data_9L8G
# 
_entry.id   9L8G 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9L8G         pdb_00009l8g 10.2210/pdb9l8g/pdb 
WWPDB D_1300055177 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-01-29 ? 
2 'Structure model' 1 1 2025-02-19 ? 
3 'Structure model' 1 2 2025-03-12 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Database references' 
2 3 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 3 'Structure model' citation        
4 3 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.pdbx_database_id_DOI'    
2 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
3 2 'Structure model' '_citation.title'                   
4 2 'Structure model' '_citation_author.identifier_ORCID' 
5 3 'Structure model' '_citation.journal_volume'          
6 3 'Structure model' '_citation.page_first'              
7 3 'Structure model' '_citation.page_last'               
8 3 'Structure model' '_citation_author.identifier_ORCID' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9L8G 
_pdbx_database_status.recvd_initial_deposition_date   2024-12-27 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              gkurisu@protein.osaka-u.ac.jp 
_pdbx_contact_author.name_first         Genji 
_pdbx_contact_author.name_last          Kurisu 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-5354-0807 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Uenaka, M.'  1 0009-0000-4663-7582 
'Ohnishi, Y.' 2 0000-0002-1378-054X 
'Tanaka, H.'  3 0000-0003-2035-954X 
'Kurisu, G.'  4 0000-0002-5354-0807 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acta Crystallogr.,Sect.F' 
_citation.journal_id_ASTM           ACSFEN 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2053-230X 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            81 
_citation.language                  ? 
_citation.page_first                73 
_citation.page_last                 84 
_citation.title                     
;Redox-dependent hydrogen-bond network rearrangement of ferredoxin-NADP + reductase revealed by high-resolution X-ray and neutron crystallography.
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1107/S2053230X25000524 
_citation.pdbx_database_id_PubMed   39913263 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Uenaka, M.'  1 ? 
primary 'Ohnishi, Y.' 2 ? 
primary 'Ise, A.'     3 ? 
primary 'Yu, J.'      4 ? 
primary 'Yano, N.'    5 ? 
primary 'Kusaka, K.'  6 ? 
primary 'Tanaka, H.'  7 ? 
primary 'Kurisu, G.'  8 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Ferredoxin--NADP reductase, chloroplastic' 34518.074 1   1.18.1.2 R115A 'UNP residues 17-327' ? 
2 non-polymer syn 'FLAVIN-ADENINE DINUCLEOTIDE'               785.550   1   ?        ?     ?                     ? 
3 non-polymer syn '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'      195.237   2   ?        ?     ?                     ? 
4 water       nat water                                       18.015    437 ?        ?     ?                     ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        FNR 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SKVSVAPLHLESAKEPPLNTYKPKEPFTATIVSVESLVGPKAPGETCHIVIDHGGNVPYWEGQSYGVIPPGENPKKPGAP
QNVRLYSIASTRYGDNFDGRTGSLCVARAVYYDPETGKEDPSKNGVCSNFLCNSKPGDKIQLTGPSGKIMLLPEEDPNAT
HIMIATGTGVAPFRGYLRRMFMEDVPNYRFGGLAWLFLGVANSDSLLYDEEFTSYLKQYPDNFRYDKALSREQKNRSGGK
MYVQDKIEEYSDEIFKLLDGGAHIYFCGLKGMMPGIQDTLKKVAERRGESWDQKLAQLKKNKQWHVEVY
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SKVSVAPLHLESAKEPPLNTYKPKEPFTATIVSVESLVGPKAPGETCHIVIDHGGNVPYWEGQSYGVIPPGENPKKPGAP
QNVRLYSIASTRYGDNFDGRTGSLCVARAVYYDPETGKEDPSKNGVCSNFLCNSKPGDKIQLTGPSGKIMLLPEEDPNAT
HIMIATGTGVAPFRGYLRRMFMEDVPNYRFGGLAWLFLGVANSDSLLYDEEFTSYLKQYPDNFRYDKALSREQKNRSGGK
MYVQDKIEEYSDEIFKLLDGGAHIYFCGLKGMMPGIQDTLKKVAERRGESWDQKLAQLKKNKQWHVEVY
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'FLAVIN-ADENINE DINUCLEOTIDE'          FAD 
3 '2-(N-MORPHOLINO)-ETHANESULFONIC ACID' MES 
4 water                                  HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   LYS n 
1 3   VAL n 
1 4   SER n 
1 5   VAL n 
1 6   ALA n 
1 7   PRO n 
1 8   LEU n 
1 9   HIS n 
1 10  LEU n 
1 11  GLU n 
1 12  SER n 
1 13  ALA n 
1 14  LYS n 
1 15  GLU n 
1 16  PRO n 
1 17  PRO n 
1 18  LEU n 
1 19  ASN n 
1 20  THR n 
1 21  TYR n 
1 22  LYS n 
1 23  PRO n 
1 24  LYS n 
1 25  GLU n 
1 26  PRO n 
1 27  PHE n 
1 28  THR n 
1 29  ALA n 
1 30  THR n 
1 31  ILE n 
1 32  VAL n 
1 33  SER n 
1 34  VAL n 
1 35  GLU n 
1 36  SER n 
1 37  LEU n 
1 38  VAL n 
1 39  GLY n 
1 40  PRO n 
1 41  LYS n 
1 42  ALA n 
1 43  PRO n 
1 44  GLY n 
1 45  GLU n 
1 46  THR n 
1 47  CYS n 
1 48  HIS n 
1 49  ILE n 
1 50  VAL n 
1 51  ILE n 
1 52  ASP n 
1 53  HIS n 
1 54  GLY n 
1 55  GLY n 
1 56  ASN n 
1 57  VAL n 
1 58  PRO n 
1 59  TYR n 
1 60  TRP n 
1 61  GLU n 
1 62  GLY n 
1 63  GLN n 
1 64  SER n 
1 65  TYR n 
1 66  GLY n 
1 67  VAL n 
1 68  ILE n 
1 69  PRO n 
1 70  PRO n 
1 71  GLY n 
1 72  GLU n 
1 73  ASN n 
1 74  PRO n 
1 75  LYS n 
1 76  LYS n 
1 77  PRO n 
1 78  GLY n 
1 79  ALA n 
1 80  PRO n 
1 81  GLN n 
1 82  ASN n 
1 83  VAL n 
1 84  ARG n 
1 85  LEU n 
1 86  TYR n 
1 87  SER n 
1 88  ILE n 
1 89  ALA n 
1 90  SER n 
1 91  THR n 
1 92  ARG n 
1 93  TYR n 
1 94  GLY n 
1 95  ASP n 
1 96  ASN n 
1 97  PHE n 
1 98  ASP n 
1 99  GLY n 
1 100 ARG n 
1 101 THR n 
1 102 GLY n 
1 103 SER n 
1 104 LEU n 
1 105 CYS n 
1 106 VAL n 
1 107 ALA n 
1 108 ARG n 
1 109 ALA n 
1 110 VAL n 
1 111 TYR n 
1 112 TYR n 
1 113 ASP n 
1 114 PRO n 
1 115 GLU n 
1 116 THR n 
1 117 GLY n 
1 118 LYS n 
1 119 GLU n 
1 120 ASP n 
1 121 PRO n 
1 122 SER n 
1 123 LYS n 
1 124 ASN n 
1 125 GLY n 
1 126 VAL n 
1 127 CYS n 
1 128 SER n 
1 129 ASN n 
1 130 PHE n 
1 131 LEU n 
1 132 CYS n 
1 133 ASN n 
1 134 SER n 
1 135 LYS n 
1 136 PRO n 
1 137 GLY n 
1 138 ASP n 
1 139 LYS n 
1 140 ILE n 
1 141 GLN n 
1 142 LEU n 
1 143 THR n 
1 144 GLY n 
1 145 PRO n 
1 146 SER n 
1 147 GLY n 
1 148 LYS n 
1 149 ILE n 
1 150 MET n 
1 151 LEU n 
1 152 LEU n 
1 153 PRO n 
1 154 GLU n 
1 155 GLU n 
1 156 ASP n 
1 157 PRO n 
1 158 ASN n 
1 159 ALA n 
1 160 THR n 
1 161 HIS n 
1 162 ILE n 
1 163 MET n 
1 164 ILE n 
1 165 ALA n 
1 166 THR n 
1 167 GLY n 
1 168 THR n 
1 169 GLY n 
1 170 VAL n 
1 171 ALA n 
1 172 PRO n 
1 173 PHE n 
1 174 ARG n 
1 175 GLY n 
1 176 TYR n 
1 177 LEU n 
1 178 ARG n 
1 179 ARG n 
1 180 MET n 
1 181 PHE n 
1 182 MET n 
1 183 GLU n 
1 184 ASP n 
1 185 VAL n 
1 186 PRO n 
1 187 ASN n 
1 188 TYR n 
1 189 ARG n 
1 190 PHE n 
1 191 GLY n 
1 192 GLY n 
1 193 LEU n 
1 194 ALA n 
1 195 TRP n 
1 196 LEU n 
1 197 PHE n 
1 198 LEU n 
1 199 GLY n 
1 200 VAL n 
1 201 ALA n 
1 202 ASN n 
1 203 SER n 
1 204 ASP n 
1 205 SER n 
1 206 LEU n 
1 207 LEU n 
1 208 TYR n 
1 209 ASP n 
1 210 GLU n 
1 211 GLU n 
1 212 PHE n 
1 213 THR n 
1 214 SER n 
1 215 TYR n 
1 216 LEU n 
1 217 LYS n 
1 218 GLN n 
1 219 TYR n 
1 220 PRO n 
1 221 ASP n 
1 222 ASN n 
1 223 PHE n 
1 224 ARG n 
1 225 TYR n 
1 226 ASP n 
1 227 LYS n 
1 228 ALA n 
1 229 LEU n 
1 230 SER n 
1 231 ARG n 
1 232 GLU n 
1 233 GLN n 
1 234 LYS n 
1 235 ASN n 
1 236 ARG n 
1 237 SER n 
1 238 GLY n 
1 239 GLY n 
1 240 LYS n 
1 241 MET n 
1 242 TYR n 
1 243 VAL n 
1 244 GLN n 
1 245 ASP n 
1 246 LYS n 
1 247 ILE n 
1 248 GLU n 
1 249 GLU n 
1 250 TYR n 
1 251 SER n 
1 252 ASP n 
1 253 GLU n 
1 254 ILE n 
1 255 PHE n 
1 256 LYS n 
1 257 LEU n 
1 258 LEU n 
1 259 ASP n 
1 260 GLY n 
1 261 GLY n 
1 262 ALA n 
1 263 HIS n 
1 264 ILE n 
1 265 TYR n 
1 266 PHE n 
1 267 CYS n 
1 268 GLY n 
1 269 LEU n 
1 270 LYS n 
1 271 GLY n 
1 272 MET n 
1 273 MET n 
1 274 PRO n 
1 275 GLY n 
1 276 ILE n 
1 277 GLN n 
1 278 ASP n 
1 279 THR n 
1 280 LEU n 
1 281 LYS n 
1 282 LYS n 
1 283 VAL n 
1 284 ALA n 
1 285 GLU n 
1 286 ARG n 
1 287 ARG n 
1 288 GLY n 
1 289 GLU n 
1 290 SER n 
1 291 TRP n 
1 292 ASP n 
1 293 GLN n 
1 294 LYS n 
1 295 LEU n 
1 296 ALA n 
1 297 GLN n 
1 298 LEU n 
1 299 LYS n 
1 300 LYS n 
1 301 ASN n 
1 302 LYS n 
1 303 GLN n 
1 304 TRP n 
1 305 HIS n 
1 306 VAL n 
1 307 GLU n 
1 308 VAL n 
1 309 TYR n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   309 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 '542713, ZEAMMB73_Zm00001d034345' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Zea mays' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     4577 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                ? 'C3 H7 N O2'        89.093  
ARG 'L-peptide linking' y ARGININE                               ? 'C6 H15 N4 O2 1'    175.209 
ASN 'L-peptide linking' y ASPARAGINE                             ? 'C4 H8 N2 O3'       132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                        ? 'C4 H7 N O4'        133.103 
CYS 'L-peptide linking' y CYSTEINE                               ? 'C3 H7 N O2 S'      121.158 
FAD non-polymer         . 'FLAVIN-ADENINE DINUCLEOTIDE'          ? 'C27 H33 N9 O15 P2' 785.550 
GLN 'L-peptide linking' y GLUTAMINE                              ? 'C5 H10 N2 O3'      146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                        ? 'C5 H9 N O4'        147.129 
GLY 'peptide linking'   y GLYCINE                                ? 'C2 H5 N O2'        75.067  
HIS 'L-peptide linking' y HISTIDINE                              ? 'C6 H10 N3 O2 1'    156.162 
HOH non-polymer         . WATER                                  ? 'H2 O'              18.015  
ILE 'L-peptide linking' y ISOLEUCINE                             ? 'C6 H13 N O2'       131.173 
LEU 'L-peptide linking' y LEUCINE                                ? 'C6 H13 N O2'       131.173 
LYS 'L-peptide linking' y LYSINE                                 ? 'C6 H15 N2 O2 1'    147.195 
MES non-polymer         . '2-(N-MORPHOLINO)-ETHANESULFONIC ACID' ? 'C6 H13 N O4 S'     195.237 
MET 'L-peptide linking' y METHIONINE                             ? 'C5 H11 N O2 S'     149.211 
PHE 'L-peptide linking' y PHENYLALANINE                          ? 'C9 H11 N O2'       165.189 
PRO 'L-peptide linking' y PROLINE                                ? 'C5 H9 N O2'        115.130 
SER 'L-peptide linking' y SERINE                                 ? 'C3 H7 N O3'        105.093 
THR 'L-peptide linking' y THREONINE                              ? 'C4 H9 N O3'        119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                             ? 'C11 H12 N2 O2'     204.225 
TYR 'L-peptide linking' y TYROSINE                               ? 'C9 H11 N O3'       181.189 
VAL 'L-peptide linking' y VALINE                                 ? 'C5 H11 N O2'       117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1009 1009 SER SER A . n 
A 1 2   LYS 2   1010 1010 LYS LYS A . n 
A 1 3   VAL 3   1011 1011 VAL VAL A . n 
A 1 4   SER 4   1012 1012 SER SER A . n 
A 1 5   VAL 5   1013 1013 VAL VAL A . n 
A 1 6   ALA 6   1014 1014 ALA ALA A . n 
A 1 7   PRO 7   1015 1015 PRO PRO A . n 
A 1 8   LEU 8   1016 1016 LEU LEU A . n 
A 1 9   HIS 9   1017 1017 HIS HIS A . n 
A 1 10  LEU 10  1018 1018 LEU LEU A . n 
A 1 11  GLU 11  1019 1019 GLU GLU A . n 
A 1 12  SER 12  1020 1020 SER SER A . n 
A 1 13  ALA 13  1021 1021 ALA ALA A . n 
A 1 14  LYS 14  1022 1022 LYS LYS A . n 
A 1 15  GLU 15  1023 1023 GLU GLU A . n 
A 1 16  PRO 16  1024 1024 PRO PRO A . n 
A 1 17  PRO 17  1025 1025 PRO PRO A . n 
A 1 18  LEU 18  1026 1026 LEU LEU A . n 
A 1 19  ASN 19  1027 1027 ASN ASN A . n 
A 1 20  THR 20  1028 1028 THR THR A . n 
A 1 21  TYR 21  1029 1029 TYR TYR A . n 
A 1 22  LYS 22  1030 1030 LYS LYS A . n 
A 1 23  PRO 23  1031 1031 PRO PRO A . n 
A 1 24  LYS 24  1032 1032 LYS LYS A . n 
A 1 25  GLU 25  1033 1033 GLU GLU A . n 
A 1 26  PRO 26  1034 1034 PRO PRO A . n 
A 1 27  PHE 27  1035 1035 PHE PHE A . n 
A 1 28  THR 28  1036 1036 THR THR A . n 
A 1 29  ALA 29  1037 1037 ALA ALA A . n 
A 1 30  THR 30  1038 1038 THR THR A . n 
A 1 31  ILE 31  1039 1039 ILE ILE A . n 
A 1 32  VAL 32  1040 1040 VAL VAL A . n 
A 1 33  SER 33  1041 1041 SER SER A . n 
A 1 34  VAL 34  1042 1042 VAL VAL A . n 
A 1 35  GLU 35  1043 1043 GLU GLU A . n 
A 1 36  SER 36  1044 1044 SER SER A . n 
A 1 37  LEU 37  1045 1045 LEU LEU A . n 
A 1 38  VAL 38  1046 1046 VAL VAL A . n 
A 1 39  GLY 39  1047 1047 GLY GLY A . n 
A 1 40  PRO 40  1048 1048 PRO PRO A . n 
A 1 41  LYS 41  1049 1049 LYS LYS A . n 
A 1 42  ALA 42  1050 1050 ALA ALA A . n 
A 1 43  PRO 43  1051 1051 PRO PRO A . n 
A 1 44  GLY 44  1052 1052 GLY GLY A . n 
A 1 45  GLU 45  1053 1053 GLU GLU A . n 
A 1 46  THR 46  1054 1054 THR THR A . n 
A 1 47  CYS 47  1055 1055 CYS CYS A . n 
A 1 48  HIS 48  1056 1056 HIS HIS A . n 
A 1 49  ILE 49  1057 1057 ILE ILE A . n 
A 1 50  VAL 50  1058 1058 VAL VAL A . n 
A 1 51  ILE 51  1059 1059 ILE ILE A . n 
A 1 52  ASP 52  1060 1060 ASP ASP A . n 
A 1 53  HIS 53  1061 1061 HIS HIS A . n 
A 1 54  GLY 54  1062 1062 GLY GLY A . n 
A 1 55  GLY 55  1063 1063 GLY GLY A . n 
A 1 56  ASN 56  1064 1064 ASN ASN A . n 
A 1 57  VAL 57  1065 1065 VAL VAL A . n 
A 1 58  PRO 58  1066 1066 PRO PRO A . n 
A 1 59  TYR 59  1067 1067 TYR TYR A . n 
A 1 60  TRP 60  1068 1068 TRP TRP A . n 
A 1 61  GLU 61  1069 1069 GLU GLU A . n 
A 1 62  GLY 62  1070 1070 GLY GLY A . n 
A 1 63  GLN 63  1071 1071 GLN GLN A . n 
A 1 64  SER 64  1072 1072 SER SER A . n 
A 1 65  TYR 65  1073 1073 TYR TYR A . n 
A 1 66  GLY 66  1074 1074 GLY GLY A . n 
A 1 67  VAL 67  1075 1075 VAL VAL A . n 
A 1 68  ILE 68  1076 1076 ILE ILE A . n 
A 1 69  PRO 69  1077 1077 PRO PRO A . n 
A 1 70  PRO 70  1078 1078 PRO PRO A . n 
A 1 71  GLY 71  1079 1079 GLY GLY A . n 
A 1 72  GLU 72  1080 1080 GLU GLU A . n 
A 1 73  ASN 73  1081 1081 ASN ASN A . n 
A 1 74  PRO 74  1082 1082 PRO PRO A . n 
A 1 75  LYS 75  1083 1083 LYS LYS A . n 
A 1 76  LYS 76  1084 1084 LYS LYS A . n 
A 1 77  PRO 77  1085 1085 PRO PRO A . n 
A 1 78  GLY 78  1086 1086 GLY GLY A . n 
A 1 79  ALA 79  1087 1087 ALA ALA A . n 
A 1 80  PRO 80  1088 1088 PRO PRO A . n 
A 1 81  GLN 81  1089 1089 GLN GLN A . n 
A 1 82  ASN 82  1090 1090 ASN ASN A . n 
A 1 83  VAL 83  1091 1091 VAL VAL A . n 
A 1 84  ARG 84  1092 1092 ARG ARG A . n 
A 1 85  LEU 85  1093 1093 LEU LEU A . n 
A 1 86  TYR 86  1094 1094 TYR TYR A . n 
A 1 87  SER 87  1095 1095 SER SER A . n 
A 1 88  ILE 88  1096 1096 ILE ILE A . n 
A 1 89  ALA 89  1097 1097 ALA ALA A . n 
A 1 90  SER 90  1098 1098 SER SER A . n 
A 1 91  THR 91  1099 1099 THR THR A . n 
A 1 92  ARG 92  1100 1100 ARG ARG A . n 
A 1 93  TYR 93  1101 1101 TYR TYR A . n 
A 1 94  GLY 94  1102 1102 GLY GLY A . n 
A 1 95  ASP 95  1103 1103 ASP ASP A . n 
A 1 96  ASN 96  1104 1104 ASN ASN A . n 
A 1 97  PHE 97  1105 1105 PHE PHE A . n 
A 1 98  ASP 98  1106 1106 ASP ASP A . n 
A 1 99  GLY 99  1107 1107 GLY GLY A . n 
A 1 100 ARG 100 1108 1108 ARG ARG A . n 
A 1 101 THR 101 1109 1109 THR THR A . n 
A 1 102 GLY 102 1110 1110 GLY GLY A . n 
A 1 103 SER 103 1111 1111 SER SER A . n 
A 1 104 LEU 104 1112 1112 LEU LEU A . n 
A 1 105 CYS 105 1113 1113 CYS CYS A . n 
A 1 106 VAL 106 1114 1114 VAL VAL A . n 
A 1 107 ALA 107 1115 1115 ALA ALA A . n 
A 1 108 ARG 108 1116 1116 ARG ARG A . n 
A 1 109 ALA 109 1117 1117 ALA ALA A . n 
A 1 110 VAL 110 1118 1118 VAL VAL A . n 
A 1 111 TYR 111 1119 1119 TYR TYR A . n 
A 1 112 TYR 112 1120 1120 TYR TYR A . n 
A 1 113 ASP 113 1121 1121 ASP ASP A . n 
A 1 114 PRO 114 1122 1122 PRO PRO A . n 
A 1 115 GLU 115 1123 1123 GLU GLU A . n 
A 1 116 THR 116 1124 1124 THR THR A . n 
A 1 117 GLY 117 1125 1125 GLY GLY A . n 
A 1 118 LYS 118 1126 1126 LYS LYS A . n 
A 1 119 GLU 119 1127 1127 GLU GLU A . n 
A 1 120 ASP 120 1128 1128 ASP ASP A . n 
A 1 121 PRO 121 1129 1129 PRO PRO A . n 
A 1 122 SER 122 1130 1130 SER SER A . n 
A 1 123 LYS 123 1131 1131 LYS LYS A . n 
A 1 124 ASN 124 1132 1132 ASN ASN A . n 
A 1 125 GLY 125 1133 1133 GLY GLY A . n 
A 1 126 VAL 126 1134 1134 VAL VAL A . n 
A 1 127 CYS 127 1135 1135 CYS CYS A . n 
A 1 128 SER 128 1136 1136 SER SER A . n 
A 1 129 ASN 129 1137 1137 ASN ASN A . n 
A 1 130 PHE 130 1138 1138 PHE PHE A . n 
A 1 131 LEU 131 1139 1139 LEU LEU A . n 
A 1 132 CYS 132 1140 1140 CYS CYS A . n 
A 1 133 ASN 133 1141 1141 ASN ASN A . n 
A 1 134 SER 134 1142 1142 SER SER A . n 
A 1 135 LYS 135 1143 1143 LYS LYS A . n 
A 1 136 PRO 136 1144 1144 PRO PRO A . n 
A 1 137 GLY 137 1145 1145 GLY GLY A . n 
A 1 138 ASP 138 1146 1146 ASP ASP A . n 
A 1 139 LYS 139 1147 1147 LYS LYS A . n 
A 1 140 ILE 140 1148 1148 ILE ILE A . n 
A 1 141 GLN 141 1149 1149 GLN GLN A . n 
A 1 142 LEU 142 1150 1150 LEU LEU A . n 
A 1 143 THR 143 1151 1151 THR THR A . n 
A 1 144 GLY 144 1152 1152 GLY GLY A . n 
A 1 145 PRO 145 1153 1153 PRO PRO A . n 
A 1 146 SER 146 1154 1154 SER SER A . n 
A 1 147 GLY 147 1155 1155 GLY GLY A . n 
A 1 148 LYS 148 1156 1156 LYS LYS A . n 
A 1 149 ILE 149 1157 1157 ILE ILE A . n 
A 1 150 MET 150 1158 1158 MET MET A . n 
A 1 151 LEU 151 1159 1159 LEU LEU A . n 
A 1 152 LEU 152 1160 1160 LEU LEU A . n 
A 1 153 PRO 153 1161 1161 PRO PRO A . n 
A 1 154 GLU 154 1162 1162 GLU GLU A . n 
A 1 155 GLU 155 1163 1163 GLU GLU A . n 
A 1 156 ASP 156 1164 1164 ASP ASP A . n 
A 1 157 PRO 157 1165 1165 PRO PRO A . n 
A 1 158 ASN 158 1166 1166 ASN ASN A . n 
A 1 159 ALA 159 1167 1167 ALA ALA A . n 
A 1 160 THR 160 1168 1168 THR THR A . n 
A 1 161 HIS 161 1169 1169 HIS HIS A . n 
A 1 162 ILE 162 1170 1170 ILE ILE A . n 
A 1 163 MET 163 1171 1171 MET MET A . n 
A 1 164 ILE 164 1172 1172 ILE ILE A . n 
A 1 165 ALA 165 1173 1173 ALA ALA A . n 
A 1 166 THR 166 1174 1174 THR THR A . n 
A 1 167 GLY 167 1175 1175 GLY GLY A . n 
A 1 168 THR 168 1176 1176 THR THR A . n 
A 1 169 GLY 169 1177 1177 GLY GLY A . n 
A 1 170 VAL 170 1178 1178 VAL VAL A . n 
A 1 171 ALA 171 1179 1179 ALA ALA A . n 
A 1 172 PRO 172 1180 1180 PRO PRO A . n 
A 1 173 PHE 173 1181 1181 PHE PHE A . n 
A 1 174 ARG 174 1182 1182 ARG ARG A . n 
A 1 175 GLY 175 1183 1183 GLY GLY A . n 
A 1 176 TYR 176 1184 1184 TYR TYR A . n 
A 1 177 LEU 177 1185 1185 LEU LEU A . n 
A 1 178 ARG 178 1186 1186 ARG ARG A . n 
A 1 179 ARG 179 1187 1187 ARG ARG A . n 
A 1 180 MET 180 1188 1188 MET MET A . n 
A 1 181 PHE 181 1189 1189 PHE PHE A . n 
A 1 182 MET 182 1190 1190 MET MET A . n 
A 1 183 GLU 183 1191 1191 GLU GLU A . n 
A 1 184 ASP 184 1192 1192 ASP ASP A . n 
A 1 185 VAL 185 1193 1193 VAL VAL A . n 
A 1 186 PRO 186 1194 1194 PRO PRO A . n 
A 1 187 ASN 187 1195 1195 ASN ASN A . n 
A 1 188 TYR 188 1196 1196 TYR TYR A . n 
A 1 189 ARG 189 1197 1197 ARG ARG A . n 
A 1 190 PHE 190 1198 1198 PHE PHE A . n 
A 1 191 GLY 191 1199 1199 GLY GLY A . n 
A 1 192 GLY 192 1200 1200 GLY GLY A . n 
A 1 193 LEU 193 1201 1201 LEU LEU A . n 
A 1 194 ALA 194 1202 1202 ALA ALA A . n 
A 1 195 TRP 195 1203 1203 TRP TRP A . n 
A 1 196 LEU 196 1204 1204 LEU LEU A . n 
A 1 197 PHE 197 1205 1205 PHE PHE A . n 
A 1 198 LEU 198 1206 1206 LEU LEU A . n 
A 1 199 GLY 199 1207 1207 GLY GLY A . n 
A 1 200 VAL 200 1208 1208 VAL VAL A . n 
A 1 201 ALA 201 1209 1209 ALA ALA A . n 
A 1 202 ASN 202 1210 1210 ASN ASN A . n 
A 1 203 SER 203 1211 1211 SER SER A . n 
A 1 204 ASP 204 1212 1212 ASP ASP A . n 
A 1 205 SER 205 1213 1213 SER SER A . n 
A 1 206 LEU 206 1214 1214 LEU LEU A . n 
A 1 207 LEU 207 1215 1215 LEU LEU A . n 
A 1 208 TYR 208 1216 1216 TYR TYR A . n 
A 1 209 ASP 209 1217 1217 ASP ASP A . n 
A 1 210 GLU 210 1218 1218 GLU GLU A . n 
A 1 211 GLU 211 1219 1219 GLU GLU A . n 
A 1 212 PHE 212 1220 1220 PHE PHE A . n 
A 1 213 THR 213 1221 1221 THR THR A . n 
A 1 214 SER 214 1222 1222 SER SER A . n 
A 1 215 TYR 215 1223 1223 TYR TYR A . n 
A 1 216 LEU 216 1224 1224 LEU LEU A . n 
A 1 217 LYS 217 1225 1225 LYS LYS A . n 
A 1 218 GLN 218 1226 1226 GLN GLN A . n 
A 1 219 TYR 219 1227 1227 TYR TYR A . n 
A 1 220 PRO 220 1228 1228 PRO PRO A . n 
A 1 221 ASP 221 1229 1229 ASP ASP A . n 
A 1 222 ASN 222 1230 1230 ASN ASN A . n 
A 1 223 PHE 223 1231 1231 PHE PHE A . n 
A 1 224 ARG 224 1232 1232 ARG ARG A . n 
A 1 225 TYR 225 1233 1233 TYR TYR A . n 
A 1 226 ASP 226 1234 1234 ASP ASP A . n 
A 1 227 LYS 227 1235 1235 LYS LYS A . n 
A 1 228 ALA 228 1236 1236 ALA ALA A . n 
A 1 229 LEU 229 1237 1237 LEU LEU A . n 
A 1 230 SER 230 1238 1238 SER SER A . n 
A 1 231 ARG 231 1239 1239 ARG ARG A . n 
A 1 232 GLU 232 1240 1240 GLU GLU A . n 
A 1 233 GLN 233 1241 1241 GLN GLN A . n 
A 1 234 LYS 234 1242 1242 LYS LYS A . n 
A 1 235 ASN 235 1243 1243 ASN ASN A . n 
A 1 236 ARG 236 1244 1244 ARG ARG A . n 
A 1 237 SER 237 1245 1245 SER SER A . n 
A 1 238 GLY 238 1246 1246 GLY GLY A . n 
A 1 239 GLY 239 1247 1247 GLY GLY A . n 
A 1 240 LYS 240 1248 1248 LYS LYS A . n 
A 1 241 MET 241 1249 1249 MET MET A . n 
A 1 242 TYR 242 1250 1250 TYR TYR A . n 
A 1 243 VAL 243 1251 1251 VAL VAL A . n 
A 1 244 GLN 244 1252 1252 GLN GLN A . n 
A 1 245 ASP 245 1253 1253 ASP ASP A . n 
A 1 246 LYS 246 1254 1254 LYS LYS A . n 
A 1 247 ILE 247 1255 1255 ILE ILE A . n 
A 1 248 GLU 248 1256 1256 GLU GLU A . n 
A 1 249 GLU 249 1257 1257 GLU GLU A . n 
A 1 250 TYR 250 1258 1258 TYR TYR A . n 
A 1 251 SER 251 1259 1259 SER SER A . n 
A 1 252 ASP 252 1260 1260 ASP ASP A . n 
A 1 253 GLU 253 1261 1261 GLU GLU A . n 
A 1 254 ILE 254 1262 1262 ILE ILE A . n 
A 1 255 PHE 255 1263 1263 PHE PHE A . n 
A 1 256 LYS 256 1264 1264 LYS LYS A . n 
A 1 257 LEU 257 1265 1265 LEU LEU A . n 
A 1 258 LEU 258 1266 1266 LEU LEU A . n 
A 1 259 ASP 259 1267 1267 ASP ASP A . n 
A 1 260 GLY 260 1268 1268 GLY GLY A . n 
A 1 261 GLY 261 1269 1269 GLY GLY A . n 
A 1 262 ALA 262 1270 1270 ALA ALA A . n 
A 1 263 HIS 263 1271 1271 HIS HIS A . n 
A 1 264 ILE 264 1272 1272 ILE ILE A . n 
A 1 265 TYR 265 1273 1273 TYR TYR A . n 
A 1 266 PHE 266 1274 1274 PHE PHE A . n 
A 1 267 CYS 267 1275 1275 CYS CYS A . n 
A 1 268 GLY 268 1276 1276 GLY GLY A . n 
A 1 269 LEU 269 1277 1277 LEU LEU A . n 
A 1 270 LYS 270 1278 1278 LYS LYS A . n 
A 1 271 GLY 271 1279 1279 GLY GLY A . n 
A 1 272 MET 272 1280 1280 MET MET A . n 
A 1 273 MET 273 1281 1281 MET MET A . n 
A 1 274 PRO 274 1282 1282 PRO PRO A . n 
A 1 275 GLY 275 1283 1283 GLY GLY A . n 
A 1 276 ILE 276 1284 1284 ILE ILE A . n 
A 1 277 GLN 277 1285 1285 GLN GLN A . n 
A 1 278 ASP 278 1286 1286 ASP ASP A . n 
A 1 279 THR 279 1287 1287 THR THR A . n 
A 1 280 LEU 280 1288 1288 LEU LEU A . n 
A 1 281 LYS 281 1289 1289 LYS LYS A . n 
A 1 282 LYS 282 1290 1290 LYS LYS A . n 
A 1 283 VAL 283 1291 1291 VAL VAL A . n 
A 1 284 ALA 284 1292 1292 ALA ALA A . n 
A 1 285 GLU 285 1293 1293 GLU GLU A . n 
A 1 286 ARG 286 1294 1294 ARG ARG A . n 
A 1 287 ARG 287 1295 1295 ARG ARG A . n 
A 1 288 GLY 288 1296 1296 GLY GLY A . n 
A 1 289 GLU 289 1297 1297 GLU GLU A . n 
A 1 290 SER 290 1298 1298 SER SER A . n 
A 1 291 TRP 291 1299 1299 TRP TRP A . n 
A 1 292 ASP 292 1300 1300 ASP ASP A . n 
A 1 293 GLN 293 1301 1301 GLN GLN A . n 
A 1 294 LYS 294 1302 1302 LYS LYS A . n 
A 1 295 LEU 295 1303 1303 LEU LEU A . n 
A 1 296 ALA 296 1304 1304 ALA ALA A . n 
A 1 297 GLN 297 1305 1305 GLN GLN A . n 
A 1 298 LEU 298 1306 1306 LEU LEU A . n 
A 1 299 LYS 299 1307 1307 LYS LYS A . n 
A 1 300 LYS 300 1308 1308 LYS LYS A . n 
A 1 301 ASN 301 1309 1309 ASN ASN A . n 
A 1 302 LYS 302 1310 1310 LYS LYS A . n 
A 1 303 GLN 303 1311 1311 GLN GLN A . n 
A 1 304 TRP 304 1312 1312 TRP TRP A . n 
A 1 305 HIS 305 1313 1313 HIS HIS A . n 
A 1 306 VAL 306 1314 1314 VAL VAL A . n 
A 1 307 GLU 307 1315 1315 GLU GLU A . n 
A 1 308 VAL 308 1316 1316 VAL VAL A . n 
A 1 309 TYR 309 1317 1317 TYR TYR A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        FAD 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   FAD 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 FAD 1   1401 1401 FAD FAD A . 
C 3 MES 1   1402 1402 MES MES A . 
D 3 MES 1   1403 1403 MES MES A . 
E 4 HOH 1   1501 192  HOH HOH A . 
E 4 HOH 2   1502 325  HOH HOH A . 
E 4 HOH 3   1503 268  HOH HOH A . 
E 4 HOH 4   1504 176  HOH HOH A . 
E 4 HOH 5   1505 195  HOH HOH A . 
E 4 HOH 6   1506 159  HOH HOH A . 
E 4 HOH 7   1507 444  HOH HOH A . 
E 4 HOH 8   1508 163  HOH HOH A . 
E 4 HOH 9   1509 349  HOH HOH A . 
E 4 HOH 10  1510 133  HOH HOH A . 
E 4 HOH 11  1511 303  HOH HOH A . 
E 4 HOH 12  1512 347  HOH HOH A . 
E 4 HOH 13  1513 284  HOH HOH A . 
E 4 HOH 14  1514 171  HOH HOH A . 
E 4 HOH 15  1515 200  HOH HOH A . 
E 4 HOH 16  1516 155  HOH HOH A . 
E 4 HOH 17  1517 456  HOH HOH A . 
E 4 HOH 18  1518 93   HOH HOH A . 
E 4 HOH 19  1519 103  HOH HOH A . 
E 4 HOH 20  1520 392  HOH HOH A . 
E 4 HOH 21  1521 401  HOH HOH A . 
E 4 HOH 22  1522 186  HOH HOH A . 
E 4 HOH 23  1523 53   HOH HOH A . 
E 4 HOH 24  1524 59   HOH HOH A . 
E 4 HOH 25  1525 144  HOH HOH A . 
E 4 HOH 26  1526 390  HOH HOH A . 
E 4 HOH 27  1527 102  HOH HOH A . 
E 4 HOH 28  1528 21   HOH HOH A . 
E 4 HOH 29  1529 275  HOH HOH A . 
E 4 HOH 30  1530 301  HOH HOH A . 
E 4 HOH 31  1531 94   HOH HOH A . 
E 4 HOH 32  1532 29   HOH HOH A . 
E 4 HOH 33  1533 357  HOH HOH A . 
E 4 HOH 34  1534 184  HOH HOH A . 
E 4 HOH 35  1535 232  HOH HOH A . 
E 4 HOH 36  1536 72   HOH HOH A . 
E 4 HOH 37  1537 132  HOH HOH A . 
E 4 HOH 38  1538 75   HOH HOH A . 
E 4 HOH 39  1539 71   HOH HOH A . 
E 4 HOH 40  1540 2    HOH HOH A . 
E 4 HOH 41  1541 99   HOH HOH A . 
E 4 HOH 42  1542 474  HOH HOH A . 
E 4 HOH 43  1543 468  HOH HOH A . 
E 4 HOH 44  1544 58   HOH HOH A . 
E 4 HOH 45  1545 36   HOH HOH A . 
E 4 HOH 46  1546 334  HOH HOH A . 
E 4 HOH 47  1547 14   HOH HOH A . 
E 4 HOH 48  1548 54   HOH HOH A . 
E 4 HOH 49  1549 98   HOH HOH A . 
E 4 HOH 50  1550 258  HOH HOH A . 
E 4 HOH 51  1551 8    HOH HOH A . 
E 4 HOH 52  1552 97   HOH HOH A . 
E 4 HOH 53  1553 380  HOH HOH A . 
E 4 HOH 54  1554 395  HOH HOH A . 
E 4 HOH 55  1555 31   HOH HOH A . 
E 4 HOH 56  1556 34   HOH HOH A . 
E 4 HOH 57  1557 286  HOH HOH A . 
E 4 HOH 58  1558 158  HOH HOH A . 
E 4 HOH 59  1559 108  HOH HOH A . 
E 4 HOH 60  1560 91   HOH HOH A . 
E 4 HOH 61  1561 1    HOH HOH A . 
E 4 HOH 62  1562 151  HOH HOH A . 
E 4 HOH 63  1563 419  HOH HOH A . 
E 4 HOH 64  1564 26   HOH HOH A . 
E 4 HOH 65  1565 197  HOH HOH A . 
E 4 HOH 66  1566 169  HOH HOH A . 
E 4 HOH 67  1567 341  HOH HOH A . 
E 4 HOH 68  1568 42   HOH HOH A . 
E 4 HOH 69  1569 310  HOH HOH A . 
E 4 HOH 70  1570 12   HOH HOH A . 
E 4 HOH 71  1571 45   HOH HOH A . 
E 4 HOH 72  1572 25   HOH HOH A . 
E 4 HOH 73  1573 174  HOH HOH A . 
E 4 HOH 74  1574 22   HOH HOH A . 
E 4 HOH 75  1575 408  HOH HOH A . 
E 4 HOH 76  1576 215  HOH HOH A . 
E 4 HOH 77  1577 241  HOH HOH A . 
E 4 HOH 78  1578 274  HOH HOH A . 
E 4 HOH 79  1579 51   HOH HOH A . 
E 4 HOH 80  1580 117  HOH HOH A . 
E 4 HOH 81  1581 198  HOH HOH A . 
E 4 HOH 82  1582 39   HOH HOH A . 
E 4 HOH 83  1583 156  HOH HOH A . 
E 4 HOH 84  1584 80   HOH HOH A . 
E 4 HOH 85  1585 113  HOH HOH A . 
E 4 HOH 86  1586 270  HOH HOH A . 
E 4 HOH 87  1587 183  HOH HOH A . 
E 4 HOH 88  1588 24   HOH HOH A . 
E 4 HOH 89  1589 309  HOH HOH A . 
E 4 HOH 90  1590 107  HOH HOH A . 
E 4 HOH 91  1591 164  HOH HOH A . 
E 4 HOH 92  1592 127  HOH HOH A . 
E 4 HOH 93  1593 100  HOH HOH A . 
E 4 HOH 94  1594 44   HOH HOH A . 
E 4 HOH 95  1595 466  HOH HOH A . 
E 4 HOH 96  1596 126  HOH HOH A . 
E 4 HOH 97  1597 73   HOH HOH A . 
E 4 HOH 98  1598 4    HOH HOH A . 
E 4 HOH 99  1599 376  HOH HOH A . 
E 4 HOH 100 1600 47   HOH HOH A . 
E 4 HOH 101 1601 27   HOH HOH A . 
E 4 HOH 102 1602 62   HOH HOH A . 
E 4 HOH 103 1603 430  HOH HOH A . 
E 4 HOH 104 1604 154  HOH HOH A . 
E 4 HOH 105 1605 403  HOH HOH A . 
E 4 HOH 106 1606 16   HOH HOH A . 
E 4 HOH 107 1607 449  HOH HOH A . 
E 4 HOH 108 1608 311  HOH HOH A . 
E 4 HOH 109 1609 356  HOH HOH A . 
E 4 HOH 110 1610 130  HOH HOH A . 
E 4 HOH 111 1611 211  HOH HOH A . 
E 4 HOH 112 1612 15   HOH HOH A . 
E 4 HOH 113 1613 279  HOH HOH A . 
E 4 HOH 114 1614 33   HOH HOH A . 
E 4 HOH 115 1615 3    HOH HOH A . 
E 4 HOH 116 1616 32   HOH HOH A . 
E 4 HOH 117 1617 462  HOH HOH A . 
E 4 HOH 118 1618 69   HOH HOH A . 
E 4 HOH 119 1619 124  HOH HOH A . 
E 4 HOH 120 1620 6    HOH HOH A . 
E 4 HOH 121 1621 137  HOH HOH A . 
E 4 HOH 122 1622 167  HOH HOH A . 
E 4 HOH 123 1623 28   HOH HOH A . 
E 4 HOH 124 1624 13   HOH HOH A . 
E 4 HOH 125 1625 84   HOH HOH A . 
E 4 HOH 126 1626 313  HOH HOH A . 
E 4 HOH 127 1627 152  HOH HOH A . 
E 4 HOH 128 1628 89   HOH HOH A . 
E 4 HOH 129 1629 265  HOH HOH A . 
E 4 HOH 130 1630 149  HOH HOH A . 
E 4 HOH 131 1631 257  HOH HOH A . 
E 4 HOH 132 1632 17   HOH HOH A . 
E 4 HOH 133 1633 213  HOH HOH A . 
E 4 HOH 134 1634 43   HOH HOH A . 
E 4 HOH 135 1635 37   HOH HOH A . 
E 4 HOH 136 1636 20   HOH HOH A . 
E 4 HOH 137 1637 7    HOH HOH A . 
E 4 HOH 138 1638 46   HOH HOH A . 
E 4 HOH 139 1639 280  HOH HOH A . 
E 4 HOH 140 1640 70   HOH HOH A . 
E 4 HOH 141 1641 18   HOH HOH A . 
E 4 HOH 142 1642 106  HOH HOH A . 
E 4 HOH 143 1643 166  HOH HOH A . 
E 4 HOH 144 1644 136  HOH HOH A . 
E 4 HOH 145 1645 332  HOH HOH A . 
E 4 HOH 146 1646 221  HOH HOH A . 
E 4 HOH 147 1647 231  HOH HOH A . 
E 4 HOH 148 1648 235  HOH HOH A . 
E 4 HOH 149 1649 465  HOH HOH A . 
E 4 HOH 150 1650 11   HOH HOH A . 
E 4 HOH 151 1651 299  HOH HOH A . 
E 4 HOH 152 1652 55   HOH HOH A . 
E 4 HOH 153 1653 66   HOH HOH A . 
E 4 HOH 154 1654 76   HOH HOH A . 
E 4 HOH 155 1655 128  HOH HOH A . 
E 4 HOH 156 1656 363  HOH HOH A . 
E 4 HOH 157 1657 19   HOH HOH A . 
E 4 HOH 158 1658 118  HOH HOH A . 
E 4 HOH 159 1659 145  HOH HOH A . 
E 4 HOH 160 1660 161  HOH HOH A . 
E 4 HOH 161 1661 116  HOH HOH A . 
E 4 HOH 162 1662 350  HOH HOH A . 
E 4 HOH 163 1663 460  HOH HOH A . 
E 4 HOH 164 1664 266  HOH HOH A . 
E 4 HOH 165 1665 396  HOH HOH A . 
E 4 HOH 166 1666 87   HOH HOH A . 
E 4 HOH 167 1667 208  HOH HOH A . 
E 4 HOH 168 1668 48   HOH HOH A . 
E 4 HOH 169 1669 134  HOH HOH A . 
E 4 HOH 170 1670 424  HOH HOH A . 
E 4 HOH 171 1671 212  HOH HOH A . 
E 4 HOH 172 1672 353  HOH HOH A . 
E 4 HOH 173 1673 287  HOH HOH A . 
E 4 HOH 174 1674 85   HOH HOH A . 
E 4 HOH 175 1675 121  HOH HOH A . 
E 4 HOH 176 1676 142  HOH HOH A . 
E 4 HOH 177 1677 140  HOH HOH A . 
E 4 HOH 178 1678 225  HOH HOH A . 
E 4 HOH 179 1679 181  HOH HOH A . 
E 4 HOH 180 1680 346  HOH HOH A . 
E 4 HOH 181 1681 79   HOH HOH A . 
E 4 HOH 182 1682 203  HOH HOH A . 
E 4 HOH 183 1683 369  HOH HOH A . 
E 4 HOH 184 1684 83   HOH HOH A . 
E 4 HOH 185 1685 125  HOH HOH A . 
E 4 HOH 186 1686 68   HOH HOH A . 
E 4 HOH 187 1687 434  HOH HOH A . 
E 4 HOH 188 1688 77   HOH HOH A . 
E 4 HOH 189 1689 9    HOH HOH A . 
E 4 HOH 190 1690 23   HOH HOH A . 
E 4 HOH 191 1691 298  HOH HOH A . 
E 4 HOH 192 1692 277  HOH HOH A . 
E 4 HOH 193 1693 92   HOH HOH A . 
E 4 HOH 194 1694 348  HOH HOH A . 
E 4 HOH 195 1695 88   HOH HOH A . 
E 4 HOH 196 1696 64   HOH HOH A . 
E 4 HOH 197 1697 223  HOH HOH A . 
E 4 HOH 198 1698 56   HOH HOH A . 
E 4 HOH 199 1699 57   HOH HOH A . 
E 4 HOH 200 1700 104  HOH HOH A . 
E 4 HOH 201 1701 5    HOH HOH A . 
E 4 HOH 202 1702 431  HOH HOH A . 
E 4 HOH 203 1703 111  HOH HOH A . 
E 4 HOH 204 1704 65   HOH HOH A . 
E 4 HOH 205 1705 143  HOH HOH A . 
E 4 HOH 206 1706 35   HOH HOH A . 
E 4 HOH 207 1707 78   HOH HOH A . 
E 4 HOH 208 1708 60   HOH HOH A . 
E 4 HOH 209 1709 162  HOH HOH A . 
E 4 HOH 210 1710 338  HOH HOH A . 
E 4 HOH 211 1711 150  HOH HOH A . 
E 4 HOH 212 1712 240  HOH HOH A . 
E 4 HOH 213 1713 185  HOH HOH A . 
E 4 HOH 214 1714 101  HOH HOH A . 
E 4 HOH 215 1715 148  HOH HOH A . 
E 4 HOH 216 1716 291  HOH HOH A . 
E 4 HOH 217 1717 384  HOH HOH A . 
E 4 HOH 218 1718 199  HOH HOH A . 
E 4 HOH 219 1719 243  HOH HOH A . 
E 4 HOH 220 1720 74   HOH HOH A . 
E 4 HOH 221 1721 131  HOH HOH A . 
E 4 HOH 222 1722 367  HOH HOH A . 
E 4 HOH 223 1723 123  HOH HOH A . 
E 4 HOH 224 1724 129  HOH HOH A . 
E 4 HOH 225 1725 168  HOH HOH A . 
E 4 HOH 226 1726 272  HOH HOH A . 
E 4 HOH 227 1727 61   HOH HOH A . 
E 4 HOH 228 1728 10   HOH HOH A . 
E 4 HOH 229 1729 209  HOH HOH A . 
E 4 HOH 230 1730 188  HOH HOH A . 
E 4 HOH 231 1731 119  HOH HOH A . 
E 4 HOH 232 1732 204  HOH HOH A . 
E 4 HOH 233 1733 260  HOH HOH A . 
E 4 HOH 234 1734 30   HOH HOH A . 
E 4 HOH 235 1735 469  HOH HOH A . 
E 4 HOH 236 1736 114  HOH HOH A . 
E 4 HOH 237 1737 264  HOH HOH A . 
E 4 HOH 238 1738 228  HOH HOH A . 
E 4 HOH 239 1739 214  HOH HOH A . 
E 4 HOH 240 1740 296  HOH HOH A . 
E 4 HOH 241 1741 205  HOH HOH A . 
E 4 HOH 242 1742 52   HOH HOH A . 
E 4 HOH 243 1743 381  HOH HOH A . 
E 4 HOH 244 1744 40   HOH HOH A . 
E 4 HOH 245 1745 50   HOH HOH A . 
E 4 HOH 246 1746 90   HOH HOH A . 
E 4 HOH 247 1747 115  HOH HOH A . 
E 4 HOH 248 1748 139  HOH HOH A . 
E 4 HOH 249 1749 147  HOH HOH A . 
E 4 HOH 250 1750 400  HOH HOH A . 
E 4 HOH 251 1751 227  HOH HOH A . 
E 4 HOH 252 1752 177  HOH HOH A . 
E 4 HOH 253 1753 316  HOH HOH A . 
E 4 HOH 254 1754 229  HOH HOH A . 
E 4 HOH 255 1755 63   HOH HOH A . 
E 4 HOH 256 1756 255  HOH HOH A . 
E 4 HOH 257 1757 252  HOH HOH A . 
E 4 HOH 258 1758 361  HOH HOH A . 
E 4 HOH 259 1759 470  HOH HOH A . 
E 4 HOH 260 1760 473  HOH HOH A . 
E 4 HOH 261 1761 262  HOH HOH A . 
E 4 HOH 262 1762 38   HOH HOH A . 
E 4 HOH 263 1763 406  HOH HOH A . 
E 4 HOH 264 1764 327  HOH HOH A . 
E 4 HOH 265 1765 345  HOH HOH A . 
E 4 HOH 266 1766 86   HOH HOH A . 
E 4 HOH 267 1767 234  HOH HOH A . 
E 4 HOH 268 1768 343  HOH HOH A . 
E 4 HOH 269 1769 267  HOH HOH A . 
E 4 HOH 270 1770 471  HOH HOH A . 
E 4 HOH 271 1771 239  HOH HOH A . 
E 4 HOH 272 1772 323  HOH HOH A . 
E 4 HOH 273 1773 415  HOH HOH A . 
E 4 HOH 274 1774 326  HOH HOH A . 
E 4 HOH 275 1775 138  HOH HOH A . 
E 4 HOH 276 1776 289  HOH HOH A . 
E 4 HOH 277 1777 314  HOH HOH A . 
E 4 HOH 278 1778 206  HOH HOH A . 
E 4 HOH 279 1779 423  HOH HOH A . 
E 4 HOH 280 1780 288  HOH HOH A . 
E 4 HOH 281 1781 220  HOH HOH A . 
E 4 HOH 282 1782 285  HOH HOH A . 
E 4 HOH 283 1783 179  HOH HOH A . 
E 4 HOH 284 1784 259  HOH HOH A . 
E 4 HOH 285 1785 351  HOH HOH A . 
E 4 HOH 286 1786 442  HOH HOH A . 
E 4 HOH 287 1787 120  HOH HOH A . 
E 4 HOH 288 1788 109  HOH HOH A . 
E 4 HOH 289 1789 269  HOH HOH A . 
E 4 HOH 290 1790 479  HOH HOH A . 
E 4 HOH 291 1791 478  HOH HOH A . 
E 4 HOH 292 1792 250  HOH HOH A . 
E 4 HOH 293 1793 300  HOH HOH A . 
E 4 HOH 294 1794 375  HOH HOH A . 
E 4 HOH 295 1795 339  HOH HOH A . 
E 4 HOH 296 1796 307  HOH HOH A . 
E 4 HOH 297 1797 336  HOH HOH A . 
E 4 HOH 298 1798 394  HOH HOH A . 
E 4 HOH 299 1799 372  HOH HOH A . 
E 4 HOH 300 1800 95   HOH HOH A . 
E 4 HOH 301 1801 453  HOH HOH A . 
E 4 HOH 302 1802 67   HOH HOH A . 
E 4 HOH 303 1803 251  HOH HOH A . 
E 4 HOH 304 1804 374  HOH HOH A . 
E 4 HOH 305 1805 276  HOH HOH A . 
E 4 HOH 306 1806 160  HOH HOH A . 
E 4 HOH 307 1807 278  HOH HOH A . 
E 4 HOH 308 1808 135  HOH HOH A . 
E 4 HOH 309 1809 271  HOH HOH A . 
E 4 HOH 310 1810 445  HOH HOH A . 
E 4 HOH 311 1811 476  HOH HOH A . 
E 4 HOH 312 1812 191  HOH HOH A . 
E 4 HOH 313 1813 388  HOH HOH A . 
E 4 HOH 314 1814 405  HOH HOH A . 
E 4 HOH 315 1815 382  HOH HOH A . 
E 4 HOH 316 1816 397  HOH HOH A . 
E 4 HOH 317 1817 324  HOH HOH A . 
E 4 HOH 318 1818 373  HOH HOH A . 
E 4 HOH 319 1819 437  HOH HOH A . 
E 4 HOH 320 1820 216  HOH HOH A . 
E 4 HOH 321 1821 82   HOH HOH A . 
E 4 HOH 322 1822 359  HOH HOH A . 
E 4 HOH 323 1823 364  HOH HOH A . 
E 4 HOH 324 1824 414  HOH HOH A . 
E 4 HOH 325 1825 463  HOH HOH A . 
E 4 HOH 326 1826 173  HOH HOH A . 
E 4 HOH 327 1827 320  HOH HOH A . 
E 4 HOH 328 1828 389  HOH HOH A . 
E 4 HOH 329 1829 407  HOH HOH A . 
E 4 HOH 330 1830 477  HOH HOH A . 
E 4 HOH 331 1831 467  HOH HOH A . 
E 4 HOH 332 1832 81   HOH HOH A . 
E 4 HOH 333 1833 295  HOH HOH A . 
E 4 HOH 334 1834 322  HOH HOH A . 
E 4 HOH 335 1835 443  HOH HOH A . 
E 4 HOH 336 1836 305  HOH HOH A . 
E 4 HOH 337 1837 245  HOH HOH A . 
E 4 HOH 338 1838 418  HOH HOH A . 
E 4 HOH 339 1839 253  HOH HOH A . 
E 4 HOH 340 1840 218  HOH HOH A . 
E 4 HOH 341 1841 342  HOH HOH A . 
E 4 HOH 342 1842 281  HOH HOH A . 
E 4 HOH 343 1843 355  HOH HOH A . 
E 4 HOH 344 1844 330  HOH HOH A . 
E 4 HOH 345 1845 315  HOH HOH A . 
E 4 HOH 346 1846 196  HOH HOH A . 
E 4 HOH 347 1847 436  HOH HOH A . 
E 4 HOH 348 1848 459  HOH HOH A . 
E 4 HOH 349 1849 202  HOH HOH A . 
E 4 HOH 350 1850 317  HOH HOH A . 
E 4 HOH 351 1851 416  HOH HOH A . 
E 4 HOH 352 1852 321  HOH HOH A . 
E 4 HOH 353 1853 122  HOH HOH A . 
E 4 HOH 354 1854 233  HOH HOH A . 
E 4 HOH 355 1855 354  HOH HOH A . 
E 4 HOH 356 1856 331  HOH HOH A . 
E 4 HOH 357 1857 263  HOH HOH A . 
E 4 HOH 358 1858 165  HOH HOH A . 
E 4 HOH 359 1859 447  HOH HOH A . 
E 4 HOH 360 1860 224  HOH HOH A . 
E 4 HOH 361 1861 194  HOH HOH A . 
E 4 HOH 362 1862 246  HOH HOH A . 
E 4 HOH 363 1863 458  HOH HOH A . 
E 4 HOH 364 1864 261  HOH HOH A . 
E 4 HOH 365 1865 371  HOH HOH A . 
E 4 HOH 366 1866 464  HOH HOH A . 
E 4 HOH 367 1867 413  HOH HOH A . 
E 4 HOH 368 1868 153  HOH HOH A . 
E 4 HOH 369 1869 283  HOH HOH A . 
E 4 HOH 370 1870 366  HOH HOH A . 
E 4 HOH 371 1871 230  HOH HOH A . 
E 4 HOH 372 1872 377  HOH HOH A . 
E 4 HOH 373 1873 457  HOH HOH A . 
E 4 HOH 374 1874 344  HOH HOH A . 
E 4 HOH 375 1875 340  HOH HOH A . 
E 4 HOH 376 1876 362  HOH HOH A . 
E 4 HOH 377 1877 157  HOH HOH A . 
E 4 HOH 378 1878 96   HOH HOH A . 
E 4 HOH 379 1879 193  HOH HOH A . 
E 4 HOH 380 1880 358  HOH HOH A . 
E 4 HOH 381 1881 425  HOH HOH A . 
E 4 HOH 382 1882 175  HOH HOH A . 
E 4 HOH 383 1883 248  HOH HOH A . 
E 4 HOH 384 1884 237  HOH HOH A . 
E 4 HOH 385 1885 391  HOH HOH A . 
E 4 HOH 386 1886 180  HOH HOH A . 
E 4 HOH 387 1887 352  HOH HOH A . 
E 4 HOH 388 1888 254  HOH HOH A . 
E 4 HOH 389 1889 172  HOH HOH A . 
E 4 HOH 390 1890 432  HOH HOH A . 
E 4 HOH 391 1891 105  HOH HOH A . 
E 4 HOH 392 1892 190  HOH HOH A . 
E 4 HOH 393 1893 201  HOH HOH A . 
E 4 HOH 394 1894 247  HOH HOH A . 
E 4 HOH 395 1895 249  HOH HOH A . 
E 4 HOH 396 1896 420  HOH HOH A . 
E 4 HOH 397 1897 290  HOH HOH A . 
E 4 HOH 398 1898 110  HOH HOH A . 
E 4 HOH 399 1899 412  HOH HOH A . 
E 4 HOH 400 1900 222  HOH HOH A . 
E 4 HOH 401 1901 141  HOH HOH A . 
E 4 HOH 402 1902 461  HOH HOH A . 
E 4 HOH 403 1903 472  HOH HOH A . 
E 4 HOH 404 1904 312  HOH HOH A . 
E 4 HOH 405 1905 219  HOH HOH A . 
E 4 HOH 406 1906 333  HOH HOH A . 
E 4 HOH 407 1907 433  HOH HOH A . 
E 4 HOH 408 1908 319  HOH HOH A . 
E 4 HOH 409 1909 294  HOH HOH A . 
E 4 HOH 410 1910 244  HOH HOH A . 
E 4 HOH 411 1911 329  HOH HOH A . 
E 4 HOH 412 1912 475  HOH HOH A . 
E 4 HOH 413 1913 411  HOH HOH A . 
E 4 HOH 414 1914 306  HOH HOH A . 
E 4 HOH 415 1915 217  HOH HOH A . 
E 4 HOH 416 1916 293  HOH HOH A . 
E 4 HOH 417 1917 410  HOH HOH A . 
E 4 HOH 418 1918 210  HOH HOH A . 
E 4 HOH 419 1919 297  HOH HOH A . 
E 4 HOH 420 1920 370  HOH HOH A . 
E 4 HOH 421 1921 429  HOH HOH A . 
E 4 HOH 422 1922 49   HOH HOH A . 
E 4 HOH 423 1923 282  HOH HOH A . 
E 4 HOH 424 1924 189  HOH HOH A . 
E 4 HOH 425 1925 146  HOH HOH A . 
E 4 HOH 426 1926 446  HOH HOH A . 
E 4 HOH 427 1927 238  HOH HOH A . 
E 4 HOH 428 1928 182  HOH HOH A . 
E 4 HOH 429 1929 360  HOH HOH A . 
E 4 HOH 430 1930 273  HOH HOH A . 
E 4 HOH 431 1931 402  HOH HOH A . 
E 4 HOH 432 1932 441  HOH HOH A . 
E 4 HOH 433 1933 480  HOH HOH A . 
E 4 HOH 434 1934 398  HOH HOH A . 
E 4 HOH 435 1935 387  HOH HOH A . 
E 4 HOH 436 1936 439  HOH HOH A . 
E 4 HOH 437 1937 399  HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A ILE 1255 ? CB  ? A ILE 247 CB  
2 1 Y 1 A ILE 1255 ? CG1 ? A ILE 247 CG1 
3 1 Y 1 A ILE 1255 ? CG2 ? A ILE 247 CG2 
4 1 Y 1 A ILE 1255 ? CD1 ? A ILE 247 CD1 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XSCALE ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9L8G 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     59.170 
_cell.length_a_esd                 ? 
_cell.length_b                     59.170 
_cell.length_b_esd                 ? 
_cell.length_c                     186.180 
_cell.length_c_esd                 ? 
_cell.volume                       564503.704 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9L8G 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                154 
_symmetry.space_group_name_Hall            
;P 32 2"
;
_symmetry.space_group_name_H-M             'P 32 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9L8G 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.72 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          54.76 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'BATCH MODE' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'PEG2000 29.5%' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-05-22 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.90000 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SPRING-8 BEAMLINE BL44XU' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.90000 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL44XU 
_diffrn_source.pdbx_synchrotron_site       SPring-8 
# 
_reflns.B_iso_Wilson_estimate                          14.33 
_reflns.entry_id                                       9L8G 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.35 
_reflns.d_resolution_low                               49.41 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     83861 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.8 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                5.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          8.9 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.997 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.35 
_reflns_shell.d_res_low                                     1.37 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.5 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4086 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.644 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               19.71 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9L8G 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.35 
_refine.ls_d_res_low                             49.41 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     83856 
_refine.ls_number_reflns_R_free                  4193 
_refine.ls_number_reflns_R_work                  79663 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.66 
_refine.ls_percent_reflns_R_free                 5.00 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1733 
_refine.ls_R_factor_R_free                       0.1880 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1726 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      5H59 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 18.2723 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1526 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.35 
_refine_hist.d_res_low                        49.41 
_refine_hist.number_atoms_solvent             437 
_refine_hist.number_atoms_total               2939 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2425 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         77 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0071  ? 2846 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.9842  ? 3886 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0897  ? 391  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0086  ? 525  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 12.1565 ? 459  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.35 1.37  . . 154 2590 99.85  . . . . 0.3058 . . . . . . . . . . . 0.3157 
'X-RAY DIFFRACTION' 1.37 1.38  . . 125 2641 99.78  . . . . 0.3006 . . . . . . . . . . . 0.3207 
'X-RAY DIFFRACTION' 1.38 1.40  . . 132 2623 99.96  . . . . 0.2668 . . . . . . . . . . . 0.2880 
'X-RAY DIFFRACTION' 1.40 1.42  . . 137 2625 100.00 . . . . 0.2624 . . . . . . . . . . . 0.2717 
'X-RAY DIFFRACTION' 1.42 1.43  . . 146 2605 100.00 . . . . 0.2479 . . . . . . . . . . . 0.2613 
'X-RAY DIFFRACTION' 1.43 1.45  . . 125 2635 99.89  . . . . 0.2404 . . . . . . . . . . . 0.2834 
'X-RAY DIFFRACTION' 1.45 1.48  . . 135 2655 99.89  . . . . 0.2299 . . . . . . . . . . . 0.2123 
'X-RAY DIFFRACTION' 1.48 1.50  . . 103 2625 99.89  . . . . 0.2211 . . . . . . . . . . . 0.2177 
'X-RAY DIFFRACTION' 1.50 1.52  . . 148 2673 99.96  . . . . 0.2117 . . . . . . . . . . . 0.2453 
'X-RAY DIFFRACTION' 1.52 1.55  . . 131 2615 100.00 . . . . 0.2063 . . . . . . . . . . . 0.2376 
'X-RAY DIFFRACTION' 1.55 1.57  . . 145 2615 99.82  . . . . 0.2042 . . . . . . . . . . . 0.2277 
'X-RAY DIFFRACTION' 1.57 1.60  . . 138 2673 99.82  . . . . 0.2060 . . . . . . . . . . . 0.2035 
'X-RAY DIFFRACTION' 1.60 1.63  . . 122 2610 100.00 . . . . 0.2001 . . . . . . . . . . . 0.2007 
'X-RAY DIFFRACTION' 1.63 1.66  . . 132 2658 99.93  . . . . 0.1942 . . . . . . . . . . . 0.2180 
'X-RAY DIFFRACTION' 1.66 1.70  . . 147 2651 99.96  . . . . 0.1902 . . . . . . . . . . . 0.2048 
'X-RAY DIFFRACTION' 1.70 1.74  . . 149 2646 99.96  . . . . 0.1772 . . . . . . . . . . . 0.1925 
'X-RAY DIFFRACTION' 1.74 1.78  . . 159 2598 100.00 . . . . 0.1809 . . . . . . . . . . . 0.1913 
'X-RAY DIFFRACTION' 1.78 1.83  . . 156 2647 100.00 . . . . 0.1727 . . . . . . . . . . . 0.1648 
'X-RAY DIFFRACTION' 1.83 1.89  . . 171 2621 100.00 . . . . 0.1643 . . . . . . . . . . . 0.1943 
'X-RAY DIFFRACTION' 1.89 1.95  . . 121 2659 99.86  . . . . 0.1600 . . . . . . . . . . . 0.1646 
'X-RAY DIFFRACTION' 1.95 2.02  . . 111 2686 99.82  . . . . 0.1631 . . . . . . . . . . . 0.1767 
'X-RAY DIFFRACTION' 2.02 2.10  . . 139 2675 99.79  . . . . 0.1651 . . . . . . . . . . . 0.1942 
'X-RAY DIFFRACTION' 2.10 2.19  . . 145 2686 99.93  . . . . 0.1607 . . . . . . . . . . . 0.1753 
'X-RAY DIFFRACTION' 2.19 2.31  . . 124 2656 99.78  . . . . 0.1618 . . . . . . . . . . . 0.1804 
'X-RAY DIFFRACTION' 2.31 2.45  . . 174 2657 99.02  . . . . 0.1673 . . . . . . . . . . . 0.1881 
'X-RAY DIFFRACTION' 2.45 2.64  . . 144 2635 98.62  . . . . 0.1612 . . . . . . . . . . . 0.1774 
'X-RAY DIFFRACTION' 2.64 2.91  . . 154 2673 99.30  . . . . 0.1659 . . . . . . . . . . . 0.1987 
'X-RAY DIFFRACTION' 2.91 3.33  . . 160 2713 99.31  . . . . 0.1539 . . . . . . . . . . . 0.1700 
'X-RAY DIFFRACTION' 3.33 4.19  . . 146 2733 99.00  . . . . 0.1356 . . . . . . . . . . . 0.1305 
'X-RAY DIFFRACTION' 4.19 49.41 . . 120 2884 97.25  . . . . 0.1664 . . . . . . . . . . . 0.1948 
# 
_struct.entry_id                     9L8G 
_struct.title                        'R115A mutant of Ferredoxin-NADP+ reductase from maize root - Oxidized form, low X-ray dose' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9L8G 
_struct_keywords.text            'electron transfer, Flavoprotein, OXIDOREDUCTASE' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
E N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    B4G043_MAIZE 
_struct_ref.pdbx_db_accession          B4G043 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SKVSVAPLHLESAKEPPLNTYKPKEPFTATIVSVESLVGPKAPGETCHIVIDHGGNVPYWEGQSYGVIPPGENPKKPGAP
QNVRLYSIASTRYGDNFDGRTGSLCVRRAVYYDPETGKEDPSKNGVCSNFLCNSKPGDKIQLTGPSGKIMLLPEEDPNAT
HIMIATGTGVAPFRGYLRRMFMEDVPNYRFGGLAWLFLGVANSDSLLYDEEFTSYLKQYPDNFRYDKALSREQKNRSGGK
MYVQDKIEEYSDEIFKLLDGGAHIYFCGLKGMMPGIQDTLKKVAERRGESWDQKLAQLKKNKQWHVEVY
;
_struct_ref.pdbx_align_begin           73 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9L8G 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 309 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             B4G043 
_struct_ref_seq.db_align_beg                  73 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  381 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1009 
_struct_ref_seq.pdbx_auth_seq_align_end       1317 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             9L8G 
_struct_ref_seq_dif.mon_id                       ALA 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      107 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   B4G043 
_struct_ref_seq_dif.db_mon_id                    ARG 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          179 
_struct_ref_seq_dif.details                      'engineered mutation' 
_struct_ref_seq_dif.pdbx_auth_seq_num            1115 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1640  ? 
