS   CG  HG3  sing N N 249 
LYS   CD  CE   sing N N 250 
LYS   CD  HD2  sing N N 251 
LYS   CD  HD3  sing N N 252 
LYS   CE  NZ   sing N N 253 
LYS   CE  HE2  sing N N 254 
LYS   CE  HE3  sing N N 255 
LYS   NZ  HZ1  sing N N 256 
LYS   NZ  HZ2  sing N N 257 
LYS   NZ  HZ3  sing N N 258 
LYS   OXT HXT  sing N N 259 
MET   N   CA   sing N N 260 
MET   N   H    sing N N 261 
MET   N   H2   sing N N 262 
MET   CA  C    sing N N 263 
MET   CA  CB   sing N N 264 
MET   CA  HA   sing N N 265 
MET   C   O    doub N N 266 
MET   C   OXT  sing N N 267 
MET   CB  CG   sing N N 268 
MET   CB  HB2  sing N N 269 
MET   CB  HB3  sing N N 270 
MET   CG  SD   sing N N 271 
MET   CG  HG2  sing N N 272 
MET   CG  HG3  sing N N 273 
MET   SD  CE   sing N N 274 
MET   CE  HE1  sing N N 275 
MET   CE  HE2  sing N N 276 
MET   CE  HE3  sing N N 277 
MET   OXT HXT  sing N N 278 
PHE   N   CA   sing N N 279 
PHE   N   H    sing N N 280 
PHE   N   H2   sing N N 281 
PHE   CA  C    sing N N 282 
PHE   CA  CB   sing N N 283 
PHE   CA  HA   sing N N 284 
PHE   C   O    doub N N 285 
PHE   C   OXT  sing N N 286 
PHE   CB  CG   sing N N 287 
PHE   CB  HB2  sing N N 288 
PHE   CB  HB3  sing N N 289 
PHE   CG  CD1  doub Y N 290 
PHE   CG  CD2  sing Y N 291 
PHE   CD1 CE1  sing Y N 292 
PHE   CD1 HD1  sing N N 293 
PHE   CD2 CE2  doub Y N 294 
PHE   CD2 HD2  sing N N 295 
PHE   CE1 CZ   doub Y N 296 
PHE   CE1 HE1  sing N N 297 
PHE   CE2 CZ   sing Y N 298 
PHE   CE2 HE2  sing N N 299 
PHE   CZ  HZ   sing N N 300 
PHE   OXT HXT  sing N N 301 
PRO   N   CA   sing N N 302 
PRO   N   CD   sing N N 303 
PRO   N   H    sing N N 304 
PRO   CA  C    sing N N 305 
PRO   CA  CB   sing N N 306 
PRO   CA  HA   sing N N 307 
PRO   C   O    doub N N 308 
PRO   C   OXT  sing N N 309 
PRO   CB  CG   sing N N 310 
PRO   CB  HB2  sing N N 311 
PRO   CB  HB3  sing N N 312 
PRO   CG  CD   sing N N 313 
PRO   CG  HG2  sing N N 314 
PRO   CG  HG3  sing N N 315 
PRO   CD  HD2  sing N N 316 
PRO   CD  HD3  sing N N 317 
PRO   OXT HXT  sing N N 318 
SER   N   CA   sing N N 319 
SER   N   H    sing N N 320 
SER   N   H2   sing N N 321 
SER   CA  C    sing N N 322 
SER   CA  CB   sing N N 323 
SER   CA  HA   sing N N 324 
SER   C   O    doub N N 325 
SER   C   OXT  sing N N 326 
SER   CB  OG   sing N N 327 
SER   CB  HB2  sing N N 328 
SER   CB  HB3  sing N N 329 
SER   OG  HG   sing N N 330 
SER   OXT HXT  sing N N 331 
THR   N   CA   sing N N 332 
THR   N   H    sing N N 333 
THR   N   H2   sing N N 334 
THR   CA  C    sing N N 335 
THR   CA  CB   sing N N 336 
THR   CA  HA   sing N N 337 
THR   C   O    doub N N 338 
THR   C   OXT  sing N N 339 
THR   CB  OG1  sing N N 340 
THR   CB  CG2  sing N N 341 
THR   CB  HB   sing N N 342 
THR   OG1 HG1  sing N N 343 
THR   CG2 HG21 sing N N 344 
THR   CG2 HG22 sing N N 345 
THR   CG2 HG23 sing N N 346 
THR   OXT HXT  sing N N 347 
TRP   N   CA   sing N N 348 
TRP   N   H    sing N N 349 
TRP   N   H2   sing N N 350 
TRP   CA  C    sing N N 351 
TRP   CA  CB   sing N N 352 
TRP   CA  HA   sing N N 353 
TRP   C   O    doub N N 354 
TRP   C   OXT  sing N N 355 
TRP   CB  CG   sing N N 356 
TRP   CB  HB2  sing N N 357 
TRP   CB  HB3  sing N N 358 
TRP   CG  CD1  doub Y N 359 
TRP   CG  CD2  sing Y N 360 
TRP   CD1 NE1  sing Y N 361 
TRP   CD1 HD1  sing N N 362 
TRP   CD2 CE2  doub Y N 363 
TRP   CD2 CE3  sing Y N 364 
TRP   NE1 CE2  sing Y N 365 
TRP   NE1 HE1  sing N N 366 
TRP   CE2 CZ2  sing Y N 367 
TRP   CE3 CZ3  doub Y N 368 
TRP   CE3 HE3  sing N N 369 
TRP   CZ2 CH2  doub Y N 370 
TRP   CZ2 HZ2  sing N N 371 
TRP   CZ3 CH2  sing Y N 372 
TRP   CZ3 HZ3  sing N N 373 
TRP   CH2 HH2  sing N N 374 
TRP   OXT HXT  sing N N 375 
TYR   N   CA   sing N N 376 
TYR   N   H    sing N N 377 
TYR   N   H2   sing N N 378 
TYR   CA  C    sing N N 379 
TYR   CA  CB   sing N N 380 
TYR   CA  HA   sing N N 381 
TYR   C   O    doub N N 382 
TYR   C   OXT  sing N N 383 
TYR   CB  CG   sing N N 384 
TYR   CB  HB2  sing N N 385 
TYR   CB  HB3  sing N N 386 
TYR   CG  CD1  doub Y N 387 
TYR   CG  CD2  sing Y N 388 
TYR   CD1 CE1  sing Y N 389 
TYR   CD1 HD1  sing N N 390 
TYR   CD2 CE2  doub Y N 391 
TYR   CD2 HD2  sing N N 392 
TYR   CE1 CZ   doub Y N 393 
TYR   CE1 HE1  sing N N 394 
TYR   CE2 CZ   sing Y N 395 
TYR   CE2 HE2  sing N N 396 
TYR   CZ  OH   sing N N 397 
TYR   OH  HH   sing N N 398 
TYR   OXT HXT  sing N N 399 
VAL   N   CA   sing N N 400 
VAL   N   H    sing N N 401 
VAL   N   H2   sing N N 402 
VAL   CA  C    sing N N 403 
VAL   CA  CB   sing N N 404 
VAL   CA  HA   sing N N 405 
VAL   C   O    doub N N 406 
VAL   C   OXT  sing N N 407 
VAL   CB  CG1  sing N N 408 
VAL   CB  CG2  sing N N 409 
VAL   CB  HB   sing N N 410 
VAL   CG1 HG11 sing N N 411 
VAL   CG1 HG12 sing N N 412 
VAL   CG1 HG13 sing N N 413 
VAL   CG2 HG21 sing N N 414 
VAL   CG2 HG22 sing N N 415 
VAL   CG2 HG23 sing N N 416 
VAL   OXT HXT  sing N N 417 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5OHP 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9LYF 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.018865 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.016425 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009755 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
N  
O  
S  
ZN 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . LYS   A 1 3   ? -0.492  3.873   -14.763 1.00 97.49  ? 64  LYS   A N   1 
ATOM   2    C  CA  . LYS   A 1 3   ? -0.567  2.633   -13.996 1.00 96.67  ? 64  LYS   A CA  1 
ATOM   3    C  C   . LYS   A 1 3   ? 0.047   2.803   -12.602 1.00 94.67  ? 64  LYS   A C   1 
ATOM   4    O  O   . LYS   A 1 3   ? 1.152   2.327   -12.339 1.00 87.49  ? 64  LYS   A O   1 
ATOM   5    C  CB  . LYS   A 1 3   ? 0.134   1.497   -14.751 1.00 88.60  ? 64  LYS   A CB  1 
ATOM   6    C  CG  . LYS   A 1 3   ? -0.477  1.175   -16.111 1.00 78.63  ? 64  LYS   A CG  1 
ATOM   7    N  N   . GLY   A 1 4   ? -0.672  3.484   -11.711 1.00 94.33  ? 65  GLY   A N   1 
ATOM   8    C  CA  . GLY   A 1 4   ? -0.176  3.711   -10.367 1.00 82.61  ? 65  GLY   A CA  1 
ATOM   9    C  C   . GLY   A 1 4   ? -0.369  2.519   -9.452  1.00 78.91  ? 65  GLY   A C   1 
ATOM   10   O  O   . GLY   A 1 4   ? -1.300  2.497   -8.638  1.00 68.62  ? 65  GLY   A O   1 
ATOM   11   N  N   . LEU   A 1 5   ? 0.514   1.528   -9.578  1.00 76.37  ? 66  LEU   A N   1 
ATOM   12   C  CA  . LEU   A 1 5   ? 0.468   0.289   -8.814  1.00 60.04  ? 66  LEU   A CA  1 
ATOM   13   C  C   . LEU   A 1 5   ? 1.765   0.097   -8.039  1.00 56.41  ? 66  LEU   A C   1 
ATOM   14   O  O   . LEU   A 1 5   ? 2.782   0.738   -8.312  1.00 62.63  ? 66  LEU   A O   1 
ATOM   15   C  CB  . LEU   A 1 5   ? 0.224   -0.917  -9.731  1.00 52.49  ? 66  LEU   A CB  1 
ATOM   16   C  CG  . LEU   A 1 5   ? -0.787  -0.742  -10.866 1.00 65.13  ? 66  LEU   A CG  1 
ATOM   17   C  CD1 . LEU   A 1 5   ? -0.826  -1.984  -11.753 1.00 74.59  ? 66  LEU   A CD1 1 
ATOM   18   C  CD2 . LEU   A 1 5   ? -2.173  -0.403  -10.331 1.00 58.08  ? 66  LEU   A CD2 1 
ATOM   19   N  N   . VAL   A 1 6   ? 1.720   -0.805  -7.065  1.00 59.43  ? 67  VAL   A N   1 
ATOM   20   C  CA  . VAL   A 1 6   ? 2.902   -1.155  -6.280  1.00 47.64  ? 67  VAL   A CA  1 
ATOM   21   C  C   . VAL   A 1 6   ? 3.494   -2.443  -6.837  1.00 43.38  ? 67  VAL   A C   1 
ATOM   22   O  O   . VAL   A 1 6   ? 2.789   -3.210  -7.510  1.00 39.65  ? 67  VAL   A O   1 
ATOM   23   C  CB  . VAL   A 1 6   ? 2.570   -1.311  -4.785  1.00 47.30  ? 67  VAL   A CB  1 
ATOM   24   C  CG1 . VAL   A 1 6   ? 2.398   0.048   -4.122  1.00 48.54  ? 67  VAL   A CG1 1 
ATOM   25   C  CG2 . VAL   A 1 6   ? 1.332   -2.177  -4.599  1.00 48.09  ? 67  VAL   A CG2 1 
ATOM   26   N  N   . PRO   A 1 7   ? 4.776   -2.712  -6.595  1.00 42.34  ? 68  PRO   A N   1 
ATOM   27   C  CA  . PRO   A 1 7   ? 5.347   -4.006  -6.980  1.00 38.28  ? 68  PRO   A CA  1 
ATOM   28   C  C   . PRO   A 1 7   ? 4.706   -5.155  -6.219  1.00 32.08  ? 68  PRO   A C   1 
ATOM   29   O  O   . PRO   A 1 7   ? 4.235   -5.003  -5.090  1.00 25.44  ? 68  PRO   A O   1 
ATOM   30   C  CB  . PRO   A 1 7   ? 6.828   -3.866  -6.609  1.00 39.69  ? 68  PRO   A CB  1 
ATOM   31   C  CG  . PRO   A 1 7   ? 7.071   -2.390  -6.532  1.00 40.09  ? 68  PRO   A CG  1 
ATOM   32   C  CD  . PRO   A 1 7   ? 5.793   -1.792  -6.057  1.00 38.70  ? 68  PRO   A CD  1 
ATOM   33   N  N   . GLY   A 1 8   ? 4.699   -6.325  -6.857  1.00 39.34  ? 69  GLY   A N   1 
ATOM   34   C  CA  . GLY   A 1 8   ? 4.212   -7.531  -6.224  1.00 38.79  ? 69  GLY   A CA  1 
ATOM   35   C  C   . GLY   A 1 8   ? 5.302   -8.254  -5.449  1.00 38.88  ? 69  GLY   A C   1 
ATOM   36   O  O   . GLY   A 1 8   ? 6.446   -7.813  -5.349  1.00 43.19  ? 69  GLY   A O   1 
ATOM   37   N  N   . LEU   A 1 9   ? 4.929   -9.402  -4.896  1.00 31.94  ? 70  LEU   A N   1 
ATOM   38   C  CA  . LEU   A 1 9   ? 5.863   -10.220 -4.139  1.00 33.70  ? 70  LEU   A CA  1 
ATOM   39   C  C   . LEU   A 1 9   ? 5.659   -11.674 -4.534  1.00 40.38  ? 70  LEU   A C   1 
ATOM   40   O  O   . LEU   A 1 9   ? 4.519   -12.132 -4.642  1.00 43.18  ? 70  LEU   A O   1 
ATOM   41   C  CB  . LEU   A 1 9   ? 5.665   -10.025 -2.631  1.00 34.36  ? 70  LEU   A CB  1 
ATOM   42   C  CG  . LEU   A 1 9   ? 6.219   -8.728  -2.036  1.00 35.34  ? 70  LEU   A CG  1 
ATOM   43   C  CD1 . LEU   A 1 9   ? 5.804   -8.597  -0.582  1.00 26.72  ? 70  LEU   A CD1 1 
ATOM   44   C  CD2 . LEU   A 1 9   ? 7.732   -8.674  -2.169  1.00 30.99  ? 70  LEU   A CD2 1 
ATOM   45   N  N   . VAL   A 1 10  ? 6.763   -12.390 -4.767  1.00 47.43  ? 71  VAL   A N   1 
ATOM   46   C  CA  . VAL   A 1 10  ? 6.676   -13.804 -5.112  1.00 46.37  ? 71  VAL   A CA  1 
ATOM   47   C  C   . VAL   A 1 10  ? 6.236   -14.607 -3.900  1.00 35.71  ? 71  VAL   A C   1 
ATOM   48   O  O   . VAL   A 1 10  ? 6.601   -14.307 -2.759  1.00 37.69  ? 71  VAL   A O   1 
ATOM   49   C  CB  . VAL   A 1 10  ? 8.019   -14.339 -5.638  1.00 36.38  ? 71  VAL   A CB  1 
ATOM   50   C  CG1 . VAL   A 1 10  ? 8.195   -13.996 -7.098  1.00 45.43  ? 71  VAL   A CG1 1 
ATOM   51   C  CG2 . VAL   A 1 10  ? 9.143   -13.783 -4.813  1.00 36.72  ? 71  VAL   A CG2 1 
ATOM   52   N  N   . ASN   A 1 11  ? 5.478   -15.665 -4.156  1.00 37.93  ? 72  ASN   A N   1 
ATOM   53   C  CA  . ASN   A 1 11  ? 5.071   -16.608 -3.119  1.00 47.28  ? 72  ASN   A CA  1 
ATOM   54   C  C   . ASN   A 1 11  ? 5.295   -18.014 -3.662  1.00 48.05  ? 72  ASN   A C   1 
ATOM   55   O  O   . ASN   A 1 11  ? 4.496   -18.510 -4.462  1.00 57.64  ? 72  ASN   A O   1 
ATOM   56   C  CB  . ASN   A 1 11  ? 3.621   -16.388 -2.720  1.00 49.08  ? 72  ASN   A CB  1 
ATOM   57   C  CG  . ASN   A 1 11  ? 3.238   -17.147 -1.472  1.00 48.52  ? 72  ASN   A CG  1 
ATOM   58   O  OD1 . ASN   A 1 11  ? 4.018   -17.951 -0.950  1.00 47.54  ? 72  ASN   A OD1 1 
ATOM   59   N  ND2 . ASN   A 1 11  ? 2.025   -16.896 -0.983  1.00 41.35  ? 72  ASN   A ND2 1 
ATOM   60   N  N   . LEU   A 1 12  ? 6.381   -18.651 -3.224  1.00 56.20  ? 73  LEU   A N   1 
ATOM   61   C  CA  . LEU   A 1 12  ? 6.668   -20.007 -3.682  1.00 60.43  ? 73  LEU   A CA  1 
ATOM   62   C  C   . LEU   A 1 12  ? 5.597   -20.989 -3.224  1.00 67.54  ? 73  LEU   A C   1 
ATOM   63   O  O   . LEU   A 1 12  ? 5.337   -21.988 -3.906  1.00 69.94  ? 73  LEU   A O   1 
ATOM   64   C  CB  . LEU   A 1 12  ? 8.050   -20.447 -3.190  1.00 59.94  ? 73  LEU   A CB  1 
ATOM   65   C  CG  . LEU   A 1 12  ? 9.278   -19.774 -3.831  1.00 62.97  ? 73  LEU   A CG  1 
ATOM   66   C  CD1 . LEU   A 1 12  ? 9.147   -19.638 -5.354  1.00 42.74  ? 73  LEU   A CD1 1 
ATOM   67   C  CD2 . LEU   A 1 12  ? 9.574   -18.418 -3.188  1.00 59.59  ? 73  LEU   A CD2 1 
ATOM   68   N  N   . GLY   A 1 13  ? 4.961   -20.716 -2.086  1.00 57.82  ? 74  GLY   A N   1 
ATOM   69   C  CA  . GLY   A 1 13  ? 3.894   -21.555 -1.592  1.00 62.20  ? 74  GLY   A CA  1 
ATOM   70   C  C   . GLY   A 1 13  ? 3.478   -21.240 -0.173  1.00 56.39  ? 74  GLY   A C   1 
ATOM   71   O  O   . GLY   A 1 13  ? 2.290   -21.327 0.147   1.00 57.76  ? 74  GLY   A O   1 
ATOM   72   N  N   . ASN   A 1 14  ? 4.421   -20.873 0.699   1.00 47.36  ? 75  ASN   A N   1 
ATOM   73   C  CA  . ASN   A 1 14  ? 4.002   -20.661 2.080   1.00 60.49  ? 75  ASN   A CA  1 
ATOM   74   C  C   . ASN   A 1 14  ? 4.534   -19.357 2.677   1.00 49.73  ? 75  ASN   A C   1 
ATOM   75   O  O   . ASN   A 1 14  ? 4.639   -19.247 3.906   1.00 51.44  ? 75  ASN   A O   1 
ATOM   76   C  CB  . ASN   A 1 14  ? 4.410   -21.867 2.954   1.00 56.42  ? 75  ASN   A CB  1 
ATOM   77   N  N   . THR   A 1 15  ? 4.841   -18.361 1.853   1.00 31.54  ? 76  THR   A N   1 
ATOM   78   C  CA  . THR   A 1 15  ? 5.296   -17.078 2.354   1.00 38.93  ? 76  THR   A CA  1 
ATOM   79   C  C   . THR   A 1 15  ? 4.316   -15.947 1.989   1.00 48.34  ? 76  THR   A C   1 
ATOM   80   O  O   . THR   A 1 15  ? 4.508   -14.783 2.361   1.00 48.82  ? 76  THR   A O   1 
ATOM   81   C  CB  . THR   A 1 15  ? 6.706   -16.755 1.810   1.00 47.85  ? 76  THR   A CB  1 
ATOM   82   O  OG1 . THR   A 1 15  ? 6.644   -16.548 0.396   1.00 51.46  ? 76  THR   A OG1 1 
ATOM   83   C  CG2 . THR   A 1 15  ? 7.659   -17.903 2.097   1.00 58.76  ? 76  THR   A CG2 1 
ATOM   84   N  N   . CYS   A 1 16  ? 2.945   -16.165 2.343   1.00 39.75  ? 77  CYS   A N   1 
ATOM   85   C  CA  . CYS   A 1 16  ? 1.867   -15.200 2.188   1.00 39.08  ? 77  CYS   A CA  1 
ATOM   86   C  C   . CYS   A 1 16  ? 1.755   -14.323 3.395   1.00 36.53  ? 77  CYS   A C   1 
ATOM   87   O  O   . CYS   A 1 16  ? 1.565   -13.092 3.226   1.00 39.76  ? 77  CYS   A O   1 
ATOM   88   C  CB  . CYS   A 1 16  ? 0.547   -15.802 1.767   1.00 33.61  ? 77  CYS   A CB  1 
ATOM   89   S  SG  . CYS   A 1 16  ? -0.134  -17.105 2.858   1.00 43.66  ? 77  CYS   A SG  1 
ATOM   90   N  N   . PHE   A 1 17  ? 2.107   -15.052 4.574   1.00 34.12  ? 78  PHE   A N   1 
ATOM   91   C  CA  . PHE   A 1 17  ? 2.008   -14.419 5.883   1.00 37.71  ? 78  PHE   A CA  1 
ATOM   92   C  C   . PHE   A 1 17  ? 3.020   -13.291 5.956   1.00 35.52  ? 78  PHE   A C   1 
ATOM   93   O  O   . PHE   A 1 17  ? 2.847   -12.325 6.687   1.00 35.50  ? 78  PHE   A O   1 
ATOM   94   C  CB  . PHE   A 1 17  ? 2.261   -15.432 6.993   1.00 33.22  ? 78  PHE   A CB  1 
ATOM   95   C  CG  . PHE   A 1 17  ? 3.687   -15.850 7.080   1.00 37.83  ? 78  PHE   A CG  1 
ATOM   96   C  CD1 . PHE   A 1 17  ? 4.529   -15.311 8.032   1.00 32.16  ? 78  PHE   A CD1 1 
ATOM   97   C  CD2 . PHE   A 1 17  ? 4.201   -16.753 6.167   1.00 37.13  ? 78  PHE   A CD2 1 
ATOM   98   C  CE1 . PHE   A 1 17  ? 5.861   -15.686 8.082   1.00 45.95  ? 78  PHE   A CE1 1 
ATOM   99   C  CE2 . PHE   A 1 17  ? 5.518   -17.126 6.209   1.00 35.63  ? 78  PHE   A CE2 1 
ATOM   100  C  CZ  . PHE   A 1 17  ? 6.352   -16.598 7.167   1.00 39.05  ? 78  PHE   A CZ  1 
ATOM   101  N  N   . MET   A 1 18  ? 4.096   -13.426 5.192   1.00 38.68  ? 79  MET   A N   1 
ATOM   102  C  CA  . MET   A 1 18  ? 5.094   -12.371 5.161   1.00 38.07  ? 79  MET   A CA  1 
ATOM   103  C  C   . MET   A 1 18  ? 4.821   -11.348 4.069   1.00 34.35  ? 79  MET   A C   1 
ATOM   104  O  O   . MET   A 1 18  ? 4.986   -10.144 4.297   1.00 26.56  ? 79  MET   A O   1 
ATOM   105  C  CB  . MET   A 1 18  ? 6.480   -12.964 4.969   1.00 38.17  ? 79  MET   A CB  1 
ATOM   106  C  CG  . MET   A 1 18  ? 7.575   -11.939 5.095   1.00 40.89  ? 79  MET   A CG  1 
ATOM   107  S  SD  . MET   A 1 18  ? 9.148   -12.768 5.073   1.00 53.75  ? 79  MET   A SD  1 
ATOM   108  C  CE  . MET   A 1 18  ? 9.807   -12.085 3.573   1.00 55.94  ? 79  MET   A CE  1 
ATOM   109  N  N   . ASN   A 1 19  ? 4.412   -11.799 2.880   1.00 34.76  ? 80  ASN   A N   1 
ATOM   110  C  CA  . ASN   A 1 19  ? 4.073   -10.844 1.830   1.00 40.49  ? 80  ASN   A CA  1 
ATOM   111  C  C   . ASN   A 1 19  ? 2.918   -9.943  2.243   1.00 34.59  ? 80  ASN   A C   1 
ATOM   112  O  O   . ASN   A 1 19  ? 2.904   -8.755  1.905   1.00 33.77  ? 80  ASN   A O   1 
ATOM   113  C  CB  . ASN   A 1 19  ? 3.736   -11.573 0.535   1.00 34.07  ? 80  ASN   A CB  1 
ATOM   114  C  CG  . ASN   A 1 19  ? 4.947   -12.208 -0.088  1.00 37.31  ? 80  ASN   A CG  1 
ATOM   115  O  OD1 . ASN   A 1 19  ? 6.077   -11.871 0.257   1.00 33.69  ? 80  ASN   A OD1 1 
ATOM   116  N  ND2 . ASN   A 1 19  ? 4.724   -13.123 -1.021  1.00 38.94  ? 80  ASN   A ND2 1 
ATOM   117  N  N   . SER   A 1 20  ? 1.948   -10.480 2.977   1.00 30.22  ? 81  SER   A N   1 
ATOM   118  C  CA  . SER   A 1 20  ? 0.828   -9.653  3.398   1.00 27.79  ? 81  SER   A CA  1 
ATOM   119  C  C   . SER   A 1 20  ? 1.264   -8.614  4.425   1.00 31.22  ? 81  SER   A C   1 
ATOM   120  O  O   . SER   A 1 20  ? 0.864   -7.448  4.337   1.00 27.82  ? 81  SER   A O   1 
ATOM   121  C  CB  . SER   A 1 20  ? -0.277  -10.534 3.959   1.00 28.32  ? 81  SER   A CB  1 
ATOM   122  O  OG  . SER   A 1 20  ? 0.178   -11.145 5.147   1.00 42.67  ? 81  SER   A OG  1 
ATOM   123  N  N   . LEU   A 1 21  ? 2.084   -9.015  5.403   1.00 30.26  ? 82  LEU   A N   1 
ATOM   124  C  CA  . LEU   A 1 21  ? 2.596   -8.057  6.379   1.00 29.05  ? 82  LEU   A CA  1 
ATOM   125  C  C   . LEU   A 1 21  ? 3.499   -7.018  5.726   1.00 26.04  ? 82  LEU   A C   1 
ATOM   126  O  O   . LEU   A 1 21  ? 3.421   -5.832  6.060   1.00 30.19  ? 82  LEU   A O   1 
ATOM   127  C  CB  . LEU   A 1 21  ? 3.352   -8.781  7.491   1.00 33.50  ? 82  LEU   A CB  1 
ATOM   128  C  CG  . LEU   A 1 21  ? 3.905   -7.926  8.637   1.00 30.82  ? 82  LEU   A CG  1 
ATOM   129  C  CD1 . LEU   A 1 21  ? 2.784   -7.374  9.496   1.00 31.43  ? 82  LEU   A CD1 1 
ATOM   130  C  CD2 . LEU   A 1 21  ? 4.872   -8.734  9.484   1.00 32.10  ? 82  LEU   A CD2 1 
ATOM   131  N  N   . LEU   A 1 22  ? 4.367   -7.438  4.802   1.00 23.72  ? 83  LEU   A N   1 
ATOM   132  C  CA  . LEU   A 1 22  ? 5.290   -6.485  4.191   1.00 29.22  ? 83  LEU   A CA  1 
ATOM   133  C  C   . LEU   A 1 22  ? 4.541   -5.424  3.395   1.00 34.89  ? 83  LEU   A C   1 
ATOM   134  O  O   . LEU   A 1 22  ? 4.892   -4.236  3.446   1.00 30.30  ? 83  LEU   A O   1 
ATOM   135  C  CB  . LEU   A 1 22  ? 6.295   -7.208  3.296   1.00 26.18  ? 83  LEU   A CB  1 
ATOM   136  C  CG  . LEU   A 1 22  ? 7.464   -7.887  4.006   1.00 33.95  ? 83  LEU   A CG  1 
ATOM   137  C  CD1 . LEU   A 1 22  ? 8.401   -8.445  2.979   1.00 38.12  ? 83  LEU   A CD1 1 
ATOM   138  C  CD2 . LEU   A 1 22  ? 8.198   -6.930  4.947   1.00 24.07  ? 83  LEU   A CD2 1 
ATOM   139  N  N   . GLN   A 1 23  ? 3.508   -5.840  2.654   1.00 28.43  ? 84  GLN   A N   1 
ATOM   140  C  CA  . GLN   A 1 23  ? 2.693   -4.901  1.892   1.00 27.57  ? 84  GLN   A CA  1 
ATOM   141  C  C   . GLN   A 1 23  ? 2.010   -3.889  2.800   1.00 34.84  ? 84  GLN   A C   1 
ATOM   142  O  O   . GLN   A 1 23  ? 1.938   -2.700  2.461   1.00 32.20  ? 84  GLN   A O   1 
ATOM   143  C  CB  . GLN   A 1 23  ? 1.655   -5.662  1.070   1.00 32.00  ? 84  GLN   A CB  1 
ATOM   144  C  CG  . GLN   A 1 23  ? 2.214   -6.417  -0.122  1.00 27.13  ? 84  GLN   A CG  1 
ATOM   145  C  CD  . GLN   A 1 23  ? 2.572   -5.495  -1.276  1.00 32.06  ? 84  GLN   A CD  1 
ATOM   146  O  OE1 . GLN   A 1 23  ? 2.262   -4.298  -1.248  1.00 28.98  ? 84  GLN   A OE1 1 
ATOM   147  N  NE2 . GLN   A 1 23  ? 3.239   -6.048  -2.299  1.00 32.89  ? 84  GLN   A NE2 1 
ATOM   148  N  N   . GLY   A 1 24  ? 1.518   -4.334  3.952   1.00 30.40  ? 85  GLY   A N   1 
ATOM   149  C  CA  . GLY   A 1 24  ? 0.937   -3.445  4.938   1.00 33.70  ? 85  GLY   A CA  1 
ATOM   150  C  C   . GLY   A 1 24  ? 1.936   -2.547  5.643   1.00 40.79  ? 85  GLY   A C   1 
ATOM   151  O  O   . GLY   A 1 24  ? 1.627   -1.382  5.910   1.00 38.35  ? 85  GLY   A O   1 
ATOM   152  N  N   . LEU   A 1 25  ? 3.132   -3.062  5.957   1.00 33.15  ? 86  LEU   A N   1 
ATOM   153  C  CA  . LEU   A 1 25  ? 4.134   -2.232  6.624   1.00 30.23  ? 86  LEU   A CA  1 
ATOM   154  C  C   . LEU   A 1 25  ? 4.671   -1.145  5.699   1.00 38.09  ? 86  LEU   A C   1 
ATOM   155  O  O   . LEU   A 1 25  ? 5.093   -0.083  6.174   1.00 38.85  ? 86  LEU   A O   1 
ATOM   156  C  CB  . LEU   A 1 25  ? 5.282   -3.096  7.140   1.00 27.54  ? 86  LEU   A CB  1 
ATOM   157  C  CG  . LEU   A 1 25  ? 5.004   -3.945  8.387   1.00 32.44  ? 86  LEU   A CG  1 
ATOM   158  C  CD1 . LEU   A 1 25  ? 6.123   -4.950  8.615   1.00 32.94  ? 86  LEU   A CD1 1 
ATOM   159  C  CD2 . LEU   A 1 25  ? 4.810   -3.087  9.629   1.00 26.39  ? 86  LEU   A CD2 1 
ATOM   160  N  N   . SER   A 1 26  ? 4.660   -1.386  4.385   1.00 39.62  ? 87  SER   A N   1 
ATOM   161  C  CA  . SER   A 1 26  ? 5.103   -0.380  3.429   1.00 41.35  ? 87  SER   A CA  1 
ATOM   162  C  C   . SER   A 1 26  ? 4.098   0.753   3.273   1.00 40.65  ? 87  SER   A C   1 
ATOM   163  O  O   . SER   A 1 26  ? 4.409   1.751   2.617   1.00 43.62  ? 87  SER   A O   1 
ATOM   164  C  CB  . SER   A 1 26  ? 5.366   -1.034  2.070   1.00 34.10  ? 87  SER   A CB  1 
ATOM   165  O  OG  . SER   A 1 26  ? 4.169   -1.612  1.578   1.00 50.56  ? 87  SER   A OG  1 
ATOM   166  N  N   . ALA   A 1 27  ? 2.908   0.624   3.852   1.00 33.19  ? 88  ALA   A N   1 
ATOM   167  C  CA  . ALA   A 1 27  ? 1.891   1.663   3.783   1.00 39.30  ? 88  ALA   A CA  1 
ATOM   168  C  C   . ALA   A 1 27  ? 1.985   2.678   4.921   1.00 35.74  ? 88  ALA   A C   1 
ATOM   169  O  O   . ALA   A 1 27  ? 1.279   3.690   4.887   1.00 31.78  ? 88  ALA   A O   1 
ATOM   170  C  CB  . ALA   A 1 27  ? 0.493   1.023   3.765   1.00 32.92  ? 88  ALA   A CB  1 
ATOM   171  N  N   . CYS   A 1 28  ? 2.841   2.440   5.916   1.00 36.44  ? 89  CYS   A N   1 
ATOM   172  C  CA  . CYS   A 1 28  ? 3.010   3.346   7.043   1.00 46.14  ? 89  CYS   A CA  1 
ATOM   173  C  C   . CYS   A 1 28  ? 4.286   4.159   6.824   1.00 42.76  ? 89  CYS   A C   1 
ATOM   174  O  O   . CYS   A 1 28  ? 5.390   3.656   7.102   1.00 51.41  ? 89  CYS   A O   1 
ATOM   175  C  CB  . CYS   A 1 28  ? 3.094   2.549   8.350   1.00 44.04  ? 89  CYS   A CB  1 
ATOM   176  S  SG  . CYS   A 1 28  ? 1.830   1.221   8.554   1.00 44.18  ? 89  CYS   A SG  1 
ATOM   177  N  N   . PRO   A 1 29  ? 4.208   5.406   6.341   1.00 40.84  ? 90  PRO   A N   1 
ATOM   178  C  CA  . PRO   A 1 29  ? 5.450   6.100   5.957   1.00 45.01  ? 90  PRO   A CA  1 
ATOM   179  C  C   . PRO   A 1 29  ? 6.412   6.356   7.113   1.00 39.76  ? 90  PRO   A C   1 
ATOM   180  O  O   . PRO   A 1 29  ? 7.620   6.433   6.865   1.00 37.76  ? 90  PRO   A O   1 
ATOM   181  C  CB  . PRO   A 1 29  ? 4.959   7.431   5.372   1.00 42.08  ? 90  PRO   A CB  1 
ATOM   182  C  CG  . PRO   A 1 29  ? 3.524   7.259   5.091   1.00 32.32  ? 90  PRO   A CG  1 
ATOM   183  C  CD  . PRO   A 1 29  ? 3.030   6.270   6.135   1.00 41.40  ? 90  PRO   A CD  1 
ATOM   184  N  N   . ALA   A 1 30  ? 5.918   6.465   8.361   1.00 38.15  ? 91  ALA   A N   1 
ATOM   185  C  CA  . ALA   A 1 30  ? 6.746   6.755   9.531   1.00 33.48  ? 91  ALA   A CA  1 
ATOM   186  C  C   . ALA   A 1 30  ? 7.594   5.573   9.942   1.00 34.13  ? 91  ALA   A C   1 
ATOM   187  O  O   . ALA   A 1 30  ? 8.723   5.762   10.394  1.00 36.63  ? 91  ALA   A O   1 
ATOM   188  C  CB  . ALA   A 1 30  ? 5.854   7.166   10.704  1.00 40.72  ? 91  ALA   A CB  1 
ATOM   189  N  N   . PHE   A 1 31  ? 7.098   4.354   9.747   1.00 33.96  ? 92  PHE   A N   1 
ATOM   190  C  CA  . PHE   A 1 31  ? 7.945   3.201   10.007  1.00 35.44  ? 92  PHE   A CA  1 
ATOM   191  C  C   . PHE   A 1 31  ? 9.137   3.193   9.065   1.00 28.76  ? 92  PHE   A C   1 
ATOM   192  O  O   . PHE   A 1 31  ? 10.285  3.009   9.493   1.00 32.02  ? 92  PHE   A O   1 
ATOM   193  C  CB  . PHE   A 1 31  ? 7.123   1.922   9.885   1.00 34.24  ? 92  PHE   A CB  1 
ATOM   194  C  CG  . PHE   A 1 31  ? 7.876   0.695   10.257  1.00 35.92  ? 92  PHE   A CG  1 
ATOM   195  C  CD1 . PHE   A 1 31  ? 8.394   0.541   11.535  1.00 30.76  ? 92  PHE   A CD1 1 
ATOM   196  C  CD2 . PHE   A 1 31  ? 8.056   -0.319  9.335   1.00 34.88  ? 92  PHE   A CD2 1 
ATOM   197  C  CE1 . PHE   A 1 31  ? 9.072   -0.602  11.880  1.00 27.12  ? 92  PHE   A CE1 1 
ATOM   198  C  CE2 . PHE   A 1 31  ? 8.741   -1.464  9.676   1.00 35.97  ? 92  PHE   A CE2 1 
ATOM   199  C  CZ  . PHE   A 1 31  ? 9.248   -1.605  10.949  1.00 30.64  ? 92  PHE   A CZ  1 
ATOM   200  N  N   . ILE   A 1 32  ? 8.882   3.458   7.788   1.00 32.48  ? 93  ILE   A N   1 
ATOM   201  C  CA  . ILE   A 1 32  ? 9.953   3.498   6.807   1.00 42.70  ? 93  ILE   A CA  1 
ATOM   202  C  C   . ILE   A 1 32  ? 10.929  4.623   7.130   1.00 35.32  ? 93  ILE   A C   1 
ATOM   203  O  O   . ILE   A 1 32  ? 12.146  4.428   7.086   1.00 36.38  ? 93  ILE   A O   1 
ATOM   204  C  CB  . ILE   A 1 32  ? 9.355   3.620   5.396   1.00 39.58  ? 93  ILE   A CB  1 
ATOM   205  C  CG1 . ILE   A 1 32  ? 8.298   2.525   5.179   1.00 38.03  ? 93  ILE   A CG1 1 
ATOM   206  C  CG2 . ILE   A 1 32  ? 10.435  3.505   4.376   1.00 35.41  ? 93  ILE   A CG2 1 
ATOM   207  C  CD1 . ILE   A 1 32  ? 7.615   2.574   3.823   1.00 48.96  ? 93  ILE   A CD1 1 
ATOM   208  N  N   . ARG   A 1 33  ? 10.415  5.794   7.522   1.00 38.64  ? 94  ARG   A N   1 
ATOM   209  C  CA  . ARG   A 1 33  ? 11.279  6.914   7.899   1.00 39.11  ? 94  ARG   A CA  1 
ATOM   210  C  C   . ARG   A 1 33  ? 12.103  6.594   9.143   1.00 41.12  ? 94  ARG   A C   1 
ATOM   211  O  O   . ARG   A 1 33  ? 13.262  7.011   9.256   1.00 41.25  ? 94  ARG   A O   1 
ATOM   212  C  CB  . ARG   A 1 33  ? 10.426  8.162   8.134   1.00 39.24  ? 94  ARG   A CB  1 
ATOM   213  C  CG  . ARG   A 1 33  ? 11.054  9.481   7.730   1.00 50.94  ? 94  ARG   A CG  1 
ATOM   214  C  CD  . ARG   A 1 33  ? 10.006  10.370  7.058   1.00 58.74  ? 94  ARG   A CD  1 
ATOM   215  N  NE  . ARG   A 1 33  ? 8.684   10.252  7.681   1.00 53.02  ? 94  ARG   A NE  1 
ATOM   216  C  CZ  . ARG   A 1 33  ? 7.529   10.351  7.021   1.00 63.82  ? 94  ARG   A CZ  1 
ATOM   217  N  NH1 . ARG   A 1 33  ? 7.527   10.563  5.707   1.00 57.47  ? 94  ARG   A NH1 1 
ATOM   218  N  NH2 . ARG   A 1 33  ? 6.374   10.235  7.676   1.00 49.28  ? 94  ARG   A NH2 1 
ATOM   219  N  N   . TRP   A 1 34  ? 11.519  5.869   10.097  1.00 35.11  ? 95  TRP   A N   1 
ATOM   220  C  CA  . TRP   A 1 34  ? 12.287  5.474   11.268  1.00 33.84  ? 95  TRP   A CA  1 
ATOM   221  C  C   . TRP   A 1 34  ? 13.354  4.449   10.908  1.00 38.35  ? 95  TRP   A C   1 
ATOM   222  O  O   . TRP   A 1 34  ? 14.444  4.465   11.487  1.00 37.96  ? 95  TRP   A O   1 
ATOM   223  C  CB  . TRP   A 1 34  ? 11.354  4.931   12.346  1.00 32.43  ? 95  TRP   A CB  1 
ATOM   224  C  CG  . TRP   A 1 34  ? 12.071  4.424   13.542  1.00 31.74  ? 95  TRP   A CG  1 
ATOM   225  C  CD1 . TRP   A 1 34  ? 12.433  5.136   14.651  1.00 34.63  ? 95  TRP   A CD1 1 
ATOM   226  C  CD2 . TRP   A 1 34  ? 12.530  3.090   13.753  1.00 31.61  ? 95  TRP   A CD2 1 
ATOM   227  N  NE1 . TRP   A 1 34  ? 13.089  4.321   15.542  1.00 30.75  ? 95  TRP   A NE1 1 
ATOM   228  C  CE2 . TRP   A 1 34  ? 13.162  3.059   15.014  1.00 31.25  ? 95  TRP   A CE2 1 
ATOM   229  C  CE3 . TRP   A 1 34  ? 12.457  1.913   13.004  1.00 30.80  ? 95  TRP   A CE3 1 
ATOM   230  C  CZ2 . TRP   A 1 34  ? 13.713  1.898   15.541  1.00 26.44  ? 95  TRP   A CZ2 1 
ATOM   231  C  CZ3 . TRP   A 1 34  ? 13.002  0.762   13.529  1.00 36.01  ? 95  TRP   A CZ3 1 
ATOM   232  C  CH2 . TRP   A 1 34  ? 13.627  0.764   14.787  1.00 36.62  ? 95  TRP   A CH2 1 
ATOM   233  N  N   . LEU   A 1 35  ? 13.070  3.566   9.947   1.00 38.85  ? 96  LEU   A N   1 
ATOM   234  C  CA  . LEU   A 1 35  ? 14.083  2.610   9.515   1.00 40.56  ? 96  LEU   A CA  1 
ATOM   235  C  C   . LEU   A 1 35  ? 15.265  3.312   8.853   1.00 44.00  ? 96  LEU   A C   1 
ATOM   236  O  O   . LEU   A 1 35  ? 16.421  2.955   9.108   1.00 40.17  ? 96  LEU   A O   1 
ATOM   237  C  CB  . LEU   A 1 35  ? 13.469  1.583   8.568   1.00 39.74  ? 96  LEU   A CB  1 
ATOM   238  C  CG  . LEU   A 1 35  ? 12.986  0.299   9.237   1.00 42.04  ? 96  LEU   A CG  1 
ATOM   239  C  CD1 . LEU   A 1 35  ? 12.576  -0.700  8.176   1.00 38.76  ? 96  LEU   A CD1 1 
ATOM   240  C  CD2 . LEU   A 1 35  ? 14.057  -0.285  10.146  1.00 40.74  ? 96  LEU   A CD2 1 
