data_9LO7
# 
_entry.id   9LO7 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9LO7         pdb_00009lo7 10.2210/pdb9lo7/pdb 
WWPDB D_1300056100 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-03-26 ? 
2 'Structure model' 1 1 2025-04-09 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation_author.identifier_ORCID' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9LO7 
_pdbx_database_status.recvd_initial_deposition_date   2025-01-22 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              hbluo@hainanu.edu.cn 
_pdbx_contact_author.name_first         Hai-Bin 
_pdbx_contact_author.name_last          Luo 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-2163-0509 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Huag, Y.-Y.' 1 ? 
'Wu, D.'      2 ? 
'Luo, H.-B.'  3 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            J.Med.Chem. 
_citation.journal_id_ASTM           JMCMAR 
_citation.journal_id_CSD            0151 
_citation.journal_id_ISSN           0022-2623 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            68 
_citation.language                  ? 
_citation.page_first                6789 
_citation.page_last                 6803 
_citation.title                     
'Structure-Based Optimization of Moracin M as Potent and Selective PDE4 Inhibitors with Antipsoriasis Effects.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acs.jmedchem.5c00266 
_citation.pdbx_database_id_PubMed   40066994 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zhang, F.'   1  ? 
primary 'Zheng, T.'   2  ? 
primary 'Wang, X.'    3  ? 
primary 'Chen, Y.'    4  ? 
primary 'Zhang, F.'   5  ? 
primary 'Liu, X.'     6  ? 
primary 'Wang, S.'    7  ? 
primary 'Yang, G.'    8  ? 
primary 'Xie, S.'     9  ? 
primary 'Wu, Q.'      10 ? 
primary 'Xu, C.'      11 ? 
primary 'Zhou, Q.'    12 ? 
primary 'Wu, D.'      13 ? 
primary 'Luo, H.B.'   14 ? 
primary 'Huang, Y.Y.' 15 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 
;3',5'-cyclic-AMP phosphodiesterase 4D
;
57758.402 2   3.1.4.53 ? ? ? 
2 non-polymer syn 'ZINC ION' 65.409    2   ?        ? ? ? 
3 non-polymer syn 'MAGNESIUM ION' 24.305    2   ?        ? ? ? 
4 non-polymer syn 
;methyl 4-[[2-[4-[bis(fluoranyl)methoxy]-3-(cyclopropen-1-ylmethoxy)phenyl]-6-oxidanyl-1-benzofuran-7-yl]oxy]-1~{H}-pyrrole-2-carboxylate
;
483.418   2   ?        ? ? ? 
5 water       nat water 18.015    279 ?        ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'DPDE3,PDE43,cAMP-specific phosphodiesterase 4D' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIP
RFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYH
NNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKL
LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLS
NPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLE
DNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDE
QVEEEAVGEEEESQPEACVIDDRSPD
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIP
RFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYH
NNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKL
LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLS
NPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLE
DNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDE
QVEEEAVGEEEESQPEACVIDDRSPD
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION' ZN    
3 'MAGNESIUM ION' MG    
4 
;methyl 4-[[2-[4-[bis(fluoranyl)methoxy]-3-(cyclopropen-1-ylmethoxy)phenyl]-6-oxidanyl-1-benzofuran-7-yl]oxy]-1~{H}-pyrrole-2-carboxylate
;
A1EKX 
5 water HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   SER n 
1 4   ASN n 
1 5   LYS n 
1 6   PHE n 
1 7   LYS n 
1 8   ARG n 
1 9   MET n 
1 10  LEU n 
1 11  ASN n 
1 12  ARG n 
1 13  GLU n 
1 14  LEU n 
1 15  THR n 
1 16  HIS n 
1 17  LEU n 
1 18  SER n 
1 19  GLU n 
1 20  MET n 
1 21  SER n 
1 22  ARG n 
1 23  SER n 
1 24  GLY n 
1 25  ASN n 
1 26  GLN n 
1 27  VAL n 
1 28  SER n 
1 29  GLU n 
1 30  PHE n 
1 31  ILE n 
1 32  SER n 
1 33  ASN n 
1 34  THR n 
1 35  PHE n 
1 36  LEU n 
1 37  ASP n 
1 38  LYS n 
1 39  GLN n 
1 40  HIS n 
1 41  GLU n 
1 42  VAL n 
1 43  GLU n 
1 44  ILE n 
1 45  PRO n 
1 46  SER n 
1 47  PRO n 
1 48  THR n 
1 49  GLN n 
1 50  LYS n 
1 51  GLU n 
1 52  LYS n 
1 53  GLU n 
1 54  LYS n 
1 55  LYS n 
1 56  LYS n 
1 57  ARG n 
1 58  PRO n 
1 59  MET n 
1 60  SER n 
1 61  GLN n 
1 62  ILE n 
1 63  SER n 
1 64  GLY n 
1 65  VAL n 
1 66  LYS n 
1 67  LYS n 
1 68  LEU n 
1 69  MET n 
1 70  HIS n 
1 71  SER n 
1 72  SER n 
1 73  SER n 
1 74  LEU n 
1 75  THR n 
1 76  ASN n 
1 77  SER n 
1 78  SER n 
1 79  ILE n 
1 80  PRO n 
1 81  ARG n 
1 82  PHE n 
1 83  GLY n 
1 84  VAL n 
1 85  LYS n 
1 86  THR n 
1 87  GLU n 
1 88  GLN n 
1 89  GLU n 
1 90  ASP n 
1 91  VAL n 
1 92  LEU n 
1 93  ALA n 
1 94  LYS n 
1 95  GLU n 
1 96  LEU n 
1 97  GLU n 
1 98  ASP n 
1 99  VAL n 
1 100 ASN n 
1 101 LYS n 
1 102 TRP n 
1 103 GLY n 
1 104 LEU n 
1 105 HIS n 
1 106 VAL n 
1 107 PHE n 
1 108 ARG n 
1 109 ILE n 
1 110 ALA n 
1 111 GLU n 
1 112 LEU n 
1 113 SER n 
1 114 GLY n 
1 115 ASN n 
1 116 ARG n 
1 117 PRO n 
1 118 LEU n 
1 119 THR n 
1 120 VAL n 
1 121 ILE n 
1 122 MET n 
1 123 HIS n 
1 124 THR n 
1 125 ILE n 
1 126 PHE n 
1 127 GLN n 
1 128 GLU n 
1 129 ARG n 
1 130 ASP n 
1 131 LEU n 
1 132 LEU n 
1 133 LYS n 
1 134 THR n 
1 135 PHE n 
1 136 LYS n 
1 137 ILE n 
1 138 PRO n 
1 139 VAL n 
1 140 ASP n 
1 141 THR n 
1 142 LEU n 
1 143 ILE n 
1 144 THR n 
1 145 TYR n 
1 146 LEU n 
1 147 MET n 
1 148 THR n 
1 149 LEU n 
1 150 GLU n 
1 151 ASP n 
1 152 HIS n 
1 153 TYR n 
1 154 HIS n 
1 155 ALA n 
1 156 ASP n 
1 157 VAL n 
1 158 ALA n 
1 159 TYR n 
1 160 HIS n 
1 161 ASN n 
1 162 ASN n 
1 163 ILE n 
1 164 HIS n 
1 165 ALA n 
1 166 ALA n 
1 167 ASP n 
1 168 VAL n 
1 169 VAL n 
1 170 GLN n 
1 171 SER n 
1 172 THR n 
1 173 HIS n 
1 174 VAL n 
1 175 LEU n 
1 176 LEU n 
1 177 SER n 
1 178 THR n 
1 179 PRO n 
1 180 ALA n 
1 181 LEU n 
1 182 GLU n 
1 183 ALA n 
1 184 VAL n 
1 185 PHE n 
1 186 THR n 
1 187 ASP n 
1 188 LEU n 
1 189 GLU n 
1 190 ILE n 
1 191 LEU n 
1 192 ALA n 
1 193 ALA n 
1 194 ILE n 
1 195 PHE n 
1 196 ALA n 
1 197 SER n 
1 198 ALA n 
1 199 ILE n 
1 200 HIS n 
1 201 ASP n 
1 202 VAL n 
1 203 ASP n 
1 204 HIS n 
1 205 PRO n 
1 206 GLY n 
1 207 VAL n 
1 208 SER n 
1 209 ASN n 
1 210 GLN n 
1 211 PHE n 
1 212 LEU n 
1 213 ILE n 
1 214 ASN n 
1 215 THR n 
1 216 ASN n 
1 217 SER n 
1 218 GLU n 
1 219 LEU n 
1 220 ALA n 
1 221 LEU n 
1 222 MET n 
1 223 TYR n 
1 224 ASN n 
1 225 ASP n 
1 226 SER n 
1 227 SER n 
1 228 VAL n 
1 229 LEU n 
1 230 GLU n 
1 231 ASN n 
1 232 HIS n 
1 233 HIS n 
1 234 LEU n 
1 235 ALA n 
1 236 VAL n 
1 237 GLY n 
1 238 PHE n 
1 239 LYS n 
1 240 LEU n 
1 241 LEU n 
1 242 GLN n 
1 243 GLU n 
1 244 GLU n 
1 245 ASN n 
1 246 CYS n 
1 247 ASP n 
1 248 ILE n 
1 249 PHE n 
1 250 GLN n 
1 251 ASN n 
1 252 LEU n 
1 253 THR n 
1 254 LYS n 
1 255 LYS n 
1 256 GLN n 
1 257 ARG n 
1 258 GLN n 
1 259 SER n 
1 260 LEU n 
1 261 ARG n 
1 262 LYS n 
1 263 MET n 
1 264 VAL n 
1 265 ILE n 
1 266 ASP n 
1 267 ILE n 
1 268 VAL n 
1 269 LEU n 
1 270 ALA n 
1 271 THR n 
1 272 ASP n 
1 273 MET n 
1 274 SER n 
1 275 LYS n 
1 276 HIS n 
1 277 MET n 
1 278 ASN n 
1 279 LEU n 
1 280 LEU n 
1 281 ALA n 
1 282 ASP n 
1 283 LEU n 
1 284 LYS n 
1 285 THR n 
1 286 MET n 
1 287 VAL n 
1 288 GLU n 
1 289 THR n 
1 290 LYS n 
1 291 LYS n 
1 292 VAL n 
1 293 THR n 
1 294 SER n 
1 295 SER n 
1 296 GLY n 
1 297 VAL n 
1 298 LEU n 
1 299 LEU n 
1 300 LEU n 
1 301 ASP n 
1 302 ASN n 
1 303 TYR n 
1 304 SER n 
1 305 ASP n 
1 306 ARG n 
1 307 ILE n 
1 308 GLN n 
1 309 VAL n 
1 310 LEU n 
1 311 GLN n 
1 312 ASN n 
1 313 MET n 
1 314 VAL n 
1 315 HIS n 
1 316 CYS n 
1 317 ALA n 
1 318 ASP n 
1 319 LEU n 
1 320 SER n 
1 321 ASN n 
1 322 PRO n 
1 323 THR n 
1 324 LYS n 
1 325 PRO n 
1 326 LEU n 
1 327 GLN n 
1 328 LEU n 
1 329 TYR n 
1 330 ARG n 
1 331 GLN n 
1 332 TRP n 
1 333 THR n 
1 334 ASP n 
1 335 ARG n 
1 336 ILE n 
1 337 MET n 
1 338 GLU n 
1 339 GLU n 
1 340 PHE n 
1 341 PHE n 
1 342 ARG n 
1 343 GLN n 
1 344 GLY n 
1 345 ASP n 
1 346 ARG n 
1 347 GLU n 
1 348 ARG n 
1 349 GLU n 
1 350 ARG n 
1 351 GLY n 
1 352 MET n 
1 353 GLU n 
1 354 ILE n 
1 355 SER n 
1 356 PRO n 
1 357 MET n 
1 358 CYS n 
1 359 ASP n 
1 360 LYS n 
1 361 HIS n 
1 362 ASN n 
1 363 ALA n 
1 364 SER n 
1 365 VAL n 
1 366 GLU n 
1 367 LYS n 
1 368 SER n 
1 369 GLN n 
1 370 VAL n 
1 371 GLY n 
1 372 PHE n 
1 373 ILE n 
1 374 ASP n 
1 375 TYR n 
1 376 ILE n 
1 377 VAL n 
1 378 HIS n 
1 379 PRO n 
1 380 LEU n 
1 381 TRP n 
1 382 GLU n 
1 383 THR n 
1 384 TRP n 
1 385 ALA n 
1 386 ASP n 
1 387 LEU n 
1 388 VAL n 
1 389 HIS n 
1 390 PRO n 
1 391 ASP n 
1 392 ALA n 
1 393 GLN n 
1 394 ASP n 
1 395 ILE n 
1 396 LEU n 
1 397 ASP n 
1 398 THR n 
1 399 LEU n 
1 400 GLU n 
1 401 ASP n 
1 402 ASN n 
1 403 ARG n 
1 404 GLU n 
1 405 TRP n 
1 406 TYR n 
1 407 GLN n 
1 408 SER n 
1 409 THR n 
1 410 ILE n 
1 411 PRO n 
1 412 GLN n 
1 413 SER n 
1 414 PRO n 
1 415 SER n 
1 416 PRO n 
1 417 ALA n 
1 418 PRO n 
1 419 ASP n 
1 420 ASP n 
1 421 PRO n 
1 422 GLU n 
1 423 GLU n 
1 424 GLY n 
1 425 ARG n 
1 426 GLN n 
1 427 GLY n 
1 428 GLN n 
1 429 THR n 
1 430 GLU n 
1 431 LYS n 
1 432 PHE n 
1 433 GLN n 
1 434 PHE n 
1 435 GLU n 
1 436 LEU n 
1 437 THR n 
1 438 LEU n 
1 439 GLU n 
1 440 GLU n 
1 441 ASP n 
1 442 GLY n 
1 443 GLU n 
1 444 SER n 
1 445 ASP n 
1 446 THR n 
1 447 GLU n 
1 448 LYS n 
1 449 ASP n 
1 450 SER n 
1 451 GLY n 
1 452 SER n 
1 453 GLN n 
1 454 VAL n 
1 455 GLU n 
1 456 GLU n 
1 457 ASP n 
1 458 THR n 
1 459 SER n 
1 460 CYS n 
1 461 SER n 
1 462 ASP n 
1 463 SER n 
1 464 LYS n 
1 465 THR n 
1 466 LEU n 
1 467 CYS n 
1 468 THR n 
1 469 GLN n 
1 470 ASP n 
1 471 SER n 
1 472 GLU n 
1 473 SER n 
1 474 THR n 
1 475 GLU n 
1 476 ILE n 
1 477 PRO n 
1 478 LEU n 
1 479 ASP n 
1 480 GLU n 
1 481 GLN n 
1 482 VAL n 
1 483 GLU n 
1 484 GLU n 
1 485 GLU n 
1 486 ALA n 
1 487 VAL n 
1 488 GLY n 
1 489 GLU n 
1 490 GLU n 
1 491 GLU n 
1 492 GLU n 
1 493 SER n 
1 494 GLN n 
1 495 PRO n 
1 496 GLU n 
1 497 ALA n 
1 498 CYS n 
1 499 VAL n 
1 500 ILE n 
1 501 ASP n 
1 502 ASP n 
1 503 ARG n 
1 504 SER n 
1 505 PRO n 
1 506 ASP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   506 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'PDE4D, DPDE3' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     511693 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1EKX non-polymer         . 
;methyl 4-[[2-[4-[bis(fluoranyl)methoxy]-3-(cyclopropen-1-ylmethoxy)phenyl]-6-oxidanyl-1-benzofuran-7-yl]oxy]-1~{H}-pyrrole-2-carboxylate
;
? 'C25 H19 F2 N O7' 483.418 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'      89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'  175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'     132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'      133.103 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'    121.158 
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'    146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'      147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'      75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'  156.162 
HOH   non-polymer         . WATER ? 'H2 O'            18.015  
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'     131.173 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'     131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'  147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'   149.211 
MG    non-polymer         . 'MAGNESIUM ION' ? 'Mg 2'            24.305  
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'     165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'      115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'      105.093 
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'      119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'   204.225 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'     181.189 
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'     117.146 
ZN    non-polymer         . 'ZINC ION' ? 'Zn 2'            65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ALA 2   2   ?   ?   ?   A . n 
A 1 3   SER 3   3   ?   ?   ?   A . n 
A 1 4   ASN 4   4   ?   ?   ?   A . n 
A 1 5   LYS 5   5   ?   ?   ?   A . n 
A 1 6   PHE 6   6   ?   ?   ?   A . n 
A 1 7   LYS 7   7   ?   ?   ?   A . n 
A 1 8   ARG 8   8   ?   ?   ?   A . n 
A 1 9   MET 9   9   ?   ?   ?   A . n 
A 1 10  LEU 10  10  ?   ?   ?   A . n 
A 1 11  ASN 11  11  ?   ?   ?   A . n 
A 1 12  ARG 12  12  ?   ?   ?   A . n 
A 1 13  GLU 13  13  ?   ?   ?   A . n 
A 1 14  LEU 14  14  ?   ?   ?   A . n 
A 1 15  THR 15  15  ?   ?   ?   A . n 
A 1 16  HIS 16  16  ?   ?   ?   A . n 
A 1 17  LEU 17  17  ?   ?   ?   A . n 
A 1 18  SER 18  18  ?   ?   ?   A . n 
A 1 19  GLU 19  19  ?   ?   ?   A . n 
A 1 20  MET 20  20  ?   ?   ?   A . n 
A 1 21  SER 21  21  ?   ?   ?   A . n 
A 1 22  ARG 22  22  ?   ?   ?   A . n 
A 1 23  SER 23  23  ?   ?   ?   A . n 
A 1 24  GLY 24  24  ?   ?   ?   A . n 
A 1 25  ASN 25  25  ?   ?   ?   A . n 
A 1 26  GLN 26  26  ?   ?   ?   A . n 
A 1 27  VAL 27  27  ?   ?   ?   A . n 
A 1 28  SER 28  28  ?   ?   ?   A . n 
A 1 29  GLU 29  29  ?   ?   ?   A . n 
A 1 30  PHE 30  30  ?   ?   ?   A . n 
A 1 31  ILE 31  31  ?   ?   ?   A . n 
A 1 32  SER 32  32  ?   ?   ?   A . n 
A 1 33  ASN 33  33  ?   ?   ?   A . n 
A 1 34  THR 34  34  ?   ?   ?   A . n 
A 1 35  PHE 35  35  ?   ?   ?   A . n 
A 1 36  LEU 36  36  ?   ?   ?   A . n 
A 1 37  ASP 37  37  ?   ?   ?   A . n 
A 1 38  LYS 38  38  ?   ?   ?   A . n 
A 1 39  GLN 39  39  ?   ?   ?   A . n 
A 1 40  HIS 40  40  ?   ?   ?   A . n 
A 1 41  GLU 41  41  ?   ?   ?   A . n 
A 1 42  VAL 42  42  ?   ?   ?   A . n 
A 1 43  GLU 43  43  ?   ?   ?   A . n 
A 1 44  ILE 44  44  ?   ?   ?   A . n 
A 1 45  PRO 45  45  ?   ?   ?   A . n 
A 1 46  SER 46  46  ?   ?   ?   A . n 
A 1 47  PRO 47  47  ?   ?   ?   A . n 
A 1 48  THR 48  48  ?   ?   ?   A . n 
A 1 49  GLN 49  49  ?   ?   ?   A . n 
A 1 50  LYS 50  50  ?   ?   ?   A . n 
A 1 51  GLU 51  51  ?   ?   ?   A . n 
A 1 52  LYS 52  52  ?   ?   ?   A . n 
A 1 53  GLU 53  53  ?   ?   ?   A . n 
A 1 54  LYS 54  54  ?   ?   ?   A . n 
A 1 55  LYS 55  55  ?   ?   ?   A . n 
A 1 56  LYS 56  56  ?   ?   ?   A . n 
A 1 57  ARG 57  57  ?   ?   ?   A . n 
A 1 58  PRO 58  58  ?   ?   ?   A . n 
A 1 59  MET 59  59  ?   ?   ?   A . n 
A 1 60  SER 60  60  ?   ?   ?   A . n 
A 1 61  GLN 61  61  ?   ?   ?   A . n 
A 1 62  ILE 62  62  ?   ?   ?   A . n 
A 1 63  SER 63  63  ?   ?   ?   A . n 
A 1 64  GLY 64  64  ?   ?   ?   A . n 
A 1 65  VAL 65  65  ?   ?   ?   A . n 
A 1 66  LYS 66  66  ?   ?   ?   A . n 
A 1 67  LYS 67  67  ?   ?   ?   A . n 
A 1 68  LEU 68  68  ?   ?   ?   A . n 
A 1 69  MET 69  69  ?   ?   ?   A . n 
A 1 70  HIS 70  70  ?   ?   ?   A . n 
A 1 71  SER 71  71  ?   ?   ?   A . n 
A 1 72  SER 72  72  ?   ?   ?   A . n 
A 1 73  SER 73  73  ?   ?   ?   A . n 
A 1 74  LEU 74  74  ?   ?   ?   A . n 
A 1 75  THR 75  75  ?   ?   ?   A . n 
A 1 76  ASN 76  76  ?   ?   ?   A . n 
A 1 77  SER 77  77  ?   ?   ?   A . n 
A 1 78  SER 78  78  ?   ?   ?   A . n 
A 1 79  ILE 79  79  ?   ?   ?   A . n 
A 1 80  PRO 80  80  ?   ?   ?   A . n 
A 1 81  ARG 81  81  ?   ?   ?   A . n 
A 1 82  PHE 82  82  ?   ?   ?   A . n 
A 1 83  GLY 83  83  ?   ?   ?   A . n 
A 1 84  VAL 84  84  ?   ?   ?   A . n 
A 1 85  LYS 85  85  ?   ?   ?   A . n 
A 1 86  THR 86  86  ?   ?   ?   A . n 
A 1 87  GLU 87  87  ?   ?   ?   A . n 
A 1 88  GLN 88  88  88  GLN GLN A . n 
A 1 89  GLU 89  89  89  GLU GLU A . n 
A 1 90  ASP 90  90  90  ASP ASP A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  LEU 92  92  92  LEU LEU A . n 
A 1 93  ALA 93  93  93  ALA ALA A . n 
A 1 94  LYS 94  94  94  LYS LYS A . n 
A 1 95  GLU 95  95  95  GLU GLU A . n 
A 1 96  LEU 96  96  96  LEU LEU A . n 
A 1 97  GLU 97  97  97  GLU GLU A . n 
A 1 98  ASP 98  98  98  ASP ASP A . n 
A 1 99  VAL 99  99  99  VAL VAL A . n 
A 1 100 ASN 100 100 100 ASN ASN A . n 
A 1 101 LYS 101 101 101 LYS LYS A . n 
A 1 102 TRP 102 102 102 TRP TRP A . n 
A 1 103 GLY 103 103 103 GLY GLY A . n 
A 1 104 LEU 104 104 104 LEU LEU A . n 
A 1 105 HIS 105 105 105 HIS HIS A . n 
A 1 106 VAL 106 106 106 VAL VAL A . n 
A 1 107 PHE 107 107 107 PHE PHE A . n 
A 1 108 ARG 108 108 108 ARG ARG A . n 
A 1 109 ILE 109 109 109 ILE ILE A . n 
A 1 110 ALA 110 110 110 ALA ALA A . n 
A 1 111 GLU 111 111 111 GLU GLU A . n 
A 1 112 LEU 112 112 112 LEU LEU A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 GLY 114 114 114 GLY GLY A . n 
A 1 115 ASN 115 115 115 ASN ASN A . n 
A 1 116 ARG 116 116 116 ARG ARG A . n 
A 1 117 PRO 117 117 117 PRO PRO A . n 
A 1 118 LEU 118 118 118 LEU LEU A . n 
A 1 119 THR 119 119 119 THR THR A . n 
A 1 120 VAL 120 120 120 VAL VAL A . n 
A 1 121 ILE 121 121 121 ILE ILE A . n 
A 1 122 MET 122 122 122 MET MET A . n 
A 1 123 HIS 123 123 123 HIS HIS A . n 
A 1 124 THR 124 124 124 THR THR A . n 
A 1 125 ILE 125 125 125 ILE ILE A . n 
A 1 126 PHE 126 126 126 PHE PHE A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 GLU 128 128 128 GLU GLU A . n 
A 1 129 ARG 129 129 129 ARG ARG A . n 
A 1 130 ASP 130 130 130 ASP ASP A . n 
A 1 131 LEU 131 131 131 LEU LEU A . n 
A 1 132 LEU 132 132 132 LEU LEU A . n 
A 1 133 LYS 133 133 133 LYS LYS A . n 
A 1 134 THR 134 134 134 THR THR A . n 
A 1 135 PHE 135 135 135 PHE PHE A . n 
A 1 136 LYS 136 136 136 LYS LYS A . n 
A 1 137 ILE 137 137 137 ILE ILE A . n 
A 1 138 PRO 138 138 138 PRO PRO A . n 
A 1 139 VAL 139 139 139 VAL VAL A . n 
A 1 140 ASP 140 140 140 ASP ASP A . n 
A 1 141 THR 141 141 141 THR THR A . n 
A 1 142 LEU 142 142 142 LEU LEU A . n 
A 1 143 ILE 143 143 143 ILE ILE A . n 
A 1 144 THR 144 144 144 THR THR A . n 
A 1 145 TYR 145 145 145 TYR TYR A . n 
A 1 146 LEU 146 146 146 LEU LEU A . n 
A 1 147 MET 147 147 147 MET MET A . n 
A 1 148 THR 148 148 148 THR THR A . n 
A 1 149 LEU 149 149 149 LEU LEU A . n 
A 1 150 GLU 150 150 150 GLU GLU A . n 
A 1 151 ASP 151 151 151 ASP ASP A . n 
A 1 152 HIS 152 152 152 HIS HIS A . n 
A 1 153 TYR 153 153 153 TYR TYR A . n 
A 1 154 HIS 154 154 154 HIS HIS A . n 
A 1 155 ALA 155 155 155 ALA ALA A . n 
A 1 156 ASP 156 156 156 ASP ASP A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 ALA 158 158 158 ALA ALA A . n 
A 1 159 TYR 159 159 159 TYR TYR A . n 
A 1 160 HIS 160 160 160 HIS HIS A . n 
A 1 161 ASN 161 161 161 ASN ASN A . n 
A 1 162 ASN 162 162 162 ASN ASN A . n 
A 1 163 ILE 163 163 163 ILE ILE A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 ALA 165 165 165 ALA ALA A . n 
A 1 166 ALA 166 166 166 ALA ALA A . n 
A 1 167 ASP 167 167 167 ASP ASP A . n 
A 1 168 VAL 168 168 168 VAL VAL A . n 
A 1 169 VAL 169 169 169 VAL VAL A . n 
A 1 170 GLN 170 170 170 GLN GLN A . n 
A 1 171 SER 171 171 171 SER SER A . n 
A 1 172 THR 172 172 172 THR THR A . n 
A 1 173 HIS 173 173 173 HIS HIS A . n 
A 1 174 VAL 174 174 174 VAL VAL A . n 
A 1 175 LEU 175 175 175 LEU LEU A . n 
A 1 176 LEU 176 176 176 LEU LEU A . n 
A 1 177 SER 177 177 177 SER SER A . n 
A 1 178 THR 178 178 178 THR THR A . n 
A 1 179 PRO 179 179 179 PRO PRO A . n 
A 1 180 ALA 180 180 180 ALA ALA A . n 
A 1 181 LEU 181 181 181 LEU LEU A . n 
A 1 182 GLU 182 182 182 GLU GLU A . n 
A 1 183 ALA 183 183 183 ALA ALA A . n 
A 1 184 VAL 184 184 184 VAL VAL A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 THR 186 186 186 THR THR A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 LEU 188 188 188 LEU LEU A . n 
A 1 189 GLU 189 189 189 GLU GLU A . n 
A 1 190 ILE 190 190 190 ILE ILE A . n 
A 1 191 LEU 191 191 191 LEU LEU A . n 
A 1 192 ALA 192 192 192 ALA ALA A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ILE 194 194 194 ILE ILE A . n 
A 1 195 PHE 195 195 195 PHE PHE A . n 
A 1 196 ALA 196 196 196 ALA ALA A . n 
A 1 197 SER 197 197 197 SER SER A . n 
A 1 198 ALA 198 198 198 ALA ALA A . n 
A 1 199 ILE 199 199 199 ILE ILE A . n 
A 1 200 HIS 200 200 200 HIS HIS A . n 
A 1 201 ASP 201 201 201 ASP ASP A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASP 203 203 203 ASP ASP A . n 
A 1 204 HIS 204 204 204 HIS HIS A . n 
A 1 205 PRO 205 205 205 PRO PRO A . n 
A 1 206 GLY 206 206 206 GLY GLY A . n 
A 1 207 VAL 207 207 207 VAL VAL A . n 
A 1 208 SER 208 208 208 SER SER A . n 
A 1 209 ASN 209 209 209 ASN ASN A . n 
A 1 210 GLN 210 210 210 GLN GLN A . n 
A 1 211 PHE 211 211 211 PHE PHE A . n 
A 1 212 LEU 212 212 212 LEU LEU A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 THR 215 215 215 THR THR A . n 
A 1 216 ASN 216 216 216 ASN ASN A . n 
A 1 217 SER 217 217 217 SER SER A . n 
A 1 218 GLU 218 218 218 GLU GLU A . n 
A 1 219 LEU 219 219 219 LEU LEU A . n 
A 1 220 ALA 220 220 220 ALA ALA A . n 
A 1 221 LEU 221 221 221 LEU LEU A . n 
A 1 222 MET 222 222 222 MET MET A . n 
A 1 223 TYR 223 223 223 TYR TYR A . n 
A 1 224 ASN 224 224 224 ASN ASN A . n 
A 1 225 ASP 225 225 225 ASP ASP A . n 
A 1 226 SER 226 226 226 SER SER A . n 
A 1 227 SER 227 227 227 SER SER A . n 
A 1 228 VAL 228 228 228 VAL VAL A . n 
A 1 229 LEU 229 229 229 LEU LEU A . n 
A 1 230 GLU 230 230 230 GLU GLU A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 HIS 232 232 232 HIS HIS A . n 
A 1 233 HIS 233 233 233 HIS HIS A . n 
A 1 234 LEU 234 234 234 LEU LEU A . n 
A 1 235 ALA 235 235 235 ALA ALA A . n 
A 1 236 VAL 236 236 236 VAL VAL A . n 
A 1 237 GLY 237 237 237 GLY GLY A . n 
A 1 238 PHE 238 238 238 PHE PHE A . n 
A 1 239 LYS 239 239 239 LYS LYS A . n 
A 1 240 LEU 240 240 240 LEU LEU A . n 
A 1 241 LEU 241 241 241 LEU LEU A . n 
A 1 242 GLN 242 242 242 GLN GLN A . n 
A 1 243 GLU 243 243 243 GLU GLU A . n 
A 1 244 GLU 244 244 244 GLU GLU A . n 
A 1 245 ASN 245 245 245 ASN ASN A . n 
A 1 246 CYS 246 246 246 CYS CYS A . n 
A 1 247 ASP 247 247 247 ASP ASP A . n 
A 1 248 ILE 248 248 248 ILE ILE A . n 
A 1 249 PHE 249 249 249 PHE PHE A . n 
A 1 250 GLN 250 250 250 GLN GLN A . n 
A 1 251 ASN 251 251 251 ASN ASN A . n 
A 1 252 LEU 252 252 252 LEU LEU A . n 
A 1 253 THR 253 253 253 THR THR A . n 
A 1 254 LYS 254 254 254 LYS LYS A . n 
A 1 255 LYS 255 255 255 LYS LYS A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 ARG 257 257 257 ARG ARG A . n 
A 1 258 GLN 258 258 258 GLN GLN A . n 
A 1 259 SER 259 259 259 SER SER A . n 
A 1 260 LEU 260 260 260 LEU LEU A . n 
A 1 261 ARG 261 261 261 ARG ARG A . n 
A 1 262 LYS 262 262 262 LYS LYS A . n 
A 1 263 MET 263 263 263 MET MET A . n 
A 1 264 VAL 264 264 264 VAL VAL A . n 
A 1 265 ILE 265 265 265 ILE ILE A . n 
A 1 266 ASP 266 266 266 ASP ASP A . n 
A 1 267 ILE 267 267 267 ILE ILE A . n 
A 1 268 VAL 268 268 268 VAL VAL A . n 
A 1 269 LEU 269 269 269 LEU LEU A . n 
A 1 270 ALA 270 270 270 ALA ALA A . n 
A 1 271 THR 271 271 271 THR THR A . n 
A 1 272 ASP 272 272 272 ASP ASP A . n 
A 1 273 MET 273 273 273 MET MET A . n 
A 1 274 SER 274 274 274 SER SER A . n 
A 1 275 LYS 275 275 275 LYS LYS A . n 
A 1 276 HIS 276 276 276 HIS HIS A . n 
A 1 277 MET 277 277 277 MET MET A . n 
A 1 278 ASN 278 278 278 ASN ASN A . n 
A 1 279 LEU 279 279 279 LEU LEU A . n 
A 1 280 LEU 280 280 280 LEU LEU A . n 
A 1 281 ALA 281 281 281 ALA ALA A . n 
A 1 282 ASP 282 282 282 ASP ASP A . n 
A 1 283 LEU 283 283 283 LEU LEU A . n 
A 1 284 LYS 284 284 284 LYS LYS A . n 
A 1 285 THR 285 285 285 THR THR A . n 
A 1 286 MET 286 286 286 MET MET A . n 
A 1 287 VAL 287 287 287 VAL VAL A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 THR 289 289 289 THR THR A . n 
A 1 290 LYS 290 290 290 LYS LYS A . n 
A 1 291 LYS 291 291 291 LYS LYS A . n 
A 1 292 VAL 292 292 292 VAL VAL A . n 
A 1 293 THR 293 293 293 THR THR A . n 
A 1 294 SER 294 294 294 SER SER A . n 
A 1 295 SER 295 295 295 SER SER A . n 
A 1 296 GLY 296 296 296 GLY GLY A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 LEU 298 298 298 LEU LEU A . n 
A 1 299 LEU 299 299 299 LEU LEU A . n 
A 1 300 LEU 300 300 300 LEU LEU A . n 
A 1 301 ASP 301 301 301 ASP ASP A . n 
A 1 302 ASN 302 302 302 ASN ASN A . n 
A 1 303 TYR 303 303 303 TYR TYR A . n 
A 1 304 SER 304 304 304 SER SER A . n 
A 1 305 ASP 305 305 305 ASP ASP A . n 
A 1 306 ARG 306 306 306 ARG ARG A . n 
A 1 307 ILE 307 307 307 ILE ILE A . n 
A 1 308 GLN 308 308 308 GLN GLN A . n 
A 1 309 VAL 309 309 309 VAL VAL A . n 
A 1 310 LEU 310 310 310 LEU LEU A . n 
A 1 311 GLN 311 311 311 GLN GLN A . n 
A 1 312 ASN 312 312 312 ASN ASN A . n 
A 1 313 MET 313 313 313 MET MET A . n 
A 1 314 VAL 314 314 314 VAL VAL A . n 
A 1 315 HIS 315 315 315 HIS HIS A . n 
A 1 316 CYS 316 316 316 CYS CYS A . n 
A 1 317 ALA 317 317 317 ALA ALA A . n 
A 1 318 ASP 318 318 318 ASP ASP A . n 
A 1 319 LEU 319 319 319 LEU LEU A . n 
A 1 320 SER 320 320 320 SER SER A . n 
A 1 321 ASN 321 321 321 ASN ASN A . n 
A 1 322 PRO 322 322 322 PRO PRO A . n 
A 1 323 THR 323 323 323 THR THR A . n 
A 1 324 LYS 324 324 324 LYS LYS A . n 
A 1 325 PRO 325 325 325 PRO PRO A . n 
A 1 326 LEU 326 326 326 LEU LEU A . n 
A 1 327 GLN 327 327 327 GLN GLN A . n 
A 1 328 LEU 328 328 328 LEU LEU A . n 
A 1 329 TYR 329 329 329 TYR TYR A . n 
A 1 330 ARG 330 330 330 ARG ARG A . n 
A 1 331 GLN 331 331 331 GLN GLN A . n 
A 1 332 TRP 332 332 332 TRP TRP A . n 
A 1 333 THR 333 333 333 THR THR A . n 
A 1 334 ASP 334 334 334 ASP ASP A . n 
A 1 335 ARG 335 335 335 ARG ARG A . n 
A 1 336 ILE 336 336 336 ILE ILE A . n 
A 1 337 MET 337 337 337 MET MET A . n 
A 1 338 GLU 338 338 338 GLU GLU A . n 
A 1 339 GLU 339 339 339 GLU GLU A . n 
A 1 340 PHE 340 340 340 PHE PHE A . n 
A 1 341 PHE 341 341 341 PHE PHE A . n 
A 1 342 ARG 342 342 342 ARG ARG A . n 
A 1 343 GLN 343 343 343 GLN GLN A . n 
A 1 344 GLY 344 344 344 GLY GLY A . n 
A 1 345 ASP 345 345 345 ASP ASP A . n 
A 1 346 ARG 346 346 346 ARG ARG A . n 
A 1 347 GLU 347 347 347 GLU GLU A . n 
A 1 348 ARG 348 348 348 ARG ARG A . n 
A 1 349 GLU 349 349 349 GLU GLU A . n 
A 1 350 ARG 350 350 350 ARG ARG A . n 
A 1 351 GLY 351 351 351 GLY GLY A . n 
A 1 352 MET 352 352 352 MET MET A . n 
A 1 353 GLU 353 353 353 GLU GLU A . n 
A 1 354 ILE 354 354 354 ILE ILE A . n 
A 1 355 SER 355 355 355 SER SER A . n 
A 1 356 PRO 356 356 356 PRO PRO A . n 
A 1 357 MET 357 357 357 MET MET A . n 
A 1 358 CYS 358 358 358 CYS CYS A . n 
A 1 359 ASP 359 359 359 ASP ASP A . n 
A 1 360 LYS 360 360 360 LYS LYS A . n 
A 1 361 HIS 361 361 361 HIS HIS A . n 
A 1 362 ASN 362 362 362 ASN ASN A . n 
A 1 363 ALA 363 363 363 ALA ALA A . n 
A 1 364 SER 364 364 364 SER SER A . n 
A 1 365 VAL 365 365 365 VAL VAL A . n 
A 1 366 GLU 366 366 366 GLU GLU A . n 
A 1 367 LYS 367 367 367 LYS LYS A . n 
A 1 368 SER 368 368 368 SER SER A . n 
A 1 369 GLN 369 369 369 GLN GLN A . n 
A 1 370 VAL 370 370 370 VAL VAL A . n 
A 1 371 GLY 371 371 371 GLY GLY A . n 
A 1 372 PHE 372 372 372 PHE PHE A . n 
A 1 373 ILE 373 373 373 ILE ILE A . n 
A 1 374 ASP 374 374 374 ASP ASP A . n 
A 1 375 TYR 375 375 375 TYR TYR A . n 
A 1 376 ILE 376 376 376 ILE ILE A . n 
A 1 377 VAL 377 377 377 VAL VAL A . n 
A 1 378 HIS 378 378 378 HIS HIS A . n 
A 1 379 PRO 379 379 379 PRO PRO A . n 
A 1 380 LEU 380 380 380 LEU LEU A . n 
A 1 381 TRP 381 381 381 TRP TRP A . n 
A 1 382 GLU 382 382 382 GLU GLU A . n 
A 1 383 THR 383 383 383 THR THR A . n 
A 1 384 TRP 384 384 384 TRP TRP A . n 
A 1 385 ALA 385 385 385 ALA ALA A . n 
A 1 386 ASP 386 386 386 ASP ASP A . n 
A 1 387 LEU 387 387 387 LEU LEU A . n 
A 1 388 VAL 388 388 388 VAL VAL A . n 
A 1 389 HIS 389 389 389 HIS HIS A . n 
A 1 390 PRO 390 390 390 PRO PRO A . n 
A 1 391 ASP 391 391 391 ASP ASP A . n 
A 1 392 ALA 392 392 392 ALA ALA A . n 
A 1 393 GLN 393 393 393 GLN GLN A . n 
A 1 394 ASP 394 394 394 ASP ASP A . n 
A 1 395 ILE 395 395 395 ILE ILE A . n 
A 1 396 LEU 396 396 396 LEU LEU A . n 
A 1 397 ASP 397 397 397 ASP ASP A . n 
A 1 398 THR 398 398 398 THR THR A . n 
A 1 399 LEU 399 399 399 LEU LEU A . n 
A 1 400 GLU 400 400 400 GLU GLU A . n 
A 1 401 ASP 401 401 401 ASP ASP A . n 
A 1 402 ASN 402 402 402 ASN ASN A . n 
A 1 403 ARG 403 403 403 ARG ARG A . n 
A 1 404 GLU 404 404 404 GLU GLU A . n 
A 1 405 TRP 405 405 405 TRP TRP A . n 
A 1 406 TYR 406 406 406 TYR TYR A . n 
A 1 407 GLN 407 407 407 GLN GLN A . n 
A 1 408 SER 408 408 408 SER SER A . n 
A 1 409 THR 409 409 409 THR THR A . n 
A 1 410 ILE 410 410 410 ILE ILE A . n 
A 1 411 PRO 411 411 411 PRO PRO A . n 
A 1 412 GLN 412 412 ?   ?   ?   A . n 
A 1 413 SER 413 413 ?   ?   ?   A . n 
A 1 414 PRO 414 414 ?   ?   ?   A . n 
A 1 415 SER 415 415 ?   ?   ?   A . n 
A 1 416 PRO 416 416 ?   ?   ?   A . n 
A 1 417 ALA 417 417 ?   ?   ?   A . n 
A 1 418 PRO 418 418 ?   ?   ?   A . n 
A 1 419 ASP 419 419 ?   ?   ?   A . n 
A 1 420 ASP 420 420 ?   ?   ?   A . n 
A 1 421 PRO 421 421 ?   ?   ?   A . n 
A 1 422 GLU 422 422 ?   ?   ?   A . n 
A 1 423 GLU 423 423 ?   ?   ?   A . n 
A 1 424 GLY 424 424 ?   ?   ?   A . n 
A 1 425 ARG 425 425 ?   ?   ?   A . n 
A 1 426 GLN 426 426 ?   ?   ?   A . n 
A 1 427 GLY 427 427 ?   ?   ?   A . n 
A 1 428 GLN 428 428 ?   ?   ?   A . n 
A 1 429 THR 429 429 ?   ?   ?   A . n 
A 1 430 GLU 430 430 ?   ?   ?   A . n 
A 1 431 LYS 431 431 ?   ?   ?   A . n 
A 1 432 PHE 432 432 ?   ?   ?   A . n 
A 1 433 GLN 433 433 ?   ?   ?   A . n 
A 1 434 PHE 434 434 ?   ?   ?   A . n 
A 1 435 GLU 435 435 ?   ?   ?   A . n 
A 1 436 LEU 436 436 ?   ?   ?   A . n 
A 1 437 THR 437 437 ?   ?   ?   A . n 
A 1 438 LEU 438 438 ?   ?   ?   A . n 
A 1 439 GLU 439 439 ?   ?   ?   A . n 
A 1 440 GLU 440 440 ?   ?   ?   A . n 
A 1 441 ASP 441 441 ?   ?   ?   A . n 
A 1 442 GLY 442 442 ?   ?   ?   A . n 
A 1 443 GLU 443 443 ?   ?   ?   A . n 
A 1 444 SER 444 444 ?   ?   ?   A . n 
A 1 445 ASP 445 445 ?   ?   ?   A . n 
A 1 446 THR 446 446 ?   ?   ?   A . n 
A 1 447 GLU 447 447 ?   ?   ?   A . n 
A 1 448 LYS 448 448 ?   ?   ?   A . n 
A 1 449 ASP 449 449 ?   ?   ?   A . n 
A 1 450 SER 450 450 ?   ?   ?   A . n 
A 1 451 GLY 451 451 ?   ?   ?   A . n 
A 1 452 SER 452 452 ?   ?   ?   A . n 
A 1 453 GLN 453 453 ?   ?   ?   A . n 
A 1 454 VAL 454 454 ?   ?   ?   A . n 
A 1 455 GLU 455 455 ?   ?   ?   A . n 
A 1 456 GLU 456 456 ?   ?   ?   A . n 
A 1 457 ASP 457 457 ?   ?   ?   A . n 
A 1 458 THR 458 458 ?   ?   ?   A . n 
A 1 459 SER 459 459 ?   ?   ?   A . n 
A 1 460 CYS 460 460 ?   ?   ?   A . n 
A 1 461 SER 461 461 ?   ?   ?   A . n 
A 1 462 ASP 462 462 ?   ?   ?   A . n 
A 1 463 SER 463 463 ?   ?   ?   A . n 
A 1 464 LYS 464 464 ?   ?   ?   A . n 
A 1 465 THR 465 465 ?   ?   ?   A . n 
A 1 466 LEU 466 466 ?   ?   ?   A . n 
A 1 467 CYS 467 467 ?   ?   ?   A . n 
A 1 468 THR 468 468 ?   ?   ?   A . n 
A 1 469 GLN 469 469 ?   ?   ?   A . n 
A 1 470 ASP 470 470 ?   ?   ?   A . n 
A 1 471 SER 471 471 ?   ?   ?   A . n 
A 1 472 GLU 472 472 ?   ?   ?   A . n 
A 1 473 SER 473 473 ?   ?   ?   A . n 
A 1 474 THR 474 474 ?   ?   ?   A . n 
A 1 475 GLU 475 475 ?   ?   ?   A . n 
A 1 476 ILE 476 476 ?   ?   ?   A . n 
A 1 477 PRO 477 477 ?   ?   ?   A . n 
A 1 478 LEU 478 478 ?   ?   ?   A . n 
A 1 479 ASP 479 479 ?   ?   ?   A . n 
A 1 480 GLU 480 480 ?   ?   ?   A . n 
A 1 481 GLN 481 481 ?   ?   ?   A . n 
A 1 482 VAL 482 482 ?   ?   ?   A . n 
A 1 483 GLU 483 483 ?   ?   ?   A . n 
A 1 484 GLU 484 484 ?   ?   ?   A . n 
A 1 485 GLU 485 485 ?   ?   ?   A . n 
A 1 486 ALA 486 486 ?   ?   ?   A . n 
A 1 487 VAL 487 487 ?   ?   ?   A . n 
A 1 488 GLY 488 488 ?   ?   ?   A . n 
A 1 489 GLU 489 489 ?   ?   ?   A . n 
A 1 490 GLU 490 490 ?   ?   ?   A . n 
A 1 491 GLU 491 491 ?   ?   ?   A . n 
A 1 492 GLU 492 492 ?   ?   ?   A . n 
A 1 493 SER 493 493 ?   ?   ?   A . n 
A 1 494 GLN 494 494 ?   ?   ?   A . n 
A 1 495 PRO 495 495 ?   ?   ?   A . n 
A 1 496 GLU 496 496 ?   ?   ?   A . n 
A 1 497 ALA 497 497 ?   ?   ?   A . n 
A 1 498 CYS 498 498 ?   ?   ?   A . n 
A 1 499 VAL 499 499 ?   ?   ?   A . n 
A 1 500 ILE 500 500 ?   ?   ?   A . n 
A 1 501 ASP 501 501 ?   ?   ?   A . n 
A 1 502 ASP 502 502 ?   ?   ?   A . n 
A 1 503 ARG 503 503 ?   ?   ?   A . n 
A 1 504 SER 504 504 ?   ?   ?   A . n 
A 1 505 PRO 505 505 ?   ?   ?   A . n 
A 1 506 ASP 506 506 ?   ?   ?   A . n 
B 1 1   MET 1   1   ?   ?   ?   B . n 
B 1 2   ALA 2   2   ?   ?   ?   B . n 
B 1 3   SER 3   3   ?   ?   ?   B . n 
B 1 4   ASN 4   4   ?   ?   ?   B . n 
B 1 5   LYS 5   5   ?   ?   ?   B . n 
B 1 6   PHE 6   6   ?   ?   ?   B . n 
B 1 7   LYS 7   7   ?   ?   ?   B . n 
B 1 8   ARG 8   8   ?   ?   ?   B . n 
B 1 9   MET 9   9   ?   ?   ?   B . n 
B 1 10  LEU 10  10  ?   ?   ?   B . n 
B 1 11  ASN 11  11  ?   ?   ?   B . n 
B 1 12  ARG 12  12  ?   ?   ?   B . n 
B 1 13  GLU 13  13  ?   ?   ?   B . n 
B 1 14  LEU 14  14  ?   ?   ?   B . n 
B 1 15  THR 15  15  ?   ?   ?   B . n 
B 1 16  HIS 16  16  ?   ?   ?   B . n 
B 1 17  LEU 17  17  ?   ?   ?   B . n 
B 1 18  SER 18  18  ?   ?   ?   B . n 
B 1 19  GLU 19  19  ?   ?   ?   B . n 
B 1 20  MET 20  20  ?   ?   ?   B . n 
B 1 21  SER 21  21  ?   ?   ?   B . n 
B 1 22  ARG 22  22  ?   ?   ?   B . n 
B 1 23  SER 23  23  ?   ?   ?   B . n 
B 1 24  GLY 24  24  ?   ?   ?   B . n 
B 1 25  ASN 25  25  ?   ?   ?   B . n 
B 1 26  GLN 26  26  ?   ?   ?   B . n 
B 1 27  VAL 27  27  ?   ?   ?   B . n 
B 1 28  SER 28  28  ?   ?   ?   B . n 
B 1 29  GLU 29  29  ?   ?   ?   B . n 
B 1 30  PHE 30  30  ?   ?   ?   B . n 
B 1 31  ILE 31  31  ?   ?   ?   B . n 
B 1 32  SER 32  32  ?   ?   ?   B . n 
B 1 33  ASN 33  33  ?   ?   ?   B . n 
B 1 34  THR 34  34  ?   ?   ?   B . n 
B 1 35  PHE 35  35  ?   ?   ?   B . n 
B 1 36  LEU 36  36  ?   ?   ?   B . n 
B 1 37  ASP 37  37  ?   ?   ?   B . n 
B 1 38  LYS 38  38  ?   ?   ?   B . n 
B 1 39  GLN 39  39  ?   ?   ?   B . n 
B 1 40  HIS 40  40  ?   ?   ?   B . n 
B 1 41  GLU 41  41  ?   ?   ?   B . n 
B 1 42  VAL 42  42  ?   ?   ?   B . n 
B 1 43  GLU 43  43  ?   ?   ?   B . n 
B 1 44  ILE 44  44  ?   ?   ?   B . n 
B 1 45  PRO 45  45  ?   ?   ?   B . n 
B 1 46  SER 46  46  ?   ?   ?   B . n 
B 1 47  PRO 47  47  ?   ?   ?   B . n 
B 1 48  THR 48  48  ?   ?   ?   B . n 
B 1 49  GLN 49  49  ?   ?   ?   B . n 
B 1 50  LYS 50  50  ?   ?   ?   B . n 
B 1 51  GLU 51  51  ?   ?   ?   B . n 
B 1 52  LYS 52  52  ?   ?   ?   B . n 
B 1 53  GLU 53  53  ?   ?   ?   B . n 
B 1 54  LYS 54  54  ?   ?   ?   B . n 
B 1 55  LYS 55  55  ?   ?   ?   B . n 
B 1 56  LYS 56  56  ?   ?   ?   B . n 
B 1 57  ARG 57  57  ?   ?   ?   B . n 
B 1 58  PRO 58  58  ?   ?   ?   B . n 
B 1 59  MET 59  59  ?   ?   ?   B . n 
B 1 60  SER 60  60  ?   ?   ?   B . n 
B 1 61  GLN 61  61  ?   ?   ?   B . n 
B 1 62  ILE 62  62  ?   ?   ?   B . n 
B 1 63  SER 63  63  ?   ?   ?   B . n 
B 1 64  GLY 64  64  ?   ?   ?   B . n 
B 1 65  VAL 65  65  ?   ?   ?   B . n 
B 1 66  LYS 66  66  ?   ?   ?   B . n 
B 1 67  LYS 67  67  ?   ?   ?   B . n 
B 1 68  LEU 68  68  ?   ?   ?   B . n 
B 1 69  MET 69  69  ?   ?   ?   B . n 
B 1 70  HIS 70  70  ?   ?   ?   B . n 
B 1 71  SER 71  71  ?   ?   ?   B . n 
B 1 72  SER 72  72  ?   ?   ?   B . n 
B 1 73  SER 73  73  ?   ?   ?   B . n 
B 1 74  LEU 74  74  ?   ?   ?   B . n 
B 1 75  THR 75  75  ?   ?   ?   B . n 
B 1 76  ASN 76  76  ?   ?   ?   B . n 
B 1 77  SER 77  77  ?   ?   ?   B . n 
B 1 78  SER 78  78  ?   ?   ?   B . n 
B 1 79  ILE 79  79  ?   ?   ?   B . n 
B 1 80  PRO 80  80  ?   ?   ?   B . n 
B 1 81  ARG 81  81  ?   ?   ?   B . n 
B 1 82  PHE 82  82  ?   ?   ?   B . n 
B 1 83  GLY 83  83  ?   ?   ?   B . n 
B 1 84  VAL 84  84  ?   ?   ?   B . n 
B 1 85  LYS 85  85  ?   ?   ?   B . n 
B 1 86  THR 86  86  ?   ?   ?   B . n 
B 1 87  GLU 87  87  ?   ?   ?   B . n 
B 1 88  GLN 88  88  ?   ?   ?   B . n 
B 1 89  GLU 89  89  ?   ?   ?   B . n 
B 1 90  ASP 90  90  ?   ?   ?   B . n 
B 1 91  VAL 91  91  91  VAL VAL B . n 
B 1 92  LEU 92  92  92  LEU LEU B . n 
B 1 93  ALA 93  93  93  ALA ALA B . n 
B 1 94  LYS 94  94  94  LYS LYS B . n 
B 1 95  GLU 95  95  95  GLU GLU B . n 
B 1 96  LEU 96  96  96  LEU LEU B . n 
B 1 97  GLU 97  97  97  GLU GLU B . n 
B 1 98  ASP 98  98  98  ASP ASP B . n 
B 1 99  VAL 99  99  99  VAL VAL B . n 
B 1 100 ASN 100 100 100 ASN ASN B . n 
B 1 101 LYS 101 101 101 LYS LYS B . n 
B 1 102 TRP 102 102 102 TRP TRP B . n 
B 1 103 GLY 103 103 103 GLY GLY B . n 
B 1 104 LEU 104 104 104 LEU LEU B . n 
B 1 105 HIS 105 105 105 HIS HIS B . n 
B 1 106 VAL 106 106 106 VAL VAL B . n 
B 1 107 PHE 107 107 107 PHE PHE B . n 
B 1 108 ARG 108 108 108 ARG ARG B . n 
B 1 109 ILE 109 109 109 ILE ILE B . n 
B 1 110 ALA 110 110 110 ALA ALA B . n 
B 1 111 GLU 111 111 111 GLU GLU B . n 
B 1 112 LEU 112 112 112 LEU LEU B . n 
B 1 113 SER 113 113 113 SER SER B . n 
B 1 114 GLY 114 114 114 GLY GLY B . n 
B 1 115 ASN 115 115 115 ASN ASN B . n 
B 1 116 ARG 116 116 116 ARG ARG B . n 
B 1 117 PRO 117 117 117 PRO PRO B . n 
B 1 118 LEU 118 118 118 LEU LEU B . n 
B 1 119 THR 119 119 119 THR THR B . n 
B 1 120 VAL 120 120 120 VAL VAL B . n 
B 1 121 ILE 121 121 121 ILE ILE B . n 
B 1 122 MET 122 122 122 MET MET B . n 
B 1 123 HIS 123 123 123 HIS HIS B . n 
B 1 124 THR 124 124 124 THR THR B . n 
B 1 125 ILE 125 125 125 ILE ILE B . n 
B 1 126 PHE 126 126 126 PHE PHE B . n 
B 1 127 GLN 127 127 127 GLN GLN B . n 
B 1 128 GLU 128 128 128 GLU GLU B . n 
B 1 129 ARG 129 129 129 ARG ARG B . n 
B 1 130 ASP 130 130 130 ASP ASP B . n 
B 1 131 LEU 131 131 131 LEU LEU B . n 
B 1 132 LEU 132 132 132 LEU LEU B . n 
B 1 133 LYS 133 133 133 LYS LYS B . n 
B 1 134 THR 134 134 134 THR THR B . n 
B 1 135 PHE 135 135 135 PHE PHE B . n 
B 1 136 LYS 136 136 136 LYS LYS B . n 
B 1 137 ILE 137 137 137 ILE ILE B . n 
B 1 138 PRO 138 138 138 PRO PRO B . n 
B 1 139 VAL 139 139 139 VAL VAL B . n 
B 1 140 ASP 140 140 140 ASP ASP B . n 
B 1 141 THR 141 141 141 THR THR B . n 
B 1 142 LEU 142 142 142 LEU LEU B . n 
B 1 143 ILE 143 143 143 ILE ILE B . n 
B 1 144 THR 144 144 144 THR THR B . n 
B 1 145 TYR 145 145 145 TYR TYR B . n 
B 1 146 LEU 146 146 146 LEU LEU B . n 
B 1 147 MET 147 147 147 MET MET B . n 
B 1 148 THR 148 148 148 THR THR B . n 
B 1 149 LEU 149 149 149 LEU LEU B . n 
B 1 150 GLU 150 150 150 GLU GLU B . n 
B 1 151 ASP 151 151 151 ASP ASP B . n 
B 1 152 HIS 152 152 152 HIS HIS B . n 
B 1 153 TYR 153 153 153 TYR TYR B . n 
B 1 154 HIS 154 154 154 HIS HIS B . n 
B 1 155 ALA 155 155 155 ALA ALA B . n 
B 1 156 ASP 156 156 156 ASP ASP B . n 
B 1 157 VAL 157 157 157 VAL VAL B . n 
B 1 158 ALA 158 158 158 ALA ALA B . n 
B 1 159 TYR 159 159 159 TYR TYR B . n 
B 1 160 HIS 160 160 160 HIS HIS B . n 
B 1 161 ASN 161 161 161 ASN ASN B . n 
B 1 162 ASN 162 162 162 ASN ASN B . n 
B 1 163 ILE 163 163 163 ILE ILE B . n 
B 1 164 HIS 164 164 164 HIS HIS B . n 
B 1 165 ALA 165 165 165 ALA ALA B . n 
B 1 166 ALA 166 166 166 ALA ALA B . n 
B 1 167 ASP 167 167 167 ASP ASP B . n 
B 1 168 VAL 168 168 168 VAL VAL B . n 
B 1 169 VAL 169 169 169 VAL VAL B . n 
B 1 170 GLN 170 170 170 GLN GLN B . n 
B 1 171 SER 171 171 171 SER SER B . n 
B 1 172 THR 172 172 172 THR THR B . n 
B 1 173 HIS 173 173 173 HIS HIS B . n 
B 1 174 VAL 174 174 174 VAL VAL B . n 
B 1 175 LEU 175 175 175 LEU LEU B . n 
B 1 176 LEU 176 176 176 LEU LEU B . n 
B 1 177 SER 177 177 177 SER SER B . n 
B 1 178 THR 178 178 178 THR THR B . n 
B 1 179 PRO 179 179 179 PRO PRO B . n 
B 1 180 ALA 180 180 180 ALA ALA B . n 
B 1 181 LEU 181 181 181 LEU LEU B . n 
B 1 182 GLU 182 182 182 GLU GLU B . n 
B 1 183 ALA 183 183 183 ALA ALA B . n 
B 1 184 VAL 184 184 184 VAL VAL B . n 
B 1 185 PHE 185 185 185 PHE PHE B . n 
B 1 186 THR 186 186 186 THR THR B . n 
B 1 187 ASP 187 187 187 ASP ASP B . n 
B 1 188 LEU 188 188 188 LEU LEU B . n 
B 1 189 GLU 189 189 189 GLU GLU B . n 
B 1 190 ILE 190 190 190 ILE ILE B . n 
B 1 191 LEU 191 191 191 LEU LEU B . n 
B 1 192 ALA 192 192 192 ALA ALA B . n 
B 1 193 ALA 193 193 193 ALA ALA B . n 
B 1 194 ILE 194 194 194 ILE ILE B . n 
B 1 195 PHE 195 195 195 PHE PHE B . n 
B 1 196 ALA 196 196 196 ALA ALA B . n 
B 1 197 SER 197 197 197 SER SER B . n 
B 1 198 ALA 198 198 198 ALA ALA B . n 
B 1 199 ILE 199 199 199 ILE ILE B . n 
B 1 200 HIS 200 200 200 HIS HIS B . n 
B 1 201 ASP 201 201 201 ASP ASP B . n 
B 1 202 VAL 202 202 202 VAL VAL B . n 
B 1 203 ASP 203 203 203 ASP ASP B . n 
B 1 204 HIS 204 204 204 HIS HIS B . n 
B 1 205 PRO 205 205 205 PRO PRO B . n 
B 1 206 GLY 206 206 206 GLY GLY B . n 
B 1 207 VAL 207 207 207 VAL VAL B . n 
B 1 208 SER 208 208 208 SER SER B . n 
B 1 209 ASN 209 209 209 ASN ASN B . n 
B 1 210 GLN 210 210 210 GLN GLN B . n 
B 1 211 PHE 211 211 211 PHE PHE B . n 
B 1 212 LEU 212 212 212 LEU LEU B . n 
B 1 213 ILE 213 213 213 ILE ILE B . n 
B 1 214 ASN 214 214 214 ASN ASN B . n 
B 1 215 THR 215 215 215 THR THR B . n 
B 1 216 ASN 216 216 216 ASN ASN B . n 
B 1 217 SER 217 217 217 SER SER B . n 
B 1 218 GLU 218 218 218 GLU GLU B . n 
B 1 219 LEU 219 219 219 LEU LEU B . n 
B 1 220 ALA 220 220 220 ALA ALA B . n 
B 1 221 LEU 221 221 221 LEU LEU B . n 
B 1 222 MET 222 222 222 MET MET B . n 
B 1 223 TYR 223 223 223 TYR TYR B . n 
B 1 224 ASN 224 224 224 ASN ASN B . n 
B 1 225 ASP 225 225 225 ASP ASP B . n 
B 1 226 SER 226 226 226 SER SER B . n 
B 1 227 SER 227 227 227 SER SER B . n 
B 1 228 VAL 228 228 228 VAL VAL B . n 
B 1 229 LEU 229 229 229 LEU LEU B . n 
B 1 230 GLU 230 230 230 GLU GLU B . n 
B 1 231 ASN 231 231 231 ASN ASN B . n 
B 1 232 HIS 232 232 232 HIS HIS B . n 
B 1 233 HIS 233 233 233 HIS HIS B . n 
B 1 234 LEU 234 234 234 LEU LEU B . n 
B 1 235 ALA 235 235 235 ALA ALA B . n 
B 1 236 VAL 236 236 236 VAL VAL B . n 
B 1 237 GLY 237 237 237 GLY GLY B . n 
B 1 238 PHE 238 238 238 PHE PHE B . n 
B 1 239 LYS 239 239 239 LYS LYS B . n 
B 1 240 LEU 240 240 240 LEU LEU B . n 
B 1 241 LEU 241 241 241 LEU LEU B . n 
B 1 242 GLN 242 242 242 GLN GLN B . n 
B 1 243 GLU 243 243 243 GLU GLU B . n 
B 1 244 GLU 244 244 244 GLU GLU B . n 
B 1 245 ASN 245 245 245 ASN ASN B . n 
B 1 246 CYS 246 246 246 CYS CYS B . n 
B 1 247 ASP 247 247 247 ASP ASP B . n 
B 1 248 ILE 248 248 248 ILE ILE B . n 
B 1 249 PHE 249 249 249 PHE PHE B . n 
B 1 250 GLN 250 250 250 GLN GLN B . n 
B 1 251 ASN 251 251 251 ASN ASN B . n 
B 1 252 LEU 252 252 252 LEU LEU B . n 
B 1 253 THR 253 253 253 THR THR B . n 
B 1 254 LYS 254 254 254 LYS LYS B . n 
B 1 255 LYS 255 255 255 LYS LYS B . n 
B 1 256 GLN 256 256 256 GLN GLN B . n 
B 1 257 ARG 257 257 257 ARG ARG B . n 
B 1 258 GLN 258 258 258 GLN GLN B . n 
B 1 259 SER 259 259 259 SER SER B . n 
B 1 260 LEU 260 260 260 LEU LEU B . n 
B 1 261 ARG 261 261 261 ARG ARG B . n 
B 1 262 LYS 262 262 262 LYS LYS B . n 
B 1 263 MET 263 263 263 MET MET B . n 
B 1 264 VAL 264 264 264 VAL VAL B . n 
B 1 265 ILE 265 265 265 ILE ILE B . n 
B 1 266 ASP 266 266 266 ASP ASP B . n 
B 1 267 ILE 267 267 267 ILE ILE B . n 
B 1 268 VAL 268 268 268 VAL VAL B . n 
B 1 269 LEU 269 269 269 LEU LEU B . n 
B 1 270 ALA 270 270 270 ALA ALA B . n 
B 1 271 THR 271 271 271 THR THR B . n 
B 1 272 ASP 272 272 272 ASP ASP B . n 
B 1 273 MET 273 273 273 MET MET B . n 
B 1 274 SER 274 274 274 SER SER B . n 
B 1 275 LYS 275 275 275 LYS LYS B . n 
B 1 276 HIS 276 276 276 HIS HIS B . n 
B 1 277 MET 277 277 277 MET MET B . n 
B 1 278 ASN 278 278 278 ASN ASN B . n 
B 1 279 LEU 279 279 279 LEU LEU B . n 
B 1 280 LEU 280 280 280 LEU LEU B . n 
B 1 281 ALA 281 281 281 ALA ALA B . n 
B 1 282 ASP 282 282 282 ASP ASP B . n 
B 1 283 LEU 283 283 283 LEU LEU B . n 
B 1 284 LYS 284 284 284 LYS LYS B . n 
B 1 285 THR 285 285 285 THR THR B . n 
B 1 286 MET 286 286 286 MET MET B . n 
B 1 287 VAL 287 287 287 VAL VAL B . n 
B 1 288 GLU 288 288 288 GLU GLU B . n 
B 1 289 THR 289 289 289 THR THR B . n 
B 1 290 LYS 290 290 290 LYS LYS B . n 
B 1 291 LYS 291 291 291 LYS LYS B . n 
B 1 292 VAL 292 292 292 VAL VAL B . n 
B 1 293 THR 293 293 293 THR THR B . n 
B 1 294 SER 294 294 294 SER SER B . n 
B 1 295 SER 295 295 295 SER SER B . n 
B 1 296 GLY 296 296 296 GLY GLY B . n 
B 1 297 VAL 297 297 297 VAL VAL B . n 
B 1 298 LEU 298 298 298 LEU LEU B . n 
B 1 299 LEU 299 299 299 LEU LEU B . n 
B 1 300 LEU 300 300 300 LEU LEU B . n 
B 1 301 ASP 301 301 301 ASP ASP B . n 
B 1 302 ASN 302 302 302 ASN ASN B . n 
B 1 303 TYR 303 303 303 TYR TYR B . n 
B 1 304 SER 304 304 304 SER SER B . n 
B 1 305 ASP 305 305 305 ASP ASP B . n 
B 1 306 ARG 306 306 306 ARG ARG B . n 
B 1 307 ILE 307 307 307 ILE ILE B . n 
B 1 308 GLN 308 308 308 GLN GLN B . n 
B 1 309 VAL 309 309 309 VAL VAL B . n 
B 1 310 LEU 310 310 310 LEU LEU B . n 
B 1 311 GLN 311 311 311 GLN GLN B . n 
B 1 312 ASN 312 312 312 ASN ASN B . n 
B 1 313 MET 313 313 313 MET MET B . n 
B 1 314 VAL 314 314 314 VAL VAL B . n 
B 1 315 HIS 315 315 315 HIS HIS B . n 
B 1 316 CYS 316 316 316 CYS CYS B . n 
B 1 317 ALA 317 317 317 ALA ALA B . n 
B 1 318 ASP 318 318 318 ASP ASP B . n 
B 1 319 LEU 319 319 319 LEU LEU B . n 
B 1 320 SER 320 320 320 SER SER B . n 
B 1 321 ASN 321 321 321 ASN ASN B . n 
B 1 322 PRO 322 322 322 PRO PRO B . n 
B 1 323 THR 323 323 323 THR THR B . n 
B 1 324 LYS 324 324 324 LYS LYS B . n 
B 1 325 PRO 325 325 325 PRO PRO B . n 
B 1 326 LEU 326 326 326 LEU LEU B . n 
B 1 327 GLN 327 327 327 GLN GLN B . n 
B 1 328 LEU 328 328 328 LEU LEU B . n 
B 1 329 TYR 329 329 329 TYR TYR B . n 
B 1 330 ARG 330 330 330 ARG ARG B . n 
B 1 331 GLN 331 331 331 GLN GLN B . n 
B 1 332 TRP 332 332 332 TRP TRP B . n 
B 1 333 THR 333 333 333 THR THR B . n 
B 1 334 ASP 334 334 334 ASP ASP B . n 
B 1 335 ARG 335 335 335 ARG ARG B . n 
B 1 336 ILE 336 336 336 ILE ILE B . n 
B 1 337 MET 337 337 337 MET MET B . n 
B 1 338 GLU 338 338 338 GLU GLU B . n 
B 1 339 GLU 339 339 339 GLU GLU B . n 
B 1 340 PHE 340 340 340 PHE PHE B . n 
B 1 341 PHE 341 341 341 PHE PHE B . n 
B 1 342 ARG 342 342 342 ARG ARG B . n 
B 1 343 GLN 343 343 343 GLN GLN B . n 
B 1 344 GLY 344 344 344 GLY GLY B . n 
B 1 345 ASP 345 345 345 ASP ASP B . n 
B 1 346 ARG 346 346 346 ARG ARG B . n 
B 1 347 GLU 347 347 347 GLU GLU B . n 
B 1 348 ARG 348 348 348 ARG ARG B . n 
B 1 349 GLU 349 349 349 GLU GLU B . n 
B 1 350 ARG 350 350 350 ARG ARG B . n 
B 1 351 GLY 351 351 351 GLY GLY B . n 
B 1 352 MET 352 352 352 MET MET B . n 
B 1 353 GLU 353 353 353 GLU GLU B . n 
B 1 354 ILE 354 354 354 ILE ILE B . n 
B 1 355 SER 355 355 355 SER SER B . n 
B 1 356 PRO 356 356 356 PRO PRO B . n 
B 1 357 MET 357 357 357 MET MET B . n 
B 1 358 CYS 358 358 358 CYS CYS B . n 
B 1 359 ASP 359 359 359 ASP ASP B . n 
B 1 360 LYS 360 360 360 LYS LYS B . n 
B 1 361 HIS 361 361 361 HIS HIS B . n 
B 1 362 ASN 362 362 362 ASN ASN B . n 
B 1 363 ALA 363 363 363 ALA ALA B . n 
B 1 364 SER 364 364 364 SER SER B . n 
B 1 365 VAL 365 365 365 VAL VAL B . n 
B 1 366 GLU 366 366 366 GLU GLU B . n 
B 1 367 LYS 367 367 367 LYS LYS B . n 
B 1 368 SER 368 368 368 SER SER B . n 
B 1 369 GLN 369 369 369 GLN GLN B . n 
B 1 370 VAL 370 370 370 VAL VAL B . n 
B 1 371 GLY 371 371 371 GLY GLY B . n 
B 1 372 PHE 372 372 372 PHE PHE B . n 
B 1 373 ILE 373 373 373 ILE ILE B . n 
B 1 374 ASP 374 374 374 ASP ASP B . n 
B 1 375 TYR 375 375 375 TYR TYR B . n 
B 1 376 ILE 376 376 376 ILE ILE B . n 
B 1 377 VAL 377 377 377 VAL VAL B . n 
B 1 378 HIS 378 378 378 HIS HIS B . n 
B 1 379 PRO 379 379 379 PRO PRO B . n 
B 1 380 LEU 380 380 380 LEU LEU B . n 
B 1 381 TRP 381 381 381 TRP TRP B . n 
B 1 382 GLU 382 382 382 GLU GLU B . n 
B 1 383 THR 383 383 383 THR THR B . n 
B 1 384 TRP 384 384 384 TRP TRP B . n 
B 1 385 ALA 385 385 385 ALA ALA B . n 
B 1 386 ASP 386 386 386 ASP ASP B . n 
B 1 387 LEU 387 387 387 LEU LEU B . n 
B 1 388 VAL 388 388 388 VAL VAL B . n 
B 1 389 HIS 389 389 389 HIS HIS B . n 
B 1 390 PRO 390 390 390 PRO PRO B . n 
B 1 391 ASP 391 391 391 ASP ASP B . n 
B 1 392 ALA 392 392 392 ALA ALA B . n 
B 1 393 GLN 393 393 393 GLN GLN B . n 
B 1 394 ASP 394 394 394 ASP ASP B . n 
B 1 395 ILE 395 395 395 ILE ILE B . n 
B 1 396 LEU 396 396 396 LEU LEU B . n 
B 1 397 ASP 397 397 397 ASP ASP B . n 
B 1 398 THR 398 398 398 THR THR B . n 
B 1 399 LEU 399 399 399 LEU LEU B . n 
B 1 400 GLU 400 400 400 GLU GLU B . n 
B 1 401 ASP 401 401 401 ASP ASP B . n 
B 1 402 ASN 402 402 402 ASN ASN B . n 
B 1 403 ARG 403 403 403 ARG ARG B . n 
B 1 404 GLU 404 404 404 GLU GLU B . n 
B 1 405 TRP 405 405 405 TRP TRP B . n 
B 1 406 TYR 406 406 406 TYR TYR B . n 
B 1 407 GLN 407 407 407 GLN GLN B . n 
B 1 408 SER 408 408 408 SER SER B . n 
B 1 409 THR 409 409 409 THR THR B . n 
B 1 410 ILE 410 410 410 ILE ILE B . n 
B 1 411 PRO 411 411 411 PRO PRO B . n 
B 1 412 GLN 412 412 ?   ?   ?   B . n 
B 1 413 SER 413 413 ?   ?   ?   B . n 
B 1 414 PRO 414 414 ?   ?   ?   B . n 
B 1 415 SER 415 415 ?   ?   ?   B . n 
B 1 416 PRO 416 416 ?   ?   ?   B . n 
B 1 417 ALA 417 417 ?   ?   ?   B . n 
B 1 418 PRO 418 418 ?   ?   ?   B . n 
B 1 419 ASP 419 419 ?   ?   ?   B . n 
B 1 420 ASP 420 420 ?   ?   ?   B . n 
B 1 421 PRO 421 421 ?   ?   ?   B . n 
B 1 422 GLU 422 422 ?   ?   ?   B . n 
B 1 423 GLU 423 423 ?   ?   ?   B . n 
B 1 424 GLY 424 424 ?   ?   ?   B . n 
B 1 425 ARG 425 425 ?   ?   ?   B . n 
B 1 426 GLN 426 426 ?   ?   ?   B . n 
B 1 427 GLY 427 427 ?   ?   ?   B . n 
B 1 428 GLN 428 428 ?   ?   ?   B . n 
B 1 429 THR 429 429 ?   ?   ?   B . n 
B 1 430 GLU 430 430 ?   ?   ?   B . n 
B 1 431 LYS 431 431 ?   ?   ?   B . n 
B 1 432 PHE 432 432 ?   ?   ?   B . n 
B 1 433 GLN 433 433 ?   ?   ?   B . n 
B 1 434 PHE 434 434 ?   ?   ?   B . n 
B 1 435 GLU 435 435 ?   ?   ?   B . n 
B 1 436 LEU 436 436 ?   ?   ?   B . n 
B 1 437 THR 437 437 ?   ?   ?   B . n 
B 1 438 LEU 438 438 ?   ?   ?   B . n 
B 1 439 GLU 439 439 ?   ?   ?   B . n 
B 1 440 GLU 440 440 ?   ?   ?   B . n 
B 1 441 ASP 441 441 ?   ?   ?   B . n 
B 1 442 GLY 442 442 ?   ?   ?   B . n 
B 1 443 GLU 443 443 ?   ?   ?   B . n 
B 1 444 SER 444 444 ?   ?   ?   B . n 
B 1 445 ASP 445 445 ?   ?   ?   B . n 
B 1 446 THR 446 446 ?   ?   ?   B . n 
B 1 447 GLU 447 447 ?   ?   ?   B . n 
B 1 448 LYS 448 448 ?   ?   ?   B . n 
B 1 449 ASP 449 449 ?   ?   ?   B . n 
B 1 450 SER 450 450 ?   ?   ?   B . n 
B 1 451 GLY 451 451 ?   ?   ?   B . n 
B 1 452 SER 452 452 ?   ?   ?   B . n 
B 1 453 GLN 453 453 ?   ?   ?   B . n 
B 1 454 VAL 454 454 ?   ?   ?   B . n 
B 1 455 GLU 455 455 ?   ?   ?   B . n 
B 1 456 GLU 456 456 ?   ?   ?   B . n 
B 1 457 ASP 457 457 ?   ?   ?   B . n 
B 1 458 THR 458 458 ?   ?   ?   B . n 
B 1 459 SER 459 459 ?   ?   ?   B . n 
B 1 460 CYS 460 460 ?   ?   ?   B . n 
B 1 461 SER 461 461 ?   ?   ?   B . n 
B 1 462 ASP 462 462 ?   ?   ?   B . n 
B 1 463 SER 463 463 ?   ?   ?   B . n 
B 1 464 LYS 464 464 ?   ?   ?   B . n 
B 1 465 THR 465 465 ?   ?   ?   B . n 
B 1 466 LEU 466 466 ?   ?   ?   B . n 
B 1 467 CYS 467 467 ?   ?   ?   B . n 
B 1 468 THR 468 468 ?   ?   ?   B . n 
B 1 469 GLN 469 469 ?   ?   ?   B . n 
B 1 470 ASP 470 470 ?   ?   ?   B . n 
B 1 471 SER 471 471 ?   ?   ?   B . n 
B 1 472 GLU 472 472 ?   ?   ?   B . n 
B 1 473 SER 473 473 ?   ?   ?   B . n 
B 1 474 THR 474 474 ?   ?   ?   B . n 
B 1 475 GLU 475 475 ?   ?   ?   B . n 
B 1 476 ILE 476 476 ?   ?   ?   B . n 
B 1 477 PRO 477 477 ?   ?   ?   B . n 
B 1 478 LEU 478 478 ?   ?   ?   B . n 
B 1 479 ASP 479 479 ?   ?   ?   B . n 
B 1 480 GLU 480 480 ?   ?   ?   B . n 
B 1 481 GLN 481 481 ?   ?   ?   B . n 
B 1 482 VAL 482 482 ?   ?   ?   B . n 
B 1 483 GLU 483 483 ?   ?   ?   B . n 
B 1 484 GLU 484 484 ?   ?   ?   B . n 
B 1 485 GLU 485 485 ?   ?   ?   B . n 
B 1 486 ALA 486 486 ?   ?   ?   B . n 
B 1 487 VAL 487 487 ?   ?   ?   B . n 
B 1 488 GLY 488 488 ?   ?   ?   B . n 
B 1 489 GLU 489 489 ?   ?   ?   B . n 
B 1 490 GLU 490 490 ?   ?   ?   B . n 
B 1 491 GLU 491 491 ?   ?   ?   B . n 
B 1 492 GLU 492 492 ?   ?   ?   B . n 
B 1 493 SER 493 493 ?   ?   ?   B . n 
B 1 494 GLN 494 494 ?   ?   ?   B . n 
B 1 495 PRO 495 495 ?   ?   ?   B . n 
B 1 496 GLU 496 496 ?   ?   ?   B . n 
B 1 497 ALA 497 497 ?   ?   ?   B . n 
B 1 498 CYS 498 498 ?   ?   ?   B . n 
B 1 499 VAL 499 499 ?   ?   ?   B . n 
B 1 500 ILE 500 500 ?   ?   ?   B . n 
B 1 501 ASP 501 501 ?   ?   ?   B . n 
B 1 502 ASP 502 502 ?   ?   ?   B . n 
B 1 503 ARG 503 503 ?   ?   ?   B . n 
B 1 504 SER 504 504 ?   ?   ?   B . n 
B 1 505 PRO 505 505 ?   ?   ?   B . n 
B 1 506 ASP 506 506 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1EKX 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1EKX 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 ZN    1   601 1   ZN    ZN  A . 
D 3 MG    1   602 1   MG    MG  A . 
E 4 A1EKX 1   603 1   A1EKX 231 A . 
F 2 ZN    1   601 2   ZN    ZN  B . 
G 3 MG    1   602 2   MG    MG  B . 
H 4 A1EKX 1   603 2   A1EKX 231 B . 
I 5 HOH   1   701 215 HOH   HOH A . 
I 5 HOH   2   702 2   HOH   HOH A . 
I 5 HOH   3   703 210 HOH   HOH A . 
I 5 HOH   4   704 169 HOH   HOH A . 
I 5 HOH   5   705 127 HOH   HOH A . 
I 5 HOH   6   706 184 HOH   HOH A . 
I 5 HOH   7   707 95  HOH   HOH A . 
I 5 HOH   8   708 218 HOH   HOH A . 
I 5 HOH   9   709 105 HOH   HOH A . 
I 5 HOH   10  710 139 HOH   HOH A . 
I 5 HOH   11  711 16  HOH   HOH A . 
I 5 HOH   12  712 4   HOH   HOH A . 
I 5 HOH   13  713 33  HOH   HOH A . 
I 5 HOH   14  714 28  HOH   HOH A . 
I 5 HOH   15  715 11  HOH   HOH A . 
I 5 HOH   16  716 143 HOH   HOH A . 
I 5 HOH   17  717 158 HOH   HOH A . 
I 5 HOH   18  718 186 HOH   HOH A . 
I 5 HOH   19  719 27  HOH   HOH A . 
I 5 HOH   20  720 133 HOH   HOH A . 
I 5 HOH   21  721 14  HOH   HOH A . 
I 5 HOH   22  722 32  HOH   HOH A . 
I 5 HOH   23  723 68  HOH   HOH A . 
I 5 HOH   24  724 5   HOH   HOH A . 
I 5 HOH   25  725 64  HOH   HOH A . 
I 5 HOH   26  726 191 HOH   HOH A . 
I 5 HOH   27  727 18  HOH   HOH A . 
I 5 HOH   28  728 2   HOH   HOH A . 
I 5 HOH   29  729 114 HOH   HOH A . 
I 5 HOH   30  730 23  HOH   HOH A . 
I 5 HOH   31  731 121 HOH   HOH A . 
I 5 HOH   32  732 37  HOH   HOH A . 
I 5 HOH   33  733 98  HOH   HOH A . 
I 5 HOH   34  734 164 HOH   HOH A . 
I 5 HOH   35  735 96  HOH   HOH A . 
I 5 HOH   36  736 1   HOH   HOH A . 
I 5 HOH   37  737 130 HOH   HOH A . 
I 5 HOH   38  738 20  HOH   HOH A . 
I 5 HOH   39  739 157 HOH   HOH A . 
I 5 HOH   40  740 6   HOH   HOH A . 
I 5 HOH   41  741 77  HOH   HOH A . 
I 5 HOH   42  742 199 HOH   HOH A . 
I 5 HOH   43  743 116 HOH   HOH A . 
I 5 HOH   44  744 78  HOH   HOH A . 
I 5 HOH   45  745 90  HOH   HOH A . 
I 5 HOH   46  746 111 HOH   HOH A . 
I 5 HOH   47  747 69  HOH   HOH A . 
I 5 HOH   48  748 209 HOH   HOH A . 
I 5 HOH   49  749 151 HOH   HOH A . 
I 5 HOH   50  750 200 HOH   HOH A . 
I 5 HOH   51  751 4   HOH   HOH A . 
I 5 HOH   52  752 1   HOH   HOH A . 
I 5 HOH   53  753 39  HOH   HOH A . 
I 5 HOH   54  754 54  HOH   HOH A . 
I 5 HOH   55  755 204 HOH   HOH A . 
I 5 HOH   56  756 47  HOH   HOH A . 
I 5 HOH   57  757 67  HOH   HOH A . 
I 5 HOH   58  758 263 HOH   HOH A . 
I 5 HOH   59  759 124 HOH   HOH A . 
I 5 HOH   60  760 24  HOH   HOH A . 
I 5 HOH   61  761 142 HOH   HOH A . 
I 5 HOH   62  762 60  HOH   HOH A . 
I 5 HOH   63  763 214 HOH   HOH A . 
I 5 HOH   64  764 122 HOH   HOH A . 
I 5 HOH   65  765 9   HOH   HOH A . 
I 5 HOH   66  766 189 HOH   HOH A . 
I 5 HOH   67  767 148 HOH   HOH A . 
I 5 HOH   68  768 237 HOH   HOH A . 
I 5 HOH   69  769 79  HOH   HOH A . 
I 5 HOH   70  770 223 HOH   HOH A . 
I 5 HOH   71  771 62  HOH   HOH A . 
I 5 HOH   72  772 63  HOH   HOH A . 
I 5 HOH   73  773 43  HOH   HOH A . 
I 5 HOH   74  774 154 HOH   HOH A . 
I 5 HOH   75  775 103 HOH   HOH A . 
I 5 HOH   76  776 203 HOH   HOH A . 
I 5 HOH   77  777 72  HOH   HOH A . 
I 5 HOH   78  778 125 HOH   HOH A . 
I 5 HOH   79  779 8   HOH   HOH A . 
I 5 HOH   80  780 173 HOH   HOH A . 
I 5 HOH   81  781 101 HOH   HOH A . 
I 5 HOH   82  782 59  HOH   HOH A . 
I 5 HOH   83  783 104 HOH   HOH A . 
I 5 HOH   84  784 19  HOH   HOH A . 
I 5 HOH   85  785 34  HOH   HOH A . 
I 5 HOH   86  786 15  HOH   HOH A . 
I 5 HOH   87  787 94  HOH   HOH A . 
I 5 HOH   88  788 3   HOH   HOH A . 
I 5 HOH   89  789 196 HOH   HOH A . 
I 5 HOH   90  790 170 HOH   HOH A . 
I 5 HOH   91  791 81  HOH   HOH A . 
I 5 HOH   92  792 176 HOH   HOH A . 
I 5 HOH   93  793 44  HOH   HOH A . 
I 5 HOH   94  794 138 HOH   HOH A . 
I 5 HOH   95  795 136 HOH   HOH A . 
I 5 HOH   96  796 155 HOH   HOH A . 
I 5 HOH   97  797 198 HOH   HOH A . 
I 5 HOH   98  798 207 HOH   HOH A . 
I 5 HOH   99  799 36  HOH   HOH A . 
I 5 HOH   100 800 65  HOH   HOH A . 
I 5 HOH   101 801 31  HOH   HOH A . 
I 5 HOH   102 802 144 HOH   HOH A . 
I 5 HOH   103 803 174 HOH   HOH A . 
I 5 HOH   104 804 100 HOH   HOH A . 
I 5 HOH   105 805 228 HOH   HOH A . 
I 5 HOH   106 806 222 HOH   HOH A . 
I 5 HOH   107 807 99  HOH   HOH A . 
I 5 HOH   108 808 50  HOH   HOH A . 
I 5 HOH   109 809 197 HOH   HOH A . 
I 5 HOH   110 810 192 HOH   HOH A . 
I 5 HOH   111 811 246 HOH   HOH A . 
I 5 HOH   112 812 86  HOH   HOH A . 
I 5 HOH   113 813 137 HOH   HOH A . 
I 5 HOH   114 814 177 HOH   HOH A . 
I 5 HOH   115 815 91  HOH   HOH A . 
I 5 HOH   116 816 221 HOH   HOH A . 
I 5 HOH   117 817 181 HOH   HOH A . 
I 5 HOH   118 818 258 HOH   HOH A . 
I 5 HOH   119 819 132 HOH   HOH A . 
I 5 HOH   120 820 230 HOH   HOH A . 
I 5 HOH   121 821 162 HOH   HOH A . 
I 5 HOH   122 822 48  HOH   HOH A . 
I 5 HOH   123 823 249 HOH   HOH A . 
I 5 HOH   124 824 166 HOH   HOH A . 
I 5 HOH   125 825 233 HOH   HOH A . 
I 5 HOH   126 826 267 HOH   HOH A . 
I 5 HOH   127 827 264 HOH   HOH A . 
I 5 HOH   128 828 234 HOH   HOH A . 
I 5 HOH   129 829 168 HOH   HOH A . 
I 5 HOH   130 830 140 HOH   HOH A . 
I 5 HOH   131 831 147 HOH   HOH A . 
I 5 HOH   132 832 206 HOH   HOH A . 
I 5 HOH   133 833 235 HOH   HOH A . 
I 5 HOH   134 834 241 HOH   HOH A . 
I 5 HOH   135 835 256 HOH   HOH A . 
I 5 HOH   136 836 201 HOH   HOH A . 
I 5 HOH   137 837 193 HOH   HOH A . 
I 5 HOH   138 838 242 HOH   HOH A . 
I 5 HOH   139 839 252 HOH   HOH A . 
I 5 HOH   140 840 245 HOH   HOH A . 
I 5 HOH   141 841 205 HOH   HOH A . 
I 5 HOH   142 842 190 HOH   HOH A . 
I 5 HOH   143 843 213 HOH   HOH A . 
I 5 HOH   144 844 248 HOH   HOH A . 
I 5 HOH   145 845 238 HOH   HOH A . 
I 5 HOH   146 846 255 HOH   HOH A . 
I 5 HOH   147 847 266 HOH   HOH A . 
J 5 HOH   1   701 88  HOH   HOH B . 
J 5 HOH   2   702 40  HOH   HOH B . 
J 5 HOH   3   703 120 HOH   HOH B . 
J 5 HOH   4   704 123 HOH   HOH B . 
J 5 HOH   5   705 10  HOH   HOH B . 
J 5 HOH   6   706 74  HOH   HOH B . 
J 5 HOH   7   707 82  HOH   HOH B . 
J 5 HOH   8   708 6   HOH   HOH B . 
J 5 HOH   9   709 29  HOH   HOH B . 
J 5 HOH   10  710 247 HOH   HOH B . 
J 5 HOH   11  711 17  HOH   HOH B . 
J 5 HOH   12  712 108 HOH   HOH B . 
J 5 HOH   13  713 12  HOH   HOH B . 
J 5 HOH   14  714 106 HOH   HOH B . 
J 5 HOH   15  715 8   HOH   HOH B . 
J 5 HOH   16  716 55  HOH   HOH B . 
J 5 HOH   17  717 7   HOH   HOH B . 
J 5 HOH   18  718 45  HOH   HOH B . 
J 5 HOH   19  719 93  HOH   HOH B . 
J 5 HOH   20  720 61  HOH   HOH B . 
J 5 HOH   21  721 66  HOH   HOH B . 
J 5 HOH   22  722 42  HOH   HOH B . 
J 5 HOH   23  723 7   HOH   HOH B . 
J 5 HOH   24  724 97  HOH   HOH B . 
J 5 HOH   25  725 87  HOH   HOH B . 
J 5 HOH   26  726 52  HOH   HOH B . 
J 5 HOH   27  727 119 HOH   HOH B . 
J 5 HOH   28  728 3   HOH   HOH B . 
J 5 HOH   29  729 217 HOH   HOH B . 
J 5 HOH   30  730 180 HOH   HOH B . 
J 5 HOH   31  731 80  HOH   HOH B . 
J 5 HOH   32  732 11  HOH   HOH B . 
J 5 HOH   33  733 152 HOH   HOH B . 
J 5 HOH   34  734 75  HOH   HOH B . 
J 5 HOH   35  735 12  HOH   HOH B . 
J 5 HOH   36  736 51  HOH   HOH B . 
J 5 HOH   37  737 10  HOH   HOH B . 
J 5 HOH   38  738 107 HOH   HOH B . 
J 5 HOH   39  739 49  HOH   HOH B . 
J 5 HOH   40  740 126 HOH   HOH B . 
J 5 HOH   41  741 5   HOH   HOH B . 
J 5 HOH   42  742 53  HOH   HOH B . 
J 5 HOH   43  743 212 HOH   HOH B . 
J 5 HOH   44  744 172 HOH   HOH B . 
J 5 HOH   45  745 179 HOH   HOH B . 
J 5 HOH   46  746 112 HOH   HOH B . 
J 5 HOH   47  747 57  HOH   HOH B . 
J 5 HOH   48  748 188 HOH   HOH B . 
J 5 HOH   49  749 13  HOH   HOH B . 
J 5 HOH   50  750 109 HOH   HOH B . 
J 5 HOH   51  751 202 HOH   HOH B . 
J 5 HOH   52  752 194 HOH   HOH B . 
J 5 HOH   53  753 84  HOH   HOH B . 
J 5 HOH   54  754 187 HOH   HOH B . 
J 5 HOH   55  755 153 HOH   HOH B . 
J 5 HOH   56  756 30  HOH   HOH B . 
J 5 HOH   57  757 183 HOH   HOH B . 
J 5 HOH   58  758 25  HOH   HOH B . 
J 5 HOH   59  759 195 HOH   HOH B . 
J 5 HOH   60  760 145 HOH   HOH B . 
J 5 HOH   61  761 175 HOH   HOH B . 
J 5 HOH   62  762 149 HOH   HOH B . 
J 5 HOH   63  763 85  HOH   HOH B . 
J 5 HOH   64  764 113 HOH   HOH B . 
J 5 HOH   65  765 208 HOH   HOH B . 
J 5 HOH   66  766 134 HOH   HOH B . 
J 5 HOH   67  767 150 HOH   HOH B . 
J 5 HOH   68  768 224 HOH   HOH B . 
J 5 HOH   69  769 58  HOH   HOH B . 
J 5 HOH   70  770 118 HOH   HOH B . 
J 5 HOH   71  771 9   HOH   HOH B . 
J 5 HOH   72  772 102 HOH   HOH B . 
J 5 HOH   73  773 21  HOH   HOH B . 
J 5 HOH   74  774 110 HOH   HOH B . 
J 5 HOH   75  775 141 HOH   HOH B . 
J 5 HOH   76  776 56  HOH   HOH B . 
J 5 HOH   77  777 70  HOH   HOH B . 
J 5 HOH   78  778 117 HOH   HOH B . 
J 5 HOH   79  779 244 HOH   HOH B . 
J 5 HOH   80  780 35  HOH   HOH B . 
J 5 HOH   81  781 167 HOH   HOH B . 
J 5 HOH   82  782 26  HOH   HOH B . 
J 5 HOH   83  783 76  HOH   HOH B . 
J 5 HOH   84  784 163 HOH   HOH B . 
J 5 HOH   85  785 128 HOH   HOH B . 
J 5 HOH   86  786 226 HOH   HOH B . 
J 5 HOH   87  787 165 HOH   HOH B . 
J 5 HOH   88  788 71  HOH   HOH B . 
J 5 HOH   89  789 115 HOH   HOH B . 
J 5 HOH   90  790 22  HOH   HOH B . 
J 5 HOH   91  791 232 HOH   HOH B . 
J 5 HOH   92  792 129 HOH   HOH B . 
J 5 HOH   93  793 182 HOH   HOH B . 
J 5 HOH   94  794 185 HOH   HOH B . 
J 5 HOH   95  795 220 HOH   HOH B . 
J 5 HOH   96  796 146 HOH   HOH B . 
J 5 HOH   97  797 219 HOH   HOH B . 
J 5 HOH   98  798 38  HOH   HOH B . 
J 5 HOH   99  799 89  HOH   HOH B . 
J 5 HOH   100 800 135 HOH   HOH B . 
J 5 HOH   101 801 231 HOH   HOH B . 
J 5 HOH   102 802 92  HOH   HOH B . 
J 5 HOH   103 803 41  HOH   HOH B . 
J 5 HOH   104 804 259 HOH   HOH B . 
J 5 HOH   105 805 161 HOH   HOH B . 
J 5 HOH   106 806 227 HOH   HOH B . 
J 5 HOH   107 807 261 HOH   HOH B . 
J 5 HOH   108 808 46  HOH   HOH B . 
J 5 HOH   109 809 156 HOH   HOH B . 
J 5 HOH   110 810 251 HOH   HOH B . 
J 5 HOH   111 811 225 HOH   HOH B . 
J 5 HOH   112 812 171 HOH   HOH B . 
J 5 HOH   113 813 236 HOH   HOH B . 
J 5 HOH   114 814 243 HOH   HOH B . 
J 5 HOH   115 815 160 HOH   HOH B . 
J 5 HOH   116 816 262 HOH   HOH B . 
J 5 HOH   117 817 229 HOH   HOH B . 
J 5 HOH   118 818 131 HOH   HOH B . 
J 5 HOH   119 819 257 HOH   HOH B . 
J 5 HOH   120 820 239 HOH   HOH B . 
J 5 HOH   121 821 216 HOH   HOH B . 
J 5 HOH   122 822 250 HOH   HOH B . 
J 5 HOH   123 823 159 HOH   HOH B . 
J 5 HOH   124 824 73  HOH   HOH B . 
J 5 HOH   125 825 211 HOH   HOH B . 
J 5 HOH   126 826 178 HOH   HOH B . 
J 5 HOH   127 827 265 HOH   HOH B . 
J 5 HOH   128 828 260 HOH   HOH B . 
J 5 HOH   129 829 83  HOH   HOH B . 
J 5 HOH   130 830 240 HOH   HOH B . 
J 5 HOH   131 831 253 HOH   HOH B . 
J 5 HOH   132 832 254 HOH   HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC      ? ? ? V8        1 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX      ? ? ? 1.10_2155 2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? CrysalisPro ? ? ? 171.39.46 3 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9LO7 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     57.348 
_cell.length_a_esd                 ? 
_cell.length_b                     79.685 
_cell.length_b_esd                 ? 
_cell.length_c                     162.299 
_cell.length_c_esd                 ? 
_cell.volume                       741671.473 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9LO7 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9LO7 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             1.61 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          23.37 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M HEPES (pH 7.4), 0.1 M MgCl2, 12-15% PEG3350, 10% isopropanol, and 25% ethylene glycol' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'RIGAKU HyPix-3000' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2025-01-06 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.5418 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        RIGAKU 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.5418 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          19.6477728771 
_reflns.entry_id                                       9LO7 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.2 
_reflns.d_resolution_low                               22.47 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     37773 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           97.94 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                4.3 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          13.9 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.149 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.2 
_reflns_shell.d_res_low                                     2.3 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           3.0 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3820 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               4.1 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          100 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.368 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               28.2406758648 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9LO7 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.20006247911 
_refine.ls_d_res_low                             22.4667408336 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     37773 
_refine.ls_number_reflns_R_free                  1908 
_refine.ls_number_reflns_R_work                  35865 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    97.9361663512 
_refine.ls_percent_reflns_R_free                 5.05122706695 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.227479941172 
_refine.ls_R_factor_R_free                       0.29344744532 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.224016135498 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34885013994 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               NONE 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      5WQA 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 28.0576889818 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.316254670457 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.20006247911 
_refine_hist.d_res_low                        22.4667408336 
_refine_hist.number_atoms_solvent             279 
_refine_hist.number_atoms_total               5571 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        5218 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         74 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.00815785568187 ? 5404 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.949472533998   ? 7349 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0487222635605  ? 837  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.00601377490258 ? 938  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 17.4613275378    ? 3281 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.2001 2.255  . . 172 2525 99.7780244173 . . . . 0.281996773624 . . . . . . . . . . . 0.341155494819 
'X-RAY DIFFRACTION' 2.255  2.3159 . . 148 2569 99.9264435454 . . . . 0.270198937025 . . . . . . . . . . . 0.339596792928 
'X-RAY DIFFRACTION' 2.3159 2.384  . . 124 2593 100.0         . . . . 0.245780529365 . . . . . . . . . . . 0.329006272857 
'X-RAY DIFFRACTION' 2.384  2.4609 . . 125 2594 99.9264976112 . . . . 0.247454020731 . . . . . . . . . . . 0.34681450032  
'X-RAY DIFFRACTION' 2.4609 2.5487 . . 143 2564 99.6319470004 . . . . 0.256594355084 . . . . . . . . . . . 0.337255261657 
'X-RAY DIFFRACTION' 2.5487 2.6506 . . 136 2595 99.817251462  . . . . 0.245100833265 . . . . . . . . . . . 0.317472701687 
'X-RAY DIFFRACTION' 2.6506 2.771  . . 139 2549 99.7772828508 . . . . 0.242884408184 . . . . . . . . . . . 0.311451385059 
'X-RAY DIFFRACTION' 2.771  2.9168 . . 155 2593 99.4931209269 . . . . 0.247884388676 . . . . . . . . . . . 0.329586202889 
'X-RAY DIFFRACTION' 2.9168 3.0992 . . 143 2561 98.9751098097 . . . . 0.244241717065 . . . . . . . . . . . 0.366967660537 
'X-RAY DIFFRACTION' 3.0992 3.3377 . . 117 2558 97.3435225619 . . . . 0.229079149737 . . . . . . . . . . . 0.298534974591 
'X-RAY DIFFRACTION' 3.3377 3.6723 . . 120 2545 96.2789017341 . . . . 0.21178773832  . . . . . . . . . . . 0.299315524514 
'X-RAY DIFFRACTION' 3.6723 4.2007 . . 142 2519 95.2738990333 . . . . 0.192006519986 . . . . . . . . . . . 0.241167565382 
'X-RAY DIFFRACTION' 4.2007 5.2811 . . 126 2520 94.2643391521 . . . . 0.180558598417 . . . . . . . . . . . 0.209018761063 
'X-RAY DIFFRACTION' 5.2811 22.466 . . 118 2580 91.5196743555 . . . . 0.196779668137 . . . . . . . . . . . 0.243447954504 
# 
_struct.entry_id                     9LO7 
_struct.title                        'The crystal structure of PDE4D with 2317b' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9LO7 
_struct_keywords.text            'Inhibitor, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 2 ? 
G N N 3 ? 
H N N 4 ? 
I N N 5 ? 
J N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    PDE4D_HUMAN 
_struct_ref.pdbx_db_accession          Q08499 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIP
RFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYH
NNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKL
LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLS
NPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLE
DNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDE
QVEEEAVGEEEESQPEACVIDDRSPD
;
_struct_ref.pdbx_align_begin           303 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9LO7 A 1 ? 506 ? Q08499 303 ? 808 ? 1 506 
2 1 9LO7 B 1 ? 506 ? Q08499 303 ? 808 ? 1 506 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_defined_assembly ? monomeric 1 
2 author_defined_assembly ? monomeric 1 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,C,D,E,I 
2 1 B,F,G,H,J 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLN A 88  ? LEU A 96  ? GLN A 88  LEU A 96  1 ? 9  
HELX_P HELX_P2  AA2 GLU A 97  ? VAL A 99  ? GLU A 97  VAL A 99  5 ? 3  
HELX_P HELX_P3  AA3 HIS A 105 ? SER A 113 ? HIS A 105 SER A 113 1 ? 9  
HELX_P HELX_P4  AA4 ARG A 116 ? ARG A 129 ? ARG A 116 ARG A 129 1 ? 14 
HELX_P HELX_P5  AA5 ASP A 130 ? PHE A 135 ? ASP A 130 PHE A 135 1 ? 6  
HELX_P HELX_P6  AA6 PRO A 138 ? HIS A 152 ? PRO A 138 HIS A 152 1 ? 15 
HELX_P HELX_P7  AA7 ASN A 161 ? SER A 177 ? ASN A 161 SER A 177 1 ? 17 
HELX_P HELX_P8  AA8 THR A 178 ? GLU A 182 ? THR A 178 GLU A 182 5 ? 5  
HELX_P HELX_P9  AA9 THR A 186 ? HIS A 200 ? THR A 186 HIS A 200 1 ? 15 
HELX_P HELX_P10 AB1 SER A 208 ? THR A 215 ? SER A 208 THR A 215 1 ? 8  
HELX_P HELX_P11 AB2 SER A 217 ? ASN A 224 ? SER A 217 ASN A 224 1 ? 8  
HELX_P HELX_P12 AB3 SER A 227 ? LEU A 240 ? SER A 227 LEU A 240 1 ? 14 
HELX_P HELX_P13 AB4 LEU A 241 ? GLU A 243 ? LEU A 241 GLU A 243 5 ? 3  
HELX_P HELX_P14 AB5 THR A 253 ? ALA A 270 ? THR A 253 ALA A 270 1 ? 18 
HELX_P HELX_P15 AB6 THR A 271 ? SER A 274 ? THR A 271 SER A 274 5 ? 4  
HELX_P HELX_P16 AB7 LYS A 275 ? THR A 289 ? LYS A 275 THR A 289 1 ? 15 
HELX_P HELX_P17 AB8 ASN A 302 ? LEU A 319 ? ASN A 302 LEU A 319 1 ? 18 
HELX_P HELX_P18 AB9 SER A 320 ? LYS A 324 ? SER A 320 LYS A 324 5 ? 5  
HELX_P HELX_P19 AC1 PRO A 325 ? GLU A 349 ? PRO A 325 GLU A 349 1 ? 25 
HELX_P HELX_P20 AC2 SER A 364 ? ILE A 376 ? SER A 364 ILE A 376 1 ? 13 
HELX_P HELX_P21 AC3 ILE A 376 ? VAL A 388 ? ILE A 376 VAL A 388 1 ? 13 
HELX_P HELX_P22 AC4 ALA A 392 ? THR A 409 ? ALA A 392 THR A 409 1 ? 18 
HELX_P HELX_P23 AC5 LEU B 92  ? GLU B 97  ? LEU B 92  GLU B 97  1 ? 6  
HELX_P HELX_P24 AC6 HIS B 105 ? SER B 113 ? HIS B 105 SER B 113 1 ? 9  
HELX_P HELX_P25 AC7 ARG B 116 ? ASP B 130 ? ARG B 116 ASP B 130 1 ? 15 
HELX_P HELX_P26 AC8 ASP B 130 ? PHE B 135 ? ASP B 130 PHE B 135 1 ? 6  
HELX_P HELX_P27 AC9 PRO B 138 ? HIS B 152 ? PRO B 138 HIS B 152 1 ? 15 
HELX_P HELX_P28 AD1 ASN B 161 ? SER B 177 ? ASN B 161 SER B 177 1 ? 17 
HELX_P HELX_P29 AD2 THR B 178 ? GLU B 182 ? THR B 178 GLU B 182 5 ? 5  
HELX_P HELX_P30 AD3 THR B 186 ? HIS B 200 ? THR B 186 HIS B 200 1 ? 15 
HELX_P HELX_P31 AD4 SER B 208 ? THR B 215 ? SER B 208 THR B 215 1 ? 8  
HELX_P HELX_P32 AD5 SER B 217 ? ASN B 224 ? SER B 217 ASN B 224 1 ? 8  
HELX_P HELX_P33 AD6 SER B 227 ? LEU B 240 ? SER B 227 LEU B 240 1 ? 14 
HELX_P HELX_P34 AD7 LEU B 241 ? GLU B 243 ? LEU B 241 GLU B 243 5 ? 3  
HELX_P HELX_P35 AD8 THR B 253 ? ALA B 270 ? THR B 253 ALA B 270 1 ? 18 
HELX_P HELX_P36 AD9 THR B 271 ? SER B 274 ? THR B 271 SER B 274 5 ? 4  
HELX_P HELX_P37 AE1 LYS B 275 ? THR B 289 ? LYS B 275 THR B 289 1 ? 15 
HELX_P HELX_P38 AE2 ASN B 302 ? LEU B 319 ? ASN B 302 LEU B 319 1 ? 18 
HELX_P HELX_P39 AE3 SER B 320 ? LYS B 324 ? SER B 320 LYS B 324 5 ? 5  
HELX_P HELX_P40 AE4 PRO B 325 ? ARG B 350 ? PRO B 325 ARG B 350 1 ? 26 
HELX_P HELX_P41 AE5 ASP B 359 ? ALA B 363 ? ASP B 359 ALA B 363 5 ? 5  
HELX_P HELX_P42 AE6 SER B 364 ? ILE B 376 ? SER B 364 ILE B 376 1 ? 13 
HELX_P HELX_P43 AE7 ILE B 376 ? HIS B 389 ? ILE B 376 HIS B 389 1 ? 14 
HELX_P HELX_P44 AE8 ALA B 392 ? THR B 409 ? ALA B 392 THR B 409 1 ? 18 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A HIS 164 NE2 ? ? ? 1_555 C ZN  . ZN ? ? A HIS 164 A ZN  601 1_555 ? ? ? ? ? ? ? 2.158 ? ? 
metalc2  metalc ? ? A HIS 200 NE2 ? ? ? 1_555 C ZN  . ZN ? ? A HIS 200 A ZN  601 1_555 ? ? ? ? ? ? ? 2.182 ? ? 
metalc3  metalc ? ? A ASP 201 OD2 ? ? ? 1_555 C ZN  . ZN ? ? A ASP 201 A ZN  601 1_555 ? ? ? ? ? ? ? 2.051 ? ? 
metalc4  metalc ? ? A ASP 201 OD1 ? ? ? 1_555 D MG  . MG ? ? A ASP 201 A MG  602 1_555 ? ? ? ? ? ? ? 2.025 ? ? 
metalc5  metalc ? ? A ASP 318 OD1 ? ? ? 1_555 C ZN  . ZN ? ? A ASP 318 A ZN  601 1_555 ? ? ? ? ? ? ? 2.066 ? ? 
metalc6  metalc ? ? C ZN  .   ZN  ? ? ? 1_555 I HOH . O  ? ? A ZN  601 A HOH 702 1_555 ? ? ? ? ? ? ? 2.178 ? ? 
metalc7  metalc ? ? C ZN  .   ZN  ? ? ? 1_555 I HOH . O  ? ? A ZN  601 A HOH 752 1_555 ? ? ? ? ? ? ? 2.129 ? ? 
metalc8  metalc ? ? D MG  .   MG  ? ? ? 1_555 I HOH . O  ? ? A MG  602 A HOH 702 1_555 ? ? ? ? ? ? ? 2.033 ? ? 
metalc9  metalc ? ? D MG  .   MG  ? ? ? 1_555 I HOH . O  ? ? A MG  602 A HOH 712 1_555 ? ? ? ? ? ? ? 2.248 ? ? 
metalc10 metalc ? ? D MG  .   MG  ? ? ? 1_555 I HOH . O  ? ? A MG  602 A HOH 724 1_555 ? ? ? ? ? ? ? 1.982 ? ? 
metalc11 metalc ? ? D MG  .   MG  ? ? ? 1_555 I HOH . O  ? ? A MG  602 A HOH 740 1_555 ? ? ? ? ? ? ? 2.180 ? ? 
metalc12 metalc ? ? D MG  .   MG  ? ? ? 1_555 I HOH . O  ? ? A MG  602 A HOH 788 1_555 ? ? ? ? ? ? ? 2.037 ? ? 
metalc13 metalc ? ? B HIS 164 NE2 ? ? ? 1_555 F ZN  . ZN ? ? B HIS 164 B ZN  601 1_555 ? ? ? ? ? ? ? 2.172 ? ? 
metalc14 metalc ? ? B HIS 200 NE2 ? ? ? 1_555 F ZN  . ZN ? ? B HIS 200 B ZN  601 1_555 ? ? ? ? ? ? ? 2.227 ? ? 
metalc15 metalc ? ? B ASP 201 OD2 ? ? ? 1_555 F ZN  . ZN ? ? B ASP 201 B ZN  601 1_555 ? ? ? ? ? ? ? 2.056 ? ? 
metalc16 metalc ? ? B ASP 201 OD1 ? ? ? 1_555 G MG  . MG ? ? B ASP 201 B MG  602 1_555 ? ? ? ? ? ? ? 2.051 ? ? 
metalc17 metalc ? ? B ASP 318 OD1 ? ? ? 1_555 F ZN  . ZN ? ? B ASP 318 B ZN  601 1_555 ? ? ? ? ? ? ? 2.074 ? ? 
metalc18 metalc ? ? F ZN  .   ZN  ? ? ? 1_555 J HOH . O  ? ? B ZN  601 B HOH 715 1_555 ? ? ? ? ? ? ? 2.105 ? ? 
metalc19 metalc ? ? F ZN  .   ZN  ? ? ? 1_555 J HOH . O  ? ? B ZN  601 B HOH 723 1_555 ? ? ? ? ? ? ? 2.338 ? ? 
metalc20 metalc ? ? G MG  .   MG  ? ? ? 1_555 J HOH . O  ? ? B MG  602 B HOH 705 1_555 ? ? ? ? ? ? ? 2.195 ? ? 
metalc21 metalc ? ? G MG  .   MG  ? ? ? 1_555 J HOH . O  ? ? B MG  602 B HOH 715 1_555 ? ? ? ? ? ? ? 2.033 ? ? 
metalc22 metalc ? ? G MG  .   MG  ? ? ? 1_555 J HOH . O  ? ? B MG  602 B HOH 732 1_555 ? ? ? ? ? ? ? 2.221 ? ? 
metalc23 metalc ? ? G MG  .   MG  ? ? ? 1_555 J HOH . O  ? ? B MG  602 B HOH 735 1_555 ? ? ? ? ? ? ? 2.170 ? ? 
metalc24 metalc ? ? G MG  .   MG  ? ? ? 1_555 J HOH . O  ? ? B MG  602 B HOH 771 1_555 ? ? ? ? ? ? ? 2.004 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  NE2 ? A HIS 164 ? A HIS 164 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 NE2 ? A HIS 200 ? A HIS 200 ? 1_555 97.1  ? 
2  NE2 ? A HIS 164 ? A HIS 164 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 OD2 ? A ASP 201 ? A ASP 201 ? 1_555 92.7  ? 
3  NE2 ? A HIS 200 ? A HIS 200 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 OD2 ? A ASP 201 ? A ASP 201 ? 1_555 83.8  ? 
4  NE2 ? A HIS 164 ? A HIS 164 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 OD1 ? A ASP 318 ? A ASP 318 ? 1_555 84.0  ? 
5  NE2 ? A HIS 200 ? A HIS 200 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 OD1 ? A ASP 318 ? A ASP 318 ? 1_555 90.5  ? 
6  OD2 ? A ASP 201 ? A ASP 201 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 OD1 ? A ASP 318 ? A ASP 318 ? 1_555 173.0 ? 
7  NE2 ? A HIS 164 ? A HIS 164 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 702 ? 1_555 173.4 ? 
8  NE2 ? A HIS 200 ? A HIS 200 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 702 ? 1_555 88.5  ? 
9  OD2 ? A ASP 201 ? A ASP 201 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 702 ? 1_555 84.5  ? 
10 OD1 ? A ASP 318 ? A ASP 318 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 702 ? 1_555 99.5  ? 
11 NE2 ? A HIS 164 ? A HIS 164 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 752 ? 1_555 88.8  ? 
12 NE2 ? A HIS 200 ? A HIS 200 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 752 ? 1_555 173.7 ? 
13 OD2 ? A ASP 201 ? A ASP 201 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 752 ? 1_555 93.9  ? 
14 OD1 ? A ASP 318 ? A ASP 318 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 752 ? 1_555 92.1  ? 
15 O   ? I HOH .   ? A HOH 702 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 752 ? 1_555 85.4  ? 
16 OD1 ? A ASP 201 ? A ASP 201 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 702 ? 1_555 97.3  ? 
17 OD1 ? A ASP 201 ? A ASP 201 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 712 ? 1_555 162.2 ? 
18 O   ? I HOH .   ? A HOH 702 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 712 ? 1_555 97.7  ? 
19 OD1 ? A ASP 201 ? A ASP 201 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 724 ? 1_555 82.6  ? 
20 O   ? I HOH .   ? A HOH 702 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 724 ? 1_555 94.1  ? 
21 O   ? I HOH .   ? A HOH 712 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 724 ? 1_555 86.9  ? 
22 OD1 ? A ASP 201 ? A ASP 201 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 740 ? 1_555 87.4  ? 
23 O   ? I HOH .   ? A HOH 702 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 740 ? 1_555 174.6 ? 
24 O   ? I HOH .   ? A HOH 712 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 740 ? 1_555 78.1  ? 
25 O   ? I HOH .   ? A HOH 724 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 740 ? 1_555 89.1  ? 
26 OD1 ? A ASP 201 ? A ASP 201 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 788 ? 1_555 96.4  ? 
27 O   ? I HOH .   ? A HOH 702 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 788 ? 1_555 90.3  ? 
28 O   ? I HOH .   ? A HOH 712 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 788 ? 1_555 93.0  ? 
29 O   ? I HOH .   ? A HOH 724 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 788 ? 1_555 175.6 ? 
30 O   ? I HOH .   ? A HOH 740 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 788 ? 1_555 86.6  ? 
31 NE2 ? B HIS 164 ? B HIS 164 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 NE2 ? B HIS 200 ? B HIS 200 ? 1_555 91.7  ? 
32 NE2 ? B HIS 164 ? B HIS 164 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 OD2 ? B ASP 201 ? B ASP 201 ? 1_555 89.9  ? 
33 NE2 ? B HIS 200 ? B HIS 200 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 OD2 ? B ASP 201 ? B ASP 201 ? 1_555 82.4  ? 
34 NE2 ? B HIS 164 ? B HIS 164 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 OD1 ? B ASP 318 ? B ASP 318 ? 1_555 91.1  ? 
35 NE2 ? B HIS 200 ? B HIS 200 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 OD1 ? B ASP 318 ? B ASP 318 ? 1_555 87.6  ? 
36 OD2 ? B ASP 201 ? B ASP 201 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 OD1 ? B ASP 318 ? B ASP 318 ? 1_555 170.0 ? 
37 NE2 ? B HIS 164 ? B HIS 164 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 715 ? 1_555 175.3 ? 
38 NE2 ? B HIS 200 ? B HIS 200 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 715 ? 1_555 93.0  ? 
39 OD2 ? B ASP 201 ? B ASP 201 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 715 ? 1_555 90.4  ? 
40 OD1 ? B ASP 318 ? B ASP 318 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 715 ? 1_555 89.4  ? 
41 NE2 ? B HIS 164 ? B HIS 164 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 723 ? 1_555 86.8  ? 
42 NE2 ? B HIS 200 ? B HIS 200 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 723 ? 1_555 173.2 ? 
43 OD2 ? B ASP 201 ? B ASP 201 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 723 ? 1_555 104.3 ? 
44 OD1 ? B ASP 318 ? B ASP 318 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 723 ? 1_555 85.8  ? 
45 O   ? J HOH .   ? B HOH 715 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 723 ? 1_555 88.6  ? 
46 OD1 ? B ASP 201 ? B ASP 201 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 705 ? 1_555 83.4  ? 
47 OD1 ? B ASP 201 ? B ASP 201 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 715 ? 1_555 104.9 ? 
48 O   ? J HOH .   ? B HOH 705 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 715 ? 1_555 92.9  ? 
49 OD1 ? B ASP 201 ? B ASP 201 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 732 ? 1_555 86.4  ? 
50 O   ? J HOH .   ? B HOH 705 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 732 ? 1_555 87.5  ? 
51 O   ? J HOH .   ? B HOH 715 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 732 ? 1_555 168.6 ? 
52 OD1 ? B ASP 201 ? B ASP 201 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 735 ? 1_555 162.8 ? 
53 O   ? J HOH .   ? B HOH 705 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 735 ? 1_555 86.6  ? 
54 O   ? J HOH .   ? B HOH 715 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 735 ? 1_555 89.5  ? 
55 O   ? J HOH .   ? B HOH 732 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 735 ? 1_555 79.2  ? 
56 OD1 ? B ASP 201 ? B ASP 201 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 771 ? 1_555 102.2 ? 
57 O   ? J HOH .   ? B HOH 705 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 771 ? 1_555 167.8 ? 
58 O   ? J HOH .   ? B HOH 715 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 771 ? 1_555 96.1  ? 
59 O   ? J HOH .   ? B HOH 732 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 771 ? 1_555 82.1  ? 
60 O   ? J HOH .   ? B HOH 735 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 771 ? 1_555 85.3  ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 HIS 389 A . ? HIS 389 A PRO 390 A ? PRO 390 A 1 0.96  
2 HIS 389 B . ? HIS 389 B PRO 390 B ? PRO 390 B 1 -0.52 
# 
_pdbx_entry_details.entry_id                   9LO7 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   SG 
_pdbx_validate_close_contact.auth_asym_id_1   B 
_pdbx_validate_close_contact.auth_comp_id_1   CYS 
_pdbx_validate_close_contact.auth_seq_id_1    316 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O 
_pdbx_validate_close_contact.auth_asym_id_2   B 
_pdbx_validate_close_contact.auth_comp_id_2   HOH 
_pdbx_validate_close_contact.auth_seq_id_2    774 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.04 
# 
loop_
_pdbx_validate_symm_contact.id 
_pdbx_validate_symm_contact.PDB_model_num 
_pdbx_validate_symm_contact.auth_atom_id_1 
_pdbx_validate_symm_contact.auth_asym_id_1 
_pdbx_validate_symm_contact.auth_comp_id_1 
_pdbx_validate_symm_contact.auth_seq_id_1 
_pdbx_validate_symm_contact.PDB_ins_code_1 
_pdbx_validate_symm_contact.label_alt_id_1 
_pdbx_validate_symm_contact.site_symmetry_1 
_pdbx_validate_symm_contact.auth_atom_id_2 
_pdbx_validate_symm_contact.auth_asym_id_2 
_pdbx_validate_symm_contact.auth_comp_id_2 
_pdbx_validate_symm_contact.auth_seq_id_2 
_pdbx_validate_symm_contact.PDB_ins_code_2 
_pdbx_validate_symm_contact.label_alt_id_2 
_pdbx_validate_symm_contact.site_symmetry_2 
_pdbx_validate_symm_contact.dist 
1 1 NH2 A ARG 330 ? ? 1_555 O B SER 408 ? ? 2_455 1.67 
2 1 NH2 A ARG 330 ? ? 1_555 C B SER 408 ? ? 2_455 2.17 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             C 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             ILE 
_pdbx_validate_rmsd_angle.auth_seq_id_1              410 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             N 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             PRO 
_pdbx_validate_rmsd_angle.auth_seq_id_2              411 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             CA 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             PRO 
_pdbx_validate_rmsd_angle.auth_seq_id_3              411 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                128.62 
_pdbx_validate_rmsd_angle.angle_target_value         119.30 
_pdbx_validate_rmsd_angle.angle_deviation            9.32 
_pdbx_validate_rmsd_angle.angle_standard_deviation   1.50 
_pdbx_validate_rmsd_angle.linker_flag                Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 LEU A 104 ? ? -30.41  134.00  
2  1 TYR A 159 ? ? -105.91 -60.95  
3  1 ASN A 161 ? ? -117.70 -166.40 
4  1 ALA A 183 ? ? 57.54   15.10   
5  1 GLU A 349 ? ? -64.21  11.38   
6  1 ASN A 362 ? ? -146.91 42.99   
7  1 GLU B 97  ? ? -60.70  2.51    
8  1 ARG B 116 ? ? -143.90 51.91   
9  1 SER B 177 ? ? -86.64  38.52   
10 1 LEU B 181 ? ? -119.91 60.21   
11 1 ALA B 183 ? ? 39.70   48.59   
12 1 ASP B 201 ? ? -140.19 24.18   
13 1 THR B 289 ? ? -102.02 48.36   
14 1 SER B 295 ? ? -63.81  -89.06  
15 1 ASP B 301 ? ? -109.40 -62.29  
16 1 LEU B 319 ? ? -105.76 40.92   
17 1 ASN B 362 ? ? -144.48 50.83   
18 1 ILE B 376 ? ? -127.45 -59.08  
19 1 HIS B 389 ? ? -32.91  116.97  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 847 ? 6.43 . 