1 MORE         -2    ? 
1 'SSA (A^2)'  14810 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PRO A 7   ? SER A 12  ? PRO A 1015 SER A 1020 5 ? 6  
HELX_P HELX_P2  AA2 ASP A 120 ? ASN A 124 ? ASP A 1128 ASN A 1132 5 ? 5  
HELX_P HELX_P3  AA3 GLY A 125 ? ASN A 133 ? GLY A 1133 ASN A 1141 1 ? 9  
HELX_P HELX_P4  AA4 VAL A 170 ? MET A 182 ? VAL A 1178 MET A 1190 1 ? 13 
HELX_P HELX_P5  AA5 ASN A 202 ? LEU A 206 ? ASN A 1210 LEU A 1214 5 ? 5  
HELX_P HELX_P6  AA6 TYR A 208 ? TYR A 219 ? TYR A 1216 TYR A 1227 1 ? 12 
HELX_P HELX_P7  AA7 TYR A 242 ? TYR A 250 ? TYR A 1250 TYR A 1258 1 ? 9  
HELX_P HELX_P8  AA8 TYR A 250 ? GLY A 260 ? TYR A 1258 GLY A 1268 1 ? 11 
HELX_P HELX_P9  AA9 MET A 272 ? ARG A 287 ? MET A 1280 ARG A 1295 1 ? 16 
HELX_P HELX_P10 AB1 SER A 290 ? ASN A 301 ? SER A 1298 ASN A 1309 1 ? 12 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 ALA 6   A . ? ALA 1014 A PRO 7   A ? PRO 1015 A 1 -3.23 
2 GLY 144 A . ? GLY 1152 A PRO 145 A ? PRO 1153 A 1 -0.17 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 6 ? 
AA2 ? 5 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? parallel      
AA2 3 4 ? parallel      
AA2 4 5 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ARG A 84  ? SER A 87  ? ARG A 1092 SER A 1095 
AA1 2 SER A 64  ? ILE A 68  ? SER A 1072 ILE A 1076 
AA1 3 LYS A 139 ? SER A 146 ? LYS A 1147 SER A 1154 
AA1 4 PHE A 27  ? SER A 36  ? PHE A 1035 SER A 1044 
AA1 5 THR A 46  ? ASP A 52  ? THR A 1054 ASP A 1060 
AA1 6 THR A 101 ? ALA A 107 ? THR A 1109 ALA A 1115 
AA2 1 PHE A 223 ? LEU A 229 ? PHE A 1231 LEU A 1237 
AA2 2 LEU A 193 ? VAL A 200 ? LEU A 1201 VAL A 1208 
AA2 3 THR A 160 ? THR A 166 ? THR A 1168 THR A 1174 
AA2 4 HIS A 263 ? LEU A 269 ? HIS A 1271 LEU A 1277 
AA2 5 TRP A 304 ? TYR A 309 ? TRP A 1312 TYR A 1317 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O ARG A 84  ? O ARG A 1092 N VAL A 67  ? N VAL A 1075 
AA1 2 3 N GLY A 66  ? N GLY A 1074 O THR A 143 ? O THR A 1151 
AA1 3 4 O LEU A 142 ? O LEU A 1150 N PHE A 27  ? N PHE A 1035 
AA1 4 5 N THR A 30  ? N THR A 1038 O ASP A 52  ? O ASP A 1060 
AA1 5 6 N ILE A 51  ? N ILE A 1059 O GLY A 102 ? O GLY A 1110 
AA2 1 2 O ARG A 224 ? O ARG A 1232 N LEU A 196 ? N LEU A 1204 
AA2 2 3 O TRP A 195 ? O TRP A 1203 N MET A 163 ? N MET A 1171 
AA2 3 4 N ILE A 162 ? N ILE A 1170 O HIS A 263 ? O HIS A 1271 
AA2 4 5 N PHE A 266 ? N PHE A 1274 O GLU A 307 ? O GLU A 1315 
# 
_pdbx_entry_details.entry_id                   9L8G 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O   A HOH 1717 ? ? O A HOH 1870 ? ? 2.12 
2 1 O   A HOH 1752 ? ? O A HOH 1857 ? ? 2.12 
3 1 OE1 A GLN 1149 ? B O A HOH 1501 ? ? 2.14 
4 1 O   A HOH 1537 ? ? O A HOH 1756 ? ? 2.16 
5 1 OD1 A ASN 1104 ? A O A HOH 1503 ? ? 2.19 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     1757 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    A 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     1906 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   1_655 
_pdbx_validate_symm_contact.dist              2.19 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z          
2 -y,x-y,z+2/3   
3 -x+y,-x,z+1/3  
4 x-y,-y,-z+1/3  
5 -x,-x+y,-z+2/3 
6 y,x,-z         
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N      N N N 1   
ALA CA     C N S 2   
ALA C      C N N 3   
ALA O      O N N 4   
ALA CB     C N N 5   
ALA OXT    O N N 6   
ALA H      H N N 7   
ALA H2     H N N 8   
ALA HA     H N N 9   
ALA HB1    H N N 10  
ALA HB2    H N N 11  
ALA HB3    H N N 12  
ALA HXT    H N N 13  
ARG N      N N N 14  
ARG CA     C N S 15  
ARG C      C N N 16  
ARG O      O N N 17  
ARG CB     C N N 18  
ARG CG     C N N 19  
ARG CD     C N N 20  
ARG NE     N N N 21  
ARG CZ     C N N 22  
ARG NH1    N N N 23  
ARG NH2    N N N 24  
ARG OXT    O N N 25  
ARG H      H N N 26  
ARG H2     H N N 27  
ARG HA     H N N 28  
ARG HB2    H N N 29  
ARG HB3    H N N 30  
ARG HG2    H N N 31  
ARG HG3    H N N 32  
ARG HD2    H N N 33  
ARG HD3    H N N 34  
ARG HE     H N N 35  
ARG HH11   H N N 36  
ARG HH12   H N N 37  
ARG HH21   H N N 38  
ARG HH22   H N N 39  
ARG HXT    H N N 40  
ASN N      N N N 41  
ASN CA     C N S 42  
ASN C      C N N 43  
ASN O      O N N 44  
ASN CB     C N N 45  
ASN CG     C N N 46  
ASN OD1    O N N 47  
ASN ND2    N N N 48  
ASN OXT    O N N 49  
ASN H      H N N 50  
ASN H2     H N N 51  
ASN HA     H N N 52  
ASN HB2    H N N 53  
ASN HB3    H N N 54  
ASN HD21   H N N 55  
ASN HD22   H N N 56  
ASN HXT    H N N 57  
ASP N      N N N 58  
ASP CA     C N S 59  
ASP C      C N N 60  
ASP O      O N N 61  
ASP CB     C N N 62  
ASP CG     C N N 63  
ASP OD1    O N N 64  
ASP OD2    O N N 65  
ASP OXT    O N N 66  
ASP H      H N N 67  
ASP H2     H N N 68  
ASP HA     H N N 69  
ASP HB2    H N N 70  
ASP HB3    H N N 71  
ASP HD2    H N N 72  
ASP HXT    H N N 73  
CYS N      N N N 74  
CYS CA     C N R 75  
CYS C      C N N 76  
CYS O      O N N 77  
CYS CB     C N N 78  
CYS SG     S N N 79  
CYS OXT    O N N 80  
CYS H      H N N 81  
CYS H2     H N N 82  
CYS HA     H N N 83  
CYS HB2    H N N 84  
CYS HB3    H N N 85  
CYS HG     H N N 86  
CYS HXT    H N N 87  
FAD PA     P N R 88  
FAD O1A    O N N 89  
FAD O2A    O N N 90  
FAD O5B    O N N 91  
FAD C5B    C N N 92  
FAD C4B    C N R 93  
FAD O4B    O N N 94  
FAD C3B    C N S 95  
FAD O3B    O N N 96  
FAD C2B    C N R 97  
FAD O2B    O N N 98  
FAD C1B    C N R 99  
FAD N9A    N Y N 100 
FAD C8A    C Y N 101 
FAD N7A    N Y N 102 
FAD C5A    C Y N 103 
FAD C6A    C Y N 104 
FAD N6A    N N N 105 
FAD N1A    N Y N 106 
FAD C2A    C Y N 107 
FAD N3A    N Y N 108 
FAD C4A    C Y N 109 
FAD N1     N N N 110 
FAD C2     C N N 111 
FAD O2     O N N 112 
FAD N3     N N N 113 
FAD C4     C N N 114 
FAD O4     O N N 115 
FAD C4X    C N N 116 
FAD N5     N N N 117 
FAD C5X    C Y N 118 
FAD C6     C Y N 119 
FAD C7     C Y N 120 
FAD C7M    C N N 121 
FAD C8     C Y N 122 
FAD C8M    C N N 123 
FAD C9     C Y N 124 
FAD C9A    C Y N 125 
FAD N10    N N N 126 
FAD C10    C N N 127 
FAD "C1'"  C N N 128 
FAD "C2'"  C N S 129 
FAD "O2'"  O N N 130 
FAD "C3'"  C N S 131 
FAD "O3'"  O N N 132 
FAD "C4'"  C N R 133 
FAD "O4'"  O N N 134 
FAD "C5'"  C N N 135 
FAD "O5'"  O N N 136 
FAD P      P N R 137 
FAD O1P    O N N 138 
FAD O2P    O N N 139 
FAD O3P    O N N 140 
FAD HOA2   H N N 141 
FAD H51A   H N N 142 
FAD H52A   H N N 143 
FAD H4B    H N N 144 
FAD H3B    H N N 145 
FAD HO3A   H N N 146 
FAD H2B    H N N 147 
FAD HO2A   H N N 148 
FAD H1B    H N N 149 
FAD H8A    H N N 150 
FAD H61A   H N N 151 
FAD H62A   H N N 152 
FAD H2A    H N N 153 
FAD HN3    H N N 154 
FAD H6     H N N 155 
FAD HM71   H N N 156 
FAD HM72   H N N 157 
FAD HM73   H N N 158 
FAD HM81   H N N 159 
FAD HM82   H N N 160 
FAD HM83   H N N 161 
FAD H9     H N N 162 
FAD "H1'1" H N N 163 
FAD "H1'2" H N N 164 
FAD "H2'"  H N N 165 
FAD "HO2'" H N N 166 
FAD "H3'"  H N N 167 
FAD "HO3'" H N N 168 
FAD "H4'"  H N N 169 
FAD "HO4'" H N N 170 
FAD "H5'1" H N N 171 
FAD "H5'2" H N N 172 
FAD HOP2   H N N 173 
GLN N      N N N 174 
GLN CA     C N S 175 
GLN C      C N N 176 
GLN O      O N N 177 
GLN CB     C N N 178 
GLN CG     C N N 179 
GLN CD     C N N 180 
GLN OE1    O N N 181 
GLN NE2    N N N 182 
GLN OXT    O N N 183 
GLN H      H N N 184 
GLN H2     H N N 185 
GLN HA     H N N 186 
GLN HB2    H N N 187 
GLN HB3    H N N 188 
GLN HG2    H N N 189 
GLN HG3    H N N 190 
GLN HE21   H N N 191 
GLN HE22   H N N 192 
GLN HXT    H N N 193 
GLU N      N N N 194 
GLU CA     C N S 195 
GLU C      C N N 196 
GLU O      O N N 197 
GLU CB     C N N 198 
GLU CG     C N N 199 
GLU CD     C N N 200 
GLU OE1    O N N 201 
GLU OE2    O N N 202 
GLU OXT    O N N 203 
GLU H      H N N 204 
GLU H2     H N N 205 
GLU HA     H N N 206 
GLU HB2    H N N 207 
GLU HB3    H N N 208 
GLU HG2    H N N 209 
GLU HG3    H N N 210 
GLU HE2    H N N 211 
GLU HXT    H N N 212 
GLY N      N N N 213 
GLY CA     C N N 214 
GLY C      C N N 215 
GLY O      O N N 216 
GLY OXT    O N N 217 
GLY H      H N N 218 
GLY H2     H N N 219 
GLY HA2    H N N 220 
GLY HA3    H N N 221 
GLY HXT    H N N 222 
HIS N      N N N 223 
HIS CA     C N S 224 
HIS C      C N N 225 
HIS O      O N N 226 
HIS CB     C N N 227 
HIS CG     C Y N 228 
HIS ND1    N Y N 229 
HIS CD2    C Y N 230 
HIS CE1    C Y N 231 
HIS NE2    N Y N 232 
HIS OXT    O N N 233 
HIS H      H N N 234 
HIS H2     H N N 235 
HIS HA     H N N 236 
HIS HB2    H N N 237 
HIS HB3    H N N 238 
HIS HD1    H N N 239 
HIS HD2    H N N 240 
HIS HE1    H N N 241 
HIS HE2    H N N 242 
HIS HXT    H N N 243 
HOH O      O N N 244 
HOH H1     H N N 245 
HOH H2     H N N 246 
ILE N      N N N 247 
ILE CA     C N S 248 
ILE C      C N N 249 
ILE O      O N N 250 
ILE CB     C N S 251 
ILE CG1    C N N 252 
ILE CG2    C N N 253 
ILE CD1    C N N 254 
ILE OXT    O N N 255 
ILE H      H N N 256 
ILE H2     H N N 257 
ILE HA     H N N 258 
ILE HB     H N N 259 
ILE HG12   H N N 260 
ILE HG13   H N N 261 
ILE HG21   H N N 262 
ILE HG22   H N N 263 
ILE HG23   H N N 264 
ILE HD11   H N N 265 
ILE HD12   H N N 266 
ILE HD13   H N N 267 
ILE HXT    H N N 268 
LEU N      N N N 269 
LEU CA     C N S 270 
LEU C      C N N 271 
LEU O      O N N 272 
LEU CB     C N N 273 
LEU CG     C N N 274 
LEU CD1    C N N 275 
LEU CD2    C N N 276 
LEU OXT    O N N 277 
LEU H      H N N 278 
LEU H2     H N N 279 
LEU HA     H N N 280 
LEU HB2    H N N 281 
LEU HB3    H N N 282 
LEU HG     H N N 283 
LEU HD11   H N N 284 
LEU HD12   H N N 285 
LEU HD13   H N N 286 
LEU HD21   H N N 287 
LEU HD22   H N N 288 
LEU HD23   H N N 289 
LEU HXT    H N N 290 
LYS N      N N N 291 
LYS CA     C N S 292 
LYS C      C N N 293 
LYS O      O N N 294 
LYS CB     C N N 295 
LYS CG     C N N 296 
LYS CD     C N N 297 
LYS CE     C N N 298 
LYS NZ     N N N 299 
LYS OXT    O N N 300 
LYS H      H N N 301 
LYS H2     H N N 302 
LYS HA     H N N 303 
LYS HB2    H N N 304 
LYS HB3    H N N 305 
LYS HG2    H N N 306 
LYS HG3    H N N 307 
LYS HD2    H N N 308 
LYS HD3    H N N 309 
LYS HE2    H N N 310 
LYS HE3    H N N 311 
LYS HZ1    H N N 312 
LYS HZ2    H N N 313 
LYS HZ3    H N N 314 
LYS HXT    H N N 315 
MES O1     O N N 316 
MES C2     C N N 317 
MES C3     C N N 318 
MES N4     N N N 319 
MES C5     C N N 320 
MES C6     C N N 321 
MES C7     C N N 322 
MES C8     C N N 323 
MES S      S N N 324 
MES O1S    O N N 325 
MES O2S    O N N 326 
MES O3S    O N N 327 
MES H21    H N N 328 
MES H22    H N N 329 
MES H31    H N N 330 
MES H32    H N N 331 
MES HN4    H N N 332 
MES H51    H N N 333 
MES H52    H N N 334 
MES H61    H N N 335 
MES H62    H N N 336 
MES H71    H N N 337 
MES H72    H N N 338 
MES H81    H N N 339 
MES H82    H N N 340 
MET N      N N N 341 
MET CA     C N S 342 
MET C      C N N 343 
MET O      O N N 344 
MET CB     C N N 345 
MET CG     C N N 346 
MET SD     S N N 347 
MET CE     C N N 348 
MET OXT    O N N 349 
MET H      H N N 350 
MET H2     H N N 351 
MET HA     H N N 352 
MET HB2    H N N 353 
MET HB3    H N N 354 
MET HG2    H N N 355 
MET HG3    H N N 356 
MET HE1    H N N 357 
MET HE2    H N N 358 
MET HE3    H N N 359 
MET HXT    H N N 360 
PHE N      N N N 361 
PHE CA     C N S 362 
PHE C      C N N 363 
PHE O      O N N 364 
PHE CB     C N N 365 
PHE CG     C Y N 366 
PHE CD1    C Y N 367 
PHE CD2    C Y N 368 
PHE CE1    C Y N 369 
PHE CE2    C Y N 370 
PHE CZ     C Y N 371 
PHE OXT    O N N 372 
PHE H      H N N 373 
PHE H2     H N N 374 
PHE HA     H N N 375 
PHE HB2    H N N 376 
PHE HB3    H N N 377 
PHE HD1    H N N 378 
PHE HD2    H N N 379 
PHE HE1    H N N 380 
PHE HE2    H N N 381 
PHE HZ     H N N 382 
PHE HXT    H N N 383 
PRO N      N N N 384 
PRO CA     C N S 385 
PRO C      C N N 386 
PRO O      O N N 387 
PRO CB     C N N 388 
PRO CG     C N N 389 
PRO CD     C N N 390 
PRO OXT    O N N 391 
PRO H      H N N 392 
PRO HA     H N N 393 
PRO HB2    H N N 394 
PRO HB3    H N N 395 
PRO HG2    H N N 396 
PRO HG3    H N N 397 
PRO HD2    H N N 398 
PRO HD3    H N N 399 
PRO HXT    H N N 400 
SER N      N N N 401 
SER CA     C N S 402 
SER C      C N N 403 
SER O      O N N 404 
SER CB     C N N 405 
SER OG     O N N 406 
SER OXT    O N N 407 
SER H      H N N 408 
SER H2     H N N 409 
SER HA     H N N 410 
SER HB2    H N N 411 
SER HB3    H N N 412 
SER HG     H N N 413 
SER HXT    H N N 414 
THR N      N N N 415 
THR CA     C N S 416 
THR C      C N N 417 
THR O      O N N 418 
THR CB     C N R 419 
THR OG1    O N N 420 
THR CG2    C N N 421 
THR OXT    O N N 422 
THR H      H N N 423 
THR H2     H N N 424 
THR HA     H N N 425 
THR HB     H N N 426 
THR HG1    H N N 427 
THR HG21   H N N 428 
THR HG22   H N N 429 
THR HG23   H N N 430 
THR HXT    H N N 431 
TRP N      N N N 432 
TRP CA     C N S 433 
TRP C      C N N 434 
TRP O      O N N 435 
TRP CB     C N N 436 
TRP CG     C Y N 437 
TRP CD1    C Y N 438 
TRP CD2    C Y N 439 
TRP NE1    N Y N 440 
TRP CE2    C Y N 441 
TRP CE3    C Y N 442 
TRP CZ2    C Y N 443 
TRP CZ3    C Y N 444 
TRP CH2    C Y N 445 
TRP OXT    O N N 446 
TRP H      H N N 447 
TRP H2     H N N 448 
TRP HA     H N N 449 
TRP HB2    H N N 450 
TRP HB3    H N N 451 
TRP HD1    H N N 452 
TRP HE1    H N N 453 
TRP HE3    H N N 454 
TRP HZ2    H N N 455 
TRP HZ3    H N N 456 
TRP HH2    H N N 457 
TRP HXT    H N N 458 
TYR N      N N N 459 
TYR CA     C N S 460 
TYR C      C N N 461 
TYR O      O N N 462 
TYR CB     C N N 463 
TYR CG     C Y N 464 
TYR CD1    C Y N 465 
TYR CD2    C Y N 466 
TYR CE1    C Y N 467 
TYR CE2    C Y N 468 
TYR CZ     C Y N 469 
TYR OH     O N N 470 
TYR OXT    O N N 471 
TYR H      H N N 472 
TYR H2     H N N 473 
TYR HA     H N N 474 
TYR HB2    H N N 475 
TYR HB3    H N N 476 
TYR HD1    H N N 477 
TYR HD2    H N N 478 
TYR HE1    H N N 479 
TYR HE2    H N N 480 
TYR HH     H N N 481 
TYR HXT    H N N 482 
VAL N      N N N 483 
VAL CA     C N S 484 
VAL C      C N N 485 
VAL O      O N N 486 
VAL CB     C N N 487 
VAL CG1    C N N 488 
VAL CG2    C N N 489 
VAL OXT    O N N 490 
VAL H      H N N 491 
VAL H2     H N N 492 
VAL HA     H N N 493 
VAL HB     H N N 494 
VAL HG11   H N N 495 
VAL HG12   H N N 496 
VAL HG13   H N N 497 
VAL HG21   H N N 498 
VAL HG22   H N N 499 
VAL HG23   H N N 500 
VAL HXT    H N N 501 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N     CA     sing N N 1   
ALA N     H      sing N N 2   
ALA N     H2     sing N N 3   
ALA CA    C      sing N N 4   
ALA CA    CB     sing N N 5   
ALA CA    HA     sing N N 6   
ALA C     O      doub N N 7   
ALA C     OXT    sing N N 8   
ALA CB    HB1    sing N N 9   
ALA CB    HB2    sing N N 10  
ALA CB    HB3    sing N N 11  
ALA OXT   HXT    sing N N 12  
ARG N     CA     sing N N 13  
ARG N     H      sing N N 14  
ARG N     H2     sing N N 15  
ARG CA    C      sing N N 16  
ARG CA    CB     sing N N 17  
ARG CA    HA     sing N N 18  
ARG C     O      doub N N 19  
ARG C     OXT    sing N N 20  
ARG CB    CG     sing N N 21  
ARG CB    HB2    sing N N 22  
ARG CB    HB3    sing N N 23  
ARG CG    CD     sing N N 24  
ARG CG    HG2    sing N N 25  
ARG CG    HG3    sing N N 26  
ARG CD    NE     sing N N 27  
ARG CD    HD2    sing N N 28  
ARG CD    HD3    sing N N 29  
ARG NE    CZ     sing N N 30  
ARG NE    HE     sing N N 31  
ARG CZ    NH1    sing N N 32  
ARG CZ    NH2    doub N N 33  
ARG NH1   HH11   sing N N 34  
ARG NH1   HH12   sing N N 35  
ARG NH2   HH21   sing N N 36  
ARG NH2   HH22   sing N N 37  
ARG OXT   HXT    sing N N 38  
ASN N     CA     sing N N 39  
ASN N     H      sing N N 40  
ASN N     H2     sing N N 41  
ASN CA    C      sing N N 42  
ASN CA    CB     sing N N 43  
ASN CA    HA     sing N N 44  
ASN C     O      doub N N 45  
ASN C     OXT    sing N N 46  
ASN CB    CG     sing N N 47  
ASN CB    HB2    sing N N 48  
ASN CB    HB3    sing N N 49  
ASN CG    OD1    doub N N 50  
ASN CG    ND2    sing N N 51  
ASN ND2   HD21   sing N N 52  
ASN ND2   HD22   sing N N 53  
ASN OXT   HXT    sing N N 54  
ASP N     CA     sing N N 55  
ASP N     H      sing N N 56  
ASP N     H2     sing N N 57  
ASP CA    C      sing N N 58  
ASP CA    CB     sing N N 59  
ASP CA    HA     sing N N 60  
ASP C     O      doub N N 61  
ASP C     OXT    sing N N 62  
ASP CB    CG     sing N N 63  
ASP CB    HB2    sing N N 64  
ASP CB    HB3    sing N N 65  
ASP CG    OD1    doub N N 66  
ASP CG    OD2    sing N N 67  
ASP OD2   HD2    sing N N 68  
ASP OXT   HXT    sing N N 69  
CYS N     CA     sing N N 70  
CYS N     H      sing N N 71  
CYS N     H2     sing N N 72  
CYS CA    C      sing N N 73  
CYS CA    CB     sing N N 74  
CYS CA    HA     sing N N 75  
CYS C     O      doub N N 76  
CYS C     OXT    sing N N 77  
CYS CB    SG     sing N N 78  
CYS CB    HB2    sing N N 79  
CYS CB    HB3    sing N N 80  
CYS SG    HG     sing N N 81  
CYS OXT   HXT    sing N N 82  
FAD PA    O1A    doub N N 83  
FAD PA    O2A    sing N N 84  
FAD PA    O5B    sing N N 85  
FAD PA    O3P    sing N N 86  
FAD O2A   HOA2   sing N N 87  
FAD O5B   C5B    sing N N 88  
FAD C5B   C4B    sing N N 89  
FAD C5B   H51A   sing N N 90  
FAD C5B   H52A   sing N N 91  
FAD C4B   O4B    sing N N 92  
FAD C4B   C3B    sing N N 93  
FAD C4B   H4B    sing N N 94  
FAD O4B   C1B    sing N N 95  
FAD C3B   O3B    sing N N 96  
FAD C3B   C2B    sing N N 97  
FAD C3B   H3B    sing N N 98  
FAD O3B   HO3A   sing N N 99  
FAD C2B   O2B    sing N N 100 
FAD C2B   C1B    sing N N 101 
FAD C2B   H2B    sing N N 102 
FAD O2B   HO2A   sing N N 103 
FAD C1B   N9A    sing N N 104 
FAD C1B   H1B    sing N N 105 
FAD N9A   C8A    sing Y N 106 
FAD N9A   C4A    sing Y N 107 
FAD C8A   N7A    doub Y N 108 
FAD C8A   H8A    sing N N 109 
FAD N7A   C5A    sing Y N 110 
FAD C5A   C6A    sing Y N 111 
FAD C5A   C4A    doub Y N 112 
FAD C6A   N6A    sing N N 113 
FAD C6A   N1A    doub Y N 114 
FAD N6A   H61A   sing N N 115 
FAD N6A   H62A   sing N N 116 
FAD N1A   C2A    sing Y N 117 
FAD C2A   N3A    doub Y N 118 
FAD C2A   H2A    sing N N 119 
FAD N3A   C4A    sing Y N 120 
FAD N1    C2     sing N N 121 
FAD N1    C10    doub N N 122 
FAD C2    O2     doub N N 123 
FAD C2    N3     sing N N 124 
FAD N3    C4     sing N N 125 
FAD N3    HN3    sing N N 126 
FAD C4    O4     doub N N 127 
FAD C4    C4X    sing N N 128 
FAD C4X   N5     doub N N 129 
FAD C4X   C10    sing N N 130 
FAD N5    C5X    sing N N 131 
FAD C5X   C6     doub Y N 132 
FAD C5X   C9A    sing Y N 133 
FAD C6    C7     sing Y N 134 
FAD C6    H6     sing N N 135 
FAD C7    C7M    sing N N 136 
FAD C7    C8     doub Y N 137 
FAD C7M   HM71   sing N N 138 
FAD C7M   HM72   sing N N 139 
FAD C7M   HM73   sing N N 140 
FAD C8    C8M    sing N N 141 
FAD C8    C9     sing Y N 142 
FAD C8M   HM81   sing N N 143 
FAD C8M   HM82   sing N N 144 
FAD C8M   HM83   sing N N 145 
FAD C9    C9A    doub Y N 146 
FAD C9    H9     sing N N 147 
FAD C9A   N10    sing N N 148 
FAD N10   C10    sing N N 149 
FAD N10   "C1'"  sing N N 150 
FAD "C1'" "C2'"  sing N N 151 
FAD "C1'" "H1'1" sing N N 152 
FAD "C1'" "H1'2" sing N N 153 
FAD "C2'" "O2'"  sing N N 154 
FAD "C2'" "C3'"  sing N N 155 
FAD "C2'" "H2'"  sing N N 156 
FAD "O2'" "HO2'" sing N N 157 
FAD "C3'" "O3'"  sing N N 158 
FAD "C3'" "C4'"  sing N N 159 
FAD "C3'" "H3'"  sing N N 160 
FAD "O3'" "HO3'" sing N N 161 
FAD "C4'" "O4'"  sing N N 162 
FAD "C4'" "C5'"  sing N N 163 
FAD "C4'" "H4'"  sing N N 164 
FAD "O4'" "HO4'" sing N N 165 
FAD "C5'" "O5'"  sing N N 166 
FAD "C5'" "H5'1" sing N N 167 
FAD "C5'" "H5'2" sing N N 168 
FAD "O5'" P      sing N N 169 
FAD P     O1P    doub N N 170 
FAD P     O2P    sing N N 171 
FAD P     O3P    sing N N 172 
FAD O2P   HOP2   sing N N 173 
GLN N     CA     sing N N 174 
GLN N     H      sing N N 175 
GLN N     H2     sing N N 176 
GLN CA    C      sing N N 177 
GLN CA    CB     sing N N 178 
GLN CA    HA     sing N N 179 
GLN C     O      doub N N 180 
GLN C     OXT    sing N N 181 
GLN CB    CG     sing N N 182 
GLN CB    HB2    sing N N 183 
GLN CB    HB3    sing N N 184 
GLN CG    CD     sing N N 185 
GLN CG    HG2    sing N N 186 
GLN CG    HG3    sing N N 187 
GLN CD    OE1    doub N N 188 
GLN CD    NE2    sing N N 189 
GLN NE2   HE21   sing N N 190 
GLN NE2   HE22   sing N N 191 
GLN OXT   HXT    sing N N 192 
GLU N     CA     sing N N 193 
GLU N     H      sing N N 194 
GLU N     H2     sing N N 195 
GLU CA    C      sing N N 196 
GLU CA    CB     sing N N 197 
GLU CA    HA     sing N N 198 
GLU C     O      doub N N 199 
GLU C     OXT    sing N N 200 
GLU CB    CG     sing N N 201 
GLU CB    HB2    sing N N 202 
GLU CB    HB3    sing N N 203 
GLU CG    CD     sing N N 204 
GLU CG    HG2    sing N N 205 
GLU CG    HG3    sing N N 206 
GLU CD    OE1    doub N N 207 
GLU CD    OE2    sing N N 208 
GLU OE2   HE2    sing N N 209 
GLU OXT   HXT    sing N N 210 
GLY N     CA     sing N N 211 
GLY N     H      sing N N 212 
GLY N     H2     sing N N 213 
GLY CA    C      sing N N 214 
GLY CA    HA2    sing N N 215 
GLY CA    HA3    sing N N 216 
GLY C     O      doub N N 217 
GLY C     OXT    sing N N 218 
GLY OXT   HXT    sing N N 219 
HIS N     CA     sing N N 220 
HIS N     H      sing N N 221 
HIS N     H2     sing N N 222 
HIS CA    C      sing N N 223 
HIS CA    CB     sing N N 224 
HIS CA    HA     sing N N 225 
HIS C     O      doub N N 226 
HIS C     OXT    sing N N 227 
HIS CB    CG     sing N N 228 
HIS CB    HB2    sing N N 229 
HIS CB    HB3    sing N N 230 
HIS CG    ND1    sing Y N 231 
HIS CG    CD2    doub Y N 232 
HIS ND1   CE1    doub Y N 233 
HIS ND1   HD1    sing N N 234 
HIS CD2   NE2    sing Y N 235 
HIS CD2   HD2    sing N N 236 
HIS CE1   NE2    sing Y N 237 
HIS CE1   HE1    sing N N 238 
HIS NE2   HE2    sing N N 239 
HIS OXT   HXT    sing N N 240 
HOH O     H1     sing N N 241 
HOH O     H2     sing N N 242 
ILE N     CA     sing N N 243 
ILE N     H      sing N N 244 
ILE N     H2     sing N N 245 
ILE CA    C      sing N N 246 
ILE CA    CB     sing N N 247 
ILE CA    HA     sing N N 248 
ILE C     O      doub N N 249 
ILE C     OXT    sing N N 250 
ILE CB    CG1    sing N N 251 
ILE CB    CG2    sing N N 252 
ILE CB    HB     sing N N 253 
ILE CG1   CD1    sing N N 254 
ILE CG1   HG12   sing N N 255 
ILE CG1   HG13   sing N N 256 
ILE CG2   HG21   sing N N 257 
ILE CG2   HG22   sing N N 258 
ILE CG2   HG23   sing N N 259 
ILE CD1   HD11   sing N N 260 
ILE CD1   HD12   sing N N 261 
ILE CD1   HD13   sing N N 262 
ILE OXT   HXT    sing N N 263 
LEU N     CA     sing N N 264 
LEU N     H      sing N N 265 
LEU N     H2     sing N N 266 
LEU CA    C      sing N N 267 
LEU CA    CB     sing N N 268 
LEU CA    HA     sing N N 269 
LEU C     O      doub N N 270 
LEU C     OXT    sing N N 271 
LEU CB    CG     sing N N 272 
LEU CB    HB2    sing N N 273 
LEU CB    HB3    sing N N 274 
LEU CG    CD1    sing N N 275 
LEU CG    CD2    sing N N 276 
LEU CG    HG     sing N N 277 
LEU CD1   HD11   sing N N 278 
LEU CD1   HD12   sing N N 279 
LEU CD1   HD13   sing N N 280 
LEU CD2   HD21   sing N N 281 
LEU CD2   HD22   sing N N 282 
LEU CD2   HD23   sing N N 283 
LEU OXT   HXT    sing N N 284 
LYS N     CA     sing N N 285 
LYS N     H      sing N N 286 
LYS N     H2     sing N N 287 
LYS CA    C      sing N N 288 
LYS CA    CB     sing N N 289 
LYS CA    HA     sing N N 290 
LYS C     O      doub N N 291 
LYS C     OXT    sing N N 292 
LYS CB    CG     sing N N 293 
LYS CB    HB2    sing N N 294 
LYS CB    HB3    sing N N 295 
LYS CG    CD     sing N N 296 
LYS CG    HG2    sing N N 297 
LYS CG    HG3    sing N N 298 
LYS CD    CE     sing N N 299 
LYS CD    HD2    sing N N 300 
LYS CD    HD3    sing N N 301 
LYS CE    NZ     sing N N 302 
LYS CE    HE2    sing N N 303 
LYS CE    HE3    sing N N 304 
LYS NZ    HZ1    sing N N 305 
LYS NZ    HZ2    sing N N 306 
LYS NZ    HZ3    sing N N 307 
LYS OXT   HXT    sing N N 308 
MES O1    C2     sing N N 309 
MES O1    C6     sing N N 310 
MES C2    C3     sing N N 311 
MES C2    H21    sing N N 312 
MES C2    H22    sing N N 313 
MES C3    N4     sing N N 314 
MES C3    H31    sing N N 315 
MES C3    H32    sing N N 316 
MES N4    C5     sing N N 317 
MES N4    C7     sing N N 318 
MES N4    HN4    sing N N 319 
MES C5    C6     sing N N 320 
MES C5    H51    sing N N 321 
MES C5    H52    sing N N 322 
MES C6    H61    sing N N 323 
MES C6    H62    sing N N 324 
MES C7    C8     sing N N 325 
MES C7    H71    sing N N 326 
MES C7    H72    sing N N 327 
MES C8    S      sing N N 328 
MES C8    H81    sing N N 329 
MES C8    H82    sing N N 330 
MES S     O1S    doub N N 331 
MES S     O2S    doub N N 332 
MES S     O3S    sing N N 333 
MET N     CA     sing N N 334 
MET N     H      sing N N 335 
MET N     H2     sing N N 336 
MET CA    C      sing N N 337 
MET CA    CB     sing N N 338 
MET CA    HA     sing N N 339 
MET C     O      doub N N 340 
MET C     OXT    sing N N 341 
MET CB    CG     sing N N 342 
MET CB    HB2    sing N N 343 
MET CB    HB3    sing N N 344 
MET CG    SD     sing N N 345 
MET CG    HG2    sing N N 346 
MET CG    HG3    sing N N 347 
MET SD    CE     sing N N 348 
MET CE    HE1    sing N N 349 
MET CE    HE2    sing N N 350 
MET CE    HE3    sing N N 351 
MET OXT   HXT    sing N N 352 
PHE N     CA     sing N N 353 
PHE N     H      sing N N 354 
PHE N     H2     sing N N 355 
PHE CA    C      sing N N 356 
PHE CA    CB     sing N N 357 
PHE CA    HA     sing N N 358 
PHE C     O      doub N N 359 
PHE C     OXT    sing N N 360 
PHE CB    CG     sing N N 361 
PHE CB    HB2    sing N N 362 
PHE CB    HB3    sing N N 363 
PHE CG    CD1    doub Y N 364 
PHE CG    CD2    sing Y N 365 
PHE CD1   CE1    sing Y N 366 
PHE CD1   HD1    sing N N 367 
PHE CD2   CE2    doub Y N 368 
PHE CD2   HD2    sing N N 369 
PHE CE1   CZ     doub Y N 370 
PHE CE1   HE1    sing N N 371 
PHE CE2   CZ     sing Y N 372 
PHE CE2   HE2    sing N N 373 
PHE CZ    HZ     sing N N 374 
PHE OXT   HXT    sing N N 375 
PRO N     CA     sing N N 376 
PRO N     CD     sing N N 377 
PRO N     H      sing N N 378 
PRO CA    C      sing N N 379 
PRO CA    CB     sing N N 380 
PRO CA    HA     sing N N 381 
PRO C     O      doub N N 382 
PRO C     OXT    sing N N 383 
PRO CB    CG     sing N N 384 
PRO CB    HB2    sing N N 385 
PRO CB    HB3    sing N N 386 
PRO CG    CD     sing N N 387 
PRO CG    HG2    sing N N 388 
PRO CG    HG3    sing N N 389 
PRO CD    HD2    sing N N 390 
PRO CD    HD3    sing N N 391 
PRO OXT   HXT    sing N N 392 
SER N     CA     sing N N 393 
SER N     H      sing N N 394 
SER N     H2     sing N N 395 
SER CA    C      sing N N 396 
SER CA    CB     sing N N 397 
SER CA    HA     sing N N 398 
SER C     O      doub N N 399 
SER C     OXT    sing N N 400 
SER CB    OG     sing N N 401 
SER CB    HB2    sing N N 402 
SER CB    HB3    sing N N 403 
SER OG    HG     sing N N 404 
SER OXT   HXT    sing N N 405 
THR N     CA     sing N N 406 
THR N     H      sing N N 407 
THR N     H2     sing N N 408 
THR CA    C      sing N N 409 
THR CA    CB     sing N N 410 
THR CA    HA     sing N N 411 
THR C     O      doub N N 412 
THR C     OXT    sing N N 413 
THR CB    OG1    sing N N 414 
THR CB    CG2    sing N N 415 
THR CB    HB     sing N N 416 
THR OG1   HG1    sing N N 417 
THR CG2   HG21   sing N N 418 
THR CG2   HG22   sing N N 419 
THR CG2   HG23   sing N N 420 
THR OXT   HXT    sing N N 421 
TRP N     CA     sing N N 422 
TRP N     H      sing N N 423 
TRP N     H2     sing N N 424 
TRP CA    C      sing N N 425 
TRP CA    CB     sing N N 426 
TRP CA    HA     sing N N 427 
TRP C     O      doub N N 428 
TRP C     OXT    sing N N 429 
TRP CB    CG     sing N N 430 
TRP CB    HB2    sing N N 431 
TRP CB    HB3    sing N N 432 
TRP CG    CD1    doub Y N 433 
TRP CG    CD2    sing Y N 434 
TRP CD1   NE1    sing Y N 435 
TRP CD1   HD1    sing N N 436 
TRP CD2   CE2    doub Y N 437 
TRP CD2   CE3    sing Y N 438 
TRP NE1   CE2    sing Y N 439 
TRP NE1   HE1    sing N N 440 
TRP CE2   CZ2    sing Y N 441 
TRP CE3   CZ3    doub Y N 442 
TRP CE3   HE3    sing N N 443 
TRP CZ2   CH2    doub Y N 444 
TRP CZ2   HZ2    sing N N 445 
TRP CZ3   CH2    sing Y N 446 
TRP CZ3   HZ3    sing N N 447 
TRP CH2   HH2    sing N N 448 
TRP OXT   HXT    sing N N 449 
TYR N     CA     sing N N 450 
TYR N     H      sing N N 451 
TYR N     H2     sing N N 452 
TYR CA    C      sing N N 453 
TYR CA    CB     sing N N 454 
TYR CA    HA     sing N N 455 
TYR C     O      doub N N 456 
TYR C     OXT    sing N N 457 
TYR CB    CG     sing N N 458 
TYR CB    HB2    sing N N 459 
TYR CB    HB3    sing N N 460 
TYR CG    CD1    doub Y N 461 
TYR CG    CD2    sing Y N 462 
TYR CD1   CE1    sing Y N 463 
TYR CD1   HD1    sing N N 464 
TYR CD2   CE2    doub Y N 465 
TYR CD2   HD2    sing N N 466 
TYR CE1   CZ     doub Y N 467 
TYR CE1   HE1    sing N N 468 
TYR CE2   CZ     sing Y N 469 
TYR CE2   HE2    sing N N 470 
TYR CZ    OH     sing N N 471 
TYR OH    HH     sing N N 472 
TYR OXT   HXT    sing N N 473 
VAL N     CA     sing N N 474 
VAL N     H      sing N N 475 
VAL N     H2     sing N N 476 
VAL CA    C      sing N N 477 
VAL CA    CB     sing N N 478 
VAL CA    HA     sing N N 479 
VAL C     O      doub N N 480 
VAL C     OXT    sing N N 481 
VAL CB    CG1    sing N N 482 
VAL CB    CG2    sing N N 483 
VAL CB    HB     sing N N 484 
VAL CG1   HG11   sing N N 485 
VAL CG1   HG12   sing N N 486 
VAL CG1   HG13   sing N N 487 
VAL CG2   HG21   sing N N 488 
VAL CG2   HG22   sing N N 489 
VAL CG2   HG23   sing N N 490 
VAL OXT   HXT    sing N N 491 
# 
_pdbx_audit_support.funding_organization   'Japan Science and Technology' 
_pdbx_audit_support.country                Japan 
_pdbx_audit_support.grant_number           JPMJSP2138 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5h59 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 32 2 1' 
_space_group.name_Hall        
;P 32 2"
;
_space_group.IT_number        154 
_space_group.crystal_system   trigonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9L8G 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.016900 
_atom_sites.fract_transf_matrix[1][2]   0.009757 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.019515 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.005371 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
P ? ? 9.51135 5.44231 ? ? 1.42069  35.72801 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N     . SER A 1 1   ? 36.91090  -5.69487  21.01919  1.000 49.72046 ? 1009 SER A N     1 
ATOM   2    C CA    . SER A 1 1   ? 37.57088  -6.96460  21.29852  1.000 38.82869 ? 1009 SER A CA    1 
ATOM   3    C C     . SER A 1 1   ? 36.57286  -8.11109  21.36176  1.000 29.55115 ? 1009 SER A C     1 
ATOM   4    O O     . SER A 1 1   ? 35.48977  -7.98061  21.94035  1.000 29.25454 ? 1009 SER A O     1 
ATOM   5    C CB    . SER A 1 1   ? 38.35974  -6.89203  22.60399  1.000 39.24034 ? 1009 SER A CB    1 
ATOM   6    O OG    . SER A 1 1   ? 39.54345  -6.13394  22.43558  1.000 67.61267 ? 1009 SER A OG    1 
ATOM   7    N N     . LYS A 1 2   ? 36.94759  -9.23243  20.75446  1.000 23.71656 ? 1010 LYS A N     1 
ATOM   8    C CA    . LYS A 1 2   ? 36.08031  -10.40137 20.74282  1.000 16.66472 ? 1010 LYS A CA    1 
ATOM   9    C C     . LYS A 1 2   ? 36.08140  -11.07767 22.11766  1.000 18.00636 ? 1010 LYS A C     1 
ATOM   10   O O     . LYS A 1 2   ? 37.08571  -11.07365 22.84218  1.000 20.75383 ? 1010 LYS A O     1 
ATOM   11   C CB    . LYS A 1 2   ? 36.52786  -11.36423 19.65074  1.000 17.89410 ? 1010 LYS A CB    1 
ATOM   12   C CG    . LYS A 1 2   ? 36.25630  -10.85415 18.21598  1.000 17.84714 ? 1010 LYS A CG    1 
ATOM   13   C CD    . LYS A 1 2   ? 36.77384  -11.84353 17.19402  1.000 16.02473 ? 1010 LYS A CD    1 
ATOM   14   C CE    . LYS A 1 2   ? 36.64730  -11.31697 15.76605  1.000 20.50116 ? 1010 LYS A CE    1 
ATOM   15   N NZ    . LYS A 1 2   ? 35.22825  -11.12553 15.36379  1.000 18.58378 ? 1010 LYS A NZ    1 
ATOM   16   N N     . VAL A 1 3   ? 34.92791  -11.63659 22.48158  1.000 13.77014 ? 1011 VAL A N     1 
ATOM   17   C CA    . VAL A 1 3   ? 34.68129  -12.18813 23.81612  1.000 14.04467 ? 1011 VAL A CA    1 
ATOM   18   C C     . VAL A 1 3   ? 35.26272  -13.59360 23.91102  1.000 12.80416 ? 1011 VAL A C     1 
ATOM   19   O O     . VAL A 1 3   ? 35.00776  -14.44730 23.05304  1.000 13.59163 ? 1011 VAL A O     1 
ATOM   20   C CB    . VAL A 1 3   ? 33.16368  -12.22112 24.08918  1.000 13.92266 ? 1011 VAL A CB    1 
ATOM   21   C CG1   . VAL A 1 3   ? 32.85219  -12.92411 25.41399  1.000 15.58291 ? 1011 VAL A CG1   1 
ATOM   22   C CG2   . VAL A 1 3   ? 32.57709  -10.81114 24.04131  1.000 17.40533 ? 1011 VAL A CG2   1 
ATOM   23   N N     . SER A 1 4   ? 36.01649  -13.86817 24.98292  1.000 13.38828 ? 1012 SER A N     1 
ATOM   24   C CA    A SER A 1 4   ? 36.56302  -15.20544 25.17412  0.766 12.77925 ? 1012 SER A CA    1 
ATOM   25   C CA    B SER A 1 4   ? 36.56482  -15.20528 25.17775  0.234 12.82669 ? 1012 SER A CA    1 
ATOM   26   C C     . SER A 1 4   ? 35.44139  -16.22098 25.37798  1.000 12.65948 ? 1012 SER A C     1 
ATOM   27   O O     . SER A 1 4   ? 34.48814  -15.97481 26.12640  1.000 14.90919 ? 1012 SER A O     1 
ATOM   28   C CB    A SER A 1 4   ? 37.48289  -15.21164 26.39865  0.766 16.21628 ? 1012 SER A CB    1 
ATOM   29   C CB    B SER A 1 4   ? 37.48983  -15.20801 26.39890  0.234 16.22124 ? 1012 SER A CB    1 
ATOM   30   O OG    A SER A 1 4   ? 38.61565  -14.39303 26.17091  0.766 19.14034 ? 1012 SER A OG    1 
ATOM   31   O OG    B SER A 1 4   ? 37.85992  -16.52565 26.76840  0.234 16.08042 ? 1012 SER A OG    1 
ATOM   32   N N     . VAL A 1 5   ? 35.56681  -17.37679 24.70983  1.000 11.46245 ? 1013 VAL A N     1 
ATOM   33   C CA    . VAL A 1 5   ? 34.60092  -18.47299 24.81324  1.000 11.99063 ? 1013 VAL A CA    1 
ATOM   34   C C     . VAL A 1 5   ? 35.31937  -19.75006 25.23500  1.000 13.49977 ? 1013 VAL A C     1 
ATOM   35   O O     . VAL A 1 5   ? 36.51318  -19.94294 24.97128  1.000 12.90166 ? 1013 VAL A O     1 
ATOM   36   C CB    . VAL A 1 5   ? 33.81633  -18.70068 23.49533  1.000 12.13822 ? 1013 VAL A CB    1 
ATOM   37   C CG1   . VAL A 1 5   ? 32.86798  -17.54401 23.21192  1.000 13.45279 ? 1013 VAL A CG1   1 
ATOM   38   C CG2   . VAL A 1 5   ? 34.78475  -18.91547 22.34247  1.000 13.16688 ? 1013 VAL A CG2   1 
ATOM   39   N N     . ALA A 1 6   ? 34.58059  -20.63535 25.89468  1.000 12.33562 ? 1014 ALA A N     1 
ATOM   40   C CA    . ALA A 1 6   ? 35.10475  -21.92434 26.31760  1.000 10.83145 ? 1014 ALA A CA    1 
ATOM   41   C C     . ALA A 1 6   ? 33.95316  -22.91277 26.30575  1.000 10.92470 ? 1014 ALA A C     1 
ATOM   42   O O     . ALA A 1 6   ? 32.79394  -22.51114 26.46899  1.000 12.05719 ? 1014 ALA A O     1 
ATOM   43   C CB    . ALA A 1 6   ? 35.71041  -21.84309 27.72557  1.000 11.78559 ? 1014 ALA A CB    1 
ATOM   44   N N     . PRO A 1 7   ? 34.23358  -24.22533 26.14659  1.000 10.79698 ? 1015 PRO A N     1 
ATOM   45   C CA    . PRO A 1 7   ? 35.54939  -24.83501 25.91233  1.000 10.49112 ? 1015 PRO A CA    1 
ATOM   46   C C     . PRO A 1 7   ? 35.86989  -24.97397 24.42595  1.000 12.15052 ? 1015 PRO A C     1 
ATOM   47   O O     . PRO A 1 7   ? 34.97678  -25.28309 23.61806  1.000 12.30223 ? 1015 PRO A O     1 
ATOM   48   C CB    . PRO A 1 7   ? 35.41303  -26.22278 26.56253  1.000 11.04674 ? 1015 PRO A CB    1 
ATOM   49   C CG    . PRO A 1 7   ? 33.93418  -26.57495 26.31445  1.000 12.64991 ? 1015 PRO A CG    1 
ATOM   50   C CD    . PRO A 1 7   ? 33.18804  -25.25496 26.34018  1.000 12.11861 ? 1015 PRO A CD    1 
ATOM   51   N N     . LEU A 1 8   ? 37.15025  -24.80402 24.07504  1.000 10.95896 ? 1016 LEU A N     1 
ATOM   52   C CA    . LEU A 1 8   ? 37.56917  -24.88849 22.67216  1.000 11.71001 ? 1016 LEU A CA    1 
ATOM   53   C C     . LEU A 1 8   ? 37.28400  -26.25434 22.05188  1.000 11.28479 ? 1016 LEU A C     1 
ATOM   54   O O     . LEU A 1 8   ? 37.18196  -26.35501 20.82059  1.000 11.92863 ? 1016 LEU A O     1 
ATOM   55   C CB    . LEU A 1 8   ? 39.05902  -24.54664 22.54439  1.000 15.31379 ? 1016 LEU A CB    1 
ATOM   56   C CG    . LEU A 1 8   ? 39.38733  -23.07700 22.79605  1.000 21.34493 ? 1016 LEU A CG    1 
ATOM   57   C CD1   . LEU A 1 8   ? 40.88077  -22.81547 22.63102  1.000 29.00224 ? 1016 LEU A CD1   1 
ATOM   58   C CD2   . LEU A 1 8   ? 38.57816  -22.19669 21.85687  1.000 25.32381 ? 1016 LEU A CD2   1 
ATOM   59   N N     . HIS A 1 9   ? 37.14017  -27.31118 22.85846  1.000 11.10927 ? 1017 HIS A N     1 
ATOM   60   C CA    . HIS A 1 9   ? 36.83396  -28.62341 22.29381  1.000 10.45992 ? 1017 HIS A CA    1 
ATOM   61   C C     . HIS A 1 9   ? 35.50112  -28.66119 21.55052  1.000 12.24356 ? 1017 HIS A C     1 
ATOM   62   O O     . HIS A 1 9   ? 35.25634  -29.61532 20.80170  1.000 13.66814 ? 1017 HIS A O     1 
ATOM   63   C CB    . HIS A 1 9   ? 36.96867  -29.77239 23.33108  1.000 12.17828 ? 1017 HIS A CB    1 
ATOM   64   C CG    . HIS A 1 9   ? 35.90559  -29.80921 24.39559  1.000 12.63714 ? 1017 HIS A CG    1 
ATOM   65   N ND1   . HIS A 1 9   ? 36.18163  -29.58518 25.72834  1.000 12.39720 ? 1017 HIS A ND1   1 
ATOM   66   C CD2   . HIS A 1 9   ? 34.58719  -30.12910 24.33779  1.000 13.36478 ? 1017 HIS A CD2   1 
ATOM   67   C CE1   . HIS A 1 9   ? 35.07794  -29.73355 26.44043  1.000 14.38270 ? 1017 HIS A CE1   1 
ATOM   68   N NE2   . HIS A 1 9   ? 34.09648  -30.07238 25.62089  1.000 14.39664 ? 1017 HIS A NE2   1 
ATOM   69   N N     . LEU A 1 10  ? 34.64492  -27.64841 21.72184  1.000 11.87434 ? 1018 LEU A N     1 
ATOM   70   C CA    . LEU A 1 10  ? 33.43029  -27.59761 20.90826  1.000 13.20877 ? 1018 LEU A CA    1 
ATOM   71   C C     . LEU A 1 10  ? 33.73769  -27.41138 19.43170  1.000 13.41686 ? 1018 LEU A C     1 
ATOM   72   O O     . LEU A 1 10  ? 32.85622  -27.67173 18.59969  1.000 13.87913 ? 1018 LEU A O     1 
ATOM   73   C CB    . LEU A 1 10  ? 32.49952  -26.49404 21.39626  1.000 11.60093 ? 1018 LEU A CB    1 
ATOM   74   C CG    . LEU A 1 10  ? 31.95294  -26.69228 22.81080  1.000 13.24609 ? 1018 LEU A CG    1 
ATOM   75   C CD1   . LEU A 1 10  ? 30.90662  -25.62621 23.11523  1.000 15.47892 ? 1018 LEU A CD1   1 
ATOM   76   C CD2   . LEU A 1 10  ? 31.39538  -28.10863 22.99612  1.000 15.96961 ? 1018 LEU A CD2   1 
ATOM   77   N N     . GLU A 1 11  ? 34.96055  -26.98892 19.07553  1.000 12.20046 ? 1019 GLU A N     1 
ATOM   78   C CA    . GLU A 1 11  ? 35.35008  -26.85472 17.67630  1.000 11.73024 ? 1019 GLU A CA    1 
ATOM   79   C C     . GLU A 1 11  ? 35.88643  -28.14972 17.07434  1.000 13.18083 ? 1019 GLU A C     1 
ATOM   80   O O     . GLU A 1 11  ? 36.14144  -28.18433 15.86603  1.000 15.59482 ? 1019 GLU A O     1 
ATOM   81   C CB    . GLU A 1 11  ? 36.40824  -25.75298 17.51063  1.000 11.89676 ? 1019 GLU A CB    1 
ATOM   82   C CG    . GLU A 1 11  ? 35.98443  -24.40102 18.02917  1.000 12.53494 ? 1019 GLU A CG    1 
ATOM   83   C CD    . GLU A 1 11  ? 34.87299  -23.77817 17.21655  1.000 11.61581 ? 1019 GLU A CD    1 
ATOM   84   O OE1   . GLU A 1 11  ? 34.84654  -24.00116 15.99169  1.000 14.40023 ? 1019 GLU A OE1   1 
ATOM   85   O OE2   . GLU A 1 11  ? 34.02004  -23.09087 17.81328  1.000 11.72880 ? 1019 GLU A OE2   1 
ATOM   86   N N     . SER A 1 12  ? 36.06477  -29.21011 17.87788  1.000 14.08121 ? 1020 SER A N     1 
ATOM   87   C CA    . SER A 1 12  ? 36.80180  -30.39138 17.41817  1.000 15.68739 ? 1020 SER A CA    1 
ATOM   88   C C     . SER A 1 12  ? 35.97242  -31.31806 16.53656  1.000 20.10442 ? 1020 SER A C     1 
ATOM   89   O O     . SER A 1 12  ? 36.52442  -31.93887 15.61743  1.000 22.51065 ? 1020 SER A O     1 
ATOM   90   C CB    . SER A 1 12  ? 37.35388  -31.18659 18.60370  1.000 17.22774 ? 1020 SER A CB    1 
ATOM   91   O OG    . SER A 1 12  ? 38.26822  -30.39703 19.34115  1.000 20.58116 ? 1020 SER A OG    1 
ATOM   92   N N     . ALA A 1 13  ? 34.67411  -31.43934 16.80422  1.000 19.28028 ? 1021 ALA A N     1 
ATOM   93   C CA    . ALA A 1 13  ? 33.83190  -32.35301 16.03695  1.000 22.44205 ? 1021 ALA A CA    1 
ATOM   94   C C     . ALA A 1 13  ? 33.78671  -31.95027 14.56499  1.000 17.80750 ? 1021 ALA A C     1 
ATOM   95   O O     . ALA A 1 13  ? 33.75136  -30.76974 14.22077  1.000 19.40017 ? 1021 ALA A O     1 
ATOM   96   C CB    . ALA A 1 13  ? 32.41646  -32.37356 16.62074  1.000 23.18361 ? 1021 ALA A CB    1 
ATOM   97   N N     . LYS A 1 14  ? 33.81016  -32.94553 13.68505  1.000 21.96111 ? 1022 LYS A N     1 
ATOM   98   C CA    . LYS A 1 14  ? 33.76158  -32.66955 12.26024  1.000 23.63816 ? 1022 LYS A CA    1 
ATOM   99   C C     . LYS A 1 14  ? 32.37090  -32.85020 11.66576  1.000 21.82085 ? 1022 LYS A C     1 
ATOM   100  O O     . LYS A 1 14  ? 32.15756  -32.48593 10.50550  1.000 25.14934 ? 1022 LYS A O     1 
ATOM   101  C CB    . LYS A 1 14  ? 34.79430  -33.52894 11.51795  1.000 34.68216 ? 1022 LYS A CB    1 
ATOM   102  C CG    . LYS A 1 14  ? 36.23372  -33.07552 11.76493  1.000 33.53404 ? 1022 LYS A CG    1 
ATOM   103  C CD    . LYS A 1 14  ? 36.30630  -31.55745 11.93046  1.000 39.91609 ? 1022 LYS A CD    1 
ATOM   104  C CE    . LYS A 1 14  ? 37.68705  -31.08712 12.37197  1.000 53.77726 ? 1022 LYS A CE    1 
ATOM   105  N NZ    . LYS A 1 14  ? 37.60257  -29.87921 13.24906  1.000 40.90987 ? 1022 LYS A NZ    1 
ATOM   106  N N     . GLU A 1 15  ? 31.42876  -33.38386 12.43395  1.000 20.28217 ? 1023 GLU A N     1 
ATOM   107  C CA    . GLU A 1 15  ? 30.04110  -33.55476 12.04155  1.000 25.95830 ? 1023 GLU A CA    1 
ATOM   108  C C     . GLU A 1 15  ? 29.15163  -32.95441 13.11955  1.000 19.97836 ? 1023 GLU A C     1 
ATOM   109  O O     . GLU A 1 15  ? 29.51616  -32.94722 14.30420  1.000 18.09011 ? 1023 GLU A O     1 
ATOM   110  C CB    . GLU A 1 15  ? 29.71143  -35.04679 11.90774  1.000 24.49126 ? 1023 GLU A CB    1 
ATOM   111  C CG    . GLU A 1 15  ? 30.35857  -35.71680 10.71540  1.000 37.40110 ? 1023 GLU A CG    1 
ATOM   112  C CD    . GLU A 1 15  ? 30.21815  -37.22422 10.76074  1.000 64.67741 ? 1023 GLU A CD    1 
ATOM   113  O OE1   . GLU A 1 15  ? 30.31138  -37.86251 9.69125   1.000 73.66124 ? 1023 GLU A OE1   1 
ATOM   114  O OE2   . GLU A 1 15  ? 30.01798  -37.76973 11.86826  1.000 74.06158 ? 1023 GLU A OE2   1 
ATOM   115  N N     . PRO A 1 16  ? 27.98266  -32.42983 12.74199  1.000 16.86190 ? 1024 PRO A N     1 
ATOM   116  C CA    . PRO A 1 16  ? 27.10891  -31.82372 13.74345  1.000 17.37420 ? 1024 PRO A CA    1 
ATOM   117  C C     . PRO A 1 16  ? 26.44118  -32.89562 14.58450  1.000 16.89494 ? 1024 PRO A C     1 
ATOM   118  O O     . PRO A 1 16  ? 26.16796  -34.00875 14.09843  1.000 18.37375 ? 1024 PRO A O     1 
ATOM   119  C CB    . PRO A 1 16  ? 26.07791  -31.06121 12.89093  1.000 22.26296 ? 1024 PRO A CB    1 
ATOM   120  C CG    . PRO A 1 16  ? 26.00206  -31.85339 11.65518  1.000 21.01930 ? 1024 PRO A CG    1 
ATOM   121  C CD    . PRO A 1 16  ? 27.43369  -32.28011 11.37991  1.000 20.76666 ? 1024 PRO A CD    1 
ATOM   122  N N     . PRO A 1 17  ? 26.17842  -32.61623 15.86131  1.000 16.39439 ? 1025 PRO A N     1 
ATOM   123  C CA    . PRO A 1 17  ? 25.40058  -33.55305 16.67653  1.000 16.22809 ? 1025 PRO A CA    1 
ATOM   124  C C     . PRO A 1 17  ? 23.99513  -33.66359 16.10445  1.000 14.43884 ? 1025 PRO A C     1 
ATOM   125  O O     . PRO A 1 17  ? 23.40846  -32.67515 15.66312  1.000 15.80246 ? 1025 PRO A O     1 
ATOM   126  C CB    . PRO A 1 17  ? 25.36799  -32.86894 18.05079  1.000 18.58281 ? 1025 PRO A CB    1 
ATOM   127  C CG    . PRO A 1 17  ? 26.50315  -31.88851 18.02947  1.000 24.81111 ? 1025 PRO A CG    1 
ATOM   128  C CD    . PRO A 1 17  ? 26.53141  -31.40342 16.61514  1.000 18.76886 ? 1025 PRO A CD    1 
ATOM   129  N N     . LEU A 1 18  ? 23.44247  -34.87293 16.11567  1.000 14.85269 ? 1026 LEU A N     1 
ATOM   130  C CA    . LEU A 1 18  ? 22.06458  -35.06801 15.66944  1.000 13.78098 ? 1026 LEU A CA    1 
ATOM   131  C C     . LEU A 1 18  ? 21.38546  -36.10641 16.54452  1.000 14.36687 ? 1026 LEU A C     1 
ATOM   132  O O     . LEU A 1 18  ? 21.90303  -37.21756 16.70863  1.000 15.12070 ? 1026 LEU A O     1 
ATOM   133  C CB    . LEU A 1 18  ? 21.97745  -35.53028 14.20197  1.000 17.98560 ? 1026 LEU A CB    1 
ATOM   134  C CG    . LEU A 1 18  ? 22.35757  -34.53825 13.10578  1.000 19.95086 ? 1026 LEU A CG    1 
ATOM   135  C CD1   . LEU A 1 18  ? 22.37940  -35.25335 11.76333  1.000 22.43451 ? 1026 LEU A CD1   1 
ATOM   136  C CD2   . LEU A 1 18  ? 21.40864  -33.35333 13.08652  1.000 18.98401 ? 1026 LEU A CD2   1 
ATOM   137  N N     . ASN A 1 19  ? 20.21967  -35.74812 17.09164  1.000 13.61802 ? 1027 ASN A N     1 
ATOM   138  C CA    . ASN A 1 19  ? 19.36654  -36.70669 17.80422  1.000 14.09972 ? 1027 ASN A CA    1 
ATOM   139  C C     . ASN A 1 19  ? 20.07851  -37.33553 18.99079  1.000 16.09842 ? 1027 ASN A C     1 
ATOM   140  O O     . ASN A 1 19  ? 19.88426  -38.51302 19.30507  1.000 16.16228 ? 1027 ASN A O     1 
ATOM   141  C CB    . ASN A 1 19  ? 18.80059  -37.77242 16.87214  1.000 17.05238 ? 1027 ASN A CB    1 
ATOM   142  C CG    . ASN A 1 19  ? 17.95681  -37.17877 15.80052  1.000 17.04372 ? 1027 ASN A CG    1 
ATOM   143  O OD1   . ASN A 1 19  ? 16.94139  -36.54279 16.08358  1.000 20.09817 ? 1027 ASN A OD1   1 
ATOM   144  N ND2   . ASN A 1 19  ? 18.38541  -37.33669 14.56224  1.000 18.69523 ? 1027 ASN A ND2   1 
ATOM   145  N N     . THR A 1 20  ? 20.89839  -36.52767 19.66538  1.000 13.44839 ? 1028 THR A N     1 
ATOM   146  C CA    . THR A 1 20  ? 21.59492  -36.98758 20.85483  1.000 13.62851 ? 1028 THR A CA    1 
ATOM   147  C C     . THR A 1 20  ? 20.60244  -37.46649 21.90362  1.000 14.37862 ? 1028 THR A C     1 
ATOM   148  O O     . THR A 1 20  ? 20.83148  -38.48862 22.56525  1.000 16.43746 ? 1028 THR A O     1 
ATOM   149  C CB    . THR A 1 20  ? 22.43494  -35.83046 21.38963  1.000 13.47997 ? 1028 THR A CB    1 
ATOM   150  O OG1   . THR A 1 20  ? 23.20358  -35.28883 20.30171  1.000 13.24512 ? 1028 THR A OG1   1 
ATOM   151  C CG2   . THR A 1 20  ? 23.36472  -36.29509 22.49744  1.000 14.16587 ? 1028 THR A CG2   1 
ATOM   152  N N     . TYR A 1 21  ? 19.49865  -36.73669 22.06781  1.000 12.90531 ? 1029 TYR A N     1 
ATOM   153  C CA    . TYR A 1 21  ? 18.38032  -37.14256 22.91479  1.000 13.27049 ? 1029 TYR A CA    1 
ATOM   154  C C     . TYR A 1 21  ? 17.12739  -37.29854 22.06794  1.000 12.68297 ? 1029 TYR A C     1 
ATOM   155  O O     . TYR A 1 21  ? 16.87863  -36.50350 21.15166  1.000 14.22076 ? 1029 TYR A O     1 
ATOM   156  C CB    . TYR A 1 21  ? 18.13846  -36.13166 24.05228  1.000 13.00108 ? 1029 TYR A CB    1 
ATOM   157  C CG    . TYR A 1 21  ? 19.23271  -36.23284 25.09063  1.000 13.96963 ? 1029 TYR A CG    1 
ATOM   158  C CD1   . TYR A 1 21  ? 20.43246  -35.54289 24.92674  1.000 14.32928 ? 1029 TYR A CD1   1 
ATOM   159  C CD2   . TYR A 1 21  ? 19.08350  -37.05174 26.21095  1.000 13.88390 ? 1029 TYR A CD2   1 
ATOM   160  C CE1   . TYR A 1 21  ? 21.45902  -35.65805 25.86309  1.000 15.64664 ? 1029 TYR A CE1   1 
ATOM   161  C CE2   . TYR A 1 21  ? 20.10834  -37.17884 27.14504  1.000 15.57007 ? 1029 TYR A CE2   1 
ATOM   162  C CZ    . TYR A 1 21  ? 21.28802  -36.47784 26.96023  1.000 16.11998 ? 1029 TYR A CZ    1 
ATOM   163  O OH    . TYR A 1 21  ? 22.30047  -36.58568 27.89799  1.000 19.28620 ? 1029 TYR A OH    1 
ATOM   164  N N     . LYS A 1 22  ? 16.33335  -38.31672 22.39175  1.000 15.04696 ? 1030 LYS A N     1 
ATOM   165  C CA    . LYS A 1 22  ? 15.16016  -38.71670 21.62855  1.000 16.22359 ? 1030 LYS A CA    1 
ATOM   166  C C     . LYS A 1 22  ? 13.90980  -38.59586 22.49244  1.000 15.30090 ? 1030 LYS A C     1 
ATOM   167  O O     . LYS A 1 22  ? 14.00308  -38.52193 23.72305  1.000 16.62221 ? 1030 LYS A O     1 
ATOM   168  C CB    . LYS A 1 22  ? 15.32249  -40.16589 21.14675  1.000 18.50388 ? 1030 LYS A CB    1 
ATOM   169  C CG    . LYS A 1 22  ? 16.45388  -40.34790 20.12816  1.000 21.56395 ? 1030 LYS A CG    1 
ATOM   170  C CD    . LYS A 1 22  ? 16.69754  -41.82071 19.80660  1.000 21.94712 ? 1030 LYS A CD    1 
ATOM   171  C CE    . LYS A 1 22  ? 18.12642  -42.09726 19.35409  1.000 29.02154 ? 1030 LYS A CE    1 
ATOM   172  N NZ    . LYS A 1 22  ? 18.67099  -41.08105 18.40486  1.000 38.22600 ? 1030 LYS A NZ    1 
ATOM   173  N N     . PRO A 1 23  ? 12.71813  -38.57401 21.87999  1.000 14.57756 ? 1031 PRO A N     1 
ATOM   174  C CA    . PRO A 1 23  ? 11.50171  -38.25551 22.65405  1.000 18.86154 ? 1031 PRO A CA    1 
ATOM   175  C C     . PRO A 1 23  ? 11.17996  -39.21220 23.79543  1.000 19.10825 ? 1031 PRO A C     1 
ATOM   176  O O     . PRO A 1 23  ? 10.62597  -38.76948 24.80803  1.000 23.91947 ? 1031 PRO A O     1 
ATOM   177  C CB    . PRO A 1 23  ? 10.40537  -38.26395 21.57803  1.000 26.08172 ? 1031 PRO A CB    1 
ATOM   178  C CG    . PRO A 1 23  ? 11.12520  -37.81373 20.36137  1.000 22.53958 ? 1031 PRO A CG    1 
ATOM   179  C CD    . PRO A 1 23  ? 12.43239  -38.57510 20.43255  1.000 19.62773 ? 1031 PRO A CD    1 
ATOM   180  N N     . LYS A 1 24  ? 11.49900  -40.49990 23.67911  1.000 18.49083 ? 1032 LYS A N     1 
ATOM   181  C CA    . LYS A 1 24  ? 11.19064  -41.41398 24.77645  1.000 20.82785 ? 1032 LYS A CA    1 
ATOM   182  C C     . LYS A 1 24  ? 12.02287  -41.11705 26.01557  1.000 22.63870 ? 1032 LYS A C     1 
ATOM   183  O O     . LYS A 1 24  ? 11.59320  -41.42530 27.13042  1.000 25.77288 ? 1032 LYS A O     1 
ATOM   184  C CB    . LYS A 1 24  ? 11.37967  -42.87500 24.36223  1.000 27.29030 ? 1032 LYS A CB    1 
ATOM   185  C CG    . LYS A 1 24  ? 10.68435  -43.28354 23.06917  1.000 43.98410 ? 1032 LYS A CG    1 
ATOM   186  C CD    . LYS A 1 24  ? 9.22618   -42.87494 23.01723  1.000 39.95172 ? 1032 LYS A CD    1 
ATOM   187  C CE    . LYS A 1 24  ? 8.37180   -44.03121 22.52456  1.000 48.32964 ? 1032 LYS A CE    1 
ATOM   188  N NZ    . LYS A 1 24  ? 8.61062   -45.27171 23.31478  1.000 55.69689 ? 1032 LYS A NZ    1 
ATOM   189  N N     . GLU A 1 25  ? 13.22182  -40.55144 25.84789  1.000 18.87291 ? 1033 GLU A N     1 
ATOM   190  C CA    . GLU A 1 25  ? 14.12299  -40.25532 26.96600  1.000 18.54254 ? 1033 GLU A CA    1 
ATOM   191  C C     . GLU A 1 25  ? 14.79248  -38.90892 26.72804  1.000 15.10362 ? 1033 GLU A C     1 
ATOM   192  O O     . GLU A 1 25  ? 15.98185  -38.83324 26.39588  1.000 16.31860 ? 1033 GLU A O     1 
ATOM   193  C CB    . GLU A 1 25  ? 15.15967  -41.36390 27.15871  1.000 22.12042 ? 1033 GLU A CB    1 
ATOM   194  C CG    . GLU A 1 25  ? 14.64456  -42.78212 26.93032  1.000 34.83732 ? 1033 GLU A CG    1 
ATOM   195  C CD    . GLU A 1 25  ? 15.66362  -43.83681 27.31199  1.000 48.74885 ? 1033 GLU A CD    1 
ATOM   196  O OE1   . GLU A 1 25  ? 15.54051  -44.41644 28.41130  1.000 53.25703 ? 1033 GLU A OE1   1 
ATOM   197  O OE2   . GLU A 1 25  ? 16.58113  -44.09362 26.50285  1.000 53.28765 ? 1033 GLU A OE2   1 
ATOM   198  N N     . PRO A 1 26  ? 14.05259  -37.82047 26.89780  1.000 15.38197 ? 1034 PRO A N     1 
ATOM   199  C CA    . PRO A 1 26  ? 14.62295  -36.49145 26.66009  1.000 13.33284 ? 1034 PRO A CA    1 
ATOM   200  C C     . PRO A 1 26  ? 15.63543  -36.13848 27.73578  1.000 12.83133 ? 1034 PRO A C     1 
ATOM   201  O O     . PRO A 1 26  ? 15.74635  -36.79103 28.78266  1.000 16.09478 ? 1034 PRO A O     1 
ATOM   202  C CB    . PRO A 1 26  ? 13.42297  -35.54375 26.72827  1.000 15.40652 ? 1034 PRO A CB    1 
ATOM   203  C CG    . PRO A 1 26  ? 12.20078  -36.43185 26.77648  1.000 21.95772 ? 1034 PRO A CG    1 
ATOM   204  C CD    . PRO A 1 26  ? 12.64222  -37.75379 27.30741  1.000 16.32074 ? 1034 PRO A CD    1 
