data_9LSL
# 
_entry.id   9LSL 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9LSL         pdb_00009lsl 10.2210/pdb9lsl/pdb 
WWPDB D_1300056370 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-18 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9LSL 
_pdbx_database_status.recvd_initial_deposition_date   2025-02-04 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              hbluo@hainanu.edu.cn 
_pdbx_contact_author.name_first         Hai-Bin 
_pdbx_contact_author.name_last          Luo 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-2163-0509 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Wu, D.'       1 ? 
'Huang, Y.-Y.' 2 ? 
'Luo, H.-B.'   3 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   CC 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Chin.Chem.Lett. 
_citation.journal_id_ASTM           CCLEE7 
_citation.journal_id_CSD            1182 
_citation.journal_id_ISSN           1001-8417 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                111236 
_citation.page_last                 ? 
_citation.title                     
'Plasma metabolites-based drug design: Discovery of novel and highly selective phosphodiesterase 5 inhibitors' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.cclet.2025.111236 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Wu, D.'      1  ? 
primary 'Ma, Q.'      2  ? 
primary 'Chen, Y.'    3  ? 
primary 'Yang, G.'    4  ? 
primary 'Zhang, F.'   5  ? 
primary 'Jiang, M.'   6  ? 
primary 'Wang, X.'    7  ? 
primary 'Liu, X.'     8  ? 
primary 'Zhou, Q.'    9  ? 
primary 'Huang, Y.Y.' 10 ? 
primary 'Li, Z.'      11 ? 
primary 'Luo, H.B.'   12 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 
;cGMP-specific 3',5'-cyclic phosphodiesterase
;
37788.531 1  3.1.4.35 ? ? ? 
2 non-polymer syn 
;(13~{S},15~{R})-15-(3-chloranyl-4-methoxy-phenyl)-12-ethanoyl-8,12,16-triazatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(17),2,4,6,8-pentaene-4-carbonitrile
;
432.902   1  ?        ? ? ? 
3 non-polymer syn 'ZINC ION' 65.409    1  ?        ? ? ? 
4 non-polymer syn 'MAGNESIUM ION' 24.305    1  ?        ? ? ? 
5 water       nat water 18.015    39 ?        ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'cGMP-binding cGMP-specific phosphodiesterase,CGB-PDE' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;EETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHN
WRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILN
SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPI
QQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQ
ALAEQQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;EETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHN
WRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILN
SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPI
QQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQ
ALAEQQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 
;(13~{S},15~{R})-15-(3-chloranyl-4-methoxy-phenyl)-12-ethanoyl-8,12,16-triazatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(17),2,4,6,8-pentaene-4-carbonitrile
;
A1ELJ 
3 'ZINC ION' ZN    
4 'MAGNESIUM ION' MG    
5 water HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLU n 
1 2   GLU n 
1 3   THR n 
1 4   ARG n 
1 5   GLU n 
1 6   LEU n 
1 7   GLN n 
1 8   SER n 
1 9   LEU n 
1 10  ALA n 
1 11  ALA n 
1 12  ALA n 
1 13  VAL n 
1 14  VAL n 
1 15  PRO n 
1 16  SER n 
1 17  ALA n 
1 18  GLN n 
1 19  THR n 
1 20  LEU n 
1 21  LYS n 
1 22  ILE n 
1 23  THR n 
1 24  ASP n 
1 25  PHE n 
1 26  SER n 
1 27  PHE n 
1 28  SER n 
1 29  ASP n 
1 30  PHE n 
1 31  GLU n 
1 32  LEU n 
1 33  SER n 
1 34  ASP n 
1 35  LEU n 
1 36  GLU n 
1 37  THR n 
1 38  ALA n 
1 39  LEU n 
1 40  CYS n 
1 41  THR n 
1 42  ILE n 
1 43  ARG n 
1 44  MET n 
1 45  PHE n 
1 46  THR n 
1 47  ASP n 
1 48  LEU n 
1 49  ASN n 
1 50  LEU n 
1 51  VAL n 
1 52  GLN n 
1 53  ASN n 
1 54  PHE n 
1 55  GLN n 
1 56  MET n 
1 57  LYS n 
1 58  HIS n 
1 59  GLU n 
1 60  VAL n 
1 61  LEU n 
1 62  CYS n 
1 63  ARG n 
1 64  TRP n 
1 65  ILE n 
1 66  LEU n 
1 67  SER n 
1 68  VAL n 
1 69  LYS n 
1 70  LYS n 
1 71  ASN n 
1 72  TYR n 
1 73  ARG n 
1 74  LYS n 
1 75  ASN n 
1 76  VAL n 
1 77  ALA n 
1 78  TYR n 
1 79  HIS n 
1 80  ASN n 
1 81  TRP n 
1 82  ARG n 
1 83  HIS n 
1 84  ALA n 
1 85  PHE n 
1 86  ASN n 
1 87  THR n 
1 88  ALA n 
1 89  GLN n 
1 90  CYS n 
1 91  MET n 
1 92  PHE n 
1 93  ALA n 
1 94  ALA n 
1 95  LEU n 
1 96  LYS n 
1 97  ALA n 
1 98  GLY n 
1 99  LYS n 
1 100 ILE n 
1 101 GLN n 
1 102 ASN n 
1 103 LYS n 
1 104 LEU n 
1 105 THR n 
1 106 ASP n 
1 107 LEU n 
1 108 GLU n 
1 109 ILE n 
1 110 LEU n 
1 111 ALA n 
1 112 LEU n 
1 113 LEU n 
1 114 ILE n 
1 115 ALA n 
1 116 ALA n 
1 117 LEU n 
1 118 SER n 
1 119 HIS n 
1 120 ASP n 
1 121 LEU n 
1 122 ASP n 
1 123 HIS n 
1 124 ARG n 
1 125 GLY n 
1 126 VAL n 
1 127 ASN n 
1 128 ASN n 
1 129 SER n 
1 130 TYR n 
1 131 ILE n 
1 132 GLN n 
1 133 ARG n 
1 134 SER n 
1 135 GLU n 
1 136 HIS n 
1 137 PRO n 
1 138 LEU n 
1 139 ALA n 
1 140 GLN n 
1 141 LEU n 
1 142 TYR n 
1 143 CYS n 
1 144 HIS n 
1 145 SER n 
1 146 ILE n 
1 147 MET n 
1 148 GLU n 
1 149 HIS n 
1 150 HIS n 
1 151 HIS n 
1 152 PHE n 
1 153 ASP n 
1 154 GLN n 
1 155 CYS n 
1 156 LEU n 
1 157 MET n 
1 158 ILE n 
1 159 LEU n 
1 160 ASN n 
1 161 SER n 
1 162 PRO n 
1 163 GLY n 
1 164 ASN n 
1 165 GLN n 
1 166 ILE n 
1 167 LEU n 
1 168 SER n 
1 169 GLY n 
1 170 LEU n 
1 171 SER n 
1 172 ILE n 
1 173 GLU n 
1 174 GLU n 
1 175 TYR n 
1 176 LYS n 
1 177 THR n 
1 178 THR n 
1 179 LEU n 
1 180 LYS n 
1 181 ILE n 
1 182 ILE n 
1 183 LYS n 
1 184 GLN n 
1 185 ALA n 
1 186 ILE n 
1 187 LEU n 
1 188 ALA n 
1 189 THR n 
1 190 ASP n 
1 191 LEU n 
1 192 ALA n 
1 193 LEU n 
1 194 TYR n 
1 195 ILE n 
1 196 LYS n 
1 197 ARG n 
1 198 ARG n 
1 199 GLY n 
1 200 GLU n 
1 201 PHE n 
1 202 PHE n 
1 203 GLU n 
1 204 LEU n 
1 205 ILE n 
1 206 ARG n 
1 207 LYS n 
1 208 ASN n 
1 209 GLN n 
1 210 PHE n 
1 211 ASN n 
1 212 LEU n 
1 213 GLU n 
1 214 ASP n 
1 215 PRO n 
1 216 HIS n 
1 217 GLN n 
1 218 LYS n 
1 219 GLU n 
1 220 LEU n 
1 221 PHE n 
1 222 LEU n 
1 223 ALA n 
1 224 MET n 
1 225 LEU n 
1 226 MET n 
1 227 THR n 
1 228 ALA n 
1 229 CYS n 
1 230 ASP n 
1 231 LEU n 
1 232 SER n 
1 233 ALA n 
1 234 ILE n 
1 235 THR n 
1 236 LYS n 
1 237 PRO n 
1 238 TRP n 
1 239 PRO n 
1 240 ILE n 
1 241 GLN n 
1 242 GLN n 
1 243 ARG n 
1 244 ILE n 
1 245 ALA n 
1 246 GLU n 
1 247 LEU n 
1 248 VAL n 
1 249 ALA n 
1 250 THR n 
1 251 GLU n 
1 252 PHE n 
1 253 PHE n 
1 254 ASP n 
1 255 GLN n 
1 256 GLY n 
1 257 ASP n 
1 258 ARG n 
1 259 GLU n 
1 260 ARG n 
1 261 LYS n 
1 262 GLU n 
1 263 LEU n 
1 264 ASN n 
1 265 ILE n 
1 266 GLU n 
1 267 PRO n 
1 268 THR n 
1 269 ASP n 
1 270 LEU n 
1 271 MET n 
1 272 ASN n 
1 273 ARG n 
1 274 GLU n 
1 275 LYS n 
1 276 LYS n 
1 277 ASN n 
1 278 LYS n 
1 279 ILE n 
1 280 PRO n 
1 281 SER n 
1 282 MET n 
1 283 GLN n 
1 284 VAL n 
1 285 GLY n 
1 286 PHE n 
1 287 ILE n 
1 288 ASP n 
1 289 ALA n 
1 290 ILE n 
1 291 CYS n 
1 292 LEU n 
1 293 GLN n 
1 294 LEU n 
1 295 TYR n 
1 296 GLU n 
1 297 ALA n 
1 298 LEU n 
1 299 THR n 
1 300 HIS n 
1 301 VAL n 
1 302 SER n 
1 303 GLU n 
1 304 ASP n 
1 305 CYS n 
1 306 PHE n 
1 307 PRO n 
1 308 LEU n 
1 309 LEU n 
1 310 ASP n 
1 311 GLY n 
1 312 CYS n 
1 313 ARG n 
1 314 LYS n 
1 315 ASN n 
1 316 ARG n 
1 317 GLN n 
1 318 LYS n 
1 319 TRP n 
1 320 GLN n 
1 321 ALA n 
1 322 LEU n 
1 323 ALA n 
1 324 GLU n 
1 325 GLN n 
1 326 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   326 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'PDE5A, PDE5' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     511693 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1ELJ non-polymer         . 
;(13~{S},15~{R})-15-(3-chloranyl-4-methoxy-phenyl)-12-ethanoyl-8,12,16-triazatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(17),2,4,6,8-pentaene-4-carbonitrile
;
? 'C24 H21 Cl N4 O2' 432.902 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'       89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'   175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'      132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'       133.103 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'     121.158 
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'     146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'       147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'       75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'   156.162 
HOH   non-polymer         . WATER ? 'H2 O'             18.015  
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'      131.173 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'      131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'   147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'    149.211 
MG    non-polymer         . 'MAGNESIUM ION' ? 'Mg 2'             24.305  
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'      165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'       115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'       105.093 
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'       119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'    204.225 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'      181.189 
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'      117.146 
ZN    non-polymer         . 'ZINC ION' ? 'Zn 2'             65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLU 1   535 ?   ?   ?   A . n 
A 1 2   GLU 2   536 ?   ?   ?   A . n 
A 1 3   THR 3   537 537 THR THR A . n 
A 1 4   ARG 4   538 538 ARG ARG A . n 
A 1 5   GLU 5   539 539 GLU GLU A . n 
A 1 6   LEU 6   540 540 LEU LEU A . n 
A 1 7   GLN 7   541 541 GLN GLN A . n 
A 1 8   SER 8   542 542 SER SER A . n 
A 1 9   LEU 9   543 543 LEU LEU A . n 
A 1 10  ALA 10  544 544 ALA ALA A . n 
A 1 11  ALA 11  545 545 ALA ALA A . n 
A 1 12  ALA 12  546 546 ALA ALA A . n 
A 1 13  VAL 13  547 547 VAL VAL A . n 
A 1 14  VAL 14  548 548 VAL VAL A . n 
A 1 15  PRO 15  549 549 PRO PRO A . n 
A 1 16  SER 16  550 550 SER SER A . n 
A 1 17  ALA 17  551 551 ALA ALA A . n 
A 1 18  GLN 18  552 552 GLN GLN A . n 
A 1 19  THR 19  553 553 THR THR A . n 
A 1 20  LEU 20  554 554 LEU LEU A . n 
A 1 21  LYS 21  555 555 LYS LYS A . n 
A 1 22  ILE 22  556 556 ILE ILE A . n 
A 1 23  THR 23  557 557 THR THR A . n 
A 1 24  ASP 24  558 558 ASP ASP A . n 
A 1 25  PHE 25  559 559 PHE PHE A . n 
A 1 26  SER 26  560 560 SER SER A . n 
A 1 27  PHE 27  561 561 PHE PHE A . n 
A 1 28  SER 28  562 562 SER SER A . n 
A 1 29  ASP 29  563 563 ASP ASP A . n 
A 1 30  PHE 30  564 564 PHE PHE A . n 
A 1 31  GLU 31  565 565 GLU GLU A . n 
A 1 32  LEU 32  566 566 LEU LEU A . n 
A 1 33  SER 33  567 567 SER SER A . n 
A 1 34  ASP 34  568 568 ASP ASP A . n 
A 1 35  LEU 35  569 569 LEU LEU A . n 
A 1 36  GLU 36  570 570 GLU GLU A . n 
A 1 37  THR 37  571 571 THR THR A . n 
A 1 38  ALA 38  572 572 ALA ALA A . n 
A 1 39  LEU 39  573 573 LEU LEU A . n 
A 1 40  CYS 40  574 574 CYS CYS A . n 
A 1 41  THR 41  575 575 THR THR A . n 
A 1 42  ILE 42  576 576 ILE ILE A . n 
A 1 43  ARG 43  577 577 ARG ARG A . n 
A 1 44  MET 44  578 578 MET MET A . n 
A 1 45  PHE 45  579 579 PHE PHE A . n 
A 1 46  THR 46  580 580 THR THR A . n 
A 1 47  ASP 47  581 581 ASP ASP A . n 
A 1 48  LEU 48  582 582 LEU LEU A . n 
A 1 49  ASN 49  583 583 ASN ASN A . n 
A 1 50  LEU 50  584 584 LEU LEU A . n 
A 1 51  VAL 51  585 585 VAL VAL A . n 
A 1 52  GLN 52  586 586 GLN GLN A . n 
A 1 53  ASN 53  587 587 ASN ASN A . n 
A 1 54  PHE 54  588 588 PHE PHE A . n 
A 1 55  GLN 55  589 589 GLN GLN A . n 
A 1 56  MET 56  590 590 MET MET A . n 
A 1 57  LYS 57  591 591 LYS LYS A . n 
A 1 58  HIS 58  592 592 HIS HIS A . n 
A 1 59  GLU 59  593 593 GLU GLU A . n 
A 1 60  VAL 60  594 594 VAL VAL A . n 
A 1 61  LEU 61  595 595 LEU LEU A . n 
A 1 62  CYS 62  596 596 CYS CYS A . n 
A 1 63  ARG 63  597 597 ARG ARG A . n 
A 1 64  TRP 64  598 598 TRP TRP A . n 
A 1 65  ILE 65  599 599 ILE ILE A . n 
A 1 66  LEU 66  600 600 LEU LEU A . n 
A 1 67  SER 67  601 601 SER SER A . n 
A 1 68  VAL 68  602 602 VAL VAL A . n 
A 1 69  LYS 69  603 603 LYS LYS A . n 
A 1 70  LYS 70  604 604 LYS LYS A . n 
A 1 71  ASN 71  605 605 ASN ASN A . n 
A 1 72  TYR 72  606 606 TYR TYR A . n 
A 1 73  ARG 73  607 607 ARG ARG A . n 
A 1 74  LYS 74  608 608 LYS LYS A . n 
A 1 75  ASN 75  609 609 ASN ASN A . n 
A 1 76  VAL 76  610 610 VAL VAL A . n 
A 1 77  ALA 77  611 611 ALA ALA A . n 
A 1 78  TYR 78  612 612 TYR TYR A . n 
A 1 79  HIS 79  613 613 HIS HIS A . n 
A 1 80  ASN 80  614 614 ASN ASN A . n 
A 1 81  TRP 81  615 615 TRP TRP A . n 
A 1 82  ARG 82  616 616 ARG ARG A . n 
A 1 83  HIS 83  617 617 HIS HIS A . n 
A 1 84  ALA 84  618 618 ALA ALA A . n 
A 1 85  PHE 85  619 619 PHE PHE A . n 
A 1 86  ASN 86  620 620 ASN ASN A . n 
A 1 87  THR 87  621 621 THR THR A . n 
A 1 88  ALA 88  622 622 ALA ALA A . n 
A 1 89  GLN 89  623 623 GLN GLN A . n 
A 1 90  CYS 90  624 624 CYS CYS A . n 
A 1 91  MET 91  625 625 MET MET A . n 
A 1 92  PHE 92  626 626 PHE PHE A . n 
A 1 93  ALA 93  627 627 ALA ALA A . n 
A 1 94  ALA 94  628 628 ALA ALA A . n 
A 1 95  LEU 95  629 629 LEU LEU A . n 
A 1 96  LYS 96  630 630 LYS LYS A . n 
A 1 97  ALA 97  631 631 ALA ALA A . n 
A 1 98  GLY 98  632 632 GLY GLY A . n 
A 1 99  LYS 99  633 633 LYS LYS A . n 
A 1 100 ILE 100 634 634 ILE ILE A . n 
A 1 101 GLN 101 635 635 GLN GLN A . n 
A 1 102 ASN 102 636 636 ASN ASN A . n 
A 1 103 LYS 103 637 637 LYS LYS A . n 
A 1 104 LEU 104 638 638 LEU LEU A . n 
A 1 105 THR 105 639 639 THR THR A . n 
A 1 106 ASP 106 640 640 ASP ASP A . n 
A 1 107 LEU 107 641 641 LEU LEU A . n 
A 1 108 GLU 108 642 642 GLU GLU A . n 
A 1 109 ILE 109 643 643 ILE ILE A . n 
A 1 110 LEU 110 644 644 LEU LEU A . n 
A 1 111 ALA 111 645 645 ALA ALA A . n 
A 1 112 LEU 112 646 646 LEU LEU A . n 
A 1 113 LEU 113 647 647 LEU LEU A . n 
A 1 114 ILE 114 648 648 ILE ILE A . n 
A 1 115 ALA 115 649 649 ALA ALA A . n 
A 1 116 ALA 116 650 650 ALA ALA A . n 
A 1 117 LEU 117 651 651 LEU LEU A . n 
A 1 118 SER 118 652 652 SER SER A . n 
A 1 119 HIS 119 653 653 HIS HIS A . n 
A 1 120 ASP 120 654 654 ASP ASP A . n 
A 1 121 LEU 121 655 655 LEU LEU A . n 
A 1 122 ASP 122 656 656 ASP ASP A . n 
A 1 123 HIS 123 657 657 HIS HIS A . n 
A 1 124 ARG 124 658 658 ARG ARG A . n 
A 1 125 GLY 125 659 659 GLY GLY A . n 
A 1 126 VAL 126 660 660 VAL VAL A . n 
A 1 127 ASN 127 661 661 ASN ASN A . n 
A 1 128 ASN 128 662 662 ASN ASN A . n 
A 1 129 SER 129 663 ?   ?   ?   A . n 
A 1 130 TYR 130 664 ?   ?   ?   A . n 
A 1 131 ILE 131 665 ?   ?   ?   A . n 
A 1 132 GLN 132 666 ?   ?   ?   A . n 
A 1 133 ARG 133 667 ?   ?   ?   A . n 
A 1 134 SER 134 668 ?   ?   ?   A . n 
A 1 135 GLU 135 669 ?   ?   ?   A . n 
A 1 136 HIS 136 670 ?   ?   ?   A . n 
A 1 137 PRO 137 671 ?   ?   ?   A . n 
A 1 138 LEU 138 672 ?   ?   ?   A . n 
A 1 139 ALA 139 673 ?   ?   ?   A . n 
A 1 140 GLN 140 674 ?   ?   ?   A . n 
A 1 141 LEU 141 675 ?   ?   ?   A . n 
A 1 142 TYR 142 676 ?   ?   ?   A . n 
A 1 143 CYS 143 677 ?   ?   ?   A . n 
A 1 144 HIS 144 678 ?   ?   ?   A . n 
A 1 145 SER 145 679 679 SER SER A . n 
A 1 146 ILE 146 680 680 ILE ILE A . n 
A 1 147 MET 147 681 681 MET MET A . n 
A 1 148 GLU 148 682 682 GLU GLU A . n 
A 1 149 HIS 149 683 683 HIS HIS A . n 
A 1 150 HIS 150 684 684 HIS HIS A . n 
A 1 151 HIS 151 685 685 HIS HIS A . n 
A 1 152 PHE 152 686 686 PHE PHE A . n 
A 1 153 ASP 153 687 687 ASP ASP A . n 
A 1 154 GLN 154 688 688 GLN GLN A . n 
A 1 155 CYS 155 689 689 CYS CYS A . n 
A 1 156 LEU 156 690 690 LEU LEU A . n 
A 1 157 MET 157 691 691 MET MET A . n 
A 1 158 ILE 158 692 692 ILE ILE A . n 
A 1 159 LEU 159 693 693 LEU LEU A . n 
A 1 160 ASN 160 694 694 ASN ASN A . n 
A 1 161 SER 161 695 695 SER SER A . n 
A 1 162 PRO 162 696 696 PRO PRO A . n 
A 1 163 GLY 163 697 697 GLY GLY A . n 
A 1 164 ASN 164 698 698 ASN ASN A . n 
A 1 165 GLN 165 699 699 GLN GLN A . n 
A 1 166 ILE 166 700 700 ILE ILE A . n 
A 1 167 LEU 167 701 701 LEU LEU A . n 
A 1 168 SER 168 702 702 SER SER A . n 
A 1 169 GLY 169 703 703 GLY GLY A . n 
A 1 170 LEU 170 704 704 LEU LEU A . n 
A 1 171 SER 171 705 705 SER SER A . n 
A 1 172 ILE 172 706 706 ILE ILE A . n 
A 1 173 GLU 173 707 707 GLU GLU A . n 
A 1 174 GLU 174 708 708 GLU GLU A . n 
A 1 175 TYR 175 709 709 TYR TYR A . n 
A 1 176 LYS 176 710 710 LYS LYS A . n 
A 1 177 THR 177 711 711 THR THR A . n 
A 1 178 THR 178 712 712 THR THR A . n 
A 1 179 LEU 179 713 713 LEU LEU A . n 
A 1 180 LYS 180 714 714 LYS LYS A . n 
A 1 181 ILE 181 715 715 ILE ILE A . n 
A 1 182 ILE 182 716 716 ILE ILE A . n 
A 1 183 LYS 183 717 717 LYS LYS A . n 
A 1 184 GLN 184 718 718 GLN GLN A . n 
A 1 185 ALA 185 719 719 ALA ALA A . n 
A 1 186 ILE 186 720 720 ILE ILE A . n 
A 1 187 LEU 187 721 721 LEU LEU A . n 
A 1 188 ALA 188 722 722 ALA ALA A . n 
A 1 189 THR 189 723 723 THR THR A . n 
A 1 190 ASP 190 724 724 ASP ASP A . n 
A 1 191 LEU 191 725 725 LEU LEU A . n 
A 1 192 ALA 192 726 726 ALA ALA A . n 
A 1 193 LEU 193 727 727 LEU LEU A . n 
A 1 194 TYR 194 728 728 TYR TYR A . n 
A 1 195 ILE 195 729 729 ILE ILE A . n 
A 1 196 LYS 196 730 730 LYS LYS A . n 
A 1 197 ARG 197 731 731 ARG ARG A . n 
A 1 198 ARG 198 732 732 ARG ARG A . n 
A 1 199 GLY 199 733 733 GLY GLY A . n 
A 1 200 GLU 200 734 734 GLU GLU A . n 
A 1 201 PHE 201 735 735 PHE PHE A . n 
A 1 202 PHE 202 736 736 PHE PHE A . n 
A 1 203 GLU 203 737 737 GLU GLU A . n 
A 1 204 LEU 204 738 738 LEU LEU A . n 
A 1 205 ILE 205 739 739 ILE ILE A . n 
A 1 206 ARG 206 740 740 ARG ARG A . n 
A 1 207 LYS 207 741 741 LYS LYS A . n 
A 1 208 ASN 208 742 742 ASN ASN A . n 
A 1 209 GLN 209 743 743 GLN GLN A . n 
A 1 210 PHE 210 744 744 PHE PHE A . n 
A 1 211 ASN 211 745 745 ASN ASN A . n 
A 1 212 LEU 212 746 746 LEU LEU A . n 
A 1 213 GLU 213 747 747 GLU GLU A . n 
A 1 214 ASP 214 748 748 ASP ASP A . n 
A 1 215 PRO 215 749 749 PRO PRO A . n 
A 1 216 HIS 216 750 750 HIS HIS A . n 
A 1 217 GLN 217 751 751 GLN GLN A . n 
A 1 218 LYS 218 752 752 LYS LYS A . n 
A 1 219 GLU 219 753 753 GLU GLU A . n 
A 1 220 LEU 220 754 754 LEU LEU A . n 
A 1 221 PHE 221 755 755 PHE PHE A . n 
A 1 222 LEU 222 756 756 LEU LEU A . n 
A 1 223 ALA 223 757 757 ALA ALA A . n 
A 1 224 MET 224 758 758 MET MET A . n 
A 1 225 LEU 225 759 759 LEU LEU A . n 
A 1 226 MET 226 760 760 MET MET A . n 
A 1 227 THR 227 761 761 THR THR A . n 
A 1 228 ALA 228 762 762 ALA ALA A . n 
A 1 229 CYS 229 763 763 CYS CYS A . n 
A 1 230 ASP 230 764 764 ASP ASP A . n 
A 1 231 LEU 231 765 765 LEU LEU A . n 
A 1 232 SER 232 766 766 SER SER A . n 
A 1 233 ALA 233 767 767 ALA ALA A . n 
A 1 234 ILE 234 768 768 ILE ILE A . n 
A 1 235 THR 235 769 769 THR THR A . n 
A 1 236 LYS 236 770 770 LYS LYS A . n 
A 1 237 PRO 237 771 771 PRO PRO A . n 
A 1 238 TRP 238 772 772 TRP TRP A . n 
A 1 239 PRO 239 773 773 PRO PRO A . n 
A 1 240 ILE 240 774 774 ILE ILE A . n 
A 1 241 GLN 241 775 775 GLN GLN A . n 
A 1 242 GLN 242 776 776 GLN GLN A . n 
A 1 243 ARG 243 777 777 ARG ARG A . n 
A 1 244 ILE 244 778 778 ILE ILE A . n 
A 1 245 ALA 245 779 779 ALA ALA A . n 
A 1 246 GLU 246 780 780 GLU GLU A . n 
A 1 247 LEU 247 781 781 LEU LEU A . n 
A 1 248 VAL 248 782 782 VAL VAL A . n 
A 1 249 ALA 249 783 783 ALA ALA A . n 
A 1 250 THR 250 784 784 THR THR A . n 
A 1 251 GLU 251 785 785 GLU GLU A . n 
A 1 252 PHE 252 786 786 PHE PHE A . n 
A 1 253 PHE 253 787 787 PHE PHE A . n 
A 1 254 ASP 254 788 788 ASP ASP A . n 
A 1 255 GLN 255 789 789 GLN GLN A . n 
A 1 256 GLY 256 790 790 GLY GLY A . n 
A 1 257 ASP 257 791 ?   ?   ?   A . n 
A 1 258 ARG 258 792 ?   ?   ?   A . n 
A 1 259 GLU 259 793 ?   ?   ?   A . n 
A 1 260 ARG 260 794 ?   ?   ?   A . n 
A 1 261 LYS 261 795 ?   ?   ?   A . n 
A 1 262 GLU 262 796 ?   ?   ?   A . n 
A 1 263 LEU 263 797 ?   ?   ?   A . n 
A 1 264 ASN 264 798 ?   ?   ?   A . n 
A 1 265 ILE 265 799 ?   ?   ?   A . n 
A 1 266 GLU 266 800 ?   ?   ?   A . n 
A 1 267 PRO 267 801 ?   ?   ?   A . n 
A 1 268 THR 268 802 ?   ?   ?   A . n 
A 1 269 ASP 269 803 ?   ?   ?   A . n 
A 1 270 LEU 270 804 ?   ?   ?   A . n 
A 1 271 MET 271 805 ?   ?   ?   A . n 
A 1 272 ASN 272 806 ?   ?   ?   A . n 
A 1 273 ARG 273 807 ?   ?   ?   A . n 
A 1 274 GLU 274 808 ?   ?   ?   A . n 
A 1 275 LYS 275 809 ?   ?   ?   A . n 
A 1 276 LYS 276 810 ?   ?   ?   A . n 
A 1 277 ASN 277 811 811 ASN ASN A . n 
A 1 278 LYS 278 812 812 LYS LYS A . n 
A 1 279 ILE 279 813 813 ILE ILE A . n 
A 1 280 PRO 280 814 814 PRO PRO A . n 
A 1 281 SER 281 815 815 SER SER A . n 
A 1 282 MET 282 816 816 MET MET A . n 
A 1 283 GLN 283 817 817 GLN GLN A . n 
A 1 284 VAL 284 818 818 VAL VAL A . n 
A 1 285 GLY 285 819 819 GLY GLY A . n 
A 1 286 PHE 286 820 820 PHE PHE A . n 
A 1 287 ILE 287 821 821 ILE ILE A . n 
A 1 288 ASP 288 822 822 ASP ASP A . n 
A 1 289 ALA 289 823 823 ALA ALA A . n 
A 1 290 ILE 290 824 824 ILE ILE A . n 
A 1 291 CYS 291 825 825 CYS CYS A . n 
A 1 292 LEU 292 826 826 LEU LEU A . n 
A 1 293 GLN 293 827 827 GLN GLN A . n 
A 1 294 LEU 294 828 828 LEU LEU A . n 
A 1 295 TYR 295 829 829 TYR TYR A . n 
A 1 296 GLU 296 830 830 GLU GLU A . n 
A 1 297 ALA 297 831 831 ALA ALA A . n 
A 1 298 LEU 298 832 832 LEU LEU A . n 
A 1 299 THR 299 833 833 THR THR A . n 
A 1 300 HIS 300 834 834 HIS HIS A . n 
A 1 301 VAL 301 835 835 VAL VAL A . n 
A 1 302 SER 302 836 836 SER SER A . n 
A 1 303 GLU 303 837 837 GLU GLU A . n 
A 1 304 ASP 304 838 838 ASP ASP A . n 
A 1 305 CYS 305 839 839 CYS CYS A . n 
A 1 306 PHE 306 840 840 PHE PHE A . n 
A 1 307 PRO 307 841 841 PRO PRO A . n 
A 1 308 LEU 308 842 842 LEU LEU A . n 
A 1 309 LEU 309 843 843 LEU LEU A . n 
A 1 310 ASP 310 844 844 ASP ASP A . n 
A 1 311 GLY 311 845 845 GLY GLY A . n 
A 1 312 CYS 312 846 846 CYS CYS A . n 
A 1 313 ARG 313 847 847 ARG ARG A . n 
A 1 314 LYS 314 848 848 LYS LYS A . n 
A 1 315 ASN 315 849 849 ASN ASN A . n 
A 1 316 ARG 316 850 850 ARG ARG A . n 
A 1 317 GLN 317 851 851 GLN GLN A . n 
A 1 318 LYS 318 852 852 LYS LYS A . n 
A 1 319 TRP 319 853 853 TRP TRP A . n 
A 1 320 GLN 320 854 854 GLN GLN A . n 
A 1 321 ALA 321 855 855 ALA ALA A . n 
A 1 322 LEU 322 856 856 LEU LEU A . n 
A 1 323 ALA 323 857 857 ALA ALA A . n 
A 1 324 GLU 324 858 858 GLU GLU A . n 
A 1 325 GLN 325 859 859 GLN GLN A . n 
A 1 326 GLN 326 860 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1ELJ 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1ELJ 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 A1ELJ 1  901  901 A1ELJ YQ2 A . 
C 3 ZN    1  902  1   ZN    ZN  A . 
D 4 MG    1  903  1   MG    MG  A . 
E 5 HOH   1  1001 1   HOH   HOH A . 
E 5 HOH   2  1002 37  HOH   HOH A . 
E 5 HOH   3  1003 36  HOH   HOH A . 
E 5 HOH   4  1004 27  HOH   HOH A . 
E 5 HOH   5  1005 2   HOH   HOH A . 
E 5 HOH   6  1006 5   HOH   HOH A . 
E 5 HOH   7  1007 41  HOH   HOH A . 
E 5 HOH   8  1008 19  HOH   HOH A . 
E 5 HOH   9  1009 14  HOH   HOH A . 
E 5 HOH   10 1010 17  HOH   HOH A . 
E 5 HOH   11 1011 4   HOH   HOH A . 
E 5 HOH   12 1012 13  HOH   HOH A . 
E 5 HOH   13 1013 43  HOH   HOH A . 
E 5 HOH   14 1014 20  HOH   HOH A . 
E 5 HOH   15 1015 3   HOH   HOH A . 
E 5 HOH   16 1016 35  HOH   HOH A . 
E 5 HOH   17 1017 7   HOH   HOH A . 
E 5 HOH   18 1018 25  HOH   HOH A . 
E 5 HOH   19 1019 11  HOH   HOH A . 
E 5 HOH   20 1020 40  HOH   HOH A . 
E 5 HOH   21 1021 23  HOH   HOH A . 
E 5 HOH   22 1022 10  HOH   HOH A . 
E 5 HOH   23 1023 18  HOH   HOH A . 
E 5 HOH   24 1024 6   HOH   HOH A . 
E 5 HOH   25 1025 39  HOH   HOH A . 
E 5 HOH   26 1026 30  HOH   HOH A . 
E 5 HOH   27 1027 28  HOH   HOH A . 
E 5 HOH   28 1028 9   HOH   HOH A . 
E 5 HOH   29 1029 31  HOH   HOH A . 
E 5 HOH   30 1030 12  HOH   HOH A . 
E 5 HOH   31 1031 24  HOH   HOH A . 
E 5 HOH   32 1032 22  HOH   HOH A . 
E 5 HOH   33 1033 21  HOH   HOH A . 
E 5 HOH   34 1034 26  HOH   HOH A . 
E 5 HOH   35 1035 34  HOH   HOH A . 
E 5 HOH   36 1036 33  HOH   HOH A . 
E 5 HOH   37 1037 8   HOH   HOH A . 
E 5 HOH   38 1038 15  HOH   HOH A . 
E 5 HOH   39 1039 44  HOH   HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC      ? ? ? V1.0        1 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX      ? ? ? 1.20.1_4487 2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? CrysalisPro ? ? ? V2.0        3 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9LSL 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     74.419 
_cell.length_a_esd                 ? 
_cell.length_b                     74.419 
_cell.length_b_esd                 ? 
_cell.length_c                     132.052 
_cell.length_c_esd                 ? 
_cell.volume                       633344.164 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9LSL 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                152 
_symmetry.space_group_name_Hall            
;P 31 2"
;
_symmetry.space_group_name_H-M             'P 31 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9LSL 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.79 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          55.97 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M MgSO4, 0.1 M Cacodylate sodium salt, pH 6.5, 2.5% ethanol, and 18% PEG3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            298 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'RIGAKU HyPix-3000' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-10-30 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.54184 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        RIGAKU 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.54184 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          37.56 
_reflns.entry_id                                       9LSL 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.5 
_reflns.d_resolution_low                               24.44 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     15180 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.96 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                9.2 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          13.6 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.13 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.5 
_reflns_shell.d_res_low                                     2.6 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           3.4 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             100 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               9.4 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.58 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               44.34 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9LSL 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.50 
_refine.ls_d_res_low                             24.44 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     15177 
_refine.ls_number_reflns_R_free                  803 
_refine.ls_number_reflns_R_work                  14374 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.94 
_refine.ls_percent_reflns_R_free                 5.29 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2457 
_refine.ls_R_factor_R_free                       0.2961 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2430 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.37 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 31.0861 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3406 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.50 
_refine_hist.d_res_low                        24.44 
_refine_hist.number_atoms_solvent             39 
_refine_hist.number_atoms_total               2384 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2312 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         33 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0022 ? 2390 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.5088 ? 3231 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0342 ? 366  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0043 ? 434  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 4.9342 ? 331  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.50 2.66  . . 109 2379 100.00 . . . . 0.3272 . . . . . . . . . . . 0.3742 
'X-RAY DIFFRACTION' 2.66 2.86  . . 134 2364 100.00 . . . . 0.2992 . . . . . . . . . . . 0.3574 
'X-RAY DIFFRACTION' 2.86 3.15  . . 133 2349 100.00 . . . . 0.3125 . . . . . . . . . . . 0.3843 
'X-RAY DIFFRACTION' 3.15 3.60  . . 149 2364 100.00 . . . . 0.2378 . . . . . . . . . . . 0.2954 
'X-RAY DIFFRACTION' 3.60 4.54  . . 158 2374 100.00 . . . . 0.2183 . . . . . . . . . . . 0.2500 
'X-RAY DIFFRACTION' 4.54 24.44 . . 120 2544 99.66  . . . . 0.2004 . . . . . . . . . . . 0.2657 
# 
_struct.entry_id                     9LSL 
_struct.title                        'The crystal structure of PDE5A with L1' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9LSL 
_struct_keywords.text            'PDE5A, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    PDE5A_HUMAN 
_struct_ref.pdbx_db_accession          O76074 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;EETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHN
WRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILN
SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPI
QQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQ
ALAEQQ
;
_struct_ref.pdbx_align_begin           535 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9LSL 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 326 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             O76074 
_struct_ref_seq.db_align_beg                  535 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  860 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       535 
_struct_ref_seq.pdbx_auth_seq_align_end       860 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 3   ? ALA A 12  ? THR A 537 ALA A 546 1 ? 10 
HELX_P HELX_P2  AA2 SER A 16  ? LYS A 21  ? SER A 550 LYS A 555 1 ? 6  
HELX_P HELX_P3  AA3 SER A 33  ? LEU A 48  ? SER A 567 LEU A 582 1 ? 16 
HELX_P HELX_P4  AA4 ASN A 49  ? PHE A 54  ? ASN A 583 PHE A 588 1 ? 6  
HELX_P HELX_P5  AA5 LYS A 57  ? ASN A 71  ? LYS A 591 ASN A 605 1 ? 15 
HELX_P HELX_P6  AA6 ASN A 80  ? LYS A 96  ? ASN A 614 LYS A 630 1 ? 17 
HELX_P HELX_P7  AA7 ILE A 100 ? LEU A 104 ? ILE A 634 LEU A 638 5 ? 5  
HELX_P HELX_P8  AA8 THR A 105 ? HIS A 119 ? THR A 639 HIS A 653 1 ? 15 
HELX_P HELX_P9  AA9 ILE A 146 ? ASN A 160 ? ILE A 680 ASN A 694 1 ? 15 
HELX_P HELX_P10 AB1 SER A 171 ? THR A 189 ? SER A 705 THR A 723 1 ? 19 
HELX_P HELX_P11 AB2 ASP A 190 ? LYS A 207 ? ASP A 724 LYS A 741 1 ? 18 
HELX_P HELX_P12 AB3 ASP A 214 ? LEU A 231 ? ASP A 748 LEU A 765 1 ? 18 
HELX_P HELX_P13 AB4 SER A 232 ? LYS A 236 ? SER A 766 LYS A 770 5 ? 5  
HELX_P HELX_P14 AB5 PRO A 237 ? PHE A 253 ? PRO A 771 PHE A 787 1 ? 17 
HELX_P HELX_P15 AB6 LYS A 278 ? ILE A 290 ? LYS A 812 ILE A 824 1 ? 13 
HELX_P HELX_P16 AB7 ILE A 290 ? SER A 302 ? ILE A 824 SER A 836 1 ? 13 
HELX_P HELX_P17 AB8 CYS A 305 ? GLU A 324 ? CYS A 839 GLU A 858 1 ? 20 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A HIS 83  NE2 ? ? ? 1_555 C ZN  . ZN ? ? A HIS 617 A ZN  902  1_555 ? ? ? ? ? ? ? 2.294 ? ? 
metalc2  metalc ? ? A HIS 119 NE2 ? ? ? 1_555 C ZN  . ZN ? ? A HIS 653 A ZN  902  1_555 ? ? ? ? ? ? ? 2.289 ? ? 
metalc3  metalc ? ? A ASP 120 OD2 ? ? ? 1_555 C ZN  . ZN ? ? A ASP 654 A ZN  902  1_555 ? ? ? ? ? ? ? 2.155 ? ? 
metalc4  metalc ? ? A ASP 120 OD1 ? ? ? 1_555 D MG  . MG ? ? A ASP 654 A MG  903  1_555 ? ? ? ? ? ? ? 2.475 ? ? 
metalc5  metalc ? ? A ASP 230 OD1 ? ? ? 1_555 C ZN  . ZN ? ? A ASP 764 A ZN  902  1_555 ? ? ? ? ? ? ? 2.214 ? ? 
metalc6  metalc ? ? C ZN  .   ZN  ? ? ? 1_555 E HOH . O  ? ? A ZN  902 A HOH 1006 1_555 ? ? ? ? ? ? ? 2.100 ? ? 
metalc7  metalc ? ? C ZN  .   ZN  ? ? ? 1_555 E HOH . O  ? ? A ZN  902 A HOH 1011 1_555 ? ? ? ? ? ? ? 2.522 ? ? 
metalc8  metalc ? ? D MG  .   MG  ? ? ? 1_555 E HOH . O  ? ? A MG  903 A HOH 1001 1_555 ? ? ? ? ? ? ? 2.102 ? ? 
metalc9  metalc ? ? D MG  .   MG  ? ? ? 1_555 E HOH . O  ? ? A MG  903 A HOH 1005 1_555 ? ? ? ? ? ? ? 2.174 ? ? 
metalc10 metalc ? ? D MG  .   MG  ? ? ? 1_555 E HOH . O  ? ? A MG  903 A HOH 1006 1_555 ? ? ? ? ? ? ? 2.269 ? ? 
metalc11 metalc ? ? D MG  .   MG  ? ? ? 1_555 E HOH . O  ? ? A MG  903 A HOH 1015 1_555 ? ? ? ? ? ? ? 2.207 ? ? 
metalc12 metalc ? ? D MG  .   MG  ? ? ? 1_555 E HOH . O  ? ? A MG  903 A HOH 1024 1_555 ? ? ? ? ? ? ? 2.062 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  NE2 ? A HIS 83  ? A HIS 617  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 NE2 ? A HIS 119 ? A HIS 653  ? 1_555 92.5  ? 
2  NE2 ? A HIS 83  ? A HIS 617  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 OD2 ? A ASP 120 ? A ASP 654  ? 1_555 88.7  ? 
3  NE2 ? A HIS 119 ? A HIS 653  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 OD2 ? A ASP 120 ? A ASP 654  ? 1_555 83.1  ? 
4  NE2 ? A HIS 83  ? A HIS 617  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 OD1 ? A ASP 230 ? A ASP 764  ? 1_555 93.2  ? 
5  NE2 ? A HIS 119 ? A HIS 653  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 OD1 ? A ASP 230 ? A ASP 764  ? 1_555 73.7  ? 
6  OD2 ? A ASP 120 ? A ASP 654  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 OD1 ? A ASP 230 ? A ASP 764  ? 1_555 156.7 ? 
7  NE2 ? A HIS 83  ? A HIS 617  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 O   ? E HOH .   ? A HOH 1006 ? 1_555 157.4 ? 
8  NE2 ? A HIS 119 ? A HIS 653  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 O   ? E HOH .   ? A HOH 1006 ? 1_555 106.9 ? 
9  OD2 ? A ASP 120 ? A ASP 654  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 O   ? E HOH .   ? A HOH 1006 ? 1_555 104.7 ? 
10 OD1 ? A ASP 230 ? A ASP 764  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 O   ? E HOH .   ? A HOH 1006 ? 1_555 81.7  ? 
11 NE2 ? A HIS 83  ? A HIS 617  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 O   ? E HOH .   ? A HOH 1011 ? 1_555 84.0  ? 
12 NE2 ? A HIS 119 ? A HIS 653  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 O   ? E HOH .   ? A HOH 1011 ? 1_555 171.8 ? 
13 OD2 ? A ASP 120 ? A ASP 654  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 O   ? E HOH .   ? A HOH 1011 ? 1_555 104.2 ? 
14 OD1 ? A ASP 230 ? A ASP 764  ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 O   ? E HOH .   ? A HOH 1011 ? 1_555 99.1  ? 
15 O   ? E HOH .   ? A HOH 1006 ? 1_555 ZN ? C ZN . ? A ZN 902 ? 1_555 O   ? E HOH .   ? A HOH 1011 ? 1_555 75.2  ? 
16 OD1 ? A ASP 120 ? A ASP 654  ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? E HOH .   ? A HOH 1001 ? 1_555 149.4 ? 
17 OD1 ? A ASP 120 ? A ASP 654  ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? E HOH .   ? A HOH 1005 ? 1_555 74.3  ? 
18 O   ? E HOH .   ? A HOH 1001 ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? E HOH .   ? A HOH 1005 ? 1_555 82.2  ? 
19 OD1 ? A ASP 120 ? A ASP 654  ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? E HOH .   ? A HOH 1006 ? 1_555 100.7 ? 
20 O   ? E HOH .   ? A HOH 1001 ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? E HOH .   ? A HOH 1006 ? 1_555 101.9 ? 
21 O   ? E HOH .   ? A HOH 1005 ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? E HOH .   ? A HOH 1006 ? 1_555 98.1  ? 
22 OD1 ? A ASP 120 ? A ASP 654  ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? E HOH .   ? A HOH 1015 ? 1_555 75.7  ? 
23 O   ? E HOH .   ? A HOH 1001 ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? E HOH .   ? A HOH 1015 ? 1_555 80.6  ? 
24 O   ? E HOH .   ? A HOH 1005 ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? E HOH .   ? A HOH 1015 ? 1_555 78.5  ? 
25 O   ? E HOH .   ? A HOH 1006 ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? E HOH .   ? A HOH 1015 ? 1_555 175.5 ? 
26 OD1 ? A ASP 120 ? A ASP 654  ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? E HOH .   ? A HOH 1024 ? 1_555 92.8  ? 
27 O   ? E HOH .   ? A HOH 1001 ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? E HOH .   ? A HOH 1024 ? 1_555 110.0 ? 
28 O   ? E HOH .   ? A HOH 1005 ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? E HOH .   ? A HOH 1024 ? 1_555 167.1 ? 
29 O   ? E HOH .   ? A HOH 1006 ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? E HOH .   ? A HOH 1024 ? 1_555 83.8  ? 
