data_9LNI
# 
_entry.id   9LNI 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9LNI         pdb_00009lni 10.2210/pdb9lni/pdb 
WWPDB D_1300056052 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-04 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9LNI 
_pdbx_database_status.recvd_initial_deposition_date   2025-01-21 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              hattori_fudan@outlook.com 
_pdbx_contact_author.name_first         Motoyuki 
_pdbx_contact_author.name_last          Hattori 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-5327-5337 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zhao, Z.'    1 ? 
'Hattori, M.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Crystal structure of the de novo designed protein ZZ1' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zhao, Z.'    1 ? 
primary 'Hattori, M.' 2 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man ZZ1        24952.260 1   ? ? ? ? 
2 non-polymer syn 'ZINC ION' 65.409    7   ? ? ? ? 
3 water       nat water      18.015    163 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SKEEILEQLEKMVEEAKEELKKAKDKSPLELILETLTLITLLSLLAIAKEDEETWKKLLEEALETAEETLKLVGLEELIE
EVKKEIKELFDELKKMIKEGESKEKIIIYNILKNFELEILLAMIEKGEKEEEIEKYRKKWEEKLKKYLEEVKTKEEALKI
LEEILKERKEELEKLGISKELVEKHLERIKKAAELVLSMGSLESSGLEVLFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SKEEILEQLEKMVEEAKEELKKAKDKSPLELILETLTLITLLSLLAIAKEDEETWKKLLEEALETAEETLKLVGLEELIE
EVKKEIKELFDELKKMIKEGESKEKIIIYNILKNFELEILLAMIEKGEKEEEIEKYRKKWEEKLKKYLEEVKTKEEALKI
LEEILKERKEELEKLGISKELVEKHLERIKKAAELVLSMGSLESSGLEVLFQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION' ZN  
3 water      HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   LYS n 
1 3   GLU n 
1 4   GLU n 
1 5   ILE n 
1 6   LEU n 
1 7   GLU n 
1 8   GLN n 
1 9   LEU n 
1 10  GLU n 
1 11  LYS n 
1 12  MET n 
1 13  VAL n 
1 14  GLU n 
1 15  GLU n 
1 16  ALA n 
1 17  LYS n 
1 18  GLU n 
1 19  GLU n 
1 20  LEU n 
1 21  LYS n 
1 22  LYS n 
1 23  ALA n 
1 24  LYS n 
1 25  ASP n 
1 26  LYS n 
1 27  SER n 
1 28  PRO n 
1 29  LEU n 
1 30  GLU n 
1 31  LEU n 
1 32  ILE n 
1 33  LEU n 
1 34  GLU n 
1 35  THR n 
1 36  LEU n 
1 37  THR n 
1 38  LEU n 
1 39  ILE n 
1 40  THR n 
1 41  LEU n 
1 42  LEU n 
1 43  SER n 
1 44  LEU n 
1 45  LEU n 
1 46  ALA n 
1 47  ILE n 
1 48  ALA n 
1 49  LYS n 
1 50  GLU n 
1 51  ASP n 
1 52  GLU n 
1 53  GLU n 
1 54  THR n 
1 55  TRP n 
1 56  LYS n 
1 57  LYS n 
1 58  LEU n 
1 59  LEU n 
1 60  GLU n 
1 61  GLU n 
1 62  ALA n 
1 63  LEU n 
1 64  GLU n 
1 65  THR n 
1 66  ALA n 
1 67  GLU n 
1 68  GLU n 
1 69  THR n 
1 70  LEU n 
1 71  LYS n 
1 72  LEU n 
1 73  VAL n 
1 74  GLY n 
1 75  LEU n 
1 76  GLU n 
1 77  GLU n 
1 78  LEU n 
1 79  ILE n 
1 80  GLU n 
1 81  GLU n 
1 82  VAL n 
1 83  LYS n 
1 84  LYS n 
1 85  GLU n 
1 86  ILE n 
1 87  LYS n 
1 88  GLU n 
1 89  LEU n 
1 90  PHE n 
1 91  ASP n 
1 92  GLU n 
1 93  LEU n 
1 94  LYS n 
1 95  LYS n 
1 96  MET n 
1 97  ILE n 
1 98  LYS n 
1 99  GLU n 
1 100 GLY n 
1 101 GLU n 
1 102 SER n 
1 103 LYS n 
1 104 GLU n 
1 105 LYS n 
1 106 ILE n 
1 107 ILE n 
1 108 ILE n 
1 109 TYR n 
1 110 ASN n 
1 111 ILE n 
1 112 LEU n 
1 113 LYS n 
1 114 ASN n 
1 115 PHE n 
1 116 GLU n 
1 117 LEU n 
1 118 GLU n 
1 119 ILE n 
1 120 LEU n 
1 121 LEU n 
1 122 ALA n 
1 123 MET n 
1 124 ILE n 
1 125 GLU n 
1 126 LYS n 
1 127 GLY n 
1 128 GLU n 
1 129 LYS n 
1 130 GLU n 
1 131 GLU n 
1 132 GLU n 
1 133 ILE n 
1 134 GLU n 
1 135 LYS n 
1 136 TYR n 
1 137 ARG n 
1 138 LYS n 
1 139 LYS n 
1 140 TRP n 
1 141 GLU n 
1 142 GLU n 
1 143 LYS n 
1 144 LEU n 
1 145 LYS n 
1 146 LYS n 
1 147 TYR n 
1 148 LEU n 
1 149 GLU n 
1 150 GLU n 
1 151 VAL n 
1 152 LYS n 
1 153 THR n 
1 154 LYS n 
1 155 GLU n 
1 156 GLU n 
1 157 ALA n 
1 158 LEU n 
1 159 LYS n 
1 160 ILE n 
1 161 LEU n 
1 162 GLU n 
1 163 GLU n 
1 164 ILE n 
1 165 LEU n 
1 166 LYS n 
1 167 GLU n 
1 168 ARG n 
1 169 LYS n 
1 170 GLU n 
1 171 GLU n 
1 172 LEU n 
1 173 GLU n 
1 174 LYS n 
1 175 LEU n 
1 176 GLY n 
1 177 ILE n 
1 178 SER n 
1 179 LYS n 
1 180 GLU n 
1 181 LEU n 
1 182 VAL n 
1 183 GLU n 
1 184 LYS n 
1 185 HIS n 
1 186 LEU n 
1 187 GLU n 
1 188 ARG n 
1 189 ILE n 
1 190 LYS n 
1 191 LYS n 
1 192 ALA n 
1 193 ALA n 
1 194 GLU n 
1 195 LEU n 
1 196 VAL n 
1 197 LEU n 
1 198 SER n 
1 199 MET n 
1 200 GLY n 
1 201 SER n 
1 202 LEU n 
1 203 GLU n 
1 204 SER n 
1 205 SER n 
1 206 GLY n 
1 207 LEU n 
1 208 GLU n 
1 209 VAL n 
1 210 LEU n 
1 211 PHE n 
1 212 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   212 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     562 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
ZN  non-polymer         . 'ZINC ION'      ? 'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   2   2   SER SER A . n 
A 1 2   LYS 2   3   3   LYS LYS A . n 
A 1 3   GLU 3   4   4   GLU GLU A . n 
A 1 4   GLU 4   5   5   GLU GLU A . n 
A 1 5   ILE 5   6   6   ILE ILE A . n 
A 1 6   LEU 6   7   7   LEU LEU A . n 
A 1 7   GLU 7   8   8   GLU GLU A . n 
A 1 8   GLN 8   9   9   GLN GLN A . n 
A 1 9   LEU 9   10  10  LEU LEU A . n 
A 1 10  GLU 10  11  11  GLU GLU A . n 
A 1 11  LYS 11  12  12  LYS LYS A . n 
A 1 12  MET 12  13  13  MET MET A . n 
A 1 13  VAL 13  14  14  VAL VAL A . n 
A 1 14  GLU 14  15  15  GLU GLU A . n 
A 1 15  GLU 15  16  16  GLU GLU A . n 
A 1 16  ALA 16  17  17  ALA ALA A . n 
A 1 17  LYS 17  18  18  LYS LYS A . n 
A 1 18  GLU 18  19  19  GLU GLU A . n 
A 1 19  GLU 19  20  20  GLU GLU A . n 
A 1 20  LEU 20  21  21  LEU LEU A . n 
A 1 21  LYS 21  22  22  LYS LYS A . n 
A 1 22  LYS 22  23  23  LYS LYS A . n 
A 1 23  ALA 23  24  24  ALA ALA A . n 
A 1 24  LYS 24  25  25  LYS LYS A . n 
A 1 25  ASP 25  26  26  ASP ASP A . n 
A 1 26  LYS 26  27  27  LYS LYS A . n 
A 1 27  SER 27  28  28  SER SER A . n 
A 1 28  PRO 28  29  29  PRO PRO A . n 
A 1 29  LEU 29  30  30  LEU LEU A . n 
A 1 30  GLU 30  31  31  GLU GLU A . n 
A 1 31  LEU 31  32  32  LEU LEU A . n 
A 1 32  ILE 32  33  33  ILE ILE A . n 
A 1 33  LEU 33  34  34  LEU LEU A . n 
A 1 34  GLU 34  35  35  GLU GLU A . n 
A 1 35  THR 35  36  36  THR THR A . n 
A 1 36  LEU 36  37  37  LEU LEU A . n 
A 1 37  THR 37  38  38  THR THR A . n 
A 1 38  LEU 38  39  39  LEU LEU A . n 
A 1 39  ILE 39  40  40  ILE ILE A . n 
A 1 40  THR 40  41  41  THR THR A . n 
A 1 41  LEU 41  42  42  LEU LEU A . n 
A 1 42  LEU 42  43  43  LEU LEU A . n 
A 1 43  SER 43  44  44  SER SER A . n 
A 1 44  LEU 44  45  45  LEU LEU A . n 
A 1 45  LEU 45  46  46  LEU LEU A . n 
A 1 46  ALA 46  47  47  ALA ALA A . n 
A 1 47  ILE 47  48  48  ILE ILE A . n 
A 1 48  ALA 48  49  49  ALA ALA A . n 
A 1 49  LYS 49  50  50  LYS LYS A . n 
A 1 50  GLU 50  51  51  GLU GLU A . n 
A 1 51  ASP 51  52  52  ASP ASP A . n 
A 1 52  GLU 52  53  53  GLU GLU A . n 
A 1 53  GLU 53  54  54  GLU GLU A . n 
A 1 54  THR 54  55  55  THR THR A . n 
A 1 55  TRP 55  56  56  TRP TRP A . n 
A 1 56  LYS 56  57  57  LYS LYS A . n 
A 1 57  LYS 57  58  58  LYS LYS A . n 
A 1 58  LEU 58  59  59  LEU LEU A . n 
A 1 59  LEU 59  60  60  LEU LEU A . n 
A 1 60  GLU 60  61  61  GLU GLU A . n 
A 1 61  GLU 61  62  62  GLU GLU A . n 
A 1 62  ALA 62  63  63  ALA ALA A . n 
A 1 63  LEU 63  64  64  LEU LEU A . n 
A 1 64  GLU 64  65  65  GLU GLU A . n 
A 1 65  THR 65  66  66  THR THR A . n 
A 1 66  ALA 66  67  67  ALA ALA A . n 
A 1 67  GLU 67  68  68  GLU GLU A . n 
A 1 68  GLU 68  69  69  GLU GLU A . n 
A 1 69  THR 69  70  70  THR THR A . n 
A 1 70  LEU 70  71  71  LEU LEU A . n 
A 1 71  LYS 71  72  72  LYS LYS A . n 
A 1 72  LEU 72  73  73  LEU LEU A . n 
A 1 73  VAL 73  74  74  VAL VAL A . n 
A 1 74  GLY 74  75  75  GLY GLY A . n 
A 1 75  LEU 75  76  76  LEU LEU A . n 
A 1 76  GLU 76  77  77  GLU GLU A . n 
A 1 77  GLU 77  78  78  GLU GLU A . n 
A 1 78  LEU 78  79  79  LEU LEU A . n 
A 1 79  ILE 79  80  80  ILE ILE A . n 
A 1 80  GLU 80  81  81  GLU GLU A . n 
A 1 81  GLU 81  82  82  GLU GLU A . n 
A 1 82  VAL 82  83  83  VAL VAL A . n 
A 1 83  LYS 83  84  84  LYS LYS A . n 
A 1 84  LYS 84  85  85  LYS LYS A . n 
A 1 85  GLU 85  86  86  GLU GLU A . n 
A 1 86  ILE 86  87  87  ILE ILE A . n 
A 1 87  LYS 87  88  88  LYS LYS A . n 
A 1 88  GLU 88  89  89  GLU GLU A . n 
A 1 89  LEU 89  90  90  LEU LEU A . n 
A 1 90  PHE 90  91  91  PHE PHE A . n 
A 1 91  ASP 91  92  92  ASP ASP A . n 
A 1 92  GLU 92  93  93  GLU GLU A . n 
A 1 93  LEU 93  94  94  LEU LEU A . n 
A 1 94  LYS 94  95  95  LYS LYS A . n 
A 1 95  LYS 95  96  96  LYS LYS A . n 
A 1 96  MET 96  97  97  MET MET A . n 
A 1 97  ILE 97  98  98  ILE ILE A . n 
A 1 98  LYS 98  99  99  LYS LYS A . n 
A 1 99  GLU 99  100 100 GLU GLU A . n 
A 1 100 GLY 100 101 101 GLY GLY A . n 
A 1 101 GLU 101 102 102 GLU GLU A . n 
A 1 102 SER 102 103 103 SER SER A . n 
A 1 103 LYS 103 104 104 LYS LYS A . n 
A 1 104 GLU 104 105 105 GLU GLU A . n 
A 1 105 LYS 105 106 106 LYS LYS A . n 
A 1 106 ILE 106 107 107 ILE ILE A . n 
A 1 107 ILE 107 108 108 ILE ILE A . n 
A 1 108 ILE 108 109 109 ILE ILE A . n 
A 1 109 TYR 109 110 110 TYR TYR A . n 
A 1 110 ASN 110 111 111 ASN ASN A . n 
A 1 111 ILE 111 112 112 ILE ILE A . n 
A 1 112 LEU 112 113 113 LEU LEU A . n 
A 1 113 LYS 113 114 114 LYS LYS A . n 
A 1 114 ASN 114 115 115 ASN ASN A . n 
A 1 115 PHE 115 116 116 PHE PHE A . n 
A 1 116 GLU 116 117 117 GLU GLU A . n 
A 1 117 LEU 117 118 118 LEU LEU A . n 
A 1 118 GLU 118 119 119 GLU GLU A . n 
A 1 119 ILE 119 120 120 ILE ILE A . n 
A 1 120 LEU 120 121 121 LEU LEU A . n 
A 1 121 LEU 121 122 122 LEU LEU A . n 
A 1 122 ALA 122 123 123 ALA ALA A . n 
A 1 123 MET 123 124 124 MET MET A . n 
A 1 124 ILE 124 125 125 ILE ILE A . n 
A 1 125 GLU 125 126 126 GLU GLU A . n 
A 1 126 LYS 126 127 127 LYS LYS A . n 
A 1 127 GLY 127 128 128 GLY GLY A . n 
A 1 128 GLU 128 129 129 GLU GLU A . n 
A 1 129 LYS 129 130 130 LYS LYS A . n 
A 1 130 GLU 130 131 131 GLU GLU A . n 
A 1 131 GLU 131 132 132 GLU GLU A . n 
A 1 132 GLU 132 133 133 GLU GLU A . n 
A 1 133 ILE 133 134 134 ILE ILE A . n 
A 1 134 GLU 134 135 135 GLU GLU A . n 
A 1 135 LYS 135 136 136 LYS LYS A . n 
A 1 136 TYR 136 137 137 TYR TYR A . n 
A 1 137 ARG 137 138 138 ARG ARG A . n 
A 1 138 LYS 138 139 139 LYS LYS A . n 
A 1 139 LYS 139 140 140 LYS LYS A . n 
A 1 140 TRP 140 141 141 TRP TRP A . n 
A 1 141 GLU 141 142 142 GLU GLU A . n 
A 1 142 GLU 142 143 143 GLU GLU A . n 
A 1 143 LYS 143 144 144 LYS LYS A . n 
A 1 144 LEU 144 145 145 LEU LEU A . n 
A 1 145 LYS 145 146 146 LYS LYS A . n 
A 1 146 LYS 146 147 147 LYS LYS A . n 
A 1 147 TYR 147 148 148 TYR TYR A . n 
A 1 148 LEU 148 149 149 LEU LEU A . n 
A 1 149 GLU 149 150 150 GLU GLU A . n 
A 1 150 GLU 150 151 151 GLU GLU A . n 
A 1 151 VAL 151 152 152 VAL VAL A . n 
A 1 152 LYS 152 153 153 LYS LYS A . n 
A 1 153 THR 153 154 154 THR THR A . n 
A 1 154 LYS 154 155 155 LYS LYS A . n 
A 1 155 GLU 155 156 156 GLU GLU A . n 
A 1 156 GLU 156 157 157 GLU GLU A . n 
A 1 157 ALA 157 158 158 ALA ALA A . n 
A 1 158 LEU 158 159 159 LEU LEU A . n 
A 1 159 LYS 159 160 160 LYS LYS A . n 
A 1 160 ILE 160 161 161 ILE ILE A . n 
A 1 161 LEU 161 162 162 LEU LEU A . n 
A 1 162 GLU 162 163 163 GLU GLU A . n 
A 1 163 GLU 163 164 164 GLU GLU A . n 
A 1 164 ILE 164 165 165 ILE ILE A . n 
A 1 165 LEU 165 166 166 LEU LEU A . n 
A 1 166 LYS 166 167 167 LYS LYS A . n 
A 1 167 GLU 167 168 168 GLU GLU A . n 
A 1 168 ARG 168 169 169 ARG ARG A . n 
A 1 169 LYS 169 170 170 LYS LYS A . n 
A 1 170 GLU 170 171 171 GLU GLU A . n 
A 1 171 GLU 171 172 172 GLU GLU A . n 
A 1 172 LEU 172 173 173 LEU LEU A . n 
A 1 173 GLU 173 174 174 GLU GLU A . n 
A 1 174 LYS 174 175 175 LYS LYS A . n 
A 1 175 LEU 175 176 176 LEU LEU A . n 
A 1 176 GLY 176 177 177 GLY GLY A . n 
A 1 177 ILE 177 178 178 ILE ILE A . n 
A 1 178 SER 178 179 179 SER SER A . n 
A 1 179 LYS 179 180 180 LYS LYS A . n 
A 1 180 GLU 180 181 181 GLU GLU A . n 
A 1 181 LEU 181 182 182 LEU LEU A . n 
A 1 182 VAL 182 183 183 VAL VAL A . n 
A 1 183 GLU 183 184 184 GLU GLU A . n 
A 1 184 LYS 184 185 185 LYS LYS A . n 
A 1 185 HIS 185 186 186 HIS HIS A . n 
A 1 186 LEU 186 187 187 LEU LEU A . n 
A 1 187 GLU 187 188 188 GLU GLU A . n 
A 1 188 ARG 188 189 189 ARG ARG A . n 
A 1 189 ILE 189 190 190 ILE ILE A . n 
A 1 190 LYS 190 191 191 LYS LYS A . n 
A 1 191 LYS 191 192 192 LYS LYS A . n 
A 1 192 ALA 192 193 193 ALA ALA A . n 
A 1 193 ALA 193 194 194 ALA ALA A . n 
A 1 194 GLU 194 195 195 GLU GLU A . n 
A 1 195 LEU 195 196 196 LEU LEU A . n 
A 1 196 VAL 196 197 197 VAL VAL A . n 
A 1 197 LEU 197 198 198 LEU LEU A . n 
A 1 198 SER 198 199 199 SER SER A . n 
A 1 199 MET 199 200 200 MET MET A . n 
A 1 200 GLY 200 201 201 GLY GLY A . n 
A 1 201 SER 201 202 202 SER SER A . n 
A 1 202 LEU 202 203 203 LEU LEU A . n 
A 1 203 GLU 203 204 204 GLU GLU A . n 
A 1 204 SER 204 205 205 SER SER A . n 
A 1 205 SER 205 206 206 SER SER A . n 
A 1 206 GLY 206 207 207 GLY GLY A . n 
A 1 207 LEU 207 208 208 LEU LEU A . n 
A 1 208 GLU 208 209 209 GLU GLU A . n 
A 1 209 VAL 209 210 210 VAL VAL A . n 
A 1 210 LEU 210 211 211 LEU LEU A . n 
A 1 211 PHE 211 212 212 PHE PHE A . n 
A 1 212 GLN 212 213 213 GLN GLN A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ZN  1   301 1   ZN  ZN  A . 
C 2 ZN  1   302 2   ZN  ZN  A . 
D 2 ZN  1   303 3   ZN  ZN  A . 
E 2 ZN  1   304 4   ZN  ZN  A . 
F 2 ZN  1   305 5   ZN  ZN  A . 
G 2 ZN  1   306 6   ZN  ZN  A . 
H 2 ZN  1   307 7   ZN  ZN  A . 
I 3 HOH 1   401 126 HOH HOH A . 
I 3 HOH 2   402 160 HOH HOH A . 
I 3 HOH 3   403 48  HOH HOH A . 
I 3 HOH 4   404 147 HOH HOH A . 
I 3 HOH 5   405 163 HOH HOH A . 
I 3 HOH 6   406 132 HOH HOH A . 
I 3 HOH 7   407 135 HOH HOH A . 
I 3 HOH 8   408 168 HOH HOH A . 
I 3 HOH 9   409 156 HOH HOH A . 
I 3 HOH 10  410 161 HOH HOH A . 
I 3 HOH 11  411 130 HOH HOH A . 
I 3 HOH 12  412 133 HOH HOH A . 
I 3 HOH 13  413 97  HOH HOH A . 
I 3 HOH 14  414 92  HOH HOH A . 
I 3 HOH 15  415 79  HOH HOH A . 
I 3 HOH 16  416 84  HOH HOH A . 
I 3 HOH 17  417 57  HOH HOH A . 
I 3 HOH 18  418 5   HOH HOH A . 
I 3 HOH 19  419 158 HOH HOH A . 
I 3 HOH 20  420 127 HOH HOH A . 
I 3 HOH 21  421 164 HOH HOH A . 
I 3 HOH 22  422 165 HOH HOH A . 
I 3 HOH 23  423 66  HOH HOH A . 
I 3 HOH 24  424 155 HOH HOH A . 
I 3 HOH 25  425 65  HOH HOH A . 
I 3 HOH 26  426 166 HOH HOH A . 
I 3 HOH 27  427 171 HOH HOH A . 
I 3 HOH 28  428 124 HOH HOH A . 
I 3 HOH 29  429 89  HOH HOH A . 
I 3 HOH 30  430 60  HOH HOH A . 
I 3 HOH 31  431 136 HOH HOH A . 
I 3 HOH 32  432 169 HOH HOH A . 
I 3 HOH 33  433 118 HOH HOH A . 
I 3 HOH 34  434 128 HOH HOH A . 
I 3 HOH 35  435 104 HOH HOH A . 
I 3 HOH 36  436 10  HOH HOH A . 
I 3 HOH 37  437 153 HOH HOH A . 
I 3 HOH 38  438 152 HOH HOH A . 
I 3 HOH 39  439 25  HOH HOH A . 
I 3 HOH 40  440 113 HOH HOH A . 
I 3 HOH 41  441 111 HOH HOH A . 
I 3 HOH 42  442 142 HOH HOH A . 
I 3 HOH 43  443 77  HOH HOH A . 
I 3 HOH 44  444 14  HOH HOH A . 
I 3 HOH 45  445 67  HOH HOH A . 
I 3 HOH 46  446 129 HOH HOH A . 
I 3 HOH 47  447 23  HOH HOH A . 
I 3 HOH 48  448 106 HOH HOH A . 
I 3 HOH 49  449 64  HOH HOH A . 
I 3 HOH 50  450 120 HOH HOH A . 
I 3 HOH 51  451 35  HOH HOH A . 
I 3 HOH 52  452 81  HOH HOH A . 
I 3 HOH 53  453 85  HOH HOH A . 
I 3 HOH 54  454 74  HOH HOH A . 
I 3 HOH 55  455 91  HOH HOH A . 
I 3 HOH 56  456 31  HOH HOH A . 
I 3 HOH 57  457 72  HOH HOH A . 
I 3 HOH 58  458 110 HOH HOH A . 
I 3 HOH 59  459 28  HOH HOH A . 
I 3 HOH 60  460 53  HOH HOH A . 
I 3 HOH 61  461 141 HOH HOH A . 
I 3 HOH 62  462 49  HOH HOH A . 
I 3 HOH 63  463 149 HOH HOH A . 
I 3 HOH 64  464 52  HOH HOH A . 
I 3 HOH 65  465 143 HOH HOH A . 
I 3 HOH 66  466 26  HOH HOH A . 
I 3 HOH 67  467 76  HOH HOH A . 
I 3 HOH 68  468 150 HOH HOH A . 
I 3 HOH 69  469 37  HOH HOH A . 
I 3 HOH 70  470 78  HOH HOH A . 
I 3 HOH 71  471 13  HOH HOH A . 
I 3 HOH 72  472 122 HOH HOH A . 
I 3 HOH 73  473 27  HOH HOH A . 
I 3 HOH 74  474 24  HOH HOH A . 
I 3 HOH 75  475 44  HOH HOH A . 
I 3 HOH 76  476 123 HOH HOH A . 
I 3 HOH 77  477 170 HOH HOH A . 
I 3 HOH 78  478 115 HOH HOH A . 
I 3 HOH 79  479 59  HOH HOH A . 
I 3 HOH 80  480 18  HOH HOH A . 
I 3 HOH 81  481 140 HOH HOH A . 
I 3 HOH 82  482 70  HOH HOH A . 
I 3 HOH 83  483 102 HOH HOH A . 
I 3 HOH 84  484 80  HOH HOH A . 
I 3 HOH 85  485 119 HOH HOH A . 
I 3 HOH 86  486 4   HOH HOH A . 
I 3 HOH 87  487 6   HOH HOH A . 
I 3 HOH 88  488 62  HOH HOH A . 
I 3 HOH 89  489 148 HOH HOH A . 
I 3 HOH 90  490 103 HOH HOH A . 
I 3 HOH 91  491 51  HOH HOH A . 
I 3 HOH 92  492 88  HOH HOH A . 
I 3 HOH 93  493 46  HOH HOH A . 
I 3 HOH 94  494 54  HOH HOH A . 
I 3 HOH 95  495 45  HOH HOH A . 
I 3 HOH 96  496 112 HOH HOH A . 
I 3 HOH 97  497 99  HOH HOH A . 
I 3 HOH 98  498 32  HOH HOH A . 
I 3 HOH 99  499 71  HOH HOH A . 
I 3 HOH 100 500 83  HOH HOH A . 
I 3 HOH 101 501 22  HOH HOH A . 
I 3 HOH 102 502 43  HOH HOH A . 
I 3 HOH 103 503 82  HOH HOH A . 
I 3 HOH 104 504 151 HOH HOH A . 
I 3 HOH 105 505 144 HOH HOH A . 
I 3 HOH 106 506 7   HOH HOH A . 
I 3 HOH 107 507 105 HOH HOH A . 
I 3 HOH 108 508 167 HOH HOH A . 
I 3 HOH 109 509 33  HOH HOH A . 
I 3 HOH 110 510 68  HOH HOH A . 
I 3 HOH 111 511 8   HOH HOH A . 
I 3 HOH 112 512 101 HOH HOH A . 
I 3 HOH 113 513 121 HOH HOH A . 
I 3 HOH 114 514 96  HOH HOH A . 
I 3 HOH 115 515 40  HOH HOH A . 
I 3 HOH 116 516 125 HOH HOH A . 
I 3 HOH 117 517 134 HOH HOH A . 
I 3 HOH 118 518 114 HOH HOH A . 
I 3 HOH 119 519 90  HOH HOH A . 
I 3 HOH 120 520 87  HOH HOH A . 
I 3 HOH 121 521 108 HOH HOH A . 
I 3 HOH 122 522 109 HOH HOH A . 
I 3 HOH 123 523 41  HOH HOH A . 
I 3 HOH 124 524 131 HOH HOH A . 
I 3 HOH 125 525 107 HOH HOH A . 
I 3 HOH 126 526 39  HOH HOH A . 
I 3 HOH 127 527 100 HOH HOH A . 
I 3 HOH 128 528 95  HOH HOH A . 
I 3 HOH 129 529 69  HOH HOH A . 
I 3 HOH 130 530 162 HOH HOH A . 
I 3 HOH 131 531 50  HOH HOH A . 
I 3 HOH 132 532 145 HOH HOH A . 
I 3 HOH 133 533 38  HOH HOH A . 
I 3 HOH 134 534 73  HOH HOH A . 
I 3 HOH 135 535 42  HOH HOH A . 
I 3 HOH 136 536 17  HOH HOH A . 
I 3 HOH 137 537 20  HOH HOH A . 
I 3 HOH 138 538 61  HOH HOH A . 
I 3 HOH 139 539 34  HOH HOH A . 
I 3 HOH 140 540 9   HOH HOH A . 
I 3 HOH 141 541 159 HOH HOH A . 
I 3 HOH 142 542 75  HOH HOH A . 
I 3 HOH 143 543 139 HOH HOH A . 
I 3 HOH 144 544 137 HOH HOH A . 
I 3 HOH 145 545 94  HOH HOH A . 
I 3 HOH 146 546 29  HOH HOH A . 
I 3 HOH 147 547 86  HOH HOH A . 
I 3 HOH 148 548 11  HOH HOH A . 
I 3 HOH 149 549 30  HOH HOH A . 
I 3 HOH 150 550 138 HOH HOH A . 
I 3 HOH 151 551 15  HOH HOH A . 
I 3 HOH 152 552 47  HOH HOH A . 
I 3 HOH 153 553 98  HOH HOH A . 
I 3 HOH 154 554 19  HOH HOH A . 
I 3 HOH 155 555 12  HOH HOH A . 
I 3 HOH 156 556 36  HOH HOH A . 
I 3 HOH 157 557 93  HOH HOH A . 
I 3 HOH 158 558 157 HOH HOH A . 
I 3 HOH 159 559 116 HOH HOH A . 
I 3 HOH 160 560 154 HOH HOH A . 
I 3 HOH 161 561 146 HOH HOH A . 
I 3 HOH 162 562 117 HOH HOH A . 
I 3 HOH 163 563 21  HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A LYS 25  ? CG  ? A LYS 24  CG  
2  1 Y 1 A LYS 25  ? CD  ? A LYS 24  CD  
3  1 Y 1 A LYS 25  ? CE  ? A LYS 24  CE  
4  1 Y 1 A LYS 25  ? NZ  ? A LYS 24  NZ  
5  1 Y 1 A GLU 65  ? CG  ? A GLU 64  CG  
6  1 Y 1 A GLU 65  ? CD  ? A GLU 64  CD  
7  1 Y 1 A GLU 65  ? OE1 ? A GLU 64  OE1 
8  1 Y 1 A GLU 65  ? OE2 ? A GLU 64  OE2 
9  1 Y 1 A LYS 99  ? CD  ? A LYS 98  CD  
10 1 Y 1 A LYS 99  ? CE  ? A LYS 98  CE  
11 1 Y 1 A LYS 99  ? NZ  ? A LYS 98  NZ  
12 1 Y 1 A GLU 195 ? CG  ? A GLU 194 CG  
13 1 Y 1 A GLU 195 ? CD  ? A GLU 194 CD  
14 1 Y 1 A GLU 195 ? OE1 ? A GLU 194 OE1 
15 1 Y 1 A GLU 195 ? OE2 ? A GLU 194 OE2 
16 1 Y 1 A SER 202 ? OG  ? A SER 201 OG  
17 1 Y 1 A LEU 203 ? CG  ? A LEU 202 CG  
18 1 Y 1 A LEU 203 ? CD1 ? A LEU 202 CD1 
19 1 Y 1 A LEU 203 ? CD2 ? A LEU 202 CD2 
20 1 Y 1 A GLU 204 ? CG  ? A GLU 203 CG  
21 1 Y 1 A GLU 204 ? CD  ? A GLU 203 CD  
22 1 Y 1 A GLU 204 ? OE1 ? A GLU 203 OE1 
23 1 Y 1 A GLU 204 ? OE2 ? A GLU 203 OE2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? '(1.20.1_4487: ???)' 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .                    2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .                    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .                    4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   108.52 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9LNI 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     35.281 
_cell.length_a_esd                 ? 
_cell.length_b                     67.380 
_cell.length_b_esd                 ? 
_cell.length_c                     43.742 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        2 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9LNI 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9LNI 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             1.98 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          37.75 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'Zinc acetate dihydrate, MES, PEG 8000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 S 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-06-20 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9792 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL02U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9792 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL02U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9LNI 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.61 
_reflns.d_resolution_low                               41.48 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     24327 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           97.3 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                4.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          8.3 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.997 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.61 
_reflns_shell.d_res_low                                     1.70 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3468 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.867 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9LNI 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.61 
_refine.ls_d_res_low                             28.43 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     24303 
_refine.ls_number_reflns_R_free                  1165 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    97.01 
_refine.ls_percent_reflns_R_free                 4.79 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2102 
_refine.ls_R_factor_R_free                       0.2429 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2085 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.38 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 26.96 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.17 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        1724 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         7 
_refine_hist.number_atoms_solvent             163 
_refine_hist.number_atoms_total               1894 
_refine_hist.d_res_high                       1.61 
_refine_hist.d_res_low                        28.43 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.008 ? ?   ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.102 ? ?   ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 4.427 ? 221 ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.058 ? 279 ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.007 ? 285 ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.61 1.69  . . 136 2830 95.00 . . . . 0.2562 . . . . . . . . . . . 0.2667 
'X-RAY DIFFRACTION' 1.69 1.77  . . 148 2846 96.00 . . . . 0.2538 . . . . . . . . . . . 0.2849 
'X-RAY DIFFRACTION' 1.77 1.89  . . 146 2856 97.00 . . . . 0.2312 . . . . . . . . . . . 0.2713 
'X-RAY DIFFRACTION' 1.89 2.03  . . 136 2916 97.00 . . . . 0.2298 . . . . . . . . . . . 0.2818 
'X-RAY DIFFRACTION' 2.03 2.24  . . 145 2915 98.00 . . . . 0.2113 . . . . . . . . . . . 0.2524 
'X-RAY DIFFRACTION' 2.24 2.56  . . 152 2914 98.00 . . . . 0.2119 . . . . . . . . . . . 0.2334 
'X-RAY DIFFRACTION' 2.56 3.22  . . 146 2939 98.00 . . . . 0.2164 . . . . . . . . . . . 0.2572 
'X-RAY DIFFRACTION' 3.22 28.43 . . 156 2922 97.00 . . . . 0.1883 . . . . . . . . . . . 0.2221 
# 
_struct.entry_id                     9LNI 
_struct.title                        'Crystal structure of the de novo designed protein ZZ1' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9LNI 
_struct_keywords.text            'De novo protein' 
_struct_keywords.pdbx_keywords   'DE NOVO PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 2 ? 
E N N 2 ? 
F N N 2 ? 
G N N 2 ? 
H N N 2 ? 
I N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    PDB 
_struct_ref.db_code                    9LNI 
_struct_ref.pdbx_db_accession          9LNI 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   ? 
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9LNI 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 212 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             9LNI 
_struct_ref_seq.db_align_beg                  2 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  213 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       2 
_struct_ref_seq.pdbx_auth_seq_align_end       213 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 150   ? 
1 MORE         -47   ? 
1 'SSA (A^2)'  11140 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 1   ? LYS A 22  ? SER A 2   LYS A 23  1 ? 22 
HELX_P HELX_P2  AA2 SER A 27  ? GLU A 50  ? SER A 28  GLU A 51  1 ? 24 
HELX_P HELX_P3  AA3 ASP A 51  ? VAL A 73  ? ASP A 52  VAL A 74  1 ? 23 
HELX_P HELX_P4  AA4 LEU A 75  ? GLU A 77  ? LEU A 76  GLU A 78  5 ? 3  
HELX_P HELX_P5  AA5 LEU A 78  ? GLU A 99  ? LEU A 79  GLU A 100 1 ? 22 
HELX_P HELX_P6  AA6 SER A 102 ? GLY A 127 ? SER A 103 GLY A 128 1 ? 26 
HELX_P HELX_P7  AA7 LYS A 129 ? VAL A 151 ? LYS A 130 VAL A 152 1 ? 23 
HELX_P HELX_P8  AA8 THR A 153 ? LEU A 175 ? THR A 154 LEU A 176 1 ? 23 
HELX_P HELX_P9  AA9 SER A 178 ? MET A 199 ? SER A 179 MET A 200 1 ? 22 
HELX_P HELX_P10 AB1 GLU A 203 ? GLN A 212 ? GLU A 204 GLN A 213 1 ? 10 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A GLU 19  OE1 ? ? ? 1_555 C ZN  . ZN ? ? A GLU 20  A ZN  302 1_555 ? ? ? ? ? ? ? 1.943 ? ? 
metalc2  metalc ? ? A GLU 34  OE1 ? ? ? 1_555 C ZN  . ZN ? ? A GLU 35  A ZN  302 1_555 ? ? ? ? ? ? ? 2.613 ? ? 
metalc3  metalc ? ? A GLU 34  OE2 ? ? ? 1_555 C ZN  . ZN ? ? A GLU 35  A ZN  302 1_555 ? ? ? ? ? ? ? 1.934 ? ? 
metalc4  metalc ? ? A GLU 50  OE1 ? ? ? 1_555 D ZN  . ZN ? ? A GLU 51  A ZN  303 1_555 ? ? ? ? ? ? ? 2.571 ? ? 
metalc5  metalc ? ? A GLU 50  OE2 ? ? ? 1_555 D ZN  . ZN ? ? A GLU 51  A ZN  303 1_555 ? ? ? ? ? ? ? 2.288 ? ? 
metalc6  metalc ? ? A ASP 51  OD1 ? ? ? 1_555 B ZN  . ZN ? ? A ASP 52  A ZN  301 1_555 ? ? ? ? ? ? ? 1.943 ? ? 
metalc7  metalc ? ? A GLU 53  OE1 ? ? ? 1_555 B ZN  . ZN ? ? A GLU 54  A ZN  301 1_555 ? ? ? ? ? ? ? 2.626 ? ? 
metalc8  metalc ? ? A GLU 53  OE2 ? ? ? 1_555 B ZN  . ZN ? ? A GLU 54  A ZN  301 1_555 ? ? ? ? ? ? ? 1.993 ? ? 
metalc9  metalc ? ? A LYS 57  NZ  ? ? ? 1_555 E ZN  . ZN ? ? A LYS 58  A ZN  304 2_556 ? ? ? ? ? ? ? 2.427 ? ? 
metalc10 metalc ? ? A GLU 60  OE2 ? ? ? 1_555 F ZN  . ZN ? ? A GLU 61  A ZN  305 1_555 ? ? ? ? ? ? ? 2.275 ? ? 
metalc11 metalc ? ? A GLU 61  OE2 ? ? ? 1_555 E ZN  . ZN ? ? A GLU 62  A ZN  304 2_556 ? ? ? ? ? ? ? 1.909 ? ? 
metalc12 metalc ? ? A GLU 85  OE1 ? ? ? 1_555 G ZN  . ZN ? ? A GLU 86  A ZN  306 1_555 ? ? ? ? ? ? ? 2.339 ? ? 
metalc13 metalc ? ? A GLU 85  OE2 ? ? ? 1_555 G ZN  . ZN ? ? A GLU 86  A ZN  306 1_555 ? ? ? ? ? ? ? 2.699 ? ? 
metalc14 metalc ? ? A GLU 88  OE1 ? ? ? 1_555 G ZN  . ZN ? ? A GLU 89  A ZN  306 1_555 ? ? ? ? ? ? ? 2.415 ? ? 
metalc15 metalc ? ? A GLU 134 OE2 ? ? ? 1_555 F ZN  . ZN ? ? A GLU 135 A ZN  305 2_646 ? ? ? ? ? ? ? 1.992 ? ? 
metalc16 metalc ? ? A GLU 156 OE1 ? ? ? 1_555 B ZN  . ZN ? ? A GLU 157 A ZN  301 2_545 ? ? ? ? ? ? ? 2.691 ? ? 
metalc17 metalc ? ? A GLU 156 OE2 ? ? ? 1_555 B ZN  . ZN ? ? A GLU 157 A ZN  301 2_545 ? ? ? ? ? ? ? 1.854 ? ? 
metalc18 metalc ? ? A GLU 170 OE1 ? ? ? 1_555 E ZN  . ZN ? ? A GLU 171 A ZN  304 1_555 ? ? ? ? ? ? ? 2.648 ? ? 
metalc19 metalc ? ? A GLU 170 OE2 ? ? ? 1_555 E ZN  . ZN ? ? A GLU 171 A ZN  304 1_555 ? ? ? ? ? ? ? 2.275 ? ? 
metalc20 metalc ? ? A GLU 180 OE2 ? ? ? 1_555 F ZN  . ZN ? ? A GLU 181 A ZN  305 2_546 ? ? ? ? ? ? ? 1.984 ? ? 
metalc21 metalc ? ? A HIS 185 NE2 ? ? ? 1_555 C ZN  . ZN ? ? A HIS 186 A ZN  302 1_555 ? ? ? ? ? ? ? 2.182 ? ? 
metalc22 metalc ? ? A GLU 208 OE1 ? ? ? 1_555 C ZN  . ZN ? ? A GLU 209 A ZN  302 1_554 ? ? ? ? ? ? ? 2.065 ? ? 
metalc23 metalc ? ? B ZN  .   ZN  ? ? ? 1_555 I HOH . O  ? ? A ZN  301 A HOH 473 1_555 ? ? ? ? ? ? ? 1.900 ? ? 
metalc24 metalc ? ? D ZN  .   ZN  ? ? ? 1_555 I HOH . O  ? ? A ZN  303 A HOH 504 1_555 ? ? ? ? ? ? ? 2.392 ? ? 
metalc25 metalc ? ? E ZN  .   ZN  ? ? ? 1_555 I HOH . O  ? ? A ZN  304 A HOH 515 2_546 ? ? ? ? ? ? ? 2.694 ? ? 
metalc26 metalc ? ? F ZN  .   ZN  ? ? ? 1_555 I HOH . O  ? ? A ZN  305 A HOH 445 2_556 ? ? ? ? ? ? ? 1.973 ? ? 
metalc27 metalc ? ? H ZN  .   ZN  ? ? ? 1_555 I HOH . O  ? ? A ZN  307 A HOH 408 1_554 ? ? ? ? ? ? ? 1.865 ? ? 
metalc28 metalc ? ? H ZN  .   ZN  ? ? ? 1_555 I HOH . O  ? ? A ZN  307 A HOH 422 1_555 ? ? ? ? ? ? ? 2.254 ? ? 
metalc29 metalc ? ? H ZN  .   ZN  ? ? ? 1_555 I HOH . O  ? ? A ZN  307 A HOH 426 1_655 ? ? ? ? ? ? ? 2.359 ? ? 
metalc30 metalc ? ? H ZN  .   ZN  ? ? ? 1_555 I HOH . O  ? ? A ZN  307 A HOH 432 1_655 ? ? ? ? ? ? ? 2.594 ? ? 
metalc31 metalc ? ? H ZN  .   ZN  ? ? ? 1_555 I HOH . O  ? ? A ZN  307 A HOH 508 1_554 ? ? ? ? ? ? ? 2.588 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OE1 ? A GLU 19  ? A GLU 20  ? 1_555 ZN ? C ZN . ? A ZN 302 ? 1_555 OE1 ? A GLU 34  ? A GLU 35  ? 1_555 88.5  ? 