ATOM   205  N N     . PHE A 1 27  ? 16.38510  -35.07122 27.47226  1.000 12.27511 ? 1035 PHE A N     1 
ATOM   206  C CA    . PHE A 1 27  ? 17.26199  -34.50555 28.49251  1.000 11.82708 ? 1035 PHE A CA    1 
ATOM   207  C C     . PHE A 1 27  ? 16.46920  -33.50035 29.32389  1.000 12.94076 ? 1035 PHE A C     1 
ATOM   208  O O     . PHE A 1 27  ? 15.83012  -32.60285 28.77122  1.000 13.14190 ? 1035 PHE A O     1 
ATOM   209  C CB    . PHE A 1 27  ? 18.48541  -33.82065 27.86286  1.000 12.33529 ? 1035 PHE A CB    1 
ATOM   210  C CG    . PHE A 1 27  ? 19.39268  -33.20748 28.88984  1.000 11.88310 ? 1035 PHE A CG    1 
ATOM   211  C CD1   . PHE A 1 27  ? 20.29944  -33.99819 29.58179  1.000 13.19118 ? 1035 PHE A CD1   1 
ATOM   212  C CD2   . PHE A 1 27  ? 19.29667  -31.86454 29.22134  1.000 11.72517 ? 1035 PHE A CD2   1 
ATOM   213  C CE1   . PHE A 1 27  ? 21.11346  -33.43867 30.57949  1.000 12.85617 ? 1035 PHE A CE1   1 
ATOM   214  C CE2   . PHE A 1 27  ? 20.09584  -31.29878 30.21627  1.000 10.94088 ? 1035 PHE A CE2   1 
ATOM   215  C CZ    . PHE A 1 27  ? 21.00815  -32.09308 30.88885  1.000 13.90290 ? 1035 PHE A CZ    1 
ATOM   216  N N     . THR A 1 28  ? 16.51480  -33.63507 30.65176  1.000 10.97194 ? 1036 THR A N     1 
ATOM   217  C CA    . THR A 1 28  ? 15.79104  -32.71363 31.52750  1.000 11.45638 ? 1036 THR A CA    1 
ATOM   218  C C     . THR A 1 28  ? 16.67419  -31.50107 31.80452  1.000 10.77118 ? 1036 THR A C     1 
ATOM   219  O O     . THR A 1 28  ? 17.52137  -31.50169 32.70727  1.000 12.62837 ? 1036 THR A O     1 
ATOM   220  C CB    . THR A 1 28  ? 15.35846  -33.40095 32.81929  1.000 12.66530 ? 1036 THR A CB    1 
ATOM   221  O OG1   . THR A 1 28  ? 14.58086  -34.56456 32.51417  1.000 16.60086 ? 1036 THR A OG1   1 
ATOM   222  C CG2   . THR A 1 28  ? 14.52996  -32.45758 33.68445  1.000 13.77384 ? 1036 THR A CG2   1 
ATOM   223  N N     . ALA A 1 29  ? 16.51267  -30.47138 30.97576  1.000 11.41356 ? 1037 ALA A N     1 
ATOM   224  C CA    . ALA A 1 29  ? 17.22930  -29.21023 31.10789  1.000 10.39659 ? 1037 ALA A CA    1 
ATOM   225  C C     . ALA A 1 29  ? 16.50781  -28.28161 32.08910  1.000 10.41777 ? 1037 ALA A C     1 
ATOM   226  O O     . ALA A 1 29  ? 15.39274  -28.56356 32.54434  1.000 11.06378 ? 1037 ALA A O     1 
ATOM   227  C CB    . ALA A 1 29  ? 17.35321  -28.54636 29.73487  1.000 12.44809 ? 1037 ALA A CB    1 
ATOM   228  N N     . THR A 1 30  ? 17.12714  -27.13493 32.40011  1.000 10.38482 ? 1038 THR A N     1 
ATOM   229  C CA    . THR A 1 30  ? 16.60314  -26.21729 33.41243  1.000 9.56664  ? 1038 THR A CA    1 
ATOM   230  C C     . THR A 1 30  ? 16.61052  -24.78046 32.89426  1.000 12.06023 ? 1038 THR A C     1 
ATOM   231  O O     . THR A 1 30  ? 17.62059  -24.31112 32.35743  1.000 11.95272 ? 1038 THR A O     1 
ATOM   232  C CB    . THR A 1 30  ? 17.41872  -26.34776 34.70715  1.000 10.06635 ? 1038 THR A CB    1 
ATOM   233  O OG1   . THR A 1 30  ? 17.37523  -27.71356 35.13178  1.000 11.02028 ? 1038 THR A OG1   1 
ATOM   234  C CG2   . THR A 1 30  ? 16.85354  -25.45145 35.80661  1.000 12.05878 ? 1038 THR A CG2   1 
ATOM   235  N N     . ILE A 1 31  ? 15.48475  -24.08186 33.05485  1.000 11.07746 ? 1039 ILE A N     1 
ATOM   236  C CA    . ILE A 1 31  ? 15.39339  -22.67354 32.66202  1.000 11.22776 ? 1039 ILE A CA    1 
ATOM   237  C C     . ILE A 1 31  ? 16.32457  -21.81170 33.50314  1.000 10.98623 ? 1039 ILE A C     1 
ATOM   238  O O     . ILE A 1 31  ? 16.30703  -21.87426 34.74158  1.000 11.77548 ? 1039 ILE A O     1 
ATOM   239  C CB    . ILE A 1 31  ? 13.94278  -22.18742 32.81354  1.000 11.69354 ? 1039 ILE A CB    1 
ATOM   240  C CG1   . ILE A 1 31  ? 13.03275  -22.92714 31.83782  1.000 12.24575 ? 1039 ILE A CG1   1 
ATOM   241  C CG2   . ILE A 1 31  ? 13.83305  -20.67241 32.62376  1.000 14.23057 ? 1039 ILE A CG2   1 
ATOM   242  C CD1   . ILE A 1 31  ? 13.13281  -22.37786 30.41796  1.000 13.16427 ? 1039 ILE A CD1   1 
ATOM   243  N N     . VAL A 1 32  ? 17.10107  -20.96369 32.83020  1.000 12.06160 ? 1040 VAL A N     1 
ATOM   244  C CA    . VAL A 1 32  ? 17.90376  -19.92774 33.48438  1.000 12.37951 ? 1040 VAL A CA    1 
ATOM   245  C C     . VAL A 1 32  ? 17.13555  -18.61419 33.57305  1.000 14.42973 ? 1040 VAL A C     1 
ATOM   246  O O     . VAL A 1 32  ? 17.07377  -17.98050 34.63225  1.000 13.62157 ? 1040 VAL A O     1 
ATOM   247  C CB    . VAL A 1 32  ? 19.23377  -19.74001 32.71367  1.000 12.89230 ? 1040 VAL A CB    1 
ATOM   248  C CG1   . VAL A 1 32  ? 20.02581  -18.57987 33.31391  1.000 16.74994 ? 1040 VAL A CG1   1 
ATOM   249  C CG2   . VAL A 1 32  ? 20.05109  -21.01591 32.70476  1.000 12.37970 ? 1040 VAL A CG2   1 
ATOM   250  N N     . SER A 1 33  ? 16.54255  -18.18232 32.45739  1.000 13.16559 ? 1041 SER A N     1 
ATOM   251  C CA    . SER A 1 33  ? 15.83366  -16.90840 32.39952  1.000 13.34538 ? 1041 SER A CA    1 
ATOM   252  C C     . SER A 1 33  ? 14.82786  -16.90834 31.25047  1.000 12.29041 ? 1041 SER A C     1 
ATOM   253  O O     . SER A 1 33  ? 14.99477  -17.61508 30.25102  1.000 11.85294 ? 1041 SER A O     1 
ATOM   254  C CB    . SER A 1 33  ? 16.79799  -15.72997 32.23505  1.000 15.84211 ? 1041 SER A CB    1 
ATOM   255  O OG    . SER A 1 33  ? 17.53941  -15.85862 31.02561  1.000 14.34024 ? 1041 SER A OG    1 
ATOM   256  N N     . VAL A 1 34  ? 13.77942  -16.10491 31.42000  1.000 12.42931 ? 1042 VAL A N     1 
ATOM   257  C CA    . VAL A 1 34  ? 12.78901  -15.81258 30.38293  1.000 11.61544 ? 1042 VAL A CA    1 
ATOM   258  C C     . VAL A 1 34  ? 12.54682  -14.31150 30.41958  1.000 13.58760 ? 1042 VAL A C     1 
ATOM   259  O O     . VAL A 1 34  ? 12.22178  -13.76351 31.47861  1.000 16.47942 ? 1042 VAL A O     1 
ATOM   260  C CB    . VAL A 1 34  ? 11.46444  -16.56561 30.63532  1.000 13.46793 ? 1042 VAL A CB    1 
ATOM   261  C CG1   . VAL A 1 34  ? 10.39704  -16.14677 29.61423  1.000 17.12689 ? 1042 VAL A CG1   1 
ATOM   262  C CG2   . VAL A 1 34  ? 11.70043  -18.05336 30.56834  1.000 15.09880 ? 1042 VAL A CG2   1 
ATOM   263  N N     . GLU A 1 35  ? 12.69693  -13.63442 29.27771  1.000 13.68683 ? 1043 GLU A N     1 
ATOM   264  C CA    A GLU A 1 35  ? 12.51099  -12.19078 29.22284  0.540 14.24313 ? 1043 GLU A CA    1 
ATOM   265  C CA    B GLU A 1 35  ? 12.54165  -12.18561 29.20935  0.460 14.25923 ? 1043 GLU A CA    1 
ATOM   266  C C     . GLU A 1 35  ? 11.82514  -11.79984 27.92232  1.000 14.31262 ? 1043 GLU A C     1 
ATOM   267  O O     . GLU A 1 35  ? 12.10288  -12.36414 26.86074  1.000 15.47665 ? 1043 GLU A O     1 
ATOM   268  C CB    A GLU A 1 35  ? 13.84608  -11.43468 29.34109  0.540 16.33367 ? 1043 GLU A CB    1 
ATOM   269  C CB    B GLU A 1 35  ? 13.91184  -11.48268 29.23753  0.460 16.23430 ? 1043 GLU A CB    1 
ATOM   270  C CG    A GLU A 1 35  ? 14.64812  -11.71302 30.61807  0.540 17.02694 ? 1043 GLU A CG    1 
ATOM   271  C CG    B GLU A 1 35  ? 14.77277  -11.73596 28.00303  0.460 20.08961 ? 1043 GLU A CG    1 
ATOM   272  C CD    A GLU A 1 35  ? 13.96287  -11.20976 31.87938  0.540 22.57532 ? 1043 GLU A CD    1 
ATOM   273  C CD    B GLU A 1 35  ? 16.20001  -11.24131 28.14319  0.460 23.42243 ? 1043 GLU A CD    1 
ATOM   274  O OE1   A GLU A 1 35  ? 13.09045  -10.32266 31.77403  0.540 29.62424 ? 1043 GLU A OE1   1 
ATOM   275  O OE1   B GLU A 1 35  ? 17.05599  -12.00637 28.64217  0.460 17.54689 ? 1043 GLU A OE1   1 
ATOM   276  O OE2   A GLU A 1 35  ? 14.30574  -11.69955 32.98044  0.540 23.92236 ? 1043 GLU A OE2   1 
ATOM   277  O OE2   B GLU A 1 35  ? 16.46755  -10.09150 27.72491  0.460 29.92078 ? 1043 GLU A OE2   1 
ATOM   278  N N     . SER A 1 36  ? 10.93328  -10.81655 28.00263  1.000 14.68346 ? 1044 SER A N     1 
ATOM   279  C CA    . SER A 1 36  ? 10.28916  -10.31912 26.79431  1.000 15.01546 ? 1044 SER A CA    1 
ATOM   280  C C     . SER A 1 36  ? 11.29572  -9.54709  25.95219  1.000 13.42749 ? 1044 SER A C     1 
ATOM   281  O O     . SER A 1 36  ? 12.10356  -8.78093  26.47680  1.000 15.03986 ? 1044 SER A O     1 
ATOM   282  C CB    . SER A 1 36  ? 9.12926   -9.38546  27.14752  1.000 15.03612 ? 1044 SER A CB    1 
ATOM   283  O OG    . SER A 1 36  ? 8.59597   -8.83535  25.94514  1.000 16.36950 ? 1044 SER A OG    1 
ATOM   284  N N     . LEU A 1 37  ? 11.22252  -9.73073  24.63650  1.000 12.67092 ? 1045 LEU A N     1 
ATOM   285  C CA    . LEU A 1 37  ? 12.06372  -9.02053  23.68899  1.000 13.65452 ? 1045 LEU A CA    1 
ATOM   286  C C     . LEU A 1 37  ? 11.36950  -7.82162  23.05979  1.000 14.05243 ? 1045 LEU A C     1 
ATOM   287  O O     . LEU A 1 37  ? 11.98121  -7.13903  22.23405  1.000 16.54407 ? 1045 LEU A O     1 
ATOM   288  C CB    . LEU A 1 37  ? 12.49610  -9.98236  22.57414  1.000 13.25956 ? 1045 LEU A CB    1 
ATOM   289  C CG    . LEU A 1 37  ? 13.50116  -11.06160 22.98975  1.000 12.42272 ? 1045 LEU A CG    1 
ATOM   290  C CD1   . LEU A 1 37  ? 13.60488  -12.16302 21.94357  1.000 12.92428 ? 1045 LEU A CD1   1 
ATOM   291  C CD2   . LEU A 1 37  ? 14.87433  -10.42938 23.24625  1.000 14.70712 ? 1045 LEU A CD2   1 
ATOM   292  N N     . VAL A 1 38  ? 10.11019  -7.55122  23.41207  1.000 14.52691 ? 1046 VAL A N     1 
ATOM   293  C CA    . VAL A 1 38  ? 9.29511   -6.62558  22.63463  1.000 15.41063 ? 1046 VAL A CA    1 
ATOM   294  C C     . VAL A 1 38  ? 8.66353   -5.56536  23.52905  1.000 14.18826 ? 1046 VAL A C     1 
ATOM   295  O O     . VAL A 1 38  ? 8.49589   -5.74752  24.73862  1.000 17.55725 ? 1046 VAL A O     1 
ATOM   296  C CB    . VAL A 1 38  ? 8.21354   -7.36542  21.80303  1.000 14.02716 ? 1046 VAL A CB    1 
ATOM   297  C CG1   . VAL A 1 38  ? 8.87168   -8.30977  20.78370  1.000 16.79905 ? 1046 VAL A CG1   1 
ATOM   298  C CG2   . VAL A 1 38  ? 7.26227   -8.12987  22.70685  1.000 16.18563 ? 1046 VAL A CG2   1 
ATOM   299  N N     . GLY A 1 39  ? 8.30448   -4.44106  22.90071  1.000 15.97605 ? 1047 GLY A N     1 
ATOM   300  C CA    . GLY A 1 39  ? 7.67186   -3.33580  23.58629  1.000 19.53528 ? 1047 GLY A CA    1 
ATOM   301  C C     . GLY A 1 39  ? 6.15986   -3.45116  23.60322  1.000 19.54141 ? 1047 GLY A C     1 
ATOM   302  O O     . GLY A 1 39  ? 5.56942   -4.37856  23.04152  1.000 18.75858 ? 1047 GLY A O     1 
ATOM   303  N N     . PRO A 1 40  ? 5.49996   -2.48710  24.25418  1.000 23.25474 ? 1048 PRO A N     1 
ATOM   304  C CA    . PRO A 1 40  ? 4.05244   -2.61757  24.49227  1.000 25.19429 ? 1048 PRO A CA    1 
ATOM   305  C C     . PRO A 1 40  ? 3.19150   -2.53605  23.24182  1.000 21.03074 ? 1048 PRO A C     1 
ATOM   306  O O     . PRO A 1 40  ? 2.05523   -3.02944  23.26903  1.000 26.97180 ? 1048 PRO A O     1 
ATOM   307  C CB    . PRO A 1 40  ? 3.74513   -1.47526  25.47146  1.000 30.22756 ? 1048 PRO A CB    1 
ATOM   308  C CG    . PRO A 1 40  ? 4.86140   -0.50169  25.28241  1.000 28.47078 ? 1048 PRO A CG    1 
ATOM   309  C CD    . PRO A 1 40  ? 6.07752   -1.31331  24.92614  1.000 26.55937 ? 1048 PRO A CD    1 
ATOM   310  N N     . LYS A 1 41  ? 3.69233   -1.97183  22.14602  1.000 24.82412 ? 1049 LYS A N     1 
ATOM   311  C CA    . LYS A 1 41  ? 2.92401   -1.88819  20.90795  1.000 25.34176 ? 1049 LYS A CA    1 
ATOM   312  C C     . LYS A 1 41  ? 3.05620   -3.12338  20.01764  1.000 24.21095 ? 1049 LYS A C     1 
ATOM   313  O O     . LYS A 1 41  ? 2.40651   -3.18493  18.96607  1.000 25.22536 ? 1049 LYS A O     1 
ATOM   314  C CB    . LYS A 1 41  ? 3.29829   -0.62973  20.11388  1.000 30.79022 ? 1049 LYS A CB    1 
ATOM   315  C CG    . LYS A 1 41  ? 3.10200   0.66963   20.87859  1.000 34.49087 ? 1049 LYS A CG    1 
ATOM   316  C CD    . LYS A 1 41  ? 3.04542   1.84684   19.92188  1.000 41.25965 ? 1049 LYS A CD    1 
ATOM   317  C CE    . LYS A 1 41  ? 4.38818   2.54209   19.81847  1.000 46.42366 ? 1049 LYS A CE    1 
ATOM   318  N NZ    . LYS A 1 41  ? 4.24826   4.00649   19.58219  1.000 51.55373 ? 1049 LYS A NZ    1 
ATOM   319  N N     . ALA A 1 42  ? 3.87240   -4.10302  20.39881  1.000 22.37171 ? 1050 ALA A N     1 
ATOM   320  C CA    . ALA A 1 42  ? 3.97155   -5.31297  19.59863  1.000 18.98543 ? 1050 ALA A CA    1 
ATOM   321  C C     . ALA A 1 42  ? 2.63391   -6.05467  19.61044  1.000 22.28685 ? 1050 ALA A C     1 
ATOM   322  O O     . ALA A 1 42  ? 1.97090   -6.12463  20.65083  1.000 22.28913 ? 1050 ALA A O     1 
ATOM   323  C CB    . ALA A 1 42  ? 5.08087   -6.21548  20.14597  1.000 19.83767 ? 1050 ALA A CB    1 
ATOM   324  N N     . PRO A 1 43  ? 2.20695   -6.61715  18.47487  1.000 19.59279 ? 1051 PRO A N     1 
ATOM   325  C CA    . PRO A 1 43  ? 0.91536   -7.32741  18.44356  1.000 25.29978 ? 1051 PRO A CA    1 
ATOM   326  C C     . PRO A 1 43  ? 0.85937   -8.52691  19.36927  1.000 32.49296 ? 1051 PRO A C     1 
ATOM   327  O O     . PRO A 1 43  ? -0.22967  -8.92244  19.80741  1.000 26.98799 ? 1051 PRO A O     1 
ATOM   328  C CB    . PRO A 1 43  ? 0.78391   -7.75968  16.97350  1.000 29.95502 ? 1051 PRO A CB    1 
ATOM   329  C CG    . PRO A 1 43  ? 1.73644   -6.89470  16.21895  1.000 26.97143 ? 1051 PRO A CG    1 
ATOM   330  C CD    . PRO A 1 43  ? 2.86487   -6.60174  17.15800  1.000 22.94796 ? 1051 PRO A CD    1 
ATOM   331  N N     . GLY A 1 44  ? 2.00212   -9.13146  19.67307  1.000 24.60616 ? 1052 GLY A N     1 
ATOM   332  C CA    . GLY A 1 44  ? 2.04214   -10.26291 20.56988  1.000 22.44071 ? 1052 GLY A CA    1 
ATOM   333  C C     . GLY A 1 44  ? 3.39755   -10.30239 21.23792  1.000 18.13740 ? 1052 GLY A C     1 
ATOM   334  O O     . GLY A 1 44  ? 4.28520   -9.50589  20.93123  1.000 19.82291 ? 1052 GLY A O     1 
ATOM   335  N N     . GLU A 1 45  ? 3.54788   -11.24645 22.15478  1.000 17.70005 ? 1053 GLU A N     1 
ATOM   336  C CA    A GLU A 1 45  ? 4.77686   -11.36030 22.92278  0.560 17.29192 ? 1053 GLU A CA    1 
ATOM   337  C CA    B GLU A 1 45  ? 4.76219   -11.38877 22.94015  0.440 17.33621 ? 1053 GLU A CA    1 
ATOM   338  C C     . GLU A 1 45  ? 5.74228   -12.33123 22.25487  1.000 14.25578 ? 1053 GLU A C     1 
ATOM   339  O O     . GLU A 1 45  ? 5.34307   -13.37397 21.72642  1.000 15.09288 ? 1053 GLU A O     1 
ATOM   340  C CB    A GLU A 1 45  ? 4.47758   -11.83678 24.34177  0.560 19.08654 ? 1053 GLU A CB    1 
ATOM   341  C CB    B GLU A 1 45  ? 4.39563   -11.96589 24.30395  0.440 18.93368 ? 1053 GLU A CB    1 
ATOM   342  C CG    A GLU A 1 45  ? 5.71163   -11.92023 25.21807  0.560 20.48399 ? 1053 GLU A CG    1 
ATOM   343  C CG    B GLU A 1 45  ? 5.58846   -12.39736 25.09620  0.440 19.78760 ? 1053 GLU A CG    1 
ATOM   344  C CD    A GLU A 1 45  ? 5.37352   -11.86440 26.69112  0.560 21.98520 ? 1053 GLU A CD    1 
ATOM   345  C CD    B GLU A 1 45  ? 6.18268   -11.24446 25.85214  0.440 20.71276 ? 1053 GLU A CD    1 
ATOM   346  O OE1   A GLU A 1 45  ? 4.87328   -12.87655 27.22177  0.560 26.00685 ? 1053 GLU A OE1   1 
ATOM   347  O OE1   B GLU A 1 45  ? 6.84991   -10.41248 25.20140  0.440 21.33166 ? 1053 GLU A OE1   1 
ATOM   348  O OE2   A GLU A 1 45  ? 5.58393   -10.80097 27.30866  0.560 26.44183 ? 1053 GLU A OE2   1 
ATOM   349  O OE2   B GLU A 1 45  ? 5.98099   -11.16697 27.08411  0.440 26.87055 ? 1053 GLU A OE2   1 
ATOM   350  N N     . THR A 1 46  ? 7.02702   -11.95808 22.27123  1.000 15.10818 ? 1054 THR A N     1 
ATOM   351  C CA    . THR A 1 46  ? 8.12936   -12.82978 21.87317  1.000 13.34394 ? 1054 THR A CA    1 
ATOM   352  C C     . THR A 1 46  ? 9.16487   -12.76741 22.98768  1.000 11.39653 ? 1054 THR A C     1 
ATOM   353  O O     . THR A 1 46  ? 9.51055   -11.67618 23.44750  1.000 13.30017 ? 1054 THR A O     1 
ATOM   354  C CB    . THR A 1 46  ? 8.76490   -12.38778 20.54673  1.000 12.92928 ? 1054 THR A CB    1 
ATOM   355  O OG1   . THR A 1 46  ? 7.77038   -12.42706 19.52547  1.000 15.26170 ? 1054 THR A OG1   1 
ATOM   356  C CG2   . THR A 1 46  ? 9.87858   -13.34772 20.13264  1.000 13.63002 ? 1054 THR A CG2   1 
ATOM   357  N N     . CYS A 1 47  ? 9.63301   -13.93184 23.43763  1.000 11.61964 ? 1055 CYS A N     1 
ATOM   358  C CA    . CYS A 1 47  ? 10.51533  -14.00492 24.58764  1.000 11.86149 ? 1055 CYS A CA    1 
ATOM   359  C C     . CYS A 1 47  ? 11.83048  -14.68317 24.22202  1.000 10.86862 ? 1055 CYS A C     1 
ATOM   360  O O     . CYS A 1 47  ? 11.88237  -15.57179 23.36714  1.000 11.90991 ? 1055 CYS A O     1 
ATOM   361  C CB    . CYS A 1 47  ? 9.85313   -14.83920 25.68900  1.000 13.48645 ? 1055 CYS A CB    1 
ATOM   362  S SG    . CYS A 1 47  ? 8.42098   -14.03316 26.44154  1.000 17.71230 ? 1055 CYS A SG    1 
ATOM   363  N N     . HIS A 1 48  ? 12.88064  -14.28432 24.93965  1.000 12.43931 ? 1056 HIS A N     1 
ATOM   364  C CA    . HIS A 1 48  ? 14.18786  -14.92715 24.87574  1.000 12.53292 ? 1056 HIS A CA    1 
ATOM   365  C C     . HIS A 1 48  ? 14.28523  -15.88042 26.06078  1.000 13.36596 ? 1056 HIS A C     1 
ATOM   366  O O     . HIS A 1 48  ? 14.11295  -15.45539 27.20747  1.000 12.85923 ? 1056 HIS A O     1 
ATOM   367  C CB    . HIS A 1 48  ? 15.26994  -13.84934 24.96533  1.000 13.21146 ? 1056 HIS A CB    1 
ATOM   368  C CG    . HIS A 1 48  ? 16.64569  -14.33367 24.62567  1.000 12.94069 ? 1056 HIS A CG    1 
ATOM   369  N ND1   . HIS A 1 48  ? 17.03663  -14.60280 23.33480  1.000 12.51124 ? 1056 HIS A ND1   1 
ATOM   370  C CD2   . HIS A 1 48  ? 17.74182  -14.52663 25.40148  1.000 13.57526 ? 1056 HIS A CD2   1 
ATOM   371  C CE1   . HIS A 1 48  ? 18.30107  -14.98806 23.33121  1.000 13.03833 ? 1056 HIS A CE1   1 
ATOM   372  N NE2   . HIS A 1 48  ? 18.75238  -14.95153 24.57361  1.000 12.93166 ? 1056 HIS A NE2   1 
ATOM   373  N N     . ILE A 1 49  ? 14.52989  -17.15908 25.78482  1.000 11.86946 ? 1057 ILE A N     1 
ATOM   374  C CA    . ILE A 1 49  ? 14.52146  -18.22173 26.79223  1.000 11.74398 ? 1057 ILE A CA    1 
ATOM   375  C C     . ILE A 1 49  ? 15.92676  -18.79567 26.86744  1.000 10.73358 ? 1057 ILE A C     1 
ATOM   376  O O     . ILE A 1 49  ? 16.41329  -19.34979 25.87775  1.000 12.32624 ? 1057 ILE A O     1 
ATOM   377  C CB    . ILE A 1 49  ? 13.57293  -19.35574 26.37034  1.000 12.65340 ? 1057 ILE A CB    1 
ATOM   378  C CG1   . ILE A 1 49  ? 12.27927  -18.83144 25.72470  1.000 22.73053 ? 1057 ILE A CG1   1 
ATOM   379  C CG2   . ILE A 1 49  ? 13.36405  -20.34874 27.51746  1.000 14.76361 ? 1057 ILE A CG2   1 
ATOM   380  C CD1   . ILE A 1 49  ? 11.25387  -18.39920 26.67680  1.000 21.72559 ? 1057 ILE A CD1   1 
ATOM   381  N N     . VAL A 1 50  ? 16.56327  -18.71905 28.03513  1.000 10.99638 ? 1058 VAL A N     1 
ATOM   382  C CA    . VAL A 1 50  ? 17.89974  -19.28475 28.22598  1.000 11.61397 ? 1058 VAL A CA    1 
ATOM   383  C C     . VAL A 1 50  ? 17.76465  -20.59553 28.99211  1.000 10.96946 ? 1058 VAL A C     1 
ATOM   384  O O     . VAL A 1 50  ? 17.13512  -20.63358 30.06300  1.000 11.59535 ? 1058 VAL A O     1 
ATOM   385  C CB    . VAL A 1 50  ? 18.82618  -18.30263 28.96035  1.000 11.86968 ? 1058 VAL A CB    1 
ATOM   386  C CG1   . VAL A 1 50  ? 20.20669  -18.91735 29.10360  1.000 13.69385 ? 1058 VAL A CG1   1 
ATOM   387  C CG2   . VAL A 1 50  ? 18.93153  -16.95557 28.21075  1.000 13.34396 ? 1058 VAL A CG2   1 
ATOM   388  N N     . ILE A 1 51  ? 18.34301  -21.66611 28.44572  1.000 10.02458 ? 1059 ILE A N     1 
ATOM   389  C CA    . ILE A 1 51  ? 18.17104  -23.02970 28.95089  1.000 10.16882 ? 1059 ILE A CA    1 
ATOM   390  C C     . ILE A 1 51  ? 19.53971  -23.61699 29.29111  1.000 10.67268 ? 1059 ILE A C     1 
ATOM   391  O O     . ILE A 1 51  ? 20.42559  -23.66795 28.43002  1.000 11.15836 ? 1059 ILE A O     1 
ATOM   392  C CB    . ILE A 1 51  ? 17.45801  -23.90155 27.90132  1.000 11.64418 ? 1059 ILE A CB    1 
ATOM   393  C CG1   . ILE A 1 51  ? 16.08093  -23.30254 27.56661  1.000 13.64500 ? 1059 ILE A CG1   1 
ATOM   394  C CG2   . ILE A 1 51  ? 17.38068  -25.36048 28.36521  1.000 12.71319 ? 1059 ILE A CG2   1 
ATOM   395  C CD1   . ILE A 1 51  ? 15.38130  -23.93344 26.37375  1.000 16.99972 ? 1059 ILE A CD1   1 
ATOM   396  N N     . ASP A 1 52  ? 19.69944  -24.11621 30.52248  1.000 11.02064 ? 1060 ASP A N     1 
ATOM   397  C CA    . ASP A 1 52  ? 20.92693  -24.78361 30.95794  1.000 12.80998 ? 1060 ASP A CA    1 
ATOM   398  C C     . ASP A 1 52  ? 20.85723  -26.25443 30.55213  1.000 11.79623 ? 1060 ASP A C     1 
ATOM   399  O O     . ASP A 1 52  ? 20.03309  -27.01450 31.07965  1.000 12.27525 ? 1060 ASP A O     1 
ATOM   400  C CB    . ASP A 1 52  ? 21.05333  -24.59697 32.47374  1.000 13.77919 ? 1060 ASP A CB    1 
ATOM   401  C CG    . ASP A 1 52  ? 22.27755  -25.24276 33.07140  1.000 17.44732 ? 1060 ASP A CG    1 
ATOM   402  O OD1   . ASP A 1 52  ? 23.07102  -25.88506 32.37169  1.000 16.87625 ? 1060 ASP A OD1   1 
ATOM   403  O OD2   . ASP A 1 52  ? 22.43801  -25.07610 34.29966  1.000 24.83742 ? 1060 ASP A OD2   1 
ATOM   404  N N     . HIS A 1 53  ? 21.69637  -26.65864 29.59214  1.000 11.06570 ? 1061 HIS A N     1 
ATOM   405  C CA    . HIS A 1 53  ? 21.82892  -28.06026 29.22430  1.000 12.54477 ? 1061 HIS A CA    1 
ATOM   406  C C     . HIS A 1 53  ? 23.08810  -28.69439 29.79804  1.000 12.77150 ? 1061 HIS A C     1 
ATOM   407  O O     . HIS A 1 53  ? 23.30486  -29.89138 29.60260  1.000 13.58228 ? 1061 HIS A O     1 
ATOM   408  C CB    . HIS A 1 53  ? 21.76977  -28.24814 27.70183  1.000 13.68262 ? 1061 HIS A CB    1 
ATOM   409  C CG    . HIS A 1 53  ? 22.94062  -27.67885 26.95248  1.000 11.45408 ? 1061 HIS A CG    1 
ATOM   410  N ND1   . HIS A 1 53  ? 24.05495  -28.43054 26.63854  1.000 12.87121 ? 1061 HIS A ND1   1 
ATOM   411  C CD2   . HIS A 1 53  ? 23.13374  -26.46197 26.38551  1.000 12.36092 ? 1061 HIS A CD2   1 
ATOM   412  C CE1   . HIS A 1 53  ? 24.89395  -27.69080 25.93195  1.000 13.36411 ? 1061 HIS A CE1   1 
ATOM   413  N NE2   . HIS A 1 53  ? 24.36523  -26.49189 25.77537  1.000 11.06877 ? 1061 HIS A NE2   1 
ATOM   414  N N     . GLY A 1 54  ? 23.91297  -27.91566 30.49295  1.000 13.64328 ? 1062 GLY A N     1 
ATOM   415  C CA    . GLY A 1 54  ? 25.07819  -28.44031 31.18603  1.000 14.67276 ? 1062 GLY A CA    1 
ATOM   416  C C     . GLY A 1 54  ? 26.16938  -28.98730 30.29786  1.000 15.25499 ? 1062 GLY A C     1 
ATOM   417  O O     . GLY A 1 54  ? 27.07095  -29.66618 30.80262  1.000 19.54941 ? 1062 GLY A O     1 
ATOM   418  N N     . GLY A 1 55  ? 26.14015  -28.70035 28.99554  1.000 12.72381 ? 1063 GLY A N     1 
ATOM   419  C CA    . GLY A 1 55  ? 27.06865  -29.32685 28.08366  1.000 13.57242 ? 1063 GLY A CA    1 
ATOM   420  C C     . GLY A 1 55  ? 26.64250  -30.68857 27.58740  1.000 11.07442 ? 1063 GLY A C     1 
ATOM   421  O O     . GLY A 1 55  ? 27.37387  -31.30058 26.80205  1.000 13.25507 ? 1063 GLY A O     1 
ATOM   422  N N     . ASN A 1 56  ? 25.47347  -31.18792 28.01687  1.000 11.12528 ? 1064 ASN A N     1 
ATOM   423  C CA    . ASN A 1 56  ? 25.00049  -32.49903 27.60320  1.000 12.43626 ? 1064 ASN A CA    1 
ATOM   424  C C     . ASN A 1 56  ? 24.29303  -32.49134 26.25894  1.000 12.49508 ? 1064 ASN A C     1 
ATOM   425  O O     . ASN A 1 56  ? 24.15069  -33.55668 25.65158  1.000 13.74282 ? 1064 ASN A O     1 
ATOM   426  C CB    . ASN A 1 56  ? 24.02631  -33.04935 28.64637  1.000 13.87774 ? 1064 ASN A CB    1 
ATOM   427  C CG    . ASN A 1 56  ? 24.69670  -33.31667 29.97463  1.000 15.48452 ? 1064 ASN A CG    1 
ATOM   428  O OD1   . ASN A 1 56  ? 25.43028  -34.29152 30.11978  1.000 19.41496 ? 1064 ASN A OD1   1 
ATOM   429  N ND2   . ASN A 1 56  ? 24.46440  -32.44124 30.94553  1.000 15.60450 ? 1064 ASN A ND2   1 
ATOM   430  N N     . VAL A 1 57  ? 23.83580  -31.33259 25.78243  1.000 12.95339 ? 1065 VAL A N     1 
ATOM   431  C CA    . VAL A 1 57  ? 23.15963  -31.28200 24.48694  1.000 11.85439 ? 1065 VAL A CA    1 
ATOM   432  C C     . VAL A 1 57  ? 23.82443  -30.23412 23.59342  1.000 11.24594 ? 1065 VAL A C     1 
ATOM   433  O O     . VAL A 1 57  ? 23.17516  -29.25634 23.19105  1.000 11.72705 ? 1065 VAL A O     1 
ATOM   434  C CB    . VAL A 1 57  ? 21.63973  -31.06412 24.63590  1.000 11.18098 ? 1065 VAL A CB    1 
ATOM   435  C CG1   . VAL A 1 57  ? 20.94270  -31.50075 23.34577  1.000 12.15537 ? 1065 VAL A CG1   1 
ATOM   436  C CG2   . VAL A 1 57  ? 21.07458  -31.83215 25.84189  1.000 14.78364 ? 1065 VAL A CG2   1 
ATOM   437  N N     . PRO A 1 58  ? 25.10243  -30.39760 23.24431  1.000 10.44890 ? 1066 PRO A N     1 
ATOM   438  C CA    . PRO A 1 58  ? 25.75400  -29.43706 22.34132  1.000 11.31401 ? 1066 PRO A CA    1 
ATOM   439  C C     . PRO A 1 58  ? 25.15512  -29.47017 20.93878  1.000 11.17026 ? 1066 PRO A C     1 
ATOM   440  O O     . PRO A 1 58  ? 24.50719  -30.43700 20.51802  1.000 11.66053 ? 1066 PRO A O     1 
ATOM   441  C CB    . PRO A 1 58  ? 27.20790  -29.92360 22.31171  1.000 11.41643 ? 1066 PRO A CB    1 
ATOM   442  C CG    . PRO A 1 58  ? 27.11472  -31.41557 22.56845  1.000 10.94972 ? 1066 PRO A CG    1 
ATOM   443  C CD    . PRO A 1 58  ? 25.99373  -31.51965 23.59632  1.000 10.88334 ? 1066 PRO A CD    1 
ATOM   444  N N     . TYR A 1 59  ? 25.41074  -28.38958 20.19543  1.000 10.40063 ? 1067 TYR A N     1 
ATOM   445  C CA    . TYR A 1 59  ? 24.82195  -28.20048 18.87283  1.000 10.79378 ? 1067 TYR A CA    1 
ATOM   446  C C     . TYR A 1 59  ? 25.73157  -27.27779 18.07476  1.000 11.34180 ? 1067 TYR A C     1 
ATOM   447  O O     . TYR A 1 59  ? 26.65238  -26.66750 18.61587  1.000 11.39867 ? 1067 TYR A O     1 
ATOM   448  C CB    . TYR A 1 59  ? 23.42774  -27.55884 18.99348  1.000 11.25167 ? 1067 TYR A CB    1 
ATOM   449  C CG    . TYR A 1 59  ? 23.45017  -26.28318 19.81107  1.000 9.96885  ? 1067 TYR A CG    1 
ATOM   450  C CD1   . TYR A 1 59  ? 23.73406  -25.04658 19.21756  1.000 10.51122 ? 1067 TYR A CD1   1 
ATOM   451  C CD2   . TYR A 1 59  ? 23.25481  -26.32506 21.18416  1.000 9.96524  ? 1067 TYR A CD2   1 
ATOM   452  C CE1   . TYR A 1 59  ? 23.79079  -23.88355 19.97355  1.000 10.04306 ? 1067 TYR A CE1   1 
ATOM   453  C CE2   . TYR A 1 59  ? 23.31042  -25.17600 21.95058  1.000 10.22610 ? 1067 TYR A CE2   1 
ATOM   454  C CZ    . TYR A 1 59  ? 23.57975  -23.95226 21.34318  1.000 9.15005  ? 1067 TYR A CZ    1 
ATOM   455  O OH    . TYR A 1 59  ? 23.64272  -22.81596 22.10186  1.000 10.63392 ? 1067 TYR A OH    1 
ATOM   456  N N     . TRP A 1 60  ? 25.44312  -27.16513 16.78161  1.000 11.44098 ? 1068 TRP A N     1 
ATOM   457  C CA    . TRP A 1 60  ? 26.09494  -26.19191 15.91515  1.000 10.31090 ? 1068 TRP A CA    1 
ATOM   458  C C     . TRP A 1 60  ? 25.09582  -25.08972 15.58363  1.000 11.78054 ? 1068 TRP A C     1 
ATOM   459  O O     . TRP A 1 60  ? 23.87162  -25.28999 15.65351  1.000 10.76248 ? 1068 TRP A O     1 
ATOM   460  C CB    . TRP A 1 60  ? 26.57276  -26.83953 14.60917  1.000 12.21521 ? 1068 TRP A CB    1 
ATOM   461  C CG    . TRP A 1 60  ? 27.79802  -27.69817 14.75236  1.000 10.74005 ? 1068 TRP A CG    1 
ATOM   462  C CD1   . TRP A 1 60  ? 28.42608  -28.07354 15.91599  1.000 12.00168 ? 1068 TRP A CD1   1 
ATOM   463  C CD2   . TRP A 1 60  ? 28.52056  -28.30473 13.68636  1.000 13.43164 ? 1068 TRP A CD2   1 
ATOM   464  N NE1   . TRP A 1 60  ? 29.50969  -28.87160 15.61899  1.000 13.36856 ? 1068 TRP A NE1   1 
ATOM   465  C CE2   . TRP A 1 60  ? 29.59331  -29.02139 14.25830  1.000 13.75256 ? 1068 TRP A CE2   1 
ATOM   466  C CE3   . TRP A 1 60  ? 28.38357  -28.28230 12.29274  1.000 15.27625 ? 1068 TRP A CE3   1 
ATOM   467  C CZ2   . TRP A 1 60  ? 30.51350  -29.72716 13.48298  1.000 14.57160 ? 1068 TRP A CZ2   1 
ATOM   468  C CZ3   . TRP A 1 60  ? 29.28964  -28.98617 11.52769  1.000 17.67049 ? 1068 TRP A CZ3   1 
ATOM   469  C CH2   . TRP A 1 60  ? 30.34203  -29.69922 12.12149  1.000 18.82141 ? 1068 TRP A CH2   1 
ATOM   470  N N     . GLU A 1 61  ? 25.62225  -23.92550 15.20857  1.000 9.69111  ? 1069 GLU A N     1 
ATOM   471  C CA    . GLU A 1 61  ? 24.76645  -22.80634 14.84311  1.000 9.65548  ? 1069 GLU A CA    1 
ATOM   472  C C     . GLU A 1 61  ? 23.85601  -23.19231 13.67801  1.000 11.09732 ? 1069 GLU A C     1 
ATOM   473  O O     . GLU A 1 61  ? 24.26893  -23.89314 12.74995  1.000 11.54662 ? 1069 GLU A O     1 
ATOM   474  C CB    . GLU A 1 61  ? 25.63395  -21.58963 14.48301  1.000 10.96859 ? 1069 GLU A CB    1 
ATOM   475  C CG    . GLU A 1 61  ? 26.39400  -21.01240 15.67692  1.000 11.76245 ? 1069 GLU A CG    1 
ATOM   476  C CD    . GLU A 1 61  ? 27.67593  -21.77868 16.01535  1.000 9.86024  ? 1069 GLU A CD    1 
ATOM   477  O OE1   . GLU A 1 61  ? 28.13386  -22.63059 15.22779  1.000 11.44474 ? 1069 GLU A OE1   1 
ATOM   478  O OE2   . GLU A 1 61  ? 28.22072  -21.52789 17.12425  1.000 11.79184 ? 1069 GLU A OE2   1 
ATOM   479  N N     . GLY A 1 62  ? 22.60209  -22.74427 13.74697  1.000 9.75079  ? 1070 GLY A N     1 
ATOM   480  C CA    . GLY A 1 62  ? 21.62609  -23.08834 12.73141  1.000 10.56502 ? 1070 GLY A CA    1 
ATOM   481  C C     . GLY A 1 62  ? 20.74634  -24.28778 13.04964  1.000 11.85648 ? 1070 GLY A C     1 
ATOM   482  O O     . GLY A 1 62  ? 19.73161  -24.49410 12.35397  1.000 13.25170 ? 1070 GLY A O     1 
ATOM   483  N N     . GLN A 1 63  ? 21.09944  -25.09631 14.04479  1.000 10.46299 ? 1071 GLN A N     1 
ATOM   484  C CA    . GLN A 1 63  ? 20.27573  -26.23857 14.41335  1.000 9.76484  ? 1071 GLN A CA    1 
ATOM   485  C C     . GLN A 1 63  ? 19.09811  -25.81217 15.29523  1.000 8.75816  ? 1071 GLN A C     1 
ATOM   486  O O     . GLN A 1 63  ? 18.97558  -24.66137 15.72532  1.000 11.32302 ? 1071 GLN A O     1 
ATOM   487  C CB    . GLN A 1 63  ? 21.13776  -27.28767 15.11429  1.000 11.31920 ? 1071 GLN A CB    1 
ATOM   488  C CG    . GLN A 1 63  ? 22.22617  -27.87069 14.20474  1.000 10.47854 ? 1071 GLN A CG    1 
ATOM   489  C CD    . GLN A 1 63  ? 22.84477  -29.11982 14.81024  1.000 10.72303 ? 1071 GLN A CD    1 
ATOM   490  O OE1   . GLN A 1 63  ? 23.57345  -29.03591 15.79978  1.000 12.81554 ? 1071 GLN A OE1   1 
ATOM   491  N NE2   . GLN A 1 63  ? 22.52819  -30.28528 14.25089  1.000 12.66284 ? 1071 GLN A NE2   1 
ATOM   492  N N     . SER A 1 64  ? 18.21316  -26.77968 15.56172  1.000 11.55622 ? 1072 SER A N     1 
ATOM   493  C CA    A SER A 1 64  ? 17.03111  -26.58423 16.39641  0.773 10.11792 ? 1072 SER A CA    1 
ATOM   494  C CA    B SER A 1 64  ? 17.05988  -26.55970 16.41869  0.227 10.08144 ? 1072 SER A CA    1 
ATOM   495  C C     . SER A 1 64  ? 17.07734  -27.53477 17.58740  1.000 10.43220 ? 1072 SER A C     1 
ATOM   496  O O     . SER A 1 64  ? 17.63804  -28.62802 17.50239  1.000 12.10484 ? 1072 SER A O     1 
ATOM   497  C CB    A SER A 1 64  ? 15.74186  -26.90382 15.60157  0.773 12.24869 ? 1072 SER A CB    1 
ATOM   498  C CB    B SER A 1 64  ? 15.75410  -26.73752 15.63781  0.227 12.52896 ? 1072 SER A CB    1 
ATOM   499  O OG    A SER A 1 64  ? 15.51480  -25.93441 14.58485  0.773 12.94868 ? 1072 SER A OG    1 
ATOM   500  O OG    B SER A 1 64  ? 15.61291  -28.07838 15.21560  0.227 14.24650 ? 1072 SER A OG    1 
ATOM   501  N N     . TYR A 1 65  ? 16.46832  -27.11181 18.69072  1.000 10.85648 ? 1073 TYR A N     1 
ATOM   502  C CA    . TYR A 1 65  ? 16.17598  -28.00099 19.80385  1.000 9.09481  ? 1073 TYR A CA    1 
ATOM   503  C C     . TYR A 1 65  ? 14.71907  -28.43000 19.69161  1.000 11.40331 ? 1073 TYR A C     1 
ATOM   504  O O     . TYR A 1 65  ? 13.86494  -27.65614 19.24321  1.000 12.06951 ? 1073 TYR A O     1 
ATOM   505  C CB    . TYR A 1 65  ? 16.33454  -27.26973 21.14180  1.000 11.47638 ? 1073 TYR A CB    1 
ATOM   506  C CG    . TYR A 1 65  ? 17.71326  -27.25802 21.79731  1.000 10.69003 ? 1073 TYR A CG    1 
ATOM   507  C CD1   . TYR A 1 65  ? 18.59319  -28.33266 21.67450  1.000 12.10599 ? 1073 TYR A CD1   1 
ATOM   508  C CD2   . TYR A 1 65  ? 18.09996  -26.18102 22.57899  1.000 11.91608 ? 1073 TYR A CD2   1 
ATOM   509  C CE1   . TYR A 1 65  ? 19.83763  -28.31825 22.31568  1.000 11.77607 ? 1073 TYR A CE1   1 
ATOM   510  C CE2   . TYR A 1 65  ? 19.32114  -26.16719 23.22886  1.000 12.41930 ? 1073 TYR A CE2   1 
ATOM   511  C CZ    . TYR A 1 65  ? 20.18170  -27.23442 23.08164  1.000 11.41978 ? 1073 TYR A CZ    1 
ATOM   512  O OH    . TYR A 1 65  ? 21.38363  -27.19687 23.75225  1.000 10.78486 ? 1073 TYR A OH    1 
ATOM   513  N N     . GLY A 1 66  ? 14.44105  -29.66973 20.09239  1.000 10.57129 ? 1074 GLY A N     1 
ATOM   514  C CA    . GLY A 1 66  ? 13.06218  -30.09329 20.31993  1.000 12.17483 ? 1074 GLY A CA    1 
ATOM   515  C C     . GLY A 1 66  ? 12.68793  -29.83324 21.77068  1.000 12.23419 ? 1074 GLY A C     1 
ATOM   516  O O     . GLY A 1 66  ? 13.50420  -30.00300 22.67058  1.000 10.97147 ? 1074 GLY A O     1 
ATOM   517  N N     . VAL A 1 67  ? 11.43230  -29.42693 21.98985  1.000 10.77547 ? 1075 VAL A N     1 
ATOM   518  C CA    . VAL A 1 67  ? 10.86221  -29.28827 23.32929  1.000 10.93616 ? 1075 VAL A CA    1 
ATOM   519  C C     . VAL A 1 67  ? 9.58297   -30.11336 23.38889  1.000 11.25135 ? 1075 VAL A C     1 
ATOM   520  O O     . VAL A 1 67  ? 8.72728   -30.00991 22.49369  1.000 12.29824 ? 1075 VAL A O     1 
ATOM   521  C CB    . VAL A 1 67  ? 10.55221  -27.82127 23.68766  1.000 11.58595 ? 1075 VAL A CB    1 
ATOM   522  C CG1   . VAL A 1 67  ? 9.86965   -27.73260 25.06464  1.000 12.65830 ? 1075 VAL A CG1   1 
ATOM   523  C CG2   . VAL A 1 67  ? 11.81512  -26.96840 23.63872  1.000 12.36636 ? 1075 VAL A CG2   1 
ATOM   524  N N     . ILE A 1 68  ? 9.45786   -30.94072 24.42149  1.000 11.34482 ? 1076 ILE A N     1 
ATOM   525  C CA    . ILE A 1 68  ? 8.24575   -31.72412 24.63269  1.000 12.02294 ? 1076 ILE A CA    1 
ATOM   526  C C     . ILE A 1 68  ? 7.48353   -31.06806 25.77801  1.000 12.02567 ? 1076 ILE A C     1 
ATOM   527  O O     . ILE A 1 68  ? 7.88943   -31.20343 26.94569  1.000 13.02442 ? 1076 ILE A O     1 
ATOM   528  C CB    . ILE A 1 68  ? 8.54914   -33.19881 24.93430  1.000 12.65051 ? 1076 ILE A CB    1 
ATOM   529  C CG1   . ILE A 1 68  ? 9.24235   -33.84665 23.73219  1.000 16.64568 ? 1076 ILE A CG1   1 
ATOM   530  C CG2   . ILE A 1 68  ? 7.25042   -33.96793 25.28007  1.000 16.52048 ? 1076 ILE A CG2   1 
ATOM   531  C CD1   . ILE A 1 68  ? 9.77131   -35.24776 23.98652  1.000 19.68745 ? 1076 ILE A CD1   1 
ATOM   532  N N     . PRO A 1 69  ? 6.39946   -30.34398 25.51642  1.000 11.93386 ? 1077 PRO A N     1 
ATOM   533  C CA    . PRO A 1 69  ? 5.68120   -29.71261 26.61908  1.000 14.13981 ? 1077 PRO A CA    1 
ATOM   534  C C     . PRO A 1 69  ? 5.02482   -30.77548 27.48106  1.000 14.22062 ? 1077 PRO A C     1 
ATOM   535  O O     . PRO A 1 69  ? 4.79250   -31.90299 27.01981  1.000 14.93655 ? 1077 PRO A O     1 
ATOM   536  C CB    . PRO A 1 69  ? 4.64591   -28.83216 25.90356  1.000 18.21850 ? 1077 PRO A CB    1 
ATOM   537  C CG    . PRO A 1 69  ? 4.36568   -29.56796 24.64925  1.000 17.10933 ? 1077 PRO A CG    1 
ATOM   538  C CD    . PRO A 1 69  ? 5.71072   -30.12985 24.22380  1.000 12.91021 ? 1077 PRO A CD    1 
ATOM   539  N N     . PRO A 1 70  ? 4.75482   -30.48148 28.74791  1.000 15.72543 ? 1078 PRO A N     1 
ATOM   540  C CA    A PRO A 1 70  ? 4.11280   -31.47887 29.60723  0.289 16.52551 ? 1078 PRO A CA    1 
ATOM   541  C CA    B PRO A 1 70  ? 4.11455   -31.48278 29.60493  0.711 16.45268 ? 1078 PRO A CA    1 
ATOM   542  C C     . PRO A 1 70  ? 2.67124   -31.72345 29.18779  1.000 16.01034 ? 1078 PRO A C     1 
ATOM   543  O O     . PRO A 1 70  ? 2.06475   -30.95256 28.43862  1.000 22.87406 ? 1078 PRO A O     1 
ATOM   544  C CB    A PRO A 1 70  ? 4.18534   -30.84358 30.99887  0.289 16.72184 ? 1078 PRO A CB    1 
ATOM   545  C CB    B PRO A 1 70  ? 4.20064   -30.86232 31.00381  0.711 16.69085 ? 1078 PRO A CB    1 
ATOM   546  C CG    A PRO A 1 70  ? 4.17407   -29.38485 30.73268  0.289 17.49627 ? 1078 PRO A CG    1 
ATOM   547  C CG    B PRO A 1 70  ? 4.23557   -29.40604 30.75923  0.711 17.57013 ? 1078 PRO A CG    1 
ATOM   548  C CD    A PRO A 1 70  ? 4.93752   -29.19222 29.43355  0.289 14.64282 ? 1078 PRO A CD    1 
ATOM   549  C CD    B PRO A 1 70  ? 5.02767   -29.22702 29.46067  0.711 14.52564 ? 1078 PRO A CD    1 
ATOM   550  N N     . GLY A 1 71  ? 2.13703   -32.82330 29.67434  1.000 20.95404 ? 1079 GLY A N     1 
ATOM   551  C CA    . GLY A 1 71  ? 0.76437   -33.18517 29.41100  1.000 23.40648 ? 1079 GLY A CA    1 
ATOM   552  C C     . GLY A 1 71  ? 0.64120   -34.35371 28.44960  1.000 25.84205 ? 1079 GLY A C     1 
ATOM   553  O O     . GLY A 1 71  ? 1.60923   -35.04507 28.11474  1.000 25.68044 ? 1079 GLY A O     1 
ATOM   554  N N     . GLU A 1 72  ? -0.59358  -34.56140 27.99925  1.000 30.56822 ? 1080 GLU A N     1 
ATOM   555  C CA    . GLU A 1 72  ? -0.95652  -35.70452 27.17688  1.000 30.11375 ? 1080 GLU A CA    1 
ATOM   556  C C     . GLU A 1 72  ? -1.27994  -35.23940 25.76675  1.000 27.61202 ? 1080 GLU A C     1 
ATOM   557  O O     . GLU A 1 72  ? -1.87445  -34.17265 25.57090  1.000 30.83170 ? 1080 GLU A O     1 
ATOM   558  C CB    . GLU A 1 72  ? -2.19047  -36.40037 27.75849  1.000 37.00038 ? 1080 GLU A CB    1 
ATOM   559  C CG    . GLU A 1 72  ? -2.48829  -37.77014 27.19974  1.000 41.16459 ? 1080 GLU A CG    1 
ATOM   560  C CD    . GLU A 1 72  ? -3.71393  -38.38852 27.84835  1.000 53.27184 ? 1080 GLU A CD    1 
ATOM   561  O OE1   . GLU A 1 72  ? -4.72312  -37.66757 28.02346  1.000 50.16123 ? 1080 GLU A OE1   1 
ATOM   562  O OE2   . GLU A 1 72  ? -3.66700  -39.59144 28.18001  1.000 51.74352 ? 1080 GLU A OE2   1 
ATOM   563  N N     . ASN A 1 73  ? -0.89065  -36.05025 24.79482  1.000 28.90264 ? 1081 ASN A N     1 
ATOM   564  C CA    . ASN A 1 73  ? -1.23860  -35.79212 23.41095  1.000 30.08970 ? 1081 ASN A CA    1 
ATOM   565  C C     . ASN A 1 73  ? -2.75846  -35.77101 23.29256  1.000 38.96565 ? 1081 ASN A C     1 
ATOM   566  O O     . ASN A 1 73  ? -3.40477  -36.79452 23.55952  1.000 36.52453 ? 1081 ASN A O     1 
ATOM   567  C CB    . ASN A 1 73  ? -0.65872  -36.90539 22.54523  1.000 30.73769 ? 1081 ASN A CB    1 
ATOM   568  C CG    . ASN A 1 73  ? -0.81832  -36.63601 21.05802  1.000 36.94941 ? 1081 ASN A CG    1 
ATOM   569  O OD1   . ASN A 1 73  ? -1.64899  -35.83001 20.64312  1.000 38.59631 ? 1081 ASN A OD1   1 
ATOM   570  N ND2   . ASN A 1 73  ? -0.00726  -37.30397 20.24991  1.000 41.10669 ? 1081 ASN A ND2   1 
ATOM   571  N N     . PRO A 1 74  ? -3.36645  -34.64373 22.91174  1.000 37.49058 ? 1082 PRO A N     1 
ATOM   572  C CA    . PRO A 1 74  ? -4.83625  -34.58432 22.84060  1.000 44.53745 ? 1082 PRO A CA    1 
ATOM   573  C C     . PRO A 1 74  ? -5.42486  -35.52700 21.81278  1.000 48.81347 ? 1082 PRO A C     1 
ATOM   574  O O     . PRO A 1 74  ? -6.64727  -35.72184 21.80205  1.000 55.15746 ? 1082 PRO A O     1 
ATOM   575  C CB    . PRO A 1 74  ? -5.10871  -33.11853 22.46437  1.000 46.71189 ? 1082 PRO A CB    1 
ATOM   576  C CG    . PRO A 1 74  ? -3.83310  -32.39433 22.84106  1.000 52.09896 ? 1082 PRO A CG    1 
ATOM   577  C CD    . PRO A 1 74  ? -2.76507  -33.37632 22.47136  1.000 45.17012 ? 1082 PRO A CD    1 
ATOM   578  N N     . LYS A 1 75  ? -4.59502  -36.11382 20.95438  1.000 48.88689 ? 1083 LYS A N     1 
ATOM   579  C CA    . LYS A 1 75  ? -5.04146  -37.00253 19.89638  1.000 51.81424 ? 1083 LYS A CA    1 
ATOM   580  C C     . LYS A 1 75  ? -4.63474  -38.44775 20.14414  1.000 53.53352 ? 1083 LYS A C     1 
ATOM   581  O O     . LYS A 1 75  ? -5.01785  -39.32808 19.36650  1.000 58.00812 ? 1083 LYS A O     1 
ATOM   582  C CB    . LYS A 1 75  ? -4.47920  -36.52196 18.55252  1.000 48.80615 ? 1083 LYS A CB    1 
ATOM   583  C CG    . LYS A 1 75  ? -4.94513  -35.12666 18.15557  1.000 49.84967 ? 1083 LYS A CG    1 
ATOM   584  C CD    . LYS A 1 75  ? -5.06545  -34.97502 16.64810  1.000 58.36372 ? 1083 LYS A CD    1 
ATOM   585  C CE    . LYS A 1 75  ? -5.88531  -33.74545 16.27943  1.000 62.93064 ? 1083 LYS A CE    1 
ATOM   586  N NZ    . LYS A 1 75  ? -6.95739  -33.45778 17.27350  1.000 68.00510 ? 1083 LYS A NZ    1 
ATOM   587  N N     . LYS A 1 76  ? -3.85288  -38.71108 21.19190  1.000 47.19348 ? 1084 LYS A N     1 
ATOM   588  C CA    . LYS A 1 76  ? -3.46722  -40.06933 21.57930  1.000 47.17105 ? 1084 LYS A CA    1 
ATOM   589  C C     . LYS A 1 76  ? -3.41071  -40.12679 23.09694  1.000 50.21642 ? 1084 LYS A C     1 
ATOM   590  O O     . LYS A 1 76  ? -2.34086  -39.96987 23.69769  1.000 52.67533 ? 1084 LYS A O     1 
ATOM   591  C CB    . LYS A 1 76  ? -2.10248  -40.45397 21.00191  1.000 45.89267 ? 1084 LYS A CB    1 
ATOM   592  C CG    . LYS A 1 76  ? -1.91541  -40.19764 19.51720  1.000 56.79837 ? 1084 LYS A CG    1 
ATOM   593  C CD    . LYS A 1 76  ? -0.47162  -40.44203 19.10073  1.000 62.55663 ? 1084 LYS A CD    1 
ATOM   594  C CE    . LYS A 1 76  ? -0.13844  -39.71891 17.80156  1.000 62.55301 ? 1084 LYS A CE    1 
ATOM   595  N NZ    . LYS A 1 76  ? 0.41269   -40.64577 16.77454  1.000 66.61669 ? 1084 LYS A NZ    1 
ATOM   596  N N     . PRO A 1 77  ? -4.55279  -40.32580 23.75471  1.000 55.15875 ? 1085 PRO A N     1 
ATOM   597  C CA    . PRO A 1 77  ? -4.55140  -40.50259 25.21014  1.000 48.98335 ? 1085 PRO A CA    1 
ATOM   598  C C     . PRO A 1 77  ? -3.52424  -41.53846 25.64592  1.000 46.14756 ? 1085 PRO A C     1 
ATOM   599  O O     . PRO A 1 77  ? -3.37614  -42.59620 25.02607  1.000 50.25830 ? 1085 PRO A O     1 
ATOM   600  C CB    . PRO A 1 77  ? -5.99607  -40.98768 25.47360  1.000 57.69949 ? 1085 PRO A CB    1 
ATOM   601  C CG    . PRO A 1 77  ? -6.45008  -41.31976 24.00419  1.000 57.24953 ? 1085 PRO A CG    1 
ATOM   602  C CD    . PRO A 1 77  ? -5.95373  -40.09807 23.40877  1.000 58.64355 ? 1085 PRO A CD    1 
ATOM   603  N N     . GLY A 1 78  ? -2.78581  -41.21256 26.70609  1.000 48.09686 ? 1086 GLY A N     1 
ATOM   604  C CA    . GLY A 1 78  ? -1.72401  -42.05584 27.20522  1.000 46.66778 ? 1086 GLY A CA    1 
ATOM   605  C C     . GLY A 1 78  ? -0.34786  -41.75828 26.64556  1.000 52.18338 ? 1086 GLY A C     1 
ATOM   606  O O     . GLY A 1 78  ? 0.64929   -42.19021 27.23386  1.000 52.78882 ? 1086 GLY A O     1 
ATOM   607  N N     . ALA A 1 79  ? -0.25935  -41.02085 25.50481  1.000 49.22205 ? 1087 ALA A N     1 
ATOM   608  C CA    . ALA A 1 79  ? 1.01185   -40.70391 24.87351  1.000 36.85746 ? 1087 ALA A CA    1 
ATOM   609  C C     . ALA A 1 79  ? 1.45919   -39.29460 25.24457  1.000 30.19072 ? 1087 ALA A C     1 
ATOM   610  O O     . ALA A 1 79  ? 0.62796   -38.43456 25.55993  1.000 28.56292 ? 1087 ALA A O     1 
ATOM   611  C CB    . ALA A 1 79  ? 0.88285   -40.79046 23.35045  1.000 35.14411 ? 1087 ALA A CB    1 
ATOM   612  N N     . PRO A 1 80  ? 2.76724   -39.04116 25.22265  1.000 30.29529 ? 1088 PRO A N     1 
ATOM   613  C CA    . PRO A 1 80  ? 3.26637   -37.68692 25.49810  1.000 33.47160 ? 1088 PRO A CA    1 
ATOM   614  C C     . PRO A 1 80  ? 2.89768   -36.73664 24.37063  1.000 30.49563 ? 1088 PRO A C     1 
ATOM   615  O O     . PRO A 1 80  ? 2.50852   -37.13726 23.27089  1.000 25.76867 ? 1088 PRO A O     1 
ATOM   616  C CB    . PRO A 1 80  ? 4.78952   -37.84473 25.56702  1.000 29.19088 ? 1088 PRO A CB    1 
ATOM   617  C CG    . PRO A 1 80  ? 5.09253   -39.23543 25.16356  1.000 37.22304 ? 1088 PRO A CG    1 
ATOM   618  C CD    . PRO A 1 80  ? 3.84292   -40.04160 25.13914  1.000 35.12727 ? 1088 PRO A CD    1 
ATOM   619  N N     . GLN A 1 81  ? 3.04313   -35.44901 24.66669  1.000 21.90134 ? 1089 GLN A N     1 
ATOM   620  C CA    . GLN A 1 81  ? 2.86818   -34.40399 23.67075  1.000 20.59265 ? 1089 GLN A CA    1 
ATOM   621  C C     . GLN A 1 81  ? 3.92901   -34.52346 22.58089  1.000 18.72227 ? 1089 GLN A C     1 
ATOM   622  O O     . GLN A 1 81  ? 5.04154   -35.01268 22.80673  1.000 20.15702 ? 1089 GLN A O     1 
ATOM   623  C CB    . GLN A 1 81  ? 2.97865   -33.02818 24.33471  1.000 19.36766 ? 1089 GLN A CB    1 
ATOM   624  C CG    . GLN A 1 81  ? 1.93254   -32.78706 25.41879  1.000 20.84800 ? 1089 GLN A CG    1 
ATOM   625  C CD    . GLN A 1 81  ? 0.71690   -32.07381 24.88854  1.000 22.18847 ? 1089 GLN A CD    1 
ATOM   626  O OE1   . GLN A 1 81  ? 0.34737   -32.23701 23.72504  1.000 25.32822 ? 1089 GLN A OE1   1 
ATOM   627  N NE2   . GLN A 1 81  ? 0.06995   -31.28491 25.74029  1.000 27.68503 ? 1089 GLN A NE2   1 
ATOM   628  N N     . ASN A 1 82  ? 3.57338   -34.06829 21.38617  1.000 15.95004 ? 1090 ASN A N     1 
ATOM   629  C CA    . ASN A 1 82  ? 4.53116   -34.08205 20.28810  1.000 14.90665 ? 1090 ASN A CA    1 
ATOM   630  C C     . ASN A 1 82  ? 5.62699   -33.04192 20.52136  1.000 13.63132 ? 1090 ASN A C     1 
ATOM   631  O O     . ASN A 1 82  ? 5.39813   -31.98682 21.11588  1.000 15.00981 ? 1090 ASN A O     1 
ATOM   632  C CB    . ASN A 1 82  ? 3.82936   -33.75806 18.97012  1.000 18.30600 ? 1090 ASN A CB    1 
ATOM   633  C CG    . ASN A 1 82  ? 2.84184   -34.83214 18.54301  1.000 22.31881 ? 1090 ASN A CG    1 
ATOM   634  O OD1   . ASN A 1 82  ? 3.08510   -36.02499 18.70440  1.000 23.92177 ? 1090 ASN A OD1   1 
ATOM   635  N ND2   . ASN A 1 82  ? 1.72298   -34.40018 17.97711  1.000 30.20793 ? 1090 ASN A ND2   1 
ATOM   636  N N     . VAL A 1 83  ? 6.82347   -33.35510 20.00890  1.000 14.66907 ? 1091 VAL A N     1 
ATOM   637  C CA    . VAL A 1 83  ? 7.92568   -32.39596 19.98454  1.000 14.70617 ? 1091 VAL A CA    1 
ATOM   638  C C     . VAL A 1 83  ? 7.53669   -31.17308 19.16038  1.000 12.76138 ? 1091 VAL A C     1 
ATOM   639  O O     . VAL A 1 83  ? 6.94583   -31.29178 18.07012  1.000 14.97108 ? 1091 VAL A O     1 
ATOM   640  C CB    . VAL A 1 83  ? 9.14334   -33.08055 19.33655  1.000 13.97201 ? 1091 VAL A CB    1 
ATOM   641  C CG1   . VAL A 1 83  ? 10.25748  -32.06360 19.02587  1.000 15.62155 ? 1091 VAL A CG1   1 
ATOM   642  C CG2   . VAL A 1 83  ? 9.65432   -34.21069 20.20457  1.000 17.89820 ? 1091 VAL A CG2   1 
ATOM   643  N N     . ARG A 1 84  ? 7.87663   -29.98995 19.66807  1.000 12.23114 ? 1092 ARG A N     1 
ATOM   644  C CA    . ARG A 1 84  ? 7.90802   -28.76375 18.87354  1.000 12.01830 ? 1092 ARG A CA    1 
ATOM   645  C C     . ARG A 1 84  ? 9.36042   -28.33570 18.69674  1.000 11.18966 ? 1092 ARG A C     1 
ATOM   646  O O     . ARG A 1 84  ? 10.14045  -28.36894 19.65531  1.000 12.25820 ? 1092 ARG A O     1 
ATOM   647  C CB    . ARG A 1 84  ? 7.13972   -27.64566 19.57242  1.000 12.30748 ? 1092 ARG A CB    1 
ATOM   648  C CG    . ARG A 1 84  ? 5.63839   -27.68044 19.33788  1.000 13.01888 ? 1092 ARG A CG    1 
ATOM   649  C CD    . ARG A 1 84  ? 4.95639   -28.77878 20.16328  1.000 13.24756 ? 1092 ARG A CD    1 
ATOM   650  N NE    . ARG A 1 84  ? 3.55087   -28.44939 20.37011  1.000 14.15402 ? 1092 ARG A NE    1 
ATOM   651  C CZ    . ARG A 1 84  ? 2.61930   -29.30245 20.77483  1.000 16.22281 ? 1092 ARG A CZ    1 
ATOM   652  N NH1   . ARG A 1 84  ? 2.90794   -30.56882 21.05195  1.000 17.55281 ? 1092 ARG A NH1   1 
ATOM   653  N NH2   . ARG A 1 84  ? 1.36348   -28.87396 20.89691  1.000 16.15720 ? 1092 ARG A NH2   1 
ATOM   654  N N     . LEU A 1 85  ? 9.72832   -27.92960 17.47673  1.000 11.53407 ? 1093 LEU A N     1 
ATOM   655  C CA    . LEU A 1 85  ? 11.09819  -27.50765 17.18245  1.000 11.45333 ? 1093 LEU A CA    1 
ATOM   656  C C     . LEU A 1 85  ? 11.26177  -25.99306 17.30107  1.000 10.81582 ? 1093 LEU A C     1 
ATOM   657  O O     . LEU A 1 85  ? 10.36669  -25.21820 16.95631  1.000 11.74637 ? 1093 LEU A O     1 
ATOM   658  C CB    . LEU A 1 85  ? 11.49046  -27.95327 15.77623  1.000 12.51933 ? 1093 LEU A CB    1 
ATOM   659  C CG    . LEU A 1 85  ? 11.61887  -29.46353 15.58342  1.000 12.90819 ? 1093 LEU A CG    1 
ATOM   660  C CD1   . LEU A 1 85  ? 11.85292  -29.78500 14.10426  1.000 16.99177 ? 1093 LEU A CD1   1 
ATOM   661  C CD2   . LEU A 1 85  ? 12.76258  -30.00666 16.41914  1.000 16.13256 ? 1093 LEU A CD2   1 
ATOM   662  N N     . TYR A 1 86  ? 12.43210  -25.56615 17.78870  1.000 11.15443 ? 1094 TYR A N     1 
ATOM   663  C CA    . TYR A 1 86  ? 12.74815  -24.14060 17.91120  1.000 11.44276 ? 1094 TYR A CA    1 
ATOM   664  C C     . TYR A 1 86  ? 14.17659  -23.91438 17.43729  1.000 12.12738 ? 1094 TYR A C     1 
ATOM   665  O O     . TYR A 1 86  ? 15.10735  -24.54690 17.94761  1.000 11.61224 ? 1094 TYR A O     1 
ATOM   666  C CB    . TYR A 1 86  ? 12.57107  -23.65159 19.36266  1.000 11.89524 ? 1094 TYR A CB    1 
ATOM   667  C CG    . TYR A 1 86  ? 11.11766  -23.71295 19.77793  1.000 10.70811 ? 1094 TYR A CG    1 
ATOM   668  C CD1   . TYR A 1 86  ? 10.23563  -22.70176 19.41361  1.000 11.28920 ? 1094 TYR A CD1   1 
ATOM   669  C CD2   . TYR A 1 86  ? 10.62146  -24.82941 20.43944  1.000 11.14962 ? 1094 TYR A CD2   1 
ATOM   670  C CE1   . TYR A 1 86  ? 8.88380   -22.78796 19.71535  1.000 11.05277 ? 1094 TYR A CE1   1 
ATOM   671  C CE2   . TYR A 1 86  ? 9.26285   -24.93636 20.72703  1.000 12.94970 ? 1094 TYR A CE2   1 
ATOM   672  C CZ    . TYR A 1 86  ? 8.41281   -23.89657 20.37753  1.000 12.31433 ? 1094 TYR A CZ    1 
ATOM   673  O OH    . TYR A 1 86  ? 7.04803   -23.98123 20.65718  1.000 13.77968 ? 1094 TYR A OH    1 
ATOM   674  N N     . SER A 1 87  ? 14.34700  -23.01844 16.45932  1.000 10.98370 ? 1095 SER A N     1 
ATOM   675  C CA    . SER A 1 87  ? 15.68353  -22.64825 16.00156  1.000 9.85583  ? 1095 SER A CA    1 
ATOM   676  C C     . SER A 1 87  ? 16.49693  -22.11455 17.16307  1.000 9.76042  ? 1095 SER A C     1 
ATOM   677  O O     . SER A 1 87  ? 16.03883  -21.23165 17.89245  1.000 12.28218 ? 1095 SER A O     1 
ATOM   678  C CB    . SER A 1 87  ? 15.57546  -21.52526 14.97143  1.000 12.52014 ? 1095 SER A CB    1 
ATOM   679  O OG    . SER A 1 87  ? 14.89833  -21.93731 13.80092  1.000 14.29632 ? 1095 SER A OG    1 
ATOM   680  N N     . ILE A 1 88  ? 17.70896  -22.64147 17.33935  1.000 9.91699  ? 1096 ILE A N     1 
ATOM   681  C CA    . ILE A 1 88  ? 18.53570  -22.13060 18.42329  1.000 11.24036 ? 1096 ILE A CA    1 
ATOM   682  C C     . ILE A 1 88  ? 19.03646  -20.72836 18.06718  1.000 9.01094  ? 1096 ILE A C     1 
ATOM   683  O O     . ILE A 1 88  ? 19.53097  -20.47974 16.95667  1.000 11.22950 ? 1096 ILE A O     1 
ATOM   684  C CB    . ILE A 1 88  ? 19.64808  -23.12879 18.76381  1.000 10.55614 ? 1096 ILE A CB    1 
ATOM   685  C CG1   . ILE A 1 88  ? 19.01596  -24.45562 19.22960  1.000 11.89468 ? 1096 ILE A CG1   1 
ATOM   686  C CG2   . ILE A 1 88  ? 20.56320  -22.52851 19.81454  1.000 11.05391 ? 1096 ILE A CG2   1 
ATOM   687  C CD1   . ILE A 1 88  ? 19.94330  -25.67078 19.11267  1.000 12.89561 ? 1096 ILE A CD1   1 
ATOM   688  N N     . ALA A 1 89  ? 18.86597  -19.79282 18.99234  1.000 9.83315  ? 1097 ALA A N     1 
ATOM   689  C CA    . ALA A 1 89  ? 19.17113  -18.38796 18.78187  1.000 9.68235  ? 1097 ALA A CA    1 
ATOM   690  C C     . ALA A 1 89  ? 20.52915  -18.00214 19.34696  1.000 10.83597 ? 1097 ALA A C     1 
ATOM   691  O O     . ALA A 1 89  ? 20.90568  -16.83061 19.28785  1.000 10.85241 ? 1097 ALA A O     1 
ATOM   692  C CB    . ALA A 1 89  ? 18.06742  -17.51948 19.39670  1.000 10.96196 ? 1097 ALA A CB    1 
ATOM   693  N N     . SER A 1 90  ? 21.26309  -18.96649 19.90028  1.000 10.04589 ? 1098 SER A N     1 
ATOM   694  C CA    . SER A 1 90  ? 22.57515  -18.76650 20.48515  1.000 8.59813  ? 1098 SER A CA    1 
ATOM   695  C C     . SER A 1 90  ? 23.64174  -19.48720 19.67043  1.000 8.94631  ? 1098 SER A C     1 
ATOM   696  O O     . SER A 1 90  ? 23.36280  -20.36777 18.84985  1.000 10.15487 ? 1098 SER A O     1 
ATOM   697  C CB    . SER A 1 90  ? 22.56691  -19.33256 21.90695  1.000 11.04277 ? 1098 SER A CB    1 
ATOM   698  O OG    . SER A 1 90  ? 21.96315  -20.62368 21.93220  1.000 10.77454 ? 1098 SER A OG    1 
ATOM   699  N N     . THR A 1 91  ? 24.89274  -19.10525 19.92588  1.000 11.25905 ? 1099 THR A N     1 
ATOM   700  C CA    . THR A 1 91  ? 26.01808  -19.86516 19.39108  1.000 9.13558  ? 1099 THR A CA    1 
ATOM   701  C C     . THR A 1 91  ? 26.19454  -21.15359 20.18124  1.000 8.29833  ? 1099 THR A C     1 
ATOM   702  O O     . THR A 1 91  ? 25.57244  -21.35337 21.22610  1.000 9.63153  ? 1099 THR A O     1 
ATOM   703  C CB    . THR A 1 91  ? 27.32945  -19.09938 19.53181  1.000 10.39115 ? 1099 THR A CB    1 