2 1 O ? B HOH 832 ? 7.06 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET 1   ? A MET 1   
2   1 Y 1 A ALA 2   ? A ALA 2   
3   1 Y 1 A SER 3   ? A SER 3   
4   1 Y 1 A ASN 4   ? A ASN 4   
5   1 Y 1 A LYS 5   ? A LYS 5   
6   1 Y 1 A PHE 6   ? A PHE 6   
7   1 Y 1 A LYS 7   ? A LYS 7   
8   1 Y 1 A ARG 8   ? A ARG 8   
9   1 Y 1 A MET 9   ? A MET 9   
10  1 Y 1 A LEU 10  ? A LEU 10  
11  1 Y 1 A ASN 11  ? A ASN 11  
12  1 Y 1 A ARG 12  ? A ARG 12  
13  1 Y 1 A GLU 13  ? A GLU 13  
14  1 Y 1 A LEU 14  ? A LEU 14  
15  1 Y 1 A THR 15  ? A THR 15  
16  1 Y 1 A HIS 16  ? A HIS 16  
17  1 Y 1 A LEU 17  ? A LEU 17  
18  1 Y 1 A SER 18  ? A SER 18  
19  1 Y 1 A GLU 19  ? A GLU 19  
20  1 Y 1 A MET 20  ? A MET 20  
21  1 Y 1 A SER 21  ? A SER 21  
22  1 Y 1 A ARG 22  ? A ARG 22  
23  1 Y 1 A SER 23  ? A SER 23  
24  1 Y 1 A GLY 24  ? A GLY 24  
25  1 Y 1 A ASN 25  ? A ASN 25  
26  1 Y 1 A GLN 26  ? A GLN 26  
27  1 Y 1 A VAL 27  ? A VAL 27  
28  1 Y 1 A SER 28  ? A SER 28  
29  1 Y 1 A GLU 29  ? A GLU 29  
30  1 Y 1 A PHE 30  ? A PHE 30  
31  1 Y 1 A ILE 31  ? A ILE 31  
32  1 Y 1 A SER 32  ? A SER 32  
33  1 Y 1 A ASN 33  ? A ASN 33  
34  1 Y 1 A THR 34  ? A THR 34  
35  1 Y 1 A PHE 35  ? A PHE 35  
36  1 Y 1 A LEU 36  ? A LEU 36  
37  1 Y 1 A ASP 37  ? A ASP 37  
38  1 Y 1 A LYS 38  ? A LYS 38  
39  1 Y 1 A GLN 39  ? A GLN 39  
40  1 Y 1 A HIS 40  ? A HIS 40  
41  1 Y 1 A GLU 41  ? A GLU 41  
42  1 Y 1 A VAL 42  ? A VAL 42  
43  1 Y 1 A GLU 43  ? A GLU 43  
44  1 Y 1 A ILE 44  ? A ILE 44  
45  1 Y 1 A PRO 45  ? A PRO 45  
46  1 Y 1 A SER 46  ? A SER 46  
47  1 Y 1 A PRO 47  ? A PRO 47  
48  1 Y 1 A THR 48  ? A THR 48  
49  1 Y 1 A GLN 49  ? A GLN 49  
50  1 Y 1 A LYS 50  ? A LYS 50  
51  1 Y 1 A GLU 51  ? A GLU 51  
52  1 Y 1 A LYS 52  ? A LYS 52  
53  1 Y 1 A GLU 53  ? A GLU 53  
54  1 Y 1 A LYS 54  ? A LYS 54  
55  1 Y 1 A LYS 55  ? A LYS 55  
56  1 Y 1 A LYS 56  ? A LYS 56  
57  1 Y 1 A ARG 57  ? A ARG 57  
58  1 Y 1 A PRO 58  ? A PRO 58  
59  1 Y 1 A MET 59  ? A MET 59  
60  1 Y 1 A SER 60  ? A SER 60  
61  1 Y 1 A GLN 61  ? A GLN 61  
62  1 Y 1 A ILE 62  ? A ILE 62  
63  1 Y 1 A SER 63  ? A SER 63  
64  1 Y 1 A GLY 64  ? A GLY 64  
65  1 Y 1 A VAL 65  ? A VAL 65  
66  1 Y 1 A LYS 66  ? A LYS 66  
67  1 Y 1 A LYS 67  ? A LYS 67  
68  1 Y 1 A LEU 68  ? A LEU 68  
69  1 Y 1 A MET 69  ? A MET 69  
70  1 Y 1 A HIS 70  ? A HIS 70  
71  1 Y 1 A SER 71  ? A SER 71  
72  1 Y 1 A SER 72  ? A SER 72  
73  1 Y 1 A SER 73  ? A SER 73  
74  1 Y 1 A LEU 74  ? A LEU 74  
75  1 Y 1 A THR 75  ? A THR 75  
76  1 Y 1 A ASN 76  ? A ASN 76  
77  1 Y 1 A SER 77  ? A SER 77  
78  1 Y 1 A SER 78  ? A SER 78  
79  1 Y 1 A ILE 79  ? A ILE 79  
80  1 Y 1 A PRO 80  ? A PRO 80  
81  1 Y 1 A ARG 81  ? A ARG 81  
82  1 Y 1 A PHE 82  ? A PHE 82  
83  1 Y 1 A GLY 83  ? A GLY 83  
84  1 Y 1 A VAL 84  ? A VAL 84  
85  1 Y 1 A LYS 85  ? A LYS 85  
86  1 Y 1 A THR 86  ? A THR 86  
87  1 Y 1 A GLU 87  ? A GLU 87  
88  1 Y 1 A GLN 412 ? A GLN 412 
89  1 Y 1 A SER 413 ? A SER 413 
90  1 Y 1 A PRO 414 ? A PRO 414 
91  1 Y 1 A SER 415 ? A SER 415 
92  1 Y 1 A PRO 416 ? A PRO 416 
93  1 Y 1 A ALA 417 ? A ALA 417 
94  1 Y 1 A PRO 418 ? A PRO 418 
95  1 Y 1 A ASP 419 ? A ASP 419 
96  1 Y 1 A ASP 420 ? A ASP 420 
97  1 Y 1 A PRO 421 ? A PRO 421 
98  1 Y 1 A GLU 422 ? A GLU 422 
99  1 Y 1 A GLU 423 ? A GLU 423 
100 1 Y 1 A GLY 424 ? A GLY 424 
101 1 Y 1 A ARG 425 ? A ARG 425 
102 1 Y 1 A GLN 426 ? A GLN 426 
103 1 Y 1 A GLY 427 ? A GLY 427 
104 1 Y 1 A GLN 428 ? A GLN 428 
105 1 Y 1 A THR 429 ? A THR 429 
106 1 Y 1 A GLU 430 ? A GLU 430 
107 1 Y 1 A LYS 431 ? A LYS 431 
108 1 Y 1 A PHE 432 ? A PHE 432 
109 1 Y 1 A GLN 433 ? A GLN 433 
110 1 Y 1 A PHE 434 ? A PHE 434 
111 1 Y 1 A GLU 435 ? A GLU 435 
112 1 Y 1 A LEU 436 ? A LEU 436 
113 1 Y 1 A THR 437 ? A THR 437 
114 1 Y 1 A LEU 438 ? A LEU 438 
115 1 Y 1 A GLU 439 ? A GLU 439 
116 1 Y 1 A GLU 440 ? A GLU 440 
117 1 Y 1 A ASP 441 ? A ASP 441 
118 1 Y 1 A GLY 442 ? A GLY 442 
119 1 Y 1 A GLU 443 ? A GLU 443 
120 1 Y 1 A SER 444 ? A SER 444 
121 1 Y 1 A ASP 445 ? A ASP 445 
122 1 Y 1 A THR 446 ? A THR 446 
123 1 Y 1 A GLU 447 ? A GLU 447 
124 1 Y 1 A LYS 448 ? A LYS 448 
125 1 Y 1 A ASP 449 ? A ASP 449 
126 1 Y 1 A SER 450 ? A SER 450 
127 1 Y 1 A GLY 451 ? A GLY 451 
128 1 Y 1 A SER 452 ? A SER 452 
129 1 Y 1 A GLN 453 ? A GLN 453 
130 1 Y 1 A VAL 454 ? A VAL 454 
131 1 Y 1 A GLU 455 ? A GLU 455 
132 1 Y 1 A GLU 456 ? A GLU 456 
133 1 Y 1 A ASP 457 ? A ASP 457 
134 1 Y 1 A THR 458 ? A THR 458 
135 1 Y 1 A SER 459 ? A SER 459 
136 1 Y 1 A CYS 460 ? A CYS 460 
137 1 Y 1 A SER 461 ? A SER 461 
138 1 Y 1 A ASP 462 ? A ASP 462 
139 1 Y 1 A SER 463 ? A SER 463 
140 1 Y 1 A LYS 464 ? A LYS 464 
141 1 Y 1 A THR 465 ? A THR 465 
142 1 Y 1 A LEU 466 ? A LEU 466 
143 1 Y 1 A CYS 467 ? A CYS 467 
144 1 Y 1 A THR 468 ? A THR 468 
145 1 Y 1 A GLN 469 ? A GLN 469 
146 1 Y 1 A ASP 470 ? A ASP 470 
147 1 Y 1 A SER 471 ? A SER 471 
148 1 Y 1 A GLU 472 ? A GLU 472 
149 1 Y 1 A SER 473 ? A SER 473 
150 1 Y 1 A THR 474 ? A THR 474 
151 1 Y 1 A GLU 475 ? A GLU 475 
152 1 Y 1 A ILE 476 ? A ILE 476 
153 1 Y 1 A PRO 477 ? A PRO 477 
154 1 Y 1 A LEU 478 ? A LEU 478 
155 1 Y 1 A ASP 479 ? A ASP 479 
156 1 Y 1 A GLU 480 ? A GLU 480 
157 1 Y 1 A GLN 481 ? A GLN 481 
158 1 Y 1 A VAL 482 ? A VAL 482 
159 1 Y 1 A GLU 483 ? A GLU 483 
160 1 Y 1 A GLU 484 ? A GLU 484 
161 1 Y 1 A GLU 485 ? A GLU 485 
162 1 Y 1 A ALA 486 ? A ALA 486 
163 1 Y 1 A VAL 487 ? A VAL 487 
164 1 Y 1 A GLY 488 ? A GLY 488 
165 1 Y 1 A GLU 489 ? A GLU 489 
166 1 Y 1 A GLU 490 ? A GLU 490 
167 1 Y 1 A GLU 491 ? A GLU 491 
168 1 Y 1 A GLU 492 ? A GLU 492 
169 1 Y 1 A SER 493 ? A SER 493 
170 1 Y 1 A GLN 494 ? A GLN 494 
171 1 Y 1 A PRO 495 ? A PRO 495 
172 1 Y 1 A GLU 496 ? A GLU 496 
173 1 Y 1 A ALA 497 ? A ALA 497 
174 1 Y 1 A CYS 498 ? A CYS 498 
175 1 Y 1 A VAL 499 ? A VAL 499 
176 1 Y 1 A ILE 500 ? A ILE 500 
177 1 Y 1 A ASP 501 ? A ASP 501 
178 1 Y 1 A ASP 502 ? A ASP 502 
179 1 Y 1 A ARG 503 ? A ARG 503 
180 1 Y 1 A SER 504 ? A SER 504 
181 1 Y 1 A PRO 505 ? A PRO 505 
182 1 Y 1 A ASP 506 ? A ASP 506 
183 1 Y 1 B MET 1   ? B MET 1   
184 1 Y 1 B ALA 2   ? B ALA 2   
185 1 Y 1 B SER 3   ? B SER 3   
186 1 Y 1 B ASN 4   ? B ASN 4   
187 1 Y 1 B LYS 5   ? B LYS 5   
188 1 Y 1 B PHE 6   ? B PHE 6   
189 1 Y 1 B LYS 7   ? B LYS 7   
190 1 Y 1 B ARG 8   ? B ARG 8   
191 1 Y 1 B MET 9   ? B MET 9   
192 1 Y 1 B LEU 10  ? B LEU 10  
193 1 Y 1 B ASN 11  ? B ASN 11  
194 1 Y 1 B ARG 12  ? B ARG 12  
195 1 Y 1 B GLU 13  ? B GLU 13  
196 1 Y 1 B LEU 14  ? B LEU 14  
197 1 Y 1 B THR 15  ? B THR 15  
198 1 Y 1 B HIS 16  ? B HIS 16  
199 1 Y 1 B LEU 17  ? B LEU 17  
200 1 Y 1 B SER 18  ? B SER 18  
201 1 Y 1 B GLU 19  ? B GLU 19  
202 1 Y 1 B MET 20  ? B MET 20  
203 1 Y 1 B SER 21  ? B SER 21  
204 1 Y 1 B ARG 22  ? B ARG 22  
205 1 Y 1 B SER 23  ? B SER 23  
206 1 Y 1 B GLY 24  ? B GLY 24  
207 1 Y 1 B ASN 25  ? B ASN 25  
208 1 Y 1 B GLN 26  ? B GLN 26  
209 1 Y 1 B VAL 27  ? B VAL 27  
210 1 Y 1 B SER 28  ? B SER 28  
211 1 Y 1 B GLU 29  ? B GLU 29  
212 1 Y 1 B PHE 30  ? B PHE 30  
213 1 Y 1 B ILE 31  ? B ILE 31  
214 1 Y 1 B SER 32  ? B SER 32  
215 1 Y 1 B ASN 33  ? B ASN 33  
216 1 Y 1 B THR 34  ? B THR 34  
217 1 Y 1 B PHE 35  ? B PHE 35  
218 1 Y 1 B LEU 36  ? B LEU 36  
219 1 Y 1 B ASP 37  ? B ASP 37  
220 1 Y 1 B LYS 38  ? B LYS 38  
221 1 Y 1 B GLN 39  ? B GLN 39  
222 1 Y 1 B HIS 40  ? B HIS 40  
223 1 Y 1 B GLU 41  ? B GLU 41  
224 1 Y 1 B VAL 42  ? B VAL 42  
225 1 Y 1 B GLU 43  ? B GLU 43  
226 1 Y 1 B ILE 44  ? B ILE 44  
227 1 Y 1 B PRO 45  ? B PRO 45  
228 1 Y 1 B SER 46  ? B SER 46  
229 1 Y 1 B PRO 47  ? B PRO 47  
230 1 Y 1 B THR 48  ? B THR 48  
231 1 Y 1 B GLN 49  ? B GLN 49  
232 1 Y 1 B LYS 50  ? B LYS 50  
233 1 Y 1 B GLU 51  ? B GLU 51  
234 1 Y 1 B LYS 52  ? B LYS 52  
235 1 Y 1 B GLU 53  ? B GLU 53  
236 1 Y 1 B LYS 54  ? B LYS 54  
237 1 Y 1 B LYS 55  ? B LYS 55  
238 1 Y 1 B LYS 56  ? B LYS 56  
239 1 Y 1 B ARG 57  ? B ARG 57  
240 1 Y 1 B PRO 58  ? B PRO 58  
241 1 Y 1 B MET 59  ? B MET 59  
242 1 Y 1 B SER 60  ? B SER 60  
243 1 Y 1 B GLN 61  ? B GLN 61  
244 1 Y 1 B ILE 62  ? B ILE 62  
245 1 Y 1 B SER 63  ? B SER 63  
246 1 Y 1 B GLY 64  ? B GLY 64  
247 1 Y 1 B VAL 65  ? B VAL 65  
248 1 Y 1 B LYS 66  ? B LYS 66  
249 1 Y 1 B LYS 67  ? B LYS 67  
250 1 Y 1 B LEU 68  ? B LEU 68  
251 1 Y 1 B MET 69  ? B MET 69  
252 1 Y 1 B HIS 70  ? B HIS 70  
253 1 Y 1 B SER 71  ? B SER 71  
254 1 Y 1 B SER 72  ? B SER 72  
255 1 Y 1 B SER 73  ? B SER 73  
256 1 Y 1 B LEU 74  ? B LEU 74  
257 1 Y 1 B THR 75  ? B THR 75  
258 1 Y 1 B ASN 76  ? B ASN 76  
259 1 Y 1 B SER 77  ? B SER 77  
260 1 Y 1 B SER 78  ? B SER 78  
261 1 Y 1 B ILE 79  ? B ILE 79  
262 1 Y 1 B PRO 80  ? B PRO 80  
263 1 Y 1 B ARG 81  ? B ARG 81  
264 1 Y 1 B PHE 82  ? B PHE 82  
265 1 Y 1 B GLY 83  ? B GLY 83  
266 1 Y 1 B VAL 84  ? B VAL 84  
267 1 Y 1 B LYS 85  ? B LYS 85  
268 1 Y 1 B THR 86  ? B THR 86  
269 1 Y 1 B GLU 87  ? B GLU 87  
270 1 Y 1 B GLN 88  ? B GLN 88  
271 1 Y 1 B GLU 89  ? B GLU 89  
272 1 Y 1 B ASP 90  ? B ASP 90  
273 1 Y 1 B GLN 412 ? B GLN 412 
274 1 Y 1 B SER 413 ? B SER 413 
275 1 Y 1 B PRO 414 ? B PRO 414 
276 1 Y 1 B SER 415 ? B SER 415 
277 1 Y 1 B PRO 416 ? B PRO 416 
278 1 Y 1 B ALA 417 ? B ALA 417 
279 1 Y 1 B PRO 418 ? B PRO 418 
280 1 Y 1 B ASP 419 ? B ASP 419 
281 1 Y 1 B ASP 420 ? B ASP 420 
282 1 Y 1 B PRO 421 ? B PRO 421 
283 1 Y 1 B GLU 422 ? B GLU 422 
284 1 Y 1 B GLU 423 ? B GLU 423 
285 1 Y 1 B GLY 424 ? B GLY 424 
286 1 Y 1 B ARG 425 ? B ARG 425 
287 1 Y 1 B GLN 426 ? B GLN 426 
288 1 Y 1 B GLY 427 ? B GLY 427 
289 1 Y 1 B GLN 428 ? B GLN 428 
290 1 Y 1 B THR 429 ? B THR 429 
291 1 Y 1 B GLU 430 ? B GLU 430 
292 1 Y 1 B LYS 431 ? B LYS 431 
293 1 Y 1 B PHE 432 ? B PHE 432 
294 1 Y 1 B GLN 433 ? B GLN 433 
295 1 Y 1 B PHE 434 ? B PHE 434 
296 1 Y 1 B GLU 435 ? B GLU 435 
297 1 Y 1 B LEU 436 ? B LEU 436 
298 1 Y 1 B THR 437 ? B THR 437 
299 1 Y 1 B LEU 438 ? B LEU 438 
300 1 Y 1 B GLU 439 ? B GLU 439 
301 1 Y 1 B GLU 440 ? B GLU 440 
302 1 Y 1 B ASP 441 ? B ASP 441 
303 1 Y 1 B GLY 442 ? B GLY 442 
304 1 Y 1 B GLU 443 ? B GLU 443 
305 1 Y 1 B SER 444 ? B SER 444 
306 1 Y 1 B ASP 445 ? B ASP 445 
307 1 Y 1 B THR 446 ? B THR 446 
308 1 Y 1 B GLU 447 ? B GLU 447 
309 1 Y 1 B LYS 448 ? B LYS 448 
310 1 Y 1 B ASP 449 ? B ASP 449 
311 1 Y 1 B SER 450 ? B SER 450 
312 1 Y 1 B GLY 451 ? B GLY 451 
313 1 Y 1 B SER 452 ? B SER 452 
314 1 Y 1 B GLN 453 ? B GLN 453 
315 1 Y 1 B VAL 454 ? B VAL 454 
316 1 Y 1 B GLU 455 ? B GLU 455 
317 1 Y 1 B GLU 456 ? B GLU 456 
318 1 Y 1 B ASP 457 ? B ASP 457 
319 1 Y 1 B THR 458 ? B THR 458 
320 1 Y 1 B SER 459 ? B SER 459 
321 1 Y 1 B CYS 460 ? B CYS 460 
322 1 Y 1 B SER 461 ? B SER 461 
323 1 Y 1 B ASP 462 ? B ASP 462 
324 1 Y 1 B SER 463 ? B SER 463 
325 1 Y 1 B LYS 464 ? B LYS 464 
326 1 Y 1 B THR 465 ? B THR 465 
327 1 Y 1 B LEU 466 ? B LEU 466 
328 1 Y 1 B CYS 467 ? B CYS 467 
329 1 Y 1 B THR 468 ? B THR 468 
330 1 Y 1 B GLN 469 ? B GLN 469 
331 1 Y 1 B ASP 470 ? B ASP 470 
332 1 Y 1 B SER 471 ? B SER 471 
333 1 Y 1 B GLU 472 ? B GLU 472 
334 1 Y 1 B SER 473 ? B SER 473 
335 1 Y 1 B THR 474 ? B THR 474 
336 1 Y 1 B GLU 475 ? B GLU 475 
337 1 Y 1 B ILE 476 ? B ILE 476 
338 1 Y 1 B PRO 477 ? B PRO 477 
339 1 Y 1 B LEU 478 ? B LEU 478 
340 1 Y 1 B ASP 479 ? B ASP 479 
341 1 Y 1 B GLU 480 ? B GLU 480 
342 1 Y 1 B GLN 481 ? B GLN 481 
343 1 Y 1 B VAL 482 ? B VAL 482 
344 1 Y 1 B GLU 483 ? B GLU 483 
345 1 Y 1 B GLU 484 ? B GLU 484 
346 1 Y 1 B GLU 485 ? B GLU 485 
347 1 Y 1 B ALA 486 ? B ALA 486 
348 1 Y 1 B VAL 487 ? B VAL 487 
349 1 Y 1 B GLY 488 ? B GLY 488 
350 1 Y 1 B GLU 489 ? B GLU 489 
351 1 Y 1 B GLU 490 ? B GLU 490 
352 1 Y 1 B GLU 491 ? B GLU 491 
353 1 Y 1 B GLU 492 ? B GLU 492 
354 1 Y 1 B SER 493 ? B SER 493 
355 1 Y 1 B GLN 494 ? B GLN 494 
356 1 Y 1 B PRO 495 ? B PRO 495 
357 1 Y 1 B GLU 496 ? B GLU 496 
358 1 Y 1 B ALA 497 ? B ALA 497 
359 1 Y 1 B CYS 498 ? B CYS 498 
360 1 Y 1 B VAL 499 ? B VAL 499 
361 1 Y 1 B ILE 500 ? B ILE 500 
362 1 Y 1 B ASP 501 ? B ASP 501 
363 1 Y 1 B ASP 502 ? B ASP 502 
364 1 Y 1 B ARG 503 ? B ARG 503 
365 1 Y 1 B SER 504 ? B SER 504 
366 1 Y 1 B PRO 505 ? B PRO 505 
367 1 Y 1 B ASP 506 ? B ASP 506 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1EKX O33  O  N N 1   
A1EKX C30  C  N N 2   
A1EKX O31  O  N N 3   
A1EKX C32  C  N N 4   
A1EKX C29  C  Y N 5   
A1EKX C28  C  Y N 6   
A1EKX N34  N  Y N 7   
A1EKX C35  C  Y N 8   
A1EKX C27  C  Y N 9   
A1EKX O26  O  N N 10  
A1EKX C25  C  Y N 11  
A1EKX C2   C  Y N 12  
A1EKX O1   O  N N 13  
A1EKX C6   C  Y N 14  
A1EKX O7   O  Y N 15  
A1EKX C8   C  Y N 16  
A1EKX C24  C  Y N 17  
A1EKX C5   C  Y N 18  
A1EKX C4   C  Y N 19  
A1EKX C3   C  Y N 20  
A1EKX C9   C  Y N 21  
A1EKX C23  C  Y N 22  
A1EKX C22  C  Y N 23  
A1EKX C17  C  Y N 24  
A1EKX O18  O  N N 25  
A1EKX F21  F  N N 26  
A1EKX F20  F  N N 27  
A1EKX C19  C  N N 28  
A1EKX C11  C  Y N 29  
A1EKX C10  C  Y N 30  
A1EKX O12  O  N N 31  
A1EKX C13  C  N N 32  
A1EKX C14  C  N N 33  
A1EKX C16  C  N N 34  
A1EKX C15  C  N N 35  
A1EKX H2   H  N N 36  
A1EKX H1   H  N N 37  
A1EKX H3   H  N N 38  
A1EKX H4   H  N N 39  
A1EKX H5   H  N N 40  
A1EKX H6   H  N N 41  
A1EKX H7   H  N N 42  
A1EKX H8   H  N N 43  
A1EKX H9   H  N N 44  
A1EKX H10  H  N N 45  
A1EKX H11  H  N N 46  
A1EKX H12  H  N N 47  
A1EKX H13  H  N N 48  
A1EKX H14  H  N N 49  
A1EKX H15  H  N N 50  
A1EKX H16  H  N N 51  
A1EKX H18  H  N N 52  
A1EKX H19  H  N N 53  
A1EKX H20  H  N N 54  
ALA   N    N  N N 55  
ALA   CA   C  N S 56  
ALA   C    C  N N 57  
ALA   O    O  N N 58  
ALA   CB   C  N N 59  
ALA   OXT  O  N N 60  
ALA   H    H  N N 61  
ALA   H2   H  N N 62  
ALA   HA   H  N N 63  
ALA   HB1  H  N N 64  
ALA   HB2  H  N N 65  
ALA   HB3  H  N N 66  
ALA   HXT  H  N N 67  
ARG   N    N  N N 68  
ARG   CA   C  N S 69  
ARG   C    C  N N 70  
ARG   O    O  N N 71  
ARG   CB   C  N N 72  
ARG   CG   C  N N 73  
ARG   CD   C  N N 74  
ARG   NE   N  N N 75  
ARG   CZ   C  N N 76  
ARG   NH1  N  N N 77  
ARG   NH2  N  N N 78  
ARG   OXT  O  N N 79  
ARG   H    H  N N 80  
ARG   H2   H  N N 81  
ARG   HA   H  N N 82  
ARG   HB2  H  N N 83  
ARG   HB3  H  N N 84  
ARG   HG2  H  N N 85  
ARG   HG3  H  N N 86  
ARG   HD2  H  N N 87  
ARG   HD3  H  N N 88  
ARG   HE   H  N N 89  
ARG   HH11 H  N N 90  
ARG   HH12 H  N N 91  
ARG   HH21 H  N N 92  
ARG   HH22 H  N N 93  
ARG   HXT  H  N N 94  
ASN   N    N  N N 95  
ASN   CA   C  N S 96  
ASN   C    C  N N 97  
ASN   O    O  N N 98  
ASN   CB   C  N N 99  
ASN   CG   C  N N 100 
ASN   OD1  O  N N 101 
ASN   ND2  N  N N 102 
ASN   OXT  O  N N 103 
ASN   H    H  N N 104 
ASN   H2   H  N N 105 
ASN   HA   H  N N 106 
ASN   HB2  H  N N 107 
ASN   HB3  H  N N 108 
ASN   HD21 H  N N 109 
ASN   HD22 H  N N 110 
ASN   HXT  H  N N 111 
ASP   N    N  N N 112 
ASP   CA   C  N S 113 
ASP   C    C  N N 114 
ASP   O    O  N N 115 
ASP   CB   C  N N 116 
ASP   CG   C  N N 117 
ASP   OD1  O  N N 118 
ASP   OD2  O  N N 119 
ASP   OXT  O  N N 120 
ASP   H    H  N N 121 
ASP   H2   H  N N 122 
ASP   HA   H  N N 123 
ASP   HB2  H  N N 124 
ASP   HB3  H  N N 125 
ASP   HD2  H  N N 126 
ASP   HXT  H  N N 127 
CYS   N    N  N N 128 
CYS   CA   C  N R 129 
CYS   C    C  N N 130 
CYS   O    O  N N 131 
CYS   CB   C  N N 132 
CYS   SG   S  N N 133 
CYS   OXT  O  N N 134 
CYS   H    H  N N 135 
CYS   H2   H  N N 136 
CYS   HA   H  N N 137 
CYS   HB2  H  N N 138 
CYS   HB3  H  N N 139 
CYS   HG   H  N N 140 
CYS   HXT  H  N N 141 
GLN   N    N  N N 142 
GLN   CA   C  N S 143 
GLN   C    C  N N 144 
GLN   O    O  N N 145 
GLN   CB   C  N N 146 
GLN   CG   C  N N 147 
GLN   CD   C  N N 148 
GLN   OE1  O  N N 149 
GLN   NE2  N  N N 150 
GLN   OXT  O  N N 151 
GLN   H    H  N N 152 
GLN   H2   H  N N 153 
GLN   HA   H  N N 154 
GLN   HB2  H  N N 155 
GLN   HB3  H  N N 156 
GLN   HG2  H  N N 157 
GLN   HG3  H  N N 158 
GLN   HE21 H  N N 159 
GLN   HE22 H  N N 160 
GLN   HXT  H  N N 161 
GLU   N    N  N N 162 
GLU   CA   C  N S 163 
GLU   C    C  N N 164 
GLU   O    O  N N 165 
GLU   CB   C  N N 166 
GLU   CG   C  N N 167 
GLU   CD   C  N N 168 
GLU   OE1  O  N N 169 
GLU   OE2  O  N N 170 
GLU   OXT  O  N N 171 
GLU   H    H  N N 172 
GLU   H2   H  N N 173 
GLU   HA   H  N N 174 
GLU   HB2  H  N N 175 
GLU   HB3  H  N N 176 
GLU   HG2  H  N N 177 
GLU   HG3  H  N N 178 
GLU   HE2  H  N N 179 
GLU   HXT  H  N N 180 
GLY   N    N  N N 181 
GLY   CA   C  N N 182 
GLY   C    C  N N 183 
GLY   O    O  N N 184 
GLY   OXT  O  N N 185 
GLY   H    H  N N 186 
GLY   H2   H  N N 187 
GLY   HA2  H  N N 188 
GLY   HA3  H  N N 189 
GLY   HXT  H  N N 190 
HIS   N    N  N N 191 
HIS   CA   C  N S 192 
HIS   C    C  N N 193 
HIS   O    O  N N 194 
HIS   CB   C  N N 195 
HIS   CG   C  Y N 196 
HIS   ND1  N  Y N 197 
HIS   CD2  C  Y N 198 
HIS   CE1  C  Y N 199 
HIS   NE2  N  Y N 200 
HIS   OXT  O  N N 201 
HIS   H    H  N N 202 
HIS   H2   H  N N 203 
HIS   HA   H  N N 204 
HIS   HB2  H  N N 205 
HIS   HB3  H  N N 206 
HIS   HD1  H  N N 207 
HIS   HD2  H  N N 208 
HIS   HE1  H  N N 209 
HIS   HE2  H  N N 210 
HIS   HXT  H  N N 211 
HOH   O    O  N N 212 
HOH   H1   H  N N 213 
HOH   H2   H  N N 214 
ILE   N    N  N N 215 
ILE   CA   C  N S 216 
ILE   C    C  N N 217 
ILE   O    O  N N 218 
ILE   CB   C  N S 219 
ILE   CG1  C  N N 220 
ILE   CG2  C  N N 221 
ILE   CD1  C  N N 222 
ILE   OXT  O  N N 223 
ILE   H    H  N N 224 
ILE   H2   H  N N 225 
ILE   HA   H  N N 226 
ILE   HB   H  N N 227 
ILE   HG12 H  N N 228 
ILE   HG13 H  N N 229 
ILE   HG21 H  N N 230 
ILE   HG22 H  N N 231 
ILE   HG23 H  N N 232 
ILE   HD11 H  N N 233 
ILE   HD12 H  N N 234 
ILE   HD13 H  N N 235 
ILE   HXT  H  N N 236 
LEU   N    N  N N 237 
LEU   CA   C  N S 238 
LEU   C    C  N N 239 
LEU   O    O  N N 240 
LEU   CB   C  N N 241 
LEU   CG   C  N N 242 
LEU   CD1  C  N N 243 
LEU   CD2  C  N N 244 
LEU   OXT  O  N N 245 
LEU   H    H  N N 246 
LEU   H2   H  N N 247 
LEU   HA   H  N N 248 
LEU   HB2  H  N N 249 
LEU   HB3  H  N N 250 
LEU   HG   H  N N 251 
LEU   HD11 H  N N 252 
LEU   HD12 H  N N 253 
LEU   HD13 H  N N 254 
LEU   HD21 H  N N 255 
LEU   HD22 H  N N 256 
LEU   HD23 H  N N 257 
LEU   HXT  H  N N 258 
LYS   N    N  N N 259 
LYS   CA   C  N S 260 
LYS   C    C  N N 261 
LYS   O    O  N N 262 
LYS   CB   C  N N 263 
LYS   CG   C  N N 264 
LYS   CD   C  N N 265 
LYS   CE   C  N N 266 
LYS   NZ   N  N N 267 
LYS   OXT  O  N N 268 
LYS   H    H  N N 269 
LYS   H2   H  N N 270 
LYS   HA   H  N N 271 
LYS   HB2  H  N N 272 
LYS   HB3  H  N N 273 
LYS   HG2  H  N N 274 
LYS   HG3  H  N N 275 
LYS   HD2  H  N N 276 
LYS   HD3  H  N N 277 
LYS   HE2  H  N N 278 
LYS   HE3  H  N N 279 
LYS   HZ1  H  N N 280 
LYS   HZ2  H  N N 281 
LYS   HZ3  H  N N 282 
LYS   HXT  H  N N 283 
MET   N    N  N N 284 
MET   CA   C  N S 285 
MET   C    C  N N 286 
MET   O    O  N N 287 
MET   CB   C  N N 288 
MET   CG   C  N N 289 
MET   SD   S  N N 290 
MET   CE   C  N N 291 
MET   OXT  O  N N 292 
MET   H    H  N N 293 
MET   H2   H  N N 294 
MET   HA   H  N N 295 
MET   HB2  H  N N 296 
MET   HB3  H  N N 297 
MET   HG2  H  N N 298 
MET   HG3  H  N N 299 
MET   HE1  H  N N 300 
MET   HE2  H  N N 301 
MET   HE3  H  N N 302 
MET   HXT  H  N N 303 
MG    MG   MG N N 304 
PHE   N    N  N N 305 
PHE   CA   C  N S 306 
PHE   C    C  N N 307 
PHE   O    O  N N 308 
PHE   CB   C  N N 309 
PHE   CG   C  Y N 310 
PHE   CD1  C  Y N 311 
PHE   CD2  C  Y N 312 
PHE   CE1  C  Y N 313 
PHE   CE2  C  Y N 314 
PHE   CZ   C  Y N 315 
PHE   OXT  O  N N 316 
PHE   H    H  N N 317 
PHE   H2   H  N N 318 
PHE   HA   H  N N 319 
PHE   HB2  H  N N 320 
PHE   HB3  H  N N 321 
PHE   HD1  H  N N 322 
PHE   HD2  H  N N 323 
PHE   HE1  H  N N 324 
PHE   HE2  H  N N 325 
PHE   HZ   H  N N 326 
PHE   HXT  H  N N 327 
PRO   N    N  N N 328 
PRO   CA   C  N S 329 
PRO   C    C  N N 330 
PRO   O    O  N N 331 
PRO   CB   C  N N 332 
PRO   CG   C  N N 333 
PRO   CD   C  N N 334 
PRO   OXT  O  N N 335 
PRO   H    H  N N 336 
PRO   HA   H  N N 337 
PRO   HB2  H  N N 338 
PRO   HB3  H  N N 339 
PRO   HG2  H  N N 340 
PRO   HG3  H  N N 341 
PRO   HD2  H  N N 342 
PRO   HD3  H  N N 343 
PRO   HXT  H  N N 344 
SER   N    N  N N 345 
SER   CA   C  N S 346 
SER   C    C  N N 347 
SER   O    O  N N 348 
SER   CB   C  N N 349 
SER   OG   O  N N 350 
SER   OXT  O  N N 351 
SER   H    H  N N 352 
SER   H2   H  N N 353 
SER   HA   H  N N 354 
SER   HB2  H  N N 355 
SER   HB3  H  N N 356 
SER   HG   H  N N 357 
SER   HXT  H  N N 358 
THR   N    N  N N 359 
THR   CA   C  N S 360 
THR   C    C  N N 361 
THR   O    O  N N 362 
THR   CB   C  N R 363 
THR   OG1  O  N N 364 
THR   CG2  C  N N 365 
THR   OXT  O  N N 366 
THR   H    H  N N 367 
THR   H2   H  N N 368 
THR   HA   H  N N 369 
THR   HB   H  N N 370 
THR   HG1  H  N N 371 
THR   HG21 H  N N 372 
THR   HG22 H  N N 373 
THR   HG23 H  N N 374 
THR   HXT  H  N N 375 
TRP   N    N  N N 376 
TRP   CA   C  N S 377 
TRP   C    C  N N 378 
TRP   O    O  N N 379 
TRP   CB   C  N N 380 
TRP   CG   C  Y N 381 
TRP   CD1  C  Y N 382 
TRP   CD2  C  Y N 383 
TRP   NE1  N  Y N 384 
TRP   CE2  C  Y N 385 
TRP   CE3  C  Y N 386 
TRP   CZ2  C  Y N 387 
TRP   CZ3  C  Y N 388 
TRP   CH2  C  Y N 389 
TRP   OXT  O  N N 390 
TRP   H    H  N N 391 
TRP   H2   H  N N 392 
TRP   HA   H  N N 393 
TRP   HB2  H  N N 394 
TRP   HB3  H  N N 395 
TRP   HD1  H  N N 396 
TRP   HE1  H  N N 397 
TRP   HE3  H  N N 398 
TRP   HZ2  H  N N 399 
TRP   HZ3  H  N N 400 
TRP   HH2  H  N N 401 
TRP   HXT  H  N N 402 
TYR   N    N  N N 403 
TYR   CA   C  N S 404 
TYR   C    C  N N 405 
TYR   O    O  N N 406 
TYR   CB   C  N N 407 
TYR   CG   C  Y N 408 
TYR   CD1  C  Y N 409 
TYR   CD2  C  Y N 410 
TYR   CE1  C  Y N 411 
TYR   CE2  C  Y N 412 
TYR   CZ   C  Y N 413 
TYR   OH   O  N N 414 
TYR   OXT  O  N N 415 
TYR   H    H  N N 416 
TYR   H2   H  N N 417 
TYR   HA   H  N N 418 
TYR   HB2  H  N N 419 
TYR   HB3  H  N N 420 
TYR   HD1  H  N N 421 
TYR   HD2  H  N N 422 
TYR   HE1  H  N N 423 
TYR   HE2  H  N N 424 
TYR   HH   H  N N 425 
TYR   HXT  H  N N 426 
VAL   N    N  N N 427 
VAL   CA   C  N S 428 
VAL   C    C  N N 429 
VAL   O    O  N N 430 
VAL   CB   C  N N 431 
VAL   CG1  C  N N 432 
VAL   CG2  C  N N 433 
VAL   OXT  O  N N 434 
VAL   H    H  N N 435 
VAL   H2   H  N N 436 
VAL   HA   H  N N 437 
VAL   HB   H  N N 438 
VAL   HG11 H  N N 439 
VAL   HG12 H  N N 440 
VAL   HG13 H  N N 441 
VAL   HG21 H  N N 442 
VAL   HG22 H  N N 443 
VAL   HG23 H  N N 444 
VAL   HXT  H  N N 445 
ZN    ZN   ZN N N 446 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1EKX O33 C30  doub N N 1   
A1EKX C30 O31  sing N N 2   
A1EKX C30 C29  sing N N 3   
A1EKX O31 C32  sing N N 4   
A1EKX C29 C28  doub Y N 5   
A1EKX C29 N34  sing Y N 6   
A1EKX C28 C27  sing Y N 7   
A1EKX N34 C35  sing Y N 8   
A1EKX C35 C27  doub Y N 9   
A1EKX C27 O26  sing N N 10  
A1EKX O26 C25  sing N N 11  
A1EKX C25 C2   doub Y N 12  
A1EKX C25 C6   sing Y N 13  
A1EKX C2  O1   sing N N 14  
A1EKX C2  C3   sing Y N 15  
A1EKX C6  O7   sing Y N 16  
A1EKX C6  C5   doub Y N 17  
A1EKX O7  C8   sing Y N 18  
A1EKX C8  C24  doub Y N 19  
A1EKX C8  C9   sing N N 20  
A1EKX C24 C5   sing Y N 21  
A1EKX C5  C4   sing Y N 22  
A1EKX C4  C3   doub Y N 23  
A1EKX C9  C23  doub Y N 24  
A1EKX C9  C10  sing Y N 25  
A1EKX C23 C22  sing Y N 26  
A1EKX C22 C17  doub Y N 27  
A1EKX C17 O18  sing N N 28  
A1EKX C17 C11  sing Y N 29  
A1EKX O18 C19  sing N N 30  
A1EKX F21 C19  sing N N 31  
A1EKX F20 C19  sing N N 32  
A1EKX C11 C10  doub Y N 33  
A1EKX C11 O12  sing N N 34  
A1EKX O12 C13  sing N N 35  
A1EKX C13 C14  sing N N 36  
A1EKX C14 C16  sing N N 37  
A1EKX C14 C15  doub N N 38  
A1EKX C16 C15  sing N N 39  
A1EKX C32 H2   sing N N 40  
A1EKX C32 H1   sing N N 41  
A1EKX C32 H3   sing N N 42  
A1EKX C28 H4   sing N N 43  
A1EKX N34 H5   sing N N 44  
A1EKX C35 H6   sing N N 45  
A1EKX O1  H7   sing N N 46  
A1EKX C24 H8   sing N N 47  
A1EKX C4  H9   sing N N 48  
A1EKX C3  H10  sing N N 49  
A1EKX C23 H11  sing N N 50  
A1EKX C22 H12  sing N N 51  
A1EKX C19 H13  sing N N 52  
A1EKX C10 H14  sing N N 53  
A1EKX C13 H15  sing N N 54  
A1EKX C13 H16  sing N N 55  
A1EKX C16 H18  sing N N 56  
A1EKX C16 H19  sing N N 57  
A1EKX C15 H20  sing N N 58  
ALA   N   CA   sing N N 59  
ALA   N   H    sing N N 60  
ALA   N   H2   sing N N 61  
ALA   CA  C    sing N N 62  
ALA   CA  CB   sing N N 63  
ALA   CA  HA   sing N N 64  
ALA   C   O    doub N N 65  
ALA   C   OXT  sing N N 66  
ALA   CB  HB1  sing N N 67  
ALA   CB  HB2  sing N N 68  
ALA   CB  HB3  sing N N 69  
ALA   OXT HXT  sing N N 70  
ARG   N   CA   sing N N 71  
ARG   N   H    sing N N 72  
ARG   N   H2   sing N N 73  
ARG   CA  C    sing N N 74  
ARG   CA  CB   sing N N 75  
ARG   CA  HA   sing N N 76  
ARG   C   O    doub N N 77  
ARG   C   OXT  sing N N 78  
ARG   CB  CG   sing N N 79  
ARG   CB  HB2  sing N N 80  
ARG   CB  HB3  sing N N 81  
ARG   CG  CD   sing N N 82  
ARG   CG  HG2  sing N N 83  
ARG   CG  HG3  sing N N 84  
ARG   CD  NE   sing N N 85  
ARG   CD  HD2  sing N N 86  
ARG   CD  HD3  sing N N 87  
ARG   NE  CZ   sing N N 88  
ARG   NE  HE   sing N N 89  
ARG   CZ  NH1  sing N N 90  
ARG   CZ  NH2  doub N N 91  
ARG   NH1 HH11 sing N N 92  
ARG   NH1 HH12 sing N N 93  
ARG   NH2 HH21 sing N N 94  
ARG   NH2 HH22 sing N N 95  
ARG   OXT HXT  sing N N 96  
ASN   N   CA   sing N N 97  
ASN   N   H    sing N N 98  
ASN   N   H2   sing N N 99  
ASN   CA  C    sing N N 100 
ASN   CA  CB   sing N N 101 
ASN   CA  HA   sing N N 102 
ASN   C   O    doub N N 103 
ASN   C   OXT  sing N N 104 
ASN   CB  CG   sing N N 105 
ASN   CB  HB2  sing N N 106 
ASN   CB  HB3  sing N N 107 
ASN   CG  OD1  doub N N 108 
ASN   CG  ND2  sing N N 109 
ASN   ND2 HD21 sing N N 110 
ASN   ND2 HD22 sing N N 111 
ASN   OXT HXT  sing N N 112 
ASP   N   CA   sing N N 113 
ASP   N   H    sing N N 114 
ASP   N   H2   sing N N 115 
ASP   CA  C    sing N N 116 
ASP   CA  CB   sing N N 117 
ASP   CA  HA   sing N N 118 
ASP   C   O    doub N N 119 
ASP   C   OXT  sing N N 120 
ASP   CB  CG   sing N N 121 
ASP   CB  HB2  sing N N 122 
ASP   CB  HB3  sing N N 123 
ASP   CG  OD1  doub N N 124 
ASP   CG  OD2  sing N N 125 
ASP   OD2 HD2  sing N N 126 
ASP   OXT HXT  sing N N 127 
CYS   N   CA   sing N N 128 
CYS   N   H    sing N N 129 
CYS   N   H2   sing N N 130 
CYS   CA  C    sing N N 131 
CYS   CA  CB   sing N N 132 
CYS   CA  HA   sing N N 133 
CYS   C   O    doub N N 134 
CYS   C   OXT  sing N N 135 
CYS   CB  SG   sing N N 136 
CYS   CB  HB2  sing N N 137 
CYS   CB  HB3  sing N N 138 
CYS   SG  HG   sing N N 139 
CYS   OXT HXT  sing N N 140 
GLN   N   CA   sing N N 141 
GLN   N   H    sing N N 142 
GLN   N   H2   sing N N 143 
GLN   CA  C    sing N N 144 
GLN   CA  CB   sing N N 145 
GLN   CA  HA   sing N N 146 
GLN   C   O    doub N N 147 
GLN   C   OXT  sing N N 148 
GLN   CB  CG   sing N N 149 
GLN   CB  HB2  sing N N 150 
GLN   CB  HB3  sing N N 151 
GLN   CG  CD   sing N N 152 
GLN   CG  HG2  sing N N 153 
GLN   CG  HG3  sing N N 154 
GLN   CD  OE1  doub N N 155 
GLN   CD  NE2  sing N N 156 
GLN   NE2 HE21 sing N N 157 
GLN   NE2 HE22 sing N N 158 
GLN   OXT HXT  sing N N 159 
GLU   N   CA   sing N N 160 
GLU   N   H    sing N N 161 
GLU   N   H2   sing N N 162 
GLU   CA  C    sing N N 163 
GLU   CA  CB   sing N N 164 
GLU   CA  HA   sing N N 165 
GLU   C   O    doub N N 166 
GLU   C   OXT  sing N N 167 
GLU   CB  CG   sing N N 168 
GLU   CB  HB2  sing N N 169 
GLU   CB  HB3  sing N N 170 
GLU   CG  CD   sing N N 171 
GLU   CG  HG2  sing N N 172 
GLU   CG  HG3  sing N N 173 
GLU   CD  OE1  doub N N 174 
GLU   CD  OE2  sing N N 175 
GLU   OE2 HE2  sing N N 176 
GLU   OXT HXT  sing N N 177 
GLY   N   CA   sing N N 178 
GLY   N   H    sing N N 179 
GLY   N   H2   sing N N 180 
GLY   CA  C    sing N N 181 
GLY   CA  HA2  sing N N 182 
GLY   CA  HA3  sing N N 183 
GLY   C   O    doub N N 184 
GLY   C   OXT  sing N N 185 
GLY   OXT HXT  sing N N 186 
HIS   N   CA   sing N N 187 
HIS   N   H    sing N N 188 
HIS   N   H2   sing N N 189 
HIS   CA  C    sing N N 190 
HIS   CA  CB   sing N N 191 
HIS   CA  HA   sing N N 192 
HIS   C   O    doub N N 193 
HIS   C   OXT  sing N N 194 
HIS   CB  CG   sing N N 195 
HIS   CB  HB2  sing N N 196 
HIS   CB  HB3  sing N N 197 
HIS   CG  ND1  sing Y N 198 
HIS   CG  CD2  doub Y N 199 
HIS   ND1 CE1  doub Y N 200 
HIS   ND1 HD1  sing N N 201 
HIS   CD2 NE2  sing Y N 202 
HIS   CD2 HD2  sing N N 203 
HIS   CE1 NE2  sing Y N 204 
HIS   CE1 HE1  sing N N 205 
HIS   NE2 HE2  sing N N 206 
HIS   OXT HXT  sing N N 207 
HOH   O   H1   sing N N 208 
HOH   O   H2   sing N N 209 
ILE   N   CA   sing N N 210 
ILE   N   H    sing N N 211 
ILE   N   H2   sing N N 212 
ILE   CA  C    sing N N 213 
ILE   CA  CB   sing N N 214 
ILE   CA  HA   sing N N 215 
ILE   C   O    doub N N 216 
ILE   C   OXT  sing N N 217 
ILE   CB  CG1  sing N N 218 
ILE   CB  CG2  sing N N 219 
ILE   CB  HB   sing N N 220 
ILE   CG1 CD1  sing N N 221 
ILE   CG1 HG12 sing N N 222 
ILE   CG1 HG13 sing N N 223 
ILE   CG2 HG21 sing N N 224 
ILE   CG2 HG22 sing N N 225 
ILE   CG2 HG23 sing N N 226 
ILE   CD1 HD11 sing N N 227 
ILE   CD1 HD12 sing N N 228 
ILE   CD1 HD13 sing N N 229 
ILE   OXT HXT  sing N N 230 
LEU   N   CA   sing N N 231 
LEU   N   H    sing N N 232 
LEU   N   H2   sing N N 233 
LEU   CA  C    sing N N 234 
LEU   CA  CB   sing N N 235 
LEU   CA  HA   sing N N 236 
LEU   C   O    doub N N 237 
LEU   C   OXT  sing N N 238 
LEU   CB  CG   sing N N 239 
LEU   CB  HB2  sing N N 240 
LEU   CB  HB3  sing N N 241 
LEU   CG  CD1  sing N N 242 
LEU   CG  CD2  sing N N 243 
LEU   CG  HG   sing N N 244 
LEU   CD1 HD11 sing N N 245 
LEU   CD1 HD12 sing N N 246 
LEU   CD1 HD13 sing N N 247 
LEU   CD2 HD21 sing N N 248 
LEU   CD2 HD22 sing N N 249 
LEU   CD2 HD23 sing N N 250 
LEU   OXT HXT  sing N N 251 
LYS   N   CA   sing N N 252 
LYS   N   H    sing N N 253 
LYS   N   H2   sing N N 254 
LYS   CA  C    sing N N 255 
LYS   CA  CB   sing N N 256 
LYS   CA  HA   sing N N 257 
LYS   C   O    doub N N 258 
LYS   C   OXT  sing N N 259 
LYS   CB  CG   sing N N 260 
LYS   CB  HB2  sing N N 261 
LYS   CB  HB3  sing N N 262 
LYS   CG  CD   sing N N 263 
LYS   CG  HG2  sing N N 264 
LYS   CG  HG3  sing N N 265 
LYS   CD  CE   sing N N 266 
LYS   CD  HD2  sing N N 267 
LYS   CD  HD3  sing N N 268 
LYS   CE  NZ   sing N N 269 
LYS   CE  HE2  sing N N 270 
LYS   CE  HE3  sing N N 271 
LYS   NZ  HZ1  sing N N 272 
LYS   NZ  HZ2  sing N N 273 
LYS   NZ  HZ3  sing N N 274 
LYS   OXT HXT  sing N N 275 
MET   N   CA   sing N N 276 
MET   N   H    sing N N 277 
MET   N   H2   sing N N 278 
MET   CA  C    sing N N 279 
MET   CA  CB   sing N N 280 
MET   CA  HA   sing N N 281 
MET   C   O    doub N N 282 
MET   C   OXT  sing N N 283 
MET   CB  CG   sing N N 284 
MET   CB  HB2  sing N N 285 
MET   CB  HB3  sing N N 286 
MET   CG  SD   sing N N 287 
MET   CG  HG2  sing N N 288 
MET   CG  HG3  sing N N 289 
MET   SD  CE   sing N N 290 
MET   CE  HE1  sing N N 291 
MET   CE  HE2  sing N N 292 
MET   CE  HE3  sing N N 293 
MET   OXT HXT  sing N N 294 
PHE   N   CA   sing N N 295 
PHE   N   H    sing N N 296 
PHE   N   H2   sing N N 297 
PHE   CA  C    sing N N 298 
PHE   CA  CB   sing N N 299 
PHE   CA  HA   sing N N 300 
PHE   C   O    doub N N 301 
PHE   C   OXT  sing N N 302 
PHE   CB  CG   sing N N 303 
PHE   CB  HB2  sing N N 304 
PHE   CB  HB3  sing N N 305 
PHE   CG  CD1  doub Y N 306 
PHE   CG  CD2  sing Y N 307 
PHE   CD1 CE1  sing Y N 308 
PHE   CD1 HD1  sing N N 309 
PHE   CD2 CE2  doub Y N 310 
PHE   CD2 HD2  sing N N 311 
PHE   CE1 CZ   doub Y N 312 
PHE   CE1 HE1  sing N N 313 
PHE   CE2 CZ   sing Y N 314 
PHE   CE2 HE2  sing N N 315 
PHE   CZ  HZ   sing N N 316 
PHE   OXT HXT  sing N N 317 
PRO   N   CA   sing N N 318 
PRO   N   CD   sing N N 319 
PRO   N   H    sing N N 320 
PRO   CA  C    sing N N 321 
PRO   CA  CB   sing N N 322 
PRO   CA  HA   sing N N 323 
PRO   C   O    doub N N 324 
PRO   C   OXT  sing N N 325 
PRO   CB  CG   sing N N 326 
PRO   CB  HB2  sing N N 327 
PRO   CB  HB3  sing N N 328 
PRO   CG  CD   sing N N 329 
PRO   CG  HG2  sing N N 330 
PRO   CG  HG3  sing N N 331 
PRO   CD  HD2  sing N N 332 
PRO   CD  HD3  sing N N 333 
PRO   OXT HXT  sing N N 334 
SER   N   CA   sing N N 335 
SER   N   H    sing N N 336 
SER   N   H2   sing N N 337 
SER   CA  C    sing N N 338 
SER   CA  CB   sing N N 339 
SER   CA  HA   sing N N 340 
SER   C   O    doub N N 341 
SER   C   OXT  sing N N 342 
SER   CB  OG   sing N N 343 
SER   CB  HB2  sing N N 344 
SER   CB  HB3  sing N N 345 
SER   OG  HG   sing N N 346 
SER   OXT HXT  sing N N 347 
THR   N   CA   sing N N 348 
THR   N   H    sing N N 349 
THR   N   H2   sing N N 350 
THR   CA  C    sing N N 351 
THR   CA  CB   sing N N 352 
THR   CA  HA   sing N N 353 
THR   C   O    doub N N 354 
THR   C   OXT  sing N N 355 
THR   CB  OG1  sing N N 356 
THR   CB  CG2  sing N N 357 
THR   CB  HB   sing N N 358 
THR   OG1 HG1  sing N N 359 
THR   CG2 HG21 sing N N 360 
THR   CG2 HG22 sing N N 361 
THR   CG2 HG23 sing N N 362 
THR   OXT HXT  sing N N 363 
TRP   N   CA   sing N N 364 
TRP   N   H    sing N N 365 
TRP   N   H2   sing N N 366 
TRP   CA  C    sing N N 367 
TRP   CA  CB   sing N N 368 
TRP   CA  HA   sing N N 369 
TRP   C   O    doub N N 370 
TRP   C   OXT  sing N N 371 
TRP   CB  CG   sing N N 372 
TRP   CB  HB2  sing N N 373 
TRP   CB  HB3  sing N N 374 
TRP   CG  CD1  doub Y N 375 
TRP   CG  CD2  sing Y N 376 
TRP   CD1 NE1  sing Y N 377 
TRP   CD1 HD1  sing N N 378 
TRP   CD2 CE2  doub Y N 379 
TRP   CD2 CE3  sing Y N 380 
TRP   NE1 CE2  sing Y N 381 
TRP   NE1 HE1  sing N N 382 
TRP   CE2 CZ2  sing Y N 383 
TRP   CE3 CZ3  doub Y N 384 
TRP   CE3 HE3  sing N N 385 
TRP   CZ2 CH2  doub Y N 386 
TRP   CZ2 HZ2  sing N N 387 
TRP   CZ3 CH2  sing Y N 388 
TRP   CZ3 HZ3  sing N N 389 
TRP   CH2 HH2  sing N N 390 
TRP   OXT HXT  sing N N 391 
TYR   N   CA   sing N N 392 
TYR   N   H    sing N N 393 
TYR   N   H2   sing N N 394 
TYR   CA  C    sing N N 395 
TYR   CA  CB   sing N N 396 
TYR   CA  HA   sing N N 397 
TYR   C   O    doub N N 398 
TYR   C   OXT  sing N N 399 
TYR   CB  CG   sing N N 400 
TYR   CB  HB2  sing N N 401 
TYR   CB  HB3  sing N N 402 
TYR   CG  CD1  doub Y N 403 
TYR   CG  CD2  sing Y N 404 
TYR   CD1 CE1  sing Y N 405 
TYR   CD1 HD1  sing N N 406 
TYR   CD2 CE2  doub Y N 407 
TYR   CD2 HD2  sing N N 408 
TYR   CE1 CZ   doub Y N 409 
TYR   CE1 HE1  sing N N 410 
TYR   CE2 CZ   sing Y N 411 
TYR   CE2 HE2  sing N N 412 
TYR   CZ  OH   sing N N 413 
TYR   OH  HH   sing N N 414 
TYR   OXT HXT  sing N N 415 
VAL   N   CA   sing N N 416 
VAL   N   H    sing N N 417 
VAL   N   H2   sing N N 418 
VAL   CA  C    sing N N 419 
VAL   CA  CB   sing N N 420 
VAL   CA  HA   sing N N 421 
VAL   C   O    doub N N 422 
VAL   C   OXT  sing N N 423 
VAL   CB  CG1  sing N N 424 
VAL   CB  CG2  sing N N 425 
VAL   CB  HB   sing N N 426 
VAL   CG1 HG11 sing N N 427 
VAL   CG1 HG12 sing N N 428 
VAL   CG1 HG13 sing N N 429 
VAL   CG2 HG21 sing N N 430 
VAL   CG2 HG22 sing N N 431 
VAL   CG2 HG23 sing N N 432 
VAL   OXT HXT  sing N N 433 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           22277019 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5WQA 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9LO7 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.017437 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012549 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006161 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 25.62398 1.50364  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F  ? ? 4.90428  4.07044 12.99538 1.63651  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
MG ? ? 9.41153  2.53737 2.59044  63.03566 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 19.97189 1.75589  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 15.80542 1.70748  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 1.23737  29.19336 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
ZN ? ? 24.64596 5.25405 2.14387  29.76375 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . GLN   A 1 88  ? -11.37860 22.05465  -6.10653  1.000 35.27166 ? 88  GLN   A N   1 
ATOM   2    C  CA  . GLN   A 1 88  ? -11.73493 21.07329  -7.12227  1.000 39.75084 ? 88  GLN   A CA  1 
ATOM   3    C  C   . GLN   A 1 88  ? -10.55752 20.67289  -8.01707  1.000 45.21676 ? 88  GLN   A C   1 
ATOM   4    O  O   . GLN   A 1 88  ? -10.27902 19.47965  -8.16935  1.000 33.53667 ? 88  GLN   A O   1 
ATOM   5    C  CB  . GLN   A 1 88  ? -12.88219 21.59062  -7.99429  1.000 44.48944 ? 88  GLN   A CB  1 
ATOM   6    C  CG  . GLN   A 1 88  ? -14.26034 21.11616  -7.54132  1.000 40.77761 ? 88  GLN   A CG  1 
ATOM   7    C  CD  . GLN   A 1 88  ? -15.31297 21.17872  -8.64438  1.000 46.63470 ? 88  GLN   A CD  1 
ATOM   8    O  OE1 . GLN   A 1 88  ? -15.08051 21.74799  -9.70703  1.000 54.26231 ? 88  GLN   A OE1 1 
ATOM   9    N  NE2 . GLN   A 1 88  ? -16.47706 20.58242  -8.39217  1.000 46.69461 ? 88  GLN   A NE2 1 
ATOM   10   N  N   . GLU   A 1 89  ? -9.87101  21.66288  -8.60536  1.000 40.83934 ? 89  GLU   A N   1 
ATOM   11   C  CA  . GLU   A 1 89  ? -8.84191  21.36293  -9.60017  1.000 33.56453 ? 89  GLU   A CA  1 
ATOM   12   C  C   . GLU   A 1 89  ? -7.72297  20.50200  -9.02349  1.000 39.60642 ? 89  GLU   A C   1 
ATOM   13   O  O   . GLU   A 1 89  ? -7.08651  19.73434  -9.76130  1.000 26.73779 ? 89  GLU   A O   1 
ATOM   14   C  CB  . GLU   A 1 89  ? -8.24660  22.65099  -10.16362 1.000 38.50168 ? 89  GLU   A CB  1 
ATOM   15   C  CG  . GLU   A 1 89  ? -9.18141  23.84294  -10.18600 1.000 46.93257 ? 89  GLU   A CG  1 
ATOM   16   C  CD  . GLU   A 1 89  ? -8.40892  25.14842  -10.23044 1.000 51.49670 ? 89  GLU   A CD  1 
ATOM   17   O  OE1 . GLU   A 1 89  ? -7.93396  25.52477  -11.32705 1.000 42.16928 ? 89  GLU   A OE1 1 
ATOM   18   O  OE2 . GLU   A 1 89  ? -8.24474  25.77321  -9.15341  1.000 55.23836 ? 89  GLU   A OE2 1 
ATOM   19   N  N   . ASP   A 1 90  ? -7.44332  20.64645  -7.72132  1.000 40.10298 ? 90  ASP   A N   1 
ATOM   20   C  CA  . ASP   A 1 90  ? -6.48046  19.77311  -7.05620  1.000 34.87263 ? 90  ASP   A CA  1 
ATOM   21   C  C   . ASP   A 1 90  ? -6.99116  18.33708  -7.02144  1.000 32.76338 ? 90  ASP   A C   1 
ATOM   22   O  O   . ASP   A 1 90  ? -6.24667  17.39569  -7.32689  1.000 23.82900 ? 90  ASP   A O   1 
ATOM   23   C  CB  . ASP   A 1 90  ? -6.20624  20.29417  -5.63811  1.000 41.99868 ? 90  ASP   A CB  1 
ATOM   24   C  CG  . ASP   A 1 90  ? -5.67239  19.21331  -4.68751  1.000 54.31935 ? 90  ASP   A CG  1 
ATOM   25   O  OD1 . ASP   A 1 90  ? -4.66882  18.54149  -5.01927  1.000 58.26056 ? 90  ASP   A OD1 1 
ATOM   26   O  OD2 . ASP   A 1 90  ? -6.25745  19.03908  -3.59243  1.000 60.22243 ? 90  ASP   A OD2 1 
ATOM   27   N  N   . VAL   A 1 91  ? -8.26913  18.15979  -6.67496  1.000 28.64409 ? 91  VAL   A N   1 
ATOM   28   C  CA  . VAL   A 1 91  ? -8.86708  16.82865  -6.64641  1.000 30.99901 ? 91  VAL   A CA  1 
ATOM   29   C  C   . VAL   A 1 91  ? -8.88083  16.22177  -8.04715  1.000 27.06968 ? 91  VAL   A C   1 
ATOM   30   O  O   . VAL   A 1 91  ? -8.47725  15.06781  -8.23629  1.000 25.65563 ? 91  VAL   A O   1 
ATOM   31   C  CB  . VAL   A 1 91  ? -10.27519 16.89532  -6.02615  1.000 27.08321 ? 91  VAL   A CB  1 
ATOM   32   C  CG1 . VAL   A 1 91  ? -10.89237 15.51822  -5.93203  1.000 24.02319 ? 91  VAL   A CG1 1 
ATOM   33   C  CG2 . VAL   A 1 91  ? -10.20382 17.52647  -4.65706  1.000 33.05357 ? 91  VAL   A CG2 1 
ATOM   34   N  N   . LEU   A 1 92  ? -9.31399  16.99972  -9.05201  1.000 22.76965 ? 92  LEU   A N   1 
ATOM   35   C  CA  . LEU   A 1 92  ? -9.27031  16.53094  -10.43503 1.000 24.02384 ? 92  LEU   A CA  1 
ATOM   36   C  C   . LEU   A 1 92  ? -7.85740  16.10510  -10.82918 1.000 28.54546 ? 92  LEU   A C   1 
ATOM   37   O  O   . LEU   A 1 92  ? -7.65175  14.99368  -11.33364 1.000 24.99381 ? 92  LEU   A O   1 
ATOM   38   C  CB  . LEU   A 1 92  ? -9.78928  17.60733  -11.39678 1.000 17.25550 ? 92  LEU   A CB  1 
ATOM   39   C  CG  . LEU   A 1 92  ? -9.61903  17.25913  -12.88741 1.000 14.67083 ? 92  LEU   A CG  1 
ATOM   40   C  CD1 . LEU   A 1 92  ? -10.41398 16.00334  -13.29191 1.000 16.12805 ? 92  LEU   A CD1 1 
ATOM   41   C  CD2 . LEU   A 1 92  ? -9.99873  18.43707  -13.79317 1.000 17.12925 ? 92  LEU   A CD2 1 
ATOM   42   N  N   . ALA   A 1 93  ? -6.87200  16.98437  -10.61481 1.000 23.92195 ? 93  ALA   A N   1 
ATOM   43   C  CA  . ALA   A 1 93  ? -5.48577  16.64560  -10.91374 1.000 22.31481 ? 93  ALA   A CA  1 
ATOM   44   C  C   . ALA   A 1 93  ? -5.08112  15.33645  -10.25383 1.000 24.75405 ? 93  ALA   A C   1 
ATOM   45   O  O   . ALA   A 1 93  ? -4.32341  14.54523  -10.83053 1.000 27.90581 ? 93  ALA   A O   1 
ATOM   46   C  CB  . ALA   A 1 93  ? -4.55930  17.78094  -10.46634 1.000 22.02883 ? 93  ALA   A CB  1 
ATOM   47   N  N   . LYS   A 1 94  ? -5.58250  15.09085  -9.04287  1.000 27.70837 ? 94  LYS   A N   1 
ATOM   48   C  CA  . LYS   A 1 94  ? -5.28760  13.84734  -8.34165  1.000 25.92587 ? 94  LYS   A CA  1 
ATOM   49   C  C   . LYS   A 1 94  ? -5.85845  12.64909  -9.08864  1.000 27.68225 ? 94  LYS   A C   1 
ATOM   50   O  O   . LYS   A 1 94  ? -5.18077  11.62768  -9.25622  1.000 25.45797 ? 94  LYS   A O   1 
ATOM   51   C  CB  . LYS   A 1 94  ? -5.85037  13.90922  -6.92443  1.000 25.68067 ? 94  LYS   A CB  1 
ATOM   52   C  CG  . LYS   A 1 94  ? -5.73636  12.61734  -6.13960  1.000 30.61272 ? 94  LYS   A CG  1 
ATOM   53   C  CD  . LYS   A 1 94  ? -4.53171  12.65322  -5.21168  1.000 43.91760 ? 94  LYS   A CD  1 
ATOM   54   C  CE  . LYS   A 1 94  ? -4.68865  13.75830  -4.17325  1.000 50.49939 ? 94  LYS   A CE  1 
ATOM   55   N  NZ  . LYS   A 1 94  ? -3.54195  13.84157  -3.22030  1.000 56.61762 ? 94  LYS   A NZ  1 
ATOM   56   N  N   . GLU   A 1 95  ? -7.10825  12.75647  -9.54109  1.000 22.43696 ? 95  GLU   A N   1 
ATOM   57   C  CA  . GLU   A 1 95  ? -7.73400  11.63639  -10.22927 1.000 24.66079 ? 95  GLU   A CA  1 
ATOM   58   C  C   . GLU   A 1 95  ? -7.07038  11.38429  -11.57174 1.000 19.36906 ? 95  GLU   A C   1 
ATOM   59   O  O   . GLU   A 1 95  ? -6.90810  10.23106  -11.97300 1.000 21.51038 ? 95  GLU   A O   1 
ATOM   60   C  CB  . GLU   A 1 95  ? -9.23840  11.88533  -10.39176 1.000 23.79896 ? 95  GLU   A CB  1 
ATOM   61   C  CG  . GLU   A 1 95  ? -10.02015 11.97491  -9.06493  1.000 28.98709 ? 95  GLU   A CG  1 
ATOM   62   C  CD  . GLU   A 1 95  ? -10.20690 10.62464  -8.34009  1.000 29.68732 ? 95  GLU   A CD  1 
ATOM   63   O  OE1 . GLU   A 1 95  ? -10.35966 9.59339   -9.01323  1.000 26.22371 ? 95  GLU   A OE1 1 
ATOM   64   O  OE2 . GLU   A 1 95  ? -10.22122 10.59225  -7.08661  1.000 37.88058 ? 95  GLU   A OE2 1 
ATOM   65   N  N   . LEU   A 1 96  ? -6.63103  12.43876  -12.25551 1.000 21.92775 ? 96  LEU   A N   1 
ATOM   66   C  CA  . LEU   A 1 96  ? -5.93670  12.25522  -13.52364 1.000 23.12388 ? 96  LEU   A CA  1 
ATOM   67   C  C   . LEU   A 1 96  ? -4.61943  11.50393  -13.36203 1.000 26.29337 ? 96  LEU   A C   1 
ATOM   68   O  O   . LEU   A 1 96  ? -4.06379  11.04856  -14.36725 1.000 23.20928 ? 96  LEU   A O   1 
ATOM   69   C  CB  . LEU   A 1 96  ? -5.73018  13.61167  -14.19854 1.000 18.23177 ? 96  LEU   A CB  1 
ATOM   70   C  CG  . LEU   A 1 96  ? -7.07261  14.18616  -14.63991 1.000 16.70266 ? 96  LEU   A CG  1 
ATOM   71   C  CD1 . LEU   A 1 96  ? -6.93238  15.62108  -15.05856 1.000 20.14158 ? 96  LEU   A CD1 1 
ATOM   72   C  CD2 . LEU   A 1 96  ? -7.62935  13.36255  -15.80009 1.000 21.71887 ? 96  LEU   A CD2 1 
ATOM   73   N  N   . GLU   A 1 97  ? -4.13975  11.31323  -12.12404 1.000 24.52598 ? 97  GLU   A N   1 
ATOM   74   C  CA  . GLU   A 1 97  ? -2.99307  10.44153  -11.88525 1.000 26.48196 ? 97  GLU   A CA  1 
ATOM   75   C  C   . GLU   A 1 97  ? -3.26171  8.98973   -12.26594 1.000 25.29855 ? 97  GLU   A C   1 
ATOM   76   O  O   . GLU   A 1 97  ? -2.30780  8.21226   -12.36860 1.000 26.63039 ? 97  GLU   A O   1 
ATOM   77   C  CB  . GLU   A 1 97  ? -2.56253  10.50128  -10.40598 1.000 29.57424 ? 97  GLU   A CB  1 
ATOM   78   C  CG  . GLU   A 1 97  ? -1.41493  11.49233  -10.11370 1.000 27.37019 ? 97  GLU   A CG  1 
ATOM   79   C  CD  . GLU   A 1 97  ? -1.48909  12.13645  -8.73320  1.000 28.89596 ? 97  GLU   A CD  1 
ATOM   80   O  OE1 . GLU   A 1 97  ? -1.67857  11.41202  -7.72954  1.000 30.69645 ? 97  GLU   A OE1 1 
ATOM   81   O  OE2 . GLU   A 1 97  ? -1.35658  13.38035  -8.65085  1.000 39.14241 ? 97  GLU   A OE2 1 
ATOM   82   N  N   . ASP   A 1 98  ? -4.52284  8.59296   -12.45941 1.000 24.16670 ? 98  ASP   A N   1 
ATOM   83   C  CA  . ASP   A 1 98  ? -4.84839  7.20427   -12.77799 1.000 24.16665 ? 98  ASP   A CA  1 
ATOM   84   C  C   . ASP   A 1 98  ? -5.00745  6.94933   -14.27109 1.000 21.32761 ? 98  ASP   A C   1 
ATOM   85   O  O   . ASP   A 1 98  ? -5.46073  5.86678   -14.65723 1.000 21.63282 ? 98  ASP   A O   1 
ATOM   86   C  CB  . ASP   A 1 98  ? -6.12544  6.76910   -12.06135 1.000 24.70083 ? 98  ASP   A CB  1 
ATOM   87   C  CG  . ASP   A 1 98  ? -5.98739  6.79335   -10.56396 1.000 24.69779 ? 98  ASP   A CG  1 
ATOM   88   O  OD1 . ASP   A 1 98  ? -4.84923  6.94582   -10.07570 1.000 29.87060 ? 98  ASP   A OD1 1 
ATOM   89   O  OD2 . ASP   A 1 98  ? -7.02025  6.65260   -9.88369  1.000 28.83564 ? 98  ASP   A OD2 1 
ATOM   90   N  N   . VAL   A 1 99  ? -4.62403  7.90332   -15.11727 1.000 19.75531 ? 99  VAL   A N   1 
ATOM   91   C  CA  . VAL   A 1 99  ? -4.98983  7.81959   -16.52162 1.000 18.33874 ? 99  VAL   A CA  1 
ATOM   92   C  C   . VAL   A 1 99  ? -4.36565  6.59665   -17.17851 1.000 18.32958 ? 99  VAL   A C   1 
ATOM   93   O  O   . VAL   A 1 99  ? -4.88823  6.08730   -18.16945 1.000 19.96701 ? 99  VAL   A O   1 
ATOM   94   C  CB  . VAL   A 1 99  ? -4.60463  9.12094   -17.25048 1.000 23.22457 ? 99  VAL   A CB  1 
ATOM   95   C  CG1 . VAL   A 1 99  ? -3.09241  9.23267   -17.39690 1.000 19.72208 ? 99  VAL   A CG1 1 
ATOM   96   C  CG2 . VAL   A 1 99  ? -5.28988  9.17698   -18.61158 1.000 23.24246 ? 99  VAL   A CG2 1 
ATOM   97   N  N   . ASN   A 1 100 ? -3.24771  6.11338   -16.65752 1.000 18.05446 ? 100 ASN   A N   1 
ATOM   98   C  CA  . ASN   A 1 100 ? -2.64464  4.90282   -17.18533 1.000 18.58691 ? 100 ASN   A CA  1 
ATOM   99   C  C   . ASN   A 1 100 ? -3.25532  3.64818   -16.59763 1.000 16.63345 ? 100 ASN   A C   1 
ATOM   100  O  O   . ASN   A 1 100 ? -2.78699  2.55069   -16.90067 1.000 22.30555 ? 100 ASN   A O   1 
ATOM   101  C  CB  . ASN   A 1 100 ? -1.13678  4.90601   -16.92277 1.000 20.68075 ? 100 ASN   A CB  1 
ATOM   102  C  CG  . ASN   A 1 100 ? -0.46485  6.15613   -17.44667 1.000 22.02356 ? 100 ASN   A CG  1 
ATOM   103  O  OD1 . ASN   A 1 100 ? -1.03295  6.86348   -18.26861 1.000 24.20239 ? 100 ASN   A OD1 1 
ATOM   104  N  ND2 . ASN   A 1 100 ? 0.75248   6.43665   -16.97523 1.000 20.72391 ? 100 ASN   A ND2 1 
ATOM   105  N  N   . LYS   A 1 101 ? -4.26726  3.77137   -15.75408 1.000 18.83302 ? 101 LYS   A N   1 
ATOM   106  C  CA  . LYS   A 1 101 ? -4.80660  2.63240   -15.02824 1.000 19.70417 ? 101 LYS   A CA  1 
ATOM   107  C  C   . LYS   A 1 101 ? -6.16294  2.23270   -15.59024 1.000 16.77201 ? 101 LYS   A C   1 
ATOM   108  O  O   . LYS   A 1 101 ? -7.03775  3.07886   -15.79286 1.000 14.82212 ? 101 LYS   A O   1 
ATOM   109  C  CB  . LYS   A 1 101 ? -4.92380  2.93622   -13.52729 1.000 22.51240 ? 101 LYS   A CB  1 
ATOM   110  C  CG  . LYS   A 1 101 ? -3.60499  3.27919   -12.86547 1.000 21.60462 ? 101 LYS   A CG  1 
ATOM   111  C  CD  . LYS   A 1 101 ? -3.66466  3.09232   -11.36498 1.000 28.53756 ? 101 LYS   A CD  1 
ATOM   112  C  CE  . LYS   A 1 101 ? -2.38379  3.56717   -10.68249 1.000 28.16901 ? 101 LYS   A CE  1 
ATOM   113  N  NZ  . LYS   A 1 101 ? -2.49502  3.45192   -9.19145  1.000 37.94300 ? 101 LYS   A NZ  1 
ATOM   114  N  N   . TRP   A 1 102 ? -6.32209  0.94001   -15.83959 1.000 17.82619 ? 102 TRP   A N   1 
ATOM   115  C  CA  . TRP   A 1 102 ? -7.63161  0.37462   -16.11304 1.000 12.20367 ? 102 TRP   A CA  1 
ATOM   116  C  C   . TRP   A 1 102 ? -8.56189  0.66475   -14.94901 1.000 19.60624 ? 102 TRP   A C   1 
ATOM   117  O  O   . TRP   A 1 102 ? -8.21570  0.43638   -13.78668 1.000 24.00584 ? 102 TRP   A O   1 
ATOM   118  C  CB  . TRP   A 1 102 ? -7.48976  -1.12813  -16.32197 1.000 18.99568 ? 102 TRP   A CB  1 
ATOM   119  C  CG  . TRP   A 1 102 ? -8.56561  -1.75702  -17.12949 1.000 18.67111 ? 102 TRP   A CG  1 
ATOM   120  C  CD1 . TRP   A 1 102 ? -9.53176  -2.63159  -16.68930 1.000 10.84196 ? 102 TRP   A CD1 1 
ATOM   121  C  CD2 . TRP   A 1 102 ? -8.77016  -1.59722  -18.53210 1.000 10.52319 ? 102 TRP   A CD2 1 
ATOM   122  N  NE1 . TRP   A 1 102 ? -10.33377 -3.00810  -17.74565 1.000 13.84887 ? 102 TRP   A NE1 1 
ATOM   123  C  CE2 . TRP   A 1 102 ? -9.88107  -2.39173  -18.88719 1.000 11.40165 ? 102 TRP   A CE2 1 
ATOM   124  C  CE3 . TRP   A 1 102 ? -8.12551  -0.84958  -19.52903 1.000 15.76983 ? 102 TRP   A CE3 1 
ATOM   125  C  CZ2 . TRP   A 1 102 ? -10.36762 -2.44727  -20.19700 1.000 11.46343 ? 102 TRP   A CZ2 1 
ATOM   126  C  CZ3 . TRP   A 1 102 ? -8.61543  -0.89724  -20.82216 1.000 7.58205  ? 102 TRP   A CZ3 1 
ATOM   127  C  CH2 . TRP   A 1 102 ? -9.72567  -1.69098  -21.14406 1.000 10.05412 ? 102 TRP   A CH2 1 
ATOM   128  N  N   . GLY   A 1 103 ? -9.73851  1.19100   -15.24402 1.000 22.91361 ? 103 GLY   A N   1 
ATOM   129  C  CA  . GLY   A 1 103 ? -10.66276 1.44223   -14.16656 1.000 22.41391 ? 103 GLY   A CA  1 
ATOM   130  C  C   . GLY   A 1 103 ? -10.50310 2.78272   -13.49714 1.000 26.65503 ? 103 GLY   A C   1 
ATOM   131  O  O   . GLY   A 1 103 ? -11.03212 2.97167   -12.39188 1.000 31.47637 ? 103 GLY   A O   1 
ATOM   132  N  N   . LEU   A 1 104 ? -9.74532  3.69507   -14.10005 1.000 17.02434 ? 104 LEU   A N   1 
ATOM   133  C  CA  . LEU   A 1 104 ? -9.92540  5.11701   -13.86807 1.000 17.43976 ? 104 LEU   A CA  1 
ATOM   134  C  C   . LEU   A 1 104 ? -11.38504 5.40464   -13.55302 1.000 21.33515 ? 104 LEU   A C   1 
ATOM   135  O  O   . LEU   A 1 104 ? -12.26385 4.88317   -14.24365 1.000 20.03748 ? 104 LEU   A O   1 
ATOM   136  C  CB  . LEU   A 1 104 ? -9.50228  5.89798   -15.10658 1.000 13.29673 ? 104 LEU   A CB  1 
ATOM   137  C  CG  . LEU   A 1 104 ? -9.79992  7.38417   -15.03054 1.000 17.48307 ? 104 LEU   A CG  1 
ATOM   138  C  CD1 . LEU   A 1 104 ? -8.63224  8.03476   -14.34590 1.000 17.56475 ? 104 LEU   A CD1 1 
ATOM   139  C  CD2 . LEU   A 1 104 ? -10.03967 7.99377   -16.42816 1.000 12.82962 ? 104 LEU   A CD2 1 
ATOM   140  N  N   . HIS   A 1 105 ? -11.65894 6.20889   -12.51373 1.000 21.31865 ? 105 HIS   A N   1 
ATOM   141  C  CA  . HIS   A 1 105 ? -13.02458 6.62585   -12.17632 1.000 20.19122 ? 105 HIS   A CA  1 
ATOM   142  C  C   . HIS   A 1 105 ? -13.47064 7.70241   -13.16612 1.000 19.70724 ? 105 HIS   A C   1 
ATOM   143  O  O   . HIS   A 1 105 ? -13.47942 8.90406   -12.87505 1.000 18.12003 ? 105 HIS   A O   1 
ATOM   144  C  CB  . HIS   A 1 105 ? -13.11692 7.14018   -10.73885 1.000 25.18616 ? 105 HIS   A CB  1 
ATOM   145  C  CG  . HIS   A 1 105 ? -12.38843 6.29978   -9.73488  1.000 37.94746 ? 105 HIS   A CG  1 
ATOM   146  N  ND1 . HIS   A 1 105 ? -11.58754 6.84410   -8.75106  1.000 42.61828 ? 105 HIS   A ND1 1 
ATOM   147  C  CD2 . HIS   A 1 105 ? -12.33795 4.95717   -9.55840  1.000 40.91699 ? 105 HIS   A CD2 1 
ATOM   148  C  CE1 . HIS   A 1 105 ? -11.07372 5.87325   -8.01589  1.000 34.87765 ? 105 HIS   A CE1 1 
ATOM   149  N  NE2 . HIS   A 1 105 ? -11.51507 4.71887   -8.48323  1.000 38.24829 ? 105 HIS   A NE2 1 
ATOM   150  N  N   . VAL   A 1 106 ? -13.87279 7.25831   -14.36170 1.000 16.66107 ? 106 VAL   A N   1 
ATOM   151  C  CA  . VAL   A 1 106 ? -14.19950 8.23291   -15.40213 1.000 15.13564 ? 106 VAL   A CA  1 
ATOM   152  C  C   . VAL   A 1 106 ? -15.40442 9.08995   -14.99651 1.000 14.56204 ? 106 VAL   A C   1 
ATOM   153  O  O   . VAL   A 1 106 ? -15.52619 10.24081  -15.42923 1.000 14.52328 ? 106 VAL   A O   1 
ATOM   154  C  CB  . VAL   A 1 106 ? -14.41476 7.51890   -16.74853 1.000 16.14239 ? 106 VAL   A CB  1 
ATOM   155  C  CG1 . VAL   A 1 106 ? -15.66864 6.61424   -16.70554 1.000 14.47489 ? 106 VAL   A CG1 1 
ATOM   156  C  CG2 . VAL   A 1 106 ? -14.50724 8.52254   -17.88274 1.000 11.36290 ? 106 VAL   A CG2 1 
ATOM   157  N  N   . PHE   A 1 107 ? -16.29567 8.56374   -14.14980 1.000 18.54577 ? 107 PHE   A N   1 
ATOM   158  C  CA  . PHE   A 1 107 ? -17.46473 9.33524   -13.73479 1.000 15.60133 ? 107 PHE   A CA  1 
ATOM   159  C  C   . PHE   A 1 107 ? -17.09094 10.43129  -12.73966 1.000 17.34172 ? 107 PHE   A C   1 
ATOM   160  O  O   . PHE   A 1 107 ? -17.65127 11.53349  -12.78593 1.000 17.14548 ? 107 PHE   A O   1 
ATOM   161  C  CB  . PHE   A 1 107 ? -18.53222 8.41009   -13.14055 1.000 16.17023 ? 107 PHE   A CB  1 
ATOM   162  C  CG  . PHE   A 1 107 ? -19.17146 7.49950   -14.15032 1.000 16.75691 ? 107 PHE   A CG  1 
ATOM   163  C  CD1 . PHE   A 1 107 ? -20.15512 7.97321   -15.00404 1.000 12.83258 ? 107 PHE   A CD1 1 
ATOM   164  C  CD2 . PHE   A 1 107 ? -18.77864 6.17340   -14.25475 1.000 14.83845 ? 107 PHE   A CD2 1 
ATOM   165  C  CE1 . PHE   A 1 107 ? -20.74377 7.13854   -15.92995 1.000 15.00255 ? 107 PHE   A CE1 1 
ATOM   166  C  CE2 . PHE   A 1 107 ? -19.35181 5.33114   -15.19107 1.000 14.05992 ? 107 PHE   A CE2 1 
ATOM   167  C  CZ  . PHE   A 1 107 ? -20.33737 5.81532   -16.03271 1.000 13.48495 ? 107 PHE   A CZ  1 
ATOM   168  N  N   . ARG   A 1 108 ? -16.16649 10.14545  -11.81822 1.000 17.00633 ? 108 ARG   A N   1 
ATOM   169  C  CA  . ARG   A 1 108 ? -15.70152 11.19056  -10.91288 1.000 25.39182 ? 108 ARG   A CA  1 
ATOM   170  C  C   . ARG   A 1 108 ? -15.05550 12.31846  -11.69218 1.000 20.50319 ? 108 ARG   A C   1 
ATOM   171  O  O   . ARG   A 1 108 ? -15.33818 13.50301  -11.45375 1.000 22.85708 ? 108 ARG   A O   1 
ATOM   172  C  CB  . ARG   A 1 108 ? -14.70924 10.62391  -9.90454  1.000 28.80796 ? 108 ARG   A CB  1 
ATOM   173  C  CG  . ARG   A 1 108 ? -15.34664 9.95681   -8.74404  1.000 35.99328 ? 108 ARG   A CG  1 
ATOM   174  C  CD  . ARG   A 1 108 ? -14.31567 9.70250   -7.65901  1.000 40.40582 ? 108 ARG   A CD  1 
ATOM   175  N  NE  . ARG   A 1 108 ? -14.76046 8.62035   -6.79196  1.000 38.70303 ? 108 ARG   A NE  1 
ATOM   176  C  CZ  . ARG   A 1 108 ? -13.94937 7.78835   -6.15854  1.000 39.63785 ? 108 ARG   A CZ  1 
ATOM   177  N  NH1 . ARG   A 1 108 ? -12.62808 7.90708   -6.28358  1.000 29.19754 ? 108 ARG   A NH1 1 
ATOM   178  N  NH2 . ARG   A 1 108 ? -14.46838 6.82870   -5.40389  1.000 32.53501 ? 108 ARG   A NH2 1 
ATOM   179  N  N   . ILE   A 1 109 ? -14.20978 11.95660  -12.65685 1.000 17.69502 ? 109 ILE   A N   1 
ATOM   180  C  CA  . ILE   A 1 109 ? -13.54038 12.94202  -13.49317 1.000 18.97129 ? 109 ILE   A CA  1 
ATOM   181  C  C   . ILE   A 1 109 ? -14.54669 13.80224  -14.24465 1.000 18.91911 ? 109 ILE   A C   1 
ATOM   182  O  O   . ILE   A 1 109 ? -14.32406 15.00701  -14.43963 1.000 18.03872 ? 109 ILE   A O   1 
ATOM   183  C  CB  . ILE   A 1 109 ? -12.55762 12.21100  -14.42466 1.000 18.16990 ? 109 ILE   A CB  1 
ATOM   184  C  CG1 . ILE   A 1 109 ? -11.24544 11.96436  -13.66716 1.000 17.72224 ? 109 ILE   A CG1 1 
ATOM   185  C  CG2 . ILE   A 1 109 ? -12.32416 12.98436  -15.69623 1.000 16.60634 ? 109 ILE   A CG2 1 
ATOM   186  C  CD1 . ILE   A 1 109 ? -10.27488 11.14822  -14.40477 1.000 17.68435 ? 109 ILE   A CD1 1 
ATOM   187  N  N   . ALA   A 1 110 ? -15.67769 13.21937  -14.64983 1.000 17.45050 ? 110 ALA   A N   1 
ATOM   188  C  CA  . ALA   A 1 110 ? -16.71640 14.00826  -15.30805 1.000 15.94897 ? 110 ALA   A CA  1 
ATOM   189  C  C   . ALA   A 1 110 ? -17.30117 15.04037  -14.35199 1.000 20.67357 ? 110 ALA   A C   1 
ATOM   190  O  O   . ALA   A 1 110 ? -17.47975 16.20856  -14.71539 1.000 19.24233 ? 110 ALA   A O   1 
ATOM   191  C  CB  . ALA   A 1 110 ? -17.80514 13.08036  -15.84107 1.000 14.44641 ? 110 ALA   A CB  1 
ATOM   192  N  N   . GLU   A 1 111 ? -17.60274 14.61717  -13.11901 1.000 21.88206 ? 111 GLU   A N   1 
ATOM   193  C  CA  . GLU   A 1 111 ? -18.00484 15.54427  -12.06088 1.000 23.02320 ? 111 GLU   A CA  1 
ATOM   194  C  C   . GLU   A 1 111 ? -16.93451 16.59936  -11.82449 1.000 19.38593 ? 111 GLU   A C   1 
ATOM   195  O  O   . GLU   A 1 111 ? -17.18456 17.80308  -11.94801 1.000 20.60981 ? 111 GLU   A O   1 
ATOM   196  C  CB  . GLU   A 1 111 ? -18.25213 14.78014  -10.74990 1.000 27.58789 ? 111 GLU   A CB  1 
ATOM   197  C  CG  . GLU   A 1 111 ? -19.50816 13.93999  -10.65546 1.000 31.80825 ? 111 GLU   A CG  1 
ATOM   198  C  CD  . GLU   A 1 111 ? -19.53247 13.08241  -9.37670  1.000 45.43036 ? 111 GLU   A CD  1 
ATOM   199  O  OE1 . GLU   A 1 111 ? -18.46084 12.89901  -8.74426  1.000 39.28382 ? 111 GLU   A OE1 1 
ATOM   200  O  OE2 . GLU   A 1 111 ? -20.62624 12.60151  -9.00076  1.000 47.43473 ? 111 GLU   A OE2 1 
ATOM   201  N  N   . LEU   A 1 112 ? -15.72499 16.14748  -11.46961 1.000 19.52426 ? 112 LEU   A N   1 
ATOM   202  C  CA  . LEU   A 1 112 ? -14.66069 17.03723  -11.01930 1.000 21.07779 ? 112 LEU   A CA  1 
ATOM   203  C  C   . LEU   A 1 112 ? -14.20119 18.00861  -12.09389 1.000 21.28058 ? 112 LEU   A C   1 
ATOM   204  O  O   . LEU   A 1 112 ? -13.64250 19.05862  -11.75747 1.000 24.01452 ? 112 LEU   A O   1 
ATOM   205  C  CB  . LEU   A 1 112 ? -13.46148 16.22274  -10.53353 1.000 15.47099 ? 112 LEU   A CB  1 
ATOM   206  C  CG  . LEU   A 1 112 ? -13.65123 15.46733  -9.22663  1.000 21.67623 ? 112 LEU   A CG  1 
ATOM   207  C  CD1 . LEU   A 1 112 ? -12.52640 14.47876  -9.05371  1.000 20.35450 ? 112 LEU   A CD1 1 
ATOM   208  C  CD2 . LEU   A 1 112 ? -13.68315 16.45116  -8.07413  1.000 26.63243 ? 112 LEU   A CD2 1 
ATOM   209  N  N   . SER   A 1 113 ? -14.39169 17.68259  -13.37034 1.000 18.04541 ? 113 SER   A N   1 
ATOM   210  C  CA  . SER   A 1 113 ? -14.02687 18.57896  -14.46030 1.000 17.64457 ? 113 SER   A CA  1 
ATOM   211  C  C   . SER   A 1 113 ? -15.20841 19.39254  -14.98328 1.000 19.43106 ? 113 SER   A C   1 
ATOM   212  O  O   . SER   A 1 113 ? -15.06510 20.10479  -15.98749 1.000 21.15835 ? 113 SER   A O   1 
ATOM   213  C  CB  . SER   A 1 113 ? -13.39399 17.78342  -15.61171 1.000 17.65576 ? 113 SER   A CB  1 
ATOM   214  O  OG  . SER   A 1 113 ? -14.32405 16.87406  -16.18584 1.000 14.28230 ? 113 SER   A OG  1 
ATOM   215  N  N   . GLY   A 1 114 ? -16.37247 19.29619  -14.35116 1.000 17.88369 ? 114 GLY   A N   1 
ATOM   216  C  CA  . GLY   A 1 114 ? -17.50355 20.07330  -14.82983 1.000 20.37821 ? 114 GLY   A CA  1 
ATOM   217  C  C   . GLY   A 1 114 ? -18.01265 19.61081  -16.17678 1.000 21.12388 ? 114 GLY   A C   1 
ATOM   218  O  O   . GLY   A 1 114 ? -17.99019 20.36464  -17.15490 1.000 22.03754 ? 114 GLY   A O   1 
ATOM   219  N  N   . ASN   A 1 115 ? -18.47129 18.35896  -16.22564 1.000 20.62217 ? 115 ASN   A N   1 
ATOM   220  C  CA  . ASN   A 1 115 ? -18.88774 17.67476  -17.44785 1.000 20.79841 ? 115 ASN   A CA  1 
ATOM   221  C  C   . ASN   A 1 115 ? -17.99459 17.93365  -18.64886 1.000 18.20281 ? 115 ASN   A C   1 
ATOM   222  O  O   . ASN   A 1 115 ? -18.49485 18.11321  -19.76523 1.000 19.91551 ? 115 ASN   A O   1 
ATOM   223  C  CB  . ASN   A 1 115 ? -20.31801 18.03056  -17.84722 1.000 19.41141 ? 115 ASN   A CB  1 
ATOM   224  C  CG  . ASN   A 1 115 ? -20.98908 16.88432  -18.58676 1.000 23.56722 ? 115 ASN   A CG  1 
ATOM   225  O  OD1 . ASN   A 1 115 ? -20.78981 15.71071  -18.23400 1.000 22.97178 ? 115 ASN   A OD1 1 
ATOM   226  N  ND2 . ASN   A 1 115 ? -21.76189 17.20129  -19.61421 1.000 21.23531 ? 115 ASN   A ND2 1 
ATOM   227  N  N   . ARG   A 1 116 ? -16.68119 17.92652  -18.43937 1.000 16.57678 ? 116 ARG   A N   1 
ATOM   228  C  CA  . ARG   A 1 116 ? -15.71967 17.88819  -19.54357 1.000 19.42185 ? 116 ARG   A CA  1 
ATOM   229  C  C   . ARG   A 1 116 ? -14.75307 16.70792  -19.40985 1.000 13.99011 ? 116 ARG   A C   1 
ATOM   230  O  O   . ARG   A 1 116 ? -13.54115 16.87561  -19.52004 1.000 14.92682 ? 116 ARG   A O   1 
ATOM   231  C  CB  . ARG   A 1 116 ? -14.94679 19.20645  -19.61258 1.000 18.96485 ? 116 ARG   A CB  1 
ATOM   232  C  CG  . ARG   A 1 116 ? -15.81301 20.40860  -19.88227 1.000 21.22352 ? 116 ARG   A CG  1 
ATOM   233  C  CD  . ARG   A 1 116 ? -16.59247 20.24103  -21.18552 1.000 26.20618 ? 116 ARG   A CD  1 
ATOM   234  N  NE  . ARG   A 1 116 ? -16.95002 21.53429  -21.76795 1.000 33.04553 ? 116 ARG   A NE  1 
ATOM   235  C  CZ  . ARG   A 1 116 ? -17.28713 21.73138  -23.04359 1.000 29.26805 ? 116 ARG   A CZ  1 
ATOM   236  N  NH1 . ARG   A 1 116 ? -17.31421 20.71785  -23.89629 1.000 21.48400 ? 116 ARG   A NH1 1 
ATOM   237  N  NH2 . ARG   A 1 116 ? -17.60004 22.95654  -23.46588 1.000 29.37261 ? 116 ARG   A NH2 1 
ATOM   238  N  N   . PRO   A 1 117 ? -15.25450 15.48668  -19.17275 1.000 16.31412 ? 117 PRO   A N   1 
ATOM   239  C  CA  . PRO   A 1 117 ? -14.31446 14.35179  -19.08180 1.000 12.66212 ? 117 PRO   A CA  1 
ATOM   240  C  C   . PRO   A 1 117 ? -13.50769 14.13522  -20.34463 1.000 11.90078 ? 117 PRO   A C   1 
ATOM   241  O  O   . PRO   A 1 117 ? -12.30034 13.84459  -20.26672 1.000 10.69551 ? 117 PRO   A O   1 
ATOM   242  C  CB  . PRO   A 1 117 ? -15.23075 13.15400  -18.79025 1.000 14.37545 ? 117 PRO   A CB  1 
ATOM   243  C  CG  . PRO   A 1 117 ? -16.57180 13.56264  -19.30306 1.000 13.04975 ? 117 PRO   A CG  1 
ATOM   244  C  CD  . PRO   A 1 117 ? -16.64991 15.03539  -19.00298 1.000 15.55924 ? 117 PRO   A CD  1 
ATOM   245  N  N   . LEU   A 1 118 ? -14.14965 14.24704  -21.51379 1.000 12.95034 ? 118 LEU   A N   1 
ATOM   246  C  CA  . LEU   A 1 118 ? -13.44538 13.97075  -22.76361 1.000 8.90074  ? 118 LEU   A CA  1 
ATOM   247  C  C   . LEU   A 1 118 ? -12.31874 14.97552  -22.97961 1.000 10.61571 ? 118 LEU   A C   1 
ATOM   248  O  O   . LEU   A 1 118 ? -11.19309 14.59700  -23.33111 1.000 11.85288 ? 118 LEU   A O   1 
ATOM   249  C  CB  . LEU   A 1 118 ? -14.42588 13.98550  -23.94134 1.000 7.61343  ? 118 LEU   A CB  1 
ATOM   250  C  CG  . LEU   A 1 118 ? -13.70901 13.74213  -25.27549 1.000 10.25700 ? 118 LEU   A CG  1 
ATOM   251  C  CD1 . LEU   A 1 118 ? -13.02159 12.37376  -25.25097 1.000 9.03931  ? 118 LEU   A CD1 1 
ATOM   252  C  CD2 . LEU   A 1 118 ? -14.60765 13.91238  -26.49672 1.000 9.48439  ? 118 LEU   A CD2 1 
ATOM   253  N  N   . THR   A 1 119 ? -12.58256 16.25827  -22.70698 1.000 14.15409 ? 119 THR   A N   1 
ATOM   254  C  CA  . THR   A 1 119 ? -11.55231 17.27364  -22.91250 1.000 12.96769 ? 119 THR   A CA  1 
ATOM   255  C  C   . THR   A 1 119 ? -10.34473 17.06208  -21.98789 1.000 16.34777 ? 119 THR   A C   1 
ATOM   256  O  O   . THR   A 1 119 ? -9.19475  17.13886  -22.44504 1.000 16.31851 ? 119 THR   A O   1 
ATOM   257  C  CB  . THR   A 1 119 ? -12.16814 18.66374  -22.75506 1.000 15.68484 ? 119 THR   A CB  1 
ATOM   258  O  OG1 . THR   A 1 119 ? -13.09707 18.88188  -23.82837 1.000 12.51695 ? 119 THR   A OG1 1 
ATOM   259  C  CG2 . THR   A 1 119 ? -11.09059 19.77069  -22.79042 1.000 16.70818 ? 119 THR   A CG2 1 
ATOM   260  N  N   . VAL   A 1 120 ? -10.56607 16.74979  -20.70195 1.000 13.40568 ? 120 VAL   A N   1 
ATOM   261  C  CA  . VAL   A 1 120 ? -9.40263  16.70116  -19.80757 1.000 10.06573 ? 120 VAL   A CA  1 
ATOM   262  C  C   . VAL   A 1 120 ? -8.67493  15.37609  -19.90969 1.000 13.14871 ? 120 VAL   A C   1 
ATOM   263  O  O   . VAL   A 1 120 ? -7.45736  15.31579  -19.69544 1.000 14.65671 ? 120 VAL   A O   1 
ATOM   264  C  CB  . VAL   A 1 120 ? -9.76905  16.99892  -18.32990 1.000 16.67555 ? 120 VAL   A CB  1 
ATOM   265  C  CG1 . VAL   A 1 120 ? -10.44836 18.39231  -18.16932 1.000 15.77945 ? 120 VAL   A CG1 1 
ATOM   266  C  CG2 . VAL   A 1 120 ? -10.61196 15.86381  -17.70351 1.000 16.96412 ? 120 VAL   A CG2 1 
ATOM   267  N  N   . ILE   A 1 121 ? -9.37950  14.28751  -20.20714 1.000 12.11932 ? 121 ILE   A N   1 
ATOM   268  C  CA  . ILE   A 1 121 ? -8.67290  13.01847  -20.34643 1.000 13.24974 ? 121 ILE   A CA  1 
ATOM   269  C  C   . ILE   A 1 121 ? -7.85564  13.01803  -21.62849 1.000 9.99466  ? 121 ILE   A C   1 
ATOM   270  O  O   . ILE   A 1 121 ? -6.70761  12.54979  -21.65017 1.000 19.04082 ? 121 ILE   A O   1 
ATOM   271  C  CB  . ILE   A 1 121 ? -9.66414  11.83994  -20.26665 1.000 11.49199 ? 121 ILE   A CB  1 
ATOM   272  C  CG1 . ILE   A 1 121 ? -9.93014  11.49720  -18.80253 1.000 12.05463 ? 121 ILE   A CG1 1 
ATOM   273  C  CG2 . ILE   A 1 121 ? -9.17183  10.61609  -21.07497 1.000 11.33106 ? 121 ILE   A CG2 1 
ATOM   274  C  CD1 . ILE   A 1 121 ? -11.22222 10.73681  -18.58633 1.000 13.97350 ? 121 ILE   A CD1 1 
ATOM   275  N  N   . MET   A 1 122 ? -8.40959  13.56374  -22.70704 1.000 12.78114 ? 122 MET   A N   1 
ATOM   276  C  CA  . MET   A 1 122 ? -7.62980  13.71926  -23.94096 1.000 12.66103 ? 122 MET   A CA  1 
ATOM   277  C  C   . MET   A 1 122 ? -6.41884  14.61839  -23.71999 1.000 12.70688 ? 122 MET   A C   1 
ATOM   278  O  O   . MET   A 1 122 ? -5.29104  14.27003  -24.08639 1.000 13.99175 ? 122 MET   A O   1 
ATOM   279  C  CB  . MET   A 1 122 ? -8.51511  14.28656  -25.04317 1.000 11.42022 ? 122 MET   A CB  1 
ATOM   280  C  CG  . MET   A 1 122 ? -9.43125  13.25467  -25.71173 1.000 13.86362 ? 122 MET   A CG  1 
ATOM   281  S  SD  . MET   A 1 122 ? -8.56163  12.15407  -26.86123 1.000 12.60826 ? 122 MET   A SD  1 
ATOM   282  C  CE  . MET   A 1 122 ? -8.45168  13.18695  -28.31070 1.000 7.19101  ? 122 MET   A CE  1 
ATOM   283  N  N   . HIS   A 1 123 ? -6.63986  15.79173  -23.12861 1.000 12.32011 ? 123 HIS   A N   1 
ATOM   284  C  CA  . HIS   A 1 123 ? -5.53152  16.68542  -22.80936 1.000 15.25197 ? 123 HIS   A CA  1 
ATOM   285  C  C   . HIS   A 1 123 ? -4.44527  15.94682  -22.03531 1.000 13.95786 ? 123 HIS   A C   1 
ATOM   286  O  O   . HIS   A 1 123 ? -3.27789  15.92592  -22.44071 1.000 16.13271 ? 123 HIS   A O   1 
ATOM   287  C  CB  . HIS   A 1 123 ? -6.06204  17.88553  -22.01443 1.000 17.89358 ? 123 HIS   A CB  1 
ATOM   288  C  CG  . HIS   A 1 123 ? -5.06216  18.98552  -21.83617 1.000 24.55725 ? 123 HIS   A CG  1 
ATOM   289  N  ND1 . HIS   A 1 123 ? -4.28242  19.45606  -22.87110 1.000 27.56296 ? 123 HIS   A ND1 1 
ATOM   290  C  CD2 . HIS   A 1 123 ? -4.70931  19.70337  -20.74313 1.000 31.16427 ? 123 HIS   A CD2 1 
ATOM   291  C  CE1 . HIS   A 1 123 ? -3.49780  20.42069  -22.42673 1.000 29.88316 ? 123 HIS   A CE1 1 
ATOM   292  N  NE2 . HIS   A 1 123 ? -3.73978  20.59417  -21.13943 1.000 35.04439 ? 123 HIS   A NE2 1 
ATOM   293  N  N   . THR   A 1 124 ? -4.83701  15.29054  -20.93745 1.000 16.33438 ? 124 THR   A N   1 
ATOM   294  C  CA  . THR   A 1 124 ? -3.89885  14.54176  -20.10504 1.000 15.27360 ? 124 THR   A CA  1 
ATOM   295  C  C   . THR   A 1 124 ? -3.13427  13.52081  -20.92549 1.000 14.53472 ? 124 THR   A C   1 
ATOM   296  O  O   . THR   A 1 124 ? -1.89884  13.44053  -20.86084 1.000 19.94586 ? 124 THR   A O   1 
ATOM   297  C  CB  . THR   A 1 124 ? -4.66534  13.85924  -18.97228 1.000 16.72998 ? 124 THR   A CB  1 
ATOM   298  O  OG1 . THR   A 1 124 ? -5.39241  14.85359  -18.24790 1.000 14.13050 ? 124 THR   A OG1 1 
ATOM   299  C  CG2 . THR   A 1 124 ? -3.72890  13.09744  -18.01327 1.000 16.37577 ? 124 THR   A CG2 1 
ATOM   300  N  N   . ILE   A 1 125 ? -3.85394  12.75935  -21.74308 1.000 18.06853 ? 125 ILE   A N   1 
ATOM   301  C  CA  . ILE   A 1 125 ? -3.20575  11.72448  -22.53251 1.000 16.36956 ? 125 ILE   A CA  1 
ATOM   302  C  C   . ILE   A 1 125 ? -2.26755  12.33737  -23.55977 1.000 15.38462 ? 125 ILE   A C   1 
ATOM   303  O  O   . ILE   A 1 125 ? -1.14882  11.84804  -23.75130 1.000 19.67664 ? 125 ILE   A O   1 
ATOM   304  C  CB  . ILE   A 1 125 ? -4.25683  10.80398  -23.17917 1.000 17.42612 ? 125 ILE   A CB  1 
ATOM   305  C  CG1 . ILE   A 1 125 ? -4.73776  9.77840   -22.14590 1.000 18.43924 ? 125 ILE   A CG1 1 
ATOM   306  C  CG2 . ILE   A 1 125 ? -3.66288  10.09662  -24.37293 1.000 11.52161 ? 125 ILE   A CG2 1 
ATOM   307  C  CD1 . ILE   A 1 125 ? -6.14743  9.26182   -22.34688 1.000 13.84822 ? 125 ILE   A CD1 1 
ATOM   308  N  N   . PHE   A 1 126 ? -2.67880  13.42897  -24.21904 1.000 12.45632 ? 126 PHE   A N   1 
ATOM   309  C  CA  . PHE   A 1 126 ? -1.77128  14.04817  -25.18831 1.000 15.14933 ? 126 PHE   A CA  1 
ATOM   310  C  C   . PHE   A 1 126 ? -0.47607  14.52794  -24.52876 1.000 17.03710 ? 126 PHE   A C   1 
ATOM   311  O  O   . PHE   A 1 126 ? 0.61274   14.35850  -25.09928 1.000 17.93221 ? 126 PHE   A O   1 
ATOM   312  C  CB  . PHE   A 1 126 ? -2.46391  15.19320  -25.92689 1.000 11.86131 ? 126 PHE   A CB  1 
ATOM   313  C  CG  . PHE   A 1 126 ? -3.25003  14.73927  -27.13848 1.000 11.43804 ? 126 PHE   A CG  1 
ATOM   314  C  CD1 . PHE   A 1 126 ? -4.21812  13.74286  -27.02321 1.000 8.55852  ? 126 PHE   A CD1 1 
ATOM   315  C  CD2 . PHE   A 1 126 ? -3.02411  15.30234  -28.38087 1.000 8.17375  ? 126 PHE   A CD2 1 
ATOM   316  C  CE1 . PHE   A 1 126 ? -4.96013  13.32810  -28.14636 1.000 7.88275  ? 126 PHE   A CE1 1 
ATOM   317  C  CE2 . PHE   A 1 126 ? -3.74901  14.90518  -29.49567 1.000 8.18432  ? 126 PHE   A CE2 1 
ATOM   318  C  CZ  . PHE   A 1 126 ? -4.73020  13.91285  -29.37377 1.000 8.67613  ? 126 PHE   A CZ  1 
ATOM   319  N  N   . GLN   A 1 127 ? -0.56568  15.11871  -23.32566 1.000 18.06983 ? 127 GLN   A N   1 
ATOM   320  C  CA  . GLN   A 1 127 ? 0.65304   15.49226  -22.60549 1.000 16.42479 ? 127 GLN   A CA  1 
ATOM   321  C  C   . GLN   A 1 127 ? 1.43577   14.25288  -22.20367 1.000 19.89972 ? 127 GLN   A C   1 
ATOM   322  O  O   . GLN   A 1 127 ? 2.65975   14.19851  -22.36690 1.000 18.46686 ? 127 GLN   A O   1 
ATOM   323  C  CB  . GLN   A 1 127 ? 0.33285   16.32146  -21.35864 1.000 20.06912 ? 127 GLN   A CB  1 
ATOM   324  C  CG  . GLN   A 1 127 ? -0.71729  17.39562  -21.53493 1.000 27.96419 ? 127 GLN   A CG  1 
ATOM   325  C  CD  . GLN   A 1 127 ? -0.13693  18.79911  -21.49124 1.000 40.35458 ? 127 GLN   A CD  1 
ATOM   326  O  OE1 . GLN   A 1 127 ? 1.02450   19.02400  -21.86406 1.000 36.66309 ? 127 GLN   A OE1 1 
ATOM   327  N  NE2 . GLN   A 1 127 ? -0.94241  19.75323  -21.02845 1.000 32.70405 ? 127 GLN   A NE2 1 
ATOM   328  N  N   . GLU   A 1 128 ? 0.73694   13.23104  -21.71699 1.000 20.00141 ? 128 GLU   A N   1 
ATOM   329  C  CA  . GLU   A 1 128 ? 1.41799   12.03136  -21.24154 1.000 20.55694 ? 128 GLU   A CA  1 
ATOM   330  C  C   . GLU   A 1 128 ? 2.19908   11.34464  -22.35895 1.000 21.00547 ? 128 GLU   A C   1 
ATOM   331  O  O   . GLU   A 1 128 ? 3.30216   10.84107  -22.12642 1.000 25.37768 ? 128 GLU   A O   1 
ATOM   332  C  CB  . GLU   A 1 128 ? 0.40290   11.06953  -20.61270 1.000 20.64543 ? 128 GLU   A CB  1 
ATOM   333  C  CG  . GLU   A 1 128 ? 1.03537   9.79708   -20.05090 1.000 29.35799 ? 128 GLU   A CG  1 
ATOM   334  C  CD  . GLU   A 1 128 ? 1.74289   10.02930  -18.73046 1.000 28.32679 ? 128 GLU   A CD  1 
ATOM   335  O  OE1 . GLU   A 1 128 ? 2.38670   9.08275   -18.23074 1.000 43.68723 ? 128 GLU   A OE1 1 
ATOM   336  O  OE2 . GLU   A 1 128 ? 1.64859   11.15321  -18.18574 1.000 39.65052 ? 128 GLU   A OE2 1 
ATOM   337  N  N   . ARG   A 1 129 ? 1.65898   11.32174  -23.57951 1.000 15.37718 ? 129 ARG   A N   1 
ATOM   338  C  CA  . ARG   A 1 129 ? 2.35105   10.70764  -24.70812 1.000 18.37237 ? 129 ARG   A CA  1 
ATOM   339  C  C   . ARG   A 1 129 ? 3.18731   11.71035  -25.49881 1.000 16.65273 ? 129 ARG   A C   1 
ATOM   340  O  O   . ARG   A 1 129 ? 3.67909   11.38193  -26.58781 1.000 14.91028 ? 129 ARG   A O   1 
ATOM   341  C  CB  . ARG   A 1 129 ? 1.34427   10.00270  -25.63301 1.000 12.73351 ? 129 ARG   A CB  1 
ATOM   342  C  CG  . ARG   A 1 129 ? 0.52518   8.91499   -24.93279 1.000 16.38525 ? 129 ARG   A CG  1 
ATOM   343  C  CD  . ARG   A 1 129 ? -0.27011  8.04631   -25.93518 1.000 16.25943 ? 129 ARG   A CD  1 
ATOM   344  N  NE  . ARG   A 1 129 ? -0.74854  6.79921   -25.33822 1.000 15.77169 ? 129 ARG   A NE  1 
ATOM   345  C  CZ  . ARG   A 1 129 ? -0.01930  5.69294   -25.25608 1.000 23.34079 ? 129 ARG   A CZ  1 
ATOM   346  N  NH1 . ARG   A 1 129 ? 1.22396   5.68015   -25.73570 1.000 25.82605 ? 129 ARG   A NH1 1 
ATOM   347  N  NH2 . ARG   A 1 129 ? -0.52033  4.59992   -24.69592 1.000 19.30037 ? 129 ARG   A NH2 1 
ATOM   348  N  N   . ASP   A 1 130 ? 3.34877   12.91769  -24.97242 1.000 20.61295 ? 130 ASP   A N   1 
ATOM   349  C  CA  . ASP   A 1 130 ? 4.12343   13.97085  -25.61463 1.000 22.51960 ? 130 ASP   A CA  1 
ATOM   350  C  C   . ASP   A 1 130 ? 3.69644   14.18920  -27.06316 1.000 23.49799 ? 130 ASP   A C   1 
ATOM   351  O  O   . ASP   A 1 130 ? 4.52851   14.39634  -27.94807 1.000 20.69145 ? 130 ASP   A O   1 
ATOM   352  C  CB  . ASP   A 1 130 ? 5.62050   13.68374  -25.52563 1.000 30.02690 ? 130 ASP   A CB  1 
ATOM   353  C  CG  . ASP   A 1 130 ? 6.43854   14.96014  -25.44384 1.000 29.26943 ? 130 ASP   A CG  1 
ATOM   354  O  OD1 . ASP   A 1 130 ? 5.81784   16.01803  -25.23840 1.000 23.81309 ? 130 ASP   A OD1 1 
ATOM   355  O  OD2 . ASP   A 1 130 ? 7.68228   14.91215  -25.57553 1.000 34.87657 ? 130 ASP   A OD2 1 
ATOM   356  N  N   . LEU   A 1 131 ? 2.37379   14.17759  -27.29893 1.000 23.88435 ? 131 LEU   A N   1 
ATOM   357  C  CA  . LEU   A 1 131 ? 1.83655   14.31242  -28.65207 1.000 16.80674 ? 131 LEU   A CA  1 
ATOM   358  C  C   . LEU   A 1 131 ? 1.73756   15.76514  -29.09741 1.000 18.49772 ? 131 LEU   A C   1 
ATOM   359  O  O   . LEU   A 1 131 ? 1.84064   16.04219  -30.29344 1.000 17.17167 ? 131 LEU   A O   1 
ATOM   360  C  CB  . LEU   A 1 131 ? 0.44686   13.66403  -28.75481 1.000 12.51432 ? 131 LEU   A CB  1 
ATOM   361  C  CG  . LEU   A 1 131 ? 0.33100   12.14669  -28.65962 1.000 15.87108 ? 131 LEU   A CG  1 
ATOM   362  C  CD1 . LEU   A 1 131 ? -1.13952  11.67922  -28.40332 1.000 8.17561  ? 131 LEU   A CD1 1 
ATOM   363  C  CD2 . LEU   A 1 131 ? 0.89831   11.54445  -29.94246 1.000 16.31897 ? 131 LEU   A CD2 1 
ATOM   364  N  N   . LEU   A 1 132 ? 1.49054   16.69719  -28.17351 1.000 24.12704 ? 132 LEU   A N   1 
ATOM   365  C  CA  . LEU   A 1 132 ? 1.50696   18.11108  -28.53714 1.000 22.67069 ? 132 LEU   A CA  1 
ATOM   366  C  C   . LEU   A 1 132 ? 2.82606   18.50328  -29.20193 1.000 23.69789 ? 132 LEU   A C   1 
ATOM   367  O  O   . LEU   A 1 132 ? 2.83449   19.18296  -30.23457 1.000 25.21217 ? 132 LEU   A O   1 
ATOM   368  C  CB  . LEU   A 1 132 ? 1.26821   18.97402  -27.30621 1.000 28.14067 ? 132 LEU   A CB  1 
ATOM   369  C  CG  . LEU   A 1 132 ? -0.08090  18.88895  -26.59674 1.000 34.95584 ? 132 LEU   A CG  1 
ATOM   370  C  CD1 . LEU   A 1 132 ? 0.12711   18.35956  -25.16597 1.000 20.50235 ? 132 LEU   A CD1 1 
ATOM   371  C  CD2 . LEU   A 1 132 ? -0.73350  20.26495  -26.58957 1.000 23.86761 ? 132 LEU   A CD2 1 
ATOM   372  N  N   . LYS   A 1 133 ? 3.95846   18.09152  -28.61696 1.000 24.50209 ? 133 LYS   A N   1 
ATOM   373  C  CA  . LYS   A 1 133 ? 5.24985   18.44702  -29.20290 1.000 24.61749 ? 133 LYS   A CA  1 
ATOM   374  C  C   . LYS   A 1 133 ? 5.57619   17.59824  -30.42467 1.000 24.71638 ? 133 LYS   A C   1 
ATOM   375  O  O   . LYS   A 1 133 ? 6.16837   18.10760  -31.38176 1.000 22.10512 ? 133 LYS   A O   1 
ATOM   376  C  CB  . LYS   A 1 133 ? 6.36409   18.32208  -28.16069 1.000 24.39001 ? 133 LYS   A CB  1 
ATOM   377  C  CG  . LYS   A 1 133 ? 5.93090   18.79609  -26.76979 1.000 37.64005 ? 133 LYS   A CG  1 
ATOM   378  C  CD  . LYS   A 1 133 ? 6.70890   20.03914  -26.28983 1.000 49.41571 ? 133 LYS   A CD  1 
ATOM   379  C  CE  . LYS   A 1 133 ? 6.21577   20.51959  -24.90698 1.000 45.81775 ? 133 LYS   A CE  1 
ATOM   380  N  NZ  . LYS   A 1 133 ? 5.98591   21.99390  -24.78542 1.000 56.75229 ? 133 LYS   A NZ  1 
ATOM   381  N  N   . THR   A 1 134 ? 5.18039   16.32010  -30.43517 1.000 23.03499 ? 134 THR   A N   1 
ATOM   382  C  CA  . THR   A 1 134 ? 5.49790   15.48251  -31.59071 1.000 21.13378 ? 134 THR   A CA  1 
ATOM   383  C  C   . THR   A 1 134 ? 4.82840   16.01198  -32.85721 1.000 21.68107 ? 134 THR   A C   1 
ATOM   384  O  O   . THR   A 1 134 ? 5.45711   16.07566  -33.92186 1.000 23.02969 ? 134 THR   A O   1 
ATOM   385  C  CB  . THR   A 1 134 ? 5.09619   14.03413  -31.31850 1.000 22.83667 ? 134 THR   A CB  1 
ATOM   386  O  OG1 . THR   A 1 134 ? 5.90539   13.50083  -30.25816 1.000 16.08269 ? 134 THR   A OG1 1 
ATOM   387  C  CG2 . THR   A 1 134 ? 5.28633   13.18254  -32.55998 1.000 17.55382 ? 134 THR   A CG2 1 
ATOM   388  N  N   . PHE   A 1 135 ? 3.57386   16.45330  -32.74952 1.000 20.09067 ? 135 PHE   A N   1 
ATOM   389  C  CA  . PHE   A 1 135 ? 2.80707   16.89275  -33.90505 1.000 21.50962 ? 135 PHE   A CA  1 
ATOM   390  C  C   . PHE   A 1 135 ? 2.56210   18.39486  -33.91866 1.000 22.14426 ? 135 PHE   A C   1 
ATOM   391  O  O   . PHE   A 1 135 ? 1.70660   18.86966  -34.67762 1.000 22.86254 ? 135 PHE   A O   1 
ATOM   392  C  CB  . PHE   A 1 135 ? 1.48719   16.12183  -33.97207 1.000 23.05113 ? 135 PHE   A CB  1 
ATOM   393  C  CG  . PHE   A 1 135 ? 1.67867   14.66276  -34.27984 1.000 20.27136 ? 135 PHE   A CG  1 
ATOM   394  C  CD1 . PHE   A 1 135 ? 2.08268   14.26941  -35.54626 1.000 14.60672 ? 135 PHE   A CD1 1 
ATOM   395  C  CD2 . PHE   A 1 135 ? 1.50819   13.69667  -33.29913 1.000 14.64781 ? 135 PHE   A CD2 1 
ATOM   396  C  CE1 . PHE   A 1 135 ? 2.29392   12.93863  -35.84656 1.000 16.46042 ? 135 PHE   A CE1 1 
ATOM   397  C  CE2 . PHE   A 1 135 ? 1.72300   12.36637  -33.58945 1.000 16.39091 ? 135 PHE   A CE2 1 
ATOM   398  C  CZ  . PHE   A 1 135 ? 2.10641   11.98170  -34.86772 1.000 15.79455 ? 135 PHE   A CZ  1 
ATOM   399  N  N   . LYS   A 1 136 ? 3.30762   19.15316  -33.11585 1.000 20.68137 ? 136 LYS   A N   1 
ATOM   400  C  CA  . LYS   A 1 136 ? 3.24510   20.62104  -33.13454 1.000 19.19380 ? 136 LYS   A CA  1 
ATOM   401  C  C   . LYS   A 1 136 ? 1.80733   21.11080  -33.00202 1.000 21.48324 ? 136 LYS   A C   1 
ATOM   402  O  O   . LYS   A 1 136 ? 1.39335   22.07835  -33.65254 1.000 19.10808 ? 136 LYS   A O   1 
ATOM   403  C  CB  . LYS   A 1 136 ? 3.87074   21.19341  -34.40386 1.000 19.37778 ? 136 LYS   A CB  1 
ATOM   404  C  CG  . LYS   A 1 136 ? 5.14574   20.52033  -34.88711 1.000 26.34467 ? 136 LYS   A CG  1 
ATOM   405  C  CD  . LYS   A 1 136 ? 6.28922   20.69983  -33.92546 1.000 27.21343 ? 136 LYS   A CD  1 
ATOM   406  C  CE  . LYS   A 1 136 ? 7.61182   20.34043  -34.60935 1.000 41.41922 ? 136 LYS   A CE  1 
ATOM   407  N  NZ  . LYS   A 1 136 ? 8.69025   20.05085  -33.63085 1.000 25.87373 ? 136 LYS   A NZ  1 
ATOM   408  N  N   . ILE   A 1 137 ? 1.02940   20.40541  -32.18808 1.000 19.32386 ? 137 ILE   A N   1 
ATOM   409  C  CA  . ILE   A 1 137 ? -0.35751  20.76990  -31.89959 1.000 18.18472 ? 137 ILE   A CA  1 
ATOM   410  C  C   . ILE   A 1 137 ? -0.33002  21.93249  -30.91158 1.000 21.26090 ? 137 ILE   A C   1 
ATOM   411  O  O   . ILE   A 1 137 ? 0.14142   21.75723  -29.77890 1.000 18.18654 ? 137 ILE   A O   1 
ATOM   412  C  CB  . ILE   A 1 137 ? -1.13881  19.57147  -31.33092 1.000 15.89017 ? 137 ILE   A CB  1 
ATOM   413  C  CG1 . ILE   A 1 137 ? -1.00201  18.35614  -32.24785 1.000 18.74262 ? 137 ILE   A CG1 1 
ATOM   414  C  CG2 . ILE   A 1 137 ? -2.59913  19.91522  -31.11953 1.000 12.56033 ? 137 ILE   A CG2 1 
ATOM   415  C  CD1 . ILE   A 1 137 ? -1.64497  17.08675  -31.69961 1.000 13.00211 ? 137 ILE   A CD1 1 
ATOM   416  N  N   . PRO   A 1 138 ? -0.79748  23.12731  -31.27884 1.000 18.94741 ? 138 PRO   A N   1 
ATOM   417  C  CA  . PRO   A 1 138 ? -0.87325  24.20933  -30.28890 1.000 19.97496 ? 138 PRO   A CA  1 
ATOM   418  C  C   . PRO   A 1 138 ? -1.84519  23.82508  -29.18556 1.000 22.74927 ? 138 PRO   A C   1 
ATOM   419  O  O   . PRO   A 1 138 ? -2.92940  23.30546  -29.45849 1.000 22.39314 ? 138 PRO   A O   1 
ATOM   420  C  CB  . PRO   A 1 138 ? -1.38510  25.40793  -31.09906 1.000 26.16684 ? 138 PRO   A CB  1 
ATOM   421  C  CG  . PRO   A 1 138 ? -1.19609  25.02398  -32.56102 1.000 23.19833 ? 138 PRO   A CG  1 
ATOM   422  C  CD  . PRO   A 1 138 ? -1.30601  23.53277  -32.60001 1.000 21.26084 ? 138 PRO   A CD  1 
ATOM   423  N  N   . VAL   A 1 139 ? -1.45615  24.08930  -27.93063 1.000 20.93381 ? 139 VAL   A N   1 
ATOM   424  C  CA  . VAL   A 1 139 ? -2.28310  23.66299  -26.79916 1.000 20.08905 ? 139 VAL   A CA  1 
ATOM   425  C  C   . VAL   A 1 139 ? -3.66951  24.30232  -26.85916 1.000 22.47368 ? 139 VAL   A C   1 
ATOM   426  O  O   . VAL   A 1 139 ? -4.67991  23.64696  -26.57096 1.000 21.68044 ? 139 VAL   A O   1 
ATOM   427  C  CB  . VAL   A 1 139 ? -1.57412  23.94431  -25.45552 1.000 26.26187 ? 139 VAL   A CB  1 
ATOM   428  C  CG1 . VAL   A 1 139 ? -1.25905  25.40743  -25.29249 1.000 27.33508 ? 139 VAL   A CG1 1 
ATOM   429  C  CG2 . VAL   A 1 139 ? -2.41318  23.42398  -24.26429 1.000 23.82717 ? 139 VAL   A CG2 1 
ATOM   430  N  N   . ASP   A 1 140 ? -3.75633  25.57224  -27.25947 1.000 23.61593 ? 140 ASP   A N   1 
ATOM   431  C  CA  . ASP   A 1 140 ? -5.06950  26.21482  -27.29546 1.000 18.48752 ? 140 ASP   A CA  1 
ATOM   432  C  C   . ASP   A 1 140 ? -5.95302  25.61290  -28.38132 1.000 18.75070 ? 140 ASP   A C   1 
ATOM   433  O  O   . ASP   A 1 140 ? -7.16188  25.44702  -28.18224 1.000 18.16320 ? 140 ASP   A O   1 
ATOM   434  C  CB  . ASP   A 1 140 ? -4.91740  27.72543  -27.48271 1.000 26.53762 ? 140 ASP   A CB  1 
ATOM   435  C  CG  . ASP   A 1 140 ? -4.04879  28.08320  -28.67205 1.000 34.13469 ? 140 ASP   A CG  1 
ATOM   436  O  OD1 . ASP   A 1 140 ? -2.81175  27.86526  -28.61302 1.000 39.43616 ? 140 ASP   A OD1 1 
ATOM   437  O  OD2 . ASP   A 1 140 ? -4.60179  28.59780  -29.66604 1.000 44.01589 ? 140 ASP   A OD2 1 
ATOM   438  N  N   . THR   A 1 141 ? -5.36881  25.30219  -29.54171 1.000 20.50640 ? 141 THR   A N   1 
ATOM   439  C  CA  . THR   A 1 141 ? -6.08712  24.60187  -30.60441 1.000 17.16890 ? 141 THR   A CA  1 
ATOM   440  C  C   . THR   A 1 141 ? -6.61185  23.25717  -30.11954 1.000 17.38737 ? 141 THR   A C   1 
ATOM   441  O  O   . THR   A 1 141 ? -7.74072  22.86703  -30.44092 1.000 16.58491 ? 141 THR   A O   1 
ATOM   442  C  CB  . THR   A 1 141 ? -5.15433  24.37149  -31.80286 1.000 23.67830 ? 141 THR   A CB  1 
ATOM   443  O  OG1 . THR   A 1 141 ? -4.35608  25.53862  -32.03396 1.000 24.69967 ? 141 THR   A OG1 1 
ATOM   444  C  CG2 . THR   A 1 141 ? -5.94143  24.01453  -33.08350 1.000 15.23323 ? 141 THR   A CG2 1 
ATOM   445  N  N   . LEU   A 1 142 ? -5.78105  22.51157  -29.38500 1.000 18.57344 ? 142 LEU   A N   1 
ATOM   446  C  CA  . LEU   A 1 142 ? -6.20102  21.21426  -28.87408 1.000 17.59419 ? 142 LEU   A CA  1 
ATOM   447  C  C   . LEU   A 1 142 ? -7.39449  21.36055  -27.94358 1.000 18.24399 ? 142 LEU   A C   1 
ATOM   448  O  O   . LEU   A 1 142 ? -8.36839  20.61350  -28.04771 1.000 20.26626 ? 142 LEU   A O   1 
ATOM   449  C  CB  . LEU   A 1 142 ? -5.04359  20.51847  -28.15864 1.000 13.74989 ? 142 LEU   A CB  1 
ATOM   450  C  CG  . LEU   A 1 142 ? -5.38039  19.15260  -27.53894 1.000 14.28180 ? 142 LEU   A CG  1 
ATOM   451  C  CD1 . LEU   A 1 142 ? -5.88876  18.15467  -28.56943 1.000 9.32037  ? 142 LEU   A CD1 1 
ATOM   452  C  CD2 . LEU   A 1 142 ? -4.15333  18.59306  -26.83862 1.000 18.25733 ? 142 LEU   A CD2 1 
ATOM   453  N  N   . ILE   A 1 143 ? -7.34591  22.33558  -27.03717 1.000 19.33880 ? 143 ILE   A N   1 
ATOM   454  C  CA  . ILE   A 1 143 ? -8.45124  22.50049  -26.10234 1.000 19.16009 ? 143 ILE   A CA  1 
ATOM   455  C  C   . ILE   A 1 143 ? -9.69295  22.98902  -26.83243 1.000 16.75129 ? 143 ILE   A C   1 
ATOM   456  O  O   . ILE   A 1 143 ? -10.80838 22.52238  -26.56931 1.000 22.26030 ? 143 ILE   A O   1 
ATOM   457  C  CB  . ILE   A 1 143 ? -8.05954  23.45078  -24.95957 1.000 16.64713 ? 143 ILE   A CB  1 
ATOM   458  C  CG1 . ILE   A 1 143 ? -6.90108  22.86463  -24.16495 1.000 22.90037 ? 143 ILE   A CG1 1 
ATOM   459  C  CG2 . ILE   A 1 143 ? -9.23667  23.67063  -24.04936 1.000 16.94143 ? 143 ILE   A CG2 1 
ATOM   460  C  CD1 . ILE   A 1 143 ? -7.26895  21.58282  -23.46374 1.000 34.37212 ? 143 ILE   A CD1 1 
ATOM   461  N  N   . THR   A 1 144 ? -9.53037  23.94653  -27.74516 1.000 16.52101 ? 144 THR   A N   1 
ATOM   462  C  CA  . THR   A 1 144 ? -10.68123 24.42975  -28.49935 1.000 12.83119 ? 144 THR   A CA  1 
ATOM   463  C  C   . THR   A 1 144 ? -11.35987 23.28090  -29.22157 1.000 15.94430 ? 144 THR   A C   1 
ATOM   464  O  O   . THR   A 1 144 ? -12.58298 23.14356  -29.17561 1.000 13.24869 ? 144 THR   A O   1 
ATOM   465  C  CB  . THR   A 1 144 ? -10.26939 25.50438  -29.50664 1.000 14.96813 ? 144 THR   A CB  1 
ATOM   466  O  OG1 . THR   A 1 144 ? -9.37978  26.45360  -28.89244 1.000 15.69701 ? 144 THR   A OG1 1 
ATOM   467  C  CG2 . THR   A 1 144 ? -11.50668 26.22862  -30.02464 1.000 11.38595 ? 144 THR   A CG2 1 
ATOM   468  N  N   . TYR   A 1 145 ? -10.57833 22.43997  -29.90162 1.000 13.29202 ? 145 TYR   A N   1 
ATOM   469  C  CA  . TYR   A 1 145 ? -11.19789 21.35252  -30.64200 1.000 17.22321 ? 145 TYR   A CA  1 
ATOM   470  C  C   . TYR   A 1 145 ? -11.87972 20.38221  -29.69592 1.000 15.75945 ? 145 TYR   A C   1 
ATOM   471  O  O   . TYR   A 1 145 ? -13.02515 19.98596  -29.92003 1.000 16.41924 ? 145 TYR   A O   1 
ATOM   472  C  CB  . TYR   A 1 145 ? -10.17562 20.61040  -31.50049 1.000 15.56445 ? 145 TYR   A CB  1 
ATOM   473  C  CG  . TYR   A 1 145 ? -10.78355 19.36465  -32.09222 1.000 13.30455 ? 145 TYR   A CG  1 
ATOM   474  C  CD1 . TYR   A 1 145 ? -11.58988 19.43950  -33.22128 1.000 12.44685 ? 145 TYR   A CD1 1 
ATOM   475  C  CD2 . TYR   A 1 145 ? -10.58406 18.11324  -31.49782 1.000 16.65196 ? 145 TYR   A CD2 1 
ATOM   476  C  CE1 . TYR   A 1 145 ? -12.16627 18.30789  -33.76726 1.000 12.65492 ? 145 TYR   A CE1 1 
ATOM   477  C  CE2 . TYR   A 1 145 ? -11.16853 16.96071  -32.02989 1.000 13.83584 ? 145 TYR   A CE2 1 
ATOM   478  C  CZ  . TYR   A 1 145 ? -11.95438 17.07215  -33.16745 1.000 12.15769 ? 145 TYR   A CZ  1 
ATOM   479  O  OH  . TYR   A 1 145 ? -12.52192 15.95726  -33.71451 1.000 14.78621 ? 145 TYR   A OH  1 
ATOM   480  N  N   . LEU   A 1 146 ? -11.17659 19.98594  -28.63377 1.000 12.76563 ? 146 LEU   A N   1 
ATOM   481  C  CA  . LEU   A 1 146 ? -11.71444 19.00142  -27.70391 1.000 17.94566 ? 146 LEU   A CA  1 
ATOM   482  C  C   . LEU   A 1 146 ? -13.03782 19.45650  -27.11326 1.000 15.61613 ? 146 LEU   A C   1 
ATOM   483  O  O   . LEU   A 1 146 ? -13.94967 18.64216  -26.93066 1.000 18.80882 ? 146 LEU   A O   1 
ATOM   484  C  CB  . LEU   A 1 146 ? -10.70007 18.71847  -26.59249 1.000 14.22920 ? 146 LEU   A CB  1 
ATOM   485  C  CG  . LEU   A 1 146 ? -9.48491  17.90672  -27.04394 1.000 16.64824 ? 146 LEU   A CG  1 
ATOM   486  C  CD1 . LEU   A 1 146 ? -8.48217  17.78503  -25.90915 1.000 12.54471 ? 146 LEU   A CD1 1 
ATOM   487  C  CD2 . LEU   A 1 146 ? -9.95957  16.54699  -27.48614 1.000 16.78388 ? 146 LEU   A CD2 1 
ATOM   488  N  N   . MET   A 1 147 ? -13.16300 20.74879  -26.79990 1.000 17.59633 ? 147 MET   A N   1 
ATOM   489  C  CA  . MET   A 1 147 ? -14.40800 21.24264  -26.20922 1.000 19.97327 ? 147 MET   A CA  1 
ATOM   490  C  C   . MET   A 1 147 ? -15.53954 21.25616  -27.22647 1.000 20.97396 ? 147 MET   A C   1 
ATOM   491  O  O   . MET   A 1 147 ? -16.68783 20.93937  -26.88897 1.000 21.79813 ? 147 MET   A O   1 
ATOM   492  C  CB  . MET   A 1 147 ? -14.21827 22.64330  -25.63254 1.000 21.09370 ? 147 MET   A CB  1 
ATOM   493  C  CG  . MET   A 1 147 ? -13.14301 22.71725  -24.58980 1.000 21.22737 ? 147 MET   A CG  1 
ATOM   494  S  SD  . MET   A 1 147 ? -12.91372 24.36169  -23.89754 1.000 36.88298 ? 147 MET   A SD  1 
ATOM   495  C  CE  . MET   A 1 147 ? -14.22348 24.45411  -22.69122 1.000 32.51677 ? 147 MET   A CE  1 
ATOM   496  N  N   . THR   A 1 148 ? -15.24317 21.63557  -28.47258 1.000 16.82742 ? 148 THR   A N   1 