2  OE1 ? A GLU 19  ? A GLU 20  ? 1_555 ZN ? C ZN . ? A ZN 302 ? 1_555 OE2 ? A GLU 34  ? A GLU 35  ? 1_555 132.2 ? 
3  OE1 ? A GLU 34  ? A GLU 35  ? 1_555 ZN ? C ZN . ? A ZN 302 ? 1_555 OE2 ? A GLU 34  ? A GLU 35  ? 1_555 55.1  ? 
4  OE1 ? A GLU 19  ? A GLU 20  ? 1_555 ZN ? C ZN . ? A ZN 302 ? 1_555 NE2 ? A HIS 185 ? A HIS 186 ? 1_555 110.2 ? 
5  OE1 ? A GLU 34  ? A GLU 35  ? 1_555 ZN ? C ZN . ? A ZN 302 ? 1_555 NE2 ? A HIS 185 ? A HIS 186 ? 1_555 84.0  ? 
6  OE2 ? A GLU 34  ? A GLU 35  ? 1_555 ZN ? C ZN . ? A ZN 302 ? 1_555 NE2 ? A HIS 185 ? A HIS 186 ? 1_555 96.9  ? 
7  OE1 ? A GLU 19  ? A GLU 20  ? 1_555 ZN ? C ZN . ? A ZN 302 ? 1_555 OE1 ? A GLU 208 ? A GLU 209 ? 1_555 49.4  ? 
8  OE1 ? A GLU 34  ? A GLU 35  ? 1_555 ZN ? C ZN . ? A ZN 302 ? 1_555 OE1 ? A GLU 208 ? A GLU 209 ? 1_555 66.5  ? 
9  OE2 ? A GLU 34  ? A GLU 35  ? 1_555 ZN ? C ZN . ? A ZN 302 ? 1_555 OE1 ? A GLU 208 ? A GLU 209 ? 1_555 120.4 ? 
10 NE2 ? A HIS 185 ? A HIS 186 ? 1_555 ZN ? C ZN . ? A ZN 302 ? 1_555 OE1 ? A GLU 208 ? A GLU 209 ? 1_555 64.5  ? 
11 OE1 ? A GLU 50  ? A GLU 51  ? 1_555 ZN ? D ZN . ? A ZN 303 ? 1_555 OE2 ? A GLU 50  ? A GLU 51  ? 1_555 53.6  ? 
12 OE1 ? A GLU 50  ? A GLU 51  ? 1_555 ZN ? D ZN . ? A ZN 303 ? 1_555 O   ? I HOH .   ? A HOH 504 ? 1_555 124.3 ? 
13 OE2 ? A GLU 50  ? A GLU 51  ? 1_555 ZN ? D ZN . ? A ZN 303 ? 1_555 O   ? I HOH .   ? A HOH 504 ? 1_555 80.2  ? 
14 OD1 ? A ASP 51  ? A ASP 52  ? 1_555 ZN ? B ZN . ? A ZN 301 ? 1_555 OE1 ? A GLU 53  ? A GLU 54  ? 1_555 88.2  ? 
15 OD1 ? A ASP 51  ? A ASP 52  ? 1_555 ZN ? B ZN . ? A ZN 301 ? 1_555 OE2 ? A GLU 53  ? A GLU 54  ? 1_555 115.0 ? 
16 OE1 ? A GLU 53  ? A GLU 54  ? 1_555 ZN ? B ZN . ? A ZN 301 ? 1_555 OE2 ? A GLU 53  ? A GLU 54  ? 1_555 54.5  ? 
17 OD1 ? A ASP 51  ? A ASP 52  ? 1_555 ZN ? B ZN . ? A ZN 301 ? 1_555 OE1 ? A GLU 156 ? A GLU 157 ? 1_555 11.1  ? 
18 OE1 ? A GLU 53  ? A GLU 54  ? 1_555 ZN ? B ZN . ? A ZN 301 ? 1_555 OE1 ? A GLU 156 ? A GLU 157 ? 1_555 97.6  ? 
19 OE2 ? A GLU 53  ? A GLU 54  ? 1_555 ZN ? B ZN . ? A ZN 301 ? 1_555 OE1 ? A GLU 156 ? A GLU 157 ? 1_555 125.6 ? 
20 OD1 ? A ASP 51  ? A ASP 52  ? 1_555 ZN ? B ZN . ? A ZN 301 ? 1_555 OE2 ? A GLU 156 ? A GLU 157 ? 1_555 11.5  ? 
21 OE1 ? A GLU 53  ? A GLU 54  ? 1_555 ZN ? B ZN . ? A ZN 301 ? 1_555 OE2 ? A GLU 156 ? A GLU 157 ? 1_555 98.5  ? 
22 OE2 ? A GLU 53  ? A GLU 54  ? 1_555 ZN ? B ZN . ? A ZN 301 ? 1_555 OE2 ? A GLU 156 ? A GLU 157 ? 1_555 125.6 ? 
23 OE1 ? A GLU 156 ? A GLU 157 ? 1_555 ZN ? B ZN . ? A ZN 301 ? 1_555 OE2 ? A GLU 156 ? A GLU 157 ? 1_555 1.1   ? 
24 OD1 ? A ASP 51  ? A ASP 52  ? 1_555 ZN ? B ZN . ? A ZN 301 ? 1_555 O   ? I HOH .   ? A HOH 473 ? 1_555 94.4  ? 
25 OE1 ? A GLU 53  ? A GLU 54  ? 1_555 ZN ? B ZN . ? A ZN 301 ? 1_555 O   ? I HOH .   ? A HOH 473 ? 1_555 161.5 ? 
26 OE2 ? A GLU 53  ? A GLU 54  ? 1_555 ZN ? B ZN . ? A ZN 301 ? 1_555 O   ? I HOH .   ? A HOH 473 ? 1_555 108.4 ? 
27 OE1 ? A GLU 156 ? A GLU 157 ? 1_555 ZN ? B ZN . ? A ZN 301 ? 1_555 O   ? I HOH .   ? A HOH 473 ? 1_555 87.3  ? 
28 OE2 ? A GLU 156 ? A GLU 157 ? 1_555 ZN ? B ZN . ? A ZN 301 ? 1_555 O   ? I HOH .   ? A HOH 473 ? 1_555 86.3  ? 
29 NZ  ? A LYS 57  ? A LYS 58  ? 1_555 ZN ? E ZN . ? A ZN 304 ? 2_556 OE2 ? A GLU 61  ? A GLU 62  ? 1_555 93.2  ? 
30 NZ  ? A LYS 57  ? A LYS 58  ? 1_555 ZN ? E ZN . ? A ZN 304 ? 2_556 OE1 ? A GLU 170 ? A GLU 171 ? 1_555 96.8  ? 
31 OE2 ? A GLU 61  ? A GLU 62  ? 1_555 ZN ? E ZN . ? A ZN 304 ? 2_556 OE1 ? A GLU 170 ? A GLU 171 ? 1_555 76.0  ? 
32 NZ  ? A LYS 57  ? A LYS 58  ? 1_555 ZN ? E ZN . ? A ZN 304 ? 2_556 OE2 ? A GLU 170 ? A GLU 171 ? 1_555 96.9  ? 
33 OE2 ? A GLU 61  ? A GLU 62  ? 1_555 ZN ? E ZN . ? A ZN 304 ? 2_556 OE2 ? A GLU 170 ? A GLU 171 ? 1_555 79.5  ? 
34 OE1 ? A GLU 170 ? A GLU 171 ? 1_555 ZN ? E ZN . ? A ZN 304 ? 2_556 OE2 ? A GLU 170 ? A GLU 171 ? 1_555 3.5   ? 
35 NZ  ? A LYS 57  ? A LYS 58  ? 1_555 ZN ? E ZN . ? A ZN 304 ? 2_556 O   ? I HOH .   ? A HOH 515 ? 2_546 97.9  ? 
36 OE2 ? A GLU 61  ? A GLU 62  ? 1_555 ZN ? E ZN . ? A ZN 304 ? 2_556 O   ? I HOH .   ? A HOH 515 ? 2_546 77.4  ? 
37 OE1 ? A GLU 170 ? A GLU 171 ? 1_555 ZN ? E ZN . ? A ZN 304 ? 2_556 O   ? I HOH .   ? A HOH 515 ? 2_546 1.9   ? 
38 OE2 ? A GLU 170 ? A GLU 171 ? 1_555 ZN ? E ZN . ? A ZN 304 ? 2_556 O   ? I HOH .   ? A HOH 515 ? 2_546 2.3   ? 
39 OE2 ? A GLU 60  ? A GLU 61  ? 1_555 ZN ? F ZN . ? A ZN 305 ? 1_555 OE2 ? A GLU 134 ? A GLU 135 ? 1_555 29.6  ? 
40 OE2 ? A GLU 60  ? A GLU 61  ? 1_555 ZN ? F ZN . ? A ZN 305 ? 1_555 OE2 ? A GLU 180 ? A GLU 181 ? 1_555 62.4  ? 
41 OE2 ? A GLU 134 ? A GLU 135 ? 1_555 ZN ? F ZN . ? A ZN 305 ? 1_555 OE2 ? A GLU 180 ? A GLU 181 ? 1_555 49.5  ? 
42 OE2 ? A GLU 60  ? A GLU 61  ? 1_555 ZN ? F ZN . ? A ZN 305 ? 1_555 O   ? I HOH .   ? A HOH 445 ? 2_556 118.6 ? 
43 OE2 ? A GLU 134 ? A GLU 135 ? 1_555 ZN ? F ZN . ? A ZN 305 ? 1_555 O   ? I HOH .   ? A HOH 445 ? 2_556 89.9  ? 
44 OE2 ? A GLU 180 ? A GLU 181 ? 1_555 ZN ? F ZN . ? A ZN 305 ? 1_555 O   ? I HOH .   ? A HOH 445 ? 2_556 68.0  ? 
45 OE1 ? A GLU 85  ? A GLU 86  ? 1_555 ZN ? G ZN . ? A ZN 306 ? 1_555 OE2 ? A GLU 85  ? A GLU 86  ? 1_555 51.0  ? 
46 OE1 ? A GLU 85  ? A GLU 86  ? 1_555 ZN ? G ZN . ? A ZN 306 ? 1_555 OE1 ? A GLU 88  ? A GLU 89  ? 1_555 100.0 ? 
47 OE2 ? A GLU 85  ? A GLU 86  ? 1_555 ZN ? G ZN . ? A ZN 306 ? 1_555 OE1 ? A GLU 88  ? A GLU 89  ? 1_555 116.7 ? 
48 O   ? I HOH .   ? A HOH 408 ? 1_554 ZN ? H ZN . ? A ZN 307 ? 1_555 O   ? I HOH .   ? A HOH 422 ? 1_555 132.9 ? 
49 O   ? I HOH .   ? A HOH 408 ? 1_554 ZN ? H ZN . ? A ZN 307 ? 1_555 O   ? I HOH .   ? A HOH 426 ? 1_655 126.0 ? 
50 O   ? I HOH .   ? A HOH 422 ? 1_555 ZN ? H ZN . ? A ZN 307 ? 1_555 O   ? I HOH .   ? A HOH 426 ? 1_655 59.4  ? 
51 O   ? I HOH .   ? A HOH 408 ? 1_554 ZN ? H ZN . ? A ZN 307 ? 1_555 O   ? I HOH .   ? A HOH 432 ? 1_655 146.8 ? 
52 O   ? I HOH .   ? A HOH 422 ? 1_555 ZN ? H ZN . ? A ZN 307 ? 1_555 O   ? I HOH .   ? A HOH 432 ? 1_655 61.1  ? 
53 O   ? I HOH .   ? A HOH 426 ? 1_655 ZN ? H ZN . ? A ZN 307 ? 1_555 O   ? I HOH .   ? A HOH 432 ? 1_655 87.2  ? 
54 O   ? I HOH .   ? A HOH 408 ? 1_554 ZN ? H ZN . ? A ZN 307 ? 1_555 O   ? I HOH .   ? A HOH 508 ? 1_554 53.7  ? 
55 O   ? I HOH .   ? A HOH 422 ? 1_555 ZN ? H ZN . ? A ZN 307 ? 1_555 O   ? I HOH .   ? A HOH 508 ? 1_554 105.1 ? 
56 O   ? I HOH .   ? A HOH 426 ? 1_655 ZN ? H ZN . ? A ZN 307 ? 1_555 O   ? I HOH .   ? A HOH 508 ? 1_554 72.4  ? 
57 O   ? I HOH .   ? A HOH 432 ? 1_655 ZN ? H ZN . ? A ZN 307 ? 1_555 O   ? I HOH .   ? A HOH 508 ? 1_554 159.5 ? 
# 
_pdbx_entry_details.entry_id                   9LNI 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 OE1 A GLU 119 ? ? O A HOH 401 ? ? 1.95 
2  1 O   A HOH 401 ? ? O A HOH 441 ? ? 1.95 
3  1 O   A HOH 403 ? ? O A HOH 462 ? ? 1.95 
4  1 NH2 A ARG 189 ? ? O A HOH 402 ? ? 1.97 
5  1 OE2 A GLU 68  ? ? O A HOH 403 ? ? 1.99 
6  1 OE1 A GLU 16  ? ? O A HOH 404 ? ? 2.01 
7  1 O   A HOH 402 ? ? O A HOH 449 ? ? 2.03 
8  1 NZ  A LYS 147 ? ? O A HOH 405 ? ? 2.04 
9  1 O   A HOH 435 ? ? O A HOH 471 ? ? 2.06 
10 1 OE1 A GLU 129 ? ? O A HOH 406 ? ? 2.09 
11 1 OE1 A GLU 168 ? ? O A HOH 407 ? ? 2.11 
12 1 O   A HOH 408 ? ? O A HOH 508 ? ? 2.11 
13 1 OE2 A GLU 126 ? ? O A HOH 408 ? ? 2.13 
14 1 OE2 A GLU 15  ? ? O A HOH 409 ? ? 2.13 
15 1 OE2 A GLU 171 ? ? O A HOH 410 ? ? 2.13 
16 1 O   A HOH 502 ? ? O A HOH 523 ? ? 2.13 
17 1 NZ  A LYS 175 ? ? O A HOH 411 ? ? 2.14 
18 1 NZ  A LYS 136 ? ? O A HOH 412 ? ? 2.14 
19 1 OE1 A GLU 15  ? ? O A HOH 413 ? ? 2.15 
20 1 OE2 A GLU 188 ? ? O A HOH 414 ? ? 2.15 
21 1 OE2 A GLU 117 ? ? O A HOH 415 ? ? 2.16 
22 1 OE1 A GLU 135 ? ? O A HOH 416 ? ? 2.17 
# 
loop_
_pdbx_validate_symm_contact.id 
_pdbx_validate_symm_contact.PDB_model_num 
_pdbx_validate_symm_contact.auth_atom_id_1 
_pdbx_validate_symm_contact.auth_asym_id_1 
_pdbx_validate_symm_contact.auth_comp_id_1 
_pdbx_validate_symm_contact.auth_seq_id_1 
_pdbx_validate_symm_contact.PDB_ins_code_1 
_pdbx_validate_symm_contact.label_alt_id_1 
_pdbx_validate_symm_contact.site_symmetry_1 
_pdbx_validate_symm_contact.auth_atom_id_2 
_pdbx_validate_symm_contact.auth_asym_id_2 
_pdbx_validate_symm_contact.auth_comp_id_2 
_pdbx_validate_symm_contact.auth_seq_id_2 
_pdbx_validate_symm_contact.PDB_ins_code_2 
_pdbx_validate_symm_contact.label_alt_id_2 
_pdbx_validate_symm_contact.site_symmetry_2 
_pdbx_validate_symm_contact.dist 
1 1 O A HOH 403 ? ? 1_555 O A HOH 405 ? ? 2_656 1.92 
2 1 O A HOH 413 ? ? 1_555 O A HOH 511 ? ? 2_556 2.15 
3 1 O A HOH 408 ? ? 1_555 O A HOH 421 ? ? 1_556 2.19 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             CA 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             LEU 
_pdbx_validate_rmsd_angle.auth_seq_id_1              37 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CB 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             LEU 
_pdbx_validate_rmsd_angle.auth_seq_id_2              37 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             CG 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             LEU 
_pdbx_validate_rmsd_angle.auth_seq_id_3              37 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                101.23 
_pdbx_validate_rmsd_angle.angle_target_value         115.30 
_pdbx_validate_rmsd_angle.angle_deviation            -14.07 
_pdbx_validate_rmsd_angle.angle_standard_deviation   2.30 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       563 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   6.45 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
GLN N    N  N N 74  
GLN CA   C  N S 75  
GLN C    C  N N 76  
GLN O    O  N N 77  
GLN CB   C  N N 78  
GLN CG   C  N N 79  
GLN CD   C  N N 80  
GLN OE1  O  N N 81  
GLN NE2  N  N N 82  
GLN OXT  O  N N 83  
GLN H    H  N N 84  
GLN H2   H  N N 85  
GLN HA   H  N N 86  
GLN HB2  H  N N 87  
GLN HB3  H  N N 88  
GLN HG2  H  N N 89  
GLN HG3  H  N N 90  
GLN HE21 H  N N 91  
GLN HE22 H  N N 92  
GLN HXT  H  N N 93  
GLU N    N  N N 94  
GLU CA   C  N S 95  
GLU C    C  N N 96  
GLU O    O  N N 97  
GLU CB   C  N N 98  
GLU CG   C  N N 99  
GLU CD   C  N N 100 
GLU OE1  O  N N 101 
GLU OE2  O  N N 102 
GLU OXT  O  N N 103 
GLU H    H  N N 104 
GLU H2   H  N N 105 
GLU HA   H  N N 106 
GLU HB2  H  N N 107 
GLU HB3  H  N N 108 
GLU HG2  H  N N 109 
GLU HG3  H  N N 110 
GLU HE2  H  N N 111 
GLU HXT  H  N N 112 
GLY N    N  N N 113 
GLY CA   C  N N 114 
GLY C    C  N N 115 
GLY O    O  N N 116 
GLY OXT  O  N N 117 
GLY H    H  N N 118 
GLY H2   H  N N 119 
GLY HA2  H  N N 120 
GLY HA3  H  N N 121 
GLY HXT  H  N N 122 
HIS N    N  N N 123 
HIS CA   C  N S 124 
HIS C    C  N N 125 
HIS O    O  N N 126 
HIS CB   C  N N 127 
HIS CG   C  Y N 128 
HIS ND1  N  Y N 129 
HIS CD2  C  Y N 130 
HIS CE1  C  Y N 131 
HIS NE2  N  Y N 132 
HIS OXT  O  N N 133 
HIS H    H  N N 134 
HIS H2   H  N N 135 
HIS HA   H  N N 136 
HIS HB2  H  N N 137 
HIS HB3  H  N N 138 
HIS HD1  H  N N 139 
HIS HD2  H  N N 140 
HIS HE1  H  N N 141 
HIS HE2  H  N N 142 
HIS HXT  H  N N 143 
HOH O    O  N N 144 
HOH H1   H  N N 145 
HOH H2   H  N N 146 
ILE N    N  N N 147 
ILE CA   C  N S 148 
ILE C    C  N N 149 
ILE O    O  N N 150 
ILE CB   C  N S 151 
ILE CG1  C  N N 152 
ILE CG2  C  N N 153 
ILE CD1  C  N N 154 
ILE OXT  O  N N 155 
ILE H    H  N N 156 
ILE H2   H  N N 157 
ILE HA   H  N N 158 
ILE HB   H  N N 159 
ILE HG12 H  N N 160 
ILE HG13 H  N N 161 
ILE HG21 H  N N 162 
ILE HG22 H  N N 163 
ILE HG23 H  N N 164 
ILE HD11 H  N N 165 
ILE HD12 H  N N 166 
ILE HD13 H  N N 167 
ILE HXT  H  N N 168 
LEU N    N  N N 169 
LEU CA   C  N S 170 
LEU C    C  N N 171 
LEU O    O  N N 172 
LEU CB   C  N N 173 
LEU CG   C  N N 174 
LEU CD1  C  N N 175 
LEU CD2  C  N N 176 
LEU OXT  O  N N 177 
LEU H    H  N N 178 
LEU H2   H  N N 179 
LEU HA   H  N N 180 
LEU HB2  H  N N 181 
LEU HB3  H  N N 182 
LEU HG   H  N N 183 
LEU HD11 H  N N 184 
LEU HD12 H  N N 185 
LEU HD13 H  N N 186 
LEU HD21 H  N N 187 
LEU HD22 H  N N 188 
LEU HD23 H  N N 189 
LEU HXT  H  N N 190 
LYS N    N  N N 191 
LYS CA   C  N S 192 
LYS C    C  N N 193 
LYS O    O  N N 194 
LYS CB   C  N N 195 
LYS CG   C  N N 196 
LYS CD   C  N N 197 
LYS CE   C  N N 198 
LYS NZ   N  N N 199 
LYS OXT  O  N N 200 
LYS H    H  N N 201 
LYS H2   H  N N 202 
LYS HA   H  N N 203 
LYS HB2  H  N N 204 
LYS HB3  H  N N 205 
LYS HG2  H  N N 206 
LYS HG3  H  N N 207 
LYS HD2  H  N N 208 
LYS HD3  H  N N 209 
LYS HE2  H  N N 210 
LYS HE3  H  N N 211 
LYS HZ1  H  N N 212 
LYS HZ2  H  N N 213 
LYS HZ3  H  N N 214 
LYS HXT  H  N N 215 
MET N    N  N N 216 
MET CA   C  N S 217 
MET C    C  N N 218 
MET O    O  N N 219 
MET CB   C  N N 220 
MET CG   C  N N 221 
MET SD   S  N N 222 
MET CE   C  N N 223 
MET OXT  O  N N 224 
MET H    H  N N 225 
MET H2   H  N N 226 
MET HA   H  N N 227 
MET HB2  H  N N 228 
MET HB3  H  N N 229 
MET HG2  H  N N 230 
MET HG3  H  N N 231 
MET HE1  H  N N 232 
MET HE2  H  N N 233 
MET HE3  H  N N 234 
MET HXT  H  N N 235 
PHE N    N  N N 236 
PHE CA   C  N S 237 
PHE C    C  N N 238 
PHE O    O  N N 239 
PHE CB   C  N N 240 
PHE CG   C  Y N 241 
PHE CD1  C  Y N 242 
PHE CD2  C  Y N 243 
PHE CE1  C  Y N 244 
PHE CE2  C  Y N 245 
PHE CZ   C  Y N 246 
PHE OXT  O  N N 247 
PHE H    H  N N 248 
PHE H2   H  N N 249 
PHE HA   H  N N 250 
PHE HB2  H  N N 251 
PHE HB3  H  N N 252 
PHE HD1  H  N N 253 
PHE HD2  H  N N 254 
PHE HE1  H  N N 255 
PHE HE2  H  N N 256 
PHE HZ   H  N N 257 
PHE HXT  H  N N 258 
PRO N    N  N N 259 
PRO CA   C  N S 260 
PRO C    C  N N 261 
PRO O    O  N N 262 
PRO CB   C  N N 263 
PRO CG   C  N N 264 
PRO CD   C  N N 265 
PRO OXT  O  N N 266 
PRO H    H  N N 267 
PRO HA   H  N N 268 
PRO HB2  H  N N 269 
PRO HB3  H  N N 270 
PRO HG2  H  N N 271 
PRO HG3  H  N N 272 
PRO HD2  H  N N 273 
PRO HD3  H  N N 274 
PRO HXT  H  N N 275 
SER N    N  N N 276 
SER CA   C  N S 277 
SER C    C  N N 278 
SER O    O  N N 279 
SER CB   C  N N 280 
SER OG   O  N N 281 
SER OXT  O  N N 282 
SER H    H  N N 283 
SER H2   H  N N 284 
SER HA   H  N N 285 
SER HB2  H  N N 286 
SER HB3  H  N N 287 
SER HG   H  N N 288 
SER HXT  H  N N 289 
THR N    N  N N 290 
THR CA   C  N S 291 
THR C    C  N N 292 
THR O    O  N N 293 
THR CB   C  N R 294 
THR OG1  O  N N 295 
THR CG2  C  N N 296 
THR OXT  O  N N 297 
THR H    H  N N 298 
THR H2   H  N N 299 
THR HA   H  N N 300 
THR HB   H  N N 301 
THR HG1  H  N N 302 
THR HG21 H  N N 303 
THR HG22 H  N N 304 
THR HG23 H  N N 305 
THR HXT  H  N N 306 
TRP N    N  N N 307 
TRP CA   C  N S 308 
TRP C    C  N N 309 
TRP O    O  N N 310 
TRP CB   C  N N 311 
TRP CG   C  Y N 312 
TRP CD1  C  Y N 313 
TRP CD2  C  Y N 314 
TRP NE1  N  Y N 315 
TRP CE2  C  Y N 316 
TRP CE3  C  Y N 317 
TRP CZ2  C  Y N 318 
TRP CZ3  C  Y N 319 
TRP CH2  C  Y N 320 
TRP OXT  O  N N 321 
TRP H    H  N N 322 
TRP H2   H  N N 323 
TRP HA   H  N N 324 
TRP HB2  H  N N 325 
TRP HB3  H  N N 326 
TRP HD1  H  N N 327 
TRP HE1  H  N N 328 
TRP HE3  H  N N 329 
TRP HZ2  H  N N 330 
TRP HZ3  H  N N 331 
TRP HH2  H  N N 332 
TRP HXT  H  N N 333 
TYR N    N  N N 334 
TYR CA   C  N S 335 
TYR C    C  N N 336 
TYR O    O  N N 337 
TYR CB   C  N N 338 
TYR CG   C  Y N 339 
TYR CD1  C  Y N 340 
TYR CD2  C  Y N 341 
TYR CE1  C  Y N 342 
TYR CE2  C  Y N 343 
TYR CZ   C  Y N 344 
TYR OH   O  N N 345 
TYR OXT  O  N N 346 
TYR H    H  N N 347 
TYR H2   H  N N 348 
TYR HA   H  N N 349 
TYR HB2  H  N N 350 
TYR HB3  H  N N 351 
TYR HD1  H  N N 352 
TYR HD2  H  N N 353 
TYR HE1  H  N N 354 
TYR HE2  H  N N 355 
TYR HH   H  N N 356 
TYR HXT  H  N N 357 
VAL N    N  N N 358 
VAL CA   C  N S 359 
VAL C    C  N N 360 
VAL O    O  N N 361 
VAL CB   C  N N 362 
VAL CG1  C  N N 363 
VAL CG2  C  N N 364 
VAL OXT  O  N N 365 
VAL H    H  N N 366 
VAL H2   H  N N 367 
VAL HA   H  N N 368 
VAL HB   H  N N 369 
VAL HG11 H  N N 370 
VAL HG12 H  N N 371 
VAL HG13 H  N N 372 
VAL HG21 H  N N 373 
VAL HG22 H  N N 374 
VAL HG23 H  N N 375 
VAL HXT  H  N N 376 
ZN  ZN   ZN N N 377 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
GLN N   CA   sing N N 70  
GLN N   H    sing N N 71  
GLN N   H2   sing N N 72  
GLN CA  C    sing N N 73  
GLN CA  CB   sing N N 74  
GLN CA  HA   sing N N 75  
GLN C   O    doub N N 76  
GLN C   OXT  sing N N 77  
GLN CB  CG   sing N N 78  
GLN CB  HB2  sing N N 79  
GLN CB  HB3  sing N N 80  
GLN CG  CD   sing N N 81  
GLN CG  HG2  sing N N 82  
GLN CG  HG3  sing N N 83  
GLN CD  OE1  doub N N 84  
GLN CD  NE2  sing N N 85  
GLN NE2 HE21 sing N N 86  
GLN NE2 HE22 sing N N 87  
GLN OXT HXT  sing N N 88  
GLU N   CA   sing N N 89  
GLU N   H    sing N N 90  
GLU N   H2   sing N N 91  
GLU CA  C    sing N N 92  
GLU CA  CB   sing N N 93  
GLU CA  HA   sing N N 94  
GLU C   O    doub N N 95  
GLU C   OXT  sing N N 96  
GLU CB  CG   sing N N 97  
GLU CB  HB2  sing N N 98  
GLU CB  HB3  sing N N 99  
GLU CG  CD   sing N N 100 
GLU CG  HG2  sing N N 101 
GLU CG  HG3  sing N N 102 
GLU CD  OE1  doub N N 103 
GLU CD  OE2  sing N N 104 
GLU OE2 HE2  sing N N 105 
GLU OXT HXT  sing N N 106 
GLY N   CA   sing N N 107 
GLY N   H    sing N N 108 
GLY N   H2   sing N N 109 
GLY CA  C    sing N N 110 
GLY CA  HA2  sing N N 111 
GLY CA  HA3  sing N N 112 
GLY C   O    doub N N 113 
GLY C   OXT  sing N N 114 
GLY OXT HXT  sing N N 115 
HIS N   CA   sing N N 116 
HIS N   H    sing N N 117 
HIS N   H2   sing N N 118 
HIS CA  C    sing N N 119 
HIS CA  CB   sing N N 120 
HIS CA  HA   sing N N 121 
HIS C   O    doub N N 122 
HIS C   OXT  sing N N 123 
HIS CB  CG   sing N N 124 
HIS CB  HB2  sing N N 125 
HIS CB  HB3  sing N N 126 
HIS CG  ND1  sing Y N 127 
HIS CG  CD2  doub Y N 128 
HIS ND1 CE1  doub Y N 129 
HIS ND1 HD1  sing N N 130 
HIS CD2 NE2  sing Y N 131 
HIS CD2 HD2  sing N N 132 
HIS CE1 NE2  sing Y N 133 
HIS CE1 HE1  sing N N 134 
HIS NE2 HE2  sing N N 135 
HIS OXT HXT  sing N N 136 
HOH O   H1   sing N N 137 
HOH O   H2   sing N N 138 
ILE N   CA   sing N N 139 
ILE N   H    sing N N 140 
ILE N   H2   sing N N 141 
ILE CA  C    sing N N 142 
ILE CA  CB   sing N N 143 
ILE CA  HA   sing N N 144 
ILE C   O    doub N N 145 
ILE C   OXT  sing N N 146 
ILE CB  CG1  sing N N 147 
ILE CB  CG2  sing N N 148 
ILE CB  HB   sing N N 149 
ILE CG1 CD1  sing N N 150 
ILE CG1 HG12 sing N N 151 
ILE CG1 HG13 sing N N 152 
ILE CG2 HG21 sing N N 153 
ILE CG2 HG22 sing N N 154 
ILE CG2 HG23 sing N N 155 
ILE CD1 HD11 sing N N 156 
ILE CD1 HD12 sing N N 157 
ILE CD1 HD13 sing N N 158 
ILE OXT HXT  sing N N 159 
LEU N   CA   sing N N 160 
LEU N   H    sing N N 161 
LEU N   H2   sing N N 162 
LEU CA  C    sing N N 163 
LEU CA  CB   sing N N 164 
LEU CA  HA   sing N N 165 
LEU C   O    doub N N 166 
LEU C   OXT  sing N N 167 
LEU CB  CG   sing N N 168 
LEU CB  HB2  sing N N 169 
LEU CB  HB3  sing N N 170 
LEU CG  CD1  sing N N 171 
LEU CG  CD2  sing N N 172 
LEU CG  HG   sing N N 173 
LEU CD1 HD11 sing N N 174 
LEU CD1 HD12 sing N N 175 
LEU CD1 HD13 sing N N 176 
LEU CD2 HD21 sing N N 177 
LEU CD2 HD22 sing N N 178 
LEU CD2 HD23 sing N N 179 
LEU OXT HXT  sing N N 180 
LYS N   CA   sing N N 181 
LYS N   H    sing N N 182 
LYS N   H2   sing N N 183 
LYS CA  C    sing N N 184 
LYS CA  CB   sing N N 185 
LYS CA  HA   sing N N 186 
LYS C   O    doub N N 187 
LYS C   OXT  sing N N 188 
LYS CB  CG   sing N N 189 
LYS CB  HB2  sing N N 190 
LYS CB  HB3  sing N N 191 
LYS CG  CD   sing N N 192 
LYS CG  HG2  sing N N 193 
LYS CG  HG3  sing N N 194 
LYS CD  CE   sing N N 195 
LYS CD  HD2  sing N N 196 
LYS CD  HD3  sing N N 197 
LYS CE  NZ   sing N N 198 
LYS CE  HE2  sing N N 199 
LYS CE  HE3  sing N N 200 
LYS NZ  HZ1  sing N N 201 
LYS NZ  HZ2  sing N N 202 
LYS NZ  HZ3  sing N N 203 
LYS OXT HXT  sing N N 204 
MET N   CA   sing N N 205 
MET N   H    sing N N 206 
MET N   H2   sing N N 207 
MET CA  C    sing N N 208 
MET CA  CB   sing N N 209 
MET CA  HA   sing N N 210 
MET C   O    doub N N 211 
MET C   OXT  sing N N 212 
MET CB  CG   sing N N 213 
MET CB  HB2  sing N N 214 
MET CB  HB3  sing N N 215 
MET CG  SD   sing N N 216 
MET CG  HG2  sing N N 217 
MET CG  HG3  sing N N 218 
MET SD  CE   sing N N 219 
MET CE  HE1  sing N N 220 
MET CE  HE2  sing N N 221 
MET CE  HE3  sing N N 222 
MET OXT HXT  sing N N 223 
PHE N   CA   sing N N 224 
PHE N   H    sing N N 225 
PHE N   H2   sing N N 226 
PHE CA  C    sing N N 227 
PHE CA  CB   sing N N 228 
PHE CA  HA   sing N N 229 
PHE C   O    doub N N 230 
PHE C   OXT  sing N N 231 
PHE CB  CG   sing N N 232 
PHE CB  HB2  sing N N 233 
PHE CB  HB3  sing N N 234 
PHE CG  CD1  doub Y N 235 
PHE CG  CD2  sing Y N 236 
PHE CD1 CE1  sing Y N 237 
PHE CD1 HD1  sing N N 238 
PHE CD2 CE2  doub Y N 239 
PHE CD2 HD2  sing N N 240 
PHE CE1 CZ   doub Y N 241 
PHE CE1 HE1  sing N N 242 
PHE CE2 CZ   sing Y N 243 
PHE CE2 HE2  sing N N 244 
PHE CZ  HZ   sing N N 245 
PHE OXT HXT  sing N N 246 
PRO N   CA   sing N N 247 
PRO N   CD   sing N N 248 
PRO N   H    sing N N 249 
PRO CA  C    sing N N 250 
PRO CA  CB   sing N N 251 
PRO CA  HA   sing N N 252 
PRO C   O    doub N N 253 
PRO C   OXT  sing N N 254 
PRO CB  CG   sing N N 255 
PRO CB  HB2  sing N N 256 
PRO CB  HB3  sing N N 257 
PRO CG  CD   sing N N 258 
PRO CG  HG2  sing N N 259 
PRO CG  HG3  sing N N 260 
PRO CD  HD2  sing N N 261 
PRO CD  HD3  sing N N 262 
PRO OXT HXT  sing N N 263 
SER N   CA   sing N N 264 
SER N   H    sing N N 265 
SER N   H2   sing N N 266 
SER CA  C    sing N N 267 
SER CA  CB   sing N N 268 
SER CA  HA   sing N N 269 
SER C   O    doub N N 270 
SER C   OXT  sing N N 271 
SER CB  OG   sing N N 272 
SER CB  HB2  sing N N 273 
SER CB  HB3  sing N N 274 
SER OG  HG   sing N N 275 
SER OXT HXT  sing N N 276 
THR N   CA   sing N N 277 
THR N   H    sing N N 278 
THR N   H2   sing N N 279 
THR CA  C    sing N N 280 
THR CA  CB   sing N N 281 
THR CA  HA   sing N N 282 
THR C   O    doub N N 283 
THR C   OXT  sing N N 284 
THR CB  OG1  sing N N 285 
THR CB  CG2  sing N N 286 
THR CB  HB   sing N N 287 
THR OG1 HG1  sing N N 288 
THR CG2 HG21 sing N N 289 
THR CG2 HG22 sing N N 290 
THR CG2 HG23 sing N N 291 
THR OXT HXT  sing N N 292 
TRP N   CA   sing N N 293 
TRP N   H    sing N N 294 
TRP N   H2   sing N N 295 
TRP CA  C    sing N N 296 
TRP CA  CB   sing N N 297 
TRP CA  HA   sing N N 298 
TRP C   O    doub N N 299 
TRP C   OXT  sing N N 300 
TRP CB  CG   sing N N 301 
TRP CB  HB2  sing N N 302 
TRP CB  HB3  sing N N 303 
TRP CG  CD1  doub Y N 304 
TRP CG  CD2  sing Y N 305 
TRP CD1 NE1  sing Y N 306 
TRP CD1 HD1  sing N N 307 
TRP CD2 CE2  doub Y N 308 
TRP CD2 CE3  sing Y N 309 
TRP NE1 CE2  sing Y N 310 
TRP NE1 HE1  sing N N 311 
TRP CE2 CZ2  sing Y N 312 
TRP CE3 CZ3  doub Y N 313 
TRP CE3 HE3  sing N N 314 
TRP CZ2 CH2  doub Y N 315 
TRP CZ2 HZ2  sing N N 316 
TRP CZ3 CH2  sing Y N 317 
TRP CZ3 HZ3  sing N N 318 
TRP CH2 HH2  sing N N 319 
TRP OXT HXT  sing N N 320 
TYR N   CA   sing N N 321 
TYR N   H    sing N N 322 
TYR N   H2   sing N N 323 
TYR CA  C    sing N N 324 
TYR CA  CB   sing N N 325 
TYR CA  HA   sing N N 326 
TYR C   O    doub N N 327 
TYR C   OXT  sing N N 328 
TYR CB  CG   sing N N 329 
TYR CB  HB2  sing N N 330 
TYR CB  HB3  sing N N 331 
TYR CG  CD1  doub Y N 332 
TYR CG  CD2  sing Y N 333 
TYR CD1 CE1  sing Y N 334 
TYR CD1 HD1  sing N N 335 
TYR CD2 CE2  doub Y N 336 
TYR CD2 HD2  sing N N 337 
TYR CE1 CZ   doub Y N 338 
TYR CE1 HE1  sing N N 339 
TYR CE2 CZ   sing Y N 340 
TYR CE2 HE2  sing N N 341 
TYR CZ  OH   sing N N 342 
TYR OH  HH   sing N N 343 
TYR OXT HXT  sing N N 344 
VAL N   CA   sing N N 345 
VAL N   H    sing N N 346 
VAL N   H2   sing N N 347 
VAL CA  C    sing N N 348 
VAL CA  CB   sing N N 349 
VAL CA  HA   sing N N 350 
VAL C   O    doub N N 351 
VAL C   OXT  sing N N 352 
VAL CB  CG1  sing N N 353 
VAL CB  CG2  sing N N 354 
VAL CB  HB   sing N N 355 
VAL CG1 HG11 sing N N 356 
VAL CG1 HG12 sing N N 357 
VAL CG1 HG13 sing N N 358 
VAL CG2 HG21 sing N N 359 
VAL CG2 HG22 sing N N 360 
VAL CG2 HG23 sing N N 361 
VAL OXT HXT  sing N N 362 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9LNI 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.028344 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.009495 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014841 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.024110 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
N  
O  
S  
ZN 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . SER A 1 1   ? -14.477 3.838   -1.833  1.00 42.31 ? 2   SER A N   1 
ATOM   2    C  CA  . SER A 1 1   ? -14.186 5.228   -2.164  1.00 44.86 ? 2   SER A CA  1 
ATOM   3    C  C   . SER A 1 1   ? -13.159 5.825   -1.209  1.00 45.98 ? 2   SER A C   1 
ATOM   4    O  O   . SER A 1 1   ? -13.346 5.779   0.002   1.00 43.85 ? 2   SER A O   1 
ATOM   5    C  CB  . SER A 1 1   ? -15.467 6.053   -2.139  1.00 40.68 ? 2   SER A CB  1 
ATOM   6    O  OG  . SER A 1 1   ? -15.340 7.201   -2.953  1.00 48.77 ? 2   SER A OG  1 
ATOM   7    N  N   . LYS A 1 2   ? -12.078 6.386   -1.759  1.00 40.01 ? 3   LYS A N   1 
ATOM   8    C  CA  . LYS A 1 2   ? -11.028 6.953   -0.919  1.00 43.41 ? 3   LYS A CA  1 
ATOM   9    C  C   . LYS A 1 2   ? -11.588 7.989   0.055   1.00 42.86 ? 3   LYS A C   1 
ATOM   10   O  O   . LYS A 1 2   ? -11.207 8.013   1.229   1.00 38.73 ? 3   LYS A O   1 
ATOM   11   C  CB  . LYS A 1 2   ? -9.921  7.550   -1.804  1.00 46.39 ? 3   LYS A CB  1 
ATOM   12   C  CG  . LYS A 1 2   ? -10.003 9.059   -1.998  1.00 50.92 ? 3   LYS A CG  1 
ATOM   13   C  CD  . LYS A 1 2   ? -9.057  9.606   -3.063  1.00 57.31 ? 3   LYS A CD  1 
ATOM   14   C  CE  . LYS A 1 2   ? -7.694  9.990   -2.505  1.00 56.89 ? 3   LYS A CE  1 
ATOM   15   N  NZ  . LYS A 1 2   ? -7.034  10.999  -3.394  1.00 52.13 ? 3   LYS A NZ  1 
ATOM   16   N  N   . GLU A 1 3   ? -12.534 8.818   -0.393  1.00 39.81 ? 4   GLU A N   1 
ATOM   17   C  CA  . GLU A 1 3   ? -13.038 9.861   0.489   1.00 44.67 ? 4   GLU A CA  1 
ATOM   18   C  C   . GLU A 1 3   ? -13.978 9.304   1.545   1.00 41.32 ? 4   GLU A C   1 
ATOM   19   O  O   . GLU A 1 3   ? -13.917 9.722   2.705   1.00 40.60 ? 4   GLU A O   1 
ATOM   20   C  CB  . GLU A 1 3   ? -13.709 10.965  -0.325  1.00 43.09 ? 4   GLU A CB  1 
ATOM   21   C  CG  . GLU A 1 3   ? -13.207 12.331  0.085   1.00 45.90 ? 4   GLU A CG  1 
ATOM   22   C  CD  . GLU A 1 3   ? -11.684 12.427  0.066   1.00 49.51 ? 4   GLU A CD  1 
ATOM   23   O  OE1 . GLU A 1 3   ? -11.023 11.689  -0.698  1.00 52.17 ? 4   GLU A OE1 1 
ATOM   24   O  OE2 . GLU A 1 3   ? -11.136 13.219  0.855   1.00 45.67 ? 4   GLU A OE2 1 
ATOM   25   N  N   . GLU A 1 4   ? -14.834 8.352   1.171   1.00 37.77 ? 5   GLU A N   1 
ATOM   26   C  CA  . GLU A 1 4   ? -15.676 7.693   2.165   1.00 43.14 ? 5   GLU A CA  1 
ATOM   27   C  C   . GLU A 1 4   ? -14.825 6.947   3.179   1.00 37.31 ? 5   GLU A C   1 
ATOM   28   O  O   . GLU A 1 4   ? -15.070 7.027   4.390   1.00 33.60 ? 5   GLU A O   1 
ATOM   29   C  CB  . GLU A 1 4   ? -16.639 6.722   1.484   1.00 39.40 ? 5   GLU A CB  1 
ATOM   30   C  CG  . GLU A 1 4   ? -17.753 7.377   0.689   1.00 50.35 ? 5   GLU A CG  1 
ATOM   31   C  CD  . GLU A 1 4   ? -18.445 6.393   -0.237  1.00 50.85 ? 5   GLU A CD  1 
ATOM   32   O  OE1 . GLU A 1 4   ? -18.410 5.177   0.046   1.00 57.39 ? 5   GLU A OE1 1 
ATOM   33   O  OE2 . GLU A 1 4   ? -19.011 6.827   -1.263  1.00 53.51 ? 5   GLU A OE2 1 
ATOM   34   N  N   . ILE A 1 5   ? -13.820 6.212   2.695   1.00 36.68 ? 6   ILE A N   1 
ATOM   35   C  CA  . ILE A 1 5   ? -12.948 5.452   3.583   1.00 35.08 ? 6   ILE A CA  1 
ATOM   36   C  C   . ILE A 1 5   ? -12.220 6.385   4.530   1.00 36.48 ? 6   ILE A C   1 
ATOM   37   O  O   . ILE A 1 5   ? -12.135 6.125   5.737   1.00 30.09 ? 6   ILE A O   1 
ATOM   38   C  CB  . ILE A 1 5   ? -11.971 4.588   2.762   1.00 36.54 ? 6   ILE A CB  1 
ATOM   39   C  CG1 . ILE A 1 5   ? -12.736 3.502   2.004   1.00 35.65 ? 6   ILE A CG1 1 
ATOM   40   C  CG2 . ILE A 1 5   ? -10.876 3.997   3.656   1.00 38.27 ? 6   ILE A CG2 1 