ATOM   241  N  N   . GLU   A 1 36  ? 14.995  4.312   8.004   1.00 44.27  ? 97  GLU   A N   1 
ATOM   242  C  CA  . GLU   A 1 36  ? 16.078  5.041   7.344   1.00 48.22  ? 97  GLU   A CA  1 
ATOM   243  C  C   . GLU   A 1 36  ? 17.008  5.690   8.361   1.00 39.08  ? 97  GLU   A C   1 
ATOM   244  O  O   . GLU   A 1 36  ? 18.231  5.519   8.293   1.00 38.50  ? 97  GLU   A O   1 
ATOM   245  C  CB  . GLU   A 1 36  ? 15.509  6.093   6.393   1.00 39.45  ? 97  GLU   A CB  1 
ATOM   246  C  CG  . GLU   A 1 36  ? 15.082  5.515   5.064   1.00 53.95  ? 97  GLU   A CG  1 
ATOM   247  C  CD  . GLU   A 1 36  ? 15.533  6.346   3.865   1.00 68.19  ? 97  GLU   A CD  1 
ATOM   248  O  OE1 . GLU   A 1 36  ? 14.666  7.017   3.255   1.00 62.77  ? 97  GLU   A OE1 1 
ATOM   249  O  OE2 . GLU   A 1 36  ? 16.743  6.313   3.526   1.00 59.45  ? 97  GLU   A OE2 1 
ATOM   250  N  N   . GLU   A 1 37  ? 16.443  6.436   9.315   1.00 37.31  ? 98  GLU   A N   1 
ATOM   251  C  CA  . GLU   A 1 37  ? 17.257  7.104   10.320  1.00 39.57  ? 98  GLU   A CA  1 
ATOM   252  C  C   . GLU   A 1 37  ? 17.947  6.122   11.247  1.00 44.13  ? 98  GLU   A C   1 
ATOM   253  O  O   . GLU   A 1 37  ? 18.945  6.484   11.875  1.00 38.70  ? 98  GLU   A O   1 
ATOM   254  C  CB  . GLU   A 1 37  ? 16.404  8.090   11.125  1.00 40.82  ? 98  GLU   A CB  1 
ATOM   255  C  CG  . GLU   A 1 37  ? 15.836  9.214   10.271  1.00 57.97  ? 98  GLU   A CG  1 
ATOM   256  C  CD  . GLU   A 1 37  ? 14.637  9.910   10.904  1.00 64.33  ? 98  GLU   A CD  1 
ATOM   257  O  OE1 . GLU   A 1 37  ? 14.071  10.797  10.231  1.00 63.90  ? 98  GLU   A OE1 1 
ATOM   258  O  OE2 . GLU   A 1 37  ? 14.266  9.590   12.060  1.00 65.72  ? 98  GLU   A OE2 1 
ATOM   259  N  N   . PHE   A 1 38  ? 17.439  4.894   11.350  1.00 50.60  ? 99  PHE   A N   1 
ATOM   260  C  CA  . PHE   A 1 38  ? 18.100  3.868   12.153  1.00 48.31  ? 99  PHE   A CA  1 
ATOM   261  C  C   . PHE   A 1 38  ? 19.274  3.242   11.404  1.00 50.56  ? 99  PHE   A C   1 
ATOM   262  O  O   . PHE   A 1 38  ? 20.332  3.000   11.995  1.00 56.50  ? 99  PHE   A O   1 
ATOM   263  C  CB  . PHE   A 1 38  ? 17.087  2.794   12.559  1.00 46.44  ? 99  PHE   A CB  1 
ATOM   264  C  CG  . PHE   A 1 38  ? 17.660  1.698   13.402  1.00 54.95  ? 99  PHE   A CG  1 
ATOM   265  C  CD1 . PHE   A 1 38  ? 18.125  1.963   14.679  1.00 61.07  ? 99  PHE   A CD1 1 
ATOM   266  C  CD2 . PHE   A 1 38  ? 17.718  0.396   12.924  1.00 56.36  ? 99  PHE   A CD2 1 
ATOM   267  C  CE1 . PHE   A 1 38  ? 18.651  0.955   15.462  1.00 64.30  ? 99  PHE   A CE1 1 
ATOM   268  C  CE2 . PHE   A 1 38  ? 18.241  -0.624  13.709  1.00 59.50  ? 99  PHE   A CE2 1 
ATOM   269  C  CZ  . PHE   A 1 38  ? 18.708  -0.342  14.980  1.00 68.23  ? 99  PHE   A CZ  1 
ATOM   270  N  N   . THR   A 1 39  ? 19.110  2.980   10.106  1.00 48.97  ? 100 THR   A N   1 
ATOM   271  C  CA  . THR   A 1 39  ? 20.198  2.439   9.305   1.00 50.76  ? 100 THR   A CA  1 
ATOM   272  C  C   . THR   A 1 39  ? 21.224  3.493   8.921   1.00 58.84  ? 100 THR   A C   1 
ATOM   273  O  O   . THR   A 1 39  ? 22.238  3.146   8.307   1.00 67.82  ? 100 THR   A O   1 
ATOM   274  C  CB  . THR   A 1 39  ? 19.656  1.772   8.036   1.00 48.26  ? 100 THR   A CB  1 
ATOM   275  O  OG1 . THR   A 1 39  ? 18.955  2.736   7.236   1.00 44.71  ? 100 THR   A OG1 1 
ATOM   276  C  CG2 . THR   A 1 39  ? 18.721  0.634   8.397   1.00 48.38  ? 100 THR   A CG2 1 
ATOM   277  N  N   . SER   A 1 40  ? 20.985  4.764   9.256   1.00 60.66  ? 101 SER   A N   1 
ATOM   278  C  CA  . SER   A 1 40  ? 21.983  5.795   9.000   1.00 53.15  ? 101 SER   A CA  1 
ATOM   279  C  C   . SER   A 1 40  ? 23.275  5.506   9.749   1.00 59.99  ? 101 SER   A C   1 
ATOM   280  O  O   . SER   A 1 40  ? 24.348  5.945   9.319   1.00 71.06  ? 101 SER   A O   1 
ATOM   281  C  CB  . SER   A 1 40  ? 21.429  7.165   9.398   1.00 44.54  ? 101 SER   A CB  1 
ATOM   282  O  OG  . SER   A 1 40  ? 21.052  7.166   10.763  1.00 56.44  ? 101 SER   A OG  1 
ATOM   283  N  N   . GLN   A 1 41  ? 23.187  4.775   10.868  1.00 59.58  ? 102 GLN   A N   1 
ATOM   284  C  CA  . GLN   A 1 41  ? 24.374  4.443   11.652  1.00 63.31  ? 102 GLN   A CA  1 
ATOM   285  C  C   . GLN   A 1 41  ? 25.325  3.538   10.878  1.00 70.55  ? 102 GLN   A C   1 
ATOM   286  O  O   . GLN   A 1 41  ? 26.547  3.638   11.030  1.00 79.72  ? 102 GLN   A O   1 
ATOM   287  C  CB  . GLN   A 1 41  ? 23.952  3.806   12.990  1.00 67.39  ? 102 GLN   A CB  1 
ATOM   288  C  CG  . GLN   A 1 41  ? 23.419  2.362   12.931  1.00 83.24  ? 102 GLN   A CG  1 
ATOM   289  C  CD  . GLN   A 1 41  ? 22.988  1.837   14.300  1.00 85.83  ? 102 GLN   A CD  1 
ATOM   290  O  OE1 . GLN   A 1 41  ? 22.940  2.593   15.262  1.00 90.50  ? 102 GLN   A OE1 1 
ATOM   291  N  NE2 . GLN   A 1 41  ? 22.695  0.538   14.393  1.00 89.59  ? 102 GLN   A NE2 1 
ATOM   292  N  N   . TYR   A 1 42  ? 24.790  2.653   10.048  1.00 70.30  ? 103 TYR   A N   1 
ATOM   293  C  CA  . TYR   A 1 42  ? 25.623  1.759   9.257   1.00 70.47  ? 103 TYR   A CA  1 
ATOM   294  C  C   . TYR   A 1 42  ? 26.246  2.446   8.045   1.00 70.67  ? 103 TYR   A C   1 
ATOM   295  O  O   . TYR   A 1 42  ? 27.281  1.986   7.549   1.00 67.11  ? 103 TYR   A O   1 
ATOM   296  C  CB  . TYR   A 1 42  ? 24.799  0.545   8.807   1.00 67.35  ? 103 TYR   A CB  1 
ATOM   297  C  CG  . TYR   A 1 42  ? 24.197  -0.235  9.961   1.00 62.20  ? 103 TYR   A CG  1 
ATOM   298  C  CD1 . TYR   A 1 42  ? 24.888  -0.384  11.155  1.00 46.41  ? 103 TYR   A CD1 1 
ATOM   299  C  CD2 . TYR   A 1 42  ? 22.937  -0.799  9.861   1.00 59.38  ? 103 TYR   A CD2 1 
ATOM   300  C  CE1 . TYR   A 1 42  ? 24.350  -1.088  12.202  1.00 65.96  ? 103 TYR   A CE1 1 
ATOM   301  C  CE2 . TYR   A 1 42  ? 22.385  -1.500  10.908  1.00 61.31  ? 103 TYR   A CE2 1 
ATOM   302  C  CZ  . TYR   A 1 42  ? 23.093  -1.642  12.080  1.00 73.28  ? 103 TYR   A CZ  1 
ATOM   303  O  OH  . TYR   A 1 42  ? 22.548  -2.345  13.138  1.00 75.91  ? 103 TYR   A OH  1 
ATOM   304  N  N   . SER   A 1 43  ? 25.658  3.536   7.567   1.00 74.88  ? 104 SER   A N   1 
ATOM   305  C  CA  . SER   A 1 43  ? 26.172  4.252   6.412   1.00 74.62  ? 104 SER   A CA  1 
ATOM   306  C  C   . SER   A 1 43  ? 27.160  5.343   6.790   1.00 79.44  ? 104 SER   A C   1 
ATOM   307  O  O   . SER   A 1 43  ? 27.541  6.136   5.926   1.00 86.79  ? 104 SER   A O   1 
ATOM   308  C  CB  . SER   A 1 43  ? 25.016  4.856   5.608   1.00 77.85  ? 104 SER   A CB  1 
ATOM   309  N  N   . ARG   A 1 44  ? 27.585  5.403   8.055   1.00 83.70  ? 105 ARG   A N   1 
ATOM   310  C  CA  . ARG   A 1 44  ? 28.577  6.398   8.459   1.00 86.19  ? 105 ARG   A CA  1 
ATOM   311  C  C   . ARG   A 1 44  ? 29.925  6.130   7.794   1.00 86.09  ? 105 ARG   A C   1 
ATOM   312  O  O   . ARG   A 1 44  ? 30.576  7.052   7.284   1.00 77.27  ? 105 ARG   A O   1 
ATOM   313  C  CB  . ARG   A 1 44  ? 28.711  6.414   9.983   1.00 71.00  ? 105 ARG   A CB  1 
ATOM   314  N  N   . ASP   A 1 45  ? 30.358  4.872   7.790   1.00 86.88  ? 106 ASP   A N   1 
ATOM   315  C  CA  . ASP   A 1 45  ? 31.556  4.431   7.087   1.00 81.54  ? 106 ASP   A CA  1 
ATOM   316  C  C   . ASP   A 1 45  ? 31.129  3.593   5.889   1.00 86.89  ? 106 ASP   A C   1 
ATOM   317  O  O   . ASP   A 1 45  ? 30.570  2.503   6.060   1.00 78.03  ? 106 ASP   A O   1 
ATOM   318  C  CB  . ASP   A 1 45  ? 32.465  3.624   8.013   1.00 64.30  ? 106 ASP   A CB  1 
ATOM   319  N  N   . GLN   A 1 46  ? 31.399  4.102   4.686   1.00 89.99  ? 107 GLN   A N   1 
ATOM   320  C  CA  . GLN   A 1 46  ? 30.965  3.489   3.425   1.00 88.49  ? 107 GLN   A CA  1 
ATOM   321  C  C   . GLN   A 1 46  ? 29.441  3.475   3.425   1.00 94.91  ? 107 GLN   A C   1 
ATOM   322  O  O   . GLN   A 1 46  ? 28.836  4.557   3.523   1.00 100.79 ? 107 GLN   A O   1 
ATOM   323  C  CB  . GLN   A 1 46  ? 31.642  2.129   3.249   1.00 97.28  ? 107 GLN   A CB  1 
ATOM   324  N  N   . LYS   A 1 47  ? 28.785  2.321   3.320   1.00 92.47  ? 108 LYS   A N   1 
ATOM   325  C  CA  . LYS   A 1 47  ? 27.328  2.289   3.310   1.00 88.62  ? 108 LYS   A CA  1 
ATOM   326  C  C   . LYS   A 1 47  ? 26.804  1.001   3.935   1.00 93.08  ? 108 LYS   A C   1 
ATOM   327  O  O   . LYS   A 1 47  ? 25.599  0.870   4.177   1.00 96.18  ? 108 LYS   A O   1 
ATOM   328  C  CB  . LYS   A 1 47  ? 26.801  2.444   1.881   1.00 74.74  ? 108 LYS   A CB  1 
ATOM   329  N  N   . GLU   A 1 48  ? 27.707  0.054   4.210   1.00 92.58  ? 109 GLU   A N   1 
ATOM   330  C  CA  . GLU   A 1 48  ? 27.378  -1.275  4.720   1.00 87.87  ? 109 GLU   A CA  1 
ATOM   331  C  C   . GLU   A 1 48  ? 26.314  -1.953  3.862   1.00 95.40  ? 109 GLU   A C   1 
ATOM   332  O  O   . GLU   A 1 48  ? 25.174  -2.125  4.313   1.00 89.95  ? 109 GLU   A O   1 
ATOM   333  C  CB  . GLU   A 1 48  ? 26.907  -1.196  6.173   1.00 78.55  ? 109 GLU   A CB  1 
ATOM   334  N  N   . PRO   A 1 49  ? 26.641  -2.352  2.634   1.00 102.13 ? 110 PRO   A N   1 
ATOM   335  C  CA  . PRO   A 1 49  ? 25.651  -3.031  1.772   1.00 100.06 ? 110 PRO   A CA  1 
ATOM   336  C  C   . PRO   A 1 49  ? 25.136  -4.334  2.368   1.00 94.50  ? 110 PRO   A C   1 
ATOM   337  O  O   . PRO   A 1 49  ? 24.035  -4.776  2.001   1.00 92.29  ? 110 PRO   A O   1 
ATOM   338  C  CB  . PRO   A 1 49  ? 26.423  -3.280  0.462   1.00 95.51  ? 110 PRO   A CB  1 
ATOM   339  C  CG  . PRO   A 1 49  ? 27.857  -2.941  0.748   1.00 100.83 ? 110 PRO   A CG  1 
ATOM   340  C  CD  . PRO   A 1 49  ? 27.852  -1.974  1.884   1.00 97.23  ? 110 PRO   A CD  1 
ATOM   341  N  N   . PRO   A 1 50  ? 25.895  -5.014  3.259   1.00 93.64  ? 111 PRO   A N   1 
ATOM   342  C  CA  . PRO   A 1 50  ? 25.199  -6.131  3.918   1.00 88.65  ? 111 PRO   A CA  1 
ATOM   343  C  C   . PRO   A 1 50  ? 23.954  -5.715  4.702   1.00 81.89  ? 111 PRO   A C   1 
ATOM   344  O  O   . PRO   A 1 50  ? 22.851  -6.155  4.367   1.00 77.00  ? 111 PRO   A O   1 
ATOM   345  C  CB  . PRO   A 1 50  ? 26.267  -6.684  4.862   1.00 92.04  ? 111 PRO   A CB  1 
ATOM   346  C  CG  . PRO   A 1 50  ? 27.525  -6.469  4.117   1.00 95.03  ? 111 PRO   A CG  1 
ATOM   347  C  CD  . PRO   A 1 50  ? 27.358  -5.123  3.451   1.00 94.67  ? 111 PRO   A CD  1 
ATOM   348  N  N   . GLN   A 1 53  ? 23.702  -8.706  6.220   1.00 62.79  ? 114 GLN   A N   1 
ATOM   349  C  CA  . GLN   A 1 53  ? 23.873  -9.314  7.537   1.00 77.53  ? 114 GLN   A CA  1 
ATOM   350  C  C   . GLN   A 1 53  ? 23.092  -8.546  8.599   1.00 71.17  ? 114 GLN   A C   1 
ATOM   351  O  O   . GLN   A 1 53  ? 23.215  -8.819  9.796   1.00 67.56  ? 114 GLN   A O   1 
ATOM   352  C  CB  . GLN   A 1 53  ? 25.359  -9.376  7.917   1.00 63.91  ? 114 GLN   A CB  1 
ATOM   353  N  N   . TYR   A 1 54  ? 22.287  -7.583  8.158   1.00 62.10  ? 115 TYR   A N   1 
ATOM   354  C  CA  . TYR   A 1 54  ? 21.499  -6.752  9.056   1.00 63.00  ? 115 TYR   A CA  1 
ATOM   355  C  C   . TYR   A 1 54  ? 20.024  -6.858  8.692   1.00 59.69  ? 115 TYR   A C   1 
ATOM   356  O  O   . TYR   A 1 54  ? 19.665  -6.853  7.509   1.00 59.28  ? 115 TYR   A O   1 
ATOM   357  C  CB  . TYR   A 1 54  ? 21.963  -5.294  9.003   1.00 56.58  ? 115 TYR   A CB  1 
ATOM   358  N  N   . LEU   A 1 55  ? 19.171  -6.971  9.717   1.00 58.03  ? 116 LEU   A N   1 
ATOM   359  C  CA  . LEU   A 1 55  ? 17.737  -7.098  9.474   1.00 48.66  ? 116 LEU   A CA  1 
ATOM   360  C  C   . LEU   A 1 55  ? 17.127  -5.766  9.055   1.00 53.61  ? 116 LEU   A C   1 
ATOM   361  O  O   . LEU   A 1 55  ? 16.286  -5.720  8.149   1.00 50.73  ? 116 LEU   A O   1 
ATOM   362  C  CB  . LEU   A 1 55  ? 17.031  -7.649  10.718  1.00 46.03  ? 116 LEU   A CB  1 
ATOM   363  C  CG  . LEU   A 1 55  ? 15.492  -7.598  10.709  1.00 47.98  ? 116 LEU   A CG  1 
ATOM   364  C  CD1 . LEU   A 1 55  ? 14.886  -8.717  9.887   1.00 44.62  ? 116 LEU   A CD1 1 
ATOM   365  C  CD2 . LEU   A 1 55  ? 14.916  -7.615  12.114  1.00 47.34  ? 116 LEU   A CD2 1 
ATOM   366  N  N   . SER   A 1 56  ? 17.536  -4.672  9.704   1.00 51.83  ? 117 SER   A N   1 
ATOM   367  C  CA  . SER   A 1 56  ? 16.979  -3.364  9.377   1.00 43.99  ? 117 SER   A CA  1 
ATOM   368  C  C   . SER   A 1 56  ? 17.300  -2.961  7.942   1.00 42.80  ? 117 SER   A C   1 
ATOM   369  O  O   . SER   A 1 56  ? 16.461  -2.366  7.258   1.00 41.41  ? 117 SER   A O   1 
ATOM   370  C  CB  . SER   A 1 56  ? 17.508  -2.318  10.351  1.00 45.31  ? 117 SER   A CB  1 
ATOM   371  O  OG  . SER   A 1 56  ? 18.916  -2.421  10.457  1.00 53.45  ? 117 SER   A OG  1 
ATOM   372  N  N   . LEU   A 1 57  ? 18.512  -3.257  7.470   1.00 48.18  ? 118 LEU   A N   1 
ATOM   373  C  CA  . LEU   A 1 57  ? 18.851  -2.906  6.095   1.00 51.60  ? 118 LEU   A CA  1 
ATOM   374  C  C   . LEU   A 1 57  ? 18.031  -3.719  5.104   1.00 47.79  ? 118 LEU   A C   1 
ATOM   375  O  O   . LEU   A 1 57  ? 17.584  -3.192  4.079   1.00 45.86  ? 118 LEU   A O   1 
ATOM   376  C  CB  . LEU   A 1 57  ? 20.343  -3.111  5.852   1.00 45.78  ? 118 LEU   A CB  1 
ATOM   377  C  CG  . LEU   A 1 57  ? 21.225  -2.066  6.520   1.00 46.79  ? 118 LEU   A CG  1 
ATOM   378  C  CD1 . LEU   A 1 57  ? 22.653  -2.558  6.575   1.00 58.78  ? 118 LEU   A CD1 1 
ATOM   379  C  CD2 . LEU   A 1 57  ? 21.126  -0.746  5.776   1.00 35.77  ? 118 LEU   A CD2 1 
ATOM   380  N  N   . THR   A 1 58  ? 17.823  -5.005  5.397   1.00 43.85  ? 119 THR   A N   1 
ATOM   381  C  CA  . THR   A 1 58  ? 17.054  -5.858  4.498   1.00 41.57  ? 119 THR   A CA  1 
ATOM   382  C  C   . THR   A 1 58  ? 15.588  -5.464  4.483   1.00 44.99  ? 119 THR   A C   1 
ATOM   383  O  O   . THR   A 1 58  ? 14.947  -5.490  3.426   1.00 42.45  ? 119 THR   A O   1 
ATOM   384  C  CB  . THR   A 1 58  ? 17.192  -7.317  4.917   1.00 50.92  ? 119 THR   A CB  1 
ATOM   385  O  OG1 . THR   A 1 58  ? 18.571  -7.604  5.186   1.00 59.81  ? 119 THR   A OG1 1 
ATOM   386  C  CG2 . THR   A 1 58  ? 16.688  -8.245  3.827   1.00 38.15  ? 119 THR   A CG2 1 
ATOM   387  N  N   . LEU   A 1 59  ? 15.049  -5.086  5.641   1.00 40.06  ? 120 LEU   A N   1 
ATOM   388  C  CA  . LEU   A 1 59  ? 13.648  -4.705  5.715   1.00 30.63  ? 120 LEU   A CA  1 
ATOM   389  C  C   . LEU   A 1 59  ? 13.403  -3.370  5.025   1.00 35.76  ? 120 LEU   A C   1 
ATOM   390  O  O   . LEU   A 1 59  ? 12.415  -3.211  4.298   1.00 39.99  ? 120 LEU   A O   1 
ATOM   391  C  CB  . LEU   A 1 59  ? 13.224  -4.651  7.176   1.00 29.92  ? 120 LEU   A CB  1 
ATOM   392  C  CG  . LEU   A 1 59  ? 11.801  -4.211  7.456   1.00 34.30  ? 120 LEU   A CG  1 
ATOM   393  C  CD1 . LEU   A 1 59  ? 10.824  -5.118  6.717   1.00 36.22  ? 120 LEU   A CD1 1 
ATOM   394  C  CD2 . LEU   A 1 59  ? 11.606  -4.293  8.951   1.00 43.34  ? 120 LEU   A CD2 1 
ATOM   395  N  N   . LEU   A 1 60  ? 14.306  -2.409  5.222   1.00 33.46  ? 121 LEU   A N   1 
ATOM   396  C  CA  . LEU   A 1 60  ? 14.112  -1.071  4.679   1.00 38.61  ? 121 LEU   A CA  1 
ATOM   397  C  C   . LEU   A 1 60  ? 14.075  -1.091  3.156   1.00 38.97  ? 121 LEU   A C   1 
ATOM   398  O  O   . LEU   A 1 60  ? 13.199  -0.477  2.537   1.00 36.08  ? 121 LEU   A O   1 
ATOM   399  C  CB  . LEU   A 1 60  ? 15.222  -0.145  5.174   1.00 45.65  ? 121 LEU   A CB  1 
ATOM   400  C  CG  . LEU   A 1 60  ? 15.295  1.224   4.500   1.00 45.96  ? 121 LEU   A CG  1 
ATOM   401  C  CD1 . LEU   A 1 60  ? 13.991  1.977   4.722   1.00 36.65  ? 121 LEU   A CD1 1 
ATOM   402  C  CD2 . LEU   A 1 60  ? 16.492  2.024   5.014   1.00 50.17  ? 121 LEU   A CD2 1 
ATOM   403  N  N   . HIS   A 1 61  ? 15.025  -1.777  2.528   1.00 37.08  ? 122 HIS   A N   1 
ATOM   404  C  CA  . HIS   A 1 61  ? 15.026  -1.754  1.074   1.00 42.96  ? 122 HIS   A CA  1 
ATOM   405  C  C   . HIS   A 1 61  ? 13.840  -2.518  0.498   1.00 41.85  ? 122 HIS   A C   1 
ATOM   406  O  O   . HIS   A 1 61  ? 13.398  -2.210  -0.614  1.00 36.63  ? 122 HIS   A O   1 
ATOM   407  C  CB  . HIS   A 1 61  ? 16.359  -2.278  0.549   1.00 54.37  ? 122 HIS   A CB  1 
ATOM   408  C  CG  . HIS   A 1 61  ? 17.504  -1.350  0.821   1.00 70.29  ? 122 HIS   A CG  1 
ATOM   409  N  ND1 . HIS   A 1 61  ? 18.710  -1.780  1.334   1.00 70.83  ? 122 HIS   A ND1 1 
ATOM   410  C  CD2 . HIS   A 1 61  ? 17.620  -0.008  0.667   1.00 70.20  ? 122 HIS   A CD2 1 
ATOM   411  C  CE1 . HIS   A 1 61  ? 19.521  -0.747  1.478   1.00 56.23  ? 122 HIS   A CE1 1 
ATOM   412  N  NE2 . HIS   A 1 61  ? 18.884  0.340   1.080   1.00 77.98  ? 122 HIS   A NE2 1 
ATOM   413  N  N   . LEU   A 1 62  ? 13.280  -3.466  1.246   1.00 38.92  ? 123 LEU   A N   1 
ATOM   414  C  CA  . LEU   A 1 62  ? 12.031  -4.076  0.810   1.00 31.56  ? 123 LEU   A CA  1 
ATOM   415  C  C   . LEU   A 1 62  ? 10.875  -3.088  0.918   1.00 35.83  ? 123 LEU   A C   1 
ATOM   416  O  O   . LEU   A 1 62  ? 10.108  -2.916  -0.036  1.00 34.28  ? 123 LEU   A O   1 
ATOM   417  C  CB  . LEU   A 1 62  ? 11.751  -5.334  1.631   1.00 34.94  ? 123 LEU   A CB  1 
ATOM   418  C  CG  . LEU   A 1 62  ? 12.129  -6.636  0.932   1.00 39.67  ? 123 LEU   A CG  1 
ATOM   419  C  CD1 . LEU   A 1 62  ? 11.230  -6.835  -0.270  1.00 36.80  ? 123 LEU   A CD1 1 
ATOM   420  C  CD2 . LEU   A 1 62  ? 13.604  -6.621  0.511   1.00 54.01  ? 123 LEU   A CD2 1 
ATOM   421  N  N   . LEU   A 1 63  ? 10.746  -2.421  2.068   1.00 32.97  ? 124 LEU   A N   1 
ATOM   422  C  CA  . LEU   A 1 63  ? 9.663   -1.465  2.246   1.00 28.97  ? 124 LEU   A CA  1 
ATOM   423  C  C   . LEU   A 1 63  ? 9.837   -0.246  1.351   1.00 32.61  ? 124 LEU   A C   1 
ATOM   424  O  O   . LEU   A 1 63  ? 8.841   0.329   0.899   1.00 29.21  ? 124 LEU   A O   1 
ATOM   425  C  CB  . LEU   A 1 63  ? 9.566   -1.046  3.711   1.00 27.81  ? 124 LEU   A CB  1 
ATOM   426  C  CG  . LEU   A 1 63  ? 9.379   -2.184  4.712   1.00 33.43  ? 124 LEU   A CG  1 
ATOM   427  C  CD1 . LEU   A 1 63  ? 9.157   -1.615  6.095   1.00 32.29  ? 124 LEU   A CD1 1 
ATOM   428  C  CD2 . LEU   A 1 63  ? 8.223   -3.103  4.308   1.00 34.64  ? 124 LEU   A CD2 1 
ATOM   429  N  N   . LYS   A 1 64  ? 11.080  0.157   1.067   1.00 32.61  ? 125 LYS   A N   1 
ATOM   430  C  CA  . LYS   A 1 64  ? 11.275  1.303   0.181   1.00 33.41  ? 125 LYS   A CA  1 
ATOM   431  C  C   . LYS   A 1 64  ? 10.902  0.966   -1.260  1.00 35.94  ? 125 LYS   A C   1 
ATOM   432  O  O   . LYS   A 1 64  ? 10.386  1.828   -1.983  1.00 38.86  ? 125 LYS   A O   1 
ATOM   433  C  CB  . LYS   A 1 64  ? 12.716  1.806   0.268   1.00 25.88  ? 125 LYS   A CB  1 
ATOM   434  N  N   . ALA   A 1 65  ? 11.122  -0.278  -1.693  1.00 33.09  ? 126 ALA   A N   1 
ATOM   435  C  CA  . ALA   A 1 65  ? 10.689  -0.672  -3.031  1.00 35.89  ? 126 ALA   A CA  1 
ATOM   436  C  C   . ALA   A 1 65  ? 9.185   -0.900  -3.103  1.00 40.83  ? 126 ALA   A C   1 
ATOM   437  O  O   . ALA   A 1 65  ? 8.568   -0.621  -4.138  1.00 45.41  ? 126 ALA   A O   1 
ATOM   438  C  CB  . ALA   A 1 65  ? 11.428  -1.930  -3.483  1.00 30.36  ? 126 ALA   A CB  1 
ATOM   439  N  N   . LEU   A 1 66  ? 8.576   -1.391  -2.024  1.00 35.44  ? 127 LEU   A N   1 
ATOM   440  C  CA  . LEU   A 1 66  ? 7.139   -1.620  -2.029  1.00 34.49  ? 127 LEU   A CA  1 
ATOM   441  C  C   . LEU   A 1 66  ? 6.347   -0.326  -1.918  1.00 39.30  ? 127 LEU   A C   1 
ATOM   442  O  O   . LEU   A 1 66  ? 5.218   -0.257  -2.417  1.00 43.72  ? 127 LEU   A O   1 
ATOM   443  C  CB  . LEU   A 1 66  ? 6.757   -2.564  -0.897  1.00 25.95  ? 127 LEU   A CB  1 
ATOM   444  C  CG  . LEU   A 1 66  ? 7.132   -4.002  -1.202  1.00 32.43  ? 127 LEU   A CG  1 
ATOM   445  C  CD1 . LEU   A 1 66  ? 6.820   -4.859  0.002   1.00 33.78  ? 127 LEU   A CD1 1 
ATOM   446  C  CD2 . LEU   A 1 66  ? 6.368   -4.458  -2.425  1.00 36.52  ? 127 LEU   A CD2 1 
ATOM   447  N  N   . SER   A 1 67  ? 6.896   0.697   -1.268  1.00 34.12  ? 128 SER   A N   1 
ATOM   448  C  CA  . SER   A 1 67  ? 6.218   1.988   -1.222  1.00 38.20  ? 128 SER   A CA  1 
ATOM   449  C  C   . SER   A 1 67  ? 6.591   2.888   -2.393  1.00 39.95  ? 128 SER   A C   1 
ATOM   450  O  O   . SER   A 1 67  ? 6.278   4.082   -2.358  1.00 39.82  ? 128 SER   A O   1 
ATOM   451  C  CB  . SER   A 1 67  ? 6.512   2.719   0.092   1.00 36.80  ? 128 SER   A CB  1 
ATOM   452  O  OG  . SER   A 1 67  ? 7.870   3.107   0.171   1.00 37.32  ? 128 SER   A OG  1 
ATOM   453  N  N   . CYS   A 1 68  ? 7.270   2.347   -3.405  1.00 40.86  ? 129 CYS   A N   1 
ATOM   454  C  CA  . CYS   A 1 68  ? 7.570   3.071   -4.639  1.00 40.45  ? 129 CYS   A CA  1 
ATOM   455  C  C   . CYS   A 1 68  ? 8.460   4.285   -4.373  1.00 49.28  ? 129 CYS   A C   1 
ATOM   456  O  O   . CYS   A 1 68  ? 8.354   5.313   -5.045  1.00 56.18  ? 129 CYS   A O   1 
ATOM   457  C  CB  . CYS   A 1 68  ? 6.282   3.476   -5.361  1.00 36.50  ? 129 CYS   A CB  1 
ATOM   458  S  SG  . CYS   A 1 68  ? 5.407   2.079   -6.095  1.00 54.81  ? 129 CYS   A SG  1 
ATOM   459  N  N   . GLN   A 1 69  ? 9.347   4.166   -3.381  1.00 45.94  ? 130 GLN   A N   1 
ATOM   460  C  CA  . GLN   A 1 69  ? 10.332  5.204   -3.105  1.00 44.74  ? 130 GLN   A CA  1 
ATOM   461  C  C   . GLN   A 1 69  ? 11.677  4.934   -3.763  1.00 48.80  ? 130 GLN   A C   1 
ATOM   462  O  O   . GLN   A 1 69  ? 12.491  5.858   -3.883  1.00 58.21  ? 130 GLN   A O   1 
ATOM   463  C  CB  . GLN   A 1 69  ? 10.542  5.353   -1.597  1.00 48.41  ? 130 GLN   A CB  1 
ATOM   464  C  CG  . GLN   A 1 69  ? 9.322   5.831   -0.827  1.00 43.43  ? 130 GLN   A CG  1 
ATOM   465  C  CD  . GLN   A 1 69  ? 9.646   6.125   0.630   1.00 44.69  ? 130 GLN   A CD  1 
ATOM   466  O  OE1 . GLN   A 1 69  ? 10.814  6.174   1.026   1.00 48.08  ? 130 GLN   A OE1 1 
ATOM   467  N  NE2 . GLN   A 1 69  ? 8.608   6.310   1.439   1.00 51.37  ? 130 GLN   A NE2 1 
ATOM   468  N  N   . GLU   A 1 70  ? 11.937  3.695   -4.166  1.00 51.30  ? 131 GLU   A N   1 
ATOM   469  C  CA  . GLU   A 1 70  ? 13.119  3.338   -4.936  1.00 53.74  ? 131 GLU   A CA  1 
ATOM   470  C  C   . GLU   A 1 70  ? 12.664  2.759   -6.269  1.00 48.10  ? 131 GLU   A C   1 
ATOM   471  O  O   . GLU   A 1 70  ? 11.707  1.982   -6.319  1.00 57.02  ? 131 GLU   A O   1 
ATOM   472  C  CB  . GLU   A 1 70  ? 14.002  2.335   -4.173  1.00 37.81  ? 131 GLU   A CB  1 
ATOM   473  N  N   . VAL   A 1 71  ? 13.339  3.153   -7.347  1.00 52.23  ? 132 VAL   A N   1 
ATOM   474  C  CA  . VAL   A 1 71  ? 12.929  2.750   -8.691  1.00 64.60  ? 132 VAL   A CA  1 
ATOM   475  C  C   . VAL   A 1 71  ? 13.123  1.246   -8.842  1.00 63.02  ? 132 VAL   A C   1 
ATOM   476  O  O   . VAL   A 1 71  ? 14.226  0.725   -8.644  1.00 74.17  ? 132 VAL   A O   1 
ATOM   477  C  CB  . VAL   A 1 71  ? 13.714  3.518   -9.765  1.00 63.46  ? 132 VAL   A CB  1 
ATOM   478  C  CG1 . VAL   A 1 71  ? 13.206  3.148   -11.156 1.00 63.84  ? 132 VAL   A CG1 1 
ATOM   479  C  CG2 . VAL   A 1 71  ? 13.634  5.032   -9.540  1.00 54.51  ? 132 VAL   A CG2 1 
ATOM   480  N  N   . THR   A 1 72  ? 12.052  0.541   -9.203  1.00 56.65  ? 133 THR   A N   1 
ATOM   481  C  CA  . THR   A 1 72  ? 12.077  -0.909  -9.372  1.00 69.91  ? 133 THR   A CA  1 
ATOM   482  C  C   . THR   A 1 72  ? 11.613  -1.262  -10.776 1.00 65.43  ? 133 THR   A C   1 
ATOM   483  O  O   . THR   A 1 72  ? 10.482  -0.945  -11.157 1.00 69.98  ? 133 THR   A O   1 
ATOM   484  C  CB  . THR   A 1 72  ? 11.188  -1.614  -8.344  1.00 71.16  ? 133 THR   A CB  1 
ATOM   485  O  OG1 . THR   A 1 72  ? 11.707  -1.399  -7.026  1.00 72.64  ? 133 THR   A OG1 1 
ATOM   486  C  CG2 . THR   A 1 72  ? 11.158  -3.098  -8.622  1.00 60.88  ? 133 THR   A CG2 1 
ATOM   487  N  N   . ASP   A 1 73  ? 12.469  -1.945  -11.530 1.00 63.74  ? 134 ASP   A N   1 
ATOM   488  C  CA  . ASP   A 1 73  ? 12.104  -2.366  -12.875 1.00 68.50  ? 134 ASP   A CA  1 
ATOM   489  C  C   . ASP   A 1 73  ? 11.491  -3.757  -12.915 1.00 64.14  ? 134 ASP   A C   1 
ATOM   490  O  O   . ASP   A 1 73  ? 10.714  -4.052  -13.830 1.00 57.91  ? 134 ASP   A O   1 
ATOM   491  C  CB  . ASP   A 1 73  ? 13.322  -2.305  -13.794 1.00 63.85  ? 134 ASP   A CB  1 
ATOM   492  C  CG  . ASP   A 1 73  ? 13.318  -1.067  -14.654 1.00 80.50  ? 134 ASP   A CG  1 
ATOM   493  O  OD1 . ASP   A 1 73  ? 12.272  -0.812  -15.291 1.00 82.06  ? 134 ASP   A OD1 1 
ATOM   494  O  OD2 . ASP   A 1 73  ? 14.340  -0.350  -14.684 1.00 82.75  ? 134 ASP   A OD2 1 
ATOM   495  N  N   . ASP   A 1 74  ? 11.818  -4.615  -11.952 1.00 60.93  ? 135 ASP   A N   1 
ATOM   496  C  CA  . ASP   A 1 74  ? 11.129  -5.892  -11.819 1.00 60.52  ? 135 ASP   A CA  1 
ATOM   497  C  C   . ASP   A 1 74  ? 9.723   -5.651  -11.282 1.00 71.38  ? 135 ASP   A C   1 
ATOM   498  O  O   . ASP   A 1 74  ? 9.559   -5.104  -10.188 1.00 73.40  ? 135 ASP   A O   1 
ATOM   499  C  CB  . ASP   A 1 74  ? 11.903  -6.819  -10.884 1.00 56.76  ? 135 ASP   A CB  1 
ATOM   500  C  CG  . ASP   A 1 74  ? 13.172  -7.366  -11.517 1.00 66.49  ? 135 ASP   A CG  1 
ATOM   501  O  OD1 . ASP   A 1 74  ? 13.370  -7.162  -12.736 1.00 57.80  ? 135 ASP   A OD1 1 
ATOM   502  O  OD2 . ASP   A 1 74  ? 13.974  -7.995  -10.789 1.00 57.11  ? 135 ASP   A OD2 1 
ATOM   503  N  N   . GLU   A 1 75  ? 8.705   -6.067  -12.038 1.00 67.36  ? 136 GLU   A N   1 
ATOM   504  C  CA  . GLU   A 1 75  ? 7.327   -5.870  -11.595 1.00 74.15  ? 136 GLU   A CA  1 
ATOM   505  C  C   . GLU   A 1 75  ? 6.977   -6.700  -10.368 1.00 66.80  ? 136 GLU   A C   1 
ATOM   506  O  O   . GLU   A 1 75  ? 5.885   -6.524  -9.813  1.00 60.00  ? 136 GLU   A O   1 
ATOM   507  C  CB  . GLU   A 1 75  ? 6.344   -6.203  -12.719 1.00 73.15  ? 136 GLU   A CB  1 
ATOM   508  C  CG  . GLU   A 1 75  ? 6.864   -5.898  -14.104 1.00 82.88  ? 136 GLU   A CG  1 
ATOM   509  C  CD  . GLU   A 1 75  ? 7.668   -7.051  -14.673 1.00 92.35  ? 136 GLU   A CD  1 
ATOM   510  O  OE1 . GLU   A 1 75  ? 7.706   -8.126  -14.030 1.00 86.51  ? 136 GLU   A OE1 1 
ATOM   511  O  OE2 . GLU   A 1 75  ? 8.272   -6.876  -15.753 1.00 98.49  ? 136 GLU   A OE2 1 
ATOM   512  N  N   . VAL   A 1 76  ? 7.860   -7.597  -9.936  1.00 59.70  ? 137 VAL   A N   1 
ATOM   513  C  CA  . VAL   A 1 76  ? 7.646   -8.389  -8.731  1.00 56.68  ? 137 VAL   A CA  1 
ATOM   514  C  C   . VAL   A 1 76  ? 8.955   -8.441  -7.951  1.00 46.14  ? 137 VAL   A C   1 
ATOM   515  O  O   . VAL   A 1 76  ? 10.032  -8.584  -8.542  1.00 45.36  ? 137 VAL   A O   1 
ATOM   516  C  CB  . VAL   A 1 76  ? 7.122   -9.804  -9.068  1.00 58.53  ? 137 VAL   A CB  1 
ATOM   517  C  CG1 . VAL   A 1 76  ? 7.973   -10.474 -10.152 1.00 62.16  ? 137 VAL   A CG1 1 
ATOM   518  C  CG2 . VAL   A 1 76  ? 7.039   -10.667 -7.818  1.00 55.85  ? 137 VAL   A CG2 1 
ATOM   519  N  N   . LEU   A 1 77  ? 8.865   -8.287  -6.632  1.00 40.79  ? 138 LEU   A N   1 
ATOM   520  C  CA  . LEU   A 1 77  ? 10.010  -8.368  -5.735  1.00 46.88  ? 138 LEU   A CA  1 
ATOM   521  C  C   . LEU   A 1 77  ? 10.034  -9.706  -5.008  1.00 37.03  ? 138 LEU   A C   1 
ATOM   522  O  O   . LEU   A 1 77  ? 9.016   -10.388 -4.874  1.00 43.10  ? 138 LEU   A O   1 
ATOM   523  C  CB  . LEU   A 1 77  ? 9.986   -7.235  -4.709  1.00 43.73  ? 138 LEU   A CB  1 
ATOM   524  C  CG  . LEU   A 1 77  ? 10.376  -5.871  -5.267  1.00 42.26  ? 138 LEU   A CG  1 
ATOM   525  C  CD1 . LEU   A 1 77  ? 9.651   -4.789  -4.490  1.00 41.88  ? 138 LEU   A CD1 1 
ATOM   526  C  CD2 . LEU   A 1 77  ? 11.887  -5.679  -5.244  1.00 38.43  ? 138 LEU   A CD2 1 
ATOM   527  N  N   . ASP   A 1 78  ? 11.221  -10.069 -4.527  1.00 35.40  ? 139 ASP   A N   1 
ATOM   528  C  CA  . ASP   A 1 78  ? 11.448  -11.311 -3.800  1.00 33.92  ? 139 ASP   A CA  1 
ATOM   529  C  C   . ASP   A 1 78  ? 12.000  -10.965 -2.428  1.00 38.76  ? 139 ASP   A C   1 
ATOM   530  O  O   . ASP   A 1 78  ? 13.076  -10.365 -2.319  1.00 40.79  ? 139 ASP   A O   1 
ATOM   531  C  CB  . ASP   A 1 78  ? 12.406  -12.234 -4.561  1.00 42.07  ? 139 ASP   A CB  1 
ATOM   532  C  CG  . ASP   A 1 78  ? 12.781  -13.484 -3.771  1.00 48.98  ? 139 ASP   A CG  1 
ATOM   533  O  OD1 . ASP   A 1 78  ? 13.885  -13.514 -3.190  1.00 48.67  ? 139 ASP   A OD1 1 
ATOM   534  O  OD2 . ASP   A 1 78  ? 11.980  -14.441 -3.727  1.00 59.68  ? 139 ASP   A OD2 1 
ATOM   535  N  N   . ALA   A 1 79  ? 11.266  -11.350 -1.387  1.00 36.02  ? 140 ALA   A N   1 
ATOM   536  C  CA  . ALA   A 1 79  ? 11.591  -10.992 -0.019  1.00 37.25  ? 140 ALA   A CA  1 
ATOM   537  C  C   . ALA   A 1 79  ? 12.278  -12.119 0.724   1.00 41.76  ? 140 ALA   A C   1 
