data_9L6B
# 
_entry.id   9L6B 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9L6B         pdb_00009l6b 10.2210/pdb9l6b/pdb 
WWPDB D_1300054976 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-29 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9L6B 
_pdbx_database_status.recvd_initial_deposition_date   2024-12-24 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              wangweiwei_fly@126.com 
_pdbx_contact_author.name_first         weiwei 
_pdbx_contact_author.name_last          Wang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-9252-819X 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Yuan, X.L.' 1 0009-0001-4399-3255 
'Wang, W.W.' 2 0000-0002-9252-819X 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'A ROS-Sensing Transcription Factor Promotes RpoS Accumulation to Resist Oxidative Stress' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Yuan, X.L.' 1 0009-0001-4399-3255 
primary 'Wang, W.W.' 2 0000-0002-9252-819X 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'UPF0225 protein YchJ -A' 6634.627 1  ? ? ? ? 
2 polymer man 'UPF0225 protein YchJ -B' 6847.577 1  ? ? ? ? 
3 polymer man 'UPF0225 protein YchJ -C' 3641.189 1  ? ? ? ? 
4 water   nat water                     18.015   81 ? ? ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no MSQPCPCGSADEYSLCCGRIVSGERVAPDPSHLMRSRYCAFVMKDADYLIKSWHPTCNAA 
MSQPCPCGSADEYSLCCGRIVSGERVAPDPSHLMRSRYCAFVMKDADYLIKSWHPTCNAA A ? 
2 'polypeptide(L)' no no AFRDDIIAGFANTRWLGLTIFEHTWSEAENTGYVSFIARFSEQGKNGAIIERSRFIKENG 
AFRDDIIAGFANTRWLGLTIFEHTWSEAENTGYVSFIARFSEQGKNGAIIERSRFIKENG B ? 
3 'polypeptide(L)' no no QWYYIDGTRPQLGRNDPCPCGSGKKFKKCCGQ                             QWYYIDGTRPQLGRNDPCPCGSGKKFKKCCGQ C ? 
# 
_pdbx_entity_nonpoly.entity_id   4 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1  MET n 
1 2  SER n 
1 3  GLN n 
1 4  PRO n 
1 5  CYS n 
1 6  PRO n 
1 7  CYS n 
1 8  GLY n 
1 9  SER n 
1 10 ALA n 
1 11 ASP n 
1 12 GLU n 
1 13 TYR n 
1 14 SER n 
1 15 LEU n 
1 16 CYS n 
1 17 CYS n 
1 18 GLY n 
1 19 ARG n 
1 20 ILE n 
1 21 VAL n 
1 22 SER n 
1 23 GLY n 
1 24 GLU n 
1 25 ARG n 
1 26 VAL n 
1 27 ALA n 
1 28 PRO n 
1 29 ASP n 
1 30 PRO n 
1 31 SER n 
1 32 HIS n 
1 33 LEU n 
1 34 MET n 
1 35 ARG n 
1 36 SER n 
1 37 ARG n 
1 38 TYR n 
1 39 CYS n 
1 40 ALA n 
1 41 PHE n 
1 42 VAL n 
1 43 MET n 
1 44 LYS n 
1 45 ASP n 
1 46 ALA n 
1 47 ASP n 
1 48 TYR n 
1 49 LEU n 
1 50 ILE n 
1 51 LYS n 
1 52 SER n 
1 53 TRP n 
1 54 HIS n 
1 55 PRO n 
1 56 THR n 
1 57 CYS n 
1 58 ASN n 
1 59 ALA n 
1 60 ALA n 
2 1  ALA n 
2 2  PHE n 
2 3  ARG n 
2 4  ASP n 
2 5  ASP n 
2 6  ILE n 
2 7  ILE n 
2 8  ALA n 
2 9  GLY n 
2 10 PHE n 
2 11 ALA n 
2 12 ASN n 
2 13 THR n 
2 14 ARG n 
2 15 TRP n 
2 16 LEU n 
2 17 GLY n 
2 18 LEU n 
2 19 THR n 
2 20 ILE n 
2 21 PHE n 
2 22 GLU n 
2 23 HIS n 
2 24 THR n 
2 25 TRP n 
2 26 SER n 
2 27 GLU n 
2 28 ALA n 
2 29 GLU n 
2 30 ASN n 
2 31 THR n 
2 32 GLY n 
2 33 TYR n 
2 34 VAL n 
2 35 SER n 
2 36 PHE n 
2 37 ILE n 
2 38 ALA n 
2 39 ARG n 
2 40 PHE n 
2 41 SER n 
2 42 GLU n 
2 43 GLN n 
2 44 GLY n 
2 45 LYS n 
2 46 ASN n 
2 47 GLY n 
2 48 ALA n 
2 49 ILE n 
2 50 ILE n 
2 51 GLU n 
2 52 ARG n 
2 53 SER n 
2 54 ARG n 
2 55 PHE n 
2 56 ILE n 
2 57 LYS n 
2 58 GLU n 
2 59 ASN n 
2 60 GLY n 
3 1  GLN n 
3 2  TRP n 
3 3  TYR n 
3 4  TYR n 
3 5  ILE n 
3 6  ASP n 
3 7  GLY n 
3 8  THR n 
3 9  ARG n 
3 10 PRO n 
3 11 GLN n 
3 12 LEU n 
3 13 GLY n 
3 14 ARG n 
3 15 ASN n 
3 16 ASP n 
3 17 PRO n 
3 18 CYS n 
3 19 PRO n 
3 20 CYS n 
3 21 GLY n 
3 22 SER n 
3 23 GLY n 
3 24 LYS n 
3 25 LYS n 
3 26 PHE n 
3 27 LYS n 
3 28 LYS n 
3 29 CYS n 
3 30 CYS n 
3 31 GLY n 
3 32 GLN n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 60 ? ? 'ychJ, STM14_2121' ? ? ? ? ? ? 
'Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S' 588858 ? ? ? ? ? ? ? ? 'Escherichia coli BL21(DE3)' 469008 ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 60 ? ? 'ychJ, STM14_2121' ? ? ? ? ? ? 
'Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S' 588858 ? ? ? ? ? ? ? ? 'Escherichia coli BL21(DE3)' 469008 ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample 'Biological sequence' 1 32 ? ? 'ychJ, STM14_2121' ? ? ? ? ? ? 
'Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S' 588858 ? ? ? ? ? ? ? ? 'Escherichia coli BL21(DE3)' 469008 ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1  MET 1  1   1   MET MET A . n 
A 1 2  SER 2  2   2   SER SER A . n 
A 1 3  GLN 3  3   3   GLN GLN A . n 
A 1 4  PRO 4  4   4   PRO PRO A . n 
A 1 5  CYS 5  5   5   CYS CYS A . n 
A 1 6  PRO 6  6   6   PRO PRO A . n 
A 1 7  CYS 7  7   7   CYS CYS A . n 
A 1 8  GLY 8  8   8   GLY GLY A . n 
A 1 9  SER 9  9   9   SER SER A . n 
A 1 10 ALA 10 10  10  ALA ALA A . n 
A 1 11 ASP 11 11  11  ASP ASP A . n 
A 1 12 GLU 12 12  12  GLU GLU A . n 
A 1 13 TYR 13 13  13  TYR TYR A . n 
A 1 14 SER 14 14  14  SER SER A . n 
A 1 15 LEU 15 15  15  LEU LEU A . n 
A 1 16 CYS 16 16  16  CYS CYS A . n 
A 1 17 CYS 17 17  17  CYS CYS A . n 
A 1 18 GLY 18 18  18  GLY GLY A . n 
A 1 19 ARG 19 19  19  ARG ARG A . n 
A 1 20 ILE 20 20  20  ILE ILE A . n 
A 1 21 VAL 21 21  21  VAL VAL A . n 
A 1 22 SER 22 22  22  SER SER A . n 
A 1 23 GLY 23 23  23  GLY GLY A . n 
A 1 24 GLU 24 24  24  GLU GLU A . n 
A 1 25 ARG 25 25  25  ARG ARG A . n 
A 1 26 VAL 26 26  26  VAL VAL A . n 
A 1 27 ALA 27 27  27  ALA ALA A . n 
A 1 28 PRO 28 28  28  PRO PRO A . n 
A 1 29 ASP 29 29  29  ASP ASP A . n 
A 1 30 PRO 30 30  30  PRO PRO A . n 
A 1 31 SER 31 31  31  SER SER A . n 
A 1 32 HIS 32 32  32  HIS HIS A . n 
A 1 33 LEU 33 33  33  LEU LEU A . n 
A 1 34 MET 34 34  34  MET MET A . n 
A 1 35 ARG 35 35  35  ARG ARG A . n 
A 1 36 SER 36 36  36  SER SER A . n 
A 1 37 ARG 37 37  37  ARG ARG A . n 
A 1 38 TYR 38 38  38  TYR TYR A . n 
A 1 39 CYS 39 39  39  CYS CYS A . n 
A 1 40 ALA 40 40  40  ALA ALA A . n 
A 1 41 PHE 41 41  41  PHE PHE A . n 
A 1 42 VAL 42 42  42  VAL VAL A . n 
A 1 43 MET 43 43  43  MET MET A . n 
A 1 44 LYS 44 44  44  LYS LYS A . n 
A 1 45 ASP 45 45  45  ASP ASP A . n 
A 1 46 ALA 46 46  46  ALA ALA A . n 
A 1 47 ASP 47 47  47  ASP ASP A . n 
A 1 48 TYR 48 48  48  TYR TYR A . n 
A 1 49 LEU 49 49  49  LEU LEU A . n 
A 1 50 ILE 50 50  50  ILE ILE A . n 
A 1 51 LYS 51 51  51  LYS LYS A . n 
A 1 52 SER 52 52  52  SER SER A . n 
A 1 53 TRP 53 53  53  TRP TRP A . n 
A 1 54 HIS 54 54  54  HIS HIS A . n 
A 1 55 PRO 55 55  55  PRO PRO A . n 
A 1 56 THR 56 56  56  THR THR A . n 
A 1 57 CYS 57 57  57  CYS CYS A . n 
A 1 58 ASN 58 58  58  ASN ASN A . n 
A 1 59 ALA 59 59  59  ALA ALA A . n 
A 1 60 ALA 60 60  60  ALA ALA A . n 
B 2 1  ALA 1  61  61  ALA ALA B . n 
B 2 2  PHE 2  62  62  PHE PHE B . n 
B 2 3  ARG 3  63  63  ARG ARG B . n 
B 2 4  ASP 4  64  64  ASP ASP B . n 
B 2 5  ASP 5  65  65  ASP ASP B . n 
B 2 6  ILE 6  66  66  ILE ILE B . n 
B 2 7  ILE 7  67  67  ILE ILE B . n 
B 2 8  ALA 8  68  68  ALA ALA B . n 
B 2 9  GLY 9  69  69  GLY GLY B . n 
B 2 10 PHE 10 70  70  PHE PHE B . n 
B 2 11 ALA 11 71  71  ALA ALA B . n 
B 2 12 ASN 12 72  72  ASN ASN B . n 
B 2 13 THR 13 73  73  THR THR B . n 
B 2 14 ARG 14 74  74  ARG ARG B . n 
B 2 15 TRP 15 75  75  TRP TRP B . n 
B 2 16 LEU 16 76  76  LEU LEU B . n 
B 2 17 GLY 17 77  77  GLY GLY B . n 
B 2 18 LEU 18 78  78  LEU LEU B . n 
B 2 19 THR 19 79  79  THR THR B . n 
B 2 20 ILE 20 80  80  ILE ILE B . n 
B 2 21 PHE 21 81  81  PHE PHE B . n 
B 2 22 GLU 22 82  82  GLU GLU B . n 
B 2 23 HIS 23 83  83  HIS HIS B . n 
B 2 24 THR 24 84  84  THR THR B . n 
B 2 25 TRP 25 85  85  TRP TRP B . n 
B 2 26 SER 26 86  86  SER SER B . n 
B 2 27 GLU 27 87  87  GLU GLU B . n 
B 2 28 ALA 28 88  88  ALA ALA B . n 
B 2 29 GLU 29 89  89  GLU GLU B . n 
B 2 30 ASN 30 90  90  ASN ASN B . n 
B 2 31 THR 31 91  91  THR THR B . n 
B 2 32 GLY 32 92  92  GLY GLY B . n 
B 2 33 TYR 33 93  93  TYR TYR B . n 
B 2 34 VAL 34 94  94  VAL VAL B . n 
B 2 35 SER 35 95  95  SER SER B . n 
B 2 36 PHE 36 96  96  PHE PHE B . n 
B 2 37 ILE 37 97  97  ILE ILE B . n 
B 2 38 ALA 38 98  98  ALA ALA B . n 
B 2 39 ARG 39 99  99  ARG ARG B . n 
B 2 40 PHE 40 100 100 PHE PHE B . n 
B 2 41 SER 41 101 101 SER SER B . n 
B 2 42 GLU 42 102 102 GLU GLU B . n 
B 2 43 GLN 43 103 103 GLN GLN B . n 
B 2 44 GLY 44 104 104 GLY GLY B . n 
B 2 45 LYS 45 105 105 LYS LYS B . n 
B 2 46 ASN 46 106 106 ASN ASN B . n 
B 2 47 GLY 47 107 107 GLY GLY B . n 
B 2 48 ALA 48 108 108 ALA ALA B . n 
B 2 49 ILE 49 109 109 ILE ILE B . n 
B 2 50 ILE 50 110 110 ILE ILE B . n 
B 2 51 GLU 51 111 111 GLU GLU B . n 
B 2 52 ARG 52 112 112 ARG ARG B . n 
B 2 53 SER 53 113 113 SER SER B . n 
B 2 54 ARG 54 114 114 ARG ARG B . n 
B 2 55 PHE 55 115 115 PHE PHE B . n 
B 2 56 ILE 56 116 116 ILE ILE B . n 
B 2 57 LYS 57 117 117 LYS LYS B . n 
B 2 58 GLU 58 118 118 GLU GLU B . n 
B 2 59 ASN 59 119 119 ASN ASN B . n 
B 2 60 GLY 60 120 120 GLY GLY B . n 
C 3 1  GLN 1  121 121 GLN GLN C . n 
C 3 2  TRP 2  122 122 TRP TRP C . n 
C 3 3  TYR 3  123 123 TYR TYR C . n 
C 3 4  TYR 4  124 124 TYR TYR C . n 
C 3 5  ILE 5  125 125 ILE ILE C . n 
C 3 6  ASP 6  126 126 ASP ASP C . n 
C 3 7  GLY 7  127 127 GLY GLY C . n 
C 3 8  THR 8  128 128 THR THR C . n 
C 3 9  ARG 9  129 129 ARG ARG C . n 
C 3 10 PRO 10 130 130 PRO PRO C . n 
C 3 11 GLN 11 131 131 GLN GLN C . n 
C 3 12 LEU 12 132 132 LEU LEU C . n 
C 3 13 GLY 13 133 133 GLY GLY C . n 
C 3 14 ARG 14 134 134 ARG ARG C . n 
C 3 15 ASN 15 135 135 ASN ASN C . n 
C 3 16 ASP 16 136 136 ASP ASP C . n 
C 3 17 PRO 17 137 137 PRO PRO C . n 
C 3 18 CYS 18 138 138 CYS CYS C . n 
C 3 19 PRO 19 139 139 PRO PRO C . n 
C 3 20 CYS 20 140 140 CYS CYS C . n 
C 3 21 GLY 21 141 141 GLY GLY C . n 
C 3 22 SER 22 142 142 SER SER C . n 
C 3 23 GLY 23 143 143 GLY GLY C . n 
C 3 24 LYS 24 144 144 LYS LYS C . n 
C 3 25 LYS 25 145 145 LYS LYS C . n 
C 3 26 PHE 26 146 146 PHE PHE C . n 
C 3 27 LYS 27 147 147 LYS LYS C . n 
C 3 28 LYS 28 148 148 LYS LYS C . n 
C 3 29 CYS 29 149 149 CYS CYS C . n 
C 3 30 CYS 30 150 150 CYS CYS C . n 
C 3 31 GLY 31 151 151 GLY GLY C . n 
C 3 32 GLN 32 152 152 GLN GLN C . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 4 HOH 1  101 48 HOH HOH A . 
D 4 HOH 2  102 23 HOH HOH A . 
D 4 HOH 3  103 14 HOH HOH A . 
D 4 HOH 4  104 17 HOH HOH A . 
D 4 HOH 5  105 41 HOH HOH A . 
D 4 HOH 6  106 22 HOH HOH A . 
D 4 HOH 7  107 1  HOH HOH A . 
D 4 HOH 8  108 45 HOH HOH A . 
D 4 HOH 9  109 40 HOH HOH A . 
D 4 HOH 10 110 9  HOH HOH A . 
D 4 HOH 11 111 46 HOH HOH A . 
D 4 HOH 12 112 21 HOH HOH A . 
D 4 HOH 13 113 37 HOH HOH A . 
D 4 HOH 14 114 64 HOH HOH A . 
D 4 HOH 15 115 3  HOH HOH A . 
D 4 HOH 16 116 58 HOH HOH A . 
D 4 HOH 17 117 36 HOH HOH A . 
D 4 HOH 18 118 51 HOH HOH A . 
D 4 HOH 19 119 72 HOH HOH A . 
D 4 HOH 20 120 16 HOH HOH A . 
D 4 HOH 21 121 34 HOH HOH A . 
D 4 HOH 22 122 28 HOH HOH A . 
D 4 HOH 23 123 26 HOH HOH A . 
D 4 HOH 24 124 77 HOH HOH A . 
D 4 HOH 25 125 39 HOH HOH A . 
D 4 HOH 26 126 50 HOH HOH A . 
D 4 HOH 27 127 6  HOH HOH A . 
D 4 HOH 28 128 57 HOH HOH A . 
D 4 HOH 29 129 52 HOH HOH A . 
D 4 HOH 30 130 38 HOH HOH A . 
D 4 HOH 31 131 25 HOH HOH A . 
D 4 HOH 32 132 11 HOH HOH A . 
D 4 HOH 33 133 30 HOH HOH A . 
D 4 HOH 34 134 76 HOH HOH A . 
D 4 HOH 35 135 71 HOH HOH A . 
E 4 HOH 1  201 47 HOH HOH B . 
E 4 HOH 2  202 10 HOH HOH B . 
E 4 HOH 3  203 61 HOH HOH B . 
E 4 HOH 4  204 33 HOH HOH B . 
E 4 HOH 5  205 66 HOH HOH B . 
E 4 HOH 6  206 2  HOH HOH B . 
E 4 HOH 7  207 29 HOH HOH B . 
E 4 HOH 8  208 56 HOH HOH B . 
E 4 HOH 9  209 69 HOH HOH B . 
E 4 HOH 10 210 68 HOH HOH B . 
E 4 HOH 11 211 15 HOH HOH B . 
E 4 HOH 12 212 35 HOH HOH B . 
E 4 HOH 13 213 63 HOH HOH B . 
E 4 HOH 14 214 43 HOH HOH B . 
E 4 HOH 15 215 32 HOH HOH B . 
E 4 HOH 16 216 59 HOH HOH B . 
E 4 HOH 17 217 79 HOH HOH B . 
E 4 HOH 18 218 62 HOH HOH B . 
E 4 HOH 19 219 27 HOH HOH B . 
E 4 HOH 20 220 4  HOH HOH B . 
E 4 HOH 21 221 24 HOH HOH B . 
E 4 HOH 22 222 75 HOH HOH B . 
E 4 HOH 23 223 12 HOH HOH B . 
E 4 HOH 24 224 53 HOH HOH B . 
E 4 HOH 25 225 19 HOH HOH B . 
E 4 HOH 26 226 49 HOH HOH B . 
E 4 HOH 27 227 13 HOH HOH B . 
E 4 HOH 28 228 73 HOH HOH B . 
E 4 HOH 29 229 67 HOH HOH B . 
E 4 HOH 30 230 44 HOH HOH B . 
E 4 HOH 31 231 20 HOH HOH B . 
E 4 HOH 32 232 81 HOH HOH B . 
E 4 HOH 33 233 78 HOH HOH B . 
E 4 HOH 34 234 70 HOH HOH B . 
E 4 HOH 35 235 31 HOH HOH B . 
E 4 HOH 36 236 5  HOH HOH B . 
E 4 HOH 37 237 65 HOH HOH B . 
E 4 HOH 38 238 18 HOH HOH B . 
E 4 HOH 39 239 74 HOH HOH B . 
E 4 HOH 40 240 60 HOH HOH B . 
F 4 HOH 1  201 55 HOH HOH C . 
F 4 HOH 2  202 54 HOH HOH C . 
F 4 HOH 3  203 7  HOH HOH C . 
F 4 HOH 4  204 8  HOH HOH C . 
F 4 HOH 5  205 80 HOH HOH C . 
F 4 HOH 6  206 42 HOH HOH C . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.21.2_5419 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9L6B 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     58.937 
_cell.length_a_esd                 ? 
_cell.length_b                     58.937 
_cell.length_b_esd                 ? 
_cell.length_c                     124.367 
_cell.length_c_esd                 ? 
_cell.volume                       431997.476 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9L6B 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                96 
_symmetry.space_group_name_Hall            'P 4nw 2abw' 
_symmetry.space_group_name_H-M             'P 43 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9L6B 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.15 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          61.00 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.0 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '1.5 M Ammonium sulfate, 0.1 M BIS-TRIS propane pH 7.0' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 S 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-01-02 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    Si111 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.987 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL02U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.987 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL02U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          54.12 
_reflns.entry_id                                       9L6B 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.30 
_reflns.d_resolution_low                               53.26 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     10353 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           92.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          18.000 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.132 
_reflns.pdbx_Rpim_I_all                                0.020 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.131 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.303 
_reflns_shell.d_res_low                                     29.469 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           17.800 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             10294 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               0.019 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          98.9 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               64.65 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9L6B 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.30 
_refine.ls_d_res_low                             29.47 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     10294 
_refine.ls_number_reflns_R_free                  505 
_refine.ls_number_reflns_R_work                  9789 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.98 
_refine.ls_percent_reflns_R_free                 4.91 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2309 
_refine.ls_R_factor_R_free                       0.2712 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2290 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.37 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 27.7168 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2408 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.30 
_refine_hist.d_res_low                        29.47 
_refine_hist.number_atoms_solvent             81 
_refine_hist.number_atoms_total               1276 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1195 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0100  ? 1225 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.0884  ? 1650 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0535  ? 164  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0091  ? 217  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 17.4616 ? 449  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.30 2.53  . . 135 2351 100.00 . . . . 0.2292 . . . . . . . . . . . 0.2779 
'X-RAY DIFFRACTION' 2.53 2.90  . . 139 2386 99.92  . . . . 0.2587 . . . . . . . . . . . 0.3392 
'X-RAY DIFFRACTION' 2.90 3.65  . . 107 2463 100.00 . . . . 0.2555 . . . . . . . . . . . 0.3043 
'X-RAY DIFFRACTION' 3.65 29.47 . . 124 2589 100.00 . . . . 0.2118 . . . . . . . . . . . 0.2429 
# 
_struct.entry_id                     9L6B 
_struct.title                        'A ROS-Sensing Transcription Factor Promotes RpoS Accumulation to Resist Oxidative Stress' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9L6B 
_struct_keywords.text            'DNA binding, DNA BINDING PROTEIN' 
_struct_keywords.pdbx_keywords   'DNA BINDING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
F N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP A0A0F6B249_SALT1 A0A0F6B249 ? 1 MSQPCPCGSADEYSLCCGRIVSGERVAPDPSHLMRSRYCAFVMKDADYLIKSWHPTCNAA 1   
2 UNP A0A0F6B249_SALT1 A0A0F6B249 ? 2 AFRDDIIAGFANTRWLGLTIFEHTWSEAENTGYVSFIARFSEQGKNGAIIERSRFIKENG 61  
3 UNP A0A0F6B249_SALT1 A0A0F6B249 ? 3 QWYYIDGTRPQLGRNDPCPCGSGKKFKKCCGQ                             121 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9L6B A 1 ? 60 ? A0A0F6B249 1   ? 60  ? 1   60  
2 2 9L6B B 1 ? 60 ? A0A0F6B249 61  ? 120 ? 61  120 
3 3 9L6B C 1 ? 32 ? A0A0F6B249 121 ? 152 ? 121 152 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 4130 ? 
1 MORE         -35  ? 
1 'SSA (A^2)'  8780 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 GLU A 12 ? LEU A 15 ? GLU A 12 LEU A 15 5 ? 4  
HELX_P HELX_P2 AA2 CYS A 16 ? SER A 22 ? CYS A 16 SER A 22 1 ? 7  
HELX_P HELX_P3 AA3 ASP A 29 ? MET A 43 ? ASP A 29 MET A 43 1 ? 15 
HELX_P HELX_P4 AA4 ASP A 45 ? TRP A 53 ? ASP A 45 TRP A 53 1 ? 9  
HELX_P HELX_P5 AA5 HIS A 54 ? ASN A 58 ? HIS A 54 ASN A 58 5 ? 5  
HELX_P HELX_P6 AA6 PHE B 2  ? ALA B 11 ? PHE B 62 ALA B 71 1 ? 10 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 5  SG ? ? ? 1_555 A CYS 7  SG ? ? A CYS 5   A CYS 7   1_555 ? ? ? ? ? ? ? 2.068 ? ? 
disulf2 disulf ? ? A CYS 7  SG ? ? ? 1_555 A CYS 16 SG ? ? A CYS 7   A CYS 16  1_555 ? ? ? ? ? ? ? 2.068 ? ? 
disulf3 disulf ? ? A CYS 7  SG ? ? ? 1_555 A CYS 17 SG ? ? A CYS 7   A CYS 17  1_555 ? ? ? ? ? ? ? 2.044 ? ? 
disulf4 disulf ? ? C CYS 18 SG ? ? ? 1_555 C CYS 20 SG ? ? C CYS 138 C CYS 140 1_555 ? ? ? ? ? ? ? 2.046 ? ? 
disulf5 disulf ? ? C CYS 18 SG ? ? ? 1_555 C CYS 29 SG ? ? C CYS 138 C CYS 149 1_555 ? ? ? ? ? ? ? 2.040 ? ? 
disulf6 disulf ? ? C CYS 20 SG ? ? ? 1_555 C CYS 29 SG ? ? C CYS 140 C CYS 149 1_555 ? ? ? ? ? ? ? 2.011 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 5  ? CYS A 7  ? CYS A 5   ? 1_555 CYS A 7   ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 7  ? CYS A 16 ? CYS A 7   ? 1_555 CYS A 16  ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS A 7  ? CYS A 17 ? CYS A 7   ? 1_555 CYS A 17  ? 1_555 SG SG . . . None 'Disulfide bridge' 
4 CYS C 18 ? CYS C 20 ? CYS C 138 ? 1_555 CYS C 140 ? 1_555 SG SG . . . None 'Disulfide bridge' 
5 CYS C 18 ? CYS C 29 ? CYS C 138 ? 1_555 CYS C 149 ? 1_555 SG SG . . . None 'Disulfide bridge' 
6 CYS C 20 ? CYS C 29 ? CYS C 140 ? 1_555 CYS C 149 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   4 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ARG B 14 ? SER B 26 ? ARG B 74  SER B 86  
AA1 2 THR B 31 ? GLU B 42 ? THR B 91  GLU B 102 
AA1 3 LYS B 45 ? LYS B 57 ? LYS B 105 LYS B 117 
AA1 4 TRP C 2  ? THR C 8  ? TRP C 122 THR C 128 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LEU B 16 ? N LEU B 76  O ARG B 39 ? O ARG B 99  
AA1 2 3 N GLY B 32 ? N GLY B 92  O PHE B 55 ? O PHE B 115 
AA1 3 4 N ARG B 54 ? N ARG B 114 O ASP C 6  ? O ASP C 126 
# 
_pdbx_entry_details.entry_id                   9L6B 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_rmsd_bond.id                        1 
_pdbx_validate_rmsd_bond.PDB_model_num             1 
_pdbx_validate_rmsd_bond.auth_atom_id_1            CB 
_pdbx_validate_rmsd_bond.auth_asym_id_1            A 
_pdbx_validate_rmsd_bond.auth_comp_id_1            CYS 
_pdbx_validate_rmsd_bond.auth_seq_id_1             7 
_pdbx_validate_rmsd_bond.PDB_ins_code_1            ? 
_pdbx_validate_rmsd_bond.label_alt_id_1            ? 