ATOM   41   C  CD1 . ILE A 1 5   ? -11.852 2.498   1.297   1.00 37.54 ? 6   ILE A CD1 1 
ATOM   42   N  N   . LEU A 1 6   ? -11.688 7.493   4.009   1.00 30.77 ? 7   LEU A N   1 
ATOM   43   C  CA  . LEU A 1 6   ? -11.056 8.449   4.902   1.00 35.05 ? 7   LEU A CA  1 
ATOM   44   C  C   . LEU A 1 6   ? -12.058 8.925   5.943   1.00 31.51 ? 7   LEU A C   1 
ATOM   45   O  O   . LEU A 1 6   ? -11.856 8.691   7.136   1.00 38.86 ? 7   LEU A O   1 
ATOM   46   C  CB  . LEU A 1 6   ? -10.448 9.619   4.121   1.00 35.51 ? 7   LEU A CB  1 
ATOM   47   C  CG  . LEU A 1 6   ? -9.212  9.238   3.283   1.00 34.85 ? 7   LEU A CG  1 
ATOM   48   C  CD1 . LEU A 1 6   ? -8.627  10.428  2.509   1.00 37.52 ? 7   LEU A CD1 1 
ATOM   49   C  CD2 . LEU A 1 6   ? -8.134  8.506   4.094   1.00 31.71 ? 7   LEU A CD2 1 
ATOM   50   N  N   . GLU A 1 7   ? -13.213 9.453   5.508   1.00 32.24 ? 8   GLU A N   1 
ATOM   51   C  CA  . GLU A 1 7   ? -14.207 9.949   6.467   1.00 33.50 ? 8   GLU A CA  1 
ATOM   52   C  C   . GLU A 1 7   ? -14.493 8.935   7.565   1.00 30.54 ? 8   GLU A C   1 
ATOM   53   O  O   . GLU A 1 7   ? -14.570 9.300   8.744   1.00 32.49 ? 8   GLU A O   1 
ATOM   54   C  CB  . GLU A 1 7   ? -15.524 10.312  5.771   1.00 39.35 ? 8   GLU A CB  1 
ATOM   55   C  CG  . GLU A 1 7   ? -15.424 11.313  4.642   1.00 46.68 ? 8   GLU A CG  1 
ATOM   56   C  CD  . GLU A 1 7   ? -16.720 12.071  4.428   1.00 59.62 ? 8   GLU A CD  1 
ATOM   57   O  OE1 . GLU A 1 7   ? -16.662 13.293  4.177   1.00 63.38 ? 8   GLU A OE1 1 
ATOM   58   O  OE2 . GLU A 1 7   ? -17.799 11.441  4.518   1.00 61.20 ? 8   GLU A OE2 1 
ATOM   59   N  N   . GLN A 1 8   ? -14.643 7.658   7.205   1.00 31.13 ? 9   GLN A N   1 
ATOM   60   C  CA  . GLN A 1 8   ? -14.866 6.639   8.230   1.00 25.60 ? 9   GLN A CA  1 
ATOM   61   C  C   . GLN A 1 8   ? -13.682 6.511   9.166   1.00 25.91 ? 9   GLN A C   1 
ATOM   62   O  O   . GLN A 1 8   ? -13.862 6.339   10.376  1.00 29.04 ? 9   GLN A O   1 
ATOM   63   C  CB  . GLN A 1 8   ? -15.188 5.286   7.618   1.00 27.36 ? 9   GLN A CB  1 
ATOM   64   C  CG  . GLN A 1 8   ? -16.239 5.356   6.575   1.00 41.68 ? 9   GLN A CG  1 
ATOM   65   C  CD  . GLN A 1 8   ? -17.207 4.214   6.701   1.00 43.36 ? 9   GLN A CD  1 
ATOM   66   O  OE1 . GLN A 1 8   ? -16.819 3.068   6.929   1.00 45.28 ? 9   GLN A OE1 1 
ATOM   67   N  NE2 . GLN A 1 8   ? -18.486 4.538   6.652   1.00 42.12 ? 9   GLN A NE2 1 
ATOM   68   N  N   . LEU A 1 9   ? -12.468 6.578   8.629   1.00 29.21 ? 10  LEU A N   1 
ATOM   69   C  CA  . LEU A 1 9   ? -11.296 6.464   9.490   1.00 26.60 ? 10  LEU A CA  1 
ATOM   70   C  C   . LEU A 1 9   ? -11.158 7.671   10.424  1.00 31.85 ? 10  LEU A C   1 
ATOM   71   O  O   . LEU A 1 9   ? -10.874 7.498   11.615  1.00 25.23 ? 10  LEU A O   1 
ATOM   72   C  CB  . LEU A 1 9   ? -10.047 6.264   8.635   1.00 22.97 ? 10  LEU A CB  1 
ATOM   73   C  CG  . LEU A 1 9   ? -9.881  4.892   7.972   1.00 26.14 ? 10  LEU A CG  1 
ATOM   74   C  CD1 . LEU A 1 9   ? -8.744  4.924   6.959   1.00 30.27 ? 10  LEU A CD1 1 
ATOM   75   C  CD2 . LEU A 1 9   ? -9.628  3.808   9.027   1.00 28.98 ? 10  LEU A CD2 1 
ATOM   76   N  N   . GLU A 1 10  ? -11.360 8.906   9.931   1.00 25.13 ? 11  GLU A N   1 
ATOM   77   C  CA  . GLU A 1 10  ? -11.346 10.017  10.890  1.00 26.33 ? 11  GLU A CA  1 
ATOM   78   C  C   . GLU A 1 10  ? -12.495 9.922   11.888  1.00 24.58 ? 11  GLU A C   1 
ATOM   79   O  O   . GLU A 1 10  ? -12.341 10.377  13.029  1.00 29.57 ? 11  GLU A O   1 
ATOM   80   C  CB  . GLU A 1 10  ? -11.330 11.429  10.262  1.00 34.76 ? 11  GLU A CB  1 
ATOM   81   C  CG  . GLU A 1 10  ? -10.072 11.920  9.499   1.00 34.11 ? 11  GLU A CG  1 
ATOM   82   C  CD  . GLU A 1 10  ? -10.085 11.664  8.033   1.00 43.35 ? 11  GLU A CD  1 
ATOM   83   O  OE1 . GLU A 1 10  ? -9.448  12.440  7.287   1.00 48.32 ? 11  GLU A OE1 1 
ATOM   84   O  OE2 . GLU A 1 10  ? -10.753 10.735  7.611   1.00 47.70 ? 11  GLU A OE2 1 
ATOM   85   N  N   . LYS A 1 11  ? -13.643 9.352   11.499  1.00 27.48 ? 12  LYS A N   1 
ATOM   86   C  CA  . LYS A 1 11  ? -14.712 9.138   12.478  1.00 29.02 ? 12  LYS A CA  1 
ATOM   87   C  C   . LYS A 1 11  ? -14.248 8.202   13.586  1.00 23.54 ? 12  LYS A C   1 
ATOM   88   O  O   . LYS A 1 11  ? -14.509 8.448   14.774  1.00 27.15 ? 12  LYS A O   1 
ATOM   89   C  CB  . LYS A 1 11  ? -15.958 8.562   11.799  1.00 34.64 ? 12  LYS A CB  1 
ATOM   90   C  CG  . LYS A 1 11  ? -16.993 9.587   11.335  1.00 41.00 ? 12  LYS A CG  1 
ATOM   91   C  CD  . LYS A 1 11  ? -18.217 8.884   10.727  1.00 43.03 ? 12  LYS A CD  1 
ATOM   92   C  CE  . LYS A 1 11  ? -19.526 9.349   11.369  1.00 46.24 ? 12  LYS A CE  1 
ATOM   93   N  NZ  . LYS A 1 11  ? -20.652 9.448   10.380  1.00 41.91 ? 12  LYS A NZ  1 
ATOM   94   N  N   . MET A 1 12  ? -13.553 7.130   13.204  1.00 24.87 ? 13  MET A N   1 
ATOM   95   C  CA  . MET A 1 12  ? -13.044 6.179   14.186  1.00 24.27 ? 13  MET A CA  1 
ATOM   96   C  C   . MET A 1 12  ? -11.993 6.820   15.080  1.00 26.42 ? 13  MET A C   1 
ATOM   97   O  O   . MET A 1 12  ? -11.934 6.535   16.284  1.00 20.54 ? 13  MET A O   1 
ATOM   98   C  CB  . MET A 1 12  ? -12.488 4.943   13.486  1.00 22.85 ? 13  MET A CB  1 
ATOM   99   C  CG  . MET A 1 12  ? -13.544 4.131   12.792  1.00 31.95 ? 13  MET A CG  1 
ATOM   100  S  SD  . MET A 1 12  ? -12.821 2.831   11.793  1.00 32.34 ? 13  MET A SD  1 
ATOM   101  C  CE  . MET A 1 12  ? -12.234 1.746   13.087  1.00 31.20 ? 13  MET A CE  1 
ATOM   102  N  N   . VAL A 1 13  ? -11.151 7.679   14.505  1.00 22.26 ? 14  VAL A N   1 
ATOM   103  C  CA  . VAL A 1 13  ? -10.168 8.405   15.303  1.00 22.79 ? 14  VAL A CA  1 
ATOM   104  C  C   . VAL A 1 13  ? -10.867 9.305   16.308  1.00 23.61 ? 14  VAL A C   1 
ATOM   105  O  O   . VAL A 1 13  ? -10.477 9.370   17.471  1.00 21.90 ? 14  VAL A O   1 
ATOM   106  C  CB  . VAL A 1 13  ? -9.213  9.202   14.390  1.00 20.79 ? 14  VAL A CB  1 
ATOM   107  C  CG1 . VAL A 1 13  ? -8.353  10.146  15.217  1.00 24.41 ? 14  VAL A CG1 1 
ATOM   108  C  CG2 . VAL A 1 13  ? -8.350  8.255   13.572  1.00 21.33 ? 14  VAL A CG2 1 
ATOM   109  N  N   . GLU A 1 14  ? -11.902 10.031  15.872  1.00 23.03 ? 15  GLU A N   1 
ATOM   110  C  CA  . GLU A 1 14  ? -12.594 10.939  16.780  1.00 23.71 ? 15  GLU A CA  1 
ATOM   111  C  C   . GLU A 1 14  ? -13.253 10.179  17.923  1.00 22.71 ? 15  GLU A C   1 
ATOM   112  O  O   . GLU A 1 14  ? -13.218 10.623  19.078  1.00 22.89 ? 15  GLU A O   1 
ATOM   113  C  CB  . GLU A 1 14  ? -13.635 11.744  16.007  1.00 31.36 ? 15  GLU A CB  1 
ATOM   114  C  CG  . GLU A 1 14  ? -13.024 12.758  15.085  1.00 36.28 ? 15  GLU A CG  1 
ATOM   115  C  CD  . GLU A 1 14  ? -12.389 13.902  15.845  1.00 40.65 ? 15  GLU A CD  1 
ATOM   116  O  OE1 . GLU A 1 14  ? -13.096 14.530  16.658  1.00 50.07 ? 15  GLU A OE1 1 
ATOM   117  O  OE2 . GLU A 1 14  ? -11.183 14.170  15.634  1.00 47.66 ? 15  GLU A OE2 1 
ATOM   118  N  N   . GLU A 1 15  ? -13.870 9.041   17.606  1.00 24.98 ? 16  GLU A N   1 
ATOM   119  C  CA  . GLU A 1 15  ? -14.511 8.227   18.636  1.00 25.32 ? 16  GLU A CA  1 
ATOM   120  C  C   . GLU A 1 15  ? -13.487 7.702   19.630  1.00 26.38 ? 16  GLU A C   1 
ATOM   121  O  O   . GLU A 1 15  ? -13.724 7.725   20.847  1.00 23.69 ? 16  GLU A O   1 
ATOM   122  C  CB  . GLU A 1 15  ? -15.272 7.068   18.002  1.00 25.11 ? 16  GLU A CB  1 
ATOM   123  C  CG  . GLU A 1 15  ? -15.790 6.054   19.034  1.00 33.79 ? 16  GLU A CG  1 
ATOM   124  C  CD  . GLU A 1 15  ? -16.518 4.880   18.397  1.00 44.29 ? 16  GLU A CD  1 
ATOM   125  O  OE1 . GLU A 1 15  ? -16.171 4.506   17.262  1.00 49.21 ? 16  GLU A OE1 1 
ATOM   126  O  OE2 . GLU A 1 15  ? -17.420 4.313   19.049  1.00 48.51 ? 16  GLU A OE2 1 
ATOM   127  N  N   . ALA A 1 16  ? -12.333 7.242   19.126  1.00 26.51 ? 17  ALA A N   1 
ATOM   128  C  CA  . ALA A 1 16  ? -11.275 6.768   20.014  1.00 20.79 ? 17  ALA A CA  1 
ATOM   129  C  C   . ALA A 1 16  ? -10.754 7.889   20.903  1.00 24.18 ? 17  ALA A C   1 
ATOM   130  O  O   . ALA A 1 16  ? -10.481 7.666   22.078  1.00 20.43 ? 17  ALA A O   1 
ATOM   131  C  CB  . ALA A 1 16  ? -10.136 6.151   19.200  1.00 22.81 ? 17  ALA A CB  1 
ATOM   132  N  N   . LYS A 1 17  ? -10.604 9.104   20.358  1.00 22.94 ? 18  LYS A N   1 
ATOM   133  C  CA  . LYS A 1 17  ? -10.184 10.238  21.182  1.00 19.81 ? 18  LYS A CA  1 
ATOM   134  C  C   . LYS A 1 17  ? -11.210 10.537  22.266  1.00 18.24 ? 18  LYS A C   1 
ATOM   135  O  O   . LYS A 1 17  ? -10.848 10.867  23.407  1.00 26.37 ? 18  LYS A O   1 
ATOM   136  C  CB  . LYS A 1 17  ? -9.979  11.482  20.312  1.00 23.41 ? 18  LYS A CB  1 
ATOM   137  C  CG  . LYS A 1 17  ? -8.691  11.470  19.514  1.00 25.15 ? 18  LYS A CG  1 
ATOM   138  C  CD  . LYS A 1 17  ? -8.557  12.764  18.703  1.00 25.00 ? 18  LYS A CD  1 
ATOM   139  C  CE  . LYS A 1 17  ? -7.258  12.781  17.901  1.00 28.99 ? 18  LYS A CE  1 
ATOM   140  N  NZ  . LYS A 1 17  ? -7.193  14.027  17.068  1.00 31.29 ? 18  LYS A NZ  1 
ATOM   141  N  N   . GLU A 1 18  ? -12.496 10.464  21.906  1.00 22.35 ? 19  GLU A N   1 
ATOM   142  C  CA  . GLU A 1 18  ? -13.561 10.683  22.873  1.00 26.51 ? 19  GLU A CA  1 
ATOM   143  C  C   . GLU A 1 18  ? -13.490 9.661   24.000  1.00 21.45 ? 19  GLU A C   1 
ATOM   144  O  O   . GLU A 1 18  ? -13.622 10.021  25.172  1.00 28.38 ? 19  GLU A O   1 
ATOM   145  C  CB  . GLU A 1 18  ? -14.915 10.653  22.142  1.00 31.25 ? 19  GLU A CB  1 
ATOM   146  C  CG  . GLU A 1 18  ? -16.157 10.255  22.971  1.00 40.08 ? 19  GLU A CG  1 
ATOM   147  C  CD  . GLU A 1 18  ? -16.446 8.739   23.010  1.00 39.89 ? 19  GLU A CD  1 
ATOM   148  O  OE1 . GLU A 1 18  ? -16.820 8.236   24.097  1.00 45.35 ? 19  GLU A OE1 1 
ATOM   149  O  OE2 . GLU A 1 18  ? -16.355 8.059   21.952  1.00 35.98 ? 19  GLU A OE2 1 
ATOM   150  N  N   . GLU A 1 19  ? -13.224 8.390   23.674  1.00 23.25 ? 20  GLU A N   1 
ATOM   151  C  CA  . GLU A 1 19  ? -13.154 7.377   24.732  1.00 20.14 ? 20  GLU A CA  1 
ATOM   152  C  C   . GLU A 1 19  ? -11.916 7.572   25.593  1.00 22.59 ? 20  GLU A C   1 
ATOM   153  O  O   . GLU A 1 19  ? -11.956 7.356   26.812  1.00 25.78 ? 20  GLU A O   1 
ATOM   154  C  CB  . GLU A 1 19  ? -13.155 5.959   24.168  1.00 23.05 ? 20  GLU A CB  1 
ATOM   155  C  CG  . GLU A 1 19  ? -14.467 5.554   23.540  1.00 27.72 ? 20  GLU A CG  1 
ATOM   156  C  CD  . GLU A 1 19  ? -14.425 4.192   22.874  1.00 33.57 ? 20  GLU A CD  1 
ATOM   157  O  OE1 . GLU A 1 19  ? -13.401 3.468   22.972  1.00 27.70 ? 20  GLU A OE1 1 
ATOM   158  O  OE2 . GLU A 1 19  ? -15.413 3.870   22.178  1.00 36.56 ? 20  GLU A OE2 1 
ATOM   159  N  N   . LEU A 1 20  ? -10.800 7.950   24.970  1.00 23.49 ? 21  LEU A N   1 
ATOM   160  C  CA  . LEU A 1 20  ? -9.578  8.186   25.728  1.00 24.52 ? 21  LEU A CA  1 
ATOM   161  C  C   . LEU A 1 20  ? -9.732  9.360   26.682  1.00 28.88 ? 21  LEU A C   1 
ATOM   162  O  O   . LEU A 1 20  ? -9.203  9.332   27.796  1.00 29.30 ? 21  LEU A O   1 
ATOM   163  C  CB  . LEU A 1 20  ? -8.408  8.394   24.762  1.00 27.17 ? 21  LEU A CB  1 
ATOM   164  C  CG  . LEU A 1 20  ? -7.037  8.473   25.424  1.00 25.02 ? 21  LEU A CG  1 
ATOM   165  C  CD1 . LEU A 1 20  ? -6.695  7.255   26.270  1.00 26.10 ? 21  LEU A CD1 1 
ATOM   166  C  CD2 . LEU A 1 20  ? -6.037  8.626   24.298  1.00 26.94 ? 21  LEU A CD2 1 
ATOM   167  N  N   . LYS A 1 21  ? -10.470 10.392  26.271  1.00 23.48 ? 22  LYS A N   1 
ATOM   168  C  CA  . LYS A 1 21  ? -10.717 11.527  27.150  1.00 30.11 ? 22  LYS A CA  1 
ATOM   169  C  C   . LYS A 1 21  ? -11.479 11.130  28.404  1.00 34.25 ? 22  LYS A C   1 
ATOM   170  O  O   . LYS A 1 21  ? -11.271 11.722  29.468  1.00 38.37 ? 22  LYS A O   1 
ATOM   171  C  CB  . LYS A 1 21  ? -11.505 12.603  26.416  1.00 34.71 ? 22  LYS A CB  1 
ATOM   172  C  CG  . LYS A 1 21  ? -11.712 13.819  27.287  1.00 40.77 ? 22  LYS A CG  1 
ATOM   173  C  CD  . LYS A 1 21  ? -12.545 14.832  26.586  1.00 43.63 ? 22  LYS A CD  1 
ATOM   174  C  CE  . LYS A 1 21  ? -14.005 14.387  26.521  1.00 44.49 ? 22  LYS A CE  1 
ATOM   175  N  NZ  . LYS A 1 21  ? -14.872 15.268  27.350  1.00 48.12 ? 22  LYS A NZ  1 
ATOM   176  N  N   . LYS A 1 22  ? -12.387 10.164  28.295  1.00 26.82 ? 23  LYS A N   1 
ATOM   177  C  CA  . LYS A 1 22  ? -13.138 9.656   29.440  1.00 29.90 ? 23  LYS A CA  1 
ATOM   178  C  C   . LYS A 1 22  ? -12.236 8.721   30.248  1.00 33.67 ? 23  LYS A C   1 
ATOM   179  O  O   . LYS A 1 22  ? -12.482 7.524   30.392  1.00 43.39 ? 23  LYS A O   1 
ATOM   180  C  CB  . LYS A 1 22  ? -14.407 8.954   28.976  1.00 35.48 ? 23  LYS A CB  1 
ATOM   181  C  CG  . LYS A 1 22  ? -15.295 9.793   28.070  1.00 36.91 ? 23  LYS A CG  1 
ATOM   182  C  CD  . LYS A 1 22  ? -16.773 9.433   28.257  1.00 46.05 ? 23  LYS A CD  1 
ATOM   183  C  CE  . LYS A 1 22  ? -17.171 8.218   27.421  1.00 44.77 ? 23  LYS A CE  1 
ATOM   184  N  NZ  . LYS A 1 22  ? -18.471 8.380   26.683  1.00 47.33 ? 23  LYS A NZ  1 
ATOM   185  N  N   . ALA A 1 23  ? -11.163 9.304   30.787  1.00 36.90 ? 24  ALA A N   1 
ATOM   186  C  CA  . ALA A 1 23  ? -10.090 8.544   31.412  1.00 32.21 ? 24  ALA A CA  1 
ATOM   187  C  C   . ALA A 1 23  ? -10.113 8.563   32.933  1.00 32.26 ? 24  ALA A C   1 
ATOM   188  O  O   . ALA A 1 23  ? -9.414  7.751   33.547  1.00 32.33 ? 24  ALA A O   1 
ATOM   189  C  CB  . ALA A 1 23  ? -8.731  9.068   30.937  1.00 35.71 ? 24  ALA A CB  1 
ATOM   190  N  N   . LYS A 1 24  ? -10.891 9.450   33.552  1.00 35.26 ? 25  LYS A N   1 
ATOM   191  C  CA  . LYS A 1 24  ? -10.830 9.608   35.004  1.00 43.59 ? 25  LYS A CA  1 
ATOM   192  C  C   . LYS A 1 24  ? -11.038 8.279   35.728  1.00 37.68 ? 25  LYS A C   1 
ATOM   193  O  O   . LYS A 1 24  ? -10.254 7.912   36.612  1.00 42.13 ? 25  LYS A O   1 
ATOM   194  C  CB  . LYS A 1 24  ? -11.865 10.638  35.463  1.00 42.11 ? 25  LYS A CB  1 
ATOM   195  N  N   . ASP A 1 25  ? -12.070 7.530   35.347  1.00 33.53 ? 26  ASP A N   1 
ATOM   196  C  CA  . ASP A 1 25  ? -12.416 6.282   36.014  1.00 36.08 ? 26  ASP A CA  1 
ATOM   197  C  C   . ASP A 1 25  ? -11.845 5.045   35.326  1.00 35.51 ? 26  ASP A C   1 
ATOM   198  O  O   . ASP A 1 25  ? -12.258 3.927   35.651  1.00 36.00 ? 26  ASP A O   1 
ATOM   199  C  CB  . ASP A 1 25  ? -13.941 6.169   36.157  1.00 41.39 ? 26  ASP A CB  1 
ATOM   200  C  CG  . ASP A 1 25  ? -14.662 6.078   34.818  1.00 43.76 ? 26  ASP A CG  1 
ATOM   201  O  OD1 . ASP A 1 25  ? -13.985 6.031   33.767  1.00 36.90 ? 26  ASP A OD1 1 
ATOM   202  O  OD2 . ASP A 1 25  ? -15.917 6.064   34.821  1.00 36.82 ? 26  ASP A OD2 1 
ATOM   203  N  N   . LYS A 1 26  ? -10.903 5.210   34.397  1.00 29.13 ? 27  LYS A N   1 
ATOM   204  C  CA  . LYS A 1 26  ? -10.289 4.069   33.733  1.00 28.42 ? 27  LYS A CA  1 
ATOM   205  C  C   . LYS A 1 26  ? -9.020  3.639   34.466  1.00 22.89 ? 27  LYS A C   1 
ATOM   206  O  O   . LYS A 1 26  ? -8.290  4.472   35.013  1.00 28.12 ? 27  LYS A O   1 
ATOM   207  C  CB  . LYS A 1 26  ? -9.981  4.395   32.260  1.00 24.31 ? 27  LYS A CB  1 
ATOM   208  C  CG  . LYS A 1 26  ? -11.106 3.939   31.315  1.00 28.93 ? 27  LYS A CG  1 
ATOM   209  C  CD  . LYS A 1 26  ? -11.153 4.680   29.974  1.00 33.46 ? 27  LYS A CD  1 
ATOM   210  C  CE  . LYS A 1 26  ? -12.576 4.635   29.404  1.00 32.79 ? 27  LYS A CE  1 
ATOM   211  N  NZ  . LYS A 1 26  ? -12.652 4.585   27.930  1.00 38.19 ? 27  LYS A NZ  1 
ATOM   212  N  N   . SER A 1 27  ? -8.783  2.326   34.496  1.00 21.77 ? 28  SER A N   1 
ATOM   213  C  CA  . SER A 1 27  ? -7.550  1.801   35.065  1.00 23.20 ? 28  SER A CA  1 
ATOM   214  C  C   . SER A 1 27  ? -6.393  2.099   34.116  1.00 21.57 ? 28  SER A C   1 
ATOM   215  O  O   . SER A 1 27  ? -6.612  2.353   32.931  1.00 21.44 ? 28  SER A O   1 
ATOM   216  C  CB  . SER A 1 27  ? -7.656  0.295   35.281  1.00 23.77 ? 28  SER A CB  1 
ATOM   217  O  OG  . SER A 1 27  ? -7.619  -0.392  34.039  1.00 22.10 ? 28  SER A OG  1 
ATOM   218  N  N   . PRO A 1 28  ? -5.147  2.048   34.603  1.00 18.22 ? 29  PRO A N   1 
ATOM   219  C  CA  . PRO A 1 28  ? -4.011  2.254   33.689  1.00 19.06 ? 29  PRO A CA  1 
ATOM   220  C  C   . PRO A 1 28  ? -4.017  1.299   32.509  1.00 17.60 ? 29  PRO A C   1 
ATOM   221  O  O   . PRO A 1 28  ? -3.685  1.723   31.397  1.00 17.52 ? 29  PRO A O   1 
ATOM   222  C  CB  . PRO A 1 28  ? -2.791  2.025   34.591  1.00 20.91 ? 29  PRO A CB  1 
ATOM   223  C  CG  . PRO A 1 28  ? -3.282  2.419   35.964  1.00 24.29 ? 29  PRO A CG  1 
ATOM   224  C  CD  . PRO A 1 28  ? -4.725  2.021   36.020  1.00 23.14 ? 29  PRO A CD  1 
ATOM   225  N  N   . LEU A 1 29  ? -4.357  0.023   32.722  1.00 17.55 ? 30  LEU A N   1 
ATOM   226  C  CA  . LEU A 1 29  ? -4.359  -0.938  31.615  1.00 16.26 ? 30  LEU A CA  1 
ATOM   227  C  C   . LEU A 1 29  ? -5.427  -0.595  30.580  1.00 17.53 ? 30  LEU A C   1 
ATOM   228  O  O   . LEU A 1 29  ? -5.191  -0.720  29.366  1.00 18.61 ? 30  LEU A O   1 
ATOM   229  C  CB  . LEU A 1 29  ? -4.560  -2.355  32.144  1.00 20.05 ? 30  LEU A CB  1 
ATOM   230  C  CG  . LEU A 1 29  ? -3.342  -2.967  32.822  1.00 23.22 ? 30  LEU A CG  1 
ATOM   231  C  CD1 . LEU A 1 29  ? -3.742  -4.292  33.408  1.00 23.97 ? 30  LEU A CD1 1 
ATOM   232  C  CD2 . LEU A 1 29  ? -2.218  -3.147  31.830  1.00 21.51 ? 30  LEU A CD2 1 
ATOM   233  N  N   . GLU A 1 30  ? -6.610  -0.204  31.032  1.00 19.96 ? 31  GLU A N   1 
ATOM   234  C  CA  . GLU A 1 30  ? -7.634  0.255   30.095  1.00 17.71 ? 31  GLU A CA  1 
ATOM   235  C  C   . GLU A 1 30  ? -7.179  1.499   29.345  1.00 18.46 ? 31  GLU A C   1 
ATOM   236  O  O   . GLU A 1 30  ? -7.426  1.621   28.138  1.00 20.25 ? 31  GLU A O   1 
ATOM   237  C  CB  . GLU A 1 30  ? -8.940  0.489   30.850  1.00 24.86 ? 31  GLU A CB  1 
ATOM   238  C  CG  . GLU A 1 30  ? -9.370  -0.776  31.577  1.00 21.41 ? 31  GLU A CG  1 
ATOM   239  C  CD  . GLU A 1 30  ? -10.606 -0.621  32.446  1.00 31.12 ? 31  GLU A CD  1 
ATOM   240  O  OE1 . GLU A 1 30  ? -10.937 0.519   32.830  1.00 31.06 ? 31  GLU A OE1 1 
ATOM   241  O  OE2 . GLU A 1 30  ? -11.210 -1.664  32.802  1.00 34.69 ? 31  GLU A OE2 1 
ATOM   242  N  N   . LEU A 1 31  ? -6.491  2.420   30.032  1.00 17.17 ? 32  LEU A N   1 
ATOM   243  C  CA  . LEU A 1 31  ? -5.966  3.606   29.354  1.00 17.37 ? 32  LEU A CA  1 
ATOM   244  C  C   . LEU A 1 31  ? -4.928  3.225   28.308  1.00 16.15 ? 32  LEU A C   1 
ATOM   245  O  O   . LEU A 1 31  ? -4.902  3.793   27.207  1.00 16.83 ? 32  LEU A O   1 
ATOM   246  C  CB  . LEU A 1 31  ? -5.356  4.560   30.375  1.00 18.13 ? 32  LEU A CB  1 
ATOM   247  C  CG  . LEU A 1 31  ? -6.382  5.582   30.833  1.00 28.62 ? 32  LEU A CG  1 
ATOM   248  C  CD1 . LEU A 1 31  ? -6.045  6.058   32.230  1.00 28.00 ? 32  LEU A CD1 1 
ATOM   249  C  CD2 . LEU A 1 31  ? -6.406  6.731   29.831  1.00 33.90 ? 32  LEU A CD2 1 
ATOM   250  N  N   . ILE A 1 32  ? -4.057  2.265   28.633  1.00 15.59 ? 33  ILE A N   1 
ATOM   251  C  CA  . ILE A 1 32  ? -3.061  1.817   27.668  1.00 16.28 ? 33  ILE A CA  1 
ATOM   252  C  C   . ILE A 1 32  ? -3.754  1.177   26.474  1.00 17.30 ? 33  ILE A C   1 
ATOM   253  O  O   . ILE A 1 32  ? -3.355  1.390   25.322  1.00 17.94 ? 33  ILE A O   1 
ATOM   254  C  CB  . ILE A 1 32  ? -2.056  0.870   28.340  1.00 16.01 ? 33  ILE A CB  1 
ATOM   255  C  CG1 . ILE A 1 32  ? -1.188  1.684   29.291  1.00 17.82 ? 33  ILE A CG1 1 
ATOM   256  C  CG2 . ILE A 1 32  ? -1.208  0.162   27.277  1.00 18.10 ? 33  ILE A CG2 1 
ATOM   257  C  CD1 . ILE A 1 32  ? -0.382  0.818   30.256  1.00 18.41 ? 33  ILE A CD1 1 
ATOM   258  N  N   . LEU A 1 33  ? -4.818  0.406   26.729  1.00 16.33 ? 34  LEU A N   1 
ATOM   259  C  CA  . LEU A 1 33  ? -5.599  -0.180  25.637  1.00 15.78 ? 34  LEU A CA  1 
ATOM   260  C  C   . LEU A 1 33  ? -6.187  0.898   24.739  1.00 19.29 ? 34  LEU A C   1 
ATOM   261  O  O   . LEU A 1 33  ? -6.092  0.813   23.503  1.00 19.54 ? 34  LEU A O   1 
ATOM   262  C  CB  . LEU A 1 33  ? -6.715  -1.048  26.220  1.00 16.45 ? 34  LEU A CB  1 
ATOM   263  C  CG  . LEU A 1 33  ? -7.635  -1.695  25.173  1.00 21.30 ? 34  LEU A CG  1 
ATOM   264  C  CD1 . LEU A 1 33  ? -6.829  -2.614  24.287  1.00 23.38 ? 34  LEU A CD1 1 
ATOM   265  C  CD2 . LEU A 1 33  ? -8.801  -2.438  25.872  1.00 21.35 ? 34  LEU A CD2 1 
ATOM   266  N  N   . GLU A 1 34  ? -6.795  1.931   25.339  1.00 18.72 ? 35  GLU A N   1 
ATOM   267  C  CA  . GLU A 1 34  ? -7.356  3.029   24.541  1.00 14.34 ? 35  GLU A CA  1 
ATOM   268  C  C   . GLU A 1 34  ? -6.277  3.719   23.730  1.00 19.90 ? 35  GLU A C   1 
ATOM   269  O  O   . GLU A 1 34  ? -6.505  4.118   22.585  1.00 17.28 ? 35  GLU A O   1 
ATOM   270  C  CB  . GLU A 1 34  ? -8.050  4.083   25.425  1.00 18.71 ? 35  GLU A CB  1 
ATOM   271  C  CG  . GLU A 1 34  ? -9.250  3.607   26.237  1.00 19.78 ? 35  GLU A CG  1 
ATOM   272  C  CD  . GLU A 1 34  ? -10.473 3.370   25.352  1.00 24.76 ? 35  GLU A CD  1 
ATOM   273  O  OE1 . GLU A 1 34  ? -10.397 3.563   24.115  1.00 24.82 ? 35  GLU A OE1 1 
ATOM   274  O  OE2 . GLU A 1 34  ? -11.488 2.950   25.910  1.00 24.87 ? 35  GLU A OE2 1 
ATOM   275  N  N   . THR A 1 35  ? -5.109  3.925   24.336  1.00 14.38 ? 36  THR A N   1 
ATOM   276  C  CA  . THR A 1 35  ? -4.073  4.728   23.699  1.00 16.50 ? 36  THR A CA  1 
ATOM   277  C  C   . THR A 1 35  ? -3.451  3.999   22.524  1.00 18.92 ? 36  THR A C   1 
ATOM   278  O  O   . THR A 1 35  ? -3.180  4.600   21.471  1.00 19.59 ? 36  THR A O   1 
ATOM   279  C  CB  . THR A 1 35  ? -3.002  5.065   24.736  1.00 20.78 ? 36  THR A CB  1 
ATOM   280  O  OG1 . THR A 1 35  ? -3.602  5.798   25.800  1.00 17.75 ? 36  THR A OG1 1 
ATOM   281  C  CG2 . THR A 1 35  ? -1.907  5.899   24.107  1.00 23.20 ? 36  THR A CG2 1 
ATOM   282  N  N   . LEU A 1 36  ? -3.169  2.721   22.688  1.00 17.41 ? 37  LEU A N   1 
ATOM   283  C  CA  . LEU A 1 36  ? -2.552  2.044   21.565  1.00 21.09 ? 37  LEU A CA  1 
ATOM   284  C  C   . LEU A 1 36  ? -3.594  1.706   20.506  1.00 20.67 ? 37  LEU A C   1 
ATOM   285  O  O   . LEU A 1 36  ? -3.247  1.724   19.327  1.00 17.74 ? 37  LEU A O   1 
ATOM   286  C  CB  . LEU A 1 36  ? -1.707  0.886   22.093  1.00 26.86 ? 37  LEU A CB  1 
ATOM   287  C  CG  . LEU A 1 36  ? -0.419  1.622   22.515  1.00 28.22 ? 37  LEU A CG  1 
ATOM   288  C  CD1 . LEU A 1 36  ? 0.095   1.284   23.898  1.00 28.24 ? 37  LEU A CD1 1 
ATOM   289  C  CD2 . LEU A 1 36  ? 0.676   1.392   21.471  1.00 31.67 ? 37  LEU A CD2 1 
ATOM   290  N  N   . THR A 1 37  ? -4.885  1.587   20.863  1.00 17.87 ? 38  THR A N   1 
ATOM   291  C  CA  . THR A 1 37  ? -5.920  1.569   19.820  1.00 22.44 ? 38  THR A CA  1 
ATOM   292  C  C   . THR A 1 37  ? -5.920  2.879   19.023  1.00 18.41 ? 38  THR A C   1 
ATOM   293  O  O   . THR A 1 37  ? -5.953  2.881   17.775  1.00 16.34 ? 38  THR A O   1 
ATOM   294  C  CB  . THR A 1 37  ? -7.302  1.332   20.440  1.00 22.50 ? 38  THR A CB  1 
ATOM   295  O  OG1 . THR A 1 37  ? -7.323  0.059   21.107  1.00 19.18 ? 38  THR A OG1 1 
ATOM   296  C  CG2 . THR A 1 37  ? -8.380  1.332   19.360  1.00 25.58 ? 38  THR A CG2 1 
ATOM   297  N  N   . LEU A 1 38  ? -5.873  4.011   19.717  1.00 15.21 ? 39  LEU A N   1 
ATOM   298  C  CA  . LEU A 1 38  ? -5.847  5.280   18.983  1.00 14.82 ? 39  LEU A CA  1 
ATOM   299  C  C   . LEU A 1 38  ? -4.603  5.407   18.112  1.00 13.18 ? 39  LEU A C   1 
ATOM   300  O  O   . LEU A 1 38  ? -4.687  5.857   16.960  1.00 15.34 ? 39  LEU A O   1 
ATOM   301  C  CB  . LEU A 1 38  ? -5.923  6.450   19.942  1.00 15.01 ? 39  LEU A CB  1 
ATOM   302  C  CG  . LEU A 1 38  ? -5.723  7.823   19.298  1.00 14.25 ? 39  LEU A CG  1 
ATOM   303  C  CD1 . LEU A 1 38  ? -6.717  8.119   18.160  1.00 15.96 ? 39  LEU A CD1 1 
ATOM   304  C  CD2 . LEU A 1 38  ? -5.915  8.858   20.419  1.00 20.98 ? 39  LEU A CD2 1 
ATOM   305  N  N   . ILE A 1 39  ? -3.432  5.062   18.645  1.00 13.43 ? 40  ILE A N   1 
ATOM   306  C  CA  . ILE A 1 39  ? -2.209  5.230   17.868  1.00 13.45 ? 40  ILE A CA  1 
ATOM   307  C  C   . ILE A 1 39  ? -2.215  4.290   16.664  1.00 13.11 ? 40  ILE A C   1 
ATOM   308  O  O   . ILE A 1 39  ? -1.720  4.654   15.584  1.00 14.80 ? 40  ILE A O   1 
ATOM   309  C  CB  . ILE A 1 39  ? -0.977  5.023   18.771  1.00 14.88 ? 40  ILE A CB  1 
ATOM   310  C  CG1 . ILE A 1 39  ? -0.904  6.191   19.746  1.00 14.31 ? 40  ILE A CG1 1 
ATOM   311  C  CG2 . ILE A 1 39  ? 0.283   4.879   17.893  1.00 19.94 ? 40  ILE A CG2 1 
ATOM   312  C  CD1 . ILE A 1 39  ? 0.138   6.022   20.870  1.00 17.46 ? 40  ILE A CD1 1 
ATOM   313  N  N   . THR A 1 40  ? -2.768  3.072   16.820  1.00 12.91 ? 41  THR A N   1 
ATOM   314  C  CA  . THR A 1 40  ? -2.926  2.175   15.682  1.00 11.47 ? 41  THR A CA  1 
ATOM   315  C  C   . THR A 1 40  ? -3.819  2.814   14.628  1.00 14.15 ? 41  THR A C   1 
ATOM   316  O  O   . THR A 1 40  ? -3.508  2.746   13.430  1.00 17.03 ? 41  THR A O   1 
ATOM   317  C  CB  . THR A 1 40  ? -3.496  0.820   16.104  1.00 19.27 ? 41  THR A CB  1 
ATOM   318  O  OG1 . THR A 1 40  ? -2.620  0.163   17.036  1.00 17.52 ? 41  THR A OG1 1 
ATOM   319  C  CG2 . THR A 1 40  ? -3.683  -0.095  14.863  1.00 13.16 ? 41  THR A CG2 1 
ATOM   320  N  N   . LEU A 1 41  ? -4.925  3.439   15.054  1.00 16.10 ? 42  LEU A N   1 
ATOM   321  C  CA  . LEU A 1 41  ? -5.803  4.122   14.097  1.00 14.07 ? 42  LEU A CA  1 
ATOM   322  C  C   . LEU A 1 41  ? -5.092  5.292   13.426  1.00 19.40 ? 42  LEU A C   1 
ATOM   323  O  O   . LEU A 1 41  ? -5.224  5.495   12.212  1.00 17.58 ? 42  LEU A O   1 
ATOM   324  C  CB  . LEU A 1 41  ? -7.082  4.605   14.791  1.00 16.22 ? 42  LEU A CB  1 
ATOM   325  C  CG  . LEU A 1 41  ? -8.049  3.539   15.311  1.00 22.30 ? 42  LEU A CG  1 
ATOM   326  C  CD1 . LEU A 1 41  ? -9.249  4.195   16.055  1.00 19.65 ? 42  LEU A CD1 1 
ATOM   327  C  CD2 . LEU A 1 41  ? -8.527  2.608   14.243  1.00 22.49 ? 42  LEU A CD2 1 
ATOM   328  N  N   . LEU A 1 42  ? -4.345  6.089   14.194  1.00 15.45 ? 43  LEU A N   1 
ATOM   329  C  CA  . LEU A 1 42  ? -3.632  7.232   13.617  1.00 13.58 ? 43  LEU A CA  1 
ATOM   330  C  C   . LEU A 1 42  ? -2.622  6.790   12.563  1.00 18.14 ? 43  LEU A C   1 
ATOM   331  O  O   . LEU A 1 42  ? -2.541  7.382   11.481  1.00 17.40 ? 43  LEU A O   1 
ATOM   332  C  CB  . LEU A 1 42  ? -2.922  7.999   14.723  1.00 15.85 ? 43  LEU A CB  1 
ATOM   333  C  CG  . LEU A 1 42  ? -3.840  8.797   15.651  1.00 14.39 ? 43  LEU A CG  1 
ATOM   334  C  CD1 . LEU A 1 42  ? -3.008  9.283   16.802  1.00 15.61 ? 43  LEU A CD1 1 
ATOM   335  C  CD2 . LEU A 1 42  ? -4.471  10.011  14.948  1.00 19.58 ? 43  LEU A CD2 1 
ATOM   336  N  N   . SER A 1 43  ? -1.848  5.742   12.863  1.00 16.54 ? 44  SER A N   1 
ATOM   337  C  CA  . SER A 1 43  ? -0.874  5.236   11.901  1.00 14.10 ? 44  SER A CA  1 
ATOM   338  C  C   . SER A 1 43  ? -1.538  4.563   10.709  1.00 21.28 ? 44  SER A C   1 
ATOM   339  O  O   . SER A 1 43  ? -1.063  4.723   9.576   1.00 16.79 ? 44  SER A O   1 
ATOM   340  C  CB  . SER A 1 43  ? 0.131   4.356   12.649  1.00 18.02 ? 44  SER A CB  1 
ATOM   341  O  OG  . SER A 1 43  ? -0.497  3.247   13.265  1.00 14.44 ? 44  SER A OG  1 
ATOM   342  N  N   . LEU A 1 44  ? -2.679  3.905   10.910  1.00 16.58 ? 45  LEU A N   1 
ATOM   343  C  CA  . LEU A 1 44  ? -3.413  3.363   9.757   1.00 16.21 ? 45  LEU A CA  1 
ATOM   344  C  C   . LEU A 1 44  ? -3.952  4.483   8.862   1.00 16.34 ? 45  LEU A C   1 
ATOM   345  O  O   . LEU A 1 44  ? -3.895  4.374   7.620   1.00 20.15 ? 45  LEU A O   1 
ATOM   346  C  CB  . LEU A 1 44  ? -4.540  2.462   10.247  1.00 18.39 ? 45  LEU A CB  1 
ATOM   347  C  CG  . LEU A 1 44  ? -4.153  1.073   10.768  1.00 16.53 ? 45  LEU A CG  1 
ATOM   348  C  CD1 . LEU A 1 44  ? -5.383  0.427   11.347  1.00 16.75 ? 45  LEU A CD1 1 
ATOM   349  C  CD2 . LEU A 1 44  ? -3.559  0.229   9.631   1.00 20.25 ? 45  LEU A CD2 1 
ATOM   350  N  N   . LEU A 1 45  ? -4.458  5.560   9.459   1.00 16.29 ? 46  LEU A N   1 
ATOM   351  C  CA  . LEU A 1 45  ? -4.908  6.716   8.678   1.00 19.49 ? 46  LEU A CA  1 