ATOM   538  O  O   . ALA   A 1 79  ? 12.421  -12.042 1.948   1.00 49.35  ? 140 ALA   A O   1 
ATOM   539  C  CB  . ALA   A 1 79  ? 10.325  -10.566 0.725   1.00 31.71  ? 140 ALA   A CB  1 
ATOM   540  N  N   . SER   A 1 80  ? 12.725  -13.153 0.010   1.00 43.84  ? 141 SER   A N   1 
ATOM   541  C  CA  . SER   A 1 80  ? 13.306  -14.313 0.671   1.00 46.57  ? 141 SER   A CA  1 
ATOM   542  C  C   . SER   A 1 80  ? 14.525  -13.961 1.514   1.00 49.50  ? 141 SER   A C   1 
ATOM   543  O  O   . SER   A 1 80  ? 14.790  -14.642 2.505   1.00 52.08  ? 141 SER   A O   1 
ATOM   544  C  CB  . SER   A 1 80  ? 13.659  -15.378 -0.365  1.00 48.97  ? 141 SER   A CB  1 
ATOM   545  O  OG  . SER   A 1 80  ? 12.654  -15.433 -1.361  1.00 55.17  ? 141 SER   A OG  1 
ATOM   546  N  N   . CYS   A 1 81  ? 15.267  -12.911 1.166   1.00 48.54  ? 142 CYS   A N   1 
ATOM   547  C  CA  . CYS   A 1 81  ? 16.417  -12.547 1.984   1.00 45.01  ? 142 CYS   A CA  1 
ATOM   548  C  C   . CYS   A 1 81  ? 15.991  -12.170 3.402   1.00 49.47  ? 142 CYS   A C   1 
ATOM   549  O  O   . CYS   A 1 81  ? 16.717  -12.462 4.360   1.00 52.27  ? 142 CYS   A O   1 
ATOM   550  C  CB  . CYS   A 1 81  ? 17.195  -11.412 1.323   1.00 46.87  ? 142 CYS   A CB  1 
ATOM   551  S  SG  . CYS   A 1 81  ? 17.591  -11.666 -0.451  1.00 68.06  ? 142 CYS   A SG  1 
ATOM   552  N  N   . LEU   A 1 82  ? 14.806  -11.563 3.557   1.00 42.86  ? 143 LEU   A N   1 
ATOM   553  C  CA  . LEU   A 1 82  ? 14.307  -11.221 4.888   1.00 45.08  ? 143 LEU   A CA  1 
ATOM   554  C  C   . LEU   A 1 82  ? 14.059  -12.469 5.725   1.00 48.89  ? 143 LEU   A C   1 
ATOM   555  O  O   . LEU   A 1 82  ? 14.274  -12.468 6.944   1.00 40.99  ? 143 LEU   A O   1 
ATOM   556  C  CB  . LEU   A 1 82  ? 13.023  -10.402 4.770   1.00 36.13  ? 143 LEU   A CB  1 
ATOM   557  C  CG  . LEU   A 1 82  ? 12.188  -10.218 6.030   1.00 24.76  ? 143 LEU   A CG  1 
ATOM   558  C  CD1 . LEU   A 1 82  ? 12.939  -9.359  7.014   1.00 38.30  ? 143 LEU   A CD1 1 
ATOM   559  C  CD2 . LEU   A 1 82  ? 10.881  -9.563  5.659   1.00 53.64  ? 143 LEU   A CD2 1 
ATOM   560  N  N   . LEU   A 1 83  ? 13.596  -13.543 5.090   1.00 49.99  ? 144 LEU   A N   1 
ATOM   561  C  CA  . LEU   A 1 83  ? 13.297  -14.756 5.833   1.00 46.75  ? 144 LEU   A CA  1 
ATOM   562  C  C   . LEU   A 1 83  ? 14.569  -15.465 6.271   1.00 51.44  ? 144 LEU   A C   1 
ATOM   563  O  O   . LEU   A 1 83  ? 14.607  -16.044 7.362   1.00 57.68  ? 144 LEU   A O   1 
ATOM   564  C  CB  . LEU   A 1 83  ? 12.421  -15.669 4.981   1.00 48.10  ? 144 LEU   A CB  1 
ATOM   565  C  CG  . LEU   A 1 83  ? 10.963  -15.719 5.429   1.00 52.36  ? 144 LEU   A CG  1 
ATOM   566  C  CD1 . LEU   A 1 83  ? 10.124  -16.376 4.351   1.00 45.88  ? 144 LEU   A CD1 1 
ATOM   567  C  CD2 . LEU   A 1 83  ? 10.874  -16.481 6.748   1.00 50.37  ? 144 LEU   A CD2 1 
ATOM   568  N  N   . ASP   A 1 84  ? 15.622  -15.414 5.451   1.00 44.24  ? 145 ASP   A N   1 
ATOM   569  C  CA  . ASP   A 1 84  ? 16.864  -16.094 5.803   1.00 53.37  ? 145 ASP   A CA  1 
ATOM   570  C  C   . ASP   A 1 84  ? 17.569  -15.412 6.974   1.00 54.22  ? 145 ASP   A C   1 
ATOM   571  O  O   . ASP   A 1 84  ? 18.110  -16.092 7.853   1.00 58.91  ? 145 ASP   A O   1 
ATOM   572  C  CB  . ASP   A 1 84  ? 17.786  -16.171 4.584   1.00 59.90  ? 145 ASP   A CB  1 
ATOM   573  C  CG  . ASP   A 1 84  ? 17.118  -16.832 3.375   1.00 65.74  ? 145 ASP   A CG  1 
ATOM   574  O  OD1 . ASP   A 1 84  ? 17.445  -16.444 2.228   1.00 58.55  ? 145 ASP   A OD1 1 
ATOM   575  O  OD2 . ASP   A 1 84  ? 16.267  -17.733 3.572   1.00 64.08  ? 145 ASP   A OD2 1 
ATOM   576  N  N   . VAL   A 1 85  ? 17.566  -14.075 7.011   1.00 54.63  ? 146 VAL   A N   1 
ATOM   577  C  CA  . VAL   A 1 85  ? 18.170  -13.345 8.128   1.00 58.60  ? 146 VAL   A CA  1 
ATOM   578  C  C   . VAL   A 1 85  ? 17.398  -13.579 9.423   1.00 58.98  ? 146 VAL   A C   1 
ATOM   579  O  O   . VAL   A 1 85  ? 17.987  -13.596 10.512  1.00 66.60  ? 146 VAL   A O   1 
ATOM   580  C  CB  . VAL   A 1 85  ? 18.263  -11.841 7.797   1.00 55.46  ? 146 VAL   A CB  1 
ATOM   581  C  CG1 . VAL   A 1 85  ? 18.831  -11.055 8.974   1.00 58.20  ? 146 VAL   A CG1 1 
ATOM   582  C  CG2 . VAL   A 1 85  ? 19.110  -11.619 6.557   1.00 43.74  ? 146 VAL   A CG2 1 
ATOM   583  N  N   . LEU   A 1 86  ? 16.078  -13.756 9.338   1.00 58.44  ? 147 LEU   A N   1 
ATOM   584  C  CA  . LEU   A 1 86  ? 15.295  -14.042 10.536  1.00 57.60  ? 147 LEU   A CA  1 
ATOM   585  C  C   . LEU   A 1 86  ? 15.603  -15.430 11.078  1.00 62.09  ? 147 LEU   A C   1 
ATOM   586  O  O   . LEU   A 1 86  ? 15.697  -15.621 12.296  1.00 64.43  ? 147 LEU   A O   1 
ATOM   587  C  CB  . LEU   A 1 86  ? 13.804  -13.911 10.234  1.00 49.17  ? 147 LEU   A CB  1 
ATOM   588  C  CG  . LEU   A 1 86  ? 13.234  -12.497 10.183  1.00 48.12  ? 147 LEU   A CG  1 
ATOM   589  C  CD1 . LEU   A 1 86  ? 11.763  -12.534 9.788   1.00 37.14  ? 147 LEU   A CD1 1 
ATOM   590  C  CD2 . LEU   A 1 86  ? 13.425  -11.803 11.528  1.00 53.31  ? 147 LEU   A CD2 1 
ATOM   591  N  N   . ARG   A 1 87  ? 15.761  -16.412 10.188  1.00 67.07  ? 148 ARG   A N   1 
ATOM   592  C  CA  . ARG   A 1 87  ? 16.039  -17.773 10.632  1.00 80.20  ? 148 ARG   A CA  1 
ATOM   593  C  C   . ARG   A 1 87  ? 17.437  -17.899 11.226  1.00 79.92  ? 148 ARG   A C   1 
ATOM   594  O  O   . ARG   A 1 87  ? 17.674  -18.776 12.066  1.00 93.43  ? 148 ARG   A O   1 
ATOM   595  C  CB  . ARG   A 1 87  ? 15.864  -18.754 9.471   1.00 79.48  ? 148 ARG   A CB  1 
ATOM   596  N  N   . MET   A 1 88  ? 18.372  -17.037 10.815  1.00 71.25  ? 149 MET   A N   1 
ATOM   597  C  CA  . MET   A 1 88  ? 19.728  -17.107 11.350  1.00 77.11  ? 149 MET   A CA  1 
ATOM   598  C  C   . MET   A 1 88  ? 19.834  -16.526 12.756  1.00 73.96  ? 149 MET   A C   1 
ATOM   599  O  O   . MET   A 1 88  ? 20.788  -16.849 13.472  1.00 86.18  ? 149 MET   A O   1 
ATOM   600  C  CB  . MET   A 1 88  ? 20.709  -16.393 10.415  1.00 72.87  ? 149 MET   A CB  1 
ATOM   601  C  CG  . MET   A 1 88  ? 20.900  -17.078 9.061   1.00 62.81  ? 149 MET   A CG  1 
ATOM   602  S  SD  . MET   A 1 88  ? 22.282  -16.380 8.137   1.00 71.42  ? 149 MET   A SD  1 
ATOM   603  C  CE  . MET   A 1 88  ? 21.641  -16.392 6.467   1.00 49.45  ? 149 MET   A CE  1 
ATOM   604  N  N   . TYR   A 1 89  ? 18.890  -15.683 13.169  1.00 64.28  ? 150 TYR   A N   1 
ATOM   605  C  CA  . TYR   A 1 89  ? 18.888  -15.153 14.531  1.00 63.22  ? 150 TYR   A CA  1 
ATOM   606  C  C   . TYR   A 1 89  ? 18.165  -16.112 15.479  1.00 59.73  ? 150 TYR   A C   1 
ATOM   607  O  O   . TYR   A 1 89  ? 17.694  -15.717 16.547  1.00 59.78  ? 150 TYR   A O   1 
ATOM   608  C  CB  . TYR   A 1 89  ? 18.237  -13.767 14.573  1.00 61.35  ? 150 TYR   A CB  1 
ATOM   609  N  N   . ASP   A 1 100 ? 1.500   -17.144 10.651  1.00 27.69  ? 161 ASP   A N   1 
ATOM   610  C  CA  . ASP   A 1 100 ? 0.737   -16.053 11.273  1.00 49.01  ? 161 ASP   A CA  1 
ATOM   611  C  C   . ASP   A 1 100 ? 1.385   -14.677 11.081  1.00 41.58  ? 161 ASP   A C   1 
ATOM   612  O  O   . ASP   A 1 100 ? 2.484   -14.435 11.573  1.00 38.47  ? 161 ASP   A O   1 
ATOM   613  C  CB  . ASP   A 1 100 ? 0.552   -16.301 12.773  1.00 34.39  ? 161 ASP   A CB  1 
ATOM   614  C  CG  . ASP   A 1 100 ? -0.387  -15.288 13.411  1.00 44.54  ? 161 ASP   A CG  1 
ATOM   615  O  OD1 . ASP   A 1 100 ? -1.078  -14.567 12.657  1.00 44.54  ? 161 ASP   A OD1 1 
ATOM   616  O  OD2 . ASP   A 1 100 ? -0.435  -15.203 14.657  1.00 52.39  ? 161 ASP   A OD2 1 
ATOM   617  N  N   . ALA   A 1 101 ? 0.693   -13.759 10.396  1.00 29.16  ? 162 ALA   A N   1 
ATOM   618  C  CA  . ALA   A 1 101 ? 1.306   -12.464 10.118  1.00 34.97  ? 162 ALA   A CA  1 
ATOM   619  C  C   . ALA   A 1 101 ? 1.412   -11.584 11.354  1.00 32.65  ? 162 ALA   A C   1 
ATOM   620  O  O   . ALA   A 1 101 ? 2.191   -10.626 11.348  1.00 38.03  ? 162 ALA   A O   1 
ATOM   621  C  CB  . ALA   A 1 101 ? 0.536   -11.721 9.029   1.00 27.48  ? 162 ALA   A CB  1 
ATOM   622  N  N   . HIS   A 1 102 ? 0.650   -11.873 12.404  1.00 35.56  ? 163 HIS   A N   1 
ATOM   623  C  CA  . HIS   A 1 102 ? 0.766   -11.062 13.606  1.00 35.89  ? 163 HIS   A CA  1 
ATOM   624  C  C   . HIS   A 1 102 ? 2.040   -11.384 14.371  1.00 37.81  ? 163 HIS   A C   1 
ATOM   625  O  O   . HIS   A 1 102 ? 2.766   -10.472 14.781  1.00 44.26  ? 163 HIS   A O   1 
ATOM   626  C  CB  . HIS   A 1 102 ? -0.454  -11.258 14.499  1.00 37.20  ? 163 HIS   A CB  1 
ATOM   627  C  CG  . HIS   A 1 102 ? -0.446  -10.386 15.710  1.00 36.28  ? 163 HIS   A CG  1 
ATOM   628  N  ND1 . HIS   A 1 102 ? -0.624  -10.880 16.982  1.00 41.23  ? 163 HIS   A ND1 1 
ATOM   629  C  CD2 . HIS   A 1 102 ? -0.245  -9.052  15.846  1.00 42.01  ? 163 HIS   A CD2 1 
ATOM   630  C  CE1 . HIS   A 1 102 ? -0.557  -9.885  17.851  1.00 46.79  ? 163 HIS   A CE1 1 
ATOM   631  N  NE2 . HIS   A 1 102 ? -0.325  -8.766  17.187  1.00 46.91  ? 163 HIS   A NE2 1 
ATOM   632  N  N   . GLU   A 1 103 ? 2.335   -12.671 14.565  1.00 39.52  ? 164 GLU   A N   1 
ATOM   633  C  CA  . GLU   A 1 103 ? 3.530   -13.032 15.322  1.00 42.69  ? 164 GLU   A CA  1 
ATOM   634  C  C   . GLU   A 1 103 ? 4.798   -12.627 14.585  1.00 38.93  ? 164 GLU   A C   1 
ATOM   635  O  O   . GLU   A 1 103 ? 5.777   -12.211 15.218  1.00 35.86  ? 164 GLU   A O   1 
ATOM   636  C  CB  . GLU   A 1 103 ? 3.535   -14.530 15.630  1.00 42.02  ? 164 GLU   A CB  1 
ATOM   637  C  CG  . GLU   A 1 103 ? 2.412   -14.956 16.577  1.00 62.72  ? 164 GLU   A CG  1 
ATOM   638  C  CD  . GLU   A 1 103 ? 2.438   -14.204 17.915  1.00 70.16  ? 164 GLU   A CD  1 
ATOM   639  O  OE1 . GLU   A 1 103 ? 3.214   -14.601 18.821  1.00 57.48  ? 164 GLU   A OE1 1 
ATOM   640  O  OE2 . GLU   A 1 103 ? 1.679   -13.214 18.054  1.00 65.03  ? 164 GLU   A OE2 1 
ATOM   641  N  N   . LEU   A 1 104 ? 4.793   -12.730 13.255  1.00 27.79  ? 165 LEU   A N   1 
ATOM   642  C  CA  . LEU   A 1 104 ? 5.898   -12.198 12.472  1.00 35.50  ? 165 LEU   A CA  1 
ATOM   643  C  C   . LEU   A 1 104 ? 6.098   -10.708 12.728  1.00 35.71  ? 165 LEU   A C   1 
ATOM   644  O  O   . LEU   A 1 104 ? 7.238   -10.238 12.801  1.00 37.09  ? 165 LEU   A O   1 
ATOM   645  C  CB  . LEU   A 1 104 ? 5.651   -12.460 10.990  1.00 27.12  ? 165 LEU   A CB  1 
ATOM   646  C  CG  . LEU   A 1 104 ? 6.745   -11.931 10.074  1.00 31.68  ? 165 LEU   A CG  1 
ATOM   647  C  CD1 . LEU   A 1 104 ? 8.035   -12.700 10.307  1.00 23.53  ? 165 LEU   A CD1 1 
ATOM   648  C  CD2 . LEU   A 1 104 ? 6.283   -12.044 8.632   1.00 33.79  ? 165 LEU   A CD2 1 
ATOM   649  N  N   . PHE   A 1 105 ? 5.004   -9.955  12.867  1.00 36.97  ? 166 PHE   A N   1 
ATOM   650  C  CA  . PHE   A 1 105 ? 5.105   -8.542  13.213  1.00 36.93  ? 166 PHE   A CA  1 
ATOM   651  C  C   . PHE   A 1 105 ? 5.806   -8.367  14.551  1.00 36.56  ? 166 PHE   A C   1 
ATOM   652  O  O   . PHE   A 1 105 ? 6.690   -7.515  14.693  1.00 38.11  ? 166 PHE   A O   1 
ATOM   653  C  CB  . PHE   A 1 105 ? 3.705   -7.923  13.234  1.00 30.96  ? 166 PHE   A CB  1 
ATOM   654  C  CG  . PHE   A 1 105 ? 3.647   -6.524  13.796  1.00 31.40  ? 166 PHE   A CG  1 
ATOM   655  C  CD1 . PHE   A 1 105 ? 4.122   -5.447  13.066  1.00 37.69  ? 166 PHE   A CD1 1 
ATOM   656  C  CD2 . PHE   A 1 105 ? 3.065   -6.282  15.028  1.00 38.00  ? 166 PHE   A CD2 1 
ATOM   657  C  CE1 . PHE   A 1 105 ? 4.037   -4.156  13.563  1.00 32.15  ? 166 PHE   A CE1 1 
ATOM   658  C  CE2 . PHE   A 1 105 ? 2.983   -4.993  15.537  1.00 37.51  ? 166 PHE   A CE2 1 
ATOM   659  C  CZ  . PHE   A 1 105 ? 3.472   -3.930  14.802  1.00 38.98  ? 166 PHE   A CZ  1 
ATOM   660  N  N   . HIS   A 1 106 ? 5.442   -9.184  15.539  1.00 37.44  ? 167 HIS   A N   1 
ATOM   661  C  CA  . HIS   A 1 106 ? 6.090   -9.084  16.841  1.00 42.72  ? 167 HIS   A CA  1 
ATOM   662  C  C   . HIS   A 1 106 ? 7.523   -9.592  16.796  1.00 38.91  ? 167 HIS   A C   1 
ATOM   663  O  O   . HIS   A 1 106 ? 8.366   -9.137  17.577  1.00 44.15  ? 167 HIS   A O   1 
ATOM   664  C  CB  . HIS   A 1 106 ? 5.271   -9.837  17.884  1.00 46.78  ? 167 HIS   A CB  1 
ATOM   665  C  CG  . HIS   A 1 106 ? 4.087   -9.067  18.377  1.00 45.52  ? 167 HIS   A CG  1 
ATOM   666  N  ND1 . HIS   A 1 106 ? 4.193   -7.800  18.910  1.00 51.21  ? 167 HIS   A ND1 1 
ATOM   667  C  CD2 . HIS   A 1 106 ? 2.772   -9.380  18.412  1.00 47.92  ? 167 HIS   A CD2 1 
ATOM   668  C  CE1 . HIS   A 1 106 ? 2.994   -7.367  19.257  1.00 44.77  ? 167 HIS   A CE1 1 
ATOM   669  N  NE2 . HIS   A 1 106 ? 2.114   -8.307  18.964  1.00 53.64  ? 167 HIS   A NE2 1 
ATOM   670  N  N   . VAL   A 1 107 ? 7.816   -10.522 15.886  1.00 40.56  ? 168 VAL   A N   1 
ATOM   671  C  CA  . VAL   A 1 107 ? 9.186   -10.991 15.718  1.00 40.04  ? 168 VAL   A CA  1 
ATOM   672  C  C   . VAL   A 1 107 ? 10.048  -9.895  15.106  1.00 34.04  ? 168 VAL   A C   1 
ATOM   673  O  O   . VAL   A 1 107 ? 11.154  -9.624  15.583  1.00 47.67  ? 168 VAL   A O   1 
ATOM   674  C  CB  . VAL   A 1 107 ? 9.200   -12.285 14.877  1.00 47.42  ? 168 VAL   A CB  1 
ATOM   675  C  CG1 . VAL   A 1 107 ? 10.521  -12.460 14.155  1.00 39.60  ? 168 VAL   A CG1 1 
ATOM   676  C  CG2 . VAL   A 1 107 ? 8.905   -13.497 15.760  1.00 38.74  ? 168 VAL   A CG2 1 
ATOM   677  N  N   . ILE   A 1 108 ? 9.546   -9.231  14.060  1.00 36.92  ? 169 ILE   A N   1 
ATOM   678  C  CA  . ILE   A 1 108 ? 10.293  -8.157  13.404  1.00 38.83  ? 169 ILE   A CA  1 
ATOM   679  C  C   . ILE   A 1 108 ? 10.539  -7.001  14.367  1.00 42.16  ? 169 ILE   A C   1 
ATOM   680  O  O   . ILE   A 1 108 ? 11.660  -6.491  14.472  1.00 41.17  ? 169 ILE   A O   1 
ATOM   681  C  CB  . ILE   A 1 108 ? 9.549   -7.680  12.142  1.00 40.20  ? 169 ILE   A CB  1 
ATOM   682  C  CG1 . ILE   A 1 108 ? 9.651   -8.717  11.033  1.00 37.50  ? 169 ILE   A CG1 1 
ATOM   683  C  CG2 . ILE   A 1 108 ? 10.102  -6.350  11.651  1.00 33.23  ? 169 ILE   A CG2 1 
ATOM   684  C  CD1 . ILE   A 1 108 ? 8.848   -8.335  9.821   1.00 42.95  ? 169 ILE   A CD1 1 
ATOM   685  N  N   . THR   A 1 109 ? 9.494   -6.557  15.074  1.00 41.31  ? 170 THR   A N   1 
ATOM   686  C  CA  . THR   A 1 109 ? 9.664   -5.416  15.970  1.00 47.96  ? 170 THR   A CA  1 
ATOM   687  C  C   . THR   A 1 109 ? 10.635  -5.734  17.097  1.00 43.59  ? 170 THR   A C   1 
ATOM   688  O  O   . THR   A 1 109 ? 11.446  -4.880  17.475  1.00 44.30  ? 170 THR   A O   1 
ATOM   689  C  CB  . THR   A 1 109 ? 8.317   -4.963  16.543  1.00 49.07  ? 170 THR   A CB  1 
ATOM   690  O  OG1 . THR   A 1 109 ? 7.647   -6.072  17.154  1.00 51.34  ? 170 THR   A OG1 1 
ATOM   691  C  CG2 . THR   A 1 109 ? 7.433   -4.386  15.439  1.00 42.92  ? 170 THR   A CG2 1 
ATOM   692  N  N   . SER   A 1 110 ? 10.582  -6.957  17.627  1.00 43.84  ? 171 SER   A N   1 
ATOM   693  C  CA  . SER   A 1 110 ? 11.492  -7.336  18.701  1.00 52.28  ? 171 SER   A CA  1 
ATOM   694  C  C   . SER   A 1 110 ? 12.937  -7.399  18.211  1.00 52.17  ? 171 SER   A C   1 
ATOM   695  O  O   . SER   A 1 110 ? 13.849  -6.902  18.884  1.00 42.35  ? 171 SER   A O   1 
ATOM   696  C  CB  . SER   A 1 110 ? 11.056  -8.676  19.297  1.00 38.34  ? 171 SER   A CB  1 
ATOM   697  O  OG  . SER   A 1 110 ? 11.790  -8.964  20.471  1.00 61.89  ? 171 SER   A OG  1 
ATOM   698  N  N   . SER   A 1 111 ? 13.164  -8.005  17.041  1.00 44.02  ? 172 SER   A N   1 
ATOM   699  C  CA  . SER   A 1 111 ? 14.517  -8.111  16.502  1.00 50.47  ? 172 SER   A CA  1 
ATOM   700  C  C   . SER   A 1 111 ? 15.102  -6.748  16.167  1.00 54.79  ? 172 SER   A C   1 
ATOM   701  O  O   . SER   A 1 111 ? 16.308  -6.533  16.339  1.00 60.57  ? 172 SER   A O   1 
ATOM   702  C  CB  . SER   A 1 111 ? 14.529  -9.003  15.261  1.00 37.11  ? 172 SER   A CB  1 
ATOM   703  O  OG  . SER   A 1 111 ? 14.155  -10.330 15.581  1.00 47.73  ? 172 SER   A OG  1 
ATOM   704  N  N   . LEU   A 1 112 ? 14.277  -5.829  15.668  1.00 50.16  ? 173 LEU   A N   1 
ATOM   705  C  CA  . LEU   A 1 112 ? 14.736  -4.462  15.470  1.00 50.04  ? 173 LEU   A CA  1 
ATOM   706  C  C   . LEU   A 1 112 ? 15.067  -3.790  16.794  1.00 48.42  ? 173 LEU   A C   1 
ATOM   707  O  O   . LEU   A 1 112 ? 16.005  -2.990  16.863  1.00 57.51  ? 173 LEU   A O   1 
ATOM   708  C  CB  . LEU   A 1 112 ? 13.676  -3.659  14.718  1.00 52.00  ? 173 LEU   A CB  1 
ATOM   709  C  CG  . LEU   A 1 112 ? 13.538  -3.982  13.231  1.00 43.45  ? 173 LEU   A CG  1 
ATOM   710  C  CD1 . LEU   A 1 112 ? 12.492  -3.086  12.609  1.00 51.52  ? 173 LEU   A CD1 1 
ATOM   711  C  CD2 . LEU   A 1 112 ? 14.868  -3.854  12.502  1.00 51.58  ? 173 LEU   A CD2 1 
ATOM   712  N  N   . GLU   A 1 113 ? 14.317  -4.086  17.856  1.00 52.45  ? 174 GLU   A N   1 
ATOM   713  C  CA  . GLU   A 1 113 ? 14.660  -3.490  19.142  1.00 57.06  ? 174 GLU   A CA  1 
ATOM   714  C  C   . GLU   A 1 113 ? 15.971  -4.064  19.673  1.00 58.57  ? 174 GLU   A C   1 
ATOM   715  O  O   . GLU   A 1 113 ? 16.784  -3.335  20.251  1.00 64.94  ? 174 GLU   A O   1 
ATOM   716  C  CB  . GLU   A 1 113 ? 13.514  -3.680  20.137  1.00 41.81  ? 174 GLU   A CB  1 
ATOM   717  N  N   . ASP   A 1 114 ? 16.212  -5.359  19.449  1.00 57.31  ? 175 ASP   A N   1 
ATOM   718  C  CA  . ASP   A 1 114 ? 17.472  -5.969  19.865  1.00 67.35  ? 175 ASP   A CA  1 
ATOM   719  C  C   . ASP   A 1 114 ? 18.661  -5.411  19.097  1.00 66.54  ? 175 ASP   A C   1 
ATOM   720  O  O   . ASP   A 1 114 ? 19.759  -5.293  19.655  1.00 68.77  ? 175 ASP   A O   1 
ATOM   721  C  CB  . ASP   A 1 114 ? 17.413  -7.482  19.685  1.00 63.63  ? 175 ASP   A CB  1 
ATOM   722  C  CG  . ASP   A 1 114 ? 17.173  -8.207  20.990  1.00 87.34  ? 175 ASP   A CG  1 
ATOM   723  O  OD1 . ASP   A 1 114 ? 17.541  -7.649  22.052  1.00 90.94  ? 175 ASP   A OD1 1 
ATOM   724  O  OD2 . ASP   A 1 114 ? 16.625  -9.331  20.953  1.00 79.54  ? 175 ASP   A OD2 1 
ATOM   725  N  N   . GLU   A 1 115 ? 18.473  -5.095  17.815  1.00 64.74  ? 176 GLU   A N   1 
ATOM   726  C  CA  . GLU   A 1 115 ? 19.519  -4.424  17.051  1.00 59.58  ? 176 GLU   A CA  1 
ATOM   727  C  C   . GLU   A 1 115 ? 19.763  -3.011  17.567  1.00 63.91  ? 176 GLU   A C   1 
ATOM   728  O  O   . GLU   A 1 115 ? 20.908  -2.546  17.578  1.00 76.64  ? 176 GLU   A O   1 
ATOM   729  C  CB  . GLU   A 1 115 ? 19.139  -4.396  15.570  1.00 51.55  ? 176 GLU   A CB  1 
ATOM   730  C  CG  . GLU   A 1 115 ? 20.310  -4.322  14.608  1.00 64.07  ? 176 GLU   A CG  1 
ATOM   731  C  CD  . GLU   A 1 115 ? 19.873  -4.389  13.147  1.00 63.01  ? 176 GLU   A CD  1 
ATOM   732  O  OE1 . GLU   A 1 115 ? 18.826  -5.017  12.864  1.00 60.98  ? 176 GLU   A OE1 1 
ATOM   733  O  OE2 . GLU   A 1 115 ? 20.576  -3.814  12.282  1.00 52.78  ? 176 GLU   A OE2 1 
ATOM   734  N  N   . ARG   A 1 116 ? 18.709  -2.320  18.005  1.00 59.79  ? 177 ARG   A N   1 
ATOM   735  C  CA  . ARG   A 1 116 ? 18.864  -0.976  18.548  1.00 71.87  ? 177 ARG   A CA  1 
ATOM   736  C  C   . ARG   A 1 116 ? 19.415  -0.988  19.969  1.00 73.15  ? 177 ARG   A C   1 
ATOM   737  O  O   . ARG   A 1 116 ? 20.003  0.009   20.408  1.00 73.29  ? 177 ARG   A O   1 
ATOM   738  C  CB  . ARG   A 1 116 ? 17.518  -0.233  18.503  1.00 68.48  ? 177 ARG   A CB  1 
ATOM   739  C  CG  . ARG   A 1 116 ? 17.567  1.227   18.993  1.00 66.23  ? 177 ARG   A CG  1 
ATOM   740  C  CD  . ARG   A 1 116 ? 16.184  1.781   19.348  1.00 62.59  ? 177 ARG   A CD  1 
ATOM   741  N  NE  . ARG   A 1 116 ? 15.265  0.818   19.969  1.00 65.74  ? 177 ARG   A NE  1 
ATOM   742  C  CZ  . ARG   A 1 116 ? 15.504  0.084   21.058  1.00 66.77  ? 177 ARG   A CZ  1 
ATOM   743  N  NH1 . ARG   A 1 116 ? 16.655  0.168   21.713  1.00 75.99  ? 177 ARG   A NH1 1 
ATOM   744  N  NH2 . ARG   A 1 116 ? 14.577  -0.757  21.491  1.00 66.88  ? 177 ARG   A NH2 1 
ATOM   745  N  N   . ASP   A 1 117 ? 19.243  -2.086  20.694  1.00 69.33  ? 178 ASP   A N   1 
ATOM   746  C  CA  . ASP   A 1 117 ? 19.821  -2.204  22.021  1.00 70.96  ? 178 ASP   A CA  1 
ATOM   747  C  C   . ASP   A 1 117 ? 21.324  -2.438  21.913  1.00 72.42  ? 178 ASP   A C   1 
ATOM   748  O  O   . ASP   A 1 117 ? 22.101  -1.905  22.705  1.00 72.81  ? 178 ASP   A O   1 
ATOM   749  C  CB  . ASP   A 1 117 ? 19.152  -3.336  22.802  1.00 72.24  ? 178 ASP   A CB  1 
ATOM   750  C  CG  . ASP   A 1 117 ? 17.739  -2.986  23.233  1.00 80.63  ? 178 ASP   A CG  1 
ATOM   751  O  OD1 . ASP   A 1 117 ? 17.456  -1.779  23.385  1.00 87.79  ? 178 ASP   A OD1 1 
ATOM   752  O  OD2 . ASP   A 1 117 ? 16.912  -3.907  23.417  1.00 84.31  ? 178 ASP   A OD2 1 
ATOM   753  N  N   . LYS   A 1 124 ? 18.948  4.037   20.512  1.00 55.71  ? 219 LYS   A N   1 
ATOM   754  C  CA  . LYS   A 1 124 ? 18.332  5.099   19.716  1.00 65.54  ? 219 LYS   A CA  1 
ATOM   755  C  C   . LYS   A 1 124 ? 16.826  5.278   19.984  1.00 64.46  ? 219 LYS   A C   1 
ATOM   756  O  O   . LYS   A 1 124 ? 16.314  4.899   21.039  1.00 57.37  ? 219 LYS   A O   1 
ATOM   757  C  CB  . LYS   A 1 124 ? 18.560  4.831   18.226  1.00 66.27  ? 219 LYS   A CB  1 
ATOM   758  N  N   . SER   A 1 125 ? 16.120  5.857   19.017  1.00 63.75  ? 220 SER   A N   1 
ATOM   759  C  CA  . SER   A 1 125 ? 14.709  6.181   19.190  1.00 53.40  ? 220 SER   A CA  1 
ATOM   760  C  C   . SER   A 1 125 ? 13.839  4.938   19.024  1.00 47.25  ? 220 SER   A C   1 
ATOM   761  O  O   . SER   A 1 125 ? 14.208  3.984   18.334  1.00 42.32  ? 220 SER   A O   1 
ATOM   762  C  CB  . SER   A 1 125 ? 14.284  7.258   18.187  1.00 59.32  ? 220 SER   A CB  1 
ATOM   763  O  OG  . SER   A 1 125 ? 12.958  7.700   18.426  1.00 68.92  ? 220 SER   A OG  1 
ATOM   764  N  N   . GLN   A 1 126 ? 12.671  4.957   19.669  1.00 45.42  ? 221 GLN   A N   1 
ATOM   765  C  CA  . GLN   A 1 126 ? 11.731  3.847   19.590  1.00 36.08  ? 221 GLN   A CA  1 
ATOM   766  C  C   . GLN   A 1 126 ? 10.990  3.855   18.258  1.00 37.88  ? 221 GLN   A C   1 
ATOM   767  O  O   . GLN   A 1 126 ? 10.727  4.912   17.677  1.00 38.09  ? 221 GLN   A O   1 
ATOM   768  C  CB  . GLN   A 1 126 ? 10.726  3.918   20.735  1.00 38.51  ? 221 GLN   A CB  1 
ATOM   769  C  CG  . GLN   A 1 126 ? 11.352  3.900   22.104  1.00 48.82  ? 221 GLN   A CG  1 
ATOM   770  C  CD  . GLN   A 1 126 ? 11.382  2.503   22.704  1.00 57.81  ? 221 GLN   A CD  1 
ATOM   771  O  OE1 . GLN   A 1 126 ? 11.412  1.502   21.981  1.00 54.17  ? 221 GLN   A OE1 1 
ATOM   772  N  NE2 . GLN   A 1 126 ? 11.372  2.429   24.035  1.00 59.47  ? 221 GLN   A NE2 1 
ATOM   773  N  N   . HIS   A 1 127 ? 10.662  2.659   17.765  1.00 32.16  ? 222 HIS   A N   1 
ATOM   774  C  CA  . HIS   A 1 127 ? 9.949   2.577   16.501  1.00 31.31  ? 222 HIS   A CA  1 
ATOM   775  C  C   . HIS   A 1 127 ? 8.532   3.126   16.667  1.00 34.88  ? 222 HIS   A C   1 
ATOM   776  O  O   . HIS   A 1 127 ? 7.941   3.034   17.747  1.00 31.85  ? 222 HIS   A O   1 
ATOM   777  C  CB  . HIS   A 1 127 ? 9.910   1.138   15.967  1.00 31.87  ? 222 HIS   A CB  1 
ATOM   778  C  CG  . HIS   A 1 127 ? 9.289   0.141   16.902  1.00 34.30  ? 222 HIS   A CG  1 
ATOM   779  N  ND1 . HIS   A 1 127 ? 7.924   -0.043  17.005  1.00 28.71  ? 222 HIS   A ND1 1 
ATOM   780  C  CD2 . HIS   A 1 127 ? 9.851   -0.739  17.763  1.00 31.37  ? 222 HIS   A CD2 1 
ATOM   781  C  CE1 . HIS   A 1 127 ? 7.675   -0.988  17.893  1.00 33.18  ? 222 HIS   A CE1 1 
ATOM   782  N  NE2 . HIS   A 1 127 ? 8.827   -1.429  18.366  1.00 44.33  ? 222 HIS   A NE2 1 
ATOM   783  N  N   . PRO   A 1 128 ? 7.962   3.703   15.607  1.00 34.90  ? 223 PRO   A N   1 
ATOM   784  C  CA  . PRO   A 1 128 ? 6.639   4.330   15.741  1.00 31.42  ? 223 PRO   A CA  1 
ATOM   785  C  C   . PRO   A 1 128 ? 5.526   3.380   16.171  1.00 33.31  ? 223 PRO   A C   1 
ATOM   786  O  O   . PRO   A 1 128 ? 4.435   3.865   16.489  1.00 31.48  ? 223 PRO   A O   1 
ATOM   787  C  CB  . PRO   A 1 128 ? 6.377   4.900   14.340  1.00 34.42  ? 223 PRO   A CB  1 
ATOM   788  C  CG  . PRO   A 1 128 ? 7.279   4.129   13.435  1.00 31.67  ? 223 PRO   A CG  1 
ATOM   789  C  CD  . PRO   A 1 128 ? 8.501   3.840   14.244  1.00 29.81  ? 223 PRO   A CD  1 
ATOM   790  N  N   . PHE   A 1 129 ? 5.740   2.064   16.208  1.00 30.94  ? 224 PHE   A N   1 
ATOM   791  C  CA  . PHE   A 1 129 ? 4.675   1.205   16.717  1.00 35.63  ? 224 PHE   A CA  1 
ATOM   792  C  C   . PHE   A 1 129 ? 4.689   1.089   18.237  1.00 36.09  ? 224 PHE   A C   1 
ATOM   793  O  O   . PHE   A 1 129 ? 3.707   0.609   18.812  1.00 35.41  ? 224 PHE   A O   1 
ATOM   794  C  CB  . PHE   A 1 129 ? 4.745   -0.197  16.091  1.00 32.92  ? 224 PHE   A CB  1 
ATOM   795  C  CG  . PHE   A 1 129 ? 4.298   -0.242  14.659  1.00 32.73  ? 224 PHE   A CG  1 
ATOM   796  C  CD1 . PHE   A 1 129 ? 2.949   -0.272  14.337  1.00 37.81  ? 224 PHE   A CD1 1 
ATOM   797  C  CD2 . PHE   A 1 129 ? 5.227   -0.252  13.630  1.00 28.05  ? 224 PHE   A CD2 1 
ATOM   798  C  CE1 . PHE   A 1 129 ? 2.531   -0.307  13.006  1.00 33.11  ? 224 PHE   A CE1 1 
ATOM   799  C  CE2 . PHE   A 1 129 ? 4.822   -0.288  12.306  1.00 26.06  ? 224 PHE   A CE2 1 
ATOM   800  C  CZ  . PHE   A 1 129 ? 3.474   -0.319  11.991  1.00 30.26  ? 224 PHE   A CZ  1 
ATOM   801  N  N   . HIS   A 1 130 ? 5.749   1.557   18.896  1.00 33.18  ? 225 HIS   A N   1 
ATOM   802  C  CA  . HIS   A 1 130 ? 5.913   1.373   20.332  1.00 34.71  ? 225 HIS   A CA  1 
ATOM   803  C  C   . HIS   A 1 130 ? 4.960   2.269   21.110  1.00 30.73  ? 225 HIS   A C   1 
ATOM   804  O  O   . HIS   A 1 130 ? 4.964   3.491   20.938  1.00 35.34  ? 225 HIS   A O   1 
ATOM   805  C  CB  . HIS   A 1 130 ? 7.360   1.664   20.729  1.00 36.94  ? 225 HIS   A CB  1 
ATOM   806  C  CG  . HIS   A 1 130 ? 7.691   1.288   22.137  1.00 43.21  ? 225 HIS   A CG  1 
ATOM   807  N  ND1 . HIS   A 1 130 ? 7.749   2.214   23.158  1.00 46.72  ? 225 HIS   A ND1 1 
ATOM   808  C  CD2 . HIS   A 1 130 ? 7.978   0.088   22.697  1.00 42.00  ? 225 HIS   A CD2 1 
ATOM   809  C  CE1 . HIS   A 1 130 ? 8.060   1.600   24.286  1.00 48.85  ? 225 HIS   A CE1 1 
ATOM   810  N  NE2 . HIS   A 1 130 ? 8.208   0.311   24.034  1.00 48.91  ? 225 HIS   A NE2 1 
ATOM   811  N  N   . GLY   A 1 131 ? 4.136   1.653   21.965  1.00 27.71  ? 226 GLY   A N   1 
ATOM   812  C  CA  . GLY   A 1 131 ? 3.266   2.402   22.844  1.00 31.65  ? 226 GLY   A CA  1 
ATOM   813  C  C   . GLY   A 1 131 ? 3.471   2.008   24.295  1.00 39.01  ? 226 GLY   A C   1 
ATOM   814  O  O   . GLY   A 1 131 ? 4.137   1.014   24.611  1.00 36.94  ? 226 GLY   A O   1 
ATOM   815  N  N   . ARG   A 1 132 ? 2.889   2.822   25.175  1.00 37.17  ? 227 ARG   A N   1 
ATOM   816  C  CA  . ARG   A 1 132 ? 2.872   2.602   26.614  1.00 40.83  ? 227 ARG   A CA  1 
ATOM   817  C  C   . ARG   A 1 132 ? 1.464   2.263   27.083  1.00 42.65  ? 227 ARG   A C   1 
ATOM   818  O  O   . ARG   A 1 132 ? 0.469   2.736   26.523  1.00 42.29  ? 227 ARG   A O   1 
ATOM   819  C  CB  . ARG   A 1 132 ? 3.341   3.837   27.384  1.00 39.11  ? 227 ARG   A CB  1 
ATOM   820  C  CG  . ARG   A 1 132 ? 4.823   4.070   27.373  1.00 41.52  ? 227 ARG   A CG  1 
ATOM   821  C  CD  . ARG   A 1 132 ? 5.208   5.012   28.494  1.00 32.41  ? 227 ARG   A CD  1 
ATOM   822  N  NE  . ARG   A 1 132 ? 4.621   6.346   28.357  1.00 37.05  ? 227 ARG   A NE  1 
ATOM   823  C  CZ  . ARG   A 1 132 ? 5.121   7.306   27.582  1.00 38.56  ? 227 ARG   A CZ  1 
ATOM   824  N  NH1 . ARG   A 1 132 ? 6.205   7.066   26.853  1.00 33.72  ? 227 ARG   A NH1 1 
ATOM   825  N  NH2 . ARG   A 1 132 ? 4.538   8.502   27.530  1.00 37.26  ? 227 ARG   A NH2 1 
ATOM   826  N  N   . LEU   A 1 133 ? 1.398   1.491   28.166  1.00 46.84  ? 228 LEU   A N   1 
ATOM   827  C  CA  . LEU   A 1 133 ? 0.143   0.952   28.659  1.00 43.35  ? 228 LEU   A CA  1 
ATOM   828  C  C   . LEU   A 1 133 ? 0.177   0.873   30.177  1.00 41.79  ? 228 LEU   A C   1 
ATOM   829  O  O   . LEU   A 1 133 ? 1.177   0.448   30.762  1.00 51.83  ? 228 LEU   A O   1 
ATOM   830  C  CB  . LEU   A 1 133 ? -0.107  -0.435  28.070  1.00 43.78  ? 228 LEU   A CB  1 
ATOM   831  C  CG  . LEU   A 1 133 ? -1.514  -0.991  28.181  1.00 41.72  ? 228 LEU   A CG  1 
ATOM   832  C  CD1 . LEU   A 1 133 ? -1.825  -1.683  26.877  1.00 42.97  ? 228 LEU   A CD1 1 
ATOM   833  C  CD2 . LEU   A 1 133 ? -1.601  -1.943  29.351  1.00 47.16  ? 228 LEU   A CD2 1 
