data_9LSM
# 
_entry.id   9LSM 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9LSM         pdb_00009lsm 10.2210/pdb9lsm/pdb 
WWPDB D_1300056367 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-18 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9LSM 
_pdbx_database_status.recvd_initial_deposition_date   2025-02-04 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              hbluo@hainanu.edu.cn 
_pdbx_contact_author.name_first         Hai-Bin 
_pdbx_contact_author.name_last          Luo 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-2163-0509 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Wu, D.'       1 ? 
'Huang, Y.-Y.' 2 ? 
'Luo, H.-B.'   3 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   CC 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Chin.Chem.Lett. 
_citation.journal_id_ASTM           CCLEE7 
_citation.journal_id_CSD            1182 
_citation.journal_id_ISSN           1001-8417 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                111236 
_citation.page_last                 ? 
_citation.title                     
'Plasma metabolites-based drug design: Discovery of novel and highly selective phosphodiesterase 5 inhibitors' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.cclet.2025.111236 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Wu, D.'      1  ? 
primary 'Ma, Q.'      2  ? 
primary 'Chen, Y.'    3  ? 
primary 'Yang, G.'    4  ? 
primary 'Zhang, F.'   5  ? 
primary 'Jiang, M.'   6  ? 
primary 'Wang, X.'    7  ? 
primary 'Liu, X.'     8  ? 
primary 'Zhou, Q.'    9  ? 
primary 'Huang, Y.Y.' 10 ? 
primary 'Li, Z.'      11 ? 
primary 'Luo, H.B.'   12 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 
;cGMP-specific 3',5'-cyclic phosphodiesterase
;
37788.531 1  3.1.4.35 ? ? ? 
2 non-polymer syn 
;1-[(13~{S},15~{R})-4-bromanyl-15-(3-chloranyl-4-methoxy-phenyl)-8,12,16-triazatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(17),2,4,6,8-pentaen-12-yl]ethanone
;
486.789   1  ?        ? ? ? 
3 non-polymer syn 'ZINC ION' 65.409    1  ?        ? ? ? 
4 non-polymer syn 'MAGNESIUM ION' 24.305    1  ?        ? ? ? 
5 non-polymer syn 'SULFATE ION' 96.063    1  ?        ? ? ? 
6 water       nat water 18.015    25 ?        ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'cGMP-binding cGMP-specific phosphodiesterase,CGB-PDE' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;EETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHN
WRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILN
SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPI
QQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQ
ALAEQQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;EETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHN
WRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILN
SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPI
QQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQ
ALAEQQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 
;1-[(13~{S},15~{R})-4-bromanyl-15-(3-chloranyl-4-methoxy-phenyl)-8,12,16-triazatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(17),2,4,6,8-pentaen-12-yl]ethanone
;
A1ELC 
3 'ZINC ION' ZN    
4 'MAGNESIUM ION' MG    
5 'SULFATE ION' SO4   
6 water HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLU n 
1 2   GLU n 
1 3   THR n 
1 4   ARG n 
1 5   GLU n 
1 6   LEU n 
1 7   GLN n 
1 8   SER n 
1 9   LEU n 
1 10  ALA n 
1 11  ALA n 
1 12  ALA n 
1 13  VAL n 
1 14  VAL n 
1 15  PRO n 
1 16  SER n 
1 17  ALA n 
1 18  GLN n 
1 19  THR n 
1 20  LEU n 
1 21  LYS n 
1 22  ILE n 
1 23  THR n 
1 24  ASP n 
1 25  PHE n 
1 26  SER n 
1 27  PHE n 
1 28  SER n 
1 29  ASP n 
1 30  PHE n 
1 31  GLU n 
1 32  LEU n 
1 33  SER n 
1 34  ASP n 
1 35  LEU n 
1 36  GLU n 
1 37  THR n 
1 38  ALA n 
1 39  LEU n 
1 40  CYS n 
1 41  THR n 
1 42  ILE n 
1 43  ARG n 
1 44  MET n 
1 45  PHE n 
1 46  THR n 
1 47  ASP n 
1 48  LEU n 
1 49  ASN n 
1 50  LEU n 
1 51  VAL n 
1 52  GLN n 
1 53  ASN n 
1 54  PHE n 
1 55  GLN n 
1 56  MET n 
1 57  LYS n 
1 58  HIS n 
1 59  GLU n 
1 60  VAL n 
1 61  LEU n 
1 62  CYS n 
1 63  ARG n 
1 64  TRP n 
1 65  ILE n 
1 66  LEU n 
1 67  SER n 
1 68  VAL n 
1 69  LYS n 
1 70  LYS n 
1 71  ASN n 
1 72  TYR n 
1 73  ARG n 
1 74  LYS n 
1 75  ASN n 
1 76  VAL n 
1 77  ALA n 
1 78  TYR n 
1 79  HIS n 
1 80  ASN n 
1 81  TRP n 
1 82  ARG n 
1 83  HIS n 
1 84  ALA n 
1 85  PHE n 
1 86  ASN n 
1 87  THR n 
1 88  ALA n 
1 89  GLN n 
1 90  CYS n 
1 91  MET n 
1 92  PHE n 
1 93  ALA n 
1 94  ALA n 
1 95  LEU n 
1 96  LYS n 
1 97  ALA n 
1 98  GLY n 
1 99  LYS n 
1 100 ILE n 
1 101 GLN n 
1 102 ASN n 
1 103 LYS n 
1 104 LEU n 
1 105 THR n 
1 106 ASP n 
1 107 LEU n 
1 108 GLU n 
1 109 ILE n 
1 110 LEU n 
1 111 ALA n 
1 112 LEU n 
1 113 LEU n 
1 114 ILE n 
1 115 ALA n 
1 116 ALA n 
1 117 LEU n 
1 118 SER n 
1 119 HIS n 
1 120 ASP n 
1 121 LEU n 
1 122 ASP n 
1 123 HIS n 
1 124 ARG n 
1 125 GLY n 
1 126 VAL n 
1 127 ASN n 
1 128 ASN n 
1 129 SER n 
1 130 TYR n 
1 131 ILE n 
1 132 GLN n 
1 133 ARG n 
1 134 SER n 
1 135 GLU n 
1 136 HIS n 
1 137 PRO n 
1 138 LEU n 
1 139 ALA n 
1 140 GLN n 
1 141 LEU n 
1 142 TYR n 
1 143 CYS n 
1 144 HIS n 
1 145 SER n 
1 146 ILE n 
1 147 MET n 
1 148 GLU n 
1 149 HIS n 
1 150 HIS n 
1 151 HIS n 
1 152 PHE n 
1 153 ASP n 
1 154 GLN n 
1 155 CYS n 
1 156 LEU n 
1 157 MET n 
1 158 ILE n 
1 159 LEU n 
1 160 ASN n 
1 161 SER n 
1 162 PRO n 
1 163 GLY n 
1 164 ASN n 
1 165 GLN n 
1 166 ILE n 
1 167 LEU n 
1 168 SER n 
1 169 GLY n 
1 170 LEU n 
1 171 SER n 
1 172 ILE n 
1 173 GLU n 
1 174 GLU n 
1 175 TYR n 
1 176 LYS n 
1 177 THR n 
1 178 THR n 
1 179 LEU n 
1 180 LYS n 
1 181 ILE n 
1 182 ILE n 
1 183 LYS n 
1 184 GLN n 
1 185 ALA n 
1 186 ILE n 
1 187 LEU n 
1 188 ALA n 
1 189 THR n 
1 190 ASP n 
1 191 LEU n 
1 192 ALA n 
1 193 LEU n 
1 194 TYR n 
1 195 ILE n 
1 196 LYS n 
1 197 ARG n 
1 198 ARG n 
1 199 GLY n 
1 200 GLU n 
1 201 PHE n 
1 202 PHE n 
1 203 GLU n 
1 204 LEU n 
1 205 ILE n 
1 206 ARG n 
1 207 LYS n 
1 208 ASN n 
1 209 GLN n 
1 210 PHE n 
1 211 ASN n 
1 212 LEU n 
1 213 GLU n 
1 214 ASP n 
1 215 PRO n 
1 216 HIS n 
1 217 GLN n 
1 218 LYS n 
1 219 GLU n 
1 220 LEU n 
1 221 PHE n 
1 222 LEU n 
1 223 ALA n 
1 224 MET n 
1 225 LEU n 
1 226 MET n 
1 227 THR n 
1 228 ALA n 
1 229 CYS n 
1 230 ASP n 
1 231 LEU n 
1 232 SER n 
1 233 ALA n 
1 234 ILE n 
1 235 THR n 
1 236 LYS n 
1 237 PRO n 
1 238 TRP n 
1 239 PRO n 
1 240 ILE n 
1 241 GLN n 
1 242 GLN n 
1 243 ARG n 
1 244 ILE n 
1 245 ALA n 
1 246 GLU n 
1 247 LEU n 
1 248 VAL n 
1 249 ALA n 
1 250 THR n 
1 251 GLU n 
1 252 PHE n 
1 253 PHE n 
1 254 ASP n 
1 255 GLN n 
1 256 GLY n 
1 257 ASP n 
1 258 ARG n 
1 259 GLU n 
1 260 ARG n 
1 261 LYS n 
1 262 GLU n 
1 263 LEU n 
1 264 ASN n 
1 265 ILE n 
1 266 GLU n 
1 267 PRO n 
1 268 THR n 
1 269 ASP n 
1 270 LEU n 
1 271 MET n 
1 272 ASN n 
1 273 ARG n 
1 274 GLU n 
1 275 LYS n 
1 276 LYS n 
1 277 ASN n 
1 278 LYS n 
1 279 ILE n 
1 280 PRO n 
1 281 SER n 
1 282 MET n 
1 283 GLN n 
1 284 VAL n 
1 285 GLY n 
1 286 PHE n 
1 287 ILE n 
1 288 ASP n 
1 289 ALA n 
1 290 ILE n 
1 291 CYS n 
1 292 LEU n 
1 293 GLN n 
1 294 LEU n 
1 295 TYR n 
1 296 GLU n 
1 297 ALA n 
1 298 LEU n 
1 299 THR n 
1 300 HIS n 
1 301 VAL n 
1 302 SER n 
1 303 GLU n 
1 304 ASP n 
1 305 CYS n 
1 306 PHE n 
1 307 PRO n 
1 308 LEU n 
1 309 LEU n 
1 310 ASP n 
1 311 GLY n 
1 312 CYS n 
1 313 ARG n 
1 314 LYS n 
1 315 ASN n 
1 316 ARG n 
1 317 GLN n 
1 318 LYS n 
1 319 TRP n 
1 320 GLN n 
1 321 ALA n 
1 322 LEU n 
1 323 ALA n 
1 324 GLU n 
1 325 GLN n 
1 326 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   326 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'PDE5A, PDE5' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     511693 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1ELC non-polymer         . 
;1-[(13~{S},15~{R})-4-bromanyl-15-(3-chloranyl-4-methoxy-phenyl)-8,12,16-triazatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(17),2,4,6,8-pentaen-12-yl]ethanone
;
? 'C23 H21 Br Cl N3 O2' 486.789 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'          89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'      175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'         132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'          133.103 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'        121.158 
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'        146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'          147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'          75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'      156.162 
HOH   non-polymer         . WATER ? 'H2 O'                18.015  
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'         131.173 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'         131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'      147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'       149.211 
MG    non-polymer         . 'MAGNESIUM ION' ? 'Mg 2'                24.305  
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'         165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'          115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'          105.093 
SO4   non-polymer         . 'SULFATE ION' ? 'O4 S -2'             96.063  
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'          119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'       204.225 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'         181.189 
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'         117.146 
ZN    non-polymer         . 'ZINC ION' ? 'Zn 2'                65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLU 1   535 ?   ?   ?   A . n 
A 1 2   GLU 2   536 ?   ?   ?   A . n 
A 1 3   THR 3   537 537 THR THR A . n 
A 1 4   ARG 4   538 538 ARG ARG A . n 
A 1 5   GLU 5   539 539 GLU GLU A . n 
A 1 6   LEU 6   540 540 LEU LEU A . n 
A 1 7   GLN 7   541 541 GLN GLN A . n 
A 1 8   SER 8   542 542 SER SER A . n 
A 1 9   LEU 9   543 543 LEU LEU A . n 
A 1 10  ALA 10  544 544 ALA ALA A . n 
A 1 11  ALA 11  545 545 ALA ALA A . n 
A 1 12  ALA 12  546 546 ALA ALA A . n 
A 1 13  VAL 13  547 547 VAL VAL A . n 
A 1 14  VAL 14  548 548 VAL VAL A . n 
A 1 15  PRO 15  549 549 PRO PRO A . n 
A 1 16  SER 16  550 550 SER SER A . n 
A 1 17  ALA 17  551 551 ALA ALA A . n 
A 1 18  GLN 18  552 552 GLN GLN A . n 
A 1 19  THR 19  553 553 THR THR A . n 
A 1 20  LEU 20  554 554 LEU LEU A . n 
A 1 21  LYS 21  555 555 LYS LYS A . n 
A 1 22  ILE 22  556 556 ILE ILE A . n 
A 1 23  THR 23  557 557 THR THR A . n 
A 1 24  ASP 24  558 558 ASP ASP A . n 
A 1 25  PHE 25  559 559 PHE PHE A . n 
A 1 26  SER 26  560 560 SER SER A . n 
A 1 27  PHE 27  561 561 PHE PHE A . n 
A 1 28  SER 28  562 562 SER SER A . n 
A 1 29  ASP 29  563 563 ASP ASP A . n 
A 1 30  PHE 30  564 564 PHE PHE A . n 
A 1 31  GLU 31  565 565 GLU GLU A . n 
A 1 32  LEU 32  566 566 LEU LEU A . n 
A 1 33  SER 33  567 567 SER SER A . n 
A 1 34  ASP 34  568 568 ASP ASP A . n 
A 1 35  LEU 35  569 569 LEU LEU A . n 
A 1 36  GLU 36  570 570 GLU GLU A . n 
A 1 37  THR 37  571 571 THR THR A . n 
A 1 38  ALA 38  572 572 ALA ALA A . n 
A 1 39  LEU 39  573 573 LEU LEU A . n 
A 1 40  CYS 40  574 574 CYS CYS A . n 
A 1 41  THR 41  575 575 THR THR A . n 
A 1 42  ILE 42  576 576 ILE ILE A . n 
A 1 43  ARG 43  577 577 ARG ARG A . n 
A 1 44  MET 44  578 578 MET MET A . n 
A 1 45  PHE 45  579 579 PHE PHE A . n 
A 1 46  THR 46  580 580 THR THR A . n 
A 1 47  ASP 47  581 581 ASP ASP A . n 
A 1 48  LEU 48  582 582 LEU LEU A . n 
A 1 49  ASN 49  583 583 ASN ASN A . n 
A 1 50  LEU 50  584 584 LEU LEU A . n 
A 1 51  VAL 51  585 585 VAL VAL A . n 
A 1 52  GLN 52  586 586 GLN GLN A . n 
A 1 53  ASN 53  587 587 ASN ASN A . n 
A 1 54  PHE 54  588 588 PHE PHE A . n 
A 1 55  GLN 55  589 589 GLN GLN A . n 
A 1 56  MET 56  590 590 MET MET A . n 
A 1 57  LYS 57  591 591 LYS LYS A . n 
A 1 58  HIS 58  592 592 HIS HIS A . n 
A 1 59  GLU 59  593 593 GLU GLU A . n 
A 1 60  VAL 60  594 594 VAL VAL A . n 
A 1 61  LEU 61  595 595 LEU LEU A . n 
A 1 62  CYS 62  596 596 CYS CYS A . n 
A 1 63  ARG 63  597 597 ARG ARG A . n 
A 1 64  TRP 64  598 598 TRP TRP A . n 
A 1 65  ILE 65  599 599 ILE ILE A . n 
A 1 66  LEU 66  600 600 LEU LEU A . n 
A 1 67  SER 67  601 601 SER SER A . n 
A 1 68  VAL 68  602 602 VAL VAL A . n 
A 1 69  LYS 69  603 603 LYS LYS A . n 
A 1 70  LYS 70  604 604 LYS LYS A . n 
A 1 71  ASN 71  605 605 ASN ASN A . n 
A 1 72  TYR 72  606 606 TYR TYR A . n 
A 1 73  ARG 73  607 607 ARG ARG A . n 
A 1 74  LYS 74  608 608 LYS LYS A . n 
A 1 75  ASN 75  609 609 ASN ASN A . n 
A 1 76  VAL 76  610 610 VAL VAL A . n 
A 1 77  ALA 77  611 611 ALA ALA A . n 
A 1 78  TYR 78  612 612 TYR TYR A . n 
A 1 79  HIS 79  613 613 HIS HIS A . n 
A 1 80  ASN 80  614 614 ASN ASN A . n 
A 1 81  TRP 81  615 615 TRP TRP A . n 
A 1 82  ARG 82  616 616 ARG ARG A . n 
A 1 83  HIS 83  617 617 HIS HIS A . n 
A 1 84  ALA 84  618 618 ALA ALA A . n 
A 1 85  PHE 85  619 619 PHE PHE A . n 
A 1 86  ASN 86  620 620 ASN ASN A . n 
A 1 87  THR 87  621 621 THR THR A . n 
A 1 88  ALA 88  622 622 ALA ALA A . n 
A 1 89  GLN 89  623 623 GLN GLN A . n 
A 1 90  CYS 90  624 624 CYS CYS A . n 
A 1 91  MET 91  625 625 MET MET A . n 
A 1 92  PHE 92  626 626 PHE PHE A . n 
A 1 93  ALA 93  627 627 ALA ALA A . n 
A 1 94  ALA 94  628 628 ALA ALA A . n 
A 1 95  LEU 95  629 629 LEU LEU A . n 
A 1 96  LYS 96  630 630 LYS LYS A . n 
A 1 97  ALA 97  631 631 ALA ALA A . n 
A 1 98  GLY 98  632 632 GLY GLY A . n 
A 1 99  LYS 99  633 633 LYS LYS A . n 
A 1 100 ILE 100 634 634 ILE ILE A . n 
A 1 101 GLN 101 635 635 GLN GLN A . n 
A 1 102 ASN 102 636 636 ASN ASN A . n 
A 1 103 LYS 103 637 637 LYS LYS A . n 
A 1 104 LEU 104 638 638 LEU LEU A . n 
A 1 105 THR 105 639 639 THR THR A . n 
A 1 106 ASP 106 640 640 ASP ASP A . n 
A 1 107 LEU 107 641 641 LEU LEU A . n 
A 1 108 GLU 108 642 642 GLU GLU A . n 
A 1 109 ILE 109 643 643 ILE ILE A . n 
A 1 110 LEU 110 644 644 LEU LEU A . n 
A 1 111 ALA 111 645 645 ALA ALA A . n 
A 1 112 LEU 112 646 646 LEU LEU A . n 
A 1 113 LEU 113 647 647 LEU LEU A . n 
A 1 114 ILE 114 648 648 ILE ILE A . n 
A 1 115 ALA 115 649 649 ALA ALA A . n 
A 1 116 ALA 116 650 650 ALA ALA A . n 
A 1 117 LEU 117 651 651 LEU LEU A . n 
A 1 118 SER 118 652 652 SER SER A . n 
A 1 119 HIS 119 653 653 HIS HIS A . n 
A 1 120 ASP 120 654 654 ASP ASP A . n 
A 1 121 LEU 121 655 655 LEU LEU A . n 
A 1 122 ASP 122 656 656 ASP ASP A . n 
A 1 123 HIS 123 657 657 HIS HIS A . n 
A 1 124 ARG 124 658 658 ARG ARG A . n 
A 1 125 GLY 125 659 659 GLY GLY A . n 
A 1 126 VAL 126 660 660 VAL VAL A . n 
A 1 127 ASN 127 661 661 ASN ASN A . n 
A 1 128 ASN 128 662 662 ASN ASN A . n 
A 1 129 SER 129 663 ?   ?   ?   A . n 
A 1 130 TYR 130 664 ?   ?   ?   A . n 
A 1 131 ILE 131 665 ?   ?   ?   A . n 
A 1 132 GLN 132 666 ?   ?   ?   A . n 
A 1 133 ARG 133 667 ?   ?   ?   A . n 
A 1 134 SER 134 668 ?   ?   ?   A . n 
A 1 135 GLU 135 669 ?   ?   ?   A . n 
A 1 136 HIS 136 670 ?   ?   ?   A . n 
A 1 137 PRO 137 671 ?   ?   ?   A . n 
A 1 138 LEU 138 672 ?   ?   ?   A . n 
A 1 139 ALA 139 673 ?   ?   ?   A . n 
A 1 140 GLN 140 674 ?   ?   ?   A . n 
A 1 141 LEU 141 675 ?   ?   ?   A . n 
A 1 142 TYR 142 676 ?   ?   ?   A . n 
A 1 143 CYS 143 677 ?   ?   ?   A . n 
A 1 144 HIS 144 678 ?   ?   ?   A . n 
A 1 145 SER 145 679 679 SER SER A . n 
A 1 146 ILE 146 680 680 ILE ILE A . n 
A 1 147 MET 147 681 681 MET MET A . n 
A 1 148 GLU 148 682 682 GLU GLU A . n 
A 1 149 HIS 149 683 683 HIS HIS A . n 
A 1 150 HIS 150 684 684 HIS HIS A . n 
A 1 151 HIS 151 685 685 HIS HIS A . n 
A 1 152 PHE 152 686 686 PHE PHE A . n 
A 1 153 ASP 153 687 687 ASP ASP A . n 
A 1 154 GLN 154 688 688 GLN GLN A . n 
A 1 155 CYS 155 689 689 CYS CYS A . n 
A 1 156 LEU 156 690 690 LEU LEU A . n 
A 1 157 MET 157 691 691 MET MET A . n 
A 1 158 ILE 158 692 692 ILE ILE A . n 
A 1 159 LEU 159 693 693 LEU LEU A . n 
A 1 160 ASN 160 694 694 ASN ASN A . n 
A 1 161 SER 161 695 695 SER SER A . n 
A 1 162 PRO 162 696 696 PRO PRO A . n 
A 1 163 GLY 163 697 697 GLY GLY A . n 
A 1 164 ASN 164 698 698 ASN ASN A . n 
A 1 165 GLN 165 699 699 GLN GLN A . n 
A 1 166 ILE 166 700 700 ILE ILE A . n 
A 1 167 LEU 167 701 701 LEU LEU A . n 
A 1 168 SER 168 702 702 SER SER A . n 
A 1 169 GLY 169 703 703 GLY GLY A . n 
A 1 170 LEU 170 704 704 LEU LEU A . n 
A 1 171 SER 171 705 705 SER SER A . n 
A 1 172 ILE 172 706 706 ILE ILE A . n 
A 1 173 GLU 173 707 707 GLU GLU A . n 
A 1 174 GLU 174 708 708 GLU GLU A . n 
A 1 175 TYR 175 709 709 TYR TYR A . n 
A 1 176 LYS 176 710 710 LYS LYS A . n 
A 1 177 THR 177 711 711 THR THR A . n 
A 1 178 THR 178 712 712 THR THR A . n 
A 1 179 LEU 179 713 713 LEU LEU A . n 
A 1 180 LYS 180 714 714 LYS LYS A . n 
A 1 181 ILE 181 715 715 ILE ILE A . n 
A 1 182 ILE 182 716 716 ILE ILE A . n 
A 1 183 LYS 183 717 717 LYS LYS A . n 
A 1 184 GLN 184 718 718 GLN GLN A . n 
A 1 185 ALA 185 719 719 ALA ALA A . n 
A 1 186 ILE 186 720 720 ILE ILE A . n 
A 1 187 LEU 187 721 721 LEU LEU A . n 
A 1 188 ALA 188 722 722 ALA ALA A . n 
A 1 189 THR 189 723 723 THR THR A . n 
A 1 190 ASP 190 724 724 ASP ASP A . n 
A 1 191 LEU 191 725 725 LEU LEU A . n 
A 1 192 ALA 192 726 726 ALA ALA A . n 
A 1 193 LEU 193 727 727 LEU LEU A . n 
A 1 194 TYR 194 728 728 TYR TYR A . n 
A 1 195 ILE 195 729 729 ILE ILE A . n 
A 1 196 LYS 196 730 730 LYS LYS A . n 
A 1 197 ARG 197 731 731 ARG ARG A . n 
A 1 198 ARG 198 732 732 ARG ARG A . n 
A 1 199 GLY 199 733 733 GLY GLY A . n 
A 1 200 GLU 200 734 734 GLU GLU A . n 
A 1 201 PHE 201 735 735 PHE PHE A . n 
A 1 202 PHE 202 736 736 PHE PHE A . n 
A 1 203 GLU 203 737 737 GLU GLU A . n 
A 1 204 LEU 204 738 738 LEU LEU A . n 
A 1 205 ILE 205 739 739 ILE ILE A . n 
A 1 206 ARG 206 740 740 ARG ARG A . n 
A 1 207 LYS 207 741 741 LYS LYS A . n 
A 1 208 ASN 208 742 742 ASN ASN A . n 
A 1 209 GLN 209 743 743 GLN GLN A . n 
A 1 210 PHE 210 744 744 PHE PHE A . n 
A 1 211 ASN 211 745 745 ASN ASN A . n 
A 1 212 LEU 212 746 746 LEU LEU A . n 
A 1 213 GLU 213 747 747 GLU GLU A . n 
A 1 214 ASP 214 748 748 ASP ASP A . n 
A 1 215 PRO 215 749 749 PRO PRO A . n 
A 1 216 HIS 216 750 750 HIS HIS A . n 
A 1 217 GLN 217 751 751 GLN GLN A . n 
A 1 218 LYS 218 752 752 LYS LYS A . n 
A 1 219 GLU 219 753 753 GLU GLU A . n 
A 1 220 LEU 220 754 754 LEU LEU A . n 
A 1 221 PHE 221 755 755 PHE PHE A . n 
A 1 222 LEU 222 756 756 LEU LEU A . n 
A 1 223 ALA 223 757 757 ALA ALA A . n 
A 1 224 MET 224 758 758 MET MET A . n 
A 1 225 LEU 225 759 759 LEU LEU A . n 
A 1 226 MET 226 760 760 MET MET A . n 
A 1 227 THR 227 761 761 THR THR A . n 
A 1 228 ALA 228 762 762 ALA ALA A . n 
A 1 229 CYS 229 763 763 CYS CYS A . n 
A 1 230 ASP 230 764 764 ASP ASP A . n 
A 1 231 LEU 231 765 765 LEU LEU A . n 
A 1 232 SER 232 766 766 SER SER A . n 
A 1 233 ALA 233 767 767 ALA ALA A . n 
A 1 234 ILE 234 768 768 ILE ILE A . n 
A 1 235 THR 235 769 769 THR THR A . n 
A 1 236 LYS 236 770 770 LYS LYS A . n 
A 1 237 PRO 237 771 771 PRO PRO A . n 
A 1 238 TRP 238 772 772 TRP TRP A . n 
A 1 239 PRO 239 773 773 PRO PRO A . n 
A 1 240 ILE 240 774 774 ILE ILE A . n 
A 1 241 GLN 241 775 775 GLN GLN A . n 
A 1 242 GLN 242 776 776 GLN GLN A . n 
A 1 243 ARG 243 777 777 ARG ARG A . n 
A 1 244 ILE 244 778 778 ILE ILE A . n 
A 1 245 ALA 245 779 779 ALA ALA A . n 
A 1 246 GLU 246 780 780 GLU GLU A . n 
A 1 247 LEU 247 781 781 LEU LEU A . n 
A 1 248 VAL 248 782 782 VAL VAL A . n 
A 1 249 ALA 249 783 783 ALA ALA A . n 
A 1 250 THR 250 784 784 THR THR A . n 
A 1 251 GLU 251 785 785 GLU GLU A . n 
A 1 252 PHE 252 786 786 PHE PHE A . n 
A 1 253 PHE 253 787 787 PHE PHE A . n 
A 1 254 ASP 254 788 788 ASP ASP A . n 
A 1 255 GLN 255 789 789 GLN GLN A . n 
A 1 256 GLY 256 790 ?   ?   ?   A . n 
A 1 257 ASP 257 791 ?   ?   ?   A . n 
A 1 258 ARG 258 792 ?   ?   ?   A . n 
A 1 259 GLU 259 793 ?   ?   ?   A . n 
A 1 260 ARG 260 794 ?   ?   ?   A . n 
A 1 261 LYS 261 795 ?   ?   ?   A . n 
A 1 262 GLU 262 796 ?   ?   ?   A . n 
A 1 263 LEU 263 797 ?   ?   ?   A . n 
A 1 264 ASN 264 798 ?   ?   ?   A . n 
A 1 265 ILE 265 799 ?   ?   ?   A . n 
A 1 266 GLU 266 800 ?   ?   ?   A . n 
A 1 267 PRO 267 801 ?   ?   ?   A . n 
A 1 268 THR 268 802 ?   ?   ?   A . n 
A 1 269 ASP 269 803 ?   ?   ?   A . n 
A 1 270 LEU 270 804 ?   ?   ?   A . n 
A 1 271 MET 271 805 ?   ?   ?   A . n 
A 1 272 ASN 272 806 ?   ?   ?   A . n 
A 1 273 ARG 273 807 ?   ?   ?   A . n 
A 1 274 GLU 274 808 ?   ?   ?   A . n 
A 1 275 LYS 275 809 ?   ?   ?   A . n 
A 1 276 LYS 276 810 ?   ?   ?   A . n 
A 1 277 ASN 277 811 ?   ?   ?   A . n 
A 1 278 LYS 278 812 812 LYS LYS A . n 
A 1 279 ILE 279 813 813 ILE ILE A . n 
A 1 280 PRO 280 814 814 PRO PRO A . n 
A 1 281 SER 281 815 815 SER SER A . n 
A 1 282 MET 282 816 816 MET MET A . n 
A 1 283 GLN 283 817 817 GLN GLN A . n 
A 1 284 VAL 284 818 818 VAL VAL A . n 
A 1 285 GLY 285 819 819 GLY GLY A . n 
A 1 286 PHE 286 820 820 PHE PHE A . n 
A 1 287 ILE 287 821 821 ILE ILE A . n 
A 1 288 ASP 288 822 822 ASP ASP A . n 
A 1 289 ALA 289 823 823 ALA ALA A . n 
A 1 290 ILE 290 824 824 ILE ILE A . n 
A 1 291 CYS 291 825 825 CYS CYS A . n 
A 1 292 LEU 292 826 826 LEU LEU A . n 
A 1 293 GLN 293 827 827 GLN GLN A . n 
A 1 294 LEU 294 828 828 LEU LEU A . n 
A 1 295 TYR 295 829 829 TYR TYR A . n 
A 1 296 GLU 296 830 830 GLU GLU A . n 
A 1 297 ALA 297 831 831 ALA ALA A . n 
A 1 298 LEU 298 832 832 LEU LEU A . n 
A 1 299 THR 299 833 833 THR THR A . n 
A 1 300 HIS 300 834 834 HIS HIS A . n 
A 1 301 VAL 301 835 835 VAL VAL A . n 
A 1 302 SER 302 836 836 SER SER A . n 
A 1 303 GLU 303 837 837 GLU GLU A . n 
A 1 304 ASP 304 838 838 ASP ASP A . n 
A 1 305 CYS 305 839 839 CYS CYS A . n 
A 1 306 PHE 306 840 840 PHE PHE A . n 
A 1 307 PRO 307 841 841 PRO PRO A . n 
A 1 308 LEU 308 842 842 LEU LEU A . n 
A 1 309 LEU 309 843 843 LEU LEU A . n 
A 1 310 ASP 310 844 844 ASP ASP A . n 
A 1 311 GLY 311 845 845 GLY GLY A . n 
A 1 312 CYS 312 846 846 CYS CYS A . n 
A 1 313 ARG 313 847 847 ARG ARG A . n 
A 1 314 LYS 314 848 848 LYS LYS A . n 
A 1 315 ASN 315 849 849 ASN ASN A . n 
A 1 316 ARG 316 850 850 ARG ARG A . n 
A 1 317 GLN 317 851 851 GLN GLN A . n 
A 1 318 LYS 318 852 852 LYS LYS A . n 
A 1 319 TRP 319 853 853 TRP TRP A . n 
A 1 320 GLN 320 854 854 GLN GLN A . n 
A 1 321 ALA 321 855 855 ALA ALA A . n 
A 1 322 LEU 322 856 856 LEU LEU A . n 
A 1 323 ALA 323 857 857 ALA ALA A . n 
A 1 324 GLU 324 858 858 GLU GLU A . n 
A 1 325 GLN 325 859 859 GLN GLN A . n 
A 1 326 GLN 326 860 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1ELC 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1ELC 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 A1ELC 1  901  901 A1ELC YQ1 A . 
C 3 ZN    1  902  1   ZN    ZN  A . 
D 4 MG    1  903  1   MG    MG  A . 
E 5 SO4   1  904  1   SO4   SO4 A . 
F 6 HOH   1  1001 2   HOH   HOH A . 
F 6 HOH   2  1002 1   HOH   HOH A . 
F 6 HOH   3  1003 5   HOH   HOH A . 
F 6 HOH   4  1004 25  HOH   HOH A . 
F 6 HOH   5  1005 19  HOH   HOH A . 
F 6 HOH   6  1006 4   HOH   HOH A . 
F 6 HOH   7  1007 8   HOH   HOH A . 
F 6 HOH   8  1008 14  HOH   HOH A . 
F 6 HOH   9  1009 3   HOH   HOH A . 
F 6 HOH   10 1010 6   HOH   HOH A . 
F 6 HOH   11 1011 21  HOH   HOH A . 
F 6 HOH   12 1012 13  HOH   HOH A . 
F 6 HOH   13 1013 15  HOH   HOH A . 
F 6 HOH   14 1014 7   HOH   HOH A . 
F 6 HOH   15 1015 10  HOH   HOH A . 
F 6 HOH   16 1016 18  HOH   HOH A . 
F 6 HOH   17 1017 11  HOH   HOH A . 
F 6 HOH   18 1018 17  HOH   HOH A . 
F 6 HOH   19 1019 12  HOH   HOH A . 
F 6 HOH   20 1020 9   HOH   HOH A . 
F 6 HOH   21 1021 22  HOH   HOH A . 
F 6 HOH   22 1022 24  HOH   HOH A . 
F 6 HOH   23 1023 23  HOH   HOH A . 
F 6 HOH   24 1024 20  HOH   HOH A . 
F 6 HOH   25 1025 16  HOH   HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC      ? ? ? V1.0        1 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX      ? ? ? 1.20.1_4487 2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? CrysalisPro ? ? ? v2          3 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9LSM 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     73.944 
_cell.length_a_esd                 ? 
_cell.length_b                     73.944 
_cell.length_b_esd                 ? 
_cell.length_c                     131.556 
_cell.length_c_esd                 ? 
_cell.volume                       622949.792 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9LSM 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                152 
_symmetry.space_group_name_Hall            
;P 31 2"
;
_symmetry.space_group_name_H-M             'P 31 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9LSM 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.75 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          55.23 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M MgSO4, 0.1 M Cacodylate sodium salt, pH 6.5, 2.5% ethanol, and 18% PEG3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            298 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'RIGAKU HyPix-3000' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-10-24 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.5418 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        RIGAKU 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.5418 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          40.43 
_reflns.entry_id                                       9LSM 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.7 
_reflns.d_resolution_low                               24.34 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     11922 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.92 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                8.5 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          7.0 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.26 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.7 
_reflns_shell.d_res_low                                     2.8 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1175 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               9.1 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          100 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.93 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               41.55 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9LSM 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.70 
_refine.ls_d_res_low                             24.34 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     11916 
_refine.ls_number_reflns_R_free                  577 
_refine.ls_number_reflns_R_work                  11339 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.87 
_refine.ls_percent_reflns_R_free                 4.84 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2555 
_refine.ls_R_factor_R_free                       0.3041 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2529 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.38 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      2H42 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 35.4716 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3895 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.70 
_refine_hist.d_res_low                        24.34 
_refine_hist.number_atoms_solvent             25 
_refine_hist.number_atoms_total               2362 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2300 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         37 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0019 ? 2381 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.5026 ? 3220 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0346 ? 365  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0033 ? 430  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 5.2744 ? 328  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.70 2.97  . . 117 2815 99.93  . . . . 0.3451 . . . . . . . . . . . 0.3645 
'X-RAY DIFFRACTION' 2.97 3.40  . . 166 2760 100.00 . . . . 0.2905 . . . . . . . . . . . 0.3741 
'X-RAY DIFFRACTION' 3.40 4.28  . . 166 2801 100.00 . . . . 0.2462 . . . . . . . . . . . 0.3027 
'X-RAY DIFFRACTION' 4.28 24.34 . . 128 2963 99.55  . . . . 0.2071 . . . . . . . . . . . 0.2417 
# 
_struct.entry_id                     9LSM 
_struct.title                        'The crystal structure of PDE5A with L9' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9LSM 
_struct_keywords.text            'PDE5A, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
F N N 6 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    PDE5A_HUMAN 
_struct_ref.pdbx_db_accession          O76074 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;EETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHN
WRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILN
SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPI
QQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQ
ALAEQQ
;
_struct_ref.pdbx_align_begin           535 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9LSM 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 326 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             O76074 
_struct_ref_seq.db_align_beg                  535 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  860 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       535 
_struct_ref_seq.pdbx_auth_seq_align_end       860 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 3   ? ALA A 12  ? THR A 537 ALA A 546 1 ? 10 
HELX_P HELX_P2  AA2 SER A 16  ? LYS A 21  ? SER A 550 LYS A 555 1 ? 6  
HELX_P HELX_P3  AA3 SER A 33  ? LEU A 48  ? SER A 567 LEU A 582 1 ? 16 
HELX_P HELX_P4  AA4 ASN A 49  ? PHE A 54  ? ASN A 583 PHE A 588 1 ? 6  
HELX_P HELX_P5  AA5 LYS A 57  ? ASN A 71  ? LYS A 591 ASN A 605 1 ? 15 
HELX_P HELX_P6  AA6 ASN A 80  ? LYS A 96  ? ASN A 614 LYS A 630 1 ? 17 
HELX_P HELX_P7  AA7 LYS A 99  ? LEU A 104 ? LYS A 633 LEU A 638 5 ? 6  
HELX_P HELX_P8  AA8 THR A 105 ? HIS A 119 ? THR A 639 HIS A 653 1 ? 15 
HELX_P HELX_P9  AA9 ILE A 146 ? SER A 161 ? ILE A 680 SER A 695 1 ? 16 
HELX_P HELX_P10 AB1 GLN A 165 ? LEU A 170 ? GLN A 699 LEU A 704 5 ? 6  
HELX_P HELX_P11 AB2 SER A 171 ? THR A 189 ? SER A 705 THR A 723 1 ? 19 
HELX_P HELX_P12 AB3 ASP A 190 ? LYS A 207 ? ASP A 724 LYS A 741 1 ? 18 
HELX_P HELX_P13 AB4 ASP A 214 ? LEU A 231 ? ASP A 748 LEU A 765 1 ? 18 
HELX_P HELX_P14 AB5 SER A 232 ? LYS A 236 ? SER A 766 LYS A 770 5 ? 5  
HELX_P HELX_P15 AB6 PRO A 237 ? PHE A 253 ? PRO A 771 PHE A 787 1 ? 17 
HELX_P HELX_P16 AB7 ILE A 279 ? ILE A 290 ? ILE A 813 ILE A 824 1 ? 12 
HELX_P HELX_P17 AB8 ILE A 290 ? SER A 302 ? ILE A 824 SER A 836 1 ? 13 
HELX_P HELX_P18 AB9 CYS A 305 ? GLU A 324 ? CYS A 839 GLU A 858 1 ? 20 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A HIS 83  NE2 ? ? ? 1_555 C ZN  . ZN ? ? A HIS 617 A ZN  902  1_555 ? ? ? ? ? ? ? 2.305 ? ? 
metalc2  metalc ? ? A HIS 119 NE2 ? ? ? 1_555 C ZN  . ZN ? ? A HIS 653 A ZN  902  1_555 ? ? ? ? ? ? ? 2.300 ? ? 
metalc3  metalc ? ? A ASP 120 OD2 ? ? ? 1_555 C ZN  . ZN ? ? A ASP 654 A ZN  902  1_555 ? ? ? ? ? ? ? 2.268 ? ? 
metalc4  metalc ? ? A ASP 120 OD1 ? ? ? 1_555 D MG  . MG ? ? A ASP 654 A MG  903  1_555 ? ? ? ? ? ? ? 2.531 ? ? 
metalc5  metalc ? ? A ASP 230 OD1 ? ? ? 1_555 C ZN  . ZN ? ? A ASP 764 A ZN  902  1_555 ? ? ? ? ? ? ? 2.042 ? ? 
metalc6  metalc ? ? C ZN  .   ZN  ? ? ? 1_555 F HOH . O  ? ? A ZN  902 A HOH 1002 1_555 ? ? ? ? ? ? ? 2.472 ? ? 
metalc7  metalc ? ? D MG  .   MG  ? ? ? 1_555 F HOH . O  ? ? A MG  903 A HOH 1001 1_555 ? ? ? ? ? ? ? 2.612 ? ? 
metalc8  metalc ? ? D MG  .   MG  ? ? ? 1_555 F HOH . O  ? ? A MG  903 A HOH 1002 1_555 ? ? ? ? ? ? ? 2.357 ? ? 
metalc9  metalc ? ? D MG  .   MG  ? ? ? 1_555 F HOH . O  ? ? A MG  903 A HOH 1006 1_555 ? ? ? ? ? ? ? 2.030 ? ? 
metalc10 metalc ? ? D MG  .   MG  ? ? ? 1_555 F HOH . O  ? ? A MG  903 A HOH 1009 1_555 ? ? ? ? ? ? ? 2.302 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  NE2 ? A HIS 83  ? A HIS 617  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 NE2 ? A HIS 119 ? A HIS 653  ? 1_555 81.9  ? 
2  NE2 ? A HIS 83  ? A HIS 617  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 OD2 ? A ASP 120 ? A ASP 654  ? 1_555 87.8  ? 
3  NE2 ? A HIS 119 ? A HIS 653  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 OD2 ? A ASP 120 ? A ASP 654  ? 1_555 80.8  ? 
4  NE2 ? A HIS 83  ? A HIS 617  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 OD1 ? A ASP 230 ? A ASP 764  ? 1_555 87.2  ? 
5  NE2 ? A HIS 119 ? A HIS 653  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 OD1 ? A ASP 230 ? A ASP 764  ? 1_555 79.8  ? 
6  OD2 ? A ASP 120 ? A ASP 654  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 OD1 ? A ASP 230 ? A ASP 764  ? 1_555 160.4 ? 
7  NE2 ? A HIS 83  ? A HIS 617  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 O   ? F HOH .   ? A HOH 1002 ? 1_555 153.7 ? 
8  NE2 ? A HIS 119 ? A HIS 653  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 O   ? F HOH .   ? A HOH 1002 ? 1_555 117.7 ? 
9  OD2 ? A ASP 120 ? A ASP 654  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 O   ? F HOH .   ? A HOH 1002 ? 1_555 79.0  ? 
10 OD1 ? A ASP 230 ? A ASP 764  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 O   ? F HOH .   ? A HOH 1002 ? 1_555 112.4 ? 
11 OD1 ? A ASP 120 ? A ASP 654  ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? F HOH .   ? A HOH 1001 ? 1_555 86.9  ? 
12 OD1 ? A ASP 120 ? A ASP 654  ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? F HOH .   ? A HOH 1002 ? 1_555 83.5  ? 
13 O   ? F HOH .   ? A HOH 1001 ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? F HOH .   ? A HOH 1002 ? 1_555 67.1  ? 
14 OD1 ? A ASP 120 ? A ASP 654  ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? F HOH .   ? A HOH 1006 ? 1_555 71.5  ? 
15 O   ? F HOH .   ? A HOH 1001 ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? F HOH .   ? A HOH 1006 ? 1_555 132.5 ? 
16 O   ? F HOH .   ? A HOH 1002 ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? F HOH .   ? A HOH 1006 ? 1_555 68.8  ? 
17 OD1 ? A ASP 120 ? A ASP 654  ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? F HOH .   ? A HOH 1009 ? 1_555 143.2 ? 
18 O   ? F HOH .   ? A HOH 1001 ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? F HOH .   ? A HOH 1009 ? 1_555 101.2 ? 
19 O   ? F HOH .   ? A HOH 1002 ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? F HOH .   ? A HOH 1009 ? 1_555 67.6  ? 
20 O   ? F HOH .   ? A HOH 1006 ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? F HOH .   ? A HOH 1009 ? 1_555 77.0  ? 