30 O   ? E HOH .   ? A HOH 1015 ? 1_555 MG ? D MG . ? A MG 903 ? 1_555 O   ? E HOH .   ? A HOH 1024 ? 1_555 99.0  ? 
# 
_pdbx_entry_details.entry_id                   9LSL 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 TYR A 612 ? ? -105.79 -62.64  
2 1 ASN A 614 ? ? -129.69 -167.84 
3 1 LYS A 630 ? ? -90.66  -77.67  
4 1 ASN A 661 ? ? -100.68 68.23   
5 1 LYS A 741 ? ? -66.84  8.15    
6 1 ASN A 742 ? ? 56.92   19.55   
7 1 PHE A 787 ? ? -76.26  -95.25  
8 1 ASP A 788 ? ? -66.36  26.96   
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z          
2 -y,x-y,z+1/3   
3 -x+y,-x,z+2/3  
4 x-y,-y,-z+2/3  
5 -x,-x+y,-z+1/3 
6 y,x,-z         
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLU 535 ? A GLU 1   
2  1 Y 1 A GLU 536 ? A GLU 2   
3  1 Y 1 A SER 663 ? A SER 129 
4  1 Y 1 A TYR 664 ? A TYR 130 
5  1 Y 1 A ILE 665 ? A ILE 131 
6  1 Y 1 A GLN 666 ? A GLN 132 
7  1 Y 1 A ARG 667 ? A ARG 133 
8  1 Y 1 A SER 668 ? A SER 134 
9  1 Y 1 A GLU 669 ? A GLU 135 
10 1 Y 1 A HIS 670 ? A HIS 136 
11 1 Y 1 A PRO 671 ? A PRO 137 
12 1 Y 1 A LEU 672 ? A LEU 138 
13 1 Y 1 A ALA 673 ? A ALA 139 
14 1 Y 1 A GLN 674 ? A GLN 140 
15 1 Y 1 A LEU 675 ? A LEU 141 
16 1 Y 1 A TYR 676 ? A TYR 142 
17 1 Y 1 A CYS 677 ? A CYS 143 
18 1 Y 1 A HIS 678 ? A HIS 144 
19 1 Y 1 A ASP 791 ? A ASP 257 
20 1 Y 1 A ARG 792 ? A ARG 258 
21 1 Y 1 A GLU 793 ? A GLU 259 
22 1 Y 1 A ARG 794 ? A ARG 260 
23 1 Y 1 A LYS 795 ? A LYS 261 
24 1 Y 1 A GLU 796 ? A GLU 262 
25 1 Y 1 A LEU 797 ? A LEU 263 
26 1 Y 1 A ASN 798 ? A ASN 264 
27 1 Y 1 A ILE 799 ? A ILE 265 
28 1 Y 1 A GLU 800 ? A GLU 266 
29 1 Y 1 A PRO 801 ? A PRO 267 
30 1 Y 1 A THR 802 ? A THR 268 
31 1 Y 1 A ASP 803 ? A ASP 269 
32 1 Y 1 A LEU 804 ? A LEU 270 
33 1 Y 1 A MET 805 ? A MET 271 
34 1 Y 1 A ASN 806 ? A ASN 272 
35 1 Y 1 A ARG 807 ? A ARG 273 
36 1 Y 1 A GLU 808 ? A GLU 274 
37 1 Y 1 A LYS 809 ? A LYS 275 
38 1 Y 1 A LYS 810 ? A LYS 276 
39 1 Y 1 A GLN 860 ? A GLN 326 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1ELJ C13  C  Y N 1   
A1ELJ C15  C  N N 2   
A1ELJ C17  C  Y N 3   
A1ELJ C20  C  Y N 4   
A1ELJ C22  C  Y N 5   
A1ELJ C11  C  Y N 6   
A1ELJ C12  C  Y N 7   
A1ELJ C18  C  Y N 8   
A1ELJ C19  C  Y N 9   
A1ELJ C23  C  Y N 10  
A1ELJ C1   C  N N 11  
A1ELJ C10  C  Y N 12  
A1ELJ C14  C  N S 13  
A1ELJ C16  C  N R 14  
A1ELJ C2   C  N N 15  
A1ELJ C21  C  N N 16  
A1ELJ C3   C  N N 17  
A1ELJ C4   C  Y N 18  
A1ELJ C5   C  Y N 19  
A1ELJ C6   C  Y N 20  
A1ELJ C7   C  Y N 21  
A1ELJ C8   C  Y N 22  
A1ELJ C9   C  N N 23  
A1ELJ N1   N  Y N 24  
A1ELJ N2   N  N N 25  
A1ELJ N3   N  N N 26  
A1ELJ O1   O  N N 27  
A1ELJ N    N  N N 28  
A1ELJ C    C  N N 29  
A1ELJ O    O  N N 30  
A1ELJ CL   CL N N 31  
A1ELJ H11  H  N N 32  
A1ELJ H12  H  N N 33  
A1ELJ H14  H  N N 34  
A1ELJ H15  H  N N 35  
A1ELJ H19  H  N N 36  
A1ELJ H9   H  N N 37  
A1ELJ H10  H  N N 38  
A1ELJ H13  H  N N 39  
A1ELJ H4   H  N N 40  
A1ELJ H3   H  N N 41  
A1ELJ H18  H  N N 42  
A1ELJ H17  H  N N 43  
A1ELJ H16  H  N N 44  
A1ELJ H6   H  N N 45  
A1ELJ H5   H  N N 46  
A1ELJ H7   H  N N 47  
A1ELJ H8   H  N N 48  
A1ELJ H20  H  N N 49  
A1ELJ H    H  N N 50  
A1ELJ H1   H  N N 51  
A1ELJ H2   H  N N 52  
ALA   N    N  N N 53  
ALA   CA   C  N S 54  
ALA   C    C  N N 55  
ALA   O    O  N N 56  
ALA   CB   C  N N 57  
ALA   OXT  O  N N 58  
ALA   H    H  N N 59  
ALA   H2   H  N N 60  
ALA   HA   H  N N 61  
ALA   HB1  H  N N 62  
ALA   HB2  H  N N 63  
ALA   HB3  H  N N 64  
ALA   HXT  H  N N 65  
ARG   N    N  N N 66  
ARG   CA   C  N S 67  
ARG   C    C  N N 68  
ARG   O    O  N N 69  
ARG   CB   C  N N 70  
ARG   CG   C  N N 71  
ARG   CD   C  N N 72  
ARG   NE   N  N N 73  
ARG   CZ   C  N N 74  
ARG   NH1  N  N N 75  
ARG   NH2  N  N N 76  
ARG   OXT  O  N N 77  
ARG   H    H  N N 78  
ARG   H2   H  N N 79  
ARG   HA   H  N N 80  
ARG   HB2  H  N N 81  
ARG   HB3  H  N N 82  
ARG   HG2  H  N N 83  
ARG   HG3  H  N N 84  
ARG   HD2  H  N N 85  
ARG   HD3  H  N N 86  
ARG   HE   H  N N 87  
ARG   HH11 H  N N 88  
ARG   HH12 H  N N 89  
ARG   HH21 H  N N 90  
ARG   HH22 H  N N 91  
ARG   HXT  H  N N 92  
ASN   N    N  N N 93  
ASN   CA   C  N S 94  
ASN   C    C  N N 95  
ASN   O    O  N N 96  
ASN   CB   C  N N 97  
ASN   CG   C  N N 98  
ASN   OD1  O  N N 99  
ASN   ND2  N  N N 100 
ASN   OXT  O  N N 101 
ASN   H    H  N N 102 
ASN   H2   H  N N 103 
ASN   HA   H  N N 104 
ASN   HB2  H  N N 105 
ASN   HB3  H  N N 106 
ASN   HD21 H  N N 107 
ASN   HD22 H  N N 108 
ASN   HXT  H  N N 109 
ASP   N    N  N N 110 
ASP   CA   C  N S 111 
ASP   C    C  N N 112 
ASP   O    O  N N 113 
ASP   CB   C  N N 114 
ASP   CG   C  N N 115 
ASP   OD1  O  N N 116 
ASP   OD2  O  N N 117 
ASP   OXT  O  N N 118 
ASP   H    H  N N 119 
ASP   H2   H  N N 120 
ASP   HA   H  N N 121 
ASP   HB2  H  N N 122 
ASP   HB3  H  N N 123 
ASP   HD2  H  N N 124 
ASP   HXT  H  N N 125 
CYS   N    N  N N 126 
CYS   CA   C  N R 127 
CYS   C    C  N N 128 
CYS   O    O  N N 129 
CYS   CB   C  N N 130 
CYS   SG   S  N N 131 
CYS   OXT  O  N N 132 
CYS   H    H  N N 133 
CYS   H2   H  N N 134 
CYS   HA   H  N N 135 
CYS   HB2  H  N N 136 
CYS   HB3  H  N N 137 
CYS   HG   H  N N 138 
CYS   HXT  H  N N 139 
GLN   N    N  N N 140 
GLN   CA   C  N S 141 
GLN   C    C  N N 142 
GLN   O    O  N N 143 
GLN   CB   C  N N 144 
GLN   CG   C  N N 145 
GLN   CD   C  N N 146 
GLN   OE1  O  N N 147 
GLN   NE2  N  N N 148 
GLN   OXT  O  N N 149 
GLN   H    H  N N 150 
GLN   H2   H  N N 151 
GLN   HA   H  N N 152 
GLN   HB2  H  N N 153 
GLN   HB3  H  N N 154 
GLN   HG2  H  N N 155 
GLN   HG3  H  N N 156 
GLN   HE21 H  N N 157 
GLN   HE22 H  N N 158 
GLN   HXT  H  N N 159 
GLU   N    N  N N 160 
GLU   CA   C  N S 161 
GLU   C    C  N N 162 
GLU   O    O  N N 163 
GLU   CB   C  N N 164 
GLU   CG   C  N N 165 
GLU   CD   C  N N 166 
GLU   OE1  O  N N 167 
GLU   OE2  O  N N 168 
GLU   OXT  O  N N 169 
GLU   H    H  N N 170 
GLU   H2   H  N N 171 
GLU   HA   H  N N 172 
GLU   HB2  H  N N 173 
GLU   HB3  H  N N 174 
GLU   HG2  H  N N 175 
GLU   HG3  H  N N 176 
GLU   HE2  H  N N 177 
GLU   HXT  H  N N 178 
GLY   N    N  N N 179 
GLY   CA   C  N N 180 
GLY   C    C  N N 181 
GLY   O    O  N N 182 
GLY   OXT  O  N N 183 
GLY   H    H  N N 184 
GLY   H2   H  N N 185 
GLY   HA2  H  N N 186 
GLY   HA3  H  N N 187 
GLY   HXT  H  N N 188 
HIS   N    N  N N 189 
HIS   CA   C  N S 190 
HIS   C    C  N N 191 
HIS   O    O  N N 192 
HIS   CB   C  N N 193 
HIS   CG   C  Y N 194 
HIS   ND1  N  Y N 195 
HIS   CD2  C  Y N 196 
HIS   CE1  C  Y N 197 
HIS   NE2  N  Y N 198 
HIS   OXT  O  N N 199 
HIS   H    H  N N 200 
HIS   H2   H  N N 201 
HIS   HA   H  N N 202 
HIS   HB2  H  N N 203 
HIS   HB3  H  N N 204 
HIS   HD1  H  N N 205 
HIS   HD2  H  N N 206 
HIS   HE1  H  N N 207 
HIS   HE2  H  N N 208 
HIS   HXT  H  N N 209 
HOH   O    O  N N 210 
HOH   H1   H  N N 211 
HOH   H2   H  N N 212 
ILE   N    N  N N 213 
ILE   CA   C  N S 214 
ILE   C    C  N N 215 
ILE   O    O  N N 216 
ILE   CB   C  N S 217 
ILE   CG1  C  N N 218 
ILE   CG2  C  N N 219 
ILE   CD1  C  N N 220 
ILE   OXT  O  N N 221 
ILE   H    H  N N 222 
ILE   H2   H  N N 223 
ILE   HA   H  N N 224 
ILE   HB   H  N N 225 
ILE   HG12 H  N N 226 
ILE   HG13 H  N N 227 
ILE   HG21 H  N N 228 
ILE   HG22 H  N N 229 
ILE   HG23 H  N N 230 
ILE   HD11 H  N N 231 
ILE   HD12 H  N N 232 
ILE   HD13 H  N N 233 
ILE   HXT  H  N N 234 
LEU   N    N  N N 235 
LEU   CA   C  N S 236 
LEU   C    C  N N 237 
LEU   O    O  N N 238 
LEU   CB   C  N N 239 
LEU   CG   C  N N 240 
LEU   CD1  C  N N 241 
LEU   CD2  C  N N 242 
LEU   OXT  O  N N 243 
LEU   H    H  N N 244 
LEU   H2   H  N N 245 
LEU   HA   H  N N 246 
LEU   HB2  H  N N 247 
LEU   HB3  H  N N 248 
LEU   HG   H  N N 249 
LEU   HD11 H  N N 250 
LEU   HD12 H  N N 251 
LEU   HD13 H  N N 252 
LEU   HD21 H  N N 253 
LEU   HD22 H  N N 254 
LEU   HD23 H  N N 255 
LEU   HXT  H  N N 256 
LYS   N    N  N N 257 
LYS   CA   C  N S 258 
LYS   C    C  N N 259 
LYS   O    O  N N 260 
LYS   CB   C  N N 261 
LYS   CG   C  N N 262 
LYS   CD   C  N N 263 
LYS   CE   C  N N 264 
LYS   NZ   N  N N 265 
LYS   OXT  O  N N 266 
LYS   H    H  N N 267 
LYS   H2   H  N N 268 
LYS   HA   H  N N 269 
LYS   HB2  H  N N 270 
LYS   HB3  H  N N 271 
LYS   HG2  H  N N 272 
LYS   HG3  H  N N 273 
LYS   HD2  H  N N 274 
LYS   HD3  H  N N 275 
LYS   HE2  H  N N 276 
LYS   HE3  H  N N 277 
LYS   HZ1  H  N N 278 
LYS   HZ2  H  N N 279 
LYS   HZ3  H  N N 280 
LYS   HXT  H  N N 281 
MET   N    N  N N 282 
MET   CA   C  N S 283 
MET   C    C  N N 284 
MET   O    O  N N 285 
MET   CB   C  N N 286 
MET   CG   C  N N 287 
MET   SD   S  N N 288 
MET   CE   C  N N 289 
MET   OXT  O  N N 290 
MET   H    H  N N 291 
MET   H2   H  N N 292 
MET   HA   H  N N 293 
MET   HB2  H  N N 294 
MET   HB3  H  N N 295 
MET   HG2  H  N N 296 
MET   HG3  H  N N 297 
MET   HE1  H  N N 298 
MET   HE2  H  N N 299 
MET   HE3  H  N N 300 
MET   HXT  H  N N 301 
MG    MG   MG N N 302 
PHE   N    N  N N 303 
PHE   CA   C  N S 304 
PHE   C    C  N N 305 
PHE   O    O  N N 306 
PHE   CB   C  N N 307 
PHE   CG   C  Y N 308 
PHE   CD1  C  Y N 309 
PHE   CD2  C  Y N 310 
PHE   CE1  C  Y N 311 
PHE   CE2  C  Y N 312 
PHE   CZ   C  Y N 313 
PHE   OXT  O  N N 314 
PHE   H    H  N N 315 
PHE   H2   H  N N 316 
PHE   HA   H  N N 317 
PHE   HB2  H  N N 318 
PHE   HB3  H  N N 319 
PHE   HD1  H  N N 320 
PHE   HD2  H  N N 321 
PHE   HE1  H  N N 322 
PHE   HE2  H  N N 323 
PHE   HZ   H  N N 324 
PHE   HXT  H  N N 325 
PRO   N    N  N N 326 
PRO   CA   C  N S 327 
PRO   C    C  N N 328 
PRO   O    O  N N 329 
PRO   CB   C  N N 330 
PRO   CG   C  N N 331 
PRO   CD   C  N N 332 
PRO   OXT  O  N N 333 
PRO   H    H  N N 334 
PRO   HA   H  N N 335 
PRO   HB2  H  N N 336 
PRO   HB3  H  N N 337 
PRO   HG2  H  N N 338 
PRO   HG3  H  N N 339 
PRO   HD2  H  N N 340 
PRO   HD3  H  N N 341 
PRO   HXT  H  N N 342 
SER   N    N  N N 343 
SER   CA   C  N S 344 
SER   C    C  N N 345 
SER   O    O  N N 346 
SER   CB   C  N N 347 
SER   OG   O  N N 348 
SER   OXT  O  N N 349 
SER   H    H  N N 350 
SER   H2   H  N N 351 
SER   HA   H  N N 352 
SER   HB2  H  N N 353 
SER   HB3  H  N N 354 
SER   HG   H  N N 355 
SER   HXT  H  N N 356 
THR   N    N  N N 357 
THR   CA   C  N S 358 
THR   C    C  N N 359 
THR   O    O  N N 360 
THR   CB   C  N R 361 
THR   OG1  O  N N 362 
THR   CG2  C  N N 363 
THR   OXT  O  N N 364 
THR   H    H  N N 365 
THR   H2   H  N N 366 
THR   HA   H  N N 367 
THR   HB   H  N N 368 
THR   HG1  H  N N 369 
THR   HG21 H  N N 370 
THR   HG22 H  N N 371 
THR   HG23 H  N N 372 
THR   HXT  H  N N 373 
TRP   N    N  N N 374 
TRP   CA   C  N S 375 
TRP   C    C  N N 376 
TRP   O    O  N N 377 
TRP   CB   C  N N 378 
TRP   CG   C  Y N 379 
TRP   CD1  C  Y N 380 
TRP   CD2  C  Y N 381 
TRP   NE1  N  Y N 382 
TRP   CE2  C  Y N 383 
TRP   CE3  C  Y N 384 
TRP   CZ2  C  Y N 385 
TRP   CZ3  C  Y N 386 
TRP   CH2  C  Y N 387 
TRP   OXT  O  N N 388 
TRP   H    H  N N 389 
TRP   H2   H  N N 390 
TRP   HA   H  N N 391 
TRP   HB2  H  N N 392 
TRP   HB3  H  N N 393 
TRP   HD1  H  N N 394 
TRP   HE1  H  N N 395 
TRP   HE3  H  N N 396 
TRP   HZ2  H  N N 397 
TRP   HZ3  H  N N 398 
TRP   HH2  H  N N 399 
TRP   HXT  H  N N 400 
TYR   N    N  N N 401 
TYR   CA   C  N S 402 
TYR   C    C  N N 403 
TYR   O    O  N N 404 
TYR   CB   C  N N 405 
TYR   CG   C  Y N 406 
TYR   CD1  C  Y N 407 
TYR   CD2  C  Y N 408 
TYR   CE1  C  Y N 409 
TYR   CE2  C  Y N 410 
TYR   CZ   C  Y N 411 
TYR   OH   O  N N 412 
TYR   OXT  O  N N 413 
TYR   H    H  N N 414 
TYR   H2   H  N N 415 
TYR   HA   H  N N 416 
TYR   HB2  H  N N 417 
TYR   HB3  H  N N 418 
TYR   HD1  H  N N 419 
TYR   HD2  H  N N 420 
TYR   HE1  H  N N 421 
TYR   HE2  H  N N 422 
TYR   HH   H  N N 423 
TYR   HXT  H  N N 424 
VAL   N    N  N N 425 
VAL   CA   C  N S 426 
VAL   C    C  N N 427 
VAL   O    O  N N 428 
VAL   CB   C  N N 429 
VAL   CG1  C  N N 430 
VAL   CG2  C  N N 431 
VAL   OXT  O  N N 432 
VAL   H    H  N N 433 
VAL   H2   H  N N 434 
VAL   HA   H  N N 435 
VAL   HB   H  N N 436 
VAL   HG11 H  N N 437 
VAL   HG12 H  N N 438 
VAL   HG13 H  N N 439 
VAL   HG21 H  N N 440 
VAL   HG22 H  N N 441 
VAL   HG23 H  N N 442 
VAL   HXT  H  N N 443 
ZN    ZN   ZN N N 444 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1ELJ C   C1   sing N N 1   
A1ELJ N   C1   sing N N 2   
A1ELJ N   C2   sing N N 3   
A1ELJ C2  C3   sing N N 4   
A1ELJ C3  C4   sing N N 5   
A1ELJ C4  N1   doub Y N 6   
A1ELJ N1  C5   sing Y N 7   
A1ELJ C5  C6   doub Y N 8   
A1ELJ C6  C7   sing Y N 9   
A1ELJ C7  C8   doub Y N 10  
A1ELJ C9  C8   sing N N 11  
A1ELJ N2  C9   trip N N 12  
A1ELJ C8  C10  sing Y N 13  
A1ELJ C10 C11  doub Y N 14  
A1ELJ C5  C11  sing Y N 15  
A1ELJ C11 C12  sing Y N 16  
A1ELJ C12 C13  doub Y N 17  
A1ELJ C4  C13  sing Y N 18  
A1ELJ C13 C14  sing N N 19  
A1ELJ C14 N    sing N N 20  
A1ELJ C15 C14  sing N N 21  
A1ELJ C16 C15  sing N N 22  
A1ELJ C17 C16  sing N N 23  
A1ELJ C17 C18  doub Y N 24  
A1ELJ C18 C19  sing Y N 25  
A1ELJ C19 C20  doub Y N 26  
A1ELJ O   C20  sing N N 27  
A1ELJ C21 O    sing N N 28  
A1ELJ C20 C22  sing Y N 29  
A1ELJ CL  C22  sing N N 30  
A1ELJ C22 C23  doub Y N 31  
A1ELJ C23 C17  sing Y N 32  
A1ELJ N3  C16  sing N N 33  
A1ELJ C12 N3   sing N N 34  
A1ELJ C1  O1   doub N N 35  
A1ELJ C15 H11  sing N N 36  
A1ELJ C15 H12  sing N N 37  
A1ELJ C18 H14  sing N N 38  
A1ELJ C19 H15  sing N N 39  
A1ELJ C23 H19  sing N N 40  
A1ELJ C10 H9   sing N N 41  
A1ELJ C14 H10  sing N N 42  
A1ELJ C16 H13  sing N N 43  
A1ELJ C2  H4   sing N N 44  
A1ELJ C2  H3   sing N N 45  
A1ELJ C21 H18  sing N N 46  
A1ELJ C21 H17  sing N N 47  
A1ELJ C21 H16  sing N N 48  
A1ELJ C3  H6   sing N N 49  
A1ELJ C3  H5   sing N N 50  
A1ELJ C6  H7   sing N N 51  
A1ELJ C7  H8   sing N N 52  
A1ELJ N3  H20  sing N N 53  
A1ELJ C   H    sing N N 54  
A1ELJ C   H1   sing N N 55  
A1ELJ C   H2   sing N N 56  
ALA   N   CA   sing N N 57  
ALA   N   H    sing N N 58  
ALA   N   H2   sing N N 59  
ALA   CA  C    sing N N 60  
ALA   CA  CB   sing N N 61  
ALA   CA  HA   sing N N 62  
ALA   C   O    doub N N 63  
ALA   C   OXT  sing N N 64  
ALA   CB  HB1  sing N N 65  
ALA   CB  HB2  sing N N 66  
ALA   CB  HB3  sing N N 67  
ALA   OXT HXT  sing N N 68  
ARG   N   CA   sing N N 69  
ARG   N   H    sing N N 70  
ARG   N   H2   sing N N 71  
ARG   CA  C    sing N N 72  
ARG   CA  CB   sing N N 73  
ARG   CA  HA   sing N N 74  
ARG   C   O    doub N N 75  
ARG   C   OXT  sing N N 76  
ARG   CB  CG   sing N N 77  
ARG   CB  HB2  sing N N 78  
ARG   CB  HB3  sing N N 79  
ARG   CG  CD   sing N N 80  
ARG   CG  HG2  sing N N 81  
ARG   CG  HG3  sing N N 82  
ARG   CD  NE   sing N N 83  
ARG   CD  HD2  sing N N 84  
ARG   CD  HD3  sing N N 85  
ARG   NE  CZ   sing N N 86  
ARG   NE  HE   sing N N 87  
ARG   CZ  NH1  sing N N 88  
ARG   CZ  NH2  doub N N 89  
ARG   NH1 HH11 sing N N 90  
ARG   NH1 HH12 sing N N 91  
ARG   NH2 HH21 sing N N 92  
ARG   NH2 HH22 sing N N 93  
ARG   OXT HXT  sing N N 94  
ASN   N   CA   sing N N 95  
ASN   N   H    sing N N 96  
ASN   N   H2   sing N N 97  
ASN   CA  C    sing N N 98  
ASN   CA  CB   sing N N 99  
ASN   CA  HA   sing N N 100 
ASN   C   O    doub N N 101 
ASN   C   OXT  sing N N 102 
ASN   CB  CG   sing N N 103 
ASN   CB  HB2  sing N N 104 
ASN   CB  HB3  sing N N 105 
ASN   CG  OD1  doub N N 106 
ASN   CG  ND2  sing N N 107 
ASN   ND2 HD21 sing N N 108 
ASN   ND2 HD22 sing N N 109 
ASN   OXT HXT  sing N N 110 
ASP   N   CA   sing N N 111 
ASP   N   H    sing N N 112 
ASP   N   H2   sing N N 113 
ASP   CA  C    sing N N 114 
ASP   CA  CB   sing N N 115 
ASP   CA  HA   sing N N 116 
ASP   C   O    doub N N 117 
ASP   C   OXT  sing N N 118 
ASP   CB  CG   sing N N 119 
ASP   CB  HB2  sing N N 120 
ASP   CB  HB3  sing N N 121 
ASP   CG  OD1  doub N N 122 
ASP   CG  OD2  sing N N 123 
ASP   OD2 HD2  sing N N 124 
ASP   OXT HXT  sing N N 125 
CYS   N   CA   sing N N 126 
CYS   N   H    sing N N 127 
CYS   N   H2   sing N N 128 
CYS   CA  C    sing N N 129 
CYS   CA  CB   sing N N 130 
CYS   CA  HA   sing N N 131 
CYS   C   O    doub N N 132 
CYS   C   OXT  sing N N 133 
CYS   CB  SG   sing N N 134 
CYS   CB  HB2  sing N N 135 
CYS   CB  HB3  sing N N 136 
CYS   SG  HG   sing N N 137 
CYS   OXT HXT  sing N N 138 
GLN   N   CA   sing N N 139 
GLN   N   H    sing N N 140 
GLN   N   H2   sing N N 141 
GLN   CA  C    sing N N 142 
GLN   CA  CB   sing N N 143 
GLN   CA  HA   sing N N 144 
GLN   C   O    doub N N 145 
GLN   C   OXT  sing N N 146 
GLN   CB  CG   sing N N 147 
GLN   CB  HB2  sing N N 148 
GLN   CB  HB3  sing N N 149 
GLN   CG  CD   sing N N 150 
GLN   CG  HG2  sing N N 151 
GLN   CG  HG3  sing N N 152 
GLN   CD  OE1  doub N N 153 
GLN   CD  NE2  sing N N 154 
GLN   NE2 HE21 sing N N 155 
GLN   NE2 HE22 sing N N 156 
GLN   OXT HXT  sing N N 157 
GLU   N   CA   sing N N 158 
GLU   N   H    sing N N 159 
GLU   N   H2   sing N N 160 
GLU   CA  C    sing N N 161 
GLU   CA  CB   sing N N 162 
GLU   CA  HA   sing N N 163 
GLU   C   O    doub N N 164 
GLU   C   OXT  sing N N 165 
GLU   CB  CG   sing N N 166 
GLU   CB  HB2  sing N N 167 
GLU   CB  HB3  sing N N 168 
GLU   CG  CD   sing N N 169 
GLU   CG  HG2  sing N N 170 
GLU   CG  HG3  sing N N 171 
GLU   CD  OE1  doub N N 172 
GLU   CD  OE2  sing N N 173 
GLU   OE2 HE2  sing N N 174 
GLU   OXT HXT  sing N N 175 
GLY   N   CA   sing N N 176 
GLY   N   H    sing N N 177 
GLY   N   H2   sing N N 178 
GLY   CA  C    sing N N 179 
GLY   CA  HA2  sing N N 180 
GLY   CA  HA3  sing N N 181 
GLY   C   O    doub N N 182 
GLY   C   OXT  sing N N 183 
GLY   OXT HXT  sing N N 184 
HIS   N   CA   sing N N 185 
HIS   N   H    sing N N 186 
HIS   N   H2   sing N N 187 
HIS   CA  C    sing N N 188 
HIS   CA  CB   sing N N 189 
HIS   CA  HA   sing N N 190 
HIS   C   O    doub N N 191 
HIS   C   OXT  sing N N 192 
HIS   CB  CG   sing N N 193 
HIS   CB  HB2  sing N N 194 
HIS   CB  HB3  sing N N 195 
HIS   CG  ND1  sing Y N 196 
HIS   CG  CD2  doub Y N 197 
HIS   ND1 CE1  doub Y N 198 
HIS   ND1 HD1  sing N N 199 
HIS   CD2 NE2  sing Y N 200 
HIS   CD2 HD2  sing N N 201 
HIS   CE1 NE2  sing Y N 202 
HIS   CE1 HE1  sing N N 203 
HIS   NE2 HE2  sing N N 204 
HIS   OXT HXT  sing N N 205 
HOH   O   H1   sing N N 206 
HOH   O   H2   sing N N 207 
ILE   N   CA   sing N N 208 
ILE   N   H    sing N N 209 
ILE   N   H2   sing N N 210 
ILE   CA  C    sing N N 211 
ILE   CA  CB   sing N N 212 
ILE   CA  HA   sing N N 213 
ILE   C   O    doub N N 214 
ILE   C   OXT  sing N N 215 
ILE   CB  CG1  sing N N 216 
ILE   CB  CG2  sing N N 217 
ILE   CB  HB   sing N N 218 
ILE   CG1 CD1  sing N N 219 
ILE   CG1 HG12 sing N N 220 
ILE   CG1 HG13 sing N N 221 
ILE   CG2 HG21 sing N N 222 
ILE   CG2 HG22 sing N N 223 
ILE   CG2 HG23 sing N N 224 
ILE   CD1 HD11 sing N N 225 
ILE   CD1 HD12 sing N N 226 
ILE   CD1 HD13 sing N N 227 
ILE   OXT HXT  sing N N 228 
LEU   N   CA   sing N N 229 
LEU   N   H    sing N N 230 
LEU   N   H2   sing N N 231 
LEU   CA  C    sing N N 232 
LEU   CA  CB   sing N N 233 
LEU   CA  HA   sing N N 234 
LEU   C   O    doub N N 235 
LEU   C   OXT  sing N N 236 
LEU   CB  CG   sing N N 237 
LEU   CB  HB2  sing N N 238 
LEU   CB  HB3  sing N N 239 
LEU   CG  CD1  sing N N 240 
LEU   CG  CD2  sing N N 241 
LEU   CG  HG   sing N N 242 
LEU   CD1 HD11 sing N N 243 
LEU   CD1 HD12 sing N N 244 
LEU   CD1 HD13 sing N N 245 
LEU   CD2 HD21 sing N N 246 
LEU   CD2 HD22 sing N N 247 
LEU   CD2 HD23 sing N N 248 
LEU   OXT HXT  sing N N 249 
LYS   N   CA   sing N N 250 
LYS   N   H    sing N N 251 
LYS   N   H2   sing N N 252 
LYS   CA  C    sing N N 253 
LYS   CA  CB   sing N N 254 
LYS   CA  HA   sing N N 255 
LYS   C   O    doub N N 256 
LYS   C   OXT  sing N N 257 
LYS   CB  CG   sing N N 258 
LYS   CB  HB2  sing N N 259 
LYS   CB  HB3  sing N N 260 
LYS   CG  CD   sing N N 261 
LYS   CG  HG2  sing N N 262 
LYS   CG  HG3  sing N N 263 
LYS   CD  CE   sing N N 264 
LYS   CD  HD2  sing N N 265 
LYS   CD  HD3  sing N N 266 
LYS   CE  NZ   sing N N 267 
LYS   CE  HE2  sing N N 268 
LYS   CE  HE3  sing N N 269 
LYS   NZ  HZ1  sing N N 270 
LYS   NZ  HZ2  sing N N 271 
LYS   NZ  HZ3  sing N N 272 
LYS   OXT HXT  sing N N 273 
MET   N   CA   sing N N 274 
MET   N   H    sing N N 275 
MET   N   H2   sing N N 276 
MET   CA  C    sing N N 277 
MET   CA  CB   sing N N 278 
MET   CA  HA   sing N N 279 
MET   C   O    doub N N 280 
MET   C   OXT  sing N N 281 
MET   CB  CG   sing N N 282 
MET   CB  HB2  sing N N 283 
MET   CB  HB3  sing N N 284 
MET   CG  SD   sing N N 285 
MET   CG  HG2  sing N N 286 
MET   CG  HG3  sing N N 287 
MET   SD  CE   sing N N 288 
MET   CE  HE1  sing N N 289 
MET   CE  HE2  sing N N 290 
MET   CE  HE3  sing N N 291 
MET   OXT HXT  sing N N 292 
PHE   N   CA   sing N N 293 
PHE   N   H    sing N N 294 
PHE   N   H2   sing N N 295 
PHE   CA  C    sing N N 296 
PHE   CA  CB   sing N N 297 
PHE   CA  HA   sing N N 298 
PHE   C   O    doub N N 299 
PHE   C   OXT  sing N N 300 
PHE   CB  CG   sing N N 301 
PHE   CB  HB2  sing N N 302 
PHE   CB  HB3  sing N N 303 
PHE   CG  CD1  doub Y N 304 
PHE   CG  CD2  sing Y N 305 
PHE   CD1 CE1  sing Y N 306 
PHE   CD1 HD1  sing N N 307 
PHE   CD2 CE2  doub Y N 308 
PHE   CD2 HD2  sing N N 309 
PHE   CE1 CZ   doub Y N 310 
PHE   CE1 HE1  sing N N 311 
PHE   CE2 CZ   sing Y N 312 
PHE   CE2 HE2  sing N N 313 
PHE   CZ  HZ   sing N N 314 
PHE   OXT HXT  sing N N 315 
PRO   N   CA   sing N N 316 
PRO   N   CD   sing N N 317 
PRO   N   H    sing N N 318 
PRO   CA  C    sing N N 319 
PRO   CA  CB   sing N N 320 
PRO   CA  HA   sing N N 321 
PRO   C   O    doub N N 322 
PRO   C   OXT  sing N N 323 
PRO   CB  CG   sing N N 324 
PRO   CB  HB2  sing N N 325 
PRO   CB  HB3  sing N N 326 
PRO   CG  CD   sing N N 327 
PRO   CG  HG2  sing N N 328 
PRO   CG  HG3  sing N N 329 
PRO   CD  HD2  sing N N 330 
PRO   CD  HD3  sing N N 331 
PRO   OXT HXT  sing N N 332 
SER   N   CA   sing N N 333 
SER   N   H    sing N N 334 
SER   N   H2   sing N N 335 
SER   CA  C    sing N N 336 
SER   CA  CB   sing N N 337 
SER   CA  HA   sing N N 338 
SER   C   O    doub N N 339 
SER   C   OXT  sing N N 340 
SER   CB  OG   sing N N 341 
SER   CB  HB2  sing N N 342 
SER   CB  HB3  sing N N 343 
SER   OG  HG   sing N N 344 
SER   OXT HXT  sing N N 345 
THR   N   CA   sing N N 346 
THR   N   H    sing N N 347 
THR   N   H2   sing N N 348 
THR   CA  C    sing N N 349 
THR   CA  CB   sing N N 350 
THR   CA  HA   sing N N 351 
THR   C   O    doub N N 352 
THR   C   OXT  sing N N 353 
THR   CB  OG1  sing N N 354 
THR   CB  CG2  sing N N 355 
THR   CB  HB   sing N N 356 
THR   OG1 HG1  sing N N 357 
THR   CG2 HG21 sing N N 358 
THR   CG2 HG22 sing N N 359 
THR   CG2 HG23 sing N N 360 
THR   OXT HXT  sing N N 361 
TRP   N   CA   sing N N 362 
TRP   N   H    sing N N 363 
TRP   N   H2   sing N N 364 
TRP   CA  C    sing N N 365 
TRP   CA  CB   sing N N 366 
TRP   CA  HA   sing N N 367 
TRP   C   O    doub N N 368 
TRP   C   OXT  sing N N 369 
TRP   CB  CG   sing N N 370 
TRP   CB  HB2  sing N N 371 
TRP   CB  HB3  sing N N 372 
TRP   CG  CD1  doub Y N 373 
TRP   CG  CD2  sing Y N 374 
TRP   CD1 NE1  sing Y N 375 
TRP   CD1 HD1  sing N N 376 
TRP   CD2 CE2  doub Y N 377 
TRP   CD2 CE3  sing Y N 378 
TRP   NE1 CE2  sing Y N 379 
TRP   NE1 HE1  sing N N 380 
TRP   CE2 CZ2  sing Y N 381 
TRP   CE3 CZ3  doub Y N 382 
TRP   CE3 HE3  sing N N 383 
TRP   CZ2 CH2  doub Y N 384 
TRP   CZ2 HZ2  sing N N 385 
TRP   CZ3 CH2  sing Y N 386 
TRP   CZ3 HZ3  sing N N 387 
TRP   CH2 HH2  sing N N 388 
TRP   OXT HXT  sing N N 389 
TYR   N   CA   sing N N 390 
TYR   N   H    sing N N 391 
TYR   N   H2   sing N N 392 
TYR   CA  C    sing N N 393 
TYR   CA  CB   sing N N 394 
TYR   CA  HA   sing N N 395 
TYR   C   O    doub N N 396 
TYR   C   OXT  sing N N 397 
TYR   CB  CG   sing N N 398 
TYR   CB  HB2  sing N N 399 
TYR   CB  HB3  sing N N 400 
TYR   CG  CD1  doub Y N 401 
TYR   CG  CD2  sing Y N 402 
TYR   CD1 CE1  sing Y N 403 
TYR   CD1 HD1  sing N N 404 
TYR   CD2 CE2  doub Y N 405 
TYR   CD2 HD2  sing N N 406 
TYR   CE1 CZ   doub Y N 407 
TYR   CE1 HE1  sing N N 408 
TYR   CE2 CZ   sing Y N 409 
TYR   CE2 HE2  sing N N 410 
TYR   CZ  OH   sing N N 411 
TYR   OH  HH   sing N N 412 
TYR   OXT HXT  sing N N 413 
VAL   N   CA   sing N N 414 
VAL   N   H    sing N N 415 
VAL   N   H2   sing N N 416 
VAL   CA  C    sing N N 417 
VAL   CA  CB   sing N N 418 
VAL   CA  HA   sing N N 419 
VAL   C   O    doub N N 420 
VAL   C   OXT  sing N N 421 
VAL   CB  CG1  sing N N 422 
VAL   CB  CG2  sing N N 423 
VAL   CB  HB   sing N N 424 
VAL   CG1 HG11 sing N N 425 
VAL   CG1 HG12 sing N N 426 
VAL   CG1 HG13 sing N N 427 
VAL   CG2 HG21 sing N N 428 
VAL   CG2 HG22 sing N N 429 
VAL   CG2 HG23 sing N N 430 
VAL   OXT HXT  sing N N 431 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           82373732 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   2H42 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 31 2 1' 
_space_group.name_Hall        
;P 31 2"
;
_space_group.IT_number        152 
_space_group.crystal_system   trigonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9LSL 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.013437 
_atom_sites.fract_transf_matrix[1][2]   0.007758 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.015516 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.007573 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CL ? ? 9.50761  7.44341 ? ? 1.04373  23.83732 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
MG ? ? 9.41153  2.53737 ? ? 2.59044  63.03566 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
ZN ? ? 24.64596 5.25405 ? ? 2.14387  29.76375 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . THR   A 1 3   ? 33.98437 -46.19550 -9.25879  1.000 57.75481  ? 537  THR   A N   1 
ATOM   2    C  CA  . THR   A 1 3   ? 34.07783 -45.74897 -7.87521  1.000 62.91022  ? 537  THR   A CA  1 
ATOM   3    C  C   . THR   A 1 3   ? 35.53960 -45.70220 -7.43432  1.000 64.00544  ? 537  THR   A C   1 
ATOM   4    O  O   . THR   A 1 3   ? 35.90268 -44.95011 -6.53215  1.000 61.50489  ? 537  THR   A O   1 
ATOM   5    C  CB  . THR   A 1 3   ? 33.25482 -46.65895 -6.92825  1.000 65.29444  ? 537  THR   A CB  1 
ATOM   6    O  OG1 . THR   A 1 3   ? 32.71892 -45.87852 -5.85110  1.000 58.63005  ? 537  THR   A OG1 1 
ATOM   7    C  CG2 . THR   A 1 3   ? 34.10514 -47.79275 -6.36461  1.000 54.92880  ? 537  THR   A CG2 1 
ATOM   8    N  N   . ARG   A 1 4   ? 36.37548 -46.51779 -8.08743  1.000 59.74981  ? 538  ARG   A N   1 
ATOM   9    C  CA  . ARG   A 1 4   ? 37.81882 -46.42629 -7.89238  1.000 56.53727  ? 538  ARG   A CA  1 
ATOM   10   C  C   . ARG   A 1 4   ? 38.36258 -45.13735 -8.48856  1.000 61.91135  ? 538  ARG   A C   1 
ATOM   11   O  O   . ARG   A 1 4   ? 39.32942 -44.56750 -7.96842  1.000 63.90442  ? 538  ARG   A O   1 
ATOM   12   C  CB  . ARG   A 1 4   ? 38.52609 -47.63236 -8.51381  1.000 66.98892  ? 538  ARG   A CB  1 
ATOM   13   C  CG  . ARG   A 1 4   ? 38.21110 -49.00735 -7.89739  1.000 66.30271  ? 538  ARG   A CG  1 
ATOM   14   C  CD  . ARG   A 1 4   ? 36.81185 -49.50892 -8.23090  1.000 63.36959  ? 538  ARG   A CD  1 
ATOM   15   N  NE  . ARG   A 1 4   ? 36.72122 -50.05443 -9.58001  1.000 71.19503  ? 538  ARG   A NE  1 
ATOM   16   C  CZ  . ARG   A 1 4   ? 35.60559 -50.52894 -10.11734 1.000 74.22642  ? 538  ARG   A CZ  1 
ATOM   17   N  NH1 . ARG   A 1 4   ? 34.46409 -50.52965 -9.44893  1.000 70.30954  ? 538  ARG   A NH1 1 
ATOM   18   N  NH2 . ARG   A 1 4   ? 35.63443 -51.01011 -11.35751 1.000 75.58233  ? 538  ARG   A NH2 1 
ATOM   19   N  N   . GLU   A 1 5   ? 37.74782 -44.67046 -9.57743  1.000 62.46706  ? 539  GLU   A N   1 
ATOM   20   C  CA  . GLU   A 1 5   ? 38.12435 -43.41101 -10.20654 1.000 54.86617  ? 539  GLU   A CA  1 
ATOM   21   C  C   . GLU   A 1 5   ? 37.50370 -42.22083 -9.48729  1.000 54.82027  ? 539  GLU   A C   1 
ATOM   22   O  O   . GLU   A 1 5   ? 38.16108 -41.18984 -9.30468  1.000 55.25831  ? 539  GLU   A O   1 
ATOM   23   C  CB  . GLU   A 1 5   ? 37.69643 -43.42232 -11.67406 1.000 53.14902  ? 539  GLU   A CB  1 
ATOM   24   C  CG  . GLU   A 1 5   ? 38.02997 -42.16379 -12.45216 1.000 52.48710  ? 539  GLU   A CG  1 
ATOM   25   C  CD  . GLU   A 1 5   ? 37.96509 -42.37800 -13.95366 1.000 52.55688  ? 539  GLU   A CD  1 
ATOM   26   O  OE1 . GLU   A 1 5   ? 37.51119 -43.45944 -14.38661 1.000 60.86495  ? 539  GLU   A OE1 1 
ATOM   27   O  OE2 . GLU   A 1 5   ? 38.35391 -41.45780 -14.70253 1.000 46.04967  ? 539  GLU   A OE2 1 
ATOM   28   N  N   . LEU   A 1 6   ? 36.23921 -42.34575 -9.07611  1.000 52.53928  ? 540  LEU   A N   1 
ATOM   29   C  CA  . LEU   A 1 6   ? 35.55639 -41.23131 -8.42825  1.000 51.13401  ? 540  LEU   A CA  1 
ATOM   30   C  C   . LEU   A 1 6   ? 36.15213 -40.92373 -7.06157  1.000 51.03848  ? 540  LEU   A C   1 
ATOM   31   O  O   . LEU   A 1 6   ? 36.20269 -39.75592 -6.65927  1.000 48.90237  ? 540  LEU   A O   1 
ATOM   32   C  CB  . LEU   A 1 6   ? 34.06141 -41.53125 -8.30824  1.000 53.45143  ? 540  LEU   A CB  1 
ATOM   33   C  CG  . LEU   A 1 6   ? 33.23725 -40.66367 -7.35446  1.000 50.55274  ? 540  LEU   A CG  1 
ATOM   34   C  CD1 . LEU   A 1 6   ? 32.68886 -39.45619 -8.08611  1.000 45.03464  ? 540  LEU   A CD1 1 
ATOM   35   C  CD2 . LEU   A 1 6   ? 32.10916 -41.46660 -6.72921  1.000 53.72252  ? 540  LEU   A CD2 1 
ATOM   36   N  N   . GLN   A 1 7   ? 36.61081 -41.94844 -6.33938  1.000 54.68436  ? 541  GLN   A N   1 
ATOM   37   C  CA  . GLN   A 1 7   ? 37.23936 -41.71635 -5.04264  1.000 55.04147  ? 541  GLN   A CA  1 
ATOM   38   C  C   . GLN   A 1 7   ? 38.51436 -40.89074 -5.18476  1.000 53.01297  ? 541  GLN   A C   1 
ATOM   39   O  O   . GLN   A 1 7   ? 38.78848 -40.01069 -4.36100  1.000 51.63998  ? 541  GLN   A O   1 
ATOM   40   C  CB  . GLN   A 1 7   ? 37.53585 -43.05296 -4.36338  1.000 56.79039  ? 541  GLN   A CB  1 
ATOM   41   C  CG  . GLN   A 1 7   ? 37.87054 -42.94531 -2.88544  1.000 64.34122  ? 541  GLN   A CG  1 
ATOM   42   C  CD  . GLN   A 1 7   ? 38.62952 -44.15293 -2.37837  1.000 67.09031  ? 541  GLN   A CD  1 
ATOM   43   O  OE1 . GLN   A 1 7   ? 39.56657 -44.62328 -3.02204  1.000 65.41631  ? 541  GLN   A OE1 1 
ATOM   44   N  NE2 . GLN   A 1 7   ? 38.22709 -44.66446 -1.22072  1.000 67.86852  ? 541  GLN   A NE2 1 
ATOM   45   N  N   . SER   A 1 8   ? 39.30513 -41.15764 -6.22831  1.000 50.46782  ? 542  SER   A N   1 
ATOM   46   C  CA  . SER   A 1 8   ? 40.54025 -40.40832 -6.43710  1.000 48.21448  ? 542  SER   A CA  1 
ATOM   47   C  C   . SER   A 1 8   ? 40.26394 -38.99118 -6.92415  1.000 50.78371  ? 542  SER   A C   1 
ATOM   48   O  O   . SER   A 1 8   ? 40.99428 -38.05855 -6.56519  1.000 50.44187  ? 542  SER   A O   1 
ATOM   49   C  CB  . SER   A 1 8   ? 41.44210 -41.14539 -7.42588  1.000 49.73364  ? 542  SER   A CB  1 
ATOM   50   O  OG  . SER   A 1 8   ? 40.70253 -42.07079 -8.20438  1.000 52.89892  ? 542  SER   A OG  1 
ATOM   51   N  N   . LEU   A 1 9   ? 39.21652 -38.80583 -7.72981  1.000 49.99844  ? 543  LEU   A N   1 
ATOM   52   C  CA  . LEU   A 1 9   ? 38.90601 -37.47193 -8.23105  1.000 48.40122  ? 543  LEU   A CA  1 
ATOM   53   C  C   . LEU   A 1 9   ? 38.30418 -36.59613 -7.13901  1.000 47.20578  ? 543  LEU   A C   1 
ATOM   54   O  O   . LEU   A 1 9   ? 38.63747 -35.40981 -7.03168  1.000 43.60610  ? 543  LEU   A O   1 
ATOM   55   C  CB  . LEU   A 1 9   ? 37.95730 -37.57144 -9.42220  1.000 52.60645  ? 543  LEU   A CB  1 
ATOM   56   C  CG  . LEU   A 1 9   ? 37.37492 -36.25173 -9.93384  1.000 48.82654  ? 543  LEU   A CG  1 
ATOM   57   C  CD1 . LEU   A 1 9   ? 38.47428 -35.29506 -10.38351 1.000 43.00103  ? 543  LEU   A CD1 1 
ATOM   58   C  CD2 . LEU   A 1 9   ? 36.38488 -36.52873 -11.05538 1.000 42.89738  ? 543  LEU   A CD2 1 
ATOM   59   N  N   . ALA   A 1 10  ? 37.42054 -37.16581 -6.31612  1.000 51.43194  ? 544  ALA   A N   1 
ATOM   60   C  CA  . ALA   A 1 10  ? 36.76416 -36.38610 -5.27167  1.000 53.78419  ? 544  ALA   A CA  1 
ATOM   61   C  C   . ALA   A 1 10  ? 37.75818 -35.91540 -4.21705  1.000 49.99295  ? 544  ALA   A C   1 
ATOM   62   O  O   . ALA   A 1 10  ? 37.61620 -34.81514 -3.67080  1.000 52.19183  ? 544  ALA   A O   1 
ATOM   63   C  CB  . ALA   A 1 10  ? 35.64744 -37.20802 -4.62874  1.000 47.25831  ? 544  ALA   A CB  1 
ATOM   64   N  N   . ALA   A 1 11  ? 38.76931 -36.73093 -3.91773  1.000 46.55369  ? 545  ALA   A N   1 
ATOM   65   C  CA  . ALA   A 1 11  ? 39.74043 -36.39796 -2.88349  1.000 49.45851  ? 545  ALA   A CA  1 
ATOM   66   C  C   . ALA   A 1 11  ? 40.84662 -35.47615 -3.37412  1.000 50.83804  ? 545  ALA   A C   1 
ATOM   67   O  O   . ALA   A 1 11  ? 41.61123 -34.96216 -2.55051  1.000 57.46853  ? 545  ALA   A O   1 
ATOM   68   C  CB  . ALA   A 1 11  ? 40.36256 -37.67507 -2.31484  1.000 46.04479  ? 545  ALA   A CB  1 
ATOM   69   N  N   . ALA   A 1 12  ? 40.95228 -35.25666 -4.68078  1.000 53.85904  ? 546  ALA   A N   1 
ATOM   70   C  CA  . ALA   A 1 12  ? 42.02217 -34.43603 -5.22180  1.000 50.68709  ? 546  ALA   A CA  1 
ATOM   71   C  C   . ALA   A 1 12  ? 41.80587 -32.96543 -4.86819  1.000 49.12773  ? 546  ALA   A C   1 
ATOM   72   O  O   . ALA   A 1 12  ? 40.72824 -32.54740 -4.43323  1.000 54.41384  ? 546  ALA   A O   1 
ATOM   73   C  CB  . ALA   A 1 12  ? 42.10936 -34.60686 -6.73797  1.000 46.13555  ? 546  ALA   A CB  1 
ATOM   74   N  N   . VAL   A 1 13  ? 42.85843 -32.17692 -5.05226  1.000 51.82833  ? 547  VAL   A N   1 
ATOM   75   C  CA  . VAL   A 1 13  ? 42.77032 -30.72378 -4.98549  1.000 50.14603  ? 547  VAL   A CA  1 
ATOM   76   C  C   . VAL   A 1 13  ? 42.62744 -30.20582 -6.40792  1.000 51.93261  ? 547  VAL   A C   1 
ATOM   77   O  O   . VAL   A 1 13  ? 43.26570 -30.71933 -7.33677  1.000 49.11909  ? 547  VAL   A O   1 
ATOM   78   C  CB  . VAL   A 1 13  ? 43.98872 -30.10710 -4.26414  1.000 51.91253  ? 547  VAL   A CB  1 
ATOM   79   C  CG1 . VAL   A 1 13  ? 45.22567 -30.08350 -5.16163  1.000 44.38215  ? 547  VAL   A CG1 1 
ATOM   80   C  CG2 . VAL   A 1 13  ? 43.66048 -28.70539 -3.76690  1.000 46.02036  ? 547  VAL   A CG2 1 
ATOM   81   N  N   . VAL   A 1 14  ? 41.74807 -29.22856 -6.59228  1.000 49.88002  ? 548  VAL   A N   1 
ATOM   82   C  CA  . VAL   A 1 14  ? 41.44179 -28.69158 -7.91647  1.000 43.70873  ? 548  VAL   A CA  1 
ATOM   83   C  C   . VAL   A 1 14  ? 42.35633 -27.48995 -8.14786  1.000 41.75899  ? 548  VAL   A C   1 
ATOM   84   O  O   . VAL   A 1 14  ? 42.14481 -26.43936 -7.51862  1.000 41.49601  ? 548  VAL   A O   1 
ATOM   85   C  CB  . VAL   A 1 14  ? 39.96350 -28.30675 -8.03509  1.000 41.61372  ? 548  VAL   A CB  1 
ATOM   86   C  CG1 . VAL   A 1 14  ? 39.70410 -27.56876 -9.34452  1.000 36.78023  ? 548  VAL   A CG1 1 
ATOM   87   C  CG2 . VAL   A 1 14  ? 39.08692 -29.54630 -7.92659  1.000 40.29973  ? 548  VAL   A CG2 1 
ATOM   88   N  N   . PRO   A 1 15  ? 43.37283 -27.60180 -9.00128  1.000 40.15456  ? 549  PRO   A N   1 
ATOM   89   C  CA  . PRO   A 1 15  ? 44.29490 -26.47922 -9.19914  1.000 36.65698  ? 549  PRO   A CA  1 
ATOM   90   C  C   . PRO   A 1 15  ? 43.58124 -25.26808 -9.78083  1.000 37.75882  ? 549  PRO   A C   1 
ATOM   91   O  O   . PRO   A 1 15  ? 42.50646 -25.36862 -10.37719 1.000 39.61628  ? 549  PRO   A O   1 
ATOM   92   C  CB  . PRO   A 1 15  ? 45.33650 -27.03630 -10.17721 1.000 35.70381  ? 549  PRO   A CB  1 
ATOM   93   C  CG  . PRO   A 1 15  ? 45.19013 -28.52527 -10.10444 1.000 32.84365  ? 549  PRO   A CG  1 
ATOM   94   C  CD  . PRO   A 1 15  ? 43.74679 -28.77603 -9.80394  1.000 38.17576  ? 549  PRO   A CD  1 
ATOM   95   N  N   . SER   A 1 16  ? 44.20593 -24.10607 -9.60112  1.000 41.46430  ? 550  SER   A N   1 
ATOM   96   C  CA  . SER   A 1 16  ? 43.61186 -22.85037 -10.02768 1.000 36.35812  ? 550  SER   A CA  1 
ATOM   97   C  C   . SER   A 1 16  ? 43.47385 -22.80580 -11.55037 1.000 39.29391  ? 550  SER   A C   1 
ATOM   98   O  O   . SER   A 1 16  ? 44.03999 -23.61940 -12.28446 1.000 38.85406  ? 550  SER   A O   1 
ATOM   99   C  CB  . SER   A 1 16  ? 44.45148 -21.67294 -9.53618  1.000 36.51828  ? 550  SER   A CB  1 
ATOM   100  O  OG  . SER   A 1 16  ? 45.55033 -21.43698 -10.39952 1.000 43.08277  ? 550  SER   A OG  1 
ATOM   101  N  N   . ALA   A 1 17  ? 42.69546 -21.82896 -12.02196 1.000 46.45426  ? 551  ALA   A N   1 
ATOM   102  C  CA  . ALA   A 1 17  ? 42.49060 -21.67805 -13.45863 1.000 44.74243  ? 551  ALA   A CA  1 
ATOM   103  C  C   . ALA   A 1 17  ? 43.77747 -21.28493 -14.17093 1.000 46.67000  ? 551  ALA   A C   1 
ATOM   104  O  O   . ALA   A 1 17  ? 43.99573 -21.67978 -15.32298 1.000 48.81369  ? 551  ALA   A O   1 
ATOM   105  C  CB  . ALA   A 1 17  ? 41.39626 -20.64544 -13.72737 1.000 39.81531  ? 551  ALA   A CB  1 
ATOM   106  N  N   . GLN   A 1 18  ? 44.64052 -20.51329 -13.50579 1.000 48.88378  ? 552  GLN   A N   1 
ATOM   107  C  CA  . GLN   A 1 18  ? 45.89093 -20.09926 -14.13346 1.000 48.67140  ? 552  GLN   A CA  1 
ATOM   108  C  C   . GLN   A 1 18  ? 46.85385 -21.27145 -14.27141 1.000 44.09691  ? 552  GLN   A C   1 
ATOM   109  O  O   . GLN   A 1 18  ? 47.52954 -21.40939 -15.29846 1.000 44.04203  ? 552  GLN   A O   1 
ATOM   110  C  CB  . GLN   A 1 18  ? 46.53331 -18.96694 -13.33403 1.000 54.31032  ? 552  GLN   A CB  1 
ATOM   111  C  CG  . GLN   A 1 18  ? 47.66565 -18.26885 -14.06849 1.000 61.26758  ? 552  GLN   A CG  1 
ATOM   112  C  CD  . GLN   A 1 18  ? 48.60170 -17.53215 -13.13450 1.000 66.09340  ? 552  GLN   A CD  1 
ATOM   113  O  OE1 . GLN   A 1 18  ? 48.77188 -17.91635 -11.97881 1.000 69.32429  ? 552  GLN   A OE1 1 
ATOM   114  N  NE2 . GLN   A 1 18  ? 49.21298 -16.46416 -13.63083 1.000 60.96653  ? 552  GLN   A NE2 1 
ATOM   115  N  N   . THR   A 1 19  ? 46.92994 -22.12458 -13.24725 1.000 47.08930  ? 553  THR   A N   1 
ATOM   116  C  CA  . THR   A 1 19  ? 47.77407 -23.31289 -13.32824 1.000 41.94597  ? 553  THR   A CA  1 
ATOM   117  C  C   . THR   A 1 19  ? 47.31200 -24.23137 -14.45070 1.000 46.72414  ? 553  THR   A C   1 
ATOM   118  O  O   . THR   A 1 19  ? 48.12454 -24.74073 -15.23254 1.000 47.81316  ? 553  THR   A O   1 
ATOM   119  C  CB  . THR   A 1 19  ? 47.76374 -24.05866 -11.99154 1.000 40.92331  ? 553  THR   A CB  1 
ATOM   120  O  OG1 . THR   A 1 19  ? 48.39174 -23.25562 -10.98549 1.000 36.85160  ? 553  THR   A OG1 1 
ATOM   121  C  CG2 . THR   A 1 19  ? 48.49788 -25.38705 -12.11170 1.000 35.91981  ? 553  THR   A CG2 1 
ATOM   122  N  N   . LEU   A 1 20  ? 46.00005 -24.43979 -14.55379 1.000 48.86012  ? 554  LEU   A N   1 
ATOM   123  C  CA  . LEU   A 1 20  ? 45.44697 -25.36149 -15.53517 1.000 43.37813  ? 554  LEU   A CA  1 
ATOM   124  C  C   . LEU   A 1 20  ? 45.45849 -24.80254 -16.95195 1.000 39.75862  ? 554  LEU   A C   1 
ATOM   125  O  O   . LEU   A 1 20  ? 45.16471 -25.55164 -17.88879 1.000 37.64571  ? 554  LEU   A O   1 
ATOM   126  C  CB  . LEU   A 1 20  ? 44.02118 -25.73380 -15.12622 1.000 43.50067  ? 554  LEU   A CB  1 
ATOM   127  C  CG  . LEU   A 1 20  ? 43.94576 -26.57735 -13.84939 1.000 41.84714  ? 554  LEU   A CG  1 
ATOM   128  C  CD1 . LEU   A 1 20  ? 42.50910 -26.90571 -13.50138 1.000 37.15929  ? 554  LEU   A CD1 1 
ATOM   129  C  CD2 . LEU   A 1 20  ? 44.76871 -27.85426 -13.97946 1.000 40.44844  ? 554  LEU   A CD2 1 