ATOM   704  O OG1   . THR A 1 91  ? 27.70666  -19.10612 20.91729  1.000 10.35559 ? 1099 THR A OG1   1 
ATOM   705  C CG2   . THR A 1 91  ? 27.20794  -17.66861 19.03777  1.000 10.76623 ? 1099 THR A CG2   1 
ATOM   706  N N     . ARG A 1 92  ? 27.08451  -22.02210 19.68579  1.000 8.79469  ? 1100 ARG A N     1 
ATOM   707  C CA    . ARG A 1 92  ? 27.39914  -23.25899 20.40796  1.000 8.85710  ? 1100 ARG A CA    1 
ATOM   708  C C     . ARG A 1 92  ? 27.91700  -22.99290 21.81718  1.000 9.15384  ? 1100 ARG A C     1 
ATOM   709  O O     . ARG A 1 92  ? 27.78244  -23.86206 22.68817  1.000 10.62727 ? 1100 ARG A O     1 
ATOM   710  C CB    . ARG A 1 92  ? 28.38793  -24.10107 19.60510  1.000 10.48450 ? 1100 ARG A CB    1 
ATOM   711  C CG    . ARG A 1 92  ? 29.80797  -23.53114 19.53811  1.000 10.68752 ? 1100 ARG A CG    1 
ATOM   712  C CD    . ARG A 1 92  ? 30.66306  -24.37189 18.61571  1.000 11.44250 ? 1100 ARG A CD    1 
ATOM   713  N NE    . ARG A 1 92  ? 30.22920  -24.20289 17.23072  1.000 10.90799 ? 1100 ARG A NE    1 
ATOM   714  C CZ    . ARG A 1 92  ? 30.65858  -24.95884 16.23387  1.000 11.99255 ? 1100 ARG A CZ    1 
ATOM   715  N NH1   . ARG A 1 92  ? 31.49913  -25.95923 16.44546  1.000 14.10546 ? 1100 ARG A NH1   1 
ATOM   716  N NH2   . ARG A 1 92  ? 30.24726  -24.69241 14.99118  1.000 13.68826 ? 1100 ARG A NH2   1 
ATOM   717  N N     . TYR A 1 93  ? 28.50052  -21.81613 22.07156  1.000 10.26149 ? 1101 TYR A N     1 
ATOM   718  C CA    . TYR A 1 93  ? 28.95952  -21.46592 23.41583  1.000 9.55128  ? 1101 TYR A CA    1 
ATOM   719  C C     . TYR A 1 93  ? 27.83178  -20.90991 24.27554  1.000 10.36995 ? 1101 TYR A C     1 
ATOM   720  O O     . TYR A 1 93  ? 27.91760  -20.96602 25.51307  1.000 10.64592 ? 1101 TYR A O     1 
ATOM   721  C CB    . TYR A 1 93  ? 30.14115  -20.47955 23.32692  1.000 10.89647 ? 1101 TYR A CB    1 
ATOM   722  C CG    . TYR A 1 93  ? 31.28568  -21.08899 22.55097  1.000 11.93080 ? 1101 TYR A CG    1 
ATOM   723  C CD1   . TYR A 1 93  ? 32.14842  -22.01297 23.15231  1.000 10.82686 ? 1101 TYR A CD1   1 
ATOM   724  C CD2   . TYR A 1 93  ? 31.47482  -20.80515 21.20920  1.000 11.16720 ? 1101 TYR A CD2   1 
ATOM   725  C CE1   . TYR A 1 93  ? 33.17143  -22.61864 22.44344  1.000 11.78151 ? 1101 TYR A CE1   1 
ATOM   726  C CE2   . TYR A 1 93  ? 32.49415  -21.41457 20.48884  1.000 10.99734 ? 1101 TYR A CE2   1 
ATOM   727  C CZ    . TYR A 1 93  ? 33.33735  -22.31831 21.12249  1.000 11.72622 ? 1101 TYR A CZ    1 
ATOM   728  O OH    . TYR A 1 93  ? 34.34478  -22.93586 20.41665  1.000 14.02153 ? 1101 TYR A OH    1 
ATOM   729  N N     . GLY A 1 94  ? 26.78227  -20.36350 23.65450  1.000 10.45794 ? 1102 GLY A N     1 
ATOM   730  C CA    . GLY A 1 94  ? 25.64579  -19.84085 24.38430  1.000 10.04107 ? 1102 GLY A CA    1 
ATOM   731  C C     . GLY A 1 94  ? 25.90025  -18.46665 24.97463  1.000 9.17135  ? 1102 GLY A C     1 
ATOM   732  O O     . GLY A 1 94  ? 26.99808  -17.90551 24.91752  1.000 10.40794 ? 1102 GLY A O     1 
ATOM   733  N N     . ASP A 1 95  ? 24.84087  -17.91020 25.56350  1.000 10.52086 ? 1103 ASP A N     1 
ATOM   734  C CA    . ASP A 1 95  ? 24.86328  -16.50910 25.97684  1.000 10.92556 ? 1103 ASP A CA    1 
ATOM   735  C C     . ASP A 1 95  ? 25.78835  -16.25818 27.16166  1.000 10.62915 ? 1103 ASP A C     1 
ATOM   736  O O     . ASP A 1 95  ? 26.06899  -15.09101 27.46969  1.000 12.78558 ? 1103 ASP A O     1 
ATOM   737  C CB    . ASP A 1 95  ? 23.44512  -16.02106 26.31839  1.000 11.58794 ? 1103 ASP A CB    1 
ATOM   738  C CG    . ASP A 1 95  ? 22.51305  -15.97468 25.10545  1.000 11.06691 ? 1103 ASP A CG    1 
ATOM   739  O OD1   . ASP A 1 95  ? 22.98170  -16.08411 23.95651  1.000 10.77701 ? 1103 ASP A OD1   1 
ATOM   740  O OD2   . ASP A 1 95  ? 21.29137  -15.85030 25.36384  1.000 12.53964 ? 1103 ASP A OD2   1 
ATOM   741  N N     . ASN A 1 96  ? 26.22824  -17.31833 27.83769  1.000 10.81312 ? 1104 ASN A N     1 
ATOM   742  C CA    A ASN A 1 96  ? 27.16480  -17.25081 28.94396  0.304 11.88695 ? 1104 ASN A CA    1 
ATOM   743  C CA    B ASN A 1 96  ? 27.18361  -17.17770 28.92651  0.696 11.80811 ? 1104 ASN A CA    1 
ATOM   744  C C     . ASN A 1 96  ? 28.58387  -17.61395 28.51948  1.000 11.96727 ? 1104 ASN A C     1 
ATOM   745  O O     . ASN A 1 96  ? 29.47887  -17.65771 29.36642  1.000 13.16677 ? 1104 ASN A O     1 
ATOM   746  C CB    A ASN A 1 96  ? 26.65096  -18.16604 30.06521  0.304 13.65813 ? 1104 ASN A CB    1 
ATOM   747  C CB    B ASN A 1 96  ? 26.70502  -17.91044 30.18938  0.696 12.54792 ? 1104 ASN A CB    1 
ATOM   748  C CG    A ASN A 1 96  ? 27.13815  -17.76610 31.43352  0.304 17.50480 ? 1104 ASN A CG    1 
ATOM   749  C CG    B ASN A 1 96  ? 25.46659  -17.26373 30.81263  0.696 18.13533 ? 1104 ASN A CG    1 
ATOM   750  O OD1   A ASN A 1 96  ? 27.53706  -18.61458 32.22678  0.304 23.47324 ? 1104 ASN A OD1   1 
ATOM   751  O OD1   B ASN A 1 96  ? 25.15610  -16.10421 30.54873  0.696 22.72814 ? 1104 ASN A OD1   1 
ATOM   752  N ND2   A ASN A 1 96  ? 27.14377  -16.47119 31.70864  0.304 16.70547 ? 1104 ASN A ND2   1 
ATOM   753  N ND2   B ASN A 1 96  ? 24.76254  -18.01762 31.65046  0.696 21.03816 ? 1104 ASN A ND2   1 
ATOM   754  N N     . PHE A 1 97  ? 28.80527  -17.89555 27.23612  1.000 11.51308 ? 1105 PHE A N     1 
ATOM   755  C CA    . PHE A 1 97  ? 30.14342  -18.08888 26.66986  1.000 10.66413 ? 1105 PHE A CA    1 
ATOM   756  C C     . PHE A 1 97  ? 30.86776  -19.28462 27.28549  1.000 13.22798 ? 1105 PHE A C     1 
ATOM   757  O O     . PHE A 1 97  ? 32.10287  -19.31898 27.30969  1.000 12.66539 ? 1105 PHE A O     1 
ATOM   758  C CB    . PHE A 1 97  ? 30.98162  -16.80063 26.76868  1.000 11.46417 ? 1105 PHE A CB    1 
ATOM   759  C CG    . PHE A 1 97  ? 30.27068  -15.56421 26.24801  1.000 11.30474 ? 1105 PHE A CG    1 
ATOM   760  C CD1   . PHE A 1 97  ? 30.11658  -15.34937 24.87657  1.000 13.55345 ? 1105 PHE A CD1   1 
ATOM   761  C CD2   . PHE A 1 97  ? 29.76256  -14.62703 27.12649  1.000 12.19822 ? 1105 PHE A CD2   1 
ATOM   762  C CE1   . PHE A 1 97  ? 29.46619  -14.20667 24.39539  1.000 13.15806 ? 1105 PHE A CE1   1 
ATOM   763  C CE2   . PHE A 1 97  ? 29.10667  -13.48681 26.65255  1.000 14.82253 ? 1105 PHE A CE2   1 
ATOM   764  C CZ    . PHE A 1 97  ? 28.96409  -13.27710 25.28553  1.000 13.98802 ? 1105 PHE A CZ    1 
ATOM   765  N N     . ASP A 1 98  ? 30.10617  -20.29479 27.73384  1.000 10.97318 ? 1106 ASP A N     1 
ATOM   766  C CA    . ASP A 1 98  ? 30.65396  -21.40736 28.51234  1.000 10.33217 ? 1106 ASP A CA    1 
ATOM   767  C C     . ASP A 1 98  ? 30.23896  -22.78539 28.01763  1.000 10.58839 ? 1106 ASP A C     1 
ATOM   768  O O     . ASP A 1 98  ? 30.59048  -23.78600 28.64883  1.000 11.76197 ? 1106 ASP A O     1 
ATOM   769  C CB    . ASP A 1 98  ? 30.27942  -21.25812 30.00030  1.000 11.85708 ? 1106 ASP A CB    1 
ATOM   770  C CG    . ASP A 1 98  ? 28.76920  -21.32625 30.24234  1.000 12.59074 ? 1106 ASP A CG    1 
ATOM   771  O OD1   . ASP A 1 98  ? 27.98097  -21.50563 29.27569  1.000 12.00301 ? 1106 ASP A OD1   1 
ATOM   772  O OD2   . ASP A 1 98  ? 28.36774  -21.18762 31.42364  1.000 14.54902 ? 1106 ASP A OD2   1 
ATOM   773  N N     . GLY A 1 99  ? 29.49006  -22.87503 26.91795  1.000 9.80356  ? 1107 GLY A N     1 
ATOM   774  C CA    . GLY A 1 99  ? 29.08007  -24.18206 26.44253  1.000 10.45119 ? 1107 GLY A CA    1 
ATOM   775  C C     . GLY A 1 99  ? 28.02520  -24.88533 27.27325  1.000 9.70482  ? 1107 GLY A C     1 
ATOM   776  O O     . GLY A 1 99  ? 27.78703  -26.07861 27.05332  1.000 11.69693 ? 1107 GLY A O     1 
ATOM   777  N N     . ARG A 1 100 ? 27.37137  -24.17603 28.19839  1.000 10.64663 ? 1108 ARG A N     1 
ATOM   778  C CA    . ARG A 1 100 ? 26.40723  -24.79766 29.10199  1.000 11.68500 ? 1108 ARG A CA    1 
ATOM   779  C C     . ARG A 1 100 ? 24.96617  -24.39534 28.84542  1.000 12.74234 ? 1108 ARG A C     1 
ATOM   780  O O     . ARG A 1 100 ? 24.06600  -25.02549 29.40629  1.000 13.43301 ? 1108 ARG A O     1 
ATOM   781  C CB    . ARG A 1 100 ? 26.71531  -24.43166 30.56139  1.000 14.34981 ? 1108 ARG A CB    1 
ATOM   782  C CG    . ARG A 1 100 ? 27.98762  -25.03574 31.13916  1.000 18.99372 ? 1108 ARG A CG    1 
ATOM   783  C CD    . ARG A 1 100 ? 27.96979  -25.06854 32.69514  1.000 24.51885 ? 1108 ARG A CD    1 
ATOM   784  N NE    . ARG A 1 100 ? 26.70403  -25.58256 33.22109  1.000 32.70434 ? 1108 ARG A NE    1 
ATOM   785  C CZ    . ARG A 1 100 ? 26.58493  -26.39453 34.26657  1.000 37.74446 ? 1108 ARG A CZ    1 
ATOM   786  N NH1   . ARG A 1 100 ? 27.64427  -26.84278 34.92424  1.000 27.23644 ? 1108 ARG A NH1   1 
ATOM   787  N NH2   . ARG A 1 100 ? 25.37183  -26.78862 34.64871  1.000 34.36975 ? 1108 ARG A NH2   1 
ATOM   788  N N     . THR A 1 101 ? 24.71529  -23.34542 28.07372  1.000 10.66101 ? 1109 THR A N     1 
ATOM   789  C CA    . THR A 1 101 ? 23.34634  -22.90020 27.84191  1.000 11.40327 ? 1109 THR A CA    1 
ATOM   790  C C     . THR A 1 101 ? 23.09401  -22.70010 26.36079  1.000 10.93312 ? 1109 THR A C     1 
ATOM   791  O O     . THR A 1 101 ? 24.02248  -22.42594 25.58670  1.000 11.36835 ? 1109 THR A O     1 
ATOM   792  C CB    . THR A 1 101 ? 22.99272  -21.59028 28.57646  1.000 11.83100 ? 1109 THR A CB    1 
ATOM   793  O OG1   . THR A 1 101 ? 23.50467  -20.44637 27.87080  1.000 11.75165 ? 1109 THR A OG1   1 
ATOM   794  C CG2   . THR A 1 101 ? 23.47822  -21.60993 30.03456  1.000 13.41610 ? 1109 THR A CG2   1 
ATOM   795  N N     . GLY A 1 102 ? 21.81942  -22.86184 25.97700  1.000 10.88040 ? 1110 GLY A N     1 
ATOM   796  C CA    . GLY A 1 102 ? 21.35942  -22.45985 24.66737  1.000 10.08884 ? 1110 GLY A CA    1 
ATOM   797  C C     . GLY A 1 102 ? 20.09640  -21.63817 24.83441  1.000 10.16411 ? 1110 GLY A C     1 
ATOM   798  O O     . GLY A 1 102 ? 19.43515  -21.68546 25.88318  1.000 11.93649 ? 1110 GLY A O     1 
ATOM   799  N N     . SER A 1 103 ? 19.78505  -20.85068 23.80352  1.000 10.26415 ? 1111 SER A N     1 
ATOM   800  C CA    . SER A 1 103 ? 18.69510  -19.88933 23.89554  1.000 9.74466  ? 1111 SER A CA    1 
ATOM   801  C C     . SER A 1 103 ? 17.70763  -20.07827 22.75203  1.000 10.50993 ? 1111 SER A C     1 
ATOM   802  O O     . SER A 1 103 ? 18.09417  -20.41817 21.62813  1.000 10.95337 ? 1111 SER A O     1 
ATOM   803  C CB    . SER A 1 103 ? 19.21123  -18.45208 23.91543  1.000 9.82009  ? 1111 SER A CB    1 
ATOM   804  O OG    . SER A 1 103 ? 20.02899  -18.22293 25.06192  1.000 10.78233 ? 1111 SER A OG    1 
ATOM   805  N N     . LEU A 1 104 ? 16.42722  -19.80184 23.05349  1.000 9.85197  ? 1112 LEU A N     1 
ATOM   806  C CA    . LEU A 1 104 ? 15.34616  -19.84341 22.07775  1.000 8.81935  ? 1112 LEU A CA    1 
ATOM   807  C C     . LEU A 1 104 ? 14.68797  -18.46944 21.99663  1.000 9.98081  ? 1112 LEU A C     1 
ATOM   808  O O     . LEU A 1 104 ? 14.67069  -17.70156 22.96248  1.000 11.37032 ? 1112 LEU A O     1 
ATOM   809  C CB    . LEU A 1 104 ? 14.27145  -20.87909 22.47062  1.000 11.77506 ? 1112 LEU A CB    1 
ATOM   810  C CG    . LEU A 1 104 ? 14.77855  -22.30161 22.73121  1.000 10.63156 ? 1112 LEU A CG    1 
ATOM   811  C CD1   . LEU A 1 104 ? 13.59500  -23.21390 23.08432  1.000 14.33644 ? 1112 LEU A CD1   1 
ATOM   812  C CD2   . LEU A 1 104 ? 15.57001  -22.84713 21.53561  1.000 11.84257 ? 1112 LEU A CD2   1 
ATOM   813  N N     . CYS A 1 105 ? 14.13564  -18.17386 20.82166  1.000 10.16295 ? 1113 CYS A N     1 
ATOM   814  C CA    . CYS A 1 105 ? 13.40072  -16.94590 20.53122  1.000 11.12488 ? 1113 CYS A CA    1 
ATOM   815  C C     . CYS A 1 105 ? 11.98042  -17.36730 20.16574  1.000 10.39114 ? 1113 CYS A C     1 
ATOM   816  O O     . CYS A 1 105 ? 11.73567  -17.85542 19.05866  1.000 12.31425 ? 1113 CYS A O     1 
ATOM   817  C CB    . CYS A 1 105 ? 14.08864  -16.20926 19.39249  1.000 12.86401 ? 1113 CYS A CB    1 
ATOM   818  S SG    . CYS A 1 105 ? 13.23433  -14.71141 18.82581  1.000 12.06303 ? 1113 CYS A SG    1 
ATOM   819  N N     . VAL A 1 106 ? 11.05322  -17.21802 21.11974  1.000 11.20631 ? 1114 VAL A N     1 
ATOM   820  C CA    . VAL A 1 106 ? 9.74906   -17.89340 21.07435  1.000 11.73397 ? 1114 VAL A CA    1 
ATOM   821  C C     . VAL A 1 106 ? 8.61644   -16.86609 21.03807  1.000 12.07132 ? 1114 VAL A C     1 
ATOM   822  O O     . VAL A 1 106 ? 8.45537   -16.07848 21.97793  1.000 12.00559 ? 1114 VAL A O     1 
ATOM   823  C CB    . VAL A 1 106 ? 9.57626   -18.84002 22.27749  1.000 10.64204 ? 1114 VAL A CB    1 
ATOM   824  C CG1   . VAL A 1 106 ? 8.20995   -19.55613 22.22464  1.000 13.52196 ? 1114 VAL A CG1   1 
ATOM   825  C CG2   . VAL A 1 106 ? 10.71637  -19.84259 22.34755  1.000 13.13615 ? 1114 VAL A CG2   1 
ATOM   826  N N     . ALA A 1 107 ? 7.80104   -16.90752 19.97336  1.000 11.80365 ? 1115 ALA A N     1 
ATOM   827  C CA    . ALA A 1 107 ? 6.57299   -16.10681 19.89780  1.000 11.59358 ? 1115 ALA A CA    1 
ATOM   828  C C     . ALA A 1 107 ? 5.39553   -16.85496 20.52454  1.000 10.75768 ? 1115 ALA A C     1 
ATOM   829  O O     . ALA A 1 107 ? 5.14343   -18.01694 20.19641  1.000 13.01993 ? 1115 ALA A O     1 
ATOM   830  C CB    . ALA A 1 107 ? 6.23503   -15.81898 18.42915  1.000 13.27435 ? 1115 ALA A CB    1 
ATOM   831  N N     . ARG A 1 108 ? 4.67692   -16.18418 21.42025  1.000 12.46682 ? 1116 ARG A N     1 
ATOM   832  C CA    . ARG A 1 108 ? 3.43924   -16.76232 21.95308  1.000 13.46422 ? 1116 ARG A CA    1 
ATOM   833  C C     . ARG A 1 108 ? 2.40551   -16.90199 20.84963  1.000 14.32906 ? 1116 ARG A C     1 
ATOM   834  O O     . ARG A 1 108 ? 2.07932   -15.92655 20.16162  1.000 22.38126 ? 1116 ARG A O     1 
ATOM   835  C CB    . ARG A 1 108 ? 2.82402   -15.82160 22.97161  1.000 17.88830 ? 1116 ARG A CB    1 
ATOM   836  C CG    . ARG A 1 108 ? 3.41280   -15.80837 24.32246  1.000 20.50017 ? 1116 ARG A CG    1 
ATOM   837  C CD    . ARG A 1 108 ? 2.42313   -15.12947 25.26654  1.000 21.49162 ? 1116 ARG A CD    1 
ATOM   838  N NE    . ARG A 1 108 ? 3.02903   -14.88777 26.56794  1.000 17.99277 ? 1116 ARG A NE    1 
ATOM   839  C CZ    . ARG A 1 108 ? 3.03527   -15.75243 27.57053  1.000 16.96613 ? 1116 ARG A CZ    1 
ATOM   840  N NH1   . ARG A 1 108 ? 2.39049   -16.90490 27.49644  1.000 15.81384 ? 1116 ARG A NH1   1 
ATOM   841  N NH2   . ARG A 1 108 ? 3.70194   -15.44704 28.67831  1.000 17.41795 ? 1116 ARG A NH2   1 
ATOM   842  N N     . ALA A 1 109 ? 1.88283   -18.10073 20.67157  1.000 13.93757 ? 1117 ALA A N     1 
ATOM   843  C CA    . ALA A 1 109 ? 0.77893   -18.31663 19.73811  1.000 15.37968 ? 1117 ALA A CA    1 
ATOM   844  C C     . ALA A 1 109 ? -0.52975  -18.15138 20.51362  1.000 16.14285 ? 1117 ALA A C     1 
ATOM   845  O O     . ALA A 1 109 ? -0.84819  -18.96466 21.39000  1.000 18.15582 ? 1117 ALA A O     1 
ATOM   846  C CB    . ALA A 1 109 ? 0.88785   -19.70166 19.11555  1.000 15.56749 ? 1117 ALA A CB    1 
ATOM   847  N N     . VAL A 1 110 ? -1.28497  -17.10109 20.20157  1.000 15.69496 ? 1118 VAL A N     1 
ATOM   848  C CA    . VAL A 1 110 ? -2.51242  -16.77806 20.92247  1.000 15.69329 ? 1118 VAL A CA    1 
ATOM   849  C C     . VAL A 1 110 ? -3.66595  -16.80678 19.92433  1.000 19.26244 ? 1118 VAL A C     1 
ATOM   850  O O     . VAL A 1 110 ? -3.52356  -16.33529 18.79191  1.000 22.12264 ? 1118 VAL A O     1 
ATOM   851  C CB    . VAL A 1 110 ? -2.39836  -15.39202 21.58426  1.000 18.88894 ? 1118 VAL A CB    1 
ATOM   852  C CG1   . VAL A 1 110 ? -3.72266  -14.98213 22.23749  1.000 20.89599 ? 1118 VAL A CG1   1 
ATOM   853  C CG2   . VAL A 1 110 ? -1.25868  -15.37569 22.60195  1.000 21.73521 ? 1118 VAL A CG2   1 
ATOM   854  N N     . TYR A 1 111 ? -4.81045  -17.34671 20.34772  1.000 16.62084 ? 1119 TYR A N     1 
ATOM   855  C CA    . TYR A 1 111 ? -6.00126  -17.42953 19.50016  1.000 17.71565 ? 1119 TYR A CA    1 
ATOM   856  C C     . TYR A 1 111 ? -6.97071  -16.29840 19.82506  1.000 17.96163 ? 1119 TYR A C     1 
ATOM   857  O O     . TYR A 1 111 ? -7.37805  -16.14264 20.98186  1.000 17.54509 ? 1119 TYR A O     1 
ATOM   858  C CB    . TYR A 1 111 ? -6.73549  -18.75660 19.70438  1.000 17.30580 ? 1119 TYR A CB    1 
ATOM   859  C CG    . TYR A 1 111 ? -8.00159  -18.86596 18.87019  1.000 19.40635 ? 1119 TYR A CG    1 
ATOM   860  C CD1   . TYR A 1 111 ? -7.96464  -19.37572 17.58346  1.000 21.11275 ? 1119 TYR A CD1   1 
ATOM   861  C CD2   . TYR A 1 111 ? -9.22788  -18.42768 19.37022  1.000 17.03553 ? 1119 TYR A CD2   1 
ATOM   862  C CE1   . TYR A 1 111 ? -9.11677  -19.46555 16.81310  1.000 23.59670 ? 1119 TYR A CE1   1 
ATOM   863  C CE2   . TYR A 1 111 ? -10.37735 -18.49615 18.60407  1.000 18.40704 ? 1119 TYR A CE2   1 
ATOM   864  C CZ    . TYR A 1 111 ? -10.31436 -19.02321 17.33566  1.000 22.12137 ? 1119 TYR A CZ    1 
ATOM   865  O OH    . TYR A 1 111 ? -11.47010 -19.10105 16.58470  1.000 28.51233 ? 1119 TYR A OH    1 
ATOM   866  N N     . TYR A 1 112 ? -7.38017  -15.54742 18.79620  1.000 16.90553 ? 1120 TYR A N     1 
ATOM   867  C CA    . TYR A 1 112 ? -8.46148  -14.57100 18.89744  1.000 18.94621 ? 1120 TYR A CA    1 
ATOM   868  C C     . TYR A 1 112 ? -9.55443  -14.92768 17.90246  1.000 19.02054 ? 1120 TYR A C     1 
ATOM   869  O O     . TYR A 1 112 ? -9.26489  -15.22365 16.73724  1.000 19.95223 ? 1120 TYR A O     1 
ATOM   870  C CB    . TYR A 1 112 ? -7.97956  -13.14713 18.60246  1.000 20.68805 ? 1120 TYR A CB    1 
ATOM   871  C CG    . TYR A 1 112 ? -6.84783  -12.69889 19.48184  1.000 20.37985 ? 1120 TYR A CG    1 
ATOM   872  C CD1   . TYR A 1 112 ? -5.53147  -12.81958 19.05517  1.000 22.53767 ? 1120 TYR A CD1   1 
ATOM   873  C CD2   . TYR A 1 112 ? -7.09374  -12.13712 20.72243  1.000 27.12336 ? 1120 TYR A CD2   1 
ATOM   874  C CE1   . TYR A 1 112 ? -4.48422  -12.40421 19.85382  1.000 24.92268 ? 1120 TYR A CE1   1 
ATOM   875  C CE2   . TYR A 1 112 ? -6.05266  -11.71991 21.53380  1.000 30.12596 ? 1120 TYR A CE2   1 
ATOM   876  C CZ    . TYR A 1 112 ? -4.75057  -11.85888 21.08507  1.000 25.03549 ? 1120 TYR A CZ    1 
ATOM   877  O OH    . TYR A 1 112 ? -3.70595  -11.44198 21.88544  1.000 30.62696 ? 1120 TYR A OH    1 
ATOM   878  N N     . ASP A 1 113 ? -10.80827 -14.90424 18.35806  1.000 17.89544 ? 1121 ASP A N     1 
ATOM   879  C CA    . ASP A 1 113 ? -11.90794 -15.15096 17.42948  1.000 15.56699 ? 1121 ASP A CA    1 
ATOM   880  C C     . ASP A 1 113 ? -11.86408 -14.11179 16.31034  1.000 19.74470 ? 1121 ASP A C     1 
ATOM   881  O O     . ASP A 1 113 ? -11.73798 -12.91269 16.59258  1.000 22.57436 ? 1121 ASP A O     1 
ATOM   882  C CB    . ASP A 1 113 ? -13.25277 -15.08615 18.14576  1.000 18.87253 ? 1121 ASP A CB    1 
ATOM   883  C CG    . ASP A 1 113 ? -14.41643 -15.36522 17.20618  1.000 17.65110 ? 1121 ASP A CG    1 
ATOM   884  O OD1   . ASP A 1 113 ? -14.74638 -16.55425 17.00602  1.000 18.40064 ? 1121 ASP A OD1   1 
ATOM   885  O OD2   . ASP A 1 113 ? -14.98051 -14.39213 16.65998  1.000 22.28809 ? 1121 ASP A OD2   1 
ATOM   886  N N     . PRO A 1 114 ? -11.95946 -14.52476 15.04420  1.000 21.35891 ? 1122 PRO A N     1 
ATOM   887  C CA    . PRO A 1 114 ? -11.84693 -13.55278 13.94090  1.000 26.43273 ? 1122 PRO A CA    1 
ATOM   888  C C     . PRO A 1 114 ? -12.92726 -12.48279 13.92772  1.000 29.23142 ? 1122 PRO A C     1 
ATOM   889  O O     . PRO A 1 114 ? -12.69911 -11.40902 13.35908  1.000 34.16966 ? 1122 PRO A O     1 
ATOM   890  C CB    . PRO A 1 114 ? -11.91908 -14.43421 12.68875  1.000 27.44252 ? 1122 PRO A CB    1 
ATOM   891  C CG    . PRO A 1 114 ? -11.49007 -15.78047 13.15295  1.000 33.98726 ? 1122 PRO A CG    1 
ATOM   892  C CD    . PRO A 1 114 ? -12.03479 -15.90452 14.54348  1.000 21.08495 ? 1122 PRO A CD    1 
ATOM   893  N N     . GLU A 1 115 ? -14.09215 -12.72906 14.52313  1.000 28.59880 ? 1123 GLU A N     1 
ATOM   894  C CA    . GLU A 1 115 ? -15.18953 -11.76772 14.48841  1.000 28.22489 ? 1123 GLU A CA    1 
ATOM   895  C C     . GLU A 1 115 ? -15.23989 -10.87223 15.71861  1.000 32.63615 ? 1123 GLU A C     1 
ATOM   896  O O     . GLU A 1 115 ? -15.36893 -9.65077  15.59298  1.000 35.42968 ? 1123 GLU A O     1 
ATOM   897  C CB    . GLU A 1 115 ? -16.52977 -12.49783 14.32822  1.000 28.89490 ? 1123 GLU A CB    1 
ATOM   898  C CG    . GLU A 1 115 ? -17.72902 -11.56945 14.39930  1.000 40.79054 ? 1123 GLU A CG    1 
ATOM   899  C CD    . GLU A 1 115 ? -18.19234 -11.11584 13.03211  1.000 53.42786 ? 1123 GLU A CD    1 
ATOM   900  O OE1   . GLU A 1 115 ? -17.52059 -10.24957 12.42939  1.000 54.46339 ? 1123 GLU A OE1   1 
ATOM   901  O OE2   . GLU A 1 115 ? -19.23742 -11.61547 12.56768  1.000 55.49840 ? 1123 GLU A OE2   1 
ATOM   902  N N     . THR A 1 116 ? -15.16337 -11.45543 16.90954  1.000 25.14033 ? 1124 THR A N     1 
ATOM   903  C CA    . THR A 1 116 ? -15.31878 -10.69560 18.13974  1.000 25.17856 ? 1124 THR A CA    1 
ATOM   904  C C     . THR A 1 116 ? -13.99076 -10.23027 18.70586  1.000 24.27024 ? 1124 THR A C     1 
ATOM   905  O O     . THR A 1 116 ? -13.97563 -9.33958  19.56435  1.000 29.10675 ? 1124 THR A O     1 
ATOM   906  C CB    . THR A 1 116 ? -15.98648 -11.55687 19.21550  1.000 32.89454 ? 1124 THR A CB    1 
ATOM   907  O OG1   . THR A 1 116 ? -15.21321 -12.74711 19.41622  1.000 25.81089 ? 1124 THR A OG1   1 
ATOM   908  C CG2   . THR A 1 116 ? -17.40423 -11.94184 18.79352  1.000 35.44513 ? 1124 THR A CG2   1 
ATOM   909  N N     . GLY A 1 117 ? -12.88713 -10.82799 18.26409  1.000 23.06254 ? 1125 GLY A N     1 
ATOM   910  C CA    . GLY A 1 117 ? -11.60200 -10.56152 18.87109  1.000 24.48966 ? 1125 GLY A CA    1 
ATOM   911  C C     . GLY A 1 117 ? -11.38543 -11.22550 20.20926  1.000 24.76203 ? 1125 GLY A C     1 
ATOM   912  O O     . GLY A 1 117 ? -10.35342 -10.98270 20.84222  1.000 25.08528 ? 1125 GLY A O     1 
ATOM   913  N N     . LYS A 1 118 ? -12.32225 -12.05781 20.66390  1.000 24.36517 ? 1126 LYS A N     1 
ATOM   914  C CA    . LYS A 1 118 ? -12.21297 -12.65749 21.98729  1.000 28.02846 ? 1126 LYS A CA    1 
ATOM   915  C C     . LYS A 1 118 ? -11.09187 -13.68923 22.02376  1.000 17.97538 ? 1126 LYS A C     1 
ATOM   916  O O     . LYS A 1 118 ? -11.02281 -14.58177 21.17203  1.000 19.50024 ? 1126 LYS A O     1 
ATOM   917  C CB    . LYS A 1 118 ? -13.53639 -13.32164 22.37831  1.000 32.82693 ? 1126 LYS A CB    1 
ATOM   918  C CG    . LYS A 1 118 ? -14.66344 -12.34392 22.68305  1.000 42.10948 ? 1126 LYS A CG    1 
ATOM   919  C CD    . LYS A 1 118 ? -15.97350 -13.05815 23.02350  1.000 49.65845 ? 1126 LYS A CD    1 
ATOM   920  C CE    . LYS A 1 118 ? -15.75550 -14.45033 23.60572  1.000 49.13921 ? 1126 LYS A CE    1 
ATOM   921  N NZ    . LYS A 1 118 ? -15.74423 -14.43331 25.09701  1.000 50.57281 ? 1126 LYS A NZ    1 
ATOM   922  N N     . GLU A 1 119 ? -10.22105 -13.56885 23.02109  1.000 21.54981 ? 1127 GLU A N     1 
ATOM   923  C CA    . GLU A 1 119 ? -9.19344  -14.57590 23.21412  1.000 22.79091 ? 1127 GLU A CA    1 
ATOM   924  C C     . GLU A 1 119 ? -9.82249  -15.83364 23.79104  1.000 21.10347 ? 1127 GLU A C     1 
ATOM   925  O O     . GLU A 1 119 ? -10.77191 -15.77499 24.57573  1.000 24.87162 ? 1127 GLU A O     1 
ATOM   926  C CB    . GLU A 1 119 ? -8.10908  -14.06923 24.16999  1.000 22.58740 ? 1127 GLU A CB    1 
ATOM   927  C CG    . GLU A 1 119 ? -6.82258  -14.90053 24.11759  1.000 29.02148 ? 1127 GLU A CG    1 
ATOM   928  C CD    . GLU A 1 119 ? -6.00481  -14.83116 25.39636  1.000 36.35545 ? 1127 GLU A CD    1 
ATOM   929  O OE1   . GLU A 1 119 ? -6.07494  -13.79309 26.09016  1.000 39.01050 ? 1127 GLU A OE1   1 
ATOM   930  O OE2   . GLU A 1 119 ? -5.26297  -15.80001 25.68264  1.000 37.04333 ? 1127 GLU A OE2   1 
ATOM   931  N N     . ASP A 1 120 ? -9.29692  -16.98073 23.37884  1.000 18.00568 ? 1128 ASP A N     1 
ATOM   932  C CA    . ASP A 1 120 ? -9.72795  -18.26980 23.91638  1.000 15.53864 ? 1128 ASP A CA    1 
ATOM   933  C C     . ASP A 1 120 ? -8.46460  -19.02240 24.30550  1.000 17.88568 ? 1128 ASP A C     1 
ATOM   934  O O     . ASP A 1 120 ? -7.81027  -19.63635 23.44221  1.000 15.78925 ? 1128 ASP A O     1 
ATOM   935  C CB    . ASP A 1 120 ? -10.54537 -19.05045 22.89222  1.000 15.70096 ? 1128 ASP A CB    1 
ATOM   936  C CG    . ASP A 1 120 ? -11.00697 -20.40271 23.41559  1.000 12.96022 ? 1128 ASP A CG    1 
ATOM   937  O OD1   . ASP A 1 120 ? -10.57579 -20.81086 24.51887  1.000 15.82197 ? 1128 ASP A OD1   1 
ATOM   938  O OD2   . ASP A 1 120 ? -11.81532 -21.05293 22.71837  1.000 14.85877 ? 1128 ASP A OD2   1 
ATOM   939  N N     . PRO A 1 121 ? -8.09413  -19.00497 25.58684  1.000 15.56911 ? 1129 PRO A N     1 
ATOM   940  C CA    . PRO A 1 121 ? -6.83471  -19.65355 25.99807  1.000 15.65700 ? 1129 PRO A CA    1 
ATOM   941  C C     . PRO A 1 121 ? -6.76206  -21.13882 25.68281  1.000 15.63276 ? 1129 PRO A C     1 
ATOM   942  O O     . PRO A 1 121 ? -5.66472  -21.66568 25.46007  1.000 17.15564 ? 1129 PRO A O     1 
ATOM   943  C CB    . PRO A 1 121 ? -6.80436  -19.38033 27.50872  1.000 16.27156 ? 1129 PRO A CB    1 
ATOM   944  C CG    . PRO A 1 121 ? -7.49235  -18.06198 27.61322  1.000 18.51549 ? 1129 PRO A CG    1 
ATOM   945  C CD    . PRO A 1 121 ? -8.69474  -18.26778 26.71212  1.000 17.03729 ? 1129 PRO A CD    1 
ATOM   946  N N     . SER A 1 122 ? -7.89490  -21.83973 25.63062  1.000 15.06653 ? 1130 SER A N     1 
ATOM   947  C CA    . SER A 1 122 ? -7.86645  -23.25674 25.28701  1.000 13.59027 ? 1130 SER A CA    1 
ATOM   948  C C     . SER A 1 122 ? -7.36341  -23.50318 23.86845  1.000 13.53195 ? 1130 SER A C     1 
ATOM   949  O O     . SER A 1 122 ? -6.98149  -24.63446 23.54662  1.000 16.49994 ? 1130 SER A O     1 
ATOM   950  C CB    . SER A 1 122 ? -9.25884  -23.86774 25.48180  1.000 14.60785 ? 1130 SER A CB    1 
ATOM   951  O OG    . SER A 1 122 ? -10.12345 -23.51995 24.40826  1.000 13.97757 ? 1130 SER A OG    1 
ATOM   952  N N     . LYS A 1 123 ? -7.37313  -22.48229 23.01357  1.000 14.63026 ? 1131 LYS A N     1 
ATOM   953  C CA    . LYS A 1 123 ? -6.90357  -22.60946 21.64229  1.000 14.81158 ? 1131 LYS A CA    1 
ATOM   954  C C     . LYS A 1 123 ? -5.53080  -21.98396 21.43895  1.000 16.10236 ? 1131 LYS A C     1 
ATOM   955  O O     . LYS A 1 123 ? -5.05109  -21.92420 20.29750  1.000 15.12002 ? 1131 LYS A O     1 
ATOM   956  C CB    . LYS A 1 123 ? -7.93855  -22.03760 20.67380  1.000 15.11957 ? 1131 LYS A CB    1 
ATOM   957  C CG    . LYS A 1 123 ? -9.26843  -22.77800 20.75307  1.000 17.53922 ? 1131 LYS A CG    1 
ATOM   958  C CD    . LYS A 1 123 ? -10.26198 -22.24470 19.75390  1.000 20.20362 ? 1131 LYS A CD    1 
ATOM   959  C CE    . LYS A 1 123 ? -11.52925 -23.08322 19.76508  1.000 19.60928 ? 1131 LYS A CE    1 
ATOM   960  N NZ    . LYS A 1 123 ? -12.60001 -22.40288 18.96304  1.000 19.23531 ? 1131 LYS A NZ    1 
ATOM   961  N N     A ASN A 1 124 ? -4.88787  -21.50948 22.50441  0.700 14.58546 ? 1132 ASN A N     1 
ATOM   962  N N     B ASN A 1 124 ? -4.88588  -21.54355 22.51638  0.300 14.53255 ? 1132 ASN A N     1 
ATOM   963  C CA    A ASN A 1 124 ? -3.54227  -20.96134 22.39229  0.700 16.70238 ? 1132 ASN A CA    1 
ATOM   964  C CA    B ASN A 1 124 ? -3.53746  -21.02119 22.41357  0.300 16.67006 ? 1132 ASN A CA    1 
ATOM   965  C C     A ASN A 1 124 ? -2.53017  -22.09072 22.16913  0.700 14.33944 ? 1132 ASN A C     1 
ATOM   966  C C     B ASN A 1 124 ? -2.57870  -22.13136 21.99215  0.300 14.65003 ? 1132 ASN A C     1 
ATOM   967  O O     A ASN A 1 124 ? -2.78325  -23.25734 22.47618  0.700 18.22823 ? 1132 ASN A O     1 
ATOM   968  O O     B ASN A 1 124 ? -2.91466  -23.31955 21.96323  0.300 13.43141 ? 1132 ASN A O     1 
ATOM   969  C CB    A ASN A 1 124 ? -3.17970  -20.18355 23.66641  0.700 15.42581 ? 1132 ASN A CB    1 
ATOM   970  C CB    B ASN A 1 124 ? -3.13169  -20.29834 23.70950  0.300 15.34440 ? 1132 ASN A CB    1 
ATOM   971  C CG    A ASN A 1 124 ? -3.92967  -18.83051 23.80309  0.700 15.74182 ? 1132 ASN A CG    1 
ATOM   972  C CG    B ASN A 1 124 ? -2.73866  -21.24218 24.86222  0.300 17.29632 ? 1132 ASN A CG    1 
ATOM   973  O OD1   A ASN A 1 124 ? -4.72161  -18.41804 22.93751  0.700 14.35228 ? 1132 ASN A OD1   1 
ATOM   974  O OD1   B ASN A 1 124 ? -2.76843  -22.46709 24.74982  0.300 17.14765 ? 1132 ASN A OD1   1 
ATOM   975  N ND2   A ASN A 1 124 ? -3.67821  -18.14521 24.91386  0.700 19.83017 ? 1132 ASN A ND2   1 
ATOM   976  N ND2   B ASN A 1 124 ? -2.40333  -20.64350 26.00237  0.300 18.67141 ? 1132 ASN A ND2   1 
ATOM   977  N N     . GLY A 1 125 ? -1.36518  -21.73035 21.62964  1.000 15.05736 ? 1133 GLY A N     1 
ATOM   978  C CA    . GLY A 1 125 ? -0.34291  -22.72443 21.33361  1.000 15.80604 ? 1133 GLY A CA    1 
ATOM   979  C C     . GLY A 1 125 ? 0.24335   -23.29093 22.62421  1.000 13.35967 ? 1133 GLY A C     1 
ATOM   980  O O     . GLY A 1 125 ? 0.64372   -22.53728 23.51606  1.000 14.62967 ? 1133 GLY A O     1 
ATOM   981  N N     . VAL A 1 126 ? 0.31671   -24.62046 22.71290  1.000 12.38422 ? 1134 VAL A N     1 
ATOM   982  C CA    . VAL A 1 126 ? 0.70265   -25.25987 23.97927  1.000 14.11017 ? 1134 VAL A CA    1 
ATOM   983  C C     . VAL A 1 126 ? 2.16830   -24.98577 24.31707  1.000 12.78973 ? 1134 VAL A C     1 
ATOM   984  O O     . VAL A 1 126 ? 2.49056   -24.47346 25.39964  1.000 13.80224 ? 1134 VAL A O     1 
ATOM   985  C CB    . VAL A 1 126 ? 0.40099   -26.76667 23.96224  1.000 14.07596 ? 1134 VAL A CB    1 
ATOM   986  C CG1   . VAL A 1 126 ? 0.93002   -27.42106 25.24719  1.000 16.47641 ? 1134 VAL A CG1   1 
ATOM   987  C CG2   . VAL A 1 126 ? -1.11258  -27.00451 23.82850  1.000 17.39250 ? 1134 VAL A CG2   1 
ATOM   988  N N     . CYS A 1 127 ? 3.08043   -25.33125 23.39981  1.000 12.21394 ? 1135 CYS A N     1 
ATOM   989  C CA    . CYS A 1 127 ? 4.50238   -25.26104 23.74404  1.000 13.37948 ? 1135 CYS A CA    1 
ATOM   990  C C     . CYS A 1 127 ? 5.00567   -23.82189 23.82658  1.000 12.32255 ? 1135 CYS A C     1 
ATOM   991  O O     . CYS A 1 127 ? 5.82371   -23.48722 24.70081  1.000 12.92037 ? 1135 CYS A O     1 
ATOM   992  C CB    . CYS A 1 127 ? 5.32780   -26.09408 22.76937  1.000 12.16528 ? 1135 CYS A CB    1 
ATOM   993  S SG    . CYS A 1 127 ? 6.95642   -26.50723 23.44760  1.000 12.57546 ? 1135 CYS A SG    1 
ATOM   994  N N     . SER A 1 128 ? 4.51815   -22.93894 22.95038  1.000 12.03708 ? 1136 SER A N     1 
ATOM   995  C CA    . SER A 1 128 ? 5.00917   -21.56520 22.96251  1.000 11.81518 ? 1136 SER A CA    1 
ATOM   996  C C     . SER A 1 128 ? 4.59137   -20.83745 24.23472  1.000 13.14930 ? 1136 SER A C     1 
ATOM   997  O O     . SER A 1 128 ? 5.39677   -20.11493 24.83662  1.000 13.35376 ? 1136 SER A O     1 
ATOM   998  C CB    . SER A 1 128 ? 4.54462   -20.80177 21.71588  1.000 12.57106 ? 1136 SER A CB    1 
ATOM   999  O OG    . SER A 1 128 ? 3.11240   -20.70651 21.65144  1.000 14.10375 ? 1136 SER A OG    1 
ATOM   1000 N N     . ASN A 1 129 ? 3.34044   -21.03195 24.67572  1.000 13.35644 ? 1137 ASN A N     1 
ATOM   1001 C CA    . ASN A 1 129 ? 2.92063   -20.47538 25.96201  1.000 14.38192 ? 1137 ASN A CA    1 
ATOM   1002 C C     . ASN A 1 129 ? 3.59463   -21.12691 27.15542  1.000 12.24056 ? 1137 ASN A C     1 
ATOM   1003 O O     . ASN A 1 129 ? 3.96765   -20.42690 28.10376  1.000 13.02364 ? 1137 ASN A O     1 
ATOM   1004 C CB    . ASN A 1 129 ? 1.40496   -20.27531 26.08917  1.000 15.55939 ? 1137 ASN A CB    1 
ATOM   1005 C CG    . ASN A 1 129 ? 0.85433   -19.40398 24.98058  1.000 16.56756 ? 1137 ASN A CG    1 
ATOM   1006 O OD1   . ASN A 1 129 ? 0.37038   -19.85734 23.93225  1.000 16.66285 ? 1137 ASN A OD1   1 
ATOM   1007 N ND2   . ASN A 1 129 ? 0.94766   -18.10080 25.21419  1.000 19.72711 ? 1137 ASN A ND2   1 
ATOM   1008 N N     . PHE A 1 130 ? 3.77731   -22.44663 27.11443  1.000 13.11438 ? 1138 PHE A N     1 
ATOM   1009 C CA    . PHE A 1 130 ? 4.55058   -23.14017 28.14392  1.000 12.72828 ? 1138 PHE A CA    1 
ATOM   1010 C C     . PHE A 1 130 ? 5.92245   -22.49686 28.32325  1.000 11.85370 ? 1138 PHE A C     1 
ATOM   1011 O O     . PHE A 1 130 ? 6.33702   -22.16384 29.44256  1.000 12.61893 ? 1138 PHE A O     1 
ATOM   1012 C CB    . PHE A 1 130 ? 4.67381   -24.62377 27.76053  1.000 13.58268 ? 1138 PHE A CB    1 
ATOM   1013 C CG    . PHE A 1 130 ? 5.69679   -25.38835 28.56006  1.000 13.45571 ? 1138 PHE A CG    1 
ATOM   1014 C CD1   . PHE A 1 130 ? 5.52169   -25.58807 29.92263  1.000 12.81267 ? 1138 PHE A CD1   1 
ATOM   1015 C CD2   . PHE A 1 130 ? 6.83278   -25.90676 27.94588  1.000 13.94310 ? 1138 PHE A CD2   1 
ATOM   1016 C CE1   . PHE A 1 130 ? 6.47699   -26.29679 30.67078  1.000 13.53150 ? 1138 PHE A CE1   1 
ATOM   1017 C CE2   . PHE A 1 130 ? 7.79758   -26.61584 28.68279  1.000 13.36348 ? 1138 PHE A CE2   1 
ATOM   1018 C CZ    . PHE A 1 130 ? 7.60971   -26.82114 30.04038  1.000 13.68413 ? 1138 PHE A CZ    1 
ATOM   1019 N N     . LEU A 1 131 ? 6.63012   -22.27981 27.21217  1.000 12.58814 ? 1139 LEU A N     1 
ATOM   1020 C CA    . LEU A 1 131 ? 7.96475   -21.69092 27.27417  1.000 11.41119 ? 1139 LEU A CA    1 
ATOM   1021 C C     . LEU A 1 131 ? 7.92008   -20.24872 27.77217  1.000 11.64459 ? 1139 LEU A C     1 
ATOM   1022 O O     . LEU A 1 131 ? 8.66441   -19.86770 28.68530  1.000 11.78875 ? 1139 LEU A O     1 
ATOM   1023 C CB    . LEU A 1 131 ? 8.62539   -21.80039 25.89930  1.000 12.10367 ? 1139 LEU A CB    1 
ATOM   1024 C CG    . LEU A 1 131 ? 9.09824   -23.20594 25.50539  1.000 11.81039 ? 1139 LEU A CG    1 
ATOM   1025 C CD1   . LEU A 1 131 ? 9.47017   -23.27388 24.02068  1.000 13.98461 ? 1139 LEU A CD1   1 
ATOM   1026 C CD2   . LEU A 1 131 ? 10.28306  -23.61834 26.36462  1.000 14.24849 ? 1139 LEU A CD2   1 
ATOM   1027 N N     . CYS A 1 132 ? 7.02788   -19.42555 27.20890  1.000 11.53366 ? 1140 CYS A N     1 
ATOM   1028 C CA    . CYS A 1 132 ? 6.97037   -18.02589 27.62568  1.000 13.41610 ? 1140 CYS A CA    1 
ATOM   1029 C C     . CYS A 1 132 ? 6.45887   -17.83956 29.05064  1.000 11.96256 ? 1140 CYS A C     1 
ATOM   1030 O O     . CYS A 1 132 ? 6.73457   -16.79813 29.65933  1.000 13.16699 ? 1140 CYS A O     1 
ATOM   1031 C CB    . CYS A 1 132 ? 6.13180   -17.19206 26.63595  1.000 12.98099 ? 1140 CYS A CB    1 
ATOM   1032 S SG    . CYS A 1 132 ? 6.90375   -17.02201 25.00488  1.000 14.09268 ? 1140 CYS A SG    1 
ATOM   1033 N N     . ASN A 1 133 ? 5.73300   -18.82123 29.57872  1.000 12.34796 ? 1141 ASN A N     1 
ATOM   1034 C CA    . ASN A 1 133 ? 5.28240   -18.79657 30.96760  1.000 13.21853 ? 1141 ASN A CA    1 
ATOM   1035 C C     . ASN A 1 133 ? 6.31300   -19.36759 31.94064  1.000 12.86946 ? 1141 ASN A C     1 
ATOM   1036 O O     . ASN A 1 133 ? 6.07144   -19.34677 33.15257  1.000 12.81937 ? 1141 ASN A O     1 
ATOM   1037 C CB    . ASN A 1 133 ? 3.97882   -19.59680 31.10008  1.000 14.46311 ? 1141 ASN A CB    1 
ATOM   1038 C CG    . ASN A 1 133 ? 2.78589   -18.88839 30.47094  1.000 12.80180 ? 1141 ASN A CG    1 
ATOM   1039 O OD1   . ASN A 1 133 ? 2.78841   -17.67417 30.31577  1.000 14.32480 ? 1141 ASN A OD1   1 
ATOM   1040 N ND2   . ASN A 1 133 ? 1.77124   -19.66299 30.09048  1.000 17.40255 ? 1141 ASN A ND2   1 
ATOM   1041 N N     . SER A 1 134 ? 7.43780   -19.88128 31.44881  1.000 10.86300 ? 1142 SER A N     1 
ATOM   1042 C CA    . SER A 1 134 ? 8.41762   -20.53470 32.30712  1.000 10.04700 ? 1142 SER A CA    1 
ATOM   1043 C C     . SER A 1 134 ? 9.18517   -19.52707 33.16690  1.000 13.22753 ? 1142 SER A C     1 
ATOM   1044 O O     . SER A 1 134 ? 9.26426   -18.33897 32.86009  1.000 12.45724 ? 1142 SER A O     1 
ATOM   1045 C CB    . SER A 1 134 ? 9.39377   -21.33826 31.45547  1.000 12.58269 ? 1142 SER A CB    1 
ATOM   1046 O OG    . SER A 1 134 ? 8.76025   -22.44170 30.81557  1.000 12.95653 ? 1142 SER A OG    1 
ATOM   1047 N N     . LYS A 1 135 ? 9.74750   -20.03026 34.26647  1.000 11.94797 ? 1143 LYS A N     1 
ATOM   1048 C CA    . LYS A 1 135 ? 10.47384  -19.26834 35.27316  1.000 10.59715 ? 1143 LYS A CA    1 
ATOM   1049 C C     . LYS A 1 135 ? 11.78717  -19.96290 35.60701  1.000 12.25597 ? 1143 LYS A C     1 
ATOM   1050 O O     . LYS A 1 135 ? 11.93120  -21.17583 35.40533  1.000 11.04267 ? 1143 LYS A O     1 
ATOM   1051 C CB    . LYS A 1 135 ? 9.64231   -19.19158 36.56421  1.000 11.91723 ? 1143 LYS A CB    1 
ATOM   1052 C CG    . LYS A 1 135 ? 8.29597   -18.50233 36.39078  1.000 12.79734 ? 1143 LYS A CG    1 
ATOM   1053 C CD    . LYS A 1 135 ? 8.45549   -17.02020 36.08849  1.000 18.22506 ? 1143 LYS A CD    1 
ATOM   1054 C CE    . LYS A 1 135 ? 7.10308   -16.30695 36.09278  1.000 24.18094 ? 1143 LYS A CE    1 
ATOM   1055 N NZ    . LYS A 1 135 ? 7.24049   -14.86318 35.73283  1.000 30.89500 ? 1143 LYS A NZ    1 
ATOM   1056 N N     . PRO A 1 136 ? 12.76561  -19.21872 36.13397  1.000 12.80827 ? 1144 PRO A N     1 
ATOM   1057 C CA    . PRO A 1 136 ? 14.04083  -19.83783 36.52882  1.000 11.92645 ? 1144 PRO A CA    1 
ATOM   1058 C C     . PRO A 1 136 ? 13.82173  -21.06660 37.40456  1.000 11.73371 ? 1144 PRO A C     1 
ATOM   1059 O O     . PRO A 1 136 ? 13.00704  -21.05697 38.34529  1.000 12.79298 ? 1144 PRO A O     1 
ATOM   1060 C CB    . PRO A 1 136 ? 14.75373  -18.71114 37.28411  1.000 12.01553 ? 1144 PRO A CB    1 
ATOM   1061 C CG    . PRO A 1 136 ? 14.26135  -17.45810 36.59872  1.000 15.25001 ? 1144 PRO A CG    1 
ATOM   1062 C CD    . PRO A 1 136 ? 12.79930  -17.74939 36.26556  1.000 15.99251 ? 1144 PRO A CD    1 
ATOM   1063 N N     . GLY A 1 137 ? 14.55376  -22.13668 37.09337  1.000 11.43033 ? 1145 GLY A N     1 
ATOM   1064 C CA    . GLY A 1 137 ? 14.44957  -23.38510 37.81518  1.000 12.65915 ? 1145 GLY A CA    1 
ATOM   1065 C C     . GLY A 1 137 ? 13.44976  -24.37517 37.24329  1.000 11.07723 ? 1145 GLY A C     1 
ATOM   1066 O O     . GLY A 1 137 ? 13.51025  -25.55832 37.59095  1.000 12.82769 ? 1145 GLY A O     1 
ATOM   1067 N N     . ASP A 1 138 ? 12.52547  -23.93082 36.39062  1.000 10.20943 ? 1146 ASP A N     1 
ATOM   1068 C CA    . ASP A 1 138 ? 11.62109  -24.88698 35.76381  1.000 9.96070  ? 1146 ASP A CA    1 
ATOM   1069 C C     . ASP A 1 138 ? 12.39651  -25.86480 34.88162  1.000 10.21342 ? 1146 ASP A C     1 
ATOM   1070 O O     . ASP A 1 138 ? 13.44089  -25.53161 34.31146  1.000 11.14851 ? 1146 ASP A O     1 
ATOM   1071 C CB    . ASP A 1 138 ? 10.60003  -24.16023 34.88977  1.000 11.02998 ? 1146 ASP A CB    1 
ATOM   1072 C CG    . ASP A 1 138 ? 9.50392   -23.44667 35.68694  1.000 10.70259 ? 1146 ASP A CG    1 
ATOM   1073 O OD1   . ASP A 1 138 ? 9.35004   -23.67458 36.90269  1.000 11.66816 ? 1146 ASP A OD1   1 
ATOM   1074 O OD2   . ASP A 1 138 ? 8.75989   -22.65547 35.04213  1.000 11.59016 ? 1146 ASP A OD2   1 
ATOM   1075 N N     . LYS A 1 139 ? 11.86636  -27.07465 34.73935  1.000 11.84606 ? 1147 LYS A N     1 
ATOM   1076 C CA    . LYS A 1 139 ? 12.48985  -28.09057 33.90010  1.000 11.13377 ? 1147 LYS A CA    1 
ATOM   1077 C C     . LYS A 1 139 ? 11.86704  -28.09986 32.50588  1.000 13.53135 ? 1147 LYS A C     1 
ATOM   1078 O O     . LYS A 1 139 ? 10.66254  -27.87294 32.32880  1.000 13.84613 ? 1147 LYS A O     1 
ATOM   1079 C CB    . LYS A 1 139 ? 12.36389  -29.48948 34.51242  1.000 11.33798 ? 1147 LYS A CB    1 
ATOM   1080 C CG    . LYS A 1 139 ? 12.89543  -29.62851 35.94010  1.000 12.81258 ? 1147 LYS A CG    1 
ATOM   1081 C CD    . LYS A 1 139 ? 14.30701  -29.04402 36.05981  1.000 13.11727 ? 1147 LYS A CD    1 
ATOM   1082 C CE    . LYS A 1 139 ? 14.93450  -29.43393 37.37451  1.000 13.80736 ? 1147 LYS A CE    1 
ATOM   1083 N NZ    . LYS A 1 139 ? 16.16221  -28.63763 37.65847  1.000 14.51245 ? 1147 LYS A NZ    1 
ATOM   1084 N N     . ILE A 1 140 ? 12.70420  -28.39166 31.51244  1.000 12.64642 ? 1148 ILE A N     1 
ATOM   1085 C CA    . ILE A 1 140 ? 12.29983  -28.45018 30.10650  1.000 11.96009 ? 1148 ILE A CA    1 
ATOM   1086 C C     . ILE A 1 140 ? 12.80279  -29.77227 29.54201  1.000 13.94705 ? 1148 ILE A C     1 
ATOM   1087 O O     . ILE A 1 140 ? 13.99715  -30.08000 29.65397  1.000 14.86149 ? 1148 ILE A O     1 
ATOM   1088 C CB    . ILE A 1 140 ? 12.91912  -27.29214 29.29460  1.000 13.60886 ? 1148 ILE A CB    1 
ATOM   1089 C CG1   . ILE A 1 140 ? 12.56970  -25.93287 29.88665  1.000 17.92573 ? 1148 ILE A CG1   1 
ATOM   1090 C CG2   . ILE A 1 140 ? 12.46013  -27.35962 27.83221  1.000 16.15157 ? 1148 ILE A CG2   1 
ATOM   1091 C CD1   . ILE A 1 140 ? 11.08285  -25.63162 29.91581  1.000 18.01428 ? 1148 ILE A CD1   1 
ATOM   1092 N N     . GLN A 1 141 ? 11.90544  -30.54714 28.92251  1.000 12.66753 ? 1149 GLN A N     1 
ATOM   1093 C CA    A GLN A 1 141 ? 12.27687  -31.79659 28.26087  0.569 12.44081 ? 1149 GLN A CA    1 
ATOM   1094 C CA    B GLN A 1 141 ? 12.28784  -31.79289 28.26294  0.431 12.42690 ? 1149 GLN A CA    1 
ATOM   1095 C C     . GLN A 1 141 ? 12.81294  -31.47849 26.86748  1.000 12.38763 ? 1149 GLN A C     1 
ATOM   1096 O O     . GLN A 1 141 ? 12.04934  -31.09493 25.97298  1.000 13.57121 ? 1149 GLN A O     1 
ATOM   1097 C CB    A GLN A 1 141 ? 11.06419  -32.71917 28.17618  0.569 14.73676 ? 1149 GLN A CB    1 
ATOM   1098 C CB    B GLN A 1 141 ? 11.10725  -32.75469 28.20320  0.431 14.77414 ? 1149 GLN A CB    1 
ATOM   1099 C CG    A GLN A 1 141 ? 10.56401  -33.23980 29.52975  0.569 18.61318 ? 1149 GLN A CG    1 
ATOM   1100 C CG    B GLN A 1 141 ? 10.73681  -33.35412 29.55203  0.431 18.58847 ? 1149 GLN A CG    1 
ATOM   1101 C CD    A GLN A 1 141 ? 11.57363  -34.14189 30.22557  0.569 17.08890 ? 1149 GLN A CD    1 
ATOM   1102 C CD    B GLN A 1 141 ? 9.54298   -34.27582 29.45689  0.431 22.41228 ? 1149 GLN A CD    1 
ATOM   1103 O OE1   A GLN A 1 141 ? 12.36713  -33.68421 31.04050  0.569 21.49180 ? 1149 GLN A OE1   1 
ATOM   1104 O OE1   B GLN A 1 141 ? 8.68217   -34.10406 28.59189  0.431 27.06899 ? 1149 GLN A OE1   1 
ATOM   1105 N NE2   A GLN A 1 141 ? 11.54060  -35.43323 29.90835  0.569 19.74937 ? 1149 GLN A NE2   1 
ATOM   1106 N NE2   B GLN A 1 141 ? 9.49068   -35.27186 30.32981  0.431 26.46404 ? 1149 GLN A NE2   1 
ATOM   1107 N N     . LEU A 1 142 ? 14.11406  -31.65065 26.67647  1.000 11.12099 ? 1150 LEU A N     1 
ATOM   1108 C CA    . LEU A 1 142 ? 14.80002  -31.28108 25.45364  1.000 12.07667 ? 1150 LEU A CA    1 
ATOM   1109 C C     . LEU A 1 142 ? 15.14450  -32.51054 24.62108  1.000 11.86456 ? 1150 LEU A C     1 
ATOM   1110 O O     . LEU A 1 142 ? 15.62928  -33.52238 25.14161  1.000 12.57593 ? 1150 LEU A O     1 
ATOM   1111 C CB    . LEU A 1 142 ? 16.08811  -30.56537 25.86349  1.000 19.49311 ? 1150 LEU A CB    1 
ATOM   1112 C CG    . LEU A 1 142 ? 16.64959  -29.38429 25.09773  1.000 24.94444 ? 1150 LEU A CG    1 
ATOM   1113 C CD1   . LEU A 1 142 ? 15.63698  -28.24634 25.07018  1.000 16.61009 ? 1150 LEU A CD1   1 
ATOM   1114 C CD2   . LEU A 1 142 ? 17.91577  -28.96136 25.84712  1.000 14.95748 ? 1150 LEU A CD2   1 
ATOM   1115 N N     . THR A 1 143 ? 14.93006  -32.40391 23.30970  1.000 13.35718 ? 1151 THR A N     1 
ATOM   1116 C CA    . THR A 1 143 ? 15.37009  -33.43225 22.37798  1.000 12.88140 ? 1151 THR A CA    1 
ATOM   1117 C C     . THR A 1 143 ? 16.24265  -32.79973 21.29991  1.000 11.40030 ? 1151 THR A C     1 
ATOM   1118 O O     . THR A 1 143 ? 16.29817  -31.57593 21.13253  1.000 12.53098 ? 1151 THR A O     1 
ATOM   1119 C CB    . THR A 1 143 ? 14.20624  -34.19227 21.73188  1.000 13.82403 ? 1151 THR A CB    1 
ATOM   1120 O OG1   . THR A 1 143 ? 13.46170  -33.29366 20.90410  1.000 14.97595 ? 1151 THR A OG1   1 
ATOM   1121 C CG2   . THR A 1 143 ? 13.28402  -34.78532 22.79302  1.000 16.25489 ? 1151 THR A CG2   1 
ATOM   1122 N N     . GLY A 1 144 ? 16.92469  -33.66491 20.55828  1.000 12.29684 ? 1152 GLY A N     1 
ATOM   1123 C CA    . GLY A 1 144 ? 17.75381  -33.22521 19.45859  1.000 13.23826 ? 1152 GLY A CA    1 
ATOM   1124 C C     . GLY A 1 144 ? 19.21544  -33.19606 19.84394  1.000 11.73902 ? 1152 GLY A C     1 
ATOM   1125 O O     . GLY A 1 144 ? 19.68821  -34.04133 20.60899  1.000 13.26661 ? 1152 GLY A O     1 
ATOM   1126 N N     . PRO A 1 145 ? 19.98066  -32.23677 19.29535  1.000 12.15297 ? 1153 PRO A N     1 
ATOM   1127 C CA    . PRO A 1 145 ? 19.51670  -31.21308 18.34726  1.000 11.17301 ? 1153 PRO A CA    1 
ATOM   1128 C C     . PRO A 1 145 ? 19.18751  -31.82748 17.00278  1.000 12.71342 ? 1153 PRO A C     1 
ATOM   1129 O O     . PRO A 1 145 ? 19.47158  -33.00783 16.76040  1.000 13.75704 ? 1153 PRO A O     1 
ATOM   1130 C CB    . PRO A 1 145 ? 20.72911  -30.28530 18.20794  1.000 13.58654 ? 1153 PRO A CB    1 
ATOM   1131 C CG    . PRO A 1 145 ? 21.91440  -31.14921 18.47453  1.000 16.09687 ? 1153 PRO A CG    1 
ATOM   1132 C CD    . PRO A 1 145 ? 21.44773  -32.21527 19.46313  1.000 12.31429 ? 1153 PRO A CD    1 
ATOM   1133 N N     . SER A 1 146 ? 18.57447  -31.05358 16.12123  1.000 12.47639 ? 1154 SER A N     1 
ATOM   1134 C CA    . SER A 1 146 ? 18.28995  -31.60095 14.80739  1.000 14.92825 ? 1154 SER A CA    1 
ATOM   1135 C C     . SER A 1 146 ? 18.42507  -30.51224 13.76240  1.000 15.90110 ? 1154 SER A C     1 
ATOM   1136 O O     . SER A 1 146 ? 18.44843  -29.31796 14.06988  1.000 14.35589 ? 1154 SER A O     1 
ATOM   1137 C CB    . SER A 1 146 ? 16.91910  -32.27397 14.75159  1.000 21.48202 ? 1154 SER A CB    1 
ATOM   1138 O OG    . SER A 1 146 ? 15.90276  -31.32210 14.92473  1.000 20.74831 ? 1154 SER A OG    1 
ATOM   1139 N N     . GLY A 1 147 ? 18.53287  -30.95677 12.51734  1.000 16.18252 ? 1155 GLY A N     1 
ATOM   1140 C CA    . GLY A 1 147 ? 18.55362  -30.03348 11.40230  1.000 15.84540 ? 1155 GLY A CA    1 
ATOM   1141 C C     . GLY A 1 147 ? 19.94122  -29.86430 10.83043  1.000 15.58628 ? 1155 GLY A C     1 
ATOM   1142 O O     . GLY A 1 147 ? 20.92770  -29.73761 11.56708  1.000 15.48687 ? 1155 GLY A O     1 
ATOM   1143 N N     . LYS A 1 148 ? 20.02246  -29.87617 9.50164   1.000 14.31968 ? 1156 LYS A N     1 
ATOM   1144 C CA    . LYS A 1 148 ? 21.24248  -29.54534 8.79022   1.000 15.67117 ? 1156 LYS A CA    1 
ATOM   1145 C C     . LYS A 1 148 ? 21.06445  -28.45218 7.74895   1.000 13.51904 ? 1156 LYS A C     1 
ATOM   1146 O O     . LYS A 1 148 ? 22.07403  -27.96264 7.22673   1.000 15.78914 ? 1156 LYS A O     1 
ATOM   1147 C CB    . LYS A 1 148 ? 21.82652  -30.78436 8.09614   1.000 18.29097 ? 1156 LYS A CB    1 
ATOM   1148 C CG    . LYS A 1 148 ? 22.17206  -31.91310 9.04629   1.000 21.98449 ? 1156 LYS A CG    1 
ATOM   1149 C CD    . LYS A 1 148 ? 23.16702  -32.86316 8.40227   1.000 28.59033 ? 1156 LYS A CD    1 
ATOM   1150 C CE    . LYS A 1 148 ? 22.47394  -34.04426 7.76437   1.000 33.16606 ? 1156 LYS A CE    1 
ATOM   1151 N NZ    . LYS A 1 148 ? 23.46098  -35.09977 7.39321   1.000 40.67939 ? 1156 LYS A NZ    1 
ATOM   1152 N N     . ILE A 1 149 ? 19.82871  -28.04964 7.43370   1.000 13.43528 ? 1157 ILE A N     1 
ATOM   1153 C CA    . ILE A 1 149 ? 19.59674  -27.10707 6.34293   1.000 13.98307 ? 1157 ILE A CA    1 
ATOM   1154 C C     . ILE A 1 149 ? 20.29798  -25.78424 6.60469   1.000 14.06481 ? 1157 ILE A C     1 
ATOM   1155 O O     . ILE A 1 149 ? 20.77706  -25.12912 5.67019   1.000 13.93432 ? 1157 ILE A O     1 
ATOM   1156 C CB    . ILE A 1 149 ? 18.08294  -26.90839 6.10914   1.000 14.52689 ? 1157 ILE A CB    1 
ATOM   1157 C CG1   . ILE A 1 149 ? 17.46623  -28.17076 5.50851   1.000 21.17936 ? 1157 ILE A CG1   1 
ATOM   1158 C CG2   . ILE A 1 149 ? 17.80453  -25.69373 5.22520   1.000 15.35933 ? 1157 ILE A CG2   1 
ATOM   1159 C CD1   . ILE A 1 149 ? 15.94215  -28.12415 5.47679   1.000 24.20824 ? 1157 ILE A CD1   1 
ATOM   1160 N N     . MET A 1 150 ? 20.37313  -25.36650 7.86049   1.000 12.31029 ? 1158 MET A N     1 
ATOM   1161 C CA    . MET A 1 150 ? 20.77440  -24.01139 8.18285   1.000 10.90478 ? 1158 MET A CA    1 
ATOM   1162 C C     . MET A 1 150 ? 22.17266  -24.00057 8.82051   1.000 10.22994 ? 1158 MET A C     1 
ATOM   1163 O O     . MET A 1 150 ? 22.54936  -23.02912 9.48348   1.000 11.59334 ? 1158 MET A O     1 
ATOM   1164 C CB    . MET A 1 150 ? 19.75241  -23.41985 9.15356   1.000 11.46281 ? 1158 MET A CB    1 
ATOM   1165 C CG    . MET A 1 150 ? 18.38280  -23.09832 8.51013   1.000 10.53011 ? 1158 MET A CG    1 
ATOM   1166 S SD    . MET A 1 150 ? 18.30991  -22.07902 7.04141   1.000 13.54651 ? 1158 MET A SD    1 
ATOM   1167 C CE    . MET A 1 150 ? 18.04524  -20.46637 7.72582   1.000 18.62150 ? 1158 MET A CE    1 
ATOM   1168 N N     . LEU A 1 151 ? 22.93139  -25.07919 8.68389   1.000 10.51470 ? 1159 LEU A N     1 
ATOM   1169 C CA    . LEU A 1 151 ? 24.31617  -25.04088 9.14411   1.000 11.37252 ? 1159 LEU A CA    1 
ATOM   1170 C C     . LEU A 1 151 ? 25.07940  -23.97672 8.36493   1.000 13.18002 ? 1159 LEU A C     1 
ATOM   1171 O O     . LEU A 1 151 ? 24.83417  -23.76030 7.17448   1.000 14.06567 ? 1159 LEU A O     1 
ATOM   1172 C CB    . LEU A 1 151 ? 24.97787  -26.40164 8.95156   1.000 12.33820 ? 1159 LEU A CB    1 
ATOM   1173 C CG    . LEU A 1 151 ? 24.39545  -27.55739 9.77200   1.000 11.96571 ? 1159 LEU A CG    1 
ATOM   1174 C CD1   . LEU A 1 151 ? 25.10398  -28.85414 9.41649   1.000 18.60159 ? 1159 LEU A CD1   1 
ATOM   1175 C CD2   . LEU A 1 151 ? 24.50940  -27.29467 11.26935  1.000 14.30443 ? 1159 LEU A CD2   1 
ATOM   1176 N N     . LEU A 1 152 ? 26.00524  -23.29829 9.03924   1.000 11.23884 ? 1160 LEU A N     1 
ATOM   1177 C CA    . LEU A 1 152 ? 26.76122  -22.21732 8.40546   1.000 12.68443 ? 1160 LEU A CA    1 
ATOM   1178 C C     . LEU A 1 152 ? 27.90922  -22.78239 7.57233   1.000 11.86490 ? 1160 LEU A C     1 
ATOM   1179 O O     . LEU A 1 152 ? 28.76819  -23.49415 8.11316   1.000 13.22645 ? 1160 LEU A O     1 
ATOM   1180 C CB    . LEU A 1 152 ? 27.31773  -21.26228 9.45450   1.000 11.68697 ? 1160 LEU A CB    1 
ATOM   1181 C CG    . LEU A 1 152 ? 28.04361  -20.01722 8.92220   1.000 10.66627 ? 1160 LEU A CG    1 
ATOM   1182 C CD1   . LEU A 1 152 ? 27.08596  -19.08620 8.18305   1.000 15.13107 ? 1160 LEU A CD1   1 
ATOM   1183 C CD2   . LEU A 1 152 ? 28.75405  -19.26721 10.06960  1.000 12.66133 ? 1160 LEU A CD2   1 
ATOM   1184 N N     . PRO A 1 153 ? 27.96839  -22.49516 6.27201   1.000 11.38579 ? 1161 PRO A N     1 
ATOM   1185 C CA    . PRO A 1 153 ? 29.10695  -22.95548 5.46999   1.000 13.33243 ? 1161 PRO A CA    1 
ATOM   1186 C C     . PRO A 1 153 ? 30.34910  -22.15924 5.83347   1.000 12.81961 ? 1161 PRO A C     1 
ATOM   1187 O O     . PRO A 1 153 ? 30.40427  -20.94977 5.58245   1.000 14.21308 ? 1161 PRO A O     1 
ATOM   1188 C CB    . PRO A 1 153 ? 28.67150  -22.66219 4.02210   1.000 15.18424 ? 1161 PRO A CB    1 
ATOM   1189 C CG    . PRO A 1 153 ? 27.16190  -22.44148 4.08831   1.000 15.61815 ? 1161 PRO A CG    1 
ATOM   1190 C CD    . PRO A 1 153 ? 26.94081  -21.82775 5.45587   1.000 12.27733 ? 1161 PRO A CD    1 
ATOM   1191 N N     . GLU A 1 154 ? 31.33188  -22.81262 6.45716   1.000 12.77436 ? 1162 GLU A N     1 
ATOM   1192 C CA    . GLU A 1 154 ? 32.51929  -22.12687 6.95101   1.000 13.90395 ? 1162 GLU A CA    1 
ATOM   1193 C C     . GLU A 1 154 ? 33.76524  -22.38296 6.11247   1.000 15.87542 ? 1162 GLU A C     1 
ATOM   1194 O O     . GLU A 1 154 ? 34.82435  -21.82302 6.42361   1.000 16.95690 ? 1162 GLU A O     1 
ATOM   1195 C CB    . GLU A 1 154 ? 32.77428  -22.49527 8.42161   1.000 12.42132 ? 1162 GLU A CB    1 
ATOM   1196 C CG    . GLU A 1 154 ? 31.65142  -22.03499 9.32731   1.000 13.46030 ? 1162 GLU A CG    1 
ATOM   1197 C CD    . GLU A 1 154 ? 31.87958  -22.32341 10.79863  1.000 15.23400 ? 1162 GLU A CD    1 
ATOM   1198 O OE1   . GLU A 1 154 ? 32.97476  -22.78872 11.20622  1.000 16.60469 ? 1162 GLU A OE1   1 
ATOM   1199 O OE2   . GLU A 1 154 ? 30.92709  -22.05520 11.55551  1.000 16.89107 ? 1162 GLU A OE2   1 
ATOM   1200 N N     . GLU A 1 155 ? 33.66547  -23.18560 5.04891   1.000 15.89660 ? 1163 GLU A N     1 
ATOM   1201 C CA    . GLU A 1 155 ? 34.84677  -23.52307 4.25721   1.000 17.82912 ? 1163 GLU A CA    1 
ATOM   1202 C C     . GLU A 1 155 ? 35.53584  -22.27198 3.71255   1.000 18.00173 ? 1163 GLU A C     1 