# 
_pdbx_entry_details.entry_id                   9LSM 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 LYS A 630 ? ? -88.25 -70.39 
2 1 ASN A 661 ? ? -94.47 37.01  
3 1 GLN A 699 ? ? -68.80 79.03  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z          
2 -y,x-y,z+1/3   
3 -x+y,-x,z+2/3  
4 x-y,-y,-z+2/3  
5 -x,-x+y,-z+1/3 
6 y,x,-z         
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLU 535 ? A GLU 1   
2  1 Y 1 A GLU 536 ? A GLU 2   
3  1 Y 1 A SER 663 ? A SER 129 
4  1 Y 1 A TYR 664 ? A TYR 130 
5  1 Y 1 A ILE 665 ? A ILE 131 
6  1 Y 1 A GLN 666 ? A GLN 132 
7  1 Y 1 A ARG 667 ? A ARG 133 
8  1 Y 1 A SER 668 ? A SER 134 
9  1 Y 1 A GLU 669 ? A GLU 135 
10 1 Y 1 A HIS 670 ? A HIS 136 
11 1 Y 1 A PRO 671 ? A PRO 137 
12 1 Y 1 A LEU 672 ? A LEU 138 
13 1 Y 1 A ALA 673 ? A ALA 139 
14 1 Y 1 A GLN 674 ? A GLN 140 
15 1 Y 1 A LEU 675 ? A LEU 141 
16 1 Y 1 A TYR 676 ? A TYR 142 
17 1 Y 1 A CYS 677 ? A CYS 143 
18 1 Y 1 A HIS 678 ? A HIS 144 
19 1 Y 1 A GLY 790 ? A GLY 256 
20 1 Y 1 A ASP 791 ? A ASP 257 
21 1 Y 1 A ARG 792 ? A ARG 258 
22 1 Y 1 A GLU 793 ? A GLU 259 
23 1 Y 1 A ARG 794 ? A ARG 260 
24 1 Y 1 A LYS 795 ? A LYS 261 
25 1 Y 1 A GLU 796 ? A GLU 262 
26 1 Y 1 A LEU 797 ? A LEU 263 
27 1 Y 1 A ASN 798 ? A ASN 264 
28 1 Y 1 A ILE 799 ? A ILE 265 
29 1 Y 1 A GLU 800 ? A GLU 266 
30 1 Y 1 A PRO 801 ? A PRO 267 
31 1 Y 1 A THR 802 ? A THR 268 
32 1 Y 1 A ASP 803 ? A ASP 269 
33 1 Y 1 A LEU 804 ? A LEU 270 
34 1 Y 1 A MET 805 ? A MET 271 
35 1 Y 1 A ASN 806 ? A ASN 272 
36 1 Y 1 A ARG 807 ? A ARG 273 
37 1 Y 1 A GLU 808 ? A GLU 274 
38 1 Y 1 A LYS 809 ? A LYS 275 
39 1 Y 1 A LYS 810 ? A LYS 276 
40 1 Y 1 A ASN 811 ? A ASN 277 
41 1 Y 1 A GLN 860 ? A GLN 326 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1ELC C10  C  Y N 1   
A1ELC C11  C  Y N 2   
A1ELC C12  C  N N 3   
A1ELC C13  C  Y N 4   
A1ELC C14  C  Y N 5   
A1ELC C15  C  N N 6   
A1ELC C16  C  N S 7   
A1ELC C17  C  N N 8   
A1ELC C18  C  N N 9   
A1ELC C19  C  N N 10  
A1ELC C20  C  N N 11  
A1ELC N    N  Y N 12  
A1ELC C    C  Y N 13  
A1ELC O    O  N N 14  
A1ELC C1   C  Y N 15  
A1ELC C2   C  Y N 16  
A1ELC C21  C  Y N 17  
A1ELC C22  C  Y N 18  
A1ELC C3   C  Y N 19  
A1ELC C4   C  Y N 20  
A1ELC C5   C  Y N 21  
A1ELC C6   C  Y N 22  
A1ELC C7   C  N R 23  
A1ELC C8   C  Y N 24  
A1ELC C9   C  Y N 25  
A1ELC N1   N  N N 26  
A1ELC N2   N  N N 27  
A1ELC O1   O  N N 28  
A1ELC BR   BR N N 29  
A1ELC CL   CL N N 30  
A1ELC H1   H  N N 31  
A1ELC H2   H  N N 32  
A1ELC H3   H  N N 33  
A1ELC H4   H  N N 34  
A1ELC H5   H  N N 35  
A1ELC H6   H  N N 36  
A1ELC H7   H  N N 37  
A1ELC H8   H  N N 38  
A1ELC H9   H  N N 39  
A1ELC H10  H  N N 40  
A1ELC H11  H  N N 41  
A1ELC H12  H  N N 42  
A1ELC H13  H  N N 43  
A1ELC H14  H  N N 44  
A1ELC H15  H  N N 45  
A1ELC H16  H  N N 46  
A1ELC H17  H  N N 47  
A1ELC H18  H  N N 48  
A1ELC H19  H  N N 49  
A1ELC H20  H  N N 50  
A1ELC H21  H  N N 51  
ALA   N    N  N N 52  
ALA   CA   C  N S 53  
ALA   C    C  N N 54  
ALA   O    O  N N 55  
ALA   CB   C  N N 56  
ALA   OXT  O  N N 57  
ALA   H    H  N N 58  
ALA   H2   H  N N 59  
ALA   HA   H  N N 60  
ALA   HB1  H  N N 61  
ALA   HB2  H  N N 62  
ALA   HB3  H  N N 63  
ALA   HXT  H  N N 64  
ARG   N    N  N N 65  
ARG   CA   C  N S 66  
ARG   C    C  N N 67  
ARG   O    O  N N 68  
ARG   CB   C  N N 69  
ARG   CG   C  N N 70  
ARG   CD   C  N N 71  
ARG   NE   N  N N 72  
ARG   CZ   C  N N 73  
ARG   NH1  N  N N 74  
ARG   NH2  N  N N 75  
ARG   OXT  O  N N 76  
ARG   H    H  N N 77  
ARG   H2   H  N N 78  
ARG   HA   H  N N 79  
ARG   HB2  H  N N 80  
ARG   HB3  H  N N 81  
ARG   HG2  H  N N 82  
ARG   HG3  H  N N 83  
ARG   HD2  H  N N 84  
ARG   HD3  H  N N 85  
ARG   HE   H  N N 86  
ARG   HH11 H  N N 87  
ARG   HH12 H  N N 88  
ARG   HH21 H  N N 89  
ARG   HH22 H  N N 90  
ARG   HXT  H  N N 91  
ASN   N    N  N N 92  
ASN   CA   C  N S 93  
ASN   C    C  N N 94  
ASN   O    O  N N 95  
ASN   CB   C  N N 96  
ASN   CG   C  N N 97  
ASN   OD1  O  N N 98  
ASN   ND2  N  N N 99  
ASN   OXT  O  N N 100 
ASN   H    H  N N 101 
ASN   H2   H  N N 102 
ASN   HA   H  N N 103 
ASN   HB2  H  N N 104 
ASN   HB3  H  N N 105 
ASN   HD21 H  N N 106 
ASN   HD22 H  N N 107 
ASN   HXT  H  N N 108 
ASP   N    N  N N 109 
ASP   CA   C  N S 110 
ASP   C    C  N N 111 
ASP   O    O  N N 112 
ASP   CB   C  N N 113 
ASP   CG   C  N N 114 
ASP   OD1  O  N N 115 
ASP   OD2  O  N N 116 
ASP   OXT  O  N N 117 
ASP   H    H  N N 118 
ASP   H2   H  N N 119 
ASP   HA   H  N N 120 
ASP   HB2  H  N N 121 
ASP   HB3  H  N N 122 
ASP   HD2  H  N N 123 
ASP   HXT  H  N N 124 
CYS   N    N  N N 125 
CYS   CA   C  N R 126 
CYS   C    C  N N 127 
CYS   O    O  N N 128 
CYS   CB   C  N N 129 
CYS   SG   S  N N 130 
CYS   OXT  O  N N 131 
CYS   H    H  N N 132 
CYS   H2   H  N N 133 
CYS   HA   H  N N 134 
CYS   HB2  H  N N 135 
CYS   HB3  H  N N 136 
CYS   HG   H  N N 137 
CYS   HXT  H  N N 138 
GLN   N    N  N N 139 
GLN   CA   C  N S 140 
GLN   C    C  N N 141 
GLN   O    O  N N 142 
GLN   CB   C  N N 143 
GLN   CG   C  N N 144 
GLN   CD   C  N N 145 
GLN   OE1  O  N N 146 
GLN   NE2  N  N N 147 
GLN   OXT  O  N N 148 
GLN   H    H  N N 149 
GLN   H2   H  N N 150 
GLN   HA   H  N N 151 
GLN   HB2  H  N N 152 
GLN   HB3  H  N N 153 
GLN   HG2  H  N N 154 
GLN   HG3  H  N N 155 
GLN   HE21 H  N N 156 
GLN   HE22 H  N N 157 
GLN   HXT  H  N N 158 
GLU   N    N  N N 159 
GLU   CA   C  N S 160 
GLU   C    C  N N 161 
GLU   O    O  N N 162 
GLU   CB   C  N N 163 
GLU   CG   C  N N 164 
GLU   CD   C  N N 165 
GLU   OE1  O  N N 166 
GLU   OE2  O  N N 167 
GLU   OXT  O  N N 168 
GLU   H    H  N N 169 
GLU   H2   H  N N 170 
GLU   HA   H  N N 171 
GLU   HB2  H  N N 172 
GLU   HB3  H  N N 173 
GLU   HG2  H  N N 174 
GLU   HG3  H  N N 175 
GLU   HE2  H  N N 176 
GLU   HXT  H  N N 177 
GLY   N    N  N N 178 
GLY   CA   C  N N 179 
GLY   C    C  N N 180 
GLY   O    O  N N 181 
GLY   OXT  O  N N 182 
GLY   H    H  N N 183 
GLY   H2   H  N N 184 
GLY   HA2  H  N N 185 
GLY   HA3  H  N N 186 
GLY   HXT  H  N N 187 
HIS   N    N  N N 188 
HIS   CA   C  N S 189 
HIS   C    C  N N 190 
HIS   O    O  N N 191 
HIS   CB   C  N N 192 
HIS   CG   C  Y N 193 
HIS   ND1  N  Y N 194 
HIS   CD2  C  Y N 195 
HIS   CE1  C  Y N 196 
HIS   NE2  N  Y N 197 
HIS   OXT  O  N N 198 
HIS   H    H  N N 199 
HIS   H2   H  N N 200 
HIS   HA   H  N N 201 
HIS   HB2  H  N N 202 
HIS   HB3  H  N N 203 
HIS   HD1  H  N N 204 
HIS   HD2  H  N N 205 
HIS   HE1  H  N N 206 
HIS   HE2  H  N N 207 
HIS   HXT  H  N N 208 
HOH   O    O  N N 209 
HOH   H1   H  N N 210 
HOH   H2   H  N N 211 
ILE   N    N  N N 212 
ILE   CA   C  N S 213 
ILE   C    C  N N 214 
ILE   O    O  N N 215 
ILE   CB   C  N S 216 
ILE   CG1  C  N N 217 
ILE   CG2  C  N N 218 
ILE   CD1  C  N N 219 
ILE   OXT  O  N N 220 
ILE   H    H  N N 221 
ILE   H2   H  N N 222 
ILE   HA   H  N N 223 
ILE   HB   H  N N 224 
ILE   HG12 H  N N 225 
ILE   HG13 H  N N 226 
ILE   HG21 H  N N 227 
ILE   HG22 H  N N 228 
ILE   HG23 H  N N 229 
ILE   HD11 H  N N 230 
ILE   HD12 H  N N 231 
ILE   HD13 H  N N 232 
ILE   HXT  H  N N 233 
LEU   N    N  N N 234 
LEU   CA   C  N S 235 
LEU   C    C  N N 236 
LEU   O    O  N N 237 
LEU   CB   C  N N 238 
LEU   CG   C  N N 239 
LEU   CD1  C  N N 240 
LEU   CD2  C  N N 241 
LEU   OXT  O  N N 242 
LEU   H    H  N N 243 
LEU   H2   H  N N 244 
LEU   HA   H  N N 245 
LEU   HB2  H  N N 246 
LEU   HB3  H  N N 247 
LEU   HG   H  N N 248 
LEU   HD11 H  N N 249 
LEU   HD12 H  N N 250 
LEU   HD13 H  N N 251 
LEU   HD21 H  N N 252 
LEU   HD22 H  N N 253 
LEU   HD23 H  N N 254 
LEU   HXT  H  N N 255 
LYS   N    N  N N 256 
LYS   CA   C  N S 257 
LYS   C    C  N N 258 
LYS   O    O  N N 259 
LYS   CB   C  N N 260 
LYS   CG   C  N N 261 
LYS   CD   C  N N 262 
LYS   CE   C  N N 263 
LYS   NZ   N  N N 264 
LYS   OXT  O  N N 265 
LYS   H    H  N N 266 
LYS   H2   H  N N 267 
LYS   HA   H  N N 268 
LYS   HB2  H  N N 269 
LYS   HB3  H  N N 270 
LYS   HG2  H  N N 271 
LYS   HG3  H  N N 272 
LYS   HD2  H  N N 273 
LYS   HD3  H  N N 274 
LYS   HE2  H  N N 275 
LYS   HE3  H  N N 276 
LYS   HZ1  H  N N 277 
LYS   HZ2  H  N N 278 
LYS   HZ3  H  N N 279 
LYS   HXT  H  N N 280 
MET   N    N  N N 281 
MET   CA   C  N S 282 
MET   C    C  N N 283 
MET   O    O  N N 284 
MET   CB   C  N N 285 
MET   CG   C  N N 286 
MET   SD   S  N N 287 
MET   CE   C  N N 288 
MET   OXT  O  N N 289 
MET   H    H  N N 290 
MET   H2   H  N N 291 
MET   HA   H  N N 292 
MET   HB2  H  N N 293 
MET   HB3  H  N N 294 
MET   HG2  H  N N 295 
MET   HG3  H  N N 296 
MET   HE1  H  N N 297 
MET   HE2  H  N N 298 
MET   HE3  H  N N 299 
MET   HXT  H  N N 300 
MG    MG   MG N N 301 
PHE   N    N  N N 302 
PHE   CA   C  N S 303 
PHE   C    C  N N 304 
PHE   O    O  N N 305 
PHE   CB   C  N N 306 
PHE   CG   C  Y N 307 
PHE   CD1  C  Y N 308 
PHE   CD2  C  Y N 309 
PHE   CE1  C  Y N 310 
PHE   CE2  C  Y N 311 
PHE   CZ   C  Y N 312 
PHE   OXT  O  N N 313 
PHE   H    H  N N 314 
PHE   H2   H  N N 315 
PHE   HA   H  N N 316 
PHE   HB2  H  N N 317 
PHE   HB3  H  N N 318 
PHE   HD1  H  N N 319 
PHE   HD2  H  N N 320 
PHE   HE1  H  N N 321 
PHE   HE2  H  N N 322 
PHE   HZ   H  N N 323 
PHE   HXT  H  N N 324 
PRO   N    N  N N 325 
PRO   CA   C  N S 326 
PRO   C    C  N N 327 
PRO   O    O  N N 328 
PRO   CB   C  N N 329 
PRO   CG   C  N N 330 
PRO   CD   C  N N 331 
PRO   OXT  O  N N 332 
PRO   H    H  N N 333 
PRO   HA   H  N N 334 
PRO   HB2  H  N N 335 
PRO   HB3  H  N N 336 
PRO   HG2  H  N N 337 
PRO   HG3  H  N N 338 
PRO   HD2  H  N N 339 
PRO   HD3  H  N N 340 
PRO   HXT  H  N N 341 
SER   N    N  N N 342 
SER   CA   C  N S 343 
SER   C    C  N N 344 
SER   O    O  N N 345 
SER   CB   C  N N 346 
SER   OG   O  N N 347 
SER   OXT  O  N N 348 
SER   H    H  N N 349 
SER   H2   H  N N 350 
SER   HA   H  N N 351 
SER   HB2  H  N N 352 
SER   HB3  H  N N 353 
SER   HG   H  N N 354 
SER   HXT  H  N N 355 
SO4   S    S  N N 356 
SO4   O1   O  N N 357 
SO4   O2   O  N N 358 
SO4   O3   O  N N 359 
SO4   O4   O  N N 360 
THR   N    N  N N 361 
THR   CA   C  N S 362 
THR   C    C  N N 363 
THR   O    O  N N 364 
THR   CB   C  N R 365 
THR   OG1  O  N N 366 
THR   CG2  C  N N 367 
THR   OXT  O  N N 368 
THR   H    H  N N 369 
THR   H2   H  N N 370 
THR   HA   H  N N 371 
THR   HB   H  N N 372 
THR   HG1  H  N N 373 
THR   HG21 H  N N 374 
THR   HG22 H  N N 375 
THR   HG23 H  N N 376 
THR   HXT  H  N N 377 
TRP   N    N  N N 378 
TRP   CA   C  N S 379 
TRP   C    C  N N 380 
TRP   O    O  N N 381 
TRP   CB   C  N N 382 
TRP   CG   C  Y N 383 
TRP   CD1  C  Y N 384 
TRP   CD2  C  Y N 385 
TRP   NE1  N  Y N 386 
TRP   CE2  C  Y N 387 
TRP   CE3  C  Y N 388 
TRP   CZ2  C  Y N 389 
TRP   CZ3  C  Y N 390 
TRP   CH2  C  Y N 391 
TRP   OXT  O  N N 392 
TRP   H    H  N N 393 
TRP   H2   H  N N 394 
TRP   HA   H  N N 395 
TRP   HB2  H  N N 396 
TRP   HB3  H  N N 397 
TRP   HD1  H  N N 398 
TRP   HE1  H  N N 399 
TRP   HE3  H  N N 400 
TRP   HZ2  H  N N 401 
TRP   HZ3  H  N N 402 
TRP   HH2  H  N N 403 
TRP   HXT  H  N N 404 
TYR   N    N  N N 405 
TYR   CA   C  N S 406 
TYR   C    C  N N 407 
TYR   O    O  N N 408 
TYR   CB   C  N N 409 
TYR   CG   C  Y N 410 
TYR   CD1  C  Y N 411 
TYR   CD2  C  Y N 412 
TYR   CE1  C  Y N 413 
TYR   CE2  C  Y N 414 
TYR   CZ   C  Y N 415 
TYR   OH   O  N N 416 
TYR   OXT  O  N N 417 
TYR   H    H  N N 418 
TYR   H2   H  N N 419 
TYR   HA   H  N N 420 
TYR   HB2  H  N N 421 
TYR   HB3  H  N N 422 
TYR   HD1  H  N N 423 
TYR   HD2  H  N N 424 
TYR   HE1  H  N N 425 
TYR   HE2  H  N N 426 
TYR   HH   H  N N 427 
TYR   HXT  H  N N 428 
VAL   N    N  N N 429 
VAL   CA   C  N S 430 
VAL   C    C  N N 431 
VAL   O    O  N N 432 
VAL   CB   C  N N 433 
VAL   CG1  C  N N 434 
VAL   CG2  C  N N 435 
VAL   OXT  O  N N 436 
VAL   H    H  N N 437 
VAL   H2   H  N N 438 
VAL   HA   H  N N 439 
VAL   HB   H  N N 440 
VAL   HG11 H  N N 441 
VAL   HG12 H  N N 442 
VAL   HG13 H  N N 443 
VAL   HG21 H  N N 444 
VAL   HG22 H  N N 445 
VAL   HG23 H  N N 446 
VAL   HXT  H  N N 447 
ZN    ZN   ZN N N 448 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1ELC C12 O    sing N N 1   
A1ELC C10 C9   doub Y N 2   
A1ELC C10 C11  sing Y N 3   
A1ELC C9  C8   sing Y N 4   
A1ELC O1  C17  doub N N 5   
A1ELC O   C11  sing N N 6   
A1ELC C11 C13  doub Y N 7   
A1ELC C8  C7   sing N N 8   
A1ELC C8  C14  doub Y N 9   
A1ELC C15 C7   sing N N 10  
A1ELC C15 C16  sing N N 11  
A1ELC C18 C17  sing N N 12  
A1ELC C17 N2   sing N N 13  
A1ELC C7  N1   sing N N 14  
A1ELC C13 C14  sing Y N 15  
A1ELC C13 CL   sing N N 16  
A1ELC N2  C16  sing N N 17  
A1ELC N2  C19  sing N N 18  
A1ELC C16 C5   sing N N 19  
A1ELC N1  C6   sing N N 20  
A1ELC C19 C20  sing N N 21  
A1ELC C5  C6   doub Y N 22  
A1ELC C5  C4   sing Y N 23  
A1ELC C6  C21  sing Y N 24  
A1ELC C20 C4   sing N N 25  
A1ELC C4  N    doub Y N 26  
A1ELC C21 C22  doub Y N 27  
A1ELC C21 C3   sing Y N 28  
A1ELC C22 C    sing Y N 29  
A1ELC N   C3   sing Y N 30  
A1ELC C3  C2   doub Y N 31  
A1ELC C   BR   sing N N 32  
A1ELC C   C1   doub Y N 33  
A1ELC C2  C1   sing Y N 34  
A1ELC C10 H1   sing N N 35  
A1ELC C12 H2   sing N N 36  
A1ELC C12 H3   sing N N 37  
A1ELC C12 H4   sing N N 38  
A1ELC C14 H5   sing N N 39  
A1ELC C15 H6   sing N N 40  
A1ELC C15 H7   sing N N 41  
A1ELC C16 H8   sing N N 42  
A1ELC C18 H9   sing N N 43  
A1ELC C18 H10  sing N N 44  
A1ELC C18 H11  sing N N 45  
A1ELC C19 H12  sing N N 46  
A1ELC C19 H13  sing N N 47  
A1ELC C20 H14  sing N N 48  
A1ELC C20 H15  sing N N 49  
A1ELC C1  H16  sing N N 50  
A1ELC C2  H17  sing N N 51  
A1ELC C22 H18  sing N N 52  
A1ELC C7  H19  sing N N 53  
A1ELC C9  H20  sing N N 54  
A1ELC N1  H21  sing N N 55  
ALA   N   CA   sing N N 56  
ALA   N   H    sing N N 57  
ALA   N   H2   sing N N 58  
ALA   CA  C    sing N N 59  
ALA   CA  CB   sing N N 60  
ALA   CA  HA   sing N N 61  
ALA   C   O    doub N N 62  
ALA   C   OXT  sing N N 63  
ALA   CB  HB1  sing N N 64  
ALA   CB  HB2  sing N N 65  
ALA   CB  HB3  sing N N 66  
ALA   OXT HXT  sing N N 67  
ARG   N   CA   sing N N 68  
ARG   N   H    sing N N 69  
ARG   N   H2   sing N N 70  
ARG   CA  C    sing N N 71  
ARG   CA  CB   sing N N 72  
ARG   CA  HA   sing N N 73  
ARG   C   O    doub N N 74  
ARG   C   OXT  sing N N 75  
ARG   CB  CG   sing N N 76  
ARG   CB  HB2  sing N N 77  
ARG   CB  HB3  sing N N 78  
ARG   CG  CD   sing N N 79  
ARG   CG  HG2  sing N N 80  
ARG   CG  HG3  sing N N 81  
ARG   CD  NE   sing N N 82  
ARG   CD  HD2  sing N N 83  
ARG   CD  HD3  sing N N 84  
ARG   NE  CZ   sing N N 85  
ARG   NE  HE   sing N N 86  
ARG   CZ  NH1  sing N N 87  
ARG   CZ  NH2  doub N N 88  
ARG   NH1 HH11 sing N N 89  
ARG   NH1 HH12 sing N N 90  
ARG   NH2 HH21 sing N N 91  
ARG   NH2 HH22 sing N N 92  
ARG   OXT HXT  sing N N 93  
ASN   N   CA   sing N N 94  
ASN   N   H    sing N N 95  
ASN   N   H2   sing N N 96  
ASN   CA  C    sing N N 97  
ASN   CA  CB   sing N N 98  
ASN   CA  HA   sing N N 99  
ASN   C   O    doub N N 100 
ASN   C   OXT  sing N N 101 
ASN   CB  CG   sing N N 102 
ASN   CB  HB2  sing N N 103 
ASN   CB  HB3  sing N N 104 
ASN   CG  OD1  doub N N 105 
ASN   CG  ND2  sing N N 106 
ASN   ND2 HD21 sing N N 107 
ASN   ND2 HD22 sing N N 108 
ASN   OXT HXT  sing N N 109 
ASP   N   CA   sing N N 110 
ASP   N   H    sing N N 111 
ASP   N   H2   sing N N 112 
ASP   CA  C    sing N N 113 
ASP   CA  CB   sing N N 114 
ASP   CA  HA   sing N N 115 
ASP   C   O    doub N N 116 
ASP   C   OXT  sing N N 117 
ASP   CB  CG   sing N N 118 
ASP   CB  HB2  sing N N 119 
ASP   CB  HB3  sing N N 120 
ASP   CG  OD1  doub N N 121 
ASP   CG  OD2  sing N N 122 
ASP   OD2 HD2  sing N N 123 
ASP   OXT HXT  sing N N 124 
CYS   N   CA   sing N N 125 
CYS   N   H    sing N N 126 
CYS   N   H2   sing N N 127 
CYS   CA  C    sing N N 128 
CYS   CA  CB   sing N N 129 
CYS   CA  HA   sing N N 130 
CYS   C   O    doub N N 131 
CYS   C   OXT  sing N N 132 
CYS   CB  SG   sing N N 133 
CYS   CB  HB2  sing N N 134 
CYS   CB  HB3  sing N N 135 
CYS   SG  HG   sing N N 136 
CYS   OXT HXT  sing N N 137 
GLN   N   CA   sing N N 138 
GLN   N   H    sing N N 139 
GLN   N   H2   sing N N 140 
GLN   CA  C    sing N N 141 
GLN   CA  CB   sing N N 142 
GLN   CA  HA   sing N N 143 
GLN   C   O    doub N N 144 
GLN   C   OXT  sing N N 145 
GLN   CB  CG   sing N N 146 
GLN   CB  HB2  sing N N 147 
GLN   CB  HB3  sing N N 148 
GLN   CG  CD   sing N N 149 
GLN   CG  HG2  sing N N 150 
GLN   CG  HG3  sing N N 151 
GLN   CD  OE1  doub N N 152 
GLN   CD  NE2  sing N N 153 
GLN   NE2 HE21 sing N N 154 
GLN   NE2 HE22 sing N N 155 
GLN   OXT HXT  sing N N 156 
GLU   N   CA   sing N N 157 
GLU   N   H    sing N N 158 
GLU   N   H2   sing N N 159 
GLU   CA  C    sing N N 160 
GLU   CA  CB   sing N N 161 
GLU   CA  HA   sing N N 162 
GLU   C   O    doub N N 163 
GLU   C   OXT  sing N N 164 
GLU   CB  CG   sing N N 165 
GLU   CB  HB2  sing N N 166 
GLU   CB  HB3  sing N N 167 
GLU   CG  CD   sing N N 168 
GLU   CG  HG2  sing N N 169 
GLU   CG  HG3  sing N N 170 
GLU   CD  OE1  doub N N 171 
GLU   CD  OE2  sing N N 172 
GLU   OE2 HE2  sing N N 173 
GLU   OXT HXT  sing N N 174 
GLY   N   CA   sing N N 175 
GLY   N   H    sing N N 176 
GLY   N   H2   sing N N 177 
GLY   CA  C    sing N N 178 
GLY   CA  HA2  sing N N 179 
GLY   CA  HA3  sing N N 180 
GLY   C   O    doub N N 181 
GLY   C   OXT  sing N N 182 
GLY   OXT HXT  sing N N 183 
HIS   N   CA   sing N N 184 
HIS   N   H    sing N N 185 
HIS   N   H2   sing N N 186 
HIS   CA  C    sing N N 187 
HIS   CA  CB   sing N N 188 
HIS   CA  HA   sing N N 189 
HIS   C   O    doub N N 190 
HIS   C   OXT  sing N N 191 
HIS   CB  CG   sing N N 192 
HIS   CB  HB2  sing N N 193 
HIS   CB  HB3  sing N N 194 
HIS   CG  ND1  sing Y N 195 
HIS   CG  CD2  doub Y N 196 
HIS   ND1 CE1  doub Y N 197 
HIS   ND1 HD1  sing N N 198 
HIS   CD2 NE2  sing Y N 199 
HIS   CD2 HD2  sing N N 200 
HIS   CE1 NE2  sing Y N 201 
HIS   CE1 HE1  sing N N 202 
HIS   NE2 HE2  sing N N 203 
HIS   OXT HXT  sing N N 204 
HOH   O   H1   sing N N 205 
HOH   O   H2   sing N N 206 
ILE   N   CA   sing N N 207 
ILE   N   H    sing N N 208 
ILE   N   H2   sing N N 209 
ILE   CA  C    sing N N 210 
ILE   CA  CB   sing N N 211 
ILE   CA  HA   sing N N 212 
ILE   C   O    doub N N 213 
ILE   C   OXT  sing N N 214 
ILE   CB  CG1  sing N N 215 
ILE   CB  CG2  sing N N 216 
ILE   CB  HB   sing N N 217 
ILE   CG1 CD1  sing N N 218 
ILE   CG1 HG12 sing N N 219 
ILE   CG1 HG13 sing N N 220 
ILE   CG2 HG21 sing N N 221 
ILE   CG2 HG22 sing N N 222 
ILE   CG2 HG23 sing N N 223 
ILE   CD1 HD11 sing N N 224 
ILE   CD1 HD12 sing N N 225 
ILE   CD1 HD13 sing N N 226 
ILE   OXT HXT  sing N N 227 
LEU   N   CA   sing N N 228 
LEU   N   H    sing N N 229 
LEU   N   H2   sing N N 230 
LEU   CA  C    sing N N 231 
LEU   CA  CB   sing N N 232 
LEU   CA  HA   sing N N 233 
LEU   C   O    doub N N 234 
LEU   C   OXT  sing N N 235 
LEU   CB  CG   sing N N 236 
LEU   CB  HB2  sing N N 237 
LEU   CB  HB3  sing N N 238 
LEU   CG  CD1  sing N N 239 
LEU   CG  CD2  sing N N 240 
LEU   CG  HG   sing N N 241 
LEU   CD1 HD11 sing N N 242 
LEU   CD1 HD12 sing N N 243 
LEU   CD1 HD13 sing N N 244 
LEU   CD2 HD21 sing N N 245 
LEU   CD2 HD22 sing N N 246 
LEU   CD2 HD23 sing N N 247 
LEU   OXT HXT  sing N N 248 
LYS   N   CA   sing N N 249 
LYS   N   H    sing N N 250 
LYS   N   H2   sing N N 251 
LYS   CA  C    sing N N 252 
LYS   CA  CB   sing N N 253 
LYS   CA  HA   sing N N 254 
LYS   C   O    doub N N 255 
LYS   C   OXT  sing N N 256 
LYS   CB  CG   sing N N 257 
LYS   CB  HB2  sing N N 258 
LYS   CB  HB3  sing N N 259 
LYS   CG  CD   sing N N 260 
LYS   CG  HG2  sing N N 261 
LYS   CG  HG3  sing N N 262 
LYS   CD  CE   sing N N 263 
LYS   CD  HD2  sing N N 264 
LYS   CD  HD3  sing N N 265 
LYS   CE  NZ   sing N N 266 
LYS   CE  HE2  sing N N 267 
LYS   CE  HE3  sing N N 268 
LYS   NZ  HZ1  sing N N 269 
LYS   NZ  HZ2  sing N N 270 
LYS   NZ  HZ3  sing N N 271 
LYS   OXT HXT  sing N N 272 
MET   N   CA   sing N N 273 
MET   N   H    sing N N 274 
MET   N   H2   sing N N 275 
MET   CA  C    sing N N 276 
MET   CA  CB   sing N N 277 
MET   CA  HA   sing N N 278 
MET   C   O    doub N N 279 
MET   C   OXT  sing N N 280 
MET   CB  CG   sing N N 281 
MET   CB  HB2  sing N N 282 
MET   CB  HB3  sing N N 283 
MET   CG  SD   sing N N 284 
MET   CG  HG2  sing N N 285 
MET   CG  HG3  sing N N 286 
MET   SD  CE   sing N N 287 
MET   CE  HE1  sing N N 288 
MET   CE  HE2  sing N N 289 
MET   CE  HE3  sing N N 290 
MET   OXT HXT  sing N N 291 
PHE   N   CA   sing N N 292 
PHE   N   H    sing N N 293 
PHE   N   H2   sing N N 294 
PHE   CA  C    sing N N 295 
PHE   CA  CB   sing N N 296 
PHE   CA  HA   sing N N 297 
PHE   C   O    doub N N 298 
PHE   C   OXT  sing N N 299 
PHE   CB  CG   sing N N 300 
PHE   CB  HB2  sing N N 301 
PHE   CB  HB3  sing N N 302 
PHE   CG  CD1  doub Y N 303 
PHE   CG  CD2  sing Y N 304 
PHE   CD1 CE1  sing Y N 305 
PHE   CD1 HD1  sing N N 306 
PHE   CD2 CE2  doub Y N 307 
PHE   CD2 HD2  sing N N 308 
PHE   CE1 CZ   doub Y N 309 
PHE   CE1 HE1  sing N N 310 
PHE   CE2 CZ   sing Y N 311 
PHE   CE2 HE2  sing N N 312 
PHE   CZ  HZ   sing N N 313 
PHE   OXT HXT  sing N N 314 
PRO   N   CA   sing N N 315 
PRO   N   CD   sing N N 316 
PRO   N   H    sing N N 317 
PRO   CA  C    sing N N 318 
PRO   CA  CB   sing N N 319 
PRO   CA  HA   sing N N 320 
PRO   C   O    doub N N 321 
PRO   C   OXT  sing N N 322 
PRO   CB  CG   sing N N 323 
PRO   CB  HB2  sing N N 324 
PRO   CB  HB3  sing N N 325 
PRO   CG  CD   sing N N 326 
PRO   CG  HG2  sing N N 327 
PRO   CG  HG3  sing N N 328 
PRO   CD  HD2  sing N N 329 
PRO   CD  HD3  sing N N 330 
PRO   OXT HXT  sing N N 331 
SER   N   CA   sing N N 332 
SER   N   H    sing N N 333 
SER   N   H2   sing N N 334 
SER   CA  C    sing N N 335 
SER   CA  CB   sing N N 336 
SER   CA  HA   sing N N 337 
SER   C   O    doub N N 338 
SER   C   OXT  sing N N 339 
SER   CB  OG   sing N N 340 
SER   CB  HB2  sing N N 341 
SER   CB  HB3  sing N N 342 
SER   OG  HG   sing N N 343 
SER   OXT HXT  sing N N 344 
SO4   S   O1   doub N N 345 
SO4   S   O2   doub N N 346 
SO4   S   O3   sing N N 347 
SO4   S   O4   sing N N 348 
THR   N   CA   sing N N 349 
THR   N   H    sing N N 350 
THR   N   H2   sing N N 351 
THR   CA  C    sing N N 352 
THR   CA  CB   sing N N 353 
THR   CA  HA   sing N N 354 
THR   C   O    doub N N 355 
THR   C   OXT  sing N N 356 
THR   CB  OG1  sing N N 357 
THR   CB  CG2  sing N N 358 
THR   CB  HB   sing N N 359 
THR   OG1 HG1  sing N N 360 
THR   CG2 HG21 sing N N 361 
THR   CG2 HG22 sing N N 362 
THR   CG2 HG23 sing N N 363 
THR   OXT HXT  sing N N 364 
TRP   N   CA   sing N N 365 
TRP   N   H    sing N N 366 
TRP   N   H2   sing N N 367 
TRP   CA  C    sing N N 368 
TRP   CA  CB   sing N N 369 
TRP   CA  HA   sing N N 370 
TRP   C   O    doub N N 371 
TRP   C   OXT  sing N N 372 
TRP   CB  CG   sing N N 373 
TRP   CB  HB2  sing N N 374 
TRP   CB  HB3  sing N N 375 
TRP   CG  CD1  doub Y N 376 
TRP   CG  CD2  sing Y N 377 
TRP   CD1 NE1  sing Y N 378 
TRP   CD1 HD1  sing N N 379 
TRP   CD2 CE2  doub Y N 380 
TRP   CD2 CE3  sing Y N 381 
TRP   NE1 CE2  sing Y N 382 
TRP   NE1 HE1  sing N N 383 
TRP   CE2 CZ2  sing Y N 384 
TRP   CE3 CZ3  doub Y N 385 
TRP   CE3 HE3  sing N N 386 
TRP   CZ2 CH2  doub Y N 387 
TRP   CZ2 HZ2  sing N N 388 
TRP   CZ3 CH2  sing Y N 389 
TRP   CZ3 HZ3  sing N N 390 
TRP   CH2 HH2  sing N N 391 
TRP   OXT HXT  sing N N 392 
TYR   N   CA   sing N N 393 
TYR   N   H    sing N N 394 
TYR   N   H2   sing N N 395 
TYR   CA  C    sing N N 396 
TYR   CA  CB   sing N N 397 
TYR   CA  HA   sing N N 398 
TYR   C   O    doub N N 399 
TYR   C   OXT  sing N N 400 
TYR   CB  CG   sing N N 401 
TYR   CB  HB2  sing N N 402 
TYR   CB  HB3  sing N N 403 
TYR   CG  CD1  doub Y N 404 
TYR   CG  CD2  sing Y N 405 
TYR   CD1 CE1  sing Y N 406 
TYR   CD1 HD1  sing N N 407 
TYR   CD2 CE2  doub Y N 408 
TYR   CD2 HD2  sing N N 409 
TYR   CE1 CZ   doub Y N 410 
TYR   CE1 HE1  sing N N 411 
TYR   CE2 CZ   sing Y N 412 
TYR   CE2 HE2  sing N N 413 
TYR   CZ  OH   sing N N 414 
TYR   OH  HH   sing N N 415 
TYR   OXT HXT  sing N N 416 
VAL   N   CA   sing N N 417 
VAL   N   H    sing N N 418 
VAL   N   H2   sing N N 419 
VAL   CA  C    sing N N 420 
VAL   CA  CB   sing N N 421 
VAL   CA  HA   sing N N 422 
VAL   C   O    doub N N 423 
VAL   C   OXT  sing N N 424 
VAL   CB  CG1  sing N N 425 
VAL   CB  CG2  sing N N 426 
VAL   CB  HB   sing N N 427 
VAL   CG1 HG11 sing N N 428 
VAL   CG1 HG12 sing N N 429 
VAL   CG1 HG13 sing N N 430 
VAL   CG2 HG21 sing N N 431 
VAL   CG2 HG22 sing N N 432 
VAL   CG2 HG23 sing N N 433 
VAL   OXT HXT  sing N N 434 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           82373732 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   2H42 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 31 2 1' 
_space_group.name_Hall        
;P 31 2"
;
_space_group.IT_number        152 
_space_group.crystal_system   trigonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9LSM 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.013524 
_atom_sites.fract_transf_matrix[1][2]   0.007808 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.015616 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.007601 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
BR  ? ? 25.79822 9.11301 ? ? 1.35700  25.34896 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
C   ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CL  ? ? 9.50761  7.44341 ? ? 1.04373  23.83732 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
MG  ? ? 9.41153  2.53737 ? ? 2.59044  63.03566 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N   ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O   ? ? 7.96527  ?       ? ? 9.05267  ?        ? ? 0.0 
;1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O1- ? ? 5.12366  3.84317 ? ? 3.49406  27.47979 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S   ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
ZN  ? ? 24.64596 5.25405 ? ? 2.14387  29.76375 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . THR   A 1 3   ? 33.94754 -46.17150 -9.11239  1.000 59.10540 ?  537  THR   A N   1 
ATOM   2    C  CA  . THR   A 1 3   ? 33.88690 -45.57005 -7.78618  1.000 60.04175 ?  537  THR   A CA  1 
ATOM   3    C  C   . THR   A 1 3   ? 35.29353 -45.35574 -7.23709  1.000 59.72772 ?  537  THR   A C   1 
ATOM   4    O  O   . THR   A 1 3   ? 35.49379 -44.59046 -6.29332  1.000 60.05901 ?  537  THR   A O   1 
ATOM   5    C  CB  . THR   A 1 3   ? 33.06089 -46.43512 -6.80929  1.000 60.52816 ?  537  THR   A CB  1 
ATOM   6    O  OG1 . THR   A 1 3   ? 32.51455 -45.60557 -5.77604  1.000 63.22234 ?  537  THR   A OG1 1 
ATOM   7    C  CG2 . THR   A 1 3   ? 33.91844 -47.52813 -6.18697  1.000 56.03010 ?  537  THR   A CG2 1 
ATOM   8    N  N   . ARG   A 1 4   ? 36.26910 -46.04261 -7.83646  1.000 61.76631 ?  538  ARG   A N   1 
ATOM   9    C  CA  . ARG   A 1 4   ? 37.66431 -45.76082 -7.52013  1.000 53.54684 ?  538  ARG   A CA  1 
ATOM   10   C  C   . ARG   A 1 4   ? 38.08147 -44.41129 -8.08721  1.000 55.86020 ?  538  ARG   A C   1 
ATOM   11   O  O   . ARG   A 1 4   ? 38.82203 -43.65880 -7.44324  1.000 54.44156 ?  538  ARG   A O   1 
ATOM   12   C  CB  . ARG   A 1 4   ? 38.56255 -46.87210 -8.06460  1.000 54.89092 ?  538  ARG   A CB  1 
ATOM   13   C  CG  . ARG   A 1 4   ? 38.36053 -47.15890 -9.54673  1.000 61.49934 ?  538  ARG   A CG  1 
ATOM   14   C  CD  . ARG   A 1 4   ? 38.10681 -48.62998 -9.81585  1.000 67.02995 ?  538  ARG   A CD  1 
ATOM   15   N  NE  . ARG   A 1 4   ? 36.88417 -49.10187 -9.17854  1.000 70.01010 ?  538  ARG   A NE  1 
ATOM   16   C  CZ  . ARG   A 1 4   ? 36.41049 -50.33454 -9.29441  1.000 71.10788 ?  538  ARG   A CZ  1 
ATOM   17   N  NH1 . ARG   A 1 4   ? 37.02381 -51.24345 -10.03481 1.000 71.42749 ?  538  ARG   A NH1 1 
ATOM   18   N  NH2 . ARG   A 1 4   ? 35.29253 -50.66294 -8.65350  1.000 69.51303 ?  538  ARG   A NH2 1 
ATOM   19   N  N   . GLU   A 1 5   ? 37.59616 -44.08581 -9.28671  1.000 59.91884 ?  539  GLU   A N   1 
ATOM   20   C  CA  . GLU   A 1 5   ? 37.94064 -42.82226 -9.92683  1.000 50.99758 ?  539  GLU   A CA  1 
ATOM   21   C  C   . GLU   A 1 5   ? 37.34079 -41.64193 -9.17527  1.000 52.62997 ?  539  GLU   A C   1 
ATOM   22   O  O   . GLU   A 1 5   ? 37.96464 -40.57858 -9.07771  1.000 52.80688 ?  539  GLU   A O   1 
ATOM   23   C  CB  . GLU   A 1 5   ? 37.45995 -42.83994 -11.37656 1.000 47.37545 ?  539  GLU   A CB  1 
ATOM   24   C  CG  . GLU   A 1 5   ? 38.00147 -41.72739 -12.24797 1.000 47.52805 ?  539  GLU   A CG  1 
ATOM   25   C  CD  . GLU   A 1 5   ? 37.97315 -42.09178 -13.71940 1.000 43.74435 ?  539  GLU   A CD  1 
ATOM   26   O  OE1 . GLU   A 1 5   ? 37.45767 -43.18072 -14.05051 1.000 40.51095 ?  539  GLU   A OE1 1 
ATOM   27   O  OE2 . GLU   A 1 5   ? 38.45916 -41.28944 -14.54404 1.000 41.61175 ?  539  GLU   A OE2 1 
ATOM   28   N  N   . LEU   A 1 6   ? 36.12747 -41.81094 -8.64374  1.000 53.06449 ?  540  LEU   A N   1 
ATOM   29   C  CA  . LEU   A 1 6   ? 35.50662 -40.75414 -7.85242  1.000 50.41628 ?  540  LEU   A CA  1 
ATOM   30   C  C   . LEU   A 1 6   ? 36.35246 -40.41844 -6.63087  1.000 52.89353 ?  540  LEU   A C   1 
ATOM   31   O  O   . LEU   A 1 6   ? 36.48354 -39.24588 -6.26041  1.000 52.65474 ?  540  LEU   A O   1 
ATOM   32   C  CB  . LEU   A 1 6   ? 34.09592 -41.17847 -7.43488  1.000 51.57664 ?  540  LEU   A CB  1 
ATOM   33   C  CG  . LEU   A 1 6   ? 33.05738 -40.11011 -7.07320  1.000 48.49479 ?  540  LEU   A CG  1 
ATOM   34   C  CD1 . LEU   A 1 6   ? 33.27518 -39.54755 -5.67183  1.000 51.00106 ?  540  LEU   A CD1 1 
ATOM   35   C  CD2 . LEU   A 1 6   ? 33.05539 -38.99624 -8.10474  1.000 47.38327 ?  540  LEU   A CD2 1 
ATOM   36   N  N   . GLN   A 1 7   ? 36.94577 -41.43660 -6.00328  1.000 53.16784 ?  541  GLN   A N   1 
ATOM   37   C  CA  . GLN   A 1 7   ? 37.72190 -41.23040 -4.78397  1.000 50.76008 ?  541  GLN   A CA  1 
ATOM   38   C  C   . GLN   A 1 7   ? 38.85813 -40.23930 -5.01075  1.000 51.86732 ?  541  GLN   A C   1 
ATOM   39   O  O   . GLN   A 1 7   ? 38.94273 -39.20387 -4.34077  1.000 42.94899 ?  541  GLN   A O   1 
ATOM   40   C  CB  . GLN   A 1 7   ? 38.26548 -42.57190 -4.29021  1.000 48.72061 ?  541  GLN   A CB  1 
ATOM   41   C  CG  . GLN   A 1 7   ? 38.37332 -42.69909 -2.78079  1.000 59.07651 ?  541  GLN   A CG  1 
ATOM   42   C  CD  . GLN   A 1 7   ? 38.61564 -44.13041 -2.34374  1.000 61.80795 ?  541  GLN   A CD  1 
ATOM   43   O  OE1 . GLN   A 1 7   ? 38.60340 -45.04917 -3.16279  1.000 64.37476 ?  541  GLN   A OE1 1 
ATOM   44   N  NE2 . GLN   A 1 7   ? 38.84441 -44.32687 -1.04998  1.000 56.62164 ?  541  GLN   A NE2 1 
ATOM   45   N  N   . SER   A 1 8   ? 39.74158 -40.53951 -5.96422  1.000 53.16106 ?  542  SER   A N   1 
ATOM   46   C  CA  . SER   A 1 8   ? 40.92077 -39.70892 -6.17559  1.000 51.70062 ?  542  SER   A CA  1 
ATOM   47   C  C   . SER   A 1 8   ? 40.58306 -38.34294 -6.76030  1.000 51.63957 ?  542  SER   A C   1 
ATOM   48   O  O   . SER   A 1 8   ? 41.36434 -37.40117 -6.58669  1.000 47.39220 ?  542  SER   A O   1 
ATOM   49   C  CB  . SER   A 1 8   ? 41.91209 -40.43737 -7.08220  1.000 49.40468 ?  542  SER   A CB  1 
ATOM   50   O  OG  . SER   A 1 8   ? 41.24054 -41.35183 -7.93081  1.000 53.18943 ?  542  SER   A OG  1 
ATOM   51   N  N   . LEU   A 1 9   ? 39.44612 -38.20825 -7.44628  1.000 53.74387 ?  543  LEU   A N   1 
ATOM   52   C  CA  . LEU   A 1 9   ? 39.07135 -36.90381 -7.98156  1.000 50.76555 ?  543  LEU   A CA  1 
ATOM   53   C  C   . LEU   A 1 9   ? 38.36294 -36.05160 -6.93514  1.000 46.22227 ?  543  LEU   A C   1 
ATOM   54   O  O   . LEU   A 1 9   ? 38.66349 -34.85997 -6.79672  1.000 43.74234 ?  543  LEU   A O   1 
ATOM   55   C  CB  . LEU   A 1 9   ? 38.18911 -37.06994 -9.21899  1.000 46.76378 ?  543  LEU   A CB  1 
ATOM   56   C  CG  . LEU   A 1 9   ? 37.47680 -35.79324 -9.67385  1.000 41.68864 ?  543  LEU   A CG  1 
ATOM   57   C  CD1 . LEU   A 1 9   ? 38.47370 -34.73342 -10.12838 1.000 35.83503 ?  543  LEU   A CD1 1 
ATOM   58   C  CD2 . LEU   A 1 9   ? 36.46780 -36.09846 -10.76406 1.000 35.86609 ?  543  LEU   A CD2 1 
ATOM   59   N  N   . ALA   A 1 10  ? 37.42775 -36.64361 -6.18613  1.000 50.78978 ?  544  ALA   A N   1 
ATOM   60   C  CA  . ALA   A 1 10  ? 36.68909 -35.89001 -5.17758  1.000 51.31782 ?  544  ALA   A CA  1 
ATOM   61   C  C   . ALA   A 1 10  ? 37.58899 -35.34047 -4.07788  1.000 48.73368 ?  544  ALA   A C   1 
ATOM   62   O  O   . ALA   A 1 10  ? 37.23375 -34.33585 -3.45316  1.000 49.92985 ?  544  ALA   A O   1 
ATOM   63   C  CB  . ALA   A 1 10  ? 35.59175 -36.76159 -4.56386  1.000 48.31548 ?  544  ALA   A CB  1 
ATOM   64   N  N   . ALA   A 1 11  ? 38.74359 -35.96083 -3.83393  1.000 40.64248 ?  545  ALA   A N   1 
ATOM   65   C  CA  . ALA   A 1 11  ? 39.66390 -35.50593 -2.79722  1.000 43.53074 ?  545  ALA   A CA  1 
ATOM   66   C  C   . ALA   A 1 11  ? 40.62645 -34.42849 -3.28669  1.000 54.94055 ?  545  ALA   A C   1 
ATOM   67   O  O   . ALA   A 1 11  ? 40.92921 -33.49341 -2.53857  1.000 55.26132 ?  545  ALA   A O   1 
ATOM   68   C  CB  . ALA   A 1 11  ? 40.45901 -36.69080 -2.24705  1.000 43.89608 ?  545  ALA   A CB  1 
ATOM   69   N  N   . ALA   A 1 12  ? 41.08888 -34.53480 -4.53204  1.000 56.81098 ?  546  ALA   A N   1 
ATOM   70   C  CA  . ALA   A 1 12  ? 42.15460 -33.68202 -5.05053  1.000 46.04975 ?  546  ALA   A CA  1 
ATOM   71   C  C   . ALA   A 1 12  ? 41.80665 -32.20084 -4.95817  1.000 45.64933 ?  546  ALA   A C   1 
ATOM   72   O  O   . ALA   A 1 12  ? 40.64570 -31.80416 -5.06932  1.000 50.19170 ?  546  ALA   A O   1 
ATOM   73   C  CB  . ALA   A 1 12  ? 42.45368 -34.04341 -6.50563  1.000 48.50771 ?  546  ALA   A CB  1 
ATOM   74   N  N   . VAL   A 1 13  ? 42.83737 -31.38028 -4.76275  1.000 53.24751 ?  547  VAL   A N   1 
ATOM   75   C  CA  . VAL   A 1 13  ? 42.67576 -29.93095 -4.77289  1.000 50.72755 ?  547  VAL   A CA  1 
ATOM   76   C  C   . VAL   A 1 13  ? 42.65723 -29.45362 -6.21783  1.000 43.59632 ?  547  VAL   A C   1 
ATOM   77   O  O   . VAL   A 1 13  ? 43.56080 -29.76992 -7.00024  1.000 39.18934 ?  547  VAL   A O   1 
ATOM   78   C  CB  . VAL   A 1 13  ? 43.79840 -29.25027 -3.97264  1.000 45.99608 ?  547  VAL   A CB  1 
ATOM   79   C  CG1 . VAL   A 1 13  ? 43.77659 -27.73967 -4.18416  1.000 43.93442 ?  547  VAL   A CG1 1 
ATOM   80   C  CG2 . VAL   A 1 13  ? 43.66835 -29.58429 -2.50144  1.000 44.12353 ?  547  VAL   A CG2 1 
ATOM   81   N  N   . VAL   A 1 14  ? 41.61956 -28.70668 -6.58061  1.000 45.38886 ?  548  VAL   A N   1 
ATOM   82   C  CA  . VAL   A 1 14  ? 41.46918 -28.20902 -7.94550  1.000 46.62199 ?  548  VAL   A CA  1 
ATOM   83   C  C   . VAL   A 1 14  ? 42.36853 -26.99160 -8.11875  1.000 42.33524 ?  548  VAL   A C   1 
ATOM   84   O  O   . VAL   A 1 14  ? 42.12709 -25.95138 -7.48853  1.000 41.23183 ?  548  VAL   A O   1 
ATOM   85   C  CB  . VAL   A 1 14  ? 40.00397 -27.87135 -8.26088  1.000 33.09102 ?  548  VAL   A CB  1 
ATOM   86   C  CG1 . VAL   A 1 14  ? 39.86805 -27.39757 -9.69706  1.000 31.04604 ?  548  VAL   A CG1 1 
ATOM   87   C  CG2 . VAL   A 1 14  ? 39.11837 -29.07984 -8.00624  1.000 34.96123 ?  548  VAL   A CG2 1 
ATOM   88   N  N   . PRO   A 1 15  ? 43.41003 -27.07317 -8.94604  1.000 37.87525 ?  549  PRO   A N   1 
ATOM   89   C  CA  . PRO   A 1 15  ? 44.32438 -25.93616 -9.10348  1.000 33.36962 ?  549  PRO   A CA  1 
ATOM   90   C  C   . PRO   A 1 15  ? 43.61322 -24.73132 -9.69849  1.000 38.97368 ?  549  PRO   A C   1 
ATOM   91   O  O   . PRO   A 1 15  ? 42.49337 -24.81337 -10.20675 1.000 42.68332 ?  549  PRO   A O   1 
ATOM   92   C  CB  . PRO   A 1 15  ? 45.40887 -26.47362 -10.04554 1.000 33.49459 ?  549  PRO   A CB  1 
ATOM   93   C  CG  . PRO   A 1 15  ? 45.30212 -27.96703 -9.94663  1.000 32.02339 ?  549  PRO   A CG  1 
ATOM   94   C  CD  . PRO   A 1 15  ? 43.84701 -28.24374 -9.72454  1.000 37.98719 ?  549  PRO   A CD  1 
ATOM   95   N  N   . SER   A 1 16  ? 44.28823 -23.58765 -9.62310  1.000 38.22115 ?  550  SER   A N   1 
ATOM   96   C  CA  . SER   A 1 16  ? 43.72860 -22.35136 -10.14556 1.000 33.13307 ?  550  SER   A CA  1 
ATOM   97   C  C   . SER   A 1 16  ? 43.52333 -22.44681 -11.65492 1.000 38.88210 ?  550  SER   A C   1 
ATOM   98   O  O   . SER   A 1 16  ? 44.12806 -23.27255 -12.34344 1.000 36.49792 ?  550  SER   A O   1 
ATOM   99   C  CB  . SER   A 1 16  ? 44.64376 -21.17234 -9.81792  1.000 44.00184 ?  550  SER   A CB  1 
ATOM   100  O  OG  . SER   A 1 16  ? 44.45991 -20.11141 -10.73895 1.000 46.42534 ?  550  SER   A OG  1 
ATOM   101  N  N   . ALA   A 1 17  ? 42.64351 -21.58215 -12.16674 1.000 45.85177 ?  551  ALA   A N   1 
ATOM   102  C  CA  . ALA   A 1 17  ? 42.43823 -21.50140 -13.60866 1.000 40.88185 ?  551  ALA   A CA  1 
ATOM   103  C  C   . ALA   A 1 17  ? 43.72230 -21.12345 -14.33296 1.000 48.54713 ?  551  ALA   A C   1 
ATOM   104  O  O   . ALA   A 1 17  ? 43.96376 -21.58484 -15.45515 1.000 49.79511 ?  551  ALA   A O   1 
ATOM   105  C  CB  . ALA   A 1 17  ? 41.33370 -20.49390 -13.92405 1.000 40.35073 ?  551  ALA   A CB  1 
ATOM   106  N  N   . GLN   A 1 18  ? 44.56075 -20.30038 -13.70165 1.000 55.56955 ?  552  GLN   A N   1 
ATOM   107  C  CA  . GLN   A 1 18  ? 45.80352 -19.87169 -14.33202 1.000 46.06692 ?  552  GLN   A CA  1 
ATOM   108  C  C   . GLN   A 1 18  ? 46.82144 -21.00441 -14.37569 1.000 47.75029 ?  552  GLN   A C   1 
ATOM   109  O  O   . GLN   A 1 18  ? 47.58527 -21.12210 -15.34088 1.000 46.02255 ?  552  GLN   A O   1 
ATOM   110  C  CB  . GLN   A 1 18  ? 46.36668 -18.66037 -13.59060 1.000 49.98318 ?  552  GLN   A CB  1 
ATOM   111  C  CG  . GLN   A 1 18  ? 47.20210 -17.73592 -14.45564 1.000 46.99542 ?  552  GLN   A CG  1 
ATOM   112  C  CD  . GLN   A 1 18  ? 48.21654 -16.94435 -13.65365 1.000 58.23616 ?  552  GLN   A CD  1 
ATOM   113  O  OE1 . GLN   A 1 18  ? 48.33995 -17.11630 -12.44036 1.000 55.61752 ?  552  GLN   A OE1 1 
ATOM   114  N  NE2 . GLN   A 1 18  ? 48.94428 -16.06321 -14.32924 1.000 65.76076 ?  552  GLN   A NE2 1 
ATOM   115  N  N   . THR   A 1 19  ? 46.85036 -21.84552 -13.33891 1.000 48.09757 ?  553  THR   A N   1 
ATOM   116  C  CA  . THR   A 1 19  ? 47.72493 -23.01351 -13.36307 1.000 43.98782 ?  553  THR   A CA  1 
ATOM   117  C  C   . THR   A 1 19  ? 47.30915 -23.98048 -14.46465 1.000 48.84850 ?  553  THR   A C   1 
ATOM   118  O  O   . THR   A 1 19  ? 48.15952 -24.55433 -15.15561 1.000 50.13540 ?  553  THR   A O   1 
ATOM   119  C  CB  . THR   A 1 19  ? 47.70966 -23.71642 -12.00361 1.000 42.44809 ?  553  THR   A CB  1 
ATOM   120  O  OG1 . THR   A 1 19  ? 47.87614 -22.75346 -10.95448 1.000 43.78903 ?  553  THR   A OG1 1 
ATOM   121  C  CG2 . THR   A 1 19  ? 48.82157 -24.75366 -11.92565 1.000 34.58320 ?  553  THR   A CG2 1 
ATOM   122  N  N   . LEU   A 1 20  ? 46.00184 -24.15947 -14.65267 1.000 50.26536 ?  554  LEU   A N   1 