ATOM   130  N  N   . LYS   A 1 21  ? 45.76422 -23.51253 -17.12560 1.000 44.33656  ? 555  LYS   A N   1 
ATOM   131  C  CA  . LYS   A 1 21  ? 45.89545 -22.88746 -18.44483 1.000 39.87374  ? 555  LYS   A CA  1 
ATOM   132  C  C   . LYS   A 1 21  ? 44.58943 -22.94458 -19.24186 1.000 39.56277  ? 555  LYS   A C   1 
ATOM   133  O  O   . LYS   A 1 21  ? 44.60145 -22.88682 -20.47637 1.000 45.57825  ? 555  LYS   A O   1 
ATOM   134  C  CB  . LYS   A 1 21  ? 47.03060 -23.53029 -19.25228 1.000 40.75292  ? 555  LYS   A CB  1 
ATOM   135  C  CG  . LYS   A 1 21  ? 48.41148 -23.33307 -18.65889 1.000 39.62426  ? 555  LYS   A CG  1 
ATOM   136  C  CD  . LYS   A 1 21  ? 49.42946 -24.18504 -19.39344 1.000 44.02063  ? 555  LYS   A CD  1 
ATOM   137  C  CE  . LYS   A 1 21  ? 49.62032 -25.52454 -18.70815 1.000 44.86762  ? 555  LYS   A CE  1 
ATOM   138  N  NZ  . LYS   A 1 21  ? 50.55964 -26.38301 -19.47673 1.000 47.39549  ? 555  LYS   A NZ  1 
ATOM   139  N  N   . ILE   A 1 22  ? 43.44514 -23.05612 -18.55448 1.000 39.41804  ? 556  ILE   A N   1 
ATOM   140  C  CA  . ILE   A 1 22  ? 42.15796 -23.17310 -19.23614 1.000 35.55245  ? 556  ILE   A CA  1 
ATOM   141  C  C   . ILE   A 1 22  ? 41.56816 -21.82230 -19.62570 1.000 39.82780  ? 556  ILE   A C   1 
ATOM   142  O  O   . ILE   A 1 22  ? 40.43510 -21.77434 -20.12934 1.000 42.79330  ? 556  ILE   A O   1 
ATOM   143  C  CB  . ILE   A 1 22  ? 41.12945 -23.93780 -18.37321 1.000 37.77762  ? 556  ILE   A CB  1 
ATOM   144  C  CG1 . ILE   A 1 22  ? 40.89616 -23.23471 -17.04323 1.000 37.56466  ? 556  ILE   A CG1 1 
ATOM   145  C  CG2 . ILE   A 1 22  ? 41.61305 -25.37635 -18.08202 1.000 33.90103  ? 556  ILE   A CG2 1 
ATOM   146  C  CD1 . ILE   A 1 22  ? 39.71204 -23.75284 -16.28285 1.000 33.65985  ? 556  ILE   A CD1 1 
ATOM   147  N  N   . THR   A 1 23  ? 42.29909 -20.72236 -19.41770 1.000 36.96736  ? 557  THR   A N   1 
ATOM   148  C  CA  . THR   A 1 23  ? 41.82759 -19.40551 -19.82538 1.000 39.73579  ? 557  THR   A CA  1 
ATOM   149  C  C   . THR   A 1 23  ? 42.37163 -19.00655 -21.18535 1.000 35.35836  ? 557  THR   A C   1 
ATOM   150  O  O   . THR   A 1 23  ? 41.78136 -18.14324 -21.83978 1.000 36.67357  ? 557  THR   A O   1 
ATOM   151  C  CB  . THR   A 1 23  ? 42.21549 -18.33949 -18.78365 1.000 43.06101  ? 557  THR   A CB  1 
ATOM   152  O  OG1 . THR   A 1 23  ? 41.87798 -18.79785 -17.47111 1.000 43.94869  ? 557  THR   A OG1 1 
ATOM   153  C  CG2 . THR   A 1 23  ? 41.47859 -17.01361 -19.04272 1.000 40.02271  ? 557  THR   A CG2 1 
ATOM   154  N  N   . ASP   A 1 24  ? 43.46230 -19.63537 -21.63050 1.000 36.34547  ? 558  ASP   A N   1 
ATOM   155  C  CA  . ASP   A 1 24  ? 44.05930 -19.33816 -22.92624 1.000 42.09574  ? 558  ASP   A CA  1 
ATOM   156  C  C   . ASP   A 1 24  ? 43.24445 -19.97978 -24.04547 1.000 36.62389  ? 558  ASP   A C   1 
ATOM   157  O  O   . ASP   A 1 24  ? 42.91314 -21.16800 -23.97776 1.000 40.74516  ? 558  ASP   A O   1 
ATOM   158  C  CB  . ASP   A 1 24  ? 45.50200 -19.85133 -22.97079 1.000 45.02548  ? 558  ASP   A CB  1 
ATOM   159  C  CG  . ASP   A 1 24  ? 46.21724 -19.73084 -21.62990 1.000 47.37492  ? 558  ASP   A CG  1 
ATOM   160  O  OD1 . ASP   A 1 24  ? 46.15621 -18.64855 -21.00994 1.000 55.24780  ? 558  ASP   A OD1 1 
ATOM   161  O  OD2 . ASP   A 1 24  ? 46.85454 -20.71962 -21.20303 1.000 47.76533  ? 558  ASP   A OD2 1 
ATOM   162  N  N   . PHE   A 1 25  ? 42.91399 -19.18920 -25.07173 1.000 35.01656  ? 559  PHE   A N   1 
ATOM   163  C  CA  . PHE   A 1 25  ? 42.30843 -19.74443 -26.27751 1.000 32.87179  ? 559  PHE   A CA  1 
ATOM   164  C  C   . PHE   A 1 25  ? 43.20099 -20.79033 -26.93201 1.000 40.35199  ? 559  PHE   A C   1 
ATOM   165  O  O   . PHE   A 1 25  ? 42.70274 -21.64107 -27.67805 1.000 45.48682  ? 559  PHE   A O   1 
ATOM   166  C  CB  . PHE   A 1 25  ? 42.00749 -18.62798 -27.27944 1.000 35.46708  ? 559  PHE   A CB  1 
ATOM   167  C  CG  . PHE   A 1 25  ? 40.93674 -17.67468 -26.82964 1.000 38.89246  ? 559  PHE   A CG  1 
ATOM   168  C  CD1 . PHE   A 1 25  ? 39.60374 -18.05718 -26.83042 1.000 41.62005  ? 559  PHE   A CD1 1 
ATOM   169  C  CD2 . PHE   A 1 25  ? 41.26069 -16.39106 -26.41986 1.000 36.81249  ? 559  PHE   A CD2 1 
ATOM   170  C  CE1 . PHE   A 1 25  ? 38.61383 -17.17983 -26.42090 1.000 37.75581  ? 559  PHE   A CE1 1 
ATOM   171  C  CE2 . PHE   A 1 25  ? 40.27619 -15.50854 -26.01076 1.000 41.56405  ? 559  PHE   A CE2 1 
ATOM   172  C  CZ  . PHE   A 1 25  ? 38.95080 -15.90399 -26.01141 1.000 43.73303  ? 559  PHE   A CZ  1 
ATOM   173  N  N   . SER   A 1 26  ? 44.50420 -20.74519 -26.66556 1.000 41.71392  ? 560  SER   A N   1 
ATOM   174  C  CA  . SER   A 1 26  ? 45.47238 -21.67826 -27.22291 1.000 37.94404  ? 560  SER   A CA  1 
ATOM   175  C  C   . SER   A 1 26  ? 45.63046 -22.94553 -26.38782 1.000 36.86722  ? 560  SER   A C   1 
ATOM   176  O  O   . SER   A 1 26  ? 46.57645 -23.70563 -26.61688 1.000 37.62591  ? 560  SER   A O   1 
ATOM   177  C  CB  . SER   A 1 26  ? 46.83339 -20.98850 -27.36945 1.000 43.51340  ? 560  SER   A CB  1 
ATOM   178  O  OG  . SER   A 1 26  ? 47.35575 -20.63891 -26.09647 1.000 45.90224  ? 560  SER   A OG  1 
ATOM   179  N  N   . PHE   A 1 27  ? 44.73437 -23.18842 -25.43324 1.000 36.83291  ? 561  PHE   A N   1 
ATOM   180  C  CA  . PHE   A 1 27  ? 44.86135 -24.34515 -24.55382 1.000 38.32691  ? 561  PHE   A CA  1 
ATOM   181  C  C   . PHE   A 1 27  ? 44.83019 -25.64354 -25.35427 1.000 41.01464  ? 561  PHE   A C   1 
ATOM   182  O  O   . PHE   A 1 27  ? 44.09280 -25.77170 -26.33557 1.000 34.84737  ? 561  PHE   A O   1 
ATOM   183  C  CB  . PHE   A 1 27  ? 43.73972 -24.32483 -23.50662 1.000 33.28737  ? 561  PHE   A CB  1 
ATOM   184  C  CG  . PHE   A 1 27  ? 43.53270 -25.63533 -22.78353 1.000 33.35422  ? 561  PHE   A CG  1 
ATOM   185  C  CD1 . PHE   A 1 27  ? 42.72523 -26.63464 -23.31538 1.000 31.01951  ? 561  PHE   A CD1 1 
ATOM   186  C  CD2 . PHE   A 1 27  ? 44.14438 -25.86127 -21.56073 1.000 36.19664  ? 561  PHE   A CD2 1 
ATOM   187  C  CE1 . PHE   A 1 27  ? 42.54047 -27.83235 -22.64151 1.000 34.47539  ? 561  PHE   A CE1 1 
ATOM   188  C  CE2 . PHE   A 1 27  ? 43.96342 -27.05546 -20.88229 1.000 34.79491  ? 561  PHE   A CE2 1 
ATOM   189  C  CZ  . PHE   A 1 27  ? 43.16037 -28.04208 -21.42351 1.000 39.50522  ? 561  PHE   A CZ  1 
ATOM   190  N  N   . SER   A 1 28  ? 45.63960 -26.61354 -24.92580 1.000 36.17522  ? 562  SER   A N   1 
ATOM   191  C  CA  . SER   A 1 28  ? 45.65459 -27.94519 -25.51557 1.000 33.31557  ? 562  SER   A CA  1 
ATOM   192  C  C   . SER   A 1 28  ? 45.65107 -28.98455 -24.40071 1.000 40.73045  ? 562  SER   A C   1 
ATOM   193  O  O   . SER   A 1 28  ? 46.02428 -28.70078 -23.25883 1.000 41.00623  ? 562  SER   A O   1 
ATOM   194  C  CB  . SER   A 1 28  ? 46.87026 -28.14577 -26.43349 1.000 35.66469  ? 562  SER   A CB  1 
ATOM   195  O  OG  . SER   A 1 28  ? 46.94755 -29.48380 -26.89529 1.000 36.58946  ? 562  SER   A OG  1 
ATOM   196  N  N   . ASP   A 1 29  ? 45.22191 -30.20091 -24.74485 1.000 36.73641  ? 563  ASP   A N   1 
ATOM   197  C  CA  . ASP   A 1 29  ? 45.01022 -31.26238 -23.76571 1.000 34.16162  ? 563  ASP   A CA  1 
ATOM   198  C  C   . ASP   A 1 29  ? 45.82036 -32.52061 -24.05543 1.000 36.67259  ? 563  ASP   A C   1 
ATOM   199  O  O   . ASP   A 1 29  ? 45.59843 -33.54788 -23.40146 1.000 38.85020  ? 563  ASP   A O   1 
ATOM   200  C  CB  . ASP   A 1 29  ? 43.52218 -31.62532 -23.69897 1.000 38.13026  ? 563  ASP   A CB  1 
ATOM   201  C  CG  . ASP   A 1 29  ? 43.07105 -32.44518 -24.89572 1.000 37.36210  ? 563  ASP   A CG  1 
ATOM   202  O  OD1 . ASP   A 1 29  ? 43.01905 -31.88901 -26.01277 1.000 40.86018  ? 563  ASP   A OD1 1 
ATOM   203  O  OD2 . ASP   A 1 29  ? 42.77356 -33.64682 -24.72350 1.000 34.47981  ? 563  ASP   A OD2 1 
ATOM   204  N  N   . PHE   A 1 30  ? 46.75268 -32.47218 -25.00991 1.000 38.10385  ? 564  PHE   A N   1 
ATOM   205  C  CA  . PHE   A 1 30  ? 47.45998 -33.67816 -25.42781 1.000 38.20187  ? 564  PHE   A CA  1 
ATOM   206  C  C   . PHE   A 1 30  ? 48.31833 -34.27516 -24.31832 1.000 39.81929  ? 564  PHE   A C   1 
ATOM   207  O  O   . PHE   A 1 30  ? 48.61388 -35.47514 -24.35671 1.000 42.52801  ? 564  PHE   A O   1 
ATOM   208  C  CB  . PHE   A 1 30  ? 48.32981 -33.37625 -26.64973 1.000 34.62482  ? 564  PHE   A CB  1 
ATOM   209  C  CG  . PHE   A 1 30  ? 47.54518 -33.01414 -27.87833 1.000 40.43433  ? 564  PHE   A CG  1 
ATOM   210  C  CD1 . PHE   A 1 30  ? 46.31577 -33.59926 -28.12532 1.000 35.47147  ? 564  PHE   A CD1 1 
ATOM   211  C  CD2 . PHE   A 1 30  ? 48.04186 -32.09866 -28.79201 1.000 36.38416  ? 564  PHE   A CD2 1 
ATOM   212  C  CE1 . PHE   A 1 30  ? 45.59090 -33.27168 -29.25350 1.000 30.48754  ? 564  PHE   A CE1 1 
ATOM   213  C  CE2 . PHE   A 1 30  ? 47.32247 -31.76847 -29.92433 1.000 31.22072  ? 564  PHE   A CE2 1 
ATOM   214  C  CZ  . PHE   A 1 30  ? 46.09537 -32.35549 -30.15523 1.000 34.12158  ? 564  PHE   A CZ  1 
ATOM   215  N  N   . GLU   A 1 31  ? 48.72054 -33.47628 -23.33305 1.000 35.92855  ? 565  GLU   A N   1 
ATOM   216  C  CA  . GLU   A 1 31  ? 49.60204 -33.93109 -22.26758 1.000 36.57077  ? 565  GLU   A CA  1 
ATOM   217  C  C   . GLU   A 1 31  ? 48.84950 -34.27134 -20.98864 1.000 38.19178  ? 565  GLU   A C   1 
ATOM   218  O  O   . GLU   A 1 31  ? 49.47854 -34.46470 -19.94306 1.000 40.54749  ? 565  GLU   A O   1 
ATOM   219  C  CB  . GLU   A 1 31  ? 50.65547 -32.86242 -21.97426 1.000 30.01552  ? 565  GLU   A CB  1 
ATOM   220  C  CG  . GLU   A 1 31  ? 50.09433 -31.61157 -21.31018 1.000 36.30274  ? 565  GLU   A CG  1 
ATOM   221  C  CD  . GLU   A 1 31  ? 49.61725 -30.57478 -22.31006 1.000 35.87863  ? 565  GLU   A CD  1 
ATOM   222  O  OE1 . GLU   A 1 31  ? 49.30951 -30.95377 -23.45969 1.000 38.09456  ? 565  GLU   A OE1 1 
ATOM   223  O  OE2 . GLU   A 1 31  ? 49.54218 -29.38162 -21.94505 1.000 38.63639  ? 565  GLU   A OE2 1 
ATOM   224  N  N   . LEU   A 1 32  ? 47.52480 -34.35263 -21.04516 1.000 35.58893  ? 566  LEU   A N   1 
ATOM   225  C  CA  . LEU   A 1 32  ? 46.69538 -34.44139 -19.85428 1.000 32.14572  ? 566  LEU   A CA  1 
ATOM   226  C  C   . LEU   A 1 32  ? 46.10559 -35.83665 -19.71320 1.000 35.96791  ? 566  LEU   A C   1 
ATOM   227  O  O   . LEU   A 1 32  ? 45.68418 -36.44964 -20.70041 1.000 35.04327  ? 566  LEU   A O   1 
ATOM   228  C  CB  . LEU   A 1 32  ? 45.56891 -33.40676 -19.90131 1.000 29.99380  ? 566  LEU   A CB  1 
ATOM   229  C  CG  . LEU   A 1 32  ? 46.01392 -31.94258 -19.87586 1.000 31.45412  ? 566  LEU   A CG  1 
ATOM   230  C  CD1 . LEU   A 1 32  ? 44.83190 -31.03075 -19.59909 1.000 29.86407  ? 566  LEU   A CD1 1 
ATOM   231  C  CD2 . LEU   A 1 32  ? 47.11752 -31.72184 -18.84713 1.000 33.84528  ? 566  LEU   A CD2 1 
ATOM   232  N  N   . SER   A 1 33  ? 46.08253 -36.33192 -18.47957 1.000 34.31981  ? 567  SER   A N   1 
ATOM   233  C  CA  . SER   A 1 33  ? 45.35799 -37.55369 -18.17780 1.000 32.97593  ? 567  SER   A CA  1 
ATOM   234  C  C   . SER   A 1 33  ? 43.85493 -37.28624 -18.18821 1.000 36.14891  ? 567  SER   A C   1 
ATOM   235  O  O   . SER   A 1 33  ? 43.40072 -36.13799 -18.16809 1.000 34.06369  ? 567  SER   A O   1 
ATOM   236  C  CB  . SER   A 1 33  ? 45.77965 -38.10446 -16.81514 1.000 33.89071  ? 567  SER   A CB  1 
ATOM   237  O  OG  . SER   A 1 33  ? 45.46352 -37.18806 -15.77744 1.000 34.65431  ? 567  SER   A OG  1 
ATOM   238  N  N   . ASP   A 1 34  ? 43.07531 -38.37074 -18.22886 1.000 33.36453  ? 568  ASP   A N   1 
ATOM   239  C  CA  . ASP   A 1 34  ? 41.62909 -38.23432 -18.08330 1.000 35.55935  ? 568  ASP   A CA  1 
ATOM   240  C  C   . ASP   A 1 34  ? 41.26901 -37.60573 -16.74236 1.000 38.58079  ? 568  ASP   A C   1 
ATOM   241  O  O   . ASP   A 1 34  ? 40.26444 -36.89170 -16.63662 1.000 40.61062  ? 568  ASP   A O   1 
ATOM   242  C  CB  . ASP   A 1 34  ? 40.95049 -39.59825 -18.23222 1.000 35.76060  ? 568  ASP   A CB  1 
ATOM   243  C  CG  . ASP   A 1 34  ? 40.64071 -39.94893 -19.67689 1.000 42.04932  ? 568  ASP   A CG  1 
ATOM   244  O  OD1 . ASP   A 1 34  ? 41.06706 -39.20602 -20.58514 1.000 38.60891  ? 568  ASP   A OD1 1 
ATOM   245  O  OD2 . ASP   A 1 34  ? 39.96238 -40.97316 -19.90174 1.000 45.70663  ? 568  ASP   A OD2 1 
ATOM   246  N  N   . LEU   A 1 35  ? 42.08470 -37.84767 -15.71339 1.000 37.02431  ? 569  LEU   A N   1 
ATOM   247  C  CA  . LEU   A 1 35  ? 41.85240 -37.22518 -14.41449 1.000 32.19900  ? 569  LEU   A CA  1 
ATOM   248  C  C   . LEU   A 1 35  ? 42.10749 -35.72312 -14.46447 1.000 34.15360  ? 569  LEU   A C   1 
ATOM   249  O  O   . LEU   A 1 35  ? 41.37461 -34.94187 -13.84563 1.000 39.17079  ? 569  LEU   A O   1 
ATOM   250  C  CB  . LEU   A 1 35  ? 42.73887 -37.88226 -13.35853 1.000 38.87038  ? 569  LEU   A CB  1 
ATOM   251  C  CG  . LEU   A 1 35  ? 42.54800 -37.40670 -11.91836 1.000 40.96311  ? 569  LEU   A CG  1 
ATOM   252  C  CD1 . LEU   A 1 35  ? 41.49909 -38.25242 -11.21126 1.000 45.74316  ? 569  LEU   A CD1 1 
ATOM   253  C  CD2 . LEU   A 1 35  ? 43.87032 -37.44132 -11.17249 1.000 35.16098  ? 569  LEU   A CD2 1 
ATOM   254  N  N   . GLU   A 1 36  ? 43.14420 -35.30019 -15.19249 1.000 35.93248  ? 570  GLU   A N   1 
ATOM   255  C  CA  . GLU   A 1 36  ? 43.45470 -33.87648 -15.27814 1.000 31.66614  ? 570  GLU   A CA  1 
ATOM   256  C  C   . GLU   A 1 36  ? 42.34368 -33.10550 -15.98038 1.000 31.53164  ? 570  GLU   A C   1 
ATOM   257  O  O   . GLU   A 1 36  ? 42.00918 -31.98648 -15.57600 1.000 33.48569  ? 570  GLU   A O   1 
ATOM   258  C  CB  . GLU   A 1 36  ? 44.78545 -33.66951 -15.99992 1.000 33.45146  ? 570  GLU   A CB  1 
ATOM   259  C  CG  . GLU   A 1 36  ? 45.97088 -33.50496 -15.06668 1.000 36.67939  ? 570  GLU   A CG  1 
ATOM   260  C  CD  . GLU   A 1 36  ? 47.27418 -33.94730 -15.69618 1.000 38.59132  ? 570  GLU   A CD  1 
ATOM   261  O  OE1 . GLU   A 1 36  ? 47.24462 -34.86220 -16.54463 1.000 36.98384  ? 570  GLU   A OE1 1 
ATOM   262  O  OE2 . GLU   A 1 36  ? 48.32837 -33.38068 -15.33940 1.000 35.30430  ? 570  GLU   A OE2 1 
ATOM   263  N  N   . THR   A 1 37  ? 41.76533 -33.68305 -17.03842 1.000 28.16204  ? 571  THR   A N   1 
ATOM   264  C  CA  . THR   A 1 37  ? 40.63901 -33.04041 -17.70639 1.000 30.74972  ? 571  THR   A CA  1 
ATOM   265  C  C   . THR   A 1 37  ? 39.44599 -32.91108 -16.77146 1.000 29.62408  ? 571  THR   A C   1 
ATOM   266  O  O   . THR   A 1 37  ? 38.68066 -31.94553 -16.87092 1.000 29.55278  ? 571  THR   A O   1 
ATOM   267  C  CB  . THR   A 1 37  ? 40.23975 -33.82472 -18.95506 1.000 30.10850  ? 571  THR   A CB  1 
ATOM   268  O  OG1 . THR   A 1 37  ? 39.90053 -35.16479 -18.58476 1.000 32.43874  ? 571  THR   A OG1 1 
ATOM   269  C  CG2 . THR   A 1 37  ? 41.38621 -33.85876 -19.95349 1.000 27.21798  ? 571  THR   A CG2 1 
ATOM   270  N  N   . ALA   A 1 38  ? 39.26552 -33.86968 -15.86036 1.000 34.64033  ? 572  ALA   A N   1 
ATOM   271  C  CA  . ALA   A 1 38  ? 38.18009 -33.76063 -14.89238 1.000 33.37490  ? 572  ALA   A CA  1 
ATOM   272  C  C   . ALA   A 1 38  ? 38.41886 -32.59782 -13.93814 1.000 34.14341  ? 572  ALA   A C   1 
ATOM   273  O  O   . ALA   A 1 38  ? 37.49442 -31.84240 -13.61748 1.000 41.18189  ? 572  ALA   A O   1 
ATOM   274  C  CB  . ALA   A 1 38  ? 38.02755 -35.07098 -14.12349 1.000 39.60582  ? 572  ALA   A CB  1 
ATOM   275  N  N   . LEU   A 1 39  ? 39.66050 -32.43973 -13.47162 1.000 37.38162  ? 573  LEU   A N   1 
ATOM   276  C  CA  . LEU   A 1 39  ? 39.98426 -31.32089 -12.59083 1.000 35.62811  ? 573  LEU   A CA  1 
ATOM   277  C  C   . LEU   A 1 39  ? 39.79764 -29.98360 -13.29863 1.000 36.77909  ? 573  LEU   A C   1 
ATOM   278  O  O   . LEU   A 1 39  ? 39.26515 -29.03340 -12.71304 1.000 35.48884  ? 573  LEU   A O   1 
ATOM   279  C  CB  . LEU   A 1 39  ? 41.41332 -31.46429 -12.06748 1.000 36.08548  ? 573  LEU   A CB  1 
ATOM   280  C  CG  . LEU   A 1 39  ? 41.72873 -32.71994 -11.25521 1.000 44.12602  ? 573  LEU   A CG  1 
ATOM   281  C  CD1 . LEU   A 1 39  ? 43.21498 -32.79396 -10.95666 1.000 39.39459  ? 573  LEU   A CD1 1 
ATOM   282  C  CD2 . LEU   A 1 39  ? 40.93041 -32.70892 -9.97010  1.000 48.38466  ? 573  LEU   A CD2 1 
ATOM   283  N  N   . CYS   A 1 40  ? 40.22445 -29.89266 -14.56188 1.000 37.97767  ? 574  CYS   A N   1 
ATOM   284  C  CA  . CYS   A 1 40  ? 39.99650 -28.67789 -15.33636 1.000 31.81804  ? 574  CYS   A CA  1 
ATOM   285  C  C   . CYS   A 1 40  ? 38.51100 -28.37243 -15.46400 1.000 30.48474  ? 574  CYS   A C   1 
ATOM   286  O  O   . CYS   A 1 40  ? 38.12006 -27.20040 -15.49052 1.000 34.60071  ? 574  CYS   A O   1 
ATOM   287  C  CB  . CYS   A 1 40  ? 40.63655 -28.80535 -16.72013 1.000 32.37307  ? 574  CYS   A CB  1 
ATOM   288  S  SG  . CYS   A 1 40  ? 42.43535 -29.05965 -16.71545 1.000 37.96580  ? 574  CYS   A SG  1 
ATOM   289  N  N   . THR   A 1 41  ? 37.66993 -29.40916 -15.52520 1.000 30.49901  ? 575  THR   A N   1 
ATOM   290  C  CA  . THR   A 1 41  ? 36.23182 -29.19478 -15.65815 1.000 35.83882  ? 575  THR   A CA  1 
ATOM   291  C  C   . THR   A 1 41  ? 35.62388 -28.67663 -14.35838 1.000 38.36936  ? 575  THR   A C   1 
ATOM   292  O  O   . THR   A 1 41  ? 34.76528 -27.78542 -14.38156 1.000 36.68565  ? 575  THR   A O   1 
ATOM   293  C  CB  . THR   A 1 41  ? 35.54409 -30.49079 -16.08948 1.000 34.53699  ? 575  THR   A CB  1 
ATOM   294  O  OG1 . THR   A 1 41  ? 36.25866 -31.07927 -17.18420 1.000 33.89415  ? 575  THR   A OG1 1 
ATOM   295  C  CG2 . THR   A 1 41  ? 34.11272 -30.21552 -16.51687 1.000 30.95493  ? 575  THR   A CG2 1 
ATOM   296  N  N   . ILE   A 1 42  ? 36.04880 -29.22803 -13.21619 1.000 34.22839  ? 576  ILE   A N   1 
ATOM   297  C  CA  . ILE   A 1 42  ? 35.58246 -28.72254 -11.92593 1.000 33.95229  ? 576  ILE   A CA  1 
ATOM   298  C  C   . ILE   A 1 42  ? 35.97146 -27.25846 -11.76462 1.000 37.61182  ? 576  ILE   A C   1 
ATOM   299  O  O   . ILE   A 1 42  ? 35.17159 -26.42965 -11.31143 1.000 36.19372  ? 576  ILE   A O   1 
ATOM   300  C  CB  . ILE   A 1 42  ? 36.13845 -29.58276 -10.77281 1.000 33.44669  ? 576  ILE   A CB  1 
ATOM   301  C  CG1 . ILE   A 1 42  ? 35.56984 -31.00207 -10.81869 1.000 33.04114  ? 576  ILE   A CG1 1 
ATOM   302  C  CG2 . ILE   A 1 42  ? 35.82539 -28.93851 -9.43097  1.000 32.21539  ? 576  ILE   A CG2 1 
ATOM   303  C  CD1 . ILE   A 1 42  ? 36.33392 -31.99648 -9.95874  1.000 32.36973  ? 576  ILE   A CD1 1 
ATOM   304  N  N   . ARG   A 1 43  ? 37.20620 -26.91905 -12.14575 1.000 38.00696  ? 577  ARG   A N   1 
ATOM   305  C  CA  . ARG   A 1 43  ? 37.66555 -25.53608 -12.08632 1.000 35.74315  ? 577  ARG   A CA  1 
ATOM   306  C  C   . ARG   A 1 43  ? 36.80564 -24.62640 -12.95510 1.000 33.95097  ? 577  ARG   A C   1 
ATOM   307  O  O   . ARG   A 1 43  ? 36.57197 -23.46614 -12.59569 1.000 35.76908  ? 577  ARG   A O   1 
ATOM   308  C  CB  . ARG   A 1 43  ? 39.13499 -25.46283 -12.50754 1.000 33.97060  ? 577  ARG   A CB  1 
ATOM   309  C  CG  . ARG   A 1 43  ? 39.68443 -24.06069 -12.70070 1.000 33.16708  ? 577  ARG   A CG  1 
ATOM   310  C  CD  . ARG   A 1 43  ? 39.53367 -23.21739 -11.44703 1.000 33.93488  ? 577  ARG   A CD  1 
ATOM   311  N  NE  . ARG   A 1 43  ? 39.99220 -23.90790 -10.24666 1.000 35.20417  ? 577  ARG   A NE  1 
ATOM   312  C  CZ  . ARG   A 1 43  ? 39.90948 -23.40706 -9.02194  1.000 32.18233  ? 577  ARG   A CZ  1 
ATOM   313  N  NH1 . ARG   A 1 43  ? 39.38992 -22.21130 -8.79796  1.000 39.23173  ? 577  ARG   A NH1 1 
ATOM   314  N  NH2 . ARG   A 1 43  ? 40.35758 -24.12366 -7.99687  1.000 27.62464  ? 577  ARG   A NH2 1 
ATOM   315  N  N   . MET   A 1 44  ? 36.31018 -25.13594 -14.08671 1.000 31.82172  ? 578  MET   A N   1 
ATOM   316  C  CA  . MET   A 1 44  ? 35.42531 -24.34131 -14.93562 1.000 36.53300  ? 578  MET   A CA  1 
ATOM   317  C  C   . MET   A 1 44  ? 34.12171 -24.01568 -14.21529 1.000 36.17808  ? 578  MET   A C   1 
ATOM   318  O  O   . MET   A 1 44  ? 33.69591 -22.85560 -14.16782 1.000 38.66781  ? 578  MET   A O   1 
ATOM   319  C  CB  . MET   A 1 44  ? 35.14994 -25.08592 -16.24329 1.000 33.50446  ? 578  MET   A CB  1 
ATOM   320  C  CG  . MET   A 1 44  ? 36.36018 -25.22010 -17.15665 1.000 30.17984  ? 578  MET   A CG  1 
ATOM   321  S  SD  . MET   A 1 44  ? 35.92832 -25.79924 -18.80656 1.000 40.46541  ? 578  MET   A SD  1 
ATOM   322  C  CE  . MET   A 1 44  ? 37.25925 -26.96050 -19.09033 1.000 29.00537  ? 578  MET   A CE  1 
ATOM   323  N  N   . PHE   A 1 45  ? 33.47264 -25.03566 -13.64854 1.000 35.61789  ? 579  PHE   A N   1 
ATOM   324  C  CA  . PHE   A 1 45  ? 32.26184 -24.80694 -12.86700 1.000 33.79500  ? 579  PHE   A CA  1 
ATOM   325  C  C   . PHE   A 1 45  ? 32.53910 -23.88223 -11.68969 1.000 35.28169  ? 579  PHE   A C   1 
ATOM   326  O  O   . PHE   A 1 45  ? 31.74232 -22.98434 -11.39115 1.000 37.95824  ? 579  PHE   A O   1 
ATOM   327  C  CB  . PHE   A 1 45  ? 31.69993 -26.13723 -12.36424 1.000 33.25057  ? 579  PHE   A CB  1 
ATOM   328  C  CG  . PHE   A 1 45  ? 30.92731 -26.90397 -13.39699 1.000 35.63775  ? 579  PHE   A CG  1 
ATOM   329  C  CD1 . PHE   A 1 45  ? 29.59599 -26.61206 -13.64944 1.000 37.98635  ? 579  PHE   A CD1 1 
ATOM   330  C  CD2 . PHE   A 1 45  ? 31.53059 -27.92444 -14.11049 1.000 31.71069  ? 579  PHE   A CD2 1 
ATOM   331  C  CE1 . PHE   A 1 45  ? 28.88356 -27.32473 -14.59544 1.000 36.11381  ? 579  PHE   A CE1 1 
ATOM   332  C  CE2 . PHE   A 1 45  ? 30.82364 -28.63871 -15.05767 1.000 35.47131  ? 579  PHE   A CE2 1 
ATOM   333  C  CZ  . PHE   A 1 45  ? 29.49797 -28.33731 -15.29970 1.000 36.78137  ? 579  PHE   A CZ  1 
ATOM   334  N  N   . THR   A 1 46  ? 33.67537 -24.08069 -11.01626 1.000 40.32590  ? 580  THR   A N   1 
ATOM   335  C  CA  . THR   A 1 46  ? 33.97723 -23.31225 -9.81270  1.000 35.87515  ? 580  THR   A CA  1 
ATOM   336  C  C   . THR   A 1 46  ? 34.22356 -21.84344 -10.13912 1.000 38.55725  ? 580  THR   A C   1 
ATOM   337  O  O   . THR   A 1 46  ? 33.62672 -20.95221 -9.52375  1.000 40.01637  ? 580  THR   A O   1 
ATOM   338  C  CB  . THR   A 1 46  ? 35.18960 -23.91385 -9.09965  1.000 34.16111  ? 580  THR   A CB  1 
ATOM   339  O  OG1 . THR   A 1 46  ? 35.08538 -25.34419 -9.09602  1.000 34.42114  ? 580  THR   A OG1 1 
ATOM   340  C  CG2 . THR   A 1 46  ? 35.27101 -23.40772 -7.66701  1.000 28.46929  ? 580  THR   A CG2 1 
ATOM   341  N  N   . ASP   A 1 47  ? 35.09676 -21.56948 -11.11068 1.000 41.64394  ? 581  ASP   A N   1 
ATOM   342  C  CA  . ASP   A 1 47  ? 35.48599 -20.19520 -11.40474 1.000 39.83963  ? 581  ASP   A CA  1 
ATOM   343  C  C   . ASP   A 1 47  ? 34.44947 -19.43841 -12.22333 1.000 40.96387  ? 581  ASP   A C   1 
ATOM   344  O  O   . ASP   A 1 47  ? 34.60443 -18.22733 -12.41799 1.000 38.94332  ? 581  ASP   A O   1 
ATOM   345  C  CB  . ASP   A 1 47  ? 36.83808 -20.17015 -12.11940 1.000 35.89777  ? 581  ASP   A CB  1 
ATOM   346  C  CG  . ASP   A 1 47  ? 38.00204 -20.25422 -11.15149 1.000 37.56296  ? 581  ASP   A CG  1 
ATOM   347  O  OD1 . ASP   A 1 47  ? 37.79990 -20.75807 -10.02567 1.000 37.66081  ? 581  ASP   A OD1 1 
ATOM   348  O  OD2 . ASP   A 1 47  ? 39.11609 -19.81882 -11.51051 1.000 47.41344  ? 581  ASP   A OD2 1 
ATOM   349  N  N   . LEU   A 1 48  ? 33.41265 -20.11296 -12.71231 1.000 38.63851  ? 582  LEU   A N   1 
ATOM   350  C  CA  . LEU   A 1 48  ? 32.23157 -19.44142 -13.23226 1.000 37.21936  ? 582  LEU   A CA  1 
ATOM   351  C  C   . LEU   A 1 48  ? 31.16542 -19.25910 -12.16221 1.000 41.85255  ? 582  LEU   A C   1 
ATOM   352  O  O   . LEU   A 1 48  ? 30.04070 -18.86024 -12.48262 1.000 46.34928  ? 582  LEU   A O   1 
ATOM   353  C  CB  . LEU   A 1 48  ? 31.65524 -20.21377 -14.42109 1.000 38.70332  ? 582  LEU   A CB  1 
ATOM   354  C  CG  . LEU   A 1 48  ? 32.46930 -20.12717 -15.71498 1.000 37.42830  ? 582  LEU   A CG  1 
ATOM   355  C  CD1 . LEU   A 1 48  ? 32.18990 -21.31109 -16.63569 1.000 34.16585  ? 582  LEU   A CD1 1 
ATOM   356  C  CD2 . LEU   A 1 48  ? 32.20610 -18.80732 -16.42450 1.000 35.39701  ? 582  LEU   A CD2 1 
ATOM   357  N  N   . ASN   A 1 49  ? 31.49927 -19.55483 -10.90443 1.000 45.35684  ? 583  ASN   A N   1 
ATOM   358  C  CA  . ASN   A 1 49  ? 30.60225 -19.43067 -9.75762  1.000 41.20555  ? 583  ASN   A CA  1 
ATOM   359  C  C   . ASN   A 1 49  ? 29.37156 -20.32401 -9.88282  1.000 43.31198  ? 583  ASN   A C   1 
ATOM   360  O  O   . ASN   A 1 49  ? 28.33111 -20.03938 -9.28147  1.000 49.57444  ? 583  ASN   A O   1 
ATOM   361  C  CB  . ASN   A 1 49  ? 30.18486 -17.97081 -9.53667  1.000 36.48057  ? 583  ASN   A CB  1 
ATOM   362  C  CG  . ASN   A 1 49  ? 31.35613 -17.00642 -9.64695  1.000 48.35493  ? 583  ASN   A CG  1 
ATOM   363  O  OD1 . ASN   A 1 49  ? 31.30769 -16.03802 -10.40470 1.000 52.72497  ? 583  ASN   A OD1 1 
ATOM   364  N  ND2 . ASN   A 1 49  ? 32.41623 -17.27166 -8.89339  1.000 44.22499  ? 583  ASN   A ND2 1 
ATOM   365  N  N   . LEU   A 1 50  ? 29.47420 -21.41527 -10.64562 1.000 39.87727  ? 584  LEU   A N   1 
ATOM   366  C  CA  . LEU   A 1 50  ? 28.33265 -22.30393 -10.83537 1.000 40.90297  ? 584  LEU   A CA  1 
ATOM   367  C  C   . LEU   A 1 50  ? 28.14003 -23.23259 -9.64298  1.000 42.09723  ? 584  LEU   A C   1 
ATOM   368  O  O   . LEU   A 1 50  ? 27.00174 -23.52679 -9.26250  1.000 43.37735  ? 584  LEU   A O   1 
ATOM   369  C  CB  . LEU   A 1 50  ? 28.51053 -23.11197 -12.12116 1.000 39.31866  ? 584  LEU   A CB  1 
ATOM   370  C  CG  . LEU   A 1 50  ? 28.59080 -22.28773 -13.41009 1.000 38.43637  ? 584  LEU   A CG  1 
ATOM   371  C  CD1 . LEU   A 1 50  ? 28.51601 -23.18086 -14.63758 1.000 36.85450  ? 584  LEU   A CD1 1 
ATOM   372  C  CD2 . LEU   A 1 50  ? 27.49620 -21.22902 -13.44778 1.000 40.44792  ? 584  LEU   A CD2 1 
ATOM   373  N  N   . VAL   A 1 51  ? 29.23691 -23.70124 -9.04356  1.000 39.30238  ? 585  VAL   A N   1 
ATOM   374  C  CA  . VAL   A 1 51  ? 29.13195 -24.55087 -7.86104  1.000 42.82725  ? 585  VAL   A CA  1 
ATOM   375  C  C   . VAL   A 1 51  ? 28.51708 -23.77417 -6.70309  1.000 43.00876  ? 585  VAL   A C   1 
ATOM   376  O  O   . VAL   A 1 51  ? 27.73882 -24.32002 -5.91094  1.000 40.28063  ? 585  VAL   A O   1 
ATOM   377  C  CB  . VAL   A 1 51  ? 30.51571 -25.12368 -7.49755  1.000 36.24379  ? 585  VAL   A CB  1 
ATOM   378  C  CG1 . VAL   A 1 51  ? 30.48403 -25.81097 -6.13344  1.000 38.99605  ? 585  VAL   A CG1 1 
ATOM   379  C  CG2 . VAL   A 1 51  ? 30.99253 -26.08545 -8.57809  1.000 29.94791  ? 585  VAL   A CG2 1 
ATOM   380  N  N   . GLN   A 1 52  ? 28.83285 -22.48210 -6.60561  1.000 42.35937  ? 586  GLN   A N   1 
ATOM   381  C  CA  . GLN   A 1 52  ? 28.37685 -21.66240 -5.48779  1.000 42.61415  ? 586  GLN   A CA  1 
ATOM   382  C  C   . GLN   A 1 52  ? 26.94521 -21.18071 -5.68865  1.000 46.06728  ? 586  GLN   A C   1 
ATOM   383  O  O   . GLN   A 1 52  ? 26.07905 -21.40687 -4.83777  1.000 48.36911  ? 586  GLN   A O   1 
ATOM   384  C  CB  . GLN   A 1 52  ? 29.31701 -20.46917 -5.30235  1.000 42.27917  ? 586  GLN   A CB  1 
ATOM   385  C  CG  . GLN   A 1 52  ? 29.44774 -20.00100 -3.86412  1.000 47.37655  ? 586  GLN   A CG  1 
ATOM   386  C  CD  . GLN   A 1 52  ? 28.47361 -18.89067 -3.52326  1.000 48.92100  ? 586  GLN   A CD  1 
ATOM   387  O  OE1 . GLN   A 1 52  ? 28.29869 -17.94476 -4.29081  1.000 62.38944  ? 586  GLN   A OE1 1 
ATOM   388  N  NE2 . GLN   A 1 52  ? 27.83461 -18.99987 -2.36656  1.000 48.22031  ? 586  GLN   A NE2 1 
ATOM   389  N  N   . ASN   A 1 53  ? 26.68396 -20.50328 -6.81013  1.000 41.23319  ? 587  ASN   A N   1 
ATOM   390  C  CA  . ASN   A 1 53  ? 25.37143 -19.90991 -7.04492  1.000 41.23239  ? 587  ASN   A CA  1 
ATOM   391  C  C   . ASN   A 1 53  ? 24.25550 -20.94458 -7.09280  1.000 43.35260  ? 587  ASN   A C   1 
ATOM   392  O  O   . ASN   A 1 53  ? 23.09231 -20.59221 -6.86882  1.000 51.95789  ? 587  ASN   A O   1 
ATOM   393  C  CB  . ASN   A 1 53  ? 25.37456 -19.11459 -8.35090  1.000 38.44546  ? 587  ASN   A CB  1 
ATOM   394  C  CG  . ASN   A 1 53  ? 26.35638 -17.96174 -8.33050  1.000 44.13453  ? 587  ASN   A CG  1 
ATOM   395  O  OD1 . ASN   A 1 53  ? 26.97212 -17.67345 -7.30535  1.000 50.10701  ? 587  ASN   A OD1 1 
ATOM   396  N  ND2 . ASN   A 1 53  ? 26.51368 -17.29925 -9.47067  1.000 42.52771  ? 587  ASN   A ND2 1 
ATOM   397  N  N   . PHE   A 1 54  ? 24.57201 -22.20531 -7.38397  1.000 45.09734  ? 588  PHE   A N   1 
ATOM   398  C  CA  . PHE   A 1 54  ? 23.54853 -23.23346 -7.51307  1.000 45.78311  ? 588  PHE   A CA  1 
ATOM   399  C  C   . PHE   A 1 54  ? 23.75365 -24.39560 -6.55051  1.000 44.78908  ? 588  PHE   A C   1 
ATOM   400  O  O   . PHE   A 1 54  ? 23.10694 -25.43850 -6.71075  1.000 43.29073  ? 588  PHE   A O   1 
ATOM   401  C  CB  . PHE   A 1 54  ? 23.48524 -23.72612 -8.95947  1.000 39.11462  ? 588  PHE   A CB  1 
ATOM   402  C  CG  . PHE   A 1 54  ? 23.31127 -22.61130 -9.95135  1.000 43.75224  ? 588  PHE   A CG  1 
ATOM   403  C  CD1 . PHE   A 1 54  ? 22.08641 -21.98016 -10.09376 1.000 38.61819  ? 588  PHE   A CD1 1 
ATOM   404  C  CD2 . PHE   A 1 54  ? 24.38072 -22.16861 -10.71277 1.000 40.04902  ? 588  PHE   A CD2 1 
ATOM   405  C  CE1 . PHE   A 1 54  ? 21.92814 -20.94322 -10.98917 1.000 36.76235  ? 588  PHE   A CE1 1 
ATOM   406  C  CE2 . PHE   A 1 54  ? 24.22716 -21.13200 -11.60984 1.000 35.37992  ? 588  PHE   A CE2 1 
ATOM   407  C  CZ  . PHE   A 1 54  ? 23.00001 -20.51967 -11.74878 1.000 40.16645  ? 588  PHE   A CZ  1 
ATOM   408  N  N   . GLN   A 1 55  ? 24.63400 -24.24272 -5.56159  1.000 46.36696  ? 589  GLN   A N   1 
ATOM   409  C  CA  . GLN   A 1 55  ? 24.76194 -25.16677 -4.43380  1.000 47.70047  ? 589  GLN   A CA  1 
ATOM   410  C  C   . GLN   A 1 55  ? 24.96657 -26.60654 -4.90262  1.000 47.48987  ? 589  GLN   A C   1 
ATOM   411  O  O   . GLN   A 1 55  ? 24.17952 -27.50718 -4.60727  1.000 53.50333  ? 589  GLN   A O   1 
ATOM   412  C  CB  . GLN   A 1 55  ? 23.54750 -25.06205 -3.51155  1.000 49.67914  ? 589  GLN   A CB  1 
ATOM   413  C  CG  . GLN   A 1 55  ? 23.21407 -23.64280 -3.08743  1.000 44.91331  ? 589  GLN   A CG  1 
ATOM   414  C  CD  . GLN   A 1 55  ? 21.95882 -23.11704 -3.75581  1.000 63.46658  ? 589  GLN   A CD  1 
ATOM   415  O  OE1 . GLN   A 1 55  ? 20.86498 -23.64282 -3.55411  1.000 72.25483  ? 589  GLN   A OE1 1 
ATOM   416  N  NE2 . GLN   A 1 55  ? 22.11255 -22.07033 -4.55859  1.000 66.21905  ? 589  GLN   A NE2 1 
ATOM   417  N  N   . MET   A 1 56  ? 26.05680 -26.81236 -5.63541  1.000 40.34398  ? 590  MET   A N   1 
ATOM   418  C  CA  . MET   A 1 56  ? 26.41163 -28.13227 -6.13909  1.000 42.02057  ? 590  MET   A CA  1 
ATOM   419  C  C   . MET   A 1 56  ? 27.28698 -28.85358 -5.12133  1.000 42.04255  ? 590  MET   A C   1 
ATOM   420  O  O   . MET   A 1 56  ? 28.35642 -28.35707 -4.75038  1.000 46.62194  ? 590  MET   A O   1 
ATOM   421  C  CB  . MET   A 1 56  ? 27.13577 -28.02503 -7.47820  1.000 40.70798  ? 590  MET   A CB  1 
ATOM   422  C  CG  . MET   A 1 56  ? 26.31706 -27.38628 -8.57890  1.000 39.70537  ? 590  MET   A CG  1 
ATOM   423  S  SD  . MET   A 1 56  ? 27.18865 -27.38961 -10.15577 1.000 36.13104  ? 590  MET   A SD  1 
ATOM   424  C  CE  . MET   A 1 56  ? 26.24963 -26.15697 -11.04705 1.000 38.14215  ? 590  MET   A CE  1 
ATOM   425  N  N   . LYS   A 1 57  ? 26.83437 -30.02184 -4.67487  1.000 45.93138  ? 591  LYS   A N   1 
ATOM   426  C  CA  . LYS   A 1 57  ? 27.65898 -30.86006 -3.81776  1.000 42.33820  ? 591  LYS   A CA  1 
ATOM   427  C  C   . LYS   A 1 57  ? 28.84696 -31.39192 -4.60897  1.000 46.45425  ? 591  LYS   A C   1 
ATOM   428  O  O   . LYS   A 1 57  ? 28.71377 -31.78640 -5.77095  1.000 49.70556  ? 591  LYS   A O   1 
ATOM   429  C  CB  . LYS   A 1 57  ? 26.83749 -32.01684 -3.24628  1.000 56.95760  ? 591  LYS   A CB  1 
ATOM   430  C  CG  . LYS   A 1 57  ? 26.00062 -31.65179 -2.02893  1.000 59.01751  ? 591  LYS   A CG  1 
ATOM   431  C  CD  . LYS   A 1 57  ? 25.57209 -32.89350 -1.25606  1.000 60.37148  ? 591  LYS   A CD  1 
ATOM   432  C  CE  . LYS   A 1 57  ? 24.86046 -32.52539 0.04136   1.000 65.46766  ? 591  LYS   A CE  1 
ATOM   433  N  NZ  . LYS   A 1 57  ? 23.67285 -31.65572 -0.19256  1.000 74.72608  ? 591  LYS   A NZ  1 
ATOM   434  N  N   . HIS   A 1 58  ? 30.01936 -31.38881 -3.97225  1.000 44.77626  ? 592  HIS   A N   1 
ATOM   435  C  CA  . HIS   A 1 58  ? 31.24998 -31.74512 -4.67311  1.000 38.25583  ? 592  HIS   A CA  1 
ATOM   436  C  C   . HIS   A 1 58  ? 31.18035 -33.15629 -5.24453  1.000 44.98343  ? 592  HIS   A C   1 
ATOM   437  O  O   . HIS   A 1 58  ? 31.51615 -33.38066 -6.41354  1.000 48.54451  ? 592  HIS   A O   1 
ATOM   438  C  CB  . HIS   A 1 58  ? 32.44610 -31.60588 -3.73246  1.000 43.15290  ? 592  HIS   A CB  1 
ATOM   439  C  CG  . HIS   A 1 58  ? 33.77092 -31.73971 -4.41785  1.000 41.53322  ? 592  HIS   A CG  1 
ATOM   440  N  ND1 . HIS   A 1 58  ? 34.20035 -30.85970 -5.38806  1.000 43.29904  ? 592  HIS   A ND1 1 
ATOM   441  C  CD2 . HIS   A 1 58  ? 34.75321 -32.66307 -4.28675  1.000 44.69904  ? 592  HIS   A CD2 1 
ATOM   442  C  CE1 . HIS   A 1 58  ? 35.39392 -31.22905 -5.81774  1.000 44.00154  ? 592  HIS   A CE1 1 
ATOM   443  N  NE2 . HIS   A 1 58  ? 35.75193 -32.32086 -5.16600  1.000 45.13966  ? 592  HIS   A NE2 1 
ATOM   444  N  N   . GLU   A 1 59  ? 30.74760 -34.12361 -4.42986  1.000 46.28938  ? 593  GLU   A N   1 
ATOM   445  C  CA  . GLU   A 1 59  ? 30.71023 -35.51408 -4.87619  1.000 40.97569  ? 593  GLU   A CA  1 
ATOM   446  C  C   . GLU   A 1 59  ? 29.76852 -35.70518 -6.05835  1.000 39.23611  ? 593  GLU   A C   1 
ATOM   447  O  O   . GLU   A 1 59  ? 29.99183 -36.59001 -6.89313  1.000 41.61125  ? 593  GLU   A O   1 
ATOM   448  C  CB  . GLU   A 1 59  ? 30.29623 -36.42659 -3.71970  1.000 47.73763  ? 593  GLU   A CB  1 
ATOM   449  C  CG  . GLU   A 1 59  ? 29.13082 -35.89176 -2.90256  1.000 50.96467  ? 593  GLU   A CG  1 
ATOM   450  C  CD  . GLU   A 1 59  ? 29.58130 -35.10911 -1.68088  1.000 63.16785  ? 593  GLU   A CD  1 
ATOM   451  O  OE1 . GLU   A 1 59  ? 30.22333 -34.04957 -1.84704  1.000 55.13013  ? 593  GLU   A OE1 1 
ATOM   452  O  OE2 . GLU   A 1 59  ? 29.28478 -35.54775 -0.55105  1.000 72.78781  ? 593  GLU   A OE2 1 
ATOM   453  N  N   . VAL   A 1 60  ? 28.71937 -34.88673 -6.15086  1.000 41.35642  ? 594  VAL   A N   1 
ATOM   454  C  CA  . VAL   A 1 60  ? 27.76532 -35.01671 -7.24842  1.000 42.80813  ? 594  VAL   A CA  1 
ATOM   455  C  C   . VAL   A 1 60  ? 28.38065 -34.52095 -8.55121  1.000 40.27806  ? 594  VAL   A C   1 
ATOM   456  O  O   . VAL   A 1 60  ? 28.25398 -35.16411 -9.59971  1.000 39.35298  ? 594  VAL   A O   1 
ATOM   457  C  CB  . VAL   A 1 60  ? 26.46255 -34.26699 -6.91765  1.000 41.08894  ? 594  VAL   A CB  1 
ATOM   458  C  CG1 . VAL   A 1 60  ? 25.43683 -34.46386 -8.02471  1.000 37.88171  ? 594  VAL   A CG1 1 
ATOM   459  C  CG2 . VAL   A 1 60  ? 25.91138 -34.73437 -5.58232  1.000 40.65367  ? 594  VAL   A CG2 1 
ATOM   460  N  N   . LEU   A 1 61  ? 29.05355 -33.36753 -8.50595  1.000 40.11635  ? 595  LEU   A N   1 
ATOM   461  C  CA  . LEU   A 1 61  ? 29.71037 -32.84730 -9.70172  1.000 34.85515  ? 595  LEU   A CA  1 
ATOM   462  C  C   . LEU   A 1 61  ? 30.80593 -33.79011 -10.18192 1.000 32.56864  ? 595  LEU   A C   1 
ATOM   463  O  O   . LEU   A 1 61  ? 30.99483 -33.97093 -11.39105 1.000 36.85768  ? 595  LEU   A O   1 
ATOM   464  C  CB  . LEU   A 1 61  ? 30.28286 -31.45762 -9.42459  1.000 36.56829  ? 595  LEU   A CB  1 
ATOM   465  C  CG  . LEU   A 1 61  ? 30.95762 -30.74774 -10.60155 1.000 39.04928  ? 595  LEU   A CG  1 
ATOM   466  C  CD1 . LEU   A 1 61  ? 30.11945 -30.82994 -11.87755 1.000 39.61256  ? 595  LEU   A CD1 1 
ATOM   467  C  CD2 . LEU   A 1 61  ? 31.25582 -29.30425 -10.23723 1.000 29.52018  ? 595  LEU   A CD2 1 
ATOM   468  N  N   . CYS   A 1 62  ? 31.53735 -34.40136 -9.24672  1.000 36.95077  ? 596  CYS   A N   1 
ATOM   469  C  CA  . CYS   A 1 62  ? 32.56165 -35.37029 -9.62204  1.000 41.15555  ? 596  CYS   A CA  1 
ATOM   470  C  C   . CYS   A 1 62  ? 31.94661 -36.57462 -10.32323 1.000 39.78238  ? 596  CYS   A C   1 
ATOM   471  O  O   . CYS   A 1 62  ? 32.48105 -37.06099 -11.32770 1.000 41.16557  ? 596  CYS   A O   1 
ATOM   472  C  CB  . CYS   A 1 62  ? 33.34047 -35.81491 -8.38378  1.000 37.35480  ? 596  CYS   A CB  1 
ATOM   473  S  SG  . CYS   A 1 62  ? 34.55878 -34.61723 -7.78828  1.000 37.64763  ? 596  CYS   A SG  1 
ATOM   474  N  N   . ARG   A 1 63  ? 30.82142 -37.07191 -9.80446  1.000 40.35835  ? 597  ARG   A N   1 
ATOM   475  C  CA  . ARG   A 1 63  ? 30.15583 -38.20881 -10.43186 1.000 38.80284  ? 597  ARG   A CA  1 
ATOM   476  C  C   . ARG   A 1 63  ? 29.54712 -37.82041 -11.77349 1.000 39.13884  ? 597  ARG   A C   1 
ATOM   477  O  O   . ARG   A 1 63  ? 29.52795 -38.62799 -12.71063 1.000 36.20352  ? 597  ARG   A O   1 
ATOM   478  C  CB  . ARG   A 1 63  ? 29.08337 -38.76735 -9.49659  1.000 39.68906  ? 597  ARG   A CB  1 
ATOM   479  C  CG  . ARG   A 1 63  ? 28.71730 -40.21979 -9.75352  1.000 44.89215  ? 597  ARG   A CG  1 
ATOM   480  C  CD  . ARG   A 1 63  ? 28.08562 -40.85563 -8.52643  1.000 48.78147  ? 597  ARG   A CD  1 
ATOM   481  N  NE  . ARG   A 1 63  ? 27.63723 -39.84962 -7.57095  1.000 54.58865  ? 597  ARG   A NE  1 
ATOM   482  C  CZ  . ARG   A 1 63  ? 27.88267 -39.88843 -6.26865  1.000 48.70908  ? 597  ARG   A CZ  1 
ATOM   483  N  NH1 . ARG   A 1 63  ? 28.57337 -40.87698 -5.72383  1.000 47.45599  ? 597  ARG   A NH1 1 
ATOM   484  N  NH2 . ARG   A 1 63  ? 27.42734 -38.90832 -5.49435  1.000 47.26869  ? 597  ARG   A NH2 1 
ATOM   485  N  N   . TRP   A 1 64  ? 29.05005 -36.58583 -11.88806 1.000 37.56793  ? 598  TRP   A N   1 
ATOM   486  C  CA  . TRP   A 1 64  ? 28.44780 -36.15444 -13.14498 1.000 34.67286  ? 598  TRP   A CA  1 
ATOM   487  C  C   . TRP   A 1 64  ? 29.49538 -36.01759 -14.24199 1.000 35.96858  ? 598  TRP   A C   1 
ATOM   488  O  O   . TRP   A 1 64  ? 29.26660 -36.44613 -15.37921 1.000 34.40503  ? 598  TRP   A O   1 
ATOM   489  C  CB  . TRP   A 1 64  ? 27.70202 -34.83460 -12.95644 1.000 34.34109  ? 598  TRP   A CB  1 
ATOM   490  C  CG  . TRP   A 1 64  ? 27.05695 -34.34401 -14.21556 1.000 36.17503  ? 598  TRP   A CG  1 
ATOM   491  C  CD1 . TRP   A 1 64  ? 25.87930 -34.77122 -14.75520 1.000 33.19019  ? 598  TRP   A CD1 1 
ATOM   492  C  CD2 . TRP   A 1 64  ? 27.56815 -33.34587 -15.10625 1.000 36.95763  ? 598  TRP   A CD2 1 
ATOM   493  N  NE1 . TRP   A 1 64  ? 25.61995 -34.09339 -15.92246 1.000 34.27521  ? 598  TRP   A NE1 1 
ATOM   494  C  CE2 . TRP   A 1 64  ? 26.64245 -33.21279 -16.16038 1.000 36.24080  ? 598  TRP   A CE2 1 
ATOM   495  C  CE3 . TRP   A 1 64  ? 28.71667 -32.54810 -15.11168 1.000 31.37250  ? 598  TRP   A CE3 1 
ATOM   496  C  CZ2 . TRP   A 1 64  ? 26.82998 -32.31445 -17.20905 1.000 29.81222  ? 598  TRP   A CZ2 1 
ATOM   497  C  CZ3 . TRP   A 1 64  ? 28.90100 -31.65801 -16.15226 1.000 32.52046  ? 598  TRP   A CZ3 1 
ATOM   498  C  CH2 . TRP   A 1 64  ? 27.96296 -31.54766 -17.18652 1.000 26.51787  ? 598  TRP   A CH2 1 
ATOM   499  N  N   . ILE   A 1 65  ? 30.64656 -35.41818 -13.92309 1.000 35.05750  ? 599  ILE   A N   1 
ATOM   500  C  CA  . ILE   A 1 65  ? 31.71329 -35.27834 -14.91164 1.000 28.97496  ? 599  ILE   A CA  1 
ATOM   501  C  C   . ILE   A 1 65  ? 32.18443 -36.64856 -15.38042 1.000 29.69357  ? 599  ILE   A C   1 
ATOM   502  O  O   . ILE   A 1 65  ? 32.40530 -36.87269 -16.57685 1.000 30.46976  ? 599  ILE   A O   1 
ATOM   503  C  CB  . ILE   A 1 65  ? 32.87181 -34.44585 -14.33111 1.000 30.29326  ? 599  ILE   A CB  1 
ATOM   504  C  CG1 . ILE   A 1 65  ? 32.43513 -32.99609 -14.12411 1.000 25.80346  ? 599  ILE   A CG1 1 
ATOM   505  C  CG2 . ILE   A 1 65  ? 34.09623 -34.51966 -15.23644 1.000 37.03567  ? 599  ILE   A CG2 1 