ATOM   497  C  CA  . THR   A 1 148 ? -16.26799 21.57167  -29.50830 1.000 17.00091 ? 148 THR   A CA  1 
ATOM   498  C  C   . THR   A 1 148 ? -16.68229 20.13029  -29.78363 1.000 17.97660 ? 148 THR   A C   1 
ATOM   499  O  O   . THR   A 1 148 ? -17.85967 19.84582  -30.03355 1.000 15.56848 ? 148 THR   A O   1 
ATOM   500  C  CB  . THR   A 1 148 ? -15.75285 22.21356  -30.78970 1.000 14.64553 ? 148 THR   A CB  1 
ATOM   501  O  OG1 . THR   A 1 148 ? -15.16700 23.48196  -30.47834 1.000 20.32871 ? 148 THR   A OG1 1 
ATOM   502  C  CG2 . THR   A 1 148 ? -16.88533 22.38136  -31.77749 1.000 12.83467 ? 148 THR   A CG2 1 
ATOM   503  N  N   . LEU   A 1 149 ? -15.71863 19.21450  -29.79119 1.000 16.45820 ? 149 LEU   A N   1 
ATOM   504  C  CA  . LEU   A 1 149 ? -16.05563 17.80686  -29.97994 1.000 13.67428 ? 149 LEU   A CA  1 
ATOM   505  C  C   . LEU   A 1 149 ? -16.93727 17.31605  -28.84129 1.000 14.10376 ? 149 LEU   A C   1 
ATOM   506  O  O   . LEU   A 1 149 ? -17.98045 16.69429  -29.07656 1.000 13.23328 ? 149 LEU   A O   1 
ATOM   507  C  CB  . LEU   A 1 149 ? -14.78256 16.96664  -30.08107 1.000 9.57929  ? 149 LEU   A CB  1 
ATOM   508  C  CG  . LEU   A 1 149 ? -15.00060 15.45594  -30.19186 1.000 13.27906 ? 149 LEU   A CG  1 
ATOM   509  C  CD1 . LEU   A 1 149 ? -15.70461 15.07546  -31.52178 1.000 7.17313  ? 149 LEU   A CD1 1 
ATOM   510  C  CD2 . LEU   A 1 149 ? -13.65478 14.75279  -30.03808 1.000 10.68270 ? 149 LEU   A CD2 1 
ATOM   511  N  N   . GLU   A 1 150 ? -16.52470 17.59537  -27.59458 1.000 12.16479 ? 150 GLU   A N   1 
ATOM   512  C  CA  . GLU   A 1 150 ? -17.31851 17.21508  -26.43586 1.000 12.65062 ? 150 GLU   A CA  1 
ATOM   513  C  C   . GLU   A 1 150 ? -18.72972 17.78059  -26.52943 1.000 14.55071 ? 150 GLU   A C   1 
ATOM   514  O  O   . GLU   A 1 150 ? -19.70459 17.07539  -26.24143 1.000 16.44854 ? 150 GLU   A O   1 
ATOM   515  C  CB  . GLU   A 1 150 ? -16.62531 17.66155  -25.13897 1.000 13.10838 ? 150 GLU   A CB  1 
ATOM   516  C  CG  . GLU   A 1 150 ? -17.25618 17.06952  -23.87936 1.000 14.44217 ? 150 GLU   A CG  1 
ATOM   517  C  CD  . GLU   A 1 150 ? -16.22954 16.72858  -22.81947 1.000 18.15050 ? 150 GLU   A CD  1 
ATOM   518  O  OE1 . GLU   A 1 150 ? -15.14197 17.35304  -22.83047 1.000 15.06666 ? 150 GLU   A OE1 1 
ATOM   519  O  OE2 . GLU   A 1 150 ? -16.50120 15.81833  -21.99181 1.000 15.02021 ? 150 GLU   A OE2 1 
ATOM   520  N  N   . ASP   A 1 151 ? -18.86603 19.02618  -26.99590 1.000 17.11396 ? 151 ASP   A N   1 
ATOM   521  C  CA  . ASP   A 1 151 ? -20.19072 19.63705  -27.10106 1.000 15.39978 ? 151 ASP   A CA  1 
ATOM   522  C  C   . ASP   A 1 151 ? -21.10918 18.85692  -28.01909 1.000 14.38780 ? 151 ASP   A C   1 
ATOM   523  O  O   . ASP   A 1 151 ? -22.32230 18.82481  -27.78406 1.000 19.14092 ? 151 ASP   A O   1 
ATOM   524  C  CB  . ASP   A 1 151 ? -20.09253 21.08049  -27.60371 1.000 22.29899 ? 151 ASP   A CB  1 
ATOM   525  C  CG  . ASP   A 1 151 ? -19.47014 22.01360  -26.58222 1.000 26.28886 ? 151 ASP   A CG  1 
ATOM   526  O  OD1 . ASP   A 1 151 ? -19.35790 21.60349  -25.39350 1.000 18.90826 ? 151 ASP   A OD1 1 
ATOM   527  O  OD2 . ASP   A 1 151 ? -19.09527 23.15257  -26.97626 1.000 25.77057 ? 151 ASP   A OD2 1 
ATOM   528  N  N   . HIS   A 1 152 ? -20.56427 18.23222  -29.07116 1.000 14.88333 ? 152 HIS   A N   1 
ATOM   529  C  CA  . HIS   A 1 152 ? -21.40077 17.54524  -30.05098 1.000 13.52934 ? 152 HIS   A CA  1 
ATOM   530  C  C   . HIS   A 1 152 ? -21.73714 16.10337  -29.65924 1.000 14.31062 ? 152 HIS   A C   1 
ATOM   531  O  O   . HIS   A 1 152 ? -22.45484 15.42640  -30.40394 1.000 10.65127 ? 152 HIS   A O   1 
ATOM   532  C  CB  . HIS   A 1 152 ? -20.73855 17.60171  -31.42942 1.000 12.28017 ? 152 HIS   A CB  1 
ATOM   533  C  CG  . HIS   A 1 152 ? -20.77227 18.97150  -32.03537 1.000 13.69917 ? 152 HIS   A CG  1 
ATOM   534  N  ND1 . HIS   A 1 152 ? -19.99978 20.01414  -31.56521 1.000 14.91479 ? 152 HIS   A ND1 1 
ATOM   535  C  CD2 . HIS   A 1 152 ? -21.52982 19.48638  -33.03077 1.000 12.33310 ? 152 HIS   A CD2 1 
ATOM   536  C  CE1 . HIS   A 1 152 ? -20.26135 21.10485  -32.26330 1.000 13.08761 ? 152 HIS   A CE1 1 
ATOM   537  N  NE2 . HIS   A 1 152 ? -21.19223 20.81408  -33.15210 1.000 14.61723 ? 152 HIS   A NE2 1 
ATOM   538  N  N   . TYR   A 1 153 ? -21.23152 15.61427  -28.52466 1.000 13.46539 ? 153 TYR   A N   1 
ATOM   539  C  CA  . TYR   A 1 153 ? -21.89794 14.52074  -27.82520 1.000 16.55436 ? 153 TYR   A CA  1 
ATOM   540  C  C   . TYR   A 1 153 ? -23.12453 15.08168  -27.10351 1.000 19.74241 ? 153 TYR   A C   1 
ATOM   541  O  O   . TYR   A 1 153 ? -23.11973 16.22287  -26.62000 1.000 18.79769 ? 153 TYR   A O   1 
ATOM   542  C  CB  . TYR   A 1 153 ? -20.96231 13.82946  -26.83023 1.000 14.36406 ? 153 TYR   A CB  1 
ATOM   543  C  CG  . TYR   A 1 153 ? -19.94479 12.90304  -27.48775 1.000 16.17483 ? 153 TYR   A CG  1 
ATOM   544  C  CD1 . TYR   A 1 153 ? -18.72140 13.39035  -27.95221 1.000 7.89545  ? 153 TYR   A CD1 1 
ATOM   545  C  CD2 . TYR   A 1 153 ? -20.21177 11.55230  -27.65385 1.000 9.32408  ? 153 TYR   A CD2 1 
ATOM   546  C  CE1 . TYR   A 1 153 ? -17.80357 12.55227  -28.54463 1.000 7.86238  ? 153 TYR   A CE1 1 
ATOM   547  C  CE2 . TYR   A 1 153 ? -19.28980 10.70896  -28.26389 1.000 8.27483  ? 153 TYR   A CE2 1 
ATOM   548  C  CZ  . TYR   A 1 153 ? -18.09744 11.22036  -28.70877 1.000 8.28445  ? 153 TYR   A CZ  1 
ATOM   549  O  OH  . TYR   A 1 153 ? -17.17796 10.38448  -29.30332 1.000 9.95174  ? 153 TYR   A OH  1 
ATOM   550  N  N   . HIS   A 1 154 ? -24.17860 14.28031  -27.06905 1.000 13.41481 ? 154 HIS   A N   1 
ATOM   551  C  CA  . HIS   A 1 154 ? -25.47875 14.67968  -26.55014 1.000 20.57478 ? 154 HIS   A CA  1 
ATOM   552  C  C   . HIS   A 1 154 ? -25.49838 14.46891  -25.03948 1.000 24.86860 ? 154 HIS   A C   1 
ATOM   553  O  O   . HIS   A 1 154 ? -25.32137 13.33864  -24.56036 1.000 19.35160 ? 154 HIS   A O   1 
ATOM   554  C  CB  . HIS   A 1 154 ? -26.58512 13.88043  -27.24201 1.000 14.47130 ? 154 HIS   A CB  1 
ATOM   555  C  CG  . HIS   A 1 154 ? -26.68886 14.14744  -28.71703 1.000 14.88971 ? 154 HIS   A CG  1 
ATOM   556  N  ND1 . HIS   A 1 154 ? -27.85950 13.98886  -29.42488 1.000 18.74869 ? 154 HIS   A ND1 1 
ATOM   557  C  CD2 . HIS   A 1 154 ? -25.75546 14.52935  -29.62183 1.000 13.79384 ? 154 HIS   A CD2 1 
ATOM   558  C  CE1 . HIS   A 1 154 ? -27.65176 14.28467  -30.69672 1.000 18.32375 ? 154 HIS   A CE1 1 
ATOM   559  N  NE2 . HIS   A 1 154 ? -26.38185 14.61899  -30.84217 1.000 20.36455 ? 154 HIS   A NE2 1 
ATOM   560  N  N   . ALA   A 1 155 ? -25.68848 15.56117  -24.28883 1.000 21.22091 ? 155 ALA   A N   1 
ATOM   561  C  CA  . ALA   A 1 155 ? -25.72483 15.45982  -22.83216 1.000 24.48773 ? 155 ALA   A CA  1 
ATOM   562  C  C   . ALA   A 1 155 ? -27.00465 14.80470  -22.33411 1.000 16.54678 ? 155 ALA   A C   1 
ATOM   563  O  O   . ALA   A 1 155 ? -27.05076 14.37244  -21.18054 1.000 20.10861 ? 155 ALA   A O   1 
ATOM   564  C  CB  . ALA   A 1 155 ? -25.55553 16.83993  -22.18840 1.000 22.01580 ? 155 ALA   A CB  1 
ATOM   565  N  N   . ASP   A 1 156 ? -28.02953 14.70646  -23.17367 1.000 15.57219 ? 156 ASP   A N   1 
ATOM   566  C  CA  . ASP   A 1 156 ? -29.27708 14.05714  -22.79663 1.000 22.69876 ? 156 ASP   A CA  1 
ATOM   567  C  C   . ASP   A 1 156 ? -29.35241 12.60794  -23.24435 1.000 23.06965 ? 156 ASP   A C   1 
ATOM   568  O  O   . ASP   A 1 156 ? -30.43571 12.02208  -23.23440 1.000 21.43417 ? 156 ASP   A O   1 
ATOM   569  C  CB  . ASP   A 1 156 ? -30.48112 14.81899  -23.35041 1.000 20.36905 ? 156 ASP   A CB  1 
ATOM   570  C  CG  . ASP   A 1 156 ? -30.23784 15.38209  -24.71545 1.000 28.48479 ? 156 ASP   A CG  1 
ATOM   571  O  OD1 . ASP   A 1 156 ? -29.24560 14.98095  -25.36843 1.000 25.94332 ? 156 ASP   A OD1 1 
ATOM   572  O  OD2 . ASP   A 1 156 ? -31.04207 16.24622  -25.12456 1.000 36.62792 ? 156 ASP   A OD2 1 
ATOM   573  N  N   . VAL   A 1 157 ? -28.24070 12.01192  -23.64513 1.000 18.14310 ? 157 VAL   A N   1 
ATOM   574  C  CA  . VAL   A 1 157 ? -28.22679 10.60800  -24.00617 1.000 16.79107 ? 157 VAL   A CA  1 
ATOM   575  C  C   . VAL   A 1 157 ? -27.52114 9.87829   -22.87404 1.000 16.23063 ? 157 VAL   A C   1 
ATOM   576  O  O   . VAL   A 1 157 ? -26.44882 10.30826  -22.42181 1.000 14.63967 ? 157 VAL   A O   1 
ATOM   577  C  CB  . VAL   A 1 157 ? -27.57272 10.39708  -25.38171 1.000 17.77326 ? 157 VAL   A CB  1 
ATOM   578  C  CG1 . VAL   A 1 157 ? -26.97471 9.03155   -25.48943 1.000 16.50938 ? 157 VAL   A CG1 1 
ATOM   579  C  CG2 . VAL   A 1 157 ? -28.63663 10.62399  -26.48592 1.000 12.09416 ? 157 VAL   A CG2 1 
ATOM   580  N  N   . ALA   A 1 158 ? -28.14601 8.79655   -22.39694 1.000 10.70944 ? 158 ALA   A N   1 
ATOM   581  C  CA  . ALA   A 1 158 ? -27.72875 8.15724   -21.15181 1.000 14.10209 ? 158 ALA   A CA  1 
ATOM   582  C  C   . ALA   A 1 158 ? -26.41295 7.39168   -21.29549 1.000 11.22341 ? 158 ALA   A C   1 
ATOM   583  O  O   . ALA   A 1 158 ? -25.58621 7.39044   -20.37653 1.000 11.46901 ? 158 ALA   A O   1 
ATOM   584  C  CB  . ALA   A 1 158 ? -28.84110 7.22723   -20.66226 1.000 16.10604 ? 158 ALA   A CB  1 
ATOM   585  N  N   . TYR   A 1 159 ? -26.21267 6.68863   -22.40186 1.000 14.00042 ? 159 TYR   A N   1 
ATOM   586  C  CA  . TYR   A 1 159 ? -24.98183 5.92092   -22.55792 1.000 11.21684 ? 159 TYR   A CA  1 
ATOM   587  C  C   . TYR   A 1 159 ? -24.01745 6.57115   -23.54143 1.000 9.43833  ? 159 TYR   A C   1 
ATOM   588  O  O   . TYR   A 1 159 ? -22.89793 6.92647   -23.16266 1.000 7.84681  ? 159 TYR   A O   1 
ATOM   589  C  CB  . TYR   A 1 159 ? -25.27626 4.47590   -22.98128 1.000 9.42415  ? 159 TYR   A CB  1 
ATOM   590  C  CG  . TYR   A 1 159 ? -23.99021 3.65667   -23.05336 1.000 13.41085 ? 159 TYR   A CG  1 
ATOM   591  C  CD1 . TYR   A 1 159 ? -23.16732 3.68947   -24.19128 1.000 10.44913 ? 159 TYR   A CD1 1 
ATOM   592  C  CD2 . TYR   A 1 159 ? -23.58046 2.88498   -21.97368 1.000 7.22574  ? 159 TYR   A CD2 1 
ATOM   593  C  CE1 . TYR   A 1 159 ? -21.95772 2.95257   -24.23727 1.000 8.79389  ? 159 TYR   A CE1 1 
ATOM   594  C  CE2 . TYR   A 1 159 ? -22.41146 2.14416   -22.02134 1.000 7.02035  ? 159 TYR   A CE2 1 
ATOM   595  C  CZ  . TYR   A 1 159 ? -21.59675 2.18378   -23.13976 1.000 8.88613  ? 159 TYR   A CZ  1 
ATOM   596  O  OH  . TYR   A 1 159 ? -20.42513 1.43368   -23.16183 1.000 10.98347 ? 159 TYR   A OH  1 
ATOM   597  N  N   . HIS   A 1 160 ? -24.42437 6.73358   -24.80717 1.000 10.63645 ? 160 HIS   A N   1 
ATOM   598  C  CA  . HIS   A 1 160 ? -23.52350 7.20452   -25.86522 1.000 6.71314  ? 160 HIS   A CA  1 
ATOM   599  C  C   . HIS   A 1 160 ? -23.30372 8.71875   -25.79711 1.000 7.69493  ? 160 HIS   A C   1 
ATOM   600  O  O   . HIS   A 1 160 ? -23.61932 9.47839   -26.71118 1.000 8.53648  ? 160 HIS   A O   1 
ATOM   601  C  CB  . HIS   A 1 160 ? -24.05019 6.76930   -27.22347 1.000 5.93168  ? 160 HIS   A CB  1 
ATOM   602  C  CG  . HIS   A 1 160 ? -24.00878 5.28913   -27.42756 1.000 11.51473 ? 160 HIS   A CG  1 
ATOM   603  N  ND1 . HIS   A 1 160 ? -25.11692 4.48481   -27.26434 1.000 7.91219  ? 160 HIS   A ND1 1 
ATOM   604  C  CD2 . HIS   A 1 160 ? -22.98572 4.46218   -27.76638 1.000 8.64899  ? 160 HIS   A CD2 1 
ATOM   605  C  CE1 . HIS   A 1 160 ? -24.78301 3.23090   -27.51898 1.000 7.82751  ? 160 HIS   A CE1 1 
ATOM   606  N  NE2 . HIS   A 1 160 ? -23.49329 3.18849   -27.80911 1.000 9.79502  ? 160 HIS   A NE2 1 
ATOM   607  N  N   . ASN   A 1 161 ? -22.69907 9.14352   -24.69592 1.000 8.35937  ? 161 ASN   A N   1 
ATOM   608  C  CA  . ASN   A 1 161 ? -22.38566 10.53954  -24.46575 1.000 10.89928 ? 161 ASN   A CA  1 
ATOM   609  C  C   . ASN   A 1 161 ? -20.86355 10.74959  -24.34641 1.000 11.18168 ? 161 ASN   A C   1 
ATOM   610  O  O   . ASN   A 1 161 ? -20.03799 9.87258   -24.67961 1.000 8.52740  ? 161 ASN   A O   1 
ATOM   611  C  CB  . ASN   A 1 161 ? -23.13826 11.01913  -23.22761 1.000 8.95754  ? 161 ASN   A CB  1 
ATOM   612  C  CG  . ASN   A 1 161 ? -22.86247 10.17391  -22.03350 1.000 7.92482  ? 161 ASN   A CG  1 
ATOM   613  O  OD1 . ASN   A 1 161 ? -21.71364 10.01819  -21.63720 1.000 10.80038 ? 161 ASN   A OD1 1 
ATOM   614  N  ND2 . ASN   A 1 161 ? -23.91071 9.62048   -21.43402 1.000 12.80043 ? 161 ASN   A ND2 1 
ATOM   615  N  N   . ASN   A 1 162 ? -20.50204 11.93573  -23.85676 1.000 10.72151 ? 162 ASN   A N   1 
ATOM   616  C  CA  . ASN   A 1 162 ? -19.10241 12.31581  -23.73578 1.000 9.73146  ? 162 ASN   A CA  1 
ATOM   617  C  C   . ASN   A 1 162 ? -18.38244 11.49948  -22.67703 1.000 10.99010 ? 162 ASN   A C   1 
ATOM   618  O  O   . ASN   A 1 162 ? -17.16400 11.32629  -22.77117 1.000 13.74774 ? 162 ASN   A O   1 
ATOM   619  C  CB  . ASN   A 1 162 ? -18.98641 13.79917  -23.39466 1.000 14.59239 ? 162 ASN   A CB  1 
ATOM   620  C  CG  . ASN   A 1 162 ? -19.65937 14.14466  -22.07351 1.000 12.96784 ? 162 ASN   A CG  1 
ATOM   621  O  OD1 . ASN   A 1 162 ? -20.71723 13.61125  -21.77158 1.000 18.03564 ? 162 ASN   A OD1 1 
ATOM   622  N  ND2 . ASN   A 1 162 ? -19.04030 15.01580  -21.28303 1.000 12.48202 ? 162 ASN   A ND2 1 
ATOM   623  N  N   . ILE   A 1 163 ? -19.09250 11.02950  -21.64113 1.000 8.95736  ? 163 ILE   A N   1 
ATOM   624  C  CA  . ILE   A 1 163 ? -18.44929 10.15027  -20.67166 1.000 9.80105  ? 163 ILE   A CA  1 
ATOM   625  C  C   . ILE   A 1 163 ? -18.01388 8.86053   -21.35056 1.000 9.01594  ? 163 ILE   A C   1 
ATOM   626  O  O   . ILE   A 1 163 ? -16.88383 8.40252   -21.17046 1.000 11.20519 ? 163 ILE   A O   1 
ATOM   627  C  CB  . ILE   A 1 163 ? -19.37392 9.86133   -19.48064 1.000 10.18845 ? 163 ILE   A CB  1 
ATOM   628  C  CG1 . ILE   A 1 163 ? -20.02398 11.15138  -18.99023 1.000 11.98254 ? 163 ILE   A CG1 1 
ATOM   629  C  CG2 . ILE   A 1 163 ? -18.55890 9.21191   -18.35417 1.000 9.58502  ? 163 ILE   A CG2 1 
ATOM   630  C  CD1 . ILE   A 1 163 ? -21.01409 10.92930  -17.88123 1.000 13.02556 ? 163 ILE   A CD1 1 
ATOM   631  N  N   . HIS   A 1 164 ? -18.90700 8.25791   -22.14334 1.000 8.09014  ? 164 HIS   A N   1 
ATOM   632  C  CA  . HIS   A 1 164 ? -18.53528 7.07167   -22.91448 1.000 9.95549  ? 164 HIS   A CA  1 
ATOM   633  C  C   . HIS   A 1 164 ? -17.29987 7.33063   -23.76691 1.000 9.20932  ? 164 HIS   A C   1 
ATOM   634  O  O   . HIS   A 1 164 ? -16.36803 6.52215   -23.78349 1.000 7.61616  ? 164 HIS   A O   1 
ATOM   635  C  CB  . HIS   A 1 164 ? -19.68995 6.61849   -23.80411 1.000 9.33199  ? 164 HIS   A CB  1 
ATOM   636  C  CG  . HIS   A 1 164 ? -19.32767 5.49594   -24.73364 1.000 9.24439  ? 164 HIS   A CG  1 
ATOM   637  N  ND1 . HIS   A 1 164 ? -18.89064 4.27001   -24.28295 1.000 8.98309  ? 164 HIS   A ND1 1 
ATOM   638  C  CD2 . HIS   A 1 164 ? -19.35037 5.41306   -26.08625 1.000 7.53199  ? 164 HIS   A CD2 1 
ATOM   639  C  CE1 . HIS   A 1 164 ? -18.64650 3.48435   -25.31723 1.000 6.74717  ? 164 HIS   A CE1 1 
ATOM   640  N  NE2 . HIS   A 1 164 ? -18.91833 4.15244   -26.42357 1.000 7.47150  ? 164 HIS   A NE2 1 
ATOM   641  N  N   . ALA   A 1 165 ? -17.28307 8.45336   -24.49003 1.000 8.01705  ? 165 ALA   A N   1 
ATOM   642  C  CA  . ALA   A 1 165 ? -16.14755 8.77552   -25.35247 1.000 9.51532  ? 165 ALA   A CA  1 
ATOM   643  C  C   . ALA   A 1 165 ? -14.86611 8.90244   -24.54469 1.000 9.99272  ? 165 ALA   A C   1 
ATOM   644  O  O   . ALA   A 1 165 ? -13.80476 8.41228   -24.94946 1.000 9.64030  ? 165 ALA   A O   1 
ATOM   645  C  CB  . ALA   A 1 165 ? -16.41122 10.07743  -26.11411 1.000 6.93023  ? 165 ALA   A CB  1 
ATOM   646  N  N   . ALA   A 1 166 ? -14.94421 9.60150   -23.41380 1.000 12.77041 ? 166 ALA   A N   1 
ATOM   647  C  CA  . ALA   A 1 166 ? -13.78484 9.74554   -22.54857 1.000 11.32788 ? 166 ALA   A CA  1 
ATOM   648  C  C   . ALA   A 1 166 ? -13.26429 8.38166   -22.12888 1.000 13.74521 ? 166 ALA   A C   1 
ATOM   649  O  O   . ALA   A 1 166 ? -12.04581 8.13655   -22.12410 1.000 11.57934 ? 166 ALA   A O   1 
ATOM   650  C  CB  . ALA   A 1 166 ? -14.16312 10.59022  -21.33565 1.000 9.66273  ? 166 ALA   A CB  1 
ATOM   651  N  N   . ASP   A 1 167 ? -14.18609 7.47292   -21.81087 1.000 8.19131  ? 167 ASP   A N   1 
ATOM   652  C  CA  . ASP   A 1 167 ? -13.81878 6.15825   -21.30700 1.000 9.74608  ? 167 ASP   A CA  1 
ATOM   653  C  C   . ASP   A 1 167 ? -13.21830 5.28712   -22.40839 1.000 8.86665  ? 167 ASP   A C   1 
ATOM   654  O  O   . ASP   A 1 167 ? -12.28143 4.52231   -22.14541 1.000 9.55711  ? 167 ASP   A O   1 
ATOM   655  C  CB  . ASP   A 1 167 ? -15.05442 5.52895   -20.66225 1.000 13.70490 ? 167 ASP   A CB  1 
ATOM   656  C  CG  . ASP   A 1 167 ? -14.85952 4.07825   -20.26274 1.000 13.81879 ? 167 ASP   A CG  1 
ATOM   657  O  OD1 . ASP   A 1 167 ? -13.93111 3.77007   -19.48691 1.000 8.96394  ? 167 ASP   A OD1 1 
ATOM   658  O  OD2 . ASP   A 1 167 ? -15.68253 3.24887   -20.70992 1.000 15.79427 ? 167 ASP   A OD2 1 
ATOM   659  N  N   . VAL   A 1 168 ? -13.68823 5.43628   -23.64736 1.000 5.30666  ? 168 VAL   A N   1 
ATOM   660  C  CA  . VAL   A 1 168 ? -13.11347 4.66757   -24.75028 1.000 8.69318  ? 168 VAL   A CA  1 
ATOM   661  C  C   . VAL   A 1 168 ? -11.72906 5.19522   -25.11662 1.000 9.39274  ? 168 VAL   A C   1 
ATOM   662  O  O   . VAL   A 1 168 ? -10.80333 4.40773   -25.37062 1.000 8.41095  ? 168 VAL   A O   1 
ATOM   663  C  CB  . VAL   A 1 168 ? -14.08939 4.65717   -25.93992 1.000 7.50182  ? 168 VAL   A CB  1 
ATOM   664  C  CG1 . VAL   A 1 168 ? -13.46186 4.03952   -27.18407 1.000 7.54636  ? 168 VAL   A CG1 1 
ATOM   665  C  CG2 . VAL   A 1 168 ? -15.35651 3.86362   -25.52502 1.000 8.16613  ? 168 VAL   A CG2 1 
ATOM   666  N  N   . VAL   A 1 169 ? -11.55744 6.52737   -25.11309 1.000 9.66502  ? 169 VAL   A N   1 
ATOM   667  C  CA  . VAL   A 1 169 ? -10.23313 7.13986   -25.26497 1.000 8.86590  ? 169 VAL   A CA  1 
ATOM   668  C  C   . VAL   A 1 169 ? -9.27477  6.63173   -24.19610 1.000 9.66341  ? 169 VAL   A C   1 
ATOM   669  O  O   . VAL   A 1 169 ? -8.10994  6.33378   -24.46860 1.000 13.60187 ? 169 VAL   A O   1 
ATOM   670  C  CB  . VAL   A 1 169 ? -10.32582 8.67637   -25.18217 1.000 12.51925 ? 169 VAL   A CB  1 
ATOM   671  C  CG1 . VAL   A 1 169 ? -8.93096  9.27915   -25.16401 1.000 12.08673 ? 169 VAL   A CG1 1 
ATOM   672  C  CG2 . VAL   A 1 169 ? -11.13065 9.23640   -26.27486 1.000 7.74695  ? 169 VAL   A CG2 1 
ATOM   673  N  N   . GLN   A 1 170 ? -9.72153  6.61002   -22.94963 1.000 10.57063 ? 170 GLN   A N   1 
ATOM   674  C  CA  . GLN   A 1 170 ? -8.79446  6.27986   -21.88195 1.000 10.37174 ? 170 GLN   A CA  1 
ATOM   675  C  C   . GLN   A 1 170 ? -8.48366  4.78594   -21.87984 1.000 10.70546 ? 170 GLN   A C   1 
ATOM   676  O  O   . GLN   A 1 170 ? -7.32900  4.38782   -21.67286 1.000 8.74116  ? 170 GLN   A O   1 
ATOM   677  C  CB  . GLN   A 1 170 ? -9.35981  6.75913   -20.53924 1.000 11.13839 ? 170 GLN   A CB  1 
ATOM   678  C  CG  . GLN   A 1 170 ? -8.39434  6.68122   -19.35951 1.000 9.51842  ? 170 GLN   A CG  1 
ATOM   679  C  CD  . GLN   A 1 170 ? -8.51673  5.38966   -18.57273 1.000 11.39797 ? 170 GLN   A CD  1 
ATOM   680  O  OE1 . GLN   A 1 170 ? -9.57646  4.75662   -18.56396 1.000 10.68490 ? 170 GLN   A OE1 1 
ATOM   681  N  NE2 . GLN   A 1 170 ? -7.43192  4.99277   -17.90108 1.000 8.62962  ? 170 GLN   A NE2 1 
ATOM   682  N  N   . SER   A 1 171 ? -9.49023  3.95097   -22.15124 1.000 8.53095  ? 171 SER   A N   1 
ATOM   683  C  CA  . SER   A 1 171 ? -9.24465  2.51896   -22.28408 1.000 9.16243  ? 171 SER   A CA  1 
ATOM   684  C  C   . SER   A 1 171 ? -8.30579  2.21261   -23.45402 1.000 12.85894 ? 171 SER   A C   1 
ATOM   685  O  O   . SER   A 1 171 ? -7.38433  1.39401   -23.32350 1.000 12.49360 ? 171 SER   A O   1 
ATOM   686  C  CB  . SER   A 1 171 ? -10.57877 1.79054   -22.43661 1.000 9.33139  ? 171 SER   A CB  1 
ATOM   687  O  OG  . SER   A 1 171 ? -11.44887 2.15007   -21.36543 1.000 11.71054 ? 171 SER   A OG  1 
ATOM   688  N  N   . THR   A 1 172 ? -8.52711  2.85012   -24.61112 1.000 11.02710 ? 172 THR   A N   1 
ATOM   689  C  CA  . THR   A 1 172 ? -7.60766  2.67337   -25.73390 1.000 11.25168 ? 172 THR   A CA  1 
ATOM   690  C  C   . THR   A 1 172 ? -6.18084  3.03983   -25.33341 1.000 16.14231 ? 172 THR   A C   1 
ATOM   691  O  O   . THR   A 1 172 ? -5.21532  2.37057   -25.72630 1.000 13.01782 ? 172 THR   A O   1 
ATOM   692  C  CB  . THR   A 1 172 ? -8.05634  3.53176   -26.91579 1.000 12.11123 ? 172 THR   A CB  1 
ATOM   693  O  OG1 . THR   A 1 172 ? -9.18490  2.92458   -27.56942 1.000 11.41255 ? 172 THR   A OG1 1 
ATOM   694  C  CG2 . THR   A 1 172 ? -6.90392  3.74400   -27.92014 1.000 9.34518  ? 172 THR   A CG2 1 
ATOM   695  N  N   . HIS   A 1 173 ? -6.04043  4.09801   -24.53653 1.000 12.80722 ? 173 HIS   A N   1 
ATOM   696  C  CA  . HIS   A 1 173 ? -4.72809  4.55413   -24.11178 1.000 15.74167 ? 173 HIS   A CA  1 
ATOM   697  C  C   . HIS   A 1 173 ? -4.03572  3.51025   -23.24792 1.000 16.05779 ? 173 HIS   A C   1 
ATOM   698  O  O   . HIS   A 1 173 ? -2.82597  3.28921   -23.37187 1.000 15.90092 ? 173 HIS   A O   1 
ATOM   699  C  CB  . HIS   A 1 173 ? -4.87493  5.86687   -23.35374 1.000 12.66703 ? 173 HIS   A CB  1 
ATOM   700  C  CG  . HIS   A 1 173 ? -3.67523  6.21964   -22.54220 1.000 18.92159 ? 173 HIS   A CG  1 
ATOM   701  N  ND1 . HIS   A 1 173 ? -2.54330  6.77544   -23.09535 1.000 17.70578 ? 173 HIS   A ND1 1 
ATOM   702  C  CD2 . HIS   A 1 173 ? -3.42290  6.08441   -21.21869 1.000 19.39171 ? 173 HIS   A CD2 1 
ATOM   703  C  CE1 . HIS   A 1 173 ? -1.64919  6.97997   -22.14593 1.000 16.51248 ? 173 HIS   A CE1 1 
ATOM   704  N  NE2 . HIS   A 1 173 ? -2.16050  6.57514   -20.99817 1.000 16.78841 ? 173 HIS   A NE2 1 
ATOM   705  N  N   . VAL   A 1 174 ? -4.78772  2.86039   -22.36011 1.000 16.26529 ? 174 VAL   A N   1 
ATOM   706  C  CA  . VAL   A 1 174 ? -4.22304  1.76728   -21.58101 1.000 14.92971 ? 174 VAL   A CA  1 
ATOM   707  C  C   . VAL   A 1 174 ? -3.83547  0.60926   -22.48785 1.000 17.03148 ? 174 VAL   A C   1 
ATOM   708  O  O   . VAL   A 1 174 ? -2.77266  0.00135   -22.32178 1.000 16.55013 ? 174 VAL   A O   1 
ATOM   709  C  CB  . VAL   A 1 174 ? -5.20866  1.31824   -20.49290 1.000 16.12259 ? 174 VAL   A CB  1 
ATOM   710  C  CG1 . VAL   A 1 174 ? -4.66164  0.08284   -19.78908 1.000 15.47855 ? 174 VAL   A CG1 1 
ATOM   711  C  CG2 . VAL   A 1 174 ? -5.45166  2.46360   -19.49689 1.000 16.42992 ? 174 VAL   A CG2 1 
ATOM   712  N  N   . LEU   A 1 175 ? -4.69041  0.28007   -23.45676 1.000 13.55415 ? 175 LEU   A N   1 
ATOM   713  C  CA  . LEU   A 1 175 ? -4.38930  -0.86160  -24.30265 1.000 14.02012 ? 175 LEU   A CA  1 
ATOM   714  C  C   . LEU   A 1 175 ? -3.22074  -0.56281  -25.23142 1.000 17.36788 ? 175 LEU   A C   1 
ATOM   715  O  O   . LEU   A 1 175 ? -2.50901  -1.48262  -25.65075 1.000 14.36781 ? 175 LEU   A O   1 
ATOM   716  C  CB  . LEU   A 1 175 ? -5.63480  -1.27195  -25.09187 1.000 12.83947 ? 175 LEU   A CB  1 
ATOM   717  C  CG  . LEU   A 1 175 ? -6.87169  -1.69700  -24.28725 1.000 8.56796  ? 175 LEU   A CG  1 
ATOM   718  C  CD1 . LEU   A 1 175 ? -8.01224  -2.01239  -25.22111 1.000 9.07863  ? 175 LEU   A CD1 1 
ATOM   719  C  CD2 . LEU   A 1 175 ? -6.59549  -2.90503  -23.38873 1.000 12.62968 ? 175 LEU   A CD2 1 
ATOM   720  N  N   . LEU   A 1 176 ? -3.00630  0.70650   -25.56939 1.000 14.96551 ? 176 LEU   A N   1 
ATOM   721  C  CA  . LEU   A 1 176 ? -1.86158  1.03372   -26.41082 1.000 17.66504 ? 176 LEU   A CA  1 
ATOM   722  C  C   . LEU   A 1 176 ? -0.55588  0.78237   -25.68189 1.000 18.24989 ? 176 LEU   A C   1 
ATOM   723  O  O   . LEU   A 1 176 ? 0.45969   0.48464   -26.31458 1.000 16.46287 ? 176 LEU   A O   1 
ATOM   724  C  CB  . LEU   A 1 176 ? -1.91655  2.48813   -26.85698 1.000 11.91269 ? 176 LEU   A CB  1 
ATOM   725  C  CG  . LEU   A 1 176 ? -2.82894  2.82387   -28.01018 1.000 17.85777 ? 176 LEU   A CG  1 
ATOM   726  C  CD1 . LEU   A 1 176 ? -2.97495  4.34801   -28.11043 1.000 13.05264 ? 176 LEU   A CD1 1 
ATOM   727  C  CD2 . LEU   A 1 176 ? -2.28786  2.21095   -29.31939 1.000 19.08887 ? 176 LEU   A CD2 1 
ATOM   728  N  N   . SER   A 1 177 ? -0.56829  0.90032   -24.36160 1.000 19.11585 ? 177 SER   A N   1 
ATOM   729  C  CA  . SER   A 1 177 ? 0.62451   0.78018   -23.54259 1.000 17.36356 ? 177 SER   A CA  1 
ATOM   730  C  C   . SER   A 1 177 ? 0.94409   -0.66000  -23.17992 1.000 24.32398 ? 177 SER   A C   1 
ATOM   731  O  O   . SER   A 1 177 ? 1.92633   -0.90308  -22.46974 1.000 25.67536 ? 177 SER   A O   1 
ATOM   732  C  CB  . SER   A 1 177 ? 0.44528   1.60106   -22.27060 1.000 16.24479 ? 177 SER   A CB  1 
ATOM   733  O  OG  . SER   A 1 177 ? 0.03981   2.91817   -22.60759 1.000 23.65267 ? 177 SER   A OG  1 
ATOM   734  N  N   . THR   A 1 178 ? 0.14095   -1.61331  -23.63746 1.000 18.16122 ? 178 THR   A N   1 
ATOM   735  C  CA  . THR   A 1 178 ? 0.31900   -2.97708  -23.19699 1.000 22.53954 ? 178 THR   A CA  1 
ATOM   736  C  C   . THR   A 1 178 ? 1.70574   -3.47545  -23.63016 1.000 23.25054 ? 178 THR   A C   1 
ATOM   737  O  O   . THR   A 1 178 ? 2.24570   -3.02810  -24.64903 1.000 27.01196 ? 178 THR   A O   1 
ATOM   738  C  CB  . THR   A 1 178 ? -0.83347  -3.83040  -23.73904 1.000 26.64453 ? 178 THR   A CB  1 
ATOM   739  O  OG1 . THR   A 1 178 ? -1.05794  -4.95650  -22.87961 1.000 25.62143 ? 178 THR   A OG1 1 
ATOM   740  C  CG2 . THR   A 1 178 ? -0.58507  -4.28822  -25.16013 1.000 24.98625 ? 178 THR   A CG2 1 
ATOM   741  N  N   . PRO   A 1 179 ? 2.35727   -4.31414  -22.81357 1.000 28.77332 ? 179 PRO   A N   1 
ATOM   742  C  CA  . PRO   A 1 179 ? 3.76109   -4.66900  -23.10967 1.000 23.77326 ? 179 PRO   A CA  1 
ATOM   743  C  C   . PRO   A 1 179 ? 3.95339   -5.40310  -24.42854 1.000 22.99382 ? 179 PRO   A C   1 
ATOM   744  O  O   . PRO   A 1 179 ? 4.90788   -5.10888  -25.15918 1.000 26.03876 ? 179 PRO   A O   1 
ATOM   745  C  CB  . PRO   A 1 179 ? 4.15920   -5.53716  -21.90509 1.000 22.23628 ? 179 PRO   A CB  1 
ATOM   746  C  CG  . PRO   A 1 179 ? 3.27618   -5.08983  -20.81719 1.000 28.13249 ? 179 PRO   A CG  1 
ATOM   747  C  CD  . PRO   A 1 179 ? 1.96998   -4.69755  -21.44250 1.000 26.54745 ? 179 PRO   A CD  1 
ATOM   748  N  N   . ALA   A 1 180 ? 3.06480   -6.33985  -24.77064 1.000 25.42927 ? 180 ALA   A N   1 
ATOM   749  C  CA  . ALA   A 1 180 ? 3.18325   -7.04736  -26.04339 1.000 18.01060 ? 180 ALA   A CA  1 
ATOM   750  C  C   . ALA   A 1 180 ? 3.09116   -6.12255  -27.24613 1.000 27.44393 ? 180 ALA   A C   1 
ATOM   751  O  O   . ALA   A 1 180 ? 3.30147   -6.59268  -28.36908 1.000 26.70980 ? 180 ALA   A O   1 
ATOM   752  C  CB  . ALA   A 1 180 ? 2.11111   -8.13479  -26.17741 1.000 19.28838 ? 180 ALA   A CB  1 
ATOM   753  N  N   . LEU   A 1 181 ? 2.77321   -4.83676  -27.05979 1.000 20.38856 ? 181 LEU   A N   1 
ATOM   754  C  CA  . LEU   A 1 181 ? 2.70401   -3.90940  -28.18287 1.000 27.55393 ? 181 LEU   A CA  1 
ATOM   755  C  C   . LEU   A 1 181 ? 3.81982   -2.87487  -28.16107 1.000 24.45147 ? 181 LEU   A C   1 
ATOM   756  O  O   . LEU   A 1 181 ? 3.81876   -1.96969  -28.99693 1.000 24.23606 ? 181 LEU   A O   1 
ATOM   757  C  CB  . LEU   A 1 181 ? 1.34107   -3.21189  -28.21720 1.000 27.27581 ? 181 LEU   A CB  1 
ATOM   758  C  CG  . LEU   A 1 181 ? 0.18188   -4.15640  -28.55302 1.000 26.20936 ? 181 LEU   A CG  1 
ATOM   759  C  CD1 . LEU   A 1 181 ? -1.14986  -3.39731  -28.56657 1.000 18.98244 ? 181 LEU   A CD1 1 
ATOM   760  C  CD2 . LEU   A 1 181 ? 0.42969   -4.84154  -29.87227 1.000 20.81360 ? 181 LEU   A CD2 1 
ATOM   761  N  N   . GLU   A 1 182 ? 4.77647   -3.00161  -27.24210 1.000 24.64768 ? 182 GLU   A N   1 
ATOM   762  C  CA  . GLU   A 1 182 ? 5.77787   -1.96085  -27.03105 1.000 29.46584 ? 182 GLU   A CA  1 
ATOM   763  C  C   . GLU   A 1 182 ? 6.51582   -1.60811  -28.31583 1.000 26.21108 ? 182 GLU   A C   1 
ATOM   764  O  O   . GLU   A 1 182 ? 6.99268   -2.48368  -29.04908 1.000 23.59693 ? 182 GLU   A O   1 
ATOM   765  C  CB  . GLU   A 1 182 ? 6.77492   -2.39915  -25.96006 1.000 33.13616 ? 182 GLU   A CB  1 
ATOM   766  C  CG  . GLU   A 1 182 ? 7.54240   -1.23145  -25.33658 1.000 45.31012 ? 182 GLU   A CG  1 
ATOM   767  C  CD  . GLU   A 1 182 ? 8.37195   -1.65526  -24.13027 1.000 40.49124 ? 182 GLU   A CD  1 
ATOM   768  O  OE1 . GLU   A 1 182 ? 7.87752   -1.52058  -22.98991 1.000 44.62860 ? 182 GLU   A OE1 1 
ATOM   769  O  OE2 . GLU   A 1 182 ? 9.51193   -2.13276  -24.32081 1.000 44.63631 ? 182 GLU   A OE2 1 
ATOM   770  N  N   . ALA   A 1 183 ? 6.56716   -0.31044  -28.59220 1.000 24.00577 ? 183 ALA   A N   1 
ATOM   771  C  CA  . ALA   A 1 183 ? 7.24846   0.26492   -29.74760 1.000 29.59529 ? 183 ALA   A CA  1 
ATOM   772  C  C   . ALA   A 1 183 ? 6.74193   -0.28298  -31.08399 1.000 27.47732 ? 183 ALA   A C   1 
ATOM   773  O  O   . ALA   A 1 183 ? 7.38602   -0.07002  -32.11761 1.000 28.14709 ? 183 ALA   A O   1 
ATOM   774  C  CB  . ALA   A 1 183 ? 8.76564   0.07747   -29.63461 1.000 34.34868 ? 183 ALA   A CB  1 
ATOM   775  N  N   . VAL   A 1 184 ? 5.58113   -0.95188  -31.10442 1.000 26.54671 ? 184 VAL   A N   1 
ATOM   776  C  CA  . VAL   A 1 184 ? 5.05955   -1.49777  -32.36053 1.000 23.14174 ? 184 VAL   A CA  1 
ATOM   777  C  C   . VAL   A 1 184 ? 4.49475   -0.38947  -33.23205 1.000 24.92487 ? 184 VAL   A C   1 
ATOM   778  O  O   . VAL   A 1 184 ? 4.74305   -0.33963  -34.44232 1.000 29.46704 ? 184 VAL   A O   1 
ATOM   779  C  CB  . VAL   A 1 184 ? 3.99463   -2.57653  -32.09534 1.000 20.52415 ? 184 VAL   A CB  1 
ATOM   780  C  CG1 . VAL   A 1 184 ? 3.10676   -2.76716  -33.30505 1.000 19.82746 ? 184 VAL   A CG1 1 
ATOM   781  C  CG2 . VAL   A 1 184 ? 4.64163   -3.86126  -31.79957 1.000 23.97103 ? 184 VAL   A CG2 1 
ATOM   782  N  N   . PHE   A 1 185 ? 3.70200   0.49312   -32.64477 1.000 19.11296 ? 185 PHE   A N   1 
ATOM   783  C  CA  . PHE   A 1 185 ? 2.94729   1.46109   -33.41886 1.000 17.41007 ? 185 PHE   A CA  1 
ATOM   784  C  C   . PHE   A 1 185 ? 3.68587   2.79033   -33.43724 1.000 16.85394 ? 185 PHE   A C   1 
ATOM   785  O  O   . PHE   A 1 185 ? 4.26738   3.19532   -32.43041 1.000 19.88291 ? 185 PHE   A O   1 
ATOM   786  C  CB  . PHE   A 1 185 ? 1.53290   1.64144   -32.84828 1.000 13.68320 ? 185 PHE   A CB  1 
ATOM   787  C  CG  . PHE   A 1 185 ? 0.64344   0.44465   -33.04979 1.000 17.69233 ? 185 PHE   A CG  1 
ATOM   788  C  CD1 . PHE   A 1 185 ? 0.18678   0.10388   -34.31470 1.000 23.00364 ? 185 PHE   A CD1 1 
ATOM   789  C  CD2 . PHE   A 1 185 ? 0.27121   -0.34470  -31.98114 1.000 13.75789 ? 185 PHE   A CD2 1 
ATOM   790  C  CE1 . PHE   A 1 185 ? -0.61214  -1.01793  -34.49691 1.000 19.60143 ? 185 PHE   A CE1 1 
ATOM   791  C  CE2 . PHE   A 1 185 ? -0.53757  -1.45173  -32.15530 1.000 12.57732 ? 185 PHE   A CE2 1 
ATOM   792  C  CZ  . PHE   A 1 185 ? -0.97770  -1.79455  -33.40410 1.000 12.45222 ? 185 PHE   A CZ  1 
ATOM   793  N  N   . THR   A 1 186 ? 3.67704   3.44984   -34.59499 1.000 15.53487 ? 186 THR   A N   1 
ATOM   794  C  CA  . THR   A 1 186 ? 4.22843   4.78712   -34.70392 1.000 19.50551 ? 186 THR   A CA  1 
ATOM   795  C  C   . THR   A 1 186 ? 3.41204   5.75662   -33.85752 1.000 21.37008 ? 186 THR   A C   1 
ATOM   796  O  O   . THR   A 1 186 ? 2.33930   5.42700   -33.34299 1.000 22.14312 ? 186 THR   A O   1 
ATOM   797  C  CB  . THR   A 1 186 ? 4.20713   5.28758   -36.14864 1.000 18.31132 ? 186 THR   A CB  1 
ATOM   798  O  OG1 . THR   A 1 186 ? 2.86506   5.68046   -36.48949 1.000 18.95688 ? 186 THR   A OG1 1 
ATOM   799  C  CG2 . THR   A 1 186 ? 4.70452   4.21738   -37.12861 1.000 20.38695 ? 186 THR   A CG2 1 
ATOM   800  N  N   . ASP   A 1 187 ? 3.92889   6.98592   -33.74672 1.000 17.94000 ? 187 ASP   A N   1 
ATOM   801  C  CA  . ASP   A 1 187 ? 3.18130   8.05519   -33.09663 1.000 17.93383 ? 187 ASP   A CA  1 
ATOM   802  C  C   . ASP   A 1 187 ? 1.98888   8.49431   -33.92795 1.000 19.82652 ? 187 ASP   A C   1 
ATOM   803  O  O   . ASP   A 1 187 ? 1.01276   9.01976   -33.37855 1.000 14.44212 ? 187 ASP   A O   1 
ATOM   804  C  CB  . ASP   A 1 187 ? 4.07554   9.26056   -32.84349 1.000 25.18806 ? 187 ASP   A CB  1 
ATOM   805  C  CG  . ASP   A 1 187 ? 5.24806   8.93598   -31.96343 1.000 25.64070 ? 187 ASP   A CG  1 
ATOM   806  O  OD1 . ASP   A 1 187 ? 5.10944   8.07256   -31.05171 1.000 22.99269 ? 187 ASP   A OD1 1 
ATOM   807  O  OD2 . ASP   A 1 187 ? 6.30060   9.56172   -32.19811 1.000 18.77823 ? 187 ASP   A OD2 1 
ATOM   808  N  N   . LEU   A 1 188 ? 2.05417   8.32583   -35.25079 1.000 21.32855 ? 188 LEU   A N   1 
ATOM   809  C  CA  . LEU   A 1 188 ? 0.88382   8.65813   -36.04811 1.000 17.55715 ? 188 LEU   A CA  1 
ATOM   810  C  C   . LEU   A 1 188 ? -0.24183  7.66841   -35.77489 1.000 14.77215 ? 188 LEU   A C   1 
ATOM   811  O  O   . LEU   A 1 188 ? -1.40111  8.06392   -35.62742 1.000 12.96327 ? 188 LEU   A O   1 
ATOM   812  C  CB  . LEU   A 1 188 ? 1.24059   8.69466   -37.53202 1.000 15.54942 ? 188 LEU   A CB  1 
ATOM   813  C  CG  . LEU   A 1 188 ? 0.19061   9.40557   -38.40256 1.000 17.26717 ? 188 LEU   A CG  1 
ATOM   814  C  CD1 . LEU   A 1 188 ? 0.10846   10.88588  -38.04893 1.000 19.22387 ? 188 LEU   A CD1 1 
ATOM   815  C  CD2 . LEU   A 1 188 ? 0.49182   9.25684   -39.86643 1.000 16.27153 ? 188 LEU   A CD2 1 
ATOM   816  N  N   . GLU   A 1 189 ? 0.09311   6.38049   -35.66349 1.000 17.32112 ? 189 GLU   A N   1 
ATOM   817  C  CA  . GLU   A 1 189 ? -0.91580  5.36044   -35.39719 1.000 12.25463 ? 189 GLU   A CA  1 
ATOM   818  C  C   . GLU   A 1 189 ? -1.48404  5.50257   -33.99091 1.000 16.35820 ? 189 GLU   A C   1 
ATOM   819  O  O   . GLU   A 1 189 ? -2.69410  5.33090   -33.77592 1.000 14.03123 ? 189 GLU   A O   1 
ATOM   820  C  CB  . GLU   A 1 189 ? -0.30523  3.97419   -35.59430 1.000 16.17679 ? 189 GLU   A CB  1 
ATOM   821  C  CG  . GLU   A 1 189 ? 0.13607   3.67294   -37.03256 1.000 16.41688 ? 189 GLU   A CG  1 
ATOM   822  C  CD  . GLU   A 1 189 ? 1.12863   2.53462   -37.10368 1.000 15.01394 ? 189 GLU   A CD  1 
ATOM   823  O  OE1 . GLU   A 1 189 ? 1.98806   2.43678   -36.21292 1.000 21.15152 ? 189 GLU   A OE1 1 
ATOM   824  O  OE2 . GLU   A 1 189 ? 1.05623   1.72238   -38.03835 1.000 14.75524 ? 189 GLU   A OE2 1 
ATOM   825  N  N   . ILE   A 1 190 ? -0.62276  5.79885   -33.01669 1.000 13.56841 ? 190 ILE   A N   1 
ATOM   826  C  CA  . ILE   A 1 190 ? -1.10428  6.08351   -31.67468 1.000 15.15990 ? 190 ILE   A CA  1 
ATOM   827  C  C   . ILE   A 1 190 ? -2.08015  7.25077   -31.70627 1.000 14.43234 ? 190 ILE   A C   1 
ATOM   828  O  O   . ILE   A 1 190 ? -3.15762  7.19312   -31.09903 1.000 11.83863 ? 190 ILE   A O   1 
ATOM   829  C  CB  . ILE   A 1 190 ? 0.08132   6.34986   -30.72920 1.000 19.34273 ? 190 ILE   A CB  1 
ATOM   830  C  CG1 . ILE   A 1 190 ? 0.72619   5.02594   -30.32230 1.000 18.12860 ? 190 ILE   A CG1 1 
ATOM   831  C  CG2 . ILE   A 1 190 ? -0.38366  7.17025   -29.54034 1.000 13.91710 ? 190 ILE   A CG2 1 
ATOM   832  C  CD1 . ILE   A 1 190 ? 2.13160   5.13012   -29.78603 1.000 16.05515 ? 190 ILE   A CD1 1 
ATOM   833  N  N   . LEU   A 1 191 ? -1.75635  8.29859   -32.47491 1.000 10.03468 ? 191 LEU   A N   1 
ATOM   834  C  CA  . LEU   A 1 191 ? -2.66252  9.44061   -32.54458 1.000 15.27756 ? 191 LEU   A CA  1 
ATOM   835  C  C   . LEU   A 1 191 ? -3.95100  9.08452   -33.28097 1.000 13.60462 ? 191 LEU   A C   1 
ATOM   836  O  O   . LEU   A 1 191 ? -5.04198  9.51179   -32.87881 1.000 17.77865 ? 191 LEU   A O   1 
ATOM   837  C  CB  . LEU   A 1 191 ? -1.96762  10.63012  -33.20838 1.000 15.64259 ? 191 LEU   A CB  1 
ATOM   838  C  CG  . LEU   A 1 191 ? -2.82874  11.86409  -33.49518 1.000 13.36664 ? 191 LEU   A CG  1 
ATOM   839  C  CD1 . LEU   A 1 191 ? -3.01438  12.66939  -32.23118 1.000 14.76991 ? 191 LEU   A CD1 1 
ATOM   840  C  CD2 . LEU   A 1 191 ? -2.18408  12.72254  -34.56318 1.000 17.67684 ? 191 LEU   A CD2 1 
ATOM   841  N  N   . ALA   A 1 192 ? -3.84260  8.32150   -34.37001 1.000 13.52466 ? 192 ALA   A N   1 
ATOM   842  C  CA  . ALA   A 1 192 ? -5.02747  7.86180   -35.08630 1.000 12.76355 ? 192 ALA   A CA  1 
ATOM   843  C  C   . ALA   A 1 192 ? -5.97752  7.11818   -34.15693 1.000 11.70881 ? 192 ALA   A C   1 
ATOM   844  O  O   . ALA   A 1 192 ? -7.18412  7.36554   -34.15764 1.000 12.61930 ? 192 ALA   A O   1 
ATOM   845  C  CB  . ALA   A 1 192 ? -4.61525  6.96364   -36.25394 1.000 12.21118 ? 192 ALA   A CB  1 
ATOM   846  N  N   . ALA   A 1 193 ? -5.43994  6.21383   -33.34068 1.000 10.33785 ? 193 ALA   A N   1 
ATOM   847  C  CA  . ALA   A 1 193 ? -6.28357  5.41449   -32.47026 1.000 9.16553  ? 193 ALA   A CA  1 
ATOM   848  C  C   . ALA   A 1 193 ? -6.95651  6.28546   -31.42948 1.000 11.49040 ? 193 ALA   A C   1 
ATOM   849  O  O   . ALA   A 1 193 ? -8.17706  6.23781   -31.26706 1.000 12.77554 ? 193 ALA   A O   1 
ATOM   850  C  CB  . ALA   A 1 193 ? -5.47271  4.30751   -31.81103 1.000 9.36685  ? 193 ALA   A CB  1 
ATOM   851  N  N   . ILE   A 1 194 ? -6.17560  7.10267   -30.72570 1.000 10.79952 ? 194 ILE   A N   1 
ATOM   852  C  CA  . ILE   A 1 194 ? -6.73910  7.97423   -29.69813 1.000 11.32412 ? 194 ILE   A CA  1 
ATOM   853  C  C   . ILE   A 1 194 ? -7.76775  8.93632   -30.30603 1.000 11.67542 ? 194 ILE   A C   1 
ATOM   854  O  O   . ILE   A 1 194 ? -8.88848  9.07202   -29.80555 1.000 8.46267  ? 194 ILE   A O   1 
ATOM   855  C  CB  . ILE   A 1 194 ? -5.59967  8.69623   -28.96077 1.000 9.46434  ? 194 ILE   A CB  1 
ATOM   856  C  CG1 . ILE   A 1 194 ? -4.76297  7.65014   -28.22895 1.000 13.40879 ? 194 ILE   A CG1 1 
ATOM   857  C  CG2 . ILE   A 1 194 ? -6.11669  9.72135   -27.97085 1.000 9.99203  ? 194 ILE   A CG2 1 
ATOM   858  C  CD1 . ILE   A 1 194 ? -3.39568  8.15692   -27.76739 1.000 14.13198 ? 194 ILE   A CD1 1 
ATOM   859  N  N   . PHE   A 1 195 ? -7.43206  9.56074   -31.43312 1.000 9.81097  ? 195 PHE   A N   1 
ATOM   860  C  CA  . PHE   A 1 195 ? -8.39473  10.42876  -32.09758 1.000 7.03224  ? 195 PHE   A CA  1 
ATOM   861  C  C   . PHE   A 1 195 ? -9.66329  9.67439   -32.48525 1.000 10.60075 ? 195 PHE   A C   1 
ATOM   862  O  O   . PHE   A 1 195 ? -10.77835 10.15392  -32.25076 1.000 8.23439  ? 195 PHE   A O   1 
ATOM   863  C  CB  . PHE   A 1 195 ? -7.77403  11.05568  -33.33845 1.000 9.60737  ? 195 PHE   A CB  1 
ATOM   864  C  CG  . PHE   A 1 195 ? -8.69213  12.00871  -34.04726 1.000 8.63397  ? 195 PHE   A CG  1 
ATOM   865  C  CD1 . PHE   A 1 195 ? -8.94923  13.26695  -33.51024 1.000 10.35612 ? 195 PHE   A CD1 1 
ATOM   866  C  CD2 . PHE   A 1 195 ? -9.28984  11.65870  -35.24144 1.000 8.96142  ? 195 PHE   A CD2 1 
ATOM   867  C  CE1 . PHE   A 1 195 ? -9.78343  14.15870  -34.15526 1.000 10.48501 ? 195 PHE   A CE1 1 
ATOM   868  C  CE2 . PHE   A 1 195 ? -10.11372 12.54774  -35.90627 1.000 10.69206 ? 195 PHE   A CE2 1 
ATOM   869  C  CZ  . PHE   A 1 195 ? -10.37019 13.80001  -35.35620 1.000 12.11988 ? 195 PHE   A CZ  1 
ATOM   870  N  N   . ALA   A 1 196 ? -9.50887  8.51621   -33.13721 1.000 8.47145  ? 196 ALA   A N   1 
ATOM   871  C  CA  . ALA   A 1 196 ? -10.65735 7.68603   -33.48495 1.000 9.37647  ? 196 ALA   A CA  1 
ATOM   872  C  C   . ALA   A 1 196 ? -11.54320 7.40641   -32.27151 1.000 7.27302  ? 196 ALA   A C   1 
ATOM   873  O  O   . ALA   A 1 196 ? -12.76170 7.55990   -32.33954 1.000 7.78679  ? 196 ALA   A O   1 
ATOM   874  C  CB  . ALA   A 1 196 ? -10.18275 6.37602   -34.12340 1.000 7.17442  ? 196 ALA   A CB  1 
ATOM   875  N  N   . SER   A 1 197 ? -10.94159 7.01410   -31.14704 1.000 9.44768  ? 197 SER   A N   1 
ATOM   876  C  CA  . SER   A 1 197 ? -11.71291 6.77237   -29.92416 1.000 12.62620 ? 197 SER   A CA  1 
ATOM   877  C  C   . SER   A 1 197 ? -12.50960 8.00084   -29.51713 1.000 9.57253  ? 197 SER   A C   1 
ATOM   878  O  O   . SER   A 1 197 ? -13.69541 7.89907   -29.17646 1.000 12.04560 ? 197 SER   A O   1 
ATOM   879  C  CB  . SER   A 1 197 ? -10.79176 6.36302   -28.77229 1.000 11.12044 ? 197 SER   A CB  1 
ATOM   880  O  OG  . SER   A 1 197 ? -10.07465 5.18657   -29.07867 1.000 14.67260 ? 197 SER   A OG  1 
ATOM   881  N  N   . ALA   A 1 198 ? -11.86401 9.17022   -29.53182 1.000 9.33006  ? 198 ALA   A N   1 
ATOM   882  C  CA  . ALA   A 1 198 ? -12.50969 10.39380  -29.06969 1.000 9.27137  ? 198 ALA   A CA  1 
ATOM   883  C  C   . ALA   A 1 198 ? -13.75286 10.72319  -29.87964 1.000 9.59018  ? 198 ALA   A C   1 
ATOM   884  O  O   . ALA   A 1 198 ? -14.76733 11.13994  -29.31836 1.000 7.97372  ? 198 ALA   A O   1 
ATOM   885  C  CB  . ALA   A 1 198 ? -11.52141 11.56378  -29.12580 1.000 8.42743  ? 198 ALA   A CB  1 
ATOM   886  N  N   . ILE   A 1 199 ? -13.67744 10.59705  -31.20960 1.000 8.87436  ? 199 ILE   A N   1 
ATOM   887  C  CA  . ILE   A 1 199 ? -14.79350 10.96362  -32.06721 1.000 6.92884  ? 199 ILE   A CA  1 
ATOM   888  C  C   . ILE   A 1 199 ? -15.76972 9.81403   -32.30674 1.000 10.02737 ? 199 ILE   A C   1 
ATOM   889  O  O   . ILE   A 1 199 ? -16.76734 10.00638  -33.01677 1.000 7.59653  ? 199 ILE   A O   1 
ATOM   890  C  CB  . ILE   A 1 199 ? -14.29244 11.45537  -33.43993 1.000 7.69232  ? 199 ILE   A CB  1 
ATOM   891  C  CG1 . ILE   A 1 199 ? -13.67631 10.30355  -34.23598 1.000 6.97716  ? 199 ILE   A CG1 1 
ATOM   892  C  CG2 . ILE   A 1 199 ? -13.28505 12.62253  -33.28932 1.000 8.03809  ? 199 ILE   A CG2 1 
ATOM   893  C  CD1 . ILE   A 1 199 ? -13.50070 10.61275  -35.74651 1.000 7.29686  ? 199 ILE   A CD1 1 
ATOM   894  N  N   . HIS   A 1 200 ? -15.49826 8.61020   -31.77683 1.000 6.86318  ? 200 HIS   A N   1 
ATOM   895  C  CA  . HIS   A 1 200 ? -16.06889 7.43119   -32.42250 1.000 6.03752  ? 200 HIS   A CA  1 
ATOM   896  C  C   . HIS   A 1 200 ? -17.57905 7.34351   -32.27725 1.000 7.32644  ? 200 HIS   A C   1 
ATOM   897  O  O   . HIS   A 1 200 ? -18.21462 6.62144   -33.04919 1.000 7.04595  ? 200 HIS   A O   1 
ATOM   898  C  CB  . HIS   A 1 200 ? -15.42872 6.15354   -31.90169 1.000 7.11429  ? 200 HIS   A CB  1 
ATOM   899  C  CG  . HIS   A 1 200 ? -16.11921 5.58459   -30.70360 1.000 9.87784  ? 200 HIS   A CG  1 
ATOM   900  N  ND1 . HIS   A 1 200 ? -15.90623 6.06263   -29.43058 1.000 6.99302  ? 200 HIS   A ND1 1 
ATOM   901  C  CD2 . HIS   A 1 200 ? -17.02111 4.57677   -30.58472 1.000 6.14265  ? 200 HIS   A CD2 1 
ATOM   902  C  CE1 . HIS   A 1 200 ? -16.65118 5.37388   -28.57435 1.000 8.77949  ? 200 HIS   A CE1 1 
ATOM   903  N  NE2 . HIS   A 1 200 ? -17.33581 4.46820   -29.24889 1.000 7.86910  ? 200 HIS   A NE2 1 
ATOM   904  N  N   . ASP   A 1 201 ? -18.18008 8.07995   -31.34034 1.000 8.07558  ? 201 ASP   A N   1 
ATOM   905  C  CA  . ASP   A 1 201 ? -19.62905 8.05553   -31.18212 1.000 6.82651  ? 201 ASP   A CA  1 
ATOM   906  C  C   . ASP   A 1 201 ? -20.21210 9.46212   -31.19014 1.000 9.31520  ? 201 ASP   A C   1 
ATOM   907  O  O   . ASP   A 1 201 ? -21.36621 9.64756   -30.78479 1.000 8.19773  ? 201 ASP   A O   1 
ATOM   908  C  CB  . ASP   A 1 201 ? -20.03672 7.31958   -29.89196 1.000 8.92595  ? 201 ASP   A CB  1 
ATOM   909  C  CG  . ASP   A 1 201 ? -20.23357 5.79564   -30.08321 1.000 6.22291  ? 201 ASP   A CG  1 
ATOM   910  O  OD1 . ASP   A 1 201 ? -20.55310 5.36104   -31.19471 1.000 4.60903  ? 201 ASP   A OD1 1 
ATOM   911  O  OD2 . ASP   A 1 201 ? -20.10222 5.04013   -29.08592 1.000 6.88639  ? 201 ASP   A OD2 1 
ATOM   912  N  N   . VAL   A 1 202 ? -19.45683 10.45622  -31.67473 1.000 8.29077  ? 202 VAL   A N   1 
ATOM   913  C  CA  . VAL   A 1 202 ? -19.90306 11.83699  -31.54427 1.000 11.37605 ? 202 VAL   A CA  1 
ATOM   914  C  C   . VAL   A 1 202 ? -21.22796 12.05168  -32.27199 1.000 12.78417 ? 202 VAL   A C   1 
ATOM   915  O  O   . VAL   A 1 202 ? -21.48736 11.47366  -33.34128 1.000 14.42673 ? 202 VAL   A O   1 
ATOM   916  C  CB  . VAL   A 1 202 ? -18.82461 12.81462  -32.03770 1.000 12.99108 ? 202 VAL   A CB  1 
ATOM   917  C  CG1 . VAL   A 1 202 ? -18.57377 12.63190  -33.51838 1.000 7.52647  ? 202 VAL   A CG1 1 
ATOM   918  C  CG2 . VAL   A 1 202 ? -19.26603 14.23490  -31.73535 1.000 7.77300  ? 202 VAL   A CG2 1 
ATOM   919  N  N   . ASP   A 1 203 ? -22.09382 12.86791  -31.65779 1.000 12.19376 ? 203 ASP   A N   1 
ATOM   920  C  CA  . ASP   A 1 203 ? -23.43143 13.16660  -32.16160 1.000 10.84676 ? 203 ASP   A CA  1 
ATOM   921  C  C   . ASP   A 1 203 ? -24.29482 11.91507  -32.24298 1.000 9.79846  ? 203 ASP   A C   1 
ATOM   922  O  O   . ASP   A 1 203 ? -25.14314 11.78363  -33.13527 1.000 9.69808  ? 203 ASP   A O   1 
ATOM   923  C  CB  . ASP   A 1 203 ? -23.39233 13.87396  -33.51987 1.000 9.08020  ? 203 ASP   A CB  1 
ATOM   924  C  CG  . ASP   A 1 203 ? -24.67906 14.67482  -33.79887 1.000 13.21009 ? 203 ASP   A CG  1 
ATOM   925  O  OD1 . ASP   A 1 203 ? -25.29014 15.17996  -32.82822 1.000 13.91768 ? 203 ASP   A OD1 1 
ATOM   926  O  OD2 . ASP   A 1 203 ? -25.07730 14.80184  -34.97204 1.000 11.76218 ? 203 ASP   A OD2 1 
ATOM   927  N  N   . HIS   A 1 204 ? -24.06455 10.98820  -31.33953 1.000 9.07740  ? 204 HIS   A N   1 
ATOM   928  C  CA  . HIS   A 1 204 ? -24.90597 9.80442   -31.26934 1.000 10.72691 ? 204 HIS   A CA  1 
ATOM   929  C  C   . HIS   A 1 204 ? -26.27844 10.22568  -30.75745 1.000 11.24281 ? 204 HIS   A C   1 
ATOM   930  O  O   . HIS   A 1 204 ? -26.35561 10.89201  -29.72707 1.000 15.40375 ? 204 HIS   A O   1 
ATOM   931  C  CB  . HIS   A 1 204 ? -24.28042 8.76116   -30.34449 1.000 8.11503  ? 204 HIS   A CB  1 
ATOM   932  C  CG  . HIS   A 1 204 ? -24.81369 7.37914   -30.54823 1.000 11.50068 ? 204 HIS   A CG  1 
ATOM   933  N  ND1 . HIS   A 1 204 ? -26.13262 7.05746   -30.32071 1.000 8.82257  ? 204 HIS   A ND1 1 
ATOM   934  C  CD2 . HIS   A 1 204 ? -24.20812 6.23344   -30.94941 1.000 9.09403  ? 204 HIS   A CD2 1 
ATOM   935  C  CE1 . HIS   A 1 204 ? -26.31925 5.77307   -30.57583 1.000 11.63098 ? 204 HIS   A CE1 1 
ATOM   936  N  NE2 . HIS   A 1 204 ? -25.16934 5.24831   -30.95702 1.000 11.41453 ? 204 HIS   A NE2 1 
ATOM   937  N  N   . PRO   A 1 205 ? -27.36880 9.90189   -31.45491 1.000 9.90615  ? 205 PRO   A N   1 
ATOM   938  C  CA  . PRO   A 1 205 ? -28.69960 10.31149  -30.99252 1.000 12.17623 ? 205 PRO   A CA  1 
ATOM   939  C  C   . PRO   A 1 205 ? -29.32673 9.37418   -29.97549 1.000 15.16700 ? 205 PRO   A C   1 
ATOM   940  O  O   . PRO   A 1 205 ? -30.48307 9.58866   -29.60437 1.000 16.25920 ? 205 PRO   A O   1 
ATOM   941  C  CB  . PRO   A 1 205 ? -29.52260 10.31832  -32.28700 1.000 12.88467 ? 205 PRO   A CB  1 
ATOM   942  C  CG  . PRO   A 1 205 ? -28.89596 9.20028   -33.08569 1.000 14.01409 ? 205 PRO   A CG  1 
ATOM   943  C  CD  . PRO   A 1 205 ? -27.42137 9.23491   -32.76757 1.000 10.55763 ? 205 PRO   A CD  1 
ATOM   944  N  N   . GLY   A 1 206 ? -28.60714 8.34998   -29.52570 1.000 13.17348 ? 206 GLY   A N   1 
ATOM   945  C  CA  . GLY   A 1 206 ? -29.13677 7.45645   -28.51817 1.000 15.80635 ? 206 GLY   A CA  1 
ATOM   946  C  C   . GLY   A 1 206 ? -30.06874 6.38068   -29.03058 1.000 14.86940 ? 206 GLY   A C   1 
ATOM   947  O  O   . GLY   A 1 206 ? -30.80776 5.79803   -28.24090 1.000 15.88830 ? 206 GLY   A O   1 
ATOM   948  N  N   . VAL   A 1 207 ? -30.05676 6.09570   -30.32786 1.000 11.33278 ? 207 VAL   A N   1 
ATOM   949  C  CA  . VAL   A 1 207 ? -30.80162 4.98460   -30.90636 1.000 13.26990 ? 207 VAL   A CA  1 
ATOM   950  C  C   . VAL   A 1 207 ? -29.88082 4.25957   -31.87203 1.000 15.76587 ? 207 VAL   A C   1 
ATOM   951  O  O   . VAL   A 1 207 ? -28.95043 4.85215   -32.42331 1.000 14.48834 ? 207 VAL   A O   1 
ATOM   952  C  CB  . VAL   A 1 207 ? -32.08291 5.43969   -31.63771 1.000 12.98469 ? 207 VAL   A CB  1 
ATOM   953  C  CG1 . VAL   A 1 207 ? -33.12359 5.91310   -30.64636 1.000 16.77669 ? 207 VAL   A CG1 1 
ATOM   954  C  CG2 . VAL   A 1 207 ? -31.76778 6.52431   -32.64635 1.000 14.07087 ? 207 VAL   A CG2 1 
ATOM   955  N  N   . SER   A 1 208 ? -30.16768 2.97931   -32.09409 1.000 17.09259 ? 208 SER   A N   1 
ATOM   956  C  CA  . SER   A 1 208 ? -29.34623 2.09116   -32.91059 1.000 15.14450 ? 208 SER   A CA  1 
ATOM   957  C  C   . SER   A 1 208 ? -29.44179 2.39601   -34.40668 1.000 13.05213 ? 208 SER   A C   1 
ATOM   958  O  O   . SER   A 1 208 ? -30.38685 3.02624   -34.89252 1.000 13.34475 ? 208 SER   A O   1 
ATOM   959  C  CB  . SER   A 1 208 ? -29.78638 0.65465   -32.70560 1.000 13.96900 ? 208 SER   A CB  1 
ATOM   960  O  OG  . SER   A 1 208 ? -31.09578 0.51504   -33.23472 1.000 16.85409 ? 208 SER   A OG  1 
ATOM   961  N  N   . ASN   A 1 209 ? -28.45152 1.88873   -35.14645 1.000 11.72775 ? 209 ASN   A N   1 
ATOM   962  C  CA  . ASN   A 1 209 ? -28.52087 1.90010   -36.60517 1.000 10.05060 ? 209 ASN   A CA  1 
ATOM   963  C  C   . ASN   A 1 209 ? -29.85134 1.33962   -37.08971 1.000 16.52954 ? 209 ASN   A C   1 
ATOM   964  O  O   . ASN   A 1 209 ? -30.49950 1.91211   -37.97928 1.000 13.51937 ? 209 ASN   A O   1 
ATOM   965  C  CB  . ASN   A 1 209 ? -27.37928 1.07358   -37.20888 1.000 10.19196 ? 209 ASN   A CB  1 
ATOM   966  C  CG  . ASN   A 1 209 ? -26.06740 1.86598   -37.37211 1.000 10.89370 ? 209 ASN   A CG  1 
ATOM   967  O  OD1 . ASN   A 1 209 ? -26.07004 3.07974   -37.49739 1.000 11.47393 ? 209 ASN   A OD1 1 
ATOM   968  N  ND2 . ASN   A 1 209 ? -24.94977 1.15290   -37.38530 1.000 7.61774  ? 209 ASN   A ND2 1 
ATOM   969  N  N   . GLN   A 1 210 ? -30.25610 0.18948   -36.53842 1.000 12.62356 ? 210 GLN   A N   1 
ATOM   970  C  CA  . GLN   A 1 210 ? -31.44382 -0.48576  -37.05723 1.000 15.97479 ? 210 GLN   A CA  1 
ATOM   971  C  C   . GLN   A 1 210 ? -32.67985 0.38891   -36.88167 1.000 14.85203 ? 210 GLN   A C   1 
ATOM   972  O  O   . GLN   A 1 210 ? -33.50000 0.50367   -37.79771 1.000 16.67716 ? 210 GLN   A O   1 
ATOM   973  C  CB  . GLN   A 1 210 ? -31.63304 -1.85247  -36.37798 1.000 18.84286 ? 210 GLN   A CB  1 
ATOM   974  C  CG  . GLN   A 1 210 ? -32.76650 -2.70269  -36.97860 1.000 21.70907 ? 210 GLN   A CG  1 
ATOM   975  C  CD  . GLN   A 1 210 ? -32.60732 -2.92086  -38.49002 1.000 21.02106 ? 210 GLN   A CD  1 
ATOM   976  O  OE1 . GLN   A 1 210 ? -33.45535 -2.50540  -39.28162 1.000 27.53584 ? 210 GLN   A OE1 1 
ATOM   977  N  NE2 . GLN   A 1 210 ? -31.51707 -3.54296  -38.88806 1.000 16.31849 ? 210 GLN   A NE2 1 
ATOM   978  N  N   . PHE   A 1 211 ? -32.81512 1.02984   -35.71825 1.000 15.76143 ? 211 PHE   A N   1 
ATOM   979  C  CA  . PHE   A 1 211 ? -33.91564 1.96796   -35.50555 1.000 16.93329 ? 211 PHE   A CA  1 
ATOM   980  C  C   . PHE   A 1 211 ? -33.90937 3.06806   -36.55884 1.000 19.61394 ? 211 PHE   A C   1 
ATOM   981  O  O   . PHE   A 1 211 ? -34.97006 3.50282   -37.02785 1.000 21.17470 ? 211 PHE   A O   1 
ATOM   982  C  CB  . PHE   A 1 211 ? -33.81876 2.57751   -34.10060 1.000 20.33049 ? 211 PHE   A CB  1 
ATOM   983  C  CG  . PHE   A 1 211 ? -34.79522 3.72500   -33.84577 1.000 17.40994 ? 211 PHE   A CG  1 
ATOM   984  C  CD1 . PHE   A 1 211 ? -34.48204 5.01835   -34.20948 1.000 18.43910 ? 211 PHE   A CD1 1 
ATOM   985  C  CD2 . PHE   A 1 211 ? -36.01996 3.49051   -33.22730 1.000 21.10412 ? 211 PHE   A CD2 1 
ATOM   986  C  CE1 . PHE   A 1 211 ? -35.36902 6.06978   -33.98246 1.000 20.77173 ? 211 PHE   A CE1 1 
ATOM   987  C  CE2 . PHE   A 1 211 ? -36.90238 4.53422   -32.98522 1.000 23.63732 ? 211 PHE   A CE2 1 
ATOM   988  C  CZ  . PHE   A 1 211 ? -36.57512 5.82807   -33.36541 1.000 20.28515 ? 211 PHE   A CZ  1 
ATOM   989  N  N   . LEU   A 1 212 ? -32.71997 3.54765   -36.92596 1.000 18.81168 ? 212 LEU   A N   1 
ATOM   990  C  CA  . LEU   A 1 212 ? -32.63836 4.65570   -37.86623 1.000 14.98557 ? 212 LEU   A CA  1 
ATOM   991  C  C   . LEU   A 1 212 ? -32.92580 4.18288   -39.27794 1.000 12.32436 ? 212 LEU   A C   1 
ATOM   992  O  O   . LEU   A 1 212 ? -33.47448 4.93707   -40.08162 1.000 17.51635 ? 212 LEU   A O   1 
ATOM   993  C  CB  . LEU   A 1 212 ? -31.25644 5.32206   -37.77904 1.000 10.37924 ? 212 LEU   A CB  1 
ATOM   994  C  CG  . LEU   A 1 212 ? -30.82606 6.10585   -36.52210 1.000 9.62198  ? 212 LEU   A CG  1 
ATOM   995  C  CD1 . LEU   A 1 212 ? -29.32755 6.33647   -36.56336 1.000 10.94293 ? 212 LEU   A CD1 1 
ATOM   996  C  CD2 . LEU   A 1 212 ? -31.56517 7.44728   -36.37745 1.000 9.86241  ? 212 LEU   A CD2 1 
ATOM   997  N  N   . ILE   A 1 213 ? -32.53269 2.95130   -39.60099 1.000 13.97692 ? 213 ILE   A N   1 
ATOM   998  C  CA  . ILE   A 1 213 ? -32.95653 2.32160   -40.84673 1.000 14.19017 ? 213 ILE   A CA  1 
ATOM   999  C  C   . ILE   A 1 213 ? -34.46692 2.12124   -40.84906 1.000 16.53799 ? 213 ILE   A C   1 
ATOM   1000 O  O   . ILE   A 1 213 ? -35.13750 2.33635   -41.86231 1.000 13.10776 ? 213 ILE   A O   1 
ATOM   1001 C  CB  . ILE   A 1 213 ? -32.24360 0.97324   -41.03803 1.000 14.92889 ? 213 ILE   A CB  1 
ATOM   1002 C  CG1 . ILE   A 1 213 ? -30.74275 1.16193   -41.26368 1.000 14.80880 ? 213 ILE   A CG1 1 
ATOM   1003 C  CG2 . ILE   A 1 213 ? -32.93938 0.16854   -42.16270 1.000 13.69376 ? 213 ILE   A CG2 1 
ATOM   1004 C  CD1 . ILE   A 1 213 ? -29.96697 -0.08073  -41.08889 1.000 12.43880 ? 213 ILE   A CD1 1 
ATOM   1005 N  N   . ASN   A 1 214 ? -35.01702 1.68467   -39.71472 1.000 19.43930 ? 214 ASN   A N   1 
ATOM   1006 C  CA  . ASN   A 1 214 ? -36.41366 1.27330   -39.65318 1.000 28.22490 ? 214 ASN   A CA  1 
ATOM   1007 C  C   . ASN   A 1 214 ? -37.37684 2.44365   -39.59944 1.000 23.04817 ? 214 ASN   A C   1 
ATOM   1008 O  O   . ASN   A 1 214 ? -38.53400 2.28679   -39.98432 1.000 29.94455 ? 214 ASN   A O   1 
ATOM   1009 C  CB  . ASN   A 1 214 ? -36.64121 0.36227   -38.45156 1.000 20.00391 ? 214 ASN   A CB  1 
ATOM   1010 C  CG  . ASN   A 1 214 ? -36.23718 -1.04610  -38.74281 1.000 23.34203 ? 214 ASN   A CG  1 
ATOM   1011 O  OD1 . ASN   A 1 214 ? -35.94240 -1.37530  -39.89173 1.000 22.67455 ? 214 ASN   A OD1 1 
ATOM   1012 N  ND2 . ASN   A 1 214 ? -36.23225 -1.90034  -37.71873 1.000 22.18601 ? 214 ASN   A ND2 1 
ATOM   1013 N  N   . THR   A 1 215 ? -36.92889 3.61067   -39.15744 1.000 22.42586 ? 215 THR   A N   1 
ATOM   1014 C  CA  . THR   A 1 215 ? -37.77834 4.78532   -39.13995 1.000 21.73761 ? 215 THR   A CA  1 
ATOM   1015 C  C   . THR   A 1 215 ? -37.49346 5.71735   -40.31557 1.000 26.45167 ? 215 THR   A C   1 
ATOM   1016 O  O   . THR   A 1 215 ? -37.90534 6.87773   -40.28562 1.000 22.39797 ? 215 THR   A O   1 
ATOM   1017 C  CB  . THR   A 1 215 ? -37.59890 5.51854   -37.81624 1.000 28.12250 ? 215 THR   A CB  1 
ATOM   1018 O  OG1 . THR   A 1 215 ? -36.21150 5.82156   -37.63384 1.000 21.00063 ? 215 THR   A OG1 1 
ATOM   1019 C  CG2 . THR   A 1 215 ? -38.06116 4.64670   -36.67145 1.000 27.14106 ? 215 THR   A CG2 1 
ATOM   1020 N  N   . ASN   A 1 216 ? -36.77614 5.23399   -41.33769 1.000 26.05446 ? 216 ASN   A N   1 
ATOM   1021 C  CA  . ASN   A 1 216 ? -36.43555 6.01902   -42.53254 1.000 20.35281 ? 216 ASN   A CA  1 
ATOM   1022 C  C   . ASN   A 1 216 ? -35.83971 7.36911   -42.17345 1.000 17.02854 ? 216 ASN   A C   1 
ATOM   1023 O  O   . ASN   A 1 216 ? -36.11531 8.37831   -42.81790 1.000 23.75722 ? 216 ASN   A O   1 
ATOM   1024 C  CB  . ASN   A 1 216 ? -37.64943 6.21279   -43.44282 1.000 30.09316 ? 216 ASN   A CB  1 
ATOM   1025 C  CG  . ASN   A 1 216 ? -38.53454 5.00265   -43.47963 1.000 28.00407 ? 216 ASN   A CG  1 
ATOM   1026 O  OD1 . ASN   A 1 216 ? -38.05763 3.88055   -43.67956 1.000 34.71624 ? 216 ASN   A OD1 1 
ATOM   1027 N  ND2 . ASN   A 1 216 ? -39.83145 5.20657   -43.24283 1.000 31.08614 ? 216 ASN   A ND2 1 
ATOM   1028 N  N   . SER   A 1 217 ? -35.00388 7.38702   -41.14460 1.000 17.09508 ? 217 SER   A N   1 
ATOM   1029 C  CA  . SER   A 1 217 ? -34.32890 8.60833   -40.73218 1.000 14.23170 ? 217 SER   A CA  1 
ATOM   1030 C  C   . SER   A 1 217 ? -33.53338 9.21353   -41.88712 1.000 16.54952 ? 217 SER   A C   1 
ATOM   1031 O  O   . SER   A 1 217 ? -33.14713 8.53301   -42.84633 1.000 20.49550 ? 217 SER   A O   1 
ATOM   1032 C  CB  . SER   A 1 217 ? -33.38226 8.32273   -39.56553 1.000 18.49641 ? 217 SER   A CB  1 
ATOM   1033 O  OG  . SER   A 1 217 ? -32.50330 7.23492   -39.88621 1.000 18.04949 ? 217 SER   A OG  1 
ATOM   1034 N  N   . GLU   A 1 218 ? -33.29274 10.51765  -41.77163 1.000 13.65266 ? 218 GLU   A N   1 
ATOM   1035 C  CA  . GLU   A 1 218 ? -32.39602 11.20907  -42.68185 1.000 19.28736 ? 218 GLU   A CA  1 
ATOM   1036 C  C   . GLU   A 1 218 ? -30.97922 10.61003  -42.65202 1.000 17.01906 ? 218 GLU   A C   1 
ATOM   1037 O  O   . GLU   A 1 218 ? -30.32089 10.50330  -43.68918 1.000 17.29102 ? 218 GLU   A O   1 
ATOM   1038 C  CB  . GLU   A 1 218 ? -32.39590 12.69860  -42.31676 1.000 23.99477 ? 218 GLU   A CB  1 
ATOM   1039 C  CG  . GLU   A 1 218 ? -31.59980 13.60489  -43.24678 1.000 37.47891 ? 218 GLU   A CG  1 
ATOM   1040 C  CD  . GLU   A 1 218 ? -32.08534 13.57039  -44.69936 1.000 42.11442 ? 218 GLU   A CD  1 
ATOM   1041 O  OE1 . GLU   A 1 218 ? -33.20340 14.06892  -44.97148 1.000 38.69975 ? 218 GLU   A OE1 1 
ATOM   1042 O  OE2 . GLU   A 1 218 ? -31.33809 13.04314  -45.56557 1.000 39.05037 ? 218 GLU   A OE2 1 
ATOM   1043 N  N   . LEU   A 1 219 ? -30.49327 10.22055  -41.47250 1.000 15.88835 ? 219 LEU   A N   1 
ATOM   1044 C  CA  . LEU   A 1 219 ? -29.17020 9.61717   -41.37133 1.000 15.90362 ? 219 LEU   A CA  1 
ATOM   1045 C  C   . LEU   A 1 219 ? -29.07944 8.34384   -42.20547 1.000 14.84562 ? 219 LEU   A C   1 
ATOM   1046 O  O   . LEU   A 1 219 ? -28.12989 8.15721   -42.97133 1.000 15.65745 ? 219 LEU   A O   1 
ATOM   1047 C  CB  . LEU   A 1 219 ? -28.83858 9.33224   -39.90118 1.000 15.72776 ? 219 LEU   A CB  1 
ATOM   1048 C  CG  . LEU   A 1 219 ? -28.25874 10.51828  -39.11753 1.000 25.35032 ? 219 LEU   A CG  1 
ATOM   1049 C  CD1 . LEU   A 1 219 ? -28.38283 10.33743  -37.59636 1.000 21.36845 ? 219 LEU   A CD1 1 
ATOM   1050 C  CD2 . LEU   A 1 219 ? -26.80686 10.74002  -39.50041 1.000 19.40916 ? 219 LEU   A CD2 1 
ATOM   1051 N  N   . ALA   A 1 220 ? -30.06437 7.44910   -42.06903 1.000 14.36896 ? 220 ALA   A N   1 
ATOM   1052 C  CA  . ALA   A 1 220 ? -30.04442 6.22000   -42.84972 1.000 12.91047 ? 220 ALA   A CA  1 
ATOM   1053 C  C   . ALA   A 1 220 ? -30.21115 6.50702   -44.32850 1.000 13.83774 ? 220 ALA   A C   1 
ATOM   1054 O  O   . ALA   A 1 220 ? -29.62986 5.80837   -45.16573 1.000 14.88485 ? 220 ALA   A O   1 
ATOM   1055 C  CB  . ALA   A 1 220 ? -31.12823 5.25787   -42.36982 1.000 15.23117 ? 220 ALA   A CB  1 
ATOM   1056 N  N   . LEU   A 1 221 ? -30.97347 7.54304   -44.66259 1.000 17.06331 ? 221 LEU   A N   1 
ATOM   1057 C  CA  . LEU   A 1 221 ? -31.12582 7.93852   -46.05603 1.000 16.09711 ? 221 LEU   A CA  1 
ATOM   1058 C  C   . LEU   A 1 221 ? -29.80825 8.47450   -46.60186 1.000 17.11229 ? 221 LEU   A C   1 
ATOM   1059 O  O   . LEU   A 1 221 ? -29.38670 8.12831   -47.71600 1.000 12.67896 ? 221 LEU   A O   1 
ATOM   1060 C  CB  . LEU   A 1 221 ? -32.23574 8.98829   -46.15596 1.000 17.71012 ? 221 LEU   A CB  1 
ATOM   1061 C  CG  . LEU   A 1 221 ? -32.93277 9.32272   -47.48009 1.000 22.36506 ? 221 LEU   A CG  1 
ATOM   1062 C  CD1 . LEU   A 1 221 ? -32.00741 10.06316  -48.41862 1.000 21.19080 ? 221 LEU   A CD1 1 
ATOM   1063 C  CD2 . LEU   A 1 221 ? -33.48131 8.07459   -48.13458 1.000 22.05588 ? 221 LEU   A CD2 1 
ATOM   1064 N  N   . MET   A 1 222 ? -29.14092 9.31534   -45.80938 1.000 16.38206 ? 222 MET   A N   1 
ATOM   1065 C  CA  . MET   A 1 222 ? -27.84142 9.84532   -46.19234 1.000 15.29790 ? 222 MET   A CA  1 
ATOM   1066 C  C   . MET   A 1 222 ? -26.86717 8.71611   -46.47748 1.000 14.56310 ? 222 MET   A C   1 
ATOM   1067 O  O   . MET   A 1 222 ? -26.15426 8.74026   -47.48387 1.000 14.46563 ? 222 MET   A O   1 
ATOM   1068 C  CB  . MET   A 1 222 ? -27.30437 10.76243  -45.07605 1.000 15.24858 ? 222 MET   A CB  1 
ATOM   1069 C  CG  . MET   A 1 222 ? -25.94978 11.43207  -45.37134 1.000 14.38930 ? 222 MET   A CG  1 
ATOM   1070 S  SD  . MET   A 1 222 ? -26.02894 12.62871  -46.74357 1.000 27.23285 ? 222 MET   A SD  1 
ATOM   1071 C  CE  . MET   A 1 222 ? -26.58013 14.10725  -45.85716 1.000 28.55906 ? 222 MET   A CE  1 
ATOM   1072 N  N   . TYR   A 1 223 ? -26.85163 7.69559   -45.62001 1.000 13.87188 ? 223 TYR   A N   1 
ATOM   1073 C  CA  . TYR   A 1 223 ? -25.79430 6.69443   -45.62754 1.000 9.31494  ? 223 TYR   A CA  1 
ATOM   1074 C  C   . TYR   A 1 223 ? -26.24449 5.34332   -46.17632 1.000 13.38613 ? 223 TYR   A C   1 
ATOM   1075 O  O   . TYR   A 1 223 ? -25.51238 4.35798   -46.04269 1.000 8.65614  ? 223 TYR   A O   1 
ATOM   1076 C  CB  . TYR   A 1 223 ? -25.22158 6.56636   -44.21168 1.000 10.02897 ? 223 TYR   A CB  1 
ATOM   1077 C  CG  . TYR   A 1 223 ? -24.38361 7.78380   -43.84658 1.000 10.66667 ? 223 TYR   A CG  1 
ATOM   1078 C  CD1 . TYR   A 1 223 ? -23.24603 8.08272   -44.57888 1.000 11.14475 ? 223 TYR   A CD1 1 
ATOM   1079 C  CD2 . TYR   A 1 223 ? -24.75344 8.65380   -42.81476 1.000 11.13448 ? 223 TYR   A CD2 1 
ATOM   1080 C  CE1 . TYR   A 1 223 ? -22.47782 9.18602   -44.29140 1.000 15.19612 ? 223 TYR   A CE1 1 
ATOM   1081 C  CE2 . TYR   A 1 223 ? -23.97638 9.79043   -42.51217 1.000 8.55277  ? 223 TYR   A CE2 1 
ATOM   1082 C  CZ  . TYR   A 1 223 ? -22.83289 10.03034  -43.26094 1.000 12.02470 ? 223 TYR   A CZ  1 
ATOM   1083 O  OH  . TYR   A 1 223 ? -22.02113 11.10959  -43.03883 1.000 9.99411  ? 223 TYR   A OH  1 
ATOM   1084 N  N   . ASN   A 1 224 ? -27.42141 5.27013   -46.80158 1.000 9.53614  ? 224 ASN   A N   1 
ATOM   1085 C  CA  . ASN   A 1 224 ? -27.81484 4.06758   -47.53771 1.000 10.08255 ? 224 ASN   A CA  1 
ATOM   1086 C  C   . ASN   A 1 224 ? -27.77683 2.81674   -46.64434 1.000 11.65876 ? 224 ASN   A C   1 
ATOM   1087 O  O   . ASN   A 1 224 ? -27.35102 1.74012   -47.06027 1.000 9.07388  ? 224 ASN   A O   1 
ATOM   1088 C  CB  . ASN   A 1 224 ? -26.92655 3.90657   -48.77859 1.000 11.88012 ? 224 ASN   A CB  1 
ATOM   1089 C  CG  . ASN   A 1 224 ? -26.97102 5.13849   -49.68422 1.000 12.78398 ? 224 ASN   A CG  1 
ATOM   1090 O  OD1 . ASN   A 1 224 ? -28.04599 5.59856   -50.03460 1.000 16.27877 ? 224 ASN   A OD1 1 
ATOM   1091 N  ND2 . ASN   A 1 224 ? -25.81429 5.70619   -50.00756 1.000 7.26478  ? 224 ASN   A ND2 1 
ATOM   1092 N  N   . ASP   A 1 225 ? -28.18072 2.98021   -45.38534 1.000 11.22934 ? 225 ASP   A N   1 
ATOM   1093 C  CA  . ASP   A 1 225 ? -28.38018 1.90757   -44.40621 1.000 11.83713 ? 225 ASP   A CA  1 
ATOM   1094 C  C   . ASP   A 1 225 ? -27.10439 1.18606   -43.94968 1.000 14.30179 ? 225 ASP   A C   1 
ATOM   1095 O  O   . ASP   A 1 225 ? -27.21149 0.21235   -43.19068 1.000 13.35000 ? 225 ASP   A O   1 
ATOM   1096 C  CB  . ASP   A 1 225 ? -29.40718 0.88148   -44.91975 1.000 9.40946  ? 225 ASP   A CB  1 
ATOM   1097 C  CG  . ASP   A 1 225 ? -30.80541 1.48868   -45.07209 1.000 10.48940 ? 225 ASP   A CG  1 
ATOM   1098 O  OD1 . ASP   A 1 225 ? -31.06856 2.52853   -44.43236 1.000 12.81396 ? 225 ASP   A OD1 1 
ATOM   1099 O  OD2 . ASP   A 1 225 ? -31.64605 0.93218   -45.80808 1.000 13.60803 ? 225 ASP   A OD2 1 
ATOM   1100 N  N   . SER   A 1 226 ? -25.90233 1.63958   -44.32922 1.000 11.29393 ? 226 SER   A N   1 
ATOM   1101 C  CA  . SER   A 1 226 ? -24.65910 0.91911   -44.02097 1.000 11.41491 ? 226 SER   A CA  1 
ATOM   1102 C  C   . SER   A 1 226 ? -23.79349 1.73254   -43.05777 1.000 11.73304 ? 226 SER   A C   1 
ATOM   1103 O  O   . SER   A 1 226 ? -23.35553 2.84323   -43.39285 1.000 11.82567 ? 226 SER   A O   1 
ATOM   1104 C  CB  . SER   A 1 226 ? -23.86677 0.61444   -45.29875 1.000 11.28623 ? 226 SER   A CB  1 
ATOM   1105 O  OG  . SER   A 1 226 ? -24.71697 0.20413   -46.37134 1.000 20.42670 ? 226 SER   A OG  1 
ATOM   1106 N  N   . SER   A 1 227 ? -23.54684 1.18218   -41.86935 1.000 10.94166 ? 227 SER   A N   1 
ATOM   1107 C  CA  . SER   A 1 227 ? -22.75489 1.86050   -40.83942 1.000 11.79997 ? 227 SER   A CA  1 
ATOM   1108 C  C   . SER   A 1 227 ? -23.21471 3.31410   -40.66784 1.000 13.44345 ? 227 SER   A C   1 
ATOM   1109 O  O   . SER   A 1 227 ? -22.42494 4.26561   -40.72184 1.000 8.63625  ? 227 SER   A O   1 
ATOM   1110 C  CB  . SER   A 1 227 ? -21.25971 1.78755   -41.17063 1.000 13.62709 ? 227 SER   A CB  1 
ATOM   1111 O  OG  . SER   A 1 227 ? -20.83431 0.44208   -41.31260 1.000 9.25777  ? 227 SER   A OG  1 
ATOM   1112 N  N   . VAL   A 1 228 ? -24.53027 3.47002   -40.47426 1.000 11.72290 ? 228 VAL   A N   1 
ATOM   1113 C  CA  . VAL   A 1 228 ? -25.15803 4.78222   -40.54893 1.000 6.39841  ? 228 VAL   A CA  1 
ATOM   1114 C  C   . VAL   A 1 228 ? -24.55738 5.71556   -39.50916 1.000 9.13964  ? 228 VAL   A C   1 
ATOM   1115 O  O   . VAL   A 1 228 ? -24.08959 6.81367   -39.83132 1.000 7.28089  ? 228 VAL   A O   1 
ATOM   1116 C  CB  . VAL   A 1 228 ? -26.68651 4.64275   -40.38700 1.000 12.25887 ? 228 VAL   A CB  1 
ATOM   1117 C  CG1 . VAL   A 1 228 ? -27.33393 5.99227   -40.09162 1.000 7.77924  ? 228 VAL   A CG1 1 
ATOM   1118 C  CG2 . VAL   A 1 228 ? -27.29043 3.98684   -41.63912 1.000 9.42912  ? 228 VAL   A CG2 1 
ATOM   1119 N  N   . LEU   A 1 229 ? -24.53058 5.27517   -38.25166 1.000 8.17564  ? 229 LEU   A N   1 
ATOM   1120 C  CA  . LEU   A 1 229 ? -23.98490 6.10963   -37.18408 1.000 9.68883  ? 229 LEU   A CA  1 
ATOM   1121 C  C   . LEU   A 1 229 ? -22.48790 6.31469   -37.35445 1.000 9.26176  ? 229 LEU   A C   1 
ATOM   1122 O  O   . LEU   A 1 229 ? -21.96928 7.43312   -37.21417 1.000 10.24734 ? 229 LEU   A O   1 
ATOM   1123 C  CB  . LEU   A 1 229 ? -24.26289 5.45957   -35.83180 1.000 12.03998 ? 229 LEU   A CB  1 
ATOM   1124 C  CG  . LEU   A 1 229 ? -25.70852 5.36633   -35.32791 1.000 13.36525 ? 229 LEU   A CG  1 
ATOM   1125 C  CD1 . LEU   A 1 229 ? -25.87919 4.15940   -34.37015 1.000 14.32006 ? 229 LEU   A CD1 1 
ATOM   1126 C  CD2 . LEU   A 1 229 ? -26.07873 6.65151   -34.63240 1.000 10.12133 ? 229 LEU   A CD2 1 
ATOM   1127 N  N   . GLU   A 1 230 ? -21.77634 5.23174   -37.62264 1.000 6.04928  ? 230 GLU   A N   1 
ATOM   1128 C  CA  . GLU   A 1 230 ? -20.33128 5.29267   -37.64215 1.000 11.85770 ? 230 GLU   A CA  1 
ATOM   1129 C  C   . GLU   A 1 230 ? -19.82818 6.21935   -38.74608 1.000 8.90357  ? 230 GLU   A C   1 
ATOM   1130 O  O   . GLU   A 1 230 ? -18.89315 6.99413   -38.52982 1.000 6.89779  ? 230 GLU   A O   1 
ATOM   1131 C  CB  . GLU   A 1 230 ? -19.79105 3.88009   -37.77916 1.000 8.46456  ? 230 GLU   A CB  1 
ATOM   1132 C  CG  . GLU   A 1 230 ? -20.09273 3.04098   -36.56109 1.000 8.46959  ? 230 GLU   A CG  1 
ATOM   1133 C  CD  . GLU   A 1 230 ? -21.53526 2.51091   -36.49834 1.000 10.64544 ? 230 GLU   A CD  1 
ATOM   1134 O  OE1 . GLU   A 1 230 ? -22.26435 2.49278   -37.51956 1.000 8.20342  ? 230 GLU   A OE1 1 
ATOM   1135 O  OE2 . GLU   A 1 230 ? -21.92124 2.08144   -35.39602 1.000 11.61495 ? 230 GLU   A OE2 1 
ATOM   1136 N  N   . ASN   A 1 231 ? -20.44835 6.16738   -39.92721 1.000 8.38623  ? 231 ASN   A N   1 
ATOM   1137 C  CA  . ASN   A 1 231 ? -20.14474 7.16141   -40.94932 1.000 8.54394  ? 231 ASN   A CA  1 
ATOM   1138 C  C   . ASN   A 1 231 ? -20.38670 8.56285   -40.42682 1.000 10.84050 ? 231 ASN   A C   1 
ATOM   1139 O  O   . ASN   A 1 231 ? -19.56415 9.45352   -40.63502 1.000 6.29681  ? 231 ASN   A O   1 
ATOM   1140 C  CB  . ASN   A 1 231 ? -20.98958 6.92483   -42.19988 1.000 11.07205 ? 231 ASN   A CB  1 
ATOM   1141 C  CG  . ASN   A 1 231 ? -20.38919 5.89501   -43.09726 1.000 14.47032 ? 231 ASN   A CG  1 
ATOM   1142 O  OD1 . ASN   A 1 231 ? -19.32405 6.12305   -43.67158 1.000 15.62471 ? 231 ASN   A OD1 1 
ATOM   1143 N  ND2 . ASN   A 1 231 ? -21.03572 4.73948   -43.20660 1.000 6.91323  ? 231 ASN   A ND2 1 
ATOM   1144 N  N   . HIS   A 1 232 ? -21.52552 8.77333   -39.75355 1.000 9.92061  ? 232 HIS   A N   1 
ATOM   1145 C  CA  . HIS   A 1 232 ? -21.87173 10.09540  -39.24797 1.000 9.90740  ? 232 HIS   A CA  1 
ATOM   1146 C  C   . HIS   A 1 232 ? -20.90298 10.54918  -38.14779 1.000 11.15747 ? 232 HIS   A C   1 
ATOM   1147 O  O   . HIS   A 1 232 ? -20.45439 11.70017  -38.15433 1.000 10.43276 ? 232 HIS   A O   1 
ATOM   1148 C  CB  . HIS   A 1 232 ? -23.31975 10.08673  -38.73146 1.000 11.96200 ? 232 HIS   A CB  1 
ATOM   1149 C  CG  . HIS   A 1 232 ? -23.77476 11.40757  -38.17848 1.000 12.91580 ? 232 HIS   A CG  1 
ATOM   1150 N  ND1 . HIS   A 1 232 ? -23.91026 12.53062  -38.96207 1.000 8.09876  ? 232 HIS   A ND1 1 
ATOM   1151 C  CD2 . HIS   A 1 232 ? -24.13165 11.77970  -36.92293 1.000 11.65201 ? 232 HIS   A CD2 1 
ATOM   1152 C  CE1 . HIS   A 1 232 ? -24.30683 13.54419  -38.21019 1.000 12.44422 ? 232 HIS   A CE1 1 
ATOM   1153 N  NE2 . HIS   A 1 232 ? -24.45921 13.11293  -36.97018 1.000 10.24655 ? 232 HIS   A NE2 1 
ATOM   1154 N  N   . HIS   A 1 233 ? -20.56558 9.67648   -37.18963 1.000 7.57498  ? 233 HIS   A N   1 
ATOM   1155 C  CA  . HIS   A 1 233 ? -19.55463 10.07850  -36.21369 1.000 11.06610 ? 233 HIS   A CA  1 
ATOM   1156 C  C   . HIS   A 1 233 ? -18.27062 10.52109  -36.91928 1.000 10.78321 ? 233 HIS   A C   1 
ATOM   1157 O  O   . HIS   A 1 233 ? -17.65598 11.50994  -36.52589 1.000 7.43937  ? 233 HIS   A O   1 
ATOM   1158 C  CB  . HIS   A 1 233 ? -19.21852 8.96196   -35.21210 1.000 6.84646  ? 233 HIS   A CB  1 
ATOM   1159 C  CG  . HIS   A 1 233 ? -20.40536 8.25245   -34.62330 1.000 10.27659 ? 233 HIS   A CG  1 
ATOM   1160 N  ND1 . HIS   A 1 233 ? -21.50048 8.91386   -34.11742 1.000 9.56110  ? 233 HIS   A ND1 1 
ATOM   1161 C  CD2 . HIS   A 1 233 ? -20.64082 6.92673   -34.42328 1.000 8.03251  ? 233 HIS   A CD2 1 
ATOM   1162 C  CE1 . HIS   A 1 233 ? -22.37110 8.02970   -33.65498 1.000 9.26407  ? 233 HIS   A CE1 1 
ATOM   1163 N  NE2 . HIS   A 1 233 ? -21.86127 6.81888   -33.80701 1.000 11.13699 ? 233 HIS   A NE2 1 
ATOM   1164 N  N   . LEU   A 1 234 ? -17.85707 9.80828   -37.97492 1.000 9.05122  ? 234 LEU   A N   1 
ATOM   1165 C  CA  . LEU   A 1 234 ? -16.66068 10.22038  -38.69852 1.000 9.99098  ? 234 LEU   A CA  1 
ATOM   1166 C  C   . LEU   A 1 234 ? -16.86777 11.57529  -39.35745 1.000 9.44702  ? 234 LEU   A C   1 
ATOM   1167 O  O   . LEU   A 1 234 ? -16.03869 12.47510  -39.22330 1.000 9.79077  ? 234 LEU   A O   1 
ATOM   1168 C  CB  . LEU   A 1 234 ? -16.27276 9.16432   -39.72989 1.000 8.41374  ? 234 LEU   A CB  1 
ATOM   1169 C  CG  . LEU   A 1 234 ? -15.43522 7.96731   -39.24584 1.000 8.79589  ? 234 LEU   A CG  1 
ATOM   1170 C  CD1 . LEU   A 1 234 ? -15.47912 6.78671   -40.23015 1.000 7.11799  ? 234 LEU   A CD1 1 
ATOM   1171 C  CD2 . LEU   A 1 234 ? -14.00501 8.37722   -38.97237 1.000 7.57613  ? 234 LEU   A CD2 1 
ATOM   1172 N  N   . ALA   A 1 235 ? -17.98249 11.74023  -40.04999 1.000 5.85161  ? 235 ALA   A N   1 
ATOM   1173 C  CA  . ALA   A 1 235 ? -18.24080 12.98017  -40.76307 1.000 11.05589 ? 235 ALA   A CA  1 
ATOM   1174 C  C   . ALA   A 1 235 ? -18.18568 14.19098  -39.83659 1.000 11.59126 ? 235 ALA   A C   1 
ATOM   1175 O  O   . ALA   A 1 235 ? -17.68860 15.25831  -40.22759 1.000 12.49022 ? 235 ALA   A O   1 
ATOM   1176 C  CB  . ALA   A 1 235 ? -19.60071 12.89239  -41.45303 1.000 6.17106  ? 235 ALA   A CB  1 
ATOM   1177 N  N   . VAL   A 1 236 ? -18.69044 14.04005  -38.60813 1.000 7.66981  ? 236 VAL   A N   1 
ATOM   1178 C  CA  . VAL   A 1 236 ? -18.73183 15.13613  -37.64878 1.000 7.07881  ? 236 VAL   A CA  1 
ATOM   1179 C  C   . VAL   A 1 236 ? -17.36328 15.33859  -37.02212 1.000 13.07166 ? 236 VAL   A C   1 
ATOM   1180 O  O   . VAL   A 1 236 ? -16.87361 16.47150  -36.94151 1.000 12.31397 ? 236 VAL   A O   1 
ATOM   1181 C  CB  . VAL   A 1 236 ? -19.82430 14.86440  -36.59084 1.000 10.06383 ? 236 VAL   A CB  1 
ATOM   1182 C  CG1 . VAL   A 1 236 ? -19.66797 15.76568  -35.32186 1.000 8.55350  ? 236 VAL   A CG1 1 
ATOM   1183 C  CG2 . VAL   A 1 236 ? -21.24162 14.98407  -37.20472 1.000 10.97207 ? 236 VAL   A CG2 1 
ATOM   1184 N  N   . GLY   A 1 237 ? -16.72681 14.23965  -36.58506 1.000 8.41095  ? 237 GLY   A N   1 
ATOM   1185 C  CA  . GLY   A 1 237 ? -15.39544 14.32647  -35.99967 1.000 7.45140  ? 237 GLY   A CA  1 
ATOM   1186 C  C   . GLY   A 1 237 ? -14.40500 15.11628  -36.84147 1.000 10.91965 ? 237 GLY   A C   1 
ATOM   1187 O  O   . GLY   A 1 237 ? -13.65859 15.94704  -36.31715 1.000 11.32641 ? 237 GLY   A O   1 
ATOM   1188 N  N   . PHE   A 1 238 ? -14.36739 14.84839  -38.15678 1.000 9.64099  ? 238 PHE   A N   1 
ATOM   1189 C  CA  . PHE   A 1 238 ? -13.44427 15.53279  -39.07352 1.000 13.89492 ? 238 PHE   A CA  1 
ATOM   1190 C  C   . PHE   A 1 238 ? -13.89320 16.96277  -39.36535 1.000 11.81357 ? 238 PHE   A C   1 
ATOM   1191 O  O   . PHE   A 1 238 ? -13.06245 17.87742  -39.41456 1.000 15.93918 ? 238 PHE   A O   1 
ATOM   1192 C  CB  . PHE   A 1 238 ? -13.31001 14.76203  -40.40798 1.000 9.42456  ? 238 PHE   A CB  1 
ATOM   1193 C  CG  . PHE   A 1 238 ? -12.50692 13.48921  -40.30848 1.000 10.98074 ? 238 PHE   A CG  1 
ATOM   1194 C  CD1 . PHE   A 1 238 ? -11.14873 13.52439  -40.05017 1.000 13.13158 ? 238 PHE   A CD1 1 
ATOM   1195 C  CD2 . PHE   A 1 238 ? -13.10626 12.25746  -40.48918 1.000 14.14262 ? 238 PHE   A CD2 1 
ATOM   1196 C  CE1 . PHE   A 1 238 ? -10.40257 12.34516  -39.93557 1.000 12.96675 ? 238 PHE   A CE1 1 
ATOM   1197 C  CE2 . PHE   A 1 238 ? -12.36064 11.08331  -40.41408 1.000 14.10656 ? 238 PHE   A CE2 1 
ATOM   1198 C  CZ  . PHE   A 1 238 ? -11.00149 11.13254  -40.12302 1.000 11.23365 ? 238 PHE   A CZ  1 
ATOM   1199 N  N   . LYS   A 1 239 ? -15.20009 17.15719  -39.56773 1.000 9.31733  ? 239 LYS   A N   1 
ATOM   1200 C  CA  . LYS   A 1 239 ? -15.75085 18.46812  -39.91426 1.000 17.22484 ? 239 LYS   A CA  1 
ATOM   1201 C  C   . LYS   A 1 239 ? -15.45116 19.51003  -38.83818 1.000 15.87043 ? 239 LYS   A C   1 
ATOM   1202 O  O   . LYS   A 1 239 ? -15.15890 20.66592  -39.14821 1.000 18.05555 ? 239 LYS   A O   1 
ATOM   1203 C  CB  . LYS   A 1 239 ? -17.26374 18.34241  -40.13716 1.000 16.58777 ? 239 LYS   A CB  1 
ATOM   1204 C  CG  . LYS   A 1 239 ? -18.02316 19.64821  -40.37505 1.000 30.35232 ? 239 LYS   A CG  1 
ATOM   1205 C  CD  . LYS   A 1 239 ? -17.74848 20.21982  -41.77502 1.000 32.33218 ? 239 LYS   A CD  1 
ATOM   1206 C  CE  . LYS   A 1 239 ? -18.62890 21.42732  -42.10232 1.000 38.98863 ? 239 LYS   A CE  1 
ATOM   1207 N  NZ  . LYS   A 1 239 ? -20.08709 21.08030  -42.17397 1.000 45.58662 ? 239 LYS   A NZ  1 
ATOM   1208 N  N   . LEU   A 1 240 ? -15.50393 19.11806  -37.56873 1.000 16.28736 ? 240 LEU   A N   1 
ATOM   1209 C  CA  . LEU   A 1 240 ? -15.25301 20.07114  -36.49878 1.000 16.36796 ? 240 LEU   A CA  1 
ATOM   1210 C  C   . LEU   A 1 240 ? -13.81026 20.55456  -36.48198 1.000 19.52970 ? 240 LEU   A C   1 
ATOM   1211 O  O   . LEU   A 1 240 ? -13.53754 21.60584  -35.88890 1.000 18.35573 ? 240 LEU   A O   1 
ATOM   1212 C  CB  . LEU   A 1 240 ? -15.62891 19.45251  -35.15273 1.000 12.16661 ? 240 LEU   A CB  1 
ATOM   1213 C  CG  . LEU   A 1 240 ? -17.12407 19.13829  -35.03145 1.000 10.97423 ? 240 LEU   A CG  1 
ATOM   1214 C  CD1 . LEU   A 1 240 ? -17.37473 18.26759  -33.81229 1.000 7.56304  ? 240 LEU   A CD1 1 
ATOM   1215 C  CD2 . LEU   A 1 240 ? -17.96915 20.42397  -34.98464 1.000 9.29643  ? 240 LEU   A CD2 1 
ATOM   1216 N  N   . LEU   A 1 241 ? -12.89139 19.80467  -37.10630 1.000 15.78816 ? 241 LEU   A N   1 
ATOM   1217 C  CA  . LEU   A 1 241 ? -11.51267 20.26392  -37.27471 1.000 17.93326 ? 241 LEU   A CA  1 
ATOM   1218 C  C   . LEU   A 1 241 ? -11.44769 21.57374  -38.03690 1.000 17.93844 ? 241 LEU   A C   1 
ATOM   1219 O  O   . LEU   A 1 241 ? -10.46993 22.32135  -37.89702 1.000 17.87759 ? 241 LEU   A O   1 
ATOM   1220 C  CB  . LEU   A 1 241 ? -10.67667 19.22647  -38.02558 1.000 12.97448 ? 241 LEU   A CB  1 
ATOM   1221 C  CG  . LEU   A 1 241 ? -10.41021 17.90751  -37.32566 1.000 11.32574 ? 241 LEU   A CG  1 
ATOM   1222 C  CD1 . LEU   A 1 241 ? -9.85167  16.86982  -38.30380 1.000 13.33044 ? 241 LEU   A CD1 1 
ATOM   1223 C  CD2 . LEU   A 1 241 ? -9.43997  18.17983  -36.19347 1.000 12.34489 ? 241 LEU   A CD2 1 
ATOM   1224 N  N   . GLN   A 1 242 ? -12.46424 21.86089  -38.84975 1.000 15.62825 ? 242 GLN   A N   1 
ATOM   1225 C  CA  . GLN   A 1 242 ? -12.48182 23.05090  -39.68818 1.000 22.32470 ? 242 GLN   A CA  1 
ATOM   1226 C  C   . GLN   A 1 242 ? -13.04595 24.27737  -38.98871 1.000 22.17084 ? 242 GLN   A C   1 
ATOM   1227 O  O   . GLN   A 1 242 ? -13.02663 25.36163  -39.57611 1.000 28.50429 ? 242 GLN   A O   1 
ATOM   1228 C  CB  . GLN   A 1 242 ? -13.28184 22.77811  -40.95390 1.000 21.41039 ? 242 GLN   A CB  1 
ATOM   1229 C  CG  . GLN   A 1 242 ? -12.68554 21.66821  -41.74038 1.000 23.60673 ? 242 GLN   A CG  1 
ATOM   1230 C  CD  . GLN   A 1 242 ? -13.62391 21.14538  -42.80201 1.000 37.85681 ? 242 GLN   A CD  1 
ATOM   1231 O  OE1 . GLN   A 1 242 ? -14.69146 21.71893  -43.04756 1.000 37.64099 ? 242 GLN   A OE1 1 
ATOM   1232 N  NE2 . GLN   A 1 242 ? -13.22703 20.04883  -43.44964 1.000 27.70344 ? 242 GLN   A NE2 1 
ATOM   1233 N  N   . GLU   A 1 243 ? -13.54972 24.13539  -37.76625 1.000 26.19664 ? 243 GLU   A N   1 
ATOM   1234 C  CA  . GLU   A 1 243 ? -14.03411 25.27431  -37.00175 1.000 22.86647 ? 243 GLU   A CA  1 
ATOM   1235 C  C   . GLU   A 1 243 ? -12.85180 26.11393  -36.53020 1.000 21.27740 ? 243 GLU   A C   1 
ATOM   1236 O  O   . GLU   A 1 243 ? -11.68946 25.71432  -36.65746 1.000 17.07879 ? 243 GLU   A O   1 
ATOM   1237 C  CB  . GLU   A 1 243 ? -14.86671 24.79723  -35.81146 1.000 18.43363 ? 243 GLU   A CB  1 
ATOM   1238 C  CG  . GLU   A 1 243 ? -16.08898 24.00520  -36.22863 1.000 23.37613 ? 243 GLU   A CG  1 
ATOM   1239 C  CD  . GLU   A 1 243 ? -17.20300 24.90127  -36.67445 1.000 25.74205 ? 243 GLU   A CD  1 
ATOM   1240 O  OE1 . GLU   A 1 243 ? -17.67626 25.69432  -35.83702 1.000 42.39820 ? 243 GLU   A OE1 1 
ATOM   1241 O  OE2 . GLU   A 1 243 ? -17.58752 24.83638  -37.85740 1.000 31.04918 ? 243 GLU   A OE2 1 
ATOM   1242 N  N   . GLU   A 1 244 ? -13.15670 27.27635  -35.94437 1.000 18.57995 ? 244 GLU   A N   1 
ATOM   1243 C  CA  . GLU   A 1 244 ? -12.12838 28.28898  -35.71189 1.000 16.57308 ? 244 GLU   A CA  1 
ATOM   1244 C  C   . GLU   A 1 244 ? -11.11681 27.79643  -34.68453 1.000 15.79408 ? 244 GLU   A C   1 
ATOM   1245 O  O   . GLU   A 1 244 ? -11.48439 27.42217  -33.56536 1.000 16.49915 ? 244 GLU   A O   1 
ATOM   1246 C  CB  . GLU   A 1 244 ? -12.76465 29.60242  -35.26793 1.000 13.75232 ? 244 GLU   A CB  1 
ATOM   1247 C  CG  . GLU   A 1 244 ? -11.75467 30.67597  -34.88348 1.000 28.99919 ? 244 GLU   A CG  1 
ATOM   1248 C  CD  . GLU   A 1 244 ? -12.40135 31.89852  -34.21721 1.000 30.41337 ? 244 GLU   A CD  1 
ATOM   1249 O  OE1 . GLU   A 1 244 ? -12.55668 31.88779  -32.97973 1.000 29.99780 ? 244 GLU   A OE1 1 
ATOM   1250 O  OE2 . GLU   A 1 244 ? -12.75312 32.86664  -34.92469 1.000 29.95236 ? 244 GLU   A OE2 1 
ATOM   1251 N  N   . ASN   A 1 245 ? -9.84340  27.77692  -35.08368 1.000 15.37129 ? 245 ASN   A N   1 
ATOM   1252 C  CA  . ASN   A 1 245 ? -8.74881  27.28874  -34.24934 1.000 13.03679 ? 245 ASN   A CA  1 
ATOM   1253 C  C   . ASN   A 1 245 ? -9.02712  25.88594  -33.72078 1.000 17.80603 ? 245 ASN   A C   1 
ATOM   1254 O  O   . ASN   A 1 245 ? -8.70592  25.55578  -32.57646 1.000 19.21001 ? 245 ASN   A O   1 
ATOM   1255 C  CB  . ASN   A 1 245 ? -8.46489  28.24231  -33.08937 1.000 13.86031 ? 245 ASN   A CB  1 
ATOM   1256 C  CG  . ASN   A 1 245 ? -7.10665  27.99728  -32.46977 1.000 15.04388 ? 245 ASN   A CG  1 
ATOM   1257 O  OD1 . ASN   A 1 245 ? -6.25497  27.32137  -33.05731 1.000 24.59027 ? 245 ASN   A OD1 1 
ATOM   1258 N  ND2 . ASN   A 1 245 ? -6.89466  28.53346  -31.28216 1.000 15.80382 ? 245 ASN   A ND2 1 
ATOM   1259 N  N   . CYS   A 1 246 ? -9.62233  25.04287  -34.55854 1.000 15.45450 ? 246 CYS   A N   1 
ATOM   1260 C  CA  . CYS   A 1 246 ? -9.91064  23.67765  -34.15256 1.000 17.43968 ? 246 CYS   A CA  1 
ATOM   1261 C  C   . CYS   A 1 246 ? -9.05494  22.63686  -34.85646 1.000 18.86505 ? 246 CYS   A C   1 
ATOM   1262 O  O   . CYS   A 1 246 ? -9.16866  21.45508  -34.52903 1.000 16.45988 ? 246 CYS   A O   1 
ATOM   1263 C  CB  . CYS   A 1 246 ? -11.38619 23.35571  -34.38054 1.000 16.14054 ? 246 CYS   A CB  1 
ATOM   1264 S  SG  . CYS   A 1 246 ? -12.46380 23.96136  -33.08589 1.000 17.56120 ? 246 CYS   A SG  1 
ATOM   1265 N  N   . ASP   A 1 247 ? -8.21812  23.02190  -35.82200 1.000 18.33066 ? 247 ASP   A N   1 
ATOM   1266 C  CA  . ASP   A 1 247 ? -7.50524  22.01409  -36.59401 1.000 17.34768 ? 247 ASP   A CA  1 
ATOM   1267 C  C   . ASP   A 1 247 ? -6.23358  21.66674  -35.84127 1.000 18.27861 ? 247 ASP   A C   1 
ATOM   1268 O  O   . ASP   A 1 247 ? -5.17277  22.27252  -36.02938 1.000 17.44113 ? 247 ASP   A O   1 
ATOM   1269 C  CB  . ASP   A 1 247 ? -7.21928  22.45949  -38.02059 1.000 15.89872 ? 247 ASP   A CB  1 
ATOM   1270 C  CG  . ASP   A 1 247 ? -6.57068  21.33293  -38.85647 1.000 20.50252 ? 247 ASP   A CG  1 
ATOM   1271 O  OD1 . ASP   A 1 247 ? -6.59237  20.15210  -38.43007 1.000 15.05393 ? 247 ASP   A OD1 1 
ATOM   1272 O  OD2 . ASP   A 1 247 ? -6.03117  21.62642  -39.94223 1.000 30.15446 ? 247 ASP   A OD2 1 
ATOM   1273 N  N   . ILE   A 1 248 ? -6.35778  20.64197  -34.99746 1.000 11.39131 ? 248 ILE   A N   1 
ATOM   1274 C  CA  . ILE   A 1 248 ? -5.23957  20.08053  -34.25661 1.000 13.15111 ? 248 ILE   A CA  1 
ATOM   1275 C  C   . ILE   A 1 248 ? -4.26223  19.30389  -35.12780 1.000 15.80629 ? 248 ILE   A C   1 
ATOM   1276 O  O   . ILE   A 1 248 ? -3.20656  18.91456  -34.63111 1.000 10.97984 ? 248 ILE   A O   1 
ATOM   1277 C  CB  . ILE   A 1 248 ? -5.77267  19.16254  -33.13970 1.000 12.99845 ? 248 ILE   A CB  1 
ATOM   1278 C  CG1 . ILE   A 1 248 ? -6.66515  18.05867  -33.73227 1.000 11.79952 ? 248 ILE   A CG1 1 
ATOM   1279 C  CG2 . ILE   A 1 248 ? -6.54107  19.97877  -32.14241 1.000 15.30823 ? 248 ILE   A CG2 1 
ATOM   1280 C  CD1 . ILE   A 1 248 ? -6.92414  16.90010  -32.78571 1.000 10.65051 ? 248 ILE   A CD1 1 
ATOM   1281 N  N   . PHE   A 1 249 ? -4.58981  19.05367  -36.40015 1.000 13.94859 ? 249 PHE   A N   1 
ATOM   1282 C  CA  . PHE   A 1 249 ? -3.66738  18.43583  -37.34555 1.000 15.26941 ? 249 PHE   A CA  1 
ATOM   1283 C  C   . PHE   A 1 249 ? -3.07771  19.45313  -38.34093 1.000 21.06969 ? 249 PHE   A C   1 
ATOM   1284 O  O   . PHE   A 1 249 ? -2.63263  19.06292  -39.42808 1.000 21.70065 ? 249 PHE   A O   1 
ATOM   1285 C  CB  . PHE   A 1 249 ? -4.37961  17.30588  -38.10992 1.000 17.90543 ? 249 PHE   A CB  1 
ATOM   1286 C  CG  . PHE   A 1 249 ? -5.09129  16.28928  -37.21617 1.000 12.88013 ? 249 PHE   A CG  1 
ATOM   1287 C  CD1 . PHE   A 1 249 ? -4.42393  15.65351  -36.18312 1.000 14.84070 ? 249 PHE   A CD1 1 
ATOM   1288 C  CD2 . PHE   A 1 249 ? -6.43544  16.00883  -37.40009 1.000 14.40117 ? 249 PHE   A CD2 1 
ATOM   1289 C  CE1 . PHE   A 1 249 ? -5.08942  14.73822  -35.35867 1.000 19.55832 ? 249 PHE   A CE1 1 
ATOM   1290 C  CE2 . PHE   A 1 249 ? -7.11257  15.07732  -36.58910 1.000 12.71141 ? 249 PHE   A CE2 1 
ATOM   1291 C  CZ  . PHE   A 1 249 ? -6.43757  14.44732  -35.57318 1.000 15.32821 ? 249 PHE   A CZ  1 
ATOM   1292 N  N   . GLN   A 1 250 ? -3.08694  20.74977  -38.00814 1.000 16.28696 ? 250 GLN   A N   1 
ATOM   1293 C  CA  . GLN   A 1 250 ? -2.65678  21.77684  -38.96717 1.000 20.17232 ? 250 GLN   A CA  1 
ATOM   1294 C  C   . GLN   A 1 250 ? -1.17836  21.68218  -39.33462 1.000 18.66273 ? 250 GLN   A C   1 
ATOM   1295 O  O   . GLN   A 1 250 ? -0.79363  22.13161  -40.42141 1.000 17.88498 ? 250 GLN   A O   1 
ATOM   1296 C  CB  . GLN   A 1 250 ? -2.93390  23.17482  -38.42213 1.000 16.41982 ? 250 GLN   A CB  1 
ATOM   1297 C  CG  . GLN   A 1 250 ? -2.32313  23.40647  -37.05583 1.000 21.17062 ? 250 GLN   A CG  1 
ATOM   1298 C  CD  . GLN   A 1 250 ? -2.76823  24.72305  -36.44577 1.000 29.96450 ? 250 GLN   A CD  1 
ATOM   1299 O  OE1 . GLN   A 1 250 ? -1.93384  25.59380  -36.16376 1.000 28.69622 ? 250 GLN   A OE1 1 
ATOM   1300 N  NE2 . GLN   A 1 250 ? -4.08883  24.88645  -36.24667 1.000 20.50325 ? 250 GLN   A NE2 1 
ATOM   1301 N  N   . ASN   A 1 251 ? -0.35220  21.09251  -38.47664 1.000 17.11205 ? 251 ASN   A N   1 
ATOM   1302 C  CA  . ASN   A 1 251 ? 1.07492   20.99425  -38.71882 1.000 17.21097 ? 251 ASN   A CA  1 
ATOM   1303 C  C   . ASN   A 1 251 ? 1.53388   19.60881  -39.11873 1.000 21.88908 ? 251 ASN   A C   1 
ATOM   1304 O  O   . ASN   A 1 251 ? 2.73805   19.39850  -39.24454 1.000 21.78175 ? 251 ASN   A O   1 
ATOM   1305 C  CB  . ASN   A 1 251 ? 1.84914   21.44183  -37.48170 1.000 16.66383 ? 251 ASN   A CB  1 
ATOM   1306 C  CG  . ASN   A 1 251 ? 1.70138   22.91395  -37.23474 1.000 17.98448 ? 251 ASN   A CG  1 
ATOM   1307 O  OD1 . ASN   A 1 251 ? 1.44311   23.67678  -38.15915 1.000 21.45371 ? 251 ASN   A OD1 1 
ATOM   1308 N  ND2 . ASN   A 1 251 ? 1.83031   23.32088  -35.98987 1.000 20.55639 ? 251 ASN   A ND2 1 
ATOM   1309 N  N   . LEU   A 1 252 ? 0.63050   18.64978  -39.29574 1.000 19.30622 ? 252 LEU   A N   1 
ATOM   1310 C  CA  . LEU   A 1 252 ? 1.06894   17.39729  -39.88257 1.000 17.69441 ? 252 LEU   A CA  1 
ATOM   1311 C  C   . LEU   A 1 252 ? 1.40036   17.62958  -41.34568 1.000 18.11590 ? 252 LEU   A C   1 
ATOM   1312 O  O   . LEU   A 1 252 ? 0.86494   18.53712  -41.98255 1.000 21.12049 ? 252 LEU   A O   1 
ATOM   1313 C  CB  . LEU   A 1 252 ? -0.00490  16.31172  -39.75209 1.000 19.59601 ? 252 LEU   A CB  1 
ATOM   1314 C  CG  . LEU   A 1 252 ? -0.04546  15.46770  -38.48245 1.000 20.11400 ? 252 LEU   A CG  1 
ATOM   1315 C  CD1 . LEU   A 1 252 ? -0.16904  16.35393  -37.23394 1.000 18.45034 ? 252 LEU   A CD1 1 
ATOM   1316 C  CD2 . LEU   A 1 252 ? -1.18968  14.42633  -38.54275 1.000 19.42159 ? 252 LEU   A CD2 1 
ATOM   1317 N  N   . THR   A 1 253 ? 2.29380   16.80345  -41.88221 1.000 25.85910 ? 253 THR   A N   1 
ATOM   1318 C  CA  . THR   A 1 253 ? 2.51644   16.84468  -43.32039 1.000 21.65485 ? 253 THR   A CA  1 
ATOM   1319 C  C   . THR   A 1 253 ? 1.26695   16.36533  -44.05588 1.000 25.65366 ? 253 THR   A C   1 
ATOM   1320 O  O   . THR   A 1 253 ? 0.36603   15.73997  -43.48158 1.000 17.99915 ? 253 THR   A O   1 
ATOM   1321 C  CB  . THR   A 1 253 ? 3.71550   15.98223  -43.73098 1.000 20.89538 ? 253 THR   A CB  1 
ATOM   1322 O  OG1 . THR   A 1 253 ? 3.49869   14.62221  -43.34190 1.000 22.02395 ? 253 THR   A OG1 1 
ATOM   1323 C  CG2 . THR   A 1 253 ? 5.01036   16.47867  -43.07915 1.000 24.80528 ? 253 THR   A CG2 1 
ATOM   1324 N  N   . LYS   A 1 254 ? 1.22713   16.66671  -45.35843 1.000 26.91120 ? 254 LYS   A N   1 
ATOM   1325 C  CA  . LYS   A 1 254 ? 0.12163   16.21204  -46.18690 1.000 26.37807 ? 254 LYS   A CA  1 
ATOM   1326 C  C   . LYS   A 1 254 ? 0.03826   14.68975  -46.19962 1.000 26.62259 ? 254 LYS   A C   1 
ATOM   1327 O  O   . LYS   A 1 254 ? -1.05317  14.11500  -46.07708 1.000 31.32706 ? 254 LYS   A O   1 
ATOM   1328 C  CB  . LYS   A 1 254 ? 0.25625   16.76912  -47.60363 1.000 35.52303 ? 254 LYS   A CB  1 
ATOM   1329 C  CG  . LYS   A 1 254 ? -0.89045  16.34215  -48.49162 1.000 37.57072 ? 254 LYS   A CG  1 
ATOM   1330 C  CD  . LYS   A 1 254 ? -2.18893  16.95499  -47.94204 1.000 48.91533 ? 254 LYS   A CD  1 
ATOM   1331 C  CE  . LYS   A 1 254 ? -3.22635  15.86104  -47.54776 1.000 53.53332 ? 254 LYS   A CE  1 
ATOM   1332 N  NZ  . LYS   A 1 254 ? -4.51717  16.31735  -46.92458 1.000 50.01270 ? 254 LYS   A NZ  1 
ATOM   1333 N  N   . LYS   A 1 255 ? 1.17913   14.01539  -46.29935 1.000 21.08254 ? 255 LYS   A N   1 
ATOM   1334 C  CA  . LYS   A 1 255 ? 1.14539   12.56007  -46.25580 1.000 24.76873 ? 255 LYS   A CA  1 
ATOM   1335 C  C   . LYS   A 1 255 ? 0.71389   12.04661  -44.87733 1.000 23.82796 ? 255 LYS   A C   1 
ATOM   1336 O  O   . LYS   A 1 255 ? 0.02373   11.02033  -44.78921 1.000 19.78635 ? 255 LYS   A O   1 
ATOM   1337 C  CB  . LYS   A 1 255 ? 2.50976   12.00504  -46.65902 1.000 23.57418 ? 255 LYS   A CB  1 
ATOM   1338 C  CG  . LYS   A 1 255 ? 2.78940   10.57383  -46.17935 1.000 41.66498 ? 255 LYS   A CG  1 
ATOM   1339 C  CD  . LYS   A 1 255 ? 4.02472   9.94375   -46.86317 1.000 47.37392 ? 255 LYS   A CD  1 
ATOM   1340 C  CE  . LYS   A 1 255 ? 4.93872   9.22122   -45.86053 1.000 52.13019 ? 255 LYS   A CE  1 
ATOM   1341 N  NZ  . LYS   A 1 255 ? 5.47928   10.14495  -44.81172 1.000 46.19646 ? 255 LYS   A NZ  1 
ATOM   1342 N  N   . GLN   A 1 256 ? 1.09872   12.75355  -43.80284 1.000 21.28581 ? 256 GLN   A N   1 
