data_9KS7
# 
_entry.id   9KS7 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9KS7         pdb_00009ks7 10.2210/pdb9ks7/pdb 
WWPDB D_1300054188 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9KS7 
_pdbx_database_status.recvd_initial_deposition_date   2024-11-29 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              yamasaki@biken.osaka-u.ac.jp 
_pdbx_contact_author.name_first         Sho 
_pdbx_contact_author.name_last          Yamasaki 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-5184-6917 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Ito, T.'      1 ? 
'Nagae, M.'    2 ? 
'Yamasaki, S.' 3 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Immunogenetics 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           0093-7711 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            77 
_citation.language                  ? 
_citation.page_first                18 
_citation.page_last                 18 
_citation.title                     'Phylogenetic and structural insights into the origin of C-type lectin Mincle in vertebrates.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1007/s00251-025-01375-x 
_citation.pdbx_database_id_PubMed   40119899 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Ito, T.'      1 0000-0002-1408-7288 
primary 'Guenther, C.' 2 0000-0001-7915-1028 
primary 'Ishikawa, E.' 3 0000-0002-4922-6751 
primary 'Yabuki, T.'   4 ?                   
primary 'Nagae, M.'    5 0000-0002-5470-3807 
primary 'Nakatani, Y.' 6 0000-0001-7604-0242 
primary 'Yamasaki, S.' 7 0000-0002-5184-6917 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'C-type lectin domain-containing protein' 17412.408 4   ? ? ? 
'The sequence matches with Gene ID 105419054 (XP_029706534.1)' 
2 non-polymer syn GLYCEROL                                  92.094    4   ? ? ? ? 
3 non-polymer syn 'CALCIUM ION'                             40.078    8   ? ? ? ? 
4 water       nat water                                     18.015    402 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MNGTAEERNKFDKLDPYFQQGWFHFQKSLYYISSVKNTWHLSREYCLQEGADLAIINSRAEQAFLENFKMTLWIGLMEQR
SERTWRWVDGTPLTESYWSLGEPNNYEGRQEQCVEQIDREDKKGWNDLVCEFSNFYMCEKRIFP
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MNGTAEERNKFDKLDPYFQQGWFHFQKSLYYISSVKNTWHLSREYCLQEGADLAIINSRAEQAFLENFKMTLWIGLMEQR
SERTWRWVDGTPLTESYWSLGEPNNYEGRQEQCVEQIDREDKKGWNDLVCEFSNFYMCEKRIFP
;
_entity_poly.pdbx_strand_id                 A,B,E,G 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 GLYCEROL      GOL 
3 'CALCIUM ION' CA  
4 water         HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ASN n 
1 3   GLY n 
1 4   THR n 
1 5   ALA n 
1 6   GLU n 
1 7   GLU n 
1 8   ARG n 
1 9   ASN n 
1 10  LYS n 
1 11  PHE n 
1 12  ASP n 
1 13  LYS n 
1 14  LEU n 
1 15  ASP n 
1 16  PRO n 
1 17  TYR n 
1 18  PHE n 
1 19  GLN n 
1 20  GLN n 
1 21  GLY n 
1 22  TRP n 
1 23  PHE n 
1 24  HIS n 
1 25  PHE n 
1 26  GLN n 
1 27  LYS n 
1 28  SER n 
1 29  LEU n 
1 30  TYR n 
1 31  TYR n 
1 32  ILE n 
1 33  SER n 
1 34  SER n 
1 35  VAL n 
1 36  LYS n 
1 37  ASN n 
1 38  THR n 
1 39  TRP n 
1 40  HIS n 
1 41  LEU n 
1 42  SER n 
1 43  ARG n 
1 44  GLU n 
1 45  TYR n 
1 46  CYS n 
1 47  LEU n 
1 48  GLN n 
1 49  GLU n 
1 50  GLY n 
1 51  ALA n 
1 52  ASP n 
1 53  LEU n 
1 54  ALA n 
1 55  ILE n 
1 56  ILE n 
1 57  ASN n 
1 58  SER n 
1 59  ARG n 
1 60  ALA n 
1 61  GLU n 
1 62  GLN n 
1 63  ALA n 
1 64  PHE n 
1 65  LEU n 
1 66  GLU n 
1 67  ASN n 
1 68  PHE n 
1 69  LYS n 
1 70  MET n 
1 71  THR n 
1 72  LEU n 
1 73  TRP n 
1 74  ILE n 
1 75  GLY n 
1 76  LEU n 
1 77  MET n 
1 78  GLU n 
1 79  GLN n 
1 80  ARG n 
1 81  SER n 
1 82  GLU n 
1 83  ARG n 
1 84  THR n 
1 85  TRP n 
1 86  ARG n 
1 87  TRP n 
1 88  VAL n 
1 89  ASP n 
1 90  GLY n 
1 91  THR n 
1 92  PRO n 
1 93  LEU n 
1 94  THR n 
1 95  GLU n 
1 96  SER n 
1 97  TYR n 
1 98  TRP n 
1 99  SER n 
1 100 LEU n 
1 101 GLY n 
1 102 GLU n 
1 103 PRO n 
1 104 ASN n 
1 105 ASN n 
1 106 TYR n 
1 107 GLU n 
1 108 GLY n 
1 109 ARG n 
1 110 GLN n 
1 111 GLU n 
1 112 GLN n 
1 113 CYS n 
1 114 VAL n 
1 115 GLU n 
1 116 GLN n 
1 117 ILE n 
1 118 ASP n 
1 119 ARG n 
1 120 GLU n 
1 121 ASP n 
1 122 LYS n 
1 123 LYS n 
1 124 GLY n 
1 125 TRP n 
1 126 ASN n 
1 127 ASP n 
1 128 LEU n 
1 129 VAL n 
1 130 CYS n 
1 131 GLU n 
1 132 PHE n 
1 133 SER n 
1 134 ASN n 
1 135 PHE n 
1 136 TYR n 
1 137 MET n 
1 138 CYS n 
1 139 GLU n 
1 140 LYS n 
1 141 ARG n 
1 142 ILE n 
1 143 PHE n 
1 144 PRO n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   144 
_entity_src_gen.gene_src_common_name               torafugu 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Takifugu rubripes' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     31033 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ?                               'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ?                               'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ?                               'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                               'C4 H7 N O4'     133.103 
CA  non-polymer         . 'CALCIUM ION'   ?                               'Ca 2'           40.078  
CYS 'L-peptide linking' y CYSTEINE        ?                               'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ?                               'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                               'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ?                               'C2 H5 N O2'     75.067  
GOL non-polymer         . GLYCEROL        'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'       92.094  
HIS 'L-peptide linking' y HISTIDINE       ?                               'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ?                               'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ?                               'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ?                               'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ?                               'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ?                               'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ?                               'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ?                               'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ?                               'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ?                               'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ?                               'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ?                               'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ?                               'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   37  ?   ?   ?   A . n 
A 1 2   ASN 2   38  ?   ?   ?   A . n 
A 1 3   GLY 3   39  ?   ?   ?   A . n 
A 1 4   THR 4   40  ?   ?   ?   A . n 
A 1 5   ALA 5   41  ?   ?   ?   A . n 
A 1 6   GLU 6   42  ?   ?   ?   A . n 
A 1 7   GLU 7   43  ?   ?   ?   A . n 
A 1 8   ARG 8   44  ?   ?   ?   A . n 
A 1 9   ASN 9   45  45  ASN ASN A . n 
A 1 10  LYS 10  46  46  LYS LYS A . n 
A 1 11  PHE 11  47  47  PHE PHE A . n 
A 1 12  ASP 12  48  48  ASP ASP A . n 
A 1 13  LYS 13  49  49  LYS LYS A . n 
A 1 14  LEU 14  50  50  LEU LEU A . n 
A 1 15  ASP 15  51  51  ASP ASP A . n 
A 1 16  PRO 16  52  52  PRO PRO A . n 
A 1 17  TYR 17  53  53  TYR TYR A . n 
A 1 18  PHE 18  54  54  PHE PHE A . n 
A 1 19  GLN 19  55  55  GLN GLN A . n 
A 1 20  GLN 20  56  56  GLN GLN A . n 
A 1 21  GLY 21  57  57  GLY GLY A . n 
A 1 22  TRP 22  58  58  TRP TRP A . n 
A 1 23  PHE 23  59  59  PHE PHE A . n 
A 1 24  HIS 24  60  60  HIS HIS A . n 
A 1 25  PHE 25  61  61  PHE PHE A . n 
A 1 26  GLN 26  62  62  GLN GLN A . n 
A 1 27  LYS 27  63  63  LYS LYS A . n 
A 1 28  SER 28  64  64  SER SER A . n 
A 1 29  LEU 29  65  65  LEU LEU A . n 
A 1 30  TYR 30  66  66  TYR TYR A . n 
A 1 31  TYR 31  67  67  TYR TYR A . n 
A 1 32  ILE 32  68  68  ILE ILE A . n 
A 1 33  SER 33  69  69  SER SER A . n 
A 1 34  SER 34  70  70  SER SER A . n 
A 1 35  VAL 35  71  71  VAL VAL A . n 
A 1 36  LYS 36  72  72  LYS LYS A . n 
A 1 37  ASN 37  73  73  ASN ASN A . n 
A 1 38  THR 38  74  74  THR THR A . n 
A 1 39  TRP 39  75  75  TRP TRP A . n 
A 1 40  HIS 40  76  76  HIS HIS A . n 
A 1 41  LEU 41  77  77  LEU LEU A . n 
A 1 42  SER 42  78  78  SER SER A . n 
A 1 43  ARG 43  79  79  ARG ARG A . n 
A 1 44  GLU 44  80  80  GLU GLU A . n 
A 1 45  TYR 45  81  81  TYR TYR A . n 
A 1 46  CYS 46  82  82  CYS CYS A . n 
A 1 47  LEU 47  83  83  LEU LEU A . n 
A 1 48  GLN 48  84  84  GLN GLN A . n 
A 1 49  GLU 49  85  85  GLU GLU A . n 
A 1 50  GLY 50  86  86  GLY GLY A . n 
A 1 51  ALA 51  87  87  ALA ALA A . n 
A 1 52  ASP 52  88  88  ASP ASP A . n 
A 1 53  LEU 53  89  89  LEU LEU A . n 
A 1 54  ALA 54  90  90  ALA ALA A . n 
A 1 55  ILE 55  91  91  ILE ILE A . n 
A 1 56  ILE 56  92  92  ILE ILE A . n 
A 1 57  ASN 57  93  93  ASN ASN A . n 
A 1 58  SER 58  94  94  SER SER A . n 
A 1 59  ARG 59  95  95  ARG ARG A . n 
A 1 60  ALA 60  96  96  ALA ALA A . n 
A 1 61  GLU 61  97  97  GLU GLU A . n 
A 1 62  GLN 62  98  98  GLN GLN A . n 
A 1 63  ALA 63  99  99  ALA ALA A . n 
A 1 64  PHE 64  100 100 PHE PHE A . n 
A 1 65  LEU 65  101 101 LEU LEU A . n 
A 1 66  GLU 66  102 102 GLU GLU A . n 
A 1 67  ASN 67  103 103 ASN ASN A . n 
A 1 68  PHE 68  104 104 PHE PHE A . n 
A 1 69  LYS 69  105 105 LYS LYS A . n 
A 1 70  MET 70  106 106 MET MET A . n 
A 1 71  THR 71  107 107 THR THR A . n 
A 1 72  LEU 72  108 108 LEU LEU A . n 
A 1 73  TRP 73  109 109 TRP TRP A . n 
A 1 74  ILE 74  110 110 ILE ILE A . n 
A 1 75  GLY 75  111 111 GLY GLY A . n 
A 1 76  LEU 76  112 112 LEU LEU A . n 
A 1 77  MET 77  113 113 MET MET A . n 
A 1 78  GLU 78  114 114 GLU GLU A . n 
A 1 79  GLN 79  115 115 GLN GLN A . n 
A 1 80  ARG 80  116 116 ARG ARG A . n 
A 1 81  SER 81  117 117 SER SER A . n 
A 1 82  GLU 82  118 118 GLU GLU A . n 
A 1 83  ARG 83  119 119 ARG ARG A . n 
A 1 84  THR 84  120 120 THR THR A . n 
A 1 85  TRP 85  121 121 TRP TRP A . n 
A 1 86  ARG 86  122 122 ARG ARG A . n 
A 1 87  TRP 87  123 123 TRP TRP A . n 
A 1 88  VAL 88  124 124 VAL VAL A . n 
A 1 89  ASP 89  125 125 ASP ASP A . n 
A 1 90  GLY 90  126 126 GLY GLY A . n 
A 1 91  THR 91  127 127 THR THR A . n 
A 1 92  PRO 92  128 128 PRO PRO A . n 
A 1 93  LEU 93  129 129 LEU LEU A . n 
A 1 94  THR 94  130 130 THR THR A . n 
A 1 95  GLU 95  131 131 GLU GLU A . n 
A 1 96  SER 96  132 132 SER SER A . n 
A 1 97  TYR 97  133 133 TYR TYR A . n 
A 1 98  TRP 98  134 134 TRP TRP A . n 
A 1 99  SER 99  135 135 SER SER A . n 
A 1 100 LEU 100 136 136 LEU LEU A . n 
A 1 101 GLY 101 137 137 GLY GLY A . n 
A 1 102 GLU 102 138 138 GLU GLU A . n 
A 1 103 PRO 103 139 139 PRO PRO A . n 
A 1 104 ASN 104 140 140 ASN ASN A . n 
A 1 105 ASN 105 141 141 ASN ASN A . n 
A 1 106 TYR 106 142 142 TYR TYR A . n 
A 1 107 GLU 107 143 143 GLU GLU A . n 
A 1 108 GLY 108 144 144 GLY GLY A . n 
A 1 109 ARG 109 145 145 ARG ARG A . n 
A 1 110 GLN 110 146 146 GLN GLN A . n 
A 1 111 GLU 111 147 147 GLU GLU A . n 
A 1 112 GLN 112 148 148 GLN GLN A . n 
A 1 113 CYS 113 149 149 CYS CYS A . n 
A 1 114 VAL 114 150 150 VAL VAL A . n 
A 1 115 GLU 115 151 151 GLU GLU A . n 
A 1 116 GLN 116 152 152 GLN GLN A . n 
A 1 117 ILE 117 153 153 ILE ILE A . n 
A 1 118 ASP 118 154 154 ASP ASP A . n 
A 1 119 ARG 119 155 155 ARG ARG A . n 
A 1 120 GLU 120 156 156 GLU GLU A . n 
A 1 121 ASP 121 157 157 ASP ASP A . n 
A 1 122 LYS 122 158 158 LYS LYS A . n 
A 1 123 LYS 123 159 159 LYS LYS A . n 
A 1 124 GLY 124 160 160 GLY GLY A . n 
A 1 125 TRP 125 161 161 TRP TRP A . n 
A 1 126 ASN 126 162 162 ASN ASN A . n 
A 1 127 ASP 127 163 163 ASP ASP A . n 
A 1 128 LEU 128 164 164 LEU LEU A . n 
A 1 129 VAL 129 165 165 VAL VAL A . n 
A 1 130 CYS 130 166 166 CYS CYS A . n 
A 1 131 GLU 131 167 167 GLU GLU A . n 
A 1 132 PHE 132 168 168 PHE PHE A . n 
A 1 133 SER 133 169 169 SER SER A . n 
A 1 134 ASN 134 170 170 ASN ASN A . n 
A 1 135 PHE 135 171 171 PHE PHE A . n 
A 1 136 TYR 136 172 172 TYR TYR A . n 
A 1 137 MET 137 173 173 MET MET A . n 
A 1 138 CYS 138 174 174 CYS CYS A . n 
A 1 139 GLU 139 175 175 GLU GLU A . n 
A 1 140 LYS 140 176 176 LYS LYS A . n 
A 1 141 ARG 141 177 177 ARG ARG A . n 
A 1 142 ILE 142 178 178 ILE ILE A . n 
A 1 143 PHE 143 179 179 PHE PHE A . n 
A 1 144 PRO 144 180 180 PRO PRO A . n 
B 1 1   MET 1   37  ?   ?   ?   B . n 
B 1 2   ASN 2   38  ?   ?   ?   B . n 
B 1 3   GLY 3   39  ?   ?   ?   B . n 
B 1 4   THR 4   40  ?   ?   ?   B . n 
B 1 5   ALA 5   41  ?   ?   ?   B . n 
B 1 6   GLU 6   42  ?   ?   ?   B . n 
B 1 7   GLU 7   43  ?   ?   ?   B . n 
B 1 8   ARG 8   44  ?   ?   ?   B . n 
B 1 9   ASN 9   45  ?   ?   ?   B . n 
B 1 10  LYS 10  46  ?   ?   ?   B . n 
B 1 11  PHE 11  47  47  PHE PHE B . n 
B 1 12  ASP 12  48  48  ASP ASP B . n 
B 1 13  LYS 13  49  49  LYS LYS B . n 
B 1 14  LEU 14  50  50  LEU LEU B . n 
B 1 15  ASP 15  51  51  ASP ASP B . n 
B 1 16  PRO 16  52  52  PRO PRO B . n 
B 1 17  TYR 17  53  53  TYR TYR B . n 
B 1 18  PHE 18  54  54  PHE PHE B . n 
B 1 19  GLN 19  55  55  GLN GLN B . n 
B 1 20  GLN 20  56  56  GLN GLN B . n 
B 1 21  GLY 21  57  57  GLY GLY B . n 
B 1 22  TRP 22  58  58  TRP TRP B . n 
B 1 23  PHE 23  59  59  PHE PHE B . n 
B 1 24  HIS 24  60  60  HIS HIS B . n 
B 1 25  PHE 25  61  61  PHE PHE B . n 
B 1 26  GLN 26  62  62  GLN GLN B . n 
B 1 27  LYS 27  63  63  LYS LYS B . n 
B 1 28  SER 28  64  64  SER SER B . n 
B 1 29  LEU 29  65  65  LEU LEU B . n 
B 1 30  TYR 30  66  66  TYR TYR B . n 
B 1 31  TYR 31  67  67  TYR TYR B . n 
B 1 32  ILE 32  68  68  ILE ILE B . n 
B 1 33  SER 33  69  69  SER SER B . n 
B 1 34  SER 34  70  70  SER SER B . n 
B 1 35  VAL 35  71  71  VAL VAL B . n 
B 1 36  LYS 36  72  72  LYS LYS B . n 
B 1 37  ASN 37  73  73  ASN ASN B . n 
B 1 38  THR 38  74  74  THR THR B . n 
B 1 39  TRP 39  75  75  TRP TRP B . n 
B 1 40  HIS 40  76  76  HIS HIS B . n 
B 1 41  LEU 41  77  77  LEU LEU B . n 
B 1 42  SER 42  78  78  SER SER B . n 
B 1 43  ARG 43  79  79  ARG ARG B . n 
B 1 44  GLU 44  80  80  GLU GLU B . n 
B 1 45  TYR 45  81  81  TYR TYR B . n 
B 1 46  CYS 46  82  82  CYS CYS B . n 
B 1 47  LEU 47  83  83  LEU LEU B . n 
B 1 48  GLN 48  84  84  GLN GLN B . n 
B 1 49  GLU 49  85  85  GLU GLU B . n 
B 1 50  GLY 50  86  86  GLY GLY B . n 
B 1 51  ALA 51  87  87  ALA ALA B . n 
B 1 52  ASP 52  88  88  ASP ASP B . n 
B 1 53  LEU 53  89  89  LEU LEU B . n 
B 1 54  ALA 54  90  90  ALA ALA B . n 
B 1 55  ILE 55  91  91  ILE ILE B . n 
B 1 56  ILE 56  92  92  ILE ILE B . n 
B 1 57  ASN 57  93  93  ASN ASN B . n 
B 1 58  SER 58  94  94  SER SER B . n 
B 1 59  ARG 59  95  95  ARG ARG B . n 
B 1 60  ALA 60  96  96  ALA ALA B . n 
B 1 61  GLU 61  97  97  GLU GLU B . n 
B 1 62  GLN 62  98  98  GLN GLN B . n 
B 1 63  ALA 63  99  99  ALA ALA B . n 
B 1 64  PHE 64  100 100 PHE PHE B . n 
B 1 65  LEU 65  101 101 LEU LEU B . n 
B 1 66  GLU 66  102 102 GLU GLU B . n 
B 1 67  ASN 67  103 103 ASN ASN B . n 
B 1 68  PHE 68  104 104 PHE PHE B . n 
B 1 69  LYS 69  105 105 LYS LYS B . n 
B 1 70  MET 70  106 106 MET MET B . n 
B 1 71  THR 71  107 107 THR THR B . n 
B 1 72  LEU 72  108 108 LEU LEU B . n 
B 1 73  TRP 73  109 109 TRP TRP B . n 
B 1 74  ILE 74  110 110 ILE ILE B . n 
B 1 75  GLY 75  111 111 GLY GLY B . n 
B 1 76  LEU 76  112 112 LEU LEU B . n 
B 1 77  MET 77  113 113 MET MET B . n 
B 1 78  GLU 78  114 114 GLU GLU B . n 
B 1 79  GLN 79  115 115 GLN GLN B . n 
B 1 80  ARG 80  116 116 ARG ARG B . n 
B 1 81  SER 81  117 117 SER SER B . n 
B 1 82  GLU 82  118 118 GLU GLU B . n 
B 1 83  ARG 83  119 119 ARG ARG B . n 
B 1 84  THR 84  120 120 THR THR B . n 
B 1 85  TRP 85  121 121 TRP TRP B . n 
B 1 86  ARG 86  122 122 ARG ARG B . n 
B 1 87  TRP 87  123 123 TRP TRP B . n 
B 1 88  VAL 88  124 124 VAL VAL B . n 
B 1 89  ASP 89  125 125 ASP ASP B . n 
B 1 90  GLY 90  126 126 GLY GLY B . n 
B 1 91  THR 91  127 127 THR THR B . n 
B 1 92  PRO 92  128 128 PRO PRO B . n 
B 1 93  LEU 93  129 129 LEU LEU B . n 
B 1 94  THR 94  130 130 THR THR B . n 
B 1 95  GLU 95  131 131 GLU GLU B . n 
B 1 96  SER 96  132 132 SER SER B . n 
B 1 97  TYR 97  133 133 TYR TYR B . n 
B 1 98  TRP 98  134 134 TRP TRP B . n 
B 1 99  SER 99  135 135 SER SER B . n 
B 1 100 LEU 100 136 136 LEU LEU B . n 
B 1 101 GLY 101 137 137 GLY GLY B . n 
B 1 102 GLU 102 138 138 GLU GLU B . n 
B 1 103 PRO 103 139 139 PRO PRO B . n 
B 1 104 ASN 104 140 140 ASN ASN B . n 
B 1 105 ASN 105 141 141 ASN ASN B . n 
B 1 106 TYR 106 142 142 TYR TYR B . n 
B 1 107 GLU 107 143 143 GLU GLU B . n 
B 1 108 GLY 108 144 144 GLY GLY B . n 
B 1 109 ARG 109 145 145 ARG ARG B . n 
B 1 110 GLN 110 146 146 GLN GLN B . n 
B 1 111 GLU 111 147 147 GLU GLU B . n 
B 1 112 GLN 112 148 148 GLN GLN B . n 
B 1 113 CYS 113 149 149 CYS CYS B . n 
B 1 114 VAL 114 150 150 VAL VAL B . n 
B 1 115 GLU 115 151 151 GLU GLU B . n 
B 1 116 GLN 116 152 152 GLN GLN B . n 
B 1 117 ILE 117 153 153 ILE ILE B . n 
B 1 118 ASP 118 154 154 ASP ASP B . n 
B 1 119 ARG 119 155 155 ARG ARG B . n 
B 1 120 GLU 120 156 156 GLU GLU B . n 
B 1 121 ASP 121 157 157 ASP ASP B . n 
B 1 122 LYS 122 158 158 LYS LYS B . n 
B 1 123 LYS 123 159 159 LYS LYS B . n 
B 1 124 GLY 124 160 160 GLY GLY B . n 
B 1 125 TRP 125 161 161 TRP TRP B . n 
B 1 126 ASN 126 162 162 ASN ASN B . n 
B 1 127 ASP 127 163 163 ASP ASP B . n 
B 1 128 LEU 128 164 164 LEU LEU B . n 
B 1 129 VAL 129 165 165 VAL VAL B . n 
B 1 130 CYS 130 166 166 CYS CYS B . n 
B 1 131 GLU 131 167 167 GLU GLU B . n 
B 1 132 PHE 132 168 168 PHE PHE B . n 
B 1 133 SER 133 169 169 SER SER B . n 
B 1 134 ASN 134 170 170 ASN ASN B . n 
B 1 135 PHE 135 171 171 PHE PHE B . n 
B 1 136 TYR 136 172 172 TYR TYR B . n 
B 1 137 MET 137 173 173 MET MET B . n 
B 1 138 CYS 138 174 174 CYS CYS B . n 
B 1 139 GLU 139 175 175 GLU GLU B . n 
B 1 140 LYS 140 176 176 LYS LYS B . n 
B 1 141 ARG 141 177 177 ARG ARG B . n 
B 1 142 ILE 142 178 178 ILE ILE B . n 
B 1 143 PHE 143 179 179 PHE PHE B . n 
B 1 144 PRO 144 180 180 PRO PRO B . n 
C 1 1   MET 1   37  ?   ?   ?   E . n 
C 1 2   ASN 2   38  ?   ?   ?   E . n 
C 1 3   GLY 3   39  ?   ?   ?   E . n 
C 1 4   THR 4   40  ?   ?   ?   E . n 
C 1 5   ALA 5   41  ?   ?   ?   E . n 
C 1 6   GLU 6   42  ?   ?   ?   E . n 
C 1 7   GLU 7   43  ?   ?   ?   E . n 
C 1 8   ARG 8   44  ?   ?   ?   E . n 
C 1 9   ASN 9   45  ?   ?   ?   E . n 
C 1 10  LYS 10  46  ?   ?   ?   E . n 
C 1 11  PHE 11  47  47  PHE PHE E . n 
C 1 12  ASP 12  48  48  ASP ASP E . n 
C 1 13  LYS 13  49  49  LYS LYS E . n 
C 1 14  LEU 14  50  50  LEU LEU E . n 
C 1 15  ASP 15  51  51  ASP ASP E . n 
C 1 16  PRO 16  52  52  PRO PRO E . n 
C 1 17  TYR 17  53  53  TYR TYR E . n 
C 1 18  PHE 18  54  54  PHE PHE E . n 
C 1 19  GLN 19  55  55  GLN GLN E . n 
C 1 20  GLN 20  56  56  GLN GLN E . n 
C 1 21  GLY 21  57  57  GLY GLY E . n 
C 1 22  TRP 22  58  58  TRP TRP E . n 
C 1 23  PHE 23  59  59  PHE PHE E . n 
C 1 24  HIS 24  60  60  HIS HIS E . n 
C 1 25  PHE 25  61  61  PHE PHE E . n 
C 1 26  GLN 26  62  62  GLN GLN E . n 
C 1 27  LYS 27  63  63  LYS LYS E . n 
C 1 28  SER 28  64  64  SER SER E . n 
C 1 29  LEU 29  65  65  LEU LEU E . n 
C 1 30  TYR 30  66  66  TYR TYR E . n 
C 1 31  TYR 31  67  67  TYR TYR E . n 
C 1 32  ILE 32  68  68  ILE ILE E . n 
C 1 33  SER 33  69  69  SER SER E . n 
C 1 34  SER 34  70  70  SER SER E . n 
C 1 35  VAL 35  71  71  VAL VAL E . n 
C 1 36  LYS 36  72  72  LYS LYS E . n 
C 1 37  ASN 37  73  73  ASN ASN E . n 
C 1 38  THR 38  74  74  THR THR E . n 
C 1 39  TRP 39  75  75  TRP TRP E . n 
C 1 40  HIS 40  76  76  HIS HIS E . n 
C 1 41  LEU 41  77  77  LEU LEU E . n 
C 1 42  SER 42  78  78  SER SER E . n 
C 1 43  ARG 43  79  79  ARG ARG E . n 
C 1 44  GLU 44  80  80  GLU GLU E . n 
C 1 45  TYR 45  81  81  TYR TYR E . n 
C 1 46  CYS 46  82  82  CYS CYS E . n 
C 1 47  LEU 47  83  83  LEU LEU E . n 
C 1 48  GLN 48  84  84  GLN GLN E . n 
C 1 49  GLU 49  85  85  GLU GLU E . n 
C 1 50  GLY 50  86  86  GLY GLY E . n 
C 1 51  ALA 51  87  87  ALA ALA E . n 
C 1 52  ASP 52  88  88  ASP ASP E . n 
C 1 53  LEU 53  89  89  LEU LEU E . n 
C 1 54  ALA 54  90  90  ALA ALA E . n 
C 1 55  ILE 55  91  91  ILE ILE E . n 
C 1 56  ILE 56  92  92  ILE ILE E . n 
C 1 57  ASN 57  93  93  ASN ASN E . n 
C 1 58  SER 58  94  94  SER SER E . n 
C 1 59  ARG 59  95  95  ARG ARG E . n 
C 1 60  ALA 60  96  96  ALA ALA E . n 
C 1 61  GLU 61  97  97  GLU GLU E . n 
C 1 62  GLN 62  98  98  GLN GLN E . n 
C 1 63  ALA 63  99  99  ALA ALA E . n 
C 1 64  PHE 64  100 100 PHE PHE E . n 
C 1 65  LEU 65  101 101 LEU LEU E . n 
C 1 66  GLU 66  102 102 GLU GLU E . n 
C 1 67  ASN 67  103 103 ASN ASN E . n 
C 1 68  PHE 68  104 104 PHE PHE E . n 
C 1 69  LYS 69  105 105 LYS LYS E . n 
C 1 70  MET 70  106 106 MET MET E . n 
C 1 71  THR 71  107 107 THR THR E . n 
C 1 72  LEU 72  108 108 LEU LEU E . n 
C 1 73  TRP 73  109 109 TRP TRP E . n 
C 1 74  ILE 74  110 110 ILE ILE E . n 
C 1 75  GLY 75  111 111 GLY GLY E . n 
C 1 76  LEU 76  112 112 LEU LEU E . n 
C 1 77  MET 77  113 113 MET MET E . n 
C 1 78  GLU 78  114 114 GLU GLU E . n 
C 1 79  GLN 79  115 115 GLN GLN E . n 
C 1 80  ARG 80  116 116 ARG ARG E . n 
C 1 81  SER 81  117 117 SER SER E . n 
C 1 82  GLU 82  118 118 GLU GLU E . n 
C 1 83  ARG 83  119 119 ARG ARG E . n 
C 1 84  THR 84  120 120 THR THR E . n 
C 1 85  TRP 85  121 121 TRP TRP E . n 
C 1 86  ARG 86  122 122 ARG ARG E . n 
C 1 87  TRP 87  123 123 TRP TRP E . n 
C 1 88  VAL 88  124 124 VAL VAL E . n 
C 1 89  ASP 89  125 125 ASP ASP E . n 
C 1 90  GLY 90  126 126 GLY GLY E . n 
C 1 91  THR 91  127 127 THR THR E . n 
C 1 92  PRO 92  128 128 PRO PRO E . n 
C 1 93  LEU 93  129 129 LEU LEU E . n 
C 1 94  THR 94  130 130 THR THR E . n 
C 1 95  GLU 95  131 131 GLU GLU E . n 
C 1 96  SER 96  132 132 SER SER E . n 
C 1 97  TYR 97  133 133 TYR TYR E . n 
C 1 98  TRP 98  134 134 TRP TRP E . n 
C 1 99  SER 99  135 135 SER SER E . n 
C 1 100 LEU 100 136 136 LEU LEU E . n 
C 1 101 GLY 101 137 137 GLY GLY E . n 
C 1 102 GLU 102 138 138 GLU GLU E . n 
C 1 103 PRO 103 139 139 PRO PRO E . n 
C 1 104 ASN 104 140 140 ASN ASN E . n 
C 1 105 ASN 105 141 141 ASN ASN E . n 
C 1 106 TYR 106 142 142 TYR TYR E . n 
C 1 107 GLU 107 143 143 GLU GLU E . n 
C 1 108 GLY 108 144 144 GLY GLY E . n 
C 1 109 ARG 109 145 145 ARG ARG E . n 
C 1 110 GLN 110 146 146 GLN GLN E . n 
C 1 111 GLU 111 147 147 GLU GLU E . n 
C 1 112 GLN 112 148 148 GLN GLN E . n 
C 1 113 CYS 113 149 149 CYS CYS E . n 
C 1 114 VAL 114 150 150 VAL VAL E . n 
C 1 115 GLU 115 151 151 GLU GLU E . n 
C 1 116 GLN 116 152 152 GLN GLN E . n 
C 1 117 ILE 117 153 153 ILE ILE E . n 
C 1 118 ASP 118 154 154 ASP ASP E . n 
C 1 119 ARG 119 155 155 ARG ARG E . n 
C 1 120 GLU 120 156 156 GLU GLU E . n 
C 1 121 ASP 121 157 157 ASP ASP E . n 
C 1 122 LYS 122 158 158 LYS LYS E . n 
C 1 123 LYS 123 159 159 LYS LYS E . n 
C 1 124 GLY 124 160 160 GLY GLY E . n 
C 1 125 TRP 125 161 161 TRP TRP E . n 
C 1 126 ASN 126 162 162 ASN ASN E . n 
C 1 127 ASP 127 163 163 ASP ASP E . n 
C 1 128 LEU 128 164 164 LEU LEU E . n 
C 1 129 VAL 129 165 165 VAL VAL E . n 
C 1 130 CYS 130 166 166 CYS CYS E . n 
C 1 131 GLU 131 167 167 GLU GLU E . n 
C 1 132 PHE 132 168 168 PHE PHE E . n 
C 1 133 SER 133 169 169 SER SER E . n 
C 1 134 ASN 134 170 170 ASN ASN E . n 
C 1 135 PHE 135 171 171 PHE PHE E . n 
C 1 136 TYR 136 172 172 TYR TYR E . n 
C 1 137 MET 137 173 173 MET MET E . n 
C 1 138 CYS 138 174 174 CYS CYS E . n 
C 1 139 GLU 139 175 175 GLU GLU E . n 
C 1 140 LYS 140 176 176 LYS LYS E . n 
C 1 141 ARG 141 177 177 ARG ARG E . n 
C 1 142 ILE 142 178 178 ILE ILE E . n 
C 1 143 PHE 143 179 179 PHE PHE E . n 
C 1 144 PRO 144 180 180 PRO PRO E . n 
D 1 1   MET 1   37  ?   ?   ?   G . n 
D 1 2   ASN 2   38  ?   ?   ?   G . n 
D 1 3   GLY 3   39  ?   ?   ?   G . n 
D 1 4   THR 4   40  ?   ?   ?   G . n 
D 1 5   ALA 5   41  ?   ?   ?   G . n 
D 1 6   GLU 6   42  ?   ?   ?   G . n 
D 1 7   GLU 7   43  ?   ?   ?   G . n 
D 1 8   ARG 8   44  ?   ?   ?   G . n 
D 1 9   ASN 9   45  ?   ?   ?   G . n 
D 1 10  LYS 10  46  46  LYS LYS G . n 
D 1 11  PHE 11  47  47  PHE PHE G . n 
D 1 12  ASP 12  48  48  ASP ASP G . n 
D 1 13  LYS 13  49  49  LYS LYS G . n 
D 1 14  LEU 14  50  50  LEU LEU G . n 
D 1 15  ASP 15  51  51  ASP ASP G . n 
D 1 16  PRO 16  52  52  PRO PRO G . n 
D 1 17  TYR 17  53  53  TYR TYR G . n 
D 1 18  PHE 18  54  54  PHE PHE G . n 
D 1 19  GLN 19  55  55  GLN GLN G . n 
D 1 20  GLN 20  56  56  GLN GLN G . n 
D 1 21  GLY 21  57  57  GLY GLY G . n 
D 1 22  TRP 22  58  58  TRP TRP G . n 
D 1 23  PHE 23  59  59  PHE PHE G . n 
D 1 24  HIS 24  60  60  HIS HIS G . n 
D 1 25  PHE 25  61  61  PHE PHE G . n 
D 1 26  GLN 26  62  62  GLN GLN G . n 
D 1 27  LYS 27  63  63  LYS LYS G . n 
D 1 28  SER 28  64  64  SER SER G . n 
D 1 29  LEU 29  65  65  LEU LEU G . n 
D 1 30  TYR 30  66  66  TYR TYR G . n 
D 1 31  TYR 31  67  67  TYR TYR G . n 
D 1 32  ILE 32  68  68  ILE ILE G . n 
D 1 33  SER 33  69  69  SER SER G . n 
D 1 34  SER 34  70  70  SER SER G . n 
D 1 35  VAL 35  71  71  VAL VAL G . n 
D 1 36  LYS 36  72  72  LYS LYS G . n 
D 1 37  ASN 37  73  73  ASN ASN G . n 
D 1 38  THR 38  74  74  THR THR G . n 
D 1 39  TRP 39  75  75  TRP TRP G . n 
D 1 40  HIS 40  76  76  HIS HIS G . n 
D 1 41  LEU 41  77  77  LEU LEU G . n 
D 1 42  SER 42  78  78  SER SER G . n 
D 1 43  ARG 43  79  79  ARG ARG G . n 
D 1 44  GLU 44  80  80  GLU GLU G . n 
D 1 45  TYR 45  81  81  TYR TYR G . n 
D 1 46  CYS 46  82  82  CYS CYS G . n 
D 1 47  LEU 47  83  83  LEU LEU G . n 
D 1 48  GLN 48  84  84  GLN GLN G . n 
D 1 49  GLU 49  85  85  GLU GLU G . n 
D 1 50  GLY 50  86  86  GLY GLY G . n 
D 1 51  ALA 51  87  87  ALA ALA G . n 
D 1 52  ASP 52  88  88  ASP ASP G . n 
D 1 53  LEU 53  89  89  LEU LEU G . n 
D 1 54  ALA 54  90  90  ALA ALA G . n 
D 1 55  ILE 55  91  91  ILE ILE G . n 
D 1 56  ILE 56  92  92  ILE ILE G . n 
D 1 57  ASN 57  93  93  ASN ASN G . n 
D 1 58  SER 58  94  94  SER SER G . n 
D 1 59  ARG 59  95  95  ARG ARG G . n 
D 1 60  ALA 60  96  96  ALA ALA G . n 
D 1 61  GLU 61  97  97  GLU GLU G . n 
D 1 62  GLN 62  98  98  GLN GLN G . n 
D 1 63  ALA 63  99  99  ALA ALA G . n 
D 1 64  PHE 64  100 100 PHE PHE G . n 
D 1 65  LEU 65  101 101 LEU LEU G . n 
D 1 66  GLU 66  102 102 GLU GLU G . n 
D 1 67  ASN 67  103 103 ASN ASN G . n 
D 1 68  PHE 68  104 104 PHE PHE G . n 
D 1 69  LYS 69  105 105 LYS LYS G . n 
D 1 70  MET 70  106 106 MET MET G . n 
D 1 71  THR 71  107 107 THR THR G . n 
D 1 72  LEU 72  108 108 LEU LEU G . n 
D 1 73  TRP 73  109 109 TRP TRP G . n 
D 1 74  ILE 74  110 110 ILE ILE G . n 
D 1 75  GLY 75  111 111 GLY GLY G . n 
D 1 76  LEU 76  112 112 LEU LEU G . n 
D 1 77  MET 77  113 113 MET MET G . n 
D 1 78  GLU 78  114 114 GLU GLU G . n 
D 1 79  GLN 79  115 115 GLN GLN G . n 
D 1 80  ARG 80  116 116 ARG ARG G . n 
D 1 81  SER 81  117 117 SER SER G . n 
D 1 82  GLU 82  118 118 GLU GLU G . n 
D 1 83  ARG 83  119 119 ARG ARG G . n 
D 1 84  THR 84  120 120 THR THR G . n 
D 1 85  TRP 85  121 121 TRP TRP G . n 
D 1 86  ARG 86  122 122 ARG ARG G . n 
D 1 87  TRP 87  123 123 TRP TRP G . n 
D 1 88  VAL 88  124 124 VAL VAL G . n 
D 1 89  ASP 89  125 125 ASP ASP G . n 
D 1 90  GLY 90  126 126 GLY GLY G . n 
D 1 91  THR 91  127 127 THR THR G . n 
D 1 92  PRO 92  128 128 PRO PRO G . n 
D 1 93  LEU 93  129 129 LEU LEU G . n 
D 1 94  THR 94  130 130 THR THR G . n 
D 1 95  GLU 95  131 131 GLU GLU G . n 
D 1 96  SER 96  132 132 SER SER G . n 
D 1 97  TYR 97  133 133 TYR TYR G . n 
D 1 98  TRP 98  134 134 TRP TRP G . n 
D 1 99  SER 99  135 135 SER SER G . n 
D 1 100 LEU 100 136 136 LEU LEU G . n 
D 1 101 GLY 101 137 137 GLY GLY G . n 
D 1 102 GLU 102 138 138 GLU GLU G . n 
D 1 103 PRO 103 139 139 PRO PRO G . n 
D 1 104 ASN 104 140 140 ASN ASN G . n 
D 1 105 ASN 105 141 141 ASN ASN G . n 
D 1 106 TYR 106 142 142 TYR TYR G . n 
D 1 107 GLU 107 143 143 GLU GLU G . n 
D 1 108 GLY 108 144 144 GLY GLY G . n 
D 1 109 ARG 109 145 145 ARG ARG G . n 
D 1 110 GLN 110 146 146 GLN GLN G . n 
D 1 111 GLU 111 147 147 GLU GLU G . n 
D 1 112 GLN 112 148 148 GLN GLN G . n 
D 1 113 CYS 113 149 149 CYS CYS G . n 
D 1 114 VAL 114 150 150 VAL VAL G . n 
D 1 115 GLU 115 151 151 GLU GLU G . n 
D 1 116 GLN 116 152 152 GLN GLN G . n 
D 1 117 ILE 117 153 153 ILE ILE G . n 
D 1 118 ASP 118 154 154 ASP ASP G . n 
D 1 119 ARG 119 155 155 ARG ARG G . n 
D 1 120 GLU 120 156 156 GLU GLU G . n 
D 1 121 ASP 121 157 157 ASP ASP G . n 
D 1 122 LYS 122 158 158 LYS LYS G . n 
D 1 123 LYS 123 159 159 LYS LYS G . n 
D 1 124 GLY 124 160 160 GLY GLY G . n 
D 1 125 TRP 125 161 161 TRP TRP G . n 
D 1 126 ASN 126 162 162 ASN ASN G . n 
D 1 127 ASP 127 163 163 ASP ASP G . n 
D 1 128 LEU 128 164 164 LEU LEU G . n 
D 1 129 VAL 129 165 165 VAL VAL G . n 
D 1 130 CYS 130 166 166 CYS CYS G . n 
D 1 131 GLU 131 167 167 GLU GLU G . n 
D 1 132 PHE 132 168 168 PHE PHE G . n 
D 1 133 SER 133 169 169 SER SER G . n 
D 1 134 ASN 134 170 170 ASN ASN G . n 
D 1 135 PHE 135 171 171 PHE PHE G . n 
D 1 136 TYR 136 172 172 TYR TYR G . n 
D 1 137 MET 137 173 173 MET MET G . n 
D 1 138 CYS 138 174 174 CYS CYS G . n 
D 1 139 GLU 139 175 175 GLU GLU G . n 
D 1 140 LYS 140 176 176 LYS LYS G . n 
D 1 141 ARG 141 177 177 ARG ARG G . n 
D 1 142 ILE 142 178 178 ILE ILE G . n 
D 1 143 PHE 143 179 179 PHE PHE G . n 
D 1 144 PRO 144 180 180 PRO PRO G . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 CA  ? ? CA  ? ? 'SUBJECT OF INVESTIGATION' ? 
