data_9LAF
# 
_entry.id   9LAF 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9LAF         pdb_00009laf 10.2210/pdb9laf/pdb 
WWPDB D_1300055313 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-05-21 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9LAF 
_pdbx_database_status.recvd_initial_deposition_date   2025-01-02 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              bilee@ncc.re.kr 
_pdbx_contact_author.name_first         'BYUNG IL' 
_pdbx_contact_author.name_last          LEE 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-1270-8439 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Kim, S.'   1 0009-0007-5794-1951 
'Lee, B.I.' 2 0000-0003-1270-8439 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Biochem.Biophys.Res.Commun. 
_citation.journal_id_ASTM           BBRCA9 
_citation.journal_id_CSD            0146 
_citation.journal_id_ISSN           1090-2104 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            759 
_citation.language                  ? 
_citation.page_first                151691 
_citation.page_last                 151691 
_citation.title                     'Structural analysis of EPOP BC-box binding to the elongin BC complex.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.bbrc.2025.151691 
_citation.pdbx_database_id_PubMed   40153999 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kim, S.'   1 ? 
primary 'Yeo, H.'   2 ? 
primary 'Lee, B.I.' 3 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man Elongin-B                                                         11748.406 1   ? ? ? ? 
2 polymer man Elongin-C                                                         10843.420 1   ? ? ? ? 
3 polymer man 'Elongin BC and Polycomb repressive complex 2-associated protein' 2959.478  1   ? ? ? ? 
4 water   nat water                                                             18.015    104 ? ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 
;EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
;
2 
;EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
;
3 'Proline-rich protein 28' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFR
ADDTFEALCIEPFSSPPELPDVMK
;
;MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFR
ADDTFEALCIEPFSSPPELPDVMK
;
B ? 
2 'polypeptide(L)' no no 
;MYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIA
PEIALELLMAANFLDC
;
;MYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIA
PEIALELLMAANFLDC
;
C ? 
3 'polypeptide(L)' no no MHHHHHHGSEFSPLCLRALAFCALAK MHHHHHHGSEFSPLCLRALAFCALAK A ? 
# 
_pdbx_entity_nonpoly.entity_id   4 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ASP n 
1 3   VAL n 
1 4   PHE n 
1 5   LEU n 
1 6   MET n 
1 7   ILE n 
1 8   ARG n 
1 9   ARG n 
1 10  HIS n 
1 11  LYS n 
1 12  THR n 
1 13  THR n 
1 14  ILE n 
1 15  PHE n 
1 16  THR n 
1 17  ASP n 
1 18  ALA n 
1 19  LYS n 
1 20  GLU n 
1 21  SER n 
1 22  SER n 
1 23  THR n 
1 24  VAL n 
1 25  PHE n 
1 26  GLU n 
1 27  LEU n 
1 28  LYS n 
1 29  ARG n 
1 30  ILE n 
1 31  VAL n 
1 32  GLU n 
1 33  GLY n 
1 34  ILE n 
1 35  LEU n 
1 36  LYS n 
1 37  ARG n 
1 38  PRO n 
1 39  PRO n 
1 40  ASP n 
1 41  GLU n 
1 42  GLN n 
1 43  ARG n 
1 44  LEU n 
1 45  TYR n 
1 46  LYS n 
1 47  ASP n 
1 48  ASP n 
1 49  GLN n 
1 50  LEU n 
1 51  LEU n 
1 52  ASP n 
1 53  ASP n 
1 54  GLY n 
1 55  LYS n 
1 56  THR n 
1 57  LEU n 
1 58  GLY n 
1 59  GLU n 
1 60  CYS n 
1 61  GLY n 
1 62  PHE n 
1 63  THR n 
1 64  SER n 
1 65  GLN n 
1 66  THR n 
1 67  ALA n 
1 68  ARG n 
1 69  PRO n 
1 70  GLN n 
1 71  ALA n 
1 72  PRO n 
1 73  ALA n 
1 74  THR n 
1 75  VAL n 
1 76  GLY n 
1 77  LEU n 
1 78  ALA n 
1 79  PHE n 
1 80  ARG n 
1 81  ALA n 
1 82  ASP n 
1 83  ASP n 
1 84  THR n 
1 85  PHE n 
1 86  GLU n 
1 87  ALA n 
1 88  LEU n 
1 89  CYS n 
1 90  ILE n 
1 91  GLU n 
1 92  PRO n 
1 93  PHE n 
1 94  SER n 
1 95  SER n 
1 96  PRO n 
1 97  PRO n 
1 98  GLU n 
1 99  LEU n 
1 100 PRO n 
1 101 ASP n 
1 102 VAL n 
1 103 MET n 
1 104 LYS n 
2 1   MET n 
2 2   TYR n 
2 3   VAL n 
2 4   LYS n 
2 5   LEU n 
2 6   ILE n 
2 7   SER n 
2 8   SER n 
2 9   ASP n 
2 10  GLY n 
2 11  HIS n 
2 12  GLU n 
2 13  PHE n 
2 14  ILE n 
2 15  VAL n 
2 16  LYS n 
2 17  ARG n 
2 18  GLU n 
2 19  HIS n 
2 20  ALA n 
2 21  LEU n 
2 22  THR n 
2 23  SER n 
2 24  GLY n 
2 25  THR n 
2 26  ILE n 
2 27  LYS n 
2 28  ALA n 
2 29  MET n 
2 30  LEU n 
2 31  SER n 
2 32  GLY n 
2 33  PRO n 
2 34  GLY n 
2 35  GLN n 
2 36  PHE n 
2 37  ALA n 
2 38  GLU n 
2 39  ASN n 
2 40  GLU n 
2 41  THR n 
2 42  ASN n 
2 43  GLU n 
2 44  VAL n 
2 45  ASN n 
2 46  PHE n 
2 47  ARG n 
2 48  GLU n 
2 49  ILE n 
2 50  PRO n 
2 51  SER n 
2 52  HIS n 
2 53  VAL n 
2 54  LEU n 
2 55  SER n 
2 56  LYS n 
2 57  VAL n 
2 58  CYS n 
2 59  MET n 
2 60  TYR n 
2 61  PHE n 
2 62  THR n 
2 63  TYR n 
2 64  LYS n 
2 65  VAL n 
2 66  ARG n 
2 67  TYR n 
2 68  THR n 
2 69  ASN n 
2 70  SER n 
2 71  SER n 
2 72  THR n 
2 73  GLU n 
2 74  ILE n 
2 75  PRO n 
2 76  GLU n 
2 77  PHE n 
2 78  PRO n 
2 79  ILE n 
2 80  ALA n 
2 81  PRO n 
2 82  GLU n 
2 83  ILE n 
2 84  ALA n 
2 85  LEU n 
2 86  GLU n 
2 87  LEU n 
2 88  LEU n 
2 89  MET n 
2 90  ALA n 
2 91  ALA n 
2 92  ASN n 
2 93  PHE n 
2 94  LEU n 
2 95  ASP n 
2 96  CYS n 
3 1   MET n 
3 2   HIS n 
3 3   HIS n 
3 4   HIS n 
3 5   HIS n 
3 6   HIS n 
3 7   HIS n 
3 8   GLY n 
3 9   SER n 
3 10  GLU n 
3 11  PHE n 
3 12  SER n 
3 13  PRO n 
3 14  LEU n 
3 15  CYS n 
3 16  LEU n 
3 17  ARG n 
3 18  ALA n 
3 19  LEU n 
3 20  ALA n 
3 21  PHE n 
3 22  CYS n 
3 23  ALA n 
3 24  LEU n 
3 25  ALA n 
3 26  LYS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 104 human ? 'ELOB, TCEB2'           ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli BL21(DE3)' 469008 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? pACYCDuet-1 ? ? 
2 1 sample 'Biological sequence' 1 96  human ? 'ELOC, TCEB1'           ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli BL21(DE3)' 469008 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? pACYCDuet-1 ? ? 
3 1 sample 'Biological sequence' 1 26  human ? 'EPOP, C17orf96, PRR28' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli BL21(DE3)' 469008 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?           ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   1   MET MET B . n 
A 1 2   ASP 2   2   2   ASP ASP B . n 
A 1 3   VAL 3   3   3   VAL VAL B . n 
A 1 4   PHE 4   4   4   PHE PHE B . n 
A 1 5   LEU 5   5   5   LEU LEU B . n 
A 1 6   MET 6   6   6   MET MET B . n 
A 1 7   ILE 7   7   7   ILE ILE B . n 
A 1 8   ARG 8   8   8   ARG ARG B . n 
A 1 9   ARG 9   9   9   ARG ARG B . n 
A 1 10  HIS 10  10  10  HIS HIS B . n 
A 1 11  LYS 11  11  11  LYS LYS B . n 
A 1 12  THR 12  12  12  THR THR B . n 
A 1 13  THR 13  13  13  THR THR B . n 
A 1 14  ILE 14  14  14  ILE ILE B . n 
A 1 15  PHE 15  15  15  PHE PHE B . n 
A 1 16  THR 16  16  16  THR THR B . n 
A 1 17  ASP 17  17  17  ASP ASP B . n 
A 1 18  ALA 18  18  18  ALA ALA B . n 
A 1 19  LYS 19  19  19  LYS LYS B . n 
A 1 20  GLU 20  20  20  GLU GLU B . n 
A 1 21  SER 21  21  21  SER SER B . n 
A 1 22  SER 22  22  22  SER SER B . n 
A 1 23  THR 23  23  23  THR THR B . n 
A 1 24  VAL 24  24  24  VAL VAL B . n 
A 1 25  PHE 25  25  25  PHE PHE B . n 
A 1 26  GLU 26  26  26  GLU GLU B . n 
A 1 27  LEU 27  27  27  LEU LEU B . n 
A 1 28  LYS 28  28  28  LYS LYS B . n 
A 1 29  ARG 29  29  29  ARG ARG B . n 
A 1 30  ILE 30  30  30  ILE ILE B . n 
A 1 31  VAL 31  31  31  VAL VAL B . n 
A 1 32  GLU 32  32  32  GLU GLU B . n 
A 1 33  GLY 33  33  33  GLY GLY B . n 
A 1 34  ILE 34  34  34  ILE ILE B . n 
A 1 35  LEU 35  35  35  LEU LEU B . n 
A 1 36  LYS 36  36  36  LYS LYS B . n 
A 1 37  ARG 37  37  37  ARG ARG B . n 
A 1 38  PRO 38  38  38  PRO PRO B . n 
A 1 39  PRO 39  39  39  PRO PRO B . n 
A 1 40  ASP 40  40  40  ASP ASP B . n 
A 1 41  GLU 41  41  41  GLU GLU B . n 
A 1 42  GLN 42  42  42  GLN GLN B . n 
A 1 43  ARG 43  43  43  ARG ARG B . n 
A 1 44  LEU 44  44  44  LEU LEU B . n 
A 1 45  TYR 45  45  45  TYR TYR B . n 
A 1 46  LYS 46  46  46  LYS LYS B . n 
A 1 47  ASP 47  47  47  ASP ASP B . n 
A 1 48  ASP 48  48  48  ASP ASP B . n 
A 1 49  GLN 49  49  49  GLN GLN B . n 
A 1 50  LEU 50  50  50  LEU LEU B . n 
A 1 51  LEU 51  51  51  LEU LEU B . n 
A 1 52  ASP 52  52  52  ASP ASP B . n 
A 1 53  ASP 53  53  53  ASP ASP B . n 
A 1 54  GLY 54  54  54  GLY GLY B . n 
A 1 55  LYS 55  55  55  LYS LYS B . n 
A 1 56  THR 56  56  56  THR THR B . n 
A 1 57  LEU 57  57  57  LEU LEU B . n 
A 1 58  GLY 58  58  58  GLY GLY B . n 
A 1 59  GLU 59  59  59  GLU GLU B . n 
A 1 60  CYS 60  60  60  CYS CYS B . n 
A 1 61  GLY 61  61  61  GLY GLY B . n 
A 1 62  PHE 62  62  62  PHE PHE B . n 
A 1 63  THR 63  63  63  THR THR B . n 
A 1 64  SER 64  64  64  SER SER B . n 
A 1 65  GLN 65  65  65  GLN GLN B . n 
A 1 66  THR 66  66  66  THR THR B . n 
A 1 67  ALA 67  67  67  ALA ALA B . n 
A 1 68  ARG 68  68  68  ARG ARG B . n 
A 1 69  PRO 69  69  69  PRO PRO B . n 
A 1 70  GLN 70  70  70  GLN GLN B . n 
A 1 71  ALA 71  71  71  ALA ALA B . n 
A 1 72  PRO 72  72  72  PRO PRO B . n 
A 1 73  ALA 73  73  73  ALA ALA B . n 
A 1 74  THR 74  74  74  THR THR B . n 
A 1 75  VAL 75  75  75  VAL VAL B . n 
A 1 76  GLY 76  76  76  GLY GLY B . n 
A 1 77  LEU 77  77  77  LEU LEU B . n 
A 1 78  ALA 78  78  78  ALA ALA B . n 
A 1 79  PHE 79  79  79  PHE PHE B . n 
A 1 80  ARG 80  80  80  ARG ARG B . n 
A 1 81  ALA 81  81  81  ALA ALA B . n 
A 1 82  ASP 82  82  ?   ?   ?   B . n 
A 1 83  ASP 83  83  ?   ?   ?   B . n 
A 1 84  THR 84  84  ?   ?   ?   B . n 
A 1 85  PHE 85  85  85  PHE PHE B . n 
A 1 86  GLU 86  86  86  GLU GLU B . n 
A 1 87  ALA 87  87  87  ALA ALA B . n 
A 1 88  LEU 88  88  88  LEU LEU B . n 
A 1 89  CYS 89  89  89  CYS CYS B . n 
A 1 90  ILE 90  90  90  ILE ILE B . n 
A 1 91  GLU 91  91  91  GLU GLU B . n 
A 1 92  PRO 92  92  92  PRO PRO B . n 
A 1 93  PHE 93  93  93  PHE PHE B . n 
A 1 94  SER 94  94  94  SER SER B . n 
A 1 95  SER 95  95  95  SER SER B . n 
A 1 96  PRO 96  96  ?   ?   ?   B . n 
A 1 97  PRO 97  97  ?   ?   ?   B . n 
A 1 98  GLU 98  98  ?   ?   ?   B . n 
A 1 99  LEU 99  99  ?   ?   ?   B . n 
A 1 100 PRO 100 100 ?   ?   ?   B . n 
A 1 101 ASP 101 101 ?   ?   ?   B . n 
A 1 102 VAL 102 102 ?   ?   ?   B . n 
A 1 103 MET 103 103 ?   ?   ?   B . n 
A 1 104 LYS 104 104 ?   ?   ?   B . n 
B 2 1   MET 1   17  17  MET MET C . n 
B 2 2   TYR 2   18  18  TYR TYR C . n 
B 2 3   VAL 3   19  19  VAL VAL C . n 
B 2 4   LYS 4   20  20  LYS LYS C . n 
B 2 5   LEU 5   21  21  LEU LEU C . n 
B 2 6   ILE 6   22  22  ILE ILE C . n 
B 2 7   SER 7   23  23  SER SER C . n 
B 2 8   SER 8   24  24  SER SER C . n 
B 2 9   ASP 9   25  25  ASP ASP C . n 
B 2 10  GLY 10  26  26  GLY GLY C . n 
B 2 11  HIS 11  27  27  HIS HIS C . n 
B 2 12  GLU 12  28  28  GLU GLU C . n 
B 2 13  PHE 13  29  29  PHE PHE C . n 
B 2 14  ILE 14  30  30  ILE ILE C . n 
B 2 15  VAL 15  31  31  VAL VAL C . n 
B 2 16  LYS 16  32  32  LYS LYS C . n 
B 2 17  ARG 17  33  33  ARG ARG C . n 
B 2 18  GLU 18  34  34  GLU GLU C . n 
B 2 19  HIS 19  35  35  HIS HIS C . n 
B 2 20  ALA 20  36  36  ALA ALA C . n 
B 2 21  LEU 21  37  37  LEU LEU C . n 
B 2 22  THR 22  38  38  THR THR C . n 
B 2 23  SER 23  39  39  SER SER C . n 
B 2 24  GLY 24  40  40  GLY GLY C . n 
B 2 25  THR 25  41  41  THR THR C . n 
B 2 26  ILE 26  42  42  ILE ILE C . n 
B 2 27  LYS 27  43  43  LYS LYS C . n 
B 2 28  ALA 28  44  44  ALA ALA C . n 
B 2 29  MET 29  45  45  MET MET C . n 
B 2 30  LEU 30  46  46  LEU LEU C . n 
B 2 31  SER 31  47  47  SER SER C . n 
B 2 32  GLY 32  48  ?   ?   ?   C . n 
B 2 33  PRO 33  49  ?   ?   ?   C . n 
B 2 34  GLY 34  50  ?   ?   ?   C . n 
B 2 35  GLN 35  51  ?   ?   ?   C . n 
B 2 36  PHE 36  52  ?   ?   ?   C . n 
B 2 37  ALA 37  53  ?   ?   ?   C . n 
B 2 38  GLU 38  54  ?   ?   ?   C . n 
B 2 39  ASN 39  55  ?   ?   ?   C . n 
B 2 40  GLU 40  56  56  GLU GLU C . n 
B 2 41  THR 41  57  57  THR THR C . n 
B 2 42  ASN 42  58  58  ASN ASN C . n 
B 2 43  GLU 43  59  59  GLU GLU C . n 
B 2 44  VAL 44  60  60  VAL VAL C . n 
B 2 45  ASN 45  61  61  ASN ASN C . n 
B 2 46  PHE 46  62  62  PHE PHE C . n 
B 2 47  ARG 47  63  63  ARG ARG C . n 
B 2 48  GLU 48  64  64  GLU GLU C . n 
B 2 49  ILE 49  65  65  ILE ILE C . n 
B 2 50  PRO 50  66  66  PRO PRO C . n 
B 2 51  SER 51  67  67  SER SER C . n 
B 2 52  HIS 52  68  68  HIS HIS C . n 
B 2 53  VAL 53  69  69  VAL VAL C . n 
B 2 54  LEU 54  70  70  LEU LEU C . n 
B 2 55  SER 55  71  71  SER SER C . n 
B 2 56  LYS 56  72  72  LYS LYS C . n 
B 2 57  VAL 57  73  73  VAL VAL C . n 
B 2 58  CYS 58  74  74  CYS CYS C . n 
B 2 59  MET 59  75  75  MET MET C . n 
B 2 60  TYR 60  76  76  TYR TYR C . n 
B 2 61  PHE 61  77  77  PHE PHE C . n 
B 2 62  THR 62  78  78  THR THR C . n 
B 2 63  TYR 63  79  79  TYR TYR C . n 
B 2 64  LYS 64  80  80  LYS LYS C . n 
B 2 65  VAL 65  81  81  VAL VAL C . n 
B 2 66  ARG 66  82  82  ARG ARG C . n 
B 2 67  TYR 67  83  83  TYR TYR C . n 
B 2 68  THR 68  84  84  THR THR C . n 
B 2 69  ASN 69  85  85  ASN ASN C . n 
B 2 70  SER 70  86  86  SER SER C . n 
B 2 71  SER 71  87  ?   ?   ?   C . n 
B 2 72  THR 72  88  88  THR THR C . n 
B 2 73  GLU 73  89  89  GLU GLU C . n 
B 2 74  ILE 74  90  90  ILE ILE C . n 
B 2 75  PRO 75  91  91  PRO PRO C . n 
B 2 76  GLU 76  92  92  GLU GLU C . n 
B 2 77  PHE 77  93  93  PHE PHE C . n 
B 2 78  PRO 78  94  94  PRO PRO C . n 
B 2 79  ILE 79  95  95  ILE ILE C . n 
B 2 80  ALA 80  96  96  ALA ALA C . n 
B 2 81  PRO 81  97  97  PRO PRO C . n 
B 2 82  GLU 82  98  98  GLU GLU C . n 
B 2 83  ILE 83  99  99  ILE ILE C . n 
B 2 84  ALA 84  100 100 ALA ALA C . n 
B 2 85  LEU 85  101 101 LEU LEU C . n 
B 2 86  GLU 86  102 102 GLU GLU C . n 
B 2 87  LEU 87  103 103 LEU LEU C . n 
B 2 88  LEU 88  104 104 LEU LEU C . n 
B 2 89  MET 89  105 105 MET MET C . n 
B 2 90  ALA 90  106 106 ALA ALA C . n 
B 2 91  ALA 91  107 107 ALA ALA C . n 
B 2 92  ASN 92  108 108 ASN ASN C . n 
B 2 93  PHE 93  109 109 PHE PHE C . n 
B 2 94  LEU 94  110 110 LEU LEU C . n 
B 2 95  ASP 95  111 111 ASP ASP C . n 
B 2 96  CYS 96  112 112 CYS CYS C . n 
C 3 1   MET 1   25  ?   ?   ?   A . n 
C 3 2   HIS 2   26  ?   ?   ?   A . n 
C 3 3   HIS 3   27  ?   ?   ?   A . n 
C 3 4   HIS 4   28  ?   ?   ?   A . n 
C 3 5   HIS 5   29  ?   ?   ?   A . n 
C 3 6   HIS 6   30  ?   ?   ?   A . n 
C 3 7   HIS 7   31  ?   ?   ?   A . n 
C 3 8   GLY 8   32  ?   ?   ?   A . n 
C 3 9   SER 9   33  ?   ?   ?   A . n 
C 3 10  GLU 10  34  ?   ?   ?   A . n 
C 3 11  PHE 11  35  35  PHE PHE A . n 
C 3 12  SER 12  36  36  SER SER A . n 
C 3 13  PRO 13  37  37  PRO PRO A . n 
C 3 14  LEU 14  38  38  LEU LEU A . n 
C 3 15  CYS 15  39  39  CYS CYS A . n 
C 3 16  LEU 16  40  40  LEU LEU A . n 
C 3 17  ARG 17  41  41  ARG ARG A . n 
C 3 18  ALA 18  42  42  ALA ALA A . n 
C 3 19  LEU 19  43  43  LEU LEU A . n 
C 3 20  ALA 20  44  44  ALA ALA A . n 
C 3 21  PHE 21  45  45  PHE PHE A . n 
C 3 22  CYS 22  46  46  CYS CYS A . n 
C 3 23  ALA 23  47  47  ALA ALA A . n 
C 3 24  LEU 24  48  48  LEU LEU A . n 
C 3 25  ALA 25  49  49  ALA ALA A . n 
C 3 26  LYS 26  50  50  LYS LYS A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 4 HOH 1  201 58  HOH HOH B . 
D 4 HOH 2  202 105 HOH HOH B . 
D 4 HOH 3  203 85  HOH HOH B . 
D 4 HOH 4  204 5   HOH HOH B . 
D 4 HOH 5  205 21  HOH HOH B . 
D 4 HOH 6  206 34  HOH HOH B . 
D 4 HOH 7  207 33  HOH HOH B . 
D 4 HOH 8  208 94  HOH HOH B . 
D 4 HOH 9  209 101 HOH HOH B . 
D 4 HOH 10 210 11  HOH HOH B . 
D 4 HOH 11 211 70  HOH HOH B . 
D 4 HOH 12 212 20  HOH HOH B . 
D 4 HOH 13 213 47  HOH HOH B . 
D 4 HOH 14 214 46  HOH HOH B . 
D 4 HOH 15 215 30  HOH HOH B . 
D 4 HOH 16 216 13  HOH HOH B . 
D 4 HOH 17 217 26  HOH HOH B . 
D 4 HOH 18 218 28  HOH HOH B . 
D 4 HOH 19 219 35  HOH HOH B . 
D 4 HOH 20 220 29  HOH HOH B . 
D 4 HOH 21 221 39  HOH HOH B . 
D 4 HOH 22 222 14  HOH HOH B . 
D 4 HOH 23 223 24  HOH HOH B . 
D 4 HOH 24 224 103 HOH HOH B . 
D 4 HOH 25 225 8   HOH HOH B . 
D 4 HOH 26 226 1   HOH HOH B . 
D 4 HOH 27 227 12  HOH HOH B . 
D 4 HOH 28 228 83  HOH HOH B . 
D 4 HOH 29 229 3   HOH HOH B . 
D 4 HOH 30 230 69  HOH HOH B . 
D 4 HOH 31 231 45  HOH HOH B . 
D 4 HOH 32 232 95  HOH HOH B . 
D 4 HOH 33 233 4   HOH HOH B . 
D 4 HOH 34 234 50  HOH HOH B . 
D 4 HOH 35 235 60  HOH HOH B . 
D 4 HOH 36 236 57  HOH HOH B . 
D 4 HOH 37 237 18  HOH HOH B . 
D 4 HOH 38 238 7   HOH HOH B . 
D 4 HOH 39 239 48  HOH HOH B . 
D 4 HOH 40 240 55  HOH HOH B . 
D 4 HOH 41 241 17  HOH HOH B . 
D 4 HOH 42 242 51  HOH HOH B . 
D 4 HOH 43 243 9   HOH HOH B . 
D 4 HOH 44 244 71  HOH HOH B . 
D 4 HOH 45 245 38  HOH HOH B . 
D 4 HOH 46 246 41  HOH HOH B . 
D 4 HOH 47 247 61  HOH HOH B . 
D 4 HOH 48 248 90  HOH HOH B . 
D 4 HOH 49 249 65  HOH HOH B . 
D 4 HOH 50 250 88  HOH HOH B . 
D 4 HOH 51 251 97  HOH HOH B . 
D 4 HOH 52 252 78  HOH HOH B . 
D 4 HOH 53 253 40  HOH HOH B . 
D 4 HOH 54 254 86  HOH HOH B . 
D 4 HOH 55 255 22  HOH HOH B . 
D 4 HOH 56 256 66  HOH HOH B . 
D 4 HOH 57 257 16  HOH HOH B . 
D 4 HOH 58 258 82  HOH HOH B . 
D 4 HOH 59 259 91  HOH HOH B . 
D 4 HOH 60 260 68  HOH HOH B . 
D 4 HOH 61 261 87  HOH HOH B . 
D 4 HOH 62 262 92  HOH HOH B . 
D 4 HOH 63 263 84  HOH HOH B . 
D 4 HOH 64 264 81  HOH HOH B . 
D 4 HOH 65 265 64  HOH HOH B . 
E 4 HOH 1  201 73  HOH HOH C . 
E 4 HOH 2  202 106 HOH HOH C . 
E 4 HOH 3  203 53  HOH HOH C . 
E 4 HOH 4  204 52  HOH HOH C . 
E 4 HOH 5  205 102 HOH HOH C . 
E 4 HOH 6  206 74  HOH HOH C . 
E 4 HOH 7  207 44  HOH HOH C . 
E 4 HOH 8  208 37  HOH HOH C . 
E 4 HOH 9  209 32  HOH HOH C . 
E 4 HOH 10 210 49  HOH HOH C . 
E 4 HOH 11 211 31  HOH HOH C . 
E 4 HOH 12 212 89  HOH HOH C . 
E 4 HOH 13 213 80  HOH HOH C . 
E 4 HOH 14 214 6   HOH HOH C . 
E 4 HOH 15 215 23  HOH HOH C . 
E 4 HOH 16 216 43  HOH HOH C . 
E 4 HOH 17 217 75  HOH HOH C . 
E 4 HOH 18 218 100 HOH HOH C . 
E 4 HOH 19 219 25  HOH HOH C . 
E 4 HOH 20 220 104 HOH HOH C . 
E 4 HOH 21 221 76  HOH HOH C . 
E 4 HOH 22 222 27  HOH HOH C . 
E 4 HOH 23 223 77  HOH HOH C . 
E 4 HOH 24 224 72  HOH HOH C . 
E 4 HOH 25 225 10  HOH HOH C . 
E 4 HOH 26 226 15  HOH HOH C . 
E 4 HOH 27 227 96  HOH HOH C . 
E 4 HOH 28 228 2   HOH HOH C . 
E 4 HOH 29 229 54  HOH HOH C . 
E 4 HOH 30 230 42  HOH HOH C . 
E 4 HOH 31 231 36  HOH HOH C . 
E 4 HOH 32 232 93  HOH HOH C . 
F 4 HOH 1  101 99  HOH HOH A . 
F 4 HOH 2  102 79  HOH HOH A . 
F 4 HOH 3  103 98  HOH HOH A . 
F 4 HOH 4  104 56  HOH HOH A . 
F 4 HOH 5  105 63  HOH HOH A . 
F 4 HOH 6  106 19  HOH HOH A . 
F 4 HOH 7  107 67  HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A PHE 35 ? CD1 ? C PHE 11 CD1 
2 1 Y 1 A PHE 35 ? CD2 ? C PHE 11 CD2 
3 1 Y 1 A PHE 35 ? CE1 ? C PHE 11 CE1 
4 1 Y 1 A PHE 35 ? CE2 ? C PHE 11 CE2 
5 1 Y 1 A PHE 35 ? CZ  ? C PHE 11 CZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.21.1_5286 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9LAF 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     120.151 
_cell.length_a_esd                 ? 
_cell.length_b                     156.613 
_cell.length_b_esd                 ? 
_cell.length_c                     36.817 
_cell.length_c_esd                 ? 
_cell.volume                       692793.168 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9LAF 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                20 
_symmetry.space_group_name_Hall            'C 2c 2' 
_symmetry.space_group_name_H-M             'C 2 2 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9LAF 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.39 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          68.39 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
'15% v/v 2-Propanol, 0.1 M Sodium citrate tribasic dihydrate pH 5.0, 10% w/v Polyethylene glycol 10,000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            294 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-04-11 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97942 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PAL/PLS BEAMLINE 11C' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97942 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   11C 
_diffrn_source.pdbx_synchrotron_site       PAL/PLS 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9LAF 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.14 
_reflns.d_resolution_low                               50.00 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     19316 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.4 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                5.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          16.25 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.995 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.094 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.15 
_reflns_shell.d_res_low                                     2.19 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             788 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.878 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               25.41 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9LAF 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.14 
_refine.ls_d_res_low                             47.88 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     19046 
_refine.ls_number_reflns_R_free                  1907 
_refine.ls_number_reflns_R_work                  17139 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    96.85 
_refine.ls_percent_reflns_R_free                 10.01 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1964 
_refine.ls_R_factor_R_free                       0.2308 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1925 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.37 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 21.6697 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1948 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.14 
_refine_hist.d_res_low                        47.88 
_refine_hist.number_atoms_solvent             104 
_refine_hist.number_atoms_total               1644 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1540 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0073  ? 1566 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8004  ? 2108 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0523  ? 245  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0067  ? 266  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 15.8645 ? 586  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.14 2.20  . . 102 914  74.05 . . . . 0.2092 . . . . . . . . . . . 0.2581 
'X-RAY DIFFRACTION' 2.20 2.26  . . 130 1170 95.24 . . . . 0.1959 . . . . . . . . . . . 0.2663 
'X-RAY DIFFRACTION' 2.26 2.32  . . 137 1234 98.14 . . . . 0.1860 . . . . . . . . . . . 0.2390 
'X-RAY DIFFRACTION' 2.32 2.40  . . 136 1223 98.84 . . . . 0.1968 . . . . . . . . . . . 0.2340 
'X-RAY DIFFRACTION' 2.40 2.48  . . 136 1230 99.13 . . . . 0.1967 . . . . . . . . . . . 0.2379 
'X-RAY DIFFRACTION' 2.48 2.58  . . 137 1221 98.26 . . . . 0.1932 . . . . . . . . . . . 0.2389 
'X-RAY DIFFRACTION' 2.58 2.70  . . 140 1257 99.79 . . . . 0.2081 . . . . . . . . . . . 0.2449 
'X-RAY DIFFRACTION' 2.70 2.84  . . 140 1263 99.79 . . . . 0.1934 . . . . . . . . . . . 0.2230 
'X-RAY DIFFRACTION' 2.84 3.02  . . 138 1237 99.28 . . . . 0.2110 . . . . . . . . . . . 0.2632 
'X-RAY DIFFRACTION' 3.02 3.25  . . 136 1231 98.70 . . . . 0.2046 . . . . . . . . . . . 0.2481 
'X-RAY DIFFRACTION' 3.25 3.58  . . 141 1268 99.58 . . . . 0.1962 . . . . . . . . . . . 0.2381 
'X-RAY DIFFRACTION' 3.58 4.10  . . 143 1277 98.20 . . . . 0.1692 . . . . . . . . . . . 0.2215 
'X-RAY DIFFRACTION' 4.10 5.16  . . 140 1268 98.60 . . . . 0.1666 . . . . . . . . . . . 0.1877 
'X-RAY DIFFRACTION' 5.17 47.88 . . 151 1346 97.72 . . . . 0.2144 . . . . . . . . . . . 0.2291 
# 
_struct.entry_id                     9LAF 
_struct.title                        'Crystal structure of Elongin BC-EPOP peptide' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9LAF 
_struct_keywords.text            'EPOP, Elongin B, Elongin C, TRANSCRIPTION' 
_struct_keywords.pdbx_keywords   TRANSCRIPTION 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
F N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP ELOB_HUMAN Q15370 ? 1 
;MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFR
ADDTFEALCIEPFSSPPELPDVMK
;
1  
2 UNP ELOC_HUMAN Q15369 ? 2 
;MYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIA
PEIALELLMAANFLDC
;
17 
3 UNP EPOP_HUMAN A6NHQ4 ? 3 EFSPLCLRALAFCALAK 34 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9LAF B 1  ? 104 ? Q15370 1  ? 104 ? 1  104 
2 2 9LAF C 1  ? 96  ? Q15369 17 ? 112 ? 17 112 
3 3 9LAF A 10 ? 26  ? A6NHQ4 34 ? 50  ? 34 50  
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
3 9LAF MET A 1 ? UNP A6NHQ4 ? ? 'initiating methionine' 25 1 
3 9LAF HIS A 2 ? UNP A6NHQ4 ? ? 'expression tag'        26 2 
3 9LAF HIS A 3 ? UNP A6NHQ4 ? ? 'expression tag'        27 3 
3 9LAF HIS A 4 ? UNP A6NHQ4 ? ? 'expression tag'        28 4 
3 9LAF HIS A 5 ? UNP A6NHQ4 ? ? 'expression tag'        29 5 
3 9LAF HIS A 6 ? UNP A6NHQ4 ? ? 'expression tag'        30 6 
3 9LAF HIS A 7 ? UNP A6NHQ4 ? ? 'expression tag'        31 7 
3 9LAF GLY A 8 ? UNP A6NHQ4 ? ? 'expression tag'        32 8 
3 9LAF SER A 9 ? UNP A6NHQ4 ? ? 'expression tag'        33 9 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 3210  ? 