ATOM   1343 C  CA  . GLN   A 1 256 ? 0.69708   12.38056  -42.43948 1.000 19.80344 ? 256 GLN   A CA  1 
ATOM   1344 C  C   . GLN   A 1 256 ? -0.81322  12.46909  -42.26648 1.000 14.51527 ? 256 GLN   A C   1 
ATOM   1345 O  O   . GLN   A 1 256 ? -1.45430  11.53357  -41.77463 1.000 14.42855 ? 256 GLN   A O   1 
ATOM   1346 C  CB  . GLN   A 1 256 ? 1.37333   13.29578  -41.41360 1.000 16.87626 ? 256 GLN   A CB  1 
ATOM   1347 C  CG  . GLN   A 1 256 ? 2.76707   12.88678  -40.93833 1.000 18.37038 ? 256 GLN   A CG  1 
ATOM   1348 C  CD  . GLN   A 1 256 ? 3.37638   13.92668  -39.99937 1.000 15.77134 ? 256 GLN   A CD  1 
ATOM   1349 O  OE1 . GLN   A 1 256 ? 3.13699   15.13192  -40.14460 1.000 23.45258 ? 256 GLN   A OE1 1 
ATOM   1350 N  NE2 . GLN   A 1 256 ? 4.16058   13.46792  -39.03572 1.000 17.27865 ? 256 GLN   A NE2 1 
ATOM   1351 N  N   . ARG   A 1 257 ? -1.38417  13.62096  -42.62688 1.000 20.14711 ? 257 ARG   A N   1 
ATOM   1352 C  CA  . ARG   A 1 257 ? -2.82547  13.80241  -42.61662 1.000 17.44045 ? 257 ARG   A CA  1 
ATOM   1353 C  C   . ARG   A 1 257 ? -3.52582  12.72245  -43.43056 1.000 18.15196 ? 257 ARG   A C   1 
ATOM   1354 O  O   . ARG   A 1 257 ? -4.53680  12.16734  -42.98839 1.000 14.14820 ? 257 ARG   A O   1 
ATOM   1355 C  CB  . ARG   A 1 257 ? -3.16931  15.19059  -43.14706 1.000 19.32533 ? 257 ARG   A CB  1 
ATOM   1356 C  CG  . ARG   A 1 257 ? -3.27819  16.25998  -42.05077 1.000 32.37380 ? 257 ARG   A CG  1 
ATOM   1357 C  CD  . ARG   A 1 257 ? -2.54317  17.59321  -42.36982 1.000 23.59462 ? 257 ARG   A CD  1 
ATOM   1358 N  NE  . ARG   A 1 257 ? -3.28291  18.46903  -43.27371 1.000 32.76937 ? 257 ARG   A NE  1 
ATOM   1359 C  CZ  . ARG   A 1 257 ? -3.07308  19.78316  -43.41035 1.000 37.40243 ? 257 ARG   A CZ  1 
ATOM   1360 N  NH1 . ARG   A 1 257 ? -2.15447  20.41765  -42.68065 1.000 20.74776 ? 257 ARG   A NH1 1 
ATOM   1361 N  NH2 . ARG   A 1 257 ? -3.79798  20.47690  -44.27979 1.000 41.61792 ? 257 ARG   A NH2 1 
ATOM   1362 N  N   . GLN   A 1 258 ? -3.01202  12.41448  -44.62723 1.000 17.56370 ? 258 GLN   A N   1 
ATOM   1363 C  CA  . GLN   A 1 258 ? -3.66085  11.40655  -45.46506 1.000 17.70472 ? 258 GLN   A CA  1 
ATOM   1364 C  C   . GLN   A 1 258 ? -3.70723  10.06244  -44.75232 1.000 16.01781 ? 258 GLN   A C   1 
ATOM   1365 O  O   . GLN   A 1 258 ? -4.77327  9.43733   -44.63035 1.000 12.10981 ? 258 GLN   A O   1 
ATOM   1366 C  CB  . GLN   A 1 258 ? -2.92620  11.27466  -46.80590 1.000 18.53630 ? 258 GLN   A CB  1 
ATOM   1367 C  CG  . GLN   A 1 258 ? -3.81987  10.90451  -47.97498 1.000 25.61957 ? 258 GLN   A CG  1 
ATOM   1368 C  CD  . GLN   A 1 258 ? -3.05501  10.64099  -49.27786 1.000 34.76154 ? 258 GLN   A CD  1 
ATOM   1369 O  OE1 . GLN   A 1 258 ? -1.87654  10.97616  -49.41152 1.000 36.70776 ? 258 GLN   A OE1 1 
ATOM   1370 N  NE2 . GLN   A 1 258 ? -3.73898  10.04358  -50.24515 1.000 26.50960 ? 258 GLN   A NE2 1 
ATOM   1371 N  N   . SER   A 1 259 ? -2.54909  9.60685   -44.27158 1.000 12.30457 ? 259 SER   A N   1 
ATOM   1372 C  CA  . SER   A 1 259 ? -2.47021  8.31977   -43.59145 1.000 12.99035 ? 259 SER   A CA  1 
ATOM   1373 C  C   . SER   A 1 259 ? -3.34462  8.31001   -42.34311 1.000 14.07188 ? 259 SER   A C   1 
ATOM   1374 O  O   . SER   A 1 259 ? -4.01999  7.31160   -42.05037 1.000 12.64565 ? 259 SER   A O   1 
ATOM   1375 C  CB  . SER   A 1 259 ? -1.00326  8.01978   -43.25919 1.000 15.73903 ? 259 SER   A CB  1 
ATOM   1376 O  OG  . SER   A 1 259 ? -0.83260  7.13367   -42.16628 1.000 16.85613 ? 259 SER   A OG  1 
ATOM   1377 N  N   . LEU   A 1 260 ? -3.34673  9.42201   -41.60148 1.000 13.52986 ? 260 LEU   A N   1 
ATOM   1378 C  CA  . LEU   A 1 260 ? -4.13356  9.52012   -40.37602 1.000 13.78050 ? 260 LEU   A CA  1 
ATOM   1379 C  C   . LEU   A 1 260 ? -5.61117  9.37365   -40.67756 1.000 14.38700 ? 260 LEU   A C   1 
ATOM   1380 O  O   . LEU   A 1 260 ? -6.31159  8.56071   -40.05920 1.000 15.10891 ? 260 LEU   A O   1 
ATOM   1381 C  CB  . LEU   A 1 260 ? -3.86700  10.86106  -39.69167 1.000 15.17140 ? 260 LEU   A CB  1 
ATOM   1382 C  CG  . LEU   A 1 260 ? -4.76147  11.19753  -38.49232 1.000 16.84892 ? 260 LEU   A CG  1 
ATOM   1383 C  CD1 . LEU   A 1 260 ? -4.65338  10.09187  -37.56272 1.000 16.17026 ? 260 LEU   A CD1 1 
ATOM   1384 C  CD2 . LEU   A 1 260 ? -4.30063  12.43952  -37.77089 1.000 21.30856 ? 260 LEU   A CD2 1 
ATOM   1385 N  N   . ARG   A 1 261 ? -6.09205  10.16006  -41.63578 1.000 11.42783 ? 261 ARG   A N   1 
ATOM   1386 C  CA  . ARG   A 1 261 ? -7.49894  10.15589  -41.99567 1.000 10.04686 ? 261 ARG   A CA  1 
ATOM   1387 C  C   . ARG   A 1 261 ? -7.97431  8.75295   -42.34660 1.000 12.93305 ? 261 ARG   A C   1 
ATOM   1388 O  O   . ARG   A 1 261 ? -9.02320  8.30870   -41.86164 1.000 10.17524 ? 261 ARG   A O   1 
ATOM   1389 C  CB  . ARG   A 1 261 ? -7.74277  11.12510  -43.16267 1.000 11.52628 ? 261 ARG   A CB  1 
ATOM   1390 C  CG  . ARG   A 1 261 ? -9.23788  11.22249  -43.60625 1.000 13.78917 ? 261 ARG   A CG  1 
ATOM   1391 C  CD  . ARG   A 1 261 ? -9.51226  12.34704  -44.62606 1.000 11.50664 ? 261 ARG   A CD  1 
ATOM   1392 N  NE  . ARG   A 1 261 ? -10.78331 12.08601  -45.32132 1.000 13.32533 ? 261 ARG   A NE  1 
ATOM   1393 C  CZ  . ARG   A 1 261 ? -11.99062 12.38091  -44.83752 1.000 15.53629 ? 261 ARG   A CZ  1 
ATOM   1394 N  NH1 . ARG   A 1 261 ? -12.11049 12.96924  -43.65286 1.000 15.50444 ? 261 ARG   A NH1 1 
ATOM   1395 N  NH2 . ARG   A 1 261 ? -13.08435 12.07830  -45.52897 1.000 12.75258 ? 261 ARG   A NH2 1 
ATOM   1396 N  N   . LYS   A 1 262 ? -7.21833  8.04264   -43.20418 1.000 13.29595 ? 262 LYS   A N   1 
ATOM   1397 C  CA  . LYS   A 1 262 ? -7.60588  6.68258   -43.57967 1.000 13.07789 ? 262 LYS   A CA  1 
ATOM   1398 C  C   . LYS   A 1 262 ? -7.62129  5.75281   -42.37014 1.000 9.79088  ? 262 LYS   A C   1 
ATOM   1399 O  O   . LYS   A 1 262 ? -8.54890  4.95722   -42.20278 1.000 11.65317 ? 262 LYS   A O   1 
ATOM   1400 C  CB  . LYS   A 1 262 ? -6.67049  6.10295   -44.65287 1.000 12.11916 ? 262 LYS   A CB  1 
ATOM   1401 C  CG  . LYS   A 1 262 ? -6.98011  4.59560   -44.92815 1.000 11.06482 ? 262 LYS   A CG  1 
ATOM   1402 C  CD  . LYS   A 1 262 ? -6.29017  4.04811   -46.16080 1.000 19.32623 ? 262 LYS   A CD  1 
ATOM   1403 C  CE  . LYS   A 1 262 ? -6.88162  2.69891   -46.59378 1.000 19.69293 ? 262 LYS   A CE  1 
ATOM   1404 N  NZ  . LYS   A 1 262 ? -8.22853  2.90987   -47.19354 1.000 31.87882 ? 262 LYS   A NZ  1 
ATOM   1405 N  N   . MET   A 1 263 ? -6.59981  5.83972   -41.51628 1.000 10.97018 ? 263 MET   A N   1 
ATOM   1406 C  CA  . MET   A 1 263 ? -6.55653  4.99328   -40.33301 1.000 10.08577 ? 263 MET   A CA  1 
ATOM   1407 C  C   . MET   A 1 263 ? -7.75502  5.25444   -39.42024 1.000 11.83170 ? 263 MET   A C   1 
ATOM   1408 O  O   . MET   A 1 263 ? -8.36176  4.31479   -38.90464 1.000 8.55859  ? 263 MET   A O   1 
ATOM   1409 C  CB  . MET   A 1 263 ? -5.23733  5.21188   -39.58792 1.000 7.98593  ? 263 MET   A CB  1 
ATOM   1410 C  CG  . MET   A 1 263 ? -4.02131  4.63157   -40.29184 1.000 14.82070 ? 263 MET   A CG  1 
ATOM   1411 S  SD  . MET   A 1 263 ? -2.59144  4.44906   -39.20898 1.000 17.32046 ? 263 MET   A SD  1 
ATOM   1412 C  CE  . MET   A 1 263 ? -2.18599  6.17969   -38.92585 1.000 14.26484 ? 263 MET   A CE  1 
ATOM   1413 N  N   . VAL   A 1 264 ? -8.10672  6.53069   -39.22085 1.000 13.93864 ? 264 VAL   A N   1 
ATOM   1414 C  CA  . VAL   A 1 264 ? -9.23401  6.90124   -38.36700 1.000 9.21365  ? 264 VAL   A CA  1 
ATOM   1415 C  C   . VAL   A 1 264 ? -10.53855 6.33085   -38.91937 1.000 10.97036 ? 264 VAL   A C   1 
ATOM   1416 O  O   . VAL   A 1 264 ? -11.33850 5.72342   -38.18858 1.000 8.24055  ? 264 VAL   A O   1 
ATOM   1417 C  CB  . VAL   A 1 264 ? -9.30910  8.43352   -38.24251 1.000 11.49349 ? 264 VAL   A CB  1 
ATOM   1418 C  CG1 . VAL   A 1 264 ? -10.62883 8.84322   -37.59020 1.000 11.41360 ? 264 VAL   A CG1 1 
ATOM   1419 C  CG2 . VAL   A 1 264 ? -8.10494  8.96299   -37.46002 1.000 11.78793 ? 264 VAL   A CG2 1 
ATOM   1420 N  N   . ILE   A 1 265 ? -10.78068 6.54851   -40.21980 1.000 9.27395  ? 265 ILE   A N   1 
ATOM   1421 C  CA  . ILE   A 1 265 ? -11.96240 5.99199   -40.86974 1.000 11.01893 ? 265 ILE   A CA  1 
ATOM   1422 C  C   . ILE   A 1 265 ? -11.98985 4.47862   -40.69571 1.000 10.93127 ? 265 ILE   A C   1 
ATOM   1423 O  O   . ILE   A 1 265 ? -13.00959 3.89859   -40.29834 1.000 9.34753  ? 265 ILE   A O   1 
ATOM   1424 C  CB  . ILE   A 1 265 ? -11.99485 6.38593   -42.36123 1.000 10.04156 ? 265 ILE   A CB  1 
ATOM   1425 C  CG1 . ILE   A 1 265 ? -12.25048 7.88464   -42.53079 1.000 9.02701  ? 265 ILE   A CG1 1 
ATOM   1426 C  CG2 . ILE   A 1 265 ? -13.06164 5.57506   -43.10231 1.000 10.19108 ? 265 ILE   A CG2 1 
ATOM   1427 C  CD1 . ILE   A 1 265 ? -11.77571 8.44458   -43.85434 1.000 8.34932  ? 265 ILE   A CD1 1 
ATOM   1428 N  N   . ASP   A 1 266 ? -10.85110 3.82013   -40.95781 1.000 9.60079  ? 266 ASP   A N   1 
ATOM   1429 C  CA  . ASP   A 1 266 ? -10.82534 2.36622   -40.88608 1.000 10.99291 ? 266 ASP   A CA  1 
ATOM   1430 C  C   . ASP   A 1 266 ? -11.14822 1.89412   -39.48104 1.000 11.13949 ? 266 ASP   A C   1 
ATOM   1431 O  O   . ASP   A 1 266 ? -11.82481 0.88246   -39.30336 1.000 9.63113  ? 266 ASP   A O   1 
ATOM   1432 C  CB  . ASP   A 1 266 ? -9.47061  1.82712   -41.34706 1.000 11.42388 ? 266 ASP   A CB  1 
ATOM   1433 C  CG  . ASP   A 1 266 ? -9.31196  1.85078   -42.89261 1.000 10.64185 ? 266 ASP   A CG  1 
ATOM   1434 O  OD1 . ASP   A 1 266 ? -10.30319 2.05424   -43.61521 1.000 8.06262  ? 266 ASP   A OD1 1 
ATOM   1435 O  OD2 . ASP   A 1 266 ? -8.18609  1.65096   -43.38377 1.000 11.27387 ? 266 ASP   A OD2 1 
ATOM   1436 N  N   . ILE   A 1 267 ? -10.68744 2.62810   -38.47119 1.000 9.39040  ? 267 ILE   A N   1 
ATOM   1437 C  CA  . ILE   A 1 267 ? -10.95240 2.24527   -37.09065 1.000 9.83962  ? 267 ILE   A CA  1 
ATOM   1438 C  C   . ILE   A 1 267 ? -12.41561 2.51448   -36.71876 1.000 11.73234 ? 267 ILE   A C   1 
ATOM   1439 O  O   . ILE   A 1 267 ? -13.10460 1.63020   -36.20818 1.000 11.53770 ? 267 ILE   A O   1 
ATOM   1440 C  CB  . ILE   A 1 267 ? -9.98285  2.97825   -36.14530 1.000 8.11124  ? 267 ILE   A CB  1 
ATOM   1441 C  CG1 . ILE   A 1 267 ? -8.54323  2.46670   -36.36078 1.000 9.64626  ? 267 ILE   A CG1 1 
ATOM   1442 C  CG2 . ILE   A 1 267 ? -10.43171 2.81677   -34.71883 1.000 5.55473  ? 267 ILE   A CG2 1 
ATOM   1443 C  CD1 . ILE   A 1 267 ? -7.43753  3.37510   -35.79133 1.000 5.39415  ? 267 ILE   A CD1 1 
ATOM   1444 N  N   . VAL   A 1 268 ? -12.91199 3.73676   -36.95617 1.000 8.18320  ? 268 VAL   A N   1 
ATOM   1445 C  CA  . VAL   A 1 268 ? -14.27604 4.06469   -36.53385 1.000 8.94124  ? 268 VAL   A CA  1 
ATOM   1446 C  C   . VAL   A 1 268 ? -15.28878 3.14576   -37.21583 1.000 10.53817 ? 268 VAL   A C   1 
ATOM   1447 O  O   . VAL   A 1 268 ? -16.20902 2.62880   -36.57400 1.000 9.96835  ? 268 VAL   A O   1 
ATOM   1448 C  CB  . VAL   A 1 268 ? -14.60283 5.54318   -36.81106 1.000 6.84597  ? 268 VAL   A CB  1 
ATOM   1449 C  CG1 . VAL   A 1 268 ? -16.09746 5.82314   -36.52852 1.000 6.39576  ? 268 VAL   A CG1 1 
ATOM   1450 C  CG2 . VAL   A 1 268 ? -13.73414 6.45983   -35.96715 1.000 10.62866 ? 268 VAL   A CG2 1 
ATOM   1451 N  N   . LEU   A 1 269 ? -15.15386 2.95796   -38.53025 1.000 9.04247  ? 269 LEU   A N   1 
ATOM   1452 C  CA  . LEU   A 1 269 ? -16.09219 2.10446   -39.26448 1.000 12.36152 ? 269 LEU   A CA  1 
ATOM   1453 C  C   . LEU   A 1 269 ? -16.16597 0.70154   -38.67518 1.000 10.92713 ? 269 LEU   A C   1 
ATOM   1454 O  O   . LEU   A 1 269 ? -17.21078 0.05034   -38.77094 1.000 11.14406 ? 269 LEU   A O   1 
ATOM   1455 C  CB  . LEU   A 1 269 ? -15.71071 2.04566   -40.75115 1.000 9.76394  ? 269 LEU   A CB  1 
ATOM   1456 C  CG  . LEU   A 1 269 ? -16.11550 3.26659   -41.59694 1.000 10.23109 ? 269 LEU   A CG  1 
ATOM   1457 C  CD1 . LEU   A 1 269 ? -15.84325 3.12080   -43.14201 1.000 5.43275  ? 269 LEU   A CD1 1 
ATOM   1458 C  CD2 . LEU   A 1 269 ? -17.57872 3.59107   -41.35582 1.000 11.85513 ? 269 LEU   A CD2 1 
ATOM   1459 N  N   . ALA   A 1 270 ? -15.09441 0.24660   -38.01876 1.000 10.55386 ? 270 ALA   A N   1 
ATOM   1460 C  CA  . ALA   A 1 270 ? -15.01999 -1.06516  -37.37299 1.000 12.47764 ? 270 ALA   A CA  1 
ATOM   1461 C  C   . ALA   A 1 270 ? -15.68712 -1.11658  -36.00587 1.000 14.69992 ? 270 ALA   A C   1 
ATOM   1462 O  O   . ALA   A 1 270 ? -15.74140 -2.20702  -35.41492 1.000 8.40325  ? 270 ALA   A O   1 
ATOM   1463 C  CB  . ALA   A 1 270 ? -13.55687 -1.51362  -37.21018 1.000 12.29266 ? 270 ALA   A CB  1 
ATOM   1464 N  N   . THR   A 1 271 ? -16.16587 0.01415   -35.46996 1.000 8.49618  ? 271 THR   A N   1 
ATOM   1465 C  CA  . THR   A 1 271 ? -16.95028 -0.05050  -34.23936 1.000 10.76864 ? 271 THR   A CA  1 
ATOM   1466 C  C   . THR   A 1 271 ? -18.41975 -0.36530  -34.49345 1.000 9.26318  ? 271 THR   A C   1 
ATOM   1467 O  O   . THR   A 1 271 ? -19.18379 -0.50681  -33.53191 1.000 8.56474  ? 271 THR   A O   1 
ATOM   1468 C  CB  . THR   A 1 271 ? -16.84752 1.26897   -33.44690 1.000 11.84205 ? 271 THR   A CB  1 
ATOM   1469 O  OG1 . THR   A 1 271 ? -17.38412 2.33477   -34.22444 1.000 6.68725  ? 271 THR   A OG1 1 
ATOM   1470 C  CG2 . THR   A 1 271 ? -15.40932 1.56877   -33.11027 1.000 5.83697  ? 271 THR   A CG2 1 
ATOM   1471 N  N   . ASP   A 1 272 ? -18.82404 -0.45853  -35.75600 1.000 9.09794  ? 272 ASP   A N   1 
ATOM   1472 C  CA  . ASP   A 1 272 ? -20.15302 -0.92858  -36.10909 1.000 10.77353 ? 272 ASP   A CA  1 
ATOM   1473 C  C   . ASP   A 1 272 ? -20.33685 -2.34228  -35.57065 1.000 13.74268 ? 272 ASP   A C   1 
ATOM   1474 O  O   . ASP   A 1 272 ? -19.57282 -3.24793  -35.91402 1.000 10.47812 ? 272 ASP   A O   1 
ATOM   1475 C  CB  . ASP   A 1 272 ? -20.29942 -0.89912  -37.63047 1.000 12.22565 ? 272 ASP   A CB  1 
ATOM   1476 C  CG  . ASP   A 1 272 ? -21.69600 -1.19016  -38.09809 1.000 12.67723 ? 272 ASP   A CG  1 
ATOM   1477 O  OD1 . ASP   A 1 272 ? -22.54337 -1.56124  -37.26750 1.000 16.14479 ? 272 ASP   A OD1 1 
ATOM   1478 O  OD2 . ASP   A 1 272 ? -21.93819 -1.06659  -39.31851 1.000 13.37159 ? 272 ASP   A OD2 1 
ATOM   1479 N  N   . MET   A 1 273 ? -21.33864 -2.53373  -34.70969 1.000 14.19758 ? 273 MET   A N   1 
ATOM   1480 C  CA  . MET   A 1 273 ? -21.53533 -3.85446  -34.12172 1.000 16.88957 ? 273 MET   A CA  1 
ATOM   1481 C  C   . MET   A 1 273 ? -21.91957 -4.90318  -35.15382 1.000 15.74732 ? 273 MET   A C   1 
ATOM   1482 O  O   . MET   A 1 273 ? -21.66188 -6.09401  -34.93117 1.000 17.00477 ? 273 MET   A O   1 
ATOM   1483 C  CB  . MET   A 1 273 ? -22.59262 -3.80575  -33.01786 1.000 21.86781 ? 273 MET   A CB  1 
ATOM   1484 C  CG  . MET   A 1 273 ? -22.10485 -3.10800  -31.74933 1.000 22.04476 ? 273 MET   A CG  1 
ATOM   1485 S  SD  . MET   A 1 273 ? -20.71042 -3.92106  -30.94266 1.000 22.64573 ? 273 MET   A SD  1 
ATOM   1486 C  CE  . MET   A 1 273 ? -21.28049 -5.62826  -30.93578 1.000 18.37239 ? 273 MET   A CE  1 
ATOM   1487 N  N   . SER   A 1 274 ? -22.51346 -4.50589  -36.27587 1.000 12.29579 ? 274 SER   A N   1 
ATOM   1488 C  CA  . SER   A 1 274 ? -22.81144 -5.51408  -37.28302 1.000 18.74615 ? 274 SER   A CA  1 
ATOM   1489 C  C   . SER   A 1 274 ? -21.55324 -6.10608  -37.89730 1.000 18.40557 ? 274 SER   A C   1 
ATOM   1490 O  O   . SER   A 1 274 ? -21.65597 -7.06441  -38.65844 1.000 27.15354 ? 274 SER   A O   1 
ATOM   1491 C  CB  . SER   A 1 274 ? -23.72964 -4.93940  -38.36804 1.000 22.77672 ? 274 SER   A CB  1 
ATOM   1492 O  OG  . SER   A 1 274 ? -23.30388 -3.65100  -38.76085 1.000 26.99782 ? 274 SER   A OG  1 
ATOM   1493 N  N   . LYS   A 1 275 ? -20.37140 -5.58948  -37.56573 1.000 16.12772 ? 275 LYS   A N   1 
ATOM   1494 C  CA  . LYS   A 1 275 ? -19.11635 -6.16194  -38.01930 1.000 14.43461 ? 275 LYS   A CA  1 
ATOM   1495 C  C   . LYS   A 1 275 ? -18.37776 -6.88583  -36.90945 1.000 12.84254 ? 275 LYS   A C   1 
ATOM   1496 O  O   . LYS   A 1 275 ? -17.21456 -7.26026  -37.09475 1.000 11.22629 ? 275 LYS   A O   1 
ATOM   1497 C  CB  . LYS   A 1 275 ? -18.21291 -5.07056  -38.61681 1.000 13.08192 ? 275 LYS   A CB  1 
ATOM   1498 C  CG  . LYS   A 1 275 ? -18.81030 -4.37675  -39.84686 1.000 15.57839 ? 275 LYS   A CG  1 
ATOM   1499 C  CD  . LYS   A 1 275 ? -17.97598 -3.18907  -40.24368 1.000 20.61335 ? 275 LYS   A CD  1 
ATOM   1500 C  CE  . LYS   A 1 275 ? -18.53988 -2.47721  -41.47537 1.000 17.61581 ? 275 LYS   A CE  1 
ATOM   1501 N  NZ  . LYS   A 1 275 ? -18.10864 -1.02956  -41.45491 1.000 18.89323 ? 275 LYS   A NZ  1 
ATOM   1502 N  N   . HIS   A 1 276 ? -19.01031 -7.08317  -35.75540 1.000 14.27406 ? 276 HIS   A N   1 
ATOM   1503 C  CA  . HIS   A 1 276 ? -18.30578 -7.71559  -34.64388 1.000 13.93160 ? 276 HIS   A CA  1 
ATOM   1504 C  C   . HIS   A 1 276 ? -17.83926 -9.11799  -35.00675 1.000 14.36568 ? 276 HIS   A C   1 
ATOM   1505 O  O   . HIS   A 1 276 ? -16.66205 -9.45643  -34.84487 1.000 16.61504 ? 276 HIS   A O   1 
ATOM   1506 C  CB  . HIS   A 1 276 ? -19.19056 -7.77139  -33.41240 1.000 9.75444  ? 276 HIS   A CB  1 
ATOM   1507 C  CG  . HIS   A 1 276 ? -18.64384 -8.65363  -32.34029 1.000 12.89259 ? 276 HIS   A CG  1 
ATOM   1508 N  ND1 . HIS   A 1 276 ? -17.65601 -8.24162  -31.47435 1.000 15.35517 ? 276 HIS   A ND1 1 
ATOM   1509 C  CD2 . HIS   A 1 276 ? -18.91790 -9.93863  -32.01324 1.000 13.52324 ? 276 HIS   A CD2 1 
ATOM   1510 C  CE1 . HIS   A 1 276 ? -17.36029 -9.22337  -30.64305 1.000 11.38690 ? 276 HIS   A CE1 1 
ATOM   1511 N  NE2 . HIS   A 1 276 ? -18.10940 -10.26510 -30.95122 1.000 15.43442 ? 276 HIS   A NE2 1 
ATOM   1512 N  N   . MET   A 1 277 ? -18.76250 -9.96732  -35.46539 1.000 17.86633 ? 277 MET   A N   1 
ATOM   1513 C  CA  . MET   A 1 277 ? -18.40434 -11.36329 -35.70390 1.000 22.87164 ? 277 MET   A CA  1 
ATOM   1514 C  C   . MET   A 1 277 ? -17.23753 -11.47008 -36.67623 1.000 16.50039 ? 277 MET   A C   1 
ATOM   1515 O  O   . MET   A 1 277 ? -16.31757 -12.25903 -36.45793 1.000 17.17815 ? 277 MET   A O   1 
ATOM   1516 C  CB  . MET   A 1 277 ? -19.61700 -12.15237 -36.21454 1.000 19.10605 ? 277 MET   A CB  1 
ATOM   1517 C  CG  . MET   A 1 277 ? -20.67038 -12.44894 -35.14680 1.000 24.18744 ? 277 MET   A CG  1 
ATOM   1518 S  SD  . MET   A 1 277 ? -20.03557 -13.22969 -33.63386 1.000 36.88199 ? 277 MET   A SD  1 
ATOM   1519 C  CE  . MET   A 1 277 ? -21.57073 -13.57921 -32.76379 1.000 26.51855 ? 277 MET   A CE  1 
ATOM   1520 N  N   . ASN   A 1 278 ? -17.24200 -10.66206 -37.73751 1.000 13.31299 ? 278 ASN   A N   1 
ATOM   1521 C  CA  . ASN   A 1 278 ? -16.16269 -10.72614 -38.72345 1.000 19.99095 ? 278 ASN   A CA  1 
ATOM   1522 C  C   . ASN   A 1 278 ? -14.85247 -10.24011 -38.12850 1.000 18.10904 ? 278 ASN   A C   1 
ATOM   1523 O  O   . ASN   A 1 278 ? -13.79971 -10.87162 -38.28884 1.000 19.42760 ? 278 ASN   A O   1 
ATOM   1524 C  CB  . ASN   A 1 278 ? -16.53233 -9.89972  -39.95417 1.000 20.75422 ? 278 ASN   A CB  1 
ATOM   1525 C  CG  . ASN   A 1 278 ? -17.27938 -10.71248 -40.98998 1.000 22.84386 ? 278 ASN   A CG  1 
ATOM   1526 O  OD1 . ASN   A 1 278 ? -18.50406 -10.70649 -41.03738 1.000 30.27526 ? 278 ASN   A OD1 1 
ATOM   1527 N  ND2 . ASN   A 1 278 ? -16.54052 -11.40882 -41.83181 1.000 32.14959 ? 278 ASN   A ND2 1 
ATOM   1528 N  N   . LEU   A 1 279 ? -14.90784 -9.12683  -37.41375 1.000 16.32256 ? 279 LEU   A N   1 
ATOM   1529 C  CA  . LEU   A 1 279 ? -13.71167 -8.59147  -36.79775 1.000 16.31606 ? 279 LEU   A CA  1 
ATOM   1530 C  C   . LEU   A 1 279 ? -13.14959 -9.57349  -35.78220 1.000 16.13535 ? 279 LEU   A C   1 
ATOM   1531 O  O   . LEU   A 1 279 ? -11.93368 -9.78087  -35.71686 1.000 17.52095 ? 279 LEU   A O   1 
ATOM   1532 C  CB  . LEU   A 1 279 ? -14.04284 -7.25023  -36.15965 1.000 17.62288 ? 279 LEU   A CB  1 
ATOM   1533 C  CG  . LEU   A 1 279 ? -12.91708 -6.24404  -36.00510 1.000 20.68478 ? 279 LEU   A CG  1 
ATOM   1534 C  CD1 . LEU   A 1 279 ? -12.39083 -5.86527  -37.36278 1.000 13.29806 ? 279 LEU   A CD1 1 
ATOM   1535 C  CD2 . LEU   A 1 279 ? -13.48423 -5.01798  -35.27788 1.000 20.24096 ? 279 LEU   A CD2 1 
ATOM   1536 N  N   . LEU   A 1 280 ? -14.01880 -10.19569 -34.98428 1.000 14.89263 ? 280 LEU   A N   1 
ATOM   1537 C  CA  . LEU   A 1 280 ? -13.55065 -11.23300 -34.07397 1.000 15.64288 ? 280 LEU   A CA  1 
ATOM   1538 C  C   . LEU   A 1 280 ? -12.97381 -12.41382 -34.85162 1.000 19.12840 ? 280 LEU   A C   1 
ATOM   1539 O  O   . LEU   A 1 280 ? -11.90202 -12.92316 -34.51238 1.000 18.12891 ? 280 LEU   A O   1 
ATOM   1540 C  CB  . LEU   A 1 280 ? -14.69099 -11.69011 -33.15907 1.000 14.96260 ? 280 LEU   A CB  1 
ATOM   1541 C  CG  . LEU   A 1 280 ? -14.41167 -12.82338 -32.16365 1.000 14.34585 ? 280 LEU   A CG  1 
ATOM   1542 C  CD1 . LEU   A 1 280 ? -13.16410 -12.55731 -31.33719 1.000 10.82912 ? 280 LEU   A CD1 1 
ATOM   1543 C  CD2 . LEU   A 1 280 ? -15.61063 -13.03642 -31.26422 1.000 14.16056 ? 280 LEU   A CD2 1 
ATOM   1544 N  N   . ALA   A 1 281 ? -13.66414 -12.84715 -35.91141 1.000 19.82723 ? 281 ALA   A N   1 
ATOM   1545 C  CA  . ALA   A 1 281 ? -13.16862 -13.95653 -36.71820 1.000 19.13109 ? 281 ALA   A CA  1 
ATOM   1546 C  C   . ALA   A 1 281 ? -11.75939 -13.68023 -37.21942 1.000 21.99437 ? 281 ALA   A C   1 
ATOM   1547 O  O   . ALA   A 1 281 ? -10.86934 -14.53167 -37.12212 1.000 18.21561 ? 281 ALA   A O   1 
ATOM   1548 C  CB  . ALA   A 1 281 ? -14.11349 -14.21669 -37.88945 1.000 18.18034 ? 281 ALA   A CB  1 
ATOM   1549 N  N   . ASP   A 1 282 ? -11.53506 -12.48082 -37.75033 1.000 22.52089 ? 282 ASP   A N   1 
ATOM   1550 C  CA  . ASP   A 1 282 ? -10.21193 -12.15752 -38.25965 1.000 17.80562 ? 282 ASP   A CA  1 
ATOM   1551 C  C   . ASP   A 1 282 ? -9.19726  -12.04365 -37.12947 1.000 22.98783 ? 282 ASP   A C   1 
ATOM   1552 O  O   . ASP   A 1 282 ? -8.01823  -12.38897 -37.30424 1.000 21.11488 ? 282 ASP   A O   1 
ATOM   1553 C  CB  . ASP   A 1 282 ? -10.29256 -10.87457 -39.08146 1.000 24.17367 ? 282 ASP   A CB  1 
ATOM   1554 C  CG  . ASP   A 1 282 ? -10.85181 -11.10852 -40.46781 1.000 34.64744 ? 282 ASP   A CG  1 
ATOM   1555 O  OD1 . ASP   A 1 282 ? -10.89299 -12.28470 -40.90788 1.000 26.57593 ? 282 ASP   A OD1 1 
ATOM   1556 O  OD2 . ASP   A 1 282 ? -11.24518 -10.11713 -41.12304 1.000 34.92275 ? 282 ASP   A OD2 1 
ATOM   1557 N  N   . LEU   A 1 283 ? -9.64027  -11.59893 -35.95539 1.000 17.59270 ? 283 LEU   A N   1 
ATOM   1558 C  CA  . LEU   A 1 283 ? -8.73276  -11.50121 -34.82382 1.000 19.30421 ? 283 LEU   A CA  1 
ATOM   1559 C  C   . LEU   A 1 283 ? -8.28920  -12.88352 -34.34834 1.000 24.91479 ? 283 LEU   A C   1 
ATOM   1560 O  O   . LEU   A 1 283 ? -7.10499  -13.10328 -34.06541 1.000 26.32231 ? 283 LEU   A O   1 
ATOM   1561 C  CB  . LEU   A 1 283 ? -9.40294  -10.73439 -33.69434 1.000 17.97888 ? 283 LEU   A CB  1 
ATOM   1562 C  CG  . LEU   A 1 283 ? -8.38266  -10.47975 -32.60732 1.000 15.86656 ? 283 LEU   A CG  1 
ATOM   1563 C  CD1 . LEU   A 1 283 ? -7.44351  -9.43313  -33.14649 1.000 23.31755 ? 283 LEU   A CD1 1 
ATOM   1564 C  CD2 . LEU   A 1 283 ? -9.09802  -10.02684 -31.34221 1.000 22.09895 ? 283 LEU   A CD2 1 
ATOM   1565 N  N   . LYS   A 1 284 ? -9.23380  -13.82108 -34.22367 1.000 18.20685 ? 284 LYS   A N   1 
ATOM   1566 C  CA  . LYS   A 1 284 ? -8.87866  -15.21246 -33.94552 1.000 19.81308 ? 284 LYS   A CA  1 
ATOM   1567 C  C   . LYS   A 1 284 ? -7.85770  -15.74200 -34.95176 1.000 23.22808 ? 284 LYS   A C   1 
ATOM   1568 O  O   . LYS   A 1 284 ? -6.88597  -16.40454 -34.57654 1.000 26.87559 ? 284 LYS   A O   1 
ATOM   1569 C  CB  . LYS   A 1 284 ? -10.13293 -16.08823 -33.96265 1.000 18.06907 ? 284 LYS   A CB  1 
ATOM   1570 C  CG  . LYS   A 1 284 ? -10.85314 -16.16995 -32.63889 1.000 24.97345 ? 284 LYS   A CG  1 
ATOM   1571 C  CD  . LYS   A 1 284 ? -12.09611 -17.04679 -32.70828 1.000 16.75106 ? 284 LYS   A CD  1 
ATOM   1572 C  CE  . LYS   A 1 284 ? -13.00425 -16.75720 -31.50772 1.000 18.47932 ? 284 LYS   A CE  1 
ATOM   1573 N  NZ  . LYS   A 1 284 ? -14.41012 -17.21161 -31.76062 1.000 29.96405 ? 284 LYS   A NZ  1 
ATOM   1574 N  N   . THR   A 1 285 ? -8.07573  -15.48060 -36.24362 1.000 21.52906 ? 285 THR   A N   1 
ATOM   1575 C  CA  . THR   A 1 285 ? -7.11575  -15.93010 -37.24898 1.000 18.43707 ? 285 THR   A CA  1 
ATOM   1576 C  C   . THR   A 1 285 ? -5.73437  -15.34101 -36.98788 1.000 25.53109 ? 285 THR   A C   1 
ATOM   1577 O  O   . THR   A 1 285 ? -4.71898  -16.03685 -37.10398 1.000 27.32087 ? 285 THR   A O   1 
ATOM   1578 C  CB  . THR   A 1 285 ? -7.59964  -15.56307 -38.65041 1.000 21.88031 ? 285 THR   A CB  1 
ATOM   1579 O  OG1 . THR   A 1 285 ? -8.80988  -16.26991 -38.93890 1.000 22.88210 ? 285 THR   A OG1 1 
ATOM   1580 C  CG2 . THR   A 1 285 ? -6.55155  -15.94668 -39.69504 1.000 24.15601 ? 285 THR   A CG2 1 
ATOM   1581 N  N   . MET   A 1 286 ? -5.67508  -14.06810 -36.60143 1.000 25.54562 ? 286 MET   A N   1 
ATOM   1582 C  CA  . MET   A 1 286 ? -4.38870  -13.47235 -36.26857 1.000 22.82727 ? 286 MET   A CA  1 
ATOM   1583 C  C   . MET   A 1 286 ? -3.74263  -14.16941 -35.08109 1.000 23.74274 ? 286 MET   A C   1 
ATOM   1584 O  O   . MET   A 1 286 ? -2.52472  -14.37355 -35.06499 1.000 26.39969 ? 286 MET   A O   1 
ATOM   1585 C  CB  . MET   A 1 286 ? -4.55007  -11.98640 -35.98105 1.000 20.64569 ? 286 MET   A CB  1 
ATOM   1586 C  CG  . MET   A 1 286 ? -3.32518  -11.40495 -35.29654 1.000 23.26545 ? 286 MET   A CG  1 
ATOM   1587 S  SD  . MET   A 1 286 ? -3.25904  -9.60901  -35.27232 1.000 27.13398 ? 286 MET   A SD  1 
ATOM   1588 C  CE  . MET   A 1 286 ? -3.75618  -9.15043  -36.93715 1.000 20.72476 ? 286 MET   A CE  1 
ATOM   1589 N  N   . VAL   A 1 287 ? -4.53593  -14.52950 -34.06813 1.000 27.66520 ? 287 VAL   A N   1 
ATOM   1590 C  CA  . VAL   A 1 287 ? -3.97985  -15.18857 -32.88679 1.000 24.05940 ? 287 VAL   A CA  1 
ATOM   1591 C  C   . VAL   A 1 287 ? -3.43684  -16.56230 -33.25902 1.000 22.58633 ? 287 VAL   A C   1 
ATOM   1592 O  O   . VAL   A 1 287 ? -2.37601  -16.97505 -32.78949 1.000 22.62384 ? 287 VAL   A O   1 
ATOM   1593 C  CB  . VAL   A 1 287 ? -5.04286  -15.28324 -31.77555 1.000 29.01451 ? 287 VAL   A CB  1 
ATOM   1594 C  CG1 . VAL   A 1 287 ? -4.53289  -16.13842 -30.59031 1.000 22.38410 ? 287 VAL   A CG1 1 
ATOM   1595 C  CG2 . VAL   A 1 287 ? -5.45130  -13.89091 -31.30603 1.000 23.46093 ? 287 VAL   A CG2 1 
ATOM   1596 N  N   . GLU   A 1 288 ? -4.15036  -17.27045 -34.13128 1.000 23.79952 ? 288 GLU   A N   1 
ATOM   1597 C  CA  . GLU   A 1 288 ? -3.74166  -18.58962 -34.59458 1.000 26.40202 ? 288 GLU   A CA  1 
ATOM   1598 C  C   . GLU   A 1 288 ? -2.40787  -18.54983 -35.33162 1.000 28.38986 ? 288 GLU   A C   1 
ATOM   1599 O  O   . GLU   A 1 288 ? -1.65370  -19.53100 -35.30064 1.000 25.40904 ? 288 GLU   A O   1 
ATOM   1600 C  CB  . GLU   A 1 288 ? -4.83802  -19.15248 -35.49926 1.000 25.89311 ? 288 GLU   A CB  1 
ATOM   1601 C  CG  . GLU   A 1 288 ? -4.96982  -20.65531 -35.51477 1.000 38.05090 ? 288 GLU   A CG  1 
ATOM   1602 C  CD  . GLU   A 1 288 ? -4.60691  -21.28673 -34.18667 1.000 39.56166 ? 288 GLU   A CD  1 
ATOM   1603 O  OE1 . GLU   A 1 288 ? -5.26277  -20.96286 -33.16812 1.000 37.35001 ? 288 GLU   A OE1 1 
ATOM   1604 O  OE2 . GLU   A 1 288 ? -3.65592  -22.10366 -34.15651 1.000 35.64236 ? 288 GLU   A OE2 1 
ATOM   1605 N  N   . THR   A 1 289 ? -2.09920  -17.42751 -35.98769 1.000 20.47598 ? 289 THR   A N   1 
ATOM   1606 C  CA  . THR   A 1 289 ? -0.92682  -17.28792 -36.84565 1.000 22.78921 ? 289 THR   A CA  1 
ATOM   1607 C  C   . THR   A 1 289 ? 0.03855   -16.24143 -36.31057 1.000 25.58897 ? 289 THR   A C   1 
ATOM   1608 O  O   . THR   A 1 289 ? 0.87418   -15.72466 -37.05395 1.000 24.50474 ? 289 THR   A O   1 
ATOM   1609 C  CB  . THR   A 1 289 ? -1.36848  -16.92531 -38.25470 1.000 19.97113 ? 289 THR   A CB  1 
ATOM   1610 O  OG1 . THR   A 1 289 ? -2.07253  -15.67945 -38.19345 1.000 20.88142 ? 289 THR   A OG1 1 
ATOM   1611 C  CG2 . THR   A 1 289 ? -2.29723  -17.99132 -38.78721 1.000 15.27641 ? 289 THR   A CG2 1 
ATOM   1612 N  N   . LYS   A 1 290 ? -0.07909  -15.93972 -35.02078 1.000 34.74630 ? 290 LYS   A N   1 
ATOM   1613 C  CA  . LYS   A 1 290 ? 0.65345   -14.87209 -34.35526 1.000 30.41020 ? 290 LYS   A CA  1 
ATOM   1614 C  C   . LYS   A 1 290 ? 2.16223   -15.02839 -34.54854 1.000 37.41067 ? 290 LYS   A C   1 
ATOM   1615 O  O   . LYS   A 1 290 ? 2.68887   -16.14372 -34.61537 1.000 33.66501 ? 290 LYS   A O   1 
ATOM   1616 C  CB  . LYS   A 1 290 ? 0.23858   -14.91230 -32.87234 1.000 30.48973 ? 290 LYS   A CB  1 
ATOM   1617 C  CG  . LYS   A 1 290 ? 1.05288   -14.18402 -31.81837 1.000 36.75509 ? 290 LYS   A CG  1 
ATOM   1618 C  CD  . LYS   A 1 290 ? 0.22067   -14.18433 -30.51372 1.000 36.65959 ? 290 LYS   A CD  1 
ATOM   1619 C  CE  . LYS   A 1 290 ? 1.03748   -14.11356 -29.23083 1.000 34.34451 ? 290 LYS   A CE  1 
ATOM   1620 N  NZ  . LYS   A 1 290 ? 1.76766   -12.82667 -29.02393 1.000 33.44149 ? 290 LYS   A NZ  1 
ATOM   1621 N  N   . LYS   A 1 291 ? 2.85249   -13.89633 -34.68484 1.000 40.63148 ? 291 LYS   A N   1 
ATOM   1622 C  CA  . LYS   A 1 291 ? 4.30658   -13.88197 -34.79217 1.000 39.59087 ? 291 LYS   A CA  1 
ATOM   1623 C  C   . LYS   A 1 291 ? 4.86256   -12.78779 -33.90138 1.000 35.77356 ? 291 LYS   A C   1 
ATOM   1624 O  O   . LYS   A 1 291 ? 4.33656   -11.66930 -33.88741 1.000 37.42806 ? 291 LYS   A O   1 
ATOM   1625 C  CB  . LYS   A 1 291 ? 4.76567   -13.66916 -36.23764 1.000 31.59741 ? 291 LYS   A CB  1 
ATOM   1626 C  CG  . LYS   A 1 291 ? 4.50628   -14.87503 -37.10412 1.000 32.20229 ? 291 LYS   A CG  1 
ATOM   1627 C  CD  . LYS   A 1 291 ? 4.81773   -14.58109 -38.55767 1.000 47.44336 ? 291 LYS   A CD  1 
ATOM   1628 C  CE  . LYS   A 1 291 ? 5.82821   -15.57725 -39.13337 1.000 31.74262 ? 291 LYS   A CE  1 
ATOM   1629 N  NZ  . LYS   A 1 291 ? 5.79464   -15.53420 -40.62347 1.000 31.28459 ? 291 LYS   A NZ  1 
ATOM   1630 N  N   . VAL   A 1 292 ? 5.91974   -13.11966 -33.16550 1.000 37.34858 ? 292 VAL   A N   1 
ATOM   1631 C  CA  . VAL   A 1 292 ? 6.57899   -12.18498 -32.26902 1.000 41.93831 ? 292 VAL   A CA  1 
ATOM   1632 C  C   . VAL   A 1 292 ? 7.92525   -11.79641 -32.86770 1.000 44.11106 ? 292 VAL   A C   1 
ATOM   1633 O  O   . VAL   A 1 292 ? 8.38490   -12.37408 -33.85184 1.000 49.99493 ? 292 VAL   A O   1 
ATOM   1634 C  CB  . VAL   A 1 292 ? 6.75284   -12.76175 -30.84878 1.000 46.30407 ? 292 VAL   A CB  1 
ATOM   1635 C  CG1 . VAL   A 1 292 ? 5.42327   -12.81189 -30.13425 1.000 38.49266 ? 292 VAL   A CG1 1 
ATOM   1636 C  CG2 . VAL   A 1 292 ? 7.38295   -14.14916 -30.90598 1.000 49.93473 ? 292 VAL   A CG2 1 
ATOM   1637 N  N   . THR   A 1 293 ? 8.55453   -10.79169 -32.26227 1.000 45.21531 ? 293 THR   A N   1 
ATOM   1638 C  CA  . THR   A 1 293 ? 9.88422   -10.35270 -32.64645 1.000 46.56385 ? 293 THR   A CA  1 
ATOM   1639 C  C   . THR   A 1 293 ? 10.92128  -10.97712 -31.72130 1.000 54.70822 ? 293 THR   A C   1 
ATOM   1640 O  O   . THR   A 1 293 ? 10.60768  -11.78288 -30.83879 1.000 58.14191 ? 293 THR   A O   1 
ATOM   1641 C  CB  . THR   A 1 293 ? 9.99710   -8.82779  -32.60799 1.000 36.62994 ? 293 THR   A CB  1 
ATOM   1642 O  OG1 . THR   A 1 293 ? 9.65406   -8.35177  -31.29737 1.000 42.55579 ? 293 THR   A OG1 1 
ATOM   1643 C  CG2 . THR   A 1 293 ? 9.07954   -8.20178  -33.63663 1.000 39.65868 ? 293 THR   A CG2 1 
ATOM   1644 N  N   . SER   A 1 294 ? 12.18357  -10.59092 -31.93487 1.000 53.40664 ? 294 SER   A N   1 
ATOM   1645 C  CA  . SER   A 1 294 ? 13.23754  -10.95795 -30.99759 1.000 52.67095 ? 294 SER   A CA  1 
ATOM   1646 C  C   . SER   A 1 294 ? 12.98382  -10.35347 -29.62085 1.000 48.64731 ? 294 SER   A C   1 
ATOM   1647 O  O   . SER   A 1 294 ? 13.30709  -10.97208 -28.60153 1.000 50.75307 ? 294 SER   A O   1 
ATOM   1648 C  CB  . SER   A 1 294 ? 14.59658  -10.51883 -31.54678 1.000 58.47561 ? 294 SER   A CB  1 
ATOM   1649 O  OG  . SER   A 1 294 ? 14.54925  -9.17431  -31.99748 1.000 59.56659 ? 294 SER   A OG  1 
ATOM   1650 N  N   . SER   A 1 295 ? 12.39264  -9.15832  -29.56607 1.000 48.89218 ? 295 SER   A N   1 
ATOM   1651 C  CA  . SER   A 1 295 ? 11.98426  -8.60259  -28.28117 1.000 47.77282 ? 295 SER   A CA  1 
ATOM   1652 C  C   . SER   A 1 295 ? 10.75640  -9.28649  -27.70245 1.000 46.01312 ? 295 SER   A C   1 
ATOM   1653 O  O   . SER   A 1 295 ? 10.36614  -8.95075  -26.57910 1.000 54.28787 ? 295 SER   A O   1 
ATOM   1654 C  CB  . SER   A 1 295 ? 11.71651  -7.10408  -28.40678 1.000 49.32608 ? 295 SER   A CB  1 
ATOM   1655 O  OG  . SER   A 1 295 ? 10.83601  -6.82514  -29.48466 1.000 51.17854 ? 295 SER   A OG  1 
ATOM   1656 N  N   . GLY   A 1 296 ? 10.15134  -10.23825 -28.41391 1.000 48.76299 ? 296 GLY   A N   1 
ATOM   1657 C  CA  . GLY   A 1 296 ? 8.94941   -10.89160 -27.93159 1.000 43.97684 ? 296 GLY   A CA  1 
ATOM   1658 C  C   . GLY   A 1 296 ? 7.69387   -10.08057 -28.12010 1.000 44.80345 ? 296 GLY   A C   1 
ATOM   1659 O  O   . GLY   A 1 296 ? 6.62739   -10.48146 -27.64200 1.000 38.88859 ? 296 GLY   A O   1 
ATOM   1660 N  N   . VAL   A 1 297 ? 7.79632   -8.97300  -28.79936 1.000 45.32912 ? 297 VAL   A N   1 
ATOM   1661 C  CA  . VAL   A 1 297 ? 6.70507   -8.05449  -29.07615 1.000 36.00831 ? 297 VAL   A CA  1 
ATOM   1662 C  C   . VAL   A 1 297 ? 6.05305   -8.44394  -30.40225 1.000 37.42756 ? 297 VAL   A C   1 
ATOM   1663 O  O   . VAL   A 1 297 ? 6.68098   -9.05585  -31.27189 1.000 30.19967 ? 297 VAL   A O   1 
ATOM   1664 C  CB  . VAL   A 1 297 ? 7.26411   -6.61353  -29.07394 1.000 36.82989 ? 297 VAL   A CB  1 
ATOM   1665 C  CG1 . VAL   A 1 297 ? 6.72691   -5.82437  -30.20572 1.000 31.61440 ? 297 VAL   A CG1 1 
ATOM   1666 C  CG2 . VAL   A 1 297 ? 6.99925   -5.91718  -27.73471 1.000 30.87121 ? 297 VAL   A CG2 1 
ATOM   1667 N  N   . LEU   A 1 298 ? 4.77146   -8.09960  -30.54690 1.000 32.57434 ? 298 LEU   A N   1 
ATOM   1668 C  CA  . LEU   A 1 298 ? 3.97047   -8.52493  -31.68746 1.000 28.23288 ? 298 LEU   A CA  1 
ATOM   1669 C  C   . LEU   A 1 298 ? 4.53092   -7.98217  -32.99970 1.000 23.35871 ? 298 LEU   A C   1 
ATOM   1670 O  O   . LEU   A 1 298 ? 4.95340   -6.82926  -33.08931 1.000 29.64109 ? 298 LEU   A O   1 
ATOM   1671 C  CB  . LEU   A 1 298 ? 2.53340   -8.05249  -31.47830 1.000 25.63156 ? 298 LEU   A CB  1 
ATOM   1672 C  CG  . LEU   A 1 298 ? 1.36932   -8.58110  -32.30690 1.000 33.81969 ? 298 LEU   A CG  1 
ATOM   1673 C  CD1 . LEU   A 1 298 ? 1.28918   -10.11831 -32.30020 1.000 28.56854 ? 298 LEU   A CD1 1 
ATOM   1674 C  CD2 . LEU   A 1 298 ? 0.07998   -7.96289  -31.77367 1.000 26.81585 ? 298 LEU   A CD2 1 
ATOM   1675 N  N   . LEU   A 1 299 ? 4.50602   -8.80978  -34.03505 1.000 25.18743 ? 299 LEU   A N   1 
ATOM   1676 C  CA  . LEU   A 1 299 ? 5.12114   -8.48935  -35.31904 1.000 28.24424 ? 299 LEU   A CA  1 
ATOM   1677 C  C   . LEU   A 1 299 ? 4.04272   -8.16143  -36.34484 1.000 23.56952 ? 299 LEU   A C   1 
ATOM   1678 O  O   . LEU   A 1 299 ? 3.24667   -9.03118  -36.71607 1.000 24.80307 ? 299 LEU   A O   1 
ATOM   1679 C  CB  . LEU   A 1 299 ? 5.97324   -9.66457  -35.79516 1.000 29.78230 ? 299 LEU   A CB  1 
ATOM   1680 C  CG  . LEU   A 1 299 ? 6.65767   -9.56055  -37.14533 1.000 35.39359 ? 299 LEU   A CG  1 
ATOM   1681 C  CD1 . LEU   A 1 299 ? 7.66251   -8.41906  -37.15526 1.000 32.49599 ? 299 LEU   A CD1 1 
ATOM   1682 C  CD2 . LEU   A 1 299 ? 7.32951   -10.89150 -37.46084 1.000 38.80360 ? 299 LEU   A CD2 1 
ATOM   1683 N  N   . LEU   A 1 300 ? 4.02836   -6.92510  -36.83086 1.000 24.81926 ? 300 LEU   A N   1 
ATOM   1684 C  CA  . LEU   A 1 300 ? 2.94841   -6.47442  -37.71160 1.000 25.73865 ? 300 LEU   A CA  1 
ATOM   1685 C  C   . LEU   A 1 300 ? 3.55635   -5.83743  -38.95827 1.000 26.30844 ? 300 LEU   A C   1 
ATOM   1686 O  O   . LEU   A 1 300 ? 3.94664   -4.66264  -38.94856 1.000 28.55559 ? 300 LEU   A O   1 
ATOM   1687 C  CB  . LEU   A 1 300 ? 1.99451   -5.53476  -36.96907 1.000 25.24483 ? 300 LEU   A CB  1 
ATOM   1688 C  CG  . LEU   A 1 300 ? 1.41113   -6.17408  -35.69199 1.000 25.63104 ? 300 LEU   A CG  1 
ATOM   1689 C  CD1 . LEU   A 1 300 ? 0.65506   -5.15817  -34.79960 1.000 21.77933 ? 300 LEU   A CD1 1 
ATOM   1690 C  CD2 . LEU   A 1 300 ? 0.52568   -7.37082  -36.03831 1.000 19.11313 ? 300 LEU   A CD2 1 
ATOM   1691 N  N   . ASP   A 1 301 ? 3.58224   -6.63750  -40.03458 1.000 31.63058 ? 301 ASP   A N   1 
ATOM   1692 C  CA  . ASP   A 1 301 ? 4.36115   -6.39683  -41.24958 1.000 28.83908 ? 301 ASP   A CA  1 
ATOM   1693 C  C   . ASP   A 1 301 ? 3.80096   -5.29634  -42.11932 1.000 24.33397 ? 301 ASP   A C   1 
ATOM   1694 O  O   . ASP   A 1 301 ? 4.51904   -4.77923  -42.97864 1.000 26.86323 ? 301 ASP   A O   1 
ATOM   1695 C  CB  . ASP   A 1 301 ? 4.38667   -7.66384  -42.11656 1.000 29.06390 ? 301 ASP   A CB  1 
ATOM   1696 C  CG  . ASP   A 1 301 ? 5.65647   -8.43252  -41.98514 1.000 34.78782 ? 301 ASP   A CG  1 
ATOM   1697 O  OD1 . ASP   A 1 301 ? 6.32355   -8.30501  -40.93854 1.000 38.53379 ? 301 ASP   A OD1 1 
ATOM   1698 O  OD2 . ASP   A 1 301 ? 5.99402   -9.16934  -42.93762 1.000 45.14648 ? 301 ASP   A OD2 1 
ATOM   1699 N  N   . ASN   A 1 302 ? 2.52972   -4.96019  -41.95773 1.000 31.50619 ? 302 ASN   A N   1 
ATOM   1700 C  CA  . ASN   A 1 302 ? 1.80321   -4.35567  -43.06058 1.000 30.62847 ? 302 ASN   A CA  1 
ATOM   1701 C  C   . ASN   A 1 302 ? 0.54572   -3.68168  -42.53771 1.000 28.30835 ? 302 ASN   A C   1 
ATOM   1702 O  O   . ASN   A 1 302 ? 0.05656   -3.99925  -41.44641 1.000 22.51121 ? 302 ASN   A O   1 
ATOM   1703 C  CB  . ASN   A 1 302 ? 1.43605   -5.42293  -44.08729 1.000 24.01881 ? 302 ASN   A CB  1 
ATOM   1704 C  CG  . ASN   A 1 302 ? 0.56844   -6.50568  -43.48962 1.000 25.18960 ? 302 ASN   A CG  1 
ATOM   1705 O  OD1 . ASN   A 1 302 ? -0.62707  -6.30630  -43.26883 1.000 31.18903 ? 302 ASN   A OD1 1 
ATOM   1706 N  ND2 . ASN   A 1 302 ? 1.16321   -7.65027  -43.20286 1.000 23.66757 ? 302 ASN   A ND2 1 
ATOM   1707 N  N   . TYR   A 1 303 ? 0.01163   -2.77408  -43.36405 1.000 17.70126 ? 303 TYR   A N   1 
ATOM   1708 C  CA  . TYR   A 1 303 ? -1.16409  -2.01465  -42.97978 1.000 19.62041 ? 303 TYR   A CA  1 
ATOM   1709 C  C   . TYR   A 1 303 ? -2.29427  -2.92954  -42.54105 1.000 20.84337 ? 303 TYR   A C   1 
ATOM   1710 O  O   . TYR   A 1 303 ? -2.91007  -2.71435  -41.48910 1.000 18.13000 ? 303 TYR   A O   1 
ATOM   1711 C  CB  . TYR   A 1 303 ? -1.63359  -1.13729  -44.13122 1.000 20.02838 ? 303 TYR   A CB  1 
ATOM   1712 C  CG  . TYR   A 1 303 ? -2.76059  -0.26547  -43.68977 1.000 19.95300 ? 303 TYR   A CG  1 
ATOM   1713 C  CD1 . TYR   A 1 303 ? -2.53057  0.75249   -42.77626 1.000 26.13283 ? 303 TYR   A CD1 1 
ATOM   1714 C  CD2 . TYR   A 1 303 ? -4.05730  -0.47133  -44.13562 1.000 20.37448 ? 303 TYR   A CD2 1 
ATOM   1715 C  CE1 . TYR   A 1 303 ? -3.54199  1.56670   -42.34080 1.000 17.26324 ? 303 TYR   A CE1 1 
ATOM   1716 C  CE2 . TYR   A 1 303 ? -5.09626  0.35214   -43.69488 1.000 19.15218 ? 303 TYR   A CE2 1 
ATOM   1717 C  CZ  . TYR   A 1 303 ? -4.81962  1.36815   -42.78370 1.000 17.12528 ? 303 TYR   A CZ  1 
ATOM   1718 O  OH  . TYR   A 1 303 ? -5.79785  2.22594   -42.31345 1.000 17.40507 ? 303 TYR   A OH  1 
ATOM   1719 N  N   . SER   A 1 304 ? -2.57160  -3.96472  -43.33702 1.000 15.88083 ? 304 SER   A N   1 
ATOM   1720 C  CA  . SER   A 1 304 ? -3.69728  -4.84077  -43.04452 1.000 18.75759 ? 304 SER   A CA  1 
ATOM   1721 C  C   . SER   A 1 304 ? -3.64478  -5.36042  -41.60913 1.000 20.11609 ? 304 SER   A C   1 
ATOM   1722 O  O   . SER   A 1 304 ? -4.64394  -5.30617  -40.88706 1.000 20.83079 ? 304 SER   A O   1 
ATOM   1723 C  CB  . SER   A 1 304 ? -3.73678  -5.99319  -44.03708 1.000 17.93419 ? 304 SER   A CB  1 
ATOM   1724 O  OG  . SER   A 1 304 ? -4.99153  -6.64161  -43.98584 1.000 26.45451 ? 304 SER   A OG  1 
ATOM   1725 N  N   . ASP   A 1 305 ? -2.47870  -5.83228  -41.16530 1.000 18.22594 ? 305 ASP   A N   1 
ATOM   1726 C  CA  . ASP   A 1 305 ? -2.37529  -6.40173  -39.82088 1.000 23.15221 ? 305 ASP   A CA  1 
ATOM   1727 C  C   . ASP   A 1 305 ? -2.34381  -5.32526  -38.74925 1.000 17.35647 ? 305 ASP   A C   1 
ATOM   1728 O  O   . ASP   A 1 305 ? -2.89409  -5.51041  -37.65724 1.000 19.01771 ? 305 ASP   A O   1 
ATOM   1729 C  CB  . ASP   A 1 305 ? -1.12593  -7.26300  -39.69965 1.000 20.68449 ? 305 ASP   A CB  1 
ATOM   1730 C  CG  . ASP   A 1 305 ? -1.31780  -8.64546  -40.27226 1.000 22.75345 ? 305 ASP   A CG  1 
ATOM   1731 O  OD1 . ASP   A 1 305 ? -2.47059  -9.01866  -40.56741 1.000 21.82338 ? 305 ASP   A OD1 1 
ATOM   1732 O  OD2 . ASP   A 1 305 ? -0.31095  -9.36406  -40.40463 1.000 21.84377 ? 305 ASP   A OD2 1 
ATOM   1733 N  N   . ARG   A 1 306 ? -1.69661  -4.20583  -39.04600 1.000 14.68092 ? 306 ARG   A N   1 
ATOM   1734 C  CA  . ARG   A 1 306 ? -1.59550  -3.12729  -38.07386 1.000 21.49578 ? 306 ARG   A CA  1 
ATOM   1735 C  C   . ARG   A 1 306 ? -2.95589  -2.46965  -37.83165 1.000 21.05126 ? 306 ARG   A C   1 
ATOM   1736 O  O   . ARG   A 1 306 ? -3.34453  -2.24899  -36.67927 1.000 21.34288 ? 306 ARG   A O   1 
ATOM   1737 C  CB  . ARG   A 1 306 ? -0.56043  -2.11146  -38.54775 1.000 17.53890 ? 306 ARG   A CB  1 
ATOM   1738 C  CG  . ARG   A 1 306 ? 0.84946   -2.68704  -38.69632 1.000 24.44588 ? 306 ARG   A CG  1 
ATOM   1739 C  CD  . ARG   A 1 306 ? 1.76545   -1.78854  -39.55296 1.000 23.19869 ? 306 ARG   A CD  1 
ATOM   1740 N  NE  . ARG   A 1 306 ? 2.26062   -0.63175  -38.81458 1.000 23.13839 ? 306 ARG   A NE  1 
ATOM   1741 C  CZ  . ARG   A 1 306 ? 3.21307   -0.68332  -37.87993 1.000 31.65291 ? 306 ARG   A CZ  1 
ATOM   1742 N  NH1 . ARG   A 1 306 ? 3.78462   -1.84462  -37.56116 1.000 21.53357 ? 306 ARG   A NH1 1 
ATOM   1743 N  NH2 . ARG   A 1 306 ? 3.59172   0.42854   -37.25167 1.000 22.40669 ? 306 ARG   A NH2 1 
ATOM   1744 N  N   . ILE   A 1 307 ? -3.70047  -2.15639  -38.90071 1.000 13.06529 ? 307 ILE   A N   1 
ATOM   1745 C  CA  . ILE   A 1 307 ? -5.00108  -1.52086  -38.69763 1.000 16.80106 ? 307 ILE   A CA  1 
ATOM   1746 C  C   . ILE   A 1 307 ? -5.96773  -2.51842  -38.07704 1.000 13.83528 ? 307 ILE   A C   1 
ATOM   1747 O  O   . ILE   A 1 307 ? -6.85496  -2.14876  -37.30241 1.000 13.24361 ? 307 ILE   A O   1 
ATOM   1748 C  CB  . ILE   A 1 307 ? -5.54137  -0.92536  -40.01842 1.000 13.69976 ? 307 ILE   A CB  1 
ATOM   1749 C  CG1 . ILE   A 1 307 ? -6.53058  0.21856   -39.74739 1.000 12.43908 ? 307 ILE   A CG1 1 
ATOM   1750 C  CG2 . ILE   A 1 307 ? -6.22404  -1.98595  -40.88919 1.000 19.01984 ? 307 ILE   A CG2 1 
ATOM   1751 C  CD1 . ILE   A 1 307 ? -5.91754  1.39710   -39.09205 1.000 10.46561 ? 307 ILE   A CD1 1 
ATOM   1752 N  N   . GLN   A 1 308 ? -5.77445  -3.80035  -38.35286 1.000 14.71317 ? 308 GLN   A N   1 
ATOM   1753 C  CA  . GLN   A 1 308 ? -6.64827  -4.80772  -37.78276 1.000 13.17985 ? 308 GLN   A CA  1 
ATOM   1754 C  C   . GLN   A 1 308 ? -6.51230  -4.84110  -36.26992 1.000 14.85249 ? 308 GLN   A C   1 
ATOM   1755 O  O   . GLN   A 1 308 ? -7.50115  -5.03578  -35.54485 1.000 13.95716 ? 308 GLN   A O   1 
ATOM   1756 C  CB  . GLN   A 1 308 ? -6.31852  -6.16128  -38.41188 1.000 15.97308 ? 308 GLN   A CB  1 
ATOM   1757 C  CG  . GLN   A 1 308 ? -7.05066  -7.34256  -37.84739 1.000 19.36514 ? 308 GLN   A CG  1 
ATOM   1758 C  CD  . GLN   A 1 308 ? -6.86078  -8.58526  -38.69064 1.000 25.16857 ? 308 GLN   A CD  1 
ATOM   1759 O  OE1 . GLN   A 1 308 ? -5.84837  -8.76228  -39.37417 1.000 22.75627 ? 308 GLN   A OE1 1 
ATOM   1760 N  NE2 . GLN   A 1 308 ? -7.83622  -9.46254  -38.63718 1.000 28.24188 ? 308 GLN   A NE2 1 
ATOM   1761 N  N   . VAL   A 1 309 ? -5.29445  -4.63221  -35.77917 1.000 14.83239 ? 309 VAL   A N   1 
ATOM   1762 C  CA  . VAL   A 1 309 ? -5.04214  -4.63036  -34.34491 1.000 14.32573 ? 309 VAL   A CA  1 
ATOM   1763 C  C   . VAL   A 1 309 ? -5.58697  -3.36077  -33.69783 1.000 12.81463 ? 309 VAL   A C   1 
ATOM   1764 O  O   . VAL   A 1 309 ? -6.15295  -3.40337  -32.59875 1.000 15.95384 ? 309 VAL   A O   1 
ATOM   1765 C  CB  . VAL   A 1 309 ? -3.53662  -4.80403  -34.08914 1.000 12.28127 ? 309 VAL   A CB  1 
ATOM   1766 C  CG1 . VAL   A 1 309 ? -3.19986  -4.45006  -32.65388 1.000 14.36449 ? 309 VAL   A CG1 1 
ATOM   1767 C  CG2 . VAL   A 1 309 ? -3.13058  -6.23560  -34.38657 1.000 12.99471 ? 309 VAL   A CG2 1 
ATOM   1768 N  N   . LEU   A 1 310 ? -5.42292  -2.21415  -34.35448 1.000 10.41714 ? 310 LEU   A N   1 
ATOM   1769 C  CA  . LEU   A 1 310 ? -6.03125  -0.98898  -33.84096 1.000 9.88213  ? 310 LEU   A CA  1 
ATOM   1770 C  C   . LEU   A 1 310 ? -7.56064  -1.04647  -33.92344 1.000 8.24502  ? 310 LEU   A C   1 
ATOM   1771 O  O   . LEU   A 1 310 ? -8.24806  -0.59674  -33.00508 1.000 7.77349  ? 310 LEU   A O   1 
ATOM   1772 C  CB  . LEU   A 1 310 ? -5.48248  0.22066   -34.60462 1.000 8.18173  ? 310 LEU   A CB  1 
ATOM   1773 C  CG  . LEU   A 1 310 ? -3.94695  0.39110   -34.53340 1.000 10.35896 ? 310 LEU   A CG  1 
ATOM   1774 C  CD1 . LEU   A 1 310 ? -3.48240  1.52609   -35.42596 1.000 11.67530 ? 310 LEU   A CD1 1 
ATOM   1775 C  CD2 . LEU   A 1 310 ? -3.46453  0.61033   -33.11642 1.000 11.34975 ? 310 LEU   A CD2 1 
ATOM   1776 N  N   . GLN   A 1 311 ? -8.11450  -1.61600  -34.99862 1.000 8.71059  ? 311 GLN   A N   1 
ATOM   1777 C  CA  . GLN   A 1 311 ? -9.57223  -1.77067  -35.07327 1.000 10.64208 ? 311 GLN   A CA  1 
ATOM   1778 C  C   . GLN   A 1 311 ? -10.08056 -2.56047  -33.88747 1.000 11.90160 ? 311 GLN   A C   1 
ATOM   1779 O  O   . GLN   A 1 311 ? -10.96950 -2.11658  -33.15758 1.000 12.00314 ? 311 GLN   A O   1 
ATOM   1780 C  CB  . GLN   A 1 311 ? -9.98433  -2.46029  -36.37571 1.000 7.18065  ? 311 GLN   A CB  1 
ATOM   1781 C  CG  . GLN   A 1 311 ? -9.91314  -1.57660  -37.58296 1.000 7.44937  ? 311 GLN   A CG  1 
ATOM   1782 C  CD  . GLN   A 1 311 ? -10.14391 -2.36324  -38.86805 1.000 12.00766 ? 311 GLN   A CD  1 
ATOM   1783 O  OE1 . GLN   A 1 311 ? -9.71444  -3.50245  -38.99143 1.000 8.99488  ? 311 GLN   A OE1 1 
ATOM   1784 N  NE2 . GLN   A 1 311 ? -10.82179 -1.75189  -39.82458 1.000 9.51029  ? 311 GLN   A NE2 1 
ATOM   1785 N  N   . ASN   A 1 312 ? -9.47511  -3.71671  -33.64752 1.000 13.27625 ? 312 ASN   A N   1 
ATOM   1786 C  CA  . ASN   A 1 312 ? -9.91754  -4.56920  -32.56752 1.000 13.83070 ? 312 ASN   A CA  1 
ATOM   1787 C  C   . ASN   A 1 312 ? -9.64089  -3.94612  -31.21635 1.000 10.43800 ? 312 ASN   A C   1 
ATOM   1788 O  O   . ASN   A 1 312 ? -10.38460 -4.19663  -30.26024 1.000 12.20229 ? 312 ASN   A O   1 
ATOM   1789 C  CB  . ASN   A 1 312 ? -9.23561  -5.92421  -32.70319 1.000 13.17933 ? 312 ASN   A CB  1 
ATOM   1790 C  CG  . ASN   A 1 312 ? -9.93064  -6.79038  -33.69760 1.000 18.56753 ? 312 ASN   A CG  1 
ATOM   1791 O  OD1 . ASN   A 1 312 ? -11.01983 -7.30818  -33.41791 1.000 18.58580 ? 312 ASN   A OD1 1 
ATOM   1792 N  ND2 . ASN   A 1 312 ? -9.34946  -6.92379  -34.88496 1.000 16.75977 ? 312 ASN   A ND2 1 
ATOM   1793 N  N   . MET   A 1 313 ? -8.58392  -3.13569  -31.12362 1.000 9.71104  ? 313 MET   A N   1 
ATOM   1794 C  CA  . MET   A 1 313 ? -8.25484  -2.47772  -29.86607 1.000 9.29758  ? 313 MET   A CA  1 
ATOM   1795 C  C   . MET   A 1 313 ? -9.35737  -1.51127  -29.45931 1.000 11.39548 ? 313 MET   A C   1 
ATOM   1796 O  O   . MET   A 1 313 ? -9.87997  -1.57803  -28.33792 1.000 13.41974 ? 313 MET   A O   1 
ATOM   1797 C  CB  . MET   A 1 313 ? -6.92262  -1.73869  -29.99387 1.000 9.37135  ? 313 MET   A CB  1 
ATOM   1798 C  CG  . MET   A 1 313 ? -6.54802  -0.99054  -28.75052 1.000 11.44993 ? 313 MET   A CG  1 
ATOM   1799 S  SD  . MET   A 1 313 ? -5.07238  0.01893   -28.94631 1.000 16.57206 ? 313 MET   A SD  1 
ATOM   1800 C  CE  . MET   A 1 313 ? -3.88246  -1.26031  -29.33766 1.000 7.84229  ? 313 MET   A CE  1 
ATOM   1801 N  N   . VAL   A 1 314 ? -9.72817  -0.60477  -30.37033 1.000 10.50981 ? 314 VAL   A N   1 
ATOM   1802 C  CA  . VAL   A 1 314 ? -10.76665 0.37417   -30.07468 1.000 10.49100 ? 314 VAL   A CA  1 
ATOM   1803 C  C   . VAL   A 1 314 ? -12.13012 -0.30979  -29.94162 1.000 10.88537 ? 314 VAL   A C   1 
ATOM   1804 O  O   . VAL   A 1 314 ? -12.97903 0.12779   -29.16266 1.000 7.18088  ? 314 VAL   A O   1 
ATOM   1805 C  CB  . VAL   A 1 314 ? -10.74383 1.46896   -31.15929 1.000 12.80922 ? 314 VAL   A CB  1 
ATOM   1806 C  CG1 . VAL   A 1 314 ? -11.94108 2.40444   -31.04404 1.000 7.07941  ? 314 VAL   A CG1 1 
ATOM   1807 C  CG2 . VAL   A 1 314 ? -9.41097  2.24270   -31.11528 1.000 8.54157  ? 314 VAL   A CG2 1 
ATOM   1808 N  N   . HIS   A 1 315 ? -12.34845 -1.39914  -30.67875 1.000 9.09337  ? 315 HIS   A N   1 
ATOM   1809 C  CA  . HIS   A 1 315 ? -13.54460 -2.21405  -30.49346 1.000 10.43220 ? 315 HIS   A CA  1 
ATOM   1810 C  C   . HIS   A 1 315 ? -13.59848 -2.81055  -29.08546 1.000 9.30541  ? 315 HIS   A C   1 
ATOM   1811 O  O   . HIS   A 1 315 ? -14.64925 -2.80128  -28.43373 1.000 9.69140  ? 315 HIS   A O   1 
ATOM   1812 C  CB  . HIS   A 1 315 ? -13.56934 -3.30777  -31.56677 1.000 7.59807  ? 315 HIS   A CB  1 
ATOM   1813 C  CG  . HIS   A 1 315 ? -14.77857 -4.18936  -31.52422 1.000 13.57230 ? 315 HIS   A CG  1 
ATOM   1814 N  ND1 . HIS   A 1 315 ? -16.06900 -3.69304  -31.50890 1.000 11.30892 ? 315 HIS   A ND1 1 
ATOM   1815 C  CD2 . HIS   A 1 315 ? -14.89366 -5.54021  -31.52241 1.000 8.66863  ? 315 HIS   A CD2 1 
ATOM   1816 C  CE1 . HIS   A 1 315 ? -16.92519 -4.70283  -31.48003 1.000 9.68502  ? 315 HIS   A CE1 1 
ATOM   1817 N  NE2 . HIS   A 1 315 ? -16.23716 -5.83288  -31.49322 1.000 10.75387 ? 315 HIS   A NE2 1 
ATOM   1818 N  N   . CYS   A 1 316 ? -12.47188 -3.34944  -28.60550 1.000 10.26643 ? 316 CYS   A N   1 
ATOM   1819 C  CA  . CYS   A 1 316 ? -12.39489 -3.86177  -27.23681 1.000 7.15304  ? 316 CYS   A CA  1 
ATOM   1820 C  C   . CYS   A 1 316 ? -12.65369 -2.77335  -26.22497 1.000 10.39792 ? 316 CYS   A C   1 
ATOM   1821 O  O   . CYS   A 1 316 ? -13.31062 -3.01073  -25.19792 1.000 8.45925  ? 316 CYS   A O   1 
ATOM   1822 C  CB  . CYS   A 1 316 ? -11.00967 -4.44040  -26.95874 1.000 12.19453 ? 316 CYS   A CB  1 
ATOM   1823 S  SG  . CYS   A 1 316 ? -10.77146 -6.07061  -27.58851 1.000 9.67722  ? 316 CYS   A SG  1 
ATOM   1824 N  N   . ALA   A 1 317 ? -12.07752 -1.58885  -26.46851 1.000 8.49273  ? 317 ALA   A N   1 
ATOM   1825 C  CA  . ALA   A 1 317 ? -12.28774 -0.45268  -25.58237 1.000 10.05255 ? 317 ALA   A CA  1 
ATOM   1826 C  C   . ALA   A 1 317 ? -13.74703 -0.05234  -25.58473 1.000 8.00704  ? 317 ALA   A C   1 
ATOM   1827 O  O   . ALA   A 1 317 ? -14.30038 0.30730   -24.54097 1.000 6.38202  ? 317 ALA   A O   1 
ATOM   1828 C  CB  . ALA   A 1 317 ? -11.40478 0.72304   -26.00843 1.000 6.53623  ? 317 ALA   A CB  1 
ATOM   1829 N  N   . ASP   A 1 318 ? -14.38758 -0.14238  -26.75147 1.000 9.46854  ? 318 ASP   A N   1 
ATOM   1830 C  CA  . ASP   A 1 318 ? -15.81130 0.14906   -26.84667 1.000 8.01084  ? 318 ASP   A CA  1 
ATOM   1831 C  C   . ASP   A 1 318 ? -16.61392 -0.85533  -26.04209 1.000 10.43798 ? 318 ASP   A C   1 
ATOM   1832 O  O   . ASP   A 1 318 ? -17.62952 -0.50105  -25.44191 1.000 8.22778  ? 318 ASP   A O   1 
ATOM   1833 C  CB  . ASP   A 1 318 ? -16.25741 0.12571   -28.30323 1.000 11.56772 ? 318 ASP   A CB  1 
ATOM   1834 C  CG  . ASP   A 1 318 ? -17.42674 1.07361   -28.58838 1.000 8.32315  ? 318 ASP   A CG  1 
ATOM   1835 O  OD1 . ASP   A 1 318 ? -17.81723 1.90357   -27.73419 1.000 5.06769  ? 318 ASP   A OD1 1 
ATOM   1836 O  OD2 . ASP   A 1 318 ? -17.93061 0.98660   -29.70994 1.000 7.83574  ? 318 ASP   A OD2 1 
ATOM   1837 N  N   . LEU   A 1 319 ? -16.16096 -2.11057  -26.01002 1.000 8.31456  ? 319 LEU   A N   1 
ATOM   1838 C  CA  . LEU   A 1 319 ? -16.83625 -3.19541  -25.30123 1.000 7.01232  ? 319 LEU   A CA  1 
ATOM   1839 C  C   . LEU   A 1 319 ? -16.14173 -3.52567  -23.99242 1.000 11.06543 ? 319 LEU   A C   1 
ATOM   1840 O  O   . LEU   A 1 319 ? -16.03498 -4.70362  -23.62961 1.000 12.05929 ? 319 LEU   A O   1 
ATOM   1841 C  CB  . LEU   A 1 319 ? -16.91512 -4.44644  -26.18249 1.000 10.03978 ? 319 LEU   A CB  1 
ATOM   1842 C  CG  . LEU   A 1 319 ? -17.87547 -4.28579  -27.36699 1.000 12.93362 ? 319 LEU   A CG  1 
ATOM   1843 C  CD1 . LEU   A 1 319 ? -17.87827 -5.48914  -28.30359 1.000 13.18075 ? 319 LEU   A CD1 1 
ATOM   1844 C  CD2 . LEU   A 1 319 ? -19.25825 -4.00805  -26.83669 1.000 18.83738 ? 319 LEU   A CD2 1 
ATOM   1845 N  N   . SER   A 1 320 ? -15.63636 -2.53269  -23.25822 1.000 8.61929  ? 320 SER   A N   1 
ATOM   1846 C  CA  . SER   A 1 320 ? -14.86322 -2.85960  -22.07116 1.000 10.33450 ? 320 SER   A CA  1 
ATOM   1847 C  C   . SER   A 1 320 ? -15.61361 -2.63062  -20.76981 1.000 8.74756  ? 320 SER   A C   1 
ATOM   1848 O  O   . SER   A 1 320 ? -15.05505 -2.92245  -19.70698 1.000 13.58302 ? 320 SER   A O   1 
ATOM   1849 C  CB  . SER   A 1 320 ? -13.53724 -2.08334  -22.04973 1.000 10.74712 ? 320 SER   A CB  1 
ATOM   1850 O  OG  . SER   A 1 320 ? -13.72751 -0.69689  -21.91878 1.000 8.05387  ? 320 SER   A OG  1 
ATOM   1851 N  N   . ASN   A 1 321 ? -16.84393 -2.12225  -20.81697 1.000 10.72596 ? 321 ASN   A N   1 
ATOM   1852 C  CA  . ASN   A 1 321 ? -17.59423 -1.86668  -19.58528 1.000 9.65116  ? 321 ASN   A CA  1 
ATOM   1853 C  C   . ASN   A 1 321 ? -17.63141 -3.08348  -18.66761 1.000 15.10259 ? 321 ASN   A C   1 
ATOM   1854 O  O   . ASN   A 1 321 ? -17.39309 -2.92098  -17.46332 1.000 16.62452 ? 321 ASN   A O   1 
ATOM   1855 C  CB  . ASN   A 1 321 ? -19.04221 -1.43253  -19.86713 1.000 6.33967  ? 321 ASN   A CB  1 
ATOM   1856 C  CG  . ASN   A 1 321 ? -19.16875 -0.10246  -20.56701 1.000 9.45243  ? 321 ASN   A CG  1 
ATOM   1857 O  OD1 . ASN   A 1 321 ? -20.24186 0.22142   -21.05935 1.000 10.59327 ? 321 ASN   A OD1 1 
ATOM   1858 N  ND2 . ASN   A 1 321 ? -18.10745 0.67055   -20.61761 1.000 10.45089 ? 321 ASN   A ND2 1 
ATOM   1859 N  N   . PRO   A 1 322 ? -17.91820 -4.30447  -19.14428 1.000 12.04337 ? 322 PRO   A N   1 
ATOM   1860 C  CA  . PRO   A 1 322 ? -17.96139 -5.44482  -18.22976 1.000 13.02191 ? 322 PRO   A CA  1 
ATOM   1861 C  C   . PRO   A 1 322 ? -16.58746 -5.93842  -17.79456 1.000 13.24309 ? 322 PRO   A C   1 
ATOM   1862 O  O   . PRO   A 1 322 ? -16.52275 -6.85679  -16.98284 1.000 10.80317 ? 322 PRO   A O   1 
ATOM   1863 C  CB  . PRO   A 1 322 ? -18.71576 -6.51275  -19.04184 1.000 12.05385 ? 322 PRO   A CB  1 
ATOM   1864 C  CG  . PRO   A 1 322 ? -19.41837 -5.75056  -20.14252 1.000 8.57434  ? 322 PRO   A CG  1 
ATOM   1865 C  CD  . PRO   A 1 322 ? -18.44489 -4.67679  -20.46858 1.000 11.71624 ? 322 PRO   A CD  1 
ATOM   1866 N  N   . THR   A 1 323 ? -15.48930 -5.35156  -18.26181 1.000 8.76639  ? 323 THR   A N   1 
ATOM   1867 C  CA  . THR   A 1 323 ? -14.17850 -5.68528  -17.71918 1.000 8.55780  ? 323 THR   A CA  1 
ATOM   1868 C  C   . THR   A 1 323 ? -13.74254 -4.72378  -16.63586 1.000 11.07104 ? 323 THR   A C   1 
ATOM   1869 O  O   . THR   A 1 323 ? -12.63570 -4.86254  -16.11881 1.000 12.47194 ? 323 THR   A O   1 
ATOM   1870 C  CB  . THR   A 1 323 ? -13.09663 -5.70662  -18.80900 1.000 11.91211 ? 323 THR   A CB  1 
ATOM   1871 O  OG1 . THR   A 1 323 ? -12.69452 -4.36205  -19.13175 1.000 12.88127 ? 323 THR   A OG1 1 
ATOM   1872 C  CG2 . THR   A 1 323 ? -13.58597 -6.43211  -20.05472 1.000 9.08253  ? 323 THR   A CG2 1 
ATOM   1873 N  N   . LYS   A 1 324 ? -14.56054 -3.75662  -16.30029 1.000 13.19018 ? 324 LYS   A N   1 
ATOM   1874 C  CA  . LYS   A 1 324 ? -14.15564 -2.72423  -15.36494 1.000 12.54714 ? 324 LYS   A CA  1 
ATOM   1875 C  C   . LYS   A 1 324 ? -14.57910 -3.10301  -13.95428 1.000 13.00605 ? 324 LYS   A C   1 
ATOM   1876 O  O   . LYS   A 1 324 ? -15.44700 -3.96241  -13.77022 1.000 10.84543 ? 324 LYS   A O   1 
ATOM   1877 C  CB  . LYS   A 1 324 ? -14.78137 -1.39281  -15.76338 1.000 9.99832  ? 324 LYS   A CB  1 
ATOM   1878 C  CG  . LYS   A 1 324 ? -14.27677 -0.85144  -17.09138 1.000 10.04788 ? 324 LYS   A CG  1 
ATOM   1879 C  CD  . LYS   A 1 324 ? -12.77353 -0.53539  -17.00129 1.000 10.53774 ? 324 LYS   A CD  1 
ATOM   1880 C  CE  . LYS   A 1 324 ? -12.22127 -0.07371  -18.32638 1.000 8.42523  ? 324 LYS   A CE  1 
ATOM   1881 N  NZ  . LYS   A 1 324 ? -12.77677 1.24459   -18.74721 1.000 7.58935  ? 324 LYS   A NZ  1 
ATOM   1882 N  N   . PRO   A 1 325 ? -13.96367 -2.48023  -12.92391 1.000 13.56209 ? 325 PRO   A N   1 
ATOM   1883 C  CA  . PRO   A 1 325 ? -14.47942 -2.62413  -11.55570 1.000 13.05201 ? 325 PRO   A CA  1 
ATOM   1884 C  C   . PRO   A 1 325 ? -15.99654 -2.53255  -11.50210 1.000 13.47321 ? 325 PRO   A C   1 
ATOM   1885 O  O   . PRO   A 1 325 ? -16.59590 -1.72577  -12.21630 1.000 15.02930 ? 325 PRO   A O   1 
ATOM   1886 C  CB  . PRO   A 1 325 ? -13.79953 -1.46756  -10.81436 1.000 14.24688 ? 325 PRO   A CB  1 
ATOM   1887 C  CG  . PRO   A 1 325 ? -12.44204 -1.39849  -11.47602 1.000 15.76914 ? 325 PRO   A CG  1 
ATOM   1888 C  CD  . PRO   A 1 325 ? -12.74754 -1.64229  -12.96253 1.000 15.84468 ? 325 PRO   A CD  1 
ATOM   1889 N  N   . LEU   A 1 326 ? -16.62669 -3.36568  -10.67408 1.000 13.82416 ? 326 LEU   A N   1 
ATOM   1890 C  CA  . LEU   A 1 326 ? -18.07344 -3.54563  -10.77613 1.000 14.54133 ? 326 LEU   A CA  1 
ATOM   1891 C  C   . LEU   A 1 326 ? -18.83403 -2.25277  -10.53030 1.000 16.78710 ? 326 LEU   A C   1 
ATOM   1892 O  O   . LEU   A 1 326 ? -19.94470 -2.08015  -11.04947 1.000 15.82162 ? 326 LEU   A O   1 
ATOM   1893 C  CB  . LEU   A 1 326 ? -18.54097 -4.60709  -9.78799  1.000 13.95139 ? 326 LEU   A CB  1 
ATOM   1894 C  CG  . LEU   A 1 326 ? -20.03154 -4.91992  -9.78984  1.000 18.11841 ? 326 LEU   A CG  1 
ATOM   1895 C  CD1 . LEU   A 1 326 ? -20.41331 -5.59161  -11.11519 1.000 13.33548 ? 326 LEU   A CD1 1 
ATOM   1896 C  CD2 . LEU   A 1 326 ? -20.38746 -5.79781  -8.61097  1.000 16.97179 ? 326 LEU   A CD2 1 
ATOM   1897 N  N   . GLN   A 1 327 ? -18.27873 -1.34125  -9.72269  1.000 15.04858 ? 327 GLN   A N   1 
ATOM   1898 C  CA  . GLN   A 1 327 ? -19.00298 -0.10218  -9.48715  1.000 17.49379 ? 327 GLN   A CA  1 
ATOM   1899 C  C   . GLN   A 1 327 ? -19.10337 0.72041   -10.77436 1.000 18.20063 ? 327 GLN   A C   1 
ATOM   1900 O  O   . GLN   A 1 327 ? -20.12054 1.38146   -11.00788 1.000 19.18463 ? 327 GLN   A O   1 
ATOM   1901 C  CB  . GLN   A 1 327 ? -18.35177 0.67092   -8.33268  1.000 14.63109 ? 327 GLN   A CB  1 
ATOM   1902 C  CG  . GLN   A 1 327 ? -17.13046 1.48778   -8.64763  1.000 8.52789  ? 327 GLN   A CG  1 
ATOM   1903 C  CD  . GLN   A 1 327 ? -15.87673 0.66160   -8.84140  1.000 21.53184 ? 327 GLN   A CD  1 
ATOM   1904 O  OE1 . GLN   A 1 327 ? -15.83902 -0.53571  -8.54685  1.000 20.88709 ? 327 GLN   A OE1 1 
ATOM   1905 N  NE2 . GLN   A 1 327 ? -14.83498 1.30027   -9.36165  1.000 23.15619 ? 327 GLN   A NE2 1 
ATOM   1906 N  N   . LEU   A 1 328 ? -18.08956 0.63869   -11.64153 1.000 16.34829 ? 328 LEU   A N   1 
ATOM   1907 C  CA  . LEU   A 1 328 ? -18.12697 1.28210   -12.95707 1.000 17.82663 ? 328 LEU   A CA  1 
ATOM   1908 C  C   . LEU   A 1 328 ? -19.02389 0.50481   -13.91106 1.000 14.48845 ? 328 LEU   A C   1 
ATOM   1909 O  O   . LEU   A 1 328 ? -19.93194 1.07366   -14.53886 1.000 10.92885 ? 328 LEU   A O   1 
ATOM   1910 C  CB  . LEU   A 1 328 ? -16.69796 1.39175   -13.53177 1.000 11.41264 ? 328 LEU   A CB  1 
ATOM   1911 C  CG  . LEU   A 1 328 ? -15.71089 2.21795   -12.69860 1.000 18.42221 ? 328 LEU   A CG  1 
ATOM   1912 C  CD1 . LEU   A 1 328 ? -14.31644 2.41991   -13.36255 1.000 14.38919 ? 328 LEU   A CD1 1 
ATOM   1913 C  CD2 . LEU   A 1 328 ? -16.31568 3.57253   -12.30274 1.000 14.23123 ? 328 LEU   A CD2 1 
ATOM   1914 N  N   . TYR   A 1 329 ? -18.78440 -0.81006  -14.00757 1.000 13.65959 ? 329 TYR   A N   1 
ATOM   1915 C  CA  . TYR   A 1 329 ? -19.60101 -1.67999  -14.84559 1.000 12.52774 ? 329 TYR   A CA  1 
ATOM   1916 C  C   . TYR   A 1 329 ? -21.08724 -1.45462  -14.58787 1.000 12.30439 ? 329 TYR   A C   1 
ATOM   1917 O  O   . TYR   A 1 329 ? -21.86673 -1.24992  -15.52486 1.000 12.06086 ? 329 TYR   A O   1 
ATOM   1918 C  CB  . TYR   A 1 329 ? -19.19849 -3.15076  -14.60992 1.000 10.56931 ? 329 TYR   A CB  1 
ATOM   1919 C  CG  . TYR   A 1 329 ? -19.94363 -4.17799  -15.46036 1.000 10.85315 ? 329 TYR   A CG  1 
ATOM   1920 C  CD1 . TYR   A 1 329 ? -20.66447 -3.79344  -16.59313 1.000 9.33339  ? 329 TYR   A CD1 1 
ATOM   1921 C  CD2 . TYR   A 1 329 ? -19.92706 -5.53161  -15.12156 1.000 11.28263 ? 329 TYR   A CD2 1 
ATOM   1922 C  CE1 . TYR   A 1 329 ? -21.36282 -4.72378  -17.35016 1.000 11.39743 ? 329 TYR   A CE1 1 
ATOM   1923 C  CE2 . TYR   A 1 329 ? -20.61563 -6.47389  -15.86867 1.000 11.47383 ? 329 TYR   A CE2 1 
ATOM   1924 C  CZ  . TYR   A 1 329 ? -21.33390 -6.06406  -16.97817 1.000 14.86833 ? 329 TYR   A CZ  1 
ATOM   1925 O  OH  . TYR   A 1 329 ? -22.01309 -6.98521  -17.72969 1.000 14.58145 ? 329 TYR   A OH  1 
ATOM   1926 N  N   . ARG   A 1 330 ? -21.49957 -1.46630  -13.31808 1.000 12.69187 ? 330 ARG   A N   1 
ATOM   1927 C  CA  . ARG   A 1 330 ? -22.92851 -1.38707  -13.02739 1.000 12.47476 ? 330 ARG   A CA  1 
ATOM   1928 C  C   . ARG   A 1 330 ? -23.52613 -0.09501  -13.55523 1.000 11.64558 ? 330 ARG   A C   1 
ATOM   1929 O  O   . ARG   A 1 330 ? -24.62754 -0.08672  -14.11180 1.000 11.98173 ? 330 ARG   A O   1 
ATOM   1930 C  CB  . ARG   A 1 330 ? -23.17312 -1.50728  -11.52421 1.000 13.90976 ? 330 ARG   A CB  1 
ATOM   1931 C  CG  . ARG   A 1 330 ? -23.31237 -2.95523  -11.06229 1.000 18.52578 ? 330 ARG   A CG  1 
ATOM   1932 C  CD  . ARG   A 1 330 ? -24.42331 -3.05240  -10.03583 1.000 18.18267 ? 330 ARG   A CD  1 
ATOM   1933 N  NE  . ARG   A 1 330 ? -23.87616 -3.17629  -8.70572  1.000 37.99797 ? 330 ARG   A NE  1 
ATOM   1934 C  CZ  . ARG   A 1 330 ? -24.61313 -3.19205  -7.60753  1.000 27.12330 ? 330 ARG   A CZ  1 
ATOM   1935 N  NH1 . ARG   A 1 330 ? -25.93125 -3.06792  -7.69223  1.000 27.26516 ? 330 ARG   A NH1 1 
ATOM   1936 N  NH2 . ARG   A 1 330 ? -24.02401 -3.32088  -6.43656  1.000 36.11468 ? 330 ARG   A NH2 1 
ATOM   1937 N  N   . GLN   A 1 331 ? -22.80655 1.00661   -13.38590 1.000 10.49122 ? 331 GLN   A N   1 
ATOM   1938 C  CA  . GLN   A 1 331 ? -23.30676 2.30053   -13.81423 1.000 14.39800 ? 331 GLN   A CA  1 
ATOM   1939 C  C   . GLN   A 1 331 ? -23.35935 2.39384   -15.34324 1.000 14.40713 ? 331 GLN   A C   1 
ATOM   1940 O  O   . GLN   A 1 331 ? -24.25159 3.04166   -15.89949 1.000 11.71624 ? 331 GLN   A O   1 
ATOM   1941 C  CB  . GLN   A 1 331 ? -22.42065 3.38185   -13.17077 1.000 13.97397 ? 331 GLN   A CB  1 
ATOM   1942 C  CG  . GLN   A 1 331 ? -22.78523 4.79220   -13.50102 1.000 25.92749 ? 331 GLN   A CG  1 
ATOM   1943 C  CD  . GLN   A 1 331 ? -24.12850 5.23451   -12.95438 1.000 37.71897 ? 331 GLN   A CD  1 
ATOM   1944 O  OE1 . GLN   A 1 331 ? -24.56126 6.36546   -13.21174 1.000 47.88886 ? 331 GLN   A OE1 1 
ATOM   1945 N  NE2 . GLN   A 1 331 ? -24.80033 4.34950   -12.19305 1.000 27.99821 ? 331 GLN   A NE2 1 
ATOM   1946 N  N   . TRP   A 1 332 ? -22.44222 1.71841   -16.04041 1.000 10.51796 ? 332 TRP   A N   1 
ATOM   1947 C  CA  . TRP   A 1 332 ? -22.54040 1.64212   -17.49074 1.000 8.35112  ? 332 TRP   A CA  1 
ATOM   1948 C  C   . TRP   A 1 332 ? -23.76132 0.83764   -17.91497 1.000 13.19169 ? 332 TRP   A C   1 
ATOM   1949 O  O   . TRP   A 1 332 ? -24.39217 1.14294   -18.93832 1.000 9.52673  ? 332 TRP   A O   1 
ATOM   1950 C  CB  . TRP   A 1 332 ? -21.26349 1.03164   -18.07055 1.000 9.53134  ? 332 TRP   A CB  1 
ATOM   1951 C  CG  . TRP   A 1 332 ? -20.06453 1.94426   -18.02930 1.000 7.15224  ? 332 TRP   A CG  1 
ATOM   1952 C  CD1 . TRP   A 1 332 ? -18.86267 1.68840   -17.44151 1.000 7.50382  ? 332 TRP   A CD1 1 
ATOM   1953 C  CD2 . TRP   A 1 332 ? -19.94412 3.24079   -18.64477 1.000 7.87247  ? 332 TRP   A CD2 1 
ATOM   1954 N  NE1 . TRP   A 1 332 ? -18.00391 2.74566   -17.63746 1.000 9.26290  ? 332 TRP   A NE1 1 
ATOM   1955 C  CE2 . TRP   A 1 332 ? -18.64491 3.71439   -18.36762 1.000 8.79637  ? 332 TRP   A CE2 1 
ATOM   1956 C  CE3 . TRP   A 1 332 ? -20.80834 4.04300   -19.40089 1.000 9.88094  ? 332 TRP   A CE3 1 
ATOM   1957 C  CZ2 . TRP   A 1 332 ? -18.18690 4.94980   -18.82217 1.000 9.14958  ? 332 TRP   A CZ2 1 
ATOM   1958 C  CZ3 . TRP   A 1 332 ? -20.35330 5.28001   -19.84149 1.000 11.30232 ? 332 TRP   A CZ3 1 
ATOM   1959 C  CH2 . TRP   A 1 332 ? -19.05857 5.71729   -19.55390 1.000 10.67044 ? 332 TRP   A CH2 1 
ATOM   1960 N  N   . THR   A 1 333 ? -24.13481 -0.16782  -17.12273 1.000 11.64277 ? 333 THR   A N   1 
ATOM   1961 C  CA  . THR   A 1 333 ? -25.30694 -0.95833  -17.47054 1.000 11.48197 ? 333 THR   A CA  1 
ATOM   1962 C  C   . THR   A 1 333 ? -26.57809 -0.16231  -17.22822 1.000 13.60026 ? 333 THR   A C   1 
ATOM   1963 O  O   . THR   A 1 333 ? -27.50675 -0.18941  -18.04952 1.000 10.68015 ? 333 THR   A O   1 
ATOM   1964 C  CB  . THR   A 1 333 ? -25.30636 -2.26221  -16.66757 1.000 11.72389 ? 333 THR   A CB  1 
ATOM   1965 O  OG1 . THR   A 1 333 ? -24.13513 -3.01859  -16.99963 1.000 13.08629 ? 333 THR   A OG1 1 
ATOM   1966 C  CG2 . THR   A 1 333 ? -26.54446 -3.09255  -16.96651 1.000 12.98613 ? 333 THR   A CG2 1 
ATOM   1967 N  N   . ASP   A 1 334 ? -26.63513 0.55362   -16.09963 1.000 14.32067 ? 334 ASP   A N   1 
ATOM   1968 C  CA  . ASP   A 1 334 ? -27.77759 1.41635   -15.84196 1.000 10.30403 ? 334 ASP   A CA  1 
ATOM   1969 C  C   . ASP   A 1 334 ? -27.97956 2.36340   -16.99956 1.000 11.53649 ? 334 ASP   A C   1 
ATOM   1970 O  O   . ASP   A 1 334 ? -29.10987 2.58251   -17.44730 1.000 15.23357 ? 334 ASP   A O   1 
ATOM   1971 C  CB  . ASP   A 1 334 ? -27.57519 2.20004   -14.54385 1.000 13.71211 ? 334 ASP   A CB  1 
ATOM   1972 C  CG  . ASP   A 1 334 ? -27.50287 1.31025   -13.33160 1.000 16.26771 ? 334 ASP   A CG  1 
ATOM   1973 O  OD1 . ASP   A 1 334 ? -27.94877 0.14024   -13.40495 1.000 18.42175 ? 334 ASP   A OD1 1 
ATOM   1974 O  OD2 . ASP   A 1 334 ? -26.98728 1.78429   -12.29875 1.000 19.30675 ? 334 ASP   A OD2 1 
ATOM   1975 N  N   . ARG   A 1 335 ? -26.87840 2.87596   -17.54490 1.000 11.78630 ? 335 ARG   A N   1 
ATOM   1976 C  CA  . ARG   A 1 335 ? -26.97093 3.83865   -18.63299 1.000 12.54982 ? 335 ARG   A CA  1 
ATOM   1977 C  C   . ARG   A 1 335 ? -27.39238 3.18402   -19.93906 1.000 11.71226 ? 335 ARG   A C   1 
ATOM   1978 O  O   . ARG   A 1 335 ? -28.23119 3.73317   -20.66003 1.000 12.96912 ? 335 ARG   A O   1 
ATOM   1979 C  CB  . ARG   A 1 335 ? -25.63962 4.57500   -18.78492 1.000 12.30717 ? 335 ARG   A CB  1 
ATOM   1980 C  CG  . ARG   A 1 335 ? -25.46410 5.60488   -17.67147 1.000 14.69472 ? 335 ARG   A CG  1 
ATOM   1981 C  CD  . ARG   A 1 335 ? -24.08734 6.20595   -17.64873 1.000 13.91928 ? 335 ARG   A CD  1 
ATOM   1982 N  NE  . ARG   A 1 335 ? -23.93438 7.23071   -16.60743 1.000 15.90768 ? 335 ARG   A NE  1 
ATOM   1983 C  CZ  . ARG   A 1 335 ? -24.12923 8.53650   -16.80668 1.000 14.62313 ? 335 ARG   A CZ  1 
ATOM   1984 N  NH1 . ARG   A 1 335 ? -24.49214 8.98855   -18.00349 1.000 9.38521  ? 335 ARG   A NH1 1 
ATOM   1985 N  NH2 . ARG   A 1 335 ? -23.96623 9.39085   -15.80774 1.000 16.60520 ? 335 ARG   A NH2 1 
ATOM   1986 N  N   . ILE   A 1 336 ? -26.83058 2.02152   -20.28071 1.000 12.66744 ? 336 ILE   A N   1 
ATOM   1987 C  CA  . ILE   A 1 336 ? -27.25333 1.43338   -21.54935 1.000 11.95235 ? 336 ILE   A CA  1 
ATOM   1988 C  C   . ILE   A 1 336 ? -28.69371 0.96178   -21.45126 1.000 14.38464 ? 336 ILE   A C   1 
ATOM   1989 O  O   . ILE   A 1 336 ? -29.46525 1.07633   -22.42109 1.000 13.63344 ? 336 ILE   A O   1 
ATOM   1990 C  CB  . ILE   A 1 336 ? -26.31539 0.29935   -22.01437 1.000 13.52488 ? 336 ILE   A CB  1 
ATOM   1991 C  CG1 . ILE   A 1 336 ? -26.51149 0.06619   -23.51356 1.000 13.99702 ? 336 ILE   A CG1 1 
ATOM   1992 C  CG2 . ILE   A 1 336 ? -26.58194 -1.01493  -21.28681 1.000 11.27939 ? 336 ILE   A CG2 1 
ATOM   1993 C  CD1 . ILE   A 1 336 ? -26.31227 1.28512   -24.33080 1.000 12.31305 ? 336 ILE   A CD1 1 
ATOM   1994 N  N   . MET   A 1 337 ? -29.10390 0.47591   -20.27877 1.000 12.62078 ? 337 MET   A N   1 
ATOM   1995 C  CA  . MET   A 1 337 ? -30.48490 0.03211   -20.13971 1.000 12.36118 ? 337 MET   A CA  1 
ATOM   1996 C  C   . MET   A 1 337 ? -31.45247 1.19489   -20.30887 1.000 14.07899 ? 337 MET   A C   1 
ATOM   1997 O  O   . MET   A 1 337 ? -32.45036 1.08235   -21.02546 1.000 17.57124 ? 337 MET   A O   1 
ATOM   1998 C  CB  . MET   A 1 337 ? -30.68291 -0.67693  -18.79744 1.000 14.53165 ? 337 MET   A CB  1 
ATOM   1999 C  CG  . MET   A 1 337 ? -30.01006 -2.06450  -18.73235 1.000 12.79363 ? 337 MET   A CG  1 
ATOM   2000 S  SD  . MET   A 1 337 ? -30.33857 -3.12522  -20.17764 1.000 27.43670 ? 337 MET   A SD  1 
ATOM   2001 C  CE  . MET   A 1 337 ? -32.12466 -3.05892  -20.27129 1.000 22.79927 ? 337 MET   A CE  1 
ATOM   2002 N  N   . GLU   A 1 338 ? -31.13969 2.34767   -19.72684 1.000 15.73593 ? 338 GLU   A N   1 
ATOM   2003 C  CA  . GLU   A 1 338 ? -32.03722 3.48123   -19.88827 1.000 15.98577 ? 338 GLU   A CA  1 
ATOM   2004 C  C   . GLU   A 1 338 ? -32.12456 3.93085   -21.35441 1.000 19.46402 ? 338 GLU   A C   1 
ATOM   2005 O  O   . GLU   A 1 338 ? -33.21064 4.24862   -21.84693 1.000 22.19759 ? 338 GLU   A O   1 
ATOM   2006 C  CB  . GLU   A 1 338 ? -31.58533 4.61561   -18.98301 1.000 15.41461 ? 338 GLU   A CB  1 
ATOM   2007 C  CG  . GLU   A 1 338 ? -32.70334 5.51932   -18.58599 1.000 28.12861 ? 338 GLU   A CG  1 
ATOM   2008 C  CD  . GLU   A 1 338 ? -32.21864 6.90259   -18.31459 1.000 39.15365 ? 338 GLU   A CD  1 
ATOM   2009 O  OE1 . GLU   A 1 338 ? -31.53889 7.11771   -17.28157 1.000 46.97800 ? 338 GLU   A OE1 1 
ATOM   2010 O  OE2 . GLU   A 1 338 ? -32.48597 7.76742   -19.16994 1.000 44.66281 ? 338 GLU   A OE2 1 
ATOM   2011 N  N   . GLU   A 1 339 ? -30.99813 3.94271   -22.07653 1.000 16.55820 ? 339 GLU   A N   1 
ATOM   2012 C  CA  . GLU   A 1 339 ? -31.02525 4.30937   -23.49294 1.000 15.37028 ? 339 GLU   A CA  1 
ATOM   2013 C  C   . GLU   A 1 339 ? -31.86511 3.32861   -24.32309 1.000 16.02304 ? 339 GLU   A C   1 
ATOM   2014 O  O   . GLU   A 1 339 ? -32.69198 3.74418   -25.14046 1.000 18.84740 ? 339 GLU   A O   1 
ATOM   2015 C  CB  . GLU   A 1 339 ? -29.59410 4.39637   -24.02817 1.000 18.33466 ? 339 GLU   A CB  1 
ATOM   2016 C  CG  . GLU   A 1 339 ? -29.44012 5.21764   -25.33249 1.000 16.27417 ? 339 GLU   A CG  1 
ATOM   2017 C  CD  . GLU   A 1 339 ? -27.97384 5.43667   -25.71745 1.000 15.20129 ? 339 GLU   A CD  1 
ATOM   2018 O  OE1 . GLU   A 1 339 ? -27.23977 6.07088   -24.93791 1.000 16.44354 ? 339 GLU   A OE1 1 
ATOM   2019 O  OE2 . GLU   A 1 339 ? -27.55257 4.96049   -26.79378 1.000 16.41633 ? 339 GLU   A OE2 1 
ATOM   2020 N  N   . PHE   A 1 340 ? -31.65814 2.01900   -24.13708 1.000 16.68019 ? 340 PHE   A N   1 
ATOM   2021 C  CA  . PHE   A 1 340 ? -32.45890 1.02625   -24.85437 1.000 16.37155 ? 340 PHE   A CA  1 
ATOM   2022 C  C   . PHE   A 1 340 ? -33.94070 1.16474   -24.51892 1.000 25.40266 ? 340 PHE   A C   1 
ATOM   2023 O  O   . PHE   A 1 340 ? -34.80371 1.07643   -25.40804 1.000 23.61569 ? 340 PHE   A O   1 
ATOM   2024 C  CB  . PHE   A 1 340 ? -31.97997 -0.39020  -24.51294 1.000 17.24790 ? 340 PHE   A CB  1 
ATOM   2025 C  CG  . PHE   A 1 340 ? -30.66951 -0.77785  -25.16641 1.000 26.63456 ? 340 PHE   A CG  1 
ATOM   2026 C  CD1 . PHE   A 1 340 ? -30.02500 0.07565   -26.05256 1.000 17.19679 ? 340 PHE   A CD1 1 
ATOM   2027 C  CD2 . PHE   A 1 340 ? -30.09106 -2.01128  -24.89899 1.000 27.79608 ? 340 PHE   A CD2 1 
ATOM   2028 C  CE1 . PHE   A 1 340 ? -28.83380 -0.30140  -26.64832 1.000 24.38103 ? 340 PHE   A CE1 1 
ATOM   2029 C  CE2 . PHE   A 1 340 ? -28.90562 -2.38833  -25.49776 1.000 23.51030 ? 340 PHE   A CE2 1 
ATOM   2030 C  CZ  . PHE   A 1 340 ? -28.27675 -1.53437  -26.37466 1.000 20.07001 ? 340 PHE   A CZ  1 
ATOM   2031 N  N   . PHE   A 1 341 ? -34.24900 1.36467   -23.22972 1.000 22.28450 ? 341 PHE   A N   1 
ATOM   2032 C  CA  . PHE   A 1 341 ? -35.62632 1.56965   -22.79933 1.000 23.55450 ? 341 PHE   A CA  1 
ATOM   2033 C  C   . PHE   A 1 341 ? -36.25317 2.78087   -23.47527 1.000 23.80913 ? 341 PHE   A C   1 
ATOM   2034 O  O   . PHE   A 1 341 ? -37.41543 2.73070   -23.88878 1.000 27.48765 ? 341 PHE   A O   1 
ATOM   2035 C  CB  . PHE   A 1 341 ? -35.67958 1.71846   -21.27837 1.000 19.23112 ? 341 PHE   A CB  1 
ATOM   2036 C  CG  . PHE   A 1 341 ? -35.49971 0.42591   -20.54133 1.000 19.80410 ? 341 PHE   A CG  1 
ATOM   2037 C  CD1 . PHE   A 1 341 ? -35.60136 -0.78285  -21.20043 1.000 22.42443 ? 341 PHE   A CD1 1 
ATOM   2038 C  CD2 . PHE   A 1 341 ? -35.24829 0.41878   -19.17842 1.000 23.08556 ? 341 PHE   A CD2 1 
ATOM   2039 C  CE1 . PHE   A 1 341 ? -35.43783 -1.97144  -20.51764 1.000 25.85223 ? 341 PHE   A CE1 1 
ATOM   2040 C  CE2 . PHE   A 1 341 ? -35.08873 -0.77237  -18.49096 1.000 19.27972 ? 341 PHE   A CE2 1 
ATOM   2041 C  CZ  . PHE   A 1 341 ? -35.18045 -1.96184  -19.15967 1.000 20.38898 ? 341 PHE   A CZ  1 
ATOM   2042 N  N   . ARG   A 1 342 ? -35.51338 3.88672   -23.57960 1.000 25.68757 ? 342 ARG   A N   1 
ATOM   2043 C  CA  . ARG   A 1 342 ? -36.06213 5.05567   -24.26185 1.000 28.35771 ? 342 ARG   A CA  1 
ATOM   2044 C  C   . ARG   A 1 342 ? -36.30425 4.75996   -25.73595 1.000 29.32686 ? 342 ARG   A C   1 
ATOM   2045 O  O   . ARG   A 1 342 ? -37.30140 5.21074   -26.31446 1.000 34.24964 ? 342 ARG   A O   1 
ATOM   2046 C  CB  . ARG   A 1 342 ? -35.13490 6.26638   -24.09756 1.000 25.80279 ? 342 ARG   A CB  1 
ATOM   2047 C  CG  . ARG   A 1 342 ? -35.19885 6.90491   -22.72221 1.000 29.39865 ? 342 ARG   A CG  1 
ATOM   2048 C  CD  . ARG   A 1 342 ? -34.60998 8.30090   -22.72458 1.000 45.67479 ? 342 ARG   A CD  1 
ATOM   2049 N  NE  . ARG   A 1 342 ? -33.54736 8.44398   -21.72825 1.000 45.94378 ? 342 ARG   A NE  1 
ATOM   2050 C  CZ  . ARG   A 1 342 ? -32.81255 9.54135   -21.57132 1.000 44.90452 ? 342 ARG   A CZ  1 
ATOM   2051 N  NH1 . ARG   A 1 342 ? -33.02711 10.59775  -22.34278 1.000 49.60436 ? 342 ARG   A NH1 1 
ATOM   2052 N  NH2 . ARG   A 1 342 ? -31.86866 9.58682   -20.63822 1.000 44.73849 ? 342 ARG   A NH2 1 
ATOM   2053 N  N   . GLN   A 1 343 ? -35.40937 3.99394   -26.35946 1.000 27.83538 ? 343 GLN   A N   1 
ATOM   2054 C  CA  . GLN   A 1 343 ? -35.60881 3.62064   -27.75689 1.000 28.79700 ? 343 GLN   A CA  1 
ATOM   2055 C  C   . GLN   A 1 343 ? -36.88346 2.80455   -27.91468 1.000 30.74298 ? 343 GLN   A C   1 
ATOM   2056 O  O   . GLN   A 1 343 ? -37.69449 3.06497   -28.81039 1.000 27.35992 ? 343 GLN   A O   1 
ATOM   2057 C  CB  . GLN   A 1 343 ? -34.40338 2.83420   -28.27461 1.000 13.85006 ? 343 GLN   A CB  1 
ATOM   2058 C  CG  . GLN   A 1 343 ? -34.58867 2.23279   -29.67781 1.000 20.22995 ? 343 GLN   A CG  1 
ATOM   2059 C  CD  . GLN   A 1 343 ? -33.33299 1.52552   -30.19707 1.000 21.08317 ? 343 GLN   A CD  1 
ATOM   2060 O  OE1 . GLN   A 1 343 ? -32.22098 2.04728   -30.09686 1.000 17.95057 ? 343 GLN   A OE1 1 
ATOM   2061 N  NE2 . GLN   A 1 343 ? -33.50911 0.33016   -30.73533 1.000 20.90347 ? 343 GLN   A NE2 1 
ATOM   2062 N  N   . GLY   A 1 344 ? -37.06269 1.79907   -27.05377 1.000 23.15005 ? 344 GLY   A N   1 
ATOM   2063 C  CA  . GLY   A 1 344 ? -38.27775 1.00326   -27.09125 1.000 33.38175 ? 344 GLY   A CA  1 
ATOM   2064 C  C   . GLY   A 1 344 ? -39.53439 1.84074   -26.96082 1.000 31.57552 ? 344 GLY   A C   1 
ATOM   2065 O  O   . GLY   A 1 344 ? -40.51304 1.61105   -27.66760 1.000 34.04403 ? 344 GLY   A O   1 
ATOM   2066 N  N   . ASP   A 1 345 ? -39.51980 2.82943   -26.06447 1.000 29.79950 ? 345 ASP   A N   1 
ATOM   2067 C  CA  . ASP   A 1 345 ? -40.64992 3.74540   -25.94993 1.000 31.55863 ? 345 ASP   A CA  1 
ATOM   2068 C  C   . ASP   A 1 345 ? -40.92159 4.44667   -27.27626 1.000 37.83034 ? 345 ASP   A C   1 
ATOM   2069 O  O   . ASP   A 1 345 ? -42.07173 4.53401   -27.72108 1.000 43.75135 ? 345 ASP   A O   1 
ATOM   2070 C  CB  . ASP   A 1 345 ? -40.38482 4.76422   -24.84054 1.000 30.49355 ? 345 ASP   A CB  1 
ATOM   2071 C  CG  . ASP   A 1 345 ? -40.38129 4.13609   -23.45278 1.000 28.70541 ? 345 ASP   A CG  1 
ATOM   2072 O  OD1 . ASP   A 1 345 ? -40.47173 2.89902   -23.35668 1.000 33.22582 ? 345 ASP   A OD1 1 
ATOM   2073 O  OD2 . ASP   A 1 345 ? -40.26635 4.88072   -22.45506 1.000 28.33264 ? 345 ASP   A OD2 1 
ATOM   2074 N  N   . ARG   A 1 346 ? -39.87194 4.95538   -27.92887 1.000 32.78498 ? 346 ARG   A N   1 
ATOM   2075 C  CA  . ARG   A 1 346 ? -40.04739 5.50268   -29.27047 1.000 32.00774 ? 346 ARG   A CA  1 
ATOM   2076 C  C   . ARG   A 1 346 ? -40.58411 4.44638   -30.22410 1.000 34.71911 ? 346 ARG   A C   1 
ATOM   2077 O  O   . ARG   A 1 346 ? -41.42889 4.74167   -31.08178 1.000 40.89219 ? 346 ARG   A O   1 
ATOM   2078 C  CB  . ARG   A 1 346 ? -38.72918 6.07213   -29.79397 1.000 30.78537 ? 346 ARG   A CB  1 
ATOM   2079 C  CG  . ARG   A 1 346 ? -38.15863 7.17095   -28.93789 1.000 26.43796 ? 346 ARG   A CG  1 
ATOM   2080 C  CD  . ARG   A 1 346 ? -37.66494 8.29341   -29.81221 1.000 34.79648 ? 346 ARG   A CD  1 
ATOM   2081 N  NE  . ARG   A 1 346 ? -36.21224 8.35629   -29.90819 1.000 34.01097 ? 346 ARG   A NE  1 
ATOM   2082 C  CZ  . ARG   A 1 346 ? -35.55311 8.96665   -30.89150 1.000 40.61423 ? 346 ARG   A CZ  1 
ATOM   2083 N  NH1 . ARG   A 1 346 ? -36.21339 9.55753   -31.88941 1.000 32.49765 ? 346 ARG   A NH1 1 
ATOM   2084 N  NH2 . ARG   A 1 346 ? -34.22674 8.98184   -30.88035 1.000 36.85297 ? 346 ARG   A NH2 1 
ATOM   2085 N  N   . GLU   A 1 347 ? -40.09831 3.20820   -30.09681 1.000 29.74173 ? 347 GLU   A N   1 
ATOM   2086 C  CA  . GLU   A 1 347 ? -40.68382 2.11018   -30.85550 1.000 39.28561 ? 347 GLU   A CA  1 
ATOM   2087 C  C   . GLU   A 1 347 ? -42.15676 1.88731   -30.48343 1.000 43.79584 ? 347 GLU   A C   1 
ATOM   2088 O  O   . GLU   A 1 347 ? -42.94571 1.44820   -31.32993 1.000 43.42601 ? 347 GLU   A O   1 
ATOM   2089 C  CB  . GLU   A 1 347 ? -39.85067 0.84117   -30.65046 1.000 29.58245 ? 347 GLU   A CB  1 
ATOM   2090 C  CG  . GLU   A 1 347 ? -38.41935 0.95931   -31.17774 1.000 27.06838 ? 347 GLU   A CG  1 
ATOM   2091 C  CD  . GLU   A 1 347 ? -37.57776 -0.28509  -30.91348 1.000 38.04332 ? 347 GLU   A CD  1 
ATOM   2092 O  OE1 . GLU   A 1 347 ? -37.79738 -0.94343  -29.86940 1.000 34.20816 ? 347 GLU   A OE1 1 
ATOM   2093 O  OE2 . GLU   A 1 347 ? -36.69591 -0.60990  -31.74646 1.000 27.97178 ? 347 GLU   A OE2 1 
ATOM   2094 N  N   . ARG   A 1 348 ? -42.55273 2.20931   -29.24169 1.000 39.17252 ? 348 ARG   A N   1 
ATOM   2095 C  CA  . ARG   A 1 348 ? -43.95605 2.08074   -28.83629 1.000 45.64555 ? 348 ARG   A CA  1 
ATOM   2096 C  C   . ARG   A 1 348 ? -44.82343 3.12617   -29.52221 1.000 42.66621 ? 348 ARG   A C   1 
ATOM   2097 O  O   . ARG   A 1 348 ? -45.78372 2.79067   -30.22639 1.000 44.23566 ? 348 ARG   A O   1 
ATOM   2098 C  CB  . ARG   A 1 348 ? -44.09672 2.18817   -27.31028 1.000 46.07368 ? 348 ARG   A CB  1 
ATOM   2099 C  CG  . ARG   A 1 348 ? -44.93228 1.06968   -26.68670 1.000 42.00541 ? 348 ARG   A CG  1 
ATOM   2100 C  CD  . ARG   A 1 348 ? -45.01257 1.20271   -25.16996 1.000 51.55976 ? 348 ARG   A CD  1 
ATOM   2101 N  NE  . ARG   A 1 348 ? -43.72307 1.04950   -24.49691 1.000 47.76532 ? 348 ARG   A NE  1 
ATOM   2102 C  CZ  . ARG   A 1 348 ? -43.33281 -0.05723  -23.86803 1.000 50.67668 ? 348 ARG   A CZ  1 
ATOM   2103 N  NH1 . ARG   A 1 348 ? -44.12802 -1.12454  -23.83575 1.000 47.14695 ? 348 ARG   A NH1 1 
ATOM   2104 N  NH2 . ARG   A 1 348 ? -42.14465 -0.10012  -23.27290 1.000 38.90701 ? 348 ARG   A NH2 1 
ATOM   2105 N  N   . GLU   A 1 349 ? -44.48492 4.40305   -29.34289 1.000 35.50689 ? 349 GLU   A N   1 
ATOM   2106 C  CA  . GLU   A 1 349 ? -45.23274 5.49880   -29.95045 1.000 46.57723 ? 349 GLU   A CA  1 
ATOM   2107 C  C   . GLU   A 1 349 ? -45.17092 5.48769   -31.47745 1.000 45.00383 ? 349 GLU   A C   1 
ATOM   2108 O  O   . GLU   A 1 349 ? -45.59153 6.44893   -32.13031 1.000 55.19596 ? 349 GLU   A O   1 
ATOM   2109 C  CB  . GLU   A 1 349 ? -44.73594 6.84446   -29.40155 1.000 37.94726 ? 349 GLU   A CB  1 
ATOM   2110 C  CG  . GLU   A 1 349 ? -45.49370 7.29818   -28.15823 1.000 46.54205 ? 349 GLU   A CG  1 
ATOM   2111 C  CD  . GLU   A 1 349 ? -45.77301 8.79124   -28.15341 1.000 68.49534 ? 349 GLU   A CD  1 
ATOM   2112 O  OE1 . GLU   A 1 349 ? -44.80356 9.57872   -28.27942 1.000 60.57239 ? 349 GLU   A OE1 1 
ATOM   2113 O  OE2 . GLU   A 1 349 ? -46.96831 9.17174   -28.03895 1.000 71.02142 ? 349 GLU   A OE2 1 
ATOM   2114 N  N   . ARG   A 1 350 ? -44.67263 4.40152   -32.05900 1.000 50.32262 ? 350 ARG   A N   1 
ATOM   2115 C  CA  . ARG   A 1 350 ? -44.65589 4.23047   -33.50149 1.000 41.60733 ? 350 ARG   A CA  1 
ATOM   2116 C  C   . ARG   A 1 350 ? -45.33714 2.94964   -33.95272 1.000 44.17073 ? 350 ARG   A C   1 
ATOM   2117 O  O   . ARG   A 1 350 ? -45.39743 2.68646   -35.16017 1.000 47.98383 ? 350 ARG   A O   1 
ATOM   2118 C  CB  . ARG   A 1 350 ? -43.21225 4.24604   -34.02228 1.000 40.02801 ? 350 ARG   A CB  1 
ATOM   2119 C  CG  . ARG   A 1 350 ? -42.54969 5.61788   -33.98739 1.000 43.65901 ? 350 ARG   A CG  1 
ATOM   2120 C  CD  . ARG   A 1 350 ? -41.15430 5.54050   -34.56704 1.000 40.07209 ? 350 ARG   A CD  1 
ATOM   2121 N  NE  . ARG   A 1 350 ? -40.56965 6.86036   -34.74801 1.000 35.85697 ? 350 ARG   A NE  1 
ATOM   2122 C  CZ  . ARG   A 1 350 ? -40.40094 7.45210   -35.92779 1.000 34.28234 ? 350 ARG   A CZ  1 
ATOM   2123 N  NH1 . ARG   A 1 350 ? -40.76961 6.84113   -37.04857 1.000 25.93291 ? 350 ARG   A NH1 1 
ATOM   2124 N  NH2 . ARG   A 1 350 ? -39.85263 8.65741   -35.98196 1.000 36.34312 ? 350 ARG   A NH2 1 
ATOM   2125 N  N   . GLY   A 1 351 ? -45.83379 2.13354   -33.03218 1.000 44.06906 ? 351 GLY   A N   1 
ATOM   2126 C  CA  . GLY   A 1 351 ? -46.39815 0.86657   -33.43267 1.000 43.36237 ? 351 GLY   A CA  1 
ATOM   2127 C  C   . GLY   A 1 351 ? -45.40173 -0.14054  -33.95204 1.000 45.04020 ? 351 GLY   A C   1 
ATOM   2128 O  O   . GLY   A 1 351 ? -45.80298 -1.26142  -34.29084 1.000 43.37253 ? 351 GLY   A O   1 
ATOM   2129 N  N   . MET   A 1 352 ? -44.12280 0.21804   -34.04060 1.000 41.03432 ? 352 MET   A N   1 
ATOM   2130 C  CA  . MET   A 1 352 ? -43.10204 -0.76819  -34.34447 1.000 40.82854 ? 352 MET   A CA  1 
ATOM   2131 C  C   . MET   A 1 352 ? -42.97738 -1.74077  -33.18108 1.000 36.82567 ? 352 MET   A C   1 
ATOM   2132 O  O   . MET   A 1 352 ? -43.32032 -1.42660  -32.04134 1.000 35.43760 ? 352 MET   A O   1 
ATOM   2133 C  CB  . MET   A 1 352 ? -41.74759 -0.10400  -34.58711 1.000 39.51071 ? 352 MET   A CB  1 
ATOM   2134 C  CG  . MET   A 1 352 ? -41.77275 1.15985   -35.40169 1.000 36.59197 ? 352 MET   A CG  1 
ATOM   2135 S  SD  . MET   A 1 352 ? -40.20719 2.02681   -35.17706 1.000 38.49357 ? 352 MET   A SD  1 
ATOM   2136 C  CE  . MET   A 1 352 ? -39.07276 0.65962   -35.50936 1.000 24.76280 ? 352 MET   A CE  1 
ATOM   2137 N  N   . GLU   A 1 353 ? -42.47293 -2.93332  -33.47137 1.000 39.07143 ? 353 GLU   A N   1 
ATOM   2138 C  CA  . GLU   A 1 353 ? -42.20989 -3.85809  -32.38239 1.000 44.93691 ? 353 GLU   A CA  1 
ATOM   2139 C  C   . GLU   A 1 353 ? -40.98089 -3.41333  -31.59521 1.000 46.54781 ? 353 GLU   A C   1 
ATOM   2140 O  O   . GLU   A 1 353 ? -40.12068 -2.67913  -32.08991 1.000 45.92085 ? 353 GLU   A O   1 
ATOM   2141 C  CB  . GLU   A 1 353 ? -42.01870 -5.27806  -32.90622 1.000 48.52007 ? 353 GLU   A CB  1 
ATOM   2142 C  CG  . GLU   A 1 353 ? -40.87236 -5.44622  -33.86655 1.000 53.24322 ? 353 GLU   A CG  1 
ATOM   2143 C  CD  . GLU   A 1 353 ? -41.14284 -6.54561  -34.87049 1.000 66.44026 ? 353 GLU   A CD  1 
ATOM   2144 O  OE1 . GLU   A 1 353 ? -42.04603 -6.35957  -35.71750 1.000 69.74545 ? 353 GLU   A OE1 1 
ATOM   2145 O  OE2 . GLU   A 1 353 ? -40.47065 -7.59929  -34.80213 1.000 66.03589 ? 353 GLU   A OE2 1 
ATOM   2146 N  N   . ILE   A 1 354 ? -40.91321 -3.85098  -30.34527 1.000 45.23288 ? 354 ILE   A N   1 
ATOM   2147 C  CA  . ILE   A 1 354 ? -39.78621 -3.49498  -29.49408 1.000 41.55147 ? 354 ILE   A CA  1 
ATOM   2148 C  C   . ILE   A 1 354 ? -38.60567 -4.37870  -29.85139 1.000 40.76493 ? 354 ILE   A C   1 
ATOM   2149 O  O   . ILE   A 1 354 ? -38.75386 -5.59486  -30.02605 1.000 41.00751 ? 354 ILE   A O   1 
ATOM   2150 C  CB  . ILE   A 1 354 ? -40.15582 -3.62402  -28.01241 1.000 43.06473 ? 354 ILE   A CB  1 
ATOM   2151 C  CG1 . ILE   A 1 354 ? -41.38235 -2.77462  -27.75942 1.000 37.86332 ? 354 ILE   A CG1 1 
ATOM   2152 C  CG2 . ILE   A 1 354 ? -39.00294 -3.17366  -27.12383 1.000 36.21072 ? 354 ILE   A CG2 1 
ATOM   2153 C  CD1 . ILE   A 1 354 ? -42.07554 -3.00735  -26.45629 1.000 46.77327 ? 354 ILE   A CD1 1 
ATOM   2154 N  N   . SER   A 1 355 ? -37.43635 -3.75565  -29.99291 1.000 44.56780 ? 355 SER   A N   1 
ATOM   2155 C  CA  . SER   A 1 355 ? -36.20840 -4.48128  -30.22685 1.000 40.21526 ? 355 SER   A CA  1 
ATOM   2156 C  C   . SER   A 1 355 ? -35.84220 -5.27532  -28.97850 1.000 40.33992 ? 355 SER   A C   1 
ATOM   2157 O  O   . SER   A 1 355 ? -36.35987 -5.01195  -27.89286 1.000 46.96858 ? 355 SER   A O   1 
ATOM   2158 C  CB  . SER   A 1 355 ? -35.09357 -3.50542  -30.59143 1.000 40.60222 ? 355 SER   A CB  1 
ATOM   2159 O  OG  . SER   A 1 355 ? -35.56813 -2.55761  -31.53428 1.000 35.10586 ? 355 SER   A OG  1 
ATOM   2160 N  N   . PRO   A 1 356 ? -34.97424 -6.27264  -29.10902 1.000 45.24455 ? 356 PRO   A N   1 
ATOM   2161 C  CA  . PRO   A 1 356 ? -34.50196 -6.98088  -27.91582 1.000 38.53853 ? 356 PRO   A CA  1 
ATOM   2162 C  C   . PRO   A 1 356 ? -33.97702 -6.00551  -26.87384 1.000 45.79554 ? 356 PRO   A C   1 
ATOM   2163 O  O   . PRO   A 1 356 ? -33.39637 -4.96374  -27.19598 1.000 38.71614 ? 356 PRO   A O   1 
ATOM   2164 C  CB  . PRO   A 1 356 ? -33.39303 -7.88488  -28.45970 1.000 50.59203 ? 356 PRO   A CB  1 
ATOM   2165 C  CG  . PRO   A 1 356 ? -33.84194 -8.18448  -29.86728 1.000 50.26159 ? 356 PRO   A CG  1 
ATOM   2166 C  CD  . PRO   A 1 356 ? -34.52995 -6.91909  -30.35817 1.000 44.90595 ? 356 PRO   A CD  1 
ATOM   2167 N  N   . MET   A 1 357 ? -34.23250 -6.33291  -25.61020 1.000 43.93345 ? 357 MET   A N   1 
ATOM   2168 C  CA  . MET   A 1 357 ? -33.68011 -5.65342  -24.44555 1.000 40.86877 ? 357 MET   A CA  1 
ATOM   2169 C  C   . MET   A 1 357 ? -34.14277 -4.20810  -24.31802 1.000 36.10875 ? 357 MET   A C   1 
ATOM   2170 O  O   . MET   A 1 357 ? -33.59461 -3.46532  -23.49089 1.000 36.08038 ? 357 MET   A O   1 
ATOM   2171 C  CB  . MET   A 1 357 ? -32.14212 -5.68589  -24.43863 1.000 40.32232 ? 357 MET   A CB  1 
ATOM   2172 C  CG  . MET   A 1 357 ? -31.48134 -6.94148  -25.04374 1.000 48.11192 ? 357 MET   A CG  1 
ATOM   2173 S  SD  . MET   A 1 357 ? -31.95249 -8.52605  -24.31086 1.000 73.23449 ? 357 MET   A SD  1 
ATOM   2174 C  CE  . MET   A 1 357 ? -31.05780 -9.67548  -25.34728 1.000 60.14055 ? 357 MET   A CE  1 
ATOM   2175 N  N   . CYS   A 1 358 ? -35.12851 -3.77593  -25.10206 1.000 34.30350 ? 358 CYS   A N   1 
ATOM   2176 C  CA  . CYS   A 1 358 ? -35.54087 -2.37858  -25.10422 1.000 31.75474 ? 358 CYS   A CA  1 
ATOM   2177 C  C   . CYS   A 1 358 ? -36.88987 -2.15326  -24.43247 1.000 34.61050 ? 358 CYS   A C   1 
ATOM   2178 O  O   . CYS   A 1 358 ? -37.39118 -1.02259  -24.43843 1.000 31.27916 ? 358 CYS   A O   1 
ATOM   2179 C  CB  . CYS   A 1 358 ? -35.57397 -1.84005  -26.53771 1.000 33.61928 ? 358 CYS   A CB  1 
ATOM   2180 S  SG  . CYS   A 1 358 ? -33.92976 -1.64995  -27.31437 1.000 29.57875 ? 358 CYS   A SG  1 
ATOM   2181 N  N   . ASP   A 1 359 ? -37.48741 -3.19121  -23.85397 1.000 38.00917 ? 359 ASP   A N   1 
ATOM   2182 C  CA  . ASP   A 1 359 ? -38.84819 -3.12712  -23.32139 1.000 37.14243 ? 359 ASP   A CA  1 
ATOM   2183 C  C   . ASP   A 1 359 ? -38.78521 -3.05127  -21.80140 1.000 32.99528 ? 359 ASP   A C   1 
ATOM   2184 O  O   . ASP   A 1 359 ? -38.53654 -4.05809  -21.13276 1.000 41.06790 ? 359 ASP   A O   1 
ATOM   2185 C  CB  . ASP   A 1 359 ? -39.65409 -4.33904  -23.76748 1.000 39.62984 ? 359 ASP   A CB  1 
ATOM   2186 C  CG  . ASP   A 1 359 ? -41.13556 -4.17807  -23.50940 1.000 45.38177 ? 359 ASP   A CG  1 
ATOM   2187 O  OD1 . ASP   A 1 359 ? -41.53565 -3.23126  -22.78220 1.000 33.37828 ? 359 ASP   A OD1 1 
ATOM   2188 O  OD2 . ASP   A 1 359 ? -41.89710 -5.00900  -24.04826 1.000 48.74346 ? 359 ASP   A OD2 1 