_pdbx_validate_rmsd_bond.auth_atom_id_2            SG 
_pdbx_validate_rmsd_bond.auth_asym_id_2            A 
_pdbx_validate_rmsd_bond.auth_comp_id_2            CYS 
_pdbx_validate_rmsd_bond.auth_seq_id_2             7 
_pdbx_validate_rmsd_bond.PDB_ins_code_2            ? 
_pdbx_validate_rmsd_bond.label_alt_id_2            ? 
_pdbx_validate_rmsd_bond.bond_value                2.004 
_pdbx_validate_rmsd_bond.bond_target_value         1.818 
_pdbx_validate_rmsd_bond.bond_deviation            0.186 
_pdbx_validate_rmsd_bond.bond_standard_deviation   0.017 
_pdbx_validate_rmsd_bond.linker_flag               N 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             CA 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             CYS 
_pdbx_validate_rmsd_angle.auth_seq_id_1              7 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CB 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             CYS 
_pdbx_validate_rmsd_angle.auth_seq_id_2              7 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             SG 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             CYS 
_pdbx_validate_rmsd_angle.auth_seq_id_3              7 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                126.40 
_pdbx_validate_rmsd_angle.angle_target_value         114.20 
_pdbx_validate_rmsd_angle.angle_deviation            12.20 
_pdbx_validate_rmsd_angle.angle_standard_deviation   1.10 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 SER A 2   ? ? -136.65 -159.65 
2 1 CYS A 16  ? ? -107.41 -106.62 
3 1 ASN B 119 ? ? 70.02   165.09  
4 1 ILE C 125 ? ? -130.73 -57.44  
5 1 CYS C 149 ? ? -75.34  -74.14  
# 
_pdbx_validate_peptide_omega.id               1 
_pdbx_validate_peptide_omega.PDB_model_num    1 
_pdbx_validate_peptide_omega.auth_comp_id_1   SER 
_pdbx_validate_peptide_omega.auth_asym_id_1   A 
_pdbx_validate_peptide_omega.auth_seq_id_1    2 
_pdbx_validate_peptide_omega.PDB_ins_code_1   ? 
_pdbx_validate_peptide_omega.label_alt_id_1   ? 
_pdbx_validate_peptide_omega.auth_comp_id_2   GLN 
_pdbx_validate_peptide_omega.auth_asym_id_2   A 
_pdbx_validate_peptide_omega.auth_seq_id_2    3 
_pdbx_validate_peptide_omega.PDB_ins_code_2   ? 
_pdbx_validate_peptide_omega.label_alt_id_2   ? 
_pdbx_validate_peptide_omega.omega            -146.90 
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    A 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     116 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   D 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 -y+1/2,x+1/2,z+3/4  
3 y+1/2,-x+1/2,z+1/4  
4 x+1/2,-y+1/2,-z+1/4 
5 -x+1/2,y+1/2,-z+3/4 
6 -x,-y,z+1/2         
7 y,x,-z              
8 -y,-x,-z+1/2        
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
_pdbx_audit_support.funding_organization   'Other government' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   2jq5 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 43 21 2' 
_space_group.name_Hall        'P 4nw 2abw' 
_space_group.IT_number        96 
_space_group.crystal_system   tetragonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9L6B 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.016967 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.016967 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.008041 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . MET A 1 1  ? 34.17040  -21.91233 19.77788 1.000 64.36495  ? 1   MET A N   1 
ATOM   2    C CA  . MET A 1 1  ? 33.46899  -20.64312 19.90603 1.000 61.07151  ? 1   MET A CA  1 
ATOM   3    C C   . MET A 1 1  ? 31.99413  -20.99648 19.88850 1.000 62.14231  ? 1   MET A C   1 
ATOM   4    O O   . MET A 1 1  ? 31.64129  -22.11798 19.53865 1.000 72.04449  ? 1   MET A O   1 
ATOM   5    C CB  . MET A 1 1  ? 33.86159  -19.66646 18.79268 1.000 59.16218  ? 1   MET A CB  1 
ATOM   6    C CG  . MET A 1 1  ? 35.10707  -18.86341 19.10984 1.000 64.88904  ? 1   MET A CG  1 
ATOM   7    S SD  . MET A 1 1  ? 35.08793  -17.99376 20.70742 1.000 73.29988  ? 1   MET A SD  1 
ATOM   8    C CE  . MET A 1 1  ? 33.49990  -17.14327 20.70977 1.000 50.24011  ? 1   MET A CE  1 
ATOM   9    N N   . SER A 1 2  ? 31.10287  -20.10735 20.29662 1.000 51.10012  ? 2   SER A N   1 
ATOM   10   C CA  . SER A 1 2  ? 29.73639  -20.56827 20.45913 1.000 62.89358  ? 2   SER A CA  1 
ATOM   11   C C   . SER A 1 2  ? 28.76192  -19.54442 19.88495 1.000 67.46385  ? 2   SER A C   1 
ATOM   12   O O   . SER A 1 2  ? 29.11297  -18.69658 19.05401 1.000 55.74848  ? 2   SER A O   1 
ATOM   13   C CB  . SER A 1 2  ? 29.46809  -20.91641 21.92785 1.000 72.76202  ? 2   SER A CB  1 
ATOM   14   O OG  . SER A 1 2  ? 29.19838  -22.30825 22.05572 1.000 78.25186  ? 2   SER A OG  1 
ATOM   15   N N   . GLN A 1 3  ? 27.51266  -19.64188 20.34101 1.000 64.02191  ? 3   GLN A N   1 
ATOM   16   C CA  . GLN A 1 3  ? 26.33741  -19.32900 19.53273 1.000 58.09431  ? 3   GLN A CA  1 
ATOM   17   C C   . GLN A 1 3  ? 25.39646  -18.43528 20.32657 1.000 54.03932  ? 3   GLN A C   1 
ATOM   18   O O   . GLN A 1 3  ? 24.35316  -18.87715 20.81410 1.000 49.57923  ? 3   GLN A O   1 
ATOM   19   C CB  . GLN A 1 3  ? 25.65030  -20.62801 19.09821 1.000 61.43745  ? 3   GLN A CB  1 
ATOM   20   C CG  . GLN A 1 3  ? 24.32440  -20.47035 18.33193 1.000 58.99772  ? 3   GLN A CG  1 
ATOM   21   C CD  . GLN A 1 3  ? 23.75795  -21.80159 17.87242 1.000 62.29505  ? 3   GLN A CD  1 
ATOM   22   O OE1 . GLN A 1 3  ? 22.86124  -21.85185 17.02995 1.000 68.08298  ? 3   GLN A OE1 1 
ATOM   23   N NE2 . GLN A 1 3  ? 24.27425  -22.88734 18.42790 1.000 70.96636  ? 3   GLN A NE2 1 
ATOM   24   N N   . PRO A 1 4  ? 25.75199  -17.17254 20.49730 1.000 52.49402  ? 4   PRO A N   1 
ATOM   25   C CA  . PRO A 1 4  ? 24.83389  -16.23427 21.14249 1.000 49.94478  ? 4   PRO A CA  1 
ATOM   26   C C   . PRO A 1 4  ? 23.50197  -16.16619 20.42714 1.000 50.33422  ? 4   PRO A C   1 
ATOM   27   O O   . PRO A 1 4  ? 23.44460  -16.16790 19.19178 1.000 49.83415  ? 4   PRO A O   1 
ATOM   28   C CB  . PRO A 1 4  ? 25.57503  -14.90557 21.04377 1.000 53.12381  ? 4   PRO A CB  1 
ATOM   29   C CG  . PRO A 1 4  ? 26.62240  -15.12986 19.97057 1.000 53.47176  ? 4   PRO A CG  1 
ATOM   30   C CD  . PRO A 1 4  ? 27.03524  -16.53568 20.18879 1.000 56.76258  ? 4   PRO A CD  1 
ATOM   31   N N   . CYS A 1 5  ? 22.42707  -16.06821 21.22460 1.000 46.53766  ? 5   CYS A N   1 
ATOM   32   C CA  . CYS A 1 5  ? 21.07451  -16.17088 20.70711 1.000 47.71737  ? 5   CYS A CA  1 
ATOM   33   C C   . CYS A 1 5  ? 20.82480  -15.04840 19.69449 1.000 43.83444  ? 5   CYS A C   1 
ATOM   34   O O   . CYS A 1 5  ? 21.11994  -13.88495 19.99418 1.000 43.29261  ? 5   CYS A O   1 
ATOM   35   C CB  . CYS A 1 5  ? 20.03213  -16.08241 21.83923 1.000 46.12765  ? 5   CYS A CB  1 
ATOM   36   S SG  . CYS A 1 5  ? 18.32552  -16.45925 21.28144 1.000 49.49156  ? 5   CYS A SG  1 
ATOM   37   N N   . PRO A 1 6  ? 20.25274  -15.34304 18.53823 1.000 43.67736  ? 6   PRO A N   1 
ATOM   38   C CA  . PRO A 1 6  ? 19.73752  -14.23919 17.71004 1.000 45.96335  ? 6   PRO A CA  1 
ATOM   39   C C   . PRO A 1 6  ? 18.69162  -13.37385 18.43970 1.000 55.59532  ? 6   PRO A C   1 
ATOM   40   O O   . PRO A 1 6  ? 18.41175  -12.28210 17.90564 1.000 56.30798  ? 6   PRO A O   1 
ATOM   41   C CB  . PRO A 1 6  ? 19.14241  -14.95315 16.49380 1.000 48.68059  ? 6   PRO A CB  1 
ATOM   42   C CG  . PRO A 1 6  ? 19.85134  -16.27662 16.43297 1.000 46.21556  ? 6   PRO A CG  1 
ATOM   43   C CD  . PRO A 1 6  ? 20.05948  -16.64987 17.88621 1.000 47.35387  ? 6   PRO A CD  1 
ATOM   44   N N   . CYS A 1 7  ? 18.16536  -13.80533 19.63304 1.000 44.20270  ? 7   CYS A N   1 
ATOM   45   C CA  . CYS A 1 7  ? 17.33390  -13.02216 20.57135 1.000 53.94336  ? 7   CYS A CA  1 
ATOM   46   C C   . CYS A 1 7  ? 17.98656  -11.63921 20.54531 1.000 50.65052  ? 7   CYS A C   1 
ATOM   47   O O   . CYS A 1 7  ? 17.31714  -10.60837 20.43129 1.000 50.50252  ? 7   CYS A O   1 
ATOM   48   C CB  . CYS A 1 7  ? 17.22991  -13.61278 22.08327 1.000 30.51972  ? 7   CYS A CB  1 
ATOM   49   S SG  . CYS A 1 7  ? 17.02122  -15.53900 22.59589 1.000 28.21576  ? 7   CYS A SG  1 
ATOM   50   N N   . GLY A 1 8  ? 19.31530  -11.61437 20.56437 1.000 50.41284  ? 8   GLY A N   1 
ATOM   51   C CA  . GLY A 1 8  ? 20.05305  -10.43660 20.96696 1.000 50.19001  ? 8   GLY A CA  1 
ATOM   52   C C   . GLY A 1 8  ? 20.32102  -10.37870 22.45615 1.000 50.75900  ? 8   GLY A C   1 
ATOM   53   O O   . GLY A 1 8  ? 20.81354  -9.35280  22.94857 1.000 51.34707  ? 8   GLY A O   1 
ATOM   54   N N   . SER A 1 9  ? 20.03002  -11.45496 23.18806 1.000 48.00398  ? 9   SER A N   1 
ATOM   55   C CA  . SER A 1 9  ? 20.07769  -11.42430 24.65019 1.000 51.31086  ? 9   SER A CA  1 
ATOM   56   C C   . SER A 1 9  ? 21.47240  -11.64657 25.21376 1.000 58.75549  ? 9   SER A C   1 
ATOM   57   O O   . SER A 1 9  ? 21.64564  -11.50971 26.43197 1.000 54.47185  ? 9   SER A O   1 
ATOM   58   C CB  . SER A 1 9  ? 19.16783  -12.49516 25.22393 1.000 44.73120  ? 9   SER A CB  1 
ATOM   59   O OG  . SER A 1 9  ? 19.67892  -13.75619 24.82233 1.000 48.44954  ? 9   SER A OG  1 
ATOM   60   N N   . ALA A 1 10 ? 22.44998  -12.01535 24.37376 1.000 51.99193  ? 10  ALA A N   1 
ATOM   61   C CA  . ALA A 1 10 ? 23.81747  -12.32700 24.79317 1.000 55.15102  ? 10  ALA A CA  1 
ATOM   62   C C   . ALA A 1 10 ? 23.91539  -13.62494 25.58844 1.000 57.69206  ? 10  ALA A C   1 
ATOM   63   O O   . ALA A 1 10 ? 24.92766  -13.86768 26.25458 1.000 58.71967  ? 10  ALA A O   1 
ATOM   64   C CB  . ALA A 1 10 ? 24.44564  -11.18620 25.60744 1.000 54.35622  ? 10  ALA A CB  1 
ATOM   65   N N   . ASP A 1 11 ? 22.89030  -14.46783 25.55502 1.000 56.98532  ? 11  ASP A N   1 
ATOM   66   C CA  . ASP A 1 11 ? 22.99461  -15.82406 26.07101 1.000 48.41388  ? 11  ASP A CA  1 
ATOM   67   C C   . ASP A 1 11 ? 23.21315  -16.79795 24.92504 1.000 54.42733  ? 11  ASP A C   1 
ATOM   68   O O   . ASP A 1 11 ? 22.85661  -16.52426 23.77750 1.000 50.11505  ? 11  ASP A O   1 
ATOM   69   C CB  . ASP A 1 11 ? 21.72876  -16.21837 26.82661 1.000 54.41418  ? 11  ASP A CB  1 
ATOM   70   C CG  . ASP A 1 11 ? 21.68659  -15.64996 28.24253 1.000 54.94436  ? 11  ASP A CG  1 
ATOM   71   O OD1 . ASP A 1 11 ? 22.74510  -15.21544 28.73836 1.000 49.93598  ? 11  ASP A OD1 1 
ATOM   72   O OD2 . ASP A 1 11 ? 20.58757  -15.63675 28.83812 1.000 54.21004  ? 11  ASP A OD2 1 
ATOM   73   N N   . GLU A 1 12 ? 23.78540  -17.95507 25.24717 1.000 52.65418  ? 12  GLU A N   1 
ATOM   74   C CA  . GLU A 1 12 ? 23.82288  -19.04435 24.27626 1.000 51.74369  ? 12  GLU A CA  1 
ATOM   75   C C   . GLU A 1 12 ? 22.42187  -19.33701 23.75645 1.000 54.44368  ? 12  GLU A C   1 
ATOM   76   O O   . GLU A 1 12 ? 21.45814  -19.38113 24.52759 1.000 52.20175  ? 12  GLU A O   1 
ATOM   77   C CB  . GLU A 1 12 ? 24.40744  -20.31144 24.90930 1.000 52.37994  ? 12  GLU A CB  1 
ATOM   78   C CG  . GLU A 1 12 ? 25.91831  -20.26184 25.10849 1.000 52.91376  ? 12  GLU A CG  1 
ATOM   79   C CD  . GLU A 1 12 ? 26.65524  -20.20316 23.77554 1.000 61.97630  ? 12  GLU A CD  1 
ATOM   80   O OE1 . GLU A 1 12 ? 26.44222  -21.11225 22.92659 1.000 56.45780  ? 12  GLU A OE1 1 
ATOM   81   O OE2 . GLU A 1 12 ? 27.43201  -19.24129 23.58100 1.000 61.81568  ? 12  GLU A OE2 1 
ATOM   82   N N   . TYR A 1 13 ? 22.32222  -19.57408 22.44236 1.000 51.09727  ? 13  TYR A N   1 
ATOM   83   C CA  . TYR A 1 13 ? 21.02953  -19.85860 21.83491 1.000 52.03905  ? 13  TYR A CA  1 
ATOM   84   C C   . TYR A 1 13 ? 20.34034  -21.02367 22.52995 1.000 56.41604  ? 13  TYR A C   1 
ATOM   85   O O   . TYR A 1 13 ? 19.14771  -20.94774 22.84428 1.000 54.23812  ? 13  TYR A O   1 
ATOM   86   C CB  . TYR A 1 13 ? 21.18776  -20.15783 20.34395 1.000 49.12409  ? 13  TYR A CB  1 
ATOM   87   C CG  . TYR A 1 13 ? 19.95121  -20.80699 19.76313 1.000 55.89290  ? 13  TYR A CG  1 
ATOM   88   C CD1 . TYR A 1 13 ? 18.83065  -20.03923 19.43627 1.000 53.45110  ? 13  TYR A CD1 1 
ATOM   89   C CD2 . TYR A 1 13 ? 19.88838  -22.18576 19.55273 1.000 55.71591  ? 13  TYR A CD2 1 
ATOM   90   C CE1 . TYR A 1 13 ? 17.68536  -20.61859 18.92082 1.000 54.88978  ? 13  TYR A CE1 1 
ATOM   91   C CE2 . TYR A 1 13 ? 18.73455  -22.77869 19.03093 1.000 57.42452  ? 13  TYR A CE2 1 
ATOM   92   C CZ  . TYR A 1 13 ? 17.63676  -21.98010 18.71873 1.000 61.90109  ? 13  TYR A CZ  1 
ATOM   93   O OH  . TYR A 1 13 ? 16.48202  -22.53355 18.19315 1.000 66.92362  ? 13  TYR A OH  1 
ATOM   94   N N   . SER A 1 14 ? 21.08379  -22.10579 22.79407 1.000 55.24856  ? 14  SER A N   1 
ATOM   95   C CA  . SER A 1 14 ? 20.51786  -23.28447 23.44641 1.000 58.36595  ? 14  SER A CA  1 
ATOM   96   C C   . SER A 1 14 ? 19.99136  -22.99054 24.84588 1.000 56.40836  ? 14  SER A C   1 
ATOM   97   O O   . SER A 1 14 ? 19.18856  -23.77055 25.35902 1.000 58.90630  ? 14  SER A O   1 
ATOM   98   C CB  . SER A 1 14 ? 21.56515  -24.39491 23.54216 1.000 51.32941  ? 14  SER A CB  1 
ATOM   99   O OG  . SER A 1 14 ? 22.59302  -23.98490 24.42506 1.000 55.75214  ? 14  SER A OG  1 
ATOM   100  N N   . LEU A 1 15 ? 20.43966  -21.91225 25.48312 1.000 54.19633  ? 15  LEU A N   1 
ATOM   101  C CA  . LEU A 1 15 ? 19.93969  -21.51782 26.79584 1.000 54.90039  ? 15  LEU A CA  1 
ATOM   102  C C   . LEU A 1 15 ? 19.00704  -20.30614 26.76459 1.000 59.19991  ? 15  LEU A C   1 
ATOM   103  O O   . LEU A 1 15 ? 18.47493  -19.93760 27.81343 1.000 60.81553  ? 15  LEU A O   1 
ATOM   104  C CB  . LEU A 1 15 ? 21.11008  -21.22660 27.73912 1.000 53.73331  ? 15  LEU A CB  1 
ATOM   105  C CG  . LEU A 1 15 ? 22.17072  -22.32956 27.86276 1.000 60.26580  ? 15  LEU A CG  1 
ATOM   106  C CD1 . LEU A 1 15 ? 23.25217  -21.91756 28.84888 1.000 59.54868  ? 15  LEU A CD1 1 
ATOM   107  C CD2 . LEU A 1 15 ? 21.53480  -23.65703 28.27361 1.000 58.51857  ? 15  LEU A CD2 1 
ATOM   108  N N   . CYS A 1 16 ? 18.79774  -19.67141 25.60408 1.000 53.53789  ? 16  CYS A N   1 
ATOM   109  C CA  . CYS A 1 16 ? 17.86820  -18.54665 25.47273 1.000 54.78670  ? 16  CYS A CA  1 
ATOM   110  C C   . CYS A 1 16 ? 16.64468  -19.03803 24.71236 1.000 55.64094  ? 16  CYS A C   1 
ATOM   111  O O   . CYS A 1 16 ? 15.85488  -19.82803 25.22876 1.000 52.98027  ? 16  CYS A O   1 
ATOM   112  C CB  . CYS A 1 16 ? 18.53030  -17.34260 24.74730 1.000 50.74126  ? 16  CYS A CB  1 
ATOM   113  S SG  . CYS A 1 16 ? 17.58248  -15.74165 24.57586 1.000 51.12265  ? 16  CYS A SG  1 
ATOM   114  N N   . CYS A 1 17 ? 16.52246  -18.62711 23.45467 1.000 54.28304  ? 17  CYS A N   1 
ATOM   115  C CA  . CYS A 1 17 ? 15.34100  -18.95724 22.67184 1.000 57.33442  ? 17  CYS A CA  1 
ATOM   116  C C   . CYS A 1 17 ? 15.28290  -20.43407 22.26647 1.000 55.06699  ? 17  CYS A C   1 
ATOM   117  O O   . CYS A 1 17 ? 14.19078  -20.95068 22.00262 1.000 50.10856  ? 17  CYS A O   1 
ATOM   118  C CB  . CYS A 1 17 ? 15.30996  -18.01653 21.46502 1.000 48.18918  ? 17  CYS A CB  1 
ATOM   119  S SG  . CYS A 1 17 ? 15.20849  -16.28194 22.01175 1.000 46.31878  ? 17  CYS A SG  1 
ATOM   120  N N   . GLY A 1 18 ? 16.41570  -21.13933 22.26874 1.000 53.38443  ? 18  GLY A N   1 
ATOM   121  C CA  . GLY A 1 18 ? 16.43666  -22.51191 21.77517 1.000 54.14611  ? 18  GLY A CA  1 
ATOM   122  C C   . GLY A 1 18 ? 15.68642  -23.49885 22.65047 1.000 57.73833  ? 18  GLY A C   1 
ATOM   123  O O   . GLY A 1 18 ? 15.08879  -24.45352 22.14573 1.000 61.16664  ? 18  GLY A O   1 
ATOM   124  N N   . ARG A 1 19 ? 15.72598  -23.29924 23.96773 1.000 57.83322  ? 19  ARG A N   1 
ATOM   125  C CA  . ARG A 1 19 ? 14.93921  -24.12556 24.87989 1.000 58.96447  ? 19  ARG A CA  1 
ATOM   126  C C   . ARG A 1 19 ? 13.44469  -24.01642 24.60829 1.000 56.86716  ? 19  ARG A C   1 
ATOM   127  O O   . ARG A 1 19 ? 12.69248  -24.97136 24.84011 1.000 57.23224  ? 19  ARG A O   1 
ATOM   128  C CB  . ARG A 1 19 ? 15.20702  -23.71467 26.32656 1.000 56.89101  ? 19  ARG A CB  1 
ATOM   129  C CG  . ARG A 1 19 ? 16.55623  -24.06274 26.81855 1.000 63.78293  ? 19  ARG A CG  1 
ATOM   130  C CD  . ARG A 1 19 ? 16.60111  -23.95835 28.31342 1.000 63.93391  ? 19  ARG A CD  1 
ATOM   131  N NE  . ARG A 1 19 ? 16.60492  -22.58173 28.78622 1.000 65.36694  ? 19  ARG A NE  1 
ATOM   132  C CZ  . ARG A 1 19 ? 16.20169  -22.23279 30.00213 1.000 65.22870  ? 19  ARG A CZ  1 
ATOM   133  N NH1 . ARG A 1 19 ? 15.65765  -23.11400 30.82111 1.000 56.25535  ? 19  ARG A NH1 1 
ATOM   134  N NH2 . ARG A 1 19 ? 16.33361  -20.96813 30.39726 1.000 61.15463  ? 19  ARG A NH2 1 
ATOM   135  N N   . ILE A 1 20 ? 12.98654  -22.83939 24.18653 1.000 56.41056  ? 20  ILE A N   1 
ATOM   136  C CA  . ILE A 1 20 ? 11.56630  -22.64417 23.93146 1.000 55.27372  ? 20  ILE A CA  1 
ATOM   137  C C   . ILE A 1 20 ? 11.19054  -23.23089 22.57940 1.000 53.14757  ? 20  ILE A C   1 
ATOM   138  O O   . ILE A 1 20 ? 10.17149  -23.91328 22.44010 1.000 53.19213  ? 20  ILE A O   1 
ATOM   139  C CB  . ILE A 1 20 ? 11.21619  -21.14915 24.03067 1.000 53.55514  ? 20  ILE A CB  1 
ATOM   140  C CG1 . ILE A 1 20 ? 11.40371  -20.68964 25.48403 1.000 55.11944  ? 20  ILE A CG1 1 
ATOM   141  C CG2 . ILE A 1 20 ? 9.79837   -20.90699 23.54332 1.000 49.43911  ? 20  ILE A CG2 1 
ATOM   142  C CD1 . ILE A 1 20 ? 11.22462  -19.20362 25.72621 1.000 53.49063  ? 20  ILE A CD1 1 
ATOM   143  N N   . VAL A 1 21 ? 12.01128  -22.98501 21.56386 1.000 52.58321  ? 21  VAL A N   1 
ATOM   144  C CA  . VAL A 1 21 ? 11.69390  -23.50008 20.23721 1.000 54.22537  ? 21  VAL A CA  1 
ATOM   145  C C   . VAL A 1 21 ? 11.65093  -25.02468 20.25746 1.000 60.32630  ? 21  VAL A C   1 
ATOM   146  O O   . VAL A 1 21 ? 10.78214  -25.64570 19.63273 1.000 61.32273  ? 21  VAL A O   1 
ATOM   147  C CB  . VAL A 1 21 ? 12.70451  -22.95637 19.21916 1.000 54.67418  ? 21  VAL A CB  1 
ATOM   148  C CG1 . VAL A 1 21 ? 12.38949  -23.48224 17.83830 1.000 55.10747  ? 21  VAL A CG1 1 
ATOM   149  C CG2 . VAL A 1 21 ? 12.68718  -21.42238 19.25559 1.000 49.42906  ? 21  VAL A CG2 1 
ATOM   150  N N   . SER A 1 22 ? 12.54270  -25.64811 21.03297 1.000 60.99839  ? 22  SER A N   1 
ATOM   151  C CA  . SER A 1 22 ? 12.62916  -27.10089 21.08854 1.000 61.06591  ? 22  SER A CA  1 
ATOM   152  C C   . SER A 1 22 ? 11.46118  -27.73935 21.82592 1.000 64.72297  ? 22  SER A C   1 
ATOM   153  O O   . SER A 1 22 ? 11.31161  -28.96157 21.76383 1.000 68.75194  ? 22  SER A O   1 