ATOM   506  C  CD1 . ILE   A 1 65  ? 33.48104 -32.13513 -13.45721 1.000 33.09579  ? 599  ILE   A CD1 1 
ATOM   507  N  N   . LEU   A 1 66  ? 32.32315 -37.59288 -14.44827 1.000 32.82812  ? 600  LEU   A N   1 
ATOM   508  C  CA  . LEU   A 1 66  ? 32.73933 -38.93993 -14.81582 1.000 31.97636  ? 600  LEU   A CA  1 
ATOM   509  C  C   . LEU   A 1 66  ? 31.65250 -39.67000 -15.59192 1.000 32.16487  ? 600  LEU   A C   1 
ATOM   510  O  O   . LEU   A 1 66  ? 31.96249 -40.48105 -16.47199 1.000 32.71481  ? 600  LEU   A O   1 
ATOM   511  C  CB  . LEU   A 1 66  ? 33.12403 -39.72438 -13.56665 1.000 37.00630  ? 600  LEU   A CB  1 
ATOM   512  C  CG  . LEU   A 1 66  ? 34.49144 -39.35207 -12.99717 1.000 42.82938  ? 600  LEU   A CG  1 
ATOM   513  C  CD1 . LEU   A 1 66  ? 34.74221 -40.09942 -11.70499 1.000 41.10925  ? 600  LEU   A CD1 1 
ATOM   514  C  CD2 . LEU   A 1 66  ? 35.59337 -39.62532 -14.00838 1.000 34.28333  ? 600  LEU   A CD2 1 
ATOM   515  N  N   . SER   A 1 67  ? 30.38100 -39.40049 -15.28626 1.000 35.86954  ? 601  SER   A N   1 
ATOM   516  C  CA  . SER   A 1 67  ? 29.29617 -39.98907 -16.06643 1.000 32.71042  ? 601  SER   A CA  1 
ATOM   517  C  C   . SER   A 1 67  ? 29.32243 -39.48088 -17.50348 1.000 32.05363  ? 601  SER   A C   1 
ATOM   518  O  O   . SER   A 1 67  ? 29.17088 -40.25756 -18.45494 1.000 34.18104  ? 601  SER   A O   1 
ATOM   519  C  CB  . SER   A 1 67  ? 27.94936 -39.68153 -15.41199 1.000 33.24718  ? 601  SER   A CB  1 
ATOM   520  O  OG  . SER   A 1 67  ? 27.53693 -40.72976 -14.55336 1.000 37.14411  ? 601  SER   A OG  1 
ATOM   521  N  N   . VAL   A 1 68  ? 29.52868 -38.17256 -17.67678 1.000 33.99272  ? 602  VAL   A N   1 
ATOM   522  C  CA  . VAL   A 1 68  ? 29.59473 -37.58837 -19.01497 1.000 33.29980  ? 602  VAL   A CA  1 
ATOM   523  C  C   . VAL   A 1 68  ? 30.77753 -38.15670 -19.78626 1.000 34.65008  ? 602  VAL   A C   1 
ATOM   524  O  O   . VAL   A 1 68  ? 30.64192 -38.59096 -20.93651 1.000 39.24644  ? 602  VAL   A O   1 
ATOM   525  C  CB  . VAL   A 1 68  ? 29.67597 -36.05381 -18.92830 1.000 32.45573  ? 602  VAL   A CB  1 
ATOM   526  C  CG1 . VAL   A 1 68  ? 29.96167 -35.46058 -20.30315 1.000 30.90860  ? 602  VAL   A CG1 1 
ATOM   527  C  CG2 . VAL   A 1 68  ? 28.39242 -35.48258 -18.35610 1.000 30.59324  ? 602  VAL   A CG2 1 
ATOM   528  N  N   . LYS   A 1 69  ? 31.95989 -38.14594 -19.16443 1.000 34.62752  ? 603  LYS   A N   1 
ATOM   529  C  CA  . LYS   A 1 69  ? 33.16439 -38.63762 -19.82540 1.000 33.28980  ? 603  LYS   A CA  1 
ATOM   530  C  C   . LYS   A 1 69  ? 33.02611 -40.10337 -20.21450 1.000 32.87331  ? 603  LYS   A C   1 
ATOM   531  O  O   . LYS   A 1 69  ? 33.48242 -40.51396 -21.28920 1.000 35.19538  ? 603  LYS   A O   1 
ATOM   532  C  CB  . LYS   A 1 69  ? 34.37368 -38.43601 -18.91078 1.000 34.19440  ? 603  LYS   A CB  1 
ATOM   533  C  CG  . LYS   A 1 69  ? 35.66720 -39.03991 -19.42907 1.000 29.77104  ? 603  LYS   A CG  1 
ATOM   534  C  CD  . LYS   A 1 69  ? 36.86263 -38.57928 -18.60548 1.000 30.86284  ? 603  LYS   A CD  1 
ATOM   535  C  CE  . LYS   A 1 69  ? 37.13637 -39.52996 -17.44970 1.000 28.13694  ? 603  LYS   A CE  1 
ATOM   536  N  NZ  . LYS   A 1 69  ? 37.74772 -40.80712 -17.91408 1.000 35.02638  ? 603  LYS   A NZ  1 
ATOM   537  N  N   . LYS   A 1 70  ? 32.39549 -40.90800 -19.35518 1.000 34.04010  ? 604  LYS   A N   1 
ATOM   538  C  CA  . LYS   A 1 70  ? 32.25857 -42.33079 -19.64534 1.000 31.53953  ? 604  LYS   A CA  1 
ATOM   539  C  C   . LYS   A 1 70  ? 31.31977 -42.57813 -20.82286 1.000 34.89557  ? 604  LYS   A C   1 
ATOM   540  O  O   . LYS   A 1 70  ? 31.48202 -43.56710 -21.54638 1.000 35.80499  ? 604  LYS   A O   1 
ATOM   541  C  CB  . LYS   A 1 70  ? 31.77555 -43.06400 -18.38776 1.000 36.18412  ? 604  LYS   A CB  1 
ATOM   542  C  CG  . LYS   A 1 70  ? 30.91065 -44.28948 -18.63557 1.000 40.90775  ? 604  LYS   A CG  1 
ATOM   543  C  CD  . LYS   A 1 70  ? 30.78318 -45.13192 -17.37877 1.000 40.37438  ? 604  LYS   A CD  1 
ATOM   544  C  CE  . LYS   A 1 70  ? 30.56700 -46.59765 -17.70580 1.000 51.16405  ? 604  LYS   A CE  1 
ATOM   545  N  NZ  . LYS   A 1 70  ? 30.37703 -47.41168 -16.47309 1.000 48.71711  ? 604  LYS   A NZ  1 
ATOM   546  N  N   . ASN   A 1 71  ? 30.35475 -41.68808 -21.04695 1.000 34.57258  ? 605  ASN   A N   1 
ATOM   547  C  CA  . ASN   A 1 71  ? 29.36690 -41.85627 -22.10477 1.000 33.88984  ? 605  ASN   A CA  1 
ATOM   548  C  C   . ASN   A 1 71  ? 29.84544 -41.34582 -23.46335 1.000 36.85064  ? 605  ASN   A C   1 
ATOM   549  O  O   . ASN   A 1 71  ? 29.06661 -41.34766 -24.42250 1.000 33.74979  ? 605  ASN   A O   1 
ATOM   550  C  CB  . ASN   A 1 71  ? 28.05814 -41.16945 -21.71080 1.000 37.00176  ? 605  ASN   A CB  1 
ATOM   551  C  CG  . ASN   A 1 71  ? 27.05723 -42.13338 -21.10880 1.000 41.63441  ? 605  ASN   A CG  1 
ATOM   552  O  OD1 . ASN   A 1 71  ? 26.11403 -42.55589 -21.77461 1.000 49.26320  ? 605  ASN   A OD1 1 
ATOM   553  N  ND2 . ASN   A 1 71  ? 27.25791 -42.48815 -19.84329 1.000 34.68627  ? 605  ASN   A ND2 1 
ATOM   554  N  N   . TYR   A 1 72  ? 31.09363 -40.90291 -23.56399 1.000 34.55914  ? 606  TYR   A N   1 
ATOM   555  C  CA  . TYR   A 1 72  ? 31.74805 -40.67892 -24.84378 1.000 28.50404  ? 606  TYR   A CA  1 
ATOM   556  C  C   . TYR   A 1 72  ? 32.55381 -41.91961 -25.20728 1.000 32.33653  ? 606  TYR   A C   1 
ATOM   557  O  O   . TYR   A 1 72  ? 33.04844 -42.63338 -24.33093 1.000 37.30305  ? 606  TYR   A O   1 
ATOM   558  C  CB  . TYR   A 1 72  ? 32.65805 -39.44949 -24.79499 1.000 27.88599  ? 606  TYR   A CB  1 
ATOM   559  C  CG  . TYR   A 1 72  ? 31.91344 -38.13887 -24.90949 1.000 30.81882  ? 606  TYR   A CG  1 
ATOM   560  C  CD1 . TYR   A 1 72  ? 31.61648 -37.59307 -26.15146 1.000 27.16164  ? 606  TYR   A CD1 1 
ATOM   561  C  CD2 . TYR   A 1 72  ? 31.50428 -37.44853 -23.77662 1.000 28.97049  ? 606  TYR   A CD2 1 
ATOM   562  C  CE1 . TYR   A 1 72  ? 30.93533 -36.39448 -26.25891 1.000 29.39296  ? 606  TYR   A CE1 1 
ATOM   563  C  CE2 . TYR   A 1 72  ? 30.82075 -36.25188 -23.87534 1.000 33.13524  ? 606  TYR   A CE2 1 
ATOM   564  C  CZ  . TYR   A 1 72  ? 30.53454 -35.73131 -25.11859 1.000 33.42293  ? 606  TYR   A CZ  1 
ATOM   565  O  OH  . TYR   A 1 72  ? 29.85360 -34.53847 -25.22032 1.000 35.00184  ? 606  TYR   A OH  1 
ATOM   566  N  N   . ARG   A 1 73  ? 32.68074 -42.17642 -26.50601 1.000 36.14069  ? 607  ARG   A N   1 
ATOM   567  C  CA  . ARG   A 1 73  ? 33.31097 -43.39518 -26.99600 1.000 39.51946  ? 607  ARG   A CA  1 
ATOM   568  C  C   . ARG   A 1 73  ? 34.77843 -43.13250 -27.31126 1.000 39.52213  ? 607  ARG   A C   1 
ATOM   569  O  O   . ARG   A 1 73  ? 35.09870 -42.33458 -28.20003 1.000 40.97318  ? 607  ARG   A O   1 
ATOM   570  C  CB  . ARG   A 1 73  ? 32.56945 -43.93519 -28.21835 1.000 42.59894  ? 607  ARG   A CB  1 
ATOM   571  C  CG  . ARG   A 1 73  ? 31.27387 -44.63325 -27.83741 1.000 39.19052  ? 607  ARG   A CG  1 
ATOM   572  C  CD  . ARG   A 1 73  ? 30.23807 -44.61668 -28.94693 1.000 47.09304  ? 607  ARG   A CD  1 
ATOM   573  N  NE  . ARG   A 1 73  ? 28.97238 -45.21115 -28.52847 1.000 50.55730  ? 607  ARG   A NE  1 
ATOM   574  C  CZ  . ARG   A 1 73  ? 28.81671 -46.46634 -28.12654 1.000 57.15397  ? 607  ARG   A CZ  1 
ATOM   575  N  NH1 . ARG   A 1 73  ? 29.80924 -47.34184 -28.18077 1.000 56.50154  ? 607  ARG   A NH1 1 
ATOM   576  N  NH2 . ARG   A 1 73  ? 27.62966 -46.85829 -27.67166 1.000 55.40624  ? 607  ARG   A NH2 1 
ATOM   577  N  N   . LYS   A 1 74  ? 35.66247 -43.81146 -26.57458 1.000 38.78430  ? 608  LYS   A N   1 
ATOM   578  C  CA  . LYS   A 1 74  ? 37.09824 -43.63695 -26.76270 1.000 46.17304  ? 608  LYS   A CA  1 
ATOM   579  C  C   . LYS   A 1 74  ? 37.55114 -44.12459 -28.13139 1.000 45.64814  ? 608  LYS   A C   1 
ATOM   580  O  O   . LYS   A 1 74  ? 38.49074 -43.56635 -28.70869 1.000 52.32981  ? 608  LYS   A O   1 
ATOM   581  C  CB  . LYS   A 1 74  ? 37.85634 -44.37224 -25.65868 1.000 53.62194  ? 608  LYS   A CB  1 
ATOM   582  C  CG  . LYS   A 1 74  ? 39.36180 -44.19288 -25.70553 1.000 51.84560  ? 608  LYS   A CG  1 
ATOM   583  C  CD  . LYS   A 1 74  ? 39.79843 -42.94577 -24.95378 1.000 55.82333  ? 608  LYS   A CD  1 
ATOM   584  C  CE  . LYS   A 1 74  ? 41.28543 -42.99043 -24.64124 1.000 54.10162  ? 608  LYS   A CE  1 
ATOM   585  N  NZ  . LYS   A 1 74  ? 41.54966 -43.00819 -23.17731 1.000 55.65544  ? 608  LYS   A NZ  1 
ATOM   586  N  N   . ASN   A 1 75  ? 36.89859 -45.15586 -28.67044 1.000 42.35563  ? 609  ASN   A N   1 
ATOM   587  C  CA  . ASN   A 1 75  ? 37.29680 -45.69168 -29.96683 1.000 50.15587  ? 609  ASN   A CA  1 
ATOM   588  C  C   . ASN   A 1 75  ? 36.93723 -44.76991 -31.12493 1.000 48.49781  ? 609  ASN   A C   1 
ATOM   589  O  O   . ASN   A 1 75  ? 37.30262 -45.06774 -32.26735 1.000 51.37705  ? 609  ASN   A O   1 
ATOM   590  C  CB  . ASN   A 1 75  ? 36.66829 -47.07056 -30.17831 1.000 55.22045  ? 609  ASN   A CB  1 
ATOM   591  C  CG  . ASN   A 1 75  ? 35.18053 -47.08704 -29.87889 1.000 57.30255  ? 609  ASN   A CG  1 
ATOM   592  O  OD1 . ASN   A 1 75  ? 34.76629 -47.13961 -28.71996 1.000 56.26915  ? 609  ASN   A OD1 1 
ATOM   593  N  ND2 . ASN   A 1 75  ? 34.36825 -47.04799 -30.92679 1.000 52.91334  ? 609  ASN   A ND2 1 
ATOM   594  N  N   . VAL   A 1 76  ? 36.23069 -43.67747 -30.86498 1.000 43.41637  ? 610  VAL   A N   1 
ATOM   595  C  CA  . VAL   A 1 76  ? 35.94218 -42.67508 -31.88126 1.000 34.77786  ? 610  VAL   A CA  1 
ATOM   596  C  C   . VAL   A 1 76  ? 37.07362 -41.65731 -31.87094 1.000 40.17104  ? 610  VAL   A C   1 
ATOM   597  O  O   . VAL   A 1 76  ? 37.39771 -41.08771 -30.82190 1.000 38.37271  ? 610  VAL   A O   1 
ATOM   598  C  CB  . VAL   A 1 76  ? 34.58223 -42.00678 -31.62344 1.000 38.45892  ? 610  VAL   A CB  1 
ATOM   599  C  CG1 . VAL   A 1 76  ? 34.34865 -40.87374 -32.60416 1.000 38.10605  ? 610  VAL   A CG1 1 
ATOM   600  C  CG2 . VAL   A 1 76  ? 33.46690 -43.03425 -31.71364 1.000 33.17401  ? 610  VAL   A CG2 1 
ATOM   601  N  N   . ALA   A 1 77  ? 37.67264 -41.42592 -33.04272 1.000 42.69297  ? 611  ALA   A N   1 
ATOM   602  C  CA  . ALA   A 1 77  ? 38.93717 -40.69688 -33.11012 1.000 36.84105  ? 611  ALA   A CA  1 
ATOM   603  C  C   . ALA   A 1 77  ? 38.78720 -39.24457 -32.66965 1.000 37.30623  ? 611  ALA   A C   1 
ATOM   604  O  O   . ALA   A 1 77  ? 39.59614 -38.74566 -31.87720 1.000 34.33820  ? 611  ALA   A O   1 
ATOM   605  C  CB  . ALA   A 1 77  ? 39.50287 -40.76865 -34.52771 1.000 41.80117  ? 611  ALA   A CB  1 
ATOM   606  N  N   . TYR   A 1 78  ? 37.77207 -38.54579 -33.17794 1.000 33.76115  ? 612  TYR   A N   1 
ATOM   607  C  CA  . TYR   A 1 78  ? 37.58227 -37.12903 -32.89146 1.000 35.03761  ? 612  TYR   A CA  1 
ATOM   608  C  C   . TYR   A 1 78  ? 36.43347 -36.88525 -31.92078 1.000 37.46511  ? 612  TYR   A C   1 
ATOM   609  O  O   . TYR   A 1 78  ? 36.64888 -36.36717 -30.82257 1.000 39.78049  ? 612  TYR   A O   1 
ATOM   610  C  CB  . TYR   A 1 78  ? 37.35280 -36.35645 -34.19500 1.000 33.78826  ? 612  TYR   A CB  1 
ATOM   611  C  CG  . TYR   A 1 78  ? 37.17305 -34.87066 -33.99902 1.000 30.19379  ? 612  TYR   A CG  1 
ATOM   612  C  CD1 . TYR   A 1 78  ? 38.22825 -34.07378 -33.58089 1.000 29.80103  ? 612  TYR   A CD1 1 
ATOM   613  C  CD2 . TYR   A 1 78  ? 35.94422 -34.26514 -34.22812 1.000 33.57367  ? 612  TYR   A CD2 1 
ATOM   614  C  CE1 . TYR   A 1 78  ? 38.06991 -32.71296 -33.39775 1.000 28.89992  ? 612  TYR   A CE1 1 
ATOM   615  C  CE2 . TYR   A 1 78  ? 35.77478 -32.90353 -34.04755 1.000 36.74005  ? 612  TYR   A CE2 1 
ATOM   616  C  CZ  . TYR   A 1 78  ? 36.84109 -32.13209 -33.63240 1.000 33.44324  ? 612  TYR   A CZ  1 
ATOM   617  O  OH  . TYR   A 1 78  ? 36.68202 -30.77646 -33.45026 1.000 40.72891  ? 612  TYR   A OH  1 
ATOM   618  N  N   . HIS   A 1 79  ? 35.20818 -37.24232 -32.29650 1.000 37.68235  ? 613  HIS   A N   1 
ATOM   619  C  CA  . HIS   A 1 79  ? 34.04896 -36.97379 -31.45717 1.000 35.72810  ? 613  HIS   A CA  1 
ATOM   620  C  C   . HIS   A 1 79  ? 34.05217 -37.85676 -30.21590 1.000 39.24343  ? 613  HIS   A C   1 
ATOM   621  O  O   . HIS   A 1 79  ? 33.27201 -38.80841 -30.11117 1.000 42.04682  ? 613  HIS   A O   1 
ATOM   622  C  CB  . HIS   A 1 79  ? 32.76127 -37.16482 -32.25898 1.000 33.22198  ? 613  HIS   A CB  1 
ATOM   623  C  CG  . HIS   A 1 79  ? 32.58614 -36.15780 -33.34977 1.000 31.12525  ? 613  HIS   A CG  1 
ATOM   624  N  ND1 . HIS   A 1 79  ? 32.76864 -36.46640 -34.68041 1.000 29.48994  ? 613  HIS   A ND1 1 
ATOM   625  C  CD2 . HIS   A 1 79  ? 32.26815 -34.84184 -33.30545 1.000 32.46463  ? 613  HIS   A CD2 1 
ATOM   626  C  CE1 . HIS   A 1 79  ? 32.55633 -35.38561 -35.40960 1.000 32.60697  ? 613  HIS   A CE1 1 
ATOM   627  N  NE2 . HIS   A 1 79  ? 32.25105 -34.38670 -34.60019 1.000 32.68156  ? 613  HIS   A NE2 1 
ATOM   628  N  N   . ASN   A 1 80  ? 34.93590 -37.53913 -29.27115 1.000 38.58928  ? 614  ASN   A N   1 
ATOM   629  C  CA  . ASN   A 1 80  ? 35.05435 -38.26366 -28.01338 1.000 31.64258  ? 614  ASN   A CA  1 
ATOM   630  C  C   . ASN   A 1 80  ? 35.03742 -37.28660 -26.84073 1.000 28.69435  ? 614  ASN   A C   1 
ATOM   631  O  O   . ASN   A 1 80  ? 34.71138 -36.10627 -27.01259 1.000 31.78306  ? 614  ASN   A O   1 
ATOM   632  C  CB  . ASN   A 1 80  ? 36.32700 -39.11029 -28.01660 1.000 33.92594  ? 614  ASN   A CB  1 
ATOM   633  C  CG  . ASN   A 1 80  ? 37.53536 -38.34153 -28.51003 1.000 32.93474  ? 614  ASN   A CG  1 
ATOM   634  O  OD1 . ASN   A 1 80  ? 37.82436 -37.24520 -28.03759 1.000 30.61942  ? 614  ASN   A OD1 1 
ATOM   635  N  ND2 . ASN   A 1 80  ? 38.25592 -38.92166 -29.46517 1.000 35.13603  ? 614  ASN   A ND2 1 
ATOM   636  N  N   . TRP   A 1 81  ? 35.38535 -37.76723 -25.64557 1.000 28.25038  ? 615  TRP   A N   1 
ATOM   637  C  CA  . TRP   A 1 81  ? 35.36386 -36.90356 -24.46982 1.000 26.98203  ? 615  TRP   A CA  1 
ATOM   638  C  C   . TRP   A 1 81  ? 36.32813 -35.73443 -24.62174 1.000 34.85366  ? 615  TRP   A C   1 
ATOM   639  O  O   . TRP   A 1 81  ? 36.04693 -34.62520 -24.15292 1.000 37.21077  ? 615  TRP   A O   1 
ATOM   640  C  CB  . TRP   A 1 81  ? 35.70203 -37.70712 -23.21494 1.000 28.31856  ? 615  TRP   A CB  1 
ATOM   641  C  CG  . TRP   A 1 81  ? 36.24695 -36.85801 -22.10875 1.000 31.92770  ? 615  TRP   A CG  1 
ATOM   642  C  CD1 . TRP   A 1 81  ? 37.52494 -36.85696 -21.62949 1.000 29.21452  ? 615  TRP   A CD1 1 
ATOM   643  C  CD2 . TRP   A 1 81  ? 35.53053 -35.88282 -21.34222 1.000 30.45673  ? 615  TRP   A CD2 1 
ATOM   644  N  NE1 . TRP   A 1 81  ? 37.64829 -35.94242 -20.61246 1.000 32.84247  ? 615  TRP   A NE1 1 
ATOM   645  C  CE2 . TRP   A 1 81  ? 36.43803 -35.33068 -20.41663 1.000 33.33135  ? 615  TRP   A CE2 1 
ATOM   646  C  CE3 . TRP   A 1 81  ? 34.21051 -35.42271 -21.34928 1.000 32.22201  ? 615  TRP   A CE3 1 
ATOM   647  C  CZ2 . TRP   A 1 81  ? 36.06765 -34.34304 -19.50689 1.000 33.68058  ? 615  TRP   A CZ2 1 
ATOM   648  C  CZ3 . TRP   A 1 81  ? 33.84444 -34.44178 -20.44549 1.000 30.41235  ? 615  TRP   A CZ3 1 
ATOM   649  C  CH2 . TRP   A 1 81  ? 34.76982 -33.91328 -19.53699 1.000 35.35671  ? 615  TRP   A CH2 1 
ATOM   650  N  N   . ARG   A 1 82  ? 37.47175 -35.96275 -25.27335 1.000 33.47965  ? 616  ARG   A N   1 
ATOM   651  C  CA  . ARG   A 1 82  ? 38.46497 -34.90292 -25.41867 1.000 32.94362  ? 616  ARG   A CA  1 
ATOM   652  C  C   . ARG   A 1 82  ? 37.92245 -33.74343 -26.24619 1.000 32.93257  ? 616  ARG   A C   1 
ATOM   653  O  O   . ARG   A 1 82  ? 38.24277 -32.57856 -25.98103 1.000 34.36297  ? 616  ARG   A O   1 
ATOM   654  C  CB  . ARG   A 1 82  ? 39.74069 -35.46492 -26.04663 1.000 34.99141  ? 616  ARG   A CB  1 
ATOM   655  C  CG  . ARG   A 1 82  ? 40.60676 -36.27913 -25.09042 1.000 25.23949  ? 616  ARG   A CG  1 
ATOM   656  C  CD  . ARG   A 1 82  ? 40.49931 -35.77655 -23.65812 1.000 34.67640  ? 616  ARG   A CD  1 
ATOM   657  N  NE  . ARG   A 1 82  ? 41.26781 -36.59860 -22.73022 1.000 38.73275  ? 616  ARG   A NE  1 
ATOM   658  C  CZ  . ARG   A 1 82  ? 42.50191 -36.32259 -22.33147 1.000 34.48763  ? 616  ARG   A CZ  1 
ATOM   659  N  NH1 . ARG   A 1 82  ? 43.14078 -35.24487 -22.75726 1.000 34.86224  ? 616  ARG   A NH1 1 
ATOM   660  N  NH2 . ARG   A 1 82  ? 43.11054 -37.14913 -21.48566 1.000 33.55073  ? 616  ARG   A NH2 1 
ATOM   661  N  N   . HIS   A 1 83  ? 37.09732 -34.03964 -27.25308 1.000 32.62170  ? 617  HIS   A N   1 
ATOM   662  C  CA  . HIS   A 1 83  ? 36.49557 -32.96913 -28.04073 1.000 31.42343  ? 617  HIS   A CA  1 
ATOM   663  C  C   . HIS   A 1 83  ? 35.46044 -32.20065 -27.22612 1.000 28.86898  ? 617  HIS   A C   1 
ATOM   664  O  O   . HIS   A 1 83  ? 35.37434 -30.97103 -27.32355 1.000 28.21548  ? 617  HIS   A O   1 
ATOM   665  C  CB  . HIS   A 1 83  ? 35.87012 -33.53774 -29.31357 1.000 27.82134  ? 617  HIS   A CB  1 
ATOM   666  C  CG  . HIS   A 1 83  ? 34.89985 -32.60799 -29.97083 1.000 29.25755  ? 617  HIS   A CG  1 
ATOM   667  N  ND1 . HIS   A 1 83  ? 35.23308 -31.32083 -30.33474 1.000 31.41151  ? 617  HIS   A ND1 1 
ATOM   668  C  CD2 . HIS   A 1 83  ? 33.60167 -32.77314 -30.31754 1.000 31.00734  ? 617  HIS   A CD2 1 
ATOM   669  C  CE1 . HIS   A 1 83  ? 34.18367 -30.73503 -30.88277 1.000 29.20049  ? 617  HIS   A CE1 1 
ATOM   670  N  NE2 . HIS   A 1 83  ? 33.18115 -31.59489 -30.88467 1.000 34.83523  ? 617  HIS   A NE2 1 
ATOM   671  N  N   . ALA   A 1 84  ? 34.66860 -32.90608 -26.41431 1.000 30.85633  ? 618  ALA   A N   1 
ATOM   672  C  CA  . ALA   A 1 84  ? 33.69700 -32.23068 -25.55984 1.000 31.68118  ? 618  ALA   A CA  1 
ATOM   673  C  C   . ALA   A 1 84  ? 34.38967 -31.39752 -24.49189 1.000 29.78026  ? 618  ALA   A C   1 
ATOM   674  O  O   . ALA   A 1 84  ? 33.94026 -30.29102 -24.16945 1.000 31.05920  ? 618  ALA   A O   1 
ATOM   675  C  CB  . ALA   A 1 84  ? 32.76393 -33.25159 -24.91471 1.000 32.77846  ? 618  ALA   A CB  1 
ATOM   676  N  N   . PHE   A 1 85  ? 35.47896 -31.92141 -23.92609 1.000 31.48503  ? 619  PHE   A N   1 
ATOM   677  C  CA  . PHE   A 1 85  ? 36.25299 -31.16459 -22.94887 1.000 32.46914  ? 619  PHE   A CA  1 
ATOM   678  C  C   . PHE   A 1 85  ? 36.79937 -29.87848 -23.55568 1.000 29.23252  ? 619  PHE   A C   1 
ATOM   679  O  O   . PHE   A 1 85  ? 36.78614 -28.82327 -22.91119 1.000 30.37942  ? 619  PHE   A O   1 
ATOM   680  C  CB  . PHE   A 1 85  ? 37.39020 -32.03365 -22.41191 1.000 34.13926  ? 619  PHE   A CB  1 
ATOM   681  C  CG  . PHE   A 1 85  ? 38.36279 -31.29475 -21.54437 1.000 31.92994  ? 619  PHE   A CG  1 
ATOM   682  C  CD1 . PHE   A 1 85  ? 37.98048 -30.81273 -20.30652 1.000 34.26397  ? 619  PHE   A CD1 1 
ATOM   683  C  CD2 . PHE   A 1 85  ? 39.66449 -31.08605 -21.96825 1.000 34.72688  ? 619  PHE   A CD2 1 
ATOM   684  C  CE1 . PHE   A 1 85  ? 38.87651 -30.13239 -19.50897 1.000 32.34329  ? 619  PHE   A CE1 1 
ATOM   685  C  CE2 . PHE   A 1 85  ? 40.56557 -30.40725 -21.17445 1.000 31.48043  ? 619  PHE   A CE2 1 
ATOM   686  C  CZ  . PHE   A 1 85  ? 40.17122 -29.92989 -19.94434 1.000 30.76924  ? 619  PHE   A CZ  1 
ATOM   687  N  N   . ASN   A 1 86  ? 37.27386 -29.94685 -24.80251 1.000 32.83062  ? 620  ASN   A N   1 
ATOM   688  C  CA  . ASN   A 1 86  ? 37.82741 -28.76774 -25.46133 1.000 31.52348  ? 620  ASN   A CA  1 
ATOM   689  C  C   . ASN   A 1 86  ? 36.73719 -27.75084 -25.78839 1.000 29.56130  ? 620  ASN   A C   1 
ATOM   690  O  O   . ASN   A 1 86  ? 36.94109 -26.54176 -25.62307 1.000 32.92495  ? 620  ASN   A O   1 
ATOM   691  C  CB  . ASN   A 1 86  ? 38.57790 -29.18565 -26.72879 1.000 29.46387  ? 620  ASN   A CB  1 
ATOM   692  C  CG  . ASN   A 1 86  ? 40.02133 -29.59139 -26.45594 1.000 30.68500  ? 620  ASN   A CG  1 
ATOM   693  O  OD1 . ASN   A 1 86  ? 40.84412 -28.77128 -26.04977 1.000 32.33920  ? 620  ASN   A OD1 1 
ATOM   694  N  ND2 . ASN   A 1 86  ? 40.33330 -30.86273 -26.68689 1.000 30.21270  ? 620  ASN   A ND2 1 
ATOM   695  N  N   . THR   A 1 87  ? 35.57448 -28.21985 -26.25737 1.000 30.54500  ? 621  THR   A N   1 
ATOM   696  C  CA  . THR   A 1 87  ? 34.45969 -27.31217 -26.52320 1.000 30.66825  ? 621  THR   A CA  1 
ATOM   697  C  C   . THR   A 1 87  ? 34.04371 -26.56991 -25.25834 1.000 29.17808  ? 621  THR   A C   1 
ATOM   698  O  O   . THR   A 1 87  ? 33.68921 -25.38565 -25.30938 1.000 31.87885  ? 621  THR   A O   1 
ATOM   699  C  CB  . THR   A 1 87  ? 33.27443 -28.08605 -27.10753 1.000 33.08427  ? 621  THR   A CB  1 
ATOM   700  O  OG1 . THR   A 1 87  ? 33.72044 -28.89479 -28.20280 1.000 32.12209  ? 621  THR   A OG1 1 
ATOM   701  C  CG2 . THR   A 1 87  ? 32.19261 -27.12927 -27.59886 1.000 30.52578  ? 621  THR   A CG2 1 
ATOM   702  N  N   . ALA   A 1 88  ? 34.08777 -27.25111 -24.11104 1.000 30.03371  ? 622  ALA   A N   1 
ATOM   703  C  CA  . ALA   A 1 88  ? 33.80735 -26.58948 -22.84176 1.000 28.91878  ? 622  ALA   A CA  1 
ATOM   704  C  C   . ALA   A 1 88  ? 34.92774 -25.63064 -22.45979 1.000 34.96699  ? 622  ALA   A C   1 
ATOM   705  O  O   . ALA   A 1 88  ? 34.67136 -24.56316 -21.88981 1.000 35.69879  ? 622  ALA   A O   1 
ATOM   706  C  CB  . ALA   A 1 88  ? 33.59618 -27.62928 -21.74315 1.000 26.75178  ? 622  ALA   A CB  1 
ATOM   707  N  N   . GLN   A 1 89  ? 36.17688 -25.99414 -22.76031 1.000 30.56327  ? 623  GLN   A N   1 
ATOM   708  C  CA  . GLN   A 1 89  ? 37.29801 -25.11879 -22.43422 1.000 32.42435  ? 623  GLN   A CA  1 
ATOM   709  C  C   . GLN   A 1 89  ? 37.21214 -23.81363 -23.21375 1.000 36.30254  ? 623  GLN   A C   1 
ATOM   710  O  O   . GLN   A 1 89  ? 37.39999 -22.72785 -22.65279 1.000 35.20251  ? 623  GLN   A O   1 
ATOM   711  C  CB  . GLN   A 1 89  ? 38.62203 -25.83164 -22.71442 1.000 33.20220  ? 623  GLN   A CB  1 
ATOM   712  C  CG  . GLN   A 1 89  ? 39.85598 -25.07407 -22.23993 1.000 31.15133  ? 623  GLN   A CG  1 
ATOM   713  C  CD  . GLN   A 1 89  ? 40.31945 -24.01484 -23.22870 1.000 32.10630  ? 623  GLN   A CD  1 
ATOM   714  O  OE1 . GLN   A 1 89  ? 40.41198 -24.26665 -24.43055 1.000 34.40234  ? 623  GLN   A OE1 1 
ATOM   715  N  NE2 . GLN   A 1 89  ? 40.61003 -22.82188 -22.72384 1.000 34.33108  ? 623  GLN   A NE2 1 
ATOM   716  N  N   . CYS   A 1 90  ? 36.93612 -23.90135 -24.51739 1.000 33.83319  ? 624  CYS   A N   1 
ATOM   717  C  CA  . CYS   A 1 90  ? 36.78333 -22.69060 -25.31605 1.000 32.03736  ? 624  CYS   A CA  1 
ATOM   718  C  C   . CYS   A 1 90  ? 35.60509 -21.86031 -24.82991 1.000 33.24443  ? 624  CYS   A C   1 
ATOM   719  O  O   . CYS   A 1 90  ? 35.64956 -20.62515 -24.86685 1.000 34.77662  ? 624  CYS   A O   1 
ATOM   720  C  CB  . CYS   A 1 90  ? 36.61223 -23.04486 -26.79053 1.000 33.04534  ? 624  CYS   A CB  1 
ATOM   721  S  SG  . CYS   A 1 90  ? 36.61022 -21.59912 -27.87043 1.000 39.29109  ? 624  CYS   A SG  1 
ATOM   722  N  N   . MET   A 1 91  ? 34.53599 -22.52304 -24.38085 1.000 35.92629  ? 625  MET   A N   1 
ATOM   723  C  CA  . MET   A 1 91  ? 33.43221 -21.80423 -23.75525 1.000 37.84758  ? 625  MET   A CA  1 
ATOM   724  C  C   . MET   A 1 91  ? 33.90664 -21.05907 -22.51627 1.000 34.87704  ? 625  MET   A C   1 
ATOM   725  O  O   . MET   A 1 91  ? 33.53718 -19.90012 -22.29927 1.000 38.62401  ? 625  MET   A O   1 
ATOM   726  C  CB  . MET   A 1 91  ? 32.30545 -22.77594 -23.40427 1.000 38.01948  ? 625  MET   A CB  1 
ATOM   727  C  CG  . MET   A 1 91  ? 31.10955 -22.12730 -22.73220 1.000 30.86372  ? 625  MET   A CG  1 
ATOM   728  S  SD  . MET   A 1 91  ? 30.18584 -21.07257 -23.86279 1.000 38.43407  ? 625  MET   A SD  1 
ATOM   729  C  CE  . MET   A 1 91  ? 29.63929 -22.27482 -25.07141 1.000 32.02838  ? 625  MET   A CE  1 
ATOM   730  N  N   . PHE   A 1 92  ? 34.73996 -21.70536 -21.69867 1.000 35.50931  ? 626  PHE   A N   1 
ATOM   731  C  CA  . PHE   A 1 92  ? 35.31230 -21.03285 -20.53678 1.000 35.18795  ? 626  PHE   A CA  1 
ATOM   732  C  C   . PHE   A 1 92  ? 36.22065 -19.88551 -20.96302 1.000 39.69854  ? 626  PHE   A C   1 
ATOM   733  O  O   . PHE   A 1 92  ? 36.16523 -18.78883 -20.39481 1.000 39.71393  ? 626  PHE   A O   1 
ATOM   734  C  CB  . PHE   A 1 92  ? 36.07793 -22.03938 -19.67523 1.000 38.12376  ? 626  PHE   A CB  1 
ATOM   735  C  CG  . PHE   A 1 92  ? 36.56365 -21.47646 -18.36759 1.000 37.13741  ? 626  PHE   A CG  1 
ATOM   736  C  CD1 . PHE   A 1 92  ? 35.75875 -21.51704 -17.24166 1.000 32.72168  ? 626  PHE   A CD1 1 
ATOM   737  C  CD2 . PHE   A 1 92  ? 37.82888 -20.91916 -18.26057 1.000 35.14052  ? 626  PHE   A CD2 1 
ATOM   738  C  CE1 . PHE   A 1 92  ? 36.20098 -21.00485 -16.03609 1.000 38.41433  ? 626  PHE   A CE1 1 
ATOM   739  C  CE2 . PHE   A 1 92  ? 38.27676 -20.40468 -17.05612 1.000 36.21974  ? 626  PHE   A CE2 1 
ATOM   740  C  CZ  . PHE   A 1 92  ? 37.46215 -20.44823 -15.94332 1.000 34.56484  ? 626  PHE   A CZ  1 
ATOM   741  N  N   . ALA   A 1 93  ? 37.06887 -20.12314 -21.96737 1.000 38.12253  ? 627  ALA   A N   1 
ATOM   742  C  CA  . ALA   A 1 93  ? 37.96677 -19.07556 -22.44277 1.000 35.93006  ? 627  ALA   A CA  1 
ATOM   743  C  C   . ALA   A 1 93  ? 37.19492 -17.91109 -23.04878 1.000 39.22974  ? 627  ALA   A C   1 
ATOM   744  O  O   . ALA   A 1 93  ? 37.62609 -16.75595 -22.94640 1.000 36.83890  ? 627  ALA   A O   1 
ATOM   745  C  CB  . ALA   A 1 93  ? 38.95171 -19.65146 -23.45935 1.000 33.94822  ? 627  ALA   A CB  1 
ATOM   746  N  N   . ALA   A 1 94  ? 36.05225 -18.19340 -23.67696 1.000 37.20160  ? 628  ALA   A N   1 
ATOM   747  C  CA  . ALA   A 1 94  ? 35.24151 -17.13026 -24.25941 1.000 36.08115  ? 628  ALA   A CA  1 
ATOM   748  C  C   . ALA   A 1 94  ? 34.56329 -16.29722 -23.17997 1.000 38.60668  ? 628  ALA   A C   1 
ATOM   749  O  O   . ALA   A 1 94  ? 34.51840 -15.06603 -23.27492 1.000 41.07312  ? 628  ALA   A O   1 
ATOM   750  C  CB  . ALA   A 1 94  ? 34.20387 -17.72737 -25.20886 1.000 37.23313  ? 628  ALA   A CB  1 
ATOM   751  N  N   . LEU   A 1 95  ? 34.02656 -16.95020 -22.14732 1.000 39.76759  ? 629  LEU   A N   1 
ATOM   752  C  CA  . LEU   A 1 95  ? 33.38199 -16.21289 -21.06602 1.000 40.52504  ? 629  LEU   A CA  1 
ATOM   753  C  C   . LEU   A 1 95  ? 34.39718 -15.40859 -20.26406 1.000 40.62126  ? 629  LEU   A C   1 
ATOM   754  O  O   . LEU   A 1 95  ? 34.09254 -14.30580 -19.79653 1.000 43.51200  ? 629  LEU   A O   1 
ATOM   755  C  CB  . LEU   A 1 95  ? 32.61585 -17.17313 -20.15437 1.000 37.84227  ? 629  LEU   A CB  1 
ATOM   756  C  CG  . LEU   A 1 95  ? 31.51415 -18.00976 -20.81240 1.000 37.14144  ? 629  LEU   A CG  1 
ATOM   757  C  CD1 . LEU   A 1 95  ? 30.81606 -18.91356 -19.80432 1.000 42.38083  ? 629  LEU   A CD1 1 
ATOM   758  C  CD2 . LEU   A 1 95  ? 30.50835 -17.12024 -21.52247 1.000 40.70913  ? 629  LEU   A CD2 1 
ATOM   759  N  N   . LYS   A 1 96  ? 35.60899 -15.93661 -20.09944 1.000 43.79122  ? 630  LYS   A N   1 
ATOM   760  C  CA  . LYS   A 1 96  ? 36.62218 -15.26295 -19.29621 1.000 43.06632  ? 630  LYS   A CA  1 
ATOM   761  C  C   . LYS   A 1 96  ? 37.47704 -14.32931 -20.14296 1.000 38.09241  ? 630  LYS   A C   1 
ATOM   762  O  O   . LYS   A 1 96  ? 37.28693 -13.10896 -20.11486 1.000 36.94490  ? 630  LYS   A O   1 
ATOM   763  C  CB  . LYS   A 1 96  ? 37.51060 -16.28638 -18.58559 1.000 36.31756  ? 630  LYS   A CB  1 
ATOM   764  C  CG  . LYS   A 1 96  ? 36.79359 -17.10330 -17.52425 1.000 34.23062  ? 630  LYS   A CG  1 
ATOM   765  C  CD  . LYS   A 1 96  ? 36.09459 -16.20769 -16.51432 1.000 38.76563  ? 630  LYS   A CD  1 
ATOM   766  C  CE  . LYS   A 1 96  ? 35.89322 -16.92429 -15.18882 1.000 40.01865  ? 630  LYS   A CE  1 
ATOM   767  N  NZ  . LYS   A 1 96  ? 35.26713 -16.03629 -14.17102 1.000 45.22089  ? 630  LYS   A NZ  1 
ATOM   768  N  N   . ALA   A 1 97  ? 38.42557 -14.89792 -20.89266 1.000 40.33193  ? 631  ALA   A N   1 
ATOM   769  C  CA  . ALA   A 1 97  ? 39.33763 -14.08061 -21.68751 1.000 42.78396  ? 631  ALA   A CA  1 
ATOM   770  C  C   . ALA   A 1 97  ? 38.58451 -13.24958 -22.71960 1.000 42.38224  ? 631  ALA   A C   1 
ATOM   771  O  O   . ALA   A 1 97  ? 38.93208 -12.08829 -22.96633 1.000 43.11241  ? 631  ALA   A O   1 
ATOM   772  C  CB  . ALA   A 1 97  ? 40.38008 -14.96964 -22.36518 1.000 41.96776  ? 631  ALA   A CB  1 
ATOM   773  N  N   . GLY   A 1 98  ? 37.54781 -13.82218 -23.32783 1.000 43.09259  ? 632  GLY   A N   1 
ATOM   774  C  CA  . GLY   A 1 98  ? 36.72014 -13.09509 -24.26784 1.000 43.42858  ? 632  GLY   A CA  1 
ATOM   775  C  C   . GLY   A 1 98  ? 35.69558 -12.17114 -23.65005 1.000 43.87939  ? 632  GLY   A C   1 
ATOM   776  O  O   . GLY   A 1 98  ? 34.96723 -11.49430 -24.38138 1.000 43.34075  ? 632  GLY   A O   1 
ATOM   777  N  N   . LYS   A 1 99  ? 35.60821 -12.13801 -22.31728 1.000 41.13019  ? 633  LYS   A N   1 
ATOM   778  C  CA  . LYS   A 1 99  ? 34.75795 -11.21273 -21.56556 1.000 44.65197  ? 633  LYS   A CA  1 
ATOM   779  C  C   . LYS   A 1 99  ? 33.27514 -11.36224 -21.90112 1.000 51.61445  ? 633  LYS   A C   1 
ATOM   780  O  O   . LYS   A 1 99  ? 32.49666 -10.42172 -21.71108 1.000 54.17027  ? 633  LYS   A O   1 
ATOM   781  C  CB  . LYS   A 1 99  ? 35.20175 -9.76082  -21.77822 1.000 46.38667  ? 633  LYS   A CB  1 
ATOM   782  C  CG  . LYS   A 1 99  ? 36.70230 -9.54988  -21.65955 1.000 47.19414  ? 633  LYS   A CG  1 
ATOM   783  C  CD  . LYS   A 1 99  ? 37.03521 -8.26936  -20.91572 1.000 46.34106  ? 633  LYS   A CD  1 
ATOM   784  C  CE  . LYS   A 1 99  ? 38.38651 -8.36696  -20.22926 1.000 54.95680  ? 633  LYS   A CE  1 
ATOM   785  N  NZ  . LYS   A 1 99  ? 38.55507 -7.31208  -19.19337 1.000 44.54090  ? 633  LYS   A NZ  1 
ATOM   786  N  N   . ILE   A 1 100 ? 32.86011 -12.53423 -22.39053 1.000 44.17708  ? 634  ILE   A N   1 
ATOM   787  C  CA  . ILE   A 1 100 ? 31.44856 -12.78677 -22.66573 1.000 42.08538  ? 634  ILE   A CA  1 
ATOM   788  C  C   . ILE   A 1 100 ? 30.64387 -13.00054 -21.38997 1.000 44.38906  ? 634  ILE   A C   1 
ATOM   789  O  O   . ILE   A 1 100 ? 29.40758 -12.96424 -21.42808 1.000 48.86548  ? 634  ILE   A O   1 
ATOM   790  C  CB  . ILE   A 1 100 ? 31.33556 -13.99123 -23.62737 1.000 43.16119  ? 634  ILE   A CB  1 
ATOM   791  C  CG1 . ILE   A 1 100 ? 32.17217 -13.74001 -24.88448 1.000 43.20131  ? 634  ILE   A CG1 1 
ATOM   792  C  CG2 . ILE   A 1 100 ? 29.88896 -14.27091 -24.02872 1.000 43.60661  ? 634  ILE   A CG2 1 
ATOM   793  C  CD1 . ILE   A 1 100 ? 31.42244 -13.04014 -25.99678 1.000 37.94563  ? 634  ILE   A CD1 1 
ATOM   794  N  N   . GLN   A 1 101 ? 31.32183 -13.18589 -20.25271 1.000 46.38374  ? 635  GLN   A N   1 
ATOM   795  C  CA  . GLN   A 1 101 ? 30.64146 -13.43402 -18.98320 1.000 44.72159  ? 635  GLN   A CA  1 
ATOM   796  C  C   . GLN   A 1 101 ? 29.60058 -12.36281 -18.67687 1.000 50.21192  ? 635  GLN   A C   1 
ATOM   797  O  O   . GLN   A 1 101 ? 28.44727 -12.67346 -18.35625 1.000 53.15131  ? 635  GLN   A O   1 
ATOM   798  C  CB  . GLN   A 1 101 ? 31.66963 -13.50688 -17.85340 1.000 40.48350  ? 635  GLN   A CB  1 
ATOM   799  C  CG  . GLN   A 1 101 ? 31.22981 -14.32439 -16.65088 1.000 42.71068  ? 635  GLN   A CG  1 
ATOM   800  C  CD  . GLN   A 1 101 ? 32.37454 -14.62052 -15.70072 1.000 45.97010  ? 635  GLN   A CD  1 
ATOM   801  O  OE1 . GLN   A 1 101 ? 33.49184 -14.13780 -15.88784 1.000 50.31748  ? 635  GLN   A OE1 1 
ATOM   802  N  NE2 . GLN   A 1 101 ? 32.09893 -15.40862 -14.66823 1.000 44.78576  ? 635  GLN   A NE2 1 
ATOM   803  N  N   . ASN   A 1 102 ? 29.99361 -11.08948 -18.77084 1.000 58.59497  ? 636  ASN   A N   1 
ATOM   804  C  CA  . ASN   A 1 102 ? 29.10590 -10.00143 -18.37312 1.000 49.85510  ? 636  ASN   A CA  1 
ATOM   805  C  C   . ASN   A 1 102 ? 27.87579 -9.88887  -19.26544 1.000 49.83278  ? 636  ASN   A C   1 
ATOM   806  O  O   . ASN   A 1 102 ? 26.88160 -9.28128  -18.85420 1.000 51.43743  ? 636  ASN   A O   1 
ATOM   807  C  CB  . ASN   A 1 102 ? 29.86988 -8.67394  -18.37543 1.000 48.43049  ? 636  ASN   A CB  1 
ATOM   808  C  CG  . ASN   A 1 102 ? 31.28375 -8.81170  -17.84042 1.000 61.73340  ? 636  ASN   A CG  1 
ATOM   809  O  OD1 . ASN   A 1 102 ? 32.24983 -8.80183  -18.60208 1.000 65.68654  ? 636  ASN   A OD1 1 
ATOM   810  N  ND2 . ASN   A 1 102 ? 31.41134 -8.93429  -16.52466 1.000 62.43624  ? 636  ASN   A ND2 1 
ATOM   811  N  N   . LYS   A 1 103 ? 27.91387 -10.46003 -20.46720 1.000 43.30951  ? 637  LYS   A N   1 
ATOM   812  C  CA  . LYS   A 1 103 ? 26.81223 -10.36330 -21.41511 1.000 46.56401  ? 637  LYS   A CA  1 
ATOM   813  C  C   . LYS   A 1 103 ? 25.80870 -11.50342 -21.28371 1.000 51.48306  ? 637  LYS   A C   1 
ATOM   814  O  O   . LYS   A 1 103 ? 24.93577 -11.64294 -22.14687 1.000 52.28022  ? 637  LYS   A O   1 
ATOM   815  C  CB  . LYS   A 1 103 ? 27.35319 -10.31434 -22.84631 1.000 45.71648  ? 637  LYS   A CB  1 
ATOM   816  C  CG  . LYS   A 1 103 ? 28.14646 -9.05815  -23.17050 1.000 55.03862  ? 637  LYS   A CG  1 
ATOM   817  C  CD  . LYS   A 1 103 ? 28.83595 -9.16820  -24.52318 1.000 59.06315  ? 637  LYS   A CD  1 
ATOM   818  C  CE  . LYS   A 1 103 ? 30.30669 -8.78660  -24.43097 1.000 56.33642  ? 637  LYS   A CE  1 
ATOM   819  N  NZ  . LYS   A 1 103 ? 30.60439 -7.53301  -25.17900 1.000 49.66177  ? 637  LYS   A NZ  1 
ATOM   820  N  N   . LEU   A 1 104 ? 25.90839 -12.31600 -20.23207 1.000 49.26331  ? 638  LEU   A N   1 
ATOM   821  C  CA  . LEU   A 1 104 ? 25.04272 -13.47442 -20.06298 1.000 47.82145  ? 638  LEU   A CA  1 
ATOM   822  C  C   . LEU   A 1 104 ? 24.63493 -13.59941 -18.60166 1.000 45.01530  ? 638  LEU   A C   1 
ATOM   823  O  O   . LEU   A 1 104 ? 25.26054 -13.02373 -17.70771 1.000 42.91833  ? 638  LEU   A O   1 
ATOM   824  C  CB  . LEU   A 1 104 ? 25.73198 -14.76652 -20.52418 1.000 41.14853  ? 638  LEU   A CB  1 
ATOM   825  C  CG  . LEU   A 1 104 ? 26.22963 -14.81123 -21.97008 1.000 38.69500  ? 638  LEU   A CG  1 
ATOM   826  C  CD1 . LEU   A 1 104 ? 27.04911 -16.06268 -22.20779 1.000 41.88929  ? 638  LEU   A CD1 1 
ATOM   827  C  CD2 . LEU   A 1 104 ? 25.06708 -14.73850 -22.94381 1.000 47.27611  ? 638  LEU   A CD2 1 
ATOM   828  N  N   . THR   A 1 105 ? 23.57340 -14.36590 -18.37026 1.000 39.90641  ? 639  THR   A N   1 
ATOM   829  C  CA  . THR   A 1 105 ? 23.09588 -14.65378 -17.02677 1.000 42.00959  ? 639  THR   A CA  1 
ATOM   830  C  C   . THR   A 1 105 ? 23.69136 -15.96303 -16.51581 1.000 44.35708  ? 639  THR   A C   1 
ATOM   831  O  O   . THR   A 1 105 ? 24.26368 -16.75257 -17.27137 1.000 42.07641  ? 639  THR   A O   1 
ATOM   832  C  CB  . THR   A 1 105 ? 21.56758 -14.72785 -16.99479 1.000 37.70696  ? 639  THR   A CB  1 
ATOM   833  O  OG1 . THR   A 1 105 ? 21.12910 -15.90685 -17.68275 1.000 43.98101  ? 639  THR   A OG1 1 
ATOM   834  C  CG2 . THR   A 1 105 ? 20.95683 -13.49891 -17.65443 1.000 40.27300  ? 639  THR   A CG2 1 
ATOM   835  N  N   . ASP   A 1 106 ? 23.54458 -16.18463 -15.20609 1.000 46.19502  ? 640  ASP   A N   1 
ATOM   836  C  CA  . ASP   A 1 106 ? 24.09441 -17.39028 -14.59256 1.000 36.31428  ? 640  ASP   A CA  1 
ATOM   837  C  C   . ASP   A 1 106 ? 23.45764 -18.64719 -15.17127 1.000 38.93106  ? 640  ASP   A C   1 
ATOM   838  O  O   . ASP   A 1 106 ? 24.15313 -19.63002 -15.45240 1.000 41.25918  ? 640  ASP   A O   1 
ATOM   839  C  CB  . ASP   A 1 106 ? 23.90401 -17.34362 -13.07740 1.000 41.19567  ? 640  ASP   A CB  1 
ATOM   840  C  CG  . ASP   A 1 106 ? 24.70306 -16.23600 -12.42583 1.000 47.36708  ? 640  ASP   A CG  1 
ATOM   841  O  OD1 . ASP   A 1 106 ? 25.52390 -15.60558 -13.12343 1.000 46.67769  ? 640  ASP   A OD1 1 
ATOM   842  O  OD2 . ASP   A 1 106 ? 24.50985 -15.99722 -11.21550 1.000 49.11436  ? 640  ASP   A OD2 1 
ATOM   843  N  N   . LEU   A 1 107 ? 22.13446 -18.63557 -15.35432 1.000 41.60740  ? 641  LEU   A N   1 
ATOM   844  C  CA  . LEU   A 1 107 ? 21.45618 -19.78952 -15.93716 1.000 39.66549  ? 641  LEU   A CA  1 
ATOM   845  C  C   . LEU   A 1 107 ? 21.94226 -20.05718 -17.35627 1.000 39.79560  ? 641  LEU   A C   1 
ATOM   846  O  O   . LEU   A 1 107 ? 22.11749 -21.21558 -17.75262 1.000 41.80568  ? 641  LEU   A O   1 
ATOM   847  C  CB  . LEU   A 1 107 ? 19.94276 -19.57099 -15.91674 1.000 33.78748  ? 641  LEU   A CB  1 
ATOM   848  C  CG  . LEU   A 1 107 ? 19.26238 -19.49821 -14.54755 1.000 30.40753  ? 641  LEU   A CG  1 
ATOM   849  C  CD1 . LEU   A 1 107 ? 17.74965 -19.55252 -14.69061 1.000 36.57898  ? 641  LEU   A CD1 1 
ATOM   850  C  CD2 . LEU   A 1 107 ? 19.74628 -20.62327 -13.65441 1.000 39.61185  ? 641  LEU   A CD2 1 
ATOM   851  N  N   . GLU   A 1 108 ? 22.17184 -18.99744 -18.13478 1.000 40.46547  ? 642  GLU   A N   1 
ATOM   852  C  CA  . GLU   A 1 108 ? 22.67651 -19.17980 -19.49041 1.000 38.32658  ? 642  GLU   A CA  1 
ATOM   853  C  C   . GLU   A 1 108 ? 24.08978 -19.74428 -19.47469 1.000 39.44815  ? 642  GLU   A C   1 
ATOM   854  O  O   . GLU   A 1 108 ? 24.40573 -20.66041 -20.24326 1.000 36.84933  ? 642  GLU   A O   1 
ATOM   855  C  CB  . GLU   A 1 108 ? 22.63215 -17.85534 -20.24995 1.000 39.28531  ? 642  GLU   A CB  1 
ATOM   856  C  CG  . GLU   A 1 108 ? 21.22966 -17.42799 -20.64368 1.000 49.23622  ? 642  GLU   A CG  1 
ATOM   857  C  CD  . GLU   A 1 108 ? 21.13998 -15.94506 -20.92064 1.000 52.36681  ? 642  GLU   A CD  1 
ATOM   858  O  OE1 . GLU   A 1 108 ? 21.89632 -15.18007 -20.28675 1.000 51.01868  ? 642  GLU   A OE1 1 
ATOM   859  O  OE2 . GLU   A 1 108 ? 20.31669 -15.54245 -21.76950 1.000 50.30152  ? 642  GLU   A OE2 1 
ATOM   860  N  N   . ILE   A 1 109 ? 24.95094 -19.21175 -18.60290 1.000 38.30009  ? 643  ILE   A N   1 
ATOM   861  C  CA  . ILE   A 1 109 ? 26.31227 -19.72583 -18.48559 1.000 35.37569  ? 643  ILE   A CA  1 
ATOM   862  C  C   . ILE   A 1 109 ? 26.29618 -21.15669 -17.96209 1.000 38.20217  ? 643  ILE   A C   1 
ATOM   863  O  O   . ILE   A 1 109 ? 27.01718 -22.02608 -18.46706 1.000 36.19516  ? 643  ILE   A O   1 
ATOM   864  C  CB  . ILE   A 1 109 ? 27.15289 -18.80208 -17.58513 1.000 42.47093  ? 643  ILE   A CB  1 
ATOM   865  C  CG1 . ILE   A 1 109 ? 27.58262 -17.55730 -18.35940 1.000 41.32890  ? 643  ILE   A CG1 1 
ATOM   866  C  CG2 . ILE   A 1 109 ? 28.36916 -19.53539 -17.03875 1.000 40.61164  ? 643  ILE   A CG2 1 
ATOM   867  C  CD1 . ILE   A 1 109 ? 27.71030 -16.32664 -17.49519 1.000 41.00108  ? 643  ILE   A CD1 1 
ATOM   868  N  N   . LEU   A 1 110 ? 25.46795 -21.42480 -16.94733 1.000 36.90859  ? 644  LEU   A N   1 
ATOM   869  C  CA  . LEU   A 1 110 ? 25.35268 -22.77675 -16.40844 1.000 34.77645  ? 644  LEU   A CA  1 
ATOM   870  C  C   . LEU   A 1 110 ? 24.90112 -23.76267 -17.47703 1.000 38.87323  ? 644  LEU   A C   1 
ATOM   871  O  O   . LEU   A 1 110 ? 25.38609 -24.89874 -17.52942 1.000 35.30434  ? 644  LEU   A O   1 
ATOM   872  C  CB  . LEU   A 1 110 ? 24.38414 -22.78068 -15.22609 1.000 33.86195  ? 644  LEU   A CB  1 
ATOM   873  C  CG  . LEU   A 1 110 ? 23.76691 -24.11639 -14.80858 1.000 29.98448  ? 644  LEU   A CG  1 
ATOM   874  C  CD1 . LEU   A 1 110 ? 24.79992 -25.00437 -14.13347 1.000 38.15148  ? 644  LEU   A CD1 1 
ATOM   875  C  CD2 . LEU   A 1 110 ? 22.58068 -23.86979 -13.89257 1.000 37.02537  ? 644  LEU   A CD2 1 
ATOM   876  N  N   . ALA   A 1 111 ? 23.97976 -23.34319 -18.34448 1.000 38.54312  ? 645  ALA   A N   1 
ATOM   877  C  CA  . ALA   A 1 111 ? 23.50011 -24.22407 -19.40178 1.000 36.95139  ? 645  ALA   A CA  1 
ATOM   878  C  C   . ALA   A 1 111 ? 24.51945 -24.36007 -20.52705 1.000 33.33256  ? 645  ALA   A C   1 
ATOM   879  O  O   . ALA   A 1 111 ? 24.64393 -25.43414 -21.12625 1.000 32.12818  ? 645  ALA   A O   1 
ATOM   880  C  CB  . ALA   A 1 111 ? 22.16801 -23.70841 -19.94236 1.000 35.63351  ? 645  ALA   A CB  1 
ATOM   881  N  N   . LEU   A 1 112 ? 25.25383 -23.28518 -20.82788 1.000 36.17318  ? 646  LEU   A N   1 