ATOM   2189 N  N   . LYS   A 1 360 ? -39.04755 -1.86234  -21.25767 1.000 34.18691 ? 360 LYS   A N   1 
ATOM   2190 C  CA  . LYS   A 1 360 ? -38.98898 -1.67006  -19.81236 1.000 34.84845 ? 360 LYS   A CA  1 
ATOM   2191 C  C   . LYS   A 1 360 ? -39.97770 -2.55297  -19.04726 1.000 42.39414 ? 360 LYS   A C   1 
ATOM   2192 O  O   . LYS   A 1 360 ? -39.80246 -2.74278  -17.83767 1.000 35.71314 ? 360 LYS   A O   1 
ATOM   2193 C  CB  . LYS   A 1 360 ? -39.22888 -0.19376  -19.48231 1.000 36.17122 ? 360 LYS   A CB  1 
ATOM   2194 C  CG  . LYS   A 1 360 ? -40.54753 0.37514   -20.03729 1.000 47.98559 ? 360 LYS   A CG  1 
ATOM   2195 C  CD  . LYS   A 1 360 ? -40.44325 1.88382   -20.29012 1.000 41.56085 ? 360 LYS   A CD  1 
ATOM   2196 C  CE  . LYS   A 1 360 ? -41.43521 2.67083   -19.45998 1.000 37.94838 ? 360 LYS   A CE  1 
ATOM   2197 N  NZ  . LYS   A 1 360 ? -41.08252 4.11718   -19.37032 1.000 29.84573 ? 360 LYS   A NZ  1 
ATOM   2198 N  N   . HIS   A 1 361 ? -41.00615 -3.09368  -19.70984 1.000 36.66630 ? 361 HIS   A N   1 
ATOM   2199 C  CA  . HIS   A 1 361 ? -41.99683 -3.94847  -19.05485 1.000 44.97407 ? 361 HIS   A CA  1 
ATOM   2200 C  C   . HIS   A 1 361 ? -41.70534 -5.42579  -19.24242 1.000 43.96230 ? 361 HIS   A C   1 
ATOM   2201 O  O   . HIS   A 1 361 ? -42.47251 -6.27175  -18.77606 1.000 54.58751 ? 361 HIS   A O   1 
ATOM   2202 C  CB  . HIS   A 1 361 ? -43.40772 -3.63087  -19.57351 1.000 43.39772 ? 361 HIS   A CB  1 
ATOM   2203 C  CG  . HIS   A 1 361 ? -43.76338 -2.17697  -19.48930 1.000 45.13987 ? 361 HIS   A CG  1 
ATOM   2204 N  ND1 . HIS   A 1 361 ? -43.69572 -1.46069  -18.31187 1.000 44.16043 ? 361 HIS   A ND1 1 
ATOM   2205 C  CD2 . HIS   A 1 361 ? -44.16893 -1.30016  -20.43839 1.000 41.49950 ? 361 HIS   A CD2 1 
ATOM   2206 C  CE1 . HIS   A 1 361 ? -44.05190 -0.20808  -18.53608 1.000 39.31504 ? 361 HIS   A CE1 1 
ATOM   2207 N  NE2 . HIS   A 1 361 ? -44.34147 -0.08347  -19.81940 1.000 52.40161 ? 361 HIS   A NE2 1 
ATOM   2208 N  N   . ASN   A 1 362 ? -40.62120 -5.74860  -19.92308 1.000 43.99096 ? 362 ASN   A N   1 
ATOM   2209 C  CA  . ASN   A 1 362 ? -40.23617 -7.12804  -20.16878 1.000 52.48503 ? 362 ASN   A CA  1 
ATOM   2210 C  C   . ASN   A 1 362 ? -38.71567 -7.20013  -20.19029 1.000 52.71323 ? 362 ASN   A C   1 
ATOM   2211 O  O   . ASN   A 1 362 ? -38.11129 -7.83355  -21.06245 1.000 47.29822 ? 362 ASN   A O   1 
ATOM   2212 C  CB  . ASN   A 1 362 ? -40.85829 -7.64861  -21.46842 1.000 56.41239 ? 362 ASN   A CB  1 
ATOM   2213 C  CG  . ASN   A 1 362 ? -40.53096 -9.10803  -21.75176 1.000 63.01583 ? 362 ASN   A CG  1 
ATOM   2214 O  OD1 . ASN   A 1 362 ? -39.85490 -9.78378  -20.97406 1.000 67.82527 ? 362 ASN   A OD1 1 
ATOM   2215 N  ND2 . ASN   A 1 362 ? -41.00974 -9.59611  -22.88606 1.000 66.35532 ? 362 ASN   A ND2 1 
ATOM   2216 N  N   . ALA   A 1 363 ? -38.08778 -6.51010  -19.24549 1.000 44.56726 ? 363 ALA   A N   1 
ATOM   2217 C  CA  . ALA   A 1 363 ? -36.64321 -6.47055  -19.14420 1.000 44.61551 ? 363 ALA   A CA  1 
ATOM   2218 C  C   . ALA   A 1 363 ? -36.13281 -7.61739  -18.27591 1.000 42.02990 ? 363 ALA   A C   1 
ATOM   2219 O  O   . ALA   A 1 363 ? -36.84610 -8.17230  -17.43818 1.000 48.25372 ? 363 ALA   A O   1 
ATOM   2220 C  CB  . ALA   A 1 363 ? -36.18760 -5.12928  -18.57485 1.000 38.20339 ? 363 ALA   A CB  1 
ATOM   2221 N  N   . SER   A 1 364 ? -34.87754 -7.97973  -18.50960 1.000 37.95809 ? 364 SER   A N   1 
ATOM   2222 C  CA  . SER   A 1 364 ? -34.13019 -8.92934  -17.69818 1.000 35.91838 ? 364 SER   A CA  1 
ATOM   2223 C  C   . SER   A 1 364 ? -32.67458 -8.46544  -17.80053 1.000 24.65800 ? 364 SER   A C   1 
ATOM   2224 O  O   . SER   A 1 364 ? -31.86684 -8.95254  -18.59403 1.000 24.98749 ? 364 SER   A O   1 
ATOM   2225 C  CB  . SER   A 1 364 ? -34.32244 -10.36305 -18.17803 1.000 29.50708 ? 364 SER   A CB  1 
ATOM   2226 O  OG  . SER   A 1 364 ? -34.38418 -10.35815 -19.58713 1.000 39.95671 ? 364 SER   A OG  1 
ATOM   2227 N  N   . VAL   A 1 365 ? -32.35046 -7.45841  -17.00501 1.000 24.15014 ? 365 VAL   A N   1 
ATOM   2228 C  CA  . VAL   A 1 365 ? -31.08025 -6.77111  -17.17475 1.000 21.31848 ? 365 VAL   A CA  1 
ATOM   2229 C  C   . VAL   A 1 365 ? -29.92635 -7.70492  -16.85953 1.000 23.73955 ? 365 VAL   A C   1 
ATOM   2230 O  O   . VAL   A 1 365 ? -28.94683 -7.77533  -17.61642 1.000 17.99606 ? 365 VAL   A O   1 
ATOM   2231 C  CB  . VAL   A 1 365 ? -31.05854 -5.50638  -16.30348 1.000 18.35918 ? 365 VAL   A CB  1 
ATOM   2232 C  CG1 . VAL   A 1 365 ? -29.62372 -4.98432  -16.09282 1.000 15.15883 ? 365 VAL   A CG1 1 
ATOM   2233 C  CG2 . VAL   A 1 365 ? -31.93847 -4.46257  -16.95433 1.000 23.20187 ? 365 VAL   A CG2 1 
ATOM   2234 N  N   . GLU   A 1 366 ? -30.03608 -8.45469  -15.75591 1.000 15.27443 ? 366 GLU   A N   1 
ATOM   2235 C  CA  . GLU   A 1 366 ? -28.94282 -9.31888  -15.34089 1.000 15.97182 ? 366 GLU   A CA  1 
ATOM   2236 C  C   . GLU   A 1 366 ? -28.68893 -10.40732 -16.37850 1.000 21.29204 ? 366 GLU   A C   1 
ATOM   2237 O  O   . GLU   A 1 366 ? -27.54984 -10.60592 -16.81197 1.000 21.72126 ? 366 GLU   A O   1 
ATOM   2238 C  CB  . GLU   A 1 366 ? -29.23522 -9.90964  -13.95538 1.000 24.57035 ? 366 GLU   A CB  1 
ATOM   2239 C  CG  . GLU   A 1 366 ? -29.41251 -8.86098  -12.83426 1.000 22.41625 ? 366 GLU   A CG  1 
ATOM   2240 C  CD  . GLU   A 1 366 ? -30.73151 -8.09399  -12.90368 1.000 20.31933 ? 366 GLU   A CD  1 
ATOM   2241 O  OE1 . GLU   A 1 366 ? -30.80819 -6.97113  -12.34305 1.000 25.09542 ? 366 GLU   A OE1 1 
ATOM   2242 O  OE2 . GLU   A 1 366 ? -31.69446 -8.60246  -13.52354 1.000 22.85041 ? 366 GLU   A OE2 1 
ATOM   2243 N  N   . LYS   A 1 367 ? -29.74377 -11.10974 -16.81300 1.000 19.36179 ? 367 LYS   A N   1 
ATOM   2244 C  CA  . LYS   A 1 367 ? -29.55178 -12.14568 -17.82559 1.000 25.29133 ? 367 LYS   A CA  1 
ATOM   2245 C  C   . LYS   A 1 367 ? -29.08023 -11.56452 -19.15669 1.000 20.39227 ? 367 LYS   A C   1 
ATOM   2246 O  O   . LYS   A 1 367 ? -28.38823 -12.24661 -19.92515 1.000 18.65826 ? 367 LYS   A O   1 
ATOM   2247 C  CB  . LYS   A 1 367 ? -30.84168 -12.93714 -18.03536 1.000 26.70066 ? 367 LYS   A CB  1 
ATOM   2248 C  CG  . LYS   A 1 367 ? -31.49304 -13.39296 -16.74727 1.000 36.48740 ? 367 LYS   A CG  1 
ATOM   2249 C  CD  . LYS   A 1 367 ? -32.86063 -14.00702 -17.00210 1.000 34.32343 ? 367 LYS   A CD  1 
ATOM   2250 C  CE  . LYS   A 1 367 ? -32.88907 -14.77944 -18.31350 1.000 33.80181 ? 367 LYS   A CE  1 
ATOM   2251 N  NZ  . LYS   A 1 367 ? -34.19235 -15.49019 -18.47498 1.000 32.10660 ? 367 LYS   A NZ  1 
ATOM   2252 N  N   . SER   A 1 368 ? -29.44160 -10.31944 -19.45041 1.000 17.96108 ? 368 SER   A N   1 
ATOM   2253 C  CA  . SER   A 1 368 ? -28.92831 -9.68604  -20.65864 1.000 21.69985 ? 368 SER   A CA  1 
ATOM   2254 C  C   . SER   A 1 368 ? -27.43543 -9.42290  -20.54716 1.000 16.31003 ? 368 SER   A C   1 
ATOM   2255 O  O   . SER   A 1 368 ? -26.69250 -9.65234  -21.50199 1.000 22.26275 ? 368 SER   A O   1 
ATOM   2256 C  CB  . SER   A 1 368 ? -29.68849 -8.39472  -20.94610 1.000 18.05030 ? 368 SER   A CB  1 
ATOM   2257 O  OG  . SER   A 1 368 ? -31.01964 -8.70353  -21.30269 1.000 24.00046 ? 368 SER   A OG  1 
ATOM   2258 N  N   . GLN   A 1 369 ? -26.97068 -8.97031  -19.38795 1.000 14.96004 ? 369 GLN   A N   1 
ATOM   2259 C  CA  . GLN   A 1 369 ? -25.53469 -8.77270  -19.21043 1.000 14.86847 ? 369 GLN   A CA  1 
ATOM   2260 C  C   . GLN   A 1 369 ? -24.77826 -10.09223 -19.31125 1.000 17.78499 ? 369 GLN   A C   1 
ATOM   2261 O  O   . GLN   A 1 369 ? -23.72665 -10.16792 -19.96866 1.000 17.27273 ? 369 GLN   A O   1 
ATOM   2262 C  CB  . GLN   A 1 369 ? -25.26155 -8.09053  -17.87345 1.000 14.96180 ? 369 GLN   A CB  1 
ATOM   2263 C  CG  . GLN   A 1 369 ? -25.64896 -6.63167  -17.86794 1.000 12.74754 ? 369 GLN   A CG  1 
ATOM   2264 C  CD  . GLN   A 1 369 ? -24.96398 -5.89334  -18.98361 1.000 13.14569 ? 369 GLN   A CD  1 
ATOM   2265 O  OE1 . GLN   A 1 369 ? -23.75449 -5.99882  -19.13961 1.000 11.89570 ? 369 GLN   A OE1 1 
ATOM   2266 N  NE2 . GLN   A 1 369 ? -25.73868 -5.18434  -19.80455 1.000 12.28040 ? 369 GLN   A NE2 1 
ATOM   2267 N  N   . VAL   A 1 370 ? -25.30644 -11.14913 -18.68462 1.000 16.84118 ? 370 VAL   A N   1 
ATOM   2268 C  CA  . VAL   A 1 370 ? -24.64948 -12.45677 -18.73951 1.000 15.94526 ? 370 VAL   A CA  1 
ATOM   2269 C  C   . VAL   A 1 370 ? -24.56836 -12.95706 -20.17764 1.000 14.11762 ? 370 VAL   A C   1 
ATOM   2270 O  O   . VAL   A 1 370 ? -23.52504 -13.44142 -20.62754 1.000 13.08778 ? 370 VAL   A O   1 
ATOM   2271 C  CB  . VAL   A 1 370 ? -25.38174 -13.46825 -17.84325 1.000 19.27095 ? 370 VAL   A CB  1 
ATOM   2272 C  CG1 . VAL   A 1 370 ? -24.76182 -14.84200 -18.03454 1.000 20.71283 ? 370 VAL   A CG1 1 
ATOM   2273 C  CG2 . VAL   A 1 370 ? -25.31343 -13.04066 -16.39403 1.000 22.74285 ? 370 VAL   A CG2 1 
ATOM   2274 N  N   . GLY   A 1 371 ? -25.67311 -12.85822 -20.91813 1.000 19.18933 ? 371 GLY   A N   1 
ATOM   2275 C  CA  . GLY   A 1 371 ? -25.63112 -13.21493 -22.32980 1.000 18.48454 ? 371 GLY   A CA  1 
ATOM   2276 C  C   . GLY   A 1 371 ? -24.68456 -12.33388 -23.12515 1.000 16.30227 ? 371 GLY   A C   1 
ATOM   2277 O  O   . GLY   A 1 371 ? -23.97520 -12.81127 -24.01014 1.000 16.36374 ? 371 GLY   A O   1 
ATOM   2278 N  N   . PHE   A 1 372 ? -24.67179 -11.03260 -22.81493 1.000 14.30824 ? 372 PHE   A N   1 
ATOM   2279 C  CA  . PHE   A 1 372 ? -23.77337 -10.09123 -23.46494 1.000 15.33513 ? 372 PHE   A CA  1 
ATOM   2280 C  C   . PHE   A 1 372 ? -22.32490 -10.46818 -23.21417 1.000 12.48167 ? 372 PHE   A C   1 
ATOM   2281 O  O   . PHE   A 1 372 ? -21.49064 -10.40848 -24.12471 1.000 15.90807 ? 372 PHE   A O   1 
ATOM   2282 C  CB  . PHE   A 1 372 ? -24.07695 -8.67337  -22.95190 1.000 15.21469 ? 372 PHE   A CB  1 
ATOM   2283 C  CG  . PHE   A 1 372 ? -23.25108 -7.57688  -23.58673 1.000 15.94149 ? 372 PHE   A CG  1 
ATOM   2284 C  CD1 . PHE   A 1 372 ? -23.20447 -7.42324  -24.95979 1.000 18.49951 ? 372 PHE   A CD1 1 
ATOM   2285 C  CD2 . PHE   A 1 372 ? -22.56676 -6.66184  -22.79320 1.000 15.56225 ? 372 PHE   A CD2 1 
ATOM   2286 C  CE1 . PHE   A 1 372 ? -22.46345 -6.39667  -25.54204 1.000 16.73910 ? 372 PHE   A CE1 1 
ATOM   2287 C  CE2 . PHE   A 1 372 ? -21.84306 -5.62538  -23.36282 1.000 17.39140 ? 372 PHE   A CE2 1 
ATOM   2288 C  CZ  . PHE   A 1 372 ? -21.79571 -5.49331  -24.75031 1.000 18.64726 ? 372 PHE   A CZ  1 
ATOM   2289 N  N   . ILE   A 1 373 ? -22.00432 -10.86215 -21.98291 1.000 17.94523 ? 373 ILE   A N   1 
ATOM   2290 C  CA  . ILE   A 1 373 ? -20.63978 -11.28188 -21.67749 1.000 19.80391 ? 373 ILE   A CA  1 
ATOM   2291 C  C   . ILE   A 1 373 ? -20.32315 -12.58324 -22.39568 1.000 16.53891 ? 373 ILE   A C   1 
ATOM   2292 O  O   . ILE   A 1 373 ? -19.27922 -12.71665 -23.04447 1.000 19.07961 ? 373 ILE   A O   1 
ATOM   2293 C  CB  . ILE   A 1 373 ? -20.43812 -11.41287 -20.15425 1.000 15.95779 ? 373 ILE   A CB  1 
ATOM   2294 C  CG1 . ILE   A 1 373 ? -20.51974 -10.04226 -19.47783 1.000 19.43388 ? 373 ILE   A CG1 1 
ATOM   2295 C  CG2 . ILE   A 1 373 ? -19.09184 -12.05028 -19.83861 1.000 16.12649 ? 373 ILE   A CG2 1 
ATOM   2296 C  CD1 . ILE   A 1 373 ? -20.24727 -10.09453 -17.98760 1.000 14.21720 ? 373 ILE   A CD1 1 
ATOM   2297 N  N   . ASP   A 1 374 ? -21.24999 -13.53676 -22.33600 1.000 18.92598 ? 374 ASP   A N   1 
ATOM   2298 C  CA  . ASP   A 1 374 ? -20.96702 -14.89756 -22.78603 1.000 19.69272 ? 374 ASP   A CA  1 
ATOM   2299 C  C   . ASP   A 1 374 ? -20.77194 -14.96944 -24.29675 1.000 19.95243 ? 374 ASP   A C   1 
ATOM   2300 O  O   . ASP   A 1 374 ? -19.85533 -15.65109 -24.76974 1.000 21.46332 ? 374 ASP   A O   1 
ATOM   2301 C  CB  . ASP   A 1 374 ? -22.09380 -15.83453 -22.36098 1.000 18.38328 ? 374 ASP   A CB  1 
ATOM   2302 C  CG  . ASP   A 1 374 ? -22.08086 -16.13747 -20.87581 1.000 17.15830 ? 374 ASP   A CG  1 
ATOM   2303 O  OD1 . ASP   A 1 374 ? -21.04961 -15.91705 -20.23428 1.000 17.67395 ? 374 ASP   A OD1 1 
ATOM   2304 O  OD2 . ASP   A 1 374 ? -23.11445 -16.61272 -20.36079 1.000 19.42217 ? 374 ASP   A OD2 1 
ATOM   2305 N  N   . TYR   A 1 375 ? -21.61619 -14.27374 -25.06566 1.000 15.94887 ? 375 TYR   A N   1 
ATOM   2306 C  CA  . TYR   A 1 375 ? -21.61610 -14.37290 -26.52531 1.000 19.97351 ? 375 TYR   A CA  1 
ATOM   2307 C  C   . TYR   A 1 375 ? -20.80951 -13.28642 -27.22016 1.000 20.32723 ? 375 TYR   A C   1 
ATOM   2308 O  O   . TYR   A 1 375 ? -20.34857 -13.51108 -28.34104 1.000 19.10266 ? 375 TYR   A O   1 
ATOM   2309 C  CB  . TYR   A 1 375 ? -23.06099 -14.33723 -27.06897 1.000 23.69941 ? 375 TYR   A CB  1 
ATOM   2310 C  CG  . TYR   A 1 375 ? -23.77958 -15.66056 -26.88177 1.000 20.01503 ? 375 TYR   A CG  1 
ATOM   2311 C  CD1 . TYR   A 1 375 ? -24.22657 -16.06304 -25.61622 1.000 33.68213 ? 375 TYR   A CD1 1 
ATOM   2312 C  CD2 . TYR   A 1 375 ? -23.98776 -16.51780 -27.95109 1.000 24.24271 ? 375 TYR   A CD2 1 
ATOM   2313 C  CE1 . TYR   A 1 375 ? -24.85611 -17.29620 -25.42648 1.000 31.31468 ? 375 TYR   A CE1 1 
ATOM   2314 C  CE2 . TYR   A 1 375 ? -24.62544 -17.75606 -27.77072 1.000 33.45960 ? 375 TYR   A CE2 1 
ATOM   2315 C  CZ  . TYR   A 1 375 ? -25.05191 -18.13505 -26.50794 1.000 32.50713 ? 375 TYR   A CZ  1 
ATOM   2316 O  OH  . TYR   A 1 375 ? -25.68604 -19.34785 -26.32675 1.000 48.77941 ? 375 TYR   A OH  1 
ATOM   2317 N  N   . ILE   A 1 376 ? -20.62959 -12.11867 -26.60337 1.000 18.68980 ? 376 ILE   A N   1 
ATOM   2318 C  CA  . ILE   A 1 376 ? -19.94749 -11.02252 -27.28897 1.000 17.62182 ? 376 ILE   A CA  1 
ATOM   2319 C  C   . ILE   A 1 376 ? -18.65326 -10.67181 -26.56522 1.000 13.31326 ? 376 ILE   A C   1 
ATOM   2320 O  O   . ILE   A 1 376 ? -17.54922 -10.84810 -27.10136 1.000 14.62454 ? 376 ILE   A O   1 
ATOM   2321 C  CB  . ILE   A 1 376 ? -20.85663 -9.78228  -27.40299 1.000 12.56884 ? 376 ILE   A CB  1 
ATOM   2322 C  CG1 . ILE   A 1 376 ? -22.21226 -10.13682 -28.05031 1.000 17.77079 ? 376 ILE   A CG1 1 
ATOM   2323 C  CG2 . ILE   A 1 376 ? -20.13535 -8.67133  -28.17130 1.000 14.75401 ? 376 ILE   A CG2 1 
ATOM   2324 C  CD1 . ILE   A 1 376 ? -22.15435 -10.43529 -29.53132 1.000 21.51203 ? 376 ILE   A CD1 1 
ATOM   2325 N  N   . VAL   A 1 377 ? -18.79754 -10.18255 -25.32839 1.000 11.37386 ? 377 VAL   A N   1 
ATOM   2326 C  CA  . VAL   A 1 377 ? -17.71177 -9.49824  -24.63944 1.000 11.97945 ? 377 VAL   A CA  1 
ATOM   2327 C  C   . VAL   A 1 377 ? -16.58922 -10.46127 -24.27135 1.000 15.78377 ? 377 VAL   A C   1 
ATOM   2328 O  O   . VAL   A 1 377 ? -15.40154 -10.15170 -24.46319 1.000 12.26578 ? 377 VAL   A O   1 
ATOM   2329 C  CB  . VAL   A 1 377 ? -18.25984 -8.78228  -23.39542 1.000 16.27537 ? 377 VAL   A CB  1 
ATOM   2330 C  CG1 . VAL   A 1 377 ? -17.13242 -8.17079  -22.61396 1.000 9.12501  ? 377 VAL   A CG1 1 
ATOM   2331 C  CG2 . VAL   A 1 377 ? -19.27962 -7.72882  -23.82308 1.000 13.46183 ? 377 VAL   A CG2 1 
ATOM   2332 N  N   . HIS   A 1 378 ? -16.93636 -11.61572 -23.66431 1.000 13.67622 ? 378 HIS   A N   1 
ATOM   2333 C  CA  . HIS   A 1 378 ? -15.87760 -12.54191 -23.25741 1.000 16.65270 ? 378 HIS   A CA  1 
ATOM   2334 C  C   . HIS   A 1 378 ? -15.19037 -13.19826 -24.44744 1.000 16.44072 ? 378 HIS   A C   1 
ATOM   2335 O  O   . HIS   A 1 378 ? -13.94464 -13.26251 -24.45168 1.000 16.74645 ? 378 HIS   A O   1 
ATOM   2336 C  CB  . HIS   A 1 378 ? -16.40447 -13.58807 -22.27576 1.000 15.39411 ? 378 HIS   A CB  1 
ATOM   2337 C  CG  . HIS   A 1 378 ? -15.31547 -14.43663 -21.71022 1.000 18.82041 ? 378 HIS   A CG  1 
ATOM   2338 N  ND1 . HIS   A 1 378 ? -14.69213 -15.42557 -22.44292 1.000 11.98667 ? 378 HIS   A ND1 1 
ATOM   2339 C  CD2 . HIS   A 1 378 ? -14.68703 -14.39833 -20.51136 1.000 18.54886 ? 378 HIS   A CD2 1 
ATOM   2340 C  CE1 . HIS   A 1 378 ? -13.73556 -15.96850 -21.71487 1.000 21.69169 ? 378 HIS   A CE1 1 
ATOM   2341 N  NE2 . HIS   A 1 378 ? -13.71607 -15.36926 -20.53560 1.000 24.00439 ? 378 HIS   A NE2 1 
ATOM   2342 N  N   . PRO   A 1 379 ? -15.90411 -13.69186 -25.47446 1.000 14.64647 ? 379 PRO   A N   1 
ATOM   2343 C  CA  . PRO   A 1 379 ? -15.20742 -14.16650 -26.69104 1.000 14.35425 ? 379 PRO   A CA  1 
ATOM   2344 C  C   . PRO   A 1 379 ? -14.22087 -13.17108 -27.27779 1.000 15.63510 ? 379 PRO   A C   1 
ATOM   2345 O  O   . PRO   A 1 379 ? -13.10722 -13.55389 -27.67642 1.000 19.93513 ? 379 PRO   A O   1 
ATOM   2346 C  CB  . PRO   A 1 379 ? -16.36031 -14.42117 -27.66764 1.000 17.65516 ? 379 PRO   A CB  1 
ATOM   2347 C  CG  . PRO   A 1 379 ? -17.51279 -14.69524 -26.82927 1.000 15.34676 ? 379 PRO   A CG  1 
ATOM   2348 C  CD  . PRO   A 1 379 ? -17.36062 -13.86885 -25.58357 1.000 13.04597 ? 379 PRO   A CD  1 
ATOM   2349 N  N   . LEU   A 1 380 ? -14.60502 -11.89591 -27.34016 1.000 15.61227 ? 380 LEU   A N   1 
ATOM   2350 C  CA  . LEU   A 1 380 ? -13.72132 -10.86380 -27.87750 1.000 12.67613 ? 380 LEU   A CA  1 
ATOM   2351 C  C   . LEU   A 1 380 ? -12.49099 -10.69596 -27.00809 1.000 15.69660 ? 380 LEU   A C   1 
ATOM   2352 O  O   . LEU   A 1 380 ? -11.35729 -10.76384 -27.49632 1.000 15.77901 ? 380 LEU   A O   1 
ATOM   2353 C  CB  . LEU   A 1 380 ? -14.47855 -9.54153  -27.98586 1.000 13.11273 ? 380 LEU   A CB  1 
ATOM   2354 C  CG  . LEU   A 1 380 ? -13.66054 -8.32813  -28.41215 1.000 14.06520 ? 380 LEU   A CG  1 
ATOM   2355 C  CD1 . LEU   A 1 380 ? -13.17489 -8.51113  -29.83663 1.000 15.30739 ? 380 LEU   A CD1 1 
ATOM   2356 C  CD2 . LEU   A 1 380 ? -14.45328 -7.00822  -28.25899 1.000 13.29163 ? 380 LEU   A CD2 1 
ATOM   2357 N  N   . TRP   A 1 381 ? -12.69418 -10.49654 -25.70265 1.000 16.81970 ? 381 TRP   A N   1 
ATOM   2358 C  CA  . TRP   A 1 381 ? -11.57132 -10.17340 -24.82579 1.000 12.66563 ? 381 TRP   A CA  1 
ATOM   2359 C  C   . TRP   A 1 381 ? -10.66479 -11.36783 -24.57417 1.000 14.68007 ? 381 TRP   A C   1 
ATOM   2360 O  O   . TRP   A 1 381 ? -9.46509  -11.18077 -24.36748 1.000 17.49694 ? 381 TRP   A O   1 
ATOM   2361 C  CB  . TRP   A 1 381 ? -12.07768 -9.62873  -23.49430 1.000 12.06752 ? 381 TRP   A CB  1 
ATOM   2362 C  CG  . TRP   A 1 381 ? -12.30687 -8.16776  -23.55784 1.000 9.22198  ? 381 TRP   A CG  1 
ATOM   2363 C  CD1 . TRP   A 1 381 ? -13.47520 -7.53049  -23.85809 1.000 10.54265 ? 381 TRP   A CD1 1 
ATOM   2364 C  CD2 . TRP   A 1 381 ? -11.32604 -7.15467  -23.37300 1.000 7.71161  ? 381 TRP   A CD2 1 
ATOM   2365 N  NE1 . TRP   A 1 381 ? -13.28340 -6.17323  -23.85406 1.000 10.93142 ? 381 TRP   A NE1 1 
ATOM   2366 C  CE2 . TRP   A 1 381 ? -11.96931 -5.91512  -23.55234 1.000 8.46325  ? 381 TRP   A CE2 1 
ATOM   2367 C  CE3 . TRP   A 1 381 ? -9.96322  -7.17301  -23.06325 1.000 8.32592  ? 381 TRP   A CE3 1 
ATOM   2368 C  CZ2 . TRP   A 1 381 ? -11.29849 -4.69814  -23.42261 1.000 8.25104  ? 381 TRP   A CZ2 1 
ATOM   2369 C  CZ3 . TRP   A 1 381 ? -9.29515  -5.96236  -22.91358 1.000 9.63175  ? 381 TRP   A CZ3 1 
ATOM   2370 C  CH2 . TRP   A 1 381 ? -9.96373  -4.73951  -23.10653 1.000 11.23394 ? 381 TRP   A CH2 1 
ATOM   2371 N  N   . GLU   A 1 382 ? -11.22250 -12.58255 -24.51393 1.000 14.30217 ? 382 GLU   A N   1 
ATOM   2372 C  CA  . GLU   A 1 382 ? -10.38761 -13.78111 -24.47495 1.000 21.29761 ? 382 GLU   A CA  1 
ATOM   2373 C  C   . GLU   A 1 382 ? -9.45237  -13.82795 -25.67850 1.000 18.61798 ? 382 GLU   A C   1 
ATOM   2374 O  O   . GLU   A 1 382 ? -8.26659  -14.16883 -25.55255 1.000 20.05265 ? 382 GLU   A O   1 
ATOM   2375 C  CB  . GLU   A 1 382 ? -11.27616 -15.02947 -24.43262 1.000 17.40422 ? 382 GLU   A CB  1 
ATOM   2376 C  CG  . GLU   A 1 382 ? -10.55557 -16.35918 -24.27035 1.000 26.04873 ? 382 GLU   A CG  1 
ATOM   2377 C  CD  . GLU   A 1 382 ? -11.50783 -17.49389 -23.87227 1.000 36.15098 ? 382 GLU   A CD  1 
ATOM   2378 O  OE1 . GLU   A 1 382 ? -12.62624 -17.57633 -24.44635 1.000 31.29358 ? 382 GLU   A OE1 1 
ATOM   2379 O  OE2 . GLU   A 1 382 ? -11.14020 -18.29232 -22.97142 1.000 34.18441 ? 382 GLU   A OE2 1 
ATOM   2380 N  N   . THR   A 1 383 ? -9.96679  -13.46764 -26.85034 1.000 17.45039 ? 383 THR   A N   1 
ATOM   2381 C  CA  . THR   A 1 383 ? -9.14050  -13.45795 -28.04946 1.000 15.83021 ? 383 THR   A CA  1 
ATOM   2382 C  C   . THR   A 1 383 ? -8.08464  -12.36551 -27.96710 1.000 21.73732 ? 383 THR   A C   1 
ATOM   2383 O  O   . THR   A 1 383 ? -6.91028  -12.60733 -28.27120 1.000 16.43818 ? 383 THR   A O   1 
ATOM   2384 C  CB  . THR   A 1 383 ? -10.02614 -13.28615 -29.28451 1.000 16.57939 ? 383 THR   A CB  1 
ATOM   2385 O  OG1 . THR   A 1 383 ? -11.07970 -14.25051 -29.22759 1.000 19.48821 ? 383 THR   A OG1 1 
ATOM   2386 C  CG2 . THR   A 1 383 ? -9.22619  -13.49590 -30.57111 1.000 14.22650 ? 383 THR   A CG2 1 
ATOM   2387 N  N   . TRP   A 1 384 ? -8.47952  -11.15383 -27.52933 1.000 20.18030 ? 384 TRP   A N   1 
ATOM   2388 C  CA  . TRP   A 1 384 ? -7.48942  -10.10270 -27.32325 1.000 15.53092 ? 384 TRP   A CA  1 
ATOM   2389 C  C   . TRP   A 1 384 ? -6.45199  -10.54254 -26.31283 1.000 13.28860 ? 384 TRP   A C   1 
ATOM   2390 O  O   . TRP   A 1 384 ? -5.26501  -10.23064 -26.45600 1.000 12.42651 ? 384 TRP   A O   1 
ATOM   2391 C  CB  . TRP   A 1 384 ? -8.13180  -8.78795  -26.85758 1.000 12.99404 ? 384 TRP   A CB  1 
ATOM   2392 C  CG  . TRP   A 1 384 ? -7.10607  -7.69179  -26.62934 1.000 8.68675  ? 384 TRP   A CG  1 
ATOM   2393 C  CD1 . TRP   A 1 384 ? -6.49529  -7.38290  -25.45395 1.000 10.46565 ? 384 TRP   A CD1 1 
ATOM   2394 C  CD2 . TRP   A 1 384 ? -6.56523  -6.78431  -27.60994 1.000 9.32987  ? 384 TRP   A CD2 1 
ATOM   2395 N  NE1 . TRP   A 1 384 ? -5.61231  -6.34255  -25.63177 1.000 15.47469 ? 384 TRP   A NE1 1 
ATOM   2396 C  CE2 . TRP   A 1 384 ? -5.64330  -5.94920  -26.94238 1.000 10.42230 ? 384 TRP   A CE2 1 
ATOM   2397 C  CE3 . TRP   A 1 384 ? -6.79129  -6.58110  -28.97690 1.000 10.16451 ? 384 TRP   A CE3 1 
ATOM   2398 C  CZ2 . TRP   A 1 384 ? -4.93281  -4.93800  -27.59926 1.000 12.57428 ? 384 TRP   A CZ2 1 
ATOM   2399 C  CZ3 . TRP   A 1 384 ? -6.08728  -5.58750  -29.62987 1.000 10.59167 ? 384 TRP   A CZ3 1 
ATOM   2400 C  CH2 . TRP   A 1 384 ? -5.17316  -4.76944  -28.94579 1.000 11.29645 ? 384 TRP   A CH2 1 
ATOM   2401 N  N   . ALA   A 1 385 ? -6.88710  -11.25483 -25.27444 1.000 18.52706 ? 385 ALA   A N   1 
ATOM   2402 C  CA  . ALA   A 1 385 ? -5.96560  -11.65737 -24.21638 1.000 17.98207 ? 385 ALA   A CA  1 
ATOM   2403 C  C   . ALA   A 1 385 ? -4.93901  -12.65230 -24.73537 1.000 20.99089 ? 385 ALA   A C   1 
ATOM   2404 O  O   . ALA   A 1 385 ? -3.78399  -12.62278 -24.31285 1.000 24.18370 ? 385 ALA   A O   1 
ATOM   2405 C  CB  . ALA   A 1 385 ? -6.72860  -12.24671 -23.04035 1.000 9.73526  ? 385 ALA   A CB  1 
ATOM   2406 N  N   . ASP   A 1 386 ? -5.34451  -13.53734 -25.64970 1.000 21.18649 ? 386 ASP   A N   1 
ATOM   2407 C  CA  . ASP   A 1 386 ? -4.39203  -14.44993 -26.28093 1.000 25.55606 ? 386 ASP   A CA  1 
ATOM   2408 C  C   . ASP   A 1 386 ? -3.42354  -13.69903 -27.18233 1.000 23.30895 ? 386 ASP   A C   1 
ATOM   2409 O  O   . ASP   A 1 386 ? -2.22845  -14.01306 -27.21824 1.000 31.24624 ? 386 ASP   A O   1 
ATOM   2410 C  CB  . ASP   A 1 386 ? -5.12946  -15.52508 -27.07450 1.000 23.47984 ? 386 ASP   A CB  1 
ATOM   2411 C  CG  . ASP   A 1 386 ? -5.79186  -16.54355 -26.18521 1.000 23.88480 ? 386 ASP   A CG  1 
ATOM   2412 O  OD1 . ASP   A 1 386 ? -5.37077  -16.66987 -25.01063 1.000 30.85360 ? 386 ASP   A OD1 1 
ATOM   2413 O  OD2 . ASP   A 1 386 ? -6.73712  -17.21637 -26.65267 1.000 28.69827 ? 386 ASP   A OD2 1 
ATOM   2414 N  N   . LEU   A 1 387 ? -3.90866  -12.67857 -27.88499 1.000 27.60891 ? 387 LEU   A N   1 
ATOM   2415 C  CA  . LEU   A 1 387 ? -3.03132  -11.87894 -28.73389 1.000 17.20506 ? 387 LEU   A CA  1 
ATOM   2416 C  C   . LEU   A 1 387 ? -1.90851  -11.23915 -27.92799 1.000 24.40898 ? 387 LEU   A C   1 
ATOM   2417 O  O   . LEU   A 1 387 ? -0.74927  -11.22660 -28.35951 1.000 25.34742 ? 387 LEU   A O   1 
ATOM   2418 C  CB  . LEU   A 1 387 ? -3.83713  -10.80432 -29.44922 1.000 18.86405 ? 387 LEU   A CB  1 
ATOM   2419 C  CG  . LEU   A 1 387 ? -2.99476  -9.98661  -30.42096 1.000 21.99727 ? 387 LEU   A CG  1 
ATOM   2420 C  CD1 . LEU   A 1 387 ? -2.87823  -10.76117 -31.74763 1.000 25.77218 ? 387 LEU   A CD1 1 
ATOM   2421 C  CD2 . LEU   A 1 387 ? -3.58600  -8.60844  -30.62221 1.000 19.83372 ? 387 LEU   A CD2 1 
ATOM   2422 N  N   . VAL   A 1 388 ? -2.23356  -10.68118 -26.76630 1.000 19.61883 ? 388 VAL   A N   1 
ATOM   2423 C  CA  . VAL   A 1 388 ? -1.26955  -9.92302  -25.97512 1.000 21.00743 ? 388 VAL   A CA  1 
ATOM   2424 C  C   . VAL   A 1 388 ? -0.85653  -10.68484 -24.71731 1.000 17.66930 ? 388 VAL   A C   1 
ATOM   2425 O  O   . VAL   A 1 388 ? -0.31519  -10.09647 -23.78954 1.000 20.36476 ? 388 VAL   A O   1 
ATOM   2426 C  CB  . VAL   A 1 388 ? -1.80386  -8.52462  -25.62448 1.000 17.52821 ? 388 VAL   A CB  1 
ATOM   2427 C  CG1 . VAL   A 1 388 ? -2.09347  -7.73156  -26.88691 1.000 16.20413 ? 388 VAL   A CG1 1 
ATOM   2428 C  CG2 . VAL   A 1 388 ? -3.03987  -8.63425  -24.73717 1.000 18.39015 ? 388 VAL   A CG2 1 
ATOM   2429 N  N   . HIS   A 1 389 ? -1.11581  -11.98776 -24.68014 1.000 24.76514 ? 389 HIS   A N   1 
ATOM   2430 C  CA  . HIS   A 1 389 ? -0.82969  -12.81666 -23.51226 1.000 26.02369 ? 389 HIS   A CA  1 
ATOM   2431 C  C   . HIS   A 1 389 ? 0.58004   -12.58820 -22.96362 1.000 30.73627 ? 389 HIS   A C   1 
ATOM   2432 O  O   . HIS   A 1 389 ? 1.54920   -12.54155 -23.72460 1.000 26.25384 ? 389 HIS   A O   1 
ATOM   2433 C  CB  . HIS   A 1 389 ? -1.02169  -14.27886 -23.87318 1.000 26.42398 ? 389 HIS   A CB  1 
ATOM   2434 C  CG  . HIS   A 1 389 ? -1.30694  -15.14702 -22.69542 1.000 31.04939 ? 389 HIS   A CG  1 
ATOM   2435 N  ND1 . HIS   A 1 389 ? -0.32501  -15.54981 -21.81725 1.000 33.39754 ? 389 HIS   A ND1 1 
ATOM   2436 C  CD2 . HIS   A 1 389 ? -2.46496  -15.67416 -22.23456 1.000 29.79849 ? 389 HIS   A CD2 1 
ATOM   2437 C  CE1 . HIS   A 1 389 ? -0.86074  -16.29675 -20.86952 1.000 40.85633 ? 389 HIS   A CE1 1 
ATOM   2438 N  NE2 . HIS   A 1 389 ? -2.15804  -16.39209 -21.10164 1.000 45.76190 ? 389 HIS   A NE2 1 
ATOM   2439 N  N   . PRO   A 1 390 ? 0.69290   -12.42160 -21.63940 1.000 28.48149 ? 390 PRO   A N   1 
ATOM   2440 C  CA  . PRO   A 1 390 ? -0.40465  -12.45786 -20.67031 1.000 31.35744 ? 390 PRO   A CA  1 
ATOM   2441 C  C   . PRO   A 1 390 ? -0.82995  -11.05895 -20.22077 1.000 25.56735 ? 390 PRO   A C   1 
ATOM   2442 O  O   . PRO   A 1 390 ? -1.37872  -10.92343 -19.13761 1.000 22.09782 ? 390 PRO   A O   1 
ATOM   2443 C  CB  . PRO   A 1 390 ? 0.21864   -13.21643 -19.50662 1.000 29.21355 ? 390 PRO   A CB  1 
ATOM   2444 C  CG  . PRO   A 1 390 ? 1.64929   -12.67758 -19.49736 1.000 25.99527 ? 390 PRO   A CG  1 
ATOM   2445 C  CD  . PRO   A 1 390 ? 1.99681   -12.35440 -20.95434 1.000 32.10736 ? 390 PRO   A CD  1 
ATOM   2446 N  N   . ASP   A 1 391 ? -0.55900  -10.05495 -21.05944 1.000 22.65152 ? 391 ASP   A N   1 
ATOM   2447 C  CA  . ASP   A 1 391 ? -0.71972  -8.65573  -20.66895 1.000 26.87496 ? 391 ASP   A CA  1 
ATOM   2448 C  C   . ASP   A 1 391 ? -2.11869  -8.31740  -20.18632 1.000 16.35443 ? 391 ASP   A C   1 
ATOM   2449 O  O   . ASP   A 1 391 ? -2.28760  -7.35111  -19.44320 1.000 18.53561 ? 391 ASP   A O   1 
ATOM   2450 C  CB  . ASP   A 1 391 ? -0.40026  -7.73208  -21.84076 1.000 24.51846 ? 391 ASP   A CB  1 
ATOM   2451 C  CG  . ASP   A 1 391 ? 1.04595   -7.73438  -22.19744 1.000 27.04607 ? 391 ASP   A CG  1 
ATOM   2452 O  OD1 . ASP   A 1 391 ? 1.83673   -8.29087  -21.41154 1.000 28.48089 ? 391 ASP   A OD1 1 
ATOM   2453 O  OD2 . ASP   A 1 391 ? 1.38442   -7.14519  -23.24563 1.000 27.84906 ? 391 ASP   A OD2 1 
ATOM   2454 N  N   . ALA   A 1 392 ? -3.13317  -9.04660  -20.63254 1.000 21.75645 ? 392 ALA   A N   1 
ATOM   2455 C  CA  . ALA   A 1 392 ? -4.51214  -8.67256  -20.35595 1.000 20.40003 ? 392 ALA   A CA  1 
ATOM   2456 C  C   . ALA   A 1 392 ? -5.16859  -9.55435  -19.30672 1.000 16.80353 ? 392 ALA   A C   1 
ATOM   2457 O  O   . ALA   A 1 392 ? -6.38284  -9.44484  -19.09307 1.000 19.31415 ? 392 ALA   A O   1 
ATOM   2458 C  CB  . ALA   A 1 392 ? -5.32926  -8.69106  -21.64566 1.000 13.43210 ? 392 ALA   A CB  1 
ATOM   2459 N  N   . GLN   A 1 393 ? -4.39328  -10.39800 -18.62573 1.000 22.70433 ? 393 GLN   A N   1 
ATOM   2460 C  CA  . GLN   A 1 393 ? -4.97302  -11.38407 -17.71435 1.000 22.98229 ? 393 GLN   A CA  1 
ATOM   2461 C  C   . GLN   A 1 393 ? -5.82151  -10.73639 -16.62272 1.000 21.86722 ? 393 GLN   A C   1 
ATOM   2462 O  O   . GLN   A 1 393 ? -6.90585  -11.23614 -16.30198 1.000 22.92729 ? 393 GLN   A O   1 
ATOM   2463 C  CB  . GLN   A 1 393 ? -3.87117  -12.23960 -17.08094 1.000 26.46707 ? 393 GLN   A CB  1 
ATOM   2464 C  CG  . GLN   A 1 393 ? -4.41770  -13.42310 -16.24631 1.000 22.39633 ? 393 GLN   A CG  1 
ATOM   2465 C  CD  . GLN   A 1 393 ? -5.43577  -14.27237 -17.02008 1.000 34.28685 ? 393 GLN   A CD  1 
ATOM   2466 O  OE1 . GLN   A 1 393 ? -5.20848  -14.65524 -18.17956 1.000 34.04881 ? 393 GLN   A OE1 1 
ATOM   2467 N  NE2 . GLN   A 1 393 ? -6.56363  -14.56500 -16.38054 1.000 29.17666 ? 393 GLN   A NE2 1 
ATOM   2468 N  N   . ASP   A 1 394 ? -5.34380  -9.64290  -16.01927 1.000 17.34677 ? 394 ASP   A N   1 
ATOM   2469 C  CA  . ASP   A 1 394 ? -6.12490  -9.02621  -14.94804 1.000 19.11277 ? 394 ASP   A CA  1 
ATOM   2470 C  C   . ASP   A 1 394 ? -7.44319  -8.46930  -15.46567 1.000 15.11550 ? 394 ASP   A C   1 
ATOM   2471 O  O   . ASP   A 1 394 ? -8.42767  -8.41582  -14.72291 1.000 18.78998 ? 394 ASP   A O   1 
ATOM   2472 C  CB  . ASP   A 1 394 ? -5.31899  -7.92770  -14.25791 1.000 19.08552 ? 394 ASP   A CB  1 
ATOM   2473 C  CG  . ASP   A 1 394 ? -4.10349  -8.47414  -13.53099 1.000 27.61084 ? 394 ASP   A CG  1 
ATOM   2474 O  OD1 . ASP   A 1 394 ? -4.10562  -9.67724  -13.16971 1.000 27.62056 ? 394 ASP   A OD1 1 
ATOM   2475 O  OD2 . ASP   A 1 394 ? -3.14700  -7.69857  -13.32166 1.000 36.86268 ? 394 ASP   A OD2 1 
ATOM   2476 N  N   . ILE   A 1 395 ? -7.47801  -8.02792  -16.72141 1.000 16.32071 ? 395 ILE   A N   1 
ATOM   2477 C  CA  . ILE   A 1 395 ? -8.73290  -7.56556  -17.31801 1.000 13.22554 ? 395 ILE   A CA  1 
ATOM   2478 C  C   . ILE   A 1 395 ? -9.67402  -8.74033  -17.54757 1.000 13.94102 ? 395 ILE   A C   1 
ATOM   2479 O  O   . ILE   A 1 395 ? -10.87609 -8.66080  -17.26450 1.000 12.83266 ? 395 ILE   A O   1 
ATOM   2480 C  CB  . ILE   A 1 395 ? -8.45589  -6.82223  -18.63781 1.000 13.78080 ? 395 ILE   A CB  1 
ATOM   2481 C  CG1 . ILE   A 1 395 ? -7.57214  -5.58669  -18.45009 1.000 14.91310 ? 395 ILE   A CG1 1 
ATOM   2482 C  CG2 . ILE   A 1 395 ? -9.74380  -6.43379  -19.31982 1.000 12.24606 ? 395 ILE   A CG2 1 
ATOM   2483 C  CD1 . ILE   A 1 395 ? -7.15351  -4.98624  -19.80751 1.000 8.59225  ? 395 ILE   A CD1 1 
ATOM   2484 N  N   . LEU   A 1 396 ? -9.15154  -9.84574  -18.09304 1.000 15.91686 ? 396 LEU   A N   1 
ATOM   2485 C  CA  . LEU   A 1 396 ? -9.99725  -11.01550 -18.28399 1.000 15.43809 ? 396 LEU   A CA  1 
ATOM   2486 C  C   . LEU   A 1 396 ? -10.49295 -11.54606 -16.94365 1.000 19.56248 ? 396 LEU   A C   1 
ATOM   2487 O  O   . LEU   A 1 396 ? -11.63066 -12.03088 -16.84708 1.000 17.51393 ? 396 LEU   A O   1 
ATOM   2488 C  CB  . LEU   A 1 396 ? -9.23101  -12.08548 -19.06273 1.000 17.91198 ? 396 LEU   A CB  1 
ATOM   2489 C  CG  . LEU   A 1 396 ? -10.05271 -13.10967 -19.84262 1.000 21.13432 ? 396 LEU   A CG  1 
ATOM   2490 C  CD1 . LEU   A 1 396 ? -10.61742 -12.51415 -21.12314 1.000 14.87958 ? 396 LEU   A CD1 1 
ATOM   2491 C  CD2 . LEU   A 1 396 ? -9.19156  -14.33008 -20.14577 1.000 28.84311 ? 396 LEU   A CD2 1 
ATOM   2492 N  N   . ASP   A 1 397 ? -9.65702  -11.44231 -15.89802 1.000 24.04520 ? 397 ASP   A N   1 
ATOM   2493 C  CA  . ASP   A 1 397 ? -10.07143 -11.82525 -14.54855 1.000 20.14241 ? 397 ASP   A CA  1 
ATOM   2494 C  C   . ASP   A 1 397 ? -11.31127 -11.05147 -14.11976 1.000 17.79505 ? 397 ASP   A C   1 
ATOM   2495 O  O   . ASP   A 1 397 ? -12.29639 -11.63254 -13.64725 1.000 16.65794 ? 397 ASP   A O   1 
ATOM   2496 C  CB  . ASP   A 1 397 ? -8.94558  -11.56484 -13.54478 1.000 21.29046 ? 397 ASP   A CB  1 
ATOM   2497 C  CG  . ASP   A 1 397 ? -7.78865  -12.54866 -13.66115 1.000 31.04140 ? 397 ASP   A CG  1 
ATOM   2498 O  OD1 . ASP   A 1 397 ? -7.96063  -13.62290 -14.29173 1.000 21.80488 ? 397 ASP   A OD1 1 
ATOM   2499 O  OD2 . ASP   A 1 397 ? -6.71043  -12.23152 -13.08674 1.000 29.93720 ? 397 ASP   A OD2 1 
ATOM   2500 N  N   . THR   A 1 398 ? -11.26898 -9.72816  -14.26344 1.000 14.79190 ? 398 THR   A N   1 
ATOM   2501 C  CA  . THR   A 1 398 ? -12.35278 -8.91631  -13.73237 1.000 16.28432 ? 398 THR   A CA  1 
ATOM   2502 C  C   . THR   A 1 398 ? -13.63979 -9.19757  -14.48075 1.000 13.52614 ? 398 THR   A C   1 
ATOM   2503 O  O   . THR   A 1 398 ? -14.70190 -9.35726  -13.86578 1.000 15.94718 ? 398 THR   A O   1 
ATOM   2504 C  CB  . THR   A 1 398 ? -11.97222 -7.44453  -13.81314 1.000 13.14915 ? 398 THR   A CB  1 
ATOM   2505 O  OG1 . THR   A 1 398 ? -10.72035 -7.26792  -13.15348 1.000 21.13826 ? 398 THR   A OG1 1 
ATOM   2506 C  CG2 . THR   A 1 398 ? -13.02524 -6.56957  -13.14388 1.000 12.39379 ? 398 THR   A CG2 1 
ATOM   2507 N  N   . LEU   A 1 399 ? -13.54734 -9.27148  -15.81092 1.000 15.95546 ? 399 LEU   A N   1 
ATOM   2508 C  CA  . LEU   A 1 399 ? -14.66846 -9.68641  -16.64491 1.000 16.18735 ? 399 LEU   A CA  1 
ATOM   2509 C  C   . LEU   A 1 399 ? -15.32083 -10.95544 -16.10897 1.000 16.26666 ? 399 LEU   A C   1 
ATOM   2510 O  O   . LEU   A 1 399 ? -16.54381 -11.02920 -15.96127 1.000 15.97891 ? 399 LEU   A O   1 
ATOM   2511 C  CB  . LEU   A 1 399 ? -14.17947 -9.90484  -18.07998 1.000 12.24334 ? 399 LEU   A CB  1 
ATOM   2512 C  CG  . LEU   A 1 399 ? -15.27285 -10.24476 -19.09559 1.000 14.94531 ? 399 LEU   A CG  1 
ATOM   2513 C  CD1 . LEU   A 1 399 ? -16.40809 -9.22446  -19.02450 1.000 8.69985  ? 399 LEU   A CD1 1 
ATOM   2514 C  CD2 . LEU   A 1 399 ? -14.72929 -10.34334 -20.53475 1.000 9.50552  ? 399 LEU   A CD2 1 
ATOM   2515 N  N   . GLU   A 1 400 ? -14.51176 -11.96931 -15.82085 1.000 19.04148 ? 400 GLU   A N   1 
ATOM   2516 C  CA  . GLU   A 1 400 ? -15.05161 -13.23980 -15.35473 1.000 17.90565 ? 400 GLU   A CA  1 
ATOM   2517 C  C   . GLU   A 1 400 ? -15.69673 -13.08764 -13.98447 1.000 18.03491 ? 400 GLU   A C   1 
ATOM   2518 O  O   . GLU   A 1 400 ? -16.83410 -13.53048 -13.77858 1.000 19.87438 ? 400 GLU   A O   1 
ATOM   2519 C  CB  . GLU   A 1 400 ? -13.93878 -14.29869 -15.36525 1.000 18.04734 ? 400 GLU   A CB  1 
ATOM   2520 C  CG  . GLU   A 1 400 ? -13.65074 -14.76112 -16.80295 1.000 19.91917 ? 400 GLU   A CG  1 
ATOM   2521 C  CD  . GLU   A 1 400 ? -12.33475 -15.52841 -17.00681 1.000 23.91586 ? 400 GLU   A CD  1 
ATOM   2522 O  OE1 . GLU   A 1 400 ? -12.12161 -15.99447 -18.14640 1.000 25.98283 ? 400 GLU   A OE1 1 
ATOM   2523 O  OE2 . GLU   A 1 400 ? -11.52008 -15.67170 -16.06838 1.000 21.91002 ? 400 GLU   A OE2 1 
ATOM   2524 N  N   . ASP   A 1 401 ? -15.01315 -12.41332 -13.04712 1.000 15.92251 ? 401 ASP   A N   1 
ATOM   2525 C  CA  . ASP   A 1 401 ? -15.64387 -12.10210 -11.76283 1.000 19.63988 ? 401 ASP   A CA  1 
ATOM   2526 C  C   . ASP   A 1 401 ? -16.96744 -11.36595 -11.95708 1.000 21.43771 ? 401 ASP   A C   1 
ATOM   2527 O  O   . ASP   A 1 401 ? -17.97790 -11.70685 -11.33355 1.000 20.68302 ? 401 ASP   A O   1 
ATOM   2528 C  CB  . ASP   A 1 401 ? -14.69847 -11.27405 -10.88070 1.000 15.83935 ? 401 ASP   A CB  1 
ATOM   2529 C  CG  . ASP   A 1 401 ? -13.49555 -12.06925 -10.41007 1.000 19.18286 ? 401 ASP   A CG  1 
ATOM   2530 O  OD1 . ASP   A 1 401 ? -13.55717 -13.32451 -10.38320 1.000 21.75759 ? 401 ASP   A OD1 1 
ATOM   2531 O  OD2 . ASP   A 1 401 ? -12.48041 -11.43758 -10.06890 1.000 26.72608 ? 401 ASP   A OD2 1 
ATOM   2532 N  N   . ASN   A 1 402 ? -16.97936 -10.34347 -12.81669 1.000 18.21641 ? 402 ASN   A N   1 
ATOM   2533 C  CA  . ASN   A 1 402 ? -18.20912 -9.59121  -13.03433 1.000 17.01708 ? 402 ASN   A CA  1 
ATOM   2534 C  C   . ASN   A 1 402 ? -19.27698 -10.46591 -13.66057 1.000 21.06540 ? 402 ASN   A C   1 
ATOM   2535 O  O   . ASN   A 1 402 ? -20.47129 -10.31421 -13.36511 1.000 23.48803 ? 402 ASN   A O   1 
ATOM   2536 C  CB  . ASN   A 1 402 ? -17.94090 -8.37891  -13.91735 1.000 17.66607 ? 402 ASN   A CB  1 
ATOM   2537 C  CG  . ASN   A 1 402 ? -17.17695 -7.30469  -13.19896 1.000 18.64052 ? 402 ASN   A CG  1 
ATOM   2538 O  OD1 . ASN   A 1 402 ? -17.00713 -7.34948  -11.97613 1.000 20.32590 ? 402 ASN   A OD1 1 
ATOM   2539 N  ND2 . ASN   A 1 402 ? -16.72949 -6.31511  -13.94376 1.000 15.90395 ? 402 ASN   A ND2 1 
ATOM   2540 N  N   . ARG   A 1 403 ? -18.86452 -11.37685 -14.54540 1.000 23.37812 ? 403 ARG   A N   1 
ATOM   2541 C  CA  . ARG   A 1 403 ? -19.80470 -12.31122 -15.15132 1.000 21.81079 ? 403 ARG   A CA  1 
ATOM   2542 C  C   . ARG   A 1 403 ? -20.41169 -13.21883 -14.09661 1.000 25.44877 ? 403 ARG   A C   1 
ATOM   2543 O  O   . ARG   A 1 403 ? -21.63346 -13.41463 -14.05116 1.000 25.25623 ? 403 ARG   A O   1 
ATOM   2544 C  CB  . ARG   A 1 403 ? -19.09497 -13.13993 -16.21421 1.000 20.66081 ? 403 ARG   A CB  1 
ATOM   2545 C  CG  . ARG   A 1 403 ? -20.03587 -13.94851 -17.05414 1.000 24.12422 ? 403 ARG   A CG  1 
ATOM   2546 C  CD  . ARG   A 1 403 ? -20.23559 -15.35465 -16.55430 1.000 18.41230 ? 403 ARG   A CD  1 
ATOM   2547 N  NE  . ARG   A 1 403 ? -21.16501 -16.00731 -17.46715 1.000 25.24086 ? 403 ARG   A NE  1 
ATOM   2548 C  CZ  . ARG   A 1 403 ? -21.86659 -17.09768 -17.19205 1.000 21.49882 ? 403 ARG   A CZ  1 
ATOM   2549 N  NH1 . ARG   A 1 403 ? -21.76142 -17.68872 -16.01093 1.000 25.25896 ? 403 ARG   A NH1 1 
ATOM   2550 N  NH2 . ARG   A 1 403 ? -22.69044 -17.57970 -18.10180 1.000 20.38035 ? 403 ARG   A NH2 1 
ATOM   2551 N  N   . GLU   A 1 404 ? -19.55646 -13.79597 -13.25036 1.000 26.08150 ? 404 GLU   A N   1 
ATOM   2552 C  CA  . GLU   A 1 404 ? -20.02280 -14.56943 -12.10875 1.000 28.18742 ? 404 GLU   A CA  1 
ATOM   2553 C  C   . GLU   A 1 404 ? -21.05159 -13.78628 -11.31046 1.000 30.20609 ? 404 GLU   A C   1 
ATOM   2554 O  O   . GLU   A 1 404 ? -22.13249 -14.29609 -10.99635 1.000 30.50741 ? 404 GLU   A O   1 
ATOM   2555 C  CB  . GLU   A 1 404 ? -18.82875 -14.93561 -11.23190 1.000 31.60618 ? 404 GLU   A CB  1 
ATOM   2556 C  CG  . GLU   A 1 404 ? -18.84725 -16.33173 -10.66315 1.000 48.18207 ? 404 GLU   A CG  1 
ATOM   2557 C  CD  . GLU   A 1 404 ? -18.10222 -16.40984 -9.33843  1.000 56.97118 ? 404 GLU   A CD  1 
ATOM   2558 O  OE1 . GLU   A 1 404 ? -18.59054 -17.10496 -8.42135  1.000 64.56277 ? 404 GLU   A OE1 1 
ATOM   2559 O  OE2 . GLU   A 1 404 ? -17.03817 -15.76134 -9.20722  1.000 56.05629 ? 404 GLU   A OE2 1 
ATOM   2560 N  N   . TRP   A 1 405 ? -20.75762 -12.51607 -11.03244 1.000 27.19954 ? 405 TRP   A N   1 
ATOM   2561 C  CA  . TRP   A 1 405 ? -21.58233 -11.75230 -10.10738 1.000 23.43672 ? 405 TRP   A CA  1 
ATOM   2562 C  C   . TRP   A 1 405 ? -22.95911 -11.46798 -10.69699 1.000 27.70294 ? 405 TRP   A C   1 
ATOM   2563 O  O   . TRP   A 1 405 ? -23.98568 -11.65055 -10.02763 1.000 28.24822 ? 405 TRP   A O   1 
ATOM   2564 C  CB  . TRP   A 1 405 ? -20.86691 -10.45391 -9.72914  1.000 22.85562 ? 405 TRP   A CB  1 
ATOM   2565 C  CG  . TRP   A 1 405 ? -21.67139 -9.65802  -8.77956  1.000 21.77488 ? 405 TRP   A CG  1 
ATOM   2566 C  CD1 . TRP   A 1 405 ? -21.61522 -9.70243  -7.41071  1.000 21.76924 ? 405 TRP   A CD1 1 
ATOM   2567 C  CD2 . TRP   A 1 405 ? -22.67463 -8.70557  -9.10874  1.000 24.39463 ? 405 TRP   A CD2 1 
ATOM   2568 N  NE1 . TRP   A 1 405 ? -22.52224 -8.83891  -6.87812  1.000 19.14933 ? 405 TRP   A NE1 1 
ATOM   2569 C  CE2 . TRP   A 1 405 ? -23.18998 -8.21139  -7.89359  1.000 15.56791 ? 405 TRP   A CE2 1 
ATOM   2570 C  CE3 . TRP   A 1 405 ? -23.18745 -8.20940  -10.31820 1.000 21.27617 ? 405 TRP   A CE3 1 
ATOM   2571 C  CZ2 . TRP   A 1 405 ? -24.18824 -7.25736  -7.84881  1.000 17.71600 ? 405 TRP   A CZ2 1 
ATOM   2572 C  CZ3 . TRP   A 1 405 ? -24.18826 -7.26607  -10.26679 1.000 17.14104 ? 405 TRP   A CZ3 1 
ATOM   2573 C  CH2 . TRP   A 1 405 ? -24.67525 -6.79744  -9.04256  1.000 18.20480 ? 405 TRP   A CH2 1 
ATOM   2574 N  N   . TYR   A 1 406 ? -23.00292 -10.99884 -11.94500 1.000 26.67327 ? 406 TYR   A N   1 
ATOM   2575 C  CA  . TYR   A 1 406 ? -24.28829 -10.79835 -12.60565 1.000 26.62396 ? 406 TYR   A CA  1 
ATOM   2576 C  C   . TYR   A 1 406 ? -25.10971 -12.08033 -12.64953 1.000 29.17621 ? 406 TYR   A C   1 
ATOM   2577 O  O   . TYR   A 1 406 ? -26.34348 -12.02755 -12.57273 1.000 26.99407 ? 406 TYR   A O   1 
ATOM   2578 C  CB  . TYR   A 1 406 ? -24.07428 -10.25135 -14.01125 1.000 18.90879 ? 406 TYR   A CB  1 
ATOM   2579 C  CG  . TYR   A 1 406 ? -24.30443 -8.75869  -14.09365 1.000 23.13988 ? 406 TYR   A CG  1 
ATOM   2580 C  CD1 . TYR   A 1 406 ? -25.57953 -8.22321  -13.96047 1.000 16.98673 ? 406 TYR   A CD1 1 
ATOM   2581 C  CD2 . TYR   A 1 406 ? -23.24170 -7.88810  -14.27978 1.000 18.17846 ? 406 TYR   A CD2 1 
ATOM   2582 C  CE1 . TYR   A 1 406 ? -25.79176 -6.84397  -14.02503 1.000 17.99373 ? 406 TYR   A CE1 1 
ATOM   2583 C  CE2 . TYR   A 1 406 ? -23.43852 -6.51610  -14.34035 1.000 22.43251 ? 406 TYR   A CE2 1 
ATOM   2584 C  CZ  . TYR   A 1 406 ? -24.71252 -5.99723  -14.22712 1.000 23.04492 ? 406 TYR   A CZ  1 
ATOM   2585 O  OH  . TYR   A 1 406 ? -24.87089 -4.62670  -14.30709 1.000 23.67328 ? 406 TYR   A OH  1 
ATOM   2586 N  N   . GLN   A 1 407 ? -24.44581 -13.23222 -12.77464 1.000 28.39784 ? 407 GLN   A N   1 
ATOM   2587 C  CA  . GLN   A 1 407 ? -25.14715 -14.51089 -12.71941 1.000 35.13651 ? 407 GLN   A CA  1 
ATOM   2588 C  C   . GLN   A 1 407 ? -25.77634 -14.72052 -11.34964 1.000 32.09665 ? 407 GLN   A C   1 
ATOM   2589 O  O   . GLN   A 1 407 ? -26.95724 -15.06519 -11.24162 1.000 36.75159 ? 407 GLN   A O   1 
ATOM   2590 C  CB  . GLN   A 1 407 ? -24.17431 -15.65148 -13.04372 1.000 29.36849 ? 407 GLN   A CB  1 
ATOM   2591 C  CG  . GLN   A 1 407 ? -24.80887 -17.04940 -13.14260 1.000 32.49010 ? 407 GLN   A CG  1 
ATOM   2592 C  CD  . GLN   A 1 407 ? -25.60651 -17.25686 -14.41997 1.000 33.06066 ? 407 GLN   A CD  1 
ATOM   2593 O  OE1 . GLN   A 1 407 ? -25.26362 -16.72725 -15.47275 1.000 35.48096 ? 407 GLN   A OE1 1 
ATOM   2594 N  NE2 . GLN   A 1 407 ? -26.67760 -18.03184 -14.33119 1.000 44.68903 ? 407 GLN   A NE2 1 
ATOM   2595 N  N   . SER   A 1 408 ? -24.99548 -14.49242 -10.28819 1.000 31.17622 ? 408 SER   A N   1 
ATOM   2596 C  CA  . SER   A 1 408 ? -25.44061 -14.74700 -8.92141  1.000 33.06710 ? 408 SER   A CA  1 
ATOM   2597 C  C   . SER   A 1 408 ? -26.65670 -13.92605 -8.52408  1.000 33.09437 ? 408 SER   A C   1 
ATOM   2598 O  O   . SER   A 1 408 ? -27.35762 -14.30021 -7.57999  1.000 37.63505 ? 408 SER   A O   1 
ATOM   2599 C  CB  . SER   A 1 408 ? -24.30621 -14.46373 -7.94156  1.000 31.88050 ? 408 SER   A CB  1 
ATOM   2600 O  OG  . SER   A 1 408 ? -24.03732 -13.07367 -7.85393  1.000 34.64383 ? 408 SER   A OG  1 
ATOM   2601 N  N   . THR   A 1 409 ? -26.90865 -12.80729 -9.18749  1.000 35.69007 ? 409 THR   A N   1 
ATOM   2602 C  CA  . THR   A 1 409 ? -28.08270 -12.00256 -8.88442  1.000 44.51177 ? 409 THR   A CA  1 
ATOM   2603 C  C   . THR   A 1 409 ? -29.30758 -12.43332 -9.68082  1.000 50.63326 ? 409 THR   A C   1 
ATOM   2604 O  O   . THR   A 1 409 ? -30.34709 -11.76561 -9.60307  1.000 50.07909 ? 409 THR   A O   1 
ATOM   2605 C  CB  . THR   A 1 409 ? -27.79779 -10.50982 -9.13779  1.000 39.95803 ? 409 THR   A CB  1 
ATOM   2606 O  OG1 . THR   A 1 409 ? -27.87616 -10.22772 -10.54124 1.000 39.92297 ? 409 THR   A OG1 1 
ATOM   2607 C  CG2 . THR   A 1 409 ? -26.40777 -10.12392 -8.62018  1.000 35.57506 ? 409 THR   A CG2 1 
ATOM   2608 N  N   . ILE   A 1 410 ? -29.21504 -13.52343 -10.43806 1.000 46.72844 ? 410 ILE   A N   1 
ATOM   2609 C  CA  . ILE   A 1 410 ? -30.33446 -13.96954 -11.26282 1.000 55.08166 ? 410 ILE   A CA  1 
ATOM   2610 C  C   . ILE   A 1 410 ? -31.22894 -14.84071 -10.38790 1.000 55.60962 ? 410 ILE   A C   1 
ATOM   2611 O  O   . ILE   A 1 410 ? -30.73719 -15.80660 -9.77819  1.000 53.55994 ? 410 ILE   A O   1 
ATOM   2612 C  CB  . ILE   A 1 410 ? -29.84613 -14.70031 -12.52660 1.000 53.66627 ? 410 ILE   A CB  1 
ATOM   2613 C  CG1 . ILE   A 1 410 ? -29.02348 -13.74647 -13.40463 1.000 43.05343 ? 410 ILE   A CG1 1 
ATOM   2614 C  CG2 . ILE   A 1 410 ? -31.02295 -15.25940 -13.32771 1.000 46.30710 ? 410 ILE   A CG2 1 
ATOM   2615 C  CD1 . ILE   A 1 410 ? -28.63210 -14.32856 -14.74893 1.000 40.11087 ? 410 ILE   A CD1 1 
ATOM   2616 N  N   . PRO   A 1 411 ? -32.54161 -14.51965 -10.27645 1.000 59.28011 ? 411 PRO   A N   1 
ATOM   2617 C  CA  . PRO   A 1 411 ? -33.55925 -15.10794 -9.39036  1.000 64.38441 ? 411 PRO   A CA  1 
ATOM   2618 C  C   . PRO   A 1 411 ? -33.40921 -16.60239 -9.11519  1.000 57.64514 ? 411 PRO   A C   1 
ATOM   2619 O  O   . PRO   A 1 411 ? -33.42793 -16.97291 -7.93909  1.000 62.98032 ? 411 PRO   A O   1 
ATOM   2620 C  CB  . PRO   A 1 411 ? -34.86651 -14.82709 -10.14200 1.000 60.02309 ? 411 PRO   A CB  1 
ATOM   2621 C  CG  . PRO   A 1 411 ? -34.59007 -13.59052 -10.96219 1.000 53.50776 ? 411 PRO   A CG  1 
ATOM   2622 C  CD  . PRO   A 1 411 ? -33.09307 -13.36157 -11.00541 1.000 59.60413 ? 411 PRO   A CD  1 
ATOM   2623 N  N   . VAL   B 1 91  ? -43.31454 10.83250  -84.38838 1.000 66.50353 ? 91  VAL   B N   1 
ATOM   2624 C  CA  . VAL   B 1 91  ? -42.51082 11.89674  -83.80300 1.000 73.53456 ? 91  VAL   B CA  1 
ATOM   2625 C  C   . VAL   B 1 91  ? -41.36726 11.29203  -82.99868 1.000 84.33153 ? 91  VAL   B C   1 
ATOM   2626 O  O   . VAL   B 1 91  ? -40.66918 10.38155  -83.46008 1.000 82.71835 ? 91  VAL   B O   1 
ATOM   2627 C  CB  . VAL   B 1 91  ? -43.37295 12.81594  -82.91467 1.000 72.48327 ? 91  VAL   B CB  1 
ATOM   2628 C  CG1 . VAL   B 1 91  ? -44.02622 13.90772  -83.74563 1.000 64.89202 ? 91  VAL   B CG1 1 
ATOM   2629 C  CG2 . VAL   B 1 91  ? -44.42574 11.99875  -82.17969 1.000 64.23482 ? 91  VAL   B CG2 1 
ATOM   2630 N  N   . LEU   B 1 92  ? -41.18446 11.82657  -81.79021 1.000 83.12650 ? 92  LEU   B N   1 
ATOM   2631 C  CA  . LEU   B 1 92  ? -40.44915 11.16892  -80.71616 1.000 78.72961 ? 92  LEU   B CA  1 
ATOM   2632 C  C   . LEU   B 1 92  ? -40.79171 9.68492   -80.68581 1.000 78.03504 ? 92  LEU   B C   1 
ATOM   2633 O  O   . LEU   B 1 92  ? -39.92393 8.83398   -80.46236 1.000 75.75763 ? 92  LEU   B O   1 
ATOM   2634 C  CB  . LEU   B 1 92  ? -40.80620 11.82869  -79.37995 1.000 80.17528 ? 92  LEU   B CB  1 
ATOM   2635 C  CG  . LEU   B 1 92  ? -40.15362 11.41988  -78.06019 1.000 78.47744 ? 92  LEU   B CG  1 
ATOM   2636 C  CD1 . LEU   B 1 92  ? -38.84944 12.16082  -77.84876 1.000 76.85992 ? 92  LEU   B CD1 1 
ATOM   2637 C  CD2 . LEU   B 1 92  ? -41.10693 11.66911  -76.90107 1.000 76.54963 ? 92  LEU   B CD2 1 
ATOM   2638 N  N   . ALA   B 1 93  ? -42.06912 9.38262   -80.93631 1.000 78.06886 ? 93  ALA   B N   1 
ATOM   2639 C  CA  . ALA   B 1 93  ? -42.56407 8.01433   -80.86876 1.000 74.27138 ? 93  ALA   B CA  1 
ATOM   2640 C  C   . ALA   B 1 93  ? -41.80766 7.08071   -81.80310 1.000 72.78761 ? 93  ALA   B C   1 
ATOM   2641 O  O   . ALA   B 1 93  ? -41.57811 5.91369   -81.46692 1.000 72.00230 ? 93  ALA   B O   1 
ATOM   2642 C  CB  . ALA   B 1 93  ? -44.05521 7.99277   -81.20006 1.000 78.89637 ? 93  ALA   B CB  1 
ATOM   2643 N  N   . LYS   B 1 94  ? -41.41226 7.57129   -82.98063 1.000 75.59143 ? 94  LYS   B N   1 
ATOM   2644 C  CA  . LYS   B 1 94  ? -40.91133 6.67232   -84.01819 1.000 77.47013 ? 94  LYS   B CA  1 
ATOM   2645 C  C   . LYS   B 1 94  ? -39.68171 5.90653   -83.54333 1.000 75.56096 ? 94  LYS   B C   1 
ATOM   2646 O  O   . LYS   B 1 94  ? -39.60179 4.68104   -83.69217 1.000 68.84497 ? 94  LYS   B O   1 
ATOM   2647 C  CB  . LYS   B 1 94  ? -40.59852 7.45246   -85.29907 1.000 82.42464 ? 94  LYS   B CB  1 
ATOM   2648 C  CG  . LYS   B 1 94  ? -40.88453 6.67486   -86.60352 1.000 82.42868 ? 94  LYS   B CG  1 
ATOM   2649 C  CD  . LYS   B 1 94  ? -40.02116 5.40944   -86.75988 1.000 78.45729 ? 94  LYS   B CD  1 
ATOM   2650 C  CE  . LYS   B 1 94  ? -40.43779 4.58566   -87.97553 1.000 72.50302 ? 94  LYS   B CE  1 
ATOM   2651 N  NZ  . LYS   B 1 94  ? -39.60293 3.36104   -88.17368 1.000 64.56054 ? 94  LYS   B NZ  1 
ATOM   2652 N  N   . GLU   B 1 95  ? -38.70379 6.60910   -82.98100 1.000 74.00154 ? 95  GLU   B N   1 
ATOM   2653 C  CA  . GLU   B 1 95  ? -37.50432 5.91716   -82.53251 1.000 71.52506 ? 95  GLU   B CA  1 
ATOM   2654 C  C   . GLU   B 1 95  ? -37.67829 5.27647   -81.16185 1.000 68.85206 ? 95  GLU   B C   1 
ATOM   2655 O  O   . GLU   B 1 95  ? -36.96940 4.31385   -80.84603 1.000 64.24516 ? 95  GLU   B O   1 
ATOM   2656 C  CB  . GLU   B 1 95  ? -36.30498 6.87220   -82.52914 1.000 71.34867 ? 95  GLU   B CB  1 
ATOM   2657 C  CG  . GLU   B 1 95  ? -35.95549 7.44309   -83.90820 1.000 70.18725 ? 95  GLU   B CG  1 
ATOM   2658 C  CD  . GLU   B 1 95  ? -35.12321 6.49215   -84.75727 1.000 70.86432 ? 95  GLU   B CD  1 
ATOM   2659 O  OE1 . GLU   B 1 95  ? -35.05817 6.69342   -85.98965 1.000 72.41204 ? 95  GLU   B OE1 1 
ATOM   2660 O  OE2 . GLU   B 1 95  ? -34.53600 5.54321   -84.19669 1.000 72.48569 ? 95  GLU   B OE2 1 
ATOM   2661 N  N   . LEU   B 1 96  ? -38.62158 5.76302   -80.35126 1.000 68.48671 ? 96  LEU   B N   1 
ATOM   2662 C  CA  . LEU   B 1 96  ? -38.86906 5.14086   -79.05265 1.000 64.11294 ? 96  LEU   B CA  1 
ATOM   2663 C  C   . LEU   B 1 96  ? -39.22407 3.67000   -79.19814 1.000 63.75912 ? 96  LEU   B C   1 
ATOM   2664 O  O   . LEU   B 1 96  ? -38.66407 2.81493   -78.50222 1.000 64.41812 ? 96  LEU   B O   1 
ATOM   2665 C  CB  . LEU   B 1 96  ? -39.97626 5.87982   -78.31063 1.000 58.07205 ? 96  LEU   B CB  1 
ATOM   2666 C  CG  . LEU   B 1 96  ? -39.48591 7.11959   -77.58236 1.000 58.20931 ? 96  LEU   B CG  1 
ATOM   2667 C  CD1 . LEU   B 1 96  ? -40.65932 7.95952   -77.11635 1.000 51.86114 ? 96  LEU   B CD1 1 
ATOM   2668 C  CD2 . LEU   B 1 96  ? -38.59748 6.69494   -76.41213 1.000 51.92877 ? 96  LEU   B CD2 1 
ATOM   2669 N  N   . GLU   B 1 97  ? -40.12543 3.34761   -80.13002 1.000 63.20083 ? 97  GLU   B N   1 
ATOM   2670 C  CA  . GLU   B 1 97  ? -40.55352 1.96468   -80.31764 1.000 64.14060 ? 97  GLU   B CA  1 
ATOM   2671 C  C   . GLU   B 1 97  ? -39.37764 1.07215   -80.69848 1.000 58.57608 ? 97  GLU   B C   1 
ATOM   2672 O  O   . GLU   B 1 97  ? -39.55069 -0.12560  -80.92980 1.000 60.32668 ? 97  GLU   B O   1 
ATOM   2673 C  CB  . GLU   B 1 97  ? -41.67389 1.87491   -81.36135 1.000 64.01397 ? 97  GLU   B CB  1 
ATOM   2674 C  CG  . GLU   B 1 97  ? -41.38046 2.60535   -82.65198 1.000 68.94749 ? 97  GLU   B CG  1 
ATOM   2675 C  CD  . GLU   B 1 97  ? -42.55912 2.63310   -83.61809 1.000 72.98081 ? 97  GLU   B CD  1 
ATOM   2676 O  OE1 . GLU   B 1 97  ? -43.17670 1.56711   -83.84594 1.000 71.81688 ? 97  GLU   B OE1 1 
ATOM   2677 O  OE2 . GLU   B 1 97  ? -42.86880 3.72488   -84.14701 1.000 66.02569 ? 97  GLU   B OE2 1 
ATOM   2678 N  N   . ASP   B 1 98  ? -38.17902 1.63988   -80.75090 1.000 62.49735 ? 98  ASP   B N   1 
ATOM   2679 C  CA  . ASP   B 1 98  ? -36.95033 0.86207   -80.82162 1.000 63.36076 ? 98  ASP   B CA  1 
ATOM   2680 C  C   . ASP   B 1 98  ? -36.37502 0.49862   -79.45436 1.000 61.71191 ? 98  ASP   B C   1 
ATOM   2681 O  O   . ASP   B 1 98  ? -35.29465 -0.10116  -79.39502 1.000 52.63666 ? 98  ASP   B O   1 
ATOM   2682 C  CB  . ASP   B 1 98  ? -35.87811 1.62542   -81.59965 1.000 63.83285 ? 98  ASP   B CB  1 
ATOM   2683 C  CG  . ASP   B 1 98  ? -36.17132 1.68544   -83.07733 1.000 73.55546 ? 98  ASP   B CG  1 
ATOM   2684 O  OD1 . ASP   B 1 98  ? -37.06727 0.93015   -83.52265 1.000 78.59025 ? 98  ASP   B OD1 1 
ATOM   2685 O  OD2 . ASP   B 1 98  ? -35.49783 2.44682   -83.79782 1.000 74.87146 ? 98  ASP   B OD2 1 
ATOM   2686 N  N   . VAL   B 1 99  ? -37.07134 0.82882   -78.36501 1.000 62.12414 ? 99  VAL   B N   1 
ATOM   2687 C  CA  . VAL   B 1 99  ? -36.54490 0.75912   -77.00176 1.000 54.03406 ? 99  VAL   B CA  1 
ATOM   2688 C  C   . VAL   B 1 99  ? -36.05034 -0.63154  -76.61939 1.000 52.14405 ? 99  VAL   B C   1 
ATOM   2689 O  O   . VAL   B 1 99  ? -35.38231 -0.79213  -75.59375 1.000 54.05403 ? 99  VAL   B O   1 
ATOM   2690 C  CB  . VAL   B 1 99  ? -37.60526 1.23632   -75.99048 1.000 60.72189 ? 99  VAL   B CB  1 
ATOM   2691 C  CG1 . VAL   B 1 99  ? -38.66506 0.15770   -75.75732 1.000 64.02728 ? 99  VAL   B CG1 1 
ATOM   2692 C  CG2 . VAL   B 1 99  ? -36.95569 1.66399   -74.67798 1.000 65.86142 ? 99  VAL   B CG2 1 
ATOM   2693 N  N   . ASN   B 1 100 ? -36.37404 -1.64818  -77.41552 1.000 51.40579 ? 100 ASN   B N   1 
ATOM   2694 C  CA  . ASN   B 1 100 ? -35.91761 -3.00013  -77.10718 1.000 55.00559 ? 100 ASN   B CA  1 
ATOM   2695 C  C   . ASN   B 1 100 ? -34.51369 -3.29519  -77.62565 1.000 49.32999 ? 100 ASN   B C   1 
ATOM   2696 O  O   . ASN   B 1 100 ? -34.03426 -4.42045  -77.44387 1.000 45.79518 ? 100 ASN   B O   1 
ATOM   2697 C  CB  . ASN   B 1 100 ? -36.88873 -4.04620  -77.68281 1.000 63.97825 ? 100 ASN   B CB  1 
ATOM   2698 C  CG  . ASN   B 1 100 ? -38.20693 -4.13683  -76.91358 1.000 61.36008 ? 100 ASN   B CG  1 
ATOM   2699 O  OD1 . ASN   B 1 100 ? -39.08452 -3.27622  -77.03919 1.000 57.63354 ? 100 ASN   B OD1 1 
ATOM   2700 N  ND2 . ASN   B 1 100 ? -38.35945 -5.20450  -76.13872 1.000 56.40265 ? 100 ASN   B ND2 1 
ATOM   2701 N  N   . LYS   B 1 101 ? -33.83913 -2.33502  -78.25546 1.000 47.16372 ? 101 LYS   B N   1 
ATOM   2702 C  CA  . LYS   B 1 101 ? -32.64723 -2.63810  -79.03652 1.000 48.85472 ? 101 LYS   B CA  1 
ATOM   2703 C  C   . LYS   B 1 101 ? -31.35208 -2.02526  -78.52039 1.000 39.48151 ? 101 LYS   B C   1 
ATOM   2704 O  O   . LYS   B 1 101 ? -31.31697 -0.92194  -77.97169 1.000 37.41712 ? 101 LYS   B O   1 
ATOM   2705 C  CB  . LYS   B 1 101 ? -32.82578 -2.21769  -80.48671 1.000 60.66565 ? 101 LYS   B CB  1 
ATOM   2706 C  CG  . LYS   B 1 101 ? -33.67787 -3.18512  -81.24015 1.000 63.34758 ? 101 LYS   B CG  1 
ATOM   2707 C  CD  . LYS   B 1 101 ? -34.19129 -2.55395  -82.50714 1.000 71.96388 ? 101 LYS   B CD  1 
ATOM   2708 C  CE  . LYS   B 1 101 ? -35.50791 -1.86640  -82.33031 1.000 76.09448 ? 101 LYS   B CE  1 
ATOM   2709 N  NZ  . LYS   B 1 101 ? -36.08793 -1.48353  -83.65410 1.000 76.50145 ? 101 LYS   B NZ  1 
ATOM   2710 N  N   . TRP   B 1 102 ? -30.27614 -2.75787  -78.78649 1.000 30.43620 ? 102 TRP   B N   1 
ATOM   2711 C  CA  . TRP   B 1 102 ? -28.90903 -2.37170  -78.45895 1.000 47.25251 ? 102 TRP   B CA  1 
ATOM   2712 C  C   . TRP   B 1 102 ? -28.40426 -1.40726  -79.52514 1.000 48.40972 ? 102 TRP   B C   1 
ATOM   2713 O  O   . TRP   B 1 102 ? -27.68972 -1.77599  -80.45864 1.000 46.97273 ? 102 TRP   B O   1 
ATOM   2714 C  CB  . TRP   B 1 102 ? -28.03196 -3.61301  -78.38623 1.000 54.60900 ? 102 TRP   B CB  1 
ATOM   2715 C  CG  . TRP   B 1 102 ? -26.72433 -3.45271  -77.66575 1.000 49.87721 ? 102 TRP   B CG  1 
ATOM   2716 C  CD1 . TRP   B 1 102 ? -25.47417 -3.41623  -78.22005 1.000 41.93786 ? 102 TRP   B CD1 1 
ATOM   2717 C  CD2 . TRP   B 1 102 ? -26.53937 -3.35359  -76.25210 1.000 45.74912 ? 102 TRP   B CD2 1 
ATOM   2718 N  NE1 . TRP   B 1 102 ? -24.52446 -3.28693  -77.23695 1.000 39.38519 ? 102 TRP   B NE1 1 
ATOM   2719 C  CE2 . TRP   B 1 102 ? -25.15121 -3.24554  -76.01910 1.000 43.14418 ? 102 TRP   B CE2 1 
ATOM   2720 C  CE3 . TRP   B 1 102 ? -27.41393 -3.33098  -75.16039 1.000 40.60891 ? 102 TRP   B CE3 1 
ATOM   2721 C  CZ2 . TRP   B 1 102 ? -24.61849 -3.12179  -74.74066 1.000 40.51863 ? 102 TRP   B CZ2 1 
ATOM   2722 C  CZ3 . TRP   B 1 102 ? -26.88673 -3.20852  -73.89493 1.000 42.85687 ? 102 TRP   B CZ3 1 
ATOM   2723 C  CH2 . TRP   B 1 102 ? -25.49824 -3.10912  -73.69276 1.000 41.73777 ? 102 TRP   B CH2 1 
ATOM   2724 N  N   . GLY   B 1 103 ? -28.77935 -0.14427  -79.38165 1.000 41.87804 ? 103 GLY   B N   1 
ATOM   2725 C  CA  . GLY   B 1 103 ? -28.33494 0.84857   -80.33609 1.000 39.57398 ? 103 GLY   B CA  1 
ATOM   2726 C  C   . GLY   B 1 103 ? -29.33758 1.97054   -80.44938 1.000 45.31149 ? 103 GLY   B C   1 
ATOM   2727 O  O   . GLY   B 1 103 ? -29.42551 2.64456   -81.47989 1.000 49.16866 ? 103 GLY   B O   1 
ATOM   2728 N  N   . LEU   B 1 104 ? -30.10915 2.16439   -79.38427 1.000 40.75323 ? 104 LEU   B N   1 
ATOM   2729 C  CA  . LEU   B 1 104 ? -31.11992 3.20377   -79.38013 1.000 44.73907 ? 104 LEU   B CA  1 
ATOM   2730 C  C   . LEU   B 1 104 ? -30.48810 4.55575   -79.68959 1.000 51.55894 ? 104 LEU   B C   1 
ATOM   2731 O  O   . LEU   B 1 104 ? -29.34436 4.84129   -79.31764 1.000 53.26105 ? 104 LEU   B O   1 
ATOM   2732 C  CB  . LEU   B 1 104 ? -31.83781 3.23462   -78.03107 1.000 39.03190 ? 104 LEU   B CB  1 
ATOM   2733 C  CG  . LEU   B 1 104 ? -32.97980 4.24752   -77.93334 1.000 51.39090 ? 104 LEU   B CG  1 
ATOM   2734 C  CD1 . LEU   B 1 104 ? -34.16734 3.83882   -78.81354 1.000 56.86643 ? 104 LEU   B CD1 1 
ATOM   2735 C  CD2 . LEU   B 1 104 ? -33.41012 4.44361   -76.48340 1.000 44.44092 ? 104 LEU   B CD2 1 
ATOM   2736 N  N   . HIS   B 1 105 ? -31.24220 5.38699   -80.39839 1.000 46.73181 ? 105 HIS   B N   1 
ATOM   2737 C  CA  . HIS   B 1 105 ? -30.77576 6.71484   -80.76916 1.000 45.07222 ? 105 HIS   B CA  1 
ATOM   2738 C  C   . HIS   B 1 105 ? -31.10233 7.68384   -79.62991 1.000 47.39262 ? 105 HIS   B C   1 
ATOM   2739 O  O   . HIS   B 1 105 ? -31.97354 8.55131   -79.71150 1.000 48.55048 ? 105 HIS   B O   1 
ATOM   2740 C  CB  . HIS   B 1 105 ? -31.38545 7.12131   -82.10405 1.000 53.53453 ? 105 HIS   B CB  1 
ATOM   2741 C  CG  . HIS   B 1 105 ? -30.95072 6.25984   -83.25559 1.000 56.22661 ? 105 HIS   B CG  1 
ATOM   2742 N  ND1 . HIS   B 1 105 ? -31.26655 6.54990   -84.56690 1.000 62.80344 ? 105 HIS   B ND1 1 
ATOM   2743 C  CD2 . HIS   B 1 105 ? -30.22451 5.11412   -83.29038 1.000 57.32709 ? 105 HIS   B CD2 1 
ATOM   2744 C  CE1 . HIS   B 1 105 ? -30.75408 5.62117   -85.35746 1.000 64.59957 ? 105 HIS   B CE1 1 
ATOM   2745 N  NE2 . HIS   B 1 105 ? -30.11396 4.74003   -84.60854 1.000 53.03172 ? 105 HIS   B NE2 1 
ATOM   2746 N  N   . VAL   B 1 106 ? -30.36181 7.50913   -78.53240 1.000 44.82443 ? 106 VAL   B N   1 
ATOM   2747 C  CA  . VAL   B 1 106 ? -30.66612 8.24556   -77.30987 1.000 36.64060 ? 106 VAL   B CA  1 
ATOM   2748 C  C   . VAL   B 1 106 ? -30.35658 9.72669   -77.47295 1.000 40.62310 ? 106 VAL   B C   1 
ATOM   2749 O  O   . VAL   B 1 106 ? -31.05938 10.58666  -76.91448 1.000 40.08664 ? 106 VAL   B O   1 
ATOM   2750 C  CB  . VAL   B 1 106 ? -29.91179 7.62247   -76.11526 1.000 39.96190 ? 106 VAL   B CB  1 
ATOM   2751 C  CG1 . VAL   B 1 106 ? -28.40175 7.70851   -76.30561 1.000 26.62290 ? 106 VAL   B CG1 1 
ATOM   2752 C  CG2 . VAL   B 1 106 ? -30.33780 8.27712   -74.81816 1.000 27.80599 ? 106 VAL   B CG2 1 
ATOM   2753 N  N   . PHE   B 1 107 ? -29.32439 10.05863  -78.24897 1.000 37.02739 ? 107 PHE   B N   1 
ATOM   2754 C  CA  . PHE   B 1 107 ? -29.03300 11.46116  -78.50838 1.000 36.46864 ? 107 PHE   B CA  1 
ATOM   2755 C  C   . PHE   B 1 107 ? -30.14806 12.10011  -79.32559 1.000 43.28924 ? 107 PHE   B C   1 
ATOM   2756 O  O   . PHE   B 1 107 ? -30.55085 13.23996  -79.06598 1.000 43.50978 ? 107 PHE   B O   1 
ATOM   2757 C  CB  . PHE   B 1 107 ? -27.67582 11.57525  -79.20062 1.000 31.88228 ? 107 PHE   B CB  1 
ATOM   2758 C  CG  . PHE   B 1 107 ? -26.53258 11.12292  -78.33816 1.000 29.32093 ? 107 PHE   B CG  1 
ATOM   2759 C  CD1 . PHE   B 1 107 ? -26.18171 11.84416  -77.20647 1.000 27.77313 ? 107 PHE   B CD1 1 
ATOM   2760 C  CD2 . PHE   B 1 107 ? -25.82989 9.97084   -78.63754 1.000 29.97066 ? 107 PHE   B CD2 1 
ATOM   2761 C  CE1 . PHE   B 1 107 ? -25.14137 11.43193  -76.39320 1.000 31.76440 ? 107 PHE   B CE1 1 
ATOM   2762 C  CE2 . PHE   B 1 107 ? -24.78441 9.55433   -77.84114 1.000 31.25178 ? 107 PHE   B CE2 1 
ATOM   2763 C  CZ  . PHE   B 1 107 ? -24.43761 10.28011  -76.71310 1.000 28.11594 ? 107 PHE   B CZ  1 
ATOM   2764 N  N   . ARG   B 1 108 ? -30.66213 11.36816  -80.30939 1.000 47.25396 ? 108 ARG   B N   1 
ATOM   2765 C  CA  . ARG   B 1 108 ? -31.89629 11.74643  -80.98152 1.000 48.00096 ? 108 ARG   B CA  1 
ATOM   2766 C  C   . ARG   B 1 108 ? -32.98893 12.06667  -79.97069 1.000 48.85815 ? 108 ARG   B C   1 
ATOM   2767 O  O   . ARG   B 1 108 ? -33.49904 13.19216  -79.90538 1.000 45.14813 ? 108 ARG   B O   1 
ATOM   2768 C  CB  . ARG   B 1 108 ? -32.32294 10.58877  -81.87540 1.000 53.62515 ? 108 ARG   B CB  1 
ATOM   2769 C  CG  . ARG   B 1 108 ? -31.37583 10.31025  -83.02532 1.000 56.63458 ? 108 ARG   B CG  1 
ATOM   2770 C  CD  . ARG   B 1 108 ? -31.73897 11.11631  -84.21174 1.000 63.71305 ? 108 ARG   B CD  1 
ATOM   2771 N  NE  . ARG   B 1 108 ? -32.98436 10.60114  -84.77744 1.000 68.48382 ? 108 ARG   B NE  1 
ATOM   2772 C  CZ  . ARG   B 1 108 ? -33.07010 9.91769   -85.91171 1.000 69.03797 ? 108 ARG   B CZ  1 
ATOM   2773 N  NH1 . ARG   B 1 108 ? -31.97010 9.66151   -86.62394 1.000 64.82886 ? 108 ARG   B NH1 1 
ATOM   2774 N  NH2 . ARG   B 1 108 ? -34.26316 9.50908   -86.32940 1.000 70.80887 ? 108 ARG   B NH2 1 
ATOM   2775 N  N   . ILE   B 1 109 ? -33.33409 11.06924  -79.15103 1.000 47.37208 ? 109 ILE   B N   1 
ATOM   2776 C  CA  . ILE   B 1 109 ? -34.44774 11.18939  -78.21737 1.000 40.35016 ? 109 ILE   B CA  1 
ATOM   2777 C  C   . ILE   B 1 109 ? -34.23111 12.35362  -77.26550 1.000 47.42509 ? 109 ILE   B C   1 
ATOM   2778 O  O   . ILE   B 1 109 ? -35.17807 13.07232  -76.91966 1.000 45.82002 ? 109 ILE   B O   1 
ATOM   2779 C  CB  . ILE   B 1 109 ? -34.64302 9.86175   -77.46894 1.000 47.58740 ? 109 ILE   B CB  1 
ATOM   2780 C  CG1 . ILE   B 1 109 ? -35.03296 8.77387   -78.47231 1.000 42.64069 ? 109 ILE   B CG1 1 
ATOM   2781 C  CG2 . ILE   B 1 109 ? -35.69178 10.02697  -76.38830 1.000 41.46195 ? 109 ILE   B CG2 1 
ATOM   2782 C  CD1 . ILE   B 1 109 ? -34.46623 7.43983   -78.17446 1.000 41.76718 ? 109 ILE   B CD1 1 
ATOM   2783 N  N   . ALA   B 1 110 ? -32.98110 12.57664  -76.84410 1.000 46.75785 ? 110 ALA   B N   1 
ATOM   2784 C  CA  . ALA   B 1 110 ? -32.70206 13.70407  -75.96175 1.000 40.46263 ? 110 ALA   B CA  1 
ATOM   2785 C  C   . ALA   B 1 110 ? -33.03459 15.02079  -76.64752 1.000 48.73315 ? 110 ALA   B C   1 
ATOM   2786 O  O   . ALA   B 1 110 ? -33.60929 15.92538  -76.02712 1.000 45.85424 ? 110 ALA   B O   1 
ATOM   2787 C  CB  . ALA   B 1 110 ? -31.24187 13.67703  -75.50727 1.000 35.56754 ? 110 ALA   B CB  1 
ATOM   2788 N  N   . GLU   B 1 111 ? -32.69164 15.13995  -77.93408 1.000 50.51456 ? 111 GLU   B N   1 
ATOM   2789 C  CA  . GLU   B 1 111 ? -33.10952 16.30195  -78.71563 1.000 58.25141 ? 111 GLU   B CA  1 
ATOM   2790 C  C   . GLU   B 1 111 ? -34.63345 16.36570  -78.82770 1.000 53.34243 ? 111 GLU   B C   1 
ATOM   2791 O  O   . GLU   B 1 111 ? -35.24965 17.39204  -78.51157 1.000 40.08570 ? 111 GLU   B O   1 
ATOM   2792 C  CB  . GLU   B 1 111 ? -32.46380 16.26044  -80.10742 1.000 56.48365 ? 111 GLU   B CB  1 
ATOM   2793 C  CG  . GLU   B 1 111 ? -30.92869 16.28441  -80.12739 1.000 62.92263 ? 111 GLU   B CG  1 
ATOM   2794 C  CD  . GLU   B 1 111 ? -30.34313 15.95241  -81.50581 1.000 72.94478 ? 111 GLU   B CD  1 
ATOM   2795 O  OE1 . GLU   B 1 111 ? -31.00825 15.23255  -82.28653 1.000 73.36677 ? 111 GLU   B OE1 1 
ATOM   2796 O  OE2 . GLU   B 1 111 ? -29.21825 16.41210  -81.81139 1.000 73.95735 ? 111 GLU   B OE2 1 
ATOM   2797 N  N   . LEU   B 1 112 ? -35.26016 15.25753  -79.24896 1.000 45.95700 ? 112 LEU   B N   1 
ATOM   2798 C  CA  . LEU   B 1 112 ? -36.69858 15.24404  -79.50554 1.000 48.20946 ? 112 LEU   B CA  1 
ATOM   2799 C  C   . LEU   B 1 112 ? -37.54089 15.33136  -78.23880 1.000 53.58863 ? 112 LEU   B C   1 
ATOM   2800 O  O   . LEU   B 1 112 ? -38.70109 15.74741  -78.31830 1.000 58.44688 ? 112 LEU   B O   1 
ATOM   2801 C  CB  . LEU   B 1 112 ? -37.08680 13.98042  -80.27716 1.000 57.48387 ? 112 LEU   B CB  1 
ATOM   2802 C  CG  . LEU   B 1 112 ? -36.25065 13.66753  -81.52136 1.000 45.70897 ? 112 LEU   B CG  1 
ATOM   2803 C  CD1 . LEU   B 1 112 ? -36.22685 12.17287  -81.79130 1.000 50.23446 ? 112 LEU   B CD1 1 
ATOM   2804 C  CD2 . LEU   B 1 112 ? -36.78082 14.41573  -82.72689 1.000 49.79228 ? 112 LEU   B CD2 1 
ATOM   2805 N  N   . SER   B 1 113 ? -37.00671 14.93464  -77.08373 1.000 53.56919 ? 113 SER   B N   1 
ATOM   2806 C  CA  . SER   B 1 113 ? -37.76144 14.96932  -75.83624 1.000 49.24633 ? 113 SER   B CA  1 
ATOM   2807 C  C   . SER   B 1 113 ? -37.64064 16.29213  -75.10455 1.000 48.27069 ? 113 SER   B C   1 
ATOM   2808 O  O   . SER   B 1 113 ? -38.24428 16.44394  -74.03943 1.000 52.51225 ? 113 SER   B O   1 
ATOM   2809 C  CB  . SER   B 1 113 ? -37.30312 13.85561  -74.89414 1.000 51.00368 ? 113 SER   B CB  1 
ATOM   2810 O  OG  . SER   B 1 113 ? -36.02908 14.17464  -74.35650 1.000 47.99207 ? 113 SER   B OG  1 
ATOM   2811 N  N   . GLY   B 1 114 ? -36.87068 17.23890  -75.63011 1.000 45.00126 ? 114 GLY   B N   1 
ATOM   2812 C  CA  . GLY   B 1 114 ? -36.62770 18.47685  -74.91708 1.000 49.69157 ? 114 GLY   B CA  1 
ATOM   2813 C  C   . GLY   B 1 114 ? -35.73617 18.30462  -73.70207 1.000 41.79769 ? 114 GLY   B C   1 
ATOM   2814 O  O   . GLY   B 1 114 ? -36.04371 18.81438  -72.62050 1.000 48.21671 ? 114 GLY   B O   1 
ATOM   2815 N  N   . ASN   B 1 115 ? -34.61794 17.60130  -73.87667 1.000 41.42905 ? 115 ASN   B N   1 
ATOM   2816 C  CA  . ASN   B 1 115 ? -33.69766 17.28863  -72.78022 1.000 46.55168 ? 115 ASN   B CA  1 
ATOM   2817 C  C   . ASN   B 1 115 ? -34.41956 16.50571  -71.68342 1.000 43.07119 ? 115 ASN   B C   1 
ATOM   2818 O  O   . ASN   B 1 115 ? -34.37604 16.85429  -70.50049 1.000 41.99747 ? 115 ASN   B O   1 
ATOM   2819 C  CB  . ASN   B 1 115 ? -33.04283 18.55615  -72.21975 1.000 38.12310 ? 115 ASN   B CB  1 
ATOM   2820 C  CG  . ASN   B 1 115 ? -31.71811 18.27425  -71.51329 1.000 37.62955 ? 115 ASN   B CG  1 
ATOM   2821 O  OD1 . ASN   B 1 115 ? -31.14202 17.19055  -71.64664 1.000 31.74822 ? 115 ASN   B OD1 1 
ATOM   2822 N  ND2 . ASN   B 1 115 ? -31.22316 19.26398  -70.76649 1.000 42.23693 ? 115 ASN   B ND2 1 
ATOM   2823 N  N   . ARG   B 1 116 ? -35.12849 15.45689  -72.09814 1.000 37.65888 ? 116 ARG   B N   1 
ATOM   2824 C  CA  . ARG   B 1 116 ? -35.77377 14.54762  -71.15989 1.000 33.22635 ? 116 ARG   B CA  1 
ATOM   2825 C  C   . ARG   B 1 116 ? -35.72280 13.11918  -71.68012 1.000 33.70411 ? 116 ARG   B C   1 
ATOM   2826 O  O   . ARG   B 1 116 ? -36.76710 12.46218  -71.74664 1.000 36.65888 ? 116 ARG   B O   1 
ATOM   2827 C  CB  . ARG   B 1 116 ? -37.23559 14.93437  -70.90988 1.000 39.43034 ? 116 ARG   B CB  1 
ATOM   2828 C  CG  . ARG   B 1 116 ? -37.47831 16.35008  -70.37781 1.000 39.56441 ? 116 ARG   B CG  1 
ATOM   2829 C  CD  . ARG   B 1 116 ? -37.30613 16.43058  -68.86843 1.000 40.96743 ? 116 ARG   B CD  1 
ATOM   2830 N  NE  . ARG   B 1 116 ? -37.47851 17.78927  -68.35227 1.000 37.79237 ? 116 ARG   B NE  1 
ATOM   2831 C  CZ  . ARG   B 1 116 ? -37.25530 18.13484  -67.08705 1.000 40.05001 ? 116 ARG   B CZ  1 
ATOM   2832 N  NH1 . ARG   B 1 116 ? -36.86008 17.21550  -66.20905 1.000 35.26368 ? 116 ARG   B NH1 1 
ATOM   2833 N  NH2 . ARG   B 1 116 ? -37.43107 19.39046  -66.69000 1.000 36.36567 ? 116 ARG   B NH2 1 
ATOM   2834 N  N   . PRO   B 1 117 ? -34.55448 12.59176  -72.06621 1.000 36.19339 ? 117 PRO   B N   1 
ATOM   2835 C  CA  . PRO   B 1 117 ? -34.51927 11.17604  -72.44430 1.000 31.62788 ? 117 PRO   B CA  1 
ATOM   2836 C  C   . PRO   B 1 117 ? -34.72659 10.24577  -71.26364 1.000 38.75548 ? 117 PRO   B C   1 
ATOM   2837 O  O   . PRO   B 1 117 ? -35.25029 9.13941   -71.44466 1.000 36.52082 ? 117 PRO   B O   1 
ATOM   2838 C  CB  . PRO   B 1 117 ? -33.12316 11.01398  -73.05413 1.000 38.01957 ? 117 PRO   B CB  1 
ATOM   2839 C  CG  . PRO   B 1 117 ? -32.31666 12.02182  -72.35608 1.000 36.28156 ? 117 PRO   B CG  1 
ATOM   2840 C  CD  . PRO   B 1 117 ? -33.21546 13.20242  -72.17499 1.000 32.09680 ? 117 PRO   B CD  1 
ATOM   2841 N  N   . LEU   B 1 118 ? -34.32125 10.64233  -70.05563 1.000 36.40618 ? 118 LEU   B N   1 
ATOM   2842 C  CA  . LEU   B 1 118 ? -34.54912 9.76484   -68.91439 1.000 34.96684 ? 118 LEU   B CA  1 
ATOM   2843 C  C   . LEU   B 1 118 ? -36.04331 9.61641   -68.64703 1.000 32.55403 ? 118 LEU   B C   1 
ATOM   2844 O  O   . LEU   B 1 118 ? -36.57120 8.50052   -68.65404 1.000 32.07689 ? 118 LEU   B O   1 
ATOM   2845 C  CB  . LEU   B 1 118 ? -33.80777 10.28917  -67.68230 1.000 32.27048 ? 118 LEU   B CB  1 
ATOM   2846 C  CG  . LEU   B 1 118 ? -33.78440 9.41231   -66.43561 1.000 25.62306 ? 118 LEU   B CG  1 
ATOM   2847 C  CD1 . LEU   B 1 118 ? -33.10584 8.10302   -66.74256 1.000 24.81493 ? 118 LEU   B CD1 1 
ATOM   2848 C  CD2 . LEU   B 1 118 ? -33.09027 10.14371  -65.28545 1.000 29.84562 ? 118 LEU   B CD2 1 
ATOM   2849 N  N   . THR   B 1 119 ? -36.74979 10.73971  -68.46142 1.000 37.92095 ? 119 THR   B N   1 
ATOM   2850 C  CA  . THR   B 1 119 ? -38.19565 10.69111  -68.24097 1.000 34.86874 ? 119 THR   B CA  1 
ATOM   2851 C  C   . THR   B 1 119 ? -38.91567 9.86534   -69.30169 1.000 41.35084 ? 119 THR   B C   1 
ATOM   2852 O  O   . THR   B 1 119 ? -39.81544 9.08574   -68.97544 1.000 47.70495 ? 119 THR   B O   1 
ATOM   2853 C  CB  . THR   B 1 119 ? -38.78458 12.09534  -68.20871 1.000 34.83533 ? 119 THR   B CB  1 
ATOM   2854 O  OG1 . THR   B 1 119 ? -38.18982 12.84392  -67.14981 1.000 34.61071 ? 119 THR   B OG1 1 
ATOM   2855 C  CG2 . THR   B 1 119 ? -40.28033 12.02914  -67.95861 1.000 45.08623 ? 119 THR   B CG2 1 
ATOM   2856 N  N   . VAL   B 1 120 ? -38.53901 10.00804  -70.57632 1.000 43.78712 ? 120 VAL   B N   1 
ATOM   2857 C  CA  . VAL   B 1 120 ? -39.30164 9.29797   -71.60319 1.000 43.53663 ? 120 VAL   B CA  1 
ATOM   2858 C  C   . VAL   B 1 120 ? -38.84862 7.85037   -71.72906 1.000 40.46032 ? 120 VAL   B C   1 
ATOM   2859 O  O   . VAL   B 1 120 ? -39.67380 6.95933   -71.94438 1.000 44.90067 ? 120 VAL   B O   1 
ATOM   2860 C  CB  . VAL   B 1 120 ? -39.25253 10.03048  -72.95973 1.000 44.15429 ? 120 VAL   B CB  1 
ATOM   2861 C  CG1 . VAL   B 1 120 ? -39.71948 11.46799  -72.79722 1.000 40.28864 ? 120 VAL   B CG1 1 
ATOM   2862 C  CG2 . VAL   B 1 120 ? -37.86545 9.97265   -73.57727 1.000 47.61949 ? 120 VAL   B CG2 1 
ATOM   2863 N  N   . ILE   B 1 121 ? -37.54878 7.57348   -71.59697 1.000 38.75908 ? 121 ILE   B N   1 
ATOM   2864 C  CA  . ILE   B 1 121 ? -37.10671 6.19026   -71.75792 1.000 40.28927 ? 121 ILE   B CA  1 
ATOM   2865 C  C   . ILE   B 1 121 ? -37.50823 5.35785   -70.54624 1.000 42.79768 ? 121 ILE   B C   1 
ATOM   2866 O  O   . ILE   B 1 121 ? -37.77674 4.15409   -70.66895 1.000 37.20713 ? 121 ILE   B O   1 
ATOM   2867 C  CB  . ILE   B 1 121 ? -35.59043 6.14128   -72.03284 1.000 41.65600 ? 121 ILE   B CB  1 
ATOM   2868 C  CG1 . ILE   B 1 121 ? -35.31489 6.56186   -73.47774 1.000 48.40292 ? 121 ILE   B CG1 1 
ATOM   2869 C  CG2 . ILE   B 1 121 ? -35.02208 4.75411   -71.79707 1.000 34.37488 ? 121 ILE   B CG2 1 
ATOM   2870 C  CD1 . ILE   B 1 121 ? -34.01337 7.31325   -73.67466 1.000 43.03895 ? 121 ILE   B CD1 1 
ATOM   2871 N  N   . MET   B 1 122 ? -37.57376 5.98246   -69.36555 1.000 44.39247 ? 122 MET   B N   1 
ATOM   2872 C  CA  . MET   B 1 122 ? -38.12149 5.31112   -68.18855 1.000 42.87311 ? 122 MET   B CA  1 
ATOM   2873 C  C   . MET   B 1 122 ? -39.63313 5.12836   -68.30371 1.000 47.92610 ? 122 MET   B C   1 
ATOM   2874 O  O   . MET   B 1 122 ? -40.17151 4.08377   -67.92124 1.000 51.01423 ? 122 MET   B O   1 
ATOM   2875 C  CB  . MET   B 1 122 ? -37.78476 6.10124   -66.92797 1.000 35.10225 ? 122 MET   B CB  1 
ATOM   2876 C  CG  . MET   B 1 122 ? -36.36705 5.94430   -66.43803 1.000 31.74061 ? 122 MET   B CG  1 
ATOM   2877 S  SD  . MET   B 1 122 ? -36.02586 4.26077   -65.91324 1.000 38.60737 ? 122 MET   B SD  1 
ATOM   2878 C  CE  . MET   B 1 122 ? -36.90584 4.27262   -64.35294 1.000 30.83894 ? 122 MET   B CE  1 
ATOM   2879 N  N   . HIS   B 1 123 ? -40.34143 6.14983   -68.78467 1.000 47.60759 ? 123 HIS   B N   1 
ATOM   2880 C  CA  . HIS   B 1 123 ? -41.76488 6.00396   -69.07738 1.000 49.07598 ? 123 HIS   B CA  1 
ATOM   2881 C  C   . HIS   B 1 123 ? -42.01753 4.78249   -69.95203 1.000 50.51013 ? 123 HIS   B C   1 
ATOM   2882 O  O   . HIS   B 1 123 ? -42.72949 3.84956   -69.56151 1.000 49.18177 ? 123 HIS   B O   1 
ATOM   2883 C  CB  . HIS   B 1 123 ? -42.27293 7.26241   -69.77288 1.000 45.82167 ? 123 HIS   B CB  1 
ATOM   2884 C  CG  . HIS   B 1 123 ? -43.72841 7.53497   -69.55784 1.000 63.45192 ? 123 HIS   B CG  1 
ATOM   2885 N  ND1 . HIS   B 1 123 ? -44.67458 6.53630   -69.44627 1.000 60.48359 ? 123 HIS   B ND1 1 
ATOM   2886 C  CD2 . HIS   B 1 123 ? -44.40154 8.70410   -69.44359 1.000 63.18380 ? 123 HIS   B CD2 1 
ATOM   2887 C  CE1 . HIS   B 1 123 ? -45.86588 7.08236   -69.26887 1.000 59.33529 ? 123 HIS   B CE1 1 
ATOM   2888 N  NE2 . HIS   B 1 123 ? -45.72736 8.39669   -69.26256 1.000 59.67275 ? 123 HIS   B NE2 1 
ATOM   2889 N  N   . THR   B 1 124 ? -41.41266 4.77726   -71.14359 1.000 47.36980 ? 124 THR   B N   1 
ATOM   2890 C  CA  . THR   B 1 124 ? -41.56204 3.66416   -72.07232 1.000 50.68956 ? 124 THR   B CA  1 
ATOM   2891 C  C   . THR   B 1 124 ? -41.14581 2.36115   -71.42036 1.000 49.11191 ? 124 THR   B C   1 
ATOM   2892 O  O   . THR   B 1 124 ? -41.82604 1.33908   -71.56148 1.000 56.05631 ? 124 THR   B O   1 
ATOM   2893 C  CB  . THR   B 1 124 ? -40.73225 3.91871   -73.33664 1.000 45.76974 ? 124 THR   B CB  1 
ATOM   2894 O  OG1 . THR   B 1 124 ? -41.28573 5.02477   -74.05512 1.000 44.93538 ? 124 THR   B OG1 1 
ATOM   2895 C  CG2 . THR   B 1 124 ? -40.71838 2.69704   -74.23888 1.000 39.12831 ? 124 THR   B CG2 1 
ATOM   2896 N  N   . ILE   B 1 125 ? -40.03457 2.38474   -70.68056 1.000 49.59090 ? 125 ILE   B N   1 
ATOM   2897 C  CA  . ILE   B 1 125 ? -39.52915 1.15139   -70.08958 1.000 50.94602 ? 125 ILE   B CA  1 
ATOM   2898 C  C   . ILE   B 1 125 ? -40.59046 0.53167   -69.19452 1.000 52.52591 ? 125 ILE   B C   1 
ATOM   2899 O  O   . ILE   B 1 125 ? -40.87067 -0.66758  -69.27518 1.000 43.04344 ? 125 ILE   B O   1 
ATOM   2900 C  CB  . ILE   B 1 125 ? -38.20224 1.39630   -69.34196 1.000 53.08489 ? 125 ILE   B CB  1 
ATOM   2901 C  CG1 . ILE   B 1 125 ? -37.55423 0.07501   -69.06537 1.000 50.08249 ? 125 ILE   B CG1 1 
ATOM   2902 C  CG2 . ILE   B 1 125 ? -38.37842 1.91249   -67.97909 1.000 57.66715 ? 125 ILE   B CG2 1 
ATOM   2903 C  CD1 . ILE   B 1 125 ? -37.53176 -0.64875  -70.23955 1.000 50.02400 ? 125 ILE   B CD1 1 
ATOM   2904 N  N   . PHE   B 1 126 ? -41.25501 1.36392   -68.39000 1.000 54.09218 ? 126 PHE   B N   1 
ATOM   2905 C  CA  . PHE   B 1 126 ? -42.22821 0.85697   -67.43424 1.000 51.78029 ? 126 PHE   B CA  1 
ATOM   2906 C  C   . PHE   B 1 126 ? -43.48352 0.35725   -68.14366 1.000 55.75393 ? 126 PHE   B C   1 
ATOM   2907 O  O   . PHE   B 1 126 ? -43.99306 -0.72394  -67.82057 1.000 53.57032 ? 126 PHE   B O   1 
ATOM   2908 C  CB  . PHE   B 1 126 ? -42.56580 1.94356   -66.40459 1.000 53.36587 ? 126 PHE   B CB  1 
ATOM   2909 C  CG  . PHE   B 1 126 ? -41.56985 2.04773   -65.25782 1.000 57.17036 ? 126 PHE   B CG  1 
ATOM   2910 C  CD1 . PHE   B 1 126 ? -40.27528 1.57432   -65.38709 1.000 55.47109 ? 126 PHE   B CD1 1 
ATOM   2911 C  CD2 . PHE   B 1 126 ? -41.95198 2.58667   -64.03436 1.000 50.95895 ? 126 PHE   B CD2 1 
ATOM   2912 C  CE1 . PHE   B 1 126 ? -39.36822 1.64623   -64.33042 1.000 50.78545 ? 126 PHE   B CE1 1 
ATOM   2913 C  CE2 . PHE   B 1 126 ? -41.05665 2.67108   -62.97899 1.000 51.44257 ? 126 PHE   B CE2 1 
ATOM   2914 C  CZ  . PHE   B 1 126 ? -39.75951 2.20033   -63.13129 1.000 50.27294 ? 126 PHE   B CZ  1 
ATOM   2915 N  N   . GLN   B 1 127 ? -43.97787 1.12048   -69.13181 1.000 56.07415 ? 127 GLN   B N   1 
ATOM   2916 C  CA  . GLN   B 1 127 ? -45.16793 0.72086   -69.88479 1.000 58.21868 ? 127 GLN   B CA  1 
ATOM   2917 C  C   . GLN   B 1 127 ? -44.91091 -0.50503  -70.75398 1.000 51.63425 ? 127 GLN   B C   1 
ATOM   2918 O  O   . GLN   B 1 127 ? -45.85275 -1.23278  -71.08084 1.000 59.97238 ? 127 GLN   B O   1 
ATOM   2919 C  CB  . GLN   B 1 127 ? -45.66822 1.88185   -70.75185 1.000 54.34613 ? 127 GLN   B CB  1 
ATOM   2920 C  CG  . GLN   B 1 127 ? -46.39107 2.98788   -69.98753 1.000 56.95145 ? 127 GLN   B CG  1 
ATOM   2921 C  CD  . GLN   B 1 127 ? -47.82865 2.62035   -69.60710 1.000 56.50436 ? 127 GLN   B CD  1 
ATOM   2922 O  OE1 . GLN   B 1 127 ? -48.35127 1.58163   -70.01962 1.000 60.19292 ? 127 GLN   B OE1 1 
ATOM   2923 N  NE2 . GLN   B 1 127 ? -48.47044 3.47972   -68.81769 1.000 46.40581 ? 127 GLN   B NE2 1 
ATOM   2924 N  N   . GLU   B 1 128 ? -43.65774 -0.74147  -71.14848 1.000 49.28004 ? 128 GLU   B N   1 
ATOM   2925 C  CA  . GLU   B 1 128 ? -43.31343 -1.95903  -71.87784 1.000 51.80719 ? 128 GLU   B CA  1 
ATOM   2926 C  C   . GLU   B 1 128 ? -43.29921 -3.17223  -70.95974 1.000 51.72930 ? 128 GLU   B C   1 
ATOM   2927 O  O   . GLU   B 1 128 ? -43.48047 -4.30365  -71.42293 1.000 52.70373 ? 128 GLU   B O   1 
ATOM   2928 C  CB  . GLU   B 1 128 ? -41.95055 -1.78781  -72.56781 1.000 50.25358 ? 128 GLU   B CB  1 
ATOM   2929 C  CG  . GLU   B 1 128 ? -41.27298 -3.07106  -73.06116 1.000 44.31804 ? 128 GLU   B CG  1 
ATOM   2930 C  CD  . GLU   B 1 128 ? -41.64283 -3.41863  -74.49426 1.000 53.47732 ? 128 GLU   B CD  1 
ATOM   2931 O  OE1 . GLU   B 1 128 ? -41.19796 -4.48166  -74.99568 1.000 46.77589 ? 128 GLU   B OE1 1 
ATOM   2932 O  OE2 . GLU   B 1 128 ? -42.37356 -2.62027  -75.12126 1.000 44.34665 ? 128 GLU   B OE2 1 
ATOM   2933 N  N   . ARG   B 1 129 ? -43.09479 -2.95201  -69.66397 1.000 57.31185 ? 129 ARG   B N   1 
ATOM   2934 C  CA  . ARG   B 1 129 ? -43.04194 -4.00874  -68.66569 1.000 57.13709 ? 129 ARG   B CA  1 
ATOM   2935 C  C   . ARG   B 1 129 ? -44.32763 -4.12557  -67.86887 1.000 54.43804 ? 129 ARG   B C   1 
ATOM   2936 O  O   . ARG   B 1 129 ? -44.43701 -5.02375  -67.02815 1.000 52.01962 ? 129 ARG   B O   1 
ATOM   2937 C  CB  . ARG   B 1 129 ? -41.89753 -3.74740  -67.69239 1.000 55.33527 ? 129 ARG   B CB  1 
ATOM   2938 C  CG  . ARG   B 1 129 ? -40.59155 -3.36394  -68.33194 1.000 55.07097 ? 129 ARG   B CG  1 
ATOM   2939 C  CD  . ARG   B 1 129 ? -39.53457 -4.27140  -67.87522 1.000 52.60212 ? 129 ARG   B CD  1 
ATOM   2940 N  NE  . ARG   B 1 129 ? -38.44913 -4.43768  -68.83854 1.000 40.32080 ? 129 ARG   B NE  1 
ATOM   2941 C  CZ  . ARG   B 1 129 ? -37.55689 -5.41842  -68.75635 1.000 40.64122 ? 129 ARG   B CZ  1 
ATOM   2942 N  NH1 . ARG   B 1 129 ? -37.64758 -6.30898  -67.76851 1.000 44.38378 ? 129 ARG   B NH1 1 
ATOM   2943 N  NH2 . ARG   B 1 129 ? -36.60003 -5.52588  -69.66240 1.000 39.73187 ? 129 ARG   B NH2 1 
ATOM   2944 N  N   . ASP   B 1 130 ? -45.27218 -3.20478  -68.07721 1.000 58.03885 ? 130 ASP   B N   1 
ATOM   2945 C  CA  . ASP   B 1 130 ? -46.50590 -3.12803  -67.29757 1.000 61.39498 ? 130 ASP   B CA  1 
ATOM   2946 C  C   . ASP   B 1 130 ? -46.22311 -2.97326  -65.79814 1.000 67.11388 ? 130 ASP   B C   1 
ATOM   2947 O  O   . ASP   B 1 130 ? -46.99311 -3.44657  -64.95163 1.000 58.85535 ? 130 ASP   B O   1 
ATOM   2948 C  CB  . ASP   B 1 130 ? -47.39889 -4.34433  -67.56936 1.000 61.18726 ? 130 ASP   B CB  1 
ATOM   2949 C  CG  . ASP   B 1 130 ? -48.85160 -3.96573  -67.73372 1.000 67.10189 ? 130 ASP   B CG  1 
ATOM   2950 O  OD1 . ASP   B 1 130 ? -49.13915 -2.75232  -67.79159 1.000 67.40873 ? 130 ASP   B OD1 1 
ATOM   2951 O  OD2 . ASP   B 1 130 ? -49.70539 -4.87342  -67.81143 1.000 77.07567 ? 130 ASP   B OD2 1 
ATOM   2952 N  N   . LEU   B 1 131 ? -45.11273 -2.30794  -65.45179 1.000 60.48282 ? 131 LEU   B N   1 
ATOM   2953 C  CA  . LEU   B 1 131 ? -44.79459 -2.11612  -64.04184 1.000 51.95176 ? 131 LEU   B CA  1 
ATOM   2954 C  C   . LEU   B 1 131 ? -45.76450 -1.16144  -63.37832 1.000 52.39660 ? 131 LEU   B C   1 
ATOM   2955 O  O   . LEU   B 1 131 ? -45.97047 -1.24467  -62.16305 1.000 55.39339 ? 131 LEU   B O   1 
ATOM   2956 C  CB  . LEU   B 1 131 ? -43.36820 -1.59784  -63.85816 1.000 52.20942 ? 131 LEU   B CB  1 
ATOM   2957 C  CG  . LEU   B 1 131 ? -42.28608 -2.29945  -64.66123 1.000 51.69717 ? 131 LEU   B CG  1 
ATOM   2958 C  CD1 . LEU   B 1 131 ? -41.03150 -1.46380  -64.72033 1.000 49.90075 ? 131 LEU   B CD1 1 
ATOM   2959 C  CD2 . LEU   B 1 131 ? -41.99649 -3.68719  -64.08298 1.000 48.92850 ? 131 LEU   B CD2 1 
ATOM   2960 N  N   . LEU   B 1 132 ? -46.36214 -0.25089  -64.14591 1.000 45.75724 ? 132 LEU   B N   1 
ATOM   2961 C  CA  . LEU   B 1 132 ? -47.27840 0.71140   -63.54828 1.000 56.48999 ? 132 LEU   B CA  1 
ATOM   2962 C  C   . LEU   B 1 132 ? -48.53477 0.05933   -62.99232 1.000 56.02565 ? 132 LEU   B C   1 
ATOM   2963 O  O   . LEU   B 1 132 ? -49.18248 0.63217   -62.11088 1.000 49.44570 ? 132 LEU   B O   1 
ATOM   2964 C  CB  . LEU   B 1 132 ? -47.67363 1.76662   -64.56708 1.000 52.19580 ? 132 LEU   B CB  1 
ATOM   2965 C  CG  . LEU   B 1 132 ? -46.51229 2.58683   -65.09126 1.000 50.17069 ? 132 LEU   B CG  1 
ATOM   2966 C  CD1 . LEU   B 1 132 ? -46.17342 2.17058   -66.51549 1.000 45.95422 ? 132 LEU   B CD1 1 
ATOM   2967 C  CD2 . LEU   B 1 132 ? -46.89259 4.04030   -64.98489 1.000 41.19179 ? 132 LEU   B CD2 1 
ATOM   2968 N  N   . LYS   B 1 133 ? -48.90235 -1.10935  -63.49787 1.000 57.59267 ? 133 LYS   B N   1 
ATOM   2969 C  CA  . LYS   B 1 133 ? -50.05151 -1.83167  -62.99106 1.000 58.87497 ? 133 LYS   B CA  1 
ATOM   2970 C  C   . LYS   B 1 133 ? -49.65607 -3.10891  -62.26632 1.000 63.65383 ? 133 LYS   B C   1 
ATOM   2971 O  O   . LYS   B 1 133 ? -50.50989 -3.73129  -61.62314 1.000 62.69070 ? 133 LYS   B O   1 
ATOM   2972 C  CB  . LYS   B 1 133 ? -51.02148 -2.13917  -64.14372 1.000 68.75211 ? 133 LYS   B CB  1 
ATOM   2973 C  CG  . LYS   B 1 133 ? -51.52248 -0.87796  -64.86243 1.000 72.84615 ? 133 LYS   B CG  1 
ATOM   2974 C  CD  . LYS   B 1 133 ? -52.06433 -1.18076  -66.25951 1.000 78.65634 ? 133 LYS   B CD  1 
ATOM   2975 C  CE  . LYS   B 1 133 ? -53.39815 -1.91650  -66.21123 1.000 81.63360 ? 133 LYS   B CE  1 
ATOM   2976 N  NZ  . LYS   B 1 133 ? -53.78508 -2.46035  -67.54957 1.000 74.15488 ? 133 LYS   B NZ  1 
ATOM   2977 N  N   . THR   B 1 134 ? -48.38877 -3.51617  -62.35581 1.000 56.63203 ? 134 THR   B N   1 
ATOM   2978 C  CA  . THR   B 1 134 ? -47.89441 -4.55315  -61.46600 1.000 48.69465 ? 134 THR   B CA  1 
ATOM   2979 C  C   . THR   B 1 134 ? -47.65074 -3.99354  -60.07048 1.000 53.66523 ? 134 THR   B C   1 
ATOM   2980 O  O   . THR   B 1 134 ? -47.96242 -4.64897  -59.06883 1.000 57.55440 ? 134 THR   B O   1 
ATOM   2981 C  CB  . THR   B 1 134 ? -46.61896 -5.16712  -62.03564 1.000 44.68301 ? 134 THR   B CB  1 
ATOM   2982 O  OG1 . THR   B 1 134 ? -46.95352 -6.02194  -63.13383 1.000 43.51103 ? 134 THR   B OG1 1 
ATOM   2983 C  CG2 . THR   B 1 134 ? -45.87749 -5.97372  -60.97570 1.000 45.36385 ? 134 THR   B CG2 1 
ATOM   2984 N  N   . PHE   B 1 135 ? -47.12287 -2.77416  -59.98195 1.000 49.88008 ? 135 PHE   B N   1 
ATOM   2985 C  CA  . PHE   B 1 135 ? -46.83380 -2.14761  -58.69874 1.000 45.43019 ? 135 PHE   B CA  1 
ATOM   2986 C  C   . PHE   B 1 135 ? -47.74300 -0.96109  -58.43429 1.000 50.55342 ? 135 PHE   B C   1 
ATOM   2987 O  O   . PHE   B 1 135 ? -47.44561 -0.13781  -57.56089 1.000 49.87696 ? 135 PHE   B O   1 
ATOM   2988 C  CB  . PHE   B 1 135 ? -45.36197 -1.74022  -58.62939 1.000 42.49052 ? 135 PHE   B CB  1 
ATOM   2989 C  CG  . PHE   B 1 135 ? -44.42490 -2.91133  -58.68918 1.000 40.82532 ? 135 PHE   B CG  1 
ATOM   2990 C  CD1 . PHE   B 1 135 ? -44.22135 -3.71093  -57.57015 1.000 45.31453 ? 135 PHE   B CD1 1 
ATOM   2991 C  CD2 . PHE   B 1 135 ? -43.78669 -3.24584  -59.86770 1.000 35.10606 ? 135 PHE   B CD2 1 
ATOM   2992 C  CE1 . PHE   B 1 135 ? -43.38019 -4.79487  -57.61563 1.000 29.45221 ? 135 PHE   B CE1 1 
ATOM   2993 C  CE2 . PHE   B 1 135 ? -42.95219 -4.33299  -59.91946 1.000 34.92730 ? 135 PHE   B CE2 1 
ATOM   2994 C  CZ  . PHE   B 1 135 ? -42.74937 -5.10968  -58.78622 1.000 32.26768 ? 135 PHE   B CZ  1 
ATOM   2995 N  N   . LYS   B 1 136 ? -48.84832 -0.87188  -59.17505 1.000 46.50733 ? 136 LYS   B N   1 
ATOM   2996 C  CA  . LYS   B 1 136 ? -49.86565 0.15643   -58.98613 1.000 51.40781 ? 136 LYS   B CA  1 
ATOM   2997 C  C   . LYS   B 1 136 ? -49.22290 1.54008   -58.92301 1.000 52.03803 ? 136 LYS   B C   1 
ATOM   2998 O  O   . LYS   B 1 136 ? -49.46869 2.33789   -58.01556 1.000 55.74496 ? 136 LYS   B O   1 
ATOM   2999 C  CB  . LYS   B 1 136 ? -50.72116 -0.14481  -57.75369 1.000 50.70619 ? 136 LYS   B CB  1 
ATOM   3000 C  CG  . LYS   B 1 136 ? -51.26984 -1.57756  -57.76731 1.000 54.04306 ? 136 LYS   B CG  1 
ATOM   3001 C  CD  . LYS   B 1 136 ? -52.63592 -1.69322  -57.09096 1.000 56.21875 ? 136 LYS   B CD  1 
ATOM   3002 C  CE  . LYS   B 1 136 ? -52.51436 -1.76944  -55.58345 1.000 48.87696 ? 136 LYS   B CE  1 
ATOM   3003 N  NZ  . LYS   B 1 136 ? -51.40565 -2.67684  -55.16739 1.000 50.83185 ? 136 LYS   B NZ  1 
ATOM   3004 N  N   . ILE   B 1 137 ? -48.38438 1.80139   -59.92111 1.000 54.43673 ? 137 ILE   B N   1 
ATOM   3005 C  CA  . ILE   B 1 137 ? -47.64744 3.06591   -60.01788 1.000 52.58316 ? 137 ILE   B CA  1 
ATOM   3006 C  C   . ILE   B 1 137 ? -48.54771 4.06844   -60.72663 1.000 45.29750 ? 137 ILE   B C   1 
ATOM   3007 O  O   . ILE   B 1 137 ? -48.76021 3.95168   -61.94427 1.000 45.71186 ? 137 ILE   B O   1 
ATOM   3008 C  CB  . ILE   B 1 137 ? -46.32718 2.88255   -60.78046 1.000 44.34237 ? 137 ILE   B CB  1 
ATOM   3009 C  CG1 . ILE   B 1 137 ? -45.63518 1.58949   -60.36345 1.000 45.48790 ? 137 ILE   B CG1 1 
ATOM   3010 C  CG2 . ILE   B 1 137 ? -45.41826 4.05013   -60.51297 1.000 38.12081 ? 137 ILE   B CG2 1 
ATOM   3011 C  CD1 . ILE   B 1 137 ? -44.29096 1.40890   -61.00402 1.000 46.13610 ? 137 ILE   B CD1 1 
ATOM   3012 N  N   . PRO   B 1 138 ? -49.08095 5.06542   -60.02158 1.000 40.16797 ? 138 PRO   B N   1 
ATOM   3013 C  CA  . PRO   B 1 138 ? -49.82479 6.12533   -60.71018 1.000 47.56903 ? 138 PRO   B CA  1 
ATOM   3014 C  C   . PRO   B 1 138 ? -48.89258 6.85961   -61.66139 1.000 49.69584 ? 138 PRO   B C   1 
ATOM   3015 O  O   . PRO   B 1 138 ? -47.88354 7.43607   -61.24735 1.000 46.67184 ? 138 PRO   B O   1 
ATOM   3016 C  CB  . PRO   B 1 138 ? -50.30602 7.02481   -59.56227 1.000 45.56731 ? 138 PRO   B CB  1 
ATOM   3017 C  CG  . PRO   B 1 138 ? -49.96182 6.29859   -58.29241 1.000 44.64464 ? 138 PRO   B CG  1 
ATOM   3018 C  CD  . PRO   B 1 138 ? -48.82231 5.39808   -58.61779 1.000 47.00885 ? 138 PRO   B CD  1 
ATOM   3019 N  N   . VAL   B 1 139 ? -49.21923 6.80944   -62.95614 1.000 53.32961 ? 139 VAL   B N   1 
ATOM   3020 C  CA  . VAL   B 1 139 ? -48.31552 7.36657   -63.96117 1.000 46.61497 ? 139 VAL   B CA  1 
ATOM   3021 C  C   . VAL   B 1 139 ? -48.03718 8.83726   -63.69241 1.000 47.78789 ? 139 VAL   B C   1 
ATOM   3022 O  O   . VAL   B 1 139 ? -46.94666 9.33496   -63.99962 1.000 50.92307 ? 139 VAL   B O   1 
ATOM   3023 C  CB  . VAL   B 1 139 ? -48.87292 7.14470   -65.38127 1.000 48.46788 ? 139 VAL   B CB  1 
ATOM   3024 C  CG1 . VAL   B 1 139 ? -49.90573 8.20136   -65.73353 1.000 50.43331 ? 139 VAL   B CG1 1 
ATOM   3025 C  CG2 . VAL   B 1 139 ? -47.74063 7.15525   -66.38574 1.000 55.15633 ? 139 VAL   B CG2 1 
ATOM   3026 N  N   . ASP   B 1 140 ? -48.99912 9.55748   -63.10824 1.000 50.95586 ? 140 ASP   B N   1 
ATOM   3027 C  CA  . ASP   B 1 140 ? -48.71908 10.93014  -62.69949 1.000 49.30878 ? 140 ASP   B CA  1 
ATOM   3028 C  C   . ASP   B 1 140 ? -47.62134 10.96127  -61.64238 1.000 52.39197 ? 140 ASP   B C   1 
ATOM   3029 O  O   . ASP   B 1 140 ? -46.71937 11.80863  -61.69248 1.000 45.29453 ? 140 ASP   B O   1 
ATOM   3030 C  CB  . ASP   B 1 140 ? -49.99112 11.60119  -62.18278 1.000 51.21769 ? 140 ASP   B CB  1 
ATOM   3031 C  CG  . ASP   B 1 140 ? -50.68787 10.78375  -61.09934 1.000 56.18723 ? 140 ASP   B CG  1 
ATOM   3032 O  OD1 . ASP   B 1 140 ? -50.78927 9.54587   -61.26604 1.000 52.87512 ? 140 ASP   B OD1 1 
ATOM   3033 O  OD2 . ASP   B 1 140 ? -51.12210 11.37531  -60.07928 1.000 52.71329 ? 140 ASP   B OD2 1 
ATOM   3034 N  N   . THR   B 1 141 ? -47.67768 10.03102  -60.68308 1.000 51.00586 ? 141 THR   B N   1 