ATOM   154  C CB  . SER A 1 22 ? 13.93823  -27.51616 21.76341 1.000 59.89043  ? 22  SER A CB  1 
ATOM   155  O OG  . SER A 1 22 ? 13.84783  -27.42521 23.17462 1.000 62.54414  ? 22  SER A OG  1 
ATOM   156  N N   . GLY A 1 23 ? 10.63830  -26.95774 22.52133 1.000 62.71882  ? 23  GLY A N   1 
ATOM   157  C CA  . GLY A 1 23 ? 9.55711   -27.50822 23.30908 1.000 57.54664  ? 23  GLY A CA  1 
ATOM   158  C C   . GLY A 1 23 ? 9.94410   -27.88211 24.71629 1.000 59.72140  ? 23  GLY A C   1 
ATOM   159  O O   . GLY A 1 23 ? 9.08212   -28.32195 25.48470 1.000 58.81284  ? 23  GLY A O   1 
ATOM   160  N N   . GLU A 1 24 ? 11.21148  -27.69657 25.08137 1.000 61.34175  ? 24  GLU A N   1 
ATOM   161  C CA  . GLU A 1 24 ? 11.70135  -28.11361 26.38846 1.000 60.40683  ? 24  GLU A CA  1 
ATOM   162  C C   . GLU A 1 24 ? 11.28658  -27.15244 27.49596 1.000 60.42691  ? 24  GLU A C   1 
ATOM   163  O O   . GLU A 1 24 ? 11.16959  -27.56326 28.65660 1.000 68.43703  ? 24  GLU A O   1 
ATOM   164  C CB  . GLU A 1 24 ? 13.22338  -28.24579 26.33028 1.000 64.59416  ? 24  GLU A CB  1 
ATOM   165  C CG  . GLU A 1 24 ? 13.91299  -28.34399 27.68704 1.000 68.19955  ? 24  GLU A CG  1 
ATOM   166  C CD  . GLU A 1 24 ? 15.32990  -27.78138 27.66506 1.000 75.71076  ? 24  GLU A CD  1 
ATOM   167  O OE1 . GLU A 1 24 ? 15.75035  -27.18185 28.68648 1.000 78.23354  ? 24  GLU A OE1 1 
ATOM   168  O OE2 . GLU A 1 24 ? 16.01367  -27.92402 26.62070 1.000 75.95106  ? 24  GLU A OE2 1 
ATOM   169  N N   . ARG A 1 25 ? 11.05736  -25.88200 27.17693 1.000 57.14725  ? 25  ARG A N   1 
ATOM   170  C CA  . ARG A 1 25 ? 10.65779  -24.90097 28.17962 1.000 60.42263  ? 25  ARG A CA  1 
ATOM   171  C C   . ARG A 1 25 ? 9.46788   -24.09578 27.66973 1.000 59.20381  ? 25  ARG A C   1 
ATOM   172  O O   . ARG A 1 25 ? 9.49642   -23.57982 26.55141 1.000 55.32128  ? 25  ARG A O   1 
ATOM   173  C CB  . ARG A 1 25 ? 11.82351  -23.96444 28.52968 1.000 58.66827  ? 25  ARG A CB  1 
ATOM   174  C CG  . ARG A 1 25 ? 11.58024  -23.05931 29.74643 1.000 57.98071  ? 25  ARG A CG  1 
ATOM   175  C CD  . ARG A 1 25 ? 12.34648  -21.73850 29.57875 1.000 60.03118  ? 25  ARG A CD  1 
ATOM   176  N NE  . ARG A 1 25 ? 12.14048  -20.81271 30.68571 1.000 64.16524  ? 25  ARG A NE  1 
ATOM   177  C CZ  . ARG A 1 25 ? 12.81410  -19.67845 30.86912 1.000 65.27817  ? 25  ARG A CZ  1 
ATOM   178  N NH1 . ARG A 1 25 ? 13.73471  -19.26555 30.00780 1.000 56.51104  ? 25  ARG A NH1 1 
ATOM   179  N NH2 . ARG A 1 25 ? 12.56757  -18.94483 31.95490 1.000 61.09500  ? 25  ARG A NH2 1 
ATOM   180  N N   . VAL A 1 26 ? 8.42511   -23.98701 28.49244 1.000 60.24856  ? 26  VAL A N   1 
ATOM   181  C CA  . VAL A 1 26 ? 7.31089   -23.10225 28.17616 1.000 55.87336  ? 26  VAL A CA  1 
ATOM   182  C C   . VAL A 1 26 ? 7.76088   -21.65314 28.32314 1.000 54.27109  ? 26  VAL A C   1 
ATOM   183  O O   . VAL A 1 26 ? 8.42665   -21.29049 29.30088 1.000 49.88053  ? 26  VAL A O   1 
ATOM   184  C CB  . VAL A 1 26 ? 6.11380   -23.40986 29.08570 1.000 58.34417  ? 26  VAL A CB  1 
ATOM   185  C CG1 . VAL A 1 26 ? 5.07578   -22.29848 29.00795 1.000 58.68995  ? 26  VAL A CG1 1 
ATOM   186  C CG2 . VAL A 1 26 ? 5.49501   -24.74499 28.69593 1.000 58.18913  ? 26  VAL A CG2 1 
ATOM   187  N N   . ALA A 1 27 ? 7.39568   -20.82133 27.35763 1.000 49.84878  ? 27  ALA A N   1 
ATOM   188  C CA  . ALA A 1 27 ? 7.78350   -19.41856 27.38897 1.000 48.25688  ? 27  ALA A CA  1 
ATOM   189  C C   . ALA A 1 27 ? 7.10176   -18.71452 28.54807 1.000 51.80503  ? 27  ALA A C   1 
ATOM   190  O O   . ALA A 1 27 ? 5.86743   -18.65816 28.58158 1.000 54.34034  ? 27  ALA A O   1 
ATOM   191  C CB  . ALA A 1 27 ? 7.42299   -18.73826 26.07930 1.000 47.76075  ? 27  ALA A CB  1 
ATOM   192  N N   . PRO A 1 28 ? 7.84559   -18.14422 29.50073 1.000 50.80304  ? 28  PRO A N   1 
ATOM   193  C CA  . PRO A 1 28 ? 7.21176   -17.61683 30.72097 1.000 49.75328  ? 28  PRO A CA  1 
ATOM   194  C C   . PRO A 1 28 ? 6.43086   -16.33529 30.52543 1.000 49.92714  ? 28  PRO A C   1 
ATOM   195  O O   . PRO A 1 28 ? 5.58435   -16.03969 31.37036 1.000 46.58647  ? 28  PRO A O   1 
ATOM   196  C CB  . PRO A 1 28 ? 8.39408   -17.38628 31.67019 1.000 51.22340  ? 28  PRO A CB  1 
ATOM   197  C CG  . PRO A 1 28 ? 9.58235   -17.22077 30.76786 1.000 52.60776  ? 28  PRO A CG  1 
ATOM   198  C CD  . PRO A 1 28 ? 9.31792   -18.08132 29.55811 1.000 51.86507  ? 28  PRO A CD  1 
ATOM   199  N N   . ASP A 1 29 ? 6.66573   -15.55337 29.47249 1.000 47.09397  ? 29  ASP A N   1 
ATOM   200  C CA  . ASP A 1 29 ? 5.95334   -14.29045 29.33805 1.000 47.96851  ? 29  ASP A CA  1 
ATOM   201  C C   . ASP A 1 29 ? 5.93059   -13.90686 27.86290 1.000 43.24170  ? 29  ASP A C   1 
ATOM   202  O O   . ASP A 1 29 ? 6.58343   -14.55748 27.04296 1.000 49.29398  ? 29  ASP A O   1 
ATOM   203  C CB  . ASP A 1 29 ? 6.59283   -13.19018 30.21383 1.000 44.76352  ? 29  ASP A CB  1 
ATOM   204  C CG  . ASP A 1 29 ? 8.03859   -12.91044 29.85870 1.000 50.23210  ? 29  ASP A CG  1 
ATOM   205  O OD1 . ASP A 1 29 ? 8.38853   -12.89459 28.65892 1.000 49.30775  ? 29  ASP A OD1 1 
ATOM   206  O OD2 . ASP A 1 29 ? 8.81655   -12.64385 30.80131 1.000 56.44634  ? 29  ASP A OD2 1 
ATOM   207  N N   . PRO A 1 30 ? 5.18914   -12.86185 27.48723 1.000 43.94108  ? 30  PRO A N   1 
ATOM   208  C CA  . PRO A 1 30 ? 5.14996   -12.50737 26.04897 1.000 43.66244  ? 30  PRO A CA  1 
ATOM   209  C C   . PRO A 1 30 ? 6.49633   -12.05774 25.49484 1.000 44.43408  ? 30  PRO A C   1 
ATOM   210  O O   . PRO A 1 30 ? 6.79335   -12.32724 24.32468 1.000 41.31202  ? 30  PRO A O   1 
ATOM   211  C CB  . PRO A 1 30 ? 4.08999   -11.39207 25.96513 1.000 40.22897  ? 30  PRO A CB  1 
ATOM   212  C CG  . PRO A 1 30 ? 3.65703   -11.09132 27.36190 1.000 46.59670  ? 30  PRO A CG  1 
ATOM   213  C CD  . PRO A 1 30 ? 4.13271   -12.18599 28.26840 1.000 43.14462  ? 30  PRO A CD  1 
ATOM   214  N N   . SER A 1 31 ? 7.33052   -11.39913 26.29868 1.000 46.24187  ? 31  SER A N   1 
ATOM   215  C CA  . SER A 1 31 ? 8.64497   -10.98718 25.81646 1.000 46.51303  ? 31  SER A CA  1 
ATOM   216  C C   . SER A 1 31 ? 9.47191   -12.18598 25.36430 1.000 45.30153  ? 31  SER A C   1 
ATOM   217  O O   . SER A 1 31 ? 10.05932  -12.17511 24.28256 1.000 48.40731  ? 31  SER A O   1 
ATOM   218  C CB  . SER A 1 31 ? 9.37384   -10.22338 26.91266 1.000 47.66554  ? 31  SER A CB  1 
ATOM   219  O OG  . SER A 1 31 ? 10.62437  -9.79258  26.44854 1.000 55.21938  ? 31  SER A OG  1 
ATOM   220  N N   . HIS A 1 32 ? 9.52532   -13.23673 26.18134 1.000 44.30595  ? 32  HIS A N   1 
ATOM   221  C CA  . HIS A 1 32 ? 10.24834  -14.43339 25.77798 1.000 44.44709  ? 32  HIS A CA  1 
ATOM   222  C C   . HIS A 1 32 ? 9.62689   -15.06588 24.54375 1.000 44.51572  ? 32  HIS A C   1 
ATOM   223  O O   . HIS A 1 32 ? 10.34202  -15.62232 23.70558 1.000 47.22088  ? 32  HIS A O   1 
ATOM   224  C CB  . HIS A 1 32 ? 10.29591  -15.44851 26.92595 1.000 47.94297  ? 32  HIS A CB  1 
ATOM   225  C CG  . HIS A 1 32 ? 11.12531  -15.00841 28.10154 1.000 56.95891  ? 32  HIS A CG  1 
ATOM   226  N ND1 . HIS A 1 32 ? 12.03366  -15.83965 28.72576 1.000 57.89924  ? 32  HIS A ND1 1 
ATOM   227  C CD2 . HIS A 1 32 ? 11.17768  -13.82744 28.77091 1.000 55.27459  ? 32  HIS A CD2 1 
ATOM   228  C CE1 . HIS A 1 32 ? 12.61752  -15.18659 29.71837 1.000 57.38298  ? 32  HIS A CE1 1 
ATOM   229  N NE2 . HIS A 1 32 ? 12.11926  -13.96193 29.76408 1.000 55.60564  ? 32  HIS A NE2 1 
ATOM   230  N N   . LEU A 1 33 ? 8.29409   -15.02823 24.42105 1.000 45.53500  ? 33  LEU A N   1 
ATOM   231  C CA  . LEU A 1 33 ? 7.66589   -15.62561 23.24330 1.000 43.23329  ? 33  LEU A CA  1 
ATOM   232  C C   . LEU A 1 33 ? 8.03572   -14.85010 21.99221 1.000 42.43499  ? 33  LEU A C   1 
ATOM   233  O O   . LEU A 1 33 ? 8.35794   -15.44363 20.95592 1.000 42.98770  ? 33  LEU A O   1 
ATOM   234  C CB  . LEU A 1 33 ? 6.13610   -15.66830 23.38841 1.000 44.12192  ? 33  LEU A CB  1 
ATOM   235  C CG  . LEU A 1 33 ? 5.44178   -16.57879 22.36518 1.000 46.22823  ? 33  LEU A CG  1 
ATOM   236  C CD1 . LEU A 1 33 ? 5.66197   -18.05688 22.75644 1.000 49.70042  ? 33  LEU A CD1 1 
ATOM   237  C CD2 . LEU A 1 33 ? 3.94372   -16.28950 22.20968 1.000 50.15502  ? 33  LEU A CD2 1 
ATOM   238  N N   . MET A 1 34 ? 7.96543   -13.52371 22.07641 1.000 41.13591  ? 34  MET A N   1 
ATOM   239  C CA  . MET A 1 34 ? 8.34575   -12.66152 20.96522 1.000 47.43688  ? 34  MET A CA  1 
ATOM   240  C C   . MET A 1 34 ? 9.76372   -12.96095 20.51285 1.000 45.07124  ? 34  MET A C   1 
ATOM   241  O O   . MET A 1 34 ? 10.01079  -13.18902 19.32987 1.000 40.44156  ? 34  MET A O   1 
ATOM   242  C CB  . MET A 1 34 ? 8.21931   -11.19470 21.37953 1.000 40.55506  ? 34  MET A CB  1 
ATOM   243  C CG  . MET A 1 34 ? 8.66919   -10.22865 20.28724 1.000 46.21422  ? 34  MET A CG  1 
ATOM   244  S SD  . MET A 1 34 ? 7.61950   -10.44129 18.82273 1.000 55.89693  ? 34  MET A SD  1 
ATOM   245  C CE  . MET A 1 34 ? 8.85629   -10.24002 17.52475 1.000 50.46834  ? 34  MET A CE  1 
ATOM   246  N N   . ARG A 1 35 ? 10.70398  -12.98841 21.45635 1.000 48.73471  ? 35  ARG A N   1 
ATOM   247  C CA  . ARG A 1 35 ? 12.07955  -13.32709 21.11337 1.000 49.32171  ? 35  ARG A CA  1 
ATOM   248  C C   . ARG A 1 35 ? 12.15057  -14.65461 20.39604 1.000 47.63752  ? 35  ARG A C   1 
ATOM   249  O O   . ARG A 1 35 ? 12.83376  -14.77478 19.37407 1.000 44.47659  ? 35  ARG A O   1 
ATOM   250  C CB  . ARG A 1 35 ? 12.94945  -13.36872 22.37163 1.000 39.65497  ? 35  ARG A CB  1 
ATOM   251  C CG  . ARG A 1 35 ? 13.46143  -12.01759 22.74805 1.000 43.12880  ? 35  ARG A CG  1 
ATOM   252  C CD  . ARG A 1 35 ? 14.24598  -12.09006 24.06020 1.000 47.31193  ? 35  ARG A CD  1 
ATOM   253  N NE  . ARG A 1 35 ? 14.32731  -10.78624 24.70149 1.000 51.00748  ? 35  ARG A NE  1 
ATOM   254  C CZ  . ARG A 1 35 ? 15.34573  -9.93871  24.57983 1.000 58.21624  ? 35  ARG A CZ  1 
ATOM   255  N NH1 . ARG A 1 35 ? 16.38298  -10.20327 23.78984 1.000 55.56501  ? 35  ARG A NH1 1 
ATOM   256  N NH2 . ARG A 1 35 ? 15.32292  -8.79132  25.26461 1.000 57.88429  ? 35  ARG A NH2 1 
ATOM   257  N N   . SER A 1 36 ? 11.44130  -15.66581 20.90710 1.000 44.10748  ? 36  SER A N   1 
ATOM   258  C CA  . SER A 1 36 ? 11.56264  -17.00189 20.32788 1.000 48.09296  ? 36  SER A CA  1 
ATOM   259  C C   . SER A 1 36 ? 10.94298  -17.07936 18.93671 1.000 45.95743  ? 36  SER A C   1 
ATOM   260  O O   . SER A 1 36 ? 11.39436  -17.87252 18.10493 1.000 45.64466  ? 36  SER A O   1 
ATOM   261  C CB  . SER A 1 36 ? 10.92433  -18.03905 21.24635 1.000 39.79206  ? 36  SER A CB  1 
ATOM   262  O OG  . SER A 1 36 ? 9.50669   -17.94599 21.17863 1.000 46.77213  ? 36  SER A OG  1 
ATOM   263  N N   . ARG A 1 37 ? 9.90042   -16.29530 18.65758 1.000 44.48923  ? 37  ARG A N   1 
ATOM   264  C CA  . ARG A 1 37 ? 9.36369   -16.29164 17.29572 1.000 46.36049  ? 37  ARG A CA  1 
ATOM   265  C C   . ARG A 1 37 ? 10.28160  -15.53558 16.34562 1.000 49.27176  ? 37  ARG A C   1 
ATOM   266  O O   . ARG A 1 37 ? 10.39068  -15.89962 15.17382 1.000 49.82532  ? 37  ARG A O   1 
ATOM   267  C CB  . ARG A 1 37 ? 7.95926   -15.67166 17.25677 1.000 46.62038  ? 37  ARG A CB  1 
ATOM   268  C CG  . ARG A 1 37 ? 6.85902   -16.46861 17.99677 1.000 44.20327  ? 37  ARG A CG  1 
ATOM   269  C CD  . ARG A 1 37 ? 5.52405   -15.70969 18.01130 1.000 46.58182  ? 37  ARG A CD  1 
ATOM   270  N NE  . ARG A 1 37 ? 5.02045   -15.36115 16.68549 1.000 43.75875  ? 37  ARG A NE  1 
ATOM   271  C CZ  . ARG A 1 37 ? 4.31678   -16.18171 15.91991 1.000 47.20367  ? 37  ARG A CZ  1 
ATOM   272  N NH1 . ARG A 1 37 ? 4.05059   -17.42081 16.29711 1.000 45.94121  ? 37  ARG A NH1 1 
ATOM   273  N NH2 . ARG A 1 37 ? 3.87659   -15.75380 14.73810 1.000 47.33152  ? 37  ARG A NH2 1 
ATOM   274  N N   . TYR A 1 38 ? 10.92945  -14.46728 16.81700 1.000 48.49055  ? 38  TYR A N   1 
ATOM   275  C CA  . TYR A 1 38 ? 11.92361  -13.80889 15.98239 1.000 48.36292  ? 38  TYR A CA  1 
ATOM   276  C C   . TYR A 1 38 ? 13.03509  -14.78495 15.60806 1.000 52.29138  ? 38  TYR A C   1 
ATOM   277  O O   . TYR A 1 38 ? 13.46112  -14.83843 14.44957 1.000 46.80348  ? 38  TYR A O   1 
ATOM   278  C CB  . TYR A 1 38 ? 12.48423  -12.58306 16.70420 1.000 46.61552  ? 38  TYR A CB  1 
ATOM   279  C CG  . TYR A 1 38 ? 13.65598  -11.95642 15.96471 1.000 53.10740  ? 38  TYR A CG  1 
ATOM   280  C CD1 . TYR A 1 38 ? 13.44723  -11.04845 14.92109 1.000 48.97916  ? 38  TYR A CD1 1 
ATOM   281  C CD2 . TYR A 1 38 ? 14.96990  -12.28977 16.28974 1.000 52.74228  ? 38  TYR A CD2 1 
ATOM   282  C CE1 . TYR A 1 38 ? 14.51287  -10.48836 14.23334 1.000 53.61272  ? 38  TYR A CE1 1 
ATOM   283  C CE2 . TYR A 1 38 ? 16.05350  -11.72100 15.60121 1.000 47.97228  ? 38  TYR A CE2 1 
ATOM   284  C CZ  . TYR A 1 38 ? 15.81762  -10.82562 14.57646 1.000 52.70138  ? 38  TYR A CZ  1 
ATOM   285  O OH  . TYR A 1 38 ? 16.87765  -10.26009 13.88460 1.000 52.93162  ? 38  TYR A OH  1 
ATOM   286  N N   . CYS A 1 39 ? 13.48993  -15.59247 16.57274 1.000 48.66638  ? 39  CYS A N   1 
ATOM   287  C CA  . CYS A 1 39 ? 14.47351  -16.62744 16.27397 1.000 49.19582  ? 39  CYS A CA  1 
ATOM   288  C C   . CYS A 1 39 ? 13.96652  -17.57601 15.20915 1.000 53.54351  ? 39  CYS A C   1 
ATOM   289  O O   . CYS A 1 39 ? 14.67238  -17.85598 14.23983 1.000 54.65440  ? 39  CYS A O   1 
ATOM   290  C CB  . CYS A 1 39 ? 14.83978  -17.40949 17.52837 1.000 51.22139  ? 39  CYS A CB  1 
ATOM   291  S SG  . CYS A 1 39 ? 16.00051  -16.50321 18.54638 1.000 55.48838  ? 39  CYS A SG  1 
ATOM   292  N N   . ALA A 1 40 ? 12.74506  -18.09055 15.37606 1.000 51.51807  ? 40  ALA A N   1 
ATOM   293  C CA  . ALA A 1 40 ? 12.18178  -19.00202 14.38314 1.000 51.32650  ? 40  ALA A CA  1 
ATOM   294  C C   . ALA A 1 40 ? 12.10200  -18.36819 12.99815 1.000 53.17974  ? 40  ALA A C   1 
ATOM   295  O O   . ALA A 1 40 ? 12.20409  -19.07507 11.99327 1.000 54.00899  ? 40  ALA A O   1 
ATOM   296  C CB  . ALA A 1 40 ? 10.79851  -19.48563 14.82260 1.000 47.70229  ? 40  ALA A CB  1 
ATOM   297  N N   . PHE A 1 41 ? 11.92351  -17.05053 12.90723 1.000 52.47369  ? 41  PHE A N   1 
ATOM   298  C CA  . PHE A 1 41 ? 11.99718  -16.41170 11.59443 1.000 52.22567  ? 41  PHE A CA  1 
ATOM   299  C C   . PHE A 1 41 ? 13.42461  -16.43388 11.05808 1.000 55.12472  ? 41  PHE A C   1 
ATOM   300  O O   . PHE A 1 41 ? 13.65808  -16.74577 9.88160  1.000 58.02179  ? 41  PHE A O   1 
ATOM   301  C CB  . PHE A 1 41 ? 11.48409  -14.97676 11.66866 1.000 48.63516  ? 41  PHE A CB  1 
ATOM   302  C CG  . PHE A 1 41 ? 10.00831  -14.85763 11.49892 1.000 56.05020  ? 41  PHE A CG  1 
ATOM   303  C CD1 . PHE A 1 41 ? 9.41564   -15.12294 10.27254 1.000 56.33556  ? 41  PHE A CD1 1 
ATOM   304  C CD2 . PHE A 1 41 ? 9.20913   -14.46390 12.55509 1.000 58.65275  ? 41  PHE A CD2 1 
ATOM   305  C CE1 . PHE A 1 41 ? 8.04864   -15.01394 10.11375 1.000 59.84575  ? 41  PHE A CE1 1 
ATOM   306  C CE2 . PHE A 1 41 ? 7.83524   -14.35217 12.40402 1.000 58.24892  ? 41  PHE A CE2 1 
ATOM   307  C CZ  . PHE A 1 41 ? 7.25445   -14.62390 11.18581 1.000 55.54110  ? 41  PHE A CZ  1 
ATOM   308  N N   . VAL A 1 42 ? 14.38286  -16.06341 11.90551 1.000 51.86803  ? 42  VAL A N   1 
ATOM   309  C CA  . VAL A 1 42 ? 15.80012  -16.13652 11.56013 1.000 54.16336  ? 42  VAL A CA  1 
ATOM   310  C C   . VAL A 1 42 ? 16.18017  -17.55549 11.14844 1.000 55.73947  ? 42  VAL A C   1 
ATOM   311  O O   . VAL A 1 42 ? 16.81088  -17.76949 10.10852 1.000 58.42312  ? 42  VAL A O   1 
ATOM   312  C CB  . VAL A 1 42 ? 16.64497  -15.64794 12.75188 1.000 54.27520  ? 42  VAL A CB  1 
ATOM   313  C CG1 . VAL A 1 42 ? 18.11331  -16.03104 12.58207 1.000 55.77641  ? 42  VAL A CG1 1 
ATOM   314  C CG2 . VAL A 1 42 ? 16.47596  -14.14414 12.95357 1.000 46.58790  ? 42  VAL A CG2 1 
ATOM   315  N N   . MET A 1 43 ? 15.78363  -18.54666 11.94476 1.000 53.52201  ? 43  MET A N   1 
ATOM   316  C CA  . MET A 1 43 ? 16.16434  -19.93398 11.71731 1.000 56.85831  ? 43  MET A CA  1 
ATOM   317  C C   . MET A 1 43 ? 15.23981  -20.65563 10.74858 1.000 55.82430  ? 43  MET A C   1 
ATOM   318  O O   . MET A 1 43 ? 15.38779  -21.86974 10.56463 1.000 57.39171  ? 43  MET A O   1 
ATOM   319  C CB  . MET A 1 43 ? 16.21344  -20.69787 13.04451 1.000 59.70627  ? 43  MET A CB  1 
ATOM   320  C CG  . MET A 1 43 ? 16.73499  -19.89052 14.23090 1.000 62.59802  ? 43  MET A CG  1 
ATOM   321  S SD  . MET A 1 43 ? 18.39690  -20.20551 14.82436 1.000 81.65024  ? 43  MET A SD  1 
ATOM   322  C CE  . MET A 1 43 ? 18.22510  -21.83591 15.53619 1.000 73.18695  ? 43  MET A CE  1 
ATOM   323  N N   . LYS A 1 44 ? 14.28450  -19.94325 10.14858 1.000 57.94990  ? 44  LYS A N   1 
ATOM   324  C CA  . LYS A 1 44 ? 13.36563  -20.49890 9.15579  1.000 55.37581  ? 44  LYS A CA  1 
ATOM   325  C C   . LYS A 1 44 ? 12.68571  -21.77408 9.65487  1.000 55.94176  ? 44  LYS A C   1 
ATOM   326  O O   . LYS A 1 44 ? 12.52027  -22.75013 8.91881  1.000 59.74584  ? 44  LYS A O   1 
ATOM   327  C CB  . LYS A 1 44 ? 14.08855  -20.74332 7.83002  1.000 60.06898  ? 44  LYS A CB  1 
ATOM   328  C CG  . LYS A 1 44 ? 14.74723  -19.49181 7.22836  1.000 59.25090  ? 44  LYS A CG  1 
ATOM   329  C CD  . LYS A 1 44 ? 15.38176  -19.83512 5.87351  1.000 63.56771  ? 44  LYS A CD  1 
ATOM   330  C CE  . LYS A 1 44 ? 16.02804  -18.63222 5.21213  1.000 63.19317  ? 44  LYS A CE  1 
ATOM   331  N NZ  . LYS A 1 44 ? 17.39572  -18.40591 5.73374  1.000 69.57521  ? 44  LYS A NZ  1 
ATOM   332  N N   . ASP A 1 45 ? 12.25015  -21.74383 10.91768 1.000 53.00880  ? 45  ASP A N   1 
ATOM   333  C CA  . ASP A 1 45 ? 11.52299  -22.84819 11.55321 1.000 55.72749  ? 45  ASP A CA  1 
ATOM   334  C C   . ASP A 1 45 ? 10.01909  -22.56581 11.47564 1.000 62.68265  ? 45  ASP A C   1 
ATOM   335  O O   . ASP A 1 45 ? 9.42245   -22.02791 12.41403 1.000 55.82310  ? 45  ASP A O   1 
ATOM   336  C CB  . ASP A 1 45 ? 11.98775  -23.01556 12.99923 1.000 58.57842  ? 45  ASP A CB  1 
ATOM   337  C CG  . ASP A 1 45 ? 11.34279  -24.20842 13.70172 1.000 59.08950  ? 45  ASP A CG  1 
ATOM   338  O OD1 . ASP A 1 45 ? 10.39312  -24.79254 13.13954 1.000 58.76883  ? 45  ASP A OD1 1 
ATOM   339  O OD2 . ASP A 1 45 ? 11.80069  -24.57517 14.81740 1.000 56.47743  ? 45  ASP A OD2 1 
ATOM   340  N N   . ALA A 1 46 ? 9.39219   -22.97676 10.36154 1.000 58.35465  ? 46  ALA A N   1 