ATOM   123  C  CA  . LEU   A 1 20  ? 45.47957 -25.08623 -15.64649 1.000 43.59774 ?  554  LEU   A CA  1 
ATOM   124  C  C   . LEU   A 1 20  ? 45.40444 -24.48349 -17.04560 1.000 39.11432 ?  554  LEU   A C   1 
ATOM   125  O  O   . LEU   A 1 20  ? 45.11843 -25.21523 -17.99849 1.000 39.91244 ?  554  LEU   A O   1 
ATOM   126  C  CB  . LEU   A 1 20  ? 44.09612 -25.57732 -15.21297 1.000 40.86421 ?  554  LEU   A CB  1 
ATOM   127  C  CG  . LEU   A 1 20  ? 44.03286 -26.20572 -13.81601 1.000 37.75101 ?  554  LEU   A CG  1 
ATOM   128  C  CD1 . LEU   A 1 20  ? 42.61236 -26.18224 -13.27194 1.000 34.78105 ?  554  LEU   A CD1 1 
ATOM   129  C  CD2 . LEU   A 1 20  ? 44.58290 -27.62561 -13.82084 1.000 33.66160 ?  554  LEU   A CD2 1 
ATOM   130  N  N   . LYS   A 1 21  ? 45.64668 -23.17870 -17.18633 1.000 38.42746 ?  555  LYS   A N   1 
ATOM   131  C  CA  . LYS   A 1 21  ? 45.73968 -22.49304 -18.47739 1.000 43.46352 ?  555  LYS   A CA  1 
ATOM   132  C  C   . LYS   A 1 21  ? 44.43917 -22.53746 -19.27867 1.000 40.59616 ?  555  LYS   A C   1 
ATOM   133  O  O   . LYS   A 1 21  ? 44.45069 -22.29704 -20.48900 1.000 37.00502 ?  555  LYS   A O   1 
ATOM   134  C  CB  . LYS   A 1 21  ? 46.88341 -23.05631 -19.33821 1.000 38.17500 ?  555  LYS   A CB  1 
ATOM   135  C  CG  . LYS   A 1 21  ? 48.14250 -23.46027 -18.58949 1.000 34.24328 ?  555  LYS   A CG  1 
ATOM   136  C  CD  . LYS   A 1 21  ? 49.22581 -23.90635 -19.56186 1.000 36.39805 ?  555  LYS   A CD  1 
ATOM   137  C  CE  . LYS   A 1 21  ? 49.69065 -25.32061 -19.26294 1.000 36.51800 ?  555  LYS   A CE  1 
ATOM   138  N  NZ  . LYS   A 1 21  ? 50.34391 -25.42010 -17.93256 1.000 41.61008 ?  555  LYS   A NZ  1 
ATOM   139  N  N   . ILE   A 1 22  ? 43.30257 -22.81945 -18.64475 1.000 41.67833 ?  556  ILE   A N   1 
ATOM   140  C  CA  . ILE   A 1 22  ? 42.05647 -22.98914 -19.38711 1.000 38.22321 ?  556  ILE   A CA  1 
ATOM   141  C  C   . ILE   A 1 22  ? 41.46537 -21.63989 -19.78140 1.000 37.18389 ?  556  ILE   A C   1 
ATOM   142  O  O   . ILE   A 1 22  ? 40.33272 -21.56832 -20.27277 1.000 37.64196 ?  556  ILE   A O   1 
ATOM   143  C  CB  . ILE   A 1 22  ? 41.03802 -23.81512 -18.58346 1.000 36.03883 ?  556  ILE   A CB  1 
ATOM   144  C  CG1 . ILE   A 1 22  ? 40.69865 -23.11341 -17.26998 1.000 35.29028 ?  556  ILE   A CG1 1 
ATOM   145  C  CG2 . ILE   A 1 22  ? 41.58448 -25.20489 -18.32042 1.000 36.96600 ?  556  ILE   A CG2 1 
ATOM   146  C  CD1 . ILE   A 1 22  ? 39.86594 -23.95938 -16.35398 1.000 27.11830 ?  556  ILE   A CD1 1 
ATOM   147  N  N   . THR   A 1 23  ? 42.22330 -20.56325 -19.57835 1.000 39.49993 ?  557  THR   A N   1 
ATOM   148  C  CA  . THR   A 1 23  ? 41.79393 -19.24104 -20.01394 1.000 36.10826 ?  557  THR   A CA  1 
ATOM   149  C  C   . THR   A 1 23  ? 42.30594 -18.89082 -21.40464 1.000 35.04779 ?  557  THR   A C   1 
ATOM   150  O  O   . THR   A 1 23  ? 41.66796 -18.09590 -22.10571 1.000 36.70777 ?  557  THR   A O   1 
ATOM   151  C  CB  . THR   A 1 23  ? 42.24867 -18.18237 -18.99834 1.000 41.15888 ?  557  THR   A CB  1 
ATOM   152  O  OG1 . THR   A 1 23  ? 41.74648 -18.53197 -17.70408 1.000 50.29794 ?  557  THR   A OG1 1 
ATOM   153  C  CG2 . THR   A 1 23  ? 41.71874 -16.79908 -19.36298 1.000 39.61628 ?  557  THR   A CG2 1 
ATOM   154  N  N   . ASP   A 1 24  ? 43.41855 -19.48570 -21.82842 1.000 41.31758 ?  558  ASP   A N   1 
ATOM   155  C  CA  . ASP   A 1 24  ? 43.95878 -19.21715 -23.15329 1.000 40.58227 ?  558  ASP   A CA  1 
ATOM   156  C  C   . ASP   A 1 24  ? 43.05047 -19.79888 -24.22787 1.000 36.53642 ?  558  ASP   A C   1 
ATOM   157  O  O   . ASP   A 1 24  ? 42.62185 -20.95333 -24.13658 1.000 35.05167 ?  558  ASP   A O   1 
ATOM   158  C  CB  . ASP   A 1 24  ? 45.36318 -19.80811 -23.28980 1.000 39.34361 ?  558  ASP   A CB  1 
ATOM   159  C  CG  . ASP   A 1 24  ? 46.19071 -19.65651 -22.02945 1.000 49.12929 ?  558  ASP   A CG  1 
ATOM   160  O  OD1 . ASP   A 1 24  ? 46.05254 -18.62254 -21.34268 1.000 55.01910 ?  558  ASP   A OD1 1 
ATOM   161  O  OD2 . ASP   A 1 24  ? 46.98298 -20.57414 -21.72757 1.000 49.99716 ?  558  ASP   A OD2 1 
ATOM   162  N  N   . PHE   A 1 25  ? 42.75115 -18.99107 -25.24804 1.000 32.02003 ?  559  PHE   A N   1 
ATOM   163  C  CA  . PHE   A 1 25  ? 42.16207 -19.54135 -26.46230 1.000 30.10345 ?  559  PHE   A CA  1 
ATOM   164  C  C   . PHE   A 1 25  ? 43.09287 -20.56562 -27.09516 1.000 28.78681 ?  559  PHE   A C   1 
ATOM   165  O  O   . PHE   A 1 25  ? 42.63528 -21.49128 -27.77463 1.000 31.35149 ?  559  PHE   A O   1 
ATOM   166  C  CB  . PHE   A 1 25  ? 41.85758 -18.42096 -27.45847 1.000 31.80274 ?  559  PHE   A CB  1 
ATOM   167  C  CG  . PHE   A 1 25  ? 40.75730 -17.49421 -27.02187 1.000 37.42684 ?  559  PHE   A CG  1 
ATOM   168  C  CD1 . PHE   A 1 25  ? 39.43168 -17.90024 -27.05533 1.000 34.71429 ?  559  PHE   A CD1 1 
ATOM   169  C  CD2 . PHE   A 1 25  ? 41.04925 -16.21265 -26.58662 1.000 35.30653 ?  559  PHE   A CD2 1 
ATOM   170  C  CE1 . PHE   A 1 25  ? 38.41816 -17.04410 -26.65807 1.000 31.55968 ?  559  PHE   A CE1 1 
ATOM   171  C  CE2 . PHE   A 1 25  ? 40.04325 -15.35232 -26.18771 1.000 40.60664 ?  559  PHE   A CE2 1 
ATOM   172  C  CZ  . PHE   A 1 25  ? 38.72533 -15.76807 -26.22306 1.000 39.90305 ?  559  PHE   A CZ  1 
ATOM   173  N  N   . SER   A 1 26  ? 44.39894 -20.41958 -26.86987 1.000 35.49900 ?  560  SER   A N   1 
ATOM   174  C  CA  . SER   A 1 26  ? 45.41948 -21.29192 -27.43088 1.000 37.10037 ?  560  SER   A CA  1 
ATOM   175  C  C   . SER   A 1 26  ? 45.69674 -22.51266 -26.55800 1.000 30.71372 ?  560  SER   A C   1 
ATOM   176  O  O   . SER   A 1 26  ? 46.79567 -23.07544 -26.62420 1.000 30.98561 ?  560  SER   A O   1 
ATOM   177  C  CB  . SER   A 1 26  ? 46.71079 -20.50127 -27.64999 1.000 37.75028 ?  560  SER   A CB  1 
ATOM   178  O  OG  . SER   A 1 26  ? 46.78701 -19.40326 -26.75532 1.000 46.64651 ?  560  SER   A OG  1 
ATOM   179  N  N   . PHE   A 1 27  ? 44.72909 -22.93031 -25.74776 1.000 31.26554 ?  561  PHE   A N   1 
ATOM   180  C  CA  . PHE   A 1 27  ? 44.91611 -24.03638 -24.82178 1.000 31.65446 ?  561  PHE   A CA  1 
ATOM   181  C  C   . PHE   A 1 27  ? 44.85180 -25.36746 -25.56438 1.000 35.00323 ?  561  PHE   A C   1 
ATOM   182  O  O   . PHE   A 1 27  ? 44.19720 -25.49188 -26.60359 1.000 32.52608 ?  561  PHE   A O   1 
ATOM   183  C  CB  . PHE   A 1 27  ? 43.85543 -23.95851 -23.71478 1.000 32.23123 ?  561  PHE   A CB  1 
ATOM   184  C  CG  . PHE   A 1 27  ? 43.55175 -25.27075 -23.03444 1.000 33.99630 ?  561  PHE   A CG  1 
ATOM   185  C  CD1 . PHE   A 1 27  ? 42.65319 -26.17705 -23.58522 1.000 29.65163 ?  561  PHE   A CD1 1 
ATOM   186  C  CD2 . PHE   A 1 27  ? 44.14147 -25.57986 -21.82074 1.000 34.71004 ?  561  PHE   A CD2 1 
ATOM   187  C  CE1 . PHE   A 1 27  ? 42.37288 -27.37181 -22.95018 1.000 29.58636 ?  561  PHE   A CE1 1 
ATOM   188  C  CE2 . PHE   A 1 27  ? 43.86343 -26.77121 -21.18046 1.000 34.67626 ?  561  PHE   A CE2 1 
ATOM   189  C  CZ  . PHE   A 1 27  ? 42.97846 -27.66842 -21.74526 1.000 32.89250 ?  561  PHE   A CZ  1 
ATOM   190  N  N   . SER   A 1 28  ? 45.55012 -26.36690 -25.02347 1.000 29.33323 ?  562  SER   A N   1 
ATOM   191  C  CA  . SER   A 1 28  ? 45.51329 -27.71933 -25.56308 1.000 28.68949 ?  562  SER   A CA  1 
ATOM   192  C  C   . SER   A 1 28  ? 45.46027 -28.71904 -24.41452 1.000 34.29628 ?  562  SER   A C   1 
ATOM   193  O  O   . SER   A 1 28  ? 45.76277 -28.39293 -23.26361 1.000 40.28045 ?  562  SER   A O   1 
ATOM   194  C  CB  . SER   A 1 28  ? 46.71630 -28.00810 -26.46763 1.000 28.82490 ?  562  SER   A CB  1 
ATOM   195  O  OG  . SER   A 1 28  ? 46.58727 -29.27842 -27.08212 1.000 32.77735 ?  562  SER   A OG  1 
ATOM   196  N  N   . ASP   A 1 29  ? 45.08298 -29.95572 -24.74790 1.000 35.91724 ?  563  ASP   A N   1 
ATOM   197  C  CA  . ASP   A 1 29  ? 44.76181 -30.97230 -23.75454 1.000 32.65903 ?  563  ASP   A CA  1 
ATOM   198  C  C   . ASP   A 1 29  ? 45.56975 -32.25624 -23.88276 1.000 37.07222 ?  563  ASP   A C   1 
ATOM   199  O  O   . ASP   A 1 29  ? 45.37411 -33.16720 -23.06904 1.000 38.53678 ?  563  ASP   A O   1 
ATOM   200  C  CB  . ASP   A 1 29  ? 43.27250 -31.32973 -23.83393 1.000 30.28739 ?  563  ASP   A CB  1 
ATOM   201  C  CG  . ASP   A 1 29  ? 42.94730 -32.18366 -25.04709 1.000 35.51310 ?  563  ASP   A CG  1 
ATOM   202  O  OD1 . ASP   A 1 29  ? 42.88261 -31.63404 -26.16743 1.000 34.86678 ?  563  ASP   A OD1 1 
ATOM   203  O  OD2 . ASP   A 1 29  ? 42.77217 -33.40865 -24.88296 1.000 37.27352 ?  563  ASP   A OD2 1 
ATOM   204  N  N   . PHE   A 1 30  ? 46.45514 -32.36643 -24.87808 1.000 32.44347 ?  564  PHE   A N   1 
ATOM   205  C  CA  . PHE   A 1 30  ? 47.14756 -33.63110 -25.11867 1.000 30.48921 ?  564  PHE   A CA  1 
ATOM   206  C  C   . PHE   A 1 30  ? 47.93389 -34.08366 -23.89541 1.000 37.77008 ?  564  PHE   A C   1 
ATOM   207  O  O   . PHE   A 1 30  ? 47.89907 -35.26373 -23.52646 1.000 41.36007 ?  564  PHE   A O   1 
ATOM   208  C  CB  . PHE   A 1 30  ? 48.08272 -33.50460 -26.31977 1.000 32.35040 ?  564  PHE   A CB  1 
ATOM   209  C  CG  . PHE   A 1 30  ? 47.38225 -33.20432 -27.60977 1.000 34.09418 ?  564  PHE   A CG  1 
ATOM   210  C  CD1 . PHE   A 1 30  ? 46.15411 -33.77354 -27.89867 1.000 36.95285 ?  564  PHE   A CD1 1 
ATOM   211  C  CD2 . PHE   A 1 30  ? 47.96062 -32.35900 -28.54075 1.000 40.60810 ?  564  PHE   A CD2 1 
ATOM   212  C  CE1 . PHE   A 1 30  ? 45.51488 -33.49891 -29.09028 1.000 34.79501 ?  564  PHE   A CE1 1 
ATOM   213  C  CE2 . PHE   A 1 30  ? 47.32629 -32.08150 -29.73223 1.000 29.22284 ?  564  PHE   A CE2 1 
ATOM   214  C  CZ  . PHE   A 1 30  ? 46.10421 -32.65262 -30.00762 1.000 31.99715 ?  564  PHE   A CZ  1 
ATOM   215  N  N   . GLU   A 1 31  ? 48.65077 -33.15971 -23.25467 1.000 38.13664 ?  565  GLU   A N   1 
ATOM   216  C  CA  . GLU   A 1 31  ? 49.48425 -33.51508 -22.11397 1.000 34.81588 ?  565  GLU   A CA  1 
ATOM   217  C  C   . GLU   A 1 31  ? 48.66908 -33.98122 -20.91553 1.000 37.41620 ?  565  GLU   A C   1 
ATOM   218  O  O   . GLU   A 1 31  ? 49.21145 -34.66727 -20.04334 1.000 40.76931 ?  565  GLU   A O   1 
ATOM   219  C  CB  . GLU   A 1 31  ? 50.34897 -32.32112 -21.71277 1.000 33.77804 ?  565  GLU   A CB  1 
ATOM   220  C  CG  . GLU   A 1 31  ? 49.55974 -31.15722 -21.13246 1.000 34.44046 ?  565  GLU   A CG  1 
ATOM   221  C  CD  . GLU   A 1 31  ? 49.42568 -29.99553 -22.09856 1.000 40.46940 ?  565  GLU   A CD  1 
ATOM   222  O  OE1 . GLU   A 1 31  ? 49.33789 -30.23973 -23.32108 1.000 37.58602 ?  565  GLU   A OE1 1 
ATOM   223  O  OE2 . GLU   A 1 31  ? 49.40239 -28.83640 -21.63387 1.000 44.81738 ?  565  GLU   A OE2 1 
ATOM   224  N  N   . LEU   A 1 32  ? 47.38635 -33.63810 -20.85653 1.000 36.83272 ?  566  LEU   A N   1 
ATOM   225  C  CA  . LEU   A 1 32  ? 46.58903 -33.90236 -19.66964 1.000 32.26534 ?  566  LEU   A CA  1 
ATOM   226  C  C   . LEU   A 1 32  ? 46.07387 -35.33486 -19.65645 1.000 37.51011 ?  566  LEU   A C   1 
ATOM   227  O  O   . LEU   A 1 32  ? 45.68858 -35.88630 -20.69249 1.000 41.12929 ?  566  LEU   A O   1 
ATOM   228  C  CB  . LEU   A 1 32  ? 45.41246 -32.92972 -19.59326 1.000 35.97022 ?  566  LEU   A CB  1 
ATOM   229  C  CG  . LEU   A 1 32  ? 45.73305 -31.45137 -19.82388 1.000 32.26888 ?  566  LEU   A CG  1 
ATOM   230  C  CD1 . LEU   A 1 32  ? 44.45215 -30.63882 -19.89855 1.000 32.90307 ?  566  LEU   A CD1 1 
ATOM   231  C  CD2 . LEU   A 1 32  ? 46.64443 -30.91271 -18.72992 1.000 32.41745 ?  566  LEU   A CD2 1 
ATOM   232  N  N   . SER   A 1 33  ? 46.07294 -35.93597 -18.46966 1.000 39.62641 ?  567  SER   A N   1 
ATOM   233  C  CA  . SER   A 1 33  ? 45.38859 -37.20011 -18.26224 1.000 37.82817 ?  567  SER   A CA  1 
ATOM   234  C  C   . SER   A 1 33  ? 43.88180 -36.95951 -18.19620 1.000 41.35238 ?  567  SER   A C   1 
ATOM   235  O  O   . SER   A 1 33  ? 43.40009 -35.82808 -18.30807 1.000 42.46431 ?  567  SER   A O   1 
ATOM   236  C  CB  . SER   A 1 33  ? 45.89539 -37.88023 -16.99069 1.000 35.52230 ?  567  SER   A CB  1 
ATOM   237  O  OG  . SER   A 1 33  ? 45.54337 -37.13869 -15.83449 1.000 37.23959 ?  567  SER   A OG  1 
ATOM   238  N  N   . ASP   A 1 34  ? 43.12214 -38.04179 -18.01650 1.000 42.26557 ?  568  ASP   A N   1 
ATOM   239  C  CA  . ASP   A 1 34  ? 41.67541 -37.91076 -17.87873 1.000 34.96823 ?  568  ASP   A CA  1 
ATOM   240  C  C   . ASP   A 1 34  ? 41.31390 -37.15353 -16.60610 1.000 35.60608 ?  568  ASP   A C   1 
ATOM   241  O  O   . ASP   A 1 34  ? 40.48285 -36.23791 -16.63146 1.000 42.63855 ?  568  ASP   A O   1 
ATOM   242  C  CB  . ASP   A 1 34  ? 41.01375 -39.29052 -17.89165 1.000 32.08249 ?  568  ASP   A CB  1 
ATOM   243  C  CG  . ASP   A 1 34  ? 40.91915 -39.88412 -19.28733 1.000 41.08384 ?  568  ASP   A CG  1 
ATOM   244  O  OD1 . ASP   A 1 34  ? 40.91208 -39.11030 -20.26834 1.000 37.96531 ?  568  ASP   A OD1 1 
ATOM   245  O  OD2 . ASP   A 1 34  ? 40.83990 -41.12624 -19.40339 1.000 52.12202 ?  568  ASP   A OD2 1 
ATOM   246  N  N   . LEU   A 1 35  ? 41.93936 -37.51610 -15.48224 1.000 30.79297 ?  569  LEU   A N   1 
ATOM   247  C  CA  . LEU   A 1 35  ? 41.64086 -36.85170 -14.21685 1.000 31.50963 ?  569  LEU   A CA  1 
ATOM   248  C  C   . LEU   A 1 35  ? 42.00862 -35.37421 -14.25126 1.000 37.51643 ?  569  LEU   A C   1 
ATOM   249  O  O   . LEU   A 1 35  ? 41.35761 -34.55712 -13.58918 1.000 40.69334 ?  569  LEU   A O   1 
ATOM   250  C  CB  . LEU   A 1 35  ? 42.37136 -37.54843 -13.07039 1.000 35.16258 ?  569  LEU   A CB  1 
ATOM   251  C  CG  . LEU   A 1 35  ? 41.78100 -37.32050 -11.67707 1.000 36.31576 ?  569  LEU   A CG  1 
ATOM   252  C  CD1 . LEU   A 1 35  ? 41.30775 -38.63435 -11.07296 1.000 39.70412 ?  569  LEU   A CD1 1 
ATOM   253  C  CD2 . LEU   A 1 35  ? 42.79167 -36.63868 -10.76667 1.000 33.32292 ?  569  LEU   A CD2 1 
ATOM   254  N  N   . GLU   A 1 36  ? 43.05236 -35.01305 -15.00051 1.000 40.99710 ?  570  GLU   A N   1 
ATOM   255  C  CA  . GLU   A 1 36  ? 43.41534 -33.60552 -15.12362 1.000 38.02730 ?  570  GLU   A CA  1 
ATOM   256  C  C   . GLU   A 1 36  ? 42.33292 -32.81979 -15.85173 1.000 35.01539 ?  570  GLU   A C   1 
ATOM   257  O  O   . GLU   A 1 36  ? 42.04797 -31.67057 -15.49591 1.000 37.50386 ?  570  GLU   A O   1 
ATOM   258  C  CB  . GLU   A 1 36  ? 44.75857 -33.46882 -15.83736 1.000 39.83931 ?  570  GLU   A CB  1 
ATOM   259  C  CG  . GLU   A 1 36  ? 45.94529 -33.84573 -14.96867 1.000 36.37616 ?  570  GLU   A CG  1 
ATOM   260  C  CD  . GLU   A 1 36  ? 47.22258 -34.01660 -15.76184 1.000 42.10229 ?  570  GLU   A CD  1 
ATOM   261  O  OE1 . GLU   A 1 36  ? 47.24969 -34.87318 -16.66830 1.000 41.39157 ?  570  GLU   A OE1 1 
ATOM   262  O  OE2 . GLU   A 1 36  ? 48.20158 -33.29453 -15.47524 1.000 45.68181 ?  570  GLU   A OE2 1 
ATOM   263  N  N   . THR   A 1 37  ? 41.71977 -33.42028 -16.87511 1.000 35.67438 ?  571  THR   A N   1 
ATOM   264  C  CA  . THR   A 1 37  ? 40.59645 -32.76952 -17.54092 1.000 37.70892 ?  571  THR   A CA  1 
ATOM   265  C  C   . THR   A 1 37  ? 39.40716 -32.62171 -16.60265 1.000 33.40827 ?  571  THR   A C   1 
ATOM   266  O  O   . THR   A 1 37  ? 38.60450 -31.69407 -16.75726 1.000 31.32188 ?  571  THR   A O   1 
ATOM   267  C  CB  . THR   A 1 37  ? 40.18721 -33.55661 -18.78607 1.000 35.33547 ?  571  THR   A CB  1 
ATOM   268  O  OG1 . THR   A 1 37  ? 39.82058 -34.88938 -18.40935 1.000 34.40951 ?  571  THR   A OG1 1 
ATOM   269  C  CG2 . THR   A 1 37  ? 41.33162 -33.61489 -19.78276 1.000 31.54228 ?  571  THR   A CG2 1 
ATOM   270  N  N   . ALA   A 1 38  ? 39.27602 -33.52454 -15.62862 1.000 34.19107 ?  572  ALA   A N   1 
ATOM   271  C  CA  . ALA   A 1 38  ? 38.20233 -33.40788 -14.64805 1.000 37.51688 ?  572  ALA   A CA  1 
ATOM   272  C  C   . ALA   A 1 38  ? 38.43648 -32.22251 -13.71882 1.000 33.63016 ?  572  ALA   A C   1 
ATOM   273  O  O   . ALA   A 1 38  ? 37.50863 -31.45897 -13.42545 1.000 31.96100 ?  572  ALA   A O   1 
ATOM   274  C  CB  . ALA   A 1 38  ? 38.07661 -34.70549 -13.85038 1.000 33.63275 ?  572  ALA   A CB  1 
ATOM   275  N  N   . LEU   A 1 39  ? 39.67321 -32.05936 -13.23654 1.000 31.29471 ?  573  LEU   A N   1 
ATOM   276  C  CA  . LEU   A 1 39  ? 40.00072 -30.90008 -12.41123 1.000 31.29245 ?  573  LEU   A CA  1 
ATOM   277  C  C   . LEU   A 1 39  ? 39.76953 -29.60314 -13.17445 1.000 27.68543 ?  573  LEU   A C   1 
ATOM   278  O  O   . LEU   A 1 39  ? 39.23389 -28.63428 -12.62301 1.000 23.96118 ?  573  LEU   A O   1 
ATOM   279  C  CB  . LEU   A 1 39  ? 41.45090 -30.98292 -11.93138 1.000 37.32766 ?  573  LEU   A CB  1 
ATOM   280  C  CG  . LEU   A 1 39  ? 41.86125 -32.14170 -11.02076 1.000 37.54433 ?  573  LEU   A CG  1 
ATOM   281  C  CD1 . LEU   A 1 39  ? 43.34675 -32.06327 -10.69785 1.000 40.93549 ?  573  LEU   A CD1 1 
ATOM   282  C  CD2 . LEU   A 1 39  ? 41.03741 -32.12563 -9.74648  1.000 34.98756 ?  573  LEU   A CD2 1 
ATOM   283  N  N   . CYS   A 1 40  ? 40.16916 -29.56778 -14.44772 1.000 28.89999 ?  574  CYS   A N   1 
ATOM   284  C  CA  . CYS   A 1 40  ? 39.92412 -28.38861 -15.27029 1.000 29.70415 ?  574  CYS   A CA  1 
ATOM   285  C  C   . CYS   A 1 40  ? 38.43072 -28.12511 -15.42319 1.000 32.14381 ?  574  CYS   A C   1 
ATOM   286  O  O   . CYS   A 1 40  ? 37.99945 -26.96730 -15.48230 1.000 32.13257 ?  574  CYS   A O   1 
ATOM   287  C  CB  . CYS   A 1 40  ? 40.58148 -28.56140 -16.64015 1.000 30.91372 ?  574  CYS   A CB  1 
ATOM   288  S  SG  . CYS   A 1 40  ? 42.38440 -28.73308 -16.61637 1.000 33.58576 ?  574  CYS   A SG  1 
ATOM   289  N  N   . THR   A 1 41  ? 37.62459 -29.18870 -15.48362 1.000 31.47246 ?  575  THR   A N   1 
ATOM   290  C  CA  . THR   A 1 41  ? 36.18112 -29.02162 -15.62527 1.000 28.32965 ?  575  THR   A CA  1 
ATOM   291  C  C   . THR   A 1 41  ? 35.57015 -28.43275 -14.35792 1.000 32.80314 ?  575  THR   A C   1 
ATOM   292  O  O   . THR   A 1 41  ? 34.75923 -27.50086 -14.42484 1.000 34.47839 ?  575  THR   A O   1 
ATOM   293  C  CB  . THR   A 1 41  ? 35.52678 -30.36090 -15.96936 1.000 31.25743 ?  575  THR   A CB  1 
ATOM   294  O  OG1 . THR   A 1 41  ? 36.27832 -31.01393 -17.00096 1.000 30.98313 ?  575  THR   A OG1 1 
ATOM   295  C  CG2 . THR   A 1 41  ? 34.10033 -30.14519 -16.45627 1.000 32.53079 ?  575  THR   A CG2 1 
ATOM   296  N  N   . ILE   A 1 42  ? 35.94362 -28.97094 -13.19169 1.000 29.92261 ?  576  ILE   A N   1 
ATOM   297  C  CA  . ILE   A 1 42  ? 35.48751 -28.40289 -11.92463 1.000 28.61435 ?  576  ILE   A CA  1 
ATOM   298  C  C   . ILE   A 1 42  ? 35.88319 -26.93597 -11.83126 1.000 31.81559 ?  576  ILE   A C   1 
ATOM   299  O  O   . ILE   A 1 42  ? 35.07858 -26.08122 -11.43876 1.000 31.93985 ?  576  ILE   A O   1 
ATOM   300  C  CB  . ILE   A 1 42  ? 36.05100 -29.20821 -10.73620 1.000 26.55120 ?  576  ILE   A CB  1 
ATOM   301  C  CG1 . ILE   A 1 42  ? 35.42376 -30.60017 -10.66560 1.000 24.60384 ?  576  ILE   A CG1 1 
ATOM   302  C  CG2 . ILE   A 1 42  ? 35.82014 -28.46444 -9.43017  1.000 25.33075 ?  576  ILE   A CG2 1 
ATOM   303  C  CD1 . ILE   A 1 42  ? 36.32149 -31.64065 -10.02857 1.000 23.28094 ?  576  ILE   A CD1 1 
ATOM   304  N  N   . ARG   A 1 43  ? 37.12766 -26.62326 -12.19976 1.000 29.99753 ?  577  ARG   A N   1 
ATOM   305  C  CA  . ARG   A 1 43  ? 37.60496 -25.24571 -12.14761 1.000 28.08268 ?  577  ARG   A CA  1 
ATOM   306  C  C   . ARG   A 1 43  ? 36.76680 -24.33482 -13.03889 1.000 36.28844 ?  577  ARG   A C   1 
ATOM   307  O  O   . ARG   A 1 43  ? 36.49139 -23.18379 -12.67832 1.000 35.21183 ?  577  ARG   A O   1 
ATOM   308  C  CB  . ARG   A 1 43  ? 39.07940 -25.19974 -12.55287 1.000 25.96054 ?  577  ARG   A CB  1 
ATOM   309  C  CG  . ARG   A 1 43  ? 39.62050 -23.81388 -12.84683 1.000 32.24268 ?  577  ARG   A CG  1 
ATOM   310  C  CD  . ARG   A 1 43  ? 39.58317 -22.92818 -11.61808 1.000 33.75557 ?  577  ARG   A CD  1 
ATOM   311  N  NE  . ARG   A 1 43  ? 40.09618 -23.61551 -10.44002 1.000 36.75753 ?  577  ARG   A NE  1 
ATOM   312  C  CZ  . ARG   A 1 43  ? 39.90266 -23.20613 -9.19459  1.000 27.86526 ?  577  ARG   A CZ  1 
ATOM   313  N  NH1 . ARG   A 1 43  ? 39.22254 -22.10316 -8.92832  1.000 31.21428 ?  577  ARG   A NH1 1 
ATOM   314  N  NH2 . ARG   A 1 43  ? 40.40655 -23.91928 -8.19186  1.000 29.97338 ?  577  ARG   A NH2 1 
ATOM   315  N  N   . MET   A 1 44  ? 36.34468 -24.83512 -14.20376 1.000 36.01880 ?  578  MET   A N   1 
ATOM   316  C  CA  . MET   A 1 44  ? 35.49755 -24.04133 -15.08967 1.000 33.81552 ?  578  MET   A CA  1 
ATOM   317  C  C   . MET   A 1 44  ? 34.18501 -23.68055 -14.40773 1.000 39.75246 ?  578  MET   A C   1 
ATOM   318  O  O   . MET   A 1 44  ? 33.79855 -22.50669 -14.35968 1.000 38.44387 ?  578  MET   A O   1 
ATOM   319  C  CB  . MET   A 1 44  ? 35.23511 -24.80330 -16.38736 1.000 37.60320 ?  578  MET   A CB  1 
ATOM   320  C  CG  . MET   A 1 44  ? 36.32203 -24.64184 -17.42966 1.000 36.79889 ?  578  MET   A CG  1 
ATOM   321  S  SD  . MET   A 1 44  ? 36.53143 -26.12710 -18.42790 1.000 34.92140 ?  578  MET   A SD  1 
ATOM   322  C  CE  . MET   A 1 44  ? 34.85371 -26.74805 -18.48004 1.000 28.49160 ?  578  MET   A CE  1 
ATOM   323  N  N   . PHE   A 1 45  ? 33.48034 -24.68776 -13.88388 1.000 36.97100 ?  579  PHE   A N   1 
ATOM   324  C  CA  . PHE   A 1 45  ? 32.28831 -24.43926 -13.07943 1.000 34.11217 ?  579  PHE   A CA  1 
ATOM   325  C  C   . PHE   A 1 45  ? 32.59260 -23.47594 -11.94136 1.000 38.33285 ?  579  PHE   A C   1 
ATOM   326  O  O   . PHE   A 1 45  ? 31.84906 -22.51790 -11.70090 1.000 40.35920 ?  579  PHE   A O   1 
ATOM   327  C  CB  . PHE   A 1 45  ? 31.75524 -25.75615 -12.51077 1.000 34.09133 ?  579  PHE   A CB  1 
ATOM   328  C  CG  . PHE   A 1 45  ? 30.92428 -26.55486 -13.47254 1.000 39.65608 ?  579  PHE   A CG  1 
ATOM   329  C  CD1 . PHE   A 1 45  ? 29.62104 -26.18434 -13.75777 1.000 35.59462 ?  579  PHE   A CD1 1 
ATOM   330  C  CD2 . PHE   A 1 45  ? 31.43863 -27.69401 -14.07103 1.000 36.46259 ?  579  PHE   A CD2 1 
ATOM   331  C  CE1 . PHE   A 1 45  ? 28.85272 -26.92741 -14.63404 1.000 36.52708 ?  579  PHE   A CE1 1 
ATOM   332  C  CE2 . PHE   A 1 45  ? 30.67574 -28.44042 -14.94810 1.000 29.07865 ?  579  PHE   A CE2 1 
ATOM   333  C  CZ  . PHE   A 1 45  ? 29.38181 -28.05693 -15.22983 1.000 32.30700 ?  579  PHE   A CZ  1 
ATOM   334  N  N   . THR   A 1 46  ? 33.69844 -23.71936 -11.23489 1.000 37.49438 ?  580  THR   A N   1 
ATOM   335  C  CA  . THR   A 1 46  ? 34.01611 -22.96050 -10.03036 1.000 34.11995 ?  580  THR   A CA  1 
ATOM   336  C  C   . THR   A 1 46  ? 34.24247 -21.48788 -10.34635 1.000 39.67010 ?  580  THR   A C   1 
ATOM   337  O  O   . THR   A 1 46  ? 33.57664 -20.60829 -9.78872  1.000 43.73864 ?  580  THR   A O   1 
ATOM   338  C  CB  . THR   A 1 46  ? 35.24962 -23.55933 -9.35292  1.000 35.04342 ?  580  THR   A CB  1 
ATOM   339  O  OG1 . THR   A 1 46  ? 34.94623 -24.87836 -8.88448  1.000 36.02792 ?  580  THR   A OG1 1 
ATOM   340  C  CG2 . THR   A 1 46  ? 35.68555 -22.69572 -8.18098  1.000 33.94397 ?  580  THR   A CG2 1 
ATOM   341  N  N   . ASP   A 1 47  ? 35.18689 -21.19882 -11.24072 1.000 43.49021 ?  581  ASP   A N   1 
ATOM   342  C  CA  . ASP   A 1 47  ? 35.53619 -19.81548 -11.53069 1.000 41.81844 ?  581  ASP   A CA  1 
ATOM   343  C  C   . ASP   A 1 47  ? 34.51218 -19.11140 -12.41074 1.000 40.12323 ?  581  ASP   A C   1 
ATOM   344  O  O   . ASP   A 1 47  ? 34.64779 -17.90538 -12.64060 1.000 39.50354 ?  581  ASP   A O   1 
ATOM   345  C  CB  . ASP   A 1 47  ? 36.92192 -19.74626 -12.17224 1.000 37.83011 ?  581  ASP   A CB  1 
ATOM   346  C  CG  . ASP   A 1 47  ? 38.03527 -19.77050 -11.14304 1.000 39.86423 ?  581  ASP   A CG  1 
ATOM   347  O  OD1 . ASP   A 1 47  ? 37.72523 -19.86983 -9.93612  1.000 40.46934 ?  581  ASP   A OD1 1 
ATOM   348  O  OD2 . ASP   A 1 47  ? 39.21619 -19.68829 -11.53713 1.000 51.51799 ?  581  ASP   A OD2 1 
ATOM   349  N  N   . LEU   A 1 48  ? 33.50302 -19.82343 -12.91308 1.000 43.40013 ?  582  LEU   A N   1 
ATOM   350  C  CA  . LEU   A 1 48  ? 32.31425 -19.18689 -13.46104 1.000 36.47179 ?  582  LEU   A CA  1 
ATOM   351  C  C   . LEU   A 1 48  ? 31.24047 -18.97788 -12.40436 1.000 44.39658 ?  582  LEU   A C   1 
ATOM   352  O  O   . LEU   A 1 48  ? 30.07667 -18.74388 -12.75192 1.000 49.11391 ?  582  LEU   A O   1 
ATOM   353  C  CB  . LEU   A 1 48  ? 31.75198 -19.99747 -14.62946 1.000 37.27913 ?  582  LEU   A CB  1 
ATOM   354  C  CG  . LEU   A 1 48  ? 32.48183 -19.85298 -15.96420 1.000 36.63340 ?  582  LEU   A CG  1 
ATOM   355  C  CD1 . LEU   A 1 48  ? 32.11283 -20.99340 -16.89884 1.000 28.32662 ?  582  LEU   A CD1 1 
ATOM   356  C  CD2 . LEU   A 1 48  ? 32.17119 -18.50526 -16.59459 1.000 37.01015 ?  582  LEU   A CD2 1 
ATOM   357  N  N   . ASN   A 1 49  ? 31.61078 -19.07250 -11.12402 1.000 47.60203 ?  583  ASN   A N   1 
ATOM   358  C  CA  . ASN   A 1 49  ? 30.71365 -18.82303 -9.99549  1.000 38.89192 ?  583  ASN   A CA  1 
ATOM   359  C  C   . ASN   A 1 49  ? 29.46175 -19.69459 -10.05468 1.000 40.31073 ?  583  ASN   A C   1 
ATOM   360  O  O   . ASN   A 1 49  ? 28.40668 -19.31832 -9.53819  1.000 42.27075 ?  583  ASN   A O   1 
ATOM   361  C  CB  . ASN   A 1 49  ? 30.33710 -17.34117 -9.91115  1.000 40.80592 ?  583  ASN   A CB  1 
ATOM   362  C  CG  . ASN   A 1 49  ? 31.53925 -16.42569 -10.06837 1.000 48.72951 ?  583  ASN   A CG  1 
ATOM   363  O  OD1 . ASN   A 1 49  ? 31.68520 -15.74355 -11.08194 1.000 53.31741 ?  583  ASN   A OD1 1 
ATOM   364  N  ND2 . ASN   A 1 49  ? 32.40950 -16.41153 -9.06473  1.000 49.02448 ?  583  ASN   A ND2 1 
ATOM   365  N  N   . LEU   A 1 50  ? 29.57307 -20.87127 -10.67543 1.000 40.46801 ?  584  LEU   A N   1 
ATOM   366  C  CA  . LEU   A 1 50  ? 28.42117 -21.75506 -10.81533 1.000 41.15836 ?  584  LEU   A CA  1 
ATOM   367  C  C   . LEU   A 1 50  ? 28.21307 -22.60526 -9.56855  1.000 37.69696 ?  584  LEU   A C   1 
ATOM   368  O  O   . LEU   A 1 50  ? 27.07349 -22.79744 -9.12950  1.000 42.04189 ?  584  LEU   A O   1 
ATOM   369  C  CB  . LEU   A 1 50  ? 28.59322 -22.64582 -12.04569 1.000 41.45052 ?  584  LEU   A CB  1 
ATOM   370  C  CG  . LEU   A 1 50  ? 28.47768 -21.91690 -13.38505 1.000 44.96203 ?  584  LEU   A CG  1 
ATOM   371  C  CD1 . LEU   A 1 50  ? 28.49080 -22.89542 -14.55057 1.000 42.32103 ?  584  LEU   A CD1 1 
ATOM   372  C  CD2 . LEU   A 1 50  ? 27.22719 -21.05269 -13.41282 1.000 41.90791 ?  584  LEU   A CD2 1 
ATOM   373  N  N   . VAL   A 1 51  ? 29.30006 -23.12531 -8.99124  1.000 36.81267 ?  585  VAL   A N   1 
ATOM   374  C  CA  . VAL   A 1 51  ? 29.19899 -23.87529 -7.74240  1.000 33.98986 ?  585  VAL   A CA  1 
ATOM   375  C  C   . VAL   A 1 51  ? 28.63203 -22.99494 -6.63758  1.000 35.12808 ?  585  VAL   A C   1 
ATOM   376  O  O   . VAL   A 1 51  ? 27.91506 -23.47569 -5.75096  1.000 39.97273 ?  585  VAL   A O   1 
ATOM   377  C  CB  . VAL   A 1 51  ? 30.57770 -24.45090 -7.35789  1.000 31.13966 ?  585  VAL   A CB  1 
ATOM   378  C  CG1 . VAL   A 1 51  ? 30.49377 -25.24386 -6.05957  1.000 32.07248 ?  585  VAL   A CG1 1 
ATOM   379  C  CG2 . VAL   A 1 51  ? 31.12792 -25.31306 -8.48480  1.000 31.65238 ?  585  VAL   A CG2 1 
ATOM   380  N  N   . GLN   A 1 52  ? 28.92321 -21.69407 -6.68138  1.000 45.19606 ?  586  GLN   A N   1 
ATOM   381  C  CA  . GLN   A 1 52  ? 28.42824 -20.77706 -5.65999  1.000 41.21760 ?  586  GLN   A CA  1 
ATOM   382  C  C   . GLN   A 1 52  ? 26.93911 -20.50245 -5.83320  1.000 40.49212 ?  586  GLN   A C   1 
ATOM   383  O  O   . GLN   A 1 52  ? 26.13116 -20.79181 -4.94287  1.000 44.84238 ?  586  GLN   A O   1 
ATOM   384  C  CB  . GLN   A 1 52  ? 29.22160 -19.46917 -5.71060  1.000 39.05536 ?  586  GLN   A CB  1 
ATOM   385  C  CG  . GLN   A 1 52  ? 29.02808 -18.56330 -4.50219  1.000 47.13153 ?  586  GLN   A CG  1 
ATOM   386  C  CD  . GLN   A 1 52  ? 29.10148 -19.30895 -3.18378  1.000 42.14531 ?  586  GLN   A CD  1 
ATOM   387  O  OE1 . GLN   A 1 52  ? 30.00362 -20.11773 -2.96077  1.000 44.67905 ?  586  GLN   A OE1 1 
ATOM   388  N  NE2 . GLN   A 1 52  ? 28.14866 -19.03809 -2.29974  1.000 40.52078 ?  586  GLN   A NE2 1 
ATOM   389  N  N   . ASN   A 1 53  ? 26.55920 -19.93765 -6.98122  1.000 38.79394 ?  587  ASN   A N   1 
ATOM   390  C  CA  . ASN   A 1 53  ? 25.21740 -19.39178 -7.15188  1.000 43.70574 ?  587  ASN   A CA  1 
ATOM   391  C  C   . ASN   A 1 53  ? 24.13312 -20.46040 -7.18728  1.000 42.22708 ?  587  ASN   A C   1 
ATOM   392  O  O   . ASN   A 1 53  ? 22.96743 -20.14567 -6.92577  1.000 48.89446 ?  587  ASN   A O   1 
ATOM   393  C  CB  . ASN   A 1 53  ? 25.15903 -18.55632 -8.43012  1.000 42.28129 ?  587  ASN   A CB  1 
ATOM   394  C  CG  . ASN   A 1 53  ? 26.13955 -17.40281 -8.41219  1.000 48.29277 ?  587  ASN   A CG  1 
ATOM   395  O  OD1 . ASN   A 1 53  ? 26.86237 -17.20562 -7.43544  1.000 56.77412 ?  587  ASN   A OD1 1 
ATOM   396  N  ND2 . ASN   A 1 53  ? 26.17165 -16.63376 -9.49382  1.000 46.21583 ?  587  ASN   A ND2 1 
ATOM   397  N  N   . PHE   A 1 54  ? 24.47637 -21.70807 -7.50705  1.000 38.67682 ?  588  PHE   A N   1 
ATOM   398  C  CA  . PHE   A 1 54  ? 23.47887 -22.76615 -7.61684  1.000 36.78669 ?  588  PHE   A CA  1 
ATOM   399  C  C   . PHE   A 1 54  ? 23.71509 -23.88927 -6.61398  1.000 38.52278 ?  588  PHE   A C   1 
ATOM   400  O  O   . PHE   A 1 54  ? 23.14771 -24.97576 -6.76219  1.000 44.66955 ?  588  PHE   A O   1 
ATOM   401  C  CB  . PHE   A 1 54  ? 23.43203 -23.30248 -9.04802  1.000 33.23277 ?  588  PHE   A CB  1 
ATOM   402  C  CG  . PHE   A 1 54  ? 23.15255 -22.23962 -10.07207 1.000 35.96548 ?  588  PHE   A CG  1 
ATOM   403  C  CD1 . PHE   A 1 54  ? 21.87106 -21.73880 -10.23344 1.000 36.19155 ?  588  PHE   A CD1 1 
ATOM   404  C  CD2 . PHE   A 1 54  ? 24.17186 -21.72209 -10.85327 1.000 38.01659 ?  588  PHE   A CD2 1 
ATOM   405  C  CE1 . PHE   A 1 54  ? 21.60743 -20.75357 -11.16330 1.000 38.04586 ?  588  PHE   A CE1 1 
ATOM   406  C  CE2 . PHE   A 1 54  ? 23.91442 -20.73468 -11.78653 1.000 42.47511 ?  588  PHE   A CE2 1 
ATOM   407  C  CZ  . PHE   A 1 54  ? 22.62964 -20.25028 -11.94121 1.000 42.63576 ?  588  PHE   A CZ  1 
ATOM   408  N  N   . GLN   A 1 55  ? 24.55002 -23.64311 -5.60131  1.000 38.29348 ?  589  GLN   A N   1 
ATOM   409  C  CA  . GLN   A 1 55  ? 24.65263 -24.50038 -4.41822  1.000 38.94346 ?  589  GLN   A CA  1 
ATOM   410  C  C   . GLN   A 1 55  ? 24.98394 -25.94656 -4.78995  1.000 41.28032 ?  589  GLN   A C   1 
ATOM   411  O  O   . GLN   A 1 55  ? 24.32211 -26.89268 -4.35837  1.000 43.48452 ?  589  GLN   A O   1 
ATOM   412  C  CB  . GLN   A 1 55  ? 23.36465 -24.42338 -3.59325  1.000 37.61143 ?  589  GLN   A CB  1 
ATOM   413  C  CG  . GLN   A 1 55  ? 23.03348 -23.01410 -3.11567  1.000 41.30102 ?  589  GLN   A CG  1 
ATOM   414  C  CD  . GLN   A 1 55  ? 21.74981 -22.47414 -3.72045  1.000 49.91671 ?  589  GLN   A CD  1 
ATOM   415  O  OE1 . GLN   A 1 55  ? 20.66153 -22.98740 -3.45912  1.000 56.05962 ?  589  GLN   A OE1 1 
ATOM   416  N  NE2 . GLN   A 1 55  ? 21.87321 -21.43406 -4.53828  1.000 49.26281 ?  589  GLN   A NE2 1 
ATOM   417  N  N   . MET   A 1 56  ? 26.02846 -26.11357 -5.59616  1.000 35.24528 ?  590  MET   A N   1 
ATOM   418  C  CA  . MET   A 1 56  ? 26.42728 -27.43637 -6.05631  1.000 38.87948 ?  590  MET   A CA  1 
ATOM   419  C  C   . MET   A 1 56  ? 27.31615 -28.11153 -5.02216  1.000 38.33497 ?  590  MET   A C   1 
ATOM   420  O  O   . MET   A 1 56  ? 28.29307 -27.52233 -4.55017  1.000 41.75943 ?  590  MET   A O   1 
ATOM   421  C  CB  . MET   A 1 56  ? 27.16155 -27.33786 -7.39080  1.000 34.27318 ?  590  MET   A CB  1 
ATOM   422  C  CG  . MET   A 1 56  ? 26.36112 -26.67300 -8.48665  1.000 34.50117 ?  590  MET   A CG  1 
ATOM   423  S  SD  . MET   A 1 56  ? 27.18360 -26.80420 -10.08227 1.000 34.59342 ?  590  MET   A SD  1 
ATOM   424  C  CE  . MET   A 1 56  ? 26.41168 -25.45114 -10.96038 1.000 28.26491 ?  590  MET   A CE  1 
ATOM   425  N  N   . LYS   A 1 57  ? 26.97506 -29.34822 -4.66930  1.000 33.66975 ?  591  LYS   A N   1 
ATOM   426  C  CA  . LYS   A 1 57  ? 27.79951 -30.12850 -3.75796  1.000 39.04246 ?  591  LYS   A CA  1 
ATOM   427  C  C   . LYS   A 1 57  ? 28.96200 -30.74900 -4.52360  1.000 41.14952 ?  591  LYS   A C   1 
ATOM   428  O  O   . LYS   A 1 57  ? 28.79749 -31.22199 -5.65162  1.000 43.90658 ?  591  LYS   A O   1 
ATOM   429  C  CB  . LYS   A 1 57  ? 26.96132 -31.20982 -3.07465  1.000 49.18033 ?  591  LYS   A CB  1 
ATOM   430  C  CG  . LYS   A 1 57  ? 26.07073 -30.69166 -1.94990  1.000 51.75520 ?  591  LYS   A CG  1 
ATOM   431  C  CD  . LYS   A 1 57  ? 25.52948 -31.82397 -1.08705  1.000 49.84156 ?  591  LYS   A CD  1 
ATOM   432  C  CE  . LYS   A 1 57  ? 24.23464 -32.38116 -1.66099  1.000 60.99800 ?  591  LYS   A CE  1 
ATOM   433  N  NZ  . LYS   A 1 57  ? 23.24234 -31.30386 -1.93603  1.000 50.09648 ?  591  LYS   A NZ  1 
ATOM   434  N  N   . HIS   A 1 58  ? 30.14357 -30.74107 -3.89871  1.000 43.14820 ?  592  HIS   A N   1 
ATOM   435  C  CA  . HIS   A 1 58  ? 31.37478 -31.07795 -4.61079  1.000 41.40054 ?  592  HIS   A CA  1 
ATOM   436  C  C   . HIS   A 1 58  ? 31.33645 -32.49038 -5.18494  1.000 43.63673 ?  592  HIS   A C   1 
ATOM   437  O  O   . HIS   A 1 58  ? 31.80904 -32.72551 -6.30397  1.000 45.15963 ?  592  HIS   A O   1 
ATOM   438  C  CB  . HIS   A 1 58  ? 32.57342 -30.91316 -3.67592  1.000 44.45720 ?  592  HIS   A CB  1 
ATOM   439  C  CG  . HIS   A 1 58  ? 33.89173 -30.88831 -4.38323  1.000 51.92842 ?  592  HIS   A CG  1 
ATOM   440  N  ND1 . HIS   A 1 58  ? 34.40820 -29.74533 -4.95443  1.000 54.13034 ?  592  HIS   A ND1 1 
ATOM   441  C  CD2 . HIS   A 1 58  ? 34.79924 -31.86678 -4.61201  1.000 45.99432 ?  592  HIS   A CD2 1 
ATOM   442  C  CE1 . HIS   A 1 58  ? 35.57668 -30.02119 -5.50550  1.000 43.78085 ?  592  HIS   A CE1 1 
ATOM   443  N  NE2 . HIS   A 1 58  ? 35.83723 -31.30147 -5.31156  1.000 36.62771 ?  592  HIS   A NE2 1 
ATOM   444  N  N   . GLU   A 1 59  ? 30.77816 -33.44323 -4.43910  1.000 45.71485 ?  593  GLU   A N   1 
ATOM   445  C  CA  . GLU   A 1 59  ? 30.76845 -34.82872 -4.89095  1.000 45.53519 ?  593  GLU   A CA  1 
ATOM   446  C  C   . GLU   A 1 59  ? 29.71427 -35.09979 -5.95651  1.000 40.69748 ?  593  GLU   A C   1 
ATOM   447  O  O   . GLU   A 1 59  ? 29.82443 -36.10104 -6.67227  1.000 41.33773 ?  593  GLU   A O   1 
ATOM   448  C  CB  . GLU   A 1 59  ? 30.56212 -35.77535 -3.70521  1.000 46.61214 ?  593  GLU   A CB  1 
ATOM   449  C  CG  . GLU   A 1 59  ? 29.20870 -35.66352 -3.02018  1.000 47.31931 ?  593  GLU   A CG  1 
ATOM   450  C  CD  . GLU   A 1 59  ? 29.10731 -34.45719 -2.10562  1.000 54.20913 ?  593  GLU   A CD  1 
ATOM   451  O  OE1 . GLU   A 1 59  ? 30.15400 -33.84431 -1.80424  1.000 53.53561 ?  593  GLU   A OE1 1 
ATOM   452  O  OE2 . GLU   A 1 59  ? 27.98003 -34.12467 -1.68423  1.000 58.27168 ?  593  GLU   A OE2 1 
ATOM   453  N  N   . VAL   A 1 60  ? 28.69686 -34.24515 -6.07716  1.000 41.27794 ?  594  VAL   A N   1 
ATOM   454  C  CA  . VAL   A 1 60  ? 27.75817 -34.37083 -7.18914  1.000 38.78801 ?  594  VAL   A CA  1 
ATOM   455  C  C   . VAL   A 1 60  ? 28.41800 -33.92810 -8.48925  1.000 39.82132 ?  594  VAL   A C   1 
ATOM   456  O  O   . VAL   A 1 60  ? 28.32923 -34.61325 -9.51470  1.000 37.78697 ?  594  VAL   A O   1 
ATOM   457  C  CB  . VAL   A 1 60  ? 26.47313 -33.57244 -6.90699  1.000 37.45494 ?  594  VAL   A CB  1 
ATOM   458  C  CG1 . VAL   A 1 60  ? 25.33655 -34.08281 -7.77455  1.000 38.45271 ?  594  VAL   A CG1 1 
ATOM   459  C  CG2 . VAL   A 1 60  ? 26.10115 -33.68303 -5.44208  1.000 41.94791 ?  594  VAL   A CG2 1 
ATOM   460  N  N   . LEU   A 1 61  ? 29.09596 -32.77714 -8.46149  1.000 39.71205 ?  595  LEU   A N   1 
ATOM   461  C  CA  . LEU   A 1 61  ? 29.79483 -32.29107 -9.64676  1.000 35.21127 ?  595  LEU   A CA  1 
ATOM   462  C  C   . LEU   A 1 61  ? 30.86327 -33.27638 -10.10202 1.000 36.25423 ?  595  LEU   A C   1 
ATOM   463  O  O   . LEU   A 1 61  ? 30.98902 -33.55788 -11.29988 1.000 40.79654 ?  595  LEU   A O   1 
ATOM   464  C  CB  . LEU   A 1 61  ? 30.41342 -30.92495 -9.35953  1.000 33.31597 ?  595  LEU   A CB  1 
ATOM   465  C  CG  . LEU   A 1 61  ? 30.89373 -30.12345 -10.56940 1.000 31.61807 ?  595  LEU   A CG  1 
ATOM   466  C  CD1 . LEU   A 1 61  ? 29.90940 -30.23075 -11.72707 1.000 37.30210 ?  595  LEU   A CD1 1 
ATOM   467  C  CD2 . LEU   A 1 61  ? 31.12627 -28.67256 -10.18559 1.000 29.80679 ?  595  LEU   A CD2 1 
ATOM   468  N  N   . CYS   A 1 62  ? 31.64230 -33.81037 -9.15907  1.000 38.10121 ?  596  CYS   A N   1 
ATOM   469  C  CA  . CYS   A 1 62  ? 32.63721 -34.82192 -9.50024  1.000 39.26667 ?  596  CYS   A CA  1 
ATOM   470  C  C   . CYS   A 1 62  ? 31.98225 -36.02981 -10.15645 1.000 35.20672 ?  596  CYS   A C   1 
ATOM   471  O  O   . CYS   A 1 62  ? 32.43632 -36.50724 -11.20284 1.000 35.24713 ?  596  CYS   A O   1 
ATOM   472  C  CB  . CYS   A 1 62  ? 33.40428 -35.24499 -8.24796  1.000 38.29281 ?  596  CYS   A CB  1 
ATOM   473  S  SG  . CYS   A 1 62  ? 34.55828 -34.01031 -7.61927  1.000 39.16706 ?  596  CYS   A SG  1 
ATOM   474  N  N   . ARG   A 1 63  ? 30.90325 -36.53440 -9.55326  1.000 36.97005 ?  597  ARG   A N   1 
ATOM   475  C  CA  . ARG   A 1 63  ? 30.20701 -37.68588 -10.11557 1.000 37.52678 ?  597  ARG   A CA  1 
ATOM   476  C  C   . ARG   A 1 63  ? 29.52115 -37.34030 -11.43043 1.000 40.43513 ?  597  ARG   A C   1 
ATOM   477  O  O   . ARG   A 1 63  ? 29.44358 -38.18754 -12.32777 1.000 33.79691 ?  597  ARG   A O   1 
ATOM   478  C  CB  . ARG   A 1 63  ? 29.19150 -38.22357 -9.10740  1.000 32.20079 ?  597  ARG   A CB  1 
ATOM   479  C  CG  . ARG   A 1 63  ? 28.71619 -39.64083 -9.38038  1.000 35.51905 ?  597  ARG   A CG  1 
ATOM   480  C  CD  . ARG   A 1 63  ? 27.63664 -40.05530 -8.39058  1.000 43.39245 ?  597  ARG   A CD  1 
ATOM   481  N  NE  . ARG   A 1 63  ? 28.20391 -40.65848 -7.18996  1.000 46.03704 ?  597  ARG   A NE  1 
ATOM   482  C  CZ  . ARG   A 1 63  ? 28.49992 -39.99128 -6.08270  1.000 43.87764 ?  597  ARG   A CZ  1 
ATOM   483  N  NH1 . ARG   A 1 63  ? 28.29316 -38.68797 -5.98392  1.000 37.13101 ?  597  ARG   A NH1 1 
ATOM   484  N  NH2 . ARG   A 1 63  ? 29.01678 -40.64821 -5.04845  1.000 47.23572 ?  597  ARG   A NH2 1 
ATOM   485  N  N   . TRP   A 1 64  ? 29.02348 -36.10840 -11.56701 1.000 35.75765 ?  598  TRP   A N   1 
ATOM   486  C  CA  . TRP   A 1 64  ? 28.39024 -35.70892 -12.81942 1.000 30.22915 ?  598  TRP   A CA  1 
ATOM   487  C  C   . TRP   A 1 64  ? 29.40686 -35.62022 -13.94997 1.000 35.60249 ?  598  TRP   A C   1 
ATOM   488  O  O   . TRP   A 1 64  ? 29.12803 -36.04642 -15.07651 1.000 36.48240 ?  598  TRP   A O   1 
ATOM   489  C  CB  . TRP   A 1 64  ? 27.67099 -34.37331 -12.64881 1.000 35.61134 ?  598  TRP   A CB  1 
ATOM   490  C  CG  . TRP   A 1 64  ? 27.02484 -33.89611 -13.91090 1.000 40.19198 ?  598  TRP   A CG  1 
ATOM   491  C  CD1 . TRP   A 1 64  ? 25.78377 -34.22540 -14.37245 1.000 33.40021 ?  598  TRP   A CD1 1 
ATOM   492  C  CD2 . TRP   A 1 64  ? 27.59612 -33.01631 -14.88659 1.000 39.06767 ?  598  TRP   A CD2 1 
ATOM   493  N  NE1 . TRP   A 1 64  ? 25.54340 -33.59750 -15.57099 1.000 36.59378 ?  598  TRP   A NE1 1 
ATOM   494  C  CE2 . TRP   A 1 64  ? 26.64097 -32.84978 -15.90909 1.000 37.57425 ?  598  TRP   A CE2 1 
ATOM   495  C  CE3 . TRP   A 1 64  ? 28.82107 -32.35033 -14.99229 1.000 35.69339 ?  598  TRP   A CE3 1 