ATOM   834  N  N   . THR   A 1 134 ? -0.927  1.277   30.801  1.00 39.25  ? 229 THR   A N   1 
ATOM   835  C  CA  . THR   A 1 134 ? -1.127  1.174   32.242  1.00 38.57  ? 229 THR   A CA  1 
ATOM   836  C  C   . THR   A 1 134 ? -2.330  0.280   32.482  1.00 36.60  ? 229 THR   A C   1 
ATOM   837  O  O   . THR   A 1 134 ? -3.390  0.484   31.878  1.00 46.24  ? 229 THR   A O   1 
ATOM   838  C  CB  . THR   A 1 134 ? -1.326  2.554   32.876  1.00 38.51  ? 229 THR   A CB  1 
ATOM   839  O  OG1 . THR   A 1 134 ? -0.099  3.295   32.808  1.00 49.93  ? 229 THR   A OG1 1 
ATOM   840  C  CG2 . THR   A 1 134 ? -1.743  2.426   34.315  1.00 33.73  ? 229 THR   A CG2 1 
ATOM   841  N  N   . SER   A 1 135 ? -2.161  -0.721  33.338  1.00 34.11  ? 230 SER   A N   1 
ATOM   842  C  CA  . SER   A 1 135 ? -3.159  -1.767  33.484  1.00 43.46  ? 230 SER   A CA  1 
ATOM   843  C  C   . SER   A 1 135 ? -3.478  -1.989  34.949  1.00 47.44  ? 230 SER   A C   1 
ATOM   844  O  O   . SER   A 1 135 ? -2.630  -1.789  35.820  1.00 54.01  ? 230 SER   A O   1 
ATOM   845  C  CB  . SER   A 1 135 ? -2.685  -3.082  32.872  1.00 41.23  ? 230 SER   A CB  1 
ATOM   846  O  OG  . SER   A 1 135 ? -2.183  -3.990  33.856  1.00 59.33  ? 230 SER   A OG  1 
ATOM   847  N  N   . ASN   A 1 136 ? -4.709  -2.423  35.205  1.00 57.65  ? 231 ASN   A N   1 
ATOM   848  C  CA  . ASN   A 1 136 ? -5.194  -2.633  36.560  1.00 51.69  ? 231 ASN   A CA  1 
ATOM   849  C  C   . ASN   A 1 136 ? -6.271  -3.699  36.494  1.00 57.16  ? 231 ASN   A C   1 
ATOM   850  O  O   . ASN   A 1 136 ? -7.034  -3.754  35.528  1.00 56.42  ? 231 ASN   A O   1 
ATOM   851  C  CB  . ASN   A 1 136 ? -5.740  -1.327  37.162  1.00 53.54  ? 231 ASN   A CB  1 
ATOM   852  C  CG  . ASN   A 1 136 ? -5.913  -1.383  38.665  1.00 61.03  ? 231 ASN   A CG  1 
ATOM   853  O  OD1 . ASN   A 1 136 ? -6.339  -0.404  39.282  1.00 83.89  ? 231 ASN   A OD1 1 
ATOM   854  N  ND2 . ASN   A 1 136 ? -5.569  -2.508  39.266  1.00 74.13  ? 231 ASN   A ND2 1 
ATOM   855  N  N   . MET   A 1 137 ? -6.328  -4.546  37.512  1.00 69.24  ? 232 MET   A N   1 
ATOM   856  C  CA  . MET   A 1 137 ? -7.339  -5.589  37.582  1.00 62.10  ? 232 MET   A CA  1 
ATOM   857  C  C   . MET   A 1 137 ? -8.288  -5.330  38.742  1.00 53.09  ? 232 MET   A C   1 
ATOM   858  O  O   . MET   A 1 137 ? -7.850  -5.075  39.867  1.00 53.14  ? 232 MET   A O   1 
ATOM   859  C  CB  . MET   A 1 137 ? -6.699  -6.960  37.737  1.00 52.13  ? 232 MET   A CB  1 
ATOM   860  C  CG  . MET   A 1 137 ? -7.244  -7.974  36.766  1.00 66.69  ? 232 MET   A CG  1 
ATOM   861  S  SD  . MET   A 1 137 ? -6.030  -9.271  36.529  1.00 88.90  ? 232 MET   A SD  1 
ATOM   862  C  CE  . MET   A 1 137 ? -4.777  -8.369  35.619  1.00 57.18  ? 232 MET   A CE  1 
ATOM   863  N  N   . VAL   A 1 138 ? -9.589  -5.410  38.464  1.00 47.09  ? 233 VAL   A N   1 
ATOM   864  C  CA  . VAL   A 1 138 ? -10.629 -5.117  39.445  1.00 54.93  ? 233 VAL   A CA  1 
ATOM   865  C  C   . VAL   A 1 138 ? -11.547 -6.327  39.573  1.00 51.62  ? 233 VAL   A C   1 
ATOM   866  O  O   . VAL   A 1 138 ? -11.991 -6.883  38.562  1.00 51.42  ? 233 VAL   A O   1 
ATOM   867  C  CB  . VAL   A 1 138 ? -11.448 -3.866  39.062  1.00 49.86  ? 233 VAL   A CB  1 
ATOM   868  C  CG1 . VAL   A 1 138 ? -12.581 -3.655  40.053  1.00 43.52  ? 233 VAL   A CG1 1 
ATOM   869  C  CG2 . VAL   A 1 138 ? -10.564 -2.632  38.993  1.00 52.71  ? 233 VAL   A CG2 1 
ATOM   870  N  N   . CYS   A 1 139 ? -11.845 -6.718  40.812  1.00 52.15  ? 234 CYS   A N   1 
ATOM   871  C  CA  . CYS   A 1 139 ? -12.766 -7.820  41.071  1.00 48.98  ? 234 CYS   A CA  1 
ATOM   872  C  C   . CYS   A 1 139 ? -14.213 -7.404  40.821  1.00 38.23  ? 234 CYS   A C   1 
ATOM   873  O  O   . CYS   A 1 139 ? -14.652 -6.340  41.260  1.00 49.43  ? 234 CYS   A O   1 
ATOM   874  C  CB  . CYS   A 1 139 ? -12.603 -8.302  42.513  1.00 44.24  ? 234 CYS   A CB  1 
ATOM   875  S  SG  . CYS   A 1 139 ? -13.924 -9.382  43.103  1.00 49.42  ? 234 CYS   A SG  1 
ATOM   876  N  N   . LYS   A 1 140 ? -14.965 -8.255  40.122  1.00 44.86  ? 235 LYS   A N   1 
ATOM   877  C  CA  . LYS   A 1 140 ? -16.343 -7.923  39.776  1.00 42.72  ? 235 LYS   A CA  1 
ATOM   878  C  C   . LYS   A 1 140 ? -17.327 -8.168  40.915  1.00 37.09  ? 235 LYS   A C   1 
ATOM   879  O  O   . LYS   A 1 140 ? -18.516 -7.888  40.748  1.00 44.30  ? 235 LYS   A O   1 
ATOM   880  C  CB  . LYS   A 1 140 ? -16.785 -8.710  38.533  1.00 43.28  ? 235 LYS   A CB  1 
ATOM   881  N  N   . HIS   A 1 141 ? -16.877 -8.676  42.061  1.00 40.61  ? 236 HIS   A N   1 
ATOM   882  C  CA  . HIS   A 1 141 ? -17.769 -8.930  43.184  1.00 43.78  ? 236 HIS   A CA  1 
ATOM   883  C  C   . HIS   A 1 141 ? -17.519 -8.024  44.383  1.00 44.42  ? 236 HIS   A C   1 
ATOM   884  O  O   . HIS   A 1 141 ? -18.377 -7.953  45.272  1.00 35.27  ? 236 HIS   A O   1 
ATOM   885  C  CB  . HIS   A 1 141 ? -17.667 -10.399 43.618  1.00 39.30  ? 236 HIS   A CB  1 
ATOM   886  C  CG  . HIS   A 1 141 ? -18.295 -11.346 42.645  1.00 55.17  ? 236 HIS   A CG  1 
ATOM   887  N  ND1 . HIS   A 1 141 ? -18.164 -12.715 42.739  1.00 63.93  ? 236 HIS   A ND1 1 
ATOM   888  C  CD2 . HIS   A 1 141 ? -19.056 -11.114 41.550  1.00 55.48  ? 236 HIS   A CD2 1 
ATOM   889  C  CE1 . HIS   A 1 141 ? -18.820 -13.285 41.744  1.00 66.83  ? 236 HIS   A CE1 1 
ATOM   890  N  NE2 . HIS   A 1 141 ? -19.366 -12.336 41.005  1.00 66.42  ? 236 HIS   A NE2 1 
ATOM   891  N  N   . CYS   A 1 142 ? -16.384 -7.329  44.429  1.00 40.89  ? 237 CYS   A N   1 
ATOM   892  C  CA  . CYS   A 1 142 ? -16.120 -6.400  45.520  1.00 40.31  ? 237 CYS   A CA  1 
ATOM   893  C  C   . CYS   A 1 142 ? -15.351 -5.162  45.092  1.00 39.02  ? 237 CYS   A C   1 
ATOM   894  O  O   . CYS   A 1 142 ? -15.094 -4.304  45.941  1.00 41.76  ? 237 CYS   A O   1 
ATOM   895  C  CB  . CYS   A 1 142 ? -15.354 -7.111  46.639  1.00 40.52  ? 237 CYS   A CB  1 
ATOM   896  S  SG  . CYS   A 1 142 ? -13.626 -7.423  46.218  1.00 39.44  ? 237 CYS   A SG  1 
ATOM   897  N  N   . GLU   A 1 143 ? -14.957 -5.049  43.823  1.00 46.87  ? 238 GLU   A N   1 
ATOM   898  C  CA  . GLU   A 1 143 ? -14.272 -3.873  43.284  1.00 46.78  ? 238 GLU   A CA  1 
ATOM   899  C  C   . GLU   A 1 143 ? -12.917 -3.639  43.955  1.00 51.17  ? 238 GLU   A C   1 
ATOM   900  O  O   . GLU   A 1 143 ? -12.450 -2.503  44.080  1.00 54.15  ? 238 GLU   A O   1 
ATOM   901  C  CB  . GLU   A 1 143 ? -15.153 -2.624  43.379  1.00 46.46  ? 238 GLU   A CB  1 
ATOM   902  C  CG  . GLU   A 1 143 ? -14.948 -1.626  42.240  1.00 62.63  ? 238 GLU   A CG  1 
ATOM   903  C  CD  . GLU   A 1 143 ? -15.816 -1.918  41.021  1.00 66.92  ? 238 GLU   A CD  1 
ATOM   904  O  OE1 . GLU   A 1 143 ? -16.351 -3.048  40.913  1.00 59.07  ? 238 GLU   A OE1 1 
ATOM   905  O  OE2 . GLU   A 1 143 ? -15.969 -1.007  40.175  1.00 64.58  ? 238 GLU   A OE2 1 
ATOM   906  N  N   . HIS   A 1 144 ? -12.262 -4.715  44.379  1.00 48.19  ? 239 HIS   A N   1 
ATOM   907  C  CA  . HIS   A 1 144 ? -10.885 -4.618  44.839  1.00 42.64  ? 239 HIS   A CA  1 
ATOM   908  C  C   . HIS   A 1 144 ? -9.965  -4.475  43.633  1.00 44.00  ? 239 HIS   A C   1 
ATOM   909  O  O   . HIS   A 1 144 ? -10.052 -5.249  42.673  1.00 49.03  ? 239 HIS   A O   1 
ATOM   910  C  CB  . HIS   A 1 144 ? -10.520 -5.846  45.679  1.00 43.29  ? 239 HIS   A CB  1 
ATOM   911  C  CG  . HIS   A 1 144 ? -9.057  -5.985  45.968  1.00 54.33  ? 239 HIS   A CG  1 
ATOM   912  N  ND1 . HIS   A 1 144 ? -8.394  -5.197  46.886  1.00 55.19  ? 239 HIS   A ND1 1 
ATOM   913  C  CD2 . HIS   A 1 144 ? -8.130  -6.832  45.462  1.00 52.22  ? 239 HIS   A CD2 1 
ATOM   914  C  CE1 . HIS   A 1 144 ? -7.122  -5.551  46.931  1.00 42.45  ? 239 HIS   A CE1 1 
ATOM   915  N  NE2 . HIS   A 1 144 ? -6.935  -6.540  46.074  1.00 51.06  ? 239 HIS   A NE2 1 
ATOM   916  N  N   . GLN   A 1 145 ? -9.090  -3.478  43.677  1.00 55.00  ? 240 GLN   A N   1 
ATOM   917  C  CA  . GLN   A 1 145 ? -8.202  -3.180  42.562  1.00 56.79  ? 240 GLN   A CA  1 
ATOM   918  C  C   . GLN   A 1 145 ? -6.821  -3.771  42.809  1.00 48.40  ? 240 GLN   A C   1 
ATOM   919  O  O   . GLN   A 1 145 ? -6.258  -3.619  43.900  1.00 45.99  ? 240 GLN   A O   1 
ATOM   920  C  CB  . GLN   A 1 145 ? -8.117  -1.667  42.330  1.00 50.88  ? 240 GLN   A CB  1 
ATOM   921  C  CG  . GLN   A 1 145 ? -9.488  -0.992  42.287  1.00 63.98  ? 240 GLN   A CG  1 
ATOM   922  C  CD  . GLN   A 1 145 ? -9.612  0.061   41.203  1.00 76.16  ? 240 GLN   A CD  1 
ATOM   923  O  OE1 . GLN   A 1 145 ? -8.610  0.511   40.637  1.00 74.71  ? 240 GLN   A OE1 1 
ATOM   924  N  NE2 . GLN   A 1 145 ? -10.857 0.441   40.885  1.00 62.80  ? 240 GLN   A NE2 1 
ATOM   925  N  N   . SER   A 1 146 ? -6.287  -4.442  41.791  1.00 54.77  ? 241 SER   A N   1 
ATOM   926  C  CA  . SER   A 1 146 ? -4.965  -5.029  41.860  1.00 57.31  ? 241 SER   A CA  1 
ATOM   927  C  C   . SER   A 1 146 ? -3.912  -3.930  41.813  1.00 58.52  ? 241 SER   A C   1 
ATOM   928  O  O   . SER   A 1 146 ? -4.221  -2.769  41.536  1.00 59.93  ? 241 SER   A O   1 
ATOM   929  C  CB  . SER   A 1 146 ? -4.775  -6.014  40.709  1.00 50.73  ? 241 SER   A CB  1 
ATOM   930  N  N   . PRO   A 1 147 ? -2.655  -4.260  42.095  1.00 64.23  ? 242 PRO   A N   1 
ATOM   931  C  CA  . PRO   A 1 147 ? -1.595  -3.262  41.931  1.00 67.04  ? 242 PRO   A CA  1 
ATOM   932  C  C   . PRO   A 1 147 ? -1.462  -2.865  40.468  1.00 59.91  ? 242 PRO   A C   1 
ATOM   933  O  O   . PRO   A 1 147 ? -1.673  -3.675  39.563  1.00 59.52  ? 242 PRO   A O   1 
ATOM   934  C  CB  . PRO   A 1 147 ? -0.344  -3.984  42.448  1.00 60.86  ? 242 PRO   A CB  1 
ATOM   935  C  CG  . PRO   A 1 147 ? -0.673  -5.436  42.327  1.00 59.83  ? 242 PRO   A CG  1 
ATOM   936  C  CD  . PRO   A 1 147 ? -2.128  -5.506  42.672  1.00 65.88  ? 242 PRO   A CD  1 
ATOM   937  N  N   . VAL   A 1 148 ? -1.126  -1.600  40.241  1.00 60.71  ? 243 VAL   A N   1 
ATOM   938  C  CA  . VAL   A 1 148 ? -1.055  -1.067  38.884  1.00 61.11  ? 243 VAL   A CA  1 
ATOM   939  C  C   . VAL   A 1 148 ? 0.245   -1.526  38.232  1.00 51.68  ? 243 VAL   A C   1 
ATOM   940  O  O   . VAL   A 1 148 ? 1.318   -1.470  38.846  1.00 55.06  ? 243 VAL   A O   1 
ATOM   941  C  CB  . VAL   A 1 148 ? -1.183  0.468   38.895  1.00 53.55  ? 243 VAL   A CB  1 
ATOM   942  C  CG1 . VAL   A 1 148 ? -0.129  1.102   39.795  1.00 68.17  ? 243 VAL   A CG1 1 
ATOM   943  C  CG2 . VAL   A 1 148 ? -1.077  1.018   37.489  1.00 53.99  ? 243 VAL   A CG2 1 
ATOM   944  N  N   . ARG   A 1 149 ? 0.148   -2.008  36.995  1.00 44.30  ? 244 ARG   A N   1 
ATOM   945  C  CA  . ARG   A 1 149 ? 1.302   -2.484  36.246  1.00 56.14  ? 244 ARG   A CA  1 
ATOM   946  C  C   . ARG   A 1 149 ? 1.510   -1.623  35.005  1.00 48.87  ? 244 ARG   A C   1 
ATOM   947  O  O   . ARG   A 1 149 ? 0.556   -1.101  34.419  1.00 43.94  ? 244 ARG   A O   1 
ATOM   948  C  CB  . ARG   A 1 149 ? 1.141   -3.953  35.840  1.00 53.53  ? 244 ARG   A CB  1 
ATOM   949  C  CG  . ARG   A 1 149 ? 1.634   -4.960  36.880  1.00 61.35  ? 244 ARG   A CG  1 
ATOM   950  C  CD  . ARG   A 1 149 ? 2.155   -6.248  36.235  1.00 69.73  ? 244 ARG   A CD  1 
ATOM   951  N  NE  . ARG   A 1 149 ? 1.352   -6.636  35.079  1.00 82.95  ? 244 ARG   A NE  1 
ATOM   952  C  CZ  . ARG   A 1 149 ? 1.780   -6.601  33.820  1.00 70.97  ? 244 ARG   A CZ  1 
ATOM   953  N  NH1 . ARG   A 1 149 ? 3.015   -6.203  33.545  1.00 66.62  ? 244 ARG   A NH1 1 
ATOM   954  N  NH2 . ARG   A 1 149 ? 0.971   -6.967  32.834  1.00 62.54  ? 244 ARG   A NH2 1 
ATOM   955  N  N   . PHE   A 1 150 ? 2.773   -1.469  34.619  1.00 51.80  ? 245 PHE   A N   1 
ATOM   956  C  CA  . PHE   A 1 150 ? 3.162   -0.650  33.480  1.00 47.48  ? 245 PHE   A CA  1 
ATOM   957  C  C   . PHE   A 1 150 ? 3.703   -1.549  32.376  1.00 47.05  ? 245 PHE   A C   1 
ATOM   958  O  O   . PHE   A 1 150 ? 4.593   -2.373  32.617  1.00 40.23  ? 245 PHE   A O   1 
ATOM   959  C  CB  . PHE   A 1 150 ? 4.201   0.396   33.891  1.00 47.80  ? 245 PHE   A CB  1 
ATOM   960  C  CG  . PHE   A 1 150 ? 3.765   1.266   35.043  1.00 50.52  ? 245 PHE   A CG  1 
ATOM   961  C  CD1 . PHE   A 1 150 ? 3.009   2.406   34.820  1.00 45.68  ? 245 PHE   A CD1 1 
ATOM   962  C  CD2 . PHE   A 1 150 ? 4.121   0.950   36.346  1.00 55.75  ? 245 PHE   A CD2 1 
ATOM   963  C  CE1 . PHE   A 1 150 ? 2.605   3.211   35.875  1.00 51.51  ? 245 PHE   A CE1 1 
ATOM   964  C  CE2 . PHE   A 1 150 ? 3.723   1.752   37.406  1.00 57.89  ? 245 PHE   A CE2 1 
ATOM   965  C  CZ  . PHE   A 1 150 ? 2.964   2.884   37.169  1.00 55.24  ? 245 PHE   A CZ  1 
ATOM   966  N  N   . ASP   A 1 151 ? 3.157   -1.401  31.174  1.00 41.40  ? 246 ASP   A N   1 
ATOM   967  C  CA  . ASP   A 1 151 ? 3.498   -2.279  30.068  1.00 49.00  ? 246 ASP   A CA  1 
ATOM   968  C  C   . ASP   A 1 151 ? 3.784   -1.463  28.818  1.00 44.92  ? 246 ASP   A C   1 
ATOM   969  O  O   . ASP   A 1 151 ? 3.552   -0.252  28.758  1.00 36.04  ? 246 ASP   A O   1 
ATOM   970  C  CB  . ASP   A 1 151 ? 2.382   -3.292  29.783  1.00 48.66  ? 246 ASP   A CB  1 
ATOM   971  C  CG  . ASP   A 1 151 ? 1.897   -3.991  31.035  1.00 66.93  ? 246 ASP   A CG  1 
ATOM   972  O  OD1 . ASP   A 1 151 ? 1.097   -3.390  31.791  1.00 71.64  ? 246 ASP   A OD1 1 
ATOM   973  O  OD2 . ASP   A 1 151 ? 2.329   -5.139  31.269  1.00 76.48  ? 246 ASP   A OD2 1 
ATOM   974  N  N   . THR   A 1 152 ? 4.308   -2.155  27.817  1.00 43.68  ? 247 THR   A N   1 
ATOM   975  C  CA  . THR   A 1 152 ? 4.508   -1.593  26.496  1.00 43.63  ? 247 THR   A CA  1 
ATOM   976  C  C   . THR   A 1 152 ? 3.789   -2.476  25.493  1.00 47.47  ? 247 THR   A C   1 
ATOM   977  O  O   . THR   A 1 152 ? 3.643   -3.683  25.700  1.00 52.30  ? 247 THR   A O   1 
ATOM   978  C  CB  . THR   A 1 152 ? 5.993   -1.488  26.130  1.00 37.85  ? 247 THR   A CB  1 
ATOM   979  O  OG1 . THR   A 1 152 ? 6.654   -2.718  26.448  1.00 48.18  ? 247 THR   A OG1 1 
ATOM   980  C  CG2 . THR   A 1 152 ? 6.650   -0.354  26.900  1.00 49.23  ? 247 THR   A CG2 1 
ATOM   981  N  N   . PHE   A 1 153 ? 3.328   -1.867  24.411  1.00 37.73  ? 248 PHE   A N   1 
ATOM   982  C  CA  . PHE   A 1 153 ? 2.715   -2.632  23.342  1.00 39.97  ? 248 PHE   A CA  1 
ATOM   983  C  C   . PHE   A 1 153 ? 3.258   -2.153  22.009  1.00 38.60  ? 248 PHE   A C   1 
ATOM   984  O  O   . PHE   A 1 153 ? 3.602   -0.977  21.851  1.00 35.90  ? 248 PHE   A O   1 
ATOM   985  C  CB  . PHE   A 1 153 ? 1.190   -2.518  23.371  1.00 33.72  ? 248 PHE   A CB  1 
ATOM   986  C  CG  . PHE   A 1 153 ? 0.684   -1.148  23.035  1.00 43.14  ? 248 PHE   A CG  1 
ATOM   987  C  CD1 . PHE   A 1 153 ? 0.619   -0.161  24.009  1.00 33.73  ? 248 PHE   A CD1 1 
ATOM   988  C  CD2 . PHE   A 1 153 ? 0.272   -0.843  21.745  1.00 38.39  ? 248 PHE   A CD2 1 
ATOM   989  C  CE1 . PHE   A 1 153 ? 0.155   1.098   23.703  1.00 34.29  ? 248 PHE   A CE1 1 
ATOM   990  C  CE2 . PHE   A 1 153 ? -0.190  0.424   21.434  1.00 30.64  ? 248 PHE   A CE2 1 
ATOM   991  C  CZ  . PHE   A 1 153 ? -0.251  1.392   22.413  1.00 30.09  ? 248 PHE   A CZ  1 
ATOM   992  N  N   . ASP   A 1 154 ? 3.371   -3.086  21.069  1.00 36.23  ? 249 ASP   A N   1 
ATOM   993  C  CA  . ASP   A 1 154 ? 3.611   -2.763  19.675  1.00 38.79  ? 249 ASP   A CA  1 
ATOM   994  C  C   . ASP   A 1 154 ? 2.351   -2.911  18.839  1.00 44.63  ? 249 ASP   A C   1 
ATOM   995  O  O   . ASP   A 1 154 ? 2.305   -2.414  17.707  1.00 39.66  ? 249 ASP   A O   1 
ATOM   996  C  CB  . ASP   A 1 154 ? 4.724   -3.651  19.112  1.00 36.27  ? 249 ASP   A CB  1 
ATOM   997  C  CG  . ASP   A 1 154 ? 5.989   -3.589  19.947  1.00 56.10  ? 249 ASP   A CG  1 
ATOM   998  O  OD1 . ASP   A 1 154 ? 6.215   -2.549  20.604  1.00 60.50  ? 249 ASP   A OD1 1 
ATOM   999  O  OD2 . ASP   A 1 154 ? 6.760   -4.572  19.948  1.00 66.47  ? 249 ASP   A OD2 1 
ATOM   1000 N  N   . SER   A 1 155 ? 1.333   -3.575  19.380  1.00 40.38  ? 250 SER   A N   1 
ATOM   1001 C  CA  . SER   A 1 155 ? 0.041   -3.704  18.730  1.00 32.35  ? 250 SER   A CA  1 
ATOM   1002 C  C   . SER   A 1 155 ? -0.995  -3.946  19.814  1.00 34.54  ? 250 SER   A C   1 
ATOM   1003 O  O   . SER   A 1 155 ? -0.674  -4.458  20.891  1.00 34.59  ? 250 SER   A O   1 
ATOM   1004 C  CB  . SER   A 1 155 ? 0.021   -4.843  17.706  1.00 39.82  ? 250 SER   A CB  1 
ATOM   1005 O  OG  . SER   A 1 155 ? -0.158  -6.106  18.329  1.00 41.24  ? 250 SER   A OG  1 
ATOM   1006 N  N   . LEU   A 1 156 ? -2.231  -3.558  19.524  1.00 28.16  ? 251 LEU   A N   1 
ATOM   1007 C  CA  . LEU   A 1 156 ? -3.357  -3.756  20.431  1.00 28.36  ? 251 LEU   A CA  1 
ATOM   1008 C  C   . LEU   A 1 156 ? -4.151  -4.967  19.949  1.00 32.17  ? 251 LEU   A C   1 
ATOM   1009 O  O   . LEU   A 1 156 ? -4.957  -4.866  19.020  1.00 33.79  ? 251 LEU   A O   1 
ATOM   1010 C  CB  . LEU   A 1 156 ? -4.227  -2.508  20.476  1.00 30.24  ? 251 LEU   A CB  1 
ATOM   1011 C  CG  . LEU   A 1 156 ? -3.550  -1.268  21.054  1.00 41.24  ? 251 LEU   A CG  1 
ATOM   1012 C  CD1 . LEU   A 1 156 ? -4.403  -0.047  20.802  1.00 26.73  ? 251 LEU   A CD1 1 
ATOM   1013 C  CD2 . LEU   A 1 156 ? -3.282  -1.444  22.539  1.00 35.24  ? 251 LEU   A CD2 1 
ATOM   1014 N  N   . SER   A 1 157 ? -3.927  -6.113  20.583  1.00 32.41  ? 252 SER   A N   1 
ATOM   1015 C  CA  . SER   A 1 157 ? -4.666  -7.322  20.241  1.00 39.03  ? 252 SER   A CA  1 
ATOM   1016 C  C   . SER   A 1 157 ? -6.008  -7.316  20.972  1.00 45.52  ? 252 SER   A C   1 
ATOM   1017 O  O   . SER   A 1 157 ? -6.042  -7.332  22.207  1.00 44.31  ? 252 SER   A O   1 
ATOM   1018 C  CB  . SER   A 1 157 ? -3.843  -8.558  20.605  1.00 37.71  ? 252 SER   A CB  1 
ATOM   1019 O  OG  . SER   A 1 157 ? -4.273  -9.711  19.902  1.00 51.58  ? 252 SER   A OG  1 
ATOM   1020 N  N   . LEU   A 1 158 ? -7.107  -7.303  20.217  1.00 44.28  ? 253 LEU   A N   1 
ATOM   1021 C  CA  . LEU   A 1 158 ? -8.448  -7.183  20.776  1.00 38.81  ? 253 LEU   A CA  1 
ATOM   1022 C  C   . LEU   A 1 158 ? -9.222  -8.482  20.610  1.00 42.57  ? 253 LEU   A C   1 
ATOM   1023 O  O   . LEU   A 1 158 ? -9.099  -9.159  19.587  1.00 42.79  ? 253 LEU   A O   1 
ATOM   1024 C  CB  . LEU   A 1 158 ? -9.233  -6.055  20.099  1.00 42.41  ? 253 LEU   A CB  1 
ATOM   1025 C  CG  . LEU   A 1 158 ? -8.505  -4.766  19.724  1.00 34.74  ? 253 LEU   A CG  1 
ATOM   1026 C  CD1 . LEU   A 1 158 ? -9.466  -3.790  19.073  1.00 28.67  ? 253 LEU   A CD1 1 
ATOM   1027 C  CD2 . LEU   A 1 158 ? -7.855  -4.157  20.950  1.00 36.77  ? 253 LEU   A CD2 1 
ATOM   1028 N  N   . SER   A 1 159 ? -10.046 -8.806  21.604  1.00 48.66  ? 254 SER   A N   1 
ATOM   1029 C  CA  . SER   A 1 159 ? -10.981 -9.911  21.477  1.00 43.71  ? 254 SER   A CA  1 
ATOM   1030 C  C   . SER   A 1 159 ? -12.174 -9.492  20.640  1.00 45.95  ? 254 SER   A C   1 
ATOM   1031 O  O   . SER   A 1 159 ? -12.507 -8.310  20.530  1.00 52.06  ? 254 SER   A O   1 
ATOM   1032 C  CB  . SER   A 1 159 ? -11.491 -10.375 22.840  1.00 42.37  ? 254 SER   A CB  1 
ATOM   1033 O  OG  . SER   A 1 159 ? -10.451 -10.894 23.639  1.00 57.69  ? 254 SER   A OG  1 
ATOM   1034 N  N   . ILE   A 1 160 ? -12.857 -10.486 20.088  1.00 40.21  ? 255 ILE   A N   1 
ATOM   1035 C  CA  . ILE   A 1 160 ? -14.080 -10.235 19.343  1.00 45.78  ? 255 ILE   A CA  1 
ATOM   1036 C  C   . ILE   A 1 160 ? -15.251 -10.758 20.174  1.00 54.29  ? 255 ILE   A C   1 
ATOM   1037 O  O   . ILE   A 1 160 ? -15.357 -11.974 20.401  1.00 48.49  ? 255 ILE   A O   1 
ATOM   1038 C  CB  . ILE   A 1 160 ? -14.040 -10.883 17.955  1.00 47.25  ? 255 ILE   A CB  1 
ATOM   1039 C  CG1 . ILE   A 1 160 ? -12.667 -10.646 17.313  1.00 46.43  ? 255 ILE   A CG1 1 
ATOM   1040 C  CG2 . ILE   A 1 160 ? -15.164 -10.329 17.103  1.00 46.27  ? 255 ILE   A CG2 1 
ATOM   1041 C  CD1 . ILE   A 1 160 ? -12.374 -11.539 16.120  1.00 35.00  ? 255 ILE   A CD1 1 
ATOM   1042 N  N   . PRO   A 1 161 ? -16.146 -9.887  20.654  1.00 57.98  ? 256 PRO   A N   1 
ATOM   1043 C  CA  . PRO   A 1 161 ? -17.294 -10.358 21.445  1.00 58.36  ? 256 PRO   A CA  1 
ATOM   1044 C  C   . PRO   A 1 161 ? -18.266 -11.219 20.651  1.00 60.90  ? 256 PRO   A C   1 
ATOM   1045 O  O   . PRO   A 1 161 ? -18.110 -11.413 19.440  1.00 54.30  ? 256 PRO   A O   1 
ATOM   1046 C  CB  . PRO   A 1 161 ? -17.966 -9.057  21.906  1.00 48.27  ? 256 PRO   A CB  1 
ATOM   1047 C  CG  . PRO   A 1 161 ? -16.920 -8.000  21.754  1.00 52.62  ? 256 PRO   A CG  1 
ATOM   1048 C  CD  . PRO   A 1 161 ? -16.093 -8.419  20.578  1.00 51.50  ? 256 PRO   A CD  1 
ATOM   1049 N  N   . ALA   A 1 162 ? -19.288 -11.724 21.339  1.00 64.32  ? 257 ALA   A N   1 
ATOM   1050 C  CA  . ALA   A 1 162 ? -20.282 -12.587 20.715  1.00 57.06  ? 257 ALA   A CA  1 
ATOM   1051 C  C   . ALA   A 1 162 ? -21.188 -11.798 19.776  1.00 59.11  ? 257 ALA   A C   1 
ATOM   1052 O  O   . ALA   A 1 162 ? -21.569 -10.660 20.059  1.00 55.75  ? 257 ALA   A O   1 
ATOM   1053 C  CB  . ALA   A 1 162 ? -21.122 -13.279 21.788  1.00 57.52  ? 257 ALA   A CB  1 
ATOM   1054 N  N   . ALA   A 1 163 ? -21.539 -12.421 18.656  1.00 67.38  ? 258 ALA   A N   1 
ATOM   1055 C  CA  . ALA   A 1 163 ? -22.402 -11.816 17.654  1.00 74.31  ? 258 ALA   A CA  1 
ATOM   1056 C  C   . ALA   A 1 163 ? -23.875 -12.030 18.006  1.00 76.01  ? 258 ALA   A C   1 
ATOM   1057 O  O   . ALA   A 1 163 ? -24.227 -12.821 18.885  1.00 72.92  ? 258 ALA   A O   1 
ATOM   1058 C  CB  . ALA   A 1 163 ? -22.089 -12.391 16.271  1.00 78.69  ? 258 ALA   A CB  1 
ATOM   1059 N  N   . THR   A 1 164 ? -24.743 -11.306 17.302  1.00 87.52  ? 259 THR   A N   1 
ATOM   1060 C  CA  . THR   A 1 164 ? -26.184 -11.421 17.492  1.00 92.66  ? 259 THR   A CA  1 
ATOM   1061 C  C   . THR   A 1 164 ? -26.880 -11.006 16.204  1.00 95.51  ? 259 THR   A C   1 
ATOM   1062 O  O   . THR   A 1 164 ? -26.397 -10.131 15.478  1.00 92.81  ? 259 THR   A O   1 
ATOM   1063 C  CB  . THR   A 1 164 ? -26.674 -10.563 18.667  1.00 82.53  ? 259 THR   A CB  1 
ATOM   1064 N  N   . TRP   A 1 165 ? -28.014 -11.649 15.925  1.00 85.40  ? 260 TRP   A N   1 
ATOM   1065 C  CA  . TRP   A 1 165 ? -28.784 -11.323 14.729  1.00 86.67  ? 260 TRP   A CA  1 
ATOM   1066 C  C   . TRP   A 1 165 ? -29.354 -9.914  14.856  1.00 90.39  ? 260 TRP   A C   1 
ATOM   1067 O  O   . TRP   A 1 165 ? -30.074 -9.612  15.813  1.00 96.27  ? 260 TRP   A O   1 
ATOM   1068 C  CB  . TRP   A 1 165 ? -29.903 -12.343 14.517  1.00 73.50  ? 260 TRP   A CB  1 
ATOM   1069 N  N   . GLY   A 1 166 ? -29.034 -9.048  13.895  1.00 84.32  ? 261 GLY   A N   1 
ATOM   1070 C  CA  . GLY   A 1 166 ? -29.459 -7.665  13.952  1.00 76.46  ? 261 GLY   A CA  1 
ATOM   1071 C  C   . GLY   A 1 166 ? -28.590 -6.767  14.806  1.00 84.70  ? 261 GLY   A C   1 
ATOM   1072 O  O   . GLY   A 1 166 ? -28.876 -5.564  14.905  1.00 70.26  ? 261 GLY   A O   1 
ATOM   1073 N  N   . HIS   A 1 167 ? -27.549 -7.312  15.429  1.00 89.83  ? 262 HIS   A N   1 
ATOM   1074 C  CA  . HIS   A 1 167 ? -26.598 -6.541  16.229  1.00 89.30  ? 262 HIS   A CA  1 
ATOM   1075 C  C   . HIS   A 1 167 ? -25.229 -6.657  15.577  1.00 86.64  ? 262 HIS   A C   1 
ATOM   1076 O  O   . HIS   A 1 167 ? -24.560 -7.698  15.708  1.00 83.91  ? 262 HIS   A O   1 
ATOM   1077 C  CB  . HIS   A 1 167 ? -26.552 -7.038  17.673  1.00 89.83  ? 262 HIS   A CB  1 
ATOM   1078 C  CG  . HIS   A 1 167 ? -27.903 -7.273  18.271  1.00 92.82  ? 262 HIS   A CG  1 
ATOM   1079 N  ND1 . HIS   A 1 167 ? -28.767 -8.237  17.799  1.00 96.45  ? 262 HIS   A ND1 1 
ATOM   1080 C  CD2 . HIS   A 1 167 ? -28.546 -6.658  19.291  1.00 87.89  ? 262 HIS   A CD2 1 
ATOM   1081 C  CE1 . HIS   A 1 167 ? -29.881 -8.212  18.507  1.00 97.63  ? 262 HIS   A CE1 1 
ATOM   1082 N  NE2 . HIS   A 1 167 ? -29.773 -7.263  19.419  1.00 92.37  ? 262 HIS   A NE2 1 
ATOM   1083 N  N   . PRO   A 1 168 ? -24.770 -5.628  14.875  1.00 85.52  ? 263 PRO   A N   1 
ATOM   1084 C  CA  . PRO   A 1 168 ? -23.499 -5.727  14.153  1.00 70.33  ? 263 PRO   A CA  1 
ATOM   1085 C  C   . PRO   A 1 168 ? -22.303 -5.539  15.073  1.00 60.13  ? 263 PRO   A C   1 
ATOM   1086 O  O   . PRO   A 1 168 ? -22.336 -4.760  16.028  1.00 52.16  ? 263 PRO   A O   1 
ATOM   1087 C  CB  . PRO   A 1 168 ? -23.583 -4.585  13.132  1.00 73.47  ? 263 PRO   A CB  1 
ATOM   1088 C  CG  . PRO   A 1 168 ? -24.690 -3.657  13.636  1.00 83.67  ? 263 PRO   A CG  1 
ATOM   1089 C  CD  . PRO   A 1 168 ? -25.329 -4.266  14.849  1.00 86.25  ? 263 PRO   A CD  1 
ATOM   1090 N  N   . LEU   A 1 169 ? -21.233 -6.270  14.760  1.00 55.64  ? 264 LEU   A N   1 
ATOM   1091 C  CA  . LEU   A 1 169 ? -19.967 -6.163  15.480  1.00 49.12  ? 264 LEU   A CA  1 
ATOM   1092 C  C   . LEU   A 1 169 ? -19.152 -5.001  14.917  1.00 47.91  ? 264 LEU   A C   1 
ATOM   1093 O  O   . LEU   A 1 169 ? -18.855 -4.972  13.717  1.00 50.40  ? 264 LEU   A O   1 
ATOM   1094 C  CB  . LEU   A 1 169 ? -19.181 -7.466  15.367  1.00 46.44  ? 264 LEU   A CB  1 
ATOM   1095 C  CG  . LEU   A 1 169 ? -19.520 -8.517  16.424  1.00 59.86  ? 264 LEU   A CG  1 
ATOM   1096 C  CD1 . LEU   A 1 169 ? -19.239 -9.929  15.916  1.00 63.63  ? 264 LEU   A CD1 1 
ATOM   1097 C  CD2 . LEU   A 1 169 ? -18.762 -8.246  17.707  1.00 59.68  ? 264 LEU   A CD2 1 
ATOM   1098 N  N   . THR   A 1 170 ? -18.789 -4.050  15.775  1.00 37.41  ? 265 THR   A N   1 
ATOM   1099 C  CA  . THR   A 1 170 ? -17.998 -2.893  15.382  1.00 42.73  ? 265 THR   A CA  1 
ATOM   1100 C  C   . THR   A 1 170 ? -16.629 -2.925  16.053  1.00 42.53  ? 265 THR   A C   1 
ATOM   1101 O  O   . THR   A 1 170 ? -16.422 -3.605  17.061  1.00 45.06  ? 265 THR   A O   1 
ATOM   1102 C  CB  . THR   A 1 170 ? -18.712 -1.584  15.739  1.00 50.38  ? 265 THR   A CB  1 
ATOM   1103 O  OG1 . THR   A 1 170 ? -18.570 -1.324  17.142  1.00 55.85  ? 265 THR   A OG1 1 
ATOM   1104 C  CG2 . THR   A 1 170 ? -20.188 -1.667  15.391  1.00 54.76  ? 265 THR   A CG2 1 
ATOM   1105 N  N   . LEU   A 1 171 ? -15.685 -2.172  15.477  1.00 42.51  ? 266 LEU   A N   1 
ATOM   1106 C  CA  . LEU   A 1 171 ? -14.355 -2.080  16.076  1.00 41.62  ? 266 LEU   A CA  1 
ATOM   1107 C  C   . LEU   A 1 171 ? -14.390 -1.321  17.390  1.00 41.21  ? 266 LEU   A C   1 
ATOM   1108 O  O   . LEU   A 1 171 ? -13.599 -1.614  18.294  1.00 37.71  ? 266 LEU   A O   1 
ATOM   1109 C  CB  . LEU   A 1 171 ? -13.375 -1.405  15.116  1.00 41.05  ? 266 LEU   A CB  1 
ATOM   1110 C  CG  . LEU   A 1 171 ? -11.948 -1.150  15.613  1.00 35.97  ? 266 LEU   A CG  1 
ATOM   1111 C  CD1 . LEU   A 1 171 ? -11.201 -2.459  15.854  1.00 38.15  ? 266 LEU   A CD1 1 
ATOM   1112 C  CD2 . LEU   A 1 171 ? -11.197 -0.275  14.628  1.00 39.07  ? 266 LEU   A CD2 1 
ATOM   1113 N  N   . ASP   A 1 172 ? -15.286 -0.341  17.509  1.00 44.51  ? 267 ASP   A N   1 
ATOM   1114 C  CA  . ASP   A 1 172 ? -15.413 0.385   18.765  1.00 51.01  ? 267 ASP   A CA  1 
ATOM   1115 C  C   . ASP   A 1 172 ? -15.853 -0.540  19.886  1.00 48.55  ? 267 ASP   A C   1 
ATOM   1116 O  O   . ASP   A 1 172 ? -15.277 -0.516  20.979  1.00 54.36  ? 267 ASP   A O   1 
ATOM   1117 C  CB  . ASP   A 1 172 ? -16.388 1.546   18.608  1.00 56.54  ? 267 ASP   A CB  1 
ATOM   1118 C  CG  . ASP   A 1 172 ? -15.769 2.728   17.878  1.00 78.02  ? 267 ASP   A CG  1 
ATOM   1119 O  OD1 . ASP   A 1 172 ? -14.528 2.890   17.945  1.00 77.04  ? 267 ASP   A OD1 1 
ATOM   1120 O  OD2 . ASP   A 1 172 ? -16.524 3.494   17.237  1.00 82.94  ? 267 ASP   A OD2 1 
ATOM   1121 N  N   . HIS   A 1 173 ? -16.859 -1.379  19.625  1.00 48.25  ? 268 HIS   A N   1 
ATOM   1122 C  CA  . HIS   A 1 173 ? -17.282 -2.358  20.620  1.00 46.75  ? 268 HIS   A CA  1 
ATOM   1123 C  C   . HIS   A 1 173 ? -16.109 -3.215  21.075  1.00 44.44  ? 268 HIS   A C   1 
ATOM   1124 O  O   . HIS   A 1 173 ? -15.977 -3.517  22.267  1.00 53.26  ? 268 HIS   A O   1 
ATOM   1125 C  CB  . HIS   A 1 173 ? -18.402 -3.233  20.055  1.00 42.10  ? 268 HIS   A CB  1 
ATOM   1126 N  N   . CYS   A 1 174 ? -15.235 -3.601  20.142  1.00 41.62  ? 269 CYS   A N   1 
ATOM   1127 C  CA  . CYS   A 1 174 ? -14.067 -4.397  20.508  1.00 43.04  ? 269 CYS   A CA  1 
ATOM   1128 C  C   . CYS   A 1 174 ? -13.080 -3.586  21.332  1.00 39.50  ? 269 CYS   A C   1 
ATOM   1129 O  O   . CYS   A 1 174 ? -12.403 -4.136  22.207  1.00 41.05  ? 269 CYS   A O   1 
ATOM   1130 C  CB  . CYS   A 1 174 ? -13.382 -4.934  19.250  1.00 38.66  ? 269 CYS   A CB  1 