ATOM   352  C  C   . LEU A 1 45  ? -3.753  7.342   7.900   1.00 21.68 ? 46  LEU A C   1 
ATOM   353  O  O   . LEU A 1 45  ? -3.922  7.752   6.737   1.00 21.49 ? 46  LEU A O   1 
ATOM   354  C  CB  . LEU A 1 45  ? -5.568  7.742   9.600   1.00 19.08 ? 46  LEU A CB  1 
ATOM   355  C  CG  . LEU A 1 45  ? -6.039  9.000   8.881   1.00 16.75 ? 46  LEU A CG  1 
ATOM   356  C  CD1 . LEU A 1 45  ? -7.008  8.644   7.741   1.00 25.95 ? 46  LEU A CD1 1 
ATOM   357  C  CD2 . LEU A 1 45  ? -6.680  9.947   9.898   1.00 23.49 ? 46  LEU A CD2 1 
ATOM   358  N  N   . ALA A 1 46  ? -2.566  7.420   8.506   1.00 19.14 ? 47  ALA A N   1 
ATOM   359  C  CA  . ALA A 1 46  ? -1.419  7.971   7.780   1.00 20.75 ? 47  ALA A CA  1 
ATOM   360  C  C   . ALA A 1 46  ? -1.033  7.091   6.588   1.00 21.66 ? 47  ALA A C   1 
ATOM   361  O  O   . ALA A 1 46  ? -0.692  7.601   5.507   1.00 21.42 ? 47  ALA A O   1 
ATOM   362  C  CB  . ALA A 1 46  ? -0.227  8.151   8.720   1.00 19.30 ? 47  ALA A CB  1 
ATOM   363  N  N   . ILE A 1 47  ? -1.061  5.773   6.760   1.00 16.14 ? 48  ILE A N   1 
ATOM   364  C  CA  . ILE A 1 47  ? -0.797  4.853   5.651   1.00 18.26 ? 48  ILE A CA  1 
ATOM   365  C  C   . ILE A 1 47  ? -1.821  5.067   4.540   1.00 25.36 ? 48  ILE A C   1 
ATOM   366  O  O   . ILE A 1 47  ? -1.484  5.075   3.342   1.00 23.97 ? 48  ILE A O   1 
ATOM   367  C  CB  . ILE A 1 47  ? -0.813  3.403   6.169   1.00 22.96 ? 48  ILE A CB  1 
ATOM   368  C  CG1 . ILE A 1 47  ? 0.362   3.151   7.119   1.00 17.55 ? 48  ILE A CG1 1 
ATOM   369  C  CG2 . ILE A 1 47  ? -0.817  2.411   5.003   1.00 22.12 ? 48  ILE A CG2 1 
ATOM   370  C  CD1 . ILE A 1 47  ? 0.205   1.882   7.975   1.00 19.71 ? 48  ILE A CD1 1 
ATOM   371  N  N   . ALA A 1 48  ? -3.084  5.258   4.922   1.00 23.44 ? 49  ALA A N   1 
ATOM   372  C  CA  . ALA A 1 48  ? -4.156  5.438   3.944   1.00 24.22 ? 49  ALA A CA  1 
ATOM   373  C  C   . ALA A 1 48  ? -3.974  6.717   3.137   1.00 24.38 ? 49  ALA A C   1 
ATOM   374  O  O   . ALA A 1 48  ? -4.163  6.714   1.913   1.00 33.52 ? 49  ALA A O   1 
ATOM   375  C  CB  . ALA A 1 48  ? -5.506  5.458   4.652   1.00 25.04 ? 49  ALA A CB  1 
ATOM   376  N  N   . LYS A 1 49  ? -3.615  7.817   3.797   1.00 25.06 ? 50  LYS A N   1 
ATOM   377  C  CA  . LYS A 1 49  ? -3.524  9.088   3.080   1.00 25.69 ? 50  LYS A CA  1 
ATOM   378  C  C   . LYS A 1 49  ? -2.245  9.234   2.256   1.00 30.13 ? 50  LYS A C   1 
ATOM   379  O  O   . LYS A 1 49  ? -2.265  9.942   1.247   1.00 32.76 ? 50  LYS A O   1 
ATOM   380  C  CB  . LYS A 1 49  ? -3.659  10.262  4.043   1.00 28.67 ? 50  LYS A CB  1 
ATOM   381  C  CG  . LYS A 1 49  ? -5.095  10.521  4.463   1.00 32.86 ? 50  LYS A CG  1 
ATOM   382  C  CD  . LYS A 1 49  ? -5.255  11.886  5.118   1.00 40.90 ? 50  LYS A CD  1 
ATOM   383  C  CE  . LYS A 1 49  ? -6.718  12.291  5.172   1.00 44.65 ? 50  LYS A CE  1 
ATOM   384  N  NZ  . LYS A 1 49  ? -7.107  12.870  6.488   1.00 46.42 ? 50  LYS A NZ  1 
ATOM   385  N  N   . GLU A 1 50  ? -1.134  8.613   2.658   1.00 27.46 ? 51  GLU A N   1 
ATOM   386  C  CA  . GLU A 1 50  ? 0.126   8.674   1.905   1.00 30.45 ? 51  GLU A CA  1 
ATOM   387  C  C   . GLU A 1 50  ? 0.519   10.114  1.547   1.00 31.91 ? 51  GLU A C   1 
ATOM   388  O  O   . GLU A 1 50  ? 0.833   10.434  0.397   1.00 28.54 ? 51  GLU A O   1 
ATOM   389  C  CB  . GLU A 1 50  ? 0.029   7.815   0.645   1.00 29.56 ? 51  GLU A CB  1 
ATOM   390  C  CG  . GLU A 1 50  ? 0.630   6.429   0.760   1.00 35.49 ? 51  GLU A CG  1 
ATOM   391  C  CD  . GLU A 1 50  ? 0.587   5.684   -0.567  1.00 44.01 ? 51  GLU A CD  1 
ATOM   392  O  OE1 . GLU A 1 50  ? 1.629   5.630   -1.262  1.00 51.56 ? 51  GLU A OE1 1 
ATOM   393  O  OE2 . GLU A 1 50  ? -0.490  5.141   -0.906  1.00 41.79 ? 51  GLU A OE2 1 
ATOM   394  N  N   . ASP A 1 51  ? 0.507   10.991  2.549   1.00 25.93 ? 52  ASP A N   1 
ATOM   395  C  CA  . ASP A 1 51  ? 0.641   12.430  2.350   1.00 24.49 ? 52  ASP A CA  1 
ATOM   396  C  C   . ASP A 1 51  ? 1.629   13.007  3.359   1.00 28.68 ? 52  ASP A C   1 
ATOM   397  O  O   . ASP A 1 51  ? 1.475   12.797  4.564   1.00 23.74 ? 52  ASP A O   1 
ATOM   398  C  CB  . ASP A 1 51  ? -0.738  13.094  2.472   1.00 26.55 ? 52  ASP A CB  1 
ATOM   399  C  CG  . ASP A 1 51  ? -0.683  14.588  2.355   1.00 35.89 ? 52  ASP A CG  1 
ATOM   400  O  OD1 . ASP A 1 51  ? -0.471  15.108  1.239   1.00 34.46 ? 52  ASP A OD1 1 
ATOM   401  O  OD2 . ASP A 1 51  ? -0.870  15.244  3.388   1.00 32.88 ? 52  ASP A OD2 1 
ATOM   402  N  N   . GLU A 1 52  ? 2.620   13.764  2.875   1.00 29.53 ? 53  GLU A N   1 
ATOM   403  C  CA  . GLU A 1 52  ? 3.752   14.153  3.723   1.00 26.58 ? 53  GLU A CA  1 
ATOM   404  C  C   . GLU A 1 52  ? 3.306   14.925  4.965   1.00 27.08 ? 53  GLU A C   1 
ATOM   405  O  O   . GLU A 1 52  ? 3.690   14.587  6.104   1.00 26.65 ? 53  GLU A O   1 
ATOM   406  C  CB  . GLU A 1 52  ? 4.752   14.988  2.917   1.00 27.62 ? 53  GLU A CB  1 
ATOM   407  C  CG  . GLU A 1 52  ? 6.169   14.570  3.198   1.00 41.44 ? 53  GLU A CG  1 
ATOM   408  C  CD  . GLU A 1 52  ? 6.583   13.403  2.319   1.00 48.95 ? 53  GLU A CD  1 
ATOM   409  O  OE1 . GLU A 1 52  ? 6.925   13.630  1.135   1.00 51.51 ? 53  GLU A OE1 1 
ATOM   410  O  OE2 . GLU A 1 52  ? 6.517   12.248  2.803   1.00 54.08 ? 53  GLU A OE2 1 
ATOM   411  N  N   . GLU A 1 53  ? 2.484   15.965  4.771   1.00 25.87 ? 54  GLU A N   1 
ATOM   412  C  CA  . GLU A 1 53  ? 2.092   16.786  5.912   1.00 27.07 ? 54  GLU A CA  1 
ATOM   413  C  C   . GLU A 1 53  ? 1.143   16.020  6.829   1.00 25.68 ? 54  GLU A C   1 
ATOM   414  O  O   . GLU A 1 53  ? 1.095   16.301  8.032   1.00 22.28 ? 54  GLU A O   1 
ATOM   415  C  CB  . GLU A 1 53  ? 1.466   18.113  5.444   1.00 31.02 ? 54  GLU A CB  1 
ATOM   416  C  CG  . GLU A 1 53  ? 0.115   18.002  4.747   1.00 26.04 ? 54  GLU A CG  1 
ATOM   417  C  CD  . GLU A 1 53  ? 0.215   17.857  3.228   1.00 27.81 ? 54  GLU A CD  1 
ATOM   418  O  OE1 . GLU A 1 53  ? 1.251   17.368  2.750   1.00 26.95 ? 54  GLU A OE1 1 
ATOM   419  O  OE2 . GLU A 1 53  ? -0.778  18.155  2.522   1.00 33.28 ? 54  GLU A OE2 1 
ATOM   420  N  N   . THR A 1 54  ? 0.413   15.032  6.289   1.00 21.51 ? 55  THR A N   1 
ATOM   421  C  CA  . THR A 1 54  ? -0.409  14.169  7.140   1.00 24.81 ? 55  THR A CA  1 
ATOM   422  C  C   . THR A 1 54  ? 0.454   13.280  8.017   1.00 22.98 ? 55  THR A C   1 
ATOM   423  O  O   . THR A 1 54  ? 0.158   13.093  9.207   1.00 20.63 ? 55  THR A O   1 
ATOM   424  C  CB  . THR A 1 54  ? -1.354  13.322  6.295   1.00 23.81 ? 55  THR A CB  1 
ATOM   425  O  OG1 . THR A 1 54  ? -2.236  14.186  5.569   1.00 25.32 ? 55  THR A OG1 1 
ATOM   426  C  CG2 . THR A 1 54  ? -2.182  12.386  7.178   1.00 27.36 ? 55  THR A CG2 1 
ATOM   427  N  N   . TRP A 1 55  ? 1.514   12.707  7.450   1.00 22.54 ? 56  TRP A N   1 
ATOM   428  C  CA  A TRP A 1 55  ? 2.416   11.925  8.278   0.03 21.06 ? 56  TRP A CA  1 
ATOM   429  C  CA  B TRP A 1 55  ? 2.467   11.936  8.248   0.97 20.74 ? 56  TRP A CA  1 
ATOM   430  C  C   . TRP A 1 55  ? 2.979   12.765  9.415   1.00 23.13 ? 56  TRP A C   1 
ATOM   431  O  O   . TRP A 1 55  ? 3.023   12.300  10.563  1.00 21.69 ? 56  TRP A O   1 
ATOM   432  C  CB  A TRP A 1 55  ? 3.527   11.313  7.429   0.03 23.38 ? 56  TRP A CB  1 
ATOM   433  C  CB  B TRP A 1 55  ? 3.651   11.481  7.391   0.97 23.35 ? 56  TRP A CB  1 
ATOM   434  C  CG  A TRP A 1 55  ? 3.663   9.871   7.730   0.03 23.50 ? 56  TRP A CG  1 
ATOM   435  C  CG  B TRP A 1 55  ? 3.409   10.276  6.573   0.97 21.44 ? 56  TRP A CG  1 
ATOM   436  C  CD1 A TRP A 1 55  ? 4.140   9.323   8.880   0.03 23.52 ? 56  TRP A CD1 1 
ATOM   437  C  CD1 B TRP A 1 55  ? 3.249   10.224  5.216   0.97 23.36 ? 56  TRP A CD1 1 
ATOM   438  C  CD2 A TRP A 1 55  ? 3.224   8.779   6.918   0.03 22.80 ? 56  TRP A CD2 1 
ATOM   439  C  CD2 B TRP A 1 55  ? 3.273   8.935   7.049   0.97 22.08 ? 56  TRP A CD2 1 
ATOM   440  N  NE1 A TRP A 1 55  ? 4.076   7.955   8.818   0.03 23.20 ? 56  TRP A NE1 1 
ATOM   441  N  NE1 B TRP A 1 55  ? 3.037   8.917   4.816   0.97 27.24 ? 56  TRP A NE1 1 
ATOM   442  C  CE2 A TRP A 1 55  ? 3.512   7.595   7.623   0.03 23.21 ? 56  TRP A CE2 1 
ATOM   443  C  CE2 B TRP A 1 55  ? 3.040   8.111   5.928   0.97 25.83 ? 56  TRP A CE2 1 
ATOM   444  C  CE3 A TRP A 1 55  ? 2.640   8.686   5.652   0.03 24.27 ? 56  TRP A CE3 1 
ATOM   445  C  CE3 B TRP A 1 55  ? 3.327   8.346   8.321   0.97 24.66 ? 56  TRP A CE3 1 
ATOM   446  C  CZ2 A TRP A 1 55  ? 3.233   6.337   7.109   0.03 23.17 ? 56  TRP A CZ2 1 
ATOM   447  C  CZ2 B TRP A 1 55  ? 2.860   6.723   6.043   0.97 24.09 ? 56  TRP A CZ2 1 
ATOM   448  C  CZ3 A TRP A 1 55  ? 2.364   7.436   5.145   0.03 23.99 ? 56  TRP A CZ3 1 
ATOM   449  C  CZ3 B TRP A 1 55  ? 3.151   6.964   8.425   0.97 24.33 ? 56  TRP A CZ3 1 
ATOM   450  C  CH2 A TRP A 1 55  ? 2.656   6.279   5.875   0.03 23.47 ? 56  TRP A CH2 1 
ATOM   451  C  CH2 B TRP A 1 55  ? 2.928   6.178   7.293   0.97 24.85 ? 56  TRP A CH2 1 
ATOM   452  N  N   . LYS A 1 56  ? 3.361   14.018  9.134   1.00 22.84 ? 57  LYS A N   1 
ATOM   453  C  CA  . LYS A 1 56  ? 3.901   14.867  10.197  1.00 20.49 ? 57  LYS A CA  1 
ATOM   454  C  C   . LYS A 1 56  ? 2.865   15.110  11.293  1.00 22.51 ? 57  LYS A C   1 
ATOM   455  O  O   . LYS A 1 56  ? 3.161   14.970  12.496  1.00 22.21 ? 57  LYS A O   1 
ATOM   456  C  CB  . LYS A 1 56  ? 4.390   16.197  9.611   1.00 28.05 ? 57  LYS A CB  1 
ATOM   457  C  CG  . LYS A 1 56  ? 4.622   17.286  10.651  1.00 26.68 ? 57  LYS A CG  1 
ATOM   458  C  CD  . LYS A 1 56  ? 5.229   18.550  10.058  1.00 35.22 ? 57  LYS A CD  1 
ATOM   459  C  CE  . LYS A 1 56  ? 4.380   19.081  8.923   1.00 40.34 ? 57  LYS A CE  1 
ATOM   460  N  NZ  . LYS A 1 56  ? 3.030   19.465  9.410   1.00 42.79 ? 57  LYS A NZ  1 
ATOM   461  N  N   . LYS A 1 57  ? 1.628   15.442  10.904  1.00 18.48 ? 58  LYS A N   1 
ATOM   462  C  CA  . LYS A 1 57  ? 0.626   15.810  11.909  1.00 21.63 ? 58  LYS A CA  1 
ATOM   463  C  C   . LYS A 1 57  ? 0.157   14.606  12.721  1.00 18.76 ? 58  LYS A C   1 
ATOM   464  O  O   . LYS A 1 57  ? -0.059  14.720  13.936  1.00 19.83 ? 58  LYS A O   1 
ATOM   465  C  CB  . LYS A 1 57  ? -0.544  16.545  11.247  1.00 27.90 ? 58  LYS A CB  1 
ATOM   466  C  CG  . LYS A 1 57  ? -1.771  15.729  10.902  1.00 28.83 ? 58  LYS A CG  1 
ATOM   467  C  CD  . LYS A 1 57  ? -3.056  16.508  11.201  1.00 31.87 ? 58  LYS A CD  1 
ATOM   468  C  CE  . LYS A 1 57  ? -4.287  15.755  10.711  1.00 37.71 ? 58  LYS A CE  1 
ATOM   469  N  NZ  . LYS A 1 57  ? -5.194  15.383  11.845  1.00 40.16 ? 58  LYS A NZ  1 
ATOM   470  N  N   . LEU A 1 58  ? 0.009   13.441  12.076  1.00 17.69 ? 59  LEU A N   1 
ATOM   471  C  CA  . LEU A 1 58  ? -0.456  12.266  12.808  1.00 16.87 ? 59  LEU A CA  1 
ATOM   472  C  C   . LEU A 1 58  ? 0.650   11.685  13.670  1.00 19.70 ? 59  LEU A C   1 
ATOM   473  O  O   . LEU A 1 58  ? 0.360   11.151  14.752  1.00 15.87 ? 59  LEU A O   1 
ATOM   474  C  CB  . LEU A 1 58  ? -1.027  11.202  11.850  1.00 17.30 ? 59  LEU A CB  1 
ATOM   475  C  CG  . LEU A 1 58  ? -2.319  11.672  11.127  1.00 19.92 ? 59  LEU A CG  1 
ATOM   476  C  CD1 . LEU A 1 58  ? -2.913  10.626  10.195  1.00 21.93 ? 59  LEU A CD1 1 
ATOM   477  C  CD2 . LEU A 1 58  ? -3.368  12.191  12.115  1.00 23.23 ? 59  LEU A CD2 1 
ATOM   478  N  N   . LEU A 1 59  ? 1.911   11.808  13.253  1.00 18.90 ? 60  LEU A N   1 
ATOM   479  C  CA  . LEU A 1 59  ? 2.997   11.471  14.162  1.00 18.14 ? 60  LEU A CA  1 
ATOM   480  C  C   . LEU A 1 59  ? 2.957   12.372  15.391  1.00 17.70 ? 60  LEU A C   1 
ATOM   481  O  O   . LEU A 1 59  ? 3.076   11.894  16.534  1.00 15.91 ? 60  LEU A O   1 
ATOM   482  C  CB  . LEU A 1 59  ? 4.337   11.595  13.445  1.00 20.38 ? 60  LEU A CB  1 
ATOM   483  C  CG  . LEU A 1 59  ? 5.545   11.576  14.371  1.00 19.90 ? 60  LEU A CG  1 
ATOM   484  C  CD1 . LEU A 1 59  ? 5.572   10.248  15.146  1.00 18.10 ? 60  LEU A CD1 1 
ATOM   485  C  CD2 . LEU A 1 59  ? 6.830   11.776  13.597  1.00 25.36 ? 60  LEU A CD2 1 
ATOM   486  N  N   . GLU A 1 60  ? 2.767   13.685  15.185  1.00 15.71 ? 61  GLU A N   1 
ATOM   487  C  CA  . GLU A 1 60  ? 2.656   14.584  16.338  1.00 16.30 ? 61  GLU A CA  1 
ATOM   488  C  C   . GLU A 1 60  ? 1.526   14.158  17.255  1.00 19.12 ? 61  GLU A C   1 
ATOM   489  O  O   . GLU A 1 60  ? 1.691   14.139  18.483  1.00 20.18 ? 61  GLU A O   1 
ATOM   490  C  CB  . GLU A 1 60  ? 2.447   16.038  15.898  1.00 24.56 ? 61  GLU A CB  1 
ATOM   491  C  CG  . GLU A 1 60  ? 3.600   16.649  15.184  1.00 30.14 ? 61  GLU A CG  1 
ATOM   492  C  CD  . GLU A 1 60  ? 3.352   18.113  14.835  1.00 34.83 ? 61  GLU A CD  1 
ATOM   493  O  OE1 . GLU A 1 60  ? 2.182   18.506  14.647  1.00 36.65 ? 61  GLU A OE1 1 
ATOM   494  O  OE2 . GLU A 1 60  ? 4.338   18.864  14.780  1.00 35.59 ? 61  GLU A OE2 1 
ATOM   495  N  N   . GLU A 1 61  ? 0.377   13.788  16.678  1.00 18.85 ? 62  GLU A N   1 
ATOM   496  C  CA  . GLU A 1 61  ? -0.771  13.432  17.506  1.00 16.64 ? 62  GLU A CA  1 
ATOM   497  C  C   . GLU A 1 61  ? -0.512  12.154  18.283  1.00 16.59 ? 62  GLU A C   1 
ATOM   498  O  O   . GLU A 1 61  ? -0.903  12.063  19.454  1.00 19.06 ? 62  GLU A O   1 
ATOM   499  C  CB  . GLU A 1 61  ? -2.027  13.297  16.650  1.00 23.31 ? 62  GLU A CB  1 
ATOM   500  C  CG  . GLU A 1 61  ? -2.376  14.605  15.962  1.00 23.93 ? 62  GLU A CG  1 
ATOM   501  C  CD  . GLU A 1 61  ? -3.779  14.652  15.436  1.00 32.79 ? 62  GLU A CD  1 
ATOM   502  O  OE1 . GLU A 1 61  ? -4.530  13.664  15.606  1.00 34.25 ? 62  GLU A OE1 1 
ATOM   503  O  OE2 . GLU A 1 61  ? -4.105  15.680  14.807  1.00 36.24 ? 62  GLU A OE2 1 
ATOM   504  N  N   . ALA A 1 62  ? 0.122   11.163  17.641  1.00 16.91 ? 63  ALA A N   1 
ATOM   505  C  CA  . ALA A 1 62  ? 0.477   9.911   18.315  1.00 13.71 ? 63  ALA A CA  1 
ATOM   506  C  C   . ALA A 1 62  ? 1.436   10.173  19.467  1.00 16.27 ? 63  ALA A C   1 
ATOM   507  O  O   . ALA A 1 62  ? 1.306   9.581   20.548  1.00 16.82 ? 63  ALA A O   1 
ATOM   508  C  CB  . ALA A 1 62  ? 1.118   8.943   17.304  1.00 15.88 ? 63  ALA A CB  1 
ATOM   509  N  N   . LEU A 1 63  ? 2.437   11.014  19.239  1.00 15.60 ? 64  LEU A N   1 
ATOM   510  C  CA  . LEU A 1 63  ? 3.412   11.283  20.295  1.00 14.36 ? 64  LEU A CA  1 
ATOM   511  C  C   . LEU A 1 63  ? 2.752   12.010  21.458  1.00 17.44 ? 64  LEU A C   1 
ATOM   512  O  O   . LEU A 1 63  ? 3.016   11.694  22.628  1.00 17.86 ? 64  LEU A O   1 
ATOM   513  C  CB  . LEU A 1 63  ? 4.567   12.105  19.726  1.00 17.69 ? 64  LEU A CB  1 
ATOM   514  C  CG  . LEU A 1 63  ? 5.481   11.411  18.702  1.00 19.05 ? 64  LEU A CG  1 
ATOM   515  C  CD1 . LEU A 1 63  ? 6.418   12.438  18.074  1.00 19.26 ? 64  LEU A CD1 1 
ATOM   516  C  CD2 . LEU A 1 63  ? 6.297   10.281  19.316  1.00 16.44 ? 64  LEU A CD2 1 
ATOM   517  N  N   . GLU A 1 64  ? 1.867   12.968  21.148  1.00 17.16 ? 65  GLU A N   1 
ATOM   518  C  CA  . GLU A 1 64  ? 1.124   13.697  22.176  1.00 18.94 ? 65  GLU A CA  1 
ATOM   519  C  C   . GLU A 1 64  ? 0.245   12.766  22.998  1.00 18.97 ? 65  GLU A C   1 
ATOM   520  O  O   . GLU A 1 64  ? 0.207   12.865  24.235  1.00 23.15 ? 65  GLU A O   1 
ATOM   521  C  CB  . GLU A 1 64  ? 0.266   14.770  21.512  1.00 23.08 ? 65  GLU A CB  1 
ATOM   522  N  N   . THR A 1 65  ? -0.479  11.859  22.334  1.00 18.91 ? 66  THR A N   1 
ATOM   523  C  CA  A THR A 1 65  ? -1.362  10.931  23.043  0.57 19.27 ? 66  THR A CA  1 
ATOM   524  C  CA  B THR A 1 65  ? -1.364  10.989  23.096  0.43 19.30 ? 66  THR A CA  1 
ATOM   525  C  C   . THR A 1 65  ? -0.561  10.011  23.945  1.00 21.10 ? 66  THR A C   1 
ATOM   526  O  O   . THR A 1 65  ? -0.939  9.759   25.091  1.00 16.55 ? 66  THR A O   1 
ATOM   527  C  CB  A THR A 1 65  ? -2.171  10.081  22.058  0.57 23.70 ? 66  THR A CB  1 
ATOM   528  C  CB  B THR A 1 65  ? -2.373  10.273  22.185  0.43 25.22 ? 66  THR A CB  1 
ATOM   529  O  OG1 A THR A 1 65  ? -1.279  9.327   21.237  0.57 29.05 ? 66  THR A OG1 1 
ATOM   530  O  OG1 B THR A 1 65  ? -3.341  9.588   22.997  0.43 23.01 ? 66  THR A OG1 1 
ATOM   531  C  CG2 A THR A 1 65  ? -3.049  10.935  21.184  0.57 17.19 ? 66  THR A CG2 1 
ATOM   532  C  CG2 B THR A 1 65  ? -1.713  9.279   21.292  0.43 25.37 ? 66  THR A CG2 1 
ATOM   533  N  N   . ALA A 1 66  ? 0.563   9.491   23.429  1.00 17.31 ? 67  ALA A N   1 
ATOM   534  C  CA  . ALA A 1 66  ? 1.400   8.605   24.240  1.00 14.59 ? 67  ALA A CA  1 
ATOM   535  C  C   . ALA A 1 66  ? 1.938   9.332   25.467  1.00 19.49 ? 67  ALA A C   1 
ATOM   536  O  O   . ALA A 1 66  ? 1.907   8.791   26.583  1.00 17.25 ? 67  ALA A O   1 
ATOM   537  C  CB  . ALA A 1 66  ? 2.551   8.044   23.390  1.00 19.00 ? 67  ALA A CB  1 
ATOM   538  N  N   . GLU A 1 67  ? 2.441   10.555  25.287  1.00 18.27 ? 68  GLU A N   1 
ATOM   539  C  CA  . GLU A 1 67  ? 3.004   11.273  26.427  1.00 18.56 ? 68  GLU A CA  1 
ATOM   540  C  C   . GLU A 1 67  ? 1.934   11.547  27.474  1.00 19.40 ? 68  GLU A C   1 
ATOM   541  O  O   . GLU A 1 67  ? 2.178   11.384  28.681  1.00 17.68 ? 68  GLU A O   1 
ATOM   542  C  CB  . GLU A 1 67  ? 3.660   12.570  25.961  1.00 20.65 ? 68  GLU A CB  1 
ATOM   543  C  CG  . GLU A 1 67  ? 3.946   13.539  27.100  1.00 24.32 ? 68  GLU A CG  1 
ATOM   544  C  CD  . GLU A 1 67  ? 5.004   14.549  26.738  1.00 34.06 ? 68  GLU A CD  1 
ATOM   545  O  OE1 . GLU A 1 67  ? 5.211   14.820  25.533  1.00 36.31 ? 68  GLU A OE1 1 
ATOM   546  O  OE2 . GLU A 1 67  ? 5.668   15.046  27.668  1.00 36.42 ? 68  GLU A OE2 1 
ATOM   547  N  N   . GLU A 1 68  ? 0.738   11.950  27.033  1.00 17.83 ? 69  GLU A N   1 
ATOM   548  C  CA  . GLU A 1 68  ? -0.324  12.272  27.983  1.00 20.70 ? 69  GLU A CA  1 
ATOM   549  C  C   . GLU A 1 68  ? -0.727  11.037  28.784  1.00 19.59 ? 69  GLU A C   1 
ATOM   550  O  O   . GLU A 1 68  ? -0.883  11.101  30.015  1.00 18.35 ? 69  GLU A O   1 
ATOM   551  C  CB  . GLU A 1 68  ? -1.513  12.858  27.225  1.00 24.09 ? 69  GLU A CB  1 
ATOM   552  C  CG  . GLU A 1 68  ? -1.428  14.373  27.051  1.00 32.45 ? 69  GLU A CG  1 
ATOM   553  C  CD  . GLU A 1 68  ? -2.145  14.870  25.797  1.00 43.83 ? 69  GLU A CD  1 
ATOM   554  O  OE1 . GLU A 1 68  ? -2.968  14.113  25.228  1.00 40.92 ? 69  GLU A OE1 1 
ATOM   555  O  OE2 . GLU A 1 68  ? -1.875  16.018  25.371  1.00 48.31 ? 69  GLU A OE2 1 
ATOM   556  N  N   . THR A 1 69  ? -0.864  9.892   28.112  1.00 16.93 ? 70  THR A N   1 
ATOM   557  C  CA  . THR A 1 69  ? -1.218  8.678   28.840  1.00 15.68 ? 70  THR A CA  1 
ATOM   558  C  C   . THR A 1 69  ? -0.121  8.254   29.800  1.00 17.11 ? 70  THR A C   1 
ATOM   559  O  O   . THR A 1 69  ? -0.413  7.862   30.937  1.00 17.59 ? 70  THR A O   1 
ATOM   560  C  CB  . THR A 1 69  ? -1.542  7.558   27.867  1.00 16.57 ? 70  THR A CB  1 
ATOM   561  O  OG1 . THR A 1 69  ? -2.801  7.852   27.272  1.00 17.95 ? 70  THR A OG1 1 
ATOM   562  C  CG2 . THR A 1 69  ? -1.625  6.236   28.583  1.00 21.12 ? 70  THR A CG2 1 
ATOM   563  N  N   . LEU A 1 70  ? 1.140   8.307   29.366  1.00 18.00 ? 71  LEU A N   1 
ATOM   564  C  CA  . LEU A 1 70  ? 2.230   7.876   30.232  1.00 16.35 ? 71  LEU A CA  1 
ATOM   565  C  C   . LEU A 1 70  ? 2.278   8.740   31.482  1.00 20.92 ? 71  LEU A C   1 
ATOM   566  O  O   . LEU A 1 70  ? 2.491   8.222   32.584  1.00 19.03 ? 71  LEU A O   1 
ATOM   567  C  CB  . LEU A 1 70  ? 3.553   7.923   29.480  1.00 17.49 ? 71  LEU A CB  1 
ATOM   568  C  CG  . LEU A 1 70  ? 3.692   6.842   28.418  1.00 18.96 ? 71  LEU A CG  1 
ATOM   569  C  CD1 . LEU A 1 70  ? 4.939   7.139   27.638  1.00 19.58 ? 71  LEU A CD1 1 
ATOM   570  C  CD2 . LEU A 1 70  ? 3.746   5.441   29.019  1.00 19.87 ? 71  LEU A CD2 1 
ATOM   571  N  N   . LYS A 1 71  ? 2.059   10.057  31.331  1.00 19.20 ? 72  LYS A N   1 
ATOM   572  C  CA  . LYS A 1 71  ? 1.976   10.933  32.505  1.00 17.15 ? 72  LYS A CA  1 
ATOM   573  C  C   . LYS A 1 71  ? 0.835   10.521  33.417  1.00 25.04 ? 72  LYS A C   1 
ATOM   574  O  O   . LYS A 1 71  ? 1.008   10.452  34.642  1.00 27.01 ? 72  LYS A O   1 
ATOM   575  C  CB  . LYS A 1 71  ? 1.804   12.385  32.093  1.00 22.53 ? 72  LYS A CB  1 
ATOM   576  C  CG  . LYS A 1 71  ? 3.062   13.023  31.572  1.00 25.05 ? 72  LYS A CG  1 
ATOM   577  C  CD  . LYS A 1 71  ? 2.782   14.449  31.153  1.00 31.36 ? 72  LYS A CD  1 
ATOM   578  C  CE  . LYS A 1 71  ? 4.036   15.091  30.588  1.00 38.41 ? 72  LYS A CE  1 
ATOM   579  N  NZ  . LYS A 1 71  ? 3.759   16.468  30.084  1.00 38.36 ? 72  LYS A NZ  1 
ATOM   580  N  N   . LEU A 1 72  ? -0.335  10.245  32.842  1.00 20.63 ? 73  LEU A N   1 
ATOM   581  C  CA  . LEU A 1 72  ? -1.508  9.951   33.663  1.00 25.84 ? 73  LEU A CA  1 
ATOM   582  C  C   . LEU A 1 72  ? -1.317  8.695   34.496  1.00 26.46 ? 73  LEU A C   1 
ATOM   583  O  O   . LEU A 1 72  ? -1.778  8.636   35.648  1.00 29.96 ? 73  LEU A O   1 
ATOM   584  C  CB  . LEU A 1 72  ? -2.750  9.794   32.786  1.00 24.18 ? 73  LEU A CB  1 
ATOM   585  C  CG  . LEU A 1 72  ? -3.455  11.071  32.350  1.00 30.92 ? 73  LEU A CG  1 
ATOM   586  C  CD1 . LEU A 1 72  ? -4.307  10.832  31.109  1.00 34.81 ? 73  LEU A CD1 1 
ATOM   587  C  CD2 . LEU A 1 72  ? -4.306  11.591  33.505  1.00 35.51 ? 73  LEU A CD2 1 
ATOM   588  N  N   . VAL A 1 73  ? -0.690  7.662   33.928  1.00 23.01 ? 74  VAL A N   1 
ATOM   589  C  CA  . VAL A 1 73  ? -0.591  6.346   34.563  1.00 23.63 ? 74  VAL A CA  1 
ATOM   590  C  C   . VAL A 1 73  ? 0.719   6.216   35.334  1.00 29.93 ? 74  VAL A C   1 
ATOM   591  O  O   . VAL A 1 73  ? 1.075   5.124   35.798  1.00 35.42 ? 74  VAL A O   1 
ATOM   592  C  CB  . VAL A 1 73  ? -0.717  5.200   33.536  1.00 23.28 ? 74  VAL A CB  1 
ATOM   593  C  CG1 . VAL A 1 73  ? -2.077  5.244   32.833  1.00 26.89 ? 74  VAL A CG1 1 
ATOM   594  C  CG2 . VAL A 1 73  ? 0.452   5.201   32.538  1.00 25.29 ? 74  VAL A CG2 1 
ATOM   595  N  N   . GLY A 1 74  ? 1.440   7.321   35.475  1.00 24.54 ? 75  GLY A N   1 
ATOM   596  C  CA  . GLY A 1 74  ? 2.675   7.329   36.250  1.00 31.96 ? 75  GLY A CA  1 
ATOM   597  C  C   . GLY A 1 74  ? 3.829   6.568   35.631  1.00 37.45 ? 75  GLY A C   1 
ATOM   598  O  O   . GLY A 1 74  ? 4.627   5.951   36.352  1.00 36.27 ? 75  GLY A O   1 
ATOM   599  N  N   . LEU A 1 75  ? 3.946   6.606   34.314  1.00 25.30 ? 76  LEU A N   1 
ATOM   600  C  CA  . LEU A 1 75  ? 5.050   5.990   33.589  1.00 24.56 ? 76  LEU A CA  1 
ATOM   601  C  C   . LEU A 1 75  ? 5.860   7.063   32.857  1.00 24.31 ? 76  LEU A C   1 
ATOM   602  O  O   . LEU A 1 75  ? 6.381   6.831   31.764  1.00 22.91 ? 76  LEU A O   1 
ATOM   603  C  CB  . LEU A 1 75  ? 4.533   4.921   32.621  1.00 23.54 ? 76  LEU A CB  1 
ATOM   604  C  CG  . LEU A 1 75  ? 3.880   3.692   33.256  1.00 26.59 ? 76  LEU A CG  1 
ATOM   605  C  CD1 . LEU A 1 75  ? 3.360   2.740   32.201  1.00 29.27 ? 76  LEU A CD1 1 
ATOM   606  C  CD2 . LEU A 1 75  ? 4.914   3.005   34.128  1.00 31.91 ? 76  LEU A CD2 1 
ATOM   607  N  N   . GLU A 1 76  ? 6.008   8.245   33.473  1.00 22.67 ? 77  GLU A N   1 
ATOM   608  C  CA  . GLU A 1 76  ? 6.704   9.347   32.810  1.00 20.93 ? 77  GLU A CA  1 
ATOM   609  C  C   . GLU A 1 76  ? 8.151   8.995   32.477  1.00 22.18 ? 77  GLU A C   1 
ATOM   610  O  O   . GLU A 1 76  ? 8.703   9.501   31.489  1.00 22.92 ? 77  GLU A O   1 
ATOM   611  C  CB  . GLU A 1 76  ? 6.662   10.616  33.670  1.00 27.58 ? 77  GLU A CB  1 
ATOM   612  C  CG  . GLU A 1 76  ? 7.068   10.421  35.125  1.00 33.30 ? 77  GLU A CG  1 
ATOM   613  C  CD  . GLU A 1 76  ? 5.897   10.112  36.063  1.00 35.55 ? 77  GLU A CD  1 
ATOM   614  O  OE1 . GLU A 1 76  ? 4.904   9.472   35.636  1.00 33.23 ? 77  GLU A OE1 1 
ATOM   615  O  OE2 . GLU A 1 76  ? 5.972   10.532  37.243  1.00 43.36 ? 77  GLU A OE2 1 
ATOM   616  N  N   . GLU A 1 77  ? 8.767   8.105   33.255  1.00 23.16 ? 78  GLU A N   1 
ATOM   617  C  CA  . GLU A 1 77  ? 10.132  7.691   32.977  1.00 23.22 ? 78  GLU A CA  1 
ATOM   618  C  C   . GLU A 1 77  ? 10.253  6.992   31.629  1.00 20.72 ? 78  GLU A C   1 
ATOM   619  O  O   . GLU A 1 77  ? 11.366  6.861   31.112  1.00 24.57 ? 78  GLU A O   1 
ATOM   620  C  CB  . GLU A 1 77  ? 10.641  6.771   34.106  1.00 28.74 ? 78  GLU A CB  1 
ATOM   621  C  CG  . GLU A 1 77  ? 9.749   5.569   34.454  1.00 34.67 ? 78  GLU A CG  1 
ATOM   622  C  CD  . GLU A 1 77  ? 8.507   5.923   35.280  1.00 35.58 ? 78  GLU A CD  1 
ATOM   623  O  OE1 . GLU A 1 77  ? 7.945   4.997   35.919  1.00 45.68 ? 78  GLU A OE1 1 
ATOM   624  O  OE2 . GLU A 1 77  ? 8.066   7.089   35.274  1.00 40.89 ? 78  GLU A OE2 1 
ATOM   625  N  N   . LEU A 1 78  ? 9.133   6.548   31.036  1.00 19.60 ? 79  LEU A N   1 
ATOM   626  C  CA  . LEU A 1 78  ? 9.192   5.867   29.746  1.00 17.89 ? 79  LEU A CA  1 
ATOM   627  C  C   . LEU A 1 78  ? 9.025   6.799   28.561  1.00 20.50 ? 79  LEU A C   1 
ATOM   628  O  O   . LEU A 1 78  ? 9.193   6.338   27.420  1.00 20.31 ? 79  LEU A O   1 
ATOM   629  C  CB  . LEU A 1 78  ? 8.106   4.786   29.641  1.00 19.64 ? 79  LEU A CB  1 
ATOM   630  C  CG  . LEU A 1 78  ? 8.048   3.777   30.787  1.00 26.37 ? 79  LEU A CG  1 
ATOM   631  C  CD1 . LEU A 1 78  ? 6.933   2.778   30.608  1.00 24.81 ? 79  LEU A CD1 1 
ATOM   632  C  CD2 . LEU A 1 78  ? 9.381   3.087   30.945  1.00 29.70 ? 79  LEU A CD2 1 
ATOM   633  N  N   . ILE A 1 79  ? 8.734   8.078   28.795  1.00 18.14 ? 80  ILE A N   1 
ATOM   634  C  CA  . ILE A 1 79  ? 8.264   8.930   27.704  1.00 17.70 ? 80  ILE A CA  1 
ATOM   635  C  C   . ILE A 1 79  ? 9.280   8.975   26.563  1.00 18.57 ? 80  ILE A C   1 
ATOM   636  O  O   . ILE A 1 79  ? 8.938   8.713   25.396  1.00 19.84 ? 80  ILE A O   1 
ATOM   637  C  CB  . ILE A 1 79  ? 7.919   10.323  28.250  1.00 20.15 ? 80  ILE A CB  1 
ATOM   638  C  CG1 . ILE A 1 79  ? 6.623   10.224  29.058  1.00 16.59 ? 80  ILE A CG1 1 
ATOM   639  C  CG2 . ILE A 1 79  ? 7.786   11.323  27.116  1.00 24.47 ? 80  ILE A CG2 1 
ATOM   640  C  CD1 . ILE A 1 79  ? 6.249   11.506  29.774  1.00 23.54 ? 80  ILE A CD1 1 
ATOM   641  N  N   . GLU A 1 80  ? 10.557  9.211   26.883  1.00 21.82 ? 81  GLU A N   1 
ATOM   642  C  CA  . GLU A 1 80  ? 11.556  9.315   25.819  1.00 23.60 ? 81  GLU A CA  1 
ATOM   643  C  C   . GLU A 1 80  ? 11.649  8.023   25.011  1.00 21.08 ? 81  GLU A C   1 
ATOM   644  O  O   . GLU A 1 80  ? 11.609  8.042   23.770  1.00 21.41 ? 81  GLU A O   1 
ATOM   645  C  CB  . GLU A 1 80  ? 12.916  9.695   26.408  1.00 24.59 ? 81  GLU A CB  1 
ATOM   646  C  CG  . GLU A 1 80  ? 12.909  11.071  27.036  1.00 29.88 ? 81  GLU A CG  1 
ATOM   647  C  CD  . GLU A 1 80  ? 12.307  12.133  26.128  1.00 37.57 ? 81  GLU A CD  1 
ATOM   648  O  OE1 . GLU A 1 80  ? 12.697  12.221  24.939  1.00 45.32 ? 81  GLU A OE1 1 
ATOM   649  O  OE2 . GLU A 1 80  ? 11.432  12.885  26.605  1.00 42.52 ? 81  GLU A OE2 1 
ATOM   650  N  N   . GLU A 1 81  ? 11.711  6.879   25.694  1.00 18.99 ? 82  GLU A N   1 
ATOM   651  C  CA  . GLU A 1 81  ? 11.834  5.614   24.971  1.00 19.12 ? 82  GLU A CA  1 
ATOM   652  C  C   . GLU A 1 81  ? 10.604  5.370   24.114  1.00 17.27 ? 82  GLU A C   1 
ATOM   653  O  O   . GLU A 1 81  ? 10.719  4.914   22.971  1.00 17.92 ? 82  GLU A O   1 
ATOM   654  C  CB  . GLU A 1 81  ? 12.030  4.451   25.955  1.00 25.41 ? 82  GLU A CB  1 
ATOM   655  C  CG  . GLU A 1 81  ? 13.419  4.374   26.599  1.00 26.48 ? 82  GLU A CG  1 
ATOM   656  C  CD  . GLU A 1 81  ? 14.502  3.880   25.638  1.00 34.43 ? 82  GLU A CD  1 
ATOM   657  O  OE1 . GLU A 1 81  ? 14.155  3.304   24.586  1.00 35.84 ? 82  GLU A OE1 1 
ATOM   658  O  OE2 . GLU A 1 81  ? 15.704  4.079   25.932  1.00 36.94 ? 82  GLU A OE2 1 
ATOM   659  N  N   . VAL A 1 82  ? 9.417   5.683   24.643  1.00 16.70 ? 83  VAL A N   1 
ATOM   660  C  CA  . VAL A 1 82  ? 8.197   5.444   23.874  1.00 15.49 ? 83  VAL A CA  1 
ATOM   661  C  C   . VAL A 1 82  ? 8.153   6.366   22.672  1.00 16.47 ? 83  VAL A C   1 
ATOM   662  O  O   . VAL A 1 82  ? 7.779   5.943   21.564  1.00 16.88 ? 83  VAL A O   1 
ATOM   663  C  CB  . VAL A 1 82  ? 6.962   5.596   24.790  1.00 16.36 ? 83  VAL A CB  1 