1 MORE         -22   ? 
1 'SSA (A^2)'  10110 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 THR A 23 ? LYS A 36 ? THR B 23 LYS B 36  1 ? 14 
HELX_P HELX_P2 AA2 PRO A 38 ? ASP A 40 ? PRO B 38 ASP B 40  5 ? 3  
HELX_P HELX_P3 AA3 THR A 56 ? GLY A 61 ? THR B 56 GLY B 61  1 ? 6  
HELX_P HELX_P4 AA4 ARG B 17 ? LEU B 21 ? ARG C 33 LEU C 37  1 ? 5  
HELX_P HELX_P5 AA5 SER B 23 ? LEU B 30 ? SER C 39 LEU C 46  1 ? 8  
HELX_P HELX_P6 AA6 PRO B 50 ? THR B 68 ? PRO C 66 THR C 84  1 ? 19 
HELX_P HELX_P7 AA7 ALA B 80 ? GLU B 82 ? ALA C 96 GLU C 98  5 ? 3  
HELX_P HELX_P8 AA8 ILE B 83 ? ASP B 95 ? ILE C 99 ASP C 111 1 ? 13 
HELX_P HELX_P9 AA9 CYS C 15 ? LYS C 26 ? CYS A 39 LYS A 50  1 ? 12 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   8 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA1 4 5 ? anti-parallel 
AA1 5 6 ? parallel      
AA1 6 7 ? anti-parallel 
AA1 7 8 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLN A 49 ? LEU A 50 ? GLN B 49 LEU B 50 
AA1 2 GLN A 42 ? LYS A 46 ? GLN B 42 LYS B 46 
AA1 3 ALA A 73 ? PHE A 79 ? ALA B 73 PHE B 79 
AA1 4 ASP A 2  ? ARG A 9  ? ASP B 2  ARG B 9  
AA1 5 THR A 12 ? LYS A 19 ? THR B 12 LYS B 19 
AA1 6 GLU B 12 ? LYS B 16 ? GLU C 28 LYS C 32 
AA1 7 TYR B 2  ? ILE B 6  ? TYR C 18 ILE C 22 
AA1 8 GLU B 43 ? ASN B 45 ? GLU C 59 ASN C 61 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O GLN A 49 ? O GLN B 49 N LYS A 46 ? N LYS B 46 
AA1 2 3 N ARG A 43 ? N ARG B 43 O ALA A 78 ? O ALA B 78 
AA1 3 4 O VAL A 75 ? O VAL B 75 N MET A 6  ? N MET B 6  
AA1 4 5 N VAL A 3  ? N VAL B 3  O ALA A 18 ? O ALA B 18 
AA1 5 6 N THR A 13 ? N THR B 13 O ILE B 14 ? O ILE C 30 
AA1 6 7 O PHE B 13 ? O PHE C 29 N LEU B 5  ? N LEU C 21 
AA1 7 8 N ILE B 6  ? N ILE C 22 O VAL B 44 ? O VAL C 60 
# 
_pdbx_entry_details.entry_id                   9LAF 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 HIS B 10 ? ? 51.40   -113.93 
2 1 ASP B 47 ? ? 46.45   -121.09 
3 1 ALA B 71 ? ? -153.64 73.84   
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    B 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     208 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   D 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 B ASP 82  ? A ASP 82  
2  1 Y 1 B ASP 83  ? A ASP 83  
3  1 Y 1 B THR 84  ? A THR 84  
4  1 Y 1 B PRO 96  ? A PRO 96  
5  1 Y 1 B PRO 97  ? A PRO 97  
6  1 Y 1 B GLU 98  ? A GLU 98  
7  1 Y 1 B LEU 99  ? A LEU 99  
8  1 Y 1 B PRO 100 ? A PRO 100 
9  1 Y 1 B ASP 101 ? A ASP 101 
10 1 Y 1 B VAL 102 ? A VAL 102 
11 1 Y 1 B MET 103 ? A MET 103 
12 1 Y 1 B LYS 104 ? A LYS 104 
13 1 Y 1 C GLY 48  ? B GLY 32  
14 1 Y 1 C PRO 49  ? B PRO 33  
15 1 Y 1 C GLY 50  ? B GLY 34  
16 1 Y 1 C GLN 51  ? B GLN 35  
17 1 Y 1 C PHE 52  ? B PHE 36  
18 1 Y 1 C ALA 53  ? B ALA 37  
19 1 Y 1 C GLU 54  ? B GLU 38  
20 1 Y 1 C ASN 55  ? B ASN 39  
21 1 Y 1 C SER 87  ? B SER 71  
22 1 Y 1 A MET 25  ? C MET 1   
23 1 Y 1 A HIS 26  ? C HIS 2   
24 1 Y 1 A HIS 27  ? C HIS 3   
25 1 Y 1 A HIS 28  ? C HIS 4   
26 1 Y 1 A HIS 29  ? C HIS 5   
27 1 Y 1 A HIS 30  ? C HIS 6   
28 1 Y 1 A HIS 31  ? C HIS 7   
29 1 Y 1 A GLY 32  ? C GLY 8   
30 1 Y 1 A SER 33  ? C SER 9   
31 1 Y 1 A GLU 34  ? C GLU 10  
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TYR N    N N N 321 
TYR CA   C N S 322 
TYR C    C N N 323 
TYR O    O N N 324 
TYR CB   C N N 325 
TYR CG   C Y N 326 
TYR CD1  C Y N 327 
TYR CD2  C Y N 328 
TYR CE1  C Y N 329 
TYR CE2  C Y N 330 
TYR CZ   C Y N 331 
TYR OH   O N N 332 
TYR OXT  O N N 333 
TYR H    H N N 334 
TYR H2   H N N 335 
TYR HA   H N N 336 
TYR HB2  H N N 337 
TYR HB3  H N N 338 
TYR HD1  H N N 339 
TYR HD2  H N N 340 
TYR HE1  H N N 341 
TYR HE2  H N N 342 
TYR HH   H N N 343 
TYR HXT  H N N 344 
VAL N    N N N 345 
VAL CA   C N S 346 
VAL C    C N N 347 
VAL O    O N N 348 
VAL CB   C N N 349 
VAL CG1  C N N 350 
VAL CG2  C N N 351 
VAL OXT  O N N 352 
VAL H    H N N 353 
VAL H2   H N N 354 
VAL HA   H N N 355 
VAL HB   H N N 356 
VAL HG11 H N N 357 
VAL HG12 H N N 358 
VAL HG13 H N N 359 
VAL HG21 H N N 360 
VAL HG22 H N N 361 
VAL HG23 H N N 362 
VAL HXT  H N N 363 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TYR N   CA   sing N N 306 
TYR N   H    sing N N 307 
TYR N   H2   sing N N 308 
TYR CA  C    sing N N 309 
TYR CA  CB   sing N N 310 
TYR CA  HA   sing N N 311 
TYR C   O    doub N N 312 
TYR C   OXT  sing N N 313 
TYR CB  CG   sing N N 314 
TYR CB  HB2  sing N N 315 
TYR CB  HB3  sing N N 316 
TYR CG  CD1  doub Y N 317 
TYR CG  CD2  sing Y N 318 
TYR CD1 CE1  sing Y N 319 
TYR CD1 HD1  sing N N 320 
TYR CD2 CE2  doub Y N 321 
TYR CD2 HD2  sing N N 322 
TYR CE1 CZ   doub Y N 323 
TYR CE1 HE1  sing N N 324 
TYR CE2 CZ   sing Y N 325 
TYR CE2 HE2  sing N N 326 
TYR CZ  OH   sing N N 327 
TYR OH  HH   sing N N 328 
TYR OXT HXT  sing N N 329 
VAL N   CA   sing N N 330 
VAL N   H    sing N N 331 
VAL N   H2   sing N N 332 
VAL CA  C    sing N N 333 
VAL CA  CB   sing N N 334 
VAL CA  HA   sing N N 335 
VAL C   O    doub N N 336 
VAL C   OXT  sing N N 337 
VAL CB  CG1  sing N N 338 
VAL CB  CG2  sing N N 339 
VAL CB  HB   sing N N 340 
VAL CG1 HG11 sing N N 341 
VAL CG1 HG12 sing N N 342 
VAL CG1 HG13 sing N N 343 
VAL CG2 HG21 sing N N 344 
VAL CG2 HG22 sing N N 345 
VAL CG2 HG23 sing N N 346 
VAL OXT HXT  sing N N 347 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Other government'                          ?                    2310200          1 
'Other government'                          ?                    2510731          2 
'National Research Foundation (NRF, Korea)' 'Korea, Republic Of' RS-2023-NR076355 3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   3DCG 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9LAF 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.008323 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.006385 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.027161 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . MET A 1 1  ? -0.07912  -19.88036 5.51746   1.000 49.48927 ? 1   MET B N   1 
ATOM   2    C CA  . MET A 1 1  ? -1.27840  -20.36417 6.19015   1.000 43.89345 ? 1   MET B CA  1 
ATOM   3    C C   . MET A 1 1  ? -2.50968  -20.21530 5.30262   1.000 41.66209 ? 1   MET B C   1 
ATOM   4    O O   . MET A 1 1  ? -2.79932  -19.12035 4.80959   1.000 39.25820 ? 1   MET B O   1 
ATOM   5    C CB  . MET A 1 1  ? -1.49519  -19.61549 7.50274   1.000 45.01509 ? 1   MET B CB  1 
ATOM   6    C CG  . MET A 1 1  ? -2.73059  -20.08639 8.25305   1.000 50.76276 ? 1   MET B CG  1 
ATOM   7    S SD  . MET A 1 1  ? -2.81822  -21.88075 8.48834   1.000 67.10454 ? 1   MET B SD  1 
ATOM   8    C CE  . MET A 1 1  ? -4.58738  -22.14746 8.66264   1.000 53.95765 ? 1   MET B CE  1 
ATOM   9    N N   . ASP A 1 2  ? -3.24204  -21.31312 5.13158   1.000 37.46156 ? 2   ASP B N   1 
ATOM   10   C CA  . ASP A 1 2  ? -4.37011  -21.33636 4.21078   1.000 34.40010 ? 2   ASP B CA  1 
ATOM   11   C C   . ASP A 1 2  ? -5.58508  -20.60939 4.78189   1.000 34.29985 ? 2   ASP B C   1 
ATOM   12   O O   . ASP A 1 2  ? -5.89693  -20.72666 5.96886   1.000 33.76486 ? 2   ASP B O   1 
ATOM   13   C CB  . ASP A 1 2  ? -4.73621  -22.78112 3.87907   1.000 33.65216 ? 2   ASP B CB  1 
ATOM   14   C CG  . ASP A 1 2  ? -3.69451  -23.45862 3.00036   1.000 42.38103 ? 2   ASP B CG  1 
ATOM   15   O OD1 . ASP A 1 2  ? -3.24502  -22.83777 2.00808   1.000 45.00255 ? 2   ASP B OD1 1 
ATOM   16   O OD2 . ASP A 1 2  ? -3.32181  -24.61034 3.29920   1.000 43.72938 ? 2   ASP B OD2 1 
ATOM   17   N N   . VAL A 1 3  ? -6.27149  -19.84672 3.91959   1.000 26.26027 ? 3   VAL B N   1 
ATOM   18   C CA  . VAL A 1 3  ? -7.59217  -19.29417 4.21407   1.000 25.37431 ? 3   VAL B CA  1 
ATOM   19   C C   . VAL A 1 3  ? -8.60165  -19.96696 3.29094   1.000 24.37825 ? 3   VAL B C   1 
ATOM   20   O O   . VAL A 1 3  ? -8.28173  -20.33558 2.15475   1.000 23.06134 ? 3   VAL B O   1 
ATOM   21   C CB  . VAL A 1 3  ? -7.64889  -17.75526 4.06165   1.000 29.71722 ? 3   VAL B CB  1 
ATOM   22   C CG1 . VAL A 1 3  ? -6.74076  -17.08445 5.08707   1.000 29.49864 ? 3   VAL B CG1 1 
ATOM   23   C CG2 . VAL A 1 3  ? -7.29430  -17.32062 2.62722   1.000 23.27642 ? 3   VAL B CG2 1 
ATOM   24   N N   . PHE A 1 4  ? -9.82691  -20.13585 3.78683   1.000 20.05594 ? 4   PHE B N   1 
ATOM   25   C CA  . PHE A 1 4  ? -10.86034 -20.88201 3.08067   1.000 19.52826 ? 4   PHE B CA  1 
ATOM   26   C C   . PHE A 1 4  ? -12.02342 -19.95634 2.75556   1.000 20.35513 ? 4   PHE B C   1 
ATOM   27   O O   . PHE A 1 4  ? -12.51097 -19.22780 3.62816   1.000 18.01146 ? 4   PHE B O   1 
ATOM   28   C CB  . PHE A 1 4  ? -11.28822 -22.09376 3.91044   1.000 18.28184 ? 4   PHE B CB  1 
ATOM   29   C CG  . PHE A 1 4  ? -10.15320 -23.04739 4.14316   1.000 22.73318 ? 4   PHE B CG  1 
ATOM   30   C CD1 . PHE A 1 4  ? -9.32153  -22.89896 5.24592   1.000 21.87623 ? 4   PHE B CD1 1 
ATOM   31   C CD2 . PHE A 1 4  ? -9.86304  -24.03151 3.21325   1.000 21.05827 ? 4   PHE B CD2 1 
ATOM   32   C CE1 . PHE A 1 4  ? -8.25174  -23.73983 5.44367   1.000 22.06950 ? 4   PHE B CE1 1 
ATOM   33   C CE2 . PHE A 1 4  ? -8.78927  -24.88593 3.40529   1.000 24.15355 ? 4   PHE B CE2 1 
ATOM   34   C CZ  . PHE A 1 4  ? -7.98332  -24.73830 4.52484   1.000 24.31247 ? 4   PHE B CZ  1 
ATOM   35   N N   . LEU A 1 5  ? -12.45016 -19.97515 1.49177   1.000 19.04965 ? 5   LEU B N   1 
ATOM   36   C CA  . LEU A 1 5  ? -13.26926 -18.91243 0.93480   1.000 15.90893 ? 5   LEU B CA  1 
ATOM   37   C C   . LEU A 1 5  ? -14.45868 -19.47453 0.16653   1.000 17.39477 ? 5   LEU B C   1 
ATOM   38   O O   . LEU A 1 5  ? -14.42240 -20.59476 -0.35604  1.000 15.55406 ? 5   LEU B O   1 
ATOM   39   C CB  . LEU A 1 5  ? -12.44155 -18.03139 -0.01687  1.000 16.97599 ? 5   LEU B CB  1 
ATOM   40   C CG  . LEU A 1 5  ? -11.09107 -17.47786 0.46904   1.000 21.45877 ? 5   LEU B CG  1 
ATOM   41   C CD1 . LEU A 1 5  ? -10.40392 -16.75975 -0.68664  1.000 18.15448 ? 5   LEU B CD1 1 
ATOM   42   C CD2 . LEU A 1 5  ? -11.30828 -16.53371 1.63662   1.000 18.58033 ? 5   LEU B CD2 1 
ATOM   43   N N   . MET A 1 6  ? -15.50385 -18.66114 0.08890   1.000 13.16617 ? 6   MET B N   1 
ATOM   44   C CA  . MET A 1 6  ? -16.57199 -18.80520 -0.89428  1.000 17.30191 ? 6   MET B CA  1 
ATOM   45   C C   . MET A 1 6  ? -16.58057 -17.53610 -1.72990  1.000 15.92571 ? 6   MET B C   1 
ATOM   46   O O   . MET A 1 6  ? -16.83276 -16.44927 -1.19929  1.000 17.65471 ? 6   MET B O   1 
ATOM   47   C CB  . MET A 1 6  ? -17.94656 -18.98932 -0.22965  1.000 18.57581 ? 6   MET B CB  1 
ATOM   48   C CG  . MET A 1 6  ? -18.17990 -20.32400 0.46196   1.000 19.11464 ? 6   MET B CG  1 
ATOM   49   S SD  . MET A 1 6  ? -19.90263 -20.48287 1.04163   1.000 22.83003 ? 6   MET B SD  1 
ATOM   50   C CE  . MET A 1 6  ? -19.95077 -19.29043 2.38705   1.000 14.42726 ? 6   MET B CE  1 
ATOM   51   N N   . ILE A 1 7  ? -16.31760 -17.66300 -3.02298  1.000 14.91336 ? 7   ILE B N   1 
ATOM   52   C CA  . ILE A 1 7  ? -16.39266 -16.53172 -3.94267  1.000 16.43534 ? 7   ILE B CA  1 
ATOM   53   C C   . ILE A 1 7  ? -17.75742 -16.56703 -4.62812  1.000 15.39761 ? 7   ILE B C   1 
ATOM   54   O O   . ILE A 1 7  ? -18.07395 -17.51711 -5.34821  1.000 16.45133 ? 7   ILE B O   1 
ATOM   55   C CB  . ILE A 1 7  ? -15.23442 -16.56712 -4.95563  1.000 15.49740 ? 7   ILE B CB  1 
ATOM   56   C CG1 . ILE A 1 7  ? -13.89296 -16.61368 -4.19418  1.000 20.04536 ? 7   ILE B CG1 1 
ATOM   57   C CG2 . ILE A 1 7  ? -15.30467 -15.34936 -5.87350  1.000 13.80198 ? 7   ILE B CG2 1 
ATOM   58   C CD1 . ILE A 1 7  ? -12.67919 -16.87544 -5.04783  1.000 23.20629 ? 7   ILE B CD1 1 
ATOM   59   N N   . ARG A 1 8  ? -18.57324 -15.53950 -4.41742  1.000 14.98029 ? 8   ARG B N   1 
ATOM   60   C CA  . ARG A 1 8  ? -19.99512 -15.61749 -4.73413  1.000 16.26142 ? 8   ARG B CA  1 
ATOM   61   C C   . ARG A 1 8  ? -20.41102 -14.49032 -5.66869  1.000 17.61248 ? 8   ARG B C   1 
ATOM   62   O O   . ARG A 1 8  ? -20.08791 -13.32119 -5.43041  1.000 16.89961 ? 8   ARG B O   1 
ATOM   63   C CB  . ARG A 1 8  ? -20.83678 -15.58995 -3.44839  1.000 16.38084 ? 8   ARG B CB  1 
ATOM   64   C CG  . ARG A 1 8  ? -20.45089 -16.71032 -2.45635  1.000 16.91506 ? 8   ARG B CG  1 
ATOM   65   C CD  . ARG A 1 8  ? -21.52808 -16.93904 -1.42162  1.000 15.94702 ? 8   ARG B CD  1 
ATOM   66   N NE  . ARG A 1 8  ? -22.80808 -17.24354 -2.04864  1.000 16.57255 ? 8   ARG B NE  1 
ATOM   67   C CZ  . ARG A 1 8  ? -23.97912 -16.97803 -1.48736  1.000 17.81132 ? 8   ARG B CZ  1 
ATOM   68   N NH1 . ARG A 1 8  ? -24.05855 -16.43368 -0.28489  1.000 17.58885 ? 8   ARG B NH1 1 
ATOM   69   N NH2 . ARG A 1 8  ? -25.09452 -17.23514 -2.16135  1.000 18.79986 ? 8   ARG B NH2 1 
ATOM   70   N N   . ARG A 1 9  ? -21.12401 -14.85450 -6.73198  1.000 15.38839 ? 9   ARG B N   1 
ATOM   71   C CA  . ARG A 1 9  ? -21.74664 -13.90987 -7.65021  1.000 18.35957 ? 9   ARG B CA  1 
ATOM   72   C C   . ARG A 1 9  ? -23.06147 -14.51143 -8.11742  1.000 19.81894 ? 9   ARG B C   1 
ATOM   73   O O   . ARG A 1 9  ? -23.07497 -15.65638 -8.58342  1.000 17.80002 ? 9   ARG B O   1 
ATOM   74   C CB  . ARG A 1 9  ? -20.85059 -13.63392 -8.85657  1.000 17.15367 ? 9   ARG B CB  1 
ATOM   75   C CG  . ARG A 1 9  ? -21.59307 -12.97203 -10.00387 1.000 18.55235 ? 9   ARG B CG  1 
ATOM   76   C CD  . ARG A 1 9  ? -20.73168 -12.90015 -11.25618 1.000 21.26060 ? 9   ARG B CD  1 
ATOM   77   N NE  . ARG A 1 9  ? -21.41909 -12.18471 -12.32439 1.000 23.22896 ? 9   ARG B NE  1 
ATOM   78   C CZ  . ARG A 1 9  ? -22.22466 -12.75883 -13.20770 1.000 26.72228 ? 9   ARG B CZ  1 
ATOM   79   N NH1 . ARG A 1 9  ? -22.42301 -14.06673 -13.21423 1.000 23.51977 ? 9   ARG B NH1 1 
ATOM   80   N NH2 . ARG A 1 9  ? -22.85427 -12.00105 -14.10065 1.000 25.77670 ? 9   ARG B NH2 1 
ATOM   81   N N   . HIS A 1 10 ? -24.14478 -13.73901 -8.01699  1.000 16.39002 ? 10  HIS B N   1 
ATOM   82   C CA  . HIS A 1 10 ? -25.46963 -14.19295 -8.42625  1.000 19.56042 ? 10  HIS B CA  1 
ATOM   83   C C   . HIS A 1 10 ? -25.79288 -15.53581 -7.78526  1.000 18.92567 ? 10  HIS B C   1 
ATOM   84   O O   . HIS A 1 10 ? -25.89743 -15.63413 -6.55773  1.000 19.48870 ? 10  HIS B O   1 
ATOM   85   C CB  . HIS A 1 10 ? -25.57037 -14.28381 -9.95331  1.000 19.07204 ? 10  HIS B CB  1 
ATOM   86   C CG  . HIS A 1 10 ? -25.51671 -12.95132 -10.63547 1.000 23.14396 ? 10  HIS B CG  1 
ATOM   87   N ND1 . HIS A 1 10 ? -25.75322 -12.79306 -11.98385 1.000 27.67822 ? 10  HIS B ND1 1 
ATOM   88   C CD2 . HIS A 1 10 ? -25.23404 -11.71529 -10.15723 1.000 23.05537 ? 10  HIS B CD2 1 
ATOM   89   C CE1 . HIS A 1 10 ? -25.62077 -11.51912 -12.30832 1.000 24.32041 ? 10  HIS B CE1 1 
ATOM   90   N NE2 . HIS A 1 10 ? -25.31070 -10.84333 -11.21713 1.000 25.23639 ? 10  HIS B NE2 1 
ATOM   91   N N   . LYS A 1 11 ? -25.91069 -16.57836 -8.60310  1.000 18.71074 ? 11  LYS B N   1 
ATOM   92   C CA  . LYS A 1 11 ? -26.15747 -17.92855 -8.11659  1.000 20.84772 ? 11  LYS B CA  1 
ATOM   93   C C   . LYS A 1 11 ? -24.95871 -18.84934 -8.33147  1.000 22.43377 ? 11  LYS B C   1 
ATOM   94   O O   . LYS A 1 11 ? -25.12153 -20.06558 -8.45593  1.000 21.05298 ? 11  LYS B O   1 
ATOM   95   C CB  . LYS A 1 11 ? -27.40336 -18.50426 -8.78385  1.000 22.04826 ? 11  LYS B CB  1 
ATOM   96   C CG  . LYS A 1 11 ? -28.70616 -17.95027 -8.22008  1.000 22.11171 ? 11  LYS B CG  1 
ATOM   97   C CD  . LYS A 1 11 ? -29.88609 -18.58949 -8.92975  1.000 25.71148 ? 11  LYS B CD  1 
ATOM   98   C CE  . LYS A 1 11 ? -30.89084 -19.13211 -7.95175  1.000 25.76130 ? 11  LYS B CE  1 
ATOM   99   N NZ  . LYS A 1 11 ? -32.00167 -19.81022 -8.69341  1.000 32.85963 ? 11  LYS B NZ  1 
ATOM   100  N N   . THR A 1 12 ? -23.75373 -18.28132 -8.39105  1.000 17.81762 ? 12  THR B N   1 
ATOM   101  C CA  . THR A 1 12 ? -22.51413 -19.04040 -8.46624  1.000 17.48525 ? 12  THR B CA  1 
ATOM   102  C C   . THR A 1 12 ? -21.76747 -18.90278 -7.14822  1.000 18.16012 ? 12  THR B C   1 
ATOM   103  O O   . THR A 1 12 ? -21.66176 -17.79977 -6.60338  1.000 18.30289 ? 12  THR B O   1 
ATOM   104  C CB  . THR A 1 12 ? -21.62219 -18.54573 -9.61204  1.000 22.28002 ? 12  THR B CB  1 
ATOM   105  O OG1 . THR A 1 12 ? -22.29709 -18.73101 -10.86392 1.000 22.09329 ? 12  THR B OG1 1 
ATOM   106  C CG2 . THR A 1 12 ? -20.27151 -19.30692 -9.62757  1.000 17.28992 ? 12  THR B CG2 1 
ATOM   107  N N   . THR A 1 13 ? -21.25288 -20.02043 -6.63521  1.000 14.64852 ? 13  THR B N   1 
ATOM   108  C CA  . THR A 1 13 ? -20.41864 -20.02219 -5.43389  1.000 14.89046 ? 13  THR B CA  1 
ATOM   109  C C   . THR A 1 13 ? -19.22150 -20.92798 -5.68055  1.000 19.56990 ? 13  THR B C   1 
ATOM   110  O O   . THR A 1 13 ? -19.39035 -22.13145 -5.90615  1.000 17.83389 ? 13  THR B O   1 
ATOM   111  C CB  . THR A 1 13 ? -21.20624 -20.50572 -4.20900  1.000 16.21485 ? 13  THR B CB  1 
ATOM   112  O OG1 . THR A 1 13 ? -22.25999 -19.57847 -3.91166  1.000 16.18284 ? 13  THR B OG1 1 
ATOM   113  C CG2 . THR A 1 13 ? -20.29249 -20.67234 -2.98481  1.000 15.26572 ? 13  THR B CG2 1 
ATOM   114  N N   . ILE A 1 14 ? -18.01854 -20.35504 -5.66624  1.000 16.97158 ? 14  ILE B N   1 
ATOM   115  C CA  . ILE A 1 14 ? -16.78301 -21.11828 -5.80647  1.000 14.82388 ? 14  ILE B CA  1 
ATOM   116  C C   . ILE A 1 14 ? -16.21642 -21.36609 -4.41590  1.000 16.53947 ? 14  ILE B C   1 
ATOM   117  O O   . ILE A 1 14 ? -15.96962 -20.41404 -3.66236  1.000 18.27026 ? 14  ILE B O   1 
ATOM   118  C CB  . ILE A 1 14 ? -15.75510 -20.37524 -6.67559  1.000 16.21466 ? 14  ILE B CB  1 
ATOM   119  C CG1 . ILE A 1 14 ? -16.27496 -20.16191 -8.10431  1.000 16.47275 ? 14  ILE B CG1 1 
ATOM   120  C CG2 . ILE A 1 14 ? -14.41828 -21.12403 -6.66803  1.000 15.64431 ? 14  ILE B CG2 1 
ATOM   121  C CD1 . ILE A 1 14 ? -15.44158 -19.15190 -8.90164  1.000 14.23885 ? 14  ILE B CD1 1 
ATOM   122  N N   . PHE A 1 15 ? -15.99459 -22.63490 -4.07646  1.000 16.61336 ? 15  PHE B N   1 
ATOM   123  C CA  . PHE A 1 15 ? -15.26397 -23.00554 -2.86662  1.000 18.75081 ? 15  PHE B CA  1 
ATOM   124  C C   . PHE A 1 15 ? -13.78963 -23.15215 -3.22635  1.000 21.46017 ? 15  PHE B C   1 
ATOM   125  O O   . PHE A 1 15 ? -13.43552 -23.97143 -4.07743  1.000 20.93953 ? 15  PHE B O   1 
ATOM   126  C CB  . PHE A 1 15 ? -15.79979 -24.30792 -2.26758  1.000 17.60001 ? 15  PHE B CB  1 
ATOM   127  C CG  . PHE A 1 15 ? -17.05453 -24.13101 -1.43462  1.000 17.92665 ? 15  PHE B CG  1 
ATOM   128  C CD1 . PHE A 1 15 ? -18.30296 -24.02229 -2.04079  1.000 16.51753 ? 15  PHE B CD1 1 
ATOM   129  C CD2 . PHE A 1 15 ? -16.98365 -24.11233 -0.04594  1.000 17.03490 ? 15  PHE B CD2 1 
ATOM   130  C CE1 . PHE A 1 15 ? -19.46497 -23.85748 -1.27177  1.000 16.50413 ? 15  PHE B CE1 1 
ATOM   131  C CE2 . PHE A 1 15 ? -18.13629 -23.95461 0.73650   1.000 16.81530 ? 15  PHE B CE2 1 
ATOM   132  C CZ  . PHE A 1 15 ? -19.37610 -23.82564 0.12854   1.000 15.71590 ? 15  PHE B CZ  1 
ATOM   133  N N   . THR A 1 16 ? -12.93411 -22.35436 -2.59815  1.000 19.57773 ? 16  THR B N   1 
ATOM   134  C CA  . THR A 1 16 ? -11.51174 -22.42930 -2.88788  1.000 20.06015 ? 16  THR B CA  1 
ATOM   135  C C   . THR A 1 16 ? -10.74782 -21.95288 -1.66238  1.000 21.50503 ? 16  THR B C   1 
ATOM   136  O O   . THR A 1 16 ? -11.31458 -21.36653 -0.73478  1.000 21.45572 ? 16  THR B O   1 
ATOM   137  C CB  . THR A 1 16 ? -11.15327 -21.60658 -4.14419  1.000 24.22852 ? 16  THR B CB  1 
ATOM   138  O OG1 . THR A 1 16 ? -9.84509  -21.96298 -4.60545  1.000 28.30891 ? 16  THR B OG1 1 
ATOM   139  C CG2 . THR A 1 16 ? -11.18305 -20.10761 -3.85172  1.000 22.13082 ? 16  THR B CG2 1 
ATOM   140  N N   . ASP A 1 17 ? -9.44921  -22.21799 -1.66277  1.000 21.41054 ? 17  ASP B N   1 
ATOM   141  C CA  . ASP A 1 17 ? -8.56760  -21.78120 -0.59500  1.000 23.86146 ? 17  ASP B CA  1 
ATOM   142  C C   . ASP A 1 17 ? -7.34306  -21.09678 -1.19235  1.000 25.40586 ? 17  ASP B C   1 
ATOM   143  O O   . ASP A 1 17 ? -7.04408  -21.23604 -2.37751  1.000 24.49900 ? 17  ASP B O   1 
ATOM   144  C CB  . ASP A 1 17 ? -8.12964  -22.94794 0.28804   1.000 23.86835 ? 17  ASP B CB  1 
ATOM   145  C CG  . ASP A 1 17 ? -7.60256  -24.11413 -0.51818  1.000 28.46802 ? 17  ASP B CG  1 
ATOM   146  O OD1 . ASP A 1 17 ? -8.41474  -24.99028 -0.91718  1.000 33.38052 ? 17  ASP B OD1 1 
ATOM   147  O OD2 . ASP A 1 17 ? -6.38298  -24.13273 -0.77488  1.000 31.55524 ? 17  ASP B OD2 1 
ATOM   148  N N   . ALA A 1 18 ? -6.63492  -20.35731 -0.34835  1.000 23.11997 ? 18  ALA B N   1 
ATOM   149  C CA  . ALA A 1 18 ? -5.41021  -19.68119 -0.74773  1.000 25.70742 ? 18  ALA B CA  1 
ATOM   150  C C   . ALA A 1 18 ? -4.61809  -19.38176 0.51450   1.000 29.51133 ? 18  ALA B C   1 
ATOM   151  O O   . ALA A 1 18 ? -5.12251  -19.50791 1.63123   1.000 26.60084 ? 18  ALA B O   1 
ATOM   152  C CB  . ALA A 1 18 ? -5.70450  -18.39452 -1.53214  1.000 26.30830 ? 18  ALA B CB  1 
ATOM   153  N N   . LYS A 1 19 ? -3.36904  -18.97674 0.32952   1.000 33.32215 ? 19  LYS B N   1 
ATOM   154  C CA  . LYS A 1 19 ? -2.56817  -18.58657 1.47827   1.000 29.50995 ? 19  LYS B CA  1 
ATOM   155  C C   . LYS A 1 19 ? -2.95055  -17.18631 1.92489   1.000 26.45770 ? 19  LYS B C   1 
ATOM   156  O O   . LYS A 1 19 ? -3.33456  -16.33673 1.11842   1.000 27.61543 ? 19  LYS B O   1 
ATOM   157  C CB  . LYS A 1 19 ? -1.07550  -18.67307 1.15362   1.000 28.04947 ? 19  LYS B CB  1 
ATOM   158  C CG  . LYS A 1 19 ? -0.60348  -20.11645 0.99024   1.000 32.48919 ? 19  LYS B CG  1 
ATOM   159  C CD  . LYS A 1 19 ? 0.53802   -20.23623 0.00136   1.000 40.35659 ? 19  LYS B CD  1 
ATOM   160  C CE  . LYS A 1 19 ? 0.47190   -21.56392 -0.74385  1.000 48.87991 ? 19  LYS B CE  1 
ATOM   161  N NZ  . LYS A 1 19 ? 1.09588   -21.48602 -2.10471  1.000 54.09243 ? 19  LYS B NZ  1 
ATOM   162  N N   . GLU A 1 20 ? -2.86337  -16.95691 3.23721   1.000 28.72461 ? 20  GLU B N   1 
ATOM   163  C CA  . GLU A 1 20 ? -3.12211  -15.63247 3.79018   1.000 27.26291 ? 20  GLU B CA  1 
ATOM   164  C C   . GLU A 1 20 ? -2.19960  -14.56862 3.19528   1.000 28.36737 ? 20  GLU B C   1 
ATOM   165  O O   . GLU A 1 20 ? -2.57526  -13.39066 3.13782   1.000 26.77358 ? 20  GLU B O   1 
ATOM   166  C CB  . GLU A 1 20 ? -2.96996  -15.69355 5.31672   1.000 33.20624 ? 20  GLU B CB  1 
ATOM   167  C CG  . GLU A 1 20 ? -3.65440  -14.58442 6.05997   1.000 30.75008 ? 20  GLU B CG  1 
ATOM   168  C CD  . GLU A 1 20 ? -3.60078  -14.77024 7.56694   1.000 39.08257 ? 20  GLU B CD  1 
ATOM   169  O OE1 . GLU A 1 20 ? -3.97873  -15.85305 8.06917   1.000 46.98108 ? 20  GLU B OE1 1 
ATOM   170  O OE2 . GLU A 1 20 ? -3.17107  -13.82602 8.25590   1.000 41.69532 ? 20  GLU B OE2 1 
ATOM   171  N N   . SER A 1 21 ? -1.00892  -14.95849 2.73582   1.000 25.94137 ? 21  SER B N   1 
ATOM   172  C CA  . SER A 1 21 ? -0.06741  -14.03397 2.11729   1.000 27.48091 ? 21  SER B CA  1 
ATOM   173  C C   . SER A 1 21 ? -0.23225  -13.91253 0.60291   1.000 26.76400 ? 21  SER B C   1 
ATOM   174  O O   . SER A 1 21 ? 0.51031   -13.15026 -0.02472  1.000 24.97411 ? 21  SER B O   1 
ATOM   175  C CB  . SER A 1 21 ? 1.36651   -14.46367 2.44080   1.000 28.19625 ? 21  SER B CB  1 
ATOM   176  O OG  . SER A 1 21 ? 1.58809   -15.81340 2.04384   1.000 27.67202 ? 21  SER B OG  1 
ATOM   177  N N   . SER A 1 22 ? -1.16015  -14.64172 -0.01315  1.000 24.09543 ? 22  SER B N   1 
ATOM   178  C CA  . SER A 1 22 ? -1.39533  -14.41090 -1.43403  1.000 24.15792 ? 22  SER B CA  1 
ATOM   179  C C   . SER A 1 22 ? -2.14143  -13.09104 -1.61894  1.000 21.15264 ? 22  SER B C   1 
ATOM   180  O O   . SER A 1 22 ? -2.68354  -12.53131 -0.66978  1.000 22.89814 ? 22  SER B O   1 
ATOM   181  C CB  . SER A 1 22 ? -2.16723  -15.58133 -2.05610  1.000 27.56885 ? 22  SER B CB  1 
ATOM   182  O OG  . SER A 1 22 ? -3.40723  -15.79728 -1.40509  1.000 24.24175 ? 22  SER B OG  1 
ATOM   183  N N   . THR A 1 23 ? -2.15209  -12.57357 -2.84904  1.000 19.32888 ? 23  THR B N   1 