ATOM   3035 C  CA  . THR   B 1 141 ? -46.62277 9.92596   -59.67979 1.000 54.58937 ? 141 THR   B CA  1 
ATOM   3036 C  C   . THR   B 1 141 ? -45.29165 9.57882   -60.32980 1.000 47.38709 ? 141 THR   B C   1 
ATOM   3037 O  O   . THR   B 1 141 ? -44.25455 10.16962  -60.00179 1.000 45.03416 ? 141 THR   B O   1 
ATOM   3038 C  CB  . THR   B 1 141 ? -46.98250 8.87421   -58.62368 1.000 52.74181 ? 141 THR   B CB  1 
ATOM   3039 O  OG1 . THR   B 1 141 ? -48.14933 9.28818   -57.90048 1.000 44.23992 ? 141 THR   B OG1 1 
ATOM   3040 C  CG2 . THR   B 1 141 ? -45.81505 8.68415   -57.65162 1.000 41.44739 ? 141 THR   B CG2 1 
ATOM   3041 N  N   . LEU   B 1 142 ? -45.30599 8.61816   -61.25827 1.000 41.43702 ? 142 LEU   B N   1 
ATOM   3042 C  CA  . LEU   B 1 142 ? -44.08631 8.23570   -61.95586 1.000 38.96513 ? 142 LEU   B CA  1 
ATOM   3043 C  C   . LEU   B 1 142 ? -43.47198 9.42034   -62.69857 1.000 47.26621 ? 142 LEU   B C   1 
ATOM   3044 O  O   . LEU   B 1 142 ? -42.28504 9.72711   -62.52205 1.000 45.80887 ? 142 LEU   B O   1 
ATOM   3045 C  CB  . LEU   B 1 142 ? -44.38558 7.09312   -62.91781 1.000 43.69287 ? 142 LEU   B CB  1 
ATOM   3046 C  CG  . LEU   B 1 142 ? -43.16406 6.56822   -63.67225 1.000 46.58320 ? 142 LEU   B CG  1 
ATOM   3047 C  CD1 . LEU   B 1 142 ? -42.04670 6.16232   -62.70886 1.000 48.25605 ? 142 LEU   B CD1 1 
ATOM   3048 C  CD2 . LEU   B 1 142 ? -43.55864 5.41504   -64.55889 1.000 42.41368 ? 142 LEU   B CD2 1 
ATOM   3049 N  N   . ILE   B 1 143 ? -44.26528 10.08904  -63.54505 1.000 35.18196 ? 143 ILE   B N   1 
ATOM   3050 C  CA  . ILE   B 1 143 ? -43.77881 11.25478  -64.28512 1.000 44.76073 ? 143 ILE   B CA  1 
ATOM   3051 C  C   . ILE   B 1 143 ? -43.10660 12.23168  -63.33767 1.000 42.89562 ? 143 ILE   B C   1 
ATOM   3052 O  O   . ILE   B 1 143 ? -41.93318 12.58755  -63.50336 1.000 43.32560 ? 143 ILE   B O   1 
ATOM   3053 C  CB  . ILE   B 1 143 ? -44.92670 11.94959  -65.03957 1.000 42.80058 ? 143 ILE   B CB  1 
ATOM   3054 C  CG1 . ILE   B 1 143 ? -45.39629 11.11386  -66.21509 1.000 42.23081 ? 143 ILE   B CG1 1 
ATOM   3055 C  CG2 . ILE   B 1 143 ? -44.46355 13.30367  -65.56529 1.000 33.24147 ? 143 ILE   B CG2 1 
ATOM   3056 C  CD1 . ILE   B 1 143 ? -44.45444 11.19886  -67.37488 1.000 43.86747 ? 143 ILE   B CD1 1 
ATOM   3057 N  N   . THR   B 1 144 ? -43.85996 12.67240  -62.32808 1.000 36.36848 ? 144 THR   B N   1 
ATOM   3058 C  CA  . THR   B 1 144 ? -43.37403 13.67483  -61.39011 1.000 40.38046 ? 144 THR   B CA  1 
ATOM   3059 C  C   . THR   B 1 144 ? -41.99935 13.30820  -60.84670 1.000 40.35046 ? 144 THR   B C   1 
ATOM   3060 O  O   . THR   B 1 144 ? -41.11662 14.16797  -60.73480 1.000 30.07316 ? 144 THR   B O   1 
ATOM   3061 C  CB  . THR   B 1 144 ? -44.37617 13.82484  -60.24164 1.000 46.37066 ? 144 THR   B CB  1 
ATOM   3062 O  OG1 . THR   B 1 144 ? -45.72298 13.84385  -60.75248 1.000 44.73987 ? 144 THR   B OG1 1 
ATOM   3063 C  CG2 . THR   B 1 144 ? -44.09861 15.09851  -59.43623 1.000 41.33864 ? 144 THR   B CG2 1 
ATOM   3064 N  N   . TYR   B 1 145 ? -41.80506 12.02923  -60.50631 1.000 38.45388 ? 145 TYR   B N   1 
ATOM   3065 C  CA  . TYR   B 1 145 ? -40.52501 11.57983  -59.97506 1.000 37.65295 ? 145 TYR   B CA  1 
ATOM   3066 C  C   . TYR   B 1 145 ? -39.44788 11.62760  -61.04851 1.000 32.24625 ? 145 TYR   B C   1 
ATOM   3067 O  O   . TYR   B 1 145 ? -38.45142 12.34237  -60.90396 1.000 32.11683 ? 145 TYR   B O   1 
ATOM   3068 C  CB  . TYR   B 1 145 ? -40.63652 10.16497  -59.39556 1.000 33.99035 ? 145 TYR   B CB  1 
ATOM   3069 C  CG  . TYR   B 1 145 ? -39.28249 9.64966   -58.96138 1.000 30.32995 ? 145 TYR   B CG  1 
ATOM   3070 C  CD1 . TYR   B 1 145 ? -38.62439 10.23040  -57.89365 1.000 26.52214 ? 145 TYR   B CD1 1 
ATOM   3071 C  CD2 . TYR   B 1 145 ? -38.65033 8.61467   -59.64021 1.000 25.46716 ? 145 TYR   B CD2 1 
ATOM   3072 C  CE1 . TYR   B 1 145 ? -37.37707 9.79621   -57.49504 1.000 25.59443 ? 145 TYR   B CE1 1 
ATOM   3073 C  CE2 . TYR   B 1 145 ? -37.39379 8.17376   -59.25168 1.000 30.88431 ? 145 TYR   B CE2 1 
ATOM   3074 C  CZ  . TYR   B 1 145 ? -36.76235 8.77531   -58.16932 1.000 24.75176 ? 145 TYR   B CZ  1 
ATOM   3075 O  OH  . TYR   B 1 145 ? -35.51354 8.35776   -57.75322 1.000 25.07137 ? 145 TYR   B OH  1 
ATOM   3076 N  N   . LEU   B 1 146 ? -39.63890 10.85973  -62.13223 1.000 36.81185 ? 146 LEU   B N   1 
ATOM   3077 C  CA  . LEU   B 1 146 ? -38.71380 10.82958  -63.26523 1.000 39.58111 ? 146 LEU   B CA  1 
ATOM   3078 C  C   . LEU   B 1 146 ? -38.25208 12.21617  -63.68440 1.000 38.26153 ? 146 LEU   B C   1 
ATOM   3079 O  O   . LEU   B 1 146 ? -37.06505 12.44938  -63.92349 1.000 37.45360 ? 146 LEU   B O   1 
ATOM   3080 C  CB  . LEU   B 1 146 ? -39.38460 10.14929  -64.45358 1.000 35.47549 ? 146 LEU   B CB  1 
ATOM   3081 C  CG  . LEU   B 1 146 ? -39.59250 8.65588   -64.34854 1.000 37.96937 ? 146 LEU   B CG  1 
ATOM   3082 C  CD1 . LEU   B 1 146 ? -40.18643 8.18449   -65.65511 1.000 42.26599 ? 146 LEU   B CD1 1 
ATOM   3083 C  CD2 . LEU   B 1 146 ? -38.27432 7.98042   -64.05480 1.000 34.75097 ? 146 LEU   B CD2 1 
ATOM   3084 N  N   . MET   B 1 147 ? -39.20005 13.14130  -63.79983 1.000 38.67138 ? 147 MET   B N   1 
ATOM   3085 C  CA  . MET   B 1 147 ? -38.87486 14.51006  -64.15910 1.000 36.58841 ? 147 MET   B CA  1 
ATOM   3086 C  C   . MET   B 1 147 ? -37.98754 15.15449  -63.10800 1.000 37.52695 ? 147 MET   B C   1 
ATOM   3087 O  O   . MET   B 1 147 ? -36.95502 15.75141  -63.43421 1.000 37.03692 ? 147 MET   B O   1 
ATOM   3088 C  CB  . MET   B 1 147 ? -40.16789 15.30130  -64.32998 1.000 43.00705 ? 147 MET   B CB  1 
ATOM   3089 C  CG  . MET   B 1 147 ? -40.93457 14.91363  -65.56938 1.000 43.56177 ? 147 MET   B CG  1 
ATOM   3090 S  SD  . MET   B 1 147 ? -40.17881 15.72258  -66.97605 1.000 58.15996 ? 147 MET   B SD  1 
ATOM   3091 C  CE  . MET   B 1 147 ? -40.47611 17.43997  -66.55796 1.000 57.91279 ? 147 MET   B CE  1 
ATOM   3092 N  N   . THR   B 1 148 ? -38.39277 15.06047  -61.83461 1.000 34.62669 ? 148 THR   B N   1 
ATOM   3093 C  CA  . THR   B 1 148 ? -37.60233 15.62104  -60.74068 1.000 32.82890 ? 148 THR   B CA  1 
ATOM   3094 C  C   . THR   B 1 148 ? -36.23638 14.95944  -60.64758 1.000 24.11804 ? 148 THR   B C   1 
ATOM   3095 O  O   . THR   B 1 148 ? -35.25557 15.60693  -60.26370 1.000 24.25633 ? 148 THR   B O   1 
ATOM   3096 C  CB  . THR   B 1 148 ? -38.35781 15.46069  -59.42526 1.000 33.75970 ? 148 THR   B CB  1 
ATOM   3097 O  OG1 . THR   B 1 148 ? -39.73040 15.81249  -59.63127 1.000 41.06787 ? 148 THR   B OG1 1 
ATOM   3098 C  CG2 . THR   B 1 148 ? -37.76629 16.35323  -58.35000 1.000 23.15725 ? 148 THR   B CG2 1 
ATOM   3099 N  N   . LEU   B 1 149 ? -36.16457 13.67523  -60.99798 1.000 26.69352 ? 149 LEU   B N   1 
ATOM   3100 C  CA  . LEU   B 1 149 ? -34.88824 12.97969  -61.07676 1.000 30.93881 ? 149 LEU   B CA  1 
ATOM   3101 C  C   . LEU   B 1 149 ? -34.02451 13.55567  -62.19416 1.000 32.86877 ? 149 LEU   B C   1 
ATOM   3102 O  O   . LEU   B 1 149 ? -32.87786 13.94845  -61.95185 1.000 27.15544 ? 149 LEU   B O   1 
ATOM   3103 C  CB  . LEU   B 1 149 ? -35.12772 11.48206  -61.28091 1.000 21.55625 ? 149 LEU   B CB  1 
ATOM   3104 C  CG  . LEU   B 1 149 ? -33.93813 10.51559  -61.34204 1.000 27.28821 ? 149 LEU   B CG  1 
ATOM   3105 C  CD1 . LEU   B 1 149 ? -33.30423 10.32515  -59.98897 1.000 22.30554 ? 149 LEU   B CD1 1 
ATOM   3106 C  CD2 . LEU   B 1 149 ? -34.35392 9.18363   -61.92517 1.000 18.99536 ? 149 LEU   B CD2 1 
ATOM   3107 N  N   . GLU   B 1 150 ? -34.56837 13.62112  -63.42466 1.000 29.02315 ? 150 GLU   B N   1 
ATOM   3108 C  CA  . GLU   B 1 150 ? -33.83503 14.16914  -64.57050 1.000 25.08884 ? 150 GLU   B CA  1 
ATOM   3109 C  C   . GLU   B 1 150 ? -33.25740 15.53958  -64.25628 1.000 31.00175 ? 150 GLU   B C   1 
ATOM   3110 O  O   . GLU   B 1 150 ? -32.11311 15.84066  -64.62026 1.000 34.34085 ? 150 GLU   B O   1 
ATOM   3111 C  CB  . GLU   B 1 150 ? -34.75439 14.25514  -65.79162 1.000 32.85813 ? 150 GLU   B CB  1 
ATOM   3112 C  CG  . GLU   B 1 150 ? -34.02879 14.29577  -67.13508 1.000 35.66487 ? 150 GLU   B CG  1 
ATOM   3113 C  CD  . GLU   B 1 150 ? -34.70894 13.44154  -68.19523 1.000 39.28316 ? 150 GLU   B CD  1 
ATOM   3114 O  OE1 . GLU   B 1 150 ? -35.93178 13.22760  -68.07124 1.000 41.42389 ? 150 GLU   B OE1 1 
ATOM   3115 O  OE2 . GLU   B 1 150 ? -34.03601 12.96754  -69.14406 1.000 31.67881 ? 150 GLU   B OE2 1 
ATOM   3116 N  N   . ASP   B 1 151 ? -34.03518 16.36999  -63.55555 1.000 28.00418 ? 151 ASP   B N   1 
ATOM   3117 C  CA  . ASP   B 1 151 ? -33.60117 17.70022  -63.13972 1.000 29.86641 ? 151 ASP   B CA  1 
ATOM   3118 C  C   . ASP   B 1 151 ? -32.33262 17.68683  -62.29908 1.000 26.40510 ? 151 ASP   B C   1 
ATOM   3119 O  O   . ASP   B 1 151 ? -31.58637 18.67221  -62.29808 1.000 33.69443 ? 151 ASP   B O   1 
ATOM   3120 C  CB  . ASP   B 1 151 ? -34.70374 18.36809  -62.32511 1.000 27.09616 ? 151 ASP   B CB  1 
ATOM   3121 C  CG  . ASP   B 1 151 ? -35.84765 18.85998  -63.17363 1.000 32.50105 ? 151 ASP   B CG  1 
ATOM   3122 O  OD1 . ASP   B 1 151 ? -35.85249 18.62333  -64.40489 1.000 28.56026 ? 151 ASP   B OD1 1 
ATOM   3123 O  OD2 . ASP   B 1 151 ? -36.75069 19.48163  -62.58165 1.000 33.86145 ? 151 ASP   B OD2 1 
ATOM   3124 N  N   . HIS   B 1 152 ? -32.11729 16.64566  -61.49983 1.000 28.03032 ? 152 HIS   B N   1 
ATOM   3125 C  CA  . HIS   B 1 152 ? -30.96240 16.62846  -60.61080 1.000 23.31114 ? 152 HIS   B CA  1 
ATOM   3126 C  C   . HIS   B 1 152 ? -29.75293 16.00629  -61.27296 1.000 23.05812 ? 152 HIS   B C   1 
ATOM   3127 O  O   . HIS   B 1 152 ? -28.71507 15.84052  -60.62185 1.000 18.68467 ? 152 HIS   B O   1 
ATOM   3128 C  CB  . HIS   B 1 152 ? -31.29383 15.90736  -59.29807 1.000 23.95212 ? 152 HIS   B CB  1 
ATOM   3129 C  CG  . HIS   B 1 152 ? -32.17863 16.70431  -58.39500 1.000 18.98066 ? 152 HIS   B CG  1 
ATOM   3130 N  ND1 . HIS   B 1 152 ? -33.54804 16.75838  -58.55470 1.000 23.98525 ? 152 HIS   B ND1 1 
ATOM   3131 C  CD2 . HIS   B 1 152 ? -31.89008 17.50215  -57.34083 1.000 24.52386 ? 152 HIS   B CD2 1 
ATOM   3132 C  CE1 . HIS   B 1 152 ? -34.06505 17.55339  -57.63495 1.000 20.19397 ? 152 HIS   B CE1 1 
ATOM   3133 N  NE2 . HIS   B 1 152 ? -33.08105 18.01457  -56.88370 1.000 32.06435 ? 152 HIS   B NE2 1 
ATOM   3134 N  N   . TYR   B 1 153 ? -29.87918 15.65825  -62.54682 1.000 21.85030 ? 153 TYR   B N   1 
ATOM   3135 C  CA  . TYR   B 1 153 ? -28.73895 15.43189  -63.41600 1.000 25.36440 ? 153 TYR   B CA  1 
ATOM   3136 C  C   . TYR   B 1 153 ? -28.31958 16.77055  -64.01787 1.000 31.18600 ? 153 TYR   B C   1 
ATOM   3137 O  O   . TYR   B 1 153 ? -29.17038 17.55333  -64.46095 1.000 35.90801 ? 153 TYR   B O   1 
ATOM   3138 C  CB  . TYR   B 1 153 ? -29.09531 14.41143  -64.49664 1.000 19.56963 ? 153 TYR   B CB  1 
ATOM   3139 C  CG  . TYR   B 1 153 ? -28.96302 12.97205  -64.03741 1.000 19.26756 ? 153 TYR   B CG  1 
ATOM   3140 C  CD1 . TYR   B 1 153 ? -27.75291 12.30094  -64.15232 1.000 17.78845 ? 153 TYR   B CD1 1 
ATOM   3141 C  CD2 . TYR   B 1 153 ? -30.03956 12.28301  -63.49022 1.000 17.00853 ? 153 TYR   B CD2 1 
ATOM   3142 C  CE1 . TYR   B 1 153 ? -27.61369 10.96929  -63.74303 1.000 18.75536 ? 153 TYR   B CE1 1 
ATOM   3143 C  CE2 . TYR   B 1 153 ? -29.91622 10.93513  -63.08029 1.000 15.36950 ? 153 TYR   B CE2 1 
ATOM   3144 C  CZ  . TYR   B 1 153 ? -28.70131 10.28556  -63.20385 1.000 17.66124 ? 153 TYR   B CZ  1 
ATOM   3145 O  OH  . TYR   B 1 153 ? -28.54774 8.96340   -62.78995 1.000 16.15897 ? 153 TYR   B OH  1 
ATOM   3146 N  N   . HIS   B 1 154 ? -27.01378 17.04932  -63.99471 1.000 32.49206 ? 154 HIS   B N   1 
ATOM   3147 C  CA  . HIS   B 1 154 ? -26.50225 18.36915  -64.35219 1.000 26.56522 ? 154 HIS   B CA  1 
ATOM   3148 C  C   . HIS   B 1 154 ? -26.37958 18.51141  -65.86605 1.000 27.48752 ? 154 HIS   B C   1 
ATOM   3149 O  O   . HIS   B 1 154 ? -25.73477 17.69212  -66.52383 1.000 23.86601 ? 154 HIS   B O   1 
ATOM   3150 C  CB  . HIS   B 1 154 ? -25.14447 18.60562  -63.69578 1.000 27.47144 ? 154 HIS   B CB  1 
ATOM   3151 C  CG  . HIS   B 1 154 ? -25.16015 18.52414  -62.19447 1.000 27.87981 ? 154 HIS   B CG  1 
ATOM   3152 N  ND1 . HIS   B 1 154 ? -24.10099 18.94958  -61.41940 1.000 26.31803 ? 154 HIS   B ND1 1 
ATOM   3153 C  CD2 . HIS   B 1 154 ? -26.09162 18.05422  -61.32936 1.000 27.49357 ? 154 HIS   B CD2 1 
ATOM   3154 C  CE1 . HIS   B 1 154 ? -24.38397 18.75611  -60.14225 1.000 27.11489 ? 154 HIS   B CE1 1 
ATOM   3155 N  NE2 . HIS   B 1 154 ? -25.58498 18.20942  -60.06012 1.000 28.29387 ? 154 HIS   B NE2 1 
ATOM   3156 N  N   . ALA   B 1 155 ? -26.98241 19.56568  -66.42068 1.000 28.88020 ? 155 ALA   B N   1 
ATOM   3157 C  CA  . ALA   B 1 155 ? -26.93855 19.75407  -67.86889 1.000 30.87348 ? 155 ALA   B CA  1 
ATOM   3158 C  C   . ALA   B 1 155 ? -25.60495 20.30986  -68.36238 1.000 33.42086 ? 155 ALA   B C   1 
ATOM   3159 O  O   . ALA   B 1 155 ? -25.25581 20.09836  -69.53164 1.000 35.71967 ? 155 ALA   B O   1 
ATOM   3160 C  CB  . ALA   B 1 155 ? -28.07415 20.66921  -68.32271 1.000 31.66793 ? 155 ALA   B CB  1 
ATOM   3161 N  N   . ASP   B 1 156 ? -24.84258 20.99071  -67.50741 1.000 28.61853 ? 156 ASP   B N   1 
ATOM   3162 C  CA  . ASP   B 1 156 ? -23.53627 21.50681  -67.89076 1.000 28.84023 ? 156 ASP   B CA  1 
ATOM   3163 C  C   . ASP   B 1 156 ? -22.42389 20.47486  -67.72807 1.000 30.92348 ? 156 ASP   B C   1 
ATOM   3164 O  O   . ASP   B 1 156 ? -21.24594 20.80615  -67.90323 1.000 28.00462 ? 156 ASP   B O   1 
ATOM   3165 C  CB  . ASP   B 1 156 ? -23.21293 22.75813  -67.08437 1.000 24.95757 ? 156 ASP   B CB  1 
ATOM   3166 C  CG  . ASP   B 1 156 ? -23.30331 22.52153  -65.60628 1.000 28.36818 ? 156 ASP   B CG  1 
ATOM   3167 O  OD1 . ASP   B 1 156 ? -24.03720 21.59463  -65.20981 1.000 30.41264 ? 156 ASP   B OD1 1 
ATOM   3168 O  OD2 . ASP   B 1 156 ? -22.63713 23.25097  -64.84308 1.000 29.48385 ? 156 ASP   B OD2 1 
ATOM   3169 N  N   . VAL   B 1 157 ? -22.76163 19.23054  -67.42534 1.000 29.21291 ? 157 VAL   B N   1 
ATOM   3170 C  CA  . VAL   B 1 157 ? -21.77432 18.16073  -67.34855 1.000 24.22106 ? 157 VAL   B CA  1 
ATOM   3171 C  C   . VAL   B 1 157 ? -21.83626 17.35575  -68.63472 1.000 20.55910 ? 157 VAL   B C   1 
ATOM   3172 O  O   . VAL   B 1 157 ? -22.91759 16.93110  -69.05758 1.000 27.49987 ? 157 VAL   B O   1 
ATOM   3173 C  CB  . VAL   B 1 157 ? -22.01415 17.28951  -66.10950 1.000 25.05227 ? 157 VAL   B CB  1 
ATOM   3174 C  CG1 . VAL   B 1 157 ? -21.14724 16.06596  -66.16247 1.000 22.25312 ? 157 VAL   B CG1 1 
ATOM   3175 C  CG2 . VAL   B 1 157 ? -21.71124 18.11934  -64.87419 1.000 15.87450 ? 157 VAL   B CG2 1 
ATOM   3176 N  N   . ALA   B 1 158 ? -20.67906 17.15418  -69.26897 1.000 19.99728 ? 158 ALA   B N   1 
ATOM   3177 C  CA  . ALA   B 1 158 ? -20.67825 16.68732  -70.65398 1.000 24.13349 ? 158 ALA   B CA  1 
ATOM   3178 C  C   . ALA   B 1 158 ? -21.06647 15.21693  -70.76951 1.000 22.88803 ? 158 ALA   B C   1 
ATOM   3179 O  O   . ALA   B 1 158 ? -21.73440 14.82711  -71.73358 1.000 19.86661 ? 158 ALA   B O   1 
ATOM   3180 C  CB  . ALA   B 1 158 ? -19.30871 16.93271  -71.29998 1.000 25.14006 ? 158 ALA   B CB  1 
ATOM   3181 N  N   . TYR   B 1 159 ? -20.65049 14.37428  -69.82010 1.000 23.29269 ? 159 TYR   B N   1 
ATOM   3182 C  CA  . TYR   B 1 159 ? -20.91951 12.94149  -69.90763 1.000 16.48679 ? 159 TYR   B CA  1 
ATOM   3183 C  C   . TYR   B 1 159 ? -21.93032 12.46973  -68.86757 1.000 18.51530 ? 159 TYR   B C   1 
ATOM   3184 O  O   . TYR   B 1 159 ? -23.01191 12.00753  -69.22471 1.000 16.61511 ? 159 TYR   B O   1 
ATOM   3185 C  CB  . TYR   B 1 159 ? -19.61921 12.15527  -69.78579 1.000 16.20560 ? 159 TYR   B CB  1 
ATOM   3186 C  CG  . TYR   B 1 159 ? -19.84817 10.68337  -69.94235 1.000 17.48548 ? 159 TYR   B CG  1 
ATOM   3187 C  CD1 . TYR   B 1 159 ? -19.83268 10.08885  -71.20257 1.000 17.65743 ? 159 TYR   B CD1 1 
ATOM   3188 C  CD2 . TYR   B 1 159 ? -20.10550 9.88475   -68.83383 1.000 15.99803 ? 159 TYR   B CD2 1 
ATOM   3189 C  CE1 . TYR   B 1 159 ? -20.05773 8.73241   -71.34921 1.000 18.88362 ? 159 TYR   B CE1 1 
ATOM   3190 C  CE2 . TYR   B 1 159 ? -20.33446 8.53369   -68.96870 1.000 16.03136 ? 159 TYR   B CE2 1 
ATOM   3191 C  CZ  . TYR   B 1 159 ? -20.32546 7.96355   -70.22510 1.000 16.57077 ? 159 TYR   B CZ  1 
ATOM   3192 O  OH  . TYR   B 1 159 ? -20.53893 6.61472   -70.33360 1.000 15.09841 ? 159 TYR   B OH  1 
ATOM   3193 N  N   . HIS   B 1 160 ? -21.58376 12.51885  -67.57922 1.000 22.21036 ? 160 HIS   B N   1 
ATOM   3194 C  CA  . HIS   B 1 160 ? -22.45506 12.01779  -66.52282 1.000 14.82337 ? 160 HIS   B CA  1 
ATOM   3195 C  C   . HIS   B 1 160 ? -23.67837 12.89883  -66.32609 1.000 16.73000 ? 160 HIS   B C   1 
ATOM   3196 O  O   . HIS   B 1 160 ? -23.77455 13.63324  -65.34162 1.000 17.04926 ? 160 HIS   B O   1 
ATOM   3197 C  CB  . HIS   B 1 160 ? -21.66631 11.89190  -65.22376 1.000 14.04480 ? 160 HIS   B CB  1 
ATOM   3198 C  CG  . HIS   B 1 160 ? -20.62099 10.83000  -65.27638 1.000 14.00226 ? 160 HIS   B CG  1 
ATOM   3199 N  ND1 . HIS   B 1 160 ? -19.28299 11.10792  -65.46768 1.000 13.78867 ? 160 HIS   B ND1 1 
ATOM   3200 C  CD2 . HIS   B 1 160 ? -20.72126 9.48093   -65.21494 1.000 11.08623 ? 160 HIS   B CD2 1 
ATOM   3201 C  CE1 . HIS   B 1 160 ? -18.59977 9.97644   -65.49364 1.000 11.50540 ? 160 HIS   B CE1 1 
ATOM   3202 N  NE2 . HIS   B 1 160 ? -19.44753 8.97506   -65.34258 1.000 13.48856 ? 160 HIS   B NE2 1 
ATOM   3203 N  N   . ASN   B 1 161 ? -24.62438 12.80899  -67.25366 1.000 15.24183 ? 161 ASN   B N   1 
ATOM   3204 C  CA  . ASN   B 1 161 ? -25.83046 13.62733  -67.23468 1.000 22.32321 ? 161 ASN   B CA  1 
ATOM   3205 C  C   . ASN   B 1 161 ? -27.02643 12.72419  -67.50698 1.000 16.92435 ? 161 ASN   B C   1 
ATOM   3206 O  O   . ASN   B 1 161 ? -26.88586 11.50001  -67.50200 1.000 20.32354 ? 161 ASN   B O   1 
ATOM   3207 C  CB  . ASN   B 1 161 ? -25.74530 14.74130  -68.28657 1.000 21.83814 ? 161 ASN   B CB  1 
ATOM   3208 C  CG  . ASN   B 1 161 ? -25.41327 14.19569  -69.67416 1.000 22.17380 ? 161 ASN   B CG  1 
ATOM   3209 O  OD1 . ASN   B 1 161 ? -26.07571 13.28356  -70.17409 1.000 24.35389 ? 161 ASN   B OD1 1 
ATOM   3210 N  ND2 . ASN   B 1 161 ? -24.36848 14.73045  -70.28301 1.000 23.60824 ? 161 ASN   B ND2 1 
ATOM   3211 N  N   . ASN   B 1 162 ? -28.18360 13.31268  -67.80342 1.000 20.22771 ? 162 ASN   B N   1 
ATOM   3212 C  CA  . ASN   B 1 162 ? -29.40384 12.52594  -67.98406 1.000 18.81295 ? 162 ASN   B CA  1 
ATOM   3213 C  C   . ASN   B 1 162 ? -29.37123 11.65902  -69.24159 1.000 22.31844 ? 162 ASN   B C   1 
ATOM   3214 O  O   . ASN   B 1 162 ? -30.01875 10.60337  -69.27785 1.000 28.60397 ? 162 ASN   B O   1 
ATOM   3215 C  CB  . ASN   B 1 162 ? -30.62615 13.45331  -67.98291 1.000 25.39346 ? 162 ASN   B CB  1 
ATOM   3216 C  CG  . ASN   B 1 162 ? -30.50239 14.61604  -68.96545 1.000 24.61149 ? 162 ASN   B CG  1 
ATOM   3217 O  OD1 . ASN   B 1 162 ? -29.41950 14.91104  -69.47425 1.000 24.28748 ? 162 ASN   B OD1 1 
ATOM   3218 N  ND2 . ASN   B 1 162 ? -31.62114 15.28820  -69.22273 1.000 30.22799 ? 162 ASN   B ND2 1 
ATOM   3219 N  N   . ILE   B 1 163 ? -28.64045 12.06692  -70.28219 1.000 24.94751 ? 163 ILE   B N   1 
ATOM   3220 C  CA  . ILE   B 1 163 ? -28.47811 11.18342  -71.43562 1.000 24.87687 ? 163 ILE   B CA  1 
ATOM   3221 C  C   . ILE   B 1 163 ? -27.75034 9.90708   -71.03205 1.000 21.51989 ? 163 ILE   B C   1 
ATOM   3222 O  O   . ILE   B 1 163 ? -28.10581 8.80749   -71.47635 1.000 27.84896 ? 163 ILE   B O   1 
ATOM   3223 C  CB  . ILE   B 1 163 ? -27.74284 11.89901  -72.59160 1.000 27.46694 ? 163 ILE   B CB  1 
ATOM   3224 C  CG1 . ILE   B 1 163 ? -28.36189 13.25572  -72.90852 1.000 22.75080 ? 163 ILE   B CG1 1 
ATOM   3225 C  CG2 . ILE   B 1 163 ? -27.79094 11.07250  -73.83720 1.000 18.27864 ? 163 ILE   B CG2 1 
ATOM   3226 C  CD1 . ILE   B 1 163 ? -27.59009 13.99079  -73.99146 1.000 24.20286 ? 163 ILE   B CD1 1 
ATOM   3227 N  N   . HIS   B 1 164 ? -26.70088 10.02399  -70.21212 1.000 19.77349 ? 164 HIS   B N   1 
ATOM   3228 C  CA  . HIS   B 1 164 ? -25.98698 8.81808   -69.79218 1.000 21.85234 ? 164 HIS   B CA  1 
ATOM   3229 C  C   . HIS   B 1 164 ? -26.89830 7.92530   -68.95596 1.000 18.37991 ? 164 HIS   B C   1 
ATOM   3230 O  O   . HIS   B 1 164 ? -26.89274 6.69944   -69.10682 1.000 19.58971 ? 164 HIS   B O   1 
ATOM   3231 C  CB  . HIS   B 1 164 ? -24.71205 9.19197   -69.02046 1.000 14.92619 ? 164 HIS   B CB  1 
ATOM   3232 C  CG  . HIS   B 1 164 ? -24.06689 8.05026   -68.28667 1.000 15.31528 ? 164 HIS   B CG  1 
ATOM   3233 N  ND1 . HIS   B 1 164 ? -23.63295 6.89972   -68.91017 1.000 17.09289 ? 164 HIS   B ND1 1 
ATOM   3234 C  CD2 . HIS   B 1 164 ? -23.78043 7.89102   -66.97170 1.000 13.48201 ? 164 HIS   B CD2 1 
ATOM   3235 C  CE1 . HIS   B 1 164 ? -23.09489 6.09248   -68.01625 1.000 12.68118 ? 164 HIS   B CE1 1 
ATOM   3236 N  NE2 . HIS   B 1 164 ? -23.17024 6.67265   -66.83251 1.000 16.28761 ? 164 HIS   B NE2 1 
ATOM   3237 N  N   . ALA   B 1 165 ? -27.67715 8.53448   -68.06800 1.000 18.04299 ? 165 ALA   B N   1 
ATOM   3238 C  CA  . ALA   B 1 165 ? -28.64412 7.80308   -67.26536 1.000 18.48735 ? 165 ALA   B CA  1 
ATOM   3239 C  C   . ALA   B 1 165 ? -29.65616 7.09628   -68.15786 1.000 23.99220 ? 165 ALA   B C   1 
ATOM   3240 O  O   . ALA   B 1 165 ? -29.82423 5.86920   -68.08826 1.000 23.97142 ? 165 ALA   B O   1 
ATOM   3241 C  CB  . ALA   B 1 165 ? -29.32588 8.77662   -66.30760 1.000 15.42358 ? 165 ALA   B CB  1 
ATOM   3242 N  N   . ALA   B 1 166 ? -30.32627 7.86680   -69.02794 1.000 30.16751 ? 166 ALA   B N   1 
ATOM   3243 C  CA  . ALA   B 1 166 ? -31.25458 7.29340   -70.00166 1.000 31.17395 ? 166 ALA   B CA  1 
ATOM   3244 C  C   . ALA   B 1 166 ? -30.63317 6.10876   -70.72909 1.000 25.88047 ? 166 ALA   B C   1 
ATOM   3245 O  O   . ALA   B 1 166 ? -31.29829 5.09047   -70.96673 1.000 24.62437 ? 166 ALA   B O   1 
ATOM   3246 C  CB  . ALA   B 1 166 ? -31.68635 8.37090   -71.00746 1.000 31.56834 ? 166 ALA   B CB  1 
ATOM   3247 N  N   . ASP   B 1 167 ? -29.34024 6.21688   -71.05699 1.000 27.09459 ? 167 ASP   B N   1 
ATOM   3248 C  CA  . ASP   B 1 167 ? -28.65220 5.18218   -71.81804 1.000 19.83642 ? 167 ASP   B CA  1 
ATOM   3249 C  C   . ASP   B 1 167 ? -28.31649 3.96507   -70.96795 1.000 26.92881 ? 167 ASP   B C   1 
ATOM   3250 O  O   . ASP   B 1 167 ? -28.20273 2.84517   -71.49907 1.000 20.49143 ? 167 ASP   B O   1 
ATOM   3251 C  CB  . ASP   B 1 167 ? -27.37332 5.76218   -72.42525 1.000 26.70614 ? 167 ASP   B CB  1 
ATOM   3252 C  CG  . ASP   B 1 167 ? -26.55844 4.72427   -73.15156 1.000 22.42635 ? 167 ASP   B CG  1 
ATOM   3253 O  OD1 . ASP   B 1 167 ? -27.14331 4.01927   -73.98821 1.000 28.59624 ? 167 ASP   B OD1 1 
ATOM   3254 O  OD2 . ASP   B 1 167 ? -25.34440 4.58586   -72.86787 1.000 29.54148 ? 167 ASP   B OD2 1 
ATOM   3255 N  N   . VAL   B 1 168 ? -28.09051 4.15482   -69.66499 1.000 22.91966 ? 168 VAL   B N   1 
ATOM   3256 C  CA  . VAL   B 1 168 ? -27.79004 2.98181   -68.84837 1.000 25.69571 ? 168 VAL   B CA  1 
ATOM   3257 C  C   . VAL   B 1 168 ? -29.08090 2.22444   -68.53357 1.000 22.65993 ? 168 VAL   B C   1 
ATOM   3258 O  O   . VAL   B 1 168 ? -29.13714 0.99179   -68.62659 1.000 25.22088 ? 168 VAL   B O   1 
ATOM   3259 C  CB  . VAL   B 1 168 ? -27.00788 3.39465   -67.58274 1.000 26.48133 ? 168 VAL   B CB  1 
ATOM   3260 C  CG1 . VAL   B 1 168 ? -26.85027 2.20196   -66.58630 1.000 20.46137 ? 168 VAL   B CG1 1 
ATOM   3261 C  CG2 . VAL   B 1 168 ? -25.63938 3.91835   -67.98128 1.000 16.60803 ? 168 VAL   B CG2 1 
ATOM   3262 N  N   . VAL   B 1 169 ? -30.13412 2.95956   -68.19762 1.000 26.74305 ? 169 VAL   B N   1 
ATOM   3263 C  CA  . VAL   B 1 169 ? -31.48444 2.43706   -68.07533 1.000 28.27572 ? 169 VAL   B CA  1 
ATOM   3264 C  C   . VAL   B 1 169 ? -31.76521 1.47160   -69.21589 1.000 33.57399 ? 169 VAL   B C   1 
ATOM   3265 O  O   . VAL   B 1 169 ? -31.94580 0.26612   -68.99906 1.000 36.01925 ? 169 VAL   B O   1 
ATOM   3266 C  CB  . VAL   B 1 169 ? -32.48484 3.59943   -68.07192 1.000 28.79817 ? 169 VAL   B CB  1 
ATOM   3267 C  CG1 . VAL   B 1 169 ? -33.86358 3.13196   -68.49694 1.000 38.81359 ? 169 VAL   B CG1 1 
ATOM   3268 C  CG2 . VAL   B 1 169 ? -32.52464 4.23710   -66.70479 1.000 30.34635 ? 169 VAL   B CG2 1 
ATOM   3269 N  N   . GLN   B 1 170 ? -31.72417 1.99137   -70.44395 1.000 33.57183 ? 170 GLN   B N   1 
ATOM   3270 C  CA  . GLN   B 1 170 ? -32.16025 1.22258   -71.59869 1.000 26.45841 ? 170 GLN   B CA  1 
ATOM   3271 C  C   . GLN   B 1 170 ? -31.21957 0.06346   -71.87352 1.000 33.79146 ? 170 GLN   B C   1 
ATOM   3272 O  O   . GLN   B 1 170 ? -31.66366 -1.01461  -72.29434 1.000 32.10095 ? 170 GLN   B O   1 
ATOM   3273 C  CB  . GLN   B 1 170 ? -32.30025 2.15196   -72.81383 1.000 42.30537 ? 170 GLN   B CB  1 
ATOM   3274 C  CG  . GLN   B 1 170 ? -32.69311 1.46677   -74.13323 1.000 37.71037 ? 170 GLN   B CG  1 
ATOM   3275 C  CD  . GLN   B 1 170 ? -31.49610 0.86885   -74.83974 1.000 38.79996 ? 170 GLN   B CD  1 
ATOM   3276 O  OE1 . GLN   B 1 170 ? -30.42599 1.48367   -74.89449 1.000 43.97264 ? 170 GLN   B OE1 1 
ATOM   3277 N  NE2 . GLN   B 1 170 ? -31.65276 -0.35141  -75.34914 1.000 34.87637 ? 170 GLN   B NE2 1 
ATOM   3278 N  N   . SER   B 1 171 ? -29.91514 0.25516   -71.64037 1.000 30.10869 ? 171 SER   B N   1 
ATOM   3279 C  CA  . SER   B 1 171 ? -28.97482 -0.83082  -71.89697 1.000 24.89394 ? 171 SER   B CA  1 
ATOM   3280 C  C   . SER   B 1 171 ? -29.09524 -1.92903  -70.85307 1.000 32.38252 ? 171 SER   B C   1 
ATOM   3281 O  O   . SER   B 1 171 ? -28.88830 -3.10549  -71.16348 1.000 30.96530 ? 171 SER   B O   1 
ATOM   3282 C  CB  . SER   B 1 171 ? -27.53580 -0.30982  -71.93260 1.000 32.14525 ? 171 SER   B CB  1 
ATOM   3283 O  OG  . SER   B 1 171 ? -27.39173 0.78984   -72.81762 1.000 37.62514 ? 171 SER   B OG  1 
ATOM   3284 N  N   . THR   B 1 172 ? -29.38036 -1.55203  -69.60706 1.000 34.44282 ? 172 THR   B N   1 
ATOM   3285 C  CA  . THR   B 1 172 ? -29.76229 -2.53026  -68.59764 1.000 37.11929 ? 172 THR   B CA  1 
ATOM   3286 C  C   . THR   B 1 172 ? -31.02593 -3.27000  -69.02565 1.000 33.48215 ? 172 THR   B C   1 
ATOM   3287 O  O   . THR   B 1 172 ? -31.07079 -4.50565  -69.03940 1.000 31.34642 ? 172 THR   B O   1 
ATOM   3288 C  CB  . THR   B 1 172 ? -29.96358 -1.81617  -67.25513 1.000 31.30475 ? 172 THR   B CB  1 
ATOM   3289 O  OG1 . THR   B 1 172 ? -28.68075 -1.48760  -66.67492 1.000 22.75443 ? 172 THR   B OG1 1 
ATOM   3290 C  CG2 . THR   B 1 172 ? -30.78383 -2.67391  -66.30312 1.000 30.34072 ? 172 THR   B CG2 1 
ATOM   3291 N  N   . HIS   B 1 173 ? -32.04942 -2.51420  -69.42502 1.000 37.47677 ? 173 HIS   B N   1 
ATOM   3292 C  CA  . HIS   B 1 173 ? -33.31042 -3.07966  -69.88851 1.000 41.30019 ? 173 HIS   B CA  1 
ATOM   3293 C  C   . HIS   B 1 173 ? -33.14253 -4.15072  -70.95888 1.000 42.29164 ? 173 HIS   B C   1 
ATOM   3294 O  O   . HIS   B 1 173 ? -34.04408 -4.97184  -71.14433 1.000 46.63513 ? 173 HIS   B O   1 
ATOM   3295 C  CB  . HIS   B 1 173 ? -34.19661 -1.95763  -70.42329 1.000 38.93190 ? 173 HIS   B CB  1 
ATOM   3296 C  CG  . HIS   B 1 173 ? -35.24571 -2.42452  -71.38195 1.000 53.36157 ? 173 HIS   B CG  1 
ATOM   3297 N  ND1 . HIS   B 1 173 ? -36.35460 -3.13586  -70.97544 1.000 55.87814 ? 173 HIS   B ND1 1 
ATOM   3298 C  CD2 . HIS   B 1 173 ? -35.37530 -2.26041  -72.71935 1.000 52.09712 ? 173 HIS   B CD2 1 
ATOM   3299 C  CE1 . HIS   B 1 173 ? -37.12449 -3.38584  -72.01826 1.000 55.72538 ? 173 HIS   B CE1 1 
ATOM   3300 N  NE2 . HIS   B 1 173 ? -36.54894 -2.87248  -73.09042 1.000 54.02880 ? 173 HIS   B NE2 1 
ATOM   3301 N  N   . VAL   B 1 174 ? -32.02402 -4.16285  -71.67130 1.000 37.38551 ? 174 VAL   B N   1 
ATOM   3302 C  CA  . VAL   B 1 174 ? -31.77983 -5.14124  -72.71562 1.000 35.83609 ? 174 VAL   B CA  1 
ATOM   3303 C  C   . VAL   B 1 174 ? -31.04688 -6.35404  -72.17081 1.000 40.82474 ? 174 VAL   B C   1 
ATOM   3304 O  O   . VAL   B 1 174 ? -31.40819 -7.49425  -72.46599 1.000 40.25497 ? 174 VAL   B O   1 
ATOM   3305 C  CB  . VAL   B 1 174 ? -31.01143 -4.48609  -73.88768 1.000 35.15214 ? 174 VAL   B CB  1 
ATOM   3306 C  CG1 . VAL   B 1 174 ? -30.38070 -5.53926  -74.78643 1.000 35.54343 ? 174 VAL   B CG1 1 
ATOM   3307 C  CG2 . VAL   B 1 174 ? -31.94407 -3.59755  -74.68431 1.000 36.08355 ? 174 VAL   B CG2 1 
ATOM   3308 N  N   . LEU   B 1 175 ? -30.01347 -6.12759  -71.35880 1.000 33.18897 ? 175 LEU   B N   1 
ATOM   3309 C  CA  . LEU   B 1 175 ? -29.35875 -7.23977  -70.69514 1.000 33.28837 ? 175 LEU   B CA  1 
ATOM   3310 C  C   . LEU   B 1 175 ? -30.32161 -8.03366  -69.82421 1.000 44.61602 ? 175 LEU   B C   1 
ATOM   3311 O  O   . LEU   B 1 175 ? -29.98893 -9.15383  -69.42177 1.000 46.46317 ? 175 LEU   B O   1 
ATOM   3312 C  CB  . LEU   B 1 175 ? -28.19494 -6.73265  -69.85312 1.000 34.11547 ? 175 LEU   B CB  1 
ATOM   3313 C  CG  . LEU   B 1 175 ? -27.10993 -5.93955  -70.59155 1.000 37.60920 ? 175 LEU   B CG  1 
ATOM   3314 C  CD1 . LEU   B 1 175 ? -26.14894 -5.27096  -69.60769 1.000 26.74337 ? 175 LEU   B CD1 1 
ATOM   3315 C  CD2 . LEU   B 1 175 ? -26.34959 -6.86128  -71.52345 1.000 36.07669 ? 175 LEU   B CD2 1 
ATOM   3316 N  N   . LEU   B 1 176 ? -31.49879 -7.48133  -69.52357 1.000 41.88902 ? 176 LEU   B N   1 
ATOM   3317 C  CA  . LEU   B 1 176 ? -32.48522 -8.20634  -68.73546 1.000 47.97130 ? 176 LEU   B CA  1 
ATOM   3318 C  C   . LEU   B 1 176 ? -33.23344 -9.20717  -69.61040 1.000 51.14667 ? 176 LEU   B C   1 
ATOM   3319 O  O   . LEU   B 1 176 ? -33.21496 -10.41470 -69.34263 1.000 46.79279 ? 176 LEU   B O   1 
ATOM   3320 C  CB  . LEU   B 1 176 ? -33.44203 -7.21512  -68.05048 1.000 40.78622 ? 176 LEU   B CB  1 
ATOM   3321 C  CG  . LEU   B 1 176 ? -32.83246 -6.56762  -66.79531 1.000 38.05590 ? 176 LEU   B CG  1 
ATOM   3322 C  CD1 . LEU   B 1 176 ? -33.78112 -5.58164  -66.13288 1.000 28.79356 ? 176 LEU   B CD1 1 
ATOM   3323 C  CD2 . LEU   B 1 176 ? -32.38967 -7.63639  -65.80245 1.000 30.76253 ? 176 LEU   B CD2 1 
ATOM   3324 N  N   . SER   B 1 177 ? -33.86545 -8.71977  -70.68702 1.000 47.28972 ? 177 SER   B N   1 
ATOM   3325 C  CA  . SER   B 1 177 ? -34.67526 -9.55630  -71.56917 1.000 53.80479 ? 177 SER   B CA  1 
ATOM   3326 C  C   . SER   B 1 177 ? -33.85185 -10.22758 -72.66497 1.000 45.84467 ? 177 SER   B C   1 
ATOM   3327 O  O   . SER   B 1 177 ? -34.29070 -10.31973 -73.80776 1.000 53.70763 ? 177 SER   B O   1 
ATOM   3328 C  CB  . SER   B 1 177 ? -35.80599 -8.72639  -72.16868 1.000 51.40772 ? 177 SER   B CB  1 
ATOM   3329 O  OG  . SER   B 1 177 ? -35.28753 -7.63815  -72.90551 1.000 55.10358 ? 177 SER   B OG  1 
ATOM   3330 N  N   . THR   B 1 178 ? -32.62537 -10.67985 -72.34424 1.000 40.49248 ? 178 THR   B N   1 
ATOM   3331 C  CA  . THR   B 1 178 ? -32.00242 -11.80598 -73.02003 1.000 51.16276 ? 178 THR   B CA  1 
ATOM   3332 C  C   . THR   B 1 178 ? -32.54153 -13.11774 -72.42444 1.000 59.67549 ? 178 THR   B C   1 
ATOM   3333 O  O   . THR   B 1 178 ? -32.83004 -13.20575 -71.23002 1.000 64.77010 ? 178 THR   B O   1 
ATOM   3334 C  CB  . THR   B 1 178 ? -30.48012 -11.72147 -72.91132 1.000 49.64603 ? 178 THR   B CB  1 
ATOM   3335 O  OG1 . THR   B 1 178 ? -29.88489 -12.92089 -73.38152 1.000 53.74131 ? 178 THR   B OG1 1 
ATOM   3336 C  CG2 . THR   B 1 178 ? -30.06720 -11.55267 -71.47513 1.000 47.81396 ? 178 THR   B CG2 1 
ATOM   3337 N  N   . PRO   B 1 179 ? -32.80021 -14.12329 -73.26977 1.000 60.90641 ? 179 PRO   B N   1 
ATOM   3338 C  CA  . PRO   B 1 179 ? -33.41745 -15.37944 -72.76931 1.000 59.77627 ? 179 PRO   B CA  1 
ATOM   3339 C  C   . PRO   B 1 179 ? -32.56489 -16.26904 -71.87158 1.000 61.56274 ? 179 PRO   B C   1 
ATOM   3340 O  O   . PRO   B 1 179 ? -33.11437 -16.97823 -71.01186 1.000 69.02067 ? 179 PRO   B O   1 
ATOM   3341 C  CB  . PRO   B 1 179 ? -33.84214 -16.08741 -74.08574 1.000 62.45714 ? 179 PRO   B CB  1 
ATOM   3342 C  CG  . PRO   B 1 179 ? -32.83235 -15.64300 -75.08694 1.000 58.67806 ? 179 PRO   B CG  1 
ATOM   3343 C  CD  . PRO   B 1 179 ? -32.84388 -14.12171 -74.73642 1.000 61.61888 ? 179 PRO   B CD  1 
ATOM   3344 N  N   . ALA   B 1 180 ? -31.26055 -16.26055 -72.04780 1.000 54.80528 ? 180 ALA   B N   1 
ATOM   3345 C  CA  . ALA   B 1 180 ? -30.40021 -16.83607 -71.03810 1.000 58.81518 ? 180 ALA   B CA  1 
ATOM   3346 C  C   . ALA   B 1 180 ? -30.64236 -16.23224 -69.65904 1.000 62.27579 ? 180 ALA   B C   1 
ATOM   3347 O  O   . ALA   B 1 180 ? -30.21277 -16.81259 -68.65119 1.000 64.16561 ? 180 ALA   B O   1 
ATOM   3348 C  CB  . ALA   B 1 180 ? -28.93658 -16.63663 -71.44048 1.000 54.24994 ? 180 ALA   B CB  1 
ATOM   3349 N  N   . LEU   B 1 181 ? -31.28058 -15.06555 -69.60615 1.000 63.48278 ? 181 LEU   B N   1 
ATOM   3350 C  CA  . LEU   B 1 181 ? -31.84949 -14.49171 -68.39709 1.000 65.25583 ? 181 LEU   B CA  1 
ATOM   3351 C  C   . LEU   B 1 181 ? -33.34859 -14.31038 -68.60103 1.000 66.29397 ? 181 LEU   B C   1 
ATOM   3352 O  O   . LEU   B 1 181 ? -33.85133 -13.18217 -68.57843 1.000 60.75485 ? 181 LEU   B O   1 
ATOM   3353 C  CB  . LEU   B 1 181 ? -31.19170 -13.14834 -68.06396 1.000 56.50027 ? 181 LEU   B CB  1 
ATOM   3354 C  CG  . LEU   B 1 181 ? -29.66525 -13.18161 -67.98294 1.000 60.56195 ? 181 LEU   B CG  1 
ATOM   3355 C  CD1 . LEU   B 1 181 ? -29.12062 -11.81689 -67.57901 1.000 55.10143 ? 181 LEU   B CD1 1 
ATOM   3356 C  CD2 . LEU   B 1 181 ? -29.19625 -14.27511 -67.02530 1.000 56.73094 ? 181 LEU   B CD2 1 
ATOM   3357 N  N   . GLU   B 1 182 ? -34.06272 -15.40535 -68.85467 1.000 69.32000 ? 182 GLU   B N   1 
ATOM   3358 C  CA  . GLU   B 1 182 ? -35.51289 -15.36226 -69.05448 1.000 74.41765 ? 182 GLU   B CA  1 
ATOM   3359 C  C   . GLU   B 1 182 ? -36.18876 -15.28067 -67.69368 1.000 67.91642 ? 182 GLU   B C   1 
ATOM   3360 O  O   . GLU   B 1 182 ? -36.37977 -16.30099 -67.02784 1.000 68.55772 ? 182 GLU   B O   1 
ATOM   3361 C  CB  . GLU   B 1 182 ? -35.98711 -16.59769 -69.80842 1.000 71.49322 ? 182 GLU   B CB  1 
ATOM   3362 C  CG  . GLU   B 1 182 ? -36.72984 -16.33973 -71.09478 1.000 68.00098 ? 182 GLU   B CG  1 
ATOM   3363 C  CD  . GLU   B 1 182 ? -37.28003 -17.62452 -71.66667 1.000 67.90314 ? 182 GLU   B CD  1 
ATOM   3364 O  OE1 . GLU   B 1 182 ? -38.49793 -17.86383 -71.51047 1.000 73.85606 ? 182 GLU   B OE1 1 
ATOM   3365 O  OE2 . GLU   B 1 182 ? -36.48677 -18.40853 -72.23718 1.000 62.14634 ? 182 GLU   B OE2 1 
ATOM   3366 N  N   . ALA   B 1 183 ? -36.55932 -14.06979 -67.28223 1.000 63.71723 ? 183 ALA   B N   1 
ATOM   3367 C  CA  . ALA   B 1 183 ? -37.18187 -13.82453 -65.97832 1.000 67.09242 ? 183 ALA   B CA  1 
ATOM   3368 C  C   . ALA   B 1 183 ? -36.53724 -14.67378 -64.88011 1.000 61.06861 ? 183 ALA   B C   1 
ATOM   3369 O  O   . ALA   B 1 183 ? -37.20705 -15.34499 -64.09191 1.000 57.82475 ? 183 ALA   B O   1 
ATOM   3370 C  CB  . ALA   B 1 183 ? -38.69160 -14.05308 -66.03888 1.000 65.93365 ? 183 ALA   B CB  1 
ATOM   3371 N  N   . VAL   B 1 184 ? -35.20187 -14.64678 -64.84845 1.000 68.05076 ? 184 VAL   B N   1 
ATOM   3372 C  CA  . VAL   B 1 184 ? -34.41304 -15.21761 -63.75732 1.000 65.92815 ? 184 VAL   B CA  1 
ATOM   3373 C  C   . VAL   B 1 184 ? -34.45918 -14.21845 -62.60130 1.000 60.36858 ? 184 VAL   B C   1 
ATOM   3374 O  O   . VAL   B 1 184 ? -33.77265 -14.37490 -61.58385 1.000 54.21510 ? 184 VAL   B O   1 
ATOM   3375 C  CB  . VAL   B 1 184 ? -32.96751 -15.51804 -64.21662 1.000 57.43362 ? 184 VAL   B CB  1 
ATOM   3376 C  CG1 . VAL   B 1 184 ? -32.14851 -16.22503 -63.12598 1.000 57.02696 ? 184 VAL   B CG1 1 
ATOM   3377 C  CG2 . VAL   B 1 184 ? -32.97716 -16.34671 -65.49295 1.000 57.12321 ? 184 VAL   B CG2 1 
ATOM   3378 N  N   . PHE   B 1 185 ? -35.29801 -13.19494 -62.75151 1.000 47.91233 ? 185 PHE   B N   1 
ATOM   3379 C  CA  . PHE   B 1 185 ? -35.35993 -12.05207 -61.85699 1.000 52.37887 ? 185 PHE   B CA  1 
ATOM   3380 C  C   . PHE   B 1 185 ? -36.82402 -11.63525 -61.76550 1.000 50.40659 ? 185 PHE   B C   1 
ATOM   3381 O  O   . PHE   B 1 185 ? -37.55273 -11.72922 -62.75795 1.000 45.99139 ? 185 PHE   B O   1 
ATOM   3382 C  CB  . PHE   B 1 185 ? -34.49626 -10.88904 -62.38412 1.000 43.88897 ? 185 PHE   B CB  1 
ATOM   3383 C  CG  . PHE   B 1 185 ? -33.02077 -11.19339 -62.49919 1.000 40.94743 ? 185 PHE   B CG  1 
ATOM   3384 C  CD1 . PHE   B 1 185 ? -32.22671 -11.29086 -61.36753 1.000 41.84244 ? 185 PHE   B CD1 1 
ATOM   3385 C  CD2 . PHE   B 1 185 ? -32.41622 -11.32086 -63.74428 1.000 42.59249 ? 185 PHE   B CD2 1 
ATOM   3386 C  CE1 . PHE   B 1 185 ? -30.86764 -11.54232 -61.47353 1.000 40.32019 ? 185 PHE   B CE1 1 
ATOM   3387 C  CE2 . PHE   B 1 185 ? -31.05783 -11.57569 -63.85323 1.000 36.75287 ? 185 PHE   B CE2 1 
ATOM   3388 C  CZ  . PHE   B 1 185 ? -30.28255 -11.68945 -62.71123 1.000 38.78806 ? 185 PHE   B CZ  1 
ATOM   3389 N  N   . THR   B 1 186 ? -37.25277 -11.16808 -60.59280 1.000 39.09628 ? 186 THR   B N   1 
ATOM   3390 C  CA  . THR   B 1 186 ? -38.67705 -10.95057 -60.36765 1.000 42.06711 ? 186 THR   B CA  1 
ATOM   3391 C  C   . THR   B 1 186 ? -39.09679 -9.55330  -60.81876 1.000 41.96114 ? 186 THR   B C   1 
ATOM   3392 O  O   . THR   B 1 186 ? -38.26877 -8.66210  -61.01450 1.000 47.28826 ? 186 THR   B O   1 
ATOM   3393 C  CB  . THR   B 1 186 ? -39.03247 -11.16406 -58.89095 1.000 48.08388 ? 186 THR   B CB  1 
ATOM   3394 O  OG1 . THR   B 1 186 ? -40.45475 -11.23481 -58.73817 1.000 54.81982 ? 186 THR   B OG1 1 
ATOM   3395 C  CG2 . THR   B 1 186 ? -38.52862 -10.02998 -58.04306 1.000 37.04531 ? 186 THR   B CG2 1 
ATOM   3396 N  N   . ASP   B 1 187 ? -40.41062 -9.36402  -60.98028 1.000 40.46856 ? 187 ASP   B N   1 
ATOM   3397 C  CA  . ASP   B 1 187 ? -40.91517 -8.03963  -61.33615 1.000 47.87678 ? 187 ASP   B CA  1 
ATOM   3398 C  C   . ASP   B 1 187 ? -40.44200 -6.96041  -60.36200 1.000 48.21148 ? 187 ASP   B C   1 
ATOM   3399 O  O   . ASP   B 1 187 ? -40.50039 -5.77089  -60.69114 1.000 47.64328 ? 187 ASP   B O   1 
ATOM   3400 C  CB  . ASP   B 1 187 ? -42.45031 -8.05154  -61.42148 1.000 56.61201 ? 187 ASP   B CB  1 
ATOM   3401 C  CG  . ASP   B 1 187 ? -42.96931 -8.68016  -62.71893 1.000 61.09421 ? 187 ASP   B CG  1 
ATOM   3402 O  OD1 . ASP   B 1 187 ? -43.15629 -7.94388  -63.71662 1.000 56.09901 ? 187 ASP   B OD1 1 
ATOM   3403 O  OD2 . ASP   B 1 187 ? -43.19132 -9.90965  -62.73937 1.000 61.87060 ? 187 ASP   B OD2 1 
ATOM   3404 N  N   . LEU   B 1 188 ? -39.96283 -7.34922  -59.18006 1.000 43.59385 ? 188 LEU   B N   1 
ATOM   3405 C  CA  . LEU   B 1 188 ? -39.30764 -6.45990  -58.22557 1.000 46.35769 ? 188 LEU   B CA  1 
ATOM   3406 C  C   . LEU   B 1 188 ? -37.81393 -6.28927  -58.52171 1.000 42.38837 ? 188 LEU   B C   1 
ATOM   3407 O  O   . LEU   B 1 188 ? -37.29324 -5.17076  -58.45863 1.000 34.12681 ? 188 LEU   B O   1 
ATOM   3408 C  CB  . LEU   B 1 188 ? -39.50325 -7.00547  -56.80535 1.000 36.72879 ? 188 LEU   B CB  1 
ATOM   3409 C  CG  . LEU   B 1 188 ? -38.94928 -6.28357  -55.57916 1.000 37.61319 ? 188 LEU   B CG  1 
ATOM   3410 C  CD1 . LEU   B 1 188 ? -39.89381 -5.18562  -55.16304 1.000 29.91628 ? 188 LEU   B CD1 1 
ATOM   3411 C  CD2 . LEU   B 1 188 ? -38.69144 -7.25742  -54.43097 1.000 33.74223 ? 188 LEU   B CD2 1 
ATOM   3412 N  N   . GLU   B 1 189 ? -37.11961 -7.39624  -58.83004 1.000 40.37634 ? 189 GLU   B N   1 
ATOM   3413 C  CA  . GLU   B 1 189 ? -35.67676 -7.37898  -59.06998 1.000 37.77447 ? 189 GLU   B CA  1 
ATOM   3414 C  C   . GLU   B 1 189 ? -35.33201 -6.71053  -60.39042 1.000 41.71255 ? 189 GLU   B C   1 
ATOM   3415 O  O   . GLU   B 1 189 ? -34.26479 -6.09621  -60.51188 1.000 40.03478 ? 189 GLU   B O   1 
ATOM   3416 C  CB  . GLU   B 1 189 ? -35.11278 -8.80016  -59.04645 1.000 29.03621 ? 189 GLU   B CB  1 
ATOM   3417 C  CG  . GLU   B 1 189 ? -35.17674 -9.48049  -57.69849 1.000 39.42109 ? 189 GLU   B CG  1 
ATOM   3418 C  CD  . GLU   B 1 189 ? -35.00101 -11.00132 -57.76984 1.000 51.34589 ? 189 GLU   B CD  1 
ATOM   3419 O  OE1 . GLU   B 1 189 ? -35.88643 -11.69582 -58.32484 1.000 47.76443 ? 189 GLU   B OE1 1 
ATOM   3420 O  OE2 . GLU   B 1 189 ? -34.00215 -11.50656 -57.22571 1.000 46.60320 ? 189 GLU   B OE2 1 
ATOM   3421 N  N   . ILE   B 1 190 ? -36.20145 -6.83441  -61.39305 1.000 39.34509 ? 190 ILE   B N   1 
ATOM   3422 C  CA  . ILE   B 1 190 ? -36.06728 -5.98203  -62.56458 1.000 38.81969 ? 190 ILE   B CA  1 
ATOM   3423 C  C   . ILE   B 1 190 ? -36.34628 -4.53845  -62.18619 1.000 43.47408 ? 190 ILE   B C   1 
ATOM   3424 O  O   . ILE   B 1 190 ? -35.62236 -3.61879  -62.59461 1.000 44.24228 ? 190 ILE   B O   1 
ATOM   3425 C  CB  . ILE   B 1 190 ? -36.99221 -6.45737  -63.70007 1.000 42.12043 ? 190 ILE   B CB  1 
ATOM   3426 C  CG1 . ILE   B 1 190 ? -36.39954 -7.66726  -64.40257 1.000 42.30548 ? 190 ILE   B CG1 1 
ATOM   3427 C  CG2 . ILE   B 1 190 ? -37.26215 -5.34619  -64.70391 1.000 43.57272 ? 190 ILE   B CG2 1 
ATOM   3428 C  CD1 . ILE   B 1 190 ? -36.73217 -8.91895  -63.75083 1.000 42.95340 ? 190 ILE   B CD1 1 
ATOM   3429 N  N   . LEU   B 1 191 ? -37.39674 -4.31439  -61.39520 1.000 36.74311 ? 191 LEU   B N   1 
ATOM   3430 C  CA  . LEU   B 1 191 ? -37.68516 -2.96487  -60.93324 1.000 37.81021 ? 191 LEU   B CA  1 
ATOM   3431 C  C   . LEU   B 1 191 ? -36.48341 -2.35005  -60.22734 1.000 39.84163 ? 191 LEU   B C   1 
ATOM   3432 O  O   . LEU   B 1 191 ? -36.27923 -1.13176  -60.29101 1.000 37.60424 ? 191 LEU   B O   1 
ATOM   3433 C  CB  . LEU   B 1 191 ? -38.88959 -2.98696  -60.00918 1.000 28.70383 ? 191 LEU   B CB  1 
ATOM   3434 C  CG  . LEU   B 1 191 ? -39.29523 -1.64371  -59.43224 1.000 30.50800 ? 191 LEU   B CG  1 
ATOM   3435 C  CD1 . LEU   B 1 191 ? -39.84318 -0.75805  -60.52377 1.000 33.02659 ? 191 LEU   B CD1 1 
ATOM   3436 C  CD2 . LEU   B 1 191 ? -40.33101 -1.83457  -58.35336 1.000 37.02833 ? 191 LEU   B CD2 1 
ATOM   3437 N  N   . ALA   B 1 192 ? -35.67386 -3.17814  -59.56191 1.000 38.49660 ? 192 ALA   B N   1 
ATOM   3438 C  CA  . ALA   B 1 192 ? -34.46974 -2.68252  -58.90388 1.000 39.82461 ? 192 ALA   B CA  1 
ATOM   3439 C  C   . ALA   B 1 192 ? -33.41530 -2.28664  -59.92144 1.000 29.41996 ? 192 ALA   B C   1 
ATOM   3440 O  O   . ALA   B 1 192 ? -32.92376 -1.15234  -59.91153 1.000 34.79537 ? 192 ALA   B O   1 
ATOM   3441 C  CB  . ALA   B 1 192 ? -33.90834 -3.73881  -57.95216 1.000 27.74929 ? 192 ALA   B CB  1 
ATOM   3442 N  N   . ALA   B 1 193 ? -33.06289 -3.21431  -60.81097 1.000 32.13112 ? 193 ALA   B N   1 
ATOM   3443 C  CA  . ALA   B 1 193 ? -31.97228 -2.98226  -61.75201 1.000 37.21673 ? 193 ALA   B CA  1 
ATOM   3444 C  C   . ALA   B 1 193 ? -32.19688 -1.73615  -62.60176 1.000 33.52910 ? 193 ALA   B C   1 
ATOM   3445 O  O   . ALA   B 1 193 ? -31.22688 -1.08845  -63.00369 1.000 36.30923 ? 193 ALA   B O   1 
ATOM   3446 C  CB  . ALA   B 1 193 ? -31.78468 -4.20556  -62.64493 1.000 34.80466 ? 193 ALA   B CB  1 
ATOM   3447 N  N   . ILE   B 1 194 ? -33.45277 -1.37112  -62.85596 1.000 26.41078 ? 194 ILE   B N   1 
ATOM   3448 C  CA  . ILE   B 1 194 ? -33.77616 -0.22768  -63.70778 1.000 32.03410 ? 194 ILE   B CA  1 
ATOM   3449 C  C   . ILE   B 1 194 ? -33.86477 1.06158   -62.90763 1.000 28.31640 ? 194 ILE   B C   1 
ATOM   3450 O  O   . ILE   B 1 194 ? -33.41933 2.11564   -63.36915 1.000 23.95497 ? 194 ILE   B O   1 
ATOM   3451 C  CB  . ILE   B 1 194 ? -35.09083 -0.50717  -64.46338 1.000 34.34321 ? 194 ILE   B CB  1 
ATOM   3452 C  CG1 . ILE   B 1 194 ? -34.86101 -1.54761  -65.55473 1.000 35.74765 ? 194 ILE   B CG1 1 
ATOM   3453 C  CG2 . ILE   B 1 194 ? -35.70358 0.77935   -65.02355 1.000 30.29836 ? 194 ILE   B CG2 1 
ATOM   3454 C  CD1 . ILE   B 1 194 ? -36.13154 -2.18733  -66.00811 1.000 43.81709 ? 194 ILE   B CD1 1 
ATOM   3455 N  N   . PHE   B 1 195 ? -34.48296 1.00902   -61.72650 1.000 26.53290 ? 195 PHE   B N   1 
ATOM   3456 C  CA  . PHE   B 1 195 ? -34.40702 2.14278   -60.81643 1.000 24.65737 ? 195 PHE   B CA  1 
ATOM   3457 C  C   . PHE   B 1 195 ? -32.95454 2.43697   -60.45869 1.000 24.16018 ? 195 PHE   B C   1 
ATOM   3458 O  O   . PHE   B 1 195 ? -32.51673 3.59460   -60.48185 1.000 23.31998 ? 195 PHE   B O   1 
ATOM   3459 C  CB  . PHE   B 1 195 ? -35.23232 1.86930   -59.55236 1.000 18.05557 ? 195 PHE   B CB  1 
ATOM   3460 C  CG  . PHE   B 1 195 ? -35.30906 3.03912   -58.62056 1.000 21.61292 ? 195 PHE   B CG  1 
ATOM   3461 C  CD1 . PHE   B 1 195 ? -36.18987 4.08070   -58.86938 1.000 16.72407 ? 195 PHE   B CD1 1 
ATOM   3462 C  CD2 . PHE   B 1 195 ? -34.48150 3.11179   -57.51192 1.000 18.73118 ? 195 PHE   B CD2 1 
ATOM   3463 C  CE1 . PHE   B 1 195 ? -36.24591 5.16868   -58.03943 1.000 20.74447 ? 195 PHE   B CE1 1 
ATOM   3464 C  CE2 . PHE   B 1 195 ? -34.53955 4.18609   -56.67050 1.000 16.93944 ? 195 PHE   B CE2 1 
ATOM   3465 C  CZ  . PHE   B 1 195 ? -35.41571 5.22527   -56.93153 1.000 22.64589 ? 195 PHE   B CZ  1 
ATOM   3466 N  N   . ALA   B 1 196 ? -32.19166 1.39203   -60.12562 1.000 21.54308 ? 196 ALA   B N   1 
ATOM   3467 C  CA  . ALA   B 1 196 ? -30.77052 1.57047   -59.85755 1.000 24.85449 ? 196 ALA   B CA  1 
ATOM   3468 C  C   . ALA   B 1 196 ? -30.10013 2.29778   -61.02033 1.000 26.00776 ? 196 ALA   B C   1 
ATOM   3469 O  O   . ALA   B 1 196 ? -29.54774 3.38815   -60.84580 1.000 17.94978 ? 196 ALA   B O   1 
ATOM   3470 C  CB  . ALA   B 1 196 ? -30.11394 0.21563   -59.59993 1.000 17.67625 ? 196 ALA   B CB  1 
ATOM   3471 N  N   . SER   B 1 197 ? -30.19378 1.71243   -62.22757 1.000 23.21169 ? 197 SER   B N   1 
ATOM   3472 C  CA  . SER   B 1 197 ? -29.66413 2.32707   -63.44628 1.000 23.26759 ? 197 SER   B CA  1 
ATOM   3473 C  C   . SER   B 1 197 ? -30.07775 3.79124   -63.60268 1.000 22.49466 ? 197 SER   B C   1 
ATOM   3474 O  O   . SER   B 1 197 ? -29.27381 4.62851   -64.01975 1.000 21.13069 ? 197 SER   B O   1 
ATOM   3475 C  CB  . SER   B 1 197 ? -30.12506 1.52311   -64.66401 1.000 20.83180 ? 197 SER   B CB  1 
ATOM   3476 O  OG  . SER   B 1 197 ? -29.51960 0.24229   -64.68332 1.000 17.80036 ? 197 SER   B OG  1 
ATOM   3477 N  N   . ALA   B 1 198 ? -31.32695 4.12152   -63.27722 1.000 23.60263 ? 198 ALA   B N   1 
ATOM   3478 C  CA  . ALA   B 1 198 ? -31.81684 5.46830   -63.54333 1.000 22.39543 ? 198 ALA   B CA  1 
ATOM   3479 C  C   . ALA   B 1 198 ? -31.24656 6.48340   -62.56800 1.000 24.16594 ? 198 ALA   B C   1 
ATOM   3480 O  O   . ALA   B 1 198 ? -30.99459 7.63374   -62.94011 1.000 22.75167 ? 198 ALA   B O   1 
ATOM   3481 C  CB  . ALA   B 1 198 ? -33.34316 5.48508   -63.49401 1.000 21.69897 ? 198 ALA   B CB  1 
ATOM   3482 N  N   . ILE   B 1 199 ? -31.05744 6.08622   -61.30651 1.000 22.47904 ? 199 ILE   B N   1 
ATOM   3483 C  CA  . ILE   B 1 199 ? -30.52588 6.99936   -60.30330 1.000 19.73827 ? 199 ILE   B CA  1 
ATOM   3484 C  C   . ILE   B 1 199 ? -29.01118 6.91492   -60.17755 1.000 14.07410 ? 199 ILE   B C   1 
ATOM   3485 O  O   . ILE   B 1 199 ? -28.43329 7.67364   -59.39339 1.000 15.91462 ? 199 ILE   B O   1 
ATOM   3486 C  CB  . ILE   B 1 199 ? -31.15988 6.71628   -58.92776 1.000 22.81407 ? 199 ILE   B CB  1 
ATOM   3487 C  CG1 . ILE   B 1 199 ? -30.76716 5.30527   -58.45746 1.000 18.81987 ? 199 ILE   B CG1 1 
ATOM   3488 C  CG2 . ILE   B 1 199 ? -32.70608 6.90013   -58.98471 1.000 21.68059 ? 199 ILE   B CG2 1 
ATOM   3489 C  CD1 . ILE   B 1 199 ? -30.91575 5.09902   -56.96440 1.000 16.28843 ? 199 ILE   B CD1 1 
ATOM   3490 N  N   . HIS   B 1 200 ? -28.35110 6.03665   -60.94578 1.000 14.09727 ? 200 HIS   B N   1 
ATOM   3491 C  CA  . HIS   B 1 200 ? -26.98729 5.59263   -60.64437 1.000 13.99728 ? 200 HIS   B CA  1 
ATOM   3492 C  C   . HIS   B 1 200 ? -25.91771 6.67826   -60.80999 1.000 14.12705 ? 200 HIS   B C   1 
ATOM   3493 O  O   . HIS   B 1 200 ? -24.76607 6.44546   -60.42025 1.000 12.32952 ? 200 HIS   B O   1 
ATOM   3494 C  CB  . HIS   B 1 200 ? -26.61887 4.39485   -61.51530 1.000 14.64739 ? 200 HIS   B CB  1 
ATOM   3495 C  CG  . HIS   B 1 200 ? -25.88580 4.76085   -62.77572 1.000 15.70407 ? 200 HIS   B CG  1 
ATOM   3496 N  ND1 . HIS   B 1 200 ? -26.51215 5.32554   -63.86404 1.000 15.10558 ? 200 HIS   B ND1 1 
ATOM   3497 C  CD2 . HIS   B 1 200 ? -24.57730 4.64593   -63.11425 1.000 12.34358 ? 200 HIS   B CD2 1 
ATOM   3498 C  CE1 . HIS   B 1 200 ? -25.62448 5.53432   -64.82035 1.000 19.37444 ? 200 HIS   B CE1 1 
ATOM   3499 N  NE2 . HIS   B 1 200 ? -24.44421 5.12905   -64.39132 1.000 14.27302 ? 200 HIS   B NE2 1 
ATOM   3500 N  N   . ASP   B 1 201 ? -26.25037 7.85254   -61.35687 1.000 12.90623 ? 201 ASP   B N   1 
ATOM   3501 C  CA  . ASP   B 1 201 ? -25.26230 8.92996   -61.42195 1.000 10.15231 ? 201 ASP   B CA  1 
ATOM   3502 C  C   . ASP   B 1 201 ? -25.88642 10.28439  -61.12181 1.000 13.62171 ? 201 ASP   B C   1 
ATOM   3503 O  O   . ASP   B 1 201 ? -25.34608 11.31896  -61.52551 1.000 16.82975 ? 201 ASP   B O   1 
ATOM   3504 C  CB  . ASP   B 1 201 ? -24.57240 8.98489   -62.78981 1.000 14.59351 ? 201 ASP   B CB  1 
ATOM   3505 C  CG  . ASP   B 1 201 ? -23.37841 8.07468   -62.87702 1.000 11.98780 ? 201 ASP   B CG  1 
ATOM   3506 O  OD1 . ASP   B 1 201 ? -22.74578 7.86312   -61.82547 1.000 13.99714 ? 201 ASP   B OD1 1 
ATOM   3507 O  OD2 . ASP   B 1 201 ? -23.07824 7.56683   -63.98321 1.000 11.29840 ? 201 ASP   B OD2 1 
ATOM   3508 N  N   . VAL   B 1 202 ? -27.00398 10.30896  -60.39295 1.000 15.10837 ? 202 VAL   B N   1 
ATOM   3509 C  CA  . VAL   B 1 202 ? -27.75730 11.54433  -60.24513 1.000 13.99206 ? 202 VAL   B CA  1 
ATOM   3510 C  C   . VAL   B 1 202 ? -26.95395 12.55625  -59.43758 1.000 14.89498 ? 202 VAL   B C   1 
ATOM   3511 O  O   . VAL   B 1 202 ? -26.29535 12.21155  -58.44916 1.000 11.90894 ? 202 VAL   B O   1 
ATOM   3512 C  CB  . VAL   B 1 202 ? -29.13805 11.26519  -59.61857 1.000 16.15058 ? 202 VAL   B CB  1 
ATOM   3513 C  CG1 . VAL   B 1 202 ? -29.03752 10.91757  -58.10412 1.000 13.75314 ? 202 VAL   B CG1 1 
ATOM   3514 C  CG2 . VAL   B 1 202 ? -30.04951 12.45394  -59.82681 1.000 16.92454 ? 202 VAL   B CG2 1 
ATOM   3515 N  N   . ASP   B 1 203 ? -26.99692 13.82139  -59.86574 1.000 15.39471 ? 203 ASP   B N   1 
ATOM   3516 C  CA  . ASP   B 1 203 ? -26.28268 14.90757  -59.18791 1.000 12.09127 ? 203 ASP   B CA  1 
ATOM   3517 C  C   . ASP   B 1 203 ? -24.76571 14.71914  -59.24308 1.000 12.40074 ? 203 ASP   B C   1 
ATOM   3518 O  O   . ASP   B 1 203 ? -24.03015 15.17551  -58.35913 1.000 15.67726 ? 203 ASP   B O   1 
ATOM   3519 C  CB  . ASP   B 1 203 ? -26.76619 15.06587  -57.73899 1.000 13.12100 ? 203 ASP   B CB  1 
ATOM   3520 C  CG  . ASP   B 1 203 ? -26.40076 16.41123  -57.14765 1.000 16.88352 ? 203 ASP   B CG  1 
ATOM   3521 O  OD1 . ASP   B 1 203 ? -26.46131 17.42703  -57.87314 1.000 28.16678 ? 203 ASP   B OD1 1 
ATOM   3522 O  OD2 . ASP   B 1 203 ? -26.02864 16.46411  -55.96494 1.000 17.59973 ? 203 ASP   B OD2 1 
ATOM   3523 N  N   . HIS   B 1 204 ? -24.29249 14.07971  -60.28963 1.000 11.47332 ? 204 HIS   B N   1 
ATOM   3524 C  CA  . HIS   B 1 204 ? -22.85732 13.94391  -60.51762 1.000 14.61937 ? 204 HIS   B CA  1 
ATOM   3525 C  C   . HIS   B 1 204 ? -22.25322 15.30423  -60.86514 1.000 14.09129 ? 204 HIS   B C   1 
ATOM   3526 O  O   . HIS   B 1 204 ? -22.76619 15.99478  -61.75534 1.000 15.31048 ? 204 HIS   B O   1 
ATOM   3527 C  CB  . HIS   B 1 204 ? -22.64141 12.95149  -61.65241 1.000 9.68659  ? 204 HIS   B CB  1 
ATOM   3528 C  CG  . HIS   B 1 204 ? -21.26959 12.37828  -61.72108 1.000 10.16307 ? 204 HIS   B CG  1 
ATOM   3529 N  ND1 . HIS   B 1 204 ? -20.14066 13.15589  -61.83947 1.000 12.22575 ? 204 HIS   B ND1 1 
ATOM   3530 C  CD2 . HIS   B 1 204 ? -20.84633 11.08990  -61.75788 1.000 11.48162 ? 204 HIS   B CD2 1 
ATOM   3531 C  CE1 . HIS   B 1 204 ? -19.07804 12.37194  -61.91994 1.000 11.80077 ? 204 HIS   B CE1 1 
ATOM   3532 N  NE2 . HIS   B 1 204 ? -19.48235 11.11421  -61.87960 1.000 8.05363  ? 204 HIS   B NE2 1 
ATOM   3533 N  N   . PRO   B 1 205 ? -21.18119 15.73185  -60.19218 1.000 15.41454 ? 205 PRO   B N   1 
ATOM   3534 C  CA  . PRO   B 1 205 ? -20.59879 17.04539  -60.48341 1.000 16.10233 ? 205 PRO   B CA  1 
ATOM   3535 C  C   . PRO   B 1 205 ? -19.59672 17.03794  -61.61706 1.000 16.54758 ? 205 PRO   B C   1 
ATOM   3536 O  O   . PRO   B 1 205 ? -18.99228 18.07959  -61.88428 1.000 23.50929 ? 205 PRO   B O   1 
ATOM   3537 C  CB  . PRO   B 1 205 ? -19.91671 17.40241  -59.16604 1.000 13.79015 ? 205 PRO   B CB  1 
ATOM   3538 C  CG  . PRO   B 1 205 ? -19.40415 16.06259  -58.69804 1.000 15.93587 ? 205 PRO   B CG  1 
ATOM   3539 C  CD  . PRO   B 1 205 ? -20.51417 15.09521  -59.04466 1.000 17.72694 ? 205 PRO   B CD  1 
ATOM   3540 N  N   . GLY   B 1 206 ? -19.39001 15.90613  -62.27710 1.000 15.70493 ? 206 GLY   B N   1 
ATOM   3541 C  CA  . GLY   B 1 206 ? -18.44368 15.85482  -63.36921 1.000 17.47556 ? 206 GLY   B CA  1 
ATOM   3542 C  C   . GLY   B 1 206 ? -17.00668 15.63564  -62.96391 1.000 17.28278 ? 206 GLY   B C   1 
ATOM   3543 O  O   . GLY   B 1 206 ? -16.10108 15.85462  -63.77428 1.000 22.85521 ? 206 GLY   B O   1 
ATOM   3544 N  N   . VAL   B 1 207 ? -16.76015 15.21338  -61.73011 1.000 17.07044 ? 207 VAL   B N   1 
ATOM   3545 C  CA  . VAL   B 1 207 ? -15.41297 14.90939  -61.27324 1.000 18.91629 ? 207 VAL   B CA  1 
ATOM   3546 C  C   . VAL   B 1 207 ? -15.41341 13.52783  -60.63577 1.000 18.00691 ? 207 VAL   B C   1 
ATOM   3547 O  O   . VAL   B 1 207 ? -16.45763 12.98901  -60.26487 1.000 20.38021 ? 207 VAL   B O   1 
ATOM   3548 C  CB  . VAL   B 1 207 ? -14.88780 15.96389  -60.28116 1.000 23.58345 ? 207 VAL   B CB  1 
ATOM   3549 C  CG1 . VAL   B 1 207 ? -14.79184 17.29943  -60.96344 1.000 20.39430 ? 207 VAL   B CG1 1 
ATOM   3550 C  CG2 . VAL   B 1 207 ? -15.79658 16.05849  -59.07789 1.000 19.56001 ? 207 VAL   B CG2 1 
ATOM   3551 N  N   . SER   B 1 208 ? -14.22249 12.95408  -60.51500 1.000 17.62015 ? 208 SER   B N   1 
ATOM   3552 C  CA  . SER   B 1 208 ? -14.11202 11.61795  -59.96538 1.000 15.91564 ? 208 SER   B CA  1 
ATOM   3553 C  C   . SER   B 1 208 ? -14.16656 11.65241  -58.43792 1.000 15.37235 ? 208 SER   B C   1 
ATOM   3554 O  O   . SER   B 1 208 ? -14.00337 12.69805  -57.79741 1.000 16.45978 ? 208 SER   B O   1 
ATOM   3555 C  CB  . SER   B 1 208 ? -12.80902 10.97534  -60.41366 1.000 17.82408 ? 208 SER   B CB  1 
ATOM   3556 O  OG  . SER   B 1 208 ? -11.71818 11.80127  -60.03085 1.000 20.50865 ? 208 SER   B OG  1 
ATOM   3557 N  N   . ASN   B 1 209 ? -14.37656 10.47593  -57.85581 1.000 18.89639 ? 209 ASN   B N   1 
ATOM   3558 C  CA  . ASN   B 1 209 ? -14.19298 10.31965  -56.41775 1.000 17.12050 ? 209 ASN   B CA  1 
ATOM   3559 C  C   . ASN   B 1 209 ? -12.82613 10.82970  -55.97624 1.000 16.13716 ? 209 ASN   B C   1 
ATOM   3560 O  O   . ASN   B 1 209 ? -12.71385 11.59404  -55.00905 1.000 20.30951 ? 209 ASN   B O   1 
ATOM   3561 C  CB  . ASN   B 1 209 ? -14.36738 8.85105   -56.03507 1.000 10.36676 ? 209 ASN   B CB  1 
ATOM   3562 C  CG  . ASN   B 1 209 ? -15.83843 8.43895   -55.96151 1.000 16.02049 ? 209 ASN   B CG  1 
ATOM   3563 O  OD1 . ASN   B 1 209 ? -16.71809 9.27927   -55.71999 1.000 14.37489 ? 209 ASN   B OD1 1 
ATOM   3564 N  ND2 . ASN   B 1 209 ? -16.10800 7.14504   -56.14284 1.000 7.72216  ? 209 ASN   B ND2 1 
ATOM   3565 N  N   . GLN   B 1 210 ? -11.76833 10.40364  -56.66426 1.000 14.74101 ? 210 GLN   B N   1 
ATOM   3566 C  CA  . GLN   B 1 210 ? -10.42552 10.78972  -56.24014 1.000 18.40538 ? 210 GLN   B CA  1 
ATOM   3567 C  C   . GLN   B 1 210 ? -10.25813 12.30793  -56.25570 1.000 20.67080 ? 210 GLN   B C   1 
ATOM   3568 O  O   . GLN   B 1 210 ? -9.66452  12.89076  -55.33664 1.000 22.70632 ? 210 GLN   B O   1 
ATOM   3569 C  CB  . GLN   B 1 210 ? -9.38376  10.10753  -57.12706 1.000 24.87723 ? 210 GLN   B CB  1 
ATOM   3570 C  CG  . GLN   B 1 210 ? -7.96851  10.11402  -56.54399 1.000 24.51449 ? 210 GLN   B CG  1 
ATOM   3571 C  CD  . GLN   B 1 210 ? -7.87884  9.32277   -55.25141 1.000 30.64840 ? 210 GLN   B CD  1 
ATOM   3572 O  OE1 . GLN   B 1 210 ? -7.90432  8.09093   -55.26312 1.000 27.78567 ? 210 GLN   B OE1 1 
ATOM   3573 N  NE2 . GLN   B 1 210 ? -7.78311  10.03090  -54.12503 1.000 25.33039 ? 210 GLN   B NE2 1 
ATOM   3574 N  N   . PHE   B 1 211 ? -10.81951 12.97430  -57.26161 1.000 17.78004 ? 211 PHE   B N   1 
ATOM   3575 C  CA  . PHE   B 1 211 ? -10.83283 14.43236  -57.24169 1.000 16.49182 ? 211 PHE   B CA  1 
ATOM   3576 C  C   . PHE   B 1 211 ? -11.53696 14.95390  -56.00177 1.000 20.05271 ? 211 PHE   B C   1 
ATOM   3577 O  O   . PHE   B 1 211 ? -10.99587 15.78849  -55.27021 1.000 22.70282 ? 211 PHE   B O   1 
ATOM   3578 C  CB  . PHE   B 1 211 ? -11.50301 14.97424  -58.50474 1.000 18.32564 ? 211 PHE   B CB  1 
ATOM   3579 C  CG  . PHE   B 1 211 ? -11.55037 16.47767  -58.57026 1.000 20.38184 ? 211 PHE   B CG  1 
ATOM   3580 C  CD1 . PHE   B 1 211 ? -10.47393 17.19700  -59.05538 1.000 19.56702 ? 211 PHE   B CD1 1 
ATOM   3581 C  CD2 . PHE   B 1 211 ? -12.65827 17.16489  -58.13767 1.000 20.04372 ? 211 PHE   B CD2 1 
ATOM   3582 C  CE1 . PHE   B 1 211 ? -10.51830 18.57350  -59.12252 1.000 29.24213 ? 211 PHE   B CE1 1 
ATOM   3583 C  CE2 . PHE   B 1 211 ? -12.71335 18.53914  -58.21181 1.000 27.91204 ? 211 PHE   B CE2 1 
ATOM   3584 C  CZ  . PHE   B 1 211 ? -11.63608 19.24684  -58.69985 1.000 27.06248 ? 211 PHE   B CZ  1 
ATOM   3585 N  N   . LEU   B 1 212 ? -12.76410 14.48496  -55.76259 1.000 20.04026 ? 212 LEU   B N   1 
ATOM   3586 C  CA  . LEU   B 1 212 ? -13.52972 14.94611  -54.61023 1.000 18.61629 ? 212 LEU   B CA  1 
ATOM   3587 C  C   . LEU   B 1 212 ? -12.77181 14.70646  -53.31218 1.000 17.55443 ? 212 LEU   B C   1 
ATOM   3588 O  O   . LEU   B 1 212 ? -12.80186 15.54622  -52.40072 1.000 19.23798 ? 212 LEU   B O   1 
ATOM   3589 C  CB  . LEU   B 1 212 ? -14.89353 14.25117  -54.58061 1.000 18.86243 ? 212 LEU   B CB  1 
ATOM   3590 C  CG  . LEU   B 1 212 ? -15.87086 14.82595  -55.60186 1.000 13.63203 ? 212 LEU   B CG  1 
ATOM   3591 C  CD1 . LEU   B 1 212 ? -16.95344 13.83930  -55.92709 1.000 13.39560 ? 212 LEU   B CD1 1 
ATOM   3592 C  CD2 . LEU   B 1 212 ? -16.46270 16.11240  -55.05677 1.000 20.26034 ? 212 LEU   B CD2 1 
ATOM   3593 N  N   . ILE   B 1 213 ? -12.08498 13.56997  -53.21977 1.000 17.07728 ? 213 ILE   B N   1 
ATOM   3594 C  CA  . ILE   B 1 213 ? -11.26513 13.25686  -52.05239 1.000 19.88580 ? 213 ILE   B CA  1 
ATOM   3595 C  C   . ILE   B 1 213 ? -10.09784 14.23967  -51.92834 1.000 24.81706 ? 213 ILE   B C   1 
ATOM   3596 O  O   . ILE   B 1 213 ? -9.95017  14.93388  -50.91540 1.000 24.94718 ? 213 ILE   B O   1 
ATOM   3597 C  CB  . ILE   B 1 213 ? -10.76815 11.80331  -52.13633 1.000 17.56484 ? 213 ILE   B CB  1 
ATOM   3598 C  CG1 . ILE   B 1 213 ? -11.96310 10.84558  -52.00896 1.000 12.90780 ? 213 ILE   B CG1 1 
ATOM   3599 C  CG2 . ILE   B 1 213 ? -9.70485  11.56375  -51.07283 1.000 17.07007 ? 213 ILE   B CG2 1 
ATOM   3600 C  CD1 . ILE   B 1 213 ? -11.64750 9.36106   -52.25627 1.000 12.19224 ? 213 ILE   B CD1 1 
ATOM   3601 N  N   . ASN   B 1 214 ? -9.27071  14.32750  -52.97582 1.000 25.66326 ? 214 ASN   B N   1 
ATOM   3602 C  CA  . ASN   B 1 214 ? -8.07411  15.16962  -52.94443 1.000 26.19250 ? 214 ASN   B CA  1 
ATOM   3603 C  C   . ASN   B 1 214 ? -8.37976  16.62283  -52.63599 1.000 27.37898 ? 214 ASN   B C   1 
ATOM   3604 O  O   . ASN   B 1 214 ? -7.50565  17.34490  -52.14312 1.000 28.12582 ? 214 ASN   B O   1 
ATOM   3605 C  CB  . ASN   B 1 214 ? -7.34781  15.10672  -54.28017 1.000 18.18457 ? 214 ASN   B CB  1 
ATOM   3606 C  CG  . ASN   B 1 214 ? -6.79583  13.73911  -54.56460 1.000 23.55048 ? 214 ASN   B CG  1 
ATOM   3607 O  OD1 . ASN   B 1 214 ? -6.61151  12.92555  -53.64950 1.000 21.15568 ? 214 ASN   B OD1 1 
ATOM   3608 N  ND2 . ASN   B 1 214 ? -6.53366  13.46535  -55.84381 1.000 26.90828 ? 214 ASN   B ND2 1 
ATOM   3609 N  N   . THR   B 1 215 ? -9.58398  17.08712  -52.94119 1.000 23.48650 ? 215 THR   B N   1 
ATOM   3610 C  CA  . THR   B 1 215 ? -9.90379  18.48551  -52.72572 1.000 23.41405 ? 215 THR   B CA  1 
ATOM   3611 C  C   . THR   B 1 215 ? -10.61051 18.72852  -51.40412 1.000 23.88203 ? 215 THR   B C   1 
ATOM   3612 O  O   . THR   B 1 215 ? -11.08804 19.84358  -51.17187 1.000 26.61611 ? 215 THR   B O   1 
ATOM   3613 C  CB  . THR   B 1 215 ? -10.75335 19.01624  -53.88364 1.000 28.22128 ? 215 THR   B CB  1 
ATOM   3614 O  OG1 . THR   B 1 215 ? -11.99222 18.29274  -53.95022 1.000 23.09480 ? 215 THR   B OG1 1 
ATOM   3615 C  CG2 . THR   B 1 215 ? -9.99305  18.85532  -55.18605 1.000 23.10183 ? 215 THR   B CG2 1 
ATOM   3616 N  N   . ASN   B 1 216 ? -10.71339 17.70953  -50.54353 1.000 26.78043 ? 216 ASN   B N   1 
ATOM   3617 C  CA  . ASN   B 1 216 ? -11.37600 17.85887  -49.24575 1.000 22.37619 ? 216 ASN   B CA  1 
ATOM   3618 C  C   . ASN   B 1 216 ? -12.80703 18.36521  -49.41516 1.000 21.97009 ? 216 ASN   B C   1 
ATOM   3619 O  O   . ASN   B 1 216 ? -13.27616 19.23963  -48.67949 1.000 23.09857 ? 216 ASN   B O   1 
ATOM   3620 C  CB  . ASN   B 1 216 ? -10.56850 18.78747  -48.33374 1.000 20.80254 ? 216 ASN   B CB  1 
ATOM   3621 C  CG  . ASN   B 1 216 ? -9.08646  18.48586  -48.37665 1.000 25.35306 ? 216 ASN   B CG  1 
ATOM   3622 O  OD1 . ASN   B 1 216 ? -8.62933  17.50639  -47.78969 1.000 29.17090 ? 216 ASN   B OD1 1 
ATOM   3623 N  ND2 . ASN   B 1 216 ? -8.32340  19.32146  -49.08684 1.000 25.09672 ? 216 ASN   B ND2 1 
ATOM   3624 N  N   . SER   B 1 217 ? -13.50163 17.83059  -50.41226 1.000 26.45775 ? 217 SER   B N   1 
ATOM   3625 C  CA  . SER   B 1 217 ? -14.85546 18.27497  -50.68740 1.000 17.78715 ? 217 SER   B CA  1 
ATOM   3626 C  C   . SER   B 1 217 ? -15.80467 17.83060  -49.58045 1.000 18.00251 ? 217 SER   B C   1 
ATOM   3627 O  O   . SER   B 1 217 ? -15.53937 16.88719  -48.82320 1.000 18.21261 ? 217 SER   B O   1 
ATOM   3628 C  CB  . SER   B 1 217 ? -15.34350 17.74151  -52.03797 1.000 20.97130 ? 217 SER   B CB  1 
ATOM   3629 O  OG  . SER   B 1 217 ? -15.70142 16.36761  -51.97088 1.000 20.38535 ? 217 SER   B OG  1 
ATOM   3630 N  N   . GLU   B 1 218 ? -16.93524 18.53114  -49.51246 1.000 15.08811 ? 218 GLU   B N   1 
ATOM   3631 C  CA  . GLU   B 1 218 ? -17.98792 18.19209  -48.56398 1.000 21.73385 ? 218 GLU   B CA  1 
ATOM   3632 C  C   . GLU   B 1 218 ? -18.50604 16.77857  -48.79458 1.000 16.62370 ? 218 GLU   B C   1 
ATOM   3633 O  O   . GLU   B 1 218 ? -18.78713 16.04159  -47.83635 1.000 15.14278 ? 218 GLU   B O   1 
ATOM   3634 C  CB  . GLU   B 1 218 ? -19.12738 19.21267  -48.68115 1.000 24.80932 ? 218 GLU   B CB  1 
ATOM   3635 C  CG  . GLU   B 1 218 ? -19.03557 20.37862  -47.73943 1.000 29.48534 ? 218 GLU   B CG  1 
ATOM   3636 C  CD  . GLU   B 1 218 ? -19.36615 19.96539  -46.31279 1.000 39.49224 ? 218 GLU   B CD  1 
ATOM   3637 O  OE1 . GLU   B 1 218 ? -18.82306 20.58028  -45.36791 1.000 40.55457 ? 218 GLU   B OE1 1 
ATOM   3638 O  OE2 . GLU   B 1 218 ? -20.16731 19.01124  -46.14419 1.000 45.53891 ? 218 GLU   B OE2 1 
ATOM   3639 N  N   . LEU   B 1 219 ? -18.64913 16.38556  -50.05917 1.000 16.90961 ? 219 LEU   B N   1 
ATOM   3640 C  CA  . LEU   B 1 219 ? -19.05171 15.01567  -50.36210 1.000 16.12008 ? 219 LEU   B CA  1 
ATOM   3641 C  C   . LEU   B 1 219 ? -18.09125 14.00838  -49.73074 1.000 14.03998 ? 219 LEU   B C   1 
ATOM   3642 O  O   . LEU   B 1 219 ? -18.51383 13.07597  -49.03545 1.000 12.45626 ? 219 LEU   B O   1 
ATOM   3643 C  CB  . LEU   B 1 219 ? -19.13967 14.81803  -51.87491 1.000 13.04457 ? 219 LEU   B CB  1 
ATOM   3644 C  CG  . LEU   B 1 219 ? -20.44698 15.30401  -52.52492 1.000 21.15743 ? 219 LEU   B CG  1 
ATOM   3645 C  CD1 . LEU   B 1 219 ? -20.48621 14.97907  -54.00105 1.000 16.04684 ? 219 LEU   B CD1 1 
ATOM   3646 C  CD2 . LEU   B 1 219 ? -21.66052 14.71610  -51.84924 1.000 15.02229 ? 219 LEU   B CD2 1 
ATOM   3647 N  N   . ALA   B 1 220 ? -16.78971 14.20707  -49.92610 1.000 12.03871 ? 220 ALA   B N   1 
ATOM   3648 C  CA  . ALA   B 1 220 ? -15.82654 13.23454  -49.42856 1.000 11.98787 ? 220 ALA   B CA  1 
ATOM   3649 C  C   . ALA   B 1 220 ? -15.74701 13.25927  -47.90222 1.000 12.84753 ? 220 ALA   B C   1 
ATOM   3650 O  O   . ALA   B 1 220 ? -15.51475 12.21674  -47.27329 1.000 14.35546 ? 220 ALA   B O   1 
ATOM   3651 C  CB  . ALA   B 1 220 ? -14.46739 13.47914  -50.08290 1.000 11.08102 ? 220 ALA   B CB  1 
ATOM   3652 N  N   . LEU   B 1 221 ? -15.98732 14.41868  -47.28423 1.000 16.66756 ? 221 LEU   B N   1 
ATOM   3653 C  CA  . LEU   B 1 221 ? -16.06447 14.46477  -45.82663 1.000 14.56653 ? 221 LEU   B CA  1 
ATOM   3654 C  C   . LEU   B 1 221 ? -17.28803 13.70729  -45.33357 1.000 14.76907 ? 221 LEU   B C   1 
ATOM   3655 O  O   . LEU   B 1 221 ? -17.20508 12.90893  -44.38895 1.000 14.19943 ? 221 LEU   B O   1 
ATOM   3656 C  CB  . LEU   B 1 221 ? -16.11147 15.91205  -45.35322 1.000 13.86042 ? 221 LEU   B CB  1 
ATOM   3657 C  CG  . LEU   B 1 221 ? -15.59156 16.26012  -43.96313 1.000 20.72300 ? 221 LEU   B CG  1 
ATOM   3658 C  CD1 . LEU   B 1 221 ? -14.08617 16.12178  -43.95167 1.000 26.35357 ? 221 LEU   B CD1 1 
ATOM   3659 C  CD2 . LEU   B 1 221 ? -15.99158 17.69143  -43.66302 1.000 26.69001 ? 221 LEU   B CD2 1 
ATOM   3660 N  N   . MET   B 1 222 ? -18.43654 13.96201  -45.96867 1.000 14.32394 ? 222 MET   B N   1 
ATOM   3661 C  CA  . MET   B 1 222 ? -19.67966 13.27019  -45.64112 1.000 14.25350 ? 222 MET   B CA  1 
ATOM   3662 C  C   . MET   B 1 222 ? -19.52343 11.75100  -45.74178 1.000 13.95394 ? 222 MET   B C   1 
ATOM   3663 O  O   . MET   B 1 222 ? -19.96076 11.00570  -44.86254 1.000 13.95823 ? 222 MET   B O   1 
ATOM   3664 C  CB  . MET   B 1 222 ? -20.77739 13.76852  -46.58948 1.000 15.47923 ? 222 MET   B CB  1 
ATOM   3665 C  CG  . MET   B 1 222 ? -22.15030 13.15810  -46.37378 1.000 20.25426 ? 222 MET   B CG  1 
ATOM   3666 S  SD  . MET   B 1 222 ? -22.90908 13.85960  -44.90039 1.000 28.34428 ? 222 MET   B SD  1 
ATOM   3667 C  CE  . MET   B 1 222 ? -23.26293 15.53978  -45.47440 1.000 30.13078 ? 222 MET   B CE  1 
ATOM   3668 N  N   . TYR   B 1 223 ? -18.90127 11.26433  -46.81231 1.000 14.05318 ? 223 TYR   B N   1 
ATOM   3669 C  CA  . TYR   B 1 223 ? -18.90871 9.83811   -47.07570 1.000 10.05155 ? 223 TYR   B CA  1 
ATOM   3670 C  C   . TYR   B 1 223 ? -17.58703 9.16391   -46.76823 1.000 11.99018 ? 223 TYR   B C   1 
ATOM   3671 O  O   . TYR   B 1 223 ? -17.38704 8.02268   -47.17932 1.000 7.36364  ? 223 TYR   B O   1 
ATOM   3672 C  CB  . TYR   B 1 223 ? -19.34121 9.58788   -48.51051 1.000 10.26134 ? 223 TYR   B CB  1 
ATOM   3673 C  CG  . TYR   B 1 223 ? -20.82963 9.85365   -48.66013 1.000 10.18668 ? 223 TYR   B CG  1 
ATOM   3674 C  CD1 . TYR   B 1 223 ? -21.75317 9.05153   -48.00207 1.000 9.59543  ? 223 TYR   B CD1 1 
ATOM   3675 C  CD2 . TYR   B 1 223 ? -21.31000 10.89420  -49.45024 1.000 9.87577  ? 223 TYR   B CD2 1 
ATOM   3676 C  CE1 . TYR   B 1 223 ? -23.10716 9.26695   -48.12167 1.000 11.62578 ? 223 TYR   B CE1 1 
ATOM   3677 C  CE2 . TYR   B 1 223 ? -22.69392 11.11823  -49.58640 1.000 7.11296  ? 223 TYR   B CE2 1 
ATOM   3678 C  CZ  . TYR   B 1 223 ? -23.57541 10.30579  -48.91077 1.000 10.57575 ? 223 TYR   B CZ  1 
ATOM   3679 O  OH  . TYR   B 1 223 ? -24.93465 10.50265  -49.00898 1.000 10.36144 ? 223 TYR   B OH  1 
ATOM   3680 N  N   . ASN   B 1 224 ? -16.68953 9.83482   -46.03751 1.000 11.27506 ? 224 ASN   B N   1 
ATOM   3681 C  CA  . ASN   B 1 224 ? -15.44098 9.21501   -45.56792 1.000 10.46251 ? 224 ASN   B CA  1 
ATOM   3682 C  C   . ASN   B 1 224 ? -14.67169 8.54472   -46.69744 1.000 10.99234 ? 224 ASN   B C   1 
ATOM   3683 O  O   . ASN   B 1 224 ? -14.21047 7.40646   -46.57187 1.000 13.11956 ? 224 ASN   B O   1 
ATOM   3684 C  CB  . ASN   B 1 224 ? -15.72969 8.22650   -44.45037 1.000 9.77752  ? 224 ASN   B CB  1 
ATOM   3685 C  CG  . ASN   B 1 224 ? -16.43448 8.88484   -43.32739 1.000 14.99159 ? 224 ASN   B CG  1 
ATOM   3686 O  OD1 . ASN   B 1 224 ? -15.83671 9.72022   -42.64962 1.000 13.91178 ? 224 ASN   B OD1 1 
ATOM   3687 N  ND2 . ASN   B 1 224 ? -17.73856 8.59871   -43.16279 1.000 8.65573  ? 224 ASN   B ND2 1 
ATOM   3688 N  N   . ASP   B 1 225 ? -14.56166 9.24879   -47.82269 1.000 9.34718  ? 225 ASP   B N   1 
ATOM   3689 C  CA  . ASP   B 1 225 ? -13.74000 8.84665   -48.96528 1.000 10.78699 ? 225 ASP   B CA  1 
ATOM   3690 C  C   . ASP   B 1 225 ? -14.15229 7.50877   -49.60222 1.000 12.01032 ? 225 ASP   B C   1 
ATOM   3691 O  O   . ASP   B 1 225 ? -13.46686 7.03276   -50.50036 1.000 10.18886 ? 225 ASP   B O   1 
ATOM   3692 C  CB  . ASP   B 1 225 ? -12.24906 8.81143   -48.56827 1.000 9.94681  ? 225 ASP   B CB  1 
ATOM   3693 C  CG  . ASP   B 1 225 ? -11.74615 10.17962  -48.08737 1.000 10.56405 ? 225 ASP   B CG  1 
ATOM   3694 O  OD1 . ASP   B 1 225 ? -12.48030 11.18438  -48.24592 1.000 12.99668 ? 225 ASP   B OD1 1 
ATOM   3695 O  OD2 . ASP   B 1 225 ? -10.62795 10.25726  -47.55223 1.000 14.17939 ? 225 ASP   B OD2 1 
ATOM   3696 N  N   . SER   B 1 226 ? -15.24870 6.87508   -49.18475 1.000 11.79340 ? 226 SER   B N   1 
ATOM   3697 C  CA  . SER   B 1 226 ? -15.59065 5.55632   -49.70826 1.000 13.30229 ? 226 SER   B CA  1 
ATOM   3698 C  C   . SER   B 1 226 ? -16.80105 5.67554   -50.61523 1.000 13.78091 ? 226 SER   B C   1 
ATOM   3699 O  O   . SER   B 1 226 ? -17.88149 6.05753   -50.15301 1.000 11.77505 ? 226 SER   B O   1 
ATOM   3700 C  CB  . SER   B 1 226 ? -15.87063 4.55560   -48.58886 1.000 15.00661 ? 226 SER   B CB  1 
ATOM   3701 O  OG  . SER   B 1 226 ? -14.88728 4.64083   -47.56425 1.000 19.87922 ? 226 SER   B OG  1 
ATOM   3702 N  N   . SER   B 1 227 ? -16.61488 5.34200   -51.89716 1.000 12.60881 ? 227 SER   B N   1 
ATOM   3703 C  CA  . SER   B 1 227 ? -17.68021 5.38629   -52.89810 1.000 12.83327 ? 227 SER   B CA  1 
ATOM   3704 C  C   . SER   B 1 227 ? -18.47636 6.68481   -52.76846 1.000 11.97789 ? 227 SER   B C   1 
ATOM   3705 O  O   . SER   B 1 227 ? -19.70688 6.70105   -52.77776 1.000 13.17101 ? 227 SER   B O   1 
ATOM   3706 C  CB  . SER   B 1 227 ? -18.57819 4.15588   -52.78689 1.000 14.00036 ? 227 SER   B CB  1 
ATOM   3707 O  OG  . SER   B 1 227 ? -17.80512 2.95957   -52.88941 1.000 15.48323 ? 227 SER   B OG  1 
ATOM   3708 N  N   . VAL   B 1 228 ? -17.73178 7.78633   -52.63507 1.000 8.03126  ? 228 VAL   B N   1 
ATOM   3709 C  CA  . VAL   B 1 228 ? -18.32677 9.08225   -52.31515 1.000 11.86089 ? 228 VAL   B CA  1 
ATOM   3710 C  C   . VAL   B 1 228 ? -19.51253 9.38001   -53.23140 1.000 10.57238 ? 228 VAL   B C   1 
ATOM   3711 O  O   . VAL   B 1 228 ? -20.63136 9.61665   -52.77307 1.000 10.69039 ? 228 VAL   B O   1 
ATOM   3712 C  CB  . VAL   B 1 228 ? -17.24894 10.18010  -52.39538 1.000 10.80099 ? 228 VAL   B CB  1 
ATOM   3713 C  CG1 . VAL   B 1 228 ? -17.86505 11.56657  -52.33546 1.000 8.56943  ? 228 VAL   B CG1 1 
ATOM   3714 C  CG2 . VAL   B 1 228 ? -16.21460 9.98160   -51.28944 1.000 8.36034  ? 228 VAL   B CG2 1 
ATOM   3715 N  N   . LEU   B 1 229 ? -19.29091 9.32298   -54.53992 1.000 10.63302 ? 229 LEU   B N   1 
ATOM   3716 C  CA  . LEU   B 1 229 ? -20.32802 9.69668   -55.49372 1.000 11.18622 ? 229 LEU   B CA  1 
ATOM   3717 C  C   . LEU   B 1 229 ? -21.47624 8.70629   -55.48392 1.000 11.60290 ? 229 LEU   B C   1 
ATOM   3718 O  O   . LEU   B 1 229 ? -22.64578 9.09846   -55.54843 1.000 10.74087 ? 229 LEU   B O   1 
ATOM   3719 C  CB  . LEU   B 1 229 ? -19.73085 9.75645   -56.89726 1.000 12.66067 ? 229 LEU   B CB  1 
ATOM   3720 C  CG  . LEU   B 1 229 ? -18.81569 10.93759  -57.19736 1.000 14.78102 ? 229 LEU   B CG  1 
ATOM   3721 C  CD1 . LEU   B 1 229 ? -17.86110 10.58414  -58.34567 1.000 10.92030 ? 229 LEU   B CD1 1 
ATOM   3722 C  CD2 . LEU   B 1 229 ? -19.66210 12.12786  -57.52774 1.000 9.65451  ? 229 LEU   B CD2 1 
ATOM   3723 N  N   . GLU   B 1 230 ? -21.14463 7.41488   -55.46815 1.000 11.19814 ? 230 GLU   B N   1 
ATOM   3724 C  CA  . GLU   B 1 230 ? -22.15605 6.36680   -55.48235 1.000 10.62530 ? 230 GLU   B CA  1 
ATOM   3725 C  C   . GLU   B 1 230 ? -23.07465 6.46033   -54.27145 1.000 9.07119  ? 230 GLU   B C   1 
ATOM   3726 O  O   . GLU   B 1 230 ? -24.30007 6.34665   -54.40230 1.000 12.02136 ? 230 GLU   B O   1 
ATOM   3727 C  CB  . GLU   B 1 230 ? -21.46672 5.00834   -55.56018 1.000 10.28344 ? 230 GLU   B CB  1 
ATOM   3728 C  CG  . GLU   B 1 230 ? -20.76527 4.76392   -56.91681 1.000 11.56075 ? 230 GLU   B CG  1 
ATOM   3729 C  CD  . GLU   B 1 230 ? -19.46914 5.57823   -57.09314 1.000 14.68697 ? 230 GLU   B CD  1 
ATOM   3730 O  OE1 . GLU   B 1 230 ? -18.88443 6.01187   -56.07291 1.000 13.33116 ? 230 GLU   B OE1 1 
ATOM   3731 O  OE2 . GLU   B 1 230 ? -19.02437 5.77551   -58.25279 1.000 11.62076 ? 230 GLU   B OE2 1 
ATOM   3732 N  N   . ASN   B 1 231 ? -22.51514 6.68575   -53.08420 1.000 13.31345 ? 231 ASN   B N   1 
ATOM   3733 C  CA  . ASN   B 1 231 ? -23.38352 6.93600   -51.93515 1.000 11.41686 ? 231 ASN   B CA  1 
ATOM   3734 C  C   . ASN   B 1 231 ? -24.25797 8.14551   -52.19505 1.000 9.56128  ? 231 ASN   B C   1 
ATOM   3735 O  O   . ASN   B 1 231 ? -25.46652 8.10487   -51.97061 1.000 10.62136 ? 231 ASN   B O   1 
ATOM   3736 C  CB  . ASN   B 1 231 ? -22.56443 7.13677   -50.66341 1.000 9.49083  ? 231 ASN   B CB  1 
ATOM   3737 C  CG  . ASN   B 1 231 ? -22.15502 5.83470   -50.03271 1.000 12.82709 ? 231 ASN   B CG  1 
ATOM   3738 O  OD1 . ASN   B 1 231 ? -23.00559 5.10015   -49.51349 1.000 14.50166 ? 231 ASN   B OD1 1 
ATOM   3739 N  ND2 . ASN   B 1 231 ? -20.85812 5.53340   -50.06093 1.000 7.57770  ? 231 ASN   B ND2 1 
ATOM   3740 N  N   . HIS   B 1 232 ? -23.67732 9.21227   -52.74159 1.000 12.90335 ? 232 HIS   B N   1 
ATOM   3741 C  CA  . HIS   B 1 232 ? -24.46773 10.41087  -52.99704 1.000 11.29425 ? 232 HIS   B CA  1 
ATOM   3742 C  C   . HIS   B 1 232 ? -25.58705 10.14996  -54.00041 1.000 13.17343 ? 232 HIS   B C   1 
ATOM   3743 O  O   . HIS   B 1 232 ? -26.72509 10.59180  -53.78664 1.000 14.97103 ? 232 HIS   B O   1 
ATOM   3744 C  CB  . HIS   B 1 232 ? -23.56999 11.53865  -53.48303 1.000 17.52731 ? 232 HIS   B CB  1 
ATOM   3745 C  CG  . HIS   B 1 232 ? -24.29522 12.83557  -53.67340 1.000 16.71430 ? 232 HIS   B CG  1 
ATOM   3746 N  ND1 . HIS   B 1 232 ? -24.88100 13.51704  -52.62639 1.000 12.27307 ? 232 HIS   B ND1 1 
ATOM   3747 C  CD2 . HIS   B 1 232 ? -24.54515 13.56281  -54.78889 1.000 9.55788  ? 232 HIS   B CD2 1 
ATOM   3748 C  CE1 . HIS   B 1 232 ? -25.44951 14.61814  -53.08934 1.000 13.27089 ? 232 HIS   B CE1 1 
ATOM   3749 N  NE2 . HIS   B 1 232 ? -25.25798 14.66934  -54.39727 1.000 14.15407 ? 232 HIS   B NE2 1 
ATOM   3750 N  N   . HIS   B 1 233 ? -25.29284 9.43803   -55.10049 1.000 10.35120 ? 233 HIS   B N   1 
ATOM   3751 C  CA  . HIS   B 1 233 ? -26.32567 9.16981   -56.10475 1.000 10.29400 ? 233 HIS   B CA  1 
ATOM   3752 C  C   . HIS   B 1 233 ? -27.51517 8.45369   -55.48142 1.000 15.57446 ? 233 HIS   B C   1 
ATOM   3753 O  O   . HIS   B 1 233 ? -28.67904 8.79143   -55.74805 1.000 15.22085 ? 233 HIS   B O   1 
ATOM   3754 C  CB  . HIS   B 1 233 ? -25.78644 8.30727   -57.23825 1.000 13.05003 ? 233 HIS   B CB  1 
ATOM   3755 C  CG  . HIS   B 1 233 ? -24.55398 8.83535   -57.90514 1.000 13.20382 ? 233 HIS   B CG  1 
ATOM   3756 N  ND1 . HIS   B 1 233 ? -24.35075 10.17328  -58.16259 1.000 12.63038 ? 233 HIS   B ND1 1 
ATOM   3757 C  CD2 . HIS   B 1 233 ? -23.47145 8.18723   -58.39731 1.000 11.16570 ? 233 HIS   B CD2 1 
ATOM   3758 C  CE1 . HIS   B 1 233 ? -23.19159 10.32653  -58.78061 1.000 13.60229 ? 233 HIS   B CE1 1 
ATOM   3759 N  NE2 . HIS   B 1 233 ? -22.63902 9.13561   -58.93665 1.000 11.67218 ? 233 HIS   B NE2 1 
ATOM   3760 N  N   . LEU   B 1 234 ? -27.23102 7.41999   -54.68167 1.000 12.20668 ? 234 LEU   B N   1 
ATOM   3761 C  CA  . LEU   B 1 234 ? -28.27465 6.70101   -53.96199 1.000 12.03046 ? 234 LEU   B CA  1 
ATOM   3762 C  C   . LEU   B 1 234 ? -29.08492 7.64090   -53.09851 1.000 13.10970 ? 234 LEU   B C   1 
ATOM   3763 O  O   . LEU   B 1 234 ? -30.31789 7.65088   -53.16873 1.000 15.34133 ? 234 LEU   B O   1 
ATOM   3764 C  CB  . LEU   B 1 234 ? -27.65541 5.60352   -53.09580 1.000 10.98912 ? 234 LEU   B CB  1 
ATOM   3765 C  CG  . LEU   B 1 234 ? -27.26959 4.29169   -53.76780 1.000 12.67062 ? 234 LEU   B CG  1 
ATOM   3766 C  CD1 . LEU   B 1 234 ? -26.33747 3.51048   -52.87186 1.000 7.44249  ? 234 LEU   B CD1 1 
ATOM   3767 C  CD2 . LEU   B 1 234 ? -28.54131 3.49819   -54.07708 1.000 16.36586 ? 234 LEU   B CD2 1 
ATOM   3768 N  N   . ALA   B 1 235 ? -28.39873 8.42934   -52.25880 1.000 11.38700 ? 235 ALA   B N   1 
ATOM   3769 C  CA  . ALA   B 1 235 ? -29.08939 9.27021   -51.29473 1.000 16.54028 ? 235 ALA   B CA  1 
ATOM   3770 C  C   . ALA   B 1 235 ? -29.99646 10.26808  -51.98963 1.000 17.98382 ? 235 ALA   B C   1 
ATOM   3771 O  O   . ALA   B 1 235 ? -31.03613 10.63542  -51.43854 1.000 17.80617 ? 235 ALA   B O   1 
ATOM   3772 C  CB  . ALA   B 1 235 ? -28.07738 9.99919   -50.38395 1.000 9.51015  ? 235 ALA   B CB  1 
ATOM   3773 N  N   . VAL   B 1 236 ? -29.62900 10.72308  -53.18984 1.000 16.15999 ? 236 VAL   B N   1 
ATOM   3774 C  CA  . VAL   B 1 236 ? -30.48197 11.68288  -53.88707 1.000 17.25870 ? 236 VAL   B CA  1 
ATOM   3775 C  C   . VAL   B 1 236 ? -31.64002 10.95859  -54.55948 1.000 17.64525 ? 236 VAL   B C   1 
ATOM   3776 O  O   . VAL   B 1 236 ? -32.79758 11.38367  -54.46105 1.000 20.97091 ? 236 VAL   B O   1 
ATOM   3777 C  CB  . VAL   B 1 236 ? -29.67251 12.52444  -54.90407 1.000 15.00946 ? 236 VAL   B CB  1 
ATOM   3778 C  CG1 . VAL   B 1 236 ? -30.59188 13.51482  -55.63865 1.000 14.29586 ? 236 VAL   B CG1 1 
ATOM   3779 C  CG2 . VAL   B 1 236 ? -28.53753 13.27619  -54.22197 1.000 13.81606 ? 236 VAL   B CG2 1 
ATOM   3780 N  N   . GLY   B 1 237 ? -31.33685 9.85195   -55.24078 1.000 15.60514 ? 237 GLY   B N   1 
ATOM   3781 C  CA  . GLY   B 1 237 ? -32.37931 9.06793   -55.87870 1.000 16.97209 ? 237 GLY   B CA  1 
ATOM   3782 C  C   . GLY   B 1 237 ? -33.50035 8.69166   -54.93029 1.000 21.27558 ? 237 GLY   B C   1 
ATOM   3783 O  O   . GLY   B 1 237 ? -34.67529 8.73582   -55.29883 1.000 22.41000 ? 237 GLY   B O   1 
ATOM   3784 N  N   . PHE   B 1 238 ? -33.15633 8.34787   -53.68554 1.000 16.53885 ? 238 PHE   B N   1 
ATOM   3785 C  CA  . PHE   B 1 238 ? -34.16796 7.96641   -52.70503 1.000 21.19071 ? 238 PHE   B CA  1 
ATOM   3786 C  C   . PHE   B 1 238 ? -34.82009 9.18608   -52.08526 1.000 20.51039 ? 238 PHE   B C   1 
ATOM   3787 O  O   . PHE   B 1 238 ? -36.03585 9.19801   -51.85844 1.000 22.80935 ? 238 PHE   B O   1 
ATOM   3788 C  CB  . PHE   B 1 238 ? -33.54651 7.10655   -51.59729 1.000 20.31038 ? 238 PHE   B CB  1 
ATOM   3789 C  CG  . PHE   B 1 238 ? -33.31745 5.68274   -51.98456 1.000 11.73755 ? 238 PHE   B CG  1 
ATOM   3790 C  CD1 . PHE   B 1 238 ? -34.38745 4.83045   -52.21247 1.000 15.63551 ? 238 PHE   B CD1 1 
ATOM   3791 C  CD2 . PHE   B 1 238 ? -32.03895 5.18181   -52.08429 1.000 17.00420 ? 238 PHE   B CD2 1 
ATOM   3792 C  CE1 . PHE   B 1 238 ? -34.17154 3.51460   -52.56183 1.000 18.01394 ? 238 PHE   B CE1 1 
ATOM   3793 C  CE2 . PHE   B 1 238 ? -31.81260 3.85390   -52.41928 1.000 15.43770 ? 238 PHE   B CE2 1 
ATOM   3794 C  CZ  . PHE   B 1 238 ? -32.87632 3.02484   -52.66860 1.000 16.28968 ? 238 PHE   B CZ  1 
ATOM   3795 N  N   . LYS   B 1 239 ? -34.00882 10.19665  -51.76326 1.000 23.30556 ? 239 LYS   B N   1 
ATOM   3796 C  CA  . LYS   B 1 239 ? -34.52133 11.44795  -51.21692 1.000 23.97999 ? 239 LYS   B CA  1 
ATOM   3797 C  C   . LYS   B 1 239 ? -35.64729 11.99880  -52.07695 1.000 26.84496 ? 239 LYS   B C   1 
ATOM   3798 O  O   . LYS   B 1 239 ? -36.65541 12.49424  -51.55846 1.000 31.91060 ? 239 LYS   B O   1 
ATOM   3799 C  CB  . LYS   B 1 239 ? -33.38282 12.46140  -51.11684 1.000 24.67744 ? 239 LYS   B CB  1 
ATOM   3800 C  CG  . LYS   B 1 239 ? -33.73555 13.78814  -50.49371 1.000 27.91055 ? 239 LYS   B CG  1 
ATOM   3801 C  CD  . LYS   B 1 239 ? -34.05381 13.63638  -49.02550 1.000 35.29415 ? 239 LYS   B CD  1 
ATOM   3802 C  CE  . LYS   B 1 239 ? -34.16261 14.99496  -48.34125 1.000 33.34293 ? 239 LYS   B CE  1 
ATOM   3803 N  NZ  . LYS   B 1 239 ? -34.90439 14.87884  -47.05413 1.000 35.37008 ? 239 LYS   B NZ  1 
ATOM   3804 N  N   . LEU   B 1 240 ? -35.50484 11.88071  -53.39808 1.000 26.11327 ? 240 LEU   B N   1 
ATOM   3805 C  CA  . LEU   B 1 240 ? -36.46408 12.47984  -54.31808 1.000 30.53713 ? 240 LEU   B CA  1 
ATOM   3806 C  C   . LEU   B 1 240 ? -37.83129 11.82600  -54.22037 1.000 29.82070 ? 240 LEU   B C   1 
ATOM   3807 O  O   . LEU   B 1 240 ? -38.84313 12.48206  -54.48152 1.000 40.90732 ? 240 LEU   B O   1 
ATOM   3808 C  CB  . LEU   B 1 240 ? -35.93459 12.39355  -55.74706 1.000 28.32186 ? 240 LEU   B CB  1 
ATOM   3809 C  CG  . LEU   B 1 240 ? -34.73138 13.30050  -56.03732 1.000 28.05262 ? 240 LEU   B CG  1 
ATOM   3810 C  CD1 . LEU   B 1 240 ? -34.23629 13.10081  -57.47324 1.000 21.50003 ? 240 LEU   B CD1 1 
ATOM   3811 C  CD2 . LEU   B 1 240 ? -35.09088 14.75435  -55.77324 1.000 24.70134 ? 240 LEU   B CD2 1 
ATOM   3812 N  N   . LEU   B 1 241 ? -37.88682 10.54610  -53.85074 1.000 32.80850 ? 241 LEU   B N   1 
ATOM   3813 C  CA  . LEU   B 1 241 ? -39.16862 9.86794   -53.68499 1.000 33.21599 ? 241 LEU   B CA  1 
ATOM   3814 C  C   . LEU   B 1 241 ? -40.04933 10.52649  -52.63879 1.000 35.89099 ? 241 LEU   B C   1 
ATOM   3815 O  O   . LEU   B 1 241 ? -41.23482 10.19782  -52.56967 1.000 44.80009 ? 241 LEU   B O   1 
ATOM   3816 C  CB  . LEU   B 1 241 ? -38.95558 8.40073   -53.30220 1.000 34.79736 ? 241 LEU   B CB  1 
ATOM   3817 C  CG  . LEU   B 1 241 ? -38.30648 7.45970   -54.32021 1.000 32.93856 ? 241 LEU   B CG  1 
ATOM   3818 C  CD1 . LEU   B 1 241 ? -37.88287 6.17135   -53.63669 1.000 25.97709 ? 241 LEU   B CD1 1 
ATOM   3819 C  CD2 . LEU   B 1 241 ? -39.24244 7.16741   -55.47732 1.000 25.41047 ? 241 LEU   B CD2 1 
ATOM   3820 N  N   . GLN   B 1 242 ? -39.50381 11.43675  -51.82927 1.000 33.37822 ? 242 GLN   B N   1 
ATOM   3821 C  CA  . GLN   B 1 242 ? -40.23544 12.08318  -50.75488 1.000 29.91323 ? 242 GLN   B CA  1 
ATOM   3822 C  C   . GLN   B 1 242 ? -40.77325 13.46013  -51.12811 1.000 45.48882 ? 242 GLN   B C   1 
ATOM   3823 O  O   . GLN   B 1 242 ? -41.52092 14.05090  -50.33673 1.000 34.36475 ? 242 GLN   B O   1 
ATOM   3824 C  CB  . GLN   B 1 242 ? -39.34332 12.20875  -49.51950 1.000 33.00699 ? 242 GLN   B CB  1 
ATOM   3825 C  CG  . GLN   B 1 242 ? -39.00786 10.87913  -48.89548 1.000 34.81598 ? 242 GLN   B CG  1 
ATOM   3826 C  CD  . GLN   B 1 242 ? -38.00991 11.00412  -47.77819 1.000 39.63742 ? 242 GLN   B CD  1 
ATOM   3827 O  OE1 . GLN   B 1 242 ? -37.66188 12.11158  -47.36210 1.000 41.86364 ? 242 GLN   B OE1 1 
ATOM   3828 N  NE2 . GLN   B 1 242 ? -37.53277 9.86175   -47.28243 1.000 36.39903 ? 242 GLN   B NE2 1 
ATOM   3829 N  N   . GLU   B 1 243 ? -40.40984 13.99234  -52.29074 1.000 43.43217 ? 243 GLU   B N   1 
ATOM   3830 C  CA  . GLU   B 1 243 ? -41.04632 15.21950  -52.73663 1.000 46.17572 ? 243 GLU   B CA  1 
ATOM   3831 C  C   . GLU   B 1 243 ? -42.44368 14.88813  -53.26142 1.000 46.59961 ? 243 GLU   B C   1 
ATOM   3832 O  O   . GLU   B 1 243 ? -42.73338 13.74845  -53.64044 1.000 45.34447 ? 243 GLU   B O   1 
ATOM   3833 C  CB  . GLU   B 1 243 ? -40.18188 15.91941  -53.79204 1.000 51.40918 ? 243 GLU   B CB  1 
ATOM   3834 C  CG  . GLU   B 1 243 ? -38.71991 16.11843  -53.35962 1.000 40.97491 ? 243 GLU   B CG  1 
ATOM   3835 C  CD  . GLU   B 1 243 ? -38.39344 17.54128  -52.92282 1.000 53.20949 ? 243 GLU   B CD  1 
ATOM   3836 O  OE1 . GLU   B 1 243 ? -37.75362 18.26912  -53.71240 1.000 55.84313 ? 243 GLU   B OE1 1 
ATOM   3837 O  OE2 . GLU   B 1 243 ? -38.75806 17.93432  -51.79244 1.000 55.68928 ? 243 GLU   B OE2 1 
ATOM   3838 N  N   . GLU   B 1 244 ? -43.31846 15.89448  -53.26946 1.000 52.00321 ? 244 GLU   B N   1 
ATOM   3839 C  CA  . GLU   B 1 244 ? -44.74923 15.61862  -53.34749 1.000 50.56534 ? 244 GLU   B CA  1 
ATOM   3840 C  C   . GLU   B 1 244 ? -45.12414 14.91157  -54.65114 1.000 42.26174 ? 244 GLU   B C   1 
ATOM   3841 O  O   . GLU   B 1 244 ? -44.66329 15.27098  -55.73735 1.000 40.52677 ? 244 GLU   B O   1 
ATOM   3842 C  CB  . GLU   B 1 244 ? -45.55482 16.91297  -53.15184 1.000 55.12565 ? 244 GLU   B CB  1 
ATOM   3843 C  CG  . GLU   B 1 244 ? -45.80698 17.77362  -54.37980 1.000 62.26272 ? 244 GLU   B CG  1 
ATOM   3844 C  CD  . GLU   B 1 244 ? -47.00419 18.69333  -54.18250 1.000 68.44143 ? 244 GLU   B CD  1 
ATOM   3845 O  OE1 . GLU   B 1 244 ? -47.15090 19.67881  -54.95077 1.000 64.92796 ? 244 GLU   B OE1 1 
ATOM   3846 O  OE2 . GLU   B 1 244 ? -47.79757 18.42090  -53.24741 1.000 65.67649 ? 244 GLU   B OE2 1 
ATOM   3847 N  N   . ASN   B 1 245 ? -45.95163 13.87381  -54.51084 1.000 48.29716 ? 245 ASN   B N   1 
ATOM   3848 C  CA  . ASN   B 1 245 ? -46.35272 12.95317  -55.57964 1.000 40.38961 ? 245 ASN   B CA  1 
ATOM   3849 C  C   . ASN   B 1 245 ? -45.15087 12.45954  -56.38522 1.000 46.64788 ? 245 ASN   B C   1 
ATOM   3850 O  O   . ASN   B 1 245 ? -45.09489 12.60515  -57.60402 1.000 45.95416 ? 245 ASN   B O   1 
ATOM   3851 C  CB  . ASN   B 1 245 ? -47.40342 13.58918  -56.49832 1.000 42.26341 ? 245 ASN   B CB  1 
ATOM   3852 C  CG  . ASN   B 1 245 ? -48.07913 12.57028  -57.42587 1.000 51.56963 ? 245 ASN   B CG  1 
ATOM   3853 O  OD1 . ASN   B 1 245 ? -48.15543 11.37368  -57.12781 1.000 46.22634 ? 245 ASN   B OD1 1 
ATOM   3854 N  ND2 . ASN   B 1 245 ? -48.58108 13.05480  -58.55580 1.000 57.12632 ? 245 ASN   B ND2 1 
ATOM   3855 N  N   . CYS   B 1 246 ? -44.17754 11.85476  -55.67663 1.000 44.35645 ? 246 CYS   B N   1 
ATOM   3856 C  CA  . CYS   B 1 246 ? -43.06604 11.16054  -56.32374 1.000 33.53461 ? 246 CYS   B CA  1 
ATOM   3857 C  C   . CYS   B 1 246 ? -42.84144 9.73841   -55.82000 1.000 41.59224 ? 246 CYS   B C   1 
ATOM   3858 O  O   . CYS   B 1 246 ? -41.95676 9.05332   -56.34819 1.000 31.40342 ? 246 CYS   B O   1 
ATOM   3859 C  CB  . CYS   B 1 246 ? -41.74758 11.92913  -56.15174 1.000 33.80314 ? 246 CYS   B CB  1 
ATOM   3860 S  SG  . CYS   B 1 246 ? -41.67935 13.57786  -56.85111 1.000 34.65641 ? 246 CYS   B SG  1 
ATOM   3861 N  N   . ASP   B 1 247 ? -43.59794 9.27556   -54.81891 1.000 38.82591 ? 247 ASP   B N   1 
ATOM   3862 C  CA  . ASP   B 1 247 ? -43.35075 7.97275   -54.19388 1.000 39.86800 ? 247 ASP   B CA  1 
ATOM   3863 C  C   . ASP   B 1 247 ? -43.88187 6.86905   -55.10633 1.000 34.74453 ? 247 ASP   B C   1 
ATOM   3864 O  O   . ASP   B 1 247 ? -44.96208 6.31222   -54.90679 1.000 39.90823 ? 247 ASP   B O   1 
ATOM   3865 C  CB  . ASP   B 1 247 ? -43.98392 7.90980   -52.80643 1.000 35.50044 ? 247 ASP   B CB  1 
ATOM   3866 C  CG  . ASP   B 1 247 ? -43.52876 6.68471   -52.00213 1.000 48.46898 ? 247 ASP   B CG  1 
ATOM   3867 O  OD1 . ASP   B 1 247 ? -43.23524 5.62052   -52.60506 1.000 42.04543 ? 247 ASP   B OD1 1 
ATOM   3868 O  OD2 . ASP   B 1 247 ? -43.45977 6.78937   -50.75572 1.000 50.81541 ? 247 ASP   B OD2 1 
ATOM   3869 N  N   . ILE   B 1 248 ? -43.08650 6.52575   -56.11966 1.000 25.31594 ? 248 ILE   B N   1 
ATOM   3870 C  CA  . ILE   B 1 248 ? -43.51279 5.51412   -57.07407 1.000 28.88681 ? 248 ILE   B CA  1 
ATOM   3871 C  C   . ILE   B 1 248 ? -43.55165 4.12715   -56.46429 1.000 34.57774 ? 248 ILE   B C   1 
ATOM   3872 O  O   . ILE   B 1 248 ? -44.02457 3.19006   -57.10866 1.000 30.63813 ? 248 ILE   B O   1 
ATOM   3873 C  CB  . ILE   B 1 248 ? -42.60401 5.50558   -58.32240 1.000 27.73271 ? 248 ILE   B CB  1 
ATOM   3874 C  CG1 . ILE   B 1 248 ? -41.19415 5.05174   -57.96103 1.000 31.83790 ? 248 ILE   B CG1 1 
ATOM   3875 C  CG2 . ILE   B 1 248 ? -42.57214 6.89391   -58.97416 1.000 35.58027 ? 248 ILE   B CG2 1 
ATOM   3876 C  CD1 . ILE   B 1 248 ? -40.33974 4.74535   -59.15246 1.000 29.98034 ? 248 ILE   B CD1 1 
ATOM   3877 N  N   . PHE   B 1 249 ? -43.05056 3.96475   -55.24415 1.000 35.53231 ? 249 PHE   B N   1 
ATOM   3878 C  CA  . PHE   B 1 249 ? -43.10024 2.68463   -54.56005 1.000 37.53053 ? 249 PHE   B CA  1 
ATOM   3879 C  C   . PHE   B 1 249 ? -44.18535 2.65828   -53.49190 1.000 36.53647 ? 249 PHE   B C   1 
ATOM   3880 O  O   . PHE   B 1 249 ? -44.12850 1.83905   -52.56497 1.000 32.50671 ? 249 PHE   B O   1 