ATOM   1131 S  SG  . CYS   A 1 174 ? -14.376 -6.083  18.287  1.00 53.25  ? 269 CYS   A SG  1 
ATOM   1132 N  N   . LEU   A 1 175 ? -12.989 -2.285  21.055  1.00 48.21  ? 270 LEU   A N   1 
ATOM   1133 C  CA  . LEU   A 1 175 ? -12.066 -1.410  21.769  1.00 46.37  ? 270 LEU   A CA  1 
ATOM   1134 C  C   . LEU   A 1 175 ? -12.562 -1.109  23.176  1.00 46.81  ? 270 LEU   A C   1 
ATOM   1135 O  O   . LEU   A 1 175 ? -11.762 -1.028  24.114  1.00 46.26  ? 270 LEU   A O   1 
ATOM   1136 C  CB  . LEU   A 1 175 ? -11.869 -0.111  20.988  1.00 39.63  ? 270 LEU   A CB  1 
ATOM   1137 C  CG  . LEU   A 1 175 ? -10.889 -0.180  19.817  1.00 43.10  ? 270 LEU   A CG  1 
ATOM   1138 C  CD1 . LEU   A 1 175 ? -11.034 1.046   18.921  1.00 47.40  ? 270 LEU   A CD1 1 
ATOM   1139 C  CD2 . LEU   A 1 175 ? -9.459  -0.319  20.322  1.00 41.71  ? 270 LEU   A CD2 1 
ATOM   1140 N  N   . HIS   A 1 176 ? -13.876 -0.930  23.346  1.00 50.87  ? 271 HIS   A N   1 
ATOM   1141 C  CA  . HIS   A 1 176 ? -14.415 -0.754  24.693  1.00 50.67  ? 271 HIS   A CA  1 
ATOM   1142 C  C   . HIS   A 1 176 ? -14.271 -2.032  25.513  1.00 48.09  ? 271 HIS   A C   1 
ATOM   1143 O  O   . HIS   A 1 176 ? -13.922 -1.979  26.699  1.00 44.49  ? 271 HIS   A O   1 
ATOM   1144 C  CB  . HIS   A 1 176 ? -15.878 -0.320  24.631  1.00 52.21  ? 271 HIS   A CB  1 
ATOM   1145 C  CG  . HIS   A 1 176 ? -16.086 1.028   24.015  1.00 64.62  ? 271 HIS   A CG  1 
ATOM   1146 N  ND1 . HIS   A 1 176 ? -15.703 2.198   24.634  1.00 68.15  ? 271 HIS   A ND1 1 
ATOM   1147 C  CD2 . HIS   A 1 176 ? -16.646 1.391   22.835  1.00 72.00  ? 271 HIS   A CD2 1 
ATOM   1148 C  CE1 . HIS   A 1 176 ? -16.014 3.224   23.859  1.00 77.37  ? 271 HIS   A CE1 1 
ATOM   1149 N  NE2 . HIS   A 1 176 ? -16.586 2.761   22.761  1.00 73.75  ? 271 HIS   A NE2 1 
ATOM   1150 N  N   . HIS   A 1 177 ? -14.521 -3.191  24.898  1.00 40.96  ? 272 HIS   A N   1 
ATOM   1151 C  CA  . HIS   A 1 177 ? -14.331 -4.447  25.610  1.00 43.68  ? 272 HIS   A CA  1 
ATOM   1152 C  C   . HIS   A 1 177 ? -12.873 -4.652  25.985  1.00 47.48  ? 272 HIS   A C   1 
ATOM   1153 O  O   . HIS   A 1 177 ? -12.578 -5.181  27.062  1.00 47.52  ? 272 HIS   A O   1 
ATOM   1154 C  CB  . HIS   A 1 177 ? -14.834 -5.616  24.764  1.00 39.97  ? 272 HIS   A CB  1 
ATOM   1155 C  CG  . HIS   A 1 177 ? -14.662 -6.954  25.416  1.00 46.63  ? 272 HIS   A CG  1 
ATOM   1156 N  ND1 . HIS   A 1 177 ? -13.620 -7.802  25.107  1.00 54.00  ? 272 HIS   A ND1 1 
ATOM   1157 C  CD2 . HIS   A 1 177 ? -15.397 -7.589  26.361  1.00 40.58  ? 272 HIS   A CD2 1 
ATOM   1158 C  CE1 . HIS   A 1 177 ? -13.725 -8.907  25.824  1.00 50.42  ? 272 HIS   A CE1 1 
ATOM   1159 N  NE2 . HIS   A 1 177 ? -14.793 -8.801  26.596  1.00 48.91  ? 272 HIS   A NE2 1 
ATOM   1160 N  N   . PHE   A 1 178 ? -11.954 -4.228  25.118  1.00 51.05  ? 273 PHE   A N   1 
ATOM   1161 C  CA  . PHE   A 1 178 ? -10.534 -4.375  25.413  1.00 48.86  ? 273 PHE   A CA  1 
ATOM   1162 C  C   . PHE   A 1 178 ? -10.105 -3.477  26.567  1.00 42.42  ? 273 PHE   A C   1 
ATOM   1163 O  O   . PHE   A 1 178 ? -9.237  -3.862  27.357  1.00 52.85  ? 273 PHE   A O   1 
ATOM   1164 C  CB  . PHE   A 1 178 ? -9.722  -4.084  24.148  1.00 41.40  ? 273 PHE   A CB  1 
ATOM   1165 C  CG  . PHE   A 1 178 ? -8.277  -3.793  24.401  1.00 40.42  ? 273 PHE   A CG  1 
ATOM   1166 C  CD1 . PHE   A 1 178 ? -7.393  -4.817  24.689  1.00 42.91  ? 273 PHE   A CD1 1 
ATOM   1167 C  CD2 . PHE   A 1 178 ? -7.794  -2.498  24.316  1.00 43.53  ? 273 PHE   A CD2 1 
ATOM   1168 C  CE1 . PHE   A 1 178 ? -6.055  -4.557  24.904  1.00 40.08  ? 273 PHE   A CE1 1 
ATOM   1169 C  CE2 . PHE   A 1 178 ? -6.457  -2.227  24.536  1.00 45.54  ? 273 PHE   A CE2 1 
ATOM   1170 C  CZ  . PHE   A 1 178 ? -5.584  -3.258  24.827  1.00 44.00  ? 273 PHE   A CZ  1 
ATOM   1171 N  N   . ILE   A 1 179 ? -10.728 -2.310  26.705  1.00 38.74  ? 274 ILE   A N   1 
ATOM   1172 C  CA  . ILE   A 1 179 ? -10.299 -1.306  27.677  1.00 45.57  ? 274 ILE   A CA  1 
ATOM   1173 C  C   . ILE   A 1 179 ? -10.855 -1.584  29.064  1.00 49.48  ? 274 ILE   A C   1 
ATOM   1174 O  O   . ILE   A 1 179 ? -10.121 -1.553  30.054  1.00 54.50  ? 274 ILE   A O   1 
ATOM   1175 C  CB  . ILE   A 1 179 ? -10.701 0.105   27.204  1.00 42.91  ? 274 ILE   A CB  1 
ATOM   1176 C  CG1 . ILE   A 1 179 ? -9.823  0.538   26.037  1.00 46.94  ? 274 ILE   A CG1 1 
ATOM   1177 C  CG2 . ILE   A 1 179 ? -10.569 1.094   28.343  1.00 35.34  ? 274 ILE   A CG2 1 
ATOM   1178 C  CD1 . ILE   A 1 179 ? -8.366  0.586   26.380  1.00 46.10  ? 274 ILE   A CD1 1 
ATOM   1179 N  N   . SER   A 1 180 ? -12.161 -1.826  29.184  1.00 44.57  ? 275 SER   A N   1 
ATOM   1180 C  CA  . SER   A 1 180 ? -12.758 -1.953  30.509  1.00 54.50  ? 275 SER   A CA  1 
ATOM   1181 C  C   . SER   A 1 180 ? -13.667 -3.170  30.644  1.00 56.90  ? 275 SER   A C   1 
ATOM   1182 O  O   . SER   A 1 180 ? -14.441 -3.244  31.602  1.00 65.61  ? 275 SER   A O   1 
ATOM   1183 C  CB  . SER   A 1 180 ? -13.535 -0.686  30.869  1.00 55.47  ? 275 SER   A CB  1 
ATOM   1184 O  OG  . SER   A 1 180 ? -14.753 -0.632  30.150  1.00 46.82  ? 275 SER   A OG  1 
ATOM   1185 N  N   . SER   A 1 181 ? -13.604 -4.128  29.718  1.00 57.43  ? 276 SER   A N   1 
ATOM   1186 C  CA  . SER   A 1 181 ? -14.465 -5.298  29.846  1.00 51.49  ? 276 SER   A CA  1 
ATOM   1187 C  C   . SER   A 1 181 ? -13.737 -6.608  29.574  1.00 53.63  ? 276 SER   A C   1 
ATOM   1188 O  O   . SER   A 1 181 ? -14.394 -7.655  29.494  1.00 54.93  ? 276 SER   A O   1 
ATOM   1189 C  CB  . SER   A 1 181 ? -15.681 -5.181  28.921  1.00 52.97  ? 276 SER   A CB  1 
ATOM   1190 N  N   . GLU   A 1 182 ? -12.414 -6.591  29.433  1.00 61.65  ? 277 GLU   A N   1 
ATOM   1191 C  CA  . GLU   A 1 182 ? -11.660 -7.816  29.199  1.00 60.26  ? 277 GLU   A CA  1 
ATOM   1192 C  C   . GLU   A 1 182 ? -11.646 -8.655  30.473  1.00 63.23  ? 277 GLU   A C   1 
ATOM   1193 O  O   . GLU   A 1 182 ? -11.249 -8.170  31.540  1.00 59.61  ? 277 GLU   A O   1 
ATOM   1194 C  CB  . GLU   A 1 182 ? -10.242 -7.488  28.738  1.00 50.69  ? 277 GLU   A CB  1 
ATOM   1195 N  N   . SER   A 1 183 ? -12.085 -9.908  30.362  1.00 72.84  ? 278 SER   A N   1 
ATOM   1196 C  CA  . SER   A 1 183 ? -12.145 -10.818 31.498  1.00 71.77  ? 278 SER   A CA  1 
ATOM   1197 C  C   . SER   A 1 183 ? -10.892 -11.676 31.570  1.00 72.20  ? 278 SER   A C   1 
ATOM   1198 O  O   . SER   A 1 183 ? -10.385 -12.144 30.545  1.00 77.58  ? 278 SER   A O   1 
ATOM   1199 C  CB  . SER   A 1 183 ? -13.375 -11.720 31.391  1.00 71.91  ? 278 SER   A CB  1 
ATOM   1200 O  OG  . SER   A 1 183 ? -13.860 -12.111 32.663  1.00 76.98  ? 278 SER   A OG  1 
ATOM   1201 N  N   . VAL   A 1 184 ? -10.410 -11.894 32.791  1.00 71.58  ? 279 VAL   A N   1 
ATOM   1202 C  CA  . VAL   A 1 184 ? -9.241  -12.729 33.056  1.00 70.34  ? 279 VAL   A CA  1 
ATOM   1203 C  C   . VAL   A 1 184 ? -9.520  -13.541 34.315  1.00 71.13  ? 279 VAL   A C   1 
ATOM   1204 O  O   . VAL   A 1 184 ? -9.922  -12.979 35.340  1.00 75.12  ? 279 VAL   A O   1 
ATOM   1205 C  CB  . VAL   A 1 184 ? -7.955  -11.885 33.208  1.00 75.57  ? 279 VAL   A CB  1 
ATOM   1206 C  CG1 . VAL   A 1 184 ? -6.854  -12.680 33.897  1.00 83.04  ? 279 VAL   A CG1 1 
ATOM   1207 C  CG2 . VAL   A 1 184 ? -7.474  -11.378 31.842  1.00 72.73  ? 279 VAL   A CG2 1 
ATOM   1208 N  N   . ARG   A 1 185 ? -9.336  -14.864 34.242  1.00 75.21  ? 280 ARG   A N   1 
ATOM   1209 C  CA  . ARG   A 1 185 ? -9.511  -15.709 35.418  1.00 83.47  ? 280 ARG   A CA  1 
ATOM   1210 C  C   . ARG   A 1 185 ? -8.217  -16.442 35.760  1.00 87.38  ? 280 ARG   A C   1 
ATOM   1211 O  O   . ARG   A 1 185 ? -8.237  -17.503 36.388  1.00 85.41  ? 280 ARG   A O   1 
ATOM   1212 C  CB  . ARG   A 1 185 ? -10.667 -16.694 35.222  1.00 81.57  ? 280 ARG   A CB  1 
ATOM   1213 C  CG  . ARG   A 1 185 ? -11.154 -17.386 36.518  1.00 83.45  ? 280 ARG   A CG  1 
ATOM   1214 C  CD  . ARG   A 1 185 ? -12.565 -17.958 36.385  1.00 93.72  ? 280 ARG   A CD  1 
ATOM   1215 N  NE  . ARG   A 1 185 ? -12.632 -19.029 35.390  1.00 99.55  ? 280 ARG   A NE  1 
ATOM   1216 C  CZ  . ARG   A 1 185 ? -13.422 -18.990 34.320  1.00 102.70 ? 280 ARG   A CZ  1 
ATOM   1217 N  NH1 . ARG   A 1 185 ? -14.197 -17.932 34.129  1.00 101.36 ? 280 ARG   A NH1 1 
ATOM   1218 N  NH2 . ARG   A 1 185 ? -13.437 -19.984 33.436  1.00 97.02  ? 280 ARG   A NH2 1 
ATOM   1219 N  N   . ASP   A 1 186 ? -7.080  -15.902 35.335  1.00 78.66  ? 281 ASP   A N   1 
ATOM   1220 C  CA  . ASP   A 1 186 ? -5.808  -16.402 35.827  1.00 83.90  ? 281 ASP   A CA  1 
ATOM   1221 C  C   . ASP   A 1 186 ? -5.457  -15.842 37.206  1.00 87.90  ? 281 ASP   A C   1 
ATOM   1222 O  O   . ASP   A 1 186 ? -4.310  -15.988 37.650  1.00 93.74  ? 281 ASP   A O   1 
ATOM   1223 C  CB  . ASP   A 1 186 ? -4.700  -16.087 34.820  1.00 81.62  ? 281 ASP   A CB  1 
ATOM   1224 N  N   . VAL   A 1 187 ? -6.416  -15.212 37.893  1.00 74.92  ? 282 VAL   A N   1 
ATOM   1225 C  CA  . VAL   A 1 187 ? -6.178  -14.560 39.176  1.00 75.40  ? 282 VAL   A CA  1 
ATOM   1226 C  C   . VAL   A 1 187 ? -7.373  -14.780 40.096  1.00 62.90  ? 282 VAL   A C   1 
ATOM   1227 O  O   . VAL   A 1 187 ? -8.479  -15.113 39.664  1.00 60.83  ? 282 VAL   A O   1 
ATOM   1228 C  CB  . VAL   A 1 187 ? -5.904  -13.046 39.031  1.00 68.97  ? 282 VAL   A CB  1 
ATOM   1229 C  CG1 . VAL   A 1 187 ? -4.628  -12.798 38.247  1.00 78.29  ? 282 VAL   A CG1 1 
ATOM   1230 C  CG2 . VAL   A 1 187 ? -7.087  -12.341 38.387  1.00 69.43  ? 282 VAL   A CG2 1 
ATOM   1231 N  N   . VAL   A 1 188 ? -7.133  -14.558 41.385  1.00 48.57  ? 283 VAL   A N   1 
ATOM   1232 C  CA  . VAL   A 1 188 ? -8.143  -14.722 42.418  1.00 56.75  ? 283 VAL   A CA  1 
ATOM   1233 C  C   . VAL   A 1 188 ? -8.076  -13.521 43.352  1.00 57.90  ? 283 VAL   A C   1 
ATOM   1234 O  O   . VAL   A 1 188 ? -6.998  -12.966 43.595  1.00 50.34  ? 283 VAL   A O   1 
ATOM   1235 C  CB  . VAL   A 1 188 ? -7.948  -16.047 43.181  1.00 50.40  ? 283 VAL   A CB  1 
ATOM   1236 C  CG1 . VAL   A 1 188 ? -8.530  -17.188 42.373  1.00 60.73  ? 283 VAL   A CG1 1 
ATOM   1237 C  CG2 . VAL   A 1 188 ? -6.481  -16.287 43.442  1.00 50.09  ? 283 VAL   A CG2 1 
ATOM   1238 N  N   . CYS   A 1 189 ? -9.236  -13.113 43.861  1.00 49.87  ? 284 CYS   A N   1 
ATOM   1239 C  CA  . CYS   A 1 189 ? -9.341  -11.928 44.700  1.00 43.55  ? 284 CYS   A CA  1 
ATOM   1240 C  C   . CYS   A 1 189 ? -8.913  -12.233 46.128  1.00 44.44  ? 284 CYS   A C   1 
ATOM   1241 O  O   . CYS   A 1 189 ? -9.379  -13.206 46.727  1.00 47.52  ? 284 CYS   A O   1 
ATOM   1242 C  CB  . CYS   A 1 189 ? -10.778 -11.414 44.693  1.00 48.41  ? 284 CYS   A CB  1 
ATOM   1243 S  SG  . CYS   A 1 189 ? -11.056 -9.996  45.766  1.00 42.66  ? 284 CYS   A SG  1 
ATOM   1244 N  N   . ASP   A 1 190 ? -8.046  -11.386 46.685  1.00 50.28  ? 285 ASP   A N   1 
ATOM   1245 C  CA  . ASP   A 1 190 ? -7.616  -11.614 48.060  1.00 49.66  ? 285 ASP   A CA  1 
ATOM   1246 C  C   . ASP   A 1 190 ? -8.718  -11.249 49.051  1.00 51.19  ? 285 ASP   A C   1 
ATOM   1247 O  O   . ASP   A 1 190 ? -8.881  -11.918 50.079  1.00 52.44  ? 285 ASP   A O   1 
ATOM   1248 C  CB  . ASP   A 1 190 ? -6.332  -10.831 48.352  1.00 46.13  ? 285 ASP   A CB  1 
ATOM   1249 N  N   . ASN   A 1 191 ? -9.498  -10.207 48.751  1.00 41.33  ? 286 ASN   A N   1 
ATOM   1250 C  CA  . ASN   A 1 191 ? -10.545 -9.781  49.674  1.00 43.36  ? 286 ASN   A CA  1 
ATOM   1251 C  C   . ASN   A 1 191 ? -11.667 -10.811 49.774  1.00 49.09  ? 286 ASN   A C   1 
ATOM   1252 O  O   . ASN   A 1 191 ? -12.113 -11.146 50.879  1.00 42.68  ? 286 ASN   A O   1 
ATOM   1253 C  CB  . ASN   A 1 191 ? -11.108 -8.429  49.248  1.00 45.18  ? 286 ASN   A CB  1 
ATOM   1254 C  CG  . ASN   A 1 191 ? -11.749 -7.697  50.394  1.00 49.60  ? 286 ASN   A CG  1 
ATOM   1255 O  OD1 . ASN   A 1 191 ? -11.231 -7.703  51.512  1.00 54.25  ? 286 ASN   A OD1 1 
ATOM   1256 N  ND2 . ASN   A 1 191 ? -12.889 -7.070  50.135  1.00 58.62  ? 286 ASN   A ND2 1 
ATOM   1257 N  N   . CYS   A 1 192 ? -12.151 -11.309 48.634  1.00 47.74  ? 287 CYS   A N   1 
ATOM   1258 C  CA  . CYS   A 1 192 ? -13.181 -12.340 48.653  1.00 50.93  ? 287 CYS   A CA  1 
ATOM   1259 C  C   . CYS   A 1 192 ? -12.689 -13.642 49.276  1.00 52.23  ? 287 CYS   A C   1 
ATOM   1260 O  O   . CYS   A 1 192 ? -13.501 -14.389 49.834  1.00 53.73  ? 287 CYS   A O   1 
ATOM   1261 C  CB  . CYS   A 1 192 ? -13.699 -12.588 47.234  1.00 45.12  ? 287 CYS   A CB  1 
ATOM   1262 S  SG  . CYS   A 1 192 ? -14.789 -11.287 46.586  1.00 36.05  ? 287 CYS   A SG  1 
ATOM   1263 N  N   . THR   A 1 193 ? -11.382 -13.920 49.215  1.00 45.49  ? 288 THR   A N   1 
ATOM   1264 C  CA  . THR   A 1 193 ? -10.837 -15.151 49.788  1.00 49.29  ? 288 THR   A CA  1 
ATOM   1265 C  C   . THR   A 1 193 ? -10.700 -15.060 51.307  1.00 50.03  ? 288 THR   A C   1 
ATOM   1266 O  O   . THR   A 1 193 ? -11.052 -16.009 52.019  1.00 54.77  ? 288 THR   A O   1 
ATOM   1267 C  CB  . THR   A 1 193 ? -9.484  -15.487 49.144  1.00 53.06  ? 288 THR   A CB  1 
ATOM   1268 O  OG1 . THR   A 1 193 ? -9.677  -15.804 47.759  1.00 52.87  ? 288 THR   A OG1 1 
ATOM   1269 C  CG2 . THR   A 1 193 ? -8.824  -16.676 49.834  1.00 53.31  ? 288 THR   A CG2 1 
ATOM   1270 N  N   . LYS   A 1 194 ? -10.194 -13.937 51.826  1.00 41.07  ? 289 LYS   A N   1 
ATOM   1271 C  CA  . LYS   A 1 194 ? -10.147 -13.760 53.276  1.00 44.22  ? 289 LYS   A CA  1 
ATOM   1272 C  C   . LYS   A 1 194 ? -11.539 -13.786 53.888  1.00 51.26  ? 289 LYS   A C   1 
ATOM   1273 O  O   . LYS   A 1 194 ? -11.723 -14.325 54.985  1.00 61.09  ? 289 LYS   A O   1 
ATOM   1274 C  CB  . LYS   A 1 194 ? -9.442  -12.450 53.633  1.00 52.81  ? 289 LYS   A CB  1 
ATOM   1275 C  CG  . LYS   A 1 194 ? -8.002  -12.369 53.139  1.00 53.75  ? 289 LYS   A CG  1 
ATOM   1276 C  CD  . LYS   A 1 194 ? -7.205  -11.300 53.862  1.00 50.54  ? 289 LYS   A CD  1 
ATOM   1277 C  CE  . LYS   A 1 194 ? -5.949  -10.937 53.083  1.00 62.77  ? 289 LYS   A CE  1 
ATOM   1278 N  NZ  . LYS   A 1 194 ? -6.258  -10.160 51.844  1.00 67.29  ? 289 LYS   A NZ  1 
ATOM   1279 N  N   . ILE   A 1 195 ? -12.529 -13.222 53.194  1.00 49.68  ? 290 ILE   A N   1 
ATOM   1280 C  CA  . ILE   A 1 195 ? -13.885 -13.170 53.730  1.00 46.16  ? 290 ILE   A CA  1 
ATOM   1281 C  C   . ILE   A 1 195 ? -14.502 -14.561 53.753  1.00 51.22  ? 290 ILE   A C   1 
ATOM   1282 O  O   . ILE   A 1 195 ? -15.088 -14.979 54.760  1.00 52.30  ? 290 ILE   A O   1 
ATOM   1283 C  CB  . ILE   A 1 195 ? -14.727 -12.170 52.913  1.00 48.37  ? 290 ILE   A CB  1 
ATOM   1284 C  CG1 . ILE   A 1 195 ? -14.346 -10.739 53.297  1.00 44.99  ? 290 ILE   A CG1 1 
ATOM   1285 C  CG2 . ILE   A 1 195 ? -16.221 -12.413 53.086  1.00 39.15  ? 290 ILE   A CG2 1 
ATOM   1286 C  CD1 . ILE   A 1 195 ? -14.784 -9.708  52.300  1.00 51.54  ? 290 ILE   A CD1 1 
ATOM   1287 N  N   . GLU   A 1 196 ? -14.358 -15.307 52.653  1.00 56.93  ? 291 GLU   A N   1 
ATOM   1288 C  CA  . GLU   A 1 196 ? -14.901 -16.659 52.563  1.00 59.10  ? 291 GLU   A CA  1 
ATOM   1289 C  C   . GLU   A 1 196 ? -14.271 -17.614 53.573  1.00 49.58  ? 291 GLU   A C   1 
ATOM   1290 O  O   . GLU   A 1 196 ? -14.885 -18.630 53.911  1.00 45.00  ? 291 GLU   A O   1 
ATOM   1291 C  CB  . GLU   A 1 196 ? -14.721 -17.199 51.139  1.00 56.52  ? 291 GLU   A CB  1 
ATOM   1292 C  CG  . GLU   A 1 196 ? -15.873 -16.862 50.186  1.00 78.90  ? 291 GLU   A CG  1 
ATOM   1293 C  CD  . GLU   A 1 196 ? -15.467 -16.872 48.709  1.00 79.66  ? 291 GLU   A CD  1 
ATOM   1294 O  OE1 . GLU   A 1 196 ? -14.689 -17.765 48.304  1.00 71.45  ? 291 GLU   A OE1 1 
ATOM   1295 O  OE2 . GLU   A 1 196 ? -15.936 -15.988 47.952  1.00 78.67  ? 291 GLU   A OE2 1 
ATOM   1296 N  N   . ALA   A 1 197 ? -13.071 -17.318 54.069  1.00 43.39  ? 292 ALA   A N   1 
ATOM   1297 C  CA  . ALA   A 1 197 ? -12.464 -18.137 55.106  1.00 49.73  ? 292 ALA   A CA  1 
ATOM   1298 C  C   . ALA   A 1 197 ? -12.906 -17.718 56.503  1.00 61.92  ? 292 ALA   A C   1 
ATOM   1299 O  O   . ALA   A 1 197 ? -12.216 -18.031 57.485  1.00 56.81  ? 292 ALA   A O   1 
ATOM   1300 C  CB  . ALA   A 1 197 ? -10.940 -18.102 54.988  1.00 38.07  ? 292 ALA   A CB  1 
ATOM   1301 N  N   . LYS   A 1 198 ? -14.048 -17.036 56.603  1.00 57.00  ? 293 LYS   A N   1 
ATOM   1302 C  CA  . LYS   A 1 198 ? -14.602 -16.572 57.863  1.00 47.79  ? 293 LYS   A CA  1 
ATOM   1303 C  C   . LYS   A 1 198 ? -13.516 -15.813 58.602  1.00 52.91  ? 293 LYS   A C   1 
ATOM   1304 O  O   . LYS   A 1 198 ? -12.767 -15.056 57.981  1.00 50.03  ? 293 LYS   A O   1 
ATOM   1305 C  CB  . LYS   A 1 198 ? -15.145 -17.740 58.692  1.00 45.05  ? 293 LYS   A CB  1 
ATOM   1306 N  N   . GLY   A 1 203 ? -16.267 -20.073 60.795  1.00 71.01  ? 298 GLY   A N   1 
ATOM   1307 C  CA  . GLY   A 1 203 ? -17.246 -20.180 61.863  1.00 62.71  ? 298 GLY   A CA  1 
ATOM   1308 C  C   . GLY   A 1 203 ? -18.692 -19.971 61.441  1.00 78.98  ? 298 GLY   A C   1 
ATOM   1309 O  O   . GLY   A 1 203 ? -19.592 -19.940 62.280  1.00 85.55  ? 298 GLY   A O   1 
ATOM   1310 N  N   . GLU   A 1 204 ? -18.922 -19.832 60.136  1.00 83.26  ? 299 GLU   A N   1 
ATOM   1311 C  CA  . GLU   A 1 204 ? -20.263 -19.562 59.629  1.00 80.74  ? 299 GLU   A CA  1 
ATOM   1312 C  C   . GLU   A 1 204 ? -20.550 -20.405 58.393  1.00 76.40  ? 299 GLU   A C   1 
ATOM   1313 O  O   . GLU   A 1 204 ? -20.071 -21.538 58.285  1.00 78.91  ? 299 GLU   A O   1 
ATOM   1314 C  CB  . GLU   A 1 204 ? -20.423 -18.072 59.312  1.00 68.73  ? 299 GLU   A CB  1 
ATOM   1315 N  N   . LYS   A 1 205 ? -21.331 -19.866 57.458  1.00 73.68  ? 300 LYS   A N   1 
ATOM   1316 C  CA  . LYS   A 1 205 ? -21.646 -20.546 56.205  1.00 76.33  ? 300 LYS   A CA  1 
ATOM   1317 C  C   . LYS   A 1 205 ? -21.476 -19.549 55.068  1.00 74.64  ? 300 LYS   A C   1 
ATOM   1318 O  O   . LYS   A 1 205 ? -22.293 -18.637 54.910  1.00 78.29  ? 300 LYS   A O   1 
ATOM   1319 C  CB  . LYS   A 1 205 ? -23.064 -21.119 56.224  1.00 81.19  ? 300 LYS   A CB  1 
ATOM   1320 N  N   . VAL   A 1 206 ? -20.418 -19.720 54.280  1.00 85.18  ? 301 VAL   A N   1 
ATOM   1321 C  CA  . VAL   A 1 206 ? -20.089 -18.820 53.182  1.00 86.08  ? 301 VAL   A CA  1 
ATOM   1322 C  C   . VAL   A 1 206 ? -20.045 -19.632 51.894  1.00 81.51  ? 301 VAL   A C   1 
ATOM   1323 O  O   . VAL   A 1 206 ? -19.416 -20.695 51.845  1.00 65.27  ? 301 VAL   A O   1 
ATOM   1324 C  CB  . VAL   A 1 206 ? -18.751 -18.097 53.424  1.00 70.57  ? 301 VAL   A CB  1 
ATOM   1325 N  N   . GLU   A 1 207 ? -20.720 -19.134 50.859  1.00 82.33  ? 302 GLU   A N   1 
ATOM   1326 C  CA  . GLU   A 1 207 ? -20.736 -19.771 49.550  1.00 74.99  ? 302 GLU   A CA  1 
ATOM   1327 C  C   . GLU   A 1 207 ? -19.676 -19.142 48.657  1.00 78.40  ? 302 GLU   A C   1 
ATOM   1328 O  O   . GLU   A 1 207 ? -19.508 -17.918 48.641  1.00 78.30  ? 302 GLU   A O   1 
ATOM   1329 C  CB  . GLU   A 1 207 ? -22.111 -19.646 48.890  1.00 54.45  ? 302 GLU   A CB  1 
ATOM   1330 N  N   . HIS   A 1 208 ? -18.965 -19.983 47.913  1.00 76.23  ? 303 HIS   A N   1 
ATOM   1331 C  CA  . HIS   A 1 208 ? -17.898 -19.508 47.042  1.00 70.32  ? 303 HIS   A CA  1 
ATOM   1332 C  C   . HIS   A 1 208 ? -18.499 -18.878 45.789  1.00 72.00  ? 303 HIS   A C   1 
ATOM   1333 O  O   . HIS   A 1 208 ? -19.209 -19.547 45.028  1.00 63.35  ? 303 HIS   A O   1 
ATOM   1334 C  CB  . HIS   A 1 208 ? -16.958 -20.656 46.685  1.00 55.86  ? 303 HIS   A CB  1 
ATOM   1335 C  CG  . HIS   A 1 208 ? -15.894 -20.281 45.704  1.00 66.94  ? 303 HIS   A CG  1 
ATOM   1336 N  ND1 . HIS   A 1 208 ? -14.831 -19.466 46.031  1.00 72.19  ? 303 HIS   A ND1 1 
ATOM   1337 C  CD2 . HIS   A 1 208 ? -15.729 -20.609 44.400  1.00 65.24  ? 303 HIS   A CD2 1 
ATOM   1338 C  CE1 . HIS   A 1 208 ? -14.059 -19.307 44.971  1.00 64.83  ? 303 HIS   A CE1 1 
ATOM   1339 N  NE2 . HIS   A 1 208 ? -14.582 -19.989 43.968  1.00 68.42  ? 303 HIS   A NE2 1 
ATOM   1340 N  N   . GLN   A 1 209 ? -18.229 -17.590 45.586  1.00 66.13  ? 304 GLN   A N   1 
ATOM   1341 C  CA  . GLN   A 1 209 ? -18.672 -16.892 44.388  1.00 68.99  ? 304 GLN   A CA  1 
ATOM   1342 C  C   . GLN   A 1 209 ? -17.668 -17.096 43.262  1.00 62.78  ? 304 GLN   A C   1 
ATOM   1343 O  O   . GLN   A 1 209 ? -16.460 -17.195 43.493  1.00 61.31  ? 304 GLN   A O   1 
ATOM   1344 C  CB  . GLN   A 1 209 ? -18.849 -15.396 44.663  1.00 65.11  ? 304 GLN   A CB  1 
ATOM   1345 N  N   . ARG   A 1 210 ? -18.181 -17.165 42.034  1.00 64.22  ? 305 ARG   A N   1 
ATOM   1346 C  CA  . ARG   A 1 210 ? -17.323 -17.408 40.881  1.00 61.58  ? 305 ARG   A CA  1 
ATOM   1347 C  C   . ARG   A 1 210 ? -16.316 -16.272 40.733  1.00 63.00  ? 305 ARG   A C   1 
ATOM   1348 O  O   . ARG   A 1 210 ? -16.688 -15.095 40.696  1.00 63.39  ? 305 ARG   A O   1 
ATOM   1349 C  CB  . ARG   A 1 210 ? -18.159 -17.558 39.609  1.00 56.32  ? 305 ARG   A CB  1 
ATOM   1350 C  CG  . ARG   A 1 210 ? -17.450 -18.301 38.488  1.00 65.01  ? 305 ARG   A CG  1 
ATOM   1351 C  CD  . ARG   A 1 210 ? -17.973 -17.918 37.106  1.00 70.21  ? 305 ARG   A CD  1 
ATOM   1352 N  NE  . ARG   A 1 210 ? -19.193 -18.640 36.744  1.00 79.43  ? 305 ARG   A NE  1 
ATOM   1353 C  CZ  . ARG   A 1 210 ? -19.465 -19.079 35.517  1.00 84.27  ? 305 ARG   A CZ  1 
ATOM   1354 N  NH1 . ARG   A 1 210 ? -18.598 -18.877 34.533  1.00 80.75  ? 305 ARG   A NH1 1 
ATOM   1355 N  NH2 . ARG   A 1 210 ? -20.604 -19.720 35.272  1.00 78.56  ? 305 ARG   A NH2 1 
ATOM   1356 N  N   . THR   A 1 211 ? -15.036 -16.632 40.669  1.00 60.11  ? 306 THR   A N   1 
ATOM   1357 C  CA  . THR   A 1 211 ? -13.945 -15.667 40.542  1.00 64.91  ? 306 THR   A CA  1 
ATOM   1358 C  C   . THR   A 1 211 ? -14.007 -15.016 39.164  1.00 69.28  ? 306 THR   A C   1 
ATOM   1359 O  O   . THR   A 1 211 ? -13.659 -15.629 38.152  1.00 70.35  ? 306 THR   A O   1 
ATOM   1360 C  CB  . THR   A 1 211 ? -12.606 -16.358 40.773  1.00 60.68  ? 306 THR   A CB  1 
ATOM   1361 O  OG1 . THR   A 1 211 ? -12.738 -17.294 41.850  1.00 65.20  ? 306 THR   A OG1 1 
ATOM   1362 C  CG2 . THR   A 1 211 ? -11.529 -15.341 41.132  1.00 70.18  ? 306 THR   A CG2 1 
ATOM   1363 N  N   . THR   A 1 212 ? -14.465 -13.765 39.124  1.00 57.46  ? 307 THR   A N   1 
ATOM   1364 C  CA  . THR   A 1 212 ? -14.615 -12.997 37.894  1.00 61.39  ? 307 THR   A CA  1 
ATOM   1365 C  C   . THR   A 1 212 ? -13.802 -11.717 38.035  1.00 61.88  ? 307 THR   A C   1 
ATOM   1366 O  O   . THR   A 1 212 ? -14.063 -10.904 38.931  1.00 53.13  ? 307 THR   A O   1 
ATOM   1367 C  CB  . THR   A 1 212 ? -16.091 -12.684 37.617  1.00 60.22  ? 307 THR   A CB  1 
ATOM   1368 O  OG1 . THR   A 1 212 ? -16.856 -13.894 37.676  1.00 68.37  ? 307 THR   A OG1 1 
ATOM   1369 C  CG2 . THR   A 1 212 ? -16.272 -12.044 36.247  1.00 54.82  ? 307 THR   A CG2 1 
ATOM   1370 N  N   . PHE   A 1 213 ? -12.811 -11.546 37.165  1.00 62.72  ? 308 PHE   A N   1 
ATOM   1371 C  CA  . PHE   A 1 213 ? -11.937 -10.381 37.188  1.00 62.53  ? 308 PHE   A CA  1 
ATOM   1372 C  C   . PHE   A 1 213 ? -11.977 -9.697  35.829  1.00 64.60  ? 308 PHE   A C   1 
ATOM   1373 O  O   . PHE   A 1 213 ? -12.003 -10.362 34.789  1.00 67.56  ? 308 PHE   A O   1 
ATOM   1374 C  CB  . PHE   A 1 213 ? -10.494 -10.768 37.535  1.00 55.10  ? 308 PHE   A CB  1 
ATOM   1375 C  CG  . PHE   A 1 213 ? -10.125 -10.539 38.971  1.00 54.63  ? 308 PHE   A CG  1 
ATOM   1376 C  CD1 . PHE   A 1 213 ? -9.654  -9.306  39.387  1.00 56.19  ? 308 PHE   A CD1 1 
ATOM   1377 C  CD2 . PHE   A 1 213 ? -10.221 -11.564 39.901  1.00 57.86  ? 308 PHE   A CD2 1 
ATOM   1378 C  CE1 . PHE   A 1 213 ? -9.298  -9.091  40.706  1.00 55.83  ? 308 PHE   A CE1 1 
ATOM   1379 C  CE2 . PHE   A 1 213 ? -9.869  -11.355 41.224  1.00 51.39  ? 308 PHE   A CE2 1 
ATOM   1380 C  CZ  . PHE   A 1 213 ? -9.405  -10.116 41.625  1.00 54.22  ? 308 PHE   A CZ  1 
ATOM   1381 N  N   . VAL   A 1 214 ? -11.994 -8.368  35.839  1.00 56.86  ? 309 VAL   A N   1 
ATOM   1382 C  CA  . VAL   A 1 214 ? -11.948 -7.575  34.618  1.00 65.37  ? 309 VAL   A CA  1 
ATOM   1383 C  C   . VAL   A 1 214 ? -10.669 -6.751  34.633  1.00 59.32  ? 309 VAL   A C   1 
ATOM   1384 O  O   . VAL   A 1 214 ? -10.282 -6.203  35.671  1.00 62.69  ? 309 VAL   A O   1 
ATOM   1385 C  CB  . VAL   A 1 214 ? -13.191 -6.675  34.460  1.00 54.71  ? 309 VAL   A CB  1 
ATOM   1386 C  CG1 . VAL   A 1 214 ? -13.272 -5.659  35.582  1.00 70.45  ? 309 VAL   A CG1 1 
ATOM   1387 C  CG2 . VAL   A 1 214 ? -13.156 -5.974  33.121  1.00 57.49  ? 309 VAL   A CG2 1 
ATOM   1388 N  N   . LYS   A 1 215 ? -10.000 -6.684  33.490  1.00 60.94  ? 310 LYS   A N   1 
ATOM   1389 C  CA  . LYS   A 1 215 ? -8.722  -5.990  33.376  1.00 60.87  ? 310 LYS   A CA  1 
ATOM   1390 C  C   . LYS   A 1 215 ? -8.988  -4.616  32.772  1.00 56.82  ? 310 LYS   A C   1 
ATOM   1391 O  O   . LYS   A 1 215 ? -9.167  -4.483  31.560  1.00 64.40  ? 310 LYS   A O   1 
ATOM   1392 C  CB  . LYS   A 1 215 ? -7.741  -6.804  32.539  1.00 56.74  ? 310 LYS   A CB  1 
ATOM   1393 N  N   . GLN   A 1 216 ? -9.029  -3.596  33.626  1.00 48.61  ? 311 GLN   A N   1 
ATOM   1394 C  CA  . GLN   A 1 216 ? -9.268  -2.230  33.179  1.00 57.98  ? 311 GLN   A CA  1 
ATOM   1395 C  C   . GLN   A 1 216 ? -7.957  -1.626  32.691  1.00 55.85  ? 311 GLN   A C   1 
ATOM   1396 O  O   . GLN   A 1 216 ? -6.974  -1.571  33.439  1.00 50.98  ? 311 GLN   A O   1 
ATOM   1397 C  CB  . GLN   A 1 216 ? -9.867  -1.398  34.309  1.00 53.08  ? 311 GLN   A CB  1 
ATOM   1398 C  CG  . GLN   A 1 216 ? -10.852 -2.173  35.154  1.00 60.68  ? 311 GLN   A CG  1 
ATOM   1399 C  CD  . GLN   A 1 216 ? -11.900 -1.291  35.792  1.00 71.07  ? 311 GLN   A CD  1 
ATOM   1400 O  OE1 . GLN   A 1 216 ? -11.610 -0.175  36.229  1.00 70.26  ? 311 GLN   A OE1 1 
ATOM   1401 N  NE2 . GLN   A 1 216 ? -13.129 -1.792  35.859  1.00 75.27  ? 311 GLN   A NE2 1 
ATOM   1402 N  N   . LEU   A 1 217 ? -7.944  -1.184  31.438  1.00 56.10  ? 312 LEU   A N   1 
ATOM   1403 C  CA  . LEU   A 1 217 ? -6.755  -0.661  30.784  1.00 48.78  ? 312 LEU   A CA  1 
ATOM   1404 C  C   . LEU   A 1 217 ? -6.903  0.829   30.546  1.00 40.90  ? 312 LEU   A C   1 
ATOM   1405 O  O   . LEU   A 1 217 ? -8.012  1.341   30.391  1.00 51.44  ? 312 LEU   A O   1 
ATOM   1406 C  CB  . LEU   A 1 217 ? -6.516  -1.347  29.439  1.00 55.49  ? 312 LEU   A CB  1 
ATOM   1407 C  CG  . LEU   A 1 217 ? -6.302  -2.848  29.496  1.00 51.72  ? 312 LEU   A CG  1 
ATOM   1408 C  CD1 . LEU   A 1 217 ? -6.164  -3.424  28.103  1.00 41.41  ? 312 LEU   A CD1 1 
ATOM   1409 C  CD2 . LEU   A 1 217 ? -5.077  -3.089  30.313  1.00 55.20  ? 312 LEU   A CD2 1 
ATOM   1410 N  N   . LYS   A 1 218 ? -5.771  1.521   30.503  1.00 41.22  ? 313 LYS   A N   1 
ATOM   1411 C  CA  . LYS   A 1 218 ? -5.759  2.921   30.099  1.00 52.20  ? 313 LYS   A CA  1 
ATOM   1412 C  C   . LYS   A 1 218 ? -4.474  3.170   29.333  1.00 41.78  ? 313 LYS   A C   1 
ATOM   1413 O  O   . LYS   A 1 218 ? -3.383  2.973   29.873  1.00 44.81  ? 313 LYS   A O   1 
ATOM   1414 C  CB  . LYS   A 1 218 ? -5.878  3.859   31.308  1.00 59.04  ? 313 LYS   A CB  1 
ATOM   1415 C  CG  . LYS   A 1 218 ? -7.329  4.249   31.657  1.00 61.40  ? 313 LYS   A CG  1 
ATOM   1416 C  CD  . LYS   A 1 218 ? -8.045  4.906   30.477  1.00 61.23  ? 313 LYS   A CD  1 
ATOM   1417 N  N   . LEU   A 1 219 ? -4.607  3.572   28.075  1.00 46.17  ? 314 LEU   A N   1 
ATOM   1418 C  CA  . LEU   A 1 219 ? -3.448  3.797   27.227  1.00 45.24  ? 314 LEU   A CA  1 
ATOM   1419 C  C   . LEU   A 1 219 ? -2.790  5.126   27.570  1.00 45.80  ? 314 LEU   A C   1 
ATOM   1420 O  O   . LEU   A 1 219 ? -3.466  6.152   27.688  1.00 44.64  ? 314 LEU   A O   1 
ATOM   1421 C  CB  . LEU   A 1 219 ? -3.852  3.775   25.755  1.00 43.86  ? 314 LEU   A CB  1 
ATOM   1422 C  CG  . LEU   A 1 219 ? -4.576  2.518   25.278  1.00 35.29  ? 314 LEU   A CG  1 
ATOM   1423 C  CD1 . LEU   A 1 219 ? -5.836  2.904   24.510  1.00 47.42  ? 314 LEU   A CD1 1 
ATOM   1424 C  CD2 . LEU   A 1 219 ? -3.658  1.650   24.439  1.00 36.29  ? 314 LEU   A CD2 1 
ATOM   1425 N  N   . GLY   A 1 220 ? -1.468  5.103   27.722  1.00 50.19  ? 315 GLY   A N   1 
ATOM   1426 C  CA  . GLY   A 1 220 ? -0.710  6.300   28.029  1.00 44.07  ? 315 GLY   A CA  1 