ATOM   184  C CA  . THR A 1 23 ? -2.74706  -11.26580 -3.09414  1.000 21.13861 ? 23  THR B CA  1 
ATOM   185  C C   . THR A 1 23 ? -4.11312  -11.37989 -3.76495  1.000 23.00312 ? 23  THR B C   1 
ATOM   186  O O   . THR A 1 23 ? -4.50086  -12.42775 -4.29296  1.000 18.91258 ? 23  THR B O   1 
ATOM   187  C CB  . THR A 1 23 ? -1.83429  -10.38039 -3.94842  1.000 20.93942 ? 23  THR B CB  1 
ATOM   188  O OG1 . THR A 1 23 ? -1.76141  -10.89766 -5.28497  1.000 19.96403 ? 23  THR B OG1 1 
ATOM   189  C CG2 . THR A 1 23 ? -0.42931  -10.29572 -3.33592  1.000 22.90230 ? 23  THR B CG2 1 
ATOM   190  N N   . VAL A 1 24 ? -4.84745  -10.25769 -3.72337  1.000 19.75664 ? 24  VAL B N   1 
ATOM   191  C CA  . VAL A 1 24 ? -6.15615  -10.17019 -4.36894  1.000 19.02424 ? 24  VAL B CA  1 
ATOM   192  C C   . VAL A 1 24 ? -6.04532  -10.51634 -5.85219  1.000 20.72279 ? 24  VAL B C   1 
ATOM   193  O O   . VAL A 1 24 ? -6.89916  -11.22366 -6.40504  1.000 17.46349 ? 24  VAL B O   1 
ATOM   194  C CB  . VAL A 1 24 ? -6.75900  -8.76722  -4.15401  1.000 18.74142 ? 24  VAL B CB  1 
ATOM   195  C CG1 . VAL A 1 24 ? -7.92277  -8.52296  -5.10741  1.000 18.81746 ? 24  VAL B CG1 1 
ATOM   196  C CG2 . VAL A 1 24 ? -7.18786  -8.57427  -2.69555  1.000 18.75776 ? 24  VAL B CG2 1 
ATOM   197  N N   . PHE A 1 25 ? -4.98894  -10.03130 -6.51610  1.000 16.88479 ? 25  PHE B N   1 
ATOM   198  C CA  . PHE A 1 25 ? -4.77663  -10.34974 -7.92794  1.000 17.98331 ? 25  PHE B CA  1 
ATOM   199  C C   . PHE A 1 25 ? -4.61913  -11.85006 -8.15198  1.000 19.11740 ? 25  PHE B C   1 
ATOM   200  O O   . PHE A 1 25 ? -5.12682  -12.39271 -9.14084  1.000 17.87961 ? 25  PHE B O   1 
ATOM   201  C CB  . PHE A 1 25 ? -3.54395  -9.61864  -8.45759  1.000 19.90940 ? 25  PHE B CB  1 
ATOM   202  C CG  . PHE A 1 25 ? -3.19219  -9.97625  -9.88331  1.000 18.89433 ? 25  PHE B CG  1 
ATOM   203  C CD1 . PHE A 1 25 ? -3.81878  -9.33709  -10.94525 1.000 18.18234 ? 25  PHE B CD1 1 
ATOM   204  C CD2 . PHE A 1 25 ? -2.23199  -10.93781 -10.15785 1.000 19.71690 ? 25  PHE B CD2 1 
ATOM   205  C CE1 . PHE A 1 25 ? -3.49926  -9.65202  -12.26368 1.000 21.58047 ? 25  PHE B CE1 1 
ATOM   206  C CE2 . PHE A 1 25 ? -1.91092  -11.26841 -11.47718 1.000 22.58322 ? 25  PHE B CE2 1 
ATOM   207  C CZ  . PHE A 1 25 ? -2.54748  -10.62426 -12.52871 1.000 20.71517 ? 25  PHE B CZ  1 
ATOM   208  N N   . GLU A 1 26 ? -3.88215  -12.52908 -7.26836  1.000 20.02229 ? 26  GLU B N   1 
ATOM   209  C CA  . GLU A 1 26 ? -3.69217  -13.96741 -7.41811  1.000 21.53077 ? 26  GLU B CA  1 
ATOM   210  C C   . GLU A 1 26 ? -5.01118  -14.71024 -7.24480  1.000 20.18693 ? 26  GLU B C   1 
ATOM   211  O O   . GLU A 1 26 ? -5.25970  -15.71596 -7.92079  1.000 20.40726 ? 26  GLU B O   1 
ATOM   212  C CB  . GLU A 1 26 ? -2.63589  -14.46220 -6.42251  1.000 19.29627 ? 26  GLU B CB  1 
ATOM   213  C CG  . GLU A 1 26 ? -1.21435  -14.10358 -6.85071  1.000 23.18473 ? 26  GLU B CG  1 
ATOM   214  C CD  . GLU A 1 26 ? -0.15001  -14.39317 -5.79270  1.000 26.66556 ? 26  GLU B CD  1 
ATOM   215  O OE1 . GLU A 1 26 ? -0.38737  -14.12894 -4.58859  1.000 24.89507 ? 26  GLU B OE1 1 
ATOM   216  O OE2 . GLU A 1 26 ? 0.93982   -14.87246 -6.17820  1.000 25.75742 ? 26  GLU B OE2 1 
ATOM   217  N N   . LEU A 1 27 ? -5.88207  -14.21178 -6.36537  1.000 20.39886 ? 27  LEU B N   1 
ATOM   218  C CA  . LEU A 1 27 ? -7.21565  -14.79635 -6.23174  1.000 19.63813 ? 27  LEU B CA  1 
ATOM   219  C C   . LEU A 1 27 ? -8.04616  -14.57613 -7.49556  1.000 16.75299 ? 27  LEU B C   1 
ATOM   220  O O   . LEU A 1 27 ? -8.76606  -15.48049 -7.93617  1.000 18.31059 ? 27  LEU B O   1 
ATOM   221  C CB  . LEU A 1 27 ? -7.92386  -14.22460 -5.00206  1.000 18.59557 ? 27  LEU B CB  1 
ATOM   222  C CG  . LEU A 1 27 ? -9.24195  -14.90983 -4.58462  1.000 23.39958 ? 27  LEU B CG  1 
ATOM   223  C CD1 . LEU A 1 27 ? -9.01555  -16.38681 -4.28496  1.000 21.13980 ? 27  LEU B CD1 1 
ATOM   224  C CD2 . LEU A 1 27 ? -9.90407  -14.21663 -3.38565  1.000 17.43823 ? 27  LEU B CD2 1 
ATOM   225  N N   . LYS A 1 28 ? -7.94254  -13.39658 -8.11203  1.000 16.13481 ? 28  LYS B N   1 
ATOM   226  C CA  . LYS A 1 28 ? -8.61062  -13.17240 -9.39774  1.000 17.33610 ? 28  LYS B CA  1 
ATOM   227  C C   . LYS A 1 28 ? -8.08673  -14.11462 -10.47365 1.000 18.44714 ? 28  LYS B C   1 
ATOM   228  O O   . LYS A 1 28 ? -8.84558  -14.54064 -11.35374 1.000 18.79739 ? 28  LYS B O   1 
ATOM   229  C CB  . LYS A 1 28 ? -8.42401  -11.72563 -9.86578  1.000 15.35480 ? 28  LYS B CB  1 
ATOM   230  C CG  . LYS A 1 28 ? -9.12661  -10.69648 -9.01449  1.000 17.82480 ? 28  LYS B CG  1 
ATOM   231  C CD  . LYS A 1 28 ? -8.81254  -9.26092  -9.49540  1.000 17.75433 ? 28  LYS B CD  1 
ATOM   232  C CE  . LYS A 1 28 ? -9.73535  -8.25890  -8.81894  1.000 20.02225 ? 28  LYS B CE  1 
ATOM   233  N NZ  . LYS A 1 28 ? -9.51922  -6.87753  -9.33382  1.000 24.93340 ? 28  LYS B NZ  1 
ATOM   234  N N   . ARG A 1 29 ? -6.79938  -14.45179 -10.41805 1.000 17.22907 ? 29  ARG B N   1 
ATOM   235  C CA  . ARG A 1 29 ? -6.25158  -15.43605 -11.34926 1.000 21.98643 ? 29  ARG B CA  1 
ATOM   236  C C   . ARG A 1 29 ? -6.90665  -16.80802 -11.15850 1.000 20.89725 ? 29  ARG B C   1 
ATOM   237  O O   . ARG A 1 29 ? -7.11028  -17.54596 -12.12753 1.000 21.04854 ? 29  ARG B O   1 
ATOM   238  C CB  . ARG A 1 29 ? -4.73188  -15.51093 -11.16414 1.000 20.46288 ? 29  ARG B CB  1 
ATOM   239  C CG  . ARG A 1 29 ? -3.99027  -16.12454 -12.30183 1.000 26.77757 ? 29  ARG B CG  1 
ATOM   240  C CD  . ARG A 1 29 ? -4.23256  -15.30881 -13.56460 1.000 31.89649 ? 29  ARG B CD  1 
ATOM   241  N NE  . ARG A 1 29 ? -3.10855  -14.45549 -13.92882 1.000 24.70142 ? 29  ARG B NE  1 
ATOM   242  C CZ  . ARG A 1 29 ? -3.06328  -13.73999 -15.04142 1.000 26.31720 ? 29  ARG B CZ  1 
ATOM   243  N NH1 . ARG A 1 29 ? -4.08876  -13.70049 -15.87892 1.000 18.93581 ? 29  ARG B NH1 1 
ATOM   244  N NH2 . ARG A 1 29 ? -1.96072  -13.05169 -15.32505 1.000 28.78945 ? 29  ARG B NH2 1 
ATOM   245  N N   . ILE A 1 30 ? -7.25512  -17.16293 -9.91781  1.000 18.94427 ? 30  ILE B N   1 
ATOM   246  C CA  . ILE A 1 30 ? -7.97748  -18.41273 -9.67262  1.000 20.09916 ? 30  ILE B CA  1 
ATOM   247  C C   . ILE A 1 30 ? -9.37409  -18.34724 -10.28051 1.000 19.10732 ? 30  ILE B C   1 
ATOM   248  O O   . ILE A 1 30 ? -9.83534  -19.29344 -10.93284 1.000 20.65689 ? 30  ILE B O   1 
ATOM   249  C CB  . ILE A 1 30 ? -8.03373  -18.70926 -8.15954  1.000 22.93443 ? 30  ILE B CB  1 
ATOM   250  C CG1 . ILE A 1 30 ? -6.65918  -19.13157 -7.64371  1.000 20.30374 ? 30  ILE B CG1 1 
ATOM   251  C CG2 . ILE A 1 30 ? -9.09975  -19.76597 -7.83184  1.000 19.59810 ? 30  ILE B CG2 1 
ATOM   252  C CD1 . ILE A 1 30 ? -6.60853  -19.23965 -6.11410  1.000 26.33648 ? 30  ILE B CD1 1 
ATOM   253  N N   . VAL A 1 31 ? -10.06976 -17.22741 -10.07158 1.000 17.07416 ? 31  VAL B N   1 
ATOM   254  C CA  . VAL A 1 31 ? -11.40729 -17.05223 -10.63002 1.000 18.26661 ? 31  VAL B CA  1 
ATOM   255  C C   . VAL A 1 31 ? -11.37176 -17.11954 -12.15386 1.000 20.33098 ? 31  VAL B C   1 
ATOM   256  O O   . VAL A 1 31 ? -12.27077 -17.69617 -12.78059 1.000 20.31724 ? 31  VAL B O   1 
ATOM   257  C CB  . VAL A 1 31 ? -12.02635 -15.72788 -10.14464 1.000 18.78544 ? 31  VAL B CB  1 
ATOM   258  C CG1 . VAL A 1 31 ? -13.30753 -15.44442 -10.92137 1.000 19.03098 ? 31  VAL B CG1 1 
ATOM   259  C CG2 . VAL A 1 31 ? -12.30208 -15.77765 -8.64605  1.000 18.94620 ? 31  VAL B CG2 1 
ATOM   260  N N   . GLU A 1 32 ? -10.32943 -16.54837 -12.77296 1.000 17.15333 ? 32  GLU B N   1 
ATOM   261  C CA  . GLU A 1 32 ? -10.22863 -16.57014 -14.23539 1.000 23.44877 ? 32  GLU B CA  1 
ATOM   262  C C   . GLU A 1 32 ? -10.15293 -17.99739 -14.77354 1.000 21.63178 ? 32  GLU B C   1 
ATOM   263  O O   . GLU A 1 32 ? -10.80807 -18.32950 -15.76695 1.000 20.26678 ? 32  GLU B O   1 
ATOM   264  C CB  . GLU A 1 32 ? -9.00873  -15.76647 -14.70300 1.000 21.23955 ? 32  GLU B CB  1 
ATOM   265  C CG  . GLU A 1 32 ? -8.64524  -15.98172 -16.18467 1.000 23.12616 ? 32  GLU B CG  1 
ATOM   266  C CD  . GLU A 1 32 ? -7.44073  -15.16280 -16.62056 1.000 28.13964 ? 32  GLU B CD  1 
ATOM   267  O OE1 . GLU A 1 32 ? -6.49655  -15.00975 -15.81556 1.000 30.20691 ? 32  GLU B OE1 1 
ATOM   268  O OE2 . GLU A 1 32 ? -7.44259  -14.65442 -17.76165 1.000 30.17954 ? 32  GLU B OE2 1 
ATOM   269  N N   . GLY A 1 33 ? -9.34426  -18.85010 -14.14061 1.000 22.10775 ? 33  GLY B N   1 
ATOM   270  C CA  . GLY A 1 33 ? -9.25382  -20.23283 -14.57585 1.000 20.85247 ? 33  GLY B CA  1 
ATOM   271  C C   . GLY A 1 33 ? -10.58129 -20.96891 -14.51754 1.000 24.85019 ? 33  GLY B C   1 
ATOM   272  O O   . GLY A 1 33 ? -10.81676 -21.88650 -15.30229 1.000 24.84348 ? 33  GLY B O   1 
ATOM   273  N N   . ILE A 1 34 ? -11.46842 -20.56836 -13.61026 1.000 24.42172 ? 34  ILE B N   1 
ATOM   274  C CA  . ILE A 1 34 ? -12.75623 -21.24121 -13.43804 1.000 21.76494 ? 34  ILE B CA  1 
ATOM   275  C C   . ILE A 1 34 ? -13.83675 -20.61662 -14.30916 1.000 22.84663 ? 34  ILE B C   1 
ATOM   276  O O   . ILE A 1 34 ? -14.58260 -21.32270 -14.98734 1.000 24.31083 ? 34  ILE B O   1 
ATOM   277  C CB  . ILE A 1 34 ? -13.16997 -21.22206 -11.95066 1.000 21.32578 ? 34  ILE B CB  1 
ATOM   278  C CG1 . ILE A 1 34 ? -12.15052 -21.97238 -11.08839 1.000 22.86985 ? 34  ILE B CG1 1 
ATOM   279  C CG2 . ILE A 1 34 ? -14.57654 -21.79941 -11.77028 1.000 20.97451 ? 34  ILE B CG2 1 
ATOM   280  C CD1 . ILE A 1 34 ? -12.40341 -21.80527 -9.59773  1.000 20.11346 ? 34  ILE B CD1 1 
ATOM   281  N N   . LEU A 1 35 ? -13.96262 -19.29031 -14.29735 1.000 21.40518 ? 35  LEU B N   1 
ATOM   282  C CA  . LEU A 1 35 ? -15.06862 -18.61038 -14.96037 1.000 23.84733 ? 35  LEU B CA  1 
ATOM   283  C C   . LEU A 1 35 ? -14.65895 -17.86661 -16.22823 1.000 23.38954 ? 35  LEU B C   1 
ATOM   284  O O   . LEU A 1 35 ? -15.50889 -17.20269 -16.82911 1.000 23.80545 ? 35  LEU B O   1 
ATOM   285  C CB  . LEU A 1 35 ? -15.74178 -17.63127 -13.99213 1.000 20.66996 ? 35  LEU B CB  1 
ATOM   286  C CG  . LEU A 1 35 ? -16.38251 -18.24369 -12.75133 1.000 22.80548 ? 35  LEU B CG  1 
ATOM   287  C CD1 . LEU A 1 35 ? -16.97024 -17.14350 -11.89175 1.000 19.27636 ? 35  LEU B CD1 1 
ATOM   288  C CD2 . LEU A 1 35 ? -17.46963 -19.25159 -13.14984 1.000 25.61070 ? 35  LEU B CD2 1 
ATOM   289  N N   . LYS A 1 36 ? -13.38120 -17.93931 -16.62997 1.000 19.80569 ? 36  LYS B N   1 
ATOM   290  C CA  . LYS A 1 36 ? -12.89781 -17.42161 -17.92377 1.000 22.86126 ? 36  LYS B CA  1 
ATOM   291  C C   . LYS A 1 36 ? -13.16539 -15.93015 -18.11256 1.000 24.62381 ? 36  LYS B C   1 
ATOM   292  O O   . LYS A 1 36 ? -13.52351 -15.49071 -19.20426 1.000 30.93995 ? 36  LYS B O   1 
ATOM   293  C CB  . LYS A 1 36 ? -13.49030 -18.20413 -19.10420 1.000 21.56061 ? 36  LYS B CB  1 
ATOM   294  C CG  . LYS A 1 36 ? -13.46569 -19.72726 -18.94865 1.000 29.30258 ? 36  LYS B CG  1 
ATOM   295  C CD  . LYS A 1 36 ? -12.05850 -20.25589 -18.72274 1.000 25.38851 ? 36  LYS B CD  1 
ATOM   296  C CE  . LYS A 1 36 ? -12.09597 -21.72333 -18.33419 1.000 30.47359 ? 36  LYS B CE  1 
ATOM   297  N NZ  . LYS A 1 36 ? -10.73421 -22.30972 -18.29992 1.000 35.10045 ? 36  LYS B NZ  1 
ATOM   298  N N   . ARG A 1 37 ? -13.01105 -15.13927 -17.05368 1.000 24.28723 ? 37  ARG B N   1 
ATOM   299  C CA  . ARG A 1 37 ? -12.94644 -13.68732 -17.18791 1.000 24.34134 ? 37  ARG B CA  1 
ATOM   300  C C   . ARG A 1 37 ? -11.62071 -13.20542 -16.60695 1.000 24.04657 ? 37  ARG B C   1 
ATOM   301  O O   . ARG A 1 37 ? -11.27803 -13.58043 -15.47940 1.000 21.58592 ? 37  ARG B O   1 
ATOM   302  C CB  . ARG A 1 37 ? -14.12466 -12.97812 -16.47454 1.000 25.82255 ? 37  ARG B CB  1 
ATOM   303  C CG  . ARG A 1 37 ? -15.53589 -13.45749 -16.87588 1.000 28.93939 ? 37  ARG B CG  1 
ATOM   304  C CD  . ARG A 1 37 ? -15.93857 -13.00819 -18.27913 1.000 29.25170 ? 37  ARG B CD  1 
ATOM   305  N NE  . ARG A 1 37 ? -15.86153 -11.55986 -18.43770 1.000 25.06542 ? 37  ARG B NE  1 
ATOM   306  C CZ  . ARG A 1 37 ? -16.88480 -10.73215 -18.26418 1.000 31.73474 ? 37  ARG B CZ  1 
ATOM   307  N NH1 . ARG A 1 37 ? -18.08765 -11.18078 -17.92293 1.000 26.62502 ? 37  ARG B NH1 1 
ATOM   308  N NH2 . ARG A 1 37 ? -16.69664 -9.42008  -18.42945 1.000 25.68933 ? 37  ARG B NH2 1 
ATOM   309  N N   . PRO A 1 38 ? -10.84511 -12.40144 -17.33127 1.000 26.07169 ? 38  PRO B N   1 
ATOM   310  C CA  . PRO A 1 38 ? -9.51955  -11.99155 -16.83691 1.000 23.85931 ? 38  PRO B CA  1 
ATOM   311  C C   . PRO A 1 38 ? -9.62695  -11.10086 -15.61163 1.000 24.21099 ? 38  PRO B C   1 
ATOM   312  O O   . PRO A 1 38 ? -10.70005 -10.53262 -15.33397 1.000 22.37970 ? 38  PRO B O   1 
ATOM   313  C CB  . PRO A 1 38 ? -8.91931  -11.22700 -18.02991 1.000 27.69513 ? 38  PRO B CB  1 
ATOM   314  C CG  . PRO A 1 38 ? -10.11820 -10.74771 -18.81088 1.000 30.73025 ? 38  PRO B CG  1 
ATOM   315  C CD  . PRO A 1 38 ? -11.09740 -11.90274 -18.69523 1.000 28.63565 ? 38  PRO B CD  1 
ATOM   316  N N   . PRO A 1 39 ? -8.52539  -10.94987 -14.85695 1.000 22.95782 ? 39  PRO B N   1 
ATOM   317  C CA  . PRO A 1 39 ? -8.58255  -10.13418 -13.62817 1.000 21.96638 ? 39  PRO B CA  1 
ATOM   318  C C   . PRO A 1 39 ? -9.05231  -8.70600  -13.84735 1.000 24.26843 ? 39  PRO B C   1 
ATOM   319  O O   . PRO A 1 39 ? -9.80575  -8.18201  -13.01995 1.000 22.46148 ? 39  PRO B O   1 
ATOM   320  C CB  . PRO A 1 39 ? -7.13581  -10.19267 -13.11122 1.000 22.71527 ? 39  PRO B CB  1 
ATOM   321  C CG  . PRO A 1 39 ? -6.63077  -11.53357 -13.59729 1.000 20.59247 ? 39  PRO B CG  1 
ATOM   322  C CD  . PRO A 1 39 ? -7.23797  -11.66434 -14.98233 1.000 21.82203 ? 39  PRO B CD  1 
ATOM   323  N N   . ASP A 1 40 ? -8.67054  -8.05955  -14.94647 1.000 27.49354 ? 40  ASP B N   1 
ATOM   324  C CA  . ASP A 1 40 ? -9.11287  -6.67911  -15.10072 1.000 29.79859 ? 40  ASP B CA  1 
ATOM   325  C C   . ASP A 1 40 ? -10.61568 -6.56712  -15.34041 1.000 28.09530 ? 40  ASP B C   1 
ATOM   326  O O   . ASP A 1 40 ? -11.16060 -5.46075  -15.24625 1.000 30.97697 ? 40  ASP B O   1 
ATOM   327  C CB  . ASP A 1 40 ? -8.31906  -5.97410  -16.21738 1.000 34.90154 ? 40  ASP B CB  1 
ATOM   328  C CG  . ASP A 1 40 ? -8.74533  -6.38962  -17.61223 1.000 37.78058 ? 40  ASP B CG  1 
ATOM   329  O OD1 . ASP A 1 40 ? -8.89487  -7.59973  -17.85395 1.000 43.95701 ? 40  ASP B OD1 1 
ATOM   330  O OD2 . ASP A 1 40 ? -8.92177  -5.50042  -18.47811 1.000 52.14936 ? 40  ASP B OD2 1 
ATOM   331  N N   . GLU A 1 41 ? -11.30733 -7.67677  -15.59231 1.000 23.36626 ? 41  GLU B N   1 
ATOM   332  C CA  . GLU A 1 41 ? -12.76013 -7.67469  -15.72137 1.000 24.84949 ? 41  GLU B CA  1 
ATOM   333  C C   . GLU A 1 41 ? -13.46400 -8.16393  -14.45256 1.000 22.74390 ? 41  GLU B C   1 
ATOM   334  O O   . GLU A 1 41 ? -14.65877 -8.48645  -14.49349 1.000 22.30250 ? 41  GLU B O   1 
ATOM   335  C CB  . GLU A 1 41 ? -13.18211 -8.51814  -16.93042 1.000 26.59201 ? 41  GLU B CB  1 
ATOM   336  C CG  . GLU A 1 41 ? -12.71295 -7.94679  -18.25603 1.000 30.83129 ? 41  GLU B CG  1 
ATOM   337  C CD  . GLU A 1 41 ? -12.98367 -8.86798  -19.43261 1.000 34.42749 ? 41  GLU B CD  1 
ATOM   338  O OE1 . GLU A 1 41 ? -13.94673 -9.65990  -19.38539 1.000 32.28204 ? 41  GLU B OE1 1 
ATOM   339  O OE2 . GLU A 1 41 ? -12.21320 -8.80907  -20.41002 1.000 37.65972 ? 41  GLU B OE2 1 
ATOM   340  N N   . GLN A 1 42 ? -12.75668 -8.20217  -13.32453 1.000 21.10656 ? 42  GLN B N   1 
ATOM   341  C CA  . GLN A 1 42 ? -13.30970 -8.64813  -12.05324 1.000 19.77176 ? 42  GLN B CA  1 
ATOM   342  C C   . GLN A 1 42 ? -13.18495 -7.55803  -11.00054 1.000 21.20684 ? 42  GLN B C   1 
ATOM   343  O O   . GLN A 1 42 ? -12.16598 -6.86675  -10.92619 1.000 20.37837 ? 42  GLN B O   1 
ATOM   344  C CB  . GLN A 1 42 ? -12.57903 -9.89499  -11.52786 1.000 19.29975 ? 42  GLN B CB  1 
ATOM   345  C CG  . GLN A 1 42 ? -12.59099 -11.12104 -12.42755 1.000 18.16316 ? 42  GLN B CG  1 
ATOM   346  C CD  . GLN A 1 42 ? -11.76572 -12.25913 -11.80619 1.000 19.52651 ? 42  GLN B CD  1 
ATOM   347  O OE1 . GLN A 1 42 ? -11.75627 -12.43709 -10.58164 1.000 17.78170 ? 42  GLN B OE1 1 
ATOM   348  N NE2 . GLN A 1 42 ? -11.04208 -12.99491 -12.63735 1.000 17.34415 ? 42  GLN B NE2 1 
ATOM   349  N N   . ARG A 1 43 ? -14.20354 -7.44145  -10.15486 1.000 18.64013 ? 43  ARG B N   1 
ATOM   350  C CA  . ARG A 1 43 ? -14.09027 -6.75170  -8.88205  1.000 19.03044 ? 43  ARG B CA  1 
ATOM   351  C C   . ARG A 1 43 ? -14.37986 -7.74513  -7.77275  1.000 21.93527 ? 43  ARG B C   1 
ATOM   352  O O   . ARG A 1 43 ? -15.40902 -8.43177  -7.80786  1.000 19.03053 ? 43  ARG B O   1 
ATOM   353  C CB  . ARG A 1 43 ? -15.06140 -5.58017  -8.77319  1.000 19.59993 ? 43  ARG B CB  1 
ATOM   354  C CG  . ARG A 1 43 ? -14.65238 -4.33831  -9.53374  1.000 24.32328 ? 43  ARG B CG  1 
ATOM   355  C CD  . ARG A 1 43 ? -15.81140 -3.37535  -9.50519  1.000 25.72709 ? 43  ARG B CD  1 
ATOM   356  N NE  . ARG A 1 43 ? -15.45437 -2.05768  -10.00592 1.000 31.98855 ? 43  ARG B NE  1 
ATOM   357  C CZ  . ARG A 1 43 ? -16.28553 -1.02368  -10.02290 1.000 34.69931 ? 43  ARG B CZ  1 
ATOM   358  N NH1 . ARG A 1 43 ? -17.52474 -1.12237  -9.55247  1.000 32.75115 ? 43  ARG B NH1 1 
ATOM   359  N NH2 . ARG A 1 43 ? -15.86602 0.13476   -10.52423 1.000 35.07005 ? 43  ARG B NH2 1 
ATOM   360  N N   . LEU A 1 44 ? -13.49356 -7.79811  -6.77994  1.000 18.18500 ? 44  LEU B N   1 
ATOM   361  C CA  . LEU A 1 44 ? -13.69195 -8.62692  -5.60016  1.000 16.82047 ? 44  LEU B CA  1 
ATOM   362  C C   . LEU A 1 44 ? -13.98826 -7.73356  -4.40567  1.000 19.55199 ? 44  LEU B C   1 
ATOM   363  O O   . LEU A 1 44 ? -13.44688 -6.62511  -4.30048  1.000 18.06521 ? 44  LEU B O   1 
ATOM   364  C CB  . LEU A 1 44 ? -12.46997 -9.50632  -5.31894  1.000 15.39952 ? 44  LEU B CB  1 
ATOM   365  C CG  . LEU A 1 44 ? -12.04097 -10.47693 -6.43377  1.000 19.26523 ? 44  LEU B CG  1 
ATOM   366  C CD1 . LEU A 1 44 ? -10.88468 -11.38234 -5.97433  1.000 19.10806 ? 44  LEU B CD1 1 
ATOM   367  C CD2 . LEU A 1 44 ? -13.20987 -11.31300 -6.91212  1.000 19.16827 ? 44  LEU B CD2 1 
ATOM   368  N N   . TYR A 1 45 ? -14.84026 -8.23403  -3.50230  1.000 17.65896 ? 45  TYR B N   1 
ATOM   369  C CA  . TYR A 1 45 ? -15.40882 -7.46112  -2.40830  1.000 18.41904 ? 45  TYR B CA  1 
ATOM   370  C C   . TYR A 1 45 ? -15.31418 -8.23615  -1.10911  1.000 20.51710 ? 45  TYR B C   1 
ATOM   371  O O   . TYR A 1 45 ? -15.45942 -9.46180  -1.09616  1.000 20.55215 ? 45  TYR B O   1 
ATOM   372  C CB  . TYR A 1 45 ? -16.89474 -7.15358  -2.62917  1.000 18.93197 ? 45  TYR B CB  1 
ATOM   373  C CG  . TYR A 1 45 ? -17.20534 -6.18689  -3.72197  1.000 20.48821 ? 45  TYR B CG  1 
ATOM   374  C CD1 . TYR A 1 45 ? -17.24165 -6.60246  -5.04382  1.000 20.43220 ? 45  TYR B CD1 1 
ATOM   375  C CD2 . TYR A 1 45 ? -17.49078 -4.84944  -3.43483  1.000 21.27960 ? 45  TYR B CD2 1 
ATOM   376  C CE1 . TYR A 1 45 ? -17.54109 -5.71417  -6.06168  1.000 22.01516 ? 45  TYR B CE1 1 
ATOM   377  C CE2 . TYR A 1 45 ? -17.78016 -3.95213  -4.44228  1.000 22.08047 ? 45  TYR B CE2 1 
ATOM   378  C CZ  . TYR A 1 45 ? -17.81063 -4.39253  -5.75329  1.000 25.07164 ? 45  TYR B CZ  1 
ATOM   379  O OH  . TYR A 1 45 ? -18.10464 -3.51918  -6.77179  1.000 29.15421 ? 45  TYR B OH  1 
ATOM   380  N N   . LYS A 1 46 ? -15.09090 -7.51460  -0.01721  1.000 19.40309 ? 46  LYS B N   1 
ATOM   381  C CA  . LYS A 1 46 ? -15.41256 -7.99192  1.31941   1.000 20.06383 ? 46  LYS B CA  1 
ATOM   382  C C   . LYS A 1 46 ? -16.54770 -7.11321  1.82264   1.000 24.20211 ? 46  LYS B C   1 
ATOM   383  O O   . LYS A 1 46 ? -16.39278 -5.88689  1.91436   1.000 22.85365 ? 46  LYS B O   1 
ATOM   384  C CB  . LYS A 1 46 ? -14.20164 -7.94092  2.24913   1.000 23.55729 ? 46  LYS B CB  1 
ATOM   385  C CG  . LYS A 1 46 ? -14.45401 -8.54941  3.63363   1.000 26.19970 ? 46  LYS B CG  1 
ATOM   386  C CD  . LYS A 1 46 ? -13.14089 -8.67929  4.38988   1.000 32.00621 ? 46  LYS B CD  1 
ATOM   387  C CE  . LYS A 1 46 ? -13.31025 -8.47119  5.88235   1.000 36.98399 ? 46  LYS B CE  1 
ATOM   388  N NZ  . LYS A 1 46 ? -14.33106 -9.38737  6.45709   1.000 36.15048 ? 46  LYS B NZ  1 
ATOM   389  N N   . ASP A 1 47 ? -17.68678 -7.74091  2.12471   1.000 24.23732 ? 47  ASP B N   1 
ATOM   390  C CA  . ASP A 1 47 ? -18.96509 -7.04323  2.24299   1.000 21.21557 ? 47  ASP B CA  1 
ATOM   391  C C   . ASP A 1 47 ? -19.12026 -6.10914  1.04439   1.000 21.80013 ? 47  ASP B C   1 
ATOM   392  O O   . ASP A 1 47 ? -19.07860 -6.56783  -0.10374  1.000 20.82343 ? 47  ASP B O   1 
ATOM   393  C CB  . ASP A 1 47 ? -19.06437 -6.30894  3.58094   1.000 23.73634 ? 47  ASP B CB  1 
ATOM   394  C CG  . ASP A 1 47 ? -18.82187 -7.23900  4.77339   1.000 32.16927 ? 47  ASP B CG  1 
ATOM   395  O OD1 . ASP A 1 47 ? -19.39053 -8.35766  4.79582   1.000 40.30695 ? 47  ASP B OD1 1 
ATOM   396  O OD2 . ASP A 1 47 ? -18.04566 -6.86639  5.68129   1.000 39.24793 ? 47  ASP B OD2 1 
ATOM   397  N N   . ASP A 1 48 ? -19.27339 -4.80774  1.26665   1.000 16.93924 ? 48  ASP B N   1 
ATOM   398  C CA  . ASP A 1 48 ? -19.40341 -3.88055  0.14590   1.000 20.77590 ? 48  ASP B CA  1 
ATOM   399  C C   . ASP A 1 48 ? -18.09756 -3.15673  -0.19552  1.000 20.90551 ? 48  ASP B C   1 
ATOM   400  O O   . ASP A 1 48 ? -18.11301 -2.23212  -1.01553  1.000 22.34626 ? 48  ASP B O   1 
ATOM   401  C CB  . ASP A 1 48 ? -20.52298 -2.86109  0.41925   1.000 23.03237 ? 48  ASP B CB  1 
ATOM   402  C CG  . ASP A 1 48 ? -20.21780 -1.93155  1.59575   1.000 25.84531 ? 48  ASP B CG  1 
ATOM   403  O OD1 . ASP A 1 48 ? -19.24713 -2.17872  2.34116   1.000 24.22305 ? 48  ASP B OD1 1 
ATOM   404  O OD2 . ASP A 1 48 ? -20.96006 -0.93546  1.77839   1.000 31.66223 ? 48  ASP B OD2 1 
ATOM   405  N N   . GLN A 1 49 ? -16.96673 -3.57822  0.37622   1.000 19.16960 ? 49  GLN B N   1 
ATOM   406  C CA  . GLN A 1 49 ? -15.67823 -2.91340  0.17835   1.000 19.57965 ? 49  GLN B CA  1 
ATOM   407  C C   . GLN A 1 49 ? -14.88853 -3.57531  -0.94850  1.000 20.16564 ? 49  GLN B C   1 
ATOM   408  O O   . GLN A 1 49 ? -14.58417 -4.77176  -0.88162  1.000 18.96520 ? 49  GLN B O   1 
ATOM   409  C CB  . GLN A 1 49 ? -14.87288 -2.93109  1.47760   1.000 17.28583 ? 49  GLN B CB  1 
ATOM   410  C CG  . GLN A 1 49 ? -15.58531 -2.16476  2.58345   1.000 22.51715 ? 49  GLN B CG  1 
ATOM   411  C CD  . GLN A 1 49 ? -15.87125 -0.74430  2.14525   1.000 22.80163 ? 49  GLN B CD  1 
ATOM   412  O OE1 . GLN A 1 49 ? -14.95474 -0.01910  1.76205   1.000 18.88914 ? 49  GLN B OE1 1 
ATOM   413  N NE2 . GLN A 1 49 ? -17.14267 -0.35412  2.15502   1.000 21.69680 ? 49  GLN B NE2 1 
ATOM   414  N N   . LEU A 1 50 ? -14.55127 -2.78833  -1.96921  1.000 19.48212 ? 50  LEU B N   1 
ATOM   415  C CA  . LEU A 1 50 ? -13.65254 -3.23708  -3.02247  1.000 22.42880 ? 50  LEU B CA  1 
ATOM   416  C C   . LEU A 1 50 ? -12.28147 -3.60033  -2.46636  1.000 25.72318 ? 50  LEU B C   1 
ATOM   417  O O   . LEU A 1 50 ? -11.70965 -2.86848  -1.65387  1.000 27.26744 ? 50  LEU B O   1 
ATOM   418  C CB  . LEU A 1 50 ? -13.48310 -2.14068  -4.06867  1.000 24.85951 ? 50  LEU B CB  1 
ATOM   419  C CG  . LEU A 1 50 ? -14.49906 -2.04667  -5.19008  1.000 30.97856 ? 50  LEU B CG  1 
ATOM   420  C CD1 . LEU A 1 50 ? -14.33701 -0.69929  -5.91747  1.000 30.89379 ? 50  LEU B CD1 1 
ATOM   421  C CD2 . LEU A 1 50 ? -14.29278 -3.21344  -6.13839  1.000 26.49048 ? 50  LEU B CD2 1 
ATOM   422  N N   . LEU A 1 51 ? -11.73277 -4.71553  -2.94634  1.000 21.34334 ? 51  LEU B N   1 
ATOM   423  C CA  . LEU A 1 51 ? -10.40932 -5.17021  -2.54370  1.000 21.59117 ? 51  LEU B CA  1 
ATOM   424  C C   . LEU A 1 51 ? -9.37399  -4.78927  -3.60233  1.000 22.59493 ? 51  LEU B C   1 
ATOM   425  O O   . LEU A 1 51 ? -9.55311  -5.08673  -4.78722  1.000 23.77225 ? 51  LEU B O   1 
ATOM   426  C CB  . LEU A 1 51 ? -10.42485 -6.68041  -2.31067  1.000 19.53377 ? 51  LEU B CB  1 