ATOM   3881 C  CB  . PHE   B 1 249 ? -41.72391 2.37156   -53.97906 1.000 40.09539 ? 249 PHE   B CB  1 
ATOM   3882 C  CG  . PHE   B 1 249 ? -40.63542 2.34209   -55.02011 1.000 36.26098 ? 249 PHE   B CG  1 
ATOM   3883 C  CD1 . PHE   B 1 249 ? -40.76488 1.54230   -56.15177 1.000 39.25153 ? 249 PHE   B CD1 1 
ATOM   3884 C  CD2 . PHE   B 1 249 ? -39.50603 3.13801   -54.89161 1.000 24.30205 ? 249 PHE   B CD2 1 
ATOM   3885 C  CE1 . PHE   B 1 249 ? -39.77701 1.51796   -57.12525 1.000 32.58486 ? 249 PHE   B CE1 1 
ATOM   3886 C  CE2 . PHE   B 1 249 ? -38.52285 3.12722   -55.86022 1.000 29.76550 ? 249 PHE   B CE2 1 
ATOM   3887 C  CZ  . PHE   B 1 249 ? -38.65243 2.31431   -56.97813 1.000 34.61780 ? 249 PHE   B CZ  1 
ATOM   3888 N  N   . GLN   B 1 250 ? -45.18342 3.53582   -53.63381 1.000 37.06235 ? 250 GLN   B N   1 
ATOM   3889 C  CA  . GLN   B 1 250 ? -46.20070 3.74756   -52.61060 1.000 39.28242 ? 250 GLN   B CA  1 
ATOM   3890 C  C   . GLN   B 1 250 ? -47.08437 2.52939   -52.41093 1.000 37.05910 ? 250 GLN   B C   1 
ATOM   3891 O  O   . GLN   B 1 250 ? -47.53475 2.27848   -51.29121 1.000 43.82166 ? 250 GLN   B O   1 
ATOM   3892 C  CB  . GLN   B 1 250 ? -47.06653 4.94613   -52.98186 1.000 35.71454 ? 250 GLN   B CB  1 
ATOM   3893 C  CG  . GLN   B 1 250 ? -47.68263 4.82894   -54.37613 1.000 42.30316 ? 250 GLN   B CG  1 
ATOM   3894 C  CD  . GLN   B 1 250 ? -48.53726 6.02981   -54.74314 1.000 43.20073 ? 250 GLN   B CD  1 
ATOM   3895 O  OE1 . GLN   B 1 250 ? -48.08464 7.17626   -54.68634 1.000 46.63135 ? 250 GLN   B OE1 1 
ATOM   3896 N  NE2 . GLN   B 1 250 ? -49.78577 5.77067   -55.11377 1.000 38.66406 ? 250 GLN   B NE2 1 
ATOM   3897 N  N   . ASN   B 1 251 ? -47.35611 1.76997   -53.46732 1.000 34.43418 ? 251 ASN   B N   1 
ATOM   3898 C  CA  . ASN   B 1 251 ? -48.22893 0.61178   -53.36705 1.000 42.61178 ? 251 ASN   B CA  1 
ATOM   3899 C  C   . ASN   B 1 251 ? -47.44517 -0.69367  -53.31576 1.000 42.64983 ? 251 ASN   B C   1 
ATOM   3900 O  O   . ASN   B 1 251 ? -48.01465 -1.76989  -53.53232 1.000 44.26713 ? 251 ASN   B O   1 
ATOM   3901 C  CB  . ASN   B 1 251 ? -49.23588 0.62493   -54.51587 1.000 36.56348 ? 251 ASN   B CB  1 
ATOM   3902 C  CG  . ASN   B 1 251 ? -50.07561 1.88336   -54.51405 1.000 44.33512 ? 251 ASN   B CG  1 
ATOM   3903 O  OD1 . ASN   B 1 251 ? -50.50339 2.35199   -53.45827 1.000 40.85904 ? 251 ASN   B OD1 1 
ATOM   3904 N  ND2 . ASN   B 1 251 ? -50.29400 2.45577   -55.69153 1.000 49.08281 ? 251 ASN   B ND2 1 
ATOM   3905 N  N   . LEU   B 1 252 ? -46.14496 -0.61249  -53.05131 1.000 40.05213 ? 252 LEU   B N   1 
ATOM   3906 C  CA  . LEU   B 1 252 ? -45.36198 -1.78414  -52.70954 1.000 37.90191 ? 252 LEU   B CA  1 
ATOM   3907 C  C   . LEU   B 1 252 ? -45.54116 -2.10138  -51.23451 1.000 35.50651 ? 252 LEU   B C   1 
ATOM   3908 O  O   . LEU   B 1 252 ? -45.76153 -1.21052  -50.40830 1.000 36.89535 ? 252 LEU   B O   1 
ATOM   3909 C  CB  . LEU   B 1 252 ? -43.87703 -1.55320  -52.99564 1.000 37.86340 ? 252 LEU   B CB  1 
ATOM   3910 C  CG  . LEU   B 1 252 ? -43.33116 -2.02815  -54.33593 1.000 44.07713 ? 252 LEU   B CG  1 
ATOM   3911 C  CD1 . LEU   B 1 252 ? -43.80147 -1.09182  -55.44185 1.000 44.89253 ? 252 LEU   B CD1 1 
ATOM   3912 C  CD2 . LEU   B 1 252 ? -41.81088 -2.12347  -54.28796 1.000 35.93133 ? 252 LEU   B CD2 1 
ATOM   3913 N  N   . THR   B 1 253 ? -45.41421 -3.37778  -50.89791 1.000 35.32089 ? 253 THR   B N   1 
ATOM   3914 C  CA  . THR   B 1 253 ? -45.50486 -3.72817  -49.49576 1.000 32.64310 ? 253 THR   B CA  1 
ATOM   3915 C  C   . THR   B 1 253 ? -44.25054 -3.27354  -48.75067 1.000 45.75176 ? 253 THR   B C   1 
ATOM   3916 O  O   . THR   B 1 253 ? -43.22451 -2.90127  -49.34317 1.000 40.30347 ? 253 THR   B O   1 
ATOM   3917 C  CB  . THR   B 1 253 ? -45.71419 -5.22679  -49.32232 1.000 33.73323 ? 253 THR   B CB  1 
ATOM   3918 O  OG1 . THR   B 1 253 ? -44.49848 -5.92154  -49.60977 1.000 35.73597 ? 253 THR   B OG1 1 
ATOM   3919 C  CG2 . THR   B 1 253 ? -46.80950 -5.72078  -50.26395 1.000 34.89944 ? 253 THR   B CG2 1 
ATOM   3920 N  N   . LYS   B 1 254 ? -44.37170 -3.28134  -47.42104 1.000 48.52620 ? 254 LYS   B N   1 
ATOM   3921 C  CA  . LYS   B 1 254 ? -43.25426 -2.96729  -46.54106 1.000 44.73282 ? 254 LYS   B CA  1 
ATOM   3922 C  C   . LYS   B 1 254 ? -42.02828 -3.78169  -46.91063 1.000 38.08977 ? 254 LYS   B C   1 
ATOM   3923 O  O   . LYS   B 1 254 ? -40.91917 -3.25085  -47.00971 1.000 31.60856 ? 254 LYS   B O   1 
ATOM   3924 C  CB  . LYS   B 1 254 ? -43.65555 -3.24925  -45.09266 1.000 47.87262 ? 254 LYS   B CB  1 
ATOM   3925 C  CG  . LYS   B 1 254 ? -43.56206 -2.06682  -44.16840 1.000 54.30137 ? 254 LYS   B CG  1 
ATOM   3926 C  CD  . LYS   B 1 254 ? -42.12721 -1.68111  -43.92676 1.000 60.02891 ? 254 LYS   B CD  1 
ATOM   3927 C  CE  . LYS   B 1 254 ? -42.03489 -0.59932  -42.86504 1.000 61.57093 ? 254 LYS   B CE  1 
ATOM   3928 N  NZ  . LYS   B 1 254 ? -40.64201 -0.09648  -42.73592 1.000 55.82568 ? 254 LYS   B NZ  1 
ATOM   3929 N  N   . LYS   B 1 255 ? -42.21681 -5.08337  -47.12445 1.000 38.78996 ? 255 LYS   B N   1 
ATOM   3930 C  CA  . LYS   B 1 255 ? -41.07377 -5.95754  -47.34218 1.000 40.39790 ? 255 LYS   B CA  1 
ATOM   3931 C  C   . LYS   B 1 255 ? -40.45419 -5.71661  -48.71055 1.000 36.47549 ? 255 LYS   B C   1 
ATOM   3932 O  O   . LYS   B 1 255 ? -39.22609 -5.71129  -48.84503 1.000 35.41880 ? 255 LYS   B O   1 
ATOM   3933 C  CB  . LYS   B 1 255 ? -41.49486 -7.41701  -47.18044 1.000 35.57882 ? 255 LYS   B CB  1 
ATOM   3934 C  CG  . LYS   B 1 255 ? -40.46896 -8.26523  -46.45163 1.000 46.74919 ? 255 LYS   B CG  1 
ATOM   3935 C  CD  . LYS   B 1 255 ? -40.29083 -7.82534  -44.99701 1.000 52.00515 ? 255 LYS   B CD  1 
ATOM   3936 C  CE  . LYS   B 1 255 ? -41.55148 -8.04865  -44.16315 1.000 54.82371 ? 255 LYS   B CE  1 
ATOM   3937 N  NZ  . LYS   B 1 255 ? -41.29215 -7.92359  -42.69244 1.000 49.61002 ? 255 LYS   B NZ  1 
ATOM   3938 N  N   . GLN   B 1 256 ? -41.29097 -5.51664  -49.73399 1.000 34.25276 ? 256 GLN   B N   1 
ATOM   3939 C  CA  . GLN   B 1 256 ? -40.78823 -5.23614  -51.07665 1.000 37.59451 ? 256 GLN   B CA  1 
ATOM   3940 C  C   . GLN   B 1 256 ? -39.99568 -3.93113  -51.10721 1.000 33.96237 ? 256 GLN   B C   1 
ATOM   3941 O  O   . GLN   B 1 256 ? -38.88364 -3.88413  -51.64608 1.000 25.83962 ? 256 GLN   B O   1 
ATOM   3942 C  CB  . GLN   B 1 256 ? -41.94698 -5.16568  -52.07197 1.000 31.68147 ? 256 GLN   B CB  1 
ATOM   3943 C  CG  . GLN   B 1 256 ? -42.83828 -6.39571  -52.14629 1.000 37.59035 ? 256 GLN   B CG  1 
ATOM   3944 C  CD  . GLN   B 1 256 ? -44.11934 -6.11977  -52.93274 1.000 31.55145 ? 256 GLN   B CD  1 
ATOM   3945 O  OE1 . GLN   B 1 256 ? -44.78131 -5.09400  -52.73295 1.000 26.14070 ? 256 GLN   B OE1 1 
ATOM   3946 N  NE2 . GLN   B 1 256 ? -44.46213 -7.02877  -53.83865 1.000 28.53159 ? 256 GLN   B NE2 1 
ATOM   3947 N  N   . ARG   B 1 257 ? -40.56933 -2.85066  -50.55336 1.000 33.67724 ? 257 ARG   B N   1 
ATOM   3948 C  CA  . ARG   B 1 257 ? -39.84613 -1.58375  -50.47381 1.000 30.14733 ? 257 ARG   B CA  1 
ATOM   3949 C  C   . ARG   B 1 257 ? -38.49062 -1.77662  -49.80985 1.000 33.54861 ? 257 ARG   B C   1 
ATOM   3950 O  O   . ARG   B 1 257 ? -37.48739 -1.18120  -50.22589 1.000 28.39821 ? 257 ARG   B O   1 
ATOM   3951 C  CB  . ARG   B 1 257 ? -40.66524 -0.54416  -49.70557 1.000 38.99871 ? 257 ARG   B CB  1 
ATOM   3952 C  CG  . ARG   B 1 257 ? -41.69771 0.20212   -50.54209 1.000 43.29207 ? 257 ARG   B CG  1 
ATOM   3953 C  CD  . ARG   B 1 257 ? -42.58490 1.07473   -49.66294 1.000 39.40836 ? 257 ARG   B CD  1 
ATOM   3954 N  NE  . ARG   B 1 257 ? -41.88561 2.25775   -49.17131 1.000 41.81357 ? 257 ARG   B NE  1 
ATOM   3955 C  CZ  . ARG   B 1 257 ? -42.34858 3.49818   -49.29876 1.000 45.06736 ? 257 ARG   B CZ  1 
ATOM   3956 N  NH1 . ARG   B 1 257 ? -43.50723 3.71367   -49.90217 1.000 47.27849 ? 257 ARG   B NH1 1 
ATOM   3957 N  NH2 . ARG   B 1 257 ? -41.66221 4.52587   -48.82126 1.000 51.49263 ? 257 ARG   B NH2 1 
ATOM   3958 N  N   . GLN   B 1 258 ? -38.44204 -2.63696  -48.79102 1.000 33.88461 ? 258 GLN   B N   1 
ATOM   3959 C  CA  . GLN   B 1 258 ? -37.19593 -2.89559  -48.07836 1.000 31.49290 ? 258 GLN   B CA  1 
ATOM   3960 C  C   . GLN   B 1 258 ? -36.26121 -3.77194  -48.90268 1.000 30.00637 ? 258 GLN   B C   1 
ATOM   3961 O  O   . GLN   B 1 258 ? -35.04146 -3.55521  -48.90918 1.000 21.07581 ? 258 GLN   B O   1 
ATOM   3962 C  CB  . GLN   B 1 258 ? -37.51086 -3.54400  -46.72983 1.000 35.23027 ? 258 GLN   B CB  1 
ATOM   3963 C  CG  . GLN   B 1 258 ? -36.32107 -3.93071  -45.87209 1.000 31.11229 ? 258 GLN   B CG  1 
ATOM   3964 C  CD  . GLN   B 1 258 ? -36.72299 -4.90347  -44.76940 1.000 46.19492 ? 258 GLN   B CD  1 
ATOM   3965 O  OE1 . GLN   B 1 258 ? -37.90429 -4.99770  -44.40690 1.000 43.72354 ? 258 GLN   B OE1 1 
ATOM   3966 N  NE2 . GLN   B 1 258 ? -35.74597 -5.64519  -44.24232 1.000 45.10607 ? 258 GLN   B NE2 1 
ATOM   3967 N  N   . SER   B 1 259 ? -36.80972 -4.77332  -49.60029 1.000 24.06830 ? 259 SER   B N   1 
ATOM   3968 C  CA  . SER   B 1 259 ? -35.95827 -5.61541  -50.43083 1.000 25.60761 ? 259 SER   B CA  1 
ATOM   3969 C  C   . SER   B 1 259 ? -35.46266 -4.84643  -51.64250 1.000 21.11884 ? 259 SER   B C   1 
ATOM   3970 O  O   . SER   B 1 259 ? -34.31202 -5.00158  -52.05231 1.000 19.41669 ? 259 SER   B O   1 
ATOM   3971 C  CB  . SER   B 1 259 ? -36.70024 -6.87830  -50.87310 1.000 30.99265 ? 259 SER   B CB  1 
ATOM   3972 O  OG  . SER   B 1 259 ? -35.84868 -7.67509  -51.68801 1.000 30.12676 ? 259 SER   B OG  1 
ATOM   3973 N  N   . LEU   B 1 260 ? -36.32912 -4.01951  -52.22433 1.000 23.45403 ? 260 LEU   B N   1 
ATOM   3974 C  CA  . LEU   B 1 260 ? -35.92203 -3.14067  -53.30792 1.000 27.47688 ? 260 LEU   B CA  1 
ATOM   3975 C  C   . LEU   B 1 260 ? -34.78155 -2.22351  -52.87704 1.000 21.16231 ? 260 LEU   B C   1 
ATOM   3976 O  O   . LEU   B 1 260 ? -33.74602 -2.14520  -53.55075 1.000 18.61038 ? 260 LEU   B O   1 
ATOM   3977 C  CB  . LEU   B 1 260 ? -37.12155 -2.32058  -53.77218 1.000 26.53463 ? 260 LEU   B CB  1 
ATOM   3978 C  CG  . LEU   B 1 260 ? -36.80445 -1.30858  -54.86870 1.000 31.77943 ? 260 LEU   B CG  1 
ATOM   3979 C  CD1 . LEU   B 1 260 ? -36.26544 -2.04760  -56.04029 1.000 27.06446 ? 260 LEU   B CD1 1 
ATOM   3980 C  CD2 . LEU   B 1 260 ? -38.06687 -0.60894  -55.25790 1.000 34.54660 ? 260 LEU   B CD2 1 
ATOM   3981 N  N   . ARG   B 1 261 ? -34.95969 -1.51776  -51.75314 1.000 19.93610 ? 261 ARG   B N   1 
ATOM   3982 C  CA  . ARG   B 1 261 ? -33.95044 -0.55956  -51.31102 1.000 22.44602 ? 261 ARG   B CA  1 
ATOM   3983 C  C   . ARG   B 1 261 ? -32.58776 -1.22371  -51.22735 1.000 16.16692 ? 261 ARG   B C   1 
ATOM   3984 O  O   . ARG   B 1 261 ? -31.59909 -0.69848  -51.75310 1.000 17.15876 ? 261 ARG   B O   1 
ATOM   3985 C  CB  . ARG   B 1 261 ? -34.34833 0.06027   -49.96440 1.000 20.33625 ? 261 ARG   B CB  1 
ATOM   3986 C  CG  . ARG   B 1 261 ? -33.27448 0.96151   -49.35293 1.000 18.36736 ? 261 ARG   B CG  1 
ATOM   3987 C  CD  . ARG   B 1 261 ? -33.83628 1.82988   -48.22493 1.000 24.23641 ? 261 ARG   B CD  1 
ATOM   3988 N  NE  . ARG   B 1 261 ? -32.78825 2.41748   -47.38969 1.000 18.39916 ? 261 ARG   B NE  1 
ATOM   3989 C  CZ  . ARG   B 1 261 ? -32.14967 3.55156   -47.66355 1.000 15.64443 ? 261 ARG   B CZ  1 
ATOM   3990 N  NH1 . ARG   B 1 261 ? -32.46331 4.23867   -48.74930 1.000 17.21676 ? 261 ARG   B NH1 1 
ATOM   3991 N  NH2 . ARG   B 1 261 ? -31.20378 4.00465   -46.84236 1.000 12.12393 ? 261 ARG   B NH2 1 
ATOM   3992 N  N   . LYS   B 1 262 ? -32.53622 -2.42286  -50.62959 1.000 19.20110 ? 262 LYS   B N   1 
ATOM   3993 C  CA  . LYS   B 1 262 ? -31.26299 -3.12095  -50.46516 1.000 20.56841 ? 262 LYS   B CA  1 
ATOM   3994 C  C   . LYS   B 1 262 ? -30.65192 -3.48261  -51.80940 1.000 18.94865 ? 262 LYS   B C   1 
ATOM   3995 O  O   . LYS   B 1 262 ? -29.44419 -3.31703  -52.01385 1.000 16.91305 ? 262 LYS   B O   1 
ATOM   3996 C  CB  . LYS   B 1 262 ? -31.42679 -4.38171  -49.61342 1.000 18.96767 ? 262 LYS   B CB  1 
ATOM   3997 C  CG  . LYS   B 1 262 ? -30.21578 -5.28676  -49.73610 1.000 19.48944 ? 262 LYS   B CG  1 
ATOM   3998 C  CD  . LYS   B 1 262 ? -30.21538 -6.47986  -48.81666 1.000 27.95936 ? 262 LYS   B CD  1 
ATOM   3999 C  CE  . LYS   B 1 262 ? -28.76889 -6.80860  -48.44367 1.000 34.62580 ? 262 LYS   B CE  1 
ATOM   4000 N  NZ  . LYS   B 1 262 ? -28.23275 -5.75745  -47.50862 1.000 27.43041 ? 262 LYS   B NZ  1 
ATOM   4001 N  N   . MET   B 1 263 ? -31.46594 -3.97783  -52.74170 1.000 19.27420 ? 263 MET   B N   1 
ATOM   4002 C  CA  . MET   B 1 263 ? -30.92398 -4.33474  -54.04800 1.000 22.60260 ? 263 MET   B CA  1 
ATOM   4003 C  C   . MET   B 1 263 ? -30.39307 -3.10650  -54.77504 1.000 18.72020 ? 263 MET   B C   1 
ATOM   4004 O  O   . MET   B 1 263 ? -29.30599 -3.14635  -55.36071 1.000 19.03838 ? 263 MET   B O   1 
ATOM   4005 C  CB  . MET   B 1 263 ? -31.98863 -5.04309  -54.88675 1.000 27.41458 ? 263 MET   B CB  1 
ATOM   4006 C  CG  . MET   B 1 263 ? -32.34794 -6.45158  -54.38585 1.000 29.61061 ? 263 MET   B CG  1 
ATOM   4007 S  SD  . MET   B 1 263 ? -33.52782 -7.28201  -55.47384 1.000 28.47018 ? 263 MET   B SD  1 
ATOM   4008 C  CE  . MET   B 1 263 ? -34.97384 -6.22742  -55.44537 1.000 22.42228 ? 263 MET   B CE  1 
ATOM   4009 N  N   . VAL   B 1 264 ? -31.13952 -1.99998  -54.72580 1.000 19.52111 ? 264 VAL   B N   1 
ATOM   4010 C  CA  . VAL   B 1 264 ? -30.72929 -0.77369  -55.40799 1.000 16.47408 ? 264 VAL   B CA  1 
ATOM   4011 C  C   . VAL   B 1 264 ? -29.40639 -0.27101  -54.85245 1.000 17.34430 ? 264 VAL   B C   1 
ATOM   4012 O  O   . VAL   B 1 264 ? -28.49158 0.07023   -55.61475 1.000 12.92916 ? 264 VAL   B O   1 
ATOM   4013 C  CB  . VAL   B 1 264 ? -31.82778 0.29458   -55.29801 1.000 18.48007 ? 264 VAL   B CB  1 
ATOM   4014 C  CG1 . VAL   B 1 264 ? -31.29523 1.63974   -55.77416 1.000 22.44576 ? 264 VAL   B CG1 1 
ATOM   4015 C  CG2 . VAL   B 1 264 ? -33.02953 -0.11500  -56.12654 1.000 17.08127 ? 264 VAL   B CG2 1 
ATOM   4016 N  N   . ILE   B 1 265 ? -29.28208 -0.23174  -53.51347 1.000 16.70288 ? 265 ILE   B N   1 
ATOM   4017 C  CA  . ILE   B 1 265 ? -28.01299 0.15236   -52.88121 1.000 14.10060 ? 265 ILE   B CA  1 
ATOM   4018 C  C   . ILE   B 1 265 ? -26.89361 -0.77842  -53.32687 1.000 17.43064 ? 265 ILE   B C   1 
ATOM   4019 O  O   . ILE   B 1 265 ? -25.83827 -0.32430  -53.78776 1.000 16.97419 ? 265 ILE   B O   1 
ATOM   4020 C  CB  . ILE   B 1 265 ? -28.13969 0.17501   -51.34356 1.000 10.92716 ? 265 ILE   B CB  1 
ATOM   4021 C  CG1 . ILE   B 1 265 ? -29.08833 1.28111   -50.88724 1.000 11.28659 ? 265 ILE   B CG1 1 
ATOM   4022 C  CG2 . ILE   B 1 265 ? -26.76392 0.35076   -50.67964 1.000 10.75313 ? 265 ILE   B CG2 1 
ATOM   4023 C  CD1 . ILE   B 1 265 ? -29.36118 1.29389   -49.37967 1.000 15.20093 ? 265 ILE   B CD1 1 
ATOM   4024 N  N   . ASP   B 1 266 ? -27.11691 -2.09915  -53.22039 1.000 14.56975 ? 266 ASP   B N   1 
ATOM   4025 C  CA  . ASP   B 1 266 ? -26.08885 -3.06049  -53.62790 1.000 18.05139 ? 266 ASP   B CA  1 
ATOM   4026 C  C   . ASP   B 1 266 ? -25.66377 -2.85717  -55.08260 1.000 15.77544 ? 266 ASP   B C   1 
ATOM   4027 O  O   . ASP   B 1 266 ? -24.48307 -2.99926  -55.41583 1.000 20.30873 ? 266 ASP   B O   1 
ATOM   4028 C  CB  . ASP   B 1 266 ? -26.58401 -4.49688  -53.42165 1.000 21.97988 ? 266 ASP   B CB  1 
ATOM   4029 C  CG  . ASP   B 1 266 ? -26.84139 -4.84320  -51.93928 1.000 23.90810 ? 266 ASP   B CG  1 
ATOM   4030 O  OD1 . ASP   B 1 266 ? -26.18142 -4.26380  -51.06633 1.000 20.83752 ? 266 ASP   B OD1 1 
ATOM   4031 O  OD2 . ASP   B 1 266 ? -27.70077 -5.71332  -51.65880 1.000 25.72901 ? 266 ASP   B OD2 1 
ATOM   4032 N  N   . ILE   B 1 267 ? -26.61003 -2.56587  -55.97061 1.000 14.82037 ? 267 ILE   B N   1 
ATOM   4033 C  CA  . ILE   B 1 267 ? -26.25564 -2.32466  -57.36724 1.000 16.58022 ? 267 ILE   B CA  1 
ATOM   4034 C  C   . ILE   B 1 267 ? -25.45577 -1.02696  -57.50069 1.000 14.57628 ? 267 ILE   B C   1 
ATOM   4035 O  O   . ILE   B 1 267 ? -24.33147 -1.02510  -58.00725 1.000 12.78845 ? 267 ILE   B O   1 
ATOM   4036 C  CB  . ILE   B 1 267 ? -27.51232 -2.29506  -58.25365 1.000 19.08649 ? 267 ILE   B CB  1 
ATOM   4037 C  CG1 . ILE   B 1 267 ? -28.20139 -3.67203  -58.26742 1.000 26.32727 ? 267 ILE   B CG1 1 
ATOM   4038 C  CG2 . ILE   B 1 267 ? -27.13608 -1.85217  -59.69057 1.000 16.31835 ? 267 ILE   B CG2 1 
ATOM   4039 C  CD1 . ILE   B 1 267 ? -29.65063 -3.63780  -58.84063 1.000 17.49621 ? 267 ILE   B CD1 1 
ATOM   4040 N  N   . VAL   B 1 268 ? -26.00892 0.09152   -57.01712 1.000 14.20504 ? 268 VAL   B N   1 
ATOM   4041 C  CA  . VAL   B 1 268 ? -25.37708 1.38425   -57.27888 1.000 9.50913  ? 268 VAL   B CA  1 
ATOM   4042 C  C   . VAL   B 1 268 ? -24.00992 1.46360   -56.62558 1.000 9.98526  ? 268 VAL   B C   1 
ATOM   4043 O  O   . VAL   B 1 268 ? -23.05192 1.92817   -57.24253 1.000 15.62370 ? 268 VAL   B O   1 
ATOM   4044 C  CB  . VAL   B 1 268 ? -26.28182 2.54187   -56.84565 1.000 11.17237 ? 268 VAL   B CB  1 
ATOM   4045 C  CG1 . VAL   B 1 268 ? -25.56749 3.87325   -57.12762 1.000 12.57511 ? 268 VAL   B CG1 1 
ATOM   4046 C  CG2 . VAL   B 1 268 ? -27.58844 2.47908   -57.65329 1.000 16.47213 ? 268 VAL   B CG2 1 
ATOM   4047 N  N   . LEU   B 1 269 ? -23.87791 0.97513   -55.39119 1.000 11.84280 ? 269 LEU   B N   1 
ATOM   4048 C  CA  . LEU   B 1 269 ? -22.55714 0.96986   -54.77150 1.000 14.87839 ? 269 LEU   B CA  1 
ATOM   4049 C  C   . LEU   B 1 269 ? -21.54611 0.22258   -55.62147 1.000 16.32995 ? 269 LEU   B C   1 
ATOM   4050 O  O   . LEU   B 1 269 ? -20.35592 0.56089   -55.61766 1.000 17.15193 ? 269 LEU   B O   1 
ATOM   4051 C  CB  . LEU   B 1 269 ? -22.61770 0.35761   -53.37240 1.000 16.56209 ? 269 LEU   B CB  1 
ATOM   4052 C  CG  . LEU   B 1 269 ? -23.22815 1.25534   -52.28906 1.000 11.13822 ? 269 LEU   B CG  1 
ATOM   4053 C  CD1 . LEU   B 1 269 ? -23.13629 0.62290   -50.89460 1.000 7.67388  ? 269 LEU   B CD1 1 
ATOM   4054 C  CD2 . LEU   B 1 269 ? -22.57782 2.61952   -52.32872 1.000 12.93446 ? 269 LEU   B CD2 1 
ATOM   4055 N  N   . ALA   B 1 270 ? -22.00413 -0.76091  -56.38475 1.000 15.49331 ? 270 ALA   B N   1 
ATOM   4056 C  CA  . ALA   B 1 270 ? -21.13075 -1.58341  -57.19549 1.000 11.60725 ? 270 ALA   B CA  1 
ATOM   4057 C  C   . ALA   B 1 270 ? -20.82899 -0.96649  -58.55154 1.000 12.31348 ? 270 ALA   B C   1 
ATOM   4058 O  O   . ALA   B 1 270 ? -20.09388 -1.57549  -59.33054 1.000 12.90751 ? 270 ALA   B O   1 
ATOM   4059 C  CB  . ALA   B 1 270 ? -21.75066 -2.97097  -57.38340 1.000 16.69622 ? 270 ALA   B CB  1 
ATOM   4060 N  N   . THR   B 1 271 ? -21.37236 0.21170   -58.86449 1.000 13.54011 ? 271 THR   B N   1 
ATOM   4061 C  CA  . THR   B 1 271 ? -20.93796 0.92419   -60.05628 1.000 12.97344 ? 271 THR   B CA  1 
ATOM   4062 C  C   . THR   B 1 271 ? -19.70137 1.77487   -59.80635 1.000 13.68307 ? 271 THR   B C   1 
ATOM   4063 O  O   . THR   B 1 271 ? -19.19640 2.40392   -60.74208 1.000 15.79300 ? 271 THR   B O   1 
ATOM   4064 C  CB  . THR   B 1 271 ? -22.05897 1.79806   -60.60914 1.000 13.06467 ? 271 THR   B CB  1 
ATOM   4065 O  OG1 . THR   B 1 271 ? -22.37055 2.83014   -59.67329 1.000 14.22186 ? 271 THR   B OG1 1 
ATOM   4066 C  CG2 . THR   B 1 271 ? -23.28349 0.95796   -60.88206 1.000 14.00281 ? 271 THR   B CG2 1 
ATOM   4067 N  N   . ASP   B 1 272 ? -19.22117 1.81646   -58.57182 1.000 13.72868 ? 272 ASP   B N   1 
ATOM   4068 C  CA  . ASP   B 1 272 ? -17.96310 2.47152   -58.23928 1.000 12.39375 ? 272 ASP   B CA  1 
ATOM   4069 C  C   . ASP   B 1 272 ? -16.82315 1.80378   -58.99227 1.000 16.54861 ? 272 ASP   B C   1 
ATOM   4070 O  O   . ASP   B 1 272 ? -16.54636 0.61837   -58.78391 1.000 18.95048 ? 272 ASP   B O   1 
ATOM   4071 C  CB  . ASP   B 1 272 ? -17.74651 2.39029   -56.72542 1.000 18.17283 ? 272 ASP   B CB  1 
ATOM   4072 C  CG  . ASP   B 1 272 ? -16.45725 3.06491   -56.24870 1.000 16.64840 ? 272 ASP   B CG  1 
ATOM   4073 O  OD1 . ASP   B 1 272 ? -15.58041 3.39280   -57.06994 1.000 16.83789 ? 272 ASP   B OD1 1 
ATOM   4074 O  OD2 . ASP   B 1 272 ? -16.31514 3.23451   -55.01868 1.000 17.89624 ? 272 ASP   B OD2 1 
ATOM   4075 N  N   . MET   B 1 273 ? -16.15025 2.56712   -59.86625 1.000 15.58565 ? 273 MET   B N   1 
ATOM   4076 C  CA  . MET   B 1 273 ? -15.12213 1.97579   -60.71819 1.000 19.40723 ? 273 MET   B CA  1 
ATOM   4077 C  C   . MET   B 1 273 ? -13.94975 1.38170   -59.93855 1.000 14.01112 ? 273 MET   B C   1 
ATOM   4078 O  O   . MET   B 1 273 ? -13.25724 0.50386   -60.46345 1.000 15.03846 ? 273 MET   B O   1 
ATOM   4079 C  CB  . MET   B 1 273 ? -14.60760 3.01281   -61.72336 1.000 28.45924 ? 273 MET   B CB  1 
ATOM   4080 C  CG  . MET   B 1 273 ? -15.52533 3.23081   -62.93269 1.000 26.98981 ? 273 MET   B CG  1 
ATOM   4081 S  SD  . MET   B 1 273 ? -15.76246 1.76650   -63.95280 1.000 30.97432 ? 273 MET   B SD  1 
ATOM   4082 C  CE  . MET   B 1 273 ? -14.11436 1.06248   -64.01538 1.000 23.37459 ? 273 MET   B CE  1 
ATOM   4083 N  N   . SER   B 1 274 ? -13.70081 1.83059   -58.70990 1.000 17.46737 ? 274 SER   B N   1 
ATOM   4084 C  CA  . SER   B 1 274 ? -12.65388 1.21267   -57.89684 1.000 16.13456 ? 274 SER   B CA  1 
ATOM   4085 C  C   . SER   B 1 274 ? -12.94670 -0.23621  -57.54310 1.000 19.18051 ? 274 SER   B C   1 
ATOM   4086 O  O   . SER   B 1 274 ? -12.02778 -0.93633  -57.11654 1.000 21.53911 ? 274 SER   B O   1 
ATOM   4087 C  CB  . SER   B 1 274 ? -12.43836 1.98544   -56.60180 1.000 18.93356 ? 274 SER   B CB  1 
ATOM   4088 O  OG  . SER   B 1 274 ? -13.65535 2.13119   -55.90495 1.000 22.64320 ? 274 SER   B OG  1 
ATOM   4089 N  N   . LYS   B 1 275 ? -14.18388 -0.70054  -57.70065 1.000 17.83750 ? 275 LYS   B N   1 
ATOM   4090 C  CA  . LYS   B 1 275 ? -14.55704 -2.07879  -57.40415 1.000 20.28524 ? 275 LYS   B CA  1 
ATOM   4091 C  C   . LYS   B 1 275 ? -14.59749 -2.94360  -58.65098 1.000 25.20968 ? 275 LYS   B C   1 
ATOM   4092 O  O   . LYS   B 1 275 ? -15.04844 -4.09516  -58.58986 1.000 21.48171 ? 275 LYS   B O   1 
ATOM   4093 C  CB  . LYS   B 1 275 ? -15.91459 -2.12057  -56.70605 1.000 13.94085 ? 275 LYS   B CB  1 
ATOM   4094 C  CG  . LYS   B 1 275 ? -15.89057 -1.45418  -55.34520 1.000 14.49796 ? 275 LYS   B CG  1 
ATOM   4095 C  CD  . LYS   B 1 275 ? -17.28838 -1.22852  -54.82670 1.000 19.86014 ? 275 LYS   B CD  1 
ATOM   4096 C  CE  . LYS   B 1 275 ? -17.27065 -0.39739  -53.54818 1.000 17.74583 ? 275 LYS   B CE  1 
ATOM   4097 N  NZ  . LYS   B 1 275 ? -18.60478 0.19303   -53.35862 1.000 17.24114 ? 275 LYS   B NZ  1 
ATOM   4098 N  N   . HIS   B 1 276 ? -14.12633 -2.41394  -59.77759 1.000 20.34447 ? 276 HIS   B N   1 
ATOM   4099 C  CA  . HIS   B 1 276 ? -14.30512 -3.10423  -61.04358 1.000 18.63872 ? 276 HIS   B CA  1 
ATOM   4100 C  C   . HIS   B 1 276 ? -13.59992 -4.45385  -61.05161 1.000 20.12004 ? 276 HIS   B C   1 
ATOM   4101 O  O   . HIS   B 1 276 ? -14.16773 -5.45152  -61.51248 1.000 18.84987 ? 276 HIS   B O   1 
ATOM   4102 C  CB  . HIS   B 1 276 ? -13.79878 -2.24399  -62.18899 1.000 13.60066 ? 276 HIS   B CB  1 
ATOM   4103 C  CG  . HIS   B 1 276 ? -13.59390 -3.03276  -63.43706 1.000 16.24046 ? 276 HIS   B CG  1 
ATOM   4104 N  ND1 . HIS   B 1 276 ? -14.63354 -3.38304  -64.26973 1.000 17.91448 ? 276 HIS   B ND1 1 
ATOM   4105 C  CD2 . HIS   B 1 276 ? -12.48751 -3.62355  -63.94253 1.000 15.40422 ? 276 HIS   B CD2 1 
ATOM   4106 C  CE1 . HIS   B 1 276 ? -14.16615 -4.10909  -65.26752 1.000 19.18495 ? 276 HIS   B CE1 1 
ATOM   4107 N  NE2 . HIS   B 1 276 ? -12.86542 -4.26853  -65.09313 1.000 19.93261 ? 276 HIS   B NE2 1 
ATOM   4108 N  N   . MET   B 1 277 ? -12.36525 -4.50375  -60.54479 1.000 19.26122 ? 277 MET   B N   1 
ATOM   4109 C  CA  . MET   B 1 277 ? -11.60683 -5.75279  -60.55087 1.000 25.07986 ? 277 MET   B CA  1 
ATOM   4110 C  C   . MET   B 1 277 ? -12.33122 -6.83583  -59.76347 1.000 29.46959 ? 277 MET   B C   1 
ATOM   4111 O  O   . MET   B 1 277 ? -12.67477 -7.89147  -60.30759 1.000 34.96760 ? 277 MET   B O   1 
ATOM   4112 C  CB  . MET   B 1 277 ? -10.20518 -5.53806  -59.98126 1.000 20.73167 ? 277 MET   B CB  1 
ATOM   4113 C  CG  . MET   B 1 277 ? -9.25645  -4.72091  -60.84577 1.000 34.39853 ? 277 MET   B CG  1 
ATOM   4114 S  SD  . MET   B 1 277 ? -9.29952  -5.12664  -62.60711 1.000 46.46567 ? 277 MET   B SD  1 
ATOM   4115 C  CE  . MET   B 1 277 ? -7.82053  -4.29048  -63.18489 1.000 44.50848 ? 277 MET   B CE  1 
ATOM   4116 N  N   . ASN   B 1 278 ? -12.56832 -6.58514  -58.46867 1.000 34.01103 ? 278 ASN   B N   1 
ATOM   4117 C  CA  . ASN   B 1 278 ? -13.24260 -7.56231  -57.61591 1.000 28.75615 ? 278 ASN   B CA  1 
ATOM   4118 C  C   . ASN   B 1 278 ? -14.57472 -8.00061  -58.20491 1.000 28.13080 ? 278 ASN   B C   1 
ATOM   4119 O  O   . ASN   B 1 278 ? -14.91241 -9.19177  -58.19435 1.000 29.96511 ? 278 ASN   B O   1 
ATOM   4120 C  CB  . ASN   B 1 278 ? -13.45326 -6.97480  -56.22295 1.000 27.65811 ? 278 ASN   B CB  1 
ATOM   4121 C  CG  . ASN   B 1 278 ? -12.15774 -6.66446  -55.52865 1.000 38.33364 ? 278 ASN   B CG  1 
ATOM   4122 O  OD1 . ASN   B 1 278 ? -11.07510 -7.01746  -56.01433 1.000 39.78239 ? 278 ASN   B OD1 1 
ATOM   4123 N  ND2 . ASN   B 1 278 ? -12.25066 -6.00678  -54.37833 1.000 41.43811 ? 278 ASN   B ND2 1 
ATOM   4124 N  N   . LEU   B 1 279 ? -15.34326 -7.04749  -58.72889 1.000 25.20252 ? 279 LEU   B N   1 
ATOM   4125 C  CA  . LEU   B 1 279 ? -16.61645 -7.37713  -59.35790 1.000 27.67427 ? 279 LEU   B CA  1 
ATOM   4126 C  C   . LEU   B 1 279 ? -16.43799 -8.31800  -60.55168 1.000 29.89894 ? 279 LEU   B C   1 
ATOM   4127 O  O   . LEU   B 1 279 ? -17.33781 -9.11133  -60.86095 1.000 32.65705 ? 279 LEU   B O   1 
ATOM   4128 C  CB  . LEU   B 1 279 ? -17.31253 -6.08069  -59.77032 1.000 24.47699 ? 279 LEU   B CB  1 
ATOM   4129 C  CG  . LEU   B 1 279 ? -18.78148 -6.08912  -60.18193 1.000 29.97833 ? 279 LEU   B CG  1 
ATOM   4130 C  CD1 . LEU   B 1 279 ? -19.65157 -6.66477  -59.05926 1.000 29.26564 ? 279 LEU   B CD1 1 
ATOM   4131 C  CD2 . LEU   B 1 279 ? -19.25364 -4.68913  -60.56140 1.000 21.00849 ? 279 LEU   B CD2 1 
ATOM   4132 N  N   . LEU   B 1 280 ? -15.29275 -8.25020  -61.23459 1.000 32.97491 ? 280 LEU   B N   1 
ATOM   4133 C  CA  . LEU   B 1 280 ? -15.08042 -9.09603  -62.40686 1.000 35.17828 ? 280 LEU   B CA  1 
ATOM   4134 C  C   . LEU   B 1 280 ? -14.56212 -10.47735 -62.01441 1.000 37.46142 ? 280 LEU   B C   1 
ATOM   4135 O  O   . LEU   B 1 280 ? -14.97688 -11.48661 -62.59709 1.000 35.35088 ? 280 LEU   B O   1 
ATOM   4136 C  CB  . LEU   B 1 280 ? -14.11609 -8.41989  -63.38714 1.000 32.42636 ? 280 LEU   B CB  1 
ATOM   4137 C  CG  . LEU   B 1 280 ? -13.60663 -9.30765  -64.53604 1.000 30.94568 ? 280 LEU   B CG  1 
ATOM   4138 C  CD1 . LEU   B 1 280 ? -14.73602 -9.64748  -65.49326 1.000 25.38130 ? 280 LEU   B CD1 1 
ATOM   4139 C  CD2 . LEU   B 1 280 ? -12.42341 -8.68108  -65.27431 1.000 29.64380 ? 280 LEU   B CD2 1 
ATOM   4140 N  N   . ALA   B 1 281 ? -13.64374 -10.53563 -61.04596 1.000 34.93889 ? 281 ALA   B N   1 
ATOM   4141 C  CA  . ALA   B 1 281 ? -13.27270 -11.81795 -60.45897 1.000 38.23429 ? 281 ALA   B CA  1 
ATOM   4142 C  C   . ALA   B 1 281 ? -14.49913 -12.56715 -59.95579 1.000 37.14079 ? 281 ALA   B C   1 
ATOM   4143 O  O   . ALA   B 1 281 ? -14.62202 -13.77849 -60.16229 1.000 45.96952 ? 281 ALA   B O   1 
ATOM   4144 C  CB  . ALA   B 1 281 ? -12.27356 -11.60692 -59.32379 1.000 40.51233 ? 281 ALA   B CB  1 
ATOM   4145 N  N   . ASP   B 1 282 ? -15.42758 -11.86379 -59.31015 1.000 30.33833 ? 282 ASP   B N   1 
ATOM   4146 C  CA  . ASP   B 1 282 ? -16.65616 -12.51854 -58.87573 1.000 39.73357 ? 282 ASP   B CA  1 
ATOM   4147 C  C   . ASP   B 1 282 ? -17.49370 -13.00294 -60.05349 1.000 39.81127 ? 282 ASP   B C   1 
ATOM   4148 O  O   . ASP   B 1 282 ? -18.26139 -13.96037 -59.91797 1.000 37.34924 ? 282 ASP   B O   1 
ATOM   4149 C  CB  . ASP   B 1 282 ? -17.47496 -11.57449 -57.99753 1.000 42.13712 ? 282 ASP   B CB  1 
ATOM   4150 C  CG  . ASP   B 1 282 ? -16.93977 -11.48846 -56.57862 1.000 40.43430 ? 282 ASP   B CG  1 
ATOM   4151 O  OD1 . ASP   B 1 282 ? -15.99491 -12.24009 -56.25467 1.000 40.48917 ? 282 ASP   B OD1 1 
ATOM   4152 O  OD2 . ASP   B 1 282 ? -17.46823 -10.67425 -55.79109 1.000 44.27404 ? 282 ASP   B OD2 1 
ATOM   4153 N  N   . LEU   B 1 283 ? -17.37714 -12.35734 -61.20772 1.000 38.98415 ? 283 LEU   B N   1 
ATOM   4154 C  CA  . LEU   B 1 283 ? -18.13826 -12.81215 -62.36130 1.000 40.14753 ? 283 LEU   B CA  1 
ATOM   4155 C  C   . LEU   B 1 283 ? -17.42056 -13.94376 -63.08820 1.000 43.58884 ? 283 LEU   B C   1 
ATOM   4156 O  O   . LEU   B 1 283 ? -18.07410 -14.80256 -63.69501 1.000 37.00835 ? 283 LEU   B O   1 
ATOM   4157 C  CB  . LEU   B 1 283 ? -18.39719 -11.63567 -63.30240 1.000 38.29204 ? 283 LEU   B CB  1 
ATOM   4158 C  CG  . LEU   B 1 283 ? -19.15253 -11.88574 -64.59782 1.000 32.84594 ? 283 LEU   B CG  1 
ATOM   4159 C  CD1 . LEU   B 1 283 ? -20.63491 -11.92309 -64.35396 1.000 30.53867 ? 283 LEU   B CD1 1 
ATOM   4160 C  CD2 . LEU   B 1 283 ? -18.81586 -10.78669 -65.58123 1.000 43.23255 ? 283 LEU   B CD2 1 
ATOM   4161 N  N   . LYS   B 1 284 ? -16.08552 -13.95985 -63.03573 1.000 37.87329 ? 284 LYS   B N   1 
ATOM   4162 C  CA  . LYS   B 1 284 ? -15.33652 -15.07183 -63.60838 1.000 40.29733 ? 284 LYS   B CA  1 
ATOM   4163 C  C   . LYS   B 1 284 ? -15.57617 -16.34346 -62.81262 1.000 45.57941 ? 284 LYS   B C   1 
ATOM   4164 O  O   . LYS   B 1 284 ? -15.89263 -17.39096 -63.38550 1.000 44.49375 ? 284 LYS   B O   1 
ATOM   4165 C  CB  . LYS   B 1 284 ? -13.84695 -14.74032 -63.66146 1.000 29.55939 ? 284 LYS   B CB  1 
ATOM   4166 C  CG  . LYS   B 1 284 ? -13.51091 -13.75418 -64.76598 1.000 36.01267 ? 284 LYS   B CG  1 
ATOM   4167 C  CD  . LYS   B 1 284 ? -12.04363 -13.39401 -64.77869 1.000 29.81113 ? 284 LYS   B CD  1 
ATOM   4168 C  CE  . LYS   B 1 284 ? -11.73408 -12.44820 -65.92931 1.000 25.25228 ? 284 LYS   B CE  1 
ATOM   4169 N  NZ  . LYS   B 1 284 ? -10.29754 -12.08030 -65.94273 1.000 27.65126 ? 284 LYS   B NZ  1 
ATOM   4170 N  N   . THR   B 1 285 ? -15.43146 -16.26515 -61.48601 1.000 42.25286 ? 285 THR   B N   1 
ATOM   4171 C  CA  . THR   B 1 285 ? -15.76987 -17.39175 -60.62685 1.000 43.17955 ? 285 THR   B CA  1 
ATOM   4172 C  C   . THR   B 1 285 ? -17.16575 -17.91513 -60.93363 1.000 38.46163 ? 285 THR   B C   1 
ATOM   4173 O  O   . THR   B 1 285 ? -17.36066 -19.11694 -61.13529 1.000 47.87999 ? 285 THR   B O   1 
ATOM   4174 C  CB  . THR   B 1 285 ? -15.64604 -16.98188 -59.16467 1.000 35.92000 ? 285 THR   B CB  1 
ATOM   4175 O  OG1 . THR   B 1 285 ? -14.27369 -16.66592 -58.87840 1.000 29.83464 ? 285 THR   B OG1 1 
ATOM   4176 C  CG2 . THR   B 1 285 ? -16.10066 -18.11542 -58.27238 1.000 41.64287 ? 285 THR   B CG2 1 
ATOM   4177 N  N   . MET   B 1 286 ? -18.14146 -17.01512 -61.02409 1.000 39.19585 ? 286 MET   B N   1 
ATOM   4178 C  CA  . MET   B 1 286 ? -19.48441 -17.41395 -61.42890 1.000 40.41895 ? 286 MET   B CA  1 
ATOM   4179 C  C   . MET   B 1 286 ? -19.51760 -18.07731 -62.80585 1.000 48.22172 ? 286 MET   B C   1 
ATOM   4180 O  O   . MET   B 1 286 ? -20.45310 -18.83176 -63.09621 1.000 47.85988 ? 286 MET   B O   1 
ATOM   4181 C  CB  . MET   B 1 286 ? -20.41089 -16.20122 -61.40568 1.000 38.02505 ? 286 MET   B CB  1 
ATOM   4182 C  CG  . MET   B 1 286 ? -21.84085 -16.50856 -61.78890 1.000 32.05945 ? 286 MET   B CG  1 
ATOM   4183 S  SD  . MET   B 1 286 ? -22.98781 -15.43586 -60.92436 1.000 59.71659 ? 286 MET   B SD  1 
ATOM   4184 C  CE  . MET   B 1 286 ? -22.20299 -15.39916 -59.32139 1.000 47.09098 ? 286 MET   B CE  1 
ATOM   4185 N  N   . VAL   B 1 287 ? -18.53059 -17.82305 -63.66043 1.000 45.53110 ? 287 VAL   B N   1 
ATOM   4186 C  CA  . VAL   B 1 287 ? -18.47767 -18.50416 -64.95027 1.000 49.54107 ? 287 VAL   B CA  1 
ATOM   4187 C  C   . VAL   B 1 287 ? -17.66233 -19.79196 -64.86009 1.000 53.11841 ? 287 VAL   B C   1 
ATOM   4188 O  O   . VAL   B 1 287 ? -17.97952 -20.78078 -65.52739 1.000 58.37745 ? 287 VAL   B O   1 
ATOM   4189 C  CB  . VAL   B 1 287 ? -17.93744 -17.54639 -66.03640 1.000 45.57631 ? 287 VAL   B CB  1 
ATOM   4190 C  CG1 . VAL   B 1 287 ? -17.25143 -18.31833 -67.15691 1.000 41.30843 ? 287 VAL   B CG1 1 
ATOM   4191 C  CG2 . VAL   B 1 287 ? -19.08353 -16.67964 -66.59885 1.000 44.19777 ? 287 VAL   B CG2 1 
ATOM   4192 N  N   . GLU   B 1 288 ? -16.62226 -19.80846 -64.02326 1.000 49.18177 ? 288 GLU   B N   1 
ATOM   4193 C  CA  . GLU   B 1 288 ? -15.84200 -21.02369 -63.81376 1.000 53.52826 ? 288 GLU   B CA  1 
ATOM   4194 C  C   . GLU   B 1 288 ? -16.74470 -22.18279 -63.40781 1.000 62.25682 ? 288 GLU   B C   1 
ATOM   4195 O  O   . GLU   B 1 288 ? -16.78414 -23.22583 -64.06967 1.000 67.67454 ? 288 GLU   B O   1 
ATOM   4196 C  CB  . GLU   B 1 288 ? -14.76254 -20.78042 -62.75466 1.000 53.86118 ? 288 GLU   B CB  1 
ATOM   4197 C  CG  . GLU   B 1 288 ? -13.54851 -20.00539 -63.25579 1.000 63.28064 ? 288 GLU   B CG  1 
ATOM   4198 C  CD  . GLU   B 1 288 ? -12.24901 -20.48735 -62.62958 1.000 73.09026 ? 288 GLU   B CD  1 
ATOM   4199 O  OE1 . GLU   B 1 288 ? -11.59753 -19.70034 -61.90876 1.000 71.73080 ? 288 GLU   B OE1 1 
ATOM   4200 O  OE2 . GLU   B 1 288 ? -11.88128 -21.65901 -62.85806 1.000 78.07562 ? 288 GLU   B OE2 1 
ATOM   4201 N  N   . THR   B 1 289 ? -17.48994 -22.00651 -62.32450 1.000 61.02172 ? 289 THR   B N   1 
ATOM   4202 C  CA  . THR   B 1 289 ? -18.49278 -22.98089 -61.89837 1.000 63.22901 ? 289 THR   B CA  1 
ATOM   4203 C  C   . THR   B 1 289 ? -19.89158 -22.51381 -62.27751 1.000 56.35376 ? 289 THR   B C   1 
ATOM   4204 O  O   . THR   B 1 289 ? -20.83019 -22.49190 -61.48272 1.000 54.62797 ? 289 THR   B O   1 
ATOM   4205 C  CB  . THR   B 1 289 ? -18.36361 -23.24684 -60.40604 1.000 61.85647 ? 289 THR   B CB  1 
ATOM   4206 O  OG1 . THR   B 1 289 ? -18.28250 -22.00161 -59.69941 1.000 57.60367 ? 289 THR   B OG1 1 
ATOM   4207 C  CG2 . THR   B 1 289 ? -17.09561 -24.05730 -60.14128 1.000 60.95652 ? 289 THR   B CG2 1 
ATOM   4208 N  N   . LYS   B 1 290 ? -19.99475 -22.10617 -63.54004 1.000 56.04172 ? 290 LYS   B N   1 
ATOM   4209 C  CA  . LYS   B 1 290 ? -21.27904 -21.86530 -64.17769 1.000 56.19506 ? 290 LYS   B CA  1 
ATOM   4210 C  C   . LYS   B 1 290 ? -22.10024 -23.14385 -64.17523 1.000 58.94931 ? 290 LYS   B C   1 
ATOM   4211 O  O   . LYS   B 1 290 ? -21.57848 -24.23050 -64.44276 1.000 57.15783 ? 290 LYS   B O   1 
ATOM   4212 C  CB  . LYS   B 1 290 ? -21.04879 -21.38762 -65.61308 1.000 58.70077 ? 290 LYS   B CB  1 
ATOM   4213 C  CG  . LYS   B 1 290 ? -22.18310 -20.61912 -66.26570 1.000 62.99928 ? 290 LYS   B CG  1 
ATOM   4214 C  CD  . LYS   B 1 290 ? -22.07061 -20.73803 -67.78802 1.000 59.87693 ? 290 LYS   B CD  1 
ATOM   4215 C  CE  . LYS   B 1 290 ? -23.42419 -20.55261 -68.47225 1.000 56.05888 ? 290 LYS   B CE  1 
ATOM   4216 N  NZ  . LYS   B 1 290 ? -23.34779 -20.64731 -69.95758 1.000 54.80728 ? 290 LYS   B NZ  1 
ATOM   4217 N  N   . LYS   B 1 291 ? -23.39096 -23.01602 -63.86446 1.000 63.98866 ? 291 LYS   B N   1 
ATOM   4218 C  CA  . LYS   B 1 291 ? -24.30316 -24.15402 -63.88129 1.000 62.30857 ? 291 LYS   B CA  1 
ATOM   4219 C  C   . LYS   B 1 291 ? -25.52290 -23.81754 -64.72638 1.000 57.72528 ? 291 LYS   B C   1 
ATOM   4220 O  O   . LYS   B 1 291 ? -26.11594 -22.74212 -64.58070 1.000 53.36052 ? 291 LYS   B O   1 
ATOM   4221 C  CB  . LYS   B 1 291 ? -24.70423 -24.58450 -62.46245 1.000 56.12992 ? 291 LYS   B CB  1 
ATOM   4222 C  CG  . LYS   B 1 291 ? -23.52657 -25.13515 -61.64510 1.000 56.93983 ? 291 LYS   B CG  1 
ATOM   4223 C  CD  . LYS   B 1 291 ? -22.90730 -26.38045 -62.29951 1.000 59.60071 ? 291 LYS   B CD  1 
ATOM   4224 C  CE  . LYS   B 1 291 ? -21.54589 -26.72886 -61.69663 1.000 62.23951 ? 291 LYS   B CE  1 
ATOM   4225 N  NZ  . LYS   B 1 291 ? -20.43512 -26.67360 -62.69660 1.000 60.87578 ? 291 LYS   B NZ  1 
ATOM   4226 N  N   . VAL   B 1 292 ? -25.89112 -24.76353 -65.59457 1.000 57.11702 ? 292 VAL   B N   1 
ATOM   4227 C  CA  . VAL   B 1 292 ? -26.71883 -24.53478 -66.77217 1.000 64.61565 ? 292 VAL   B CA  1 
ATOM   4228 C  C   . VAL   B 1 292 ? -27.72594 -25.66842 -66.89804 1.000 64.58587 ? 292 VAL   B C   1 
ATOM   4229 O  O   . VAL   B 1 292 ? -27.40796 -26.82819 -66.61848 1.000 66.84839 ? 292 VAL   B O   1 
ATOM   4230 C  CB  . VAL   B 1 292 ? -25.85124 -24.49105 -68.05714 1.000 64.35063 ? 292 VAL   B CB  1 
ATOM   4231 C  CG1 . VAL   B 1 292 ? -26.60972 -23.90094 -69.21248 1.000 65.41029 ? 292 VAL   B CG1 1 
ATOM   4232 C  CG2 . VAL   B 1 292 ? -24.53024 -23.76793 -67.82812 1.000 63.16895 ? 292 VAL   B CG2 1 
ATOM   4233 N  N   . THR   B 1 293 ? -28.93465 -25.34612 -67.36151 1.000 61.72188 ? 293 THR   B N   1 
ATOM   4234 C  CA  . THR   B 1 293 ? -29.80271 -26.40830 -67.85018 1.000 63.49249 ? 293 THR   B CA  1 
ATOM   4235 C  C   . THR   B 1 293 ? -29.18044 -27.01857 -69.10602 1.000 72.22904 ? 293 THR   B C   1 
ATOM   4236 O  O   . THR   B 1 293 ? -28.48140 -26.33930 -69.86536 1.000 69.92852 ? 293 THR   B O   1 
ATOM   4237 C  CB  . THR   B 1 293 ? -31.22273 -25.89015 -68.13627 1.000 66.60959 ? 293 THR   B CB  1 
ATOM   4238 O  OG1 . THR   B 1 293 ? -31.24795 -25.10665 -69.33704 1.000 60.11370 ? 293 THR   B OG1 1 
ATOM   4239 C  CG2 . THR   B 1 293 ? -31.72696 -25.04239 -66.97892 1.000 59.23928 ? 293 THR   B CG2 1 
ATOM   4240 N  N   . SER   B 1 294 ? -29.39180 -28.32864 -69.29316 1.000 74.81097 ? 294 SER   B N   1 
ATOM   4241 C  CA  . SER   B 1 294 ? -28.89090 -28.99866 -70.49220 1.000 70.62247 ? 294 SER   B CA  1 
ATOM   4242 C  C   . SER   B 1 294 ? -29.16008 -28.13441 -71.71264 1.000 70.03142 ? 294 SER   B C   1 
ATOM   4243 O  O   . SER   B 1 294 ? -28.26723 -27.89048 -72.53123 1.000 71.37463 ? 294 SER   B O   1 
ATOM   4244 C  CB  . SER   B 1 294 ? -29.54233 -30.37632 -70.65119 1.000 73.00631 ? 294 SER   B CB  1 
ATOM   4245 O  OG  . SER   B 1 294 ? -29.41463 -31.15681 -69.47046 1.000 73.39441 ? 294 SER   B OG  1 
ATOM   4246 N  N   . SER   B 1 295 ? -30.38758 -27.61597 -71.80288 1.000 71.46057 ? 295 SER   B N   1 
ATOM   4247 C  CA  . SER   B 1 295 ? -30.77825 -26.61121 -72.78541 1.000 71.14232 ? 295 SER   B CA  1 
ATOM   4248 C  C   . SER   B 1 295 ? -30.02149 -25.29762 -72.59243 1.000 69.37197 ? 295 SER   B C   1 
ATOM   4249 O  O   . SER   B 1 295 ? -28.94822 -25.10934 -73.17887 1.000 57.08315 ? 295 SER   B O   1 
ATOM   4250 C  CB  . SER   B 1 295 ? -32.29212 -26.37600 -72.71737 1.000 64.78936 ? 295 SER   B CB  1 
ATOM   4251 O  OG  . SER   B 1 295 ? -32.76463 -26.43723 -71.38100 1.000 65.36035 ? 295 SER   B OG  1 
ATOM   4252 N  N   . GLY   B 1 296 ? -30.55469 -24.38756 -71.76888 1.000 68.32234 ? 296 GLY   B N   1 
ATOM   4253 C  CA  . GLY   B 1 296 ? -30.00896 -23.04064 -71.73414 1.000 68.90516 ? 296 GLY   B CA  1 
ATOM   4254 C  C   . GLY   B 1 296 ? -29.86885 -22.28631 -70.41785 1.000 72.31763 ? 296 GLY   B C   1 
ATOM   4255 O  O   . GLY   B 1 296 ? -28.74796 -22.07693 -69.94543 1.000 64.54241 ? 296 GLY   B O   1 
ATOM   4256 N  N   . VAL   B 1 297 ? -30.98860 -21.85418 -69.82979 1.000 66.46360 ? 297 VAL   B N   1 
ATOM   4257 C  CA  . VAL   B 1 297 ? -31.02386 -20.77698 -68.83577 1.000 61.87192 ? 297 VAL   B CA  1 
ATOM   4258 C  C   . VAL   B 1 297 ? -30.04581 -20.98088 -67.67568 1.000 68.01683 ? 297 VAL   B C   1 
ATOM   4259 O  O   . VAL   B 1 297 ? -29.70189 -22.11413 -67.31259 1.000 66.99275 ? 297 VAL   B O   1 
ATOM   4260 C  CB  . VAL   B 1 297 ? -32.46860 -20.58620 -68.33128 1.000 62.61874 ? 297 VAL   B CB  1 
ATOM   4261 C  CG1 . VAL   B 1 297 ? -32.54708 -19.59285 -67.18421 1.000 61.49648 ? 297 VAL   B CG1 1 
ATOM   4262 C  CG2 . VAL   B 1 297 ? -33.34867 -20.11046 -69.47468 1.000 66.33822 ? 297 VAL   B CG2 1 
ATOM   4263 N  N   . LEU   B 1 298 ? -29.56888 -19.86434 -67.11759 1.000 67.72319 ? 298 LEU   B N   1 
ATOM   4264 C  CA  . LEU   B 1 298 ? -28.59910 -19.85675 -66.02946 1.000 60.08689 ? 298 LEU   B CA  1 
ATOM   4265 C  C   . LEU   B 1 298 ? -29.28277 -20.06267 -64.68033 1.000 50.30814 ? 298 LEU   B C   1 
ATOM   4266 O  O   . LEU   B 1 298 ? -30.31100 -19.44211 -64.38310 1.000 41.16171 ? 298 LEU   B O   1 
ATOM   4267 C  CB  . LEU   B 1 298 ? -27.84495 -18.52664 -66.03049 1.000 57.48807 ? 298 LEU   B CB  1 
ATOM   4268 C  CG  . LEU   B 1 298 ? -26.63704 -18.34690 -65.11568 1.000 52.80921 ? 298 LEU   B CG  1 
ATOM   4269 C  CD1 . LEU   B 1 298 ? -25.48914 -19.22924 -65.56685 1.000 53.66567 ? 298 LEU   B CD1 1 
ATOM   4270 C  CD2 . LEU   B 1 298 ? -26.22813 -16.88002 -65.09433 1.000 54.08192 ? 298 LEU   B CD2 1 
ATOM   4271 N  N   . LEU   B 1 299 ? -28.68453 -20.91633 -63.84887 1.000 50.69294 ? 299 LEU   B N   1 
ATOM   4272 C  CA  . LEU   B 1 299 ? -29.25350 -21.29708 -62.55341 1.000 49.97615 ? 299 LEU   B CA  1 
ATOM   4273 C  C   . LEU   B 1 299 ? -28.48744 -20.61971 -61.41561 1.000 44.47994 ? 299 LEU   B C   1 
ATOM   4274 O  O   . LEU   B 1 299 ? -27.38151 -21.04045 -61.05629 1.000 42.72162 ? 299 LEU   B O   1 
ATOM   4275 C  CB  . LEU   B 1 299 ? -29.24983 -22.81602 -62.38509 1.000 44.07948 ? 299 LEU   B CB  1 
ATOM   4276 C  CG  . LEU   B 1 299 ? -30.39994 -23.63179 -62.99814 1.000 42.62896 ? 299 LEU   B CG  1 
ATOM   4277 C  CD1 . LEU   B 1 299 ? -31.45213 -22.75830 -63.70239 1.000 37.86972 ? 299 LEU   B CD1 1 
ATOM   4278 C  CD2 . LEU   B 1 299 ? -29.87252 -24.73315 -63.90931 1.000 36.18018 ? 299 LEU   B CD2 1 
ATOM   4279 N  N   . LEU   B 1 300 ? -29.10365 -19.59006 -60.83757 1.000 43.35109 ? 300 LEU   B N   1 
ATOM   4280 C  CA  . LEU   B 1 300 ? -28.62848 -18.91765 -59.63637 1.000 42.87896 ? 300 LEU   B CA  1 
ATOM   4281 C  C   . LEU   B 1 300 ? -29.56306 -19.25210 -58.48389 1.000 31.34135 ? 300 LEU   B C   1 
ATOM   4282 O  O   . LEU   B 1 300 ? -30.78678 -19.20391 -58.64072 1.000 29.25147 ? 300 LEU   B O   1 
ATOM   4283 C  CB  . LEU   B 1 300 ? -28.60836 -17.40267 -59.83151 1.000 45.57923 ? 300 LEU   B CB  1 
ATOM   4284 C  CG  . LEU   B 1 300 ? -28.00934 -16.90726 -61.14075 1.000 42.29926 ? 300 LEU   B CG  1 
ATOM   4285 C  CD1 . LEU   B 1 300 ? -28.15048 -15.39667 -61.20593 1.000 51.14645 ? 300 LEU   B CD1 1 
ATOM   4286 C  CD2 . LEU   B 1 300 ? -26.54853 -17.32995 -61.25536 1.000 41.08842 ? 300 LEU   B CD2 1 
ATOM   4287 N  N   . ASP   B 1 301 ? -28.99913 -19.57108 -57.32187 1.000 29.21015 ? 301 ASP   B N   1 
ATOM   4288 C  CA  . ASP   B 1 301 ? -29.82649 -19.95996 -56.18789 1.000 37.53129 ? 301 ASP   B CA  1 
ATOM   4289 C  C   . ASP   B 1 301 ? -29.85302 -18.91073 -55.08326 1.000 39.67269 ? 301 ASP   B C   1 
ATOM   4290 O  O   . ASP   B 1 301 ? -30.92056 -18.38434 -54.75466 1.000 43.56810 ? 301 ASP   B O   1 
ATOM   4291 C  CB  . ASP   B 1 301 ? -29.36777 -21.30939 -55.62308 1.000 38.01831 ? 301 ASP   B CB  1 
ATOM   4292 C  CG  . ASP   B 1 301 ? -30.43677 -21.96017 -54.77167 1.000 24.18308 ? 301 ASP   B CG  1 
ATOM   4293 O  OD1 . ASP   B 1 301 ? -31.58571 -22.06872 -55.25322 1.000 21.62075 ? 301 ASP   B OD1 1 
ATOM   4294 O  OD2 . ASP   B 1 301 ? -30.13040 -22.32925 -53.61930 1.000 29.43534 ? 301 ASP   B OD2 1 
ATOM   4295 N  N   . ASN   B 1 302 ? -28.71307 -18.60764 -54.47389 1.000 44.65333 ? 302 ASN   B N   1 
ATOM   4296 C  CA  . ASN   B 1 302 ? -28.71017 -17.64500 -53.38261 1.000 48.50539 ? 302 ASN   B CA  1 
ATOM   4297 C  C   . ASN   B 1 302 ? -28.65120 -16.21945 -53.91479 1.000 44.95948 ? 302 ASN   B C   1 
ATOM   4298 O  O   . ASN   B 1 302 ? -28.16211 -15.96058 -55.01846 1.000 41.58273 ? 302 ASN   B O   1 
ATOM   4299 C  CB  . ASN   B 1 302 ? -27.53535 -17.89047 -52.43924 1.000 42.74243 ? 302 ASN   B CB  1 
ATOM   4300 C  CG  . ASN   B 1 302 ? -26.23345 -18.10598 -53.17677 1.000 50.06409 ? 302 ASN   B CG  1 
ATOM   4301 O  OD1 . ASN   B 1 302 ? -25.67561 -17.17500 -53.75165 1.000 55.54805 ? 302 ASN   B OD1 1 
ATOM   4302 N  ND2 . ASN   B 1 302 ? -25.73407 -19.33558 -53.15493 1.000 50.64587 ? 302 ASN   B ND2 1 
ATOM   4303 N  N   . TYR   B 1 303 ? -29.17420 -15.29515 -53.10707 1.000 46.02447 ? 303 TYR   B N   1 
ATOM   4304 C  CA  . TYR   B 1 303 ? -29.08543 -13.87233 -53.41253 1.000 46.87736 ? 303 TYR   B CA  1 
ATOM   4305 C  C   . TYR   B 1 303 ? -27.67043 -13.46377 -53.80437 1.000 38.51641 ? 303 TYR   B C   1 
ATOM   4306 O  O   . TYR   B 1 303 ? -27.47546 -12.72167 -54.77177 1.000 42.12109 ? 303 TYR   B O   1 
ATOM   4307 C  CB  . TYR   B 1 303 ? -29.56009 -13.07486 -52.19677 1.000 49.24928 ? 303 TYR   B CB  1 
ATOM   4308 C  CG  . TYR   B 1 303 ? -29.50605 -11.57168 -52.34453 1.000 44.11767 ? 303 TYR   B CG  1 
ATOM   4309 C  CD1 . TYR   B 1 303 ? -30.47361 -10.89013 -53.07540 1.000 36.12399 ? 303 TYR   B CD1 1 
ATOM   4310 C  CD2 . TYR   B 1 303 ? -28.50298 -10.83594 -51.72855 1.000 32.61433 ? 303 TYR   B CD2 1 
ATOM   4311 C  CE1 . TYR   B 1 303 ? -30.43373 -9.52157  -53.20225 1.000 34.85052 ? 303 TYR   B CE1 1 
ATOM   4312 C  CE2 . TYR   B 1 303 ? -28.45094 -9.47017  -51.84356 1.000 34.38962 ? 303 TYR   B CE2 1 
ATOM   4313 C  CZ  . TYR   B 1 303 ? -29.41858 -8.81181  -52.58293 1.000 43.33897 ? 303 TYR   B CZ  1 
ATOM   4314 O  OH  . TYR   B 1 303 ? -29.36758 -7.43703  -52.69854 1.000 44.73657 ? 303 TYR   B OH  1 
ATOM   4315 N  N   . SER   B 1 304 ? -26.66979 -13.95381 -53.07443 1.000 33.43010 ? 304 SER   B N   1 
ATOM   4316 C  CA  . SER   B 1 304 ? -25.30609 -13.48145 -53.28538 1.000 43.96075 ? 304 SER   B CA  1 
ATOM   4317 C  C   . SER   B 1 304 ? -24.84948 -13.67407 -54.72489 1.000 51.50911 ? 304 SER   B C   1 
ATOM   4318 O  O   . SER   B 1 304 ? -24.11345 -12.83584 -55.26160 1.000 47.44117 ? 304 SER   B O   1 
ATOM   4319 C  CB  . SER   B 1 304 ? -24.34863 -14.19064 -52.33423 1.000 41.46515 ? 304 SER   B CB  1 
ATOM   4320 O  OG  . SER   B 1 304 ? -23.03089 -13.70693 -52.51517 1.000 52.77300 ? 304 SER   B OG  1 
ATOM   4321 N  N   . ASP   B 1 305 ? -25.27465 -14.76022 -55.36744 1.000 49.50327 ? 305 ASP   B N   1 
ATOM   4322 C  CA  . ASP   B 1 305 ? -24.92659 -14.95527 -56.76707 1.000 46.08787 ? 305 ASP   B CA  1 
ATOM   4323 C  C   . ASP   B 1 305 ? -25.77289 -14.07328 -57.67739 1.000 45.80433 ? 305 ASP   B C   1 
ATOM   4324 O  O   . ASP   B 1 305 ? -25.27287 -13.55797 -58.68149 1.000 45.93206 ? 305 ASP   B O   1 
ATOM   4325 C  CB  . ASP   B 1 305 ? -25.07608 -16.43333 -57.14184 1.000 49.42417 ? 305 ASP   B CB  1 
ATOM   4326 C  CG  . ASP   B 1 305 ? -23.94424 -17.29824 -56.58635 1.000 57.84682 ? 305 ASP   B CG  1 
ATOM   4327 O  OD1 . ASP   B 1 305 ? -22.78128 -16.83044 -56.56080 1.000 51.04351 ? 305 ASP   B OD1 1 
ATOM   4328 O  OD2 . ASP   B 1 305 ? -24.21666 -18.44842 -56.17114 1.000 63.09359 ? 305 ASP   B OD2 1 
ATOM   4329 N  N   . ARG   B 1 306 ? -27.04139 -13.86249 -57.33052 1.000 40.25936 ? 306 ARG   B N   1 
ATOM   4330 C  CA  . ARG   B 1 306 ? -27.95379 -13.17257 -58.23496 1.000 43.29844 ? 306 ARG   B CA  1 
ATOM   4331 C  C   . ARG   B 1 306 ? -27.76456 -11.65903 -58.22593 1.000 48.54377 ? 306 ARG   B C   1 
ATOM   4332 O  O   . ARG   B 1 306 ? -27.83170 -11.01354 -59.27955 1.000 49.20229 ? 306 ARG   B O   1 
ATOM   4333 C  CB  . ARG   B 1 306 ? -29.38317 -13.52491 -57.86259 1.000 43.92743 ? 306 ARG   B CB  1 
ATOM   4334 C  CG  . ARG   B 1 306 ? -30.41503 -12.62345 -58.45853 1.000 50.49413 ? 306 ARG   B CG  1 
ATOM   4335 C  CD  . ARG   B 1 306 ? -31.73841 -13.02576 -57.94839 1.000 60.58496 ? 306 ARG   B CD  1 
ATOM   4336 N  NE  . ARG   B 1 306 ? -31.71086 -14.42264 -57.52717 1.000 53.25787 ? 306 ARG   B NE  1 
ATOM   4337 C  CZ  . ARG   B 1 306 ? -32.34722 -14.88080 -56.45931 1.000 58.96180 ? 306 ARG   B CZ  1 
ATOM   4338 N  NH1 . ARG   B 1 306 ? -33.05976 -14.04343 -55.69899 1.000 65.83982 ? 306 ARG   B NH1 1 
ATOM   4339 N  NH2 . ARG   B 1 306 ? -32.24655 -16.16554 -56.14875 1.000 53.23217 ? 306 ARG   B NH2 1 
ATOM   4340 N  N   . ILE   B 1 307 ? -27.59413 -11.06244 -57.04981 1.000 44.27996 ? 307 ILE   B N   1 
ATOM   4341 C  CA  . ILE   B 1 307 ? -27.33675 -9.63002  -57.01278 1.000 40.40439 ? 307 ILE   B CA  1 
ATOM   4342 C  C   . ILE   B 1 307 ? -26.02390 -9.32981  -57.71828 1.000 38.40300 ? 307 ILE   B C   1 
ATOM   4343 O  O   . ILE   B 1 307 ? -25.87744 -8.30352  -58.38891 1.000 35.77186 ? 307 ILE   B O   1 
ATOM   4344 C  CB  . ILE   B 1 307 ? -27.33686 -9.12269  -55.55880 1.000 28.12791 ? 307 ILE   B CB  1 
ATOM   4345 C  CG1 . ILE   B 1 307 ? -27.33069 -7.59440  -55.53478 1.000 24.09910 ? 307 ILE   B CG1 1 
ATOM   4346 C  CG2 . ILE   B 1 307 ? -26.16210 -9.67683  -54.79051 1.000 25.74180 ? 307 ILE   B CG2 1 
ATOM   4347 C  CD1 . ILE   B 1 307 ? -28.65593 -6.97730  -55.93085 1.000 20.13090 ? 307 ILE   B CD1 1 
ATOM   4348 N  N   . GLN   B 1 308 ? -25.06582 -10.24697 -57.59475 1.000 36.33697 ? 308 GLN   B N   1 
ATOM   4349 C  CA  . GLN   B 1 308 ? -23.77539 -10.13145 -58.24771 1.000 37.09033 ? 308 GLN   B CA  1 
ATOM   4350 C  C   . GLN   B 1 308 ? -23.90945 -10.10857 -59.76164 1.000 42.30009 ? 308 GLN   B C   1 
ATOM   4351 O  O   . GLN   B 1 308 ? -23.06826 -9.52090  -60.45136 1.000 40.28623 ? 308 GLN   B O   1 
ATOM   4352 C  CB  . GLN   B 1 308 ? -22.90732 -11.29565 -57.79161 1.000 45.06694 ? 308 GLN   B CB  1 
ATOM   4353 C  CG  . GLN   B 1 308 ? -21.53164 -11.35430 -58.35930 1.000 46.23061 ? 308 GLN   B CG  1 
ATOM   4354 C  CD  . GLN   B 1 308 ? -20.70846 -12.40110 -57.65350 1.000 51.48535 ? 308 GLN   B CD  1 
ATOM   4355 O  OE1 . GLN   B 1 308 ? -20.65045 -12.43421 -56.41866 1.000 57.41416 ? 308 GLN   B OE1 1 
ATOM   4356 N  NE2 . GLN   B 1 308 ? -20.07100 -13.27185 -58.42593 1.000 53.90535 ? 308 GLN   B NE2 1 
ATOM   4357 N  N   . VAL   B 1 309 ? -24.94392 -10.75179 -60.29850 1.000 39.55736 ? 309 VAL   B N   1 
ATOM   4358 C  CA  . VAL   B 1 309 ? -25.18456 -10.68982 -61.73387 1.000 38.21401 ? 309 VAL   B CA  1 
ATOM   4359 C  C   . VAL   B 1 309 ? -25.79603 -9.34933  -62.10497 1.000 34.44047 ? 309 VAL   B C   1 
ATOM   4360 O  O   . VAL   B 1 309 ? -25.46852 -8.76417  -63.14308 1.000 35.41900 ? 309 VAL   B O   1 
ATOM   4361 C  CB  . VAL   B 1 309 ? -26.07529 -11.87139 -62.17145 1.000 38.11986 ? 309 VAL   B CB  1 
ATOM   4362 C  CG1 . VAL   B 1 309 ? -26.79801 -11.56184 -63.46258 1.000 36.36672 ? 309 VAL   B CG1 1 
ATOM   4363 C  CG2 . VAL   B 1 309 ? -25.24549 -13.13399 -62.33158 1.000 39.07800 ? 309 VAL   B CG2 1 
ATOM   4364 N  N   . LEU   B 1 310 ? -26.69889 -8.84724  -61.26764 1.000 35.57757 ? 310 LEU   B N   1 
ATOM   4365 C  CA  . LEU   B 1 310 ? -27.27149 -7.53119  -61.50558 1.000 35.40097 ? 310 LEU   B CA  1 
ATOM   4366 C  C   . LEU   B 1 310 ? -26.22311 -6.43986  -61.34657 1.000 28.71970 ? 310 LEU   B C   1 
ATOM   4367 O  O   . LEU   B 1 310 ? -26.16362 -5.51069  -62.15526 1.000 35.12715 ? 310 LEU   B O   1 
ATOM   4368 C  CB  . LEU   B 1 310 ? -28.44001 -7.30342  -60.55854 1.000 35.49983 ? 310 LEU   B CB  1 
ATOM   4369 C  CG  . LEU   B 1 310 ? -29.60697 -8.25738  -60.81071 1.000 35.08426 ? 310 LEU   B CG  1 
ATOM   4370 C  CD1 . LEU   B 1 310 ? -30.65696 -8.09376  -59.73444 1.000 33.85363 ? 310 LEU   B CD1 1 
ATOM   4371 C  CD2 . LEU   B 1 310 ? -30.21256 -7.98183  -62.17521 1.000 30.47570 ? 310 LEU   B CD2 1 
ATOM   4372 N  N   . GLN   B 1 311 ? -25.39563 -6.53399  -60.30980 1.000 24.36905 ? 311 GLN   B N   1 
ATOM   4373 C  CA  . GLN   B 1 311 ? -24.26740 -5.62641  -60.16423 1.000 31.20204 ? 311 GLN   B CA  1 
ATOM   4374 C  C   . GLN   B 1 311 ? -23.42384 -5.60304  -61.43497 1.000 29.41779 ? 311 GLN   B C   1 
ATOM   4375 O  O   . GLN   B 1 311 ? -23.22161 -4.54567  -62.04190 1.000 22.26008 ? 311 GLN   B O   1 
ATOM   4376 C  CB  . GLN   B 1 311 ? -23.43122 -6.02969  -58.94424 1.000 23.81703 ? 311 GLN   B CB  1 
ATOM   4377 C  CG  . GLN   B 1 311 ? -24.16388 -5.82492  -57.63614 1.000 20.81453 ? 311 GLN   B CG  1 
ATOM   4378 C  CD  . GLN   B 1 311 ? -23.35610 -6.28629  -56.44040 1.000 26.69601 ? 311 GLN   B CD  1 
ATOM   4379 O  OE1 . GLN   B 1 311 ? -22.81790 -7.39851  -56.41228 1.000 24.28789 ? 311 GLN   B OE1 1 
ATOM   4380 N  NE2 . GLN   B 1 311 ? -23.26689 -5.42811  -55.43712 1.000 31.02995 ? 311 GLN   B NE2 1 
ATOM   4381 N  N   . ASN   B 1 312 ? -22.95538 -6.77293  -61.87629 1.000 26.03186 ? 312 ASN   B N   1 
ATOM   4382 C  CA  . ASN   B 1 312 ? -22.15887 -6.81892  -63.09634 1.000 33.67829 ? 312 ASN   B CA  1 
ATOM   4383 C  C   . ASN   B 1 312 ? -22.94426 -6.40622  -64.32690 1.000 31.72253 ? 312 ASN   B C   1 
ATOM   4384 O  O   . ASN   B 1 312 ? -22.33641 -5.99179  -65.31911 1.000 28.36551 ? 312 ASN   B O   1 
ATOM   4385 C  CB  . ASN   B 1 312 ? -21.58404 -8.20623  -63.31956 1.000 26.98356 ? 312 ASN   B CB  1 
ATOM   4386 C  CG  . ASN   B 1 312 ? -20.33751 -8.42239  -62.54356 1.000 23.86911 ? 312 ASN   B CG  1 
ATOM   4387 O  OD1 . ASN   B 1 312 ? -19.24391 -8.13443  -63.01843 1.000 29.56407 ? 312 ASN   B OD1 1 
ATOM   4388 N  ND2 . ASN   B 1 312 ? -20.48115 -8.92331  -61.32577 1.000 34.65850 ? 312 ASN   B ND2 1 
ATOM   4389 N  N   . MET   B 1 313 ? -24.26824 -6.49331  -64.28717 1.000 25.24413 ? 313 MET   B N   1 
ATOM   4390 C  CA  . MET   B 1 313 ? -25.03345 -6.14651  -65.47306 1.000 27.13127 ? 313 MET   B CA  1 
ATOM   4391 C  C   . MET   B 1 313 ? -25.20274 -4.63902  -65.59781 1.000 29.84963 ? 313 MET   B C   1 
ATOM   4392 O  O   . MET   B 1 313 ? -25.11644 -4.08959  -66.70222 1.000 25.73476 ? 313 MET   B O   1 
ATOM   4393 C  CB  . MET   B 1 313 ? -26.39797 -6.82929  -65.44742 1.000 27.33358 ? 313 MET   B CB  1 
ATOM   4394 C  CG  . MET   B 1 313 ? -27.40945 -6.16125  -66.34283 1.000 22.83124 ? 313 MET   B CG  1 
ATOM   4395 S  SD  . MET   B 1 313 ? -29.01067 -6.93778  -66.26862 1.000 37.02792 ? 313 MET   B SD  1 
ATOM   4396 C  CE  . MET   B 1 313 ? -28.51994 -8.63169  -66.00561 1.000 18.79237 ? 313 MET   B CE  1 
ATOM   4397 N  N   . VAL   B 1 314 ? -25.47033 -3.95375  -64.48862 1.000 25.25662 ? 314 VAL   B N   1 
ATOM   4398 C  CA  . VAL   B 1 314 ? -25.54384 -2.50558  -64.57914 1.000 22.32938 ? 314 VAL   B CA  1 
ATOM   4399 C  C   . VAL   B 1 314 ? -24.14521 -1.92956  -64.69355 1.000 20.99533 ? 314 VAL   B C   1 
ATOM   4400 O  O   . VAL   B 1 314 ? -23.95253 -0.86184  -65.28582 1.000 17.76614 ? 314 VAL   B O   1 
ATOM   4401 C  CB  . VAL   B 1 314 ? -26.31437 -1.93076  -63.39142 1.000 16.75545 ? 314 VAL   B CB  1 
ATOM   4402 C  CG1 . VAL   B 1 314 ? -26.60205 -0.46531  -63.62638 1.000 20.21083 ? 314 VAL   B CG1 1 
ATOM   4403 C  CG2 . VAL   B 1 314 ? -27.59736 -2.69906  -63.19226 1.000 19.21290 ? 314 VAL   B CG2 1 
ATOM   4404 N  N   . HIS   B 1 315 ? -23.15060 -2.63419  -64.16004 1.000 15.70910 ? 315 HIS   B N   1 
ATOM   4405 C  CA  . HIS   B 1 315 ? -21.77860 -2.26374  -64.43601 1.000 17.26718 ? 315 HIS   B CA  1 
ATOM   4406 C  C   . HIS   B 1 315 ? -21.50850 -2.34909  -65.93347 1.000 23.91368 ? 315 HIS   B C   1 
ATOM   4407 O  O   . HIS   B 1 315 ? -20.87990 -1.45485  -66.50656 1.000 25.67238 ? 315 HIS   B O   1 
ATOM   4408 C  CB  . HIS   B 1 315 ? -20.83513 -3.14925  -63.63048 1.000 16.90698 ? 315 HIS   B CB  1 
ATOM   4409 C  CG  . HIS   B 1 315 ? -19.39612 -2.73625  -63.69348 1.000 14.91225 ? 315 HIS   B CG  1 
ATOM   4410 N  ND1 . HIS   B 1 315 ? -18.97587 -1.43421  -63.50776 1.000 17.40507 ? 315 HIS   B ND1 1 
ATOM   4411 C  CD2 . HIS   B 1 315 ? -18.27714 -3.46055  -63.92887 1.000 14.62597 ? 315 HIS   B CD2 1 
ATOM   4412 C  CE1 . HIS   B 1 315 ? -17.65999 -1.37654  -63.61274 1.000 17.36211 ? 315 HIS   B CE1 1 
ATOM   4413 N  NE2 . HIS   B 1 315 ? -17.21182 -2.59428  -63.87096 1.000 22.09421 ? 315 HIS   B NE2 1 
ATOM   4414 N  N   . CYS   B 1 316 ? -22.03839 -3.38548  -66.59066 1.000 26.42595 ? 316 CYS   B N   1 
ATOM   4415 C  CA  . CYS   B 1 316 ? -22.00048 -3.48148  -68.05112 1.000 24.56249 ? 316 CYS   B CA  1 
ATOM   4416 C  C   . CYS   B 1 316 ? -22.68341 -2.29672  -68.71183 1.000 24.80375 ? 316 CYS   B C   1 
ATOM   4417 O  O   . CYS   B 1 316 ? -22.08613 -1.59370  -69.53333 1.000 27.16775 ? 316 CYS   B O   1 
ATOM   4418 C  CB  . CYS   B 1 316 ? -22.68150 -4.76419  -68.50620 1.000 24.12813 ? 316 CYS   B CB  1 
ATOM   4419 S  SG  . CYS   B 1 316 ? -21.64083 -6.15927  -68.36677 1.000 23.25000 ? 316 CYS   B SG  1 
ATOM   4420 N  N   . ALA   B 1 317 ? -23.95863 -2.08257  -68.39134 1.000 22.61592 ? 317 ALA   B N   1 
ATOM   4421 C  CA  . ALA   B 1 317 ? -24.66615 -0.93648  -68.93773 1.000 24.99081 ? 317 ALA   B CA  1 
ATOM   4422 C  C   . ALA   B 1 317 ? -23.95734 0.38240   -68.64409 1.000 27.90307 ? 317 ALA   B C   1 
ATOM   4423 O  O   . ALA   B 1 317 ? -24.22903 1.37715   -69.32258 1.000 24.76991 ? 317 ALA   B O   1 
ATOM   4424 C  CB  . ALA   B 1 317 ? -26.08844 -0.89502  -68.39258 1.000 28.81499 ? 317 ALA   B CB  1 
ATOM   4425 N  N   . ASP   B 1 318 ? -23.08619 0.41930   -67.63457 1.000 21.34000 ? 318 ASP   B N   1 
ATOM   4426 C  CA  . ASP   B 1 318 ? -22.29784 1.61373   -67.34622 1.000 23.41938 ? 318 ASP   B CA  1 
ATOM   4427 C  C   . ASP   B 1 318 ? -21.07914 1.66269   -68.24653 1.000 21.66598 ? 318 ASP   B C   1 
ATOM   4428 O  O   . ASP   B 1 318 ? -20.67431 2.73808   -68.69813 1.000 26.58198 ? 318 ASP   B O   1 
ATOM   4429 C  CB  . ASP   B 1 318 ? -21.87617 1.62488   -65.86803 1.000 24.23019 ? 318 ASP   B CB  1 
ATOM   4430 C  CG  . ASP   B 1 318 ? -21.51310 3.01211   -65.35139 1.000 20.25103 ? 318 ASP   B CG  1 
ATOM   4431 O  OD1 . ASP   B 1 318 ? -22.07914 4.02820   -65.82832 1.000 17.99664 ? 318 ASP   B OD1 1 
ATOM   4432 O  OD2 . ASP   B 1 318 ? -20.65327 3.07606   -64.43897 1.000 20.88051 ? 318 ASP   B OD2 1 
ATOM   4433 N  N   . LEU   B 1 319 ? -20.50940 0.50340   -68.54212 1.000 22.51780 ? 319 LEU   B N   1 
ATOM   4434 C  CA  . LEU   B 1 319 ? -19.35724 0.37465   -69.42013 1.000 17.57334 ? 319 LEU   B CA  1 
ATOM   4435 C  C   . LEU   B 1 319 ? -19.74210 -0.19277  -70.78485 1.000 17.24633 ? 319 LEU   B C   1 
ATOM   4436 O  O   . LEU   B 1 319 ? -19.02153 -1.00408  -71.35863 1.000 21.55549 ? 319 LEU   B O   1 
ATOM   4437 C  CB  . LEU   B 1 319 ? -18.28487 -0.48151  -68.75510 1.000 18.61604 ? 319 LEU   B CB  1 
ATOM   4438 C  CG  . LEU   B 1 319 ? -17.79678 0.05733   -67.39863 1.000 17.95089 ? 319 LEU   B CG  1 
ATOM   4439 C  CD1 . LEU   B 1 319 ? -16.70861 -0.81062  -66.82462 1.000 16.80556 ? 319 LEU   B CD1 1 
ATOM   4440 C  CD2 . LEU   B 1 319 ? -17.27636 1.47758   -67.57202 1.000 24.60786 ? 319 LEU   B CD2 1 
ATOM   4441 N  N   . SER   B 1 320 ? -20.87237 0.25201   -71.33327 1.000 19.42612 ? 320 SER   B N   1 
ATOM   4442 C  CA  . SER   B 1 320 ? -21.36389 -0.25808  -72.60394 1.000 24.46247 ? 320 SER   B CA  1 
ATOM   4443 C  C   . SER   B 1 320 ? -21.10833 0.67735   -73.77827 1.000 27.27401 ? 320 SER   B C   1 
ATOM   4444 O  O   . SER   B 1 320 ? -21.28061 0.25306   -74.92367 1.000 28.75660 ? 320 SER   B O   1 
ATOM   4445 C  CB  . SER   B 1 320 ? -22.86460 -0.53149  -72.52081 1.000 20.35578 ? 320 SER   B CB  1 
ATOM   4446 O  OG  . SER   B 1 320 ? -23.58806 0.68340   -72.53716 1.000 26.10677 ? 320 SER   B OG  1 
ATOM   4447 N  N   . ASN   B 1 321 ? -20.72804 1.93192   -73.53432 1.000 26.21009 ? 321 ASN   B N   1 
ATOM   4448 C  CA  . ASN   B 1 321 ? -20.45582 2.84397   -74.64598 1.000 26.48398 ? 321 ASN   B CA  1 
ATOM   4449 C  C   . ASN   B 1 321 ? -19.61652 2.20976   -75.75430 1.000 21.51583 ? 321 ASN   B C   1 
ATOM   4450 O  O   . ASN   B 1 321 ? -20.01562 2.30771   -76.92353 1.000 21.49439 ? 321 ASN   B O   1 
ATOM   4451 C  CB  . ASN   B 1 321 ? -19.77371 4.12655   -74.14839 1.000 20.76736 ? 321 ASN   B CB  1 
ATOM   4452 C  CG  . ASN   B 1 321 ? -20.66232 4.98755   -73.26764 1.000 24.88426 ? 321 ASN   B CG  1 
ATOM   4453 O  OD1 . ASN   B 1 321 ? -20.15972 5.89061   -72.61765 1.000 22.60311 ? 321 ASN   B OD1 1 
ATOM   4454 N  ND2 . ASN   B 1 321 ? -21.96909 4.72987   -73.24722 1.000 21.88554 ? 321 ASN   B ND2 1 
ATOM   4455 N  N   . PRO   B 1 322 ? -18.47918 1.55517   -75.48464 1.000 20.15206 ? 322 PRO   B N   1 
ATOM   4456 C  CA  . PRO   B 1 322 ? -17.67117 1.03105   -76.59635 1.000 22.28737 ? 322 PRO   B CA  1 
ATOM   4457 C  C   . PRO   B 1 322 ? -18.25658 -0.18956  -77.29728 1.000 30.88028 ? 322 PRO   B C   1 
ATOM   4458 O  O   . PRO   B 1 322 ? -17.56512 -0.81693  -78.10938 1.000 25.74236 ? 322 PRO   B O   1 
ATOM   4459 C  CB  . PRO   B 1 322 ? -16.33818 0.67898   -75.92472 1.000 18.20762 ? 322 PRO   B CB  1 
ATOM   4460 C  CG  . PRO   B 1 322 ? -16.35072 1.42711   -74.61786 1.000 16.60768 ? 322 PRO   B CG  1 
ATOM   4461 C  CD  . PRO   B 1 322 ? -17.76620 1.42339   -74.20196 1.000 23.34334 ? 322 PRO   B CD  1 
ATOM   4462 N  N   . THR   B 1 323 ? -19.50273 -0.55138  -76.97477 1.000 31.31457 ? 323 THR   B N   1 
ATOM   4463 C  CA  . THR   B 1 323 ? -20.21736 -1.63299  -77.64391 1.000 30.66772 ? 323 THR   B CA  1 
ATOM   4464 C  C   . THR   B 1 323 ? -21.42429 -1.12995  -78.41495 1.000 25.50708 ? 323 THR   B C   1 
ATOM   4465 O  O   . THR   B 1 323 ? -22.15607 -1.93721  -78.98372 1.000 33.54597 ? 323 THR   B O   1 
ATOM   4466 C  CB  . THR   B 1 323 ? -20.69150 -2.71448  -76.64277 1.000 32.42656 ? 323 THR   B CB  1 
ATOM   4467 O  OG1 . THR   B 1 323 ? -21.81921 -2.23456  -75.88563 1.000 23.00168 ? 323 THR   B OG1 1 
ATOM   4468 C  CG2 . THR   B 1 323 ? -19.57258 -3.15352  -75.71033 1.000 22.24377 ? 323 THR   B CG2 1 
ATOM   4469 N  N   . LYS   B 1 324 ? -21.67668 0.16369   -78.42042 1.000 28.00382 ? 324 LYS   B N   1 
ATOM   4470 C  CA  . LYS   B 1 324 ? -22.77228 0.71986   -79.20020 1.000 34.84743 ? 324 LYS   B CA  1 
ATOM   4471 C  C   . LYS   B 1 324 ? -22.32589 0.87508   -80.65591 1.000 33.59733 ? 324 LYS   B C   1 
ATOM   4472 O  O   . LYS   B 1 324 ? -21.22106 0.47547   -81.04506 1.000 32.67257 ? 324 LYS   B O   1 
ATOM   4473 C  CB  . LYS   B 1 324 ? -23.23618 2.02594   -78.56091 1.000 34.61649 ? 324 LYS   B CB  1 
ATOM   4474 C  CG  . LYS   B 1 324 ? -23.77669 1.86806   -77.12309 1.000 29.02395 ? 324 LYS   B CG  1 
ATOM   4475 C  CD  . LYS   B 1 324 ? -25.01033 0.94931   -77.03970 1.000 33.06879 ? 324 LYS   B CD  1 
ATOM   4476 C  CE  . LYS   B 1 324 ? -25.55488 0.86142   -75.60509 1.000 27.23900 ? 324 LYS   B CE  1 
ATOM   4477 N  NZ  . LYS   B 1 324 ? -26.12233 2.15393   -75.10044 1.000 23.24704 ? 324 LYS   B NZ  1 
ATOM   4478 N  N   . PRO   B 1 325 ? -23.20723 1.36175   -81.53136 1.000 39.02282 ? 325 PRO   B N   1 
ATOM   4479 C  CA  . PRO   B 1 325 ? -22.75797 1.76498   -82.87183 1.000 33.57550 ? 325 PRO   B CA  1 
ATOM   4480 C  C   . PRO   B 1 325 ? -21.79841 2.95000   -82.82458 1.000 27.50801 ? 325 PRO   B C   1 
ATOM   4481 O  O   . PRO   B 1 325 ? -22.00376 3.91732   -82.08357 1.000 26.20545 ? 325 PRO   B O   1 
ATOM   4482 C  CB  . PRO   B 1 325 ? -24.06274 2.13089   -83.58603 1.000 34.05959 ? 325 PRO   B CB  1 
ATOM   4483 C  CG  . PRO   B 1 325 ? -25.10800 1.31254   -82.90306 1.000 38.75885 ? 325 PRO   B CG  1 
ATOM   4484 C  CD  . PRO   B 1 325 ? -24.66914 1.14128   -81.47866 1.000 35.81733 ? 325 PRO   B CD  1 
ATOM   4485 N  N   . LEU   B 1 326 ? -20.77827 2.88219   -83.68683 1.000 32.46967 ? 326 LEU   B N   1 
ATOM   4486 C  CA  . LEU   B 1 326 ? -19.65763 3.82500   -83.66960 1.000 28.59980 ? 326 LEU   B CA  1 
ATOM   4487 C  C   . LEU   B 1 326 ? -20.11163 5.27421   -83.50373 1.000 31.81596 ? 326 LEU   B C   1 
ATOM   4488 O  O   . LEU   B 1 326 ? -19.54948 6.02395   -82.69760 1.000 28.54489 ? 326 LEU   B O   1 
ATOM   4489 C  CB  . LEU   B 1 326 ? -18.83962 3.65750   -84.95449 1.000 29.55266 ? 326 LEU   B CB  1 
ATOM   4490 C  CG  . LEU   B 1 326 ? -17.43984 4.27028   -84.97782 1.000 29.00822 ? 326 LEU   B CG  1 
ATOM   4491 C  CD1 . LEU   B 1 326 ? -16.73942 4.04477   -83.63397 1.000 23.33000 ? 326 LEU   B CD1 1 
ATOM   4492 C  CD2 . LEU   B 1 326 ? -16.62466 3.66559   -86.10655 1.000 22.40189 ? 326 LEU   B CD2 1 
ATOM   4493 N  N   . GLN   B 1 327 ? -21.13449 5.68353   -84.25997 1.000 29.46428 ? 327 GLN   B N   1 
ATOM   4494 C  CA  . GLN   B 1 327 ? -21.63793 7.04878   -84.16321 1.000 32.61629 ? 327 GLN   B CA  1 
ATOM   4495 C  C   . GLN   B 1 327 ? -22.03079 7.39751   -82.74034 1.000 30.84945 ? 327 GLN   B C   1 
ATOM   4496 O  O   . GLN   B 1 327 ? -21.94399 8.56597   -82.33469 1.000 26.84043 ? 327 GLN   B O   1 
ATOM   4497 C  CB  . GLN   B 1 327 ? -22.84476 7.23719   -85.09006 1.000 34.27274 ? 327 GLN   B CB  1 
ATOM   4498 C  CG  . GLN   B 1 327 ? -22.62925 6.72958   -86.50782 1.000 50.88251 ? 327 GLN   B CG  1 
ATOM   4499 C  CD  . GLN   B 1 327 ? -22.52980 7.85124   -87.52951 1.000 52.27056 ? 327 GLN   B CD  1 
ATOM   4500 O  OE1 . GLN   B 1 327 ? -21.52780 8.59207   -87.57675 1.000 56.53413 ? 327 GLN   B OE1 1 
ATOM   4501 N  NE2 . GLN   B 1 327 ? -23.57209 7.98267   -88.36227 1.000 51.16241 ? 327 GLN   B NE2 1 
ATOM   4502 N  N   . LEU   B 1 328 ? -22.49899 6.40563   -81.98024 1.000 32.39375 ? 328 LEU   B N   1 
ATOM   4503 C  CA  . LEU   B 1 328 ? -22.86850 6.63660   -80.58740 1.000 30.36094 ? 328 LEU   B CA  1 
ATOM   4504 C  C   . LEU   B 1 328 ? -21.62763 6.59159   -79.70920 1.000 26.31320 ? 328 LEU   B C   1 
ATOM   4505 O  O   . LEU   B 1 328 ? -21.39061 7.49558   -78.89992 1.000 26.08967 ? 328 LEU   B O   1 
ATOM   4506 C  CB  . LEU   B 1 328 ? -23.91608 5.60161   -80.13218 1.000 31.46609 ? 328 LEU   B CB  1 
ATOM   4507 C  CG  . LEU   B 1 328 ? -25.29980 5.60990   -80.81973 1.000 30.92505 ? 328 LEU   B CG  1 
ATOM   4508 C  CD1 . LEU   B 1 328 ? -26.23841 4.53293   -80.29452 1.000 26.65064 ? 328 LEU   B CD1 1 
ATOM   4509 C  CD2 . LEU   B 1 328 ? -25.96693 6.96371   -80.70701 1.000 40.13240 ? 328 LEU   B CD2 1 
ATOM   4510 N  N   . TYR   B 1 329 ? -20.80163 5.56980   -79.91286 1.000 16.42537 ? 329 TYR   B N   1 
ATOM   4511 C  CA  . TYR   B 1 329 ? -19.58730 5.41416   -79.13317 1.000 20.43027 ? 329 TYR   B CA  1 
ATOM   4512 C  C   . TYR   B 1 329 ? -18.70093 6.64361   -79.26016 1.000 20.98206 ? 329 TYR   B C   1 
ATOM   4513 O  O   . TYR   B 1 329 ? -18.27792 7.22750   -78.25325 1.000 21.60181 ? 329 TYR   B O   1 
ATOM   4514 C  CB  . TYR   B 1 329 ? -18.86834 4.15246   -79.60185 1.000 15.04011 ? 329 TYR   B CB  1 
ATOM   4515 C  CG  . TYR   B 1 329 ? -17.57475 3.83165   -78.90951 1.000 18.11029 ? 329 TYR   B CG  1 
ATOM   4516 C  CD1 . TYR   B 1 329 ? -17.21868 4.42698   -77.68688 1.000 20.09926 ? 329 TYR   B CD1 1 
ATOM   4517 C  CD2 . TYR   B 1 329 ? -16.68956 2.93117   -79.48520 1.000 11.58190 ? 329 TYR   B CD2 1 
ATOM   4518 C  CE1 . TYR   B 1 329 ? -16.00185 4.12891   -77.07866 1.000 14.40310 ? 329 TYR   B CE1 1 
ATOM   4519 C  CE2 . TYR   B 1 329 ? -15.50586 2.63178   -78.89401 1.000 13.72611 ? 329 TYR   B CE2 1 
ATOM   4520 C  CZ  . TYR   B 1 329 ? -15.15243 3.22768   -77.69721 1.000 16.33354 ? 329 TYR   B CZ  1 
ATOM   4521 O  OH  . TYR   B 1 329 ? -13.95055 2.88421   -77.13227 1.000 14.37136 ? 329 TYR   B OH  1 
ATOM   4522 N  N   . ARG   B 1 330 ? -18.42405 7.05905   -80.49746 1.000 27.36250 ? 330 ARG   B N   1 
ATOM   4523 C  CA  . ARG   B 1 330 ? -17.58076 8.22953   -80.72532 1.000 28.67917 ? 330 ARG   B CA  1 
ATOM   4524 C  C   . ARG   B 1 330 ? -18.06733 9.42113   -79.93084 1.000 18.96689 ? 330 ARG   B C   1 
ATOM   4525 O  O   . ARG   B 1 330 ? -17.26150 10.19337  -79.40232 1.000 21.64246 ? 330 ARG   B O   1 
ATOM   4526 C  CB  . ARG   B 1 330 ? -17.55657 8.58635   -82.20828 1.000 26.66547 ? 330 ARG   B CB  1 
ATOM   4527 C  CG  . ARG   B 1 330 ? -16.69353 7.68396   -83.04128 1.000 26.30063 ? 330 ARG   B CG  1 
ATOM   4528 C  CD  . ARG   B 1 330 ? -15.79617 8.53860   -83.90395 1.000 32.28896 ? 330 ARG   B CD  1 
ATOM   4529 N  NE  . ARG   B 1 330 ? -16.25963 8.55027   -85.27689 1.000 39.42141 ? 330 ARG   B NE  1 
ATOM   4530 C  CZ  . ARG   B 1 330 ? -15.90980 9.45401   -86.18184 1.000 42.35751 ? 330 ARG   B CZ  1 
ATOM   4531 N  NH1 . ARG   B 1 330 ? -15.07750 10.44434  -85.86363 1.000 39.22789 ? 330 ARG   B NH1 1 
ATOM   4532 N  NH2 . ARG   B 1 330 ? -16.40339 9.36082   -87.40788 1.000 40.75314 ? 330 ARG   B NH2 1 
ATOM   4533 N  N   . GLN   B 1 331 ? -19.38872 9.58352   -79.83726 1.000 19.94528 ? 331 GLN   B N   1 
ATOM   4534 C  CA  . GLN   B 1 331 ? -19.96302 10.76721  -79.20958 1.000 24.91837 ? 331 GLN   B CA  1 
ATOM   4535 C  C   . GLN   B 1 331 ? -19.90311 10.68322  -77.68673 1.000 25.99316 ? 331 GLN   B C   1 
ATOM   4536 O  O   . GLN   B 1 331 ? -19.68283 11.70544  -77.02353 1.000 25.45986 ? 331 GLN   B O   1 
ATOM   4537 C  CB  . GLN   B 1 331 ? -21.39791 10.98635  -79.71413 1.000 26.95033 ? 331 GLN   B CB  1 
ATOM   4538 C  CG  . GLN   B 1 331 ? -22.31215 11.76156  -78.76457 1.000 35.69011 ? 331 GLN   B CG  1 
ATOM   4539 C  CD  . GLN   B 1 331 ? -22.36980 13.25354  -79.05487 1.000 37.59848 ? 331 GLN   B CD  1 
ATOM   4540 O  OE1 . GLN   B 1 331 ? -21.46327 13.83107  -79.72161 1.000 45.03538 ? 331 GLN   B OE1 1 
ATOM   4541 N  NE2 . GLN   B 1 331 ? -23.43550 13.90492  -78.53435 1.000 36.29603 ? 331 GLN   B NE2 1 
ATOM   4542 N  N   . TRP   B 1 332 ? -20.05971 9.48410   -77.11711 1.000 25.13497 ? 332 TRP   B N   1 
ATOM   4543 C  CA  . TRP   B 1 332 ? -19.73379 9.30514   -75.70575 1.000 22.60838 ? 332 TRP   B CA  1 
ATOM   4544 C  C   . TRP   B 1 332 ? -18.26907 9.63607   -75.45256 1.000 21.63933 ? 332 TRP   B C   1 
ATOM   4545 O  O   . TRP   B 1 332 ? -17.94259 10.37441  -74.51647 1.000 22.08963 ? 332 TRP   B O   1 
ATOM   4546 C  CB  . TRP   B 1 332 ? -20.06199 7.87381   -75.25006 1.000 24.44706 ? 332 TRP   B CB  1 
ATOM   4547 C  CG  . TRP   B 1 332 ? -21.54726 7.56981   -75.24336 1.000 15.28637 ? 332 TRP   B CG  1 
ATOM   4548 C  CD1 . TRP   B 1 332 ? -22.18406 6.60460   -75.95192 1.000 20.76240 ? 332 TRP   B CD1 1 
ATOM   4549 C  CD2 . TRP   B 1 332 ? -22.56158 8.26304   -74.51242 1.000 18.32315 ? 332 TRP   B CD2 1 
ATOM   4550 N  NE1 . TRP   B 1 332 ? -23.53678 6.64841   -75.70973 1.000 23.34981 ? 332 TRP   B NE1 1 
ATOM   4551 C  CE2 . TRP   B 1 332 ? -23.79392 7.65694   -74.82488 1.000 19.85798 ? 332 TRP   B CE2 1 
ATOM   4552 C  CE3 . TRP   B 1 332 ? -22.54878 9.32861   -73.60913 1.000 21.46266 ? 332 TRP   B CE3 1 
ATOM   4553 C  CZ2 . TRP   B 1 332 ? -25.00291 8.08377   -74.26936 1.000 18.16837 ? 332 TRP   B CZ2 1 
ATOM   4554 C  CZ3 . TRP   B 1 332 ? -23.75119 9.75252   -73.05496 1.000 18.84510 ? 332 TRP   B CZ3 1 
ATOM   4555 C  CH2 . TRP   B 1 332 ? -24.95949 9.13586   -73.39365 1.000 20.18226 ? 332 TRP   B CH2 1 
ATOM   4556 N  N   . THR   B 1 333 ? -17.36875 9.11088   -76.29618 1.000 24.45034 ? 333 THR   B N   1 
ATOM   4557 C  CA  . THR   B 1 333 ? -15.94402 9.39915   -76.14347 1.000 20.27385 ? 333 THR   B CA  1 
ATOM   4558 C  C   . THR   B 1 333 ? -15.68073 10.89692  -76.14439 1.000 20.45369 ? 333 THR   B C   1 
ATOM   4559 O  O   . THR   B 1 333 ? -14.89309 11.40111  -75.33808 1.000 17.78257 ? 333 THR   B O   1 
ATOM   4560 C  CB  . THR   B 1 333 ? -15.14149 8.74791   -77.25861 1.000 17.94237 ? 333 THR   B CB  1 
ATOM   4561 O  OG1 . THR   B 1 333 ? -15.27795 7.33025   -77.17792 1.000 23.21912 ? 333 THR   B OG1 1 
ATOM   4562 C  CG2 . THR   B 1 333 ? -13.65608 9.12617   -77.11875 1.000 13.15883 ? 333 THR   B CG2 1 
ATOM   4563 N  N   . ASP   B 1 334 ? -16.30261 11.61589  -77.08320 1.000 22.97576 ? 334 ASP   B N   1 
ATOM   4564 C  CA  . ASP   B 1 334 ? -16.19406 13.06559  -77.09764 1.000 19.28845 ? 334 ASP   B CA  1 
ATOM   4565 C  C   . ASP   B 1 334 ? -16.66716 13.63720  -75.77791 1.000 22.64176 ? 334 ASP   B C   1 
ATOM   4566 O  O   . ASP   B 1 334 ? -16.01870 14.52462  -75.21209 1.000 22.47816 ? 334 ASP   B O   1 
ATOM   4567 C  CB  . ASP   B 1 334 ? -17.01792 13.65405  -78.24579 1.000 25.25514 ? 334 ASP   B CB  1 
ATOM   4568 C  CG  . ASP   B 1 334 ? -16.23347 13.77128  -79.55370 1.000 34.04434 ? 334 ASP   B CG  1 
ATOM   4569 O  OD1 . ASP   B 1 334 ? -15.18804 13.09799  -79.71705 1.000 35.69185 ? 334 ASP   B OD1 1 
ATOM   4570 O  OD2 . ASP   B 1 334 ? -16.69454 14.53014  -80.43541 1.000 31.44798 ? 334 ASP   B OD2 1 
ATOM   4571 N  N   . ARG   B 1 335 ? -17.78867 13.12152  -75.25971 1.000 19.06208 ? 335 ARG   B N   1 
ATOM   4572 C  CA  . ARG   B 1 335 ? -18.35401 13.67210  -74.03208 1.000 19.28906 ? 335 ARG   B CA  1 
ATOM   4573 C  C   . ARG   B 1 335 ? -17.49538 13.34644  -72.81700 1.000 18.94958 ? 335 ARG   B C   1 
ATOM   4574 O  O   . ARG   B 1 335 ? -17.26617 14.22037  -71.97253 1.000 17.45234 ? 335 ARG   B O   1 
ATOM   4575 C  CB  . ARG   B 1 335 ? -19.78875 13.17905  -73.84262 1.000 19.30079 ? 335 ARG   B CB  1 
ATOM   4576 C  CG  . ARG   B 1 335 ? -20.79789 14.00039  -74.65801 1.000 22.89095 ? 335 ARG   B CG  1 
ATOM   4577 C  CD  . ARG   B 1 335 ? -22.09169 13.24678  -74.83784 1.000 21.63133 ? 335 ARG   B CD  1 
ATOM   4578 N  NE  . ARG   B 1 335 ? -23.09620 13.98950  -75.58875 1.000 23.30745 ? 335 ARG   B NE  1 
ATOM   4579 C  CZ  . ARG   B 1 335 ? -23.81073 14.99720  -75.10353 1.000 24.92709 ? 335 ARG   B CZ  1 
ATOM   4580 N  NH1 . ARG   B 1 335 ? -23.63076 15.41847  -73.85502 1.000 31.96963 ? 335 ARG   B NH1 1 
ATOM   4581 N  NH2 . ARG   B 1 335 ? -24.71245 15.59028  -75.86726 1.000 27.83786 ? 335 ARG   B NH2 1 
ATOM   4582 N  N   . ILE   B 1 336 ? -17.00120 12.10623  -72.70762 1.000 19.31157 ? 336 ILE   B N   1 
ATOM   4583 C  CA  . ILE   B 1 336 ? -16.20474 11.75804  -71.53523 1.000 15.60780 ? 336 ILE   B CA  1 
ATOM   4584 C  C   . ILE   B 1 336 ? -14.89128 12.52489  -71.55043 1.000 18.83335 ? 336 ILE   B C   1 
ATOM   4585 O  O   . ILE   B 1 336 ? -14.38923 12.94016  -70.50047 1.000 22.80706 ? 336 ILE   B O   1 
ATOM   4586 C  CB  . ILE   B 1 336 ? -15.97314 10.23271  -71.43397 1.000 17.41025 ? 336 ILE   B CB  1 
ATOM   4587 C  CG1 . ILE   B 1 336 ? -15.45749 9.86623   -70.03751 1.000 17.17501 ? 336 ILE   B CG1 1 
ATOM   4588 C  CG2 . ILE   B 1 336 ? -14.94954 9.74252   -72.44722 1.000 15.14668 ? 336 ILE   B CG2 1 
ATOM   4589 C  CD1 . ILE   B 1 336 ? -16.43809 10.15887  -68.91813 1.000 13.74474 ? 336 ILE   B CD1 1 
ATOM   4590 N  N   . MET   B 1 337 ? -14.32085 12.74491  -72.73393 1.000 16.82067 ? 337 MET   B N   1 
ATOM   4591 C  CA  . MET   B 1 337 ? -13.04477 13.44235  -72.78809 1.000 21.50047 ? 337 MET   B CA  1 
ATOM   4592 C  C   . MET   B 1 337 ? -13.21335 14.91571  -72.45527 1.000 22.50156 ? 337 MET   B C   1 
ATOM   4593 O  O   . MET   B 1 337 ? -12.36702 15.50020  -71.76914 1.000 20.52841 ? 337 MET   B O   1 
ATOM   4594 C  CB  . MET   B 1 337 ? -12.39390 13.26993  -74.16017 1.000 23.64182 ? 337 MET   B CB  1 
ATOM   4595 C  CG  . MET   B 1 337 ? -11.94909 11.85351  -74.46583 1.000 24.90225 ? 337 MET   B CG  1 
ATOM   4596 S  SD  . MET   B 1 337 ? -10.85175 11.13857  -73.22030 1.000 28.79684 ? 337 MET   B SD  1 
ATOM   4597 C  CE  . MET   B 1 337 ? -9.77319  12.51198  -72.86633 1.000 31.62955 ? 337 MET   B CE  1 
ATOM   4598 N  N   . GLU   B 1 338 ? -14.29774 15.53265  -72.93533 1.000 17.10078 ? 338 GLU   B N   1 
ATOM   4599 C  CA  . GLU   B 1 338 ? -14.61855 16.88458  -72.49997 1.000 21.36722 ? 338 GLU   B CA  1 
ATOM   4600 C  C   . GLU   B 1 338 ? -14.72304 16.95982  -70.97996 1.000 25.80791 ? 338 GLU   B C   1 
ATOM   4601 O  O   . GLU   B 1 338 ? -14.17636 17.87636  -70.35476 1.000 26.67382 ? 338 GLU   B O   1 
ATOM   4602 C  CB  . GLU   B 1 338 ? -15.91521 17.34780  -73.15907 1.000 24.54953 ? 338 GLU   B CB  1 
ATOM   4603 C  CG  . GLU   B 1 338 ? -16.17184 18.83626  -73.02413 1.000 27.84570 ? 338 GLU   B CG  1 
ATOM   4604 C  CD  . GLU   B 1 338 ? -17.30624 19.30663  -73.91224 1.000 45.66893 ? 338 GLU   B CD  1 
ATOM   4605 O  OE1 . GLU   B 1 338 ? -17.15710 19.22567  -75.15091 1.000 51.48483 ? 338 GLU   B OE1 1 
ATOM   4606 O  OE2 . GLU   B 1 338 ? -18.34674 19.75481  -73.37787 1.000 47.42866 ? 338 GLU   B OE2 1 
ATOM   4607 N  N   . GLU   B 1 339 ? -15.38603 15.97982  -70.36330 1.000 20.36301 ? 339 GLU   B N   1 
ATOM   4608 C  CA  . GLU   B 1 339 ? -15.52161 15.98332  -68.91113 1.000 24.47663 ? 339 GLU   B CA  1 
ATOM   4609 C  C   . GLU   B 1 339 ? -14.17738 15.76394  -68.22393 1.000 23.81907 ? 339 GLU   B C   1 
ATOM   4610 O  O   . GLU   B 1 339 ? -13.90500 16.36037  -67.17808 1.000 27.12390 ? 339 GLU   B O   1 
ATOM   4611 C  CB  . GLU   B 1 339 ? -16.52457 14.91429  -68.48227 1.000 18.81026 ? 339 GLU   B CB  1 
ATOM   4612 C  CG  . GLU   B 1 339 ? -16.98516 15.04521  -67.05579 1.000 16.23315 ? 339 GLU   B CG  1 
ATOM   4613 C  CD  . GLU   B 1 339 ? -18.20767 14.16633  -66.74951 1.000 19.07644 ? 339 GLU   B CD  1 
ATOM   4614 O  OE1 . GLU   B 1 339 ? -19.19113 14.17972  -67.52896 1.000 16.02025 ? 339 GLU   B OE1 1 
ATOM   4615 O  OE2 . GLU   B 1 339 ? -18.17341 13.46136  -65.72070 1.000 14.09737 ? 339 GLU   B OE2 1 
ATOM   4616 N  N   . PHE   B 1 340 ? -13.32927 14.90313  -68.78652 1.000 21.75876 ? 340 PHE   B N   1 
ATOM   4617 C  CA  . PHE   B 1 340 ? -12.01970 14.66247  -68.19025 1.000 27.02957 ? 340 PHE   B CA  1 
ATOM   4618 C  C   . PHE   B 1 340 ? -11.08015 15.84728  -68.37790 1.000 27.56503 ? 340 PHE   B C   1 
ATOM   4619 O  O   . PHE   B 1 340 ? -10.22087 16.08940  -67.52942 1.000 24.83780 ? 340 PHE   B O   1 
ATOM   4620 C  CB  . PHE   B 1 340 ? -11.38911 13.40408  -68.78288 1.000 24.45138 ? 340 PHE   B CB  1 
ATOM   4621 C  CG  . PHE   B 1 340 ? -11.93476 12.14055  -68.21640 1.000 28.05666 ? 340 PHE   B CG  1 
ATOM   4622 C  CD1 . PHE   B 1 340 ? -12.99344 12.16801  -67.30595 1.000 23.79911 ? 340 PHE   B CD1 1 
ATOM   4623 C  CD2 . PHE   B 1 340 ? -11.38532 10.92133  -68.57051 1.000 30.59492 ? 340 PHE   B CD2 1 
ATOM   4624 C  CE1 . PHE   B 1 340 ? -13.49744 10.99354  -66.76737 1.000 30.08586 ? 340 PHE   B CE1 1 
ATOM   4625 C  CE2 . PHE   B 1 340 ? -11.87719 9.73962   -68.03110 1.000 35.11891 ? 340 PHE   B CE2 1 
ATOM   4626 C  CZ  . PHE   B 1 340 ? -12.93476 9.77100   -67.12875 1.000 28.06498 ? 340 PHE   B CZ  1 
ATOM   4627 N  N   . PHE   B 1 341 ? -11.20645 16.58158  -69.48325 1.000 28.70630 ? 341 PHE   B N   1 
ATOM   4628 C  CA  . PHE   B 1 341 ? -10.33986 17.73957  -69.67686 1.000 31.03923 ? 341 PHE   B CA  1 
ATOM   4629 C  C   . PHE   B 1 341 ? -10.73725 18.86870  -68.73252 1.000 33.33143 ? 341 PHE   B C   1 
ATOM   4630 O  O   . PHE   B 1 341 ? -9.87102  19.53040  -68.14985 1.000 28.78221 ? 341 PHE   B O   1 
ATOM   4631 C  CB  . PHE   B 1 341 ? -10.38086 18.19652  -71.13655 1.000 32.80564 ? 341 PHE   B CB  1 
ATOM   4632 C  CG  . PHE   B 1 341 ? -9.72774  17.23069  -72.10403 1.000 29.81422 ? 341 PHE   B CG  1 
ATOM   4633 C  CD1 . PHE   B 1 341 ? -8.76151  16.34587  -71.67685 1.000 29.19857 ? 341 PHE   B CD1 1 
ATOM   4634 C  CD2 . PHE   B 1 341 ? -10.08351 17.22579  -73.44830 1.000 25.65759 ? 341 PHE   B CD2 1 
ATOM   4635 C  CE1 . PHE   B 1 341 ? -8.16268  15.47459  -72.56221 1.000 30.64763 ? 341 PHE   B CE1 1 
ATOM   4636 C  CE2 . PHE   B 1 341 ? -9.48996  16.35969  -74.32775 1.000 31.92470 ? 341 PHE   B CE2 1 
ATOM   4637 C  CZ  . PHE   B 1 341 ? -8.52671  15.48213  -73.88359 1.000 30.57626 ? 341 PHE   B CZ  1 
ATOM   4638 N  N   . ARG   B 1 342 ? -12.04668 19.06280  -68.52110 1.000 33.31424 ? 342 ARG   B N   1 
ATOM   4639 C  CA  . ARG   B 1 342 ? -12.50012 20.06424  -67.55976 1.000 33.38879 ? 342 ARG   B CA  1 
ATOM   4640 C  C   . ARG   B 1 342 ? -12.04116 19.75518  -66.14497 1.000 31.50222 ? 342 ARG   B C   1 
ATOM   4641 O  O   . ARG   B 1 342 ? -11.78611 20.67914  -65.37006 1.000 36.68822 ? 342 ARG   B O   1 
ATOM   4642 C  CB  . ARG   B 1 342 ? -14.01814 20.18088  -67.56579 1.000 36.23005 ? 342 ARG   B CB  1 
ATOM   4643 C  CG  . ARG   B 1 342 ? -14.60471 20.73798  -68.83618 1.000 44.51539 ? 342 ARG   B CG  1 
ATOM   4644 C  CD  . ARG   B 1 342 ? -16.11096 20.83322  -68.67724 1.000 48.55257 ? 342 ARG   B CD  1 
ATOM   4645 N  NE  . ARG   B 1 342 ? -16.63122 22.13236  -69.08761 1.000 64.95811 ? 342 ARG   B NE  1 
ATOM   4646 C  CZ  . ARG   B 1 342 ? -16.70325 23.19973  -68.29389 1.000 67.52479 ? 342 ARG   B CZ  1 
ATOM   4647 N  NH1 . ARG   B 1 342 ? -16.27795 23.12874  -67.03923 1.000 62.82154 ? 342 ARG   B NH1 1 
ATOM   4648 N  NH2 . ARG   B 1 342 ? -17.19319 24.34623  -68.75706 1.000 69.30660 ? 342 ARG   B NH2 1 
ATOM   4649 N  N   . GLN   B 1 343 ? -11.97643 18.48009  -65.76395 1.000 25.50096 ? 343 GLN   B N   1 
ATOM   4650 C  CA  . GLN   B 1 343 ? -11.45039 18.17491  -64.43846 1.000 31.48362 ? 343 GLN   B CA  1 
ATOM   4651 C  C   . GLN   B 1 343 ? -9.96223  18.46002  -64.38247 1.000 31.24084 ? 343 GLN   B C   1 
ATOM   4652 O  O   . GLN   B 1 343 ? -9.46147  18.96811  -63.37436 1.000 30.88782 ? 343 GLN   B O   1 
ATOM   4653 C  CB  . GLN   B 1 343 ? -11.73415 16.72069  -64.04769 1.000 22.79815 ? 343 GLN   B CB  1 
ATOM   4654 C  CG  . GLN   B 1 343 ? -10.91015 16.21880  -62.86072 1.000 19.91253 ? 343 GLN   B CG  1 
ATOM   4655 C  CD  . GLN   B 1 343 ? -11.34640 14.84368  -62.39688 1.000 20.89951 ? 343 GLN   B CD  1 
ATOM   4656 O  OE1 . GLN   B 1 343 ? -12.48730 14.43348  -62.62107 1.000 15.38476 ? 343 GLN   B OE1 1 
ATOM   4657 N  NE2 . GLN   B 1 343 ? -10.44243 14.12287  -61.75775 1.000 20.48066 ? 343 GLN   B NE2 1 
ATOM   4658 N  N   . GLY   B 1 344 ? -9.24484  18.13677  -65.45821 1.000 29.72626 ? 344 GLY   B N   1 
ATOM   4659 C  CA  . GLY   B 1 344 ? -7.83920  18.49142  -65.52866 1.000 39.42087 ? 344 GLY   B CA  1 
ATOM   4660 C  C   . GLY   B 1 344 ? -7.61141  19.98879  -65.46684 1.000 31.46351 ? 344 GLY   B C   1 
ATOM   4661 O  O   . GLY   B 1 344 ? -6.65939  20.44984  -64.84167 1.000 41.87933 ? 344 GLY   B O   1 
ATOM   4662 N  N   . ASP   B 1 345 ? -8.47300  20.76879  -66.12577 1.000 33.96702 ? 345 ASP   B N   1 
ATOM   4663 C  CA  . ASP   B 1 345 ? -8.41866  22.21753  -65.95524 1.000 39.27970 ? 345 ASP   B CA  1 
ATOM   4664 C  C   . ASP   B 1 345 ? -8.68460  22.59775  -64.50355 1.000 46.65823 ? 345 ASP   B C   1 
ATOM   4665 O  O   . ASP   B 1 345 ? -7.97720  23.43232  -63.92707 1.000 46.98570 ? 345 ASP   B O   1 
ATOM   4666 C  CB  . ASP   B 1 345 ? -9.42617  22.91312  -66.86869 1.000 35.17048 ? 345 ASP   B CB  1 
ATOM   4667 C  CG  . ASP   B 1 345 ? -9.13932  22.70609  -68.34519 1.000 39.61203 ? 345 ASP   B CG  1 
ATOM   4668 O  OD1 . ASP   B 1 345 ? -8.10011  22.10230  -68.70815 1.000 33.52220 ? 345 ASP   B OD1 1 
ATOM   4669 O  OD2 . ASP   B 1 345 ? -9.98070  23.16025  -69.14702 1.000 35.99908 ? 345 ASP   B OD2 1 
ATOM   4670 N  N   . ARG   B 1 346 ? -9.70823  21.98848  -63.89185 1.000 43.83270 ? 346 ARG   B N   1 
ATOM   4671 C  CA  . ARG   B 1 346 ? -10.01563 22.30737  -62.50424 1.000 39.17246 ? 346 ARG   B CA  1 
ATOM   4672 C  C   . ARG   B 1 346 ? -8.91068  21.83376  -61.56594 1.000 45.62510 ? 346 ARG   B C   1 
ATOM   4673 O  O   . ARG   B 1 346 ? -8.67140  22.47267  -60.54190 1.000 53.77079 ? 346 ARG   B O   1 
ATOM   4674 C  CB  . ARG   B 1 346 ? -11.37308 21.72553  -62.10395 1.000 36.62377 ? 346 ARG   B CB  1 
ATOM   4675 C  CG  . ARG   B 1 346 ? -12.55727 22.36580  -62.82745 1.000 40.75376 ? 346 ARG   B CG  1 
ATOM   4676 C  CD  . ARG   B 1 346 ? -13.66904 22.82459  -61.89011 1.000 49.27269 ? 346 ARG   B CD  1 
ATOM   4677 N  NE  . ARG   B 1 346 ? -14.43121 21.71580  -61.32003 1.000 57.61137 ? 346 ARG   B NE  1 
ATOM   4678 C  CZ  . ARG   B 1 346 ? -15.54914 21.86003  -60.60788 1.000 66.90722 ? 346 ARG   B CZ  1 
ATOM   4679 N  NH1 . ARG   B 1 346 ? -16.04100 23.07282  -60.37673 1.000 61.71064 ? 346 ARG   B NH1 1 
ATOM   4680 N  NH2 . ARG   B 1 346 ? -16.17986 20.79223  -60.12475 1.000 58.05793 ? 346 ARG   B NH2 1 
ATOM   4681 N  N   . GLU   B 1 347 ? -8.21060  20.74540  -61.89762 1.000 36.86694 ? 347 GLU   B N   1 
ATOM   4682 C  CA  . GLU   B 1 347 ? -7.05188  20.35570  -61.09559 1.000 38.21944 ? 347 GLU   B CA  1 
ATOM   4683 C  C   . GLU   B 1 347 ? -5.89000  21.31059  -61.33198 1.000 52.45226 ? 347 GLU   B C   1 
ATOM   4684 O  O   . GLU   B 1 347 ? -5.14043  21.63185  -60.40078 1.000 51.45365 ? 347 GLU   B O   1 
ATOM   4685 C  CB  . GLU   B 1 347 ? -6.62348  18.92123  -61.42007 1.000 41.08426 ? 347 GLU   B CB  1 
ATOM   4686 C  CG  . GLU   B 1 347 ? -7.65148  17.83476  -61.07967 1.000 39.97114 ? 347 GLU   B CG  1 
ATOM   4687 C  CD  . GLU   B 1 347 ? -7.37042  16.50134  -61.77452 1.000 39.11888 ? 347 GLU   B CD  1 
ATOM   4688 O  OE1 . GLU   B 1 347 ? -6.62679  16.48492  -62.77936 1.000 45.58214 ? 347 GLU   B OE1 1 
ATOM   4689 O  OE2 . GLU   B 1 347 ? -7.89801  15.46678  -61.31662 1.000 31.70385 ? 347 GLU   B OE2 1 
ATOM   4690 N  N   . ARG   B 1 348 ? -5.73730  21.77349  -62.57903 1.000 50.55977 ? 348 ARG   B N   1 
ATOM   4691 C  CA  . ARG   B 1 348 ? -4.66252  22.69373  -62.94521 1.000 49.53306 ? 348 ARG   B CA  1 
ATOM   4692 C  C   . ARG   B 1 348 ? -4.78828  24.02187  -62.20229 1.000 48.21080 ? 348 ARG   B C   1 
ATOM   4693 O  O   . ARG   B 1 348 ? -3.81934  24.50532  -61.60615 1.000 49.71343 ? 348 ARG   B O   1 
ATOM   4694 C  CB  . ARG   B 1 348 ? -4.68504  22.90791  -64.45965 1.000 47.37375 ? 348 ARG   B CB  1 
ATOM   4695 C  CG  . ARG   B 1 348 ? -3.49894  23.63023  -65.04688 1.000 50.65706 ? 348 ARG   B CG  1 
ATOM   4696 C  CD  . ARG   B 1 348 ? -3.62627  23.68067  -66.56351 1.000 58.21902 ? 348 ARG   B CD  1 
ATOM   4697 N  NE  . ARG   B 1 348 ? -3.78738  22.35035  -67.15365 1.000 55.49849 ? 348 ARG   B NE  1 
ATOM   4698 C  CZ  . ARG   B 1 348 ? -4.85615  21.95764  -67.84375 1.000 50.41359 ? 348 ARG   B CZ  1 
ATOM   4699 N  NH1 . ARG   B 1 348 ? -5.87017  22.79221  -68.03844 1.000 50.81910 ? 348 ARG   B NH1 1 
ATOM   4700 N  NH2 . ARG   B 1 348 ? -4.91396  20.72799  -68.33988 1.000 47.64793 ? 348 ARG   B NH2 1 
ATOM   4701 N  N   . GLU   B 1 349 ? -5.98472  24.62086  -62.22200 1.000 44.65749 ? 349 GLU   B N   1 
ATOM   4702 C  CA  . GLU   B 1 349 ? -6.22346  25.87163  -61.50465 1.000 47.17408 ? 349 GLU   B CA  1 
ATOM   4703 C  C   . GLU   B 1 349 ? -5.82007  25.77909  -60.03833 1.000 52.40623 ? 349 GLU   B C   1 
ATOM   4704 O  O   . GLU   B 1 349 ? -5.32902  26.75399  -59.45792 1.000 62.99517 ? 349 GLU   B O   1 
ATOM   4705 C  CB  . GLU   B 1 349 ? -7.69868  26.25738  -61.59937 1.000 50.73870 ? 349 GLU   B CB  1 
ATOM   4706 C  CG  . GLU   B 1 349 ? -8.08243  27.01558  -62.84544 1.000 51.62977 ? 349 GLU   B CG  1 
ATOM   4707 C  CD  . GLU   B 1 349 ? -9.57632  27.28845  -62.90932 1.000 52.32125 ? 349 GLU   B CD  1 
ATOM   4708 O  OE1 . GLU   B 1 349 ? -10.36097 26.55335  -62.26682 1.000 49.24081 ? 349 GLU   B OE1 1 
ATOM   4709 O  OE2 . GLU   B 1 349 ? -9.96895  28.24341  -63.60583 1.000 60.31864 ? 349 GLU   B OE2 1 
ATOM   4710 N  N   . ARG   B 1 350 ? -6.05031  24.63021  -59.41343 1.000 51.44374 ? 350 ARG   B N   1 
ATOM   4711 C  CA  . ARG   B 1 350 ? -5.72909  24.41895  -58.01049 1.000 53.33502 ? 350 ARG   B CA  1 
ATOM   4712 C  C   . ARG   B 1 350 ? -4.38060  23.75206  -57.83414 1.000 47.12418 ? 350 ARG   B C   1 
ATOM   4713 O  O   . ARG   B 1 350 ? -4.03655  23.34051  -56.72250 1.000 45.54209 ? 350 ARG   B O   1 
ATOM   4714 C  CB  . ARG   B 1 350 ? -6.82540  23.58766  -57.35563 1.000 60.69005 ? 350 ARG   B CB  1 
ATOM   4715 C  CG  . ARG   B 1 350 ? -8.16761  23.84964  -57.99240 1.000 59.55173 ? 350 ARG   B CG  1 
ATOM   4716 C  CD  . ARG   B 1 350 ? -9.20575  22.84710  -57.56691 1.000 63.52729 ? 350 ARG   B CD  1 
ATOM   4717 N  NE  . ARG   B 1 350 ? -10.01989 23.38941  -56.49240 1.000 75.09140 ? 350 ARG   B NE  1 
ATOM   4718 C  CZ  . ARG   B 1 350 ? -9.87715  23.05375  -55.21795 1.000 74.65624 ? 350 ARG   B CZ  1 
ATOM   4719 N  NH1 . ARG   B 1 350 ? -8.95503  22.16820  -54.87504 1.000 72.22343 ? 350 ARG   B NH1 1 
ATOM   4720 N  NH2 . ARG   B 1 350 ? -10.65279 23.59985  -54.29042 1.000 65.94492 ? 350 ARG   B NH2 1 
ATOM   4721 N  N   . GLY   B 1 351 ? -3.61745  23.63149  -58.91085 1.000 51.73458 ? 351 GLY   B N   1 
ATOM   4722 C  CA  . GLY   B 1 351 ? -2.29293  23.06714  -58.83067 1.000 50.45848 ? 351 GLY   B CA  1 
ATOM   4723 C  C   . GLY   B 1 351 ? -2.25187  21.67157  -58.26391 1.000 47.32579 ? 351 GLY   B C   1 
ATOM   4724 O  O   . GLY   B 1 351 ? -1.73286  21.44322  -57.16850 1.000 55.97753 ? 351 GLY   B O   1 
ATOM   4725 N  N   . MET   B 1 352 ? -2.81294  20.73418  -59.00298 1.000 47.89918 ? 352 MET   B N   1 
ATOM   4726 C  CA  . MET   B 1 352 ? -2.79323  19.33628  -58.63186 1.000 48.91693 ? 352 MET   B CA  1 