ATOM   882  C  CA  . LEU   A 1 112 ? 26.25744 -23.34945 -21.88549 1.000 35.54595  ? 646  LEU   A CA  1 
ATOM   883  C  C   . LEU   A 1 112 ? 27.37094 -24.32405 -21.52699 1.000 37.03798  ? 646  LEU   A C   1 
ATOM   884  O  O   . LEU   A 1 112 ? 27.80756 -25.11775 -22.36880 1.000 34.99959  ? 646  LEU   A O   1 
ATOM   885  C  CB  . LEU   A 1 112 ? 26.83446 -21.96009 -22.15052 1.000 34.45708  ? 646  LEU   A CB  1 
ATOM   886  C  CG  . LEU   A 1 112 ? 26.02779 -21.00429 -23.02944 1.000 38.34606  ? 646  LEU   A CG  1 
ATOM   887  C  CD1 . LEU   A 1 112 ? 26.66185 -19.62738 -22.98664 1.000 36.13731  ? 646  LEU   A CD1 1 
ATOM   888  C  CD2 . LEU   A 1 112 ? 25.93732 -21.51527 -24.45785 1.000 35.20655  ? 646  LEU   A CD2 1 
ATOM   889  N  N   . LEU   A 1 113 ? 27.83876 -24.28347 -20.27719 1.000 34.50503  ? 647  LEU   A N   1 
ATOM   890  C  CA  . LEU   A 1 113 ? 28.90317 -25.18841 -19.85553 1.000 31.15519  ? 647  LEU   A CA  1 
ATOM   891  C  C   . LEU   A 1 113 ? 28.44235 -26.64019 -19.88812 1.000 32.53883  ? 647  LEU   A C   1 
ATOM   892  O  O   . LEU   A 1 113 ? 29.19534 -27.52951 -20.30288 1.000 33.07426  ? 647  LEU   A O   1 
ATOM   893  C  CB  . LEU   A 1 113 ? 29.38308 -24.81165 -18.45512 1.000 26.92305  ? 647  LEU   A CB  1 
ATOM   894  C  CG  . LEU   A 1 113 ? 30.64253 -25.51921 -17.94994 1.000 34.83138  ? 647  LEU   A CG  1 
ATOM   895  C  CD1 . LEU   A 1 113 ? 31.71428 -25.56987 -19.03035 1.000 34.36329  ? 647  LEU   A CD1 1 
ATOM   896  C  CD2 . LEU   A 1 113 ? 31.16971 -24.84318 -16.69491 1.000 36.45028  ? 647  LEU   A CD2 1 
ATOM   897  N  N   . ILE   A 1 114 ? 27.20784 -26.89992 -19.45296 1.000 31.89819  ? 648  ILE   A N   1 
ATOM   898  C  CA  . ILE   A 1 114 ? 26.68778 -28.26324 -19.46886 1.000 31.70063  ? 648  ILE   A CA  1 
ATOM   899  C  C   . ILE   A 1 114 ? 26.47596 -28.73467 -20.90207 1.000 31.68702  ? 648  ILE   A C   1 
ATOM   900  O  O   . ILE   A 1 114 ? 26.77977 -29.88399 -21.24450 1.000 33.29423  ? 648  ILE   A O   1 
ATOM   901  C  CB  . ILE   A 1 114 ? 25.39001 -28.34831 -18.64354 1.000 33.28168  ? 648  ILE   A CB  1 
ATOM   902  C  CG1 . ILE   A 1 114 ? 25.67156 -28.05343 -17.16839 1.000 32.40604  ? 648  ILE   A CG1 1 
ATOM   903  C  CG2 . ILE   A 1 114 ? 24.73806 -29.71467 -18.80531 1.000 37.47703  ? 648  ILE   A CG2 1 
ATOM   904  C  CD1 . ILE   A 1 114 ? 24.42474 -27.94599 -16.31659 1.000 30.04200  ? 648  ILE   A CD1 1 
ATOM   905  N  N   . ALA   A 1 115 ? 25.96483 -27.85268 -21.76475 1.000 25.46140  ? 649  ALA   A N   1 
ATOM   906  C  CA  . ALA   A 1 115 ? 25.72245 -28.22449 -23.15544 1.000 31.04231  ? 649  ALA   A CA  1 
ATOM   907  C  C   . ALA   A 1 115 ? 27.02679 -28.46776 -23.90387 1.000 28.43876  ? 649  ALA   A C   1 
ATOM   908  O  O   . ALA   A 1 115 ? 27.12589 -29.41095 -24.69716 1.000 32.53939  ? 649  ALA   A O   1 
ATOM   909  C  CB  . ALA   A 1 115 ? 24.90329 -27.14015 -23.85112 1.000 30.39223  ? 649  ALA   A CB  1 
ATOM   910  N  N   . ALA   A 1 116 ? 28.03382 -27.62181 -23.67145 1.000 28.18397  ? 650  ALA   A N   1 
ATOM   911  C  CA  . ALA   A 1 116 ? 29.32908 -27.80987 -24.31745 1.000 28.24764  ? 650  ALA   A CA  1 
ATOM   912  C  C   . ALA   A 1 116 ? 29.94572 -29.15037 -23.93715 1.000 25.14083  ? 650  ALA   A C   1 
ATOM   913  O  O   . ALA   A 1 116 ? 30.55426 -29.82541 -24.77565 1.000 29.28071  ? 650  ALA   A O   1 
ATOM   914  C  CB  . ALA   A 1 116 ? 30.26747 -26.66185 -23.94747 1.000 28.80888  ? 650  ALA   A CB  1 
ATOM   915  N  N   . LEU   A 1 117 ? 29.79074 -29.55653 -22.67620 1.000 29.97112  ? 651  LEU   A N   1 
ATOM   916  C  CA  . LEU   A 1 117 ? 30.32817 -30.83425 -22.22632 1.000 29.43734  ? 651  LEU   A CA  1 
ATOM   917  C  C   . LEU   A 1 117 ? 29.52241 -32.01494 -22.75095 1.000 30.02927  ? 651  LEU   A C   1 
ATOM   918  O  O   . LEU   A 1 117 ? 30.04857 -33.13161 -22.81619 1.000 29.32584  ? 651  LEU   A O   1 
ATOM   919  C  CB  . LEU   A 1 117 ? 30.36891 -30.87298 -20.69708 1.000 27.49621  ? 651  LEU   A CB  1 
ATOM   920  C  CG  . LEU   A 1 117 ? 31.52775 -30.15730 -20.00232 1.000 28.78415  ? 651  LEU   A CG  1 
ATOM   921  C  CD1 . LEU   A 1 117 ? 31.18236 -29.92285 -18.54489 1.000 34.89270  ? 651  LEU   A CD1 1 
ATOM   922  C  CD2 . LEU   A 1 117 ? 32.81238 -30.96277 -20.12921 1.000 32.66517  ? 651  LEU   A CD2 1 
ATOM   923  N  N   . SER   A 1 118 ? 28.26674 -31.78926 -23.14199 1.000 34.50007  ? 652  SER   A N   1 
ATOM   924  C  CA  . SER   A 1 118 ? 27.34712 -32.86810 -23.46798 1.000 29.38409  ? 652  SER   A CA  1 
ATOM   925  C  C   . SER   A 1 118 ? 26.99218 -32.96348 -24.94286 1.000 29.39535  ? 652  SER   A C   1 
ATOM   926  O  O   . SER   A 1 118 ? 26.45537 -33.99364 -25.36139 1.000 36.63903  ? 652  SER   A O   1 
ATOM   927  C  CB  . SER   A 1 118 ? 26.04251 -32.70548 -22.67491 1.000 27.02684  ? 652  SER   A CB  1 
ATOM   928  O  OG  . SER   A 1 118 ? 26.29592 -32.53255 -21.29267 1.000 25.96848  ? 652  SER   A OG  1 
ATOM   929  N  N   . HIS   A 1 119 ? 27.29051 -31.93269 -25.73704 1.000 28.82686  ? 653  HIS   A N   1 
ATOM   930  C  CA  . HIS   A 1 119 ? 26.70045 -31.77138 -27.06384 1.000 26.22206  ? 653  HIS   A CA  1 
ATOM   931  C  C   . HIS   A 1 119 ? 27.01873 -32.90636 -28.03236 1.000 27.38791  ? 653  HIS   A C   1 
ATOM   932  O  O   . HIS   A 1 119 ? 26.46637 -32.91282 -29.13711 1.000 32.50443  ? 653  HIS   A O   1 
ATOM   933  C  CB  . HIS   A 1 119 ? 27.15329 -30.43985 -27.66855 1.000 27.91372  ? 653  HIS   A CB  1 
ATOM   934  C  CG  . HIS   A 1 119 ? 28.53011 -30.48459 -28.25354 1.000 32.41948  ? 653  HIS   A CG  1 
ATOM   935  N  ND1 . HIS   A 1 119 ? 29.66336 -30.24986 -27.50326 1.000 29.58379  ? 653  HIS   A ND1 1 
ATOM   936  C  CD2 . HIS   A 1 119 ? 28.95690 -30.73004 -29.51587 1.000 28.75833  ? 653  HIS   A CD2 1 
ATOM   937  C  CE1 . HIS   A 1 119 ? 30.72884 -30.35483 -28.27737 1.000 33.61965  ? 653  HIS   A CE1 1 
ATOM   938  N  NE2 . HIS   A 1 119 ? 30.32766 -30.64355 -29.50258 1.000 29.84145  ? 653  HIS   A NE2 1 
ATOM   939  N  N   . ASP   A 1 120 ? 27.88106 -33.85785 -27.66550 1.000 30.93050  ? 654  ASP   A N   1 
ATOM   940  C  CA  . ASP   A 1 120 ? 28.21701 -34.95800 -28.56324 1.000 29.20802  ? 654  ASP   A CA  1 
ATOM   941  C  C   . ASP   A 1 120 ? 28.13722 -36.31423 -27.87217 1.000 33.86965  ? 654  ASP   A C   1 
ATOM   942  O  O   . ASP   A 1 120 ? 28.80669 -37.25839 -28.30367 1.000 35.51291  ? 654  ASP   A O   1 
ATOM   943  C  CB  . ASP   A 1 120 ? 29.61131 -34.76132 -29.16502 1.000 30.06942  ? 654  ASP   A CB  1 
ATOM   944  C  CG  . ASP   A 1 120 ? 29.57965 -33.97811 -30.45841 1.000 34.92890  ? 654  ASP   A CG  1 
ATOM   945  O  OD1 . ASP   A 1 120 ? 28.55317 -34.04747 -31.16465 1.000 36.47538  ? 654  ASP   A OD1 1 
ATOM   946  O  OD2 . ASP   A 1 120 ? 30.57782 -33.29459 -30.76979 1.000 31.35747  ? 654  ASP   A OD2 1 
ATOM   947  N  N   . LEU   A 1 121 ? 27.33025 -36.43189 -26.81966 1.000 30.00353  ? 655  LEU   A N   1 
ATOM   948  C  CA  . LEU   A 1 121 ? 27.30912 -37.64757 -26.01722 1.000 27.21711  ? 655  LEU   A CA  1 
ATOM   949  C  C   . LEU   A 1 121 ? 26.91819 -38.85226 -26.86330 1.000 29.73414  ? 655  LEU   A C   1 
ATOM   950  O  O   . LEU   A 1 121 ? 25.98656 -38.78722 -27.67130 1.000 34.67443  ? 655  LEU   A O   1 
ATOM   951  C  CB  . LEU   A 1 121 ? 26.34007 -37.48974 -24.84582 1.000 29.08049  ? 655  LEU   A CB  1 
ATOM   952  C  CG  . LEU   A 1 121 ? 26.90546 -36.82435 -23.58830 1.000 30.03012  ? 655  LEU   A CG  1 
ATOM   953  C  CD1 . LEU   A 1 121 ? 25.78283 -36.24446 -22.75354 1.000 29.49199  ? 655  LEU   A CD1 1 
ATOM   954  C  CD2 . LEU   A 1 121 ? 27.72830 -37.80385 -22.76724 1.000 30.02944  ? 655  LEU   A CD2 1 
ATOM   955  N  N   . ASP   A 1 122 ? 27.65086 -39.95002 -26.67705 1.000 34.54884  ? 656  ASP   A N   1 
ATOM   956  C  CA  . ASP   A 1 122 ? 27.42402 -41.22339 -27.35375 1.000 34.58976  ? 656  ASP   A CA  1 
ATOM   957  C  C   . ASP   A 1 122 ? 27.64796 -41.13381 -28.86171 1.000 38.27508  ? 656  ASP   A C   1 
ATOM   958  O  O   . ASP   A 1 122 ? 27.07583 -41.91897 -29.62503 1.000 40.90201  ? 656  ASP   A O   1 
ATOM   959  C  CB  . ASP   A 1 122 ? 26.02257 -41.77057 -27.04977 1.000 37.99308  ? 656  ASP   A CB  1 
ATOM   960  C  CG  . ASP   A 1 122 ? 25.91397 -43.26437 -27.28933 1.000 43.11928  ? 656  ASP   A CG  1 
ATOM   961  O  OD1 . ASP   A 1 122 ? 26.84534 -43.99758 -26.89177 1.000 41.28742  ? 656  ASP   A OD1 1 
ATOM   962  O  OD2 . ASP   A 1 122 ? 24.89999 -43.70740 -27.86782 1.000 47.31775  ? 656  ASP   A OD2 1 
ATOM   963  N  N   . HIS   A 1 123 ? 28.47892 -40.19257 -29.30865 1.000 40.86707  ? 657  HIS   A N   1 
ATOM   964  C  CA  . HIS   A 1 123 ? 28.83194 -40.10289 -30.72048 1.000 34.71623  ? 657  HIS   A CA  1 
ATOM   965  C  C   . HIS   A 1 123 ? 29.61294 -41.33788 -31.15564 1.000 32.64813  ? 657  HIS   A C   1 
ATOM   966  O  O   . HIS   A 1 123 ? 30.45362 -41.85539 -30.41550 1.000 43.52572  ? 657  HIS   A O   1 
ATOM   967  C  CB  . HIS   A 1 123 ? 29.65740 -38.83925 -30.97699 1.000 31.00890  ? 657  HIS   A CB  1 
ATOM   968  C  CG  . HIS   A 1 123 ? 29.48034 -38.26273 -32.34725 1.000 29.94576  ? 657  HIS   A CG  1 
ATOM   969  N  ND1 . HIS   A 1 123 ? 29.81222 -38.95409 -33.49278 1.000 30.56631  ? 657  HIS   A ND1 1 
ATOM   970  C  CD2 . HIS   A 1 123 ? 29.02971 -37.05261 -32.75510 1.000 31.90035  ? 657  HIS   A CD2 1 
ATOM   971  C  CE1 . HIS   A 1 123 ? 29.56093 -38.20069 -34.54799 1.000 27.01661  ? 657  HIS   A CE1 1 
ATOM   972  N  NE2 . HIS   A 1 123 ? 29.08620 -37.04161 -34.12786 1.000 32.87006  ? 657  HIS   A NE2 1 
ATOM   973  N  N   . ARG   A 1 124 ? 29.33772 -41.80409 -32.37440 1.000 34.46767  ? 658  ARG   A N   1 
ATOM   974  C  CA  . ARG   A 1 124 ? 29.97324 -43.00176 -32.91175 1.000 39.07731  ? 658  ARG   A CA  1 
ATOM   975  C  C   . ARG   A 1 124 ? 30.85718 -42.71751 -34.11945 1.000 38.91058  ? 658  ARG   A C   1 
ATOM   976  O  O   . ARG   A 1 124 ? 31.29732 -43.66185 -34.78500 1.000 43.52249  ? 658  ARG   A O   1 
ATOM   977  C  CB  . ARG   A 1 124 ? 28.91552 -44.04416 -33.28619 1.000 45.90130  ? 658  ARG   A CB  1 
ATOM   978  C  CG  . ARG   A 1 124 ? 28.32880 -44.79544 -32.10635 1.000 48.50588  ? 658  ARG   A CG  1 
ATOM   979  C  CD  . ARG   A 1 124 ? 27.10465 -45.59094 -32.52622 1.000 52.34217  ? 658  ARG   A CD  1 
ATOM   980  N  NE  . ARG   A 1 124 ? 26.86722 -46.74074 -31.66232 1.000 58.69721  ? 658  ARG   A NE  1 
ATOM   981  C  CZ  . ARG   A 1 124 ? 26.12078 -46.71164 -30.56674 1.000 61.53589  ? 658  ARG   A CZ  1 
ATOM   982  N  NH1 . ARG   A 1 124 ? 25.54735 -45.59413 -30.15110 1.000 63.84731  ? 658  ARG   A NH1 1 
ATOM   983  N  NH2 . ARG   A 1 124 ? 25.94522 -47.83182 -29.87051 1.000 61.62324  ? 658  ARG   A NH2 1 
ATOM   984  N  N   . GLY   A 1 125 ? 31.13258 -41.45350 -34.42155 1.000 36.23149  ? 659  GLY   A N   1 
ATOM   985  C  CA  . GLY   A 1 125 ? 31.89739 -41.12724 -35.60795 1.000 38.25644  ? 659  GLY   A CA  1 
ATOM   986  C  C   . GLY   A 1 125 ? 31.00195 -40.82129 -36.78915 1.000 43.75086  ? 659  GLY   A C   1 
ATOM   987  O  O   . GLY   A 1 125 ? 29.93402 -41.42545 -36.93544 1.000 48.67975  ? 659  GLY   A O   1 
ATOM   988  N  N   . VAL   A 1 126 ? 31.44343 -39.89860 -37.64659 1.000 46.54383  ? 660  VAL   A N   1 
ATOM   989  C  CA  . VAL   A 1 126 ? 30.65126 -39.34696 -38.74519 1.000 51.95480  ? 660  VAL   A CA  1 
ATOM   990  C  C   . VAL   A 1 126 ? 29.98411 -40.42961 -39.58488 1.000 55.49097  ? 660  VAL   A C   1 
ATOM   991  O  O   . VAL   A 1 126 ? 28.94613 -40.18982 -40.21248 1.000 58.27497  ? 660  VAL   A O   1 
ATOM   992  C  CB  . VAL   A 1 126 ? 31.52707 -38.44571 -39.63550 1.000 50.94039  ? 660  VAL   A CB  1 
ATOM   993  C  CG1 . VAL   A 1 126 ? 31.63502 -37.05195 -39.03728 1.000 48.71685  ? 660  VAL   A CG1 1 
ATOM   994  C  CG2 . VAL   A 1 126 ? 32.90677 -39.06075 -39.81019 1.000 52.61219  ? 660  VAL   A CG2 1 
ATOM   995  N  N   . ASN   A 1 127 ? 30.56579 -41.62559 -39.59777 1.000 52.44904  ? 661  ASN   A N   1 
ATOM   996  C  CA  . ASN   A 1 127 ? 30.08172 -42.71045 -40.45151 1.000 53.98210  ? 661  ASN   A CA  1 
ATOM   997  C  C   . ASN   A 1 127 ? 29.24067 -43.68746 -39.63232 1.000 60.40221  ? 661  ASN   A C   1 
ATOM   998  O  O   . ASN   A 1 127 ? 29.60267 -44.84102 -39.39863 1.000 69.10869  ? 661  ASN   A O   1 
ATOM   999  C  CB  . ASN   A 1 127 ? 31.25118 -43.41501 -41.12566 1.000 58.77772  ? 661  ASN   A CB  1 
ATOM   1000 C  CG  . ASN   A 1 127 ? 32.13521 -42.46170 -41.88646 1.000 64.07161  ? 661  ASN   A CG  1 
ATOM   1001 O  OD1 . ASN   A 1 127 ? 31.65988 -41.49264 -42.47445 1.000 59.84825  ? 661  ASN   A OD1 1 
ATOM   1002 N  ND2 . ASN   A 1 127 ? 33.43667 -42.72336 -41.87170 1.000 64.87657  ? 661  ASN   A ND2 1 
ATOM   1003 N  N   . ASN   A 1 128 ? 28.08446 -43.19974 -39.20410 1.000 63.72196  ? 662  ASN   A N   1 
ATOM   1004 C  CA  . ASN   A 1 128 ? 27.11949 -44.04201 -38.50620 1.000 60.12227  ? 662  ASN   A CA  1 
ATOM   1005 C  C   . ASN   A 1 128 ? 25.69615 -43.55900 -38.74486 1.000 62.55552  ? 662  ASN   A C   1 
ATOM   1006 O  O   . ASN   A 1 128 ? 24.74413 -44.32459 -38.59072 1.000 66.13305  ? 662  ASN   A O   1 
ATOM   1007 C  CB  . ASN   A 1 128 ? 27.40352 -44.07752 -37.00567 1.000 57.26886  ? 662  ASN   A CB  1 
ATOM   1008 C  CG  . ASN   A 1 128 ? 28.22104 -45.28619 -36.58971 1.000 56.41774  ? 662  ASN   A CG  1 
ATOM   1009 O  OD1 . ASN   A 1 128 ? 27.79023 -46.07316 -35.74856 1.000 57.81571  ? 662  ASN   A OD1 1 
ATOM   1010 N  ND2 . ASN   A 1 128 ? 29.41396 -45.42662 -37.15651 1.000 47.43585  ? 662  ASN   A ND2 1 
ATOM   1011 N  N   . SER   A 1 145 ? 17.80539 -33.49616 -37.99630 1.000 53.92831  ? 679  SER   A N   1 
ATOM   1012 C  CA  . SER   A 1 145 ? 18.56318 -33.04567 -36.83551 1.000 48.41294  ? 679  SER   A CA  1 
ATOM   1013 C  C   . SER   A 1 145 ? 18.48099 -34.08219 -35.71805 1.000 47.50406  ? 679  SER   A C   1 
ATOM   1014 O  O   . SER   A 1 145 ? 18.40903 -33.73694 -34.53884 1.000 48.52553  ? 679  SER   A O   1 
ATOM   1015 C  CB  . SER   A 1 145 ? 18.04491 -31.69069 -36.34904 1.000 48.63989  ? 679  SER   A CB  1 
ATOM   1016 O  OG  . SER   A 1 145 ? 19.00618 -31.03994 -35.53740 1.000 42.26121  ? 679  SER   A OG  1 
ATOM   1017 N  N   . ILE   A 1 146 ? 18.51308 -35.35936 -36.10569 1.000 47.22816  ? 680  ILE   A N   1 
ATOM   1018 C  CA  . ILE   A 1 146 ? 18.26839 -36.43907 -35.15383 1.000 48.37829  ? 680  ILE   A CA  1 
ATOM   1019 C  C   . ILE   A 1 146 ? 19.45894 -36.62197 -34.21640 1.000 43.77631  ? 680  ILE   A C   1 
ATOM   1020 O  O   . ILE   A 1 146 ? 19.28478 -36.91604 -33.02754 1.000 44.95633  ? 680  ILE   A O   1 
ATOM   1021 C  CB  . ILE   A 1 146 ? 17.92236 -37.73824 -35.90927 1.000 54.33907  ? 680  ILE   A CB  1 
ATOM   1022 C  CG1 . ILE   A 1 146 ? 17.75001 -38.91288 -34.94283 1.000 59.33781  ? 680  ILE   A CG1 1 
ATOM   1023 C  CG2 . ILE   A 1 146 ? 18.97500 -38.05279 -36.95973 1.000 51.06570  ? 680  ILE   A CG2 1 
ATOM   1024 C  CD1 . ILE   A 1 146 ? 16.69589 -38.68585 -33.87965 1.000 47.53454  ? 680  ILE   A CD1 1 
ATOM   1025 N  N   . MET   A 1 147 ? 20.68142 -36.43391 -34.72327 1.000 49.78246  ? 681  MET   A N   1 
ATOM   1026 C  CA  . MET   A 1 147 ? 21.87178 -36.71440 -33.92198 1.000 42.87930  ? 681  MET   A CA  1 
ATOM   1027 C  C   . MET   A 1 147 ? 21.92562 -35.83714 -32.67645 1.000 39.81035  ? 681  MET   A C   1 
ATOM   1028 O  O   . MET   A 1 147 ? 22.19028 -36.32291 -31.57036 1.000 36.93375  ? 681  MET   A O   1 
ATOM   1029 C  CB  . MET   A 1 147 ? 23.13073 -36.52673 -34.77006 1.000 40.30117  ? 681  MET   A CB  1 
ATOM   1030 C  CG  . MET   A 1 147 ? 23.62410 -37.80501 -35.42592 1.000 38.99613  ? 681  MET   A CG  1 
ATOM   1031 S  SD  . MET   A 1 147 ? 23.90780 -39.12065 -34.22691 1.000 51.96051  ? 681  MET   A SD  1 
ATOM   1032 C  CE  . MET   A 1 147 ? 22.69117 -40.32397 -34.75388 1.000 54.57534  ? 681  MET   A CE  1 
ATOM   1033 N  N   . GLU   A 1 148 ? 21.66623 -34.53902 -32.83657 1.000 37.61295  ? 682  GLU   A N   1 
ATOM   1034 C  CA  . GLU   A 1 148 ? 21.73379 -33.62489 -31.70140 1.000 34.88753  ? 682  GLU   A CA  1 
ATOM   1035 C  C   . GLU   A 1 148 ? 20.63085 -33.90210 -30.68808 1.000 38.82776  ? 682  GLU   A C   1 
ATOM   1036 O  O   . GLU   A 1 148 ? 20.83346 -33.70442 -29.48388 1.000 38.37264  ? 682  GLU   A O   1 
ATOM   1037 C  CB  . GLU   A 1 148 ? 21.66216 -32.17629 -32.18814 1.000 35.85673  ? 682  GLU   A CB  1 
ATOM   1038 C  CG  . GLU   A 1 148 ? 22.89976 -31.69912 -32.94459 1.000 37.70344  ? 682  GLU   A CG  1 
ATOM   1039 C  CD  . GLU   A 1 148 ? 23.06019 -32.35013 -34.30986 1.000 37.68929  ? 682  GLU   A CD  1 
ATOM   1040 O  OE1 . GLU   A 1 148 ? 22.09446 -32.97483 -34.79797 1.000 43.29939  ? 682  GLU   A OE1 1 
ATOM   1041 O  OE2 . GLU   A 1 148 ? 24.15965 -32.24522 -34.89142 1.000 35.67193  ? 682  GLU   A OE2 1 
ATOM   1042 N  N   . HIS   A 1 149 ? 19.46204 -34.35241 -31.15222 1.000 42.01417  ? 683  HIS   A N   1 
ATOM   1043 C  CA  . HIS   A 1 149 ? 18.40433 -34.74794 -30.22893 1.000 35.87742  ? 683  HIS   A CA  1 
ATOM   1044 C  C   . HIS   A 1 149 ? 18.81868 -35.95753 -29.40357 1.000 30.80487  ? 683  HIS   A C   1 
ATOM   1045 O  O   . HIS   A 1 149 ? 18.42442 -36.08064 -28.23805 1.000 34.81543  ? 683  HIS   A O   1 
ATOM   1046 C  CB  . HIS   A 1 149 ? 17.11600 -35.04319 -30.99893 1.000 34.62754  ? 683  HIS   A CB  1 
ATOM   1047 C  CG  . HIS   A 1 149 ? 16.32810 -33.82047 -31.35395 1.000 37.02559  ? 683  HIS   A CG  1 
ATOM   1048 N  ND1 . HIS   A 1 149 ? 15.67319 -33.05567 -30.41265 1.000 32.55701  ? 683  HIS   A ND1 1 
ATOM   1049 C  CD2 . HIS   A 1 149 ? 16.08911 -33.23128 -32.54951 1.000 42.49327  ? 683  HIS   A CD2 1 
ATOM   1050 C  CE1 . HIS   A 1 149 ? 15.06399 -32.04889 -31.01335 1.000 34.13876  ? 683  HIS   A CE1 1 
ATOM   1051 N  NE2 . HIS   A 1 149 ? 15.30098 -32.13214 -32.31010 1.000 43.49677  ? 683  HIS   A NE2 1 
ATOM   1052 N  N   . HIS   A 1 150 ? 19.61045 -36.85871 -29.98925 1.000 32.88893  ? 684  HIS   A N   1 
ATOM   1053 C  CA  . HIS   A 1 150 ? 20.13723 -37.98723 -29.22963 1.000 35.78042  ? 684  HIS   A CA  1 
ATOM   1054 C  C   . HIS   A 1 150 ? 21.14866 -37.52511 -28.18760 1.000 36.52895  ? 684  HIS   A C   1 
ATOM   1055 O  O   . HIS   A 1 150 ? 21.20203 -38.07347 -27.08020 1.000 34.77313  ? 684  HIS   A O   1 
ATOM   1056 C  CB  . HIS   A 1 150 ? 20.76911 -39.00618 -30.17845 1.000 35.10630  ? 684  HIS   A CB  1 
ATOM   1057 C  CG  . HIS   A 1 150 ? 21.35118 -40.20019 -29.48673 1.000 36.20574  ? 684  HIS   A CG  1 
ATOM   1058 N  ND1 . HIS   A 1 150 ? 20.58070 -41.11993 -28.80846 1.000 41.43451  ? 684  HIS   A ND1 1 
ATOM   1059 C  CD2 . HIS   A 1 150 ? 22.63225 -40.62214 -29.36648 1.000 31.89874  ? 684  HIS   A CD2 1 
ATOM   1060 C  CE1 . HIS   A 1 150 ? 21.36172 -42.05867 -28.30365 1.000 36.12078  ? 684  HIS   A CE1 1 
ATOM   1061 N  NE2 . HIS   A 1 150 ? 22.61134 -41.77972 -28.62732 1.000 32.90448  ? 684  HIS   A NE2 1 
ATOM   1062 N  N   . HIS   A 1 151 ? 21.95357 -36.51201 -28.52098 1.000 33.74897  ? 685  HIS   A N   1 
ATOM   1063 C  CA  . HIS   A 1 151 ? 22.95215 -36.01675 -27.57820 1.000 34.17956  ? 685  HIS   A CA  1 
ATOM   1064 C  C   . HIS   A 1 151 ? 22.29990 -35.34823 -26.37459 1.000 36.93523  ? 685  HIS   A C   1 
ATOM   1065 O  O   . HIS   A 1 151 ? 22.75007 -35.53296 -25.23741 1.000 35.29860  ? 685  HIS   A O   1 
ATOM   1066 C  CB  . HIS   A 1 151 ? 23.90331 -35.04984 -28.28115 1.000 30.03645  ? 685  HIS   A CB  1 
ATOM   1067 C  CG  . HIS   A 1 151 ? 24.63381 -35.65833 -29.43607 1.000 34.59781  ? 685  HIS   A CG  1 
ATOM   1068 N  ND1 . HIS   A 1 151 ? 25.15299 -36.93452 -29.39602 1.000 31.56507  ? 685  HIS   A ND1 1 
ATOM   1069 C  CD2 . HIS   A 1 151 ? 24.93307 -35.16756 -30.66213 1.000 31.96656  ? 685  HIS   A CD2 1 
ATOM   1070 C  CE1 . HIS   A 1 151 ? 25.73966 -37.20431 -30.54823 1.000 27.49231  ? 685  HIS   A CE1 1 
ATOM   1071 N  NE2 . HIS   A 1 151 ? 25.62067 -36.14887 -31.33381 1.000 31.03234  ? 685  HIS   A NE2 1 
ATOM   1072 N  N   . PHE   A 1 152 ? 21.24492 -34.56181 -26.60142 1.000 35.58513  ? 686  PHE   A N   1 
ATOM   1073 C  CA  . PHE   A 1 152 ? 20.52169 -33.97565 -25.47825 1.000 33.95366  ? 686  PHE   A CA  1 
ATOM   1074 C  C   . PHE   A 1 152 ? 19.80896 -35.04863 -24.66647 1.000 34.63683  ? 686  PHE   A C   1 
ATOM   1075 O  O   . PHE   A 1 152 ? 19.72572 -34.95121 -23.43655 1.000 35.09211  ? 686  PHE   A O   1 
ATOM   1076 C  CB  . PHE   A 1 152 ? 19.51679 -32.93570 -25.96912 1.000 37.44990  ? 686  PHE   A CB  1 
ATOM   1077 C  CG  . PHE   A 1 152 ? 18.54840 -32.49507 -24.90973 1.000 37.82758  ? 686  PHE   A CG  1 
ATOM   1078 C  CD1 . PHE   A 1 152 ? 18.95686 -31.64657 -23.89476 1.000 30.86999  ? 686  PHE   A CD1 1 
ATOM   1079 C  CD2 . PHE   A 1 152 ? 17.23725 -32.94614 -24.91514 1.000 35.08861  ? 686  PHE   A CD2 1 
ATOM   1080 C  CE1 . PHE   A 1 152 ? 18.07517 -31.24402 -22.91137 1.000 37.19652  ? 686  PHE   A CE1 1 
ATOM   1081 C  CE2 . PHE   A 1 152 ? 16.34948 -32.54747 -23.93347 1.000 33.93264  ? 686  PHE   A CE2 1 
ATOM   1082 C  CZ  . PHE   A 1 152 ? 16.77070 -31.69439 -22.92998 1.000 36.88561  ? 686  PHE   A CZ  1 
ATOM   1083 N  N   . ASP   A 1 153 ? 19.27384 -36.06973 -25.34085 1.000 32.97415  ? 687  ASP   A N   1 
ATOM   1084 C  CA  . ASP   A 1 153 ? 18.65100 -37.18837 -24.64088 1.000 34.33970  ? 687  ASP   A CA  1 
ATOM   1085 C  C   . ASP   A 1 153 ? 19.62159 -37.81852 -23.65052 1.000 35.38481  ? 687  ASP   A C   1 
ATOM   1086 O  O   . ASP   A 1 153 ? 19.27565 -38.06430 -22.48909 1.000 32.78877  ? 687  ASP   A O   1 
ATOM   1087 C  CB  . ASP   A 1 153 ? 18.16645 -38.22761 -25.65290 1.000 41.03400  ? 687  ASP   A CB  1 
ATOM   1088 C  CG  . ASP   A 1 153 ? 16.77751 -38.74561 -25.34185 1.000 46.13471  ? 687  ASP   A CG  1 
ATOM   1089 O  OD1 . ASP   A 1 153 ? 16.65343 -39.63377 -24.47226 1.000 50.87466  ? 687  ASP   A OD1 1 
ATOM   1090 O  OD2 . ASP   A 1 153 ? 15.81093 -38.27511 -25.97710 1.000 52.65593  ? 687  ASP   A OD2 1 
ATOM   1091 N  N   . GLN   A 1 154 ? 20.85246 -38.07954 -24.09769 1.000 37.48712  ? 688  GLN   A N   1 
ATOM   1092 C  CA  . GLN   A 1 154 ? 21.86074 -38.64511 -23.20828 1.000 36.40145  ? 688  GLN   A CA  1 
ATOM   1093 C  C   . GLN   A 1 154 ? 22.27398 -37.64294 -22.13839 1.000 36.23596  ? 688  GLN   A C   1 
ATOM   1094 O  O   . GLN   A 1 154 ? 22.55608 -38.02652 -20.99684 1.000 37.63299  ? 688  GLN   A O   1 
ATOM   1095 C  CB  . GLN   A 1 154 ? 23.07134 -39.10109 -24.01992 1.000 34.97678  ? 688  GLN   A CB  1 
ATOM   1096 C  CG  . GLN   A 1 154 ? 22.75576 -40.21576 -24.99737 1.000 35.40428  ? 688  GLN   A CG  1 
ATOM   1097 C  CD  . GLN   A 1 154 ? 23.04278 -41.58924 -24.43006 1.000 43.56179  ? 688  GLN   A CD  1 
ATOM   1098 O  OE1 . GLN   A 1 154 ? 24.16142 -41.87628 -24.00511 1.000 48.07810  ? 688  GLN   A OE1 1 
ATOM   1099 N  NE2 . GLN   A 1 154 ? 22.02896 -42.44582 -24.41345 1.000 41.23695  ? 688  GLN   A NE2 1 
ATOM   1100 N  N   . CYS   A 1 155 ? 22.31974 -36.35457 -22.49086 1.000 32.55057  ? 689  CYS   A N   1 
ATOM   1101 C  CA  . CYS   A 1 155 ? 22.58634 -35.32362 -21.49291 1.000 27.50316  ? 689  CYS   A CA  1 
ATOM   1102 C  C   . CYS   A 1 155 ? 21.50617 -35.30836 -20.42202 1.000 35.75595  ? 689  CYS   A C   1 
ATOM   1103 O  O   . CYS   A 1 155 ? 21.80225 -35.17377 -19.22911 1.000 36.82291  ? 689  CYS   A O   1 
ATOM   1104 C  CB  . CYS   A 1 155 ? 22.68791 -33.95387 -22.16298 1.000 29.52035  ? 689  CYS   A CB  1 
ATOM   1105 S  SG  . CYS   A 1 155 ? 22.80593 -32.56854 -21.00914 1.000 31.93249  ? 689  CYS   A SG  1 
ATOM   1106 N  N   . LEU   A 1 156 ? 20.24531 -35.44963 -20.83111 1.000 33.49226  ? 690  LEU   A N   1 
ATOM   1107 C  CA  . LEU   A 1 156 ? 19.14762 -35.45281 -19.87182 1.000 31.38174  ? 690  LEU   A CA  1 
ATOM   1108 C  C   . LEU   A 1 156 ? 19.18344 -36.69389 -18.98886 1.000 34.96153  ? 690  LEU   A C   1 
ATOM   1109 O  O   . LEU   A 1 156 ? 18.93941 -36.60914 -17.77927 1.000 31.70553  ? 690  LEU   A O   1 
ATOM   1110 C  CB  . LEU   A 1 156 ? 17.81711 -35.36466 -20.61217 1.000 35.69205  ? 690  LEU   A CB  1 
ATOM   1111 C  CG  . LEU   A 1 156 ? 16.57333 -35.19555 -19.74346 1.000 26.65046  ? 690  LEU   A CG  1 
ATOM   1112 C  CD1 . LEU   A 1 156 ? 16.69948 -33.99051 -18.82457 1.000 29.73158  ? 690  LEU   A CD1 1 
ATOM   1113 C  CD2 . LEU   A 1 156 ? 15.35516 -35.08013 -20.62810 1.000 29.60416  ? 690  LEU   A CD2 1 
ATOM   1114 N  N   . MET   A 1 157 ? 19.48517 -37.85549 -19.57505 1.000 33.56879  ? 691  MET   A N   1 
ATOM   1115 C  CA  . MET   A 1 157 ? 19.52516 -39.08930 -18.79561 1.000 35.77190  ? 691  MET   A CA  1 
ATOM   1116 C  C   . MET   A 1 157 ? 20.59184 -39.02156 -17.70898 1.000 40.44329  ? 691  MET   A C   1 
ATOM   1117 O  O   . MET   A 1 157 ? 20.37042 -39.47681 -16.58002 1.000 39.53316  ? 691  MET   A O   1 
ATOM   1118 C  CB  . MET   A 1 157 ? 19.77275 -40.28279 -19.71850 1.000 35.47892  ? 691  MET   A CB  1 
ATOM   1119 C  CG  . MET   A 1 157 ? 20.04806 -41.58855 -18.99038 1.000 48.33460  ? 691  MET   A CG  1 
ATOM   1120 S  SD  . MET   A 1 157 ? 21.79871 -42.02219 -18.93645 1.000 59.40792  ? 691  MET   A SD  1 
ATOM   1121 C  CE  . MET   A 1 157 ? 22.24432 -41.85828 -20.66268 1.000 42.37200  ? 691  MET   A CE  1 
ATOM   1122 N  N   . ILE   A 1 158 ? 21.75473 -38.44988 -18.03015 1.000 40.97979  ? 692  ILE   A N   1 
ATOM   1123 C  CA  . ILE   A 1 158 ? 22.81410 -38.30584 -17.03717 1.000 37.49735  ? 692  ILE   A CA  1 
ATOM   1124 C  C   . ILE   A 1 158 ? 22.42073 -37.27886 -15.98152 1.000 40.08752  ? 692  ILE   A C   1 
ATOM   1125 O  O   . ILE   A 1 158 ? 22.66590 -37.47358 -14.78461 1.000 42.03630  ? 692  ILE   A O   1 
ATOM   1126 C  CB  . ILE   A 1 158 ? 24.14029 -37.93794 -17.72859 1.000 36.87654  ? 692  ILE   A CB  1 
ATOM   1127 C  CG1 . ILE   A 1 158 ? 24.58272 -39.05900 -18.67209 1.000 32.49248  ? 692  ILE   A CG1 1 
ATOM   1128 C  CG2 . ILE   A 1 158 ? 25.22238 -37.65000 -16.69862 1.000 33.30584  ? 692  ILE   A CG2 1 
ATOM   1129 C  CD1 . ILE   A 1 158 ? 25.91063 -38.79768 -19.35727 1.000 32.94581  ? 692  ILE   A CD1 1 
ATOM   1130 N  N   . LEU   A 1 159 ? 21.79767 -36.17457 -16.40311 1.000 36.53122  ? 693  LEU   A N   1 
ATOM   1131 C  CA  . LEU   A 1 159 ? 21.35740 -35.15604 -15.45552 1.000 36.05383  ? 693  LEU   A CA  1 
ATOM   1132 C  C   . LEU   A 1 159 ? 20.33093 -35.68929 -14.46654 1.000 34.91384  ? 693  LEU   A C   1 
ATOM   1133 O  O   . LEU   A 1 159 ? 20.17198 -35.11189 -13.38636 1.000 39.03069  ? 693  LEU   A O   1 
ATOM   1134 C  CB  . LEU   A 1 159 ? 20.77135 -33.95452 -16.19935 1.000 38.96745  ? 693  LEU   A CB  1 
ATOM   1135 C  CG  . LEU   A 1 159 ? 21.75010 -32.90811 -16.73549 1.000 35.42514  ? 693  LEU   A CG  1 
ATOM   1136 C  CD1 . LEU   A 1 159 ? 21.01839 -31.87448 -17.58021 1.000 31.46730  ? 693  LEU   A CD1 1 
ATOM   1137 C  CD2 . LEU   A 1 159 ? 22.50106 -32.23800 -15.59463 1.000 40.08360  ? 693  LEU   A CD2 1 
ATOM   1138 N  N   . ASN   A 1 160 ? 19.62959 -36.76764 -14.81011 1.000 34.50526  ? 694  ASN   A N   1 
ATOM   1139 C  CA  . ASN   A 1 160 ? 18.64057 -37.37353 -13.93062 1.000 35.65935  ? 694  ASN   A CA  1 
ATOM   1140 C  C   . ASN   A 1 160 ? 19.14196 -38.64383 -13.25769 1.000 38.40674  ? 694  ASN   A C   1 
ATOM   1141 O  O   . ASN   A 1 160 ? 18.37013 -39.29658 -12.54715 1.000 42.61815  ? 694  ASN   A O   1 
ATOM   1142 C  CB  . ASN   A 1 160 ? 17.35664 -37.67650 -14.71088 1.000 38.93521  ? 694  ASN   A CB  1 
ATOM   1143 C  CG  . ASN   A 1 160 ? 16.58631 -36.42426 -15.06739 1.000 36.99229  ? 694  ASN   A CG  1 
ATOM   1144 O  OD1 . ASN   A 1 160 ? 16.71050 -35.39757 -14.40057 1.000 49.59718  ? 694  ASN   A OD1 1 
ATOM   1145 N  ND2 . ASN   A 1 160 ? 15.78840 -36.49907 -16.12689 1.000 34.80297  ? 694  ASN   A ND2 1 
ATOM   1146 N  N   . SER   A 1 161 ? 20.40489 -39.00800 -13.46054 1.000 36.58547  ? 695  SER   A N   1 
ATOM   1147 C  CA  . SER   A 1 161 ? 20.93580 -40.21264 -12.84327 1.000 35.73665  ? 695  SER   A CA  1 
ATOM   1148 C  C   . SER   A 1 161 ? 21.16338 -39.98096 -11.35111 1.000 42.32497  ? 695  SER   A C   1 
ATOM   1149 O  O   . SER   A 1 161 ? 21.61746 -38.90266 -10.95327 1.000 39.50848  ? 695  SER   A O   1 
ATOM   1150 C  CB  . SER   A 1 161 ? 22.24486 -40.62709 -13.51253 1.000 33.03310  ? 695  SER   A CB  1 
ATOM   1151 O  OG  . SER   A 1 161 ? 21.99986 -41.35865 -14.69927 1.000 38.54943  ? 695  SER   A OG  1 
ATOM   1152 N  N   . PRO   A 1 162 ? 20.83331 -40.95713 -10.50539 1.000 45.71423  ? 696  PRO   A N   1 
ATOM   1153 C  CA  . PRO   A 1 162 ? 21.08796 -40.81155 -9.06670  1.000 40.18146  ? 696  PRO   A CA  1 
ATOM   1154 C  C   . PRO   A 1 162 ? 22.54361 -40.45874 -8.78729  1.000 42.64840  ? 696  PRO   A C   1 
ATOM   1155 O  O   . PRO   A 1 162 ? 23.46582 -41.01964 -9.38406  1.000 43.02731  ? 696  PRO   A O   1 
ATOM   1156 C  CB  . PRO   A 1 162 ? 20.72751 -42.18856 -8.49817  1.000 34.33418  ? 696  PRO   A CB  1 
ATOM   1157 C  CG  . PRO   A 1 162 ? 19.86725 -42.85175 -9.53037  1.000 36.29925  ? 696  PRO   A CG  1 
ATOM   1158 C  CD  . PRO   A 1 162 ? 19.92028 -42.07078 -10.81034 1.000 36.93987  ? 696  PRO   A CD  1 
ATOM   1159 N  N   . GLY   A 1 163 ? 22.74357 -39.50970 -7.87254  1.000 38.45444  ? 697  GLY   A N   1 
ATOM   1160 C  CA  . GLY   A 1 163 ? 24.06774 -39.05134 -7.51073  1.000 38.15461  ? 697  GLY   A CA  1 
ATOM   1161 C  C   . GLY   A 1 163 ? 24.73910 -38.14951 -8.52327  1.000 44.96165  ? 697  GLY   A C   1 
ATOM   1162 O  O   . GLY   A 1 163 ? 25.87401 -37.71549 -8.28211  1.000 49.28285  ? 697  GLY   A O   1 
ATOM   1163 N  N   . ASN   A 1 164 ? 24.08169 -37.84915 -9.64409  1.000 43.56809  ? 698  ASN   A N   1 
ATOM   1164 C  CA  . ASN   A 1 164 ? 24.65917 -37.02256 -10.69435 1.000 37.30924  ? 698  ASN   A CA  1 
ATOM   1165 C  C   . ASN   A 1 164 ? 23.91916 -35.70677 -10.88717 1.000 38.27332  ? 698  ASN   A C   1 
ATOM   1166 O  O   . ASN   A 1 164 ? 24.33953 -34.89215 -11.71557 1.000 43.18329  ? 698  ASN   A O   1 
ATOM   1167 C  CB  . ASN   A 1 164 ? 24.68405 -37.78985 -12.02366 1.000 35.82064  ? 698  ASN   A CB  1 
ATOM   1168 C  CG  . ASN   A 1 164 ? 25.56126 -39.03218 -11.97300 1.000 41.12794  ? 698  ASN   A CG  1 
ATOM   1169 O  OD1 . ASN   A 1 164 ? 26.60510 -39.08951 -12.61963 1.000 38.57462  ? 698  ASN   A OD1 1 
ATOM   1170 N  ND2 . ASN   A 1 164 ? 25.12670 -40.04153 -11.22576 1.000 43.80158  ? 698  ASN   A ND2 1 
ATOM   1171 N  N   . GLN   A 1 165 ? 22.83442 -35.47570 -10.14507 1.000 37.45727  ? 699  GLN   A N   1 
ATOM   1172 C  CA  . GLN   A 1 165 ? 21.94495 -34.33638 -10.37531 1.000 39.61669  ? 699  GLN   A CA  1 
ATOM   1173 C  C   . GLN   A 1 165 ? 22.61434 -33.06118 -9.86591  1.000 34.10216  ? 699  GLN   A C   1 
ATOM   1174 O  O   . GLN   A 1 165 ? 22.39906 -32.60413 -8.74082  1.000 35.48187  ? 699  GLN   A O   1 
ATOM   1175 C  CB  . GLN   A 1 165 ? 20.59541 -34.57821 -9.70873  1.000 37.44788  ? 699  GLN   A CB  1 
ATOM   1176 C  CG  . GLN   A 1 165 ? 19.79345 -35.70488 -10.35085 1.000 31.73540  ? 699  GLN   A CG  1 
ATOM   1177 C  CD  . GLN   A 1 165 ? 19.02592 -36.53822 -9.34242  1.000 37.37912  ? 699  GLN   A CD  1 
ATOM   1178 O  OE1 . GLN   A 1 165 ? 18.33880 -36.00598 -8.47274  1.000 44.83724  ? 699  GLN   A OE1 1 
ATOM   1179 N  NE2 . GLN   A 1 165 ? 19.13990 -37.85801 -9.45746  1.000 46.51032  ? 699  GLN   A NE2 1 
ATOM   1180 N  N   . ILE   A 1 166 ? 23.44310 -32.46911 -10.73021 1.000 36.90296  ? 700  ILE   A N   1 
ATOM   1181 C  CA  . ILE   A 1 166 ? 24.12960 -31.22858 -10.38742 1.000 34.08658  ? 700  ILE   A CA  1 
ATOM   1182 C  C   . ILE   A 1 166 ? 23.20666 -30.02195 -10.41357 1.000 36.93199  ? 700  ILE   A C   1 
ATOM   1183 O  O   . ILE   A 1 166 ? 23.56909 -28.96324 -9.88709  1.000 40.01035  ? 700  ILE   A O   1 
ATOM   1184 C  CB  . ILE   A 1 166 ? 25.32037 -30.98447 -11.33612 1.000 34.68896  ? 700  ILE   A CB  1 
ATOM   1185 C  CG1 . ILE   A 1 166 ? 24.86032 -31.05051 -12.79361 1.000 34.10005  ? 700  ILE   A CG1 1 
ATOM   1186 C  CG2 . ILE   A 1 166 ? 26.42345 -31.98732 -11.07148 1.000 34.00759  ? 700  ILE   A CG2 1 
ATOM   1187 C  CD1 . ILE   A 1 166 ? 25.67504 -30.19067 -13.73003 1.000 34.46689  ? 700  ILE   A CD1 1 
ATOM   1188 N  N   . LEU   A 1 167 ? 22.02182 -30.15260 -11.00746 1.000 38.86839  ? 701  LEU   A N   1 
ATOM   1189 C  CA  . LEU   A 1 167 ? 21.05987 -29.06282 -11.08660 1.000 37.55128  ? 701  LEU   A CA  1 
ATOM   1190 C  C   . LEU   A 1 167 ? 19.97264 -29.15424 -10.01820 1.000 39.40277  ? 701  LEU   A C   1 
ATOM   1191 O  O   . LEU   A 1 167 ? 18.96586 -28.44290 -10.10841 1.000 38.51204  ? 701  LEU   A O   1 
ATOM   1192 C  CB  . LEU   A 1 167 ? 20.42821 -29.02289 -12.47973 1.000 35.89763  ? 701  LEU   A CB  1 
ATOM   1193 C  CG  . LEU   A 1 167 ? 21.38634 -28.80401 -13.65416 1.000 35.48020  ? 701  LEU   A CG  1 
ATOM   1194 C  CD1 . LEU   A 1 167 ? 20.67738 -29.02434 -14.98223 1.000 33.32300  ? 701  LEU   A CD1 1 
ATOM   1195 C  CD2 . LEU   A 1 167 ? 21.99933 -27.41672 -13.58834 1.000 32.16504  ? 701  LEU   A CD2 1 
ATOM   1196 N  N   . SER   A 1 168 ? 20.15913 -30.00380 -9.00393  1.000 38.64134  ? 702  SER   A N   1 
ATOM   1197 C  CA  . SER   A 1 168 ? 19.17588 -30.13658 -7.93377  1.000 37.07220  ? 702  SER   A CA  1 
ATOM   1198 C  C   . SER   A 1 168 ? 19.03590 -28.87025 -7.10020  1.000 37.57527  ? 702  SER   A C   1 
ATOM   1199 O  O   . SER   A 1 168 ? 17.96810 -28.64289 -6.52181  1.000 41.48874  ? 702  SER   A O   1 
ATOM   1200 C  CB  . SER   A 1 168 ? 19.53996 -31.31692 -7.03355  1.000 35.79192  ? 702  SER   A CB  1 
ATOM   1201 O  OG  . SER   A 1 168 ? 20.62734 -30.99469 -6.18443  1.000 41.61774  ? 702  SER   A OG  1 
ATOM   1202 N  N   . GLY   A 1 169 ? 20.07203 -28.03571 -7.04186  1.000 41.42575  ? 703  GLY   A N   1 
ATOM   1203 C  CA  . GLY   A 1 169 ? 19.98320 -26.79280 -6.30063  1.000 38.69807  ? 703  GLY   A CA  1 
ATOM   1204 C  C   . GLY   A 1 169 ? 19.10570 -25.74452 -6.94278  1.000 36.04809  ? 703  GLY   A C   1 
ATOM   1205 O  O   . GLY   A 1 169 ? 18.86593 -24.70304 -6.32370  1.000 43.11068  ? 703  GLY   A O   1 
ATOM   1206 N  N   . LEU   A 1 170 ? 18.62871 -25.99044 -8.15820  1.000 39.27404  ? 704  LEU   A N   1 
ATOM   1207 C  CA  . LEU   A 1 170 ? 17.77658 -25.05180 -8.86953  1.000 36.13111  ? 704  LEU   A CA  1 
ATOM   1208 C  C   . LEU   A 1 170 ? 16.31373 -25.30549 -8.52873  1.000 39.27946  ? 704  LEU   A C   1 
ATOM   1209 O  O   . LEU   A 1 170 ? 15.91024 -26.43614 -8.24558  1.000 43.32274  ? 704  LEU   A O   1 
ATOM   1210 C  CB  . LEU   A 1 170 ? 17.97645 -25.17037 -10.38341 1.000 36.35717  ? 704  LEU   A CB  1 
ATOM   1211 C  CG  . LEU   A 1 170 ? 19.22133 -24.58917 -11.06665 1.000 37.20358  ? 704  LEU   A CG  1 
ATOM   1212 C  CD1 . LEU   A 1 170 ? 20.50842 -25.25119 -10.59958 1.000 41.75515  ? 704  LEU   A CD1 1 
ATOM   1213 C  CD2 . LEU   A 1 170 ? 19.08793 -24.68246 -12.58472 1.000 34.03259  ? 704  LEU   A CD2 1 
ATOM   1214 N  N   . SER   A 1 171 ? 15.51726 -24.23925 -8.56174  1.000 40.02183  ? 705  SER   A N   1 
ATOM   1215 C  CA  . SER   A 1 171 ? 14.07403 -24.38223 -8.43972  1.000 41.62179  ? 705  SER   A CA  1 
ATOM   1216 C  C   . SER   A 1 171 ? 13.51398 -25.01077 -9.71561  1.000 45.64366  ? 705  SER   A C   1 
ATOM   1217 O  O   . SER   A 1 171 ? 14.22937 -25.23769 -10.69435 1.000 47.19813  ? 705  SER   A O   1 
ATOM   1218 C  CB  . SER   A 1 171 ? 13.42803 -23.02784 -8.15963  1.000 43.97076  ? 705  SER   A CB  1 
ATOM   1219 O  OG  . SER   A 1 171 ? 13.72207 -22.10253 -9.19186  1.000 39.36192  ? 705  SER   A OG  1 
ATOM   1220 N  N   . ILE   A 1 172 ? 12.21009 -25.29355 -9.71475  1.000 48.98762  ? 706  ILE   A N   1 
ATOM   1221 C  CA  . ILE   A 1 172 ? 11.61156 -25.92679 -10.88599 1.000 45.60707  ? 706  ILE   A CA  1 
ATOM   1222 C  C   . ILE   A 1 172 ? 11.53259 -24.93991 -12.04657 1.000 45.02656  ? 706  ILE   A C   1 
ATOM   1223 O  O   . ILE   A 1 172 ? 11.69857 -25.31982 -13.21212 1.000 47.14683  ? 706  ILE   A O   1 
ATOM   1224 C  CB  . ILE   A 1 172 ? 10.23459 -26.52510 -10.53520 1.000 42.97663  ? 706  ILE   A CB  1 
ATOM   1225 C  CG1 . ILE   A 1 172 ? 9.69089  -27.35964 -11.70085 1.000 40.51993  ? 706  ILE   A CG1 1 
ATOM   1226 C  CG2 . ILE   A 1 172 ? 9.24289  -25.44197 -10.12552 1.000 41.77280  ? 706  ILE   A CG2 1 
ATOM   1227 C  CD1 . ILE   A 1 172 ? 10.71901 -28.25400 -12.35989 1.000 40.58629  ? 706  ILE   A CD1 1 
ATOM   1228 N  N   . GLU   A 1 173 ? 11.29906 -23.65821 -11.75349 1.000 45.48144  ? 707  GLU   A N   1 
ATOM   1229 C  CA  . GLU   A 1 173 ? 11.31713 -22.65603 -12.81334 1.000 42.96539  ? 707  GLU   A CA  1 
ATOM   1230 C  C   . GLU   A 1 173 ? 12.72773 -22.47406 -13.35787 1.000 47.68859  ? 707  GLU   A C   1 
ATOM   1231 O  O   . GLU   A 1 173 ? 12.93029 -22.40159 -14.57569 1.000 51.92724  ? 707  GLU   A O   1 
ATOM   1232 C  CB  . GLU   A 1 173 ? 10.76076 -21.32544 -12.30496 1.000 46.67758  ? 707  GLU   A CB  1 
ATOM   1233 C  CG  . GLU   A 1 173 ? 9.59285  -21.44431 -11.33772 1.000 51.53655  ? 707  GLU   A CG  1 
ATOM   1234 C  CD  . GLU   A 1 173 ? 10.03181 -21.45610 -9.88610  1.000 59.64916  ? 707  GLU   A CD  1 
ATOM   1235 O  OE1 . GLU   A 1 173 ? 10.31436 -20.36990 -9.33995  1.000 63.94834  ? 707  GLU   A OE1 1 
ATOM   1236 O  OE2 . GLU   A 1 173 ? 10.08617 -22.54607 -9.28533  1.000 58.81294  ? 707  GLU   A OE2 1 
ATOM   1237 N  N   . GLU   A 1 174 ? 13.71752 -22.39631 -12.46459 1.000 47.50395  ? 708  GLU   A N   1 
ATOM   1238 C  CA  . GLU   A 1 174 ? 15.10936 -22.32736 -12.89721 1.000 40.58604  ? 708  GLU   A CA  1 
ATOM   1239 C  C   . GLU   A 1 174 ? 15.49780 -23.57692 -13.67801 1.000 43.54141  ? 708  GLU   A C   1 
ATOM   1240 O  O   . GLU   A 1 174 ? 16.16951 -23.49537 -14.71248 1.000 40.97224  ? 708  GLU   A O   1 
ATOM   1241 C  CB  . GLU   A 1 174 ? 16.02353 -22.15021 -11.68371 1.000 41.77497  ? 708  GLU   A CB  1 
ATOM   1242 C  CG  . GLU   A 1 174 ? 16.06942 -20.74275 -11.10762 1.000 41.74434  ? 708  GLU   A CG  1 
ATOM   1243 C  CD  . GLU   A 1 174 ? 16.81212 -20.68816 -9.78446  1.000 42.12600  ? 708  GLU   A CD  1 
ATOM   1244 O  OE1 . GLU   A 1 174 ? 16.76338 -21.68839 -9.03654  1.000 44.54026  ? 708  GLU   A OE1 1 
ATOM   1245 O  OE2 . GLU   A 1 174 ? 17.44982 -19.65343 -9.49501  1.000 46.89331  ? 708  GLU   A OE2 1 
ATOM   1246 N  N   . TYR   A 1 175 ? 15.07636 -24.74794 -13.19324 1.000 45.43256  ? 709  TYR   A N   1 
ATOM   1247 C  CA  . TYR   A 1 175 ? 15.43925 -26.00153 -13.84630 1.000 38.76563  ? 709  TYR   A CA  1 
ATOM   1248 C  C   . TYR   A 1 175 ? 14.83455 -26.09732 -15.24096 1.000 41.99723  ? 709  TYR   A C   1 
ATOM   1249 O  O   . TYR   A 1 175 ? 15.49026 -26.56493 -16.17941 1.000 43.01601  ? 709  TYR   A O   1 
ATOM   1250 C  CB  . TYR   A 1 175 ? 14.99360 -27.18235 -12.98479 1.000 35.01625  ? 709  TYR   A CB  1 
ATOM   1251 C  CG  . TYR   A 1 175 ? 15.29675 -28.52968 -13.58446 1.000 38.37532  ? 709  TYR   A CG  1 
ATOM   1252 C  CD1 . TYR   A 1 175 ? 16.60386 -28.97945 -13.70734 1.000 36.11647  ? 709  TYR   A CD1 1 
ATOM   1253 C  CD2 . TYR   A 1 175 ? 14.27409 -29.35583 -14.03089 1.000 40.77447  ? 709  TYR   A CD2 1 
ATOM   1254 C  CE1 . TYR   A 1 175 ? 16.88605 -30.21437 -14.25769 1.000 37.55201  ? 709  TYR   A CE1 1 
ATOM   1255 C  CE2 . TYR   A 1 175 ? 14.54482 -30.59154 -14.58045 1.000 36.61401  ? 709  TYR   A CE2 1 
ATOM   1256 C  CZ  . TYR   A 1 175 ? 15.85156 -31.01702 -14.69350 1.000 42.75433  ? 709  TYR   A CZ  1 