ATOM   427  C CG  . LEU A 1 51 ? -11.45855 -7.18443  -1.29772  1.000 24.31653 ? 51  LEU B CG  1 
ATOM   428  C CD1 . LEU A 1 51 ? -11.41693 -8.68952  -1.20486  1.000 19.06772 ? 51  LEU B CD1 1 
ATOM   429  C CD2 . LEU A 1 51 ? -11.23471 -6.55837  0.09307   1.000 24.32101 ? 51  LEU B CD2 1 
ATOM   430  N N   . ASP A 1 52 ? -8.29516  -4.13249  -3.17195  1.000 24.75762 ? 52  ASP B N   1 
ATOM   431  C CA  . ASP A 1 52 ? -7.22406  -3.70808  -4.07801  1.000 28.49606 ? 52  ASP B CA  1 
ATOM   432  C C   . ASP A 1 52 ? -6.32977  -4.88455  -4.48963  1.000 24.43507 ? 52  ASP B C   1 
ATOM   433  O O   . ASP A 1 52 ? -5.91514  -5.68939  -3.64860  1.000 19.81485 ? 52  ASP B O   1 
ATOM   434  C CB  . ASP A 1 52 ? -6.36141  -2.62495  -3.41092  1.000 26.87079 ? 52  ASP B CB  1 
ATOM   435  C CG  . ASP A 1 52 ? -7.10859  -1.30276  -3.20463  1.000 39.22221 ? 52  ASP B CG  1 
ATOM   436  O OD1 . ASP A 1 52 ? -7.88413  -0.88716  -4.09396  1.000 40.69483 ? 52  ASP B OD1 1 
ATOM   437  O OD2 . ASP A 1 52 ? -6.90772  -0.66638  -2.14412  1.000 45.13226 ? 52  ASP B OD2 1 
ATOM   438  N N   . ASP A 1 53 ? -5.99156  -4.94356  -5.78843  1.000 24.31133 ? 53  ASP B N   1 
ATOM   439  C CA  . ASP A 1 53 ? -5.21365  -6.06346  -6.33868  1.000 24.34301 ? 53  ASP B CA  1 
ATOM   440  C C   . ASP A 1 53 ? -3.91089  -6.34154  -5.59084  1.000 22.96455 ? 53  ASP B C   1 
ATOM   441  O O   . ASP A 1 53 ? -3.49011  -7.50624  -5.49241  1.000 24.26132 ? 53  ASP B O   1 
ATOM   442  C CB  . ASP A 1 53 ? -4.88680  -5.81297  -7.81660  1.000 24.79105 ? 53  ASP B CB  1 
ATOM   443  C CG  . ASP A 1 53 ? -6.06253  -6.08460  -8.72913  1.000 27.32127 ? 53  ASP B CG  1 
ATOM   444  O OD1 . ASP A 1 53 ? -5.94834  -5.86077  -9.94977  1.000 29.84325 ? 53  ASP B OD1 1 
ATOM   445  O OD2 . ASP A 1 53 ? -7.11805  -6.51479  -8.22602  1.000 31.58995 ? 53  ASP B OD2 1 
ATOM   446  N N   . GLY A 1 54 ? -3.24773  -5.30259  -5.06915  1.000 23.89028 ? 54  GLY B N   1 
ATOM   447  C CA  . GLY A 1 54 ? -1.94736  -5.49063  -4.43728  1.000 21.43319 ? 54  GLY B CA  1 
ATOM   448  C C   . GLY A 1 54 ? -1.97095  -5.92758  -2.98147  1.000 26.98758 ? 54  GLY B C   1 
ATOM   449  O O   . GLY A 1 54 ? -0.91832  -6.27161  -2.42888  1.000 25.06063 ? 54  GLY B O   1 
ATOM   450  N N   . LYS A 1 55 ? -3.13551  -5.93320  -2.34247  1.000 26.96919 ? 55  LYS B N   1 
ATOM   451  C CA  . LYS A 1 55 ? -3.21448  -6.31571  -0.93890  1.000 24.80847 ? 55  LYS B CA  1 
ATOM   452  C C   . LYS A 1 55 ? -3.18280  -7.82971  -0.77989  1.000 25.14629 ? 55  LYS B C   1 
ATOM   453  O O   . LYS A 1 55 ? -3.67525  -8.57500  -1.63176  1.000 23.72499 ? 55  LYS B O   1 
ATOM   454  C CB  . LYS A 1 55 ? -4.49515  -5.75410  -0.31462  1.000 26.43947 ? 55  LYS B CB  1 
ATOM   455  C CG  . LYS A 1 55 ? -4.73854  -4.30029  -0.68279  1.000 27.02604 ? 55  LYS B CG  1 
ATOM   456  C CD  . LYS A 1 55 ? -4.85110  -3.38578  0.53530   1.000 40.08748 ? 55  LYS B CD  1 
ATOM   457  C CE  . LYS A 1 55 ? -6.14918  -3.61865  1.30722   1.000 40.81105 ? 55  LYS B CE  1 
ATOM   458  N NZ  . LYS A 1 55 ? -6.38926  -2.58560  2.36133   1.000 42.76264 ? 55  LYS B NZ  1 
ATOM   459  N N   . THR A 1 56 ? -2.60870  -8.28524  0.32926   1.000 22.86402 ? 56  THR B N   1 
ATOM   460  C CA  . THR A 1 56 ? -2.72350  -9.69580  0.65726   1.000 25.81444 ? 56  THR B CA  1 
ATOM   461  C C   . THR A 1 56 ? -4.12421  -9.98576  1.18784   1.000 26.36785 ? 56  THR B C   1 
ATOM   462  O O   . THR A 1 56 ? -4.85729  -9.08174  1.59789   1.000 27.01982 ? 56  THR B O   1 
ATOM   463  C CB  . THR A 1 56 ? -1.67412  -10.12435 1.69177   1.000 27.48276 ? 56  THR B CB  1 
ATOM   464  O OG1 . THR A 1 56 ? -1.91880  -9.45167  2.93243   1.000 27.48554 ? 56  THR B OG1 1 
ATOM   465  C CG2 . THR A 1 56 ? -0.25826  -9.79283  1.21121   1.000 27.18027 ? 56  THR B CG2 1 
ATOM   466  N N   . LEU A 1 57 ? -4.50242  -11.26898 1.16802   1.000 27.56976 ? 57  LEU B N   1 
ATOM   467  C CA  . LEU A 1 57 ? -5.80679  -11.63529 1.71461   1.000 26.72436 ? 57  LEU B CA  1 
ATOM   468  C C   . LEU A 1 57 ? -5.85868  -11.37130 3.21620   1.000 30.34140 ? 57  LEU B C   1 
ATOM   469  O O   . LEU A 1 57 ? -6.90479  -10.96999 3.73984   1.000 27.87776 ? 57  LEU B O   1 
ATOM   470  C CB  . LEU A 1 57 ? -6.12943  -13.09797 1.39040   1.000 23.54448 ? 57  LEU B CB  1 
ATOM   471  C CG  . LEU A 1 57 ? -6.16993  -13.43035 -0.11447  1.000 23.54764 ? 57  LEU B CG  1 
ATOM   472  C CD1 . LEU A 1 57 ? -6.54725  -14.89280 -0.37857  1.000 24.82020 ? 57  LEU B CD1 1 
ATOM   473  C CD2 . LEU A 1 57 ? -7.09546  -12.49699 -0.87267  1.000 21.73644 ? 57  LEU B CD2 1 
ATOM   474  N N   . GLY A 1 58 ? -4.73002  -11.54770 3.91323   1.000 30.80502 ? 58  GLY B N   1 
ATOM   475  C CA  . GLY A 1 58 ? -4.68180  -11.21651 5.33005   1.000 31.06415 ? 58  GLY B CA  1 
ATOM   476  C C   . GLY A 1 58 ? -4.89445  -9.73909  5.59166   1.000 31.53427 ? 58  GLY B C   1 
ATOM   477  O O   . GLY A 1 58 ? -5.63455  -9.36056  6.50364   1.000 33.48088 ? 58  GLY B O   1 
ATOM   478  N N   . GLU A 1 59 ? -4.26689  -8.88368  4.78179   1.000 26.66970 ? 59  GLU B N   1 
ATOM   479  C CA  . GLU A 1 59 ? -4.47560  -7.44729  4.92070   1.000 29.33410 ? 59  GLU B CA  1 
ATOM   480  C C   . GLU A 1 59 ? -5.91936  -7.06131  4.62960   1.000 33.45254 ? 59  GLU B C   1 
ATOM   481  O O   . GLU A 1 59 ? -6.40073  -6.03494  5.12261   1.000 35.84176 ? 59  GLU B O   1 
ATOM   482  C CB  . GLU A 1 59 ? -3.51922  -6.68125  3.99555   1.000 31.65451 ? 59  GLU B CB  1 
ATOM   483  C CG  . GLU A 1 59 ? -2.05449  -6.69211  4.46369   1.000 29.92458 ? 59  GLU B CG  1 
ATOM   484  C CD  . GLU A 1 59 ? -1.05329  -6.33248  3.36182   1.000 36.80043 ? 59  GLU B CD  1 
ATOM   485  O OE1 . GLU A 1 59 ? -1.45040  -6.19643  2.17663   1.000 35.28593 ? 59  GLU B OE1 1 
ATOM   486  O OE2 . GLU A 1 59 ? 0.14821   -6.19620  3.68467   1.000 41.54036 ? 59  GLU B OE2 1 
ATOM   487  N N   . CYS A 1 60 ? -6.61962  -7.85603  3.82364   1.000 32.33883 ? 60  CYS B N   1 
ATOM   488  C CA  . CYS A 1 60 ? -8.02898  -7.61587  3.56770   1.000 30.94231 ? 60  CYS B CA  1 
ATOM   489  C C   . CYS A 1 60 ? -8.91594  -8.10236  4.70242   1.000 32.22473 ? 60  CYS B C   1 
ATOM   490  O O   . CYS A 1 60 ? -10.09855 -7.74649  4.73264   1.000 38.12970 ? 60  CYS B O   1 
ATOM   491  C CB  . CYS A 1 60 ? -8.44965  -8.28563  2.25460   1.000 30.12952 ? 60  CYS B CB  1 
ATOM   492  S SG  . CYS A 1 60 ? -7.76165  -7.51855  0.74771   1.000 31.10332 ? 60  CYS B SG  1 
ATOM   493  N N   . GLY A 1 61 ? -8.37760  -8.89192  5.62980   1.000 30.05901 ? 61  GLY B N   1 
ATOM   494  C CA  . GLY A 1 61 ? -9.13554  -9.41155  6.74618   1.000 28.41168 ? 61  GLY B CA  1 
ATOM   495  C C   . GLY A 1 61 ? -9.48608  -10.88254 6.67217   1.000 36.83881 ? 61  GLY B C   1 
ATOM   496  O O   . GLY A 1 61 ? -10.26976 -11.35720 7.50259   1.000 38.32612 ? 61  GLY B O   1 
ATOM   497  N N   . PHE A 1 62 ? -8.95362  -11.61839 5.70770   1.000 32.40990 ? 62  PHE B N   1 
ATOM   498  C CA  . PHE A 1 62 ? -9.20431  -13.05139 5.59863   1.000 31.75680 ? 62  PHE B CA  1 
ATOM   499  C C   . PHE A 1 62 ? -8.05119  -13.75501 6.30203   1.000 32.84082 ? 62  PHE B C   1 
ATOM   500  O O   . PHE A 1 62 ? -6.93297  -13.81944 5.78470   1.000 35.89235 ? 62  PHE B O   1 
ATOM   501  C CB  . PHE A 1 62 ? -9.34909  -13.47647 4.13968   1.000 29.29969 ? 62  PHE B CB  1 
ATOM   502  C CG  . PHE A 1 62 ? -10.45110 -12.75318 3.40787   1.000 27.71341 ? 62  PHE B CG  1 
ATOM   503  C CD1 . PHE A 1 62 ? -11.77962 -12.96128 3.74341   1.000 21.55017 ? 62  PHE B CD1 1 
ATOM   504  C CD2 . PHE A 1 62 ? -10.15629 -11.86348 2.38511   1.000 27.26137 ? 62  PHE B CD2 1 
ATOM   505  C CE1 . PHE A 1 62 ? -12.80271 -12.29024 3.07603   1.000 22.82269 ? 62  PHE B CE1 1 
ATOM   506  C CE2 . PHE A 1 62 ? -11.16969 -11.18988 1.70877   1.000 25.52522 ? 62  PHE B CE2 1 
ATOM   507  C CZ  . PHE A 1 62 ? -12.50230 -11.40474 2.05711   1.000 22.00980 ? 62  PHE B CZ  1 
ATOM   508  N N   . THR A 1 63 ? -8.32004  -14.25161 7.50079   1.000 37.56109 ? 63  THR B N   1 
ATOM   509  C CA  . THR A 1 63 ? -7.34666  -14.98298 8.29011   1.000 37.39654 ? 63  THR B CA  1 
ATOM   510  C C   . THR A 1 63 ? -7.90751  -16.35245 8.63180   1.000 34.88617 ? 63  THR B C   1 
ATOM   511  O O   . THR A 1 63 ? -9.07379  -16.65605 8.38334   1.000 34.76535 ? 63  THR B O   1 
ATOM   512  C CB  . THR A 1 63 ? -6.98733  -14.23505 9.58215   1.000 36.99006 ? 63  THR B CB  1 
ATOM   513  O OG1 . THR A 1 63 ? -8.05249  -14.39081 10.52987  1.000 34.79752 ? 63  THR B OG1 1 
ATOM   514  C CG2 . THR A 1 63 ? -6.76570  -12.75291 9.30212   1.000 33.75632 ? 63  THR B CG2 1 
ATOM   515  N N   . SER A 1 64 ? -7.05188  -17.16559 9.24189   1.000 38.73332 ? 64  SER B N   1 
ATOM   516  C CA  . SER A 1 64 ? -7.38333  -18.52920 9.61663   1.000 40.10662 ? 64  SER B CA  1 
ATOM   517  C C   . SER A 1 64 ? -8.40713  -18.60457 10.73583  1.000 43.27401 ? 64  SER B C   1 
ATOM   518  O O   . SER A 1 64 ? -8.95025  -19.68560 10.98714  1.000 46.37257 ? 64  SER B O   1 
ATOM   519  C CB  . SER A 1 64 ? -6.09819  -19.23310 10.00664  1.000 48.93719 ? 64  SER B CB  1 
ATOM   520  O OG  . SER A 1 64 ? -5.06644  -18.71616 9.18760   1.000 53.68547 ? 64  SER B OG  1 
ATOM   521  N N   . GLN A 1 65 ? -8.69031  -17.49035 11.40123  1.000 43.90756 ? 65  GLN B N   1 
ATOM   522  C CA  . GLN A 1 65 ? -9.73589  -17.44608 12.40994  1.000 39.54194 ? 65  GLN B CA  1 
ATOM   523  C C   . GLN A 1 65 ? -11.08292 -17.06699 11.81660  1.000 39.37234 ? 65  GLN B C   1 
ATOM   524  O O   . GLN A 1 65 ? -12.12208 -17.51494 12.31213  1.000 40.79143 ? 65  GLN B O   1 
ATOM   525  C CB  . GLN A 1 65 ? -9.34383  -16.45677 13.51201  1.000 46.46100 ? 65  GLN B CB  1 
ATOM   526  C CG  . GLN A 1 65 ? -8.15039  -16.92134 14.36807  1.000 53.48196 ? 65  GLN B CG  1 
ATOM   527  C CD  . GLN A 1 65 ? -6.86073  -17.13846 13.56902  1.000 58.43151 ? 65  GLN B CD  1 
ATOM   528  O OE1 . GLN A 1 65 ? -6.21237  -16.17873 13.13506  1.000 59.18853 ? 65  GLN B OE1 1 
ATOM   529  N NE2 . GLN A 1 65 ? -6.49285  -18.40835 13.36450  1.000 58.62924 ? 65  GLN B NE2 1 
ATOM   530  N N   . THR A 1 66 ? -11.08398 -16.26986 10.75089  1.000 33.30422 ? 66  THR B N   1 
ATOM   531  C CA  . THR A 1 66 ? -12.30880 -15.83189 10.09363  1.000 36.24884 ? 66  THR B CA  1 
ATOM   532  C C   . THR A 1 66 ? -12.60335 -16.56930 8.79113   1.000 30.18651 ? 66  THR B C   1 
ATOM   533  O O   . THR A 1 66 ? -13.65231 -16.32783 8.18697   1.000 28.89527 ? 66  THR B O   1 
ATOM   534  C CB  . THR A 1 66 ? -12.22857 -14.33379 9.79470   1.000 35.93967 ? 66  THR B CB  1 
ATOM   535  O OG1 . THR A 1 66 ? -11.00069 -14.06619 9.10494   1.000 41.13421 ? 66  THR B OG1 1 
ATOM   536  C CG2 . THR A 1 66 ? -12.27636 -13.52599 11.07825  1.000 39.02786 ? 66  THR B CG2 1 
ATOM   537  N N   . ALA A 1 67 ? -11.70214 -17.43989 8.32182   1.000 25.27443 ? 67  ALA B N   1 
ATOM   538  C CA  . ALA A 1 67 ? -11.87512 -18.09286 7.01932   1.000 24.52728 ? 67  ALA B CA  1 
ATOM   539  C C   . ALA A 1 67 ? -11.44759 -19.55696 7.17025   1.000 23.07026 ? 67  ALA B C   1 
ATOM   540  O O   . ALA A 1 67 ? -10.37500 -19.96292 6.72249   1.000 22.61934 ? 67  ALA B O   1 
ATOM   541  C CB  . ALA A 1 67 ? -11.07944 -17.37274 5.93024   1.000 23.07959 ? 67  ALA B CB  1 
ATOM   542  N N   . ARG A 1 68 ? -12.31218 -20.36140 7.79829   1.000 23.04667 ? 68  ARG B N   1 
ATOM   543  C CA  . ARG A 1 68 ? -11.97835 -21.73383 8.15381   1.000 22.90017 ? 68  ARG B CA  1 
ATOM   544  C C   . ARG A 1 68 ? -12.66301 -22.71123 7.21222   1.000 20.17251 ? 68  ARG B C   1 
ATOM   545  O O   . ARG A 1 68 ? -13.69035 -22.38547 6.61336   1.000 19.33106 ? 68  ARG B O   1 
ATOM   546  C CB  . ARG A 1 68 ? -12.40494 -22.01987 9.59815   1.000 26.41327 ? 68  ARG B CB  1 
ATOM   547  C CG  . ARG A 1 68 ? -11.80009 -21.08821 10.63648  1.000 33.28334 ? 68  ARG B CG  1 
ATOM   548  C CD  . ARG A 1 68 ? -12.84817 -20.72008 11.67990  1.000 35.15366 ? 68  ARG B CD  1 
ATOM   549  N NE  . ARG A 1 68 ? -12.77302 -21.60336 12.83342  1.000 47.08245 ? 68  ARG B NE  1 
ATOM   550  C CZ  . ARG A 1 68 ? -13.75162 -21.78884 13.71115  1.000 44.70554 ? 68  ARG B CZ  1 
ATOM   551  N NH1 . ARG A 1 68 ? -14.93471 -21.21103 13.56056  1.000 42.77826 ? 68  ARG B NH1 1 
ATOM   552  N NH2 . ARG A 1 68 ? -13.53692 -22.57791 14.76257  1.000 40.45064 ? 68  ARG B NH2 1 
ATOM   553  N N   . PRO A 1 69 ? -12.13415 -23.93753 7.08218   1.000 19.37859 ? 69  PRO B N   1 
ATOM   554  C CA  . PRO A 1 69 ? -12.75210 -24.90454 6.15183   1.000 23.01772 ? 69  PRO B CA  1 
ATOM   555  C C   . PRO A 1 69 ? -14.23162 -25.14451 6.41379   1.000 20.77756 ? 69  PRO B C   1 
ATOM   556  O O   . PRO A 1 69 ? -15.03887 -25.14432 5.46973   1.000 17.84126 ? 69  PRO B O   1 
ATOM   557  C CB  . PRO A 1 69 ? -11.92730 -26.18368 6.38005   1.000 22.53343 ? 69  PRO B CB  1 
ATOM   558  C CG  . PRO A 1 69 ? -10.66662 -25.74124 7.03585   1.000 23.33344 ? 69  PRO B CG  1 
ATOM   559  C CD  . PRO A 1 69 ? -11.00841 -24.53000 7.83034   1.000 20.35386 ? 69  PRO B CD  1 
ATOM   560  N N   . GLN A 1 70 ? -14.60868 -25.33414 7.68062   1.000 20.49671 ? 70  GLN B N   1 
ATOM   561  C CA  . GLN A 1 70 ? -15.99030 -25.58455 8.07773   1.000 18.31655 ? 70  GLN B CA  1 
ATOM   562  C C   . GLN A 1 70 ? -16.82144 -24.31314 8.15450   1.000 23.79592 ? 70  GLN B C   1 
ATOM   563  O O   . GLN A 1 70 ? -18.03444 -24.39652 8.39121   1.000 23.71146 ? 70  GLN B O   1 
ATOM   564  C CB  . GLN A 1 70 ? -16.02561 -26.28456 9.44536   1.000 16.68240 ? 70  GLN B CB  1 
ATOM   565  C CG  . GLN A 1 70 ? -15.61677 -25.36488 10.61853  1.000 19.28782 ? 70  GLN B CG  1 
ATOM   566  C CD  . GLN A 1 70 ? -14.09056 -25.33128 10.82742  1.000 25.24153 ? 70  GLN B CD  1 
ATOM   567  O OE1 . GLN A 1 70 ? -13.32380 -25.69725 9.93499   1.000 22.08355 ? 70  GLN B OE1 1 
ATOM   568  N NE2 . GLN A 1 70 ? -13.65706 -24.91044 12.01309  1.000 24.96768 ? 70  GLN B NE2 1 
ATOM   569  N N   . ALA A 1 71 ? -16.20604 -23.13953 7.98724   1.000 20.77846 ? 71  ALA B N   1 
ATOM   570  C CA  . ALA A 1 71 ? -16.93238 -21.86810 8.00520   1.000 19.89926 ? 71  ALA B CA  1 
ATOM   571  C C   . ALA A 1 71 ? -16.15526 -20.85227 7.17619   1.000 21.78374 ? 71  ALA B C   1 
ATOM   572  O O   . ALA A 1 71 ? -15.49490 -19.95090 7.71289   1.000 21.04349 ? 71  ALA B O   1 
ATOM   573  C CB  . ALA A 1 71 ? -17.13456 -21.38651 9.44397   1.000 21.93260 ? 71  ALA B CB  1 
ATOM   574  N N   . PRO A 1 72 ? -16.18707 -20.98370 5.85027   1.000 19.21559 ? 72  PRO B N   1 
ATOM   575  C CA  . PRO A 1 72 ? -15.34037 -20.13300 5.00495   1.000 18.99383 ? 72  PRO B CA  1 
ATOM   576  C C   . PRO A 1 72 ? -15.87699 -18.71437 4.92456   1.000 19.46437 ? 72  PRO B C   1 
ATOM   577  O O   . PRO A 1 72 ? -17.06826 -18.46226 5.11084   1.000 19.82973 ? 72  PRO B O   1 
ATOM   578  C CB  . PRO A 1 72 ? -15.38928 -20.82444 3.63606   1.000 17.52950 ? 72  PRO B CB  1 
ATOM   579  C CG  . PRO A 1 72 ? -16.72499 -21.53006 3.62751   1.000 20.43738 ? 72  PRO B CG  1 
ATOM   580  C CD  . PRO A 1 72 ? -16.93233 -21.98686 5.06682   1.000 19.97525 ? 72  PRO B CD  1 
ATOM   581  N N   . ALA A 1 73 ? -14.97515 -17.77797 4.62675   1.000 17.44347 ? 73  ALA B N   1 
ATOM   582  C CA  . ALA A 1 73 ? -15.37481 -16.38426 4.45460   1.000 18.77957 ? 73  ALA B CA  1 
ATOM   583  C C   . ALA A 1 73 ? -15.91878 -16.15958 3.04827   1.000 15.60166 ? 73  ALA B C   1 
ATOM   584  O O   . ALA A 1 73 ? -15.55284 -16.85339 2.10117   1.000 17.15598 ? 73  ALA B O   1 
ATOM   585  C CB  . ALA A 1 73 ? -14.19744 -15.43445 4.70746   1.000 18.41172 ? 73  ALA B CB  1 
ATOM   586  N N   . THR A 1 74 ? -16.78206 -15.16473 2.91482   1.000 16.07921 ? 74  THR B N   1 
ATOM   587  C CA  . THR A 1 74 ? -17.42257 -14.85297 1.64480   1.000 16.80198 ? 74  THR B CA  1 
ATOM   588  C C   . THR A 1 74 ? -16.68583 -13.70614 0.96213   1.000 19.28807 ? 74  THR B C   1 
ATOM   589  O O   . THR A 1 74 ? -16.41352 -12.67175 1.58232   1.000 17.12174 ? 74  THR B O   1 
ATOM   590  C CB  . THR A 1 74 ? -18.89859 -14.49672 1.84556   1.000 20.43925 ? 74  THR B CB  1 
ATOM   591  O OG1 . THR A 1 74 ? -19.60975 -15.66539 2.29603   1.000 21.00329 ? 74  THR B OG1 1 
ATOM   592  C CG2 . THR A 1 74 ? -19.52414 -13.98898 0.51710   1.000 16.38509 ? 74  THR B CG2 1 
ATOM   593  N N   . VAL A 1 75 ? -16.34714 -13.90573 -0.30819  1.000 17.07371 ? 75  VAL B N   1 
ATOM   594  C CA  . VAL A 1 75 ? -15.79270 -12.86424 -1.16723  1.000 16.36173 ? 75  VAL B CA  1 
ATOM   595  C C   . VAL A 1 75 ? -16.81520 -12.59007 -2.25938  1.000 18.45741 ? 75  VAL B C   1 
ATOM   596  O O   . VAL A 1 75 ? -17.16402 -13.50114 -3.02022  1.000 16.50072 ? 75  VAL B O   1 
ATOM   597  C CB  . VAL A 1 75 ? -14.45664 -13.29533 -1.78926  1.000 18.01715 ? 75  VAL B CB  1 
ATOM   598  C CG1 . VAL A 1 75 ? -13.89394 -12.16781 -2.69056  1.000 15.67301 ? 75  VAL B CG1 1 
ATOM   599  C CG2 . VAL A 1 75 ? -13.48156 -13.72463 -0.71444  1.000 15.15082 ? 75  VAL B CG2 1 
ATOM   600  N N   . GLY A 1 76 ? -17.29433 -11.34717 -2.35188  1.000 15.73516 ? 76  GLY B N   1 
ATOM   601  C CA  . GLY A 1 76 ? -18.18153 -10.99076 -3.44101  1.000 15.61338 ? 76  GLY B CA  1 
ATOM   602  C C   . GLY A 1 76 ? -17.43030 -10.80428 -4.74734  1.000 18.19122 ? 76  GLY B C   1 
ATOM   603  O O   . GLY A 1 76 ? -16.25091 -10.45925 -4.76914  1.000 18.80837 ? 76  GLY B O   1 
ATOM   604  N N   . LEU A 1 77 ? -18.13410 -11.02298 -5.85850  1.000 16.50216 ? 77  LEU B N   1 
ATOM   605  C CA  . LEU A 1 77 ? -17.54297 -10.92589 -7.19251  1.000 16.44276 ? 77  LEU B CA  1 
ATOM   606  C C   . LEU A 1 77 ? -18.50851 -10.24733 -8.15813  1.000 19.06300 ? 77  LEU B C   1 
ATOM   607  O O   . LEU A 1 77 ? -19.67535 -10.63771 -8.24282  1.000 16.53732 ? 77  LEU B O   1 
ATOM   608  C CB  . LEU A 1 77 ? -17.16720 -12.31949 -7.71930  1.000 14.35489 ? 77  LEU B CB  1 
ATOM   609  C CG  . LEU A 1 77 ? -16.93855 -12.42612 -9.22845  1.000 16.86147 ? 77  LEU B CG  1 
ATOM   610  C CD1 . LEU A 1 77 ? -15.68142 -11.64680 -9.63482  1.000 20.28334 ? 77  LEU B CD1 1 
ATOM   611  C CD2 . LEU A 1 77 ? -16.83776 -13.89887 -9.65176  1.000 18.87882 ? 77  LEU B CD2 1 
ATOM   612  N N   . ALA A 1 78 ? -18.02568 -9.23538  -8.88943  1.000 20.31323 ? 78  ALA B N   1 
ATOM   613  C CA  . ALA A 1 78 ? -18.79846 -8.59987  -9.95210  1.000 19.59241 ? 78  ALA B CA  1 
ATOM   614  C C   . ALA A 1 78 ? -17.95108 -8.54166  -11.21583 1.000 23.32779 ? 78  ALA B C   1 
ATOM   615  O O   . ALA A 1 78 ? -16.73537 -8.32232  -11.14695 1.000 21.51860 ? 78  ALA B O   1 
ATOM   616  C CB  . ALA A 1 78 ? -19.26481 -7.18272  -9.56016  1.000 19.70979 ? 78  ALA B CB  1 
ATOM   617  N N   . PHE A 1 79 ? -18.58594 -8.76078  -12.36507 1.000 19.99743 ? 79  PHE B N   1 
ATOM   618  C CA  . PHE A 1 79 ? -17.90568 -8.73401  -13.65467 1.000 20.75866 ? 79  PHE B CA  1 
ATOM   619  C C   . PHE A 1 79 ? -18.10463 -7.37181  -14.32984 1.000 23.97085 ? 79  PHE B C   1 
ATOM   620  O O   . PHE A 1 79 ? -19.10097 -6.68452  -14.09418 1.000 19.49058 ? 79  PHE B O   1 
ATOM   621  C CB  . PHE A 1 79 ? -18.42858 -9.84025  -14.57413 1.000 22.69056 ? 79  PHE B CB  1 
ATOM   622  C CG  . PHE A 1 79 ? -17.96756 -11.25025 -14.20486 1.000 25.14720 ? 79  PHE B CG  1 
ATOM   623  C CD1 . PHE A 1 79 ? -16.71501 -11.48171 -13.65962 1.000 21.09174 ? 79  PHE B CD1 1 
ATOM   624  C CD2 . PHE A 1 79 ? -18.79729 -12.34031 -14.43459 1.000 24.14161 ? 79  PHE B CD2 1 
ATOM   625  C CE1 . PHE A 1 79 ? -16.30735 -12.76405 -13.34012 1.000 19.77592 ? 79  PHE B CE1 1 
ATOM   626  C CE2 . PHE A 1 79 ? -18.38919 -13.63260 -14.12549 1.000 24.54029 ? 79  PHE B CE2 1 
ATOM   627  C CZ  . PHE A 1 79 ? -17.14631 -13.84115 -13.57255 1.000 22.67814 ? 79  PHE B CZ  1 
ATOM   628  N N   . ARG A 1 80 ? -17.14482 -6.98959  -15.17388 1.000 23.18820 ? 80  ARG B N   1 
ATOM   629  C CA  . ARG A 1 80 ? -17.27775 -5.77005  -15.96893 1.000 27.80691 ? 80  ARG B CA  1 
ATOM   630  C C   . ARG A 1 80 ? -18.38805 -5.92533  -17.00330 1.000 27.15627 ? 80  ARG B C   1 
ATOM   631  O O   . ARG A 1 80 ? -18.58263 -7.00707  -17.56479 1.000 27.82027 ? 80  ARG B O   1 
ATOM   632  C CB  . ARG A 1 80 ? -15.95392 -5.44827  -16.66418 1.000 29.12532 ? 80  ARG B CB  1 
ATOM   633  C CG  . ARG A 1 80 ? -15.90388 -4.09168  -17.38140 1.000 28.91926 ? 80  ARG B CG  1 
ATOM   634  C CD  . ARG A 1 80 ? -14.47406 -3.78427  -17.81772 1.000 33.15168 ? 80  ARG B CD  1 
ATOM   635  N NE  . ARG A 1 80 ? -14.09643 -4.53003  -19.01569 1.000 36.73798 ? 80  ARG B NE  1 
ATOM   636  C CZ  . ARG A 1 80 ? -12.86176 -4.59485  -19.49649 1.000 37.39783 ? 80  ARG B CZ  1 
ATOM   637  N NH1 . ARG A 1 80 ? -11.84683 -4.01227  -18.87577 1.000 41.83304 ? 80  ARG B NH1 1 
ATOM   638  N NH2 . ARG A 1 80 ? -12.63701 -5.27161  -20.62019 1.000 36.76068 ? 80  ARG B NH2 1 
ATOM   639  N N   . ALA A 1 81 ? -19.12257 -4.83973  -17.25053 1.000 26.64654 ? 81  ALA B N   1 
ATOM   640  C CA  . ALA A 1 81 ? -20.25045 -4.86848  -18.18570 1.000 26.30131 ? 81  ALA B CA  1 
ATOM   641  C C   . ALA A 1 81 ? -19.80207 -5.21773  -19.59336 1.000 24.72775 ? 81  ALA B C   1 
ATOM   642  O O   . ALA A 1 81 ? -18.66166 -4.92648  -19.96138 1.000 28.77303 ? 81  ALA B O   1 
ATOM   643  C CB  . ALA A 1 81 ? -20.98506 -3.52848  -18.18441 1.000 24.77780 ? 81  ALA B CB  1 
ATOM   644  N N   . PHE A 1 85 ? -18.89804 -1.79223  -14.66998 1.000 24.66645 ? 85  PHE B N   1 
ATOM   645  C CA  . PHE A 1 85 ? -19.12329 -3.02730  -13.89375 1.000 28.63582 ? 85  PHE B CA  1 
ATOM   646  C C   . PHE A 1 85 ? -20.58508 -3.21019  -13.47375 1.000 26.10766 ? 85  PHE B C   1 
ATOM   647  O O   . PHE A 1 85 ? -21.27200 -2.24109  -13.13958 1.000 24.08430 ? 85  PHE B O   1 
ATOM   648  C CB  . PHE A 1 85 ? -18.22577 -3.05605  -12.64595 1.000 24.01923 ? 85  PHE B CB  1 
ATOM   649  C CG  . PHE A 1 85 ? -16.82244 -3.53456  -12.91906 1.000 26.64488 ? 85  PHE B CG  1 
ATOM   650  C CD1 . PHE A 1 85 ? -15.85001 -2.65288  -13.35542 1.000 25.70094 ? 85  PHE B CD1 1 
ATOM   651  C CD2 . PHE A 1 85 ? -16.48151 -4.87002  -12.73628 1.000 24.75611 ? 85  PHE B CD2 1 
ATOM   652  C CE1 . PHE A 1 85 ? -14.55933 -3.09291  -13.61364 1.000 27.64116 ? 85  PHE B CE1 1 
ATOM   653  C CE2 . PHE A 1 85 ? -15.19867 -5.31996  -12.99766 1.000 24.68049 ? 85  PHE B CE2 1 
ATOM   654  C CZ  . PHE A 1 85 ? -14.23432 -4.42738  -13.44102 1.000 28.01797 ? 85  PHE B CZ  1 
ATOM   655  N N   . GLU A 1 86 ? -21.05163 -4.45798  -13.50414 1.000 24.38349 ? 86  GLU B N   1 
ATOM   656  C CA  . GLU A 1 86 ? -22.35408 -4.80096  -12.95177 1.000 25.85734 ? 86  GLU B CA  1 
ATOM   657  C C   . GLU A 1 86 ? -22.37945 -4.50354  -11.45539 1.000 25.15099 ? 86  GLU B C   1 
ATOM   658  O O   . GLU A 1 86 ? -21.33949 -4.44818  -10.78872 1.000 25.15855 ? 86  GLU B O   1 
ATOM   659  C CB  . GLU A 1 86 ? -22.65981 -6.28360  -13.20077 1.000 30.02133 ? 86  GLU B CB  1 
ATOM   660  C CG  . GLU A 1 86 ? -21.79291 -7.23773  -12.36339 1.000 24.13457 ? 86  GLU B CG  1 
ATOM   661  C CD  . GLU A 1 86 ? -21.91920 -8.71734  -12.77302 1.000 28.81357 ? 86  GLU B CD  1 
ATOM   662  O OE1 . GLU A 1 86 ? -22.59763 -9.02514  -13.78012 1.000 23.91510 ? 86  GLU B OE1 1 
ATOM   663  O OE2 . GLU A 1 86 ? -21.32917 -9.57878  -12.07565 1.000 26.12551 ? 86  GLU B OE2 1 
ATOM   664  N N   . ALA A 1 87 ? -23.58103 -4.29426  -10.92031 1.000 23.00964 ? 87  ALA B N   1 
ATOM   665  C CA  . ALA A 1 87 ? -23.70815 -4.17410  -9.47166  1.000 26.22264 ? 87  ALA B CA  1 
ATOM   666  C C   . ALA A 1 87 ? -23.30686 -5.48242  -8.78980  1.000 25.32312 ? 87  ALA B C   1 
ATOM   667  O O   . ALA A 1 87 ? -23.45547 -6.56943  -9.34938  1.000 26.14404 ? 87  ALA B O   1 
ATOM   668  C CB  . ALA A 1 87 ? -25.14146 -3.80989  -9.08126  1.000 27.99951 ? 87  ALA B CB  1 
ATOM   669  N N   . LEU A 1 88 ? -22.78240 -5.37257  -7.57274  1.000 24.03518 ? 88  LEU B N   1 
ATOM   670  C CA  . LEU A 1 88 ? -22.53486 -6.55217  -6.75197  1.000 23.24671 ? 88  LEU B CA  1 