ATOM   341  C CA  . ALA A 1 46 ? 7.96814   -22.71417 10.16848 1.000 55.06266  ? 46  ALA A CA  1 
ATOM   342  C C   . ALA A 1 46 ? 7.10482   -23.44483 11.18640 1.000 55.54619  ? 46  ALA A C   1 
ATOM   343  O O   . ALA A 1 46 ? 6.05549   -22.93280 11.57729 1.000 56.53382  ? 46  ALA A O   1 
ATOM   344  C CB  . ALA A 1 46 ? 7.54153   -23.10327 8.75423  1.000 60.19903  ? 46  ALA A CB  1 
ATOM   345  N N   . ASP A 1 47 ? 7.52223   -24.62685 11.64006 1.000 59.09295  ? 47  ASP A N   1 
ATOM   346  C CA  . ASP A 1 47 ? 6.67675   -25.38964 12.55574 1.000 57.87242  ? 47  ASP A CA  1 
ATOM   347  C C   . ASP A 1 47 ? 6.56958   -24.71657 13.91958 1.000 56.69798  ? 47  ASP A C   1 
ATOM   348  O O   . ASP A 1 47 ? 5.50653   -24.75652 14.54669 1.000 53.26514  ? 47  ASP A O   1 
ATOM   349  C CB  . ASP A 1 47 ? 7.20155   -26.81654 12.69078 1.000 61.63164  ? 47  ASP A CB  1 
ATOM   350  C CG  . ASP A 1 47 ? 7.09350   -27.60206 11.38455 1.000 68.28034  ? 47  ASP A CG  1 
ATOM   351  O OD1 . ASP A 1 47 ? 6.08823   -27.43140 10.65013 1.000 71.18043  ? 47  ASP A OD1 1 
ATOM   352  O OD2 . ASP A 1 47 ? 8.01664   -28.38085 11.08093 1.000 68.30374  ? 47  ASP A OD2 1 
ATOM   353  N N   . TYR A 1 48 ? 7.64626   -24.08890 14.40385 1.000 54.39033  ? 48  TYR A N   1 
ATOM   354  C CA  . TYR A 1 48 ? 7.52697   -23.39770 15.68360 1.000 53.24710  ? 48  TYR A CA  1 
ATOM   355  C C   . TYR A 1 48 ? 6.63768   -22.16879 15.55877 1.000 52.69024  ? 48  TYR A C   1 
ATOM   356  O O   . TYR A 1 48 ? 5.90694   -21.83292 16.49512 1.000 51.42713  ? 48  TYR A O   1 
ATOM   357  C CB  . TYR A 1 48 ? 8.89086   -22.98687 16.26169 1.000 50.26145  ? 48  TYR A CB  1 
ATOM   358  C CG  . TYR A 1 48 ? 8.66970   -22.21672 17.55122 1.000 47.97740  ? 48  TYR A CG  1 
ATOM   359  C CD1 . TYR A 1 48 ? 8.16576   -22.86004 18.66881 1.000 49.93898  ? 48  TYR A CD1 1 
ATOM   360  C CD2 . TYR A 1 48 ? 8.86300   -20.83709 17.62025 1.000 46.04754  ? 48  TYR A CD2 1 
ATOM   361  C CE1 . TYR A 1 48 ? 7.90300   -22.16390 19.84535 1.000 52.01245  ? 48  TYR A CE1 1 
ATOM   362  C CE2 . TYR A 1 48 ? 8.59894   -20.12639 18.80220 1.000 48.06530  ? 48  TYR A CE2 1 
ATOM   363  C CZ  . TYR A 1 48 ? 8.11842   -20.80597 19.90546 1.000 49.41376  ? 48  TYR A CZ  1 
ATOM   364  O OH  . TYR A 1 48 ? 7.84593   -20.14152 21.07990 1.000 50.11126  ? 48  TYR A OH  1 
ATOM   365  N N   . LEU A 1 49 ? 6.70589   -21.46625 14.42706 1.000 52.80639  ? 49  LEU A N   1 
ATOM   366  C CA  . LEU A 1 49 ? 5.82424   -20.32039 14.22987 1.000 52.62617  ? 49  LEU A CA  1 
ATOM   367  C C   . LEU A 1 49 ? 4.36911   -20.74682 14.22341 1.000 51.83782  ? 49  LEU A C   1 
ATOM   368  O O   . LEU A 1 49 ? 3.51155   -20.09299 14.83317 1.000 50.37029  ? 49  LEU A O   1 
ATOM   369  C CB  . LEU A 1 49 ? 6.16618   -19.61752 12.92844 1.000 48.98634  ? 49  LEU A CB  1 
ATOM   370  C CG  . LEU A 1 49 ? 7.56098   -19.01583 12.96792 1.000 51.59429  ? 49  LEU A CG  1 
ATOM   371  C CD1 . LEU A 1 49 ? 7.95064   -18.50982 11.58827 1.000 53.54124  ? 49  LEU A CD1 1 
ATOM   372  C CD2 . LEU A 1 49 ? 7.57430   -17.89806 13.97663 1.000 44.54463  ? 49  LEU A CD2 1 
ATOM   373  N N   . ILE A 1 50 ? 4.07075   -21.83840 13.53109 1.000 51.96756  ? 50  ILE A N   1 
ATOM   374  C CA  . ILE A 1 50 ? 2.71034   -22.35438 13.53439 1.000 52.95829  ? 50  ILE A CA  1 
ATOM   375  C C   . ILE A 1 50 ? 2.28109   -22.67283 14.95617 1.000 52.80201  ? 50  ILE A C   1 
ATOM   376  O O   . ILE A 1 50 ? 1.21961   -22.23770 15.41019 1.000 52.95466  ? 50  ILE A O   1 
ATOM   377  C CB  . ILE A 1 50 ? 2.60884   -23.58210 12.61733 1.000 53.14106  ? 50  ILE A CB  1 
ATOM   378  C CG1 . ILE A 1 50 ? 2.71171   -23.13533 11.16671 1.000 59.61031  ? 50  ILE A CG1 1 
ATOM   379  C CG2 . ILE A 1 50 ? 1.32774   -24.34748 12.89297 1.000 56.32799  ? 50  ILE A CG2 1 
ATOM   380  C CD1 . ILE A 1 50 ? 3.15963   -24.22531 10.22959 1.000 64.88356  ? 50  ILE A CD1 1 
ATOM   381  N N   . LYS A 1 51 ? 3.13465   -23.38418 15.70191 1.000 52.44482  ? 51  LYS A N   1 
ATOM   382  C CA  . LYS A 1 51 ? 2.78727   -23.83424 17.04603 1.000 51.12381  ? 51  LYS A CA  1 
ATOM   383  C C   . LYS A 1 51 ? 2.62545   -22.68567 18.04656 1.000 53.13397  ? 51  LYS A C   1 
ATOM   384  O O   . LYS A 1 51 ? 1.92209   -22.85391 19.05586 1.000 48.95413  ? 51  LYS A O   1 
ATOM   385  C CB  . LYS A 1 51 ? 3.85142   -24.81385 17.56635 1.000 53.71704  ? 51  LYS A CB  1 
ATOM   386  C CG  . LYS A 1 51 ? 3.43469   -25.62454 18.79407 1.000 53.12268  ? 51  LYS A CG  1 
ATOM   387  C CD  . LYS A 1 51 ? 4.49640   -25.60226 19.89599 1.000 64.50182  ? 51  LYS A CD  1 
ATOM   388  C CE  . LYS A 1 51 ? 4.58645   -24.22422 20.59445 1.000 65.49831  ? 51  LYS A CE  1 
ATOM   389  N NZ  . LYS A 1 51 ? 5.41956   -24.24863 21.88302 1.000 63.84670  ? 51  LYS A NZ  1 
ATOM   390  N N   . SER A 1 52 ? 3.26563   -21.53797 17.81927 1.000 47.48661  ? 52  SER A N   1 
ATOM   391  C CA  . SER A 1 52 ? 3.12964   -20.41160 18.73257 1.000 52.17984  ? 52  SER A CA  1 
ATOM   392  C C   . SER A 1 52 ? 2.12157   -19.37617 18.25379 1.000 49.81264  ? 52  SER A C   1 
ATOM   393  O O   . SER A 1 52 ? 1.93347   -18.36211 18.93242 1.000 48.36935  ? 52  SER A O   1 
ATOM   394  C CB  . SER A 1 52 ? 4.49624   -19.74835 18.98640 1.000 49.80153  ? 52  SER A CB  1 
ATOM   395  O OG  . SER A 1 52 ? 5.18855   -19.48655 17.78185 1.000 45.13299  ? 52  SER A OG  1 
ATOM   396  N N   . TRP A 1 53 ? 1.46393   -19.61590 17.11928 1.000 49.89645  ? 53  TRP A N   1 
ATOM   397  C CA  . TRP A 1 53 ? 0.34783   -18.78803 16.67584 1.000 48.82978  ? 53  TRP A CA  1 
ATOM   398  C C   . TRP A 1 53 ? -0.93883  -19.21826 17.38546 1.000 45.74591  ? 53  TRP A C   1 
ATOM   399  O O   . TRP A 1 53 ? -1.23611  -20.41530 17.48567 1.000 45.10502  ? 53  TRP A O   1 
ATOM   400  C CB  . TRP A 1 53 ? 0.16913   -18.90314 15.15097 1.000 46.33546  ? 53  TRP A CB  1 
ATOM   401  C CG  . TRP A 1 53 ? 0.02926   -17.59183 14.48098 1.000 48.04461  ? 53  TRP A CG  1 
ATOM   402  C CD1 . TRP A 1 53 ? -0.91689  -16.64802 14.73613 1.000 48.65370  ? 53  TRP A CD1 1 
ATOM   403  C CD2 . TRP A 1 53 ? 0.86239   -17.05786 13.44155 1.000 52.28932  ? 53  TRP A CD2 1 
ATOM   404  N NE1 . TRP A 1 53 ? -0.72131  -15.55256 13.92696 1.000 48.30018  ? 53  TRP A NE1 1 
ATOM   405  C CE2 . TRP A 1 53 ? 0.36055   -15.78116 13.12057 1.000 50.58933  ? 53  TRP A CE2 1 
ATOM   406  C CE3 . TRP A 1 53 ? 1.97674   -17.54008 12.74411 1.000 49.27901  ? 53  TRP A CE3 1 
ATOM   407  C CZ2 . TRP A 1 53 ? 0.93883   -14.97339 12.14414 1.000 50.43061  ? 53  TRP A CZ2 1 
ATOM   408  C CZ3 . TRP A 1 53 ? 2.54869   -16.74000 11.78135 1.000 46.05291  ? 53  TRP A CZ3 1 
ATOM   409  C CH2 . TRP A 1 53 ? 2.03374   -15.46805 11.48909 1.000 50.05592  ? 53  TRP A CH2 1 
ATOM   410  N N   . HIS A 1 54 ? -1.71094  -18.23629 17.84797 1.000 42.27163  ? 54  HIS A N   1 
ATOM   411  C CA  . HIS A 1 54 ? -2.97829  -18.51518 18.52039 1.000 46.63158  ? 54  HIS A CA  1 
ATOM   412  C C   . HIS A 1 54 ? -3.83418  -19.46181 17.68222 1.000 48.95623  ? 54  HIS A C   1 
ATOM   413  O O   . HIS A 1 54 ? -3.94826  -19.27179 16.46528 1.000 49.53679  ? 54  HIS A O   1 
ATOM   414  C CB  . HIS A 1 54 ? -3.75760  -17.21735 18.78058 1.000 43.71872  ? 54  HIS A CB  1 
ATOM   415  C CG  . HIS A 1 54 ? -4.92606  -17.40544 19.69890 1.000 51.39330  ? 54  HIS A CG  1 
ATOM   416  N ND1 . HIS A 1 54 ? -6.12468  -17.94546 19.27928 1.000 45.10898  ? 54  HIS A ND1 1 
ATOM   417  C CD2 . HIS A 1 54 ? -5.05765  -17.17758 21.03054 1.000 48.38619  ? 54  HIS A CD2 1 
ATOM   418  C CE1 . HIS A 1 54 ? -6.95308  -18.01480 20.30699 1.000 51.47237  ? 54  HIS A CE1 1 
ATOM   419  N NE2 . HIS A 1 54 ? -6.32799  -17.55971 21.38108 1.000 52.64266  ? 54  HIS A NE2 1 
ATOM   420  N N   . PRO A 1 55 ? -4.46631  -20.47158 18.29348 1.000 52.24904  ? 55  PRO A N   1 
ATOM   421  C CA  . PRO A 1 55 ? -5.13824  -21.51063 17.49633 1.000 48.34761  ? 55  PRO A CA  1 
ATOM   422  C C   . PRO A 1 55 ? -6.24257  -20.98831 16.58884 1.000 49.53222  ? 55  PRO A C   1 
ATOM   423  O O   . PRO A 1 55 ? -6.45760  -21.56389 15.51872 1.000 50.58658  ? 55  PRO A O   1 
ATOM   424  C CB  . PRO A 1 55 ? -5.70763  -22.46590 18.55926 1.000 46.42968  ? 55  PRO A CB  1 
ATOM   425  C CG  . PRO A 1 55 ? -5.07478  -22.09442 19.82442 1.000 49.47422  ? 55  PRO A CG  1 
ATOM   426  C CD  . PRO A 1 55 ? -4.67022  -20.67199 19.73659 1.000 51.12832  ? 55  PRO A CD  1 
ATOM   427  N N   . THR A 1 56 ? -6.94276  -19.91531 16.96074 1.000 49.66046  ? 56  THR A N   1 
ATOM   428  C CA  . THR A 1 56 ? -8.03218  -19.44715 16.10801 1.000 53.33588  ? 56  THR A CA  1 
ATOM   429  C C   . THR A 1 56 ? -7.54477  -18.92327 14.76449 1.000 52.60443  ? 56  THR A C   1 
ATOM   430  O O   . THR A 1 56 ? -8.33143  -18.85434 13.81250 1.000 52.65763  ? 56  THR A O   1 
ATOM   431  C CB  . THR A 1 56 ? -8.86136  -18.36922 16.81044 1.000 48.06133  ? 56  THR A CB  1 
ATOM   432  O OG1 . THR A 1 56 ? -10.08230 -18.20797 16.09031 1.000 47.07560  ? 56  THR A OG1 1 
ATOM   433  C CG2 . THR A 1 56 ? -8.14420  -17.02039 16.85262 1.000 43.99197  ? 56  THR A CG2 1 
ATOM   434  N N   . CYS A 1 57 ? -6.26166  -18.59088 14.64623 1.000 56.30719  ? 57  CYS A N   1 
ATOM   435  C CA  . CYS A 1 57 ? -5.75524  -18.07900 13.38130 1.000 49.28567  ? 57  CYS A CA  1 
ATOM   436  C C   . CYS A 1 57 ? -5.54189  -19.17403 12.35055 1.000 49.92656  ? 57  CYS A C   1 
ATOM   437  O O   . CYS A 1 57 ? -5.36973  -18.86587 11.16291 1.000 50.24826  ? 57  CYS A O   1 
ATOM   438  C CB  . CYS A 1 57 ? -4.46013  -17.32313 13.62477 1.000 49.29919  ? 57  CYS A CB  1 
ATOM   439  S SG  . CYS A 1 57 ? -4.68800  -15.80634 14.55702 1.000 52.47579  ? 57  CYS A SG  1 
ATOM   440  N N   . ASN A 1 58 ? -5.51903  -20.43298 12.78010 1.000 46.83896  ? 58  ASN A N   1 
ATOM   441  C CA  . ASN A 1 58 ? -5.47225  -21.57092 11.87083 1.000 48.22717  ? 58  ASN A CA  1 
ATOM   442  C C   . ASN A 1 58 ? -4.16432  -21.58062 11.06259 1.000 57.35567  ? 58  ASN A C   1 
ATOM   443  O O   . ASN A 1 58 ? -4.15213  -21.77766 9.84086  1.000 55.13563  ? 58  ASN A O   1 
ATOM   444  C CB  . ASN A 1 58 ? -6.71209  -21.55645 10.96730 1.000 45.00870  ? 58  ASN A CB  1 
ATOM   445  C CG  . ASN A 1 58 ? -6.82157  -22.78693 10.10400 1.000 54.66696  ? 58  ASN A CG  1 
ATOM   446  O OD1 . ASN A 1 58 ? -6.29492  -23.85600 10.44488 1.000 54.02158  ? 58  ASN A OD1 1 
ATOM   447  N ND2 . ASN A 1 58 ? -7.50612  -22.64798 8.96745  1.000 52.63431  ? 58  ASN A ND2 1 
ATOM   448  N N   . ALA A 1 59 ? -3.03914  -21.40810 11.77305 1.000 54.24062  ? 59  ALA A N   1 
ATOM   449  C CA  . ALA A 1 59 ? -1.75491  -21.17334 11.10650 1.000 57.59130  ? 59  ALA A CA  1 
ATOM   450  C C   . ALA A 1 59 ? -1.29547  -22.36160 10.25254 1.000 59.79472  ? 59  ALA A C   1 
ATOM   451  O O   . ALA A 1 59 ? -0.57855  -22.16841 9.26233  1.000 55.13663  ? 59  ALA A O   1 
ATOM   452  C CB  . ALA A 1 59 ? -0.69104  -20.83024 12.15582 1.000 51.89126  ? 59  ALA A CB  1 
ATOM   453  N N   . ALA A 1 60 ? -1.68368  -23.58364 10.62144 1.000 56.96960  ? 60  ALA A N   1 
ATOM   454  C CA  . ALA A 1 60 ? -1.21014  -24.82521 9.98734  1.000 61.17382  ? 60  ALA A CA  1 
ATOM   455  C C   . ALA A 1 60 ? -1.34890  -24.88244 8.46293  1.000 62.34134  ? 60  ALA A C   1 
ATOM   456  O O   . ALA A 1 60 ? -2.03363  -24.06508 7.86091  1.000 66.25500  ? 60  ALA A O   1 
ATOM   457  C CB  . ALA A 1 60 ? -1.94017  -26.01578 10.60149 1.000 61.74949  ? 60  ALA A CB  1 
ATOM   458  N N   . ALA B 2 1  ? -2.87670  -23.70791 5.54811  1.000 71.73780  ? 61  ALA B N   1 
ATOM   459  C CA  . ALA B 2 1  ? -3.41288  -22.35638 5.55229  1.000 72.06041  ? 61  ALA B CA  1 
ATOM   460  C C   . ALA B 2 1  ? -2.27605  -21.34680 5.39597  1.000 73.58064  ? 61  ALA B C   1 
ATOM   461  O O   . ALA B 2 1  ? -2.07556  -20.83074 4.29160  1.000 84.56772  ? 61  ALA B O   1 
ATOM   462  C CB  . ALA B 2 1  ? -4.21320  -22.09993 6.81189  1.000 69.16921  ? 61  ALA B CB  1 
ATOM   463  N N   . PHE B 2 2  ? -1.52854  -21.05106 6.46406  1.000 65.37028  ? 62  PHE B N   1 
ATOM   464  C CA  . PHE B 2 2  ? -0.37722  -20.16666 6.30399  1.000 64.97042  ? 62  PHE B CA  1 
ATOM   465  C C   . PHE B 2 2  ? 0.87033   -20.89974 5.91685  1.000 63.48255  ? 62  PHE B C   1 
ATOM   466  O O   . PHE B 2 2  ? 1.84156   -20.24206 5.54539  1.000 64.45648  ? 62  PHE B O   1 
ATOM   467  C CB  . PHE B 2 2  ? 0.13709   -19.47030 7.57049  1.000 65.52000  ? 62  PHE B CB  1 
ATOM   468  C CG  . PHE B 2 2  ? -0.83887  -18.71828 8.34710  1.000 66.74642  ? 62  PHE B CG  1 
ATOM   469  C CD1 . PHE B 2 2  ? -2.17084  -18.64516 7.99423  1.000 66.65790  ? 62  PHE B CD1 1 
ATOM   470  C CD2 . PHE B 2 2  ? -0.40028  -18.08444 9.50062  1.000 63.77012  ? 62  PHE B CD2 1 
ATOM   471  C CE1 . PHE B 2 2  ? -3.03100  -17.94996 8.77179  1.000 65.61309  ? 62  PHE B CE1 1 
ATOM   472  C CE2 . PHE B 2 2  ? -1.26117  -17.38842 10.26875 1.000 60.66442  ? 62  PHE B CE2 1 
ATOM   473  C CZ  . PHE B 2 2  ? -2.58553  -17.32588 9.91665  1.000 63.14415  ? 62  PHE B CZ  1 
ATOM   474  N N   . ARG B 2 3  ? 0.92474   -22.20671 6.16029  1.000 58.20911  ? 63  ARG B N   1 
ATOM   475  C CA  . ARG B 2 3  ? 2.22344   -22.84819 6.26937  1.000 59.81951  ? 63  ARG B CA  1 
ATOM   476  C C   . ARG B 2 3  ? 3.12073   -22.50402 5.08928  1.000 67.36193  ? 63  ARG B C   1 
ATOM   477  O O   . ARG B 2 3  ? 4.28904   -22.14704 5.27754  1.000 62.43091  ? 63  ARG B O   1 
ATOM   478  C CB  . ARG B 2 3  ? 2.07117   -24.34622 6.39473  1.000 62.08020  ? 63  ARG B CB  1 
ATOM   479  C CG  . ARG B 2 3  ? 3.38145   -24.92365 6.76081  1.000 69.31034  ? 63  ARG B CG  1 
ATOM   480  C CD  . ARG B 2 3  ? 3.61188   -26.21481 6.08054  1.000 75.22084  ? 63  ARG B CD  1 
ATOM   481  N NE  . ARG B 2 3  ? 4.90683   -26.73677 6.47788  1.000 74.96431  ? 63  ARG B NE  1 
ATOM   482  C CZ  . ARG B 2 3  ? 5.15485   -27.25978 7.66564  1.000 75.31308  ? 63  ARG B CZ  1 
ATOM   483  N NH1 . ARG B 2 3  ? 4.21495   -27.33366 8.59607  1.000 73.20506  ? 63  ARG B NH1 1 
ATOM   484  N NH2 . ARG B 2 3  ? 6.37680   -27.71630 7.92755  1.000 78.05707  ? 63  ARG B NH2 1 
ATOM   485  N N   . ASP B 2 4  ? 2.57083   -22.52735 3.86818  1.000 67.74094  ? 64  ASP B N   1 
ATOM   486  C CA  . ASP B 2 4  ? 3.37820   -22.18762 2.70072  1.000 65.20266  ? 64  ASP B CA  1 
ATOM   487  C C   . ASP B 2 4  ? 3.58732   -20.68000 2.56058  1.000 64.47749  ? 64  ASP B C   1 
ATOM   488  O O   . ASP B 2 4  ? 4.64080   -20.25722 2.07518  1.000 67.38573  ? 64  ASP B O   1 
ATOM   489  C CB  . ASP B 2 4  ? 2.74678   -22.78219 1.43972  1.000 64.49411  ? 64  ASP B CB  1 
ATOM   490  C CG  . ASP B 2 4  ? 2.50775   -24.29533 1.55846  1.000 72.62905  ? 64  ASP B CG  1 
ATOM   491  O OD1 . ASP B 2 4  ? 1.39118   -24.75062 1.20418  1.000 71.46949  ? 64  ASP B OD1 1 
ATOM   492  O OD2 . ASP B 2 4  ? 3.41959   -25.02770 2.02374  1.000 69.32895  ? 64  ASP B OD2 1 
ATOM   493  N N   . ASP B 2 5  ? 2.61521   -19.85504 2.97117  1.000 64.23536  ? 65  ASP B N   1 
ATOM   494  C CA  . ASP B 2 5  ? 2.88727   -18.42734 3.15828  1.000 65.87995  ? 65  ASP B CA  1 
ATOM   495  C C   . ASP B 2 5  ? 4.12683   -18.21377 4.01903  1.000 66.83155  ? 65  ASP B C   1 
ATOM   496  O O   . ASP B 2 5  ? 4.93837   -17.32287 3.74627  1.000 68.64727  ? 65  ASP B O   1 
ATOM   497  C CB  . ASP B 2 5  ? 1.70582   -17.71805 3.83600  1.000 72.19211  ? 65  ASP B CB  1 
ATOM   498  C CG  . ASP B 2 5  ? 0.52749   -17.49123 2.91532  1.000 79.97356  ? 65  ASP B CG  1 
ATOM   499  O OD1 . ASP B 2 5  ? 0.12883   -18.43720 2.19316  1.000 73.72571  ? 65  ASP B OD1 1 
ATOM   500  O OD2 . ASP B 2 5  ? -0.02408  -16.36296 2.95602  1.000 83.98041  ? 65  ASP B OD2 1 
ATOM   501  N N   . ILE B 2 6  ? 4.26684   -19.00638 5.08755  1.000 64.98625  ? 66  ILE B N   1 
ATOM   502  C CA  . ILE B 2 6  ? 5.35429   -18.80382 6.04032  1.000 67.81355  ? 66  ILE B CA  1 
ATOM   503  C C   . ILE B 2 6  ? 6.68646   -19.19671 5.41601  1.000 62.32159  ? 66  ILE B C   1 
ATOM   504  O O   . ILE B 2 6  ? 7.64779   -18.42044 5.43107  1.000 59.95560  ? 66  ILE B O   1 
ATOM   505  C CB  . ILE B 2 6  ? 5.09586   -19.59372 7.33794  1.000 62.72590  ? 66  ILE B CB  1 
ATOM   506  C CG1 . ILE B 2 6  ? 3.86136   -19.07420 8.07541  1.000 62.18633  ? 66  ILE B CG1 1 
ATOM   507  C CG2 . ILE B 2 6  ? 6.31352   -19.54504 8.23939  1.000 60.77833  ? 66  ILE B CG2 1 
ATOM   508  C CD1 . ILE B 2 6  ? 3.45149   -19.96651 9.24038  1.000 55.18083  ? 66  ILE B CD1 1 
ATOM   509  N N   . ILE B 2 7  ? 6.76995   -20.41836 4.87863  1.000 64.68912  ? 67  ILE B N   1 
ATOM   510  C CA  . ILE B 2 7  ? 7.99167   -20.83919 4.19338  1.000 65.79563  ? 67  ILE B CA  1 
ATOM   511  C C   . ILE B 2 7  ? 8.35748   -19.83949 3.10794  1.000 64.10180  ? 67  ILE B C   1 
ATOM   512  O O   . ILE B 2 7  ? 9.51617   -19.42544 2.99455  1.000 69.63179  ? 67  ILE B O   1 
ATOM   513  C CB  . ILE B 2 7  ? 7.83525   -22.26384 3.63243  1.000 67.21205  ? 67  ILE B CB  1 
ATOM   514  C CG1 . ILE B 2 7  ? 7.44821   -23.22449 4.75887  1.000 67.78513  ? 67  ILE B CG1 1 
ATOM   515  C CG2 . ILE B 2 7  ? 9.13655   -22.73163 3.02357  1.000 63.28772  ? 67  ILE B CG2 1 
ATOM   516  C CD1 . ILE B 2 7  ? 7.04082   -24.60181 4.28019  1.000 70.84129  ? 67  ILE B CD1 1 
ATOM   517  N N   . ALA B 2 8  ? 7.36237   -19.37330 2.34749  1.000 65.25909  ? 68  ALA B N   1 
ATOM   518  C CA  . ALA B 2 8  ? 7.64489   -18.49142 1.21762  1.000 64.74827  ? 68  ALA B CA  1 
ATOM   519  C C   . ALA B 2 8  ? 8.24569   -17.17254 1.67917  1.000 67.82182  ? 68  ALA B C   1 
ATOM   520  O O   . ALA B 2 8  ? 9.07709   -16.58232 0.97886  1.000 64.20642  ? 68  ALA B O   1 
ATOM   521  C CB  . ALA B 2 8  ? 6.37027   -18.24340 0.40456  1.000 62.93438  ? 68  ALA B CB  1 
ATOM   522  N N   . GLY B 2 9  ? 7.84541   -16.69613 2.86258  1.000 70.16722  ? 69  GLY B N   1 
ATOM   523  C CA  . GLY B 2 9  ? 8.40245   -15.46506 3.40966  1.000 65.59780  ? 69  GLY B CA  1 
ATOM   524  C C   . GLY B 2 9  ? 9.85000   -15.58019 3.85360  1.000 62.63109  ? 69  GLY B C   1 
ATOM   525  O O   . GLY B 2 9  ? 10.50879  -14.55572 4.07335  1.000 61.65718  ? 69  GLY B O   1 
ATOM   526  N N   . PHE B 2 10 ? 10.36032  -16.80402 3.98559  1.000 63.21779  ? 70  PHE B N   1 
ATOM   527  C CA  . PHE B 2 10 ? 11.75852  -16.98853 4.36354  1.000 63.16967  ? 70  PHE B CA  1 