2 GOL ? ? GOL ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
E 2 GOL 1   201 238 GOL GOL A . 
F 3 CA  1   202 1   CA  CA  A . 
G 3 CA  1   203 2   CA  CA  A . 
H 2 GOL 1   201 238 GOL GOL B . 
I 3 CA  1   202 3   CA  CA  B . 
J 3 CA  1   203 4   CA  CA  B . 
K 2 GOL 1   201 238 GOL GOL E . 
L 3 CA  1   202 5   CA  CA  E . 
M 3 CA  1   203 6   CA  CA  E . 
N 2 GOL 1   201 238 GOL GOL G . 
O 3 CA  1   202 7   CA  CA  G . 
P 3 CA  1   203 8   CA  CA  G . 
Q 4 HOH 1   301 338 HOH HOH A . 
Q 4 HOH 2   302 223 HOH HOH A . 
Q 4 HOH 3   303 68  HOH HOH A . 
Q 4 HOH 4   304 266 HOH HOH A . 
Q 4 HOH 5   305 269 HOH HOH A . 
Q 4 HOH 6   306 369 HOH HOH A . 
Q 4 HOH 7   307 29  HOH HOH A . 
Q 4 HOH 8   308 328 HOH HOH A . 
Q 4 HOH 9   309 34  HOH HOH A . 
Q 4 HOH 10  310 287 HOH HOH A . 
Q 4 HOH 11  311 49  HOH HOH A . 
Q 4 HOH 12  312 39  HOH HOH A . 
Q 4 HOH 13  313 80  HOH HOH A . 
Q 4 HOH 14  314 69  HOH HOH A . 
Q 4 HOH 15  315 263 HOH HOH A . 
Q 4 HOH 16  316 51  HOH HOH A . 
Q 4 HOH 17  317 160 HOH HOH A . 
Q 4 HOH 18  318 41  HOH HOH A . 
Q 4 HOH 19  319 57  HOH HOH A . 
Q 4 HOH 20  320 47  HOH HOH A . 
Q 4 HOH 21  321 71  HOH HOH A . 
Q 4 HOH 22  322 301 HOH HOH A . 
Q 4 HOH 23  323 45  HOH HOH A . 
Q 4 HOH 24  324 46  HOH HOH A . 
Q 4 HOH 25  325 33  HOH HOH A . 
Q 4 HOH 26  326 290 HOH HOH A . 
Q 4 HOH 27  327 256 HOH HOH A . 
Q 4 HOH 28  328 297 HOH HOH A . 
Q 4 HOH 29  329 340 HOH HOH A . 
Q 4 HOH 30  330 210 HOH HOH A . 
Q 4 HOH 31  331 63  HOH HOH A . 
Q 4 HOH 32  332 277 HOH HOH A . 
Q 4 HOH 33  333 376 HOH HOH A . 
Q 4 HOH 34  334 155 HOH HOH A . 
Q 4 HOH 35  335 253 HOH HOH A . 
Q 4 HOH 36  336 247 HOH HOH A . 
Q 4 HOH 37  337 42  HOH HOH A . 
Q 4 HOH 38  338 339 HOH HOH A . 
Q 4 HOH 39  339 380 HOH HOH A . 
Q 4 HOH 40  340 162 HOH HOH A . 
Q 4 HOH 41  341 214 HOH HOH A . 
Q 4 HOH 42  342 32  HOH HOH A . 
Q 4 HOH 43  343 66  HOH HOH A . 
Q 4 HOH 44  344 37  HOH HOH A . 
Q 4 HOH 45  345 61  HOH HOH A . 
Q 4 HOH 46  346 67  HOH HOH A . 
Q 4 HOH 47  347 56  HOH HOH A . 
Q 4 HOH 48  348 232 HOH HOH A . 
Q 4 HOH 49  349 321 HOH HOH A . 
Q 4 HOH 50  350 1   HOH HOH A . 
Q 4 HOH 51  351 375 HOH HOH A . 
Q 4 HOH 52  352 78  HOH HOH A . 
Q 4 HOH 53  353 159 HOH HOH A . 
Q 4 HOH 54  354 333 HOH HOH A . 
Q 4 HOH 55  355 377 HOH HOH A . 
Q 4 HOH 56  356 258 HOH HOH A . 
Q 4 HOH 57  357 274 HOH HOH A . 
Q 4 HOH 58  358 31  HOH HOH A . 
Q 4 HOH 59  359 260 HOH HOH A . 
Q 4 HOH 60  360 40  HOH HOH A . 
Q 4 HOH 61  361 77  HOH HOH A . 
Q 4 HOH 62  362 161 HOH HOH A . 
Q 4 HOH 63  363 59  HOH HOH A . 
Q 4 HOH 64  364 70  HOH HOH A . 
Q 4 HOH 65  365 220 HOH HOH A . 
Q 4 HOH 66  366 30  HOH HOH A . 
Q 4 HOH 67  367 379 HOH HOH A . 
Q 4 HOH 68  368 76  HOH HOH A . 
Q 4 HOH 69  369 54  HOH HOH A . 
Q 4 HOH 70  370 249 HOH HOH A . 
Q 4 HOH 71  371 254 HOH HOH A . 
Q 4 HOH 72  372 79  HOH HOH A . 
Q 4 HOH 73  373 48  HOH HOH A . 
Q 4 HOH 74  374 208 HOH HOH A . 
Q 4 HOH 75  375 224 HOH HOH A . 
Q 4 HOH 76  376 35  HOH HOH A . 
Q 4 HOH 77  377 44  HOH HOH A . 
Q 4 HOH 78  378 217 HOH HOH A . 
Q 4 HOH 79  379 245 HOH HOH A . 
Q 4 HOH 80  380 73  HOH HOH A . 
Q 4 HOH 81  381 241 HOH HOH A . 
Q 4 HOH 82  382 378 HOH HOH A . 
Q 4 HOH 83  383 358 HOH HOH A . 
Q 4 HOH 84  384 60  HOH HOH A . 
Q 4 HOH 85  385 372 HOH HOH A . 
Q 4 HOH 86  386 36  HOH HOH A . 
Q 4 HOH 87  387 43  HOH HOH A . 
Q 4 HOH 88  388 308 HOH HOH A . 
Q 4 HOH 89  389 21  HOH HOH A . 
Q 4 HOH 90  390 52  HOH HOH A . 
Q 4 HOH 91  391 311 HOH HOH A . 
Q 4 HOH 92  392 341 HOH HOH A . 
Q 4 HOH 93  393 351 HOH HOH A . 
Q 4 HOH 94  394 347 HOH HOH A . 
Q 4 HOH 95  395 353 HOH HOH A . 
Q 4 HOH 96  396 74  HOH HOH A . 
Q 4 HOH 97  397 50  HOH HOH A . 
Q 4 HOH 98  398 53  HOH HOH A . 
Q 4 HOH 99  399 373 HOH HOH A . 
Q 4 HOH 100 400 367 HOH HOH A . 
R 4 HOH 1   301 300 HOH HOH B . 
R 4 HOH 2   302 326 HOH HOH B . 
R 4 HOH 3   303 387 HOH HOH B . 
R 4 HOH 4   304 112 HOH HOH B . 
R 4 HOH 5   305 262 HOH HOH B . 
R 4 HOH 6   306 244 HOH HOH B . 
R 4 HOH 7   307 298 HOH HOH B . 
R 4 HOH 8   308 267 HOH HOH B . 
R 4 HOH 9   309 109 HOH HOH B . 
R 4 HOH 10  310 219 HOH HOH B . 
R 4 HOH 11  311 324 HOH HOH B . 
R 4 HOH 12  312 391 HOH HOH B . 
R 4 HOH 13  313 110 HOH HOH B . 
R 4 HOH 14  314 96  HOH HOH B . 
R 4 HOH 15  315 27  HOH HOH B . 
R 4 HOH 16  316 295 HOH HOH B . 
R 4 HOH 17  317 209 HOH HOH B . 
R 4 HOH 18  318 6   HOH HOH B . 
R 4 HOH 19  319 26  HOH HOH B . 
R 4 HOH 20  320 133 HOH HOH B . 
R 4 HOH 21  321 90  HOH HOH B . 
R 4 HOH 22  322 91  HOH HOH B . 
R 4 HOH 23  323 318 HOH HOH B . 
R 4 HOH 24  324 310 HOH HOH B . 
R 4 HOH 25  325 327 HOH HOH B . 
R 4 HOH 26  326 111 HOH HOH B . 
R 4 HOH 27  327 383 HOH HOH B . 
R 4 HOH 28  328 83  HOH HOH B . 
R 4 HOH 29  329 7   HOH HOH B . 
R 4 HOH 30  330 307 HOH HOH B . 
R 4 HOH 31  331 285 HOH HOH B . 
R 4 HOH 32  332 250 HOH HOH B . 
R 4 HOH 33  333 107 HOH HOH B . 
R 4 HOH 34  334 389 HOH HOH B . 
R 4 HOH 35  335 108 HOH HOH B . 
R 4 HOH 36  336 125 HOH HOH B . 
R 4 HOH 37  337 98  HOH HOH B . 
R 4 HOH 38  338 84  HOH HOH B . 
R 4 HOH 39  339 304 HOH HOH B . 
R 4 HOH 40  340 354 HOH HOH B . 
R 4 HOH 41  341 128 HOH HOH B . 
R 4 HOH 42  342 101 HOH HOH B . 
R 4 HOH 43  343 97  HOH HOH B . 
R 4 HOH 44  344 105 HOH HOH B . 
R 4 HOH 45  345 139 HOH HOH B . 
R 4 HOH 46  346 230 HOH HOH B . 
R 4 HOH 47  347 335 HOH HOH B . 
R 4 HOH 48  348 206 HOH HOH B . 
R 4 HOH 49  349 137 HOH HOH B . 
R 4 HOH 50  350 315 HOH HOH B . 
R 4 HOH 51  351 5   HOH HOH B . 
R 4 HOH 52  352 228 HOH HOH B . 
R 4 HOH 53  353 319 HOH HOH B . 
R 4 HOH 54  354 114 HOH HOH B . 
R 4 HOH 55  355 131 HOH HOH B . 
R 4 HOH 56  356 106 HOH HOH B . 
R 4 HOH 57  357 92  HOH HOH B . 
R 4 HOH 58  358 132 HOH HOH B . 
R 4 HOH 59  359 3   HOH HOH B . 
R 4 HOH 60  360 294 HOH HOH B . 
R 4 HOH 61  361 234 HOH HOH B . 
R 4 HOH 62  362 305 HOH HOH B . 
R 4 HOH 63  363 222 HOH HOH B . 
R 4 HOH 64  364 140 HOH HOH B . 
R 4 HOH 65  365 384 HOH HOH B . 
R 4 HOH 66  366 314 HOH HOH B . 
R 4 HOH 67  367 135 HOH HOH B . 
R 4 HOH 68  368 382 HOH HOH B . 
R 4 HOH 69  369 130 HOH HOH B . 
R 4 HOH 70  370 408 HOH HOH B . 
R 4 HOH 71  371 296 HOH HOH B . 
R 4 HOH 72  372 293 HOH HOH B . 
R 4 HOH 73  373 363 HOH HOH B . 
R 4 HOH 74  374 323 HOH HOH B . 
R 4 HOH 75  375 93  HOH HOH B . 
R 4 HOH 76  376 113 HOH HOH B . 
R 4 HOH 77  377 392 HOH HOH B . 
R 4 HOH 78  378 386 HOH HOH B . 
R 4 HOH 79  379 226 HOH HOH B . 
R 4 HOH 80  380 265 HOH HOH B . 
R 4 HOH 81  381 94  HOH HOH B . 
R 4 HOH 82  382 349 HOH HOH B . 
R 4 HOH 83  383 2   HOH HOH B . 
R 4 HOH 84  384 136 HOH HOH B . 
R 4 HOH 85  385 227 HOH HOH B . 
R 4 HOH 86  386 117 HOH HOH B . 
R 4 HOH 87  387 134 HOH HOH B . 
R 4 HOH 88  388 85  HOH HOH B . 
R 4 HOH 89  389 359 HOH HOH B . 
R 4 HOH 90  390 4   HOH HOH B . 
R 4 HOH 91  391 99  HOH HOH B . 
R 4 HOH 92  392 272 HOH HOH B . 
R 4 HOH 93  393 239 HOH HOH B . 
R 4 HOH 94  394 303 HOH HOH B . 
R 4 HOH 95  395 95  HOH HOH B . 
R 4 HOH 96  396 25  HOH HOH B . 
R 4 HOH 97  397 390 HOH HOH B . 
R 4 HOH 98  398 334 HOH HOH B . 
R 4 HOH 99  399 129 HOH HOH B . 
R 4 HOH 100 400 322 HOH HOH B . 
R 4 HOH 101 401 306 HOH HOH B . 
R 4 HOH 102 402 280 HOH HOH B . 
S 4 HOH 1   301 175 HOH HOH E . 
S 4 HOH 2   302 147 HOH HOH E . 
S 4 HOH 3   303 58  HOH HOH E . 
S 4 HOH 4   304 374 HOH HOH E . 
S 4 HOH 5   305 174 HOH HOH E . 
S 4 HOH 6   306 152 HOH HOH E . 
S 4 HOH 7   307 261 HOH HOH E . 
S 4 HOH 8   308 355 HOH HOH E . 
S 4 HOH 9   309 64  HOH HOH E . 
S 4 HOH 10  310 62  HOH HOH E . 
S 4 HOH 11  311 407 HOH HOH E . 
S 4 HOH 12  312 166 HOH HOH E . 
S 4 HOH 13  313 176 HOH HOH E . 
S 4 HOH 14  314 151 HOH HOH E . 
S 4 HOH 15  315 164 HOH HOH E . 
S 4 HOH 16  316 163 HOH HOH E . 
S 4 HOH 17  317 20  HOH HOH E . 
S 4 HOH 18  318 275 HOH HOH E . 
S 4 HOH 19  319 11  HOH HOH E . 
S 4 HOH 20  320 264 HOH HOH E . 
S 4 HOH 21  321 168 HOH HOH E . 
S 4 HOH 22  322 148 HOH HOH E . 
S 4 HOH 23  323 213 HOH HOH E . 
S 4 HOH 24  324 237 HOH HOH E . 
S 4 HOH 25  325 14  HOH HOH E . 
S 4 HOH 26  326 177 HOH HOH E . 
S 4 HOH 27  327 167 HOH HOH E . 
S 4 HOH 28  328 178 HOH HOH E . 
S 4 HOH 29  329 158 HOH HOH E . 
S 4 HOH 30  330 146 HOH HOH E . 
S 4 HOH 31  331 13  HOH HOH E . 
S 4 HOH 32  332 156 HOH HOH E . 
S 4 HOH 33  333 12  HOH HOH E . 
S 4 HOH 34  334 394 HOH HOH E . 
S 4 HOH 35  335 144 HOH HOH E . 
S 4 HOH 36  336 9   HOH HOH E . 
S 4 HOH 37  337 65  HOH HOH E . 
S 4 HOH 38  338 257 HOH HOH E . 
S 4 HOH 39  339 362 HOH HOH E . 
S 4 HOH 40  340 221 HOH HOH E . 
S 4 HOH 41  341 143 HOH HOH E . 
S 4 HOH 42  342 22  HOH HOH E . 
S 4 HOH 43  343 332 HOH HOH E . 
S 4 HOH 44  344 238 HOH HOH E . 
S 4 HOH 45  345 172 HOH HOH E . 
S 4 HOH 46  346 279 HOH HOH E . 
S 4 HOH 47  347 344 HOH HOH E . 
S 4 HOH 48  348 150 HOH HOH E . 
S 4 HOH 49  349 243 HOH HOH E . 
S 4 HOH 50  350 278 HOH HOH E . 
S 4 HOH 51  351 330 HOH HOH E . 
S 4 HOH 52  352 153 HOH HOH E . 
S 4 HOH 53  353 342 HOH HOH E . 
S 4 HOH 54  354 292 HOH HOH E . 
S 4 HOH 55  355 173 HOH HOH E . 
S 4 HOH 56  356 28  HOH HOH E . 
S 4 HOH 57  357 72  HOH HOH E . 
S 4 HOH 58  358 149 HOH HOH E . 
S 4 HOH 59  359 268 HOH HOH E . 
S 4 HOH 60  360 141 HOH HOH E . 
S 4 HOH 61  361 320 HOH HOH E . 
S 4 HOH 62  362 336 HOH HOH E . 
S 4 HOH 63  363 23  HOH HOH E . 
S 4 HOH 64  364 273 HOH HOH E . 
S 4 HOH 65  365 270 HOH HOH E . 
S 4 HOH 66  366 180 HOH HOH E . 
S 4 HOH 67  367 317 HOH HOH E . 
S 4 HOH 68  368 281 HOH HOH E . 
S 4 HOH 69  369 170 HOH HOH E . 
S 4 HOH 70  370 157 HOH HOH E . 
S 4 HOH 71  371 218 HOH HOH E . 
S 4 HOH 72  372 142 HOH HOH E . 
S 4 HOH 73  373 165 HOH HOH E . 
S 4 HOH 74  374 181 HOH HOH E . 
S 4 HOH 75  375 371 HOH HOH E . 
S 4 HOH 76  376 252 HOH HOH E . 
S 4 HOH 77  377 259 HOH HOH E . 
S 4 HOH 78  378 288 HOH HOH E . 
S 4 HOH 79  379 145 HOH HOH E . 
S 4 HOH 80  380 240 HOH HOH E . 
S 4 HOH 81  381 212 HOH HOH E . 
S 4 HOH 82  382 365 HOH HOH E . 
S 4 HOH 83  383 289 HOH HOH E . 
S 4 HOH 84  384 350 HOH HOH E . 
S 4 HOH 85  385 171 HOH HOH E . 
S 4 HOH 86  386 235 HOH HOH E . 
S 4 HOH 87  387 284 HOH HOH E . 
S 4 HOH 88  388 395 HOH HOH E . 
S 4 HOH 89  389 38  HOH HOH E . 
S 4 HOH 90  390 154 HOH HOH E . 
S 4 HOH 91  391 348 HOH HOH E . 
S 4 HOH 92  392 8   HOH HOH E . 
S 4 HOH 93  393 361 HOH HOH E . 
S 4 HOH 94  394 370 HOH HOH E . 
S 4 HOH 95  395 309 HOH HOH E . 
S 4 HOH 96  396 55  HOH HOH E . 
S 4 HOH 97  397 346 HOH HOH E . 
S 4 HOH 98  398 393 HOH HOH E . 
S 4 HOH 99  399 291 HOH HOH E . 
S 4 HOH 100 400 283 HOH HOH E . 
S 4 HOH 101 401 179 HOH HOH E . 
S 4 HOH 102 402 352 HOH HOH E . 
S 4 HOH 103 403 10  HOH HOH E . 
S 4 HOH 104 404 345 HOH HOH E . 
S 4 HOH 105 405 356 HOH HOH E . 
S 4 HOH 106 406 169 HOH HOH E . 
T 4 HOH 1   301 399 HOH HOH G . 
T 4 HOH 2   302 118 HOH HOH G . 
T 4 HOH 3   303 104 HOH HOH G . 
T 4 HOH 4   304 205 HOH HOH G . 
T 4 HOH 5   305 122 HOH HOH G . 
T 4 HOH 6   306 121 HOH HOH G . 
T 4 HOH 7   307 398 HOH HOH G . 
T 4 HOH 8   308 282 HOH HOH G . 
T 4 HOH 9   309 192 HOH HOH G . 
T 4 HOH 10  310 203 HOH HOH G . 
T 4 HOH 11  311 215 HOH HOH G . 
T 4 HOH 12  312 19  HOH HOH G . 
T 4 HOH 13  313 201 HOH HOH G . 
T 4 HOH 14  314 402 HOH HOH G . 
T 4 HOH 15  315 271 HOH HOH G . 
T 4 HOH 16  316 403 HOH HOH G . 
T 4 HOH 17  317 100 HOH HOH G . 
T 4 HOH 18  318 202 HOH HOH G . 
T 4 HOH 19  319 102 HOH HOH G . 
T 4 HOH 20  320 127 HOH HOH G . 
T 4 HOH 21  321 182 HOH HOH G . 
T 4 HOH 22  322 195 HOH HOH G . 
T 4 HOH 23  323 229 HOH HOH G . 
T 4 HOH 24  324 286 HOH HOH G . 
T 4 HOH 25  325 86  HOH HOH G . 
T 4 HOH 26  326 236 HOH HOH G . 
T 4 HOH 27  327 231 HOH HOH G . 
T 4 HOH 28  328 200 HOH HOH G . 
T 4 HOH 29  329 302 HOH HOH G . 
T 4 HOH 30  330 88  HOH HOH G . 
T 4 HOH 31  331 81  HOH HOH G . 
T 4 HOH 32  332 198 HOH HOH G . 
T 4 HOH 33  333 138 HOH HOH G . 
T 4 HOH 34  334 103 HOH HOH G . 
T 4 HOH 35  335 24  HOH HOH G . 
T 4 HOH 36  336 299 HOH HOH G . 
T 4 HOH 37  337 276 HOH HOH G . 
T 4 HOH 38  338 204 HOH HOH G . 
T 4 HOH 39  339 89  HOH HOH G . 
T 4 HOH 40  340 329 HOH HOH G . 
T 4 HOH 41  341 18  HOH HOH G . 
T 4 HOH 42  342 233 HOH HOH G . 
T 4 HOH 43  343 225 HOH HOH G . 
T 4 HOH 44  344 185 HOH HOH G . 
T 4 HOH 45  345 251 HOH HOH G . 
T 4 HOH 46  346 248 HOH HOH G . 
T 4 HOH 47  347 400 HOH HOH G . 
T 4 HOH 48  348 405 HOH HOH G . 
T 4 HOH 49  349 15  HOH HOH G . 
T 4 HOH 50  350 115 HOH HOH G . 
T 4 HOH 51  351 124 HOH HOH G . 
T 4 HOH 52  352 191 HOH HOH G . 
T 4 HOH 53  353 87  HOH HOH G . 
T 4 HOH 54  354 188 HOH HOH G . 
T 4 HOH 55  355 207 HOH HOH G . 
T 4 HOH 56  356 316 HOH HOH G . 
T 4 HOH 57  357 242 HOH HOH G . 
T 4 HOH 58  358 189 HOH HOH G . 
T 4 HOH 59  359 123 HOH HOH G . 
T 4 HOH 60  360 255 HOH HOH G . 
T 4 HOH 61  361 404 HOH HOH G . 
T 4 HOH 62  362 193 HOH HOH G . 
T 4 HOH 63  363 313 HOH HOH G . 
T 4 HOH 64  364 368 HOH HOH G . 
T 4 HOH 65  365 216 HOH HOH G . 
T 4 HOH 66  366 184 HOH HOH G . 
T 4 HOH 67  367 197 HOH HOH G . 
T 4 HOH 68  368 194 HOH HOH G . 
T 4 HOH 69  369 190 HOH HOH G . 
T 4 HOH 70  370 357 HOH HOH G . 
T 4 HOH 71  371 183 HOH HOH G . 
T 4 HOH 72  372 119 HOH HOH G . 
T 4 HOH 73  373 401 HOH HOH G . 
T 4 HOH 74  374 343 HOH HOH G . 
T 4 HOH 75  375 16  HOH HOH G . 
T 4 HOH 76  376 406 HOH HOH G . 
T 4 HOH 77  377 116 HOH HOH G . 
T 4 HOH 78  378 120 HOH HOH G . 
T 4 HOH 79  379 17  HOH HOH G . 
T 4 HOH 80  380 75  HOH HOH G . 
T 4 HOH 81  381 360 HOH HOH G . 
T 4 HOH 82  382 312 HOH HOH G . 
T 4 HOH 83  383 337 HOH HOH G . 
T 4 HOH 84  384 82  HOH HOH G . 
T 4 HOH 85  385 397 HOH HOH G . 
T 4 HOH 86  386 186 HOH HOH G . 
T 4 HOH 87  387 381 HOH HOH G . 
T 4 HOH 88  388 366 HOH HOH G . 
T 4 HOH 89  389 126 HOH HOH G . 
T 4 HOH 90  390 331 HOH HOH G . 
T 4 HOH 91  391 196 HOH HOH G . 
T 4 HOH 92  392 364 HOH HOH G . 
T 4 HOH 93  393 199 HOH HOH G . 
T 4 HOH 94  394 187 HOH HOH G . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.21_5207 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .         2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .         3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? MOLREP  ? ? ? .         4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   94.431 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9KS7 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     51.531 
_cell.length_a_esd                 ? 
_cell.length_b                     72.371 
_cell.length_b_esd                 ? 
_cell.length_c                     88.646 
_cell.length_c_esd                 ? 