ATOM   1203 O O     . GLU A 1 155 ? 36.77301  -22.20821 3.65186   1.000 18.20015 ? 1163 GLU A O     1 
ATOM   1204 C CB    . GLU A 1 155 ? 34.44961  -24.47947 3.12902   1.000 19.97591 ? 1163 GLU A CB    1 
ATOM   1205 C CG    . GLU A 1 155 ? 33.87385  -25.82177 3.62510   1.000 27.95384 ? 1163 GLU A CG    1 
ATOM   1206 C CD    . GLU A 1 155 ? 32.41121  -25.75856 4.12960   1.000 41.07114 ? 1163 GLU A CD    1 
ATOM   1207 O OE1   . GLU A 1 155 ? 31.67637  -24.78195 3.83831   1.000 25.59240 ? 1163 GLU A OE1   1 
ATOM   1208 O OE2   . GLU A 1 155 ? 32.00367  -26.69080 4.85848   1.000 40.28940 ? 1163 GLU A OE2   1 
ATOM   1209 N N     . ASP A 1 156 ? 34.75915  -21.25682 3.34054   1.000 14.30016 ? 1164 ASP A N     1 
ATOM   1210 C CA    . ASP A 1 156 ? 35.29214  -19.97976 2.88163   1.000 13.47692 ? 1164 ASP A CA    1 
ATOM   1211 C C     . ASP A 1 156 ? 35.03436  -18.94617 3.97280   1.000 16.31145 ? 1164 ASP A C     1 
ATOM   1212 O O     . ASP A 1 156 ? 33.90149  -18.45755 4.10943   1.000 13.95757 ? 1164 ASP A O     1 
ATOM   1213 C CB    . ASP A 1 156 ? 34.61023  -19.56359 1.57253   1.000 15.10520 ? 1164 ASP A CB    1 
ATOM   1214 C CG    . ASP A 1 156 ? 35.08844  -18.21248 1.06708   1.000 16.07325 ? 1164 ASP A CG    1 
ATOM   1215 O OD1   . ASP A 1 156 ? 36.03668  -17.63403 1.64858   1.000 15.91763 ? 1164 ASP A OD1   1 
ATOM   1216 O OD2   . ASP A 1 156 ? 34.50702  -17.71881 0.08069   1.000 19.94055 ? 1164 ASP A OD2   1 
ATOM   1217 N N     . PRO A 1 157 ? 36.03765  -18.56994 4.77450   1.000 15.24268 ? 1165 PRO A N     1 
ATOM   1218 C CA    . PRO A 1 157 ? 35.80438  -17.57105 5.82449   1.000 13.34017 ? 1165 PRO A CA    1 
ATOM   1219 C C     . PRO A 1 157 ? 35.56927  -16.17036 5.28820   1.000 14.01708 ? 1165 PRO A C     1 
ATOM   1220 O O     . PRO A 1 157 ? 35.28090  -15.26982 6.08307   1.000 16.17970 ? 1165 PRO A O     1 
ATOM   1221 C CB    . PRO A 1 157 ? 37.08368  -17.65777 6.68099   1.000 16.94652 ? 1165 PRO A CB    1 
ATOM   1222 C CG    . PRO A 1 157 ? 38.12798  -18.10468 5.72077   1.000 19.46343 ? 1165 PRO A CG    1 
ATOM   1223 C CD    . PRO A 1 157 ? 37.43088  -19.04744 4.76321   1.000 19.42096 ? 1165 PRO A CD    1 
ATOM   1224 N N     . ASN A 1 158 ? 35.68393  -15.95935 3.96979   1.000 14.96160 ? 1166 ASN A N     1 
ATOM   1225 C CA    . ASN A 1 158 ? 35.38344  -14.67823 3.34906   1.000 15.17901 ? 1166 ASN A CA    1 
ATOM   1226 C C     . ASN A 1 158 ? 34.14830  -14.74922 2.45729   1.000 15.16748 ? 1166 ASN A C     1 
ATOM   1227 O O     . ASN A 1 158 ? 33.95899  -13.88917 1.59187   1.000 16.14902 ? 1166 ASN A O     1 
ATOM   1228 C CB    . ASN A 1 158 ? 36.60065  -14.16960 2.57758   1.000 18.72297 ? 1166 ASN A CB    1 
ATOM   1229 C CG    . ASN A 1 158 ? 37.80496  -14.02804 3.46844   1.000 20.34315 ? 1166 ASN A CG    1 
ATOM   1230 O OD1   . ASN A 1 158 ? 37.69848  -13.53616 4.59078   1.000 20.89035 ? 1166 ASN A OD1   1 
ATOM   1231 N ND2   . ASN A 1 158 ? 38.94655  -14.52063 3.00181   1.000 24.27675 ? 1166 ASN A ND2   1 
ATOM   1232 N N     . ALA A 1 159 ? 33.29417  -15.74650 2.68295   1.000 13.68998 ? 1167 ALA A N     1 
ATOM   1233 C CA    . ALA A 1 159 ? 32.04054  -15.87782 1.95641   1.000 13.93858 ? 1167 ALA A CA    1 
ATOM   1234 C C     . ALA A 1 159 ? 31.09781  -14.72411 2.28800   1.000 12.63154 ? 1167 ALA A C     1 
ATOM   1235 O O     . ALA A 1 159 ? 31.27646  -13.99086 3.26851   1.000 14.23848 ? 1167 ALA A O     1 
ATOM   1236 C CB    . ALA A 1 159 ? 31.37731  -17.20394 2.33950   1.000 15.27256 ? 1167 ALA A CB    1 
ATOM   1237 N N     . THR A 1 160 ? 30.07474  -14.56609 1.44618   1.000 12.42837 ? 1168 THR A N     1 
ATOM   1238 C CA    . THR A 1 160 ? 29.00456  -13.61072 1.68246   1.000 11.82729 ? 1168 THR A CA    1 
ATOM   1239 C C     . THR A 1 160 ? 27.75657  -14.37293 2.10884   1.000 11.75942 ? 1168 THR A C     1 
ATOM   1240 O O     . THR A 1 160 ? 27.42445  -15.40857 1.52146   1.000 12.84550 ? 1168 THR A O     1 
ATOM   1241 C CB    . THR A 1 160 ? 28.71996  -12.79456 0.41563   1.000 12.25966 ? 1168 THR A CB    1 
ATOM   1242 O OG1   . THR A 1 160 ? 29.89120  -12.01540 0.10998   1.000 17.85075 ? 1168 THR A OG1   1 
ATOM   1243 C CG2   . THR A 1 160 ? 27.56905  -11.84658 0.64348   1.000 14.77486 ? 1168 THR A CG2   1 
ATOM   1244 N N     . HIS A 1 161 ? 27.08512  -13.86498 3.14041   1.000 11.39861 ? 1169 HIS A N     1 
ATOM   1245 C CA    . HIS A 1 161 ? 25.91341  -14.50539 3.73345   1.000 10.91043 ? 1169 HIS A CA    1 
ATOM   1246 C C     . HIS A 1 161 ? 24.80180  -13.46758 3.82858   1.000 10.72099 ? 1169 HIS A C     1 
ATOM   1247 O O     . HIS A 1 161 ? 24.88757  -12.53193 4.63279   1.000 11.59667 ? 1169 HIS A O     1 
ATOM   1248 C CB    . HIS A 1 161 ? 26.23691  -15.08795 5.12015   1.000 10.36778 ? 1169 HIS A CB    1 
ATOM   1249 C CG    . HIS A 1 161 ? 27.35261  -16.08670 5.13051   1.000 11.39113 ? 1169 HIS A CG    1 
ATOM   1250 N ND1   . HIS A 1 161 ? 27.19180  -17.39918 4.72781   1.000 11.31712 ? 1169 HIS A ND1   1 
ATOM   1251 C CD2   . HIS A 1 161 ? 28.64809  -15.96222 5.51058   1.000 12.71592 ? 1169 HIS A CD2   1 
ATOM   1252 C CE1   . HIS A 1 161 ? 28.34665  -18.03442 4.84752   1.000 11.67290 ? 1169 HIS A CE1   1 
ATOM   1253 N NE2   . HIS A 1 161 ? 29.24413  -17.18576 5.32917   1.000 11.85168 ? 1169 HIS A NE2   1 
ATOM   1254 N N     . ILE A 1 162 ? 23.75127  -13.64043 3.02506   1.000 11.31320 ? 1170 ILE A N     1 
ATOM   1255 C CA    . ILE A 1 162 ? 22.58972  -12.75534 3.01180   1.000 10.67575 ? 1170 ILE A CA    1 
ATOM   1256 C C     . ILE A 1 162 ? 21.46439  -13.44807 3.77702   1.000 11.42893 ? 1170 ILE A C     1 
ATOM   1257 O O     . ILE A 1 162 ? 20.99230  -14.51360 3.37042   1.000 11.81310 ? 1170 ILE A O     1 
ATOM   1258 C CB    . ILE A 1 162 ? 22.14753  -12.42890 1.57220   1.000 13.08534 ? 1170 ILE A CB    1 
ATOM   1259 C CG1   . ILE A 1 162 ? 23.28351  -11.75590 0.76965   1.000 11.09741 ? 1170 ILE A CG1   1 
ATOM   1260 C CG2   . ILE A 1 162 ? 20.89684  -11.53908 1.58659   1.000 12.94076 ? 1170 ILE A CG2   1 
ATOM   1261 C CD1   . ILE A 1 162 ? 23.01641  -11.72186 -0.75883  1.000 13.63811 ? 1170 ILE A CD1   1 
ATOM   1262 N N     . MET A 1 163 ? 21.00824  -12.84258 4.87144   1.000 11.77666 ? 1171 MET A N     1 
ATOM   1263 C CA    . MET A 1 163 ? 20.15928  -13.50647 5.85674   1.000 9.82925  ? 1171 MET A CA    1 
ATOM   1264 C C     . MET A 1 163 ? 18.82367  -12.78526 5.86940   1.000 10.27823 ? 1171 MET A C     1 
ATOM   1265 O O     . MET A 1 163 ? 18.76866  -11.59547 6.19814   1.000 12.17342 ? 1171 MET A O     1 
ATOM   1266 C CB    . MET A 1 163 ? 20.84657  -13.30914 7.20314   1.000 10.93613 ? 1171 MET A CB    1 
ATOM   1267 C CG    . MET A 1 163 ? 22.21717  -13.99039 7.28448   1.000 11.02234 ? 1171 MET A CG    1 
ATOM   1268 S SD    . MET A 1 163 ? 23.05409  -13.65411 8.85538   1.000 11.84051 ? 1171 MET A SD    1 
ATOM   1269 C CE    . MET A 1 163 ? 24.75766  -13.92182 8.38424   1.000 15.72715 ? 1171 MET A CE    1 
ATOM   1270 N N     . ILE A 1 164 ? 17.75634  -13.48736 5.46933   1.000 10.39208 ? 1172 ILE A N     1 
ATOM   1271 C CA    . ILE A 1 164 ? 16.41931  -12.90424 5.33435   1.000 11.16232 ? 1172 ILE A CA    1 
ATOM   1272 C C     . ILE A 1 164 ? 15.51570  -13.50606 6.40592   1.000 10.32120 ? 1172 ILE A C     1 
ATOM   1273 O O     . ILE A 1 164 ? 15.21419  -14.70930 6.36990   1.000 11.46141 ? 1172 ILE A O     1 
ATOM   1274 C CB    . ILE A 1 164 ? 15.81631  -13.17528 3.94454   1.000 12.06244 ? 1172 ILE A CB    1 
ATOM   1275 C CG1   . ILE A 1 164 ? 16.80731  -12.84721 2.81689   1.000 14.23293 ? 1172 ILE A CG1   1 
ATOM   1276 C CG2   . ILE A 1 164 ? 14.50056  -12.40964 3.81720   1.000 13.03425 ? 1172 ILE A CG2   1 
ATOM   1277 C CD1   . ILE A 1 164 ? 17.27432  -11.42879 2.82548   1.000 12.92382 ? 1172 ILE A CD1   1 
ATOM   1278 N N     . ALA A 1 165 ? 15.05258  -12.66815 7.33215   1.000 10.94596 ? 1173 ALA A N     1 
ATOM   1279 C CA    . ALA A 1 165 ? 14.27386  -13.11470 8.47609   1.000 10.53668 ? 1173 ALA A CA    1 
ATOM   1280 C C     . ALA A 1 165 ? 12.96738  -12.34126 8.57146   1.000 11.76362 ? 1173 ALA A C     1 
ATOM   1281 O O     . ALA A 1 165 ? 12.90872  -11.14070 8.28705   1.000 12.33990 ? 1173 ALA A O     1 
ATOM   1282 C CB    . ALA A 1 165 ? 15.04335  -12.83885 9.78695   1.000 11.24900 ? 1173 ALA A CB    1 
ATOM   1283 N N     . THR A 1 166 ? 11.92948  -13.03803 9.04334   1.000 11.83614 ? 1174 THR A N     1 
ATOM   1284 C CA    . THR A 1 166 ? 10.75753  -12.38336 9.60401   1.000 12.02594 ? 1174 THR A CA    1 
ATOM   1285 C C     . THR A 1 166 ? 10.52421  -12.92196 11.00726  1.000 12.90770 ? 1174 THR A C     1 
ATOM   1286 O O     . THR A 1 166 ? 10.68315  -14.11757 11.25572  1.000 11.84596 ? 1174 THR A O     1 
ATOM   1287 C CB    . THR A 1 166 ? 9.48258   -12.55983 8.73959   1.000 14.31668 ? 1174 THR A CB    1 
ATOM   1288 O OG1   . THR A 1 166 ? 9.16404   -13.94657 8.59815   1.000 15.45053 ? 1174 THR A OG1   1 
ATOM   1289 C CG2   . THR A 1 166 ? 9.67007   -11.90589 7.36389   1.000 16.19290 ? 1174 THR A CG2   1 
ATOM   1290 N N     . GLY A 1 167 ? 10.15986  -12.02988 11.91553  1.000 13.56287 ? 1175 GLY A N     1 
ATOM   1291 C CA    . GLY A 1 167 ? 9.85588   -12.45156 13.28116  1.000 12.64490 ? 1175 GLY A CA    1 
ATOM   1292 C C     . GLY A 1 167 ? 10.94240  -13.31078 13.91219  1.000 12.00527 ? 1175 GLY A C     1 
ATOM   1293 O O     . GLY A 1 167 ? 12.14647  -13.00062 13.84214  1.000 11.94361 ? 1175 GLY A O     1 
ATOM   1294 N N     . THR A 1 168 ? 10.50891  -14.42980 14.50878  1.000 12.65250 ? 1176 THR A N     1 
ATOM   1295 C CA    . THR A 1 168 ? 11.41540  -15.34858 15.19518  1.000 10.99564 ? 1176 THR A CA    1 
ATOM   1296 C C     . THR A 1 168 ? 12.43114  -15.99008 14.25802  1.000 11.84442 ? 1176 THR A C     1 
ATOM   1297 O O     . THR A 1 168 ? 13.38472  -16.61746 14.74205  1.000 12.97218 ? 1176 THR A O     1 
ATOM   1298 C CB    . THR A 1 168 ? 10.61180  -16.43829 15.93224  1.000 11.65199 ? 1176 THR A CB    1 
ATOM   1299 O OG1   . THR A 1 168 ? 9.75220   -17.12955 15.01558  1.000 13.35568 ? 1176 THR A OG1   1 
ATOM   1300 C CG2   . THR A 1 168 ? 9.75291   -15.84447 17.05419  1.000 13.09050 ? 1176 THR A CG2   1 
ATOM   1301 N N     . GLY A 1 169 ? 12.23723  -15.88083 12.93869  1.000 12.08992 ? 1177 GLY A N     1 
ATOM   1302 C CA    . GLY A 1 169 ? 13.25008  -16.35671 11.99912  1.000 13.01937 ? 1177 GLY A CA    1 
ATOM   1303 C C     . GLY A 1 169 ? 14.60651  -15.68861 12.14741  1.000 10.06963 ? 1177 GLY A C     1 
ATOM   1304 O O     . GLY A 1 169 ? 15.57818  -16.16617 11.55175  1.000 11.57474 ? 1177 GLY A O     1 
ATOM   1305 N N     . VAL A 1 170 ? 14.68542  -14.60261 12.91885  1.000 10.95107 ? 1178 VAL A N     1 
ATOM   1306 C CA    . VAL A 1 170 ? 15.96980  -14.00362 13.26056  1.000 11.24226 ? 1178 VAL A CA    1 
ATOM   1307 C C     . VAL A 1 170 ? 16.87228  -14.95840 14.03899  1.000 10.99768 ? 1178 VAL A C     1 
ATOM   1308 O O     . VAL A 1 170 ? 18.09556  -14.76652 14.06292  1.000 11.24247 ? 1178 VAL A O     1 
ATOM   1309 C CB    . VAL A 1 170 ? 15.75857  -12.66808 13.99402  1.000 14.88169 ? 1178 VAL A CB    1 
ATOM   1310 C CG1   . VAL A 1 170 ? 15.38367  -12.90466 15.44975  1.000 12.33805 ? 1178 VAL A CG1   1 
ATOM   1311 C CG2   . VAL A 1 170 ? 16.98831  -11.77702 13.84787  1.000 17.16458 ? 1178 VAL A CG2   1 
ATOM   1312 N N     . ALA A 1 171 ? 16.30331  -15.98917 14.68591  1.000 11.06000 ? 1179 ALA A N     1 
ATOM   1313 C CA    . ALA A 1 171 ? 17.03583  -16.84259 15.62800  1.000 9.84629  ? 1179 ALA A CA    1 
ATOM   1314 C C     . ALA A 1 171 ? 18.36393  -17.40717 15.10438  1.000 10.15503 ? 1179 ALA A C     1 
ATOM   1315 O O     . ALA A 1 171 ? 19.41241  -17.15151 15.72731  1.000 10.02085 ? 1179 ALA A O     1 
ATOM   1316 C CB    . ALA A 1 171 ? 16.12566  -17.93885 16.18759  1.000 10.66926 ? 1179 ALA A CB    1 
ATOM   1317 N N     . PRO A 1 172 ? 18.40460  -18.16813 14.00829  1.000 10.27091 ? 1180 PRO A N     1 
ATOM   1318 C CA    . PRO A 1 172 ? 19.70908  -18.70726 13.58424  1.000 10.04192 ? 1180 PRO A CA    1 
ATOM   1319 C C     . PRO A 1 172 ? 20.70669  -17.61504 13.27751  1.000 10.11960 ? 1180 PRO A C     1 
ATOM   1320 O O     . PRO A 1 172 ? 21.91366  -17.81868 13.45944  1.000 10.37051 ? 1180 PRO A O     1 
ATOM   1321 C CB    . PRO A 1 172 ? 19.37448  -19.52916 12.33217  1.000 10.17653 ? 1180 PRO A CB    1 
ATOM   1322 C CG    . PRO A 1 172 ? 18.09389  -18.89471 11.79294  1.000 10.56492 ? 1180 PRO A CG    1 
ATOM   1323 C CD    . PRO A 1 172 ? 17.33278  -18.53838 13.04461  1.000 10.44665 ? 1180 PRO A CD    1 
ATOM   1324 N N     . PHE A 1 173 ? 20.22956  -16.46486 12.79131  1.000 10.16902 ? 1181 PHE A N     1 
ATOM   1325 C CA    . PHE A 1 173 ? 21.12125  -15.37463 12.40247  1.000 10.02998 ? 1181 PHE A CA    1 
ATOM   1326 C C     . PHE A 1 173 ? 21.75033  -14.70193 13.61245  1.000 10.21954 ? 1181 PHE A C     1 
ATOM   1327 O O     . PHE A 1 173 ? 22.89619  -14.24646 13.54006  1.000 9.98717  ? 1181 PHE A O     1 
ATOM   1328 C CB    . PHE A 1 173 ? 20.36751  -14.38887 11.51153  1.000 10.56294 ? 1181 PHE A CB    1 
ATOM   1329 C CG    . PHE A 1 173 ? 19.66767  -15.05227 10.35062  1.000 10.79550 ? 1181 PHE A CG    1 
ATOM   1330 C CD1   . PHE A 1 173 ? 20.27095  -16.11042 9.68067   1.000 9.71454  ? 1181 PHE A CD1   1 
ATOM   1331 C CD2   . PHE A 1 173 ? 18.39030  -14.64487 9.95597   1.000 10.85267 ? 1181 PHE A CD2   1 
ATOM   1332 C CE1   . PHE A 1 173 ? 19.62815  -16.73967 8.60003   1.000 12.05263 ? 1181 PHE A CE1   1 
ATOM   1333 C CE2   . PHE A 1 173 ? 17.73806  -15.26201 8.88386   1.000 10.76472 ? 1181 PHE A CE2   1 
ATOM   1334 C CZ    . PHE A 1 173 ? 18.34931  -16.31348 8.21063   1.000 11.19267 ? 1181 PHE A CZ    1 
ATOM   1335 N N     . ARG A 1 174 ? 21.03488  -14.63461 14.73427  1.000 9.87700  ? 1182 ARG A N     1 
ATOM   1336 C CA    . ARG A 1 174 ? 21.69173  -14.19018 15.95772  1.000 9.18608  ? 1182 ARG A CA    1 
ATOM   1337 C C     . ARG A 1 174 ? 22.89386  -15.07716 16.26635  1.000 10.47382 ? 1182 ARG A C     1 
ATOM   1338 O O     . ARG A 1 174 ? 23.95736  -14.58063 16.66150  1.000 10.21278 ? 1182 ARG A O     1 
ATOM   1339 C CB    . ARG A 1 174 ? 20.69580  -14.16669 17.12416  1.000 9.91434  ? 1182 ARG A CB    1 
ATOM   1340 C CG    . ARG A 1 174 ? 21.30930  -13.64991 18.43393  1.000 8.63386  ? 1182 ARG A CG    1 
ATOM   1341 C CD    . ARG A 1 174 ? 20.25044  -13.62318 19.55163  1.000 10.17167 ? 1182 ARG A CD    1 
ATOM   1342 N NE    . ARG A 1 174 ? 20.78551  -13.11921 20.81855  1.000 9.97149  ? 1182 ARG A NE    1 
ATOM   1343 C CZ    . ARG A 1 174 ? 21.31169  -13.89132 21.76719  1.000 10.86775 ? 1182 ARG A CZ    1 
ATOM   1344 N NH1   . ARG A 1 174 ? 21.45238  -15.19946 21.60000  1.000 10.95200 ? 1182 ARG A NH1   1 
ATOM   1345 N NH2   . ARG A 1 174 ? 21.70573  -13.33224 22.90959  1.000 12.01254 ? 1182 ARG A NH2   1 
ATOM   1346 N N     . GLY A 1 175 ? 22.74464  -16.38957 16.08445  1.000 9.61357  ? 1183 GLY A N     1 
ATOM   1347 C CA    . GLY A 1 175 ? 23.86241  -17.29979 16.30498  1.000 9.82764  ? 1183 GLY A CA    1 
ATOM   1348 C C     . GLY A 1 175 ? 24.98979  -17.12010 15.30203  1.000 10.26987 ? 1183 GLY A C     1 
ATOM   1349 O O     . GLY A 1 175 ? 26.16417  -17.05956 15.68939  1.000 10.67635 ? 1183 GLY A O     1 
ATOM   1350 N N     . TYR A 1 176 ? 24.65677  -17.06159 14.00371  1.000 9.79931  ? 1184 TYR A N     1 
ATOM   1351 C CA    . TYR A 1 176 ? 25.67959  -16.83429 12.98279  1.000 8.95176  ? 1184 TYR A CA    1 
ATOM   1352 C C     . TYR A 1 176 ? 26.47866  -15.58196 13.30891  1.000 10.31342 ? 1184 TYR A C     1 
ATOM   1353 O O     . TYR A 1 176 ? 27.71368  -15.58022 13.25154  1.000 10.54850 ? 1184 TYR A O     1 
ATOM   1354 C CB    . TYR A 1 176 ? 25.03948  -16.58199 11.61613  1.000 10.82992 ? 1184 TYR A CB    1 
ATOM   1355 C CG    . TYR A 1 176 ? 24.33430  -17.70161 10.88365  1.000 10.26701 ? 1184 TYR A CG    1 
ATOM   1356 C CD1   . TYR A 1 176 ? 24.22445  -18.98943 11.38502  1.000 11.23023 ? 1184 TYR A CD1   1 
ATOM   1357 C CD2   . TYR A 1 176 ? 23.71860  -17.41746 9.67244   1.000 11.69674 ? 1184 TYR A CD2   1 
ATOM   1358 C CE1   . TYR A 1 176 ? 23.51258  -19.98834 10.66968  1.000 11.84162 ? 1184 TYR A CE1   1 
ATOM   1359 C CE2   . TYR A 1 176 ? 23.01501  -18.37107 8.96979   1.000 12.51756 ? 1184 TYR A CE2   1 
ATOM   1360 C CZ    . TYR A 1 176 ? 22.91763  -19.64913 9.46267   1.000 11.65153 ? 1184 TYR A CZ    1 
ATOM   1361 O OH    . TYR A 1 176 ? 22.19675  -20.56469 8.72271   1.000 12.36210 ? 1184 TYR A OH    1 
ATOM   1362 N N     . LEU A 1 177 ? 25.77502  -14.49345 13.62520  1.000 10.42904 ? 1185 LEU A N     1 
ATOM   1363 C CA    . LEU A 1 177 ? 26.42812  -13.18988 13.73558  1.000 10.29931 ? 1185 LEU A CA    1 
ATOM   1364 C C     . LEU A 1 177 ? 27.28894  -13.09691 14.99301  1.000 10.43770 ? 1185 LEU A C     1 
ATOM   1365 O O     . LEU A 1 177 ? 28.35410  -12.46330 14.97344  1.000 10.31183 ? 1185 LEU A O     1 
ATOM   1366 C CB    . LEU A 1 177 ? 25.39224  -12.06775 13.66413  1.000 11.51223 ? 1185 LEU A CB    1 
ATOM   1367 C CG    . LEU A 1 177 ? 24.70466  -11.92800 12.29958  1.000 10.82665 ? 1185 LEU A CG    1 
ATOM   1368 C CD1   . LEU A 1 177 ? 23.46347  -11.07526 12.43300  1.000 13.24170 ? 1185 LEU A CD1   1 
ATOM   1369 C CD2   . LEU A 1 177 ? 25.66680  -11.33045 11.26407  1.000 13.20732 ? 1185 LEU A CD2   1 
ATOM   1370 N N     . ARG A 1 178 ? 26.85991  -13.72276 16.09481  1.000 9.74954  ? 1186 ARG A N     1 
ATOM   1371 C CA    . ARG A 1 178 ? 27.73216  -13.76585 17.26255  1.000 10.80252 ? 1186 ARG A CA    1 
ATOM   1372 C C     . ARG A 1 178 ? 29.01259  -14.53534 16.95243  1.000 9.62964  ? 1186 ARG A C     1 
ATOM   1373 O O     . ARG A 1 178 ? 30.10330  -14.13428 17.38944  1.000 10.95089 ? 1186 ARG A O     1 
ATOM   1374 C CB    . ARG A 1 178 ? 26.97559  -14.37035 18.43543  1.000 10.24611 ? 1186 ARG A CB    1 
ATOM   1375 C CG    . ARG A 1 178 ? 26.18640  -13.37670 19.21896  1.000 10.24819 ? 1186 ARG A CG    1 
ATOM   1376 C CD    . ARG A 1 178 ? 25.74694  -13.94737 20.55735  1.000 11.60602 ? 1186 ARG A CD    1 
ATOM   1377 N NE    . ARG A 1 178 ? 25.03941  -12.92191 21.31258  1.000 12.51065 ? 1186 ARG A NE    1 
ATOM   1378 C CZ    . ARG A 1 178 ? 25.14931  -12.74608 22.62294  1.000 11.66529 ? 1186 ARG A CZ    1 
ATOM   1379 N NH1   . ARG A 1 178 ? 25.82770  -13.59997 23.38314  1.000 12.19580 ? 1186 ARG A NH1   1 
ATOM   1380 N NH2   . ARG A 1 178 ? 24.56539  -11.69036 23.18851  1.000 11.64463 ? 1186 ARG A NH2   1 
ATOM   1381 N N     . ARG A 1 179 ? 28.91993  -15.63549 16.20310  1.000 10.23250 ? 1187 ARG A N     1 
ATOM   1382 C CA    . ARG A 1 179 ? 30.12012  -16.39865 15.85597  1.000 10.57462 ? 1187 ARG A CA    1 
ATOM   1383 C C     . ARG A 1 179 ? 31.01156  -15.60930 14.90097  1.000 12.53109 ? 1187 ARG A C     1 
ATOM   1384 O O     . ARG A 1 179 ? 32.24798  -15.63921 15.00132  1.000 11.52802 ? 1187 ARG A O     1 
ATOM   1385 C CB    . ARG A 1 179 ? 29.72031  -17.74281 15.23658  1.000 9.05462  ? 1187 ARG A CB    1 
ATOM   1386 C CG    . ARG A 1 179 ? 30.88171  -18.64142 14.81125  1.000 11.22790 ? 1187 ARG A CG    1 
ATOM   1387 C CD    . ARG A 1 179 ? 30.39477  -20.07665 14.52746  1.000 11.07874 ? 1187 ARG A CD    1 
ATOM   1388 N NE    . ARG A 1 179 ? 31.44625  -20.96233 14.03175  1.000 10.90233 ? 1187 ARG A NE    1 
ATOM   1389 C CZ    . ARG A 1 179 ? 32.26509  -21.65119 14.81622  1.000 11.78452 ? 1187 ARG A CZ    1 
ATOM   1390 N NH1   . ARG A 1 179 ? 32.25197  -21.50820 16.13893  1.000 11.57569 ? 1187 ARG A NH1   1 
ATOM   1391 N NH2   . ARG A 1 179 ? 33.12693  -22.49643 14.26802  1.000 11.69659 ? 1187 ARG A NH2   1 
ATOM   1392 N N     . MET A 1 180 ? 30.40151  -14.87932 13.97805  1.000 11.07335 ? 1188 MET A N     1 
ATOM   1393 C CA    . MET A 1 180 ? 31.14913  -14.12657 12.98354  1.000 10.53916 ? 1188 MET A CA    1 
ATOM   1394 C C     . MET A 1 180 ? 31.85177  -12.93256 13.62273  1.000 10.99637 ? 1188 MET A C     1 
ATOM   1395 O O     . MET A 1 180 ? 32.98493  -12.60467 13.24743  1.000 12.14190 ? 1188 MET A O     1 
ATOM   1396 C CB    . MET A 1 180 ? 30.07031  -13.65400 12.02078  1.000 12.32347 ? 1188 MET A CB    1 
ATOM   1397 C CG    . MET A 1 180 ? 29.78802  -14.63238 10.93269  1.000 10.69293 ? 1188 MET A CG    1 
ATOM   1398 S SD    . MET A 1 180 ? 28.43920  -14.04925 9.90261   1.000 12.93460 ? 1188 MET A SD    1 
ATOM   1399 C CE    . MET A 1 180 ? 27.98594  -15.57164 9.07975   1.000 16.32554 ? 1188 MET A CE    1 
ATOM   1400 N N     . PHE A 1 181 ? 31.20690  -12.27685 14.58181  1.000 10.88960 ? 1189 PHE A N     1 
ATOM   1401 C CA    . PHE A 1 181 ? 31.64997  -10.95962 15.05635  1.000 11.52003 ? 1189 PHE A CA    1 
ATOM   1402 C C     . PHE A 1 181 ? 31.93952  -10.86340 16.54326  1.000 13.21344 ? 1189 PHE A C     1 
ATOM   1403 O O     . PHE A 1 181 ? 32.85645  -10.11563 16.92492  1.000 14.37048 ? 1189 PHE A O     1 
ATOM   1404 C CB    . PHE A 1 181 ? 30.63727  -9.86842  14.67877  1.000 12.65273 ? 1189 PHE A CB    1 
ATOM   1405 C CG    . PHE A 1 181 ? 30.47358  -9.71083  13.19938  1.000 12.51015 ? 1189 PHE A CG    1 
ATOM   1406 C CD1   . PHE A 1 181 ? 31.57709  -9.50235  12.38529  1.000 12.14557 ? 1189 PHE A CD1   1 
ATOM   1407 C CD2   . PHE A 1 181 ? 29.22937  -9.85250  12.60956  1.000 12.11539 ? 1189 PHE A CD2   1 
ATOM   1408 C CE1   . PHE A 1 181 ? 31.42675  -9.38672  10.99318  1.000 11.84675 ? 1189 PHE A CE1   1 
ATOM   1409 C CE2   . PHE A 1 181 ? 29.07205  -9.74250  11.22296  1.000 12.30024 ? 1189 PHE A CE2   1 
ATOM   1410 C CZ    . PHE A 1 181 ? 30.16607  -9.52940  10.41327  1.000 12.60325 ? 1189 PHE A CZ    1 
ATOM   1411 N N     . MET A 1 182 ? 31.17270  -11.53205 17.40825  1.000 11.05950 ? 1190 MET A N     1 
ATOM   1412 C CA    . MET A 1 182 ? 31.33251  -11.17782 18.81416  1.000 11.75063 ? 1190 MET A CA    1 
ATOM   1413 C C     . MET A 1 182 ? 32.29687  -12.09066 19.56500  1.000 10.96059 ? 1190 MET A C     1 
ATOM   1414 O O     . MET A 1 182 ? 33.02771  -11.59323 20.42840  1.000 14.43398 ? 1190 MET A O     1 
ATOM   1415 C CB    . MET A 1 182 ? 29.97764  -10.96996 19.51665  1.000 18.98216 ? 1190 MET A CB    1 
ATOM   1416 C CG    . MET A 1 182 ? 29.92685  -11.07615 21.03813  1.000 12.24593 ? 1190 MET A CG    1 
ATOM   1417 S SD    . MET A 1 182 ? 28.29242  -11.32279 21.77066  1.000 13.43168 ? 1190 MET A SD    1 
ATOM   1418 C CE    . MET A 1 182 ? 27.37810  -9.94672  21.06305  1.000 14.73340 ? 1190 MET A CE    1 
ATOM   1419 N N     . GLU A 1 183 ? 32.38105  -13.37654 19.22439  1.000 9.82139  ? 1191 GLU A N     1 
ATOM   1420 C CA    . GLU A 1 183 ? 33.12386  -14.37250 19.99536  1.000 9.73922  ? 1191 GLU A CA    1 
ATOM   1421 C C     . GLU A 1 183 ? 34.53762  -14.56318 19.45696  1.000 11.79951 ? 1191 GLU A C     1 
ATOM   1422 O O     . GLU A 1 183 ? 34.78710  -14.48683 18.25600  1.000 12.93929 ? 1191 GLU A O     1 
ATOM   1423 C CB    . GLU A 1 183 ? 32.40225  -15.71981 19.95269  1.000 12.45784 ? 1191 GLU A CB    1 
ATOM   1424 C CG    . GLU A 1 183 ? 31.04852  -15.70246 20.65661  1.000 10.85249 ? 1191 GLU A CG    1 
ATOM   1425 C CD    . GLU A 1 183 ? 30.30213  -17.02154 20.52788  1.000 10.69723 ? 1191 GLU A CD    1 
ATOM   1426 O OE1   . GLU A 1 183 ? 30.57162  -17.78601 19.57340  1.000 11.11662 ? 1191 GLU A OE1   1 
ATOM   1427 O OE2   . GLU A 1 183 ? 29.40979  -17.23535 21.37994  1.000 10.70587 ? 1191 GLU A OE2   1 
ATOM   1428 N N     . ASP A 1 184 ? 35.47137  -14.87251 20.36111  1.000 13.25573 ? 1192 ASP A N     1 
ATOM   1429 C CA    . ASP A 1 184 ? 36.86084  -15.10793 19.95019  1.000 11.79455 ? 1192 ASP A CA    1 
ATOM   1430 C C     . ASP A 1 184 ? 37.02047  -16.57240 19.55432  1.000 13.79429 ? 1192 ASP A C     1 
ATOM   1431 O O     . ASP A 1 184 ? 37.37062  -17.43009 20.37127  1.000 13.62104 ? 1192 ASP A O     1 
ATOM   1432 C CB    . ASP A 1 184 ? 37.82289  -14.70875 21.06561  1.000 13.65236 ? 1192 ASP A CB    1 
ATOM   1433 C CG    . ASP A 1 184 ? 39.28893  -14.78453 20.63342  1.000 17.16163 ? 1192 ASP A CG    1 
ATOM   1434 O OD1   . ASP A 1 184 ? 39.57399  -14.92828 19.42936  1.000 17.07346 ? 1192 ASP A OD1   1 
ATOM   1435 O OD2   . ASP A 1 184 ? 40.17159  -14.71158 21.51293  1.000 16.90797 ? 1192 ASP A OD2   1 
ATOM   1436 N N     . VAL A 1 185 ? 36.76847  -16.87108 18.28060  1.000 12.69964 ? 1193 VAL A N     1 
ATOM   1437 C CA    . VAL A 1 185 ? 36.87139  -18.23291 17.75594  1.000 13.36215 ? 1193 VAL A CA    1 
ATOM   1438 C C     . VAL A 1 185 ? 38.08031  -18.30341 16.82851  1.000 15.10124 ? 1193 VAL A C     1 
ATOM   1439 O O     . VAL A 1 185 ? 37.97781  -17.93289 15.65095  1.000 14.89147 ? 1193 VAL A O     1 
ATOM   1440 C CB    . VAL A 1 185 ? 35.57917  -18.65884 17.03048  1.000 12.45082 ? 1193 VAL A CB    1 
ATOM   1441 C CG1   . VAL A 1 185 ? 35.64836  -20.11864 16.59855  1.000 13.47116 ? 1193 VAL A CG1   1 
ATOM   1442 C CG2   . VAL A 1 185 ? 34.36683  -18.41327 17.94138  1.000 14.10868 ? 1193 VAL A CG2   1 
ATOM   1443 N N     . PRO A 1 186 ? 39.23798  -18.76279 17.31296  1.000 17.03443 ? 1194 PRO A N     1 
ATOM   1444 C CA    . PRO A 1 186 ? 40.45372  -18.68494 16.48504  1.000 19.70937 ? 1194 PRO A CA    1 
ATOM   1445 C C     . PRO A 1 186 ? 40.38501  -19.47386 15.19733  1.000 20.21153 ? 1194 PRO A C     1 
ATOM   1446 O O     . PRO A 1 186 ? 41.08011  -19.12210 14.23494  1.000 23.52667 ? 1194 PRO A O     1 
ATOM   1447 C CB    . PRO A 1 186 ? 41.55226  -19.21445 17.42178  1.000 20.63208 ? 1194 PRO A CB    1 
ATOM   1448 C CG    . PRO A 1 186 ? 41.02242  -18.95008 18.78986  1.000 20.93589 ? 1194 PRO A CG    1 
ATOM   1449 C CD    . PRO A 1 186 ? 39.54002  -19.22109 18.67931  1.000 20.07241 ? 1194 PRO A CD    1 
ATOM   1450 N N     . ASN A 1 187 ? 39.57226  -20.51929 15.12816  1.000 16.65348 ? 1195 ASN A N     1 
ATOM   1451 C CA    . ASN A 1 187 ? 39.51206  -21.30955 13.90656  1.000 20.85843 ? 1195 ASN A CA    1 
ATOM   1452 C C     . ASN A 1 187 ? 38.43856  -20.84585 12.93176  1.000 21.78930 ? 1195 ASN A C     1 
ATOM   1453 O O     . ASN A 1 187 ? 38.27241  -21.47733 11.88308  1.000 24.50111 ? 1195 ASN A O     1 
ATOM   1454 C CB    . ASN A 1 187 ? 39.38139  -22.79034 14.23112  1.000 24.71688 ? 1195 ASN A CB    1 
ATOM   1455 C CG    . ASN A 1 187 ? 38.15901  -23.07751 15.02033  1.000 17.67368 ? 1195 ASN A CG    1 
ATOM   1456 O OD1   . ASN A 1 187 ? 38.11165  -22.74886 16.21411  1.000 23.43189 ? 1195 ASN A OD1   1 
ATOM   1457 N ND2   . ASN A 1 187 ? 37.17660  -23.72270 14.40795  1.000 23.66881 ? 1195 ASN A ND2   1 
ATOM   1458 N N     . TYR A 1 188 ? 37.72751  -19.75579 13.22930  1.000 16.70368 ? 1196 TYR A N     1 
ATOM   1459 C CA    . TYR A 1 188 ? 36.80774  -19.14564 12.26221  1.000 14.59418 ? 1196 TYR A CA    1 
ATOM   1460 C C     . TYR A 1 188 ? 36.90934  -17.62774 12.37813  1.000 13.56373 ? 1196 TYR A C     1 
ATOM   1461 O O     . TYR A 1 188 ? 36.25945  -17.01315 13.23250  1.000 13.48219 ? 1196 TYR A O     1 
ATOM   1462 C CB    . TYR A 1 188 ? 35.37412  -19.62930 12.45430  1.000 16.68282 ? 1196 TYR A CB    1 
ATOM   1463 C CG    . TYR A 1 188 ? 34.41057  -19.10523 11.40037  1.000 13.63003 ? 1196 TYR A CG    1 
ATOM   1464 C CD1   . TYR A 1 188 ? 34.52965  -19.47865 10.05849  1.000 15.27844 ? 1196 TYR A CD1   1 
ATOM   1465 C CD2   . TYR A 1 188 ? 33.38674  -18.23153 11.74659  1.000 15.98250 ? 1196 TYR A CD2   1 
ATOM   1466 C CE1   . TYR A 1 188 ? 33.62885  -18.99752 9.09397   1.000 13.07447 ? 1196 TYR A CE1   1 
ATOM   1467 C CE2   . TYR A 1 188 ? 32.49444  -17.74850 10.79279  1.000 13.50762 ? 1196 TYR A CE2   1 
ATOM   1468 C CZ    . TYR A 1 188 ? 32.62277  -18.13570 9.46354   1.000 13.10738 ? 1196 TYR A CZ    1 
ATOM   1469 O OH    . TYR A 1 188 ? 31.72199  -17.64496 8.53959   1.000 12.90086 ? 1196 TYR A OH    1 
ATOM   1470 N N     . ARG A 1 189 ? 37.71822  -17.02425 11.50148  1.000 14.07390 ? 1197 ARG A N     1 
ATOM   1471 C CA    . ARG A 1 189 ? 37.91980  -15.58107 11.45955  1.000 13.39529 ? 1197 ARG A CA    1 
ATOM   1472 C C     . ARG A 1 189 ? 37.20703  -15.08726 10.20396  1.000 14.51317 ? 1197 ARG A C     1 
ATOM   1473 O O     . ARG A 1 189 ? 37.71843  -15.22204 9.08413   1.000 15.56126 ? 1197 ARG A O     1 
ATOM   1474 C CB    . ARG A 1 189 ? 39.41523  -15.26322 11.39640  1.000 16.27296 ? 1197 ARG A CB    1 
ATOM   1475 C CG    . ARG A 1 189 ? 40.19202  -15.77563 12.58884  1.000 14.67349 ? 1197 ARG A CG    1 
ATOM   1476 C CD    . ARG A 1 189 ? 39.62762  -15.23228 13.88065  1.000 14.33288 ? 1197 ARG A CD    1 
ATOM   1477 N NE    . ARG A 1 189 ? 40.60382  -15.34731 14.96230  1.000 15.44223 ? 1197 ARG A NE    1 
ATOM   1478 C CZ    . ARG A 1 189 ? 40.33798  -15.13002 16.24192  1.000 15.62396 ? 1197 ARG A CZ    1 
ATOM   1479 N NH1   . ARG A 1 189 ? 39.13319  -14.76215 16.65200  1.000 15.92200 ? 1197 ARG A NH1   1 
ATOM   1480 N NH2   . ARG A 1 189 ? 41.31588  -15.25684 17.13977  1.000 16.82883 ? 1197 ARG A NH2   1 
ATOM   1481 N N     . PHE A 1 190 ? 36.01796  -14.53176 10.39838  1.000 13.60254 ? 1198 PHE A N     1 
ATOM   1482 C CA    . PHE A 1 190 ? 35.17476  -14.12951 9.27958   1.000 13.89888 ? 1198 PHE A CA    1 
ATOM   1483 C C     . PHE A 1 190 ? 35.65674  -12.80591 8.69885   1.000 15.15472 ? 1198 PHE A C     1 
ATOM   1484 O O     . PHE A 1 190 ? 35.76489  -11.80991 9.41922   1.000 15.97756 ? 1198 PHE A O     1 
ATOM   1485 C CB    . PHE A 1 190 ? 33.72018  -14.00555 9.74339   1.000 12.90224 ? 1198 PHE A CB    1 
ATOM   1486 C CG    . PHE A 1 190 ? 32.77759  -13.62035 8.63029   1.000 11.69011 ? 1198 PHE A CG    1 
ATOM   1487 C CD1   . PHE A 1 190 ? 32.55911  -14.48090 7.56856   1.000 13.02523 ? 1198 PHE A CD1   1 
ATOM   1488 C CD2   . PHE A 1 190 ? 32.11421  -12.40045 8.66359   1.000 13.76403 ? 1198 PHE A CD2   1 
ATOM   1489 C CE1   . PHE A 1 190 ? 31.69657  -14.11848 6.51531   1.000 11.96800 ? 1198 PHE A CE1   1 
ATOM   1490 C CE2   . PHE A 1 190 ? 31.24401  -12.03686 7.61468   1.000 12.77476 ? 1198 PHE A CE2   1 
ATOM   1491 C CZ    . PHE A 1 190 ? 31.03446  -12.90774 6.55343   1.000 13.03942 ? 1198 PHE A CZ    1 
ATOM   1492 N N     . GLY A 1 191 ? 35.90076  -12.79072 7.38437   1.000 14.95965 ? 1199 GLY A N     1 
ATOM   1493 C CA    . GLY A 1 191 ? 36.30884  -11.58016 6.69306   1.000 16.83215 ? 1199 GLY A CA    1 
ATOM   1494 C C     . GLY A 1 191 ? 35.46256  -11.24933 5.48236   1.000 18.19815 ? 1199 GLY A C     1 
ATOM   1495 O O     . GLY A 1 191 ? 35.89072  -10.46507 4.62131   1.000 16.64621 ? 1199 GLY A O     1 
ATOM   1496 N N     . GLY A 1 192 ? 34.28043  -11.85872 5.38448   1.000 14.88910 ? 1200 GLY A N     1 
ATOM   1497 C CA    . GLY A 1 192 ? 33.35346  -11.64246 4.27430   1.000 12.81299 ? 1200 GLY A CA    1 
ATOM   1498 C C     . GLY A 1 192 ? 32.34710  -10.54806 4.55931   1.000 13.10589 ? 1200 GLY A C     1 
ATOM   1499 O O     . GLY A 1 192 ? 32.61742  -9.59834  5.29926   1.000 14.58043 ? 1200 GLY A O     1 
ATOM   1500 N N     . LEU A 1 193 ? 31.15992  -10.68113 3.96059   1.000 13.30110 ? 1201 LEU A N     1 
ATOM   1501 C CA    . LEU A 1 193 ? 30.05521  -9.76081  4.18379   1.000 12.15103 ? 1201 LEU A CA    1 
ATOM   1502 C C     . LEU A 1 193 ? 28.86764  -10.54838 4.70876   1.000 11.44747 ? 1201 LEU A C     1 
ATOM   1503 O O     . LEU A 1 193 ? 28.45024  -11.53793 4.08658   1.000 12.36265 ? 1201 LEU A O     1 
ATOM   1504 C CB    . LEU A 1 193 ? 29.65515  -9.02317  2.89401   1.000 13.08410 ? 1201 LEU A CB    1 
ATOM   1505 C CG    . LEU A 1 193 ? 28.34509  -8.23097  2.94774   1.000 12.98035 ? 1201 LEU A CG    1 
ATOM   1506 C CD1   . LEU A 1 193 ? 28.36911  -7.09913  3.97611   1.000 14.41109 ? 1201 LEU A CD1   1 
ATOM   1507 C CD2   . LEU A 1 193 ? 28.01983  -7.65219  1.55091   1.000 16.11200 ? 1201 LEU A CD2   1 
ATOM   1508 N N     . ALA A 1 194 ? 28.33751  -10.11718 5.84794   1.000 11.66425 ? 1202 ALA A N     1 
ATOM   1509 C CA    . ALA A 1 194 ? 27.09751  -10.64421 6.40638   1.000 10.54556 ? 1202 ALA A CA    1 
ATOM   1510 C C     . ALA A 1 194 ? 26.04772  -9.54420  6.31581   1.000 11.27728 ? 1202 ALA A C     1 
ATOM   1511 O O     . ALA A 1 194 ? 26.28813  -8.41227  6.74989   1.000 13.33928 ? 1202 ALA A O     1 
ATOM   1512 C CB    . ALA A 1 194 ? 27.29938  -11.08630 7.86525   1.000 12.85736 ? 1202 ALA A CB    1 
ATOM   1513 N N     . TRP A 1 195 ? 24.89235  -9.84929  5.73702   1.000 10.77313 ? 1203 TRP A N     1 
ATOM   1514 C CA    . TRP A 1 195 ? 23.88037  -8.82561  5.47335   1.000 10.93503 ? 1203 TRP A CA    1 
ATOM   1515 C C     . TRP A 1 195 ? 22.54732  -9.33092  5.98783   1.000 12.07926 ? 1203 TRP A C     1 
ATOM   1516 O O     . TRP A 1 195 ? 21.98564  -10.26656 5.41063   1.000 12.32451 ? 1203 TRP A O     1 
ATOM   1517 C CB    . TRP A 1 195 ? 23.80264  -8.50865  3.97888   1.000 13.32495 ? 1203 TRP A CB    1 
ATOM   1518 C CG    . TRP A 1 195 ? 23.05215  -7.24494  3.61011   1.000 11.61535 ? 1203 TRP A CG    1 
ATOM   1519 C CD1   . TRP A 1 195 ? 22.16818  -6.54782  4.37370   1.000 12.63901 ? 1203 TRP A CD1   1 
ATOM   1520 C CD2   . TRP A 1 195 ? 23.13670  -6.54635  2.35794   1.000 11.65341 ? 1203 TRP A CD2   1 
ATOM   1521 N NE1   . TRP A 1 195 ? 21.69630  -5.45034  3.68094   1.000 13.22131 ? 1203 TRP A NE1   1 
ATOM   1522 C CE2   . TRP A 1 195 ? 22.28506  -5.42839  2.44759   1.000 10.52028 ? 1203 TRP A CE2   1 
ATOM   1523 C CE3   . TRP A 1 195 ? 23.85378  -6.76082  1.17878   1.000 13.79859 ? 1203 TRP A CE3   1 
ATOM   1524 C CZ2   . TRP A 1 195 ? 22.12241  -4.52614  1.38860   1.000 12.67416 ? 1203 TRP A CZ2   1 
ATOM   1525 C CZ3   . TRP A 1 195 ? 23.70205  -5.85423  0.13648   1.000 14.75293 ? 1203 TRP A CZ3   1 
ATOM   1526 C CH2   . TRP A 1 195 ? 22.84058  -4.75696  0.25462   1.000 13.69164 ? 1203 TRP A CH2   1 
ATOM   1527 N N     . LEU A 1 196 ? 22.04432  -8.71482  7.05652   1.000 11.09881 ? 1204 LEU A N     1 
ATOM   1528 C CA    . LEU A 1 196 ? 20.79705  -9.13085  7.68631   1.000 10.56500 ? 1204 LEU A CA    1 
ATOM   1529 C C     . LEU A 1 196 ? 19.66460  -8.20596  7.25454   1.000 12.81780 ? 1204 LEU A C     1 
ATOM   1530 O O     . LEU A 1 196 ? 19.76441  -6.97550  7.39515   1.000 12.45961 ? 1204 LEU A O     1 
ATOM   1531 C CB    . LEU A 1 196 ? 20.93585  -9.09065  9.21354   1.000 11.43380 ? 1204 LEU A CB    1 
ATOM   1532 C CG    . LEU A 1 196 ? 19.66439  -9.38263  10.01281  1.000 11.65160 ? 1204 LEU A CG    1 
ATOM   1533 C CD1   . LEU A 1 196 ? 19.17977  -10.80024 9.79018   1.000 13.61878 ? 1204 LEU A CD1   1 
ATOM   1534 C CD2   . LEU A 1 196 ? 19.92370  -9.15380  11.49652  1.000 13.36757 ? 1204 LEU A CD2   1 
ATOM   1535 N N     . PHE A 1 197 ? 18.59636  -8.80797  6.74453   1.000 13.24148 ? 1205 PHE A N     1 
ATOM   1536 C CA    . PHE A 1 197 ? 17.33813  -8.13315  6.44340   1.000 12.39756 ? 1205 PHE A CA    1 
ATOM   1537 C C     . PHE A 1 197 ? 16.28763  -8.71089  7.38277   1.000 12.45348 ? 1205 PHE A C     1 
ATOM   1538 O O     . PHE A 1 197 ? 16.12789  -9.93512  7.45532   1.000 14.51779 ? 1205 PHE A O     1 
ATOM   1539 C CB    . PHE A 1 197 ? 16.88565  -8.45647  5.01402   1.000 13.69582 ? 1205 PHE A CB    1 
ATOM   1540 C CG    . PHE A 1 197 ? 17.70080  -7.80558  3.91981   1.000 13.01395 ? 1205 PHE A CG    1 
ATOM   1541 C CD1   . PHE A 1 197 ? 18.89280  -8.37400  3.48067   1.000 12.97569 ? 1205 PHE A CD1   1 
ATOM   1542 C CD2   . PHE A 1 197 ? 17.23821  -6.65342  3.29089   1.000 15.77110 ? 1205 PHE A CD2   1 
ATOM   1543 C CE1   . PHE A 1 197 ? 19.62249  -7.80017  2.44685   1.000 14.24446 ? 1205 PHE A CE1   1 
ATOM   1544 C CE2   . PHE A 1 197 ? 17.97222  -6.06490  2.25579   1.000 15.85352 ? 1205 PHE A CE2   1 
ATOM   1545 C CZ    . PHE A 1 197 ? 19.15941  -6.63980  1.83429   1.000 15.33149 ? 1205 PHE A CZ    1 
ATOM   1546 N N     . LEU A 1 198 ? 15.56650  -7.84659  8.09290   1.000 13.70316 ? 1206 LEU A N     1 
ATOM   1547 C CA    . LEU A 1 198 ? 14.61414  -8.28965  9.10874   1.000 14.25254 ? 1206 LEU A CA    1 
ATOM   1548 C C     . LEU A 1 198 ? 13.28736  -7.57339  8.91396   1.000 15.42864 ? 1206 LEU A C     1 
ATOM   1549 O O     . LEU A 1 198 ? 13.23554  -6.33916  8.92883   1.000 16.82209 ? 1206 LEU A O     1 
ATOM   1550 C CB    . LEU A 1 198 ? 15.16252  -8.01258  10.51066  1.000 14.79516 ? 1206 LEU A CB    1 
ATOM   1551 C CG    . LEU A 1 198 ? 14.23015  -8.32266  11.68995  1.000 17.13146 ? 1206 LEU A CG    1 
ATOM   1552 C CD1   . LEU A 1 198 ? 13.82688  -9.79730  11.73851  1.000 16.37285 ? 1206 LEU A CD1   1 
ATOM   1553 C CD2   . LEU A 1 198 ? 14.87100  -7.89927  13.01520  1.000 15.13570 ? 1206 LEU A CD2   1 
ATOM   1554 N N     . GLY A 1 199 ? 12.21581  -8.34496  8.76603   1.000 14.24934 ? 1207 GLY A N     1 
ATOM   1555 C CA    . GLY A 1 199 ? 10.86584  -7.80404  8.72161   1.000 15.50876 ? 1207 GLY A CA    1 
ATOM   1556 C C     . GLY A 1 199 ? 10.10060  -8.14431  9.99061   1.000 15.74535 ? 1207 GLY A C     1 
ATOM   1557 O O     . GLY A 1 199 ? 10.04363  -9.30541  10.39871  1.000 16.24440 ? 1207 GLY A O     1 
ATOM   1558 N N     . VAL A 1 200 ? 9.50875   -7.11400  10.60065  1.000 15.87861 ? 1208 VAL A N     1 
ATOM   1559 C CA    . VAL A 1 200 ? 8.66511   -7.26983  11.78346  1.000 17.09434 ? 1208 VAL A CA    1 
ATOM   1560 C C     . VAL A 1 200 ? 7.48498   -6.31099  11.66008  1.000 21.20780 ? 1208 VAL A C     1 
ATOM   1561 O O     . VAL A 1 200 ? 7.42725   -5.47659  10.75489  1.000 20.76534 ? 1208 VAL A O     1 
ATOM   1562 C CB    . VAL A 1 200 ? 9.42317   -7.03063  13.11211  1.000 16.78964 ? 1208 VAL A CB    1 
ATOM   1563 C CG1   . VAL A 1 200 ? 10.55215  -8.06641  13.31578  1.000 16.00090 ? 1208 VAL A CG1   1 
ATOM   1564 C CG2   . VAL A 1 200 ? 9.95765   -5.61170  13.17902  1.000 17.72804 ? 1208 VAL A CG2   1 
ATOM   1565 N N     . ALA A 1 201 ? 6.54344   -6.42557  12.60662  1.000 17.49320 ? 1209 ALA A N     1 
ATOM   1566 C CA    . ALA A 1 201 ? 5.29945   -5.65729  12.51682  1.000 22.24330 ? 1209 ALA A CA    1 
ATOM   1567 C C     . ALA A 1 201 ? 5.52891   -4.16533  12.74315  1.000 21.64822 ? 1209 ALA A C     1 
ATOM   1568 O O     . ALA A 1 201 ? 4.94160   -3.33214  12.04093  1.000 25.59588 ? 1209 ALA A O     1 
ATOM   1569 C CB    . ALA A 1 201 ? 4.27209   -6.19598  13.51408  1.000 25.03596 ? 1209 ALA A CB    1 
ATOM   1570 N N     . ASN A 1 202 ? 6.33991   -3.80361  13.73455  1.000 21.04448 ? 1210 ASN A N     1 
ATOM   1571 C CA    . ASN A 1 202 ? 6.58601   -2.40838  14.08059  1.000 20.36145 ? 1210 ASN A CA    1 
ATOM   1572 C C     . ASN A 1 202 ? 7.88095   -2.32464  14.88506  1.000 21.44797 ? 1210 ASN A C     1 
ATOM   1573 O O     . ASN A 1 202 ? 8.52217   -3.34183  15.16493  1.000 19.79936 ? 1210 ASN A O     1 
ATOM   1574 C CB    . ASN A 1 202 ? 5.37488   -1.78569  14.79564  1.000 20.74064 ? 1210 ASN A CB    1 
ATOM   1575 C CG    . ASN A 1 202 ? 4.95011   -2.55254  16.04868  1.000 23.14287 ? 1210 ASN A CG    1 
ATOM   1576 O OD1   . ASN A 1 202 ? 5.73612   -3.28085  16.66003  1.000 20.49295 ? 1210 ASN A OD1   1 
ATOM   1577 N ND2   . ASN A 1 202 ? 3.68591   -2.40368  16.42311  1.000 24.32471 ? 1210 ASN A ND2   1 
ATOM   1578 N N     A SER A 1 203 ? 8.25555   -1.09932  15.26971  0.268 21.16793 ? 1211 SER A N     1 
ATOM   1579 N N     B SER A 1 203 ? 8.25534   -1.09733  15.25822  0.403 21.16896 ? 1211 SER A N     1 
ATOM   1580 N N     C SER A 1 203 ? 8.26174   -1.09516  15.25146  0.329 21.16959 ? 1211 SER A N     1 
ATOM   1581 C CA    A SER A 1 203 ? 9.51675   -0.89878  15.98234  0.268 19.75125 ? 1211 SER A CA    1 
ATOM   1582 C CA    B SER A 1 203 ? 9.50324   -0.89034  15.98745  0.403 19.71686 ? 1211 SER A CA    1 
ATOM   1583 C CA    C SER A 1 203 ? 9.50674   -0.89083  15.98880  0.329 19.73484 ? 1211 SER A CA    1 
ATOM   1584 C C     A SER A 1 203 ? 9.53728   -1.61449  17.33012  0.268 20.19398 ? 1211 SER A C     1 
ATOM   1585 C C     B SER A 1 203 ? 9.51948   -1.67020  17.29777  0.403 20.17815 ? 1211 SER A C     1 
ATOM   1586 C C     C SER A 1 203 ? 9.51679   -1.68166  17.29220  0.329 20.18456 ? 1211 SER A C     1 
ATOM   1587 O O     A SER A 1 203 ? 10.59207  -2.10104  17.75671  0.268 21.11149 ? 1211 SER A O     1 
ATOM   1588 O O     B SER A 1 203 ? 10.54226  -2.26430  17.66284  0.403 20.92450 ? 1211 SER A O     1 
ATOM   1589 O O     C SER A 1 203 ? 10.53057  -2.29738  17.64542  0.329 20.89215 ? 1211 SER A O     1 
ATOM   1590 C CB    A SER A 1 203 ? 9.80349   0.59492   16.15282  0.268 21.81815 ? 1211 SER A CB    1 
ATOM   1591 C CB    B SER A 1 203 ? 9.71737   0.60107   16.24432  0.403 21.80971 ? 1211 SER A CB    1 
ATOM   1592 C CB    C SER A 1 203 ? 9.72597   0.59934   16.26178  0.329 21.80296 ? 1211 SER A CB    1 
ATOM   1593 O OG    A SER A 1 203 ? 8.85359   1.20479   17.00810  0.268 19.62256 ? 1211 SER A OG    1 
ATOM   1594 O OG    B SER A 1 203 ? 10.99714  0.84154   16.79284  0.403 19.47365 ? 1211 SER A OG    1 
ATOM   1595 O OG    C SER A 1 203 ? 10.02689  1.30633   15.06988  0.329 23.86769 ? 1211 SER A OG    1 
ATOM   1596 N N     . ASP A 1 204 ? 8.39301   -1.69107  18.01213  1.000 19.93157 ? 1212 ASP A N     1 
ATOM   1597 C CA    . ASP A 1 204 ? 8.30764   -2.42008  19.27743  1.000 20.25784 ? 1212 ASP A CA    1 
ATOM   1598 C C     . ASP A 1 204 ? 8.43005   -3.93191  19.09467  1.000 20.62926 ? 1212 ASP A C     1 
ATOM   1599 O O     . ASP A 1 204 ? 8.62640   -4.64594  20.08479  1.000 17.82890 ? 1212 ASP A O     1 
ATOM   1600 C CB    . ASP A 1 204 ? 6.98740   -2.09175  19.98723  1.000 21.88142 ? 1212 ASP A CB    1 
ATOM   1601 C CG    . ASP A 1 204 ? 7.08158   -0.86309  20.87422  1.000 24.14592 ? 1212 ASP A CG    1 
ATOM   1602 O OD1   . ASP A 1 204 ? 8.10789   -0.14908  20.83153  1.000 24.27750 ? 1212 ASP A OD1   1 
ATOM   1603 O OD2   . ASP A 1 204 ? 6.10983   -0.60746  21.62005  1.000 23.32483 ? 1212 ASP A OD2   1 
ATOM   1604 N N     . SER A 1 205 ? 8.31352   -4.43629  17.86832  1.000 17.52313 ? 1213 SER A N     1 
ATOM   1605 C CA    . SER A 1 205 ? 8.43457   -5.86000  17.57896  1.000 15.49555 ? 1213 SER A CA    1 
ATOM   1606 C C     . SER A 1 205 ? 9.83476   -6.25318  17.12121  1.000 16.69986 ? 1213 SER A C     1 
ATOM   1607 O O     . SER A 1 205 ? 10.05679  -7.42597  16.78611  1.000 15.97707 ? 1213 SER A O     1 
ATOM   1608 C CB    . SER A 1 205 ? 7.42123   -6.27432  16.50480  1.000 18.59758 ? 1213 SER A CB    1 
ATOM   1609 O OG    . SER A 1 205 ? 6.09847   -5.93012  16.90334  1.000 17.90441 ? 1213 SER A OG    1 
ATOM   1610 N N     . LEU A 1 206 ? 10.77187  -5.31053  17.08913  1.000 13.44767 ? 1214 LEU A N     1 
ATOM   1611 C CA    . LEU A 1 206 ? 12.13859  -5.64072  16.71337  1.000 14.46661 ? 1214 LEU A CA    1 
ATOM   1612 C C     . LEU A 1 206 ? 12.76232  -6.56500  17.76009  1.000 15.63106 ? 1214 LEU A C     1 
ATOM   1613 O O     . LEU A 1 206 ? 12.42370  -6.52776  18.95129  1.000 15.29936 ? 1214 LEU A O     1 
ATOM   1614 C CB    . LEU A 1 206 ? 12.97462  -4.37479  16.56087  1.000 15.97411 ? 1214 LEU A CB    1 
ATOM   1615 C CG    . LEU A 1 206 ? 12.75655  -3.56021  15.27559  1.000 15.57332 ? 1214 LEU A CG    1 
ATOM   1616 C CD1   . LEU A 1 206 ? 13.40372  -2.19230  15.44037  1.000 19.23912 ? 1214 LEU A CD1   1 
ATOM   1617 C CD2   . LEU A 1 206 ? 13.32357  -4.29821  14.06043  1.000 18.03398 ? 1214 LEU A CD2   1 
ATOM   1618 N N     . LEU A 1 207 ? 13.66733  -7.41746  17.29569  1.000 13.96666 ? 1215 LEU A N     1 
ATOM   1619 C CA    . LEU A 1 207 ? 14.27437  -8.45212  18.12727  1.000 13.45323 ? 1215 LEU A CA    1 
ATOM   1620 C C     . LEU A 1 207 ? 15.78531  -8.30084  18.04957  1.000 11.96966 ? 1215 LEU A C     1 
ATOM   1621 O O     . LEU A 1 207 ? 16.36985  -8.38039  16.95834  1.000 13.52172 ? 1215 LEU A O     1 
ATOM   1622 C CB    . LEU A 1 207 ? 13.84150  -9.84375  17.65600  1.000 14.83645 ? 1215 LEU A CB    1 
ATOM   1623 C CG    . LEU A 1 207 ? 12.33219  -10.12080 17.53224  1.000 11.53025 ? 1215 LEU A CG    1 
ATOM   1624 C CD1   . LEU A 1 207 ? 12.07648  -11.48580 16.89165  1.000 14.01904 ? 1215 LEU A CD1   1 
ATOM   1625 C CD2   . LEU A 1 207 ? 11.59994  -10.03405 18.87281  1.000 16.19652 ? 1215 LEU A CD2   1 
ATOM   1626 N N     . TYR A 1 208 ? 16.42437  -8.07519  19.20110  1.000 12.60636 ? 1216 TYR A N     1 
ATOM   1627 C CA    . TYR A 1 208 ? 17.88399  -7.98810  19.27755  1.000 12.07174 ? 1216 TYR A CA    1 
ATOM   1628 C C     . TYR A 1 208 ? 18.44619  -6.78529  18.52309  1.000 11.72955 ? 1216 TYR A C     1 
ATOM   1629 O O     . TYR A 1 208 ? 19.60878  -6.81110  18.09803  1.000 12.99418 ? 1216 TYR A O     1 
ATOM   1630 C CB    . TYR A 1 208 ? 18.58396  -9.28887  18.82789  1.000 12.63091 ? 1216 TYR A CB    1 
ATOM   1631 C CG    . TYR A 1 208 ? 17.95515  -10.55546 19.35154  1.000 11.62785 ? 1216 TYR A CG    1 
ATOM   1632 C CD1   . TYR A 1 208 ? 18.04563  -10.89974 20.69880  1.000 13.28195 ? 1216 TYR A CD1   1 
ATOM   1633 C CD2   . TYR A 1 208 ? 17.27320  -11.41926 18.48977  1.000 11.37175 ? 1216 TYR A CD2   1 
ATOM   1634 C CE1   . TYR A 1 208 ? 17.47457  -12.06844 21.17545  1.000 12.91293 ? 1216 TYR A CE1   1 
ATOM   1635 C CE2   . TYR A 1 208 ? 16.69441  -12.59391 18.95150  1.000 11.62838 ? 1216 TYR A CE2   1 
ATOM   1636 C CZ    . TYR A 1 208 ? 16.79853  -12.91482 20.30049  1.000 11.92132 ? 1216 TYR A CZ    1 
ATOM   1637 O OH    . TYR A 1 208 ? 16.24619  -14.08013 20.77492  1.000 12.44567 ? 1216 TYR A OH    1 
ATOM   1638 N N     . ASP A 1 209 ? 17.64741  -5.72031  18.37425  1.000 12.33899 ? 1217 ASP A N     1 
ATOM   1639 C CA    . ASP A 1 209 ? 18.06191  -4.60203  17.52293  1.000 13.70235 ? 1217 ASP A CA    1 
ATOM   1640 C C     . ASP A 1 209 ? 19.35629  -3.95026  18.00325  1.000 13.41261 ? 1217 ASP A C     1 
ATOM   1641 O O     . ASP A 1 209 ? 20.21664  -3.60132  17.18938  1.000 14.77166 ? 1217 ASP A O     1 
ATOM   1642 C CB    . ASP A 1 209 ? 16.93518  -3.57883  17.41479  1.000 13.73502 ? 1217 ASP A CB    1 
ATOM   1643 C CG    . ASP A 1 209 ? 17.26568  -2.44249  16.46438  1.000 17.80172 ? 1217 ASP A CG    1 
ATOM   1644 O OD1   . ASP A 1 209 ? 17.53409  -2.71226  15.27888  1.000 16.74649 ? 1217 ASP A OD1   1 
ATOM   1645 O OD2   . ASP A 1 209 ? 17.26161  -1.27686  16.91154  1.000 18.80559 ? 1217 ASP A OD2   1 
ATOM   1646 N N     . GLU A 1 210 ? 19.52958  -3.79361  19.31969  1.000 14.92035 ? 1218 GLU A N     1 
ATOM   1647 C CA    . GLU A 1 210 ? 20.73779  -3.13948  19.81089  1.000 14.08302 ? 1218 GLU A CA    1 
ATOM   1648 C C     . GLU A 1 210 ? 21.98034  -3.96792  19.49974  1.000 15.12592 ? 1218 GLU A C     1 
ATOM   1649 O O     . GLU A 1 210 ? 23.03593  -3.41755  19.15697  1.000 14.63279 ? 1218 GLU A O     1 
ATOM   1650 C CB    . GLU A 1 210 ? 20.62249  -2.86171  21.31168  1.000 18.59441 ? 1218 GLU A CB    1 
ATOM   1651 C CG    . GLU A 1 210 ? 21.88086  -2.28228  21.92749  1.000 33.26183 ? 1218 GLU A CG    1 
ATOM   1652 C CD    . GLU A 1 210 ? 21.72366  -1.98620  23.40607  1.000 53.05652 ? 1218 GLU A CD    1 
ATOM   1653 O OE1   . GLU A 1 210 ? 20.63756  -2.26534  23.95755  1.000 58.77147 ? 1218 GLU A OE1   1 
ATOM   1654 O OE2   . GLU A 1 210 ? 22.68236  -1.46337  24.01313  1.000 62.84076 ? 1218 GLU A OE2   1 
ATOM   1655 N N     . GLU A 1 211 ? 21.87479  -5.29743  19.59680  1.000 14.01203 ? 1219 GLU A N     1 
ATOM   1656 C CA    . GLU A 1 211 ? 23.00210  -6.15910  19.25682  1.000 15.20201 ? 1219 GLU A CA    1 
ATOM   1657 C C     . GLU A 1 211 ? 23.39855  -5.98326  17.79589  1.000 12.38577 ? 1219 GLU A C     1 
ATOM   1658 O O     . GLU A 1 211 ? 24.57959  -5.80537  17.47613  1.000 12.70412 ? 1219 GLU A O     1 
ATOM   1659 C CB    . GLU A 1 211 ? 22.64466  -7.62013  19.57031  1.000 13.48315 ? 1219 GLU A CB    1 
ATOM   1660 C CG    . GLU A 1 211 ? 23.74174  -8.62461  19.26006  1.000 14.46298 ? 1219 GLU A CG    1 
ATOM   1661 C CD    . GLU A 1 211 ? 23.66143  -9.85502  20.15748  1.000 12.27646 ? 1219 GLU A CD    1 
ATOM   1662 O OE1   . GLU A 1 211 ? 23.58669  -9.65908  21.40092  1.000 14.51182 ? 1219 GLU A OE1   1 
ATOM   1663 O OE2   . GLU A 1 211 ? 23.68852  -10.98930 19.61916  1.000 11.28819 ? 1219 GLU A OE2   1 
ATOM   1664 N N     . PHE A 1 212 ? 22.41429  -6.00924  16.89513  1.000 13.82316 ? 1220 PHE A N     1 
ATOM   1665 C CA    . PHE A 1 212 ? 22.72598  -5.90402  15.47468  1.000 14.09191 ? 1220 PHE A CA    1 
ATOM   1666 C C     . PHE A 1 212 ? 23.24381  -4.51090  15.13418  1.000 14.22840 ? 1220 PHE A C     1 
ATOM   1667 O O     . PHE A 1 212 ? 24.20012  -4.37114  14.36252  1.000 14.34429 ? 1220 PHE A O     1 
ATOM   1668 C CB    . PHE A 1 212 ? 21.49313  -6.25919  14.64007  1.000 13.74926 ? 1220 PHE A CB    1 
ATOM   1669 C CG    . PHE A 1 212 ? 20.97559  -7.65078  14.87805  1.000 12.47177 ? 1220 PHE A CG    1 
ATOM   1670 C CD1   . PHE A 1 212 ? 21.85100  -8.70961  15.09136  1.000 14.67680 ? 1220 PHE A CD1   1 
ATOM   1671 C CD2   . PHE A 1 212 ? 19.61390  -7.89809  14.89602  1.000 12.98530 ? 1220 PHE A CD2   1 
ATOM   1672 C CE1   . PHE A 1 212 ? 21.38069  -10.00173 15.31266  1.000 12.80088 ? 1220 PHE A CE1   1 
ATOM   1673 C CE2   . PHE A 1 212 ? 19.11557  -9.18185  15.11679  1.000 13.06154 ? 1220 PHE A CE2   1 
ATOM   1674 C CZ    . PHE A 1 212 ? 20.00852  -10.24863 15.33459  1.000 13.60263 ? 1220 PHE A CZ    1 
ATOM   1675 N N     . THR A 1 213 ? 22.64390  -3.47099  15.72136  1.000 13.89660 ? 1221 THR A N     1 
ATOM   1676 C CA    . THR A 1 213 ? 23.13379  -2.11616  15.48834  1.000 16.55271 ? 1221 THR A CA    1 
ATOM   1677 C C     . THR A 1 213 ? 24.58413  -1.97516  15.94597  1.000 17.38841 ? 1221 THR A C     1 
ATOM   1678 O O     . THR A 1 213 ? 25.38029  -1.27296  15.31156  1.000 19.04587 ? 1221 THR A O     1 
ATOM   1679 C CB    . THR A 1 213 ? 22.20359  -1.09433  16.15214  1.000 15.85982 ? 1221 THR A CB    1 
ATOM   1680 O OG1   . THR A 1 213 ? 20.90092  -1.18868  15.56392  1.000 20.33519 ? 1221 THR A OG1   1 
ATOM   1681 C CG2   . THR A 1 213 ? 22.72979  0.32781   15.95281  1.000 22.75887 ? 1221 THR A CG2   1 
ATOM   1682 N N     A SER A 1 214 ? 24.95350  -2.66269  17.03183  0.449 16.76332 ? 1222 SER A N     1 
ATOM   1683 N N     B SER A 1 214 ? 24.95699  -2.65382  17.03115  0.323 16.75969 ? 1222 SER A N     1 
ATOM   1684 N N     C SER A 1 214 ? 24.95312  -2.65702  17.03162  0.227 16.75840 ? 1222 SER A N     1 
ATOM   1685 C CA    A SER A 1 214 ? 26.33028  -2.59844  17.51737  0.449 16.82304 ? 1222 SER A CA    1 
ATOM   1686 C CA    B SER A 1 214 ? 26.33614  -2.55996  17.49848  0.323 16.79029 ? 1222 SER A CA    1 
ATOM   1687 C CA    C SER A 1 214 ? 26.32939  -2.57854  17.50753  0.227 16.79899 ? 1222 SER A CA    1 
ATOM   1688 C C     A SER A 1 214 ? 27.31106  -3.14839  16.48703  0.449 16.06291 ? 1222 SER A C     1 
ATOM   1689 C C     B SER A 1 214 ? 27.32060  -3.15795  16.49675  0.323 16.06807 ? 1222 SER A C     1 
ATOM   1690 C C     C SER A 1 214 ? 27.31209  -3.15042  16.49108  0.227 16.07180 ? 1222 SER A C     1 
ATOM   1691 O O     A SER A 1 214 ? 28.42656  -2.63278  16.34122  0.449 16.11550 ? 1222 SER A O     1 
ATOM   1692 O O     B SER A 1 214 ? 28.45336  -2.67522  16.38192  0.323 16.12448 ? 1222 SER A O     1 
ATOM   1693 O O     C SER A 1 214 ? 28.43438  -2.64692  16.36371  0.227 16.13496 ? 1222 SER A O     1 
ATOM   1694 C CB    A SER A 1 214 ? 26.45785  -3.34094  18.85396  0.449 15.23407 ? 1222 SER A CB    1 
ATOM   1695 C CB    B SER A 1 214 ? 26.47098  -3.19952  18.88141  0.323 15.24349 ? 1222 SER A CB    1 
ATOM   1696 C CB    C SER A 1 214 ? 26.46094  -3.28557  18.85697  0.227 15.27582 ? 1222 SER A CB    1 
ATOM   1697 O OG    A SER A 1 214 ? 26.50380  -4.75215  18.67878  0.449 15.32183 ? 1222 SER A OG    1 
ATOM   1698 O OG    B SER A 1 214 ? 25.74896  -2.44875  19.84329  0.323 18.69909 ? 1222 SER A OG    1 
ATOM   1699 O OG    C SER A 1 214 ? 27.80229  -3.26850  19.30570  0.227 17.58804 ? 1222 SER A OG    1 
ATOM   1700 N N     . TYR A 1 215 ? 26.91147  -4.18840  15.74910  1.000 13.40520 ? 1223 TYR A N     1 
ATOM   1701 C CA    . TYR A 1 215 ? 27.79318  -4.73696  14.72365  1.000 13.54472 ? 1223 TYR A CA    1 