ATOM   496  C  CZ2 . TRP   A 1 64  ? 26.87251 -32.04410 -17.02312 1.000 35.05661 ?  598  TRP   A CZ2 1 
ATOM   497  C  CZ3 . TRP   A 1 64  ? 29.04935 -31.55132 -16.09868 1.000 35.45107 ?  598  TRP   A CZ3 1 
ATOM   498  C  CH2 . TRP   A 1 64  ? 28.08001 -31.40504 -17.09920 1.000 38.02740 ?  598  TRP   A CH2 1 
ATOM   499  N  N   . ILE   A 1 65  ? 30.58613 -35.06095 -13.67185 1.000 36.52117 ?  599  ILE   A N   1 
ATOM   500  C  CA  . ILE   A 1 65  ? 31.63281 -34.98052 -14.68790 1.000 32.56166 ?  599  ILE   A CA  1 
ATOM   501  C  C   . ILE   A 1 65  ? 32.05535 -36.37676 -15.12248 1.000 34.04101 ?  599  ILE   A C   1 
ATOM   502  O  O   . ILE   A 1 65  ? 32.13905 -36.67883 -16.31921 1.000 36.61114 ?  599  ILE   A O   1 
ATOM   503  C  CB  . ILE   A 1 65  ? 32.83173 -34.17449 -14.15895 1.000 31.39613 ?  599  ILE   A CB  1 
ATOM   504  C  CG1 . ILE   A 1 65  ? 32.45479 -32.70333 -13.99555 1.000 30.90754 ?  599  ILE   A CG1 1 
ATOM   505  C  CG2 . ILE   A 1 65  ? 34.02971 -34.33354 -15.08333 1.000 29.44233 ?  599  ILE   A CG2 1 
ATOM   506  C  CD1 . ILE   A 1 65  ? 33.51686 -31.88535 -13.31736 1.000 29.89209 ?  599  ILE   A CD1 1 
ATOM   507  N  N   . LEU   A 1 66  ? 32.32099 -37.25184 -14.15064 1.000 35.78975 ?  600  LEU   A N   1 
ATOM   508  C  CA  . LEU   A 1 66  ? 32.80558 -38.58947 -14.46798 1.000 37.00902 ?  600  LEU   A CA  1 
ATOM   509  C  C   . LEU   A 1 66  ? 31.76664 -39.40075 -15.23042 1.000 38.02395 ?  600  LEU   A C   1 
ATOM   510  O  O   . LEU   A 1 66  ? 32.12622 -40.28362 -16.01783 1.000 34.36164 ?  600  LEU   A O   1 
ATOM   511  C  CB  . LEU   A 1 66  ? 33.21388 -39.31019 -13.18473 1.000 38.33351 ?  600  LEU   A CB  1 
ATOM   512  C  CG  . LEU   A 1 66  ? 34.61778 -38.95409 -12.69476 1.000 42.44842 ?  600  LEU   A CG  1 
ATOM   513  C  CD1 . LEU   A 1 66  ? 34.88002 -39.51838 -11.30628 1.000 47.67018 ?  600  LEU   A CD1 1 
ATOM   514  C  CD2 . LEU   A 1 66  ? 35.65638 -39.43974 -13.68955 1.000 40.79293 ?  600  LEU   A CD2 1 
ATOM   515  N  N   . SER   A 1 67  ? 30.47902 -39.12140 -15.01366 1.000 39.54196 ?  601  SER   A N   1 
ATOM   516  C  CA  . SER   A 1 67  ? 29.44327 -39.79199 -15.79195 1.000 36.38012 ?  601  SER   A CA  1 
ATOM   517  C  C   . SER   A 1 67  ? 29.38113 -39.23873 -17.20902 1.000 35.66346 ?  601  SER   A C   1 
ATOM   518  O  O   . SER   A 1 67  ? 29.16469 -39.99165 -18.16597 1.000 32.00968 ?  601  SER   A O   1 
ATOM   519  C  CB  . SER   A 1 67  ? 28.08908 -39.65227 -15.09906 1.000 30.71206 ?  601  SER   A CB  1 
ATOM   520  O  OG  . SER   A 1 67  ? 28.21145 -39.83662 -13.69996 1.000 38.21703 ?  601  SER   A OG  1 
ATOM   521  N  N   . VAL   A 1 68  ? 29.56334 -37.92416 -17.36182 1.000 34.09281 ?  602  VAL   A N   1 
ATOM   522  C  CA  . VAL   A 1 68  ? 29.63332 -37.33446 -18.69597 1.000 34.93243 ?  602  VAL   A CA  1 
ATOM   523  C  C   . VAL   A 1 68  ? 30.81232 -37.91495 -19.46468 1.000 38.73865 ?  602  VAL   A C   1 
ATOM   524  O  O   . VAL   A 1 68  ? 30.68723 -38.28600 -20.63786 1.000 42.63421 ?  602  VAL   A O   1 
ATOM   525  C  CB  . VAL   A 1 68  ? 29.71516 -35.79901 -18.59943 1.000 34.23145 ?  602  VAL   A CB  1 
ATOM   526  C  CG1 . VAL   A 1 68  ? 30.15989 -35.19884 -19.92793 1.000 28.06077 ?  602  VAL   A CG1 1 
ATOM   527  C  CG2 . VAL   A 1 68  ? 28.37393 -35.22318 -18.17362 1.000 35.53269 ?  602  VAL   A CG2 1 
ATOM   528  N  N   . LYS   A 1 69  ? 31.97129 -38.01804 -18.80886 1.000 32.87386 ?  603  LYS   A N   1 
ATOM   529  C  CA  . LYS   A 1 69  ? 33.12956 -38.64672 -19.43521 1.000 33.92724 ?  603  LYS   A CA  1 
ATOM   530  C  C   . LYS   A 1 69  ? 32.85392 -40.10682 -19.76944 1.000 35.44302 ?  603  LYS   A C   1 
ATOM   531  O  O   . LYS   A 1 69  ? 33.24828 -40.59233 -20.83657 1.000 42.87642 ?  603  LYS   A O   1 
ATOM   532  C  CB  . LYS   A 1 69  ? 34.34490 -38.53372 -18.51699 1.000 38.29594 ?  603  LYS   A CB  1 
ATOM   533  C  CG  . LYS   A 1 69  ? 35.67181 -38.79419 -19.20726 1.000 38.46914 ?  603  LYS   A CG  1 
ATOM   534  C  CD  . LYS   A 1 69  ? 36.84381 -38.41810 -18.31624 1.000 40.00605 ?  603  LYS   A CD  1 
ATOM   535  C  CE  . LYS   A 1 69  ? 37.17771 -39.53750 -17.34546 1.000 39.18185 ?  603  LYS   A CE  1 
ATOM   536  N  NZ  . LYS   A 1 69  ? 37.96726 -40.61419 -18.00435 1.000 42.82122 ?  603  LYS   A NZ  1 
ATOM   537  N  N   . LYS   A 1 70  ? 32.17922 -40.82246 -18.86597 1.000 37.65276 ?  604  LYS   A N   1 
ATOM   538  C  CA  . LYS   A 1 70  ? 31.89081 -42.23508 -19.09498 1.000 42.80545 ?  604  LYS   A CA  1 
ATOM   539  C  C   . LYS   A 1 70  ? 31.04954 -42.43654 -20.34896 1.000 40.62980 ?  604  LYS   A C   1 
ATOM   540  O  O   . LYS   A 1 70  ? 31.23821 -43.41506 -21.08167 1.000 43.66715 ?  604  LYS   A O   1 
ATOM   541  C  CB  . LYS   A 1 70  ? 31.17648 -42.82613 -17.87975 1.000 39.36499 ?  604  LYS   A CB  1 
ATOM   542  C  CG  . LYS   A 1 70  ? 31.69875 -44.18048 -17.43092 1.000 43.62693 ?  604  LYS   A CG  1 
ATOM   543  C  CD  . LYS   A 1 70  ? 32.97831 -44.04873 -16.62428 1.000 62.44160 ?  604  LYS   A CD  1 
ATOM   544  C  CE  . LYS   A 1 70  ? 33.60781 -45.40796 -16.38219 1.000 66.26805 ?  604  LYS   A CE  1 
ATOM   545  N  NZ  . LYS   A 1 70  ? 35.09061 -45.33758 -16.43791 1.000 55.76186 ?  604  LYS   A NZ  1 
ATOM   546  N  N   . ASN   A 1 71  ? 30.11830 -41.52352 -20.61469 1.000 38.85100 ?  605  ASN   A N   1 
ATOM   547  C  CA  . ASN   A 1 71  ? 29.18357 -41.67529 -21.72047 1.000 36.54860 ?  605  ASN   A CA  1 
ATOM   548  C  C   . ASN   A 1 71  ? 29.72342 -41.13175 -23.03851 1.000 39.02660 ?  605  ASN   A C   1 
ATOM   549  O  O   . ASN   A 1 71  ? 28.96045 -41.00567 -24.00145 1.000 43.40743 ?  605  ASN   A O   1 
ATOM   550  C  CB  . ASN   A 1 71  ? 27.85073 -41.01176 -21.37539 1.000 37.78036 ?  605  ASN   A CB  1 
ATOM   551  C  CG  . ASN   A 1 71  ? 26.85656 -41.99098 -20.78516 1.000 43.61579 ?  605  ASN   A CG  1 
ATOM   552  O  OD1 . ASN   A 1 71  ? 26.05909 -42.59420 -21.50267 1.000 47.33580 ?  605  ASN   A OD1 1 
ATOM   553  N  ND2 . ASN   A 1 71  ? 26.91316 -42.16904 -19.47025 1.000 37.40151 ?  605  ASN   A ND2 1 
ATOM   554  N  N   . TYR   A 1 72  ? 31.00715 -40.79671 -23.09895 1.000 39.30288 ?  606  TYR   A N   1 
ATOM   555  C  CA  . TYR   A 1 72  ? 31.71595 -40.65753 -24.36077 1.000 33.86281 ?  606  TYR   A CA  1 
ATOM   556  C  C   . TYR   A 1 72  ? 32.52286 -41.92397 -24.61401 1.000 41.47902 ?  606  TYR   A C   1 
ATOM   557  O  O   . TYR   A 1 72  ? 32.88001 -42.65681 -23.68833 1.000 42.53888 ?  606  TYR   A O   1 
ATOM   558  C  CB  . TYR   A 1 72  ? 32.62823 -39.42857 -24.36256 1.000 35.73388 ?  606  TYR   A CB  1 
ATOM   559  C  CG  . TYR   A 1 72  ? 31.87600 -38.12565 -24.49129 1.000 35.08594 ?  606  TYR   A CG  1 
ATOM   560  C  CD1 . TYR   A 1 72  ? 31.54141 -37.61499 -25.73736 1.000 30.74258 ?  606  TYR   A CD1 1 
ATOM   561  C  CD2 . TYR   A 1 72  ? 31.49468 -37.40932 -23.36797 1.000 35.50681 ?  606  TYR   A CD2 1 
ATOM   562  C  CE1 . TYR   A 1 72  ? 30.85231 -36.42535 -25.85628 1.000 30.22016 ?  606  TYR   A CE1 1 
ATOM   563  C  CE2 . TYR   A 1 72  ? 30.80277 -36.22118 -23.47689 1.000 36.04263 ?  606  TYR   A CE2 1 
ATOM   564  C  CZ  . TYR   A 1 72  ? 30.47723 -35.73708 -24.72285 1.000 31.56585 ?  606  TYR   A CZ  1 
ATOM   565  O  OH  . TYR   A 1 72  ? 29.79050 -34.54889 -24.82875 1.000 25.10300 ?  606  TYR   A OH  1 
ATOM   566  N  N   . ARG   A 1 73  ? 32.79850 -42.18319 -25.88504 1.000 46.14352 ?  607  ARG   A N   1 
ATOM   567  C  CA  . ARG   A 1 73  ? 33.36718 -43.45495 -26.31442 1.000 43.77683 ?  607  ARG   A CA  1 
ATOM   568  C  C   . ARG   A 1 73  ? 34.82919 -43.24878 -26.68558 1.000 45.05397 ?  607  ARG   A C   1 
ATOM   569  O  O   . ARG   A 1 73  ? 35.13796 -42.58899 -27.68386 1.000 40.44376 ?  607  ARG   A O   1 
ATOM   570  C  CB  . ARG   A 1 73  ? 32.55954 -44.02601 -27.47465 1.000 44.32010 ?  607  ARG   A CB  1 
ATOM   571  C  CG  . ARG   A 1 73  ? 31.07130 -43.78947 -27.29822 1.000 49.08065 ?  607  ARG   A CG  1 
ATOM   572  C  CD  . ARG   A 1 73  ? 30.25215 -44.44132 -28.38519 1.000 48.10695 ?  607  ARG   A CD  1 
ATOM   573  N  NE  . ARG   A 1 73  ? 29.01291 -44.99820 -27.85518 1.000 52.77154 ?  607  ARG   A NE  1 
ATOM   574  C  CZ  . ARG   A 1 73  ? 28.86498 -46.25424 -27.45637 1.000 57.80960 ?  607  ARG   A CZ  1 
ATOM   575  N  NH1 . ARG   A 1 73  ? 29.86022 -47.12343 -27.52511 1.000 61.38789 ?  607  ARG   A NH1 1 
ATOM   576  N  NH2 . ARG   A 1 73  ? 27.68824 -46.64869 -26.97833 1.000 56.28318 ?  607  ARG   A NH2 1 
ATOM   577  N  N   . LYS   A 1 74  ? 35.72357 -43.82086 -25.87622 1.000 51.64520 ?  608  LYS   A N   1 
ATOM   578  C  CA  . LYS   A 1 74  ? 37.15556 -43.68348 -26.10826 1.000 50.35120 ?  608  LYS   A CA  1 
ATOM   579  C  C   . LYS   A 1 74  ? 37.58503 -44.28198 -27.44065 1.000 43.12889 ?  608  LYS   A C   1 
ATOM   580  O  O   . LYS   A 1 74  ? 38.64034 -43.90891 -27.96449 1.000 48.10022 ?  608  LYS   A O   1 
ATOM   581  C  CB  . LYS   A 1 74  ? 37.92730 -44.34244 -24.96308 1.000 49.11050 ?  608  LYS   A CB  1 
ATOM   582  C  CG  . LYS   A 1 74  ? 37.18620 -44.32355 -23.63358 1.000 51.23252 ?  608  LYS   A CG  1 
ATOM   583  C  CD  . LYS   A 1 74  ? 38.14693 -44.37450 -22.45613 1.000 57.08899 ?  608  LYS   A CD  1 
ATOM   584  C  CE  . LYS   A 1 74  ? 37.44288 -44.02641 -21.15304 1.000 57.01342 ?  608  LYS   A CE  1 
ATOM   585  N  NZ  . LYS   A 1 74  ? 36.38999 -45.01818 -20.79718 1.000 51.04699 ?  608  LYS   A NZ  1 
ATOM   586  N  N   . ASN   A 1 75  ? 36.79627 -45.20025 -27.99765 1.000 36.70310 ?  609  ASN   A N   1 
ATOM   587  C  CA  . ASN   A 1 75  ? 37.11643 -45.83392 -29.27020 1.000 41.98667 ?  609  ASN   A CA  1 
ATOM   588  C  C   . ASN   A 1 75  ? 36.70504 -44.99887 -30.47643 1.000 42.40782 ?  609  ASN   A C   1 
ATOM   589  O  O   . ASN   A 1 75  ? 36.93464 -45.43003 -31.61160 1.000 39.52349 ?  609  ASN   A O   1 
ATOM   590  C  CB  . ASN   A 1 75  ? 36.45490 -47.21315 -29.35004 1.000 41.91435 ?  609  ASN   A CB  1 
ATOM   591  C  CG  . ASN   A 1 75  ? 34.98148 -47.17507 -28.99199 1.000 54.51477 ?  609  ASN   A CG  1 
ATOM   592  O  OD1 . ASN   A 1 75  ? 34.61555 -47.17706 -27.81636 1.000 56.10798 ?  609  ASN   A OD1 1 
ATOM   593  N  ND2 . ASN   A 1 75  ? 34.12642 -47.14116 -30.00825 1.000 48.31777 ?  609  ASN   A ND2 1 
ATOM   594  N  N   . VAL   A 1 76  ? 36.10240 -43.83221 -30.26811 1.000 42.40550 ?  610  VAL   A N   1 
ATOM   595  C  CA  . VAL   A 1 76  ? 35.74067 -42.92449 -31.35130 1.000 33.16516 ?  610  VAL   A CA  1 
ATOM   596  C  C   . VAL   A 1 76  ? 36.83117 -41.86720 -31.45323 1.000 33.02075 ?  610  VAL   A C   1 
ATOM   597  O  O   . VAL   A 1 76  ? 37.14790 -41.19464 -30.46406 1.000 35.09743 ?  610  VAL   A O   1 
ATOM   598  C  CB  . VAL   A 1 76  ? 34.35997 -42.29232 -31.11904 1.000 30.78267 ?  610  VAL   A CB  1 
ATOM   599  C  CG1 . VAL   A 1 76  ? 33.98504 -41.39978 -32.28828 1.000 36.58138 ?  610  VAL   A CG1 1 
ATOM   600  C  CG2 . VAL   A 1 76  ? 33.31609 -43.38096 -30.92953 1.000 35.04427 ?  610  VAL   A CG2 1 
ATOM   601  N  N   . ALA   A 1 77  ? 37.39294 -41.71471 -32.65499 1.000 35.23419 ?  611  ALA   A N   1 
ATOM   602  C  CA  . ALA   A 1 77  ? 38.64974 -40.98867 -32.82259 1.000 35.60186 ?  611  ALA   A CA  1 
ATOM   603  C  C   . ALA   A 1 77  ? 38.54615 -39.55011 -32.32443 1.000 38.15052 ?  611  ALA   A C   1 
ATOM   604  O  O   . ALA   A 1 77  ? 39.31392 -39.12307 -31.45436 1.000 33.21474 ?  611  ALA   A O   1 
ATOM   605  C  CB  . ALA   A 1 77  ? 39.07323 -41.02204 -34.29271 1.000 39.21387 ?  611  ALA   A CB  1 
ATOM   606  N  N   . TYR   A 1 78  ? 37.60252 -38.78339 -32.86764 1.000 36.95835 ?  612  TYR   A N   1 
ATOM   607  C  CA  . TYR   A 1 78  ? 37.50767 -37.35680 -32.58663 1.000 30.29112 ?  612  TYR   A CA  1 
ATOM   608  C  C   . TYR   A 1 78  ? 36.33596 -37.00231 -31.68448 1.000 33.12926 ?  612  TYR   A C   1 
ATOM   609  O  O   . TYR   A 1 78  ? 36.50309 -36.24811 -30.72007 1.000 36.11463 ?  612  TYR   A O   1 
ATOM   610  C  CB  . TYR   A 1 78  ? 37.40893 -36.57708 -33.90648 1.000 28.94220 ?  612  TYR   A CB  1 
ATOM   611  C  CG  . TYR   A 1 78  ? 37.06568 -35.11399 -33.74283 1.000 23.09814 ?  612  TYR   A CG  1 
ATOM   612  C  CD1 . TYR   A 1 78  ? 38.02596 -34.19518 -33.34152 1.000 18.01034 ?  612  TYR   A CD1 1 
ATOM   613  C  CD2 . TYR   A 1 78  ? 35.78190 -34.65023 -33.99861 1.000 26.55384 ?  612  TYR   A CD2 1 
ATOM   614  C  CE1 . TYR   A 1 78  ? 37.71672 -32.85701 -33.19637 1.000 24.70487 ?  612  TYR   A CE1 1 
ATOM   615  C  CE2 . TYR   A 1 78  ? 35.46175 -33.31354 -33.85516 1.000 24.42716 ?  612  TYR   A CE2 1 
ATOM   616  C  CZ  . TYR   A 1 78  ? 36.43307 -32.42154 -33.45424 1.000 28.45380 ?  612  TYR   A CZ  1 
ATOM   617  O  OH  . TYR   A 1 78  ? 36.12265 -31.08803 -33.30996 1.000 31.20054 ?  612  TYR   A OH  1 
ATOM   618  N  N   . HIS   A 1 79  ? 35.14440 -37.52664 -31.97200 1.000 31.40328 ?  613  HIS   A N   1 
ATOM   619  C  CA  . HIS   A 1 79  ? 33.94121 -37.17900 -31.21570 1.000 30.62362 ?  613  HIS   A CA  1 
ATOM   620  C  C   . HIS   A 1 79  ? 33.93015 -37.98970 -29.92176 1.000 36.11928 ?  613  HIS   A C   1 
ATOM   621  O  O   . HIS   A 1 79  ? 33.25464 -39.01361 -29.78331 1.000 31.95237 ?  613  HIS   A O   1 
ATOM   622  C  CB  . HIS   A 1 79  ? 32.69958 -37.41409 -32.06432 1.000 28.45689 ?  613  HIS   A CB  1 
ATOM   623  C  CG  . HIS   A 1 79  ? 32.62370 -36.52716 -33.26771 1.000 34.45766 ?  613  HIS   A CG  1 
ATOM   624  N  ND1 . HIS   A 1 79  ? 32.88068 -36.97859 -34.54453 1.000 35.72217 ?  613  HIS   A ND1 1 
ATOM   625  C  CD2 . HIS   A 1 79  ? 32.33920 -35.20904 -33.38516 1.000 30.85472 ?  613  HIS   A CD2 1 
ATOM   626  C  CE1 . HIS   A 1 79  ? 32.74511 -35.97958 -35.39812 1.000 29.33478 ?  613  HIS   A CE1 1 
ATOM   627  N  NE2 . HIS   A 1 79  ? 32.41702 -34.89452 -34.72017 1.000 30.18913 ?  613  HIS   A NE2 1 
ATOM   628  N  N   . ASN   A 1 80  ? 34.70780 -37.50244 -28.95523 1.000 34.89633 ?  614  ASN   A N   1 
ATOM   629  C  CA  . ASN   A 1 80  ? 34.94141 -38.17830 -27.68931 1.000 31.74515 ?  614  ASN   A CA  1 
ATOM   630  C  C   . ASN   A 1 80  ? 35.00162 -37.13531 -26.57910 1.000 29.70240 ?  614  ASN   A C   1 
ATOM   631  O  O   . ASN   A 1 80  ? 34.80406 -35.93864 -26.81257 1.000 30.89263 ?  614  ASN   A O   1 
ATOM   632  C  CB  . ASN   A 1 80  ? 36.22294 -39.01875 -27.75607 1.000 31.98715 ?  614  ASN   A CB  1 
ATOM   633  C  CG  . ASN   A 1 80  ? 37.41123 -38.22928 -28.27223 1.000 31.05610 ?  614  ASN   A CG  1 
ATOM   634  O  OD1 . ASN   A 1 80  ? 37.72678 -37.15314 -27.76659 1.000 29.71796 ?  614  ASN   A OD1 1 
ATOM   635  N  ND2 . ASN   A 1 80  ? 38.06986 -38.75792 -29.29558 1.000 34.21151 ?  614  ASN   A ND2 1 
ATOM   636  N  N   . TRP   A 1 81  ? 35.28599 -37.59867 -25.35762 1.000 28.34964 ?  615  TRP   A N   1 
ATOM   637  C  CA  . TRP   A 1 81  ? 35.29999 -36.70295 -24.20423 1.000 29.49266 ?  615  TRP   A CA  1 
ATOM   638  C  C   . TRP   A 1 81  ? 36.31011 -35.57395 -24.37054 1.000 31.94733 ?  615  TRP   A C   1 
ATOM   639  O  O   . TRP   A 1 81  ? 36.08384 -34.46386 -23.87460 1.000 34.76988 ?  615  TRP   A O   1 
ATOM   640  C  CB  . TRP   A 1 81  ? 35.59755 -37.49330 -22.93071 1.000 30.87642 ?  615  TRP   A CB  1 
ATOM   641  C  CG  . TRP   A 1 81  ? 36.12517 -36.64329 -21.82030 1.000 30.01595 ?  615  TRP   A CG  1 
ATOM   642  C  CD1 . TRP   A 1 81  ? 37.39515 -36.64031 -21.32221 1.000 30.94638 ?  615  TRP   A CD1 1 
ATOM   643  C  CD2 . TRP   A 1 81  ? 35.39731 -35.66326 -21.07140 1.000 33.79600 ?  615  TRP   A CD2 1 
ATOM   644  N  NE1 . TRP   A 1 81  ? 37.50287 -35.72022 -20.30705 1.000 34.62110 ?  615  TRP   A NE1 1 
ATOM   645  C  CE2 . TRP   A 1 81  ? 36.28963 -35.10682 -20.13403 1.000 33.62190 ?  615  TRP   A CE2 1 
ATOM   646  C  CE3 . TRP   A 1 81  ? 34.07705 -35.20281 -21.10216 1.000 35.53856 ?  615  TRP   A CE3 1 
ATOM   647  C  CZ2 . TRP   A 1 81  ? 35.90422 -34.11341 -19.23508 1.000 30.33883 ?  615  TRP   A CZ2 1 
ATOM   648  C  CZ3 . TRP   A 1 81  ? 33.69635 -34.21689 -20.20915 1.000 31.44528 ?  615  TRP   A CZ3 1 
ATOM   649  C  CH2 . TRP   A 1 81  ? 34.60682 -33.68322 -19.28831 1.000 32.31480 ?  615  TRP   A CH2 1 
ATOM   650  N  N   . ARG   A 1 82  ? 37.42463 -35.83309 -25.06000 1.000 32.82066 ?  616  ARG   A N   1 
ATOM   651  C  CA  . ARG   A 1 82  ? 38.41308 -34.78266 -25.28392 1.000 29.27774 ?  616  ARG   A CA  1 
ATOM   652  C  C   . ARG   A 1 82  ? 37.82769 -33.64258 -26.10854 1.000 26.74900 ?  616  ARG   A C   1 
ATOM   653  O  O   . ARG   A 1 82  ? 38.09308 -32.46678 -25.83137 1.000 30.50369 ?  616  ARG   A O   1 
ATOM   654  C  CB  . ARG   A 1 82  ? 39.65145 -35.36053 -25.96790 1.000 29.50565 ?  616  ARG   A CB  1 
ATOM   655  C  CG  . ARG   A 1 82  ? 40.55217 -36.17461 -25.05221 1.000 28.12795 ?  616  ARG   A CG  1 
ATOM   656  C  CD  . ARG   A 1 82  ? 40.73648 -35.50891 -23.69932 1.000 27.87349 ?  616  ARG   A CD  1 
ATOM   657  N  NE  . ARG   A 1 82  ? 41.18413 -36.45901 -22.68871 1.000 36.05579 ?  616  ARG   A NE  1 
ATOM   658  C  CZ  . ARG   A 1 82  ? 42.34235 -36.37725 -22.04919 1.000 34.71270 ?  616  ARG   A CZ  1 
ATOM   659  N  NH1 . ARG   A 1 82  ? 43.19572 -35.39520 -22.28901 1.000 37.46850 ?  616  ARG   A NH1 1 
ATOM   660  N  NH2 . ARG   A 1 82  ? 42.65312 -37.30468 -21.14828 1.000 31.07018 ?  616  ARG   A NH2 1 
ATOM   661  N  N   . HIS   A 1 83  ? 37.03006 -33.96950 -27.12944 1.000 26.34352 ?  617  HIS   A N   1 
ATOM   662  C  CA  . HIS   A 1 83  ? 36.33821 -32.92828 -27.88395 1.000 26.38891 ?  617  HIS   A CA  1 
ATOM   663  C  C   . HIS   A 1 83  ? 35.30238 -32.22379 -27.01869 1.000 25.25917 ?  617  HIS   A C   1 
ATOM   664  O  O   . HIS   A 1 83  ? 35.14187 -31.00101 -27.10569 1.000 23.21054 ?  617  HIS   A O   1 
ATOM   665  C  CB  . HIS   A 1 83  ? 35.67662 -33.52162 -29.12921 1.000 26.78229 ?  617  HIS   A CB  1 
ATOM   666  C  CG  . HIS   A 1 83  ? 34.69424 -32.60300 -29.79260 1.000 25.71484 ?  617  HIS   A CG  1 
ATOM   667  N  ND1 . HIS   A 1 83  ? 35.04059 -31.35358 -30.26071 1.000 24.47404 ?  617  HIS   A ND1 1 
ATOM   668  C  CD2 . HIS   A 1 83  ? 33.37558 -32.75337 -30.06526 1.000 26.71666 ?  617  HIS   A CD2 1 
ATOM   669  C  CE1 . HIS   A 1 83  ? 33.97915 -30.77515 -30.79444 1.000 24.69764 ?  617  HIS   A CE1 1 
ATOM   670  N  NE2 . HIS   A 1 83  ? 32.95522 -31.60297 -30.68820 1.000 23.09673 ?  617  HIS   A NE2 1 
ATOM   671  N  N   . ALA   A 1 84  ? 34.58741 -32.97828 -26.18075 1.000 29.75160 ?  618  ALA   A N   1 
ATOM   672  C  CA  . ALA   A 1 84  ? 33.62482 -32.36444 -25.27219 1.000 26.71921 ?  618  ALA   A CA  1 
ATOM   673  C  C   . ALA   A 1 84  ? 34.32953 -31.47961 -24.25418 1.000 25.44550 ?  618  ALA   A C   1 
ATOM   674  O  O   . ALA   A 1 84  ? 33.89535 -30.35351 -23.98376 1.000 27.00799 ?  618  ALA   A O   1 
ATOM   675  C  CB  . ALA   A 1 84  ? 32.80646 -33.44319 -24.56857 1.000 29.15880 ?  618  ALA   A CB  1 
ATOM   676  N  N   . PHE   A 1 85  ? 35.42497 -31.98098 -23.67709 1.000 24.25358 ?  619  PHE   A N   1 
ATOM   677  C  CA  . PHE   A 1 85  ? 36.22796 -31.17326 -22.76565 1.000 29.13142 ?  619  PHE   A CA  1 
ATOM   678  C  C   . PHE   A 1 85  ? 36.70840 -29.89218 -23.43590 1.000 27.48609 ?  619  PHE   A C   1 
ATOM   679  O  O   . PHE   A 1 85  ? 36.67905 -28.81529 -22.82806 1.000 24.55138 ?  619  PHE   A O   1 
ATOM   680  C  CB  . PHE   A 1 85  ? 37.41944 -31.98724 -22.26320 1.000 31.37808 ?  619  PHE   A CB  1 
ATOM   681  C  CG  . PHE   A 1 85  ? 38.38057 -31.19688 -21.42968 1.000 36.97265 ?  619  PHE   A CG  1 
ATOM   682  C  CD1 . PHE   A 1 85  ? 37.98050 -30.63592 -20.22809 1.000 30.45836 ?  619  PHE   A CD1 1 
ATOM   683  C  CD2 . PHE   A 1 85  ? 39.68291 -31.00294 -21.85465 1.000 34.16063 ?  619  PHE   A CD2 1 
ATOM   684  C  CE1 . PHE   A 1 85  ? 38.86879 -29.89820 -19.46471 1.000 30.51735 ?  619  PHE   A CE1 1 
ATOM   685  C  CE2 . PHE   A 1 85  ? 40.57261 -30.26974 -21.09889 1.000 32.00290 ?  619  PHE   A CE2 1 
ATOM   686  C  CZ  . PHE   A 1 85  ? 40.16758 -29.71634 -19.90406 1.000 30.97267 ?  619  PHE   A CZ  1 
ATOM   687  N  N   . ASN   A 1 86  ? 37.14130 -29.98695 -24.69494 1.000 30.72998 ?  620  ASN   A N   1 
ATOM   688  C  CA  . ASN   A 1 86  ? 37.72744 -28.83202 -25.36594 1.000 26.37308 ?  620  ASN   A CA  1 
ATOM   689  C  C   . ASN   A 1 86  ? 36.66098 -27.81699 -25.76232 1.000 25.94267 ?  620  ASN   A C   1 
ATOM   690  O  O   . ASN   A 1 86  ? 36.88040 -26.60491 -25.64799 1.000 25.47084 ?  620  ASN   A O   1 
ATOM   691  C  CB  . ASN   A 1 86  ? 38.52464 -29.29349 -26.58505 1.000 22.96820 ?  620  ASN   A CB  1 
ATOM   692  C  CG  . ASN   A 1 86  ? 40.01221 -29.41496 -26.29800 1.000 23.09809 ?  620  ASN   A CG  1 
ATOM   693  O  OD1 . ASN   A 1 86  ? 40.61231 -28.53165 -25.68500 1.000 34.15798 ?  620  ASN   A OD1 1 
ATOM   694  N  ND2 . ASN   A 1 86  ? 40.61303 -30.51389 -26.73928 1.000 18.63801 ?  620  ASN   A ND2 1 
ATOM   695  N  N   . THR   A 1 87  ? 35.50070 -28.28885 -26.23176 1.000 27.87010 ?  621  THR   A N   1 
ATOM   696  C  CA  . THR   A 1 87  ? 34.40608 -27.37245 -26.54072 1.000 23.70909 ?  621  THR   A CA  1 
ATOM   697  C  C   . THR   A 1 87  ? 33.95192 -26.61762 -25.29857 1.000 24.25404 ?  621  THR   A C   1 
ATOM   698  O  O   . THR   A 1 87  ? 33.54283 -25.45410 -25.39097 1.000 29.69134 ?  621  THR   A O   1 
ATOM   699  C  CB  . THR   A 1 87  ? 33.23391 -28.13598 -27.16328 1.000 23.07075 ?  621  THR   A CB  1 
ATOM   700  O  OG1 . THR   A 1 87  ? 33.68434 -28.84093 -28.32665 1.000 27.22864 ?  621  THR   A OG1 1 
ATOM   701  C  CG2 . THR   A 1 87  ? 32.11496 -27.18060 -27.56890 1.000 26.48868 ?  621  THR   A CG2 1 
ATOM   702  N  N   . ALA   A 1 88  ? 34.03060 -27.25612 -24.13003 1.000 26.77952 ?  622  ALA   A N   1 
ATOM   703  C  CA  . ALA   A 1 88  ? 33.72846 -26.57261 -22.87871 1.000 23.79343 ?  622  ALA   A CA  1 
ATOM   704  C  C   . ALA   A 1 88  ? 34.84040 -25.61126 -22.47817 1.000 28.82146 ?  622  ALA   A C   1 
ATOM   705  O  O   . ALA   A 1 88  ? 34.56864 -24.55591 -21.89490 1.000 34.63633 ?  622  ALA   A O   1 
ATOM   706  C  CB  . ALA   A 1 88  ? 33.49254 -27.59240 -21.76810 1.000 19.33575 ?  622  ALA   A CB  1 
ATOM   707  N  N   . GLN   A 1 89  ? 36.09563 -25.95909 -22.77121 1.000 24.39162 ?  623  GLN   A N   1 
ATOM   708  C  CA  . GLN   A 1 89  ? 37.20244 -25.07775 -22.41260 1.000 20.87025 ?  623  GLN   A CA  1 
ATOM   709  C  C   . GLN   A 1 89  ? 37.14400 -23.77903 -23.20383 1.000 28.77230 ?  623  GLN   A C   1 
ATOM   710  O  O   . GLN   A 1 89  ? 37.24255 -22.68703 -22.63358 1.000 36.87352 ?  623  GLN   A O   1 
ATOM   711  C  CB  . GLN   A 1 89  ? 38.54099 -25.77968 -22.63823 1.000 27.76157 ?  623  GLN   A CB  1 
ATOM   712  C  CG  . GLN   A 1 89  ? 39.74158 -24.95189 -22.19824 1.000 28.87428 ?  623  GLN   A CG  1 
ATOM   713  C  CD  . GLN   A 1 89  ? 40.24248 -24.02388 -23.29029 1.000 26.40446 ?  623  GLN   A CD  1 
ATOM   714  O  OE1 . GLN   A 1 89  ? 40.26074 -24.38713 -24.46599 1.000 33.11738 ?  623  GLN   A OE1 1 
ATOM   715  N  NE2 . GLN   A 1 89  ? 40.64598 -22.81887 -22.90698 1.000 25.00026 ?  623  GLN   A NE2 1 
ATOM   716  N  N   . CYS   A 1 90  ? 37.00631 -23.87919 -24.52824 1.000 26.77268 ?  624  CYS   A N   1 
ATOM   717  C  CA  . CYS   A 1 90  ? 36.87750 -22.67617 -25.34337 1.000 30.09037 ?  624  CYS   A CA  1 
ATOM   718  C  C   . CYS   A 1 90  ? 35.65700 -21.86535 -24.92851 1.000 31.74841 ?  624  CYS   A C   1 
ATOM   719  O  O   . CYS   A 1 90  ? 35.69846 -20.62922 -24.91714 1.000 31.27340 ?  624  CYS   A O   1 
ATOM   720  C  CB  . CYS   A 1 90  ? 36.80127 -23.04323 -26.82299 1.000 26.55702 ?  624  CYS   A CB  1 
ATOM   721  S  SG  . CYS   A 1 90  ? 36.54968 -21.61833 -27.90204 1.000 33.88968 ?  624  CYS   A SG  1 
ATOM   722  N  N   . MET   A 1 91  ? 34.56024 -22.54961 -24.58931 1.000 34.60012 ?  625  MET   A N   1 
ATOM   723  C  CA  . MET   A 1 91  ? 33.41053 -21.89485 -23.97157 1.000 29.20777 ?  625  MET   A CA  1 
ATOM   724  C  C   . MET   A 1 91  ? 33.84019 -21.06423 -22.76874 1.000 35.53248 ?  625  MET   A C   1 
ATOM   725  O  O   . MET   A 1 91  ? 33.44751 -19.90003 -22.62386 1.000 34.82870 ?  625  MET   A O   1 
ATOM   726  C  CB  . MET   A 1 91  ? 32.38289 -22.95103 -23.55593 1.000 30.23626 ?  625  MET   A CB  1 
ATOM   727  C  CG  . MET   A 1 91  ? 31.07680 -22.39790 -23.01856 1.000 29.89054 ?  625  MET   A CG  1 
ATOM   728  S  SD  . MET   A 1 91  ? 30.59933 -20.83253 -23.76713 1.000 38.56809 ?  625  MET   A SD  1 
ATOM   729  C  CE  . MET   A 1 91  ? 29.48564 -21.42181 -25.03346 1.000 24.45480 ?  625  MET   A CE  1 
ATOM   730  N  N   . PHE   A 1 92  ? 34.65988 -21.65423 -21.89609 1.000 32.53086 ?  626  PHE   A N   1 
ATOM   731  C  CA  . PHE   A 1 92  ? 35.18194 -20.92054 -20.74858 1.000 30.88213 ?  626  PHE   A CA  1 
ATOM   732  C  C   . PHE   A 1 92  ? 36.05694 -19.75675 -21.19536 1.000 33.86721 ?  626  PHE   A C   1 
ATOM   733  O  O   . PHE   A 1 92  ? 35.88373 -18.62242 -20.73456 1.000 38.16360 ?  626  PHE   A O   1 
ATOM   734  C  CB  . PHE   A 1 92  ? 35.96657 -21.86700 -19.84045 1.000 34.22924 ?  626  PHE   A CB  1 
ATOM   735  C  CG  . PHE   A 1 92  ? 36.40289 -21.24513 -18.54763 1.000 37.31669 ?  626  PHE   A CG  1 
ATOM   736  C  CD1 . PHE   A 1 92  ? 35.55306 -21.21809 -17.45545 1.000 36.20432 ?  626  PHE   A CD1 1 
ATOM   737  C  CD2 . PHE   A 1 92  ? 37.66500 -20.69028 -18.42299 1.000 42.87058 ?  626  PHE   A CD2 1 
ATOM   738  C  CE1 . PHE   A 1 92  ? 35.95394 -20.64502 -16.26348 1.000 41.72835 ?  626  PHE   A CE1 1 
ATOM   739  C  CE2 . PHE   A 1 92  ? 38.07155 -20.11662 -17.23552 1.000 37.87781 ?  626  PHE   A CE2 1 
ATOM   740  C  CZ  . PHE   A 1 92  ? 37.21586 -20.09370 -16.15429 1.000 42.65365 ?  626  PHE   A CZ  1 
ATOM   741  N  N   . ALA   A 1 93  ? 37.00639 -20.02194 -22.09728 1.000 35.25763 ?  627  ALA   A N   1 
ATOM   742  C  CA  . ALA   A 1 93  ? 37.90411 -18.96867 -22.56141 1.000 38.08465 ?  627  ALA   A CA  1 
ATOM   743  C  C   . ALA   A 1 93  ? 37.13229 -17.84091 -23.23522 1.000 42.65502 ?  627  ALA   A C   1 
ATOM   744  O  O   . ALA   A 1 93  ? 37.50100 -16.66645 -23.11385 1.000 39.50521 ?  627  ALA   A O   1 
ATOM   745  C  CB  . ALA   A 1 93  ? 38.94769 -19.55167 -23.51426 1.000 29.69324 ?  627  ALA   A CB  1 
ATOM   746  N  N   . ALA   A 1 94  ? 36.05446 -18.17828 -23.94758 1.000 42.34309 ?  628  ALA   A N   1 
ATOM   747  C  CA  . ALA   A 1 94  ? 35.22338 -17.14968 -24.56339 1.000 40.59232 ?  628  ALA   A CA  1 
ATOM   748  C  C   . ALA   A 1 94  ? 34.50323 -16.32151 -23.50859 1.000 45.53358 ?  628  ALA   A C   1 
ATOM   749  O  O   . ALA   A 1 94  ? 34.32793 -15.10889 -23.67450 1.000 48.66342 ?  628  ALA   A O   1 
ATOM   750  C  CB  . ALA   A 1 94  ? 34.21688 -17.78906 -25.51973 1.000 32.47997 ?  628  ALA   A CB  1 
ATOM   751  N  N   . LEU   A 1 95  ? 34.08447 -16.95854 -22.41438 1.000 47.20362 ?  629  LEU   A N   1 
ATOM   752  C  CA  . LEU   A 1 95  ? 33.35846 -16.24342 -21.37129 1.000 49.19711 ?  629  LEU   A CA  1 
ATOM   753  C  C   . LEU   A 1 95  ? 34.27926 -15.30176 -20.60435 1.000 49.36354 ?  629  LEU   A C   1 
ATOM   754  O  O   . LEU   A 1 95  ? 33.92795 -14.14389 -20.35334 1.000 52.23645 ?  629  LEU   A O   1 
ATOM   755  C  CB  . LEU   A 1 95  ? 32.69230 -17.24138 -20.42448 1.000 44.76197 ?  629  LEU   A CB  1 
ATOM   756  C  CG  . LEU   A 1 95  ? 31.41145 -17.89417 -20.94847 1.000 41.88905 ?  629  LEU   A CG  1 
ATOM   757  C  CD1 . LEU   A 1 95  ? 30.90636 -18.94499 -19.97558 1.000 35.41985 ?  629  LEU   A CD1 1 
ATOM   758  C  CD2 . LEU   A 1 95  ? 30.33897 -16.85117 -21.21342 1.000 43.76605 ?  629  LEU   A CD2 1 
ATOM   759  N  N   . LYS   A 1 96  ? 35.46440 -15.77558 -20.22539 1.000 53.98910 ?  630  LYS   A N   1 
ATOM   760  C  CA  . LYS   A 1 96  ? 36.38451 -14.96126 -19.42219 1.000 54.27523 ?  630  LYS   A CA  1 
ATOM   761  C  C   . LYS   A 1 96  ? 37.28416 -14.11278 -20.31570 1.000 47.91587 ?  630  LYS   A C   1 
ATOM   762  O  O   . LYS   A 1 96  ? 37.14115 -12.88800 -20.37223 1.000 49.10846 ?  630  LYS   A O   1 
ATOM   763  C  CB  . LYS   A 1 96  ? 37.21455 -15.85262 -18.49602 1.000 47.97547 ?  630  LYS   A CB  1 
ATOM   764  C  CG  . LYS   A 1 96  ? 36.42601 -16.96148 -17.82899 1.000 49.14990 ?  630  LYS   A CG  1 
ATOM   765  C  CD  . LYS   A 1 96  ? 35.37613 -16.39753 -16.88943 1.000 50.62899 ?  630  LYS   A CD  1 
ATOM   766  C  CE  . LYS   A 1 96  ? 35.95866 -16.13993 -15.50786 1.000 51.18784 ?  630  LYS   A CE  1 
ATOM   767  N  NZ  . LYS   A 1 96  ? 35.32625 -14.97708 -14.82477 1.000 49.35529 ?  630  LYS   A NZ  1 
ATOM   768  N  N   . ALA   A 1 97  ? 38.21780 -14.76099 -21.01833 1.000 46.83009 ?  631  ALA   A N   1 
ATOM   769  C  CA  . ALA   A 1 97  ? 39.20204 -14.02775 -21.80782 1.000 52.88407 ?  631  ALA   A CA  1 
ATOM   770  C  C   . ALA   A 1 97  ? 38.54708 -13.19641 -22.90287 1.000 53.21876 ?  631  ALA   A C   1 
ATOM   771  O  O   . ALA   A 1 97  ? 39.10520 -12.17683 -23.32460 1.000 49.81017 ?  631  ALA   A O   1 
ATOM   772  C  CB  . ALA   A 1 97  ? 40.21714 -15.00031 -22.41012 1.000 46.42759 ?  631  ALA   A CB  1 
ATOM   773  N  N   . GLY   A 1 98  ? 37.37053 -13.60422 -23.36661 1.000 51.82034 ?  632  GLY   A N   1 
ATOM   774  C  CA  . GLY   A 1 98  ? 36.64154 -12.89641 -24.39545 1.000 50.42415 ?  632  GLY   A CA  1 
ATOM   775  C  C   . GLY   A 1 98  ? 35.65567 -11.85994 -23.90268 1.000 54.32249 ?  632  GLY   A C   1 
ATOM   776  O  O   . GLY   A 1 98  ? 34.90179 -11.31575 -24.71713 1.000 51.89244 ?  632  GLY   A O   1 
ATOM   777  N  N   . LYS   A 1 99  ? 35.62653 -11.58065 -22.59846 1.000 51.51984 ?  633  LYS   A N   1 
ATOM   778  C  CA  . LYS   A 1 99  ? 34.76193 -10.57802 -21.97786 1.000 48.99573 ?  633  LYS   A CA  1 
ATOM   779  C  C   . LYS   A 1 99  ? 33.27574 -10.89810 -22.11742 1.000 56.69713 ?  633  LYS   A C   1 
ATOM   780  O  O   . LYS   A 1 99  ? 32.43363 -10.06868 -21.75521 1.000 56.20602 ?  633  LYS   A O   1 
ATOM   781  C  CB  . LYS   A 1 99  ? 35.03264 -9.17375  -22.54103 1.000 53.25409 ?  633  LYS   A CB  1 
ATOM   782  C  CG  . LYS   A 1 99  ? 35.99969 -8.31487  -21.73698 1.000 57.42483 ?  633  LYS   A CG  1 
ATOM   783  C  CD  . LYS   A 1 99  ? 37.31563 -9.02554  -21.45491 1.000 51.92511 ?  633  LYS   A CD  1 
ATOM   784  C  CE  . LYS   A 1 99  ? 38.17066 -8.22131  -20.48642 1.000 53.34102 ?  633  LYS   A CE  1 
ATOM   785  N  NZ  . LYS   A 1 99  ? 38.93193 -9.09091  -19.55056 1.000 54.46703 ?  633  LYS   A NZ  1 
ATOM   786  N  N   . ILE   A 1 100 ? 32.92646 -12.08040 -22.63087 1.000 51.08866 ?  634  ILE   A N   1 
ATOM   787  C  CA  . ILE   A 1 100 ? 31.53627 -12.37315 -22.96339 1.000 47.51126 ?  634  ILE   A CA  1 
ATOM   788  C  C   . ILE   A 1 100 ? 30.68516 -12.62026 -21.71816 1.000 49.29724 ?  634  ILE   A C   1 
ATOM   789  O  O   . ILE   A 1 100 ? 29.45953 -12.45115 -21.76849 1.000 47.43088 ?  634  ILE   A O   1 
ATOM   790  C  CB  . ILE   A 1 100 ? 31.50976 -13.55520 -23.95724 1.000 46.19268 ?  634  ILE   A CB  1 
ATOM   791  C  CG1 . ILE   A 1 100 ? 31.67449 -13.03730 -25.38644 1.000 48.08922 ?  634  ILE   A CG1 1 
ATOM   792  C  CG2 . ILE   A 1 100 ? 30.23388 -14.37589 -23.85430 1.000 41.00158 ?  634  ILE   A CG2 1 
ATOM   793  C  CD1 . ILE   A 1 100 ? 31.64993 -14.12199 -26.42893 1.000 41.07706 ?  634  ILE   A CD1 1 
ATOM   794  N  N   . GLN   A 1 101 ? 31.31366 -12.96469 -20.58858 1.000 47.93524 ?  635  GLN   A N   1 
ATOM   795  C  CA  . GLN   A 1 101 ? 30.60111 -13.27708 -19.34896 1.000 45.18528 ?  635  GLN   A CA  1 
ATOM   796  C  C   . GLN   A 1 101 ? 29.49786 -12.27818 -19.00841 1.000 50.14352 ?  635  GLN   A C   1 
ATOM   797  O  O   . GLN   A 1 101 ? 28.38097 -12.66612 -18.64916 1.000 46.76634 ?  635  GLN   A O   1 
ATOM   798  C  CB  . GLN   A 1 101 ? 31.60374 -13.34517 -18.19319 1.000 38.71157 ?  635  GLN   A CB  1 
ATOM   799  C  CG  . GLN   A 1 101 ? 31.18170 -14.23054 -17.03221 1.000 38.27855 ?  635  GLN   A CG  1 
ATOM   800  C  CD  . GLN   A 1 101 ? 32.25705 -14.33038 -15.96738 1.000 55.26911 ?  635  GLN   A CD  1 
ATOM   801  O  OE1 . GLN   A 1 101 ? 33.32049 -13.72166 -16.08692 1.000 53.65213 ?  635  GLN   A OE1 1 
ATOM   802  N  NE2 . GLN   A 1 101 ? 31.98311 -15.09392 -14.91576 1.000 54.66189 ?  635  GLN   A NE2 1 
ATOM   803  N  N   . ASN   A 1 102 ? 29.79630 -10.98251 -19.11775 1.000 52.00385 ?  636  ASN   A N   1 
ATOM   804  C  CA  . ASN   A 1 102 ? 28.90139 -9.94817  -18.61045 1.000 53.40545 ?  636  ASN   A CA  1 
ATOM   805  C  C   . ASN   A 1 102 ? 27.64908 -9.75456  -19.45660 1.000 51.73301 ?  636  ASN   A C   1 
ATOM   806  O  O   . ASN   A 1 102 ? 26.70454 -9.11125  -18.98637 1.000 58.04264 ?  636  ASN   A O   1 
ATOM   807  C  CB  . ASN   A 1 102 ? 29.65861 -8.62481  -18.49880 1.000 52.90035 ?  636  ASN   A CB  1 
ATOM   808  C  CG  . ASN   A 1 102 ? 31.13014 -8.82434  -18.19775 1.000 56.78730 ?  636  ASN   A CG  1 
ATOM   809  O  OD1 . ASN   A 1 102 ? 31.95492 -8.91299  -19.10731 1.000 60.13983 ?  636  ASN   A OD1 1 
ATOM   810  N  ND2 . ASN   A 1 102 ? 31.46644 -8.90490  -16.91561 1.000 51.32989 ?  636  ASN   A ND2 1 
ATOM   811  N  N   . LYS   A 1 103 ? 27.60846 -10.28338 -20.67568 1.000 49.23912 ?  637  LYS   A N   1 
ATOM   812  C  CA  . LYS   A 1 103 ? 26.44683 -10.11783 -21.54000 1.000 52.61793 ?  637  LYS   A CA  1 
ATOM   813  C  C   . LYS   A 1 103 ? 25.38185 -11.18408 -21.32059 1.000 54.99006 ?  637  LYS   A C   1 
ATOM   814  O  O   . LYS   A 1 103 ? 24.32506 -11.12337 -21.95751 1.000 52.80304 ?  637  LYS   A O   1 
ATOM   815  C  CB  . LYS   A 1 103 ? 26.87686 -10.12468 -23.01018 1.000 52.75488 ?  637  LYS   A CB  1 
ATOM   816  C  CG  . LYS   A 1 103 ? 27.83902 -9.01184  -23.38871 1.000 56.28748 ?  637  LYS   A CG  1 
ATOM   817  C  CD  . LYS   A 1 103 ? 28.01323 -8.93424  -24.89683 1.000 51.21296 ?  637  LYS   A CD  1 
ATOM   818  C  CE  . LYS   A 1 103 ? 29.48155 -8.86763  -25.27647 1.000 54.02743 ?  637  LYS   A CE  1 
ATOM   819  N  NZ  . LYS   A 1 103 ? 30.24373 -7.97707  -24.36006 1.000 47.80228 ?  637  LYS   A NZ  1 
ATOM   820  N  N   . LEU   A 1 104 ? 25.62610 -12.14712 -20.43743 1.000 52.78328 ?  638  LEU   A N   1 
ATOM   821  C  CA  . LEU   A 1 104 ? 24.74690 -13.29086 -20.25945 1.000 47.93893 ?  638  LEU   A CA  1 
ATOM   822  C  C   . LEU   A 1 104 ? 24.32009 -13.40950 -18.80384 1.000 48.19544 ?  638  LEU   A C   1 
ATOM   823  O  O   . LEU   A 1 104 ? 25.06032 -13.03268 -17.89026 1.000 49.69245 ?  638  LEU   A O   1 
ATOM   824  C  CB  . LEU   A 1 104 ? 25.43855 -14.58662 -20.69737 1.000 49.51636 ?  638  LEU   A CB  1 
ATOM   825  C  CG  . LEU   A 1 104 ? 26.13031 -14.54793 -22.06087 1.000 47.39710 ?  638  LEU   A CG  1 
ATOM   826  C  CD1 . LEU   A 1 104 ? 26.95038 -15.80627 -22.28347 1.000 39.66665 ?  638  LEU   A CD1 1 
ATOM   827  C  CD2 . LEU   A 1 104 ? 25.11150 -14.36477 -23.17442 1.000 45.20391 ?  638  LEU   A CD2 1 
ATOM   828  N  N   . THR   A 1 105 ? 23.11812 -13.94069 -18.59672 1.000 43.67823 ?  639  THR   A N   1 
ATOM   829  C  CA  . THR   A 1 105 ? 22.65552 -14.25301 -17.25564 1.000 39.92866 ?  639  THR   A CA  1 
ATOM   830  C  C   . THR   A 1 105 ? 23.35220 -15.51147 -16.74066 1.000 43.96486 ?  639  THR   A C   1 
ATOM   831  O  O   . THR   A 1 105 ? 24.05399 -16.21272 -17.47480 1.000 49.36436 ?  639  THR   A O   1 
ATOM   832  C  CB  . THR   A 1 105 ? 21.13717 -14.43345 -17.23442 1.000 38.91838 ?  639  THR   A CB  1 
ATOM   833  O  OG1 . THR   A 1 105 ? 20.78776 -15.65252 -17.90131 1.000 43.63449 ?  639  THR   A OG1 1 
ATOM   834  C  CG2 . THR   A 1 105 ? 20.45231 -13.26316 -17.92914 1.000 34.38370 ?  639  THR   A CG2 1 
ATOM   835  N  N   . ASP   A 1 106 ? 23.14986 -15.79585 -15.45180 1.000 50.60940 ?  640  ASP   A N   1 
ATOM   836  C  CA  . ASP   A 1 106 ? 23.84380 -16.91928 -14.82834 1.000 45.15378 ?  640  ASP   A CA  1 
ATOM   837  C  C   . ASP   A 1 106 ? 23.30565 -18.25486 -15.32766 1.000 42.78063 ?  640  ASP   A C   1 
ATOM   838  O  O   . ASP   A 1 106 ? 24.07950 -19.18751 -15.57349 1.000 39.43692 ?  640  ASP   A O   1 
ATOM   839  C  CB  . ASP   A 1 106 ? 23.73556 -16.82304 -13.30720 1.000 44.80635 ?  640  ASP   A CB  1 
ATOM   840  C  CG  . ASP   A 1 106 ? 24.54908 -15.67643 -12.73957 1.000 54.53435 ?  640  ASP   A CG  1 
ATOM   841  O  OD1 . ASP   A 1 106 ? 25.78933 -15.80580 -12.66790 1.000 50.75573 ?  640  ASP   A OD1 1 
ATOM   842  O  OD2 . ASP   A 1 106 ? 23.94919 -14.64461 -12.36986 1.000 62.93354 ?  640  ASP   A OD2 1 
ATOM   843  N  N   . LEU   A 1 107 ? 21.98432 -18.36839 -15.48354 1.000 44.91121 ?  641  LEU   A N   1 
ATOM   844  C  CA  . LEU   A 1 107 ? 21.41402 -19.58661 -16.04875 1.000 40.13827 ?  641  LEU   A CA  1 
ATOM   845  C  C   . LEU   A 1 107 ? 21.85550 -19.79241 -17.49206 1.000 40.55932 ?  641  LEU   A C   1 
ATOM   846  O  O   . LEU   A 1 107 ? 22.03211 -20.93584 -17.92718 1.000 45.89999 ?  641  LEU   A O   1 
ATOM   847  C  CB  . LEU   A 1 107 ? 19.88974 -19.54678 -15.95809 1.000 39.86500 ?  641  LEU   A CB  1 
ATOM   848  C  CG  . LEU   A 1 107 ? 19.29975 -19.25910 -14.57647 1.000 30.55988 ?  641  LEU   A CG  1 
ATOM   849  C  CD1 . LEU   A 1 107 ? 17.97125 -18.53148 -14.70551 1.000 35.50850 ?  641  LEU   A CD1 1 
ATOM   850  C  CD2 . LEU   A 1 107 ? 19.13876 -20.54085 -13.76969 1.000 37.50049 ?  641  LEU   A CD2 1 
ATOM   851  N  N   . GLU   A 1 108 ? 22.04244 -18.70452 -18.24187 1.000 42.01667 ?  642  GLU   A N   1 
ATOM   852  C  CA  . GLU   A 1 108 ? 22.54593 -18.81791 -19.60656 1.000 37.24440 ?  642  GLU   A CA  1 
ATOM   853  C  C   . GLU   A 1 108 ? 23.96995 -19.35651 -19.62483 1.000 41.46490 ?  642  GLU   A C   1 
ATOM   854  O  O   . GLU   A 1 108 ? 24.32682 -20.15734 -20.49657 1.000 48.32058 ?  642  GLU   A O   1 
ATOM   855  C  CB  . GLU   A 1 108 ? 22.48272 -17.45782 -20.29973 1.000 41.58151 ?  642  GLU   A CB  1 
ATOM   856  C  CG  . GLU   A 1 108 ? 21.11389 -17.09775 -20.84677 1.000 47.98699 ?  642  GLU   A CG  1 
ATOM   857  C  CD  . GLU   A 1 108 ? 20.97486 -15.61515 -21.13858 1.000 48.06481 ?  642  GLU   A CD  1 
ATOM   858  O  OE1 . GLU   A 1 108 ? 21.90536 -14.84836 -20.81030 1.000 43.91733 ?  642  GLU   A OE1 1 
ATOM   859  O  OE2 . GLU   A 1 108 ? 19.93025 -15.21510 -21.69283 1.000 43.26418 ?  642  GLU   A OE2 1 
ATOM   860  N  N   . ILE   A 1 109 ? 24.79677 -18.92325 -18.67316 1.000 37.30895 ?  643  ILE   A N   1 
ATOM   861  C  CA  . ILE   A 1 109 ? 26.17292 -19.40070 -18.59708 1.000 40.62472 ?  643  ILE   A CA  1 
ATOM   862  C  C   . ILE   A 1 109 ? 26.22097 -20.81433 -18.03073 1.000 41.08617 ?  643  ILE   A C   1 
ATOM   863  O  O   . ILE   A 1 109 ? 26.98511 -21.66122 -18.50829 1.000 39.73942 ?  643  ILE   A O   1 
ATOM   864  C  CB  . ILE   A 1 109 ? 27.02202 -18.41916 -17.76709 1.000 51.69829 ?  643  ILE   A CB  1 
ATOM   865  C  CG1 . ILE   A 1 109 ? 27.41686 -17.20851 -18.61539 1.000 45.35863 ?  643  ILE   A CG1 1 
ATOM   866  C  CG2 . ILE   A 1 109 ? 28.26022 -19.10574 -17.20651 1.000 43.93135 ?  643  ILE   A CG2 1 
ATOM   867  C  CD1 . ILE   A 1 109 ? 27.95772 -16.04956 -17.80793 1.000 46.93874 ?  643  ILE   A CD1 1 
ATOM   868  N  N   . LEU   A 1 110 ? 25.40365 -21.09279 -17.01147 1.000 38.52664 ?  644  LEU   A N   1 
ATOM   869  C  CA  . LEU   A 1 110 ? 25.33141 -22.44216 -16.46070 1.000 35.39680 ?  644  LEU   A CA  1 