ATOM   528  C C   . PHE B 2 10 ? 12.70269  -16.54152 3.24954  1.000 66.13382  ? 70  PHE B C   1 
ATOM   529  O O   . PHE B 2 10 ? 13.70225  -15.86247 3.50803  1.000 66.25371  ? 70  PHE B O   1 
ATOM   530  C CB  . PHE B 2 10 ? 11.99700  -18.44952 4.72750  1.000 58.76970  ? 70  PHE B CB  1 
ATOM   531  C CG  . PHE B 2 10 ? 11.26996  -18.88573 5.97128  1.000 63.47744  ? 70  PHE B CG  1 
ATOM   532  C CD1 . PHE B 2 10 ? 10.90416  -17.95571 6.93130  1.000 59.60647  ? 70  PHE B CD1 1 
ATOM   533  C CD2 . PHE B 2 10 ? 10.94830  -20.21829 6.18107  1.000 61.26671  ? 70  PHE B CD2 1 
ATOM   534  C CE1 . PHE B 2 10 ? 10.24174  -18.33766 8.07983  1.000 58.41709  ? 70  PHE B CE1 1 
ATOM   535  C CE2 . PHE B 2 10 ? 10.28434  -20.60978 7.33443  1.000 61.80915  ? 70  PHE B CE2 1 
ATOM   536  C CZ  . PHE B 2 10 ? 9.93212   -19.66198 8.28949  1.000 59.64359  ? 70  PHE B CZ  1 
ATOM   537  N N   . ALA B 2 11 ? 12.38551  -16.88459 2.00052  1.000 65.03039  ? 71  ALA B N   1 
ATOM   538  C CA  . ALA B 2 11 ? 13.27451  -16.57059 0.88874  1.000 67.32393  ? 71  ALA B CA  1 
ATOM   539  C C   . ALA B 2 11 ? 13.46891  -15.07422 0.68179  1.000 70.08771  ? 71  ALA B C   1 
ATOM   540  O O   . ALA B 2 11 ? 14.45095  -14.66916 0.05373  1.000 75.15293  ? 71  ALA B O   1 
ATOM   541  C CB  . ALA B 2 11 ? 12.73683  -17.19619 -0.39592 1.000 64.34428  ? 71  ALA B CB  1 
ATOM   542  N N   . ASN B 2 12 ? 12.57812  -14.23851 1.20085  1.000 67.65122  ? 72  ASN B N   1 
ATOM   543  C CA  . ASN B 2 12 ? 12.56256  -12.84147 0.80061  1.000 65.62123  ? 72  ASN B CA  1 
ATOM   544  C C   . ASN B 2 12 ? 13.19899  -11.89085 1.80200  1.000 65.81515  ? 72  ASN B C   1 
ATOM   545  O O   . ASN B 2 12 ? 13.40212  -10.71863 1.46755  1.000 66.22587  ? 72  ASN B O   1 
ATOM   546  C CB  . ASN B 2 12 ? 11.12391  -12.39615 0.54305  1.000 68.07042  ? 72  ASN B CB  1 
ATOM   547  C CG  . ASN B 2 12 ? 10.31809  -13.45652 -0.17412 1.000 78.07026  ? 72  ASN B CG  1 
ATOM   548  O OD1 . ASN B 2 12 ? 9.37833   -14.01974 0.39876  1.000 82.69361  ? 72  ASN B OD1 1 
ATOM   549  N ND2 . ASN B 2 12 ? 10.68485  -13.75019 -1.42770 1.000 72.30416  ? 72  ASN B ND2 1 
ATOM   550  N N   . THR B 2 13 ? 13.51854  -12.33534 3.01030  1.000 64.23848  ? 73  THR B N   1 
ATOM   551  C CA  . THR B 2 13 ? 13.95991  -11.38588 4.01684  1.000 61.62793  ? 73  THR B CA  1 
ATOM   552  C C   . THR B 2 13 ? 15.19667  -11.90665 4.73528  1.000 57.80713  ? 73  THR B C   1 
ATOM   553  O O   . THR B 2 13 ? 15.34594  -13.10764 4.97860  1.000 57.08322  ? 73  THR B O   1 
ATOM   554  C CB  . THR B 2 13 ? 12.80793  -11.07392 4.99644  1.000 62.13894  ? 73  THR B CB  1 
ATOM   555  O OG1 . THR B 2 13 ? 11.64883  -10.68805 4.24484  1.000 64.99768  ? 73  THR B OG1 1 
ATOM   556  C CG2 . THR B 2 13 ? 13.15913  -9.92425  5.90377  1.000 58.80682  ? 73  THR B CG2 1 
ATOM   557  N N   . ARG B 2 14 ? 16.10319  -10.99034 5.03622  1.000 55.33629  ? 74  ARG B N   1 
ATOM   558  C CA  . ARG B 2 14 ? 17.29097  -11.28443 5.81861  1.000 56.34046  ? 74  ARG B CA  1 
ATOM   559  C C   . ARG B 2 14 ? 17.20949  -10.44147 7.08403  1.000 57.97264  ? 74  ARG B C   1 
ATOM   560  O O   . ARG B 2 14 ? 17.18789  -9.20853  7.00604  1.000 54.01128  ? 74  ARG B O   1 
ATOM   561  C CB  . ARG B 2 14 ? 18.56300  -10.98765 5.01532  1.000 55.28937  ? 74  ARG B CB  1 
ATOM   562  C CG  . ARG B 2 14 ? 18.56724  -11.62064 3.61722  1.000 56.69179  ? 74  ARG B CG  1 
ATOM   563  C CD  . ARG B 2 14 ? 19.89158  -11.38693 2.86381  1.000 57.38680  ? 74  ARG B CD  1 
ATOM   564  N NE  . ARG B 2 14 ? 21.01442  -11.98534 3.57802  1.000 58.09618  ? 74  ARG B NE  1 
ATOM   565  C CZ  . ARG B 2 14 ? 21.30532  -13.28064 3.58588  1.000 54.26747  ? 74  ARG B CZ  1 
ATOM   566  N NH1 . ARG B 2 14 ? 20.61548  -14.15068 2.87414  1.000 52.30138  ? 74  ARG B NH1 1 
ATOM   567  N NH2 . ARG B 2 14 ? 22.31306  -13.71533 4.33659  1.000 57.64217  ? 74  ARG B NH2 1 
ATOM   568  N N   . TRP B 2 15 ? 17.12226  -11.10075 8.24304  1.000 51.85401  ? 75  TRP B N   1 
ATOM   569  C CA  . TRP B 2 15 ? 16.88401  -10.39337 9.49670  1.000 52.72703  ? 75  TRP B CA  1 
ATOM   570  C C   . TRP B 2 15 ? 18.19993  -9.95439  10.11930 1.000 50.58521  ? 75  TRP B C   1 
ATOM   571  O O   . TRP B 2 15 ? 19.18241  -10.70046 10.11501 1.000 52.72043  ? 75  TRP B O   1 
ATOM   572  C CB  . TRP B 2 15 ? 16.10828  -11.27110 10.47414 1.000 50.97769  ? 75  TRP B CB  1 
ATOM   573  C CG  . TRP B 2 15 ? 14.74961  -11.61314 9.97906  1.000 51.35375  ? 75  TRP B CG  1 
ATOM   574  C CD1 . TRP B 2 15 ? 14.35092  -12.79167 9.42103  1.000 49.04181  ? 75  TRP B CD1 1 
ATOM   575  C CD2 . TRP B 2 15 ? 13.60473  -10.74978 9.96921  1.000 45.12988  ? 75  TRP B CD2 1 
ATOM   576  N NE1 . TRP B 2 15 ? 13.02190  -12.71548 9.07858  1.000 50.53696  ? 75  TRP B NE1 1 
ATOM   577  C CE2 . TRP B 2 15 ? 12.54693  -11.46967 9.40248  1.000 42.69716  ? 75  TRP B CE2 1 
ATOM   578  C CE3 . TRP B 2 15 ? 13.37716  -9.43558  10.39570 1.000 50.02827  ? 75  TRP B CE3 1 
ATOM   579  C CZ2 . TRP B 2 15 ? 11.27062  -10.92721 9.25521  1.000 48.64404  ? 75  TRP B CZ2 1 
ATOM   580  C CZ3 . TRP B 2 15 ? 12.11157  -8.89159  10.23932 1.000 48.99909  ? 75  TRP B CZ3 1 
ATOM   581  C CH2 . TRP B 2 15 ? 11.07545  -9.63716  9.67475  1.000 47.11730  ? 75  TRP B CH2 1 
ATOM   582  N N   . LEU B 2 16 ? 18.20606  -8.74288  10.67362 1.000 49.24544  ? 76  LEU B N   1 
ATOM   583  C CA  . LEU B 2 16 ? 19.43562  -8.12238  11.13238 1.000 53.88685  ? 76  LEU B CA  1 
ATOM   584  C C   . LEU B 2 16 ? 19.42969  -7.71238  12.60102 1.000 57.37446  ? 76  LEU B C   1 
ATOM   585  O O   . LEU B 2 16 ? 20.46480  -7.23130  13.08937 1.000 52.45902  ? 76  LEU B O   1 
ATOM   586  C CB  . LEU B 2 16 ? 19.75106  -6.89944  10.26093 1.000 51.65378  ? 76  LEU B CB  1 
ATOM   587  C CG  . LEU B 2 16 ? 19.74872  -7.19881  8.75317  1.000 53.71682  ? 76  LEU B CG  1 
ATOM   588  C CD1 . LEU B 2 16 ? 20.08002  -5.95347  7.92217  1.000 49.08519  ? 76  LEU B CD1 1 
ATOM   589  C CD2 . LEU B 2 16 ? 20.69289  -8.35071  8.41161  1.000 48.77848  ? 76  LEU B CD2 1 
ATOM   590  N N   . GLY B 2 17 ? 18.32271  -7.87549  13.31999 1.000 51.84916  ? 77  GLY B N   1 
ATOM   591  C CA  . GLY B 2 17 ? 18.34491  -7.60687  14.74516 1.000 54.04678  ? 77  GLY B CA  1 
ATOM   592  C C   . GLY B 2 17 ? 16.98027  -7.28164  15.30622 1.000 55.37420  ? 77  GLY B C   1 
ATOM   593  O O   . GLY B 2 17 ? 16.05557  -6.87716  14.59790 1.000 53.47354  ? 77  GLY B O   1 
ATOM   594  N N   . LEU B 2 18 ? 16.87359  -7.45321  16.62383 1.000 54.78545  ? 78  LEU B N   1 
ATOM   595  C CA  . LEU B 2 18 ? 15.64359  -7.26873  17.38182 1.000 51.94444  ? 78  LEU B CA  1 
ATOM   596  C C   . LEU B 2 18 ? 15.92820  -6.42314  18.61169 1.000 50.55758  ? 78  LEU B C   1 
ATOM   597  O O   . LEU B 2 18 ? 16.80349  -6.75809  19.41479 1.000 50.73973  ? 78  LEU B O   1 
ATOM   598  C CB  . LEU B 2 18 ? 15.04853  -8.60920  17.80623 1.000 52.51727  ? 78  LEU B CB  1 
ATOM   599  C CG  . LEU B 2 18 ? 13.77188  -8.49609  18.65749 1.000 54.66234  ? 78  LEU B CG  1 
ATOM   600  C CD1 . LEU B 2 18 ? 12.61364  -7.94118  17.82640 1.000 50.55870  ? 78  LEU B CD1 1 
ATOM   601  C CD2 . LEU B 2 18 ? 13.39772  -9.82898  19.29547 1.000 46.46026  ? 78  LEU B CD2 1 
ATOM   602  N N   . THR B 2 19 ? 15.18461  -5.33395  18.75975 1.000 52.91422  ? 79  THR B N   1 
ATOM   603  C CA  . THR B 2 19 ? 15.28965  -4.45748  19.91921 1.000 55.20366  ? 79  THR B CA  1 
ATOM   604  C C   . THR B 2 19 ? 13.91170  -4.31997  20.55309 1.000 50.77818  ? 79  THR B C   1 
ATOM   605  O O   . THR B 2 19 ? 12.97217  -3.83607  19.91427 1.000 52.22666  ? 79  THR B O   1 
ATOM   606  C CB  . THR B 2 19 ? 15.84024  -3.08696  19.50979 1.000 57.00170  ? 79  THR B CB  1 
ATOM   607  O OG1 . THR B 2 19 ? 17.00368  -3.28144  18.70343 1.000 64.09164  ? 79  THR B OG1 1 
ATOM   608  C CG2 . THR B 2 19 ? 16.21644  -2.26474  20.72160 1.000 57.11208  ? 79  THR B CG2 1 
ATOM   609  N N   . ILE B 2 20 ? 13.78554  -4.73296  21.79891 1.000 55.05221  ? 80  ILE B N   1 
ATOM   610  C CA  . ILE B 2 20 ? 12.52526  -4.62024  22.51949 1.000 48.72886  ? 80  ILE B CA  1 
ATOM   611  C C   . ILE B 2 20 ? 12.59715  -3.37422  23.38318 1.000 46.80740  ? 80  ILE B C   1 
ATOM   612  O O   . ILE B 2 20 ? 13.58064  -3.16064  24.10099 1.000 47.27819  ? 80  ILE B O   1 
ATOM   613  C CB  . ILE B 2 20 ? 12.25070  -5.89484  23.32562 1.000 46.89046  ? 80  ILE B CB  1 
ATOM   614  C CG1 . ILE B 2 20 ? 11.83123  -6.99703  22.34045 1.000 45.01092  ? 80  ILE B CG1 1 
ATOM   615  C CG2 . ILE B 2 20 ? 11.20501  -5.64883  24.39846 1.000 45.52858  ? 80  ILE B CG2 1 
ATOM   616  C CD1 . ILE B 2 20 ? 11.64024  -8.38144  22.94914 1.000 47.53519  ? 80  ILE B CD1 1 
ATOM   617  N N   . PHE B 2 21 ? 11.60539  -2.50123  23.25505 1.000 48.39536  ? 81  PHE B N   1 
ATOM   618  C CA  . PHE B 2 21 ? 11.64330  -1.25372  23.99633 1.000 50.26920  ? 81  PHE B CA  1 
ATOM   619  C C   . PHE B 2 21 ? 10.41641  -1.01872  24.86015 1.000 45.86361  ? 81  PHE B C   1 
ATOM   620  O O   . PHE B 2 21 ? 10.35236  0.02123   25.50933 1.000 46.04135  ? 81  PHE B O   1 
ATOM   621  C CB  . PHE B 2 21 ? 11.85782  -0.05621  23.04782 1.000 52.76201  ? 81  PHE B CB  1 
ATOM   622  C CG  . PHE B 2 21 ? 10.79459  0.10581   21.98415 1.000 53.61910  ? 81  PHE B CG  1 
ATOM   623  C CD1 . PHE B 2 21 ? 10.88292  -0.57208  20.78857 1.000 53.56178  ? 81  PHE B CD1 1 
ATOM   624  C CD2 . PHE B 2 21 ? 9.72543   0.96147   22.17793 1.000 53.65681  ? 81  PHE B CD2 1 
ATOM   625  C CE1 . PHE B 2 21 ? 9.91404   -0.40657  19.80771 1.000 59.09534  ? 81  PHE B CE1 1 
ATOM   626  C CE2 . PHE B 2 21 ? 8.75476   1.12841   21.20488 1.000 59.96789  ? 81  PHE B CE2 1 
ATOM   627  C CZ  . PHE B 2 21 ? 8.84672   0.44866   20.01851 1.000 56.95923  ? 81  PHE B CZ  1 
ATOM   628  N N   . GLU B 2 22 ? 9.45238   -1.94020  24.88455 1.000 44.47581  ? 82  GLU B N   1 
ATOM   629  C CA  . GLU B 2 22 ? 8.31635   -1.87371  25.80020 1.000 46.10568  ? 82  GLU B CA  1 
ATOM   630  C C   . GLU B 2 22 ? 7.68986   -3.26002  25.91296 1.000 48.52236  ? 82  GLU B C   1 
ATOM   631  O O   . GLU B 2 22 ? 7.65612   -4.02030  24.93917 1.000 45.28508  ? 82  GLU B O   1 
ATOM   632  C CB  . GLU B 2 22 ? 7.26432   -0.85361  25.34875 1.000 45.51722  ? 82  GLU B CB  1 
ATOM   633  C CG  . GLU B 2 22 ? 6.01986   -0.75766  26.25398 1.000 47.16417  ? 82  GLU B CG  1 
ATOM   634  C CD  . GLU B 2 22 ? 4.85766   -1.66927  25.81028 1.000 50.54371  ? 82  GLU B CD  1 
ATOM   635  O OE1 . GLU B 2 22 ? 4.90902   -2.25644  24.70345 1.000 46.73884  ? 82  GLU B OE1 1 
ATOM   636  O OE2 . GLU B 2 22 ? 3.88657   -1.80962  26.57805 1.000 49.64908  ? 82  GLU B OE2 1 
ATOM   637  N N   . HIS B 2 23 ? 7.16658   -3.55937  27.10692 1.000 45.98211  ? 83  HIS B N   1 
ATOM   638  C CA  . HIS B 2 23 ? 6.60136   -4.86817  27.42153 1.000 46.32295  ? 83  HIS B CA  1 
ATOM   639  C C   . HIS B 2 23 ? 5.66321   -4.73273  28.61838 1.000 47.27459  ? 83  HIS B C   1 
ATOM   640  O O   . HIS B 2 23 ? 6.05162   -4.15845  29.63789 1.000 49.90514  ? 83  HIS B O   1 
ATOM   641  C CB  . HIS B 2 23 ? 7.73744   -5.86610  27.71830 1.000 46.90273  ? 83  HIS B CB  1 
ATOM   642  C CG  . HIS B 2 23 ? 7.27242   -7.23092  28.12494 1.000 48.04467  ? 83  HIS B CG  1 
ATOM   643  N ND1 . HIS B 2 23 ? 7.92681   -7.98064  29.08287 1.000 46.17957  ? 83  HIS B ND1 1 
ATOM   644  C CD2 . HIS B 2 23 ? 6.23641   -7.99291  27.69657 1.000 42.44872  ? 83  HIS B CD2 1 
ATOM   645  C CE1 . HIS B 2 23 ? 7.31015   -9.13583  29.23242 1.000 43.70570  ? 83  HIS B CE1 1 
ATOM   646  N NE2 . HIS B 2 23 ? 6.28882   -9.17407  28.39262 1.000 46.56133  ? 83  HIS B NE2 1 
ATOM   647  N N   . THR B 2 24 ? 4.42055   -5.21892  28.48409 1.000 45.52155  ? 84  THR B N   1 
ATOM   648  C CA  . THR B 2 24 ? 3.47749   -5.30790  29.59662 1.000 48.73277  ? 84  THR B CA  1 
ATOM   649  C C   . THR B 2 24 ? 2.65145   -6.58033  29.47299 1.000 47.09227  ? 84  THR B C   1 
ATOM   650  O O   . THR B 2 24 ? 2.31157   -7.00659  28.36845 1.000 48.06495  ? 84  THR B O   1 
ATOM   651  C CB  . THR B 2 24 ? 2.48303   -4.13363  29.67614 1.000 52.71399  ? 84  THR B CB  1 
ATOM   652  O OG1 . THR B 2 24 ? 1.35234   -4.40674  28.83492 1.000 63.96262  ? 84  THR B OG1 1 
ATOM   653  C CG2 . THR B 2 24 ? 3.11077   -2.82821  29.24852 1.000 55.48615  ? 84  THR B CG2 1 
ATOM   654  N N   . TRP B 2 25 ? 2.32142   -7.17993  30.60492 1.000 42.91342  ? 85  TRP B N   1 
ATOM   655  C CA  . TRP B 2 25 ? 1.36971   -8.28126  30.61844 1.000 47.84124  ? 85  TRP B CA  1 
ATOM   656  C C   . TRP B 2 25 ? 0.74317   -8.33072  31.99467 1.000 45.96700  ? 85  TRP B C   1 
ATOM   657  O O   . TRP B 2 25 ? 1.21594   -7.68753  32.93491 1.000 45.49065  ? 85  TRP B O   1 
ATOM   658  C CB  . TRP B 2 25 ? 2.01383   -9.63409  30.28243 1.000 40.94886  ? 85  TRP B CB  1 
ATOM   659  C CG  . TRP B 2 25 ? 2.98864   -10.15186 31.32175 1.000 45.74795  ? 85  TRP B CG  1 
ATOM   660  C CD1 . TRP B 2 25 ? 4.32652   -9.86871  31.39784 1.000 48.88452  ? 85  TRP B CD1 1 
ATOM   661  C CD2 . TRP B 2 25 ? 2.70789   -11.04173 32.41959 1.000 46.24282  ? 85  TRP B CD2 1 
ATOM   662  N NE1 . TRP B 2 25 ? 4.89308   -10.52097 32.47122 1.000 47.38253  ? 85  TRP B NE1 1 
ATOM   663  C CE2 . TRP B 2 25 ? 3.92380   -11.24475 33.11535 1.000 46.20851  ? 85  TRP B CE2 1 
ATOM   664  C CE3 . TRP B 2 25 ? 1.55027   -11.68032 32.88437 1.000 45.42262  ? 85  TRP B CE3 1 
ATOM   665  C CZ2 . TRP B 2 25 ? 4.01669   -12.06287 34.23982 1.000 45.33692  ? 85  TRP B CZ2 1 
ATOM   666  C CZ3 . TRP B 2 25 ? 1.64766   -12.50009 34.00318 1.000 44.16385  ? 85  TRP B CZ3 1 
ATOM   667  C CH2 . TRP B 2 25 ? 2.87157   -12.68214 34.66449 1.000 47.27918  ? 85  TRP B CH2 1 
ATOM   668  N N   . SER B 2 26 ? -0.30066  -9.13908  32.11395 1.000 44.37416  ? 86  SER B N   1 
ATOM   669  C CA  . SER B 2 26 ? -1.01868  -9.22537  33.37516 1.000 50.99593  ? 86  SER B CA  1 
ATOM   670  C C   . SER B 2 26 ? -1.75023  -10.55426 33.42648 1.000 53.73047  ? 86  SER B C   1 
ATOM   671  O O   . SER B 2 26 ? -2.37815  -10.95934 32.44417 1.000 48.44654  ? 86  SER B O   1 
ATOM   672  C CB  . SER B 2 26 ? -2.00062  -8.05747  33.51519 1.000 52.52426  ? 86  SER B CB  1 
ATOM   673  O OG  . SER B 2 26 ? -3.10831  -8.42680  34.30763 1.000 61.72337  ? 86  SER B OG  1 
ATOM   674  N N   . GLU B 2 27 ? -1.67131  -11.22002 34.58036 1.000 52.55736  ? 87  GLU B N   1 
ATOM   675  C CA  . GLU B 2 27 ? -2.34796  -12.50475 34.74242 1.000 56.84064  ? 87  GLU B CA  1 
ATOM   676  C C   . GLU B 2 27 ? -3.85348  -12.36661 34.57691 1.000 57.14708  ? 87  GLU B C   1 
ATOM   677  O O   . GLU B 2 27 ? -4.50261  -13.23516 33.98769 1.000 59.36423  ? 87  GLU B O   1 
ATOM   678  C CB  . GLU B 2 27 ? -2.03337  -13.10140 36.11207 1.000 54.29171  ? 87  GLU B CB  1 
ATOM   679  C CG  . GLU B 2 27 ? -2.40972  -14.55760 36.21164 1.000 61.35906  ? 87  GLU B CG  1 
ATOM   680  C CD  . GLU B 2 27 ? -1.66167  -15.40676 35.19542 1.000 68.72692  ? 87  GLU B CD  1 
ATOM   681  O OE1 . GLU B 2 27 ? -0.45560  -15.66592 35.42017 1.000 66.56168  ? 87  GLU B OE1 1 
ATOM   682  O OE2 . GLU B 2 27 ? -2.26820  -15.78401 34.15833 1.000 70.24800  ? 87  GLU B OE2 1 
ATOM   683  N N   . ALA B 2 28 ? -4.42633  -11.27674 35.09016 1.000 59.26715  ? 88  ALA B N   1 
ATOM   684  C CA  . ALA B 2 28 ? -5.87503  -11.15094 35.13170 1.000 60.68005  ? 88  ALA B CA  1 
ATOM   685  C C   . ALA B 2 28 ? -6.45387  -10.89491 33.75146 1.000 62.86340  ? 88  ALA B C   1 
ATOM   686  O O   . ALA B 2 28 ? -7.63578  -11.17008 33.52073 1.000 66.08184  ? 88  ALA B O   1 
ATOM   687  C CB  . ALA B 2 28 ? -6.27650  -10.02730 36.09594 1.000 58.40943  ? 88  ALA B CB  1 
ATOM   688  N N   . GLU B 2 29 ? -5.64718  -10.37543 32.83775 1.000 55.36716  ? 89  GLU B N   1 
ATOM   689  C CA  . GLU B 2 29 ? -6.08372  -10.11509 31.48241 1.000 60.02651  ? 89  GLU B CA  1 
ATOM   690  C C   . GLU B 2 29 ? -5.81346  -11.27372 30.54485 1.000 56.74514  ? 89  GLU B C   1 
ATOM   691  O O   . GLU B 2 29 ? -6.46691  -11.36037 29.50080 1.000 49.77887  ? 89  GLU B O   1 
ATOM   692  C CB  . GLU B 2 29 ? -5.38110  -8.86735  30.95062 1.000 63.07640  ? 89  GLU B CB  1 
ATOM   693  C CG  . GLU B 2 29 ? -5.52234  -7.69190  31.88650 1.000 62.83568  ? 89  GLU B CG  1 
ATOM   694  C CD  . GLU B 2 29 ? -6.74401  -6.87492  31.55573 1.000 75.20898  ? 89  GLU B CD  1 
ATOM   695  O OE1 . GLU B 2 29 ? -6.62142  -5.94418  30.72203 1.000 82.66530  ? 89  GLU B OE1 1 
ATOM   696  O OE2 . GLU B 2 29 ? -7.82814  -7.17978  32.10574 1.000 72.70204  ? 89  GLU B OE2 1 
ATOM   697  N N   . ASN B 2 30 ? -4.87082  -12.15544 30.89545 1.000 54.41767  ? 90  ASN B N   1 
ATOM   698  C CA  . ASN B 2 30 ? -4.37500  -13.17219 29.97352 1.000 51.34624  ? 90  ASN B CA  1 
ATOM   699  C C   . ASN B 2 30 ? -3.95321  -12.52303 28.66085 1.000 52.15418  ? 90  ASN B C   1 
ATOM   700  O O   . ASN B 2 30 ? -4.19676  -13.04045 27.56793 1.000 51.30011  ? 90  ASN B O   1 
ATOM   701  C CB  . ASN B 2 30 ? -5.41944  -14.26473 29.75402 1.000 53.11263  ? 90  ASN B CB  1 
ATOM   702  C CG  . ASN B 2 30 ? -5.74661  -15.00956 31.03656 1.000 60.82288  ? 90  ASN B CG  1 
ATOM   703  O OD1 . ASN B 2 30 ? -4.93478  -15.79958 31.53922 1.000 57.96964  ? 90  ASN B OD1 1 
ATOM   704  N ND2 . ASN B 2 30 ? -6.93944  -14.75878 31.57923 1.000 58.95715  ? 90  ASN B ND2 1 
ATOM   705  N N   . THR B 2 31 ? -3.33384  -11.35230 28.77549 1.000 49.28380  ? 91  THR B N   1 
ATOM   706  C CA  . THR B 2 31 ? -2.94326  -10.57256 27.61618 1.000 50.47599  ? 91  THR B CA  1 
ATOM   707  C C   . THR B 2 31 ? -1.65689  -9.85077  27.96326 1.000 49.55424  ? 91  THR B C   1 
ATOM   708  O O   . THR B 2 31 ? -1.41739  -9.50868  29.12294 1.000 42.51808  ? 91  THR B O   1 
ATOM   709  C CB  . THR B 2 31 ? -4.02773  -9.55539  27.20767 1.000 51.73507  ? 91  THR B CB  1 
ATOM   710  O OG1 . THR B 2 31 ? -5.30726  -10.19511 27.23989 1.000 58.00241  ? 91  THR B OG1 1 
ATOM   711  C CG2 . THR B 2 31 ? -3.78998  -9.04954  25.80551 1.000 49.04816  ? 91  THR B CG2 1 
ATOM   712  N N   . GLY B 2 32 ? -0.82324  -9.64983  26.94988 1.000 46.72112  ? 92  GLY B N   1 
ATOM   713  C CA  . GLY B 2 32 ? 0.32383   -8.77508  27.08136 1.000 46.93515  ? 92  GLY B CA  1 
ATOM   714  C C   . GLY B 2 32 ? 0.75482   -8.29989  25.71211 1.000 44.68971  ? 92  GLY B C   1 