_cell.volume                       329603.853 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9KS7 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            'P 2yb' 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9KS7 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.37 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          48.02 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              8.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1M tris (pH8.5), 0.2M sodium chloride, 25% (w/v) polyethylene glycol (PEG) 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     95 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-02-12 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9800 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PHOTON FACTORY BEAMLINE BL-17A' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9800 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL-17A 
_diffrn_source.pdbx_synchrotron_site       'Photon Factory' 
# 
_reflns.B_iso_Wilson_estimate                          18.07 
_reflns.entry_id                                       9KS7 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.70 
_reflns.d_resolution_low                               45.99 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     71262 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.7 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          11.0 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                0.038 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.997 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.060 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.70 
_reflns_shell.d_res_low                                     1.73 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           3.0 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3757 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               2.9 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               0.227 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.928 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.5 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.322 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               24.81 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9KS7 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.70 
_refine.ls_d_res_low                             44.19 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     71183 
_refine.ls_number_reflns_R_free                  3601 
_refine.ls_number_reflns_R_work                  67582 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.56 
_refine.ls_percent_reflns_R_free                 5.06 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1745 
_refine.ls_R_factor_R_free                       0.1965 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1734 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.98 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 20.5063 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1531 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.70 
_refine_hist.d_res_low                        44.19 
_refine_hist.number_atoms_solvent             402 
_refine_hist.number_atoms_total               5052 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4618 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         32 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0086 ? 4848 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.0726 ? 6563 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0701 ? 630  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0102 ? 847  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 6.9415 ? 631  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.70 1.72  . . 151 2582 99.13 . . . . 0.2427 . . . . . . . . . . . 0.2531 
'X-RAY DIFFRACTION' 1.72 1.75  . . 139 2556 99.93 . . . . 0.2377 . . . . . . . . . . . 0.2890 
'X-RAY DIFFRACTION' 1.75 1.77  . . 160 2629 99.86 . . . . 0.2104 . . . . . . . . . . . 0.2020 
'X-RAY DIFFRACTION' 1.77 1.80  . . 131 2559 99.93 . . . . 0.1992 . . . . . . . . . . . 0.2280 
'X-RAY DIFFRACTION' 1.80 1.83  . . 153 2593 99.96 . . . . 0.1878 . . . . . . . . . . . 0.2339 
'X-RAY DIFFRACTION' 1.83 1.86  . . 133 2611 99.75 . . . . 0.1805 . . . . . . . . . . . 0.1968 
'X-RAY DIFFRACTION' 1.86 1.89  . . 153 2580 99.74 . . . . 0.1775 . . . . . . . . . . . 0.2064 
'X-RAY DIFFRACTION' 1.89 1.92  . . 122 2585 99.71 . . . . 0.1865 . . . . . . . . . . . 0.2242 
'X-RAY DIFFRACTION' 1.92 1.96  . . 128 2597 99.78 . . . . 0.1722 . . . . . . . . . . . 0.1969 
'X-RAY DIFFRACTION' 1.96 2.00  . . 130 2625 99.86 . . . . 0.1670 . . . . . . . . . . . 0.1913 
'X-RAY DIFFRACTION' 2.00 2.04  . . 139 2574 99.85 . . . . 0.1669 . . . . . . . . . . . 0.1943 
'X-RAY DIFFRACTION' 2.04 2.09  . . 138 2581 99.96 . . . . 0.1715 . . . . . . . . . . . 0.2238 
'X-RAY DIFFRACTION' 2.09 2.14  . . 150 2632 99.89 . . . . 0.1671 . . . . . . . . . . . 0.2001 
'X-RAY DIFFRACTION' 2.14 2.20  . . 157 2577 99.82 . . . . 0.1598 . . . . . . . . . . . 0.2119 
'X-RAY DIFFRACTION' 2.20 2.26  . . 140 2589 99.56 . . . . 0.1643 . . . . . . . . . . . 0.2117 
'X-RAY DIFFRACTION' 2.26 2.34  . . 157 2600 99.71 . . . . 0.1646 . . . . . . . . . . . 0.2053 
'X-RAY DIFFRACTION' 2.34 2.42  . . 125 2593 99.67 . . . . 0.1723 . . . . . . . . . . . 0.1803 
'X-RAY DIFFRACTION' 2.42 2.52  . . 131 2604 99.71 . . . . 0.1781 . . . . . . . . . . . 0.2186 
'X-RAY DIFFRACTION' 2.52 2.63  . . 130 2590 99.67 . . . . 0.1812 . . . . . . . . . . . 0.2108 
'X-RAY DIFFRACTION' 2.63 2.77  . . 125 2640 99.57 . . . . 0.1787 . . . . . . . . . . . 0.2109 
'X-RAY DIFFRACTION' 2.77 2.94  . . 130 2604 99.45 . . . . 0.1742 . . . . . . . . . . . 0.2136 
'X-RAY DIFFRACTION' 2.95 3.17  . . 150 2605 99.49 . . . . 0.1859 . . . . . . . . . . . 0.2248 
'X-RAY DIFFRACTION' 3.17 3.49  . . 152 2571 99.13 . . . . 0.1734 . . . . . . . . . . . 0.1661 
'X-RAY DIFFRACTION' 3.49 4.00  . . 131 2621 98.99 . . . . 0.1569 . . . . . . . . . . . 0.1716 
'X-RAY DIFFRACTION' 4.00 5.03  . . 125 2607 98.24 . . . . 0.1485 . . . . . . . . . . . 0.1566 
'X-RAY DIFFRACTION' 5.04 44.19 . . 121 2677 98.35 . . . . 0.1824 . . . . . . . . . . . 0.1901 
# 
_struct.entry_id                     9KS7 
_struct.title                        'Crystal structure of T. rubripes Mincle with glycerol' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9KS7 
_struct_keywords.text            'C-type lectin, ectodomain, Carbohydrate recognition doamin, IMMUNE SYSTEM' 
_struct_keywords.pdbx_keywords   'IMMUNE SYSTEM' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 1 ? 
D N N 1 ? 
E N N 2 ? 
F N N 3 ? 
G N N 3 ? 
H N N 2 ? 
I N N 3 ? 
J N N 3 ? 
K N N 2 ? 
L N N 3 ? 
M N N 3 ? 
N N N 2 ? 
O N N 3 ? 
P N N 3 ? 
Q N N 4 ? 
R N N 4 ? 
S N N 4 ? 
T N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A3B5KEF3_TAKRU 
_struct_ref.pdbx_db_accession          A0A3B5KEF3 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;NGTAEERNTFDKLDPYFKRGWFHFQKSLYYISSVKNTWHLSREYCLQEGADLAIINSRAEQAFLENFKMTLWIGLMEQRS
ERTWRWVDGTPLTESYWSLGEPNNYEGRQEQCVEQVDREDKKGWNDLVCEFSNFYMCEKRIFP
;
_struct_ref.pdbx_align_begin           52 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9KS7 A 2 ? 144 ? A0A3B5KEF3 52 ? 194 ? 38 180 
2 1 9KS7 B 2 ? 144 ? A0A3B5KEF3 52 ? 194 ? 38 180 
3 1 9KS7 E 2 ? 144 ? A0A3B5KEF3 52 ? 194 ? 38 180 
4 1 9KS7 G 2 ? 144 ? A0A3B5KEF3 52 ? 194 ? 38 180 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9KS7 MET A 1   ? UNP A0A3B5KEF3 ?   ?   'initiating methionine' 37  1  
1 9KS7 LYS A 10  ? UNP A0A3B5KEF3 THR 60  conflict                46  2  
1 9KS7 GLN A 19  ? UNP A0A3B5KEF3 LYS 69  conflict                55  3  
1 9KS7 GLN A 20  ? UNP A0A3B5KEF3 ARG 70  conflict                56  4  
1 9KS7 ILE A 117 ? UNP A0A3B5KEF3 VAL 167 conflict                153 5  
2 9KS7 MET B 1   ? UNP A0A3B5KEF3 ?   ?   'initiating methionine' 37  6  
2 9KS7 LYS B 10  ? UNP A0A3B5KEF3 THR 60  conflict                46  7  
2 9KS7 GLN B 19  ? UNP A0A3B5KEF3 LYS 69  conflict                55  8  
2 9KS7 GLN B 20  ? UNP A0A3B5KEF3 ARG 70  conflict                56  9  
2 9KS7 ILE B 117 ? UNP A0A3B5KEF3 VAL 167 conflict                153 10 
3 9KS7 MET E 1   ? UNP A0A3B5KEF3 ?   ?   'initiating methionine' 37  11 
3 9KS7 LYS E 10  ? UNP A0A3B5KEF3 THR 60  conflict                46  12 
3 9KS7 GLN E 19  ? UNP A0A3B5KEF3 LYS 69  conflict                55  13 
3 9KS7 GLN E 20  ? UNP A0A3B5KEF3 ARG 70  conflict                56  14 
3 9KS7 ILE E 117 ? UNP A0A3B5KEF3 VAL 167 conflict                153 15 
4 9KS7 MET G 1   ? UNP A0A3B5KEF3 ?   ?   'initiating methionine' 37  16 
4 9KS7 LYS G 10  ? UNP A0A3B5KEF3 THR 60  conflict                46  17 
4 9KS7 GLN G 19  ? UNP A0A3B5KEF3 LYS 69  conflict                55  18 
4 9KS7 GLN G 20  ? UNP A0A3B5KEF3 ARG 70  conflict                56  19 
4 9KS7 ILE G 117 ? UNP A0A3B5KEF3 VAL 167 conflict                153 20 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_and_software_defined_assembly PISA dimeric 2 
2 author_and_software_defined_assembly PISA dimeric 2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2780  ? 
1 MORE         -63   ? 
1 'SSA (A^2)'  13200 ? 
2 'ABSA (A^2)' 2600  ? 
2 MORE         -62   ? 
2 'SSA (A^2)'  13350 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,C,E,F,G,K,L,M,Q,S 
2 1 B,D,H,I,J,N,O,P,R,T 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 LYS A 10  ? GLN A 20  ? LYS A 46  GLN A 56  1 ? 11 
HELX_P HELX_P2  AA2 THR A 38  ? GLU A 49  ? THR A 74  GLU A 85  1 ? 12 
HELX_P HELX_P3  AA3 SER A 58  ? PHE A 68  ? SER A 94  PHE A 104 1 ? 11 
HELX_P HELX_P4  AA4 ASN A 105 ? ARG A 109 ? ASN A 141 ARG A 145 5 ? 5  
HELX_P HELX_P5  AA5 LEU B 14  ? GLN B 19  ? LEU B 50  GLN B 55  1 ? 6  
HELX_P HELX_P6  AA6 THR B 38  ? GLU B 49  ? THR B 74  GLU B 85  1 ? 12 
HELX_P HELX_P7  AA7 SER B 58  ? PHE B 68  ? SER B 94  PHE B 104 1 ? 11 
HELX_P HELX_P8  AA8 ASN B 105 ? ARG B 109 ? ASN B 141 ARG B 145 5 ? 5  
HELX_P HELX_P9  AA9 PHE C 11  ? LYS C 13  ? PHE E 47  LYS E 49  5 ? 3  
HELX_P HELX_P10 AB1 LEU C 14  ? GLN C 20  ? LEU E 50  GLN E 56  1 ? 7  
HELX_P HELX_P11 AB2 THR C 38  ? GLU C 49  ? THR E 74  GLU E 85  1 ? 12 
HELX_P HELX_P12 AB3 SER C 58  ? ASN C 67  ? SER E 94  ASN E 103 1 ? 10 
HELX_P HELX_P13 AB4 ASN C 105 ? ARG C 109 ? ASN E 141 ARG E 145 5 ? 5  
HELX_P HELX_P14 AB5 PHE D 11  ? LYS D 13  ? PHE G 47  LYS G 49  5 ? 3  
HELX_P HELX_P15 AB6 LEU D 14  ? GLN D 19  ? LEU G 50  GLN G 55  1 ? 6  
HELX_P HELX_P16 AB7 THR D 38  ? GLU D 49  ? THR G 74  GLU G 85  1 ? 12 
HELX_P HELX_P17 AB8 SER D 58  ? ASN D 67  ? SER G 94  ASN G 103 1 ? 10 
HELX_P HELX_P18 AB9 ASN D 105 ? ARG D 109 ? ASN G 141 ARG G 145 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1  disulf ? ? A CYS 46  SG  ? ? ? 1_555 A CYS 138 SG ? ? A CYS 82  A CYS 174 1_555 ? ? ? ? ? ? ? 2.103 ? ? 
disulf2  disulf ? ? A CYS 113 SG  ? ? ? 1_555 A CYS 130 SG ? ? A CYS 149 A CYS 166 1_555 ? ? ? ? ? ? ? 2.061 ? ? 
disulf3  disulf ? ? B CYS 46  SG  ? ? ? 1_555 B CYS 138 SG ? ? B CYS 82  B CYS 174 1_555 ? ? ? ? ? ? ? 2.080 ? ? 
disulf4  disulf ? ? B CYS 113 SG  ? ? ? 1_555 B CYS 130 SG ? ? B CYS 149 B CYS 166 1_555 ? ? ? ? ? ? ? 2.046 ? ? 
disulf5  disulf ? ? C CYS 46  SG  ? ? ? 1_555 C CYS 138 SG ? ? E CYS 82  E CYS 174 1_555 ? ? ? ? ? ? ? 2.087 ? ? 
disulf6  disulf ? ? C CYS 113 SG  ? ? ? 1_555 C CYS 130 SG ? ? E CYS 149 E CYS 166 1_555 ? ? ? ? ? ? ? 2.061 ? ? 
disulf7  disulf ? ? D CYS 46  SG  ? ? ? 1_555 D CYS 138 SG ? ? G CYS 82  G CYS 174 1_555 ? ? ? ? ? ? ? 2.095 ? ? 
disulf8  disulf ? ? D CYS 113 SG  ? ? ? 1_555 D CYS 130 SG ? ? G CYS 149 G CYS 166 1_555 ? ? ? ? ? ? ? 2.052 ? ? 
metalc1  metalc ? ? A ILE 55  O   ? ? ? 1_555 F CA  .   CA ? ? A ILE 91  A CA  202 1_555 ? ? ? ? ? ? ? 2.231 ? ? 
metalc2  metalc ? ? A ASN 57  OD1 ? ? ? 1_555 F CA  .   CA ? ? A ASN 93  A CA  202 1_555 ? ? ? ? ? ? ? 2.333 ? ? 
metalc3  metalc ? ? A GLU 61  OE1 ? ? ? 1_555 F CA  .   CA ? ? A GLU 97  A CA  202 1_555 ? ? ? ? ? ? ? 2.826 ? ? 
metalc4  metalc ? ? A GLU 61  OE2 ? ? ? 1_555 F CA  .   CA ? ? A GLU 97  A CA  202 1_555 ? ? ? ? ? ? ? 2.496 ? ? 
metalc5  metalc ? ? A GLU 102 OE1 ? ? ? 1_555 G CA  .   CA ? ? A GLU 138 A CA  203 1_555 ? ? ? ? ? ? ? 2.516 ? ? 
metalc6  metalc ? ? A ASN 104 OD1 ? ? ? 1_555 G CA  .   CA ? ? A ASN 140 A CA  203 1_555 ? ? ? ? ? ? ? 2.428 ? ? 
metalc7  metalc ? ? A GLU 111 OE1 ? ? ? 1_555 G CA  .   CA ? ? A GLU 147 A CA  203 1_555 ? ? ? ? ? ? ? 2.527 ? ? 
metalc8  metalc ? ? A ASN 126 OD1 ? ? ? 1_555 G CA  .   CA ? ? A ASN 162 A CA  203 1_555 ? ? ? ? ? ? ? 2.355 ? ? 
metalc9  metalc ? ? A ASP 127 O   ? ? ? 1_555 G CA  .   CA ? ? A ASP 163 A CA  203 1_555 ? ? ? ? ? ? ? 2.439 ? ? 
metalc10 metalc ? ? A ASP 127 OD1 ? ? ? 1_555 G CA  .   CA ? ? A ASP 163 A CA  203 1_555 ? ? ? ? ? ? ? 2.375 ? ? 
metalc11 metalc ? ? A GLU 139 OE1 ? ? ? 1_555 F CA  .   CA ? ? A GLU 175 A CA  202 1_555 ? ? ? ? ? ? ? 2.550 ? ? 
metalc12 metalc ? ? A GLU 139 OE2 ? ? ? 1_555 F CA  .   CA ? ? A GLU 175 A CA  202 1_555 ? ? ? ? ? ? ? 2.476 ? ? 
metalc13 metalc ? ? E GOL .   O1  ? ? ? 1_555 G CA  .   CA ? ? A GOL 201 A CA  203 1_555 ? ? ? ? ? ? ? 2.500 ? ? 
metalc14 metalc ? ? E GOL .   O2  ? ? ? 1_555 G CA  .   CA ? ? A GOL 201 A CA  203 1_555 ? ? ? ? ? ? ? 2.473 ? ? 
metalc15 metalc ? ? F CA  .   CA  ? ? ? 1_555 Q HOH .   O  ? ? A CA  202 A HOH 350 1_555 ? ? ? ? ? ? ? 2.371 ? ? 
metalc16 metalc ? ? F CA  .   CA  ? ? ? 1_555 Q HOH .   O  ? ? A CA  202 A HOH 377 1_555 ? ? ? ? ? ? ? 2.450 ? ? 
metalc17 metalc ? ? B ILE 55  O   ? ? ? 1_555 I CA  .   CA ? ? B ILE 91  B CA  202 1_555 ? ? ? ? ? ? ? 2.234 ? ? 
metalc18 metalc ? ? B ASN 57  OD1 ? ? ? 1_555 I CA  .   CA ? ? B ASN 93  B CA  202 1_555 ? ? ? ? ? ? ? 2.316 ? ? 
metalc19 metalc ? ? B GLU 61  OE1 ? ? ? 1_555 I CA  .   CA ? ? B GLU 97  B CA  202 1_555 ? ? ? ? ? ? ? 2.654 ? ? 
metalc20 metalc ? ? B GLU 61  OE2 ? ? ? 1_555 I CA  .   CA ? ? B GLU 97  B CA  202 1_555 ? ? ? ? ? ? ? 2.402 ? ? 
metalc21 metalc ? ? B GLU 102 OE1 ? ? ? 1_555 J CA  .   CA ? ? B GLU 138 B CA  203 1_555 ? ? ? ? ? ? ? 2.535 ? ? 
metalc22 metalc ? ? B ASN 104 OD1 ? ? ? 1_555 J CA  .   CA ? ? B ASN 140 B CA  203 1_555 ? ? ? ? ? ? ? 2.397 ? ? 
metalc23 metalc ? ? B GLU 111 OE1 ? ? ? 1_555 J CA  .   CA ? ? B GLU 147 B CA  203 1_555 ? ? ? ? ? ? ? 2.468 ? ? 
metalc24 metalc ? ? B ASN 126 OD1 ? ? ? 1_555 J CA  .   CA ? ? B ASN 162 B CA  203 1_555 ? ? ? ? ? ? ? 2.447 ? ? 
metalc25 metalc ? ? B ASP 127 O   ? ? ? 1_555 J CA  .   CA ? ? B ASP 163 B CA  203 1_555 ? ? ? ? ? ? ? 2.470 ? ? 
metalc26 metalc ? ? B ASP 127 OD1 ? ? ? 1_555 J CA  .   CA ? ? B ASP 163 B CA  203 1_555 ? ? ? ? ? ? ? 2.390 ? ? 
metalc27 metalc ? ? B GLU 139 OE1 ? ? ? 1_555 I CA  .   CA ? ? B GLU 175 B CA  202 1_555 ? ? ? ? ? ? ? 2.597 ? ? 
metalc28 metalc ? ? B GLU 139 OE2 ? ? ? 1_555 I CA  .   CA ? ? B GLU 175 B CA  202 1_555 ? ? ? ? ? ? ? 2.480 ? ? 
metalc29 metalc ? ? H GOL .   O1  ? ? ? 1_555 J CA  .   CA ? ? B GOL 201 B CA  203 1_555 ? ? ? ? ? ? ? 2.422 ? ? 
metalc30 metalc ? ? H GOL .   O2  ? ? ? 1_555 J CA  .   CA ? ? B GOL 201 B CA  203 1_555 ? ? ? ? ? ? ? 2.499 ? ? 
metalc31 metalc ? ? I CA  .   CA  ? ? ? 1_555 R HOH .   O  ? ? B CA  202 B HOH 359 1_555 ? ? ? ? ? ? ? 2.523 ? ? 
metalc32 metalc ? ? I CA  .   CA  ? ? ? 1_555 R HOH .   O  ? ? B CA  202 B HOH 383 1_555 ? ? ? ? ? ? ? 2.409 ? ? 
metalc33 metalc ? ? C ILE 55  O   ? ? ? 1_555 L CA  .   CA ? ? E ILE 91  E CA  202 1_555 ? ? ? ? ? ? ? 2.300 ? ? 
metalc34 metalc ? ? C ASN 57  OD1 ? ? ? 1_555 L CA  .   CA ? ? E ASN 93  E CA  202 1_555 ? ? ? ? ? ? ? 2.372 ? ? 
metalc35 metalc ? ? C GLU 61  OE1 ? ? ? 1_555 L CA  .   CA ? ? E GLU 97  E CA  202 1_555 ? ? ? ? ? ? ? 2.785 ? ? 
metalc36 metalc ? ? C GLU 61  OE2 ? ? ? 1_555 L CA  .   CA ? ? E GLU 97  E CA  202 1_555 ? ? ? ? ? ? ? 2.467 ? ? 
metalc37 metalc ? ? C GLU 102 OE1 ? ? ? 1_555 M CA  .   CA ? ? E GLU 138 E CA  203 1_555 ? ? ? ? ? ? ? 2.542 ? ? 
metalc38 metalc ? ? C ASN 104 OD1 ? ? ? 1_555 M CA  .   CA ? ? E ASN 140 E CA  203 1_555 ? ? ? ? ? ? ? 2.366 ? ? 
metalc39 metalc ? ? C GLU 111 OE1 ? ? ? 1_555 M CA  .   CA ? ? E GLU 147 E CA  203 1_555 ? ? ? ? ? ? ? 2.533 ? ? 
metalc40 metalc ? ? C ASN 126 OD1 ? ? ? 1_555 M CA  .   CA ? ? E ASN 162 E CA  203 1_555 ? ? ? ? ? ? ? 2.394 ? ? 
metalc41 metalc ? ? C ASP 127 O   ? ? ? 1_555 M CA  .   CA ? ? E ASP 163 E CA  203 1_555 ? ? ? ? ? ? ? 2.456 ? ? 
metalc42 metalc ? ? C ASP 127 OD1 ? ? ? 1_555 M CA  .   CA ? ? E ASP 163 E CA  203 1_555 ? ? ? ? ? ? ? 2.333 ? ? 
metalc43 metalc ? ? C GLU 139 OE1 ? ? ? 1_555 L CA  .   CA ? ? E GLU 175 E CA  202 1_555 ? ? ? ? ? ? ? 2.590 ? ? 
metalc44 metalc ? ? C GLU 139 OE2 ? ? ? 1_555 L CA  .   CA ? ? E GLU 175 E CA  202 1_555 ? ? ? ? ? ? ? 2.415 ? ? 
metalc45 metalc ? ? K GOL .   O1  ? ? ? 1_555 M CA  .   CA ? ? E GOL 201 E CA  203 1_555 ? ? ? ? ? ? ? 2.536 ? ? 
metalc46 metalc ? ? K GOL .   O2  ? ? ? 1_555 M CA  .   CA ? ? E GOL 201 E CA  203 1_555 ? ? ? ? ? ? ? 2.586 ? ? 
metalc47 metalc ? ? L CA  .   CA  ? ? ? 1_555 S HOH .   O  ? ? E CA  202 E HOH 361 1_555 ? ? ? ? ? ? ? 2.441 ? ? 
metalc48 metalc ? ? L CA  .   CA  ? ? ? 1_555 S HOH .   O  ? ? E CA  202 E HOH 379 1_555 ? ? ? ? ? ? ? 2.366 ? ? 
metalc49 metalc ? ? D ILE 55  O   ? ? ? 1_555 O CA  .   CA ? ? G ILE 91  G CA  202 1_555 ? ? ? ? ? ? ? 2.287 ? ? 
metalc50 metalc ? ? D ASN 57  OD1 ? ? ? 1_555 O CA  .   CA ? ? G ASN 93  G CA  202 1_555 ? ? ? ? ? ? ? 2.395 ? ? 
metalc51 metalc ? ? D GLU 61  OE1 ? ? ? 1_555 O CA  .   CA ? ? G GLU 97  G CA  202 1_555 ? ? ? ? ? ? ? 2.757 ? ? 
metalc52 metalc ? ? D GLU 61  OE2 ? ? ? 1_555 O CA  .   CA ? ? G GLU 97  G CA  202 1_555 ? ? ? ? ? ? ? 2.466 ? ? 
metalc53 metalc ? ? D GLU 102 OE1 ? ? ? 1_555 P CA  .   CA ? ? G GLU 138 G CA  203 1_555 ? ? ? ? ? ? ? 2.543 ? ? 
metalc54 metalc ? ? D ASN 104 OD1 ? ? ? 1_555 P CA  .   CA ? ? G ASN 140 G CA  203 1_555 ? ? ? ? ? ? ? 2.382 ? ? 
metalc55 metalc ? ? D GLU 111 OE1 ? ? ? 1_555 P CA  .   CA ? ? G GLU 147 G CA  203 1_555 ? ? ? ? ? ? ? 2.505 ? ? 
metalc56 metalc ? ? D ASN 126 OD1 ? ? ? 1_555 P CA  .   CA ? ? G ASN 162 G CA  203 1_555 ? ? ? ? ? ? ? 2.427 ? ? 
metalc57 metalc ? ? D ASP 127 O   ? ? ? 1_555 P CA  .   CA ? ? G ASP 163 G CA  203 1_555 ? ? ? ? ? ? ? 2.452 ? ? 
metalc58 metalc ? ? D ASP 127 OD1 ? ? ? 1_555 P CA  .   CA ? ? G ASP 163 G CA  203 1_555 ? ? ? ? ? ? ? 2.345 ? ? 
metalc59 metalc ? ? D GLU 139 OE1 ? ? ? 1_555 O CA  .   CA ? ? G GLU 175 G CA  202 1_555 ? ? ? ? ? ? ? 2.503 ? ? 
metalc60 metalc ? ? D GLU 139 OE2 ? ? ? 1_555 O CA  .   CA ? ? G GLU 175 G CA  202 1_555 ? ? ? ? ? ? ? 2.451 ? ? 
metalc61 metalc ? ? N GOL .   O1  ? ? ? 1_555 P CA  .   CA ? ? G GOL 201 G CA  203 1_555 ? ? ? ? ? ? ? 2.519 ? ? 
metalc62 metalc ? ? N GOL .   O2  ? ? ? 1_555 P CA  .   CA ? ? G GOL 201 G CA  203 1_555 ? ? ? ? ? ? ? 2.571 ? ? 
metalc63 metalc ? ? O CA  .   CA  ? ? ? 1_555 T HOH .   O  ? ? G CA  202 G HOH 349 1_555 ? ? ? ? ? ? ? 2.397 ? ? 
metalc64 metalc ? ? O CA  .   CA  ? ? ? 1_555 T HOH .   O  ? ? G CA  202 G HOH 375 1_555 ? ? ? ? ? ? ? 2.466 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1   O   ? A ILE 55  ? A ILE 91  ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 OD1 ? A ASN 57  ? A ASN 93  ? 1_555 80.8  ? 
2   O   ? A ILE 55  ? A ILE 91  ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 OE1 ? A GLU 61  ? A GLU 97  ? 1_555 75.0  ? 
3   OD1 ? A ASN 57  ? A ASN 93  ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 OE1 ? A GLU 61  ? A GLU 97  ? 1_555 81.6  ? 
4   O   ? A ILE 55  ? A ILE 91  ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 OE2 ? A GLU 61  ? A GLU 97  ? 1_555 81.5  ? 
5   OD1 ? A ASN 57  ? A ASN 93  ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 OE2 ? A GLU 61  ? A GLU 97  ? 1_555 130.4 ? 
6   OE1 ? A GLU 61  ? A GLU 97  ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 OE2 ? A GLU 61  ? A GLU 97  ? 1_555 49.1  ? 
7   O   ? A ILE 55  ? A ILE 91  ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 OE1 ? A GLU 139 ? A GLU 175 ? 1_555 77.6  ? 
8   OD1 ? A ASN 57  ? A ASN 93  ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 OE1 ? A GLU 139 ? A GLU 175 ? 1_555 137.7 ? 
9   OE1 ? A GLU 61  ? A GLU 97  ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 OE1 ? A GLU 139 ? A GLU 175 ? 1_555 125.9 ? 
10  OE2 ? A GLU 61  ? A GLU 97  ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 OE1 ? A GLU 139 ? A GLU 175 ? 1_555 81.5  ? 
11  O   ? A ILE 55  ? A ILE 91  ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 OE2 ? A GLU 139 ? A GLU 175 ? 1_555 127.9 ? 
12  OD1 ? A ASN 57  ? A ASN 93  ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 OE2 ? A GLU 139 ? A GLU 175 ? 1_555 144.9 ? 
13  OE1 ? A GLU 61  ? A GLU 97  ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 OE2 ? A GLU 139 ? A GLU 175 ? 1_555 121.8 ? 
14  OE2 ? A GLU 61  ? A GLU 97  ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 OE2 ? A GLU 139 ? A GLU 175 ? 1_555 79.1  ? 
15  OE1 ? A GLU 139 ? A GLU 175 ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 OE2 ? A GLU 139 ? A GLU 175 ? 1_555 52.0  ? 
16  O   ? A ILE 55  ? A ILE 91  ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 O   ? Q HOH .   ? A HOH 350 ? 1_555 107.2 ? 
17  OD1 ? A ASN 57  ? A ASN 93  ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 O   ? Q HOH .   ? A HOH 350 ? 1_555 74.4  ? 
18  OE1 ? A GLU 61  ? A GLU 97  ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 O   ? Q HOH .   ? A HOH 350 ? 1_555 155.1 ? 
19  OE2 ? A GLU 61  ? A GLU 97  ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 O   ? Q HOH .   ? A HOH 350 ? 1_555 155.1 ? 
20  OE1 ? A GLU 139 ? A GLU 175 ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 O   ? Q HOH .   ? A HOH 350 ? 1_555 77.9  ? 
21  OE2 ? A GLU 139 ? A GLU 175 ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 O   ? Q HOH .   ? A HOH 350 ? 1_555 77.2  ? 
22  O   ? A ILE 55  ? A ILE 91  ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 O   ? Q HOH .   ? A HOH 377 ? 1_555 145.7 ? 
23  OD1 ? A ASN 57  ? A ASN 93  ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 O   ? Q HOH .   ? A HOH 377 ? 1_555 80.4  ? 
24  OE1 ? A GLU 61  ? A GLU 97  ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 O   ? Q HOH .   ? A HOH 377 ? 1_555 74.1  ? 
25  OE2 ? A GLU 61  ? A GLU 97  ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 O   ? Q HOH .   ? A HOH 377 ? 1_555 89.3  ? 
26  OE1 ? A GLU 139 ? A GLU 175 ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 O   ? Q HOH .   ? A HOH 377 ? 1_555 133.8 ? 
27  OE2 ? A GLU 139 ? A GLU 175 ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 O   ? Q HOH .   ? A HOH 377 ? 1_555 81.9  ? 
28  O   ? Q HOH .   ? A HOH 350 ? 1_555 CA ? F CA . ? A CA 202 ? 1_555 O   ? Q HOH .   ? A HOH 377 ? 1_555 95.0  ? 
29  OE1 ? A GLU 102 ? A GLU 138 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 OD1 ? A ASN 104 ? A ASN 140 ? 1_555 73.1  ? 
30  OE1 ? A GLU 102 ? A GLU 138 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 OE1 ? A GLU 111 ? A GLU 147 ? 1_555 143.4 ? 
31  OD1 ? A ASN 104 ? A ASN 140 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 OE1 ? A GLU 111 ? A GLU 147 ? 1_555 73.7  ? 
32  OE1 ? A GLU 102 ? A GLU 138 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 OD1 ? A ASN 126 ? A ASN 162 ? 1_555 66.6  ? 
33  OD1 ? A ASN 104 ? A ASN 140 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 OD1 ? A ASN 126 ? A ASN 162 ? 1_555 137.7 ? 
34  OE1 ? A GLU 111 ? A GLU 147 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 OD1 ? A ASN 126 ? A ASN 162 ? 1_555 148.5 ? 
35  OE1 ? A GLU 102 ? A GLU 138 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 O   ? A ASP 127 ? A ASP 163 ? 1_555 128.5 ? 
36  OD1 ? A ASN 104 ? A ASN 140 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 O   ? A ASP 127 ? A ASP 163 ? 1_555 140.5 ? 
37  OE1 ? A GLU 111 ? A GLU 147 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 O   ? A ASP 127 ? A ASP 163 ? 1_555 73.0  ? 
38  OD1 ? A ASN 126 ? A ASN 162 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 O   ? A ASP 127 ? A ASP 163 ? 1_555 78.1  ? 
39  OE1 ? A GLU 102 ? A GLU 138 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 OD1 ? A ASP 127 ? A ASP 163 ? 1_555 73.6  ? 
40  OD1 ? A ASN 104 ? A ASN 140 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 OD1 ? A ASP 127 ? A ASP 163 ? 1_555 84.1  ? 
41  OE1 ? A GLU 111 ? A GLU 147 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 OD1 ? A ASP 127 ? A ASP 163 ? 1_555 88.1  ? 
42  OD1 ? A ASN 126 ? A ASN 162 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 OD1 ? A ASP 127 ? A ASP 163 ? 1_555 96.0  ? 
43  O   ? A ASP 127 ? A ASP 163 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 OD1 ? A ASP 127 ? A ASP 163 ? 1_555 74.2  ? 
44  OE1 ? A GLU 102 ? A GLU 138 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 O1  ? E GOL .   ? A GOL 201 ? 1_555 133.6 ? 
45  OD1 ? A ASN 104 ? A ASN 140 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 O1  ? E GOL .   ? A GOL 201 ? 1_555 119.5 ? 
46  OE1 ? A GLU 111 ? A GLU 147 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 O1  ? E GOL .   ? A GOL 201 ? 1_555 77.3  ? 
47  OD1 ? A ASN 126 ? A ASN 162 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 O1  ? E GOL .   ? A GOL 201 ? 1_555 82.3  ? 
48  O   ? A ASP 127 ? A ASP 163 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 O1  ? E GOL .   ? A GOL 201 ? 1_555 72.5  ? 
49  OD1 ? A ASP 127 ? A ASP 163 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 O1  ? E GOL .   ? A GOL 201 ? 1_555 146.3 ? 
50  OE1 ? A GLU 102 ? A GLU 138 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 O2  ? E GOL .   ? A GOL 201 ? 1_555 74.5  ? 
51  OD1 ? A ASN 104 ? A ASN 140 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 O2  ? E GOL .   ? A GOL 201 ? 1_555 76.7  ? 
52  OE1 ? A GLU 111 ? A GLU 147 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 O2  ? E GOL .   ? A GOL 201 ? 1_555 112.0 ? 
53  OD1 ? A ASN 126 ? A ASN 162 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 O2  ? E GOL .   ? A GOL 201 ? 1_555 80.9  ? 
54  O   ? A ASP 127 ? A ASP 163 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 O2  ? E GOL .   ? A GOL 201 ? 1_555 136.3 ? 
55  OD1 ? A ASP 127 ? A ASP 163 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 O2  ? E GOL .   ? A GOL 201 ? 1_555 146.4 ? 
56  O1  ? E GOL .   ? A GOL 201 ? 1_555 CA ? G CA . ? A CA 203 ? 1_555 O2  ? E GOL .   ? A GOL 201 ? 1_555 66.9  ? 
57  O   ? B ILE 55  ? B ILE 91  ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 OD1 ? B ASN 57  ? B ASN 93  ? 1_555 80.8  ? 
58  O   ? B ILE 55  ? B ILE 91  ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 OE1 ? B GLU 61  ? B GLU 97  ? 1_555 76.4  ? 
59  OD1 ? B ASN 57  ? B ASN 93  ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 OE1 ? B GLU 61  ? B GLU 97  ? 1_555 81.4  ? 
60  O   ? B ILE 55  ? B ILE 91  ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 OE2 ? B GLU 61  ? B GLU 97  ? 1_555 85.1  ? 
61  OD1 ? B ASN 57  ? B ASN 93  ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 OE2 ? B GLU 61  ? B GLU 97  ? 1_555 132.6 ? 
62  OE1 ? B GLU 61  ? B GLU 97  ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 OE2 ? B GLU 61  ? B GLU 97  ? 1_555 51.3  ? 
63  O   ? B ILE 55  ? B ILE 91  ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 OE1 ? B GLU 139 ? B GLU 175 ? 1_555 78.3  ? 