ATOM   1702 C C     . TYR A 1 215 ? 28.05120  -3.72896  13.60293  1.000 13.55233 ? 1223 TYR A C     1 
ATOM   1703 O O     . TYR A 1 215 ? 29.14114  -3.72778  13.02087  1.000 14.51657 ? 1223 TYR A O     1 
ATOM   1704 C CB    . TYR A 1 215 ? 27.20898  -6.01783  14.12756  1.000 14.08359 ? 1223 TYR A CB    1 
ATOM   1705 C CG    . TYR A 1 215 ? 27.05589  -7.20367  15.05836  1.000 11.63475 ? 1223 TYR A CG    1 
ATOM   1706 C CD1   . TYR A 1 215 ? 27.99117  -7.50352  16.03211  1.000 12.69732 ? 1223 TYR A CD1   1 
ATOM   1707 C CD2   . TYR A 1 215 ? 25.96699  -8.05693  14.90645  1.000 12.20392 ? 1223 TYR A CD2   1 
ATOM   1708 C CE1   . TYR A 1 215 ? 27.82921  -8.62204  16.84816  1.000 13.47252 ? 1223 TYR A CE1   1 
ATOM   1709 C CE2   . TYR A 1 215 ? 25.79543  -9.15995  15.70803  1.000 11.66580 ? 1223 TYR A CE2   1 
ATOM   1710 C CZ    . TYR A 1 215 ? 26.72593  -9.42917  16.68113  1.000 11.51508 ? 1223 TYR A CZ    1 
ATOM   1711 O OH    . TYR A 1 215 ? 26.56918  -10.54696 17.49052  1.000 12.05958 ? 1223 TYR A OH    1 
ATOM   1712 N N     . LEU A 1 216 ? 27.07860  -2.86111  13.29961  1.000 13.59869 ? 1224 LEU A N     1 
ATOM   1713 C CA    . LEU A 1 216 ? 27.31627  -1.83294  12.28189  1.000 14.48360 ? 1224 LEU A CA    1 
ATOM   1714 C C     . LEU A 1 216 ? 28.45945  -0.91240  12.67119  1.000 15.62528 ? 1224 LEU A C     1 
ATOM   1715 O O     . LEU A 1 216 ? 29.20354  -0.44986  11.80231  1.000 17.14493 ? 1224 LEU A O     1 
ATOM   1716 C CB    . LEU A 1 216 ? 26.05992  -1.00287  12.04037  1.000 16.63220 ? 1224 LEU A CB    1 
ATOM   1717 C CG    . LEU A 1 216 ? 24.90542  -1.65455  11.28135  1.000 18.09124 ? 1224 LEU A CG    1 
ATOM   1718 C CD1   . LEU A 1 216 ? 23.68922  -0.76619  11.34583  1.000 16.44833 ? 1224 LEU A CD1   1 
ATOM   1719 C CD2   . LEU A 1 216 ? 25.28535  -1.91581  9.82224   1.000 14.51381 ? 1224 LEU A CD2   1 
ATOM   1720 N N     . LYS A 1 217 ? 28.62100  -0.63888  13.96407  1.000 15.22049 ? 1225 LYS A N     1 
ATOM   1721 C CA    . LYS A 1 217 ? 29.66737  0.26528   14.42708  1.000 17.47833 ? 1225 LYS A CA    1 
ATOM   1722 C C     . LYS A 1 217 ? 31.00237  -0.42984  14.63310  1.000 19.02685 ? 1225 LYS A C     1 
ATOM   1723 O O     . LYS A 1 217 ? 32.05388  0.21174   14.52660  1.000 20.79395 ? 1225 LYS A O     1 
ATOM   1724 C CB    . LYS A 1 217 ? 29.22477  0.97050   15.71615  1.000 20.00837 ? 1225 LYS A CB    1 
ATOM   1725 C CG    . LYS A 1 217 ? 28.13515  2.01529   15.47561  1.000 27.54477 ? 1225 LYS A CG    1 
ATOM   1726 C CD    . LYS A 1 217 ? 26.77324  1.61981   16.04348  1.000 35.68960 ? 1225 LYS A CD    1 
ATOM   1727 C CE    . LYS A 1 217 ? 26.74635  1.72213   17.57265  1.000 41.02824 ? 1225 LYS A CE    1 
ATOM   1728 N NZ    . LYS A 1 217 ? 25.68916  0.86694   18.22360  1.000 37.79151 ? 1225 LYS A NZ    1 
ATOM   1729 N N     . GLN A 1 218 ? 30.99261  -1.72596  14.91955  1.000 14.42659 ? 1226 GLN A N     1 
ATOM   1730 C CA    . GLN A 1 218 ? 32.22754  -2.46021  15.14133  1.000 15.64062 ? 1226 GLN A CA    1 
ATOM   1731 C C     . GLN A 1 218 ? 32.79114  -3.07621  13.87318  1.000 13.68559 ? 1226 GLN A C     1 
ATOM   1732 O O     . GLN A 1 218 ? 34.01366  -3.17512  13.73463  1.000 17.24122 ? 1226 GLN A O     1 
ATOM   1733 C CB    . GLN A 1 218 ? 32.00697  -3.56581  16.17878  1.000 18.10621 ? 1226 GLN A CB    1 
ATOM   1734 C CG    . GLN A 1 218 ? 31.37356  -3.08618  17.47271  1.000 23.61834 ? 1226 GLN A CG    1 
ATOM   1735 C CD    . GLN A 1 218 ? 31.02865  -4.23237  18.41660  1.000 31.37167 ? 1226 GLN A CD    1 
ATOM   1736 O OE1   . GLN A 1 218 ? 30.57946  -4.00913  19.54341  1.000 35.72625 ? 1226 GLN A OE1   1 
ATOM   1737 N NE2   . GLN A 1 218 ? 31.20182  -5.46471  17.94321  1.000 34.28522 ? 1226 GLN A NE2   1 
ATOM   1738 N N     . TYR A 1 219 ? 31.92402  -3.48825  12.94272  1.000 14.39444 ? 1227 TYR A N     1 
ATOM   1739 C CA    . TYR A 1 219 ? 32.34640  -4.14502  11.70415  1.000 16.78395 ? 1227 TYR A CA    1 
ATOM   1740 C C     . TYR A 1 219 ? 31.68175  -3.48539  10.49696  1.000 16.22967 ? 1227 TYR A C     1 
ATOM   1741 O O     . TYR A 1 219 ? 30.98621  -4.14455  9.71353   1.000 13.86517 ? 1227 TYR A O     1 
ATOM   1742 C CB    . TYR A 1 219 ? 32.03346  -5.64000  11.76991  1.000 14.91409 ? 1227 TYR A CB    1 
ATOM   1743 C CG    . TYR A 1 219 ? 32.82923  -6.33792  12.85476  1.000 14.98971 ? 1227 TYR A CG    1 
ATOM   1744 C CD1   . TYR A 1 219 ? 34.12010  -6.78060  12.62038  1.000 18.65998 ? 1227 TYR A CD1   1 
ATOM   1745 C CD2   . TYR A 1 219 ? 32.29963  -6.50019  14.12739  1.000 14.43423 ? 1227 TYR A CD2   1 
ATOM   1746 C CE1   . TYR A 1 219 ? 34.86080  -7.40233  13.62590  1.000 19.33588 ? 1227 TYR A CE1   1 
ATOM   1747 C CE2   . TYR A 1 219 ? 33.03040  -7.11957  15.13527  1.000 18.02418 ? 1227 TYR A CE2   1 
ATOM   1748 C CZ    . TYR A 1 219 ? 34.30053  -7.56315  14.87058  1.000 16.48888 ? 1227 TYR A CZ    1 
ATOM   1749 O OH    . TYR A 1 219 ? 35.02462  -8.17313  15.88406  1.000 24.39252 ? 1227 TYR A OH    1 
ATOM   1750 N N     . PRO A 1 220 ? 31.90251  -2.18024  10.29470  1.000 14.98200 ? 1228 PRO A N     1 
ATOM   1751 C CA    . PRO A 1 220 ? 31.16494  -1.46932  9.23194   1.000 14.86782 ? 1228 PRO A CA    1 
ATOM   1752 C C     . PRO A 1 220 ? 31.47302  -1.95182  7.82895   1.000 14.42976 ? 1228 PRO A C     1 
ATOM   1753 O O     . PRO A 1 220 ? 30.66542  -1.69380  6.91949   1.000 14.97972 ? 1228 PRO A O     1 
ATOM   1754 C CB    . PRO A 1 220 ? 31.58100  0.00023   9.43213   1.000 14.97943 ? 1228 PRO A CB    1 
ATOM   1755 C CG    . PRO A 1 220 ? 32.94568  -0.09389  10.05116  1.000 16.02834 ? 1228 PRO A CG    1 
ATOM   1756 C CD    . PRO A 1 220 ? 32.86504  -1.29217  10.98128  1.000 16.30980 ? 1228 PRO A CD    1 
ATOM   1757 N N     . ASP A 1 221 ? 32.59542  -2.62478  7.60995   1.000 13.43754 ? 1229 ASP A N     1 
ATOM   1758 C CA    . ASP A 1 221 ? 32.93012  -3.14231  6.29396   1.000 16.70188 ? 1229 ASP A CA    1 
ATOM   1759 C C     . ASP A 1 221 ? 32.58926  -4.61392  6.12559   1.000 14.43895 ? 1229 ASP A C     1 
ATOM   1760 O O     . ASP A 1 221 ? 32.82841  -5.17406  5.04602   1.000 16.22543 ? 1229 ASP A O     1 
ATOM   1761 C CB    . ASP A 1 221 ? 34.40506  -2.91603  5.96627   1.000 15.97357 ? 1229 ASP A CB    1 
ATOM   1762 C CG    . ASP A 1 221 ? 34.62378  -2.61245  4.49267   1.000 25.13181 ? 1229 ASP A CG    1 
ATOM   1763 O OD1   . ASP A 1 221 ? 33.81956  -1.83930  3.91173   1.000 24.38616 ? 1229 ASP A OD1   1 
ATOM   1764 O OD2   . ASP A 1 221 ? 35.58889  -3.15908  3.92878   1.000 33.36648 ? 1229 ASP A OD2   1 
ATOM   1765 N N     . ASN A 1 222 ? 32.04305  -5.25769  7.15477   1.000 13.31274 ? 1230 ASN A N     1 
ATOM   1766 C CA    . ASN A 1 222 ? 31.69259  -6.67040  7.06413   1.000 12.79367 ? 1230 ASN A CA    1 
ATOM   1767 C C     . ASN A 1 222 ? 30.24132  -6.97246  7.40605   1.000 12.18479 ? 1230 ASN A C     1 
ATOM   1768 O O     . ASN A 1 222 ? 29.82419  -8.13071  7.25503   1.000 13.17183 ? 1230 ASN A O     1 
ATOM   1769 C CB    . ASN A 1 222 ? 32.60816  -7.52396  7.95564   1.000 14.91624 ? 1230 ASN A CB    1 
ATOM   1770 C CG    . ASN A 1 222 ? 34.07702  -7.32611  7.64069   1.000 15.52928 ? 1230 ASN A CG    1 
ATOM   1771 O OD1   . ASN A 1 222 ? 34.74050  -6.47921  8.25214   1.000 17.97690 ? 1230 ASN A OD1   1 
ATOM   1772 N ND2   . ASN A 1 222 ? 34.59579  -8.09021  6.70203   1.000 16.03589 ? 1230 ASN A ND2   1 
ATOM   1773 N N     . PHE A 1 223 ? 29.46256  -5.98866  7.84998   1.000 12.14380 ? 1231 PHE A N     1 
ATOM   1774 C CA    . PHE A 1 223 ? 28.08662  -6.22052  8.27500   1.000 10.70758 ? 1231 PHE A CA    1 
ATOM   1775 C C     . PHE A 1 223 ? 27.18494  -5.11688  7.74088   1.000 13.61137 ? 1231 PHE A C     1 
ATOM   1776 O O     . PHE A 1 223 ? 27.51281  -3.93307  7.87469   1.000 15.29999 ? 1231 PHE A O     1 
ATOM   1777 C CB    . PHE A 1 223 ? 27.96468  -6.26752  9.81111   1.000 13.24373 ? 1231 PHE A CB    1 
ATOM   1778 C CG    . PHE A 1 223 ? 26.55425  -6.52503  10.29788  1.000 11.95623 ? 1231 PHE A CG    1 
ATOM   1779 C CD1   . PHE A 1 223 ? 25.92570  -7.74887  9.99824   1.000 12.21231 ? 1231 PHE A CD1   1 
ATOM   1780 C CD2   . PHE A 1 223 ? 25.85005  -5.56936  11.02965  1.000 11.62246 ? 1231 PHE A CD2   1 
ATOM   1781 C CE1   . PHE A 1 223 ? 24.61915  -7.99997  10.43095  1.000 13.21960 ? 1231 PHE A CE1   1 
ATOM   1782 C CE2   . PHE A 1 223 ? 24.53804  -5.81954  11.47604  1.000 13.13542 ? 1231 PHE A CE2   1 
ATOM   1783 C CZ    . PHE A 1 223 ? 23.92414  -7.05236  11.17071  1.000 13.92807 ? 1231 PHE A CZ    1 
ATOM   1784 N N     . ARG A 1 224 ? 26.03585  -5.50456  7.17234   1.000 12.21390 ? 1232 ARG A N     1 
ATOM   1785 C CA    . ARG A 1 224 ? 24.97461  -4.58599  6.79559   1.000 13.13764 ? 1232 ARG A CA    1 
ATOM   1786 C C     . ARG A 1 224 ? 23.66611  -5.06585  7.40237   1.000 13.33742 ? 1232 ARG A C     1 
ATOM   1787 O O     . ARG A 1 224 ? 23.50227  -6.25685  7.67725   1.000 12.71901 ? 1232 ARG A O     1 
ATOM   1788 C CB    . ARG A 1 224 ? 24.86835  -4.46901  5.26149   1.000 12.20976 ? 1232 ARG A CB    1 
ATOM   1789 C CG    . ARG A 1 224 ? 26.11631  -3.81172  4.65942   1.000 12.56544 ? 1232 ARG A CG    1 
ATOM   1790 C CD    . ARG A 1 224 ? 26.12463  -3.86416  3.14868   1.000 16.33336 ? 1232 ARG A CD    1 
ATOM   1791 N NE    . ARG A 1 224 ? 25.13141  -2.96718  2.57198   1.000 16.03157 ? 1232 ARG A NE    1 
ATOM   1792 C CZ    . ARG A 1 224 ? 25.14456  -2.57086  1.30723   1.000 19.26376 ? 1232 ARG A CZ    1 
ATOM   1793 N NH1   . ARG A 1 224 ? 26.09346  -2.96502  0.47759   1.000 18.12071 ? 1232 ARG A NH1   1 
ATOM   1794 N NH2   . ARG A 1 224 ? 24.17652  -1.76950  0.87193   1.000 17.76117 ? 1232 ARG A NH2   1 
ATOM   1795 N N     . TYR A 1 225 ? 22.73686  -4.13820  7.62037   1.000 13.40374 ? 1233 TYR A N     1 
ATOM   1796 C CA    . TYR A 1 225 ? 21.53284  -4.41646  8.40532   1.000 12.55669 ? 1233 TYR A CA    1 
ATOM   1797 C C     . TYR A 1 225 ? 20.41511  -3.51116  7.90948   1.000 13.43123 ? 1233 TYR A C     1 
ATOM   1798 O O     . TYR A 1 225 ? 20.55630  -2.28161  7.96923   1.000 16.05101 ? 1233 TYR A O     1 
ATOM   1799 C CB    . TYR A 1 225 ? 21.84287  -4.13017  9.87875   1.000 13.84110 ? 1233 TYR A CB    1 
ATOM   1800 C CG    . TYR A 1 225 ? 20.74644  -4.33612  10.89965  1.000 13.18122 ? 1233 TYR A CG    1 
ATOM   1801 C CD1   . TYR A 1 225 ? 19.81869  -5.36084  10.78931  1.000 13.61985 ? 1233 TYR A CD1   1 
ATOM   1802 C CD2   . TYR A 1 225 ? 20.66616  -3.49397  12.00760  1.000 14.55695 ? 1233 TYR A CD2   1 
ATOM   1803 C CE1   . TYR A 1 225 ? 18.82914  -5.54343  11.76901  1.000 12.81091 ? 1233 TYR A CE1   1 
ATOM   1804 C CE2   . TYR A 1 225 ? 19.69659  -3.66057  12.97922  1.000 13.89110 ? 1233 TYR A CE2   1 
ATOM   1805 C CZ    . TYR A 1 225 ? 18.78711  -4.69201  12.86531  1.000 13.15268 ? 1233 TYR A CZ    1 
ATOM   1806 O OH    . TYR A 1 225 ? 17.81896  -4.86022  13.83685  1.000 14.27886 ? 1233 TYR A OH    1 
ATOM   1807 N N     . ASP A 1 226 ? 19.30120  -4.10674  7.46099   1.000 13.17307 ? 1234 ASP A N     1 
ATOM   1808 C CA    . ASP A 1 226 ? 18.15421  -3.35189  6.95677   1.000 12.31541 ? 1234 ASP A CA    1 
ATOM   1809 C C     . ASP A 1 226 ? 16.85549  -3.93635  7.49378   1.000 14.39838 ? 1234 ASP A C     1 
ATOM   1810 O O     . ASP A 1 226 ? 16.68537  -5.15866  7.53136   1.000 15.55520 ? 1234 ASP A O     1 
ATOM   1811 C CB    . ASP A 1 226 ? 18.13190  -3.35607  5.41955   1.000 14.93058 ? 1234 ASP A CB    1 
ATOM   1812 C CG    . ASP A 1 226 ? 19.22062  -2.48898  4.81803   1.000 14.32385 ? 1234 ASP A CG    1 
ATOM   1813 O OD1   . ASP A 1 226 ? 19.04024  -1.24968  4.77782   1.000 17.63685 ? 1234 ASP A OD1   1 
ATOM   1814 O OD2   . ASP A 1 226 ? 20.25642  -3.03484  4.40736   1.000 14.51135 ? 1234 ASP A OD2   1 
ATOM   1815 N N     . LYS A 1 227 ? 15.93362  -3.06374  7.90932   1.000 15.67912 ? 1235 LYS A N     1 
ATOM   1816 C CA    . LYS A 1 227 ? 14.69632  -3.47147  8.56068   1.000 15.01989 ? 1235 LYS A CA    1 
ATOM   1817 C C     . LYS A 1 227 ? 13.47101  -2.97655  7.79624   1.000 18.04204 ? 1235 LYS A C     1 
ATOM   1818 O O     . LYS A 1 227 ? 13.49080  -1.89749  7.19497   1.000 20.64673 ? 1235 LYS A O     1 
ATOM   1819 C CB    . LYS A 1 227 ? 14.63404  -2.88182  9.98437   1.000 16.58848 ? 1235 LYS A CB    1 
ATOM   1820 C CG    . LYS A 1 227 ? 15.65482  -3.49749  10.95643  1.000 15.34367 ? 1235 LYS A CG    1 
ATOM   1821 C CD    . LYS A 1 227 ? 15.87183  -2.60444  12.18191  1.000 17.98140 ? 1235 LYS A CD    1 
ATOM   1822 C CE    . LYS A 1 227 ? 16.92670  -1.54936  11.93576  1.000 18.82285 ? 1235 LYS A CE    1 
ATOM   1823 N NZ    . LYS A 1 227 ? 17.14662  -0.75820  13.17796  1.000 19.33573 ? 1235 LYS A NZ    1 
ATOM   1824 N N     A ALA A 1 228 ? 12.40101  -3.78331  7.83862   0.550 16.57319 ? 1236 ALA A N     1 
ATOM   1825 N N     B ALA A 1 228 ? 12.40198  -3.76061  7.85278   0.450 16.59971 ? 1236 ALA A N     1 
ATOM   1826 C CA    A ALA A 1 228 ? 11.10358  -3.47072  7.24127   0.550 16.46889 ? 1236 ALA A CA    1 
ATOM   1827 C CA    B ALA A 1 228 ? 11.08384  -3.32984  7.41171   0.450 16.74162 ? 1236 ALA A CA    1 
ATOM   1828 C C     A ALA A 1 228 ? 10.01329  -3.67651  8.28542   0.550 16.06619 ? 1236 ALA A C     1 
ATOM   1829 C C     B ALA A 1 228 ? 10.18816  -3.26754  8.63811   0.450 19.18797 ? 1236 ALA A C     1 
ATOM   1830 O O     A ALA A 1 228 ? 9.91768   -4.75670  8.87490   0.550 15.06068 ? 1236 ALA A O     1 
ATOM   1831 O O     B ALA A 1 228 ? 10.00768  -4.27656  9.32746   0.450 18.82164 ? 1236 ALA A O     1 
ATOM   1832 C CB    A ALA A 1 228 ? 10.83263  -4.38246  6.04224   0.550 18.78008 ? 1236 ALA A CB    1 
ATOM   1833 C CB    B ALA A 1 228 ? 10.51200  -4.30979  6.39055   0.450 18.86554 ? 1236 ALA A CB    1 
ATOM   1834 N N     A LEU A 1 229 ? 9.17233   -2.65448  8.48349   0.550 17.66458 ? 1237 LEU A N     1 
ATOM   1835 N N     B LEU A 1 229 ? 9.65961   -2.08324  8.92614   0.450 17.57559 ? 1237 LEU A N     1 
ATOM   1836 C CA    A LEU A 1 229 ? 8.23235   -2.56309  9.60574   0.550 15.91462 ? 1237 LEU A CA    1 
ATOM   1837 C CA    B LEU A 1 229 ? 8.63319   -1.90409  9.95016   0.450 20.57431 ? 1237 LEU A CA    1 
ATOM   1838 C C     A LEU A 1 229 ? 6.83619   -2.49848  8.98803   0.550 18.69777 ? 1237 LEU A C     1 
ATOM   1839 C C     B LEU A 1 229 ? 7.34798   -1.63731  9.17367   0.450 19.80370 ? 1237 LEU A C     1 
ATOM   1840 O O     A LEU A 1 229 ? 6.40718   -1.43068  8.53004   0.550 19.69559 ? 1237 LEU A O     1 
ATOM   1841 O O     B LEU A 1 229 ? 7.03876   -0.49600  8.82782   0.450 21.69701 ? 1237 LEU A O     1 
ATOM   1842 C CB    A LEU A 1 229 ? 8.50762   -1.28748  10.39716  0.550 20.13383 ? 1237 LEU A CB    1 
ATOM   1843 C CB    B LEU A 1 229 ? 8.98290   -0.75089  10.88525  0.450 19.21730 ? 1237 LEU A CB    1 
ATOM   1844 C CG    A LEU A 1 229 ? 9.87878   -1.19406  11.06896  0.550 15.65281 ? 1237 LEU A CG    1 
ATOM   1845 C CG    B LEU A 1 229 ? 10.43302  -0.69452  11.36941  0.450 20.24366 ? 1237 LEU A CG    1 
ATOM   1846 C CD1   A LEU A 1 229 ? 10.08917  0.17280   11.71496  0.550 26.03227 ? 1237 LEU A CD1   1 
ATOM   1847 C CD1   B LEU A 1 229 ? 10.62688  0.47396   12.33336  0.450 22.23036 ? 1237 LEU A CD1   1 
ATOM   1848 C CD2   A LEU A 1 229 ? 10.10129  -2.31000  12.06357  0.550 17.97659 ? 1237 LEU A CD2   1 
ATOM   1849 C CD2   B LEU A 1 229 ? 10.85804  -2.01664  12.00571  0.450 17.11334 ? 1237 LEU A CD2   1 
ATOM   1850 N N     A SER A 1 230 ? 6.11085   -3.62319  8.99461   0.550 17.49096 ? 1238 SER A N     1 
ATOM   1851 N N     B SER A 1 230 ? 6.60705   -2.71066  8.88531   0.450 18.27595 ? 1238 SER A N     1 
ATOM   1852 C CA    A SER A 1 230 ? 4.98395   -3.77811  8.07191   0.550 19.88720 ? 1238 SER A CA    1 
ATOM   1853 C CA    B SER A 1 230 ? 5.50699   -2.62289  7.92920   0.450 18.73981 ? 1238 SER A CA    1 
ATOM   1854 C C     A SER A 1 230 ? 3.78992   -2.90149  8.43087   0.550 19.60344 ? 1238 SER A C     1 
ATOM   1855 C C     B SER A 1 230 ? 4.40143   -1.67560  8.37514   0.450 22.56523 ? 1238 SER A C     1 
ATOM   1856 O O     A SER A 1 230 ? 3.03748   -2.49203  7.53639   0.550 21.10854 ? 1238 SER A O     1 
ATOM   1857 O O     B SER A 1 230 ? 3.63074   -1.20719  7.52919   0.450 24.38402 ? 1238 SER A O     1 
ATOM   1858 C CB    A SER A 1 230 ? 4.55918   -5.24383  7.97017   0.550 20.46858 ? 1238 SER A CB    1 
ATOM   1859 C CB    B SER A 1 230 ? 4.93133   -4.01288  7.65447   0.450 20.86639 ? 1238 SER A CB    1 
ATOM   1860 O OG    A SER A 1 230 ? 3.93545   -5.67105  9.16685   0.550 22.24719 ? 1238 SER A OG    1 
ATOM   1861 O OG    B SER A 1 230 ? 4.31814   -4.54866  8.81431   0.450 22.88779 ? 1238 SER A OG    1 
ATOM   1862 N N     A ARG A 1 231 ? 3.58913   -2.60730  9.70839   0.550 20.74180 ? 1239 ARG A N     1 
ATOM   1863 N N     B ARG A 1 231 ? 4.30951   -1.37349  9.67174   0.450 19.13540 ? 1239 ARG A N     1 
ATOM   1864 C CA    A ARG A 1 231 ? 2.46170   -1.78389  10.12048  0.550 21.31781 ? 1239 ARG A CA    1 
ATOM   1865 C CA    B ARG A 1 231 ? 3.24949   -0.52174  10.19378  0.450 22.41506 ? 1239 ARG A CA    1 
ATOM   1866 C C     A ARG A 1 231 ? 2.80606   -0.30364  10.21501  0.550 23.42750 ? 1239 ARG A C     1 
ATOM   1867 C C     B ARG A 1 231 ? 3.65604   0.93767   10.35906  0.450 22.63573 ? 1239 ARG A C     1 
ATOM   1868 O O     A ARG A 1 231 ? 1.90506   0.51572   10.43199  0.550 24.33040 ? 1239 ARG A O     1 
ATOM   1869 O O     B ARG A 1 231 ? 2.80086   1.75834   10.70205  0.450 24.57454 ? 1239 ARG A O     1 
ATOM   1870 C CB    A ARG A 1 231 ? 1.89697   -2.29138  11.45078  0.550 24.15135 ? 1239 ARG A CB    1 
ATOM   1871 C CB    B ARG A 1 231 ? 2.74782   -1.05524  11.54285  0.450 21.50908 ? 1239 ARG A CB    1 
ATOM   1872 C CG    A ARG A 1 231 ? 1.37364   -3.71556  11.36900  0.550 23.65361 ? 1239 ARG A CG    1 
ATOM   1873 C CG    B ARG A 1 231 ? 1.97272   -2.35703  11.46900  0.450 24.10777 ? 1239 ARG A CG    1 
ATOM   1874 C CD    A ARG A 1 231 ? 0.73372   -4.17116  12.66732  0.550 27.66585 ? 1239 ARG A CD    1 
ATOM   1875 C CD    B ARG A 1 231 ? 1.50680   -2.76629  12.85604  0.450 26.76699 ? 1239 ARG A CD    1 
ATOM   1876 N NE    A ARG A 1 231 ? 0.34108   -5.57345  12.60138  0.550 23.10508 ? 1239 ARG A NE    1 
ATOM   1877 N NE    B ARG A 1 231 ? 0.82375   -4.05296  12.86516  0.450 27.85218 ? 1239 ARG A NE    1 
ATOM   1878 C CZ    A ARG A 1 231 ? -0.47676  -6.16628  13.45973  0.550 29.94084 ? 1239 ARG A CZ    1 
ATOM   1879 C CZ    B ARG A 1 231 ? -0.00219  -4.45033  13.82245  0.450 22.86040 ? 1239 ARG A CZ    1 
ATOM   1880 N NH1   A ARG A 1 231 ? -1.01009  -5.50600  14.47551  0.550 25.10595 ? 1239 ARG A NH1   1 
ATOM   1881 N NH1   B ARG A 1 231 ? -0.26459  -3.68570  14.87079  0.450 30.35846 ? 1239 ARG A NH1   1 
ATOM   1882 N NH2   A ARG A 1 231 ? -0.76582  -7.45379  13.29544  0.550 31.79980 ? 1239 ARG A NH2   1 
ATOM   1883 N NH2   B ARG A 1 231 ? -0.56821  -5.64988  13.73394  0.450 29.17225 ? 1239 ARG A NH2   1 
ATOM   1884 N N     A GLU A 1 232 ? 4.07440   0.05922   10.03431  0.550 18.48756 ? 1240 GLU A N     1 
ATOM   1885 N N     B GLU A 1 232 ? 4.92658   1.28859   10.14065  0.450 22.82303 ? 1240 GLU A N     1 
ATOM   1886 C CA    A GLU A 1 232 ? 4.51969   1.43413   10.17558  0.550 22.84872 ? 1240 GLU A CA    1 
ATOM   1887 C CA    B GLU A 1 232 ? 5.33767   2.67862   10.31154  0.450 22.99709 ? 1240 GLU A CA    1 
ATOM   1888 C C     A GLU A 1 232 ? 5.14530   1.98344   8.90023   0.550 20.16404 ? 1240 GLU A C     1 
ATOM   1889 C C     B GLU A 1 232 ? 6.27671   3.19581   9.22522   0.450 22.25598 ? 1240 GLU A C     1 
ATOM   1890 O O     A GLU A 1 232 ? 5.46687   3.17823   8.85179   0.550 23.54445 ? 1240 GLU A O     1 
ATOM   1891 O O     B GLU A 1 232 ? 6.74852   4.33589   9.33302   0.450 22.94758 ? 1240 GLU A O     1 
ATOM   1892 C CB    A GLU A 1 232 ? 5.49389   1.56479   11.36282  0.550 22.29219 ? 1240 GLU A CB    1 
ATOM   1893 C CB    B GLU A 1 232 ? 5.93146   2.94254   11.70609  0.450 30.82427 ? 1240 GLU A CB    1 
ATOM   1894 C CG    A GLU A 1 232 ? 4.81854   1.42486   12.73312  0.550 23.47272 ? 1240 GLU A CG    1 
ATOM   1895 C CG    B GLU A 1 232 ? 6.68979   1.77511   12.29784  0.450 25.64380 ? 1240 GLU A CG    1 
ATOM   1896 C CD    A GLU A 1 232 ? 5.79358   1.36014   13.90677  0.550 24.65611 ? 1240 GLU A CD    1 
ATOM   1897 C CD    B GLU A 1 232 ? 7.42632   2.13829   13.57632  0.450 25.34311 ? 1240 GLU A CD    1 
ATOM   1898 O OE1   A GLU A 1 232 ? 6.98972   1.07181   13.69456  0.550 25.35291 ? 1240 GLU A OE1   1 
ATOM   1899 O OE1   B GLU A 1 232 ? 8.39355   2.92571   13.50766  0.450 26.81472 ? 1240 GLU A OE1   1 
ATOM   1900 O OE2   A GLU A 1 232 ? 5.35157   1.58378   15.05513  0.550 26.64130 ? 1240 GLU A OE2   1 
ATOM   1901 O OE2   B GLU A 1 232 ? 7.03170   1.63640   14.65063  0.450 25.86678 ? 1240 GLU A OE2   1 
ATOM   1902 N N     A GLN A 1 233 ? 5.30693   1.15635   7.86369   0.550 21.15568 ? 1241 GLN A N     1 
ATOM   1903 N N     B GLN A 1 233 ? 6.55877   2.41288   8.18491   0.450 20.40817 ? 1241 GLN A N     1 
ATOM   1904 C CA    A GLN A 1 233 ? 5.96627   1.55982   6.63002   0.550 23.58795 ? 1241 GLN A CA    1 
ATOM   1905 C CA    B GLN A 1 233 ? 7.37847   2.86886   7.07479   0.450 21.06838 ? 1241 GLN A CA    1 
ATOM   1906 C C     A GLN A 1 233 ? 5.21766   0.99429   5.42893   0.550 21.52758 ? 1241 GLN A C     1 
ATOM   1907 C C     B GLN A 1 233 ? 6.66158   2.57760   5.76632   0.450 22.62159 ? 1241 GLN A C     1 
ATOM   1908 O O     A GLN A 1 233 ? 4.58936   -0.06666  5.50258   0.550 20.39234 ? 1241 GLN A O     1 
ATOM   1909 O O     B GLN A 1 233 ? 5.80652   1.69192   5.68588   0.450 21.52064 ? 1241 GLN A O     1 
ATOM   1910 C CB    A GLN A 1 233 ? 7.42730   1.07865   6.58771   0.550 18.74577 ? 1241 GLN A CB    1 
ATOM   1911 C CB    B GLN A 1 233 ? 8.73867   2.16423   7.05605   0.450 23.20283 ? 1241 GLN A CB    1 
ATOM   1912 C CG    A GLN A 1 233 ? 8.30463   1.62862   7.70872   0.550 20.64253 ? 1241 GLN A CG    1 
ATOM   1913 C CG    B GLN A 1 233 ? 9.64461   2.51690   8.21988   0.450 19.32807 ? 1241 GLN A CG    1 
ATOM   1914 C CD    A GLN A 1 233 ? 9.64423   0.92161   7.80483   0.550 20.00353 ? 1241 GLN A CD    1 
ATOM   1915 C CD    B GLN A 1 233 ? 10.91541  1.69003   8.22285   0.450 23.58110 ? 1241 GLN A CD    1 
ATOM   1916 O OE1   A GLN A 1 233 ? 9.80228   -0.19412  7.31824   0.550 19.67557 ? 1241 GLN A OE1   1 
ATOM   1917 O OE1   B GLN A 1 233 ? 10.96236  0.60665   7.64108   0.450 22.27846 ? 1241 GLN A OE1   1 
ATOM   1918 N NE2   A GLN A 1 233 ? 10.61184  1.56732   8.44864   0.550 22.72383 ? 1241 GLN A NE2   1 
ATOM   1919 N NE2   B GLN A 1 233 ? 11.95471  2.19829   8.87239   0.450 25.37027 ? 1241 GLN A NE2   1 
ATOM   1920 N N     A LYS A 1 234 ? 5.29329   1.71631   4.31439   0.550 22.68580 ? 1242 LYS A N     1 
ATOM   1921 N N     B LYS A 1 234 ? 7.02316   3.33688   4.73542   0.450 25.95071 ? 1242 LYS A N     1 
ATOM   1922 C CA    A LYS A 1 234 ? 4.67972   1.30214   3.06270   0.550 25.86412 ? 1242 LYS A CA    1 
ATOM   1923 C CA    B LYS A 1 234 ? 6.54542   3.08286   3.38777   0.450 23.39177 ? 1242 LYS A CA    1 
ATOM   1924 C C     A LYS A 1 234 ? 5.74218   1.20585   1.97724   0.550 23.25824 ? 1242 LYS A C     1 
ATOM   1925 C C     B LYS A 1 234 ? 7.73292   2.98315   2.44316   0.450 22.40860 ? 1242 LYS A C     1 
ATOM   1926 O O     A LYS A 1 234 ? 6.68393   2.00522   1.94405   0.550 25.14811 ? 1242 LYS A O     1 
ATOM   1927 O O     B LYS A 1 234 ? 8.77699   3.60628   2.65702   0.450 24.05669 ? 1242 LYS A O     1 
ATOM   1928 C CB    A LYS A 1 234 ? 3.58416   2.28580   2.63309   0.550 25.56513 ? 1242 LYS A CB    1 
ATOM   1929 C CB    B LYS A 1 234 ? 5.56981   4.16808   2.89583   0.450 29.29940 ? 1242 LYS A CB    1 
ATOM   1930 C CG    A LYS A 1 234 ? 3.22035   3.32865   3.68128   0.550 29.18740 ? 1242 LYS A CG    1 
ATOM   1931 C CG    B LYS A 1 234 ? 6.14036   5.58118   2.86701   0.450 33.98891 ? 1242 LYS A CG    1 
ATOM   1932 C CD    A LYS A 1 234 ? 3.81208   4.68866   3.34620   0.550 31.51718 ? 1242 LYS A CD    1 
ATOM   1933 C CD    B LYS A 1 234 ? 6.02135   6.19846   1.47874   0.450 32.84098 ? 1242 LYS A CD    1 
ATOM   1934 C CE    A LYS A 1 234 ? 5.23440   4.82092   3.86010   0.550 33.55507 ? 1242 LYS A CE    1 
ATOM   1935 C CE    B LYS A 1 234 ? 7.31713   6.86869   1.04859   0.450 29.58926 ? 1242 LYS A CE    1 
ATOM   1936 N NZ    A LYS A 1 234 ? 6.22659   4.49852   2.79516   0.550 32.83749 ? 1242 LYS A NZ    1 
ATOM   1937 N NZ    B LYS A 1 234 ? 8.49121   6.30233   1.76454   0.450 34.19088 ? 1242 LYS A NZ    1 
ATOM   1938 N N     A ASN A 1 235 ? 5.59123   0.22109   1.09335   0.550 25.79761 ? 1243 ASN A N     1 
ATOM   1939 N N     B ASN A 1 235 ? 7.56363   2.18319   1.39888   0.450 22.97597 ? 1243 ASN A N     1 
ATOM   1940 C CA    A ASN A 1 235 ? 6.52313   0.06030   -0.01015  0.550 23.92506 ? 1243 ASN A CA    1 
ATOM   1941 C CA    B ASN A 1 235 ? 8.58947   2.03862   0.38479   0.450 24.55665 ? 1243 ASN A CA    1 
ATOM   1942 C C     A ASN A 1 235 ? 6.23469   1.08735   -1.10349  0.550 27.14692 ? 1243 ASN A C     1 
ATOM   1943 C C     B ASN A 1 235 ? 8.56727   3.23677   -0.56062  0.450 27.35200 ? 1243 ASN A C     1 
ATOM   1944 O O     A ASN A 1 235 ? 5.35061   1.94143   -0.98471  0.550 26.76159 ? 1243 ASN A O     1 
ATOM   1945 O O     B ASN A 1 235 ? 7.71202   4.12001   -0.46950  0.450 26.49452 ? 1243 ASN A O     1 
ATOM   1946 C CB    A ASN A 1 235 ? 6.52005   -1.37973  -0.52805  0.550 21.88013 ? 1243 ASN A CB    1 
ATOM   1947 C CB    B ASN A 1 235 ? 8.38841   0.72709   -0.36964  0.450 25.11591 ? 1243 ASN A CB    1 
ATOM   1948 C CG    A ASN A 1 235 ? 5.16045   -1.82465  -1.05280  0.550 27.94720 ? 1243 ASN A CG    1 
ATOM   1949 C CG    B ASN A 1 235 ? 9.62915   0.28448   -1.10676  0.450 24.87366 ? 1243 ASN A CG    1 
ATOM   1950 O OD1   A ASN A 1 235 ? 4.54236   -1.14920  -1.87973  0.550 25.91497 ? 1243 ASN A OD1   1 
ATOM   1951 O OD1   B ASN A 1 235 ? 10.75398  0.55470   -0.68099  0.450 31.51176 ? 1243 ASN A OD1   1 
ATOM   1952 N ND2   A ASN A 1 235 ? 4.68845   -2.97205  -0.56917  0.550 23.56391 ? 1243 ASN A ND2   1 
ATOM   1953 N ND2   B ASN A 1 235 ? 9.43375   -0.42308  -2.20563  0.450 27.72817 ? 1243 ASN A ND2   1 
ATOM   1954 N N     A ARG A 1 236 ? 6.99941   0.99494   -2.18657  0.550 22.31275 ? 1244 ARG A N     1 
ATOM   1955 N N     B ARG A 1 236 ? 9.53317   3.26163   -1.48213  0.450 24.67757 ? 1244 ARG A N     1 
ATOM   1956 C CA    A ARG A 1 236 ? 6.88035   1.94478   -3.28796  0.550 26.97567 ? 1244 ARG A CA    1 
ATOM   1957 C CA    B ARG A 1 236 ? 9.64388   4.38463   -2.40805  0.450 32.83967 ? 1244 ARG A CA    1 
ATOM   1958 C C     A ARG A 1 236 ? 5.60471   1.75251   -4.10319  0.550 31.05781 ? 1244 ARG A C     1 
ATOM   1959 C C     B ARG A 1 236 ? 8.40132   4.53144   -3.27937  0.450 33.30848 ? 1244 ARG A C     1 
ATOM   1960 O O     A ARG A 1 236 ? 5.18774   2.68605   -4.79794  0.550 34.67380 ? 1244 ARG A O     1 
ATOM   1961 O O     B ARG A 1 236 ? 8.07115   5.64509   -3.70112  0.450 36.30990 ? 1244 ARG A O     1 
ATOM   1962 C CB    A ARG A 1 236 ? 8.10852   1.84505   -4.19329  0.550 28.38114 ? 1244 ARG A CB    1 
ATOM   1963 C CB    B ARG A 1 236 ? 10.89740  4.23357   -3.26941  0.450 33.16796 ? 1244 ARG A CB    1 
ATOM   1964 C CG    A ARG A 1 236 ? 8.28988   0.46064   -4.75658  0.550 29.71022 ? 1244 ARG A CG    1 
ATOM   1965 C CG    B ARG A 1 236 ? 12.19160  4.57645   -2.54482  0.450 36.64173 ? 1244 ARG A CG    1 
ATOM   1966 C CD    A ARG A 1 236 ? 9.37456   0.37534   -5.81562  0.550 32.52146 ? 1244 ARG A CD    1 
ATOM   1967 C CD    B ARG A 1 236 ? 12.98636  3.32221   -2.21945  0.450 36.29020 ? 1244 ARG A CD    1 
ATOM   1968 N NE    A ARG A 1 236 ? 9.17292   -0.69553  -6.79239  0.550 34.59971 ? 1244 ARG A NE    1 
ATOM   1969 N NE    B ARG A 1 236 ? 14.41164  3.59505   -2.07221  0.450 39.05803 ? 1244 ARG A NE    1 
ATOM   1970 C CZ    A ARG A 1 236 ? 8.01070   -1.16346  -7.24166  0.550 37.64009 ? 1244 ARG A CZ    1 
ATOM   1971 C CZ    B ARG A 1 236 ? 15.35924  3.06158   -2.83195  0.450 40.24918 ? 1244 ARG A CZ    1 
ATOM   1972 N NH1   A ARG A 1 236 ? 6.86792   -0.52099  -7.04959  0.550 40.21124 ? 1244 ARG A NH1   1 
ATOM   1973 N NH1   B ARG A 1 236 ? 15.06876  2.22101   -3.81226  0.450 38.02216 ? 1244 ARG A NH1   1 
ATOM   1974 N NH2   A ARG A 1 236 ? 7.99885   -2.28705  -7.94792  0.550 36.60174 ? 1244 ARG A NH2   1 
ATOM   1975 N NH2   B ARG A 1 236 ? 16.63058  3.37676   -2.60081  0.450 40.61038 ? 1244 ARG A NH2   1 
ATOM   1976 N N     A SER A 1 237 ? 4.98360   0.57248   -4.04745  0.550 27.36837 ? 1245 SER A N     1 
ATOM   1977 N N     B SER A 1 237 ? 7.70004   3.42876   -3.56044  0.450 30.81704 ? 1245 SER A N     1 
ATOM   1978 C CA    A SER A 1 237 ? 3.71307   0.33467   -4.72511  0.550 31.81129 ? 1245 SER A CA    1 
ATOM   1979 C CA    B SER A 1 237 ? 6.45395   3.51469   -4.31544  0.450 31.05312 ? 1245 SER A CA    1 
ATOM   1980 C C     A SER A 1 237 ? 2.50173   0.61548   -3.84497  0.550 30.07356 ? 1245 SER A C     1 
ATOM   1981 C C     B SER A 1 237 ? 5.30567   4.06175   -3.47684  0.450 30.66612 ? 1245 SER A C     1 
ATOM   1982 O O     A SER A 1 237 ? 1.36816   0.54999   -4.33485  0.550 24.90206 ? 1245 SER A O     1 
ATOM   1983 O O     B SER A 1 237 ? 4.31799   4.54555   -4.04037  0.450 31.44155 ? 1245 SER A O     1 
ATOM   1984 C CB    A SER A 1 237 ? 3.63901   -1.10447  -5.24690  0.550 32.13619 ? 1245 SER A CB    1 
ATOM   1985 C CB    B SER A 1 237 ? 6.06932   2.14205   -4.87329  0.450 32.41139 ? 1245 SER A CB    1 
ATOM   1986 O OG    A SER A 1 237 ? 4.74179   -1.39831  -6.08242  0.550 36.89310 ? 1245 SER A OG    1 
ATOM   1987 O OG    B SER A 1 237 ? 7.03000   1.66923   -5.79954  0.450 31.36845 ? 1245 SER A OG    1 
ATOM   1988 N N     A GLY A 1 238 ? 2.70781   0.91447   -2.56587  0.550 28.44921 ? 1246 GLY A N     1 
ATOM   1989 N N     B GLY A 1 238 ? 5.40832   3.99061   -2.14992  0.450 32.04092 ? 1246 GLY A N     1 
ATOM   1990 C CA    A GLY A 1 238 ? 1.62676   1.24158   -1.65924  0.550 29.39219 ? 1246 GLY A CA    1 
ATOM   1991 C CA    B GLY A 1 238 ? 4.35632   4.44152   -1.25875  0.450 25.01727 ? 1246 GLY A CA    1 
ATOM   1992 C C     A GLY A 1 238 ? 1.25752   0.14893   -0.68295  0.550 27.72144 ? 1246 GLY A C     1 
ATOM   1993 C C     B GLY A 1 238 ? 3.55372   3.33796   -0.60657  0.450 29.41096 ? 1246 GLY A C     1 
ATOM   1994 O O     A GLY A 1 238 ? 0.47131   0.40902   0.23565   0.550 30.16289 ? 1246 GLY A O     1 
ATOM   1995 O O     B GLY A 1 238 ? 2.63593   3.64200   0.16450   0.450 30.28166 ? 1246 GLY A O     1 
ATOM   1996 N N     A GLY A 1 239 ? 1.78094   -1.06165  -0.84758  0.550 27.28642 ? 1247 GLY A N     1 
ATOM   1997 N N     B GLY A 1 239 ? 3.85297   2.06428   -0.89652  0.450 28.68584 ? 1247 GLY A N     1 
ATOM   1998 C CA    A GLY A 1 239 ? 1.50234   -2.11977  0.09943   0.550 22.23469 ? 1247 GLY A CA    1 
ATOM   1999 C CA    B GLY A 1 239 ? 3.20971   0.96418   -0.20961  0.450 28.35434 ? 1247 GLY A CA    1 
ATOM   2000 C C     A GLY A 1 239 ? 2.23276   -1.91310  1.41246   0.550 26.73746 ? 1247 GLY A C     1 
ATOM   2001 C C     B GLY A 1 239 ? 3.91277   0.61422   1.09008   0.450 28.61861 ? 1247 GLY A C     1 
ATOM   2002 O O     A GLY A 1 239 ? 3.11987   -1.06859  1.55258   0.550 25.29043 ? 1247 GLY A O     1 
ATOM   2003 O O     B GLY A 1 239 ? 4.97716   1.14622   1.40147   0.450 25.58886 ? 1247 GLY A O     1 
ATOM   2004 N N     A LYS A 1 240 ? 1.83224   -2.70145  2.40534   0.550 21.52406 ? 1248 LYS A N     1 
ATOM   2005 N N     B LYS A 1 240 ? 3.29065   -0.28579  1.85295   0.450 20.35565 ? 1248 LYS A N     1 
ATOM   2006 C CA    A LYS A 1 240 ? 2.58260   -2.75201  3.65165   0.550 23.06379 ? 1248 LYS A CA    1 
ATOM   2007 C CA    B LYS A 1 240 ? 3.88566   -0.73148  3.10495   0.450 24.26724 ? 1248 LYS A CA    1 
ATOM   2008 C C     A LYS A 1 240 ? 4.01481   -3.18770  3.35955   0.550 20.70584 ? 1248 LYS A C     1 
ATOM   2009 C C     B LYS A 1 240 ? 5.25118   -1.35742  2.84440   0.450 23.45924 ? 1248 LYS A C     1 
ATOM   2010 O O     A LYS A 1 240 ? 4.27190   -3.99257  2.45974   0.550 21.05365 ? 1248 LYS A O     1 
ATOM   2011 O O     B LYS A 1 240 ? 5.51412   -1.91480  1.77468   0.450 25.04183 ? 1248 LYS A O     1 
ATOM   2012 C CB    A LYS A 1 240 ? 1.92467   -3.73659  4.62165   0.550 24.01312 ? 1248 LYS A CB    1 
ATOM   2013 C CB    B LYS A 1 240 ? 2.97232   -1.73603  3.81583   0.450 22.35767 ? 1248 LYS A CB    1 
ATOM   2014 C CG    A LYS A 1 240 ? 0.55158   -3.29602  5.12847   0.550 28.32600 ? 1248 LYS A CG    1 
ATOM   2015 C CG    B LYS A 1 240 ? 1.77549   -1.11047  4.52646   0.450 26.78040 ? 1248 LYS A CG    1 
ATOM   2016 C CD    A LYS A 1 240 ? 0.30390   -3.68292  6.59158   0.550 29.76261 ? 1248 LYS A CD    1 
ATOM   2017 C CD    B LYS A 1 240 ? 1.13780   -2.08957  5.50849   0.450 25.88696 ? 1248 LYS A CD    1 
ATOM   2018 C CE    A LYS A 1 240 ? 0.74641   -5.11278  6.88009   0.550 25.67870 ? 1248 LYS A CE    1 
ATOM   2019 C CE    B LYS A 1 240 ? 0.26012   -3.10972  4.80070   0.450 29.75572 ? 1248 LYS A CE    1 
ATOM   2020 N NZ    A LYS A 1 240 ? -0.32617  -5.95602  7.48792   0.550 28.96813 ? 1248 LYS A NZ    1 
ATOM   2021 N NZ    B LYS A 1 240 ? -0.40815  -4.04399  5.75992   0.450 29.89866 ? 1248 LYS A NZ    1 
ATOM   2022 N N     A MET A 1 241 ? 4.95581   -2.64012  4.12439   0.550 20.23057 ? 1249 MET A N     1 
ATOM   2023 N N     B MET A 1 241 ? 6.12989   -1.24454  3.83419   0.450 21.92393 ? 1249 MET A N     1 
ATOM   2024 C CA    A MET A 1 241 ? 6.37430   -2.88379  3.88178   0.550 20.20714 ? 1249 MET A CA    1 
ATOM   2025 C CA    B MET A 1 241 ? 7.51102   -1.70538  3.72448   0.450 18.91870 ? 1249 MET A CA    1 
ATOM   2026 C C     A MET A 1 241 ? 6.77628   -4.23074  4.46695   0.550 16.39991 ? 1249 MET A C     1 
ATOM   2027 C C     B MET A 1 241 ? 7.59364   -3.09928  4.33133   0.450 19.79467 ? 1249 MET A C     1 
ATOM   2028 O O     A MET A 1 241 ? 6.81325   -4.39802  5.69003   0.550 18.46780 ? 1249 MET A O     1 
ATOM   2029 O O     B MET A 1 241 ? 7.60201   -3.25505  5.55469   0.450 18.02223 ? 1249 MET A O     1 
ATOM   2030 C CB    A MET A 1 241 ? 7.22582   -1.78124  4.49612   0.550 20.09840 ? 1249 MET A CB    1 
ATOM   2031 C CB    B MET A 1 241 ? 8.45174   -0.74461  4.44354   0.450 22.26562 ? 1249 MET A CB    1 
ATOM   2032 C CG    A MET A 1 241 ? 8.69432   -1.91003  4.14335   0.550 18.93928 ? 1249 MET A CG    1 
ATOM   2033 C CG    B MET A 1 241 ? 9.92758   -1.11221  4.33319   0.450 24.21960 ? 1249 MET A CG    1 
ATOM   2034 S SD    A MET A 1 241 ? 9.07948   -1.25179  2.50790   0.550 20.39801 ? 1249 MET A SD    1 
ATOM   2035 S SD    B MET A 1 241 ? 10.63122  -0.76703  2.70745   0.450 25.35014 ? 1249 MET A SD    1 
ATOM   2036 C CE    A MET A 1 241 ? 9.50943   0.43364   2.93305   0.550 24.16426 ? 1249 MET A CE    1 
ATOM   2037 C CE    B MET A 1 241 ? 11.03953  0.95976   2.93178   0.450 28.67685 ? 1249 MET A CE    1 
ATOM   2038 N N     A TYR A 1 242 ? 7.11589   -5.17258  3.59689   0.550 16.59181 ? 1250 TYR A N     1 
ATOM   2039 N N     B TYR A 1 242 ? 7.64622   -4.11149  3.47238   0.450 18.84274 ? 1250 TYR A N     1 
ATOM   2040 C CA    A TYR A 1 242 ? 7.57683   -6.49331  3.99299   0.550 14.99963 ? 1250 TYR A CA    1 
ATOM   2041 C CA    B TYR A 1 242 ? 7.94215   -5.47513  3.88174   0.450 17.74190 ? 1250 TYR A CA    1 
ATOM   2042 C C     A TYR A 1 242 ? 9.05509   -6.64044  3.65233   0.550 17.43098 ? 1250 TYR A C     1 
ATOM   2043 C C     B TYR A 1 242 ? 9.40998   -5.77383  3.59791   0.450 16.23037 ? 1250 TYR A C     1 
ATOM   2044 O O     A TYR A 1 242 ? 9.64627   -5.80146  2.97055   0.550 13.38367 ? 1250 TYR A O     1 
ATOM   2045 O O     B TYR A 1 242 ? 10.10286  -5.00991  2.92170   0.450 16.88803 ? 1250 TYR A O     1 
ATOM   2046 C CB    A TYR A 1 242 ? 6.74483   -7.56898  3.29190   0.550 18.95608 ? 1250 TYR A CB    1 
ATOM   2047 C CB    B TYR A 1 242 ? 7.02276   -6.46965  3.16295   0.450 15.74550 ? 1250 TYR A CB    1 
ATOM   2048 C CG    A TYR A 1 242 ? 5.28914   -7.57426  3.71172   0.550 21.28513 ? 1250 TYR A CG    1 
ATOM   2049 C CG    B TYR A 1 242 ? 5.56450   -6.35631  3.56146   0.450 18.07802 ? 1250 TYR A CG    1 
ATOM   2050 C CD1   A TYR A 1 242 ? 4.93372   -7.71604  5.04448   0.550 22.38266 ? 1250 TYR A CD1   1 
ATOM   2051 C CD1   B TYR A 1 242 ? 5.14287   -6.67773  4.84361   0.450 21.51456 ? 1250 TYR A CD1   1 
ATOM   2052 C CD2   A TYR A 1 242 ? 4.27052   -7.44697  2.77061   0.550 21.99742 ? 1250 TYR A CD2   1 
ATOM   2053 C CD2   B TYR A 1 242 ? 4.61137   -5.92004  2.65138   0.450 21.61267 ? 1250 TYR A CD2   1 
ATOM   2054 C CE1   A TYR A 1 242 ? 3.60278   -7.72341  5.43754   0.550 22.59200 ? 1250 TYR A CE1   1 
ATOM   2055 C CE1   B TYR A 1 242 ? 3.80857   -6.57111  5.20857   0.450 24.79272 ? 1250 TYR A CE1   1 
ATOM   2056 C CE2   A TYR A 1 242 ? 2.93507   -7.45357  3.15264   0.550 21.96255 ? 1250 TYR A CE2   1 
ATOM   2057 C CE2   B TYR A 1 242 ? 3.27905   -5.81037  3.00816   0.450 21.51890 ? 1250 TYR A CE2   1 
ATOM   2058 C CZ    A TYR A 1 242 ? 2.61006   -7.59648  4.48744   0.550 26.32008 ? 1250 TYR A CZ    1 
ATOM   2059 C CZ    B TYR A 1 242 ? 2.88372   -6.13506  4.28215   0.450 24.74747 ? 1250 TYR A CZ    1 
ATOM   2060 O OH    A TYR A 1 242 ? 1.29250   -7.60833  4.88399   0.550 28.18082 ? 1250 TYR A OH    1 
ATOM   2061 O OH    B TYR A 1 242 ? 1.55553   -6.02613  4.62727   0.450 28.99270 ? 1250 TYR A OH    1 
ATOM   2062 N N     A VAL A 1 243 ? 9.65846   -7.73085  4.13220   0.550 14.29114 ? 1251 VAL A N     1 
ATOM   2063 N N     B VAL A 1 243 ? 9.89619   -6.88708  4.15607   0.450 15.07558 ? 1251 VAL A N     1 
ATOM   2064 C CA    A VAL A 1 243 ? 11.09845  -7.90339  3.95344   0.550 15.22132 ? 1251 VAL A CA    1 
ATOM   2065 C CA    B VAL A 1 243 ? 11.30939  -7.21736  3.98332   0.450 13.46416 ? 1251 VAL A CA    1 
ATOM   2066 C C     A VAL A 1 243 ? 11.49239  -7.97920  2.47792   0.550 15.93259 ? 1251 VAL A C     1 
ATOM   2067 C C     B VAL A 1 243 ? 11.67198  -7.35063  2.50769   0.450 12.77045 ? 1251 VAL A C     1 
ATOM   2068 O O     A VAL A 1 243 ? 12.59176  -7.55262  2.09918   0.550 15.23091 ? 1251 VAL A O     1 
ATOM   2069 O O     B VAL A 1 243 ? 12.78260  -6.98709  2.10077   0.450 13.34419 ? 1251 VAL A O     1 
ATOM   2070 C CB    A VAL A 1 243 ? 11.60385  -9.10211  4.78267   0.550 15.50602 ? 1251 VAL A CB    1 
ATOM   2071 C CB    B VAL A 1 243 ? 11.72323  -8.44039  4.83098   0.450 15.09864 ? 1251 VAL A CB    1 
ATOM   2072 C CG1   A VAL A 1 243 ? 11.12055  -10.41529 4.18110   0.550 15.21647 ? 1251 VAL A CG1   1 
ATOM   2073 C CG1   B VAL A 1 243 ? 11.24500  -9.73740  4.19008   0.450 15.36211 ? 1251 VAL A CG1   1 
ATOM   2074 C CG2   A VAL A 1 243 ? 13.12423  -9.06053  4.91911   0.550 16.20567 ? 1251 VAL A CG2   1 
ATOM   2075 C CG2   B VAL A 1 243 ? 13.23722  -8.45517  5.04151   0.450 11.96638 ? 1251 VAL A CG2   1 
ATOM   2076 N N     A GLN A 1 244 ? 10.61391  -8.49914  1.61562   0.550 15.11349 ? 1252 GLN A N     1 
ATOM   2077 N N     B GLN A 1 244 ? 10.74470  -7.83899  1.67399   0.450 14.82486 ? 1252 GLN A N     1 
ATOM   2078 C CA    A GLN A 1 244 ? 10.96436  -8.57004  0.19737   0.550 16.21271 ? 1252 GLN A CA    1 
ATOM   2079 C CA    B GLN A 1 244 ? 11.04536  -7.93250  0.24834   0.450 17.60577 ? 1252 GLN A CA    1 
ATOM   2080 C C     A GLN A 1 244 ? 11.07572  -7.18363  -0.42980  0.550 15.94822 ? 1252 GLN A C     1 
ATOM   2081 C C     B GLN A 1 244 ? 11.20659  -6.55322  -0.37713  0.450 14.84927 ? 1252 GLN A C     1 
ATOM   2082 O O     A GLN A 1 244 ? 11.81789  -7.00181  -1.40296  0.550 16.83208 ? 1252 GLN A O     1 
ATOM   2083 O O     B GLN A 1 244 ? 11.99892  -6.38919  -1.31159  0.450 14.81689 ? 1252 GLN A O     1 
ATOM   2084 C CB    A GLN A 1 244 ? 9.96184   -9.43314  -0.56785  0.550 17.38669 ? 1252 GLN A CB    1 
ATOM   2085 C CB    B GLN A 1 244 ? 9.98216   -8.74701  -0.49183  0.450 16.86030 ? 1252 GLN A CB    1 
ATOM   2086 C CG    A GLN A 1 244 ? 8.52542   -8.95305  -0.48410  0.550 16.68155 ? 1252 GLN A CG    1 
ATOM   2087 C CG    B GLN A 1 244 ? 8.56608   -8.19576  -0.39394  0.450 17.27492 ? 1252 GLN A CG    1 
ATOM   2088 C CD    A GLN A 1 244 ? 7.75779   -9.62435  0.63269   0.550 17.54097 ? 1252 GLN A CD    1 
ATOM   2089 C CD    B GLN A 1 244 ? 7.76782   -8.82465  0.73264   0.450 16.01269 ? 1252 GLN A CD    1 
ATOM   2090 O OE1   A GLN A 1 244 ? 8.33162   -10.00267 1.66186   0.550 16.11680 ? 1252 GLN A OE1   1 
ATOM   2091 O OE1   B GLN A 1 244 ? 8.32475   -9.23039  1.75808   0.450 15.79743 ? 1252 GLN A OE1   1 
ATOM   2092 N NE2   A GLN A 1 244 ? 6.45021   -9.76643  0.44826   0.550 17.51877 ? 1252 GLN A NE2   1 
ATOM   2093 N NE2   B GLN A 1 244 ? 6.45413   -8.92768  0.54180   0.450 18.76323 ? 1252 GLN A NE2   1 
ATOM   2094 N N     A ASP A 1 245 ? 10.36850  -6.19350  0.12255   0.550 14.28145 ? 1253 ASP A N     1 
ATOM   2095 N N     B ASP A 1 245 ? 10.48357  -5.55205  0.13363   0.450 17.19194 ? 1253 ASP A N     1 
ATOM   2096 C CA    A ASP A 1 245 ? 10.46147  -4.83651  -0.40444  0.550 19.07939 ? 1253 ASP A CA    1 
ATOM   2097 C CA    B ASP A 1 245 ? 10.68645  -4.18985  -0.34762  0.450 18.43679 ? 1253 ASP A CA    1 
ATOM   2098 C C     A ASP A 1 245 ? 11.79754  -4.18459  -0.05545  0.550 19.88881 ? 1253 ASP A C     1 
ATOM   2099 C C     B ASP A 1 245 ? 12.08099  -3.68758  -0.00584  0.450 19.41143 ? 1253 ASP A C     1 
ATOM   2100 O O     A ASP A 1 245 ? 12.30406  -3.36160  -0.82399  0.550 16.96674 ? 1253 ASP A O     1 
ATOM   2101 O O     B ASP A 1 245 ? 12.65052  -2.88690  -0.75349  0.450 17.69955 ? 1253 ASP A O     1 
ATOM   2102 C CB    A ASP A 1 245 ? 9.28675   -4.00611  0.11036   0.550 18.69235 ? 1253 ASP A CB    1 
ATOM   2103 C CB    B ASP A 1 245 ? 9.61400   -3.25727  0.21511   0.450 17.45680 ? 1253 ASP A CB    1 
ATOM   2104 C CG    A ASP A 1 245 ? 7.94235   -4.60088  -0.27835  0.550 18.36896 ? 1253 ASP A CG    1 
ATOM   2105 C CG    B ASP A 1 245 ? 8.21951   -3.64353  -0.23238  0.450 21.65708 ? 1253 ASP A CG    1 
ATOM   2106 O OD1   A ASP A 1 245 ? 7.75697   -4.92804  -1.46873  0.550 21.95005 ? 1253 ASP A OD1   1 
ATOM   2107 O OD1   B ASP A 1 245 ? 7.97799   -3.67994  -1.45908  0.450 20.95331 ? 1253 ASP A OD1   1 
ATOM   2108 O OD2   A ASP A 1 245 ? 7.08491   -4.75872  0.60967   0.550 18.22143 ? 1253 ASP A OD2   1 
ATOM   2109 O OD2   B ASP A 1 245 ? 7.37068   -3.93039  0.63829   0.450 21.58677 ? 1253 ASP A OD2   1 
ATOM   2110 N N     A LYS A 1 246 ? 12.38176  -4.53798  1.09312   0.550 18.76985 ? 1254 LYS A N     1 
ATOM   2111 N N     B LYS A 1 246 ? 12.64976  -4.15060  1.11409   0.450 19.16349 ? 1254 LYS A N     1 
ATOM   2112 C CA    A LYS A 1 246 ? 13.71188  -4.04191  1.43941   0.550 17.42910 ? 1254 LYS A CA    1 
ATOM   2113 C CA    B LYS A 1 246 ? 14.04798  -3.84945  1.40047   0.450 18.04594 ? 1254 LYS A CA    1 
ATOM   2114 C C     A LYS A 1 246 ? 14.77734  -4.61327  0.50774   0.550 17.02307 ? 1254 LYS A C     1 
ATOM   2115 C C     B LYS A 1 246 ? 14.99366  -4.64089  0.51259   0.450 16.97667 ? 1254 LYS A C     1 
ATOM   2116 O O     A LYS A 1 246 ? 15.67626  -3.88908  0.06087   0.550 18.43173 ? 1254 LYS A O     1 
ATOM   2117 O O     B LYS A 1 246 ? 16.01586  -4.09903  0.06782   0.450 18.38433 ? 1254 LYS A O     1 
ATOM   2118 C CB    A LYS A 1 246 ? 14.02498  -4.42192  2.88943   0.550 18.12742 ? 1254 LYS A CB    1 
ATOM   2119 C CB    B LYS A 1 246 ? 14.38204  -4.05281  2.87697   0.450 19.83591 ? 1254 LYS A CB    1 
ATOM   2120 C CG    A LYS A 1 246 ? 15.15448  -3.63680  3.56108   0.550 20.48164 ? 1254 LYS A CG    1 
ATOM   2121 C CG    B LYS A 1 246 ? 13.52031  -3.26957  3.82351   0.450 18.77677 ? 1254 LYS A CG    1 
ATOM   2122 C CD    A LYS A 1 246 ? 15.16823  -2.15298  3.23671   0.550 24.26944 ? 1254 LYS A CD    1 
ATOM   2123 C CD    B LYS A 1 246 ? 13.67852  -1.77376  3.59335   0.450 22.39715 ? 1254 LYS A CD    1 
ATOM   2124 C CE    A LYS A 1 246 ? 14.22213  -1.40591  4.15262   0.550 23.20129 ? 1254 LYS A CE    1 
ATOM   2125 C CE    B LYS A 1 246 ? 15.05096  -1.24562  3.96336   0.450 22.95417 ? 1254 LYS A CE    1 
ATOM   2126 N NZ    A LYS A 1 246 ? 14.28922  0.06856   3.97805   0.550 20.59435 ? 1254 LYS A NZ    1 
ATOM   2127 N NZ    B LYS A 1 246 ? 15.12998  0.25003   3.83059   0.450 21.08609 ? 1254 LYS A NZ    1 
ATOM   2128 N N     . ILE A 1 247 ? 14.69875  -5.91989  0.24223   1.000 17.82295 ? 1255 ILE A N     1 
ATOM   2129 C CA    . ILE A 1 247 ? 15.53048  -6.60267  -0.75014  1.000 17.40705 ? 1255 ILE A CA    1 
ATOM   2130 C C     . ILE A 1 247 ? 15.50568  -5.83234  -2.06638  1.000 18.95387 ? 1255 ILE A C     1 
ATOM   2131 O O     . ILE A 1 247 ? 16.55150  -5.54924  -2.66105  1.000 18.45932 ? 1255 ILE A O     1 
ATOM   2132 N N     . GLU A 1 248 ? 14.30902  -5.41225  -2.48725  1.000 17.37467 ? 1256 GLU A N     1 
ATOM   2133 C CA    . GLU A 1 248 ? 14.16829  -4.71770  -3.76351  1.000 17.03863 ? 1256 GLU A CA    1 
ATOM   2134 C C     . GLU A 1 248 ? 14.91911  -3.39514  -3.78364  1.000 18.88316 ? 1256 GLU A C     1 
ATOM   2135 O O     . GLU A 1 248 ? 15.44333  -3.00312  -4.83387  1.000 18.59406 ? 1256 GLU A O     1 
ATOM   2136 C CB    . GLU A 1 248 ? 12.69019  -4.50372  -4.08076  1.000 19.66119 ? 1256 GLU A CB    1 
ATOM   2137 C CG    . GLU A 1 248 ? 12.45122  -3.95374  -5.48092  1.000 18.60011 ? 1256 GLU A CG    1 
ATOM   2138 C CD    . GLU A 1 248 ? 11.00420  -3.57866  -5.72120  1.000 31.60371 ? 1256 GLU A CD    1 
ATOM   2139 O OE1   . GLU A 1 248 ? 10.11115  -4.21875  -5.12950  1.000 34.37205 ? 1256 GLU A OE1   1 
ATOM   2140 O OE2   . GLU A 1 248 ? 10.75646  -2.65484  -6.52528  1.000 41.34553 ? 1256 GLU A OE2   1 
ATOM   2141 N N     . GLU A 1 249 ? 14.98613  -2.68930  -2.64806  1.000 17.67621 ? 1257 GLU A N     1 
ATOM   2142 C CA    . GLU A 1 249 ? 15.76180  -1.45330  -2.58962  1.000 17.83435 ? 1257 GLU A CA    1 
ATOM   2143 C C     . GLU A 1 249 ? 17.22602  -1.68547  -2.91293  1.000 20.12130 ? 1257 GLU A C     1 
ATOM   2144 O O     . GLU A 1 249 ? 17.92221  -0.75308  -3.33027  1.000 22.44074 ? 1257 GLU A O     1 
ATOM   2145 C CB    . GLU A 1 249 ? 15.68226  -0.83153  -1.19303  1.000 21.62503 ? 1257 GLU A CB    1 
ATOM   2146 C CG    . GLU A 1 249 ? 14.35829  -0.18894  -0.86806  1.000 26.18721 ? 1257 GLU A CG    1 
ATOM   2147 C CD    . GLU A 1 249 ? 14.37237  0.53619   0.46671   1.000 32.69614 ? 1257 GLU A CD    1 
ATOM   2148 O OE1   . GLU A 1 249 ? 15.43529  0.59111   1.12241   1.000 29.68577 ? 1257 GLU A OE1   1 
ATOM   2149 O OE2   . GLU A 1 249 ? 13.31369  1.07350   0.84437   1.000 36.10923 ? 1257 GLU A OE2   1 
ATOM   2150 N N     . TYR A 1 250 ? 17.71829  -2.89954  -2.69959  1.000 16.01097 ? 1258 TYR A N     1 
ATOM   2151 C CA    . TYR A 1 250 ? 19.08661  -3.26712  -3.01014  1.000 15.58522 ? 1258 TYR A CA    1 
ATOM   2152 C C     . TYR A 1 250 ? 19.12260  -4.34834  -4.08078  1.000 15.15179 ? 1258 TYR A C     1 
ATOM   2153 O O     . TYR A 1 250 ? 19.92484  -5.28029  -4.00997  1.000 15.49402 ? 1258 TYR A O     1 
ATOM   2154 C CB    . TYR A 1 250 ? 19.79761  -3.75563  -1.75282  1.000 15.03627 ? 1258 TYR A CB    1 
ATOM   2155 C CG    . TYR A 1 250 ? 19.83012  -2.75447  -0.62112  1.000 16.27046 ? 1258 TYR A CG    1 
ATOM   2156 C CD1   . TYR A 1 250 ? 20.82821  -1.78186  -0.55185  1.000 16.94067 ? 1258 TYR A CD1   1 
ATOM   2157 C CD2   . TYR A 1 250 ? 18.86001  -2.77821  0.37798   1.000 14.16272 ? 1258 TYR A CD2   1 
ATOM   2158 C CE1   . TYR A 1 250 ? 20.86723  -0.85944  0.51450   1.000 16.49653 ? 1258 TYR A CE1   1 
ATOM   2159 C CE2   . TYR A 1 250 ? 18.89713  -1.86912  1.43912   1.000 15.96388 ? 1258 TYR A CE2   1 
ATOM   2160 C CZ    . TYR A 1 250 ? 19.89911  -0.92182  1.49577   1.000 17.29486 ? 1258 TYR A CZ    1 
ATOM   2161 O OH    . TYR A 1 250 ? 19.93426  -0.02928  2.54775   1.000 19.26965 ? 1258 TYR A OH    1 
ATOM   2162 N N     A SER A 1 251 ? 18.25249  -4.20608  -5.09256  0.533 15.74355 ? 1259 SER A N     1 
ATOM   2163 N N     B SER A 1 251 ? 18.27690  -4.21665  -5.10633  0.467 15.74235 ? 1259 SER A N     1 
ATOM   2164 C CA    A SER A 1 251 ? 18.10977  -5.20500  -6.15266  0.533 15.35709 ? 1259 SER A CA    1 
ATOM   2165 C CA    B SER A 1 251 ? 18.13969  -5.27950  -6.10005  0.467 15.36928 ? 1259 SER A CA    1 
ATOM   2166 C C     A SER A 1 251 ? 19.45102  -5.53286  -6.79681  0.533 15.22151 ? 1259 SER A C     1 
ATOM   2167 C C     B SER A 1 251 ? 19.45377  -5.55229  -6.82836  0.467 15.26088 ? 1259 SER A C     1 
ATOM   2168 O O     A SER A 1 251 ? 19.82685  -6.70300  -6.93785  0.533 16.95075 ? 1259 SER A O     1 
ATOM   2169 O O     B SER A 1 251 ? 19.81865  -6.71411  -7.05121  0.467 16.76892 ? 1259 SER A O     1 
ATOM   2170 C CB    A SER A 1 251 ? 17.16233  -4.66714  -7.23521  0.533 16.87823 ? 1259 SER A CB    1 
ATOM   2171 C CB    B SER A 1 251 ? 17.04531  -4.90787  -7.09897  0.467 17.64899 ? 1259 SER A CB    1 
ATOM   2172 O OG    A SER A 1 251 ? 15.80593  -4.67601  -6.83271  0.533 15.55889 ? 1259 SER A OG    1 
ATOM   2173 O OG    B SER A 1 251 ? 17.40826  -3.73669  -7.80090  0.467 17.74088 ? 1259 SER A OG    1 
ATOM   2174 N N     . ASP A 1 252 ? 20.17610  -4.49654  -7.22550  1.000 16.80460 ? 1260 ASP A N     1 
ATOM   2175 C CA    A ASP A 1 252 ? 21.40430  -4.70288  -7.98466  0.637 16.55212 ? 1260 ASP A CA    1 
ATOM   2176 C CA    B ASP A 1 252 ? 21.40261  -4.70873  -7.98337  0.363 16.64465 ? 1260 ASP A CA    1 
ATOM   2177 C C     . ASP A 1 252 ? 22.51361  -5.26754  -7.09934  1.000 13.98399 ? 1260 ASP A C     1 
ATOM   2178 O O     . ASP A 1 252 ? 23.21979  -6.19953  -7.49243  1.000 14.63812 ? 1260 ASP A O     1 
ATOM   2179 C CB    A ASP A 1 252 ? 21.80762  -3.37335  -8.63805  0.637 16.93036 ? 1260 ASP A CB    1 
ATOM   2180 C CB    B ASP A 1 252 ? 21.82757  -3.41047  -8.67038  0.363 17.01634 ? 1260 ASP A CB    1 
ATOM   2181 C CG    A ASP A 1 252 ? 22.80441  -3.53092  -9.77993  0.637 20.69103 ? 1260 ASP A CG    1 
ATOM   2182 C CG    B ASP A 1 252 ? 22.92071  -3.62547  -9.69230  0.363 20.67012 ? 1260 ASP A CG    1 
ATOM   2183 O OD1   A ASP A 1 252 ? 23.00380  -4.65274  -10.30033 0.637 19.26259 ? 1260 ASP A OD1   1 
ATOM   2184 O OD1   B ASP A 1 252 ? 22.63437  -4.21349  -10.75899 0.363 20.91292 ? 1260 ASP A OD1   1 
ATOM   2185 O OD2   A ASP A 1 252 ? 23.38930  -2.49436  -10.17383 0.637 22.40643 ? 1260 ASP A OD2   1 
ATOM   2186 O OD2   B ASP A 1 252 ? 24.06808  -3.20517  -9.42859  0.363 23.69566 ? 1260 ASP A OD2   1 
ATOM   2187 N N     . GLU A 1 253 ? 22.68245  -4.71771  -5.89635  1.000 15.50733 ? 1261 GLU A N     1 
ATOM   2188 C CA    . GLU A 1 253 ? 23.74231  -5.21397  -5.02364  1.000 16.44110 ? 1261 GLU A CA    1 
ATOM   2189 C C     . GLU A 1 253 ? 23.52244  -6.68891  -4.67602  1.000 13.32952 ? 1261 GLU A C     1 
ATOM   2190 O O     . GLU A 1 253 ? 24.45755  -7.49918  -4.72853  1.000 15.21476 ? 1261 GLU A O     1 
ATOM   2191 C CB    . GLU A 1 253 ? 23.81056  -4.34883  -3.76162  1.000 16.31985 ? 1261 GLU A CB    1 
ATOM   2192 C CG    . GLU A 1 253 ? 24.39577  -2.94172  -4.00255  1.000 18.41297 ? 1261 GLU A CG    1 
ATOM   2193 C CD    . GLU A 1 253 ? 24.77327  -2.23201  -2.70722  1.000 20.49929 ? 1261 GLU A CD    1 
ATOM   2194 O OE1   . GLU A 1 253 ? 23.90483  -1.53905  -2.14444  1.000 22.01998 ? 1261 GLU A OE1   1 
ATOM   2195 O OE2   . GLU A 1 253 ? 25.93148  -2.38147  -2.25717  1.000 23.41702 ? 1261 GLU A OE2   1 
ATOM   2196 N N     A ILE A 1 254 ? 22.27500  -7.04737  -4.35537  0.336 13.93842 ? 1262 ILE A N     1 
ATOM   2197 N N     B ILE A 1 254 ? 22.29034  -7.06603  -4.34370  0.664 13.93140 ? 1262 ILE A N     1 
ATOM   2198 C CA    A ILE A 1 254 ? 21.94675  -8.40884  -3.93770  0.336 14.42988 ? 1262 ILE A CA    1 
ATOM   2199 C CA    B ILE A 1 254 ? 22.06089  -8.44419  -3.92048  0.664 14.45220 ? 1262 ILE A CA    1 