ATOM   664  C  CG1 . VAL A 1 82  ? 5.669   5.659   23.985  1.00 19.77 ? 83  VAL A CG1 1 
ATOM   665  C  CG2 . VAL A 1 82  ? 6.907   4.425   25.775  1.00 17.78 ? 83  VAL A CG2 1 
ATOM   666  N  N   . LYS A 1 83  ? 8.566   7.622   22.855  1.00 16.60 ? 84  LYS A N   1 
ATOM   667  C  CA  . LYS A 1 83  ? 8.541   8.546   21.736  1.00 15.10 ? 84  LYS A CA  1 
ATOM   668  C  C   . LYS A 1 83  ? 9.495   8.052   20.664  1.00 19.00 ? 84  LYS A C   1 
ATOM   669  O  O   . LYS A 1 83  ? 9.154   8.051   19.469  1.00 18.18 ? 84  LYS A O   1 
ATOM   670  C  CB  . LYS A 1 83  ? 8.871   9.954   22.223  1.00 18.31 ? 84  LYS A CB  1 
ATOM   671  C  CG  . LYS A 1 83  ? 7.647   10.659  22.842  1.00 19.42 ? 84  LYS A CG  1 
ATOM   672  C  CD  . LYS A 1 83  ? 7.866   12.162  22.870  1.00 28.96 ? 84  LYS A CD  1 
ATOM   673  C  CE  . LYS A 1 83  ? 6.858   12.859  23.731  1.00 29.62 ? 84  LYS A CE  1 
ATOM   674  N  NZ  . LYS A 1 83  ? 7.318   14.244  24.071  1.00 35.69 ? 84  LYS A NZ  1 
ATOM   675  N  N   . LYS A 1 84  ? 10.639  7.488   21.085  1.00 16.90 ? 85  LYS A N   1 
ATOM   676  C  CA  . LYS A 1 84  ? 11.576  6.973   20.100  1.00 19.90 ? 85  LYS A CA  1 
ATOM   677  C  C   . LYS A 1 84  ? 10.931  5.841   19.308  1.00 19.33 ? 85  LYS A C   1 
ATOM   678  O  O   . LYS A 1 84  ? 10.961  5.839   18.069  1.00 24.52 ? 85  LYS A O   1 
ATOM   679  C  CB  . LYS A 1 84  ? 12.860  6.530   20.810  1.00 24.11 ? 85  LYS A CB  1 
ATOM   680  C  CG  . LYS A 1 84  ? 13.971  6.062   19.919  1.00 34.20 ? 85  LYS A CG  1 
ATOM   681  C  CD  . LYS A 1 84  ? 15.317  6.359   20.588  1.00 40.66 ? 85  LYS A CD  1 
ATOM   682  C  CE  . LYS A 1 84  ? 15.884  5.128   21.276  1.00 40.68 ? 85  LYS A CE  1 
ATOM   683  N  NZ  . LYS A 1 84  ? 17.341  5.271   21.570  1.00 42.86 ? 85  LYS A NZ  1 
ATOM   684  N  N   . GLU A 1 85  ? 10.231  4.938   20.001  1.00 17.72 ? 86  GLU A N   1 
ATOM   685  C  CA  . GLU A 1 85  ? 9.637   3.802   19.312  1.00 17.64 ? 86  GLU A CA  1 
ATOM   686  C  C   . GLU A 1 85  ? 8.600   4.285   18.317  1.00 17.08 ? 86  GLU A C   1 
ATOM   687  O  O   . GLU A 1 85  ? 8.538   3.795   17.184  1.00 18.89 ? 86  GLU A O   1 
ATOM   688  C  CB  . GLU A 1 85  ? 8.987   2.845   20.313  1.00 21.84 ? 86  GLU A CB  1 
ATOM   689  C  CG  . GLU A 1 85  ? 8.990   1.366   19.935  1.00 35.82 ? 86  GLU A CG  1 
ATOM   690  C  CD  . GLU A 1 85  ? 10.388  0.733   19.783  1.00 36.02 ? 86  GLU A CD  1 
ATOM   691  O  OE1 . GLU A 1 85  ? 11.411  1.404   20.058  1.00 39.20 ? 86  GLU A OE1 1 
ATOM   692  O  OE2 . GLU A 1 85  ? 10.451  -0.450  19.389  1.00 47.30 ? 86  GLU A OE2 1 
ATOM   693  N  N   . ILE A 1 86  ? 7.797   5.272   18.714  1.00 14.81 ? 87  ILE A N   1 
ATOM   694  C  CA  . ILE A 1 86  ? 6.742   5.730   17.823  1.00 14.26 ? 87  ILE A CA  1 
ATOM   695  C  C   . ILE A 1 86  ? 7.368   6.383   16.610  1.00 18.59 ? 87  ILE A C   1 
ATOM   696  O  O   . ILE A 1 86  ? 7.001   6.072   15.469  1.00 18.35 ? 87  ILE A O   1 
ATOM   697  C  CB  . ILE A 1 86  ? 5.767   6.649   18.571  1.00 17.18 ? 87  ILE A CB  1 
ATOM   698  C  CG1 . ILE A 1 86  ? 4.993   5.811   19.577  1.00 16.80 ? 87  ILE A CG1 1 
ATOM   699  C  CG2 . ILE A 1 86  ? 4.767   7.314   17.604  1.00 17.45 ? 87  ILE A CG2 1 
ATOM   700  C  CD1 . ILE A 1 86  ? 4.127   6.659   20.505  1.00 14.99 ? 87  ILE A CD1 1 
ATOM   701  N  N   . LYS A 1 87  ? 8.401   7.202   16.836  1.00 17.47 ? 88  LYS A N   1 
ATOM   702  C  CA  . LYS A 1 87  ? 9.067   7.826   15.707  1.00 16.26 ? 88  LYS A CA  1 
ATOM   703  C  C   . LYS A 1 87  ? 9.658   6.758   14.810  1.00 18.01 ? 88  LYS A C   1 
ATOM   704  O  O   . LYS A 1 87  ? 9.475   6.802   13.583  1.00 24.84 ? 88  LYS A O   1 
ATOM   705  C  CB  . LYS A 1 87  ? 10.122  8.809   16.195  1.00 18.80 ? 88  LYS A CB  1 
ATOM   706  C  CG  . LYS A 1 87  ? 9.527   10.054  16.780  1.00 23.85 ? 88  LYS A CG  1 
ATOM   707  C  CD  . LYS A 1 87  ? 10.568  10.868  17.553  1.00 33.85 ? 88  LYS A CD  1 
ATOM   708  C  CE  . LYS A 1 87  ? 9.895   11.839  18.512  1.00 35.39 ? 88  LYS A CE  1 
ATOM   709  N  NZ  . LYS A 1 87  ? 10.366  13.238  18.335  1.00 38.15 ? 88  LYS A NZ  1 
ATOM   710  N  N   . GLU A 1 88  ? 10.270  5.723   15.414  1.00 18.68 ? 89  GLU A N   1 
ATOM   711  C  CA  . GLU A 1 88  ? 10.890  4.690   14.594  1.00 21.05 ? 89  GLU A CA  1 
ATOM   712  C  C   . GLU A 1 88  ? 9.845   4.049   13.697  1.00 23.28 ? 89  GLU A C   1 
ATOM   713  O  O   . GLU A 1 88  ? 10.060  3.908   12.484  1.00 24.09 ? 89  GLU A O   1 
ATOM   714  C  CB  . GLU A 1 88  ? 11.586  3.642   15.462  1.00 24.96 ? 89  GLU A CB  1 
ATOM   715  C  CG  . GLU A 1 88  ? 12.977  4.039   15.937  1.00 31.36 ? 89  GLU A CG  1 
ATOM   716  C  CD  . GLU A 1 88  ? 13.557  3.057   16.946  1.00 37.49 ? 89  GLU A CD  1 
ATOM   717  O  OE1 . GLU A 1 88  ? 13.180  1.865   16.907  1.00 35.28 ? 89  GLU A OE1 1 
ATOM   718  O  OE2 . GLU A 1 88  ? 14.382  3.478   17.786  1.00 45.73 ? 89  GLU A OE2 1 
ATOM   719  N  N   . LEU A 1 89  ? 8.668   3.761   14.258  1.00 18.38 ? 90  LEU A N   1 
ATOM   720  C  CA  . LEU A 1 89  ? 7.618   3.110   13.495  1.00 13.86 ? 90  LEU A CA  1 
ATOM   721  C  C   . LEU A 1 89  ? 7.193   3.977   12.324  1.00 18.90 ? 90  LEU A C   1 
ATOM   722  O  O   . LEU A 1 89  ? 7.093   3.499   11.181  1.00 21.24 ? 90  LEU A O   1 
ATOM   723  C  CB  . LEU A 1 89  ? 6.421   2.829   14.407  1.00 17.15 ? 90  LEU A CB  1 
ATOM   724  C  CG  . LEU A 1 89  ? 5.175   2.336   13.653  1.00 22.18 ? 90  LEU A CG  1 
ATOM   725  C  CD1 . LEU A 1 89  ? 5.453   1.045   12.908  1.00 20.74 ? 90  LEU A CD1 1 
ATOM   726  C  CD2 . LEU A 1 89  ? 4.010   2.146   14.628  1.00 22.40 ? 90  LEU A CD2 1 
ATOM   727  N  N   . PHE A 1 90  ? 6.964   5.259   12.582  1.00 18.19 ? 91  PHE A N   1 
ATOM   728  C  CA  . PHE A 1 90  ? 6.483   6.115   11.510  1.00 20.15 ? 91  PHE A CA  1 
ATOM   729  C  C   . PHE A 1 90  ? 7.551   6.239   10.440  1.00 20.84 ? 91  PHE A C   1 
ATOM   730  O  O   . PHE A 1 90  ? 7.251   6.095   9.240   1.00 19.61 ? 91  PHE A O   1 
ATOM   731  C  CB  . PHE A 1 90  ? 6.065   7.473   12.069  1.00 18.18 ? 91  PHE A CB  1 
ATOM   732  C  CG  . PHE A 1 90  ? 4.632   7.528   12.532  1.00 19.01 ? 91  PHE A CG  1 
ATOM   733  C  CD1 . PHE A 1 90  ? 4.217   6.806   13.646  1.00 20.06 ? 91  PHE A CD1 1 
ATOM   734  C  CD2 . PHE A 1 90  ? 3.717   8.360   11.912  1.00 24.27 ? 91  PHE A CD2 1 
ATOM   735  C  CE1 . PHE A 1 90  ? 2.910   6.874   14.106  1.00 24.21 ? 91  PHE A CE1 1 
ATOM   736  C  CE2 . PHE A 1 90  ? 2.422   8.431   12.350  1.00 22.24 ? 91  PHE A CE2 1 
ATOM   737  C  CZ  . PHE A 1 90  ? 2.005   7.695   13.451  1.00 21.54 ? 91  PHE A CZ  1 
ATOM   738  N  N   . ASP A 1 91  ? 8.817   6.350   10.862  1.00 19.02 ? 92  ASP A N   1 
ATOM   739  C  CA  . ASP A 1 91  ? 9.891   6.398   9.874   1.00 23.10 ? 92  ASP A CA  1 
ATOM   740  C  C   . ASP A 1 91  ? 9.885   5.127   9.040   1.00 22.78 ? 92  ASP A C   1 
ATOM   741  O  O   . ASP A 1 91  ? 9.937   5.179   7.797   1.00 27.39 ? 92  ASP A O   1 
ATOM   742  C  CB  . ASP A 1 91  ? 11.235  6.578   10.560  1.00 23.86 ? 92  ASP A CB  1 
ATOM   743  C  CG  . ASP A 1 91  ? 11.528  8.029   10.899  1.00 29.82 ? 92  ASP A CG  1 
ATOM   744  O  OD1 . ASP A 1 91  ? 10.847  8.924   10.362  1.00 35.00 ? 92  ASP A OD1 1 
ATOM   745  O  OD2 . ASP A 1 91  ? 12.441  8.263   11.722  1.00 41.58 ? 92  ASP A OD2 1 
ATOM   746  N  N   . GLU A 1 92  ? 9.734   3.968   9.698   1.00 19.96 ? 93  GLU A N   1 
ATOM   747  C  CA  . GLU A 1 92  ? 9.829   2.718   8.952   1.00 21.73 ? 93  GLU A CA  1 
ATOM   748  C  C   . GLU A 1 92  ? 8.661   2.569   7.993   1.00 22.49 ? 93  GLU A C   1 
ATOM   749  O  O   . GLU A 1 92  ? 8.851   2.110   6.852   1.00 22.48 ? 93  GLU A O   1 
ATOM   750  C  CB  . GLU A 1 92  ? 9.917   1.515   9.886   1.00 22.90 ? 93  GLU A CB  1 
ATOM   751  C  CG  . GLU A 1 92  ? 10.121  0.186   9.133   1.00 25.20 ? 93  GLU A CG  1 
ATOM   752  C  CD  . GLU A 1 92  ? 11.456  0.088   8.378   1.00 35.49 ? 93  GLU A CD  1 
ATOM   753  O  OE1 . GLU A 1 92  ? 11.571  -0.793  7.494   1.00 38.64 ? 93  GLU A OE1 1 
ATOM   754  O  OE2 . GLU A 1 92  ? 12.388  0.863   8.678   1.00 40.99 ? 93  GLU A OE2 1 
ATOM   755  N  N   . LEU A 1 93  ? 7.466   3.010   8.404   1.00 19.61 ? 94  LEU A N   1 
ATOM   756  C  CA  . LEU A 1 93  ? 6.325   2.932   7.498   1.00 16.65 ? 94  LEU A CA  1 
ATOM   757  C  C   . LEU A 1 93  ? 6.628   3.728   6.245   1.00 23.69 ? 94  LEU A C   1 
ATOM   758  O  O   . LEU A 1 93  ? 6.488   3.218   5.121   1.00 21.74 ? 94  LEU A O   1 
ATOM   759  C  CB  . LEU A 1 93  ? 5.058   3.443   8.179   1.00 19.13 ? 94  LEU A CB  1 
ATOM   760  C  CG  . LEU A 1 93  ? 4.597   2.554   9.340   1.00 15.61 ? 94  LEU A CG  1 
ATOM   761  C  CD1 . LEU A 1 93  ? 3.409   3.239   10.028  1.00 14.68 ? 94  LEU A CD1 1 
ATOM   762  C  CD2 . LEU A 1 93  ? 4.243   1.158   8.885   1.00 20.39 ? 94  LEU A CD2 1 
ATOM   763  N  N   . LYS A 1 94  ? 7.148   4.947   6.431   1.00 18.95 ? 95  LYS A N   1 
ATOM   764  C  CA  . LYS A 1 94  ? 7.442   5.782   5.272   1.00 20.69 ? 95  LYS A CA  1 
ATOM   765  C  C   . LYS A 1 94  ? 8.503   5.112   4.413   1.00 22.17 ? 95  LYS A C   1 
ATOM   766  O  O   . LYS A 1 94  ? 8.403   5.110   3.174   1.00 26.85 ? 95  LYS A O   1 
ATOM   767  C  CB  . LYS A 1 94  ? 7.878   7.177   5.709   1.00 22.98 ? 95  LYS A CB  1 
ATOM   768  C  CG  . LYS A 1 94  ? 6.716   8.052   6.159   1.00 22.92 ? 95  LYS A CG  1 
ATOM   769  C  CD  . LYS A 1 94  ? 7.081   8.981   7.293   1.00 31.38 ? 95  LYS A CD  1 
ATOM   770  C  CE  . LYS A 1 94  ? 7.758   10.224  6.771   1.00 38.81 ? 95  LYS A CE  1 
ATOM   771  N  NZ  . LYS A 1 94  ? 8.190   11.117  7.879   1.00 42.50 ? 95  LYS A NZ  1 
ATOM   772  N  N   . LYS A 1 95  ? 9.499   4.491   5.054   1.00 22.11 ? 96  LYS A N   1 
ATOM   773  C  CA  . LYS A 1 95  ? 10.541  3.819   4.295   1.00 24.70 ? 96  LYS A CA  1 
ATOM   774  C  C   . LYS A 1 95  ? 9.951   2.707   3.446   1.00 24.22 ? 96  LYS A C   1 
ATOM   775  O  O   . LYS A 1 95  ? 10.253  2.600   2.248   1.00 26.15 ? 96  LYS A O   1 
ATOM   776  C  CB  . LYS A 1 95  ? 11.602  3.238   5.219   1.00 29.07 ? 96  LYS A CB  1 
ATOM   777  C  CG  . LYS A 1 95  ? 12.721  2.604   4.421   1.00 36.54 ? 96  LYS A CG  1 
ATOM   778  C  CD  . LYS A 1 95  ? 13.650  1.797   5.294   1.00 43.74 ? 96  LYS A CD  1 
ATOM   779  C  CE  . LYS A 1 95  ? 14.955  2.496   5.472   1.00 45.59 ? 96  LYS A CE  1 
ATOM   780  N  NZ  . LYS A 1 95  ? 15.627  2.790   4.172   1.00 52.80 ? 96  LYS A NZ  1 
ATOM   781  N  N   . MET A 1 96  ? 9.090   1.874   4.048   1.00 21.32 ? 97  MET A N   1 
ATOM   782  C  CA  . MET A 1 96  ? 8.585   0.777   3.249   1.00 20.52 ? 97  MET A CA  1 
ATOM   783  C  C   . MET A 1 96  ? 7.706   1.279   2.136   1.00 25.42 ? 97  MET A C   1 
ATOM   784  O  O   . MET A 1 96  ? 7.668   0.649   1.070   1.00 24.16 ? 97  MET A O   1 
ATOM   785  C  CB  . MET A 1 96  ? 7.881   -0.313  4.062   1.00 25.87 ? 97  MET A CB  1 
ATOM   786  C  CG  . MET A 1 96  ? 8.468   -0.732  5.384   1.00 20.26 ? 97  MET A CG  1 
ATOM   787  S  SD  . MET A 1 96  ? 7.316   -1.584  6.513   1.00 20.70 ? 97  MET A SD  1 
ATOM   788  C  CE  . MET A 1 96  ? 6.851   -3.004  5.544   1.00 25.07 ? 97  MET A CE  1 
ATOM   789  N  N   . ILE A 1 97  ? 7.067   2.433   2.323   1.00 23.22 ? 98  ILE A N   1 
ATOM   790  C  CA  . ILE A 1 97  ? 6.289   2.980   1.222   1.00 22.79 ? 98  ILE A CA  1 
ATOM   791  C  C   . ILE A 1 97  ? 7.226   3.434   0.123   1.00 24.19 ? 98  ILE A C   1 
ATOM   792  O  O   . ILE A 1 97  ? 7.010   3.116   -1.059  1.00 27.61 ? 98  ILE A O   1 
ATOM   793  C  CB  . ILE A 1 97  ? 5.346   4.108   1.688   1.00 24.01 ? 98  ILE A CB  1 
ATOM   794  C  CG1 . ILE A 1 97  ? 4.226   3.508   2.535   1.00 27.56 ? 98  ILE A CG1 1 
ATOM   795  C  CG2 . ILE A 1 97  ? 4.774   4.893   0.489   1.00 29.72 ? 98  ILE A CG2 1 
ATOM   796  C  CD1 . ILE A 1 97  ? 3.376   4.514   3.240   1.00 30.68 ? 98  ILE A CD1 1 
ATOM   797  N  N   . LYS A 1 98  ? 8.327   4.096   0.496   1.00 26.12 ? 99  LYS A N   1 
ATOM   798  C  CA  . LYS A 1 98  ? 9.235   4.627   -0.527  1.00 24.13 ? 99  LYS A CA  1 
ATOM   799  C  C   . LYS A 1 98  ? 9.914   3.499   -1.292  1.00 29.79 ? 99  LYS A C   1 
ATOM   800  O  O   . LYS A 1 98  ? 10.157  3.621   -2.503  1.00 31.66 ? 99  LYS A O   1 
ATOM   801  C  CB  . LYS A 1 98  ? 10.274  5.546   0.124   1.00 34.25 ? 99  LYS A CB  1 
ATOM   802  C  CG  . LYS A 1 98  ? 11.423  5.978   -0.801  1.00 32.04 ? 99  LYS A CG  1 
ATOM   803  N  N   . GLU A 1 99  ? 10.230  2.396   -0.608  1.00 25.83 ? 100 GLU A N   1 
ATOM   804  C  CA  . GLU A 1 99  ? 10.896  1.260   -1.237  1.00 30.03 ? 100 GLU A CA  1 
ATOM   805  C  C   . GLU A 1 99  ? 9.929   0.309   -1.941  1.00 24.59 ? 100 GLU A C   1 
ATOM   806  O  O   . GLU A 1 99  ? 10.369  -0.730  -2.453  1.00 30.01 ? 100 GLU A O   1 
ATOM   807  C  CB  . GLU A 1 99  ? 11.717  0.500   -0.198  1.00 32.43 ? 100 GLU A CB  1 
ATOM   808  C  CG  . GLU A 1 99  ? 12.681  1.389   0.590   1.00 38.37 ? 100 GLU A CG  1 
ATOM   809  C  CD  . GLU A 1 99  ? 14.055  0.777   0.768   1.00 47.08 ? 100 GLU A CD  1 
ATOM   810  O  OE1 . GLU A 1 99  ? 14.261  0.040   1.756   1.00 49.79 ? 100 GLU A OE1 1 
ATOM   811  O  OE2 . GLU A 1 99  ? 14.934  1.032   -0.086  1.00 53.50 ? 100 GLU A OE2 1 
ATOM   812  N  N   . GLY A 1 100 ? 8.639   0.633   -2.000  1.00 23.78 ? 101 GLY A N   1 
ATOM   813  C  CA  . GLY A 1 100 ? 7.709   -0.173  -2.768  1.00 23.59 ? 101 GLY A CA  1 
ATOM   814  C  C   . GLY A 1 100 ? 7.251   -1.447  -2.101  1.00 29.15 ? 101 GLY A C   1 
ATOM   815  O  O   . GLY A 1 100 ? 6.894   -2.410  -2.789  1.00 31.10 ? 101 GLY A O   1 
ATOM   816  N  N   . GLU A 1 101 ? 7.242   -1.492  -0.774  1.00 22.34 ? 102 GLU A N   1 
ATOM   817  C  CA  . GLU A 1 101 ? 6.691   -2.666  -0.111  1.00 27.63 ? 102 GLU A CA  1 
ATOM   818  C  C   . GLU A 1 101 ? 5.187   -2.753  -0.344  1.00 22.58 ? 102 GLU A C   1 
ATOM   819  O  O   . GLU A 1 101 ? 4.517   -1.748  -0.580  1.00 23.66 ? 102 GLU A O   1 
ATOM   820  C  CB  . GLU A 1 101 ? 7.004   -2.608  1.380   1.00 26.29 ? 102 GLU A CB  1 
ATOM   821  C  CG  . GLU A 1 101 ? 8.455   -2.933  1.728   1.00 29.55 ? 102 GLU A CG  1 
ATOM   822  C  CD  . GLU A 1 101 ? 8.838   -4.399  1.530   1.00 38.83 ? 102 GLU A CD  1 
ATOM   823  O  OE1 . GLU A 1 101 ? 8.058   -5.186  0.951   1.00 44.79 ? 102 GLU A OE1 1 
ATOM   824  O  OE2 . GLU A 1 101 ? 9.940   -4.773  1.979   1.00 52.19 ? 102 GLU A OE2 1 
ATOM   825  N  N   . SER A 1 102 ? 4.653   -3.974  -0.316  1.00 23.11 ? 103 SER A N   1 
ATOM   826  C  CA  . SER A 1 102 ? 3.226   -4.124  -0.544  1.00 18.97 ? 103 SER A CA  1 
ATOM   827  C  C   . SER A 1 102 ? 2.446   -3.486  0.602   1.00 24.89 ? 103 SER A C   1 
ATOM   828  O  O   . SER A 1 102 ? 2.903   -3.467  1.741   1.00 26.49 ? 103 SER A O   1 
ATOM   829  C  CB  . SER A 1 102 ? 2.853   -5.598  -0.672  1.00 28.15 ? 103 SER A CB  1 
ATOM   830  O  OG  . SER A 1 102 ? 3.028   -6.307  0.549   1.00 27.15 ? 103 SER A OG  1 
ATOM   831  N  N   . LYS A 1 103 ? 1.272   -2.938  0.278   1.00 23.36 ? 104 LYS A N   1 
ATOM   832  C  CA  . LYS A 1 103 ? 0.441   -2.318  1.304   1.00 25.80 ? 104 LYS A CA  1 
ATOM   833  C  C   . LYS A 1 103 ? 0.018   -3.336  2.354   1.00 26.68 ? 104 LYS A C   1 
ATOM   834  O  O   . LYS A 1 103 ? -0.064  -2.999  3.538   1.00 21.61 ? 104 LYS A O   1 
ATOM   835  C  CB  . LYS A 1 103 ? -0.774  -1.644  0.655   1.00 30.07 ? 104 LYS A CB  1 
ATOM   836  C  CG  . LYS A 1 103 ? -1.832  -1.193  1.631   1.00 35.44 ? 104 LYS A CG  1 
ATOM   837  C  CD  . LYS A 1 103 ? -2.462  0.148   1.252   1.00 44.35 ? 104 LYS A CD  1 
ATOM   838  C  CE  . LYS A 1 103 ? -1.406  1.160   0.830   1.00 42.18 ? 104 LYS A CE  1 
ATOM   839  N  NZ  . LYS A 1 103 ? -1.952  2.547   0.767   1.00 40.74 ? 104 LYS A NZ  1 
ATOM   840  N  N   . GLU A 1 104 ? -0.221  -4.582  1.942   1.00 25.75 ? 105 GLU A N   1 
ATOM   841  C  CA  . GLU A 1 104 ? -0.491  -5.667  2.889   1.00 22.64 ? 105 GLU A CA  1 
ATOM   842  C  C   . GLU A 1 104 ? 0.621   -5.789  3.928   1.00 23.37 ? 105 GLU A C   1 
ATOM   843  O  O   . GLU A 1 104 ? 0.362   -5.861  5.143   1.00 20.24 ? 105 GLU A O   1 
ATOM   844  C  CB  . GLU A 1 104 ? -0.652  -6.975  2.107   1.00 26.77 ? 105 GLU A CB  1 
ATOM   845  C  CG  . GLU A 1 104 ? -1.932  -7.067  1.297   1.00 28.47 ? 105 GLU A CG  1 
ATOM   846  C  CD  . GLU A 1 104 ? -1.867  -6.375  -0.065  1.00 37.60 ? 105 GLU A CD  1 
ATOM   847  O  OE1 . GLU A 1 104 ? -0.780  -5.909  -0.493  1.00 28.13 ? 105 GLU A OE1 1 
ATOM   848  O  OE2 . GLU A 1 104 ? -2.920  -6.334  -0.731  1.00 42.84 ? 105 GLU A OE2 1 
ATOM   849  N  N   . LYS A 1 105 ? 1.867   -5.795  3.465   1.00 21.74 ? 106 LYS A N   1 
ATOM   850  C  CA  . LYS A 1 105 ? 3.021   -5.910  4.352   1.00 21.62 ? 106 LYS A CA  1 
ATOM   851  C  C   . LYS A 1 105 ? 3.106   -4.710  5.291   1.00 20.91 ? 106 LYS A C   1 
ATOM   852  O  O   . LYS A 1 105 ? 3.379   -4.857  6.491   1.00 21.25 ? 106 LYS A O   1 
ATOM   853  C  CB  . LYS A 1 105 ? 4.288   -5.982  3.501   1.00 26.91 ? 106 LYS A CB  1 
ATOM   854  C  CG  . LYS A 1 105 ? 4.799   -7.361  3.115   1.00 34.90 ? 106 LYS A CG  1 
ATOM   855  C  CD  . LYS A 1 105 ? 6.290   -7.245  2.781   1.00 37.74 ? 106 LYS A CD  1 
ATOM   856  C  CE  . LYS A 1 105 ? 6.921   -8.573  2.417   1.00 45.42 ? 106 LYS A CE  1 
ATOM   857  N  NZ  . LYS A 1 105 ? 6.570   -8.992  1.031   1.00 48.77 ? 106 LYS A NZ  1 
ATOM   858  N  N   . ILE A 1 106 ? 2.895   -3.513  4.749   1.00 19.02 ? 107 ILE A N   1 
ATOM   859  C  CA  . ILE A 1 106 ? 2.982   -2.301  5.553   1.00 17.62 ? 107 ILE A CA  1 
ATOM   860  C  C   . ILE A 1 106 ? 1.922   -2.314  6.640   1.00 22.36 ? 107 ILE A C   1 
ATOM   861  O  O   . ILE A 1 106 ? 2.206   -2.001  7.797   1.00 18.33 ? 107 ILE A O   1 
ATOM   862  C  CB  . ILE A 1 106 ? 2.875   -1.074  4.636   1.00 18.68 ? 107 ILE A CB  1 
ATOM   863  C  CG1 . ILE A 1 106 ? 4.083   -1.104  3.694   1.00 20.81 ? 107 ILE A CG1 1 
ATOM   864  C  CG2 . ILE A 1 106 ? 2.839   0.221   5.445   1.00 20.05 ? 107 ILE A CG2 1 
ATOM   865  C  CD1 . ILE A 1 106 ? 3.994   -0.133  2.550   1.00 24.54 ? 107 ILE A CD1 1 
ATOM   866  N  N   . ILE A 1 107 ? 0.693   -2.694  6.291   1.00 19.55 ? 108 ILE A N   1 
ATOM   867  C  CA  . ILE A 1 107 ? -0.389  -2.705  7.274   1.00 18.24 ? 108 ILE A CA  1 
ATOM   868  C  C   . ILE A 1 107 ? -0.125  -3.731  8.373   1.00 19.60 ? 108 ILE A C   1 
ATOM   869  O  O   . ILE A 1 107 ? -0.284  -3.434  9.570   1.00 15.64 ? 108 ILE A O   1 
ATOM   870  C  CB  . ILE A 1 107 ? -1.732  -2.947  6.566   1.00 18.52 ? 108 ILE A CB  1 
ATOM   871  C  CG1 . ILE A 1 107 ? -2.035  -1.751  5.652   1.00 20.98 ? 108 ILE A CG1 1 
ATOM   872  C  CG2 . ILE A 1 107 ? -2.840  -3.227  7.584   1.00 23.44 ? 108 ILE A CG2 1 
ATOM   873  C  CD1 . ILE A 1 107 ? -3.198  -1.974  4.694   1.00 27.27 ? 108 ILE A CD1 1 
ATOM   874  N  N   . ILE A 1 108 ? 0.275   -4.953  7.997   1.00 17.93 ? 109 ILE A N   1 
ATOM   875  C  CA  . ILE A 1 108 ? 0.588   -5.969  9.014   1.00 14.09 ? 109 ILE A CA  1 
ATOM   876  C  C   . ILE A 1 108 ? 1.761   -5.527  9.886   1.00 18.73 ? 109 ILE A C   1 
ATOM   877  O  O   . ILE A 1 108 ? 1.724   -5.670  11.114  1.00 19.41 ? 109 ILE A O   1 
ATOM   878  C  CB  . ILE A 1 108 ? 0.872   -7.328  8.338   1.00 21.81 ? 109 ILE A CB  1 
ATOM   879  C  CG1 . ILE A 1 108 ? -0.390  -7.865  7.665   1.00 22.52 ? 109 ILE A CG1 1 
ATOM   880  C  CG2 . ILE A 1 108 ? 1.457   -8.343  9.333   1.00 21.59 ? 109 ILE A CG2 1 
ATOM   881  C  CD1 . ILE A 1 108 ? -1.660  -7.741  8.479   1.00 26.61 ? 109 ILE A CD1 1 
ATOM   882  N  N   . TYR A 1 109 ? 2.818   -4.994  9.276   1.00 18.04 ? 110 TYR A N   1 
ATOM   883  C  CA  . TYR A 1 109 ? 3.949   -4.475  10.043  1.00 18.68 ? 110 TYR A CA  1 
ATOM   884  C  C   . TYR A 1 109 ? 3.498   -3.432  11.057  1.00 17.75 ? 110 TYR A C   1 
ATOM   885  O  O   . TYR A 1 109 ? 3.903   -3.478  12.225  1.00 17.40 ? 110 TYR A O   1 
ATOM   886  C  CB  . TYR A 1 109 ? 4.995   -3.876  9.088   1.00 19.59 ? 110 TYR A CB  1 
ATOM   887  C  CG  . TYR A 1 109 ? 6.184   -3.316  9.832   1.00 16.73 ? 110 TYR A CG  1 
ATOM   888  C  CD1 . TYR A 1 109 ? 7.215   -4.155  10.231  1.00 21.60 ? 110 TYR A CD1 1 
ATOM   889  C  CD2 . TYR A 1 109 ? 6.286   -1.971  10.110  1.00 17.64 ? 110 TYR A CD2 1 
ATOM   890  C  CE1 . TYR A 1 109 ? 8.314   -3.664  10.918  1.00 25.76 ? 110 TYR A CE1 1 
ATOM   891  C  CE2 . TYR A 1 109 ? 7.399   -1.460  10.798  1.00 23.92 ? 110 TYR A CE2 1 
ATOM   892  C  CZ  . TYR A 1 109 ? 8.400   -2.320  11.188  1.00 23.14 ? 110 TYR A CZ  1 
ATOM   893  O  OH  . TYR A 1 109 ? 9.490   -1.844  11.873  1.00 29.79 ? 110 TYR A OH  1 
ATOM   894  N  N   . ASN A 1 110 ? 2.634   -2.498  10.630  1.00 16.20 ? 111 ASN A N   1 
ATOM   895  C  CA  . ASN A 1 110 ? 2.146   -1.450  11.525  1.00 14.02 ? 111 ASN A CA  1 
ATOM   896  C  C   . ASN A 1 110 ? 1.382   -2.039  12.694  1.00 18.32 ? 111 ASN A C   1 
ATOM   897  O  O   . ASN A 1 110 ? 1.571   -1.635  13.853  1.00 18.05 ? 111 ASN A O   1 
ATOM   898  C  CB  . ASN A 1 110 ? 1.237   -0.502  10.750  1.00 14.22 ? 111 ASN A CB  1 
ATOM   899  C  CG  . ASN A 1 110 ? 0.771   0.642   11.600  1.00 14.41 ? 111 ASN A CG  1 
ATOM   900  O  OD1 . ASN A 1 110 ? 1.599   1.360   12.165  1.00 17.62 ? 111 ASN A OD1 1 
ATOM   901  N  ND2 . ASN A 1 110 ? -0.541  0.818   11.716  1.00 17.73 ? 111 ASN A ND2 1 
ATOM   902  N  N   . ILE A 1 111 ? 0.490   -2.982  12.404  1.00 17.33 ? 112 ILE A N   1 
ATOM   903  C  CA  . ILE A 1 111 ? -0.311  -3.560  13.476  1.00 17.73 ? 112 ILE A CA  1 
ATOM   904  C  C   . ILE A 1 111 ? 0.574   -4.318  14.454  1.00 18.75 ? 112 ILE A C   1 
ATOM   905  O  O   . ILE A 1 111 ? 0.452   -4.154  15.680  1.00 15.49 ? 112 ILE A O   1 
ATOM   906  C  CB  . ILE A 1 111 ? -1.407  -4.438  12.870  1.00 17.32 ? 112 ILE A CB  1 
ATOM   907  C  CG1 . ILE A 1 111 ? -2.481  -3.501  12.306  1.00 20.78 ? 112 ILE A CG1 1 
ATOM   908  C  CG2 . ILE A 1 111 ? -1.941  -5.424  13.900  1.00 18.69 ? 112 ILE A CG2 1 
ATOM   909  C  CD1 . ILE A 1 111 ? -3.469  -4.184  11.464  1.00 29.37 ? 112 ILE A CD1 1 
ATOM   910  N  N   . LEU A 1 112 ? 1.525   -5.095  13.929  1.00 17.13 ? 113 LEU A N   1 
ATOM   911  C  CA  . LEU A 1 112 ? 2.436   -5.855  14.786  1.00 15.49 ? 113 LEU A CA  1 
ATOM   912  C  C   . LEU A 1 112 ? 3.261   -4.926  15.674  1.00 15.28 ? 113 LEU A C   1 
ATOM   913  O  O   . LEU A 1 112 ? 3.414   -5.187  16.876  1.00 16.53 ? 113 LEU A O   1 
ATOM   914  C  CB  . LEU A 1 112 ? 3.347   -6.731  13.924  1.00 18.86 ? 113 LEU A CB  1 
ATOM   915  C  CG  . LEU A 1 112 ? 2.718   -7.998  13.344  1.00 18.03 ? 113 LEU A CG  1 
ATOM   916  C  CD1 . LEU A 1 112 ? 3.673   -8.632  12.297  1.00 21.81 ? 113 LEU A CD1 1 
ATOM   917  C  CD2 . LEU A 1 112 ? 2.442   -9.003  14.426  1.00 21.72 ? 113 LEU A CD2 1 
ATOM   918  N  N   . LYS A 1 113 ? 3.798   -3.842  15.107  1.00 17.65 ? 114 LYS A N   1 
ATOM   919  C  CA  . LYS A 1 113 ? 4.644   -2.932  15.889  1.00 15.95 ? 114 LYS A CA  1 
ATOM   920  C  C   . LYS A 1 113 ? 3.837   -2.187  16.956  1.00 16.30 ? 114 LYS A C   1 
ATOM   921  O  O   . LYS A 1 113 ? 4.312   -1.995  18.097  1.00 17.99 ? 114 LYS A O   1 
ATOM   922  C  CB  . LYS A 1 113 ? 5.340   -1.950  14.942  1.00 16.97 ? 114 LYS A CB  1 
ATOM   923  C  CG  . LYS A 1 113 ? 6.505   -2.576  14.218  1.00 21.68 ? 114 LYS A CG  1 
ATOM   924  C  CD  . LYS A 1 113 ? 7.575   -3.011  15.229  1.00 32.46 ? 114 LYS A CD  1 
ATOM   925  C  CE  . LYS A 1 113 ? 8.797   -3.577  14.553  1.00 37.57 ? 114 LYS A CE  1 
ATOM   926  N  NZ  . LYS A 1 113 ? 9.760   -4.048  15.569  1.00 35.48 ? 114 LYS A NZ  1 
ATOM   927  N  N   . ASN A 1 114 ? 2.601   -1.784  16.635  1.00 15.82 ? 115 ASN A N   1 
ATOM   928  C  CA  . ASN A 1 114 ? 1.761   -1.137  17.660  1.00 11.36 ? 115 ASN A CA  1 
ATOM   929  C  C   . ASN A 1 114 ? 1.477   -2.094  18.816  1.00 14.54 ? 115 ASN A C   1 
ATOM   930  O  O   . ASN A 1 114 ? 1.549   -1.704  19.991  1.00 16.89 ? 115 ASN A O   1 
ATOM   931  C  CB  . ASN A 1 114 ? 0.459   -0.671  17.012  1.00 15.66 ? 115 ASN A CB  1 
ATOM   932  C  CG  . ASN A 1 114 ? 0.559   0.723   16.412  1.00 19.46 ? 115 ASN A CG  1 
ATOM   933  O  OD1 . ASN A 1 114 ? 0.673   1.718   17.138  1.00 23.77 ? 115 ASN A OD1 1 
ATOM   934  N  ND2 . ASN A 1 114 ? 0.552   0.798   15.076  1.00 14.37 ? 115 ASN A ND2 1 
ATOM   935  N  N   . PHE A 1 115 ? 1.159   -3.356  18.502  1.00 13.73 ? 116 PHE A N   1 
ATOM   936  C  CA  . PHE A 1 115 ? 0.917   -4.346  19.551  1.00 14.71 ? 116 PHE A CA  1 
ATOM   937  C  C   . PHE A 1 115 ? 2.164   -4.604  20.381  1.00 20.29 ? 116 PHE A C   1 
ATOM   938  O  O   . PHE A 1 115 ? 2.067   -4.796  21.596  1.00 19.76 ? 116 PHE A O   1 
ATOM   939  C  CB  . PHE A 1 115 ? 0.404   -5.623  18.917  1.00 15.68 ? 116 PHE A CB  1 
ATOM   940  C  CG  . PHE A 1 115 ? -1.082  -5.685  18.771  1.00 17.71 ? 116 PHE A CG  1 
ATOM   941  C  CD1 . PHE A 1 115 ? -1.924  -5.345  19.811  1.00 21.96 ? 116 PHE A CD1 1 
ATOM   942  C  CD2 . PHE A 1 115 ? -1.643  -6.033  17.559  1.00 24.96 ? 116 PHE A CD2 1 
ATOM   943  C  CE1 . PHE A 1 115 ? -3.301  -5.411  19.669  1.00 24.02 ? 116 PHE A CE1 1 
ATOM   944  C  CE2 . PHE A 1 115 ? -3.022  -6.084  17.396  1.00 29.68 ? 116 PHE A CE2 1 
ATOM   945  C  CZ  . PHE A 1 115 ? -3.853  -5.763  18.449  1.00 28.98 ? 116 PHE A CZ  1 
ATOM   946  N  N   . GLU A 1 116 ? 3.339   -4.629  19.750  1.00 18.18 ? 117 GLU A N   1 
ATOM   947  C  CA  . GLU A 1 116 ? 4.556   -4.899  20.507  1.00 17.62 ? 117 GLU A CA  1 
ATOM   948  C  C   . GLU A 1 116 ? 4.748   -3.818  21.561  1.00 18.43 ? 117 GLU A C   1 
ATOM   949  O  O   . GLU A 1 116 ? 4.964   -4.112  22.751  1.00 20.38 ? 117 GLU A O   1 
ATOM   950  C  CB  . GLU A 1 116 ? 5.765   -4.971  19.569  1.00 22.62 ? 117 GLU A CB  1 
ATOM   951  C  CG  . GLU A 1 116 ? 7.042   -4.368  20.147  1.00 34.54 ? 117 GLU A CG  1 
ATOM   952  C  CD  . GLU A 1 116 ? 8.169   -4.206  19.135  1.00 38.91 ? 117 GLU A CD  1 
ATOM   953  O  OE1 . GLU A 1 116 ? 9.090   -3.400  19.424  1.00 42.61 ? 117 GLU A OE1 1 
ATOM   954  O  OE2 . GLU A 1 116 ? 8.138   -4.859  18.060  1.00 37.06 ? 117 GLU A OE2 1 
ATOM   955  N  N   . LEU A 1 117 ? 4.586   -2.553  21.141  1.00 17.08 ? 118 LEU A N   1 
ATOM   956  C  CA  . LEU A 1 117 ? 4.681   -1.429  22.078  1.00 14.23 ? 118 LEU A CA  1 
ATOM   957  C  C   . LEU A 1 117 ? 3.604   -1.498  23.156  1.00 16.39 ? 118 LEU A C   1 
ATOM   958  O  O   . LEU A 1 117 ? 3.906   -1.326  24.349  1.00 18.96 ? 118 LEU A O   1 
ATOM   959  C  CB  . LEU A 1 117 ? 4.605   -0.107  21.304  1.00 14.87 ? 118 LEU A CB  1 
ATOM   960  C  CG  . LEU A 1 117 ? 4.763   1.147   22.173  1.00 18.37 ? 118 LEU A CG  1 
ATOM   961  C  CD1 . LEU A 1 117 ? 6.083   1.110   22.974  1.00 21.34 ? 118 LEU A CD1 1 
ATOM   962  C  CD2 . LEU A 1 117 ? 4.718   2.416   21.351  1.00 21.22 ? 118 LEU A CD2 1 
ATOM   963  N  N   . GLU A 1 118 ? 2.354   -1.783  22.752  1.00 17.44 ? 119 GLU A N   1 
ATOM   964  C  CA  . GLU A 1 118 ? 1.215   -1.895  23.672  1.00 21.03 ? 119 GLU A CA  1 
ATOM   965  C  C   . GLU A 1 118 ? 1.442   -2.925  24.766  1.00 19.08 ? 119 GLU A C   1 
ATOM   966  O  O   . GLU A 1 118 ? 1.248   -2.634  25.966  1.00 19.33 ? 119 GLU A O   1 
ATOM   967  C  CB  . GLU A 1 118 ? -0.044  -2.274  22.881  1.00 24.28 ? 119 GLU A CB  1 
ATOM   968  C  CG  . GLU A 1 118 ? -1.322  -2.313  23.720  1.00 26.17 ? 119 GLU A CG  1 
ATOM   969  C  CD  . GLU A 1 118 ? -2.543  -2.705  22.908  1.00 27.71 ? 119 GLU A CD  1 
ATOM   970  O  OE1 . GLU A 1 118 ? -3.477  -1.897  22.818  1.00 33.45 ? 119 GLU A OE1 1 
ATOM   971  O  OE2 . GLU A 1 118 ? -2.558  -3.810  22.330  1.00 35.84 ? 119 GLU A OE2 1 
ATOM   972  N  N   . ILE A 1 119 ? 1.784   -4.148  24.367  1.00 19.54 ? 120 ILE A N   1 
ATOM   973  C  CA  . ILE A 1 119 ? 1.947   -5.233  25.324  1.00 18.87 ? 120 ILE A CA  1 
ATOM   974  C  C   . ILE A 1 119 ? 3.142   -4.956  26.226  1.00 19.63 ? 120 ILE A C   1 