64  OD1 ? B ASN 57  ? B ASN 93  ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 OE1 ? B GLU 139 ? B GLU 175 ? 1_555 136.8 ? 
65  OE1 ? B GLU 61  ? B GLU 97  ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 OE1 ? B GLU 139 ? B GLU 175 ? 1_555 128.5 ? 
66  OE2 ? B GLU 61  ? B GLU 97  ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 OE1 ? B GLU 139 ? B GLU 175 ? 1_555 82.6  ? 
67  O   ? B ILE 55  ? B ILE 91  ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 OE2 ? B GLU 139 ? B GLU 175 ? 1_555 128.1 ? 
68  OD1 ? B ASN 57  ? B ASN 93  ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 OE2 ? B GLU 139 ? B GLU 175 ? 1_555 142.9 ? 
69  OE1 ? B GLU 61  ? B GLU 97  ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 OE2 ? B GLU 139 ? B GLU 175 ? 1_555 123.8 ? 
70  OE2 ? B GLU 61  ? B GLU 97  ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 OE2 ? B GLU 139 ? B GLU 175 ? 1_555 78.5  ? 
71  OE1 ? B GLU 139 ? B GLU 175 ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 OE2 ? B GLU 139 ? B GLU 175 ? 1_555 51.2  ? 
72  O   ? B ILE 55  ? B ILE 91  ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 O   ? R HOH .   ? B HOH 359 ? 1_555 105.6 ? 
73  OD1 ? B ASN 57  ? B ASN 93  ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 O   ? R HOH .   ? B HOH 359 ? 1_555 73.4  ? 
74  OE1 ? B GLU 61  ? B GLU 97  ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 O   ? R HOH .   ? B HOH 359 ? 1_555 153.9 ? 
75  OE2 ? B GLU 61  ? B GLU 97  ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 O   ? R HOH .   ? B HOH 359 ? 1_555 153.8 ? 
76  OE1 ? B GLU 139 ? B GLU 175 ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 O   ? R HOH .   ? B HOH 359 ? 1_555 76.5  ? 
77  OE2 ? B GLU 139 ? B GLU 175 ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 O   ? R HOH .   ? B HOH 359 ? 1_555 76.1  ? 
78  O   ? B ILE 55  ? B ILE 91  ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 O   ? R HOH .   ? B HOH 383 ? 1_555 150.5 ? 
79  OD1 ? B ASN 57  ? B ASN 93  ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 O   ? R HOH .   ? B HOH 383 ? 1_555 82.6  ? 
80  OE1 ? B GLU 61  ? B GLU 97  ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 O   ? R HOH .   ? B HOH 383 ? 1_555 77.0  ? 
81  OE2 ? B GLU 61  ? B GLU 97  ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 O   ? R HOH .   ? B HOH 383 ? 1_555 88.4  ? 
82  OE1 ? B GLU 139 ? B GLU 175 ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 O   ? R HOH .   ? B HOH 383 ? 1_555 129.4 ? 
83  OE2 ? B GLU 139 ? B GLU 175 ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 O   ? R HOH .   ? B HOH 383 ? 1_555 78.2  ? 
84  O   ? R HOH .   ? B HOH 359 ? 1_555 CA ? I CA . ? B CA 202 ? 1_555 O   ? R HOH .   ? B HOH 383 ? 1_555 92.7  ? 
85  OE1 ? B GLU 102 ? B GLU 138 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 OD1 ? B ASN 104 ? B ASN 140 ? 1_555 71.4  ? 
86  OE1 ? B GLU 102 ? B GLU 138 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 OE1 ? B GLU 111 ? B GLU 147 ? 1_555 145.0 ? 
87  OD1 ? B ASN 104 ? B ASN 140 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 OE1 ? B GLU 111 ? B GLU 147 ? 1_555 77.6  ? 
88  OE1 ? B GLU 102 ? B GLU 138 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 OD1 ? B ASN 126 ? B ASN 162 ? 1_555 67.1  ? 
89  OD1 ? B ASN 104 ? B ASN 140 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 OD1 ? B ASN 126 ? B ASN 162 ? 1_555 137.1 ? 
90  OE1 ? B GLU 111 ? B GLU 147 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 OD1 ? B ASN 126 ? B ASN 162 ? 1_555 145.2 ? 
91  OE1 ? B GLU 102 ? B GLU 138 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 O   ? B ASP 127 ? B ASP 163 ? 1_555 127.5 ? 
92  OD1 ? B ASN 104 ? B ASN 140 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 O   ? B ASP 127 ? B ASP 163 ? 1_555 143.0 ? 
93  OE1 ? B GLU 111 ? B GLU 147 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 O   ? B ASP 127 ? B ASP 163 ? 1_555 71.9  ? 
94  OD1 ? B ASN 126 ? B ASN 162 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 O   ? B ASP 127 ? B ASP 163 ? 1_555 75.1  ? 
95  OE1 ? B GLU 102 ? B GLU 138 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 OD1 ? B ASP 127 ? B ASP 163 ? 1_555 72.6  ? 
96  OD1 ? B ASN 104 ? B ASN 140 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 OD1 ? B ASP 127 ? B ASP 163 ? 1_555 83.0  ? 
97  OE1 ? B GLU 111 ? B GLU 147 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 OD1 ? B ASP 127 ? B ASP 163 ? 1_555 88.0  ? 
98  OD1 ? B ASN 126 ? B ASN 162 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 OD1 ? B ASP 127 ? B ASP 163 ? 1_555 94.2  ? 
99  O   ? B ASP 127 ? B ASP 163 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 OD1 ? B ASP 127 ? B ASP 163 ? 1_555 75.5  ? 
100 OE1 ? B GLU 102 ? B GLU 138 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 O1  ? H GOL .   ? B GOL 201 ? 1_555 134.2 ? 
101 OD1 ? B ASN 104 ? B ASN 140 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 O1  ? H GOL .   ? B GOL 201 ? 1_555 123.4 ? 
102 OE1 ? B GLU 111 ? B GLU 147 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 O1  ? H GOL .   ? B GOL 201 ? 1_555 77.2  ? 
103 OD1 ? B ASN 126 ? B ASN 162 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 O1  ? H GOL .   ? B GOL 201 ? 1_555 81.3  ? 
104 O   ? B ASP 127 ? B ASP 163 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 O1  ? H GOL .   ? B GOL 201 ? 1_555 69.6  ? 
105 OD1 ? B ASP 127 ? B ASP 163 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 O1  ? H GOL .   ? B GOL 201 ? 1_555 144.8 ? 
106 OE1 ? B GLU 102 ? B GLU 138 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 O2  ? H GOL .   ? B GOL 201 ? 1_555 76.2  ? 
107 OD1 ? B ASN 104 ? B ASN 140 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 O2  ? H GOL .   ? B GOL 201 ? 1_555 78.0  ? 
108 OE1 ? B GLU 111 ? B GLU 147 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 O2  ? H GOL .   ? B GOL 201 ? 1_555 113.2 ? 
109 OD1 ? B ASN 126 ? B ASN 162 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 O2  ? H GOL .   ? B GOL 201 ? 1_555 82.2  ? 
110 O   ? B ASP 127 ? B ASP 163 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 O2  ? H GOL .   ? B GOL 201 ? 1_555 133.4 ? 
111 OD1 ? B ASP 127 ? B ASP 163 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 O2  ? H GOL .   ? B GOL 201 ? 1_555 147.3 ? 
112 O1  ? H GOL .   ? B GOL 201 ? 1_555 CA ? J CA . ? B CA 203 ? 1_555 O2  ? H GOL .   ? B GOL 201 ? 1_555 67.1  ? 
113 O   ? C ILE 55  ? E ILE 91  ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 OD1 ? C ASN 57  ? E ASN 93  ? 1_555 78.9  ? 
114 O   ? C ILE 55  ? E ILE 91  ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 OE1 ? C GLU 61  ? E GLU 97  ? 1_555 73.5  ? 
115 OD1 ? C ASN 57  ? E ASN 93  ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 OE1 ? C GLU 61  ? E GLU 97  ? 1_555 79.3  ? 
116 O   ? C ILE 55  ? E ILE 91  ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 OE2 ? C GLU 61  ? E GLU 97  ? 1_555 83.3  ? 
117 OD1 ? C ASN 57  ? E ASN 93  ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 OE2 ? C GLU 61  ? E GLU 97  ? 1_555 129.0 ? 
118 OE1 ? C GLU 61  ? E GLU 97  ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 OE2 ? C GLU 61  ? E GLU 97  ? 1_555 49.8  ? 
119 O   ? C ILE 55  ? E ILE 91  ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 OE1 ? C GLU 139 ? E GLU 175 ? 1_555 78.4  ? 
120 OD1 ? C ASN 57  ? E ASN 93  ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 OE1 ? C GLU 139 ? E GLU 175 ? 1_555 137.9 ? 
121 OE1 ? C GLU 61  ? E GLU 97  ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 OE1 ? C GLU 139 ? E GLU 175 ? 1_555 126.3 ? 
122 OE2 ? C GLU 61  ? E GLU 97  ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 OE1 ? C GLU 139 ? E GLU 175 ? 1_555 82.5  ? 
123 O   ? C ILE 55  ? E ILE 91  ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 OE2 ? C GLU 139 ? E GLU 175 ? 1_555 128.7 ? 
124 OD1 ? C ASN 57  ? E ASN 93  ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 OE2 ? C GLU 139 ? E GLU 175 ? 1_555 145.7 ? 
125 OE1 ? C GLU 61  ? E GLU 97  ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 OE2 ? C GLU 139 ? E GLU 175 ? 1_555 124.1 ? 
126 OE2 ? C GLU 61  ? E GLU 97  ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 OE2 ? C GLU 139 ? E GLU 175 ? 1_555 79.6  ? 
127 OE1 ? C GLU 139 ? E GLU 175 ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 OE2 ? C GLU 139 ? E GLU 175 ? 1_555 51.7  ? 
128 O   ? C ILE 55  ? E ILE 91  ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 O   ? S HOH .   ? E HOH 361 ? 1_555 105.2 ? 
129 OD1 ? C ASN 57  ? E ASN 93  ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 O   ? S HOH .   ? E HOH 361 ? 1_555 73.3  ? 
130 OE1 ? C GLU 61  ? E GLU 97  ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 O   ? S HOH .   ? E HOH 361 ? 1_555 152.1 ? 
131 OE2 ? C GLU 61  ? E GLU 97  ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 O   ? S HOH .   ? E HOH 361 ? 1_555 157.7 ? 
132 OE1 ? C GLU 139 ? E GLU 175 ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 O   ? S HOH .   ? E HOH 361 ? 1_555 79.2  ? 
133 OE2 ? C GLU 139 ? E GLU 175 ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 O   ? S HOH .   ? E HOH 361 ? 1_555 79.1  ? 
134 O   ? C ILE 55  ? E ILE 91  ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 O   ? S HOH .   ? E HOH 379 ? 1_555 149.1 ? 
135 OD1 ? C ASN 57  ? E ASN 93  ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 O   ? S HOH .   ? E HOH 379 ? 1_555 82.3  ? 
136 OE1 ? C GLU 61  ? E GLU 97  ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 O   ? S HOH .   ? E HOH 379 ? 1_555 79.0  ? 
137 OE2 ? C GLU 61  ? E GLU 97  ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 O   ? S HOH .   ? E HOH 379 ? 1_555 89.8  ? 
138 OE1 ? C GLU 139 ? E GLU 175 ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 O   ? S HOH .   ? E HOH 379 ? 1_555 130.6 ? 
139 OE2 ? C GLU 139 ? E GLU 175 ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 O   ? S HOH .   ? E HOH 379 ? 1_555 78.9  ? 
140 O   ? S HOH .   ? E HOH 361 ? 1_555 CA ? L CA . ? E CA 202 ? 1_555 O   ? S HOH .   ? E HOH 379 ? 1_555 92.5  ? 
141 OE1 ? C GLU 102 ? E GLU 138 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 OD1 ? C ASN 104 ? E ASN 140 ? 1_555 73.0  ? 
142 OE1 ? C GLU 102 ? E GLU 138 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 OE1 ? C GLU 111 ? E GLU 147 ? 1_555 144.6 ? 
143 OD1 ? C ASN 104 ? E ASN 140 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 OE1 ? C GLU 111 ? E GLU 147 ? 1_555 75.2  ? 
144 OE1 ? C GLU 102 ? E GLU 138 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 OD1 ? C ASN 126 ? E ASN 162 ? 1_555 67.1  ? 
145 OD1 ? C ASN 104 ? E ASN 140 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 OD1 ? C ASN 126 ? E ASN 162 ? 1_555 138.0 ? 
146 OE1 ? C GLU 111 ? E GLU 147 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 OD1 ? C ASN 126 ? E ASN 162 ? 1_555 146.7 ? 
147 OE1 ? C GLU 102 ? E GLU 138 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 O   ? C ASP 127 ? E ASP 163 ? 1_555 129.3 ? 
148 OD1 ? C ASN 104 ? E ASN 140 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 O   ? C ASP 127 ? E ASP 163 ? 1_555 142.7 ? 
149 OE1 ? C GLU 111 ? E GLU 147 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 O   ? C ASP 127 ? E ASP 163 ? 1_555 72.4  ? 
150 OD1 ? C ASN 126 ? E ASN 162 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 O   ? C ASP 127 ? E ASP 163 ? 1_555 76.5  ? 
151 OE1 ? C GLU 102 ? E GLU 138 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 OD1 ? C ASP 127 ? E ASP 163 ? 1_555 74.2  ? 
152 OD1 ? C ASN 104 ? E ASN 140 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 OD1 ? C ASP 127 ? E ASP 163 ? 1_555 85.5  ? 
153 OE1 ? C GLU 111 ? E GLU 147 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 OD1 ? C ASP 127 ? E ASP 163 ? 1_555 88.2  ? 
154 OD1 ? C ASN 126 ? E ASN 162 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 OD1 ? C ASP 127 ? E ASP 163 ? 1_555 95.5  ? 
155 O   ? C ASP 127 ? E ASP 163 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 OD1 ? C ASP 127 ? E ASP 163 ? 1_555 75.6  ? 
156 OE1 ? C GLU 102 ? E GLU 138 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 O1  ? K GOL .   ? E GOL 201 ? 1_555 133.0 ? 
157 OD1 ? C ASN 104 ? E ASN 140 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 O1  ? K GOL .   ? E GOL 201 ? 1_555 120.5 ? 
158 OE1 ? C GLU 111 ? E GLU 147 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 O1  ? K GOL .   ? E GOL 201 ? 1_555 77.5  ? 
159 OD1 ? C ASN 126 ? E ASN 162 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 O1  ? K GOL .   ? E GOL 201 ? 1_555 80.7  ? 
160 O   ? C ASP 127 ? E ASP 163 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 O1  ? K GOL .   ? E GOL 201 ? 1_555 69.5  ? 
161 OD1 ? C ASP 127 ? E ASP 163 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 O1  ? K GOL .   ? E GOL 201 ? 1_555 144.9 ? 
162 OE1 ? C GLU 102 ? E GLU 138 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 O2  ? K GOL .   ? E GOL 201 ? 1_555 75.5  ? 
163 OD1 ? C ASN 104 ? E ASN 140 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 O2  ? K GOL .   ? E GOL 201 ? 1_555 76.6  ? 
164 OE1 ? C GLU 111 ? E GLU 147 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 O2  ? K GOL .   ? E GOL 201 ? 1_555 111.7 ? 
165 OD1 ? C ASN 126 ? E ASN 162 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 O2  ? K GOL .   ? E GOL 201 ? 1_555 81.3  ? 
166 O   ? C ASP 127 ? E ASP 163 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 O2  ? K GOL .   ? E GOL 201 ? 1_555 132.9 ? 
167 OD1 ? C ASP 127 ? E ASP 163 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 O2  ? K GOL .   ? E GOL 201 ? 1_555 148.2 ? 
168 O1  ? K GOL .   ? E GOL 201 ? 1_555 CA ? M CA . ? E CA 203 ? 1_555 O2  ? K GOL .   ? E GOL 201 ? 1_555 66.2  ? 
169 O   ? D ILE 55  ? G ILE 91  ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 OD1 ? D ASN 57  ? G ASN 93  ? 1_555 80.1  ? 
170 O   ? D ILE 55  ? G ILE 91  ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 OE1 ? D GLU 61  ? G GLU 97  ? 1_555 72.7  ? 
171 OD1 ? D ASN 57  ? G ASN 93  ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 OE1 ? D GLU 61  ? G GLU 97  ? 1_555 79.1  ? 
172 O   ? D ILE 55  ? G ILE 91  ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 OE2 ? D GLU 61  ? G GLU 97  ? 1_555 82.5  ? 
173 OD1 ? D ASN 57  ? G ASN 93  ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 OE2 ? D GLU 61  ? G GLU 97  ? 1_555 129.1 ? 
174 OE1 ? D GLU 61  ? G GLU 97  ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 OE2 ? D GLU 61  ? G GLU 97  ? 1_555 50.0  ? 
175 O   ? D ILE 55  ? G ILE 91  ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 OE1 ? D GLU 139 ? G GLU 175 ? 1_555 77.7  ? 
176 OD1 ? D ASN 57  ? G ASN 93  ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 OE1 ? D GLU 139 ? G GLU 175 ? 1_555 138.7 ? 
177 OE1 ? D GLU 61  ? G GLU 97  ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 OE1 ? D GLU 139 ? G GLU 175 ? 1_555 125.4 ? 
178 OE2 ? D GLU 61  ? G GLU 97  ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 OE1 ? D GLU 139 ? G GLU 175 ? 1_555 81.7  ? 
179 O   ? D ILE 55  ? G ILE 91  ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 OE2 ? D GLU 139 ? G GLU 175 ? 1_555 129.5 ? 
180 OD1 ? D ASN 57  ? G ASN 93  ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 OE2 ? D GLU 139 ? G GLU 175 ? 1_555 143.0 ? 
181 OE1 ? D GLU 61  ? G GLU 97  ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 OE2 ? D GLU 139 ? G GLU 175 ? 1_555 126.4 ? 
182 OE2 ? D GLU 61  ? G GLU 97  ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 OE2 ? D GLU 139 ? G GLU 175 ? 1_555 81.9  ? 
183 OE1 ? D GLU 139 ? G GLU 175 ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 OE2 ? D GLU 139 ? G GLU 175 ? 1_555 52.7  ? 
184 O   ? D ILE 55  ? G ILE 91  ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 O   ? T HOH .   ? G HOH 349 ? 1_555 106.3 ? 
185 OD1 ? D ASN 57  ? G ASN 93  ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 O   ? T HOH .   ? G HOH 349 ? 1_555 73.0  ? 
186 OE1 ? D GLU 61  ? G GLU 97  ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 O   ? T HOH .   ? G HOH 349 ? 1_555 151.7 ? 
187 OE2 ? D GLU 61  ? G GLU 97  ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 O   ? T HOH .   ? G HOH 349 ? 1_555 157.8 ? 
188 OE1 ? D GLU 139 ? G GLU 175 ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 O   ? T HOH .   ? G HOH 349 ? 1_555 80.4  ? 
189 OE2 ? D GLU 139 ? G GLU 175 ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 O   ? T HOH .   ? G HOH 349 ? 1_555 76.9  ? 
190 O   ? D ILE 55  ? G ILE 91  ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 O   ? T HOH .   ? G HOH 375 ? 1_555 149.5 ? 
191 OD1 ? D ASN 57  ? G ASN 93  ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 O   ? T HOH .   ? G HOH 375 ? 1_555 81.4  ? 
192 OE1 ? D GLU 61  ? G GLU 97  ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 O   ? T HOH .   ? G HOH 375 ? 1_555 80.1  ? 
193 OE2 ? D GLU 61  ? G GLU 97  ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 O   ? T HOH .   ? G HOH 375 ? 1_555 90.8  ? 
194 OE1 ? D GLU 139 ? G GLU 175 ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 O   ? T HOH .   ? G HOH 375 ? 1_555 130.9 ? 
195 OE2 ? D GLU 139 ? G GLU 175 ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 O   ? T HOH .   ? G HOH 375 ? 1_555 78.2  ? 
196 O   ? T HOH .   ? G HOH 349 ? 1_555 CA ? O CA . ? G CA 202 ? 1_555 O   ? T HOH .   ? G HOH 375 ? 1_555 91.0  ? 
197 OE1 ? D GLU 102 ? G GLU 138 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 OD1 ? D ASN 104 ? G ASN 140 ? 1_555 72.1  ? 
198 OE1 ? D GLU 102 ? G GLU 138 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 OE1 ? D GLU 111 ? G GLU 147 ? 1_555 145.7 ? 
199 OD1 ? D ASN 104 ? G ASN 140 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 OE1 ? D GLU 111 ? G GLU 147 ? 1_555 77.0  ? 
200 OE1 ? D GLU 102 ? G GLU 138 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 OD1 ? D ASN 126 ? G ASN 162 ? 1_555 66.9  ? 
201 OD1 ? D ASN 104 ? G ASN 140 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 OD1 ? D ASN 126 ? G ASN 162 ? 1_555 137.0 ? 
202 OE1 ? D GLU 111 ? G GLU 147 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 OD1 ? D ASN 126 ? G ASN 162 ? 1_555 145.9 ? 
203 OE1 ? D GLU 102 ? G GLU 138 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 O   ? D ASP 127 ? G ASP 163 ? 1_555 130.2 ? 
204 OD1 ? D ASN 104 ? G ASN 140 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 O   ? D ASP 127 ? G ASP 163 ? 1_555 142.2 ? 
205 OE1 ? D GLU 111 ? G GLU 147 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 O   ? D ASP 127 ? G ASP 163 ? 1_555 70.6  ? 
206 OD1 ? D ASN 126 ? G ASN 162 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 O   ? D ASP 127 ? G ASP 163 ? 1_555 77.9  ? 
207 OE1 ? D GLU 102 ? G GLU 138 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 OD1 ? D ASP 127 ? G ASP 163 ? 1_555 73.6  ? 
208 OD1 ? D ASN 104 ? G ASN 140 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 OD1 ? D ASP 127 ? G ASP 163 ? 1_555 86.5  ? 
209 OE1 ? D GLU 111 ? G GLU 147 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 OD1 ? D ASP 127 ? G ASP 163 ? 1_555 90.2  ? 
210 OD1 ? D ASN 126 ? G ASN 162 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 OD1 ? D ASP 127 ? G ASP 163 ? 1_555 94.1  ? 
211 O   ? D ASP 127 ? G ASP 163 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 OD1 ? D ASP 127 ? G ASP 163 ? 1_555 74.9  ? 
212 OE1 ? D GLU 102 ? G GLU 138 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 O1  ? N GOL .   ? G GOL 201 ? 1_555 133.8 ? 
213 OD1 ? D ASN 104 ? G ASN 140 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 O1  ? N GOL .   ? G GOL 201 ? 1_555 121.2 ? 
214 OE1 ? D GLU 111 ? G GLU 147 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 O1  ? N GOL .   ? G GOL 201 ? 1_555 75.7  ? 
215 OD1 ? D ASN 126 ? G ASN 162 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 O1  ? N GOL .   ? G GOL 201 ? 1_555 81.1  ? 
216 O   ? D ASP 127 ? G ASP 163 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 O1  ? N GOL .   ? G GOL 201 ? 1_555 69.0  ? 
217 OD1 ? D ASP 127 ? G ASP 163 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 O1  ? N GOL .   ? G GOL 201 ? 1_555 143.8 ? 
218 OE1 ? D GLU 102 ? G GLU 138 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 O2  ? N GOL .   ? G GOL 201 ? 1_555 76.7  ? 
219 OD1 ? D ASN 104 ? G ASN 140 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 O2  ? N GOL .   ? G GOL 201 ? 1_555 77.9  ? 
220 OE1 ? D GLU 111 ? G GLU 147 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 O2  ? N GOL .   ? G GOL 201 ? 1_555 111.1 ? 
221 OD1 ? D ASN 126 ? G ASN 162 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 O2  ? N GOL .   ? G GOL 201 ? 1_555 80.4  ? 
222 O   ? D ASP 127 ? G ASP 163 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 O2  ? N GOL .   ? G GOL 201 ? 1_555 131.7 ? 
223 OD1 ? D ASP 127 ? G ASP 163 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 O2  ? N GOL .   ? G GOL 201 ? 1_555 149.5 ? 
224 O1  ? N GOL .   ? G GOL 201 ? 1_555 CA ? P CA . ? G CA 203 ? 1_555 O2  ? N GOL .   ? G GOL 201 ? 1_555 65.4  ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 46  ? CYS A 138 ? CYS A 82  ? 1_555 CYS A 174 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 113 ? CYS A 130 ? CYS A 149 ? 1_555 CYS A 166 ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS B 46  ? CYS B 138 ? CYS B 82  ? 1_555 CYS B 174 ? 1_555 SG SG . . . None 'Disulfide bridge' 
4 CYS B 113 ? CYS B 130 ? CYS B 149 ? 1_555 CYS B 166 ? 1_555 SG SG . . . None 'Disulfide bridge' 
5 CYS C 46  ? CYS C 138 ? CYS E 82  ? 1_555 CYS E 174 ? 1_555 SG SG . . . None 'Disulfide bridge' 
6 CYS C 113 ? CYS C 130 ? CYS E 149 ? 1_555 CYS E 166 ? 1_555 SG SG . . . None 'Disulfide bridge' 
7 CYS D 46  ? CYS D 138 ? CYS G 82  ? 1_555 CYS G 174 ? 1_555 SG SG . . . None 'Disulfide bridge' 
8 CYS D 113 ? CYS D 130 ? CYS G 149 ? 1_555 CYS G 166 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 GLU 102 A . ? GLU 138 A PRO 103 A ? PRO 139 A 1 -2.64 
2 GLU 102 B . ? GLU 138 B PRO 103 B ? PRO 139 B 1 -1.31 
3 GLU 102 C . ? GLU 138 E PRO 103 C ? PRO 139 E 1 -2.89 
4 GLU 102 D . ? GLU 138 G PRO 103 D ? PRO 139 G 1 -3.45 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 5 ? 
AA3 ? 5 ? 
AA4 ? 5 ? 
AA5 ? 5 ? 
AA6 ? 5 ? 
AA7 ? 5 ? 