ATOM   2200 C C     A ILE A 1 254 ? 22.17741  -9.38759  -5.08153  0.336 14.01605 ? 1262 ILE A C     1 
ATOM   2201 C C     B ILE A 1 254 ? 22.18540  -9.41872  -5.08914  0.664 13.99944 ? 1262 ILE A C     1 
ATOM   2202 O O     A ILE A 1 254 ? 22.80420  -10.43884 -4.90887  0.336 14.56930 ? 1262 ILE A O     1 
ATOM   2203 O O     B ILE A 1 254 ? 22.75195  -10.50679 -4.94020  0.664 14.67504 ? 1262 ILE A O     1 
ATOM   2204 C CB    A ILE A 1 254 ? 20.49689  -8.46915  -3.42043  0.336 14.98921 ? 1262 ILE A CB    1 
ATOM   2205 C CB    B ILE A 1 254 ? 20.73575  -8.59318  -3.15620  0.664 16.34451 ? 1262 ILE A CB    1 
ATOM   2206 C CG1   A ILE A 1 254 ? 20.40899  -7.89551  -2.00845  0.336 18.30614 ? 1262 ILE A CG1   1 
ATOM   2207 C CG1   B ILE A 1 254 ? 19.57219  -8.29057  -4.07888  0.664 9.11329  ? 1262 ILE A CG1   1 
ATOM   2208 C CG2   A ILE A 1 254 ? 19.97895  -9.90085  -3.41687  0.336 12.42156 ? 1262 ILE A CG2   1 
ATOM   2209 C CG2   B ILE A 1 254 ? 20.72788  -7.70244  -1.91503  0.664 18.36106 ? 1262 ILE A CG2   1 
ATOM   2210 C CD1   A ILE A 1 254 ? 18.99058  -7.71933  -1.52398  0.336 24.23741 ? 1262 ILE A CD1   1 
ATOM   2211 C CD1   B ILE A 1 254 ? 18.34683  -7.84024  -3.37639  0.664 27.76221 ? 1262 ILE A CD1   1 
ATOM   2212 N N     . PHE A 1 255 ? 21.67089  -9.05430  -6.27126  1.000 14.29431 ? 1263 PHE A N     1 
ATOM   2213 C CA    . PHE A 1 255 ? 21.83467  -9.94821  -7.42039  1.000 14.95609 ? 1263 PHE A CA    1 
ATOM   2214 C C     . PHE A 1 255 ? 23.30008  -10.11016 -7.80279  1.000 12.98672 ? 1263 PHE A C     1 
ATOM   2215 O O     . PHE A 1 255 ? 23.74320  -11.21714 -8.13677  1.000 13.40139 ? 1263 PHE A O     1 
ATOM   2216 C CB    . PHE A 1 255 ? 20.96156  -9.51708  -8.60973  1.000 15.89677 ? 1263 PHE A CB    1 
ATOM   2217 C CG    . PHE A 1 255 ? 19.58697  -10.14152 -8.59372  1.000 17.98746 ? 1263 PHE A CG    1 
ATOM   2218 C CD1   . PHE A 1 255 ? 18.79860  -10.07947 -7.44773  1.000 20.92206 ? 1263 PHE A CD1   1 
ATOM   2219 C CD2   . PHE A 1 255 ? 19.07474  -10.77732 -9.71964  1.000 17.67311 ? 1263 PHE A CD2   1 
ATOM   2220 C CE1   . PHE A 1 255 ? 17.52669  -10.66076 -7.41042  1.000 19.96158 ? 1263 PHE A CE1   1 
ATOM   2221 C CE2   . PHE A 1 255 ? 17.80391  -11.35292 -9.69198  1.000 19.86127 ? 1263 PHE A CE2   1 
ATOM   2222 C CZ    . PHE A 1 255 ? 17.03063  -11.29185 -8.53720  1.000 20.19861 ? 1263 PHE A CZ    1 
ATOM   2223 N N     . LYS A 1 256 ? 24.08182  -9.01810  -7.73441  1.000 14.28884 ? 1264 LYS A N     1 
ATOM   2224 C CA    . LYS A 1 256 ? 25.51544  -9.13476  -7.97997  1.000 16.76461 ? 1264 LYS A CA    1 
ATOM   2225 C C     . LYS A 1 256 ? 26.17630  -10.06956 -6.97215  1.000 13.17432 ? 1264 LYS A C     1 
ATOM   2226 O O     . LYS A 1 256 ? 27.02376  -10.89221 -7.33958  1.000 14.44616 ? 1264 LYS A O     1 
ATOM   2227 C CB    . LYS A 1 256 ? 26.17907  -7.75883  -7.95791  1.000 18.65387 ? 1264 LYS A CB    1 
ATOM   2228 C CG    . LYS A 1 256 ? 26.11392  -7.03545  -9.30717  1.000 24.88526 ? 1264 LYS A CG    1 
ATOM   2229 C CD    . LYS A 1 256 ? 26.32736  -5.52974  -9.14565  1.000 26.96334 ? 1264 LYS A CD    1 
ATOM   2230 C CE    . LYS A 1 256 ? 26.67142  -4.88363  -10.49204 1.000 28.74824 ? 1264 LYS A CE    1 
ATOM   2231 N NZ    . LYS A 1 256 ? 25.46752  -4.83079  -11.35700 1.000 31.61089 ? 1264 LYS A NZ    1 
ATOM   2232 N N     . LEU A 1 257 ? 25.78351  -9.97103  -5.69165  1.000 13.02552 ? 1265 LEU A N     1 
ATOM   2233 C CA    . LEU A 1 257 ? 26.37725  -10.83714 -4.67441  1.000 13.28528 ? 1265 LEU A CA    1 
ATOM   2234 C C     . LEU A 1 257 ? 26.02757  -12.30391 -4.92183  1.000 11.97173 ? 1265 LEU A C     1 
ATOM   2235 O O     . LEU A 1 257 ? 26.89313  -13.18338 -4.81308  1.000 13.26303 ? 1265 LEU A O     1 
ATOM   2236 C CB    . LEU A 1 257 ? 25.93271  -10.37419 -3.28683  1.000 13.23460 ? 1265 LEU A CB    1 
ATOM   2237 C CG    . LEU A 1 257 ? 26.53001  -9.03460  -2.81308  1.000 14.63457 ? 1265 LEU A CG    1 
ATOM   2238 C CD1   . LEU A 1 257 ? 25.83036  -8.57903  -1.53337  1.000 16.87192 ? 1265 LEU A CD1   1 
ATOM   2239 C CD2   . LEU A 1 257 ? 28.04806  -9.11007  -2.59585  1.000 15.07952 ? 1265 LEU A CD2   1 
ATOM   2240 N N     . LEU A 1 258 ? 24.77300  -12.57338 -5.29877  1.000 13.70187 ? 1266 LEU A N     1 
ATOM   2241 C CA    . LEU A 1 258 ? 24.36818  -13.94134 -5.61072  1.000 14.19331 ? 1266 LEU A CA    1 
ATOM   2242 C C     . LEU A 1 258 ? 25.17437  -14.49265 -6.77651  1.000 13.38594 ? 1266 LEU A C     1 
ATOM   2243 O O     . LEU A 1 258 ? 25.65754  -15.62877 -6.73204  1.000 15.24088 ? 1266 LEU A O     1 
ATOM   2244 C CB    . LEU A 1 258 ? 22.87335  -13.98000 -5.93172  1.000 14.72670 ? 1266 LEU A CB    1 
ATOM   2245 C CG    . LEU A 1 258 ? 21.93582  -13.74460 -4.73796  1.000 11.83450 ? 1266 LEU A CG    1 
ATOM   2246 C CD1   . LEU A 1 258 ? 20.48475  -13.55986 -5.19965  1.000 15.70688 ? 1266 LEU A CD1   1 
ATOM   2247 C CD2   . LEU A 1 258 ? 22.04950  -14.92185 -3.75752  1.000 15.38454 ? 1266 LEU A CD2   1 
ATOM   2248 N N     . ASP A 1 259 ? 25.34410  -13.68234 -7.82702  1.000 13.38614 ? 1267 ASP A N     1 
ATOM   2249 C CA    . ASP A 1 259 ? 26.13941  -14.09645 -8.98114  1.000 15.45261 ? 1267 ASP A CA    1 
ATOM   2250 C C     . ASP A 1 259 ? 27.58454  -14.37322 -8.59505  1.000 13.96397 ? 1267 ASP A C     1 
ATOM   2251 O O     . ASP A 1 259 ? 28.24130  -15.23320 -9.19896  1.000 18.99367 ? 1267 ASP A O     1 
ATOM   2252 C CB    . ASP A 1 259 ? 26.09622  -13.01337 -10.06804 1.000 16.44437 ? 1267 ASP A CB    1 
ATOM   2253 C CG    . ASP A 1 259 ? 24.74646  -12.92599 -10.77109 1.000 18.37108 ? 1267 ASP A CG    1 
ATOM   2254 O OD1   . ASP A 1 259 ? 23.87463  -13.79689 -10.55950 1.000 20.10911 ? 1267 ASP A OD1   1 
ATOM   2255 O OD2   . ASP A 1 259 ? 24.55421  -11.96944 -11.55029 1.000 20.48028 ? 1267 ASP A OD2   1 
ATOM   2256 N N     . GLY A 1 260 ? 28.09325  -13.66587 -7.59235  1.000 13.58279 ? 1268 GLY A N     1 
ATOM   2257 C CA    . GLY A 1 260 ? 29.42859  -13.87872 -7.07718  1.000 16.85275 ? 1268 GLY A CA    1 
ATOM   2258 C C     . GLY A 1 260 ? 29.59753  -15.04089 -6.12699  1.000 16.27475 ? 1268 GLY A C     1 
ATOM   2259 O O     . GLY A 1 260 ? 30.71551  -15.25076 -5.64758  1.000 18.38237 ? 1268 GLY A O     1 
ATOM   2260 N N     . GLY A 1 261 ? 28.53372  -15.78931 -5.82389  1.000 13.79830 ? 1269 GLY A N     1 
ATOM   2261 C CA    . GLY A 1 261 ? 28.61554  -16.95051 -4.95469  1.000 15.26053 ? 1269 GLY A CA    1 
ATOM   2262 C C     . GLY A 1 261 ? 28.01966  -16.80903 -3.56520  1.000 12.60697 ? 1269 GLY A C     1 
ATOM   2263 O O     . GLY A 1 261 ? 28.20960  -17.71434 -2.73732  1.000 13.84621 ? 1269 GLY A O     1 
ATOM   2264 N N     . ALA A 1 262 ? 27.30802  -15.72809 -3.28110  1.000 11.40158 ? 1270 ALA A N     1 
ATOM   2265 C CA    . ALA A 1 262 ? 26.78058  -15.52123 -1.93553  1.000 11.73336 ? 1270 ALA A CA    1 
ATOM   2266 C C     . ALA A 1 262 ? 25.77297  -16.60258 -1.54991  1.000 13.33639 ? 1270 ALA A C     1 
ATOM   2267 O O     . ALA A 1 262 ? 24.99179  -17.08048 -2.38080  1.000 13.17284 ? 1270 ALA A O     1 
ATOM   2268 C CB    . ALA A 1 262 ? 26.10747  -14.16105 -1.83187  1.000 12.40890 ? 1270 ALA A CB    1 
ATOM   2269 N N     . HIS A 1 263 ? 25.79778  -16.98297 -0.27721  1.000 12.93412 ? 1271 HIS A N     1 
ATOM   2270 C CA    . HIS A 1 263 ? 24.74066  -17.79514 0.30665   1.000 11.28795 ? 1271 HIS A CA    1 
ATOM   2271 C C     . HIS A 1 263 ? 23.59245  -16.89334 0.71858   1.000 11.45646 ? 1271 HIS A C     1 
ATOM   2272 O O     . HIS A 1 263 ? 23.80533  -15.76515 1.17585   1.000 12.22935 ? 1271 HIS A O     1 
ATOM   2273 C CB    . HIS A 1 263 ? 25.26747  -18.51041 1.54397   1.000 11.59659 ? 1271 HIS A CB    1 
ATOM   2274 C CG    . HIS A 1 263 ? 26.26070  -19.56323 1.21950   1.000 12.27111 ? 1271 HIS A CG    1 
ATOM   2275 N ND1   . HIS A 1 263 ? 25.89078  -20.81839 0.78686   1.000 12.37622 ? 1271 HIS A ND1   1 
ATOM   2276 C CD2   . HIS A 1 263 ? 27.61369  -19.53004 1.18237   1.000 12.90775 ? 1271 HIS A CD2   1 
ATOM   2277 C CE1   . HIS A 1 263 ? 26.97786  -21.51808 0.51315   1.000 13.20355 ? 1271 HIS A CE1   1 
ATOM   2278 N NE2   . HIS A 1 263 ? 28.03715  -20.75932 0.74903   1.000 12.98048 ? 1271 HIS A NE2   1 
ATOM   2279 N N     . ILE A 1 264 ? 22.36633  -17.38152 0.54450   1.000 12.13728 ? 1272 ILE A N     1 
ATOM   2280 C CA    . ILE A 1 264 ? 21.18361  -16.64119 0.95655   1.000 10.83528 ? 1272 ILE A CA    1 
ATOM   2281 C C     . ILE A 1 264 ? 20.28812  -17.56845 1.77164   1.000 10.44829 ? 1272 ILE A C     1 
ATOM   2282 O O     . ILE A 1 264 ? 20.13264  -18.75174 1.44237   1.000 11.67319 ? 1272 ILE A O     1 
ATOM   2283 C CB    . ILE A 1 264 ? 20.46269  -15.96594 -0.24230  1.000 10.72969 ? 1272 ILE A CB    1 
ATOM   2284 C CG1   . ILE A 1 264 ? 19.33613  -15.05640 0.22661   1.000 12.66334 ? 1272 ILE A CG1   1 
ATOM   2285 C CG2   . ILE A 1 264 ? 19.96637  -16.99797 -1.28153  1.000 11.73567 ? 1272 ILE A CG2   1 
ATOM   2286 C CD1   . ILE A 1 264 ? 18.86709  -14.03911 -0.84051  1.000 12.87948 ? 1272 ILE A CD1   1 
ATOM   2287 N N     . TYR A 1 265 ? 19.74389  -17.03331 2.86796   1.000 10.86745 ? 1273 TYR A N     1 
ATOM   2288 C CA    . TYR A 1 265 ? 19.04041  -17.80774 3.88394   1.000 9.86825  ? 1273 TYR A CA    1 
ATOM   2289 C C     . TYR A 1 265 ? 17.69230  -17.16113 4.13963   1.000 9.72775  ? 1273 TYR A C     1 
ATOM   2290 O O     . TYR A 1 265 ? 17.57454  -15.92853 4.15989   1.000 11.10281 ? 1273 TYR A O     1 
ATOM   2291 C CB    . TYR A 1 265 ? 19.81257  -17.78304 5.23506   1.000 11.08804 ? 1273 TYR A CB    1 
ATOM   2292 C CG    . TYR A 1 265 ? 21.25558  -18.21626 5.14095   1.000 11.68964 ? 1273 TYR A CG    1 
ATOM   2293 C CD1   . TYR A 1 265 ? 22.22547  -17.32459 4.68966   1.000 11.01561 ? 1273 TYR A CD1   1 
ATOM   2294 C CD2   . TYR A 1 265 ? 21.65907  -19.50447 5.50672   1.000 11.56801 ? 1273 TYR A CD2   1 
ATOM   2295 C CE1   . TYR A 1 265 ? 23.54979  -17.70541 4.58215   1.000 12.25005 ? 1273 TYR A CE1   1 
ATOM   2296 C CE2   . TYR A 1 265 ? 22.98824  -19.90116 5.39868   1.000 11.01750 ? 1273 TYR A CE2   1 
ATOM   2297 C CZ    . TYR A 1 265 ? 23.92791  -18.98652 4.94209   1.000 12.47091 ? 1273 TYR A CZ    1 
ATOM   2298 O OH    . TYR A 1 265 ? 25.23980  -19.37881 4.81693   1.000 12.32495 ? 1273 TYR A OH    1 
ATOM   2299 N N     . PHE A 1 266 ? 16.68431  -17.99655 4.38975   1.000 11.30506 ? 1274 PHE A N     1 
ATOM   2300 C CA    . PHE A 1 266 ? 15.35294  -17.51048 4.73366   1.000 10.93063 ? 1274 PHE A CA    1 
ATOM   2301 C C     . PHE A 1 266 ? 14.84556  -18.28330 5.93865   1.000 11.12595 ? 1274 PHE A C     1 
ATOM   2302 O O     . PHE A 1 266 ? 14.91337  -19.51799 5.95316   1.000 12.77854 ? 1274 PHE A O     1 
ATOM   2303 C CB    . PHE A 1 266 ? 14.38012  -17.74003 3.56542   1.000 11.49121 ? 1274 PHE A CB    1 
ATOM   2304 C CG    . PHE A 1 266 ? 14.81186  -17.08155 2.28991   1.000 11.92653 ? 1274 PHE A CG    1 
ATOM   2305 C CD1   . PHE A 1 266 ? 15.67973  -17.73782 1.42612   1.000 12.38228 ? 1274 PHE A CD1   1 
ATOM   2306 C CD2   . PHE A 1 266 ? 14.34995  -15.81708 1.96016   1.000 12.76494 ? 1274 PHE A CD2   1 
ATOM   2307 C CE1   . PHE A 1 266 ? 16.09922  -17.11744 0.23791   1.000 11.88796 ? 1274 PHE A CE1   1 
ATOM   2308 C CE2   . PHE A 1 266 ? 14.76685  -15.19515 0.78413   1.000 12.97195 ? 1274 PHE A CE2   1 
ATOM   2309 C CZ    . PHE A 1 266 ? 15.63862  -15.84878 -0.07451  1.000 12.18191 ? 1274 PHE A CZ    1 
ATOM   2310 N N     . CYS A 1 267 ? 14.32095  -17.56347 6.92692   1.000 11.23015 ? 1275 CYS A N     1 
ATOM   2311 C CA    . CYS A 1 267 ? 13.83419  -18.20390 8.14084   1.000 11.60236 ? 1275 CYS A CA    1 
ATOM   2312 C C     . CYS A 1 267 ? 12.70170  -17.37223 8.72948   1.000 10.03915 ? 1275 CYS A C     1 
ATOM   2313 O O     . CYS A 1 267 ? 12.74151  -16.14025 8.70751   1.000 10.84743 ? 1275 CYS A O     1 
ATOM   2314 C CB    . CYS A 1 267 ? 14.98901  -18.39280 9.14552   1.000 9.78283  ? 1275 CYS A CB    1 
ATOM   2315 S SG    . CYS A 1 267 ? 14.62307  -19.46714 10.54853  1.000 12.75198 ? 1275 CYS A SG    1 
ATOM   2316 N N     . GLY A 1 268 ? 11.69154  -18.07178 9.25392   1.000 11.71778 ? 1276 GLY A N     1 
ATOM   2317 C CA    . GLY A 1 268 ? 10.53099  -17.47687 9.88011   1.000 12.36248 ? 1276 GLY A CA    1 
ATOM   2318 C C     . GLY A 1 268 ? 9.26157   -18.19650 9.43423   1.000 13.01977 ? 1276 GLY A C     1 
ATOM   2319 O O     . GLY A 1 268 ? 9.30091   -19.33619 8.98331   1.000 12.88789 ? 1276 GLY A O     1 
ATOM   2320 N N     . LEU A 1 269 ? 8.12423   -17.52108 9.57718   1.000 18.39144 ? 1277 LEU A N     1 
ATOM   2321 C CA    . LEU A 1 269 ? 6.85743   -18.14499 9.21060   1.000 16.30218 ? 1277 LEU A CA    1 
ATOM   2322 C C     . LEU A 1 269 ? 6.77321   -18.31506 7.69622   1.000 17.04484 ? 1277 LEU A C     1 
ATOM   2323 O O     . LEU A 1 269 ? 7.22113   -17.45833 6.92935   1.000 17.67249 ? 1277 LEU A O     1 
ATOM   2324 C CB    . LEU A 1 269 ? 5.67595   -17.33246 9.74456   1.000 22.37346 ? 1277 LEU A CB    1 
ATOM   2325 C CG    . LEU A 1 269 ? 5.51524   -17.31521 11.27513  1.000 24.37663 ? 1277 LEU A CG    1 
ATOM   2326 C CD1   . LEU A 1 269 ? 4.48882   -16.26833 11.68465  1.000 30.91203 ? 1277 LEU A CD1   1 
ATOM   2327 C CD2   . LEU A 1 269 ? 5.15233   -18.68938 11.83951  1.000 20.10482 ? 1277 LEU A CD2   1 
ATOM   2328 N N     . LYS A 1 270 ? 6.20585   -19.44541 7.27542   1.000 16.54015 ? 1278 LYS A N     1 
ATOM   2329 C CA    . LYS A 1 270 ? 6.24144   -19.82292 5.86361   1.000 15.94883 ? 1278 LYS A CA    1 
ATOM   2330 C C     . LYS A 1 270 ? 5.49273   -18.83529 4.97968   1.000 14.64797 ? 1278 LYS A C     1 
ATOM   2331 O O     . LYS A 1 270 ? 5.83564   -18.68883 3.80054   1.000 16.29430 ? 1278 LYS A O     1 
ATOM   2332 C CB    . LYS A 1 270 ? 5.75131   -21.25797 5.68441   1.000 20.73881 ? 1278 LYS A CB    1 
ATOM   2333 C CG    . LYS A 1 270 ? 4.32526   -21.48773 6.12735   1.000 23.52563 ? 1278 LYS A CG    1 
ATOM   2334 C CD    . LYS A 1 270 ? 3.89456   -22.91288 5.78405   1.000 29.31426 ? 1278 LYS A CD    1 
ATOM   2335 C CE    . LYS A 1 270 ? 3.76166   -23.76066 7.04029   1.000 42.67205 ? 1278 LYS A CE    1 
ATOM   2336 N NZ    . LYS A 1 270 ? 2.96895   -25.00766 6.81714   1.000 52.78749 ? 1278 LYS A NZ    1 
ATOM   2337 N N     . GLY A 1 271 ? 4.52354   -18.10649 5.53724   1.000 16.75573 ? 1279 GLY A N     1 
ATOM   2338 C CA    . GLY A 1 271 ? 3.81286   -17.07351 4.78451   1.000 18.63861 ? 1279 GLY A CA    1 
ATOM   2339 C C     . GLY A 1 271 ? 4.69529   -15.96653 4.23463   1.000 18.55644 ? 1279 GLY A C     1 
ATOM   2340 O O     . GLY A 1 271 ? 4.24559   -15.19075 3.38423   1.000 20.89308 ? 1279 GLY A O     1 
ATOM   2341 N N     . MET A 1 272 ? 5.93622   -15.86589 4.71123   1.000 18.23582 ? 1280 MET A N     1 
ATOM   2342 C CA    . MET A 1 272 ? 6.90607   -14.89980 4.20204   1.000 17.34013 ? 1280 MET A CA    1 
ATOM   2343 C C     . MET A 1 272 ? 7.34105   -15.18167 2.76264   1.000 15.49158 ? 1280 MET A C     1 
ATOM   2344 O O     . MET A 1 272 ? 7.71447   -14.24912 2.04305   1.000 16.98266 ? 1280 MET A O     1 
ATOM   2345 C CB    . MET A 1 272 ? 8.05730   -14.91860 5.21679   1.000 17.30845 ? 1280 MET A CB    1 
ATOM   2346 C CG    . MET A 1 272 ? 9.17731   -15.91768 4.95270   1.000 13.31261 ? 1280 MET A CG    1 
ATOM   2347 S SD    . MET A 1 272 ? 10.42144  -15.84236 6.27427   1.000 15.18314 ? 1280 MET A SD    1 
ATOM   2348 C CE    . MET A 1 272 ? 11.67768  -14.83710 5.47004   1.000 14.98168 ? 1280 MET A CE    1 
ATOM   2349 N N     . MET A 1 273 ? 7.27727   -16.43257 2.32269   1.000 16.20581 ? 1281 MET A N     1 
ATOM   2350 C CA    . MET A 1 273 ? 7.95535   -16.87193 1.10026   1.000 15.13969 ? 1281 MET A CA    1 
ATOM   2351 C C     . MET A 1 273 ? 7.24310   -16.45049 -0.19768  1.000 19.19309 ? 1281 MET A C     1 
ATOM   2352 O O     . MET A 1 273 ? 7.92109   -16.02776 -1.14437  1.000 16.83952 ? 1281 MET A O     1 
ATOM   2353 C CB    . MET A 1 273 ? 8.16571   -18.38375 1.20846   1.000 17.30892 ? 1281 MET A CB    1 
ATOM   2354 C CG    . MET A 1 273 ? 9.48968   -18.85317 1.93154   1.000 16.33121 ? 1281 MET A CG    1 
ATOM   2355 S SD    . MET A 1 273 ? 10.90183  -17.71854 2.06995   1.000 14.85668 ? 1281 MET A SD    1 
ATOM   2356 C CE    . MET A 1 273 ? 11.64930  -18.13203 0.49097   1.000 17.36478 ? 1281 MET A CE    1 
ATOM   2357 N N     . PRO A 1 274 ? 5.90466   -16.54774 -0.30085  1.000 18.20137 ? 1282 PRO A N     1 
ATOM   2358 C CA    . PRO A 1 274 ? 5.25559   -16.15131 -1.57083  1.000 17.80459 ? 1282 PRO A CA    1 
ATOM   2359 C C     . PRO A 1 274 ? 5.56440   -14.73147 -2.02141  1.000 19.19153 ? 1282 PRO A C     1 
ATOM   2360 O O     . PRO A 1 274 ? 5.85132   -14.51403 -3.20994  1.000 20.17950 ? 1282 PRO A O     1 
ATOM   2361 C CB    . PRO A 1 274 ? 3.76393   -16.35833 -1.26331  1.000 21.02712 ? 1282 PRO A CB    1 
ATOM   2362 C CG    . PRO A 1 274 ? 3.77994   -17.57435 -0.37771  1.000 18.02560 ? 1282 PRO A CG    1 
ATOM   2363 C CD    . PRO A 1 274 ? 4.92784   -17.22150 0.58702   1.000 19.70512 ? 1282 PRO A CD    1 
ATOM   2364 N N     . GLY A 1 275 ? 5.51994   -13.75118 -1.11956  1.000 17.35698 ? 1283 GLY A N     1 
ATOM   2365 C CA    . GLY A 1 275 ? 5.84519   -12.38765 -1.50480  1.000 17.07934 ? 1283 GLY A CA    1 
ATOM   2366 C C     . GLY A 1 275 ? 7.30346   -12.21106 -1.86482  1.000 20.26877 ? 1283 GLY A C     1 
ATOM   2367 O O     . GLY A 1 275 ? 7.63890   -11.42937 -2.76224  1.000 18.15329 ? 1283 GLY A O     1 
ATOM   2368 N N     . ILE A 1 276 ? 8.19168   -12.93187 -1.17594  1.000 17.56213 ? 1284 ILE A N     1 
ATOM   2369 C CA    . ILE A 1 276 ? 9.60543   -12.89421 -1.51941  1.000 18.34855 ? 1284 ILE A CA    1 
ATOM   2370 C C     . ILE A 1 276 ? 9.82158   -13.43016 -2.93035  1.000 17.70002 ? 1284 ILE A C     1 
ATOM   2371 O O     . ILE A 1 276 ? 10.50689  -12.80399 -3.74874  1.000 18.07716 ? 1284 ILE A O     1 
ATOM   2372 C CB    . ILE A 1 276 ? 10.42501  -13.64981 -0.45343  1.000 16.19897 ? 1284 ILE A CB    1 
ATOM   2373 C CG1   . ILE A 1 276 ? 10.53068  -12.78266 0.80061   1.000 16.03404 ? 1284 ILE A CG1   1 
ATOM   2374 C CG2   . ILE A 1 276 ? 11.79997  -14.04436 -0.99484  1.000 16.99812 ? 1284 ILE A CG2   1 
ATOM   2375 C CD1   . ILE A 1 276 ? 11.03397  -13.52794 2.05523   1.000 15.65402 ? 1284 ILE A CD1   1 
ATOM   2376 N N     . GLN A 1 277 ? 9.24440   -14.59942 -3.23509  1.000 16.96265 ? 1285 GLN A N     1 
ATOM   2377 C CA    . GLN A 1 277 ? 9.36484   -15.15441 -4.58171  1.000 18.24873 ? 1285 GLN A CA    1 
ATOM   2378 C C     . GLN A 1 277 ? 8.79861   -14.19625 -5.62491  1.000 18.66698 ? 1285 GLN A C     1 
ATOM   2379 O O     . GLN A 1 277 ? 9.38558   -14.02279 -6.69973  1.000 18.75368 ? 1285 GLN A O     1 
ATOM   2380 C CB    . GLN A 1 277 ? 8.66158   -16.51104 -4.66912  1.000 18.15286 ? 1285 GLN A CB    1 
ATOM   2381 C CG    . GLN A 1 277 ? 9.28906   -17.63415 -3.82950  1.000 20.26003 ? 1285 GLN A CG    1 
ATOM   2382 C CD    . GLN A 1 277 ? 10.59914  -18.16670 -4.40638  1.000 21.04400 ? 1285 GLN A CD    1 
ATOM   2383 O OE1   . GLN A 1 277 ? 11.05152  -17.74621 -5.47540  1.000 20.02684 ? 1285 GLN A OE1   1 
ATOM   2384 N NE2   . GLN A 1 277 ? 11.20257  -19.11961 -3.70770  1.000 18.25455 ? 1285 GLN A NE2   1 
ATOM   2385 N N     . ASP A 1 278 ? 7.66534   -13.55947 -5.32266  1.000 18.79228 ? 1286 ASP A N     1 
ATOM   2386 C CA    . ASP A 1 278 ? 7.07618   -12.63499 -6.28902  1.000 22.49516 ? 1286 ASP A CA    1 
ATOM   2387 C C     . ASP A 1 278 ? 8.02060   -11.47214 -6.57717  1.000 22.74535 ? 1286 ASP A C     1 
ATOM   2388 O O     . ASP A 1 278 ? 8.22704   -11.09516 -7.73957  1.000 20.92727 ? 1286 ASP A O     1 
ATOM   2389 C CB    . ASP A 1 278 ? 5.73551   -12.13604 -5.75457  1.000 20.20336 ? 1286 ASP A CB    1 
ATOM   2390 C CG    . ASP A 1 278 ? 5.07958   -11.12614 -6.67661  1.000 29.33069 ? 1286 ASP A CG    1 
ATOM   2391 O OD1   . ASP A 1 278 ? 4.61497   -11.53985 -7.75915  1.000 34.83266 ? 1286 ASP A OD1   1 
ATOM   2392 O OD2   . ASP A 1 278 ? 5.03249   -9.93036  -6.32169  1.000 29.90861 ? 1286 ASP A OD2   1 
ATOM   2393 N N     . THR A 1 279 ? 8.62923   -10.90990 -5.53042  1.000 20.27185 ? 1287 THR A N     1 
ATOM   2394 C CA    . THR A 1 279 ? 9.56828   -9.80886  -5.70290  1.000 17.59113 ? 1287 THR A CA    1 
ATOM   2395 C C     . THR A 1 279 ? 10.81516  -10.25278 -6.46403  1.000 18.68096 ? 1287 THR A C     1 
ATOM   2396 O O     . THR A 1 279 ? 11.29465  -9.54313  -7.36083  1.000 18.43768 ? 1287 THR A O     1 
ATOM   2397 C CB    . THR A 1 279 ? 9.94278   -9.26331  -4.32188  1.000 16.80900 ? 1287 THR A CB    1 
ATOM   2398 O OG1   . THR A 1 279 ? 8.80952   -8.58588  -3.75611  1.000 18.93559 ? 1287 THR A OG1   1 
ATOM   2399 C CG2   . THR A 1 279 ? 11.10926  -8.29903  -4.41476  1.000 18.61233 ? 1287 THR A CG2   1 
ATOM   2400 N N     . LEU A 1 280 ? 11.37491  -11.41074 -6.11733  1.000 15.96630 ? 1288 LEU A N     1 
ATOM   2401 C CA    . LEU A 1 280 ? 12.58464  -11.85345 -6.79999  1.000 17.36662 ? 1288 LEU A CA    1 
ATOM   2402 C C     . LEU A 1 280 ? 12.31732  -12.08973 -8.27998  1.000 16.18195 ? 1288 LEU A C     1 
ATOM   2403 O O     . LEU A 1 280 ? 13.18161  -11.82536 -9.12790  1.000 17.66848 ? 1288 LEU A O     1 
ATOM   2404 C CB    . LEU A 1 280 ? 13.14892  -13.10443 -6.11782  1.000 15.96314 ? 1288 LEU A CB    1 
ATOM   2405 C CG    . LEU A 1 280 ? 13.66640  -12.82884 -4.70382  1.000 17.20714 ? 1288 LEU A CG    1 
ATOM   2406 C CD1   . LEU A 1 280 ? 13.94912  -14.14610 -3.99548  1.000 16.78416 ? 1288 LEU A CD1   1 
ATOM   2407 C CD2   . LEU A 1 280 ? 14.90578  -11.96222 -4.75953  1.000 18.50072 ? 1288 LEU A CD2   1 
ATOM   2408 N N     . LYS A 1 281 ? 11.12133  -12.58214 -8.60879  1.000 17.06577 ? 1289 LYS A N     1 
ATOM   2409 C CA    . LYS A 1 281 ? 10.75403  -12.76711 -10.00835 1.000 17.54132 ? 1289 LYS A CA    1 
ATOM   2410 C C     . LYS A 1 281 ? 10.70801  -11.42657 -10.72751 1.000 17.67852 ? 1289 LYS A C     1 
ATOM   2411 O O     . LYS A 1 281 ? 11.23351  -11.29241 -11.83868 1.000 19.40865 ? 1289 LYS A O     1 
ATOM   2412 C CB    . LYS A 1 281 ? 9.39988   -13.47053 -10.07989 1.000 19.12911 ? 1289 LYS A CB    1 
ATOM   2413 C CG    . LYS A 1 281 ? 8.85279   -13.64943 -11.48769 1.000 29.03649 ? 1289 LYS A CG    1 
ATOM   2414 C CD    . LYS A 1 281 ? 7.44423   -14.21715 -11.46237 1.000 35.13698 ? 1289 LYS A CD    1 
ATOM   2415 C CE    . LYS A 1 281 ? 7.16857   -15.05592 -12.70503 1.000 49.48456 ? 1289 LYS A CE    1 
ATOM   2416 N NZ    . LYS A 1 281 ? 8.32787   -15.92437 -13.07240 1.000 55.88385 ? 1289 LYS A NZ    1 
ATOM   2417 N N     . LYS A 1 282 ? 10.10139  -10.41909 -10.09869 1.000 16.85563 ? 1290 LYS A N     1 
ATOM   2418 C CA    . LYS A 1 282 ? 9.98450   -9.09988  -10.71774 1.000 19.66819 ? 1290 LYS A CA    1 
ATOM   2419 C C     . LYS A 1 282 ? 11.33948  -8.42293  -10.85584 1.000 18.11033 ? 1290 LYS A C     1 
ATOM   2420 O O     . LYS A 1 282 ? 11.62001  -7.78506  -11.87917 1.000 18.81415 ? 1290 LYS A O     1 
ATOM   2421 C CB    . LYS A 1 282 ? 9.01807   -8.22175  -9.92503  1.000 24.28416 ? 1290 LYS A CB    1 
ATOM   2422 C CG    . LYS A 1 282 ? 7.58274   -8.70523  -9.97909  1.000 29.43859 ? 1290 LYS A CG    1 
ATOM   2423 C CD    . LYS A 1 282 ? 6.70726   -8.02608  -8.93689  1.000 38.51602 ? 1290 LYS A CD    1 
ATOM   2424 C CE    . LYS A 1 282 ? 5.25539   -8.48584  -9.07302  1.000 42.66433 ? 1290 LYS A CE    1 
ATOM   2425 N NZ    . LYS A 1 282 ? 4.31918   -7.67649  -8.24201  1.000 40.70425 ? 1290 LYS A NZ    1 
ATOM   2426 N N     . VAL A 1 283 ? 12.19390  -8.54164  -9.84130  1.000 20.05753 ? 1291 VAL A N     1 
ATOM   2427 C CA    . VAL A 1 283 ? 13.54538  -7.99891  -9.94065  1.000 17.18912 ? 1291 VAL A CA    1 
ATOM   2428 C C     . VAL A 1 283 ? 14.29465  -8.63706  -11.10521 1.000 20.18573 ? 1291 VAL A C     1 
ATOM   2429 O O     . VAL A 1 283 ? 14.92898  -7.94364  -11.91406 1.000 18.32159 ? 1291 VAL A O     1 
ATOM   2430 C CB    . VAL A 1 283 ? 14.30000  -8.18785  -8.61355  1.000 18.12443 ? 1291 VAL A CB    1 
ATOM   2431 C CG1   . VAL A 1 283 ? 15.77047  -7.92383  -8.80534  1.000 19.35772 ? 1291 VAL A CG1   1 
ATOM   2432 C CG2   . VAL A 1 283 ? 13.71336  -7.30715  -7.52054  1.000 20.29103 ? 1291 VAL A CG2   1 
ATOM   2433 N N     . ALA A 1 284 ? 14.23787  -9.96886  -11.21261 1.000 16.19691 ? 1292 ALA A N     1 
ATOM   2434 C CA    . ALA A 1 284 ? 14.91931  -10.63925 -12.31336 1.000 15.86278 ? 1292 ALA A CA    1 
ATOM   2435 C C     . ALA A 1 284 ? 14.36911  -10.17674 -13.66008 1.000 15.24602 ? 1292 ALA A C     1 
ATOM   2436 O O     . ALA A 1 284 ? 15.14121  -9.90112  -14.58487 1.000 16.48482 ? 1292 ALA A O     1 
ATOM   2437 C CB    . ALA A 1 284 ? 14.82402  -12.16278 -12.17609 1.000 17.42579 ? 1292 ALA A CB    1 
ATOM   2438 N N     . GLU A 1 285 ? 13.03920  -10.05726 -13.77198 1.000 16.02078 ? 1293 GLU A N     1 
ATOM   2439 C CA    A GLU A 1 285 ? 12.43063  -9.63268  -15.03221 0.523 18.75468 ? 1293 GLU A CA    1 
ATOM   2440 C CA    B GLU A 1 285 ? 12.42052  -9.62605  -15.02687 0.477 18.76485 ? 1293 GLU A CA    1 
ATOM   2441 C C     . GLU A 1 285 ? 12.90481  -8.24151  -15.44109 1.000 18.71892 ? 1293 GLU A C     1 
ATOM   2442 O O     . GLU A 1 285 ? 13.17426  -7.99722  -16.62462 1.000 18.63614 ? 1293 GLU A O     1 
ATOM   2443 C CB    A GLU A 1 285 ? 10.90465  -9.67358  -14.92139 0.523 20.05396 ? 1293 GLU A CB    1 
ATOM   2444 C CB    B GLU A 1 285 ? 10.89615  -9.63163  -14.88534 0.477 20.05593 ? 1293 GLU A CB    1 
ATOM   2445 C CG    A GLU A 1 285 ? 10.15220  -9.65834  -16.25620 0.523 29.73257 ? 1293 GLU A CG    1 
ATOM   2446 C CG    B GLU A 1 285 ? 10.12562  -9.57008  -16.20424 0.477 29.69464 ? 1293 GLU A CG    1 
ATOM   2447 C CD    A GLU A 1 285 ? 10.86515  -10.41956 -17.36062 0.523 31.77685 ? 1293 GLU A CD    1 
ATOM   2448 C CD    B GLU A 1 285 ? 9.90582   -8.15179  -16.70761 0.477 35.00746 ? 1293 GLU A CD    1 
ATOM   2449 O OE1   A GLU A 1 285 ? 10.65286  -11.64591 -17.46997 0.523 37.49307 ? 1293 GLU A OE1   1 
ATOM   2450 O OE1   B GLU A 1 285 ? 9.86152   -7.21479  -15.87806 0.477 31.51113 ? 1293 GLU A OE1   1 
ATOM   2451 O OE2   A GLU A 1 285 ? 11.61662  -9.78996  -18.13645 0.523 39.67152 ? 1293 GLU A OE2   1 
ATOM   2452 O OE2   B GLU A 1 285 ? 9.76220   -7.97827  -17.93880 0.477 36.38514 ? 1293 GLU A OE2   1 
ATOM   2453 N N     . ARG A 1 286 ? 13.00804  -7.31354  -14.48172 1.000 17.69638 ? 1294 ARG A N     1 
ATOM   2454 C CA    . ARG A 1 286 ? 13.48356  -5.96591  -14.80084 1.000 18.40909 ? 1294 ARG A CA    1 
ATOM   2455 C C     . ARG A 1 286 ? 14.91074  -5.98585  -15.30872 1.000 20.51002 ? 1294 ARG A C     1 
ATOM   2456 O O     . ARG A 1 286 ? 15.28636  -5.13538  -16.12355 1.000 20.68120 ? 1294 ARG A O     1 
ATOM   2457 C CB    . ARG A 1 286 ? 13.40938  -5.04072  -13.58443 1.000 22.21782 ? 1294 ARG A CB    1 
ATOM   2458 C CG    . ARG A 1 286 ? 12.02732  -4.55076  -13.24340 1.000 25.61930 ? 1294 ARG A CG    1 
ATOM   2459 C CD    . ARG A 1 286 ? 11.96884  -4.03554  -11.81493 1.000 26.32939 ? 1294 ARG A CD    1 
ATOM   2460 N NE    . ARG A 1 286 ? 10.60000  -4.00232  -11.32520 1.000 33.39517 ? 1294 ARG A NE    1 
ATOM   2461 C CZ    . ARG A 1 286 ? 10.26306  -4.14689  -10.05263 1.000 40.55318 ? 1294 ARG A CZ    1 
ATOM   2462 N NH1   . ARG A 1 286 ? 11.18008  -4.23363  -9.10170  1.000 39.35852 ? 1294 ARG A NH1   1 
ATOM   2463 N NH2   . ARG A 1 286 ? 8.97556   -4.21038  -9.72661  1.000 37.56629 ? 1294 ARG A NH2   1 
ATOM   2464 N N     . ARG A 1 287 ? 15.72313  -6.92689  -14.83288 1.000 16.66252 ? 1295 ARG A N     1 
ATOM   2465 C CA    . ARG A 1 287 ? 17.09424  -7.10075  -15.28228 1.000 18.67917 ? 1295 ARG A CA    1 
ATOM   2466 C C     . ARG A 1 287 ? 17.20433  -7.92177  -16.56012 1.000 17.48708 ? 1295 ARG A C     1 
ATOM   2467 O O     . ARG A 1 287 ? 18.31420  -8.08888  -17.07154 1.000 20.79798 ? 1295 ARG A O     1 
ATOM   2468 C CB    . ARG A 1 287 ? 17.93240  -7.74862  -14.17316 1.000 19.44190 ? 1295 ARG A CB    1 
ATOM   2469 C CG    . ARG A 1 287 ? 17.97751  -6.94969  -12.87268 1.000 22.00994 ? 1295 ARG A CG    1 
ATOM   2470 C CD    . ARG A 1 287 ? 18.51009  -7.79801  -11.71569 1.000 17.73493 ? 1295 ARG A CD    1 
ATOM   2471 N NE    . ARG A 1 287 ? 19.89289  -8.21751  -11.92943 1.000 19.04560 ? 1295 ARG A NE    1 
ATOM   2472 C CZ    . ARG A 1 287 ? 20.95384  -7.46695  -11.65385 1.000 19.99689 ? 1295 ARG A CZ    1 
ATOM   2473 N NH1   . ARG A 1 287 ? 20.82561  -6.25240  -11.14615 1.000 23.39408 ? 1295 ARG A NH1   1 
ATOM   2474 N NH2   . ARG A 1 287 ? 22.17178  -7.95512  -11.87486 1.000 20.51663 ? 1295 ARG A NH2   1 
ATOM   2475 N N     . GLY A 1 288 ? 16.09084  -8.42973  -17.09124 1.000 16.44090 ? 1296 GLY A N     1 
ATOM   2476 C CA    . GLY A 1 288 ? 16.15957  -9.30583  -18.24631 1.000 19.11704 ? 1296 GLY A CA    1 
ATOM   2477 C C     . GLY A 1 288 ? 16.61332  -10.72031 -17.96678 1.000 17.10737 ? 1296 GLY A C     1 
ATOM   2478 O O     . GLY A 1 288 ? 17.11540  -11.39051 -18.87601 1.000 18.39811 ? 1296 GLY A O     1 
ATOM   2479 N N     . GLU A 1 289 ? 16.45104  -11.19711 -16.73110 1.000 18.22987 ? 1297 GLU A N     1 
ATOM   2480 C CA    A GLU A 1 289 ? 16.82619  -12.54594 -16.33636 0.466 18.86082 ? 1297 GLU A CA    1 
ATOM   2481 C CA    B GLU A 1 289 ? 16.82665  -12.54549 -16.32990 0.534 18.85865 ? 1297 GLU A CA    1 
ATOM   2482 C C     . GLU A 1 289 ? 15.58416  -13.35826 -15.98852 1.000 16.20703 ? 1297 GLU A C     1 
ATOM   2483 O O     . GLU A 1 289 ? 14.53857  -12.81682 -15.63792 1.000 19.20145 ? 1297 GLU A O     1 
ATOM   2484 C CB    A GLU A 1 289 ? 17.74514  -12.50686 -15.10899 0.466 19.60494 ? 1297 GLU A CB    1 
ATOM   2485 C CB    B GLU A 1 289 ? 17.72381  -12.51627 -15.08436 0.534 19.56489 ? 1297 GLU A CB    1 
ATOM   2486 C CG    A GLU A 1 289 ? 18.92732  -11.55642 -15.23232 0.466 20.86468 ? 1297 GLU A CG    1 
ATOM   2487 C CG    B GLU A 1 289 ? 19.09499  -11.88443 -15.27576 0.534 20.71545 ? 1297 GLU A CG    1 
ATOM   2488 C CD    A GLU A 1 289 ? 19.88713  -11.68614 -14.06307 0.466 23.36963 ? 1297 GLU A CD    1 
ATOM   2489 C CD    B GLU A 1 289 ? 19.87841  -11.83164 -13.97008 0.534 23.18019 ? 1297 GLU A CD    1 
ATOM   2490 O OE1   A GLU A 1 289 ? 20.80074  -12.53380 -14.13153 0.466 26.03115 ? 1297 GLU A OE1   1 
ATOM   2491 O OE1   B GLU A 1 289 ? 19.84177  -12.82866 -13.21705 0.534 27.63642 ? 1297 GLU A OE1   1 
ATOM   2492 O OE2   A GLU A 1 289 ? 19.71750  -10.94764 -13.07213 0.466 22.88270 ? 1297 GLU A OE2   1 
ATOM   2493 O OE2   B GLU A 1 289 ? 20.51613  -10.79469 -13.69269 0.534 27.30525 ? 1297 GLU A OE2   1 
ATOM   2494 N N     . SER A 1 290 ? 15.72338  -14.67941 -16.07542 1.000 17.95626 ? 1298 SER A N     1 
ATOM   2495 C CA    . SER A 1 290 ? 14.67806  -15.60690 -15.64408 1.000 18.24965 ? 1298 SER A CA    1 
ATOM   2496 C C     . SER A 1 290 ? 14.92979  -15.98557 -14.18589 1.000 16.01236 ? 1298 SER A C     1 
ATOM   2497 O O     . SER A 1 290 ? 15.96366  -16.58684 -13.86883 1.000 16.53773 ? 1298 SER A O     1 
ATOM   2498 C CB    . SER A 1 290 ? 14.71696  -16.86184 -16.51345 1.000 20.59188 ? 1298 SER A CB    1 
ATOM   2499 O OG    . SER A 1 290 ? 14.08794  -17.95565 -15.84914 1.000 20.04251 ? 1298 SER A OG    1 
ATOM   2500 N N     . TRP A 1 291 ? 13.99578  -15.63127 -13.29867 1.000 15.64993 ? 1299 TRP A N     1 
ATOM   2501 C CA    . TRP A 1 291 ? 14.16075  -16.03551 -11.90376 1.000 15.64349 ? 1299 TRP A CA    1 
ATOM   2502 C C     . TRP A 1 291 ? 14.13356  -17.55441 -11.75927 1.000 16.92947 ? 1299 TRP A C     1 
ATOM   2503 O O     . TRP A 1 291 ? 14.87657  -18.11725 -10.94720 1.000 17.51844 ? 1299 TRP A O     1 
ATOM   2504 C CB    . TRP A 1 291 ? 13.13380  -15.36141 -10.99563 1.000 17.13674 ? 1299 TRP A CB    1 
ATOM   2505 C CG    . TRP A 1 291 ? 13.24044  -15.86803 -9.57968  1.000 15.94317 ? 1299 TRP A CG    1 
ATOM   2506 C CD1   . TRP A 1 291 ? 12.28837  -16.55813 -8.88365  1.000 19.34075 ? 1299 TRP A CD1   1 
ATOM   2507 C CD2   . TRP A 1 291 ? 14.37893  -15.75874 -8.70840  1.000 18.58945 ? 1299 TRP A CD2   1 
ATOM   2508 N NE1   . TRP A 1 291 ? 12.76050  -16.87410 -7.63486  1.000 18.14682 ? 1299 TRP A NE1   1 
ATOM   2509 C CE2   . TRP A 1 291 ? 14.03861  -16.39933 -7.49954  1.000 19.19842 ? 1299 TRP A CE2   1 
ATOM   2510 C CE3   . TRP A 1 291 ? 15.64643  -15.17515 -8.82994  1.000 18.43640 ? 1299 TRP A CE3   1 
ATOM   2511 C CZ2   . TRP A 1 291 ? 14.91720  -16.47515 -6.41801  1.000 17.41445 ? 1299 TRP A CZ2   1 
ATOM   2512 C CZ3   . TRP A 1 291 ? 16.52749  -15.25351 -7.75073  1.000 18.61174 ? 1299 TRP A CZ3   1 
ATOM   2513 C CH2   . TRP A 1 291 ? 16.14952  -15.89443 -6.55734  1.000 17.49542 ? 1299 TRP A CH2   1 
ATOM   2514 N N     . ASP A 1 292 ? 13.30834  -18.24399 -12.55150 1.000 17.73647 ? 1300 ASP A N     1 
ATOM   2515 C CA    . ASP A 1 292 ? 13.30464  -19.70645 -12.47876 1.000 17.59801 ? 1300 ASP A CA    1 
ATOM   2516 C C     . ASP A 1 292 ? 14.69461  -20.26919 -12.74397 1.000 17.89277 ? 1300 ASP A C     1 
ATOM   2517 O O     . ASP A 1 292 ? 15.18975  -21.12768 -11.99832 1.000 16.71130 ? 1300 ASP A O     1 
ATOM   2518 C CB    . ASP A 1 292 ? 12.29237  -20.30029 -13.46575 1.000 16.45314 ? 1300 ASP A CB    1 
ATOM   2519 C CG    . ASP A 1 292 ? 10.86183  -20.01689 -13.08232 1.000 23.16247 ? 1300 ASP A CG    1 
ATOM   2520 O OD1   . ASP A 1 292 ? 10.55501  -19.93879 -11.87403 1.000 24.13389 ? 1300 ASP A OD1   1 
ATOM   2521 O OD2   . ASP A 1 292 ? 10.02860  -19.88260 -14.00631 1.000 28.20911 ? 1300 ASP A OD2   1 
ATOM   2522 N N     . GLN A 1 293 ? 15.35355  -19.79017 -13.80105 1.000 17.54371 ? 1301 GLN A N     1 
ATOM   2523 C CA    . GLN A 1 293 ? 16.68233  -20.30294 -14.10038 1.000 14.86840 ? 1301 GLN A CA    1 
ATOM   2524 C C     . GLN A 1 293 ? 17.69298  -19.90193 -13.02819 1.000 13.43185 ? 1301 GLN A C     1 
ATOM   2525 O O     . GLN A 1 293 ? 18.59286  -20.68242 -12.70123 1.000 15.85235 ? 1301 GLN A O     1 
ATOM   2526 C CB    . GLN A 1 293 ? 17.12515  -19.86948 -15.49880 1.000 23.34453 ? 1301 GLN A CB    1 
ATOM   2527 C CG    . GLN A 1 293 ? 16.47171  -20.70984 -16.58782 1.000 27.43995 ? 1301 GLN A CG    1 
ATOM   2528 C CD    . GLN A 1 293 ? 16.46617  -20.02202 -17.94101 1.000 44.81464 ? 1301 GLN A CD    1 
ATOM   2529 O OE1   . GLN A 1 293 ? 17.40964  -19.31395 -18.29438 1.000 48.49412 ? 1301 GLN A OE1   1 
ATOM   2530 N NE2   . GLN A 1 293 ? 15.39382  -20.21854 -18.70073 1.000 49.58747 ? 1301 GLN A NE2   1 
ATOM   2531 N N     . LYS A 1 294 ? 17.56712  -18.69088 -12.48149 1.000 14.50459 ? 1302 LYS A N     1 
ATOM   2532 C CA    . LYS A 1 294 ? 18.50263  -18.26161 -11.44484 1.000 15.46171 ? 1302 LYS A CA    1 
ATOM   2533 C C     . LYS A 1 294 ? 18.33969  -19.09835 -10.17883 1.000 13.61744 ? 1302 LYS A C     1 
ATOM   2534 O O     . LYS A 1 294 ? 19.32895  -19.55452 -9.59374  1.000 15.58348 ? 1302 LYS A O     1 
ATOM   2535 C CB    . LYS A 1 294 ? 18.30608  -16.77960 -11.14275 1.000 17.54870 ? 1302 LYS A CB    1 
ATOM   2536 C CG    . LYS A 1 294 ? 19.42894  -16.17027 -10.32246 1.000 25.14355 ? 1302 LYS A CG    1 
ATOM   2537 C CD    . LYS A 1 294 ? 19.29001  -14.64865 -10.32175 1.000 28.02968 ? 1302 LYS A CD    1 
ATOM   2538 C CE    . LYS A 1 294 ? 20.63238  -13.95957 -10.32745 1.000 25.91346 ? 1302 LYS A CE    1 
ATOM   2539 N NZ    . LYS A 1 294 ? 21.29573  -14.06845 -11.65758 1.000 22.59088 ? 1302 LYS A NZ    1 
ATOM   2540 N N     . LEU A 1 295 ? 17.09163  -19.30877 -9.74711  1.000 13.32766 ? 1303 LEU A N     1 
ATOM   2541 C CA    . LEU A 1 295 ? 16.84538  -20.12205 -8.55848  1.000 13.29791 ? 1303 LEU A CA    1 
ATOM   2542 C C     . LEU A 1 295 ? 17.32610  -21.55723 -8.75801  1.000 14.58273 ? 1303 LEU A C     1 
ATOM   2543 O O     . LEU A 1 295 ? 17.90907  -22.15806 -7.84507  1.000 14.38250 ? 1303 LEU A O     1 
ATOM   2544 C CB    . LEU A 1 295 ? 15.36321  -20.07603 -8.20117  1.000 13.47440 ? 1303 LEU A CB    1 
ATOM   2545 C CG    . LEU A 1 295 ? 14.96162  -20.87643 -6.95325  1.000 11.93509 ? 1303 LEU A CG    1 
ATOM   2546 C CD1   . LEU A 1 295 ? 15.77989  -20.46486 -5.72004  1.000 13.26505 ? 1303 LEU A CD1   1 
ATOM   2547 C CD2   . LEU A 1 295 ? 13.49081  -20.66855 -6.69287  1.000 15.40053 ? 1303 LEU A CD2   1 
ATOM   2548 N N     . ALA A 1 296 ? 17.10666  -22.12818 -9.94831  1.000 13.52027 ? 1304 ALA A N     1 
ATOM   2549 C CA    . ALA A 1 296 ? 17.62851  -23.46568 -10.20772 1.000 14.39863 ? 1304 ALA A CA    1 
ATOM   2550 C C     . ALA A 1 296 ? 19.13698  -23.51706 -10.03836 1.000 14.75013 ? 1304 ALA A C     1 
ATOM   2551 O O     . ALA A 1 296 ? 19.67260  -24.47768 -9.47294  1.000 15.13839 ? 1304 ALA A O     1 
ATOM   2552 C CB    . ALA A 1 296 ? 17.22550  -23.93769 -11.60944 1.000 14.82922 ? 1304 ALA A CB    1 
ATOM   2553 N N     . GLN A 1 297 ? 19.84603  -22.49214 -10.52569 1.000 13.83939 ? 1305 GLN A N     1 
ATOM   2554 C CA    . GLN A 1 297 ? 21.30054  -22.49251 -10.39245 1.000 14.58194 ? 1305 GLN A CA    1 
ATOM   2555 C C     . GLN A 1 297 ? 21.73191  -22.29520 -8.93608  1.000 13.37880 ? 1305 GLN A C     1 
ATOM   2556 O O     . GLN A 1 297 ? 22.69339  -22.92992 -8.48253  1.000 15.54645 ? 1305 GLN A O     1 
ATOM   2557 C CB    . GLN A 1 297 ? 21.91203  -21.40711 -11.27512 1.000 17.85774 ? 1305 GLN A CB    1 
ATOM   2558 C CG    . GLN A 1 297 ? 23.42976  -21.55087 -11.43388 1.000 26.69465 ? 1305 GLN A CG    1 
ATOM   2559 C CD    . GLN A 1 297 ? 23.83318  -22.92020 -12.00468 1.000 33.48322 ? 1305 GLN A CD    1 
ATOM   2560 O OE1   . GLN A 1 297 ? 23.29993  -23.35886 -13.02744 1.000 39.61579 ? 1305 GLN A OE1   1 
ATOM   2561 N NE2   . GLN A 1 297 ? 24.78491  -23.58627 -11.35430 1.000 33.66309 ? 1305 GLN A NE2   1 
ATOM   2562 N N     . LEU A 1 298 ? 21.02857  -21.42815 -8.19136  1.000 13.50114 ? 1306 LEU A N     1 
ATOM   2563 C CA    . LEU A 1 298 ? 21.34831  -21.24140 -6.77522  1.000 13.05741 ? 1306 LEU A CA    1 
ATOM   2564 C C     . LEU A 1 298 ? 21.17003  -22.54050 -5.99809  1.000 14.74248 ? 1306 LEU A C     1 
ATOM   2565 O O     . LEU A 1 298 ? 21.98715  -22.86999 -5.13295  1.000 15.42257 ? 1306 LEU A O     1 
ATOM   2566 C CB    . LEU A 1 298 ? 20.48471  -20.12883 -6.17267  1.000 13.15296 ? 1306 LEU A CB    1 
ATOM   2567 C CG    . LEU A 1 298 ? 20.72681  -18.72301 -6.72808  1.000 13.55434 ? 1306 LEU A CG    1 
ATOM   2568 C CD1   . LEU A 1 298 ? 19.65011  -17.76179 -6.24837  1.000 16.06939 ? 1306 LEU A CD1   1 
ATOM   2569 C CD2   . LEU A 1 298 ? 22.14840  -18.24298 -6.34907  1.000 16.30661 ? 1306 LEU A CD2   1 
ATOM   2570 N N     . LYS A 1 299 ? 20.10787  -23.30022 -6.29508  1.000 13.59104 ? 1307 LYS A N     1 
ATOM   2571 C CA    . LYS A 1 299 ? 19.91383  -24.57622 -5.60849  1.000 12.90682 ? 1307 LYS A CA    1 
ATOM   2572 C C     . LYS A 1 299 ? 20.97911  -25.58912 -6.01969  1.000 13.64144 ? 1307 LYS A C     1 
ATOM   2573 O O     . LYS A 1 299 ? 21.50890  -26.32517 -5.17846  1.000 16.05632 ? 1307 LYS A O     1 
ATOM   2574 C CB    . LYS A 1 299 ? 18.50429  -25.09348 -5.90956  1.000 13.79504 ? 1307 LYS A CB    1 
ATOM   2575 C CG    . LYS A 1 299 ? 17.42233  -24.30444 -5.20581  1.000 14.26436 ? 1307 LYS A CG    1 
ATOM   2576 C CD    . LYS A 1 299 ? 16.01576  -24.90643 -5.39254  1.000 13.49195 ? 1307 LYS A CD    1 
ATOM   2577 C CE    . LYS A 1 299 ? 14.97815  -24.08082 -4.64363  1.000 17.49126 ? 1307 LYS A CE    1 
ATOM   2578 N NZ    . LYS A 1 299 ? 13.75466  -24.84775 -4.26645  1.000 25.43633 ? 1307 LYS A NZ    1 
ATOM   2579 N N     . LYS A 1 300 ? 21.31357  -25.64017 -7.31338  1.000 14.93438 ? 1308 LYS A N     1 
ATOM   2580 C CA    . LYS A 1 300 ? 22.34353  -26.56079 -7.78048  1.000 17.26970 ? 1308 LYS A CA    1 
ATOM   2581 C C     . LYS A 1 300 ? 23.69244  -26.26894 -7.12635  1.000 17.33182 ? 1308 LYS A C     1 
ATOM   2582 O O     . LYS A 1 300 ? 24.44364  -27.19628 -6.79483  1.000 18.69990 ? 1308 LYS A O     1 
ATOM   2583 C CB    . LYS A 1 300 ? 22.45454  -26.46094 -9.30436  1.000 18.64918 ? 1308 LYS A CB    1 
ATOM   2584 C CG    . LYS A 1 300 ? 23.60435  -27.23953 -9.91115  1.000 22.27692 ? 1308 LYS A CG    1 
ATOM   2585 C CD    . LYS A 1 300 ? 23.43709  -27.38561 -11.41706 1.000 29.41488 ? 1308 LYS A CD    1 
ATOM   2586 C CE    . LYS A 1 300 ? 24.58008  -28.18416 -12.01219 1.000 35.75250 ? 1308 LYS A CE    1 
ATOM   2587 N NZ    . LYS A 1 300 ? 25.06533  -27.57189 -13.28083 1.000 53.64636 ? 1308 LYS A NZ    1 
ATOM   2588 N N     . ASN A 1 301 ? 24.01648  -24.98284 -6.94358  1.000 17.85789 ? 1309 ASN A N     1 
ATOM   2589 C CA    . ASN A 1 301 ? 25.26444  -24.51661 -6.34484  1.000 14.91328 ? 1309 ASN A CA    1 
ATOM   2590 C C     . ASN A 1 301 ? 25.24134  -24.54907 -4.81863  1.000 17.29135 ? 1309 ASN A C     1 
ATOM   2591 O O     . ASN A 1 301 ? 26.24191  -24.16061 -4.19679  1.000 17.46629 ? 1309 ASN A O     1 
ATOM   2592 C CB    . ASN A 1 301 ? 25.53662  -23.06625 -6.77558  1.000 17.33958 ? 1309 ASN A CB    1 
ATOM   2593 C CG    . ASN A 1 301 ? 25.88350  -22.92346 -8.25065  1.000 23.21249 ? 1309 ASN A CG    1 
ATOM   2594 O OD1   . ASN A 1 301 ? 26.04395  -23.90647 -8.97536  1.000 27.38483 ? 1309 ASN A OD1   1 
ATOM   2595 N ND2   . ASN A 1 301 ? 25.97020  -21.67533 -8.70657  1.000 23.51954 ? 1309 ASN A ND2   1 
ATOM   2596 N N     . LYS A 1 302 ? 24.12630  -24.97189 -4.21638  1.000 16.33940 ? 1310 LYS A N     1 
ATOM   2597 C CA    A LYS A 1 302 ? 23.98705  -25.07132 -2.75834  0.439 14.45508 ? 1310 LYS A CA    1 
ATOM   2598 C CA    B LYS A 1 302 ? 23.98654  -25.07190 -2.75761  0.561 14.42947 ? 1310 LYS A CA    1 
ATOM   2599 C C     . LYS A 1 302 ? 24.13272  -23.70962 -2.07483  1.000 13.82484 ? 1310 LYS A C     1 
ATOM   2600 O O     . LYS A 1 302 ? 24.72170  -23.59333 -0.99141  1.000 14.78376 ? 1310 LYS A O     1 
ATOM   2601 C CB    A LYS A 1 302 ? 24.91934  -26.12893 -2.15459  0.439 16.70987 ? 1310 LYS A CB    1 
ATOM   2602 C CB    B LYS A 1 302 ? 24.91992  -26.13085 -2.15721  0.561 16.67281 ? 1310 LYS A CB    1 
ATOM   2603 C CG    A LYS A 1 302 ? 24.98049  -27.42277 -2.96969  0.439 20.61001 ? 1310 LYS A CG    1 
ATOM   2604 C CG    B LYS A 1 302 ? 24.85471  -27.48285 -2.88034  0.561 20.61320 ? 1310 LYS A CG    1 
ATOM   2605 C CD    A LYS A 1 302 ? 23.80984  -28.33637 -2.66333  0.439 26.68364 ? 1310 LYS A CD    1 
ATOM   2606 C CD    B LYS A 1 302 ? 25.37376  -28.61606 -2.01023  0.561 24.26451 ? 1310 LYS A CD    1 
ATOM   2607 C CE    A LYS A 1 302 ? 24.10714  -29.23869 -1.47483  0.439 35.19915 ? 1310 LYS A CE    1 
ATOM   2608 C CE    B LYS A 1 302 ? 24.24684  -29.29700 -1.24672  0.561 35.15084 ? 1310 LYS A CE    1 
ATOM   2609 N NZ    A LYS A 1 302 ? 23.87215  -30.67577 -1.79333  0.439 36.65764 ? 1310 LYS A NZ    1 
ATOM   2610 N NZ    B LYS A 1 302 ? 24.05570  -30.71173 -1.67923  0.561 36.79822 ? 1310 LYS A NZ    1 
ATOM   2611 N N     . GLN A 1 303 ? 23.57448  -22.67069 -2.71105  1.000 12.57716 ? 1311 GLN A N     1 
ATOM   2612 C CA    . GLN A 1 303 ? 23.56763  -21.30850 -2.18338  1.000 11.64785 ? 1311 GLN A CA    1 
ATOM   2613 C C     . GLN A 1 303 ? 22.26015  -20.92536 -1.50538  1.000 13.01452 ? 1311 GLN A C     1 
ATOM   2614 O O     . GLN A 1 303 ? 22.17465  -19.82225 -0.95427  1.000 13.06623 ? 1311 GLN A O     1 
ATOM   2615 C CB    . GLN A 1 303 ? 23.81710  -20.28812 -3.31077  1.000 12.33363 ? 1311 GLN A CB    1 
ATOM   2616 C CG    . GLN A 1 303 ? 25.23517  -20.24148 -3.84741  1.000 14.24947 ? 1311 GLN A CG    1 
ATOM   2617 C CD    . GLN A 1 303 ? 25.31140  -19.40518 -5.11233  1.000 15.08006 ? 1311 GLN A CD    1 
ATOM   2618 O OE1   . GLN A 1 303 ? 25.29748  -19.95105 -6.21846  1.000 18.07728 ? 1311 GLN A OE1   1 
ATOM   2619 N NE2   . GLN A 1 303 ? 25.36588  -18.08327 -4.96609  1.000 14.79694 ? 1311 GLN A NE2   1 
ATOM   2620 N N     . TRP A 1 304 ? 21.23089  -21.77431 -1.55427  1.000 12.42857 ? 1312 TRP A N     1 
ATOM   2621 C CA    . TRP A 1 304 ? 19.86204  -21.40228 -1.19644  1.000 10.92329 ? 1312 TRP A CA    1 
ATOM   2622 C C     . TRP A 1 304 ? 19.41038  -22.21095 0.01160   1.000 12.03041 ? 1312 TRP A C     1 
ATOM   2623 O O     . TRP A 1 304 ? 19.29722  -23.43774 -0.07110  1.000 14.75177 ? 1312 TRP A O     1 
ATOM   2624 C CB    . TRP A 1 304 ? 18.94279  -21.69813 -2.39490  1.000 13.70737 ? 1312 TRP A CB    1 
ATOM   2625 C CG    . TRP A 1 304 ? 17.49782  -21.30704 -2.23345  1.000 13.44066 ? 1312 TRP A CG    1 
ATOM   2626 C CD1   . TRP A 1 304 ? 16.46871  -22.11410 -1.81957  1.000 14.97704 ? 1312 TRP A CD1   1 
ATOM   2627 C CD2   . TRP A 1 304 ? 16.91400  -20.02943 -2.52533  1.000 11.85091 ? 1312 TRP A CD2   1 
ATOM   2628 N NE1   . TRP A 1 304 ? 15.28686  -21.40724 -1.83233  1.000 15.14708 ? 1312 TRP A NE1   1 
ATOM   2629 C CE2   . TRP A 1 304 ? 15.53065  -20.12746 -2.25158  1.000 14.28452 ? 1312 TRP A CE2   1 
ATOM   2630 C CE3   . TRP A 1 304 ? 17.42616  -18.81278 -2.99703  1.000 12.67818 ? 1312 TRP A CE3   1 
ATOM   2631 C CZ2   . TRP A 1 304 ? 14.65588  -19.05539 -2.42172  1.000 13.95596 ? 1312 TRP A CZ2   1 
ATOM   2632 C CZ3   . TRP A 1 304 ? 16.54826  -17.74463 -3.17569  1.000 15.41151 ? 1312 TRP A CZ3   1 
ATOM   2633 C CH2   . TRP A 1 304 ? 15.17659  -17.88191 -2.89330  1.000 15.05563 ? 1312 TRP A CH2   1 
ATOM   2634 N N     . HIS A 1 305 ? 19.13986  -21.53046 1.12590   1.000 12.23223 ? 1313 HIS A N     1 
ATOM   2635 C CA    . HIS A 1 305 ? 18.91710  -22.21179 2.40455   1.000 11.18559 ? 1313 HIS A CA    1 
ATOM   2636 C C     . HIS A 1 305 ? 17.63832  -21.69018 3.04339   1.000 11.11096 ? 1313 HIS A C     1 
ATOM   2637 O O     . HIS A 1 305 ? 17.59654  -20.53951 3.48337   1.000 14.67900 ? 1313 HIS A O     1 
ATOM   2638 C CB    . HIS A 1 305 ? 20.11760  -21.97498 3.32649   1.000 13.83686 ? 1313 HIS A CB    1 
ATOM   2639 C CG    . HIS A 1 305 ? 21.43959  -22.13823 2.63967   1.000 13.08947 ? 1313 HIS A CG    1 
ATOM   2640 N ND1   . HIS A 1 305 ? 21.90751  -23.36517 2.21831   1.000 13.20949 ? 1313 HIS A ND1   1 
ATOM   2641 C CD2   . HIS A 1 305 ? 22.36606  -21.22507 2.24614   1.000 12.47047 ? 1313 HIS A CD2   1 
ATOM   2642 C CE1   . HIS A 1 305 ? 23.08162  -23.20719 1.62427   1.000 13.76745 ? 1313 HIS A CE1   1 
ATOM   2643 N NE2   . HIS A 1 305 ? 23.38333  -21.91870 1.63284   1.000 13.78683 ? 1313 HIS A NE2   1 
ATOM   2644 N N     . VAL A 1 306 ? 16.60592  -22.53979 3.12953   1.000 12.69239 ? 1314 VAL A N     1 
ATOM   2645 C CA    . VAL A 1 306 ? 15.27943  -22.12665 3.60184   1.000 13.55078 ? 1314 VAL A CA    1 
ATOM   2646 C C     . VAL A 1 306 ? 14.83419  -23.01293 4.76158   1.000 12.76804 ? 1314 VAL A C     1 
ATOM   2647 O O     . VAL A 1 306 ? 14.82568  -24.24370 4.64142   1.000 14.91373 ? 1314 VAL A O     1 
ATOM   2648 C CB    . VAL A 1 306 ? 14.22741  -22.17129 2.47247   1.000 12.24138 ? 1314 VAL A CB    1 
ATOM   2649 C CG1   . VAL A 1 306 ? 12.85072  -21.84957 3.02153   1.000 13.18497 ? 1314 VAL A CG1   1 
ATOM   2650 C CG2   . VAL A 1 306 ? 14.58671  -21.18607 1.36686   1.000 15.76957 ? 1314 VAL A CG2   1 
ATOM   2651 N N     . GLU A 1 307 ? 14.43963  -22.38667 5.86556   1.000 11.08922 ? 1315 GLU A N     1 
ATOM   2652 C CA    . GLU A 1 307 ? 13.82316  -23.11503 6.97728   1.000 11.48514 ? 1315 GLU A CA    1 
ATOM   2653 C C     . GLU A 1 307 ? 12.67975  -22.25193 7.49413   1.000 12.52869 ? 1315 GLU A C     1 
ATOM   2654 O O     . GLU A 1 307 ? 12.88828  -21.31480 8.27253   1.000 13.98421 ? 1315 GLU A O     1 
ATOM   2655 C CB    . GLU A 1 307 ? 14.83980  -23.46252 8.05659   1.000 13.33325 ? 1315 GLU A CB    1 
ATOM   2656 C CG    . GLU A 1 307 ? 14.24470  -24.33594 9.16896   1.000 15.96369 ? 1315 GLU A CG    1 
ATOM   2657 C CD    . GLU A 1 307 ? 15.25731  -25.29738 9.74923   1.000 19.80516 ? 1315 GLU A CD    1 
ATOM   2658 O OE1   . GLU A 1 307 ? 16.07170  -24.87832 10.59403  1.000 23.86374 ? 1315 GLU A OE1   1 
ATOM   2659 O OE2   . GLU A 1 307 ? 15.23200  -26.47435 9.33945   1.000 27.70247 ? 1315 GLU A OE2   1 
ATOM   2660 N N     . VAL A 1 308 ? 11.46512  -22.53016 6.99950   1.000 13.94130 ? 1316 VAL A N     1 
ATOM   2661 C CA    . VAL A 1 308 ? 10.28579  -21.76727 7.37634   1.000 13.54792 ? 1316 VAL A CA    1 
ATOM   2662 C C     . VAL A 1 308 ? 9.21553   -22.71699 7.90036   1.000 13.19281 ? 1316 VAL A C     1 
ATOM   2663 O O     . VAL A 1 308 ? 9.25380   -23.92216 7.65398   1.000 15.78699 ? 1316 VAL A O     1 
ATOM   2664 C CB    . VAL A 1 308 ? 9.74440   -20.90320 6.22368   1.000 13.10329 ? 1316 VAL A CB    1 
ATOM   2665 C CG1   . VAL A 1 308 ? 10.77794  -19.84097 5.83773   1.000 14.90768 ? 1316 VAL A CG1   1 
ATOM   2666 C CG2   . VAL A 1 308 ? 9.35600   -21.77553 5.02052   1.000 14.33966 ? 1316 VAL A CG2   1 
ATOM   2667 N N     . TYR A 1 309 ? 8.27123   -22.15716 8.64892   1.000 13.26797 ? 1317 TYR A N     1 
ATOM   2668 C CA    . TYR A 1 309 ? 7.40369   -22.99614 9.47910   1.000 13.78260 ? 1317 TYR A CA    1 
ATOM   2669 C C     . TYR A 1 309 ? 6.06919   -22.33728 9.79626   1.000 20.23452 ? 1317 TYR A C     1 
ATOM   2670 O O     . TYR A 1 309 ? 5.78654   -21.21755 9.39153   1.000 18.21783 ? 1317 TYR A O     1 
ATOM   2671 C CB    . TYR A 1 309 ? 8.12514   -23.35169 10.79034  1.000 14.37438 ? 1317 TYR A CB    1 
ATOM   2672 C CG    . TYR A 1 309 ? 8.86113   -22.19253 11.44133  1.000 12.84827 ? 1317 TYR A CG    1 
ATOM   2673 C CD1   . TYR A 1 309 ? 8.19345   -21.28453 12.24804  1.000 11.65463 ? 1317 TYR A CD1   1 
ATOM   2674 C CD2   . TYR A 1 309 ? 10.23794  -22.02000 11.25344  1.000 13.04600 ? 1317 TYR A CD2   1 
ATOM   2675 C CE1   . TYR A 1 309 ? 8.84913   -20.23353 12.84562  1.000 13.73034 ? 1317 TYR A CE1   1 
ATOM   2676 C CE2   . TYR A 1 309 ? 10.90678  -20.95995 11.84496  1.000 13.19331 ? 1317 TYR A CE2   1 
ATOM   2677 C CZ    . TYR A 1 309 ? 10.20956  -20.07226 12.63997  1.000 12.46156 ? 1317 TYR A CZ    1 
ATOM   2678 O OH    . TYR A 1 309 ? 10.86607  -19.01966 13.25492  1.000 13.46338 ? 1317 TYR A OH    1 
ATOM   2679 O OXT   . TYR A 1 309 ? 5.23864   -22.92990 10.50195  1.000 23.37952 ? 1317 TYR A OXT   1 
HETATM 2680 P PA    . FAD B 2 .   ? 0.22090   -25.80073 19.05377  1.000 14.75610 ? 1401 FAD A PA    1 
HETATM 2681 O O1A   . FAD B 2 .   ? 0.95522   -26.80003 18.26543  1.000 15.21523 ? 1401 FAD A O1A   1 
HETATM 2682 O O2A   . FAD B 2 .   ? -0.39931  -26.22904 20.32716  1.000 15.33237 ? 1401 FAD A O2A   1 
HETATM 2683 O O5B   . FAD B 2 .   ? -0.91810  -25.14045 18.14941  1.000 13.76192 ? 1401 FAD A O5B   1 
HETATM 2684 C C5B   . FAD B 2 .   ? -0.62603  -24.77902 16.77763  1.000 14.26545 ? 1401 FAD A C5B   1 
HETATM 2685 C C4B   . FAD B 2 .   ? -1.44785  -23.56380 16.41634  1.000 16.19868 ? 1401 FAD A C4B   1 
HETATM 2686 O O4B   . FAD B 2 .   ? -2.85379  -23.92021 16.37630  1.000 16.51037 ? 1401 FAD A O4B   1 
HETATM 2687 C C3B   . FAD B 2 .   ? -1.33449  -22.37194 17.36938  1.000 15.27740 ? 1401 FAD A C3B   1 
HETATM 2688 O O3B   . FAD B 2 .   ? -1.28189  -21.13957 16.65715  1.000 17.70104 ? 1401 FAD A O3B   1 
HETATM 2689 C C2B   . FAD B 2 .   ? -2.62983  -22.45426 18.17949  1.000 13.44547 ? 1401 FAD A C2B   1 
HETATM 2690 O O2B   . FAD B 2 .   ? -3.00729  -21.17629 18.67727  1.000 17.26663 ? 1401 FAD A O2B   1 
HETATM 2691 C C1B   . FAD B 2 .   ? -3.59287  -22.96768 17.11264  1.000 14.64613 ? 1401 FAD A C1B   1 
HETATM 2692 N N9A   . FAD B 2 .   ? -4.78583  -23.62855 17.62976  1.000 17.17801 ? 1401 FAD A N9A   1 
HETATM 2693 C C8A   . FAD B 2 .   ? -4.84617  -24.60313 18.59020  1.000 22.41416 ? 1401 FAD A C8A   1 
HETATM 2694 N N7A   . FAD B 2 .   ? -6.05094  -25.08226 18.79089  1.000 21.86038 ? 1401 FAD A N7A   1 
HETATM 2695 C C5A   . FAD B 2 .   ? -6.83974  -24.37260 17.89924  1.000 20.05478 ? 1401 FAD A C5A   1 
HETATM 2696 C C6A   . FAD B 2 .   ? -8.21468  -24.42951 17.59382  1.000 23.51317 ? 1401 FAD A C6A   1 
HETATM 2697 N N6A   . FAD B 2 .   ? -9.06729  -25.27918 18.17361  1.000 27.51624 ? 1401 FAD A N6A   1 
HETATM 2698 N N1A   . FAD B 2 .   ? -8.67944  -23.60060 16.63505  1.000 24.74586 ? 1401 FAD A N1A   1 