ATOM   1427 C  C   . GLY   A 1 220 ? -0.259  7.056   26.795  1.00 47.68  ? 315 GLY   A C   1 
ATOM   1428 O  O   . GLY   A 1 220 ? -0.899  8.030   26.385  1.00 72.34  ? 315 GLY   A O   1 
ATOM   1429 N  N   . LYS   A 1 221 ? 0.848   6.623   26.199  1.00 49.23  ? 316 LYS   A N   1 
ATOM   1430 C  CA  . LYS   A 1 221 ? 1.368   7.219   24.975  1.00 48.64  ? 316 LYS   A CA  1 
ATOM   1431 C  C   . LYS   A 1 221 ? 0.786   6.476   23.780  1.00 46.51  ? 316 LYS   A C   1 
ATOM   1432 O  O   . LYS   A 1 221 ? 0.931   5.253   23.675  1.00 42.19  ? 316 LYS   A O   1 
ATOM   1433 C  CB  . LYS   A 1 221 ? 2.895   7.164   24.940  1.00 42.33  ? 316 LYS   A CB  1 
ATOM   1434 N  N   . LEU   A 1 222 ? 0.122   7.216   22.886  1.00 47.11  ? 317 LEU   A N   1 
ATOM   1435 C  CA  . LEU   A 1 222 ? -0.401  6.605   21.668  1.00 39.28  ? 317 LEU   A CA  1 
ATOM   1436 C  C   . LEU   A 1 222 ? 0.669   6.617   20.587  1.00 36.79  ? 317 LEU   A C   1 
ATOM   1437 O  O   . LEU   A 1 222 ? 1.215   7.685   20.279  1.00 46.52  ? 317 LEU   A O   1 
ATOM   1438 C  CB  . LEU   A 1 222 ? -1.630  7.348   21.172  1.00 42.33  ? 317 LEU   A CB  1 
ATOM   1439 C  CG  . LEU   A 1 222 ? -2.877  7.195   22.034  1.00 46.22  ? 317 LEU   A CG  1 
ATOM   1440 C  CD1 . LEU   A 1 222 ? -3.820  8.349   21.776  1.00 45.61  ? 317 LEU   A CD1 1 
ATOM   1441 C  CD2 . LEU   A 1 222 ? -3.549  5.868   21.770  1.00 42.53  ? 317 LEU   A CD2 1 
ATOM   1442 N  N   . PRO   A 1 223 ? 0.989   5.470   19.995  1.00 33.11  ? 318 PRO   A N   1 
ATOM   1443 C  CA  . PRO   A 1 223 ? 2.045   5.430   18.980  1.00 39.08  ? 318 PRO   A CA  1 
ATOM   1444 C  C   . PRO   A 1 223 ? 1.593   6.103   17.702  1.00 36.52  ? 318 PRO   A C   1 
ATOM   1445 O  O   . PRO   A 1 223 ? 0.407   6.242   17.406  1.00 33.44  ? 318 PRO   A O   1 
ATOM   1446 C  CB  . PRO   A 1 223 ? 2.269   3.936   18.750  1.00 32.42  ? 318 PRO   A CB  1 
ATOM   1447 C  CG  . PRO   A 1 223 ? 0.939   3.333   19.067  1.00 40.29  ? 318 PRO   A CG  1 
ATOM   1448 C  CD  . PRO   A 1 223 ? 0.381   4.151   20.210  1.00 31.46  ? 318 PRO   A CD  1 
ATOM   1449 N  N   . GLN   A 1 224 ? 2.562   6.510   16.915  1.00 38.81  ? 319 GLN   A N   1 
ATOM   1450 C  CA  . GLN   A 1 224 ? 2.172   7.207   15.711  1.00 39.23  ? 319 GLN   A CA  1 
ATOM   1451 C  C   . GLN   A 1 224 ? 1.834   6.225   14.585  1.00 41.12  ? 319 GLN   A C   1 
ATOM   1452 O  O   . GLN   A 1 224 ? 1.106   6.573   13.648  1.00 38.13  ? 319 GLN   A O   1 
ATOM   1453 C  CB  . GLN   A 1 224 ? 3.286   8.179   15.377  1.00 42.72  ? 319 GLN   A CB  1 
ATOM   1454 C  CG  . GLN   A 1 224 ? 2.862   9.339   14.555  1.00 54.11  ? 319 GLN   A CG  1 
ATOM   1455 C  CD  . GLN   A 1 224 ? 3.177   9.134   13.145  1.00 48.39  ? 319 GLN   A CD  1 
ATOM   1456 O  OE1 . GLN   A 1 224 ? 2.342   9.291   12.275  1.00 53.99  ? 319 GLN   A OE1 1 
ATOM   1457 N  NE2 . GLN   A 1 224 ? 4.407   8.871   12.882  1.00 58.85  ? 319 GLN   A NE2 1 
ATOM   1458 N  N   . CYS   A 1 225 ? 2.294   4.980   14.685  1.00 37.47  ? 320 CYS   A N   1 
ATOM   1459 C  CA  . CYS   A 1 225 ? 1.813   3.899   13.828  1.00 36.76  ? 320 CYS   A CA  1 
ATOM   1460 C  C   . CYS   A 1 225 ? 1.048   2.908   14.693  1.00 39.04  ? 320 CYS   A C   1 
ATOM   1461 O  O   . CYS   A 1 225 ? 1.628   2.267   15.574  1.00 42.90  ? 320 CYS   A O   1 
ATOM   1462 C  CB  . CYS   A 1 225 ? 2.960   3.213   13.097  1.00 32.95  ? 320 CYS   A CB  1 
ATOM   1463 S  SG  . CYS   A 1 225 ? 3.599   4.208   11.763  1.00 49.75  ? 320 CYS   A SG  1 
ATOM   1464 N  N   . LEU   A 1 226 ? -0.245  2.776   14.454  1.00 30.90  ? 321 LEU   A N   1 
ATOM   1465 C  CA  . LEU   A 1 226 ? -1.078  1.942   15.300  1.00 31.24  ? 321 LEU   A CA  1 
ATOM   1466 C  C   . LEU   A 1 226 ? -1.375  0.628   14.594  1.00 33.78  ? 321 LEU   A C   1 
ATOM   1467 O  O   . LEU   A 1 226 ? -1.840  0.624   13.451  1.00 31.14  ? 321 LEU   A O   1 
ATOM   1468 C  CB  . LEU   A 1 226 ? -2.370  2.672   15.653  1.00 32.46  ? 321 LEU   A CB  1 
ATOM   1469 C  CG  . LEU   A 1 226 ? -3.331  1.884   16.537  1.00 37.55  ? 321 LEU   A CG  1 
ATOM   1470 C  CD1 . LEU   A 1 226 ? -2.635  1.382   17.806  1.00 30.24  ? 321 LEU   A CD1 1 
ATOM   1471 C  CD2 . LEU   A 1 226 ? -4.542  2.750   16.864  1.00 30.29  ? 321 LEU   A CD2 1 
ATOM   1472 N  N   . CYS   A 1 227 ? -1.100  -0.484  15.268  1.00 29.41  ? 322 CYS   A N   1 
ATOM   1473 C  CA  . CYS   A 1 227 ? -1.495  -1.800  14.781  1.00 32.53  ? 322 CYS   A CA  1 
ATOM   1474 C  C   . CYS   A 1 227 ? -2.556  -2.393  15.697  1.00 31.51  ? 322 CYS   A C   1 
ATOM   1475 O  O   . CYS   A 1 227 ? -2.322  -2.576  16.896  1.00 32.34  ? 322 CYS   A O   1 
ATOM   1476 C  CB  . CYS   A 1 227 ? -0.299  -2.743  14.672  1.00 30.39  ? 322 CYS   A CB  1 
ATOM   1477 S  SG  . CYS   A 1 227 ? -0.758  -4.406  14.112  1.00 36.57  ? 322 CYS   A SG  1 
ATOM   1478 N  N   . ILE   A 1 228 ? -3.707  -2.718  15.120  1.00 29.07  ? 323 ILE   A N   1 
ATOM   1479 C  CA  . ILE   A 1 228 ? -4.824  -3.323  15.832  1.00 32.93  ? 323 ILE   A CA  1 
ATOM   1480 C  C   . ILE   A 1 228 ? -4.980  -4.747  15.319  1.00 33.52  ? 323 ILE   A C   1 
ATOM   1481 O  O   . ILE   A 1 228 ? -5.092  -4.970  14.106  1.00 41.75  ? 323 ILE   A O   1 
ATOM   1482 C  CB  . ILE   A 1 228 ? -6.115  -2.511  15.636  1.00 40.50  ? 323 ILE   A CB  1 
ATOM   1483 C  CG1 . ILE   A 1 228 ? -6.025  -1.194  16.427  1.00 31.40  ? 323 ILE   A CG1 1 
ATOM   1484 C  CG2 . ILE   A 1 228 ? -7.328  -3.343  16.025  1.00 34.26  ? 323 ILE   A CG2 1 
ATOM   1485 C  CD1 . ILE   A 1 228 ? -7.260  -0.338  16.401  1.00 20.71  ? 323 ILE   A CD1 1 
ATOM   1486 N  N   . HIS   A 1 229 ? -4.983  -5.711  16.233  1.00 35.88  ? 324 HIS   A N   1 
ATOM   1487 C  CA  . HIS   A 1 229 ? -5.083  -7.124  15.890  1.00 31.36  ? 324 HIS   A CA  1 
ATOM   1488 C  C   . HIS   A 1 229 ? -6.401  -7.669  16.420  1.00 36.61  ? 324 HIS   A C   1 
ATOM   1489 O  O   . HIS   A 1 229 ? -6.719  -7.501  17.603  1.00 39.32  ? 324 HIS   A O   1 
ATOM   1490 C  CB  . HIS   A 1 229 ? -3.898  -7.908  16.462  1.00 30.13  ? 324 HIS   A CB  1 
ATOM   1491 C  CG  . HIS   A 1 229 ? -4.025  -9.397  16.349  1.00 33.40  ? 324 HIS   A CG  1 
ATOM   1492 N  ND1 . HIS   A 1 229 ? -4.347  -10.197 17.425  1.00 31.51  ? 324 HIS   A ND1 1 
ATOM   1493 C  CD2 . HIS   A 1 229 ? -3.838  -10.236 15.301  1.00 36.80  ? 324 HIS   A CD2 1 
ATOM   1494 C  CE1 . HIS   A 1 229 ? -4.369  -11.461 17.042  1.00 32.78  ? 324 HIS   A CE1 1 
ATOM   1495 N  NE2 . HIS   A 1 229 ? -4.066  -11.513 15.757  1.00 30.02  ? 324 HIS   A NE2 1 
ATOM   1496 N  N   . LEU   A 1 230 ? -7.176  -8.293  15.542  1.00 34.02  ? 325 LEU   A N   1 
ATOM   1497 C  CA  . LEU   A 1 230 ? -8.425  -8.933  15.930  1.00 34.11  ? 325 LEU   A CA  1 
ATOM   1498 C  C   . LEU   A 1 230 ? -8.154  -10.418 16.127  1.00 30.77  ? 325 LEU   A C   1 
ATOM   1499 O  O   . LEU   A 1 230 ? -7.698  -11.102 15.202  1.00 34.44  ? 325 LEU   A O   1 
ATOM   1500 C  CB  . LEU   A 1 230 ? -9.508  -8.696  14.879  1.00 33.49  ? 325 LEU   A CB  1 
ATOM   1501 C  CG  . LEU   A 1 230 ? -9.835  -7.216  14.641  1.00 33.12  ? 325 LEU   A CG  1 
ATOM   1502 C  CD1 . LEU   A 1 230 ? -10.869 -7.035  13.534  1.00 32.02  ? 325 LEU   A CD1 1 
ATOM   1503 C  CD2 . LEU   A 1 230 ? -10.293 -6.539  15.925  1.00 35.68  ? 325 LEU   A CD2 1 
ATOM   1504 N  N   . GLN   A 1 231 ? -8.399  -10.903 17.341  1.00 33.15  ? 326 GLN   A N   1 
ATOM   1505 C  CA  . GLN   A 1 231 ? -8.128  -12.296 17.668  1.00 39.50  ? 326 GLN   A CA  1 
ATOM   1506 C  C   . GLN   A 1 231 ? -9.148  -13.204 16.996  1.00 39.94  ? 326 GLN   A C   1 
ATOM   1507 O  O   . GLN   A 1 231 ? -10.254 -13.398 17.512  1.00 41.40  ? 326 GLN   A O   1 
ATOM   1508 C  CB  . GLN   A 1 231 ? -8.130  -12.494 19.185  1.00 37.92  ? 326 GLN   A CB  1 
ATOM   1509 C  CG  . GLN   A 1 231 ? -7.033  -11.728 19.900  1.00 45.88  ? 326 GLN   A CG  1 
ATOM   1510 C  CD  . GLN   A 1 231 ? -7.283  -11.610 21.390  1.00 58.35  ? 326 GLN   A CD  1 
ATOM   1511 O  OE1 . GLN   A 1 231 ? -8.367  -11.957 21.878  1.00 59.17  ? 326 GLN   A OE1 1 
ATOM   1512 N  NE2 . GLN   A 1 231 ? -6.284  -11.111 22.126  1.00 47.31  ? 326 GLN   A NE2 1 
ATOM   1513 N  N   . ARG   A 1 232 ? -8.792  -13.752 15.837  1.00 29.68  ? 327 ARG   A N   1 
ATOM   1514 C  CA  . ARG   A 1 232 ? -9.661  -14.660 15.107  1.00 31.84  ? 327 ARG   A CA  1 
ATOM   1515 C  C   . ARG   A 1 232 ? -9.311  -16.118 15.341  1.00 36.72  ? 327 ARG   A C   1 
ATOM   1516 O  O   . ARG   A 1 232 ? -10.010 -16.999 14.831  1.00 33.92  ? 327 ARG   A O   1 
ATOM   1517 C  CB  . ARG   A 1 232 ? -9.614  -14.361 13.606  1.00 33.53  ? 327 ARG   A CB  1 
ATOM   1518 C  CG  . ARG   A 1 232 ? -10.068 -12.956 13.240  1.00 35.60  ? 327 ARG   A CG  1 
ATOM   1519 C  CD  . ARG   A 1 232 ? -10.279 -12.811 11.745  1.00 27.85  ? 327 ARG   A CD  1 
ATOM   1520 N  NE  . ARG   A 1 232 ? -10.789 -11.483 11.429  1.00 32.98  ? 327 ARG   A NE  1 
ATOM   1521 C  CZ  . ARG   A 1 232 ? -12.070 -11.134 11.493  1.00 36.03  ? 327 ARG   A CZ  1 
ATOM   1522 N  NH1 . ARG   A 1 232 ? -12.990 -12.024 11.841  1.00 30.19  ? 327 ARG   A NH1 1 
ATOM   1523 N  NH2 . ARG   A 1 232 ? -12.432 -9.893  11.200  1.00 38.82  ? 327 ARG   A NH2 1 
ATOM   1524 N  N   . LEU   A 1 233 ? -8.256  -16.397 16.098  1.00 34.93  ? 328 LEU   A N   1 
ATOM   1525 C  CA  . LEU   A 1 233 ? -7.821  -17.760 16.368  1.00 35.89  ? 328 LEU   A CA  1 
ATOM   1526 C  C   . LEU   A 1 233 ? -8.315  -18.198 17.743  1.00 29.31  ? 328 LEU   A C   1 
ATOM   1527 O  O   . LEU   A 1 233 ? -7.942  -17.605 18.758  1.00 42.55  ? 328 LEU   A O   1 
ATOM   1528 C  CB  . LEU   A 1 233 ? -6.300  -17.863 16.284  1.00 38.41  ? 328 LEU   A CB  1 
ATOM   1529 C  CG  . LEU   A 1 233 ? -5.708  -19.172 16.802  1.00 39.81  ? 328 LEU   A CG  1 
ATOM   1530 C  CD1 . LEU   A 1 233 ? -6.245  -20.374 16.023  1.00 37.61  ? 328 LEU   A CD1 1 
ATOM   1531 C  CD2 . LEU   A 1 233 ? -4.196  -19.109 16.741  1.00 36.45  ? 328 LEU   A CD2 1 
ATOM   1532 N  N   . SER   A 1 234 ? -9.147  -19.238 17.765  1.00 48.85  ? 329 SER   A N   1 
ATOM   1533 C  CA  . SER   A 1 234 ? -9.729  -19.835 18.964  1.00 43.03  ? 329 SER   A CA  1 
ATOM   1534 C  C   . SER   A 1 234 ? -9.289  -21.298 19.053  1.00 35.51  ? 329 SER   A C   1 
ATOM   1535 O  O   . SER   A 1 234 ? -8.736  -21.854 18.103  1.00 34.70  ? 329 SER   A O   1 
ATOM   1536 C  CB  . SER   A 1 234 ? -11.264 -19.700 18.932  1.00 36.79  ? 329 SER   A CB  1 
ATOM   1537 O  OG  . SER   A 1 234 ? -11.892 -20.324 20.037  1.00 52.35  ? 329 SER   A OG  1 
ATOM   1538 N  N   . TRP   A 1 235 ? -9.530  -21.931 20.207  1.00 41.14  ? 330 TRP   A N   1 
ATOM   1539 C  CA  . TRP   A 1 235 ? -9.122  -23.318 20.441  1.00 35.58  ? 330 TRP   A CA  1 
ATOM   1540 C  C   . TRP   A 1 235 ? -10.279 -24.112 21.028  1.00 41.48  ? 330 TRP   A C   1 
ATOM   1541 O  O   . TRP   A 1 235 ? -10.876 -23.699 22.025  1.00 43.35  ? 330 TRP   A O   1 
ATOM   1542 C  CB  . TRP   A 1 235 ? -7.903  -23.390 21.373  1.00 31.33  ? 330 TRP   A CB  1 
ATOM   1543 C  CG  . TRP   A 1 235 ? -6.686  -22.789 20.748  1.00 31.90  ? 330 TRP   A CG  1 
ATOM   1544 C  CD1 . TRP   A 1 235 ? -6.228  -21.517 20.910  1.00 29.60  ? 330 TRP   A CD1 1 
ATOM   1545 C  CD2 . TRP   A 1 235 ? -5.788  -23.425 19.827  1.00 36.46  ? 330 TRP   A CD2 1 
ATOM   1546 N  NE1 . TRP   A 1 235 ? -5.099  -21.316 20.153  1.00 37.65  ? 330 TRP   A NE1 1 
ATOM   1547 C  CE2 . TRP   A 1 235 ? -4.805  -22.473 19.480  1.00 33.61  ? 330 TRP   A CE2 1 
ATOM   1548 C  CE3 . TRP   A 1 235 ? -5.718  -24.706 19.265  1.00 35.52  ? 330 TRP   A CE3 1 
ATOM   1549 C  CZ2 . TRP   A 1 235 ? -3.764  -22.760 18.601  1.00 35.71  ? 330 TRP   A CZ2 1 
ATOM   1550 C  CZ3 . TRP   A 1 235 ? -4.686  -24.993 18.391  1.00 33.29  ? 330 TRP   A CZ3 1 
ATOM   1551 C  CH2 . TRP   A 1 235 ? -3.721  -24.025 18.068  1.00 45.78  ? 330 TRP   A CH2 1 
ATOM   1552 N  N   . SER   A 1 236 ? -10.586 -25.257 20.420  1.00 46.21  ? 331 SER   A N   1 
ATOM   1553 C  CA  . SER   A 1 236 ? -11.667 -26.097 20.912  1.00 44.03  ? 331 SER   A CA  1 
ATOM   1554 C  C   . SER   A 1 236 ? -11.236 -26.849 22.168  1.00 43.65  ? 331 SER   A C   1 
ATOM   1555 O  O   . SER   A 1 236 ? -10.092 -26.760 22.622  1.00 41.57  ? 331 SER   A O   1 
ATOM   1556 C  CB  . SER   A 1 236 ? -12.105 -27.085 19.841  1.00 40.43  ? 331 SER   A CB  1 
ATOM   1557 O  OG  . SER   A 1 236 ? -11.036 -27.961 19.543  1.00 49.46  ? 331 SER   A OG  1 
ATOM   1558 N  N   . SER   A 1 237 ? -12.172 -27.623 22.726  1.00 47.95  ? 332 SER   A N   1 
ATOM   1559 C  CA  . SER   A 1 237 ? -11.908 -28.375 23.949  1.00 45.16  ? 332 SER   A CA  1 
ATOM   1560 C  C   . SER   A 1 237 ? -10.900 -29.498 23.734  1.00 51.14  ? 332 SER   A C   1 
ATOM   1561 O  O   . SER   A 1 237 ? -10.337 -30.006 24.712  1.00 45.07  ? 332 SER   A O   1 
ATOM   1562 C  CB  . SER   A 1 237 ? -13.216 -28.943 24.504  1.00 30.26  ? 332 SER   A CB  1 
ATOM   1563 N  N   . HIS   A 1 238 ? -10.662 -29.892 22.481  1.00 51.80  ? 333 HIS   A N   1 
ATOM   1564 C  CA  . HIS   A 1 238 ? -9.735  -30.963 22.137  1.00 47.98  ? 333 HIS   A CA  1 
ATOM   1565 C  C   . HIS   A 1 238 ? -8.465  -30.441 21.481  1.00 52.14  ? 333 HIS   A C   1 
ATOM   1566 O  O   . HIS   A 1 238 ? -7.711  -31.220 20.888  1.00 51.21  ? 333 HIS   A O   1 
ATOM   1567 C  CB  . HIS   A 1 238 ? -10.424 -31.978 21.228  1.00 55.63  ? 333 HIS   A CB  1 
ATOM   1568 C  CG  . HIS   A 1 238 ? -11.330 -32.910 21.965  1.00 68.54  ? 333 HIS   A CG  1 
ATOM   1569 N  ND1 . HIS   A 1 238 ? -12.358 -33.597 21.356  1.00 73.51  ? 333 HIS   A ND1 1 
ATOM   1570 C  CD2 . HIS   A 1 238 ? -11.365 -33.260 23.273  1.00 69.94  ? 333 HIS   A CD2 1 
ATOM   1571 C  CE1 . HIS   A 1 238 ? -12.982 -34.337 22.256  1.00 76.99  ? 333 HIS   A CE1 1 
ATOM   1572 N  NE2 . HIS   A 1 238 ? -12.398 -34.150 23.427  1.00 82.32  ? 333 HIS   A NE2 1 
ATOM   1573 N  N   . GLY   A 1 239 ? -8.217  -29.135 21.575  1.00 55.66  ? 334 GLY   A N   1 
ATOM   1574 C  CA  . GLY   A 1 239 ? -7.000  -28.536 21.070  1.00 38.40  ? 334 GLY   A CA  1 
ATOM   1575 C  C   . GLY   A 1 239 ? -6.981  -28.233 19.592  1.00 35.53  ? 334 GLY   A C   1 
ATOM   1576 O  O   . GLY   A 1 239 ? -5.911  -27.939 19.054  1.00 37.62  ? 334 GLY   A O   1 
ATOM   1577 N  N   . THR   A 1 240 ? -8.107  -28.297 18.920  1.00 51.79  ? 335 THR   A N   1 
ATOM   1578 C  CA  . THR   A 1 240 ? -8.094  -28.002 17.491  1.00 50.38  ? 335 THR   A CA  1 
ATOM   1579 C  C   . THR   A 1 240 ? -8.316  -26.509 17.265  1.00 42.57  ? 335 THR   A C   1 
ATOM   1580 O  O   . THR   A 1 240 ? -9.162  -25.902 17.941  1.00 39.64  ? 335 THR   A O   1 
ATOM   1581 C  CB  . THR   A 1 240 ? -9.163  -28.804 16.765  1.00 47.68  ? 335 THR   A CB  1 
ATOM   1582 O  OG1 . THR   A 1 240 ? -9.280  -30.090 17.385  1.00 59.58  ? 335 THR   A OG1 1 
ATOM   1583 C  CG2 . THR   A 1 240 ? -8.803  -28.990 15.296  1.00 51.40  ? 335 THR   A CG2 1 
ATOM   1584 N  N   . PRO   A 1 241 ? -7.575  -25.890 16.352  1.00 39.39  ? 336 PRO   A N   1 
ATOM   1585 C  CA  . PRO   A 1 241 ? -7.718  -24.444 16.146  1.00 43.02  ? 336 PRO   A CA  1 
ATOM   1586 C  C   . PRO   A 1 241 ? -8.972  -24.104 15.353  1.00 47.66  ? 336 PRO   A C   1 
ATOM   1587 O  O   . PRO   A 1 241 ? -9.313  -24.768 14.370  1.00 53.65  ? 336 PRO   A O   1 
ATOM   1588 C  CB  . PRO   A 1 241 ? -6.448  -24.070 15.375  1.00 47.01  ? 336 PRO   A CB  1 
ATOM   1589 C  CG  . PRO   A 1 241 ? -6.057  -25.326 14.674  1.00 49.54  ? 336 PRO   A CG  1 
ATOM   1590 C  CD  . PRO   A 1 241 ? -6.445  -26.453 15.594  1.00 48.22  ? 336 PRO   A CD  1 
ATOM   1591 N  N   . LEU   A 1 242 ? -9.659  -23.053 15.797  1.00 42.67  ? 337 LEU   A N   1 
ATOM   1592 C  CA  . LEU   A 1 242 ? -10.887 -22.582 15.178  1.00 41.84  ? 337 LEU   A CA  1 
ATOM   1593 C  C   . LEU   A 1 242 ? -10.725 -21.131 14.740  1.00 42.21  ? 337 LEU   A C   1 
ATOM   1594 O  O   . LEU   A 1 242 ? -10.002 -20.352 15.371  1.00 36.19  ? 337 LEU   A O   1 
ATOM   1595 C  CB  . LEU   A 1 242 ? -12.071 -22.712 16.142  1.00 38.24  ? 337 LEU   A CB  1 
ATOM   1596 C  CG  . LEU   A 1 242 ? -12.198 -24.047 16.880  1.00 44.49  ? 337 LEU   A CG  1 
ATOM   1597 C  CD1 . LEU   A 1 242 ? -13.415 -24.030 17.771  1.00 38.17  ? 337 LEU   A CD1 1 
ATOM   1598 C  CD2 . LEU   A 1 242 ? -12.242 -25.225 15.920  1.00 40.97  ? 337 LEU   A CD2 1 
ATOM   1599 N  N   . LYS   A 1 243 ? -11.393 -20.776 13.642  1.00 36.37  ? 338 LYS   A N   1 
ATOM   1600 C  CA  . LYS   A 1 243 ? -11.335 -19.431 13.083  1.00 35.56  ? 338 LYS   A CA  1 
ATOM   1601 C  C   . LYS   A 1 243 ? -12.697 -18.752 13.162  1.00 43.31  ? 338 LYS   A C   1 
ATOM   1602 O  O   . LYS   A 1 243 ? -13.715 -19.328 12.764  1.00 43.42  ? 338 LYS   A O   1 
ATOM   1603 C  CB  . LYS   A 1 243 ? -10.875 -19.446 11.632  1.00 28.68  ? 338 LYS   A CB  1 
ATOM   1604 C  CG  . LYS   A 1 243 ? -10.786 -18.042 11.033  1.00 41.19  ? 338 LYS   A CG  1 
ATOM   1605 C  CD  . LYS   A 1 243 ? -10.324 -18.052 9.588   1.00 39.87  ? 338 LYS   A CD  1 
ATOM   1606 C  CE  . LYS   A 1 243 ? -10.371 -16.656 9.005   1.00 37.11  ? 338 LYS   A CE  1 
ATOM   1607 N  NZ  . LYS   A 1 243 ? -9.934  -16.630 7.582   1.00 33.44  ? 338 LYS   A NZ  1 
ATOM   1608 N  N   . ARG   A 1 244 ? -12.712 -17.521 13.669  1.00 42.14  ? 339 ARG   A N   1 
ATOM   1609 C  CA  . ARG   A 1 244 ? -13.914 -16.694 13.677  1.00 42.32  ? 339 ARG   A CA  1 
ATOM   1610 C  C   . ARG   A 1 244 ? -13.896 -15.836 12.418  1.00 35.93  ? 339 ARG   A C   1 
ATOM   1611 O  O   . ARG   A 1 244 ? -12.987 -15.023 12.225  1.00 39.58  ? 339 ARG   A O   1 
ATOM   1612 C  CB  . ARG   A 1 244 ? -13.992 -15.837 14.939  1.00 42.32  ? 339 ARG   A CB  1 
ATOM   1613 C  CG  . ARG   A 1 244 ? -14.439 -16.603 16.186  1.00 53.89  ? 339 ARG   A CG  1 
ATOM   1614 C  CD  . ARG   A 1 244 ? -14.977 -15.661 17.251  1.00 55.87  ? 339 ARG   A CD  1 
ATOM   1615 N  NE  . ARG   A 1 244 ? -16.150 -14.918 16.794  1.00 55.09  ? 339 ARG   A NE  1 
ATOM   1616 C  CZ  . ARG   A 1 244 ? -16.797 -14.016 17.529  1.00 50.79  ? 339 ARG   A CZ  1 
ATOM   1617 N  NH1 . ARG   A 1 244 ? -16.375 -13.731 18.755  1.00 45.03  ? 339 ARG   A NH1 1 
ATOM   1618 N  NH2 . ARG   A 1 244 ? -17.860 -13.392 17.035  1.00 51.38  ? 339 ARG   A NH2 1 
ATOM   1619 N  N   . HIS   A 1 245 ? -14.892 -16.034 11.559  1.00 39.08  ? 340 HIS   A N   1 
ATOM   1620 C  CA  . HIS   A 1 245 ? -15.017 -15.306 10.304  1.00 44.77  ? 340 HIS   A CA  1 
ATOM   1621 C  C   . HIS   A 1 245 ? -15.945 -14.097 10.410  1.00 38.93  ? 340 HIS   A C   1 
ATOM   1622 O  O   . HIS   A 1 245 ? -16.198 -13.435 9.396   1.00 41.64  ? 340 HIS   A O   1 
ATOM   1623 C  CB  . HIS   A 1 245 ? -15.511 -16.240 9.186   1.00 40.48  ? 340 HIS   A CB  1 
ATOM   1624 C  CG  . HIS   A 1 245 ? -14.786 -17.552 9.102   1.00 41.01  ? 340 HIS   A CG  1 
ATOM   1625 N  ND1 . HIS   A 1 245 ? -14.956 -18.564 10.025  1.00 51.37  ? 340 HIS   A ND1 1 
ATOM   1626 C  CD2 . HIS   A 1 245 ? -13.897 -18.020 8.193   1.00 37.83  ? 340 HIS   A CD2 1 
ATOM   1627 C  CE1 . HIS   A 1 245 ? -14.199 -19.595 9.690   1.00 53.43  ? 340 HIS   A CE1 1 
ATOM   1628 N  NE2 . HIS   A 1 245 ? -13.548 -19.291 8.581   1.00 46.74  ? 340 HIS   A NE2 1 
ATOM   1629 N  N   . GLU   A 1 246 ? -16.450 -13.792 11.604  1.00 29.11  ? 341 GLU   A N   1 
ATOM   1630 C  CA  . GLU   A 1 246 ? -17.393 -12.694 11.759  1.00 31.81  ? 341 GLU   A CA  1 
ATOM   1631 C  C   . GLU   A 1 246 ? -16.784 -11.384 11.271  1.00 37.51  ? 341 GLU   A C   1 
ATOM   1632 O  O   . GLU   A 1 246 ? -15.591 -11.122 11.458  1.00 35.61  ? 341 GLU   A O   1 
ATOM   1633 C  CB  . GLU   A 1 246 ? -17.831 -12.559 13.221  1.00 36.61  ? 341 GLU   A CB  1 
ATOM   1634 N  N   . HIS   A 1 247 ? -17.617 -10.568 10.627  1.00 37.81  ? 342 HIS   A N   1 
ATOM   1635 C  CA  . HIS   A 1 247 ? -17.201 -9.261  10.142  1.00 30.90  ? 342 HIS   A CA  1 
ATOM   1636 C  C   . HIS   A 1 247 ? -17.167 -8.264  11.290  1.00 31.24  ? 342 HIS   A C   1 
ATOM   1637 O  O   . HIS   A 1 247 ? -18.062 -8.239  12.138  1.00 44.11  ? 342 HIS   A O   1 
ATOM   1638 C  CB  . HIS   A 1 247 ? -18.157 -8.770  9.053   1.00 23.40  ? 342 HIS   A CB  1 
ATOM   1639 C  CG  . HIS   A 1 247 ? -17.767 -7.457  8.442   1.00 32.98  ? 342 HIS   A CG  1 
ATOM   1640 N  ND1 . HIS   A 1 247 ? -18.201 -6.244  8.935   1.00 39.17  ? 342 HIS   A ND1 1 
ATOM   1641 C  CD2 . HIS   A 1 247 ? -16.986 -7.170  7.373   1.00 31.35  ? 342 HIS   A CD2 1 
ATOM   1642 C  CE1 . HIS   A 1 247 ? -17.701 -5.267  8.197   1.00 30.04  ? 342 HIS   A CE1 1 
ATOM   1643 N  NE2 . HIS   A 1 247 ? -16.959 -5.802  7.244   1.00 24.85  ? 342 HIS   A NE2 1 
ATOM   1644 N  N   . VAL   A 1 248 ? -16.123 -7.448  11.326  1.00 24.68  ? 343 VAL   A N   1 
ATOM   1645 C  CA  . VAL   A 1 248 ? -16.024 -6.357  12.286  1.00 39.63  ? 343 VAL   A CA  1 
ATOM   1646 C  C   . VAL   A 1 248 ? -16.040 -5.052  11.503  1.00 39.13  ? 343 VAL   A C   1 
ATOM   1647 O  O   . VAL   A 1 248 ? -15.199 -4.837  10.619  1.00 34.84  ? 343 VAL   A O   1 
ATOM   1648 C  CB  . VAL   A 1 248 ? -14.766 -6.470  13.160  1.00 34.30  ? 343 VAL   A CB  1 
ATOM   1649 C  CG1 . VAL   A 1 248 ? -14.682 -5.295  14.108  1.00 28.11  ? 343 VAL   A CG1 1 
ATOM   1650 C  CG2 . VAL   A 1 248 ? -14.779 -7.779  13.935  1.00 43.19  ? 343 VAL   A CG2 1 
ATOM   1651 N  N   . GLN   A 1 249 ? -17.007 -4.192  11.811  1.00 35.30  ? 344 GLN   A N   1 
ATOM   1652 C  CA  . GLN   A 1 249 ? -17.103 -2.905  11.139  1.00 34.78  ? 344 GLN   A CA  1 
ATOM   1653 C  C   . GLN   A 1 249 ? -15.964 -1.991  11.588  1.00 36.33  ? 344 GLN   A C   1 
ATOM   1654 O  O   . GLN   A 1 249 ? -15.681 -1.874  12.785  1.00 30.82  ? 344 GLN   A O   1 
ATOM   1655 C  CB  . GLN   A 1 249 ? -18.457 -2.256  11.429  1.00 36.40  ? 344 GLN   A CB  1 
ATOM   1656 N  N   . PHE   A 1 250 ? -15.305 -1.352  10.621  1.00 31.06  ? 345 PHE   A N   1 
ATOM   1657 C  CA  . PHE   A 1 250 ? -14.269 -0.363  10.891  1.00 31.69  ? 345 PHE   A CA  1 
ATOM   1658 C  C   . PHE   A 1 250 ? -14.343 0.722   9.822   1.00 31.33  ? 345 PHE   A C   1 
ATOM   1659 O  O   . PHE   A 1 250 ? -14.977 0.546   8.779   1.00 36.32  ? 345 PHE   A O   1 
ATOM   1660 C  CB  . PHE   A 1 250 ? -12.870 -1.004  10.934  1.00 39.92  ? 345 PHE   A CB  1 
ATOM   1661 C  CG  . PHE   A 1 250 ? -12.442 -1.642  9.631   1.00 37.88  ? 345 PHE   A CG  1 
ATOM   1662 C  CD1 . PHE   A 1 250 ? -12.826 -2.937  9.321   1.00 24.01  ? 345 PHE   A CD1 1 
ATOM   1663 C  CD2 . PHE   A 1 250 ? -11.657 -0.942  8.721   1.00 27.69  ? 345 PHE   A CD2 1 
ATOM   1664 C  CE1 . PHE   A 1 250 ? -12.443 -3.520  8.134   1.00 25.76  ? 345 PHE   A CE1 1 
ATOM   1665 C  CE2 . PHE   A 1 250 ? -11.266 -1.526  7.533   1.00 27.82  ? 345 PHE   A CE2 1 
ATOM   1666 C  CZ  . PHE   A 1 250 ? -11.659 -2.815  7.239   1.00 28.56  ? 345 PHE   A CZ  1 
ATOM   1667 N  N   . ASN   A 1 251 ? -13.697 1.852   10.088  1.00 31.28  ? 346 ASN   A N   1 
ATOM   1668 C  CA  . ASN   A 1 251 ? -13.691 2.979   9.164   1.00 37.60  ? 346 ASN   A CA  1 
ATOM   1669 C  C   . ASN   A 1 251 ? -12.256 3.372   8.825   1.00 39.51  ? 346 ASN   A C   1 
ATOM   1670 O  O   . ASN   A 1 251 ? -11.299 2.949   9.479   1.00 43.16  ? 346 ASN   A O   1 
ATOM   1671 C  CB  . ASN   A 1 251 ? -14.453 4.179   9.748   1.00 31.02  ? 346 ASN   A CB  1 
ATOM   1672 C  CG  . ASN   A 1 251 ? -15.838 3.803   10.256  1.00 44.07  ? 346 ASN   A CG  1 
ATOM   1673 O  OD1 . ASN   A 1 251 ? -16.774 3.623   9.471   1.00 51.27  ? 346 ASN   A OD1 1 
ATOM   1674 N  ND2 . ASN   A 1 251 ? -15.979 3.696   11.573  1.00 49.25  ? 346 ASN   A ND2 1 
ATOM   1675 N  N   . GLU   A 1 252 ? -12.111 4.202   7.787   1.00 32.56  ? 347 GLU   A N   1 
ATOM   1676 C  CA  . GLU   A 1 252 ? -10.786 4.691   7.429   1.00 37.10  ? 347 GLU   A CA  1 
ATOM   1677 C  C   . GLU   A 1 252 ? -10.249 5.688   8.443   1.00 32.86  ? 347 GLU   A C   1 
ATOM   1678 O  O   . GLU   A 1 252 ? -9.041  5.933   8.467   1.00 43.70  ? 347 GLU   A O   1 
ATOM   1679 C  CB  . GLU   A 1 252 ? -10.799 5.323   6.036   1.00 40.03  ? 347 GLU   A CB  1 
ATOM   1680 C  CG  . GLU   A 1 252 ? -11.330 6.742   5.992   1.00 52.21  ? 347 GLU   A CG  1 
ATOM   1681 C  CD  . GLU   A 1 252 ? -11.104 7.414   4.639   1.00 59.13  ? 347 GLU   A CD  1 
ATOM   1682 O  OE1 . GLU   A 1 252 ? -10.100 7.080   3.963   1.00 59.19  ? 347 GLU   A OE1 1 
ATOM   1683 O  OE2 . GLU   A 1 252 ? -11.941 8.265   4.250   1.00 42.46  ? 347 GLU   A OE2 1 
ATOM   1684 N  N   . ASP   A 1 253 ? -11.106 6.257   9.283   1.00 33.62  ? 348 ASP   A N   1 
ATOM   1685 C  CA  . ASP   A 1 253 ? -10.696 7.207   10.307  1.00 37.97  ? 348 ASP   A CA  1 
ATOM   1686 C  C   . ASP   A 1 253 ? -11.104 6.654   11.664  1.00 36.02  ? 348 ASP   A C   1 
ATOM   1687 O  O   . ASP   A 1 253 ? -12.236 6.198   11.833  1.00 37.89  ? 348 ASP   A O   1 
ATOM   1688 C  CB  . ASP   A 1 253 ? -11.321 8.590   10.069  1.00 41.84  ? 348 ASP   A CB  1 
ATOM   1689 C  CG  . ASP   A 1 253 ? -10.660 9.352   8.903   1.00 57.03  ? 348 ASP   A CG  1 
ATOM   1690 O  OD1 . ASP   A 1 253 ? -9.437  9.191   8.692   1.00 47.03  ? 348 ASP   A OD1 1 
ATOM   1691 O  OD2 . ASP   A 1 253 ? -11.363 10.128  8.210   1.00 57.35  ? 348 ASP   A OD2 1 
ATOM   1692 N  N   . LEU   A 1 254 ? -10.180 6.664   12.618  1.00 38.34  ? 349 LEU   A N   1 
ATOM   1693 C  CA  . LEU   A 1 254 ? -10.425 6.079   13.930  1.00 33.98  ? 349 LEU   A CA  1 
ATOM   1694 C  C   . LEU   A 1 254 ? -9.940  7.059   14.987  1.00 41.21  ? 349 LEU   A C   1 
ATOM   1695 O  O   . LEU   A 1 254 ? -8.769  7.456   14.979  1.00 40.48  ? 349 LEU   A O   1 
ATOM   1696 C  CB  . LEU   A 1 254 ? -9.724  4.720   14.071  1.00 34.65  ? 349 LEU   A CB  1 
ATOM   1697 C  CG  . LEU   A 1 254 ? -9.651  4.068   15.461  1.00 40.39  ? 349 LEU   A CG  1 
ATOM   1698 C  CD1 . LEU   A 1 254 ? -11.009 3.539   15.943  1.00 32.71  ? 349 LEU   A CD1 1 
ATOM   1699 C  CD2 . LEU   A 1 254 ? -8.584  2.961   15.487  1.00 33.38  ? 349 LEU   A CD2 1 
ATOM   1700 N  N   . SER   A 1 255 ? -10.840 7.467   15.876  1.00 38.44  ? 350 SER   A N   1 
ATOM   1701 C  CA  . SER   A 1 255 ? -10.491 8.367   16.965  1.00 42.49  ? 350 SER   A CA  1 
ATOM   1702 C  C   . SER   A 1 255 ? -10.219 7.542   18.213  1.00 49.22  ? 350 SER   A C   1 
ATOM   1703 O  O   . SER   A 1 255 ? -10.956 6.599   18.515  1.00 53.61  ? 350 SER   A O   1 
ATOM   1704 C  CB  . SER   A 1 255 ? -11.603 9.383   17.227  1.00 26.26  ? 350 SER   A CB  1 
ATOM   1705 N  N   . MET   A 1 256 ? -9.154  7.887   18.927  1.00 57.81  ? 351 MET   A N   1 
ATOM   1706 C  CA  . MET   A 1 256 ? -8.799  7.197   20.159  1.00 57.38  ? 351 MET   A CA  1 
ATOM   1707 C  C   . MET   A 1 256 ? -8.937  8.113   21.375  1.00 68.00  ? 351 MET   A C   1 
ATOM   1708 O  O   . MET   A 1 256 ? -8.275  7.909   22.395  1.00 70.03  ? 351 MET   A O   1 
ATOM   1709 C  CB  . MET   A 1 256 ? -7.384  6.631   20.049  1.00 50.24  ? 351 MET   A CB  1 
ATOM   1710 C  CG  . MET   A 1 256 ? -7.240  5.526   18.998  1.00 43.54  ? 351 MET   A CG  1 
ATOM   1711 S  SD  . MET   A 1 256 ? -7.710  3.902   19.635  1.00 47.64  ? 351 MET   A SD  1 
ATOM   1712 C  CE  . MET   A 1 256 ? -6.412  3.652   20.853  1.00 54.15  ? 351 MET   A CE  1 
ATOM   1713 N  N   . ASP   A 1 257 ? -9.804  9.128   21.275  1.00 67.03  ? 352 ASP   A N   1 
ATOM   1714 C  CA  . ASP   A 1 257 ? -9.967  10.099  22.352  1.00 65.32  ? 352 ASP   A CA  1 
ATOM   1715 C  C   . ASP   A 1 257 ? -10.756 9.534   23.524  1.00 65.72  ? 352 ASP   A C   1 
ATOM   1716 O  O   . ASP   A 1 257 ? -10.500 9.909   24.675  1.00 78.72  ? 352 ASP   A O   1 
ATOM   1717 C  CB  . ASP   A 1 257 ? -10.650 11.362  21.820  1.00 62.31  ? 352 ASP   A CB  1 
ATOM   1718 C  CG  . ASP   A 1 257 ? -9.762  12.151  20.875  1.00 73.20  ? 352 ASP   A CG  1 
ATOM   1719 O  OD1 . ASP   A 1 257 ? -9.143  11.530  19.987  1.00 70.57  ? 352 ASP   A OD1 1 
ATOM   1720 O  OD2 . ASP   A 1 257 ? -9.681  13.392  21.020  1.00 78.70  ? 352 ASP   A OD2 1 
ATOM   1721 N  N   . GLU   A 1 258 ? -11.706 8.640   23.257  1.00 69.94  ? 353 GLU   A N   1 
ATOM   1722 C  CA  . GLU   A 1 258 ? -12.503 8.014   24.303  1.00 70.91  ? 353 GLU   A CA  1 
ATOM   1723 C  C   . GLU   A 1 258 ? -11.732 6.964   25.099  1.00 69.48  ? 353 GLU   A C   1 