AA8 ? 5 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? parallel      
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? parallel      
AA3 4 5 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? parallel      
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? parallel      
AA5 4 5 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? parallel      
AA6 3 4 ? anti-parallel 
AA6 4 5 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA7 3 4 ? parallel      
AA7 4 5 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? parallel      
AA8 3 4 ? anti-parallel 
AA8 4 5 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 23  ? PHE A 25  ? PHE A 59  PHE A 61  
AA1 2 SER A 28  ? ILE A 32  ? SER A 64  ILE A 68  
AA1 3 PHE A 135 ? ARG A 141 ? PHE A 171 ARG A 177 
AA1 4 LEU A 72  ? GLU A 78  ? LEU A 108 GLU A 114 
AA1 5 TRP A 85  ? TRP A 87  ? TRP A 121 TRP A 123 
AA2 1 ASP A 52  ? LEU A 53  ? ASP A 88  LEU A 89  
AA2 2 PHE A 135 ? ARG A 141 ? PHE A 171 ARG A 177 
AA2 3 LEU A 72  ? GLU A 78  ? LEU A 108 GLU A 114 
AA2 4 CYS A 113 ? ARG A 119 ? CYS A 149 ARG A 155 
AA2 5 LYS A 122 ? LEU A 128 ? LYS A 158 LEU A 164 
AA3 1 PHE B 23  ? PHE B 25  ? PHE B 59  PHE B 61  
AA3 2 SER B 28  ? ILE B 32  ? SER B 64  ILE B 68  
AA3 3 PHE B 135 ? ARG B 141 ? PHE B 171 ARG B 177 
AA3 4 LEU B 72  ? GLU B 78  ? LEU B 108 GLU B 114 
AA3 5 TRP B 85  ? TRP B 87  ? TRP B 121 TRP B 123 
AA4 1 ASP B 52  ? LEU B 53  ? ASP B 88  LEU B 89  
AA4 2 PHE B 135 ? ARG B 141 ? PHE B 171 ARG B 177 
AA4 3 LEU B 72  ? GLU B 78  ? LEU B 108 GLU B 114 
AA4 4 CYS B 113 ? ASP B 118 ? CYS B 149 ASP B 154 
AA4 5 LYS B 123 ? LEU B 128 ? LYS B 159 LEU B 164 
AA5 1 PHE C 23  ? PHE C 25  ? PHE E 59  PHE E 61  
AA5 2 SER C 28  ? ILE C 32  ? SER E 64  ILE E 68  
AA5 3 PHE C 135 ? ARG C 141 ? PHE E 171 ARG E 177 
AA5 4 LEU C 72  ? GLU C 78  ? LEU E 108 GLU E 114 
AA5 5 TRP C 85  ? TRP C 87  ? TRP E 121 TRP E 123 
AA6 1 ASP C 52  ? LEU C 53  ? ASP E 88  LEU E 89  
AA6 2 PHE C 135 ? ARG C 141 ? PHE E 171 ARG E 177 
AA6 3 LEU C 72  ? GLU C 78  ? LEU E 108 GLU E 114 
AA6 4 CYS C 113 ? ARG C 119 ? CYS E 149 ARG E 155 
AA6 5 LYS C 122 ? LEU C 128 ? LYS E 158 LEU E 164 
AA7 1 PHE D 23  ? PHE D 25  ? PHE G 59  PHE G 61  
AA7 2 SER D 28  ? ILE D 32  ? SER G 64  ILE G 68  
AA7 3 PHE D 135 ? ARG D 141 ? PHE G 171 ARG G 177 
AA7 4 LEU D 72  ? GLU D 78  ? LEU G 108 GLU G 114 
AA7 5 TRP D 85  ? TRP D 87  ? TRP G 121 TRP G 123 
AA8 1 ASP D 52  ? LEU D 53  ? ASP G 88  LEU G 89  
AA8 2 PHE D 135 ? ARG D 141 ? PHE G 171 ARG G 177 
AA8 3 LEU D 72  ? GLU D 78  ? LEU G 108 GLU G 114 
AA8 4 CYS D 113 ? ASP D 118 ? CYS G 149 ASP G 154 
AA8 5 LYS D 123 ? LEU D 128 ? LYS G 159 LEU G 164 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N PHE A 23  ? N PHE A 59  O TYR A 30  ? O TYR A 66  
AA1 2 3 N LEU A 29  ? N LEU A 65  O LYS A 140 ? O LYS A 176 
AA1 3 4 O PHE A 135 ? O PHE A 171 N TRP A 73  ? N TRP A 109 
AA1 4 5 N MET A 77  ? N MET A 113 O ARG A 86  ? O ARG A 122 
AA2 1 2 N ASP A 52  ? N ASP A 88  O GLU A 139 ? O GLU A 175 
AA2 2 3 O PHE A 135 ? O PHE A 171 N TRP A 73  ? N TRP A 109 
AA2 3 4 N LEU A 72  ? N LEU A 108 O GLN A 116 ? O GLN A 152 
AA2 4 5 N ILE A 117 ? N ILE A 153 O GLY A 124 ? O GLY A 160 
AA3 1 2 N PHE B 23  ? N PHE B 59  O TYR B 30  ? O TYR B 66  
AA3 2 3 N LEU B 29  ? N LEU B 65  O LYS B 140 ? O LYS B 176 
AA3 3 4 O PHE B 135 ? O PHE B 171 N TRP B 73  ? N TRP B 109 
AA3 4 5 N MET B 77  ? N MET B 113 O ARG B 86  ? O ARG B 122 
AA4 1 2 N ASP B 52  ? N ASP B 88  O GLU B 139 ? O GLU B 175 
AA4 2 3 O PHE B 135 ? O PHE B 171 N TRP B 73  ? N TRP B 109 
AA4 3 4 N LEU B 72  ? N LEU B 108 O GLN B 116 ? O GLN B 152 
AA4 4 5 N ILE B 117 ? N ILE B 153 O GLY B 124 ? O GLY B 160 
AA5 1 2 N PHE C 23  ? N PHE E 59  O TYR C 30  ? O TYR E 66  
AA5 2 3 N LEU C 29  ? N LEU E 65  O LYS C 140 ? O LYS E 176 
AA5 3 4 O PHE C 135 ? O PHE E 171 N TRP C 73  ? N TRP E 109 
AA5 4 5 N MET C 77  ? N MET E 113 O ARG C 86  ? O ARG E 122 
AA6 1 2 N ASP C 52  ? N ASP E 88  O GLU C 139 ? O GLU E 175 
AA6 2 3 O PHE C 135 ? O PHE E 171 N TRP C 73  ? N TRP E 109 
AA6 3 4 N LEU C 72  ? N LEU E 108 O GLN C 116 ? O GLN E 152 
AA6 4 5 N ILE C 117 ? N ILE E 153 O GLY C 124 ? O GLY E 160 
AA7 1 2 N PHE D 23  ? N PHE G 59  O TYR D 30  ? O TYR G 66  
AA7 2 3 N LEU D 29  ? N LEU G 65  O LYS D 140 ? O LYS G 176 
AA7 3 4 O PHE D 135 ? O PHE G 171 N TRP D 73  ? N TRP G 109 
AA7 4 5 N MET D 77  ? N MET G 113 O ARG D 86  ? O ARG G 122 
AA8 1 2 N ASP D 52  ? N ASP G 88  O GLU D 139 ? O GLU G 175 
AA8 2 3 O PHE D 135 ? O PHE G 171 N TRP D 73  ? N TRP G 109 
AA8 3 4 N LEU D 72  ? N LEU G 108 O GLN D 116 ? O GLN G 152 
AA8 4 5 N CYS D 113 ? N CYS G 149 O LEU D 128 ? O LEU G 164 
# 
_pdbx_entry_details.entry_id                   9KS7 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O   B HOH 301 ? ? O B HOH 322 ? ? 2.13 
2 1 O   E HOH 373 ? ? O E HOH 405 ? ? 2.15 
3 1 O   E HOH 362 ? ? O E HOH 384 ? ? 2.16 
4 1 OE1 G GLU 167 ? ? O G HOH 301 ? ? 2.17 
5 1 O   E HOH 367 ? ? O E HOH 402 ? ? 2.19 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 GLN A 62  ? ? 57.58   -116.75 
2  1 ALA A 87  ? ? -148.44 -154.66 
3  1 ARG A 116 ? ? 51.20   -125.90 
4  1 THR A 130 ? ? -118.70 -94.28  
5  1 ALA B 87  ? ? -127.21 -155.57 
6  1 ARG B 116 ? ? 53.80   -127.48 
7  1 THR B 130 ? ? -117.97 -91.86  
8  1 ASN B 140 ? ? -140.17 -2.19   
9  1 ASP B 157 ? ? 90.68   -25.05  
10 1 ALA E 87  ? ? -130.05 -159.30 
11 1 ARG E 116 ? ? 50.18   -126.34 
12 1 THR E 130 ? ? -114.88 -88.72  
13 1 ASN E 140 ? ? -143.34 -3.51   
14 1 ASP E 157 ? ? 81.73   -7.49   
15 1 GLN G 62  ? ? 60.06   -119.78 
16 1 ALA G 87  ? ? -129.61 -157.88 
17 1 ARG G 116 ? ? 52.89   -128.22 
18 1 THR G 130 ? ? -116.81 -92.64  
19 1 ASN G 140 ? ? -142.46 -4.12   
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z       
2 -x,y+1/2,-z 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 37 ? A MET 1  
2  1 Y 1 A ASN 38 ? A ASN 2  
3  1 Y 1 A GLY 39 ? A GLY 3  
4  1 Y 1 A THR 40 ? A THR 4  
5  1 Y 1 A ALA 41 ? A ALA 5  
6  1 Y 1 A GLU 42 ? A GLU 6  
7  1 Y 1 A GLU 43 ? A GLU 7  
8  1 Y 1 A ARG 44 ? A ARG 8  
9  1 Y 1 B MET 37 ? B MET 1  
10 1 Y 1 B ASN 38 ? B ASN 2  
11 1 Y 1 B GLY 39 ? B GLY 3  
12 1 Y 1 B THR 40 ? B THR 4  
13 1 Y 1 B ALA 41 ? B ALA 5  
14 1 Y 1 B GLU 42 ? B GLU 6  
15 1 Y 1 B GLU 43 ? B GLU 7  
16 1 Y 1 B ARG 44 ? B ARG 8  
17 1 Y 1 B ASN 45 ? B ASN 9  
18 1 Y 1 B LYS 46 ? B LYS 10 
19 1 Y 1 E MET 37 ? C MET 1  
20 1 Y 1 E ASN 38 ? C ASN 2  
21 1 Y 1 E GLY 39 ? C GLY 3  
22 1 Y 1 E THR 40 ? C THR 4  
23 1 Y 1 E ALA 41 ? C ALA 5  
24 1 Y 1 E GLU 42 ? C GLU 6  
25 1 Y 1 E GLU 43 ? C GLU 7  
26 1 Y 1 E ARG 44 ? C ARG 8  
27 1 Y 1 E ASN 45 ? C ASN 9  
28 1 Y 1 E LYS 46 ? C LYS 10 
29 1 Y 1 G MET 37 ? D MET 1  
30 1 Y 1 G ASN 38 ? D ASN 2  
31 1 Y 1 G GLY 39 ? D GLY 3  
32 1 Y 1 G THR 40 ? D THR 4  
33 1 Y 1 G ALA 41 ? D ALA 5  
34 1 Y 1 G GLU 42 ? D GLU 6  
35 1 Y 1 G GLU 43 ? D GLU 7  
36 1 Y 1 G ARG 44 ? D ARG 8  
37 1 Y 1 G ASN 45 ? D ASN 9  
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CA  CA   CA N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
GLN N    N  N N 89  
GLN CA   C  N S 90  
GLN C    C  N N 91  
GLN O    O  N N 92  
GLN CB   C  N N 93  
GLN CG   C  N N 94  
GLN CD   C  N N 95  
GLN OE1  O  N N 96  
GLN NE2  N  N N 97  
GLN OXT  O  N N 98  
GLN H    H  N N 99  
GLN H2   H  N N 100 
GLN HA   H  N N 101 
GLN HB2  H  N N 102 
GLN HB3  H  N N 103 
GLN HG2  H  N N 104 
GLN HG3  H  N N 105 
GLN HE21 H  N N 106 
GLN HE22 H  N N 107 
GLN HXT  H  N N 108 
GLU N    N  N N 109 
GLU CA   C  N S 110 
GLU C    C  N N 111 
GLU O    O  N N 112 
GLU CB   C  N N 113 
GLU CG   C  N N 114 
GLU CD   C  N N 115 
GLU OE1  O  N N 116 
GLU OE2  O  N N 117 
GLU OXT  O  N N 118 
GLU H    H  N N 119 
GLU H2   H  N N 120 
GLU HA   H  N N 121 
GLU HB2  H  N N 122 
GLU HB3  H  N N 123 
GLU HG2  H  N N 124 
GLU HG3  H  N N 125 
GLU HE2  H  N N 126 
GLU HXT  H  N N 127 
GLY N    N  N N 128 
GLY CA   C  N N 129 
GLY C    C  N N 130 
GLY O    O  N N 131 
GLY OXT  O  N N 132 
GLY H    H  N N 133 
GLY H2   H  N N 134 
GLY HA2  H  N N 135 
GLY HA3  H  N N 136 
GLY HXT  H  N N 137 
GOL C1   C  N N 138 
GOL O1   O  N N 139 
GOL C2   C  N N 140 
GOL O2   O  N N 141 
GOL C3   C  N N 142 
GOL O3   O  N N 143 
GOL H11  H  N N 144 
GOL H12  H  N N 145 
GOL HO1  H  N N 146 
GOL H2   H  N N 147 
GOL HO2  H  N N 148 
GOL H31  H  N N 149 
GOL H32  H  N N 150 
GOL HO3  H  N N 151 
HIS N    N  N N 152 
HIS CA   C  N S 153 
HIS C    C  N N 154 
HIS O    O  N N 155 
HIS CB   C  N N 156 
HIS CG   C  Y N 157 
HIS ND1  N  Y N 158 
HIS CD2  C  Y N 159 
HIS CE1  C  Y N 160 
HIS NE2  N  Y N 161 
HIS OXT  O  N N 162 
HIS H    H  N N 163 
HIS H2   H  N N 164 
HIS HA   H  N N 165 
HIS HB2  H  N N 166 
HIS HB3  H  N N 167 
HIS HD1  H  N N 168 
HIS HD2  H  N N 169 
HIS HE1  H  N N 170 
HIS HE2  H  N N 171 
HIS HXT  H  N N 172 
HOH O    O  N N 173 
HOH H1   H  N N 174 
HOH H2   H  N N 175 
ILE N    N  N N 176 
ILE CA   C  N S 177 
ILE C    C  N N 178 
ILE O    O  N N 179 
ILE CB   C  N S 180 
ILE CG1  C  N N 181 
ILE CG2  C  N N 182 
ILE CD1  C  N N 183 
ILE OXT  O  N N 184 
ILE H    H  N N 185 
ILE H2   H  N N 186 
ILE HA   H  N N 187 
ILE HB   H  N N 188 
ILE HG12 H  N N 189 
ILE HG13 H  N N 190 
ILE HG21 H  N N 191 
ILE HG22 H  N N 192 
ILE HG23 H  N N 193 
ILE HD11 H  N N 194 
ILE HD12 H  N N 195 
ILE HD13 H  N N 196 
ILE HXT  H  N N 197 
LEU N    N  N N 198 
LEU CA   C  N S 199 
LEU C    C  N N 200 
LEU O    O  N N 201 
LEU CB   C  N N 202 
LEU CG   C  N N 203 
LEU CD1  C  N N 204 
LEU CD2  C  N N 205 
LEU OXT  O  N N 206 
LEU H    H  N N 207 
LEU H2   H  N N 208 
LEU HA   H  N N 209 
LEU HB2  H  N N 210 
LEU HB3  H  N N 211 
LEU HG   H  N N 212 
LEU HD11 H  N N 213 
LEU HD12 H  N N 214 
LEU HD13 H  N N 215 
LEU HD21 H  N N 216 
LEU HD22 H  N N 217 
LEU HD23 H  N N 218 
LEU HXT  H  N N 219 
LYS N    N  N N 220 
LYS CA   C  N S 221 
LYS C    C  N N 222 
LYS O    O  N N 223 
LYS CB   C  N N 224 
LYS CG   C  N N 225 
LYS CD   C  N N 226 
LYS CE   C  N N 227 
LYS NZ   N  N N 228 
LYS OXT  O  N N 229 
LYS H    H  N N 230 
LYS H2   H  N N 231 
LYS HA   H  N N 232 
LYS HB2  H  N N 233 
LYS HB3  H  N N 234 
LYS HG2  H  N N 235 
LYS HG3  H  N N 236 
LYS HD2  H  N N 237 
LYS HD3  H  N N 238 
LYS HE2  H  N N 239 
LYS HE3  H  N N 240 
LYS HZ1  H  N N 241 
LYS HZ2  H  N N 242 
LYS HZ3  H  N N 243 
LYS HXT  H  N N 244 
MET N    N  N N 245 
MET CA   C  N S 246 
MET C    C  N N 247 
MET O    O  N N 248 
MET CB   C  N N 249 
MET CG   C  N N 250 
MET SD   S  N N 251 
MET CE   C  N N 252 
MET OXT  O  N N 253 
MET H    H  N N 254 
MET H2   H  N N 255 
MET HA   H  N N 256 
MET HB2  H  N N 257 
MET HB3  H  N N 258 
MET HG2  H  N N 259 
MET HG3  H  N N 260 
MET HE1  H  N N 261 
MET HE2  H  N N 262 
MET HE3  H  N N 263 
MET HXT  H  N N 264 
PHE N    N  N N 265 
PHE CA   C  N S 266 
PHE C    C  N N 267 
PHE O    O  N N 268 
PHE CB   C  N N 269 
PHE CG   C  Y N 270 
PHE CD1  C  Y N 271 
PHE CD2  C  Y N 272 
PHE CE1  C  Y N 273 
PHE CE2  C  Y N 274 
PHE CZ   C  Y N 275 
PHE OXT  O  N N 276 
PHE H    H  N N 277 
PHE H2   H  N N 278 
PHE HA   H  N N 279 
PHE HB2  H  N N 280 
PHE HB3  H  N N 281 
PHE HD1  H  N N 282 
PHE HD2  H  N N 283 
PHE HE1  H  N N 284 
PHE HE2  H  N N 285 
PHE HZ   H  N N 286 
PHE HXT  H  N N 287 
PRO N    N  N N 288 
PRO CA   C  N S 289 
PRO C    C  N N 290 
PRO O    O  N N 291 
PRO CB   C  N N 292 
PRO CG   C  N N 293 
PRO CD   C  N N 294 
PRO OXT  O  N N 295 
PRO H    H  N N 296 
PRO HA   H  N N 297 
PRO HB2  H  N N 298 
PRO HB3  H  N N 299 
PRO HG2  H  N N 300 
PRO HG3  H  N N 301 
PRO HD2  H  N N 302 
PRO HD3  H  N N 303 
PRO HXT  H  N N 304 
SER N    N  N N 305 
SER CA   C  N S 306 
SER C    C  N N 307 
SER O    O  N N 308 
SER CB   C  N N 309 
SER OG   O  N N 310 
SER OXT  O  N N 311 
SER H    H  N N 312 
SER H2   H  N N 313 
SER HA   H  N N 314 
SER HB2  H  N N 315 
SER HB3  H  N N 316 
SER HG   H  N N 317 
SER HXT  H  N N 318 
THR N    N  N N 319 
THR CA   C  N S 320 
THR C    C  N N 321 
THR O    O  N N 322 
THR CB   C  N R 323 
THR OG1  O  N N 324 
THR CG2  C  N N 325 
THR OXT  O  N N 326 
THR H    H  N N 327 
THR H2   H  N N 328 
THR HA   H  N N 329 
THR HB   H  N N 330 
THR HG1  H  N N 331 
THR HG21 H  N N 332 
THR HG22 H  N N 333 
THR HG23 H  N N 334 
THR HXT  H  N N 335 
TRP N    N  N N 336 
TRP CA   C  N S 337 
TRP C    C  N N 338 
TRP O    O  N N 339 
TRP CB   C  N N 340 
TRP CG   C  Y N 341 
TRP CD1  C  Y N 342 
TRP CD2  C  Y N 343 
TRP NE1  N  Y N 344 
TRP CE2  C  Y N 345 
TRP CE3  C  Y N 346 
TRP CZ2  C  Y N 347 
TRP CZ3  C  Y N 348 
TRP CH2  C  Y N 349 
TRP OXT  O  N N 350 
TRP H    H  N N 351 
TRP H2   H  N N 352 
TRP HA   H  N N 353 
TRP HB2  H  N N 354 
TRP HB3  H  N N 355 
TRP HD1  H  N N 356 
TRP HE1  H  N N 357 
TRP HE3  H  N N 358 
TRP HZ2  H  N N 359 
TRP HZ3  H  N N 360 
TRP HH2  H  N N 361 
TRP HXT  H  N N 362 
TYR N    N  N N 363 
TYR CA   C  N S 364 
TYR C    C  N N 365 
TYR O    O  N N 366 
TYR CB   C  N N 367 
TYR CG   C  Y N 368 
TYR CD1  C  Y N 369 
TYR CD2  C  Y N 370 
TYR CE1  C  Y N 371 
TYR CE2  C  Y N 372 
TYR CZ   C  Y N 373 
TYR OH   O  N N 374 
TYR OXT  O  N N 375 
TYR H    H  N N 376 
TYR H2   H  N N 377 
TYR HA   H  N N 378 
TYR HB2  H  N N 379 
TYR HB3  H  N N 380 
TYR HD1  H  N N 381 
TYR HD2  H  N N 382 
TYR HE1  H  N N 383 
TYR HE2  H  N N 384 
TYR HH   H  N N 385 
TYR HXT  H  N N 386 
VAL N    N  N N 387 
VAL CA   C  N S 388 
VAL C    C  N N 389 
VAL O    O  N N 390 
VAL CB   C  N N 391 
VAL CG1  C  N N 392 
VAL CG2  C  N N 393 
VAL OXT  O  N N 394 
VAL H    H  N N 395 
VAL H2   H  N N 396 
VAL HA   H  N N 397 
VAL HB   H  N N 398 
VAL HG11 H  N N 399 
VAL HG12 H  N N 400 
VAL HG13 H  N N 401 
VAL HG21 H  N N 402 
VAL HG22 H  N N 403 
VAL HG23 H  N N 404 
VAL HXT  H  N N 405 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
GOL C1  O1   sing N N 129 
GOL C1  C2   sing N N 130 
GOL C1  H11  sing N N 131 
GOL C1  H12  sing N N 132 
GOL O1  HO1  sing N N 133 
GOL C2  O2   sing N N 134 
GOL C2  C3   sing N N 135 
GOL C2  H2   sing N N 136 
GOL O2  HO2  sing N N 137 
GOL C3  O3   sing N N 138 
GOL C3  H31  sing N N 139 
GOL C3  H32  sing N N 140 
GOL O3  HO3  sing N N 141 
HIS N   CA   sing N N 142 
HIS N   H    sing N N 143 
HIS N   H2   sing N N 144 
HIS CA  C    sing N N 145 
HIS CA  CB   sing N N 146 
HIS CA  HA   sing N N 147 
HIS C   O    doub N N 148 
HIS C   OXT  sing N N 149 
HIS CB  CG   sing N N 150 
HIS CB  HB2  sing N N 151 
HIS CB  HB3  sing N N 152 
HIS CG  ND1  sing Y N 153 
HIS CG  CD2  doub Y N 154 
HIS ND1 CE1  doub Y N 155 
HIS ND1 HD1  sing N N 156 
HIS CD2 NE2  sing Y N 157 
HIS CD2 HD2  sing N N 158 
HIS CE1 NE2  sing Y N 159 
HIS CE1 HE1  sing N N 160 
HIS NE2 HE2  sing N N 161 
HIS OXT HXT  sing N N 162 
HOH O   H1   sing N N 163 
HOH O   H2   sing N N 164 
ILE N   CA   sing N N 165 
ILE N   H    sing N N 166 
ILE N   H2   sing N N 167 
ILE CA  C    sing N N 168 
ILE CA  CB   sing N N 169 
ILE CA  HA   sing N N 170 
ILE C   O    doub N N 171 
ILE C   OXT  sing N N 172 
ILE CB  CG1  sing N N 173 
ILE CB  CG2  sing N N 174 
ILE CB  HB   sing N N 175 
ILE CG1 CD1  sing N N 176 
ILE CG1 HG12 sing N N 177 
ILE CG1 HG13 sing N N 178 
ILE CG2 HG21 sing N N 179 
ILE CG2 HG22 sing N N 180 
ILE CG2 HG23 sing N N 181 
ILE CD1 HD11 sing N N 182 
ILE CD1 HD12 sing N N 183 
ILE CD1 HD13 sing N N 184 
ILE OXT HXT  sing N N 185 
LEU N   CA   sing N N 186 
LEU N   H    sing N N 187 
LEU N   H2   sing N N 188 
LEU CA  C    sing N N 189 
LEU CA  CB   sing N N 190 
LEU CA  HA   sing N N 191 
LEU C   O    doub N N 192 
LEU C   OXT  sing N N 193 
LEU CB  CG   sing N N 194 
LEU CB  HB2  sing N N 195 
LEU CB  HB3  sing N N 196 
LEU CG  CD1  sing N N 197 
LEU CG  CD2  sing N N 198 
LEU CG  HG   sing N N 199 
LEU CD1 HD11 sing N N 200 
LEU CD1 HD12 sing N N 201 
LEU CD1 HD13 sing N N 202 
LEU CD2 HD21 sing N N 203 
LEU CD2 HD22 sing N N 204 
LEU CD2 HD23 sing N N 205 
LEU OXT HXT  sing N N 206 
LYS N   CA   sing N N 207 
LYS N   H    sing N N 208 
LYS N   H2   sing N N 209 
LYS CA  C    sing N N 210 
LYS CA  CB   sing N N 211 
LYS CA  HA   sing N N 212 
LYS C   O    doub N N 213 
LYS C   OXT  sing N N 214 
LYS CB  CG   sing N N 215 
LYS CB  HB2  sing N N 216 
LYS CB  HB3  sing N N 217 
LYS CG  CD   sing N N 218 
LYS CG  HG2  sing N N 219 
LYS CG  HG3  sing N N 220 
LYS CD  CE   sing N N 221 
LYS CD  HD2  sing N N 222 
LYS CD  HD3  sing N N 223 
LYS CE  NZ   sing N N 224 
LYS CE  HE2  sing N N 225 
LYS CE  HE3  sing N N 226 
LYS NZ  HZ1  sing N N 227 
LYS NZ  HZ2  sing N N 228 
LYS NZ  HZ3  sing N N 229 
LYS OXT HXT  sing N N 230 
MET N   CA   sing N N 231 
MET N   H    sing N N 232 
MET N   H2   sing N N 233 
MET CA  C    sing N N 234 
MET CA  CB   sing N N 235 
MET CA  HA   sing N N 236 
MET C   O    doub N N 237 
MET C   OXT  sing N N 238 
MET CB  CG   sing N N 239 
MET CB  HB2  sing N N 240 
MET CB  HB3  sing N N 241 
MET CG  SD   sing N N 242 
MET CG  HG2  sing N N 243 
MET CG  HG3  sing N N 244 
MET SD  CE   sing N N 245 
MET CE  HE1  sing N N 246 
MET CE  HE2  sing N N 247 
MET CE  HE3  sing N N 248 
MET OXT HXT  sing N N 249 
PHE N   CA   sing N N 250 
PHE N   H    sing N N 251 
PHE N   H2   sing N N 252 
PHE CA  C    sing N N 253 
PHE CA  CB   sing N N 254 
PHE CA  HA   sing N N 255 
PHE C   O    doub N N 256 
PHE C   OXT  sing N N 257 
PHE CB  CG   sing N N 258 
PHE CB  HB2  sing N N 259 
PHE CB  HB3  sing N N 260 
PHE CG  CD1  doub Y N 261 
PHE CG  CD2  sing Y N 262 
PHE CD1 CE1  sing Y N 263 
PHE CD1 HD1  sing N N 264 
PHE CD2 CE2  doub Y N 265 
PHE CD2 HD2  sing N N 266 
PHE CE1 CZ   doub Y N 267 
PHE CE1 HE1  sing N N 268 
PHE CE2 CZ   sing Y N 269 
PHE CE2 HE2  sing N N 270 
PHE CZ  HZ   sing N N 271 
PHE OXT HXT  sing N N 272 
PRO N   CA   sing N N 273 
PRO N   CD   sing N N 274 
PRO N   H    sing N N 275 
PRO CA  C    sing N N 276 
PRO CA  CB   sing N N 277 
PRO CA  HA   sing N N 278 
PRO C   O    doub N N 279 
PRO C   OXT  sing N N 280 
PRO CB  CG   sing N N 281 
PRO CB  HB2  sing N N 282 
PRO CB  HB3  sing N N 283 
PRO CG  CD   sing N N 284 
PRO CG  HG2  sing N N 285 
PRO CG  HG3  sing N N 286 
PRO CD  HD2  sing N N 287 
PRO CD  HD3  sing N N 288 
PRO OXT HXT  sing N N 289 
SER N   CA   sing N N 290 
SER N   H    sing N N 291 
SER N   H2   sing N N 292 
SER CA  C    sing N N 293 
SER CA  CB   sing N N 294 
SER CA  HA   sing N N 295 
SER C   O    doub N N 296 
SER C   OXT  sing N N 297 
SER CB  OG   sing N N 298 
SER CB  HB2  sing N N 299 
SER CB  HB3  sing N N 300 
SER OG  HG   sing N N 301 
SER OXT HXT  sing N N 302 
THR N   CA   sing N N 303 
THR N   H    sing N N 304 
THR N   H2   sing N N 305 
THR CA  C    sing N N 306 
THR CA  CB   sing N N 307 
THR CA  HA   sing N N 308 
THR C   O    doub N N 309 
THR C   OXT  sing N N 310 
THR CB  OG1  sing N N 311 
THR CB  CG2  sing N N 312 
THR CB  HB   sing N N 313 
THR OG1 HG1  sing N N 314 
THR CG2 HG21 sing N N 315 
THR CG2 HG22 sing N N 316 
THR CG2 HG23 sing N N 317 
THR OXT HXT  sing N N 318 
TRP N   CA   sing N N 319 
TRP N   H    sing N N 320 
TRP N   H2   sing N N 321 
TRP CA  C    sing N N 322 
TRP CA  CB   sing N N 323 
TRP CA  HA   sing N N 324 
TRP C   O    doub N N 325 
TRP C   OXT  sing N N 326 
TRP CB  CG   sing N N 327 
TRP CB  HB2  sing N N 328 
TRP CB  HB3  sing N N 329 
TRP CG  CD1  doub Y N 330 
TRP CG  CD2  sing Y N 331 
TRP CD1 NE1  sing Y N 332 
TRP CD1 HD1  sing N N 333 
TRP CD2 CE2  doub Y N 334 
TRP CD2 CE3  sing Y N 335 
TRP NE1 CE2  sing Y N 336 
TRP NE1 HE1  sing N N 337 
TRP CE2 CZ2  sing Y N 338 
TRP CE3 CZ3  doub Y N 339 
TRP CE3 HE3  sing N N 340 
TRP CZ2 CH2  doub Y N 341 
TRP CZ2 HZ2  sing N N 342 
TRP CZ3 CH2  sing Y N 343 
TRP CZ3 HZ3  sing N N 344 
TRP CH2 HH2  sing N N 345 
TRP OXT HXT  sing N N 346 
TYR N   CA   sing N N 347 
TYR N   H    sing N N 348 
TYR N   H2   sing N N 349 
TYR CA  C    sing N N 350 
TYR CA  CB   sing N N 351 
TYR CA  HA   sing N N 352 
TYR C   O    doub N N 353 
TYR C   OXT  sing N N 354 
TYR CB  CG   sing N N 355 
TYR CB  HB2  sing N N 356 
TYR CB  HB3  sing N N 357 
TYR CG  CD1  doub Y N 358 
TYR CG  CD2  sing Y N 359 
TYR CD1 CE1  sing Y N 360 
TYR CD1 HD1  sing N N 361 
TYR CD2 CE2  doub Y N 362 
TYR CD2 HD2  sing N N 363 
TYR CE1 CZ   doub Y N 364 
TYR CE1 HE1  sing N N 365 
TYR CE2 CZ   sing Y N 366 
TYR CE2 HE2  sing N N 367 
TYR CZ  OH   sing N N 368 
TYR OH  HH   sing N N 369 
TYR OXT HXT  sing N N 370 
VAL N   CA   sing N N 371 
VAL N   H    sing N N 372 
VAL N   H2   sing N N 373 
VAL CA  C    sing N N 374 
VAL CA  CB   sing N N 375 
VAL CA  HA   sing N N 376 
VAL C   O    doub N N 377 
VAL C   OXT  sing N N 378 
VAL CB  CG1  sing N N 379 
VAL CB  CG2  sing N N 380 
VAL CB  HB   sing N N 381 
VAL CG1 HG11 sing N N 382 
VAL CG1 HG12 sing N N 383 
VAL CG1 HG13 sing N N 384 
VAL CG2 HG21 sing N N 385 
VAL CG2 HG22 sing N N 386 
VAL CG2 HG23 sing N N 387 
VAL OXT HXT  sing N N 388 
# 
_pdbx_audit_support.funding_organization   'Japan Society for the Promotion of Science (JSPS)' 
_pdbx_audit_support.country                Japan 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 1 21 1' 
_space_group.name_Hall        'P 2yb' 
_space_group.IT_number        4 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9KS7 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.019406 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.001504 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013818 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011315 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CA ? ? 16.26893 3.65395 ? ? 3.58509  77.28589 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ASN A 1 9   ? 4.85146   10.46094  9.53377   1.000 63.63633  ? 45  ASN A N   1 
ATOM   2    C  CA  . ASN A 1 9   ? 6.10899   9.75549   9.30729   1.000 64.99442  ? 45  ASN A CA  1 
ATOM   3    C  C   . ASN A 1 9   ? 6.37804   8.73951   10.40955  1.000 60.17750  ? 45  ASN A C   1 
ATOM   4    O  O   . ASN A 1 9   ? 5.89071   7.59810   10.39353  1.000 60.38493  ? 45  ASN A O   1 
ATOM   5    C  CB  . ASN A 1 9   ? 7.27929   10.74791  9.23271   1.000 59.89175  ? 45  ASN A CB  1 
ATOM   6    C  CG  . ASN A 1 9   ? 7.91027   10.80305  7.85701   1.000 68.92779  ? 45  ASN A CG  1 
ATOM   7    O  OD1 . ASN A 1 9   ? 7.81255   9.85058   7.08291   1.000 74.75874  ? 45  ASN A OD1 1 
ATOM   8    N  ND2 . ASN A 1 9   ? 8.57162   11.91553  7.54704   1.000 65.74942  ? 45  ASN A ND2 1 
ATOM   9    N  N   . LYS A 1 10  ? 7.17517   9.17716   11.37733  1.000 59.67011  ? 46  LYS A N   1 
ATOM   10   C  CA  . LYS A 1 10  ? 7.48894   8.34719   12.52437  1.000 48.65806  ? 46  LYS A CA  1 
ATOM   11   C  C   . LYS A 1 10  ? 6.29989   8.18954   13.46457  1.000 49.82428  ? 46  LYS A C   1 
ATOM   12   O  O   . LYS A 1 10  ? 6.33508   7.31832   14.33949  1.000 43.32220  ? 46  LYS A O   1 
ATOM   13   C  CB  . LYS A 1 10  ? 8.69726   8.95098   13.23532  1.000 58.24205  ? 46  LYS A CB  1 
ATOM   14   C  CG  . LYS A 1 10  ? 9.72200   9.52123   12.24445  1.000 59.82724  ? 46  LYS A CG  1 
ATOM   15   C  CD  . LYS A 1 10  ? 11.14685  9.52873   12.78736  1.000 67.72186  ? 46  LYS A CD  1 
ATOM   16   C  CE  . LYS A 1 10  ? 12.14154  8.99024   11.76424  1.000 67.54065  ? 46  LYS A CE  1 
ATOM   17   N  NZ  . LYS A 1 10  ? 13.52260  8.92050   12.32066  1.000 61.56360  ? 46  LYS A NZ  1 
ATOM   18   N  N   . PHE A 1 11  ? 5.23462   8.97487   13.27331  1.000 40.33930  ? 47  PHE A N   1 
ATOM   19   C  CA  . PHE A 1 11  ? 4.09112   8.91879   14.17848  1.000 43.98240  ? 47  PHE A CA  1 
ATOM   20   C  C   . PHE A 1 11  ? 3.30059   7.62473   14.03789  1.000 52.07585  ? 47  PHE A C   1 
ATOM   21   O  O   . PHE A 1 11  ? 2.70796   7.15894   15.01761  1.000 57.40322  ? 47  PHE A O   1 
ATOM   22   C  CB  . PHE A 1 11  ? 3.19358   10.13209  13.95089  1.000 41.44421  ? 47  PHE A CB  1 
ATOM   23   C  CG  . PHE A 1 11  ? 3.69583   11.36417  14.63001  1.000 51.78304  ? 47  PHE A CG  1 
ATOM   24   C  CD1 . PHE A 1 11  ? 3.75231   11.42275  16.01429  1.000 47.24326  ? 47  PHE A CD1 1 
ATOM   25   C  CD2 . PHE A 1 11  ? 4.17030   12.43826  13.89476  1.000 49.08173  ? 47  PHE A CD2 1 