ATOM   715  O O   . GLY B 2 32 ? 0.29084   -8.79741  24.68909 1.000 45.20861  ? 92  GLY B O   1 
ATOM   716  N N   . TYR B 2 33 ? 1.68607   -7.34905  25.71284 1.000 47.28933  ? 93  TYR B N   1 
ATOM   717  C CA  . TYR B 2 33 ? 2.12774   -6.64801  24.51892 1.000 44.96389  ? 93  TYR B CA  1 
ATOM   718  C C   . TYR B 2 33 ? 3.64770   -6.55529  24.52709 1.000 47.12995  ? 93  TYR B C   1 
ATOM   719  O O   . TYR B 2 33 ? 4.27143   -6.49571  25.58874 1.000 42.32927  ? 93  TYR B O   1 
ATOM   720  C CB  . TYR B 2 33 ? 1.54682   -5.24403  24.46047 1.000 42.08845  ? 93  TYR B CB  1 
ATOM   721  C CG  . TYR B 2 33 ? 0.04532   -5.18204  24.47240 1.000 48.89343  ? 93  TYR B CG  1 
ATOM   722  C CD1 . TYR B 2 33 ? -0.67710  -5.33628  25.65898 1.000 47.12011  ? 93  TYR B CD1 1 
ATOM   723  C CD2 . TYR B 2 33 ? -0.66085  -4.90986  23.30052 1.000 47.63509  ? 93  TYR B CD2 1 
ATOM   724  C CE1 . TYR B 2 33 ? -2.07630  -5.26111  25.66513 1.000 51.23477  ? 93  TYR B CE1 1 
ATOM   725  C CE2 . TYR B 2 33 ? -2.04188  -4.82607  23.29898 1.000 43.81494  ? 93  TYR B CE2 1 
ATOM   726  C CZ  . TYR B 2 33 ? -2.74152  -5.01661  24.47186 1.000 51.98594  ? 93  TYR B CZ  1 
ATOM   727  O OH  . TYR B 2 33 ? -4.10588  -4.93257  24.45403 1.000 57.63415  ? 93  TYR B OH  1 
ATOM   728  N N   . VAL B 2 34 ? 4.24128   -6.51414  23.33375 1.000 45.28936  ? 94  VAL B N   1 
ATOM   729  C CA  . VAL B 2 34 ? 5.68786   -6.36905  23.17453 1.000 39.75699  ? 94  VAL B CA  1 
ATOM   730  C C   . VAL B 2 34 ? 5.90249   -5.40184  22.01974 1.000 45.03426  ? 94  VAL B C   1 
ATOM   731  O O   . VAL B 2 34 ? 5.50307   -5.69264  20.88591 1.000 46.17311  ? 94  VAL B O   1 
ATOM   732  C CB  . VAL B 2 34 ? 6.39433   -7.70745  22.89023 1.000 38.33381  ? 94  VAL B CB  1 
ATOM   733  C CG1 . VAL B 2 34 ? 7.88695   -7.50137  22.76253 1.000 43.23605  ? 94  VAL B CG1 1 
ATOM   734  C CG2 . VAL B 2 34 ? 6.11021   -8.73958  23.97218 1.000 39.98366  ? 94  VAL B CG2 1 
ATOM   735  N N   . SER B 2 35 ? 6.51106   -4.25455  22.29544 1.000 44.54367  ? 95  SER B N   1 
ATOM   736  C CA  . SER B 2 35 ? 6.87102   -3.29966  21.25687 1.000 48.88804  ? 95  SER B CA  1 
ATOM   737  C C   . SER B 2 35 ? 8.31334   -3.52410  20.84039 1.000 52.43322  ? 95  SER B C   1 
ATOM   738  O O   . SER B 2 35 ? 9.18696   -3.70236  21.69468 1.000 50.80208  ? 95  SER B O   1 
ATOM   739  C CB  . SER B 2 35 ? 6.70678   -1.86163  21.75263 1.000 50.65422  ? 95  SER B CB  1 
ATOM   740  O OG  . SER B 2 35 ? 5.35904   -1.57276  22.07369 1.000 49.47095  ? 95  SER B OG  1 
ATOM   741  N N   . PHE B 2 36 ? 8.57628   -3.48068  19.53228 1.000 50.34071  ? 96  PHE B N   1 
ATOM   742  C CA  . PHE B 2 36 ? 9.91582   -3.85471  19.09378 1.000 50.76770  ? 96  PHE B CA  1 
ATOM   743  C C   . PHE B 2 36 ? 10.26246  -3.24415  17.73375 1.000 55.80966  ? 96  PHE B C   1 
ATOM   744  O O   . PHE B 2 36 ? 9.38919   -2.87323  16.93675 1.000 54.41704  ? 96  PHE B O   1 
ATOM   745  C CB  . PHE B 2 36 ? 10.06555  -5.38432  19.05867 1.000 46.73315  ? 96  PHE B CB  1 
ATOM   746  C CG  . PHE B 2 36 ? 9.20782   -6.05773  18.01917 1.000 48.51154  ? 96  PHE B CG  1 
ATOM   747  C CD1 . PHE B 2 36 ? 7.94392   -6.53350  18.34226 1.000 48.30071  ? 96  PHE B CD1 1 
ATOM   748  C CD2 . PHE B 2 36 ? 9.66401   -6.20211  16.70804 1.000 48.81911  ? 96  PHE B CD2 1 
ATOM   749  C CE1 . PHE B 2 36 ? 7.13936   -7.14551  17.37347 1.000 51.62207  ? 96  PHE B CE1 1 
ATOM   750  C CE2 . PHE B 2 36 ? 8.87506   -6.81600  15.74103 1.000 48.37787  ? 96  PHE B CE2 1 
ATOM   751  C CZ  . PHE B 2 36 ? 7.61321   -7.28407  16.06313 1.000 48.53314  ? 96  PHE B CZ  1 
ATOM   752  N N   . ILE B 2 37 ? 11.56989  -3.13582  17.49543 1.000 51.93087  ? 97  ILE B N   1 
ATOM   753  C CA  . ILE B 2 37 ? 12.13782  -2.80356  16.19498 1.000 55.36629  ? 97  ILE B CA  1 
ATOM   754  C C   . ILE B 2 37 ? 12.84189  -4.04640  15.68543 1.000 53.30960  ? 97  ILE B C   1 
ATOM   755  O O   . ILE B 2 37 ? 13.74900  -4.56339  16.35133 1.000 54.36295  ? 97  ILE B O   1 
ATOM   756  C CB  . ILE B 2 37 ? 13.13161  -1.63383  16.26471 1.000 55.41922  ? 97  ILE B CB  1 
ATOM   757  C CG1 . ILE B 2 37 ? 12.58412  -0.50002  17.12221 1.000 63.60967  ? 97  ILE B CG1 1 
ATOM   758  C CG2 . ILE B 2 37 ? 13.45733  -1.14042  14.85113 1.000 62.57404  ? 97  ILE B CG2 1 
ATOM   759  C CD1 . ILE B 2 37 ? 13.61089  0.60030   17.35960 1.000 73.84646  ? 97  ILE B CD1 1 
ATOM   760  N N   . ALA B 2 38 ? 12.42635  -4.53234  14.51838 1.000 49.82334  ? 98  ALA B N   1 
ATOM   761  C CA  . ALA B 2 38 ? 13.06223  -5.67252  13.86615 1.000 48.34516  ? 98  ALA B CA  1 
ATOM   762  C C   . ALA B 2 38 ? 13.66018  -5.16992  12.56048 1.000 52.91475  ? 98  ALA B C   1 
ATOM   763  O O   . ALA B 2 38 ? 12.92778  -4.73137  11.66759 1.000 53.47421  ? 98  ALA B O   1 
ATOM   764  C CB  . ALA B 2 38 ? 12.06985  -6.80160  13.61541 1.000 42.89224  ? 98  ALA B CB  1 
ATOM   765  N N   . ARG B 2 39 ? 14.98546  -5.22170  12.45917 1.000 51.96824  ? 99  ARG B N   1 
ATOM   766  C CA  . ARG B 2 39 ? 15.69646  -4.73144  11.29441 1.000 52.24149  ? 99  ARG B CA  1 
ATOM   767  C C   . ARG B 2 39 ? 15.96150  -5.87651  10.32448 1.000 52.49485  ? 99  ARG B C   1 
ATOM   768  O O   . ARG B 2 39 ? 16.13192  -7.03651  10.71645 1.000 51.12419  ? 99  ARG B O   1 
ATOM   769  C CB  . ARG B 2 39 ? 16.98511  -4.03235  11.72113 1.000 57.23169  ? 99  ARG B CB  1 
ATOM   770  C CG  . ARG B 2 39 ? 16.72096  -2.64274  12.28050 1.000 57.38610  ? 99  ARG B CG  1 
ATOM   771  C CD  . ARG B 2 39 ? 17.86313  -2.10408  13.13712 1.000 62.49780  ? 99  ARG B CD  1 
ATOM   772  N NE  . ARG B 2 39 ? 18.27424  -3.03392  14.18874 1.000 69.82837  ? 99  ARG B NE  1 
ATOM   773  C CZ  . ARG B 2 39 ? 17.64872  -3.20974  15.35198 1.000 71.08415  ? 99  ARG B CZ  1 
ATOM   774  N NH1 . ARG B 2 39 ? 16.52831  -2.56715  15.64309 1.000 68.77825  ? 99  ARG B NH1 1 
ATOM   775  N NH2 . ARG B 2 39 ? 18.16504  -4.05021  16.24978 1.000 63.29051  ? 99  ARG B NH2 1 
ATOM   776  N N   . PHE B 2 40 ? 15.94375  -5.54921  9.03964  1.000 55.06483  ? 100 PHE B N   1 
ATOM   777  C CA  . PHE B 2 40 ? 15.96989  -6.56917  8.00487  1.000 55.29361  ? 100 PHE B CA  1 
ATOM   778  C C   . PHE B 2 40 ? 16.52593  -5.97020  6.72860  1.000 55.99867  ? 100 PHE B C   1 
ATOM   779  O O   . PHE B 2 40 ? 16.75325  -4.76265  6.62415  1.000 57.66478  ? 100 PHE B O   1 
ATOM   780  C CB  . PHE B 2 40 ? 14.57060  -7.10973  7.72110  1.000 55.96006  ? 100 PHE B CB  1 
ATOM   781  C CG  . PHE B 2 40 ? 13.63703  -6.06828  7.17475  1.000 55.62416  ? 100 PHE B CG  1 
ATOM   782  C CD1 . PHE B 2 40 ? 13.55702  -5.82856  5.80319  1.000 59.23892  ? 100 PHE B CD1 1 
ATOM   783  C CD2 . PHE B 2 40 ? 12.84825  -5.31144  8.03285  1.000 56.23625  ? 100 PHE B CD2 1 
ATOM   784  C CE1 . PHE B 2 40 ? 12.71477  -4.85832  5.29791  1.000 57.76668  ? 100 PHE B CE1 1 
ATOM   785  C CE2 . PHE B 2 40 ? 11.98573  -4.34284  7.53486  1.000 58.43334  ? 100 PHE B CE2 1 
ATOM   786  C CZ  . PHE B 2 40 ? 11.92012  -4.11706  6.16061  1.000 62.88095  ? 100 PHE B CZ  1 
ATOM   787  N N   . SER B 2 41 ? 16.68107  -6.82312  5.73198  1.000 55.46089  ? 101 SER B N   1 
ATOM   788  C CA  . SER B 2 41 ? 16.96798  -6.38480  4.38204  1.000 58.95912  ? 101 SER B CA  1 
ATOM   789  C C   . SER B 2 41 ? 16.17828  -7.28244  3.44893  1.000 61.56070  ? 101 SER B C   1 
ATOM   790  O O   . SER B 2 41 ? 15.96492  -8.46556  3.74337  1.000 59.12851  ? 101 SER B O   1 
ATOM   791  C CB  . SER B 2 41 ? 18.47072  -6.44006  4.05646  1.000 59.10481  ? 101 SER B CB  1 
ATOM   792  O OG  . SER B 2 41 ? 18.89573  -7.77221  3.79697  1.000 59.65369  ? 101 SER B OG  1 
ATOM   793  N N   . GLU B 2 42 ? 15.71289  -6.70163  2.34765  1.000 63.42156  ? 102 GLU B N   1 
ATOM   794  C CA  . GLU B 2 42 ? 14.98693  -7.44250  1.32737  1.000 67.23547  ? 102 GLU B CA  1 
ATOM   795  C C   . GLU B 2 42 ? 15.40993  -6.90635  -0.02860 1.000 64.57876  ? 102 GLU B C   1 
ATOM   796  O O   . GLU B 2 42 ? 15.39691  -5.69123  -0.25228 1.000 58.31906  ? 102 GLU B O   1 
ATOM   797  C CB  . GLU B 2 42 ? 13.46743  -7.32809  1.51552  1.000 69.99758  ? 102 GLU B CB  1 
ATOM   798  C CG  . GLU B 2 42 ? 12.98135  -5.91139  1.82017  1.000 73.11639  ? 102 GLU B CG  1 
ATOM   799  C CD  . GLU B 2 42 ? 11.48543  -5.73020  1.59197  1.000 82.71277  ? 102 GLU B CD  1 
ATOM   800  O OE1 . GLU B 2 42 ? 10.84709  -6.66010  1.04522  1.000 83.97663  ? 102 GLU B OE1 1 
ATOM   801  O OE2 . GLU B 2 42 ? 10.95453  -4.65183  1.95404  1.000 88.39449  ? 102 GLU B OE2 1 
ATOM   802  N N   . GLN B 2 43 ? 15.82480  -7.82023  -0.90492 1.000 67.92070  ? 103 GLN B N   1 
ATOM   803  C CA  . GLN B 2 43 ? 16.35723  -7.48103  -2.22814 1.000 70.96866  ? 103 GLN B CA  1 
ATOM   804  C C   . GLN B 2 43 ? 17.44589  -6.41124  -2.14268 1.000 71.40278  ? 103 GLN B C   1 
ATOM   805  O O   . GLN B 2 43 ? 17.53935  -5.51961  -2.99312 1.000 73.95217  ? 103 GLN B O   1 
ATOM   806  C CB  . GLN B 2 43 ? 15.23601  -7.04966  -3.18203 1.000 68.58554  ? 103 GLN B CB  1 
ATOM   807  C CG  . GLN B 2 43 ? 14.12395  -8.09514  -3.39090 1.000 74.70613  ? 103 GLN B CG  1 
ATOM   808  C CD  . GLN B 2 43 ? 14.63879  -9.44120  -3.88635 1.000 81.51898  ? 103 GLN B CD  1 
ATOM   809  O OE1 . GLN B 2 43 ? 14.58197  -9.74007  -5.08069 1.000 83.27841  ? 103 GLN B OE1 1 
ATOM   810  N NE2 . GLN B 2 43 ? 15.12552  -10.26920 -2.96164 1.000 86.81520  ? 103 GLN B NE2 1 
ATOM   811  N N   . GLY B 2 44 ? 18.27540  -6.49433  -1.09656 1.000 65.34310  ? 104 GLY B N   1 
ATOM   812  C CA  . GLY B 2 44 ? 19.41237  -5.61098  -0.93528 1.000 60.77890  ? 104 GLY B CA  1 
ATOM   813  C C   . GLY B 2 44 ? 19.14788  -4.29299  -0.23435 1.000 65.57294  ? 104 GLY B C   1 
ATOM   814  O O   . GLY B 2 44 ? 20.10252  -3.53649  -0.00724 1.000 68.17902  ? 104 GLY B O   1 
ATOM   815  N N   . LYS B 2 45 ? 17.90121  -3.98881  0.12657  1.000 65.11384  ? 105 LYS B N   1 
ATOM   816  C CA  . LYS B 2 45 ? 17.56102  -2.72842  0.78816  1.000 66.73207  ? 105 LYS B CA  1 
ATOM   817  C C   . LYS B 2 45 ? 17.28103  -2.94762  2.27248  1.000 63.55859  ? 105 LYS B C   1 
ATOM   818  O O   . LYS B 2 45 ? 16.51184  -3.84047  2.63297  1.000 63.54228  ? 105 LYS B O   1 
ATOM   819  C CB  . LYS B 2 45 ? 16.34258  -2.06557  0.13294  1.000 67.40386  ? 105 LYS B CB  1 
ATOM   820  C CG  . LYS B 2 45 ? 16.65372  -1.17798  -1.08467 1.000 75.95620  ? 105 LYS B CG  1 
ATOM   821  C CD  . LYS B 2 45 ? 18.13681  -0.78441  -1.14656 1.000 80.19230  ? 105 LYS B CD  1 
ATOM   822  C CE  . LYS B 2 45 ? 18.47166  0.36496   -0.20943 1.000 78.67268  ? 105 LYS B CE  1 
ATOM   823  N NZ  . LYS B 2 45 ? 19.95562  0.57828   -0.19331 1.000 84.38834  ? 105 LYS B NZ  1 
ATOM   824  N N   . ASN B 2 46 ? 17.89584  -2.11885  3.11956  1.000 60.99047  ? 106 ASN B N   1 
ATOM   825  C CA  . ASN B 2 46 ? 17.60606  -2.11072  4.54864  1.000 61.82740  ? 106 ASN B CA  1 
ATOM   826  C C   . ASN B 2 46 ? 16.24492  -1.47639  4.82888  1.000 64.51454  ? 106 ASN B C   1 
ATOM   827  O O   . ASN B 2 46 ? 15.80765  -0.56570  4.11754  1.000 67.45234  ? 106 ASN B O   1 
ATOM   828  C CB  . ASN B 2 46 ? 18.68217  -1.32622  5.31534  1.000 61.71398  ? 106 ASN B CB  1 
ATOM   829  C CG  . ASN B 2 46 ? 19.99735  -2.07219  5.43113  1.000 62.04756  ? 106 ASN B CG  1 
ATOM   830  O OD1 . ASN B 2 46 ? 20.15675  -3.16581  4.88864  1.000 62.18650  ? 106 ASN B OD1 1 
ATOM   831  N ND2 . ASN B 2 46 ? 20.95610  -1.47319  6.13531  1.000 61.48987  ? 106 ASN B ND2 1 
ATOM   832  N N   . GLY B 2 47 ? 15.58828  -1.95489  5.88616  1.000 60.14153  ? 107 GLY B N   1 
ATOM   833  C CA  . GLY B 2 47 ? 14.33917  -1.41146  6.39217  1.000 56.08333  ? 107 GLY B CA  1 
ATOM   834  C C   . GLY B 2 47 ? 14.15210  -1.89378  7.81576  1.000 61.99350  ? 107 GLY B C   1 
ATOM   835  O O   . GLY B 2 47 ? 14.92327  -2.71995  8.31303  1.000 55.73328  ? 107 GLY B O   1 
ATOM   836  N N   . ALA B 2 48 ? 13.10229  -1.37959  8.47150  1.000 61.25803  ? 108 ALA B N   1 
ATOM   837  C CA  . ALA B 2 48 ? 12.85690  -1.66738  9.88086  1.000 58.87854  ? 108 ALA B CA  1 
ATOM   838  C C   . ALA B 2 48 ? 11.36567  -1.74968  10.17906 1.000 61.71597  ? 108 ALA B C   1 
ATOM   839  O O   . ALA B 2 48 ? 10.59649  -0.86110  9.79547  1.000 62.58116  ? 108 ALA B O   1 
ATOM   840  C CB  . ALA B 2 48 ? 13.50265  -0.60611  10.77326 1.000 59.31694  ? 108 ALA B CB  1 
ATOM   841  N N   . ILE B 2 49 ? 10.96856  -2.81249  10.87158 1.000 54.69384  ? 109 ILE B N   1 
ATOM   842  C CA  . ILE B 2 49 ? 9.61273   -2.94986  11.38141 1.000 57.13944  ? 109 ILE B CA  1 
ATOM   843  C C   . ILE B 2 49 ? 9.55987   -2.35367  12.78081 1.000 59.51827  ? 109 ILE B C   1 
ATOM   844  O O   . ILE B 2 49 ? 10.37527  -2.69900  13.64224 1.000 57.90431  ? 109 ILE B O   1 
ATOM   845  C CB  . ILE B 2 49 ? 9.18881   -4.42427  11.41006 1.000 57.59274  ? 109 ILE B CB  1 
ATOM   846  C CG1 . ILE B 2 49 ? 8.96733   -4.95614  10.00493 1.000 56.90558  ? 109 ILE B CG1 1 
ATOM   847  C CG2 . ILE B 2 49 ? 7.93877   -4.61029  12.25808 1.000 57.71294  ? 109 ILE B CG2 1 
ATOM   848  C CD1 . ILE B 2 49 ? 8.81043   -6.45270  9.99909  1.000 57.33555  ? 109 ILE B CD1 1 
ATOM   849  N N   . ILE B 2 50 ? 8.61323   -1.45262  13.00773 1.000 52.51946  ? 110 ILE B N   1 
ATOM   850  C CA  . ILE B 2 50 ? 8.26113   -1.00050  14.33999 1.000 55.16371  ? 110 ILE B CA  1 
ATOM   851  C C   . ILE B 2 50 ? 6.82359   -1.42585  14.58537 1.000 54.94427  ? 110 ILE B C   1 
ATOM   852  O O   . ILE B 2 50 ? 5.93721   -1.12205  13.77992 1.000 58.78486  ? 110 ILE B O   1 
ATOM   853  C CB  . ILE B 2 50 ? 8.44985   0.51039   14.49542 1.000 61.64127  ? 110 ILE B CB  1 
ATOM   854  C CG1 . ILE B 2 50 ? 9.85825   0.86715   14.00404 1.000 62.46825  ? 110 ILE B CG1 1 
ATOM   855  C CG2 . ILE B 2 50 ? 8.23560   0.92029   15.95352 1.000 55.99845  ? 110 ILE B CG2 1 
ATOM   856  C CD1 . ILE B 2 50 ? 10.28433  2.27316   14.26355 1.000 77.89195  ? 110 ILE B CD1 1 
ATOM   857  N N   . GLU B 2 51 ? 6.60098   -2.15570  15.67935 1.000 52.26107  ? 111 GLU B N   1 
ATOM   858  C CA  . GLU B 2 51 ? 5.35477   -2.87975  15.88455 1.000 52.88588  ? 111 GLU B CA  1 
ATOM   859  C C   . GLU B 2 51 ? 5.16574   -3.15333  17.37294 1.000 53.21013  ? 111 GLU B C   1 
ATOM   860  O O   . GLU B 2 51 ? 6.13942   -3.30486  18.12096 1.000 52.85015  ? 111 GLU B O   1 
ATOM   861  C CB  . GLU B 2 51 ? 5.37192   -4.19281  15.08896 1.000 51.23560  ? 111 GLU B CB  1 
ATOM   862  C CG  . GLU B 2 51 ? 4.15019   -5.06838  15.25746 1.000 51.64582  ? 111 GLU B CG  1 
ATOM   863  C CD  . GLU B 2 51 ? 3.03666   -4.66919  14.30908 1.000 63.88546  ? 111 GLU B CD  1 
ATOM   864  O OE1 . GLU B 2 51 ? 3.23153   -3.68908  13.54919 1.000 63.46540  ? 111 GLU B OE1 1 
ATOM   865  O OE2 . GLU B 2 51 ? 1.97419   -5.34015  14.30507 1.000 62.94212  ? 111 GLU B OE2 1 
ATOM   866  N N   . ARG B 2 52 ? 3.90577   -3.20024  17.80002 1.000 56.04256  ? 112 ARG B N   1 
ATOM   867  C CA  . ARG B 2 52 ? 3.53120   -3.62013  19.15158 1.000 50.03526  ? 112 ARG B CA  1 
ATOM   868  C C   . ARG B 2 52 ? 2.65732   -4.85249  18.97848 1.000 50.19941  ? 112 ARG B C   1 
ATOM   869  O O   . ARG B 2 52 ? 1.47664   -4.73349  18.64590 1.000 49.99084  ? 112 ARG B O   1 
ATOM   870  C CB  . ARG B 2 52 ? 2.80201   -2.51702  19.92135 1.000 54.72309  ? 112 ARG B CB  1 
ATOM   871  C CG  . ARG B 2 52 ? 2.53409   -2.85934  21.40732 1.000 47.83119  ? 112 ARG B CG  1 
ATOM   872  C CD  . ARG B 2 52 ? 2.15109   -1.62697  22.22252 1.000 47.66295  ? 112 ARG B CD  1 
ATOM   873  N NE  . ARG B 2 52 ? 2.17891   -1.85719  23.67452 1.000 50.41561  ? 112 ARG B NE  1 
ATOM   874  C CZ  . ARG B 2 52 ? 1.11101   -1.86911  24.46584 1.000 46.98242  ? 112 ARG B CZ  1 
ATOM   875  N NH1 . ARG B 2 52 ? -0.11403  -1.75452  23.98110 1.000 51.71211  ? 112 ARG B NH1 1 
ATOM   876  N NH2 . ARG B 2 52 ? 1.27609   -1.98172  25.77816 1.000 51.20770  ? 112 ARG B NH2 1 
ATOM   877  N N   . SER B 2 53 ? 3.24113   -6.03487  19.15814 1.000 47.07658  ? 113 SER B N   1 
ATOM   878  C CA  . SER B 2 53 ? 2.48249   -7.25921  18.99244 1.000 45.75659  ? 113 SER B CA  1 
ATOM   879  C C   . SER B 2 53 ? 1.70832   -7.57544  20.26495 1.000 46.02855  ? 113 SER B C   1 
ATOM   880  O O   . SER B 2 53 ? 2.11995   -7.22586  21.37078 1.000 43.50069  ? 113 SER B O   1 
ATOM   881  C CB  . SER B 2 53 ? 3.41077   -8.41845  18.63312 1.000 42.58383  ? 113 SER B CB  1 
ATOM   882  O OG  . SER B 2 53 ? 4.07440   -8.13579  17.40963 1.000 50.10625  ? 113 SER B OG  1 
ATOM   883  N N   . ARG B 2 54 ? 0.56835   -8.23307  20.09675 1.000 47.60789  ? 114 ARG B N   1 
ATOM   884  C CA  . ARG B 2 54 ? -0.27848  -8.60964  21.21187 1.000 47.31632  ? 114 ARG B CA  1 
ATOM   885  C C   . ARG B 2 54 ? -0.28626  -10.12087 21.32253 1.000 45.25662  ? 114 ARG B C   1 
ATOM   886  O O   . ARG B 2 54 ? -0.37357  -10.83058 20.31737 1.000 39.91071  ? 114 ARG B O   1 
ATOM   887  C CB  . ARG B 2 54 ? -1.70089  -8.08207  21.05253 1.000 48.81525  ? 114 ARG B CB  1 
ATOM   888  C CG  . ARG B 2 54 ? -2.67850  -8.56298  22.12090 1.000 48.97593  ? 114 ARG B CG  1 
ATOM   889  C CD  . ARG B 2 54 ? -4.03314  -7.85989  21.98202 1.000 48.14279  ? 114 ARG B CD  1 
ATOM   890  N NE  . ARG B 2 54 ? -4.77476  -8.34287  20.82388 1.000 54.59753  ? 114 ARG B NE  1 
ATOM   891  C CZ  . ARG B 2 54 ? -5.82925  -9.14610  20.89138 1.000 49.40183  ? 114 ARG B CZ  1 
ATOM   892  N NH1 . ARG B 2 54 ? -6.29039  -9.58022  22.04713 1.000 49.98048  ? 114 ARG B NH1 1 
ATOM   893  N NH2 . ARG B 2 54 ? -6.45054  -9.50147  19.76819 1.000 51.44460  ? 114 ARG B NH2 1 
ATOM   894  N N   . PHE B 2 55 ? -0.14065  -10.59494 22.54761 1.000 40.81330  ? 115 PHE B N   1 
ATOM   895  C CA  . PHE B 2 55 ? -0.07561  -12.00741 22.84829 1.000 43.00867  ? 115 PHE B CA  1 
ATOM   896  C C   . PHE B 2 55 ? -1.17293  -12.29256 23.84943 1.000 42.86391  ? 115 PHE B C   1 
ATOM   897  O O   . PHE B 2 55 ? -1.55353  -11.41714 24.62842 1.000 43.37089  ? 115 PHE B O   1 
ATOM   898  C CB  . PHE B 2 55 ? 1.29129   -12.38090 23.43356 1.000 43.34096  ? 115 PHE B CB  1 
ATOM   899  C CG  . PHE B 2 55 ? 2.43066   -12.04073 22.53383 1.000 42.93761  ? 115 PHE B CG  1 
ATOM   900  C CD1 . PHE B 2 55 ? 2.91536   -10.74343 22.47118 1.000 39.28277  ? 115 PHE B CD1 1 
ATOM   901  C CD2 . PHE B 2 55 ? 2.99919   -13.01417 21.72350 1.000 44.53627  ? 115 PHE B CD2 1 
ATOM   902  C CE1 . PHE B 2 55 ? 3.94594   -10.41846 21.61883 1.000 42.78887  ? 115 PHE B CE1 1 