ATOM   870  C  C   . LEU   A 1 110 ? 24.83322 -23.44439 -17.49612 1.000 35.64369 ?  644  LEU   A C   1 
ATOM   871  O  O   . LEU   A 1 110 ? 25.24778 -24.60937 -17.48235 1.000 32.27653 ?  644  LEU   A O   1 
ATOM   872  C  CB  . LEU   A 1 110 ? 24.43219 -22.44595 -15.22162 1.000 41.67353 ?  644  LEU   A CB  1 
ATOM   873  C  CG  . LEU   A 1 110 ? 23.75964 -23.74731 -14.78393 1.000 33.41106 ?  644  LEU   A CG  1 
ATOM   874  C  CD1 . LEU   A 1 110 ? 24.74800 -24.64107 -14.05985 1.000 34.07473 ?  644  LEU   A CD1 1 
ATOM   875  C  CD2 . LEU   A 1 110 ? 22.56217 -23.44610 -13.89862 1.000 30.20549 ?  644  LEU   A CD2 1 
ATOM   876  N  N   . ALA   A 1 111 ? 23.96350 -23.00939 -18.41133 1.000 35.96214 ?  645  ALA   A N   1 
ATOM   877  C  CA  . ALA   A 1 111 ? 23.44471 -23.90884 -19.43642 1.000 31.80174 ?  645  ALA   A CA  1 
ATOM   878  C  C   . ALA   A 1 111 ? 24.41874 -24.06394 -20.59777 1.000 31.50572 ?  645  ALA   A C   1 
ATOM   879  O  O   . ALA   A 1 111 ? 24.61699 -25.17821 -21.09621 1.000 30.70632 ?  645  ALA   A O   1 
ATOM   880  C  CB  . ALA   A 1 111 ? 22.09471 -23.40569 -19.94302 1.000 35.77367 ?  645  ALA   A CB  1 
ATOM   881  N  N   . LEU   A 1 112 ? 25.02588 -22.95921 -21.04295 1.000 36.88692 ?  646  LEU   A N   1 
ATOM   882  C  CA  . LEU   A 1 112 ? 26.01075 -23.03011 -22.11816 1.000 31.31489 ?  646  LEU   A CA  1 
ATOM   883  C  C   . LEU   A 1 112 ? 27.13226 -23.99910 -21.77319 1.000 31.94603 ?  646  LEU   A C   1 
ATOM   884  O  O   . LEU   A 1 112 ? 27.56989 -24.78343 -22.62314 1.000 29.87424 ?  646  LEU   A O   1 
ATOM   885  C  CB  . LEU   A 1 112 ? 26.59214 -21.64465 -22.39440 1.000 29.76648 ?  646  LEU   A CB  1 
ATOM   886  C  CG  . LEU   A 1 112 ? 25.84461 -20.66520 -23.29627 1.000 31.84719 ?  646  LEU   A CG  1 
ATOM   887  C  CD1 . LEU   A 1 112 ? 26.51828 -19.31015 -23.19952 1.000 38.06621 ?  646  LEU   A CD1 1 
ATOM   888  C  CD2 . LEU   A 1 112 ? 25.81114 -21.15372 -24.73407 1.000 25.85955 ?  646  LEU   A CD2 1 
ATOM   889  N  N   . LEU   A 1 113 ? 27.60901 -23.96210 -20.52656 1.000 29.31972 ?  647  LEU   A N   1 
ATOM   890  C  CA  . LEU   A 1 113 ? 28.72068 -24.82407 -20.14386 1.000 23.65800 ?  647  LEU   A CA  1 
ATOM   891  C  C   . LEU   A 1 113 ? 28.28041 -26.27789 -20.04546 1.000 27.03241 ?  647  LEU   A C   1 
ATOM   892  O  O   . LEU   A 1 113 ? 29.00168 -27.17942 -20.48748 1.000 28.55105 ?  647  LEU   A O   1 
ATOM   893  C  CB  . LEU   A 1 113 ? 29.32381 -24.35173 -18.82270 1.000 27.08513 ?  647  LEU   A CB  1 
ATOM   894  C  CG  . LEU   A 1 113 ? 30.47988 -25.20017 -18.28853 1.000 25.47558 ?  647  LEU   A CG  1 
ATOM   895  C  CD1 . LEU   A 1 113 ? 31.58042 -25.33516 -19.33243 1.000 30.62526 ?  647  LEU   A CD1 1 
ATOM   896  C  CD2 . LEU   A 1 113 ? 31.02540 -24.61920 -16.99509 1.000 28.34766 ?  647  LEU   A CD2 1 
ATOM   897  N  N   . ILE   A 1 114 ? 27.09897 -26.52569 -19.47303 1.000 26.00149 ?  648  ILE   A N   1 
ATOM   898  C  CA  . ILE   A 1 114 ? 26.57702 -27.88898 -19.40509 1.000 24.75558 ?  648  ILE   A CA  1 
ATOM   899  C  C   . ILE   A 1 114 ? 26.31368 -28.42367 -20.80746 1.000 24.63475 ?  648  ILE   A C   1 
ATOM   900  O  O   . ILE   A 1 114 ? 26.57789 -29.59556 -21.10348 1.000 27.18354 ?  648  ILE   A O   1 
ATOM   901  C  CB  . ILE   A 1 114 ? 25.31147 -27.93476 -18.52572 1.000 31.31630 ?  648  ILE   A CB  1 
ATOM   902  C  CG1 . ILE   A 1 114 ? 25.68399 -27.82851 -17.04491 1.000 30.52593 ?  648  ILE   A CG1 1 
ATOM   903  C  CG2 . ILE   A 1 114 ? 24.51369 -29.21250 -18.77866 1.000 32.99768 ?  648  ILE   A CG2 1 
ATOM   904  C  CD1 . ILE   A 1 114 ? 24.50144 -27.57055 -16.13770 1.000 33.66072 ?  648  ILE   A CD1 1 
ATOM   905  N  N   . ALA   A 1 115 ? 25.81067 -27.56697 -21.69898 1.000 26.41882 ?  649  ALA   A N   1 
ATOM   906  C  CA  . ALA   A 1 115 ? 25.55861 -27.98846 -23.07253 1.000 20.05117 ?  649  ALA   A CA  1 
ATOM   907  C  C   . ALA   A 1 115 ? 26.85794 -28.26250 -23.81978 1.000 22.09584 ?  649  ALA   A C   1 
ATOM   908  O  O   . ALA   A 1 115 ? 26.95730 -29.25292 -24.55289 1.000 25.23653 ?  649  ALA   A O   1 
ATOM   909  C  CB  . ALA   A 1 115 ? 24.73266 -26.93216 -23.79930 1.000 25.58264 ?  649  ALA   A CB  1 
ATOM   910  N  N   . ALA   A 1 116 ? 27.86616 -27.40359 -23.64336 1.000 24.15355 ?  650  ALA   A N   1 
ATOM   911  C  CA  . ALA   A 1 116 ? 29.14038 -27.61041 -24.32625 1.000 23.86665 ?  650  ALA   A CA  1 
ATOM   912  C  C   . ALA   A 1 116 ? 29.77692 -28.93358 -23.91894 1.000 24.71096 ?  650  ALA   A C   1 
ATOM   913  O  O   . ALA   A 1 116 ? 30.34675 -29.64321 -24.75674 1.000 18.34296 ?  650  ALA   A O   1 
ATOM   914  C  CB  . ALA   A 1 116 ? 30.08861 -26.44798 -24.03538 1.000 21.78144 ?  650  ALA   A CB  1 
ATOM   915  N  N   . LEU   A 1 117 ? 29.68195 -29.28528 -22.63453 1.000 27.46347 ?  651  LEU   A N   1 
ATOM   916  C  CA  . LEU   A 1 117 ? 30.25588 -30.53838 -22.15689 1.000 21.17910 ?  651  LEU   A CA  1 
ATOM   917  C  C   . LEU   A 1 117 ? 29.49827 -31.74871 -22.68863 1.000 24.06149 ?  651  LEU   A C   1 
ATOM   918  O  O   . LEU   A 1 117 ? 30.08220 -32.82807 -22.83854 1.000 25.71322 ?  651  LEU   A O   1 
ATOM   919  C  CB  . LEU   A 1 117 ? 30.26114 -30.55876 -20.62726 1.000 25.54376 ?  651  LEU   A CB  1 
ATOM   920  C  CG  . LEU   A 1 117 ? 31.41618 -29.87710 -19.89045 1.000 28.30455 ?  651  LEU   A CG  1 
ATOM   921  C  CD1 . LEU   A 1 117 ? 31.07692 -29.67191 -18.41968 1.000 28.45333 ?  651  LEU   A CD1 1 
ATOM   922  C  CD2 . LEU   A 1 117 ? 32.69082 -30.69265 -20.03978 1.000 24.40286 ?  651  LEU   A CD2 1 
ATOM   923  N  N   . SER   A 1 118 ? 28.21019 -31.59045 -22.98641 1.000 27.78056 ?  652  SER   A N   1 
ATOM   924  C  CA  . SER   A 1 118 ? 27.33026 -32.71481 -23.26738 1.000 22.14245 ?  652  SER   A CA  1 
ATOM   925  C  C   . SER   A 1 118 ? 26.86606 -32.78533 -24.71484 1.000 18.70802 ?  652  SER   A C   1 
ATOM   926  O  O   . SER   A 1 118 ? 26.09659 -33.68924 -25.05548 1.000 24.06864 ?  652  SER   A O   1 
ATOM   927  C  CB  . SER   A 1 118 ? 26.10616 -32.65084 -22.34733 1.000 20.85807 ?  652  SER   A CB  1 
ATOM   928  O  OG  . SER   A 1 118 ? 26.48717 -32.43278 -21.00081 1.000 22.97183 ?  652  SER   A OG  1 
ATOM   929  N  N   . HIS   A 1 119 ? 27.31844 -31.87384 -25.57739 1.000 20.20598 ?  653  HIS   A N   1 
ATOM   930  C  CA  . HIS   A 1 119 ? 26.71659 -31.71772 -26.89713 1.000 20.78467 ?  653  HIS   A CA  1 
ATOM   931  C  C   . HIS   A 1 119 ? 26.98871 -32.88438 -27.84021 1.000 23.81538 ?  653  HIS   A C   1 
ATOM   932  O  O   . HIS   A 1 119 ? 26.39333 -32.92386 -28.92137 1.000 27.52246 ?  653  HIS   A O   1 
ATOM   933  C  CB  . HIS   A 1 119 ? 27.20474 -30.41950 -27.54194 1.000 21.94489 ?  653  HIS   A CB  1 
ATOM   934  C  CG  . HIS   A 1 119 ? 28.58631 -30.51067 -28.11056 1.000 26.86793 ?  653  HIS   A CG  1 
ATOM   935  N  ND1 . HIS   A 1 119 ? 29.71576 -30.23485 -27.36998 1.000 21.38010 ?  653  HIS   A ND1 1 
ATOM   936  C  CD2 . HIS   A 1 119 ? 29.02053 -30.84381 -29.34922 1.000 25.79252 ?  653  HIS   A CD2 1 
ATOM   937  C  CE1 . HIS   A 1 119 ? 30.78588 -30.39599 -28.12762 1.000 19.86663 ?  653  HIS   A CE1 1 
ATOM   938  N  NE2 . HIS   A 1 119 ? 30.39175 -30.76509 -29.33300 1.000 20.71621 ?  653  HIS   A NE2 1 
ATOM   939  N  N   . ASP   A 1 120 ? 27.86041 -33.82547 -27.47684 1.000 28.83039 ?  654  ASP   A N   1 
ATOM   940  C  CA  . ASP   A 1 120 ? 28.17846 -34.94652 -28.35583 1.000 29.37228 ?  654  ASP   A CA  1 
ATOM   941  C  C   . ASP   A 1 120 ? 28.16146 -36.27125 -27.60451 1.000 34.94875 ?  654  ASP   A C   1 
ATOM   942  O  O   . ASP   A 1 120 ? 28.83859 -37.22332 -28.00551 1.000 36.02128 ?  654  ASP   A O   1 
ATOM   943  C  CB  . ASP   A 1 120 ? 29.53325 -34.74816 -29.03552 1.000 27.02682 ?  654  ASP   A CB  1 
ATOM   944  C  CG  . ASP   A 1 120 ? 29.40966 -34.11994 -30.40855 1.000 28.61600 ?  654  ASP   A CG  1 
ATOM   945  O  OD1 . ASP   A 1 120 ? 28.41979 -34.41399 -31.10884 1.000 32.94802 ?  654  ASP   A OD1 1 
ATOM   946  O  OD2 . ASP   A 1 120 ? 30.30521 -33.33963 -30.79262 1.000 29.54235 ?  654  ASP   A OD2 1 
ATOM   947  N  N   . LEU   A 1 121 ? 27.39649 -36.34488 -26.51456 1.000 33.21776 ?  655  LEU   A N   1 
ATOM   948  C  CA  . LEU   A 1 121 ? 27.37891 -37.54362 -25.68629 1.000 29.70836 ?  655  LEU   A CA  1 
ATOM   949  C  C   . LEU   A 1 121 ? 26.96621 -38.76234 -26.50154 1.000 35.04128 ?  655  LEU   A C   1 
ATOM   950  O  O   . LEU   A 1 121 ? 26.03421 -38.70518 -27.30947 1.000 36.81681 ?  655  LEU   A O   1 
ATOM   951  C  CB  . LEU   A 1 121 ? 26.42310 -37.36588 -24.50728 1.000 28.26728 ?  655  LEU   A CB  1 
ATOM   952  C  CG  . LEU   A 1 121 ? 26.93089 -36.65965 -23.25241 1.000 26.30433 ?  655  LEU   A CG  1 
ATOM   953  C  CD1 . LEU   A 1 121 ? 25.75284 -36.16254 -22.44838 1.000 26.28558 ?  655  LEU   A CD1 1 
ATOM   954  C  CD2 . LEU   A 1 121 ? 27.78489 -37.59429 -22.42132 1.000 32.64844 ?  655  LEU   A CD2 1 
ATOM   955  N  N   . ASP   A 1 122 ? 27.68659 -39.86712 -26.28909 1.000 35.99580 ?  656  ASP   A N   1 
ATOM   956  C  CA  . ASP   A 1 122 ? 27.41042 -41.15074 -26.93638 1.000 39.44683 ?  656  ASP   A CA  1 
ATOM   957  C  C   . ASP   A 1 122 ? 27.54115 -41.06496 -28.45598 1.000 38.85975 ?  656  ASP   A C   1 
ATOM   958  O  O   . ASP   A 1 122 ? 26.81310 -41.73579 -29.19158 1.000 38.16719 ?  656  ASP   A O   1 
ATOM   959  C  CB  . ASP   A 1 122 ? 26.02918 -41.68504 -26.53937 1.000 38.37722 ?  656  ASP   A CB  1 
ATOM   960  C  CG  . ASP   A 1 122 ? 25.92230 -43.19219 -26.67747 1.000 43.05514 ?  656  ASP   A CG  1 
ATOM   961  O  OD1 . ASP   A 1 122 ? 26.70470 -43.90976 -26.01871 1.000 54.79081 ?  656  ASP   A OD1 1 
ATOM   962  O  OD2 . ASP   A 1 122 ? 25.05323 -43.65908 -27.44414 1.000 40.39547 ?  656  ASP   A OD2 1 
ATOM   963  N  N   . HIS   A 1 123 ? 28.46949 -40.23964 -28.93597 1.000 40.47987 ?  657  HIS   A N   1 
ATOM   964  C  CA  . HIS   A 1 123 ? 28.74125 -40.14823 -30.36564 1.000 40.01193 ?  657  HIS   A CA  1 
ATOM   965  C  C   . HIS   A 1 123 ? 29.45286 -41.41266 -30.83010 1.000 40.93768 ?  657  HIS   A C   1 
ATOM   966  O  O   . HIS   A 1 123 ? 30.52897 -41.74872 -30.32500 1.000 46.56275 ?  657  HIS   A O   1 
ATOM   967  C  CB  . HIS   A 1 123 ? 29.59040 -38.91379 -30.66379 1.000 38.58883 ?  657  HIS   A CB  1 
ATOM   968  C  CG  . HIS   A 1 123 ? 29.46420 -38.41070 -32.06913 1.000 35.31147 ?  657  HIS   A CG  1 
ATOM   969  N  ND1 . HIS   A 1 123 ? 29.79669 -39.17382 -33.16769 1.000 35.68954 ?  657  HIS   A ND1 1 
ATOM   970  C  CD2 . HIS   A 1 123 ? 29.06746 -37.20981 -32.55276 1.000 36.42158 ?  657  HIS   A CD2 1 
ATOM   971  C  CE1 . HIS   A 1 123 ? 29.59539 -38.47069 -34.26793 1.000 33.44981 ?  657  HIS   A CE1 1 
ATOM   972  N  NE2 . HIS   A 1 123 ? 29.15345 -37.27499 -33.92246 1.000 37.06503 ?  657  HIS   A NE2 1 
ATOM   973  N  N   . ARG   A 1 124 ? 28.85096 -42.11741 -31.78655 1.000 41.55059 ?  658  ARG   A N   1 
ATOM   974  C  CA  . ARG   A 1 124 ? 29.42718 -43.35092 -32.30790 1.000 44.92749 ?  658  ARG   A CA  1 
ATOM   975  C  C   . ARG   A 1 124 ? 30.48959 -43.11225 -33.36952 1.000 44.55671 ?  658  ARG   A C   1 
ATOM   976  O  O   . ARG   A 1 124 ? 31.16313 -44.06822 -33.77466 1.000 47.37749 ?  658  ARG   A O   1 
ATOM   977  C  CB  . ARG   A 1 124 ? 28.32765 -44.23209 -32.90283 1.000 51.65515 ?  658  ARG   A CB  1 
ATOM   978  C  CG  . ARG   A 1 124 ? 28.35828 -45.68026 -32.44993 1.000 55.09720 ?  658  ARG   A CG  1 
ATOM   979  C  CD  . ARG   A 1 124 ? 28.27904 -45.77981 -30.94107 1.000 52.62548 ?  658  ARG   A CD  1 
ATOM   980  N  NE  . ARG   A 1 124 ? 26.93783 -45.50919 -30.43778 1.000 54.39427 ?  658  ARG   A NE  1 
ATOM   981  C  CZ  . ARG   A 1 124 ? 26.05070 -46.44527 -30.13086 1.000 59.55432 ?  658  ARG   A CZ  1 
ATOM   982  N  NH1 . ARG   A 1 124 ? 26.33627 -47.73188 -30.24590 1.000 57.83354 ?  658  ARG   A NH1 1 
ATOM   983  N  NH2 . ARG   A 1 124 ? 24.84645 -46.08144 -29.69905 1.000 53.96577 ?  658  ARG   A NH2 1 
ATOM   984  N  N   . GLY   A 1 125 ? 30.66307 -41.88181 -33.81578 1.000 43.03109 ?  659  GLY   A N   1 
ATOM   985  C  CA  . GLY   A 1 125 ? 31.46084 -41.60199 -34.99188 1.000 40.02503 ?  659  GLY   A CA  1 
ATOM   986  C  C   . GLY   A 1 125 ? 30.57289 -41.41712 -36.20972 1.000 40.89519 ?  659  GLY   A C   1 
ATOM   987  O  O   . GLY   A 1 125 ? 29.50879 -42.03266 -36.34037 1.000 47.95888 ?  659  GLY   A O   1 
ATOM   988  N  N   . VAL   A 1 126 ? 31.00215 -40.53587 -37.11184 1.000 48.95842 ?  660  VAL   A N   1 
ATOM   989  C  CA  . VAL   A 1 126 ? 30.18760 -40.11291 -38.25048 1.000 58.21916 ?  660  VAL   A CA  1 
ATOM   990  C  C   . VAL   A 1 126 ? 29.93632 -41.26571 -39.21679 1.000 50.16270 ?  660  VAL   A C   1 
ATOM   991  O  O   . VAL   A 1 126 ? 29.21302 -41.11076 -40.20727 1.000 53.68502 ?  660  VAL   A O   1 
ATOM   992  C  CB  . VAL   A 1 126 ? 30.83757 -38.92092 -38.97856 1.000 48.76609 ?  660  VAL   A CB  1 
ATOM   993  C  CG1 . VAL   A 1 126 ? 30.49785 -37.61799 -38.26980 1.000 39.16861 ?  660  VAL   A CG1 1 
ATOM   994  C  CG2 . VAL   A 1 126 ? 32.34257 -39.10449 -39.08085 1.000 45.64557 ?  660  VAL   A CG2 1 
ATOM   995  N  N   . ASN   A 1 127 ? 30.52001 -42.42720 -38.93576 1.000 47.73862 ?  661  ASN   A N   1 
ATOM   996  C  CA  . ASN   A 1 127 ? 30.31091 -43.62360 -39.74818 1.000 58.30261 ?  661  ASN   A CA  1 
ATOM   997  C  C   . ASN   A 1 127 ? 29.20121 -44.51059 -39.20069 1.000 59.24807 ?  661  ASN   A C   1 
ATOM   998  O  O   . ASN   A 1 127 ? 29.29300 -45.74133 -39.25573 1.000 47.59486 ?  661  ASN   A O   1 
ATOM   999  C  CB  . ASN   A 1 127 ? 31.61932 -44.39707 -39.86601 1.000 63.43259 ?  661  ASN   A CB  1 
ATOM   1000 C  CG  . ASN   A 1 127 ? 32.63075 -43.69104 -40.74455 1.000 63.42894 ?  661  ASN   A CG  1 
ATOM   1001 O  OD1 . ASN   A 1 127 ? 32.30710 -43.23653 -41.84236 1.000 61.04837 ?  661  ASN   A OD1 1 
ATOM   1002 N  ND2 . ASN   A 1 127 ? 33.86199 -43.58453 -40.26011 1.000 65.34401 ?  661  ASN   A ND2 1 
ATOM   1003 N  N   . ASN   A 1 128 ? 28.14071 -43.91090 -38.66782 1.000 62.81030 ?  662  ASN   A N   1 
ATOM   1004 C  CA  . ASN   A 1 128 ? 26.97504 -44.65780 -38.21039 1.000 60.10560 ?  662  ASN   A CA  1 
ATOM   1005 C  C   . ASN   A 1 128 ? 25.68955 -43.95000 -38.62114 1.000 54.45079 ?  662  ASN   A C   1 
ATOM   1006 O  O   . ASN   A 1 128 ? 24.59182 -44.44974 -38.37968 1.000 52.78097 ?  662  ASN   A O   1 
ATOM   1007 C  CB  . ASN   A 1 128 ? 27.00986 -44.84860 -36.69336 1.000 60.49313 ?  662  ASN   A CB  1 
ATOM   1008 C  CG  . ASN   A 1 128 ? 27.99273 -45.91789 -36.26105 1.000 61.53898 ?  662  ASN   A CG  1 
ATOM   1009 O  OD1 . ASN   A 1 128 ? 29.20589 -45.75538 -36.39662 1.000 53.19937 ?  662  ASN   A OD1 1 
ATOM   1010 N  ND2 . ASN   A 1 128 ? 27.47194 -47.02220 -35.74017 1.000 62.68537 ?  662  ASN   A ND2 1 
ATOM   1011 N  N   . SER   A 1 145 ? 17.65759 -32.72932 -36.85671 1.000 40.72437 ?  679  SER   A N   1 
ATOM   1012 C  CA  . SER   A 1 145 ? 18.75030 -32.76225 -35.89551 1.000 42.45149 ?  679  SER   A CA  1 
ATOM   1013 C  C   . SER   A 1 145 ? 18.66314 -34.02716 -35.04994 1.000 40.60994 ?  679  SER   A C   1 
ATOM   1014 O  O   . SER   A 1 145 ? 18.72169 -33.96619 -33.82012 1.000 44.65456 ?  679  SER   A O   1 
ATOM   1015 C  CB  . SER   A 1 145 ? 18.72303 -31.51547 -35.01103 1.000 42.47717 ?  679  SER   A CB  1 
ATOM   1016 O  OG  . SER   A 1 145 ? 18.90141 -30.34768 -35.79493 1.000 44.88040 ?  679  SER   A OG  1 
ATOM   1017 N  N   . ILE   A 1 146 ? 18.52096 -35.16674 -35.73909 1.000 41.71206 ?  680  ILE   A N   1 
ATOM   1018 C  CA  . ILE   A 1 146 ? 18.39336 -36.46451 -35.07095 1.000 40.05394 ?  680  ILE   A CA  1 
ATOM   1019 C  C   . ILE   A 1 146 ? 19.51328 -36.65945 -34.05364 1.000 39.76165 ?  680  ILE   A C   1 
ATOM   1020 O  O   . ILE   A 1 146 ? 19.26920 -36.87013 -32.86155 1.000 33.68603 ?  680  ILE   A O   1 
ATOM   1021 C  CB  . ILE   A 1 146 ? 18.38703 -37.59556 -36.11235 1.000 43.42986 ?  680  ILE   A CB  1 
ATOM   1022 C  CG1 . ILE   A 1 146 ? 19.38787 -37.28629 -37.23294 1.000 47.97497 ?  680  ILE   A CG1 1 
ATOM   1023 C  CG2 . ILE   A 1 146 ? 16.98835 -37.79865 -36.67115 1.000 38.70317 ?  680  ILE   A CG2 1 
ATOM   1024 C  CD1 . ILE   A 1 146 ? 19.91046 -38.50082 -37.93370 1.000 57.79837 ?  680  ILE   A CD1 1 
ATOM   1025 N  N   . MET   A 1 147 ? 20.76115 -36.58212 -34.52301 1.000 44.67209 ?  681  MET   A N   1 
ATOM   1026 C  CA  . MET   A 1 147 ? 21.92813 -36.89697 -33.70316 1.000 35.86298 ?  681  MET   A CA  1 
ATOM   1027 C  C   . MET   A 1 147 ? 21.94013 -36.08871 -32.41359 1.000 37.64012 ?  681  MET   A C   1 
ATOM   1028 O  O   . MET   A 1 147 ? 22.21045 -36.61880 -31.32977 1.000 36.85968 ?  681  MET   A O   1 
ATOM   1029 C  CB  . MET   A 1 147 ? 23.19038 -36.62583 -34.52516 1.000 36.06877 ?  681  MET   A CB  1 
ATOM   1030 C  CG  . MET   A 1 147 ? 23.71645 -37.84531 -35.26052 1.000 43.96229 ?  681  MET   A CG  1 
ATOM   1031 S  SD  . MET   A 1 147 ? 24.83474 -38.81697 -34.24072 1.000 50.58183 ?  681  MET   A SD  1 
ATOM   1032 C  CE  . MET   A 1 147 ? 25.89768 -37.50792 -33.65824 1.000 42.23863 ?  681  MET   A CE  1 
ATOM   1033 N  N   . GLU   A 1 148 ? 21.61749 -34.80197 -32.51614 1.000 34.38312 ?  682  GLU   A N   1 
ATOM   1034 C  CA  . GLU   A 1 148 ? 21.71788 -33.89566 -31.38301 1.000 30.54408 ?  682  GLU   A CA  1 
ATOM   1035 C  C   . GLU   A 1 148 ? 20.58657 -34.09570 -30.38668 1.000 33.94031 ?  682  GLU   A C   1 
ATOM   1036 O  O   . GLU   A 1 148 ? 20.75345 -33.78361 -29.20413 1.000 33.45542 ?  682  GLU   A O   1 
ATOM   1037 C  CB  . GLU   A 1 148 ? 21.74817 -32.45599 -31.89375 1.000 34.97235 ?  682  GLU   A CB  1 
ATOM   1038 C  CG  . GLU   A 1 148 ? 23.02821 -32.11499 -32.64889 1.000 33.97836 ?  682  GLU   A CG  1 
ATOM   1039 C  CD  . GLU   A 1 148 ? 22.99470 -32.56534 -34.10043 1.000 36.60211 ?  682  GLU   A CD  1 
ATOM   1040 O  OE1 . GLU   A 1 148 ? 22.08744 -33.34112 -34.46787 1.000 42.85015 ?  682  GLU   A OE1 1 
ATOM   1041 O  OE2 . GLU   A 1 148 ? 23.89194 -32.17094 -34.87058 1.000 33.05033 ?  682  GLU   A OE2 1 
ATOM   1042 N  N   . HIS   A 1 149 ? 19.43994 -34.61465 -30.83535 1.000 36.31940 ?  683  HIS   A N   1 
ATOM   1043 C  CA  . HIS   A 1 149 ? 18.37716 -34.95511 -29.89447 1.000 31.58392 ?  683  HIS   A CA  1 
ATOM   1044 C  C   . HIS   A 1 149 ? 18.79754 -36.10975 -28.99588 1.000 27.89536 ?  683  HIS   A C   1 
ATOM   1045 O  O   . HIS   A 1 149 ? 18.54376 -36.08694 -27.78540 1.000 36.74357 ?  683  HIS   A O   1 
ATOM   1046 C  CB  . HIS   A 1 149 ? 17.09197 -35.29901 -30.64548 1.000 31.97426 ?  683  HIS   A CB  1 
ATOM   1047 C  CG  . HIS   A 1 149 ? 16.24170 -34.10890 -30.96308 1.000 33.14728 ?  683  HIS   A CG  1 
ATOM   1048 N  ND1 . HIS   A 1 149 ? 16.32349 -33.43613 -32.16314 1.000 38.61099 ?  683  HIS   A ND1 1 
ATOM   1049 C  CD2 . HIS   A 1 149 ? 15.29224 -33.47129 -30.23819 1.000 36.71770 ?  683  HIS   A CD2 1 
ATOM   1050 C  CE1 . HIS   A 1 149 ? 15.46241 -32.43436 -32.16324 1.000 39.32763 ?  683  HIS   A CE1 1 
ATOM   1051 N  NE2 . HIS   A 1 149 ? 14.82391 -32.43368 -31.00696 1.000 36.11685 ?  683  HIS   A NE2 1 
ATOM   1052 N  N   . HIS   A 1 150 ? 19.43359 -37.13148 -29.57524 1.000 30.20768 ?  684  HIS   A N   1 
ATOM   1053 C  CA  . HIS   A 1 150 ? 20.02475 -38.19330 -28.76868 1.000 28.78408 ?  684  HIS   A CA  1 
ATOM   1054 C  C   . HIS   A 1 150 ? 21.05660 -37.62936 -27.80132 1.000 33.13205 ?  684  HIS   A C   1 
ATOM   1055 O  O   . HIS   A 1 150 ? 21.13287 -38.05825 -26.64324 1.000 35.22326 ?  684  HIS   A O   1 
ATOM   1056 C  CB  . HIS   A 1 150 ? 20.66017 -39.24574 -29.67815 1.000 33.10575 ?  684  HIS   A CB  1 
ATOM   1057 C  CG  . HIS   A 1 150 ? 21.16593 -40.45319 -28.95143 1.000 30.99994 ?  684  HIS   A CG  1 
ATOM   1058 N  ND1 . HIS   A 1 150 ? 20.34490 -41.28278 -28.21816 1.000 40.77156 ?  684  HIS   A ND1 1 
ATOM   1059 C  CD2 . HIS   A 1 150 ? 22.41331 -40.96899 -28.84465 1.000 32.76144 ?  684  HIS   A CD2 1 
ATOM   1060 C  CE1 . HIS   A 1 150 ? 21.06459 -42.25847 -27.69280 1.000 41.87537 ?  684  HIS   A CE1 1 
ATOM   1061 N  NE2 . HIS   A 1 150 ? 22.32301 -42.09061 -28.05704 1.000 34.26616 ?  684  HIS   A NE2 1 
ATOM   1062 N  N   . HIS   A 1 151 ? 21.85340 -36.65677 -28.25871 1.000 28.92850 ?  685  HIS   A N   1 
ATOM   1063 C  CA  . HIS   A 1 151 ? 22.84037 -36.02885 -27.38556 1.000 25.12914 ?  685  HIS   A CA  1 
ATOM   1064 C  C   . HIS   A 1 151 ? 22.17834 -35.37986 -26.17931 1.000 28.22635 ?  685  HIS   A C   1 
ATOM   1065 O  O   . HIS   A 1 151 ? 22.66190 -35.51640 -25.04931 1.000 30.07432 ?  685  HIS   A O   1 
ATOM   1066 C  CB  . HIS   A 1 151 ? 23.64821 -34.99105 -28.16067 1.000 29.84951 ?  685  HIS   A CB  1 
ATOM   1067 C  CG  . HIS   A 1 151 ? 24.59088 -35.58115 -29.16073 1.000 33.68260 ?  685  HIS   A CG  1 
ATOM   1068 N  ND1 . HIS   A 1 151 ? 25.20891 -36.79875 -28.97391 1.000 35.10952 ?  685  HIS   A ND1 1 
ATOM   1069 C  CD2 . HIS   A 1 151 ? 25.02184 -35.11954 -30.35853 1.000 30.26202 ?  685  HIS   A CD2 1 
ATOM   1070 C  CE1 . HIS   A 1 151 ? 25.97955 -37.06144 -30.01445 1.000 32.90726 ?  685  HIS   A CE1 1 
ATOM   1071 N  NE2 . HIS   A 1 151 ? 25.88737 -36.05631 -30.86628 1.000 32.08833 ?  685  HIS   A NE2 1 
ATOM   1072 N  N   . PHE   A 1 152 ? 21.07509 -34.66103 -26.39888 1.000 31.05896 ?  686  PHE   A N   1 
ATOM   1073 C  CA  . PHE   A 1 152 ? 20.39518 -34.01307 -25.28367 1.000 28.34183 ?  686  PHE   A CA  1 
ATOM   1074 C  C   . PHE   A 1 152 ? 19.75388 -35.03532 -24.35580 1.000 30.08159 ?  686  PHE   A C   1 
ATOM   1075 O  O   . PHE   A 1 152 ? 19.77685 -34.86617 -23.13138 1.000 31.92715 ?  686  PHE   A O   1 
ATOM   1076 C  CB  . PHE   A 1 152 ? 19.34325 -33.03007 -25.79012 1.000 30.75933 ?  686  PHE   A CB  1 
ATOM   1077 C  CG  . PHE   A 1 152 ? 18.50284 -32.44412 -24.69407 1.000 37.75464 ?  686  PHE   A CG  1 
ATOM   1078 C  CD1 . PHE   A 1 152 ? 18.98722 -31.40695 -23.91434 1.000 27.78492 ?  686  PHE   A CD1 1 
ATOM   1079 C  CD2 . PHE   A 1 152 ? 17.23840 -32.94491 -24.42707 1.000 40.78038 ?  686  PHE   A CD2 1 
ATOM   1080 C  CE1 . PHE   A 1 152 ? 18.22148 -30.87168 -22.89682 1.000 39.29011 ?  686  PHE   A CE1 1 
ATOM   1081 C  CE2 . PHE   A 1 152 ? 16.46965 -32.41594 -23.41097 1.000 37.95925 ?  686  PHE   A CE2 1 
ATOM   1082 C  CZ  . PHE   A 1 152 ? 16.95955 -31.37716 -22.64506 1.000 41.65688 ?  686  PHE   A CZ  1 
ATOM   1083 N  N   . ASP   A 1 153 ? 19.15397 -36.08669 -24.91960 1.000 30.14132 ?  687  ASP   A N   1 
ATOM   1084 C  CA  . ASP   A 1 153 ? 18.58220 -37.14842 -24.09641 1.000 34.82152 ?  687  ASP   A CA  1 
ATOM   1085 C  C   . ASP   A 1 153 ? 19.63154 -37.73126 -23.15899 1.000 32.63730 ?  687  ASP   A C   1 
ATOM   1086 O  O   . ASP   A 1 153 ? 19.38151 -37.92131 -21.96322 1.000 31.20896 ?  687  ASP   A O   1 
ATOM   1087 C  CB  . ASP   A 1 153 ? 17.98842 -38.24265 -24.98595 1.000 39.51819 ?  687  ASP   A CB  1 
ATOM   1088 C  CG  . ASP   A 1 153 ? 16.64591 -37.85504 -25.57395 1.000 40.72499 ?  687  ASP   A CG  1 
ATOM   1089 O  OD1 . ASP   A 1 153 ? 15.86945 -37.15987 -24.88544 1.000 45.32379 ?  687  ASP   A OD1 1 
ATOM   1090 O  OD2 . ASP   A 1 153 ? 16.36481 -38.25291 -26.72463 1.000 41.20446 ?  687  ASP   A OD2 1 
ATOM   1091 N  N   . GLN   A 1 154 ? 20.81832 -38.02310 -23.69566 1.000 31.96106 ?  688  GLN   A N   1 
ATOM   1092 C  CA  . GLN   A 1 154 ? 21.94628 -38.42392 -22.86184 1.000 34.94719 ?  688  GLN   A CA  1 
ATOM   1093 C  C   . GLN   A 1 154 ? 22.23919 -37.36879 -21.80527 1.000 31.45008 ?  688  GLN   A C   1 
ATOM   1094 O  O   . GLN   A 1 154 ? 22.40477 -37.68195 -20.62036 1.000 28.67190 ?  688  GLN   A O   1 
ATOM   1095 C  CB  . GLN   A 1 154 ? 23.18134 -38.65481 -23.73438 1.000 37.50371 ?  688  GLN   A CB  1 
ATOM   1096 C  CG  . GLN   A 1 154 ? 23.06331 -39.80713 -24.71177 1.000 36.02419 ?  688  GLN   A CG  1 
ATOM   1097 C  CD  . GLN   A 1 154 ? 22.89516 -41.14129 -24.01991 1.000 43.20586 ?  688  GLN   A CD  1 
ATOM   1098 O  OE1 . GLN   A 1 154 ? 23.73654 -41.54683 -23.21752 1.000 47.72463 ?  688  GLN   A OE1 1 
ATOM   1099 N  NE2 . GLN   A 1 154 ? 21.80660 -41.83538 -24.32894 1.000 41.07371 ?  688  GLN   A NE2 1 
ATOM   1100 N  N   . CYS   A 1 155 ? 22.30943 -36.10413 -22.22808 1.000 28.74142 ?  689  CYS   A N   1 
ATOM   1101 C  CA  . CYS   A 1 155 ? 22.53749 -35.01234 -21.28856 1.000 23.05888 ?  689  CYS   A CA  1 
ATOM   1102 C  C   . CYS   A 1 155 ? 21.45417 -34.96953 -20.21942 1.000 30.15044 ?  689  CYS   A C   1 
ATOM   1103 O  O   . CYS   A 1 155 ? 21.73848 -34.69314 -19.04902 1.000 32.59078 ?  689  CYS   A O   1 
ATOM   1104 C  CB  . CYS   A 1 155 ? 22.60366 -33.68406 -22.04319 1.000 23.15347 ?  689  CYS   A CB  1 
ATOM   1105 S  SG  . CYS   A 1 155 ? 22.79705 -32.22756 -20.99434 1.000 28.37508 ?  689  CYS   A SG  1 
ATOM   1106 N  N   . LEU   A 1 156 ? 20.20701 -35.25734 -20.59846 1.000 30.15219 ?  690  LEU   A N   1 
ATOM   1107 C  CA  . LEU   A 1 156 ? 19.11701 -35.22149 -19.62865 1.000 27.73834 ?  690  LEU   A CA  1 
ATOM   1108 C  C   . LEU   A 1 156 ? 19.17136 -36.41297 -18.67926 1.000 30.25833 ?  690  LEU   A C   1 
ATOM   1109 O  O   . LEU   A 1 156 ? 18.89959 -36.26743 -17.48135 1.000 32.65655 ?  690  LEU   A O   1 
ATOM   1110 C  CB  . LEU   A 1 156 ? 17.77026 -35.17308 -20.34646 1.000 39.89461 ?  690  LEU   A CB  1 
ATOM   1111 C  CG  . LEU   A 1 156 ? 16.57314 -34.85200 -19.44771 1.000 28.69659 ?  690  LEU   A CG  1 
ATOM   1112 C  CD1 . LEU   A 1 156 ? 16.57179 -33.38712 -19.04162 1.000 29.92395 ?  690  LEU   A CD1 1 
ATOM   1113 C  CD2 . LEU   A 1 156 ? 15.26790 -35.22553 -20.12983 1.000 34.80882 ?  690  LEU   A CD2 1 
ATOM   1114 N  N   . MET   A 1 157 ? 19.50998 -37.59940 -19.19356 1.000 27.49861 ?  691  MET   A N   1 
ATOM   1115 C  CA  . MET   A 1 157 ? 19.55737 -38.78940 -18.34734 1.000 28.71993 ?  691  MET   A CA  1 
ATOM   1116 C  C   . MET   A 1 157 ? 20.56058 -38.61474 -17.21453 1.000 34.08387 ?  691  MET   A C   1 
ATOM   1117 O  O   . MET   A 1 157 ? 20.23211 -38.82137 -16.03976 1.000 40.34241 ?  691  MET   A O   1 
ATOM   1118 C  CB  . MET   A 1 157 ? 19.91126 -40.02139 -19.18172 1.000 35.60656 ?  691  MET   A CB  1 
ATOM   1119 C  CG  . MET   A 1 157 ? 20.66591 -41.07840 -18.38677 1.000 38.52338 ?  691  MET   A CG  1 
ATOM   1120 S  SD  . MET   A 1 157 ? 21.78716 -42.11442 -19.34152 1.000 63.79725 ?  691  MET   A SD  1 
ATOM   1121 C  CE  . MET   A 1 157 ? 22.38061 -43.20918 -18.05312 1.000 39.05642 ?  691  MET   A CE  1 
ATOM   1122 N  N   . ILE   A 1 158 ? 21.79188 -38.22176 -17.55251 1.000 34.83206 ?  692  ILE   A N   1 
ATOM   1123 C  CA  . ILE   A 1 158 ? 22.83332 -38.07090 -16.54041 1.000 36.68847 ?  692  ILE   A CA  1 
ATOM   1124 C  C   . ILE   A 1 158 ? 22.46572 -36.96680 -15.55831 1.000 33.09734 ?  692  ILE   A C   1 
ATOM   1125 O  O   . ILE   A 1 158 ? 22.64878 -37.11107 -14.34355 1.000 38.46573 ?  692  ILE   A O   1 
ATOM   1126 C  CB  . ILE   A 1 158 ? 24.19526 -37.80786 -17.21077 1.000 37.40481 ?  692  ILE   A CB  1 
ATOM   1127 C  CG1 . ILE   A 1 158 ? 24.56094 -38.96204 -18.14868 1.000 34.86146 ?  692  ILE   A CG1 1 
ATOM   1128 C  CG2 . ILE   A 1 158 ? 25.27966 -37.60894 -16.16300 1.000 31.20170 ?  692  ILE   A CG2 1 
ATOM   1129 C  CD1 . ILE   A 1 158 ? 25.79213 -38.70077 -18.99622 1.000 34.18150 ?  692  ILE   A CD1 1 
ATOM   1130 N  N   . LEU   A 1 159 ? 21.92501 -35.85474 -16.06508 1.000 34.84523 ?  693  LEU   A N   1 
ATOM   1131 C  CA  . LEU   A 1 159 ? 21.51329 -34.75566 -15.19823 1.000 36.03497 ?  693  LEU   A CA  1 
ATOM   1132 C  C   . LEU   A 1 159 ? 20.44494 -35.17693 -14.19783 1.000 33.56676 ?  693  LEU   A C   1 
ATOM   1133 O  O   . LEU   A 1 159 ? 20.31556 -34.54692 -13.14244 1.000 31.87600 ?  693  LEU   A O   1 
ATOM   1134 C  CB  . LEU   A 1 159 ? 21.00409 -33.58423 -16.04073 1.000 33.26151 ?  693  LEU   A CB  1 
ATOM   1135 C  CG  . LEU   A 1 159 ? 22.06212 -32.60266 -16.54774 1.000 33.19376 ?  693  LEU   A CG  1 
ATOM   1136 C  CD1 . LEU   A 1 159 ? 21.50731 -31.74485 -17.67385 1.000 31.47961 ?  693  LEU   A CD1 1 
ATOM   1137 C  CD2 . LEU   A 1 159 ? 22.56866 -31.73506 -15.41123 1.000 34.97613 ?  693  LEU   A CD2 1 
ATOM   1138 N  N   . ASN   A 1 160 ? 19.67951 -36.22370 -14.50317 1.000 33.26022 ?  694  ASN   A N   1 
ATOM   1139 C  CA  . ASN   A 1 160 ? 18.68801 -36.75654 -13.58218 1.000 33.59617 ?  694  ASN   A CA  1 
ATOM   1140 C  C   . ASN   A 1 160 ? 19.12563 -38.05538 -12.92027 1.000 36.93190 ?  694  ASN   A C   1 
ATOM   1141 O  O   . ASN   A 1 160 ? 18.43844 -38.52499 -12.00667 1.000 37.34810 ?  694  ASN   A O   1 
ATOM   1142 C  CB  . ASN   A 1 160 ? 17.35610 -36.97847 -14.30749 1.000 35.97923 ?  694  ASN   A CB  1 
ATOM   1143 C  CG  . ASN   A 1 160 ? 16.63105 -35.68155 -14.59398 1.000 39.07420 ?  694  ASN   A CG  1 
ATOM   1144 O  OD1 . ASN   A 1 160 ? 16.57782 -34.78840 -13.74758 1.000 47.08380 ?  694  ASN   A OD1 1 
ATOM   1145 N  ND2 . ASN   A 1 160 ? 16.06778 -35.56897 -15.79047 1.000 33.82729 ?  694  ASN   A ND2 1 
ATOM   1146 N  N   . SER   A 1 161 ? 20.23499 -38.64361 -13.35709 1.000 38.65400 ?  695  SER   A N   1 
ATOM   1147 C  CA  . SER   A 1 161 ? 20.74039 -39.85022 -12.71974 1.000 35.70780 ?  695  SER   A CA  1 
ATOM   1148 C  C   . SER   A 1 161 ? 21.06779 -39.55858 -11.25848 1.000 43.72389 ?  695  SER   A C   1 
ATOM   1149 O  O   . SER   A 1 161 ? 21.66961 -38.51693 -10.96043 1.000 37.18810 ?  695  SER   A O   1 
ATOM   1150 C  CB  . SER   A 1 161 ? 21.98351 -40.36268 -13.44727 1.000 33.46754 ?  695  SER   A CB  1 
ATOM   1151 O  OG  . SER   A 1 161 ? 21.63346 -41.08157 -14.61696 1.000 43.71413 ?  695  SER   A OG  1 
ATOM   1152 N  N   . PRO   A 1 162 ? 20.68511 -40.43133 -10.32649 1.000 52.06748 ?  696  PRO   A N   1 
ATOM   1153 C  CA  . PRO   A 1 162 ? 20.92744 -40.14592 -8.90673  1.000 45.41097 ?  696  PRO   A CA  1 
ATOM   1154 C  C   . PRO   A 1 162 ? 22.41380 -40.00671 -8.61181  1.000 39.31332 ?  696  PRO   A C   1 
ATOM   1155 O  O   . PRO   A 1 162 ? 23.24405 -40.76293 -9.12060  1.000 38.49145 ?  696  PRO   A O   1 
ATOM   1156 C  CB  . PRO   A 1 162 ? 20.31657 -41.35611 -8.18822  1.000 40.86892 ?  696  PRO   A CB  1 
ATOM   1157 C  CG  . PRO   A 1 162 ? 20.21404 -42.42264 -9.23097  1.000 32.03819 ?  696  PRO   A CG  1 
ATOM   1158 C  CD  . PRO   A 1 162 ? 19.99354 -41.71514 -10.52886 1.000 39.61154 ?  696  PRO   A CD  1 
ATOM   1159 N  N   . GLY   A 1 163 ? 22.74271 -39.01644 -7.78329  1.000 41.94268 ?  697  GLY   A N   1 
ATOM   1160 C  CA  . GLY   A 1 163 ? 24.11656 -38.68354 -7.48595  1.000 42.65164 ?  697  GLY   A CA  1 
ATOM   1161 C  C   . GLY   A 1 163 ? 24.76015 -37.71449 -8.45327  1.000 40.19305 ?  697  GLY   A C   1 
ATOM   1162 O  O   . GLY   A 1 163 ? 25.88103 -37.25772 -8.19259  1.000 42.62413 ?  697  GLY   A O   1 
ATOM   1163 N  N   . ASN   A 1 164 ? 24.08937 -37.38346 -9.55889  1.000 42.10692 ?  698  ASN   A N   1 
ATOM   1164 C  CA  . ASN   A 1 164 ? 24.63251 -36.49072 -10.57360 1.000 36.22921 ?  698  ASN   A CA  1 
ATOM   1165 C  C   . ASN   A 1 164 ? 23.84580 -35.19718 -10.72578 1.000 35.48011 ?  698  ASN   A C   1 
ATOM   1166 O  O   . ASN   A 1 164 ? 24.28891 -34.30607 -11.46097 1.000 38.96657 ?  698  ASN   A O   1 
ATOM   1167 C  CB  . ASN   A 1 164 ? 24.68125 -37.19841 -11.93797 1.000 32.68641 ?  698  ASN   A CB  1 
ATOM   1168 C  CG  . ASN   A 1 164 ? 25.51537 -38.46882 -11.91806 1.000 34.43485 ?  698  ASN   A CG  1 
ATOM   1169 O  OD1 . ASN   A 1 164 ? 26.66947 -38.47434 -12.34562 1.000 36.36555 ?  698  ASN   A OD1 1 
ATOM   1170 N  ND2 . ASN   A 1 164 ? 24.92663 -39.55710 -11.43668 1.000 36.63122 ?  698  ASN   A ND2 1 
ATOM   1171 N  N   . GLN   A 1 165 ? 22.70270 -35.06765 -10.05047 1.000 37.07520 ?  699  GLN   A N   1 
ATOM   1172 C  CA  . GLN   A 1 165 ? 21.76306 -33.96658 -10.27428 1.000 43.77086 ?  699  GLN   A CA  1 
ATOM   1173 C  C   . GLN   A 1 165 ? 22.38902 -32.66241 -9.78505  1.000 39.53561 ?  699  GLN   A C   1 
ATOM   1174 O  O   . GLN   A 1 165 ? 22.08628 -32.14842 -8.70446  1.000 40.06998 ?  699  GLN   A O   1 
ATOM   1175 C  CB  . GLN   A 1 165 ? 20.44135 -34.25519 -9.57169  1.000 35.55502 ?  699  GLN   A CB  1 
ATOM   1176 C  CG  . GLN   A 1 165 ? 19.72977 -35.50049 -10.07801 1.000 36.74565 ?  699  GLN   A CG  1 
ATOM   1177 C  CD  . GLN   A 1 165 ? 18.80761 -36.11214 -9.04012  1.000 41.51078 ?  699  GLN   A CD  1 
ATOM   1178 O  OE1 . GLN   A 1 165 ? 18.94651 -37.28058 -8.67879  1.000 46.28218 ?  699  GLN   A OE1 1 
ATOM   1179 N  NE2 . GLN   A 1 165 ? 17.85278 -35.32473 -8.56146  1.000 50.46826 ?  699  GLN   A NE2 1 
ATOM   1180 N  N   . ILE   A 1 166 ? 23.27893 -32.11180 -10.61748 1.000 37.07697 ?  700  ILE   A N   1 
ATOM   1181 C  CA  . ILE   A 1 166 ? 23.96871 -30.87570 -10.26683 1.000 37.09297 ?  700  ILE   A CA  1 
ATOM   1182 C  C   . ILE   A 1 166 ? 23.03366 -29.67593 -10.28059 1.000 40.69248 ?  700  ILE   A C   1 
ATOM   1183 O  O   . ILE   A 1 166 ? 23.35863 -28.63690 -9.69332  1.000 49.38329 ?  700  ILE   A O   1 
ATOM   1184 C  CB  . ILE   A 1 166 ? 25.15876 -30.62511 -11.21200 1.000 33.99594 ?  700  ILE   A CB  1 
ATOM   1185 C  CG1 . ILE   A 1 166 ? 24.73053 -30.78020 -12.67061 1.000 41.55731 ?  700  ILE   A CG1 1 
ATOM   1186 C  CG2 . ILE   A 1 166 ? 26.31348 -31.55484 -10.87709 1.000 34.09804 ?  700  ILE   A CG2 1 
ATOM   1187 C  CD1 . ILE   A 1 166 ? 25.75994 -30.28241 -13.65467 1.000 38.21094 ?  700  ILE   A CD1 1 
ATOM   1188 N  N   . LEU   A 1 167 ? 21.87948 -29.78576 -10.93230 1.000 41.51371 ?  701  LEU   A N   1 
ATOM   1189 C  CA  . LEU   A 1 167 ? 20.91402 -28.69835 -10.98547 1.000 39.42902 ?  701  LEU   A CA  1 
ATOM   1190 C  C   . LEU   A 1 167 ? 19.92911 -28.72889 -9.82482  1.000 34.27031 ?  701  LEU   A C   1 
ATOM   1191 O  O   . LEU   A 1 167 ? 18.97258 -27.94807 -9.82198  1.000 35.04093 ?  701  LEU   A O   1 
ATOM   1192 C  CB  . LEU   A 1 167 ? 20.14975 -28.73109 -12.31256 1.000 36.12491 ?  701  LEU   A CB  1 
ATOM   1193 C  CG  . LEU   A 1 167 ? 20.96772 -28.51661 -13.58857 1.000 30.58529 ?  701  LEU   A CG  1 
ATOM   1194 C  CD1 . LEU   A 1 167 ? 20.17993 -28.94760 -14.81619 1.000 24.82394 ?  701  LEU   A CD1 1 
ATOM   1195 C  CD2 . LEU   A 1 167 ? 21.40854 -27.06799 -13.71528 1.000 28.98449 ?  701  LEU   A CD2 1 
ATOM   1196 N  N   . SER   A 1 168 ? 20.14599 -29.60591 -8.84050  1.000 37.82557 ?  702  SER   A N   1 
ATOM   1197 C  CA  . SER   A 1 168 ? 19.20010 -29.74101 -7.73716  1.000 36.97234 ?  702  SER   A CA  1 
ATOM   1198 C  C   . SER   A 1 168 ? 19.08578 -28.45646 -6.92670  1.000 37.37273 ?  702  SER   A C   1 
ATOM   1199 O  O   . SER   A 1 168 ? 18.01713 -28.16296 -6.37819  1.000 46.68783 ?  702  SER   A O   1 
ATOM   1200 C  CB  . SER   A 1 168 ? 19.61349 -30.90300 -6.83448  1.000 42.43906 ?  702  SER   A CB  1 
ATOM   1201 O  OG  . SER   A 1 168 ? 20.51039 -30.46968 -5.82697  1.000 49.99143 ?  702  SER   A OG  1 
ATOM   1202 N  N   . GLY   A 1 169 ? 20.16530 -27.67884 -6.84159  1.000 42.56408 ?  703  GLY   A N   1 
ATOM   1203 C  CA  . GLY   A 1 169 ? 20.12163 -26.40751 -6.14037  1.000 40.60530 ?  703  GLY   A CA  1 
ATOM   1204 C  C   . GLY   A 1 169 ? 19.28570 -25.34388 -6.82086  1.000 36.34689 ?  703  GLY   A C   1 
ATOM   1205 O  O   . GLY   A 1 169 ? 19.07288 -24.27825 -6.23295  1.000 34.41495 ?  703  GLY   A O   1 
ATOM   1206 N  N   . LEU   A 1 170 ? 18.80954 -25.60623 -8.03323  1.000 39.74995 ?  704  LEU   A N   1 
ATOM   1207 C  CA  . LEU   A 1 170 ? 18.01760 -24.63618 -8.77068  1.000 33.80360 ?  704  LEU   A CA  1 
ATOM   1208 C  C   . LEU   A 1 170 ? 16.55050 -24.73063 -8.36928  1.000 41.02719 ?  704  LEU   A C   1 
ATOM   1209 O  O   . LEU   A 1 170 ? 16.06086 -25.79289 -7.97401  1.000 42.92109 ?  704  LEU   A O   1 
ATOM   1210 C  CB  . LEU   A 1 170 ? 18.15816 -24.86834 -10.27433 1.000 35.71026 ?  704  LEU   A CB  1 
ATOM   1211 C  CG  . LEU   A 1 170 ? 19.37466 -24.28090 -10.99054 1.000 34.58802 ?  704  LEU   A CG  1 
ATOM   1212 C  CD1 . LEU   A 1 170 ? 20.64194 -25.05073 -10.65758 1.000 36.39389 ?  704  LEU   A CD1 1 
ATOM   1213 C  CD2 . LEU   A 1 170 ? 19.12770 -24.28333 -12.48465 1.000 29.68849 ?  704  LEU   A CD2 1 
ATOM   1214 N  N   . SER   A 1 171 ? 15.84636 -23.60666 -8.47624  1.000 39.50235 ?  705  SER   A N   1 
ATOM   1215 C  CA  . SER   A 1 171 ? 14.41330 -23.58044 -8.20694  1.000 42.37657 ?  705  SER   A CA  1 
ATOM   1216 C  C   . SER   A 1 171 ? 13.69445 -24.29643 -9.34961  1.000 46.20457 ?  705  SER   A C   1 
ATOM   1217 O  O   . SER   A 1 171 ? 14.31525 -24.90440 -10.22442 1.000 47.80225 ?  705  SER   A O   1 
ATOM   1218 C  CB  . SER   A 1 171 ? 13.92624 -22.14631 -8.01633  1.000 40.13598 ?  705  SER   A CB  1 
ATOM   1219 O  OG  . SER   A 1 171 ? 13.75548 -21.48257 -9.25579  1.000 40.08641 ?  705  SER   A OG  1 
ATOM   1220 N  N   . ILE   A 1 172 ? 12.36314 -24.23341 -9.36127  1.000 43.62400 ?  706  ILE   A N   1 
ATOM   1221 C  CA  . ILE   A 1 172 ? 11.62706 -24.98087 -10.37579 1.000 42.84258 ?  706  ILE   A CA  1 
ATOM   1222 C  C   . ILE   A 1 172 ? 11.59585 -24.22560 -11.70114 1.000 41.14378 ?  706  ILE   A C   1 
ATOM   1223 O  O   . ILE   A 1 172 ? 11.77643 -24.82439 -12.76692 1.000 37.98675 ?  706  ILE   A O   1 
ATOM   1224 C  CB  . ILE   A 1 172 ? 10.21388 -25.33555 -9.87391  1.000 43.99470 ?  706  ILE   A CB  1 
ATOM   1225 C  CG1 . ILE   A 1 172 ? 9.51042  -26.25517 -10.87482 1.000 38.90050 ?  706  ILE   A CG1 1 
ATOM   1226 C  CG2 . ILE   A 1 172 ? 9.38822  -24.08955 -9.59422  1.000 43.05739 ?  706  ILE   A CG2 1 
ATOM   1227 C  CD1 . ILE   A 1 172 ? 10.30093 -27.49485 -11.22060 1.000 37.47868 ?  706  ILE   A CD1 1 
ATOM   1228 N  N   . GLU   A 1 173 ? 11.38450 -22.90807 -11.67183 1.000 44.94465 ?  707  GLU   A N   1 
ATOM   1229 C  CA  . GLU   A 1 173 ? 11.44260 -22.13430 -12.90552 1.000 45.04421 ?  707  GLU   A CA  1 
ATOM   1230 C  C   . GLU   A 1 173 ? 12.85595 -21.68768 -13.24759 1.000 43.51832 ?  707  GLU   A C   1 
ATOM   1231 O  O   . GLU   A 1 173 ? 13.10391 -21.28555 -14.38976 1.000 44.96049 ?  707  GLU   A O   1 
ATOM   1232 C  CB  . GLU   A 1 173 ? 10.50994 -20.91769 -12.83963 1.000 46.43581 ?  707  GLU   A CB  1 
ATOM   1233 C  CG  . GLU   A 1 173 ? 10.95277 -19.79387 -11.91960 1.000 50.98542 ?  707  GLU   A CG  1 
ATOM   1234 C  CD  . GLU   A 1 173 ? 10.61433 -20.06326 -10.47003 1.000 60.40959 ?  707  GLU   A CD  1 
ATOM   1235 O  OE1 . GLU   A 1 173 ? 9.88474  -21.04020 -10.20285 1.000 56.43218 ?  707  GLU   A OE1 1 
ATOM   1236 O  OE2 . GLU   A 1 173 ? 11.06907 -19.29195 -9.59951  1.000 59.35528 ?  707  GLU   A OE2 1 
ATOM   1237 N  N   . GLU   A 1 174 ? 13.77891 -21.73266 -12.28418 1.000 38.82622 ?  708  GLU   A N   1 
ATOM   1238 C  CA  . GLU   A 1 174 ? 15.19846 -21.73222 -12.62138 1.000 38.26062 ?  708  GLU   A CA  1 
ATOM   1239 C  C   . GLU   A 1 174 ? 15.54838 -22.97057 -13.43481 1.000 40.30587 ?  708  GLU   A C   1 
ATOM   1240 O  O   . GLU   A 1 174 ? 16.19047 -22.88322 -14.48824 1.000 42.46401 ?  708  GLU   A O   1 
ATOM   1241 C  CB  . GLU   A 1 174 ? 16.04353 -21.69002 -11.34790 1.000 37.05119 ?  708  GLU   A CB  1 
ATOM   1242 C  CG  . GLU   A 1 174 ? 16.58788 -20.32861 -10.96446 1.000 37.14707 ?  708  GLU   A CG  1 