ATOM   26   C  CE1 . PHE A 1 11  ? 4.23754   12.54834  16.65777  1.000 44.08319  ? 47  PHE A CE1 1 
ATOM   27   C  CE2 . PHE A 1 11  ? 4.66104   13.56695  14.52954  1.000 49.05170  ? 47  PHE A CE2 1 
ATOM   28   C  CZ  . PHE A 1 11  ? 4.69790   13.61982  15.91363  1.000 45.36687  ? 47  PHE A CZ  1 
ATOM   29   N  N   . ASP A 1 12  ? 3.26815   7.02716   12.84725  1.000 46.65076  ? 48  ASP A N   1 
ATOM   30   C  CA  . ASP A 1 12  ? 2.63341   5.71737   12.73034  1.000 50.40672  ? 48  ASP A CA  1 
ATOM   31   C  C   . ASP A 1 12  ? 3.32108   4.68073   13.61012  1.000 51.32179  ? 48  ASP A C   1 
ATOM   32   O  O   . ASP A 1 12  ? 2.66790   3.75893   14.11209  1.000 47.87814  ? 48  ASP A O   1 
ATOM   33   C  CB  . ASP A 1 12  ? 2.61771   5.25429   11.27083  1.000 57.68388  ? 48  ASP A CB  1 
ATOM   34   C  CG  . ASP A 1 12  ? 1.31019   5.58065   10.57121  1.000 62.81952  ? 48  ASP A CG  1 
ATOM   35   O  OD1 . ASP A 1 12  ? 0.59989   6.49887   11.03462  1.000 71.76079  ? 48  ASP A OD1 1 
ATOM   36   O  OD2 . ASP A 1 12  ? 0.98403   4.90678   9.56827   1.000 70.60122  ? 48  ASP A OD2 1 
ATOM   37   N  N   . LYS A 1 13  ? 4.63278   4.80279   13.80702  1.000 39.38183  ? 49  LYS A N   1 
ATOM   38   C  CA  . LYS A 1 13  ? 5.28874   3.92176   14.76234  1.000 45.52531  ? 49  LYS A CA  1 
ATOM   39   C  C   . LYS A 1 13  ? 4.99250   4.35689   16.19356  1.000 36.37724  ? 49  LYS A C   1 
ATOM   40   O  O   . LYS A 1 13  ? 4.81575   3.51159   17.07985  1.000 41.88774  ? 49  LYS A O   1 
ATOM   41   C  CB  . LYS A 1 13  ? 6.79801   3.89113   14.50571  1.000 37.68776  ? 49  LYS A CB  1 
ATOM   42   C  CG  . LYS A 1 13  ? 7.17673   3.61356   13.05728  1.000 48.04578  ? 49  LYS A CG  1 
ATOM   43   C  CD  . LYS A 1 13  ? 8.66324   3.34130   12.89621  1.000 50.91741  ? 49  LYS A CD  1 
ATOM   44   C  CE  . LYS A 1 13  ? 8.97687   2.87835   11.47189  1.000 58.35302  ? 49  LYS A CE  1 
ATOM   45   N  NZ  . LYS A 1 13  ? 9.06887   1.39235   11.32582  1.000 55.96061  ? 49  LYS A NZ  1 
ATOM   46   N  N   . LEU A 1 14  ? 4.91829   5.67171   16.43798  1.000 35.21374  ? 50  LEU A N   1 
ATOM   47   C  CA  . LEU A 1 14  ? 4.91983   6.16956   17.81160  1.000 31.18294  ? 50  LEU A CA  1 
ATOM   48   C  C   . LEU A 1 14  ? 3.53154   6.22269   18.43708  1.000 27.06969  ? 50  LEU A C   1 
ATOM   49   O  O   . LEU A 1 14  ? 3.38513   5.86285   19.60987  1.000 28.80239  ? 50  LEU A O   1 
ATOM   50   C  CB  . LEU A 1 14  ? 5.56962   7.56013   17.87836  1.000 22.92462  ? 50  LEU A CB  1 
ATOM   51   C  CG  . LEU A 1 14  ? 7.04580   7.64495   17.46582  1.000 24.14020  ? 50  LEU A CG  1 
ATOM   52   C  CD1 . LEU A 1 14  ? 7.62201   9.04128   17.69393  1.000 27.68954  ? 50  LEU A CD1 1 
ATOM   53   C  CD2 . LEU A 1 14  ? 7.90603   6.57324   18.16823  1.000 30.37480  ? 50  LEU A CD2 1 
ATOM   54   N  N   . ASP A 1 15  ? 2.51409   6.64674   17.68055  1.000 26.95846  ? 51  ASP A N   1 
ATOM   55   C  CA  . ASP A 1 15  ? 1.19675   6.90227   18.27273  1.000 28.04172  ? 51  ASP A CA  1 
ATOM   56   C  C   . ASP A 1 15  ? 0.57961   5.73649   19.04067  1.000 30.94678  ? 51  ASP A C   1 
ATOM   57   O  O   . ASP A 1 15  ? -0.05535  5.99802   20.07732  1.000 31.04979  ? 51  ASP A O   1 
ATOM   58   C  CB  . ASP A 1 15  ? 0.21518   7.38507   17.19591  1.000 37.09927  ? 51  ASP A CB  1 
ATOM   59   C  CG  . ASP A 1 15  ? 0.47035   8.81235   16.77456  1.000 43.43528  ? 51  ASP A CG  1 
ATOM   60   O  OD1 . ASP A 1 15  ? 0.00535   9.20513   15.68764  1.000 54.78537  ? 51  ASP A OD1 1 
ATOM   61   O  OD2 . ASP A 1 15  ? 1.11509   9.55495   17.54380  1.000 50.06851  ? 51  ASP A OD2 1 
ATOM   62   N  N   . PRO A 1 16  ? 0.67306   4.47391   18.60654  1.000 32.70701  ? 52  PRO A N   1 
ATOM   63   C  CA  . PRO A 1 16  ? 0.12834   3.39362   19.45205  1.000 33.96299  ? 52  PRO A CA  1 
ATOM   64   C  C   . PRO A 1 16  ? 0.82112   3.27240   20.80172  1.000 33.41956  ? 52  PRO A C   1 
ATOM   65   O  O   . PRO A 1 16  ? 0.16012   2.94704   21.79766  1.000 29.47905  ? 52  PRO A O   1 
ATOM   66   C  CB  . PRO A 1 16  ? 0.31194   2.12851   18.59960  1.000 35.38270  ? 52  PRO A CB  1 
ATOM   67   C  CG  . PRO A 1 16  ? 0.64112   2.58453   17.23535  1.000 38.97154  ? 52  PRO A CG  1 
ATOM   68   C  CD  . PRO A 1 16  ? 1.14009   3.98561   17.29443  1.000 37.82920  ? 52  PRO A CD  1 
ATOM   69   N  N   . TYR A 1 17  ? 2.12846   3.54016   20.87801  1.000 27.92186  ? 53  TYR A N   1 
ATOM   70   C  CA  . TYR A 1 17  ? 2.78338   3.55973   22.18281  1.000 27.57816  ? 53  TYR A CA  1 
ATOM   71   C  C   . TYR A 1 17  ? 2.48634   4.82429   22.97420  1.000 24.87467  ? 53  TYR A C   1 
ATOM   72   O  O   . TYR A 1 17  ? 2.30915   4.74696   24.19920  1.000 24.17474  ? 53  TYR A O   1 
ATOM   73   C  CB  . TYR A 1 17  ? 4.28729   3.32904   22.03609  1.000 29.44749  ? 53  TYR A CB  1 
ATOM   74   C  CG  . TYR A 1 17  ? 4.58021   1.91800   21.59609  1.000 36.66605  ? 53  TYR A CG  1 
ATOM   75   C  CD1 . TYR A 1 17  ? 4.73102   0.91514   22.55379  1.000 40.00942  ? 53  TYR A CD1 1 
ATOM   76   C  CD2 . TYR A 1 17  ? 4.63005   1.56849   20.25673  1.000 41.74659  ? 53  TYR A CD2 1 
ATOM   77   C  CE1 . TYR A 1 17  ? 4.97053   -0.39091  22.19035  1.000 50.63891  ? 53  TYR A CE1 1 
ATOM   78   C  CE2 . TYR A 1 17  ? 4.86870   0.25815   19.88000  1.000 45.88637  ? 53  TYR A CE2 1 
ATOM   79   C  CZ  . TYR A 1 17  ? 5.03519   -0.71424  20.85237  1.000 48.71764  ? 53  TYR A CZ  1 
ATOM   80   O  OH  . TYR A 1 17  ? 5.26835   -2.02494  20.50005  1.000 71.32823  ? 53  TYR A OH  1 
ATOM   81   N  N   . PHE A 1 18  ? 2.44184   5.99622   22.31944  1.000 22.99030  ? 54  PHE A N   1 
ATOM   82   C  CA  . PHE A 1 18  ? 1.99496   7.18866   23.04044  1.000 19.91890  ? 54  PHE A CA  1 
ATOM   83   C  C   . PHE A 1 18  ? 0.63071   6.93236   23.66517  1.000 22.66422  ? 54  PHE A C   1 
ATOM   84   O  O   . PHE A 1 18  ? 0.36375   7.34141   24.79869  1.000 21.43250  ? 54  PHE A O   1 
ATOM   85   C  CB  . PHE A 1 18  ? 1.88848   8.41203   22.12116  1.000 18.83221  ? 54  PHE A CB  1 
ATOM   86   C  CG  . PHE A 1 18  ? 3.20008   8.97600   21.64084  1.000 18.21495  ? 54  PHE A CG  1 
ATOM   87   C  CD1 . PHE A 1 18  ? 4.37058   8.83427   22.37500  1.000 18.77175  ? 54  PHE A CD1 1 
ATOM   88   C  CD2 . PHE A 1 18  ? 3.23193   9.72666   20.45674  1.000 18.29613  ? 54  PHE A CD2 1 
ATOM   89   C  CE1 . PHE A 1 18  ? 5.57087   9.37682   21.91403  1.000 18.41093  ? 54  PHE A CE1 1 
ATOM   90   C  CE2 . PHE A 1 18  ? 4.41293   10.28522  19.99550  1.000 16.40435  ? 54  PHE A CE2 1 
ATOM   91   C  CZ  . PHE A 1 18  ? 5.59133   10.11590  20.72412  1.000 17.20269  ? 54  PHE A CZ  1 
ATOM   92   N  N   . GLN A 1 19  ? -0.22949  6.21739   22.93865  1.000 25.93684  ? 55  GLN A N   1 
ATOM   93   C  CA  . GLN A 1 19  ? -1.58296  5.94708   23.41110  1.000 32.26550  ? 55  GLN A CA  1 
ATOM   94   C  C   . GLN A 1 19  ? -1.58150  5.10018   24.68099  1.000 39.96730  ? 55  GLN A C   1 
ATOM   95   O  O   . GLN A 1 19  ? -2.53267  5.16051   25.47038  1.000 34.33687  ? 55  GLN A O   1 
ATOM   96   C  CB  . GLN A 1 19  ? -2.35747  5.26316   22.28604  1.000 35.56537  ? 55  GLN A CB  1 
ATOM   97   C  CG  . GLN A 1 19  ? -3.01055  6.25237   21.32918  1.000 44.35295  ? 55  GLN A CG  1 
ATOM   98   C  CD  . GLN A 1 19  ? -4.00164  5.59623   20.38540  1.000 56.80874  ? 55  GLN A CD  1 
ATOM   99   O  OE1 . GLN A 1 19  ? -4.65584  6.27233   19.59006  1.000 66.58523  ? 55  GLN A OE1 1 
ATOM   100  N  NE2 . GLN A 1 19  ? -4.10865  4.27325   20.45930  1.000 55.93073  ? 55  GLN A NE2 1 
ATOM   101  N  N   . GLN A 1 20  ? -0.52660  4.31733   24.90395  1.000 23.31801  ? 56  GLN A N   1 
ATOM   102  C  CA  . GLN A 1 20  ? -0.37239  3.54458   26.13137  1.000 30.65202  ? 56  GLN A CA  1 
ATOM   103  C  C   . GLN A 1 20  ? 0.51614   4.23985   27.16448  1.000 33.33937  ? 56  GLN A C   1 
ATOM   104  O  O   . GLN A 1 20  ? 0.86052   3.62908   28.18304  1.000 33.07644  ? 56  GLN A O   1 
ATOM   105  C  CB  . GLN A 1 20  ? 0.18684   2.15593   25.81440  1.000 33.86979  ? 56  GLN A CB  1 
ATOM   106  C  CG  . GLN A 1 20  ? -0.86308  1.16324   25.32517  1.000 41.98173  ? 56  GLN A CG  1 
ATOM   107  C  CD  . GLN A 1 20  ? -0.38098  -0.28290  25.36555  1.000 67.54493  ? 56  GLN A CD  1 
ATOM   108  O  OE1 . GLN A 1 20  ? -0.08455  -0.88202  24.32826  1.000 73.58053  ? 56  GLN A OE1 1 
ATOM   109  N  NE2 . GLN A 1 20  ? -0.30759  -0.85222  26.56921  1.000 66.21943  ? 56  GLN A NE2 1 
ATOM   110  N  N   . GLY A 1 21  ? 0.90296   5.49261   26.92604  1.000 23.38123  ? 57  GLY A N   1 
ATOM   111  C  CA  . GLY A 1 21  ? 1.67578   6.25080   27.89124  1.000 22.54591  ? 57  GLY A CA  1 
ATOM   112  C  C   . GLY A 1 21  ? 3.18331   6.14952   27.74492  1.000 21.02786  ? 57  GLY A C   1 
ATOM   113  O  O   . GLY A 1 21  ? 3.90958   6.62907   28.62999  1.000 22.65519  ? 57  GLY A O   1 
ATOM   114  N  N   . TRP A 1 22  ? 3.67526   5.52965   26.67499  1.000 18.61726  ? 58  TRP A N   1 
ATOM   115  C  CA  . TRP A 1 22  ? 5.10575   5.56005   26.39326  1.000 17.68133  ? 58  TRP A CA  1 
ATOM   116  C  C   . TRP A 1 22  ? 5.50840   6.92843   25.85048  1.000 17.48892  ? 58  TRP A C   1 
ATOM   117  O  O   . TRP A 1 22  ? 4.67996   7.68496   25.34081  1.000 18.20381  ? 58  TRP A O   1 
ATOM   118  C  CB  . TRP A 1 22  ? 5.47582   4.49105   25.36620  1.000 18.95788  ? 58  TRP A CB  1 
ATOM   119  C  CG  . TRP A 1 22  ? 5.24384   3.08520   25.85155  1.000 24.81593  ? 58  TRP A CG  1 
ATOM   120  C  CD1 . TRP A 1 22  ? 4.04689   2.52651   26.23332  1.000 25.87485  ? 58  TRP A CD1 1 
ATOM   121  C  CD2 . TRP A 1 22  ? 6.23421   2.06293   26.01001  1.000 19.05669  ? 58  TRP A CD2 1 
ATOM   122  N  NE1 . TRP A 1 22  ? 4.23949   1.21389   26.63008  1.000 24.54815  ? 58  TRP A NE1 1 
ATOM   123  C  CE2 . TRP A 1 22  ? 5.57059   0.90505   26.49661  1.000 20.90304  ? 58  TRP A CE2 1 
ATOM   124  C  CE3 . TRP A 1 22  ? 7.62156   2.01286   25.79554  1.000 15.99136  ? 58  TRP A CE3 1 
ATOM   125  C  CZ2 . TRP A 1 22  ? 6.24020   -0.28549  26.75817  1.000 19.63328  ? 58  TRP A CZ2 1 
ATOM   126  C  CZ3 . TRP A 1 22  ? 8.28310   0.81446   26.04832  1.000 18.20704  ? 58  TRP A CZ3 1 
ATOM   127  C  CH2 . TRP A 1 22  ? 7.59457   -0.31384  26.53089  1.000 20.14730  ? 58  TRP A CH2 1 
ATOM   128  N  N   . PHE A 1 23  ? 6.80481   7.23531   25.92824  1.000 16.34107  ? 59  PHE A N   1 
ATOM   129  C  CA  . PHE A 1 23  ? 7.27854   8.51512   25.40974  1.000 14.66779  ? 59  PHE A CA  1 
ATOM   130  C  C   . PHE A 1 23  ? 8.65384   8.33573   24.78113  1.000 14.55696  ? 59  PHE A C   1 
ATOM   131  O  O   . PHE A 1 23  ? 9.36377   7.35947   25.03743  1.000 16.14647  ? 59  PHE A O   1 
ATOM   132  C  CB  . PHE A 1 23  ? 7.27735   9.59336   26.51797  1.000 17.39737  ? 59  PHE A CB  1 
ATOM   133  C  CG  . PHE A 1 23  ? 7.91946   9.13995   27.81865  1.000 17.04219  ? 59  PHE A CG  1 
ATOM   134  C  CD1 . PHE A 1 23  ? 7.16404   8.46459   28.78340  1.000 20.15130  ? 59  PHE A CD1 1 
ATOM   135  C  CD2 . PHE A 1 23  ? 9.26356   9.39635   28.07109  1.000 16.98792  ? 59  PHE A CD2 1 
ATOM   136  C  CE1 . PHE A 1 23  ? 7.74660   8.03596   29.98681  1.000 18.76667  ? 59  PHE A CE1 1 
ATOM   137  C  CE2 . PHE A 1 23  ? 9.85735   8.98273   29.27279  1.000 19.22263  ? 59  PHE A CE2 1 
ATOM   138  C  CZ  . PHE A 1 23  ? 9.09925   8.31540   30.22504  1.000 21.29946  ? 59  PHE A CZ  1 
ATOM   139  N  N   . HIS A 1 24  ? 9.03058   9.30434   23.95629  1.000 14.68117  ? 60  HIS A N   1 
ATOM   140  C  CA  . HIS A 1 24  ? 10.10422  9.13558   22.98712  1.000 14.83245  ? 60  HIS A CA  1 
ATOM   141  C  C   . HIS A 1 24  ? 11.32861  9.97739   23.33870  1.000 13.94123  ? 60  HIS A C   1 
ATOM   142  O  O   . HIS A 1 24  ? 11.23274  11.19709  23.52695  1.000 16.16440  ? 60  HIS A O   1 
ATOM   143  C  CB  . HIS A 1 24  ? 9.55185   9.48841   21.59543  1.000 14.66474  ? 60  HIS A CB  1 
ATOM   144  C  CG  . HIS A 1 24  ? 10.60605  9.70714   20.55381  1.000 18.31131  ? 60  HIS A CG  1 
ATOM   145  N  ND1 . HIS A 1 24  ? 10.49590  10.68613  19.58605  1.000 17.39404  ? 60  HIS A ND1 1 
ATOM   146  C  CD2 . HIS A 1 24  ? 11.77418  9.06491   20.31170  1.000 17.70212  ? 60  HIS A CD2 1 
ATOM   147  C  CE1 . HIS A 1 24  ? 11.56455  10.65262  18.80982  1.000 19.29897  ? 60  HIS A CE1 1 
ATOM   148  N  NE2 . HIS A 1 24  ? 12.36182  9.68930   19.23639  1.000 20.67652  ? 60  HIS A NE2 1 
ATOM   149  N  N   . PHE A 1 25  ? 12.49160  9.32892   23.38902  1.000 14.68466  ? 61  PHE A N   1 
ATOM   150  C  CA  . PHE A 1 25  ? 13.74452  10.02528  23.62662  1.000 13.09750  ? 61  PHE A CA  1 
ATOM   151  C  C   . PHE A 1 25  ? 14.81408  9.35793   22.76149  1.000 16.50596  ? 61  PHE A C   1 
ATOM   152  O  O   . PHE A 1 25  ? 14.96514  8.12901   22.79279  1.000 16.33986  ? 61  PHE A O   1 
ATOM   153  C  CB  . PHE A 1 25  ? 14.08355  10.00061  25.14647  1.000 17.41663  ? 61  PHE A CB  1 
ATOM   154  C  CG  . PHE A 1 25  ? 15.41996  10.57264  25.48365  1.000 15.08667  ? 61  PHE A CG  1 
ATOM   155  C  CD1 . PHE A 1 25  ? 15.58881  11.94963  25.62190  1.000 18.46084  ? 61  PHE A CD1 1 
ATOM   156  C  CD2 . PHE A 1 25  ? 16.51743  9.73426   25.67481  1.000 17.32216  ? 61  PHE A CD2 1 
ATOM   157  C  CE1 . PHE A 1 25  ? 16.84739  12.47868  25.93900  1.000 21.59988  ? 61  PHE A CE1 1 
ATOM   158  C  CE2 . PHE A 1 25  ? 17.77709  10.25768  25.98489  1.000 20.19888  ? 61  PHE A CE2 1 
ATOM   159  C  CZ  . PHE A 1 25  ? 17.94183  11.61939  26.11617  1.000 20.62579  ? 61  PHE A CZ  1 
ATOM   160  N  N   . GLN A 1 26  ? 15.50396  10.16146  21.94019  1.000 18.71658  ? 62  GLN A N   1 
ATOM   161  C  CA  . GLN A 1 26  ? 16.53213  9.68949   20.99400  1.000 19.40850  ? 62  GLN A CA  1 
ATOM   162  C  C   . GLN A 1 26  ? 15.90354  8.66251   20.05914  1.000 20.81157  ? 62  GLN A C   1 
ATOM   163  O  O   . GLN A 1 26  ? 15.00337  9.01656   19.27991  1.000 23.61147  ? 62  GLN A O   1 
ATOM   164  C  CB  . GLN A 1 26  ? 17.76044  9.20194   21.75938  1.000 21.21219  ? 62  GLN A CB  1 
ATOM   165  C  CG  . GLN A 1 26  ? 18.46810  10.30053  22.52212  1.000 23.28252  ? 62  GLN A CG  1 
ATOM   166  C  CD  . GLN A 1 26  ? 19.76005  9.83114   23.14637  1.000 25.01837  ? 62  GLN A CD  1 
ATOM   167  O  OE1 . GLN A 1 26  ? 19.82944  8.75913   23.77248  1.000 27.65864  ? 62  GLN A OE1 1 
ATOM   168  N  NE2 . GLN A 1 26  ? 20.80182  10.62475  22.97277  1.000 26.16052  ? 62  GLN A NE2 1 
ATOM   169  N  N   . LYS A 1 27  ? 16.33855  7.41193   20.06211  1.000 20.31949  ? 63  LYS A N   1 
ATOM   170  C  CA  . LYS A 1 27  ? 15.79987  6.44852   19.11218  1.000 23.63963  ? 63  LYS A CA  1 
ATOM   171  C  C   . LYS A 1 27  ? 14.83239  5.47553   19.75265  1.000 23.16416  ? 63  LYS A C   1 
ATOM   172  O  O   . LYS A 1 27  ? 14.42097  4.50887   19.10260  1.000 19.46398  ? 63  LYS A O   1 
ATOM   173  C  CB  . LYS A 1 27  ? 16.94068  5.68912   18.43631  1.000 29.54045  ? 63  LYS A CB  1 
ATOM   174  C  CG  . LYS A 1 27  ? 17.99314  6.60791   17.84408  1.000 34.82438  ? 63  LYS A CG  1 
ATOM   175  C  CD  . LYS A 1 27  ? 18.79645  5.89104   16.76537  1.000 43.01638  ? 63  LYS A CD  1 
ATOM   176  C  CE  . LYS A 1 27  ? 19.78852  6.83367   16.10185  1.000 45.85274  ? 63  LYS A CE  1 
ATOM   177  N  NZ  . LYS A 1 27  ? 20.71294  6.10596   15.18547  1.000 49.19187  ? 63  LYS A NZ  1 
ATOM   178  N  N   . SER A 1 28  ? 14.42150  5.73145   20.99179  1.000 18.64981  ? 64  SER A N   1 
ATOM   179  C  CA  . SER A 1 28  ? 13.70207  4.74251   21.77004  1.000 16.88847  ? 64  SER A CA  1 
ATOM   180  C  C   . SER A 1 28  ? 12.39204  5.29720   22.29856  1.000 15.10394  ? 64  SER A C   1 
ATOM   181  O  O   . SER A 1 28  ? 12.20873  6.51071   22.43461  1.000 15.17640  ? 64  SER A O   1 
ATOM   182  C  CB  . SER A 1 28  ? 14.54247  4.26081   22.96218  1.000 18.63764  ? 64  SER A CB  1 
ATOM   183  O  OG  . SER A 1 28  ? 15.71233  3.57389   22.52628  1.000 18.97093  ? 64  SER A OG  1 
ATOM   184  N  N   . LEU A 1 29  ? 11.49548  4.37094   22.61823  1.000 15.63043  ? 65  LEU A N   1 
ATOM   185  C  CA  . LEU A 1 29  ? 10.31703  4.65975   23.41707  1.000 14.55065  ? 65  LEU A CA  1 
ATOM   186  C  C   . LEU A 1 29  ? 10.55579  4.12238   24.82704  1.000 15.35311  ? 65  LEU A C   1 
ATOM   187  O  O   . LEU A 1 29  ? 11.18515  3.07440   25.00729  1.000 14.68004  ? 65  LEU A O   1 
ATOM   188  C  CB  . LEU A 1 29  ? 9.07878   3.99039   22.83452  1.000 17.11004  ? 65  LEU A CB  1 
ATOM   189  C  CG  . LEU A 1 29  ? 8.46057   4.68127   21.61931  1.000 17.56895  ? 65  LEU A CG  1 
ATOM   190  C  CD1 . LEU A 1 29  ? 7.62824   3.67270   20.82684  1.000 18.77596  ? 65  LEU A CD1 1 
ATOM   191  C  CD2 . LEU A 1 29  ? 7.59933   5.87472   22.06049  1.000 18.47983  ? 65  LEU A CD2 1 
ATOM   192  N  N   . TYR A 1 30  ? 10.04587  4.83696   25.82822  1.000 15.20110  ? 66  TYR A N   1 
ATOM   193  C  CA  . TYR A 1 30  ? 10.27870  4.45814   27.21309  1.000 15.25161  ? 66  TYR A CA  1 
ATOM   194  C  C   . TYR A 1 30  ? 8.94828   4.38966   27.93625  1.000 15.73322  ? 66  TYR A C   1 
ATOM   195  O  O   . TYR A 1 30  ? 7.99710   5.09602   27.58681  1.000 15.47878  ? 66  TYR A O   1 
ATOM   196  C  CB  . TYR A 1 30  ? 11.17866  5.45086   27.96511  1.000 16.14183  ? 66  TYR A CB  1 
ATOM   197  C  CG  . TYR A 1 30  ? 12.57396  5.55735   27.40017  1.000 16.90083  ? 66  TYR A CG  1 
ATOM   198  C  CD1 . TYR A 1 30  ? 12.82379  6.34302   26.27892  1.000 13.79275  ? 66  TYR A CD1 1 
ATOM   199  C  CD2 . TYR A 1 30  ? 13.62815  4.85558   27.97300  1.000 15.31633  ? 66  TYR A CD2 1 
ATOM   200  C  CE1 . TYR A 1 30  ? 14.12180  6.46061   25.75765  1.000 14.91269  ? 66  TYR A CE1 1 
ATOM   201  C  CE2 . TYR A 1 30  ? 14.92997  4.94432   27.45039  1.000 11.95254  ? 66  TYR A CE2 1 
ATOM   202  C  CZ  . TYR A 1 30  ? 15.15982  5.75533   26.33839  1.000 15.60410  ? 66  TYR A CZ  1 
ATOM   203  O  OH  . TYR A 1 30  ? 16.44050  5.86511   25.83057  1.000 16.45103  ? 66  TYR A OH  1 
ATOM   204  N  N   . TYR A 1 31  ? 8.90348   3.53845   28.95834  1.000 16.34889  ? 67  TYR A N   1 
ATOM   205  C  CA  . TYR A 1 31  ? 7.70742   3.34166   29.76682  1.000 15.41274  ? 67  TYR A CA  1 
ATOM   206  C  C   . TYR A 1 31  ? 8.10909   3.35145   31.23078  1.000 16.07037  ? 67  TYR A C   1 
ATOM   207  O  O   . TYR A 1 31  ? 9.03164   2.63519   31.61726  1.000 17.15164  ? 67  TYR A O   1 
ATOM   208  C  CB  . TYR A 1 31  ? 7.04514   2.02191   29.39216  1.000 20.58436  ? 67  TYR A CB  1 
ATOM   209  C  CG  . TYR A 1 31  ? 5.88019   1.62570   30.26292  1.000 18.57380  ? 67  TYR A CG  1 
ATOM   210  C  CD1 . TYR A 1 31  ? 4.58630   2.02791   29.95732  1.000 30.71838  ? 67  TYR A CD1 1 
ATOM   211  C  CD2 . TYR A 1 31  ? 6.08208   0.79843   31.35799  1.000 23.39565  ? 67  TYR A CD2 1 
ATOM   212  C  CE1 . TYR A 1 31  ? 3.51636   1.62887   30.75193  1.000 28.78265  ? 67  TYR A CE1 1 
ATOM   213  C  CE2 . TYR A 1 31  ? 5.02777   0.39555   32.14760  1.000 29.39414  ? 67  TYR A CE2 1 
ATOM   214  C  CZ  . TYR A 1 31  ? 3.75168   0.81603   31.83919  1.000 25.31524  ? 67  TYR A CZ  1 
ATOM   215  O  OH  . TYR A 1 31  ? 2.70541   0.40856   32.64139  1.000 48.93275  ? 67  TYR A OH  1 
ATOM   216  N  N   . ILE A 1 32  ? 7.44458   4.17652   32.03873  1.000 15.17032  ? 68  ILE A N   1 
ATOM   217  C  CA  . ILE A 1 32  ? 7.64761   4.16502   33.48787  1.000 13.32745  ? 68  ILE A CA  1 
ATOM   218  C  C   . ILE A 1 32  ? 6.44741   3.45371   34.11149  1.000 16.58603  ? 68  ILE A C   1 
ATOM   219  O  O   . ILE A 1 32  ? 5.29848   3.79006   33.80702  1.000 17.61535  ? 68  ILE A O   1 
ATOM   220  C  CB  . ILE A 1 32  ? 7.82067   5.59479   34.03226  1.000 14.49519  ? 68  ILE A CB  1 
ATOM   221  C  CG1 . ILE A 1 32  ? 9.19244   6.16283   33.60385  1.000 15.11821  ? 68  ILE A CG1 1 
ATOM   222  C  CG2 . ILE A 1 32  ? 7.70125   5.61472   35.55636  1.000 13.88339  ? 68  ILE A CG2 1 
ATOM   223  C  CD1 . ILE A 1 32  ? 9.41094   7.61540   33.99095  1.000 16.38258  ? 68  ILE A CD1 1 
ATOM   224  N  N   . SER A 1 33  ? 6.70521   2.42468   34.92347  1.000 12.40469  ? 69  SER A N   1 
ATOM   225  C  CA  . SER A 1 33  ? 5.59439   1.63720   35.44941  1.000 12.34426  ? 69  SER A CA  1 
ATOM   226  C  C   . SER A 1 33  ? 4.80171   2.44924   36.46211  1.000 15.46851  ? 69  SER A C   1 
ATOM   227  O  O   . SER A 1 33  ? 5.28483   3.44220   37.01910  1.000 14.38301  ? 69  SER A O   1 
ATOM   228  C  CB  . SER A 1 33  ? 6.09711   0.36310   36.13020  1.000 12.51258  ? 69  SER A CB  1 
ATOM   229  O  OG  . SER A 1 33  ? 6.83682   0.69658   37.29035  1.000 13.89417  ? 69  SER A OG  1 
ATOM   230  N  N   . SER A 1 34  ? 3.56039   2.00811   36.68959  1.000 17.05395  ? 70  SER A N   1 
ATOM   231  C  CA  A SER A 1 34  ? 2.73041   2.57853   37.74019  0.739 18.84501  ? 70  SER A CA  1 
ATOM   232  C  CA  B SER A 1 34  ? 2.67504   2.54464   37.71162  0.261 18.88625  ? 70  SER A CA  1 
ATOM   233  C  C   . SER A 1 34  ? 2.59832   1.64800   38.94019  1.000 18.09236  ? 70  SER A C   1 
ATOM   234  O  O   . SER A 1 34  ? 1.88720   1.98531   39.89926  1.000 20.17564  ? 70  SER A O   1 
ATOM   235  C  CB  A SER A 1 34  ? 1.34217   2.92686   37.18577  0.739 23.86515  ? 70  SER A CB  1 
ATOM   236  C  CB  B SER A 1 34  ? 1.26696   2.73355   37.13690  0.261 23.60618  ? 70  SER A CB  1 
ATOM   237  O  OG  A SER A 1 34  ? 0.73915   1.78892   36.60380  0.739 26.11164  ? 70  SER A OG  1 
ATOM   238  O  OG  B SER A 1 34  ? 1.26795   3.67749   36.08697  0.261 21.21937  ? 70  SER A OG  1 
ATOM   239  N  N   . VAL A 1 35  ? 3.27434   0.49981   38.91101  1.000 13.31234  ? 71  VAL A N   1 
ATOM   240  C  CA  . VAL A 1 35  ? 3.34386   -0.44613  40.01798  1.000 12.49212  ? 71  VAL A CA  1 
ATOM   241  C  C   . VAL A 1 35  ? 4.81360   -0.77639  40.23798  1.000 13.26451  ? 71  VAL A C   1 
ATOM   242  O  O   . VAL A 1 35  ? 5.64646   -0.62940  39.33992  1.000 15.86897  ? 71  VAL A O   1 
ATOM   243  C  CB  . VAL A 1 35  ? 2.55695   -1.74859  39.74286  1.000 16.23596  ? 71  VAL A CB  1 
ATOM   244  C  CG1 . VAL A 1 35  ? 1.04142   -1.44351  39.60788  1.000 18.11792  ? 71  VAL A CG1 1 
ATOM   245  C  CG2 . VAL A 1 35  ? 3.10223   -2.46512  38.50074  1.000 16.67760  ? 71  VAL A CG2 1 
ATOM   246  N  N   . LYS A 1 36  ? 5.12548   -1.23207  41.44794  1.000 13.94238  ? 72  LYS A N   1 
ATOM   247  C  CA  . LYS A 1 36  ? 6.46730   -1.72431  41.73146  1.000 13.97572  ? 72  LYS A CA  1 
ATOM   248  C  C   . LYS A 1 36  ? 6.49572   -3.23323  41.51453  1.000 16.67914  ? 72  LYS A C   1 
ATOM   249  O  O   . LYS A 1 36  ? 5.47237   -3.91692  41.61201  1.000 15.19933  ? 72  LYS A O   1 
ATOM   250  C  CB  . LYS A 1 36  ? 6.87339   -1.41155  43.17634  1.000 13.03867  ? 72  LYS A CB  1 
ATOM   251  C  CG  . LYS A 1 36  ? 6.89732   0.10149   43.49316  1.000 14.30583  ? 72  LYS A CG  1 
ATOM   252  C  CD  . LYS A 1 36  ? 7.63798   0.39865   44.79405  1.000 15.42274  ? 72  LYS A CD  1 
ATOM   253  C  CE  . LYS A 1 36  ? 7.86984   1.92152   44.95369  1.000 18.65342  ? 72  LYS A CE  1 
ATOM   254  N  NZ  . LYS A 1 36  ? 8.52372   2.26403   46.27057  1.000 18.69201  ? 72  LYS A NZ  1 
ATOM   255  N  N   . ASN A 1 37  ? 7.68608   -3.76375  41.25583  1.000 14.02031  ? 73  ASN A N   1 
ATOM   256  C  CA  . ASN A 1 37  ? 7.76788   -5.21280  41.14406  1.000 12.75780  ? 73  ASN A CA  1 
ATOM   257  C  C   . ASN A 1 37  ? 9.21190   -5.65343  41.33685  1.000 13.22774  ? 73  ASN A C   1 
ATOM   258  O  O   . ASN A 1 37  ? 10.13006  -4.83184  41.36301  1.000 14.20019  ? 73  ASN A O   1 
ATOM   259  C  CB  . ASN A 1 37  ? 7.22935   -5.68613  39.79807  1.000 12.62043  ? 73  ASN A CB  1 
ATOM   260  C  CG  . ASN A 1 37  ? 6.35523   -6.89552  39.95866  1.000 13.90897  ? 73  ASN A CG  1 
ATOM   261  O  OD1 . ASN A 1 37  ? 6.58777   -7.71479  40.86753  1.000 16.47538  ? 73  ASN A OD1 1 
ATOM   262  N  ND2 . ASN A 1 37  ? 5.34260   -7.01640  39.12239  1.000 15.86920  ? 73  ASN A ND2 1 
ATOM   263  N  N   . THR A 1 38  ? 9.39456   -6.96870  41.50361  1.000 13.70961  ? 74  THR A N   1 
ATOM   264  C  CA  . THR A 1 38  ? 10.74669  -7.51780  41.55150  1.000 16.35331  ? 74  THR A CA  1 
ATOM   265  C  C   . THR A 1 38  ? 11.45129  -7.24723  40.22447  1.000 14.69526  ? 74  THR A C   1 
ATOM   266  O  O   . THR A 1 38  ? 10.81887  -6.96746  39.19720  1.000 16.14258  ? 74  THR A O   1 