ATOM   975  O  O   . ILE A 1 119 ? 3.084   -5.230  27.425  1.00 20.47 ? 120 ILE A O   1 
ATOM   976  C  CB  . ILE A 1 119 ? 2.041   -6.597  24.608  1.00 23.61 ? 120 ILE A CB  1 
ATOM   977  C  CG1 . ILE A 1 119 ? 0.644   -7.189  24.415  1.00 27.59 ? 120 ILE A CG1 1 
ATOM   978  C  CG2 . ILE A 1 119 ? 2.880   -7.606  25.403  1.00 23.24 ? 120 ILE A CG2 1 
ATOM   979  C  CD1 . ILE A 1 119 ? -0.158  -6.556  23.313  1.00 28.90 ? 120 ILE A CD1 1 
ATOM   980  N  N   . LEU A 1 120 ? 4.216   -4.356  25.686  1.00 15.90 ? 121 LEU A N   1 
ATOM   981  C  CA  . LEU A 1 120 ? 5.359   -3.997  26.527  1.00 18.05 ? 121 LEU A CA  1 
ATOM   982  C  C   . LEU A 1 120 ? 4.942   -3.017  27.618  1.00 17.65 ? 121 LEU A C   1 
ATOM   983  O  O   . LEU A 1 120 ? 5.269   -3.193  28.810  1.00 18.97 ? 121 LEU A O   1 
ATOM   984  C  CB  . LEU A 1 120 ? 6.484   -3.403  25.655  1.00 19.57 ? 121 LEU A CB  1 
ATOM   985  C  CG  . LEU A 1 120 ? 7.609   -2.661  26.393  1.00 22.64 ? 121 LEU A CG  1 
ATOM   986  C  CD1 . LEU A 1 120 ? 8.394   -3.685  27.200  1.00 22.71 ? 121 LEU A CD1 1 
ATOM   987  C  CD2 . LEU A 1 120 ? 8.583   -1.991  25.416  1.00 24.52 ? 121 LEU A CD2 1 
ATOM   988  N  N   . LEU A 1 121 ? 4.193   -1.980  27.238  1.00 16.86 ? 122 LEU A N   1 
ATOM   989  C  CA  . LEU A 1 121 ? 3.730   -1.014  28.229  1.00 14.31 ? 122 LEU A CA  1 
ATOM   990  C  C   . LEU A 1 121 ? 2.807   -1.661  29.251  1.00 17.28 ? 122 LEU A C   1 
ATOM   991  O  O   . LEU A 1 121 ? 2.894   -1.347  30.432  1.00 21.12 ? 122 LEU A O   1 
ATOM   992  C  CB  . LEU A 1 121 ? 3.030   0.155   27.545  1.00 17.09 ? 122 LEU A CB  1 
ATOM   993  C  CG  . LEU A 1 121 ? 4.011   1.016   26.757  1.00 16.09 ? 122 LEU A CG  1 
ATOM   994  C  CD1 . LEU A 1 121 ? 3.206   2.037   26.013  1.00 18.74 ? 122 LEU A CD1 1 
ATOM   995  C  CD2 . LEU A 1 121 ? 5.019   1.693   27.693  1.00 19.19 ? 122 LEU A CD2 1 
ATOM   996  N  N   . ALA A 1 122 ? 1.904   -2.540  28.797  1.00 18.02 ? 123 ALA A N   1 
ATOM   997  C  CA  . ALA A 1 122 ? 0.991   -3.216  29.717  1.00 18.32 ? 123 ALA A CA  1 
ATOM   998  C  C   . ALA A 1 122 ? 1.753   -4.070  30.719  1.00 17.14 ? 123 ALA A C   1 
ATOM   999  O  O   . ALA A 1 122 ? 1.451   -4.048  31.927  1.00 19.92 ? 123 ALA A O   1 
ATOM   1000 C  CB  . ALA A 1 122 ? 0.004   -4.066  28.919  1.00 21.68 ? 123 ALA A CB  1 
ATOM   1001 N  N   . MET A 1 123 ? 2.739   -4.825  30.239  1.00 18.08 ? 124 MET A N   1 
ATOM   1002 C  CA  . MET A 1 123 ? 3.529   -5.674  31.128  1.00 18.31 ? 124 MET A CA  1 
ATOM   1003 C  C   . MET A 1 123 ? 4.368   -4.860  32.104  1.00 24.12 ? 124 MET A C   1 
ATOM   1004 O  O   . MET A 1 123 ? 4.494   -5.246  33.281  1.00 23.96 ? 124 MET A O   1 
ATOM   1005 C  CB  . MET A 1 123 ? 4.395   -6.649  30.333  1.00 19.04 ? 124 MET A CB  1 
ATOM   1006 C  CG  . MET A 1 123 ? 3.610   -7.736  29.632  1.00 24.04 ? 124 MET A CG  1 
ATOM   1007 S  SD  . MET A 1 123 ? 4.576   -8.754  28.516  1.00 25.77 ? 124 MET A SD  1 
ATOM   1008 C  CE  . MET A 1 123 ? 4.999   -10.091 29.635  1.00 28.87 ? 124 MET A CE  1 
ATOM   1009 N  N   . ILE A 1 124 ? 4.951   -3.743  31.649  1.00 18.70 ? 125 ILE A N   1 
ATOM   1010 C  CA  . ILE A 1 124 ? 5.681   -2.864  32.558  1.00 17.81 ? 125 ILE A CA  1 
ATOM   1011 C  C   . ILE A 1 124 ? 4.743   -2.327  33.638  1.00 21.21 ? 125 ILE A C   1 
ATOM   1012 O  O   . ILE A 1 124 ? 5.070   -2.344  34.836  1.00 22.65 ? 125 ILE A O   1 
ATOM   1013 C  CB  . ILE A 1 124 ? 6.364   -1.713  31.788  1.00 18.58 ? 125 ILE A CB  1 
ATOM   1014 C  CG1 . ILE A 1 124 ? 7.584   -2.232  31.014  1.00 21.66 ? 125 ILE A CG1 1 
ATOM   1015 C  CG2 . ILE A 1 124 ? 6.838   -0.620  32.758  1.00 23.27 ? 125 ILE A CG2 1 
ATOM   1016 C  CD1 . ILE A 1 124 ? 8.000   -1.347  29.854  1.00 21.23 ? 125 ILE A CD1 1 
ATOM   1017 N  N   . GLU A 1 125 ? 3.553   -1.863  33.236  1.00 19.72 ? 126 GLU A N   1 
ATOM   1018 C  CA  . GLU A 1 125 ? 2.582   -1.323  34.189  1.00 19.89 ? 126 GLU A CA  1 
ATOM   1019 C  C   . GLU A 1 125 ? 2.136   -2.375  35.209  1.00 24.11 ? 126 GLU A C   1 
ATOM   1020 O  O   . GLU A 1 125 ? 1.935   -2.057  36.392  1.00 27.07 ? 126 GLU A O   1 
ATOM   1021 C  CB  . GLU A 1 125 ? 1.377   -0.760  33.424  1.00 25.50 ? 126 GLU A CB  1 
ATOM   1022 C  CG  . GLU A 1 125 ? 0.156   -0.485  34.303  1.00 24.22 ? 126 GLU A CG  1 
ATOM   1023 C  CD  . GLU A 1 125 ? 0.358   0.670   35.234  1.00 32.14 ? 126 GLU A CD  1 
ATOM   1024 O  OE1 . GLU A 1 125 ? 1.267   1.489   35.008  1.00 33.22 ? 126 GLU A OE1 1 
ATOM   1025 O  OE2 . GLU A 1 125 ? -0.384  0.744   36.237  1.00 29.67 ? 126 GLU A OE2 1 
ATOM   1026 N  N   . LYS A 1 126 ? 1.952   -3.623  34.775  1.00 23.44 ? 127 LYS A N   1 
ATOM   1027 C  CA  . LYS A 1 126 ? 1.627   -4.707  35.707  1.00 24.68 ? 127 LYS A CA  1 
ATOM   1028 C  C   . LYS A 1 126 ? 2.833   -5.246  36.478  1.00 31.19 ? 127 LYS A C   1 
ATOM   1029 O  O   . LYS A 1 126 ? 2.653   -6.086  37.374  1.00 32.47 ? 127 LYS A O   1 
ATOM   1030 C  CB  . LYS A 1 126 ? 0.913   -5.843  34.975  1.00 32.18 ? 127 LYS A CB  1 
ATOM   1031 C  CG  . LYS A 1 126 ? 0.112   -6.741  35.935  1.00 40.16 ? 127 LYS A CG  1 
ATOM   1032 C  CD  . LYS A 1 126 ? -1.286  -7.016  35.475  1.00 42.57 ? 127 LYS A CD  1 
ATOM   1033 C  CE  . LYS A 1 126 ? -2.216  -5.951  36.030  1.00 44.04 ? 127 LYS A CE  1 
ATOM   1034 N  NZ  . LYS A 1 126 ? -3.634  -6.407  36.111  1.00 44.97 ? 127 LYS A NZ  1 
ATOM   1035 N  N   . GLY A 1 127 ? 4.044   -4.771  36.211  1.00 24.59 ? 128 GLY A N   1 
ATOM   1036 C  CA  . GLY A 1 127 ? 5.190   -5.226  36.981  1.00 27.24 ? 128 GLY A CA  1 
ATOM   1037 C  C   . GLY A 1 127 ? 5.674   -6.622  36.666  1.00 34.29 ? 128 GLY A C   1 
ATOM   1038 O  O   . GLY A 1 127 ? 6.249   -7.281  37.544  1.00 30.79 ? 128 GLY A O   1 
ATOM   1039 N  N   . GLU A 1 128 ? 5.474   -7.091  35.434  1.00 31.20 ? 129 GLU A N   1 
ATOM   1040 C  CA  . GLU A 1 128 ? 5.999   -8.384  35.019  1.00 30.06 ? 129 GLU A CA  1 
ATOM   1041 C  C   . GLU A 1 128 ? 7.529   -8.370  35.035  1.00 30.54 ? 129 GLU A C   1 
ATOM   1042 O  O   . GLU A 1 128 ? 8.165   -7.344  34.788  1.00 33.66 ? 129 GLU A O   1 
ATOM   1043 C  CB  . GLU A 1 128 ? 5.492   -8.741  33.617  1.00 26.55 ? 129 GLU A CB  1 
ATOM   1044 C  CG  . GLU A 1 128 ? 3.978   -8.781  33.528  1.00 30.04 ? 129 GLU A CG  1 
ATOM   1045 C  CD  . GLU A 1 128 ? 3.408   -10.092 34.020  1.00 43.89 ? 129 GLU A CD  1 
ATOM   1046 O  OE1 . GLU A 1 128 ? 4.201   -11.021 34.267  1.00 45.81 ? 129 GLU A OE1 1 
ATOM   1047 O  OE2 . GLU A 1 128 ? 2.177   -10.181 34.204  1.00 47.72 ? 129 GLU A OE2 1 
ATOM   1048 N  N   . LYS A 1 129 ? 8.121   -9.529  35.316  1.00 35.31 ? 130 LYS A N   1 
ATOM   1049 C  CA  . LYS A 1 129 ? 9.574   -9.620  35.374  1.00 35.52 ? 130 LYS A CA  1 
ATOM   1050 C  C   . LYS A 1 129 ? 10.184  -9.469  33.987  1.00 35.74 ? 130 LYS A C   1 
ATOM   1051 O  O   . LYS A 1 129 ? 9.562   -9.787  32.969  1.00 31.39 ? 130 LYS A O   1 
ATOM   1052 C  CB  . LYS A 1 129 ? 10.034  -10.951 35.970  1.00 40.99 ? 130 LYS A CB  1 
ATOM   1053 C  CG  . LYS A 1 129 ? 9.404   -11.365 37.283  1.00 43.43 ? 130 LYS A CG  1 
ATOM   1054 C  CD  . LYS A 1 129 ? 8.154   -12.168 37.024  1.00 48.51 ? 130 LYS A CD  1 
ATOM   1055 C  CE  . LYS A 1 129 ? 8.473   -13.626 36.710  1.00 50.89 ? 130 LYS A CE  1 
ATOM   1056 N  NZ  . LYS A 1 129 ? 7.238   -14.403 36.367  1.00 48.95 ? 130 LYS A NZ  1 
ATOM   1057 N  N   . GLU A 1 130 ? 11.438  -9.009  33.962  1.00 33.27 ? 131 GLU A N   1 
ATOM   1058 C  CA  . GLU A 1 130 ? 12.106  -8.731  32.692  1.00 38.82 ? 131 GLU A CA  1 
ATOM   1059 C  C   . GLU A 1 130 ? 12.200  -9.970  31.811  1.00 36.62 ? 131 GLU A C   1 
ATOM   1060 O  O   . GLU A 1 130 ? 12.136  -9.866  30.582  1.00 36.48 ? 131 GLU A O   1 
ATOM   1061 C  CB  . GLU A 1 130 ? 13.499  -8.155  32.956  1.00 44.23 ? 131 GLU A CB  1 
ATOM   1062 C  CG  . GLU A 1 130 ? 13.568  -7.207  34.151  1.00 51.53 ? 131 GLU A CG  1 
ATOM   1063 C  CD  . GLU A 1 130 ? 14.368  -5.949  33.855  1.00 61.65 ? 131 GLU A CD  1 
ATOM   1064 O  OE1 . GLU A 1 130 ? 13.909  -4.845  34.231  1.00 59.44 ? 131 GLU A OE1 1 
ATOM   1065 O  OE2 . GLU A 1 130 ? 15.447  -6.062  33.228  1.00 59.31 ? 131 GLU A OE2 1 
ATOM   1066 N  N   . GLU A 1 131 ? 12.338  -11.150 32.413  1.00 38.23 ? 132 GLU A N   1 
ATOM   1067 C  CA  . GLU A 1 131 ? 12.435  -12.376 31.628  1.00 33.04 ? 132 GLU A CA  1 
ATOM   1068 C  C   . GLU A 1 131 ? 11.135  -12.672 30.878  1.00 32.17 ? 132 GLU A C   1 
ATOM   1069 O  O   . GLU A 1 131 ? 11.167  -13.082 29.711  1.00 33.05 ? 132 GLU A O   1 
ATOM   1070 C  CB  . GLU A 1 131 ? 12.841  -13.529 32.548  1.00 40.90 ? 132 GLU A CB  1 
ATOM   1071 C  CG  . GLU A 1 131 ? 11.849  -13.802 33.656  1.00 41.11 ? 132 GLU A CG  1 
ATOM   1072 C  CD  . GLU A 1 131 ? 12.383  -13.394 35.021  1.00 52.67 ? 132 GLU A CD  1 
ATOM   1073 O  OE1 . GLU A 1 131 ? 12.929  -12.263 35.129  1.00 48.58 ? 132 GLU A OE1 1 
ATOM   1074 O  OE2 . GLU A 1 131 ? 12.251  -14.188 35.982  1.00 47.33 ? 132 GLU A OE2 1 
ATOM   1075 N  N   . GLU A 1 132 ? 9.982   -12.445 31.513  1.00 31.22 ? 133 GLU A N   1 
ATOM   1076 C  CA  . GLU A 1 132 ? 8.710   -12.672 30.828  1.00 30.25 ? 133 GLU A CA  1 
ATOM   1077 C  C   . GLU A 1 132 ? 8.511   -11.669 29.697  1.00 31.69 ? 133 GLU A C   1 
ATOM   1078 O  O   . GLU A 1 132 ? 8.040   -12.025 28.602  1.00 30.00 ? 133 GLU A O   1 
ATOM   1079 C  CB  . GLU A 1 132 ? 7.558   -12.585 31.826  1.00 34.50 ? 133 GLU A CB  1 
ATOM   1080 C  CG  . GLU A 1 132 ? 7.289   -13.890 32.538  1.00 41.09 ? 133 GLU A CG  1 
ATOM   1081 C  CD  . GLU A 1 132 ? 6.761   -14.948 31.589  1.00 49.05 ? 133 GLU A CD  1 
ATOM   1082 O  OE1 . GLU A 1 132 ? 5.551   -14.919 31.262  1.00 48.33 ? 133 GLU A OE1 1 
ATOM   1083 O  OE2 . GLU A 1 132 ? 7.566   -15.805 31.163  1.00 51.98 ? 133 GLU A OE2 1 
ATOM   1084 N  N   . ILE A 1 133 ? 8.878   -10.413 29.947  1.00 30.52 ? 134 ILE A N   1 
ATOM   1085 C  CA  . ILE A 1 133 ? 8.798   -9.382  28.916  1.00 27.82 ? 134 ILE A CA  1 
ATOM   1086 C  C   . ILE A 1 133 ? 9.652   -9.774  27.722  1.00 32.24 ? 134 ILE A C   1 
ATOM   1087 O  O   . ILE A 1 133 ? 9.228   -9.661  26.561  1.00 30.36 ? 134 ILE A O   1 
ATOM   1088 C  CB  . ILE A 1 133 ? 9.221   -8.023  29.501  1.00 26.18 ? 134 ILE A CB  1 
ATOM   1089 C  CG1 . ILE A 1 133 ? 8.216   -7.588  30.568  1.00 25.07 ? 134 ILE A CG1 1 
ATOM   1090 C  CG2 . ILE A 1 133 ? 9.320   -6.967  28.398  1.00 28.72 ? 134 ILE A CG2 1 
ATOM   1091 C  CD1 . ILE A 1 133 ? 8.580   -6.335  31.284  1.00 29.98 ? 134 ILE A CD1 1 
ATOM   1092 N  N   . GLU A 1 134 ? 10.861  -10.271 27.985  1.00 28.72 ? 135 GLU A N   1 
ATOM   1093 C  CA  . GLU A 1 134 ? 11.721  -10.684 26.887  1.00 31.04 ? 135 GLU A CA  1 
ATOM   1094 C  C   . GLU A 1 134 ? 11.141  -11.878 26.144  1.00 27.42 ? 135 GLU A C   1 
ATOM   1095 O  O   . GLU A 1 134 ? 11.250  -11.966 24.914  1.00 33.44 ? 135 GLU A O   1 
ATOM   1096 C  CB  . GLU A 1 134 ? 13.111  -11.006 27.410  1.00 29.44 ? 135 GLU A CB  1 
ATOM   1097 C  CG  . GLU A 1 134 ? 14.056  -11.244 26.288  1.00 30.99 ? 135 GLU A CG  1 
ATOM   1098 C  CD  . GLU A 1 134 ? 15.282  -11.980 26.720  1.00 37.36 ? 135 GLU A CD  1 
ATOM   1099 O  OE1 . GLU A 1 134 ? 15.493  -12.141 27.940  1.00 37.75 ? 135 GLU A OE1 1 
ATOM   1100 O  OE2 . GLU A 1 134 ? 16.033  -12.382 25.821  1.00 34.98 ? 135 GLU A OE2 1 
ATOM   1101 N  N   . LYS A 1 135 ? 10.565  -12.830 26.884  1.00 26.49 ? 136 LYS A N   1 
ATOM   1102 C  CA  . LYS A 1 135 ? 9.944   -13.994 26.267  1.00 33.47 ? 136 LYS A CA  1 
ATOM   1103 C  C   . LYS A 1 135 ? 8.921   -13.548 25.230  1.00 29.90 ? 136 LYS A C   1 
ATOM   1104 O  O   . LYS A 1 135 ? 8.922   -14.015 24.079  1.00 33.96 ? 136 LYS A O   1 
ATOM   1105 C  CB  . LYS A 1 135 ? 9.280   -14.832 27.367  1.00 35.08 ? 136 LYS A CB  1 
ATOM   1106 C  CG  . LYS A 1 135 ? 8.654   -16.144 26.943  1.00 48.47 ? 136 LYS A CG  1 
ATOM   1107 C  CD  . LYS A 1 135 ? 9.653   -17.030 26.213  1.00 45.54 ? 136 LYS A CD  1 
ATOM   1108 C  CE  . LYS A 1 135 ? 9.071   -17.642 24.955  1.00 51.79 ? 136 LYS A CE  1 
ATOM   1109 N  NZ  . LYS A 1 135 ? 9.350   -16.806 23.758  1.00 43.67 ? 136 LYS A NZ  1 
ATOM   1110 N  N   . TYR A 1 136 ? 8.065   -12.597 25.618  1.00 29.22 ? 137 TYR A N   1 
ATOM   1111 C  CA  . TYR A 1 136 ? 7.018   -12.133 24.710  1.00 29.04 ? 137 TYR A CA  1 
ATOM   1112 C  C   . TYR A 1 136 ? 7.610   -11.324 23.551  1.00 28.25 ? 137 TYR A C   1 
ATOM   1113 O  O   . TYR A 1 136 ? 7.168   -11.453 22.399  1.00 29.16 ? 137 TYR A O   1 
ATOM   1114 C  CB  . TYR A 1 136 ? 5.980   -11.353 25.520  1.00 33.40 ? 137 TYR A CB  1 
ATOM   1115 C  CG  . TYR A 1 136 ? 4.979   -12.314 26.148  1.00 34.16 ? 137 TYR A CG  1 
ATOM   1116 C  CD1 . TYR A 1 136 ? 3.952   -12.864 25.403  1.00 38.07 ? 137 TYR A CD1 1 
ATOM   1117 C  CD2 . TYR A 1 136 ? 5.143   -12.763 27.451  1.00 39.81 ? 137 TYR A CD2 1 
ATOM   1118 C  CE1 . TYR A 1 136 ? 3.061   -13.782 25.954  1.00 31.86 ? 137 TYR A CE1 1 
ATOM   1119 C  CE2 . TYR A 1 136 ? 4.258   -13.682 28.017  1.00 39.85 ? 137 TYR A CE2 1 
ATOM   1120 C  CZ  . TYR A 1 136 ? 3.226   -14.191 27.261  1.00 41.81 ? 137 TYR A CZ  1 
ATOM   1121 O  OH  . TYR A 1 136 ? 2.344   -15.094 27.820  1.00 47.88 ? 137 TYR A OH  1 
ATOM   1122 N  N   . ARG A 1 137 ? 8.656   -10.536 23.818  1.00 25.30 ? 138 ARG A N   1 
ATOM   1123 C  CA  . ARG A 1 137 ? 9.255   -9.758  22.730  1.00 27.18 ? 138 ARG A CA  1 
ATOM   1124 C  C   . ARG A 1 137 ? 9.866   -10.670 21.668  1.00 26.07 ? 138 ARG A C   1 
ATOM   1125 O  O   . ARG A 1 137 ? 9.684   -10.450 20.466  1.00 29.97 ? 138 ARG A O   1 
ATOM   1126 C  CB  . ARG A 1 137 ? 10.321  -8.807  23.262  1.00 28.21 ? 138 ARG A CB  1 
ATOM   1127 C  CG  . ARG A 1 137 ? 11.311  -8.378  22.177  1.00 34.81 ? 138 ARG A CG  1 
ATOM   1128 C  CD  . ARG A 1 137 ? 12.207  -7.240  22.620  1.00 35.31 ? 138 ARG A CD  1 
ATOM   1129 N  NE  . ARG A 1 137 ? 13.221  -7.689  23.565  1.00 33.73 ? 138 ARG A NE  1 
ATOM   1130 C  CZ  . ARG A 1 137 ? 14.346  -8.295  23.209  1.00 38.69 ? 138 ARG A CZ  1 
ATOM   1131 N  NH1 . ARG A 1 137 ? 14.623  -8.550  21.940  1.00 42.86 ? 138 ARG A NH1 1 
ATOM   1132 N  NH2 . ARG A 1 137 ? 15.219  -8.653  24.149  1.00 37.48 ? 138 ARG A NH2 1 
ATOM   1133 N  N   . LYS A 1 138 ? 10.603  -11.695 22.094  1.00 28.64 ? 139 LYS A N   1 
ATOM   1134 C  CA  . LYS A 1 138 ? 11.252  -12.572 21.127  1.00 30.04 ? 139 LYS A CA  1 
ATOM   1135 C  C   . LYS A 1 138 ? 10.239  -13.436 20.393  1.00 31.32 ? 139 LYS A C   1 
ATOM   1136 O  O   . LYS A 1 138 ? 10.385  -13.671 19.181  1.00 34.25 ? 139 LYS A O   1 
ATOM   1137 C  CB  . LYS A 1 138 ? 12.326  -13.426 21.805  1.00 36.61 ? 139 LYS A CB  1 
ATOM   1138 C  CG  . LYS A 1 138 ? 13.245  -12.654 22.741  1.00 42.46 ? 139 LYS A CG  1 
ATOM   1139 C  CD  . LYS A 1 138 ? 14.439  -12.102 21.977  1.00 43.84 ? 139 LYS A CD  1 
ATOM   1140 C  CE  . LYS A 1 138 ? 15.712  -12.152 22.804  1.00 41.04 ? 139 LYS A CE  1 
ATOM   1141 N  NZ  . LYS A 1 138 ? 16.795  -12.919 22.120  1.00 48.71 ? 139 LYS A NZ  1 
ATOM   1142 N  N   . LYS A 1 139 ? 9.182   -13.888 21.074  1.00 30.07 ? 140 LYS A N   1 
ATOM   1143 C  CA  . LYS A 1 139 ? 8.228   -14.691 20.323  1.00 34.59 ? 140 LYS A CA  1 
ATOM   1144 C  C   . LYS A 1 139 ? 7.552   -13.842 19.252  1.00 30.71 ? 140 LYS A C   1 
ATOM   1145 O  O   . LYS A 1 139 ? 7.361   -14.303 18.112  1.00 30.13 ? 140 LYS A O   1 
ATOM   1146 C  CB  . LYS A 1 139 ? 7.201   -15.363 21.240  1.00 38.17 ? 140 LYS A CB  1 
ATOM   1147 C  CG  . LYS A 1 139 ? 5.766   -15.264 20.749  1.00 40.60 ? 140 LYS A CG  1 
ATOM   1148 C  CD  . LYS A 1 139 ? 4.786   -15.903 21.717  1.00 37.01 ? 140 LYS A CD  1 
ATOM   1149 C  CE  . LYS A 1 139 ? 4.768   -15.182 23.009  1.00 42.59 ? 140 LYS A CE  1 
ATOM   1150 N  NZ  . LYS A 1 139 ? 4.058   -13.927 22.713  1.00 46.24 ? 140 LYS A NZ  1 
ATOM   1151 N  N   . TRP A 1 140 ? 7.254   -12.568 19.557  1.00 29.17 ? 141 TRP A N   1 
ATOM   1152 C  CA  . TRP A 1 140 ? 6.626   -11.767 18.507  1.00 25.19 ? 141 TRP A CA  1 
ATOM   1153 C  C   . TRP A 1 140 ? 7.599   -11.232 17.451  1.00 25.89 ? 141 TRP A C   1 
ATOM   1154 O  O   . TRP A 1 140 ? 7.166   -10.965 16.326  1.00 30.15 ? 141 TRP A O   1 
ATOM   1155 C  CB  . TRP A 1 140 ? 5.804   -10.637 19.122  1.00 24.49 ? 141 TRP A CB  1 
ATOM   1156 C  CG  . TRP A 1 140 ? 4.506   -11.195 19.594  1.00 24.48 ? 141 TRP A CG  1 
ATOM   1157 C  CD1 . TRP A 1 140 ? 4.205   -11.640 20.852  1.00 28.02 ? 141 TRP A CD1 1 
ATOM   1158 C  CD2 . TRP A 1 140 ? 3.359   -11.464 18.785  1.00 21.63 ? 141 TRP A CD2 1 
ATOM   1159 N  NE1 . TRP A 1 140 ? 2.920   -12.135 20.879  1.00 26.61 ? 141 TRP A NE1 1 
ATOM   1160 C  CE2 . TRP A 1 140 ? 2.384   -12.043 19.620  1.00 22.43 ? 141 TRP A CE2 1 
ATOM   1161 C  CE3 . TRP A 1 140 ? 3.061   -11.269 17.431  1.00 24.49 ? 141 TRP A CE3 1 
ATOM   1162 C  CZ2 . TRP A 1 140 ? 1.123   -12.401 19.154  1.00 24.41 ? 141 TRP A CZ2 1 
ATOM   1163 C  CZ3 . TRP A 1 140 ? 1.807   -11.618 16.967  1.00 27.63 ? 141 TRP A CZ3 1 
ATOM   1164 C  CH2 . TRP A 1 140 ? 0.853   -12.187 17.828  1.00 23.68 ? 141 TRP A CH2 1 
ATOM   1165 N  N   . GLU A 1 141 ? 8.892   -11.094 17.761  1.00 31.81 ? 142 GLU A N   1 
ATOM   1166 C  CA  . GLU A 1 141 ? 9.873   -10.790 16.717  1.00 32.64 ? 142 GLU A CA  1 
ATOM   1167 C  C   . GLU A 1 141 ? 9.946   -11.923 15.701  1.00 32.36 ? 142 GLU A C   1 
ATOM   1168 O  O   . GLU A 1 141 ? 9.960   -11.697 14.474  1.00 32.68 ? 142 GLU A O   1 
ATOM   1169 C  CB  . GLU A 1 141 ? 11.239  -10.546 17.357  1.00 33.69 ? 142 GLU A CB  1 
ATOM   1170 C  CG  . GLU A 1 141 ? 11.428  -9.143  17.905  1.00 36.38 ? 142 GLU A CG  1 
ATOM   1171 C  CD  . GLU A 1 141 ? 12.709  -8.993  18.715  1.00 43.10 ? 142 GLU A CD  1 
ATOM   1172 O  OE1 . GLU A 1 141 ? 13.503  -9.960  18.781  1.00 47.01 ? 142 GLU A OE1 1 
ATOM   1173 O  OE2 . GLU A 1 141 ? 12.930  -7.902  19.274  1.00 45.94 ? 142 GLU A OE2 1 
ATOM   1174 N  N   . GLU A 1 142 ? 9.975   -13.161 16.198  1.00 32.24 ? 143 GLU A N   1 
ATOM   1175 C  CA  . GLU A 1 142 ? 9.979   -14.301 15.289  1.00 35.02 ? 143 GLU A CA  1 
ATOM   1176 C  C   . GLU A 1 142 ? 8.703   -14.315 14.449  1.00 36.31 ? 143 GLU A C   1 
ATOM   1177 O  O   . GLU A 1 142 ? 8.753   -14.425 13.210  1.00 35.63 ? 143 GLU A O   1 
ATOM   1178 C  CB  . GLU A 1 142 ? 10.138  -15.587 16.106  1.00 40.45 ? 143 GLU A CB  1 
ATOM   1179 C  CG  . GLU A 1 142 ? 11.564  -15.770 16.647  1.00 42.14 ? 143 GLU A CG  1 
ATOM   1180 C  CD  . GLU A 1 142 ? 11.616  -16.568 17.947  1.00 49.36 ? 143 GLU A CD  1 
ATOM   1181 O  OE1 . GLU A 1 142 ? 10.639  -17.290 18.239  1.00 50.74 ? 143 GLU A OE1 1 
ATOM   1182 O  OE2 . GLU A 1 142 ? 12.626  -16.467 18.682  1.00 52.85 ? 143 GLU A OE2 1 
ATOM   1183 N  N   . LYS A 1 143 ? 7.553   -14.117 15.105  1.00 36.48 ? 144 LYS A N   1 
ATOM   1184 C  CA  . LYS A 1 143 ? 6.279   -14.130 14.395  1.00 27.43 ? 144 LYS A CA  1 
ATOM   1185 C  C   . LYS A 1 143 ? 6.220   -13.039 13.330  1.00 29.30 ? 144 LYS A C   1 
ATOM   1186 O  O   . LYS A 1 143 ? 5.693   -13.266 12.238  1.00 35.12 ? 144 LYS A O   1 
ATOM   1187 C  CB  . LYS A 1 143 ? 5.128   -13.974 15.392  1.00 32.61 ? 144 LYS A CB  1 
ATOM   1188 C  CG  . LYS A 1 143 ? 4.689   -15.287 16.002  1.00 38.01 ? 144 LYS A CG  1 
ATOM   1189 C  CD  . LYS A 1 143 ? 3.512   -15.124 16.937  1.00 34.87 ? 144 LYS A CD  1 
ATOM   1190 C  CE  . LYS A 1 143 ? 2.505   -16.245 16.666  1.00 44.98 ? 144 LYS A CE  1 
ATOM   1191 N  NZ  . LYS A 1 143 ? 1.535   -15.902 15.578  1.00 44.01 ? 144 LYS A NZ  1 
ATOM   1192 N  N   . LEU A 1 144 ? 6.738   -11.843 13.632  1.00 29.87 ? 145 LEU A N   1 
ATOM   1193 C  CA  . LEU A 1 144 ? 6.781   -10.772 12.638  1.00 28.62 ? 145 LEU A CA  1 
ATOM   1194 C  C   . LEU A 1 144 ? 7.582   -11.193 11.417  1.00 30.19 ? 145 LEU A C   1 
ATOM   1195 O  O   . LEU A 1 144 ? 7.154   -10.973 10.273  1.00 28.05 ? 145 LEU A O   1 
ATOM   1196 C  CB  . LEU A 1 144 ? 7.369   -9.496  13.249  1.00 26.79 ? 145 LEU A CB  1 
ATOM   1197 C  CG  . LEU A 1 144 ? 7.420   -8.273  12.314  1.00 23.85 ? 145 LEU A CG  1 
ATOM   1198 C  CD1 . LEU A 1 144 ? 7.277   -6.968  13.042  1.00 27.67 ? 145 LEU A CD1 1 
ATOM   1199 C  CD2 . LEU A 1 144 ? 8.764   -8.263  11.596  1.00 28.62 ? 145 LEU A CD2 1 
ATOM   1200 N  N   . LYS A 1 145 ? 8.772   -11.763 11.644  1.00 29.28 ? 146 LYS A N   1 
ATOM   1201 C  CA  . LYS A 1 145 ? 9.591   -12.194 10.512  1.00 34.62 ? 146 LYS A CA  1 
ATOM   1202 C  C   . LYS A 1 145 ? 8.811   -13.148 9.611   1.00 34.97 ? 146 LYS A C   1 
ATOM   1203 O  O   . LYS A 1 145 ? 8.752   -12.960 8.383   1.00 35.76 ? 146 LYS A O   1 
ATOM   1204 C  CB  . LYS A 1 145 ? 10.887  -12.843 11.005  1.00 31.30 ? 146 LYS A CB  1 
ATOM   1205 C  CG  . LYS A 1 145 ? 11.895  -13.091 9.889   1.00 42.56 ? 146 LYS A CG  1 
ATOM   1206 C  CD  . LYS A 1 145 ? 13.331  -12.842 10.335  1.00 49.10 ? 146 LYS A CD  1 
ATOM   1207 C  CE  . LYS A 1 145 ? 14.305  -13.485 9.357   1.00 51.74 ? 146 LYS A CE  1 
ATOM   1208 N  NZ  . LYS A 1 145 ? 13.673  -14.654 8.679   1.00 47.26 ? 146 LYS A NZ  1 
ATOM   1209 N  N   . LYS A 1 146 ? 8.160   -14.152 10.212  1.00 30.46 ? 147 LYS A N   1 
ATOM   1210 C  CA  . LYS A 1 146 ? 7.400   -15.115 9.404   1.00 34.77 ? 147 LYS A CA  1 
ATOM   1211 C  C   . LYS A 1 146 ? 6.238   -14.436 8.688   1.00 37.80 ? 147 LYS A C   1 
ATOM   1212 O  O   . LYS A 1 146 ? 6.031   -14.648 7.489   1.00 38.22 ? 147 LYS A O   1 
ATOM   1213 C  CB  . LYS A 1 146 ? 6.861   -16.304 10.227  1.00 38.84 ? 147 LYS A CB  1 
ATOM   1214 C  CG  . LYS A 1 146 ? 7.687   -16.927 11.367  1.00 42.94 ? 147 LYS A CG  1 
ATOM   1215 C  CD  . LYS A 1 146 ? 9.148   -16.583 11.326  1.00 44.21 ? 147 LYS A CD  1 
ATOM   1216 C  CE  . LYS A 1 146 ? 9.927   -17.214 12.431  1.00 42.70 ? 147 LYS A CE  1 
ATOM   1217 N  NZ  . LYS A 1 146 ? 11.125  -16.342 12.567  1.00 40.96 ? 147 LYS A NZ  1 
ATOM   1218 N  N   . TYR A 1 147 ? 5.479   -13.595 9.402   1.00 35.14 ? 148 TYR A N   1 
ATOM   1219 C  CA  . TYR A 1 147 ? 4.286   -12.994 8.819   1.00 33.00 ? 148 TYR A CA  1 
ATOM   1220 C  C   . TYR A 1 147 ? 4.642   -12.123 7.620   1.00 38.22 ? 148 TYR A C   1 
ATOM   1221 O  O   . TYR A 1 147 ? 3.958   -12.158 6.587   1.00 37.49 ? 148 TYR A O   1 
ATOM   1222 C  CB  . TYR A 1 147 ? 3.546   -12.168 9.874   1.00 31.16 ? 148 TYR A CB  1 
ATOM   1223 C  CG  . TYR A 1 147 ? 2.701   -12.983 10.830  1.00 31.87 ? 148 TYR A CG  1 
ATOM   1224 C  CD1 . TYR A 1 147 ? 2.017   -14.115 10.395  1.00 39.22 ? 148 TYR A CD1 1 
ATOM   1225 C  CD2 . TYR A 1 147 ? 2.577   -12.618 12.166  1.00 37.57 ? 148 TYR A CD2 1 
ATOM   1226 C  CE1 . TYR A 1 147 ? 1.242   -14.865 11.271  1.00 36.21 ? 148 TYR A CE1 1 
ATOM   1227 C  CE2 . TYR A 1 147 ? 1.800   -13.354 13.043  1.00 38.22 ? 148 TYR A CE2 1 
ATOM   1228 C  CZ  . TYR A 1 147 ? 1.131   -14.478 12.588  1.00 37.83 ? 148 TYR A CZ  1 
ATOM   1229 O  OH  . TYR A 1 147 ? 0.358   -15.223 13.451  1.00 43.16 ? 148 TYR A OH  1 
ATOM   1230 N  N   . LEU A 1 148 ? 5.713   -11.334 7.737   1.00 35.42 ? 149 LEU A N   1 
ATOM   1231 C  CA  . LEU A 1 148 ? 6.122   -10.496 6.615   1.00 31.87 ? 149 LEU A CA  1 
ATOM   1232 C  C   . LEU A 1 148 ? 6.712   -11.320 5.476   1.00 41.62 ? 149 LEU A C   1 
ATOM   1233 O  O   . LEU A 1 148 ? 6.654   -10.893 4.317   1.00 35.81 ? 149 LEU A O   1 
ATOM   1234 C  CB  . LEU A 1 148 ? 7.105   -9.414  7.070   1.00 36.51 ? 149 LEU A CB  1 
ATOM   1235 C  CG  . LEU A 1 148 ? 6.733   -8.582  8.307   1.00 36.42 ? 149 LEU A CG  1 
ATOM   1236 C  CD1 . LEU A 1 148 ? 7.505   -7.286  8.305   1.00 40.02 ? 149 LEU A CD1 1 
ATOM   1237 C  CD2 . LEU A 1 148 ? 5.246   -8.288  8.313   1.00 36.60 ? 149 LEU A CD2 1 
ATOM   1238 N  N   . GLU A 1 149 ? 7.283   -12.492 5.772   1.00 37.35 ? 150 GLU A N   1 
ATOM   1239 C  CA  . GLU A 1 149 ? 7.700   -13.369 4.680   1.00 42.73 ? 150 GLU A CA  1 
ATOM   1240 C  C   . GLU A 1 149 ? 6.516   -14.074 4.023   1.00 41.85 ? 150 GLU A C   1 
ATOM   1241 O  O   . GLU A 1 149 ? 6.639   -14.538 2.884   1.00 50.61 ? 150 GLU A O   1 
ATOM   1242 C  CB  . GLU A 1 149 ? 8.710   -14.394 5.198   1.00 42.76 ? 150 GLU A CB  1 
ATOM   1243 C  CG  . GLU A 1 149 ? 10.080  -13.801 5.513   1.00 44.05 ? 150 GLU A CG  1 
ATOM   1244 C  CD  . GLU A 1 149 ? 11.011  -14.790 6.190   1.00 48.97 ? 150 GLU A CD  1 
ATOM   1245 O  OE1 . GLU A 1 149 ? 10.580  -15.935 6.448   1.00 52.21 ? 150 GLU A OE1 1 
ATOM   1246 O  OE2 . GLU A 1 149 ? 12.175  -14.422 6.462   1.00 51.04 ? 150 GLU A OE2 1 
ATOM   1247 N  N   . GLU A 1 150 ? 5.376   -14.146 4.707   1.00 43.30 ? 151 GLU A N   1 
ATOM   1248 C  CA  . GLU A 1 150 ? 4.227   -14.935 4.275   1.00 46.56 ? 151 GLU A CA  1 
ATOM   1249 C  C   . GLU A 1 150 ? 3.170   -14.123 3.537   1.00 44.76 ? 151 GLU A C   1 
ATOM   1250 O  O   . GLU A 1 150 ? 2.506   -14.658 2.640   1.00 44.10 ? 151 GLU A O   1 
ATOM   1251 C  CB  . GLU A 1 150 ? 3.572   -15.600 5.493   1.00 47.03 ? 151 GLU A CB  1 
ATOM   1252 C  CG  . GLU A 1 150 ? 4.359   -16.761 6.096   1.00 49.78 ? 151 GLU A CG  1 
ATOM   1253 C  CD  . GLU A 1 150 ? 3.682   -17.330 7.330   1.00 51.94 ? 151 GLU A CD  1 
ATOM   1254 O  OE1 . GLU A 1 150 ? 2.633   -16.778 7.732   1.00 48.81 ? 151 GLU A OE1 1 
ATOM   1255 O  OE2 . GLU A 1 150 ? 4.207   -18.309 7.905   1.00 53.64 ? 151 GLU A OE2 1 
ATOM   1256 N  N   . VAL A 1 151 ? 2.997   -12.850 3.886   1.00 39.32 ? 152 VAL A N   1 
ATOM   1257 C  CA  . VAL A 1 151 ? 1.847   -12.078 3.423   1.00 33.95 ? 152 VAL A CA  1 
ATOM   1258 C  C   . VAL A 1 151 ? 2.129   -11.538 2.023   1.00 37.53 ? 152 VAL A C   1 
ATOM   1259 O  O   . VAL A 1 151 ? 2.995   -10.684 1.826   1.00 37.51 ? 152 VAL A O   1 
ATOM   1260 C  CB  . VAL A 1 151 ? 1.486   -10.958 4.411   1.00 29.09 ? 152 VAL A CB  1 
ATOM   1261 C  CG1 . VAL A 1 151 ? 2.625   -9.971  4.593   1.00 30.69 ? 152 VAL A CG1 1 
ATOM   1262 C  CG2 . VAL A 1 151 ? 0.242   -10.249 3.945   1.00 25.56 ? 152 VAL A CG2 1 
ATOM   1263 N  N   . LYS A 1 152 ? 1.394   -12.055 1.036   1.00 29.64 ? 153 LYS A N   1 
ATOM   1264 C  CA  . LYS A 1 152 ? 1.583   -11.661 -0.351  1.00 35.63 ? 153 LYS A CA  1 
ATOM   1265 C  C   . LYS A 1 152 ? 0.332   -11.102 -1.001  1.00 39.36 ? 153 LYS A C   1 
ATOM   1266 O  O   . LYS A 1 152 ? 0.446   -10.418 -2.025  1.00 41.48 ? 153 LYS A O   1 
ATOM   1267 C  CB  . LYS A 1 152 ? 2.061   -12.858 -1.187  1.00 40.01 ? 153 LYS A CB  1 
ATOM   1268 C  CG  . LYS A 1 152 ? 3.429   -13.381 -0.814  1.00 46.76 ? 153 LYS A CG  1 
ATOM   1269 C  CD  . LYS A 1 152 ? 3.744   -14.596 -1.652  1.00 51.97 ? 153 LYS A CD  1 
ATOM   1270 C  CE  . LYS A 1 152 ? 5.108   -15.185 -1.341  1.00 59.81 ? 153 LYS A CE  1 
ATOM   1271 N  NZ  . LYS A 1 152 ? 5.352   -16.403 -2.171  1.00 59.91 ? 153 LYS A NZ  1 
ATOM   1272 N  N   . THR A 1 153 ? -0.851  -11.392 -0.460  1.00 30.72 ? 154 THR A N   1 
ATOM   1273 C  CA  . THR A 1 153 ? -2.118  -10.953 -1.022  1.00 32.28 ? 154 THR A CA  1 
ATOM   1274 C  C   . THR A 1 153 ? -2.988  -10.377 0.085   1.00 30.43 ? 154 THR A C   1 
ATOM   1275 O  O   . THR A 1 153 ? -2.715  -10.554 1.273   1.00 29.35 ? 154 THR A O   1 
ATOM   1276 C  CB  . THR A 1 153 ? -2.890  -12.102 -1.671  1.00 28.24 ? 154 THR A CB  1 
ATOM   1277 O  OG1 . THR A 1 153 ? -3.341  -12.979 -0.632  1.00 27.37 ? 154 THR A OG1 1 
ATOM   1278 C  CG2 . THR A 1 153 ? -1.997  -12.892 -2.598  1.00 35.15 ? 154 THR A CG2 1 
ATOM   1279 N  N   . LYS A 1 154 ? -4.090  -9.751  -0.335  1.00 32.01 ? 155 LYS A N   1 
ATOM   1280 C  CA  . LYS A 1 154 ? -5.060  -9.201  0.608   1.00 32.18 ? 155 LYS A CA  1 
ATOM   1281 C  C   . LYS A 1 154 ? -5.751  -10.298 1.415   1.00 30.56 ? 155 LYS A C   1 
ATOM   1282 O  O   . LYS A 1 154 ? -6.022  -10.119 2.614   1.00 27.16 ? 155 LYS A O   1 
ATOM   1283 C  CB  . LYS A 1 154 ? -6.085  -8.368  -0.153  1.00 42.56 ? 155 LYS A CB  1 
ATOM   1284 C  CG  . LYS A 1 154 ? -7.134  -7.692  0.702   1.00 33.78 ? 155 LYS A CG  1 
ATOM   1285 C  CD  . LYS A 1 154 ? -8.031  -6.883  -0.209  1.00 40.73 ? 155 LYS A CD  1 
ATOM   1286 C  CE  . LYS A 1 154 ? -9.168  -6.237  0.537   1.00 41.36 ? 155 LYS A CE  1 