ATOM   671  C C   . LEU A 1 88 ? -23.86980 -7.16666  -6.34846  1.000 22.96743 ? 88  LEU B C   1 
ATOM   672  O O   . LEU A 1 88 ? -24.70819 -6.49654  -5.74036  1.000 22.96230 ? 88  LEU B O   1 
ATOM   673  C CB  . LEU A 1 88 ? -21.72115 -6.18294  -5.51191  1.000 21.65313 ? 88  LEU B CB  1 
ATOM   674  C CG  . LEU A 1 88 ? -21.52868 -7.30678  -4.47675  1.000 25.34338 ? 88  LEU B CG  1 
ATOM   675  C CD1 . LEU A 1 88 ? -20.78338 -8.48600  -5.10322  1.000 20.96939 ? 88  LEU B CD1 1 
ATOM   676  C CD2 . LEU A 1 88 ? -20.79952 -6.80396  -3.21979  1.000 24.27943 ? 88  LEU B CD2 1 
ATOM   677  N N   . CYS A 1 89 ? -24.07667 -8.43591  -6.68661  1.000 19.49618 ? 89  CYS B N   1 
ATOM   678  C CA  . CYS A 1 89 ? -25.36748 -9.07497  -6.44274  1.000 24.80585 ? 89  CYS B CA  1 
ATOM   679  C C   . CYS A 1 89 ? -25.12390 -10.54132 -6.12894  1.000 23.99786 ? 89  CYS B C   1 
ATOM   680  O O   . CYS A 1 89 ? -24.62256 -11.28528 -6.97949  1.000 23.67625 ? 89  CYS B O   1 
ATOM   681  C CB  . CYS A 1 89 ? -26.30876 -8.92703  -7.65040  1.000 27.93507 ? 89  CYS B CB  1 
ATOM   682  S SG  . CYS A 1 89 ? -27.97583 -9.65225  -7.40127  1.000 38.27963 ? 89  CYS B SG  1 
ATOM   683  N N   . ILE A 1 90 ? -25.45583 -10.93903 -4.90686  1.000 23.16829 ? 90  ILE B N   1 
ATOM   684  C CA  . ILE A 1 90 ? -25.31678 -12.31426 -4.44834  1.000 24.36976 ? 90  ILE B CA  1 
ATOM   685  C C   . ILE A 1 90 ? -26.70291 -12.79131 -4.05568  1.000 24.54936 ? 90  ILE B C   1 
ATOM   686  O O   . ILE A 1 90 ? -27.31050 -12.23744 -3.13041  1.000 25.10155 ? 90  ILE B O   1 
ATOM   687  C CB  . ILE A 1 90 ? -24.34610 -12.43565 -3.26048  1.000 21.91452 ? 90  ILE B CB  1 
ATOM   688  C CG1 . ILE A 1 90 ? -22.94863 -11.91019 -3.62232  1.000 21.74514 ? 90  ILE B CG1 1 
ATOM   689  C CG2 . ILE A 1 90 ? -24.26910 -13.88885 -2.78505  1.000 22.22614 ? 90  ILE B CG2 1 
ATOM   690  C CD1 . ILE A 1 90 ? -22.05913 -11.71393 -2.39848  1.000 16.88400 ? 90  ILE B CD1 1 
ATOM   691  N N   . GLU A 1 91 ? -27.20191 -13.80753 -4.74966  1.000 23.37608 ? 91  GLU B N   1 
ATOM   692  C CA  . GLU A 1 91 ? -28.49809 -14.37985 -4.38772  1.000 25.16101 ? 91  GLU B CA  1 
ATOM   693  C C   . GLU A 1 91 ? -28.35902 -15.17967 -3.09920  1.000 22.43152 ? 91  GLU B C   1 
ATOM   694  O O   . GLU A 1 91 ? -27.42389 -15.97369 -2.97058  1.000 23.91255 ? 91  GLU B O   1 
ATOM   695  C CB  . GLU A 1 91 ? -29.02589 -15.27301 -5.50122  1.000 25.64177 ? 91  GLU B CB  1 
ATOM   696  C CG  . GLU A 1 91 ? -29.35565 -14.53051 -6.76963  1.000 32.93464 ? 91  GLU B CG  1 
ATOM   697  C CD  . GLU A 1 91 ? -30.48876 -13.54506 -6.56480  1.000 42.79055 ? 91  GLU B CD  1 
ATOM   698  O OE1 . GLU A 1 91 ? -30.39958 -12.42297 -7.11262  1.000 44.56109 ? 91  GLU B OE1 1 
ATOM   699  O OE2 . GLU A 1 91 ? -31.45690 -13.89400 -5.84455  1.000 43.03213 ? 91  GLU B OE2 1 
ATOM   700  N N   . PRO A 1 92 ? -29.24354 -14.99461 -2.12495  1.000 24.32351 ? 92  PRO B N   1 
ATOM   701  C CA  . PRO A 1 92 ? -29.12660 -15.76578 -0.88204  1.000 22.30618 ? 92  PRO B CA  1 
ATOM   702  C C   . PRO A 1 92 ? -29.45074 -17.23964 -1.10050  1.000 23.60172 ? 92  PRO B C   1 
ATOM   703  O O   . PRO A 1 92 ? -30.16693 -17.61387 -2.03245  1.000 19.69490 ? 92  PRO B O   1 
ATOM   704  C CB  . PRO A 1 92 ? -30.14285 -15.09664 0.05523   1.000 23.61160 ? 92  PRO B CB  1 
ATOM   705  C CG  . PRO A 1 92 ? -31.11350 -14.39258 -0.85247  1.000 26.63893 ? 92  PRO B CG  1 
ATOM   706  C CD  . PRO A 1 92 ? -30.31804 -13.98447 -2.06945  1.000 29.56471 ? 92  PRO B CD  1 
ATOM   707  N N   . PHE A 1 93 ? -28.86479 -18.08546 -0.25161  1.000 20.40996 ? 93  PHE B N   1 
ATOM   708  C CA  . PHE A 1 93 ? -29.27071 -19.47947 -0.19104  1.000 20.64317 ? 93  PHE B CA  1 
ATOM   709  C C   . PHE A 1 93 ? -30.72053 -19.57075 0.28193   1.000 24.23930 ? 93  PHE B C   1 
ATOM   710  O O   . PHE A 1 93 ? -31.30049 -18.60431 0.77621   1.000 22.33596 ? 93  PHE B O   1 
ATOM   711  C CB  . PHE A 1 93 ? -28.35968 -20.26610 0.75190   1.000 22.49115 ? 93  PHE B CB  1 
ATOM   712  C CG  . PHE A 1 93 ? -26.89542 -20.23263 0.36143   1.000 19.51373 ? 93  PHE B CG  1 
ATOM   713  C CD1 . PHE A 1 93 ? -26.51794 -20.30664 -0.96796  1.000 18.86219 ? 93  PHE B CD1 1 
ATOM   714  C CD2 . PHE A 1 93 ? -25.90822 -20.13897 1.32908   1.000 19.70579 ? 93  PHE B CD2 1 
ATOM   715  C CE1 . PHE A 1 93 ? -25.17882 -20.28616 -1.33836  1.000 19.58222 ? 93  PHE B CE1 1 
ATOM   716  C CE2 . PHE A 1 93 ? -24.55879 -20.12041 0.97049   1.000 20.18426 ? 93  PHE B CE2 1 
ATOM   717  C CZ  . PHE A 1 93 ? -24.19777 -20.19219 -0.36716  1.000 15.75233 ? 93  PHE B CZ  1 
ATOM   718  N N   . SER A 1 94 ? -31.30987 -20.75369 0.12116   1.000 22.02479 ? 94  SER B N   1 
ATOM   719  C CA  . SER A 1 94 ? -32.68088 -20.96552 0.56061   1.000 22.89711 ? 94  SER B CA  1 
ATOM   720  C C   . SER A 1 94 ? -32.75451 -21.00600 2.08645   1.000 27.73852 ? 94  SER B C   1 
ATOM   721  O O   . SER A 1 94 ? -31.73884 -20.98904 2.78750   1.000 28.01919 ? 94  SER B O   1 
ATOM   722  C CB  . SER A 1 94 ? -33.22570 -22.26582 -0.02003  1.000 26.01964 ? 94  SER B CB  1 
ATOM   723  O OG  . SER A 1 94 ? -32.38974 -23.34973 0.34672   1.000 23.57403 ? 94  SER B OG  1 
ATOM   724  N N   . SER A 1 95 ? -33.97962 -21.07746 2.60037   1.000 30.53593 ? 95  SER B N   1 
ATOM   725  C CA  . SER A 1 95 ? -34.20931 -21.19362 4.04568   1.000 40.24830 ? 95  SER B CA  1 
ATOM   726  C C   . SER A 1 95 ? -34.77091 -22.56832 4.44258   1.000 38.95070 ? 95  SER B C   1 
ATOM   727  O O   . SER A 1 95 ? -34.73375 -22.96360 5.61415   1.000 42.31370 ? 95  SER B O   1 
ATOM   728  C CB  . SER A 1 95 ? -35.15861 -20.09077 4.50988   1.000 44.76134 ? 95  SER B CB  1 
ATOM   729  O OG  . SER A 1 95 ? -34.68064 -18.82130 4.09662   1.000 47.76662 ? 95  SER B OG  1 
ATOM   730  N N   . MET B 2 1  ? -10.20614 -30.96434 -12.38787 1.000 36.98803 ? 17  MET C N   1 
ATOM   731  C CA  . MET B 2 1  ? -9.78141  -29.97427 -11.39837 1.000 29.36017 ? 17  MET C CA  1 
ATOM   732  C C   . MET B 2 1  ? -10.97235 -29.45846 -10.57052 1.000 27.16544 ? 17  MET C C   1 
ATOM   733  O O   . MET B 2 1  ? -10.93717 -29.55653 -9.35081  1.000 28.03854 ? 17  MET C O   1 
ATOM   734  C CB  . MET B 2 1  ? -9.03699  -28.82452 -12.08184 1.000 32.29227 ? 17  MET C CB  1 
ATOM   735  C CG  . MET B 2 1  ? -8.63278  -27.66554 -11.17384 1.000 39.87261 ? 17  MET C CG  1 
ATOM   736  S SD  . MET B 2 1  ? -7.06877  -27.82175 -10.25893 1.000 66.79691 ? 17  MET C SD  1 
ATOM   737  C CE  . MET B 2 1  ? -7.64125  -28.11071 -8.56855  1.000 42.53159 ? 17  MET C CE  1 
ATOM   738  N N   . TYR B 2 2  ? -12.02901 -28.93931 -11.20134 1.000 22.91892 ? 18  TYR C N   1 
ATOM   739  C CA  . TYR B 2 2  ? -13.22849 -28.51742 -10.47789 1.000 24.63025 ? 18  TYR C CA  1 
ATOM   740  C C   . TYR B 2 2  ? -14.46776 -29.22383 -11.02197 1.000 26.91641 ? 18  TYR C C   1 
ATOM   741  O O   . TYR B 2 2  ? -14.51468 -29.61511 -12.19037 1.000 25.28764 ? 18  TYR C O   1 
ATOM   742  C CB  . TYR B 2 2  ? -13.44160 -26.98855 -10.55127 1.000 20.93934 ? 18  TYR C CB  1 
ATOM   743  C CG  . TYR B 2 2  ? -12.47618 -26.19025 -9.69199  1.000 26.03824 ? 18  TYR C CG  1 
ATOM   744  C CD1 . TYR B 2 2  ? -11.25516 -25.75633 -10.20476 1.000 34.19629 ? 18  TYR C CD1 1 
ATOM   745  C CD2 . TYR B 2 2  ? -12.77729 -25.87202 -8.37097  1.000 24.63950 ? 18  TYR C CD2 1 
ATOM   746  C CE1 . TYR B 2 2  ? -10.35468 -25.03223 -9.42464  1.000 22.40444 ? 18  TYR C CE1 1 
ATOM   747  C CE2 . TYR B 2 2  ? -11.87914 -25.14093 -7.58239  1.000 27.45000 ? 18  TYR C CE2 1 
ATOM   748  C CZ  . TYR B 2 2  ? -10.66342 -24.73134 -8.12948  1.000 29.79734 ? 18  TYR C CZ  1 
ATOM   749  O OH  . TYR B 2 2  ? -9.74992  -24.00771 -7.38057  1.000 38.23054 ? 18  TYR C OH  1 
ATOM   750  N N   . VAL B 2 3  ? -15.48132 -29.38471 -10.16628 1.000 20.09923 ? 19  VAL C N   1 
ATOM   751  C CA  . VAL B 2 3  ? -16.79354 -29.84680 -10.60485 1.000 21.56986 ? 19  VAL C CA  1 
ATOM   752  C C   . VAL B 2 3  ? -17.83666 -28.82390 -10.17735 1.000 22.29655 ? 19  VAL C C   1 
ATOM   753  O O   . VAL B 2 3  ? -17.62806 -28.03619 -9.25267  1.000 21.20131 ? 19  VAL C O   1 
ATOM   754  C CB  . VAL B 2 3  ? -17.16453 -31.23534 -10.04126 1.000 24.36058 ? 19  VAL C CB  1 
ATOM   755  C CG1 . VAL B 2 3  ? -16.16408 -32.31154 -10.48810 1.000 25.17247 ? 19  VAL C CG1 1 
ATOM   756  C CG2 . VAL B 2 3  ? -17.28022 -31.17033 -8.52806  1.000 19.36575 ? 19  VAL C CG2 1 
ATOM   757  N N   . LYS B 2 4  ? -18.99055 -28.87290 -10.83461 1.000 16.55311 ? 20  LYS C N   1 
ATOM   758  C CA  . LYS B 2 4  ? -20.10625 -27.99798 -10.51093 1.000 20.14326 ? 20  LYS C CA  1 
ATOM   759  C C   . LYS B 2 4  ? -21.26955 -28.82606 -9.97379  1.000 21.46692 ? 20  LYS C C   1 
ATOM   760  O O   . LYS B 2 4  ? -21.74218 -29.75233 -10.63984 1.000 23.01720 ? 20  LYS C O   1 
ATOM   761  C CB  . LYS B 2 4  ? -20.52693 -27.19353 -11.73786 1.000 22.00304 ? 20  LYS C CB  1 
ATOM   762  C CG  . LYS B 2 4  ? -21.76848 -26.35256 -11.53448 1.000 22.66676 ? 20  LYS C CG  1 
ATOM   763  C CD  . LYS B 2 4  ? -22.24667 -25.77560 -12.87229 1.000 25.57125 ? 20  LYS C CD  1 
ATOM   764  C CE  . LYS B 2 4  ? -21.21324 -24.82331 -13.45936 1.000 25.58230 ? 20  LYS C CE  1 
ATOM   765  N NZ  . LYS B 2 4  ? -21.80351 -24.03179 -14.59135 1.000 33.00894 ? 20  LYS C NZ  1 
ATOM   766  N N   . LEU B 2 5  ? -21.73136 -28.48355 -8.77955  1.000 17.32928 ? 21  LEU C N   1 
ATOM   767  C CA  . LEU B 2 5  ? -22.84889 -29.15783 -8.13235  1.000 19.84931 ? 21  LEU C CA  1 
ATOM   768  C C   . LEU B 2 5  ? -24.01344 -28.17935 -8.05405  1.000 19.20048 ? 21  LEU C C   1 
ATOM   769  O O   . LEU B 2 5  ? -23.85692 -27.06512 -7.53994  1.000 19.06214 ? 21  LEU C O   1 
ATOM   770  C CB  . LEU B 2 5  ? -22.44442 -29.64908 -6.73924  1.000 19.13879 ? 21  LEU C CB  1 
ATOM   771  C CG  . LEU B 2 5  ? -21.03697 -30.27362 -6.67723  1.000 19.79059 ? 21  LEU C CG  1 
ATOM   772  C CD1 . LEU B 2 5  ? -20.59938 -30.48919 -5.23216  1.000 19.81780 ? 21  LEU C CD1 1 
ATOM   773  C CD2 . LEU B 2 5  ? -20.97151 -31.59758 -7.44960  1.000 18.54732 ? 21  LEU C CD2 1 
ATOM   774  N N   . ILE B 2 6  ? -25.16814 -28.57833 -8.58221  1.000 16.45125 ? 22  ILE C N   1 
ATOM   775  C CA  . ILE B 2 6  ? -26.30539 -27.67700 -8.75702  1.000 19.54039 ? 22  ILE C CA  1 
ATOM   776  C C   . ILE B 2 6  ? -27.41850 -28.10331 -7.80698  1.000 17.91671 ? 22  ILE C C   1 
ATOM   777  O O   . ILE B 2 6  ? -27.85368 -29.25886 -7.82332  1.000 18.03867 ? 22  ILE C O   1 
ATOM   778  C CB  . ILE B 2 6  ? -26.77978 -27.65862 -10.21689 1.000 19.14987 ? 22  ILE C CB  1 
ATOM   779  C CG1 . ILE B 2 6  ? -25.59292 -27.33270 -11.12110 1.000 20.28241 ? 22  ILE C CG1 1 
ATOM   780  C CG2 . ILE B 2 6  ? -27.92393 -26.64292 -10.43025 1.000 14.59257 ? 22  ILE C CG2 1 
ATOM   781  C CD1 . ILE B 2 6  ? -25.96217 -27.27881 -12.60492 1.000 27.02210 ? 22  ILE C CD1 1 
ATOM   782  N N   . SER B 2 7  ? -27.87827 -27.17068 -6.97866  1.000 16.40874 ? 23  SER C N   1 
ATOM   783  C CA  . SER B 2 7  ? -28.87262 -27.48164 -5.96762  1.000 20.17328 ? 23  SER C CA  1 
ATOM   784  C C   . SER B 2 7  ? -30.28017 -27.42832 -6.56639  1.000 19.10447 ? 23  SER C C   1 
ATOM   785  O O   . SER B 2 7  ? -30.48952 -27.01204 -7.71251  1.000 16.28207 ? 23  SER C O   1 
ATOM   786  C CB  . SER B 2 7  ? -28.74913 -26.51331 -4.79071  1.000 15.88476 ? 23  SER C CB  1 
ATOM   787  O OG  . SER B 2 7  ? -29.16066 -25.21565 -5.18703  1.000 19.59923 ? 23  SER C OG  1 
ATOM   788  N N   . SER B 2 8  ? -31.26140 -27.83838 -5.75931  1.000 19.13567 ? 24  SER C N   1 
ATOM   789  C CA  . SER B 2 8  ? -32.63445 -27.92200 -6.25838  1.000 20.97904 ? 24  SER C CA  1 
ATOM   790  C C   . SER B 2 8  ? -33.17386 -26.55816 -6.67940  1.000 23.49491 ? 24  SER C C   1 
ATOM   791  O O   . SER B 2 8  ? -33.94997 -26.47123 -7.63717  1.000 20.13150 ? 24  SER C O   1 
ATOM   792  C CB  . SER B 2 8  ? -33.54424 -28.54963 -5.19729  1.000 20.60139 ? 24  SER C CB  1 
ATOM   793  O OG  . SER B 2 8  ? -33.69082 -27.69110 -4.08357  1.000 21.96891 ? 24  SER C OG  1 
ATOM   794  N N   . ASP B 2 9  ? -32.76116 -25.48232 -6.00060  1.000 20.95912 ? 25  ASP C N   1 
ATOM   795  C CA  . ASP B 2 9  ? -33.17200 -24.12998 -6.35739  1.000 20.88471 ? 25  ASP C CA  1 
ATOM   796  C C   . ASP B 2 9  ? -32.19526 -23.43875 -7.31672  1.000 21.77429 ? 25  ASP C C   1 
ATOM   797  O O   . ASP B 2 9  ? -32.26293 -22.21684 -7.48219  1.000 24.98111 ? 25  ASP C O   1 
ATOM   798  C CB  . ASP B 2 9  ? -33.37094 -23.28023 -5.09432  1.000 22.73438 ? 25  ASP C CB  1 
ATOM   799  C CG  . ASP B 2 9  ? -32.17119 -23.31164 -4.15867  1.000 24.87802 ? 25  ASP C CG  1 
ATOM   800  O OD1 . ASP B 2 9  ? -31.50856 -24.37112 -4.03226  1.000 25.60302 ? 25  ASP C OD1 1 
ATOM   801  O OD2 . ASP B 2 9  ? -31.89057 -22.26812 -3.53004  1.000 24.95312 ? 25  ASP C OD2 1 
ATOM   802  N N   . GLY B 2 10 ? -31.30320 -24.18419 -7.95805  1.000 20.72075 ? 26  GLY C N   1 
ATOM   803  C CA  . GLY B 2 10 ? -30.52192 -23.64569 -9.05322  1.000 20.99275 ? 26  GLY C CA  1 
ATOM   804  C C   . GLY B 2 10 ? -29.22899 -22.94324 -8.69028  1.000 19.14927 ? 26  GLY C C   1 
ATOM   805  O O   . GLY B 2 10 ? -28.61006 -22.35183 -9.57508  1.000 23.88206 ? 26  GLY C O   1 
ATOM   806  N N   . HIS B 2 11 ? -28.79962 -22.98074 -7.43265  1.000 18.04108 ? 27  HIS C N   1 
ATOM   807  C CA  . HIS B 2 11 ? -27.47451 -22.46946 -7.08920  1.000 19.34422 ? 27  HIS C CA  1 
ATOM   808  C C   . HIS B 2 11 ? -26.39886 -23.41913 -7.59598  1.000 17.15808 ? 27  HIS C C   1 
ATOM   809  O O   . HIS B 2 11 ? -26.53888 -24.63752 -7.50788  1.000 18.21605 ? 27  HIS C O   1 
ATOM   810  C CB  . HIS B 2 11 ? -27.33078 -22.29057 -5.57530  1.000 18.59740 ? 27  HIS C CB  1 
ATOM   811  C CG  . HIS B 2 11 ? -27.88840 -21.00017 -5.06343  1.000 22.84894 ? 27  HIS C CG  1 
ATOM   812  N ND1 . HIS B 2 11 ? -27.11658 -19.86796 -4.89684  1.000 19.21494 ? 27  HIS C ND1 1 
ATOM   813  C CD2 . HIS B 2 11 ? -29.14337 -20.66088 -4.68350  1.000 21.86449 ? 27  HIS C CD2 1 
ATOM   814  C CE1 . HIS B 2 11 ? -27.87134 -18.89206 -4.42588  1.000 20.24592 ? 27  HIS C CE1 1 
ATOM   815  N NE2 . HIS B 2 11 ? -29.10567 -19.34463 -4.29506  1.000 23.23916 ? 27  HIS C NE2 1 
ATOM   816  N N   . GLU B 2 12 ? -25.32203 -22.86225 -8.13992  1.000 16.59370 ? 28  GLU C N   1 
ATOM   817  C CA  . GLU B 2 12 ? -24.21602 -23.65143 -8.66637  1.000 17.43203 ? 28  GLU C CA  1 
ATOM   818  C C   . GLU B 2 12 ? -23.02757 -23.53148 -7.72432  1.000 19.36595 ? 28  GLU C C   1 
ATOM   819  O O   . GLU B 2 12 ? -22.54329 -22.42547 -7.45918  1.000 18.82619 ? 28  GLU C O   1 
ATOM   820  C CB  . GLU B 2 12 ? -23.84480 -23.19320 -10.08285 1.000 20.37244 ? 28  GLU C CB  1 
ATOM   821  C CG  . GLU B 2 12 ? -25.07584 -22.90720 -10.91905 1.000 26.59762 ? 28  GLU C CG  1 
ATOM   822  C CD  . GLU B 2 12 ? -24.78777 -22.77559 -12.39428 1.000 33.73821 ? 28  GLU C CD  1 
ATOM   823  O OE1 . GLU B 2 12 ? -23.61501 -22.51262 -12.75936 1.000 32.80177 ? 28  GLU C OE1 1 
ATOM   824  O OE2 . GLU B 2 12 ? -25.74948 -22.94473 -13.18329 1.000 39.00362 ? 28  GLU C OE2 1 
ATOM   825  N N   . PHE B 2 13 ? -22.54580 -24.67011 -7.24684  1.000 19.01683 ? 29  PHE C N   1 
ATOM   826  C CA  . PHE B 2 13 ? -21.42165 -24.74205 -6.32806  1.000 15.13808 ? 29  PHE C CA  1 
ATOM   827  C C   . PHE B 2 13 ? -20.25232 -25.35713 -7.07100  1.000 17.13893 ? 29  PHE C C   1 
ATOM   828  O O   . PHE B 2 13 ? -20.34463 -26.49404 -7.54392  1.000 17.67290 ? 29  PHE C O   1 
ATOM   829  C CB  . PHE B 2 13 ? -21.78862 -25.56688 -5.09190  1.000 14.95551 ? 29  PHE C CB  1 
ATOM   830  C CG  . PHE B 2 13 ? -22.87853 -24.94522 -4.26816  1.000 15.24312 ? 29  PHE C CG  1 
ATOM   831  C CD1 . PHE B 2 13 ? -22.57103 -24.02179 -3.27677  1.000 14.09099 ? 29  PHE C CD1 1 
ATOM   832  C CD2 . PHE B 2 13 ? -24.20761 -25.25013 -4.51185  1.000 15.56489 ? 29  PHE C CD2 1 
ATOM   833  C CE1 . PHE B 2 13 ? -23.57331 -23.41683 -2.52350  1.000 18.69993 ? 29  PHE C CE1 1 
ATOM   834  C CE2 . PHE B 2 13 ? -25.21825 -24.66467 -3.75579  1.000 16.97344 ? 29  PHE C CE2 1 
ATOM   835  C CZ  . PHE B 2 13 ? -24.90890 -23.75202 -2.76436  1.000 15.94939 ? 29  PHE C CZ  1 
ATOM   836  N N   . ILE B 2 14 ? -19.16543 -24.60891 -7.18890  1.000 14.80621 ? 30  ILE C N   1 
ATOM   837  C CA  . ILE B 2 14 ? -17.99337 -25.05824 -7.92935  1.000 16.15921 ? 30  ILE C CA  1 
ATOM   838  C C   . ILE B 2 14 ? -16.92099 -25.43408 -6.91256  1.000 18.31631 ? 30  ILE C C   1 
ATOM   839  O O   . ILE B 2 14 ? -16.48304 -24.59219 -6.11280  1.000 17.38318 ? 30  ILE C O   1 
ATOM   840  C CB  . ILE B 2 14 ? -17.51594 -23.98467 -8.91921  1.000 19.71341 ? 30  ILE C CB  1 
ATOM   841  C CG1 . ILE B 2 14 ? -18.62764 -23.73469 -9.95360  1.000 20.08114 ? 30  ILE C CG1 1 
ATOM   842  C CG2 . ILE B 2 14 ? -16.20265 -24.40533 -9.58483  1.000 17.70423 ? 30  ILE C CG2 1 
ATOM   843  C CD1 . ILE B 2 14 ? -18.38091 -22.53220 -10.83978 1.000 20.86203 ? 30  ILE C CD1 1 
ATOM   844  N N   . VAL B 2 15 ? -16.52415 -26.70314 -6.93150  1.000 13.84692 ? 31  VAL C N   1 
ATOM   845  C CA  . VAL B 2 15 ? -15.73505 -27.32657 -5.87518  1.000 16.25039 ? 31  VAL C CA  1 
ATOM   846  C C   . VAL B 2 15 ? -14.60186 -28.11932 -6.52162  1.000 21.65372 ? 31  VAL C C   1 
ATOM   847  O O   . VAL B 2 15 ? -14.79259 -28.73131 -7.57901  1.000 20.68481 ? 31  VAL C O   1 
ATOM   848  C CB  . VAL B 2 15 ? -16.62047 -28.26395 -5.02169  1.000 19.01977 ? 31  VAL C CB  1 
ATOM   849  C CG1 . VAL B 2 15 ? -15.78815 -29.09121 -4.09430  1.000 24.17515 ? 31  VAL C CG1 1 
ATOM   850  C CG2 . VAL B 2 15 ? -17.66953 -27.46162 -4.25029  1.000 20.64600 ? 31  VAL C CG2 1 
ATOM   851  N N   . LYS B 2 16 ? -13.43733 -28.13385 -5.87689  1.000 20.21850 ? 32  LYS C N   1 
ATOM   852  C CA  . LYS B 2 16 ? -12.34212 -28.97960 -6.33134  1.000 21.31893 ? 32  LYS C CA  1 
ATOM   853  C C   . LYS B 2 16 ? -12.81454 -30.41649 -6.47477  1.000 22.69014 ? 32  LYS C C   1 
ATOM   854  O O   . LYS B 2 16 ? -13.47947 -30.95835 -5.58550  1.000 21.52838 ? 32  LYS C O   1 
ATOM   855  C CB  . LYS B 2 16 ? -11.16377 -28.90855 -5.35301  1.000 21.17157 ? 32  LYS C CB  1 
ATOM   856  C CG  . LYS B 2 16 ? -10.41088 -27.59485 -5.40063  1.000 27.66595 ? 32  LYS C CG  1 
ATOM   857  C CD  . LYS B 2 16 ? -9.33095  -27.52476 -4.32152  1.000 32.82983 ? 32  LYS C CD  1 
ATOM   858  C CE  . LYS B 2 16 ? -8.66456  -26.15187 -4.28590  1.000 32.06387 ? 32  LYS C CE  1 
ATOM   859  N NZ  . LYS B 2 16 ? -7.68353  -26.06069 -3.16907  1.000 36.39538 ? 32  LYS C NZ  1 
ATOM   860  N N   . ARG B 2 17 ? -12.48612 -31.02036 -7.61741  1.000 19.91336 ? 33  ARG C N   1 
ATOM   861  C CA  . ARG B 2 17 ? -12.88760 -32.39820 -7.86994  1.000 23.28125 ? 33  ARG C CA  1 
ATOM   862  C C   . ARG B 2 17 ? -12.42072 -33.32378 -6.75634  1.000 21.22529 ? 33  ARG C C   1 
ATOM   863  O O   . ARG B 2 17 ? -13.16830 -34.20398 -6.31939  1.000 19.54856 ? 33  ARG C O   1 
ATOM   864  C CB  . ARG B 2 17 ? -12.33612 -32.87182 -9.21349  1.000 22.90529 ? 33  ARG C CB  1 
ATOM   865  C CG  . ARG B 2 17 ? -12.69435 -34.31293 -9.53199  1.000 26.60793 ? 33  ARG C CG  1 
ATOM   866  C CD  . ARG B 2 17 ? -12.08339 -34.78501 -10.85649 1.000 32.13269 ? 33  ARG C CD  1 
ATOM   867  N NE  . ARG B 2 17 ? -12.74642 -35.99962 -11.31862 1.000 40.50299 ? 33  ARG C NE  1 
ATOM   868  C CZ  . ARG B 2 17 ? -12.33054 -37.23426 -11.05987 1.000 45.13316 ? 33  ARG C CZ  1 
ATOM   869  N NH1 . ARG B 2 17 ? -11.19053 -37.46443 -10.42245 1.000 35.07764 ? 33  ARG C NH1 1 
ATOM   870  N NH2 . ARG B 2 17 ? -13.07587 -38.26594 -11.45350 1.000 46.01436 ? 33  ARG C NH2 1 
ATOM   871  N N   . GLU B 2 18 ? -11.18908 -33.13896 -6.28296  1.000 22.04307 ? 34  GLU C N   1 
ATOM   872  C CA  . GLU B 2 18 ? -10.66958 -34.00731 -5.22972  1.000 26.02849 ? 34  GLU C CA  1 
ATOM   873  C C   . GLU B 2 18 ? -11.51840 -33.91077 -3.96869  1.000 23.69530 ? 34  GLU C C   1 
ATOM   874  O O   . GLU B 2 18 ? -11.71114 -34.90891 -3.26535  1.000 22.87963 ? 34  GLU C O   1 
ATOM   875  C CB  . GLU B 2 18 ? -9.21083  -33.64944 -4.91837  1.000 29.96858 ? 34  GLU C CB  1 
ATOM   876  C CG  . GLU B 2 18 ? -8.80634  -33.93711 -3.46033  1.000 30.51529 ? 34  GLU C CG  1 
ATOM   877  C CD  . GLU B 2 18 ? -7.49469  -33.27242 -3.03723  1.000 40.93593 ? 34  GLU C CD  1 
ATOM   878  O OE1 . GLU B 2 18 ? -6.87570  -32.55767 -3.86209  1.000 46.14411 ? 34  GLU C OE1 1 
ATOM   879  O OE2 . GLU B 2 18 ? -7.08116  -33.46941 -1.87006  1.000 40.79351 ? 34  GLU C OE2 1 
ATOM   880  N N   . HIS B 2 19 ? -12.03811 -32.71289 -3.66879  1.000 22.43435 ? 35  HIS C N   1 
ATOM   881  C CA  . HIS B 2 19 ? -12.88861 -32.54692 -2.49041  1.000 21.92778 ? 35  HIS C CA  1 
ATOM   882  C C   . HIS B 2 19 ? -14.26595 -33.16726 -2.70610  1.000 20.56506 ? 35  HIS C C   1 
ATOM   883  O O   . HIS B 2 19 ? -14.81202 -33.80493 -1.79916  1.000 17.92652 ? 35  HIS C O   1 
ATOM   884  C CB  . HIS B 2 19 ? -13.02498 -31.06572 -2.13674  1.000 19.09572 ? 35  HIS C CB  1 
ATOM   885  C CG  . HIS B 2 19 ? -11.74517 -30.42081 -1.71167  1.000 22.97469 ? 35  HIS C CG  1 
ATOM   886  N ND1 . HIS B 2 19 ? -11.70967 -29.21399 -1.04851  1.000 22.61571 ? 35  HIS C ND1 1 
ATOM   887  C CD2 . HIS B 2 19 ? -10.45506 -30.80663 -1.86303  1.000 24.11304 ? 35  HIS C CD2 1 
ATOM   888  C CE1 . HIS B 2 19 ? -10.45297 -28.88810 -0.80237  1.000 24.53277 ? 35  HIS C CE1 1 
ATOM   889  N NE2 . HIS B 2 19 ? -9.67234  -29.83640 -1.29030  1.000 23.05223 ? 35  HIS C NE2 1 
ATOM   890  N N   . ALA B 2 20 ? -14.84744 -32.98063 -3.89417  1.000 19.04333 ? 36  ALA C N   1 
ATOM   891  C CA  . ALA B 2 20 ? -16.17454 -33.52764 -4.16212  1.000 19.43596 ? 36  ALA C CA  1 
ATOM   892  C C   . ALA B 2 20 ? -16.18715 -35.04993 -4.05564  1.000 22.25174 ? 36  ALA C C   1 
ATOM   893  O O   . ALA B 2 20 ? -17.21773 -35.63812 -3.69917  1.000 21.10498 ? 36  ALA C O   1 
ATOM   894  C CB  . ALA B 2 20 ? -16.65359 -33.08370 -5.54536  1.000 17.10531 ? 36  ALA C CB  1 
ATOM   895  N N   . LEU B 2 21 ? -15.04908 -35.70021 -4.33980  1.000 23.11430 ? 37  LEU C N   1 
ATOM   896  C CA  . LEU B 2 21 ? -14.92606 -37.15269 -4.26702  1.000 22.99820 ? 37  LEU C CA  1 
ATOM   897  C C   . LEU B 2 21 ? -14.99913 -37.68889 -2.84172  1.000 23.76786 ? 37  LEU C C   1 
ATOM   898  O O   . LEU B 2 21 ? -14.99928 -38.91022 -2.66707  1.000 21.91845 ? 37  LEU C O   1 
ATOM   899  C CB  . LEU B 2 21 ? -13.61040 -37.60980 -4.90587  1.000 26.41635 ? 37  LEU C CB  1 
ATOM   900  C CG  . LEU B 2 21 ? -13.47767 -37.42204 -6.41810  1.000 27.10561 ? 37  LEU C CG  1 
ATOM   901  C CD1 . LEU B 2 21 ? -12.10911 -37.89838 -6.89993  1.000 30.08645 ? 37  LEU C CD1 1 
ATOM   902  C CD2 . LEU B 2 21 ? -14.59291 -38.16531 -7.13187  1.000 27.85731 ? 37  LEU C CD2 1 
ATOM   903  N N   . THR B 2 22 ? -15.03550 -36.81551 -1.82885  1.000 19.97391 ? 38  THR C N   1 
ATOM   904  C CA  . THR B 2 22 ? -15.44001 -37.24271 -0.49411  1.000 20.45374 ? 38  THR C CA  1 
ATOM   905  C C   . THR B 2 22 ? -16.77269 -37.98257 -0.54302  1.000 21.55198 ? 38  THR C C   1 
ATOM   906  O O   . THR B 2 22 ? -17.00586 -38.90763 0.24055   1.000 20.57114 ? 38  THR C O   1 
ATOM   907  C CB  . THR B 2 22 ? -15.55883 -36.02422 0.43428   1.000 21.32031 ? 38  THR C CB  1 
ATOM   908  O OG1 . THR B 2 22 ? -14.32289 -35.29568 0.45660   1.000 19.79106 ? 38  THR C OG1 1 
ATOM   909  C CG2 . THR B 2 22 ? -15.92670 -36.44421 1.84912   1.000 19.51875 ? 38  THR C CG2 1 
ATOM   910  N N   . SER B 2 23 ? -17.65600 -37.58261 -1.45436  1.000 18.82757 ? 39  SER C N   1 
ATOM   911  C CA  . SER B 2 23 ? -18.93444 -38.24674 -1.65060  1.000 19.53889 ? 39  SER C CA  1 
ATOM   912  C C   . SER B 2 23 ? -18.75352 -39.48138 -2.53342  1.000 20.43036 ? 39  SER C C   1 
ATOM   913  O O   . SER B 2 23 ? -18.38286 -39.36210 -3.70512  1.000 19.28238 ? 39  SER C O   1 