ATOM   267  C  CB  . THR A 1 38  ? 10.72656  -9.02482  41.78942  1.000 18.19733  ? 74  THR A CB  1 
ATOM   268  O  OG1 . THR A 1 38  ? 10.20902  -9.66728  40.60756  1.000 15.72805  ? 74  THR A OG1 1 
ATOM   269  C  CG2 . THR A 1 38  ? 9.84421   -9.39144  43.00038  1.000 15.00681  ? 74  THR A CG2 1 
ATOM   270  N  N   . TRP A 1 39  ? 12.78340  -7.36580  40.22728  1.000 12.37194  ? 75  TRP A N   1 
ATOM   271  C  CA  . TRP A 1 39  ? 13.48842  -7.10916  38.97269  1.000 14.28463  ? 75  TRP A CA  1 
ATOM   272  C  C   . TRP A 1 39  ? 12.99301  -8.04374  37.87896  1.000 12.85843  ? 75  TRP A C   1 
ATOM   273  O  O   . TRP A 1 39  ? 12.72896  -7.61210  36.75421  1.000 12.51616  ? 75  TRP A O   1 
ATOM   274  C  CB  . TRP A 1 39  ? 15.00263  -7.25933  39.16165  1.000 15.33915  ? 75  TRP A CB  1 
ATOM   275  C  CG  . TRP A 1 39  ? 15.84095  -6.81296  37.94682  1.000 14.05141  ? 75  TRP A CG  1 
ATOM   276  C  CD1 . TRP A 1 39  ? 16.38746  -5.57488  37.72783  1.000 11.84463  ? 75  TRP A CD1 1 
ATOM   277  C  CD2 . TRP A 1 39  ? 16.21372  -7.62088  36.82432  1.000 13.53151  ? 75  TRP A CD2 1 
ATOM   278  N  NE1 . TRP A 1 39  ? 17.11679  -5.57945  36.54843  1.000 15.26087  ? 75  TRP A NE1 1 
ATOM   279  C  CE2 . TRP A 1 39  ? 17.01914  -6.82246  35.97617  1.000 13.94499  ? 75  TRP A CE2 1 
ATOM   280  C  CE3 . TRP A 1 39  ? 15.96259  -8.95414  36.46266  1.000 15.26616  ? 75  TRP A CE3 1 
ATOM   281  C  CZ2 . TRP A 1 39  ? 17.53939  -7.30281  34.76508  1.000 16.03504  ? 75  TRP A CZ2 1 
ATOM   282  C  CZ3 . TRP A 1 39  ? 16.50060  -9.43710  35.27198  1.000 17.47950  ? 75  TRP A CZ3 1 
ATOM   283  C  CH2 . TRP A 1 39  ? 17.27595  -8.61097  34.43433  1.000 15.91480  ? 75  TRP A CH2 1 
ATOM   284  N  N   . HIS A 1 40  ? 12.81625  -9.32198  38.20526  1.000 15.02746  ? 76  HIS A N   1 
ATOM   285  C  CA  . HIS A 1 40  ? 12.46570  -10.29271 37.17603  1.000 15.65886  ? 76  HIS A CA  1 
ATOM   286  C  C   . HIS A 1 40  ? 11.04555  -10.08803 36.66739  1.000 14.70717  ? 76  HIS A C   1 
ATOM   287  O  O   . HIS A 1 40  ? 10.79112  -10.21683 35.46777  1.000 15.33341  ? 76  HIS A O   1 
ATOM   288  C  CB  . HIS A 1 40  ? 12.65112  -11.69730 37.73736  1.000 17.78513  ? 76  HIS A CB  1 
ATOM   289  C  CG  . HIS A 1 40  ? 14.09281  -12.05654 37.91242  1.000 20.47901  ? 76  HIS A CG  1 
ATOM   290  N  ND1 . HIS A 1 40  ? 14.77368  -11.84067 39.09082  1.000 24.35136  ? 76  HIS A ND1 1 
ATOM   291  C  CD2 . HIS A 1 40  ? 14.99564  -12.56609 37.04291  1.000 24.31875  ? 76  HIS A CD2 1 
ATOM   292  C  CE1 . HIS A 1 40  ? 16.03276  -12.21868 38.94316  1.000 23.64041  ? 76  HIS A CE1 1 
ATOM   293  N  NE2 . HIS A 1 40  ? 16.19176  -12.66657 37.71237  1.000 23.70878  ? 76  HIS A NE2 1 
ATOM   294  N  N   . LEU A 1 41  ? 10.11003  -9.77048  37.55074  1.000 15.64577  ? 77  LEU A N   1 
ATOM   295  C  CA  . LEU A 1 41  ? 8.74136   -9.55163  37.07720  1.000 15.13657  ? 77  LEU A CA  1 
ATOM   296  C  C   . LEU A 1 41  ? 8.60107   -8.20912  36.37800  1.000 13.65166  ? 77  LEU A C   1 
ATOM   297  O  O   . LEU A 1 41  ? 7.73184   -8.06175  35.50324  1.000 14.06039  ? 77  LEU A O   1 
ATOM   298  C  CB  . LEU A 1 41  ? 7.75352   -9.62489  38.24739  1.000 13.98086  ? 77  LEU A CB  1 
ATOM   299  C  CG  . LEU A 1 41  ? 7.60003   -11.04486 38.81042  1.000 16.74771  ? 77  LEU A CG  1 
ATOM   300  C  CD1 . LEU A 1 41  ? 6.67214   -11.05639 40.03350  1.000 20.01564  ? 77  LEU A CD1 1 
ATOM   301  C  CD2 . LEU A 1 41  ? 7.06611   -11.96418 37.71786  1.000 20.46536  ? 77  LEU A CD2 1 
ATOM   302  N  N   . SER A 1 42  ? 9.39579   -7.20861  36.79086  1.000 13.19662  ? 78  SER A N   1 
ATOM   303  C  CA  . SER A 1 42  ? 9.48811   -5.96984  36.02427  1.000 14.17563  ? 78  SER A CA  1 
ATOM   304  C  C   . SER A 1 42  ? 9.92512   -6.27246  34.59673  1.000 14.19058  ? 78  SER A C   1 
ATOM   305  O  O   . SER A 1 42  ? 9.29583   -5.82921  33.62809  1.000 13.87958  ? 78  SER A O   1 
ATOM   306  C  CB  . SER A 1 42  ? 10.48674  -4.99913  36.67611  1.000 13.22096  ? 78  SER A CB  1 
ATOM   307  O  OG  . SER A 1 42  ? 10.07011  -4.62018  37.99258  1.000 13.77327  ? 78  SER A OG  1 
ATOM   308  N  N   . ARG A 1 43  ? 11.01303  -7.03642  34.45147  1.000 13.99905  ? 79  ARG A N   1 
ATOM   309  C  CA  . ARG A 1 43  ? 11.45484  -7.40805  33.11243  1.000 14.15627  ? 79  ARG A CA  1 
ATOM   310  C  C   . ARG A 1 43  ? 10.36171  -8.13429  32.34254  1.000 17.29202  ? 79  ARG A C   1 
ATOM   311  O  O   . ARG A 1 43  ? 10.18445  -7.89732  31.13893  1.000 15.36571  ? 79  ARG A O   1 
ATOM   312  C  CB  . ARG A 1 43  ? 12.70481  -8.28704  33.17729  1.000 16.67987  ? 79  ARG A CB  1 
ATOM   313  C  CG  . ARG A 1 43  ? 13.29217  -8.43050  31.77650  1.000 18.39747  ? 79  ARG A CG  1 
ATOM   314  C  CD  . ARG A 1 43  ? 14.52123  -9.29947  31.73910  1.000 17.99164  ? 79  ARG A CD  1 
ATOM   315  N  NE  . ARG A 1 43  ? 15.05508  -9.24786  30.38149  1.000 15.35282  ? 79  ARG A NE  1 
ATOM   316  C  CZ  . ARG A 1 43  ? 15.59607  -10.28223 29.75162  1.000 17.79413  ? 79  ARG A CZ  1 
ATOM   317  N  NH1 . ARG A 1 43  ? 15.74362  -11.45634 30.35050  1.000 17.13149  ? 79  ARG A NH1 1 
ATOM   318  N  NH2 . ARG A 1 43  ? 16.03889  -10.12124 28.50641  1.000 15.37572  ? 79  ARG A NH2 1 
ATOM   319  N  N   . GLU A 1 44  ? 9.63126   -9.03782  33.00360  1.000 15.31632  ? 80  GLU A N   1 
ATOM   320  C  CA  . GLU A 1 44  ? 8.60942   -9.79174  32.27912  1.000 15.07298  ? 80  GLU A CA  1 
ATOM   321  C  C   . GLU A 1 44  ? 7.58043   -8.85761  31.67172  1.000 15.63950  ? 80  GLU A C   1 
ATOM   322  O  O   . GLU A 1 44  ? 7.08575   -9.10787  30.56741  1.000 17.43392  ? 80  GLU A O   1 
ATOM   323  C  CB  . GLU A 1 44  ? 7.91779   -10.80323 33.19082  1.000 16.39026  ? 80  GLU A CB  1 
ATOM   324  C  CG  . GLU A 1 44  ? 8.73779   -12.06256 33.39968  1.000 18.20464  ? 80  GLU A CG  1 
ATOM   325  C  CD  . GLU A 1 44  ? 7.94357   -13.18596 34.05005  1.000 26.40730  ? 80  GLU A CD  1 
ATOM   326  O  OE1 . GLU A 1 44  ? 6.70435   -13.07708 34.12200  1.000 26.55809  ? 80  GLU A OE1 1 
ATOM   327  O  OE2 . GLU A 1 44  ? 8.57444   -14.16559 34.49787  1.000 28.25130  ? 80  GLU A OE2 1 
ATOM   328  N  N   . TYR A 1 45  ? 7.24419   -7.76836  32.37656  1.000 14.00769  ? 81  TYR A N   1 
ATOM   329  C  CA  . TYR A 1 45  ? 6.27720   -6.82897  31.81706  1.000 14.43133  ? 81  TYR A CA  1 
ATOM   330  C  C   . TYR A 1 45  ? 6.83698   -6.20907  30.54258  1.000 16.76111  ? 81  TYR A C   1 
ATOM   331  O  O   . TYR A 1 45  ? 6.15916   -6.15048  29.50858  1.000 15.96470  ? 81  TYR A O   1 
ATOM   332  C  CB  . TYR A 1 45  ? 5.92507   -5.72638  32.82846  1.000 14.46289  ? 81  TYR A CB  1 
ATOM   333  C  CG  . TYR A 1 45  ? 4.97891   -4.72153  32.20200  1.000 15.05432  ? 81  TYR A CG  1 
ATOM   334  C  CD1 . TYR A 1 45  ? 3.60686   -4.91361  32.25836  1.000 16.50797  ? 81  TYR A CD1 1 
ATOM   335  C  CD2 . TYR A 1 45  ? 5.46654   -3.60756  31.51139  1.000 15.08954  ? 81  TYR A CD2 1 
ATOM   336  C  CE1 . TYR A 1 45  ? 2.73869   -4.01667  31.65497  1.000 17.22693  ? 81  TYR A CE1 1 
ATOM   337  C  CE2 . TYR A 1 45  ? 4.60587   -2.70689  30.89897  1.000 15.89933  ? 81  TYR A CE2 1 
ATOM   338  C  CZ  . TYR A 1 45  ? 3.24314   -2.91113  30.98947  1.000 19.63482  ? 81  TYR A CZ  1 
ATOM   339  O  OH  . TYR A 1 45  ? 2.38415   -2.01549  30.37888  1.000 21.36527  ? 81  TYR A OH  1 
ATOM   340  N  N   . CYS A 1 46  ? 8.08027   -5.71564  30.61758  1.000 14.70193  ? 82  CYS A N   1 
ATOM   341  C  CA  . CYS A 1 46  ? 8.70578   -5.09220  29.46278  1.000 14.65442  ? 82  CYS A CA  1 
ATOM   342  C  C   . CYS A 1 46  ? 8.74756   -6.05616  28.28300  1.000 15.31858  ? 82  CYS A C   1 
ATOM   343  O  O   . CYS A 1 46  ? 8.51504   -5.65123  27.13441  1.000 17.06042  ? 82  CYS A O   1 
ATOM   344  C  CB  . CYS A 1 46  ? 10.12315  -4.64922  29.82115  1.000 14.77233  ? 82  CYS A CB  1 
ATOM   345  S  SG  . CYS A 1 46  ? 10.19362  -3.40033  31.12444  1.000 16.45393  ? 82  CYS A SG  1 
ATOM   346  N  N   . LEU A 1 47  ? 9.09473   -7.33152  28.55086  1.000 14.68136  ? 83  LEU A N   1 
ATOM   347  C  CA  . LEU A 1 47  ? 9.14518   -8.34429  27.49430  1.000 15.02711  ? 83  LEU A CA  1 
ATOM   348  C  C   . LEU A 1 47  ? 7.76627   -8.57518  26.89050  1.000 15.58339  ? 83  LEU A C   1 
ATOM   349  O  O   . LEU A 1 47  ? 7.62415   -8.67196  25.66423  1.000 20.10802  ? 83  LEU A O   1 
ATOM   350  C  CB  . LEU A 1 47  ? 9.70029   -9.66656  28.05095  1.000 15.18059  ? 83  LEU A CB  1 
ATOM   351  C  CG  . LEU A 1 47  ? 11.17151  -9.61743  28.47817  1.000 16.39617  ? 83  LEU A CG  1 
ATOM   352  C  CD1 . LEU A 1 47  ? 11.61468  -10.92294 29.18633  1.000 16.98439  ? 83  LEU A CD1 1 
ATOM   353  C  CD2 . LEU A 1 47  ? 12.03716  -9.35240  27.23051  1.000 18.70731  ? 83  LEU A CD2 1 
ATOM   354  N  N   . GLN A 1 48  ? 6.73459   -8.64050  27.73967  1.000 16.01189  ? 84  GLN A N   1 
ATOM   355  C  CA  . GLN A 1 48  ? 5.37503   -8.83746  27.24070  1.000 19.88264  ? 84  GLN A CA  1 
ATOM   356  C  C   . GLN A 1 48  ? 4.94876   -7.70183  26.31379  1.000 19.18664  ? 84  GLN A C   1 
ATOM   357  O  O   . GLN A 1 48  ? 4.15667   -7.91563  25.38390  1.000 19.76242  ? 84  GLN A O   1 
ATOM   358  C  CB  . GLN A 1 48  ? 4.42854   -9.01102  28.44288  1.000 21.36289  ? 84  GLN A CB  1 
ATOM   359  C  CG  . GLN A 1 48  ? 2.96304   -8.60400  28.26400  1.000 35.79268  ? 84  GLN A CG  1 
ATOM   360  C  CD  . GLN A 1 48  ? 2.36206   -8.06334  29.57061  1.000 44.45589  ? 84  GLN A CD  1 
ATOM   361  O  OE1 . GLN A 1 48  ? 2.60356   -8.62492  30.65255  1.000 37.04763  ? 84  GLN A OE1 1 
ATOM   362  N  NE2 . GLN A 1 48  ? 1.59782   -6.96675  29.48149  1.000 33.65278  ? 84  GLN A NE2 1 
ATOM   363  N  N   . GLU A 1 49  ? 5.48731   -6.50366  26.52434  1.000 16.42581  ? 85  GLU A N   1 
ATOM   364  C  CA  . GLU A 1 49  ? 5.13922   -5.34017  25.72580  1.000 18.56748  ? 85  GLU A CA  1 
ATOM   365  C  C   . GLU A 1 49  ? 6.05639   -5.16258  24.53174  1.000 20.03475  ? 85  GLU A C   1 
ATOM   366  O  O   . GLU A 1 49  ? 6.02937   -4.10461  23.88914  1.000 23.95252  ? 85  GLU A O   1 
ATOM   367  C  CB  . GLU A 1 49  ? 5.16031   -4.07314  26.60180  1.000 17.85723  ? 85  GLU A CB  1 
ATOM   368  C  CG  . GLU A 1 49  ? 4.04761   -4.08119  27.65041  1.000 22.58375  ? 85  GLU A CG  1 
ATOM   369  C  CD  . GLU A 1 49  ? 2.64382   -4.22909  27.05868  1.000 28.24589  ? 85  GLU A CD  1 
ATOM   370  O  OE1 . GLU A 1 49  ? 2.28429   -3.45913  26.14236  1.000 30.18005  ? 85  GLU A OE1 1 
ATOM   371  O  OE2 . GLU A 1 49  ? 1.89279   -5.11852  27.51688  1.000 26.64244  ? 85  GLU A OE2 1 
ATOM   372  N  N   . GLY A 1 50  ? 6.86368   -6.16395  24.20761  1.000 17.71800  ? 86  GLY A N   1 
ATOM   373  C  CA  . GLY A 1 50  ? 7.74715   -6.01444  23.05664  1.000 16.61370  ? 86  GLY A CA  1 
ATOM   374  C  C   . GLY A 1 50  ? 8.93022   -5.10680  23.31493  1.000 17.28203  ? 86  GLY A C   1 
ATOM   375  O  O   . GLY A 1 50  ? 9.33483   -4.33267  22.43102  1.000 19.69379  ? 86  GLY A O   1 
ATOM   376  N  N   . ALA A 1 51  ? 9.49468   -5.16556  24.51652  1.000 15.21372  ? 87  ALA A N   1 
ATOM   377  C  CA  . ALA A 1 51  ? 10.59396  -4.27988  24.86237  1.000 14.28109  ? 87  ALA A CA  1 
ATOM   378  C  C   . ALA A 1 51  ? 11.49497  -5.01653  25.83612  1.000 16.44963  ? 87  ALA A C   1 
ATOM   379  O  O   . ALA A 1 51  ? 11.51029  -6.25203  25.85058  1.000 16.43436  ? 87  ALA A O   1 
ATOM   380  C  CB  . ALA A 1 51  ? 10.04682  -2.97291  25.45169  1.000 14.89843  ? 87  ALA A CB  1 
ATOM   381  N  N   . ASP A 1 52  ? 12.23088  -4.28304  26.65955  1.000 13.95112  ? 88  ASP A N   1 
ATOM   382  C  CA  . ASP A 1 52  ? 12.99720  -4.89197  27.74147  1.000 14.12604  ? 88  ASP A CA  1 
ATOM   383  C  C   . ASP A 1 52  ? 13.24378  -3.77744  28.75025  1.000 13.71739  ? 88  ASP A C   1 
ATOM   384  O  O   . ASP A 1 52  ? 12.82253  -2.63661  28.54690  1.000 14.38395  ? 88  ASP A O   1 
ATOM   385  C  CB  . ASP A 1 52  ? 14.31610  -5.48962  27.21622  1.000 13.89304  ? 88  ASP A CB  1 
ATOM   386  C  CG  . ASP A 1 52  ? 14.77054  -6.72103  27.99164  1.000 16.11592  ? 88  ASP A CG  1 
ATOM   387  O  OD1 . ASP A 1 52  ? 14.56774  -6.75668  29.22161  1.000 16.54416  ? 88  ASP A OD1 1 
ATOM   388  O  OD2 . ASP A 1 52  ? 15.35974  -7.64831  27.36225  1.000 18.06516  ? 88  ASP A OD2 1 
ATOM   389  N  N   . LEU A 1 53  ? 13.89810  -4.11163  29.85784  1.000 14.50807  ? 89  LEU A N   1 
ATOM   390  C  CA  . LEU A 1 53  ? 14.28159  -3.06945  30.79695  1.000 14.50576  ? 89  LEU A CA  1 
ATOM   391  C  C   . LEU A 1 53  ? 15.27515  -2.11219  30.13606  1.000 16.01323  ? 89  LEU A C   1 
ATOM   392  O  O   . LEU A 1 53  ? 15.96706  -2.46642  29.17002  1.000 15.05962  ? 89  LEU A O   1 
ATOM   393  C  CB  . LEU A 1 53  ? 14.88893  -3.70420  32.05805  1.000 12.66693  ? 89  LEU A CB  1 
ATOM   394  C  CG  . LEU A 1 53  ? 13.88019  -4.35601  33.01060  1.000 15.32392  ? 89  LEU A CG  1 
ATOM   395  C  CD1 . LEU A 1 53  ? 14.63830  -5.08181  34.10189  1.000 14.39840  ? 89  LEU A CD1 1 
ATOM   396  C  CD2 . LEU A 1 53  ? 12.96310  -3.30405  33.67128  1.000 16.19030  ? 89  LEU A CD2 1 
ATOM   397  N  N   . ALA A 1 54  ? 15.29366  -0.86483  30.62481  1.000 14.02878  ? 90  ALA A N   1 
ATOM   398  C  CA  . ALA A 1 54  ? 16.07324  0.18616   29.96854  1.000 14.74824  ? 90  ALA A CA  1 
ATOM   399  C  C   . ALA A 1 54  ? 17.55735  -0.16555  29.95153  1.000 15.88185  ? 90  ALA A C   1 
ATOM   400  O  O   . ALA A 1 54  ? 18.10651  -0.67579  30.93169  1.000 15.44625  ? 90  ALA A O   1 
ATOM   401  C  CB  . ALA A 1 54  ? 15.85243  1.52676   30.68287  1.000 14.15029  ? 90  ALA A CB  1 
ATOM   402  N  N   . ILE A 1 55  ? 18.20561  0.12182   28.82686  1.000 14.14877  ? 91  ILE A N   1 
ATOM   403  C  CA  . ILE A 1 55  ? 19.65042  -0.04729  28.67156  1.000 14.15582  ? 91  ILE A CA  1 
ATOM   404  C  C   . ILE A 1 55  ? 20.27832  1.33421   28.50253  1.000 13.80109  ? 91  ILE A C   1 
ATOM   405  O  O   . ILE A 1 55  ? 19.88342  2.10768   27.61458  1.000 14.96305  ? 91  ILE A O   1 
ATOM   406  C  CB  . ILE A 1 55  ? 19.97033  -0.94325  27.47477  1.000 14.56473  ? 91  ILE A CB  1 
ATOM   407  C  CG1 . ILE A 1 55  ? 19.47211  -2.36239  27.72134  1.000 16.96928  ? 91  ILE A CG1 1 
ATOM   408  C  CG2 . ILE A 1 55  ? 21.48857  -0.94801  27.19805  1.000 14.77551  ? 91  ILE A CG2 1 
ATOM   409  C  CD1 . ILE A 1 55  ? 19.37870  -3.17682  26.41499  1.000 19.52373  ? 91  ILE A CD1 1 
ATOM   410  N  N   . ILE A 1 56  ? 21.23594  1.66378   29.36662  1.000 15.09000  ? 92  ILE A N   1 
ATOM   411  C  CA  . ILE A 1 56  ? 21.84225  2.99220   29.36009  1.000 15.64312  ? 92  ILE A CA  1 
ATOM   412  C  C   . ILE A 1 56  ? 23.06896  2.97016   28.45325  1.000 17.12524  ? 92  ILE A C   1 
ATOM   413  O  O   . ILE A 1 56  ? 24.07202  2.31488   28.76090  1.000 22.04189  ? 92  ILE A O   1 
ATOM   414  C  CB  . ILE A 1 56  ? 22.20568  3.45372   30.77038  1.000 17.82497  ? 92  ILE A CB  1 
ATOM   415  C  CG1 . ILE A 1 56  ? 20.97562  3.35259   31.68252  1.000 20.63835  ? 92  ILE A CG1 1 
ATOM   416  C  CG2 . ILE A 1 56  ? 22.78619  4.89714   30.70517  1.000 19.80228  ? 92  ILE A CG2 1 
ATOM   417  C  CD1 . ILE A 1 56  ? 19.75762  4.09296   31.13409  1.000 19.33899  ? 92  ILE A CD1 1 
ATOM   418  N  N   . ASN A 1 57  ? 22.98609  3.70636   27.33864  1.000 16.87067  ? 93  ASN A N   1 
ATOM   419  C  CA  . ASN A 1 57  ? 23.99550  3.68403   26.28248  1.000 19.41116  ? 93  ASN A CA  1 
ATOM   420  C  C   . ASN A 1 57  ? 24.80045  4.96645   26.15491  1.000 23.63667  ? 93  ASN A C   1 
ATOM   421  O  O   . ASN A 1 57  ? 25.73082  5.00238   25.33911  1.000 25.56138  ? 93  ASN A O   1 
ATOM   422  C  CB  . ASN A 1 57  ? 23.33880  3.41499   24.92376  1.000 22.69588  ? 93  ASN A CB  1 
ATOM   423  C  CG  . ASN A 1 57  ? 22.61758  2.10044   24.89673  1.000 24.73913  ? 93  ASN A CG  1 
ATOM   424  O  OD1 . ASN A 1 57  ? 21.39738  2.03980   25.07419  1.000 19.72644  ? 93  ASN A OD1 1 
ATOM   425  N  ND2 . ASN A 1 57  ? 23.36838  1.02890   24.68976  1.000 21.14121  ? 93  ASN A ND2 1 
ATOM   426  N  N   . SER A 1 58  ? 24.45993  6.01940   26.89777  1.000 21.39199  ? 94  SER A N   1 
ATOM   427  C  CA  . SER A 1 58  ? 25.13488  7.30195   26.73082  1.000 20.42636  ? 94  SER A CA  1 
ATOM   428  C  C   . SER A 1 58  ? 24.96111  8.14355   27.98405  1.000 26.60890  ? 94  SER A C   1 
ATOM   429  O  O   . SER A 1 58  ? 24.06564  7.90745   28.80270  1.000 21.63348  ? 94  SER A O   1 
ATOM   430  C  CB  . SER A 1 58  ? 24.60899  8.06271   25.50081  1.000 22.95743  ? 94  SER A CB  1 
ATOM   431  O  OG  . SER A 1 58  ? 23.28469  8.54374   25.69765  1.000 23.93200  ? 94  SER A OG  1 
ATOM   432  N  N   . ARG A 1 59  ? 25.83077  9.14380   28.12574  1.000 19.88058  ? 95  ARG A N   1 
ATOM   433  C  CA  . ARG A 1 59  ? 25.66940  10.04961  29.25774  1.000 20.29003  ? 95  ARG A CA  1 
ATOM   434  C  C   . ARG A 1 59  ? 24.33800  10.77776  29.18283  1.000 18.38030  ? 95  ARG A C   1 
ATOM   435  O  O   . ARG A 1 59  ? 23.69342  11.01649  30.20822  1.000 20.86650  ? 95  ARG A O   1 
ATOM   436  C  CB  . ARG A 1 59  ? 26.80355  11.07600  29.30799  1.000 21.96200  ? 95  ARG A CB  1 
ATOM   437  C  CG  . ARG A 1 59  ? 26.85322  11.83248  30.62227  1.000 33.19877  ? 95  ARG A CG  1 
ATOM   438  C  CD  . ARG A 1 59  ? 27.91757  12.93155  30.58079  1.000 43.24237  ? 95  ARG A CD  1 
ATOM   439  N  NE  . ARG A 1 59  ? 29.27027  12.38740  30.57984  1.000 46.13189  ? 95  ARG A NE  1 
ATOM   440  C  CZ  . ARG A 1 59  ? 29.84095  11.77790  31.61145  1.000 61.22615  ? 95  ARG A CZ  1 
ATOM   441  N  NH1 . ARG A 1 59  ? 29.22369  11.66398  32.77795  1.000 59.50459  ? 95  ARG A NH1 1 
ATOM   442  N  NH2 . ARG A 1 59  ? 31.06529  11.27548  31.47139  1.000 58.93580  ? 95  ARG A NH2 1 
ATOM   443  N  N   . ALA A 1 60  ? 23.92577  11.16070  27.97787  1.000 20.76704  ? 96  ALA A N   1 
ATOM   444  C  CA  . ALA A 1 60  ? 22.65034  11.84743  27.82413  1.000 20.26647  ? 96  ALA A CA  1 
ATOM   445  C  C   . ALA A 1 60  ? 21.49785  10.97053  28.29026  1.000 19.36847  ? 96  ALA A C   1 
ATOM   446  O  O   . ALA A 1 60  ? 20.52749  11.46655  28.87071  1.000 17.94105  ? 96  ALA A O   1 
ATOM   447  C  CB  . ALA A 1 60  ? 22.44865  12.23806  26.35862  1.000 19.04892  ? 96  ALA A CB  1 
ATOM   448  N  N   . GLU A 1 61  ? 21.57271  9.66740   28.00555  1.000 17.72925  ? 97  GLU A N   1 
ATOM   449  C  CA  . GLU A 1 61  ? 20.49400  8.77149   28.41692  1.000 16.79809  ? 97  GLU A CA  1 
ATOM   450  C  C   . GLU A 1 61  ? 20.50574  8.56494   29.92721  1.000 17.96780  ? 97  GLU A C   1 
ATOM   451  O  O   . GLU A 1 61  ? 19.44218  8.47397   30.56340  1.000 17.46184  ? 97  GLU A O   1 
ATOM   452  C  CB  . GLU A 1 61  ? 20.59908  7.43682   27.68227  1.000 19.91114  ? 97  GLU A CB  1 
ATOM   453  C  CG  . GLU A 1 61  ? 19.34465  6.56172   27.85447  1.000 16.86972  ? 97  GLU A CG  1 
ATOM   454  C  CD  . GLU A 1 61  ? 19.41653  5.31298   27.01769  1.000 14.25648  ? 97  GLU A CD  1 
ATOM   455  O  OE1 . GLU A 1 61  ? 20.54830  4.96443   26.56973  1.000 17.75208  ? 97  GLU A OE1 1 
ATOM   456  O  OE2 . GLU A 1 61  ? 18.35087  4.67035   26.81320  1.000 15.98496  ? 97  GLU A OE2 1 
ATOM   457  N  N   . GLN A 1 62  ? 21.69471  8.51950   30.52984  1.000 17.13298  ? 98  GLN A N   1 
ATOM   458  C  CA  . GLN A 1 62  ? 21.75978  8.47765   31.98678  1.000 15.66596  ? 98  GLN A CA  1 
ATOM   459  C  C   . GLN A 1 62  ? 21.17129  9.74792   32.61242  1.000 19.77711  ? 98  GLN A C   1 
ATOM   460  O  O   . GLN A 1 62  ? 20.44687  9.68102   33.61807  1.000 16.70171  ? 98  GLN A O   1 
ATOM   461  C  CB  . GLN A 1 62  ? 23.20609  8.26427   32.43887  1.000 15.41047  ? 98  GLN A CB  1 
ATOM   462  C  CG  . GLN A 1 62  ? 23.38164  8.29299   33.95886  1.000 15.95754  ? 98  GLN A CG  1 
ATOM   463  C  CD  . GLN A 1 62  ? 22.70415  7.12300   34.67328  1.000 17.12305  ? 98  GLN A CD  1 
ATOM   464  O  OE1 . GLN A 1 62  ? 22.43697  6.07044   34.06859  1.000 17.51693  ? 98  GLN A OE1 1 
ATOM   465  N  NE2 . GLN A 1 62  ? 22.44030  7.30139   35.97327  1.000 15.86972  ? 98  GLN A NE2 1 
ATOM   466  N  N   . ALA A 1 63  ? 21.48526  10.91630  32.04371  1.000 20.26908  ? 99  ALA A N   1 
ATOM   467  C  CA  . ALA A 1 63  ? 20.93276  12.16527  32.56466  1.000 19.85287  ? 99  ALA A CA  1 
ATOM   468  C  C   . ALA A 1 63  ? 19.41006  12.18141  32.45464  1.000 20.95433  ? 99  ALA A C   1 
ATOM   469  O  O   . ALA A 1 63  ? 18.71258  12.65001  33.36342  1.000 20.55826  ? 99  ALA A O   1 
ATOM   470  C  CB  . ALA A 1 63  ? 21.54638  13.34664  31.80555  1.000 19.81710  ? 99  ALA A CB  1 
ATOM   471  N  N   . PHE A 1 64  ? 18.88615  11.67596  31.34055  1.000 15.77585  ? 100 PHE A N   1 
ATOM   472  C  CA  . PHE A 1 64  ? 17.44245  11.53879  31.15014  1.000 19.37633  ? 100 PHE A CA  1 
ATOM   473  C  C   . PHE A 1 64  ? 16.83630  10.63975  32.23230  1.000 22.37036  ? 100 PHE A C   1 
ATOM   474  O  O   . PHE A 1 64  ? 15.84378  11.00060  32.88746  1.000 18.46606  ? 100 PHE A O   1 
ATOM   475  C  CB  . PHE A 1 64  ? 17.24471  11.01019  29.71767  1.000 17.53992  ? 100 PHE A CB  1 
ATOM   476  C  CG  . PHE A 1 64  ? 15.90754  10.40404  29.40106  1.000 16.24249  ? 100 PHE A CG  1 
ATOM   477  C  CD1 . PHE A 1 64  ? 14.81611  11.21682  29.11683  1.000 17.70787  ? 100 PHE A CD1 1 
ATOM   478  C  CD2 . PHE A 1 64  ? 15.77543  9.02298   29.26284  1.000 16.47183  ? 100 PHE A CD2 1 
ATOM   479  C  CE1 . PHE A 1 64  ? 13.59953  10.65290  28.73268  1.000 18.39071  ? 100 PHE A CE1 1 
ATOM   480  C  CE2 . PHE A 1 64  ? 14.56048  8.44518   28.90265  1.000 18.84184  ? 100 PHE A CE2 1 
ATOM   481  C  CZ  . PHE A 1 64  ? 13.46850  9.26525   28.62773  1.000 17.11539  ? 100 PHE A CZ  1 
ATOM   482  N  N   . LEU A 1 65  ? 17.46090  9.48166   32.46927  1.000 16.53655  ? 101 LEU A N   1 
ATOM   483  C  CA  . LEU A 1 65  ? 16.99146  8.56575   33.50667  1.000 17.91214  ? 101 LEU A CA  1 
ATOM   484  C  C   . LEU A 1 65  ? 16.99071  9.24745   34.86693  1.000 17.26454  ? 101 LEU A C   1 
ATOM   485  O  O   . LEU A 1 65  ? 16.01451  9.16058   35.62536  1.000 18.42459  ? 101 LEU A O   1 
ATOM   486  C  CB  . LEU A 1 65  ? 17.88872  7.31560   33.53676  1.000 15.55989  ? 101 LEU A CB  1 
ATOM   487  C  CG  . LEU A 1 65  ? 17.74994  6.38102   34.74087  1.000 16.26121  ? 101 LEU A CG  1 
ATOM   488  C  CD1 . LEU A 1 65  ? 16.37952  5.69195   34.68455  1.000 17.37975  ? 101 LEU A CD1 1 
ATOM   489  C  CD2 . LEU A 1 65  ? 18.85988  5.32814   34.70513  1.000 14.40693  ? 101 LEU A CD2 1 
ATOM   490  N  N   . GLU A 1 66  ? 18.08174  9.95063   35.17958  1.000 16.93661  ? 102 GLU A N   1 
ATOM   491  C  CA  . GLU A 1 66  ? 18.26428  10.52928  36.50854  1.000 16.19673  ? 102 GLU A CA  1 
ATOM   492  C  C   . GLU A 1 66  ? 17.27633  11.66079  36.76377  1.000 17.75404  ? 102 GLU A C   1 
ATOM   493  O  O   . GLU A 1 66  ? 16.83759  11.88318  37.90663  1.000 17.07413  ? 102 GLU A O   1 
ATOM   494  C  CB  . GLU A 1 66  ? 19.70776  11.04421  36.61946  1.000 19.53161  ? 102 GLU A CB  1 
ATOM   495  C  CG  . GLU A 1 66  ? 19.96798  12.06983  37.71351  1.000 30.33390  ? 102 GLU A CG  1 
ATOM   496  C  CD  . GLU A 1 66  ? 21.46307  12.28216  37.96295  1.000 37.57916  ? 102 GLU A CD  1 
ATOM   497  O  OE1 . GLU A 1 66  ? 22.28079  11.65049  37.25460  1.000 41.13777  ? 102 GLU A OE1 1 
ATOM   498  O  OE2 . GLU A 1 66  ? 21.80930  13.08610  38.85687  1.000 57.64441  ? 102 GLU A OE2 1 
ATOM   499  N  N   . ASN A 1 67  ? 16.90844  12.38363  35.71180  1.000 16.19059  ? 103 ASN A N   1 
ATOM   500  C  CA  . ASN A 1 67  ? 16.06978  13.55677  35.89355  1.000 17.20514  ? 103 ASN A CA  1 
ATOM   501  C  C   . ASN A 1 67  ? 14.62128  13.19866  36.23040  1.000 18.22221  ? 103 ASN A C   1 
ATOM   502  O  O   . ASN A 1 67  ? 13.85053  14.08887  36.60895  1.000 16.86564  ? 103 ASN A O   1 
ATOM   503  C  CB  . ASN A 1 67  ? 16.14728  14.41936  34.63399  1.000 17.66259  ? 103 ASN A CB  1 
ATOM   504  C  CG  . ASN A 1 67  ? 15.57759  15.81467  34.84287  1.000 19.67012  ? 103 ASN A CG  1 
ATOM   505  O  OD1 . ASN A 1 67  ? 15.85339  16.47564  35.85860  1.000 19.85158  ? 103 ASN A OD1 1 
ATOM   506  N  ND2 . ASN A 1 67  ? 14.76406  16.26291  33.89332  1.000 19.72573  ? 103 ASN A ND2 1 