ATOM   1243 C  CD  . GLU   A 1 174 ? 17.48832 -20.39987 -9.74279  1.000 50.10985 ?  708  GLU   A CD  1 
ATOM   1244 O  OE1 . GLU   A 1 174 ? 17.59990 -21.49289 -9.15034  1.000 43.19087 ?  708  GLU   A OE1 1 
ATOM   1245 O  OE2 . GLU   A 1 174 ? 18.08707 -19.36774 -9.37450  1.000 59.40468 ?  708  GLU   A OE2 1 
ATOM   1246 N  N   . TYR   A 1 175 ? 15.12016 -24.13994 -12.95143 1.000 41.70226 ?  709  TYR   A N   1 
ATOM   1247 C  CA  . TYR   A 1 175 ? 15.44085 -25.40232 -13.60957 1.000 39.70758 ?  709  TYR   A CA  1 
ATOM   1248 C  C   . TYR   A 1 175 ? 14.78318 -25.50043 -14.98006 1.000 37.46927 ?  709  TYR   A C   1 
ATOM   1249 O  O   . TYR   A 1 175 ? 15.39980 -25.98013 -15.93849 1.000 37.65309 ?  709  TYR   A O   1 
ATOM   1250 C  CB  . TYR   A 1 175 ? 15.00650 -26.56491 -12.71678 1.000 37.90843 ?  709  TYR   A CB  1 
ATOM   1251 C  CG  . TYR   A 1 175 ? 15.17906 -27.93358 -13.32446 1.000 38.87099 ?  709  TYR   A CG  1 
ATOM   1252 C  CD1 . TYR   A 1 175 ? 16.40978 -28.57383 -13.30122 1.000 34.98619 ?  709  TYR   A CD1 1 
ATOM   1253 C  CD2 . TYR   A 1 175 ? 14.10683 -28.59260 -13.91011 1.000 39.02140 ?  709  TYR   A CD2 1 
ATOM   1254 C  CE1 . TYR   A 1 175 ? 16.57102 -29.82915 -13.85106 1.000 37.80373 ?  709  TYR   A CE1 1 
ATOM   1255 C  CE2 . TYR   A 1 175 ? 14.25772 -29.84775 -14.46388 1.000 45.08692 ?  709  TYR   A CE2 1 
ATOM   1256 C  CZ  . TYR   A 1 175 ? 15.49255 -30.46189 -14.43132 1.000 45.47436 ?  709  TYR   A CZ  1 
ATOM   1257 O  OH  . TYR   A 1 175 ? 15.65224 -31.71343 -14.98011 1.000 44.61099 ?  709  TYR   A OH  1 
ATOM   1258 N  N   . LYS   A 1 176 ? 13.52611 -25.06223 -15.08967 1.000 43.28310 ?  710  LYS   A N   1 
ATOM   1259 C  CA  . LYS   A 1 176 ? 12.83984 -25.09469 -16.37756 1.000 36.68223 ?  710  LYS   A CA  1 
ATOM   1260 C  C   . LYS   A 1 176 ? 13.57619 -24.25869 -17.41616 1.000 41.97694 ?  710  LYS   A C   1 
ATOM   1261 O  O   . LYS   A 1 176 ? 13.74399 -24.68703 -18.56465 1.000 39.99453 ?  710  LYS   A O   1 
ATOM   1262 C  CB  . LYS   A 1 176 ? 11.40339 -24.59843 -16.21978 1.000 33.43958 ?  710  LYS   A CB  1 
ATOM   1263 C  CG  . LYS   A 1 176 ? 10.45543 -25.59249 -15.57188 1.000 32.68813 ?  710  LYS   A CG  1 
ATOM   1264 C  CD  . LYS   A 1 176 ? 9.00917  -25.16017 -15.75350 1.000 32.46780 ?  710  LYS   A CD  1 
ATOM   1265 C  CE  . LYS   A 1 176 ? 8.82812  -23.68282 -15.43795 1.000 46.42245 ?  710  LYS   A CE  1 
ATOM   1266 N  NZ  . LYS   A 1 176 ? 7.39103  -23.29860 -15.39205 1.000 43.17469 ?  710  LYS   A NZ  1 
ATOM   1267 N  N   . THR   A 1 177 ? 14.03050 -23.06540 -17.02660 1.000 39.23138 ?  711  THR   A N   1 
ATOM   1268 C  CA  . THR   A 1 177 ? 14.71572 -22.18453 -17.96687 1.000 37.49913 ?  711  THR   A CA  1 
ATOM   1269 C  C   . THR   A 1 177 ? 16.03722 -22.78827 -18.42492 1.000 48.17082 ?  711  THR   A C   1 
ATOM   1270 O  O   . THR   A 1 177 ? 16.31028 -22.87083 -19.62838 1.000 50.96146 ?  711  THR   A O   1 
ATOM   1271 C  CB  . THR   A 1 177 ? 14.94690 -20.81501 -17.32884 1.000 39.61420 ?  711  THR   A CB  1 
ATOM   1272 O  OG1 . THR   A 1 177 ? 13.68568 -20.18977 -17.05712 1.000 49.81756 ?  711  THR   A OG1 1 
ATOM   1273 C  CG2 . THR   A 1 177 ? 15.76274 -19.92781 -18.25275 1.000 43.18369 ?  711  THR   A CG2 1 
ATOM   1274 N  N   . THR   A 1 178 ? 16.87157 -23.21589 -17.47218 1.000 40.57798 ?  712  THR   A N   1 
ATOM   1275 C  CA  . THR   A 1 178 ? 18.16979 -23.79328 -17.81032 1.000 36.06762 ?  712  THR   A CA  1 
ATOM   1276 C  C   . THR   A 1 178 ? 18.02491 -24.97589 -18.75867 1.000 37.06989 ?  712  THR   A C   1 
ATOM   1277 O  O   . THR   A 1 178 ? 18.79920 -25.11709 -19.71235 1.000 39.61188 ?  712  THR   A O   1 
ATOM   1278 C  CB  . THR   A 1 178 ? 18.89777 -24.22158 -16.53466 1.000 30.51675 ?  712  THR   A CB  1 
ATOM   1279 O  OG1 . THR   A 1 178 ? 18.69323 -23.23490 -15.51653 1.000 36.42062 ?  712  THR   A OG1 1 
ATOM   1280 C  CG2 . THR   A 1 178 ? 20.38876 -24.37967 -16.79314 1.000 29.22970 ?  712  THR   A CG2 1 
ATOM   1281 N  N   . LEU   A 1 179 ? 17.02756 -25.82897 -18.51788 1.000 38.75575 ?  713  LEU   A N   1 
ATOM   1282 C  CA  . LEU   A 1 179 ? 16.81835 -26.99477 -19.37030 1.000 37.37406 ?  713  LEU   A CA  1 
ATOM   1283 C  C   . LEU   A 1 179 ? 16.51640 -26.57996 -20.80532 1.000 40.34591 ?  713  LEU   A C   1 
ATOM   1284 O  O   . LEU   A 1 179 ? 17.05514 -27.15637 -21.75795 1.000 32.92543 ?  713  LEU   A O   1 
ATOM   1285 C  CB  . LEU   A 1 179 ? 15.68614 -27.85256 -18.80652 1.000 35.65140 ?  713  LEU   A CB  1 
ATOM   1286 C  CG  . LEU   A 1 179 ? 15.76608 -29.35391 -19.08108 1.000 32.94797 ?  713  LEU   A CG  1 
ATOM   1287 C  CD1 . LEU   A 1 179 ? 17.21105 -29.82778 -19.06119 1.000 44.38792 ?  713  LEU   A CD1 1 
ATOM   1288 C  CD2 . LEU   A 1 179 ? 14.93049 -30.11876 -18.06979 1.000 32.88112 ?  713  LEU   A CD2 1 
ATOM   1289 N  N   . LYS   A 1 180 ? 15.65419 -25.57432 -20.97722 1.000 39.21338 ?  714  LYS   A N   1 
ATOM   1290 C  CA  . LYS   A 1 180 ? 15.31981 -25.10392 -22.31727 1.000 34.52470 ?  714  LYS   A CA  1 
ATOM   1291 C  C   . LYS   A 1 180 ? 16.54959 -24.56304 -23.03531 1.000 35.14037 ?  714  LYS   A C   1 
ATOM   1292 O  O   . LYS   A 1 180 ? 16.73363 -24.80490 -24.23342 1.000 37.52859 ?  714  LYS   A O   1 
ATOM   1293 C  CB  . LYS   A 1 180 ? 14.22860 -24.03679 -22.23772 1.000 43.00286 ?  714  LYS   A CB  1 
ATOM   1294 C  CG  . LYS   A 1 180 ? 13.42885 -23.87029 -23.51794 1.000 45.12907 ?  714  LYS   A CG  1 
ATOM   1295 C  CD  . LYS   A 1 180 ? 13.38981 -22.41816 -23.96170 1.000 41.41357 ?  714  LYS   A CD  1 
ATOM   1296 C  CE  . LYS   A 1 180 ? 14.74504 -21.95575 -24.46525 1.000 46.59732 ?  714  LYS   A CE  1 
ATOM   1297 N  NZ  . LYS   A 1 180 ? 14.77485 -20.48509 -24.68489 1.000 40.07991 ?  714  LYS   A NZ  1 
ATOM   1298 N  N   . ILE   A 1 181 ? 17.40893 -23.83740 -22.31656 1.000 35.51627 ?  715  ILE   A N   1 
ATOM   1299 C  CA  . ILE   A 1 181 ? 18.61513 -23.29208 -22.93134 1.000 33.96300 ?  715  ILE   A CA  1 
ATOM   1300 C  C   . ILE   A 1 181 ? 19.59812 -24.40761 -23.26250 1.000 34.57034 ?  715  ILE   A C   1 
ATOM   1301 O  O   . ILE   A 1 181 ? 20.24657 -24.38735 -24.31640 1.000 39.92116 ?  715  ILE   A O   1 
ATOM   1302 C  CB  . ILE   A 1 181 ? 19.25012 -22.23035 -22.01597 1.000 35.42972 ?  715  ILE   A CB  1 
ATOM   1303 C  CG1 . ILE   A 1 181 ? 18.21926 -21.17074 -21.63180 1.000 31.66433 ?  715  ILE   A CG1 1 
ATOM   1304 C  CG2 . ILE   A 1 181 ? 20.44092 -21.57739 -22.69949 1.000 34.08354 ?  715  ILE   A CG2 1 
ATOM   1305 C  CD1 . ILE   A 1 181 ? 18.66198 -20.29447 -20.48754 1.000 36.41098 ?  715  ILE   A CD1 1 
ATOM   1306 N  N   . ILE   A 1 182 ? 19.73003 -25.39294 -22.36940 1.000 34.12166 ?  716  ILE   A N   1 
ATOM   1307 C  CA  . ILE   A 1 182 ? 20.58483 -26.54488 -22.64948 1.000 33.94744 ?  716  ILE   A CA  1 
ATOM   1308 C  C   . ILE   A 1 182 ? 20.13769 -27.23183 -23.93354 1.000 36.05644 ?  716  ILE   A C   1 
ATOM   1309 O  O   . ILE   A 1 182 ? 20.95658 -27.57811 -24.79392 1.000 35.80087 ?  716  ILE   A O   1 
ATOM   1310 C  CB  . ILE   A 1 182 ? 20.58143 -27.52356 -21.46018 1.000 33.20076 ?  716  ILE   A CB  1 
ATOM   1311 C  CG1 . ILE   A 1 182 ? 21.33985 -26.93735 -20.26780 1.000 35.62207 ?  716  ILE   A CG1 1 
ATOM   1312 C  CG2 . ILE   A 1 182 ? 21.18915 -28.85862 -21.86302 1.000 30.21096 ?  716  ILE   A CG2 1 
ATOM   1313 C  CD1 . ILE   A 1 182 ? 20.86946 -27.46516 -18.92455 1.000 32.65053 ?  716  ILE   A CD1 1 
ATOM   1314 N  N   . LYS   A 1 183 ? 18.82519 -27.42406 -24.08568 1.000 35.11775 ?  717  LYS   A N   1 
ATOM   1315 C  CA  . LYS   A 1 183 ? 18.29734 -28.08324 -25.27589 1.000 35.72729 ?  717  LYS   A CA  1 
ATOM   1316 C  C   . LYS   A 1 183 ? 18.59368 -27.27330 -26.53103 1.000 37.84342 ?  717  LYS   A C   1 
ATOM   1317 O  O   . LYS   A 1 183 ? 19.05932 -27.81756 -27.53922 1.000 35.67179 ?  717  LYS   A O   1 
ATOM   1318 C  CB  . LYS   A 1 183 ? 16.79321 -28.30762 -25.12358 1.000 37.82524 ?  717  LYS   A CB  1 
ATOM   1319 C  CG  . LYS   A 1 183 ? 16.20382 -29.27524 -26.13474 1.000 35.40754 ?  717  LYS   A CG  1 
ATOM   1320 C  CD  . LYS   A 1 183 ? 14.88877 -29.84733 -25.63845 1.000 35.13002 ?  717  LYS   A CD  1 
ATOM   1321 C  CE  . LYS   A 1 183 ? 14.38170 -30.94373 -26.55804 1.000 40.43397 ?  717  LYS   A CE  1 
ATOM   1322 N  NZ  . LYS   A 1 183 ? 12.94211 -31.24084 -26.32090 1.000 35.05945 ?  717  LYS   A NZ  1 
ATOM   1323 N  N   . GLN   A 1 184 ? 18.32637 -25.96506 -26.48694 1.000 38.90817 ?  718  GLN   A N   1 
ATOM   1324 C  CA  . GLN   A 1 184 ? 18.60401 -25.11340 -27.63941 1.000 41.81499 ?  718  GLN   A CA  1 
ATOM   1325 C  C   . GLN   A 1 184 ? 20.07182 -25.18752 -28.03927 1.000 39.14285 ?  718  GLN   A C   1 
ATOM   1326 O  O   . GLN   A 1 184 ? 20.40256 -25.15147 -29.22968 1.000 42.64122 ?  718  GLN   A O   1 
ATOM   1327 C  CB  . GLN   A 1 184 ? 18.22304 -23.66351 -27.33330 1.000 45.53604 ?  718  GLN   A CB  1 
ATOM   1328 C  CG  . GLN   A 1 184 ? 16.74592 -23.40301 -27.03927 1.000 48.26170 ?  718  GLN   A CG  1 
ATOM   1329 C  CD  . GLN   A 1 184 ? 15.80051 -24.40076 -27.68602 1.000 51.85108 ?  718  GLN   A CD  1 
ATOM   1330 O  OE1 . GLN   A 1 184 ? 15.78132 -24.56118 -28.90717 1.000 44.60323 ?  718  GLN   A OE1 1 
ATOM   1331 N  NE2 . GLN   A 1 184 ? 14.99954 -25.07092 -26.86311 1.000 48.09750 ?  718  GLN   A NE2 1 
ATOM   1332 N  N   . ALA   A 1 185 ? 20.96851 -25.29335 -27.05730 1.000 39.84687 ?  719  ALA   A N   1 
ATOM   1333 C  CA  . ALA   A 1 185 ? 22.39186 -25.18740 -27.35633 1.000 30.62450 ?  719  ALA   A CA  1 
ATOM   1334 C  C   . ALA   A 1 185 ? 22.93335 -26.48126 -27.95212 1.000 32.00417 ?  719  ALA   A C   1 
ATOM   1335 O  O   . ALA   A 1 185 ? 23.72499 -26.44785 -28.90176 1.000 36.91652 ?  719  ALA   A O   1 
ATOM   1336 C  CB  . ALA   A 1 185 ? 23.16094 -24.79646 -26.09747 1.000 30.21856 ?  719  ALA   A CB  1 
ATOM   1337 N  N   . ILE   A 1 186 ? 22.52345 -27.63061 -27.41022 1.000 30.54019 ?  720  ILE   A N   1 
ATOM   1338 C  CA  . ILE   A 1 186 ? 22.94932 -28.90656 -27.97953 1.000 26.80624 ?  720  ILE   A CA  1 
ATOM   1339 C  C   . ILE   A 1 186 ? 22.42067 -29.05981 -29.40044 1.000 29.67978 ?  720  ILE   A C   1 
ATOM   1340 O  O   . ILE   A 1 186 ? 23.11659 -29.57165 -30.28605 1.000 28.60521 ?  720  ILE   A O   1 
ATOM   1341 C  CB  . ILE   A 1 186 ? 22.50169 -30.07109 -27.07790 1.000 26.59423 ?  720  ILE   A CB  1 
ATOM   1342 C  CG1 . ILE   A 1 186 ? 23.08345 -29.91112 -25.67321 1.000 26.98359 ?  720  ILE   A CG1 1 
ATOM   1343 C  CG2 . ILE   A 1 186 ? 22.92361 -31.40228 -27.67858 1.000 19.39650 ?  720  ILE   A CG2 1 
ATOM   1344 C  CD1 . ILE   A 1 186 ? 23.12277 -31.20204 -24.88313 1.000 18.98625 ?  720  ILE   A CD1 1 
ATOM   1345 N  N   . LEU   A 1 187 ? 21.18206 -28.62085 -29.64185 1.000 34.98682 ?  721  LEU   A N   1 
ATOM   1346 C  CA  . LEU   A 1 187 ? 20.64160 -28.64378 -30.99723 1.000 30.43638 ?  721  LEU   A CA  1 
ATOM   1347 C  C   . LEU   A 1 187 ? 21.35130 -27.63904 -31.89376 1.000 32.72214 ?  721  LEU   A C   1 
ATOM   1348 O  O   . LEU   A 1 187 ? 21.44332 -27.84785 -33.10896 1.000 35.92433 ?  721  LEU   A O   1 
ATOM   1349 C  CB  . LEU   A 1 187 ? 19.14007 -28.35804 -30.96993 1.000 32.89456 ?  721  LEU   A CB  1 
ATOM   1350 C  CG  . LEU   A 1 187 ? 18.27109 -29.38086 -30.23363 1.000 29.52641 ?  721  LEU   A CG  1 
ATOM   1351 C  CD1 . LEU   A 1 187 ? 16.79365 -29.02219 -30.32560 1.000 31.81857 ?  721  LEU   A CD1 1 
ATOM   1352 C  CD2 . LEU   A 1 187 ? 18.52048 -30.77764 -30.77591 1.000 24.50307 ?  721  LEU   A CD2 1 
ATOM   1353 N  N   . ALA   A 1 188 ? 21.86114 -26.54991 -31.31297 1.000 35.57379 ?  722  ALA   A N   1 
ATOM   1354 C  CA  . ALA   A 1 188 ? 22.54600 -25.53657 -32.10628 1.000 31.62571 ?  722  ALA   A CA  1 
ATOM   1355 C  C   . ALA   A 1 188 ? 23.81539 -26.08409 -32.74066 1.000 32.59404 ?  722  ALA   A C   1 
ATOM   1356 O  O   . ALA   A 1 188 ? 24.20411 -25.64478 -33.82919 1.000 37.73664 ?  722  ALA   A O   1 
ATOM   1357 C  CB  . ALA   A 1 188 ? 22.86759 -24.32375 -31.23807 1.000 28.49264 ?  722  ALA   A CB  1 
ATOM   1358 N  N   . THR   A 1 189 ? 24.47027 -27.04416 -32.08321 1.000 31.14464 ?  723  THR   A N   1 
ATOM   1359 C  CA  . THR   A 1 189 ? 25.69177 -27.63044 -32.62113 1.000 30.99769 ?  723  THR   A CA  1 
ATOM   1360 C  C   . THR   A 1 189 ? 25.46247 -28.37715 -33.92872 1.000 31.73428 ?  723  THR   A C   1 
ATOM   1361 O  O   . THR   A 1 189 ? 26.43993 -28.78225 -34.56693 1.000 32.89421 ?  723  THR   A O   1 
ATOM   1362 C  CB  . THR   A 1 189 ? 26.32254 -28.57064 -31.59152 1.000 27.64393 ?  723  THR   A CB  1 
ATOM   1363 O  OG1 . THR   A 1 189 ? 25.57150 -29.78978 -31.52853 1.000 32.84525 ?  723  THR   A OG1 1 
ATOM   1364 C  CG2 . THR   A 1 189 ? 26.34322 -27.91840 -30.21704 1.000 23.03855 ?  723  THR   A CG2 1 
ATOM   1365 N  N   . ASP   A 1 190 ? 24.21024 -28.57519 -34.33698 1.000 36.31117 ?  724  ASP   A N   1 
ATOM   1366 C  CA  . ASP   A 1 190 ? 23.91086 -29.12550 -35.65456 1.000 39.19886 ?  724  ASP   A CA  1 
ATOM   1367 C  C   . ASP   A 1 190 ? 24.35929 -28.12911 -36.71446 1.000 41.31229 ?  724  ASP   A C   1 
ATOM   1368 O  O   . ASP   A 1 190 ? 23.79167 -27.03770 -36.82936 1.000 39.63678 ?  724  ASP   A O   1 
ATOM   1369 C  CB  . ASP   A 1 190 ? 22.41927 -29.42673 -35.77622 1.000 37.45776 ?  724  ASP   A CB  1 
ATOM   1370 C  CG  . ASP   A 1 190 ? 22.05189 -30.07179 -37.10589 1.000 38.71457 ?  724  ASP   A CG  1 
ATOM   1371 O  OD1 . ASP   A 1 190 ? 22.96066 -30.51854 -37.83739 1.000 39.27704 ?  724  ASP   A OD1 1 
ATOM   1372 O  OD2 . ASP   A 1 190 ? 20.84300 -30.13205 -37.41886 1.000 42.09497 ?  724  ASP   A OD2 1 
ATOM   1373 N  N   . LEU   A 1 191 ? 25.38564 -28.49923 -37.48552 1.000 38.41333 ?  725  LEU   A N   1 
ATOM   1374 C  CA  . LEU   A 1 191 ? 25.90107 -27.60903 -38.51869 1.000 37.25761 ?  725  LEU   A CA  1 
ATOM   1375 C  C   . LEU   A 1 191 ? 24.82919 -27.21860 -39.52548 1.000 34.80248 ?  725  LEU   A C   1 
ATOM   1376 O  O   . LEU   A 1 191 ? 24.96778 -26.18762 -40.19278 1.000 33.45940 ?  725  LEU   A O   1 
ATOM   1377 C  CB  . LEU   A 1 191 ? 27.08311 -28.26459 -39.23334 1.000 35.76197 ?  725  LEU   A CB  1 
ATOM   1378 C  CG  . LEU   A 1 191 ? 28.39021 -28.33098 -38.44124 1.000 35.09581 ?  725  LEU   A CG  1 
ATOM   1379 C  CD1 . LEU   A 1 191 ? 29.27937 -29.44517 -38.96866 1.000 32.45350 ?  725  LEU   A CD1 1 
ATOM   1380 C  CD2 . LEU   A 1 191 ? 29.11256 -26.99508 -38.49114 1.000 26.08097 ?  725  LEU   A CD2 1 
ATOM   1381 N  N   . ALA   A 1 192 ? 23.76776 -28.01846 -39.64892 1.000 38.19429 ?  726  ALA   A N   1 
ATOM   1382 C  CA  . ALA   A 1 192 ? 22.63723 -27.63775 -40.48751 1.000 35.14104 ?  726  ALA   A CA  1 
ATOM   1383 C  C   . ALA   A 1 192 ? 21.93120 -26.41482 -39.91697 1.000 40.27186 ?  726  ALA   A C   1 
ATOM   1384 O  O   . ALA   A 1 192 ? 21.75046 -25.40488 -40.60771 1.000 43.70878 ?  726  ALA   A O   1 
ATOM   1385 C  CB  . ALA   A 1 192 ? 21.66513 -28.81007 -40.62439 1.000 33.35359 ?  726  ALA   A CB  1 
ATOM   1386 N  N   . LEU   A 1 193 ? 21.52572 -26.49049 -38.64433 1.000 37.94472 ?  727  LEU   A N   1 
ATOM   1387 C  CA  . LEU   A 1 193 ? 20.89299 -25.34533 -37.99671 1.000 35.47143 ?  727  LEU   A CA  1 
ATOM   1388 C  C   . LEU   A 1 193 ? 21.80860 -24.13001 -37.98379 1.000 38.80093 ?  727  LEU   A C   1 
ATOM   1389 O  O   . LEU   A 1 193 ? 21.32643 -22.99230 -38.00549 1.000 41.52668 ?  727  LEU   A O   1 
ATOM   1390 C  CB  . LEU   A 1 193 ? 20.47719 -25.70223 -36.56899 1.000 43.48064 ?  727  LEU   A CB  1 
ATOM   1391 C  CG  . LEU   A 1 193 ? 19.29339 -26.65190 -36.38475 1.000 42.40137 ?  727  LEU   A CG  1 
ATOM   1392 C  CD1 . LEU   A 1 193 ? 18.97263 -26.80279 -34.90730 1.000 33.64944 ?  727  LEU   A CD1 1 
ATOM   1393 C  CD2 . LEU   A 1 193 ? 18.07889 -26.15444 -37.15138 1.000 43.71004 ?  727  LEU   A CD2 1 
ATOM   1394 N  N   . TYR   A 1 194 ? 23.12432 -24.34642 -37.94135 1.000 42.77964 ?  728  TYR   A N   1 
ATOM   1395 C  CA  . TYR   A 1 194 ? 24.05899 -23.23095 -38.03874 1.000 45.14615 ?  728  TYR   A CA  1 
ATOM   1396 C  C   . TYR   A 1 194 ? 23.87782 -22.48116 -39.35268 1.000 40.99396 ?  728  TYR   A C   1 
ATOM   1397 O  O   . TYR   A 1 194 ? 23.77765 -21.24982 -39.37025 1.000 42.37794 ?  728  TYR   A O   1 
ATOM   1398 C  CB  . TYR   A 1 194 ? 25.49584 -23.73456 -37.90346 1.000 42.53334 ?  728  TYR   A CB  1 
ATOM   1399 C  CG  . TYR   A 1 194 ? 26.52561 -22.71428 -38.32152 1.000 39.99672 ?  728  TYR   A CG  1 
ATOM   1400 C  CD1 . TYR   A 1 194 ? 26.65128 -21.51029 -37.64290 1.000 41.83630 ?  728  TYR   A CD1 1 
ATOM   1401 C  CD2 . TYR   A 1 194 ? 27.35994 -22.94701 -39.40624 1.000 38.02288 ?  728  TYR   A CD2 1 
ATOM   1402 C  CE1 . TYR   A 1 194 ? 27.58616 -20.57012 -38.02594 1.000 39.38884 ?  728  TYR   A CE1 1 
ATOM   1403 C  CE2 . TYR   A 1 194 ? 28.29737 -22.01338 -39.79712 1.000 39.78194 ?  728  TYR   A CE2 1 
ATOM   1404 C  CZ  . TYR   A 1 194 ? 28.40586 -20.82718 -39.10340 1.000 35.69468 ?  728  TYR   A CZ  1 
ATOM   1405 O  OH  . TYR   A 1 194 ? 29.33839 -19.89483 -39.49197 1.000 35.61064 ?  728  TYR   A OH  1 
ATOM   1406 N  N   . ILE   A 1 195 ? 23.81832 -23.21445 -40.46576 1.000 40.50437 ?  729  ILE   A N   1 
ATOM   1407 C  CA  . ILE   A 1 195 ? 23.68360 -22.57948 -41.77314 1.000 40.50795 ?  729  ILE   A CA  1 
ATOM   1408 C  C   . ILE   A 1 195 ? 22.32758 -21.89273 -41.90136 1.000 45.26408 ?  729  ILE   A C   1 
ATOM   1409 O  O   . ILE   A 1 195 ? 22.22105 -20.80077 -42.47364 1.000 45.80099 ?  729  ILE   A O   1 
ATOM   1410 C  CB  . ILE   A 1 195 ? 23.91057 -23.61956 -42.88651 1.000 37.67342 ?  729  ILE   A CB  1 
ATOM   1411 C  CG1 . ILE   A 1 195 ? 25.40799 -23.88368 -43.06744 1.000 36.40572 ?  729  ILE   A CG1 1 
ATOM   1412 C  CG2 . ILE   A 1 195 ? 23.28304 -23.16383 -44.19747 1.000 38.08763 ?  729  ILE   A CG2 1 
ATOM   1413 C  CD1 . ILE   A 1 195 ? 25.74491 -25.31269 -43.46022 1.000 40.79256 ?  729  ILE   A CD1 1 
ATOM   1414 N  N   . LYS   A 1 196 ? 21.27488 -22.50832 -41.35639 1.000 41.36359 ?  730  LYS   A N   1 
ATOM   1415 C  CA  . LYS   A 1 196 ? 19.93922 -21.92883 -41.46599 1.000 42.39093 ?  730  LYS   A CA  1 
ATOM   1416 C  C   . LYS   A 1 196 ? 19.85356 -20.57554 -40.76970 1.000 42.13208 ?  730  LYS   A C   1 
ATOM   1417 O  O   . LYS   A 1 196 ? 19.26949 -19.62840 -41.31037 1.000 47.90072 ?  730  LYS   A O   1 
ATOM   1418 C  CB  . LYS   A 1 196 ? 18.89934 -22.88678 -40.88612 1.000 40.93029 ?  730  LYS   A CB  1 
ATOM   1419 C  CG  . LYS   A 1 196 ? 17.49657 -22.30177 -40.82732 1.000 48.52097 ?  730  LYS   A CG  1 
ATOM   1420 C  CD  . LYS   A 1 196 ? 16.67480 -22.90772 -39.69887 1.000 59.83118 ?  730  LYS   A CD  1 
ATOM   1421 C  CE  . LYS   A 1 196 ? 15.74891 -24.00225 -40.20546 1.000 52.46708 ?  730  LYS   A CE  1 
ATOM   1422 N  NZ  . LYS   A 1 196 ? 14.47233 -24.04043 -39.43831 1.000 46.74695 ?  730  LYS   A NZ  1 
ATOM   1423 N  N   . ARG   A 1 197 ? 20.43714 -20.46037 -39.57658 1.000 41.04802 ?  731  ARG   A N   1 
ATOM   1424 C  CA  . ARG   A 1 197 ? 20.25186 -19.28701 -38.73213 1.000 47.41763 ?  731  ARG   A CA  1 
ATOM   1425 C  C   . ARG   A 1 197 ? 21.40311 -18.28923 -38.79162 1.000 47.39433 ?  731  ARG   A C   1 
ATOM   1426 O  O   . ARG   A 1 197 ? 21.25498 -17.17484 -38.27829 1.000 46.20275 ?  731  ARG   A O   1 
ATOM   1427 C  CB  . ARG   A 1 197 ? 20.03809 -19.71863 -37.27490 1.000 40.86302 ?  731  ARG   A CB  1 
ATOM   1428 C  CG  . ARG   A 1 197 ? 18.91970 -20.73134 -37.09199 1.000 50.46575 ?  731  ARG   A CG  1 
ATOM   1429 C  CD  . ARG   A 1 197 ? 17.74310 -20.13091 -36.34296 1.000 64.71674 ?  731  ARG   A CD  1 
ATOM   1430 N  NE  . ARG   A 1 197 ? 17.88326 -20.27826 -34.89934 1.000 60.27592 ?  731  ARG   A NE  1 
ATOM   1431 C  CZ  . ARG   A 1 197 ? 17.91335 -19.26744 -34.04167 1.000 60.15100 ?  731  ARG   A CZ  1 
ATOM   1432 N  NH1 . ARG   A 1 197 ? 17.81382 -18.01216 -34.44823 1.000 57.03936 ?  731  ARG   A NH1 1 
ATOM   1433 N  NH2 . ARG   A 1 197 ? 18.04560 -19.52259 -32.74317 1.000 54.29025 ?  731  ARG   A NH2 1 
ATOM   1434 N  N   . ARG   A 1 198 ? 22.54017 -18.64881 -39.39376 1.000 43.88343 ?  732  ARG   A N   1 
ATOM   1435 C  CA  . ARG   A 1 198 ? 23.68083 -17.73759 -39.40442 1.000 45.14317 ?  732  ARG   A CA  1 
ATOM   1436 C  C   . ARG   A 1 198 ? 23.46776 -16.53995 -40.32068 1.000 49.40458 ?  732  ARG   A C   1 
ATOM   1437 O  O   . ARG   A 1 198 ? 24.11060 -15.50372 -40.11853 1.000 48.89056 ?  732  ARG   A O   1 
ATOM   1438 C  CB  . ARG   A 1 198 ? 24.95746 -18.48013 -39.80623 1.000 36.95610 ?  732  ARG   A CB  1 
ATOM   1439 C  CG  . ARG   A 1 198 ? 25.08986 -18.79404 -41.28959 1.000 35.75431 ?  732  ARG   A CG  1 
ATOM   1440 C  CD  . ARG   A 1 198 ? 26.52194 -19.19547 -41.60946 1.000 40.19994 ?  732  ARG   A CD  1 
ATOM   1441 N  NE  . ARG   A 1 198 ? 26.68633 -19.71436 -42.96165 1.000 41.46833 ?  732  ARG   A NE  1 
ATOM   1442 C  CZ  . ARG   A 1 198 ? 27.84782 -20.09720 -43.47469 1.000 39.97893 ?  732  ARG   A CZ  1 
ATOM   1443 N  NH1 . ARG   A 1 198 ? 28.96518 -20.04872 -42.76768 1.000 33.11212 ?  732  ARG   A NH1 1 
ATOM   1444 N  NH2 . ARG   A 1 198 ? 27.89051 -20.53651 -44.72891 1.000 49.60804 ?  732  ARG   A NH2 1 
ATOM   1445 N  N   . GLY   A 1 199 ? 22.58437 -16.65037 -41.31351 1.000 48.31175 ?  733  GLY   A N   1 
ATOM   1446 C  CA  . GLY   A 1 199 ? 22.29603 -15.49938 -42.15214 1.000 49.22964 ?  733  GLY   A CA  1 
ATOM   1447 C  C   . GLY   A 1 199 ? 21.69540 -14.35140 -41.36544 1.000 52.82003 ?  733  GLY   A C   1 
ATOM   1448 O  O   . GLY   A 1 199 ? 22.03586 -13.18714 -41.58760 1.000 43.70558 ?  733  GLY   A O   1 
ATOM   1449 N  N   . GLU   A 1 200 ? 20.79796 -14.66666 -40.42834 1.000 53.29630 ?  734  GLU   A N   1 
ATOM   1450 C  CA  . GLU   A 1 200 ? 20.20003 -13.63339 -39.58910 1.000 47.54610 ?  734  GLU   A CA  1 
ATOM   1451 C  C   . GLU   A 1 200 ? 21.22853 -13.02543 -38.64411 1.000 51.18685 ?  734  GLU   A C   1 
ATOM   1452 O  O   . GLU   A 1 200 ? 21.22700 -11.81013 -38.41316 1.000 52.22728 ?  734  GLU   A O   1 
ATOM   1453 C  CB  . GLU   A 1 200 ? 19.02707 -14.21512 -38.80118 1.000 43.64277 ?  734  GLU   A CB  1 
ATOM   1454 C  CG  . GLU   A 1 200 ? 18.18292 -13.17632 -38.08636 1.000 44.59432 ?  734  GLU   A CG  1 
ATOM   1455 C  CD  . GLU   A 1 200 ? 17.10106 -13.79818 -37.22770 1.000 44.09643 ?  734  GLU   A CD  1 
ATOM   1456 O  OE1 . GLU   A 1 200 ? 16.52981 -14.82984 -37.63936 1.000 42.72391 ?  734  GLU   A OE1 1 
ATOM   1457 O  OE2 . GLU   A 1 200 ? 16.82367 -13.25398 -36.13943 1.000 45.98801 ?  734  GLU   A OE2 1 
ATOM   1458 N  N   . PHE   A 1 201 ? 22.11179 -13.85601 -38.08540 1.000 54.38994 ?  735  PHE   A N   1 
ATOM   1459 C  CA  . PHE   A 1 201 ? 23.16230 -13.34240 -37.21297 1.000 54.39564 ?  735  PHE   A CA  1 
ATOM   1460 C  C   . PHE   A 1 201 ? 24.13214 -12.45528 -37.98388 1.000 51.69683 ?  735  PHE   A C   1 
ATOM   1461 O  O   . PHE   A 1 201 ? 24.58087 -11.42448 -37.47043 1.000 48.71380 ?  735  PHE   A O   1 
ATOM   1462 C  CB  . PHE   A 1 201 ? 23.90163 -14.50515 -36.55108 1.000 50.44104 ?  735  PHE   A CB  1 
ATOM   1463 C  CG  . PHE   A 1 201 ? 24.97804 -14.07899 -35.59346 1.000 47.60818 ?  735  PHE   A CG  1 
ATOM   1464 C  CD1 . PHE   A 1 201 ? 24.67297 -13.32852 -34.46822 1.000 45.16990 ?  735  PHE   A CD1 1 
ATOM   1465 C  CD2 . PHE   A 1 201 ? 26.29693 -14.43441 -35.81846 1.000 44.74940 ?  735  PHE   A CD2 1 
ATOM   1466 C  CE1 . PHE   A 1 201 ? 25.66653 -12.94205 -33.58675 1.000 46.88921 ?  735  PHE   A CE1 1 
ATOM   1467 C  CE2 . PHE   A 1 201 ? 27.29156 -14.05224 -34.94254 1.000 47.26040 ?  735  PHE   A CE2 1 
ATOM   1468 C  CZ  . PHE   A 1 201 ? 26.97695 -13.30625 -33.82489 1.000 46.93590 ?  735  PHE   A CZ  1 
ATOM   1469 N  N   . PHE   A 1 202 ? 24.46004 -12.83278 -39.22232 1.000 55.55633 ?  736  PHE   A N   1 
ATOM   1470 C  CA  . PHE   A 1 202 ? 25.37865 -12.02352 -40.01692 1.000 49.62856 ?  736  PHE   A CA  1 
ATOM   1471 C  C   . PHE   A 1 202 ? 24.69144 -10.76422 -40.52784 1.000 50.29522 ?  736  PHE   A C   1 
ATOM   1472 O  O   . PHE   A 1 202 ? 25.28313 -9.67899  -40.51559 1.000 47.40704 ?  736  PHE   A O   1 
ATOM   1473 C  CB  . PHE   A 1 202 ? 25.93305 -12.84759 -41.17769 1.000 46.62434 ?  736  PHE   A CB  1 
ATOM   1474 C  CG  . PHE   A 1 202 ? 26.78999 -14.00750 -40.74755 1.000 41.76122 ?  736  PHE   A CG  1 
ATOM   1475 C  CD1 . PHE   A 1 202 ? 27.24631 -14.11303 -39.44238 1.000 41.70067 ?  736  PHE   A CD1 1 
ATOM   1476 C  CD2 . PHE   A 1 202 ? 27.12701 -15.00152 -41.64918 1.000 40.37224 ?  736  PHE   A CD2 1 
ATOM   1477 C  CE1 . PHE   A 1 202 ? 28.02790 -15.18372 -39.05047 1.000 42.02763 ?  736  PHE   A CE1 1 
ATOM   1478 C  CE2 . PHE   A 1 202 ? 27.90825 -16.07142 -41.26335 1.000 37.42196 ?  736  PHE   A CE2 1 
ATOM   1479 C  CZ  . PHE   A 1 202 ? 28.35810 -16.16435 -39.96278 1.000 36.54036 ?  736  PHE   A CZ  1 
ATOM   1480 N  N   . GLU   A 1 203 ? 23.44008 -10.89286 -40.97857 1.000 55.32755 ?  737  GLU   A N   1 
ATOM   1481 C  CA  . GLU   A 1 203 ? 22.64735 -9.72684  -41.35865 1.000 55.09299 ?  737  GLU   A CA  1 
ATOM   1482 C  C   . GLU   A 1 203 ? 22.56114 -8.71716  -40.22185 1.000 50.08363 ?  737  GLU   A C   1 
ATOM   1483 O  O   . GLU   A 1 203 ? 22.64981 -7.50449  -40.44592 1.000 54.05827 ?  737  GLU   A O   1 
ATOM   1484 C  CB  . GLU   A 1 203 ? 21.24563 -10.17349 -41.77431 1.000 54.79188 ?  737  GLU   A CB  1 
ATOM   1485 C  CG  . GLU   A 1 203 ? 20.53538 -9.25251  -42.74682 1.000 61.51408 ?  737  GLU   A CG  1 
ATOM   1486 C  CD  . GLU   A 1 203 ? 19.04073 -9.50705  -42.78058 1.000 70.68384 ?  737  GLU   A CD  1 
ATOM   1487 O  OE1 . GLU   A 1 203 ? 18.63953 -10.68988 -42.80341 1.000 61.80213 ?  737  GLU   A OE1 1 
ATOM   1488 O  OE2 . GLU   A 1 203 ? 18.26677 -8.52716  -42.77398 1.000 71.64555 ?  737  GLU   A OE2 1 
ATOM   1489 N  N   . LEU   A 1 204 ? 22.39015 -9.20322  -38.99104 1.000 53.31199 ?  738  LEU   A N   1 
ATOM   1490 C  CA  . LEU   A 1 204 ? 22.21275 -8.30827  -37.85222 1.000 61.22695 ?  738  LEU   A CA  1 
ATOM   1491 C  C   . LEU   A 1 204 ? 23.50329 -7.56956  -37.51583 1.000 63.46049 ?  738  LEU   A C   1 
ATOM   1492 O  O   . LEU   A 1 204 ? 23.48647 -6.35523  -37.28260 1.000 65.97587 ?  738  LEU   A O   1 
ATOM   1493 C  CB  . LEU   A 1 204 ? 21.70655 -9.10276  -36.65003 1.000 63.25576 ?  738  LEU   A CB  1 
ATOM   1494 C  CG  . LEU   A 1 204 ? 20.18394 -9.19737  -36.55088 1.000 62.67693 ?  738  LEU   A CG  1 
ATOM   1495 C  CD1 . LEU   A 1 204 ? 19.78343 -10.32180 -35.61779 1.000 58.93688 ?  738  LEU   A CD1 1 
ATOM   1496 C  CD2 . LEU   A 1 204 ? 19.59314 -7.87327  -36.08873 1.000 62.03477 ?  738  LEU   A CD2 1 
ATOM   1497 N  N   . ILE   A 1 205 ? 24.63195 -8.28265  -37.48635 1.000 62.42073 ?  739  ILE   A N   1 
ATOM   1498 C  CA  . ILE   A 1 205 ? 25.91851 -7.63420  -37.26436 1.000 60.33758 ?  739  ILE   A CA  1 
ATOM   1499 C  C   . ILE   A 1 205 ? 26.30257 -6.74913  -38.44399 1.000 61.98358 ?  739  ILE   A C   1 
ATOM   1500 O  O   . ILE   A 1 205 ? 27.05393 -5.78247  -38.27234 1.000 65.38564 ?  739  ILE   A O   1 
ATOM   1501 C  CB  . ILE   A 1 205 ? 27.00217 -8.69556  -36.99020 1.000 62.56046 ?  739  ILE   A CB  1 
ATOM   1502 C  CG1 . ILE   A 1 205 ? 26.60297 -9.57407  -35.80153 1.000 60.31015 ?  739  ILE   A CG1 1 
ATOM   1503 C  CG2 . ILE   A 1 205 ? 28.35297 -8.04410  -36.72678 1.000 59.45105 ?  739  ILE   A CG2 1 
ATOM   1504 C  CD1 . ILE   A 1 205 ? 27.77476 -10.17483 -35.06089 1.000 55.34326 ?  739  ILE   A CD1 1 
ATOM   1505 N  N   . ARG   A 1 206 ? 25.77381 -7.03901  -39.63608 1.000 63.33474 ?  740  ARG   A N   1 
ATOM   1506 C  CA  . ARG   A 1 206 ? 26.17329 -6.31162  -40.83704 1.000 61.58353 ?  740  ARG   A CA  1 
ATOM   1507 C  C   . ARG   A 1 206 ? 25.84409 -4.82672  -40.75038 1.000 63.96663 ?  740  ARG   A C   1 
ATOM   1508 O  O   . ARG   A 1 206 ? 26.56890 -4.00196  -41.31746 1.000 68.96129 ?  740  ARG   A O   1 
ATOM   1509 C  CB  . ARG   A 1 206 ? 25.49528 -6.92247  -42.06467 1.000 58.92861 ?  740  ARG   A CB  1 
ATOM   1510 C  CG  . ARG   A 1 206 ? 26.45153 -7.48627  -43.10015 1.000 56.15996 ?  740  ARG   A CG  1 
ATOM   1511 C  CD  . ARG   A 1 206 ? 25.87540 -8.72868  -43.76653 1.000 52.45711 ?  740  ARG   A CD  1 
ATOM   1512 N  NE  . ARG   A 1 206 ? 24.57738 -8.47325  -44.38018 1.000 56.57747 ?  740  ARG   A NE  1 
ATOM   1513 C  CZ  . ARG   A 1 206 ? 23.75352 -9.41861  -44.81180 1.000 56.49061 ?  740  ARG   A CZ  1 
ATOM   1514 N  NH1 . ARG   A 1 206 ? 24.05947 -10.70174 -44.70941 1.000 53.74533 ?  740  ARG   A NH1 1 
ATOM   1515 N  NH2 . ARG   A 1 206 ? 22.59326 -9.06785  -45.35947 1.000 52.54581 ?  740  ARG   A NH2 1 
ATOM   1516 N  N   . LYS   A 1 207 ? 24.76821 -4.46242  -40.05433 1.000 66.24830 ?  741  LYS   A N   1 
ATOM   1517 C  CA  . LYS   A 1 207 ? 24.24508 -3.09781  -40.08748 1.000 71.12441 ?  741  LYS   A CA  1 
ATOM   1518 C  C   . LYS   A 1 207 ? 23.95846 -2.57938  -38.68063 1.000 63.93223 ?  741  LYS   A C   1 
ATOM   1519 O  O   . LYS   A 1 207 ? 22.93420 -1.94230  -38.42634 1.000 64.17843 ?  741  LYS   A O   1 
ATOM   1520 C  CB  . LYS   A 1 207 ? 22.99011 -3.03065  -40.95284 1.000 69.04437 ?  741  LYS   A CB  1 
ATOM   1521 C  CG  . LYS   A 1 207 ? 22.00478 -4.16375  -40.70378 1.000 61.76819 ?  741  LYS   A CG  1 
ATOM   1522 C  CD  . LYS   A 1 207 ? 21.14112 -4.42500  -41.92804 1.000 57.84525 ?  741  LYS   A CD  1 
ATOM   1523 C  CE  . LYS   A 1 207 ? 20.27478 -5.66002  -41.74068 1.000 61.81641 ?  741  LYS   A CE  1 
ATOM   1524 N  NZ  . LYS   A 1 207 ? 18.92210 -5.48000  -42.33406 1.000 63.81174 ?  741  LYS   A NZ  1 
ATOM   1525 N  N   . ASN   A 1 208 ? 24.87627 -2.84476  -37.74630 1.000 67.69392 ?  742  ASN   A N   1 
ATOM   1526 C  CA  . ASN   A 1 208 ? 24.81261 -2.29876  -36.38226 1.000 70.36334 ?  742  ASN   A CA  1 
ATOM   1527 C  C   . ASN   A 1 208 ? 23.45264 -2.54312  -35.72995 1.000 70.16434 ?  742  ASN   A C   1 
ATOM   1528 O  O   . ASN   A 1 208 ? 23.01055 -1.77931  -34.86686 1.000 72.05374 ?  742  ASN   A O   1 
ATOM   1529 C  CB  . ASN   A 1 208 ? 25.15524 -0.80519  -36.36256 1.000 74.36502 ?  742  ASN   A CB  1 
ATOM   1530 C  CG  . ASN   A 1 208 ? 26.60340 -0.54317  -35.99582 1.000 75.45174 ?  742  ASN   A CG  1 
ATOM   1531 O  OD1 . ASN   A 1 208 ? 27.50469 -1.27765  -36.40005 1.000 73.47561 ?  742  ASN   A OD1 1 
ATOM   1532 N  ND2 . ASN   A 1 208 ? 26.83314 0.51231   -35.22026 1.000 67.25720 ?  742  ASN   A ND2 1 
ATOM   1533 N  N   . GLN   A 1 209 ? 22.77798 -3.61340  -36.13854 1.000 71.85930 ?  743  GLN   A N   1 
ATOM   1534 C  CA  . GLN   A 1 209 ? 21.43916 -3.92401  -35.66058 1.000 74.02625 ?  743  GLN   A CA  1 
ATOM   1535 C  C   . GLN   A 1 209 ? 21.43395 -4.96834  -34.55228 1.000 71.95137 ?  743  GLN   A C   1 
ATOM   1536 O  O   . GLN   A 1 209 ? 20.35933 -5.32650  -34.06159 1.000 69.17586 ?  743  GLN   A O   1 
ATOM   1537 C  CB  . GLN   A 1 209 ? 20.56760 -4.39503  -36.83098 1.000 73.25182 ?  743  GLN   A CB  1 
ATOM   1538 C  CG  . GLN   A 1 209 ? 19.09255 -4.05311  -36.70037 1.000 76.87359 ?  743  GLN   A CG  1 
ATOM   1539 C  CD  . GLN   A 1 209 ? 18.35477 -4.15495  -38.02058 1.000 72.46534 ?  743  GLN   A CD  1 
ATOM   1540 O  OE1 . GLN   A 1 209 ? 18.03582 -5.25026  -38.48256 1.000 72.71485 ?  743  GLN   A OE1 1 
ATOM   1541 N  NE2 . GLN   A 1 209 ? 18.07778 -3.01005  -38.63492 1.000 65.21203 ?  743  GLN   A NE2 1 
ATOM   1542 N  N   . PHE   A 1 210 ? 22.60084 -5.45374  -34.13631 1.000 69.27099 ?  744  PHE   A N   1 
ATOM   1543 C  CA  . PHE   A 1 210 ? 22.64795 -6.52000  -33.14468 1.000 67.57472 ?  744  PHE   A CA  1 
ATOM   1544 C  C   . PHE   A 1 210 ? 22.32720 -5.97839  -31.75633 1.000 66.65861 ?  744  PHE   A C   1 
ATOM   1545 O  O   . PHE   A 1 210 ? 22.91595 -4.98810  -31.31093 1.000 64.97031 ?  744  PHE   A O   1 
ATOM   1546 C  CB  . PHE   A 1 210 ? 24.01896 -7.19147  -33.15108 1.000 63.13078 ?  744  PHE   A CB  1 
ATOM   1547 C  CG  . PHE   A 1 210 ? 24.06778 -8.46759  -32.36506 1.000 61.25325 ?  744  PHE   A CG  1 
ATOM   1548 C  CD1 . PHE   A 1 210 ? 23.41180 -9.60052  -32.81808 1.000 57.53923 ?  744  PHE   A CD1 1 
ATOM   1549 C  CD2 . PHE   A 1 210 ? 24.76672 -8.53479  -31.17277 1.000 56.47397 ?  744  PHE   A CD2 1 
ATOM   1550 C  CE1 . PHE   A 1 210 ? 23.45199 -10.77585 -32.09577 1.000 51.80604 ?  744  PHE   A CE1 1 
ATOM   1551 C  CE2 . PHE   A 1 210 ? 24.81207 -9.70777  -30.44721 1.000 52.82437 ?  744  PHE   A CE2 1 
ATOM   1552 C  CZ  . PHE   A 1 210 ? 24.15380 -10.82999 -30.90921 1.000 46.09376 ?  744  PHE   A CZ  1 
ATOM   1553 N  N   . ASN   A 1 211 ? 21.38891 -6.63273  -31.07278 1.000 64.78777 ?  745  ASN   A N   1 
ATOM   1554 C  CA  . ASN   A 1 211 ? 20.96589 -6.21436  -29.73800 1.000 60.64080 ?  745  ASN   A CA  1 
ATOM   1555 C  C   . ASN   A 1 211 ? 20.65052 -7.46012  -28.92488 1.000 65.72732 ?  745  ASN   A C   1 
ATOM   1556 O  O   . ASN   A 1 211 ? 19.71924 -8.19830  -29.25951 1.000 64.27466 ?  745  ASN   A O   1 
ATOM   1557 C  CB  . ASN   A 1 211 ? 19.74900 -5.28553  -29.81411 1.000 56.62328 ?  745  ASN   A CB  1 
ATOM   1558 C  CG  . ASN   A 1 211 ? 19.36264 -4.70340  -28.46286 1.000 59.99867 ?  745  ASN   A CG  1 
ATOM   1559 O  OD1 . ASN   A 1 211 ? 19.18477 -5.42815  -27.48547 1.000 59.39864 ?  745  ASN   A OD1 1 
ATOM   1560 N  ND2 . ASN   A 1 211 ? 19.23272 -3.38293  -28.40582 1.000 70.59548 ?  745  ASN   A ND2 1 
ATOM   1561 N  N   . LEU   A 1 212 ? 21.41765 -7.68758  -27.85573 1.000 66.80779 ?  746  LEU   A N   1 
ATOM   1562 C  CA  . LEU   A 1 212 ? 21.24431 -8.89973  -27.06322 1.000 62.16161 ?  746  LEU   A CA  1 
ATOM   1563 C  C   . LEU   A 1 212 ? 20.00982 -8.84456  -26.17418 1.000 64.73623 ?  746  LEU   A C   1 
ATOM   1564 O  O   . LEU   A 1 212 ? 19.50282 -9.89959  -25.77776 1.000 66.48223 ?  746  LEU   A O   1 
ATOM   1565 C  CB  . LEU   A 1 212 ? 22.48152 -9.16054  -26.20010 1.000 56.44067 ?  746  LEU   A CB  1 
ATOM   1566 C  CG  . LEU   A 1 212 ? 23.82655 -9.41570  -26.88723 1.000 51.09652 ?  746  LEU   A CG  1 
ATOM   1567 C  CD1 . LEU   A 1 212 ? 24.52774 -8.11414  -27.26151 1.000 64.70500 ?  746  LEU   A CD1 1 
ATOM   1568 C  CD2 . LEU   A 1 212 ? 24.71402 -10.26077 -25.99043 1.000 43.30843 ?  746  LEU   A CD2 1 
ATOM   1569 N  N   . GLU   A 1 213 ? 19.51826 -7.64667  -25.84747 1.000 65.76613 ?  747  GLU   A N   1 
ATOM   1570 C  CA  . GLU   A 1 213 ? 18.35024 -7.53495  -24.98060 1.000 62.84103 ?  747  GLU   A CA  1 
ATOM   1571 C  C   . GLU   A 1 213 ? 17.08270 -8.05322  -25.64891 1.000 58.82171 ?  747  GLU   A C   1 
ATOM   1572 O  O   . GLU   A 1 213 ? 16.11415 -8.37168  -24.95028 1.000 54.80617 ?  747  GLU   A O   1 
ATOM   1573 C  CB  . GLU   A 1 213 ? 18.17002 -6.08389  -24.53408 1.000 58.71384 ?  747  GLU   A CB  1 
ATOM   1574 C  CG  . GLU   A 1 213 ? 19.48499 -5.39730  -24.18881 1.000 65.87672 ?  747  GLU   A CG  1 
ATOM   1575 C  CD  . GLU   A 1 213 ? 19.42317 -4.63531  -22.88227 1.000 70.54448 ?  747  GLU   A CD  1 
ATOM   1576 O  OE1 . GLU   A 1 213 ? 19.02447 -5.23734  -21.86324 1.000 68.50743 ?  747  GLU   A OE1 1 
ATOM   1577 O  OE2 . GLU   A 1 213 ? 19.77521 -3.43639  -22.87401 1.000 77.20538 ?  747  GLU   A OE2 1 
ATOM   1578 N  N   . ASP   A 1 214 ? 17.06691 -8.14186  -26.97218 1.000 59.24877 ?  748  ASP   A N   1 
ATOM   1579 C  CA  . ASP   A 1 214 ? 15.99962 -8.84495  -27.67362 1.000 54.57987 ?  748  ASP   A CA  1 
ATOM   1580 C  C   . ASP   A 1 214 ? 16.12098 -10.33002 -27.36023 1.000 59.81853 ?  748  ASP   A C   1 
ATOM   1581 O  O   . ASP   A 1 214 ? 17.16729 -10.92607 -27.64826 1.000 64.05673 ?  748  ASP   A O   1 
ATOM   1582 C  CB  . ASP   A 1 214 ? 16.10044 -8.59538  -29.17963 1.000 50.64358 ?  748  ASP   A CB  1 
ATOM   1583 C  CG  . ASP   A 1 214 ? 15.08717 -9.39733  -29.98697 1.000 58.93064 ?  748  ASP   A CG  1 
ATOM   1584 O  OD1 . ASP   A 1 214 ? 14.10800 -9.90820  -29.40475 1.000 57.95098 ?  748  ASP   A OD1 1 
ATOM   1585 O  OD2 . ASP   A 1 214 ? 15.27152 -9.51308  -31.21750 1.000 63.89139 ?  748  ASP   A OD2 1 
ATOM   1586 N  N   . PRO   A 1 215 ? 15.10514 -10.96056 -26.76183 1.000 56.59557 ?  749  PRO   A N   1 
ATOM   1587 C  CA  . PRO   A 1 215 ? 15.23521 -12.38707 -26.41557 1.000 52.87253 ?  749  PRO   A CA  1 
ATOM   1588 C  C   . PRO   A 1 215 ? 15.53666 -13.28006 -27.60638 1.000 53.22092 ?  749  PRO   A C   1 
ATOM   1589 O  O   . PRO   A 1 215 ? 16.21335 -14.30379 -27.44444 1.000 54.79447 ?  749  PRO   A O   1 
ATOM   1590 C  CB  . PRO   A 1 215 ? 13.87167 -12.71932 -25.79355 1.000 55.38756 ?  749  PRO   A CB  1 
ATOM   1591 C  CG  . PRO   A 1 215 ? 13.36441 -11.41460 -25.28180 1.000 56.24355 ?  749  PRO   A CG  1 
ATOM   1592 C  CD  . PRO   A 1 215 ? 13.84942 -10.37903 -26.25547 1.000 59.30645 ?  749  PRO   A CD  1 
ATOM   1593 N  N   . HIS   A 1 216 ? 15.05933 -12.92403 -28.80064 1.000 57.50788 ?  750  HIS   A N   1 
ATOM   1594 C  CA  . HIS   A 1 216 ? 15.33323 -13.74123 -29.97839 1.000 56.30140 ?  750  HIS   A CA  1 
ATOM   1595 C  C   . HIS   A 1 216 ? 16.79961 -13.65177 -30.38153 1.000 54.33811 ?  750  HIS   A C   1 
ATOM   1596 O  O   . HIS   A 1 216 ? 17.45214 -14.67512 -30.61642 1.000 53.35303 ?  750  HIS   A O   1 
ATOM   1597 C  CB  . HIS   A 1 216 ? 14.43321 -13.31445 -31.13670 1.000 59.19420 ?  750  HIS   A CB  1 
ATOM   1598 C  CG  . HIS   A 1 216 ? 14.75034 -14.00062 -32.42845 1.000 60.02605 ?  750  HIS   A CG  1 
ATOM   1599 N  ND1 . HIS   A 1 216 ? 14.32694 -15.28049 -32.71513 1.000 61.10522 ?  750  HIS   A ND1 1 
ATOM   1600 C  CD2 . HIS   A 1 216 ? 15.45665 -13.58756 -33.50713 1.000 56.75274 ?  750  HIS   A CD2 1 
ATOM   1601 C  CE1 . HIS   A 1 216 ? 14.75512 -15.62462 -33.91667 1.000 61.30666 ?  750  HIS   A CE1 1 
ATOM   1602 N  NE2 . HIS   A 1 216 ? 15.44333 -14.61516 -34.41872 1.000 56.91994 ?  750  HIS   A NE2 1 
ATOM   1603 N  N   . GLN   A 1 217 ? 17.33268 -12.43024 -30.47551 1.000 53.21681 ?  751  GLN   A N   1 
ATOM   1604 C  CA  . GLN   A 1 217 ? 18.73659 -12.25645 -30.83432 1.000 55.07653 ?  751  GLN   A CA  1 
ATOM   1605 C  C   . GLN   A 1 217 ? 19.65833 -12.90872 -29.81394 1.000 55.52068 ?  751  GLN   A C   1 
ATOM   1606 O  O   . GLN   A 1 217 ? 20.76175 -13.34709 -30.16100 1.000 49.53508 ?  751  GLN   A O   1 
ATOM   1607 C  CB  . GLN   A 1 217 ? 19.06296 -10.77032 -30.96261 1.000 54.27206 ?  751  GLN   A CB  1 
ATOM   1608 C  CG  . GLN   A 1 217 ? 18.57318 -10.12970 -32.24753 1.000 52.77931 ?  751  GLN   A CG  1 
ATOM   1609 C  CD  . GLN   A 1 217 ? 19.00972 -8.68412  -32.37528 1.000 63.30201 ?  751  GLN   A CD  1 
ATOM   1610 O  OE1 . GLN   A 1 217 ? 20.18680 -8.39905  -32.58469 1.000 62.46070 ?  751  GLN   A OE1 1 
ATOM   1611 N  NE2 . GLN   A 1 217 ? 18.05994 -7.76257  -32.25171 1.000 66.77809 ?  751  GLN   A NE2 1 
ATOM   1612 N  N   . LYS   A 1 218 ? 19.22621 -12.97860 -28.55388 1.000 54.13577 ?  752  LYS   A N   1 
ATOM   1613 C  CA  . LYS   A 1 218 ? 20.04034 -13.61349 -27.52460 1.000 46.79278 ?  752  LYS   A CA  1 
ATOM   1614 C  C   . LYS   A 1 218 ? 20.14839 -15.11459 -27.76209 1.000 44.88611 ?  752  LYS   A C   1 
ATOM   1615 O  O   . LYS   A 1 218 ? 21.24935 -15.67657 -27.74080 1.000 43.12324 ?  752  LYS   A O   1 