ATOM   1257 O  OH  . TYR   A 1 175 ? 16.12179 -32.25026 -15.24392 1.000 47.09266  ? 709  TYR   A OH  1 
ATOM   1258 N  N   . LYS   A 1 176 ? 13.58609 -25.65347 -15.39929 1.000 45.61699  ? 710  LYS   A N   1 
ATOM   1259 C  CA  . LYS   A 1 176 ? 12.93037 -25.75657 -16.69834 1.000 43.07874  ? 710  LYS   A CA  1 
ATOM   1260 C  C   . LYS   A 1 176 ? 13.51880 -24.76717 -17.69612 1.000 44.36526  ? 710  LYS   A C   1 
ATOM   1261 O  O   . LYS   A 1 176 ? 13.63710 -25.07665 -18.88723 1.000 42.69847  ? 710  LYS   A O   1 
ATOM   1262 C  CB  . LYS   A 1 176 ? 11.42527 -25.54408 -16.54235 1.000 47.55862  ? 710  LYS   A CB  1 
ATOM   1263 C  CG  . LYS   A 1 176 ? 10.66541 -26.82722 -16.24503 1.000 40.25085  ? 710  LYS   A CG  1 
ATOM   1264 C  CD  . LYS   A 1 176 ? 9.16101  -26.62863 -16.31684 1.000 44.10963  ? 710  LYS   A CD  1 
ATOM   1265 C  CE  . LYS   A 1 176 ? 8.66182  -25.72649 -15.20037 1.000 45.46686  ? 710  LYS   A CE  1 
ATOM   1266 N  NZ  . LYS   A 1 176 ? 7.24371  -25.32765 -15.41732 1.000 46.13662  ? 710  LYS   A NZ  1 
ATOM   1267 N  N   . THR   A 1 177 ? 13.88759 -23.57087 -17.23352 1.000 42.78653  ? 711  THR   A N   1 
ATOM   1268 C  CA  . THR   A 1 177 ? 14.55070 -22.61389 -18.11337 1.000 38.31983  ? 711  THR   A CA  1 
ATOM   1269 C  C   . THR   A 1 177 ? 15.91974 -23.13027 -18.53874 1.000 49.67411  ? 711  THR   A C   1 
ATOM   1270 O  O   . THR   A 1 177 ? 16.28849 -23.05536 -19.71675 1.000 45.03863  ? 711  THR   A O   1 
ATOM   1271 C  CB  . THR   A 1 177 ? 14.68205 -21.25756 -17.41706 1.000 43.08480  ? 711  THR   A CB  1 
ATOM   1272 O  OG1 . THR   A 1 177 ? 13.38870 -20.79278 -17.01072 1.000 45.21466  ? 711  THR   A OG1 1 
ATOM   1273 C  CG2 . THR   A 1 177 ? 15.31932 -20.23904 -18.34820 1.000 38.82751  ? 711  THR   A CG2 1 
ATOM   1274 N  N   . THR   A 1 178 ? 16.68341 -23.67382 -17.58666 1.000 46.61456  ? 712  THR   A N   1 
ATOM   1275 C  CA  . THR   A 1 178 ? 18.02111 -24.16865 -17.89630 1.000 34.45166  ? 712  THR   A CA  1 
ATOM   1276 C  C   . THR   A 1 178 ? 17.96633 -25.34114 -18.86684 1.000 39.31404  ? 712  THR   A C   1 
ATOM   1277 O  O   . THR   A 1 178 ? 18.81185 -25.45499 -19.76183 1.000 39.59967  ? 712  THR   A O   1 
ATOM   1278 C  CB  . THR   A 1 178 ? 18.74173 -24.56974 -16.60917 1.000 33.52899  ? 712  THR   A CB  1 
ATOM   1279 O  OG1 . THR   A 1 178 ? 18.69681 -23.47917 -15.68195 1.000 40.21684  ? 712  THR   A OG1 1 
ATOM   1280 C  CG2 . THR   A 1 178 ? 20.20043 -24.90537 -16.89632 1.000 37.97249  ? 712  THR   A CG2 1 
ATOM   1281 N  N   . LEU   A 1 179 ? 16.98021 -26.22668 -18.70290 1.000 42.99644  ? 713  LEU   A N   1 
ATOM   1282 C  CA  . LEU   A 1 179 ? 16.82852 -27.34394 -19.63040 1.000 37.77447  ? 713  LEU   A CA  1 
ATOM   1283 C  C   . LEU   A 1 179 ? 16.53291 -26.85417 -21.04125 1.000 37.29503  ? 713  LEU   A C   1 
ATOM   1284 O  O   . LEU   A 1 179 ? 17.05634 -27.40082 -22.02027 1.000 38.92319  ? 713  LEU   A O   1 
ATOM   1285 C  CB  . LEU   A 1 179 ? 15.71906 -28.28058 -19.15505 1.000 35.65189  ? 713  LEU   A CB  1 
ATOM   1286 C  CG  . LEU   A 1 179 ? 16.14458 -29.53822 -18.39918 1.000 38.79701  ? 713  LEU   A CG  1 
ATOM   1287 C  CD1 . LEU   A 1 179 ? 14.93043 -30.38590 -18.04976 1.000 41.93180  ? 713  LEU   A CD1 1 
ATOM   1288 C  CD2 . LEU   A 1 179 ? 17.14998 -30.34130 -19.21152 1.000 41.98352  ? 713  LEU   A CD2 1 
ATOM   1289 N  N   . LYS   A 1 180 ? 15.68800 -25.82784 -21.16448 1.000 41.48507  ? 714  LYS   A N   1 
ATOM   1290 C  CA  . LYS   A 1 180 ? 15.38897 -25.26957 -22.47827 1.000 38.27586  ? 714  LYS   A CA  1 
ATOM   1291 C  C   . LYS   A 1 180 ? 16.64159 -24.69734 -23.12764 1.000 38.72533  ? 714  LYS   A C   1 
ATOM   1292 O  O   . LYS   A 1 180 ? 16.85421 -24.86111 -24.33472 1.000 39.42738  ? 714  LYS   A O   1 
ATOM   1293 C  CB  . LYS   A 1 180 ? 14.30897 -24.19355 -22.35954 1.000 43.25948  ? 714  LYS   A CB  1 
ATOM   1294 C  CG  . LYS   A 1 180 ? 14.14234 -23.34139 -23.60723 1.000 46.69147  ? 714  LYS   A CG  1 
ATOM   1295 C  CD  . LYS   A 1 180 ? 12.70353 -22.89720 -23.78330 1.000 49.12645  ? 714  LYS   A CD  1 
ATOM   1296 C  CE  . LYS   A 1 180 ? 12.51670 -21.46682 -23.30841 1.000 59.49488  ? 714  LYS   A CE  1 
ATOM   1297 N  NZ  . LYS   A 1 180 ? 13.30628 -20.48809 -24.10794 1.000 57.72435  ? 714  LYS   A NZ  1 
ATOM   1298 N  N   . ILE   A 1 181 ? 17.48809 -24.02891 -22.34038 1.000 40.71948  ? 715  ILE   A N   1 
ATOM   1299 C  CA  . ILE   A 1 181 ? 18.71430 -23.45940 -22.88934 1.000 41.68671  ? 715  ILE   A CA  1 
ATOM   1300 C  C   . ILE   A 1 181 ? 19.70762 -24.56366 -23.23166 1.000 36.48446  ? 715  ILE   A C   1 
ATOM   1301 O  O   . ILE   A 1 181 ? 20.37468 -24.51423 -24.27279 1.000 37.62103  ? 715  ILE   A O   1 
ATOM   1302 C  CB  . ILE   A 1 181 ? 19.31967 -22.43813 -21.90931 1.000 37.67861  ? 715  ILE   A CB  1 
ATOM   1303 C  CG1 . ILE   A 1 181 ? 18.30141 -21.35137 -21.56374 1.000 31.64976  ? 715  ILE   A CG1 1 
ATOM   1304 C  CG2 . ILE   A 1 181 ? 20.56280 -21.80260 -22.51035 1.000 38.42640  ? 715  ILE   A CG2 1 
ATOM   1305 C  CD1 . ILE   A 1 181 ? 18.56064 -20.67145 -20.23107 1.000 33.15518  ? 715  ILE   A CD1 1 
ATOM   1306 N  N   . ILE   A 1 182 ? 19.82398 -25.57462 -22.36382 1.000 35.49535  ? 716  ILE   A N   1 
ATOM   1307 C  CA  . ILE   A 1 182 ? 20.69923 -26.71081 -22.64937 1.000 37.66361  ? 716  ILE   A CA  1 
ATOM   1308 C  C   . ILE   A 1 182 ? 20.27390 -27.38975 -23.94410 1.000 41.16137  ? 716  ILE   A C   1 
ATOM   1309 O  O   . ILE   A 1 182 ? 21.10389 -27.70689 -24.80476 1.000 38.93282  ? 716  ILE   A O   1 
ATOM   1310 C  CB  . ILE   A 1 182 ? 20.69830 -27.70550 -21.47301 1.000 32.59820  ? 716  ILE   A CB  1 
ATOM   1311 C  CG1 . ILE   A 1 182 ? 21.52237 -27.17407 -20.30123 1.000 35.73229  ? 716  ILE   A CG1 1 
ATOM   1312 C  CG2 . ILE   A 1 182 ? 21.23215 -29.05951 -21.91505 1.000 31.77991  ? 716  ILE   A CG2 1 
ATOM   1313 C  CD1 . ILE   A 1 182 ? 21.16678 -27.80871 -18.97039 1.000 30.02525  ? 716  ILE   A CD1 1 
ATOM   1314 N  N   . LYS   A 1 183 ? 18.96747 -27.61406 -24.10109 1.000 41.03658  ? 717  LYS   A N   1 
ATOM   1315 C  CA  . LYS   A 1 183 ? 18.46004 -28.30073 -25.28400 1.000 37.01564  ? 717  LYS   A CA  1 
ATOM   1316 C  C   . LYS   A 1 183 ? 18.75635 -27.50606 -26.54958 1.000 40.67897  ? 717  LYS   A C   1 
ATOM   1317 O  O   . LYS   A 1 183 ? 19.21318 -28.06320 -27.55379 1.000 37.91267  ? 717  LYS   A O   1 
ATOM   1318 C  CB  . LYS   A 1 183 ? 16.95798 -28.54441 -25.13521 1.000 36.08222  ? 717  LYS   A CB  1 
ATOM   1319 C  CG  . LYS   A 1 183 ? 16.31067 -29.22058 -26.33134 1.000 35.72763  ? 717  LYS   A CG  1 
ATOM   1320 C  CD  . LYS   A 1 183 ? 14.89322 -29.65681 -26.00559 1.000 33.57717  ? 717  LYS   A CD  1 
ATOM   1321 C  CE  . LYS   A 1 183 ? 14.30624 -30.51542 -27.11235 1.000 35.72967  ? 717  LYS   A CE  1 
ATOM   1322 N  NZ  . LYS   A 1 183 ? 13.14019 -31.30280 -26.62859 1.000 37.69429  ? 717  LYS   A NZ  1 
ATOM   1323 N  N   . GLN   A 1 184 ? 18.50741 -26.19493 -26.51699 1.000 40.24357  ? 718  GLN   A N   1 
ATOM   1324 C  CA  . GLN   A 1 184 ? 18.76716 -25.36568 -27.68959 1.000 40.54325  ? 718  GLN   A CA  1 
ATOM   1325 C  C   . GLN   A 1 184 ? 20.25234 -25.32472 -28.02416 1.000 41.58762  ? 718  GLN   A C   1 
ATOM   1326 O  O   . GLN   A 1 184 ? 20.62913 -25.34732 -29.20200 1.000 39.45946  ? 718  GLN   A O   1 
ATOM   1327 C  CB  . GLN   A 1 184 ? 18.24141 -23.94990 -27.46255 1.000 44.24791  ? 718  GLN   A CB  1 
ATOM   1328 C  CG  . GLN   A 1 184 ? 16.73369 -23.83314 -27.49141 1.000 47.84129  ? 718  GLN   A CG  1 
ATOM   1329 C  CD  . GLN   A 1 184 ? 16.24921 -22.48827 -26.98962 1.000 58.24430  ? 718  GLN   A CD  1 
ATOM   1330 O  OE1 . GLN   A 1 184 ? 16.90965 -21.84006 -26.17741 1.000 51.99907  ? 718  GLN   A OE1 1 
ATOM   1331 N  NE2 . GLN   A 1 184 ? 15.08797 -22.06220 -27.46994 1.000 65.23191  ? 718  GLN   A NE2 1 
ATOM   1332 N  N   . ALA   A 1 185 ? 21.11036 -25.26254 -27.00215 1.000 42.14699  ? 719  ALA   A N   1 
ATOM   1333 C  CA  . ALA   A 1 185 ? 22.54406 -25.14275 -27.24748 1.000 37.53630  ? 719  ALA   A CA  1 
ATOM   1334 C  C   . ALA   A 1 185 ? 23.10564 -26.40784 -27.88485 1.000 37.60646  ? 719  ALA   A C   1 
ATOM   1335 O  O   . ALA   A 1 185 ? 23.95047 -26.33340 -28.78551 1.000 41.66955  ? 719  ALA   A O   1 
ATOM   1336 C  CB  . ALA   A 1 185 ? 23.27334 -24.82236 -25.94430 1.000 36.15619  ? 719  ALA   A CB  1 
ATOM   1337 N  N   . ILE   A 1 186 ? 22.65114 -27.57844 -27.43262 1.000 36.34394  ? 720  ILE   A N   1 
ATOM   1338 C  CA  . ILE   A 1 186 ? 23.06868 -28.82295 -28.06927 1.000 34.97217  ? 720  ILE   A CA  1 
ATOM   1339 C  C   . ILE   A 1 186 ? 22.47054 -28.93099 -29.46594 1.000 38.52357  ? 720  ILE   A C   1 
ATOM   1340 O  O   . ILE   A 1 186 ? 23.13379 -29.38480 -30.40661 1.000 32.85370  ? 720  ILE   A O   1 
ATOM   1341 C  CB  . ILE   A 1 186 ? 22.68797 -30.02854 -27.19196 1.000 31.03473  ? 720  ILE   A CB  1 
ATOM   1342 C  CG1 . ILE   A 1 186 ? 23.34190 -29.91021 -25.81614 1.000 33.37284  ? 720  ILE   A CG1 1 
ATOM   1343 C  CG2 . ILE   A 1 186 ? 23.08411 -31.33065 -27.87240 1.000 27.63195  ? 720  ILE   A CG2 1 
ATOM   1344 C  CD1 . ILE   A 1 186 ? 23.35847 -31.20364 -25.03249 1.000 26.56121  ? 720  ILE   A CD1 1 
ATOM   1345 N  N   . LEU   A 1 187 ? 21.21077 -28.51378 -29.62594 1.000 41.54229  ? 721  LEU   A N   1 
ATOM   1346 C  CA  . LEU   A 1 187 ? 20.59650 -28.50454 -30.94928 1.000 35.37083  ? 721  LEU   A CA  1 
ATOM   1347 C  C   . LEU   A 1 187 ? 21.32427 -27.55759 -31.89203 1.000 34.18340  ? 721  LEU   A C   1 
ATOM   1348 O  O   . LEU   A 1 187 ? 21.36790 -27.79815 -33.10393 1.000 35.26977  ? 721  LEU   A O   1 
ATOM   1349 C  CB  . LEU   A 1 187 ? 19.12170 -28.11287 -30.83977 1.000 38.29189  ? 721  LEU   A CB  1 
ATOM   1350 C  CG  . LEU   A 1 187 ? 18.13599 -29.18671 -30.37380 1.000 40.35244  ? 721  LEU   A CG  1 
ATOM   1351 C  CD1 . LEU   A 1 187 ? 16.71287 -28.78247 -30.71906 1.000 29.14850  ? 721  LEU   A CD1 1 
ATOM   1352 C  CD2 . LEU   A 1 187 ? 18.47590 -30.54175 -30.97693 1.000 29.87552  ? 721  LEU   A CD2 1 
ATOM   1353 N  N   . ALA   A 1 188 ? 21.91138 -26.48715 -31.35214 1.000 38.51435  ? 722  ALA   A N   1 
ATOM   1354 C  CA  . ALA   A 1 188 ? 22.60405 -25.50415 -32.17375 1.000 32.55216  ? 722  ALA   A CA  1 
ATOM   1355 C  C   . ALA   A 1 188 ? 23.87779 -26.05408 -32.79749 1.000 38.52333  ? 722  ALA   A C   1 
ATOM   1356 O  O   . ALA   A 1 188 ? 24.30868 -25.54752 -33.83866 1.000 46.02180  ? 722  ALA   A O   1 
ATOM   1357 C  CB  . ALA   A 1 188 ? 22.93488 -24.26790 -31.34193 1.000 33.41761  ? 722  ALA   A CB  1 
ATOM   1358 N  N   . THR   A 1 189 ? 24.49029 -27.07008 -32.19094 1.000 34.35878  ? 723  THR   A N   1 
ATOM   1359 C  CA  . THR   A 1 189 ? 25.71329 -27.64402 -32.74637 1.000 33.83911  ? 723  THR   A CA  1 
ATOM   1360 C  C   . THR   A 1 189 ? 25.46825 -28.46073 -34.00816 1.000 36.66578  ? 723  THR   A C   1 
ATOM   1361 O  O   . THR   A 1 189 ? 26.42372 -29.04614 -34.53419 1.000 34.40733  ? 723  THR   A O   1 
ATOM   1362 C  CB  . THR   A 1 189 ? 26.42055 -28.49966 -31.69558 1.000 31.68437  ? 723  THR   A CB  1 
ATOM   1363 O  OG1 . THR   A 1 189 ? 25.63408 -29.66443 -31.40969 1.000 36.33032  ? 723  THR   A OG1 1 
ATOM   1364 C  CG2 . THR   A 1 189 ? 26.63211 -27.69399 -30.41833 1.000 28.93796  ? 723  THR   A CG2 1 
ATOM   1365 N  N   . ASP   A 1 190 ? 24.23029 -28.52568 -34.49470 1.000 38.11250  ? 724  ASP   A N   1 
ATOM   1366 C  CA  . ASP   A 1 190 ? 23.94805 -29.03091 -35.83294 1.000 39.15483  ? 724  ASP   A CA  1 
ATOM   1367 C  C   . ASP   A 1 190 ? 24.34826 -27.94719 -36.82616 1.000 42.45661  ? 724  ASP   A C   1 
ATOM   1368 O  O   . ASP   A 1 190 ? 23.75315 -26.86475 -36.84739 1.000 44.68132  ? 724  ASP   A O   1 
ATOM   1369 C  CB  . ASP   A 1 190 ? 22.47107 -29.39166 -35.96931 1.000 40.20222  ? 724  ASP   A CB  1 
ATOM   1370 C  CG  . ASP   A 1 190 ? 22.14117 -30.05846 -37.29809 1.000 42.36821  ? 724  ASP   A CG  1 
ATOM   1371 O  OD1 . ASP   A 1 190 ? 23.03019 -30.16097 -38.16979 1.000 43.90432  ? 724  ASP   A OD1 1 
ATOM   1372 O  OD2 . ASP   A 1 190 ? 20.97630 -30.47394 -37.47477 1.000 45.09462  ? 724  ASP   A OD2 1 
ATOM   1373 N  N   . LEU   A 1 191 ? 25.36284 -28.23485 -37.64636 1.000 42.59618  ? 725  LEU   A N   1 
ATOM   1374 C  CA  . LEU   A 1 191 ? 25.84457 -27.26316 -38.62359 1.000 42.78388  ? 725  LEU   A CA  1 
ATOM   1375 C  C   . LEU   A 1 191 ? 24.75903 -26.85443 -39.61100 1.000 41.91016  ? 725  LEU   A C   1 
ATOM   1376 O  O   . LEU   A 1 191 ? 24.84317 -25.76878 -40.19762 1.000 45.25426  ? 725  LEU   A O   1 
ATOM   1377 C  CB  . LEU   A 1 191 ? 27.05315 -27.82162 -39.36787 1.000 41.91267  ? 725  LEU   A CB  1 
ATOM   1378 C  CG  . LEU   A 1 191 ? 28.37156 -27.75894 -38.59464 1.000 44.21112  ? 725  LEU   A CG  1 
ATOM   1379 C  CD1 . LEU   A 1 191 ? 29.34100 -28.84527 -39.05181 1.000 44.47993  ? 725  LEU   A CD1 1 
ATOM   1380 C  CD2 . LEU   A 1 191 ? 29.00127 -26.37874 -38.70916 1.000 40.54443  ? 725  LEU   A CD2 1 
ATOM   1381 N  N   . ALA   A 1 192 ? 23.73962 -27.69528 -39.80299 1.000 44.15983  ? 726  ALA   A N   1 
ATOM   1382 C  CA  . ALA   A 1 192 ? 22.59832 -27.29562 -40.61871 1.000 41.92108  ? 726  ALA   A CA  1 
ATOM   1383 C  C   . ALA   A 1 192 ? 21.83179 -26.15474 -39.96302 1.000 41.06006  ? 726  ALA   A C   1 
ATOM   1384 O  O   . ALA   A 1 192 ? 21.43288 -25.19462 -40.63414 1.000 46.79309  ? 726  ALA   A O   1 
ATOM   1385 C  CB  . ALA   A 1 192 ? 21.67735 -28.49036 -40.85537 1.000 35.60694  ? 726  ALA   A CB  1 
ATOM   1386 N  N   . LEU   A 1 193 ? 21.61836 -26.24019 -38.64752 1.000 42.60924  ? 727  LEU   A N   1 
ATOM   1387 C  CA  . LEU   A 1 193 ? 20.95757 -25.14852 -37.93945 1.000 40.21576  ? 727  LEU   A CA  1 
ATOM   1388 C  C   . LEU   A 1 193 ? 21.80593 -23.88374 -37.96808 1.000 45.76949  ? 727  LEU   A C   1 
ATOM   1389 O  O   . LEU   A 1 193 ? 21.27363 -22.76998 -38.04714 1.000 50.47780  ? 727  LEU   A O   1 
ATOM   1390 C  CB  . LEU   A 1 193 ? 20.65497 -25.55653 -36.49709 1.000 41.14278  ? 727  LEU   A CB  1 
ATOM   1391 C  CG  . LEU   A 1 193 ? 19.36656 -26.34196 -36.24108 1.000 41.94265  ? 727  LEU   A CG  1 
ATOM   1392 C  CD1 . LEU   A 1 193 ? 19.01668 -26.31636 -34.75953 1.000 35.83869  ? 727  LEU   A CD1 1 
ATOM   1393 C  CD2 . LEU   A 1 193 ? 18.22112 -25.78588 -37.07026 1.000 47.57048  ? 727  LEU   A CD2 1 
ATOM   1394 N  N   . TYR   A 1 194 ? 23.13044 -24.03715 -37.90354 1.000 49.42057  ? 728  TYR   A N   1 
ATOM   1395 C  CA  . TYR   A 1 194 ? 24.01670 -22.88163 -37.98290 1.000 49.52857  ? 728  TYR   A CA  1 
ATOM   1396 C  C   . TYR   A 1 194 ? 23.89601 -22.18960 -39.33461 1.000 47.73676  ? 728  TYR   A C   1 
ATOM   1397 O  O   . TYR   A 1 194 ? 23.82655 -20.95779 -39.40417 1.000 44.21402  ? 728  TYR   A O   1 
ATOM   1398 C  CB  . TYR   A 1 194 ? 25.45858 -23.31665 -37.72043 1.000 44.52488  ? 728  TYR   A CB  1 
ATOM   1399 C  CG  . TYR   A 1 194 ? 26.50366 -22.35346 -38.23352 1.000 44.69852  ? 728  TYR   A CG  1 
ATOM   1400 C  CD1 . TYR   A 1 194 ? 26.73548 -21.14490 -37.59222 1.000 47.71061  ? 728  TYR   A CD1 1 
ATOM   1401 C  CD2 . TYR   A 1 194 ? 27.26774 -22.65760 -39.35415 1.000 46.69104  ? 728  TYR   A CD2 1 
ATOM   1402 C  CE1 . TYR   A 1 194 ? 27.69306 -20.26068 -38.05454 1.000 46.82324  ? 728  TYR   A CE1 1 
ATOM   1403 C  CE2 . TYR   A 1 194 ? 28.22860 -21.77909 -39.82517 1.000 46.40053  ? 728  TYR   A CE2 1 
ATOM   1404 C  CZ  . TYR   A 1 194 ? 28.43704 -20.58247 -39.17118 1.000 44.69460  ? 728  TYR   A CZ  1 
ATOM   1405 O  OH  . TYR   A 1 194 ? 29.39112 -19.70519 -39.63600 1.000 49.91715  ? 728  TYR   A OH  1 
ATOM   1406 N  N   . ILE   A 1 195 ? 23.85770 -22.96764 -40.41951 1.000 43.56762  ? 729  ILE   A N   1 
ATOM   1407 C  CA  . ILE   A 1 195 ? 23.71609 -22.38812 -41.75233 1.000 52.86132  ? 729  ILE   A CA  1 
ATOM   1408 C  C   . ILE   A 1 195 ? 22.34334 -21.74121 -41.91084 1.000 55.47570  ? 729  ILE   A C   1 
ATOM   1409 O  O   . ILE   A 1 195 ? 22.20580 -20.68968 -42.54861 1.000 55.21305  ? 729  ILE   A O   1 
ATOM   1410 C  CB  . ILE   A 1 195 ? 23.97327 -23.46395 -42.82567 1.000 51.72959  ? 729  ILE   A CB  1 
ATOM   1411 C  CG1 . ILE   A 1 195 ? 25.43489 -23.92438 -42.78512 1.000 40.57871  ? 729  ILE   A CG1 1 
ATOM   1412 C  CG2 . ILE   A 1 195 ? 23.62075 -22.94156 -44.21079 1.000 52.12871  ? 729  ILE   A CG2 1 
ATOM   1413 C  CD1 . ILE   A 1 195 ? 25.68907 -25.24174 -43.49557 1.000 35.79844  ? 729  ILE   A CD1 1 
ATOM   1414 N  N   . LYS   A 1 196 ? 21.31059 -22.34900 -41.32000 1.000 51.97172  ? 730  LYS   A N   1 
ATOM   1415 C  CA  . LYS   A 1 196 ? 19.96568 -21.78376 -41.39090 1.000 52.88526  ? 730  LYS   A CA  1 
ATOM   1416 C  C   . LYS   A 1 196 ? 19.88856 -20.43108 -40.69212 1.000 52.81393  ? 730  LYS   A C   1 
ATOM   1417 O  O   . LYS   A 1 196 ? 19.14959 -19.53975 -41.12764 1.000 57.70276  ? 730  LYS   A O   1 
ATOM   1418 C  CB  . LYS   A 1 196 ? 18.96033 -22.75628 -40.77170 1.000 54.56176  ? 730  LYS   A CB  1 
ATOM   1419 C  CG  . LYS   A 1 196 ? 17.52675 -22.58819 -41.25438 1.000 61.16252  ? 730  LYS   A CG  1 
ATOM   1420 C  CD  . LYS   A 1 196 ? 17.43525 -22.48037 -42.76967 1.000 68.48558  ? 730  LYS   A CD  1 
ATOM   1421 C  CE  . LYS   A 1 196 ? 15.98435 -22.51281 -43.21719 1.000 67.19098  ? 730  LYS   A CE  1 
ATOM   1422 N  NZ  . LYS   A 1 196 ? 15.84652 -22.96239 -44.62439 1.000 65.87738  ? 730  LYS   A NZ  1 
ATOM   1423 N  N   . ARG   A 1 197 ? 20.65949 -20.25210 -39.61684 1.000 53.77441  ? 731  ARG   A N   1 
ATOM   1424 C  CA  . ARG   A 1 197 ? 20.48766 -19.11805 -38.72032 1.000 50.59386  ? 731  ARG   A CA  1 
ATOM   1425 C  C   . ARG   A 1 197 ? 21.58698 -18.06989 -38.80855 1.000 51.07164  ? 731  ARG   A C   1 
ATOM   1426 O  O   . ARG   A 1 197 ? 21.37161 -16.94385 -38.35007 1.000 56.67397  ? 731  ARG   A O   1 
ATOM   1427 C  CB  . ARG   A 1 197 ? 20.39697 -19.60663 -37.26579 1.000 53.87945  ? 731  ARG   A CB  1 
ATOM   1428 C  CG  . ARG   A 1 197 ? 19.14870 -20.41571 -36.95119 1.000 58.70645  ? 731  ARG   A CG  1 
ATOM   1429 C  CD  . ARG   A 1 197 ? 18.65608 -20.14718 -35.54159 1.000 63.78064  ? 731  ARG   A CD  1 
ATOM   1430 N  NE  . ARG   A 1 197 ? 17.78754 -21.21359 -35.05599 1.000 75.90485  ? 731  ARG   A NE  1 
ATOM   1431 C  CZ  . ARG   A 1 197 ? 18.11585 -22.06804 -34.09644 1.000 68.49763  ? 731  ARG   A CZ  1 
ATOM   1432 N  NH1 . ARG   A 1 197 ? 19.29660 -22.01826 -33.50076 1.000 61.38331  ? 731  ARG   A NH1 1 
ATOM   1433 N  NH2 . ARG   A 1 197 ? 17.23595 -22.99256 -33.72214 1.000 69.88381  ? 731  ARG   A NH2 1 
ATOM   1434 N  N   . ARG   A 1 198 ? 22.74451 -18.39861 -39.38882 1.000 50.24604  ? 732  ARG   A N   1 
ATOM   1435 C  CA  . ARG   A 1 198 ? 23.87851 -17.47826 -39.34099 1.000 52.97462  ? 732  ARG   A CA  1 
ATOM   1436 C  C   . ARG   A 1 198 ? 23.61353 -16.21153 -40.14717 1.000 57.66707  ? 732  ARG   A C   1 
ATOM   1437 O  O   . ARG   A 1 198 ? 24.07747 -15.12700 -39.77344 1.000 55.23044  ? 732  ARG   A O   1 
ATOM   1438 C  CB  . ARG   A 1 198 ? 25.14685 -18.17027 -39.83981 1.000 50.73335  ? 732  ARG   A CB  1 
ATOM   1439 C  CG  . ARG   A 1 198 ? 25.04462 -18.72004 -41.25215 1.000 51.85565  ? 732  ARG   A CG  1 
ATOM   1440 C  CD  . ARG   A 1 198 ? 26.40784 -18.79578 -41.91295 1.000 46.93212  ? 732  ARG   A CD  1 
ATOM   1441 N  NE  . ARG   A 1 198 ? 26.38034 -19.58559 -43.13654 1.000 53.19479  ? 732  ARG   A NE  1 
ATOM   1442 C  CZ  . ARG   A 1 198 ? 27.44769 -20.14649 -43.68791 1.000 57.37134  ? 732  ARG   A CZ  1 
ATOM   1443 N  NH1 . ARG   A 1 198 ? 28.64764 -20.03282 -43.14141 1.000 43.28064  ? 732  ARG   A NH1 1 
ATOM   1444 N  NH2 . ARG   A 1 198 ? 27.30804 -20.83726 -44.81704 1.000 58.26198  ? 732  ARG   A NH2 1 
ATOM   1445 N  N   . GLY   A 1 199 ? 22.87709 -16.32703 -41.25584 1.000 56.85150  ? 733  GLY   A N   1 
ATOM   1446 C  CA  . GLY   A 1 199 ? 22.60112 -15.15606 -42.07436 1.000 53.86718  ? 733  GLY   A CA  1 
ATOM   1447 C  C   . GLY   A 1 199 ? 21.85893 -14.07529 -41.31366 1.000 60.27941  ? 733  GLY   A C   1 
ATOM   1448 O  O   . GLY   A 1 199 ? 22.13606 -12.88419 -41.47745 1.000 62.89752  ? 733  GLY   A O   1 
ATOM   1449 N  N   . GLU   A 1 200 ? 20.90324 -14.47724 -40.47358 1.000 61.55224  ? 734  GLU   A N   1 
ATOM   1450 C  CA  . GLU   A 1 200 ? 20.24886 -13.53009 -39.57817 1.000 61.14955  ? 734  GLU   A CA  1 
ATOM   1451 C  C   . GLU   A 1 200 ? 21.26617 -12.86176 -38.66159 1.000 64.20843  ? 734  GLU   A C   1 
ATOM   1452 O  O   . GLU   A 1 200 ? 21.28510 -11.63376 -38.52188 1.000 64.88902  ? 734  GLU   A O   1 
ATOM   1453 C  CB  . GLU   A 1 200 ? 19.17610 -14.25045 -38.75957 1.000 62.97821  ? 734  GLU   A CB  1 
ATOM   1454 C  CG  . GLU   A 1 200 ? 18.50619 -13.38845 -37.70674 1.000 60.16397  ? 734  GLU   A CG  1 
ATOM   1455 C  CD  . GLU   A 1 200 ? 17.22851 -14.00601 -37.17110 1.000 62.50021  ? 734  GLU   A CD  1 
ATOM   1456 O  OE1 . GLU   A 1 200 ? 16.92417 -15.16218 -37.53429 1.000 61.94492  ? 734  GLU   A OE1 1 
ATOM   1457 O  OE2 . GLU   A 1 200 ? 16.53437 -13.34001 -36.37518 1.000 60.06431  ? 734  GLU   A OE2 1 
ATOM   1458 N  N   . PHE   A 1 201 ? 22.13689 -13.66294 -38.04238 1.000 65.48744  ? 735  PHE   A N   1 
ATOM   1459 C  CA  . PHE   A 1 201 ? 23.12251 -13.12537 -37.10899 1.000 62.55508  ? 735  PHE   A CA  1 
ATOM   1460 C  C   . PHE   A 1 201 ? 24.09121 -12.17636 -37.80580 1.000 55.50009  ? 735  PHE   A C   1 
ATOM   1461 O  O   . PHE   A 1 201 ? 24.53106 -11.18299 -37.21493 1.000 58.78940  ? 735  PHE   A O   1 
ATOM   1462 C  CB  . PHE   A 1 201 ? 23.87361 -14.27652 -36.43705 1.000 62.84853  ? 735  PHE   A CB  1 
ATOM   1463 C  CG  . PHE   A 1 201 ? 24.94826 -13.83502 -35.48712 1.000 59.03039  ? 735  PHE   A CG  1 
ATOM   1464 C  CD1 . PHE   A 1 201 ? 24.66696 -12.93987 -34.46900 1.000 56.42748  ? 735  PHE   A CD1 1 
ATOM   1465 C  CD2 . PHE   A 1 201 ? 26.23511 -14.33426 -35.59790 1.000 57.66760  ? 735  PHE   A CD2 1 
ATOM   1466 C  CE1 . PHE   A 1 201 ? 25.65456 -12.53962 -33.58822 1.000 50.71923  ? 735  PHE   A CE1 1 
ATOM   1467 C  CE2 . PHE   A 1 201 ? 27.22420 -13.93950 -34.71867 1.000 53.55884  ? 735  PHE   A CE2 1 
ATOM   1468 C  CZ  . PHE   A 1 201 ? 26.93483 -13.04161 -33.71496 1.000 53.37176  ? 735  PHE   A CZ  1 
ATOM   1469 N  N   . PHE   A 1 202 ? 24.43297 -12.46121 -39.06477 1.000 55.80481  ? 736  PHE   A N   1 
ATOM   1470 C  CA  . PHE   A 1 202 ? 25.33213 -11.57504 -39.79836 1.000 58.30330  ? 736  PHE   A CA  1 
ATOM   1471 C  C   . PHE   A 1 202 ? 24.61559 -10.30701 -40.24543 1.000 65.30812  ? 736  PHE   A C   1 
ATOM   1472 O  O   . PHE   A 1 202 ? 25.20654 -9.22071  -40.24478 1.000 66.04592  ? 736  PHE   A O   1 
ATOM   1473 C  CB  . PHE   A 1 202 ? 25.93000 -12.30250 -41.00280 1.000 57.45491  ? 736  PHE   A CB  1 
ATOM   1474 C  CG  . PHE   A 1 202 ? 26.75452 -13.50624 -40.64088 1.000 55.53603  ? 736  PHE   A CG  1 
ATOM   1475 C  CD1 . PHE   A 1 202 ? 27.40856 -13.57815 -39.42181 1.000 51.93353  ? 736  PHE   A CD1 1 
ATOM   1476 C  CD2 . PHE   A 1 202 ? 26.88017 -14.56393 -41.52577 1.000 49.79192  ? 736  PHE   A CD2 1 
ATOM   1477 C  CE1 . PHE   A 1 202 ? 28.16817 -14.68493 -39.09084 1.000 47.15857  ? 736  PHE   A CE1 1 
ATOM   1478 C  CE2 . PHE   A 1 202 ? 27.63890 -15.67035 -41.20144 1.000 51.22956  ? 736  PHE   A CE2 1 
ATOM   1479 C  CZ  . PHE   A 1 202 ? 28.28242 -15.73321 -39.98293 1.000 48.67224  ? 736  PHE   A CZ  1 
ATOM   1480 N  N   . GLU   A 1 203 ? 23.34480 -10.42684 -40.63728 1.000 67.84033  ? 737  GLU   A N   1 
ATOM   1481 C  CA  . GLU   A 1 203 ? 22.58168 -9.25420  -41.05137 1.000 67.78118  ? 737  GLU   A CA  1 
ATOM   1482 C  C   . GLU   A 1 203 ? 22.42435 -8.26396  -39.90444 1.000 64.30153  ? 737  GLU   A C   1 
ATOM   1483 O  O   . GLU   A 1 203 ? 22.50789 -7.04713  -40.10839 1.000 70.30930  ? 737  GLU   A O   1 
ATOM   1484 C  CB  . GLU   A 1 203 ? 21.21479 -9.68453  -41.58078 1.000 71.96832  ? 737  GLU   A CB  1 
ATOM   1485 C  CG  . GLU   A 1 203 ? 20.49897 -8.61999  -42.38729 1.000 76.62127  ? 737  GLU   A CG  1 
ATOM   1486 C  CD  . GLU   A 1 203 ? 19.05929 -8.98535  -42.67321 1.000 79.49544  ? 737  GLU   A CD  1 
ATOM   1487 O  OE1 . GLU   A 1 203 ? 18.76767 -10.19183 -42.80614 1.000 69.41480  ? 737  GLU   A OE1 1 
ATOM   1488 O  OE2 . GLU   A 1 203 ? 18.21843 -8.06694  -42.75906 1.000 77.99689  ? 737  GLU   A OE2 1 
ATOM   1489 N  N   . LEU   A 1 204 ? 22.19619 -8.76531  -38.68933 1.000 62.00336  ? 738  LEU   A N   1 
ATOM   1490 C  CA  . LEU   A 1 204 ? 22.05355 -7.88934  -37.53378 1.000 66.18328  ? 738  LEU   A CA  1 
ATOM   1491 C  C   . LEU   A 1 204 ? 23.39245 -7.38063  -37.01879 1.000 74.92998  ? 738  LEU   A C   1 
ATOM   1492 O  O   . LEU   A 1 204 ? 23.42830 -6.34653  -36.34287 1.000 77.73015  ? 738  LEU   A O   1 
ATOM   1493 C  CB  . LEU   A 1 204 ? 21.30363 -8.61250  -36.41397 1.000 72.56949  ? 738  LEU   A CB  1 
ATOM   1494 C  CG  . LEU   A 1 204 ? 19.99253 -9.26928  -36.84899 1.000 75.77787  ? 738  LEU   A CG  1 
ATOM   1495 C  CD1 . LEU   A 1 204 ? 19.69207 -10.49379 -35.99710 1.000 67.41339  ? 738  LEU   A CD1 1 
ATOM   1496 C  CD2 . LEU   A 1 204 ? 18.83696 -8.27852  -36.81438 1.000 73.96397  ? 738  LEU   A CD2 1 
ATOM   1497 N  N   . ILE   A 1 205 ? 24.48682 -8.08381  -37.31385 1.000 74.03081  ? 739  ILE   A N   1 
ATOM   1498 C  CA  . ILE   A 1 205 ? 25.81342 -7.55400  -37.01667 1.000 72.21836  ? 739  ILE   A CA  1 
ATOM   1499 C  C   . ILE   A 1 205 ? 26.18136 -6.46303  -38.01495 1.000 71.79653  ? 739  ILE   A C   1 
ATOM   1500 O  O   . ILE   A 1 205 ? 26.83170 -5.47202  -37.66105 1.000 68.00587  ? 739  ILE   A O   1 
ATOM   1501 C  CB  . ILE   A 1 205 ? 26.84828 -8.69698  -37.00046 1.000 69.85001  ? 739  ILE   A CB  1 
ATOM   1502 C  CG1 . ILE   A 1 205 ? 26.83362 -9.40744  -35.64348 1.000 65.94395  ? 739  ILE   A CG1 1 
ATOM   1503 C  CG2 . ILE   A 1 205 ? 28.24667 -8.18626  -37.35983 1.000 70.25118  ? 739  ILE   A CG2 1 
ATOM   1504 C  CD1 . ILE   A 1 205 ? 27.92848 -8.96738  -34.69441 1.000 61.49646  ? 739  ILE   A CD1 1 
ATOM   1505 N  N   . ARG   A 1 206 ? 25.75750 -6.62322  -39.27050 1.000 73.75390  ? 740  ARG   A N   1 
ATOM   1506 C  CA  . ARG   A 1 206 ? 25.98806 -5.60046  -40.28595 1.000 73.80945  ? 740  ARG   A CA  1 
ATOM   1507 C  C   . ARG   A 1 206 ? 25.38843 -4.26299  -39.86809 1.000 79.02671  ? 740  ARG   A C   1 
ATOM   1508 O  O   . ARG   A 1 206 ? 26.10549 -3.27292  -39.68061 1.000 81.87364  ? 740  ARG   A O   1 
ATOM   1509 C  CB  . ARG   A 1 206 ? 25.39414 -6.05088  -41.62198 1.000 68.14490  ? 740  ARG   A CB  1 
ATOM   1510 C  CG  . ARG   A 1 206 ? 26.31250 -6.87923  -42.49802 1.000 67.67717  ? 740  ARG   A CG  1 
ATOM   1511 C  CD  . ARG   A 1 206 ? 25.99235 -6.64587  -43.96359 1.000 72.49266  ? 740  ARG   A CD  1 
ATOM   1512 N  NE  . ARG   A 1 206 ? 24.63658 -7.06511  -44.29877 1.000 73.28001  ? 740  ARG   A NE  1 
ATOM   1513 C  CZ  . ARG   A 1 206 ? 24.29552 -8.30193  -44.63242 1.000 75.17499  ? 740  ARG   A CZ  1 
ATOM   1514 N  NH1 . ARG   A 1 206 ? 25.19284 -9.27220  -44.69967 1.000 66.46939  ? 740  ARG   A NH1 1 
ATOM   1515 N  NH2 . ARG   A 1 206 ? 23.02322 -8.57103  -44.91015 1.000 79.03873  ? 740  ARG   A NH2 1 
ATOM   1516 N  N   . LYS   A 1 207 ? 24.06757 -4.22411  -39.70236 1.000 78.08479  ? 741  LYS   A N   1 
ATOM   1517 C  CA  . LYS   A 1 207 ? 23.26800 -3.01596  -39.49215 1.000 76.63325  ? 741  LYS   A CA  1 
ATOM   1518 C  C   . LYS   A 1 207 ? 23.54060 -2.31906  -38.16518 1.000 77.96459  ? 741  LYS   A C   1 
ATOM   1519 O  O   . LYS   A 1 207 ? 22.78758 -1.38405  -37.85319 1.000 82.79467  ? 741  LYS   A O   1 
ATOM   1520 C  CB  . LYS   A 1 207 ? 21.78064 -3.37005  -39.58415 1.000 73.67319  ? 741  LYS   A CB  1 
ATOM   1521 C  CG  . LYS   A 1 207 ? 21.31049 -3.74769  -40.98144 1.000 73.89150  ? 741  LYS   A CG  1 
ATOM   1522 C  CD  . LYS   A 1 207 ? 20.15771 -4.74211  -40.92247 1.000 73.44855  ? 741  LYS   A CD  1 
ATOM   1523 C  CE  . LYS   A 1 207 ? 19.07196 -4.40081  -41.93069 1.000 72.63778  ? 741  LYS   A CE  1 
ATOM   1524 N  NZ  . LYS   A 1 207 ? 17.73089 -4.29530  -41.29041 1.000 79.06106  ? 741  LYS   A NZ  1 
ATOM   1525 N  N   . ASN   A 1 208 ? 24.54600 -2.71212  -37.38255 1.000 76.09505  ? 742  ASN   A N   1 
ATOM   1526 C  CA  . ASN   A 1 208 ? 24.81557 -2.12870  -36.06947 1.000 81.26916  ? 742  ASN   A CA  1 
ATOM   1527 C  C   . ASN   A 1 208 ? 23.61223 -2.23053  -35.13467 1.000 81.45803  ? 742  ASN   A C   1 
ATOM   1528 O  O   . ASN   A 1 208 ? 23.53134 -1.50286  -34.13908 1.000 77.09712  ? 742  ASN   A O   1 
ATOM   1529 C  CB  . ASN   A 1 208 ? 25.26794 -0.66841  -36.19523 1.000 79.16340  ? 742  ASN   A CB  1 
ATOM   1530 C  CG  . ASN   A 1 208 ? 26.40854 -0.32538  -35.25804 1.000 78.93691  ? 742  ASN   A CG  1 
ATOM   1531 O  OD1 . ASN   A 1 208 ? 27.18486 -1.19185  -34.85573 1.000 79.37928  ? 742  ASN   A OD1 1 
ATOM   1532 N  ND2 . ASN   A 1 208 ? 26.51748 0.95018   -34.90841 1.000 78.32991  ? 742  ASN   A ND2 1 
ATOM   1533 N  N   . GLN   A 1 209 ? 22.68112 -3.13537  -35.43809 1.000 81.32776  ? 743  GLN   A N   1 
ATOM   1534 C  CA  . GLN   A 1 209 ? 21.42830 -3.27213  -34.71184 1.000 82.14944  ? 743  GLN   A CA  1 
ATOM   1535 C  C   . GLN   A 1 209 ? 21.48879 -4.32020  -33.61234 1.000 83.56854  ? 743  GLN   A C   1 
ATOM   1536 O  O   . GLN   A 1 209 ? 20.57173 -4.37661  -32.78459 1.000 80.40920  ? 743  GLN   A O   1 
ATOM   1537 C  CB  . GLN   A 1 209 ? 20.30147 -3.64669  -35.68390 1.000 78.13444  ? 743  GLN   A CB  1 
ATOM   1538 C  CG  . GLN   A 1 209 ? 19.43009 -2.49269  -36.16060 1.000 81.42633  ? 743  GLN   A CG  1 
ATOM   1539 C  CD  . GLN   A 1 209 ? 18.74817 -2.79776  -37.48766 1.000 81.75142  ? 743  GLN   A CD  1 
ATOM   1540 O  OE1 . GLN   A 1 209 ? 18.45162 -3.95025  -37.79906 1.000 80.48678  ? 743  GLN   A OE1 1 
ATOM   1541 N  NE2 . GLN   A 1 209 ? 18.50122 -1.75762  -38.27842 1.000 78.33115  ? 743  GLN   A NE2 1 
ATOM   1542 N  N   . PHE   A 1 210 ? 22.53803 -5.14079  -33.58840 1.000 83.08298  ? 744  PHE   A N   1 
ATOM   1543 C  CA  . PHE   A 1 210 ? 22.58782 -6.29801  -32.70400 1.000 76.47081  ? 744  PHE   A CA  1 
ATOM   1544 C  C   . PHE   A 1 210 ? 22.41008 -5.88156  -31.24972 1.000 72.01914  ? 744  PHE   A C   1 
ATOM   1545 O  O   . PHE   A 1 210 ? 23.20343 -5.10261  -30.71261 1.000 71.09947  ? 744  PHE   A O   1 
ATOM   1546 C  CB  . PHE   A 1 210 ? 23.90897 -7.04044  -32.89299 1.000 74.92588  ? 744  PHE   A CB  1 
ATOM   1547 C  CG  . PHE   A 1 210 ? 24.00836 -8.30095  -32.09197 1.000 76.58179  ? 744  PHE   A CG  1 
ATOM   1548 C  CD1 . PHE   A 1 210 ? 23.36455 -9.45382  -32.51011 1.000 72.55473  ? 744  PHE   A CD1 1 
ATOM   1549 C  CD2 . PHE   A 1 210 ? 24.74446 -8.33602  -30.92237 1.000 72.46855  ? 744  PHE   A CD2 1 
ATOM   1550 C  CE1 . PHE   A 1 210 ? 23.45165 -10.61742 -31.77345 1.000 64.31372  ? 744  PHE   A CE1 1 
ATOM   1551 C  CE2 . PHE   A 1 210 ? 24.83793 -9.49599  -30.18090 1.000 64.42974  ? 744  PHE   A CE2 1 
ATOM   1552 C  CZ  . PHE   A 1 210 ? 24.19072 -10.63975 -30.60764 1.000 55.96621  ? 744  PHE   A CZ  1 
ATOM   1553 N  N   . ASN   A 1 211 ? 21.35940 -6.40221  -30.61969 1.000 71.97643  ? 745  ASN   A N   1 
ATOM   1554 C  CA  . ASN   A 1 211 ? 21.02381 -6.08696  -29.23783 1.000 71.90731  ? 745  ASN   A CA  1 
ATOM   1555 C  C   . ASN   A 1 211 ? 20.73086 -7.38289  -28.50069 1.000 73.56174  ? 745  ASN   A C   1 
ATOM   1556 O  O   . ASN   A 1 211 ? 19.75622 -8.07225  -28.81741 1.000 76.37397  ? 745  ASN   A O   1 
ATOM   1557 C  CB  . ASN   A 1 211 ? 19.82249 -5.14110  -29.16804 1.000 69.98217  ? 745  ASN   A CB  1 
ATOM   1558 C  CG  . ASN   A 1 211 ? 19.26865 -5.00629  -27.76705 1.000 72.61521  ? 745  ASN   A CG  1 
ATOM   1559 O  OD1 . ASN   A 1 211 ? 18.06959 -5.17206  -27.54524 1.000 76.88591  ? 745  ASN   A OD1 1 
ATOM   1560 N  ND2 . ASN   A 1 211 ? 20.13985 -4.70480  -26.81126 1.000 74.58774  ? 745  ASN   A ND2 1 
ATOM   1561 N  N   . LEU   A 1 212 ? 21.57226 -7.71098  -27.51829 1.000 71.90947  ? 746  LEU   A N   1 
ATOM   1562 C  CA  . LEU   A 1 212 ? 21.37165 -8.92837  -26.74225 1.000 65.14322  ? 746  LEU   A CA  1 
ATOM   1563 C  C   . LEU   A 1 212 ? 20.15812 -8.84201  -25.82610 1.000 68.92375  ? 746  LEU   A C   1 
ATOM   1564 O  O   . LEU   A 1 212 ? 19.70427 -9.87637  -25.32610 1.000 71.52175  ? 746  LEU   A O   1 
ATOM   1565 C  CB  . LEU   A 1 212 ? 22.62420 -9.23999  -25.92267 1.000 67.01236  ? 746  LEU   A CB  1 
ATOM   1566 C  CG  . LEU   A 1 212 ? 23.81482 -9.80830  -26.69695 1.000 57.48183  ? 746  LEU   A CG  1 
ATOM   1567 C  CD1 . LEU   A 1 212 ? 25.07151 -9.78714  -25.84311 1.000 51.90560  ? 746  LEU   A CD1 1 
ATOM   1568 C  CD2 . LEU   A 1 212 ? 23.51381 -11.22011 -27.17096 1.000 60.05138  ? 746  LEU   A CD2 1 
ATOM   1569 N  N   . GLU   A 1 213 ? 19.62662 -7.63766  -25.59341 1.000 68.30937  ? 747  GLU   A N   1 
ATOM   1570 C  CA  . GLU   A 1 213 ? 18.43332 -7.50179  -24.76405 1.000 64.23971  ? 747  GLU   A CA  1 
ATOM   1571 C  C   . GLU   A 1 213 ? 17.23315 -8.18831  -25.40003 1.000 64.97016  ? 747  GLU   A C   1 
ATOM   1572 O  O   . GLU   A 1 213 ? 16.35447 -8.68878  -24.68820 1.000 62.53772  ? 747  GLU   A O   1 
ATOM   1573 C  CB  . GLU   A 1 213 ? 18.13329 -6.02423  -24.51196 1.000 66.14876  ? 747  GLU   A CB  1 
ATOM   1574 C  CG  . GLU   A 1 213 ? 18.63551 -5.50175  -23.17465 1.000 74.28190  ? 747  GLU   A CG  1 
ATOM   1575 C  CD  . GLU   A 1 213 ? 17.68479 -4.49927  -22.55076 1.000 84.66166  ? 747  GLU   A CD  1 
ATOM   1576 O  OE1 . GLU   A 1 213 ? 17.57919 -3.37600  -23.08454 1.000 88.34465  ? 747  GLU   A OE1 1 
ATOM   1577 O  OE2 . GLU   A 1 213 ? 17.04253 -4.83079  -21.53138 1.000 78.60314  ? 747  GLU   A OE2 1 
ATOM   1578 N  N   . ASP   A 1 214 ? 17.17837 -8.21870  -26.72472 1.000 64.20341  ? 748  ASP   A N   1 
ATOM   1579 C  CA  . ASP   A 1 214 ? 16.14075 -8.94911  -27.43218 1.000 65.14355  ? 748  ASP   A CA  1 
ATOM   1580 C  C   . ASP   A 1 214 ? 16.29449 -10.43446 -27.12434 1.000 69.92710  ? 748  ASP   A C   1 
ATOM   1581 O  O   . ASP   A 1 214 ? 17.33849 -11.01932 -27.45057 1.000 70.38053  ? 748  ASP   A O   1 
ATOM   1582 C  CB  . ASP   A 1 214 ? 16.24902 -8.68975  -28.93404 1.000 62.45253  ? 748  ASP   A CB  1 
ATOM   1583 C  CG  . ASP   A 1 214 ? 15.11535 -9.31727  -29.72922 1.000 67.53358  ? 748  ASP   A CG  1 
ATOM   1584 O  OD1 . ASP   A 1 214 ? 14.36366 -10.15114 -29.18201 1.000 68.46495  ? 748  ASP   A OD1 1 
ATOM   1585 O  OD2 . ASP   A 1 214 ? 14.97720 -8.96980  -30.92009 1.000 68.78852  ? 748  ASP   A OD2 1 
ATOM   1586 N  N   . PRO   A 1 215 ? 15.30563 -11.07494 -26.49318 1.000 65.94057  ? 749  PRO   A N   1 
ATOM   1587 C  CA  . PRO   A 1 215 ? 15.46080 -12.50557 -26.16971 1.000 61.26115  ? 749  PRO   A CA  1 
ATOM   1588 C  C   . PRO   A 1 215 ? 15.67758 -13.37552 -27.39425 1.000 62.45676  ? 749  PRO   A C   1 
ATOM   1589 O  O   . PRO   A 1 215 ? 16.43710 -14.35059 -27.33092 1.000 66.40291  ? 749  PRO   A O   1 
ATOM   1590 C  CB  . PRO   A 1 215 ? 14.15124 -12.86033 -25.45100 1.000 64.35978  ? 749  PRO   A CB  1 
ATOM   1591 C  CG  . PRO   A 1 215 ? 13.47488 -11.57487 -25.13354 1.000 63.65104  ? 749  PRO   A CG  1 
ATOM   1592 C  CD  . PRO   A 1 215 ? 14.07083 -10.48221 -25.95158 1.000 62.21210  ? 749  PRO   A CD  1 
ATOM   1593 N  N   . HIS   A 1 216 ? 15.01794 -13.05512 -28.51048 1.000 63.38135  ? 750  HIS   A N   1 
ATOM   1594 C  CA  . HIS   A 1 216 ? 15.24989 -13.80072 -29.74261 1.000 63.64478  ? 750  HIS   A CA  1 
ATOM   1595 C  C   . HIS   A 1 216 ? 16.66532 -13.58785 -30.26174 1.000 66.57785  ? 750  HIS   A C   1 
ATOM   1596 O  O   . HIS   A 1 216 ? 17.23924 -14.49079 -30.87966 1.000 62.22488  ? 750  HIS   A O   1 
ATOM   1597 C  CB  . HIS   A 1 216 ? 14.22267 -13.40095 -30.80244 1.000 59.38024  ? 750  HIS   A CB  1 
ATOM   1598 C  CG  . HIS   A 1 216 ? 14.57027 -13.85374 -32.18757 1.000 63.52832  ? 750  HIS   A CG  1 
ATOM   1599 N  ND1 . HIS   A 1 216 ? 14.22945 -15.09887 -32.67096 1.000 63.06929  ? 750  HIS   A ND1 1 
ATOM   1600 C  CD2 . HIS   A 1 216 ? 15.22345 -13.22596 -33.19442 1.000 66.57270  ? 750  HIS   A CD2 1 
ATOM   1601 C  CE1 . HIS   A 1 216 ? 14.66028 -15.21992 -33.91405 1.000 54.93855  ? 750  HIS   A CE1 1 
ATOM   1602 N  NE2 . HIS   A 1 216 ? 15.26704 -14.09751 -34.25569 1.000 62.04562  ? 750  HIS   A NE2 1 
ATOM   1603 N  N   . GLN   A 1 217 ? 17.24277 -12.40903 -30.02069 1.000 67.05645  ? 751  GLN   A N   1 
ATOM   1604 C  CA  . GLN   A 1 217 ? 18.62309 -12.15416 -30.41563 1.000 65.61199  ? 751  GLN   A CA  1 
ATOM   1605 C  C   . GLN   A 1 217 ? 19.61387 -12.79542 -29.45358 1.000 65.60317  ? 751  GLN   A C   1 
ATOM   1606 O  O   . GLN   A 1 217 ? 20.67901 -13.25451 -29.88109 1.000 62.41122  ? 751  GLN   A O   1 
ATOM   1607 C  CB  . GLN   A 1 217 ? 18.87529 -10.64975 -30.49505 1.000 66.95963  ? 751  GLN   A CB  1 
ATOM   1608 C  CG  . GLN   A 1 217 ? 18.42129 -10.00601 -31.79274 1.000 72.73160  ? 751  GLN   A CG  1 
ATOM   1609 C  CD  . GLN   A 1 217 ? 19.41366 -8.98371  -32.30627 1.000 74.37964  ? 751  GLN   A CD  1 
ATOM   1610 O  OE1 . GLN   A 1 217 ? 20.32480 -8.57260  -31.58796 1.000 71.98583  ? 751  GLN   A OE1 1 
ATOM   1611 N  NE2 . GLN   A 1 217 ? 19.21842 -8.53679  -33.53911 1.000 72.78987  ? 751  GLN   A NE2 1 
ATOM   1612 N  N   . LYS   A 1 218 ? 19.28553 -12.82817 -28.15930 1.000 65.14003  ? 752  LYS   A N   1 
ATOM   1613 C  CA  . LYS   A 1 218 ? 20.14006 -13.50901 -27.19221 1.000 59.44497  ? 752  LYS   A CA  1 
ATOM   1614 C  C   . LYS   A 1 218 ? 20.14708 -15.01236 -27.43341 1.000 56.22856  ? 752  LYS   A C   1 
ATOM   1615 O  O   . LYS   A 1 218 ? 21.20577 -15.65007 -27.38661 1.000 56.21034  ? 752  LYS   A O   1 
ATOM   1616 C  CB  . LYS   A 1 218 ? 19.67717 -13.19360 -25.76985 1.000 62.33675  ? 752  LYS   A CB  1 
ATOM   1617 C  CG  . LYS   A 1 218 ? 20.21368 -14.14354 -24.71017 1.000 56.05348  ? 752  LYS   A CG  1 
ATOM   1618 C  CD  . LYS   A 1 218 ? 21.59818 -13.73529 -24.23704 1.000 52.50506  ? 752  LYS   A CD  1 
ATOM   1619 C  CE  . LYS   A 1 218 ? 21.51683 -12.57218 -23.26459 1.000 57.61524  ? 752  LYS   A CE  1 
ATOM   1620 N  NZ  . LYS   A 1 218 ? 20.89922 -12.97618 -21.97173 1.000 53.75231  ? 752  LYS   A NZ  1 
ATOM   1621 N  N   . GLU   A 1 219 ? 18.97529 -15.59178 -27.70783 1.000 54.46099  ? 753  GLU   A N   1 
ATOM   1622 C  CA  . GLU   A 1 219 ? 18.89891 -17.02187 -27.98856 1.000 51.67034  ? 753  GLU   A CA  1 
ATOM   1623 C  C   . GLU   A 1 219 ? 19.66488 -17.37546 -29.25677 1.000 54.48177  ? 753  GLU   A C   1 
ATOM   1624 O  O   . GLU   A 1 219 ? 20.31209 -18.42699 -29.32948 1.000 52.69029  ? 753  GLU   A O   1 
ATOM   1625 C  CB  . GLU   A 1 219 ? 17.43645 -17.45045 -28.10564 1.000 55.45981  ? 753  GLU   A CB  1 
ATOM   1626 C  CG  . GLU   A 1 219 ? 17.23788 -18.93435 -28.34797 1.000 57.86845  ? 753  GLU   A CG  1 
ATOM   1627 C  CD  . GLU   A 1 219 ? 15.89840 -19.24232 -28.98248 1.000 67.06895  ? 753  GLU   A CD  1 
ATOM   1628 O  OE1 . GLU   A 1 219 ? 14.99251 -18.38541 -28.90680 1.000 71.46682  ? 753  GLU   A OE1 1 
ATOM   1629 O  OE2 . GLU   A 1 219 ? 15.75106 -20.33988 -29.55841 1.000 66.46307  ? 753  GLU   A OE2 1 
ATOM   1630 N  N   . LEU   A 1 220 ? 19.60242 -16.50731 -30.26847 1.000 55.47318  ? 754  LEU   A N   1 
ATOM   1631 C  CA  . LEU   A 1 220 ? 20.36487 -16.74038 -31.48972 1.000 49.57057  ? 754  LEU   A CA  1 
ATOM   1632 C  C   . LEU   A 1 220 ? 21.86351 -16.66614 -31.22613 1.000 52.41178  ? 754  LEU   A C   1 