HETATM 2699 C C2A   . FAD B 2 .   ? -7.82180  -22.77709 16.02272  1.000 25.10616 ? 1401 FAD A C2A   1 
HETATM 2700 N N3A   . FAD B 2 .   ? -6.50631  -22.63763 16.22538  1.000 22.46179 ? 1401 FAD A N3A   1 
HETATM 2701 C C4A   . FAD B 2 .   ? -6.07496  -23.47046 17.17704  1.000 19.31799 ? 1401 FAD A C4A   1 
HETATM 2702 N N1    . FAD B 2 .   ? 8.52124   -20.98371 16.64498  1.000 11.78429 ? 1401 FAD A N1    1 
HETATM 2703 C C2    . FAD B 2 .   ? 9.03559   -19.92913 17.35655  1.000 11.40239 ? 1401 FAD A C2    1 
HETATM 2704 O O2    . FAD B 2 .   ? 8.32006   -19.19185 18.04486  1.000 13.30206 ? 1401 FAD A O2    1 
HETATM 2705 N N3    . FAD B 2 .   ? 10.40476  -19.64851 17.30609  1.000 12.40621 ? 1401 FAD A N3    1 
HETATM 2706 C C4    . FAD B 2 .   ? 11.34692  -20.34459 16.57343  1.000 12.43128 ? 1401 FAD A C4    1 
HETATM 2707 O O4    . FAD B 2 .   ? 12.52193  -19.95627 16.53906  1.000 12.21339 ? 1401 FAD A O4    1 
HETATM 2708 C C4X   . FAD B 2 .   ? 10.80835  -21.47270 15.83620  1.000 10.45651 ? 1401 FAD A C4X   1 
HETATM 2709 N N5    . FAD B 2 .   ? 11.63217  -22.20268 15.13960  1.000 11.28919 ? 1401 FAD A N5    1 
HETATM 2710 C C5X   . FAD B 2 .   ? 11.11725  -23.28952 14.44747  1.000 10.68998 ? 1401 FAD A C5X   1 
HETATM 2711 C C6    . FAD B 2 .   ? 11.99946  -24.07938 13.70429  1.000 11.16608 ? 1401 FAD A C6    1 
HETATM 2712 C C7    . FAD B 2 .   ? 11.54338  -25.17534 12.98128  1.000 11.17759 ? 1401 FAD A C7    1 
HETATM 2713 C C7M   . FAD B 2 .   ? 12.52907  -26.01993 12.21095  1.000 13.28050 ? 1401 FAD A C7M   1 
HETATM 2714 C C8    . FAD B 2 .   ? 10.16669  -25.49298 12.99777  1.000 12.43902 ? 1401 FAD A C8    1 
HETATM 2715 C C8M   . FAD B 2 .   ? 9.63051   -26.66550 12.21468  1.000 13.11976 ? 1401 FAD A C8M   1 
HETATM 2716 C C9    . FAD B 2 .   ? 9.28757   -24.70632 13.73846  1.000 11.01780 ? 1401 FAD A C9    1 
HETATM 2717 C C9A   . FAD B 2 .   ? 9.74626   -23.61321 14.46724  1.000 10.18508 ? 1401 FAD A C9A   1 
HETATM 2718 N N10   . FAD B 2 .   ? 8.88379   -22.80472 15.25195  1.000 10.66020 ? 1401 FAD A N10   1 
HETATM 2719 C C10   . FAD B 2 .   ? 9.36675   -21.71923 15.93731  1.000 10.15040 ? 1401 FAD A C10   1 
HETATM 2720 C "C1'" . FAD B 2 .   ? 7.45753   -23.15256 15.41768  1.000 11.58247 ? 1401 FAD A "C1'" 1 
HETATM 2721 C "C2'" . FAD B 2 .   ? 7.27373   -24.08020 16.62092  1.000 10.72540 ? 1401 FAD A "C2'" 1 
HETATM 2722 O "O2'" . FAD B 2 .   ? 7.83120   -25.36236 16.34364  1.000 11.83429 ? 1401 FAD A "O2'" 1 
HETATM 2723 C "C3'" . FAD B 2 .   ? 5.78479   -24.27244 16.93408  1.000 11.81255 ? 1401 FAD A "C3'" 1 
HETATM 2724 O "O3'" . FAD B 2 .   ? 5.06824   -24.76080 15.80087  1.000 15.12545 ? 1401 FAD A "O3'" 1 
HETATM 2725 C "C4'" . FAD B 2 .   ? 5.08578   -23.02309 17.47468  1.000 12.31233 ? 1401 FAD A "C4'" 1 
HETATM 2726 O "O4'" . FAD B 2 .   ? 5.75834   -22.55312 18.64221  1.000 12.48573 ? 1401 FAD A "O4'" 1 
HETATM 2727 C "C5'" . FAD B 2 .   ? 3.63721   -23.30398 17.83165  1.000 13.76264 ? 1401 FAD A "C5'" 1 
HETATM 2728 O "O5'" . FAD B 2 .   ? 3.60728   -24.43157 18.73857  1.000 13.06357 ? 1401 FAD A "O5'" 1 
HETATM 2729 P P     . FAD B 2 .   ? 2.62011   -24.46197 19.99234  1.000 12.62149 ? 1401 FAD A P     1 
HETATM 2730 O O1P   . FAD B 2 .   ? 2.87229   -25.73856 20.69345  1.000 13.37581 ? 1401 FAD A O1P   1 
HETATM 2731 O O2P   . FAD B 2 .   ? 2.67075   -23.19759 20.74356  1.000 12.37792 ? 1401 FAD A O2P   1 
HETATM 2732 O O3P   . FAD B 2 .   ? 1.18235   -24.54190 19.28082  1.000 13.09448 ? 1401 FAD A O3P   1 
HETATM 2733 O O1    . MES C 3 .   ? 35.79629  -7.10391  2.22209   1.000 39.94133 ? 1402 MES A O1    1 
HETATM 2734 C C2    . MES C 3 .   ? 34.85425  -7.61186  3.16445   1.000 25.39089 ? 1402 MES A C2    1 
HETATM 2735 C C3    . MES C 3 .   ? 33.41611  -7.35541  2.72065   1.000 25.36629 ? 1402 MES A C3    1 
HETATM 2736 N N4    . MES C 3 .   ? 33.26733  -5.97439  2.26123   1.000 30.50125 ? 1402 MES A N4    1 
HETATM 2737 C C5    . MES C 3 .   ? 34.22908  -5.50620  1.27055   1.000 32.48065 ? 1402 MES A C5    1 
HETATM 2738 C C6    . MES C 3 .   ? 35.59157  -5.72337  1.91670   1.000 31.90109 ? 1402 MES A C6    1 
HETATM 2739 C C7    . MES C 3 .   ? 31.87962  -5.50956  2.16052   1.000 30.01592 ? 1402 MES A C7    1 
HETATM 2740 C C8    . MES C 3 .   ? 31.84598  -4.08040  1.62406   1.000 37.01576 ? 1402 MES A C8    1 
HETATM 2741 S S     . MES C 3 .   ? 30.30838  -3.44674  1.79981   1.000 46.94228 ? 1402 MES A S     1 
HETATM 2742 O O1S   . MES C 3 .   ? 30.32190  -2.01756  1.40246   1.000 53.80265 ? 1402 MES A O1S   1 
HETATM 2743 O O2S   . MES C 3 .   ? 29.91369  -3.54096  3.22412   1.000 43.80874 ? 1402 MES A O2S   1 
HETATM 2744 O O3S   . MES C 3 .   ? 29.33424  -4.16894  0.93924   1.000 37.48252 ? 1402 MES A O3S   1 
HETATM 2745 O O1    . MES D 3 .   ? 21.15261  3.70554   -0.88448  1.000 48.39689 ? 1403 MES A O1    1 
HETATM 2746 C C2    . MES D 3 .   ? 20.16200  2.73580   -1.21489  1.000 42.31387 ? 1403 MES A C2    1 
HETATM 2747 C C3    . MES D 3 .   ? 20.73814  1.64860   -2.11730  1.000 36.75231 ? 1403 MES A C3    1 
HETATM 2748 N N4    . MES D 3 .   ? 21.48738  2.25211   -3.21759  1.000 45.82040 ? 1403 MES A N4    1 
HETATM 2749 C C5    . MES D 3 .   ? 22.35078  3.41189   -2.99295  1.000 42.41491 ? 1403 MES A C5    1 
HETATM 2750 C C6    . MES D 3 .   ? 21.65111  4.37626   -2.03695  1.000 45.20110 ? 1403 MES A C6    1 
HETATM 2751 C C7    . MES D 3 .   ? 21.78299  1.43577   -4.39747  1.000 29.70427 ? 1403 MES A C7    1 
HETATM 2752 C C8    . MES D 3 .   ? 21.30336  0.00377   -4.13971  1.000 26.54380 ? 1403 MES A C8    1 
HETATM 2753 S S     . MES D 3 .   ? 21.39191  -0.83408  -5.58771  1.000 33.44863 ? 1403 MES A S     1 
HETATM 2754 O O1S   . MES D 3 .   ? 21.23898  -2.28850  -5.31371  1.000 22.13785 ? 1403 MES A O1S   1 
HETATM 2755 O O2S   . MES D 3 .   ? 22.71632  -0.60070  -6.20512  1.000 30.34250 ? 1403 MES A O2S   1 
HETATM 2756 O O3S   . MES D 3 .   ? 20.30155  -0.38503  -6.48625  1.000 36.78767 ? 1403 MES A O3S   1 
HETATM 2757 O O     . HOH E 4 .   ? 7.15656   -32.70769 29.12458  1.000 28.72050 ? 1501 HOH A O     1 
HETATM 2758 O O     A HOH E 4 .   ? 18.765    -1.695    -7.296    0.464 23.22681 ? 1502 HOH A O     1 
HETATM 2759 O O     B HOH E 4 .   ? 17.564    -1.207    -6.453    0.536 22.60402 ? 1502 HOH A O     1 
HETATM 2760 O O     . HOH E 4 .   ? 27.02602  -19.19919 34.27645  1.000 38.21566 ? 1503 HOH A O     1 
HETATM 2761 O O     . HOH E 4 .   ? 8.88453   -2.28097  -3.26199  1.000 33.52011 ? 1504 HOH A O     1 
HETATM 2762 O O     . HOH E 4 .   ? 11.44224  -1.42096  -2.70518  1.000 31.03836 ? 1505 HOH A O     1 
HETATM 2763 O O     . HOH E 4 .   ? 23.64216  -28.16691 34.00531  1.000 25.00946 ? 1506 HOH A O     1 
HETATM 2764 O O     . HOH E 4 .   ? 24.07130  -14.04532 30.57397  1.000 41.10266 ? 1507 HOH A O     1 
HETATM 2765 O O     . HOH E 4 .   ? 22.25101  -10.61884 -12.07143 1.000 32.54643 ? 1508 HOH A O     1 
HETATM 2766 O O     . HOH E 4 .   ? 13.79666  0.73181   8.41025   1.000 34.58865 ? 1509 HOH A O     1 
HETATM 2767 O O     . HOH E 4 .   ? 7.84968   -11.70233 3.29086   1.000 23.78845 ? 1510 HOH A O     1 
HETATM 2768 O O     . HOH E 4 .   ? 40.35907  -29.65235 18.27863  1.000 42.31443 ? 1511 HOH A O     1 
HETATM 2769 O O     . HOH E 4 .   ? 36.46683  -27.49430 13.52104  1.000 36.47473 ? 1512 HOH A O     1 
HETATM 2770 O O     . HOH E 4 .   ? -21.64581 -12.08460 12.30179  1.000 37.42365 ? 1513 HOH A O     1 
HETATM 2771 O O     . HOH E 4 .   ? 17.35438  -25.95032 12.41761  1.000 23.84818 ? 1514 HOH A O     1 
HETATM 2772 O O     . HOH E 4 .   ? -4.34620  -25.32335 22.20512  1.000 31.97935 ? 1515 HOH A O     1 
HETATM 2773 O O     . HOH E 4 .   ? 9.01107   -5.95547  -3.38025  1.000 27.84835 ? 1516 HOH A O     1 
HETATM 2774 O O     . HOH E 4 .   ? 0.96363   -3.75545  25.41589  1.000 47.85223 ? 1517 HOH A O     1 
HETATM 2775 O O     . HOH E 4 .   ? 0.34258   -29.12150 28.56655  1.000 22.30260 ? 1518 HOH A O     1 
HETATM 2776 O O     . HOH E 4 .   ? 17.01664  0.50531   5.49526   1.000 25.54919 ? 1519 HOH A O     1 
HETATM 2777 O O     . HOH E 4 .   ? 2.38139   -37.95462 20.85371  1.000 38.18114 ? 1520 HOH A O     1 
HETATM 2778 O O     . HOH E 4 .   ? 31.10577  -24.45669 1.37381   1.000 38.49414 ? 1521 HOH A O     1 
HETATM 2779 O O     . HOH E 4 .   ? 8.14504   -38.20994 25.00363  1.000 33.28582 ? 1522 HOH A O     1 
HETATM 2780 O O     . HOH E 4 .   ? 36.75065  -2.17730  1.87882   1.000 19.58753 ? 1523 HOH A O     1 
HETATM 2781 O O     . HOH E 4 .   ? 31.45617  -25.59794 7.10211   1.000 20.00790 ? 1524 HOH A O     1 
HETATM 2782 O O     . HOH E 4 .   ? -16.51526 -14.86366 20.04785  1.000 25.53834 ? 1525 HOH A O     1 
HETATM 2783 O O     . HOH E 4 .   ? 38.67966  -23.61229 4.64488   1.000 37.88002 ? 1526 HOH A O     1 
HETATM 2784 O O     . HOH E 4 .   ? -13.92206 -18.70031 18.15312  1.000 27.98193 ? 1527 HOH A O     1 
HETATM 2785 O O     . HOH E 4 .   ? 13.34292  -19.44172 13.81286  1.000 13.43148 ? 1528 HOH A O     1 
HETATM 2786 O O     . HOH E 4 .   ? 14.43415  -36.95393 31.00667  1.000 33.22060 ? 1529 HOH A O     1 
HETATM 2787 O O     . HOH E 4 .   ? -8.68178  -9.00509  20.84113  1.000 39.07253 ? 1530 HOH A O     1 
HETATM 2788 O O     . HOH E 4 .   ? 17.27861  -28.06309 9.15001   1.000 23.51048 ? 1531 HOH A O     1 
HETATM 2789 O O     . HOH E 4 .   ? 34.04124  -13.67812 15.88467  1.000 13.58999 ? 1532 HOH A O     1 
HETATM 2790 O O     . HOH E 4 .   ? 29.43725  -5.38034  -1.38555  1.000 41.91344 ? 1533 HOH A O     1 
HETATM 2791 O O     . HOH E 4 .   ? 21.79846  -37.86553 30.13601  1.000 29.05116 ? 1534 HOH A O     1 
HETATM 2792 O O     . HOH E 4 .   ? 24.01070  1.02694   -1.58018  1.000 30.96306 ? 1535 HOH A O     1 
HETATM 2793 O O     . HOH E 4 .   ? 25.89192  -20.72302 32.18233  1.000 24.40225 ? 1536 HOH A O     1 
HETATM 2794 O O     . HOH E 4 .   ? 5.79816   -25.71125 13.45178  1.000 27.87274 ? 1537 HOH A O     1 
HETATM 2795 O O     . HOH E 4 .   ? 8.38456   -8.65715  6.24839   1.000 20.81307 ? 1538 HOH A O     1 
HETATM 2796 O O     . HOH E 4 .   ? 23.28530  -24.12778 5.06822   1.000 17.42413 ? 1539 HOH A O     1 
HETATM 2797 O O     . HOH E 4 .   ? 26.27239  -20.31369 27.64875  1.000 10.60424 ? 1540 HOH A O     1 
HETATM 2798 O O     . HOH E 4 .   ? 4.32574   -13.45432 1.39068   1.000 22.69542 ? 1541 HOH A O     1 
HETATM 2799 O O     . HOH E 4 .   ? 6.24908   -10.28410 19.20089  1.000 18.89229 ? 1542 HOH A O     1 
HETATM 2800 O O     . HOH E 4 .   ? 38.32251  -9.43613  4.40230   1.000 34.48577 ? 1543 HOH A O     1 
HETATM 2801 O O     . HOH E 4 .   ? 28.44135  -22.31554 12.43576  1.000 18.15485 ? 1544 HOH A O     1 
HETATM 2802 O O     . HOH E 4 .   ? 27.92795  -1.35583  7.41727   1.000 16.13172 ? 1545 HOH A O     1 
HETATM 2803 O O     . HOH E 4 .   ? 40.14124  -13.85105 24.02126  1.000 33.28058 ? 1546 HOH A O     1 
HETATM 2804 O O     . HOH E 4 .   ? 13.84740  -20.18462 18.96315  1.000 12.17252 ? 1547 HOH A O     1 
HETATM 2805 O O     . HOH E 4 .   ? 7.68212   -16.29804 32.23976  1.000 17.10389 ? 1548 HOH A O     1 
HETATM 2806 O O     . HOH E 4 .   ? 32.29850  -24.61561 30.51167  1.000 19.22429 ? 1549 HOH A O     1 
HETATM 2807 O O     . HOH E 4 .   ? -10.98281 -19.97684 14.11639  1.000 42.13834 ? 1550 HOH A O     1 
HETATM 2808 O O     . HOH E 4 .   ? 5.75928   -19.86516 18.34257  1.000 14.86638 ? 1551 HOH A O     1 
HETATM 2809 O O     . HOH E 4 .   ? 4.09599   -34.53071 27.29698  1.000 20.82477 ? 1552 HOH A O     1 
HETATM 2810 O O     . HOH E 4 .   ? 8.98674   -41.71271 27.63005  1.000 43.58255 ? 1553 HOH A O     1 
HETATM 2811 O O     . HOH E 4 .   ? 8.46233   5.52893   5.23948   1.000 41.84133 ? 1554 HOH A O     1 
HETATM 2812 O O     . HOH E 4 .   ? 16.16612  -14.63237 29.09112  1.000 15.93007 ? 1555 HOH A O     1 
HETATM 2813 O O     . HOH E 4 .   ? 38.82143  -20.93861 25.88653  1.000 14.89549 ? 1556 HOH A O     1 
HETATM 2814 O O     . HOH E 4 .   ? 0.23358   -29.22987 17.40889  1.000 31.41614 ? 1557 HOH A O     1 
HETATM 2815 O O     . HOH E 4 .   ? 24.97033  -36.99552 19.23532  1.000 33.08403 ? 1558 HOH A O     1 
HETATM 2816 O O     . HOH E 4 .   ? 33.51765  -31.07180 19.37490  1.000 23.65000 ? 1559 HOH A O     1 
HETATM 2817 O O     . HOH E 4 .   ? -13.13731 -20.12852 20.57516  1.000 20.49252 ? 1560 HOH A O     1 
HETATM 2818 O O     . HOH E 4 .   ? 27.41513  -16.09762 22.77114  1.000 11.02848 ? 1561 HOH A O     1 
HETATM 2819 O O     . HOH E 4 .   ? -3.01140  -26.80314 20.57797  1.000 25.36097 ? 1562 HOH A O     1 
HETATM 2820 O O     . HOH E 4 .   ? 10.28445  0.69734   19.50019  1.000 37.38907 ? 1563 HOH A O     1 
HETATM 2821 O O     . HOH E 4 .   ? 19.04499  -29.57075 34.13358  1.000 13.28918 ? 1564 HOH A O     1 
HETATM 2822 O O     . HOH E 4 .   ? 36.82696  -21.75197 8.21930   1.000 30.45784 ? 1565 HOH A O     1 
HETATM 2823 O O     . HOH E 4 .   ? 25.16705  -2.23409  -12.17903 1.000 31.67056 ? 1566 HOH A O     1 
HETATM 2824 O O     . HOH E 4 .   ? 26.14864  -36.13294 12.44385  1.000 37.79484 ? 1567 HOH A O     1 
HETATM 2825 O O     . HOH E 4 .   ? 17.28944  -40.10494 24.41408  1.000 17.48778 ? 1568 HOH A O     1 
HETATM 2826 O O     . HOH E 4 .   ? 5.31616   -6.05549  -1.22549  1.000 34.21078 ? 1569 HOH A O     1 
HETATM 2827 O O     . HOH E 4 .   ? 26.71993  -24.31284 11.69650  1.000 12.33588 ? 1570 HOH A O     1 
HETATM 2828 O O     . HOH E 4 .   ? 7.42489   -27.89429 15.49601  1.000 18.64610 ? 1571 HOH A O     1 
HETATM 2829 O O     . HOH E 4 .   ? 24.36897  -33.08411 21.33966  1.000 13.77666 ? 1572 HOH A O     1 
HETATM 2830 O O     . HOH E 4 .   ? -2.35634  -18.67991 16.96665  1.000 31.11017 ? 1573 HOH A O     1 
HETATM 2831 O O     . HOH E 4 .   ? 21.19158  -10.58995 22.24437  1.000 14.21806 ? 1574 HOH A O     1 
HETATM 2832 O O     . HOH E 4 .   ? 4.87399   -14.00531 -8.84073  1.000 39.58705 ? 1575 HOH A O     1 
HETATM 2833 O O     . HOH E 4 .   ? 6.07717   -8.75367  -4.12163  1.000 32.71932 ? 1576 HOH A O     1 
HETATM 2834 O O     . HOH E 4 .   ? 39.98349  -23.02400 10.46924  1.000 37.86451 ? 1577 HOH A O     1 
HETATM 2835 O O     . HOH E 4 .   ? 25.33429  -35.96811 25.99856  1.000 33.47244 ? 1578 HOH A O     1 
HETATM 2836 O O     . HOH E 4 .   ? 15.85532  -6.16111  15.49230  1.000 17.77967 ? 1579 HOH A O     1 
HETATM 2837 O O     . HOH E 4 .   ? 23.96082  -28.64528 5.40450   1.000 29.48369 ? 1580 HOH A O     1 
HETATM 2838 O O     . HOH E 4 .   ? 15.58476  -31.49957 17.61063  1.000 23.33711 ? 1581 HOH A O     1 
HETATM 2839 O O     . HOH E 4 .   ? 28.63280  -25.43768 9.99945   1.000 14.88903 ? 1582 HOH A O     1 
HETATM 2840 O O     . HOH E 4 .   ? 20.92128  -25.04686 -1.52978  1.000 24.06911 ? 1583 HOH A O     1 
HETATM 2841 O O     . HOH E 4 .   ? 32.10778  -18.56312 -0.86209  1.000 19.83611 ? 1584 HOH A O     1 
HETATM 2842 O O     . HOH E 4 .   ? 24.57700  -7.47928  22.67615  1.000 24.31444 ? 1585 HOH A O     1 
HETATM 2843 O O     . HOH E 4 .   ? 26.50168  -36.07037 28.37151  1.000 37.72917 ? 1586 HOH A O     1 
HETATM 2844 O O     . HOH E 4 .   ? 3.66986   -34.48872 31.17869  1.000 28.38155 ? 1587 HOH A O     1 
HETATM 2845 O O     . HOH E 4 .   ? 25.53902  -12.77461 26.14828  1.000 13.66276 ? 1588 HOH A O     1 
HETATM 2846 O O     . HOH E 4 .   ? 6.02335   1.94633   22.55334  1.000 38.43594 ? 1589 HOH A O     1 
HETATM 2847 O O     . HOH E 4 .   ? 16.89346  -22.78624 12.15716  1.000 21.70535 ? 1590 HOH A O     1 
HETATM 2848 O O     . HOH E 4 .   ? 4.23891   -17.87351 34.52503  1.000 23.71865 ? 1591 HOH A O     1 
HETATM 2849 O O     . HOH E 4 .   ? 39.02402  -13.96279 7.05383   1.000 26.36079 ? 1592 HOH A O     1 
HETATM 2850 O O     . HOH E 4 .   ? 3.12477   -20.64490 9.45593   1.000 26.07792 ? 1593 HOH A O     1 
HETATM 2851 O O     . HOH E 4 .   ? 15.37030  -26.53251 39.32553  1.000 15.42750 ? 1594 HOH A O     1 
HETATM 2852 O O     . HOH E 4 .   ? 6.63518   -7.04116  26.54999  1.000 36.83118 ? 1595 HOH A O     1 
HETATM 2853 O O     . HOH E 4 .   ? 19.83250  -0.34087  9.74294   1.000 32.42340 ? 1596 HOH A O     1 
HETATM 2854 O O     . HOH E 4 .   ? 22.61150  -1.78156  3.84106   1.000 17.44174 ? 1597 HOH A O     1 
HETATM 2855 O O     . HOH E 4 .   ? 24.13149  -11.69491 17.01757  1.000 12.02830 ? 1598 HOH A O     1 
HETATM 2856 O O     . HOH E 4 .   ? 35.33862  -11.66506 0.80569   1.000 40.38312 ? 1599 HOH A O     1 
HETATM 2857 O O     . HOH E 4 .   ? 20.70592  -25.69747 2.98421   1.000 18.80612 ? 1600 HOH A O     1 
HETATM 2858 O O     . HOH E 4 .   ? 34.48226  -3.97942  9.32797   1.000 15.13590 ? 1601 HOH A O     1 
HETATM 2859 O O     . HOH E 4 .   ? 35.17850  -14.32211 12.99158  1.000 17.59078 ? 1602 HOH A O     1 
HETATM 2860 O O     . HOH E 4 .   ? 11.51673  -17.89899 -16.78535 1.000 41.20109 ? 1603 HOH A O     1 
HETATM 2861 O O     . HOH E 4 .   ? 14.15389  -33.73113 18.29080  1.000 27.10907 ? 1604 HOH A O     1 
HETATM 2862 O O     . HOH E 4 .   ? 13.37744  3.15124   2.62977   1.000 39.83643 ? 1605 HOH A O     1 
HETATM 2863 O O     . HOH E 4 .   ? 37.96813  -17.42766 23.04907  1.000 16.00630 ? 1606 HOH A O     1 
HETATM 2864 O O     . HOH E 4 .   ? 11.27386  3.44793   13.88765  1.000 40.52893 ? 1607 HOH A O     1 
HETATM 2865 O O     . HOH E 4 .   ? 23.72776  -29.83247 -6.51042  1.000 38.81808 ? 1608 HOH A O     1 
HETATM 2866 O O     . HOH E 4 .   ? 9.26295   0.72874   23.16393  1.000 41.39592 ? 1609 HOH A O     1 
HETATM 2867 O O     . HOH E 4 .   ? 32.35187  -13.24317 -0.54014  1.000 24.08805 ? 1610 HOH A O     1 
HETATM 2868 O O     . HOH E 4 .   ? 38.64894  -17.16367 0.94003   1.000 32.37854 ? 1611 HOH A O     1 
HETATM 2869 O O     . HOH E 4 .   ? 8.45559   -26.70609 33.48382  1.000 11.65868 ? 1612 HOH A O     1 
HETATM 2870 O O     . HOH E 4 .   ? 41.42146  -19.20561 11.50656  1.000 26.82155 ? 1613 HOH A O     1 
HETATM 2871 O O     . HOH E 4 .   ? 28.21468  0.53542   9.43133   1.000 15.50060 ? 1614 HOH A O     1 
HETATM 2872 O O     . HOH E 4 .   ? 25.90346  -24.28642 24.83007  1.000 11.84885 ? 1615 HOH A O     1 
HETATM 2873 O O     . HOH E 4 .   ? 29.37627  -30.01988 25.41516  1.000 15.81150 ? 1616 HOH A O     1 
HETATM 2874 O O     . HOH E 4 .   ? 3.02709   -5.06140  0.10534   1.000 38.56964 ? 1617 HOH A O     1 
HETATM 2875 O O     . HOH E 4 .   ? 0.95244   -24.58730 27.68385  1.000 19.84733 ? 1618 HOH A O     1 
HETATM 2876 O O     . HOH E 4 .   ? 23.24252  -16.11656 -9.21051  1.000 24.95564 ? 1619 HOH A O     1 
HETATM 2877 O O     . HOH E 4 .   ? 30.52228  -19.97507 17.89675  1.000 10.38466 ? 1620 HOH A O     1 
HETATM 2878 O O     . HOH E 4 .   ? 35.01308  -9.32490  10.35110  1.000 25.14189 ? 1621 HOH A O     1 
HETATM 2879 O O     . HOH E 4 .   ? 10.53091  -9.59614  30.44424  1.000 30.86517 ? 1622 HOH A O     1 
HETATM 2880 O O     . HOH E 4 .   ? 9.21311   -29.66394 28.81431  1.000 16.15422 ? 1623 HOH A O     1 
HETATM 2881 O O     . HOH E 4 .   ? 31.79406  -18.56932 5.89223   1.000 13.23488 ? 1624 HOH A O     1 
HETATM 2882 O O     . HOH E 4 .   ? 6.30885   0.32330   17.63189  1.000 26.06942 ? 1625 HOH A O     1 
HETATM 2883 O O     . HOH E 4 .   ? 18.47231  -18.51772 36.95715  1.000 29.58474 ? 1626 HOH A O     1 
HETATM 2884 O O     . HOH E 4 .   ? 14.80988  -8.21923  26.35677  1.000 27.78340 ? 1627 HOH A O     1 
HETATM 2885 O O     . HOH E 4 .   ? 16.731    -10.108   -21.298   1.000 20.86033 ? 1628 HOH A O     1 
HETATM 2886 O O     . HOH E 4 .   ? 29.14937  -34.31828 16.68150  1.000 28.13758 ? 1629 HOH A O     1 
HETATM 2887 O O     . HOH E 4 .   ? 11.91610  -18.90793 39.70892  1.000 23.30844 ? 1630 HOH A O     1 
HETATM 2888 O O     . HOH E 4 .   ? 19.397    -0.508    -9.102    1.000 35.43984 ? 1631 HOH A O     1 
HETATM 2889 O O     . HOH E 4 .   ? 28.07899  -27.70066 24.82503  1.000 11.65234 ? 1632 HOH A O     1 
HETATM 2890 O O     . HOH E 4 .   ? -10.93791 -25.55140 22.70614  1.000 28.20308 ? 1633 HOH A O     1 
HETATM 2891 O O     . HOH E 4 .   ? 30.52805  -29.17757 18.65063  1.000 17.39321 ? 1634 HOH A O     1 
HETATM 2892 O O     . HOH E 4 .   ? 10.87578  -22.67551 39.07279  1.000 16.23165 ? 1635 HOH A O     1 
HETATM 2893 O O     . HOH E 4 .   ? 14.64622  -7.23171  21.46818  1.000 15.83400 ? 1636 HOH A O     1 
HETATM 2894 O O     . HOH E 4 .   ? 22.51982  -19.44794 25.47394  1.000 11.77612 ? 1637 HOH A O     1 
HETATM 2895 O O     . HOH E 4 .   ? 18.59361  -27.02424 -9.72645  1.000 17.10658 ? 1638 HOH A O     1 
HETATM 2896 O O     . HOH E 4 .   ? 13.25476  1.55847   15.34011  1.000 36.84848 ? 1639 HOH A O     1 
HETATM 2897 O O     . HOH E 4 .   ? 1.01040   -33.02451 21.10421  1.000 22.49346 ? 1640 HOH A O     1 
HETATM 2898 O O     . HOH E 4 .   ? 7.77217   -24.07446 32.86176  1.000 11.93481 ? 1641 HOH A O     1 
HETATM 2899 O O     . HOH E 4 .   ? 19.47225  -22.73679 -14.36097 1.000 23.27713 ? 1642 HOH A O     1 
HETATM 2900 O O     . HOH E 4 .   ? 26.43897  -9.92473  -11.70679 1.000 25.62981 ? 1643 HOH A O     1 
HETATM 2901 O O     . HOH E 4 .   ? 15.75255  -36.29586 18.61250  1.000 23.16500 ? 1644 HOH A O     1 
HETATM 2902 O O     . HOH E 4 .   ? 12.92284  -27.52228 8.18315   1.000 38.75004 ? 1645 HOH A O     1 
HETATM 2903 O O     . HOH E 4 .   ? 34.67697  -26.01817 14.07554  1.000 28.17678 ? 1646 HOH A O     1 
HETATM 2904 O O     . HOH E 4 .   ? 35.24028  -15.32834 -1.15376  1.000 31.46609 ? 1647 HOH A O     1 
HETATM 2905 O O     . HOH E 4 .   ? 5.21971   -8.46450  -1.91797  1.000 33.93880 ? 1648 HOH A O     1 
HETATM 2906 O O     . HOH E 4 .   ? 15.01967  -35.49203 14.35082  1.000 30.26406 ? 1649 HOH A O     1 
HETATM 2907 O O     . HOH E 4 .   ? 28.91184  -27.51476 20.02294  1.000 12.41291 ? 1650 HOH A O     1 
HETATM 2908 O O     . HOH E 4 .   ? 37.72040  -3.90513  5.57508   1.000 35.19109 ? 1651 HOH A O     1 
HETATM 2909 O O     . HOH E 4 .   ? 29.08452  -20.27794 -3.42777  1.000 21.89805 ? 1652 HOH A O     1 
HETATM 2910 O O     . HOH E 4 .   ? 2.96866   -26.53847 16.30699  1.000 18.93413 ? 1653 HOH A O     1 
HETATM 2911 O O     . HOH E 4 .   ? 31.57911  -30.13483 26.84038  1.000 21.30554 ? 1654 HOH A O     1 
HETATM 2912 O O     . HOH E 4 .   ? 3.30749   -13.45747 19.68858  1.000 22.38727 ? 1655 HOH A O     1 
HETATM 2913 O O     . HOH E 4 .   ? -7.96824  -16.28767 14.49485  1.000 39.94807 ? 1656 HOH A O     1 
HETATM 2914 O O     . HOH E 4 .   ? 19.33824  -22.06501 14.65223  1.000 14.65278 ? 1657 HOH A O     1 
HETATM 2915 O O     . HOH E 4 .   ? 11.59565  -4.45340  20.64716  1.000 24.32815 ? 1658 HOH A O     1 
HETATM 2916 O O     . HOH E 4 .   ? 7.88071   -15.08081 10.93927  1.000 25.21208 ? 1659 HOH A O     1 
HETATM 2917 O O     . HOH E 4 .   ? 7.03413   -36.93546 22.35650  1.000 30.59895 ? 1660 HOH A O     1 
HETATM 2918 O O     . HOH E 4 .   ? 35.08864  -10.89390 12.50242  1.000 22.04202 ? 1661 HOH A O     1 
HETATM 2919 O O     . HOH E 4 .   ? 18.06896  -15.53129 -17.38005 1.000 38.87744 ? 1662 HOH A O     1 
HETATM 2920 O O     . HOH E 4 .   ? 5.27123   -8.12864  9.51991   1.000 35.81333 ? 1663 HOH A O     1 
HETATM 2921 O O     . HOH E 4 .   ? 14.67675  0.59835   13.32331  1.000 29.26767 ? 1664 HOH A O     1 
HETATM 2922 O O     . HOH E 4 .   ? -2.64306  -8.71073  14.98742  1.000 45.60322 ? 1665 HOH A O     1 
HETATM 2923 O O     . HOH E 4 .   ? 29.25949  -12.68920 -3.35122  1.000 22.20478 ? 1666 HOH A O     1 
HETATM 2924 O O     . HOH E 4 .   ? 4.76516   -10.68787 2.52294   1.000 31.55083 ? 1667 HOH A O     1 
HETATM 2925 O O     . HOH E 4 .   ? 34.18450  -17.75170 28.40667  1.000 19.35436 ? 1668 HOH A O     1 
HETATM 2926 O O     . HOH E 4 .   ? 35.69777  -22.86260 10.44931  1.000 24.80031 ? 1669 HOH A O     1 
HETATM 2927 O O     . HOH E 4 .   ? 12.31517  -1.10409  19.76473  1.000 41.74672 ? 1670 HOH A O     1 
HETATM 2928 O O     . HOH E 4 .   ? 23.57231  -0.65111  19.68022  1.000 30.85331 ? 1671 HOH A O     1 
HETATM 2929 O O     . HOH E 4 .   ? 7.06499   -33.40972 16.19637  1.000 37.63918 ? 1672 HOH A O     1 
HETATM 2930 O O     . HOH E 4 .   ? -5.37448  -20.56120 14.66152  1.000 34.23545 ? 1673 HOH A O     1 
HETATM 2931 O O     . HOH E 4 .   ? -16.01943 -16.53976 14.47220  1.000 21.88970 ? 1674 HOH A O     1 
HETATM 2932 O O     . HOH E 4 .   ? 1.40396   -21.47690 15.80658  1.000 26.74202 ? 1675 HOH A O     1 
HETATM 2933 O O     . HOH E 4 .   ? 34.14622  -14.18016 28.29884  1.000 26.58410 ? 1676 HOH A O     1 
HETATM 2934 O O     . HOH E 4 .   ? -11.46438 -22.80012 16.39107  1.000 26.72424 ? 1677 HOH A O     1 
HETATM 2935 O O     . HOH E 4 .   ? 26.41528  -24.87850 0.89282   1.000 27.17812 ? 1678 HOH A O     1 
HETATM 2936 O O     . HOH E 4 .   ? -0.91603  -30.61575 21.76370  1.000 28.34712 ? 1679 HOH A O     1 
HETATM 2937 O O     A HOH E 4 .   ? 20.33113  -39.10272 13.48126  0.604 28.40369 ? 1680 HOH A O     1 
HETATM 2938 O O     B HOH E 4 .   ? 21.96689  -39.48626 14.12046  0.396 28.32321 ? 1680 HOH A O     1 
HETATM 2939 O O     . HOH E 4 .   ? 2.80733   -18.47018 7.77488   1.000 20.89060 ? 1681 HOH A O     1 
HETATM 2940 O O     . HOH E 4 .   ? 32.56940  -28.94517 16.07358  1.000 25.05184 ? 1682 HOH A O     1 
HETATM 2941 O O     . HOH E 4 .   ? 28.23553  -29.76219 33.39712  1.000 36.97211 ? 1683 HOH A O     1 
HETATM 2942 O O     . HOH E 4 .   ? 6.93574   -17.55301 14.94265  1.000 22.02759 ? 1684 HOH A O     1 
HETATM 2943 O O     . HOH E 4 .   ? 28.50409  -10.21265 -9.67958  1.000 24.48197 ? 1685 HOH A O     1 
HETATM 2944 O O     . HOH E 4 .   ? 8.36186   -12.31009 16.73810  1.000 17.32763 ? 1686 HOH A O     1 
HETATM 2945 O O     . HOH E 4 .   ? -2.66850  -21.12483 14.16476  1.000 38.44726 ? 1687 HOH A O     1 
HETATM 2946 O O     . HOH E 4 .   ? 20.26046  -15.16811 31.53055  1.000 23.48700 ? 1688 HOH A O     1 
HETATM 2947 O O     . HOH E 4 .   ? 27.45521  -26.66181 22.25085  1.000 11.29459 ? 1689 HOH A O     1 
HETATM 2948 O O     . HOH E 4 .   ? 36.52573  -15.36177 15.66051  1.000 13.40367 ? 1690 HOH A O     1 
HETATM 2949 O O     . HOH E 4 .   ? 28.16750  -22.82843 -2.56507  1.000 27.92804 ? 1691 HOH A O     1 
HETATM 2950 O O     . HOH E 4 .   ? 31.20389  -9.61151  -0.69482  1.000 31.74408 ? 1692 HOH A O     1 
HETATM 2951 O O     . HOH E 4 .   ? 17.59746  -4.35080  21.34611  1.000 21.06024 ? 1693 HOH A O     1 
HETATM 2952 O O     . HOH E 4 .   ? 17.37797  1.23691   15.56003  1.000 37.96897 ? 1694 HOH A O     1 
HETATM 2953 O O     . HOH E 4 .   ? 30.87167  -21.06752 0.47804   1.000 21.76786 ? 1695 HOH A O     1 
HETATM 2954 O O     . HOH E 4 .   ? 31.90878  -21.16102 3.06056   1.000 18.85720 ? 1696 HOH A O     1 
HETATM 2955 O O     . HOH E 4 .   ? 8.408     -21.832   -11.726   1.000 29.49992 ? 1697 HOH A O     1 
HETATM 2956 O O     . HOH E 4 .   ? 19.43997  -26.59475 10.27735  1.000 17.80040 ? 1698 HOH A O     1 
HETATM 2957 O O     . HOH E 4 .   ? 30.02852  -16.71067 -0.76053  1.000 17.21843 ? 1699 HOH A O     1 
HETATM 2958 O O     . HOH E 4 .   ? 39.55805  -25.91438 19.27601  1.000 21.58488 ? 1700 HOH A O     1 
HETATM 2959 O O     . HOH E 4 .   ? 24.89805  -17.19031 22.13106  1.000 10.53990 ? 1701 HOH A O     1 
HETATM 2960 O O     . HOH E 4 .   ? -0.10950  -4.72558  1.80436   1.000 40.74401 ? 1702 HOH A O     1 
HETATM 2961 O O     . HOH E 4 .   ? 36.45651  -11.86851 26.99474  1.000 23.79601 ? 1703 HOH A O     1 
HETATM 2962 O O     . HOH E 4 .   ? 8.78103   -9.76051  15.70782  1.000 20.70857 ? 1704 HOH A O     1 
HETATM 2963 O O     . HOH E 4 .   ? 33.37380  -0.41987  1.45348   1.000 30.17122 ? 1705 HOH A O     1 
HETATM 2964 O O     . HOH E 4 .   ? 22.33750  -20.86944 16.21119  1.000 13.96810 ? 1706 HOH A O     1 
HETATM 2965 O O     . HOH E 4 .   ? -12.24808 -19.46270 26.43221  1.000 18.73426 ? 1707 HOH A O     1 
HETATM 2966 O O     . HOH E 4 .   ? 20.91152  -13.87972 27.42537  1.000 19.66330 ? 1708 HOH A O     1 
HETATM 2967 O O     . HOH E 4 .   ? -14.75704 -21.22034 17.46986  1.000 26.94112 ? 1709 HOH A O     1 
HETATM 2968 O O     . HOH E 4 .   ? 9.70091   -19.09259 -7.63124  1.000 33.94386 ? 1710 HOH A O     1 
HETATM 2969 O O     . HOH E 4 .   ? 38.77700  -32.22227 21.51040  1.000 31.27376 ? 1711 HOH A O     1 
HETATM 2970 O O     . HOH E 4 .   ? -0.98463  -11.69237 20.96484  1.000 35.14187 ? 1712 HOH A O     1 
HETATM 2971 O O     . HOH E 4 .   ? 4.95882   -16.42721 -5.17460  1.000 30.47989 ? 1713 HOH A O     1 
HETATM 2972 O O     . HOH E 4 .   ? 18.07886  -33.61311 11.48820  1.000 23.77790 ? 1714 HOH A O     1 
HETATM 2973 O O     . HOH E 4 .   ? 11.84588  -13.78104 -13.83513 1.000 26.20353 ? 1715 HOH A O     1 
HETATM 2974 O O     . HOH E 4 .   ? 10.48311  -5.73694  26.83627  1.000 36.15646 ? 1716 HOH A O     1 
HETATM 2975 O O     . HOH E 4 .   ? -9.71018  -11.28408 24.71767  1.000 38.18386 ? 1717 HOH A O     1 
HETATM 2976 O O     . HOH E 4 .   ? 1.03391   -12.42914 22.96265  1.000 27.97251 ? 1718 HOH A O     1 
HETATM 2977 O O     . HOH E 4 .   ? 2.10036   -7.61858  23.12776  1.000 36.99737 ? 1719 HOH A O     1 
HETATM 2978 O O     . HOH E 4 .   ? 7.68696   -6.29954  7.69170   1.000 23.75899 ? 1720 HOH A O     1 
HETATM 2979 O O     A HOH E 4 .   ? 6.90576   -35.72080 18.34029  0.712 22.11808 ? 1721 HOH A O     1 
HETATM 2980 O O     B HOH E 4 .   ? 7.15362   -36.59776 19.23339  0.288 21.11030 ? 1721 HOH A O     1 
HETATM 2981 O O     . HOH E 4 .   ? 10.71347  -20.42675 -16.76741 1.000 39.15616 ? 1722 HOH A O     1 
HETATM 2982 O O     . HOH E 4 .   ? 8.83432   -29.98623 31.56315  1.000 21.72801 ? 1723 HOH A O     1 
HETATM 2983 O O     . HOH E 4 .   ? 14.18624  -3.95514  -9.12913  1.000 25.92848 ? 1724 HOH A O     1 
HETATM 2984 O O     . HOH E 4 .   ? -0.43761  -15.34147 18.05586  1.000 23.88996 ? 1725 HOH A O     1 
HETATM 2985 O O     . HOH E 4 .   ? 25.11220  -7.46205  -12.52942 1.000 32.34237 ? 1726 HOH A O     1 
HETATM 2986 O O     . HOH E 4 .   ? 17.98007  -35.77614 31.95755  1.000 18.46159 ? 1727 HOH A O     1 
HETATM 2987 O O     . HOH E 4 .   ? 38.847    -23.652   26.134    1.000 10.85613 ? 1728 HOH A O     1 
HETATM 2988 O O     . HOH E 4 .   ? 11.03262  -16.67876 -13.82496 1.000 31.51543 ? 1729 HOH A O     1 
HETATM 2989 O O     . HOH E 4 .   ? 10.70199  -26.15911 8.81626   1.000 26.59375 ? 1730 HOH A O     1 
HETATM 2990 O O     . HOH E 4 .   ? 16.63402  -0.24629  8.11129   1.000 21.98243 ? 1731 HOH A O     1 
HETATM 2991 O O     . HOH E 4 .   ? 36.87469  -18.12665 28.99125  1.000 32.18791 ? 1732 HOH A O     1 
HETATM 2992 O O     . HOH E 4 .   ? 1.36146   -15.17121 2.97687   1.000 38.65002 ? 1733 HOH A O     1 
HETATM 2993 O O     . HOH E 4 .   ? 5.41349   -22.76078 32.14144  1.000 13.14853 ? 1734 HOH A O     1 
HETATM 2994 O O     . HOH E 4 .   ? 19.85269  -26.93524 -2.85717  1.000 29.40981 ? 1735 HOH A O     1 
HETATM 2995 O O     . HOH E 4 .   ? 39.31836  -18.63089 9.66518   1.000 23.50404 ? 1736 HOH A O     1 
HETATM 2996 O O     . HOH E 4 .   ? 40.38495  -16.56389 23.76130  1.000 38.19019 ? 1737 HOH A O     1 
HETATM 2997 O O     . HOH E 4 .   ? 20.81248  -23.48875 36.13819  1.000 32.95095 ? 1738 HOH A O     1 
HETATM 2998 O O     . HOH E 4 .   ? 28.40191  -32.19707 30.16334  1.000 31.61880 ? 1739 HOH A O     1 
HETATM 2999 O O     . HOH E 4 .   ? 27.07838  -21.09848 -11.35780 1.000 39.20300 ? 1740 HOH A O     1 
HETATM 3000 O O     . HOH E 4 .   ? 30.16565  -7.74393  19.46966  1.000 30.75046 ? 1741 HOH A O     1 
HETATM 3001 O O     . HOH E 4 .   ? 6.69236   -8.93045  14.14163  1.000 20.49237 ? 1742 HOH A O     1 
HETATM 3002 O O     . HOH E 4 .   ? -11.85205 -25.79956 17.37585  1.000 39.10790 ? 1743 HOH A O     1 
HETATM 3003 O O     . HOH E 4 .   ? 15.27731  -4.97380  19.95482  1.000 17.75600 ? 1744 HOH A O     1 
HETATM 3004 O O     . HOH E 4 .   ? 21.36929  -28.98620 32.81434  1.000 15.66811 ? 1745 HOH A O     1 
HETATM 3005 O O     . HOH E 4 .   ? 17.06513  -24.96704 1.51511   1.000 24.43975 ? 1746 HOH A O     1 
HETATM 3006 O O     . HOH E 4 .   ? 25.22489  -37.18516 16.55418  1.000 28.00248 ? 1747 HOH A O     1 
HETATM 3007 O O     . HOH E 4 .   ? 40.22857  -23.43787 18.15316  1.000 23.53685 ? 1748 HOH A O     1 
HETATM 3008 O O     . HOH E 4 .   ? 1.97863   -0.46306  14.98577  1.000 34.92023 ? 1749 HOH A O     1 
HETATM 3009 O O     . HOH E 4 .   ? -7.04712  -27.09443 20.71672  1.000 43.51671 ? 1750 HOH A O     1 
HETATM 3010 O O     . HOH E 4 .   ? 18.43429  -21.95613 36.79800  1.000 33.42734 ? 1751 HOH A O     1 
HETATM 3011 O O     . HOH E 4 .   ? 31.01225  -25.25168 12.18673  1.000 27.56644 ? 1752 HOH A O     1 
HETATM 3012 O O     . HOH E 4 .   ? 6.05137   -35.46661 28.68499  1.000 34.97524 ? 1753 HOH A O     1 
HETATM 3013 O O     . HOH E 4 .   ? 18.40559  -4.54843  -10.47508 1.000 27.93809 ? 1754 HOH A O     1 
HETATM 3014 O O     . HOH E 4 .   ? 13.95779  -14.63890 33.99373  1.000 19.37467 ? 1755 HOH A O     1 
HETATM 3015 O O     . HOH E 4 .   ? 5.41160   -25.77542 11.32821  1.000 39.12508 ? 1756 HOH A O     1 
HETATM 3016 O O     . HOH E 4 .   ? 39.30332  -8.89497  18.97606  1.000 43.86622 ? 1757 HOH A O     1 
HETATM 3017 O O     . HOH E 4 .   ? 38.38476  -21.40020 1.28692   1.000 40.32610 ? 1758 HOH A O     1 
HETATM 3018 O O     . HOH E 4 .   ? 32.72016  -13.04361 -5.66351  1.000 40.59178 ? 1759 HOH A O     1 
HETATM 3019 O O     . HOH E 4 .   ? 21.17169  0.47653   5.95524   1.000 38.20519 ? 1760 HOH A O     1 
HETATM 3020 O O     . HOH E 4 .   ? 19.95483  0.10245   12.61937  1.000 35.52027 ? 1761 HOH A O     1 
HETATM 3021 O O     . HOH E 4 .   ? 23.56039  -1.49797  6.48151   1.000 16.90154 ? 1762 HOH A O     1 
HETATM 3022 O O     . HOH E 4 .   ? 8.00685   -36.94585 27.91923  1.000 41.69760 ? 1763 HOH A O     1 
HETATM 3023 O O     . HOH E 4 .   ? 37.41112  -7.44604  5.88200   1.000 37.12557 ? 1764 HOH A O     1 
HETATM 3024 O O     . HOH E 4 .   ? 8.402     -31.647   15.463    1.000 34.76454 ? 1765 HOH A O     1 
HETATM 3025 O O     . HOH E 4 .   ? 11.29079  -24.97402 5.25576   1.000 23.85228 ? 1766 HOH A O     1 
HETATM 3026 O O     . HOH E 4 .   ? 19.98060  -40.53085 24.61087  1.000 31.27339 ? 1767 HOH A O     1 
HETATM 3027 O O     . HOH E 4 .   ? 22.31222  -16.84058 -12.26392 1.000 36.03524 ? 1768 HOH A O     1 
HETATM 3028 O O     . HOH E 4 .   ? 16.47196  -42.86777 23.75080  1.000 29.77170 ? 1769 HOH A O     1 
HETATM 3029 O O     . HOH E 4 .   ? 22.96132  -16.35276 33.40918  1.000 32.26531 ? 1770 HOH A O     1 
HETATM 3030 O O     . HOH E 4 .   ? 4.20040   -30.53128 17.06918  1.000 33.11238 ? 1771 HOH A O     1 
HETATM 3031 O O     . HOH E 4 .   ? 17.08723  -35.71128 12.37274  1.000 31.03461 ? 1772 HOH A O     1 
HETATM 3032 O O     . HOH E 4 .   ? 28.34039  -33.94565 25.70668  1.000 38.89832 ? 1773 HOH A O     1 
HETATM 3033 O O     . HOH E 4 .   ? -14.937   -23.881   20.183    1.000 28.26017 ? 1774 HOH A O     1 
HETATM 3034 O O     . HOH E 4 .   ? 4.41874   -22.34348 13.35626  1.000 32.22637 ? 1775 HOH A O     1 
HETATM 3035 O O     . HOH E 4 .   ? -12.85509 -16.98170 21.43439  1.000 31.03523 ? 1776 HOH A O     1 
HETATM 3036 O O     . HOH E 4 .   ? 33.74758  -7.76162  18.61677  1.000 34.40728 ? 1777 HOH A O     1 
HETATM 3037 O O     . HOH E 4 .   ? -5.93336  -15.91801 16.15082  1.000 33.42474 ? 1778 HOH A O     1 
HETATM 3038 O O     . HOH E 4 .   ? 3.63426   3.59869   16.63463  1.000 44.27817 ? 1779 HOH A O     1 
HETATM 3039 O O     . HOH E 4 .   ? 17.74561  -39.29153 28.82718  1.000 28.18370 ? 1780 HOH A O     1 
HETATM 3040 O O     . HOH E 4 .   ? 22.31014  -15.36643 29.76062  1.000 27.31340 ? 1781 HOH A O     1 
HETATM 3041 O O     . HOH E 4 .   ? 13.81927  -33.29387 13.90002  1.000 36.84537 ? 1782 HOH A O     1 
HETATM 3042 O O     . HOH E 4 .   ? 7.70705   -15.19872 13.57966  1.000 24.89194 ? 1783 HOH A O     1 
HETATM 3043 O O     . HOH E 4 .   ? 9.10776   -14.41040 33.35554  1.000 33.17261 ? 1784 HOH A O     1 
HETATM 3044 O O     . HOH E 4 .   ? 27.07586  -13.73862 30.26209  1.000 37.12177 ? 1785 HOH A O     1 
HETATM 3045 O O     . HOH E 4 .   ? 7.55458   -5.01794  -6.64063  1.000 45.34477 ? 1786 HOH A O     1 
HETATM 3046 O O     . HOH E 4 .   ? 27.14344  -6.06764  -5.06360  1.000 25.00053 ? 1787 HOH A O     1 
HETATM 3047 O O     . HOH E 4 .   ? 1.46698   -22.69486 29.70438  1.000 28.50910 ? 1788 HOH A O     1 
HETATM 3048 O O     . HOH E 4 .   ? 27.57030  -4.96324  -2.55086  1.000 35.73599 ? 1789 HOH A O     1 
HETATM 3049 O O     . HOH E 4 .   ? -0.668    -18.453   28.649    1.000 25.95913 ? 1790 HOH A O     1 
HETATM 3050 O O     . HOH E 4 .   ? 7.38215   2.72980   19.24765  1.000 43.30228 ? 1791 HOH A O     1 
HETATM 3051 O O     . HOH E 4 .   ? 34.32684  -35.81651 14.73549  1.000 37.63570 ? 1792 HOH A O     1 
HETATM 3052 O O     . HOH E 4 .   ? 26.27069  -5.76650  21.60189  1.000 30.68044 ? 1793 HOH A O     1 
HETATM 3053 O O     . HOH E 4 .   ? -0.54445  -36.34734 17.13984  1.000 41.29994 ? 1794 HOH A O     1 
HETATM 3054 O O     . HOH E 4 .   ? 4.18273   -6.66373  24.62277  1.000 40.14093 ? 1795 HOH A O     1 
HETATM 3055 O O     . HOH E 4 .   ? -2.74729  -30.18218 25.03809  1.000 38.03821 ? 1796 HOH A O     1 
HETATM 3056 O O     . HOH E 4 .   ? 5.00196   -15.32248 33.62636  1.000 35.03744 ? 1797 HOH A O     1 
HETATM 3057 O O     . HOH E 4 .   ? 39.11332  -27.43801 14.44049  1.000 41.05662 ? 1798 HOH A O     1 
HETATM 3058 O O     . HOH E 4 .   ? 24.75597  -3.73701  22.49555  1.000 41.70176 ? 1799 HOH A O     1 
HETATM 3059 O O     . HOH E 4 .   ? 22.68020  -12.67020 25.79581  1.000 21.98033 ? 1800 HOH A O     1 
HETATM 3060 O O     . HOH E 4 .   ? 10.87209  -4.49234  -17.03260 1.000 39.38240 ? 1801 HOH A O     1 
HETATM 3061 O O     . HOH E 4 .   ? 19.78387  -6.41943  21.64442  1.000 22.15119 ? 1802 HOH A O     1 
HETATM 3062 O O     . HOH E 4 .   ? 6.52869   -21.27056 2.15827   1.000 33.75345 ? 1803 HOH A O     1 
HETATM 3063 O O     . HOH E 4 .   ? 24.15030  -13.28513 -14.36976 1.000 42.49202 ? 1804 HOH A O     1 
HETATM 3064 O O     . HOH E 4 .   ? 12.17002  -4.24350  23.43553  1.000 31.71982 ? 1805 HOH A O     1 
HETATM 3065 O O     . HOH E 4 .   ? 25.29108  -18.14300 -8.79494  1.000 31.98487 ? 1806 HOH A O     1 
HETATM 3066 O O     . HOH E 4 .   ? 15.413    -28.149   12.073    1.000 28.25597 ? 1807 HOH A O     1 
HETATM 3067 O O     . HOH E 4 .   ? 20.61924  -25.00359 -13.20939 1.000 28.52569 ? 1808 HOH A O     1 
HETATM 3068 O O     . HOH E 4 .   ? 32.24413  -26.74225 13.48048  1.000 33.63738 ? 1809 HOH A O     1 
HETATM 3069 O O     . HOH E 4 .   ? 29.96568  -31.70297 8.36940   1.000 44.41563 ? 1810 HOH A O     1 
HETATM 3070 O O     . HOH E 4 .   ? 14.16782  1.66150   11.06361  1.000 41.46688 ? 1811 HOH A O     1 
HETATM 3071 O O     . HOH E 4 .   ? 23.00885  0.66182   2.88711   1.000 35.25596 ? 1812 HOH A O     1 
HETATM 3072 O O     . HOH E 4 .   ? 32.54808  -8.38629  20.83225  1.000 40.51265 ? 1813 HOH A O     1 
HETATM 3073 O O     . HOH E 4 .   ? 21.33063  -29.48198 -4.82605  1.000 38.76743 ? 1814 HOH A O     1 
HETATM 3074 O O     . HOH E 4 .   ? 36.99483  -7.86522  10.04072  1.000 39.40403 ? 1815 HOH A O     1 
HETATM 3075 O O     . HOH E 4 .   ? 24.00016  -38.83595 14.87898  1.000 42.68580 ? 1816 HOH A O     1 
HETATM 3076 O O     . HOH E 4 .   ? 15.57195  -4.94563  -10.93141 1.000 27.32522 ? 1817 HOH A O     1 
HETATM 3077 O O     . HOH E 4 .   ? 11.011    -33.545   33.959    1.000 39.51713 ? 1818 HOH A O     1 
HETATM 3078 O O     . HOH E 4 .   ? 8.86877   -39.09897 27.50338  1.000 43.57630 ? 1819 HOH A O     1 
HETATM 3079 O O     . HOH E 4 .   ? 12.77488  0.00276   -4.47341  1.000 37.29869 ? 1820 HOH A O     1 
HETATM 3080 O O     . HOH E 4 .   ? 6.55267   -19.48077 -1.56741  1.000 23.10954 ? 1821 HOH A O     1 
HETATM 3081 O O     . HOH E 4 .   ? 16.94466  2.27495   11.95478  1.000 47.13626 ? 1822 HOH A O     1 
HETATM 3082 O O     . HOH E 4 .   ? 31.99456  -35.74941 14.66093  1.000 39.67677 ? 1823 HOH A O     1 
HETATM 3083 O O     . HOH E 4 .   ? 16.687    -0.736    -9.019    1.000 38.38055 ? 1824 HOH A O     1 
HETATM 3084 O O     . HOH E 4 .   ? 41.80071  -14.84501 4.67655   1.000 40.35960 ? 1825 HOH A O     1 
HETATM 3085 O O     . HOH E 4 .   ? 2.64256   -16.60360 16.94420  1.000 29.33227 ? 1826 HOH A O     1 
HETATM 3086 O O     . HOH E 4 .   ? 6.18225   -4.60524  26.86977  1.000 40.99094 ? 1827 HOH A O     1 
HETATM 3087 O O     . HOH E 4 .   ? 37.47470  -10.43223 1.66978   1.000 45.32923 ? 1828 HOH A O     1 
HETATM 3088 O O     . HOH E 4 .   ? 30.598    -27.505   28.215    1.000 35.12174 ? 1829 HOH A O     1 
HETATM 3089 O O     . HOH E 4 .   ? 24.42037  -22.43841 33.58630  1.000 37.60937 ? 1830 HOH A O     1 
HETATM 3090 O O     . HOH E 4 .   ? 28.56624  -20.79205 -6.08165  1.000 34.68004 ? 1831 HOH A O     1 
HETATM 3091 O O     . HOH E 4 .   ? 30.80956  -14.68851 -2.28801  1.000 21.44092 ? 1832 HOH A O     1 
HETATM 3092 O O     . HOH E 4 .   ? 1.87848   -31.02823 17.44610  1.000 35.21057 ? 1833 HOH A O     1 
HETATM 3093 O O     . HOH E 4 .   ? -11.085   -14.902   27.909    1.000 33.91149 ? 1834 HOH A O     1 
HETATM 3094 O O     . HOH E 4 .   ? 11.32987  3.52736   5.00679   1.000 43.29521 ? 1835 HOH A O     1 
HETATM 3095 O O     . HOH E 4 .   ? 40.56378  -16.89588 7.91133   1.000 32.03568 ? 1836 HOH A O     1 
HETATM 3096 O O     . HOH E 4 .   ? 22.48744  -26.48653 0.72539   1.000 32.79140 ? 1837 HOH A O     1 
HETATM 3097 O O     . HOH E 4 .   ? 20.388    -12.716   -18.763   1.000 40.34818 ? 1838 HOH A O     1 
HETATM 3098 O O     . HOH E 4 .   ? -13.60423 -17.89356 24.77674  1.000 32.88101 ? 1839 HOH A O     1 
HETATM 3099 O O     . HOH E 4 .   ? 27.38639  -22.57033 35.00678  1.000 38.85725 ? 1840 HOH A O     1 
HETATM 3100 O O     . HOH E 4 .   ? 16.80789  -25.53580 -1.53967  1.000 34.38225 ? 1841 HOH A O     1 
HETATM 3101 O O     . HOH E 4 .   ? 38.389    -5.871    0.063     1.000 35.14392 ? 1842 HOH A O     1 
HETATM 3102 O O     . HOH E 4 .   ? 30.15272  -9.64764  -6.08773  1.000 40.52200 ? 1843 HOH A O     1 
HETATM 3103 O O     . HOH E 4 .   ? 33.172    -33.484   24.950    1.000 35.40328 ? 1844 HOH A O     1 
HETATM 3104 O O     . HOH E 4 .   ? 28.13147  -18.73940 -8.08260  1.000 38.63784 ? 1845 HOH A O     1 
HETATM 3105 O O     . HOH E 4 .   ? 38.82319  -19.49337 28.58794  1.000 26.16661 ? 1846 HOH A O     1 
HETATM 3106 O O     . HOH E 4 .   ? 20.58878  -18.10598 -14.39359 1.000 42.60614 ? 1847 HOH A O     1 
HETATM 3107 O O     . HOH E 4 .   ? 19.07860  -10.58403 25.25982  1.000 42.10249 ? 1848 HOH A O     1 
HETATM 3108 O O     . HOH E 4 .   ? 11.32693  -15.02963 34.77049  1.000 25.15751 ? 1849 HOH A O     1 
HETATM 3109 O O     . HOH E 4 .   ? 19.23242  -28.62911 -7.47925  1.000 26.08797 ? 1850 HOH A O     1 
HETATM 3110 O O     . HOH E 4 .   ? 22.60551  -39.54865 25.57377  1.000 46.33538 ? 1851 HOH A O     1 
HETATM 3111 O O     . HOH E 4 .   ? 19.32263  -16.33459 -15.31569 1.000 39.81912 ? 1852 HOH A O     1 
HETATM 3112 O O     . HOH E 4 .   ? 28.73865  -27.14820 7.81723   1.000 27.66843 ? 1853 HOH A O     1 
HETATM 3113 O O     . HOH E 4 .   ? 39.04336  -20.73477 8.35893   1.000 31.79482 ? 1854 HOH A O     1 
HETATM 3114 O O     . HOH E 4 .   ? 43.267    -22.046   14.840    1.000 42.47708 ? 1855 HOH A O     1 
HETATM 3115 O O     . HOH E 4 .   ? 18.77251  -37.78538 30.67982  1.000 39.60458 ? 1856 HOH A O     1 
HETATM 3116 O O     . HOH E 4 .   ? 31.29629  -25.96024 10.21191  1.000 35.49534 ? 1857 HOH A O     1 
HETATM 3117 O O     . HOH E 4 .   ? 26.75312  -34.65454 21.27287  1.000 25.90657 ? 1858 HOH A O     1 
HETATM 3118 O O     . HOH E 4 .   ? 39.76432  -27.68267 16.63003  1.000 43.59872 ? 1859 HOH A O     1 
HETATM 3119 O O     . HOH E 4 .   ? 22.01497  -6.10519  23.25389  1.000 35.19013 ? 1860 HOH A O     1 
HETATM 3120 O O     . HOH E 4 .   ? 27.20990  -26.22275 5.62773   1.000 32.37828 ? 1861 HOH A O     1 
HETATM 3121 O O     . HOH E 4 .   ? 1.03697   -19.58100 5.68311   1.000 35.14244 ? 1862 HOH A O     1 
HETATM 3122 O O     . HOH E 4 .   ? 2.15605   -23.07328 14.04112  1.000 43.99997 ? 1863 HOH A O     1 
HETATM 3123 O O     . HOH E 4 .   ? -15.37010 -17.21616 20.70225  1.000 35.61423 ? 1864 HOH A O     1 
HETATM 3124 O O     . HOH E 4 .   ? -3.76736  -27.97960 17.82597  1.000 40.93691 ? 1865 HOH A O     1 
HETATM 3125 O O     . HOH E 4 .   ? 23.00387  -36.41282 32.16983  1.000 41.28227 ? 1866 HOH A O     1 
HETATM 3126 O O     . HOH E 4 .   ? 34.62213  -33.86087 19.79580  1.000 45.43124 ? 1867 HOH A O     1 
HETATM 3127 O O     . HOH E 4 .   ? 26.216    0.630     3.478     1.000 29.92213 ? 1868 HOH A O     1 
HETATM 3128 O O     . HOH E 4 .   ? 6.02759   -16.16117 -7.67114  1.000 36.27333 ? 1869 HOH A O     1 
HETATM 3129 O O     . HOH E 4 .   ? -11.68008 -10.85041 25.35623  1.000 42.36733 ? 1870 HOH A O     1 
HETATM 3130 O O     . HOH E 4 .   ? 24.94804  -26.28973 4.24189   1.000 35.24820 ? 1871 HOH A O     1 
HETATM 3131 O O     . HOH E 4 .   ? 39.53620  -7.53471  3.14019   1.000 42.67591 ? 1872 HOH A O     1 
HETATM 3132 O O     . HOH E 4 .   ? 5.19984   -19.85452 14.93723  1.000 38.02831 ? 1873 HOH A O     1 
HETATM 3133 O O     A HOH E 4 .   ? 15.93955  -14.39462 35.71646  0.489 22.56426 ? 1874 HOH A O     1 
HETATM 3134 O O     B HOH E 4 .   ? 17.34149  -15.45000 36.07917  0.511 26.86641 ? 1874 HOH A O     1 
HETATM 3135 O O     . HOH E 4 .   ? 1.193     -18.594   33.817    1.000 41.77582 ? 1875 HOH A O     1 
HETATM 3136 O O     . HOH E 4 .   ? 22.84099  -21.30584 35.38784  1.000 40.65445 ? 1876 HOH A O     1 
HETATM 3137 O O     . HOH E 4 .   ? 6.64993   -13.63305 14.95360  1.000 32.07519 ? 1877 HOH A O     1 
HETATM 3138 O O     . HOH E 4 .   ? 2.036     -26.982   28.890    1.000 20.06091 ? 1878 HOH A O     1 
HETATM 3139 O O     . HOH E 4 .   ? 31.07706  -31.55924 23.44085  1.000 32.82995 ? 1879 HOH A O     1 
HETATM 3140 O O     . HOH E 4 .   ? 24.74031  -38.39058 25.27640  1.000 41.43435 ? 1880 HOH A O     1 
HETATM 3141 O O     . HOH E 4 .   ? 1.74475   -13.55040 0.24097   1.000 39.49937 ? 1881 HOH A O     1 
HETATM 3142 O O     . HOH E 4 .   ? 4.65577   -28.75953 15.72157  1.000 26.65628 ? 1882 HOH A O     1 
HETATM 3143 O O     . HOH E 4 .   ? 24.71587  -26.76785 1.49069   1.000 35.59833 ? 1883 HOH A O     1 
HETATM 3144 O O     . HOH E 4 .   ? 1.58211   -25.89319 14.08724  1.000 30.98636 ? 1884 HOH A O     1 
HETATM 3145 O O     . HOH E 4 .   ? 31.16907  -7.12726  -1.13944  1.000 44.69118 ? 1885 HOH A O     1 
HETATM 3146 O O     . HOH E 4 .   ? 40.470    -19.048   24.605    1.000 25.87775 ? 1886 HOH A O     1 
HETATM 3147 O O     . HOH E 4 .   ? -0.01093  -17.31803 16.04559  1.000 39.43703 ? 1887 HOH A O     1 
HETATM 3148 O O     . HOH E 4 .   ? 3.68535   -19.45244 16.65384  1.000 32.80217 ? 1888 HOH A O     1 
HETATM 3149 O O     . HOH E 4 .   ? 19.30249  -27.39857 -12.36545 1.000 27.39443 ? 1889 HOH A O     1 
HETATM 3150 O O     . HOH E 4 .   ? 18.70722  2.84167   5.27571   1.000 45.47106 ? 1890 HOH A O     1 
HETATM 3151 O O     . HOH E 4 .   ? 32.397    -27.324   29.845    1.000 26.73567 ? 1891 HOH A O     1 
HETATM 3152 O O     . HOH E 4 .   ? -16.724   -22.105   19.339    1.000 28.25401 ? 1892 HOH A O     1 
HETATM 3153 O O     . HOH E 4 .   ? 15.66589  -6.73499  24.10882  1.000 27.46901 ? 1893 HOH A O     1 
HETATM 3154 O O     . HOH E 4 .   ? 6.63556   -10.78387 5.38473   1.000 28.59748 ? 1894 HOH A O     1 
HETATM 3155 O O     . HOH E 4 .   ? 31.90234  -19.57192 -3.26634  1.000 32.85412 ? 1895 HOH A O     1 
HETATM 3156 O O     . HOH E 4 .   ? 27.15066  -3.40509  -6.59282  1.000 37.36057 ? 1896 HOH A O     1 
HETATM 3157 O O     . HOH E 4 .   ? 20.60214  0.30061   19.60170  1.000 42.10320 ? 1897 HOH A O     1 
HETATM 3158 O O     . HOH E 4 .   ? 41.37012  -27.19441 20.75259  1.000 29.79507 ? 1898 HOH A O     1 
HETATM 3159 O O     . HOH E 4 .   ? 2.48796   -10.23170 13.51394  1.000 41.71557 ? 1899 HOH A O     1 
HETATM 3160 O O     . HOH E 4 .   ? -15.763   -20.470   21.143    1.000 31.80649 ? 1900 HOH A O     1 
HETATM 3161 O O     . HOH E 4 .   ? 14.11615  -2.49217  20.19281  1.000 31.13946 ? 1901 HOH A O     1 
HETATM 3162 O O     . HOH E 4 .   ? 2.10050   -6.58846  -4.71177  1.000 44.53944 ? 1902 HOH A O     1 
HETATM 3163 O O     . HOH E 4 .   ? -8.835    -35.100   25.490    1.000 45.63096 ? 1903 HOH A O     1 
HETATM 3164 O O     . HOH E 4 .   ? 8.969     -28.114   8.730     1.000 32.85415 ? 1904 HOH A O     1 
HETATM 3165 O O     . HOH E 4 .   ? 26.74454  -10.35793 26.72397  1.000 33.28408 ? 1905 HOH A O     1 
HETATM 3166 O O     . HOH E 4 .   ? -19.491   -8.918    16.823    1.000 35.86170 ? 1906 HOH A O     1 
HETATM 3167 O O     . HOH E 4 .   ? 34.92234  -33.54758 22.73698  1.000 39.94566 ? 1907 HOH A O     1 
HETATM 3168 O O     . HOH E 4 .   ? 31.41074  -10.80047 -7.97974  1.000 41.03284 ? 1908 HOH A O     1 
HETATM 3169 O O     . HOH E 4 .   ? 16.90090  -24.58097 40.23107  1.000 35.79723 ? 1909 HOH A O     1 
HETATM 3170 O O     . HOH E 4 .   ? 4.34110   -9.73668  15.54129  1.000 31.33485 ? 1910 HOH A O     1 
HETATM 3171 O O     . HOH E 4 .   ? 25.083    -8.028    -15.239   1.000 33.69971 ? 1911 HOH A O     1 
HETATM 3172 O O     . HOH E 4 .   ? 35.003    -2.399    -0.422    1.000 31.97973 ? 1912 HOH A O     1 
HETATM 3173 O O     . HOH E 4 .   ? 20.42457  -14.71803 34.25050  1.000 44.57256 ? 1913 HOH A O     1 
HETATM 3174 O O     . HOH E 4 .   ? 13.979    -9.584    -21.954   1.000 36.96609 ? 1914 HOH A O     1 
HETATM 3175 O O     . HOH E 4 .   ? 29.24471  -7.14432  -6.16698  1.000 32.02937 ? 1915 HOH A O     1 
HETATM 3176 O O     . HOH E 4 .   ? 12.30311  -34.33249 16.68257  1.000 28.95597 ? 1916 HOH A O     1 
HETATM 3177 O O     . HOH E 4 .   ? 40.52349  -20.68883 5.62897   1.000 42.38279 ? 1917 HOH A O     1 
HETATM 3178 O O     . HOH E 4 .   ? 31.10602  -11.01184 -4.14661  1.000 37.21105 ? 1918 HOH A O     1 
HETATM 3179 O O     . HOH E 4 .   ? 1.77698   -20.30285 11.77272  1.000 35.20647 ? 1919 HOH A O     1 
HETATM 3180 O O     . HOH E 4 .   ? 3.84259   2.81631   23.94030  1.000 42.34398 ? 1920 HOH A O     1 
HETATM 3181 O O     . HOH E 4 .   ? 43.803    -16.236   11.844    1.000 40.83006 ? 1921 HOH A O     1 
HETATM 3182 O O     . HOH E 4 .   ? 25.815    -0.060    6.140     1.000 18.57940 ? 1922 HOH A O     1 
HETATM 3183 O O     . HOH E 4 .   ? 17.37209  -16.90894 39.07680  1.000 41.37833 ? 1923 HOH A O     1 
HETATM 3184 O O     . HOH E 4 .   ? 30.70560  -31.40043 20.27517  1.000 29.62996 ? 1924 HOH A O     1 
HETATM 3185 O O     . HOH E 4 .   ? 39.913    -4.771    4.196     1.000 29.04074 ? 1925 HOH A O     1 
HETATM 3186 O O     . HOH E 4 .   ? 29.28181  -33.34487 19.30472  1.000 40.33812 ? 1926 HOH A O     1 
HETATM 3187 O O     . HOH E 4 .   ? 29.20501  -7.68441  -10.62486 1.000 29.32863 ? 1927 HOH A O     1 
HETATM 3188 O O     . HOH E 4 .   ? 13.17665  -32.17792 38.85299  1.000 35.16523 ? 1928 HOH A O     1 
HETATM 3189 O O     . HOH E 4 .   ? 12.48844  -16.13464 39.80459  1.000 39.69304 ? 1929 HOH A O     1 
HETATM 3190 O O     . HOH E 4 .   ? 7.80174   -29.65710 13.36837  1.000 36.14673 ? 1930 HOH A O     1 
HETATM 3191 O O     . HOH E 4 .   ? 25.39751  -31.08142 5.47504   1.000 43.19703 ? 1931 HOH A O     1 
HETATM 3192 O O     . HOH E 4 .   ? 27.15803  -31.78815 7.68337   1.000 46.01566 ? 1932 HOH A O     1 
HETATM 3193 O O     . HOH E 4 .   ? 19.09319  -8.55691  23.44163  1.000 40.99549 ? 1933 HOH A O     1 
HETATM 3194 O O     . HOH E 4 .   ? 32.33775  -12.54897 29.22903  1.000 40.81870 ? 1934 HOH A O     1 
HETATM 3195 O O     . HOH E 4 .   ? 6.86444   -23.61491 2.93143   1.000 45.38049 ? 1935 HOH A O     1 
HETATM 3196 O O     . HOH E 4 .   ? 28.50570  -30.02403 7.89718   1.000 42.62537 ? 1936 HOH A O     1 
HETATM 3197 O O     . HOH E 4 .   ? 45.534    -18.214   10.908    1.000 45.07571 ? 1937 HOH A O     1 
# 