ATOM   1616 C  CB  . LYS   A 1 218 ? 19.45748 -13.32179 -26.14265 1.000 53.33064 ?  752  LYS   A CB  1 
ATOM   1617 C  CG  . LYS   A 1 218 ? 19.99535 -14.22067 -25.04272 1.000 48.99561 ?  752  LYS   A CG  1 
ATOM   1618 C  CD  . LYS   A 1 218 ? 21.44770 -13.90421 -24.72480 1.000 41.85909 ?  752  LYS   A CD  1 
ATOM   1619 C  CE  . LYS   A 1 218 ? 21.56754 -12.61967 -23.92543 1.000 42.58127 ?  752  LYS   A CE  1 
ATOM   1620 N  NZ  . LYS   A 1 218 ? 20.99699 -12.76430 -22.55812 1.000 47.17556 ?  752  LYS   A NZ  1 
ATOM   1621 N  N   . GLU   A 1 219 ? 19.01373 -15.78267 -27.99409 1.000 45.28552 ?  753  GLU   A N   1 
ATOM   1622 C  CA  . GLU   A 1 219 ? 19.05067 -17.21564 -28.27327 1.000 48.52012 ?  753  GLU   A CA  1 
ATOM   1623 C  C   . GLU   A 1 219 ? 19.82994 -17.50609 -29.54899 1.000 52.25958 ?  753  GLU   A C   1 
ATOM   1624 O  O   . GLU   A 1 219 ? 20.60322 -18.46974 -29.60766 1.000 53.05964 ?  753  GLU   A O   1 
ATOM   1625 C  CB  . GLU   A 1 219 ? 17.63362 -17.77916 -28.37753 1.000 46.97432 ?  753  GLU   A CB  1 
ATOM   1626 C  CG  . GLU   A 1 219 ? 17.59652 -19.22319 -28.86346 1.000 55.99672 ?  753  GLU   A CG  1 
ATOM   1627 C  CD  . GLU   A 1 219 ? 16.19593 -19.79465 -28.92060 1.000 61.59550 ?  753  GLU   A CD  1 
ATOM   1628 O  OE1 . GLU   A 1 219 ? 15.54199 -19.87852 -27.85983 1.000 66.48508 ?  753  GLU   A OE1 1 
ATOM   1629 O  OE2 . GLU   A 1 219 ? 15.75140 -20.16413 -30.02815 1.000 56.29158 ?  753  GLU   A OE2 1 
ATOM   1630 N  N   . LEU   A 1 220 ? 19.63662 -16.68347 -30.58299 1.000 49.32438 ?  754  LEU   A N   1 
ATOM   1631 C  CA  . LEU   A 1 220 ? 20.42221 -16.83142 -31.80324 1.000 51.72839 ?  754  LEU   A CA  1 
ATOM   1632 C  C   . LEU   A 1 220 ? 21.91325 -16.71010 -31.51305 1.000 48.59200 ?  754  LEU   A C   1 
ATOM   1633 O  O   . LEU   A 1 220 ? 22.72384 -17.47021 -32.05671 1.000 46.14399 ?  754  LEU   A O   1 
ATOM   1634 C  CB  . LEU   A 1 220 ? 19.98667 -15.78972 -32.83250 1.000 50.18867 ?  754  LEU   A CB  1 
ATOM   1635 C  CG  . LEU   A 1 220 ? 20.91891 -15.59277 -34.02811 1.000 43.25784 ?  754  LEU   A CG  1 
ATOM   1636 C  CD1 . LEU   A 1 220 ? 20.96794 -16.84306 -34.89765 1.000 42.97395 ?  754  LEU   A CD1 1 
ATOM   1637 C  CD2 . LEU   A 1 220 ? 20.49425 -14.37990 -34.83613 1.000 42.17457 ?  754  LEU   A CD2 1 
ATOM   1638 N  N   . PHE   A 1 221 ? 22.29237 -15.76523 -30.64790 1.000 47.05577 ?  755  PHE   A N   1 
ATOM   1639 C  CA  . PHE   A 1 221 ? 23.69893 -15.61045 -30.29171 1.000 41.31145 ?  755  PHE   A CA  1 
ATOM   1640 C  C   . PHE   A 1 221 ? 24.22092 -16.83594 -29.55231 1.000 46.60325 ?  755  PHE   A C   1 
ATOM   1641 O  O   . PHE   A 1 221 ? 25.33893 -17.29663 -29.81310 1.000 46.41430 ?  755  PHE   A O   1 
ATOM   1642 C  CB  . PHE   A 1 221 ? 23.89420 -14.35486 -29.44374 1.000 39.72184 ?  755  PHE   A CB  1 
ATOM   1643 C  CG  . PHE   A 1 221 ? 25.27498 -14.22553 -28.87236 1.000 36.21330 ?  755  PHE   A CG  1 
ATOM   1644 C  CD1 . PHE   A 1 221 ? 26.37473 -14.08909 -29.70455 1.000 37.85299 ?  755  PHE   A CD1 1 
ATOM   1645 C  CD2 . PHE   A 1 221 ? 25.47601 -14.25906 -27.50394 1.000 41.27441 ?  755  PHE   A CD2 1 
ATOM   1646 C  CE1 . PHE   A 1 221 ? 27.64978 -13.97676 -29.17897 1.000 36.11475 ?  755  PHE   A CE1 1 
ATOM   1647 C  CE2 . PHE   A 1 221 ? 26.74583 -14.14824 -26.97236 1.000 40.94704 ?  755  PHE   A CE2 1 
ATOM   1648 C  CZ  . PHE   A 1 221 ? 27.83447 -14.00688 -27.81003 1.000 40.92676 ?  755  PHE   A CZ  1 
ATOM   1649 N  N   . LEU   A 1 222 ? 23.42716 -17.37473 -28.62146 1.000 46.99483 ?  756  LEU   A N   1 
ATOM   1650 C  CA  . LEU   A 1 222 ? 23.83866 -18.57643 -27.90146 1.000 42.90955 ?  756  LEU   A CA  1 
ATOM   1651 C  C   . LEU   A 1 222 ? 24.05236 -19.74129 -28.85897 1.000 44.19319 ?  756  LEU   A C   1 
ATOM   1652 O  O   . LEU   A 1 222 ? 24.94792 -20.56971 -28.65404 1.000 46.67292 ?  756  LEU   A O   1 
ATOM   1653 C  CB  . LEU   A 1 222 ? 22.79582 -18.93842 -26.84318 1.000 38.47163 ?  756  LEU   A CB  1 
ATOM   1654 C  CG  . LEU   A 1 222 ? 22.55020 -17.91437 -25.73292 1.000 39.02089 ?  756  LEU   A CG  1 
ATOM   1655 C  CD1 . LEU   A 1 222 ? 21.34922 -18.30884 -24.88343 1.000 45.80919 ?  756  LEU   A CD1 1 
ATOM   1656 C  CD2 . LEU   A 1 222 ? 23.78628 -17.74668 -24.87215 1.000 38.99886 ?  756  LEU   A CD2 1 
ATOM   1657 N  N   . ALA   A 1 223 ? 23.23610 -19.81871 -29.91281 1.000 43.28201 ?  757  ALA   A N   1 
ATOM   1658 C  CA  . ALA   A 1 223 ? 23.42635 -20.84710 -30.92890 1.000 37.46983 ?  757  ALA   A CA  1 
ATOM   1659 C  C   . ALA   A 1 223 ? 24.73613 -20.64353 -31.67774 1.000 38.45837 ?  757  ALA   A C   1 
ATOM   1660 O  O   . ALA   A 1 223 ? 25.44957 -21.61085 -31.97010 1.000 34.28603 ?  757  ALA   A O   1 
ATOM   1661 C  CB  . ALA   A 1 223 ? 22.24611 -20.84773 -31.90026 1.000 41.76936 ?  757  ALA   A CB  1 
ATOM   1662 N  N   . MET   A 1 224 ? 25.06896 -19.39019 -31.99233 1.000 39.47206 ?  758  MET   A N   1 
ATOM   1663 C  CA  . MET   A 1 224 ? 26.32235 -19.10634 -32.68152 1.000 40.27552 ?  758  MET   A CA  1 
ATOM   1664 C  C   . MET   A 1 224 ? 27.51909 -19.38598 -31.78313 1.000 38.84023 ?  758  MET   A C   1 
ATOM   1665 O  O   . MET   A 1 224 ? 28.53579 -19.92020 -32.24213 1.000 32.08454 ?  758  MET   A O   1 
ATOM   1666 C  CB  . MET   A 1 224 ? 26.34256 -17.65330 -33.15448 1.000 40.46141 ?  758  MET   A CB  1 
ATOM   1667 C  CG  . MET   A 1 224 ? 25.22796 -17.29128 -34.12085 1.000 41.83639 ?  758  MET   A CG  1 
ATOM   1668 S  SD  . MET   A 1 224 ? 25.30520 -18.20852 -35.67133 1.000 35.71898 ?  758  MET   A SD  1 
ATOM   1669 C  CE  . MET   A 1 224 ? 23.86196 -19.25802 -35.51647 1.000 38.37939 ?  758  MET   A CE  1 
ATOM   1670 N  N   . LEU   A 1 225 ? 27.41431 -19.02975 -30.49960 1.000 41.95757 ?  759  LEU   A N   1 
ATOM   1671 C  CA  . LEU   A 1 225 ? 28.52720 -19.22638 -29.57673 1.000 31.15726 ?  759  LEU   A CA  1 
ATOM   1672 C  C   . LEU   A 1 225 ? 28.83052 -20.70729 -29.38714 1.000 35.30437 ?  759  LEU   A C   1 
ATOM   1673 O  O   . LEU   A 1 225 ? 29.99730 -21.09739 -29.26651 1.000 38.70355 ?  759  LEU   A O   1 
ATOM   1674 C  CB  . LEU   A 1 225 ? 28.21393 -18.55587 -28.23932 1.000 35.61752 ?  759  LEU   A CB  1 
ATOM   1675 C  CG  . LEU   A 1 225 ? 29.30219 -18.51128 -27.16739 1.000 40.76001 ?  759  LEU   A CG  1 
ATOM   1676 C  CD1 . LEU   A 1 225 ? 30.47837 -17.65840 -27.61026 1.000 31.13662 ?  759  LEU   A CD1 1 
ATOM   1677 C  CD2 . LEU   A 1 225 ? 28.71104 -17.98025 -25.87592 1.000 30.78129 ?  759  LEU   A CD2 1 
ATOM   1678 N  N   . MET   A 1 226 ? 27.79270 -21.54787 -29.36878 1.000 33.83617 ?  760  MET   A N   1 
ATOM   1679 C  CA  . MET   A 1 226 ? 28.00078 -22.99088 -29.29295 1.000 27.09939 ?  760  MET   A CA  1 
ATOM   1680 C  C   . MET   A 1 226 ? 28.76364 -23.49502 -30.51012 1.000 29.15638 ?  760  MET   A C   1 
ATOM   1681 O  O   . MET   A 1 226 ? 29.74263 -24.24095 -30.38261 1.000 28.58819 ?  760  MET   A O   1 
ATOM   1682 C  CB  . MET   A 1 226 ? 26.65558 -23.70698 -29.17427 1.000 30.86093 ?  760  MET   A CB  1 
ATOM   1683 C  CG  . MET   A 1 226 ? 26.06518 -23.70243 -27.77749 1.000 26.24627 ?  760  MET   A CG  1 
ATOM   1684 S  SD  . MET   A 1 226 ? 27.10432 -24.52298 -26.55423 1.000 25.62417 ?  760  MET   A SD  1 
ATOM   1685 C  CE  . MET   A 1 226 ? 26.78181 -26.23942 -26.94369 1.000 25.24428 ?  760  MET   A CE  1 
ATOM   1686 N  N   . THR   A 1 227 ? 28.32157 -23.09578 -31.70498 1.000 35.96564 ?  761  THR   A N   1 
ATOM   1687 C  CA  . THR   A 1 227 ? 28.99834 -23.51395 -32.92693 1.000 33.71758 ?  761  THR   A CA  1 
ATOM   1688 C  C   . THR   A 1 227 ? 30.43470 -23.00725 -32.95607 1.000 35.41313 ?  761  THR   A C   1 
ATOM   1689 O  O   . THR   A 1 227 ? 31.33475 -23.69399 -33.45542 1.000 30.61607 ?  761  THR   A O   1 
ATOM   1690 C  CB  . THR   A 1 227 ? 28.21510 -23.01854 -34.14513 1.000 36.76694 ?  761  THR   A CB  1 
ATOM   1691 O  OG1 . THR   A 1 227 ? 26.93887 -23.67020 -34.18647 1.000 42.57971 ?  761  THR   A OG1 1 
ATOM   1692 C  CG2 . THR   A 1 227 ? 28.96831 -23.31559 -35.43514 1.000 31.20915 ?  761  THR   A CG2 1 
ATOM   1693 N  N   . ALA   A 1 228 ? 30.67294 -21.81687 -32.39742 1.000 36.95077 ?  762  ALA   A N   1 
ATOM   1694 C  CA  . ALA   A 1 228 ? 32.02075 -21.25735 -32.39335 1.000 32.04498 ?  762  ALA   A CA  1 
ATOM   1695 C  C   . ALA   A 1 228 ? 32.95966 -22.08371 -31.52442 1.000 33.44110 ?  762  ALA   A C   1 
ATOM   1696 O  O   . ALA   A 1 228 ? 34.14079 -22.24300 -31.85385 1.000 36.69690 ?  762  ALA   A O   1 
ATOM   1697 C  CB  . ALA   A 1 228 ? 31.98384 -19.80223 -31.92195 1.000 31.31221 ?  762  ALA   A CB  1 
ATOM   1698 N  N   . CYS   A 1 229 ? 32.45317 -22.61269 -30.40850 1.000 27.85076 ?  763  CYS   A N   1 
ATOM   1699 C  CA  . CYS   A 1 229 ? 33.25476 -23.47882 -29.55209 1.000 31.15933 ?  763  CYS   A CA  1 
ATOM   1700 C  C   . CYS   A 1 229 ? 33.29386 -24.91296 -30.06602 1.000 33.83857 ?  763  CYS   A C   1 
ATOM   1701 O  O   . CYS   A 1 229 ? 34.28201 -25.62159 -29.83990 1.000 31.66367 ?  763  CYS   A O   1 
ATOM   1702 C  CB  . CYS   A 1 229 ? 32.70789 -23.44834 -28.12354 1.000 33.01233 ?  763  CYS   A CB  1 
ATOM   1703 S  SG  . CYS   A 1 229 ? 32.55410 -21.78816 -27.42199 1.000 38.68328 ?  763  CYS   A SG  1 
ATOM   1704 N  N   . ASP   A 1 230 ? 32.23474 -25.35141 -30.75229 1.000 34.96035 ?  764  ASP   A N   1 
ATOM   1705 C  CA  . ASP   A 1 230 ? 32.18891 -26.71291 -31.27689 1.000 28.14580 ?  764  ASP   A CA  1 
ATOM   1706 C  C   . ASP   A 1 230 ? 33.32581 -26.96780 -32.25805 1.000 25.90917 ?  764  ASP   A C   1 
ATOM   1707 O  O   . ASP   A 1 230 ? 33.95441 -28.03220 -32.23061 1.000 24.55734 ?  764  ASP   A O   1 
ATOM   1708 C  CB  . ASP   A 1 230 ? 30.83681 -26.96235 -31.94609 1.000 25.33816 ?  764  ASP   A CB  1 
ATOM   1709 C  CG  . ASP   A 1 230 ? 30.50314 -28.43563 -32.06316 1.000 28.51981 ?  764  ASP   A CG  1 
ATOM   1710 O  OD1 . ASP   A 1 230 ? 31.26115 -29.26580 -31.52045 1.000 30.60482 ?  764  ASP   A OD1 1 
ATOM   1711 O  OD2 . ASP   A 1 230 ? 29.47638 -28.76292 -32.69544 1.000 33.62331 ?  764  ASP   A OD2 1 
ATOM   1712 N  N   . LEU   A 1 231 ? 33.60935 -25.99963 -33.12794 1.000 27.02956 ?  765  LEU   A N   1 
ATOM   1713 C  CA  . LEU   A 1 231 ? 34.63917 -26.13292 -34.14804 1.000 28.80033 ?  765  LEU   A CA  1 
ATOM   1714 C  C   . LEU   A 1 231 ? 35.90665 -25.36200 -33.80057 1.000 30.45117 ?  765  LEU   A C   1 
ATOM   1715 O  O   . LEU   A 1 231 ? 36.73731 -25.12062 -34.68205 1.000 34.97132 ?  765  LEU   A O   1 
ATOM   1716 C  CB  . LEU   A 1 231 ? 34.09867 -25.66523 -35.50084 1.000 26.32714 ?  765  LEU   A CB  1 
ATOM   1717 C  CG  . LEU   A 1 231 ? 32.62814 -25.97767 -35.78494 1.000 25.62449 ?  765  LEU   A CG  1 
ATOM   1718 C  CD1 . LEU   A 1 231 ? 32.07303 -25.05318 -36.85627 1.000 25.24807 ?  765  LEU   A CD1 1 
ATOM   1719 C  CD2 . LEU   A 1 231 ? 32.45023 -27.43371 -36.18876 1.000 26.35993 ?  765  LEU   A CD2 1 
ATOM   1720 N  N   . SER   A 1 232 ? 36.07389 -24.97792 -32.53360 1.000 26.33670 ?  766  SER   A N   1 
ATOM   1721 C  CA  . SER   A 1 232 ? 37.16849 -24.09918 -32.13721 1.000 24.47191 ?  766  SER   A CA  1 
ATOM   1722 C  C   . SER   A 1 232 ? 38.54363 -24.72491 -32.33077 1.000 27.91364 ?  766  SER   A C   1 
ATOM   1723 O  O   . SER   A 1 232 ? 39.54870 -24.01510 -32.20641 1.000 28.67802 ?  766  SER   A O   1 
ATOM   1724 C  CB  . SER   A 1 232 ? 36.99633 -23.68573 -30.67687 1.000 30.89551 ?  766  SER   A CB  1 
ATOM   1725 O  OG  . SER   A 1 232 ? 36.98942 -24.81883 -29.82742 1.000 32.44953 ?  766  SER   A OG  1 
ATOM   1726 N  N   . ALA   A 1 233 ? 38.61695 -26.02515 -32.62591 1.000 26.10498 ?  767  ALA   A N   1 
ATOM   1727 C  CA  . ALA   A 1 233 ? 39.90872 -26.65409 -32.87513 1.000 26.43116 ?  767  ALA   A CA  1 
ATOM   1728 C  C   . ALA   A 1 233 ? 40.58752 -26.07227 -34.10829 1.000 30.72387 ?  767  ALA   A C   1 
ATOM   1729 O  O   . ALA   A 1 233 ? 41.82027 -26.08957 -34.20343 1.000 32.08017 ?  767  ALA   A O   1 
ATOM   1730 C  CB  . ALA   A 1 233 ? 39.73335 -28.16462 -33.02504 1.000 25.29849 ?  767  ALA   A CB  1 
ATOM   1731 N  N   . ILE   A 1 234 ? 39.80413 -25.54975 -35.05695 1.000 33.24001 ?  768  ILE   A N   1 
ATOM   1732 C  CA  . ILE   A 1 234 ? 40.36877 -24.97345 -36.27186 1.000 32.34710 ?  768  ILE   A CA  1 
ATOM   1733 C  C   . ILE   A 1 234 ? 41.10418 -23.66933 -35.99020 1.000 36.32375 ?  768  ILE   A C   1 
ATOM   1734 O  O   . ILE   A 1 234 ? 41.96001 -23.26026 -36.78301 1.000 38.58232 ?  768  ILE   A O   1 
ATOM   1735 C  CB  . ILE   A 1 234 ? 39.26194 -24.76808 -37.32708 1.000 32.46807 ?  768  ILE   A CB  1 
ATOM   1736 C  CG1 . ILE   A 1 234 ? 39.86829 -24.57684 -38.71810 1.000 30.94087 ?  768  ILE   A CG1 1 
ATOM   1737 C  CG2 . ILE   A 1 234 ? 38.38853 -23.57732 -36.97209 1.000 28.67748 ?  768  ILE   A CG2 1 
ATOM   1738 C  CD1 . ILE   A 1 234 ? 40.31655 -25.85888 -39.37674 1.000 31.36390 ?  768  ILE   A CD1 1 
ATOM   1739 N  N   . THR   A 1 235 ? 40.80500 -23.01125 -34.87315 1.000 35.48923 ?  769  THR   A N   1 
ATOM   1740 C  CA  . THR   A 1 235 ? 41.44251 -21.75749 -34.49734 1.000 36.83203 ?  769  THR   A CA  1 
ATOM   1741 C  C   . THR   A 1 235 ? 42.67868 -21.95938 -33.63098 1.000 28.76738 ?  769  THR   A C   1 
ATOM   1742 O  O   . THR   A 1 235 ? 43.21981 -20.98077 -33.10474 1.000 33.25767 ?  769  THR   A O   1 
ATOM   1743 C  CB  . THR   A 1 235 ? 40.44398 -20.86567 -33.75674 1.000 37.01690 ?  769  THR   A CB  1 
ATOM   1744 O  OG1 . THR   A 1 235 ? 40.23525 -21.38157 -32.43670 1.000 33.61225 ?  769  THR   A OG1 1 
ATOM   1745 C  CG2 . THR   A 1 235 ? 39.11878 -20.84681 -34.48772 1.000 28.93906 ?  769  THR   A CG2 1 
ATOM   1746 N  N   . LYS   A 1 236 ? 43.13381 -23.19635 -33.47337 1.000 31.70480 ?  770  LYS   A N   1 
ATOM   1747 C  CA  . LYS   A 1 236 ? 44.20750 -23.51682 -32.54927 1.000 32.60515 ?  770  LYS   A CA  1 
ATOM   1748 C  C   . LYS   A 1 236 ? 45.56898 -23.20363 -33.15860 1.000 30.54908 ?  770  LYS   A C   1 
ATOM   1749 O  O   . LYS   A 1 236 ? 45.68237 -22.98952 -34.36828 1.000 33.62240 ?  770  LYS   A O   1 
ATOM   1750 C  CB  . LYS   A 1 236 ? 44.14199 -24.99147 -32.16967 1.000 33.92648 ?  770  LYS   A CB  1 
ATOM   1751 C  CG  . LYS   A 1 236 ? 43.01814 -25.32501 -31.21102 1.000 33.57211 ?  770  LYS   A CG  1 
ATOM   1752 C  CD  . LYS   A 1 236 ? 43.19167 -24.60704 -29.88370 1.000 25.18516 ?  770  LYS   A CD  1 
ATOM   1753 C  CE  . LYS   A 1 236 ? 41.91015 -24.66031 -29.06629 1.000 31.03396 ?  770  LYS   A CE  1 
ATOM   1754 N  NZ  . LYS   A 1 236 ? 42.16428 -25.00947 -27.64135 1.000 34.88979 ?  770  LYS   A NZ  1 
ATOM   1755 N  N   . PRO   A 1 237 ? 46.61668 -23.14662 -32.33572 1.000 32.63484 ?  771  PRO   A N   1 
ATOM   1756 C  CA  . PRO   A 1 237 ? 47.97375 -23.09631 -32.88557 1.000 28.32120 ?  771  PRO   A CA  1 
ATOM   1757 C  C   . PRO   A 1 237 ? 48.21415 -24.26908 -33.82673 1.000 33.82261 ?  771  PRO   A C   1 
ATOM   1758 O  O   . PRO   A 1 237 ? 47.79677 -25.39722 -33.55830 1.000 35.45378 ?  771  PRO   A O   1 
ATOM   1759 C  CB  . PRO   A 1 237 ? 48.85976 -23.16971 -31.63777 1.000 23.58229 ?  771  PRO   A CB  1 
ATOM   1760 C  CG  . PRO   A 1 237 ? 48.02790 -22.54572 -30.57185 1.000 26.92256 ?  771  PRO   A CG  1 
ATOM   1761 C  CD  . PRO   A 1 237 ? 46.60812 -22.94517 -30.87351 1.000 28.84781 ?  771  PRO   A CD  1 
ATOM   1762 N  N   . TRP   A 1 238 ? 48.88960 -23.98159 -34.94033 1.000 35.57065 ?  772  TRP   A N   1 
ATOM   1763 C  CA  . TRP   A 1 238 ? 48.98354 -24.91538 -36.06308 1.000 38.85142 ?  772  TRP   A CA  1 
ATOM   1764 C  C   . TRP   A 1 238 ? 49.36477 -26.33577 -35.66500 1.000 41.19505 ?  772  TRP   A C   1 
ATOM   1765 O  O   . TRP   A 1 238 ? 48.71557 -27.27774 -36.14904 1.000 39.65941 ?  772  TRP   A O   1 
ATOM   1766 C  CB  . TRP   A 1 238 ? 49.96305 -24.36987 -37.11002 1.000 42.22916 ?  772  TRP   A CB  1 
ATOM   1767 C  CG  . TRP   A 1 238 ? 50.41707 -25.41374 -38.08469 1.000 49.64586 ?  772  TRP   A CG  1 
ATOM   1768 C  CD1 . TRP   A 1 238 ? 51.64533 -26.00652 -38.13819 1.000 47.19927 ?  772  TRP   A CD1 1 
ATOM   1769 C  CD2 . TRP   A 1 238 ? 49.64007 -26.00564 -39.13298 1.000 47.51429 ?  772  TRP   A CD2 1 
ATOM   1770 N  NE1 . TRP   A 1 238 ? 51.68462 -26.92244 -39.16208 1.000 50.48573 ?  772  TRP   A NE1 1 
ATOM   1771 C  CE2 . TRP   A 1 238 ? 50.46535 -26.94123 -39.78742 1.000 47.49421 ?  772  TRP   A CE2 1 
ATOM   1772 C  CE3 . TRP   A 1 238 ? 48.32875 -25.83158 -39.58408 1.000 42.36497 ?  772  TRP   A CE3 1 
ATOM   1773 C  CZ2 . TRP   A 1 238 ? 50.02170 -27.69967 -40.86916 1.000 47.32859 ?  772  TRP   A CZ2 1 
ATOM   1774 C  CZ3 . TRP   A 1 238 ? 47.88965 -26.58511 -40.65831 1.000 43.30647 ?  772  TRP   A CZ3 1 
ATOM   1775 C  CH2 . TRP   A 1 238 ? 48.73353 -27.50751 -41.28837 1.000 43.81711 ?  772  TRP   A CH2 1 
ATOM   1776 N  N   . PRO   A 1 239 ? 50.37785 -26.57238 -34.82326 1.000 39.90096 ?  773  PRO   A N   1 
ATOM   1777 C  CA  . PRO   A 1 239 ? 50.69447 -27.96319 -34.45628 1.000 37.62224 ?  773  PRO   A CA  1 
ATOM   1778 C  C   . PRO   A 1 239 ? 49.56668 -28.67444 -33.73202 1.000 40.20460 ?  773  PRO   A C   1 
ATOM   1779 O  O   . PRO   A 1 239 ? 49.42005 -29.89298 -33.88470 1.000 39.56824 ?  773  PRO   A O   1 
ATOM   1780 C  CB  . PRO   A 1 239 ? 51.93486 -27.81456 -33.56343 1.000 38.96845 ?  773  PRO   A CB  1 
ATOM   1781 C  CG  . PRO   A 1 239 ? 52.52130 -26.49705 -33.95027 1.000 40.53697 ?  773  PRO   A CG  1 
ATOM   1782 C  CD  . PRO   A 1 239 ? 51.34634 -25.63011 -34.23772 1.000 41.52754 ?  773  PRO   A CD  1 
ATOM   1783 N  N   . ILE   A 1 240 ? 48.76318 -27.95693 -32.94776 1.000 36.67850 ?  774  ILE   A N   1 
ATOM   1784 C  CA  . ILE   A 1 240 ? 47.63690 -28.58954 -32.26922 1.000 35.99173 ?  774  ILE   A CA  1 
ATOM   1785 C  C   . ILE   A 1 240 ? 46.48613 -28.81501 -33.24005 1.000 34.04731 ?  774  ILE   A C   1 
ATOM   1786 O  O   . ILE   A 1 240 ? 45.91493 -29.90923 -33.30543 1.000 34.09920 ?  774  ILE   A O   1 
ATOM   1787 C  CB  . ILE   A 1 240 ? 47.19682 -27.74830 -31.05711 1.000 34.99708 ?  774  ILE   A CB  1 
ATOM   1788 C  CG1 . ILE   A 1 240 ? 48.41026 -27.34211 -30.21679 1.000 29.46860 ?  774  ILE   A CG1 1 
ATOM   1789 C  CG2 . ILE   A 1 240 ? 46.19505 -28.52090 -30.21741 1.000 31.55796 ?  774  ILE   A CG2 1 
ATOM   1790 C  CD1 . ILE   A 1 240 ? 49.25048 -28.51215 -29.75016 1.000 36.58086 ?  774  ILE   A CD1 1 
ATOM   1791 N  N   . GLN   A 1 241 ? 46.13679 -27.78496 -34.01541 1.000 36.40153 ?  775  GLN   A N   1 
ATOM   1792 C  CA  . GLN   A 1 241 ? 45.07050 -27.92401 -35.00180 1.000 38.28739 ?  775  GLN   A CA  1 
ATOM   1793 C  C   . GLN   A 1 241 ? 45.41106 -28.98084 -36.04443 1.000 35.53657 ?  775  GLN   A C   1 
ATOM   1794 O  O   . GLN   A 1 241 ? 44.51414 -29.66236 -36.55435 1.000 38.80362 ?  775  GLN   A O   1 
ATOM   1795 C  CB  . GLN   A 1 241 ? 44.79977 -26.57054 -35.66466 1.000 36.03620 ?  775  GLN   A CB  1 
ATOM   1796 C  CG  . GLN   A 1 241 ? 43.73087 -26.57666 -36.75590 1.000 37.56107 ?  775  GLN   A CG  1 
ATOM   1797 C  CD  . GLN   A 1 241 ? 44.28426 -26.92425 -38.12625 1.000 39.27211 ?  775  GLN   A CD  1 
ATOM   1798 O  OE1 . GLN   A 1 241 ? 43.70925 -27.73322 -38.85408 1.000 45.37614 ?  775  GLN   A OE1 1 
ATOM   1799 N  NE2 . GLN   A 1 241 ? 45.40978 -26.31855 -38.48019 1.000 43.46053 ?  775  GLN   A NE2 1 
ATOM   1800 N  N   . GLN   A 1 242 ? 46.69592 -29.13184 -36.37317 1.000 37.72155 ?  776  GLN   A N   1 
ATOM   1801 C  CA  . GLN   A 1 242 ? 47.10587 -30.19086 -37.28935 1.000 39.50045 ?  776  GLN   A CA  1 
ATOM   1802 C  C   . GLN   A 1 242 ? 46.88243 -31.56631 -36.67402 1.000 40.96185 ?  776  GLN   A C   1 
ATOM   1803 O  O   . GLN   A 1 242 ? 46.41066 -32.48761 -37.35111 1.000 40.16245 ?  776  GLN   A O   1 
ATOM   1804 C  CB  . GLN   A 1 242 ? 48.57311 -30.00734 -37.67677 1.000 40.74878 ?  776  GLN   A CB  1 
ATOM   1805 C  CG  . GLN   A 1 242 ? 49.22143 -31.23601 -38.28867 1.000 39.97532 ?  776  GLN   A CG  1 
ATOM   1806 C  CD  . GLN   A 1 242 ? 50.29822 -30.88354 -39.29541 1.000 55.62270 ?  776  GLN   A CD  1 
ATOM   1807 O  OE1 . GLN   A 1 242 ? 50.15092 -31.13184 -40.49247 1.000 56.75828 ?  776  GLN   A OE1 1 
ATOM   1808 N  NE2 . GLN   A 1 242 ? 51.39065 -30.30229 -38.81370 1.000 53.13218 ?  776  GLN   A NE2 1 
ATOM   1809 N  N   . ARG   A 1 243 ? 47.21242 -31.72330 -35.38949 1.000 37.28358 ?  777  ARG   A N   1 
ATOM   1810 C  CA  . ARG   A 1 243 ? 47.00411 -33.00506 -34.72653 1.000 32.71212 ?  777  ARG   A CA  1 
ATOM   1811 C  C   . ARG   A 1 243 ? 45.52233 -33.30102 -34.53173 1.000 35.54755 ?  777  ARG   A C   1 
ATOM   1812 O  O   . ARG   A 1 243 ? 45.11271 -34.46508 -34.60473 1.000 33.59180 ?  777  ARG   A O   1 
ATOM   1813 C  CB  . ARG   A 1 243 ? 47.73737 -33.02781 -33.38589 1.000 37.00012 ?  777  ARG   A CB  1 
ATOM   1814 C  CG  . ARG   A 1 243 ? 49.25786 -32.99759 -33.50644 1.000 35.65442 ?  777  ARG   A CG  1 
ATOM   1815 C  CD  . ARG   A 1 243 ? 49.83311 -34.36495 -33.83376 1.000 38.84734 ?  777  ARG   A CD  1 
ATOM   1816 N  NE  . ARG   A 1 243 ? 51.29067 -34.36108 -33.79839 1.000 47.29871 ?  777  ARG   A NE  1 
ATOM   1817 C  CZ  . ARG   A 1 243 ? 52.05732 -35.28450 -34.36170 1.000 43.58970 ?  777  ARG   A CZ  1 
ATOM   1818 N  NH1 . ARG   A 1 243 ? 51.53707 -36.31113 -35.01460 1.000 42.98524 ?  777  ARG   A NH1 1 
ATOM   1819 N  NH2 . ARG   A 1 243 ? 53.37918 -35.17571 -34.26645 1.000 37.31783 ?  777  ARG   A NH2 1 
ATOM   1820 N  N   . ILE   A 1 244 ? 44.70709 -32.27226 -34.28663 1.000 37.27956 ?  778  ILE   A N   1 
ATOM   1821 C  CA  . ILE   A 1 244 ? 43.26303 -32.47712 -34.20087 1.000 30.14599 ?  778  ILE   A CA  1 
ATOM   1822 C  C   . ILE   A 1 244 ? 42.70459 -32.87615 -35.55908 1.000 34.71966 ?  778  ILE   A C   1 
ATOM   1823 O  O   . ILE   A 1 244 ? 41.88819 -33.79918 -35.66699 1.000 41.85372 ?  778  ILE   A O   1 
ATOM   1824 C  CB  . ILE   A 1 244 ? 42.55818 -31.21874 -33.66139 1.000 33.85064 ?  778  ILE   A CB  1 
ATOM   1825 C  CG1 . ILE   A 1 244 ? 43.08610 -30.84775 -32.27875 1.000 35.40299 ?  778  ILE   A CG1 1 
ATOM   1826 C  CG2 . ILE   A 1 244 ? 41.06157 -31.45312 -33.57979 1.000 28.07564 ?  778  ILE   A CG2 1 
ATOM   1827 C  CD1 . ILE   A 1 244 ? 43.00589 -31.98325 -31.29324 1.000 35.88553 ?  778  ILE   A CD1 1 
ATOM   1828 N  N   . ALA   A 1 245 ? 43.12750 -32.17409 -36.61458 1.000 32.97593 ?  779  ALA   A N   1 
ATOM   1829 C  CA  . ALA   A 1 245 ? 42.70733 -32.52854 -37.96565 1.000 33.18730 ?  779  ALA   A CA  1 
ATOM   1830 C  C   . ALA   A 1 245 ? 43.12152 -33.94868 -38.31921 1.000 37.68826 ?  779  ALA   A C   1 
ATOM   1831 O  O   . ALA   A 1 245 ? 42.45131 -34.61238 -39.11869 1.000 46.93094 ?  779  ALA   A O   1 
ATOM   1832 C  CB  . ALA   A 1 245 ? 43.28928 -31.53732 -38.97276 1.000 32.27251 ?  779  ALA   A CB  1 
ATOM   1833 N  N   . GLU   A 1 246 ? 44.22348 -34.42674 -37.73862 1.000 36.02690 ?  780  GLU   A N   1 
ATOM   1834 C  CA  . GLU   A 1 246 ? 44.59388 -35.82975 -37.88077 1.000 37.99608 ?  780  GLU   A CA  1 
ATOM   1835 C  C   . GLU   A 1 246 ? 43.59341 -36.72857 -37.16479 1.000 38.65676 ?  780  GLU   A C   1 
ATOM   1836 O  O   . GLU   A 1 246 ? 43.16428 -37.75349 -37.70789 1.000 43.37827 ?  780  GLU   A O   1 
ATOM   1837 C  CB  . GLU   A 1 246 ? 46.00550 -36.05264 -37.33855 1.000 43.08722 ?  780  GLU   A CB  1 
ATOM   1838 C  CG  . GLU   A 1 246 ? 46.76713 -37.17881 -38.01338 1.000 48.65701 ?  780  GLU   A CG  1 
ATOM   1839 C  CD  . GLU   A 1 246 ? 48.02318 -37.56644 -37.25698 1.000 54.07780 ?  780  GLU   A CD  1 
ATOM   1840 O  OE1 . GLU   A 1 246 ? 48.77595 -36.65862 -36.84241 1.000 44.59897 ?  780  GLU   A OE1 1 
ATOM   1841 O  OE2 . GLU   A 1 246 ? 48.25898 -38.78008 -37.08038 1.000 55.08978 ?  780  GLU   A OE2 1 
ATOM   1842 N  N   . LEU   A 1 247 ? 43.21676 -36.36014 -35.93547 1.000 38.14433 ?  781  LEU   A N   1 
ATOM   1843 C  CA  . LEU   A 1 247 ? 42.18928 -37.10495 -35.21295 1.000 36.67007 ?  781  LEU   A CA  1 
ATOM   1844 C  C   . LEU   A 1 247 ? 40.88757 -37.14640 -36.00181 1.000 39.85700 ?  781  LEU   A C   1 
ATOM   1845 O  O   . LEU   A 1 247 ? 40.16581 -38.15062 -35.97576 1.000 41.26564 ?  781  LEU   A O   1 
ATOM   1846 C  CB  . LEU   A 1 247 ? 41.95462 -36.47587 -33.83902 1.000 35.70566 ?  781  LEU   A CB  1 
ATOM   1847 C  CG  . LEU   A 1 247 ? 42.85712 -36.88610 -32.67537 1.000 31.98400 ?  781  LEU   A CG  1 
ATOM   1848 C  CD1 . LEU   A 1 247 ? 42.83972 -35.80711 -31.60708 1.000 27.16251 ?  781  LEU   A CD1 1 
ATOM   1849 C  CD2 . LEU   A 1 247 ? 42.41963 -38.21993 -32.09397 1.000 38.42450 ?  781  LEU   A CD2 1 
ATOM   1850 N  N   . VAL   A 1 248 ? 40.57565 -36.06198 -36.71395 1.000 37.10182 ?  782  VAL   A N   1 
ATOM   1851 C  CA  . VAL   A 1 248 ? 39.35040 -36.00959 -37.50358 1.000 39.62593 ?  782  VAL   A CA  1 
ATOM   1852 C  C   . VAL   A 1 248 ? 39.42406 -36.98559 -38.67132 1.000 44.17265 ?  782  VAL   A C   1 
ATOM   1853 O  O   . VAL   A 1 248 ? 38.45721 -37.70016 -38.96452 1.000 45.60534 ?  782  VAL   A O   1 
ATOM   1854 C  CB  . VAL   A 1 248 ? 39.09471 -34.56739 -37.97929 1.000 37.08275 ?  782  VAL   A CB  1 
ATOM   1855 C  CG1 . VAL   A 1 248 ? 38.13158 -34.54888 -39.15336 1.000 40.93307 ?  782  VAL   A CG1 1 
ATOM   1856 C  CG2 . VAL   A 1 248 ? 38.56388 -33.71870 -36.83551 1.000 26.44673 ?  782  VAL   A CG2 1 
ATOM   1857 N  N   . ALA   A 1 249 ? 40.57419 -37.04138 -39.34694 1.000 42.90530 ?  783  ALA   A N   1 
ATOM   1858 C  CA  . ALA   A 1 249 ? 40.71962 -37.92450 -40.49944 1.000 44.28121 ?  783  ALA   A CA  1 
ATOM   1859 C  C   . ALA   A 1 249 ? 40.65408 -39.39181 -40.09162 1.000 44.43791 ?  783  ALA   A C   1 
ATOM   1860 O  O   . ALA   A 1 249 ? 40.13963 -40.22660 -40.84527 1.000 49.10594 ?  783  ALA   A O   1 
ATOM   1861 C  CB  . ALA   A 1 249 ? 42.03163 -37.62566 -41.22303 1.000 38.70912 ?  783  ALA   A CB  1 
ATOM   1862 N  N   . THR   A 1 250 ? 41.17130 -39.72554 -38.90518 1.000 41.20057 ?  784  THR   A N   1 
ATOM   1863 C  CA  . THR   A 1 250 ? 41.12683 -41.10878 -38.43796 1.000 40.54549 ?  784  THR   A CA  1 
ATOM   1864 C  C   . THR   A 1 250 ? 39.69050 -41.60138 -38.31587 1.000 45.95971 ?  784  THR   A C   1 
ATOM   1865 O  O   . THR   A 1 250 ? 39.39985 -42.77129 -38.58930 1.000 51.60264 ?  784  THR   A O   1 
ATOM   1866 C  CB  . THR   A 1 250 ? 41.84991 -41.23592 -37.09646 1.000 41.89436 ?  784  THR   A CB  1 
ATOM   1867 O  OG1 . THR   A 1 250 ? 42.90285 -40.26748 -37.02499 1.000 48.86380 ?  784  THR   A OG1 1 
ATOM   1868 C  CG2 . THR   A 1 250 ? 42.43856 -42.63126 -36.93379 1.000 36.01312 ?  784  THR   A CG2 1 
ATOM   1869 N  N   . GLU   A 1 251 ? 38.77682 -40.72018 -37.90677 1.000 44.11617 ?  785  GLU   A N   1 
ATOM   1870 C  CA  . GLU   A 1 251 ? 37.36697 -41.08905 -37.85114 1.000 41.55032 ?  785  GLU   A CA  1 
ATOM   1871 C  C   . GLU   A 1 251 ? 36.77405 -41.23483 -39.24592 1.000 49.64708 ?  785  GLU   A C   1 
ATOM   1872 O  O   . GLU   A 1 251 ? 35.97096 -42.14189 -39.49249 1.000 55.74548 ?  785  GLU   A O   1 
ATOM   1873 C  CB  . GLU   A 1 251 ? 36.58138 -40.04455 -37.06058 1.000 41.67809 ?  785  GLU   A CB  1 
ATOM   1874 C  CG  . GLU   A 1 251 ? 35.42360 -40.60389 -36.25239 1.000 44.88906 ?  785  GLU   A CG  1 
ATOM   1875 C  CD  . GLU   A 1 251 ? 34.76431 -39.55201 -35.38117 1.000 40.67539 ?  785  GLU   A CD  1 
ATOM   1876 O  OE1 . GLU   A 1 251 ? 35.39297 -39.11450 -34.39533 1.000 37.36801 ?  785  GLU   A OE1 1 
ATOM   1877 O  OE2 . GLU   A 1 251 ? 33.62010 -39.15572 -35.68704 1.000 37.18120 ?  785  GLU   A OE2 1 
ATOM   1878 N  N   . PHE   A 1 252 ? 37.16670 -40.35903 -40.17395 1.000 52.96616 ?  786  PHE   A N   1 
ATOM   1879 C  CA  . PHE   A 1 252 ? 36.39664 -40.19291 -41.40290 1.000 51.47124 ?  786  PHE   A CA  1 
ATOM   1880 C  C   . PHE   A 1 252 ? 36.58089 -41.36364 -42.36322 1.000 58.40093 ?  786  PHE   A C   1 
ATOM   1881 O  O   . PHE   A 1 252 ? 35.60415 -41.83201 -42.95987 1.000 67.90080 ?  786  PHE   A O   1 
ATOM   1882 C  CB  . PHE   A 1 252 ? 36.76076 -38.86953 -42.07369 1.000 49.60014 ?  786  PHE   A CB  1 
ATOM   1883 C  CG  . PHE   A 1 252 ? 35.76233 -37.77646 -41.81763 1.000 57.01766 ?  786  PHE   A CG  1 
ATOM   1884 C  CD1 . PHE   A 1 252 ? 34.48732 -37.84807 -42.35334 1.000 58.97540 ?  786  PHE   A CD1 1 
ATOM   1885 C  CD2 . PHE   A 1 252 ? 36.08927 -36.69017 -41.02425 1.000 61.14922 ?  786  PHE   A CD2 1 
ATOM   1886 C  CE1 . PHE   A 1 252 ? 33.56231 -36.85039 -42.11407 1.000 58.88220 ?  786  PHE   A CE1 1 
ATOM   1887 C  CE2 . PHE   A 1 252 ? 35.16740 -35.68841 -40.78041 1.000 61.27731 ?  786  PHE   A CE2 1 
ATOM   1888 C  CZ  . PHE   A 1 252 ? 33.90286 -35.76929 -41.32616 1.000 60.85637 ?  786  PHE   A CZ  1 
ATOM   1889 N  N   . PHE   A 1 253 ? 37.81022 -41.84981 -42.54341 1.000 61.95645 ?  787  PHE   A N   1 
ATOM   1890 C  CA  . PHE   A 1 253 ? 38.00796 -42.99308 -43.42785 1.000 69.28842 ?  787  PHE   A CA  1 
ATOM   1891 C  C   . PHE   A 1 253 ? 38.52835 -44.24556 -42.73500 1.000 68.07515 ?  787  PHE   A C   1 
ATOM   1892 O  O   . PHE   A 1 253 ? 38.20138 -45.34730 -43.18050 1.000 74.54786 ?  787  PHE   A O   1 
ATOM   1893 C  CB  . PHE   A 1 253 ? 38.94344 -42.63899 -44.60179 1.000 73.23140 ?  787  PHE   A CB  1 
ATOM   1894 C  CG  . PHE   A 1 253 ? 40.24764 -42.01273 -44.19562 1.000 72.54181 ?  787  PHE   A CG  1 
ATOM   1895 C  CD1 . PHE   A 1 253 ? 40.39632 -40.63549 -44.18347 1.000 60.51749 ?  787  PHE   A CD1 1 
ATOM   1896 C  CD2 . PHE   A 1 253 ? 41.33699 -42.80236 -43.86515 1.000 75.38928 ?  787  PHE   A CD2 1 
ATOM   1897 C  CE1 . PHE   A 1 253 ? 41.60031 -40.05761 -43.82626 1.000 65.03345 ?  787  PHE   A CE1 1 
ATOM   1898 C  CE2 . PHE   A 1 253 ? 42.54283 -42.23166 -43.50591 1.000 72.70734 ?  787  PHE   A CE2 1 
ATOM   1899 C  CZ  . PHE   A 1 253 ? 42.67521 -40.85743 -43.48664 1.000 70.22956 ?  787  PHE   A CZ  1 
ATOM   1900 N  N   . ASP   A 1 254 ? 39.31342 -44.12185 -41.66271 1.000 61.64950 ?  788  ASP   A N   1 
ATOM   1901 C  CA  . ASP   A 1 254 ? 39.78420 -45.31201 -40.96254 1.000 70.72085 ?  788  ASP   A CA  1 
ATOM   1902 C  C   . ASP   A 1 254 ? 38.71725 -45.93975 -40.07476 1.000 71.58194 ?  788  ASP   A C   1 
ATOM   1903 O  O   . ASP   A 1 254 ? 38.92042 -47.06287 -39.59901 1.000 78.27863 ?  788  ASP   A O   1 
ATOM   1904 C  CB  . ASP   A 1 254 ? 41.02494 -44.99006 -40.12307 1.000 74.34320 ?  788  ASP   A CB  1 
ATOM   1905 C  CG  . ASP   A 1 254 ? 42.31719 -45.33195 -40.83939 1.000 83.73070 ?  788  ASP   A CG  1 
ATOM   1906 O  OD1 . ASP   A 1 254 ? 42.38242 -45.12796 -42.06938 1.000 85.88173 ?  788  ASP   A OD1 1 
ATOM   1907 O  OD2 . ASP   A 1 254 ? 43.26522 -45.80418 -40.17763 1.000 86.36426 ?  788  ASP   A OD2 1 
ATOM   1908 N  N   . GLN   A 1 255 ? 37.60132 -45.24877 -39.84828 1.000 63.41986 ?  789  GLN   A N   1 
ATOM   1909 C  CA  . GLN   A 1 255 ? 36.47053 -45.77381 -39.08282 1.000 61.09811 ?  789  GLN   A CA  1 
ATOM   1910 C  C   . GLN   A 1 255 ? 36.87882 -46.27131 -37.69783 1.000 60.53769 ?  789  GLN   A C   1 
ATOM   1911 O  O   . GLN   A 1 255 ? 37.69855 -45.65023 -37.02133 1.000 53.73689 ?  789  GLN   A O   1 
ATOM   1912 C  CB  . GLN   A 1 255 ? 35.78021 -46.89795 -39.86155 1.000 65.56192 ?  789  GLN   A CB  1 
ATOM   1913 C  CG  . GLN   A 1 255 ? 35.16656 -46.44737 -41.17912 1.000 67.05329 ?  789  GLN   A CG  1 
ATOM   1914 C  CD  . GLN   A 1 255 ? 35.47087 -47.39286 -42.32410 1.000 68.17222 ?  789  GLN   A CD  1 
ATOM   1915 O  OE1 . GLN   A 1 255 ? 35.71424 -46.96272 -43.45167 1.000 59.67371 ?  789  GLN   A OE1 1 
ATOM   1916 N  NE2 . GLN   A 1 255 ? 35.45749 -48.68996 -42.04006 1.000 69.56139 ?  789  GLN   A NE2 1 
ATOM   1917 N  N   . LYS   A 1 278 ? 44.69583 -32.97398 -50.61801 1.000 41.77378 ?  812  LYS   A N   1 
ATOM   1918 C  CA  . LYS   A 1 278 ? 43.33441 -33.46380 -50.44389 1.000 41.91655 ?  812  LYS   A CA  1 
ATOM   1919 C  C   . LYS   A 1 278 ? 42.77905 -32.94011 -49.12549 1.000 42.17776 ?  812  LYS   A C   1 
ATOM   1920 O  O   . LYS   A 1 278 ? 41.88074 -32.10019 -49.11123 1.000 45.79188 ?  812  LYS   A O   1 
ATOM   1921 C  CB  . LYS   A 1 278 ? 43.27735 -34.99723 -50.47549 1.000 44.37582 ?  812  LYS   A CB  1 
ATOM   1922 C  CG  . LYS   A 1 278 ? 44.55733 -35.72070 -50.04756 1.000 48.34682 ?  812  LYS   A CG  1 
ATOM   1923 C  CD  . LYS   A 1 278 ? 45.57026 -35.88161 -51.17741 1.000 46.44019 ?  812  LYS   A CD  1 
ATOM   1924 C  CE  . LYS   A 1 278 ? 46.96185 -35.48728 -50.70821 1.000 41.56999 ?  812  LYS   A CE  1 
ATOM   1925 N  NZ  . LYS   A 1 278 ? 47.22667 -35.96844 -49.32303 1.000 44.21800 ?  812  LYS   A NZ  1 
ATOM   1926 N  N   . ILE   A 1 279 ? 43.32500 -33.45075 -48.01839 1.000 39.86436 ?  813  ILE   A N   1 
ATOM   1927 C  CA  . ILE   A 1 279 ? 42.98525 -32.90582 -46.70245 1.000 34.76149 ?  813  ILE   A CA  1 
ATOM   1928 C  C   . ILE   A 1 279 ? 43.23962 -31.40287 -46.62303 1.000 36.47945 ?  813  ILE   A C   1 
ATOM   1929 O  O   . ILE   A 1 279 ? 42.36094 -30.67814 -46.12896 1.000 40.51916 ?  813  ILE   A O   1 
ATOM   1930 C  CB  . ILE   A 1 279 ? 43.71308 -33.69232 -45.59865 1.000 38.99770 ?  813  ILE   A CB  1 
ATOM   1931 C  CG1 . ILE   A 1 279 ? 43.13045 -35.10158 -45.47060 1.000 38.93372 ?  813  ILE   A CG1 1 
ATOM   1932 C  CG2 . ILE   A 1 279 ? 43.61944 -32.96451 -44.26273 1.000 31.84462 ?  813  ILE   A CG2 1 
ATOM   1933 C  CD1 . ILE   A 1 279 ? 43.76949 -35.93270 -44.37461 1.000 36.42953 ?  813  ILE   A CD1 1 
ATOM   1934 N  N   . PRO   A 1 280 ? 44.38367 -30.86918 -47.07754 1.000 36.06680 ?  814  PRO   A N   1 
ATOM   1935 C  CA  . PRO   A 1 280 ? 44.56827 -29.40744 -47.00299 1.000 42.09845 ?  814  PRO   A CA  1 
ATOM   1936 C  C   . PRO   A 1 280 ? 43.52989 -28.61942 -47.78191 1.000 47.03787 ?  814  PRO   A C   1 
ATOM   1937 O  O   . PRO   A 1 280 ? 43.18725 -27.49972 -47.38017 1.000 47.15329 ?  814  PRO   A O   1 
ATOM   1938 C  CB  . PRO   A 1 280 ? 45.97779 -29.19740 -47.57800 1.000 39.15985 ?  814  PRO   A CB  1 
ATOM   1939 C  CG  . PRO   A 1 280 ? 46.65278 -30.50437 -47.43337 1.000 35.13044 ?  814  PRO   A CG  1 
ATOM   1940 C  CD  . PRO   A 1 280 ? 45.59089 -31.53756 -47.60122 1.000 33.49447 ?  814  PRO   A CD  1 
ATOM   1941 N  N   . SER   A 1 281 ? 43.02004 -29.16708 -48.88715 1.000 48.04279 ?  815  SER   A N   1 
ATOM   1942 C  CA  . SER   A 1 281 ? 41.98981 -28.47103 -49.65228 1.000 46.61047 ?  815  SER   A CA  1 
ATOM   1943 C  C   . SER   A 1 281 ? 40.65228 -28.49273 -48.91975 1.000 43.57855 ?  815  SER   A C   1 
ATOM   1944 O  O   . SER   A 1 281 ? 39.99719 -27.45392 -48.77454 1.000 43.79497 ?  815  SER   A O   1 
ATOM   1945 C  CB  . SER   A 1 281 ? 41.85881 -29.09419 -51.04207 1.000 39.33099 ?  815  SER   A CB  1 
ATOM   1946 O  OG  . SER   A 1 281 ? 42.59170 -30.30324 -51.12682 1.000 43.70115 ?  815  SER   A OG  1 
ATOM   1947 N  N   . MET   A 1 282 ? 40.22904 -29.67257 -48.45206 1.000 40.22663 ?  816  MET   A N   1 
ATOM   1948 C  CA  . MET   A 1 282 ? 38.99497 -29.76772 -47.67563 1.000 44.79674 ?  816  MET   A CA  1 
ATOM   1949 C  C   . MET   A 1 282 ? 39.03624 -28.87280 -46.44574 1.000 43.03855 ?  816  MET   A C   1 
ATOM   1950 O  O   . MET   A 1 282 ? 37.99975 -28.34742 -46.02293 1.000 45.26851 ?  816  MET   A O   1 
ATOM   1951 C  CB  . MET   A 1 282 ? 38.74169 -31.21572 -47.25410 1.000 47.33866 ?  816  MET   A CB  1 
ATOM   1952 C  CG  . MET   A 1 282 ? 38.84949 -32.23841 -48.37488 1.000 49.76047 ?  816  MET   A CG  1 
ATOM   1953 S  SD  . MET   A 1 282 ? 37.93688 -33.75348 -48.02497 1.000 62.36003 ?  816  MET   A SD  1 
ATOM   1954 C  CE  . MET   A 1 282 ? 39.26362 -34.95206 -48.09687 1.000 46.77774 ?  816  MET   A CE  1 
ATOM   1955 N  N   . GLN   A 1 283 ? 40.21862 -28.68959 -45.85986 1.000 39.58042 ?  817  GLN   A N   1 
ATOM   1956 C  CA  . GLN   A 1 283 ? 40.33440 -27.82679 -44.69185 1.000 39.83583 ?  817  GLN   A CA  1 
ATOM   1957 C  C   . GLN   A 1 283 ? 40.08934 -26.36904 -45.05852 1.000 39.99106 ?  817  GLN   A C   1 
ATOM   1958 O  O   . GLN   A 1 283 ? 39.42423 -25.64051 -44.31362 1.000 41.99180 ?  817  GLN   A O   1 
ATOM   1959 C  CB  . GLN   A 1 283 ? 41.70952 -27.99959 -44.05045 1.000 45.12622 ?  817  GLN   A CB  1 
ATOM   1960 C  CG  . GLN   A 1 283 ? 41.85700 -29.26399 -43.21576 1.000 38.72350 ?  817  GLN   A CG  1 
ATOM   1961 C  CD  . GLN   A 1 283 ? 40.92540 -29.29031 -42.02066 1.000 35.86516 ?  817  GLN   A CD  1 
ATOM   1962 O  OE1 . GLN   A 1 283 ? 39.75925 -29.66452 -42.13553 1.000 36.07380 ?  817  GLN   A OE1 1 
ATOM   1963 N  NE2 . GLN   A 1 283 ? 41.43900 -28.89315 -40.86172 1.000 32.93582 ?  817  GLN   A NE2 1 
ATOM   1964 N  N   . VAL   A 1 284 ? 40.61278 -25.92607 -46.20380 1.000 43.73663 ?  818  VAL   A N   1 
ATOM   1965 C  CA  . VAL   A 1 284 ? 40.40991 -24.54166 -46.61956 1.000 44.20978 ?  818  VAL   A CA  1 
ATOM   1966 C  C   . VAL   A 1 284 ? 38.94652 -24.29844 -46.97177 1.000 43.19165 ?  818  VAL   A C   1 
ATOM   1967 O  O   . VAL   A 1 284 ? 38.38137 -23.24890 -46.64129 1.000 41.21502 ?  818  VAL   A O   1 
ATOM   1968 C  CB  . VAL   A 1 284 ? 41.35045 -24.19306 -47.78814 1.000 46.20790 ?  818  VAL   A CB  1 
ATOM   1969 C  CG1 . VAL   A 1 284 ? 40.89847 -22.92014 -48.48537 1.000 45.10288 ?  818  VAL   A CG1 1 
ATOM   1970 C  CG2 . VAL   A 1 284 ? 42.77934 -24.04688 -47.28644 1.000 45.61503 ?  818  VAL   A CG2 1 
ATOM   1971 N  N   . GLY   A 1 285 ? 38.30557 -25.26446 -47.63378 1.000 43.71259 ?  819  GLY   A N   1 
ATOM   1972 C  CA  . GLY   A 1 285 ? 36.88610 -25.12977 -47.92361 1.000 39.35652 ?  819  GLY   A CA  1 
ATOM   1973 C  C   . GLY   A 1 285 ? 36.03464 -25.09642 -46.66824 1.000 40.03164 ?  819  GLY   A C   1 
ATOM   1974 O  O   . GLY   A 1 285 ? 35.10390 -24.29279 -46.55801 1.000 36.75235 ?  819  GLY   A O   1 
ATOM   1975 N  N   . PHE   A 1 286 ? 36.34409 -25.96872 -45.70400 1.000 41.39683 ?  820  PHE   A N   1 
ATOM   1976 C  CA  . PHE   A 1 286 ? 35.63591 -25.95819 -44.42688 1.000 39.24587 ?  820  PHE   A CA  1 
ATOM   1977 C  C   . PHE   A 1 286 ? 35.81431 -24.62673 -43.70733 1.000 35.08675 ?  820  PHE   A C   1 
ATOM   1978 O  O   . PHE   A 1 286 ? 34.85509 -24.07705 -43.15157 1.000 32.82703 ?  820  PHE   A O   1 
ATOM   1979 C  CB  . PHE   A 1 286 ? 36.12880 -27.11273 -43.55392 1.000 35.87943 ?  820  PHE   A CB  1 
ATOM   1980 C  CG  . PHE   A 1 286 ? 35.54870 -27.12457 -42.16806 1.000 35.74247 ?  820  PHE   A CG  1 
ATOM   1981 C  CD1 . PHE   A 1 286 ? 34.18313 -27.24541 -41.97257 1.000 38.07866 ?  820  PHE   A CD1 1 
ATOM   1982 C  CD2 . PHE   A 1 286 ? 36.37493 -27.03061 -41.05854 1.000 34.53330 ?  820  PHE   A CD2 1 
ATOM   1983 C  CE1 . PHE   A 1 286 ? 33.64996 -27.26127 -40.69511 1.000 41.50766 ?  820  PHE   A CE1 1 
ATOM   1984 C  CE2 . PHE   A 1 286 ? 35.84912 -27.04890 -39.77969 1.000 33.60140 ?  820  PHE   A CE2 1 
ATOM   1985 C  CZ  . PHE   A 1 286 ? 34.48523 -27.16245 -39.59747 1.000 39.96667 ?  820  PHE   A CZ  1 
ATOM   1986 N  N   . ILE   A 1 287 ? 37.03729 -24.09321 -43.70925 1.000 34.56980 ?  821  ILE   A N   1 
ATOM   1987 C  CA  . ILE   A 1 287 ? 37.29035 -22.78834 -43.10286 1.000 37.23216 ?  821  ILE   A CA  1 
ATOM   1988 C  C   . ILE   A 1 287 ? 36.54767 -21.69413 -43.86305 1.000 40.48543 ?  821  ILE   A C   1 
ATOM   1989 O  O   . ILE   A 1 287 ? 35.90327 -20.82401 -43.26450 1.000 38.75888 ?  821  ILE   A O   1 