ATOM   914  C CB  . SER B 2 23 ? -19.92463 -37.27104 -2.28209  1.000 19.18132 ? 39  SER C CB  1 
ATOM   915  O OG  . SER B 2 23 ? -20.95420 -37.96090 -2.96343  1.000 20.48204 ? 39  SER C OG  1 
ATOM   916  N N   . GLY B 2 24 ? -19.04509 -40.66250 -1.98107  1.000 21.38832 ? 40  GLY C N   1 
ATOM   917  C CA  . GLY B 2 24 ? -19.10137 -41.86087 -2.80633  1.000 20.13239 ? 40  GLY C CA  1 
ATOM   918  C C   . GLY B 2 24 ? -20.07833 -41.74538 -3.96250  1.000 22.82051 ? 40  GLY C C   1 
ATOM   919  O O   . GLY B 2 24 ? -19.83433 -42.28886 -5.04214  1.000 22.44353 ? 40  GLY C O   1 
ATOM   920  N N   . THR B 2 25 ? -21.19238 -41.03065 -3.76561  1.000 20.34069 ? 41  THR C N   1 
ATOM   921  C CA  . THR B 2 25 ? -22.16737 -40.89531 -4.84913  1.000 19.93210 ? 41  THR C CA  1 
ATOM   922  C C   . THR B 2 25 ? -21.61279 -40.03985 -5.99273  1.000 25.44961 ? 41  THR C C   1 
ATOM   923  O O   . THR B 2 25 ? -21.76116 -40.39383 -7.17268  1.000 25.09729 ? 41  THR C O   1 
ATOM   924  C CB  . THR B 2 25 ? -23.48311 -40.31214 -4.31403  1.000 19.22102 ? 41  THR C CB  1 
ATOM   925  O OG1 . THR B 2 25 ? -24.08296 -41.23040 -3.38868  1.000 20.61588 ? 41  THR C OG1 1 
ATOM   926  C CG2 . THR B 2 25 ? -24.47039 -40.02643 -5.45054  1.000 19.95619 ? 41  THR C CG2 1 
ATOM   927  N N   . ILE B 2 26 ? -20.96359 -38.91621 -5.66658  1.000 22.61581 ? 42  ILE C N   1 
ATOM   928  C CA  . ILE B 2 26 ? -20.37532 -38.06929 -6.70244  1.000 23.50895 ? 42  ILE C CA  1 
ATOM   929  C C   . ILE B 2 26 ? -19.29831 -38.83142 -7.46203  1.000 26.37751 ? 42  ILE C C   1 
ATOM   930  O O   . ILE B 2 26 ? -19.21864 -38.75511 -8.69215  1.000 28.37329 ? 42  ILE C O   1 
ATOM   931  C CB  . ILE B 2 26 ? -19.81709 -36.76692 -6.09501  1.000 22.92489 ? 42  ILE C CB  1 
ATOM   932  C CG1 . ILE B 2 26 ? -20.94801 -35.92093 -5.50272  1.000 19.36506 ? 42  ILE C CG1 1 
ATOM   933  C CG2 . ILE B 2 26 ? -19.02827 -35.96947 -7.16617  1.000 22.56165 ? 42  ILE C CG2 1 
ATOM   934  C CD1 . ILE B 2 26 ? -20.48825 -34.56769 -4.96704  1.000 16.80897 ? 42  ILE C CD1 1 
ATOM   935  N N   . LYS B 2 27 ? -18.44750 -39.56735 -6.74432  1.000 23.61814 ? 43  LYS C N   1 
ATOM   936  C CA  . LYS B 2 27 ? -17.41456 -40.36181 -7.40623  1.000 29.28366 ? 43  LYS C CA  1 
ATOM   937  C C   . LYS B 2 27 ? -18.01868 -41.32062 -8.42751  1.000 34.17099 ? 43  LYS C C   1 
ATOM   938  O O   . LYS B 2 27 ? -17.57201 -41.38045 -9.57827  1.000 34.89675 ? 43  LYS C O   1 
ATOM   939  C CB  . LYS B 2 27 ? -16.60912 -41.13870 -6.37101  1.000 30.27733 ? 43  LYS C CB  1 
ATOM   940  C CG  . LYS B 2 27 ? -15.50700 -41.99926 -6.97709  1.000 35.40479 ? 43  LYS C CG  1 
ATOM   941  C CD  . LYS B 2 27 ? -14.84151 -42.83619 -5.90444  1.000 35.26316 ? 43  LYS C CD  1 
ATOM   942  C CE  . LYS B 2 27 ? -14.42711 -41.97316 -4.72546  1.000 36.14164 ? 43  LYS C CE  1 
ATOM   943  N NZ  . LYS B 2 27 ? -13.78851 -42.79180 -3.64469  1.000 48.27671 ? 43  LYS C NZ  1 
ATOM   944  N N   . ALA B 2 28 ? -19.03939 -42.08016 -8.01757  1.000 30.92406 ? 44  ALA C N   1 
ATOM   945  C CA  . ALA B 2 28 ? -19.68393 -43.02246 -8.92528  1.000 31.68299 ? 44  ALA C CA  1 
ATOM   946  C C   . ALA B 2 28 ? -20.36338 -42.30210 -10.08597 1.000 34.14505 ? 44  ALA C C   1 
ATOM   947  O O   . ALA B 2 28 ? -20.29943 -42.76048 -11.23071 1.000 37.43774 ? 44  ALA C O   1 
ATOM   948  C CB  . ALA B 2 28 ? -20.68447 -43.88418 -8.14823  1.000 27.06072 ? 44  ALA C CB  1 
ATOM   949  N N   . MET B 2 29 ? -21.01209 -41.16932 -9.81775  1.000 33.61741 ? 45  MET C N   1 
ATOM   950  C CA  . MET B 2 29 ? -21.67571 -40.43170 -10.88898 1.000 34.65318 ? 45  MET C CA  1 
ATOM   951  C C   . MET B 2 29 ? -20.69074 -39.89811 -11.92513 1.000 40.91206 ? 45  MET C C   1 
ATOM   952  O O   . MET B 2 29 ? -21.04584 -39.75197 -13.10166 1.000 40.95938 ? 45  MET C O   1 
ATOM   953  C CB  . MET B 2 29 ? -22.48601 -39.28131 -10.30503 1.000 33.25375 ? 45  MET C CB  1 
ATOM   954  C CG  . MET B 2 29 ? -23.90322 -39.65140 -10.02811 1.000 36.57073 ? 45  MET C CG  1 
ATOM   955  S SD  . MET B 2 29 ? -24.76126 -38.40087 -9.07661  1.000 48.45333 ? 45  MET C SD  1 
ATOM   956  C CE  . MET B 2 29 ? -26.40613 -38.54944 -9.78059  1.000 45.51020 ? 45  MET C CE  1 
ATOM   957  N N   . LEU B 2 30 ? -19.46514 -39.59300 -11.52089 1.000 41.24013 ? 46  LEU C N   1 
ATOM   958  C CA  . LEU B 2 30 ? -18.48855 -39.03779 -12.44585 1.000 43.95408 ? 46  LEU C CA  1 
ATOM   959  C C   . LEU B 2 30 ? -17.71469 -40.10691 -13.20468 1.000 45.31387 ? 46  LEU C C   1 
ATOM   960  O O   . LEU B 2 30 ? -16.84812 -39.76427 -14.01409 1.000 49.90285 ? 46  LEU C O   1 
ATOM   961  C CB  . LEU B 2 30 ? -17.51081 -38.12958 -11.69514 1.000 39.19903 ? 46  LEU C CB  1 
ATOM   962  C CG  . LEU B 2 30 ? -18.09367 -36.87877 -11.03339 1.000 41.62324 ? 46  LEU C CG  1 
ATOM   963  C CD1 . LEU B 2 30 ? -16.99531 -36.11217 -10.29217 1.000 36.35875 ? 46  LEU C CD1 1 
ATOM   964  C CD2 . LEU B 2 30 ? -18.79953 -35.98727 -12.04778 1.000 43.10982 ? 46  LEU C CD2 1 
ATOM   965  N N   . SER B 2 31 ? -17.99729 -41.38332 -12.96694 1.000 47.19844 ? 47  SER C N   1 
ATOM   966  C CA  . SER B 2 31 ? -17.27392 -42.46623 -13.63503 1.000 48.83264 ? 47  SER C CA  1 
ATOM   967  C C   . SER B 2 31 ? -18.06439 -43.03983 -14.80817 1.000 46.20695 ? 47  SER C C   1 
ATOM   968  O O   . SER B 2 31 ? -17.94670 -42.56828 -15.94235 1.000 54.26858 ? 47  SER C O   1 
ATOM   969  C CB  . SER B 2 31 ? -16.94314 -43.57429 -12.63124 1.000 51.53713 ? 47  SER C CB  1 
ATOM   970  O OG  . SER B 2 31 ? -16.16381 -43.06095 -11.56667 1.000 46.91652 ? 47  SER C OG  1 
ATOM   971  N N   . GLU B 2 40 ? -14.36758 -37.06683 -18.92089 1.000 46.38759 ? 56  GLU C N   1 
ATOM   972  C CA  . GLU B 2 40 ? -15.78048 -37.18661 -18.57021 1.000 46.82383 ? 56  GLU C CA  1 
ATOM   973  C C   . GLU B 2 40 ? -16.36223 -35.84321 -18.10054 1.000 49.01479 ? 56  GLU C C   1 
ATOM   974  O O   . GLU B 2 40 ? -15.63485 -34.85275 -17.96806 1.000 45.37442 ? 56  GLU C O   1 
ATOM   975  C CB  . GLU B 2 40 ? -15.97326 -38.25632 -17.49929 1.000 49.54685 ? 56  GLU C CB  1 
ATOM   976  C CG  . GLU B 2 40 ? -15.99250 -37.72465 -16.08167 1.000 54.97772 ? 56  GLU C CG  1 
ATOM   977  C CD  . GLU B 2 40 ? -14.63446 -37.73802 -15.42350 1.000 57.19683 ? 56  GLU C CD  1 
ATOM   978  O OE1 . GLU B 2 40 ? -13.61612 -37.62335 -16.14778 1.000 62.88183 ? 56  GLU C OE1 1 
ATOM   979  O OE2 . GLU B 2 40 ? -14.59129 -37.86864 -14.17773 1.000 56.86872 ? 56  GLU C OE2 1 
ATOM   980  N N   . THR B 2 41 ? -17.67397 -35.80361 -17.86268 1.000 44.44643 ? 57  THR C N   1 
ATOM   981  C CA  . THR B 2 41 ? -18.35106 -34.54252 -17.58335 1.000 43.73279 ? 57  THR C CA  1 
ATOM   982  C C   . THR B 2 41 ? -18.19580 -34.15242 -16.10814 1.000 42.53826 ? 57  THR C C   1 
ATOM   983  O O   . THR B 2 41 ? -17.80507 -34.95936 -15.25909 1.000 41.81623 ? 57  THR C O   1 
ATOM   984  C CB  . THR B 2 41 ? -19.82683 -34.63334 -17.97854 1.000 40.97400 ? 57  THR C CB  1 
ATOM   985  O OG1 . THR B 2 41 ? -20.45396 -35.69285 -17.24498 1.000 42.89989 ? 57  THR C OG1 1 
ATOM   986  C CG2 . THR B 2 41 ? -19.96197 -34.91452 -19.47562 1.000 44.36079 ? 57  THR C CG2 1 
ATOM   987  N N   . ASN B 2 42 ? -18.51410 -32.88259 -15.80549 1.000 34.70283 ? 58  ASN C N   1 
ATOM   988  C CA  . ASN B 2 42 ? -18.12543 -32.26988 -14.53573 1.000 35.04120 ? 58  ASN C CA  1 
ATOM   989  C C   . ASN B 2 42 ? -19.27788 -31.57125 -13.82713 1.000 28.69359 ? 58  ASN C C   1 
ATOM   990  O O   . ASN B 2 42 ? -19.03706 -30.76496 -12.92913 1.000 25.95682 ? 58  ASN C O   1 
ATOM   991  C CB  . ASN B 2 42 ? -16.98950 -31.26224 -14.74767 1.000 37.03492 ? 58  ASN C CB  1 
ATOM   992  C CG  . ASN B 2 42 ? -15.71726 -31.91943 -15.24651 1.000 48.83149 ? 58  ASN C CG  1 
ATOM   993  O OD1 . ASN B 2 42 ? -15.29539 -32.96593 -14.72790 1.000 49.75577 ? 58  ASN C OD1 1 
ATOM   994  N ND2 . ASN B 2 42 ? -15.10465 -31.32225 -16.27203 1.000 50.55167 ? 58  ASN C ND2 1 
ATOM   995  N N   . GLU B 2 43 ? -20.51249 -31.85751 -14.20577 1.000 23.79613 ? 59  GLU C N   1 
ATOM   996  C CA  . GLU B 2 43 ? -21.68140 -31.17804 -13.67138 1.000 25.96673 ? 59  GLU C CA  1 
ATOM   997  C C   . GLU B 2 43 ? -22.62812 -32.22728 -13.10251 1.000 27.66660 ? 59  GLU C C   1 
ATOM   998  O O   . GLU B 2 43 ? -22.91442 -33.22451 -13.76943 1.000 24.39273 ? 59  GLU C O   1 
ATOM   999  C CB  . GLU B 2 43 ? -22.36701 -30.35664 -14.77276 1.000 27.36207 ? 59  GLU C CB  1 
ATOM   1000 C CG  . GLU B 2 43 ? -23.50567 -29.49853 -14.28174 1.000 35.05738 ? 59  GLU C CG  1 
ATOM   1001 C CD  . GLU B 2 43 ? -24.25156 -28.79895 -15.41076 1.000 42.36186 ? 59  GLU C CD  1 
ATOM   1002 O OE1 . GLU B 2 43 ? -25.27939 -29.33547 -15.88969 1.000 45.32236 ? 59  GLU C OE1 1 
ATOM   1003 O OE2 . GLU B 2 43 ? -23.79642 -27.70057 -15.81386 1.000 39.17028 ? 59  GLU C OE2 1 
ATOM   1004 N N   . VAL B 2 44 ? -23.09493 -32.02771 -11.86883 1.000 21.24167 ? 60  VAL C N   1 
ATOM   1005 C CA  . VAL B 2 44 ? -24.06889 -32.93123 -11.26246 1.000 23.50894 ? 60  VAL C CA  1 
ATOM   1006 C C   . VAL B 2 44 ? -25.21032 -32.10148 -10.70199 1.000 23.01853 ? 60  VAL C C   1 
ATOM   1007 O O   . VAL B 2 44 ? -24.97038 -31.11207 -10.00434 1.000 22.90882 ? 60  VAL C O   1 
ATOM   1008 C CB  . VAL B 2 44 ? -23.44899 -33.81135 -10.15708 1.000 27.24356 ? 60  VAL C CB  1 
ATOM   1009 C CG1 . VAL B 2 44 ? -24.50397 -34.75866 -9.59869  1.000 26.77590 ? 60  VAL C CG1 1 
ATOM   1010 C CG2 . VAL B 2 44 ? -22.26102 -34.61434 -10.69116 1.000 26.60247 ? 60  VAL C CG2 1 
ATOM   1011 N N   . ASN B 2 45 ? -26.44735 -32.50413 -11.00491 1.000 21.72523 ? 61  ASN C N   1 
ATOM   1012 C CA  . ASN B 2 45 ? -27.64786 -31.87713 -10.46257 1.000 21.22786 ? 61  ASN C CA  1 
ATOM   1013 C C   . ASN B 2 45 ? -28.13823 -32.63585 -9.23766  1.000 25.09149 ? 61  ASN C C   1 
ATOM   1014 O O   . ASN B 2 45 ? -28.15735 -33.86920 -9.22780  1.000 25.37139 ? 61  ASN C O   1 
ATOM   1015 C CB  . ASN B 2 45 ? -28.77025 -31.83668 -11.49589 1.000 25.93777 ? 61  ASN C CB  1 
ATOM   1016 C CG  . ASN B 2 45 ? -28.64408 -30.67457 -12.42633 1.000 25.93042 ? 61  ASN C CG  1 
ATOM   1017 O OD1 . ASN B 2 45 ? -29.02397 -29.55435 -12.09182 1.000 30.64079 ? 61  ASN C OD1 1 
ATOM   1018 N ND2 . ASN B 2 45 ? -28.10244 -30.92361 -13.59936 1.000 25.90979 ? 61  ASN C ND2 1 
ATOM   1019 N N   . PHE B 2 46 ? -28.53048 -31.89760 -8.20391  1.000 18.41742 ? 62  PHE C N   1 
ATOM   1020 C CA  . PHE B 2 46 ? -29.13820 -32.48377 -7.00886  1.000 22.61255 ? 62  PHE C CA  1 
ATOM   1021 C C   . PHE B 2 46 ? -30.51712 -31.86234 -6.83575  1.000 19.91422 ? 62  PHE C C   1 
ATOM   1022 O O   . PHE B 2 46 ? -30.70452 -30.95083 -6.03166  1.000 20.91728 ? 62  PHE C O   1 
ATOM   1023 C CB  . PHE B 2 46 ? -28.25622 -32.27465 -5.77179  1.000 19.85134 ? 62  PHE C CB  1 
ATOM   1024 C CG  . PHE B 2 46 ? -26.88843 -32.88029 -5.90323  1.000 22.31643 ? 62  PHE C CG  1 
ATOM   1025 C CD1 . PHE B 2 46 ? -26.71014 -34.24154 -5.80444  1.000 20.78830 ? 62  PHE C CD1 1 
ATOM   1026 C CD2 . PHE B 2 46 ? -25.77788 -32.08404 -6.14093  1.000 25.52340 ? 62  PHE C CD2 1 
ATOM   1027 C CE1 . PHE B 2 46 ? -25.44287 -34.80487 -5.93700  1.000 25.27154 ? 62  PHE C CE1 1 
ATOM   1028 C CE2 . PHE B 2 46 ? -24.51532 -32.64916 -6.26048  1.000 25.50209 ? 62  PHE C CE2 1 
ATOM   1029 C CZ  . PHE B 2 46 ? -24.35170 -34.00761 -6.15669  1.000 22.61152 ? 62  PHE C CZ  1 
ATOM   1030 N N   . ARG B 2 47 ? -31.49213 -32.38201 -7.57728  1.000 17.71806 ? 63  ARG C N   1 
ATOM   1031 C CA  . ARG B 2 47 ? -32.82038 -31.78221 -7.60228  1.000 21.57994 ? 63  ARG C CA  1 
ATOM   1032 C C   . ARG B 2 47 ? -33.60369 -31.95434 -6.30519  1.000 21.72679 ? 63  ARG C C   1 
ATOM   1033 O O   . ARG B 2 47 ? -34.69284 -31.38743 -6.19200  1.000 21.92581 ? 63  ARG C O   1 
ATOM   1034 C CB  . ARG B 2 47 ? -33.62549 -32.35433 -8.76680  1.000 20.99705 ? 63  ARG C CB  1 
ATOM   1035 C CG  . ARG B 2 47 ? -33.10428 -31.87760 -10.10935 1.000 27.40532 ? 63  ARG C CG  1 
ATOM   1036 C CD  . ARG B 2 47 ? -33.97886 -32.34694 -11.26255 1.000 27.95212 ? 63  ARG C CD  1 
ATOM   1037 N NE  . ARG B 2 47 ? -33.40166 -31.93291 -12.53526 1.000 25.44979 ? 63  ARG C NE  1 
ATOM   1038 C CZ  . ARG B 2 47 ? -32.45828 -32.60697 -13.17297 1.000 25.23043 ? 63  ARG C CZ  1 
ATOM   1039 N NH1 . ARG B 2 47 ? -31.99297 -33.75237 -12.70162 1.000 23.17418 ? 63  ARG C NH1 1 
ATOM   1040 N NH2 . ARG B 2 47 ? -31.95233 -32.10844 -14.29857 1.000 29.02274 ? 63  ARG C NH2 1 
ATOM   1041 N N   . GLU B 2 48 ? -33.10514 -32.70376 -5.32741  1.000 19.71278 ? 64  GLU C N   1 
ATOM   1042 C CA  . GLU B 2 48 ? -33.80365 -32.78133 -4.05170  1.000 20.29067 ? 64  GLU C CA  1 
ATOM   1043 C C   . GLU B 2 48 ? -33.02430 -32.15718 -2.89947  1.000 22.92159 ? 64  GLU C C   1 
ATOM   1044 O O   . GLU B 2 48 ? -33.48063 -32.24389 -1.75810  1.000 21.54170 ? 64  GLU C O   1 
ATOM   1045 C CB  . GLU B 2 48 ? -34.14990 -34.24567 -3.72290  1.000 24.44260 ? 64  GLU C CB  1 
ATOM   1046 C CG  . GLU B 2 48 ? -34.46711 -35.12884 -4.95102  1.000 24.56016 ? 64  GLU C CG  1 
ATOM   1047 C CD  . GLU B 2 48 ? -35.77487 -34.77602 -5.65427  1.000 32.87564 ? 64  GLU C CD  1 
ATOM   1048 O OE1 . GLU B 2 48 ? -36.64612 -34.14320 -5.00923  1.000 31.00655 ? 64  GLU C OE1 1 
ATOM   1049 O OE2 . GLU B 2 48 ? -35.92934 -35.14629 -6.85779  1.000 34.68513 ? 64  GLU C OE2 1 
ATOM   1050 N N   . ILE B 2 49 ? -31.88030 -31.51840 -3.15135  1.000 19.51100 ? 65  ILE C N   1 
ATOM   1051 C CA  . ILE B 2 49 ? -31.08693 -30.91322 -2.08481  1.000 18.43159 ? 65  ILE C CA  1 
ATOM   1052 C C   . ILE B 2 49 ? -31.07776 -29.39821 -2.29854  1.000 21.27271 ? 65  ILE C C   1 
ATOM   1053 O O   . ILE B 2 49 ? -30.51888 -28.91667 -3.29708  1.000 21.19865 ? 65  ILE C O   1 
ATOM   1054 C CB  . ILE B 2 49 ? -29.66127 -31.47883 -2.04115  1.000 20.75636 ? 65  ILE C CB  1 
ATOM   1055 C CG1 . ILE B 2 49 ? -29.69327 -33.01510 -1.83253  1.000 21.01585 ? 65  ILE C CG1 1 
ATOM   1056 C CG2 . ILE B 2 49 ? -28.86779 -30.83426 -0.91008  1.000 19.93763 ? 65  ILE C CG2 1 
ATOM   1057 C CD1 . ILE B 2 49 ? -28.32324 -33.67108 -2.02429  1.000 15.84271 ? 65  ILE C CD1 1 
ATOM   1058 N N   . PRO B 2 50 ? -31.66591 -28.61321 -1.39859  1.000 18.80618 ? 66  PRO C N   1 
ATOM   1059 C CA  . PRO B 2 50 ? -31.65478 -27.15544 -1.55633  1.000 20.57272 ? 66  PRO C CA  1 
ATOM   1060 C C   . PRO B 2 50 ? -30.31131 -26.54537 -1.17079  1.000 19.43498 ? 66  PRO C C   1 
ATOM   1061 O O   . PRO B 2 50 ? -29.48953 -27.15392 -0.48077  1.000 20.24120 ? 66  PRO C O   1 
ATOM   1062 C CB  . PRO B 2 50 ? -32.75539 -26.69480 -0.59067  1.000 20.99472 ? 66  PRO C CB  1 
ATOM   1063 C CG  . PRO B 2 50 ? -32.72332 -27.72550 0.49378   1.000 21.18311 ? 66  PRO C CG  1 
ATOM   1064 C CD  . PRO B 2 50 ? -32.34456 -29.03027 -0.15603  1.000 16.31850 ? 66  PRO C CD  1 
ATOM   1065 N N   . SER B 2 51 ? -30.11654 -25.29345 -1.60505  1.000 17.74498 ? 67  SER C N   1 
ATOM   1066 C CA  . SER B 2 51 ? -28.80313 -24.66059 -1.47868  1.000 18.82172 ? 67  SER C CA  1 
ATOM   1067 C C   . SER B 2 51 ? -28.36897 -24.45029 -0.02368  1.000 18.13136 ? 67  SER C C   1 
ATOM   1068 O O   . SER B 2 51 ? -27.16634 -24.52906 0.26528   1.000 15.20389 ? 67  SER C O   1 
ATOM   1069 C CB  . SER B 2 51 ? -28.77738 -23.33080 -2.24467  1.000 19.15758 ? 67  SER C CB  1 
ATOM   1070 O OG  . SER B 2 51 ? -29.78209 -22.44278 -1.80079  1.000 17.27383 ? 67  SER C OG  1 
ATOM   1071 N N   . HIS B 2 52 ? -29.29791 -24.19938 0.91709   1.000 15.75467 ? 68  HIS C N   1 
ATOM   1072 C CA  . HIS B 2 52 ? -28.80571 -24.04851 2.29103   1.000 19.89573 ? 68  HIS C CA  1 
ATOM   1073 C C   . HIS B 2 52 ? -28.24302 -25.35518 2.83688   1.000 19.85243 ? 68  HIS C C   1 
ATOM   1074 O O   . HIS B 2 52 ? -27.39822 -25.31898 3.73946   1.000 20.88646 ? 68  HIS C O   1 
ATOM   1075 C CB  . HIS B 2 52 ? -29.86935 -23.47207 3.25142   1.000 20.44110 ? 68  HIS C CB  1 
ATOM   1076 C CG  . HIS B 2 52 ? -30.97809 -24.41390 3.61261   1.000 22.59571 ? 68  HIS C CG  1 
ATOM   1077 N ND1 . HIS B 2 52 ? -32.09223 -24.59558 2.81829   1.000 24.37976 ? 68  HIS C ND1 1 
ATOM   1078 C CD2 . HIS B 2 52 ? -31.17012 -25.18778 4.70986   1.000 24.56196 ? 68  HIS C CD2 1 
ATOM   1079 C CE1 . HIS B 2 52 ? -32.91143 -25.45587 3.39716   1.000 27.29517 ? 68  HIS C CE1 1 
ATOM   1080 N NE2 . HIS B 2 52 ? -32.37421 -25.83454 4.54446   1.000 26.78168 ? 68  HIS C NE2 1 
ATOM   1081 N N   . VAL B 2 53 ? -28.62944 -26.49481 2.27046   1.000 16.25202 ? 69  VAL C N   1 
ATOM   1082 C CA  . VAL B 2 53 ? -28.05395 -27.77510 2.67332   1.000 14.72278 ? 69  VAL C CA  1 
ATOM   1083 C C   . VAL B 2 53 ? -26.79303 -28.08411 1.88650   1.000 16.13199 ? 69  VAL C C   1 
ATOM   1084 O O   . VAL B 2 53 ? -25.77397 -28.47054 2.46752   1.000 16.70221 ? 69  VAL C O   1 
ATOM   1085 C CB  . VAL B 2 53 ? -29.09321 -28.91356 2.52052   1.000 17.70546 ? 69  VAL C CB  1 
ATOM   1086 C CG1 . VAL B 2 53 ? -28.45639 -30.25248 2.85888   1.000 14.53318 ? 69  VAL C CG1 1 
ATOM   1087 C CG2 . VAL B 2 53 ? -30.34201 -28.64821 3.38543   1.000 17.77277 ? 69  VAL C CG2 1 
ATOM   1088 N N   . LEU B 2 54 ? -26.84372 -27.92535 0.55289   1.000 15.28948 ? 70  LEU C N   1 
ATOM   1089 C CA  . LEU B 2 54 ? -25.69402 -28.27267 -0.28350  1.000 15.06527 ? 70  LEU C CA  1 
ATOM   1090 C C   . LEU B 2 54 ? -24.48126 -27.40110 0.03953   1.000 13.99368 ? 70  LEU C C   1 
ATOM   1091 O O   . LEU B 2 54 ? -23.33789 -27.87291 -0.00928  1.000 13.44003 ? 70  LEU C O   1 
ATOM   1092 C CB  . LEU B 2 54 ? -26.06437 -28.15298 -1.76797  1.000 14.72494 ? 70  LEU C CB  1 
ATOM   1093 C CG  . LEU B 2 54 ? -25.09456 -28.79778 -2.77283  1.000 20.29827 ? 70  LEU C CG  1 
ATOM   1094 C CD1 . LEU B 2 54 ? -24.80404 -30.24099 -2.40862  1.000 17.35494 ? 70  LEU C CD1 1 
ATOM   1095 C CD2 . LEU B 2 54 ? -25.62228 -28.73011 -4.21378  1.000 16.14023 ? 70  LEU C CD2 1 
ATOM   1096 N N   . SER B 2 55 ? -24.70517 -26.12029 0.34196   1.000 12.88056 ? 71  SER C N   1 
ATOM   1097 C CA  . SER B 2 55 ? -23.59472 -25.26531 0.76265   1.000 15.41310 ? 71  SER C CA  1 
ATOM   1098 C C   . SER B 2 55 ? -22.89787 -25.83921 1.99521   1.000 18.09518 ? 71  SER C C   1 
ATOM   1099 O O   . SER B 2 55 ? -21.66246 -25.85592 2.07404   1.000 16.82771 ? 71  SER C O   1 
ATOM   1100 C CB  . SER B 2 55 ? -24.10394 -23.84639 1.04944   1.000 16.86883 ? 71  SER C CB  1 
ATOM   1101 O OG  . SER B 2 55 ? -25.04230 -23.84546 2.10982   1.000 16.65622 ? 71  SER C OG  1 
ATOM   1102 N N   . LYS B 2 56 ? -23.67802 -26.33383 2.96109   1.000 15.08570 ? 72  LYS C N   1 
ATOM   1103 C CA  . LYS B 2 56 ? -23.09319 -26.93571 4.16200   1.000 17.84649 ? 72  LYS C CA  1 
ATOM   1104 C C   . LYS B 2 56 ? -22.36834 -28.23160 3.82215   1.000 15.85995 ? 72  LYS C C   1 
ATOM   1105 O O   . LYS B 2 56 ? -21.34104 -28.56908 4.42641   1.000 16.86549 ? 72  LYS C O   1 
ATOM   1106 C CB  . LYS B 2 56 ? -24.19579 -27.18870 5.20173   1.000 17.56212 ? 72  LYS C CB  1 
ATOM   1107 C CG  . LYS B 2 56 ? -23.70003 -27.46348 6.61460   1.000 22.91997 ? 72  LYS C CG  1 
ATOM   1108 C CD  . LYS B 2 56 ? -23.13658 -26.18488 7.24395   1.000 28.15025 ? 72  LYS C CD  1 
ATOM   1109 C CE  . LYS B 2 56 ? -23.27651 -26.21829 8.74345   1.000 29.10575 ? 72  LYS C CE  1 
ATOM   1110 N NZ  . LYS B 2 56 ? -22.37543 -25.25789 9.42834   1.000 27.41309 ? 72  LYS C NZ  1 
ATOM   1111 N N   . VAL B 2 57 ? -22.89843 -28.98154 2.86387   1.000 15.91072 ? 73  VAL C N   1 
ATOM   1112 C CA  . VAL B 2 57 ? -22.23110 -30.19977 2.43222   1.000 12.81473 ? 73  VAL C CA  1 
ATOM   1113 C C   . VAL B 2 57 ? -20.85735 -29.87812 1.85035   1.000 13.02857 ? 73  VAL C C   1 
ATOM   1114 O O   . VAL B 2 57 ? -19.86706 -30.56666 2.13055   1.000 14.56727 ? 73  VAL C O   1 
ATOM   1115 C CB  . VAL B 2 57 ? -23.13721 -30.93563 1.42700   1.000 13.84987 ? 73  VAL C CB  1 
ATOM   1116 C CG1 . VAL B 2 57 ? -22.38767 -32.06405 0.72959   1.000 12.58151 ? 73  VAL C CG1 1 
ATOM   1117 C CG2 . VAL B 2 57 ? -24.38390 -31.46168 2.15090   1.000 13.65657 ? 73  VAL C CG2 1 
ATOM   1118 N N   . CYS B 2 58 ? -20.77888 -28.82949 1.02172   1.000 15.02607 ? 74  CYS C N   1 
ATOM   1119 C CA  . CYS B 2 58 ? -19.50211 -28.42598 0.43336   1.000 14.63155 ? 74  CYS C CA  1 
ATOM   1120 C C   . CYS B 2 58 ? -18.50354 -27.98853 1.50392   1.000 14.25992 ? 74  CYS C C   1 
ATOM   1121 O O   . CYS B 2 58 ? -17.30041 -28.27183 1.40216   1.000 14.44640 ? 74  CYS C O   1 
ATOM   1122 C CB  . CYS B 2 58 ? -19.73821 -27.30483 -0.57366  1.000 14.47182 ? 74  CYS C CB  1 
ATOM   1123 S SG  . CYS B 2 58 ? -20.61535 -27.86384 -2.07930  1.000 20.04998 ? 74  CYS C SG  1 
ATOM   1124 N N   . MET B 2 59 ? -18.97765 -27.29516 2.53721   1.000 12.62069 ? 75  MET C N   1 
ATOM   1125 C CA  . MET B 2 59 ? -18.09325 -26.98887 3.65829   1.000 15.85343 ? 75  MET C CA  1 
ATOM   1126 C C   . MET B 2 59 ? -17.57164 -28.26679 4.30605   1.000 15.17117 ? 75  MET C C   1 
ATOM   1127 O O   . MET B 2 59 ? -16.40085 -28.33901 4.70250   1.000 17.23461 ? 75  MET C O   1 
ATOM   1128 C CB  . MET B 2 59 ? -18.82733 -26.12209 4.67739   1.000 14.46528 ? 75  MET C CB  1 
ATOM   1129 C CG  . MET B 2 59 ? -19.27375 -24.77334 4.12575   1.000 14.67048 ? 75  MET C CG  1 
ATOM   1130 S SD  . MET B 2 59 ? -20.26126 -23.87617 5.34909   1.000 20.11995 ? 75  MET C SD  1 
ATOM   1131 C CE  . MET B 2 59 ? -21.02183 -22.65685 4.27904   1.000 16.74358 ? 75  MET C CE  1 
ATOM   1132 N N   . TYR B 2 60 ? -18.41836 -29.29935 4.39912   1.000 14.92211 ? 76  TYR C N   1 
ATOM   1133 C CA  . TYR B 2 60 ? -17.96317 -30.56302 4.96652   1.000 14.82467 ? 76  TYR C CA  1 
ATOM   1134 C C   . TYR B 2 60 ? -16.84916 -31.17921 4.12731   1.000 17.46746 ? 76  TYR C C   1 
ATOM   1135 O O   . TYR B 2 60 ? -15.85210 -31.67077 4.67261   1.000 15.62289 ? 76  TYR C O   1 
ATOM   1136 C CB  . TYR B 2 60 ? -19.11760 -31.55595 5.11686   1.000 14.39968 ? 76  TYR C CB  1 
ATOM   1137 C CG  . TYR B 2 60 ? -18.58258 -32.87675 5.63808   1.000 19.44963 ? 76  TYR C CG  1 
ATOM   1138 C CD1 . TYR B 2 60 ? -18.27690 -33.04096 6.98909   1.000 17.08482 ? 76  TYR C CD1 1 
ATOM   1139 C CD2 . TYR B 2 60 ? -18.32739 -33.93975 4.77174   1.000 17.93234 ? 76  TYR C CD2 1 
ATOM   1140 C CE1 . TYR B 2 60 ? -17.75351 -34.24391 7.46664   1.000 15.96412 ? 76  TYR C CE1 1 
ATOM   1141 C CE2 . TYR B 2 60 ? -17.80387 -35.13222 5.23422   1.000 18.73045 ? 76  TYR C CE2 1 
ATOM   1142 C CZ  . TYR B 2 60 ? -17.51204 -35.28456 6.57951   1.000 18.94520 ? 76  TYR C CZ  1 
ATOM   1143 O OH  . TYR B 2 60 ? -16.98580 -36.48742 7.02289   1.000 18.99442 ? 76  TYR C OH  1 
ATOM   1144 N N   . PHE B 2 61 ? -17.02279 -31.20650 2.79704   1.000 15.65695 ? 77  PHE C N   1 
ATOM   1145 C CA  . PHE B 2 61 ? -15.96158 -31.70223 1.91696   1.000 17.14366 ? 77  PHE C CA  1 
ATOM   1146 C C   . PHE B 2 61 ? -14.62415 -31.03097 2.23659   1.000 17.62469 ? 77  PHE C C   1 
ATOM   1147 O O   . PHE B 2 61 ? -13.59525 -31.70003 2.38816   1.000 17.74456 ? 77  PHE C O   1 
ATOM   1148 C CB  . PHE B 2 61 ? -16.29064 -31.43714 0.43991   1.000 16.52607 ? 77  PHE C CB  1 
ATOM   1149 C CG  . PHE B 2 61 ? -17.48762 -32.16348 -0.09529  1.000 17.20632 ? 77  PHE C CG  1 
ATOM   1150 C CD1 . PHE B 2 61 ? -18.01731 -33.29672 0.54196   1.000 16.51724 ? 77  PHE C CD1 1 
ATOM   1151 C CD2 . PHE B 2 61 ? -18.08778 -31.70948 -1.27400  1.000 15.89947 ? 77  PHE C CD2 1 
ATOM   1152 C CE1 . PHE B 2 61 ? -19.13070 -33.95707 0.00629   1.000 16.29554 ? 77  PHE C CE1 1 
ATOM   1153 C CE2 . PHE B 2 61 ? -19.20369 -32.36456 -1.82110  1.000 16.44944 ? 77  PHE C CE2 1 
ATOM   1154 C CZ  . PHE B 2 61 ? -19.72415 -33.49183 -1.18339  1.000 15.22221 ? 77  PHE C CZ  1 
ATOM   1155 N N   . THR B 2 62 ? -14.61793 -29.69353 2.29403   1.000 17.12359 ? 78  THR C N   1 
ATOM   1156 C CA  . THR B 2 62 ? -13.38117 -28.95646 2.56458   1.000 19.55292 ? 78  THR C CA  1 
ATOM   1157 C C   . THR B 2 62 ? -12.77791 -29.37942 3.89856   1.000 19.21962 ? 78  THR C C   1 