ATOM   1724 O  O   . GLU   A 1 258 ? -12.269 6.442   26.081  1.00 64.97  ? 353 GLU   A O   1 
ATOM   1725 C  CB  . GLU   A 1 258 ? -13.757 7.382   23.691  1.00 57.50  ? 353 GLU   A CB  1 
ATOM   1726 N  N   . TYR   A 1 259 ? -10.498 6.641   24.706  1.00 70.94  ? 354 TYR   A N   1 
ATOM   1727 C  CA  . TYR   A 1 259 ? -9.702  5.636   25.394  1.00 66.34  ? 354 TYR   A CA  1 
ATOM   1728 C  C   . TYR   A 1 259 ? -8.440  6.204   26.024  1.00 70.97  ? 354 TYR   A C   1 
ATOM   1729 O  O   . TYR   A 1 259 ? -7.632  5.434   26.561  1.00 66.08  ? 354 TYR   A O   1 
ATOM   1730 C  CB  . TYR   A 1 259 ? -9.329  4.501   24.429  1.00 68.85  ? 354 TYR   A CB  1 
ATOM   1731 C  CG  . TYR   A 1 259 ? -10.491 4.036   23.572  1.00 70.08  ? 354 TYR   A CG  1 
ATOM   1732 C  CD1 . TYR   A 1 259 ? -11.426 3.135   24.064  1.00 65.88  ? 354 TYR   A CD1 1 
ATOM   1733 C  CD2 . TYR   A 1 259 ? -10.656 4.503   22.274  1.00 66.98  ? 354 TYR   A CD2 1 
ATOM   1734 C  CE1 . TYR   A 1 259 ? -12.488 2.710   23.290  1.00 57.67  ? 354 TYR   A CE1 1 
ATOM   1735 C  CE2 . TYR   A 1 259 ? -11.717 4.082   21.493  1.00 58.18  ? 354 TYR   A CE2 1 
ATOM   1736 C  CZ  . TYR   A 1 259 ? -12.629 3.186   22.009  1.00 59.34  ? 354 TYR   A CZ  1 
ATOM   1737 O  OH  . TYR   A 1 259 ? -13.692 2.758   21.244  1.00 69.30  ? 354 TYR   A OH  1 
ATOM   1738 N  N   . LYS   A 1 260 ? -8.253  7.521   25.982  1.00 67.33  ? 355 LYS   A N   1 
ATOM   1739 C  CA  . LYS   A 1 260 ? -7.085  8.163   26.578  1.00 77.30  ? 355 LYS   A CA  1 
ATOM   1740 C  C   . LYS   A 1 260 ? -7.319  8.479   28.051  1.00 78.08  ? 355 LYS   A C   1 
ATOM   1741 O  O   . LYS   A 1 260 ? -6.873  7.737   28.927  1.00 78.16  ? 355 LYS   A O   1 
ATOM   1742 C  CB  . LYS   A 1 260 ? -6.728  9.444   25.820  1.00 73.59  ? 355 LYS   A CB  1 
ATOM   1743 C  CG  . LYS   A 1 260 ? -5.501  9.311   24.941  1.00 57.84  ? 355 LYS   A CG  1 
ATOM   1744 C  CD  . LYS   A 1 260 ? -4.277  8.949   25.764  1.00 49.49  ? 355 LYS   A CD  1 
ATOM   1745 N  N   . LEU   A 1 269 ? -6.782  10.902  16.621  1.00 23.10  ? 435 LEU   A N   1 
ATOM   1746 C  CA  . LEU   A 1 269 ? -7.229  10.672  15.238  1.00 35.65  ? 435 LEU   A CA  1 
ATOM   1747 C  C   . LEU   A 1 269 ? -6.221  9.923   14.352  1.00 37.80  ? 435 LEU   A C   1 
ATOM   1748 O  O   . LEU   A 1 269 ? -5.129  10.422  14.058  1.00 33.20  ? 435 LEU   A O   1 
ATOM   1749 C  CB  . LEU   A 1 269 ? -7.572  11.994  14.560  1.00 23.58  ? 435 LEU   A CB  1 
ATOM   1750 C  CG  . LEU   A 1 269 ? -8.342  11.942  13.229  1.00 37.94  ? 435 LEU   A CG  1 
ATOM   1751 C  CD1 . LEU   A 1 269 ? -9.425  10.858  13.178  1.00 33.51  ? 435 LEU   A CD1 1 
ATOM   1752 C  CD2 . LEU   A 1 269 ? -8.945  13.300  12.924  1.00 61.97  ? 435 LEU   A CD2 1 
ATOM   1753 N  N   . PHE   A 1 270 ? -6.629  8.739   13.896  1.00 32.62  ? 436 PHE   A N   1 
ATOM   1754 C  CA  . PHE   A 1 270 ? -5.789  7.845   13.113  1.00 28.70  ? 436 PHE   A CA  1 
ATOM   1755 C  C   . PHE   A 1 270 ? -6.443  7.550   11.765  1.00 34.20  ? 436 PHE   A C   1 
ATOM   1756 O  O   . PHE   A 1 270 ? -7.667  7.389   11.670  1.00 33.33  ? 436 PHE   A O   1 
ATOM   1757 C  CB  . PHE   A 1 270 ? -5.524  6.544   13.887  1.00 24.87  ? 436 PHE   A CB  1 
ATOM   1758 C  CG  . PHE   A 1 270 ? -4.628  6.722   15.075  1.00 27.82  ? 436 PHE   A CG  1 
ATOM   1759 C  CD1 . PHE   A 1 270 ? -5.123  7.225   16.268  1.00 30.55  ? 436 PHE   A CD1 1 
ATOM   1760 C  CD2 . PHE   A 1 270 ? -3.287  6.388   15.003  1.00 31.72  ? 436 PHE   A CD2 1 
ATOM   1761 C  CE1 . PHE   A 1 270 ? -4.294  7.404   17.368  1.00 26.41  ? 436 PHE   A CE1 1 
ATOM   1762 C  CE2 . PHE   A 1 270 ? -2.451  6.557   16.099  1.00 35.03  ? 436 PHE   A CE2 1 
ATOM   1763 C  CZ  . PHE   A 1 270 ? -2.958  7.062   17.288  1.00 32.02  ? 436 PHE   A CZ  1 
ATOM   1764 N  N   . ARG   A 1 271 ? -5.615  7.486   10.728  1.00 32.22  ? 437 ARG   A N   1 
ATOM   1765 C  CA  . ARG   A 1 271 ? -6.034  7.200   9.363   1.00 30.93  ? 437 ARG   A CA  1 
ATOM   1766 C  C   . ARG   A 1 271 ? -5.633  5.774   9.000   1.00 34.48  ? 437 ARG   A C   1 
ATOM   1767 O  O   . ARG   A 1 271 ? -4.477  5.386   9.204   1.00 37.09  ? 437 ARG   A O   1 
ATOM   1768 C  CB  . ARG   A 1 271 ? -5.385  8.193   8.397   1.00 35.95  ? 437 ARG   A CB  1 
ATOM   1769 C  CG  . ARG   A 1 271 ? -5.933  8.175   6.988   1.00 39.86  ? 437 ARG   A CG  1 
ATOM   1770 C  CD  . ARG   A 1 271 ? -7.018  9.209   6.834   1.00 45.30  ? 437 ARG   A CD  1 
ATOM   1771 N  NE  . ARG   A 1 271 ? -6.492  10.560  6.647   1.00 53.89  ? 437 ARG   A NE  1 
ATOM   1772 C  CZ  . ARG   A 1 271 ? -7.095  11.656  7.102   1.00 55.23  ? 437 ARG   A CZ  1 
ATOM   1773 N  NH1 . ARG   A 1 271 ? -8.238  11.551  7.771   1.00 57.04  ? 437 ARG   A NH1 1 
ATOM   1774 N  NH2 . ARG   A 1 271 ? -6.561  12.853  6.893   1.00 56.60  ? 437 ARG   A NH2 1 
ATOM   1775 N  N   . LEU   A 1 272 ? -6.578  5.002   8.462   1.00 25.83  ? 438 LEU   A N   1 
ATOM   1776 C  CA  . LEU   A 1 272 ? -6.279  3.647   8.007   1.00 25.31  ? 438 LEU   A CA  1 
ATOM   1777 C  C   . LEU   A 1 272 ? -5.382  3.683   6.778   1.00 31.70  ? 438 LEU   A C   1 
ATOM   1778 O  O   . LEU   A 1 272 ? -5.695  4.354   5.791   1.00 30.66  ? 438 LEU   A O   1 
ATOM   1779 C  CB  . LEU   A 1 272 ? -7.567  2.898   7.678   1.00 31.96  ? 438 LEU   A CB  1 
ATOM   1780 C  CG  . LEU   A 1 272 ? -7.483  1.401   7.379   1.00 28.71  ? 438 LEU   A CG  1 
ATOM   1781 C  CD1 . LEU   A 1 272 ? -7.251  0.635   8.663   1.00 22.65  ? 438 LEU   A CD1 1 
ATOM   1782 C  CD2 . LEU   A 1 272 ? -8.759  0.928   6.716   1.00 31.43  ? 438 LEU   A CD2 1 
ATOM   1783 N  N   . MET   A 1 273 ? -4.264  2.959   6.842   1.00 32.24  ? 439 MET   A N   1 
ATOM   1784 C  CA  . MET   A 1 273 ? -3.305  2.876   5.747   1.00 26.82  ? 439 MET   A CA  1 
ATOM   1785 C  C   . MET   A 1 273 ? -3.306  1.529   5.044   1.00 29.07  ? 439 MET   A C   1 
ATOM   1786 O  O   . MET   A 1 273 ? -3.171  1.477   3.817   1.00 31.75  ? 439 MET   A O   1 
ATOM   1787 C  CB  . MET   A 1 273 ? -1.890  3.164   6.257   1.00 30.96  ? 439 MET   A CB  1 
ATOM   1788 C  CG  . MET   A 1 273 ? -1.711  4.530   6.892   1.00 38.78  ? 439 MET   A CG  1 
ATOM   1789 S  SD  . MET   A 1 273 ? -2.159  5.913   5.817   1.00 43.74  ? 439 MET   A SD  1 
ATOM   1790 C  CE  . MET   A 1 273 ? -1.038  5.689   4.439   1.00 40.42  ? 439 MET   A CE  1 
ATOM   1791 N  N   . ALA   A 1 274 ? -3.434  0.431   5.786   1.00 25.96  ? 440 ALA   A N   1 
ATOM   1792 C  CA  . ALA   A 1 274 ? -3.520  -0.884  5.171   1.00 25.43  ? 440 ALA   A CA  1 
ATOM   1793 C  C   . ALA   A 1 274 ? -4.287  -1.821  6.089   1.00 29.75  ? 440 ALA   A C   1 
ATOM   1794 O  O   . ALA   A 1 274 ? -4.496  -1.531  7.271   1.00 26.29  ? 440 ALA   A O   1 
ATOM   1795 C  CB  . ALA   A 1 274 ? -2.143  -1.460  4.854   1.00 24.55  ? 440 ALA   A CB  1 
ATOM   1796 N  N   . VAL   A 1 275 ? -4.727  -2.941  5.514   1.00 26.36  ? 441 VAL   A N   1 
ATOM   1797 C  CA  . VAL   A 1 275 ? -5.507  -3.959  6.212   1.00 28.28  ? 441 VAL   A CA  1 
ATOM   1798 C  C   . VAL   A 1 275 ? -5.036  -5.332  5.746   1.00 34.57  ? 441 VAL   A C   1 
ATOM   1799 O  O   . VAL   A 1 275 ? -5.067  -5.630  4.547   1.00 26.54  ? 441 VAL   A O   1 
ATOM   1800 C  CB  . VAL   A 1 275 ? -7.020  -3.816  5.945   1.00 34.07  ? 441 VAL   A CB  1 
ATOM   1801 C  CG1 . VAL   A 1 275 ? -7.781  -5.008  6.528   1.00 22.79  ? 441 VAL   A CG1 1 
ATOM   1802 C  CG2 . VAL   A 1 275 ? -7.554  -2.491  6.474   1.00 34.79  ? 441 VAL   A CG2 1 
ATOM   1803 N  N   . VAL   A 1 276 ? -4.609  -6.171  6.684   1.00 36.03  ? 442 VAL   A N   1 
ATOM   1804 C  CA  . VAL   A 1 276 ? -4.263  -7.555  6.385   1.00 28.42  ? 442 VAL   A CA  1 
ATOM   1805 C  C   . VAL   A 1 276 ? -5.510  -8.398  6.597   1.00 28.42  ? 442 VAL   A C   1 
ATOM   1806 O  O   . VAL   A 1 276 ? -6.117  -8.361  7.673   1.00 34.38  ? 442 VAL   A O   1 
ATOM   1807 C  CB  . VAL   A 1 276 ? -3.095  -8.053  7.251   1.00 36.02  ? 442 VAL   A CB  1 
ATOM   1808 C  CG1 . VAL   A 1 276 ? -2.824  -9.529  6.976   1.00 32.71  ? 442 VAL   A CG1 1 
ATOM   1809 C  CG2 . VAL   A 1 276 ? -1.838  -7.223  6.985   1.00 27.29  ? 442 VAL   A CG2 1 
ATOM   1810 N  N   . VAL   A 1 277 ? -5.892  -9.155  5.571   1.00 30.23  ? 443 VAL   A N   1 
ATOM   1811 C  CA  . VAL   A 1 277 ? -7.085  -9.994  5.584   1.00 31.27  ? 443 VAL   A CA  1 
ATOM   1812 C  C   . VAL   A 1 277 ? -6.659  -11.442 5.411   1.00 27.62  ? 443 VAL   A C   1 
ATOM   1813 O  O   . VAL   A 1 277 ? -5.821  -11.749 4.555   1.00 30.08  ? 443 VAL   A O   1 
ATOM   1814 C  CB  . VAL   A 1 277 ? -8.076  -9.595  4.474   1.00 33.17  ? 443 VAL   A CB  1 
ATOM   1815 C  CG1 . VAL   A 1 277 ? -9.256  -10.560 4.443   1.00 34.08  ? 443 VAL   A CG1 1 
ATOM   1816 C  CG2 . VAL   A 1 277 ? -8.552  -8.168  4.675   1.00 26.68  ? 443 VAL   A CG2 1 
ATOM   1817 N  N   . HIS   A 1 278 ? -7.241  -12.331 6.209   1.00 29.98  ? 444 HIS   A N   1 
ATOM   1818 C  CA  . HIS   A 1 278 ? -6.991  -13.758 6.093   1.00 31.12  ? 444 HIS   A CA  1 
ATOM   1819 C  C   . HIS   A 1 278 ? -8.252  -14.450 5.586   1.00 41.02  ? 444 HIS   A C   1 
ATOM   1820 O  O   . HIS   A 1 278 ? -9.321  -14.333 6.198   1.00 29.95  ? 444 HIS   A O   1 
ATOM   1821 C  CB  . HIS   A 1 278 ? -6.556  -14.358 7.427   1.00 28.31  ? 444 HIS   A CB  1 
ATOM   1822 C  CG  . HIS   A 1 278 ? -6.227  -15.816 7.336   1.00 39.86  ? 444 HIS   A CG  1 
ATOM   1823 N  ND1 . HIS   A 1 278 ? -7.155  -16.807 7.568   1.00 38.61  ? 444 HIS   A ND1 1 
ATOM   1824 C  CD2 . HIS   A 1 278 ? -5.078  -16.450 7.003   1.00 42.04  ? 444 HIS   A CD2 1 
ATOM   1825 C  CE1 . HIS   A 1 278 ? -6.590  -17.988 7.400   1.00 38.60  ? 444 HIS   A CE1 1 
ATOM   1826 N  NE2 . HIS   A 1 278 ? -5.328  -17.800 7.058   1.00 41.68  ? 444 HIS   A NE2 1 
ATOM   1827 N  N   . HIS   A 1 279 ? -8.122  -15.178 4.481   1.00 39.98  ? 445 HIS   A N   1 
ATOM   1828 C  CA  . HIS   A 1 279 ? -9.211  -15.953 3.901   1.00 45.22  ? 445 HIS   A CA  1 
ATOM   1829 C  C   . HIS   A 1 279 ? -9.027  -17.434 4.212   1.00 37.88  ? 445 HIS   A C   1 
ATOM   1830 O  O   . HIS   A 1 279 ? -7.978  -17.870 4.691   1.00 44.48  ? 445 HIS   A O   1 
ATOM   1831 C  CB  . HIS   A 1 279 ? -9.286  -15.724 2.387   1.00 41.02  ? 445 HIS   A CB  1 
ATOM   1832 C  CG  . HIS   A 1 279 ? -9.734  -14.348 2.014   1.00 48.23  ? 445 HIS   A CG  1 
ATOM   1833 N  ND1 . HIS   A 1 279 ? -9.252  -13.676 0.911   1.00 49.31  ? 445 HIS   A ND1 1 
ATOM   1834 C  CD2 . HIS   A 1 279 ? -10.622 -13.515 2.606   1.00 49.97  ? 445 HIS   A CD2 1 
ATOM   1835 C  CE1 . HIS   A 1 279 ? -9.829  -12.490 0.837   1.00 49.16  ? 445 HIS   A CE1 1 
ATOM   1836 N  NE2 . HIS   A 1 279 ? -10.665 -12.367 1.854   1.00 54.91  ? 445 HIS   A NE2 1 
ATOM   1837 N  N   . GLY   A 1 280 ? -10.074 -18.208 3.944   1.00 40.53  ? 446 GLY   A N   1 
ATOM   1838 C  CA  . GLY   A 1 280 ? -10.000 -19.643 4.158   1.00 46.23  ? 446 GLY   A CA  1 
ATOM   1839 C  C   . GLY   A 1 280 ? -9.996  -20.018 5.635   1.00 45.62  ? 446 GLY   A C   1 
ATOM   1840 O  O   . GLY   A 1 280 ? -10.386 -19.245 6.514   1.00 40.21  ? 446 GLY   A O   1 
ATOM   1841 N  N   . ASP   A 1 281 ? -9.544  -21.239 5.900   1.00 48.84  ? 447 ASP   A N   1 
ATOM   1842 C  CA  . ASP   A 1 281 ? -9.482  -21.753 7.257   1.00 41.70  ? 447 ASP   A CA  1 
ATOM   1843 C  C   . ASP   A 1 281 ? -8.047  -21.669 7.775   1.00 49.18  ? 447 ASP   A C   1 
ATOM   1844 O  O   . ASP   A 1 281 ? -7.153  -21.118 7.124   1.00 46.51  ? 447 ASP   A O   1 
ATOM   1845 C  CB  . ASP   A 1 281 ? -10.021 -23.182 7.305   1.00 41.87  ? 447 ASP   A CB  1 
ATOM   1846 C  CG  . ASP   A 1 281 ? -9.176  -24.150 6.495   1.00 61.64  ? 447 ASP   A CG  1 
ATOM   1847 O  OD1 . ASP   A 1 281 ? -8.516  -23.688 5.536   1.00 59.94  ? 447 ASP   A OD1 1 
ATOM   1848 O  OD2 . ASP   A 1 281 ? -9.183  -25.367 6.809   1.00 62.79  ? 447 ASP   A OD2 1 
ATOM   1849 N  N   . MET   A 1 282 ? -7.819  -22.224 8.963   1.00 47.19  ? 448 MET   A N   1 
ATOM   1850 C  CA  . MET   A 1 282 ? -6.497  -22.189 9.567   1.00 40.41  ? 448 MET   A CA  1 
ATOM   1851 C  C   . MET   A 1 282 ? -5.510  -23.124 8.879   1.00 54.60  ? 448 MET   A C   1 
ATOM   1852 O  O   . MET   A 1 282 ? -4.298  -22.951 9.044   1.00 53.42  ? 448 MET   A O   1 
ATOM   1853 C  CB  . MET   A 1 282 ? -6.600  -22.536 11.055  1.00 52.15  ? 448 MET   A CB  1 
ATOM   1854 C  CG  . MET   A 1 282 ? -7.383  -21.512 11.899  1.00 45.54  ? 448 MET   A CG  1 
ATOM   1855 S  SD  . MET   A 1 282 ? -6.517  -19.936 11.986  1.00 52.61  ? 448 MET   A SD  1 
ATOM   1856 C  CE  . MET   A 1 282 ? -7.631  -18.866 12.896  1.00 45.92  ? 448 MET   A CE  1 
ATOM   1857 N  N   . HIS   A 1 283 ? -5.987  -24.093 8.098   1.00 55.54  ? 449 HIS   A N   1 
ATOM   1858 C  CA  . HIS   A 1 283 ? -5.108  -25.098 7.508   1.00 57.89  ? 449 HIS   A CA  1 
ATOM   1859 C  C   . HIS   A 1 283 ? -4.748  -24.797 6.056   1.00 59.84  ? 449 HIS   A C   1 
ATOM   1860 O  O   . HIS   A 1 283 ? -3.575  -24.886 5.680   1.00 59.63  ? 449 HIS   A O   1 
ATOM   1861 C  CB  . HIS   A 1 283 ? -5.752  -26.487 7.616   1.00 61.03  ? 449 HIS   A CB  1 
ATOM   1862 C  CG  . HIS   A 1 283 ? -6.176  -26.851 9.007   1.00 76.70  ? 449 HIS   A CG  1 
ATOM   1863 N  ND1 . HIS   A 1 283 ? -5.286  -27.268 9.973   1.00 76.15  ? 449 HIS   A ND1 1 
ATOM   1864 C  CD2 . HIS   A 1 283 ? -7.397  -26.854 9.595   1.00 74.24  ? 449 HIS   A CD2 1 
ATOM   1865 C  CE1 . HIS   A 1 283 ? -5.940  -27.517 11.094  1.00 67.89  ? 449 HIS   A CE1 1 
ATOM   1866 N  NE2 . HIS   A 1 283 ? -7.223  -27.274 10.892  1.00 67.20  ? 449 HIS   A NE2 1 
ATOM   1867 N  N   . SER   A 1 284 ? -5.727  -24.446 5.229   1.00 59.87  ? 450 SER   A N   1 
ATOM   1868 C  CA  . SER   A 1 284 ? -5.506  -24.191 3.810   1.00 56.25  ? 450 SER   A CA  1 
ATOM   1869 C  C   . SER   A 1 284 ? -5.953  -22.782 3.431   1.00 58.74  ? 450 SER   A C   1 
ATOM   1870 O  O   . SER   A 1 284 ? -6.520  -22.553 2.359   1.00 60.95  ? 450 SER   A O   1 
ATOM   1871 C  CB  . SER   A 1 284 ? -6.221  -25.235 2.956   1.00 54.14  ? 450 SER   A CB  1 
ATOM   1872 O  OG  . SER   A 1 284 ? -7.630  -25.149 3.099   1.00 52.46  ? 450 SER   A OG  1 
ATOM   1873 N  N   . GLY   A 1 285 ? -5.696  -21.821 4.311   1.00 50.54  ? 451 GLY   A N   1 
ATOM   1874 C  CA  . GLY   A 1 285 ? -6.064  -20.439 4.087   1.00 50.44  ? 451 GLY   A CA  1 
ATOM   1875 C  C   . GLY   A 1 285 ? -5.091  -19.702 3.190   1.00 42.58  ? 451 GLY   A C   1 
ATOM   1876 O  O   . GLY   A 1 285 ? -4.323  -20.298 2.431   1.00 51.32  ? 451 GLY   A O   1 
ATOM   1877 N  N   . HIS   A 1 286 ? -5.141  -18.376 3.279   1.00 34.78  ? 452 HIS   A N   1 
ATOM   1878 C  CA  . HIS   A 1 286 ? -4.285  -17.487 2.504   1.00 33.49  ? 452 HIS   A CA  1 
ATOM   1879 C  C   . HIS   A 1 286 ? -4.364  -16.086 3.095   1.00 35.40  ? 452 HIS   A C   1 
ATOM   1880 O  O   . HIS   A 1 286 ? -5.428  -15.652 3.550   1.00 33.48  ? 452 HIS   A O   1 
ATOM   1881 C  CB  . HIS   A 1 286 ? -4.688  -17.462 1.025   1.00 23.10  ? 452 HIS   A CB  1 
ATOM   1882 C  CG  . HIS   A 1 286 ? -3.738  -16.696 0.159   1.00 29.26  ? 452 HIS   A CG  1 
ATOM   1883 N  ND1 . HIS   A 1 286 ? -2.427  -17.077 -0.026  1.00 38.54  ? 452 HIS   A ND1 1 
ATOM   1884 C  CD2 . HIS   A 1 286 ? -3.906  -15.565 -0.569  1.00 35.66  ? 452 HIS   A CD2 1 
ATOM   1885 C  CE1 . HIS   A 1 286 ? -1.831  -16.221 -0.837  1.00 41.17  ? 452 HIS   A CE1 1 
ATOM   1886 N  NE2 . HIS   A 1 286 ? -2.705  -15.289 -1.174  1.00 42.86  ? 452 HIS   A NE2 1 
ATOM   1887 N  N   . PHE   A 1 287 ? -3.230  -15.386 3.080   1.00 30.50  ? 453 PHE   A N   1 
ATOM   1888 C  CA  . PHE   A 1 287 ? -3.154  -14.015 3.570   1.00 35.49  ? 453 PHE   A CA  1 
ATOM   1889 C  C   . PHE   A 1 287 ? -3.162  -13.052 2.386   1.00 31.99  ? 453 PHE   A C   1 
ATOM   1890 O  O   . PHE   A 1 287 ? -2.471  -13.286 1.389   1.00 34.66  ? 453 PHE   A O   1 
ATOM   1891 C  CB  . PHE   A 1 287 ? -1.898  -13.812 4.428   1.00 37.70  ? 453 PHE   A CB  1 
ATOM   1892 C  CG  . PHE   A 1 287 ? -2.103  -14.141 5.881   1.00 33.22  ? 453 PHE   A CG  1 
ATOM   1893 C  CD1 . PHE   A 1 287 ? -2.884  -13.327 6.679   1.00 28.05  ? 453 PHE   A CD1 1 
ATOM   1894 C  CD2 . PHE   A 1 287 ? -1.538  -15.277 6.440   1.00 32.07  ? 453 PHE   A CD2 1 
ATOM   1895 C  CE1 . PHE   A 1 287 ? -3.089  -13.620 8.013   1.00 24.56  ? 453 PHE   A CE1 1 
ATOM   1896 C  CE2 . PHE   A 1 287 ? -1.746  -15.583 7.779   1.00 38.57  ? 453 PHE   A CE2 1 
ATOM   1897 C  CZ  . PHE   A 1 287 ? -2.523  -14.746 8.565   1.00 36.87  ? 453 PHE   A CZ  1 
ATOM   1898 N  N   . VAL   A 1 288 ? -3.977  -11.997 2.479   1.00 24.70  ? 454 VAL   A N   1 
ATOM   1899 C  CA  . VAL   A 1 288 ? -3.973  -10.915 1.498   1.00 27.37  ? 454 VAL   A CA  1 
ATOM   1900 C  C   . VAL   A 1 288 ? -4.008  -9.590  2.243   1.00 28.82  ? 454 VAL   A C   1 
ATOM   1901 O  O   . VAL   A 1 288 ? -4.355  -9.524  3.426   1.00 29.90  ? 454 VAL   A O   1 
ATOM   1902 C  CB  . VAL   A 1 288 ? -5.143  -10.979 0.473   1.00 31.18  ? 454 VAL   A CB  1 
ATOM   1903 C  CG1 . VAL   A 1 288 ? -5.189  -12.331 -0.223  1.00 34.08  ? 454 VAL   A CG1 1 
ATOM   1904 C  CG2 . VAL   A 1 288 ? -6.493  -10.624 1.119   1.00 32.89  ? 454 VAL   A CG2 1 
ATOM   1905 N  N   . THR   A 1 289 ? -3.641  -8.528  1.534   1.00 27.64  ? 455 THR   A N   1 
ATOM   1906 C  CA  . THR   A 1 289 ? -3.528  -7.202  2.117   1.00 29.84  ? 455 THR   A CA  1 
ATOM   1907 C  C   . THR   A 1 289 ? -4.211  -6.190  1.214   1.00 28.13  ? 455 THR   A C   1 
ATOM   1908 O  O   . THR   A 1 289 ? -4.033  -6.222  -0.007  1.00 26.83  ? 455 THR   A O   1 
ATOM   1909 C  CB  . THR   A 1 289 ? -2.060  -6.816  2.328   1.00 26.28  ? 455 THR   A CB  1 
ATOM   1910 O  OG1 . THR   A 1 289 ? -1.552  -7.496  3.481   1.00 44.09  ? 455 THR   A OG1 1 
ATOM   1911 C  CG2 . THR   A 1 289 ? -1.924  -5.318  2.551   1.00 25.42  ? 455 THR   A CG2 1 
ATOM   1912 N  N   . TYR   A 1 290 ? -5.012  -5.320  1.817   1.00 30.73  ? 456 TYR   A N   1 
ATOM   1913 C  CA  . TYR   A 1 290 ? -5.470  -4.099  1.172   1.00 33.48  ? 456 TYR   A CA  1 
ATOM   1914 C  C   . TYR   A 1 290 ? -4.577  -2.947  1.617   1.00 32.07  ? 456 TYR   A C   1 
ATOM   1915 O  O   . TYR   A 1 290 ? -4.281  -2.810  2.807   1.00 32.15  ? 456 TYR   A O   1 
ATOM   1916 C  CB  . TYR   A 1 290 ? -6.925  -3.803  1.541   1.00 30.27  ? 456 TYR   A CB  1 
ATOM   1917 C  CG  . TYR   A 1 290 ? -7.939  -4.734  0.911   1.00 37.52  ? 456 TYR   A CG  1 
ATOM   1918 C  CD1 . TYR   A 1 290 ? -8.400  -4.507  -0.381  1.00 28.48  ? 456 TYR   A CD1 1 
ATOM   1919 C  CD2 . TYR   A 1 290 ? -8.451  -5.831  1.613   1.00 37.15  ? 456 TYR   A CD2 1 
ATOM   1920 C  CE1 . TYR   A 1 290 ? -9.331  -5.345  -0.965  1.00 36.33  ? 456 TYR   A CE1 1 
ATOM   1921 C  CE2 . TYR   A 1 290 ? -9.390  -6.673  1.037   1.00 32.74  ? 456 TYR   A CE2 1 
ATOM   1922 C  CZ  . TYR   A 1 290 ? -9.824  -6.422  -0.255  1.00 41.01  ? 456 TYR   A CZ  1 
ATOM   1923 O  OH  . TYR   A 1 290 ? -10.748 -7.242  -0.851  1.00 36.43  ? 456 TYR   A OH  1 
ATOM   1924 N  N   . ARG   A 1 291 ? -4.142  -2.123  0.664   1.00 31.77  ? 457 ARG   A N   1 
ATOM   1925 C  CA  . ARG   A 1 291 ? -3.250  -1.020  1.003   1.00 26.42  ? 457 ARG   A CA  1 
ATOM   1926 C  C   . ARG   A 1 291 ? -3.512  0.178   0.103   1.00 30.97  ? 457 ARG   A C   1 
ATOM   1927 O  O   . ARG   A 1 291 ? -3.989  0.046   -1.029  1.00 28.63  ? 457 ARG   A O   1 
ATOM   1928 C  CB  . ARG   A 1 291 ? -1.782  -1.434  0.887   1.00 33.00  ? 457 ARG   A CB  1 
ATOM   1929 C  CG  . ARG   A 1 291 ? -1.391  -1.835  -0.525  1.00 37.38  ? 457 ARG   A CG  1 
ATOM   1930 C  CD  . ARG   A 1 291 ? 0.094   -1.834  -0.708  1.00 31.62  ? 457 ARG   A CD  1 
ATOM   1931 N  NE  . ARG   A 1 291 ? 0.655   -0.507  -0.483  1.00 40.07  ? 457 ARG   A NE  1 
ATOM   1932 C  CZ  . ARG   A 1 291 ? 1.947   -0.213  -0.596  1.00 37.84  ? 457 ARG   A CZ  1 
ATOM   1933 N  NH1 . ARG   A 1 291 ? 2.818   -1.155  -0.936  1.00 34.04  ? 457 ARG   A NH1 1 
ATOM   1934 N  NH2 . ARG   A 1 291 ? 2.365   1.027   -0.384  1.00 39.06  ? 457 ARG   A NH2 1 
ATOM   1935 N  N   . ARG   A 1 292 ? -3.163  1.355   0.616   1.00 32.80  ? 458 ARG   A N   1 
ATOM   1936 C  CA  . ARG   A 1 292 ? -3.292  2.584   -0.146  1.00 30.20  ? 458 ARG   A CA  1 
ATOM   1937 C  C   . ARG   A 1 292 ? -2.200  2.680   -1.204  1.00 37.79  ? 458 ARG   A C   1 
ATOM   1938 O  O   . ARG   A 1 292 ? -1.108  2.118   -1.072  1.00 31.88  ? 458 ARG   A O   1 
ATOM   1939 C  CB  . ARG   A 1 292 ? -3.212  3.798   0.771   1.00 34.34  ? 458 ARG   A CB  1 
ATOM   1940 C  CG  . ARG   A 1 292 ? -4.386  3.936   1.704   1.00 35.52  ? 458 ARG   A CG  1 
ATOM   1941 C  CD  . ARG   A 1 292 ? -4.222  5.172   2.551   1.00 35.87  ? 458 ARG   A CD  1 
ATOM   1942 N  NE  . ARG   A 1 292 ? -5.335  5.354   3.475   1.00 45.97  ? 458 ARG   A NE  1 
ATOM   1943 C  CZ  . ARG   A 1 292 ? -6.419  6.069   3.205   1.00 36.79  ? 458 ARG   A CZ  1 
ATOM   1944 N  NH1 . ARG   A 1 292 ? -6.543  6.666   2.027   1.00 39.63  ? 458 ARG   A NH1 1 
ATOM   1945 N  NH2 . ARG   A 1 292 ? -7.374  6.187   4.114   1.00 40.75  ? 458 ARG   A NH2 1 
ATOM   1946 N  N   . SER   A 1 293 ? -2.508  3.415   -2.265  1.00 42.13  ? 459 SER   A N   1 
ATOM   1947 C  CA  . SER   A 1 293 ? -1.514  3.682   -3.284  1.00 30.67  ? 459 SER   A CA  1 
ATOM   1948 C  C   . SER   A 1 293 ? -0.441  4.616   -2.736  1.00 36.79  ? 459 SER   A C   1 
ATOM   1949 O  O   . SER   A 1 293 ? -0.717  5.463   -1.882  1.00 32.83  ? 459 SER   A O   1 
ATOM   1950 C  CB  . SER   A 1 293 ? -2.163  4.304   -4.513  1.00 36.41  ? 459 SER   A CB  1 
ATOM   1951 O  OG  . SER   A 1 293 ? -2.936  3.345   -5.206  1.00 43.58  ? 459 SER   A OG  1 
ATOM   1952 N  N   . PRO   A 1 294 ? 0.795   4.474   -3.204  1.00 49.48  ? 460 PRO   A N   1 
ATOM   1953 C  CA  . PRO   A 1 294 ? 1.849   5.373   -2.760  1.00 47.29  ? 460 PRO   A CA  1 
ATOM   1954 C  C   . PRO   A 1 294 ? 1.576   6.789   -3.229  1.00 49.01  ? 460 PRO   A C   1 
ATOM   1955 O  O   . PRO   A 1 294 ? 1.066   7.008   -4.345  1.00 52.44  ? 460 PRO   A O   1 
ATOM   1956 C  CB  . PRO   A 1 294 ? 3.107   4.793   -3.417  1.00 49.93  ? 460 PRO   A CB  1 
ATOM   1957 C  CG  . PRO   A 1 294 ? 2.590   4.068   -4.614  1.00 51.38  ? 460 PRO   A CG  1 
ATOM   1958 C  CD  . PRO   A 1 294 ? 1.297   3.468   -4.155  1.00 45.70  ? 460 PRO   A CD  1 
ATOM   1959 N  N   . PRO   A 1 295 ? 1.893   7.779   -2.407  1.00 54.40  ? 461 PRO   A N   1 
ATOM   1960 C  CA  . PRO   A 1 295 ? 1.589   9.173   -2.754  1.00 55.46  ? 461 PRO   A CA  1 
ATOM   1961 C  C   . PRO   A 1 295 ? 2.366   9.640   -3.978  1.00 58.89  ? 461 PRO   A C   1 
ATOM   1962 O  O   . PRO   A 1 295 ? 3.414   9.095   -4.333  1.00 54.64  ? 461 PRO   A O   1 
ATOM   1963 C  CB  . PRO   A 1 295 ? 2.020   9.948   -1.503  1.00 53.29  ? 461 PRO   A CB  1 
ATOM   1964 C  CG  . PRO   A 1 295 ? 3.064   9.065   -0.865  1.00 63.01  ? 461 PRO   A CG  1 
ATOM   1965 C  CD  . PRO   A 1 295 ? 2.618   7.655   -1.135  1.00 44.73  ? 461 PRO   A CD  1 
ATOM   1966 N  N   . SER   A 1 296 ? 1.831   10.677  -4.622  1.00 67.46  ? 462 SER   A N   1 
ATOM   1967 C  CA  . SER   A 1 296 ? 2.443   11.264  -5.814  1.00 70.82  ? 462 SER   A CA  1 
ATOM   1968 C  C   . SER   A 1 296 ? 3.403   12.396  -5.451  1.00 77.06  ? 462 SER   A C   1 
ATOM   1969 O  O   . SER   A 1 296 ? 3.017   13.567  -5.436  1.00 94.06  ? 462 SER   A O   1 
ATOM   1970 C  CB  . SER   A 1 296 ? 1.362   11.785  -6.769  1.00 71.82  ? 462 SER   A CB  1 
ATOM   1971 O  OG  . SER   A 1 296 ? 0.444   10.761  -7.114  1.00 79.56  ? 462 SER   A OG  1 
ATOM   1972 N  N   . PRO   A 1 300 ? 3.703   14.117  -2.298  1.00 58.36  ? 466 PRO   A N   1 
ATOM   1973 C  CA  . PRO   A 1 300 ? 4.371   13.579  -1.106  1.00 58.50  ? 466 PRO   A CA  1 
ATOM   1974 C  C   . PRO   A 1 300 ? 3.662   13.997  0.179   1.00 64.62  ? 466 PRO   A C   1 
ATOM   1975 O  O   . PRO   A 1 300 ? 3.079   15.089  0.226   1.00 65.53  ? 466 PRO   A O   1 
ATOM   1976 C  CB  . PRO   A 1 300 ? 5.776   14.185  -1.178  1.00 43.15  ? 466 PRO   A CB  1 
ATOM   1977 C  CG  . PRO   A 1 300 ? 5.603   15.427  -1.983  1.00 50.77  ? 466 PRO   A CG  1 
ATOM   1978 C  CD  . PRO   A 1 300 ? 4.526   15.125  -2.987  1.00 67.81  ? 466 PRO   A CD  1 
ATOM   1979 N  N   . LEU   A 1 301 ? 3.702   13.122  1.190   1.00 57.83  ? 467 LEU   A N   1 
ATOM   1980 C  CA  . LEU   A 1 301 ? 3.115   13.359  2.508   1.00 52.22  ? 467 LEU   A CA  1 
ATOM   1981 C  C   . LEU   A 1 301 ? 1.593   13.444  2.461   1.00 56.00  ? 467 LEU   A C   1 
ATOM   1982 O  O   . LEU   A 1 301 ? 0.938   13.529  3.506   1.00 44.43  ? 467 LEU   A O   1 
ATOM   1983 C  CB  . LEU   A 1 301 ? 3.681   14.635  3.143   1.00 45.80  ? 467 LEU   A CB  1 
ATOM   1984 C  CG  . LEU   A 1 301 ? 5.093   14.549  3.706   1.00 47.66  ? 467 LEU   A CG  1 
ATOM   1985 C  CD1 . LEU   A 1 301 ? 5.329   15.704  4.647   1.00 52.30  ? 467 LEU   A CD1 1 
ATOM   1986 C  CD2 . LEU   A 1 301 ? 5.312   13.217  4.414   1.00 54.12  ? 467 LEU   A CD2 1 
ATOM   1987 N  N   . SER   A 1 302 ? 1.016   13.412  1.266   1.00 64.13  ? 468 SER   A N   1 
ATOM   1988 C  CA  . SER   A 1 302 ? -0.430  13.454  1.097   1.00 60.80  ? 468 SER   A CA  1 
ATOM   1989 C  C   . SER   A 1 302 ? -0.923  12.033  0.832   1.00 62.83  ? 468 SER   A C   1 
ATOM   1990 O  O   . SER   A 1 302 ? -0.519  11.404  -0.153  1.00 57.21  ? 468 SER   A O   1 
ATOM   1991 C  CB  . SER   A 1 302 ? -0.823  14.400  -0.040  1.00 52.50  ? 468 SER   A CB  1 
ATOM   1992 O  OG  . SER   A 1 302 ? -2.012  13.976  -0.690  1.00 62.40  ? 468 SER   A OG  1 
ATOM   1993 N  N   . THR   A 1 303 ? -1.774  11.523  1.724   1.00 55.83  ? 469 THR   A N   1 
ATOM   1994 C  CA  . THR   A 1 303 ? -2.262  10.156  1.595   1.00 41.63  ? 469 THR   A CA  1 
ATOM   1995 C  C   . THR   A 1 303 ? -3.215  10.039  0.408   1.00 45.11  ? 469 THR   A C   1 
ATOM   1996 O  O   . THR   A 1 303 ? -4.119  10.864  0.237   1.00 40.80  ? 469 THR   A O   1 
ATOM   1997 C  CB  . THR   A 1 303 ? -2.955  9.715   2.884   1.00 43.12  ? 469 THR   A CB  1 
ATOM   1998 O  OG1 . THR   A 1 303 ? -4.268  10.279  2.933   1.00 57.39  ? 469 THR   A OG1 1 
ATOM   1999 C  CG2 . THR   A 1 303 ? -2.161  10.188  4.106   1.00 45.39  ? 469 THR   A CG2 1 
ATOM   2000 N  N   . SER   A 1 304 ? -2.999  9.015   -0.416  1.00 40.68  ? 470 SER   A N   1 
ATOM   2001 C  CA  . SER   A 1 304 ? -3.832  8.755   -1.581  1.00 33.38  ? 470 SER   A CA  1 
ATOM   2002 C  C   . SER   A 1 304 ? -5.167  8.129   -1.179  1.00 45.25  ? 470 SER   A C   1 
ATOM   2003 O  O   . SER   A 1 304 ? -5.263  7.383   -0.197  1.00 39.76  ? 470 SER   A O   1 
ATOM   2004 C  CB  . SER   A 1 304 ? -3.098  7.828   -2.555  1.00 35.74  ? 470 SER   A CB  1 
ATOM   2005 O  OG  . SER   A 1 304 ? -3.994  6.985   -3.263  1.00 39.87  ? 470 SER   A OG  1 
ATOM   2006 N  N   . ASN   A 1 305 ? -6.207  8.439   -1.958  1.00 38.63  ? 471 ASN   A N   1 
ATOM   2007 C  CA  . ASN   A 1 305 ? -7.522  7.826   -1.799  1.00 32.33  ? 471 ASN   A CA  1 
ATOM   2008 C  C   . ASN   A 1 305 ? -7.670  6.524   -2.582  1.00 39.54  ? 471 ASN   A C   1 
ATOM   2009 O  O   . ASN   A 1 305 ? -8.730  5.890   -2.514  1.00 41.21  ? 471 ASN   A O   1 
ATOM   2010 C  CB  . ASN   A 1 305 ? -8.627  8.792   -2.245  1.00 43.06  ? 471 ASN   A CB  1 
ATOM   2011 C  CG  . ASN   A 1 305 ? -8.598  10.110  -1.507  1.00 44.55  ? 471 ASN   A CG  1 
ATOM   2012 O  OD1 . ASN   A 1 305 ? -8.505  10.149  -0.278  1.00 42.45  ? 471 ASN   A OD1 1 
ATOM   2013 N  ND2 . ASN   A 1 305 ? -8.676  11.207  -2.259  1.00 50.88  ? 471 ASN   A ND2 1 
ATOM   2014 N  N   . GLN   A 1 306 ? -6.652  6.121   -3.335  1.00 38.35  ? 472 GLN   A N   1 
ATOM   2015 C  CA  . GLN   A 1 306 ? -6.730  4.931   -4.170  1.00 36.31  ? 472 GLN   A CA  1 
ATOM   2016 C  C   . GLN   A 1 306 ? -6.218  3.728   -3.381  1.00 35.04  ? 472 GLN   A C   1 
ATOM   2017 O  O   . GLN   A 1 306 ? -5.029  3.652   -3.043  1.00 31.25  ? 472 GLN   A O   1 
ATOM   2018 C  CB  . GLN   A 1 306 ? -5.931  5.134   -5.458  1.00 35.69  ? 472 GLN   A CB  1 
ATOM   2019 C  CG  . GLN   A 1 306 ? -5.968  3.962   -6.435  1.00 29.40  ? 472 GLN   A CG  1 