ATOM   903  C CE2 . PHE B 2 55 ? 4.03782   -12.69130 20.85763 1.000 41.85447  ? 115 PHE B CE2 1 
ATOM   904  C CZ  . PHE B 2 55 ? 4.50818   -11.39060 20.80648 1.000 42.19885  ? 115 PHE B CZ  1 
ATOM   905  N N   . ILE B 2 56 ? -1.71340  -13.50169 23.82575 1.000 41.70114  ? 116 ILE B N   1 
ATOM   906  C CA  . ILE B 2 56 ? -2.67923  -13.84862 24.85032 1.000 49.46125  ? 116 ILE B CA  1 
ATOM   907  C C   . ILE B 2 56 ? -2.40772  -15.27146 25.30481 1.000 48.02436  ? 116 ILE B C   1 
ATOM   908  O O   . ILE B 2 56 ? -1.82490  -16.08568 24.58162 1.000 43.98411  ? 116 ILE B O   1 
ATOM   909  C CB  . ILE B 2 56 ? -4.15254  -13.66142 24.38086 1.000 52.14270  ? 116 ILE B CB  1 
ATOM   910  C CG1 . ILE B 2 56 ? -4.55296  -14.75707 23.43814 1.000 51.67644  ? 116 ILE B CG1 1 
ATOM   911  C CG2 . ILE B 2 56 ? -4.40604  -12.28328 23.73366 1.000 47.70301  ? 116 ILE B CG2 1 
ATOM   912  C CD1 . ILE B 2 56 ? -5.30743  -15.81758 24.15636 1.000 53.25189  ? 116 ILE B CD1 1 
ATOM   913  N N   . LYS B 2 57 ? -2.86212  -15.56160 26.51918 1.000 48.13549  ? 117 LYS B N   1 
ATOM   914  C CA  . LYS B 2 57 ? -2.55941  -16.80042 27.21934 1.000 50.67638  ? 117 LYS B CA  1 
ATOM   915  C C   . LYS B 2 57 ? -3.72182  -17.77605 27.09451 1.000 47.60965  ? 117 LYS B C   1 
ATOM   916  O O   . LYS B 2 57 ? -4.87960  -17.39354 27.29284 1.000 45.55655  ? 117 LYS B O   1 
ATOM   917  C CB  . LYS B 2 57 ? -2.28521  -16.49765 28.69658 1.000 48.82376  ? 117 LYS B CB  1 
ATOM   918  C CG  . LYS B 2 57 ? -1.66792  -17.62495 29.49309 1.000 49.84346  ? 117 LYS B CG  1 
ATOM   919  C CD  . LYS B 2 57 ? -1.31636  -17.10247 30.88806 1.000 51.54994  ? 117 LYS B CD  1 
ATOM   920  C CE  . LYS B 2 57 ? -0.34743  -18.01384 31.60329 1.000 56.31676  ? 117 LYS B CE  1 
ATOM   921  N NZ  . LYS B 2 57 ? 0.47853   -17.22581 32.55743 1.000 62.79908  ? 117 LYS B NZ  1 
ATOM   922  N N   . GLU B 2 58 ? -3.41474  -19.02847 26.75884 1.000 47.66359  ? 118 GLU B N   1 
ATOM   923  C CA  . GLU B 2 58 ? -4.38775  -20.11848 26.79167 1.000 49.71314  ? 118 GLU B CA  1 
ATOM   924  C C   . GLU B 2 58 ? -3.73929  -21.30472 27.48345 1.000 53.10919  ? 118 GLU B C   1 
ATOM   925  O O   . GLU B 2 58 ? -2.71165  -21.80667 27.01528 1.000 53.27627  ? 118 GLU B O   1 
ATOM   926  C CB  . GLU B 2 58 ? -4.84668  -20.53660 25.38628 1.000 49.42360  ? 118 GLU B CB  1 
ATOM   927  C CG  . GLU B 2 58 ? -5.37955  -19.41712 24.50520 1.000 53.00786  ? 118 GLU B CG  1 
ATOM   928  C CD  . GLU B 2 58 ? -6.78823  -18.92287 24.88439 1.000 59.00227  ? 118 GLU B CD  1 
ATOM   929  O OE1 . GLU B 2 58 ? -7.41442  -19.45742 25.82947 1.000 56.50365  ? 118 GLU B OE1 1 
ATOM   930  O OE2 . GLU B 2 58 ? -7.27554  -17.98398 24.21570 1.000 60.36943  ? 118 GLU B OE2 1 
ATOM   931  N N   . ASN B 2 59 ? -4.32113  -21.72497 28.60358 1.000 56.45751  ? 119 ASN B N   1 
ATOM   932  C CA  . ASN B 2 59 ? -3.99209  -22.97884 29.27230 1.000 63.42152  ? 119 ASN B CA  1 
ATOM   933  C C   . ASN B 2 59 ? -2.61169  -22.97091 29.91994 1.000 65.35404  ? 119 ASN B C   1 
ATOM   934  O O   . ASN B 2 59 ? -1.78818  -22.08839 29.66955 1.000 60.48244  ? 119 ASN B O   1 
ATOM   935  C CB  . ASN B 2 59 ? -4.11895  -24.14890 28.29574 1.000 63.01436  ? 119 ASN B CB  1 
ATOM   936  C CG  . ASN B 2 59 ? -4.24480  -25.48806 29.00936 1.000 73.11746  ? 119 ASN B CG  1 
ATOM   937  O OD1 . ASN B 2 59 ? -3.79772  -26.52254 28.50574 1.000 69.53019  ? 119 ASN B OD1 1 
ATOM   938  N ND2 . ASN B 2 59 ? -4.83521  -25.46762 30.20402 1.000 72.73649  ? 119 ASN B ND2 1 
ATOM   939  N N   . GLY B 2 60 ? -2.37310  -23.94267 30.79255 1.000 82.55579  ? 120 GLY B N   1 
ATOM   940  C CA  . GLY B 2 60 ? -1.19409  -23.95172 31.64480 1.000 85.16808  ? 120 GLY B CA  1 
ATOM   941  C C   . GLY B 2 60 ? -1.50128  -23.71858 33.12018 1.000 85.70020  ? 120 GLY B C   1 
ATOM   942  O O   . GLY B 2 60 ? -2.60505  -23.28810 33.49739 1.000 82.34079  ? 120 GLY B O   1 
ATOM   943  O OXT . GLY B 2 60 ? -0.63814  -23.95232 33.97386 1.000 87.14438  ? 120 GLY B OXT 1 
ATOM   944  N N   . GLN C 3 1  ? 0.38088   -20.94344 28.69719 1.000 56.07268  ? 121 GLN C N   1 
ATOM   945  C CA  . GLN C 3 1  ? 1.07525   -20.81249 27.41058 1.000 54.41694  ? 121 GLN C CA  1 
ATOM   946  C C   . GLN C 3 1  ? 0.61575   -19.59565 26.59312 1.000 51.02235  ? 121 GLN C C   1 
ATOM   947  O O   . GLN C 3 1  ? -0.57558  -19.38182 26.36799 1.000 49.62193  ? 121 GLN C O   1 
ATOM   948  C CB  . GLN C 3 1  ? 0.90894   -22.09277 26.58307 1.000 51.39182  ? 121 GLN C CB  1 
ATOM   949  C CG  . GLN C 3 1  ? 1.90714   -22.16901 25.45096 1.000 60.03768  ? 121 GLN C CG  1 
ATOM   950  C CD  . GLN C 3 1  ? 1.94480   -23.52413 24.73918 1.000 67.86821  ? 121 GLN C CD  1 
ATOM   951  O OE1 . GLN C 3 1  ? 1.86251   -24.58193 25.37717 1.000 65.47218  ? 121 GLN C OE1 1 
ATOM   952  N NE2 . GLN C 3 1  ? 2.09271   -23.49120 23.40164 1.000 58.76337  ? 121 GLN C NE2 1 
ATOM   953  N N   . TRP C 3 2  ? 1.57793   -18.80050 26.13820 1.000 49.61828  ? 122 TRP C N   1 
ATOM   954  C CA  . TRP C 3 2  ? 1.29217   -17.58984 25.38692 1.000 46.84549  ? 122 TRP C CA  1 
ATOM   955  C C   . TRP C 3 2  ? 1.28333   -17.85386 23.88369 1.000 46.93284  ? 122 TRP C C   1 
ATOM   956  O O   . TRP C 3 2  ? 2.03643   -18.68777 23.37459 1.000 46.95487  ? 122 TRP C O   1 
ATOM   957  C CB  . TRP C 3 2  ? 2.32509   -16.51116 25.71037 1.000 45.03930  ? 122 TRP C CB  1 
ATOM   958  C CG  . TRP C 3 2  ? 2.25080   -16.01981 27.09908 1.000 44.64155  ? 122 TRP C CG  1 
ATOM   959  C CD1 . TRP C 3 2  ? 3.00371   -16.44515 28.16356 1.000 45.12647  ? 122 TRP C CD1 1 
ATOM   960  C CD2 . TRP C 3 2  ? 1.38325   -14.99122 27.60163 1.000 44.89593  ? 122 TRP C CD2 1 
ATOM   961  N NE1 . TRP C 3 2  ? 2.65636   -15.73923 29.29674 1.000 44.33097  ? 122 TRP C NE1 1 
ATOM   962  C CE2 . TRP C 3 2  ? 1.65780   -14.85194 28.98378 1.000 46.27611  ? 122 TRP C CE2 1 
ATOM   963  C CE3 . TRP C 3 2  ? 0.40041   -14.17939 27.02136 1.000 42.12476  ? 122 TRP C CE3 1 
ATOM   964  C CZ2 . TRP C 3 2  ? 0.98876   -13.92913 29.78821 1.000 41.16115  ? 122 TRP C CZ2 1 
ATOM   965  C CZ3 . TRP C 3 2  ? -0.24682  -13.25987 27.80856 1.000 42.92848  ? 122 TRP C CZ3 1 
ATOM   966  C CH2 . TRP C 3 2  ? 0.04312   -13.14232 29.18357 1.000 47.46048  ? 122 TRP C CH2 1 
ATOM   967  N N   . TYR C 3 3  ? 0.42317   -17.12293 23.17209 1.000 43.30580  ? 123 TYR C N   1 
ATOM   968  C CA  . TYR C 3 3  ? 0.28874   -17.24851 21.72442 1.000 48.03105  ? 123 TYR C CA  1 
ATOM   969  C C   . TYR C 3 3  ? 0.27143   -15.86909 21.09681 1.000 45.11498  ? 123 TYR C C   1 
ATOM   970  O O   . TYR C 3 3  ? -0.34010  -14.94659 21.63878 1.000 42.96188  ? 123 TYR C O   1 
ATOM   971  C CB  . TYR C 3 3  ? -1.00592  -18.00102 21.32244 1.000 45.58933  ? 123 TYR C CB  1 
ATOM   972  C CG  . TYR C 3 3  ? -1.01775  -19.43721 21.77438 1.000 43.83355  ? 123 TYR C CG  1 
ATOM   973  C CD1 . TYR C 3 3  ? -1.45276  -19.78107 23.05133 1.000 45.97775  ? 123 TYR C CD1 1 
ATOM   974  C CD2 . TYR C 3 3  ? -0.55638  -20.44845 20.93656 1.000 47.10158  ? 123 TYR C CD2 1 
ATOM   975  C CE1 . TYR C 3 3  ? -1.44577  -21.10942 23.48256 1.000 46.52243  ? 123 TYR C CE1 1 
ATOM   976  C CE2 . TYR C 3 3  ? -0.54387  -21.77405 21.34824 1.000 46.64250  ? 123 TYR C CE2 1 
ATOM   977  C CZ  . TYR C 3 3  ? -0.99138  -22.09811 22.61595 1.000 51.45517  ? 123 TYR C CZ  1 
ATOM   978  O OH  . TYR C 3 3  ? -0.96337  -23.41349 23.00827 1.000 53.35113  ? 123 TYR C OH  1 
ATOM   979  N N   . TYR C 3 4  ? 0.94407   -15.73081 19.95494 1.000 46.41411  ? 124 TYR C N   1 
ATOM   980  C CA  . TYR C 3 4  ? 0.82221   -14.51687 19.16302 1.000 46.10445  ? 124 TYR C CA  1 
ATOM   981  C C   . TYR C 3 4  ? -0.55976  -14.45148 18.51526 1.000 42.16879  ? 124 TYR C C   1 
ATOM   982  O O   . TYR C 3 4  ? -1.11151  -15.47525 18.10806 1.000 45.38679  ? 124 TYR C O   1 
ATOM   983  C CB  . TYR C 3 4  ? 1.90145   -14.48182 18.08459 1.000 46.06080  ? 124 TYR C CB  1 
ATOM   984  C CG  . TYR C 3 4  ? 1.69886   -13.35084 17.09967 1.000 47.05848  ? 124 TYR C CG  1 
ATOM   985  C CD1 . TYR C 3 4  ? 2.16884   -12.07350 17.38166 1.000 47.34922  ? 124 TYR C CD1 1 
ATOM   986  C CD2 . TYR C 3 4  ? 1.00899   -13.54662 15.90720 1.000 48.12816  ? 124 TYR C CD2 1 
ATOM   987  C CE1 . TYR C 3 4  ? 1.98166   -11.02620 16.49741 1.000 49.25523  ? 124 TYR C CE1 1 
ATOM   988  C CE2 . TYR C 3 4  ? 0.79947   -12.49809 15.02232 1.000 46.52819  ? 124 TYR C CE2 1 
ATOM   989  C CZ  . TYR C 3 4  ? 1.28994   -11.24090 15.32333 1.000 50.40156  ? 124 TYR C CZ  1 
ATOM   990  O OH  . TYR C 3 4  ? 1.11841   -10.18948 14.44334 1.000 54.07189  ? 124 TYR C OH  1 
ATOM   991  N N   . ILE C 3 5  ? -1.12198  -13.23891 18.41548 1.000 44.90990  ? 125 ILE C N   1 
ATOM   992  C CA  . ILE C 3 5  ? -2.45537  -13.08441 17.81960 1.000 47.31271  ? 125 ILE C CA  1 
ATOM   993  C C   . ILE C 3 5  ? -2.46413  -11.97792 16.76149 1.000 49.78068  ? 125 ILE C C   1 
ATOM   994  O O   . ILE C 3 5  ? -2.80215  -12.23693 15.60302 1.000 52.28083  ? 125 ILE C O   1 
ATOM   995  C CB  . ILE C 3 5  ? -3.55083  -12.86832 18.90076 1.000 48.56872  ? 125 ILE C CB  1 
ATOM   996  C CG1 . ILE C 3 5  ? -4.93781  -12.62419 18.28027 1.000 51.72055  ? 125 ILE C CG1 1 
ATOM   997  C CG2 . ILE C 3 5  ? -3.27889  -11.66637 19.77422 1.000 45.41514  ? 125 ILE C CG2 1 
ATOM   998  C CD1 . ILE C 3 5  ? -5.60980  -13.81628 17.65552 1.000 45.55867  ? 125 ILE C CD1 1 
ATOM   999  N N   . ASP C 3 6  ? -2.08949  -10.75018 17.11798 1.000 51.72344  ? 126 ASP C N   1 
ATOM   1000 C CA  . ASP C 3 6  ? -2.10832  -9.65364  16.14078 1.000 50.21883  ? 126 ASP C CA  1 
ATOM   1001 C C   . ASP C 3 6  ? -1.18840  -8.54012  16.63717 1.000 52.38452  ? 126 ASP C C   1 
ATOM   1002 O O   . ASP C 3 6  ? -0.42740  -8.72680  17.59413 1.000 51.56164  ? 126 ASP C O   1 
ATOM   1003 C CB  . ASP C 3 6  ? -3.54563  -9.17810  15.89466 1.000 50.94592  ? 126 ASP C CB  1 
ATOM   1004 C CG  . ASP C 3 6  ? -4.19644  -8.58360  17.12805 1.000 54.55787  ? 126 ASP C CG  1 
ATOM   1005 O OD1 . ASP C 3 6  ? -3.48135  -8.04474  18.00896 1.000 57.86843  ? 126 ASP C OD1 1 
ATOM   1006 O OD2 . ASP C 3 6  ? -5.44160  -8.63735  17.22275 1.000 57.74306  ? 126 ASP C OD2 1 
ATOM   1007 N N   . GLY C 3 7  ? -1.27256  -7.36879  16.01120 1.000 47.75970  ? 127 GLY C N   1 
ATOM   1008 C CA  . GLY C 3 7  ? -0.42823  -6.26572  16.43424 1.000 48.42028  ? 127 GLY C CA  1 
ATOM   1009 C C   . GLY C 3 7  ? -0.87160  -4.95767  15.81846 1.000 53.67462  ? 127 GLY C C   1 
ATOM   1010 O O   . GLY C 3 7  ? -1.71322  -4.92582  14.92302 1.000 58.07962  ? 127 GLY C O   1 
ATOM   1011 N N   . THR C 3 8  ? -0.30331  -3.86220  16.32849 1.000 54.49908  ? 128 THR C N   1 
ATOM   1012 C CA  . THR C 3 8  ? -0.50857  -2.53974  15.75038 1.000 59.33695  ? 128 THR C CA  1 
ATOM   1013 C C   . THR C 3 8  ? 0.83464   -1.82680  15.66637 1.000 62.04132  ? 128 THR C C   1 
ATOM   1014 O O   . THR C 3 8  ? 1.83019   -2.26803  16.23567 1.000 60.03889  ? 128 THR C O   1 
ATOM   1015 C CB  . THR C 3 8  ? -1.50839  -1.68435  16.55100 1.000 56.79042  ? 128 THR C CB  1 
ATOM   1016 O OG1 . THR C 3 8  ? -1.08667  -1.58390  17.92090 1.000 62.50710  ? 128 THR C OG1 1 
ATOM   1017 C CG2 . THR C 3 8  ? -2.89469  -2.27917  16.48736 1.000 61.90682  ? 128 THR C CG2 1 
ATOM   1018 N N   . ARG C 3 9  ? 0.85624   -0.71164  14.93672 1.000 67.78275  ? 129 ARG C N   1 
ATOM   1019 C CA  . ARG C 3 9  ? 2.05704   0.09298   14.77168 1.000 70.78021  ? 129 ARG C CA  1 
ATOM   1020 C C   . ARG C 3 9  ? 1.96977   1.28389   15.72010 1.000 76.19201  ? 129 ARG C C   1 
ATOM   1021 O O   . ARG C 3 9  ? 1.27492   2.26087   15.40797 1.000 78.19229  ? 129 ARG C O   1 
ATOM   1022 C CB  . ARG C 3 9  ? 2.19500   0.56755   13.31849 1.000 74.43279  ? 129 ARG C CB  1 
ATOM   1023 C CG  . ARG C 3 9  ? 2.39000   -0.54037  12.27912 1.000 74.22636  ? 129 ARG C CG  1 
ATOM   1024 C CD  . ARG C 3 9  ? 1.07819   -1.27578  11.90737 1.000 77.57762  ? 129 ARG C CD  1 
ATOM   1025 N NE  . ARG C 3 9  ? -0.09220  -0.41457  12.05269 1.000 83.92042  ? 129 ARG C NE  1 
ATOM   1026 C CZ  . ARG C 3 9  ? -0.49895  0.44920   11.13357 1.000 87.39756  ? 129 ARG C CZ  1 
ATOM   1027 N NH1 . ARG C 3 9  ? 0.12064   0.55290   9.96755  1.000 85.49591  ? 129 ARG C NH1 1 
ATOM   1028 N NH2 . ARG C 3 9  ? -1.54691  1.23153   11.39483 1.000 85.20440  ? 129 ARG C NH2 1 
ATOM   1029 N N   . PRO C 3 10 ? 2.68729   1.28197   16.84927 1.000 78.16513  ? 130 PRO C N   1 
ATOM   1030 C CA  . PRO C 3 10 ? 2.43337   2.29877   17.88329 1.000 80.70027  ? 130 PRO C CA  1 
ATOM   1031 C C   . PRO C 3 10 ? 2.75695   3.69782   17.38088 1.000 93.96375  ? 130 PRO C C   1 
ATOM   1032 O O   . PRO C 3 10 ? 3.68807   3.89485   16.59445 1.000 95.79134  ? 130 PRO C O   1 
ATOM   1033 C CB  . PRO C 3 10 ? 3.37074   1.88234   19.01981 1.000 79.47885  ? 130 PRO C CB  1 
ATOM   1034 C CG  . PRO C 3 10 ? 4.54223   1.26852   18.29674 1.000 76.53343  ? 130 PRO C CG  1 
ATOM   1035 C CD  . PRO C 3 10 ? 3.96024   0.57121   17.07423 1.000 70.12301  ? 130 PRO C CD  1 
ATOM   1036 N N   . GLN C 3 11 ? 1.96813   4.67655   17.83519 1.000 100.03039 ? 131 GLN C N   1 
ATOM   1037 C CA  . GLN C 3 11 ? 2.17294   6.06108   17.41578 1.000 105.65267 ? 131 GLN C CA  1 
ATOM   1038 C C   . GLN C 3 11 ? 3.44097   6.61534   18.05663 1.000 111.11380 ? 131 GLN C C   1 
ATOM   1039 O O   . GLN C 3 11 ? 3.56979   6.63350   19.28750 1.000 108.53720 ? 131 GLN C O   1 
ATOM   1040 C CB  . GLN C 3 11 ? 0.97004   6.93151   17.78091 1.000 103.70105 ? 131 GLN C CB  1 
ATOM   1041 C CG  . GLN C 3 11 ? -0.22985  6.78050   16.86606 1.000 102.24515 ? 131 GLN C CG  1 
ATOM   1042 C CD  . GLN C 3 11 ? -1.18152  5.70959   17.34883 1.000 103.59462 ? 131 GLN C CD  1 
ATOM   1043 O OE1 . GLN C 3 11 ? -0.96568  5.09894   18.39894 1.000 102.34752 ? 131 GLN C OE1 1 
ATOM   1044 N NE2 . GLN C 3 11 ? -2.24383  5.47372   16.58700 1.000 106.93048 ? 131 GLN C NE2 1 
ATOM   1045 N N   . LEU C 3 12 ? 4.37552   7.06420   17.21723 1.000 117.24657 ? 132 LEU C N   1 
ATOM   1046 C CA  . LEU C 3 12 ? 5.62531   7.67243   17.66793 1.000 121.36856 ? 132 LEU C CA  1 
ATOM   1047 C C   . LEU C 3 12 ? 6.00216   8.77339   16.68465 1.000 129.14512 ? 132 LEU C C   1 
ATOM   1048 O O   . LEU C 3 12 ? 6.16216   8.50873   15.48649 1.000 131.05333 ? 132 LEU C O   1 
ATOM   1049 C CB  . LEU C 3 12 ? 6.74995   6.63044   17.77965 1.000 118.61881 ? 132 LEU C CB  1 
ATOM   1050 C CG  . LEU C 3 12 ? 6.59205   5.50749   18.81586 1.000 110.08673 ? 132 LEU C CG  1 
ATOM   1051 C CD1 . LEU C 3 12 ? 7.71241   4.47672   18.69635 1.000 100.06060 ? 132 LEU C CD1 1 
ATOM   1052 C CD2 . LEU C 3 12 ? 6.53047   6.07120   20.22910 1.000 112.37884 ? 132 LEU C CD2 1 
ATOM   1053 N N   . GLY C 3 13 ? 6.13631   10.00391  17.19101 1.000 130.28065 ? 133 GLY C N   1 
ATOM   1054 C CA  . GLY C 3 13 ? 6.41379   11.13824  16.33055 1.000 134.34077 ? 133 GLY C CA  1 
ATOM   1055 C C   . GLY C 3 13 ? 7.79864   11.08521  15.71288 1.000 136.33271 ? 133 GLY C C   1 
ATOM   1056 O O   . GLY C 3 13 ? 8.69243   10.36821  16.16388 1.000 136.09956 ? 133 GLY C O   1 
ATOM   1057 N N   . ARG C 3 14 ? 7.98126   11.88665  14.65997 1.000 135.31559 ? 134 ARG C N   1 
ATOM   1058 C CA  . ARG C 3 14 ? 9.19736   11.79474  13.85957 1.000 135.36288 ? 134 ARG C CA  1 
ATOM   1059 C C   . ARG C 3 14 ? 10.40929  12.44222  14.52657 1.000 136.93189 ? 134 ARG C C   1 
ATOM   1060 O O   . ARG C 3 14 ? 11.54440  12.08433  14.19613 1.000 134.08904 ? 134 ARG C O   1 
ATOM   1061 C CB  . ARG C 3 14 ? 8.95874   12.41968  12.48931 1.000 136.19768 ? 134 ARG C CB  1 
ATOM   1062 C CG  . ARG C 3 14 ? 7.88669   11.73248  11.66892 1.000 134.66270 ? 134 ARG C CG  1 
ATOM   1063 C CD  . ARG C 3 14 ? 7.75037   12.44023  10.34638 1.000 134.77745 ? 134 ARG C CD  1 
ATOM   1064 N NE  . ARG C 3 14 ? 9.03268   12.50450  9.65702  1.000 135.59683 ? 134 ARG C NE  1 
ATOM   1065 C CZ  . ARG C 3 14 ? 9.46371   13.55459  8.97185  1.000 136.32287 ? 134 ARG C CZ  1 
ATOM   1066 N NH1 . ARG C 3 14 ? 8.76018   14.67353  8.90498  1.000 132.88130 ? 134 ARG C NH1 1 
ATOM   1067 N NH2 . ARG C 3 14 ? 10.63439  13.48322  8.34486  1.000 136.76814 ? 134 ARG C NH2 1 
ATOM   1068 N N   . ASN C 3 15 ? 10.20682  13.37748  15.45472 1.000 138.50527 ? 135 ASN C N   1 
ATOM   1069 C CA  . ASN C 3 15 ? 11.31870  14.05006  16.11870 1.000 138.98277 ? 135 ASN C CA  1 
ATOM   1070 C C   . ASN C 3 15 ? 11.68953  13.42108  17.45903 1.000 135.61041 ? 135 ASN C C   1 
ATOM   1071 O O   . ASN C 3 15 ? 12.73648  13.76672  18.01900 1.000 135.34937 ? 135 ASN C O   1 
ATOM   1072 C CB  . ASN C 3 15 ? 10.98958  15.53782  16.33019 1.000 140.59073 ? 135 ASN C CB  1 
ATOM   1073 C CG  . ASN C 3 15 ? 12.16690  16.45611  16.01630 1.000 140.66007 ? 135 ASN C CG  1 
ATOM   1074 O OD1 . ASN C 3 15 ? 12.85474  16.28662  15.00584 1.000 139.37108 ? 135 ASN C OD1 1 
ATOM   1075 N ND2 . ASN C 3 15 ? 12.40183  17.43473  16.88754 1.000 138.02849 ? 135 ASN C ND2 1 
ATOM   1076 N N   . ASP C 3 16 ? 10.87173  12.50593  17.97667 1.000 134.02710 ? 136 ASP C N   1 
ATOM   1077 C CA  . ASP C 3 16 ? 11.08667  11.94973  19.30254 1.000 131.76165 ? 136 ASP C CA  1 
ATOM   1078 C C   . ASP C 3 16 ? 12.37541  11.12880  19.34553 1.000 129.32922 ? 136 ASP C C   1 
ATOM   1079 O O   . ASP C 3 16 ? 12.90621  10.73366  18.30204 1.000 129.03403 ? 136 ASP C O   1 
ATOM   1080 C CB  . ASP C 3 16 ? 9.89017   11.08752  19.70158 1.000 130.88209 ? 136 ASP C CB  1 
ATOM   1081 C CG  . ASP C 3 16 ? 8.61644   11.89606  19.85384 1.000 131.59146 ? 136 ASP C CG  1 
ATOM   1082 O OD1 . ASP C 3 16 ? 8.68268   12.99870  20.43636 1.000 131.82269 ? 136 ASP C OD1 1 
ATOM   1083 O OD2 . ASP C 3 16 ? 7.55328   11.43528  19.38494 1.000 128.86165 ? 136 ASP C OD2 1 
ATOM   1084 N N   . PRO C 3 17 ? 12.90976  10.87504  20.54334 1.000 127.72511 ? 137 PRO C N   1 
ATOM   1085 C CA  . PRO C 3 17 ? 14.08133  9.98916   20.65300 1.000 126.05290 ? 137 PRO C CA  1 
ATOM   1086 C C   . PRO C 3 17 ? 13.75470  8.59556   20.13366 1.000 122.47893 ? 137 PRO C C   1 
ATOM   1087 O O   . PRO C 3 17 ? 12.82994  7.93814   20.61704 1.000 123.01495 ? 137 PRO C O   1 
ATOM   1088 C CB  . PRO C 3 17 ? 14.38492  9.98625   22.15883 1.000 121.24052 ? 137 PRO C CB  1 
ATOM   1089 C CG  . PRO C 3 17 ? 13.11511  10.44005  22.82095 1.000 117.64317 ? 137 PRO C CG  1 