ATOM   1158 O O   . THR B 2 62 ? -11.57003 -29.61610 4.01053   1.000 20.00963 ? 78  THR C O   1 
ATOM   1159 C CB  . THR B 2 62 ? -13.65137 -27.44993 2.60081   1.000 20.29305 ? 78  THR C CB  1 
ATOM   1160 O OG1 . THR B 2 62 ? -14.46810 -27.05054 1.48628   1.000 20.15608 ? 78  THR C OG1 1 
ATOM   1161 C CG2 . THR B 2 62 ? -12.33146 -26.68101 2.59144   1.000 18.07071 ? 78  THR C CG2 1 
ATOM   1162 N N   . TYR B 2 63 ? -13.62149 -29.44634 4.92363   1.000 15.27702 ? 79  TYR C N   1 
ATOM   1163 C CA  . TYR B 2 63 ? -13.21254 -29.80137 6.27300   1.000 20.43252 ? 79  TYR C CA  1 
ATOM   1164 C C   . TYR B 2 63 ? -12.74153 -31.24779 6.35023   1.000 21.20769 ? 79  TYR C C   1 
ATOM   1165 O O   . TYR B 2 63 ? -11.72170 -31.54086 6.98827   1.000 19.44453 ? 79  TYR C O   1 
ATOM   1166 C CB  . TYR B 2 63 ? -14.40330 -29.53386 7.19110   1.000 19.64207 ? 79  TYR C CB  1 
ATOM   1167 C CG  . TYR B 2 63 ? -14.41748 -30.12829 8.57584   1.000 21.84577 ? 79  TYR C CG  1 
ATOM   1168 C CD1 . TYR B 2 63 ? -13.91758 -29.41051 9.66263   1.000 19.84164 ? 79  TYR C CD1 1 
ATOM   1169 C CD2 . TYR B 2 63 ? -15.04053 -31.35153 8.82182   1.000 20.13122 ? 79  TYR C CD2 1 
ATOM   1170 C CE1 . TYR B 2 63 ? -13.98905 -29.91430 10.94293  1.000 20.97825 ? 79  TYR C CE1 1 
ATOM   1171 C CE2 . TYR B 2 63 ? -15.11422 -31.87231 10.11166  1.000 19.26133 ? 79  TYR C CE2 1 
ATOM   1172 C CZ  . TYR B 2 63 ? -14.58164 -31.14546 11.16554  1.000 23.71289 ? 79  TYR C CZ  1 
ATOM   1173 O OH  . TYR B 2 63 ? -14.64679 -31.64188 12.44680  1.000 24.84371 ? 79  TYR C OH  1 
ATOM   1174 N N   . LYS B 2 64 ? -13.45991 -32.15944 5.68793   1.000 18.43984 ? 80  LYS C N   1 
ATOM   1175 C CA  . LYS B 2 64 ? -13.05747 -33.56188 5.68668   1.000 18.70495 ? 80  LYS C CA  1 
ATOM   1176 C C   . LYS B 2 64 ? -11.66159 -33.72166 5.09631   1.000 22.58509 ? 80  LYS C C   1 
ATOM   1177 O O   . LYS B 2 64 ? -10.79829 -34.35652 5.70155   1.000 23.50131 ? 80  LYS C O   1 
ATOM   1178 C CB  . LYS B 2 64 ? -14.08610 -34.40633 4.92335   1.000 18.93184 ? 80  LYS C CB  1 
ATOM   1179 C CG  . LYS B 2 64 ? -13.85247 -35.94004 4.97102   1.000 21.89908 ? 80  LYS C CG  1 
ATOM   1180 C CD  . LYS B 2 64 ? -13.55592 -36.43335 6.38609   1.000 27.16506 ? 80  LYS C CD  1 
ATOM   1181 C CE  . LYS B 2 64 ? -13.85081 -37.93361 6.55854   1.000 29.24260 ? 80  LYS C CE  1 
ATOM   1182 N NZ  . LYS B 2 64 ? -12.99268 -38.74952 5.66400   1.000 36.98426 ? 80  LYS C NZ  1 
ATOM   1183 N N   . VAL B 2 65 ? -11.40320 -33.11273 3.93414   1.000 23.74251 ? 81  VAL C N   1 
ATOM   1184 C CA  . VAL B 2 65 ? -10.08622 -33.25489 3.30940   1.000 21.56223 ? 81  VAL C CA  1 
ATOM   1185 C C   . VAL B 2 65 ? -9.00762  -32.59423 4.16716   1.000 23.87472 ? 81  VAL C C   1 
ATOM   1186 O O   . VAL B 2 65 ? -7.94424  -33.17816 4.40586   1.000 22.44281 ? 81  VAL C O   1 
ATOM   1187 C CB  . VAL B 2 65 ? -10.09083 -32.68032 1.87697   1.000 25.05989 ? 81  VAL C CB  1 
ATOM   1188 C CG1 . VAL B 2 65 ? -8.65142  -32.57369 1.35115   1.000 22.76791 ? 81  VAL C CG1 1 
ATOM   1189 C CG2 . VAL B 2 65 ? -10.94299 -33.55495 0.92314   1.000 21.62666 ? 81  VAL C CG2 1 
ATOM   1190 N N   . ARG B 2 66 ? -9.26578  -31.37674 4.65305   1.000 21.11916 ? 82  ARG C N   1 
ATOM   1191 C CA  . ARG B 2 66 ? -8.26274  -30.65258 5.43518   1.000 22.45032 ? 82  ARG C CA  1 
ATOM   1192 C C   . ARG B 2 66 ? -7.85766  -31.39806 6.70912   1.000 27.42938 ? 82  ARG C C   1 
ATOM   1193 O O   . ARG B 2 66 ? -6.69209  -31.33014 7.11629   1.000 26.22004 ? 82  ARG C O   1 
ATOM   1194 C CB  . ARG B 2 66 ? -8.77733  -29.24894 5.77550   1.000 22.85122 ? 82  ARG C CB  1 
ATOM   1195 C CG  . ARG B 2 66 ? -8.04535  -28.52502 6.92170   1.000 29.30609 ? 82  ARG C CG  1 
ATOM   1196 C CD  . ARG B 2 66 ? -6.57466  -28.19095 6.59232   1.000 31.10535 ? 82  ARG C CD  1 
ATOM   1197 N NE  . ARG B 2 66 ? -5.91070  -27.55081 7.72648   1.000 37.09295 ? 82  ARG C NE  1 
ATOM   1198 C CZ  . ARG B 2 66 ? -5.24862  -28.19551 8.68532   1.000 40.39058 ? 82  ARG C CZ  1 
ATOM   1199 N NH1 . ARG B 2 66 ? -5.09066  -29.51305 8.65928   1.000 35.70819 ? 82  ARG C NH1 1 
ATOM   1200 N NH2 . ARG B 2 66 ? -4.73246  -27.50202 9.69951   1.000 40.50876 ? 82  ARG C NH2 1 
ATOM   1201 N N   . TYR B 2 67 ? -8.77266  -32.12769 7.34654   1.000 25.73679 ? 83  TYR C N   1 
ATOM   1202 C CA  . TYR B 2 67 ? -8.46168  -32.70981 8.64885   1.000 24.34625 ? 83  TYR C CA  1 
ATOM   1203 C C   . TYR B 2 67 ? -8.33151  -34.23209 8.63948   1.000 27.39995 ? 83  TYR C C   1 
ATOM   1204 O O   . TYR B 2 67 ? -8.26052  -34.82994 9.71818   1.000 26.86139 ? 83  TYR C O   1 
ATOM   1205 C CB  . TYR B 2 67 ? -9.49927  -32.27643 9.68923   1.000 22.26548 ? 83  TYR C CB  1 
ATOM   1206 C CG  . TYR B 2 67 ? -9.36011  -30.82670 10.08610  1.000 26.25737 ? 83  TYR C CG  1 
ATOM   1207 C CD1 . TYR B 2 67 ? -8.23001  -30.37885 10.76813  1.000 23.91036 ? 83  TYR C CD1 1 
ATOM   1208 C CD2 . TYR B 2 67 ? -10.34403 -29.90333 9.76701   1.000 20.31092 ? 83  TYR C CD2 1 
ATOM   1209 C CE1 . TYR B 2 67 ? -8.08522  -29.03944 11.12295  1.000 24.67510 ? 83  TYR C CE1 1 
ATOM   1210 C CE2 . TYR B 2 67 ? -10.21522 -28.56922 10.12123  1.000 23.93036 ? 83  TYR C CE2 1 
ATOM   1211 C CZ  . TYR B 2 67 ? -9.07819  -28.13908 10.79191  1.000 26.73936 ? 83  TYR C CZ  1 
ATOM   1212 O OH  . TYR B 2 67 ? -8.95063  -26.80925 11.13816  1.000 25.24218 ? 83  TYR C OH  1 
ATOM   1213 N N   . THR B 2 68 ? -8.27977  -34.88106 7.47451   1.000 27.22427 ? 84  THR C N   1 
ATOM   1214 C CA  . THR B 2 68 ? -7.98284  -36.31131 7.47724   1.000 33.74811 ? 84  THR C CA  1 
ATOM   1215 C C   . THR B 2 68 ? -6.53756  -36.52717 7.90808   1.000 33.13783 ? 84  THR C C   1 
ATOM   1216 O O   . THR B 2 68 ? -5.64375  -35.75440 7.54694   1.000 29.04359 ? 84  THR C O   1 
ATOM   1217 C CB  . THR B 2 68 ? -8.20437  -36.96400 6.10614   1.000 38.29304 ? 84  THR C CB  1 
ATOM   1218 O OG1 . THR B 2 68 ? -7.44197  -36.28130 5.11395   1.000 43.15831 ? 84  THR C OG1 1 
ATOM   1219 C CG2 . THR B 2 68 ? -9.66120  -36.96683 5.70488   1.000 29.18735 ? 84  THR C CG2 1 
ATOM   1220 N N   . ASN B 2 69 ? -6.32381  -37.57438 8.70614   1.000 36.57333 ? 85  ASN C N   1 
ATOM   1221 C CA  . ASN B 2 69 ? -5.01150  -37.90303 9.26386   1.000 37.23179 ? 85  ASN C CA  1 
ATOM   1222 C C   . ASN B 2 69 ? -4.40437  -36.70042 9.97814   1.000 35.73253 ? 85  ASN C C   1 
ATOM   1223 O O   . ASN B 2 69 ? -3.26938  -36.29048 9.72405   1.000 37.72996 ? 85  ASN C O   1 
ATOM   1224 C CB  . ASN B 2 69 ? -4.09074  -38.43669 8.17441   1.000 32.83397 ? 85  ASN C CB  1 
ATOM   1225 C CG  . ASN B 2 69 ? -4.62662  -39.70133 7.56392   1.000 38.25757 ? 85  ASN C CG  1 
ATOM   1226 O OD1 . ASN B 2 69 ? -5.24763  -40.51162 8.25607   1.000 36.85951 ? 85  ASN C OD1 1 
ATOM   1227 N ND2 . ASN B 2 69 ? -4.42594  -39.87166 6.26535   1.000 38.11423 ? 85  ASN C ND2 1 
ATOM   1228 N N   . SER B 2 70 ? -5.19013  -36.12705 10.87982  1.000 33.74678 ? 86  SER C N   1 
ATOM   1229 C CA  . SER B 2 70 ? -4.79216  -34.93299 11.60385  1.000 38.98871 ? 86  SER C CA  1 
ATOM   1230 C C   . SER B 2 70 ? -3.78497  -35.27180 12.69703  1.000 41.99294 ? 86  SER C C   1 
ATOM   1231 O O   . SER B 2 70 ? -4.12653  -35.95291 13.66190  1.000 41.99086 ? 86  SER C O   1 
ATOM   1232 C CB  . SER B 2 70 ? -6.01672  -34.24822 12.21279  1.000 32.95217 ? 86  SER C CB  1 
ATOM   1233 O OG  . SER B 2 70 ? -5.73171  -32.88937 12.48516  1.000 38.45111 ? 86  SER C OG  1 
ATOM   1234 N N   . THR B 2 72 ? -3.26265  -34.29007 16.09657  1.000 53.96684 ? 88  THR C N   1 
ATOM   1235 C CA  . THR B 2 72 ? -3.76220  -33.01708 16.61662  1.000 49.72865 ? 88  THR C CA  1 
ATOM   1236 C C   . THR B 2 72 ? -5.28998  -32.96526 16.67188  1.000 54.94793 ? 88  THR C C   1 
ATOM   1237 O O   . THR B 2 72 ? -5.98243  -33.69168 15.94582  1.000 51.92059 ? 88  THR C O   1 
ATOM   1238 C CB  . THR B 2 72 ? -3.26584  -31.82542 15.77680  1.000 50.28605 ? 88  THR C CB  1 
ATOM   1239 O OG1 . THR B 2 72 ? -4.03390  -30.65818 16.09900  1.000 52.45980 ? 88  THR C OG1 1 
ATOM   1240 C CG2 . THR B 2 72 ? -3.38792  -32.12257 14.28554  1.000 52.30809 ? 88  THR C CG2 1 
ATOM   1241 N N   . GLU B 2 73 ? -5.80323  -32.08561 17.53137  1.000 54.55431 ? 89  GLU C N   1 
ATOM   1242 C CA  . GLU B 2 73 ? -7.23821  -31.99977 17.76386  1.000 49.26655 ? 89  GLU C CA  1 
ATOM   1243 C C   . GLU B 2 73 ? -7.94479  -31.34422 16.57960  1.000 46.53622 ? 89  GLU C C   1 
ATOM   1244 O O   . GLU B 2 73 ? -7.43295  -30.40452 15.96263  1.000 44.69172 ? 89  GLU C O   1 
ATOM   1245 C CB  . GLU B 2 73 ? -7.51419  -31.23583 19.06074  1.000 51.27607 ? 89  GLU C CB  1 
ATOM   1246 C CG  . GLU B 2 73 ? -7.11501  -32.02177 20.31570  1.000 61.49960 ? 89  GLU C CG  1 
ATOM   1247 C CD  . GLU B 2 73 ? -7.14270  -31.19127 21.59436  1.000 64.53518 ? 89  GLU C CD  1 
ATOM   1248 O OE1 . GLU B 2 73 ? -6.26974  -30.30749 21.75519  1.000 62.56644 ? 89  GLU C OE1 1 
ATOM   1249 O OE2 . GLU B 2 73 ? -8.03724  -31.42783 22.44166  1.000 66.79831 ? 89  GLU C OE2 1 
ATOM   1250 N N   . ILE B 2 74 ? -9.12335  -31.86159 16.26646  1.000 38.89579 ? 90  ILE C N   1 
ATOM   1251 C CA  . ILE B 2 74 ? -9.88578  -31.48250 15.07987  1.000 31.75369 ? 90  ILE C CA  1 
ATOM   1252 C C   . ILE B 2 74 ? -11.03555 -30.58115 15.52225  1.000 30.37810 ? 90  ILE C C   1 
ATOM   1253 O O   . ILE B 2 74 ? -11.80821 -30.98558 16.39856  1.000 28.10295 ? 90  ILE C O   1 
ATOM   1254 C CB  . ILE B 2 74 ? -10.41924 -32.73259 14.35346  1.000 31.69936 ? 90  ILE C CB  1 
ATOM   1255 C CG1 . ILE B 2 74 ? -9.27608  -33.45463 13.64033  1.000 28.72531 ? 90  ILE C CG1 1 
ATOM   1256 C CG2 . ILE B 2 74 ? -11.55908 -32.39762 13.40051  1.000 30.99485 ? 90  ILE C CG2 1 
ATOM   1257 C CD1 . ILE B 2 74 ? -9.64236  -34.86840 13.20352  1.000 32.99233 ? 90  ILE C CD1 1 
ATOM   1258 N N   . PRO B 2 75 ? -11.19230 -29.38988 14.94993  1.000 29.92266 ? 91  PRO C N   1 
ATOM   1259 C CA  . PRO B 2 75 ? -12.26657 -28.49957 15.40262  1.000 27.85606 ? 91  PRO C CA  1 
ATOM   1260 C C   . PRO B 2 75 ? -13.63991 -29.06279 15.06875  1.000 27.08701 ? 91  PRO C C   1 
ATOM   1261 O O   . PRO B 2 75 ? -13.80188 -29.98221 14.26174  1.000 24.75638 ? 91  PRO C O   1 
ATOM   1262 C CB  . PRO B 2 75 ? -12.00087 -27.19419 14.64422  1.000 25.93119 ? 91  PRO C CB  1 
ATOM   1263 C CG  . PRO B 2 75 ? -11.27878 -27.62165 13.42017  1.000 28.33133 ? 91  PRO C CG  1 
ATOM   1264 C CD  . PRO B 2 75 ? -10.42356 -28.79631 13.84090  1.000 32.00734 ? 91  PRO C CD  1 
ATOM   1265 N N   . GLU B 2 76 ? -14.63808 -28.48224 15.71973  1.000 26.29992 ? 92  GLU C N   1 
ATOM   1266 C CA  . GLU B 2 76 ? -16.00699 -28.94572 15.58528  1.000 28.15733 ? 92  GLU C CA  1 
ATOM   1267 C C   . GLU B 2 76 ? -16.56202 -28.57103 14.21470  1.000 25.30922 ? 92  GLU C C   1 
ATOM   1268 O O   . GLU B 2 76 ? -16.31439 -27.47135 13.70957  1.000 22.51064 ? 92  GLU C O   1 
ATOM   1269 C CB  . GLU B 2 76 ? -16.85590 -28.32342 16.69288  1.000 32.46737 ? 92  GLU C CB  1 
ATOM   1270 C CG  . GLU B 2 76 ? -17.86647 -29.25533 17.32877  1.000 36.47895 ? 92  GLU C CG  1 
ATOM   1271 C CD  . GLU B 2 76 ? -17.22580 -30.42925 18.05702  1.000 49.49377 ? 92  GLU C CD  1 
ATOM   1272 O OE1 . GLU B 2 76 ? -16.11920 -30.25678 18.63339  1.000 49.24495 ? 92  GLU C OE1 1 
ATOM   1273 O OE2 . GLU B 2 76 ? -17.83796 -31.52613 18.05294  1.000 45.28288 ? 92  GLU C OE2 1 
ATOM   1274 N N   . PHE B 2 77 ? -17.31624 -29.48989 13.60515  1.000 22.74842 ? 93  PHE C N   1 
ATOM   1275 C CA  . PHE B 2 77 ? -18.12013 -29.13612 12.44129  1.000 22.54133 ? 93  PHE C CA  1 
ATOM   1276 C C   . PHE B 2 77 ? -19.49200 -28.66769 12.91867  1.000 23.23676 ? 93  PHE C C   1 
ATOM   1277 O O   . PHE B 2 77 ? -20.28717 -29.49868 13.38235  1.000 24.53644 ? 93  PHE C O   1 
ATOM   1278 C CB  . PHE B 2 77 ? -18.26084 -30.30990 11.48150  1.000 21.79287 ? 93  PHE C CB  1 
ATOM   1279 C CG  . PHE B 2 77 ? -18.85338 -29.91716 10.14607  1.000 20.46056 ? 93  PHE C CG  1 
ATOM   1280 C CD1 . PHE B 2 77 ? -18.06165 -29.30350 9.17308   1.000 18.66985 ? 93  PHE C CD1 1 
ATOM   1281 C CD2 . PHE B 2 77 ? -20.19341 -30.11927 9.87964   1.000 18.38758 ? 93  PHE C CD2 1 
ATOM   1282 C CE1 . PHE B 2 77 ? -18.59920 -28.92859 7.94914   1.000 18.86600 ? 93  PHE C CE1 1 
ATOM   1283 C CE2 . PHE B 2 77 ? -20.74432 -29.74383 8.65016   1.000 19.14511 ? 93  PHE C CE2 1 
ATOM   1284 C CZ  . PHE B 2 77 ? -19.94503 -29.14665 7.68743   1.000 15.81430 ? 93  PHE C CZ  1 
ATOM   1285 N N   . PRO B 2 78 ? -19.81120 -27.37464 12.84103  1.000 25.72652 ? 94  PRO C N   1 
ATOM   1286 C CA  . PRO B 2 78 ? -21.05431 -26.88765 13.45966  1.000 26.87133 ? 94  PRO C CA  1 
ATOM   1287 C C   . PRO B 2 78 ? -22.27055 -27.29872 12.64729  1.000 22.70671 ? 94  PRO C C   1 
ATOM   1288 O O   . PRO B 2 78 ? -22.29595 -27.14804 11.42785  1.000 23.50081 ? 94  PRO C O   1 
ATOM   1289 C CB  . PRO B 2 78 ? -20.87332 -25.36382 13.47606  1.000 29.26221 ? 94  PRO C CB  1 
ATOM   1290 C CG  . PRO B 2 78 ? -19.94492 -25.09144 12.34424  1.000 28.72930 ? 94  PRO C CG  1 
ATOM   1291 C CD  . PRO B 2 78 ? -19.00128 -26.27387 12.29045  1.000 26.71507 ? 94  PRO C CD  1 
ATOM   1292 N N   . ILE B 2 79 ? -23.27811 -27.82915 13.33669  1.000 23.85974 ? 95  ILE C N   1 
ATOM   1293 C CA  . ILE B 2 79 ? -24.52279 -28.27291 12.71579  1.000 22.36763 ? 95  ILE C CA  1 
ATOM   1294 C C   . ILE B 2 79 ? -25.66422 -27.80939 13.61218  1.000 20.85591 ? 95  ILE C C   1 
ATOM   1295 O O   . ILE B 2 79 ? -25.88877 -28.38787 14.67831  1.000 23.35072 ? 95  ILE C O   1 
ATOM   1296 C CB  . ILE B 2 79 ? -24.57930 -29.79424 12.52794  1.000 22.30213 ? 95  ILE C CB  1 
ATOM   1297 C CG1 . ILE B 2 79 ? -23.45723 -30.27497 11.59097  1.000 20.29344 ? 95  ILE C CG1 1 
ATOM   1298 C CG2 . ILE B 2 79 ? -25.98423 -30.22464 12.04635  1.000 17.95363 ? 95  ILE C CG2 1 
ATOM   1299 C CD1 . ILE B 2 79 ? -23.45735 -31.78591 11.39125  1.000 19.90377 ? 95  ILE C CD1 1 
ATOM   1300 N N   . ALA B 2 80 ? -26.38503 -26.78526 13.18618  1.000 19.03482 ? 96  ALA C N   1 
ATOM   1301 C CA  . ALA B 2 80 ? -27.53225 -26.33581 13.96048  1.000 24.49811 ? 96  ALA C CA  1 
ATOM   1302 C C   . ALA B 2 80 ? -28.60433 -27.42793 13.99726  1.000 23.52252 ? 96  ALA C C   1 
ATOM   1303 O O   . ALA B 2 80 ? -28.85275 -28.08846 12.97971  1.000 21.00600 ? 96  ALA C O   1 
ATOM   1304 C CB  . ALA B 2 80 ? -28.09421 -25.04254 13.36786  1.000 25.38571 ? 96  ALA C CB  1 
ATOM   1305 N N   . PRO B 2 81 ? -29.24420 -27.65313 15.15393  1.000 26.05456 ? 97  PRO C N   1 
ATOM   1306 C CA  . PRO B 2 81 ? -30.25920 -28.71689 15.25361  1.000 24.88031 ? 97  PRO C CA  1 
ATOM   1307 C C   . PRO B 2 81 ? -31.34595 -28.65309 14.20082  1.000 26.70857 ? 97  PRO C C   1 
ATOM   1308 O O   . PRO B 2 81 ? -31.87243 -29.70191 13.81189  1.000 23.53320 ? 97  PRO C O   1 
ATOM   1309 C CB  . PRO B 2 81 ? -30.85585 -28.50497 16.65452  1.000 29.30857 ? 97  PRO C CB  1 
ATOM   1310 C CG  . PRO B 2 81 ? -29.77068 -27.82756 17.44099  1.000 29.13276 ? 97  PRO C CG  1 
ATOM   1311 C CD  . PRO B 2 81 ? -29.00405 -26.97663 16.44898  1.000 26.92492 ? 97  PRO C CD  1 
ATOM   1312 N N   . GLU B 2 82 ? -31.70293 -27.46366 13.72162  1.000 23.00708 ? 98  GLU C N   1 
ATOM   1313 C CA  . GLU B 2 82 ? -32.85912 -27.34170 12.84780  1.000 25.11794 ? 98  GLU C CA  1 
ATOM   1314 C C   . GLU B 2 82 ? -32.57871 -27.76565 11.41188  1.000 25.05788 ? 98  GLU C C   1 
ATOM   1315 O O   . GLU B 2 82 ? -33.52210 -27.87047 10.62679  1.000 24.94334 ? 98  GLU C O   1 
ATOM   1316 C CB  . GLU B 2 82 ? -33.38281 -25.90349 12.85611  1.000 30.77602 ? 98  GLU C CB  1 
ATOM   1317 C CG  . GLU B 2 82 ? -32.35137 -24.86920 12.39033  1.000 33.43866 ? 98  GLU C CG  1 
ATOM   1318 C CD  . GLU B 2 82 ? -31.69947 -24.11590 13.55326  1.000 40.84992 ? 98  GLU C CD  1 
ATOM   1319 O OE1 . GLU B 2 82 ? -31.50990 -24.71395 14.64374  1.000 31.54778 ? 98  GLU C OE1 1 
ATOM   1320 O OE2 . GLU B 2 82 ? -31.39333 -22.91335 13.37073  1.000 46.55395 ? 98  GLU C OE2 1 
ATOM   1321 N N   . ILE B 2 83 ? -31.32356 -27.98568 11.03297  1.000 22.36466 ? 99  ILE C N   1 
ATOM   1322 C CA  . ILE B 2 83 ? -31.02168 -28.51449 9.70944   1.000 24.66971 ? 99  ILE C CA  1 
ATOM   1323 C C   . ILE B 2 83 ? -30.40749 -29.89733 9.76709   1.000 19.13457 ? 99  ILE C C   1 
ATOM   1324 O O   . ILE B 2 83 ? -30.08989 -30.46035 8.71210   1.000 17.64969 ? 99  ILE C O   1 
ATOM   1325 C CB  . ILE B 2 83 ? -30.11681 -27.55460 8.91538   1.000 26.57870 ? 99  ILE C CB  1 
ATOM   1326 C CG1 . ILE B 2 83 ? -28.88033 -27.20712 9.73100   1.000 25.46733 ? 99  ILE C CG1 1 
ATOM   1327 C CG2 . ILE B 2 83 ? -30.87650 -26.27774 8.60205   1.000 30.67541 ? 99  ILE C CG2 1 
ATOM   1328 C CD1 . ILE B 2 83 ? -27.73238 -28.12694 9.55004   1.000 24.20148 ? 99  ILE C CD1 1 
ATOM   1329 N N   . ALA B 2 84 ? -30.23628 -30.46936 10.96914  1.000 18.37633 ? 100 ALA C N   1 
ATOM   1330 C CA  . ALA B 2 84 ? -29.51045 -31.72796 11.10498  1.000 18.84171 ? 100 ALA C CA  1 
ATOM   1331 C C   . ALA B 2 84 ? -30.16429 -32.83994 10.29286  1.000 17.14616 ? 100 ALA C C   1 
ATOM   1332 O O   . ALA B 2 84 ? -29.46991 -33.61082 9.61896   1.000 17.84426 ? 100 ALA C O   1 
ATOM   1333 C CB  . ALA B 2 84 ? -29.40195 -32.12244 12.58069  1.000 15.91174 ? 100 ALA C CB  1 
ATOM   1334 N N   . LEU B 2 85 ? -31.49881 -32.91904 10.31078  1.000 18.77587 ? 101 LEU C N   1 
ATOM   1335 C CA  . LEU B 2 85 ? -32.17775 -33.99084 9.57840   1.000 19.99119 ? 101 LEU C CA  1 
ATOM   1336 C C   . LEU B 2 85 ? -31.99870 -33.84701 8.06790   1.000 20.21157 ? 101 LEU C C   1 
ATOM   1337 O O   . LEU B 2 85 ? -31.75417 -34.83827 7.36977   1.000 20.31977 ? 101 LEU C O   1 
ATOM   1338 C CB  . LEU B 2 85 ? -33.66259 -34.01946 9.93406   1.000 21.45271 ? 101 LEU C CB  1 
ATOM   1339 C CG  . LEU B 2 85 ? -34.08488 -35.02655 10.99712  1.000 29.69171 ? 101 LEU C CG  1 
ATOM   1340 C CD1 . LEU B 2 85 ? -35.62188 -35.10543 11.09991  1.000 30.21575 ? 101 LEU C CD1 1 
ATOM   1341 C CD2 . LEU B 2 85 ? -33.48128 -36.38492 10.66746  1.000 30.79084 ? 101 LEU C CD2 1 
ATOM   1342 N N   . GLU B 2 86 ? -32.12474 -32.62941 7.53774   1.000 18.32708 ? 102 GLU C N   1 
ATOM   1343 C CA  . GLU B 2 86 ? -31.88782 -32.44988 6.10905   1.000 21.78012 ? 102 GLU C CA  1 
ATOM   1344 C C   . GLU B 2 86 ? -30.44871 -32.77598 5.75046   1.000 18.08147 ? 102 GLU C C   1 
ATOM   1345 O O   . GLU B 2 86 ? -30.17826 -33.38212 4.70958   1.000 18.47102 ? 102 GLU C O   1 
ATOM   1346 C CB  . GLU B 2 86 ? -32.20090 -31.02099 5.69500   1.000 20.87251 ? 102 GLU C CB  1 
ATOM   1347 C CG  . GLU B 2 86 ? -33.62779 -30.62071 5.80678   1.000 23.02045 ? 102 GLU C CG  1 
ATOM   1348 C CD  . GLU B 2 86 ? -33.78542 -29.18655 5.33752   1.000 35.57229 ? 102 GLU C CD  1 
ATOM   1349 O OE1 . GLU B 2 86 ? -33.38943 -28.27841 6.10369   1.000 31.56133 ? 102 GLU C OE1 1 
ATOM   1350 O OE2 . GLU B 2 86 ? -34.24014 -28.97479 4.18254   1.000 36.53943 ? 102 GLU C OE2 1 
ATOM   1351 N N   . LEU B 2 87 ? -29.51007 -32.35791 6.59477   1.000 17.42385 ? 103 LEU C N   1 
ATOM   1352 C CA  . LEU B 2 87 ? -28.10804 -32.66602 6.35775   1.000 17.85693 ? 103 LEU C CA  1 
ATOM   1353 C C   . LEU B 2 87 ? -27.87908 -34.16834 6.36955   1.000 19.25771 ? 103 LEU C C   1 
ATOM   1354 O O   . LEU B 2 87 ? -27.10798 -34.69690 5.56098   1.000 17.82357 ? 103 LEU C O   1 
ATOM   1355 C CB  . LEU B 2 87 ? -27.25094 -31.97603 7.42370   1.000 17.55499 ? 103 LEU C CB  1 
ATOM   1356 C CG  . LEU B 2 87 ? -25.77227 -31.71150 7.15905   1.000 22.68859 ? 103 LEU C CG  1 
ATOM   1357 C CD1 . LEU B 2 87 ? -25.56637 -31.09130 5.76313   1.000 19.00430 ? 103 LEU C CD1 1 
ATOM   1358 C CD2 . LEU B 2 87 ? -25.24157 -30.77816 8.24582   1.000 19.06697 ? 103 LEU C CD2 1 
ATOM   1359 N N   . LEU B 2 88 ? -28.53353 -34.87368 7.29422   1.000 18.10410 ? 104 LEU C N   1 
ATOM   1360 C CA  . LEU B 2 88 ? -28.38627 -36.32183 7.35006   1.000 16.50238 ? 104 LEU C CA  1 
ATOM   1361 C C   . LEU B 2 88 ? -28.90167 -36.96881 6.07649   1.000 14.68213 ? 104 LEU C C   1 
ATOM   1362 O O   . LEU B 2 88 ? -28.28917 -37.90545 5.55200   1.000 17.67562 ? 104 LEU C O   1 
ATOM   1363 C CB  . LEU B 2 88 ? -29.12827 -36.87394 8.56719   1.000 14.25018 ? 104 LEU C CB  1 
ATOM   1364 C CG  . LEU B 2 88 ? -29.31584 -38.39718 8.59974   1.000 20.90514 ? 104 LEU C CG  1 
ATOM   1365 C CD1 . LEU B 2 88 ? -27.97891 -39.13754 8.58625   1.000 14.91875 ? 104 LEU C CD1 1 
ATOM   1366 C CD2 . LEU B 2 88 ? -30.15003 -38.80113 9.82697   1.000 22.54732 ? 104 LEU C CD2 1 
ATOM   1367 N N   . MET B 2 89 ? -30.03183 -36.49248 5.56722   1.000 15.01850 ? 105 MET C N   1 
ATOM   1368 C CA  . MET B 2 89 ? -30.58957 -37.11703 4.37641   1.000 19.30522 ? 105 MET C CA  1 
ATOM   1369 C C   . MET B 2 89 ? -29.73440 -36.82234 3.15640   1.000 19.62927 ? 105 MET C C   1 
ATOM   1370 O O   . MET B 2 89 ? -29.55765 -37.68959 2.29385   1.000 20.29441 ? 105 MET C O   1 
ATOM   1371 C CB  . MET B 2 89 ? -32.03236 -36.66018 4.18416   1.000 19.31959 ? 105 MET C CB  1 
ATOM   1372 C CG  . MET B 2 89 ? -32.96155 -37.35843 5.18738   1.000 28.60893 ? 105 MET C CG  1 
ATOM   1373 S SD  . MET B 2 89 ? -34.69600 -36.98673 4.92170   1.000 38.13535 ? 105 MET C SD  1 
ATOM   1374 C CE  . MET B 2 89 ? -34.70456 -35.21296 5.20842   1.000 22.70780 ? 105 MET C CE  1 
ATOM   1375 N N   . ALA B 2 90 ? -29.16065 -35.61662 3.08872   1.000 18.33378 ? 106 ALA C N   1 
ATOM   1376 C CA  . ALA B 2 90 ? -28.18824 -35.32499 2.04068   1.000 19.34197 ? 106 ALA C CA  1 
ATOM   1377 C C   . ALA B 2 90 ? -26.96746 -36.23108 2.15370   1.000 15.59735 ? 106 ALA C C   1 
ATOM   1378 O O   . ALA B 2 90 ? -26.49538 -36.76847 1.15203   1.000 16.98571 ? 106 ALA C O   1 
ATOM   1379 C CB  . ALA B 2 90 ? -27.77241 -33.85320 2.10784   1.000 18.82664 ? 106 ALA C CB  1 
ATOM   1380 N N   . ALA B 2 91 ? -26.44240 -36.41396 3.36920   1.000 16.39705 ? 107 ALA C N   1 
ATOM   1381 C CA  . ALA B 2 91 ? -25.27302 -37.26590 3.55784   1.000 15.76595 ? 107 ALA C CA  1 
ATOM   1382 C C   . ALA B 2 91 ? -25.59053 -38.73619 3.30354   1.000 16.50165 ? 107 ALA C C   1 
ATOM   1383 O O   . ALA B 2 91 ? -24.70342 -39.49411 2.89922   1.000 14.60533 ? 107 ALA C O   1 
ATOM   1384 C CB  . ALA B 2 91 ? -24.71436 -37.09184 4.97278   1.000 17.75892 ? 107 ALA C CB  1 
ATOM   1385 N N   . ASN B 2 92 ? -26.82523 -39.16622 3.57755   1.000 16.18503 ? 108 ASN C N   1 
ATOM   1386 C CA  . ASN B 2 92 ? -27.24186 -40.51371 3.19006   1.000 16.75092 ? 108 ASN C CA  1 
ATOM   1387 C C   . ASN B 2 92 ? -27.17411 -40.67708 1.67583   1.000 17.20753 ? 108 ASN C C   1 
ATOM   1388 O O   . ASN B 2 92 ? -26.54622 -41.61151 1.16711   1.000 18.22070 ? 108 ASN C O   1 
ATOM   1389 C CB  . ASN B 2 92 ? -28.66516 -40.80168 3.69154   1.000 16.29048 ? 108 ASN C CB  1 
ATOM   1390 C CG  . ASN B 2 92 ? -28.71728 -41.07159 5.19672   1.000 20.99154 ? 108 ASN C CG  1 
ATOM   1391 O OD1 . ASN B 2 92 ? -27.69889 -41.36551 5.81641   1.000 18.63047 ? 108 ASN C OD1 1 
ATOM   1392 N ND2 . ASN B 2 92 ? -29.91329 -40.98205 5.78071   1.000 18.01888 ? 108 ASN C ND2 1 
ATOM   1393 N N   . PHE B 2 93 ? -27.81397 -39.76407 0.94014   1.000 14.90683 ? 109 PHE C N   1 
ATOM   1394 C CA  . PHE B 2 93 ? -27.80821 -39.85476 -0.51673  1.000 19.68565 ? 109 PHE C CA  1 
ATOM   1395 C C   . PHE B 2 93 ? -26.39320 -39.76217 -1.07260  1.000 19.98741 ? 109 PHE C C   1 
ATOM   1396 O O   . PHE B 2 93 ? -26.01086 -40.55094 -1.94354  1.000 17.53651 ? 109 PHE C O   1 
ATOM   1397 C CB  . PHE B 2 93 ? -28.68612 -38.76148 -1.13215  1.000 18.57472 ? 109 PHE C CB  1 
ATOM   1398 C CG  . PHE B 2 93 ? -28.56391 -38.67442 -2.62196  1.000 19.93925 ? 109 PHE C CG  1 
ATOM   1399 C CD1 . PHE B 2 93 ? -29.15063 -39.64384 -3.43478  1.000 21.44798 ? 109 PHE C CD1 1 
ATOM   1400 C CD2 . PHE B 2 93 ? -27.83553 -37.64880 -3.21823  1.000 19.30926 ? 109 PHE C CD2 1 