ATOM   1990 C  CB  . ILE   A 1 287 ? 38.80434 -22.51138 -43.05130 1.000 35.30476 ?  821  ILE   A CB  1 
ATOM   1991 C  CG1 . ILE   A 1 287 ? 39.49702 -23.46102 -42.07241 1.000 35.14800 ?  821  ILE   A CG1 1 
ATOM   1992 C  CG2 . ILE   A 1 287 ? 39.07725 -21.06928 -42.67929 1.000 33.20757 ?  821  ILE   A CG2 1 
ATOM   1993 C  CD1 . ILE   A 1 287 ? 40.99898 -23.54291 -42.26259 1.000 39.03861 ?  821  ILE   A CD1 1 
ATOM   1994 N  N   . ASP   A 1 288 ? 36.62515 -21.72687 -45.19684 1.000 42.18492 ?  822  ASP   A N   1 
ATOM   1995 C  CA  . ASP   A 1 288 ? 36.00768 -20.68545 -46.01574 1.000 36.95013 ?  822  ASP   A CA  1 
ATOM   1996 C  C   . ASP   A 1 288 ? 34.50086 -20.61509 -45.79287 1.000 35.28845 ?  822  ASP   A C   1 
ATOM   1997 O  O   . ASP   A 1 288 ? 33.94844 -19.53784 -45.54113 1.000 37.84089 ?  822  ASP   A O   1 
ATOM   1998 C  CB  . ASP   A 1 288 ? 36.31352 -20.93210 -47.49472 1.000 44.98289 ?  822  ASP   A CB  1 
ATOM   1999 C  CG  . ASP   A 1 288 ? 37.54875 -20.19700 -47.96620 1.000 53.37130 ?  822  ASP   A CG  1 
ATOM   2000 O  OD1 . ASP   A 1 288 ? 38.12441 -20.60913 -48.99653 1.000 57.33417 ?  822  ASP   A OD1 1 
ATOM   2001 O  OD2 . ASP   A 1 288 ? 37.93936 -19.20774 -47.31206 1.000 49.67367 ?  822  ASP   A OD2 1 
ATOM   2002 N  N   . ALA   A 1 289 ? 33.82070 -21.75808 -45.87790 1.000 30.59003 ?  823  ALA   A N   1 
ATOM   2003 C  CA  . ALA   A 1 289 ? 32.36374 -21.80570 -45.84987 1.000 28.48686 ?  823  ALA   A CA  1 
ATOM   2004 C  C   . ALA   A 1 289 ? 31.76658 -21.73851 -44.45124 1.000 40.22490 ?  823  ALA   A C   1 
ATOM   2005 O  O   . ALA   A 1 289 ? 30.70112 -21.13776 -44.27486 1.000 47.97512 ?  823  ALA   A O   1 
ATOM   2006 C  CB  . ALA   A 1 289 ? 31.87088 -23.08199 -46.53009 1.000 24.55888 ?  823  ALA   A CB  1 
ATOM   2007 N  N   . ILE   A 1 290 ? 32.41202 -22.33067 -43.45350 1.000 37.03213 ?  824  ILE   A N   1 
ATOM   2008 C  CA  . ILE   A 1 290 ? 31.81480 -22.52978 -42.13894 1.000 35.16422 ?  824  ILE   A CA  1 
ATOM   2009 C  C   . ILE   A 1 290 ? 32.45040 -21.62546 -41.08701 1.000 40.50075 ?  824  ILE   A C   1 
ATOM   2010 O  O   . ILE   A 1 290 ? 31.75530 -20.86941 -40.40721 1.000 38.53296 ?  824  ILE   A O   1 
ATOM   2011 C  CB  . ILE   A 1 290 ? 31.89147 -24.01558 -41.71356 1.000 38.13616 ?  824  ILE   A CB  1 
ATOM   2012 C  CG1 . ILE   A 1 290 ? 31.32956 -24.92865 -42.80933 1.000 31.18338 ?  824  ILE   A CG1 1 
ATOM   2013 C  CG2 . ILE   A 1 290 ? 31.15215 -24.24002 -40.39901 1.000 31.27806 ?  824  ILE   A CG2 1 
ATOM   2014 C  CD1 . ILE   A 1 290 ? 29.94103 -24.54997 -43.29032 1.000 34.23502 ?  824  ILE   A CD1 1 
ATOM   2015 N  N   . CYS   A 1 291 ? 33.77595 -21.68210 -40.94796 1.000 38.64360 ?  825  CYS   A N   1 
ATOM   2016 C  CA  . CYS   A 1 291 ? 34.42354 -21.13589 -39.75835 1.000 33.43716 ?  825  CYS   A CA  1 
ATOM   2017 C  C   . CYS   A 1 291 ? 34.63371 -19.62647 -39.84410 1.000 36.17853 ?  825  CYS   A C   1 
ATOM   2018 O  O   . CYS   A 1 291 ? 34.31979 -18.90021 -38.89464 1.000 43.87869 ?  825  CYS   A O   1 
ATOM   2019 C  CB  . CYS   A 1 291 ? 35.75916 -21.84396 -39.52569 1.000 35.04675 ?  825  CYS   A CB  1 
ATOM   2020 S  SG  . CYS   A 1 291 ? 35.65165 -23.64497 -39.56383 1.000 41.36380 ?  825  CYS   A SG  1 
ATOM   2021 N  N   . LEU   A 1 292 ? 35.15961 -19.13868 -40.97147 1.000 34.00660 ?  826  LEU   A N   1 
ATOM   2022 C  CA  . LEU   A 1 292 ? 35.67651 -17.77197 -41.03795 1.000 39.25648 ?  826  LEU   A CA  1 
ATOM   2023 C  C   . LEU   A 1 292 ? 34.60282 -16.73769 -40.71456 1.000 41.52732 ?  826  LEU   A C   1 
ATOM   2024 O  O   . LEU   A 1 292 ? 34.77652 -15.90507 -39.81737 1.000 38.29599 ?  826  LEU   A O   1 
ATOM   2025 C  CB  . LEU   A 1 292 ? 36.27513 -17.50691 -42.41929 1.000 42.16346 ?  826  LEU   A CB  1 
ATOM   2026 C  CG  . LEU   A 1 292 ? 37.79160 -17.67914 -42.52269 1.000 38.16112 ?  826  LEU   A CG  1 
ATOM   2027 C  CD1 . LEU   A 1 292 ? 38.32151 -17.08623 -43.81922 1.000 49.11137 ?  826  LEU   A CD1 1 
ATOM   2028 C  CD2 . LEU   A 1 292 ? 38.49112 -17.06868 -41.31719 1.000 36.39342 ?  826  LEU   A CD2 1 
ATOM   2029 N  N   . GLN   A 1 293 ? 33.48533 -16.76807 -41.44601 1.000 43.15914 ?  827  GLN   A N   1 
ATOM   2030 C  CA  . GLN   A 1 293 ? 32.46253 -15.73928 -41.27310 1.000 39.44798 ?  827  GLN   A CA  1 
ATOM   2031 C  C   . GLN   A 1 293 ? 31.89374 -15.73178 -39.85961 1.000 43.59590 ?  827  GLN   A C   1 
ATOM   2032 O  O   . GLN   A 1 293 ? 31.49189 -14.67494 -39.35856 1.000 48.85876 ?  827  GLN   A O   1 
ATOM   2033 C  CB  . GLN   A 1 293 ? 31.34436 -15.93443 -42.29475 1.000 42.70827 ?  827  GLN   A CB  1 
ATOM   2034 C  CG  . GLN   A 1 293 ? 31.82728 -15.94575 -43.73027 1.000 49.65976 ?  827  GLN   A CG  1 
ATOM   2035 C  CD  . GLN   A 1 293 ? 30.82424 -16.56861 -44.67579 1.000 53.57673 ?  827  GLN   A CD  1 
ATOM   2036 O  OE1 . GLN   A 1 293 ? 31.19500 -17.25901 -45.62553 1.000 49.47218 ?  827  GLN   A OE1 1 
ATOM   2037 N  NE2 . GLN   A 1 293 ? 29.54338 -16.32531 -44.42322 1.000 45.57729 ?  827  GLN   A NE2 1 
ATOM   2038 N  N   . LEU   A 1 294 ? 31.85392 -16.89202 -39.20233 1.000 38.45672 ?  828  LEU   A N   1 
ATOM   2039 C  CA  . LEU   A 1 294 ? 31.36593 -16.95317 -37.82797 1.000 37.98479 ?  828  LEU   A CA  1 
ATOM   2040 C  C   . LEU   A 1 294 ? 32.33310 -16.26677 -36.87004 1.000 39.83910 ?  828  LEU   A C   1 
ATOM   2041 O  O   . LEU   A 1 294 ? 31.93450 -15.39739 -36.08535 1.000 38.84059 ?  828  LEU   A O   1 
ATOM   2042 C  CB  . LEU   A 1 294 ? 31.13975 -18.40926 -37.42050 1.000 40.26392 ?  828  LEU   A CB  1 
ATOM   2043 C  CG  . LEU   A 1 294 ? 31.02667 -18.72496 -35.92722 1.000 34.09660 ?  828  LEU   A CG  1 
ATOM   2044 C  CD1 . LEU   A 1 294 ? 29.68432 -18.27733 -35.36814 1.000 41.34524 ?  828  LEU   A CD1 1 
ATOM   2045 C  CD2 . LEU   A 1 294 ? 31.24170 -20.21095 -35.67581 1.000 36.47838 ?  828  LEU   A CD2 1 
ATOM   2046 N  N   . TYR   A 1 295 ? 33.61253 -16.64903 -36.91740 1.000 37.61093 ?  829  TYR   A N   1 
ATOM   2047 C  CA  . TYR   A 1 295 ? 34.60634 -16.02254 -36.05199 1.000 30.21081 ?  829  TYR   A CA  1 
ATOM   2048 C  C   . TYR   A 1 295 ? 34.79956 -14.55239 -36.39698 1.000 35.04397 ?  829  TYR   A C   1 
ATOM   2049 O  O   . TYR   A 1 295 ? 35.10404 -13.74615 -35.51105 1.000 34.07575 ?  829  TYR   A O   1 
ATOM   2050 C  CB  . TYR   A 1 295 ? 35.92745 -16.78258 -36.14487 1.000 28.35485 ?  829  TYR   A CB  1 
ATOM   2051 C  CG  . TYR   A 1 295 ? 35.84323 -18.18471 -35.58543 1.000 26.95117 ?  829  TYR   A CG  1 
ATOM   2052 C  CD1 . TYR   A 1 295 ? 35.55776 -18.40264 -34.24377 1.000 30.38569 ?  829  TYR   A CD1 1 
ATOM   2053 C  CD2 . TYR   A 1 295 ? 36.03094 -19.29038 -36.40289 1.000 24.14861 ?  829  TYR   A CD2 1 
ATOM   2054 C  CE1 . TYR   A 1 295 ? 35.47299 -19.68213 -33.73049 1.000 26.73663 ?  829  TYR   A CE1 1 
ATOM   2055 C  CE2 . TYR   A 1 295 ? 35.94440 -20.57202 -35.90087 1.000 26.29542 ?  829  TYR   A CE2 1 
ATOM   2056 C  CZ  . TYR   A 1 295 ? 35.66669 -20.76278 -34.56389 1.000 29.40843 ?  829  TYR   A CZ  1 
ATOM   2057 O  OH  . TYR   A 1 295 ? 35.58307 -22.03993 -34.05895 1.000 31.06595 ?  829  TYR   A OH  1 
ATOM   2058 N  N   . GLU   A 1 296 ? 34.63201 -14.18984 -37.67136 1.000 41.98551 ?  830  GLU   A N   1 
ATOM   2059 C  CA  . GLU   A 1 296 ? 34.55810 -12.78148 -38.04632 1.000 40.51527 ?  830  GLU   A CA  1 
ATOM   2060 C  C   . GLU   A 1 296 ? 33.47206 -12.06837 -37.25466 1.000 47.38489 ?  830  GLU   A C   1 
ATOM   2061 O  O   . GLU   A 1 296 ? 33.71849 -11.03868 -36.61586 1.000 45.76176 ?  830  GLU   A O   1 
ATOM   2062 C  CB  . GLU   A 1 296 ? 34.27267 -12.64688 -39.54220 1.000 42.20281 ?  830  GLU   A CB  1 
ATOM   2063 C  CG  . GLU   A 1 296 ? 35.46673 -12.80541 -40.45832 1.000 44.28493 ?  830  GLU   A CG  1 
ATOM   2064 C  CD  . GLU   A 1 296 ? 35.07893 -12.67203 -41.91964 1.000 57.27279 ?  830  GLU   A CD  1 
ATOM   2065 O  OE1 . GLU   A 1 296 ? 34.07191 -11.98858 -42.20846 1.000 62.72767 ?  830  GLU   A OE1 1 
ATOM   2066 O  OE2 . GLU   A 1 296 ? 35.77391 -13.25431 -42.77764 1.000 54.54756 ?  830  GLU   A OE2 1 
ATOM   2067 N  N   . ALA   A 1 297 ? 32.25386 -12.61197 -37.29308 1.000 41.31413 ?  831  ALA   A N   1 
ATOM   2068 C  CA  . ALA   A 1 297 ? 31.11944 -11.95915 -36.65100 1.000 41.95753 ?  831  ALA   A CA  1 
ATOM   2069 C  C   . ALA   A 1 297 ? 31.27751 -11.92671 -35.13610 1.000 47.24778 ?  831  ALA   A C   1 
ATOM   2070 O  O   . ALA   A 1 297 ? 30.95819 -10.91756 -34.49669 1.000 50.64793 ?  831  ALA   A O   1 
ATOM   2071 C  CB  . ALA   A 1 297 ? 29.82353 -12.66579 -37.04358 1.000 49.32245 ?  831  ALA   A CB  1 
ATOM   2072 N  N   . LEU   A 1 298 ? 31.76515 -13.01963 -34.54209 1.000 46.46968 ?  832  LEU   A N   1 
ATOM   2073 C  CA  . LEU   A 1 298 ? 31.97869 -13.03426 -33.09856 1.000 43.27669 ?  832  LEU   A CA  1 
ATOM   2074 C  C   . LEU   A 1 298 ? 33.03839 -12.02298 -32.68434 1.000 47.42797 ?  832  LEU   A C   1 
ATOM   2075 O  O   . LEU   A 1 298 ? 32.96842 -11.46567 -31.58278 1.000 50.49455 ?  832  LEU   A O   1 
ATOM   2076 C  CB  . LEU   A 1 298 ? 32.36946 -14.43830 -32.63635 1.000 48.68130 ?  832  LEU   A CB  1 
ATOM   2077 C  CG  . LEU   A 1 298 ? 32.50849 -14.65348 -31.12681 1.000 53.08561 ?  832  LEU   A CG  1 
ATOM   2078 C  CD1 . LEU   A 1 298 ? 31.28617 -14.12534 -30.39086 1.000 51.55985 ?  832  LEU   A CD1 1 
ATOM   2079 C  CD2 . LEU   A 1 298 ? 32.73142 -16.12424 -30.81355 1.000 48.15475 ?  832  LEU   A CD2 1 
ATOM   2080 N  N   . THR   A 1 299 ? 34.02247 -11.77225 -33.55131 1.000 47.93077 ?  833  THR   A N   1 
ATOM   2081 C  CA  . THR   A 1 299 ? 35.02218 -10.74925 -33.26341 1.000 49.11454 ?  833  THR   A CA  1 
ATOM   2082 C  C   . THR   A 1 299 ? 34.38312 -9.36686  -33.19215 1.000 50.92490 ?  833  THR   A C   1 
ATOM   2083 O  O   . THR   A 1 299 ? 34.77166 -8.53560  -32.36256 1.000 53.80496 ?  833  THR   A O   1 
ATOM   2084 C  CB  . THR   A 1 299 ? 36.12766 -10.79315 -34.32194 1.000 47.20596 ?  833  THR   A CB  1 
ATOM   2085 O  OG1 . THR   A 1 299 ? 37.04316 -11.85144 -34.01085 1.000 51.04688 ?  833  THR   A OG1 1 
ATOM   2086 C  CG2 . THR   A 1 299 ? 36.89157 -9.47665  -34.38065 1.000 44.10553 ?  833  THR   A CG2 1 
ATOM   2087 N  N   . HIS   A 1 300 ? 33.38675 -9.10967  -34.04293 1.000 48.97971 ?  834  HIS   A N   1 
ATOM   2088 C  CA  . HIS   A 1 300 ? 32.66504 -7.84201  -33.98149 1.000 46.03120 ?  834  HIS   A CA  1 
ATOM   2089 C  C   . HIS   A 1 300 ? 32.00159 -7.65454  -32.62238 1.000 52.98769 ?  834  HIS   A C   1 
ATOM   2090 O  O   . HIS   A 1 300 ? 32.14520 -6.60353  -31.98689 1.000 64.32479 ?  834  HIS   A O   1 
ATOM   2091 C  CB  . HIS   A 1 300 ? 31.61886 -7.77559  -35.09459 1.000 45.44955 ?  834  HIS   A CB  1 
ATOM   2092 C  CG  . HIS   A 1 300 ? 32.19791 -7.63604  -36.46742 1.000 56.85440 ?  834  HIS   A CG  1 
ATOM   2093 N  ND1 . HIS   A 1 300 ? 31.43834 -7.27685  -37.55991 1.000 59.06842 ?  834  HIS   A ND1 1 
ATOM   2094 C  CD2 . HIS   A 1 300 ? 33.45969 -7.80888  -36.92709 1.000 62.01327 ?  834  HIS   A CD2 1 
ATOM   2095 C  CE1 . HIS   A 1 300 ? 32.20678 -7.23425  -38.63335 1.000 54.61895 ?  834  HIS   A CE1 1 
ATOM   2096 N  NE2 . HIS   A 1 300 ? 33.43808 -7.55265  -38.27672 1.000 58.56814 ?  834  HIS   A NE2 1 
ATOM   2097 N  N   . VAL   A 1 301 ? 31.26837 -8.67063  -32.16090 1.000 46.94768 ?  835  VAL   A N   1 
ATOM   2098 C  CA  . VAL   A 1 301 ? 30.55481 -8.56590  -30.88946 1.000 41.97908 ?  835  VAL   A CA  1 
ATOM   2099 C  C   . VAL   A 1 301 ? 31.54086 -8.41933  -29.73664 1.000 48.68904 ?  835  VAL   A C   1 
ATOM   2100 O  O   . VAL   A 1 301 ? 31.37844 -7.56308  -28.85861 1.000 50.73662 ?  835  VAL   A O   1 
ATOM   2101 C  CB  . VAL   A 1 301 ? 29.63078 -9.78099  -30.69412 1.000 39.81850 ?  835  VAL   A CB  1 
ATOM   2102 C  CG1 . VAL   A 1 301 ? 29.26601 -9.94705  -29.22773 1.000 43.35596 ?  835  VAL   A CG1 1 
ATOM   2103 C  CG2 . VAL   A 1 301 ? 28.37694 -9.62815  -31.53788 1.000 39.41032 ?  835  VAL   A CG2 1 
ATOM   2104 N  N   . SER   A 1 302 ? 32.58148 -9.24895  -29.72568 1.000 52.39953 ?  836  SER   A N   1 
ATOM   2105 C  CA  . SER   A 1 302 ? 33.61503 -9.21131  -28.69302 1.000 51.09046 ?  836  SER   A CA  1 
ATOM   2106 C  C   . SER   A 1 302 ? 34.97030 -9.15545  -29.39066 1.000 54.85671 ?  836  SER   A C   1 
ATOM   2107 O  O   . SER   A 1 302 ? 35.44398 -10.16471 -29.92162 1.000 51.68781 ?  836  SER   A O   1 
ATOM   2108 C  CB  . SER   A 1 302 ? 33.51315 -10.41896 -27.76710 1.000 51.11407 ?  836  SER   A CB  1 
ATOM   2109 O  OG  . SER   A 1 302 ? 34.68533 -10.55900 -26.98348 1.000 47.30277 ?  836  SER   A OG  1 
ATOM   2110 N  N   . GLU   A 1 303 ? 35.59071 -7.97301  -29.39254 1.000 53.03019 ?  837  GLU   A N   1 
ATOM   2111 C  CA  . GLU   A 1 303 ? 36.90359 -7.81324  -30.00607 1.000 49.70604 ?  837  GLU   A CA  1 
ATOM   2112 C  C   . GLU   A 1 303 ? 37.97930 -8.63653  -29.31049 1.000 50.99024 ?  837  GLU   A C   1 
ATOM   2113 O  O   . GLU   A 1 303 ? 39.07508 -8.78504  -29.86278 1.000 60.26190 ?  837  GLU   A O   1 
ATOM   2114 C  CB  . GLU   A 1 303 ? 37.30465 -6.33552  -30.01338 1.000 59.71941 ?  837  GLU   A CB  1 
ATOM   2115 C  CG  . GLU   A 1 303 ? 36.64889 -5.50928  -31.11541 1.000 71.51308 ?  837  GLU   A CG  1 
ATOM   2116 C  CD  . GLU   A 1 303 ? 37.23911 -5.77720  -32.48952 1.000 70.46925 ?  837  GLU   A CD  1 
ATOM   2117 O  OE1 . GLU   A 1 303 ? 38.26301 -6.48848  -32.57676 1.000 74.67197 ?  837  GLU   A OE1 1 
ATOM   2118 O  OE2 . GLU   A 1 303 ? 36.67874 -5.27126  -33.48497 1.000 66.36346 ?  837  GLU   A OE2 1 
ATOM   2119 N  N   . ASP   A 1 304 ? 37.69969 -9.16501  -28.12092 1.000 48.39221 ?  838  ASP   A N   1 
ATOM   2120 C  CA  . ASP   A 1 304 ? 38.61562 -10.04965 -27.41648 1.000 49.93117 ?  838  ASP   A CA  1 
ATOM   2121 C  C   . ASP   A 1 304 ? 38.41472 -11.51511 -27.78073 1.000 48.53619 ?  838  ASP   A C   1 
ATOM   2122 O  O   . ASP   A 1 304 ? 39.18263 -12.36521 -27.31733 1.000 43.88818 ?  838  ASP   A O   1 
ATOM   2123 C  CB  . ASP   A 1 304 ? 38.47757 -9.85717  -25.90307 1.000 57.22168 ?  838  ASP   A CB  1 
ATOM   2124 C  CG  . ASP   A 1 304 ? 37.87377 -8.51374  -25.53810 1.000 54.79921 ?  838  ASP   A CG  1 
ATOM   2125 O  OD1 . ASP   A 1 304 ? 37.16789 -7.92157  -26.38143 1.000 56.60999 ?  838  ASP   A OD1 1 
ATOM   2126 O  OD2 . ASP   A 1 304 ? 38.11750 -8.04282  -24.40840 1.000 55.40580 ?  838  ASP   A OD2 1 
ATOM   2127 N  N   . CYS   A 1 305 ? 37.40257 -11.83001 -28.58840 1.000 53.32191 ?  839  CYS   A N   1 
ATOM   2128 C  CA  . CYS   A 1 305 ? 37.30018 -13.13094 -29.23707 1.000 47.36942 ?  839  CYS   A CA  1 
ATOM   2129 C  C   . CYS   A 1 305 ? 38.13294 -13.19934 -30.50958 1.000 41.19131 ?  839  CYS   A C   1 
ATOM   2130 O  O   . CYS   A 1 305 ? 38.01557 -14.16813 -31.26814 1.000 46.23972 ?  839  CYS   A O   1 
ATOM   2131 C  CB  . CYS   A 1 305 ? 35.83756 -13.45514 -29.55448 1.000 49.68415 ?  839  CYS   A CB  1 
ATOM   2132 S  SG  . CYS   A 1 305 ? 34.81450 -13.81907 -28.10960 1.000 46.62271 ?  839  CYS   A SG  1 
ATOM   2133 N  N   . PHE   A 1 306 ? 38.95973 -12.18284 -30.74688 1.000 39.83274 ?  840  PHE   A N   1 
ATOM   2134 C  CA  . PHE   A 1 306 ? 39.78254 -12.13921 -31.95207 1.000 41.59473 ?  840  PHE   A CA  1 
ATOM   2135 C  C   . PHE   A 1 306 ? 40.79528 -13.27524 -32.06288 1.000 42.56390 ?  840  PHE   A C   1 
ATOM   2136 O  O   . PHE   A 1 306 ? 41.06014 -13.70743 -33.19887 1.000 37.45285 ?  840  PHE   A O   1 
ATOM   2137 C  CB  . PHE   A 1 306 ? 40.48849 -10.78018 -32.02946 1.000 36.93080 ?  840  PHE   A CB  1 
ATOM   2138 C  CG  . PHE   A 1 306 ? 41.46126 -10.66452 -33.16675 1.000 39.31666 ?  840  PHE   A CG  1 
ATOM   2139 C  CD1 . PHE   A 1 306 ? 41.01482 -10.39140 -34.44864 1.000 37.77538 ?  840  PHE   A CD1 1 
ATOM   2140 C  CD2 . PHE   A 1 306 ? 42.82298 -10.81883 -32.95377 1.000 39.66243 ?  840  PHE   A CD2 1 
ATOM   2141 C  CE1 . PHE   A 1 306 ? 41.90474 -10.28119 -35.50029 1.000 33.66703 ?  840  PHE   A CE1 1 
ATOM   2142 C  CE2 . PHE   A 1 306 ? 43.71969 -10.70895 -34.00157 1.000 39.37625 ?  840  PHE   A CE2 1 
ATOM   2143 C  CZ  . PHE   A 1 306 ? 43.25921 -10.44013 -35.27682 1.000 38.83039 ?  840  PHE   A CZ  1 
ATOM   2144 N  N   . PRO   A 1 307 ? 41.41479 -13.77488 -30.98098 1.000 37.80295 ?  841  PRO   A N   1 
ATOM   2145 C  CA  . PRO   A 1 307 ? 42.32410 -14.92392 -31.13650 1.000 35.34174 ?  841  PRO   A CA  1 
ATOM   2146 C  C   . PRO   A 1 307 ? 41.71390 -16.09661 -31.88322 1.000 38.60913 ?  841  PRO   A C   1 
ATOM   2147 O  O   . PRO   A 1 307 ? 42.44167 -16.83365 -32.56150 1.000 39.02841 ?  841  PRO   A O   1 
ATOM   2148 C  CB  . PRO   A 1 307 ? 42.65838 -15.28829 -29.68561 1.000 32.09559 ?  841  PRO   A CB  1 
ATOM   2149 C  CG  . PRO   A 1 307 ? 42.62705 -13.98657 -28.98618 1.000 31.70629 ?  841  PRO   A CG  1 
ATOM   2150 C  CD  . PRO   A 1 307 ? 41.48694 -13.22566 -29.61179 1.000 35.42261 ?  841  PRO   A CD  1 
ATOM   2151 N  N   . LEU   A 1 308 ? 40.39651 -16.28632 -31.79223 1.000 40.57710 ?  842  LEU   A N   1 
ATOM   2152 C  CA  . LEU   A 1 308 ? 39.74878 -17.34742 -32.55507 1.000 39.95591 ?  842  LEU   A CA  1 
ATOM   2153 C  C   . LEU   A 1 308 ? 39.70652 -17.00256 -34.03859 1.000 37.93422 ?  842  LEU   A C   1 
ATOM   2154 O  O   . LEU   A 1 308 ? 40.01724 -17.84199 -34.89117 1.000 44.38257 ?  842  LEU   A O   1 
ATOM   2155 C  CB  . LEU   A 1 308 ? 38.34383 -17.59750 -32.00762 1.000 40.14381 ?  842  LEU   A CB  1 
ATOM   2156 C  CG  . LEU   A 1 308 ? 38.31579 -17.96622 -30.52278 1.000 38.84990 ?  842  LEU   A CG  1 
ATOM   2157 C  CD1 . LEU   A 1 308 ? 36.88937 -18.07864 -30.00989 1.000 32.75219 ?  842  LEU   A CD1 1 
ATOM   2158 C  CD2 . LEU   A 1 308 ? 39.08040 -19.25975 -30.28457 1.000 36.40148 ?  842  LEU   A CD2 1 
ATOM   2159 N  N   . LEU   A 1 309 ? 39.33256 -15.76445 -34.36576 1.000 38.71546 ?  843  LEU   A N   1 
ATOM   2160 C  CA  . LEU   A 1 309 ? 39.37188 -15.32257 -35.75606 1.000 35.27212 ?  843  LEU   A CA  1 
ATOM   2161 C  C   . LEU   A 1 309 ? 40.79276 -15.37661 -36.30435 1.000 36.40065 ?  843  LEU   A C   1 
ATOM   2162 O  O   . LEU   A 1 309 ? 41.02497 -15.86125 -37.41812 1.000 36.02334 ?  843  LEU   A O   1 
ATOM   2163 C  CB  . LEU   A 1 309 ? 38.80389 -13.90707 -35.86988 1.000 33.73913 ?  843  LEU   A CB  1 
ATOM   2164 C  CG  . LEU   A 1 309 ? 39.06244 -13.15631 -37.17968 1.000 30.27331 ?  843  LEU   A CG  1 
ATOM   2165 C  CD1 . LEU   A 1 309 ? 38.50015 -13.91924 -38.37459 1.000 33.58831 ?  843  LEU   A CD1 1 
ATOM   2166 C  CD2 . LEU   A 1 309 ? 38.49353 -11.74389 -37.12060 1.000 29.50938 ?  843  LEU   A CD2 1 
ATOM   2167 N  N   . ASP   A 1 310 ? 41.76015 -14.88611 -35.52689 1.000 35.02328 ?  844  ASP   A N   1 
ATOM   2168 C  CA  . ASP   A 1 310 ? 43.14586 -14.86251 -35.98440 1.000 37.31220 ?  844  ASP   A CA  1 
ATOM   2169 C  C   . ASP   A 1 310 ? 43.70195 -16.27235 -36.14341 1.000 44.38266 ?  844  ASP   A C   1 
ATOM   2170 O  O   . ASP   A 1 310 ? 44.30384 -16.59861 -37.17341 1.000 49.92438 ?  844  ASP   A O   1 
ATOM   2171 C  CB  . ASP   A 1 310 ? 44.00391 -14.05447 -35.01167 1.000 44.74086 ?  844  ASP   A CB  1 
ATOM   2172 C  CG  . ASP   A 1 310 ? 45.42170 -13.85598 -35.51158 1.000 56.39027 ?  844  ASP   A CG  1 
ATOM   2173 O  OD1 . ASP   A 1 310 ? 46.36668 -14.21458 -34.77750 1.000 54.35416 ?  844  ASP   A OD1 1 
ATOM   2174 O  OD2 . ASP   A 1 310 ? 45.59248 -13.34015 -36.63664 1.000 59.58790 ?  844  ASP   A OD2 1 
ATOM   2175 N  N   . GLY   A 1 311 ? 43.51525 -17.12059 -35.12886 1.000 39.63536 ?  845  GLY   A N   1 
ATOM   2176 C  CA  . GLY   A 1 311 ? 44.03179 -18.47838 -35.20639 1.000 34.99045 ?  845  GLY   A CA  1 
ATOM   2177 C  C   . GLY   A 1 311 ? 43.45687 -19.26067 -36.37172 1.000 37.81465 ?  845  GLY   A C   1 
ATOM   2178 O  O   . GLY   A 1 311 ? 44.15732 -20.05425 -37.00516 1.000 40.84276 ?  845  GLY   A O   1 
ATOM   2179 N  N   . CYS   A 1 312 ? 42.17226 -19.04959 -36.66895 1.000 36.91548 ?  846  CYS   A N   1 
ATOM   2180 C  CA  . CYS   A 1 312 ? 41.56401 -19.69374 -37.82880 1.000 36.50000 ?  846  CYS   A CA  1 
ATOM   2181 C  C   . CYS   A 1 312 ? 42.24030 -19.24894 -39.11937 1.000 38.01670 ?  846  CYS   A C   1 
ATOM   2182 O  O   . CYS   A 1 312 ? 42.44523 -20.05572 -40.03433 1.000 37.24963 ?  846  CYS   A O   1 
ATOM   2183 C  CB  . CYS   A 1 312 ? 40.06640 -19.38562 -37.86958 1.000 30.99053 ?  846  CYS   A CB  1 
ATOM   2184 S  SG  . CYS   A 1 312 ? 39.17963 -20.09927 -39.27106 1.000 28.76893 ?  846  CYS   A SG  1 
ATOM   2185 N  N   . ARG   A 1 313 ? 42.59848 -17.96647 -39.20709 1.000 44.57734 ?  847  ARG   A N   1 
ATOM   2186 C  CA  . ARG   A 1 313 ? 43.28751 -17.46101 -40.38969 1.000 39.57346 ?  847  ARG   A CA  1 
ATOM   2187 C  C   . ARG   A 1 313 ? 44.67399 -18.07618 -40.52162 1.000 39.01889 ?  847  ARG   A C   1 
ATOM   2188 O  O   . ARG   A 1 313 ? 45.05937 -18.53626 -41.60307 1.000 46.31710 ?  847  ARG   A O   1 
ATOM   2189 C  CB  . ARG   A 1 313 ? 43.38834 -15.93843 -40.32558 1.000 30.86434 ?  847  ARG   A CB  1 
ATOM   2190 C  CG  . ARG   A 1 313 ? 42.11462 -15.20461 -40.68298 1.000 26.53829 ?  847  ARG   A CG  1 
ATOM   2191 C  CD  . ARG   A 1 313 ? 42.05857 -13.87795 -39.95290 1.000 32.77594 ?  847  ARG   A CD  1 
ATOM   2192 N  NE  . ARG   A 1 313 ? 41.00570 -13.00929 -40.46222 1.000 43.60634 ?  847  ARG   A NE  1 
ATOM   2193 C  CZ  . ARG   A 1 313 ? 40.89834 -11.71948 -40.17465 1.000 45.76375 ?  847  ARG   A CZ  1 
ATOM   2194 N  NH1 . ARG   A 1 313 ? 41.76655 -11.11380 -39.38054 1.000 37.51402 ?  847  ARG   A NH1 1 
ATOM   2195 N  NH2 . ARG   A 1 313 ? 39.89476 -11.01979 -40.69639 1.000 35.88389 ?  847  ARG   A NH2 1 
ATOM   2196 N  N   . LYS   A 1 314 ? 45.44112 -18.08501 -39.42662 1.000 39.74692 ?  848  LYS   A N   1 
ATOM   2197 C  CA  . LYS   A 1 314 ? 46.78132 -18.66158 -39.45740 1.000 45.38775 ?  848  LYS   A CA  1 
ATOM   2198 C  C   . LYS   A 1 314 ? 46.75631 -20.11404 -39.91151 1.000 46.04019 ?  848  LYS   A C   1 
ATOM   2199 O  O   . LYS   A 1 314 ? 47.71188 -20.58352 -40.53865 1.000 49.72667 ?  848  LYS   A O   1 
ATOM   2200 C  CB  . LYS   A 1 314 ? 47.43488 -18.54915 -38.07933 1.000 42.23786 ?  848  LYS   A CB  1 
ATOM   2201 C  CG  . LYS   A 1 314 ? 47.89867 -17.14819 -37.71555 1.000 39.68571 ?  848  LYS   A CG  1 
ATOM   2202 C  CD  . LYS   A 1 314 ? 48.54139 -17.12547 -36.33733 1.000 43.68973 ?  848  LYS   A CD  1 
ATOM   2203 C  CE  . LYS   A 1 314 ? 49.42229 -15.89937 -36.15374 1.000 46.27329 ?  848  LYS   A CE  1 
ATOM   2204 N  NZ  . LYS   A 1 314 ? 48.63850 -14.70613 -35.72736 1.000 49.58400 ?  848  LYS   A NZ  1 
ATOM   2205 N  N   . ASN   A 1 315 ? 45.67505 -20.83615 -39.61382 1.000 42.09868 ?  849  ASN   A N   1 
ATOM   2206 C  CA  . ASN   A 1 315 ? 45.55032 -22.21322 -40.07362 1.000 40.41511 ?  849  ASN   A CA  1 
ATOM   2207 C  C   . ASN   A 1 315 ? 45.12409 -22.28953 -41.53385 1.000 41.94394 ?  849  ASN   A C   1 
ATOM   2208 O  O   . ASN   A 1 315 ? 45.53829 -23.21070 -42.24627 1.000 42.42212 ?  849  ASN   A O   1 
ATOM   2209 C  CB  . ASN   A 1 315 ? 44.55842 -22.97100 -39.19020 1.000 36.72246 ?  849  ASN   A CB  1 
ATOM   2210 C  CG  . ASN   A 1 315 ? 45.11577 -23.26392 -37.80986 1.000 33.67088 ?  849  ASN   A CG  1 
ATOM   2211 O  OD1 . ASN   A 1 315 ? 45.92225 -24.17665 -37.63520 1.000 38.88432 ?  849  ASN   A OD1 1 
ATOM   2212 N  ND2 . ASN   A 1 315 ? 44.68737 -22.48827 -36.82043 1.000 39.28258 ?  849  ASN   A ND2 1 
ATOM   2213 N  N   . ARG   A 1 316 ? 44.30389 -21.34048 -41.99453 1.000 44.30575 ?  850  ARG   A N   1 
ATOM   2214 C  CA  . ARG   A 1 316 ? 43.93775 -21.30410 -43.40708 1.000 43.82052 ?  850  ARG   A CA  1 
ATOM   2215 C  C   . ARG   A 1 316 ? 45.16083 -21.07113 -44.28300 1.000 41.63584 ?  850  ARG   A C   1 
ATOM   2216 O  O   . ARG   A 1 316 ? 45.29994 -21.68796 -45.34500 1.000 41.14626 ?  850  ARG   A O   1 
ATOM   2217 C  CB  . ARG   A 1 316 ? 42.88956 -20.21873 -43.65507 1.000 40.27858 ?  850  ARG   A CB  1 
ATOM   2218 C  CG  . ARG   A 1 316 ? 42.07022 -20.42622 -44.92040 1.000 40.26362 ?  850  ARG   A CG  1 
ATOM   2219 C  CD  . ARG   A 1 316 ? 41.81503 -19.11112 -45.63997 1.000 41.65921 ?  850  ARG   A CD  1 
ATOM   2220 N  NE  . ARG   A 1 316 ? 41.06479 -19.29969 -46.87624 1.000 47.56163 ?  850  ARG   A NE  1 
ATOM   2221 C  CZ  . ARG   A 1 316 ? 41.60402 -19.30088 -48.08790 1.000 44.93721 ?  850  ARG   A CZ  1 
ATOM   2222 N  NH1 . ARG   A 1 316 ? 42.90401 -19.13229 -48.26633 1.000 44.31610 ?  850  ARG   A NH1 1 
ATOM   2223 N  NH2 . ARG   A 1 316 ? 40.81945 -19.47776 -49.14726 1.000 46.46928 ?  850  ARG   A NH2 1 
ATOM   2224 N  N   . GLN   A 1 317 ? 46.05790 -20.18168 -43.85278 1.000 48.21777 ?  851  GLN   A N   1 
ATOM   2225 C  CA  . GLN   A 1 317 ? 47.28390 -19.93311 -44.60455 1.000 50.38520 ?  851  GLN   A CA  1 
ATOM   2226 C  C   . GLN   A 1 317 ? 48.14349 -21.18917 -44.68186 1.000 45.80364 ?  851  GLN   A C   1 
ATOM   2227 O  O   . GLN   A 1 317 ? 48.64669 -21.54636 -45.75331 1.000 43.38554 ?  851  GLN   A O   1 
ATOM   2228 C  CB  . GLN   A 1 317 ? 48.06290 -18.78349 -43.96434 1.000 46.98168 ?  851  GLN   A CB  1 
ATOM   2229 C  CG  . GLN   A 1 317 ? 49.10561 -18.15142 -44.87210 1.000 53.49572 ?  851  GLN   A CG  1 
ATOM   2230 C  CD  . GLN   A 1 317 ? 50.51955 -18.56070 -44.50788 1.000 60.72383 ?  851  GLN   A CD  1 
ATOM   2231 O  OE1 . GLN   A 1 317 ? 50.88176 -18.60339 -43.33205 1.000 61.94056 ?  851  GLN   A OE1 1 
ATOM   2232 N  NE2 . GLN   A 1 317 ? 51.32823 -18.86173 -45.51800 1.000 52.63581 ?  851  GLN   A NE2 1 
ATOM   2233 N  N   . LYS   A 1 318 ? 48.32408 -21.87330 -43.54834 1.000 45.05813 ?  852  LYS   A N   1 
ATOM   2234 C  CA  . LYS   A 1 318 ? 49.09651 -23.11205 -43.54609 1.000 42.12239 ?  852  LYS   A CA  1 
ATOM   2235 C  C   . LYS   A 1 318 ? 48.43882 -24.17163 -44.41958 1.000 43.35031 ?  852  LYS   A C   1 
ATOM   2236 O  O   . LYS   A 1 318 ? 49.11953 -24.87231 -45.17790 1.000 45.71490 ?  852  LYS   A O   1 
ATOM   2237 C  CB  . LYS   A 1 318 ? 49.26094 -23.63030 -42.11756 1.000 42.95282 ?  852  LYS   A CB  1 
ATOM   2238 C  CG  . LYS   A 1 318 ? 49.92756 -22.65669 -41.16024 1.000 45.24434 ?  852  LYS   A CG  1 
ATOM   2239 C  CD  . LYS   A 1 318 ? 51.39007 -22.43241 -41.50375 1.000 51.77641 ?  852  LYS   A CD  1 
ATOM   2240 C  CE  . LYS   A 1 318 ? 52.29072 -22.92598 -40.38317 1.000 50.30086 ?  852  LYS   A CE  1 
ATOM   2241 N  NZ  . LYS   A 1 318 ? 52.68209 -21.82605 -39.45951 1.000 66.70248 ?  852  LYS   A NZ  1 
ATOM   2242 N  N   . TRP   A 1 319 ? 47.11356 -24.30621 -44.32363 1.000 45.72133 ?  853  TRP   A N   1 
ATOM   2243 C  CA  . TRP   A 1 319 ? 46.40901 -25.27948 -45.15006 1.000 43.01746 ?  853  TRP   A CA  1 
ATOM   2244 C  C   . TRP   A 1 319 ? 46.43751 -24.89187 -46.62252 1.000 47.74764 ?  853  TRP   A C   1 
ATOM   2245 O  O   . TRP   A 1 319 ? 46.48751 -25.77023 -47.49109 1.000 46.85822 ?  853  TRP   A O   1 
ATOM   2246 C  CB  . TRP   A 1 319 ? 44.96278 -25.43073 -44.67638 1.000 36.96928 ?  853  TRP   A CB  1 
ATOM   2247 C  CG  . TRP   A 1 319 ? 44.79240 -26.25271 -43.42823 1.000 40.01042 ?  853  TRP   A CG  1 
ATOM   2248 C  CD1 . TRP   A 1 319 ? 44.12350 -25.88790 -42.29602 1.000 42.05928 ?  853  TRP   A CD1 1 
ATOM   2249 C  CD2 . TRP   A 1 319 ? 45.28665 -27.57886 -43.19023 1.000 40.60171 ?  853  TRP   A CD2 1 
ATOM   2250 N  NE1 . TRP   A 1 319 ? 44.17352 -26.89889 -41.36810 1.000 38.29474 ?  853  TRP   A NE1 1 
ATOM   2251 C  CE2 . TRP   A 1 319 ? 44.88167 -27.94785 -41.89181 1.000 40.19007 ?  853  TRP   A CE2 1 
ATOM   2252 C  CE3 . TRP   A 1 319 ? 46.03397 -28.48762 -43.94625 1.000 36.72317 ?  853  TRP   A CE3 1 
ATOM   2253 C  CZ2 . TRP   A 1 319 ? 45.19781 -29.18447 -41.33433 1.000 42.08992 ?  853  TRP   A CZ2 1 
ATOM   2254 C  CZ3 . TRP   A 1 319 ? 46.34622 -29.71473 -43.39075 1.000 34.84111 ?  853  TRP   A CZ3 1 
ATOM   2255 C  CH2 . TRP   A 1 319 ? 45.92895 -30.05172 -42.09803 1.000 38.39679 ?  853  TRP   A CH2 1 
ATOM   2256 N  N   . GLN   A 1 320 ? 46.40321 -23.59073 -46.92334 1.000 53.92836 ?  854  GLN   A N   1 
ATOM   2257 C  CA  . GLN   A 1 320 ? 46.43476 -23.15486 -48.31641 1.000 48.02224 ?  854  GLN   A CA  1 
ATOM   2258 C  C   . GLN   A 1 320 ? 47.78723 -23.44261 -48.95623 1.000 50.50327 ?  854  GLN   A C   1 
ATOM   2259 O  O   . GLN   A 1 320 ? 47.85241 -23.88957 -50.10716 1.000 55.69445 ?  854  GLN   A O   1 
ATOM   2260 C  CB  . GLN   A 1 320 ? 46.10278 -21.66541 -48.41250 1.000 47.59796 ?  854  GLN   A CB  1 
ATOM   2261 C  CG  . GLN   A 1 320 ? 46.24996 -21.08171 -49.81080 1.000 46.92743 ?  854  GLN   A CG  1 
ATOM   2262 C  CD  . GLN   A 1 320 ? 45.32384 -21.73158 -50.82191 1.000 49.84663 ?  854  GLN   A CD  1 
ATOM   2263 O  OE1 . GLN   A 1 320 ? 44.25149 -22.22721 -50.47375 1.000 55.58739 ?  854  GLN   A OE1 1 
ATOM   2264 N  NE2 . GLN   A 1 320 ? 45.73632 -21.73275 -52.08417 1.000 48.31448 ?  854  GLN   A NE2 1 
ATOM   2265 N  N   . ALA   A 1 321 ? 48.87812 -23.18862 -48.22975 1.000 45.06630 ?  855  ALA   A N   1 
ATOM   2266 C  CA  . ALA   A 1 321 ? 50.20251 -23.48848 -48.76332 1.000 44.83396 ?  855  ALA   A CA  1 
ATOM   2267 C  C   . ALA   A 1 321 ? 50.37078 -24.98328 -49.01294 1.000 47.74952 ?  855  ALA   A C   1 
ATOM   2268 O  O   . ALA   A 1 321 ? 50.92229 -25.38963 -50.04251 1.000 51.90890 ?  855  ALA   A O   1 
ATOM   2269 C  CB  . ALA   A 1 321 ? 51.27952 -22.97374 -47.80982 1.000 43.52003 ?  855  ALA   A CB  1 
ATOM   2270 N  N   . LEU   A 1 322 ? 49.88888 -25.81684 -48.08554 1.000 46.56408 ?  856  LEU   A N   1 
ATOM   2271 C  CA  . LEU   A 1 322 ? 50.00592 -27.26437 -48.24428 1.000 44.72106 ?  856  LEU   A CA  1 
ATOM   2272 C  C   . LEU   A 1 322 ? 49.20966 -27.76184 -49.44361 1.000 47.81573 ?  856  LEU   A C   1 
ATOM   2273 O  O   . LEU   A 1 322 ? 49.68153 -28.62386 -50.19647 1.000 51.02981 ?  856  LEU   A O   1 
ATOM   2274 C  CB  . LEU   A 1 322 ? 49.54242 -27.97370 -46.97193 1.000 39.34665 ?  856  LEU   A CB  1 
ATOM   2275 C  CG  . LEU   A 1 322 ? 50.53955 -28.10248 -45.82184 1.000 42.65766 ?  856  LEU   A CG  1 
ATOM   2276 C  CD1 . LEU   A 1 322 ? 49.82203 -28.44621 -44.52607 1.000 42.17014 ?  856  LEU   A CD1 1 
ATOM   2277 C  CD2 . LEU   A 1 322 ? 51.58208 -29.15471 -46.15653 1.000 34.83757 ?  856  LEU   A CD2 1 
ATOM   2278 N  N   . ALA   A 1 323 ? 47.99858 -27.22846 -49.63359 1.000 50.81227 ?  857  ALA   A N   1 
ATOM   2279 C  CA  . ALA   A 1 323 ? 47.12883 -27.64546 -50.72875 1.000 46.86013 ?  857  ALA   A CA  1 
ATOM   2280 C  C   . ALA   A 1 323 ? 47.78255 -27.48516 -52.09343 1.000 51.89983 ?  857  ALA   A C   1 
ATOM   2281 O  O   . ALA   A 1 323 ? 47.40060 -28.18852 -53.03478 1.000 54.40551 ?  857  ALA   A O   1 
ATOM   2282 C  CB  . ALA   A 1 323 ? 45.82385 -26.85024 -50.68528 1.000 45.89845 ?  857  ALA   A CB  1 
ATOM   2283 N  N   . GLU   A 1 324 ? 48.75187 -26.58458 -52.22236 1.000 56.05647 ?  858  GLU   A N   1 
ATOM   2284 C  CA  . GLU   A 1 324 ? 49.48388 -26.38896 -53.46449 1.000 58.49663 ?  858  GLU   A CA  1 
ATOM   2285 C  C   . GLU   A 1 324 ? 50.70479 -27.29171 -53.57232 1.000 60.38869 ?  858  GLU   A C   1 
ATOM   2286 O  O   . GLU   A 1 324 ? 51.54452 -27.06926 -54.45045 1.000 64.65245 ?  858  GLU   A O   1 
ATOM   2287 C  CB  . GLU   A 1 324 ? 49.91129 -24.92493 -53.59653 1.000 52.80321 ?  858  GLU   A CB  1 
ATOM   2288 C  CG  . GLU   A 1 324 ? 48.76755 -23.93344 -53.48634 1.000 51.62492 ?  858  GLU   A CG  1 
ATOM   2289 C  CD  . GLU   A 1 324 ? 49.22027 -22.57943 -52.97465 1.000 56.06253 ?  858  GLU   A CD  1 
ATOM   2290 O  OE1 . GLU   A 1 324 ? 50.37573 -22.47041 -52.51161 1.000 50.00656 ?  858  GLU   A OE1 1 
ATOM   2291 O  OE2 . GLU   A 1 324 ? 48.41758 -21.62436 -53.03103 1.000 50.85116 ?  858  GLU   A OE2 1 
ATOM   2292 N  N   . GLN   A 1 325 ? 50.81827 -28.29450 -52.70251 1.000 56.71825 ?  859  GLN   A N   1 
ATOM   2293 C  CA  . GLN   A 1 325 ? 51.96959 -29.19650 -52.66942 1.000 56.92217 ?  859  GLN   A CA  1 
ATOM   2294 C  C   . GLN   A 1 325 ? 53.28170 -28.43363 -52.50940 1.000 60.75779 ?  859  GLN   A C   1 
ATOM   2295 O  O   . GLN   A 1 325 ? 53.46625 -27.69047 -51.54600 1.000 58.70720 ?  859  GLN   A O   1 
ATOM   2296 C  CB  . GLN   A 1 325 ? 52.02057 -30.06072 -53.93214 1.000 54.53966 ?  859  GLN   A CB  1 
ATOM   2297 C  CG  . GLN   A 1 325 ? 51.39276 -31.43282 -53.77414 1.000 56.54165 ?  859  GLN   A CG  1 
ATOM   2298 C  CD  . GLN   A 1 325 ? 49.88490 -31.39847 -53.89512 1.000 58.29099 ?  859  GLN   A CD  1 
ATOM   2299 O  OE1 . GLN   A 1 325 ? 49.16768 -31.55484 -52.90733 1.000 52.54947 ?  859  GLN   A OE1 1 
ATOM   2300 N  NE2 . GLN   A 1 325 ? 49.39404 -31.19232 -55.11178 1.000 58.86883 ?  859  GLN   A NE2 1 
HETATM 2301 C  C10 . A1ELC B 2 .   ? 37.51821 -34.55613 -44.26788 1.000 54.27093 ?  901  A1ELC A C10 1 
HETATM 2302 C  C11 . A1ELC B 2 .   ? 38.67971 -34.91079 -43.59420 1.000 49.57222 ?  901  A1ELC A C11 1 
HETATM 2303 C  C12 . A1ELC B 2 .   ? 39.87230 -36.52283 -44.88712 1.000 55.06051 ?  901  A1ELC A C12 1 
HETATM 2304 C  C13 . A1ELC B 2 .   ? 39.27828 -33.97796 -42.75433 1.000 50.70662 ?  901  A1ELC A C13 1 
HETATM 2305 C  C14 . A1ELC B 2 .   ? 38.72157 -32.73003 -42.56164 1.000 50.37593 ?  901  A1ELC A C14 1 
HETATM 2306 C  C15 . A1ELC B 2 .   ? 35.38835 -31.01590 -43.13438 1.000 38.94338 ?  901  A1ELC A C15 1 
HETATM 2307 C  C16 . A1ELC B 2 .   ? 34.71713 -31.83387 -42.02791 1.000 47.14337 ?  901  A1ELC A C16 1 
HETATM 2308 C  C17 . A1ELC B 2 .   ? 32.78490 -32.87175 -43.10187 1.000 60.21705 ?  901  A1ELC A C17 1 
HETATM 2309 C  C18 . A1ELC B 2 .   ? 31.31228 -33.14726 -43.10697 1.000 67.85862 ?  901  A1ELC A C18 1 
HETATM 2310 C  C19 . A1ELC B 2 .   ? 32.39572 -31.31274 -41.21704 1.000 49.86273 ?  901  A1ELC A C19 1 
HETATM 2311 C  C20 . A1ELC B 2 .   ? 32.81213 -31.64383 -39.79711 1.000 51.10276 ?  901  A1ELC A C20 1 
HETATM 2312 N  N   . A1ELC B 2 .   ? 34.60171 -30.91852 -38.37130 1.000 47.98743 ?  901  A1ELC A N   1 
HETATM 2313 C  C   . A1ELC B 2 .   ? 38.49467 -29.71960 -37.60651 1.000 41.20813 ?  901  A1ELC A C   1 
HETATM 2314 O  O   . A1ELC B 2 .   ? 39.26329 -36.14426 -43.65624 1.000 52.84302 ?  901  A1ELC A O   1 
HETATM 2315 C  C1  . A1ELC B 2 .   ? 37.57340 -29.79586 -36.57557 1.000 35.54031 ?  901  A1ELC A C1  1 
HETATM 2316 C  C2  . A1ELC B 2 .   ? 36.28978 -30.17446 -36.84448 1.000 38.89052 ?  901  A1ELC A C2  1 
HETATM 2317 C  C21 . A1ELC B 2 .   ? 36.84088 -30.39749 -39.20735 1.000 39.94317 ?  901  A1ELC A C21 1 
HETATM 2318 C  C22 . A1ELC B 2 .   ? 38.16076 -29.99629 -38.89930 1.000 41.76158 ?  901  A1ELC A C22 1 
HETATM 2319 C  C3  . A1ELC B 2 .   ? 35.88896 -30.49280 -38.16189 1.000 42.74888 ?  901  A1ELC A C3  1 
HETATM 2320 C  C4  . A1ELC B 2 .   ? 34.25348 -31.27868 -39.59585 1.000 50.10126 ?  901  A1ELC A C4  1 
HETATM 2321 C  C5  . A1ELC B 2 .   ? 35.11301 -31.26310 -40.68146 1.000 44.76985 ?  901  A1ELC A C5  1 
HETATM 2322 C  C6  . A1ELC B 2 .   ? 36.40949 -30.77593 -40.51017 1.000 40.74102 ?  901  A1ELC A C6  1 
HETATM 2323 C  C7  . A1ELC B 2 .   ? 36.91588 -31.02292 -42.96317 1.000 41.15046 ?  901  A1ELC A C7  1 
HETATM 2324 C  C8  . A1ELC B 2 .   ? 37.54876 -32.37925 -43.21581 1.000 49.60971 ?  901  A1ELC A C8  1 
HETATM 2325 C  C9  . A1ELC B 2 .   ? 36.96484 -33.30003 -44.07641 1.000 55.67348 ?  901  A1ELC A C9  1 
HETATM 2326 N  N1  . A1ELC B 2 .   ? 37.22597 -30.57589 -41.60817 1.000 45.75715 ?  901  A1ELC A N1  1 
HETATM 2327 N  N2  . A1ELC B 2 .   ? 33.26315 -32.02581 -42.16181 1.000 53.85102 ?  901  A1ELC A N2  1 
HETATM 2328 O  O1  . A1ELC B 2 .   ? 33.54163 -33.39802 -43.90559 1.000 57.23119 ?  901  A1ELC A O1  1 
HETATM 2329 BR BR  . A1ELC B 2 .   ? 40.28975 -29.25336 -37.19763 1.000 46.11675 ?  901  A1ELC A BR  1 
HETATM 2330 CL CL  . A1ELC B 2 .   ? 40.75923 -34.37797 -41.94528 1.000 60.08859 ?  901  A1ELC A CL  1 
HETATM 2331 ZN ZN  . ZN    C 3 .   ? 30.83743 -31.26348 -31.53316 1.000 36.32169 ?  902  ZN    A ZN  1 
HETATM 2332 MG MG  . MG    D 4 .   ? 27.22923 -33.44470 -33.12110 1.000 26.28336 ?  903  MG    A MG  1 
HETATM 2333 S  S   . SO4   E 5 .   ? 31.27546 -31.49585 -34.87133 1.000 29.47315 ?  904  SO4   A S   1 
HETATM 2334 O  O1  . SO4   E 5 .   ? 32.57140 -30.90035 -34.55723 1.000 25.94442 ?  904  SO4   A O1  1 
HETATM 2335 O  O2  . SO4   E 5 .   ? 30.22937 -30.48387 -34.76648 1.000 25.45464 ?  904  SO4   A O2  1 
HETATM 2336 O  O3  . SO4   E 5 .   ? 31.29495 -32.02323 -36.23284 1.000 40.23752 -1 904  SO4   A O3  1 
HETATM 2337 O  O4  . SO4   E 5 .   ? 30.99790 -32.57544 -33.93029 1.000 27.13789 ?  904  SO4   A O4  1 
HETATM 2338 O  O   . HOH   F 6 .   ? 29.35360 -34.07507 -34.50381 1.000 33.84540 ?  1001 HOH   A O   1 
HETATM 2339 O  O   . HOH   F 6 .   ? 28.92300 -31.80995 -32.99929 1.000 29.89181 ?  1002 HOH   A O   1 
HETATM 2340 O  O   . HOH   F 6 .   ? 42.52475 -21.33721 -30.35024 1.000 23.35556 ?  1003 HOH   A O   1 
HETATM 2341 O  O   . HOH   F 6 .   ? 15.14886 -33.37947 -37.07888 1.000 33.17694 ?  1004 HOH   A O   1 
HETATM 2342 O  O   . HOH   F 6 .   ? 26.42865 -17.19803 -3.10229  1.000 33.09827 ?  1005 HOH   A O   1 
HETATM 2343 O  O   . HOH   F 6 .   ? 26.93878 -32.20427 -31.54030 1.000 20.46506 ?  1006 HOH   A O   1 
HETATM 2344 O  O   . HOH   F 6 .   ? 15.94368 -39.45619 -12.50149 1.000 30.34248 ?  1007 HOH   A O   1 
HETATM 2345 O  O   . HOH   F 6 .   ? 49.17311 -24.36586 -26.86564 1.000 23.85641 ?  1008 HOH   A O   1 
HETATM 2346 O  O   . HOH   F 6 .   ? 26.61391 -31.46638 -34.12342 1.000 25.90267 ?  1009 HOH   A O   1 
HETATM 2347 O  O   . HOH   F 6 .   ? 26.36520 -21.79916 -2.40651  1.000 34.38148 ?  1010 HOH   A O   1 
HETATM 2348 O  O   . HOH   F 6 .   ? 28.84965 -44.54938 -24.38257 1.000 40.59391 ?  1011 HOH   A O   1 
HETATM 2349 O  O   . HOH   F 6 .   ? 18.57609 -41.08813 -15.88557 1.000 26.77498 ?  1012 HOH   A O   1 
HETATM 2350 O  O   . HOH   F 6 .   ? 33.19112 -4.37486  -30.57964 1.000 37.64667 ?  1013 HOH   A O   1 
HETATM 2351 O  O   . HOH   F 6 .   ? 28.33173 -12.09206 -15.74461 1.000 33.37548 ?  1014 HOH   A O   1 
HETATM 2352 O  O   . HOH   F 6 .   ? 19.91667 -28.61218 -3.50025  1.000 31.90028 ?  1015 HOH   A O   1 
HETATM 2353 O  O   . HOH   F 6 .   ? 29.81259 -34.07840 -37.95192 1.000 33.82963 ?  1016 HOH   A O   1 
HETATM 2354 O  O   . HOH   F 6 .   ? 14.49586 -17.91804 -15.16805 1.000 30.58540 ?  1017 HOH   A O   1 
HETATM 2355 O  O   . HOH   F 6 .   ? 34.49009 -16.52882 -45.91574 1.000 30.72411 ?  1018 HOH   A O   1 
HETATM 2356 O  O   . HOH   F 6 .   ? 15.07470 -14.88492 -40.46496 1.000 29.62092 ?  1019 HOH   A O   1 
HETATM 2357 O  O   . HOH   F 6 .   ? 52.04433 -25.66468 -44.21150 1.000 30.13709 ?  1020 HOH   A O   1 
HETATM 2358 O  O   . HOH   F 6 .   ? 41.80157 -10.68809 -26.39644 1.000 36.50835 ?  1021 HOH   A O   1 
HETATM 2359 O  O   . HOH   F 6 .   ? 39.79433 -28.56213 -3.85688  1.000 37.55724 ?  1022 HOH   A O   1 
HETATM 2360 O  O   . HOH   F 6 .   ? 18.63662 -22.53190 -30.36255 1.000 44.58227 ?  1023 HOH   A O   1 
HETATM 2361 O  O   . HOH   F 6 .   ? 11.93303 -19.86809 -27.75867 1.000 38.17073 ?  1024 HOH   A O   1 
HETATM 2362 O  O   . HOH   F 6 .   ? 23.21938 -3.88395  -21.73012 1.000 41.85787 ?  1025 HOH   A O   1 
# 