ATOM   1090 C CD  . PRO C 3 17 ? 12.50378  11.41200  21.85762 1.000 124.93944 ? 137 PRO C CD  1 
ATOM   1091 N N   . CYS C 3 18 ? 14.51627  8.15350   19.13316 1.000 120.81449 ? 138 CYS C N   1 
ATOM   1092 C CA  . CYS C 3 18 ? 14.24900  6.86691   18.50154 1.000 116.83391 ? 138 CYS C CA  1 
ATOM   1093 C C   . CYS C 3 18 ? 14.28083  5.75272   19.54872 1.000 110.74480 ? 138 CYS C C   1 
ATOM   1094 O O   . CYS C 3 18 ? 15.14088  5.76230   20.43957 1.000 110.30987 ? 138 CYS C O   1 
ATOM   1095 C CB  . CYS C 3 18 ? 15.26750  6.59230   17.38370 1.000 117.98191 ? 138 CYS C CB  1 
ATOM   1096 S SG  . CYS C 3 18 ? 15.20877  4.91173   16.65759 1.000 120.46287 ? 138 CYS C SG  1 
ATOM   1097 N N   . PRO C 3 19 ? 13.33709  4.80386   19.49870 1.000 107.28099 ? 139 PRO C N   1 
ATOM   1098 C CA  . PRO C 3 19 ? 13.37815  3.67136   20.44547 1.000 99.56313  ? 139 PRO C CA  1 
ATOM   1099 C C   . PRO C 3 19 ? 14.60794  2.79125   20.28048 1.000 101.50981 ? 139 PRO C C   1 
ATOM   1100 O O   . PRO C 3 19 ? 14.94030  2.03010   21.19913 1.000 97.33594  ? 139 PRO C O   1 
ATOM   1101 C CB  . PRO C 3 19 ? 12.08831  2.89865   20.12940 1.000 86.23775  ? 139 PRO C CB  1 
ATOM   1102 C CG  . PRO C 3 19 ? 11.20024  3.88818   19.43345 1.000 91.49185  ? 139 PRO C CG  1 
ATOM   1103 C CD  . PRO C 3 19 ? 12.12621  4.78425   18.65973 1.000 104.44722 ? 139 PRO C CD  1 
ATOM   1104 N N   . CYS C 3 20 ? 15.28700  2.87455   19.13228 1.000 106.51578 ? 140 CYS C N   1 
ATOM   1105 C CA  . CYS C 3 20 ? 16.57449  2.22832   18.89932 1.000 108.32695 ? 140 CYS C CA  1 
ATOM   1106 C C   . CYS C 3 20 ? 17.64782  2.67113   19.88455 1.000 111.96334 ? 140 CYS C C   1 
ATOM   1107 O O   . CYS C 3 20 ? 18.71655  2.05142   19.92372 1.000 111.85589 ? 140 CYS C O   1 
ATOM   1108 C CB  . CYS C 3 20 ? 17.04246  2.53810   17.47398 1.000 111.21565 ? 140 CYS C CB  1 
ATOM   1109 S SG  . CYS C 3 20 ? 17.10369  4.32940   17.16402 1.000 123.13142 ? 140 CYS C SG  1 
ATOM   1110 N N   . GLY C 3 21 ? 17.40132  3.72860   20.66088 1.000 113.04815 ? 141 GLY C N   1 
ATOM   1111 C CA  . GLY C 3 21 ? 18.40203  4.28256   21.54991 1.000 114.99372 ? 141 GLY C CA  1 
ATOM   1112 C C   . GLY C 3 21 ? 19.53001  5.02155   20.86434 1.000 119.02651 ? 141 GLY C C   1 
ATOM   1113 O O   . GLY C 3 21 ? 20.45850  5.46861   21.54568 1.000 119.42095 ? 141 GLY C O   1 
ATOM   1114 N N   . SER C 3 22 ? 19.47467  5.17745   19.53498 1.000 117.91539 ? 142 SER C N   1 
ATOM   1115 C CA  . SER C 3 22 ? 20.53980  5.81772   18.76534 1.000 121.02789 ? 142 SER C CA  1 
ATOM   1116 C C   . SER C 3 22 ? 20.73407  7.28843   19.12738 1.000 124.68178 ? 142 SER C C   1 
ATOM   1117 O O   . SER C 3 22 ? 21.67590  7.91123   18.61411 1.000 123.40059 ? 142 SER C O   1 
ATOM   1118 C CB  . SER C 3 22 ? 20.26518  5.70260   17.25774 1.000 119.26812 ? 142 SER C CB  1 
ATOM   1119 O OG  . SER C 3 22 ? 20.23310  4.34265   16.82193 1.000 116.32014 ? 142 SER C OG  1 
ATOM   1120 N N   . GLY C 3 23 ? 19.88545  7.85602   19.99203 1.000 126.09065 ? 143 GLY C N   1 
ATOM   1121 C CA  . GLY C 3 23 ? 19.98321  9.25933   20.35100 1.000 125.07617 ? 143 GLY C CA  1 
ATOM   1122 C C   . GLY C 3 23 ? 19.31337  10.16674  19.33961 1.000 126.32259 ? 143 GLY C C   1 
ATOM   1123 O O   . GLY C 3 23 ? 18.62977  11.12453  19.71385 1.000 126.01718 ? 143 GLY C O   1 
ATOM   1124 N N   . LYS C 3 24 ? 19.49233  9.85375   18.05172 1.000 127.91065 ? 144 LYS C N   1 
ATOM   1125 C CA  . LYS C 3 24 ? 18.91689  10.60401  16.93783 1.000 128.98872 ? 144 LYS C CA  1 
ATOM   1126 C C   . LYS C 3 24 ? 17.39190  10.59099  16.98013 1.000 130.62171 ? 144 LYS C C   1 
ATOM   1127 O O   . LYS C 3 24 ? 16.79339  9.92277   17.82979 1.000 131.39638 ? 144 LYS C O   1 
ATOM   1128 C CB  . LYS C 3 24 ? 19.41325  10.02482  15.60735 1.000 127.18247 ? 144 LYS C CB  1 
ATOM   1129 C CG  . LYS C 3 24 ? 20.90404  9.71236   15.60137 1.000 124.56880 ? 144 LYS C CG  1 
ATOM   1130 C CD  . LYS C 3 24 ? 21.19750  8.36945   14.95071 1.000 121.96286 ? 144 LYS C CD  1 
ATOM   1131 C CE  . LYS C 3 24 ? 21.01149  8.42364   13.44718 1.000 122.95880 ? 144 LYS C CE  1 
ATOM   1132 N NZ  . LYS C 3 24 ? 21.33195  7.11992   12.80050 1.000 120.43695 ? 144 LYS C NZ  1 
ATOM   1133 N N   . LYS C 3 25 ? 16.75157  11.31879  16.06881 1.000 131.83793 ? 145 LYS C N   1 
ATOM   1134 C CA  . LYS C 3 25 ? 15.29912  11.36566  16.05312 1.000 132.91896 ? 145 LYS C CA  1 
ATOM   1135 C C   . LYS C 3 25 ? 14.72908  10.11509  15.38410 1.000 132.52348 ? 145 LYS C C   1 
ATOM   1136 O O   . LYS C 3 25 ? 15.44627  9.31034   14.77894 1.000 128.79133 ? 145 LYS C O   1 
ATOM   1137 C CB  . LYS C 3 25 ? 14.80973  12.63742  15.35407 1.000 136.19164 ? 145 LYS C CB  1 
ATOM   1138 C CG  . LYS C 3 25 ? 15.54848  12.98134  14.06774 1.000 136.92882 ? 145 LYS C CG  1 
ATOM   1139 C CD  . LYS C 3 25 ? 15.30836  14.42034  13.63239 1.000 140.57253 ? 145 LYS C CD  1 
ATOM   1140 C CE  . LYS C 3 25 ? 16.12000  14.76930  12.39001 1.000 141.65246 ? 145 LYS C CE  1 
ATOM   1141 N NZ  . LYS C 3 25 ? 15.98633  16.20589  12.01045 1.000 145.29792 ? 145 LYS C NZ  1 
ATOM   1142 N N   . PHE C 3 26 ? 13.41093  9.95025   15.52119 1.000 132.28688 ? 146 PHE C N   1 
ATOM   1143 C CA  . PHE C 3 26 ? 12.73868  8.80644   14.91314 1.000 132.97561 ? 146 PHE C CA  1 
ATOM   1144 C C   . PHE C 3 26 ? 12.84345  8.84926   13.39353 1.000 133.75834 ? 146 PHE C C   1 
ATOM   1145 O O   . PHE C 3 26 ? 13.08050  7.81829   12.75224 1.000 130.95175 ? 146 PHE C O   1 
ATOM   1146 C CB  . PHE C 3 26 ? 11.27667  8.76781   15.36113 1.000 133.18947 ? 146 PHE C CB  1 
ATOM   1147 C CG  . PHE C 3 26 ? 10.40977  7.83842   14.55288 1.000 133.42748 ? 146 PHE C CG  1 
ATOM   1148 C CD1 . PHE C 3 26 ? 10.58847  6.46914   14.62052 1.000 129.05587 ? 146 PHE C CD1 1 
ATOM   1149 C CD2 . PHE C 3 26 ? 9.39997   8.33790   13.73916 1.000 133.49324 ? 146 PHE C CD2 1 
ATOM   1150 C CE1 . PHE C 3 26 ? 9.78421   5.61947   13.88468 1.000 125.23430 ? 146 PHE C CE1 1 
ATOM   1151 C CE2 . PHE C 3 26 ? 8.59321   7.49128   13.00192 1.000 129.48464 ? 146 PHE C CE2 1 
ATOM   1152 C CZ  . PHE C 3 26 ? 8.78604   6.13117   13.07354 1.000 125.87928 ? 146 PHE C CZ  1 
ATOM   1153 N N   . LYS C 3 27 ? 12.68308  10.03779  12.80249 1.000 136.30548 ? 147 LYS C N   1 
ATOM   1154 C CA  . LYS C 3 27 ? 12.82083  10.25601  11.36614 1.000 134.74222 ? 147 LYS C CA  1 
ATOM   1155 C C   . LYS C 3 27 ? 14.27720  10.28875  10.91011 1.000 134.11591 ? 147 LYS C C   1 
ATOM   1156 O O   . LYS C 3 27 ? 14.54799  10.70736  9.77851  1.000 132.95798 ? 147 LYS C O   1 
ATOM   1157 C CB  . LYS C 3 27 ? 12.11519  11.55691  10.96034 1.000 135.87312 ? 147 LYS C CB  1 
ATOM   1158 C CG  . LYS C 3 27 ? 12.80706  12.84287  11.42261 1.000 138.93858 ? 147 LYS C CG  1 
ATOM   1159 C CD  . LYS C 3 27 ? 11.85516  14.03322  11.34956 1.000 140.91256 ? 147 LYS C CD  1 
ATOM   1160 C CE  . LYS C 3 27 ? 12.54065  15.35585  11.65261 1.000 147.48848 ? 147 LYS C CE  1 
ATOM   1161 N NZ  . LYS C 3 27 ? 13.44754  15.78574  10.55502 1.000 167.64848 ? 147 LYS C NZ  1 
ATOM   1162 N N   . LYS C 3 28 ? 15.20930  9.85784   11.76113 1.000 134.00477 ? 148 LYS C N   1 
ATOM   1163 C CA  . LYS C 3 28 ? 16.63516  9.77058   11.45745 1.000 133.25934 ? 148 LYS C CA  1 
ATOM   1164 C C   . LYS C 3 28 ? 17.20387  8.38179   11.70968 1.000 131.57310 ? 148 LYS C C   1 
ATOM   1165 O O   . LYS C 3 28 ? 17.97717  7.87979   10.88650 1.000 129.35471 ? 148 LYS C O   1 
ATOM   1166 C CB  . LYS C 3 28 ? 17.42003  10.80824  12.28580 1.000 131.01545 ? 148 LYS C CB  1 
ATOM   1167 C CG  . LYS C 3 28 ? 18.87456  10.99997  11.87273 1.000 128.98630 ? 148 LYS C CG  1 
ATOM   1168 C CD  . LYS C 3 28 ? 18.98257  11.51465  10.44152 1.000 127.13673 ? 148 LYS C CD  1 
ATOM   1169 C CE  . LYS C 3 28 ? 20.43186  11.59579  9.98286  1.000 120.73475 ? 148 LYS C CE  1 
ATOM   1170 N NZ  . LYS C 3 28 ? 20.53537  11.58913  8.49863  1.000 109.71499 ? 148 LYS C NZ  1 
ATOM   1171 N N   . CYS C 3 29 ? 16.82844  7.74142   12.81721 1.000 128.93523 ? 149 CYS C N   1 
ATOM   1172 C CA  . CYS C 3 29 ? 17.41611  6.46636   13.20677 1.000 125.69821 ? 149 CYS C CA  1 
ATOM   1173 C C   . CYS C 3 29 ? 16.87723  5.32046   12.34604 1.000 125.24526 ? 149 CYS C C   1 
ATOM   1174 O O   . CYS C 3 29 ? 17.57682  4.83701   11.44780 1.000 120.94863 ? 149 CYS C O   1 
ATOM   1175 C CB  . CYS C 3 29 ? 17.17948  6.24306   14.71005 1.000 123.62810 ? 149 CYS C CB  1 
ATOM   1176 S SG  . CYS C 3 29 ? 16.63117  4.60201   15.22809 1.000 122.43407 ? 149 CYS C SG  1 
ATOM   1177 N N   . CYS C 3 30 ? 15.62746  4.90391   12.57991 1.000 125.74175 ? 150 CYS C N   1 
ATOM   1178 C CA  . CYS C 3 30 ? 15.06668  3.71283   11.95632 1.000 121.15842 ? 150 CYS C CA  1 
ATOM   1179 C C   . CYS C 3 30 ? 13.64904  3.93590   11.43492 1.000 118.15744 ? 150 CYS C C   1 
ATOM   1180 O O   . CYS C 3 30 ? 13.07032  3.01440   10.84786 1.000 108.44600 ? 150 CYS C O   1 
ATOM   1181 C CB  . CYS C 3 30 ? 15.07058  2.51925   12.94467 1.000 117.01136 ? 150 CYS C CB  1 
ATOM   1182 S SG  . CYS C 3 30 ? 16.70352  1.79990   13.49050 1.000 104.53417 ? 150 CYS C SG  1 
ATOM   1183 N N   . GLY C 3 31 ? 13.07369  5.12167   11.63416 1.000 122.80418 ? 151 GLY C N   1 
ATOM   1184 C CA  . GLY C 3 31 ? 11.75870  5.43681   11.10616 1.000 126.21687 ? 151 GLY C CA  1 
ATOM   1185 C C   . GLY C 3 31 ? 11.78899  6.54689   10.07280 1.000 133.54479 ? 151 GLY C C   1 
ATOM   1186 O O   . GLY C 3 31 ? 11.13816  7.58573   10.24132 1.000 134.80166 ? 151 GLY C O   1 
ATOM   1187 N N   . GLN C 3 32 ? 12.54394  6.32809   8.99592  1.000 133.14569 ? 152 GLN C N   1 
ATOM   1188 C CA  . GLN C 3 32 ? 12.74196  7.32393   7.94369  1.000 134.40303 ? 152 GLN C CA  1 
ATOM   1189 C C   . GLN C 3 32 ? 11.42405  7.72569   7.28184  1.000 136.52568 ? 152 GLN C C   1 
ATOM   1190 O O   . GLN C 3 32 ? 10.85813  6.97172   6.48893  1.000 137.95930 ? 152 GLN C O   1 
ATOM   1191 C CB  . GLN C 3 32 ? 13.71907  6.79340   6.88317  1.000 133.67819 ? 152 GLN C CB  1 
ATOM   1192 C CG  . GLN C 3 32 ? 15.06867  6.31850   7.42460  1.000 132.05896 ? 152 GLN C CG  1 
ATOM   1193 C CD  . GLN C 3 32 ? 15.86437  7.42591   8.09378  1.000 133.58669 ? 152 GLN C CD  1 
ATOM   1194 O OE1 . GLN C 3 32 ? 15.60964  7.77859   9.24298  1.000 131.55783 ? 152 GLN C OE1 1 
ATOM   1195 N NE2 . GLN C 3 32 ? 16.83670  7.97639   7.37550  1.000 134.56793 ? 152 GLN C NE2 1 
HETATM 1196 O O   . HOH D 4 .  ? 3.85892   -26.75680 14.58540 1.000 66.10970  ? 101 HOH A O   1 
HETATM 1197 O O   . HOH D 4 .  ? 8.32277   -24.60564 24.17172 1.000 55.74416  ? 102 HOH A O   1 
HETATM 1198 O O   . HOH D 4 .  ? 24.40135  -17.47275 17.12097 1.000 57.11554  ? 103 HOH A O   1 
HETATM 1199 O O   . HOH D 4 .  ? 14.79216  -19.10985 27.52411 1.000 56.68572  ? 104 HOH A O   1 
HETATM 1200 O O   . HOH D 4 .  ? -1.34280  -22.86945 15.31002 1.000 51.87515  ? 105 HOH A O   1 
HETATM 1201 O O   . HOH D 4 .  ? 8.37076   -21.63977 31.94242 1.000 58.42496  ? 106 HOH A O   1 
HETATM 1202 O O   . HOH D 4 .  ? 22.71144  -12.41009 21.56732 1.000 48.29302  ? 107 HOH A O   1 
HETATM 1203 O O   . HOH D 4 .  ? 5.78785   -12.79387 16.95489 1.000 57.62870  ? 108 HOH A O   1 
HETATM 1204 O O   . HOH D 4 .  ? 9.66329   -26.44019 10.20001 1.000 62.33543  ? 109 HOH A O   1 
HETATM 1205 O O   . HOH D 4 .  ? -3.23075  -21.11340 14.63437 1.000 51.00479  ? 110 HOH A O   1 
HETATM 1206 O O   . HOH D 4 .  ? 17.97650  -15.28373 28.24813 1.000 57.80751  ? 111 HOH A O   1 
HETATM 1207 O O   . HOH D 4 .  ? 6.19977   -21.60704 22.64547 1.000 52.53950  ? 112 HOH A O   1 
HETATM 1208 O O   . HOH D 4 .  ? 4.44319   -13.14500 14.19167 1.000 61.50785  ? 113 HOH A O   1 
HETATM 1209 O O   . HOH D 4 .  ? 10.58516  -19.63250 33.73417 1.000 59.64921  ? 114 HOH A O   1 
HETATM 1210 O O   . HOH D 4 .  ? 4.26419   -19.81274 26.66141 1.000 47.96482  ? 115 HOH A O   1 
HETATM 1211 O O   . HOH D 4 .  ? 11.03226  -11.03226 31.09175 0.50  58.99796  ? 116 HOH A O   1 
HETATM 1212 O O   . HOH D 4 .  ? 17.36620  -9.54621  26.95318 1.000 64.38013  ? 117 HOH A O   1 
HETATM 1213 O O   . HOH D 4 .  ? 17.59982  -18.03298 29.69634 1.000 65.67416  ? 118 HOH A O   1 
HETATM 1214 O O   . HOH D 4 .  ? -5.45437  -26.20348 9.09760  1.000 64.74501  ? 119 HOH A O   1 
HETATM 1215 O O   . HOH D 4 .  ? 14.60304  -24.01026 14.77248 1.000 67.61577  ? 120 HOH A O   1 
HETATM 1216 O O   . HOH D 4 .  ? -2.72326  -24.12240 13.23935 1.000 63.32010  ? 121 HOH A O   1 
HETATM 1217 O O   . HOH D 4 .  ? 20.93334  -8.13594  25.54384 1.000 56.57169  ? 122 HOH A O   1 
HETATM 1218 O O   . HOH D 4 .  ? 22.65543  -12.27585 29.00882 1.000 57.54296  ? 123 HOH A O   1 
HETATM 1219 O O   . HOH D 4 .  ? 15.82022  -16.12105 7.89787  1.000 56.91544  ? 124 HOH A O   1 
HETATM 1220 O O   . HOH D 4 .  ? 10.37544  -24.80510 8.28567  1.000 60.64336  ? 125 HOH A O   1 
HETATM 1221 O O   . HOH D 4 .  ? 8.01280   -26.06129 20.57266 1.000 63.31116  ? 126 HOH A O   1 
HETATM 1222 O O   . HOH D 4 .  ? 7.81334   -11.02005 33.07014 1.000 53.72274  ? 127 HOH A O   1 
HETATM 1223 O O   . HOH D 4 .  ? 12.85182  -7.85069  26.94373 1.000 58.68795  ? 128 HOH A O   1 
HETATM 1224 O O   . HOH D 4 .  ? 10.51113  -26.90907 16.21978 1.000 65.31584  ? 129 HOH A O   1 
HETATM 1225 O O   . HOH D 4 .  ? -5.45329  -24.27712 14.66088 1.000 61.46675  ? 130 HOH A O   1 
HETATM 1226 O O   . HOH D 4 .  ? 8.70970   -25.30046 31.21788 1.000 52.56003  ? 131 HOH A O   1 
HETATM 1227 O O   . HOH D 4 .  ? 5.42732   -21.72768 25.19362 1.000 51.63353  ? 132 HOH A O   1 
HETATM 1228 O O   . HOH D 4 .  ? -2.11339  -23.35104 17.64706 1.000 58.90615  ? 133 HOH A O   1 
HETATM 1229 O O   . HOH D 4 .  ? 15.34773  -24.67433 12.00330 1.000 68.34001  ? 134 HOH A O   1 
HETATM 1230 O O   . HOH D 4 .  ? 11.596    -16.413   33.916   1.000 63.62679  ? 135 HOH A O   1 
HETATM 1231 O O   . HOH E 4 .  ? -0.74586  -4.28850  19.80324 1.000 54.13950  ? 201 HOH B O   1 
HETATM 1232 O O   . HOH E 4 .  ? -7.71260  -21.84054 26.86183 1.000 50.89770  ? 202 HOH B O   1 
HETATM 1233 O O   . HOH E 4 .  ? 14.05839  -15.19816 6.01845  1.000 61.04165  ? 203 HOH B O   1 
HETATM 1234 O O   . HOH E 4 .  ? 7.69399   -15.93781 6.35785  1.000 67.10137  ? 204 HOH B O   1 
HETATM 1235 O O   . HOH E 4 .  ? -5.34787  -5.00078  26.83190 1.000 66.35904  ? 205 HOH B O   1 
HETATM 1236 O O   . HOH E 4 .  ? 2.28055   -7.83338  15.25668 1.000 52.55431  ? 206 HOH B O   1 
HETATM 1237 O O   . HOH E 4 .  ? -4.43943  -21.31686 33.54348 1.000 74.47439  ? 207 HOH B O   1 
HETATM 1238 O O   . HOH E 4 .  ? -2.48334  -23.91537 25.34663 1.000 59.22966  ? 208 HOH B O   1 
HETATM 1239 O O   . HOH E 4 .  ? -9.44987  -16.57389 23.38022 1.000 65.20204  ? 209 HOH B O   1 
HETATM 1240 O O   . HOH E 4 .  ? 7.29121   0.01112   11.12235 1.000 59.10710  ? 210 HOH B O   1 
HETATM 1241 O O   . HOH E 4 .  ? 4.79168   1.09413   22.44245 1.000 59.29280  ? 211 HOH B O   1 
HETATM 1242 O O   . HOH E 4 .  ? 18.36081  -14.03559 1.29352  1.000 62.86139  ? 212 HOH B O   1 
HETATM 1243 O O   . HOH E 4 .  ? 0.16548   -5.50042  12.22696 1.000 65.82132  ? 213 HOH B O   1 
HETATM 1244 O O   . HOH E 4 .  ? 20.27936  -16.78843 2.08136  1.000 64.53876  ? 214 HOH B O   1 
HETATM 1245 O O   . HOH E 4 .  ? 20.66255  -4.47289  12.85447 1.000 66.14789  ? 215 HOH B O   1 
HETATM 1246 O O   . HOH E 4 .  ? -0.02356  -21.42908 2.50756  1.000 68.29256  ? 216 HOH B O   1 
HETATM 1247 O O   . HOH E 4 .  ? -4.42191  -6.11075  28.98526 1.000 69.79834  ? 217 HOH B O   1 
HETATM 1248 O O   . HOH E 4 .  ? 22.090    -5.206    5.158    1.000 59.67597  ? 218 HOH B O   1 
HETATM 1249 O O   . HOH E 4 .  ? 12.05450  -15.07261 7.84184  1.000 63.09646  ? 219 HOH B O   1 
HETATM 1250 O O   . HOH E 4 .  ? 18.79333  -9.12616  17.87553 1.000 43.31279  ? 220 HOH B O   1 
HETATM 1251 O O   . HOH E 4 .  ? 17.27038  -13.93906 8.15503  1.000 55.59493  ? 221 HOH B O   1 
HETATM 1252 O O   . HOH E 4 .  ? 10.03899  -8.36822  3.90805  1.000 65.56703  ? 222 HOH B O   1 
HETATM 1253 O O   . HOH E 4 .  ? 22.24857  -16.56529 4.22792  1.000 56.41952  ? 223 HOH B O   1 
HETATM 1254 O O   . HOH E 4 .  ? 9.56806   -14.12370 6.73360  1.000 56.26147  ? 224 HOH B O   1 
HETATM 1255 O O   . HOH E 4 .  ? 18.32039  -8.53644  0.92665  1.000 56.25082  ? 225 HOH B O   1 
HETATM 1256 O O   . HOH E 4 .  ? -0.17997  -23.92100 3.47604  1.000 61.08655  ? 226 HOH B O   1 
HETATM 1257 O O   . HOH E 4 .  ? 5.20320   -10.41859 16.02938 1.000 51.57653  ? 227 HOH B O   1 
HETATM 1258 O O   . HOH E 4 .  ? -3.08938  -9.60120  37.08205 1.000 58.55973  ? 228 HOH B O   1 
HETATM 1259 O O   . HOH E 4 .  ? -2.77745  -26.61523 25.76059 1.000 71.98862  ? 229 HOH B O   1 
HETATM 1260 O O   . HOH E 4 .  ? 15.29618  -5.01490  25.60098 1.000 60.83264  ? 230 HOH B O   1 
HETATM 1261 O O   . HOH E 4 .  ? -1.08221  -2.04812  21.22002 1.000 54.72094  ? 231 HOH B O   1 
HETATM 1262 O O   . HOH E 4 .  ? -9.59108  -11.93616 35.58167 1.000 76.47916  ? 232 HOH B O   1 
HETATM 1263 O O   . HOH E 4 .  ? -7.79709  -13.94212 34.52205 1.000 65.41609  ? 233 HOH B O   1 
HETATM 1264 O O   . HOH E 4 .  ? -3.70262  -5.69632  35.32259 1.000 65.95299  ? 234 HOH B O   1 
HETATM 1265 O O   . HOH E 4 .  ? -3.86993  -20.17679 31.13872 1.000 63.63124  ? 235 HOH B O   1 
HETATM 1266 O O   . HOH E 4 .  ? 15.94662  -6.38249  23.14360 1.000 49.84692  ? 236 HOH B O   1 
HETATM 1267 O O   . HOH E 4 .  ? 16.70326  -15.44827 2.80825  1.000 67.10505  ? 237 HOH B O   1 
HETATM 1268 O O   . HOH E 4 .  ? -9.130    -9.978    18.204   1.000 71.98685  ? 238 HOH B O   1 
HETATM 1269 O O   . HOH E 4 .  ? 6.49377   2.63982   11.58826 1.000 78.11722  ? 239 HOH B O   1 
HETATM 1270 O O   . HOH E 4 .  ? 7.99880   -12.08095 8.15946  1.000 56.51921  ? 240 HOH B O   1 
HETATM 1271 O O   . HOH F 4 .  ? 1.39298   4.72577   20.54275 1.000 88.92899  ? 201 HOH C O   1 
HETATM 1272 O O   . HOH F 4 .  ? 17.26372  3.89894   8.85541  1.000 113.91849 ? 202 HOH C O   1 
HETATM 1273 O O   . HOH F 4 .  ? 3.17914   -21.15043 22.22823 1.000 57.70490  ? 203 HOH C O   1 
HETATM 1274 O O   . HOH F 4 .  ? -3.33205  -5.32792  18.83081 1.000 54.42692  ? 204 HOH C O   1 
HETATM 1275 O O   . HOH F 4 .  ? -6.93508  -6.09509  17.84696 1.000 63.07935  ? 205 HOH C O   1 
HETATM 1276 O O   . HOH F 4 .  ? 0.06344   0.46438   19.84094 1.000 62.15337  ? 206 HOH C O   1 
# 