ATOM   1287 N  NZ  . LYS A 1 154 ? -10.033 -5.444  -0.389  1.00 50.15 ? 155 LYS A NZ  1 
ATOM   1288 N  N   . GLU A 1 155 ? -6.068  -11.434 0.780   1.00 28.69 ? 156 GLU A N   1 
ATOM   1289 C  CA  . GLU A 1 155 ? -6.654  -12.537 1.535   1.00 28.45 ? 156 GLU A CA  1 
ATOM   1290 C  C   . GLU A 1 155 ? -5.696  -13.055 2.603   1.00 24.05 ? 156 GLU A C   1 
ATOM   1291 O  O   . GLU A 1 155 ? -6.105  -13.315 3.746   1.00 27.64 ? 156 GLU A O   1 
ATOM   1292 C  CB  . GLU A 1 155 ? -7.071  -13.658 0.582   1.00 34.69 ? 156 GLU A CB  1 
ATOM   1293 C  CG  . GLU A 1 155 ? -8.242  -14.544 1.041   1.00 42.81 ? 156 GLU A CG  1 
ATOM   1294 C  CD  . GLU A 1 155 ? -9.505  -13.797 1.455   1.00 53.11 ? 156 GLU A CD  1 
ATOM   1295 O  OE1 . GLU A 1 155 ? -10.549 -14.016 0.804   1.00 54.26 ? 156 GLU A OE1 1 
ATOM   1296 O  OE2 . GLU A 1 155 ? -9.492  -13.065 2.472   1.00 60.19 ? 156 GLU A OE2 1 
ATOM   1297 N  N   . GLU A 1 156 ? -4.413  -13.200 2.254   1.00 26.09 ? 157 GLU A N   1 
ATOM   1298 C  CA  . GLU A 1 156 ? -3.425  -13.656 3.224   1.00 22.10 ? 157 GLU A CA  1 
ATOM   1299 C  C   . GLU A 1 156 ? -3.254  -12.634 4.343   1.00 22.70 ? 157 GLU A C   1 
ATOM   1300 O  O   . GLU A 1 156 ? -3.100  -13.003 5.517   1.00 25.18 ? 157 GLU A O   1 
ATOM   1301 C  CB  . GLU A 1 156 ? -2.094  -13.936 2.521   1.00 29.84 ? 157 GLU A CB  1 
ATOM   1302 C  CG  . GLU A 1 156 ? -2.133  -15.220 1.707   1.00 22.97 ? 157 GLU A CG  1 
ATOM   1303 C  CD  . GLU A 1 156 ? -0.914  -15.453 0.824   1.00 26.35 ? 157 GLU A CD  1 
ATOM   1304 O  OE1 . GLU A 1 156 ? -0.152  -14.508 0.525   1.00 30.24 ? 157 GLU A OE1 1 
ATOM   1305 O  OE2 . GLU A 1 156 ? -0.750  -16.610 0.394   1.00 28.23 ? 157 GLU A OE2 1 
ATOM   1306 N  N   . ALA A 1 157 ? -3.295  -11.343 4.000   1.00 19.95 ? 158 ALA A N   1 
ATOM   1307 C  CA  . ALA A 1 157 ? -3.172  -10.308 5.029   1.00 21.29 ? 158 ALA A CA  1 
ATOM   1308 C  C   . ALA A 1 157 ? -4.356  -10.348 5.987   1.00 24.71 ? 158 ALA A C   1 
ATOM   1309 O  O   . ALA A 1 157 ? -4.185  -10.202 7.202   1.00 22.87 ? 158 ALA A O   1 
ATOM   1310 C  CB  . ALA A 1 157 ? -3.056  -8.933  4.377   1.00 23.32 ? 158 ALA A CB  1 
ATOM   1311 N  N   . LEU A 1 158 ? -5.569  -10.539 5.458   1.00 23.50 ? 159 LEU A N   1 
ATOM   1312 C  CA  . LEU A 1 158 ? -6.747  -10.620 6.320   1.00 23.77 ? 159 LEU A CA  1 
ATOM   1313 C  C   . LEU A 1 158 ? -6.670  -11.826 7.258   1.00 25.35 ? 159 LEU A C   1 
ATOM   1314 O  O   . LEU A 1 158 ? -7.026  -11.727 8.443   1.00 24.01 ? 159 LEU A O   1 
ATOM   1315 C  CB  . LEU A 1 158 ? -8.010  -10.658 5.457   1.00 30.45 ? 159 LEU A CB  1 
ATOM   1316 C  CG  . LEU A 1 158 ? -8.363  -9.367  4.701   1.00 27.21 ? 159 LEU A CG  1 
ATOM   1317 C  CD1 . LEU A 1 158 ? -9.547  -9.582  3.775   1.00 34.49 ? 159 LEU A CD1 1 
ATOM   1318 C  CD2 . LEU A 1 158 ? -8.724  -8.302  5.706   1.00 33.94 ? 159 LEU A CD2 1 
ATOM   1319 N  N   . LYS A 1 159 ? -6.198  -12.969 6.759   1.00 21.52 ? 160 LYS A N   1 
ATOM   1320 C  CA  . LYS A 1 159 ? -6.070  -14.152 7.617   1.00 22.60 ? 160 LYS A CA  1 
ATOM   1321 C  C   . LYS A 1 159 ? -5.022  -13.947 8.710   1.00 24.14 ? 160 LYS A C   1 
ATOM   1322 O  O   . LYS A 1 159 ? -5.236  -14.326 9.879   1.00 26.08 ? 160 LYS A O   1 
ATOM   1323 C  CB  . LYS A 1 159 ? -5.715  -15.383 6.777   1.00 25.82 ? 160 LYS A CB  1 
ATOM   1324 C  CG  . LYS A 1 159 ? -6.693  -15.691 5.669   1.00 34.33 ? 160 LYS A CG  1 
ATOM   1325 C  CD  . LYS A 1 159 ? -6.448  -17.093 5.109   1.00 38.78 ? 160 LYS A CD  1 
ATOM   1326 C  CE  . LYS A 1 159 ? -6.799  -17.176 3.632   1.00 34.79 ? 160 LYS A CE  1 
ATOM   1327 N  NZ  . LYS A 1 159 ? -5.592  -16.809 2.811   1.00 35.89 ? 160 LYS A NZ  1 
ATOM   1328 N  N   . ILE A 1 160 ? -3.870  -13.376 8.341   1.00 22.09 ? 161 ILE A N   1 
ATOM   1329 C  CA  . ILE A 1 160 ? -2.816  -13.129 9.320   1.00 23.73 ? 161 ILE A CA  1 
ATOM   1330 C  C   . ILE A 1 160 ? -3.294  -12.110 10.351  1.00 23.31 ? 161 ILE A C   1 
ATOM   1331 O  O   . ILE A 1 160 ? -3.005  -12.234 11.551  1.00 23.38 ? 161 ILE A O   1 
ATOM   1332 C  CB  . ILE A 1 160 ? -1.527  -12.666 8.610   1.00 24.08 ? 161 ILE A CB  1 
ATOM   1333 C  CG1 . ILE A 1 160 ? -0.823  -13.856 7.933   1.00 26.37 ? 161 ILE A CG1 1 
ATOM   1334 C  CG2 . ILE A 1 160 ? -0.577  -12.006 9.608   1.00 26.65 ? 161 ILE A CG2 1 
ATOM   1335 C  CD1 . ILE A 1 160 ? 0.051   -13.459 6.768   1.00 35.45 ? 161 ILE A CD1 1 
ATOM   1336 N  N   . LEU A 1 161 ? -4.049  -11.105 9.906   1.00 19.92 ? 162 LEU A N   1 
ATOM   1337 C  CA  . LEU A 1 161 ? -4.608  -10.114 10.830  1.00 18.44 ? 162 LEU A CA  1 
ATOM   1338 C  C   . LEU A 1 161 ? -5.485  -10.791 11.869  1.00 21.61 ? 162 LEU A C   1 
ATOM   1339 O  O   . LEU A 1 161 ? -5.390  -10.487 13.064  1.00 22.99 ? 162 LEU A O   1 
ATOM   1340 C  CB  . LEU A 1 161 ? -5.413  -9.077  10.059  1.00 19.78 ? 162 LEU A CB  1 
ATOM   1341 C  CG  . LEU A 1 161 ? -6.116  -8.011  10.909  1.00 27.11 ? 162 LEU A CG  1 
ATOM   1342 C  CD1 . LEU A 1 161 ? -5.093  -7.232  11.689  1.00 27.06 ? 162 LEU A CD1 1 
ATOM   1343 C  CD2 . LEU A 1 161 ? -6.947  -7.099  10.031  1.00 27.66 ? 162 LEU A CD2 1 
ATOM   1344 N  N   . GLU A 1 162 ? -6.359  -11.713 11.425  1.00 24.16 ? 163 GLU A N   1 
ATOM   1345 C  CA  . GLU A 1 162 ? -7.199  -12.435 12.388  1.00 24.39 ? 163 GLU A CA  1 
ATOM   1346 C  C   . GLU A 1 162 ? -6.362  -13.219 13.386  1.00 26.05 ? 163 GLU A C   1 
ATOM   1347 O  O   . GLU A 1 162 ? -6.681  -13.252 14.590  1.00 25.37 ? 163 GLU A O   1 
ATOM   1348 C  CB  . GLU A 1 162 ? -8.150  -13.400 11.677  1.00 27.83 ? 163 GLU A CB  1 
ATOM   1349 C  CG  . GLU A 1 162 ? -8.709  -12.899 10.403  1.00 36.74 ? 163 GLU A CG  1 
ATOM   1350 C  CD  . GLU A 1 162 ? -10.077 -12.318 10.578  1.00 41.39 ? 163 GLU A CD  1 
ATOM   1351 O  OE1 . GLU A 1 162 ? -10.281 -11.622 11.594  1.00 45.17 ? 163 GLU A OE1 1 
ATOM   1352 O  OE2 . GLU A 1 162 ? -10.936 -12.529 9.696   1.00 44.99 ? 163 GLU A OE2 1 
ATOM   1353 N  N   . GLU A 1 163 ? -5.312  -13.889 12.905  1.00 23.35 ? 164 GLU A N   1 
ATOM   1354 C  CA  . GLU A 1 163 ? -4.476  -14.674 13.813  1.00 23.36 ? 164 GLU A CA  1 
ATOM   1355 C  C   . GLU A 1 163 ? -3.817  -13.781 14.849  1.00 24.86 ? 164 GLU A C   1 
ATOM   1356 O  O   . GLU A 1 163 ? -3.785  -14.101 16.047  1.00 23.98 ? 164 GLU A O   1 
ATOM   1357 C  CB  . GLU A 1 163 ? -3.403  -15.442 13.041  1.00 33.43 ? 164 GLU A CB  1 
ATOM   1358 C  CG  . GLU A 1 163 ? -3.900  -16.509 12.085  1.00 34.17 ? 164 GLU A CG  1 
ATOM   1359 C  CD  . GLU A 1 163 ? -2.740  -17.251 11.426  1.00 44.28 ? 164 GLU A CD  1 
ATOM   1360 O  OE1 . GLU A 1 163 ? -2.988  -18.218 10.669  1.00 43.43 ? 164 GLU A OE1 1 
ATOM   1361 O  OE2 . GLU A 1 163 ? -1.573  -16.868 11.675  1.00 44.70 ? 164 GLU A OE2 1 
ATOM   1362 N  N   . ILE A 1 164 ? -3.272  -12.657 14.391  1.00 22.89 ? 165 ILE A N   1 
ATOM   1363 C  CA  . ILE A 1 164 ? -2.609  -11.709 15.286  1.00 18.64 ? 165 ILE A CA  1 
ATOM   1364 C  C   . ILE A 1 164 ? -3.584  -11.225 16.347  1.00 19.61 ? 165 ILE A C   1 
ATOM   1365 O  O   . ILE A 1 164 ? -3.259  -11.178 17.539  1.00 22.29 ? 165 ILE A O   1 
ATOM   1366 C  CB  . ILE A 1 164 ? -2.046  -10.523 14.480  1.00 15.18 ? 165 ILE A CB  1 
ATOM   1367 C  CG1 . ILE A 1 164 ? -0.880  -10.958 13.607  1.00 23.91 ? 165 ILE A CG1 1 
ATOM   1368 C  CG2 . ILE A 1 164 ? -1.626  -9.366  15.421  1.00 20.04 ? 165 ILE A CG2 1 
ATOM   1369 C  CD1 . ILE A 1 164 ? -0.530  -9.886  12.578  1.00 24.05 ? 165 ILE A CD1 1 
ATOM   1370 N  N   . LEU A 1 165 ? -4.779  -10.815 15.916  1.00 19.95 ? 166 LEU A N   1 
ATOM   1371 C  CA  . LEU A 1 165 ? -5.750  -10.254 16.848  1.00 18.54 ? 166 LEU A CA  1 
ATOM   1372 C  C   . LEU A 1 165 ? -6.184  -11.278 17.887  1.00 20.77 ? 166 LEU A C   1 
ATOM   1373 O  O   . LEU A 1 165 ? -6.300  -10.947 19.073  1.00 22.08 ? 166 LEU A O   1 
ATOM   1374 C  CB  . LEU A 1 165 ? -6.955  -9.714  16.077  1.00 24.15 ? 166 LEU A CB  1 
ATOM   1375 C  CG  . LEU A 1 165 ? -6.698  -8.469  15.228  1.00 24.31 ? 166 LEU A CG  1 
ATOM   1376 C  CD1 . LEU A 1 165 ? -7.951  -8.081  14.482  1.00 26.58 ? 166 LEU A CD1 1 
ATOM   1377 C  CD2 . LEU A 1 165 ? -6.256  -7.322  16.125  1.00 24.67 ? 166 LEU A CD2 1 
ATOM   1378 N  N   . LYS A 1 166 ? -6.410  -12.532 17.464  1.00 24.54 ? 167 LYS A N   1 
ATOM   1379 C  CA  . LYS A 1 166 ? -6.754  -13.606 18.403  1.00 20.07 ? 167 LYS A CA  1 
ATOM   1380 C  C   . LYS A 1 166 ? -5.682  -13.788 19.477  1.00 21.50 ? 167 LYS A C   1 
ATOM   1381 O  O   . LYS A 1 166 ? -5.983  -13.808 20.687  1.00 24.66 ? 167 LYS A O   1 
ATOM   1382 C  CB  . LYS A 1 166 ? -6.954  -14.912 17.624  1.00 26.23 ? 167 LYS A CB  1 
ATOM   1383 C  CG  . LYS A 1 166 ? -7.372  -16.098 18.467  1.00 31.25 ? 167 LYS A CG  1 
ATOM   1384 C  CD  . LYS A 1 166 ? -7.316  -17.377 17.636  1.00 30.13 ? 167 LYS A CD  1 
ATOM   1385 C  CE  . LYS A 1 166 ? -8.542  -17.516 16.773  1.00 42.47 ? 167 LYS A CE  1 
ATOM   1386 N  NZ  . LYS A 1 166 ? -9.745  -17.473 17.636  1.00 40.94 ? 167 LYS A NZ  1 
ATOM   1387 N  N   . GLU A 1 167 ? -4.417  -13.913 19.062  1.00 22.94 ? 168 GLU A N   1 
ATOM   1388 C  CA  . GLU A 1 167 ? -3.366  -14.156 20.057  1.00 19.59 ? 168 GLU A CA  1 
ATOM   1389 C  C   . GLU A 1 167 ? -3.143  -12.966 20.975  1.00 21.01 ? 168 GLU A C   1 
ATOM   1390 O  O   . GLU A 1 167 ? -2.967  -13.139 22.192  1.00 20.50 ? 168 GLU A O   1 
ATOM   1391 C  CB  . GLU A 1 167 ? -2.054  -14.539 19.395  1.00 25.32 ? 168 GLU A CB  1 
ATOM   1392 C  CG  . GLU A 1 167 ? -2.206  -15.475 18.246  1.00 33.79 ? 168 GLU A CG  1 
ATOM   1393 C  CD  . GLU A 1 167 ? -0.963  -16.283 18.030  1.00 38.69 ? 168 GLU A CD  1 
ATOM   1394 O  OE1 . GLU A 1 167 ? 0.038   -16.041 18.731  1.00 45.32 ? 168 GLU A OE1 1 
ATOM   1395 O  OE2 . GLU A 1 167 ? -1.001  -17.198 17.200  1.00 50.06 ? 168 GLU A OE2 1 
ATOM   1396 N  N   . ARG A 1 168 ? -3.125  -11.751 20.421  1.00 20.63 ? 169 ARG A N   1 
ATOM   1397 C  CA  . ARG A 1 168 ? -2.908  -10.615 21.302  1.00 16.36 ? 169 ARG A CA  1 
ATOM   1398 C  C   . ARG A 1 168 ? -4.085  -10.415 22.244  1.00 18.66 ? 169 ARG A C   1 
ATOM   1399 O  O   . ARG A 1 168 ? -3.887  -9.961  23.378  1.00 20.06 ? 169 ARG A O   1 
ATOM   1400 C  CB  . ARG A 1 168 ? -2.628  -9.348  20.486  1.00 18.56 ? 169 ARG A CB  1 
ATOM   1401 C  CG  . ARG A 1 168 ? -1.278  -9.360  19.761  1.00 22.37 ? 169 ARG A CG  1 
ATOM   1402 C  CD  . ARG A 1 168 ? -0.085  -9.505  20.719  1.00 21.71 ? 169 ARG A CD  1 
ATOM   1403 N  NE  . ARG A 1 168 ? 1.147   -8.986  20.131  1.00 18.58 ? 169 ARG A NE  1 
ATOM   1404 C  CZ  . ARG A 1 168 ? 2.291   -8.840  20.788  1.00 23.05 ? 169 ARG A CZ  1 
ATOM   1405 N  NH1 . ARG A 1 168 ? 2.428   -9.236  22.051  1.00 24.20 ? 169 ARG A NH1 1 
ATOM   1406 N  NH2 . ARG A 1 168 ? 3.329   -8.289  20.165  1.00 24.48 ? 169 ARG A NH2 1 
ATOM   1407 N  N   . LYS A 1 169 ? -5.303  -10.746 21.809  1.00 21.71 ? 170 LYS A N   1 
ATOM   1408 C  CA  . LYS A 1 169 ? -6.463  -10.706 22.699  1.00 17.83 ? 170 LYS A CA  1 
ATOM   1409 C  C   . LYS A 1 169 ? -6.258  -11.618 23.900  1.00 21.47 ? 170 LYS A C   1 
ATOM   1410 O  O   . LYS A 1 169 ? -6.535  -11.225 25.041  1.00 20.72 ? 170 LYS A O   1 
ATOM   1411 C  CB  . LYS A 1 169 ? -7.698  -11.144 21.922  1.00 27.27 ? 170 LYS A CB  1 
ATOM   1412 C  CG  . LYS A 1 169 ? -8.936  -11.376 22.761  1.00 30.17 ? 170 LYS A CG  1 
ATOM   1413 C  CD  . LYS A 1 169 ? -9.768  -12.435 22.055  1.00 40.38 ? 170 LYS A CD  1 
ATOM   1414 C  CE  . LYS A 1 169 ? -10.893 -11.867 21.254  1.00 41.08 ? 170 LYS A CE  1 
ATOM   1415 N  NZ  . LYS A 1 169 ? -12.067 -12.784 21.276  1.00 46.59 ? 170 LYS A NZ  1 
ATOM   1416 N  N   . GLU A 1 170 ? -5.759  -12.834 23.652  1.00 22.31 ? 171 GLU A N   1 
ATOM   1417 C  CA  . GLU A 1 170 ? -5.459  -13.754 24.746  1.00 23.58 ? 171 GLU A CA  1 
ATOM   1418 C  C   . GLU A 1 170 ? -4.428  -13.161 25.701  1.00 20.53 ? 171 GLU A C   1 
ATOM   1419 O  O   . GLU A 1 170 ? -4.552  -13.291 26.930  1.00 21.34 ? 171 GLU A O   1 
ATOM   1420 C  CB  . GLU A 1 170 ? -4.952  -15.076 24.168  1.00 27.46 ? 171 GLU A CB  1 
ATOM   1421 C  CG  . GLU A 1 170 ? -6.052  -16.085 24.005  1.00 39.05 ? 171 GLU A CG  1 
ATOM   1422 C  CD  . GLU A 1 170 ? -6.602  -16.551 25.328  1.00 37.67 ? 171 GLU A CD  1 
ATOM   1423 O  OE1 . GLU A 1 170 ? -5.796  -16.925 26.214  1.00 45.86 ? 171 GLU A OE1 1 
ATOM   1424 O  OE2 . GLU A 1 170 ? -7.835  -16.500 25.489  1.00 41.66 ? 171 GLU A OE2 1 
ATOM   1425 N  N   . GLU A 1 171 ? -3.406  -12.498 25.154  1.00 17.59 ? 172 GLU A N   1 
ATOM   1426 C  CA  . GLU A 1 171 ? -2.366  -11.936 26.014  1.00 21.36 ? 172 GLU A CA  1 
ATOM   1427 C  C   . GLU A 1 171 ? -2.913  -10.782 26.854  1.00 21.99 ? 172 GLU A C   1 
ATOM   1428 O  O   . GLU A 1 171 ? -2.552  -10.625 28.029  1.00 20.73 ? 172 GLU A O   1 
ATOM   1429 C  CB  . GLU A 1 171 ? -1.177  -11.475 25.167  1.00 20.36 ? 172 GLU A CB  1 
ATOM   1430 C  CG  . GLU A 1 171 ? -0.474  -12.601 24.421  1.00 25.41 ? 172 GLU A CG  1 
ATOM   1431 C  CD  . GLU A 1 171 ? 0.708   -12.100 23.634  1.00 31.01 ? 172 GLU A CD  1 
ATOM   1432 O  OE1 . GLU A 1 171 ? 0.809   -10.867 23.505  1.00 28.03 ? 172 GLU A OE1 1 
ATOM   1433 O  OE2 . GLU A 1 171 ? 1.457   -12.929 23.053  1.00 29.12 ? 172 GLU A OE2 1 
ATOM   1434 N  N   . LEU A 1 172 ? -3.772  -9.947  26.265  1.00 19.25 ? 173 LEU A N   1 
ATOM   1435 C  CA  . LEU A 1 172 ? -4.322  -8.817  27.010  1.00 18.57 ? 173 LEU A CA  1 
ATOM   1436 C  C   . LEU A 1 172 ? -5.232  -9.317  28.122  1.00 21.50 ? 173 LEU A C   1 
ATOM   1437 O  O   . LEU A 1 172 ? -5.226  -8.771  29.234  1.00 20.45 ? 173 LEU A O   1 
ATOM   1438 C  CB  . LEU A 1 172 ? -5.057  -7.875  26.048  1.00 21.10 ? 173 LEU A CB  1 
ATOM   1439 C  CG  . LEU A 1 172 ? -4.090  -7.102  25.133  1.00 22.78 ? 173 LEU A CG  1 
ATOM   1440 C  CD1 . LEU A 1 172 ? -4.830  -6.382  24.041  1.00 22.20 ? 173 LEU A CD1 1 
ATOM   1441 C  CD2 . LEU A 1 172 ? -3.245  -6.120  25.929  1.00 19.73 ? 173 LEU A CD2 1 
ATOM   1442 N  N   . GLU A 1 173 ? -6.003  -10.380 27.842  1.00 20.93 ? 174 GLU A N   1 
ATOM   1443 C  CA  . GLU A 1 173 ? -6.809  -10.996 28.893  1.00 23.42 ? 174 GLU A CA  1 
ATOM   1444 C  C   . GLU A 1 173 ? -5.942  -11.528 30.020  1.00 23.71 ? 174 GLU A C   1 
ATOM   1445 O  O   . GLU A 1 173 ? -6.279  -11.363 31.205  1.00 24.35 ? 174 GLU A O   1 
ATOM   1446 C  CB  . GLU A 1 173 ? -7.634  -12.140 28.328  1.00 22.20 ? 174 GLU A CB  1 
ATOM   1447 C  CG  . GLU A 1 173 ? -8.681  -11.808 27.331  1.00 26.24 ? 174 GLU A CG  1 
ATOM   1448 C  CD  . GLU A 1 173 ? -9.325  -13.094 26.802  1.00 37.18 ? 174 GLU A CD  1 
ATOM   1449 O  OE1 . GLU A 1 173 ? -9.616  -13.994 27.631  1.00 39.16 ? 174 GLU A OE1 1 
ATOM   1450 O  OE2 . GLU A 1 173 ? -9.524  -13.214 25.573  1.00 40.57 ? 174 GLU A OE2 1 
ATOM   1451 N  N   . LYS A 1 174 ? -4.837  -12.195 29.675  1.00 19.83 ? 175 LYS A N   1 
ATOM   1452 C  CA  . LYS A 1 174 ? -3.980  -12.740 30.725  1.00 25.40 ? 175 LYS A CA  1 
ATOM   1453 C  C   . LYS A 1 174 ? -3.426  -11.621 31.597  1.00 27.58 ? 175 LYS A C   1 
ATOM   1454 O  O   . LYS A 1 174 ? -3.199  -11.816 32.796  1.00 24.56 ? 175 LYS A O   1 
ATOM   1455 C  CB  . LYS A 1 174 ? -2.826  -13.545 30.125  1.00 27.76 ? 175 LYS A CB  1 
ATOM   1456 C  CG  . LYS A 1 174 ? -1.547  -12.722 30.085  1.00 36.29 ? 175 LYS A CG  1 
ATOM   1457 C  CD  . LYS A 1 174 ? -0.637  -12.973 28.906  1.00 40.50 ? 175 LYS A CD  1 
ATOM   1458 C  CE  . LYS A 1 174 ? 0.320   -11.801 28.818  1.00 25.16 ? 175 LYS A CE  1 
ATOM   1459 N  NZ  . LYS A 1 174 ? 1.392   -11.960 27.817  1.00 46.96 ? 175 LYS A NZ  1 
ATOM   1460 N  N   . LEU A 1 175 ? -3.209  -10.437 31.017  1.00 23.76 ? 176 LEU A N   1 
ATOM   1461 C  CA  . LEU A 1 175 ? -2.684  -9.314  31.780  1.00 24.94 ? 176 LEU A CA  1 
ATOM   1462 C  C   . LEU A 1 175 ? -3.740  -8.698  32.681  1.00 25.68 ? 176 LEU A C   1 
ATOM   1463 O  O   . LEU A 1 175 ? -3.419  -7.821  33.491  1.00 24.82 ? 176 LEU A O   1 
ATOM   1464 C  CB  . LEU A 1 175 ? -2.101  -8.267  30.818  1.00 20.38 ? 176 LEU A CB  1 
ATOM   1465 C  CG  . LEU A 1 175 ? -0.781  -8.768  30.229  1.00 27.40 ? 176 LEU A CG  1 
ATOM   1466 C  CD1 . LEU A 1 175 ? -0.262  -7.897  29.091  1.00 23.24 ? 176 LEU A CD1 1 
ATOM   1467 C  CD2 . LEU A 1 175 ? 0.275   -8.913  31.310  1.00 30.54 ? 176 LEU A CD2 1 
ATOM   1468 N  N   . GLY A 1 176 ? -4.989  -9.136  32.560  1.00 23.59 ? 177 GLY A N   1 
ATOM   1469 C  CA  . GLY A 1 176 ? -6.039  -8.720  33.457  1.00 23.73 ? 177 GLY A CA  1 
ATOM   1470 C  C   . GLY A 1 176 ? -7.087  -7.790  32.876  1.00 26.77 ? 177 GLY A C   1 
ATOM   1471 O  O   . GLY A 1 176 ? -7.948  -7.329  33.623  1.00 28.41 ? 177 GLY A O   1 
ATOM   1472 N  N   . ILE A 1 177 ? -7.059  -7.502  31.578  1.00 21.88 ? 178 ILE A N   1 
ATOM   1473 C  CA  . ILE A 1 177 ? -8.066  -6.619  31.001  1.00 20.80 ? 178 ILE A CA  1 
ATOM   1474 C  C   . ILE A 1 177 ? -9.300  -7.436  30.657  1.00 23.51 ? 178 ILE A C   1 
ATOM   1475 O  O   . ILE A 1 177 ? -9.193  -8.571  30.174  1.00 22.65 ? 178 ILE A O   1 
ATOM   1476 C  CB  . ILE A 1 177 ? -7.521  -5.881  29.764  1.00 20.09 ? 178 ILE A CB  1 
ATOM   1477 C  CG1 . ILE A 1 177 ? -6.215  -5.153  30.105  1.00 21.21 ? 178 ILE A CG1 1 
ATOM   1478 C  CG2 . ILE A 1 177 ? -8.558  -4.874  29.238  1.00 20.33 ? 178 ILE A CG2 1 
ATOM   1479 C  CD1 . ILE A 1 177 ? -5.521  -4.509  28.900  1.00 24.36 ? 178 ILE A CD1 1 
ATOM   1480 N  N   . SER A 1 178 ? -10.475 -6.852  30.902  1.00 23.19 ? 179 SER A N   1 
ATOM   1481 C  CA  . SER A 1 178 ? -11.737 -7.496  30.565  1.00 21.52 ? 179 SER A CA  1 
ATOM   1482 C  C   . SER A 1 178 ? -11.716 -8.003  29.132  1.00 26.18 ? 179 SER A C   1 
ATOM   1483 O  O   . SER A 1 178 ? -11.425 -7.249  28.201  1.00 24.54 ? 179 SER A O   1 
ATOM   1484 C  CB  . SER A 1 178 ? -12.887 -6.505  30.752  1.00 22.59 ? 179 SER A CB  1 
ATOM   1485 O  OG  . SER A 1 178 ? -13.972 -6.868  29.918  1.00 30.65 ? 179 SER A OG  1 
ATOM   1486 N  N   . LYS A 1 179 ? -12.025 -9.294  28.964  1.00 23.18 ? 180 LYS A N   1 
ATOM   1487 C  CA  . LYS A 1 179 ? -12.044 -9.890  27.633  1.00 25.91 ? 180 LYS A CA  1 
ATOM   1488 C  C   . LYS A 1 179 ? -12.939 -9.099  26.696  1.00 22.42 ? 180 LYS A C   1 
ATOM   1489 O  O   . LYS A 1 179 ? -12.558 -8.803  25.555  1.00 20.02 ? 180 LYS A O   1 
ATOM   1490 C  CB  . LYS A 1 179 ? -12.527 -11.339 27.720  1.00 26.47 ? 180 LYS A CB  1 
ATOM   1491 C  CG  . LYS A 1 179 ? -12.980 -11.913 26.407  1.00 34.64 ? 180 LYS A CG  1 
ATOM   1492 C  CD  . LYS A 1 179 ? -12.850 -13.416 26.406  1.00 33.78 ? 180 LYS A CD  1 
ATOM   1493 C  CE  . LYS A 1 179 ? -12.659 -13.957 24.999  1.00 38.22 ? 180 LYS A CE  1 
ATOM   1494 N  NZ  . LYS A 1 179 ? -13.305 -15.296 24.914  1.00 40.10 ? 180 LYS A NZ  1 
ATOM   1495 N  N   . GLU A 1 180 ? -14.112 -8.700  27.179  1.00 21.38 ? 181 GLU A N   1 
ATOM   1496 C  CA  . GLU A 1 180 ? -15.074 -8.058  26.292  1.00 24.17 ? 181 GLU A CA  1 
ATOM   1497 C  C   . GLU A 1 180 ? -14.594 -6.657  25.910  1.00 23.56 ? 181 GLU A C   1 
ATOM   1498 O  O   . GLU A 1 180 ? -14.777 -6.210  24.766  1.00 23.90 ? 181 GLU A O   1 
ATOM   1499 C  CB  . GLU A 1 180 ? -16.452 -8.013  26.954  1.00 31.68 ? 181 GLU A CB  1 
ATOM   1500 C  CG  . GLU A 1 180 ? -17.191 -9.392  27.034  1.00 30.77 ? 181 GLU A CG  1 
ATOM   1501 C  CD  . GLU A 1 180 ? -16.414 -10.461 27.820  1.00 37.39 ? 181 GLU A CD  1 
ATOM   1502 O  OE1 . GLU A 1 180 ? -15.973 -10.154 28.952  1.00 30.50 ? 181 GLU A OE1 1 
ATOM   1503 O  OE2 . GLU A 1 180 ? -16.248 -11.606 27.340  1.00 36.58 ? 181 GLU A OE2 1 
ATOM   1504 N  N   . LEU A 1 181 ? -13.940 -5.966  26.843  1.00 20.24 ? 182 LEU A N   1 
ATOM   1505 C  CA  . LEU A 1 181 ? -13.377 -4.655  26.533  1.00 21.26 ? 182 LEU A CA  1 
ATOM   1506 C  C   . LEU A 1 181 ? -12.291 -4.781  25.465  1.00 21.15 ? 182 LEU A C   1 
ATOM   1507 O  O   . LEU A 1 181 ? -12.256 -4.023  24.468  1.00 22.27 ? 182 LEU A O   1 
ATOM   1508 C  CB  . LEU A 1 181 ? -12.810 -4.048  27.814  1.00 23.00 ? 182 LEU A CB  1 
ATOM   1509 C  CG  . LEU A 1 181 ? -12.410 -2.590  27.788  1.00 22.93 ? 182 LEU A CG  1 
ATOM   1510 C  CD1 . LEU A 1 181 ? -13.661 -1.721  27.608  1.00 24.22 ? 182 LEU A CD1 1 
ATOM   1511 C  CD2 . LEU A 1 181 ? -11.689 -2.262  29.086  1.00 25.67 ? 182 LEU A CD2 1 
ATOM   1512 N  N   . VAL A 1 182 ? -11.413 -5.778  25.644  1.00 19.53 ? 183 VAL A N   1 
ATOM   1513 C  CA  . VAL A 1 182 ? -10.385 -6.057  24.643  1.00 17.61 ? 183 VAL A CA  1 
ATOM   1514 C  C   . VAL A 1 182 ? -11.029 -6.286  23.289  1.00 18.93 ? 183 VAL A C   1 
ATOM   1515 O  O   . VAL A 1 182 ? -10.607 -5.707  22.276  1.00 21.67 ? 183 VAL A O   1 
ATOM   1516 C  CB  . VAL A 1 182 ? -9.531  -7.271  25.068  1.00 20.02 ? 183 VAL A CB  1 
ATOM   1517 C  CG1 . VAL A 1 182 ? -8.610  -7.703  23.921  1.00 23.66 ? 183 VAL A CG1 1 
ATOM   1518 C  CG2 . VAL A 1 182 ? -8.705  -6.959  26.305  1.00 21.99 ? 183 VAL A CG2 1 
ATOM   1519 N  N   . GLU A 1 183 ? -12.094 -7.092  23.259  1.00 21.74 ? 184 GLU A N   1 
ATOM   1520 C  CA  . GLU A 1 183 ? -12.742 -7.406  21.987  1.00 24.01 ? 184 GLU A CA  1 
ATOM   1521 C  C   . GLU A 1 183 ? -13.278 -6.158  21.297  1.00 22.08 ? 184 GLU A C   1 
ATOM   1522 O  O   . GLU A 1 183 ? -13.134 -6.021  20.079  1.00 24.47 ? 184 GLU A O   1 
ATOM   1523 C  CB  . GLU A 1 183 ? -13.867 -8.418  22.199  1.00 25.82 ? 184 GLU A CB  1 
ATOM   1524 C  CG  . GLU A 1 183 ? -13.387 -9.834  22.104  1.00 34.86 ? 184 GLU A CG  1 
ATOM   1525 C  CD  . GLU A 1 183 ? -14.285 -10.844 22.809  1.00 43.89 ? 184 GLU A CD  1 
ATOM   1526 O  OE1 . GLU A 1 183 ? -15.203 -10.431 23.554  1.00 39.31 ? 184 GLU A OE1 1 
ATOM   1527 O  OE2 . GLU A 1 183 ? -14.061 -12.061 22.615  1.00 47.11 ? 184 GLU A OE2 1 
ATOM   1528 N  N   . LYS A 1 184 ? -13.898 -5.239  22.050  1.00 19.86 ? 185 LYS A N   1 
ATOM   1529 C  CA  . LYS A 1 184 ? -14.408 -4.024  21.406  1.00 18.03 ? 185 LYS A CA  1 
ATOM   1530 C  C   . LYS A 1 184 ? -13.286 -3.281  20.681  1.00 21.80 ? 185 LYS A C   1 
ATOM   1531 O  O   . LYS A 1 184 ? -13.424 -2.858  19.516  1.00 23.52 ? 185 LYS A O   1 
ATOM   1532 C  CB  . LYS A 1 184 ? -15.058 -3.103  22.435  1.00 23.05 ? 185 LYS A CB  1 
ATOM   1533 C  CG  . LYS A 1 184 ? -15.642 -1.832  21.797  1.00 26.18 ? 185 LYS A CG  1 
ATOM   1534 C  CD  . LYS A 1 184 ? -16.289 -0.929  22.830  1.00 32.62 ? 185 LYS A CD  1 
ATOM   1535 C  CE  . LYS A 1 184 ? -15.440 0.260   23.135  1.00 37.82 ? 185 LYS A CE  1 
ATOM   1536 N  NZ  . LYS A 1 184 ? -16.269 1.508   23.087  1.00 36.74 ? 185 LYS A NZ  1 
ATOM   1537 N  N   . HIS A 1 185 ? -12.145 -3.133  21.350  1.00 20.69 ? 186 HIS A N   1 
ATOM   1538 C  CA  . HIS A 1 185 ? -11.081 -2.332  20.737  1.00 19.05 ? 186 HIS A CA  1 
ATOM   1539 C  C   . HIS A 1 185 ? -10.367 -3.070  19.608  1.00 20.11 ? 186 HIS A C   1 
ATOM   1540 O  O   . HIS A 1 185 ? -10.039 -2.464  18.573  1.00 21.34 ? 186 HIS A O   1 
ATOM   1541 C  CB  . HIS A 1 185 ? -10.133 -1.891  21.833  1.00 18.16 ? 186 HIS A CB  1 
ATOM   1542 C  CG  . HIS A 1 185 ? -10.811 -0.990  22.796  1.00 23.31 ? 186 HIS A CG  1 
ATOM   1543 N  ND1 . HIS A 1 185 ? -11.544 -1.472  23.857  1.00 22.29 ? 186 HIS A ND1 1 
ATOM   1544 C  CD2 . HIS A 1 185 ? -10.979 0.347   22.791  1.00 22.73 ? 186 HIS A CD2 1 
ATOM   1545 C  CE1 . HIS A 1 185 ? -12.093 -0.461  24.501  1.00 20.57 ? 186 HIS A CE1 1 
ATOM   1546 N  NE2 . HIS A 1 185 ? -11.756 0.650   23.873  1.00 26.67 ? 186 HIS A NE2 1 
ATOM   1547 N  N   . LEU A 1 186 ? -10.138 -4.373  19.768  1.00 21.82 ? 187 LEU A N   1 
ATOM   1548 C  CA  . LEU A 1 186 ? -9.490  -5.114  18.690  1.00 20.84 ? 187 LEU A CA  1 
ATOM   1549 C  C   . LEU A 1 186 ? -10.402 -5.218  17.466  1.00 23.92 ? 187 LEU A C   1 
ATOM   1550 O  O   . LEU A 1 186 ? -9.911  -5.260  16.333  1.00 21.15 ? 187 LEU A O   1 
ATOM   1551 C  CB  . LEU A 1 186 ? -9.048  -6.489  19.186  1.00 24.41 ? 187 LEU A CB  1 
ATOM   1552 C  CG  . LEU A 1 186 ? -7.859  -6.496  20.169  1.00 31.04 ? 187 LEU A CG  1 
ATOM   1553 C  CD1 . LEU A 1 186 ? -7.011  -7.764  20.105  1.00 25.34 ? 187 LEU A CD1 1 
ATOM   1554 C  CD2 . LEU A 1 186 ? -6.987  -5.262  20.012  1.00 33.79 ? 187 LEU A CD2 1 
ATOM   1555 N  N   . GLU A 1 187 ? -11.725 -5.237  17.672  1.00 23.42 ? 188 GLU A N   1 
ATOM   1556 C  CA  . GLU A 1 187 ? -12.645 -5.192  16.538  1.00 27.03 ? 188 GLU A CA  1 
ATOM   1557 C  C   . GLU A 1 187 ? -12.521 -3.872  15.794  1.00 26.74 ? 188 GLU A C   1 
ATOM   1558 O  O   . GLU A 1 187 ? -12.564 -3.825  14.549  1.00 26.13 ? 188 GLU A O   1 
ATOM   1559 C  CB  . GLU A 1 187 ? -14.075 -5.409  17.029  1.00 31.93 ? 188 GLU A CB  1 
ATOM   1560 C  CG  . GLU A 1 187 ? -14.627 -6.787  16.746  1.00 38.10 ? 188 GLU A CG  1 
ATOM   1561 C  CD  . GLU A 1 187 ? -14.562 -7.131  15.270  1.00 39.16 ? 188 GLU A CD  1 
ATOM   1562 O  OE1 . GLU A 1 187 ? -15.057 -6.318  14.459  1.00 52.71 ? 188 GLU A OE1 1 
ATOM   1563 O  OE2 . GLU A 1 187 ? -14.015 -8.195  14.912  1.00 47.00 ? 188 GLU A OE2 1 
ATOM   1564 N  N   . ARG A 1 188 ? -12.359 -2.782  16.539  1.00 25.74 ? 189 ARG A N   1 
ATOM   1565 C  CA  . ARG A 1 188 ? -12.173 -1.502  15.865  1.00 25.03 ? 189 ARG A CA  1 
ATOM   1566 C  C   . ARG A 1 188 ? -10.874 -1.494  15.048  1.00 22.69 ? 189 ARG A C   1 
ATOM   1567 O  O   . ARG A 1 188 ? -10.836 -0.993  13.914  1.00 24.23 ? 189 ARG A O   1 
ATOM   1568 C  CB  . ARG A 1 188 ? -12.229 -0.393  16.913  1.00 28.73 ? 189 ARG A CB  1 
ATOM   1569 C  CG  . ARG A 1 188 ? -13.623 0.209   16.972  1.00 36.38 ? 189 ARG A CG  1 
ATOM   1570 C  CD  . ARG A 1 188 ? -13.606 1.701   17.022  1.00 39.43 ? 189 ARG A CD  1 
ATOM   1571 N  NE  . ARG A 1 188 ? -12.754 2.217   18.089  1.00 37.25 ? 189 ARG A NE  1 
ATOM   1572 C  CZ  . ARG A 1 188 ? -13.214 2.633   19.260  1.00 36.40 ? 189 ARG A CZ  1 
ATOM   1573 N  NH1 . ARG A 1 188 ? -14.512 2.639   19.529  1.00 43.17 ? 189 ARG A NH1 1 
ATOM   1574 N  NH2 . ARG A 1 188 ? -12.354 3.047   20.186  1.00 33.03 ? 189 ARG A NH2 1 
ATOM   1575 N  N   . ILE A 1 189 ? -9.801  -2.082  15.590  1.00 18.37 ? 190 ILE A N   1 
ATOM   1576 C  CA  . ILE A 1 189 ? -8.557  -2.163  14.821  1.00 21.53 ? 190 ILE A CA  1 
ATOM   1577 C  C   . ILE A 1 189 ? -8.755  -2.998  13.554  1.00 24.41 ? 190 ILE A C   1 
ATOM   1578 O  O   . ILE A 1 189 ? -8.273  -2.636  12.465  1.00 23.30 ? 190 ILE A O   1 
ATOM   1579 C  CB  . ILE A 1 189 ? -7.423  -2.715  15.707  1.00 20.35 ? 190 ILE A CB  1 
ATOM   1580 C  CG1 . ILE A 1 189 ? -7.029  -1.667  16.753  1.00 23.50 ? 190 ILE A CG1 1 
ATOM   1581 C  CG2 . ILE A 1 189 ? -6.217  -3.169  14.873  1.00 21.96 ? 190 ILE A CG2 1 
ATOM   1582 C  CD1 . ILE A 1 189 ? -6.053  -2.188  17.772  1.00 23.90 ? 190 ILE A CD1 1 
ATOM   1583 N  N   . LYS A 1 190 ? -9.460  -4.128  13.675  1.00 21.69 ? 191 LYS A N   1 
ATOM   1584 C  CA  . LYS A 1 190 ? -9.730  -4.971  12.506  1.00 23.57 ? 191 LYS A CA  1 
ATOM   1585 C  C   . LYS A 1 190 ? -10.484 -4.206  11.426  1.00 21.16 ? 191 LYS A C   1 
ATOM   1586 O  O   . LYS A 1 190 ? -10.129 -4.267  10.237  1.00 24.97 ? 191 LYS A O   1 
ATOM   1587 C  CB  . LYS A 1 190 ? -10.525 -6.209  12.919  1.00 22.85 ? 191 LYS A CB  1 
ATOM   1588 C  CG  . LYS A 1 190 ? -10.694 -7.196  11.781  1.00 26.60 ? 191 LYS A CG  1 
ATOM   1589 C  CD  . LYS A 1 190 ? -11.426 -8.453  12.226  1.00 31.90 ? 191 LYS A CD  1 
ATOM   1590 C  CE  . LYS A 1 190 ? -11.904 -9.216  10.999  1.00 37.04 ? 191 LYS A CE  1 
ATOM   1591 N  NZ  . LYS A 1 190 ? -12.765 -10.364 11.385  1.00 45.93 ? 191 LYS A NZ  1 
ATOM   1592 N  N   . LYS A 1 191 ? -11.519 -3.462  11.820  1.00 23.55 ? 192 LYS A N   1 
ATOM   1593 C  CA  . LYS A 1 191 ? -12.300 -2.715  10.834  1.00 24.68 ? 192 LYS A CA  1 
ATOM   1594 C  C   . LYS A 1 191 ? -11.456 -1.639  10.152  1.00 25.26 ? 192 LYS A C   1 
ATOM   1595 O  O   . LYS A 1 191 ? -11.536 -1.451  8.933   1.00 26.75 ? 192 LYS A O   1 
ATOM   1596 C  CB  . LYS A 1 191 ? -13.528 -2.095  11.501  1.00 27.46 ? 192 LYS A CB  1 
ATOM   1597 C  CG  . LYS A 1 191 ? -14.196 -0.986  10.690  1.00 34.26 ? 192 LYS A CG  1 