ATOM   2020 C  CD  . GLN   A 1 306 ? -7.315  3.810   -7.117  1.00 47.83  ? 472 GLN   A CD  1 
ATOM   2021 O  OE1 . GLN   A 1 306 ? -7.660  4.568   -8.035  1.00 49.64  ? 472 GLN   A OE1 1 
ATOM   2022 N  NE2 . GLN   A 1 306 ? -8.093  2.829   -6.664  1.00 47.14  ? 472 GLN   A NE2 1 
ATOM   2023 N  N   . TRP   A 1 307 ? -7.117  2.798   -3.081  1.00 34.32  ? 473 TRP   A N   1 
ATOM   2024 C  CA  . TRP   A 1 307 ? -6.759  1.552   -2.422  1.00 37.28  ? 473 TRP   A CA  1 
ATOM   2025 C  C   . TRP   A 1 307 ? -6.350  0.505   -3.456  1.00 38.03  ? 473 TRP   A C   1 
ATOM   2026 O  O   . TRP   A 1 307 ? -6.734  0.569   -4.627  1.00 39.03  ? 473 TRP   A O   1 
ATOM   2027 C  CB  . TRP   A 1 307 ? -7.926  1.050   -1.568  1.00 28.88  ? 473 TRP   A CB  1 
ATOM   2028 C  CG  . TRP   A 1 307 ? -8.101  1.905   -0.361  1.00 28.22  ? 473 TRP   A CG  1 
ATOM   2029 C  CD1 . TRP   A 1 307 ? -8.722  3.115   -0.299  1.00 30.70  ? 473 TRP   A CD1 1 
ATOM   2030 C  CD2 . TRP   A 1 307 ? -7.603  1.642   0.950   1.00 27.03  ? 473 TRP   A CD2 1 
ATOM   2031 N  NE1 . TRP   A 1 307 ? -8.662  3.614   0.978   1.00 30.75  ? 473 TRP   A NE1 1 
ATOM   2032 C  CE2 . TRP   A 1 307 ? -7.979  2.724   1.765   1.00 32.83  ? 473 TRP   A CE2 1 
ATOM   2033 C  CE3 . TRP   A 1 307 ? -6.891  0.586   1.520   1.00 31.25  ? 473 TRP   A CE3 1 
ATOM   2034 C  CZ2 . TRP   A 1 307 ? -7.655  2.787   3.119   1.00 33.94  ? 473 TRP   A CZ2 1 
ATOM   2035 C  CZ3 . TRP   A 1 307 ? -6.576  0.647   2.865   1.00 32.72  ? 473 TRP   A CZ3 1 
ATOM   2036 C  CH2 . TRP   A 1 307 ? -6.956  1.741   3.649   1.00 32.26  ? 473 TRP   A CH2 1 
ATOM   2037 N  N   . LEU   A 1 308 ? -5.531  -0.447  -3.012  1.00 28.86  ? 474 LEU   A N   1 
ATOM   2038 C  CA  . LEU   A 1 308 ? -5.062  -1.540  -3.851  1.00 32.31  ? 474 LEU   A CA  1 
ATOM   2039 C  C   . LEU   A 1 308 ? -5.325  -2.865  -3.159  1.00 27.24  ? 474 LEU   A C   1 
ATOM   2040 O  O   . LEU   A 1 308 ? -5.339  -2.948  -1.929  1.00 32.85  ? 474 LEU   A O   1 
ATOM   2041 C  CB  . LEU   A 1 308 ? -3.568  -1.428  -4.151  1.00 35.08  ? 474 LEU   A CB  1 
ATOM   2042 C  CG  . LEU   A 1 308 ? -3.157  -0.078  -4.722  1.00 38.62  ? 474 LEU   A CG  1 
ATOM   2043 C  CD1 . LEU   A 1 308 ? -1.676  0.142   -4.566  1.00 36.10  ? 474 LEU   A CD1 1 
ATOM   2044 C  CD2 . LEU   A 1 308 ? -3.581  0.003   -6.178  1.00 38.52  ? 474 LEU   A CD2 1 
ATOM   2045 N  N   . TRP   A 1 309 ? -5.524  -3.902  -3.961  1.00 32.76  ? 475 TRP   A N   1 
ATOM   2046 C  CA  . TRP   A 1 309 ? -5.629  -5.274  -3.478  1.00 26.15  ? 475 TRP   A CA  1 
ATOM   2047 C  C   . TRP   A 1 309 ? -4.377  -6.004  -3.933  1.00 31.52  ? 475 TRP   A C   1 
ATOM   2048 O  O   . TRP   A 1 309 ? -4.074  -6.037  -5.132  1.00 39.87  ? 475 TRP   A O   1 
ATOM   2049 C  CB  . TRP   A 1 309 ? -6.888  -5.947  -4.012  1.00 34.52  ? 475 TRP   A CB  1 
ATOM   2050 C  CG  . TRP   A 1 309 ? -7.035  -7.382  -3.615  1.00 39.33  ? 475 TRP   A CG  1 
ATOM   2051 C  CD1 . TRP   A 1 309 ? -7.511  -7.862  -2.429  1.00 40.89  ? 475 TRP   A CD1 1 
ATOM   2052 C  CD2 . TRP   A 1 309 ? -6.736  -8.527  -4.417  1.00 34.72  ? 475 TRP   A CD2 1 
ATOM   2053 N  NE1 . TRP   A 1 309 ? -7.509  -9.235  -2.438  1.00 32.57  ? 475 TRP   A NE1 1 
ATOM   2054 C  CE2 . TRP   A 1 309 ? -7.042  -9.668  -3.649  1.00 34.57  ? 475 TRP   A CE2 1 
ATOM   2055 C  CE3 . TRP   A 1 309 ? -6.240  -8.699  -5.711  1.00 41.94  ? 475 TRP   A CE3 1 
ATOM   2056 C  CZ2 . TRP   A 1 309 ? -6.868  -10.962 -4.130  1.00 43.92  ? 475 TRP   A CZ2 1 
ATOM   2057 C  CZ3 . TRP   A 1 309 ? -6.064  -9.991  -6.188  1.00 42.40  ? 475 TRP   A CZ3 1 
ATOM   2058 C  CH2 . TRP   A 1 309 ? -6.382  -11.102 -5.400  1.00 38.19  ? 475 TRP   A CH2 1 
ATOM   2059 N  N   . VAL   A 1 310 ? -3.638  -6.569  -2.983  1.00 28.65  ? 476 VAL   A N   1 
ATOM   2060 C  CA  . VAL   A 1 310 ? -2.379  -7.243  -3.271  1.00 27.59  ? 476 VAL   A CA  1 
ATOM   2061 C  C   . VAL   A 1 310 ? -2.471  -8.663  -2.740  1.00 29.30  ? 476 VAL   A C   1 
ATOM   2062 O  O   . VAL   A 1 310 ? -2.503  -8.880  -1.522  1.00 24.82  ? 476 VAL   A O   1 
ATOM   2063 C  CB  . VAL   A 1 310 ? -1.174  -6.514  -2.664  1.00 35.14  ? 476 VAL   A CB  1 
ATOM   2064 C  CG1 . VAL   A 1 310 ? 0.105   -7.180  -3.128  1.00 34.27  ? 476 VAL   A CG1 1 
ATOM   2065 C  CG2 . VAL   A 1 310 ? -1.176  -5.044  -3.059  1.00 34.20  ? 476 VAL   A CG2 1 
ATOM   2066 N  N   . SER   A 1 311 ? -2.494  -9.633  -3.650  1.00 34.10  ? 477 SER   A N   1 
ATOM   2067 C  CA  . SER   A 1 311 ? -2.384  -11.050 -3.310  1.00 33.59  ? 477 SER   A CA  1 
ATOM   2068 C  C   . SER   A 1 311 ? -1.050  -11.557 -3.849  1.00 45.29  ? 477 SER   A C   1 
ATOM   2069 O  O   . SER   A 1 311 ? -0.983  -12.063 -4.973  1.00 48.24  ? 477 SER   A O   1 
ATOM   2070 C  CB  . SER   A 1 311 ? -3.536  -11.846 -3.873  1.00 36.41  ? 477 SER   A CB  1 
ATOM   2071 O  OG  . SER   A 1 311 ? -3.489  -13.185 -3.417  1.00 34.77  ? 477 SER   A OG  1 
ATOM   2072 N  N   . ASP   A 1 312 ? 0.004   -11.424 -3.037  1.00 42.31  ? 478 ASP   A N   1 
ATOM   2073 C  CA  . ASP   A 1 312 ? 1.370   -11.746 -3.440  1.00 32.14  ? 478 ASP   A CA  1 
ATOM   2074 C  C   . ASP   A 1 312 ? 1.786   -10.992 -4.696  1.00 37.11  ? 478 ASP   A C   1 
ATOM   2075 O  O   . ASP   A 1 312 ? 1.976   -9.774  -4.656  1.00 37.15  ? 478 ASP   A O   1 
ATOM   2076 C  CB  . ASP   A 1 312 ? 1.529   -13.247 -3.657  1.00 37.02  ? 478 ASP   A CB  1 
ATOM   2077 C  CG  . ASP   A 1 312 ? 1.238   -14.036 -2.409  1.00 43.64  ? 478 ASP   A CG  1 
ATOM   2078 O  OD1 . ASP   A 1 312 ? 1.591   -13.549 -1.316  1.00 49.33  ? 478 ASP   A OD1 1 
ATOM   2079 O  OD2 . ASP   A 1 312 ? 0.650   -15.132 -2.514  1.00 45.16  ? 478 ASP   A OD2 1 
ATOM   2080 N  N   . ASP   A 1 313 ? 1.928   -11.705 -5.815  1.00 36.08  ? 479 ASP   A N   1 
ATOM   2081 C  CA  . ASP   A 1 313 ? 2.406   -11.080 -7.041  1.00 37.52  ? 479 ASP   A CA  1 
ATOM   2082 C  C   . ASP   A 1 313 ? 1.313   -10.338 -7.795  1.00 39.76  ? 479 ASP   A C   1 
ATOM   2083 O  O   . ASP   A 1 313 ? 1.626   -9.544  -8.689  1.00 40.55  ? 479 ASP   A O   1 
ATOM   2084 C  CB  . ASP   A 1 313 ? 3.039   -12.127 -7.964  1.00 43.42  ? 479 ASP   A CB  1 
ATOM   2085 C  CG  . ASP   A 1 313 ? 2.063   -13.227 -8.365  1.00 63.22  ? 479 ASP   A CG  1 
ATOM   2086 O  OD1 . ASP   A 1 313 ? 1.543   -13.932 -7.465  1.00 64.65  ? 479 ASP   A OD1 1 
ATOM   2087 O  OD2 . ASP   A 1 313 ? 1.819   -13.385 -9.582  1.00 67.64  ? 479 ASP   A OD2 1 
ATOM   2088 N  N   . THR   A 1 314 ? 0.047   -10.564 -7.460  1.00 35.80  ? 480 THR   A N   1 
ATOM   2089 C  CA  . THR   A 1 314 ? -1.052  -9.937  -8.183  1.00 39.14  ? 480 THR   A CA  1 
ATOM   2090 C  C   . THR   A 1 314 ? -1.449  -8.647  -7.483  1.00 32.83  ? 480 THR   A C   1 
ATOM   2091 O  O   . THR   A 1 314 ? -1.776  -8.654  -6.293  1.00 41.29  ? 480 THR   A O   1 
ATOM   2092 C  CB  . THR   A 1 314 ? -2.248  -10.879 -8.292  1.00 41.98  ? 480 THR   A CB  1 
ATOM   2093 O  OG1 . THR   A 1 314 ? -1.891  -12.005 -9.105  1.00 41.12  ? 480 THR   A OG1 1 
ATOM   2094 C  CG2 . THR   A 1 314 ? -3.422  -10.152 -8.922  1.00 31.85  ? 480 THR   A CG2 1 
ATOM   2095 N  N   . VAL   A 1 315 ? -1.418  -7.544  -8.222  1.00 36.38  ? 481 VAL   A N   1 
ATOM   2096 C  CA  . VAL   A 1 315 ? -1.755  -6.227  -7.700  1.00 37.43  ? 481 VAL   A CA  1 
ATOM   2097 C  C   . VAL   A 1 315 ? -2.861  -5.648  -8.568  1.00 39.23  ? 481 VAL   A C   1 
ATOM   2098 O  O   . VAL   A 1 315 ? -2.661  -5.437  -9.770  1.00 45.05  ? 481 VAL   A O   1 
ATOM   2099 C  CB  . VAL   A 1 315 ? -0.542  -5.283  -7.684  1.00 32.73  ? 481 VAL   A CB  1 
ATOM   2100 C  CG1 . VAL   A 1 315 ? -0.936  -3.947  -7.085  1.00 35.59  ? 481 VAL   A CG1 1 
ATOM   2101 C  CG2 . VAL   A 1 315 ? 0.616   -5.907  -6.915  1.00 30.09  ? 481 VAL   A CG2 1 
ATOM   2102 N  N   . ARG   A 1 316 ? -4.020  -5.386  -7.966  1.00 41.55  ? 482 ARG   A N   1 
ATOM   2103 C  CA  . ARG   A 1 316 ? -5.144  -4.787  -8.671  1.00 39.88  ? 482 ARG   A CA  1 
ATOM   2104 C  C   . ARG   A 1 316 ? -5.672  -3.607  -7.865  1.00 41.22  ? 482 ARG   A C   1 
ATOM   2105 O  O   . ARG   A 1 316 ? -5.450  -3.504  -6.655  1.00 39.35  ? 482 ARG   A O   1 
ATOM   2106 C  CB  . ARG   A 1 316 ? -6.271  -5.814  -8.937  1.00 40.18  ? 482 ARG   A CB  1 
ATOM   2107 C  CG  . ARG   A 1 316 ? -7.185  -6.063  -7.746  1.00 45.20  ? 482 ARG   A CG  1 
ATOM   2108 C  CD  . ARG   A 1 316 ? -8.614  -6.485  -8.137  1.00 53.13  ? 482 ARG   A CD  1 
ATOM   2109 N  NE  . ARG   A 1 316 ? -9.474  -6.603  -6.951  1.00 51.45  ? 482 ARG   A NE  1 
ATOM   2110 C  CZ  . ARG   A 1 316 ? -9.884  -7.757  -6.427  1.00 49.14  ? 482 ARG   A CZ  1 
ATOM   2111 N  NH1 . ARG   A 1 316 ? -9.537  -8.915  -6.983  1.00 45.60  ? 482 ARG   A NH1 1 
ATOM   2112 N  NH2 . ARG   A 1 316 ? -10.639 -7.755  -5.338  1.00 41.77  ? 482 ARG   A NH2 1 
ATOM   2113 N  N   . LYS   A 1 317 ? -6.362  -2.702  -8.559  1.00 42.52  ? 483 LYS   A N   1 
ATOM   2114 C  CA  . LYS   A 1 317 ? -6.986  -1.552  -7.918  1.00 40.68  ? 483 LYS   A CA  1 
ATOM   2115 C  C   . LYS   A 1 317 ? -8.287  -1.957  -7.231  1.00 43.20  ? 483 LYS   A C   1 
ATOM   2116 O  O   . LYS   A 1 317 ? -8.977  -2.891  -7.656  1.00 52.58  ? 483 LYS   A O   1 
ATOM   2117 C  CB  . LYS   A 1 317 ? -7.273  -0.450  -8.940  1.00 47.25  ? 483 LYS   A CB  1 
ATOM   2118 C  CG  . LYS   A 1 317 ? -6.068  0.386   -9.345  1.00 42.53  ? 483 LYS   A CG  1 
ATOM   2119 C  CD  . LYS   A 1 317 ? -6.381  1.316   -10.518 1.00 42.95  ? 483 LYS   A CD  1 
ATOM   2120 C  CE  . LYS   A 1 317 ? -5.918  2.743   -10.225 1.00 55.39  ? 483 LYS   A CE  1 
ATOM   2121 N  NZ  . LYS   A 1 317 ? -5.123  3.342   -11.351 1.00 55.48  ? 483 LYS   A NZ  1 
ATOM   2122 N  N   . ALA   A 1 318 ? -8.629  -1.232  -6.167  1.00 38.63  ? 484 ALA   A N   1 
ATOM   2123 C  CA  . ALA   A 1 318 ? -9.805  -1.545  -5.364  1.00 49.34  ? 484 ALA   A CA  1 
ATOM   2124 C  C   . ALA   A 1 318 ? -10.467 -0.262  -4.879  1.00 47.00  ? 484 ALA   A C   1 
ATOM   2125 O  O   . ALA   A 1 318 ? -9.888  0.827   -4.925  1.00 51.47  ? 484 ALA   A O   1 
ATOM   2126 C  CB  . ALA   A 1 318 ? -9.457  -2.437  -4.159  1.00 43.75  ? 484 ALA   A CB  1 
ATOM   2127 N  N   . SER   A 1 319 ? -11.688 -0.407  -4.385  1.00 43.10  ? 485 SER   A N   1 
ATOM   2128 C  CA  . SER   A 1 319 ? -12.447 0.710   -3.852  1.00 46.99  ? 485 SER   A CA  1 
ATOM   2129 C  C   . SER   A 1 319 ? -12.522 0.615   -2.336  1.00 33.52  ? 485 SER   A C   1 
ATOM   2130 O  O   . SER   A 1 319 ? -12.386 -0.462  -1.749  1.00 38.29  ? 485 SER   A O   1 
ATOM   2131 C  CB  . SER   A 1 319 ? -13.863 0.748   -4.434  1.00 39.23  ? 485 SER   A CB  1 
ATOM   2132 O  OG  . SER   A 1 319 ? -14.642 -0.307  -3.900  1.00 39.97  ? 485 SER   A OG  1 
ATOM   2133 N  N   . LEU   A 1 320 ? -12.746 1.768   -1.709  1.00 28.45  ? 486 LEU   A N   1 
ATOM   2134 C  CA  . LEU   A 1 320 ? -12.929 1.790   -0.267  1.00 29.36  ? 486 LEU   A CA  1 
ATOM   2135 C  C   . LEU   A 1 320 ? -14.077 0.889   0.167   1.00 38.36  ? 486 LEU   A C   1 
ATOM   2136 O  O   . LEU   A 1 320 ? -14.010 0.288   1.244   1.00 41.74  ? 486 LEU   A O   1 
ATOM   2137 C  CB  . LEU   A 1 320 ? -13.163 3.218   0.205   1.00 35.30  ? 486 LEU   A CB  1 
ATOM   2138 C  CG  . LEU   A 1 320 ? -13.156 3.463   1.708   1.00 38.13  ? 486 LEU   A CG  1 
ATOM   2139 C  CD1 . LEU   A 1 320 ? -11.890 2.925   2.336   1.00 29.51  ? 486 LEU   A CD1 1 
ATOM   2140 C  CD2 . LEU   A 1 320 ? -13.286 4.960   1.955   1.00 47.26  ? 486 LEU   A CD2 1 
ATOM   2141 N  N   . GLN   A 1 321 ? -15.127 0.756   -0.651  1.00 36.10  ? 487 GLN   A N   1 
ATOM   2142 C  CA  . GLN   A 1 321 ? -16.215 -0.132  -0.255  1.00 41.94  ? 487 GLN   A CA  1 
ATOM   2143 C  C   . GLN   A 1 321 ? -15.742 -1.577  -0.132  1.00 42.50  ? 487 GLN   A C   1 
ATOM   2144 O  O   . GLN   A 1 321 ? -16.180 -2.288  0.779   1.00 45.12  ? 487 GLN   A O   1 
ATOM   2145 C  CB  . GLN   A 1 321 ? -17.390 -0.033  -1.230  1.00 45.80  ? 487 GLN   A CB  1 
ATOM   2146 C  CG  . GLN   A 1 321 ? -18.760 -0.166  -0.557  1.00 56.39  ? 487 GLN   A CG  1 
ATOM   2147 C  CD  . GLN   A 1 321 ? -19.427 -1.514  -0.821  1.00 81.20  ? 487 GLN   A CD  1 
ATOM   2148 O  OE1 . GLN   A 1 321 ? -18.776 -2.473  -1.256  1.00 83.11  ? 487 GLN   A OE1 1 
ATOM   2149 N  NE2 . GLN   A 1 321 ? -20.738 -1.586  -0.575  1.00 75.14  ? 487 GLN   A NE2 1 
ATOM   2150 N  N   . GLU   A 1 322 ? -14.839 -2.024  -1.015  1.00 40.70  ? 488 GLU   A N   1 
ATOM   2151 C  CA  . GLU   A 1 322 ? -14.334 -3.393  -0.921  1.00 36.53  ? 488 GLU   A CA  1 
ATOM   2152 C  C   . GLU   A 1 322 ? -13.486 -3.582  0.334   1.00 40.95  ? 488 GLU   A C   1 
ATOM   2153 O  O   . GLU   A 1 322 ? -13.643 -4.577  1.054   1.00 39.04  ? 488 GLU   A O   1 
ATOM   2154 C  CB  . GLU   A 1 322 ? -13.535 -3.753  -2.178  1.00 27.42  ? 488 GLU   A CB  1 
ATOM   2155 C  CG  . GLU   A 1 322 ? -12.991 -5.187  -2.172  1.00 40.86  ? 488 GLU   A CG  1 
ATOM   2156 C  CD  . GLU   A 1 322 ? -12.289 -5.608  -3.474  1.00 52.03  ? 488 GLU   A CD  1 
ATOM   2157 O  OE1 . GLU   A 1 322 ? -11.791 -4.738  -4.225  1.00 49.24  ? 488 GLU   A OE1 1 
ATOM   2158 O  OE2 . GLU   A 1 322 ? -12.226 -6.831  -3.737  1.00 66.82  ? 488 GLU   A OE2 1 
ATOM   2159 N  N   . VAL   A 1 323 ? -12.597 -2.625  0.618   1.00 33.01  ? 489 VAL   A N   1 
ATOM   2160 C  CA  . VAL   A 1 323 ? -11.754 -2.688  1.808   1.00 30.83  ? 489 VAL   A CA  1 
ATOM   2161 C  C   . VAL   A 1 323 ? -12.600 -2.828  3.067   1.00 30.97  ? 489 VAL   A C   1 
ATOM   2162 O  O   . VAL   A 1 323 ? -12.346 -3.698  3.908   1.00 35.96  ? 489 VAL   A O   1 
ATOM   2163 C  CB  . VAL   A 1 323 ? -10.849 -1.442  1.871   1.00 34.89  ? 489 VAL   A CB  1 
ATOM   2164 C  CG1 . VAL   A 1 323 ? -9.946  -1.482  3.100   1.00 26.86  ? 489 VAL   A CG1 1 
ATOM   2165 C  CG2 . VAL   A 1 323 ? -10.036 -1.308  0.588   1.00 26.79  ? 489 VAL   A CG2 1 
ATOM   2166 N  N   . LEU   A 1 324 ? -13.624 -1.985  3.213   1.00 33.24  ? 490 LEU   A N   1 
ATOM   2167 C  CA  . LEU   A 1 324 ? -14.416 -1.962  4.438   1.00 35.13  ? 490 LEU   A CA  1 
ATOM   2168 C  C   . LEU   A 1 324 ? -15.288 -3.206  4.598   1.00 34.08  ? 490 LEU   A C   1 
ATOM   2169 O  O   . LEU   A 1 324 ? -15.596 -3.587  5.733   1.00 36.62  ? 490 LEU   A O   1 
ATOM   2170 C  CB  . LEU   A 1 324 ? -15.267 -0.683  4.480   1.00 28.33  ? 490 LEU   A CB  1 
ATOM   2171 C  CG  . LEU   A 1 324 ? -14.463 0.634   4.471   1.00 33.52  ? 490 LEU   A CG  1 
ATOM   2172 C  CD1 . LEU   A 1 324 ? -15.324 1.891   4.475   1.00 26.88  ? 490 LEU   A CD1 1 
ATOM   2173 C  CD2 . LEU   A 1 324 ? -13.498 0.672   5.642   1.00 35.35  ? 490 LEU   A CD2 1 
ATOM   2174 N  N   . SER   A 1 325 ? -15.667 -3.864  3.500   1.00 34.89  ? 491 SER   A N   1 
ATOM   2175 C  CA  . SER   A 1 325 ? -16.530 -5.041  3.561   1.00 33.77  ? 491 SER   A CA  1 
ATOM   2176 C  C   . SER   A 1 325 ? -15.784 -6.320  3.930   1.00 38.21  ? 491 SER   A C   1 
ATOM   2177 O  O   . SER   A 1 325 ? -16.409 -7.384  4.007   1.00 29.70  ? 491 SER   A O   1 
ATOM   2178 C  CB  . SER   A 1 325 ? -17.245 -5.239  2.220   1.00 37.82  ? 491 SER   A CB  1 
ATOM   2179 O  OG  . SER   A 1 325 ? -16.355 -5.731  1.229   1.00 56.58  ? 491 SER   A OG  1 
ATOM   2180 N  N   . SER   A 1 326 ? -14.478 -6.254  4.153   1.00 38.13  ? 492 SER   A N   1 
ATOM   2181 C  CA  . SER   A 1 326 ? -13.678 -7.440  4.412   1.00 36.59  ? 492 SER   A CA  1 
ATOM   2182 C  C   . SER   A 1 326 ? -13.516 -7.659  5.909   1.00 33.56  ? 492 SER   A C   1 
ATOM   2183 O  O   . SER   A 1 326 ? -13.617 -6.725  6.711   1.00 33.74  ? 492 SER   A O   1 
ATOM   2184 C  CB  . SER   A 1 326 ? -12.308 -7.323  3.744   1.00 30.17  ? 492 SER   A CB  1 
ATOM   2185 O  OG  . SER   A 1 326 ? -11.627 -6.165  4.187   1.00 35.41  ? 492 SER   A OG  1 
ATOM   2186 N  N   . SER   A 1 327 ? -13.276 -8.910  6.286   1.00 31.70  ? 493 SER   A N   1 
ATOM   2187 C  CA  . SER   A 1 327 ? -13.093 -9.232  7.697   1.00 36.56  ? 493 SER   A CA  1 
ATOM   2188 C  C   . SER   A 1 327 ? -11.618 -9.023  8.016   1.00 39.92  ? 493 SER   A C   1 
ATOM   2189 O  O   . SER   A 1 327 ? -10.767 -9.852  7.681   1.00 42.73  ? 493 SER   A O   1 
ATOM   2190 C  CB  . SER   A 1 327 ? -13.581 -10.644 8.007   1.00 33.96  ? 493 SER   A CB  1 
ATOM   2191 O  OG  . SER   A 1 327 ? -12.601 -11.619 7.726   1.00 50.03  ? 493 SER   A OG  1 
ATOM   2192 N  N   . ALA   A 1 328 ? -11.317 -7.889  8.645   1.00 35.40  ? 494 ALA   A N   1 
ATOM   2193 C  CA  . ALA   A 1 328 ? -9.938  -7.511  8.922   1.00 27.70  ? 494 ALA   A CA  1 
ATOM   2194 C  C   . ALA   A 1 328 ? -9.298  -8.464  9.923   1.00 34.78  ? 494 ALA   A C   1 
ATOM   2195 O  O   . ALA   A 1 328 ? -9.938  -8.915  10.877  1.00 35.69  ? 494 ALA   A O   1 
ATOM   2196 C  CB  . ALA   A 1 328 ? -9.879  -6.081  9.465   1.00 24.55  ? 494 ALA   A CB  1 
ATOM   2197 N  N   . TYR   A 1 329 ? -8.026  -8.777  9.693   1.00 30.87  ? 495 TYR   A N   1 
ATOM   2198 C  CA  . TYR   A 1 329 ? -7.195  -9.441  10.690  1.00 33.42  ? 495 TYR   A CA  1 
ATOM   2199 C  C   . TYR   A 1 329 ? -6.220  -8.491  11.368  1.00 31.50  ? 495 TYR   A C   1 
ATOM   2200 O  O   . TYR   A 1 329 ? -6.128  -8.480  12.600  1.00 34.82  ? 495 TYR   A O   1 
ATOM   2201 C  CB  . TYR   A 1 329 ? -6.422  -10.609 10.059  1.00 34.01  ? 495 TYR   A CB  1 
ATOM   2202 C  CG  . TYR   A 1 329 ? -5.527  -11.345 11.038  1.00 32.63  ? 495 TYR   A CG  1 
ATOM   2203 C  CD1 . TYR   A 1 329 ? -6.066  -12.006 12.142  1.00 33.20  ? 495 TYR   A CD1 1 
ATOM   2204 C  CD2 . TYR   A 1 329 ? -4.149  -11.380 10.863  1.00 33.62  ? 495 TYR   A CD2 1 
ATOM   2205 C  CE1 . TYR   A 1 329 ? -5.258  -12.681 13.041  1.00 39.81  ? 495 TYR   A CE1 1 
ATOM   2206 C  CE2 . TYR   A 1 329 ? -3.328  -12.055 11.761  1.00 40.39  ? 495 TYR   A CE2 1 
ATOM   2207 C  CZ  . TYR   A 1 329 ? -3.889  -12.702 12.848  1.00 44.52  ? 495 TYR   A CZ  1 
ATOM   2208 O  OH  . TYR   A 1 329 ? -3.081  -13.366 13.743  1.00 32.03  ? 495 TYR   A OH  1 
ATOM   2209 N  N   . LEU   A 1 330 ? -5.505  -7.678  10.597  1.00 27.64  ? 496 LEU   A N   1 
ATOM   2210 C  CA  . LEU   A 1 330 ? -4.609  -6.662  11.133  1.00 33.14  ? 496 LEU   A CA  1 
ATOM   2211 C  C   . LEU   A 1 330 ? -4.976  -5.319  10.521  1.00 33.89  ? 496 LEU   A C   1 
ATOM   2212 O  O   . LEU   A 1 330 ? -5.211  -5.228  9.310   1.00 30.53  ? 496 LEU   A O   1 
ATOM   2213 C  CB  . LEU   A 1 330 ? -3.143  -6.996  10.834  1.00 34.58  ? 496 LEU   A CB  1 
ATOM   2214 C  CG  . LEU   A 1 330 ? -2.494  -8.097  11.675  1.00 32.69  ? 496 LEU   A CG  1 
ATOM   2215 C  CD1 . LEU   A 1 330 ? -1.150  -8.473  11.100  1.00 27.78  ? 496 LEU   A CD1 1 
ATOM   2216 C  CD2 . LEU   A 1 330 ? -2.359  -7.645  13.118  1.00 41.25  ? 496 LEU   A CD2 1 
ATOM   2217 N  N   . LEU   A 1 331 ? -5.029  -4.283  11.353  1.00 31.45  ? 497 LEU   A N   1 
ATOM   2218 C  CA  . LEU   A 1 331 ? -5.377  -2.936  10.911  1.00 36.21  ? 497 LEU   A CA  1 
ATOM   2219 C  C   . LEU   A 1 331 ? -4.210  -2.013  11.228  1.00 33.40  ? 497 LEU   A C   1 
ATOM   2220 O  O   . LEU   A 1 331 ? -3.808  -1.890  12.391  1.00 34.27  ? 497 LEU   A O   1 
ATOM   2221 C  CB  . LEU   A 1 331 ? -6.664  -2.446  11.581  1.00 26.40  ? 497 LEU   A CB  1 
ATOM   2222 C  CG  . LEU   A 1 331 ? -7.925  -3.255  11.257  1.00 29.71  ? 497 LEU   A CG  1 
ATOM   2223 C  CD1 . LEU   A 1 331 ? -8.825  -3.426  12.482  1.00 33.07  ? 497 LEU   A CD1 1 
ATOM   2224 C  CD2 . LEU   A 1 331 ? -8.698  -2.625  10.114  1.00 27.86  ? 497 LEU   A CD2 1 
ATOM   2225 N  N   . PHE   A 1 332 ? -3.651  -1.388  10.198  1.00 24.90  ? 498 PHE   A N   1 
ATOM   2226 C  CA  . PHE   A 1 332 ? -2.537  -0.467  10.369  1.00 31.91  ? 498 PHE   A CA  1 
ATOM   2227 C  C   . PHE   A 1 332 ? -3.051  0.952   10.177  1.00 37.33  ? 498 PHE   A C   1 
ATOM   2228 O  O   . PHE   A 1 332 ? -3.596  1.289   9.119   1.00 34.55  ? 498 PHE   A O   1 
ATOM   2229 C  CB  . PHE   A 1 332 ? -1.395  -0.770  9.400   1.00 22.89  ? 498 PHE   A CB  1 
ATOM   2230 C  CG  . PHE   A 1 332 ? -0.681  -2.052  9.698   1.00 34.37  ? 498 PHE   A CG  1 
ATOM   2231 C  CD1 . PHE   A 1 332 ? 0.187   -2.152  10.775  1.00 38.92  ? 498 PHE   A CD1 1 
ATOM   2232 C  CD2 . PHE   A 1 332 ? -0.882  -3.167  8.900   1.00 36.48  ? 498 PHE   A CD2 1 
ATOM   2233 C  CE1 . PHE   A 1 332 ? 0.841   -3.348  11.045  1.00 37.58  ? 498 PHE   A CE1 1 
ATOM   2234 C  CE2 . PHE   A 1 332 ? -0.233  -4.355  9.165   1.00 31.09  ? 498 PHE   A CE2 1 
ATOM   2235 C  CZ  . PHE   A 1 332 ? 0.626   -4.447  10.238  1.00 29.61  ? 498 PHE   A CZ  1 
ATOM   2236 N  N   . TYR   A 1 333 ? -2.903  1.767   11.209  1.00 31.87  ? 499 TYR   A N   1 
ATOM   2237 C  CA  . TYR   A 1 333 ? -3.349  3.145   11.179  1.00 34.21  ? 499 TYR   A CA  1 
ATOM   2238 C  C   . TYR   A 1 333 ? -2.142  4.056   11.321  1.00 39.25  ? 499 TYR   A C   1 
ATOM   2239 O  O   . TYR   A 1 333 ? -1.044  3.632   11.691  1.00 40.27  ? 499 TYR   A O   1 
ATOM   2240 C  CB  . TYR   A 1 333 ? -4.357  3.427   12.299  1.00 31.54  ? 499 TYR   A CB  1 
ATOM   2241 C  CG  . TYR   A 1 333 ? -5.724  2.778   12.165  1.00 26.06  ? 499 TYR   A CG  1 
ATOM   2242 C  CD1 . TYR   A 1 333 ? -6.747  3.410   11.469  1.00 34.54  ? 499 TYR   A CD1 1 
ATOM   2243 C  CD2 . TYR   A 1 333 ? -6.011  1.564   12.788  1.00 27.19  ? 499 TYR   A CD2 1 
ATOM   2244 C  CE1 . TYR   A 1 333 ? -8.009  2.836   11.365  1.00 37.04  ? 499 TYR   A CE1 1 
ATOM   2245 C  CE2 . TYR   A 1 333 ? -7.275  0.983   12.695  1.00 26.98  ? 499 TYR   A CE2 1 
ATOM   2246 C  CZ  . TYR   A 1 333 ? -8.264  1.627   11.979  1.00 37.24  ? 499 TYR   A CZ  1 
ATOM   2247 O  OH  . TYR   A 1 333 ? -9.515  1.075   11.866  1.00 32.50  ? 499 TYR   A OH  1 
ATOM   2248 N  N   . GLU   A 1 334 ? -2.357  5.329   11.026  1.00 35.89  ? 500 GLU   A N   1 
ATOM   2249 C  CA  . GLU   A 1 334 ? -1.316  6.320   11.219  1.00 29.86  ? 500 GLU   A CA  1 
ATOM   2250 C  C   . GLU   A 1 334 ? -1.956  7.561   11.813  1.00 26.88  ? 500 GLU   A C   1 
ATOM   2251 O  O   . GLU   A 1 334 ? -3.059  7.939   11.414  1.00 23.64  ? 500 GLU   A O   1 
ATOM   2252 C  CB  . GLU   A 1 334 ? -0.607  6.613   9.899   1.00 32.21  ? 500 GLU   A CB  1 
ATOM   2253 C  CG  . GLU   A 1 334 ? 0.507   7.633   10.007  1.00 45.79  ? 500 GLU   A CG  1 
ATOM   2254 C  CD  . GLU   A 1 334 ? 1.830   7.160   9.417   1.00 48.91  ? 500 GLU   A CD  1 
ATOM   2255 O  OE1 . GLU   A 1 334 ? 2.167   5.956   9.533   1.00 52.80  ? 500 GLU   A OE1 1 
ATOM   2256 O  OE2 . GLU   A 1 334 ? 2.527   8.008   8.822   1.00 52.60  ? 500 GLU   A OE2 1 
ATOM   2257 N  N   . ARG   A 1 335 ? -1.297  8.144   12.810  1.00 32.79  ? 501 ARG   A N   1 
ATOM   2258 C  CA  . ARG   A 1 335 ? -1.802  9.351   13.454  1.00 39.38  ? 501 ARG   A CA  1 
ATOM   2259 C  C   . ARG   A 1 335 ? -1.758  10.514  12.472  1.00 41.35  ? 501 ARG   A C   1 
ATOM   2260 O  O   . ARG   A 1 335 ? -0.703  10.816  11.907  1.00 43.77  ? 501 ARG   A O   1 
ATOM   2261 C  CB  . ARG   A 1 335 ? -0.981  9.676   14.703  1.00 42.34  ? 501 ARG   A CB  1 
ATOM   2262 C  CG  . ARG   A 1 335 ? -1.357  10.987  15.395  1.00 36.94  ? 501 ARG   A CG  1 
ATOM   2263 C  CD  . ARG   A 1 335 ? -2.501  10.787  16.373  1.00 44.23  ? 501 ARG   A CD  1 
ATOM   2264 N  NE  . ARG   A 1 335 ? -3.159  12.039  16.754  1.00 64.72  ? 501 ARG   A NE  1 
ATOM   2265 C  CZ  . ARG   A 1 335 ? -2.995  12.652  17.925  1.00 70.53  ? 501 ARG   A CZ  1 
ATOM   2266 N  NH1 . ARG   A 1 335 ? -2.186  12.131  18.843  1.00 59.87  ? 501 ARG   A NH1 1 
ATOM   2267 N  NH2 . ARG   A 1 335 ? -3.642  13.786  18.176  1.00 63.82  ? 501 ARG   A NH2 1 
ATOM   2268 N  N   . VAL   A 1 336 ? -2.900  11.164  12.274  1.00 36.92  ? 502 VAL   A N   1 
ATOM   2269 C  CA  . VAL   A 1 336 ? -2.996  12.307  11.381  1.00 47.28  ? 502 VAL   A CA  1 
ATOM   2270 C  C   . VAL   A 1 336 ? -2.340  13.522  12.025  1.00 65.42  ? 502 VAL   A C   1 
ATOM   2271 O  O   . VAL   A 1 336 ? -2.457  13.713  13.236  1.00 70.15  ? 502 VAL   A O   1 
ATOM   2272 C  CB  . VAL   A 1 336 ? -4.458  12.610  11.026  1.00 44.45  ? 502 VAL   A CB  1 
ATOM   2273 C  CG1 . VAL   A 1 336 ? -4.537  13.786  10.067  1.00 43.60  ? 502 VAL   A CG1 1 
ATOM   2274 C  CG2 . VAL   A 1 336 ? -5.122  11.376  10.443  1.00 41.86  ? 502 VAL   A CG2 1 
ATOM   2275 O  OXT . VAL   A 1 336 ? -1.688  14.337  11.365  1.00 75.79  ? 502 VAL   A OXT 1 
HETATM 2276 C  C02 . A1L7W B 2 .   ? -2.670  -20.794 7.006   1.00 51.83  ? 601 A1L7W A C02 1 
HETATM 2277 C  C04 . A1L7W B 2 .   ? -1.678  -22.255 5.107   1.00 55.39  ? 601 A1L7W A C04 1 
HETATM 2278 C  C05 . A1L7W B 2 .   ? -1.808  -21.360 3.854   1.00 61.41  ? 601 A1L7W A C05 1 
HETATM 2279 C  C06 . A1L7W B 2 .   ? -1.351  -22.015 2.796   1.00 50.41  ? 601 A1L7W A C06 1 
HETATM 2280 C  C07 . A1L7W B 2 .   ? 0.098   -21.308 2.417   1.00 40.79  ? 601 A1L7W A C07 1 
HETATM 2281 C  C09 . A1L7W B 2 .   ? 0.303   -18.764 2.073   1.00 47.06  ? 601 A1L7W A C09 1 
HETATM 2282 C  C18 . A1L7W B 2 .   ? -0.853  -20.072 4.072   1.00 49.66  ? 601 A1L7W A C18 1 
HETATM 2283 C  C19 . A1L7W B 2 .   ? -2.499  -20.069 8.311   1.00 51.03  ? 601 A1L7W A C19 1 
HETATM 2284 C  C22 . A1L7W B 2 .   ? -2.917  -18.864 10.082  1.00 39.94  ? 601 A1L7W A C22 1 
HETATM 2285 C  C23 . A1L7W B 2 .   ? -3.635  -17.933 11.092  1.00 46.98  ? 601 A1L7W A C23 1 
HETATM 2286 C  C24 . A1L7W B 2 .   ? -4.763  -17.220 10.708  1.00 48.53  ? 601 A1L7W A C24 1 
HETATM 2287 C  C25 . A1L7W B 2 .   ? -5.394  -16.381 11.620  1.00 48.22  ? 601 A1L7W A C25 1 
HETATM 2288 C  C26 . A1L7W B 2 .   ? -6.670  -15.564 11.208  1.00 42.92  ? 601 A1L7W A C26 1 
HETATM 2289 C  C28 . A1L7W B 2 .   ? -4.904  -16.259 12.887  1.00 49.83  ? 601 A1L7W A C28 1 
HETATM 2290 C  C29 . A1L7W B 2 .   ? -3.770  -16.980 13.272  1.00 37.86  ? 601 A1L7W A C29 1 
HETATM 2291 C  C30 . A1L7W B 2 .   ? -3.145  -17.812 12.367  1.00 37.53  ? 601 A1L7W A C30 1 
HETATM 2292 N  N03 . A1L7W B 2 .   ? -1.503  -21.484 6.379   1.00 49.20  ? 601 A1L7W A N03 1 
HETATM 2293 N  N08 . A1L7W B 2 .   ? -0.092  -20.026 2.776   1.00 53.49  ? 601 A1L7W A N08 1 
HETATM 2294 N  N17 . A1L7W B 2 .   ? 0.946   -18.791 0.966   1.00 47.17  ? 601 A1L7W A N17 1 
HETATM 2295 N  N20 . A1L7W B 2 .   ? -1.430  -20.119 9.093   1.00 52.51  ? 601 A1L7W A N20 1 
HETATM 2296 N  N21 . A1L7W B 2 .   ? -1.689  -19.347 10.205  1.00 48.94  ? 601 A1L7W A N21 1 
HETATM 2297 N  N27 . A1L7W B 2 .   ? -7.601  -14.966 10.918  1.00 45.69  ? 601 A1L7W A N27 1 
HETATM 2298 O  O01 . A1L7W B 2 .   ? -3.723  -20.852 6.496   1.00 54.31  ? 601 A1L7W A O01 1 
HETATM 2299 O  O31 . A1L7W B 2 .   ? -3.406  -19.308 8.927   1.00 43.47  ? 601 A1L7W A O31 1 
HETATM 2300 ZN ZN  . ZN    C 3 .   ? -13.295 -9.623  45.355  1.00 39.76  ? 602 ZN    A ZN  1 
HETATM 2301 O  O   . HOH   D 4 .   ? -11.730 -6.224  22.918  1.00 41.67  ? 701 HOH   A O   1 
HETATM 2302 O  O   . HOH   D 4 .   ? 0.767   -0.437  17.510  1.00 32.62  ? 702 HOH   A O   1 
HETATM 2303 O  O   . HOH   D 4 .   ? -14.052 -6.760  9.455   1.00 29.57  ? 703 HOH   A O   1 
HETATM 2304 O  O   . HOH   D 4 .   ? 6.705   4.881   19.647  1.00 29.18  ? 704 HOH   A O   1 
HETATM 2305 O  O   . HOH   D 4 .   ? -10.841 6.301   -0.878  1.00 36.58  ? 705 HOH   A O   1 
HETATM 2306 O  O   . HOH   D 4 .   ? -12.923 -10.564 4.176   1.00 30.72  ? 706 HOH   A O   1 
HETATM 2307 O  O   . HOH   D 4 .   ? -0.820  7.505   0.240   1.00 36.69  ? 707 HOH   A O   1 
HETATM 2308 O  O   . HOH   D 4 .   ? 0.482   -9.703  -0.910  1.00 35.62  ? 708 HOH   A O   1 
HETATM 2309 O  O   . HOH   D 4 .   ? -16.065 -2.007  7.991   1.00 25.07  ? 709 HOH   A O   1 
HETATM 2310 O  O   . HOH   D 4 .   ? 5.725   6.891   -2.267  1.00 46.44  ? 710 HOH   A O   1 
HETATM 2311 O  O   . HOH   D 4 .   ? -8.884  -2.055  46.164  1.00 50.42  ? 711 HOH   A O   1 
HETATM 2312 O  O   . HOH   D 4 .   ? 5.326   6.879   18.042  1.00 23.07  ? 712 HOH   A O   1 
HETATM 2313 O  O   . HOH   D 4 .   ? -5.820  -14.588 15.846  1.00 40.55  ? 713 HOH   A O   1 
HETATM 2314 O  O   . HOH   D 4 .   ? -11.042 -13.296 20.840  1.00 38.36  ? 714 HOH   A O   1 
HETATM 2315 O  O   . HOH   D 4 .   ? -16.326 0.878   14.213  1.00 42.37  ? 715 HOH   A O   1 
HETATM 2316 O  O   . HOH   D 4 .   ? -7.500  12.311  -5.005  1.00 49.05  ? 716 HOH   A O   1 
# 