ATOM   1401 C CE1 . PHE B 2 93 ? -29.03053 -39.58893 -4.83508  1.000 21.94416 ? 109 PHE C CE1 1 
ATOM   1402 C CE2 . PHE B 2 93 ? -27.71395 -37.57671 -4.61539  1.000 20.98256 ? 109 PHE C CE2 1 
ATOM   1403 C CZ  . PHE B 2 93 ? -28.31958 -38.55091 -5.41980  1.000 21.41249 ? 109 PHE C CZ  1 
ATOM   1404 N N   . LEU B 2 94 ? -25.58972 -38.82419 -0.55724  1.000 18.40558 ? 110 LEU C N   1 
ATOM   1405 C CA  . LEU B 2 94 ? -24.24451 -38.58963 -1.08597  1.000 17.16590 ? 110 LEU C CA  1 
ATOM   1406 C C   . LEU B 2 94 ? -23.21051 -39.60923 -0.62614  1.000 20.79734 ? 110 LEU C C   1 
ATOM   1407 O O   . LEU B 2 94 ? -22.12710 -39.67304 -1.22926  1.000 21.75704 ? 110 LEU C O   1 
ATOM   1408 C CB  . LEU B 2 94 ? -23.76432 -37.19241 -0.69415  1.000 17.52280 ? 110 LEU C CB  1 
ATOM   1409 C CG  . LEU B 2 94 ? -24.60037 -36.08209 -1.32585  1.000 15.80478 ? 110 LEU C CG  1 
ATOM   1410 C CD1 . LEU B 2 94 ? -24.28410 -34.78534 -0.63519  1.000 17.82808 ? 110 LEU C CD1 1 
ATOM   1411 C CD2 . LEU B 2 94 ? -24.29294 -35.99162 -2.81556  1.000 19.27156 ? 110 LEU C CD2 1 
ATOM   1412 N N   . ASP B 2 95 ? -23.50713 -40.39337 0.41290   1.000 19.46720 ? 111 ASP C N   1 
ATOM   1413 C CA  . ASP B 2 95 ? -22.54758 -41.32902 1.00684   1.000 20.82270 ? 111 ASP C CA  1 
ATOM   1414 C C   . ASP B 2 95 ? -21.25462 -40.60544 1.39876   1.000 23.58985 ? 111 ASP C C   1 
ATOM   1415 O O   . ASP B 2 95 ? -20.15245 -40.93233 0.94374   1.000 21.49158 ? 111 ASP C O   1 
ATOM   1416 C CB  . ASP B 2 95 ? -22.26101 -42.50610 0.06768   1.000 22.81168 ? 111 ASP C CB  1 
ATOM   1417 C CG  . ASP B 2 95 ? -21.35528 -43.56051 0.69722   1.000 25.14297 ? 111 ASP C CG  1 
ATOM   1418 O OD1 . ASP B 2 95 ? -21.20287 -43.56618 1.93254   1.000 28.81048 ? 111 ASP C OD1 1 
ATOM   1419 O OD2 . ASP B 2 95 ? -20.77567 -44.37011 -0.05177  1.000 29.22724 ? 111 ASP C OD2 1 
ATOM   1420 N N   . CYS B 2 96 ? -21.40972 -39.60565 2.26634   1.000 22.87011 ? 112 CYS C N   1 
ATOM   1421 C CA  . CYS B 2 96 ? -20.25200 -38.93074 2.85468   1.000 25.84207 ? 112 CYS C CA  1 
ATOM   1422 C C   . CYS B 2 96 ? -20.41428 -38.71260 4.37502   1.000 26.02994 ? 112 CYS C C   1 
ATOM   1423 O O   . CYS B 2 96 ? -21.40956 -39.11367 4.99958   1.000 21.76407 ? 112 CYS C O   1 
ATOM   1424 C CB  . CYS B 2 96 ? -20.00547 -37.59274 2.14954   1.000 20.46049 ? 112 CYS C CB  1 
ATOM   1425 S SG  . CYS B 2 96 ? -21.30205 -36.39945 2.40589   1.000 27.75288 ? 112 CYS C SG  1 
ATOM   1426 O OXT . CYS B 2 96 ? -19.53389 -38.12853 5.02362   1.000 24.04103 ? 112 CYS C OXT 1 
ATOM   1427 N N   . PHE C 3 11 ? -5.98924  -39.74985 13.01184  1.000 43.56614 ? 35  PHE A N   1 
ATOM   1428 C CA  . PHE C 3 11 ? -7.37876  -39.36391 13.28061  1.000 42.82971 ? 35  PHE A CA  1 
ATOM   1429 C C   . PHE C 3 11 ? -7.97694  -38.50866 12.15404  1.000 36.97059 ? 35  PHE A C   1 
ATOM   1430 O O   . PHE C 3 11 ? -7.38914  -37.50897 11.74237  1.000 34.46737 ? 35  PHE A O   1 
ATOM   1431 C CB  . PHE C 3 11 ? -7.47403  -38.60680 14.61299  1.000 37.84821 ? 35  PHE A CB  1 
ATOM   1432 C CG  . PHE C 3 11 ? -7.17705  -39.45885 15.81847  1.000 39.60532 ? 35  PHE A CG  1 
ATOM   1433 N N   . SER C 3 12 ? -9.14808  -38.90491 11.66941  1.000 34.12425 ? 36  SER A N   1 
ATOM   1434 C CA  . SER C 3 12 ? -9.89755  -38.19128 10.64660  1.000 34.82766 ? 36  SER A CA  1 
ATOM   1435 C C   . SER C 3 12 ? -11.28070 -37.81706 11.16856  1.000 30.85475 ? 36  SER A C   1 
ATOM   1436 O O   . SER C 3 12 ? -11.78861 -38.44180 12.10688  1.000 29.46664 ? 36  SER A O   1 
ATOM   1437 C CB  . SER C 3 12 ? -10.04088 -39.04365 9.37677   1.000 33.54785 ? 36  SER A CB  1 
ATOM   1438 O OG  . SER C 3 12 ? -8.79029  -39.22658 8.73239   1.000 38.28330 ? 36  SER A OG  1 
ATOM   1439 N N   . PRO C 3 13 ? -11.91852 -36.79867 10.59216  1.000 27.64855 ? 37  PRO A N   1 
ATOM   1440 C CA  . PRO C 3 13 ? -13.28204 -36.46330 11.02277  1.000 26.25878 ? 37  PRO A CA  1 
ATOM   1441 C C   . PRO C 3 13 ? -14.24200 -37.61569 10.75703  1.000 25.25376 ? 37  PRO A C   1 
ATOM   1442 O O   . PRO C 3 13 ? -14.06053 -38.39978 9.82443   1.000 22.97158 ? 37  PRO A O   1 
ATOM   1443 C CB  . PRO C 3 13 ? -13.63635 -35.23796 10.17246  1.000 24.62543 ? 37  PRO A CB  1 
ATOM   1444 C CG  . PRO C 3 13 ? -12.29254 -34.66218 9.74139   1.000 28.74470 ? 37  PRO A CG  1 
ATOM   1445 C CD  . PRO C 3 13 ? -11.40248 -35.85900 9.58104   1.000 26.10153 ? 37  PRO A CD  1 
ATOM   1446 N N   . LEU C 3 14 ? -15.27095 -37.71321 11.59810  1.000 24.44217 ? 38  LEU A N   1 
ATOM   1447 C CA  . LEU C 3 14 ? -16.36445 -38.64758 11.34561  1.000 23.38899 ? 38  LEU A CA  1 
ATOM   1448 C C   . LEU C 3 14 ? -17.08702 -38.27644 10.05124  1.000 23.53810 ? 38  LEU A C   1 
ATOM   1449 O O   . LEU C 3 14 ? -17.08267 -37.11642 9.61820   1.000 19.91894 ? 38  LEU A O   1 
ATOM   1450 C CB  . LEU C 3 14 ? -17.36741 -38.63386 12.51020  1.000 27.63780 ? 38  LEU A CB  1 
ATOM   1451 C CG  . LEU C 3 14 ? -17.12715 -39.32462 13.86983  1.000 31.61422 ? 38  LEU A CG  1 
ATOM   1452 C CD1 . LEU C 3 14 ? -15.75849 -39.02031 14.43545  1.000 32.45258 ? 38  LEU A CD1 1 
ATOM   1453 C CD2 . LEU C 3 14 ? -18.21330 -38.91115 14.87169  1.000 29.41450 ? 38  LEU A CD2 1 
ATOM   1454 N N   . CYS C 3 15 ? -17.71491 -39.26873 9.42615   1.000 20.12022 ? 39  CYS A N   1 
ATOM   1455 C CA  . CYS C 3 15 ? -18.49033 -38.97916 8.22919   1.000 20.11040 ? 39  CYS A CA  1 
ATOM   1456 C C   . CYS C 3 15 ? -19.68906 -38.10264 8.59120   1.000 22.61912 ? 39  CYS A C   1 
ATOM   1457 O O   . CYS C 3 15 ? -20.11555 -38.03372 9.75206   1.000 17.04137 ? 39  CYS A O   1 
ATOM   1458 C CB  . CYS C 3 15 ? -18.95411 -40.26629 7.55500   1.000 22.26623 ? 39  CYS A CB  1 
ATOM   1459 S SG  . CYS C 3 15 ? -20.15834 -41.19641 8.53481   1.000 30.99303 ? 39  CYS A SG  1 
ATOM   1460 N N   . LEU C 3 16 ? -20.22028 -37.40761 7.58024   1.000 16.49008 ? 40  LEU A N   1 
ATOM   1461 C CA  . LEU C 3 16 ? -21.28238 -36.43863 7.83442   1.000 18.71350 ? 40  LEU A CA  1 
ATOM   1462 C C   . LEU C 3 16 ? -22.57660 -37.10915 8.29026   1.000 17.22748 ? 40  LEU A C   1 
ATOM   1463 O O   . LEU C 3 16 ? -23.34305 -36.50229 9.04494   1.000 17.48512 ? 40  LEU A O   1 
ATOM   1464 C CB  . LEU C 3 16 ? -21.52524 -35.58517 6.58768   1.000 16.46572 ? 40  LEU A CB  1 
ATOM   1465 C CG  . LEU C 3 16 ? -22.54262 -34.44762 6.66321   1.000 17.91311 ? 40  LEU A CG  1 
ATOM   1466 C CD1 . LEU C 3 16 ? -22.19855 -33.46294 7.76857   1.000 16.16000 ? 40  LEU A CD1 1 
ATOM   1467 C CD2 . LEU C 3 16 ? -22.59710 -33.72751 5.32365   1.000 17.50205 ? 40  LEU A CD2 1 
ATOM   1468 N N   . ARG C 3 17 ? -22.83568 -38.34911 7.85134   1.000 16.82211 ? 41  ARG A N   1 
ATOM   1469 C CA  . ARG C 3 17 ? -23.99080 -39.08434 8.36082   1.000 19.09069 ? 41  ARG A CA  1 
ATOM   1470 C C   . ARG C 3 17 ? -23.94049 -39.18435 9.88356   1.000 20.39023 ? 41  ARG A C   1 
ATOM   1471 O O   . ARG C 3 17 ? -24.95118 -38.96686 10.56357  1.000 17.75309 ? 41  ARG A O   1 
ATOM   1472 C CB  . ARG C 3 17 ? -24.05042 -40.48831 7.74062   1.000 21.94314 ? 41  ARG A CB  1 
ATOM   1473 C CG  . ARG C 3 17 ? -24.28387 -40.56176 6.19767   1.000 21.68252 ? 41  ARG A CG  1 
ATOM   1474 C CD  . ARG C 3 17 ? -24.00237 -41.99071 5.65710   1.000 22.05630 ? 41  ARG A CD  1 
ATOM   1475 N NE  . ARG C 3 17 ? -24.44438 -42.20371 4.27469   1.000 27.25355 ? 41  ARG A NE  1 
ATOM   1476 C CZ  . ARG C 3 17 ? -24.55129 -43.40059 3.69662   1.000 27.68445 ? 41  ARG A CZ  1 
ATOM   1477 N NH1 . ARG C 3 17 ? -24.26927 -44.51545 4.35356   1.000 27.43297 ? 41  ARG A NH1 1 
ATOM   1478 N NH2 . ARG C 3 17 ? -24.96472 -43.48233 2.43444   1.000 22.72969 ? 41  ARG A NH2 1 
ATOM   1479 N N   . ALA C 3 18 ? -22.76486 -39.49757 10.43391  1.000 18.81071 ? 42  ALA A N   1 
ATOM   1480 C CA  . ALA C 3 18 ? -22.63084 -39.67243 11.88157  1.000 22.33913 ? 42  ALA A CA  1 
ATOM   1481 C C   . ALA C 3 18 ? -22.67312 -38.33189 12.60814  1.000 21.41070 ? 42  ALA A C   1 
ATOM   1482 O O   . ALA C 3 18 ? -23.27502 -38.22032 13.68388  1.000 21.87765 ? 42  ALA A O   1 
ATOM   1483 C CB  . ALA C 3 18 ? -21.32981 -40.42338 12.19545  1.000 19.25719 ? 42  ALA A CB  1 
ATOM   1484 N N   . LEU C 3 19 ? -22.04791 -37.30031 12.02841  1.000 19.90243 ? 43  LEU A N   1 
ATOM   1485 C CA  . LEU C 3 19 ? -22.07117 -35.97263 12.63579  1.000 19.18958 ? 43  LEU A CA  1 
ATOM   1486 C C   . LEU C 3 19 ? -23.48208 -35.41912 12.71664  1.000 19.10335 ? 43  LEU A C   1 
ATOM   1487 O O   . LEU C 3 19 ? -23.84729 -34.78636 13.71543  1.000 18.14153 ? 43  LEU A O   1 
ATOM   1488 C CB  . LEU C 3 19 ? -21.17507 -35.01471 11.84620  1.000 16.61909 ? 43  LEU A CB  1 
ATOM   1489 C CG  . LEU C 3 19 ? -19.66860 -35.26269 11.96807  1.000 21.05536 ? 43  LEU A CG  1 
ATOM   1490 C CD1 . LEU C 3 19 ? -18.91018 -34.24883 11.13345  1.000 19.17683 ? 43  LEU A CD1 1 
ATOM   1491 C CD2 . LEU C 3 19 ? -19.23013 -35.19358 13.43558  1.000 20.76173 ? 43  LEU A CD2 1 
ATOM   1492 N N   . ALA C 3 20 ? -24.28190 -35.61285 11.66079  1.000 17.44909 ? 44  ALA A N   1 
ATOM   1493 C CA  . ALA C 3 20 ? -25.65575 -35.11841 11.68062  1.000 16.45618 ? 44  ALA A CA  1 
ATOM   1494 C C   . ALA C 3 20 ? -26.48968 -35.85845 12.71908  1.000 17.54455 ? 44  ALA A C   1 
ATOM   1495 O O   . ALA C 3 20 ? -27.32951 -35.25205 13.39694  1.000 17.94692 ? 44  ALA A O   1 
ATOM   1496 C CB  . ALA C 3 20 ? -26.28121 -35.24818 10.29216  1.000 15.78013 ? 44  ALA A CB  1 
ATOM   1497 N N   . PHE C 3 21 ? -26.26750 -37.16903 12.85706  1.000 18.34620 ? 45  PHE A N   1 
ATOM   1498 C CA  . PHE C 3 21 ? -26.91941 -37.94176 13.91156  1.000 20.70654 ? 45  PHE A CA  1 
ATOM   1499 C C   . PHE C 3 21 ? -26.53642 -37.41966 15.29736  1.000 18.46113 ? 45  PHE A C   1 
ATOM   1500 O O   . PHE C 3 21 ? -27.40372 -37.19904 16.15105  1.000 19.50497 ? 45  PHE A O   1 
ATOM   1501 C CB  . PHE C 3 21 ? -26.56300 -39.42723 13.76240  1.000 19.13643 ? 45  PHE A CB  1 
ATOM   1502 C CG  . PHE C 3 21 ? -27.02322 -40.28807 14.91705  1.000 21.83669 ? 45  PHE A CG  1 
ATOM   1503 C CD1 . PHE C 3 21 ? -28.30398 -40.83548 14.92701  1.000 20.89854 ? 45  PHE A CD1 1 
ATOM   1504 C CD2 . PHE C 3 21 ? -26.16835 -40.56832 15.98361  1.000 21.14325 ? 45  PHE A CD2 1 
ATOM   1505 C CE1 . PHE C 3 21 ? -28.74106 -41.62954 15.98829  1.000 20.52404 ? 45  PHE A CE1 1 
ATOM   1506 C CE2 . PHE C 3 21 ? -26.59863 -41.36858 17.06242  1.000 21.46214 ? 45  PHE A CE2 1 
ATOM   1507 C CZ  . PHE C 3 21 ? -27.88979 -41.89828 17.05696  1.000 20.06578 ? 45  PHE A CZ  1 
ATOM   1508 N N   . CYS C 3 22 ? -25.23872 -37.20580 15.53787  1.000 20.38422 ? 46  CYS A N   1 
ATOM   1509 C CA  . CYS C 3 22 ? -24.79826 -36.73197 16.85198  1.000 19.96694 ? 46  CYS A CA  1 
ATOM   1510 C C   . CYS C 3 22 ? -25.37105 -35.36664 17.18818  1.000 19.30859 ? 46  CYS A C   1 
ATOM   1511 O O   . CYS C 3 22 ? -25.60227 -35.06185 18.36621  1.000 19.78060 ? 46  CYS A O   1 
ATOM   1512 C CB  . CYS C 3 22 ? -23.27391 -36.67862 16.91698  1.000 19.19335 ? 46  CYS A CB  1 
ATOM   1513 S SG  . CYS C 3 22 ? -22.56849 -38.32036 16.84381  1.000 27.52306 ? 46  CYS A SG  1 
ATOM   1514 N N   . ALA C 3 23 ? -25.59797 -34.53044 16.17761  1.000 18.77836 ? 47  ALA A N   1 
ATOM   1515 C CA  . ALA C 3 23 ? -26.13895 -33.20218 16.42683  1.000 19.09420 ? 47  ALA A CA  1 
ATOM   1516 C C   . ALA C 3 23 ? -27.52373 -33.25235 17.05287  1.000 21.67056 ? 47  ALA A C   1 
ATOM   1517 O O   . ALA C 3 23 ? -27.92190 -32.29284 17.71367  1.000 20.47304 ? 47  ALA A O   1 
ATOM   1518 C CB  . ALA C 3 23 ? -26.18481 -32.40184 15.12619  1.000 17.65337 ? 47  ALA A CB  1 
ATOM   1519 N N   . LEU C 3 24 ? -28.27032 -34.34125 16.86082  1.000 19.83023 ? 48  LEU A N   1 
ATOM   1520 C CA  . LEU C 3 24 ? -29.55418 -34.50907 17.52773  1.000 20.19809 ? 48  LEU A CA  1 
ATOM   1521 C C   . LEU C 3 24 ? -29.50429 -35.48667 18.69759  1.000 22.03830 ? 48  LEU A C   1 
ATOM   1522 O O   . LEU C 3 24 ? -30.32939 -35.37549 19.60957  1.000 21.69467 ? 48  LEU A O   1 
ATOM   1523 C CB  . LEU C 3 24 ? -30.61108 -34.98758 16.52470  1.000 20.04806 ? 48  LEU A CB  1 
ATOM   1524 C CG  . LEU C 3 24 ? -30.92229 -34.03545 15.36313  1.000 20.92818 ? 48  LEU A CG  1 
ATOM   1525 C CD1 . LEU C 3 24 ? -31.71188 -34.74498 14.26810  1.000 18.86950 ? 48  LEU A CD1 1 
ATOM   1526 C CD2 . LEU C 3 24 ? -31.69415 -32.82758 15.87349  1.000 23.21374 ? 48  LEU A CD2 1 
ATOM   1527 N N   . ALA C 3 25 ? -28.56393 -36.43462 18.69995  1.000 20.15198 ? 49  ALA A N   1 
ATOM   1528 C CA  . ALA C 3 25 ? -28.56817 -37.50462 19.69336  1.000 21.47785 ? 49  ALA A CA  1 
ATOM   1529 C C   . ALA C 3 25 ? -27.85354 -37.14357 20.99497  1.000 24.69614 ? 49  ALA A C   1 
ATOM   1530 O O   . ALA C 3 25 ? -28.14651 -37.74926 22.02874  1.000 23.79141 ? 49  ALA A O   1 
ATOM   1531 C CB  . ALA C 3 25 ? -27.91104 -38.76667 19.11826  1.000 18.03677 ? 49  ALA A CB  1 
ATOM   1532 N N   . LYS C 3 26 ? -26.91212 -36.20697 20.97593  1.000 22.00711 ? 50  LYS A N   1 
ATOM   1533 C CA  . LYS C 3 26 ? -26.06733 -35.99942 22.15048  1.000 29.76838 ? 50  LYS A CA  1 
ATOM   1534 C C   . LYS C 3 26 ? -26.46477 -34.77297 22.99538  1.000 33.66071 ? 50  LYS A C   1 
ATOM   1535 O O   . LYS C 3 26 ? -27.37173 -34.00816 22.63000  1.000 31.29810 ? 50  LYS A O   1 
ATOM   1536 C CB  . LYS C 3 26 ? -24.61027 -35.89080 21.71727  1.000 27.63273 ? 50  LYS A CB  1 
ATOM   1537 C CG  . LYS C 3 26 ? -23.98261 -37.23365 21.34147  1.000 29.19917 ? 50  LYS A CG  1 
ATOM   1538 C CD  . LYS C 3 26 ? -22.46588 -37.18765 21.54420  1.000 36.44888 ? 50  LYS A CD  1 
ATOM   1539 C CE  . LYS C 3 26 ? -21.78514 -38.31826 20.79916  1.000 40.17053 ? 50  LYS A CE  1 
ATOM   1540 N NZ  . LYS C 3 26 ? -22.48314 -39.60425 21.06938  1.000 40.67233 ? 50  LYS A NZ  1 
HETATM 1541 O O   . HOH D 4 .  ? -6.78260  -6.89637  -11.88093 1.000 29.26552 ? 201 HOH B O   1 
HETATM 1542 O O   . HOH D 4 .  ? 0.07239   -5.79548  -0.16226  1.000 36.73057 ? 202 HOH B O   1 
HETATM 1543 O O   . HOH D 4 .  ? -25.67312 -4.40144  -12.39066 1.000 36.24704 ? 203 HOH B O   1 
HETATM 1544 O O   . HOH D 4 .  ? -13.18089 -26.45632 -3.49525  1.000 20.14628 ? 204 HOH B O   1 
HETATM 1545 O O   . HOH D 4 .  ? -24.28244 -20.30707 -5.33405  1.000 18.09145 ? 205 HOH B O   1 
HETATM 1546 O O   . HOH D 4 .  ? -12.38531 -0.24571  1.90635   1.000 34.74731 ? 206 HOH B O   1 
HETATM 1547 O O   . HOH D 4 .  ? -19.51471 -3.43692  -8.97929  1.000 26.93849 ? 207 HOH B O   1 
HETATM 1548 O O   . HOH D 4 .  ? -22.68493 0.00000   0.00000   0.50  29.49050 ? 208 HOH B O   1 
HETATM 1549 O O   . HOH D 4 .  ? -37.38150 -23.03765 5.73963   1.000 48.83277 ? 209 HOH B O   1 
HETATM 1550 O O   . HOH D 4 .  ? 1.05823   -16.06008 -8.54842  1.000 28.17275 ? 210 HOH B O   1 
HETATM 1551 O O   . HOH D 4 .  ? -27.21950 -12.65174 -0.49806  1.000 36.35187 ? 211 HOH B O   1 
HETATM 1552 O O   . HOH D 4 .  ? -19.10860 -16.58123 4.75465   1.000 20.77372 ? 212 HOH B O   1 
HETATM 1553 O O   . HOH D 4 .  ? -9.42880  -15.09796 -19.49429 1.000 35.39659 ? 213 HOH B O   1 
HETATM 1554 O O   . HOH D 4 .  ? -20.49110 -23.41466 8.79183   1.000 28.56083 ? 214 HOH B O   1 
HETATM 1555 O O   . HOH D 4 .  ? 0.32525   -17.38205 4.62784   1.000 36.47046 ? 215 HOH B O   1 
HETATM 1556 O O   . HOH D 4 .  ? -11.21997 -5.77803  -6.77782  1.000 17.67226 ? 216 HOH B O   1 
HETATM 1557 O O   . HOH D 4 .  ? -25.16582 -8.42077  -14.29806 1.000 33.93189 ? 217 HOH B O   1 
HETATM 1558 O O   . HOH D 4 .  ? -3.28338  -17.36048 -8.73542  1.000 20.74386 ? 218 HOH B O   1 
HETATM 1559 O O   . HOH D 4 .  ? -19.07001 -19.48169 6.63407   1.000 27.16270 ? 219 HOH B O   1 
HETATM 1560 O O   . HOH D 4 .  ? -0.73198  -8.63672  -6.39315  1.000 27.44185 ? 220 HOH B O   1 
HETATM 1561 O O   . HOH D 4 .  ? -4.87924  -15.37083 -3.65319  1.000 27.27606 ? 221 HOH B O   1 
HETATM 1562 O O   . HOH D 4 .  ? -22.34280 -16.18326 1.82282   1.000 21.03857 ? 222 HOH B O   1 
HETATM 1563 O O   . HOH D 4 .  ? -8.35450  -21.57318 -11.28912 1.000 23.34062 ? 223 HOH B O   1 
HETATM 1564 O O   . HOH D 4 .  ? -6.96348  -3.16393  -7.63595  1.000 34.28351 ? 224 HOH B O   1 
HETATM 1565 O O   . HOH D 4 .  ? -23.95842 -17.03838 -5.16728  1.000 20.09003 ? 225 HOH B O   1 
HETATM 1566 O O   . HOH D 4 .  ? -18.25040 -10.60017 1.51220   1.000 22.08302 ? 226 HOH B O   1 
HETATM 1567 O O   . HOH D 4 .  ? -19.43815 -9.22844  -0.78449  1.000 22.95591 ? 227 HOH B O   1 
HETATM 1568 O O   . HOH D 4 .  ? -14.75365 -18.71153 10.08454  1.000 34.54367 ? 228 HOH B O   1 
HETATM 1569 O O   . HOH D 4 .  ? -19.951   -1.403    -2.939    1.000 30.03901 ? 229 HOH B O   1 
HETATM 1570 O O   . HOH D 4 .  ? -16.11962 -5.93914  -20.49719 1.000 41.83212 ? 230 HOH B O   1 
HETATM 1571 O O   . HOH D 4 .  ? -25.06780 -7.99096  -11.12875 1.000 29.36500 ? 231 HOH B O   1 
HETATM 1572 O O   . HOH D 4 .  ? 2.924     -11.768   -0.313    1.000 29.79569 ? 232 HOH B O   1 
HETATM 1573 O O   . HOH D 4 .  ? -15.19206 -24.50683 2.70618   1.000 17.62705 ? 233 HOH B O   1 
HETATM 1574 O O   . HOH D 4 .  ? -20.50714 -9.09545  -17.66944 1.000 31.54746 ? 234 HOH B O   1 
HETATM 1575 O O   . HOH D 4 .  ? -21.03549 -16.33212 -12.18508 1.000 26.89622 ? 235 HOH B O   1 
HETATM 1576 O O   . HOH D 4 .  ? -8.79954  -2.68685  -0.74777  1.000 35.03295 ? 236 HOH B O   1 
HETATM 1577 O O   . HOH D 4 .  ? -22.27917 -9.50804  -8.69026  1.000 22.70394 ? 237 HOH B O   1 
HETATM 1578 O O   . HOH D 4 .  ? -24.89626 -17.45498 -11.35872 1.000 26.62500 ? 238 HOH B O   1 
HETATM 1579 O O   . HOH D 4 .  ? -6.26420  -8.74351  -16.49393 1.000 32.82461 ? 239 HOH B O   1 
HETATM 1580 O O   . HOH D 4 .  ? 1.81333   -16.46509 -0.85434  1.000 31.99077 ? 240 HOH B O   1 
HETATM 1581 O O   . HOH D 4 .  ? -13.38537 -23.08537 0.93087   1.000 22.16008 ? 241 HOH B O   1 
HETATM 1582 O O   . HOH D 4 .  ? -19.21294 -13.97406 -17.67035 1.000 33.07781 ? 242 HOH B O   1 
HETATM 1583 O O   . HOH D 4 .  ? -26.17120 -8.80068  -2.85977  1.000 28.97943 ? 243 HOH B O   1 
HETATM 1584 O O   . HOH D 4 .  ? -24.98401 -13.26545 -15.91497 1.000 37.57138 ? 244 HOH B O   1 
HETATM 1585 O O   . HOH D 4 .  ? -22.15348 -2.86059  -5.91526  1.000 33.69492 ? 245 HOH B O   1 
HETATM 1586 O O   . HOH D 4 .  ? -27.45765 -16.93663 2.25547   1.000 31.85995 ? 246 HOH B O   1 
HETATM 1587 O O   . HOH D 4 .  ? -14.85918 -4.86756  4.44194   1.000 30.52358 ? 247 HOH B O   1 
HETATM 1588 O O   . HOH D 4 .  ? -2.30224  -19.08229 -2.67241  1.000 34.61570 ? 248 HOH B O   1 
HETATM 1589 O O   . HOH D 4 .  ? -3.22626  -2.24819  -6.04479  1.000 38.70684 ? 249 HOH B O   1 
HETATM 1590 O O   . HOH D 4 .  ? -8.69918  -22.73757 9.97007   1.000 38.43877 ? 250 HOH B O   1 
HETATM 1591 O O   . HOH D 4 .  ? -20.24530 -10.96987 3.03147   1.000 28.61094 ? 251 HOH B O   1 
HETATM 1592 O O   . HOH D 4 .  ? -11.27598 -5.00392  3.30580   1.000 38.97197 ? 252 HOH B O   1 
HETATM 1593 O O   . HOH D 4 .  ? -6.66974  -23.29267 -5.02589  1.000 37.51312 ? 253 HOH B O   1 
HETATM 1594 O O   . HOH D 4 .  ? -10.38921 -3.80050  -8.25254  1.000 41.37731 ? 254 HOH B O   1 
HETATM 1595 O O   . HOH D 4 .  ? -11.98575 -24.84913 -0.45012  1.000 21.55934 ? 255 HOH B O   1 
HETATM 1596 O O   . HOH D 4 .  ? 0.26213   -18.19323 -3.04930  1.000 40.91988 ? 256 HOH B O   1 
HETATM 1597 O O   . HOH D 4 .  ? -21.86782 -8.82313  0.05926   1.000 23.96740 ? 257 HOH B O   1 
HETATM 1598 O O   . HOH D 4 .  ? -3.75388  -17.79341 -4.69708  1.000 35.63315 ? 258 HOH B O   1 
HETATM 1599 O O   . HOH D 4 .  ? -20.84642 -19.79016 -14.29270 1.000 37.74827 ? 259 HOH B O   1 
HETATM 1600 O O   . HOH D 4 .  ? -10.16427 -3.48780  1.86124   1.000 37.24927 ? 260 HOH B O   1 
HETATM 1601 O O   . HOH D 4 .  ? -0.84650  -6.91234  -8.37284  1.000 29.84863 ? 261 HOH B O   1 
HETATM 1602 O O   . HOH D 4 .  ? -20.33010 -17.32688 -14.63954 1.000 31.98647 ? 262 HOH B O   1 
HETATM 1603 O O   . HOH D 4 .  ? -21.31296 -18.45886 5.50889   1.000 37.83580 ? 263 HOH B O   1 
HETATM 1604 O O   . HOH D 4 .  ? -2.26385  -18.48369 -6.63841  1.000 32.46209 ? 264 HOH B O   1 
HETATM 1605 O O   . HOH D 4 .  ? -22.177   2.959     3.454     1.000 34.35416 ? 265 HOH B O   1 
HETATM 1606 O O   . HOH E 4 .  ? -21.94736 -20.96434 -12.02894 1.000 26.77809 ? 201 HOH C O   1 
HETATM 1607 O O   . HOH E 4 .  ? -14.36534 -34.50805 -13.08583 1.000 46.22128 ? 202 HOH C O   1 
HETATM 1608 O O   . HOH E 4 .  ? -20.46585 -31.83850 14.23348  1.000 27.21085 ? 203 HOH C O   1 
HETATM 1609 O O   . HOH E 4 .  ? -17.06538 -38.74031 4.78573   1.000 26.38781 ? 204 HOH C O   1 
HETATM 1610 O O   . HOH E 4 .  ? -4.99487  -33.35382 8.15852   1.000 36.54039 ? 205 HOH C O   1 
HETATM 1611 O O   . HOH E 4 .  ? -22.18175 -33.57511 -16.21797 1.000 31.53331 ? 206 HOH C O   1 
HETATM 1612 O O   . HOH E 4 .  ? -33.04706 -19.94752 -3.61600  1.000 33.03086 ? 207 HOH C O   1 
HETATM 1613 O O   . HOH E 4 .  ? -15.57984 -25.00961 14.24276  1.000 27.90705 ? 208 HOH C O   1 
HETATM 1614 O O   . HOH E 4 .  ? -27.08753 -42.81587 7.91832   1.000 23.82020 ? 209 HOH C O   1 
HETATM 1615 O O   . HOH E 4 .  ? -13.28425 -27.11005 -0.89506  1.000 24.42036 ? 210 HOH C O   1 
HETATM 1616 O O   . HOH E 4 .  ? -30.50041 -29.24006 -9.91086  1.000 28.30874 ? 211 HOH C O   1 
HETATM 1617 O O   . HOH E 4 .  ? -37.392   -34.356   -8.948    1.000 38.51656 ? 212 HOH C O   1 
HETATM 1618 O O   . HOH E 4 .  ? -35.65341 -25.84535 -3.95619  1.000 32.98717 ? 213 HOH C O   1 
HETATM 1619 O O   . HOH E 4 .  ? -24.12486 -43.92077 -3.12127  1.000 20.81778 ? 214 HOH C O   1 
HETATM 1620 O O   . HOH E 4 .  ? -33.819   -36.598   -7.776    1.000 24.89901 ? 215 HOH C O   1 
HETATM 1621 O O   . HOH E 4 .  ? -21.67903 -44.59354 -2.60900  1.000 28.92843 ? 216 HOH C O   1 
HETATM 1622 O O   . HOH E 4 .  ? -28.704   -36.286   -10.413   1.000 28.40573 ? 217 HOH C O   1 
HETATM 1623 O O   . HOH E 4 .  ? -11.06925 -37.47163 -2.49516  1.000 36.27737 ? 218 HOH C O   1 
HETATM 1624 O O   . HOH E 4 .  ? -33.37420 -31.26395 12.02408  1.000 21.37565 ? 219 HOH C O   1 
HETATM 1625 O O   . HOH E 4 .  ? -18.00588 -32.01806 15.25020  1.000 34.71113 ? 220 HOH C O   1 
HETATM 1626 O O   . HOH E 4 .  ? -9.35979  -31.41902 -7.66576  1.000 28.68869 ? 221 HOH C O   1 
HETATM 1627 O O   . HOH E 4 .  ? -25.55800 -25.38853 10.82270  1.000 24.91698 ? 222 HOH C O   1 
HETATM 1628 O O   . HOH E 4 .  ? -10.55271 -24.43956 11.51327  1.000 36.42314 ? 223 HOH C O   1 
HETATM 1629 O O   . HOH E 4 .  ? -13.00561 -33.64256 -17.63901 1.000 42.64110 ? 224 HOH C O   1 
HETATM 1630 O O   . HOH E 4 .  ? -30.89382 -34.62377 -5.19488  1.000 20.68629 ? 225 HOH C O   1 
HETATM 1631 O O   . HOH E 4 .  ? -33.60811 -30.54999 9.38655   1.000 21.99929 ? 226 HOH C O   1 
HETATM 1632 O O   . HOH E 4 .  ? -22.57235 -28.67384 16.16306  1.000 34.80863 ? 227 HOH C O   1 
HETATM 1633 O O   . HOH E 4 .  ? -31.51431 -32.68583 1.97914   1.000 32.34174 ? 228 HOH C O   1 
HETATM 1634 O O   . HOH E 4 .  ? -25.48125 -43.67182 -0.97936  1.000 27.82688 ? 229 HOH C O   1 
HETATM 1635 O O   . HOH E 4 .  ? -31.16433 -35.94465 -7.18750  1.000 27.15474 ? 230 HOH C O   1 
HETATM 1636 O O   . HOH E 4 .  ? -35.29524 -32.29558 13.74076  1.000 25.30850 ? 231 HOH C O   1 
HETATM 1637 O O   . HOH E 4 .  ? -35.96030 -24.46972 -2.06362  1.000 37.21694 ? 232 HOH C O   1 
HETATM 1638 O O   . HOH F 4 .  ? -29.81227 -33.90429 22.15803  1.000 28.39846 ? 101 HOH A O   1 
HETATM 1639 O O   . HOH F 4 .  ? -22.46143 -33.12377 15.37972  1.000 26.74880 ? 102 HOH A O   1 
HETATM 1640 O O   . HOH F 4 .  ? -24.59347 -46.12262 1.73392   1.000 39.20872 ? 103 HOH A O   1 
HETATM 1641 O O   . HOH F 4 .  ? -32.404   -33.569   19.326    1.000 29.74691 ? 104 HOH A O   1 
HETATM 1642 O O   . HOH F 4 .  ? -17.69303 -41.91143 10.59429  1.000 28.58638 ? 105 HOH A O   1 
HETATM 1643 O O   . HOH F 4 .  ? -15.36839 -35.77953 14.01492  1.000 32.11292 ? 106 HOH A O   1 
HETATM 1644 O O   . HOH F 4 .  ? -22.63941 -44.85730 7.19267   1.000 35.26012 ? 107 HOH A O   1 
# 