ATOM   1633 O  O   . LEU   A 1 220 ? 22.63539 -17.46993 -31.76248 1.000 46.50756  ? 754  LEU   A O   1 
ATOM   1634 C  CB  . LEU   A 1 220 ? 19.95712 -15.73073 -32.56135 1.000 51.67761  ? 754  LEU   A CB  1 
ATOM   1635 C  CG  . LEU   A 1 220 ? 20.81532 -15.70910 -33.82681 1.000 53.68086  ? 754  LEU   A CG  1 
ATOM   1636 C  CD1 . LEU   A 1 220 ? 20.41997 -16.83485 -34.77475 1.000 50.71050  ? 754  LEU   A CD1 1 
ATOM   1637 C  CD2 . LEU   A 1 220 ? 20.70470 -14.35852 -34.50903 1.000 56.68001  ? 754  LEU   A CD2 1 
ATOM   1638 N  N   . PHE   A 1 221 ? 22.29255 -15.71254 -30.39352 1.000 52.89748  ? 755  PHE   A N   1 
ATOM   1639 C  CA  . PHE   A 1 221 ? 23.71580 -15.56484 -30.10269 1.000 51.39054  ? 755  PHE   A CA  1 
ATOM   1640 C  C   . PHE   A 1 221 ? 24.26128 -16.78036 -29.36390 1.000 52.08869  ? 755  PHE   A C   1 
ATOM   1641 O  O   . PHE   A 1 221 ? 25.38561 -17.22293 -29.62877 1.000 51.76477  ? 755  PHE   A O   1 
ATOM   1642 C  CB  . PHE   A 1 221 ? 23.95879 -14.29659 -29.28547 1.000 50.84959  ? 755  PHE   A CB  1 
ATOM   1643 C  CG  . PHE   A 1 221 ? 25.35893 -14.18028 -28.75336 1.000 48.11510  ? 755  PHE   A CG  1 
ATOM   1644 C  CD1 . PHE   A 1 221 ? 26.42781 -13.99997 -29.61428 1.000 48.09453  ? 755  PHE   A CD1 1 
ATOM   1645 C  CD2 . PHE   A 1 221 ? 25.60705 -14.26065 -27.39228 1.000 51.06828  ? 755  PHE   A CD2 1 
ATOM   1646 C  CE1 . PHE   A 1 221 ? 27.71792 -13.89649 -29.12989 1.000 47.07287  ? 755  PHE   A CE1 1 
ATOM   1647 C  CE2 . PHE   A 1 221 ? 26.89547 -14.15794 -26.90098 1.000 50.22015  ? 755  PHE   A CE2 1 
ATOM   1648 C  CZ  . PHE   A 1 221 ? 27.95217 -13.97542 -27.77165 1.000 49.40698  ? 755  PHE   A CZ  1 
ATOM   1649 N  N   . LEU   A 1 222 ? 23.48426 -17.32626 -28.42318 1.000 48.63925  ? 756  LEU   A N   1 
ATOM   1650 C  CA  . LEU   A 1 222 ? 23.91770 -18.52336 -27.70899 1.000 44.88428  ? 756  LEU   A CA  1 
ATOM   1651 C  C   . LEU   A 1 222 ? 24.11607 -19.68668 -28.66877 1.000 43.52124  ? 756  LEU   A C   1 
ATOM   1652 O  O   . LEU   A 1 222 ? 25.00002 -20.52786 -28.46724 1.000 47.25510  ? 756  LEU   A O   1 
ATOM   1653 C  CB  . LEU   A 1 222 ? 22.89991 -18.89045 -26.63012 1.000 43.44485  ? 756  LEU   A CB  1 
ATOM   1654 C  CG  . LEU   A 1 222 ? 22.76472 -17.90029 -25.47436 1.000 48.37161  ? 756  LEU   A CG  1 
ATOM   1655 C  CD1 . LEU   A 1 222 ? 21.68372 -18.34708 -24.50154 1.000 39.66548  ? 756  LEU   A CD1 1 
ATOM   1656 C  CD2 . LEU   A 1 222 ? 24.09746 -17.73852 -24.76780 1.000 48.65286  ? 756  LEU   A CD2 1 
ATOM   1657 N  N   . ALA   A 1 223 ? 23.29696 -19.74947 -29.72012 1.000 46.01006  ? 757  ALA   A N   1 
ATOM   1658 C  CA  . ALA   A 1 223 ? 23.47237 -20.77572 -30.73979 1.000 43.93729  ? 757  ALA   A CA  1 
ATOM   1659 C  C   . ALA   A 1 223 ? 24.77318 -20.57374 -31.50423 1.000 43.04847  ? 757  ALA   A C   1 
ATOM   1660 O  O   . ALA   A 1 223 ? 25.48007 -21.54244 -31.80529 1.000 40.90750  ? 757  ALA   A O   1 
ATOM   1661 C  CB  . ALA   A 1 223 ? 22.28050 -20.77054 -31.69603 1.000 43.55921  ? 757  ALA   A CB  1 
ATOM   1662 N  N   . MET   A 1 224 ? 25.10684 -19.32115 -31.82388 1.000 46.73742  ? 758  MET   A N   1 
ATOM   1663 C  CA  . MET   A 1 224 ? 26.34741 -19.04790 -32.54134 1.000 39.70582  ? 758  MET   A CA  1 
ATOM   1664 C  C   . MET   A 1 224 ? 27.56287 -19.27104 -31.64952 1.000 41.02555  ? 758  MET   A C   1 
ATOM   1665 O  O   . MET   A 1 224 ? 28.60972 -19.72898 -32.12230 1.000 40.84922  ? 758  MET   A O   1 
ATOM   1666 C  CB  . MET   A 1 224 ? 26.33440 -17.62035 -33.08767 1.000 47.65000  ? 758  MET   A CB  1 
ATOM   1667 C  CG  . MET   A 1 224 ? 25.06695 -17.24896 -33.84603 1.000 44.32903  ? 758  MET   A CG  1 
ATOM   1668 S  SD  . MET   A 1 224 ? 25.10879 -17.75448 -35.57724 1.000 51.16204  ? 758  MET   A SD  1 
ATOM   1669 C  CE  . MET   A 1 224 ? 24.25174 -19.32806 -35.51295 1.000 45.17417  ? 758  MET   A CE  1 
ATOM   1670 N  N   . LEU   A 1 225 ? 27.44592 -18.95012 -30.35822 1.000 40.37729  ? 759  LEU   A N   1 
ATOM   1671 C  CA  . LEU   A 1 225 ? 28.55073 -19.18781 -29.43460 1.000 35.75519  ? 759  LEU   A CA  1 
ATOM   1672 C  C   . LEU   A 1 225 ? 28.85200 -20.67634 -29.31077 1.000 39.05085  ? 759  LEU   A C   1 
ATOM   1673 O  O   . LEU   A 1 225 ? 30.01180 -21.07163 -29.14028 1.000 43.67270  ? 759  LEU   A O   1 
ATOM   1674 C  CB  . LEU   A 1 225 ? 28.22425 -18.58932 -28.06715 1.000 33.22238  ? 759  LEU   A CB  1 
ATOM   1675 C  CG  . LEU   A 1 225 ? 29.33842 -18.58754 -27.02086 1.000 30.51292  ? 759  LEU   A CG  1 
ATOM   1676 C  CD1 . LEU   A 1 225 ? 30.60217 -17.93982 -27.56906 1.000 31.24060  ? 759  LEU   A CD1 1 
ATOM   1677 C  CD2 . LEU   A 1 225 ? 28.86670 -17.87913 -25.76654 1.000 33.05013  ? 759  LEU   A CD2 1 
ATOM   1678 N  N   . MET   A 1 226 ? 27.81780 -21.51681 -29.40142 1.000 37.43558  ? 760  MET   A N   1 
ATOM   1679 C  CA  . MET   A 1 226 ? 28.01685 -22.96110 -29.33220 1.000 34.96732  ? 760  MET   A CA  1 
ATOM   1680 C  C   . MET   A 1 226 ? 28.84954 -23.45509 -30.50736 1.000 37.83413  ? 760  MET   A C   1 
ATOM   1681 O  O   . MET   A 1 226 ? 29.84214 -24.16913 -30.32344 1.000 40.01653  ? 760  MET   A O   1 
ATOM   1682 C  CB  . MET   A 1 226 ? 26.66368 -23.67210 -29.29570 1.000 38.78218  ? 760  MET   A CB  1 
ATOM   1683 C  CG  . MET   A 1 226 ? 25.96111 -23.60148 -27.95128 1.000 36.95456  ? 760  MET   A CG  1 
ATOM   1684 S  SD  . MET   A 1 226 ? 26.98302 -24.20800 -26.59530 1.000 41.69818  ? 760  MET   A SD  1 
ATOM   1685 C  CE  . MET   A 1 226 ? 26.95727 -25.97191 -26.90827 1.000 26.22401  ? 760  MET   A CE  1 
ATOM   1686 N  N   . THR   A 1 227 ? 28.45649 -23.07977 -31.72823 1.000 38.12415  ? 761  THR   A N   1 
ATOM   1687 C  CA  . THR   A 1 227 ? 29.18550 -23.51561 -32.91517 1.000 35.76968  ? 761  THR   A CA  1 
ATOM   1688 C  C   . THR   A 1 227 ? 30.61915 -22.99697 -32.89869 1.000 34.76774  ? 761  THR   A C   1 
ATOM   1689 O  O   . THR   A 1 227 ? 31.54439 -23.68818 -33.34203 1.000 36.65524  ? 761  THR   A O   1 
ATOM   1690 C  CB  . THR   A 1 227 ? 28.45228 -23.04775 -34.17529 1.000 38.98575  ? 761  THR   A CB  1 
ATOM   1691 O  OG1 . THR   A 1 227 ? 27.17948 -23.70441 -34.26528 1.000 41.31493  ? 761  THR   A OG1 1 
ATOM   1692 C  CG2 . THR   A 1 227 ? 29.25983 -23.36916 -35.42230 1.000 34.90713  ? 761  THR   A CG2 1 
ATOM   1693 N  N   . ALA   A 1 228 ? 30.82489 -21.78769 -32.37118 1.000 40.26455  ? 762  ALA   A N   1 
ATOM   1694 C  CA  . ALA   A 1 228 ? 32.17166 -21.23094 -32.29012 1.000 35.45786  ? 762  ALA   A CA  1 
ATOM   1695 C  C   . ALA   A 1 228 ? 33.07087 -22.10108 -31.42196 1.000 35.84037  ? 762  ALA   A C   1 
ATOM   1696 O  O   . ALA   A 1 228 ? 34.20103 -22.42682 -31.80468 1.000 33.91329  ? 762  ALA   A O   1 
ATOM   1697 C  CB  . ALA   A 1 228 ? 32.11400 -19.80207 -31.75180 1.000 34.11159  ? 762  ALA   A CB  1 
ATOM   1698 N  N   . CYS   A 1 229 ? 32.57858 -22.49697 -30.24727 1.000 38.72671  ? 763  CYS   A N   1 
ATOM   1699 C  CA  . CYS   A 1 229 ? 33.34755 -23.39523 -29.39444 1.000 38.23079  ? 763  CYS   A CA  1 
ATOM   1700 C  C   . CYS   A 1 229 ? 33.39670 -24.80182 -29.97725 1.000 34.02543  ? 763  CYS   A C   1 
ATOM   1701 O  O   . CYS   A 1 229 ? 34.38853 -25.51724 -29.79081 1.000 36.38871  ? 763  CYS   A O   1 
ATOM   1702 C  CB  . CYS   A 1 229 ? 32.74277 -23.42293 -27.98959 1.000 32.75838  ? 763  CYS   A CB  1 
ATOM   1703 S  SG  . CYS   A 1 229 ? 32.72027 -21.81501 -27.14982 1.000 37.67638  ? 763  CYS   A SG  1 
ATOM   1704 N  N   . ASP   A 1 230 ? 32.33824 -25.20595 -30.68840 1.000 34.07676  ? 764  ASP   A N   1 
ATOM   1705 C  CA  . ASP   A 1 230 ? 32.28091 -26.54286 -31.27191 1.000 33.98428  ? 764  ASP   A CA  1 
ATOM   1706 C  C   . ASP   A 1 230 ? 33.37640 -26.75014 -32.30916 1.000 37.81369  ? 764  ASP   A C   1 
ATOM   1707 O  O   . ASP   A 1 230 ? 33.90403 -27.86195 -32.44331 1.000 35.68034  ? 764  ASP   A O   1 
ATOM   1708 C  CB  . ASP   A 1 230 ? 30.90412 -26.78180 -31.89702 1.000 34.29941  ? 764  ASP   A CB  1 
ATOM   1709 C  CG  . ASP   A 1 230 ? 30.69525 -28.22601 -32.32140 1.000 32.97370  ? 764  ASP   A CG  1 
ATOM   1710 O  OD1 . ASP   A 1 230 ? 31.13926 -29.13123 -31.58765 1.000 35.11561  ? 764  ASP   A OD1 1 
ATOM   1711 O  OD2 . ASP   A 1 230 ? 30.07812 -28.45786 -33.38373 1.000 44.42044  ? 764  ASP   A OD2 1 
ATOM   1712 N  N   . LEU   A 1 231 ? 33.73907 -25.69510 -33.04134 1.000 33.38560  ? 765  LEU   A N   1 
ATOM   1713 C  CA  . LEU   A 1 231 ? 34.78447 -25.75838 -34.05510 1.000 37.23536  ? 765  LEU   A CA  1 
ATOM   1714 C  C   . LEU   A 1 231 ? 36.06448 -25.06399 -33.60724 1.000 40.81110  ? 765  LEU   A C   1 
ATOM   1715 O  O   . LEU   A 1 231 ? 36.88289 -24.68075 -34.44948 1.000 39.06765  ? 765  LEU   A O   1 
ATOM   1716 C  CB  . LEU   A 1 231 ? 34.30073 -25.13933 -35.36672 1.000 28.93090  ? 765  LEU   A CB  1 
ATOM   1717 C  CG  . LEU   A 1 231 ? 32.86189 -25.41953 -35.79616 1.000 36.32060  ? 765  LEU   A CG  1 
ATOM   1718 C  CD1 . LEU   A 1 231 ? 32.45715 -24.52284 -36.95767 1.000 41.32236  ? 765  LEU   A CD1 1 
ATOM   1719 C  CD2 . LEU   A 1 231 ? 32.68714 -26.88259 -36.16004 1.000 31.73703  ? 765  LEU   A CD2 1 
ATOM   1720 N  N   . SER   A 1 232 ? 36.25401 -24.89508 -32.29635 1.000 38.30175  ? 766  SER   A N   1 
ATOM   1721 C  CA  . SER   A 1 232 ? 37.39432 -24.14142 -31.78482 1.000 36.86558  ? 766  SER   A CA  1 
ATOM   1722 C  C   . SER   A 1 232 ? 38.73048 -24.74564 -32.19160 1.000 32.17083  ? 766  SER   A C   1 
ATOM   1723 O  O   . SER   A 1 232 ? 39.75658 -24.05937 -32.12041 1.000 33.31775  ? 766  SER   A O   1 
ATOM   1724 C  CB  . SER   A 1 232 ? 37.31585 -24.05936 -30.26281 1.000 40.77354  ? 766  SER   A CB  1 
ATOM   1725 O  OG  . SER   A 1 232 ? 37.61866 -25.31586 -29.68105 1.000 38.46936  ? 766  SER   A OG  1 
ATOM   1726 N  N   . ALA   A 1 233 ? 38.74127 -26.01146 -32.61176 1.000 31.44843  ? 767  ALA   A N   1 
ATOM   1727 C  CA  . ALA   A 1 233 ? 39.99054 -26.65159 -33.00692 1.000 33.54652  ? 767  ALA   A CA  1 
ATOM   1728 C  C   . ALA   A 1 233 ? 40.60874 -25.96522 -34.21656 1.000 33.64535  ? 767  ALA   A C   1 
ATOM   1729 O  O   . ALA   A 1 233 ? 41.83585 -25.87217 -34.32741 1.000 37.26992  ? 767  ALA   A O   1 
ATOM   1730 C  CB  . ALA   A 1 233 ? 39.74645 -28.13012 -33.29215 1.000 32.56966  ? 767  ALA   A CB  1 
ATOM   1731 N  N   . ILE   A 1 234 ? 39.77327 -25.46212 -35.12783 1.000 34.00483  ? 768  ILE   A N   1 
ATOM   1732 C  CA  . ILE   A 1 234 ? 40.26819 -24.79446 -36.32766 1.000 38.97803  ? 768  ILE   A CA  1 
ATOM   1733 C  C   . ILE   A 1 234 ? 40.97580 -23.48300 -36.02084 1.000 36.83073  ? 768  ILE   A C   1 
ATOM   1734 O  O   . ILE   A 1 234 ? 41.56834 -22.88053 -36.92394 1.000 36.68263  ? 768  ILE   A O   1 
ATOM   1735 C  CB  . ILE   A 1 234 ? 39.11199 -24.55839 -37.32431 1.000 31.76252  ? 768  ILE   A CB  1 
ATOM   1736 C  CG1 . ILE   A 1 234 ? 39.63726 -24.44309 -38.75677 1.000 31.35233  ? 768  ILE   A CG1 1 
ATOM   1737 C  CG2 . ILE   A 1 234 ? 38.32518 -23.31185 -36.94496 1.000 33.99807  ? 768  ILE   A CG2 1 
ATOM   1738 C  CD1 . ILE   A 1 234 ? 40.21750 -25.73024 -39.29885 1.000 34.20009  ? 768  ILE   A CD1 1 
ATOM   1739 N  N   . THR   A 1 235 ? 40.94581 -23.03535 -34.76704 1.000 33.89648  ? 769  THR   A N   1 
ATOM   1740 C  CA  . THR   A 1 235 ? 41.61419 -21.81248 -34.34974 1.000 35.70645  ? 769  THR   A CA  1 
ATOM   1741 C  C   . THR   A 1 235 ? 42.86727 -22.07207 -33.52566 1.000 36.80847  ? 769  THR   A C   1 
ATOM   1742 O  O   . THR   A 1 235 ? 43.54252 -21.11414 -33.13314 1.000 36.17945  ? 769  THR   A O   1 
ATOM   1743 C  CB  . THR   A 1 235 ? 40.65298 -20.93276 -33.54123 1.000 34.23536  ? 769  THR   A CB  1 
ATOM   1744 O  OG1 . THR   A 1 235 ? 40.44796 -21.51578 -32.24984 1.000 33.22562  ? 769  THR   A OG1 1 
ATOM   1745 C  CG2 . THR   A 1 235 ? 39.31436 -20.81997 -34.24181 1.000 35.37333  ? 769  THR   A CG2 1 
ATOM   1746 N  N   . LYS   A 1 236 ? 43.19533 -23.33391 -33.25513 1.000 37.11547  ? 770  LYS   A N   1 
ATOM   1747 C  CA  . LYS   A 1 236 ? 44.31751 -23.66696 -32.39452 1.000 40.86369  ? 770  LYS   A CA  1 
ATOM   1748 C  C   . LYS   A 1 236 ? 45.64245 -23.37200 -33.09680 1.000 40.69271  ? 770  LYS   A C   1 
ATOM   1749 O  O   . LYS   A 1 236 ? 45.68592 -23.20748 -34.31923 1.000 43.01523  ? 770  LYS   A O   1 
ATOM   1750 C  CB  . LYS   A 1 236 ? 44.23958 -25.13854 -31.99408 1.000 37.96288  ? 770  LYS   A CB  1 
ATOM   1751 C  CG  . LYS   A 1 236 ? 43.06067 -25.46219 -31.09010 1.000 35.33028  ? 770  LYS   A CG  1 
ATOM   1752 C  CD  . LYS   A 1 236 ? 43.11589 -24.65865 -29.80068 1.000 33.66458  ? 770  LYS   A CD  1 
ATOM   1753 C  CE  . LYS   A 1 236 ? 42.13641 -25.19840 -28.77015 1.000 35.85309  ? 770  LYS   A CE  1 
ATOM   1754 N  NZ  . LYS   A 1 236 ? 42.11834 -24.36895 -27.53370 1.000 37.00839  ? 770  LYS   A NZ  1 
ATOM   1755 N  N   . PRO   A 1 237 ? 46.73711 -23.27743 -32.33964 1.000 39.11845  ? 771  PRO   A N   1 
ATOM   1756 C  CA  . PRO   A 1 237 ? 48.04882 -23.09320 -32.97192 1.000 34.76713  ? 771  PRO   A CA  1 
ATOM   1757 C  C   . PRO   A 1 237 ? 48.37747 -24.23097 -33.92901 1.000 38.90962  ? 771  PRO   A C   1 
ATOM   1758 O  O   . PRO   A 1 237 ? 47.93146 -25.36791 -33.75650 1.000 37.64935  ? 771  PRO   A O   1 
ATOM   1759 C  CB  . PRO   A 1 237 ? 49.01453 -23.06000 -31.78226 1.000 32.19907  ? 771  PRO   A CB  1 
ATOM   1760 C  CG  . PRO   A 1 237 ? 48.17513 -22.58144 -30.64543 1.000 38.07182  ? 771  PRO   A CG  1 
ATOM   1761 C  CD  . PRO   A 1 237 ? 46.81671 -23.17330 -30.87146 1.000 38.21323  ? 771  PRO   A CD  1 
ATOM   1762 N  N   . TRP   A 1 238 ? 49.17360 -23.89999 -34.94787 1.000 43.32557  ? 772  TRP   A N   1 
ATOM   1763 C  CA  . TRP   A 1 238 ? 49.44245 -24.80625 -36.06601 1.000 37.93553  ? 772  TRP   A CA  1 
ATOM   1764 C  C   . TRP   A 1 238 ? 49.86800 -26.21075 -35.64816 1.000 39.18580  ? 772  TRP   A C   1 
ATOM   1765 O  O   . TRP   A 1 238 ? 49.30063 -27.17942 -36.17896 1.000 38.61984  ? 772  TRP   A O   1 
ATOM   1766 C  CB  . TRP   A 1 238 ? 50.48943 -24.15903 -36.98526 1.000 40.21489  ? 772  TRP   A CB  1 
ATOM   1767 C  CG  . TRP   A 1 238 ? 50.86243 -24.97867 -38.18808 1.000 42.21180  ? 772  TRP   A CG  1 
ATOM   1768 C  CD1 . TRP   A 1 238 ? 52.12499 -25.31228 -38.58295 1.000 40.41518  ? 772  TRP   A CD1 1 
ATOM   1769 C  CD2 . TRP   A 1 238 ? 49.97475 -25.55803 -39.15850 1.000 41.93133  ? 772  TRP   A CD2 1 
ATOM   1770 N  NE1 . TRP   A 1 238 ? 52.08188 -26.06423 -39.72952 1.000 41.80699  ? 772  TRP   A NE1 1 
ATOM   1771 C  CE2 . TRP   A 1 238 ? 50.77518 -26.22956 -40.10470 1.000 44.04133  ? 772  TRP   A CE2 1 
ATOM   1772 C  CE3 . TRP   A 1 238 ? 48.58393 -25.57712 -39.31873 1.000 41.72790  ? 772  TRP   A CE3 1 
ATOM   1773 C  CZ2 . TRP   A 1 238 ? 50.23374 -26.91122 -41.19429 1.000 41.60552  ? 772  TRP   A CZ2 1 
ATOM   1774 C  CZ3 . TRP   A 1 238 ? 48.04829 -26.25907 -40.40378 1.000 40.32910  ? 772  TRP   A CZ3 1 
ATOM   1775 C  CH2 . TRP   A 1 238 ? 48.87256 -26.91521 -41.32511 1.000 41.46168  ? 772  TRP   A CH2 1 
ATOM   1776 N  N   . PRO   A 1 239 ? 50.83129 -26.40699 -34.73684 1.000 44.76480  ? 773  PRO   A N   1 
ATOM   1777 C  CA  . PRO   A 1 239 ? 51.16484 -27.78537 -34.33440 1.000 39.99144  ? 773  PRO   A CA  1 
ATOM   1778 C  C   . PRO   A 1 239 ? 50.00677 -28.51428 -33.67892 1.000 39.07205  ? 773  PRO   A C   1 
ATOM   1779 O  O   . PRO   A 1 239 ? 49.89713 -29.73820 -33.81835 1.000 43.80284  ? 773  PRO   A O   1 
ATOM   1780 C  CB  . PRO   A 1 239 ? 52.33658 -27.59163 -33.36041 1.000 38.27965  ? 773  PRO   A CB  1 
ATOM   1781 C  CG  . PRO   A 1 239 ? 52.88877 -26.24749 -33.68590 1.000 37.96990  ? 773  PRO   A CG  1 
ATOM   1782 C  CD  . PRO   A 1 239 ? 51.69405 -25.42889 -34.04841 1.000 38.34780  ? 773  PRO   A CD  1 
ATOM   1783 N  N   . ILE   A 1 240 ? 49.13716 -27.79973 -32.96469 1.000 35.71511  ? 774  ILE   A N   1 
ATOM   1784 C  CA  . ILE   A 1 240 ? 47.95927 -28.43490 -32.38367 1.000 39.14636  ? 774  ILE   A CA  1 
ATOM   1785 C  C   . ILE   A 1 240 ? 46.91524 -28.69798 -33.46244 1.000 38.61520  ? 774  ILE   A C   1 
ATOM   1786 O  O   . ILE   A 1 240 ? 46.33889 -29.78965 -33.54109 1.000 39.15492  ? 774  ILE   A O   1 
ATOM   1787 C  CB  . ILE   A 1 240 ? 47.38973 -27.56769 -31.24741 1.000 39.01877  ? 774  ILE   A CB  1 
ATOM   1788 C  CG1 . ILE   A 1 240 ? 48.52560 -27.01677 -30.37933 1.000 37.87592  ? 774  ILE   A CG1 1 
ATOM   1789 C  CG2 . ILE   A 1 240 ? 46.37997 -28.35830 -30.42458 1.000 41.41875  ? 774  ILE   A CG2 1 
ATOM   1790 C  CD1 . ILE   A 1 240 ? 49.02131 -27.97884 -29.32459 1.000 37.03091  ? 774  ILE   A CD1 1 
ATOM   1791 N  N   . GLN   A 1 241 ? 46.66008 -27.69769 -34.31183 1.000 38.25907  ? 775  GLN   A N   1 
ATOM   1792 C  CA  . GLN   A 1 241 ? 45.67674 -27.84920 -35.38135 1.000 39.05203  ? 775  GLN   A CA  1 
ATOM   1793 C  C   . GLN   A 1 241 ? 46.05101 -28.99027 -36.31953 1.000 38.39005  ? 775  GLN   A C   1 
ATOM   1794 O  O   . GLN   A 1 241 ? 45.17846 -29.73199 -36.78747 1.000 42.31401  ? 775  GLN   A O   1 
ATOM   1795 C  CB  . GLN   A 1 241 ? 45.54514 -26.53340 -36.15064 1.000 37.23698  ? 775  GLN   A CB  1 
ATOM   1796 C  CG  . GLN   A 1 241 ? 45.04356 -26.66898 -37.57998 1.000 36.31461  ? 775  GLN   A CG  1 
ATOM   1797 C  CD  . GLN   A 1 241 ? 43.64518 -27.24764 -37.66043 1.000 39.97329  ? 775  GLN   A CD  1 
ATOM   1798 O  OE1 . GLN   A 1 241 ? 42.77130 -26.90752 -36.86312 1.000 40.48920  ? 775  GLN   A OE1 1 
ATOM   1799 N  NE2 . GLN   A 1 241 ? 43.42615 -28.12503 -38.62917 1.000 36.65175  ? 775  GLN   A NE2 1 
ATOM   1800 N  N   . GLN   A 1 242 ? 47.34623 -29.14854 -36.60242 1.000 37.06382  ? 776  GLN   A N   1 
ATOM   1801 C  CA  . GLN   A 1 242 ? 47.79518 -30.27852 -37.40896 1.000 38.38581  ? 776  GLN   A CA  1 
ATOM   1802 C  C   . GLN   A 1 242 ? 47.42469 -31.60302 -36.75612 1.000 38.16465  ? 776  GLN   A C   1 
ATOM   1803 O  O   . GLN   A 1 242 ? 47.00430 -32.54545 -37.43769 1.000 43.56949  ? 776  GLN   A O   1 
ATOM   1804 C  CB  . GLN   A 1 242 ? 49.30538 -30.20155 -37.62452 1.000 45.80467  ? 776  GLN   A CB  1 
ATOM   1805 C  CG  . GLN   A 1 242 ? 49.71992 -29.41526 -38.84886 1.000 43.51742  ? 776  GLN   A CG  1 
ATOM   1806 C  CD  . GLN   A 1 242 ? 51.22615 -29.31985 -39.00008 1.000 46.65692  ? 776  GLN   A CD  1 
ATOM   1807 O  OE1 . GLN   A 1 242 ? 51.89442 -28.61024 -38.24770 1.000 44.72645  ? 776  GLN   A OE1 1 
ATOM   1808 N  NE2 . GLN   A 1 242 ? 51.76823 -30.03525 -39.97698 1.000 50.98209  ? 776  GLN   A NE2 1 
ATOM   1809 N  N   . ARG   A 1 243 ? 47.57299 -31.69284 -35.43330 1.000 39.07618  ? 777  ARG   A N   1 
ATOM   1810 C  CA  . ARG   A 1 243 ? 47.27163 -32.94088 -34.74251 1.000 38.41825  ? 777  ARG   A CA  1 
ATOM   1811 C  C   . ARG   A 1 243 ? 45.77073 -33.19606 -34.68655 1.000 36.28924  ? 777  ARG   A C   1 
ATOM   1812 O  O   . ARG   A 1 243 ? 45.32826 -34.34506 -34.79743 1.000 37.12763  ? 777  ARG   A O   1 
ATOM   1813 C  CB  . ARG   A 1 243 ? 47.86784 -32.91788 -33.33607 1.000 41.83493  ? 777  ARG   A CB  1 
ATOM   1814 C  CG  . ARG   A 1 243 ? 49.38746 -32.89811 -33.30955 1.000 41.02089  ? 777  ARG   A CG  1 
ATOM   1815 C  CD  . ARG   A 1 243 ? 49.96060 -34.14346 -33.96407 1.000 39.44705  ? 777  ARG   A CD  1 
ATOM   1816 N  NE  . ARG   A 1 243 ? 51.40258 -34.24249 -33.78056 1.000 45.09625  ? 777  ARG   A NE  1 
ATOM   1817 C  CZ  . ARG   A 1 243 ? 52.16122 -35.19497 -34.30576 1.000 44.20106  ? 777  ARG   A CZ  1 
ATOM   1818 N  NH1 . ARG   A 1 243 ? 51.64631 -36.14965 -35.06317 1.000 41.94330  ? 777  ARG   A NH1 1 
ATOM   1819 N  NH2 . ARG   A 1 243 ? 53.47013 -35.18923 -34.06536 1.000 41.62695  ? 777  ARG   A NH2 1 
ATOM   1820 N  N   . ILE   A 1 244 ? 44.97063 -32.14264 -34.50856 1.000 35.07077  ? 778  ILE   A N   1 
ATOM   1821 C  CA  . ILE   A 1 244 ? 43.52337 -32.32405 -34.46342 1.000 34.66645  ? 778  ILE   A CA  1 
ATOM   1822 C  C   . ILE   A 1 244 ? 42.99158 -32.69069 -35.84210 1.000 36.02696  ? 778  ILE   A C   1 
ATOM   1823 O  O   . ILE   A 1 244 ? 42.13586 -33.57367 -35.97745 1.000 39.79985  ? 778  ILE   A O   1 
ATOM   1824 C  CB  . ILE   A 1 244 ? 42.83706 -31.06278 -33.90969 1.000 36.34595  ? 778  ILE   A CB  1 
ATOM   1825 C  CG1 . ILE   A 1 244 ? 43.21687 -30.84188 -32.44284 1.000 35.45564  ? 778  ILE   A CG1 1 
ATOM   1826 C  CG2 . ILE   A 1 244 ? 41.33130 -31.18121 -34.05138 1.000 31.87637  ? 778  ILE   A CG2 1 
ATOM   1827 C  CD1 . ILE   A 1 244 ? 43.09324 -29.40107 -31.98639 1.000 33.62411  ? 778  ILE   A CD1 1 
ATOM   1828 N  N   . ALA   A 1 245 ? 43.49441 -32.02431 -36.88683 1.000 37.08634  ? 779  ALA   A N   1 
ATOM   1829 C  CA  . ALA   A 1 245 ? 43.09321 -32.35730 -38.25012 1.000 31.26560  ? 779  ALA   A CA  1 
ATOM   1830 C  C   . ALA   A 1 245 ? 43.40576 -33.80898 -38.58536 1.000 33.84349  ? 779  ALA   A C   1 
ATOM   1831 O  O   . ALA   A 1 245 ? 42.70603 -34.42319 -39.39914 1.000 38.44656  ? 779  ALA   A O   1 
ATOM   1832 C  CB  . ALA   A 1 245 ? 43.77857 -31.42301 -39.24458 1.000 32.73203  ? 779  ALA   A CB  1 
ATOM   1833 N  N   . GLU   A 1 246 ? 44.45657 -34.36738 -37.98153 1.000 37.45980  ? 780  GLU   A N   1 
ATOM   1834 C  CA  . GLU   A 1 246 ? 44.71276 -35.79978 -38.08957 1.000 36.10669  ? 780  GLU   A CA  1 
ATOM   1835 C  C   . GLU   A 1 246 ? 43.53025 -36.60254 -37.56006 1.000 44.09203  ? 780  GLU   A C   1 
ATOM   1836 O  O   . GLU   A 1 246 ? 42.97836 -37.46190 -38.25827 1.000 49.60654  ? 780  GLU   A O   1 
ATOM   1837 C  CB  . GLU   A 1 246 ? 45.98198 -36.16160 -37.31610 1.000 36.25645  ? 780  GLU   A CB  1 
ATOM   1838 C  CG  . GLU   A 1 246 ? 47.29363 -35.91988 -38.04038 1.000 40.71725  ? 780  GLU   A CG  1 
ATOM   1839 C  CD  . GLU   A 1 246 ? 48.48191 -36.41860 -37.23703 1.000 44.22248  ? 780  GLU   A CD  1 
ATOM   1840 O  OE1 . GLU   A 1 246 ? 48.44048 -37.58155 -36.78601 1.000 47.41410  ? 780  GLU   A OE1 1 
ATOM   1841 O  OE2 . GLU   A 1 246 ? 49.44952 -35.65080 -37.04620 1.000 50.69270  ? 780  GLU   A OE2 1 
ATOM   1842 N  N   . LEU   A 1 247 ? 43.13741 -36.33118 -36.30944 1.000 42.40729  ? 781  LEU   A N   1 
ATOM   1843 C  CA  . LEU   A 1 247 ? 42.03055 -37.04439 -35.67902 1.000 43.87472  ? 781  LEU   A CA  1 
ATOM   1844 C  C   . LEU   A 1 247 ? 40.76431 -36.95254 -36.51839 1.000 44.75079  ? 781  LEU   A C   1 
ATOM   1845 O  O   . LEU   A 1 247 ? 40.03779 -37.94177 -36.67369 1.000 49.07278  ? 781  LEU   A O   1 
ATOM   1846 C  CB  . LEU   A 1 247 ? 41.77861 -36.47660 -34.28040 1.000 40.78768  ? 781  LEU   A CB  1 
ATOM   1847 C  CG  . LEU   A 1 247 ? 42.89398 -36.62385 -33.24368 1.000 40.17693  ? 781  LEU   A CG  1 
ATOM   1848 C  CD1 . LEU   A 1 247 ? 42.62773 -35.73841 -32.03385 1.000 35.84739  ? 781  LEU   A CD1 1 
ATOM   1849 C  CD2 . LEU   A 1 247 ? 43.04991 -38.07580 -32.81962 1.000 31.60003  ? 781  LEU   A CD2 1 
ATOM   1850 N  N   . VAL   A 1 248 ? 40.48605 -35.76631 -37.06685 1.000 38.70070  ? 782  VAL   A N   1 
ATOM   1851 C  CA  . VAL   A 1 248 ? 39.32352 -35.58932 -37.93394 1.000 41.29649  ? 782  VAL   A CA  1 
ATOM   1852 C  C   . VAL   A 1 248 ? 39.42325 -36.50746 -39.14461 1.000 48.17804  ? 782  VAL   A C   1 
ATOM   1853 O  O   . VAL   A 1 248 ? 38.46021 -37.19410 -39.50862 1.000 54.36401  ? 782  VAL   A O   1 
ATOM   1854 C  CB  . VAL   A 1 248 ? 39.18870 -34.11376 -38.35173 1.000 39.72739  ? 782  VAL   A CB  1 
ATOM   1855 C  CG1 . VAL   A 1 248 ? 38.10543 -33.95381 -39.40124 1.000 41.16826  ? 782  VAL   A CG1 1 
ATOM   1856 C  CG2 . VAL   A 1 248 ? 38.90045 -33.24620 -37.13915 1.000 32.29300  ? 782  VAL   A CG2 1 
ATOM   1857 N  N   . ALA   A 1 249 ? 40.59784 -36.54227 -39.77780 1.000 51.54614  ? 783  ALA   A N   1 
ATOM   1858 C  CA  . ALA   A 1 249 ? 40.79266 -37.41678 -40.92870 1.000 47.19970  ? 783  ALA   A CA  1 
ATOM   1859 C  C   . ALA   A 1 249 ? 40.59310 -38.87697 -40.54563 1.000 53.34742  ? 783  ALA   A C   1 
ATOM   1860 O  O   . ALA   A 1 249 ? 39.92511 -39.63118 -41.26048 1.000 64.17456  ? 783  ALA   A O   1 
ATOM   1861 C  CB  . ALA   A 1 249 ? 42.18250 -37.19908 -41.52805 1.000 48.62606  ? 783  ALA   A CB  1 
ATOM   1862 N  N   . THR   A 1 250 ? 41.15658 -39.29137 -39.40831 1.000 50.50692  ? 784  THR   A N   1 
ATOM   1863 C  CA  . THR   A 1 250 ? 41.02657 -40.68230 -38.98633 1.000 53.63742  ? 784  THR   A CA  1 
ATOM   1864 C  C   . THR   A 1 250 ? 39.56919 -41.07686 -38.78376 1.000 58.15042  ? 784  THR   A C   1 
ATOM   1865 O  O   . THR   A 1 250 ? 39.20373 -42.23449 -39.02468 1.000 61.09732  ? 784  THR   A O   1 
ATOM   1866 C  CB  . THR   A 1 250 ? 41.83058 -40.91961 -37.70775 1.000 54.57588  ? 784  THR   A CB  1 
ATOM   1867 O  OG1 . THR   A 1 250 ? 43.06056 -40.18670 -37.77274 1.000 52.33194  ? 784  THR   A OG1 1 
ATOM   1868 C  CG2 . THR   A 1 250 ? 42.13775 -42.39528 -37.53127 1.000 49.89259  ? 784  THR   A CG2 1 
ATOM   1869 N  N   . GLU   A 1 251 ? 38.72361 -40.13347 -38.35959 1.000 54.98487  ? 785  GLU   A N   1 
ATOM   1870 C  CA  . GLU   A 1 251 ? 37.29721 -40.41715 -38.23884 1.000 57.78299  ? 785  GLU   A CA  1 
ATOM   1871 C  C   . GLU   A 1 251 ? 36.63686 -40.49432 -39.61002 1.000 63.55845  ? 785  GLU   A C   1 
ATOM   1872 O  O   . GLU   A 1 251 ? 36.04874 -41.51965 -39.97581 1.000 67.02376  ? 785  GLU   A O   1 
ATOM   1873 C  CB  . GLU   A 1 251 ? 36.61238 -39.35361 -37.38182 1.000 50.34803  ? 785  GLU   A CB  1 
ATOM   1874 C  CG  . GLU   A 1 251 ? 35.27845 -39.82463 -36.81251 1.000 48.39507  ? 785  GLU   A CG  1 
ATOM   1875 C  CD  . GLU   A 1 251 ? 34.74372 -38.89872 -35.74852 1.000 42.21323  ? 785  GLU   A CD  1 
ATOM   1876 O  OE1 . GLU   A 1 251 ? 35.39260 -38.76859 -34.69243 1.000 42.93683  ? 785  GLU   A OE1 1 
ATOM   1877 O  OE2 . GLU   A 1 251 ? 33.68617 -38.27943 -35.98101 1.000 40.50493  ? 785  GLU   A OE2 1 
ATOM   1878 N  N   . PHE   A 1 252 ? 36.71672 -39.40605 -40.37924 1.000 59.63837  ? 786  PHE   A N   1 
ATOM   1879 C  CA  . PHE   A 1 252 ? 36.12362 -39.37197 -41.71098 1.000 58.16688  ? 786  PHE   A CA  1 
ATOM   1880 C  C   . PHE   A 1 252 ? 36.68042 -40.48395 -42.58992 1.000 66.04551  ? 786  PHE   A C   1 
ATOM   1881 O  O   . PHE   A 1 252 ? 35.92623 -41.28373 -43.15232 1.000 72.54566  ? 786  PHE   A O   1 
ATOM   1882 C  CB  . PHE   A 1 252 ? 36.37067 -38.00328 -42.35302 1.000 50.38789  ? 786  PHE   A CB  1 
ATOM   1883 C  CG  . PHE   A 1 252 ? 35.46039 -36.91429 -41.85903 1.000 56.07119  ? 786  PHE   A CG  1 
ATOM   1884 C  CD1 . PHE   A 1 252 ? 34.32310 -36.56110 -42.57016 1.000 60.08567  ? 786  PHE   A CD1 1 
ATOM   1885 C  CD2 . PHE   A 1 252 ? 35.74420 -36.23667 -40.68672 1.000 56.91534  ? 786  PHE   A CD2 1 
ATOM   1886 C  CE1 . PHE   A 1 252 ? 33.48541 -35.55415 -42.11412 1.000 57.84737  ? 786  PHE   A CE1 1 
ATOM   1887 C  CE2 . PHE   A 1 252 ? 34.91184 -35.23019 -40.22627 1.000 54.66145  ? 786  PHE   A CE2 1 
ATOM   1888 C  CZ  . PHE   A 1 252 ? 33.78208 -34.88836 -40.94063 1.000 55.27932  ? 786  PHE   A CZ  1 
ATOM   1889 N  N   . PHE   A 1 253 ? 38.00648 -40.54809 -42.71579 1.000 72.54977  ? 787  PHE   A N   1 
ATOM   1890 C  CA  . PHE   A 1 253 ? 38.63800 -41.59886 -43.50483 1.000 77.57793  ? 787  PHE   A CA  1 
ATOM   1891 C  C   . PHE   A 1 253 ? 38.65024 -42.93385 -42.77092 1.000 77.49230  ? 787  PHE   A C   1 
ATOM   1892 O  O   . PHE   A 1 253 ? 37.66103 -43.67568 -42.79673 1.000 75.15524  ? 787  PHE   A O   1 
ATOM   1893 C  CB  . PHE   A 1 253 ? 40.07230 -41.22127 -43.88711 1.000 76.96249  ? 787  PHE   A CB  1 
ATOM   1894 C  CG  . PHE   A 1 253 ? 40.16588 -40.27946 -45.04936 1.000 84.50383  ? 787  PHE   A CG  1 
ATOM   1895 C  CD1 . PHE   A 1 253 ? 39.16470 -40.23505 -46.00485 1.000 99.74437  ? 787  PHE   A CD1 1 
ATOM   1896 C  CD2 . PHE   A 1 253 ? 41.27079 -39.45889 -45.20347 1.000 81.68135  ? 787  PHE   A CD2 1 
ATOM   1897 C  CE1 . PHE   A 1 253 ? 39.25298 -39.37516 -47.08241 1.000 100.00437 ? 787  PHE   A CE1 1 
ATOM   1898 C  CE2 . PHE   A 1 253 ? 41.36722 -38.59924 -46.27977 1.000 96.75437  ? 787  PHE   A CE2 1 
ATOM   1899 C  CZ  . PHE   A 1 253 ? 40.35712 -38.55707 -47.22084 1.000 98.73437  ? 787  PHE   A CZ  1 
ATOM   1900 N  N   . ASP   A 1 254 ? 39.75760 -43.23296 -42.08820 1.000 79.03453  ? 788  ASP   A N   1 
ATOM   1901 C  CA  . ASP   A 1 254 ? 40.03970 -44.58362 -41.60963 1.000 86.15740  ? 788  ASP   A CA  1 
ATOM   1902 C  C   . ASP   A 1 254 ? 39.08457 -45.09209 -40.53336 1.000 86.40148  ? 788  ASP   A C   1 
ATOM   1903 O  O   . ASP   A 1 254 ? 39.47163 -45.93079 -39.71382 1.000 89.41004  ? 788  ASP   A O   1 
ATOM   1904 C  CB  . ASP   A 1 254 ? 41.47905 -44.66200 -41.09560 1.000 92.08496  ? 788  ASP   A CB  1 
ATOM   1905 C  CG  . ASP   A 1 254 ? 42.37277 -45.48175 -42.00392 1.000 99.27066  ? 788  ASP   A CG  1 
ATOM   1906 O  OD1 . ASP   A 1 254 ? 41.84931 -46.38594 -42.68817 1.000 95.27887  ? 788  ASP   A OD1 1 
ATOM   1907 O  OD2 . ASP   A 1 254 ? 43.59382 -45.22406 -42.03655 1.000 91.65848  ? 788  ASP   A OD2 1 
ATOM   1908 N  N   . GLN   A 1 255 ? 37.84989 -44.58357 -40.52052 1.000 81.96213  ? 789  GLN   A N   1 
ATOM   1909 C  CA  . GLN   A 1 255 ? 36.71686 -45.23868 -39.85678 1.000 78.88875  ? 789  GLN   A CA  1 
ATOM   1910 C  C   . GLN   A 1 255 ? 37.01601 -45.56865 -38.39496 1.000 84.37036  ? 789  GLN   A C   1 
ATOM   1911 O  O   . GLN   A 1 255 ? 36.64318 -46.62760 -37.88573 1.000 84.48943  ? 789  GLN   A O   1 
ATOM   1912 C  CB  . GLN   A 1 255 ? 36.31413 -46.49689 -40.62977 1.000 78.42907  ? 789  GLN   A CB  1 
ATOM   1913 C  CG  . GLN   A 1 255 ? 34.82419 -46.63324 -40.90053 1.000 73.14621  ? 789  GLN   A CG  1 
ATOM   1914 C  CD  . GLN   A 1 255 ? 34.53321 -47.57348 -42.05502 1.000 74.38035  ? 789  GLN   A CD  1 
ATOM   1915 O  OE1 . GLN   A 1 255 ? 35.29038 -47.63725 -43.02365 1.000 66.19082  ? 789  GLN   A OE1 1 
ATOM   1916 N  NE2 . GLN   A 1 255 ? 33.42846 -48.30353 -41.96123 1.000 78.47994  ? 789  GLN   A NE2 1 
ATOM   1917 N  N   . GLY   A 1 256 ? 37.69039 -44.65062 -37.71036 1.000 79.79387  ? 790  GLY   A N   1 
ATOM   1918 C  CA  . GLY   A 1 256 ? 38.06833 -44.87168 -36.32715 1.000 69.74529  ? 790  GLY   A CA  1 
ATOM   1919 C  C   . GLY   A 1 256 ? 37.79377 -43.68706 -35.42402 1.000 59.93094  ? 790  GLY   A C   1 
ATOM   1920 O  O   . GLY   A 1 256 ? 36.88702 -42.89698 -35.68210 1.000 56.94229  ? 790  GLY   A O   1 
ATOM   1921 N  N   . ASN   A 1 277 ? 46.86401 -35.08332 -48.48948 1.000 56.69752  ? 811  ASN   A N   1 
ATOM   1922 C  CA  . ASN   A 1 277 ? 46.66605 -34.67689 -49.87535 1.000 57.02981  ? 811  ASN   A CA  1 
ATOM   1923 C  C   . ASN   A 1 277 ? 45.37355 -33.88878 -50.02434 1.000 57.27383  ? 811  ASN   A C   1 
ATOM   1924 O  O   . ASN   A 1 277 ? 45.38960 -32.68137 -50.26830 1.000 54.54733  ? 811  ASN   A O   1 
ATOM   1925 C  CB  . ASN   A 1 277 ? 46.63354 -35.89860 -50.79432 1.000 55.67350  ? 811  ASN   A CB  1 
ATOM   1926 C  CG  . ASN   A 1 277 ? 47.99987 -36.24708 -51.35127 1.000 71.64684  ? 811  ASN   A CG  1 
ATOM   1927 O  OD1 . ASN   A 1 277 ? 48.43873 -37.39397 -51.27391 1.000 72.92120  ? 811  ASN   A OD1 1 
ATOM   1928 N  ND2 . ASN   A 1 277 ? 48.68200 -35.25583 -51.91381 1.000 66.90606  ? 811  ASN   A ND2 1 
ATOM   1929 N  N   . LYS   A 1 278 ? 44.24776 -34.59102 -49.88075 1.000 60.48834  ? 812  LYS   A N   1 
ATOM   1930 C  CA  . LYS   A 1 278 ? 42.94317 -33.95443 -49.99286 1.000 54.41992  ? 812  LYS   A CA  1 
ATOM   1931 C  C   . LYS   A 1 278 ? 42.60477 -33.12726 -48.75616 1.000 54.56414  ? 812  LYS   A C   1 
ATOM   1932 O  O   . LYS   A 1 278 ? 41.66513 -32.32379 -48.79933 1.000 54.20840  ? 812  LYS   A O   1 
ATOM   1933 C  CB  . LYS   A 1 278 ? 41.84937 -35.00312 -50.20999 1.000 58.07582  ? 812  LYS   A CB  1 
ATOM   1934 C  CG  . LYS   A 1 278 ? 41.98627 -36.25438 -49.35340 1.000 59.90488  ? 812  LYS   A CG  1 
ATOM   1935 C  CD  . LYS   A 1 278 ? 42.82139 -37.33266 -50.03904 1.000 59.97808  ? 812  LYS   A CD  1 
ATOM   1936 C  CE  . LYS   A 1 278 ? 43.59602 -38.17055 -49.03410 1.000 60.67704  ? 812  LYS   A CE  1 
ATOM   1937 N  NZ  . LYS   A 1 278 ? 44.54148 -37.34365 -48.23436 1.000 53.48256  ? 812  LYS   A NZ  1 
ATOM   1938 N  N   . ILE   A 1 279 ? 43.35783 -33.29173 -47.66932 1.000 49.66338  ? 813  ILE   A N   1 
ATOM   1939 C  CA  . ILE   A 1 279 ? 43.07277 -32.66622 -46.37684 1.000 47.07556  ? 813  ILE   A CA  1 
ATOM   1940 C  C   . ILE   A 1 279 ? 43.28165 -31.15676 -46.42687 1.000 44.34684  ? 813  ILE   A C   1 
ATOM   1941 O  O   . ILE   A 1 279 ? 42.39351 -30.41582 -45.98684 1.000 47.11353  ? 813  ILE   A O   1 
ATOM   1942 C  CB  . ILE   A 1 279 ? 43.93403 -33.28362 -45.26456 1.000 45.24962  ? 813  ILE   A CB  1 
ATOM   1943 C  CG1 . ILE   A 1 279 ? 43.73164 -34.79553 -45.19927 1.000 50.29681  ? 813  ILE   A CG1 1 
ATOM   1944 C  CG2 . ILE   A 1 279 ? 43.63212 -32.64094 -43.92621 1.000 39.82041  ? 813  ILE   A CG2 1 
ATOM   1945 C  CD1 . ILE   A 1 279 ? 42.28860 -35.22487 -45.26385 1.000 53.26207  ? 813  ILE   A CD1 1 
ATOM   1946 N  N   . PRO   A 1 280 ? 44.42333 -30.64644 -46.91649 1.000 45.36990  ? 814  PRO   A N   1 
ATOM   1947 C  CA  . PRO   A 1 280 ? 44.61492 -29.18208 -46.89449 1.000 42.65806  ? 814  PRO   A CA  1 
ATOM   1948 C  C   . PRO   A 1 280 ? 43.53861 -28.41219 -47.63773 1.000 43.13291  ? 814  PRO   A C   1 
ATOM   1949 O  O   . PRO   A 1 280 ? 43.10154 -27.35568 -47.16435 1.000 43.34885  ? 814  PRO   A O   1 
ATOM   1950 C  CB  . PRO   A 1 280 ? 45.99604 -29.00376 -47.55004 1.000 46.18213  ? 814  PRO   A CB  1 
ATOM   1951 C  CG  . PRO   A 1 280 ? 46.69732 -30.27377 -47.25114 1.000 40.88374  ? 814  PRO   A CG  1 
ATOM   1952 C  CD  . PRO   A 1 280 ? 45.64765 -31.32812 -47.38811 1.000 46.32918  ? 814  PRO   A CD  1 
ATOM   1953 N  N   . SER   A 1 281 ? 43.08380 -28.92025 -48.78498 1.000 45.46120  ? 815  SER   A N   1 
ATOM   1954 C  CA  . SER   A 1 281 ? 42.06285 -28.20962 -49.54881 1.000 47.36877  ? 815  SER   A CA  1 
ATOM   1955 C  C   . SER   A 1 281 ? 40.72420 -28.22830 -48.82251 1.000 42.36543  ? 815  SER   A C   1 
ATOM   1956 O  O   . SER   A 1 281 ? 40.04411 -27.20028 -48.72803 1.000 39.59992  ? 815  SER   A O   1 
ATOM   1957 C  CB  . SER   A 1 281 ? 41.92806 -28.81790 -50.94450 1.000 46.32264  ? 815  SER   A CB  1 
ATOM   1958 O  OG  . SER   A 1 281 ? 41.77429 -30.22417 -50.87673 1.000 50.24336  ? 815  SER   A OG  1 
ATOM   1959 N  N   . MET   A 1 282 ? 40.33161 -29.39214 -48.29693 1.000 43.51425  ? 816  MET   A N   1 
ATOM   1960 C  CA  . MET   A 1 282 ? 39.07457 -29.48398 -47.56141 1.000 41.89348  ? 816  MET   A CA  1 
ATOM   1961 C  C   . MET   A 1 282 ? 39.09103 -28.60891 -46.31543 1.000 42.95845  ? 816  MET   A C   1 
ATOM   1962 O  O   . MET   A 1 282 ? 38.04102 -28.11367 -45.88936 1.000 48.98905  ? 816  MET   A O   1 
ATOM   1963 C  CB  . MET   A 1 282 ? 38.78962 -30.93751 -47.18356 1.000 40.06057  ? 816  MET   A CB  1 
ATOM   1964 C  CG  . MET   A 1 282 ? 38.16566 -31.76312 -48.29601 1.000 41.19130  ? 816  MET   A CG  1 
ATOM   1965 S  SD  . MET   A 1 282 ? 38.61121 -33.50606 -48.17922 1.000 57.41026  ? 816  MET   A SD  1 
ATOM   1966 C  CE  . MET   A 1 282 ? 37.00505 -34.27901 -48.35206 1.000 53.90580  ? 816  MET   A CE  1 
ATOM   1967 N  N   . GLN   A 1 283 ? 40.26842 -28.40174 -45.72239 1.000 42.18741  ? 817  GLN   A N   1 
ATOM   1968 C  CA  . GLN   A 1 283 ? 40.35717 -27.55072 -44.54135 1.000 42.48871  ? 817  GLN   A CA  1 
ATOM   1969 C  C   . GLN   A 1 283 ? 40.12459 -26.08695 -44.89757 1.000 46.91422  ? 817  GLN   A C   1 
ATOM   1970 O  O   . GLN   A 1 283 ? 39.37374 -25.38818 -44.20735 1.000 45.96709  ? 817  GLN   A O   1 
ATOM   1971 C  CB  . GLN   A 1 283 ? 41.71515 -27.73418 -43.86298 1.000 47.25761  ? 817  GLN   A CB  1 
ATOM   1972 C  CG  . GLN   A 1 283 ? 41.86776 -29.05146 -43.11258 1.000 38.90399  ? 817  GLN   A CG  1 
ATOM   1973 C  CD  . GLN   A 1 283 ? 40.93295 -29.15860 -41.92378 1.000 40.12297  ? 817  GLN   A CD  1 
ATOM   1974 O  OE1 . GLN   A 1 283 ? 39.76230 -29.50558 -42.06956 1.000 46.88674  ? 817  GLN   A OE1 1 
ATOM   1975 N  NE2 . GLN   A 1 283 ? 41.44771 -28.85598 -40.73625 1.000 44.22869  ? 817  GLN   A NE2 1 
ATOM   1976 N  N   . VAL   A 1 284 ? 40.75310 -25.60769 -45.97535 1.000 45.13678  ? 818  VAL   A N   1 
ATOM   1977 C  CA  . VAL   A 1 284 ? 40.56150 -24.22228 -46.39955 1.000 44.70431  ? 818  VAL   A CA  1 
ATOM   1978 C  C   . VAL   A 1 284 ? 39.11121 -23.98405 -46.79955 1.000 42.31101  ? 818  VAL   A C   1 
ATOM   1979 O  O   . VAL   A 1 284 ? 38.53195 -22.93224 -46.49852 1.000 37.38703  ? 818  VAL   A O   1 
ATOM   1980 C  CB  . VAL   A 1 284 ? 41.53413 -23.87815 -47.54366 1.000 43.94880  ? 818  VAL   A CB  1 
ATOM   1981 C  CG1 . VAL   A 1 284 ? 41.18319 -22.53376 -48.16559 1.000 38.65306  ? 818  VAL   A CG1 1 
ATOM   1982 C  CG2 . VAL   A 1 284 ? 42.96723 -23.87554 -47.03704 1.000 39.44851  ? 818  VAL   A CG2 1 
ATOM   1983 N  N   . GLY   A 1 285 ? 38.49979 -24.95895 -47.47608 1.000 42.31524  ? 819  GLY   A N   1 
ATOM   1984 C  CA  . GLY   A 1 285 ? 37.09189 -24.83694 -47.81763 1.000 39.21772  ? 819  GLY   A CA  1 
ATOM   1985 C  C   . GLY   A 1 285 ? 36.19944 -24.77403 -46.59238 1.000 37.56153  ? 819  GLY   A C   1 
ATOM   1986 O  O   . GLY   A 1 285 ? 35.20614 -24.04329 -46.57245 1.000 37.10470  ? 819  GLY   A O   1 
ATOM   1987 N  N   . PHE   A 1 286 ? 36.54026 -25.54117 -45.55309 1.000 41.32745  ? 820  PHE   A N   1 
ATOM   1988 C  CA  . PHE   A 1 286 ? 35.77866 -25.48603 -44.30938 1.000 38.95689  ? 820  PHE   A CA  1 
ATOM   1989 C  C   . PHE   A 1 286 ? 35.95602 -24.14254 -43.61366 1.000 39.49469  ? 820  PHE   A C   1 
ATOM   1990 O  O   . PHE   A 1 286 ? 34.98577 -23.56925 -43.10440 1.000 39.00358  ? 820  PHE   A O   1 
ATOM   1991 C  CB  . PHE   A 1 286 ? 36.19963 -26.62793 -43.38446 1.000 44.19812  ? 820  PHE   A CB  1 
ATOM   1992 C  CG  . PHE   A 1 286 ? 35.29035 -26.81815 -42.20431 1.000 46.46021  ? 820  PHE   A CG  1 
ATOM   1993 C  CD1 . PHE   A 1 286 ? 33.99987 -27.29118 -42.37298 1.000 47.54164  ? 820  PHE   A CD1 1 
ATOM   1994 C  CD2 . PHE   A 1 286 ? 35.72769 -26.51920 -40.92398 1.000 43.58287  ? 820  PHE   A CD2 1 
ATOM   1995 C  CE1 . PHE   A 1 286 ? 33.16151 -27.46468 -41.28630 1.000 45.55756  ? 820  PHE   A CE1 1 
ATOM   1996 C  CE2 . PHE   A 1 286 ? 34.89454 -26.68985 -39.83382 1.000 41.47439  ? 820  PHE   A CE2 1 
ATOM   1997 C  CZ  . PHE   A 1 286 ? 33.60984 -27.16317 -40.01538 1.000 45.53871  ? 820  PHE   A CZ  1 
ATOM   1998 N  N   . ILE   A 1 287 ? 37.18818 -23.62716 -43.58044 1.000 39.54373  ? 821  ILE   A N   1 
ATOM   1999 C  CA  . ILE   A 1 287 ? 37.43690 -22.31891 -42.97955 1.000 37.38800  ? 821  ILE   A CA  1 
ATOM   2000 C  C   . ILE   A 1 287 ? 36.69321 -21.22922 -43.74261 1.000 39.98552  ? 821  ILE   A C   1 
ATOM   2001 O  O   . ILE   A 1 287 ? 36.11854 -20.31053 -43.14436 1.000 44.08871  ? 821  ILE   A O   1 
ATOM   2002 C  CB  . ILE   A 1 287 ? 38.95137 -22.03955 -42.92131 1.000 46.58972  ? 821  ILE   A CB  1 
ATOM   2003 C  CG1 . ILE   A 1 287 ? 39.67157 -23.10816 -42.09696 1.000 38.25564  ? 821  ILE   A CG1 1 
ATOM   2004 C  CG2 . ILE   A 1 287 ? 39.22050 -20.64632 -42.37594 1.000 39.02795  ? 821  ILE   A CG2 1 
ATOM   2005 C  CD1 . ILE   A 1 287 ? 41.11854 -22.77120 -41.78568 1.000 40.35189  ? 821  ILE   A CD1 1 
ATOM   2006 N  N   . ASP   A 1 288 ? 36.68078 -21.32022 -45.07297 1.000 41.77312  ? 822  ASP   A N   1 
ATOM   2007 C  CA  . ASP   A 1 288 ? 36.03073 -20.29475 -45.88164 1.000 39.42432  ? 822  ASP   A CA  1 
ATOM   2008 C  C   . ASP   A 1 288 ? 34.51606 -20.34858 -45.73040 1.000 38.40990  ? 822  ASP   A C   1 