ATOM   4727 C  C   . MET   B 1 352 ? -2.21982  18.56168  -59.79857 1.000 59.33454 ? 352 MET   B C   1 
ATOM   4728 O  O   . MET   B 1 352 ? -2.47835  18.89863  -60.95916 1.000 56.97525 ? 352 MET   B O   1 
ATOM   4729 C  CB  . MET   B 1 352 ? -4.19267  18.83367  -58.28781 1.000 52.46806 ? 352 MET   B CB  1 
ATOM   4730 C  CG  . MET   B 1 352 ? -4.86424  19.62801  -57.18698 1.000 54.30020 ? 352 MET   B CG  1 
ATOM   4731 S  SD  . MET   B 1 352 ? -6.63961  19.31837  -57.08127 1.000 60.60850 ? 352 MET   B SD  1 
ATOM   4732 C  CE  . MET   B 1 352 ? -6.63290  17.56313  -56.71420 1.000 43.78721 ? 352 MET   B CE  1 
ATOM   4733 N  N   . GLU   B 1 353 ? -1.42004  17.54713  -59.48267 1.000 54.04407 ? 353 GLU   B N   1 
ATOM   4734 C  CA  . GLU   B 1 353 ? -0.88776  16.66370  -60.50912 1.000 66.39060 ? 353 GLU   B CA  1 
ATOM   4735 C  C   . GLU   B 1 353 ? -2.03935  15.97432  -61.23671 1.000 64.28367 ? 353 GLU   B C   1 
ATOM   4736 O  O   . GLU   B 1 353 ? -2.92353  15.38571  -60.60577 1.000 64.48518 ? 353 GLU   B O   1 
ATOM   4737 C  CB  . GLU   B 1 353 ? 0.06490   15.65631  -59.86345 1.000 70.34327 ? 353 GLU   B CB  1 
ATOM   4738 C  CG  . GLU   B 1 353 ? 0.41250   14.45777  -60.69181 1.000 64.91532 ? 353 GLU   B CG  1 
ATOM   4739 C  CD  . GLU   B 1 353 ? -0.38620  13.24301  -60.26646 1.000 64.93994 ? 353 GLU   B CD  1 
ATOM   4740 O  OE1 . GLU   B 1 353 ? -1.22623  13.36138  -59.33678 1.000 62.69850 ? 353 GLU   B OE1 1 
ATOM   4741 O  OE2 . GLU   B 1 353 ? -0.17770  12.15472  -60.84970 1.000 72.57663 ? 353 GLU   B OE2 1 
ATOM   4742 N  N   . ILE   B 1 354 ? -2.03211  16.06443  -62.57012 1.000 60.17901 ? 354 ILE   B N   1 
ATOM   4743 C  CA  . ILE   B 1 354 ? -3.24159  15.81680  -63.35202 1.000 61.06004 ? 354 ILE   B CA  1 
ATOM   4744 C  C   . ILE   B 1 354 ? -3.59150  14.33252  -63.32847 1.000 56.59564 ? 354 ILE   B C   1 
ATOM   4745 O  O   . ILE   B 1 354 ? -2.72669  13.46648  -63.52358 1.000 55.28865 ? 354 ILE   B O   1 
ATOM   4746 C  CB  . ILE   B 1 354 ? -3.07830  16.33898  -64.79151 1.000 57.27458 ? 354 ILE   B CB  1 
ATOM   4747 C  CG1 . ILE   B 1 354 ? -3.24604  17.86620  -64.86827 1.000 49.26725 ? 354 ILE   B CG1 1 
ATOM   4748 C  CG2 . ILE   B 1 354 ? -4.08232  15.67711  -65.72625 1.000 52.40473 ? 354 ILE   B CG2 1 
ATOM   4749 C  CD1 . ILE   B 1 354 ? -2.12168  18.67937  -64.26926 1.000 59.62859 ? 354 ILE   B CD1 1 
ATOM   4750 N  N   . SER   B 1 355 ? -4.86635  14.03561  -63.07540 1.000 47.61900 ? 355 SER   B N   1 
ATOM   4751 C  CA  . SER   B 1 355 ? -5.32601  12.65607  -63.08124 1.000 46.43353 ? 355 SER   B CA  1 
ATOM   4752 C  C   . SER   B 1 355 ? -5.08222  12.04608  -64.45835 1.000 54.61338 ? 355 SER   B C   1 
ATOM   4753 O  O   . SER   B 1 355 ? -5.22575  12.74048  -65.47410 1.000 50.80190 ? 355 SER   B O   1 
ATOM   4754 C  CB  . SER   B 1 355 ? -6.81687  12.58039  -62.73961 1.000 43.17037 ? 355 SER   B CB  1 
ATOM   4755 O  OG  . SER   B 1 355 ? -7.13894  13.41342  -61.63994 1.000 39.51906 ? 355 SER   B OG  1 
ATOM   4756 N  N   . PRO   B 1 356 ? -4.69858  10.75784  -64.53037 1.000 55.86633 ? 356 PRO   B N   1 
ATOM   4757 C  CA  . PRO   B 1 356 ? -4.45991  10.11697  -65.83252 1.000 54.69990 ? 356 PRO   B CA  1 
ATOM   4758 C  C   . PRO   B 1 356 ? -5.51888  10.42508  -66.88714 1.000 61.85191 ? 356 PRO   B C   1 
ATOM   4759 O  O   . PRO   B 1 356 ? -6.72126  10.25716  -66.64775 1.000 57.74325 ? 356 PRO   B O   1 
ATOM   4760 C  CB  . PRO   B 1 356 ? -4.43655  8.61667   -65.48491 1.000 58.61378 ? 356 PRO   B CB  1 
ATOM   4761 C  CG  . PRO   B 1 356 ? -4.73064  8.51665   -63.98132 1.000 53.47268 ? 356 PRO   B CG  1 
ATOM   4762 C  CD  . PRO   B 1 356 ? -4.38579  9.85324   -63.41129 1.000 49.21794 ? 356 PRO   B CD  1 
ATOM   4763 N  N   . MET   B 1 357 ? -5.06208  10.87584  -68.06413 1.000 58.38883 ? 357 MET   B N   1 
ATOM   4764 C  CA  . MET   B 1 357 ? -5.87617  11.14049  -69.25563 1.000 52.40067 ? 357 MET   B CA  1 
ATOM   4765 C  C   . MET   B 1 357 ? -6.82343  12.32911  -69.09419 1.000 51.58801 ? 357 MET   B C   1 
ATOM   4766 O  O   . MET   B 1 357 ? -7.82293  12.42744  -69.81600 1.000 52.48983 ? 357 MET   B O   1 
ATOM   4767 C  CB  . MET   B 1 357 ? -6.66227  9.89480   -69.70564 1.000 55.94600 ? 357 MET   B CB  1 
ATOM   4768 C  CG  . MET   B 1 357 ? -5.97941  8.55854   -69.38978 1.000 68.86131 ? 357 MET   B CG  1 
ATOM   4769 S  SD  . MET   B 1 357 ? -7.07111  7.12963   -69.48561 1.000 91.25308 ? 357 MET   B SD  1 
ATOM   4770 C  CE  . MET   B 1 357 ? -8.06562  7.35159   -67.99973 1.000 89.95488 ? 357 MET   B CE  1 
ATOM   4771 N  N   . CYS   B 1 358 ? -6.51983  13.26249  -68.19115 1.000 52.16879 ? 358 CYS   B N   1 
ATOM   4772 C  CA  . CYS   B 1 358 ? -7.30746  14.48100  -68.02098 1.000 47.17909 ? 358 CYS   B CA  1 
ATOM   4773 C  C   . CYS   B 1 358 ? -6.57214  15.72502  -68.50710 1.000 38.56437 ? 358 CYS   B C   1 
ATOM   4774 O  O   . CYS   B 1 358 ? -7.05026  16.84943  -68.30091 1.000 35.58854 ? 358 CYS   B O   1 
ATOM   4775 C  CB  . CYS   B 1 358 ? -7.71282  14.64053  -66.55551 1.000 37.66248 ? 358 CYS   B CB  1 
ATOM   4776 S  SG  . CYS   B 1 358 ? -9.03649  13.52481  -66.06738 1.000 37.88520 ? 358 CYS   B SG  1 
ATOM   4777 N  N   . ASP   B 1 359 ? -5.43530  15.53971  -69.16131 1.000 39.76112 ? 359 ASP   B N   1 
ATOM   4778 C  CA  . ASP   B 1 359 ? -4.53879  16.61559  -69.57141 1.000 46.66538 ? 359 ASP   B CA  1 
ATOM   4779 C  C   . ASP   B 1 359 ? -4.78919  16.88870  -71.05461 1.000 40.77818 ? 359 ASP   B C   1 
ATOM   4780 O  O   . ASP   B 1 359 ? -4.34157  16.12525  -71.91546 1.000 40.14654 ? 359 ASP   B O   1 
ATOM   4781 C  CB  . ASP   B 1 359 ? -3.09671  16.18941  -69.29964 1.000 48.43761 ? 359 ASP   B CB  1 
ATOM   4782 C  CG  . ASP   B 1 359 ? -2.09482  17.30634  -69.48976 1.000 41.60110 ? 359 ASP   B CG  1 
ATOM   4783 O  OD1 . ASP   B 1 359 ? -2.41960  18.32430  -70.12721 1.000 43.61625 ? 359 ASP   B OD1 1 
ATOM   4784 O  OD2 . ASP   B 1 359 ? -0.96015  17.14530  -69.00352 1.000 47.84264 ? 359 ASP   B OD2 1 
ATOM   4785 N  N   . LYS   B 1 360 ? -5.50217  17.98401  -71.35623 1.000 36.96087 ? 360 LYS   B N   1 
ATOM   4786 C  CA  . LYS   B 1 360 ? -5.81696  18.29468  -72.75135 1.000 42.65136 ? 360 LYS   B CA  1 
ATOM   4787 C  C   . LYS   B 1 360 ? -4.55585  18.47721  -73.58858 1.000 53.14623 ? 360 LYS   B C   1 
ATOM   4788 O  O   . LYS   B 1 360 ? -4.57732  18.23153  -74.80161 1.000 51.69560 ? 360 LYS   B O   1 
ATOM   4789 C  CB  . LYS   B 1 360 ? -6.70562  19.54494  -72.84382 1.000 45.90561 ? 360 LYS   B CB  1 
ATOM   4790 C  CG  . LYS   B 1 360 ? -6.08900  20.84014  -72.30389 1.000 45.12317 ? 360 LYS   B CG  1 
ATOM   4791 C  CD  . LYS   B 1 360 ? -7.14023  21.94765  -72.11722 1.000 37.37895 ? 360 LYS   B CD  1 
ATOM   4792 C  CE  . LYS   B 1 360 ? -6.47913  23.25347  -71.66496 1.000 37.24368 ? 360 LYS   B CE  1 
ATOM   4793 N  NZ  . LYS   B 1 360 ? -7.42495  24.29599  -71.16212 1.000 34.94323 ? 360 LYS   B NZ  1 
ATOM   4794 N  N   . HIS   B 1 361 ? -3.44321  18.86028  -72.95770 1.000 43.88615 ? 361 HIS   B N   1 
ATOM   4795 C  CA  . HIS   B 1 361 ? -2.22464  19.19473  -73.67668 1.000 48.59182 ? 361 HIS   B CA  1 
ATOM   4796 C  C   . HIS   B 1 361 ? -1.28921  18.01227  -73.90156 1.000 52.07872 ? 361 HIS   B C   1 
ATOM   4797 O  O   . HIS   B 1 361 ? -0.29064  18.17020  -74.61257 1.000 62.95914 ? 361 HIS   B O   1 
ATOM   4798 C  CB  . HIS   B 1 361 ? -1.48083  20.30638  -72.93524 1.000 51.06879 ? 361 HIS   B CB  1 
ATOM   4799 C  CG  . HIS   B 1 361 ? -2.25479  21.58058  -72.85187 1.000 44.55947 ? 361 HIS   B CG  1 
ATOM   4800 N  ND1 . HIS   B 1 361 ? -2.83270  22.16731  -73.95645 1.000 50.57673 ? 361 HIS   B ND1 1 
ATOM   4801 C  CD2 . HIS   B 1 361 ? -2.56238  22.37267  -71.79889 1.000 43.48586 ? 361 HIS   B CD2 1 
ATOM   4802 C  CE1 . HIS   B 1 361 ? -3.45677  23.27209  -73.58961 1.000 48.07143 ? 361 HIS   B CE1 1 
ATOM   4803 N  NE2 . HIS   B 1 361 ? -3.30632  23.42040  -72.28549 1.000 49.62344 ? 361 HIS   B NE2 1 
ATOM   4804 N  N   . ASN   B 1 362 ? -1.56562  16.84316  -73.32961 1.000 48.82596 ? 362 ASN   B N   1 
ATOM   4805 C  CA  . ASN   B 1 362 ? -0.78436  15.64573  -73.64335 1.000 50.78862 ? 362 ASN   B CA  1 
ATOM   4806 C  C   . ASN   B 1 362 ? -1.68294  14.41346  -73.64182 1.000 52.18973 ? 362 ASN   B C   1 
ATOM   4807 O  O   . ASN   B 1 362 ? -1.37679  13.38874  -73.03074 1.000 54.27151 ? 362 ASN   B O   1 
ATOM   4808 C  CB  . ASN   B 1 362 ? 0.39303   15.48088  -72.68424 1.000 56.53404 ? 362 ASN   B CB  1 
ATOM   4809 C  CG  . ASN   B 1 362 ? 1.62033   16.26533  -73.13245 1.000 66.78776 ? 362 ASN   B CG  1 
ATOM   4810 O  OD1 . ASN   B 1 362 ? 1.75288   17.45459  -72.83666 1.000 67.53287 ? 362 ASN   B OD1 1 
ATOM   4811 N  ND2 . ASN   B 1 362 ? 2.51835   15.60235  -73.86095 1.000 66.13757 ? 362 ASN   B ND2 1 
ATOM   4812 N  N   . ALA   B 1 363 ? -2.79509  14.49502  -74.37038 1.000 49.07525 ? 363 ALA   B N   1 
ATOM   4813 C  CA  . ALA   B 1 363 ? -3.81218  13.44930  -74.39543 1.000 47.15164 ? 363 ALA   B CA  1 
ATOM   4814 C  C   . ALA   B 1 363 ? -3.81366  12.72831  -75.73780 1.000 41.28663 ? 363 ALA   B C   1 
ATOM   4815 O  O   . ALA   B 1 363 ? -3.83948  13.36845  -76.79487 1.000 39.46468 ? 363 ALA   B O   1 
ATOM   4816 C  CB  . ALA   B 1 363 ? -5.20039  14.03616  -74.12466 1.000 37.98816 ? 363 ALA   B CB  1 
ATOM   4817 N  N   . SER   B 1 364 ? -3.81170  11.40289  -75.69492 1.000 33.79509 ? 364 SER   B N   1 
ATOM   4818 C  CA  . SER   B 1 364 ? -3.97696  10.57504  -76.88987 1.000 34.61121 ? 364 SER   B CA  1 
ATOM   4819 C  C   . SER   B 1 364 ? -5.33282  9.89454   -76.74903 1.000 23.99923 ? 364 SER   B C   1 
ATOM   4820 O  O   . SER   B 1 364 ? -5.43966  8.80248   -76.19012 1.000 27.75440 ? 364 SER   B O   1 
ATOM   4821 C  CB  . SER   B 1 364 ? -2.85249  9.56587   -77.01985 1.000 38.32779 ? 364 SER   B CB  1 
ATOM   4822 O  OG  . SER   B 1 364 ? -1.64000  10.12057  -76.53246 1.000 46.53956 ? 364 SER   B OG  1 
ATOM   4823 N  N   . VAL   B 1 365 ? -6.37072  10.56430  -77.24375 1.000 17.98079 ? 365 VAL   B N   1 
ATOM   4824 C  CA  . VAL   B 1 365 ? -7.74139  10.11244  -77.01824 1.000 25.92664 ? 365 VAL   B CA  1 
ATOM   4825 C  C   . VAL   B 1 365 ? -7.95031  8.70935   -77.56990 1.000 24.57399 ? 365 VAL   B C   1 
ATOM   4826 O  O   . VAL   B 1 365 ? -8.61270  7.86635   -76.94811 1.000 25.17688 ? 365 VAL   B O   1 
ATOM   4827 C  CB  . VAL   B 1 365 ? -8.73314  11.11043  -77.64376 1.000 22.55029 ? 365 VAL   B CB  1 
ATOM   4828 C  CG1 . VAL   B 1 365 ? -10.10137 10.45998  -77.80696 1.000 17.38839 ? 365 VAL   B CG1 1 
ATOM   4829 C  CG2 . VAL   B 1 365 ? -8.80979  12.37615  -76.80263 1.000 21.02580 ? 365 VAL   B CG2 1 
ATOM   4830 N  N   . GLU   B 1 366 ? -7.39819  8.43842   -78.74408 1.000 21.84677 ? 366 GLU   B N   1 
ATOM   4831 C  CA  . GLU   B 1 366 ? -7.65440  7.16245   -79.39499 1.000 18.73886 ? 366 GLU   B CA  1 
ATOM   4832 C  C   . GLU   B 1 366 ? -6.87147  6.03909   -78.72363 1.000 24.26355 ? 366 GLU   B C   1 
ATOM   4833 O  O   . GLU   B 1 366 ? -7.43552  4.98177   -78.41038 1.000 21.39859 ? 366 GLU   B O   1 
ATOM   4834 C  CB  . GLU   B 1 366 ? -7.32407  7.27617   -80.87891 1.000 17.03570 ? 366 GLU   B CB  1 
ATOM   4835 C  CG  . GLU   B 1 366 ? -8.19966  8.31274   -81.62102 1.000 19.17145 ? 366 GLU   B CG  1 
ATOM   4836 C  CD  . GLU   B 1 366 ? -7.74312  9.76217   -81.40291 1.000 21.51216 ? 366 GLU   B CD  1 
ATOM   4837 O  OE1 . GLU   B 1 366 ? -8.58000  10.68918  -81.52308 1.000 16.90879 ? 366 GLU   B OE1 1 
ATOM   4838 O  OE2 . GLU   B 1 366 ? -6.54703  9.95866   -81.10090 1.000 21.71563 ? 366 GLU   B OE2 1 
ATOM   4839 N  N   . LYS   B 1 367 ? -5.57531  6.25932   -78.48085 1.000 21.05286 ? 367 LYS   B N   1 
ATOM   4840 C  CA  . LYS   B 1 367 ? -4.79334  5.31165   -77.70008 1.000 23.12112 ? 367 LYS   B CA  1 
ATOM   4841 C  C   . LYS   B 1 367 ? -5.51447  4.94802   -76.40258 1.000 23.70737 ? 367 LYS   B C   1 
ATOM   4842 O  O   . LYS   B 1 367 ? -5.60948  3.77124   -76.03574 1.000 24.06805 ? 367 LYS   B O   1 
ATOM   4843 C  CB  . LYS   B 1 367 ? -3.41800  5.91209   -77.40987 1.000 30.04759 ? 367 LYS   B CB  1 
ATOM   4844 C  CG  . LYS   B 1 367 ? -2.26817  4.92089   -77.41698 1.000 31.61069 ? 367 LYS   B CG  1 
ATOM   4845 C  CD  . LYS   B 1 367 ? -0.93392  5.62933   -77.65782 1.000 38.40232 ? 367 LYS   B CD  1 
ATOM   4846 C  CE  . LYS   B 1 367 ? -0.13669  4.91919   -78.75571 1.000 48.28756 ? 367 LYS   B CE  1 
ATOM   4847 N  NZ  . LYS   B 1 367 ? 1.19947   5.52392   -79.01730 1.000 41.59057 ? 367 LYS   B NZ  1 
ATOM   4848 N  N   . SER   B 1 368 ? -6.08574  5.94408   -75.73025 1.000 19.74043 ? 368 SER   B N   1 
ATOM   4849 C  CA  . SER   B 1 368 ? -6.73371  5.69795   -74.45183 1.000 22.54556 ? 368 SER   B CA  1 
ATOM   4850 C  C   . SER   B 1 368 ? -7.98172  4.82895   -74.60597 1.000 25.54057 ? 368 SER   B C   1 
ATOM   4851 O  O   . SER   B 1 368 ? -8.25408  3.97813   -73.75292 1.000 22.39685 ? 368 SER   B O   1 
ATOM   4852 C  CB  . SER   B 1 368 ? -7.06289  7.02651   -73.78871 1.000 23.61829 ? 368 SER   B CB  1 
ATOM   4853 O  OG  . SER   B 1 368 ? -5.86298  7.68099   -73.44395 1.000 41.11157 ? 368 SER   B OG  1 
ATOM   4854 N  N   . GLN   B 1 369 ? -8.74382  5.01328   -75.68835 1.000 21.27384 ? 369 GLN   B N   1 
ATOM   4855 C  CA  . GLN   B 1 369 ? -9.90687  4.16003   -75.91648 1.000 23.32868 ? 369 GLN   B CA  1 
ATOM   4856 C  C   . GLN   B 1 369 ? -9.49705  2.70464   -76.14036 1.000 24.22247 ? 369 GLN   B C   1 
ATOM   4857 O  O   . GLN   B 1 369 ? -10.13708 1.78743   -75.61856 1.000 20.52603 ? 369 GLN   B O   1 
ATOM   4858 C  CB  . GLN   B 1 369 ? -10.71903 4.68662   -77.09741 1.000 20.58023 ? 369 GLN   B CB  1 
ATOM   4859 C  CG  . GLN   B 1 369 ? -11.53049 5.90054   -76.74509 1.000 17.21105 ? 369 GLN   B CG  1 
ATOM   4860 C  CD  . GLN   B 1 369 ? -12.38612 5.66621   -75.50803 1.000 25.34787 ? 369 GLN   B CD  1 
ATOM   4861 O  OE1 . GLN   B 1 369 ? -13.23488 4.76848   -75.48143 1.000 22.29027 ? 369 GLN   B OE1 1 
ATOM   4862 N  NE2 . GLN   B 1 369 ? -12.15099 6.45825   -74.46819 1.000 22.12009 ? 369 GLN   B NE2 1 
ATOM   4863 N  N   . VAL   B 1 370 ? -8.41327  2.48183   -76.88761 1.000 22.21086 ? 370 VAL   B N   1 
ATOM   4864 C  CA  . VAL   B 1 370 ? -7.92151  1.13094   -77.13739 1.000 20.67167 ? 370 VAL   B CA  1 
ATOM   4865 C  C   . VAL   B 1 370 ? -7.45204  0.47702   -75.83656 1.000 26.47728 ? 370 VAL   B C   1 
ATOM   4866 O  O   . VAL   B 1 370 ? -7.75541  -0.69081  -75.56240 1.000 23.71117 ? 370 VAL   B O   1 
ATOM   4867 C  CB  . VAL   B 1 370 ? -6.80536  1.17258   -78.19686 1.000 21.04477 ? 370 VAL   B CB  1 
ATOM   4868 C  CG1 . VAL   B 1 370 ? -6.13803  -0.19037  -78.34396 1.000 16.43205 ? 370 VAL   B CG1 1 
ATOM   4869 C  CG2 . VAL   B 1 370 ? -7.38289  1.64319   -79.53426 1.000 21.15761 ? 370 VAL   B CG2 1 
ATOM   4870 N  N   . GLY   B 1 371 ? -6.67966  1.21042   -75.02840 1.000 27.08134 ? 371 GLY   B N   1 
ATOM   4871 C  CA  . GLY   B 1 371 ? -6.31885  0.70467   -73.71156 1.000 21.05052 ? 371 GLY   B CA  1 
ATOM   4872 C  C   . GLY   B 1 371 ? -7.53723  0.45521   -72.83974 1.000 30.91377 ? 371 GLY   B C   1 
ATOM   4873 O  O   . GLY   B 1 371 ? -7.65369  -0.59765  -72.20111 1.000 35.10244 ? 371 GLY   B O   1 
ATOM   4874 N  N   . PHE   B 1 372 ? -8.47023  1.41359   -72.81651 1.000 22.38741 ? 372 PHE   B N   1 
ATOM   4875 C  CA  . PHE   B 1 372 ? -9.70103  1.25610   -72.04747 1.000 22.92876 ? 372 PHE   B CA  1 
ATOM   4876 C  C   . PHE   B 1 372 ? -10.43144 -0.02880  -72.43207 1.000 28.74354 ? 372 PHE   B C   1 
ATOM   4877 O  O   . PHE   B 1 372 ? -10.89889 -0.77677  -71.56179 1.000 22.05042 ? 372 PHE   B O   1 
ATOM   4878 C  CB  . PHE   B 1 372 ? -10.58382 2.48156   -72.27470 1.000 27.34178 ? 372 PHE   B CB  1 
ATOM   4879 C  CG  . PHE   B 1 372 ? -11.87225 2.48715   -71.48542 1.000 30.98995 ? 372 PHE   B CG  1 
ATOM   4880 C  CD1 . PHE   B 1 372 ? -11.88710 2.18339   -70.13323 1.000 26.18101 ? 372 PHE   B CD1 1 
ATOM   4881 C  CD2 . PHE   B 1 372 ? -13.06442 2.84389   -72.09986 1.000 30.34938 ? 372 PHE   B CD2 1 
ATOM   4882 C  CE1 . PHE   B 1 372 ? -13.07064 2.21576   -69.41172 1.000 31.19711 ? 372 PHE   B CE1 1 
ATOM   4883 C  CE2 . PHE   B 1 372 ? -14.25751 2.87663   -71.38225 1.000 30.38231 ? 372 PHE   B CE2 1 
ATOM   4884 C  CZ  . PHE   B 1 372 ? -14.25840 2.56446   -70.03928 1.000 25.95432 ? 372 PHE   B CZ  1 
ATOM   4885 N  N   . ILE   B 1 373 ? -10.52118 -0.29975  -73.73735 1.000 23.72280 ? 373 ILE   B N   1 
ATOM   4886 C  CA  . ILE   B 1 373 ? -11.13952 -1.52306  -74.23723 1.000 26.35291 ? 373 ILE   B CA  1 
ATOM   4887 C  C   . ILE   B 1 373 ? -10.29101 -2.73638  -73.88119 1.000 21.26865 ? 373 ILE   B C   1 
ATOM   4888 O  O   . ILE   B 1 373 ? -10.79766 -3.73967  -73.37092 1.000 27.00872 ? 373 ILE   B O   1 
ATOM   4889 C  CB  . ILE   B 1 373 ? -11.35179 -1.42444  -75.76161 1.000 29.54439 ? 373 ILE   B CB  1 
ATOM   4890 C  CG1 . ILE   B 1 373 ? -12.50812 -0.47552  -76.08022 1.000 19.69055 ? 373 ILE   B CG1 1 
ATOM   4891 C  CG2 . ILE   B 1 373 ? -11.56140 -2.80760  -76.36547 1.000 25.39920 ? 373 ILE   B CG2 1 
ATOM   4892 C  CD1 . ILE   B 1 373 ? -12.75244 -0.29342  -77.56495 1.000 22.26136 ? 373 ILE   B CD1 1 
ATOM   4893 N  N   . ASP   B 1 374 ? -8.99474  -2.66617  -74.15623 1.000 23.78192 ? 374 ASP   B N   1 
ATOM   4894 C  CA  . ASP   B 1 374 ? -8.12768  -3.81029  -73.90990 1.000 27.97051 ? 374 ASP   B CA  1 
ATOM   4895 C  C   . ASP   B 1 374 ? -8.11515  -4.19680  -72.43540 1.000 36.12791 ? 374 ASP   B C   1 
ATOM   4896 O  O   . ASP   B 1 374 ? -8.17406  -5.38595  -72.10330 1.000 33.44815 ? 374 ASP   B O   1 
ATOM   4897 C  CB  . ASP   B 1 374 ? -6.70497  -3.51072  -74.37041 1.000 25.80666 ? 374 ASP   B CB  1 
ATOM   4898 C  CG  . ASP   B 1 374 ? -6.55520  -3.50640  -75.87947 1.000 26.22913 ? 374 ASP   B CG  1 
ATOM   4899 O  OD1 . ASP   B 1 374 ? -7.55392  -3.69884  -76.59644 1.000 24.22224 ? 374 ASP   B OD1 1 
ATOM   4900 O  OD2 . ASP   B 1 374 ? -5.41599  -3.28792  -76.34841 1.000 27.50761 ? 374 ASP   B OD2 1 
ATOM   4901 N  N   . TYR   B 1 375 ? -8.03881  -3.20856  -71.53440 1.000 33.18239 ? 375 TYR   B N   1 
ATOM   4902 C  CA  . TYR   B 1 375 ? -7.73423  -3.48692  -70.13388 1.000 32.56157 ? 375 TYR   B CA  1 
ATOM   4903 C  C   . TYR   B 1 375 ? -8.94382  -3.46531  -69.20918 1.000 33.32224 ? 375 TYR   B C   1 
ATOM   4904 O  O   . TYR   B 1 375 ? -8.84963  -4.00117  -68.09954 1.000 37.18826 ? 375 TYR   B O   1 
ATOM   4905 C  CB  . TYR   B 1 375 ? -6.67752  -2.50290  -69.61239 1.000 29.35053 ? 375 TYR   B CB  1 
ATOM   4906 C  CG  . TYR   B 1 375 ? -5.28255  -2.91766  -70.00960 1.000 43.55932 ? 375 TYR   B CG  1 
ATOM   4907 C  CD1 . TYR   B 1 375 ? -4.54836  -3.78751  -69.21534 1.000 44.42882 ? 375 TYR   B CD1 1 
ATOM   4908 C  CD2 . TYR   B 1 375 ? -4.71104  -2.47477  -71.19672 1.000 42.63855 ? 375 TYR   B CD2 1 
ATOM   4909 C  CE1 . TYR   B 1 375 ? -3.28080  -4.18639  -69.57792 1.000 47.90334 ? 375 TYR   B CE1 1 
ATOM   4910 C  CE2 . TYR   B 1 375 ? -3.44707  -2.87564  -71.56975 1.000 41.28665 ? 375 TYR   B CE2 1 
ATOM   4911 C  CZ  . TYR   B 1 375 ? -2.73568  -3.73060  -70.75501 1.000 51.04999 ? 375 TYR   B CZ  1 
ATOM   4912 O  OH  . TYR   B 1 375 ? -1.46893  -4.13981  -71.11195 1.000 61.12227 ? 375 TYR   B OH  1 
ATOM   4913 N  N   . ILE   B 1 376 ? -10.07225 -2.89269  -69.63265 1.000 28.75629 ? 376 ILE   B N   1 
ATOM   4914 C  CA  . ILE   B 1 376 ? -11.26155 -2.81905  -68.79365 1.000 17.87065 ? 376 ILE   B CA  1 
ATOM   4915 C  C   . ILE   B 1 376 ? -12.47754 -3.37367  -69.52273 1.000 24.54030 ? 376 ILE   B C   1 
ATOM   4916 O  O   . ILE   B 1 376 ? -13.11998 -4.31380  -69.04513 1.000 27.12969 ? 376 ILE   B O   1 
ATOM   4917 C  CB  . ILE   B 1 376 ? -11.53651 -1.37478  -68.33388 1.000 17.86116 ? 376 ILE   B CB  1 
ATOM   4918 C  CG1 . ILE   B 1 376 ? -10.35630 -0.81166  -67.54749 1.000 28.80261 ? 376 ILE   B CG1 1 
ATOM   4919 C  CG2 . ILE   B 1 376 ? -12.78894 -1.31263  -67.48672 1.000 15.13208 ? 376 ILE   B CG2 1 
ATOM   4920 C  CD1 . ILE   B 1 376 ? -10.20607 -1.40315  -66.15381 1.000 31.69820 ? 376 ILE   B CD1 1 
ATOM   4921 N  N   . VAL   B 1 377 ? -12.82024 -2.78506  -70.67208 1.000 27.56236 ? 377 VAL   B N   1 
ATOM   4922 C  CA  . VAL   B 1 377 ? -14.13692 -3.02102  -71.26603 1.000 19.02848 ? 377 VAL   B CA  1 
ATOM   4923 C  C   . VAL   B 1 377 ? -14.23602 -4.42010  -71.86400 1.000 32.36858 ? 377 VAL   B C   1 
ATOM   4924 O  O   . VAL   B 1 377 ? -15.26170 -5.10291  -71.70817 1.000 25.76743 ? 377 VAL   B O   1 
ATOM   4925 C  CB  . VAL   B 1 377 ? -14.45329 -1.95297  -72.31918 1.000 19.07441 ? 377 VAL   B CB  1 
ATOM   4926 C  CG1 . VAL   B 1 377 ? -15.76803 -2.26807  -72.97655 1.000 16.35081 ? 377 VAL   B CG1 1 
ATOM   4927 C  CG2 . VAL   B 1 377 ? -14.49764 -0.56355  -71.68394 1.000 24.84413 ? 377 VAL   B CG2 1 
ATOM   4928 N  N   . HIS   B 1 378 ? -13.19510 -4.86013  -72.59279 1.000 30.55788 ? 378 HIS   B N   1 
ATOM   4929 C  CA  . HIS   B 1 378 ? -13.27187 -6.18166  -73.21433 1.000 33.25206 ? 378 HIS   B CA  1 
ATOM   4930 C  C   . HIS   B 1 378 ? -13.20069 -7.30097  -72.18138 1.000 36.28867 ? 378 HIS   B C   1 
ATOM   4931 O  O   . HIS   B 1 378 ? -14.04340 -8.21560  -72.24447 1.000 30.99881 ? 378 HIS   B O   1 
ATOM   4932 C  CB  . HIS   B 1 378 ? -12.19806 -6.32976  -74.29796 1.000 33.52079 ? 378 HIS   B CB  1 
ATOM   4933 C  CG  . HIS   B 1 378 ? -12.46315 -7.45380  -75.25873 1.000 35.36579 ? 378 HIS   B CG  1 
ATOM   4934 N  ND1 . HIS   B 1 378 ? -11.90563 -8.70641  -75.11518 1.000 35.05267 ? 378 HIS   B ND1 1 
ATOM   4935 C  CD2 . HIS   B 1 378 ? -13.23690 -7.51380  -76.36964 1.000 41.20195 ? 378 HIS   B CD2 1 
ATOM   4936 C  CE1 . HIS   B 1 378 ? -12.31915 -9.48711  -76.09780 1.000 36.70793 ? 378 HIS   B CE1 1 
ATOM   4937 N  NE2 . HIS   B 1 378 ? -13.13223 -8.78962  -76.87088 1.000 39.20553 ? 378 HIS   B NE2 1 
ATOM   4938 N  N   . PRO   B 1 379 ? -12.25264 -7.30648  -71.21750 1.000 34.95559 ? 379 PRO   B N   1 
ATOM   4939 C  CA  . PRO   B 1 379 ? -12.30021 -8.33383  -70.16043 1.000 29.06924 ? 379 PRO   B CA  1 
ATOM   4940 C  C   . PRO   B 1 379 ? -13.67902 -8.51685  -69.56850 1.000 32.77239 ? 379 PRO   B C   1 
ATOM   4941 O  O   . PRO   B 1 379 ? -14.12143 -9.64848  -69.33559 1.000 34.79847 ? 379 PRO   B O   1 
ATOM   4942 C  CB  . PRO   B 1 379 ? -11.31239 -7.79247  -69.13000 1.000 31.22543 ? 379 PRO   B CB  1 
ATOM   4943 C  CG  . PRO   B 1 379 ? -10.31715 -7.06276  -69.95293 1.000 29.62912 ? 379 PRO   B CG  1 
ATOM   4944 C  CD  . PRO   B 1 379 ? -11.11843 -6.38284  -71.00560 1.000 26.57506 ? 379 PRO   B CD  1 
ATOM   4945 N  N   . LEU   B 1 380 ? -14.39244 -7.41178  -69.37868 1.000 29.58786 ? 380 LEU   B N   1 
ATOM   4946 C  CA  . LEU   B 1 380 ? -15.69399 -7.44699  -68.73113 1.000 28.50279 ? 380 LEU   B CA  1 
ATOM   4947 C  C   . LEU   B 1 380 ? -16.75568 -8.03615  -69.65008 1.000 36.62934 ? 380 LEU   B C   1 
ATOM   4948 O  O   . LEU   B 1 380 ? -17.58689 -8.85839  -69.23205 1.000 34.37634 ? 380 LEU   B O   1 
ATOM   4949 C  CB  . LEU   B 1 380 ? -16.06083 -6.02859  -68.32465 1.000 28.76923 ? 380 LEU   B CB  1 
ATOM   4950 C  CG  . LEU   B 1 380 ? -17.35177 -5.83826  -67.57519 1.000 28.58353 ? 380 LEU   B CG  1 
ATOM   4951 C  CD1 . LEU   B 1 380 ? -17.33554 -6.71533  -66.30315 1.000 26.87233 ? 380 LEU   B CD1 1 
ATOM   4952 C  CD2 . LEU   B 1 380 ? -17.56403 -4.35329  -67.27073 1.000 22.22360 ? 380 LEU   B CD2 1 
ATOM   4953 N  N   . TRP   B 1 381 ? -16.77259 -7.58998  -70.90195 1.000 35.15396 ? 381 TRP   B N   1 
ATOM   4954 C  CA  . TRP   B 1 381 ? -17.75415 -8.08187  -71.85160 1.000 34.32143 ? 381 TRP   B CA  1 
ATOM   4955 C  C   . TRP   B 1 381 ? -17.38940 -9.45454  -72.40197 1.000 35.08224 ? 381 TRP   B C   1 
ATOM   4956 O  O   . TRP   B 1 381 ? -18.26048 -10.15143 -72.92801 1.000 37.82837 ? 381 TRP   B O   1 
ATOM   4957 C  CB  . TRP   B 1 381 ? -17.91696 -7.06522  -72.96619 1.000 27.01950 ? 381 TRP   B CB  1 
ATOM   4958 C  CG  . TRP   B 1 381 ? -18.76401 -5.95191  -72.54422 1.000 27.52833 ? 381 TRP   B CG  1 
ATOM   4959 C  CD1 . TRP   B 1 381 ? -18.35126 -4.72671  -72.12255 1.000 26.40745 ? 381 TRP   B CD1 1 
ATOM   4960 C  CD2 . TRP   B 1 381 ? -20.19469 -5.95200  -72.45727 1.000 24.46784 ? 381 TRP   B CD2 1 
ATOM   4961 N  NE1 . TRP   B 1 381 ? -19.43653 -3.95975  -71.80058 1.000 21.40220 ? 381 TRP   B NE1 1 
ATOM   4962 C  CE2 . TRP   B 1 381 ? -20.57977 -4.69236  -71.99211 1.000 19.48871 ? 381 TRP   B CE2 1 
ATOM   4963 C  CE3 . TRP   B 1 381 ? -21.18297 -6.89815  -72.73439 1.000 25.72153 ? 381 TRP   B CE3 1 
ATOM   4964 C  CZ2 . TRP   B 1 381 ? -21.91831 -4.33818  -71.81307 1.000 25.83373 ? 381 TRP   B CZ2 1 
ATOM   4965 C  CZ3 . TRP   B 1 381 ? -22.50324 -6.55250  -72.54681 1.000 27.72928 ? 381 TRP   B CZ3 1 
ATOM   4966 C  CH2 . TRP   B 1 381 ? -22.86181 -5.28340  -72.08962 1.000 26.39760 ? 381 TRP   B CH2 1 
ATOM   4967 N  N   . GLU   B 1 382 ? -16.12420 -9.84868  -72.29028 1.000 37.74716 ? 382 GLU   B N   1 
ATOM   4968 C  CA  . GLU   B 1 382 ? -15.74522 -11.23016 -72.54438 1.000 36.17278 ? 382 GLU   B CA  1 
ATOM   4969 C  C   . GLU   B 1 382 ? -16.33249 -12.15012 -71.48259 1.000 46.07266 ? 382 GLU   B C   1 
ATOM   4970 O  O   . GLU   B 1 382 ? -17.00040 -13.14232 -71.80327 1.000 47.94689 ? 382 GLU   B O   1 
ATOM   4971 C  CB  . GLU   B 1 382 ? -14.22598 -11.34587 -72.56839 1.000 37.49286 ? 382 GLU   B CB  1 
ATOM   4972 C  CG  . GLU   B 1 382 ? -13.72720 -12.67319 -73.04156 1.000 47.37196 ? 382 GLU   B CG  1 
ATOM   4973 C  CD  . GLU   B 1 382 ? -12.59266 -12.52441 -74.02172 1.000 54.73035 ? 382 GLU   B CD  1 
ATOM   4974 O  OE1 . GLU   B 1 382 ? -12.58949 -13.25173 -75.04516 1.000 64.73247 ? 382 GLU   B OE1 1 
ATOM   4975 O  OE2 . GLU   B 1 382 ? -11.70210 -11.66986 -73.78588 1.000 60.72673 ? 382 GLU   B OE2 1 
ATOM   4976 N  N   . THR   B 1 383 ? -16.11524 -11.81427 -70.20339 1.000 45.48167 ? 383 THR   B N   1 
ATOM   4977 C  CA  . THR   B 1 383 ? -16.60526 -12.65866 -69.12029 1.000 37.75361 ? 383 THR   B CA  1 
ATOM   4978 C  C   . THR   B 1 383 ? -18.12931 -12.70678 -69.10768 1.000 37.26278 ? 383 THR   B C   1 
ATOM   4979 O  O   . THR   B 1 383 ? -18.72291 -13.77294 -68.91401 1.000 48.52503 ? 383 THR   B O   1 
ATOM   4980 C  CB  . THR   B 1 383 ? -16.05659 -12.17316 -67.77637 1.000 34.11128 ? 383 THR   B CB  1 
ATOM   4981 O  OG1 . THR   B 1 383 ? -14.61768 -12.13002 -67.81916 1.000 25.17015 ? 383 THR   B OG1 1 
ATOM   4982 C  CG2 . THR   B 1 383 ? -16.49364 -13.12222 -66.66322 1.000 30.18965 ? 383 THR   B CG2 1 
ATOM   4983 N  N   . TRP   B 1 384 ? -18.78345 -11.57611 -69.35032 1.000 34.10259 ? 384 TRP   B N   1 
ATOM   4984 C  CA  . TRP   B 1 384 ? -20.24044 -11.58532 -69.40312 1.000 35.32416 ? 384 TRP   B CA  1 
ATOM   4985 C  C   . TRP   B 1 384 ? -20.77097 -12.33470 -70.61709 1.000 44.95757 ? 384 TRP   B C   1 
ATOM   4986 O  O   . TRP   B 1 384 ? -21.89283 -12.85932 -70.57244 1.000 43.51943 ? 384 TRP   B O   1 
ATOM   4987 C  CB  . TRP   B 1 384 ? -20.76831 -10.16206 -69.41135 1.000 31.74405 ? 384 TRP   B CB  1 
ATOM   4988 C  CG  . TRP   B 1 384 ? -22.25029 -10.04418 -69.53201 1.000 28.79528 ? 384 TRP   B CG  1 
ATOM   4989 C  CD1 . TRP   B 1 384 ? -22.97672 -9.91958  -70.68068 1.000 35.15016 ? 384 TRP   B CD1 1 
ATOM   4990 C  CD2 . TRP   B 1 384 ? -23.19138 -9.99070  -68.45585 1.000 35.76321 ? 384 TRP   B CD2 1 
ATOM   4991 N  NE1 . TRP   B 1 384 ? -24.31499 -9.78879  -70.38540 1.000 32.02240 ? 384 TRP   B NE1 1 
ATOM   4992 C  CE2 . TRP   B 1 384 ? -24.47241 -9.83226  -69.02593 1.000 30.67982 ? 384 TRP   B CE2 1 
ATOM   4993 C  CE3 . TRP   B 1 384 ? -23.07519 -10.05880 -67.06515 1.000 28.36513 ? 384 TRP   B CE3 1 
ATOM   4994 C  CZ2 . TRP   B 1 384 ? -25.62833 -9.74874  -68.25410 1.000 34.62488 ? 384 TRP   B CZ2 1 
ATOM   4995 C  CZ3 . TRP   B 1 384 ? -24.22464 -9.97788  -66.30528 1.000 33.83707 ? 384 TRP   B CZ3 1 
ATOM   4996 C  CH2 . TRP   B 1 384 ? -25.48321 -9.82894  -66.90081 1.000 30.98434 ? 384 TRP   B CH2 1 
ATOM   4997 N  N   . ALA   B 1 385 ? -20.01058 -12.36131 -71.71885 1.000 43.91260 ? 385 ALA   B N   1 
ATOM   4998 C  CA  . ALA   B 1 385 ? -20.43703 -13.13187 -72.88278 1.000 45.71013 ? 385 ALA   B CA  1 
ATOM   4999 C  C   . ALA   B 1 385 ? -20.56790 -14.60593 -72.52544 1.000 44.82477 ? 385 ALA   B C   1 
ATOM   5000 O  O   . ALA   B 1 385 ? -21.60218 -15.22640 -72.78614 1.000 43.95887 ? 385 ALA   B O   1 
ATOM   5001 C  CB  . ALA   B 1 385 ? -19.45631 -12.94238 -74.04132 1.000 39.54910 ? 385 ALA   B CB  1 
ATOM   5002 N  N   . ASP   B 1 386 ? -19.52069 -15.17240 -71.91434 1.000 35.77515 ? 386 ASP   B N   1 
ATOM   5003 C  CA  . ASP   B 1 386 ? -19.57104 -16.51561 -71.34995 1.000 48.32558 ? 386 ASP   B CA  1 
ATOM   5004 C  C   . ASP   B 1 386 ? -20.84831 -16.75313 -70.54405 1.000 47.61649 ? 386 ASP   B C   1 
ATOM   5005 O  O   . ASP   B 1 386 ? -21.51428 -17.77823 -70.70423 1.000 56.52000 ? 386 ASP   B O   1 
ATOM   5006 C  CB  . ASP   B 1 386 ? -18.33204 -16.74497 -70.47714 1.000 41.83197 ? 386 ASP   B CB  1 
ATOM   5007 C  CG  . ASP   B 1 386 ? -17.03568 -16.75777 -71.28226 1.000 48.34598 ? 386 ASP   B CG  1 
ATOM   5008 O  OD1 . ASP   B 1 386 ? -17.07309 -16.47847 -72.49976 1.000 49.65895 ? 386 ASP   B OD1 1 
ATOM   5009 O  OD2 . ASP   B 1 386 ? -15.96939 -17.04769 -70.69709 1.000 49.99981 ? 386 ASP   B OD2 1 
ATOM   5010 N  N   . LEU   B 1 387 ? -21.22519 -15.79461 -69.69803 1.000 45.88576 ? 387 LEU   B N   1 
ATOM   5011 C  CA  . LEU   B 1 387 ? -22.37761 -15.98680 -68.82350 1.000 47.15824 ? 387 LEU   B CA  1 
ATOM   5012 C  C   . LEU   B 1 387 ? -23.66411 -16.17433 -69.62641 1.000 54.28845 ? 387 LEU   B C   1 
ATOM   5013 O  O   . LEU   B 1 387 ? -24.40049 -17.14657 -69.42064 1.000 52.84301 ? 387 LEU   B O   1 
ATOM   5014 C  CB  . LEU   B 1 387 ? -22.49938 -14.80146 -67.86733 1.000 42.15502 ? 387 LEU   B CB  1 
ATOM   5015 C  CG  . LEU   B 1 387 ? -23.29283 -14.97808 -66.57730 1.000 40.29135 ? 387 LEU   B CG  1 
ATOM   5016 C  CD1 . LEU   B 1 387 ? -22.49239 -15.76972 -65.55174 1.000 37.61725 ? 387 LEU   B CD1 1 
ATOM   5017 C  CD2 . LEU   B 1 387 ? -23.67423 -13.61694 -66.03697 1.000 37.06337 ? 387 LEU   B CD2 1 
ATOM   5018 N  N   . VAL   B 1 388 ? -23.94787 -15.25917 -70.55486 1.000 47.77158 ? 388 VAL   B N   1 
ATOM   5019 C  CA  . VAL   B 1 388 ? -25.17809 -15.30205 -71.33866 1.000 50.01359 ? 388 VAL   B CA  1 
ATOM   5020 C  C   . VAL   B 1 388 ? -24.99178 -16.03929 -72.66510 1.000 51.68378 ? 388 VAL   B C   1 
ATOM   5021 O  O   . VAL   B 1 388 ? -25.88091 -15.99165 -73.52264 1.000 50.96439 ? 388 VAL   B O   1 
ATOM   5022 C  CB  . VAL   B 1 388 ? -25.72742 -13.88525 -71.57842 1.000 53.37681 ? 388 VAL   B CB  1 
ATOM   5023 C  CG1 . VAL   B 1 388 ? -25.81842 -13.12747 -70.27177 1.000 52.60299 ? 388 VAL   B CG1 1 
ATOM   5024 C  CG2 . VAL   B 1 388 ? -24.85067 -13.13372 -72.57240 1.000 50.99593 ? 388 VAL   B CG2 1 
ATOM   5025 N  N   . HIS   B 1 389 ? -23.85768 -16.71924 -72.84469 1.000 46.46597 ? 389 HIS   B N   1 
ATOM   5026 C  CA  . HIS   B 1 389 ? -23.43970 -17.40297 -74.08163 1.000 58.04371 ? 389 HIS   B CA  1 
ATOM   5027 C  C   . HIS   B 1 389 ? -24.56562 -18.00467 -74.93374 1.000 64.96997 ? 389 HIS   B C   1 
ATOM   5028 O  O   . HIS   B 1 389 ? -25.25461 -18.92585 -74.49330 1.000 60.59083 ? 389 HIS   B O   1 
ATOM   5029 C  CB  . HIS   B 1 389 ? -22.44005 -18.50658 -73.70212 1.000 53.07839 ? 389 HIS   B CB  1 
ATOM   5030 C  CG  . HIS   B 1 389 ? -21.65098 -19.04989 -74.85197 1.000 61.13965 ? 389 HIS   B CG  1 
ATOM   5031 N  ND1 . HIS   B 1 389 ? -22.01101 -18.85569 -76.16746 1.000 63.32326 ? 389 HIS   B ND1 1 
ATOM   5032 C  CD2 . HIS   B 1 389 ? -20.52315 -19.80062 -74.87802 1.000 56.53699 ? 389 HIS   B CD2 1 
ATOM   5033 C  CE1 . HIS   B 1 389 ? -21.13712 -19.45749 -76.95491 1.000 68.16898 ? 389 HIS   B CE1 1 
ATOM   5034 N  NE2 . HIS   B 1 389 ? -20.22437 -20.04005 -76.19684 1.000 55.24383 ? 389 HIS   B NE2 1 
ATOM   5035 N  N   . PRO   B 1 390 ? -24.73494 -17.50235 -76.17285 1.000 69.34171 ? 390 PRO   B N   1 
ATOM   5036 C  CA  . PRO   B 1 390 ? -23.98783 -16.43155 -76.83728 1.000 60.72576 ? 390 PRO   B CA  1 
ATOM   5037 C  C   . PRO   B 1 390 ? -24.84862 -15.22711 -77.12750 1.000 65.60312 ? 390 PRO   B C   1 
ATOM   5038 O  O   . PRO   B 1 390 ? -24.80551 -14.64240 -78.20684 1.000 72.86649 ? 390 PRO   B O   1 
ATOM   5039 C  CB  . PRO   B 1 390 ? -23.57465 -17.08137 -78.14670 1.000 66.60008 ? 390 PRO   B CB  1 
ATOM   5040 C  CG  . PRO   B 1 390 ? -24.72798 -18.07396 -78.43436 1.000 62.26340 ? 390 PRO   B CG  1 
ATOM   5041 C  CD  . PRO   B 1 390 ? -25.55790 -18.21313 -77.16245 1.000 68.10886 ? 390 PRO   B CD  1 
ATOM   5042 N  N   . ASP   B 1 391 ? -25.65537 -14.86101 -76.14685 1.000 63.53329 ? 391 ASP   B N   1 
ATOM   5043 C  CA  . ASP   B 1 391 ? -26.65865 -13.83436 -76.36492 1.000 64.23814 ? 391 ASP   B CA  1 
ATOM   5044 C  C   . ASP   B 1 391 ? -26.07456 -12.43808 -76.42611 1.000 64.99984 ? 391 ASP   B C   1 
ATOM   5045 O  O   . ASP   B 1 391 ? -26.78556 -11.49556 -76.79395 1.000 61.25757 ? 391 ASP   B O   1 
ATOM   5046 C  CB  . ASP   B 1 391 ? -27.68948 -13.92554 -75.25661 1.000 64.75633 ? 391 ASP   B CB  1 
ATOM   5047 C  CG  . ASP   B 1 391 ? -28.49684 -15.19705 -75.34139 1.000 66.85339 ? 391 ASP   B CG  1 
ATOM   5048 O  OD1 . ASP   B 1 391 ? -27.85514 -16.25609 -75.62314 1.000 71.83620 ? 391 ASP   B OD1 1 
ATOM   5049 O  OD2 . ASP   B 1 391 ? -29.75457 -15.10369 -75.16680 1.000 54.67373 ? 391 ASP   B OD2 1 
ATOM   5050 N  N   . ALA   B 1 392 ? -24.83356 -12.28215 -76.00038 1.000 63.98144 ? 392 ALA   B N   1 
ATOM   5051 C  CA  . ALA   B 1 392 ? -24.10161 -11.03462 -76.10283 1.000 60.58390 ? 392 ALA   B CA  1 
ATOM   5052 C  C   . ALA   B 1 392 ? -23.03434 -11.16194 -77.18018 1.000 52.87978 ? 392 ALA   B C   1 
ATOM   5053 O  O   . ALA   B 1 392 ? -21.90062 -10.71848 -77.00959 1.000 50.36521 ? 392 ALA   B O   1 
ATOM   5054 C  CB  . ALA   B 1 392 ? -23.49000 -10.66223 -74.75649 1.000 44.20517 ? 392 ALA   B CB  1 
ATOM   5055 N  N   . GLN   B 1 393 ? -23.37238 -11.82580 -78.28503 1.000 54.86998 ? 393 GLN   B N   1 
ATOM   5056 C  CA  . GLN   B 1 393 ? -22.42662 -11.91273 -79.39011 1.000 52.05268 ? 393 GLN   B CA  1 
ATOM   5057 C  C   . GLN   B 1 393 ? -22.49759 -10.67246 -80.26969 1.000 37.90144 ? 393 GLN   B C   1 
ATOM   5058 O  O   . GLN   B 1 393 ? -21.46953 -10.06151 -80.56470 1.000 39.70468 ? 393 GLN   B O   1 
ATOM   5059 C  CB  . GLN   B 1 393 ? -22.67229 -13.16661 -80.22637 1.000 47.48502 ? 393 GLN   B CB  1 
ATOM   5060 C  CG  . GLN   B 1 393 ? -21.44420 -13.57881 -80.99606 1.000 43.92711 ? 393 GLN   B CG  1 
ATOM   5061 C  CD  . GLN   B 1 393 ? -20.40551 -14.20563 -80.09382 1.000 50.51882 ? 393 GLN   B CD  1 
ATOM   5062 O  OE1 . GLN   B 1 393 ? -20.63208 -15.26991 -79.51361 1.000 46.04858 ? 393 GLN   B OE1 1 
ATOM   5063 N  NE2 . GLN   B 1 393 ? -19.26080 -13.54013 -79.95532 1.000 48.97337 ? 393 GLN   B NE2 1 
ATOM   5064 N  N   . ASP   B 1 394 ? -23.70601 -10.27231 -80.66710 1.000 41.54358 ? 394 ASP   B N   1 
ATOM   5065 C  CA  . ASP   B 1 394 ? -23.87497 -8.99961  -81.35638 1.000 43.31916 ? 394 ASP   B CA  1 
ATOM   5066 C  C   . ASP   B 1 394 ? -23.34661 -7.81877  -80.53840 1.000 45.57185 ? 394 ASP   B C   1 
ATOM   5067 O  O   . ASP   B 1 394 ? -23.08849 -6.75464  -81.11278 1.000 38.91382 ? 394 ASP   B O   1 
ATOM   5068 C  CB  . ASP   B 1 394 ? -25.34978 -8.79664  -81.70508 1.000 38.83465 ? 394 ASP   B CB  1 
ATOM   5069 C  CG  . ASP   B 1 394 ? -25.84485 -9.79303  -82.73909 1.000 46.24557 ? 394 ASP   B CG  1 
ATOM   5070 O  OD1 . ASP   B 1 394 ? -25.19267 -10.85279 -82.91532 1.000 41.31749 ? 394 ASP   B OD1 1 
ATOM   5071 O  OD2 . ASP   B 1 394 ? -26.88893 -9.51822  -83.36995 1.000 40.50762 ? 394 ASP   B OD2 1 
ATOM   5072 N  N   . ILE   B 1 395 ? -23.17900 -7.97900  -79.22272 1.000 47.03470 ? 395 ILE   B N   1 
ATOM   5073 C  CA  . ILE   B 1 395 ? -22.57275 -6.93902  -78.38599 1.000 45.25784 ? 395 ILE   B CA  1 
ATOM   5074 C  C   . ILE   B 1 395 ? -21.05623 -7.06362  -78.36166 1.000 37.74692 ? 395 ILE   B C   1 
ATOM   5075 O  O   . ILE   B 1 395 ? -20.33698 -6.08831  -78.59441 1.000 41.69261 ? 395 ILE   B O   1 
ATOM   5076 C  CB  . ILE   B 1 395 ? -23.14876 -6.97638  -76.95169 1.000 40.90416 ? 395 ILE   B CB  1 
ATOM   5077 C  CG1 . ILE   B 1 395 ? -24.66560 -6.85290  -76.96237 1.000 31.25256 ? 395 ILE   B CG1 1 
ATOM   5078 C  CG2 . ILE   B 1 395 ? -22.55245 -5.84722  -76.09843 1.000 34.85053 ? 395 ILE   B CG2 1 
ATOM   5079 C  CD1 . ILE   B 1 395 ? -25.26712 -7.15069  -75.61357 1.000 35.15706 ? 395 ILE   B CD1 1 
ATOM   5080 N  N   . LEU   B 1 396 ? -20.53332 -8.25336  -78.07182 1.000 33.87696 ? 396 LEU   B N   1 
ATOM   5081 C  CA  . LEU   B 1 396 ? -19.08380 -8.40011  -78.01564 1.000 31.64785 ? 396 LEU   B CA  1 
ATOM   5082 C  C   . LEU   B 1 396 ? -18.44192 -8.22541  -79.39377 1.000 42.55346 ? 396 LEU   B C   1 
ATOM   5083 O  O   . LEU   B 1 396 ? -17.28195 -7.79882  -79.48813 1.000 35.89487 ? 396 LEU   B O   1 
ATOM   5084 C  CB  . LEU   B 1 396 ? -18.72368 -9.75487  -77.41555 1.000 28.00359 ? 396 LEU   B CB  1 
ATOM   5085 C  CG  . LEU   B 1 396 ? -17.23183 -10.06976 -77.28605 1.000 33.71469 ? 396 LEU   B CG  1 
ATOM   5086 C  CD1 . LEU   B 1 396 ? -16.60506 -9.30165  -76.12301 1.000 32.42008 ? 396 LEU   B CD1 1 
ATOM   5087 C  CD2 . LEU   B 1 396 ? -16.99903 -11.58822 -77.14887 1.000 33.33668 ? 396 LEU   B CD2 1 
ATOM   5088 N  N   . ASP   B 1 397 ? -19.16971 -8.55217  -80.46999 1.000 46.43345 ? 397 ASP   B N   1 
ATOM   5089 C  CA  . ASP   B 1 397 ? -18.63207 -8.36713  -81.81782 1.000 41.09579 ? 397 ASP   B CA  1 
ATOM   5090 C  C   . ASP   B 1 397 ? -18.39921 -6.89140  -82.10540 1.000 32.25317 ? 397 ASP   B C   1 
ATOM   5091 O  O   . ASP   B 1 397 ? -17.32013 -6.49573  -82.54759 1.000 33.22636 ? 397 ASP   B O   1 
ATOM   5092 C  CB  . ASP   B 1 397 ? -19.58504 -8.96480  -82.85934 1.000 38.28030 ? 397 ASP   B CB  1 
ATOM   5093 C  CG  . ASP   B 1 397 ? -19.62683 -10.48666 -82.81919 1.000 34.74458 ? 397 ASP   B CG  1 
ATOM   5094 O  OD1 . ASP   B 1 397 ? -18.58993 -11.10639 -82.50244 1.000 39.41337 ? 397 ASP   B OD1 1 
ATOM   5095 O  OD2 . ASP   B 1 397 ? -20.69820 -11.05906 -83.10656 1.000 40.70919 ? 397 ASP   B OD2 1 
ATOM   5096 N  N   . THR   B 1 398 ? -19.41997 -6.06860  -81.85862 1.000 33.42568 ? 398 THR   B N   1 
ATOM   5097 C  CA  . THR   B 1 398 ? -19.33576 -4.62784  -82.05189 1.000 36.07596 ? 398 THR   B CA  1 
ATOM   5098 C  C   . THR   B 1 398 ? -18.17832 -4.01257  -81.28731 1.000 41.08474 ? 398 THR   B C   1 
ATOM   5099 O  O   . THR   B 1 398 ? -17.61219 -2.99599  -81.71585 1.000 37.46853 ? 398 THR   B O   1 
ATOM   5100 C  CB  . THR   B 1 398 ? -20.64317 -3.98966  -81.59780 1.000 43.13426 ? 398 THR   B CB  1 
ATOM   5101 O  OG1 . THR   B 1 398 ? -21.72956 -4.83327  -82.00487 1.000 50.01504 ? 398 THR   B OG1 1 
ATOM   5102 C  CG2 . THR   B 1 398 ? -20.82285 -2.61383  -82.22277 1.000 38.28738 ? 398 THR   B CG2 1 
ATOM   5103 N  N   . LEU   B 1 399 ? -17.85539 -4.57622  -80.11952 1.000 35.35326 ? 399 LEU   B N   1 
ATOM   5104 C  CA  . LEU   B 1 399 ? -16.75671 -4.04056  -79.32720 1.000 28.73634 ? 399 LEU   B CA  1 
ATOM   5105 C  C   . LEU   B 1 399 ? -15.42850 -4.28541  -80.02223 1.000 32.63805 ? 399 LEU   B C   1 
ATOM   5106 O  O   . LEU   B 1 399 ? -14.56335 -3.40452  -80.05517 1.000 27.02500 ? 399 LEU   B O   1 
ATOM   5107 C  CB  . LEU   B 1 399 ? -16.76693 -4.66087  -77.92508 1.000 31.70002 ? 399 LEU   B CB  1 
ATOM   5108 C  CG  . LEU   B 1 399 ? -15.62473 -4.37733  -76.94124 1.000 27.10148 ? 399 LEU   B CG  1 
ATOM   5109 C  CD1 . LEU   B 1 399 ? -15.50274 -2.88885  -76.65769 1.000 18.70808 ? 399 LEU   B CD1 1 
ATOM   5110 C  CD2 . LEU   B 1 399 ? -15.83661 -5.15802  -75.64130 1.000 27.73530 ? 399 LEU   B CD2 1 
ATOM   5111 N  N   . GLU   B 1 400 ? -15.24981 -5.47865  -80.58671 1.000 32.43363 ? 400 GLU   B N   1 
ATOM   5112 C  CA  . GLU   B 1 400 ? -14.03145 -5.76568  -81.32716 1.000 29.66056 ? 400 GLU   B CA  1 
ATOM   5113 C  C   . GLU   B 1 400 ? -13.93554 -4.90373  -82.58396 1.000 30.86896 ? 400 GLU   B C   1 
ATOM   5114 O  O   . GLU   B 1 400 ? -12.84626 -4.44867  -82.95185 1.000 35.52489 ? 400 GLU   B O   1 
ATOM   5115 C  CB  . GLU   B 1 400 ? -13.98342 -7.25518  -81.66956 1.000 41.29993 ? 400 GLU   B CB  1 
ATOM   5116 C  CG  . GLU   B 1 400 ? -13.35692 -8.10538  -80.57444 1.000 40.87498 ? 400 GLU   B CG  1 
ATOM   5117 C  CD  . GLU   B 1 400 ? -14.07484 -9.42114  -80.36996 1.000 46.10656 ? 400 GLU   B CD  1 
ATOM   5118 O  OE1 . GLU   B 1 400 ? -13.40783 -10.40092 -79.96121 1.000 53.90345 ? 400 GLU   B OE1 1 
ATOM   5119 O  OE2 . GLU   B 1 400 ? -15.30006 -9.46879  -80.61259 1.000 39.37124 ? 400 GLU   B OE2 1 
ATOM   5120 N  N   . ASP   B 1 401 ? -15.06643 -4.66129  -83.24745 1.000 27.97439 ? 401 ASP   B N   1 
ATOM   5121 C  CA  . ASP   B 1 401 ? -15.08970 -3.76006  -84.39705 1.000 29.67027 ? 401 ASP   B CA  1 
ATOM   5122 C  C   . ASP   B 1 401 ? -14.69396 -2.35047  -83.98401 1.000 32.58872 ? 401 ASP   B C   1 
ATOM   5123 O  O   . ASP   B 1 401 ? -13.77326 -1.75550  -84.55334 1.000 35.65005 ? 401 ASP   B O   1 
ATOM   5124 C  CB  . ASP   B 1 401 ? -16.47918 -3.73929  -85.03226 1.000 22.95091 ? 401 ASP   B CB  1 
ATOM   5125 C  CG  . ASP   B 1 401 ? -16.88344 -5.07733  -85.56843 1.000 27.33005 ? 401 ASP   B CG  1 
ATOM   5126 O  OD1 . ASP   B 1 401 ? -16.01111 -5.95496  -85.63628 1.000 25.29739 ? 401 ASP   B OD1 1 
ATOM   5127 O  OD2 . ASP   B 1 401 ? -18.06046 -5.24959  -85.93528 1.000 23.03687 ? 401 ASP   B OD2 1 
ATOM   5128 N  N   . ASN   B 1 402 ? -15.40588 -1.79577  -82.99947 1.000 31.18940 ? 402 ASN   B N   1 
ATOM   5129 C  CA  . ASN   B 1 402 ? -15.10538 -0.45908  -82.51307 1.000 24.75803 ? 402 ASN   B CA  1 
ATOM   5130 C  C   . ASN   B 1 402 ? -13.65512 -0.34790  -82.06031 1.000 24.12773 ? 402 ASN   B C   1 
ATOM   5131 O  O   . ASN   B 1 402 ? -12.98717 0.65545   -82.34341 1.000 21.12172 ? 402 ASN   B O   1 
ATOM   5132 C  CB  . ASN   B 1 402 ? -16.07535 -0.10096  -81.39061 1.000 21.16427 ? 402 ASN   B CB  1 
ATOM   5133 C  CG  . ASN   B 1 402 ? -17.48271 0.16994   -81.90495 1.000 24.90638 ? 402 ASN   B CG  1 
ATOM   5134 O  OD1 . ASN   B 1 402 ? -17.68019 0.42756   -83.09382 1.000 31.23729 ? 402 ASN   B OD1 1 
ATOM   5135 N  ND2 . ASN   B 1 402 ? -18.46198 0.15588   -81.00482 1.000 22.93234 ? 402 ASN   B ND2 1 
ATOM   5136 N  N   . ARG   B 1 403 ? -13.13379 -1.38530  -81.39600 1.000 24.15388 ? 403 ARG   B N   1 
ATOM   5137 C  CA  . ARG   B 1 403 ? -11.74153 -1.34689  -80.95775 1.000 19.79357 ? 403 ARG   B CA  1 
ATOM   5138 C  C   . ARG   B 1 403 ? -10.79291 -1.31713  -82.13864 1.000 25.55513 ? 403 ARG   B C   1 
ATOM   5139 O  O   . ARG   B 1 403 ? -9.75184  -0.65194  -82.08962 1.000 25.52943 ? 403 ARG   B O   1 
ATOM   5140 C  CB  . ARG   B 1 403 ? -11.42006 -2.54928  -80.07661 1.000 28.69821 ? 403 ARG   B CB  1 
ATOM   5141 C  CG  . ARG   B 1 403 ? -10.00832 -2.52949  -79.48430 1.000 19.65181 ? 403 ARG   B CG  1 
ATOM   5142 C  CD  . ARG   B 1 403 ? -9.10342  -3.50323  -80.14581 1.000 16.43543 ? 403 ARG   B CD  1 
ATOM   5143 N  NE  . ARG   B 1 403 ? -7.90456  -3.72716  -79.35107 1.000 25.67920 ? 403 ARG   B NE  1 
ATOM   5144 C  CZ  . ARG   B 1 403 ? -6.66142  -3.57654  -79.79377 1.000 21.51737 ? 403 ARG   B CZ  1 
ATOM   5145 N  NH1 . ARG   B 1 403 ? -6.45020  -3.19152  -81.03875 1.000 21.27957 ? 403 ARG   B NH1 1 
ATOM   5146 N  NH2 . ARG   B 1 403 ? -5.62948  -3.82457  -78.98989 1.000 17.92353 ? 403 ARG   B NH2 1 
ATOM   5147 N  N   . GLU   B 1 404 ? -11.11457 -2.07119  -83.19095 1.000 27.62213 ? 404 GLU   B N   1 
ATOM   5148 C  CA  . GLU   B 1 404 ? -10.25751 -2.11950  -84.36655 1.000 24.11999 ? 404 GLU   B CA  1 
ATOM   5149 C  C   . GLU   B 1 404 ? -10.25141 -0.77842  -85.08616 1.000 20.59126 ? 404 GLU   B C   1 
ATOM   5150 O  O   . GLU   B 1 404 ? -9.21022  -0.33056  -85.57629 1.000 22.32054 ? 404 GLU   B O   1 
ATOM   5151 C  CB  . GLU   B 1 404 ? -10.74327 -3.22779  -85.29375 1.000 27.08620 ? 404 GLU   B CB  1 
ATOM   5152 C  CG  . GLU   B 1 404 ? -9.80338  -3.59869  -86.41861 1.000 28.33003 ? 404 GLU   B CG  1 
ATOM   5153 C  CD  . GLU   B 1 404 ? -10.39932 -4.65767  -87.33221 1.000 27.57905 ? 404 GLU   B CD  1 
ATOM   5154 O  OE1 . GLU   B 1 404 ? -11.56767 -4.51588  -87.74244 1.000 23.20294 ? 404 GLU   B OE1 1 
ATOM   5155 O  OE2 . GLU   B 1 404 ? -9.70471  -5.64181  -87.62399 1.000 27.38542 ? 404 GLU   B OE2 1 
ATOM   5156 N  N   . TRP   B 1 405 ? -11.41007 -0.12779  -85.15738 1.000 19.44946 ? 405 TRP   B N   1 
ATOM   5157 C  CA  . TRP   B 1 405 ? -11.49407 1.18825   -85.77046 1.000 21.75249 ? 405 TRP   B CA  1 
ATOM   5158 C  C   . TRP   B 1 405 ? -10.64763 2.20505   -85.01532 1.000 23.64332 ? 405 TRP   B C   1 
ATOM   5159 O  O   . TRP   B 1 405 ? -9.77512  2.85826   -85.60092 1.000 22.31718 ? 405 TRP   B O   1 
ATOM   5160 C  CB  . TRP   B 1 405 ? -12.94308 1.64029   -85.83026 1.000 20.25240 ? 405 TRP   B CB  1 
ATOM   5161 C  CG  . TRP   B 1 405 ? -13.08202 2.96008   -86.50808 1.000 26.59600 ? 405 TRP   B CG  1 
ATOM   5162 C  CD1 . TRP   B 1 405 ? -13.20733 3.18546   -87.85524 1.000 21.85663 ? 405 TRP   B CD1 1 
ATOM   5163 C  CD2 . TRP   B 1 405 ? -13.10238 4.24993   -85.87972 1.000 25.43593 ? 405 TRP   B CD2 1 
ATOM   5164 N  NE1 . TRP   B 1 405 ? -13.32288 4.53311   -88.09778 1.000 24.46329 ? 405 TRP   B NE1 1 
ATOM   5165 C  CE2 . TRP   B 1 405 ? -13.25482 5.20957   -86.90432 1.000 25.12932 ? 405 TRP   B CE2 1 
ATOM   5166 C  CE3 . TRP   B 1 405 ? -13.01494 4.68510   -84.55037 1.000 24.98199 ? 405 TRP   B CE3 1 
ATOM   5167 C  CZ2 . TRP   B 1 405 ? -13.32659 6.57774   -86.64280 1.000 24.73271 ? 405 TRP   B CZ2 1 
ATOM   5168 C  CZ3 . TRP   B 1 405 ? -13.07875 6.05318   -84.29342 1.000 25.65140 ? 405 TRP   B CZ3 1 
ATOM   5169 C  CH2 . TRP   B 1 405 ? -13.22782 6.97847   -85.33630 1.000 27.91449 ? 405 TRP   B CH2 1 
ATOM   5170 N  N   . TYR   B 1 406 ? -10.88866 2.35342   -83.70327 1.000 22.46994 ? 406 TYR   B N   1 
ATOM   5171 C  CA  . TYR   B 1 406 ? -10.08642 3.28850   -82.92056 1.000 19.10221 ? 406 TYR   B CA  1 
ATOM   5172 C  C   . TYR   B 1 406 ? -8.60005  3.00179   -83.05706 1.000 19.41513 ? 406 TYR   B C   1 
ATOM   5173 O  O   . TYR   B 1 406 ? -7.79278  3.93432   -83.10209 1.000 17.93754 ? 406 TYR   B O   1 
ATOM   5174 C  CB  . TYR   B 1 406 ? -10.48726 3.26480   -81.45376 1.000 20.95457 ? 406 TYR   B CB  1 
ATOM   5175 C  CG  . TYR   B 1 406 ? -11.46176 4.35096   -81.07020 1.000 16.87187 ? 406 TYR   B CG  1 
ATOM   5176 C  CD1 . TYR   B 1 406 ? -11.03012 5.65286   -80.84410 1.000 19.56516 ? 406 TYR   B CD1 1 
ATOM   5177 C  CD2 . TYR   B 1 406 ? -12.81082 4.06990   -80.90623 1.000 12.45217 ? 406 TYR   B CD2 1 
ATOM   5178 C  CE1 . TYR   B 1 406 ? -11.92529 6.65033   -80.47570 1.000 16.38740 ? 406 TYR   B CE1 1 
ATOM   5179 C  CE2 . TYR   B 1 406 ? -13.71526 5.06038   -80.54885 1.000 19.32535 ? 406 TYR   B CE2 1 
ATOM   5180 C  CZ  . TYR   B 1 406 ? -13.26451 6.34935   -80.33159 1.000 18.10585 ? 406 TYR   B CZ  1 
ATOM   5181 O  OH  . TYR   B 1 406 ? -14.16454 7.32459   -79.96640 1.000 19.47400 ? 406 TYR   B OH  1 
ATOM   5182 N  N   . GLN   B 1 407 ? -8.21089  1.72572   -83.14230 1.000 21.27398 ? 407 GLN   B N   1 
ATOM   5183 C  CA  . GLN   B 1 407 ? -6.79902  1.42764   -83.39324 1.000 20.26138 ? 407 GLN   B CA  1 
ATOM   5184 C  C   . GLN   B 1 407 ? -6.36908  1.92278   -84.76663 1.000 23.63910 ? 407 GLN   B C   1 
ATOM   5185 O  O   . GLN   B 1 407 ? -5.23817  2.39082   -84.94347 1.000 27.05572 ? 407 GLN   B O   1 
ATOM   5186 C  CB  . GLN   B 1 407 ? -6.52110  -0.07081  -83.27518 1.000 23.73653 ? 407 GLN   B CB  1 
ATOM   5187 C  CG  . GLN   B 1 407 ? -5.07499  -0.44854  -83.59642 1.000 16.08118 ? 407 GLN   B CG  1 
ATOM   5188 C  CD  . GLN   B 1 407 ? -4.06999  0.12292   -82.58785 1.000 24.57369 ? 407 GLN   B CD  1 
ATOM   5189 O  OE1 . GLN   B 1 407 ? -4.12904  -0.17472  -81.39060 1.000 24.70499 ? 407 GLN   B OE1 1 
ATOM   5190 N  NE2 . GLN   B 1 407 ? -3.15107  0.95612   -83.07012 1.000 22.23704 ? 407 GLN   B NE2 1 
ATOM   5191 N  N   . SER   B 1 408 ? -7.25484  1.82503   -85.75608 1.000 21.98803 ? 408 SER   B N   1 
ATOM   5192 C  CA  . SER   B 1 408 ? -6.88606  2.28877   -87.08506 1.000 25.12417 ? 408 SER   B CA  1 
ATOM   5193 C  C   . SER   B 1 408 ? -6.72428  3.80173   -87.14427 1.000 21.56568 ? 408 SER   B C   1 
ATOM   5194 O  O   . SER   B 1 408 ? -5.95382  4.29028   -87.98074 1.000 21.18593 ? 408 SER   B O   1 
ATOM   5195 C  CB  . SER   B 1 408 ? -7.91278  1.82147   -88.12709 1.000 17.47427 ? 408 SER   B CB  1 
ATOM   5196 O  OG  . SER   B 1 408 ? -9.12359  2.54170   -88.04250 1.000 14.84249 ? 408 SER   B OG  1 
ATOM   5197 N  N   . THR   B 1 409 ? -7.42099  4.55574   -86.28566 1.000 21.64872 ? 409 THR   B N   1 
ATOM   5198 C  CA  . THR   B 1 409 ? -7.18450  5.99652   -86.25982 1.000 20.31443 ? 409 THR   B CA  1 
ATOM   5199 C  C   . THR   B 1 409 ? -5.84117  6.36679   -85.64670 1.000 21.11332 ? 409 THR   B C   1 
ATOM   5200 O  O   . THR   B 1 409 ? -5.49073  7.54741   -85.65298 1.000 22.67789 ? 409 THR   B O   1 
ATOM   5201 C  CB  . THR   B 1 409 ? -8.28266  6.72830   -85.49148 1.000 19.44451 ? 409 THR   B CB  1 
ATOM   5202 O  OG1 . THR   B 1 409 ? -8.13550  6.47483   -84.09019 1.000 22.21237 ? 409 THR   B OG1 1 
ATOM   5203 C  CG2 . THR   B 1 409 ? -9.64536  6.27576   -85.95274 1.000 18.33751 ? 409 THR   B CG2 1 
ATOM   5204 N  N   . ILE   B 1 410 ? -5.10658  5.40763   -85.09773 1.000 23.85823 ? 410 ILE   B N   1 
ATOM   5205 C  CA  . ILE   B 1 410 ? -3.77439  5.65852   -84.54382 1.000 25.35405 ? 410 ILE   B CA  1 
ATOM   5206 C  C   . ILE   B 1 410 ? -2.75216  5.40333   -85.63766 1.000 28.04843 ? 410 ILE   B C   1 
ATOM   5207 O  O   . ILE   B 1 410 ? -2.58885  4.25441   -86.06406 1.000 24.04702 ? 410 ILE   B O   1 
ATOM   5208 C  CB  . ILE   B 1 410 ? -3.48126  4.75455   -83.33918 1.000 19.40456 ? 410 ILE   B CB  1 
ATOM   5209 C  CG1 . ILE   B 1 410 ? -4.46374  5.00092   -82.18503 1.000 22.84695 ? 410 ILE   B CG1 1 
ATOM   5210 C  CG2 . ILE   B 1 410 ? -2.04790  4.95746   -82.90848 1.000 18.05685 ? 410 ILE   B CG2 1 
ATOM   5211 C  CD1 . ILE   B 1 410 ? -4.60628  3.80512   -81.26966 1.000 17.93987 ? 410 ILE   B CD1 1 
ATOM   5212 N  N   . PRO   B 1 411 ? -2.00820  6.41979   -86.09468 1.000 29.65259 ? 411 PRO   B N   1 
ATOM   5213 C  CA  . PRO   B 1 411 ? -0.86607  6.03124   -86.92518 1.000 28.60780 ? 411 PRO   B CA  1 
ATOM   5214 C  C   . PRO   B 1 411 ? 0.25621   5.45944   -86.05659 1.000 27.24882 ? 411 PRO   B C   1 
ATOM   5215 O  O   . PRO   B 1 411 ? 1.21136   4.88183   -86.58878 1.000 40.48463 ? 411 PRO   B O   1 
ATOM   5216 C  CB  . PRO   B 1 411 ? -0.45787  7.34484   -87.60230 1.000 21.49085 ? 411 PRO   B CB  1 
ATOM   5217 C  CG  . PRO   B 1 411 ? -0.94955  8.44457   -86.66044 1.000 20.92055 ? 411 PRO   B CG  1 
ATOM   5218 C  CD  . PRO   B 1 411 ? -2.20664  7.88326   -86.02509 1.000 30.32913 ? 411 PRO   B CD  1 
HETATM 5219 ZN ZN  . ZN    C 2 .   ? -19.05627 3.39753   -28.44092 1.000 12.79865 ? 601 ZN    A ZN  1 
HETATM 5220 MG MG  . MG    D 3 .   ? -20.71304 3.43681   -31.80614 1.000 7.35381  ? 602 MG    A MG  1 
HETATM 5221 O  O33 . A1EKX E 4 .   ? -27.69698 -5.03370  -32.47379 1.000 55.98088 ? 603 A1EKX A O33 1 
HETATM 5222 C  C30 . A1EKX E 4 .   ? -26.55979 -5.38712  -32.51101 1.000 51.07865 ? 603 A1EKX A C30 1 
HETATM 5223 O  O31 . A1EKX E 4 .   ? -25.81850 -5.20899  -33.70420 1.000 49.11878 ? 603 A1EKX A O31 1 
HETATM 5224 C  C32 . A1EKX E 4 .   ? -26.40247 -4.33124  -34.64807 1.000 38.60224 ? 603 A1EKX A C32 1 
HETATM 5225 C  C29 . A1EKX E 4 .   ? -25.94537 -6.00411  -31.36586 1.000 51.59669 ? 603 A1EKX A C29 1 
HETATM 5226 C  C28 . A1EKX E 4 .   ? -24.88195 -5.06514  -30.67622 1.000 43.76569 ? 603 A1EKX A C28 1 
HETATM 5227 N  N34 . A1EKX E 4 .   ? -26.98962 -6.31401  -30.27038 1.000 45.18707 ? 603 A1EKX A N34 1 
HETATM 5228 C  C35 . A1EKX E 4 .   ? -26.47313 -5.82504  -29.15304 1.000 44.41866 ? 603 A1EKX A C35 1 
HETATM 5229 C  C27 . A1EKX E 4 .   ? -25.41263 -4.65209  -29.55235 1.000 32.89539 ? 603 A1EKX A C27 1 
HETATM 5230 O  O26 . A1EKX E 4 .   ? -26.10961 -3.36736  -29.71202 1.000 39.26505 ? 603 A1EKX A O26 1 
HETATM 5231 C  C25 . A1EKX E 4 .   ? -25.19021 -2.25803  -29.80007 1.000 33.03528 ? 603 A1EKX A C25 1 
HETATM 5232 C  C2  . A1EKX E 4 .   ? -24.94599 -1.57366  -31.01030 1.000 29.82804 ? 603 A1EKX A C2  1 
HETATM 5233 O  O1  . A1EKX E 4 .   ? -25.60357 -1.94587  -32.20287 1.000 33.53497 ? 603 A1EKX A O1  1 
HETATM 5234 C  C6  . A1EKX E 4 .   ? -24.49663 -1.83074  -28.62171 1.000 34.51107 ? 603 A1EKX A C6  1 
HETATM 5235 O  O7  . A1EKX E 4 .   ? -24.56374 -2.32400  -27.37354 1.000 25.70486 ? 603 A1EKX A O7  1 
HETATM 5236 C  C8  . A1EKX E 4 .   ? -23.75165 -1.68699  -26.56025 1.000 24.58576 ? 603 A1EKX A C8  1 
HETATM 5237 C  C24 . A1EKX E 4 .   ? -23.08621 -0.65587  -27.26225 1.000 21.07878 ? 603 A1EKX A C24 1 
HETATM 5238 C  C5  . A1EKX E 4 .   ? -23.58176 -0.76982  -28.65139 1.000 30.90580 ? 603 A1EKX A C5  1 
HETATM 5239 C  C4  . A1EKX E 4 .   ? -23.34222 -0.08846  -29.87424 1.000 29.49842 ? 603 A1EKX A C4  1 
HETATM 5240 C  C3  . A1EKX E 4 .   ? -24.02502 -0.49810  -31.04363 1.000 27.48089 ? 603 A1EKX A C3  1 
HETATM 5241 C  C9  . A1EKX E 4 .   ? -23.66850 -2.03075  -25.06122 1.000 23.76765 ? 603 A1EKX A C9  1 
HETATM 5242 C  C23 . A1EKX E 4 .   ? -22.83764 -1.36598  -24.15050 1.000 24.14846 ? 603 A1EKX A C23 1 
HETATM 5243 C  C22 . A1EKX E 4 .   ? -22.85893 -1.73603  -22.78881 1.000 19.00349 ? 603 A1EKX A C22 1 
HETATM 5244 C  C17 . A1EKX E 4 .   ? -23.71695 -2.75307  -22.34706 1.000 23.37420 ? 603 A1EKX A C17 1 
HETATM 5245 O  O18 . A1EKX E 4 .   ? -23.79826 -3.15939  -20.98997 1.000 23.63976 ? 603 A1EKX A O18 1 
HETATM 5246 F  F21 . A1EKX E 4 .   ? -22.79852 -1.53726  -19.79168 1.000 22.12132 ? 603 A1EKX A F21 1 
HETATM 5247 F  F20 . A1EKX E 4 .   ? -21.53455 -3.13209  -20.72698 1.000 26.71208 ? 603 A1EKX A F20 1 
HETATM 5248 C  C19 . A1EKX E 4 .   ? -22.73523 -2.85347  -20.13543 1.000 20.51867 ? 603 A1EKX A C19 1 
HETATM 5249 C  C11 . A1EKX E 4 .   ? -24.56021 -3.39411  -23.27035 1.000 26.93542 ? 603 A1EKX A C11 1 
HETATM 5250 C  C10 . A1EKX E 4 .   ? -24.53813 -3.02719  -24.61533 1.000 25.58672 ? 603 A1EKX A C10 1 
HETATM 5251 O  O12 . A1EKX E 4 .   ? -25.44501 -4.42794  -22.86954 1.000 25.00161 ? 603 A1EKX A O12 1 
HETATM 5252 C  C13 . A1EKX E 4 .   ? -25.84309 -5.22713  -23.96465 1.000 23.64486 ? 603 A1EKX A C13 1 
HETATM 5253 C  C14 . A1EKX E 4 .   ? -27.21772 -5.81296  -23.61912 1.000 30.31638 ? 603 A1EKX A C14 1 
HETATM 5254 C  C16 . A1EKX E 4 .   ? -28.16071 -6.82992  -23.72209 1.000 36.04542 ? 603 A1EKX A C16 1 
HETATM 5255 C  C15 . A1EKX E 4 .   ? -28.43295 -5.69424  -22.95999 1.000 33.33865 ? 603 A1EKX A C15 1 
HETATM 5256 ZN ZN  . ZN    F 2 .   ? -22.42393 5.87724   -64.95462 1.000 21.25178 ? 601 ZN    B ZN  1 
HETATM 5257 MG MG  . MG    G 3 .   ? -21.19294 6.52891   -61.70066 1.000 13.88749 ? 602 MG    B MG  1 
HETATM 5258 O  O33 . A1EKX H 4 .   ? -11.15993 1.85498   -64.57347 1.000 51.27983 ? 603 A1EKX B O33 1 
HETATM 5259 C  C30 . A1EKX H 4 .   ? -10.49501 2.54029   -65.29101 1.000 53.62955 ? 603 A1EKX B C30 1 
HETATM 5260 O  O31 . A1EKX H 4 .   ? -9.10916  2.27504   -65.45501 1.000 60.49235 ? 603 A1EKX B O31 1 
HETATM 5261 C  C32 . A1EKX H 4 .   ? -8.58594  1.25443   -64.62410 1.000 55.54966 ? 603 A1EKX B C32 1 
HETATM 5262 C  C29 . A1EKX H 4 .   ? -11.09141 3.62617   -66.01312 1.000 48.17990 ? 603 A1EKX B C29 1 
HETATM 5263 C  C28 . A1EKX H 4 .   ? -12.31050 4.27201   -65.25912 1.000 41.02738 ? 603 A1EKX B C28 1 
HETATM 5264 N  N34 . A1EKX H 4 .   ? -10.05763 4.75181   -66.21794 1.000 56.55194 ? 603 A1EKX B N34 1 
HETATM 5265 C  C35 . A1EKX H 4 .   ? -10.57444 5.84451   -65.66614 1.000 54.15042 ? 603 A1EKX B C35 1 
HETATM 5266 C  C27 . A1EKX H 4 .   ? -12.16029 5.56531   -65.39075 1.000 45.51267 ? 603 A1EKX B C27 1 
HETATM 5267 O  O26 . A1EKX H 4 .   ? -12.65989 6.34778   -64.25040 1.000 40.39287 ? 603 A1EKX B O26 1 
HETATM 5268 C  C25 . A1EKX H 4 .   ? -14.09273 6.37841   -64.15953 1.000 37.21937 ? 603 A1EKX B C25 1 
HETATM 5269 C  C2  . A1EKX H 4 .   ? -14.68834 6.45128   -62.89737 1.000 38.19262 ? 603 A1EKX B C2  1 
HETATM 5270 O  O1  . A1EKX H 4 .   ? -13.85928 6.49530   -61.76008 1.000 41.98125 ? 603 A1EKX B O1  1 
HETATM 5271 C  C6  . A1EKX H 4 .   ? -14.93857 6.34235   -65.31972 1.000 36.47128 ? 603 A1EKX B C6  1 
HETATM 5272 O  O7  . A1EKX H 4 .   ? -14.60877 6.27330   -66.62318 1.000 36.19235 ? 603 A1EKX B O7  1 
HETATM 5273 C  C8  . A1EKX H 4 .   ? -15.66444 6.23066   -67.39023 1.000 39.40289 ? 603 A1EKX B C8  1 
HETATM 5274 C  C24 . A1EKX H 4 .   ? -16.82759 6.30419   -66.58776 1.000 32.39361 ? 603 A1EKX B C24 1 
HETATM 5275 C  C5  . A1EKX H 4 .   ? -16.32978 6.37046   -65.19853 1.000 32.02960 ? 603 A1EKX B C5  1 
HETATM 5276 C  C4  . A1EKX H 4 .   ? -16.92799 6.43602   -63.91338 1.000 30.31036 ? 603 A1EKX B C4  1 
HETATM 5277 C  C3  . A1EKX H 4 .   ? -16.09997 6.47789   -62.77143 1.000 34.40748 ? 603 A1EKX B C3  1 
HETATM 5278 C  C9  . A1EKX H 4 .   ? -15.55938 6.19515   -68.92345 1.000 30.81152 ? 603 A1EKX B C9  1 
HETATM 5279 C  C23 . A1EKX H 4 .   ? -16.68778 6.27254   -69.75177 1.000 29.76656 ? 603 A1EKX B C23 1 
HETATM 5280 C  C22 . A1EKX H 4 .   ? -16.53078 6.28534   -71.14400 1.000 20.05500 ? 603 A1EKX B C22 1 
HETATM 5281 C  C17 . A1EKX H 4 .   ? -15.23622 6.22917   -71.68793 1.000 28.06488 ? 603 A1EKX B C17 1 
HETATM 5282 O  O18 . A1EKX H 4 .   ? -14.99758 6.22721   -73.07184 1.000 34.61383 ? 603 A1EKX B O18 1 
HETATM 5283 F  F21 . A1EKX H 4 .   ? -16.53108 4.56612   -73.32936 1.000 34.65486 ? 603 A1EKX B F21 1 
HETATM 5284 F  F20 . A1EKX H 4 .   ? -17.03501 6.68775   -73.90409 1.000 29.70132 ? 603 A1EKX B F20 1 
HETATM 5285 C  C19 . A1EKX H 4 .   ? -16.05140 5.73654   -73.85697 1.000 29.54132 ? 603 A1EKX B C19 1 
HETATM 5286 C  C11 . A1EKX H 4 .   ? -14.12241 6.17763   -70.85272 1.000 29.72583 ? 603 A1EKX B C11 1 
HETATM 5287 C  C10 . A1EKX H 4 .   ? -14.27476 6.16908   -69.46770 1.000 29.13238 ? 603 A1EKX B C10 1 
HETATM 5288 O  O12 . A1EKX H 4 .   ? -12.83338 6.13168   -71.40414 1.000 30.18998 ? 603 A1EKX B O12 1 
HETATM 5289 C  C13 . A1EKX H 4 .   ? -11.84520 6.20848   -70.40077 1.000 30.93837 ? 603 A1EKX B C13 1 
HETATM 5290 C  C14 . A1EKX H 4 .   ? -10.56420 6.59707   -71.13864 1.000 43.84211 ? 603 A1EKX B C14 1 
HETATM 5291 C  C16 . A1EKX H 4 .   ? -9.28832  6.28363   -71.57090 1.000 39.47855 ? 603 A1EKX B C16 1 
HETATM 5292 C  C15 . A1EKX H 4 .   ? -9.84667  7.51711   -71.89466 1.000 47.00358 ? 603 A1EKX B C15 1 
HETATM 5293 O  O   . HOH   I 5 .   ? 1.68463   -10.62754 -29.22796 1.000 34.07870 ? 701 HOH   A O   1 
HETATM 5294 O  O   . HOH   I 5 .   ? -19.44403 2.62630   -30.44004 1.000 3.89106  ? 702 HOH   A O   1 
HETATM 5295 O  O   . HOH   I 5 .   ? 1.91389   -18.39769 -34.29763 1.000 35.01052 ? 703 HOH   A O   1 
HETATM 5296 O  O   . HOH   I 5 .   ? 5.94590   17.79547  -23.62301 1.000 34.81472 ? 704 HOH   A O   1 
HETATM 5297 O  O   . HOH   I 5 .   ? -42.28806 -0.13384  -27.74026 1.000 43.21365 ? 705 HOH   A O   1 
HETATM 5298 O  O   . HOH   I 5 .   ? -4.99868  -8.14307  -41.63835 1.000 22.79211 ? 706 HOH   A O   1 
HETATM 5299 O  O   . HOH   I 5 .   ? -30.82844 2.49657   -28.06458 1.000 17.44762 ? 707 HOH   A O   1 
HETATM 5300 O  O   . HOH   I 5 .   ? -22.93023 19.37314  -19.09360 1.000 31.04499 ? 708 HOH   A O   1 
HETATM 5301 O  O   . HOH   I 5 .   ? -5.88577  14.20205  -46.78046 1.000 52.02058 ? 709 HOH   A O   1 
HETATM 5302 O  O   . HOH   I 5 .   ? 2.18670   3.37243   -26.08046 1.000 30.26726 ? 710 HOH   A O   1 
HETATM 5303 O  O   . HOH   I 5 .   ? -18.86572 -12.85350 -30.27917 1.000 16.75544 ? 711 HOH   A O   1 
HETATM 5304 O  O   . HOH   I 5 .   ? -20.96692 1.61559   -33.09934 1.000 9.06689  ? 712 HOH   A O   1 
HETATM 5305 O  O   . HOH   I 5 .   ? -1.95810  6.29389   -13.99079 1.000 22.91422 ? 713 HOH   A O   1 
HETATM 5306 O  O   . HOH   I 5 .   ? -12.22286 -15.50020 -10.39454 1.000 40.17057 ? 714 HOH   A O   1 
HETATM 5307 O  O   . HOH   I 5 .   ? 3.51774   17.03068  -25.73135 1.000 19.27266 ? 715 HOH   A O   1 
HETATM 5308 O  O   . HOH   I 5 .   ? -25.04764 -1.63197  -36.67983 1.000 19.85868 ? 716 HOH   A O   1 
HETATM 5309 O  O   . HOH   I 5 .   ? -10.47830 -4.75920  -12.52566 1.000 29.45812 ? 717 HOH   A O   1 
HETATM 5310 O  O   . HOH   I 5 .   ? -16.88756 24.54223  -26.89143 1.000 23.49428 ? 718 HOH   A O   1 
HETATM 5311 O  O   . HOH   I 5 .   ? -24.33745 -1.28200  -41.51282 1.000 21.07459 ? 719 HOH   A O   1 
HETATM 5312 O  O   . HOH   I 5 .   ? -10.32727 -8.35678  -37.20558 1.000 22.34656 ? 720 HOH   A O   1 
HETATM 5313 O  O   . HOH   I 5 .   ? -30.52297 6.17150   -49.05819 1.000 16.05709 ? 721 HOH   A O   1 
HETATM 5314 O  O   . HOH   I 5 .   ? -8.82387  28.21046  -37.47249 1.000 18.30086 ? 722 HOH   A O   1 
HETATM 5315 O  O   . HOH   I 5 .   ? -13.42361 -9.91937  -42.60709 1.000 28.34570 ? 723 HOH   A O   1 
HETATM 5316 O  O   . HOH   I 5 .   ? -19.26169 3.97822   -33.04214 1.000 6.12316  ? 724 HOH   A O   1 
HETATM 5317 O  O   . HOH   I 5 .   ? -12.12913 5.43874   -18.40627 1.000 16.94027 ? 725 HOH   A O   1 
HETATM 5318 O  O   . HOH   I 5 .   ? -10.91534 -7.78831  -39.83141 1.000 26.58467 ? 726 HOH   A O   1 
HETATM 5319 O  O   . HOH   I 5 .   ? -17.52045 -4.20534  -34.46717 1.000 10.54684 ? 727 HOH   A O   1 
HETATM 5320 O  O   . HOH   I 5 .   ? -18.20379 3.39500   -21.63442 1.000 9.03959  ? 728 HOH   A O   1 
HETATM 5321 O  O   . HOH   I 5 .   ? -45.09399 -0.12312  -30.48332 1.000 44.39686 ? 729 HOH   A O   1 
HETATM 5322 O  O   . HOH   I 5 .   ? -39.35317 0.47859   -22.93914 1.000 34.73293 ? 730 HOH   A O   1 
HETATM 5323 O  O   . HOH   I 5 .   ? -29.26247 -1.80986  -14.76523 1.000 19.09822 ? 731 HOH   A O   1 
HETATM 5324 O  O   . HOH   I 5 .   ? -3.47646  -11.56898 -21.82738 1.000 17.09385 ? 732 HOH   A O   1 
HETATM 5325 O  O   . HOH   I 5 .   ? 6.11499   -2.27098  -35.77447 1.000 21.03271 ? 733 HOH   A O   1 
HETATM 5326 O  O   . HOH   I 5 .   ? -23.63026 12.05247  -15.36322 1.000 27.75787 ? 734 HOH   A O   1 
HETATM 5327 O  O   . HOH   I 5 .   ? -36.81951 -5.82554  -23.74344 1.000 41.54907 ? 735 HOH   A O   1 
HETATM 5328 O  O   . HOH   I 5 .   ? -17.31463 -1.27662  -31.32471 1.000 8.91278  ? 736 HOH   A O   1 
HETATM 5329 O  O   . HOH   I 5 .   ? 4.90427   21.00231  -39.66862 1.000 17.92872 ? 737 HOH   A O   1 
HETATM 5330 O  O   . HOH   I 5 .   ? -32.25913 -1.77035  -32.23460 1.000 21.29233 ? 738 HOH   A O   1 
HETATM 5331 O  O   . HOH   I 5 .   ? -18.53406 0.35286   -43.80170 1.000 22.39443 ? 739 HOH   A O   1 
HETATM 5332 O  O   . HOH   I 5 .   ? -22.17180 4.12672   -33.27192 1.000 8.62860  ? 740 HOH   A O   1 
HETATM 5333 O  O   . HOH   I 5 .   ? -23.36263 -19.72193 -15.01223 1.000 31.65072 ? 741 HOH   A O   1 
HETATM 5334 O  O   . HOH   I 5 .   ? -20.16985 2.62050   -44.78037 1.000 25.78909 ? 742 HOH   A O   1 
HETATM 5335 O  O   . HOH   I 5 .   ? -19.60343 6.10386   -46.43606 1.000 18.59590 ? 743 HOH   A O   1 
HETATM 5336 O  O   . HOH   I 5 .   ? 2.17715   22.79813  -28.19656 1.000 23.71705 ? 744 HOH   A O   1 
HETATM 5337 O  O   . HOH   I 5 .   ? 0.27747   -10.24098 -16.98417 1.000 29.79042 ? 745 HOH   A O   1 
HETATM 5338 O  O   . HOH   I 5 .   ? -2.93067  -21.34786 -31.54925 1.000 28.21732 ? 746 HOH   A O   1 
HETATM 5339 O  O   . HOH   I 5 .   ? -13.02278 1.87562   -44.30188 1.000 17.43158 ? 747 HOH   A O   1 
HETATM 5340 O  O   . HOH   I 5 .   ? -28.88304 6.71876   -16.44669 1.000 25.86276 ? 748 HOH   A O   1 
HETATM 5341 O  O   . HOH   I 5 .   ? 6.58421   -2.86978  -43.00745 1.000 41.39982 ? 749 HOH   A O   1 
HETATM 5342 O  O   . HOH   I 5 .   ? -17.73509 4.60370   -45.42752 1.000 23.62373 ? 750 HOH   A O   1 
HETATM 5343 O  O   . HOH   I 5 .   ? -0.63798  19.83538  -35.91309 1.000 16.97151 ? 751 HOH   A O   1 
HETATM 5344 O  O   . HOH   I 5 .   ? -20.80609 2.32486   -27.87360 1.000 8.40491  ? 752 HOH   A O   1 
HETATM 5345 O  O   . HOH   I 5 .   ? -9.56820  7.88634   -11.12687 1.000 26.10856 ? 753 HOH   A O   1 
HETATM 5346 O  O   . HOH   I 5 .   ? -12.08912 1.57826   -10.03452 1.000 28.59329 ? 754 HOH   A O   1 
HETATM 5347 O  O   . HOH   I 5 .   ? -8.48447  24.33501  -13.85582 1.000 33.16066 ? 755 HOH   A O   1 
HETATM 5348 O  O   . HOH   I 5 .   ? -26.25080 0.36204   -33.75109 1.000 11.72074 ? 756 HOH   A O   1 
HETATM 5349 O  O   . HOH   I 5 .   ? -33.90493 3.27700   -44.25941 1.000 18.87481 ? 757 HOH   A O   1 
HETATM 5350 O  O   . HOH   I 5 .   ? -34.41481 7.87614   -27.74154 1.000 19.12903 ? 758 HOH   A O   1 
HETATM 5351 O  O   . HOH   I 5 .   ? -21.49192 -9.12066  -35.46177 1.000 24.71976 ? 759 HOH   A O   1 
HETATM 5352 O  O   . HOH   I 5 .   ? -1.25867  1.93545   -19.23807 1.000 19.77194 ? 760 HOH   A O   1 
HETATM 5353 O  O   . HOH   I 5 .   ? -39.12047 8.25549   -32.71319 1.000 39.71735 ? 761 HOH   A O   1 
HETATM 5354 O  O   . HOH   I 5 .   ? -23.17900 -1.55713  -48.02245 1.000 17.56400 ? 762 HOH   A O   1 
HETATM 5355 O  O   . HOH   I 5 .   ? -17.76119 -17.02798 -23.37422 1.000 28.55696 ? 763 HOH   A O   1 
HETATM 5356 O  O   . HOH   I 5 .   ? -23.18370 -0.34439  -34.41319 1.000 20.47416 ? 764 HOH   A O   1 
HETATM 5357 O  O   . HOH   I 5 .   ? -28.67580 -5.70682  -19.61792 1.000 20.30299 ? 765 HOH   A O   1 
HETATM 5358 O  O   . HOH   I 5 .   ? -17.02525 17.75960  -8.06244  1.000 40.95720 ? 766 HOH   A O   1 
HETATM 5359 O  O   . HOH   I 5 .   ? -14.08728 21.48521  -22.23106 1.000 35.30390 ? 767 HOH   A O   1 
HETATM 5360 O  O   . HOH   I 5 .   ? -20.49756 -12.14687 -39.48495 1.000 28.29912 ? 768 HOH   A O   1 
HETATM 5361 O  O   . HOH   I 5 .   ? -12.78241 -8.57061  -9.64060  1.000 33.35166 ? 769 HOH   A O   1 
HETATM 5362 O  O   . HOH   I 5 .   ? 1.27852   24.89012  -27.31209 1.000 33.09829 ? 770 HOH   A O   1 
HETATM 5363 O  O   . HOH   I 5 .   ? -24.30450 17.51992  -31.26144 1.000 13.28949 ? 771 HOH   A O   1 
HETATM 5364 O  O   . HOH   I 5 .   ? -26.39856 -16.69136 -6.19663  1.000 29.82140 ? 772 HOH   A O   1 
HETATM 5365 O  O   . HOH   I 5 .   ? -4.04606  -0.76994  -15.14170 1.000 22.72710 ? 773 HOH   A O   1 
HETATM 5366 O  O   . HOH   I 5 .   ? 5.06106   3.23421   -29.60473 1.000 30.32833 ? 774 HOH   A O   1 
HETATM 5367 O  O   . HOH   I 5 .   ? -12.72092 0.24516   -33.36730 1.000 21.17526 ? 775 HOH   A O   1 
HETATM 5368 O  O   . HOH   I 5 .   ? -13.00222 28.30615  -39.39275 1.000 32.54686 ? 776 HOH   A O   1 
HETATM 5369 O  O   . HOH   I 5 .   ? 5.69182   -4.94797  -35.26200 1.000 25.32018 ? 777 HOH   A O   1 
HETATM 5370 O  O   . HOH   I 5 .   ? -5.10335  30.89224  -27.82928 1.000 43.16384 ? 778 HOH   A O   1 
HETATM 5371 O  O   . HOH   I 5 .   ? 4.42308   17.13862  -38.27039 1.000 29.99965 ? 779 HOH   A O   1 
HETATM 5372 O  O   . HOH   I 5 .   ? -4.90042  9.08149   -7.72756  1.000 32.20183 ? 780 HOH   A O   1 
HETATM 5373 O  O   . HOH   I 5 .   ? -19.93263 -9.53865  -38.38184 1.000 21.31224 ? 781 HOH   A O   1 
HETATM 5374 O  O   . HOH   I 5 .   ? 2.56485   -11.58077 -26.42226 1.000 29.56871 ? 782 HOH   A O   1 
HETATM 5375 O  O   . HOH   I 5 .   ? -19.57312 23.81404  -29.85637 1.000 23.69759 ? 783 HOH   A O   1 
HETATM 5376 O  O   . HOH   I 5 .   ? -26.34672 0.82950   -40.39079 1.000 10.79053 ? 784 HOH   A O   1 
HETATM 5377 O  O   . HOH   I 5 .   ? -24.67428 2.36116   -31.64609 1.000 12.21093 ? 785 HOH   A O   1 
HETATM 5378 O  O   . HOH   I 5 .   ? -30.85600 8.24428   -23.58875 1.000 17.66226 ? 786 HOH   A O   1 
HETATM 5379 O  O   . HOH   I 5 .   ? -6.02019  -11.69693 -40.02949 1.000 24.82729 ? 787 HOH   A O   1 
HETATM 5380 O  O   . HOH   I 5 .   ? -22.30485 2.95526   -30.62977 1.000 9.27138  ? 788 HOH   A O   1 
HETATM 5381 O  O   . HOH   I 5 .   ? 6.17459   9.88053   -22.33744 1.000 41.45378 ? 789 HOH   A O   1 
HETATM 5382 O  O   . HOH   I 5 .   ? -28.48116 -18.07009 -16.77371 1.000 35.85956 ? 790 HOH   A O   1 
HETATM 5383 O  O   . HOH   I 5 .   ? -32.54407 -10.68395 -15.57792 1.000 30.79011 ? 791 HOH   A O   1 
HETATM 5384 O  O   . HOH   I 5 .   ? -41.29591 -6.98288  -29.07373 1.000 45.81443 ? 792 HOH   A O   1 
HETATM 5385 O  O   . HOH   I 5 .   ? 4.67998   8.46256   -36.83006 1.000 21.96859 ? 793 HOH   A O   1 
HETATM 5386 O  O   . HOH   I 5 .   ? 1.70603   -1.89581  -45.76924 1.000 26.06059 ? 794 HOH   A O   1 
HETATM 5387 O  O   . HOH   I 5 .   ? -34.41878 -6.34632  -15.01477 1.000 26.65281 ? 795 HOH   A O   1 
HETATM 5388 O  O   . HOH   I 5 .   ? -22.66623 1.52676   -9.26515  1.000 20.05799 ? 796 HOH   A O   1 
HETATM 5389 O  O   . HOH   I 5 .   ? -0.79106  -0.59827  -20.02456 1.000 28.30280 ? 797 HOH   A O   1 
HETATM 5390 O  O   . HOH   I 5 .   ? -40.92834 7.53755   -40.57420 1.000 35.51257 ? 798 HOH   A O   1 
HETATM 5391 O  O   . HOH   I 5 .   ? -31.61597 11.24977  -38.74752 1.000 20.23802 ? 799 HOH   A O   1 
HETATM 5392 O  O   . HOH   I 5 .   ? -43.70901 -5.17688  -29.92339 1.000 42.55647 ? 800 HOH   A O   1 
HETATM 5393 O  O   . HOH   I 5 .   ? -27.87221 13.17915  -33.77953 1.000 22.37700 ? 801 HOH   A O   1 
HETATM 5394 O  O   . HOH   I 5 .   ? -22.90806 9.57720   -12.86551 1.000 25.60248 ? 802 HOH   A O   1 
HETATM 5395 O  O   . HOH   I 5 .   ? -36.31134 3.21346   -46.22984 1.000 28.00745 ? 803 HOH   A O   1 
HETATM 5396 O  O   . HOH   I 5 .   ? 1.77673   -7.96970  -18.26312 1.000 29.54505 ? 804 HOH   A O   1 
HETATM 5397 O  O   . HOH   I 5 .   ? 7.10414   -16.03395 -33.66286 1.000 24.60588 ? 805 HOH   A O   1 
HETATM 5398 O  O   . HOH   I 5 .   ? -12.37853 21.52164  -17.01294 1.000 27.09780 ? 806 HOH   A O   1 
HETATM 5399 O  O   . HOH   I 5 .   ? 3.15906   1.17381   -29.24045 1.000 20.30187 ? 807 HOH   A O   1 
HETATM 5400 O  O   . HOH   I 5 .   ? 11.35102  -12.99240 -26.96050 1.000 40.31394 ? 808 HOH   A O   1 
HETATM 5401 O  O   . HOH   I 5 .   ? 2.55791   5.49739   -39.74425 1.000 16.96319 ? 809 HOH   A O   1 
HETATM 5402 O  O   . HOH   I 5 .   ? 2.08851   3.49164   -16.43990 1.000 38.08446 ? 810 HOH   A O   1 
HETATM 5403 O  O   . HOH   I 5 .   ? -20.77320 10.85825  -13.60513 1.000 34.56442 ? 811 HOH   A O   1 
HETATM 5404 O  O   . HOH   I 5 .   ? -33.85168 -12.48988 -7.99103  1.000 45.88994 ? 812 HOH   A O   1 
HETATM 5405 O  O   . HOH   I 5 .   ? -17.12442 25.33921  -41.13620 1.000 35.60203 ? 813 HOH   A O   1 
HETATM 5406 O  O   . HOH   I 5 .   ? -7.15488  -17.72338 -15.41434 1.000 37.92019 ? 814 HOH   A O   1 
HETATM 5407 O  O   . HOH   I 5 .   ? -16.68319 -16.33445 -15.77094 1.000 26.11568 ? 815 HOH   A O   1 
HETATM 5408 O  O   . HOH   I 5 .   ? 0.41689   5.24528   -9.61240  1.000 45.22042 ? 816 HOH   A O   1 
HETATM 5409 O  O   . HOH   I 5 .   ? 9.34648   17.90954  -25.10249 1.000 31.11907 ? 817 HOH   A O   1 
HETATM 5410 O  O   . HOH   I 5 .   ? -0.90042  2.18368   -13.98310 1.000 35.22037 ? 818 HOH   A O   1 
HETATM 5411 O  O   . HOH   I 5 .   ? -6.705    15.670    -2.655    1.000 47.69134 ? 819 HOH   A O   1 
HETATM 5412 O  O   . HOH   I 5 .   ? -37.88578 -6.95056  -25.36928 1.000 38.19253 ? 820 HOH   A O   1 
HETATM 5413 O  O   . HOH   I 5 .   ? -17.90738 -7.28260  -41.74987 1.000 26.68034 ? 821 HOH   A O   1 
HETATM 5414 O  O   . HOH   I 5 .   ? 4.60555   9.94392   -39.24659 1.000 25.96384 ? 822 HOH   A O   1 
HETATM 5415 O  O   . HOH   I 5 .   ? 4.26129   -1.39271  -41.88429 1.000 37.14969 ? 823 HOH   A O   1 
HETATM 5416 O  O   . HOH   I 5 .   ? -14.21055 -17.11833 -28.17606 1.000 34.10372 ? 824 HOH   A O   1 
HETATM 5417 O  O   . HOH   I 5 .   ? -15.99057 -18.86647 -24.40107 1.000 38.25101 ? 825 HOH   A O   1 
HETATM 5418 O  O   . HOH   I 5 .   ? -0.32376  23.32296  -21.00374 1.000 34.44892 ? 826 HOH   A O   1 
HETATM 5419 O  O   . HOH   I 5 .   ? -9.82752  22.27477  -2.77297  1.000 40.23144 ? 827 HOH   A O   1 
HETATM 5420 O  O   . HOH   I 5 .   ? -1.74248  7.00273   -46.75053 1.000 26.54633 ? 828 HOH   A O   1 
HETATM 5421 O  O   . HOH   I 5 .   ? -33.154   16.547    -22.036   1.000 43.94638 ? 829 HOH   A O   1 
HETATM 5422 O  O   . HOH   I 5 .   ? -7.27636  -12.35823 -41.94792 1.000 34.30105 ? 830 HOH   A O   1 
HETATM 5423 O  O   . HOH   I 5 .   ? -26.10032 -6.36510  -26.57035 1.000 36.09874 ? 831 HOH   A O   1 
HETATM 5424 O  O   . HOH   I 5 .   ? -7.45956  31.36034  -28.75532 1.000 29.64424 ? 832 HOH   A O   1 
HETATM 5425 O  O   . HOH   I 5 .   ? -30.48842 -2.24846  -11.64406 1.000 25.40583 ? 833 HOH   A O   1 
HETATM 5426 O  O   . HOH   I 5 .   ? -6.19275  19.84251  -13.58125 1.000 35.00986 ? 834 HOH   A O   1 
HETATM 5427 O  O   . HOH   I 5 .   ? 3.38927   -11.18968 -40.13465 1.000 27.81515 ? 835 HOH   A O   1 
HETATM 5428 O  O   . HOH   I 5 .   ? -8.03090  -4.21223  -13.05212 1.000 34.02218 ? 836 HOH   A O   1 
HETATM 5429 O  O   . HOH   I 5 .   ? -6.77843  -10.24142 -43.18269 1.000 36.26290 ? 837 HOH   A O   1 
HETATM 5430 O  O   . HOH   I 5 .   ? -0.59381  16.81127  -3.30453  1.000 37.56013 ? 838 HOH   A O   1 
HETATM 5431 O  O   . HOH   I 5 .   ? -25.20912 -8.61570  -36.77187 1.000 33.25507 ? 839 HOH   A O   1 
HETATM 5432 O  O   . HOH   I 5 .   ? -5.41192  3.48433   -50.47358 1.000 32.04480 ? 840 HOH   A O   1 
HETATM 5433 O  O   . HOH   I 5 .   ? -42.271   -12.099   -17.929   1.000 39.37748 ? 841 HOH   A O   1 
HETATM 5434 O  O   . HOH   I 5 .   ? -26.72469 -7.10889  -37.97488 1.000 38.42376 ? 842 HOH   A O   1 
HETATM 5435 O  O   . HOH   I 5 .   ? -14.11907 18.16033  -4.98662  1.000 36.93921 ? 843 HOH   A O   1 
HETATM 5436 O  O   . HOH   I 5 .   ? -32.23898 16.07591  -40.63188 1.000 34.95323 ? 844 HOH   A O   1 
HETATM 5437 O  O   . HOH   I 5 .   ? -1.12402  28.25981  -23.61647 1.000 42.73809 ? 845 HOH   A O   1 
HETATM 5438 O  O   . HOH   I 5 .   ? -34.34094 17.18199  -40.60287 1.000 33.40468 ? 846 HOH   A O   1 
HETATM 5439 O  O   . HOH   I 5 .   ? 1.54348   32.07305  -26.44983 1.000 32.11919 ? 847 HOH   A O   1 
HETATM 5440 O  O   . HOH   J 5 .   ? -27.30913 -31.41185 -68.74038 1.000 52.27146 ? 701 HOH   B O   1 
HETATM 5441 O  O   . HOH   J 5 .   ? -32.08477 -13.83140 -53.65987 1.000 39.00425 ? 702 HOH   B O   1 
HETATM 5442 O  O   . HOH   J 5 .   ? -8.12801  -7.30396  -73.35313 1.000 24.11558 ? 703 HOH   B O   1 
HETATM 5443 O  O   . HOH   J 5 .   ? -8.38749  21.76403  -52.68309 1.000 53.55028 ? 704 HOH   B O   1 
HETATM 5444 O  O   . HOH   J 5 .   ? -22.52191 5.50213   -60.28697 1.000 12.64466 ? 705 HOH   B O   1 
HETATM 5445 O  O   . HOH   J 5 .   ? -7.76460  6.86149   -57.38453 1.000 25.82909 ? 706 HOH   B O   1 
HETATM 5446 O  O   . HOH   J 5 .   ? -10.98591 -5.45841  -66.16069 1.000 25.66930 ? 707 HOH   B O   1 
HETATM 5447 O  O   . HOH   J 5 .   ? -19.70462 0.91838   -63.02762 1.000 16.37769 ? 708 HOH   B O   1 
HETATM 5448 O  O   . HOH   J 5 .   ? -46.42855 1.68747   -56.10577 1.000 37.33226 ? 709 HOH   B O   1 
HETATM 5449 O  O   . HOH   J 5 .   ? -17.70602 21.03536  -71.25678 1.000 64.63788 ? 710 HOH   B O   1 
HETATM 5450 O  O   . HOH   J 5 .   ? -14.89298 12.32328  -43.44957 1.000 10.83329 ? 711 HOH   B O   1 
HETATM 5451 O  O   . HOH   J 5 .   ? -13.83221 13.28518  -64.48145 1.000 22.91289 ? 712 HOH   B O   1 
HETATM 5452 O  O   . HOH   J 5 .   ? -14.76200 8.04295   -59.90079 1.000 13.13425 ? 713 HOH   B O   1 
HETATM 5453 O  O   . HOH   J 5 .   ? -49.16018 -6.23356  -64.49242 1.000 39.19428 ? 714 HOH   B O   1 
HETATM 5454 O  O   . HOH   J 5 .   ? -21.54688 5.17449   -63.17457 1.000 11.18189 ? 715 HOH   B O   1 
HETATM 5455 O  O   . HOH   J 5 .   ? -39.04291 19.46959  -49.68924 1.000 37.80408 ? 716 HOH   B O   1 
HETATM 5456 O  O   . HOH   J 5 .   ? -23.59912 6.32634   -71.94275 1.000 16.95885 ? 717 HOH   B O   1 
HETATM 5457 O  O   . HOH   J 5 .   ? -15.39435 17.89752  -65.63183 1.000 23.40704 ? 718 HOH   B O   1 
HETATM 5458 O  O   . HOH   J 5 .   ? -13.98088 19.83288  -54.80267 1.000 21.84862 ? 719 HOH   B O   1 
HETATM 5459 O  O   . HOH   J 5 .   ? -16.04480 12.54756  -64.40871 1.000 22.87157 ? 720 HOH   B O   1 
HETATM 5460 O  O   . HOH   J 5 .   ? -34.745   -26.979   -69.654   1.000 46.85116 ? 721 HOH   B O   1 
HETATM 5461 O  O   . HOH   J 5 .   ? -9.27110  8.15768   -46.57152 1.000 13.18059 ? 722 HOH   B O   1 
HETATM 5462 O  O   . HOH   J 5 .   ? -20.28622 6.44177   -65.71530 1.000 10.63822 ? 723 HOH   B O   1 
HETATM 5463 O  O   . HOH   J 5 .   ? -36.45016 -10.23970 -52.26877 1.000 37.61448 ? 724 HOH   B O   1 
HETATM 5464 O  O   . HOH   J 5 .   ? -51.09287 4.29496   -63.26313 1.000 41.37689 ? 725 HOH   B O   1 
HETATM 5465 O  O   . HOH   J 5 .   ? -14.08015 5.63872   -57.29717 1.000 16.98926 ? 726 HOH   B O   1 
HETATM 5466 O  O   . HOH   J 5 .   ? -5.97845  12.86397  -78.64712 1.000 33.41416 ? 727 HOH   B O   1 
HETATM 5467 O  O   . HOH   J 5 .   ? -24.92318 15.12081  -63.18821 1.000 13.43088 ? 728 HOH   B O   1 
HETATM 5468 O  O   . HOH   J 5 .   ? -33.22994 -2.91117  -46.91499 1.000 22.03353 ? 729 HOH   B O   1 
HETATM 5469 O  O   . HOH   J 5 .   ? -28.22938 -19.76090 -71.38757 1.000 50.99522 ? 730 HOH   B O   1 
HETATM 5470 O  O   . HOH   J 5 .   ? -16.53049 1.96399   -50.62695 1.000 28.87296 ? 731 HOH   B O   1 
HETATM 5471 O  O   . HOH   J 5 .   ? -20.46913 7.74299   -59.98800 1.000 5.82530  ? 732 HOH   B O   1 
HETATM 5472 O  O   . HOH   J 5 .   ? -41.82483 1.68383   -88.28528 1.000 54.10329 ? 733 HOH   B O   1 
HETATM 5473 O  O   . HOH   J 5 .   ? -19.15226 0.78626   -50.68456 1.000 21.91694 ? 734 HOH   B O   1 
HETATM 5474 O  O   . HOH   J 5 .   ? -19.61107 5.25534   -60.93725 1.000 11.96392 ? 735 HOH   B O   1 
HETATM 5475 O  O   . HOH   J 5 .   ? -14.26557 4.54427   -53.62037 1.000 16.46054 ? 736 HOH   B O   1 
HETATM 5476 O  O   . HOH   J 5 .   ? -19.69480 5.27450   -67.97812 1.000 21.78753 ? 737 HOH   B O   1 
HETATM 5477 O  O   . HOH   J 5 .   ? -11.34510 21.95650  -71.29779 1.000 36.24736 ? 738 HOH   B O   1 
HETATM 5478 O  O   . HOH   J 5 .   ? -14.74012 7.25562   -53.00859 1.000 17.05593 ? 739 HOH   B O   1 
HETATM 5479 O  O   . HOH   J 5 .   ? -18.44228 18.59137  -68.27931 1.000 29.04285 ? 740 HOH   B O   1 
HETATM 5480 O  O   . HOH   J 5 .   ? -17.43378 -1.44614  -60.52000 1.000 12.94601 ? 741 HOH   B O   1 
HETATM 5481 O  O   . HOH   J 5 .   ? -13.83490 5.55339   -90.69881 1.000 16.66166 ? 742 HOH   B O   1 
HETATM 5482 O  O   . HOH   J 5 .   ? -50.32091 3.89594   -70.96244 1.000 47.49247 ? 743 HOH   B O   1 
HETATM 5483 O  O   . HOH   J 5 .   ? -26.663   -21.666   -58.353   1.000 33.75969 ? 744 HOH   B O   1 
HETATM 5484 O  O   . HOH   J 5 .   ? -33.49267 -7.72245  -75.13919 1.000 38.66835 ? 745 HOH   B O   1 
HETATM 5485 O  O   . HOH   J 5 .   ? -35.84901 17.25201  -45.72780 1.000 39.59396 ? 746 HOH   B O   1 
HETATM 5486 O  O   . HOH   J 5 .   ? -3.41468  -1.40833  -75.46680 1.000 35.36747 ? 747 HOH   B O   1 
HETATM 5487 O  O   . HOH   J 5 .   ? -6.06414  12.26107  -50.89447 1.000 32.47939 ? 748 HOH   B O   1 
HETATM 5488 O  O   . HOH   J 5 .   ? -19.18846 2.98569   -71.18400 1.000 16.50601 ? 749 HOH   B O   1 
HETATM 5489 O  O   . HOH   J 5 .   ? -48.69248 9.99891   -54.29440 1.000 41.97775 ? 750 HOH   B O   1 
HETATM 5490 O  O   . HOH   J 5 .   ? -38.81221 -2.26468  -43.44311 1.000 42.27544 ? 751 HOH   B O   1 
HETATM 5491 O  O   . HOH   J 5 .   ? -17.32816 25.62020  -59.73822 1.000 35.98892 ? 752 HOH   B O   1 
HETATM 5492 O  O   . HOH   J 5 .   ? -47.15844 16.35974  -60.31045 1.000 37.17717 ? 753 HOH   B O   1 
HETATM 5493 O  O   . HOH   J 5 .   ? -40.36166 3.73867   -90.98893 1.000 43.18271 ? 754 HOH   B O   1 
HETATM 5494 O  O   . HOH   J 5 .   ? -37.26272 7.56361   -49.09828 1.000 26.37751 ? 755 HOH   B O   1 
HETATM 5495 O  O   . HOH   J 5 .   ? -7.96444  -4.66037  -83.09476 1.000 25.33315 ? 756 HOH   B O   1 
HETATM 5496 O  O   . HOH   J 5 .   ? -19.61985 3.02648   -49.12995 1.000 23.74441 ? 757 HOH   B O   1 
HETATM 5497 O  O   . HOH   J 5 .   ? -11.74210 8.29306   -58.73574 1.000 16.34859 ? 758 HOH   B O   1 
HETATM 5498 O  O   . HOH   J 5 .   ? -3.54194  1.66671   -79.14031 1.000 30.10760 ? 759 HOH   B O   1 
HETATM 5499 O  O   . HOH   J 5 .   ? -44.20289 8.39540   -65.98231 1.000 39.79624 ? 760 HOH   B O   1 
HETATM 5500 O  O   . HOH   J 5 .   ? -50.71190 18.63556  -52.67542 1.000 36.37157 ? 761 HOH   B O   1 
HETATM 5501 O  O   . HOH   J 5 .   ? -6.67348  -1.66846  -86.41296 1.000 28.97694 ? 762 HOH   B O   1 
HETATM 5502 O  O   . HOH   J 5 .   ? -14.30785 0.54689   -53.43079 1.000 29.86264 ? 763 HOH   B O   1 
HETATM 5503 O  O   . HOH   J 5 .   ? -43.15608 12.56090  -48.26926 1.000 36.09099 ? 764 HOH   B O   1 
HETATM 5504 O  O   . HOH   J 5 .   ? 1.44271   18.49569  -59.13001 1.000 39.72168 ? 765 HOH   B O   1 
HETATM 5505 O  O   . HOH   J 5 .   ? -10.24967 13.22644  -81.61626 1.000 29.47647 ? 766 HOH   B O   1 
HETATM 5506 O  O   . HOH   J 5 .   ? -53.09415 8.46111   -59.60539 1.000 42.63102 ? 767 HOH   B O   1 
HETATM 5507 O  O   . HOH   J 5 .   ? -28.71033 9.29592   -81.45868 1.000 32.48847 ? 768 HOH   B O   1 
HETATM 5508 O  O   . HOH   J 5 .   ? -18.57332 18.12636  -52.58957 1.000 25.85816 ? 769 HOH   B O   1 
HETATM 5509 O  O   . HOH   J 5 .   ? -16.20757 5.64058   -59.86316 1.000 23.85578 ? 770 HOH   B O   1 
HETATM 5510 O  O   . HOH   J 5 .   ? -19.72268 7.50082   -62.65474 1.000 9.08995  ? 771 HOH   B O   1 
HETATM 5511 O  O   . HOH   J 5 .   ? -22.39984 4.67974   -46.52201 1.000 21.92473 ? 772 HOH   B O   1 
HETATM 5512 O  O   . HOH   J 5 .   ? -11.39411 14.09944  -48.28305 1.000 18.34037 ? 773 HOH   B O   1 
HETATM 5513 O  O   . HOH   J 5 .   ? -19.85068 -7.08489  -68.04037 1.000 26.85144 ? 774 HOH   B O   1 
HETATM 5514 O  O   . HOH   J 5 .   ? -42.23684 1.90080   -46.09418 1.000 38.63099 ? 775 HOH   B O   1 
HETATM 5515 O  O   . HOH   J 5 .   ? -22.46677 -3.01452  -53.00966 1.000 26.36850 ? 776 HOH   B O   1 
HETATM 5516 O  O   . HOH   J 5 .   ? -34.185   -18.216   -54.734   1.000 35.59583 ? 777 HOH   B O   1 
HETATM 5517 O  O   . HOH   J 5 .   ? -29.62499 -16.28098 -50.13939 1.000 35.99856 ? 778 HOH   B O   1 
HETATM 5518 O  O   . HOH   J 5 .   ? -33.00641 13.75724  -84.95362 1.000 41.91007 ? 779 HOH   B O   1 
HETATM 5519 O  O   . HOH   J 5 .   ? -8.62476  -8.43822  -57.48406 1.000 29.04094 ? 780 HOH   B O   1 
HETATM 5520 O  O   . HOH   J 5 .   ? -30.96318 1.16450   -83.85592 1.000 35.70423 ? 781 HOH   B O   1 
HETATM 5521 O  O   . HOH   J 5 .   ? -21.57926 1.79353   -86.61298 1.000 31.99588 ? 782 HOH   B O   1 
HETATM 5522 O  O   . HOH   J 5 .   ? -46.20820 10.54673  -53.38732 1.000 32.27351 ? 783 HOH   B O   1 
HETATM 5523 O  O   . HOH   J 5 .   ? 2.95702   3.16559   -77.64800 1.000 40.69179 ? 784 HOH   B O   1 
HETATM 5524 O  O   . HOH   J 5 .   ? -25.20844 21.83008  -60.38502 1.000 29.02725 ? 785 HOH   B O   1 
HETATM 5525 O  O   . HOH   J 5 .   ? -28.68515 -9.66697  -74.88297 1.000 23.83680 ? 786 HOH   B O   1 
HETATM 5526 O  O   . HOH   J 5 .   ? 0.88716   15.06235  -63.63711 1.000 53.58418 ? 787 HOH   B O   1 
HETATM 5527 O  O   . HOH   J 5 .   ? -4.63347  0.06405   -87.16154 1.000 26.23009 ? 788 HOH   B O   1 
HETATM 5528 O  O   . HOH   J 5 .   ? -22.85558 -16.57106 -81.56474 1.000 46.69399 ? 789 HOH   B O   1 
HETATM 5529 O  O   . HOH   J 5 .   ? -24.09415 10.90385  -81.41372 1.000 29.35689 ? 790 HOH   B O   1 
HETATM 5530 O  O   . HOH   J 5 .   ? -28.78741 -19.12276 -74.23945 1.000 36.79803 ? 791 HOH   B O   1 
HETATM 5531 O  O   . HOH   J 5 .   ? -36.69979 -7.44208  -47.49710 1.000 37.39469 ? 792 HOH   B O   1 
HETATM 5532 O  O   . HOH   J 5 .   ? -6.60767  6.35918   -52.71005 1.000 32.51756 ? 793 HOH   B O   1 
HETATM 5533 O  O   . HOH   J 5 .   ? -30.07754 -11.22177 -77.39078 1.000 36.39017 ? 794 HOH   B O   1 
HETATM 5534 O  O   . HOH   J 5 .   ? -15.17787 12.51086  -83.05602 1.000 40.45111 ? 795 HOH   B O   1 
HETATM 5535 O  O   . HOH   J 5 .   ? -7.13725  -7.60210  -86.47317 1.000 40.51581 ? 796 HOH   B O   1 
HETATM 5536 O  O   . HOH   J 5 .   ? -32.79483 -4.91429  -45.86234 1.000 31.55300 ? 797 HOH   B O   1 
HETATM 5537 O  O   . HOH   J 5 .   ? -36.65267 -11.03658 -54.98941 1.000 40.77139 ? 798 HOH   B O   1 
HETATM 5538 O  O   . HOH   J 5 .   ? -27.63662 17.42449  -71.15066 1.000 32.19382 ? 799 HOH   B O   1 
HETATM 5539 O  O   . HOH   J 5 .   ? -40.85970 13.14078  -46.25274 1.000 33.11144 ? 800 HOH   B O   1 
HETATM 5540 O  O   . HOH   J 5 .   ? -7.20975  8.09137   -51.19499 1.000 32.14531 ? 801 HOH   B O   1 
HETATM 5541 O  O   . HOH   J 5 .   ? -43.95442 11.17441  -70.68747 1.000 47.71075 ? 802 HOH   B O   1 
HETATM 5542 O  O   . HOH   J 5 .   ? -10.67928 9.35464   -64.43000 1.000 41.94023 ? 803 HOH   B O   1 
HETATM 5543 O  O   . HOH   J 5 .   ? -11.43004 16.61847  -45.68908 1.000 28.13071 ? 804 HOH   B O   1 
HETATM 5544 O  O   . HOH   J 5 .   ? -35.96970 5.18327   -48.47771 1.000 29.81083 ? 805 HOH   B O   1 
HETATM 5545 O  O   . HOH   J 5 .   ? -7.64316  2.19429   -69.23424 1.000 37.64417 ? 806 HOH   B O   1 
HETATM 5546 O  O   . HOH   J 5 .   ? -34.02648 16.07785  -84.36957 1.000 41.37012 ? 807 HOH   B O   1 
HETATM 5547 O  O   . HOH   J 5 .   ? -20.74393 16.67225  -43.23139 1.000 31.86032 ? 808 HOH   B O   1 
HETATM 5548 O  O   . HOH   J 5 .   ? -10.73185 -6.93879  -79.16687 1.000 27.00067 ? 809 HOH   B O   1 
HETATM 5549 O  O   . HOH   J 5 .   ? -6.62085  -3.69468  -88.74451 1.000 23.24673 ? 810 HOH   B O   1 
HETATM 5550 O  O   . HOH   J 5 .   ? -6.20425  -4.06722  -84.74512 1.000 41.32131 ? 811 HOH   B O   1 
HETATM 5551 O  O   . HOH   J 5 .   ? -50.28591 2.13641   -73.30391 1.000 37.66182 ? 812 HOH   B O   1 
HETATM 5552 O  O   . HOH   J 5 .   ? -35.116   -23.410   -71.838   1.000 38.95876 ? 813 HOH   B O   1 
HETATM 5553 O  O   . HOH   J 5 .   ? -18.58706 24.31102  -44.29706 1.000 49.96628 ? 814 HOH   B O   1 
HETATM 5554 O  O   . HOH   J 5 .   ? -39.03410 -9.89399  -51.28245 1.000 47.07759 ? 815 HOH   B O   1 
HETATM 5555 O  O   . HOH   J 5 .   ? -2.56802  25.40954  -76.15563 1.000 44.98537 ? 816 HOH   B O   1 
HETATM 5556 O  O   . HOH   J 5 .   ? -37.90847 2.72679   -50.59811 1.000 29.90865 ? 817 HOH   B O   1 
HETATM 5557 O  O   . HOH   J 5 .   ? -13.49764 2.92640   -51.49227 1.000 31.49207 ? 818 HOH   B O   1 
HETATM 5558 O  O   . HOH   J 5 .   ? -11.92503 -2.87647  -51.89594 1.000 45.99823 ? 819 HOH   B O   1 
HETATM 5559 O  O   . HOH   J 5 .   ? -38.23841 1.03692   -46.96195 1.000 33.28459 ? 820 HOH   B O   1 
HETATM 5560 O  O   . HOH   J 5 .   ? -7.75881  -9.30633  -71.18934 1.000 32.74836 ? 821 HOH   B O   1 
HETATM 5561 O  O   . HOH   J 5 .   ? -28.77249 -6.59203  -81.18069 1.000 41.63412 ? 822 HOH   B O   1 
HETATM 5562 O  O   . HOH   J 5 .   ? -8.89151  -9.53277  -59.96726 1.000 37.83661 ? 823 HOH   B O   1 
HETATM 5563 O  O   . HOH   J 5 .   ? -16.61527 5.19566   -90.52836 1.000 26.88803 ? 824 HOH   B O   1 
HETATM 5564 O  O   . HOH   J 5 .   ? -10.446   -18.325   -58.002   1.000 39.09072 ? 825 HOH   B O   1 
HETATM 5565 O  O   . HOH   J 5 .   ? -18.19343 -20.65567 -70.08658 1.000 39.65218 ? 826 HOH   B O   1 
HETATM 5566 O  O   . HOH   J 5 .   ? -29.88067 -7.25135  -78.77803 1.000 37.07398 ? 827 HOH   B O   1 
HETATM 5567 O  O   . HOH   J 5 .   ? -37.57705 -9.38537  -46.06251 1.000 45.46315 ? 828 HOH   B O   1 
HETATM 5568 O  O   . HOH   J 5 .   ? -26.89768 -10.03660 -48.62345 1.000 40.07178 ? 829 HOH   B O   1 
HETATM 5569 O  O   . HOH   J 5 .   ? -19.67776 -3.43406  -50.70506 1.000 34.56962 ? 830 HOH   B O   1 
HETATM 5570 O  O   . HOH   J 5 .   ? -19.89287 -1.54712  -48.80664 1.000 38.44728 ? 831 HOH   B O   1 
HETATM 5571 O  O   . HOH   J 5 .   ? -4.92367  -11.72453 -75.74314 1.000 33.78031 ? 832 HOH   B O   1 
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