ATOM   1598 C  CD  . LYS A 1 191 ? -15.369 -0.387  11.449  1.00 31.87 ? 192 LYS A CD  1 
ATOM   1599 C  CE  . LYS A 1 191 ? -16.009 0.743   10.671  1.00 39.21 ? 192 LYS A CE  1 
ATOM   1600 N  NZ  . LYS A 1 191 ? -17.316 1.153   11.248  1.00 47.75 ? 192 LYS A NZ  1 
ATOM   1601 N  N   . ALA A 1 192 ? -10.628 -0.922  10.914  1.00 20.56 ? 193 ALA A N   1 
ATOM   1602 C  CA  . ALA A 1 192 ? -9.774  0.083   10.278  1.00 22.85 ? 193 ALA A CA  1 
ATOM   1603 C  C   . ALA A 1 192 ? -8.798  -0.557  9.298   1.00 22.20 ? 193 ALA A C   1 
ATOM   1604 O  O   . ALA A 1 192 ? -8.559  -0.032  8.201   1.00 22.97 ? 193 ALA A O   1 
ATOM   1605 C  CB  . ALA A 1 192 ? -9.012  0.859   11.345  1.00 24.44 ? 193 ALA A CB  1 
ATOM   1606 N  N   . ALA A 1 193 ? -8.190  -1.670  9.698   1.00 19.83 ? 194 ALA A N   1 
ATOM   1607 C  CA  . ALA A 1 193 ? -7.212  -2.329  8.850   1.00 20.73 ? 194 ALA A CA  1 
ATOM   1608 C  C   . ALA A 1 193 ? -7.861  -2.823  7.574   1.00 23.90 ? 194 ALA A C   1 
ATOM   1609 O  O   . ALA A 1 193 ? -7.283  -2.705  6.493   1.00 30.47 ? 194 ALA A O   1 
ATOM   1610 C  CB  . ALA A 1 193 ? -6.572  -3.493  9.601   1.00 23.22 ? 194 ALA A CB  1 
ATOM   1611 N  N   . GLU A 1 194 ? -9.070  -3.377  7.686   1.00 25.65 ? 195 GLU A N   1 
ATOM   1612 C  CA  . GLU A 1 194 ? -9.799  -3.785  6.488   1.00 28.68 ? 195 GLU A CA  1 
ATOM   1613 C  C   . GLU A 1 194 ? -10.099 -2.586  5.592   1.00 28.22 ? 195 GLU A C   1 
ATOM   1614 O  O   . GLU A 1 194 ? -9.984  -2.679  4.361   1.00 31.67 ? 195 GLU A O   1 
ATOM   1615 C  CB  . GLU A 1 194 ? -11.080 -4.516  6.887   1.00 27.82 ? 195 GLU A CB  1 
ATOM   1616 N  N   . LEU A 1 195 ? -10.444 -1.436  6.185   1.00 27.58 ? 196 LEU A N   1 
ATOM   1617 C  CA  . LEU A 1 195 ? -10.682 -0.237  5.379   1.00 27.89 ? 196 LEU A CA  1 
ATOM   1618 C  C   . LEU A 1 195 ? -9.436  0.178   4.601   1.00 29.21 ? 196 LEU A C   1 
ATOM   1619 O  O   . LEU A 1 195 ? -9.511  0.483   3.405   1.00 30.37 ? 196 LEU A O   1 
ATOM   1620 C  CB  . LEU A 1 195 ? -11.159 0.926   6.257   1.00 28.10 ? 196 LEU A CB  1 
ATOM   1621 C  CG  . LEU A 1 195 ? -12.594 0.949   6.777   1.00 29.88 ? 196 LEU A CG  1 
ATOM   1622 C  CD1 . LEU A 1 195 ? -12.792 2.070   7.768   1.00 31.92 ? 196 LEU A CD1 1 
ATOM   1623 C  CD2 . LEU A 1 195 ? -13.552 1.103   5.601   1.00 34.43 ? 196 LEU A CD2 1 
ATOM   1624 N  N   . VAL A 1 196 ? -8.280  0.223   5.266   1.00 24.34 ? 197 VAL A N   1 
ATOM   1625 C  CA  . VAL A 1 196 ? -7.061  0.621   4.561   1.00 21.71 ? 197 VAL A CA  1 
ATOM   1626 C  C   . VAL A 1 196 ? -6.671  -0.431  3.528   1.00 26.81 ? 197 VAL A C   1 
ATOM   1627 O  O   . VAL A 1 196 ? -6.163  -0.099  2.450   1.00 31.73 ? 197 VAL A O   1 
ATOM   1628 C  CB  . VAL A 1 196 ? -5.903  0.893   5.540   1.00 23.26 ? 197 VAL A CB  1 
ATOM   1629 C  CG1 . VAL A 1 196 ? -4.680  1.405   4.762   1.00 23.03 ? 197 VAL A CG1 1 
ATOM   1630 C  CG2 . VAL A 1 196 ? -6.311  1.913   6.603   1.00 23.75 ? 197 VAL A CG2 1 
ATOM   1631 N  N   . LEU A 1 197 ? -6.877  -1.710  3.845   1.00 27.37 ? 198 LEU A N   1 
ATOM   1632 C  CA  . LEU A 1 197 ? -6.604  -2.769  2.884   1.00 29.29 ? 198 LEU A CA  1 
ATOM   1633 C  C   . LEU A 1 197 ? -7.492  -2.611  1.656   1.00 33.89 ? 198 LEU A C   1 
ATOM   1634 O  O   . LEU A 1 197 ? -7.105  -3.010  0.551   1.00 44.37 ? 198 LEU A O   1 
ATOM   1635 C  CB  . LEU A 1 197 ? -6.830  -4.129  3.546   1.00 28.58 ? 198 LEU A CB  1 
ATOM   1636 C  CG  . LEU A 1 197 ? -5.633  -4.787  4.242   1.00 31.10 ? 198 LEU A CG  1 
ATOM   1637 C  CD1 . LEU A 1 197 ? -6.085  -5.940  5.129   1.00 32.75 ? 198 LEU A CD1 1 
ATOM   1638 C  CD2 . LEU A 1 197 ? -4.575  -5.244  3.257   1.00 35.63 ? 198 LEU A CD2 1 
ATOM   1639 N  N   . SER A 1 198 ? -8.677  -2.015  1.833   1.00 34.11 ? 199 SER A N   1 
ATOM   1640 C  CA  . SER A 1 198 ? -9.582  -1.768  0.712   1.00 40.36 ? 199 SER A CA  1 
ATOM   1641 C  C   . SER A 1 198 ? -8.962  -0.819  -0.308  1.00 42.34 ? 199 SER A C   1 
ATOM   1642 O  O   . SER A 1 198 ? -8.984  -1.087  -1.515  1.00 46.35 ? 199 SER A O   1 
ATOM   1643 C  CB  . SER A 1 198 ? -10.908 -1.207  1.229   1.00 36.89 ? 199 SER A CB  1 
ATOM   1644 O  OG  . SER A 1 198 ? -11.744 -2.242  1.703   1.00 48.13 ? 199 SER A OG  1 
ATOM   1645 N  N   . MET A 1 199 ? -8.411  0.302   0.152   1.00 39.88 ? 200 MET A N   1 
ATOM   1646 C  CA  . MET A 1 199 ? -7.671  1.165   -0.755  1.00 42.68 ? 200 MET A CA  1 
ATOM   1647 C  C   . MET A 1 199 ? -6.453  0.421   -1.284  1.00 46.04 ? 200 MET A C   1 
ATOM   1648 O  O   . MET A 1 199 ? -5.859  -0.412  -0.597  1.00 51.16 ? 200 MET A O   1 
ATOM   1649 C  CB  . MET A 1 199 ? -7.220  2.447   -0.063  1.00 42.36 ? 200 MET A CB  1 
ATOM   1650 C  CG  . MET A 1 199 ? -8.322  3.271   0.532   1.00 40.79 ? 200 MET A CG  1 
ATOM   1651 S  SD  . MET A 1 199 ? -7.684  4.090   1.997   1.00 56.03 ? 200 MET A SD  1 
ATOM   1652 C  CE  . MET A 1 199 ? -7.930  5.803   1.510   1.00 36.74 ? 200 MET A CE  1 
ATOM   1653 N  N   . GLY A 1 200 ? -6.081  0.725   -2.524  1.00 46.38 ? 201 GLY A N   1 
ATOM   1654 C  CA  . GLY A 1 200 ? -5.000  0.048   -3.206  1.00 46.80 ? 201 GLY A CA  1 
ATOM   1655 C  C   . GLY A 1 200 ? -5.482  -0.863  -4.313  1.00 45.58 ? 201 GLY A C   1 
ATOM   1656 O  O   . GLY A 1 200 ? -4.745  -1.096  -5.276  1.00 52.77 ? 201 GLY A O   1 
ATOM   1657 N  N   . SER A 1 201 ? -6.701  -1.387  -4.190  1.00 44.33 ? 202 SER A N   1 
ATOM   1658 C  CA  . SER A 1 201 ? -7.394  -1.870  -5.374  1.00 45.94 ? 202 SER A CA  1 
ATOM   1659 C  C   . SER A 1 201 ? -7.706  -0.723  -6.323  1.00 45.20 ? 202 SER A C   1 
ATOM   1660 O  O   . SER A 1 201 ? -7.937  -0.962  -7.514  1.00 45.19 ? 202 SER A O   1 
ATOM   1661 C  CB  . SER A 1 201 ? -8.678  -2.600  -4.977  1.00 44.35 ? 202 SER A CB  1 
ATOM   1662 N  N   . LEU A 1 202 ? -7.689  0.520   -5.821  1.00 39.93 ? 203 LEU A N   1 
ATOM   1663 C  CA  . LEU A 1 202 ? -8.034  1.705   -6.594  1.00 40.96 ? 203 LEU A CA  1 
ATOM   1664 C  C   . LEU A 1 202 ? -6.923  2.745   -6.679  1.00 41.42 ? 203 LEU A C   1 
ATOM   1665 O  O   . LEU A 1 202 ? -7.152  3.820   -7.247  1.00 40.19 ? 203 LEU A O   1 
ATOM   1666 C  CB  . LEU A 1 202 ? -9.297  2.367   -6.021  1.00 49.60 ? 203 LEU A CB  1 
ATOM   1667 N  N   . GLU A 1 203 ? -5.731  2.473   -6.147  1.00 36.46 ? 204 GLU A N   1 
ATOM   1668 C  CA  . GLU A 1 203 ? -4.601  3.329   -6.471  1.00 38.50 ? 204 GLU A CA  1 
ATOM   1669 C  C   . GLU A 1 203 ? -4.231  3.138   -7.943  1.00 31.89 ? 204 GLU A C   1 
ATOM   1670 O  O   . GLU A 1 203 ? -4.683  2.197   -8.593  1.00 31.60 ? 204 GLU A O   1 
ATOM   1671 C  CB  . GLU A 1 203 ? -3.411  3.026   -5.564  1.00 38.47 ? 204 GLU A CB  1 
ATOM   1672 N  N   . SER A 1 204 ? -3.384  4.040   -8.462  1.00 33.86 ? 205 SER A N   1 
ATOM   1673 C  CA  . SER A 1 204 ? -3.254  4.198   -9.913  1.00 31.42 ? 205 SER A CA  1 
ATOM   1674 C  C   . SER A 1 204 ? -2.774  2.917   -10.598 1.00 29.00 ? 205 SER A C   1 
ATOM   1675 O  O   . SER A 1 204 ? -3.297  2.543   -11.655 1.00 30.20 ? 205 SER A O   1 
ATOM   1676 C  CB  . SER A 1 204 ? -2.344  5.393   -10.236 1.00 31.57 ? 205 SER A CB  1 
ATOM   1677 O  OG  . SER A 1 204 ? -0.969  5.131   -10.006 1.00 34.41 ? 205 SER A OG  1 
ATOM   1678 N  N   . SER A 1 205 ? -1.798  2.219   -10.011 1.00 25.10 ? 206 SER A N   1 
ATOM   1679 C  CA  . SER A 1 205 ? -1.368  0.946   -10.587 1.00 23.38 ? 206 SER A CA  1 
ATOM   1680 C  C   . SER A 1 205 ? -2.455  -0.119  -10.487 1.00 26.41 ? 206 SER A C   1 
ATOM   1681 O  O   . SER A 1 205 ? -2.611  -0.941  -11.400 1.00 30.59 ? 206 SER A O   1 
ATOM   1682 C  CB  . SER A 1 205 ? -0.087  0.457   -9.911  1.00 32.13 ? 206 SER A CB  1 
ATOM   1683 O  OG  . SER A 1 205 ? 1.040   1.147   -10.425 1.00 34.17 ? 206 SER A OG  1 
ATOM   1684 N  N   . GLY A 1 206 ? -3.198  -0.145  -9.374  1.00 28.24 ? 207 GLY A N   1 
ATOM   1685 C  CA  . GLY A 1 206 ? -4.300  -1.088  -9.269  1.00 31.36 ? 207 GLY A CA  1 
ATOM   1686 C  C   . GLY A 1 206 ? -5.346  -0.847  -10.341 1.00 29.28 ? 207 GLY A C   1 
ATOM   1687 O  O   . GLY A 1 206 ? -5.879  -1.791  -10.943 1.00 30.90 ? 207 GLY A O   1 
ATOM   1688 N  N   . LEU A 1 207 ? -5.638  0.425   -10.605 1.00 32.83 ? 208 LEU A N   1 
ATOM   1689 C  CA  . LEU A 1 207 ? -6.565  0.764   -11.672 1.00 29.55 ? 208 LEU A CA  1 
ATOM   1690 C  C   . LEU A 1 207 ? -6.018  0.327   -13.027 1.00 32.62 ? 208 LEU A C   1 
ATOM   1691 O  O   . LEU A 1 207 ? -6.764  -0.200  -13.859 1.00 24.99 ? 208 LEU A O   1 
ATOM   1692 C  CB  . LEU A 1 207 ? -6.846  2.265   -11.640 1.00 27.85 ? 208 LEU A CB  1 
ATOM   1693 C  CG  . LEU A 1 207 ? -7.681  2.695   -10.428 1.00 32.56 ? 208 LEU A CG  1 
ATOM   1694 C  CD1 . LEU A 1 207 ? -8.255  4.079   -10.615 1.00 30.50 ? 208 LEU A CD1 1 
ATOM   1695 C  CD2 . LEU A 1 207 ? -8.783  1.671   -10.141 1.00 36.85 ? 208 LEU A CD2 1 
ATOM   1696 N  N   . GLU A 1 208 ? -4.715  0.520   -13.263 1.00 27.66 ? 209 GLU A N   1 
ATOM   1697 C  CA  . GLU A 1 208 ? -4.127  0.046   -14.517 1.00 26.43 ? 209 GLU A CA  1 
ATOM   1698 C  C   . GLU A 1 208 ? -4.302  -1.466  -14.657 1.00 29.00 ? 209 GLU A C   1 
ATOM   1699 O  O   . GLU A 1 208 ? -4.537  -1.974  -15.761 1.00 24.99 ? 209 GLU A O   1 
ATOM   1700 C  CB  . GLU A 1 208 ? -2.638  0.434   -14.599 1.00 24.24 ? 209 GLU A CB  1 
ATOM   1701 C  CG  . GLU A 1 208 ? -2.374  1.956   -14.585 1.00 27.31 ? 209 GLU A CG  1 
ATOM   1702 C  CD  . GLU A 1 208 ? -1.104  2.419   -15.317 1.00 34.85 ? 209 GLU A CD  1 
ATOM   1703 O  OE1 . GLU A 1 208 ? -0.442  1.608   -15.982 1.00 25.84 ? 209 GLU A OE1 1 
ATOM   1704 O  OE2 . GLU A 1 208 ? -0.752  3.619   -15.195 1.00 36.36 ? 209 GLU A OE2 1 
ATOM   1705 N  N   . VAL A 1 209 ? -4.183  -2.203  -13.547 1.00 25.89 ? 210 VAL A N   1 
ATOM   1706 C  CA  . VAL A 1 209 ? -4.392  -3.651  -13.578 1.00 27.19 ? 210 VAL A CA  1 
ATOM   1707 C  C   . VAL A 1 209 ? -5.816  -3.973  -14.024 1.00 31.50 ? 210 VAL A C   1 
ATOM   1708 O  O   . VAL A 1 209 ? -6.038  -4.809  -14.910 1.00 30.04 ? 210 VAL A O   1 
ATOM   1709 C  CB  . VAL A 1 209 ? -4.087  -4.270  -12.199 1.00 32.65 ? 210 VAL A CB  1 
ATOM   1710 C  CG1 . VAL A 1 209 ? -4.581  -5.713  -12.136 1.00 31.73 ? 210 VAL A CG1 1 
ATOM   1711 C  CG2 . VAL A 1 209 ? -2.580  -4.214  -11.881 1.00 28.31 ? 210 VAL A CG2 1 
ATOM   1712 N  N   . LEU A 1 210 ? -6.803  -3.292  -13.429 1.00 26.98 ? 211 LEU A N   1 
ATOM   1713 C  CA  . LEU A 1 210 ? -8.208  -3.609  -13.727 1.00 29.53 ? 211 LEU A CA  1 
ATOM   1714 C  C   . LEU A 1 210 ? -8.628  -3.186  -15.135 1.00 26.60 ? 211 LEU A C   1 
ATOM   1715 O  O   . LEU A 1 210 ? -9.458  -3.852  -15.770 1.00 27.64 ? 211 LEU A O   1 
ATOM   1716 C  CB  . LEU A 1 210 ? -9.129  -2.956  -12.693 1.00 33.53 ? 211 LEU A CB  1 
ATOM   1717 C  CG  . LEU A 1 210 ? -8.852  -3.273  -11.233 1.00 32.78 ? 211 LEU A CG  1 
ATOM   1718 C  CD1 . LEU A 1 210 ? -9.591  -2.309  -10.297 1.00 33.29 ? 211 LEU A CD1 1 
ATOM   1719 C  CD2 . LEU A 1 210 ? -9.286  -4.699  -10.988 1.00 35.50 ? 211 LEU A CD2 1 
ATOM   1720 N  N   . PHE A 1 211 ? -8.103  -2.071  -15.628 1.00 26.02 ? 212 PHE A N   1 
ATOM   1721 C  CA  . PHE A 1 211 ? -8.591  -1.482  -16.874 1.00 23.03 ? 212 PHE A CA  1 
ATOM   1722 C  C   . PHE A 1 211 ? -7.753  -1.858  -18.091 1.00 34.17 ? 212 PHE A C   1 
ATOM   1723 O  O   . PHE A 1 211 ? -8.279  -1.864  -19.207 1.00 37.33 ? 212 PHE A O   1 
ATOM   1724 C  CB  . PHE A 1 211 ? -8.650  0.047   -16.751 1.00 30.05 ? 212 PHE A CB  1 
ATOM   1725 C  CG  . PHE A 1 211 ? -9.895  0.559   -16.064 1.00 23.74 ? 212 PHE A CG  1 
ATOM   1726 C  CD1 . PHE A 1 211 ? -9.949  0.636   -14.677 1.00 25.88 ? 212 PHE A CD1 1 
ATOM   1727 C  CD2 . PHE A 1 211 ? -10.989 0.984   -16.793 1.00 22.66 ? 212 PHE A CD2 1 
ATOM   1728 C  CE1 . PHE A 1 211 ? -11.083 1.103   -14.021 1.00 26.57 ? 212 PHE A CE1 1 
ATOM   1729 C  CE2 . PHE A 1 211 ? -12.128 1.456   -16.148 1.00 24.90 ? 212 PHE A CE2 1 
ATOM   1730 C  CZ  . PHE A 1 211 ? -12.175 1.516   -14.754 1.00 21.85 ? 212 PHE A CZ  1 
ATOM   1731 N  N   . GLN A 1 212 ? -6.478  -2.195  -17.895 1.00 32.82 ? 213 GLN A N   1 
ATOM   1732 C  CA  . GLN A 1 212 ? -5.520  -2.460  -18.978 1.00 34.39 ? 213 GLN A CA  1 
ATOM   1733 C  C   . GLN A 1 212 ? -5.642  -1.463  -20.134 1.00 36.59 ? 213 GLN A C   1 
ATOM   1734 O  O   . GLN A 1 212 ? -5.339  -1.793  -21.291 1.00 37.46 ? 213 GLN A O   1 
ATOM   1735 C  CB  . GLN A 1 212 ? -5.666  -3.887  -19.515 1.00 32.43 ? 213 GLN A CB  1 
ATOM   1736 C  CG  . GLN A 1 212 ? -5.661  -4.968  -18.426 1.00 32.43 ? 213 GLN A CG  1 
ATOM   1737 C  CD  . GLN A 1 212 ? -4.264  -5.488  -18.127 1.00 34.02 ? 213 GLN A CD  1 
ATOM   1738 O  OE1 . GLN A 1 212 ? -3.817  -5.446  -16.980 1.00 35.55 ? 213 GLN A OE1 1 
ATOM   1739 N  NE2 . GLN A 1 212 ? -3.540  -5.895  -19.162 1.00 33.55 ? 213 GLN A NE2 1 
HETATM 1740 ZN ZN  . ZN  B 2 .   ? -0.578  17.018  0.898   1.00 31.33 ? 301 ZN  A ZN  1 
HETATM 1741 ZN ZN  . ZN  C 2 .   ? -12.744 2.486   24.515  1.00 24.02 ? 302 ZN  A ZN  1 
HETATM 1742 ZN ZN  . ZN  D 2 .   ? 0.511   3.480   -2.120  1.00 45.08 ? 303 ZN  A ZN  1 
HETATM 1743 ZN ZN  . ZN  E 2 .   ? -8.025  -17.777 27.362  1.00 42.11 ? 304 ZN  A ZN  1 
HETATM 1744 ZN ZN  . ZN  F 2 .   ? 3.441   20.891  15.291  1.00 36.97 ? 305 ZN  A ZN  1 
HETATM 1745 ZN ZN  . ZN  G 2 .   ? 12.961  0.279   18.715  1.00 67.92 ? 306 ZN  A ZN  1 
HETATM 1746 ZN ZN  . ZN  H 2 .   ? 15.531  2.777   -2.484  1.00 52.76 ? 307 ZN  A ZN  1 
HETATM 1747 O  O   . HOH I 3 .   ? -4.448  -0.555  21.797  1.00 42.34 ? 401 HOH A O   1 
HETATM 1748 O  O   . HOH I 3 .   ? -10.795 3.358   21.351  1.00 37.15 ? 402 HOH A O   1 
HETATM 1749 O  O   . HOH I 3 .   ? 6.863   16.619  27.392  1.00 34.73 ? 403 HOH A O   1 
HETATM 1750 O  O   . HOH I 3 .   ? -15.542 3.532   15.617  1.00 41.24 ? 404 HOH A O   1 
HETATM 1751 O  O   . HOH I 3 .   ? 12.647  -16.743 13.857  1.00 48.14 ? 405 HOH A O   1 
HETATM 1752 O  O   . HOH I 3 .   ? 5.556   -11.605 35.746  1.00 46.71 ? 406 HOH A O   1 
HETATM 1753 O  O   . HOH I 3 .   ? 1.066   -16.582 20.491  1.00 40.28 ? 407 HOH A O   1 
HETATM 1754 O  O   . HOH I 3 .   ? 0.720   1.685   37.790  1.00 29.20 ? 408 HOH A O   1 
HETATM 1755 O  O   . HOH I 3 .   ? -9.130  13.715  15.299  1.00 43.74 ? 409 HOH A O   1 
HETATM 1756 O  O   . HOH I 3 .   ? -9.189  -15.375 24.291  1.00 41.76 ? 410 HOH A O   1 
HETATM 1757 O  O   . HOH I 3 .   ? 1.782   -10.644 26.181  1.00 41.88 ? 411 HOH A O   1 
HETATM 1758 O  O   . HOH I 3 .   ? 10.731  -16.028 22.324  1.00 51.68 ? 412 HOH A O   1 
HETATM 1759 O  O   . HOH I 3 .   ? -13.355 16.643  16.940  1.00 44.83 ? 413 HOH A O   1 
HETATM 1760 O  O   . HOH I 3 .   ? -13.426 -10.235 15.245  1.00 54.54 ? 414 HOH A O   1 
HETATM 1761 O  O   . HOH I 3 .   ? 7.305   -6.504  16.934  1.00 34.50 ? 415 HOH A O   1 
HETATM 1762 O  O   . HOH I 3 .   ? 16.029  -11.593 29.974  1.00 46.48 ? 416 HOH A O   1 
HETATM 1763 O  O   . HOH I 3 .   ? -18.776 2.648   18.293  1.00 37.41 ? 417 HOH A O   1 
HETATM 1764 O  O   . HOH I 3 .   ? -12.633 4.482   16.984  1.00 35.54 ? 418 HOH A O   1 
HETATM 1765 O  O   . HOH I 3 .   ? -8.161  6.070   36.635  1.00 45.33 ? 419 HOH A O   1 
HETATM 1766 O  O   . HOH I 3 .   ? 1.216   -8.587  17.880  1.00 36.32 ? 420 HOH A O   1 
HETATM 1767 O  O   . HOH I 3 .   ? 14.510  0.131   -2.153  1.00 50.01 ? 421 HOH A O   1 
HETATM 1768 O  O   . HOH I 3 .   ? 15.188  3.301   -0.319  1.00 54.27 ? 422 HOH A O   1 
HETATM 1769 O  O   . HOH I 3 .   ? 17.545  4.429   24.534  1.00 32.34 ? 423 HOH A O   1 
HETATM 1770 O  O   . HOH I 3 .   ? -22.297 11.118  10.283  1.00 44.59 ? 424 HOH A O   1 
HETATM 1771 O  O   . HOH I 3 .   ? -1.726  5.532   -14.206 1.00 38.69 ? 425 HOH A O   1 
HETATM 1772 O  O   . HOH I 3 .   ? -20.357 4.969   -1.859  1.00 48.14 ? 426 HOH A O   1 
HETATM 1773 O  O   . HOH I 3 .   ? -3.628  -6.040  -21.534 1.00 41.05 ? 427 HOH A O   1 
HETATM 1774 O  O   . HOH I 3 .   ? 3.330   -8.669  0.092   1.00 37.70 ? 428 HOH A O   1 
HETATM 1775 O  O   . HOH I 3 .   ? -4.536  -19.821 11.627  1.00 45.27 ? 429 HOH A O   1 
HETATM 1776 O  O   . HOH I 3 .   ? 13.001  9.616   13.672  1.00 48.12 ? 430 HOH A O   1 
HETATM 1777 O  O   . HOH I 3 .   ? 10.057  -11.197 7.292   1.00 41.99 ? 431 HOH A O   1 
HETATM 1778 O  O   . HOH I 3 .   ? -17.700 3.036   -0.916  1.00 51.64 ? 432 HOH A O   1 
HETATM 1779 O  O   . HOH I 3 .   ? 12.928  3.287   22.449  1.00 33.15 ? 433 HOH A O   1 
HETATM 1780 O  O   . HOH I 3 .   ? 11.360  -6.076  18.676  1.00 38.67 ? 434 HOH A O   1 
HETATM 1781 O  O   . HOH I 3 .   ? -3.318  10.371  25.623  1.00 38.46 ? 435 HOH A O   1 
HETATM 1782 O  O   . HOH I 3 .   ? 1.105   -15.418 22.989  1.00 40.09 ? 436 HOH A O   1 
HETATM 1783 O  O   . HOH I 3 .   ? 14.946  -3.415  32.437  1.00 41.60 ? 437 HOH A O   1 
HETATM 1784 O  O   . HOH I 3 .   ? -2.590  0.020   -5.973  1.00 48.45 ? 438 HOH A O   1 
HETATM 1785 O  O   . HOH I 3 .   ? 11.849  -1.300  -4.482  1.00 24.94 ? 439 HOH A O   1 
HETATM 1786 O  O   . HOH I 3 .   ? 12.189  -15.751 38.030  1.00 34.32 ? 440 HOH A O   1 
HETATM 1787 O  O   . HOH I 3 .   ? -5.014  -2.096  20.751  1.00 30.31 ? 441 HOH A O   1 
HETATM 1788 O  O   . HOH I 3 .   ? 17.543  -8.993  23.041  1.00 37.67 ? 442 HOH A O   1 
HETATM 1789 O  O   . HOH I 3 .   ? 13.246  3.263   9.213   1.00 36.62 ? 443 HOH A O   1 
HETATM 1790 O  O   . HOH I 3 .   ? -4.685  12.168  24.947  1.00 37.95 ? 444 HOH A O   1 
HETATM 1791 O  O   . HOH I 3 .   ? -16.513 -12.550 24.409  1.00 35.91 ? 445 HOH A O   1 
HETATM 1792 O  O   . HOH I 3 .   ? 9.988   -6.665  15.950  1.00 38.87 ? 446 HOH A O   1 
HETATM 1793 O  O   . HOH I 3 .   ? 7.912   -3.235  -5.104  1.00 34.03 ? 447 HOH A O   1 
HETATM 1794 O  O   . HOH I 3 .   ? 16.984  4.647   28.203  1.00 31.65 ? 448 HOH A O   1 
HETATM 1795 O  O   . HOH I 3 .   ? -8.997  4.277   21.588  1.00 33.03 ? 449 HOH A O   1 
HETATM 1796 O  O   . HOH I 3 .   ? 8.211   -1.590  21.224  1.00 40.50 ? 450 HOH A O   1 
HETATM 1797 O  O   . HOH I 3 .   ? -4.949  -17.199 0.217   1.00 33.64 ? 451 HOH A O   1 
HETATM 1798 O  O   . HOH I 3 .   ? 3.305   -7.823  17.497  1.00 23.27 ? 452 HOH A O   1 
HETATM 1799 O  O   . HOH I 3 .   ? 15.095  -7.835  26.731  1.00 37.31 ? 453 HOH A O   1 
HETATM 1800 O  O   . HOH I 3 .   ? -19.576 5.911   4.573   1.00 51.90 ? 454 HOH A O   1 
HETATM 1801 O  O   . HOH I 3 .   ? -9.180  -10.848 31.666  1.00 31.91 ? 455 HOH A O   1 
HETATM 1802 O  O   . HOH I 3 .   ? -3.721  -15.540 -1.500  1.00 27.27 ? 456 HOH A O   1 
HETATM 1803 O  O   . HOH I 3 .   ? 10.728  10.112  7.766   1.00 41.16 ? 457 HOH A O   1 
HETATM 1804 O  O   . HOH I 3 .   ? 2.270   1.496   -12.840 1.00 39.01 ? 458 HOH A O   1 
HETATM 1805 O  O   . HOH I 3 .   ? 6.261   14.086  6.885   1.00 36.86 ? 459 HOH A O   1 
HETATM 1806 O  O   . HOH I 3 .   ? 13.707  7.850   32.149  1.00 34.72 ? 460 HOH A O   1 
HETATM 1807 O  O   . HOH I 3 .   ? -13.661 -2.901  32.940  1.00 44.63 ? 461 HOH A O   1 
HETATM 1808 O  O   . HOH I 3 .   ? 5.622   17.479  26.152  1.00 34.88 ? 462 HOH A O   1 
HETATM 1809 O  O   . HOH I 3 .   ? -10.596 -0.247  -7.262  1.00 47.94 ? 463 HOH A O   1 
HETATM 1810 O  O   . HOH I 3 .   ? 12.354  7.004   28.528  1.00 23.80 ? 464 HOH A O   1 
HETATM 1811 O  O   . HOH I 3 .   ? -15.727 -2.106  18.171  1.00 33.43 ? 465 HOH A O   1 
HETATM 1812 O  O   . HOH I 3 .   ? 0.072   10.266  5.417   1.00 24.98 ? 466 HOH A O   1 
HETATM 1813 O  O   . HOH I 3 .   ? 12.700  3.536   11.702  1.00 31.80 ? 467 HOH A O   1 
HETATM 1814 O  O   . HOH I 3 .   ? -1.850  7.292   -2.075  1.00 44.03 ? 468 HOH A O   1 
HETATM 1815 O  O   . HOH I 3 .   ? 5.898   15.141  13.069  1.00 30.81 ? 469 HOH A O   1 
HETATM 1816 O  O   . HOH I 3 .   ? 6.277   -6.146  -1.028  1.00 30.99 ? 470 HOH A O   1 
HETATM 1817 O  O   . HOH I 3 .   ? -4.155  10.298  27.506  1.00 28.15 ? 471 HOH A O   1 
HETATM 1818 O  O   . HOH I 3 .   ? 9.808   0.450   13.457  1.00 33.94 ? 472 HOH A O   1 
HETATM 1819 O  O   . HOH I 3 .   ? -2.264  16.916  0.027   1.00 38.82 ? 473 HOH A O   1 
HETATM 1820 O  O   . HOH I 3 .   ? -7.876  -3.218  34.198  1.00 35.95 ? 474 HOH A O   1 
HETATM 1821 O  O   . HOH I 3 .   ? -8.199  -15.343 21.592  1.00 32.48 ? 475 HOH A O   1 
HETATM 1822 O  O   . HOH I 3 .   ? 9.966   -3.152  7.641   1.00 29.70 ? 476 HOH A O   1 
HETATM 1823 O  O   . HOH I 3 .   ? -14.297 0.991   -1.634  1.00 43.61 ? 477 HOH A O   1 
HETATM 1824 O  O   . HOH I 3 .   ? 6.347   12.247  9.757   1.00 36.94 ? 478 HOH A O   1 
HETATM 1825 O  O   . HOH I 3 .   ? 6.938   -0.898  18.423  1.00 29.59 ? 479 HOH A O   1 
HETATM 1826 O  O   . HOH I 3 .   ? -1.556  13.671  31.088  1.00 29.45 ? 480 HOH A O   1 
HETATM 1827 O  O   . HOH I 3 .   ? -10.579 -4.440  32.454  1.00 33.55 ? 481 HOH A O   1 
HETATM 1828 O  O   . HOH I 3 .   ? 11.672  7.181   6.674   1.00 26.10 ? 482 HOH A O   1 
HETATM 1829 O  O   . HOH I 3 .   ? -8.665  12.695  23.836  1.00 31.47 ? 483 HOH A O   1 
HETATM 1830 O  O   . HOH I 3 .   ? 5.628   -8.522  16.240  1.00 26.68 ? 484 HOH A O   1 
HETATM 1831 O  O   . HOH I 3 .   ? 12.610  10.459  22.539  1.00 30.75 ? 485 HOH A O   1 
HETATM 1832 O  O   . HOH I 3 .   ? -10.368 12.487  13.205  1.00 34.50 ? 486 HOH A O   1 
HETATM 1833 O  O   . HOH I 3 .   ? -11.286 15.474  18.710  1.00 37.13 ? 487 HOH A O   1 
HETATM 1834 O  O   . HOH I 3 .   ? 13.244  6.992   16.706  1.00 37.48 ? 488 HOH A O   1 
HETATM 1835 O  O   . HOH I 3 .   ? 15.595  0.539   17.820  1.00 40.61 ? 489 HOH A O   1 
HETATM 1836 O  O   . HOH I 3 .   ? -6.935  10.916  28.683  1.00 36.08 ? 490 HOH A O   1 
HETATM 1837 O  O   . HOH I 3 .   ? 11.046  10.047  29.835  1.00 33.23 ? 491 HOH A O   1 
HETATM 1838 O  O   . HOH I 3 .   ? -10.338 -5.316  3.151   1.00 32.51 ? 492 HOH A O   1 
HETATM 1839 O  O   . HOH I 3 .   ? -12.054 -16.346 19.033  1.00 47.27 ? 493 HOH A O   1 
HETATM 1840 O  O   . HOH I 3 .   ? 3.528   12.088  37.705  1.00 33.48 ? 494 HOH A O   1 
HETATM 1841 O  O   . HOH I 3 .   ? -10.585 -14.962 19.982  1.00 46.75 ? 495 HOH A O   1 
HETATM 1842 O  O   . HOH I 3 .   ? 3.197   -16.236 -4.175  1.00 43.41 ? 496 HOH A O   1 
HETATM 1843 O  O   . HOH I 3 .   ? -1.203  -19.559 18.964  1.00 38.27 ? 497 HOH A O   1 
HETATM 1844 O  O   . HOH I 3 .   ? -2.273  -19.136 0.174   1.00 38.64 ? 498 HOH A O   1 
HETATM 1845 O  O   . HOH I 3 .   ? -20.986 5.472   7.943   1.00 39.24 ? 499 HOH A O   1 
HETATM 1846 O  O   . HOH I 3 .   ? 6.571   -6.529  23.357  1.00 23.91 ? 500 HOH A O   1 
HETATM 1847 O  O   . HOH I 3 .   ? -4.702  -1.347  35.341  1.00 26.00 ? 501 HOH A O   1 
HETATM 1848 O  O   . HOH I 3 .   ? -2.882  14.061  20.463  1.00 37.17 ? 502 HOH A O   1 
HETATM 1849 O  O   . HOH I 3 .   ? 5.477   -8.739  22.208  1.00 31.28 ? 503 HOH A O   1 
HETATM 1850 O  O   . HOH I 3 .   ? -1.697  3.382   -3.036  1.00 44.85 ? 504 HOH A O   1 
HETATM 1851 O  O   . HOH I 3 .   ? -14.023 -2.680  7.727   1.00 37.91 ? 505 HOH A O   1 
HETATM 1852 O  O   . HOH I 3 .   ? -13.010 13.590  19.636  1.00 32.98 ? 506 HOH A O   1 
HETATM 1853 O  O   . HOH I 3 .   ? -20.073 6.785   28.698  1.00 36.51 ? 507 HOH A O   1 
HETATM 1854 O  O   . HOH I 3 .   ? -0.590  3.342   37.801  1.00 40.54 ? 508 HOH A O   1 
HETATM 1855 O  O   . HOH I 3 .   ? -0.824  13.774  -1.469  1.00 47.54 ? 509 HOH A O   1 
HETATM 1856 O  O   . HOH I 3 .   ? 6.901   7.454   1.944   1.00 34.18 ? 510 HOH A O   1 
HETATM 1857 O  O   . HOH I 3 .   ? -1.691  -15.664 23.359  1.00 32.12 ? 511 HOH A O   1 
HETATM 1858 O  O   . HOH I 3 .   ? -3.955  -17.160 16.231  1.00 36.47 ? 512 HOH A O   1 
HETATM 1859 O  O   . HOH I 3 .   ? 8.418   0.750   16.691  1.00 31.19 ? 513 HOH A O   1 
HETATM 1860 O  O   . HOH I 3 .   ? -3.242  -17.277 27.921  1.00 40.81 ? 514 HOH A O   1 
HETATM 1861 O  O   . HOH I 3 .   ? -6.944  13.504  13.568  1.00 41.99 ? 515 HOH A O   1 
HETATM 1862 O  O   . HOH I 3 .   ? -2.649  -1.883  19.364  1.00 35.78 ? 516 HOH A O   1 
HETATM 1863 O  O   . HOH I 3 .   ? 7.090   -17.389 17.975  1.00 44.86 ? 517 HOH A O   1 
HETATM 1864 O  O   . HOH I 3 .   ? 3.783   11.025  1.791   1.00 42.43 ? 518 HOH A O   1 
HETATM 1865 O  O   . HOH I 3 .   ? -6.927  15.650  19.779  1.00 34.01 ? 519 HOH A O   1 
HETATM 1866 O  O   . HOH I 3 .   ? -6.049  -11.783 -2.386  1.00 43.42 ? 520 HOH A O   1 
HETATM 1867 O  O   . HOH I 3 .   ? 15.319  2.120   20.625  1.00 47.56 ? 521 HOH A O   1 
HETATM 1868 O  O   . HOH I 3 .   ? -17.697 5.987   37.594  1.00 50.20 ? 522 HOH A O   1 
HETATM 1869 O  O   . HOH I 3 .   ? -4.327  14.091  18.897  1.00 43.37 ? 523 HOH A O   1 
HETATM 1870 O  O   . HOH I 3 .   ? 3.443   -5.168  40.475  1.00 44.85 ? 524 HOH A O   1 
HETATM 1871 O  O   . HOH I 3 .   ? 14.115  5.455   12.489  1.00 36.99 ? 525 HOH A O   1 
HETATM 1872 O  O   . HOH I 3 .   ? 13.426  13.048  16.955  1.00 51.98 ? 526 HOH A O   1 
HETATM 1873 O  O   . HOH I 3 .   ? -3.853  -18.756 18.354  1.00 31.89 ? 527 HOH A O   1 
HETATM 1874 O  O   . HOH I 3 .   ? -10.583 3.731   -3.376  1.00 46.44 ? 528 HOH A O   1 
HETATM 1875 O  O   . HOH I 3 .   ? 11.274  7.254   3.972   1.00 37.15 ? 529 HOH A O   1 
HETATM 1876 O  O   . HOH I 3 .   ? -13.589 -16.293 21.544  1.00 50.14 ? 530 HOH A O   1 
HETATM 1877 O  O   . HOH I 3 .   ? 7.244   14.714  30.821  1.00 45.81 ? 531 HOH A O   1 
HETATM 1878 O  O   . HOH I 3 .   ? -13.584 -2.645  4.897   1.00 40.53 ? 532 HOH A O   1 
HETATM 1879 O  O   . HOH I 3 .   ? 5.523   15.644  21.234  1.00 41.47 ? 533 HOH A O   1 
HETATM 1880 O  O   . HOH I 3 .   ? -20.795 10.342  2.763   1.00 50.02 ? 534 HOH A O   1 
HETATM 1881 O  O   . HOH I 3 .   ? -9.583  -17.174 22.355  1.00 48.72 ? 535 HOH A O   1 
HETATM 1882 O  O   . HOH I 3 .   ? -7.541  -16.766 13.235  1.00 34.69 ? 536 HOH A O   1 
HETATM 1883 O  O   . HOH I 3 .   ? -0.757  12.901  36.702  1.00 46.80 ? 537 HOH A O   1 
HETATM 1884 O  O   . HOH I 3 .   ? 11.018  11.105  13.552  1.00 39.82 ? 538 HOH A O   1 
HETATM 1885 O  O   . HOH I 3 .   ? -4.334  13.725  2.585   1.00 49.26 ? 539 HOH A O   1 
HETATM 1886 O  O   . HOH I 3 .   ? -1.542  -15.568 26.035  1.00 39.27 ? 540 HOH A O   1 
HETATM 1887 O  O   . HOH I 3 .   ? -5.609  6.473   36.613  1.00 49.39 ? 541 HOH A O   1 
HETATM 1888 O  O   . HOH I 3 .   ? 9.024   9.496   2.725   1.00 47.53 ? 542 HOH A O   1 
HETATM 1889 O  O   . HOH I 3 .   ? -10.156 -12.807 17.761  1.00 41.29 ? 543 HOH A O   1 
HETATM 1890 O  O   . HOH I 3 .   ? -9.974  -13.987 6.101   1.00 46.16 ? 544 HOH A O   1 
HETATM 1891 O  O   . HOH I 3 .   ? -6.730  7.449   -4.650  1.00 47.45 ? 545 HOH A O   1 
HETATM 1892 O  O   . HOH I 3 .   ? 5.363   18.049  6.065   1.00 40.58 ? 546 HOH A O   1 
HETATM 1893 O  O   . HOH I 3 .   ? 12.318  -8.619  14.651  1.00 53.09 ? 547 HOH A O   1 
HETATM 1894 O  O   . HOH I 3 .   ? -4.545  -17.538 21.001  1.00 31.41 ? 548 HOH A O   1 
HETATM 1895 O  O   . HOH I 3 .   ? 15.698  -14.897 38.071  1.00 35.49 ? 549 HOH A O   1 
HETATM 1896 O  O   . HOH I 3 .   ? -10.252 -10.295 18.183  1.00 39.11 ? 550 HOH A O   1 
HETATM 1897 O  O   . HOH I 3 .   ? -7.136  12.861  25.937  1.00 31.90 ? 551 HOH A O   1 
HETATM 1898 O  O   . HOH I 3 .   ? -11.730 -17.609 21.812  1.00 39.20 ? 552 HOH A O   1 
HETATM 1899 O  O   . HOH I 3 .   ? -17.477 11.054  18.351  1.00 46.61 ? 553 HOH A O   1 
HETATM 1900 O  O   . HOH I 3 .   ? -1.399  14.235  33.823  1.00 41.46 ? 554 HOH A O   1 
HETATM 1901 O  O   . HOH I 3 .   ? 1.916   -20.125 18.229  1.00 50.23 ? 555 HOH A O   1 
HETATM 1902 O  O   . HOH I 3 .   ? 7.230   14.745  15.740  1.00 34.11 ? 556 HOH A O   1 
HETATM 1903 O  O   . HOH I 3 .   ? -14.621 -5.587  9.457   1.00 54.64 ? 557 HOH A O   1 
HETATM 1904 O  O   . HOH I 3 .   ? -5.510  -18.261 14.383  1.00 36.90 ? 558 HOH A O   1 
HETATM 1905 O  O   . HOH I 3 .   ? 7.503   14.581  11.218  1.00 37.67 ? 559 HOH A O   1 
HETATM 1906 O  O   . HOH I 3 .   ? -0.827  16.074  29.834  1.00 41.88 ? 560 HOH A O   1 
HETATM 1907 O  O   . HOH I 3 .   ? -16.513 -1.518  7.403   1.00 40.20 ? 561 HOH A O   1 
HETATM 1908 O  O   . HOH I 3 .   ? 1.028   15.422  34.625  1.00 39.60 ? 562 HOH A O   1 
HETATM 1909 O  O   . HOH I 3 .   ? -3.546  15.421  34.960  1.00 45.15 ? 563 HOH A O   1 
# 