ATOM   2009 O  O   . ASP   A 1 288 ? 33.86560 -19.31813 -45.52063 1.000 43.76737  ? 822  ASP   A O   1 
ATOM   2010 C  CB  . ASP   A 1 288 ? 36.42691 -20.45721 -47.34920 1.000 43.15350  ? 822  ASP   A CB  1 
ATOM   2011 C  CG  . ASP   A 1 288 ? 37.68662 -19.69851 -47.69779 1.000 44.65180  ? 822  ASP   A CG  1 
ATOM   2012 O  OD1 . ASP   A 1 288 ? 38.15415 -18.90937 -46.85196 1.000 43.50977  ? 822  ASP   A OD1 1 
ATOM   2013 O  OD2 . ASP   A 1 288 ? 38.21067 -19.89328 -48.81482 1.000 47.89146  ? 822  ASP   A OD2 1 
ATOM   2014 N  N   . ALA   A 1 289 ? 33.93584 -21.54575 -45.82785 1.000 35.91664  ? 823  ALA   A N   1 
ATOM   2015 C  CA  . ALA   A 1 289 ? 32.48146 -21.65689 -45.85216 1.000 35.79578  ? 823  ALA   A CA  1 
ATOM   2016 C  C   . ALA   A 1 289 ? 31.87260 -21.45234 -44.46949 1.000 42.17340  ? 823  ALA   A C   1 
ATOM   2017 O  O   . ALA   A 1 289 ? 30.82073 -20.81614 -44.33845 1.000 46.56142  ? 823  ALA   A O   1 
ATOM   2018 C  CB  . ALA   A 1 289 ? 32.07144 -23.01588 -46.41825 1.000 29.52391  ? 823  ALA   A CB  1 
ATOM   2019 N  N   . ILE   A 1 290 ? 32.51355 -21.97272 -43.42866 1.000 40.75754  ? 824  ILE   A N   1 
ATOM   2020 C  CA  . ILE   A 1 290 ? 31.89075 -22.13441 -42.12159 1.000 38.19933  ? 824  ILE   A CA  1 
ATOM   2021 C  C   . ILE   A 1 290 ? 32.49156 -21.19331 -41.08156 1.000 44.66715  ? 824  ILE   A C   1 
ATOM   2022 O  O   . ILE   A 1 290 ? 31.76516 -20.48427 -40.38294 1.000 42.71172  ? 824  ILE   A O   1 
ATOM   2023 C  CB  . ILE   A 1 290 ? 31.98122 -23.60345 -41.65179 1.000 38.67148  ? 824  ILE   A CB  1 
ATOM   2024 C  CG1 . ILE   A 1 290 ? 31.51096 -24.55007 -42.76019 1.000 39.88189  ? 824  ILE   A CG1 1 
ATOM   2025 C  CG2 . ILE   A 1 290 ? 31.18965 -23.80125 -40.36931 1.000 43.36267  ? 824  ILE   A CG2 1 
ATOM   2026 C  CD1 . ILE   A 1 290 ? 30.00744 -24.75935 -42.81230 1.000 43.25834  ? 824  ILE   A CD1 1 
ATOM   2027 N  N   . CYS   A 1 291 ? 33.81839 -21.17779 -40.96105 1.000 36.43438  ? 825  CYS   A N   1 
ATOM   2028 C  CA  . CYS   A 1 291 ? 34.44699 -20.67401 -39.74490 1.000 34.40090  ? 825  CYS   A CA  1 
ATOM   2029 C  C   . CYS   A 1 291 ? 34.70250 -19.16781 -39.75693 1.000 39.87283  ? 825  CYS   A C   1 
ATOM   2030 O  O   . CYS   A 1 291 ? 34.40403 -18.48831 -38.77054 1.000 38.25602  ? 825  CYS   A O   1 
ATOM   2031 C  CB  . CYS   A 1 291 ? 35.76153 -21.41956 -39.49625 1.000 37.59060  ? 825  CYS   A CB  1 
ATOM   2032 S  SG  . CYS   A 1 291 ? 35.64485 -23.20975 -39.64618 1.000 41.17726  ? 825  CYS   A SG  1 
ATOM   2033 N  N   . LEU   A 1 292 ? 35.25332 -18.63131 -40.85144 1.000 41.12355  ? 826  LEU   A N   1 
ATOM   2034 C  CA  . LEU   A 1 292 ? 35.82478 -17.28414 -40.81023 1.000 43.11795  ? 826  LEU   A CA  1 
ATOM   2035 C  C   . LEU   A 1 292 ? 34.77716 -16.22026 -40.49346 1.000 45.31397  ? 826  LEU   A C   1 
ATOM   2036 O  O   . LEU   A 1 292 ? 35.03339 -15.31216 -39.69446 1.000 48.44754  ? 826  LEU   A O   1 
ATOM   2037 C  CB  . LEU   A 1 292 ? 36.53025 -16.96566 -42.12955 1.000 41.66238  ? 826  LEU   A CB  1 
ATOM   2038 C  CG  . LEU   A 1 292 ? 38.03801 -17.23038 -42.10961 1.000 46.05658  ? 826  LEU   A CG  1 
ATOM   2039 C  CD1 . LEU   A 1 292 ? 38.66703 -17.01803 -43.48304 1.000 47.05901  ? 826  LEU   A CD1 1 
ATOM   2040 C  CD2 . LEU   A 1 292 ? 38.71171 -16.36490 -41.05747 1.000 47.85656  ? 826  LEU   A CD2 1 
ATOM   2041 N  N   . GLN   A 1 293 ? 33.59902 -16.30058 -41.11468 1.000 45.28331  ? 827  GLN   A N   1 
ATOM   2042 C  CA  . GLN   A 1 293 ? 32.55105 -15.32642 -40.81984 1.000 48.62782  ? 827  GLN   A CA  1 
ATOM   2043 C  C   . GLN   A 1 293 ? 32.09747 -15.42995 -39.36803 1.000 47.34137  ? 827  GLN   A C   1 
ATOM   2044 O  O   . GLN   A 1 293 ? 31.91025 -14.41352 -38.68815 1.000 48.35249  ? 827  GLN   A O   1 
ATOM   2045 C  CB  . GLN   A 1 293 ? 31.36516 -15.52348 -41.76169 1.000 48.90293  ? 827  GLN   A CB  1 
ATOM   2046 C  CG  . GLN   A 1 293 ? 31.60004 -15.04366 -43.17834 1.000 50.50112  ? 827  GLN   A CG  1 
ATOM   2047 C  CD  . GLN   A 1 293 ? 30.45421 -15.40886 -44.10116 1.000 59.98041  ? 827  GLN   A CD  1 
ATOM   2048 O  OE1 . GLN   A 1 293 ? 30.32299 -16.55696 -44.52372 1.000 62.39126  ? 827  GLN   A OE1 1 
ATOM   2049 N  NE2 . GLN   A 1 293 ? 29.61200 -14.43253 -44.41166 1.000 53.74206  ? 827  GLN   A NE2 1 
ATOM   2050 N  N   . LEU   A 1 294 ? 31.90396 -16.65960 -38.88284 1.000 41.09959  ? 828  LEU   A N   1 
ATOM   2051 C  CA  . LEU   A 1 294 ? 31.47902 -16.88053 -37.50267 1.000 42.20649  ? 828  LEU   A CA  1 
ATOM   2052 C  C   . LEU   A 1 294 ? 32.43014 -16.22131 -36.51164 1.000 41.00950  ? 828  LEU   A C   1 
ATOM   2053 O  O   . LEU   A 1 294 ? 32.00458 -15.48677 -35.61299 1.000 42.49323  ? 828  LEU   A O   1 
ATOM   2054 C  CB  . LEU   A 1 294 ? 31.38301 -18.38271 -37.23093 1.000 36.92765  ? 828  LEU   A CB  1 
ATOM   2055 C  CG  . LEU   A 1 294 ? 31.11163 -18.82248 -35.79215 1.000 35.36851  ? 828  LEU   A CG  1 
ATOM   2056 C  CD1 . LEU   A 1 294 ? 29.72714 -18.37906 -35.33089 1.000 37.07630  ? 828  LEU   A CD1 1 
ATOM   2057 C  CD2 . LEU   A 1 294 ? 31.27033 -20.32998 -35.66697 1.000 38.46574  ? 828  LEU   A CD2 1 
ATOM   2058 N  N   . TYR   A 1 295 ? 33.72988 -16.47568 -36.66524 1.000 41.12889  ? 829  TYR   A N   1 
ATOM   2059 C  CA  . TYR   A 1 295 ? 34.71106 -15.90520 -35.75127 1.000 44.56876  ? 829  TYR   A CA  1 
ATOM   2060 C  C   . TYR   A 1 295 ? 34.88122 -14.40856 -35.97502 1.000 43.54248  ? 829  TYR   A C   1 
ATOM   2061 O  O   . TYR   A 1 295 ? 35.20983 -13.67694 -35.03393 1.000 38.74855  ? 829  TYR   A O   1 
ATOM   2062 C  CB  . TYR   A 1 295 ? 36.04193 -16.63729 -35.90536 1.000 35.68424  ? 829  TYR   A CB  1 
ATOM   2063 C  CG  . TYR   A 1 295 ? 35.99417 -18.05262 -35.38187 1.000 30.36904  ? 829  TYR   A CG  1 
ATOM   2064 C  CD1 . TYR   A 1 295 ? 35.79559 -18.30683 -34.03060 1.000 33.01036  ? 829  TYR   A CD1 1 
ATOM   2065 C  CD2 . TYR   A 1 295 ? 36.12999 -19.13710 -36.23807 1.000 32.72558  ? 829  TYR   A CD2 1 
ATOM   2066 C  CE1 . TYR   A 1 295 ? 35.74570 -19.59871 -33.54445 1.000 28.56136  ? 829  TYR   A CE1 1 
ATOM   2067 C  CE2 . TYR   A 1 295 ? 36.07926 -20.43484 -35.76144 1.000 35.18867  ? 829  TYR   A CE2 1 
ATOM   2068 C  CZ  . TYR   A 1 295 ? 35.88659 -20.65937 -34.41316 1.000 33.75256  ? 829  TYR   A CZ  1 
ATOM   2069 O  OH  . TYR   A 1 295 ? 35.83531 -21.94609 -33.92604 1.000 32.21698  ? 829  TYR   A OH  1 
ATOM   2070 N  N   . GLU   A 1 296 ? 34.66105 -13.93518 -37.20383 1.000 47.10545  ? 830  GLU   A N   1 
ATOM   2071 C  CA  . GLU   A 1 296 ? 34.64802 -12.49631 -37.44792 1.000 47.45824  ? 830  GLU   A CA  1 
ATOM   2072 C  C   . GLU   A 1 296 ? 33.49840 -11.83068 -36.70196 1.000 47.31177  ? 830  GLU   A C   1 
ATOM   2073 O  O   . GLU   A 1 296 ? 33.67964 -10.79506 -36.05091 1.000 45.10635  ? 830  GLU   A O   1 
ATOM   2074 C  CB  . GLU   A 1 296 ? 34.54475 -12.21493 -38.94769 1.000 47.15043  ? 830  GLU   A CB  1 
ATOM   2075 C  CG  . GLU   A 1 296 ? 35.87604 -12.00979 -39.65087 1.000 46.38143  ? 830  GLU   A CG  1 
ATOM   2076 C  CD  . GLU   A 1 296 ? 35.73853 -12.02096 -41.16017 1.000 52.25387  ? 830  GLU   A CD  1 
ATOM   2077 O  OE1 . GLU   A 1 296 ? 34.70342 -11.53737 -41.66655 1.000 57.89099  ? 830  GLU   A OE1 1 
ATOM   2078 O  OE2 . GLU   A 1 296 ? 36.66250 -12.51469 -41.84022 1.000 50.43431  ? 830  GLU   A OE2 1 
ATOM   2079 N  N   . ALA   A 1 297 ? 32.30227 -12.41962 -36.78378 1.000 51.65224  ? 831  ALA   A N   1 
ATOM   2080 C  CA  . ALA   A 1 297 ? 31.14018 -11.83281 -36.12534 1.000 47.67267  ? 831  ALA   A CA  1 
ATOM   2081 C  C   . ALA   A 1 297 ? 31.28287 -11.87600 -34.60971 1.000 47.02394  ? 831  ALA   A C   1 
ATOM   2082 O  O   . ALA   A 1 297 ? 30.83246 -10.96081 -33.91068 1.000 48.28507  ? 831  ALA   A O   1 
ATOM   2083 C  CB  . ALA   A 1 297 ? 29.86757 -12.55414 -36.56828 1.000 49.77926  ? 831  ALA   A CB  1 
ATOM   2084 N  N   . LEU   A 1 298 ? 31.91107 -12.93054 -34.08334 1.000 49.34871  ? 832  LEU   A N   1 
ATOM   2085 C  CA  . LEU   A 1 298 ? 32.09570 -13.03698 -32.63944 1.000 48.30712  ? 832  LEU   A CA  1 
ATOM   2086 C  C   . LEU   A 1 298 ? 33.00119 -11.92971 -32.11535 1.000 51.63753  ? 832  LEU   A C   1 
ATOM   2087 O  O   . LEU   A 1 298 ? 32.78396 -11.40729 -31.01508 1.000 49.68268  ? 832  LEU   A O   1 
ATOM   2088 C  CB  . LEU   A 1 298 ? 32.66496 -14.41056 -32.28521 1.000 43.81834  ? 832  LEU   A CB  1 
ATOM   2089 C  CG  . LEU   A 1 298 ? 32.82466 -14.71200 -30.79391 1.000 42.76703  ? 832  LEU   A CG  1 
ATOM   2090 C  CD1 . LEU   A 1 298 ? 31.51447 -14.47949 -30.05804 1.000 46.70776  ? 832  LEU   A CD1 1 
ATOM   2091 C  CD2 . LEU   A 1 298 ? 33.32192 -16.13316 -30.57659 1.000 37.00803  ? 832  LEU   A CD2 1 
ATOM   2092 N  N   . THR   A 1 299 ? 34.02219 -11.55643 -32.89127 1.000 49.57495  ? 833  THR   A N   1 
ATOM   2093 C  CA  . THR   A 1 299 ? 34.91473 -10.48195 -32.46988 1.000 46.66558  ? 833  THR   A CA  1 
ATOM   2094 C  C   . THR   A 1 299 ? 34.20719 -9.13177  -32.46317 1.000 50.99224  ? 833  THR   A C   1 
ATOM   2095 O  O   . THR   A 1 299 ? 34.55755 -8.25389  -31.66631 1.000 51.51026  ? 833  THR   A O   1 
ATOM   2096 C  CB  . THR   A 1 299 ? 36.14670 -10.43150 -33.37426 1.000 51.46588  ? 833  THR   A CB  1 
ATOM   2097 O  OG1 . THR   A 1 299 ? 36.60383 -11.76420 -33.64233 1.000 45.64325  ? 833  THR   A OG1 1 
ATOM   2098 C  CG2 . THR   A 1 299 ? 37.26349 -9.63536  -32.70904 1.000 50.80317  ? 833  THR   A CG2 1 
ATOM   2099 N  N   . HIS   A 1 300 ? 33.21711 -8.94335  -33.33820 1.000 50.98528  ? 834  HIS   A N   1 
ATOM   2100 C  CA  . HIS   A 1 300 ? 32.44196 -7.70714  -33.31176 1.000 48.89052  ? 834  HIS   A CA  1 
ATOM   2101 C  C   . HIS   A 1 300 ? 31.61332 -7.60536  -32.03620 1.000 48.54700  ? 834  HIS   A C   1 
ATOM   2102 O  O   . HIS   A 1 300 ? 31.42380 -6.50825  -31.49750 1.000 57.62792  ? 834  HIS   A O   1 
ATOM   2103 C  CB  . HIS   A 1 300 ? 31.54349 -7.62079  -34.54525 1.000 49.93317  ? 834  HIS   A CB  1 
ATOM   2104 C  CG  . HIS   A 1 300 ? 32.29013 -7.65147  -35.84336 1.000 61.50907  ? 834  HIS   A CG  1 
ATOM   2105 N  ND1 . HIS   A 1 300 ? 31.71322 -8.07490  -37.02156 1.000 65.88948  ? 834  HIS   A ND1 1 
ATOM   2106 C  CD2 . HIS   A 1 300 ? 33.56269 -7.30441  -36.15163 1.000 62.75795  ? 834  HIS   A CD2 1 
ATOM   2107 C  CE1 . HIS   A 1 300 ? 32.59828 -7.99162  -37.99877 1.000 62.12912  ? 834  HIS   A CE1 1 
ATOM   2108 N  NE2 . HIS   A 1 300 ? 33.72874 -7.52662  -37.49774 1.000 70.02941  ? 834  HIS   A NE2 1 
ATOM   2109 N  N   . VAL   A 1 301 ? 31.11451 -8.73900  -31.53728 1.000 47.87952  ? 835  VAL   A N   1 
ATOM   2110 C  CA  . VAL   A 1 301 ? 30.34272 -8.73268  -30.29838 1.000 50.58900  ? 835  VAL   A CA  1 
ATOM   2111 C  C   . VAL   A 1 301 ? 31.25604 -8.48200  -29.10319 1.000 49.72844  ? 835  VAL   A C   1 
ATOM   2112 O  O   . VAL   A 1 301 ? 30.88119 -7.78482  -28.15280 1.000 50.54159  ? 835  VAL   A O   1 
ATOM   2113 C  CB  . VAL   A 1 301 ? 29.56274 -10.05279 -30.15317 1.000 51.97732  ? 835  VAL   A CB  1 
ATOM   2114 C  CG1 . VAL   A 1 301 ? 28.79741 -10.08430 -28.83710 1.000 48.63515  ? 835  VAL   A CG1 1 
ATOM   2115 C  CG2 . VAL   A 1 301 ? 28.61739 -10.24853 -31.33102 1.000 46.22798  ? 835  VAL   A CG2 1 
ATOM   2116 N  N   . SER   A 1 302 ? 32.46409 -9.04349  -29.12974 1.000 54.10055  ? 836  SER   A N   1 
ATOM   2117 C  CA  . SER   A 1 302 ? 33.45846 -8.80746  -28.08674 1.000 55.77396  ? 836  SER   A CA  1 
ATOM   2118 C  C   . SER   A 1 302 ? 34.83532 -8.88080  -28.72694 1.000 53.05766  ? 836  SER   A C   1 
ATOM   2119 O  O   . SER   A 1 302 ? 35.23231 -9.94136  -29.21938 1.000 54.25273  ? 836  SER   A O   1 
ATOM   2120 C  CB  . SER   A 1 302 ? 33.32703 -9.82732  -26.95198 1.000 50.78605  ? 836  SER   A CB  1 
ATOM   2121 O  OG  . SER   A 1 302 ? 34.58891 -10.34739 -26.57262 1.000 50.80023  ? 836  SER   A OG  1 
ATOM   2122 N  N   . GLU   A 1 303 ? 35.55654 -7.75542  -28.72463 1.000 55.63209  ? 837  GLU   A N   1 
ATOM   2123 C  CA  . GLU   A 1 303 ? 36.84372 -7.68645  -29.41006 1.000 53.22168  ? 837  GLU   A CA  1 
ATOM   2124 C  C   . GLU   A 1 303 ? 37.87810 -8.62848  -28.81199 1.000 52.76943  ? 837  GLU   A C   1 
ATOM   2125 O  O   . GLU   A 1 303 ? 38.85708 -8.96230  -29.48832 1.000 50.44124  ? 837  GLU   A O   1 
ATOM   2126 C  CB  . GLU   A 1 303 ? 37.38418 -6.25433  -29.38681 1.000 58.75938  ? 837  GLU   A CB  1 
ATOM   2127 C  CG  . GLU   A 1 303 ? 37.78799 -5.75521  -28.00660 1.000 62.13540  ? 837  GLU   A CG  1 
ATOM   2128 C  CD  . GLU   A 1 303 ? 36.85135 -4.68542  -27.47546 1.000 74.53090  ? 837  GLU   A CD  1 
ATOM   2129 O  OE1 . GLU   A 1 303 ? 35.87395 -4.34739  -28.17545 1.000 74.99524  ? 837  GLU   A OE1 1 
ATOM   2130 O  OE2 . GLU   A 1 303 ? 37.09186 -4.18042  -26.35882 1.000 75.86334  ? 837  GLU   A OE2 1 
ATOM   2131 N  N   . ASP   A 1 304 ? 37.68873 -9.06247  -27.56631 1.000 49.24584  ? 838  ASP   A N   1 
ATOM   2132 C  CA  . ASP   A 1 304 ? 38.65247 -9.93786  -26.91397 1.000 48.21197  ? 838  ASP   A CA  1 
ATOM   2133 C  C   . ASP   A 1 304 ? 38.53805 -11.39096 -27.35882 1.000 47.75518  ? 838  ASP   A C   1 
ATOM   2134 O  O   . ASP   A 1 304 ? 39.37750 -12.20700 -26.96396 1.000 49.23711  ? 838  ASP   A O   1 
ATOM   2135 C  CB  . ASP   A 1 304 ? 38.50045 -9.83584  -25.39448 1.000 53.73411  ? 838  ASP   A CB  1 
ATOM   2136 C  CG  . ASP   A 1 304 ? 38.64532 -8.41071  -24.89257 1.000 53.29788  ? 838  ASP   A CG  1 
ATOM   2137 O  OD1 . ASP   A 1 304 ? 39.65917 -7.76457  -25.23025 1.000 60.91409  ? 838  ASP   A OD1 1 
ATOM   2138 O  OD2 . ASP   A 1 304 ? 37.74316 -7.92908  -24.17590 1.000 52.38527  ? 838  ASP   A OD2 1 
ATOM   2139 N  N   . CYS   A 1 305 ? 37.53184 -11.73405 -28.16375 1.000 48.43785  ? 839  CYS   A N   1 
ATOM   2140 C  CA  . CYS   A 1 305 ? 37.47515 -13.03267 -28.82468 1.000 43.95190  ? 839  CYS   A CA  1 
ATOM   2141 C  C   . CYS   A 1 305 ? 38.27539 -13.05603 -30.12181 1.000 45.80134  ? 839  CYS   A C   1 
ATOM   2142 O  O   . CYS   A 1 305 ? 38.14558 -14.00404 -30.90446 1.000 41.21896  ? 839  CYS   A O   1 
ATOM   2143 C  CB  . CYS   A 1 305 ? 36.02172 -13.42710 -29.09813 1.000 46.65425  ? 839  CYS   A CB  1 
ATOM   2144 S  SG  . CYS   A 1 305 ? 35.09146 -13.88791 -27.61999 1.000 41.89409  ? 839  CYS   A SG  1 
ATOM   2145 N  N   . PHE   A 1 306 ? 39.08963 -12.02671 -30.35283 1.000 50.83786  ? 840  PHE   A N   1 
ATOM   2146 C  CA  . PHE   A 1 306 ? 39.91019 -11.96453 -31.55889 1.000 42.71443  ? 840  PHE   A CA  1 
ATOM   2147 C  C   . PHE   A 1 306 ? 40.88966 -13.12608 -31.71470 1.000 43.85879  ? 840  PHE   A C   1 
ATOM   2148 O  O   . PHE   A 1 306 ? 41.09705 -13.55898 -32.86248 1.000 38.79328  ? 840  PHE   A O   1 
ATOM   2149 C  CB  . PHE   A 1 306 ? 40.65221 -10.62142 -31.59017 1.000 38.80100  ? 840  PHE   A CB  1 
ATOM   2150 C  CG  . PHE   A 1 306 ? 41.63877 -10.49644 -32.71384 1.000 42.57684  ? 840  PHE   A CG  1 
ATOM   2151 C  CD1 . PHE   A 1 306 ? 41.21008 -10.24042 -34.00692 1.000 43.67641  ? 840  PHE   A CD1 1 
ATOM   2152 C  CD2 . PHE   A 1 306 ? 42.99703 -10.62983 -32.47632 1.000 44.41158  ? 840  PHE   A CD2 1 
ATOM   2153 C  CE1 . PHE   A 1 306 ? 42.11784 -10.12236 -35.04327 1.000 37.58178  ? 840  PHE   A CE1 1 
ATOM   2154 C  CE2 . PHE   A 1 306 ? 43.90924 -10.51431 -33.50650 1.000 48.22936  ? 840  PHE   A CE2 1 
ATOM   2155 C  CZ  . PHE   A 1 306 ? 43.46976 -10.25993 -34.79201 1.000 47.05075  ? 840  PHE   A CZ  1 
ATOM   2156 N  N   . PRO   A 1 307 ? 41.52920 -13.65758 -30.66005 1.000 39.76660  ? 841  PRO   A N   1 
ATOM   2157 C  CA  . PRO   A 1 307 ? 42.46286 -14.77673 -30.88025 1.000 39.47171  ? 841  PRO   A CA  1 
ATOM   2158 C  C   . PRO   A 1 307 ? 41.84922 -15.96577 -31.60333 1.000 40.51677  ? 841  PRO   A C   1 
ATOM   2159 O  O   . PRO   A 1 307 ? 42.57740 -16.70114 -32.28231 1.000 40.77596  ? 841  PRO   A O   1 
ATOM   2160 C  CB  . PRO   A 1 307 ? 42.90822 -15.14125 -29.45819 1.000 37.96440  ? 841  PRO   A CB  1 
ATOM   2161 C  CG  . PRO   A 1 307 ? 42.81160 -13.87116 -28.71728 1.000 39.23021  ? 841  PRO   A CG  1 
ATOM   2162 C  CD  . PRO   A 1 307 ? 41.58277 -13.19504 -29.25977 1.000 39.57287  ? 841  PRO   A CD  1 
ATOM   2163 N  N   . LEU   A 1 308 ? 40.53541 -16.17495 -31.49072 1.000 39.86537  ? 842  LEU   A N   1 
ATOM   2164 C  CA  . LEU   A 1 308 ? 39.88651 -17.22561 -32.26935 1.000 39.25865  ? 842  LEU   A CA  1 
ATOM   2165 C  C   . LEU   A 1 308 ? 39.90551 -16.89199 -33.75606 1.000 37.08359  ? 842  LEU   A C   1 
ATOM   2166 O  O   . LEU   A 1 308 ? 40.26896 -17.73179 -34.58804 1.000 35.51492  ? 842  LEU   A O   1 
ATOM   2167 C  CB  . LEU   A 1 308 ? 38.45335 -17.43080 -31.78009 1.000 37.96712  ? 842  LEU   A CB  1 
ATOM   2168 C  CG  . LEU   A 1 308 ? 38.30058 -18.01440 -30.37566 1.000 36.86976  ? 842  LEU   A CG  1 
ATOM   2169 C  CD1 . LEU   A 1 308 ? 36.88064 -17.81629 -29.87678 1.000 38.57169  ? 842  LEU   A CD1 1 
ATOM   2170 C  CD2 . LEU   A 1 308 ? 38.67914 -19.48517 -30.36385 1.000 35.56065  ? 842  LEU   A CD2 1 
ATOM   2171 N  N   . LEU   A 1 309 ? 39.51739 -15.66346 -34.10665 1.000 40.26446  ? 843  LEU   A N   1 
ATOM   2172 C  CA  . LEU   A 1 309 ? 39.57411 -15.23353 -35.50001 1.000 37.43249  ? 843  LEU   A CA  1 
ATOM   2173 C  C   . LEU   A 1 309 ? 41.00812 -15.22436 -36.01647 1.000 37.60550  ? 843  LEU   A C   1 
ATOM   2174 O  O   . LEU   A 1 309 ? 41.26195 -15.57707 -37.17478 1.000 36.05710  ? 843  LEU   A O   1 
ATOM   2175 C  CB  . LEU   A 1 309 ? 38.93975 -13.84886 -35.64316 1.000 37.03036  ? 843  LEU   A CB  1 
ATOM   2176 C  CG  . LEU   A 1 309 ? 39.08107 -13.15108 -36.99846 1.000 38.41834  ? 843  LEU   A CG  1 
ATOM   2177 C  CD1 . LEU   A 1 309 ? 38.48689 -13.99804 -38.11656 1.000 40.55562  ? 843  LEU   A CD1 1 
ATOM   2178 C  CD2 . LEU   A 1 309 ? 38.44749 -11.76615 -36.96903 1.000 42.31502  ? 843  LEU   A CD2 1 
ATOM   2179 N  N   . ASP   A 1 310 ? 41.96046 -14.83303 -35.16710 1.000 41.39280  ? 844  ASP   A N   1 
ATOM   2180 C  CA  . ASP   A 1 310 ? 43.36008 -14.78424 -35.57881 1.000 36.52134  ? 844  ASP   A CA  1 
ATOM   2181 C  C   . ASP   A 1 310 ? 43.89466 -16.17971 -35.87696 1.000 41.07719  ? 844  ASP   A C   1 
ATOM   2182 O  O   . ASP   A 1 310 ? 44.38860 -16.44855 -36.97829 1.000 42.92864  ? 844  ASP   A O   1 
ATOM   2183 C  CB  . ASP   A 1 310 ? 44.20095 -14.10571 -34.49582 1.000 42.20836  ? 844  ASP   A CB  1 
ATOM   2184 C  CG  . ASP   A 1 310 ? 45.49469 -13.52481 -35.03791 1.000 44.59032  ? 844  ASP   A CG  1 
ATOM   2185 O  OD1 . ASP   A 1 310 ? 45.52823 -13.14332 -36.22686 1.000 42.61250  ? 844  ASP   A OD1 1 
ATOM   2186 O  OD2 . ASP   A 1 310 ? 46.47835 -13.44933 -34.27273 1.000 46.19002  ? 844  ASP   A OD2 1 
ATOM   2187 N  N   . GLY   A 1 311 ? 43.81013 -17.08331 -34.89587 1.000 37.35303  ? 845  GLY   A N   1 
ATOM   2188 C  CA  . GLY   A 1 311 ? 44.30457 -18.43473 -35.09927 1.000 38.89375  ? 845  GLY   A CA  1 
ATOM   2189 C  C   . GLY   A 1 311 ? 43.61276 -19.15918 -36.23625 1.000 37.27903  ? 845  GLY   A C   1 
ATOM   2190 O  O   . GLY   A 1 311 ? 44.20041 -20.04678 -36.86098 1.000 43.77713  ? 845  GLY   A O   1 
ATOM   2191 N  N   . CYS   A 1 312 ? 42.35931 -18.79600 -36.52092 1.000 38.81919  ? 846  CYS   A N   1 
ATOM   2192 C  CA  . CYS   A 1 312 ? 41.65952 -19.38713 -37.65518 1.000 38.32984  ? 846  CYS   A CA  1 
ATOM   2193 C  C   . CYS   A 1 312 ? 42.21975 -18.87898 -38.97817 1.000 40.58817  ? 846  CYS   A C   1 
ATOM   2194 O  O   . CYS   A 1 312 ? 42.19813 -19.60476 -39.97844 1.000 40.00690  ? 846  CYS   A O   1 
ATOM   2195 C  CB  . CYS   A 1 312 ? 40.15921 -19.10079 -37.55241 1.000 36.85880  ? 846  CYS   A CB  1 
ATOM   2196 S  SG  . CYS   A 1 312 ? 39.17540 -19.68887 -38.94976 1.000 38.93754  ? 846  CYS   A SG  1 
ATOM   2197 N  N   . ARG   A 1 313 ? 42.74098 -17.65001 -39.00057 1.000 42.27299  ? 847  ARG   A N   1 
ATOM   2198 C  CA  . ARG   A 1 313 ? 43.33900 -17.11634 -40.21987 1.000 36.47430  ? 847  ARG   A CA  1 
ATOM   2199 C  C   . ARG   A 1 313 ? 44.73657 -17.67693 -40.44695 1.000 41.75552  ? 847  ARG   A C   1 
ATOM   2200 O  O   . ARG   A 1 313 ? 45.09642 -18.01673 -41.58018 1.000 45.57035  ? 847  ARG   A O   1 
ATOM   2201 C  CB  . ARG   A 1 313 ? 43.38832 -15.59032 -40.15890 1.000 33.12759  ? 847  ARG   A CB  1 
ATOM   2202 C  CG  . ARG   A 1 313 ? 42.04114 -14.91126 -40.32165 1.000 38.10964  ? 847  ARG   A CG  1 
ATOM   2203 C  CD  . ARG   A 1 313 ? 42.11833 -13.44998 -39.91920 1.000 37.10639  ? 847  ARG   A CD  1 
ATOM   2204 N  NE  . ARG   A 1 313 ? 40.91057 -12.72016 -40.28386 1.000 47.33994  ? 847  ARG   A NE  1 
ATOM   2205 C  CZ  . ARG   A 1 313 ? 40.63962 -11.48192 -39.89546 1.000 50.51992  ? 847  ARG   A CZ  1 
ATOM   2206 N  NH1 . ARG   A 1 313 ? 41.47378 -10.80132 -39.12602 1.000 46.13629  ? 847  ARG   A NH1 1 
ATOM   2207 N  NH2 . ARG   A 1 313 ? 39.50315 -10.91277 -40.28809 1.000 47.06577  ? 847  ARG   A NH2 1 
ATOM   2208 N  N   . LYS   A 1 314 ? 45.53580 -17.77289 -39.38119 1.000 41.89037  ? 848  LYS   A N   1 
ATOM   2209 C  CA  . LYS   A 1 314 ? 46.87441 -18.33768 -39.50347 1.000 40.83932  ? 848  LYS   A CA  1 
ATOM   2210 C  C   . LYS   A 1 314 ? 46.82375 -19.78860 -39.95799 1.000 41.70824  ? 848  LYS   A C   1 
ATOM   2211 O  O   . LYS   A 1 314 ? 47.74006 -20.25646 -40.64313 1.000 44.75763  ? 848  LYS   A O   1 
ATOM   2212 C  CB  . LYS   A 1 314 ? 47.61525 -18.21543 -38.17079 1.000 42.56238  ? 848  LYS   A CB  1 
ATOM   2213 C  CG  . LYS   A 1 314 ? 47.69509 -16.78957 -37.64723 1.000 43.87319  ? 848  LYS   A CG  1 
ATOM   2214 C  CD  . LYS   A 1 314 ? 48.62664 -16.67366 -36.45178 1.000 46.22170  ? 848  LYS   A CD  1 
ATOM   2215 C  CE  . LYS   A 1 314 ? 48.83857 -15.21851 -36.06273 1.000 46.10023  ? 848  LYS   A CE  1 
ATOM   2216 N  NZ  . LYS   A 1 314 ? 49.41255 -15.07662 -34.69646 1.000 42.84695  ? 848  LYS   A NZ  1 
ATOM   2217 N  N   . ASN   A 1 315 ? 45.76036 -20.51084 -39.59901 1.000 44.74405  ? 849  ASN   A N   1 
ATOM   2218 C  CA  . ASN   A 1 315 ? 45.60610 -21.88633 -40.05535 1.000 42.11915  ? 849  ASN   A CA  1 
ATOM   2219 C  C   . ASN   A 1 315 ? 45.12523 -21.95490 -41.49823 1.000 39.51171  ? 849  ASN   A C   1 
ATOM   2220 O  O   . ASN   A 1 315 ? 45.43695 -22.92032 -42.20474 1.000 39.39479  ? 849  ASN   A O   1 
ATOM   2221 C  CB  . ASN   A 1 315 ? 44.64268 -22.63747 -39.13720 1.000 43.14068  ? 849  ASN   A CB  1 
ATOM   2222 C  CG  . ASN   A 1 315 ? 45.31533 -23.13337 -37.87257 1.000 45.17156  ? 849  ASN   A CG  1 
ATOM   2223 O  OD1 . ASN   A 1 315 ? 46.54071 -23.23252 -37.80670 1.000 45.70581  ? 849  ASN   A OD1 1 
ATOM   2224 N  ND2 . ASN   A 1 315 ? 44.51705 -23.43371 -36.85514 1.000 40.76707  ? 849  ASN   A ND2 1 
ATOM   2225 N  N   . ARG   A 1 316 ? 44.36575 -20.95372 -41.95059 1.000 43.14289  ? 850  ARG   A N   1 
ATOM   2226 C  CA  . ARG   A 1 316 ? 44.02276 -20.88123 -43.36689 1.000 46.13514  ? 850  ARG   A CA  1 
ATOM   2227 C  C   . ARG   A 1 316 ? 45.26916 -20.66374 -44.21244 1.000 43.25811  ? 850  ARG   A C   1 
ATOM   2228 O  O   . ARG   A 1 316 ? 45.42379 -21.27572 -45.27569 1.000 44.93084  ? 850  ARG   A O   1 
ATOM   2229 C  CB  . ARG   A 1 316 ? 43.00906 -19.76345 -43.61668 1.000 41.32864  ? 850  ARG   A CB  1 
ATOM   2230 C  CG  . ARG   A 1 316 ? 42.14783 -19.98237 -44.85162 1.000 41.55432  ? 850  ARG   A CG  1 
ATOM   2231 C  CD  . ARG   A 1 316 ? 41.83160 -18.67308 -45.56797 1.000 42.04531  ? 850  ARG   A CD  1 
ATOM   2232 N  NE  . ARG   A 1 316 ? 41.04315 -18.88927 -46.77664 1.000 39.95771  ? 850  ARG   A NE  1 
ATOM   2233 C  CZ  . ARG   A 1 316 ? 41.55143 -19.01250 -47.99595 1.000 40.23904  ? 850  ARG   A CZ  1 
ATOM   2234 N  NH1 . ARG   A 1 316 ? 42.85466 -18.94112 -48.21323 1.000 36.10323  ? 850  ARG   A NH1 1 
ATOM   2235 N  NH2 . ARG   A 1 316 ? 40.73105 -19.21300 -49.02375 1.000 39.95328  ? 850  ARG   A NH2 1 
ATOM   2236 N  N   . GLN   A 1 317 ? 46.17201 -19.79550 -43.74988 1.000 42.73567  ? 851  GLN   A N   1 
ATOM   2237 C  CA  . GLN   A 1 317 ? 47.43577 -19.58393 -44.44888 1.000 43.95863  ? 851  GLN   A CA  1 
ATOM   2238 C  C   . GLN   A 1 317 ? 48.24684 -20.87153 -44.51927 1.000 43.33288  ? 851  GLN   A C   1 
ATOM   2239 O  O   . GLN   A 1 317 ? 48.81431 -21.20543 -45.56575 1.000 45.48221  ? 851  GLN   A O   1 
ATOM   2240 C  CB  . GLN   A 1 317 ? 48.23573 -18.47855 -43.75517 1.000 41.45470  ? 851  GLN   A CB  1 
ATOM   2241 C  CG  . GLN   A 1 317 ? 49.44997 -17.98000 -44.53255 1.000 44.74994  ? 851  GLN   A CG  1 
ATOM   2242 C  CD  . GLN   A 1 317 ? 50.68167 -18.84537 -44.31715 1.000 53.61850  ? 851  GLN   A CD  1 
ATOM   2243 O  OE1 . GLN   A 1 317 ? 51.05330 -19.14117 -43.18170 1.000 59.29345  ? 851  GLN   A OE1 1 
ATOM   2244 N  NE2 . GLN   A 1 317 ? 51.32288 -19.24949 -45.40789 1.000 52.58187  ? 851  GLN   A NE2 1 
ATOM   2245 N  N   . LYS   A 1 318 ? 48.30799 -21.61273 -43.41129 1.000 41.67359  ? 852  LYS   A N   1 
ATOM   2246 C  CA  . LYS   A 1 318 ? 49.12282 -22.82251 -43.37950 1.000 35.88643  ? 852  LYS   A CA  1 
ATOM   2247 C  C   . LYS   A 1 318 ? 48.53592 -23.91183 -44.26949 1.000 39.26690  ? 852  LYS   A C   1 
ATOM   2248 O  O   . LYS   A 1 318 ? 49.27152 -24.58301 -45.00291 1.000 43.50876  ? 852  LYS   A O   1 
ATOM   2249 C  CB  . LYS   A 1 318 ? 49.26602 -23.31893 -41.94133 1.000 37.22337  ? 852  LYS   A CB  1 
ATOM   2250 C  CG  . LYS   A 1 318 ? 50.11210 -22.42356 -41.04926 1.000 39.97558  ? 852  LYS   A CG  1 
ATOM   2251 C  CD  . LYS   A 1 318 ? 51.59678 -22.63994 -41.28403 1.000 42.76005  ? 852  LYS   A CD  1 
ATOM   2252 C  CE  . LYS   A 1 318 ? 52.43603 -21.72192 -40.40962 1.000 42.25241  ? 852  LYS   A CE  1 
ATOM   2253 N  NZ  . LYS   A 1 318 ? 53.80354 -21.55491 -40.97178 1.000 41.98900  ? 852  LYS   A NZ  1 
ATOM   2254 N  N   . TRP   A 1 319 ? 47.21428 -24.10367 -44.21986 1.000 42.88918  ? 853  TRP   A N   1 
ATOM   2255 C  CA  . TRP   A 1 319 ? 46.58718 -25.11786 -45.06106 1.000 39.48029  ? 853  TRP   A CA  1 
ATOM   2256 C  C   . TRP   A 1 319 ? 46.59906 -24.71480 -46.53133 1.000 42.71696  ? 853  TRP   A C   1 
ATOM   2257 O  O   . TRP   A 1 319 ? 46.71029 -25.58054 -47.40712 1.000 42.96938  ? 853  TRP   A O   1 
ATOM   2258 C  CB  . TRP   A 1 319 ? 45.15447 -25.38403 -44.59775 1.000 37.23931  ? 853  TRP   A CB  1 
ATOM   2259 C  CG  . TRP   A 1 319 ? 45.03865 -26.23490 -43.36277 1.000 38.74267  ? 853  TRP   A CG  1 
ATOM   2260 C  CD1 . TRP   A 1 319 ? 44.36066 -25.92486 -42.21990 1.000 42.03095  ? 853  TRP   A CD1 1 
ATOM   2261 C  CD2 . TRP   A 1 319 ? 45.60185 -27.53812 -43.15250 1.000 43.82868  ? 853  TRP   A CD2 1 
ATOM   2262 N  NE1 . TRP   A 1 319 ? 44.47231 -26.94794 -41.30934 1.000 42.60470  ? 853  TRP   A NE1 1 
ATOM   2263 C  CE2 . TRP   A 1 319 ? 45.22861 -27.94988 -41.85766 1.000 43.17781  ? 853  TRP   A CE2 1 
ATOM   2264 C  CE3 . TRP   A 1 319 ? 46.38781 -28.39404 -43.93076 1.000 42.86692  ? 853  TRP   A CE3 1 
ATOM   2265 C  CZ2 . TRP   A 1 319 ? 45.61390 -29.17812 -41.32456 1.000 43.10280  ? 853  TRP   A CZ2 1 
ATOM   2266 C  CZ3 . TRP   A 1 319 ? 46.76882 -29.61402 -43.39896 1.000 46.46674  ? 853  TRP   A CZ3 1 
ATOM   2267 C  CH2 . TRP   A 1 319 ? 46.38165 -29.99375 -42.10893 1.000 48.59732  ? 853  TRP   A CH2 1 
ATOM   2268 N  N   . GLN   A 1 320 ? 46.48718 -23.41449 -46.82180 1.000 48.03854  ? 854  GLN   A N   1 
ATOM   2269 C  CA  . GLN   A 1 320 ? 46.53008 -22.95157 -48.20757 1.000 48.29371  ? 854  GLN   A CA  1 
ATOM   2270 C  C   . GLN   A 1 320 ? 47.90552 -23.17502 -48.82589 1.000 45.68743  ? 854  GLN   A C   1 
ATOM   2271 O  O   . GLN   A 1 320 ? 48.01107 -23.55083 -49.99987 1.000 45.28390  ? 854  GLN   A O   1 
ATOM   2272 C  CB  . GLN   A 1 320 ? 46.14219 -21.47174 -48.27669 1.000 44.53847  ? 854  GLN   A CB  1 
ATOM   2273 C  CG  . GLN   A 1 320 ? 46.10783 -20.86024 -49.67734 1.000 45.39950  ? 854  GLN   A CG  1 
ATOM   2274 C  CD  . GLN   A 1 320 ? 45.34261 -21.69133 -50.70439 1.000 46.45526  ? 854  GLN   A CD  1 
ATOM   2275 O  OE1 . GLN   A 1 320 ? 44.41218 -22.43142 -50.37436 1.000 43.41320  ? 854  GLN   A OE1 1 
ATOM   2276 N  NE2 . GLN   A 1 320 ? 45.74042 -21.56664 -51.96331 1.000 49.55865  ? 854  GLN   A NE2 1 
ATOM   2277 N  N   . ALA   A 1 321 ? 48.97112 -22.93958 -48.05549 1.000 45.71266  ? 855  ALA   A N   1 
ATOM   2278 C  CA  . ALA   A 1 321 ? 50.31418 -23.21133 -48.55597 1.000 44.14015  ? 855  ALA   A CA  1 
ATOM   2279 C  C   . ALA   A 1 321 ? 50.51013 -24.70122 -48.80138 1.000 49.45507  ? 855  ALA   A C   1 
ATOM   2280 O  O   . ALA   A 1 321 ? 51.09193 -25.10224 -49.81688 1.000 56.63471  ? 855  ALA   A O   1 
ATOM   2281 C  CB  . ALA   A 1 321 ? 51.35924 -22.68205 -47.57435 1.000 44.71136  ? 855  ALA   A CB  1 
ATOM   2282 N  N   . LEU   A 1 322 ? 50.01474 -25.53832 -47.88685 1.000 48.12192  ? 856  LEU   A N   1 
ATOM   2283 C  CA  . LEU   A 1 322 ? 50.09182 -26.98240 -48.08370 1.000 48.22445  ? 856  LEU   A CA  1 
ATOM   2284 C  C   . LEU   A 1 322 ? 49.28158 -27.42003 -49.29893 1.000 53.56854  ? 856  LEU   A C   1 
ATOM   2285 O  O   . LEU   A 1 322 ? 49.68694 -28.33284 -50.02998 1.000 52.48146  ? 856  LEU   A O   1 
ATOM   2286 C  CB  . LEU   A 1 322 ? 49.60576 -27.70669 -46.82758 1.000 48.52897  ? 856  LEU   A CB  1 
ATOM   2287 C  CG  . LEU   A 1 322 ? 50.66102 -28.28412 -45.88191 1.000 53.33601  ? 856  LEU   A CG  1 
ATOM   2288 C  CD1 . LEU   A 1 322 ? 50.08008 -28.49652 -44.49090 1.000 48.43812  ? 856  LEU   A CD1 1 
ATOM   2289 C  CD2 . LEU   A 1 322 ? 51.22599 -29.58494 -46.43094 1.000 52.87036  ? 856  LEU   A CD2 1 
ATOM   2290 N  N   . ALA   A 1 323 ? 48.13223 -26.77787 -49.52960 1.000 54.13329  ? 857  ALA   A N   1 
ATOM   2291 C  CA  . ALA   A 1 323 ? 47.29720 -27.13097 -50.67347 1.000 53.89957  ? 857  ALA   A CA  1 
ATOM   2292 C  C   . ALA   A 1 323 ? 48.04194 -26.91996 -51.98593 1.000 61.26614  ? 857  ALA   A C   1 
ATOM   2293 O  O   . ALA   A 1 323 ? 47.94492 -27.74279 -52.90401 1.000 65.84882  ? 857  ALA   A O   1 
ATOM   2294 C  CB  . ALA   A 1 323 ? 46.00203 -26.31805 -50.64767 1.000 49.89479  ? 857  ALA   A CB  1 
ATOM   2295 N  N   . GLU   A 1 324 ? 48.80791 -25.83782 -52.08439 1.000 58.63363  ? 858  GLU   A N   1 
ATOM   2296 C  CA  . GLU   A 1 324 ? 49.62507 -25.52980 -53.25638 1.000 61.47715  ? 858  GLU   A CA  1 
ATOM   2297 C  C   . GLU   A 1 324 ? 50.88293 -26.38234 -53.34982 1.000 66.07815  ? 858  GLU   A C   1 
ATOM   2298 O  O   . GLU   A 1 324 ? 51.74267 -26.06071 -54.18249 1.000 70.61017  ? 858  GLU   A O   1 
ATOM   2299 C  CB  . GLU   A 1 324 ? 50.01525 -24.05082 -53.24015 1.000 50.78388  ? 858  GLU   A CB  1 
ATOM   2300 C  CG  . GLU   A 1 324 ? 48.84993 -23.08781 -53.33652 1.000 48.20125  ? 858  GLU   A CG  1 
ATOM   2301 C  CD  . GLU   A 1 324 ? 49.21566 -21.69948 -52.85276 1.000 53.64876  ? 858  GLU   A CD  1 
ATOM   2302 O  OE1 . GLU   A 1 324 ? 50.21438 -21.56871 -52.11245 1.000 56.43395  ? 858  GLU   A OE1 1 
ATOM   2303 O  OE2 . GLU   A 1 324 ? 48.49562 -20.74094 -53.20089 1.000 55.13392  ? 858  GLU   A OE2 1 
ATOM   2304 N  N   . GLN   A 1 325 ? 50.99285 -27.42817 -52.53569 1.000 66.42798  ? 859  GLN   A N   1 
ATOM   2305 C  CA  . GLN   A 1 325 ? 52.20791 -28.23800 -52.42660 1.000 65.66529  ? 859  GLN   A CA  1 
ATOM   2306 C  C   . GLN   A 1 325 ? 53.40237 -27.39050 -52.00124 1.000 62.80092  ? 859  GLN   A C   1 
ATOM   2307 O  O   . GLN   A 1 325 ? 54.08510 -27.71063 -51.02823 1.000 64.12434  ? 859  GLN   A O   1 
ATOM   2308 C  CB  . GLN   A 1 325 ? 52.52204 -28.95352 -53.74348 1.000 69.04212  ? 859  GLN   A CB  1 
ATOM   2309 C  CG  . GLN   A 1 325 ? 51.84899 -30.30485 -53.90557 1.000 72.40962  ? 859  GLN   A CG  1 
ATOM   2310 C  CD  . GLN   A 1 325 ? 50.62110 -30.23693 -54.79220 1.000 81.39611  ? 859  GLN   A CD  1 
ATOM   2311 O  OE1 . GLN   A 1 325 ? 50.69103 -29.78113 -55.93410 1.000 76.63918  ? 859  GLN   A OE1 1 
ATOM   2312 N  NE2 . GLN   A 1 325 ? 49.48931 -30.69487 -54.27271 1.000 80.97303  ? 859  GLN   A NE2 1 
HETATM 2313 C  C13 . A1ELJ B 2 .   ? 34.85705 -30.98540 -41.10956 1.000 48.88663  ? 901  A1ELJ A C13 1 
HETATM 2314 C  C15 . A1ELJ B 2 .   ? 35.44560 -30.79624 -43.50917 1.000 44.22947  ? 901  A1ELJ A C15 1 
HETATM 2315 C  C17 . A1ELJ B 2 .   ? 37.62741 -32.12449 -43.38643 1.000 43.38034  ? 901  A1ELJ A C17 1 
HETATM 2316 C  C20 . A1ELJ B 2 .   ? 38.88201 -34.59703 -43.76123 1.000 48.80656  ? 901  A1ELJ A C20 1 
HETATM 2317 C  C22 . A1ELJ B 2 .   ? 39.41395 -33.64956 -42.89341 1.000 45.49250  ? 901  A1ELJ A C22 1 
HETATM 2318 C  C11 . A1ELJ B 2 .   ? 36.36340 -30.01913 -39.46678 1.000 43.07585  ? 901  A1ELJ A C11 1 
HETATM 2319 C  C12 . A1ELJ B 2 .   ? 36.12073 -30.48536 -40.79090 1.000 46.03694  ? 901  A1ELJ A C12 1 
HETATM 2320 C  C18 . A1ELJ B 2 .   ? 37.10673 -33.06264 -44.26902 1.000 48.48578  ? 901  A1ELJ A C18 1 
HETATM 2321 C  C19 . A1ELJ B 2 .   ? 37.72094 -34.29028 -44.45811 1.000 46.99563  ? 901  A1ELJ A C19 1 
HETATM 2322 C  C23 . A1ELJ B 2 .   ? 38.79444 -32.43154 -42.70103 1.000 43.65930  ? 901  A1ELJ A C23 1 
HETATM 2323 C  C1  . A1ELJ B 2 .   ? 32.82871 -32.52211 -43.84143 1.000 49.11600  ? 901  A1ELJ A C1  1 
HETATM 2324 C  C10 . A1ELJ B 2 .   ? 37.61569 -29.55393 -39.01371 1.000 43.49193  ? 901  A1ELJ A C10 1 
HETATM 2325 C  C14 . A1ELJ B 2 .   ? 34.62450 -31.58099 -42.48309 1.000 45.60896  ? 901  A1ELJ A C14 1 
HETATM 2326 C  C16 . A1ELJ B 2 .   ? 36.94340 -30.78848 -43.16232 1.000 45.44745  ? 901  A1ELJ A C16 1 
HETATM 2327 C  C2  . A1ELJ B 2 .   ? 32.21926 -31.01237 -41.98026 1.000 46.98353  ? 901  A1ELJ A C2  1 
HETATM 2328 C  C21 . A1ELJ B 2 .   ? 38.89328 -36.84738 -44.54761 1.000 62.55556  ? 901  A1ELJ A C21 1 
HETATM 2329 C  C3  . A1ELJ B 2 .   ? 32.45828 -31.33436 -40.51830 1.000 44.85747  ? 901  A1ELJ A C3  1 
HETATM 2330 C  C4  . A1ELJ B 2 .   ? 33.85855 -30.95249 -40.14435 1.000 47.30775  ? 901  A1ELJ A C4  1 
HETATM 2331 C  C5  . A1ELJ B 2 .   ? 35.28346 -30.06174 -38.55453 1.000 45.84806  ? 901  A1ELJ A C5  1 
HETATM 2332 C  C6  . A1ELJ B 2 .   ? 35.49345 -29.63132 -37.22209 1.000 42.22695  ? 901  A1ELJ A C6  1 
HETATM 2333 C  C7  . A1ELJ B 2 .   ? 36.72334 -29.18746 -36.81456 1.000 41.24194  ? 901  A1ELJ A C7  1 
HETATM 2334 C  C8  . A1ELJ B 2 .   ? 37.79380 -29.15003 -37.70822 1.000 44.26218  ? 901  A1ELJ A C8  1 
HETATM 2335 C  C9  . A1ELJ B 2 .   ? 39.09812 -28.71019 -37.27241 1.000 37.65761  ? 901  A1ELJ A C9  1 
HETATM 2336 N  N1  . A1ELJ B 2 .   ? 34.03746 -30.52252 -38.90614 1.000 47.68239  ? 901  A1ELJ A N1  1 
HETATM 2337 N  N2  . A1ELJ B 2 .   ? 40.14125 -28.36859 -36.95604 1.000 35.16032  ? 901  A1ELJ A N2  1 
HETATM 2338 N  N3  . A1ELJ B 2 .   ? 37.09184 -30.37728 -41.76879 1.000 45.70545  ? 901  A1ELJ A N3  1 
HETATM 2339 O  O1  . A1ELJ B 2 .   ? 33.63358 -33.28821 -44.35015 1.000 52.22152  ? 901  A1ELJ A O1  1 
HETATM 2340 N  N   . A1ELJ B 2 .   ? 33.19570 -31.72729 -42.81089 1.000 44.99713  ? 901  A1ELJ A N   1 
HETATM 2341 C  C   . A1ELJ B 2 .   ? 31.41166 -32.43400 -44.32042 1.000 52.81636  ? 901  A1ELJ A C   1 
HETATM 2342 O  O   . A1ELJ B 2 .   ? 39.53977 -35.79116 -43.84374 1.000 54.03698  ? 901  A1ELJ A O   1 
HETATM 2343 CL CL  . A1ELJ B 2 .   ? 40.89677 -33.98601 -42.06054 1.000 48.78562  ? 901  A1ELJ A CL  1 
HETATM 2344 ZN ZN  . ZN    C 3 .   ? 31.00805 -31.34155 -31.57353 1.000 42.47685  ? 902  ZN    A ZN  1 
HETATM 2345 MG MG  . MG    D 4 .   ? 27.98853 -32.68922 -33.15467 1.000 35.48561  ? 903  MG    A MG  1 
HETATM 2346 O  O   . HOH   E 5 .   ? 26.53447 -31.86407 -34.42845 1.000 29.59454  ? 1001 HOH   A O   1 
HETATM 2347 O  O   . HOH   E 5 .   ? 15.73910 -7.57795  -42.76533 1.000 54.35912  ? 1002 HOH   A O   1 
HETATM 2348 O  O   . HOH   E 5 .   ? 17.45023 -36.47181 -6.13114  1.000 34.90565  ? 1003 HOH   A O   1 
HETATM 2349 O  O   . HOH   E 5 .   ? 50.09705 -31.35712 -41.45804 1.000 41.78077  ? 1004 HOH   A O   1 
HETATM 2350 O  O   . HOH   E 5 .   ? 26.54920 -32.12013 -31.62807 1.000 26.49506  ? 1005 HOH   A O   1 
HETATM 2351 O  O   . HOH   E 5 .   ? 29.42642 -30.95230 -32.89963 1.000 36.30853  ? 1006 HOH   A O   1 
HETATM 2352 O  O   . HOH   E 5 .   ? 27.218   -10.907   -45.084   1.000 46.18882  ? 1007 HOH   A O   1 
HETATM 2353 O  O   . HOH   E 5 .   ? 35.80911 -47.02610 -10.98331 1.000 59.21113  ? 1008 HOH   A O   1 
HETATM 2354 O  O   . HOH   E 5 .   ? 33.98586 -30.07505 -33.89012 1.000 37.34432  ? 1009 HOH   A O   1 
HETATM 2355 O  O   . HOH   E 5 .   ? 44.49792 -11.85210 -38.31953 1.000 43.66337  ? 1010 HOH   A O   1 
HETATM 2356 O  O   . HOH   E 5 .   ? 31.95552 -31.81164 -33.86356 1.000 35.59834  ? 1011 HOH   A O   1 
HETATM 2357 O  O   . HOH   E 5 .   ? 39.01191 -35.35998 -29.61386 1.000 33.24155  ? 1012 HOH   A O   1 
HETATM 2358 O  O   . HOH   E 5 .   ? 45.32227 -33.23851 -4.46966  1.000 40.61485  ? 1013 HOH   A O   1 
HETATM 2359 O  O   . HOH   E 5 .   ? 25.22344 -32.53997 -37.41418 1.000 37.12336  ? 1014 HOH   A O   1 
HETATM 2360 O  O   . HOH   E 5 .   ? 26.57269 -34.38055 -33.22989 1.000 30.11046  ? 1015 HOH   A O   1 
HETATM 2361 O  O   . HOH   E 5 .   ? 32.79573 -18.10376 -43.25702 1.000 39.77421  ? 1016 HOH   A O   1 
HETATM 2362 O  O   . HOH   E 5 .   ? 24.69524 -34.45819 -18.52965 1.000 33.23316  ? 1017 HOH   A O   1 
HETATM 2363 O  O   . HOH   E 5 .   ? 43.18130 -20.95402 -30.36625 1.000 41.43229  ? 1018 HOH   A O   1 
HETATM 2364 O  O   . HOH   E 5 .   ? 20.63074 -32.18340 -12.33903 1.000 37.45663  ? 1019 HOH   A O   1 
HETATM 2365 O  O   . HOH   E 5 .   ? 49.13536 -24.75417 -27.05701 1.000 34.45617  ? 1020 HOH   A O   1 
HETATM 2366 O  O   . HOH   E 5 .   ? 13.60025 -18.96621 -14.85718 1.000 41.71654  ? 1021 HOH   A O   1 
HETATM 2367 O  O   . HOH   E 5 .   ? 31.87705 -21.78753 -7.45145  1.000 37.82506  ? 1022 HOH   A O   1 
HETATM 2368 O  O   . HOH   E 5 .   ? 22.10105 -33.50484 -6.02981  1.000 35.59945  ? 1023 HOH   A O   1 
HETATM 2369 O  O   . HOH   E 5 .   ? 29.52066 -33.50272 -34.26951 1.000 29.86616  ? 1024 HOH   A O   1 
HETATM 2370 O  O   . HOH   E 5 .   ? 24.69650 -41.91042 -15.58072 1.000 34.79359  ? 1025 HOH   A O   1 
HETATM 2371 O  O   . HOH   E 5 .   ? 44.28126 -30.02713 -28.09365 1.000 36.86766  ? 1026 HOH   A O   1 
HETATM 2372 O  O   . HOH   E 5 .   ? 28.83820 -44.32961 -24.52040 1.000 35.93426  ? 1027 HOH   A O   1 
HETATM 2373 O  O   . HOH   E 5 .   ? 47.07271 -24.27737 -8.47640  1.000 27.70925  ? 1028 HOH   A O   1 
HETATM 2374 O  O   . HOH   E 5 .   ? 51.53506 -33.48476 -37.59194 1.000 41.44338  ? 1029 HOH   A O   1 
HETATM 2375 O  O   . HOH   E 5 .   ? 31.33456 -28.52826 -3.91800  1.000 40.98796  ? 1030 HOH   A O   1 
HETATM 2376 O  O   . HOH   E 5 .   ? 39.81457 -27.47658 -29.25537 1.000 35.10435  ? 1031 HOH   A O   1 
HETATM 2377 O  O   . HOH   E 5 .   ? 48.64307 -17.78756 -25.45658 1.000 34.74609  ? 1032 HOH   A O   1 
HETATM 2378 O  O   . HOH   E 5 .   ? 33.87775 -4.62146  -30.66905 1.000 41.86943  ? 1033 HOH   A O   1 
HETATM 2379 O  O   . HOH   E 5 .   ? 22.38847 -13.96774 -13.11375 1.000 38.70919  ? 1034 HOH   A O   1 
HETATM 2380 O  O   . HOH   E 5 .   ? 45.76269 -12.84951 -31.12233 1.000 40.91346  ? 1035 HOH   A O   1 
HETATM 2381 O  O   . HOH   E 5 .   ? 45.73783 -19.57526 -17.81042 1.000 40.15234  ? 1036 HOH   A O   1 
HETATM 2382 O  O   . HOH   E 5 .   ? 22.94052 -41.36583 -37.84011 1.000 41.53249  ? 1037 HOH   A O   1 
HETATM 2383 O  O   . HOH   E 5 .   ? 17.49042 -17.89225 -33.57942 1.000 47.74171  ? 1038 HOH   A O   1 
HETATM 2384 O  O   . HOH   E 5 .   ? 50.61149 -19.84444 -33.20247 1.000 36.67293  ? 1039 HOH   A O   1 
# 