ATOM   507  N  N   . PHE A 1 68  ? 14.22103  11.92676  36.11099  1.000 15.16168  ? 104 PHE A N   1 
ATOM   508  C  CA  . PHE A 1 68  ? 12.87818  11.58645  36.57134  1.000 13.70434  ? 104 PHE A CA  1 
ATOM   509  C  C   . PHE A 1 68  ? 12.78764  11.50593  38.09404  1.000 14.22410  ? 104 PHE A C   1 
ATOM   510  O  O   . PHE A 1 68  ? 11.68159  11.35265  38.62248  1.000 15.84392  ? 104 PHE A O   1 
ATOM   511  C  CB  . PHE A 1 68  ? 12.42493  10.27613  35.92004  1.000 15.33944  ? 104 PHE A CB  1 
ATOM   512  C  CG  . PHE A 1 68  ? 12.16744  10.42979  34.44271  1.000 13.21855  ? 104 PHE A CG  1 
ATOM   513  C  CD1 . PHE A 1 68  ? 11.21818  11.34098  34.00370  1.000 15.65212  ? 104 PHE A CD1 1 
ATOM   514  C  CD2 . PHE A 1 68  ? 12.92757  9.73093   33.51354  1.000 18.38803  ? 104 PHE A CD2 1 
ATOM   515  C  CE1 . PHE A 1 68  ? 10.99791  11.52219  32.65176  1.000 18.55734  ? 104 PHE A CE1 1 
ATOM   516  C  CE2 . PHE A 1 68  ? 12.70087  9.89938   32.15105  1.000 17.66441  ? 104 PHE A CE2 1 
ATOM   517  C  CZ  . PHE A 1 68  ? 11.74438  10.78710  31.72521  1.000 20.43893  ? 104 PHE A CZ  1 
ATOM   518  N  N   . LYS A 1 69  ? 13.91694  11.61654  38.80298  1.000 13.71035  ? 105 LYS A N   1 
ATOM   519  C  CA  . LYS A 1 69  ? 13.89395  11.73449  40.26118  1.000 15.37767  ? 105 LYS A CA  1 
ATOM   520  C  C   . LYS A 1 69  ? 13.16131  10.55773  40.89616  1.000 16.92311  ? 105 LYS A C   1 
ATOM   521  O  O   . LYS A 1 69  ? 12.38561  10.70830  41.84107  1.000 20.21659  ? 105 LYS A O   1 
ATOM   522  C  CB  . LYS A 1 69  ? 13.26023  13.06868  40.67506  1.000 17.93382  ? 105 LYS A CB  1 
ATOM   523  C  CG  . LYS A 1 69  ? 13.89604  14.24965  39.97078  1.000 22.76105  ? 105 LYS A CG  1 
ATOM   524  C  CD  . LYS A 1 69  ? 13.31475  15.57743  40.46077  1.000 25.03713  ? 105 LYS A CD  1 
ATOM   525  C  CE  . LYS A 1 69  ? 13.05831  16.54172  39.30312  1.000 23.18278  ? 105 LYS A CE  1 
ATOM   526  N  NZ  . LYS A 1 69  ? 14.22830  16.58497  38.37183  1.000 18.32946  ? 105 LYS A NZ  1 
ATOM   527  N  N   . MET A 1 70  ? 13.44115  9.36210   40.39095  1.000 17.00076  ? 106 MET A N   1 
ATOM   528  C  CA  . MET A 1 70  ? 12.65154  8.19059   40.71851  1.000 16.33551  ? 106 MET A CA  1 
ATOM   529  C  C   . MET A 1 70  ? 13.57463  6.98815   40.82160  1.000 15.37269  ? 106 MET A C   1 
ATOM   530  O  O   . MET A 1 70  ? 14.46730  6.81099   39.99029  1.000 15.74141  ? 106 MET A O   1 
ATOM   531  C  CB  . MET A 1 70  ? 11.59513  7.97440   39.62877  1.000 19.69670  ? 106 MET A CB  1 
ATOM   532  C  CG  . MET A 1 70  ? 10.68661  6.82428   39.87247  1.000 22.20066  ? 106 MET A CG  1 
ATOM   533  S  SD  . MET A 1 70  ? 9.54466   6.72491   38.48606  1.000 23.86234  ? 106 MET A SD  1 
ATOM   534  C  CE  . MET A 1 70  ? 8.75310   8.35963   38.49135  1.000 19.85213  ? 106 MET A CE  1 
ATOM   535  N  N   . THR A 1 71  ? 13.38625  6.17282   41.84575  1.000 14.50527  ? 107 THR A N   1 
ATOM   536  C  CA  . THR A 1 71  ? 14.15728  4.93948   41.91886  1.000 13.14522  ? 107 THR A CA  1 
ATOM   537  C  C   . THR A 1 71  ? 13.55773  3.91708   40.96056  1.000 15.32287  ? 107 THR A C   1 
ATOM   538  O  O   . THR A 1 71  ? 12.36370  3.60412   41.04918  1.000 14.92194  ? 107 THR A O   1 
ATOM   539  C  CB  . THR A 1 71  ? 14.14201  4.41468   43.34521  1.000 17.20642  ? 107 THR A CB  1 
ATOM   540  O  OG1 . THR A 1 71  ? 14.79217  5.39480   44.16160  1.000 17.82255  ? 107 THR A OG1 1 
ATOM   541  C  CG2 . THR A 1 71  ? 14.91479  3.07579   43.42135  1.000 15.57100  ? 107 THR A CG2 1 
ATOM   542  N  N   . LEU A 1 72  ? 14.38907  3.37822   40.06271  1.000 11.25757  ? 108 LEU A N   1 
ATOM   543  C  CA  . LEU A 1 72  ? 13.88862  2.54307   38.97523  1.000 11.70519  ? 108 LEU A CA  1 
ATOM   544  C  C   . LEU A 1 72  ? 14.79268  1.34611   38.73975  1.000 12.93700  ? 108 LEU A C   1 
ATOM   545  O  O   . LEU A 1 72  ? 16.00079  1.50861   38.63088  1.000 13.37111  ? 108 LEU A O   1 
ATOM   546  C  CB  . LEU A 1 72  ? 13.84416  3.31895   37.66540  1.000 13.61150  ? 108 LEU A CB  1 
ATOM   547  C  CG  . LEU A 1 72  ? 12.72138  4.36015   37.56816  1.000 12.19704  ? 108 LEU A CG  1 
ATOM   548  C  CD1 . LEU A 1 72  ? 13.13755  5.41808   36.54284  1.000 14.69856  ? 108 LEU A CD1 1 
ATOM   549  C  CD2 . LEU A 1 72  ? 11.42121  3.66474   37.18335  1.000 14.74934  ? 108 LEU A CD2 1 
ATOM   550  N  N   . TRP A 1 73  ? 14.20381  0.16243   38.59254  1.000 13.76746  ? 109 TRP A N   1 
ATOM   551  C  CA  . TRP A 1 73  ? 14.97271  -0.95468  38.04841  1.000 13.03644  ? 109 TRP A CA  1 
ATOM   552  C  C   . TRP A 1 73  ? 15.38309  -0.62838  36.62095  1.000 14.40907  ? 109 TRP A C   1 
ATOM   553  O  O   . TRP A 1 73  ? 14.59128  -0.07722  35.85391  1.000 15.20399  ? 109 TRP A O   1 
ATOM   554  C  CB  . TRP A 1 73  ? 14.12468  -2.21189  37.99789  1.000 14.75210  ? 109 TRP A CB  1 
ATOM   555  C  CG  . TRP A 1 73  ? 13.88596  -2.91917  39.29197  1.000 12.34516  ? 109 TRP A CG  1 
ATOM   556  C  CD1 . TRP A 1 73  ? 12.66347  -3.40115  39.72432  1.000 12.78168  ? 109 TRP A CD1 1 
ATOM   557  C  CD2 . TRP A 1 73  ? 14.86085  -3.40239  40.23655  1.000 15.54050  ? 109 TRP A CD2 1 
ATOM   558  N  NE1 . TRP A 1 73  ? 12.82346  -4.08219  40.89576  1.000 14.30156  ? 109 TRP A NE1 1 
ATOM   559  C  CE2 . TRP A 1 73  ? 14.15213  -4.10975  41.23459  1.000 15.07642  ? 109 TRP A CE2 1 
ATOM   560  C  CE3 . TRP A 1 73  ? 16.25452  -3.29041  40.34762  1.000 14.76919  ? 109 TRP A CE3 1 
ATOM   561  C  CZ2 . TRP A 1 73  ? 14.78905  -4.70395  42.34831  1.000 15.30412  ? 109 TRP A CZ2 1 
ATOM   562  C  CZ3 . TRP A 1 73  ? 16.89901  -3.88537  41.46518  1.000 15.96698  ? 109 TRP A CZ3 1 
ATOM   563  C  CH2 . TRP A 1 73  ? 16.15764  -4.59002  42.43816  1.000 15.14475  ? 109 TRP A CH2 1 
ATOM   564  N  N   . ILE A 1 74  ? 16.60441  -1.00617  36.25207  1.000 13.43141  ? 110 ILE A N   1 
ATOM   565  C  CA  . ILE A 1 74  ? 17.06606  -0.90793  34.87143  1.000 12.04208  ? 110 ILE A CA  1 
ATOM   566  C  C   . ILE A 1 74  ? 17.63207  -2.25410  34.43337  1.000 13.78584  ? 110 ILE A C   1 
ATOM   567  O  O   . ILE A 1 74  ? 17.78933  -3.18676  35.22797  1.000 13.34129  ? 110 ILE A O   1 
ATOM   568  C  CB  . ILE A 1 74  ? 18.11012  0.21434   34.66225  1.000 13.57223  ? 110 ILE A CB  1 
ATOM   569  C  CG1 . ILE A 1 74  ? 19.36237  -0.03186  35.51223  1.000 15.80543  ? 110 ILE A CG1 1 
ATOM   570  C  CG2 . ILE A 1 74  ? 17.46087  1.59724   34.96285  1.000 16.91623  ? 110 ILE A CG2 1 
ATOM   571  C  CD1 . ILE A 1 74  ? 20.48875  1.03141   35.26897  1.000 15.87031  ? 110 ILE A CD1 1 
ATOM   572  N  N   . GLY A 1 75  ? 17.93243  -2.34429  33.13725  1.000 14.62482  ? 111 GLY A N   1 
ATOM   573  C  CA  . GLY A 1 75  ? 18.20352  -3.63649  32.52070  1.000 13.68919  ? 111 GLY A CA  1 
ATOM   574  C  C   . GLY A 1 75  ? 19.62819  -4.14866  32.65610  1.000 13.79716  ? 111 GLY A C   1 
ATOM   575  O  O   . GLY A 1 75  ? 20.18684  -4.64324  31.68084  1.000 14.08156  ? 111 GLY A O   1 
ATOM   576  N  N   . LEU A 1 76  ? 20.20990  -4.07303  33.84935  1.000 13.69608  ? 112 LEU A N   1 
ATOM   577  C  CA  . LEU A 1 76  ? 21.59297  -4.49833  34.07002  1.000 13.93272  ? 112 LEU A CA  1 
ATOM   578  C  C   . LEU A 1 76  ? 21.59412  -5.54566  35.17289  1.000 15.61367  ? 112 LEU A C   1 
ATOM   579  O  O   . LEU A 1 76  ? 20.95129  -5.35195  36.20943  1.000 15.20101  ? 112 LEU A O   1 
ATOM   580  C  CB  . LEU A 1 76  ? 22.47306  -3.28942  34.45016  1.000 15.00872  ? 112 LEU A CB  1 
ATOM   581  C  CG  . LEU A 1 76  ? 23.98086  -3.52517  34.60909  1.000 15.73605  ? 112 LEU A CG  1 
ATOM   582  C  CD1 . LEU A 1 76  ? 24.54664  -4.04423  33.26688  1.000 13.88223  ? 112 LEU A CD1 1 
ATOM   583  C  CD2 . LEU A 1 76  ? 24.68990  -2.22626  35.06801  1.000 15.69564  ? 112 LEU A CD2 1 
ATOM   584  N  N   . MET A 1 77  ? 22.29857  -6.65783  34.95695  1.000 15.19818  ? 113 MET A N   1 
ATOM   585  C  CA  A MET A 1 77  ? 22.29670  -7.76318  35.90831  0.629 14.84781  ? 113 MET A CA  1 
ATOM   586  C  CA  B MET A 1 77  ? 22.30126  -7.73873  35.93039  0.371 14.85659  ? 113 MET A CA  1 
ATOM   587  C  C   . MET A 1 77  ? 23.68733  -8.36211  36.02256  1.000 14.58503  ? 113 MET A C   1 
ATOM   588  O  O   . MET A 1 77  ? 24.42416  -8.44644  35.03716  1.000 15.77294  ? 113 MET A O   1 
ATOM   589  C  CB  A MET A 1 77  ? 21.33078  -8.89407  35.50909  0.629 19.45712  ? 113 MET A CB  1 
ATOM   590  C  CB  B MET A 1 77  ? 21.26010  -8.82060  35.58139  0.371 19.46078  ? 113 MET A CB  1 
ATOM   591  C  CG  A MET A 1 77  ? 21.03176  -9.85173  36.66897  0.629 24.76693  ? 113 MET A CG  1 
ATOM   592  C  CG  B MET A 1 77  ? 20.71227  -9.56903  36.80255  0.371 26.94175  ? 113 MET A CG  1 
ATOM   593  S  SD  A MET A 1 77  ? 19.87936  -11.19613 36.29595  0.629 28.61321  ? 113 MET A SD  1 
ATOM   594  S  SD  B MET A 1 77  ? 19.63695  -10.96236 36.37877  0.371 27.61838  ? 113 MET A SD  1 
ATOM   595  C  CE  A MET A 1 77  ? 20.07442  -12.15458 37.80112  0.629 33.98039  ? 113 MET A CE  1 
ATOM   596  C  CE  B MET A 1 77  ? 20.76941  -11.98499 35.44199  0.371 25.63319  ? 113 MET A CE  1 
ATOM   597  N  N   . GLU A 1 78  ? 24.00890  -8.82881  37.22527  1.000 14.26257  ? 114 GLU A N   1 
ATOM   598  C  CA  . GLU A 1 78  ? 25.29396  -9.46447  37.47082  1.000 15.28514  ? 114 GLU A CA  1 
ATOM   599  C  C   . GLU A 1 78  ? 25.35755  -10.79943 36.74836  1.000 20.03050  ? 114 GLU A C   1 
ATOM   600  O  O   . GLU A 1 78  ? 24.35220  -11.50822 36.60833  1.000 16.98942  ? 114 GLU A O   1 
ATOM   601  C  CB  . GLU A 1 78  ? 25.47686  -9.69459  38.97496  1.000 16.20366  ? 114 GLU A CB  1 
ATOM   602  C  CG  . GLU A 1 78  ? 26.91345  -10.09457 39.38042  1.000 14.84400  ? 114 GLU A CG  1 
ATOM   603  C  CD  . GLU A 1 78  ? 27.09595  -10.15984 40.88830  1.000 18.48486  ? 114 GLU A CD  1 
ATOM   604  O  OE1 . GLU A 1 78  ? 26.12124  -9.90481  41.62852  1.000 17.27632  ? 114 GLU A OE1 1 
ATOM   605  O  OE2 . GLU A 1 78  ? 28.23386  -10.41617 41.33403  1.000 18.09195  ? 114 GLU A OE2 1 
ATOM   606  N  N   . GLN A 1 79  ? 26.56025  -11.14390 36.28885  1.000 17.64486  ? 115 GLN A N   1 
ATOM   607  C  CA  . GLN A 1 79  ? 26.82360  -12.47408 35.74348  1.000 19.02514  ? 115 GLN A CA  1 
ATOM   608  C  C   . GLN A 1 79  ? 27.12552  -13.38321 36.93165  1.000 19.85382  ? 115 GLN A C   1 
ATOM   609  O  O   . GLN A 1 79  ? 28.20520  -13.30788 37.51815  1.000 20.22025  ? 115 GLN A O   1 
ATOM   610  C  CB  . GLN A 1 79  ? 27.99220  -12.40652 34.76357  1.000 20.38552  ? 115 GLN A CB  1 
ATOM   611  C  CG  . GLN A 1 79  ? 27.80310  -11.36708 33.65839  1.000 26.37784  ? 115 GLN A CG  1 
ATOM   612  C  CD  . GLN A 1 79  ? 28.83447  -11.49094 32.55052  1.000 33.70452  ? 115 GLN A CD  1 
ATOM   613  O  OE1 . GLN A 1 79  ? 28.64321  -12.23008 31.58603  1.000 34.19050  ? 115 GLN A OE1 1 
ATOM   614  N  NE2 . GLN A 1 79  ? 29.93343  -10.76397 32.68819  1.000 30.62648  ? 115 GLN A NE2 1 
ATOM   615  N  N   . ARG A 1 80  ? 26.14784  -14.20244 37.32845  1.000 20.83871  ? 116 ARG A N   1 
ATOM   616  C  CA  . ARG A 1 80  ? 26.24769  -15.08691 38.50645  1.000 20.91813  ? 116 ARG A CA  1 
ATOM   617  C  C   . ARG A 1 80  ? 26.69806  -14.25659 39.71102  1.000 21.27213  ? 116 ARG A C   1 
ATOM   618  O  O   . ARG A 1 80  ? 26.03781  -13.26004 40.04032  1.000 22.70579  ? 116 ARG A O   1 
ATOM   619  C  CB  . ARG A 1 80  ? 27.13531  -16.27067 38.13262  1.000 26.39973  ? 116 ARG A CB  1 
ATOM   620  C  CG  . ARG A 1 80  ? 26.66671  -16.91275 36.81172  1.000 26.76830  ? 116 ARG A CG  1 
ATOM   621  C  CD  . ARG A 1 80  ? 27.31354  -18.26021 36.48410  1.000 43.92952  ? 116 ARG A CD  1 
ATOM   622  N  NE  . ARG A 1 80  ? 28.73977  -18.34305 36.78830  1.000 56.62251  ? 116 ARG A NE  1 
ATOM   623  C  CZ  . ARG A 1 80  ? 29.69970  -17.73443 36.10164  1.000 57.90276  ? 116 ARG A CZ  1 
ATOM   624  N  NH1 . ARG A 1 80  ? 29.42391  -16.92895 35.08641  1.000 54.79089  ? 116 ARG A NH1 1 
ATOM   625  N  NH2 . ARG A 1 80  ? 30.97032  -17.94659 36.43648  1.000 58.16770  ? 116 ARG A NH2 1 
ATOM   626  N  N   . SER A 1 81  ? 27.77322  -14.63714 40.41097  1.000 21.97004  ? 117 SER A N   1 
ATOM   627  C  CA  . SER A 1 81  ? 28.29473  -13.85976 41.52608  1.000 22.37241  ? 117 SER A CA  1 
ATOM   628  C  C   . SER A 1 81  ? 29.63989  -13.22223 41.19210  1.000 16.30122  ? 117 SER A C   1 
ATOM   629  O  O   . SER A 1 81  ? 30.37595  -12.82419 42.09799  1.000 20.09801  ? 117 SER A O   1 
ATOM   630  C  CB  . SER A 1 81  ? 28.42200  -14.73740 42.77770  1.000 24.87856  ? 117 SER A CB  1 
ATOM   631  O  OG  . SER A 1 81  ? 27.16671  -15.28421 43.15226  1.000 24.23355  ? 117 SER A OG  1 
ATOM   632  N  N   . GLU A 1 82  ? 29.95954  -13.09808 39.90552  1.000 18.18401  ? 118 GLU A N   1 
ATOM   633  C  CA  . GLU A 1 82  ? 31.29602  -12.70137 39.47055  1.000 18.18748  ? 118 GLU A CA  1 
ATOM   634  C  C   . GLU A 1 82  ? 31.56842  -11.21260 39.57153  1.000 20.26502  ? 118 GLU A C   1 
ATOM   635  O  O   . GLU A 1 82  ? 32.71175  -10.80333 39.31944  1.000 19.81536  ? 118 GLU A O   1 
ATOM   636  C  CB  . GLU A 1 82  ? 31.53005  -13.13561 38.02161  1.000 20.90331  ? 118 GLU A CB  1 
ATOM   637  C  CG  . GLU A 1 82  ? 31.42593  -14.61942 37.87751  1.000 22.90063  ? 118 GLU A CG  1 
ATOM   638  C  CD  . GLU A 1 82  ? 32.56052  -15.26006 38.63994  1.000 29.21387  ? 118 GLU A CD  1 
ATOM   639  O  OE1 . GLU A 1 82  ? 33.72754  -15.07631 38.22361  1.000 33.00790  ? 118 GLU A OE1 1 
ATOM   640  O  OE2 . GLU A 1 82  ? 32.28899  -15.87503 39.69043  1.000 27.82949  ? 118 GLU A OE2 1 
ATOM   641  N  N   . ARG A 1 83  ? 30.56683  -10.39785 39.92635  1.000 17.71794  ? 119 ARG A N   1 
ATOM   642  C  CA  . ARG A 1 83  ? 30.74375  -8.96200  40.03960  1.000 16.31817  ? 119 ARG A CA  1 
ATOM   643  C  C   . ARG A 1 83  ? 31.17445  -8.37535  38.69706  1.000 18.37697  ? 119 ARG A C   1 
ATOM   644  O  O   . ARG A 1 83  ? 31.91760  -7.39600  38.62762  1.000 17.96137  ? 119 ARG A O   1 
ATOM   645  C  CB  . ARG A 1 83  ? 31.73733  -8.60304  41.15253  1.000 18.23332  ? 119 ARG A CB  1 
ATOM   646  C  CG  . ARG A 1 83  ? 31.31477  -9.08729  42.56341  1.000 15.63159  ? 119 ARG A CG  1 
ATOM   647  C  CD  . ARG A 1 83  ? 30.45540  -8.03533  43.28930  1.000 15.56748  ? 119 ARG A CD  1 
ATOM   648  N  NE  . ARG A 1 83  ? 29.04070  -8.09191  42.88897  1.000 16.25958  ? 119 ARG A NE  1 
ATOM   649  C  CZ  . ARG A 1 83  ? 28.11845  -7.25513  43.36149  1.000 16.11778  ? 119 ARG A CZ  1 
ATOM   650  N  NH1 . ARG A 1 83  ? 28.45002  -6.21643  44.11454  1.000 15.36695  ? 119 ARG A NH1 1 
ATOM   651  N  NH2 . ARG A 1 83  ? 26.83295  -7.47969  43.09638  1.000 13.67963  ? 119 ARG A NH2 1 
ATOM   652  N  N   . THR A 1 84  ? 30.72816  -9.00768  37.62437  1.000 15.75533  ? 120 THR A N   1 
ATOM   653  C  CA  . THR A 1 84  ? 30.76713  -8.42758  36.29839  1.000 19.39625  ? 120 THR A CA  1 
ATOM   654  C  C   . THR A 1 84  ? 29.31743  -8.32297  35.86031  1.000 16.05655  ? 120 THR A C   1 
ATOM   655  O  O   . THR A 1 84  ? 28.45089  -9.00405  36.41939  1.000 18.66317  ? 120 THR A O   1 
ATOM   656  C  CB  . THR A 1 84  ? 31.56237  -9.29092  35.32312  1.000 20.17689  ? 120 THR A CB  1 
ATOM   657  O  OG1 . THR A 1 84  ? 30.99065  -10.59861 35.29153  1.000 21.76925  ? 120 THR A OG1 1 
ATOM   658  C  CG2 . THR A 1 84  ? 33.01251  -9.39777  35.83068  1.000 22.25190  ? 120 THR A CG2 1 
ATOM   659  N  N   . TRP A 1 85  ? 29.05289  -7.48466  34.85738  1.000 15.92967  ? 121 TRP A N   1 
ATOM   660  C  CA  . TRP A 1 85  ? 27.68027  -7.05084  34.59659  1.000 16.52490  ? 121 TRP A CA  1 
ATOM   661  C  C   . TRP A 1 85  ? 27.36638  -7.14284  33.11673  1.000 15.73787  ? 121 TRP A C   1 
ATOM   662  O  O   . TRP A 1 85  ? 28.23049  -6.85592  32.28869  1.000 18.38279  ? 121 TRP A O   1 
ATOM   663  C  CB  . TRP A 1 85  ? 27.47550  -5.59841  35.07155  1.000 16.77646  ? 121 TRP A CB  1 
ATOM   664  C  CG  . TRP A 1 85  ? 27.83483  -5.50376  36.49989  1.000 15.20298  ? 121 TRP A CG  1 
ATOM   665  C  CD1 . TRP A 1 85  ? 29.07555  -5.25046  37.01544  1.000 17.01862  ? 121 TRP A CD1 1 
ATOM   666  C  CD2 . TRP A 1 85  ? 26.96047  -5.71658  37.61684  1.000 14.94178  ? 121 TRP A CD2 1 
ATOM   667  N  NE1 . TRP A 1 85  ? 29.02433  -5.28312  38.39192  1.000 17.95628  ? 121 TRP A NE1 1 
ATOM   668  C  CE2 . TRP A 1 85  ? 27.73717  -5.56601  38.78404  1.000 17.19784  ? 121 TRP A CE2 1 
ATOM   669  C  CE3 . TRP A 1 85  ? 25.59056  -6.00262  37.74210  1.000 15.15586  ? 121 TRP A CE3 1 
ATOM   670  C  CZ2 . TRP A 1 85  ? 27.20285  -5.71173  40.06552  1.000 16.05995  ? 121 TRP A CZ2 1 
ATOM   671  C  CZ3 . TRP A 1 85  ? 25.05240  -6.14416  39.01833  1.000 13.41497  ? 121 TRP A CZ3 1 
ATOM   672  C  CH2 . TRP A 1 85  ? 25.85891  -6.01152  40.16951  1.000 16.71510  ? 121 TRP A CH2 1 
ATOM   673  N  N   . ARG A 1 86  ? 26.11534  -7.50475  32.79485  1.000 15.26045  ? 122 ARG A N   1 
ATOM   674  C  CA  . ARG A 1 86  ? 25.67977  -7.59276  31.40575  1.000 14.23302  ? 122 ARG A CA  1 
ATOM   675  C  C   . ARG A 1 86  ? 24.29247  -6.96925  31.26507  1.000 14.94821  ? 122 ARG A C   1 
ATOM   676  O  O   . ARG A 1 86  ? 23.42321  -7.20004  32.10774  1.000 17.05991  ? 122 ARG A O   1 
ATOM   677  C  CB  . ARG A 1 86  ? 25.61214  -9.06213  30.95767  1.000 19.33204  ? 122 ARG A CB  1 
ATOM   678  C  CG  . ARG A 1 86  ? 25.65226  -9.23716  29.46125  1.000 30.40061  ? 122 ARG A CG  1 
ATOM   679  C  CD  . ARG A 1 86  ? 26.05506  -10.67714 29.09671  1.000 38.49048  ? 122 ARG A CD  1 
ATOM   680  N  NE  . ARG A 1 86  ? 27.50091  -10.85537 29.22145  1.000 40.94857  ? 122 ARG A NE  1 
ATOM   681  C  CZ  . ARG A 1 86  ? 28.39349  -10.63774 28.26180  1.000 46.66175  ? 122 ARG A CZ  1 
ATOM   682  N  NH1 . ARG A 1 86  ? 28.04549  -10.13391 27.09109  1.000 37.10736  ? 122 ARG A NH1 1 
ATOM   683  N  NH2 . ARG A 1 86  ? 29.67838  -10.88904 28.50193  1.000 49.72404  ? 122 ARG A NH2 1 
ATOM   684  N  N   . TRP A 1 87  ? 24.07748  -6.21680  30.18510  1.000 16.37143  ? 123 TRP A N   1 
ATOM   685  C  CA  . TRP A 1 87  ? 22.75778  -5.65081  29.90418  1.000 14.64054  ? 123 TRP A CA  1 
ATOM   686  C  C   . TRP A 1 87  ? 21.81294  -6.73756  29.40065  1.000 16.77609  ? 123 TRP A C   1 
ATOM   687  O  O   . TRP A 1 87  ? 22.23314  -7.82426  28.98589  1.000 19.35340  ? 123 TRP A O   1 
ATOM   688  C  CB  . TRP A 1 87  ? 22.85407  -4.51444  28.86924  1.000 16.55578  ? 123 TRP A CB  1 
ATOM   689  C  CG  . TRP A 1 87  ? 23.64533  -3.33110  29.34146  1.000 15.58116  ? 123 TRP A CG  1 
ATOM   690  C  CD1 . TRP A 1 87  ? 24.94769  -3.02391  29.04240  1.000 17.96381  ? 123 TRP A CD1 1 
ATOM   691  C  CD2 . TRP A 1 87  ? 23.18023  -2.30584  30.22702  1.000 17.11405  ? 123 TRP A CD2 1 
ATOM   692  N  NE1 . TRP A 1 87  ? 25.31623  -1.85006  29.68693  1.000 19.31629  ? 123 TRP A NE1 1 
ATOM   693  C  CE2 . TRP A 1 87  ? 24.23994  -1.39603  30.41647  1.000 17.27114  ? 123 TRP A CE2 1 
ATOM   694  C  CE3 . TRP A 1 87  ? 21.95415  -2.06260  30.86495  1.000 16.28360  ? 123 TRP A CE3 1 
ATOM   695  C  CZ2 . TRP A 1 87  ? 24.11609  -0.26758  31.22732  1.000 18.24650  ? 123 TRP A CZ2 1 
ATOM   696  C  CZ3 . TRP A 1 87  ? 21.83238  -0.93601  31.67052  1.000 15.53085  ? 123 TRP A CZ3 1 
ATOM   697  C  CH2 . TRP A 1 87  ? 22.90584  -0.05576  31.84501  1.000 16.24065  ? 123 TRP A CH2 1 
ATOM   698  N  N   . VAL A 1 88  ? 20.50943  -6.44220  29.45763  1.000 14.62441  ? 124 VAL A N   1 
ATOM   699  C  CA  . VAL A 1 88  ? 19.52636  -7.47707  29.14820  1.000 16.29032  ? 124 VAL A CA  1 
ATOM   700  C  C   . VAL A 1 88  ? 19.57848  -7.89360  27.68602  1.000 17.91611  ? 124 VAL A C   1 
ATOM   701  O  O   . VAL A 1 88  ? 19.04009  -8.95200  27.34042  1.000 21.00837  ? 124 VAL A O   1 
ATOM   702  C  CB  . VAL A 1 88  ? 18.09577  -7.01766  29.50472  1.000 14.61936  ? 124 VAL A CB  1 
ATOM   703  C  CG1 . VAL A 1 88  ? 17.85575  -7.15705  30.98900  1.000 15.38915  ? 124 VAL A CG1 1 
ATOM   704  C  CG2 . VAL A 1 88  ? 17.84420  -5.56033  29.03866  1.000 15.51500  ? 124 VAL A CG2 1 
ATOM   705  N  N   . ASP A 1 89  ? 20.19299  -7.09228  26.81742  1.000 21.53546  ? 125 ASP A N   1 
ATOM   706  C  CA  . ASP A 1 89  ? 20.34037  -7.45189  25.41061  1.000 21.09675  ? 125 ASP A CA  1 
ATOM   707  C  C   . ASP A 1 89  ? 21.58706  -8.29219  25.16799  1.000 21.50304  ? 125 ASP A C   1 
ATOM   708  O  O   . ASP A 1 89  ? 21.90946  -8.60031  24.01081  1.000 24.14316  ? 125 ASP A O   1 
ATOM   709  C  CB  . ASP A 1 89  ? 20.35454  -6.19713  24.51194  1.000 21.52457  ? 125 ASP A CB  1 
ATOM   710  C  CG  . ASP A 1 89  ? 21.57823  -5.31041  24.71801  1.000 23.41997  ? 125 ASP A CG  1 
ATOM   711  O  OD1 . ASP A 1 89  ? 22.33763  -5.52002  25.68023  1.000 23.04011  ? 125 ASP A OD1 1 
ATOM   712  O  OD2 . ASP A 1 89  ? 21.75774  -4.35915  23.91800  1.000 28.08792  ? 125 ASP A OD2 1 
ATOM   713  N  N   . GLY A 1 90  ? 22.27412  -8.69151  26.23574  1.000 20.71217  ? 126 GLY A N   1 
ATOM   714  C  CA  . GLY A 1 90  ? 23.47515  -9.49059  26.12586  1.000 24.10401  ? 126 GLY A CA  1 
ATOM   715  C  C   . GLY A 1 90  ? 24.77738  -8.71426  26.03355  1.000 24.67976  ? 126 GLY A C   1 
ATOM   716  O  O   . GLY A 1 90  ? 25.85207  -9.33392  26.09514  1.000 25.96914  ? 126 GLY A O   1 
ATOM   717  N  N   . THR A 1 91  ? 24.73009  -7.38088  25.91594  1.000 23.98034  ? 127 THR A N   1 
ATOM   718  C  CA  . THR A 1 91  ? 25.98499  -6.63506  25.75856  1.000 24.93370  ? 127 THR A CA  1 
ATOM   719  C  C   . THR A 1 91  ? 26.69650  -6.46117  27.10465  1.000 22.51871  ? 127 THR A C   1 
ATOM   720  O  O   . THR A 1 91  ? 26.04924  -6.27564  28.13636  1.000 21.37798  ? 127 THR A O   1 
ATOM   721  C  CB  . THR A 1 91  ? 25.73234  -5.25699  25.12563  1.000 28.65289  ? 127 THR A CB  1 
ATOM   722  O  OG1 . THR A 1 91  ? 24.79630  -4.49998  25.90781  1.000 28.07840  ? 127 THR A OG1 1 
ATOM   723  C  CG2 . THR A 1 91  ? 25.19924  -5.39068  23.69682  1.000 25.69779  ? 127 THR A CG2 1 
ATOM   724  N  N   . PRO A 1 92  ? 28.02770  -6.49433  27.12519  1.000 20.37212  ? 128 PRO A N   1 
ATOM   725  C  CA  . PRO A 1 92  ? 28.74299  -6.32074  28.39484  1.000 19.91227  ? 128 PRO A CA  1 
ATOM   726  C  C   . PRO A 1 92  ? 28.69630  -4.87207  28.84998  1.000 19.98657  ? 128 PRO A C   1 
ATOM   727  O  O   . PRO A 1 92  ? 28.59871  -3.93916  28.04412  1.000 23.62269  ? 128 PRO A O   1 
ATOM   728  C  CB  . PRO A 1 92  ? 30.17812  -6.73632  28.04697  1.000 28.63060  ? 128 PRO A CB  1 
ATOM   729  C  CG  . PRO A 1 92  ? 30.30205  -6.31757  26.59823  1.000 31.30791  ? 128 PRO A CG  1 
ATOM   730  C  CD  . PRO A 1 92  ? 28.95571  -6.67617  25.99046  1.000 27.94119  ? 128 PRO A CD  1 
ATOM   731  N  N   . LEU A 1 93  ? 28.78015  -4.68456  30.16404  1.000 20.24299  ? 129 LEU A N   1 
ATOM   732  C  CA  . LEU A 1 93  ? 28.86465  -3.33658  30.70375  1.000 21.00926  ? 129 LEU A CA  1 
ATOM   733  C  C   . LEU A 1 93  ? 30.16269  -2.68316  30.26000  1.000 25.54786  ? 129 LEU A C   1 
ATOM   734  O  O   . LEU A 1 93  ? 31.23491  -3.28188  30.38850  1.000 21.05818  ? 129 LEU A O   1 
ATOM   735  C  CB  . LEU A 1 93  ? 28.81541  -3.37099  32.22578  1.000 18.13438  ? 129 LEU A CB  1 
ATOM   736  C  CG  . LEU A 1 93  ? 28.99976  -2.00576  32.89784  1.000 19.40299  ? 129 LEU A CG  1 
ATOM   737  C  CD1 . LEU A 1 93  ? 27.83968  -1.05390  32.53756  1.000 20.50122  ? 129 LEU A CD1 1 
ATOM   738  C  CD2 . LEU A 1 93  ? 29.10652  -2.20719  34.40819  1.000 21.45295  ? 129 LEU A CD2 1 
ATOM   739  N  N   . THR A 1 94  ? 30.06079  -1.46249  29.73249  1.000 21.67178  ? 130 THR A N   1 
ATOM   740  C  CA  . THR A 1 94  ? 31.23462  -0.65353  29.43311  1.000 21.64566  ? 130 THR A CA  1 
ATOM   741  C  C   . THR A 1 94  ? 31.15735  0.61840   30.26742  1.000 18.68794  ? 130 THR A C   1 
ATOM   742  O  O   . THR A 1 94  ? 31.56254  0.60519   31.43160  1.000 27.03363  ? 130 THR A O   1 
ATOM   743  C  CB  . THR A 1 94  ? 31.35329  -0.34853  27.93183  1.000 29.25397  ? 130 THR A CB  1 
ATOM   744  O  OG1 . THR A 1 94  ? 30.11831  0.16302   27.41817  1.000 33.32960  ? 130 THR A OG1 1 
ATOM   745  C  CG2 . THR A 1 94  ? 31.69358  -1.62257  27.16886  1.000 24.49908  ? 130 THR A CG2 1 
ATOM   746  N  N   . GLU A 1 95  ? 30.61586  1.70751   29.72042  1.000 20.51604  ? 131 GLU A N   1 
ATOM   747  C  CA  . GLU A 1 95  ? 30.52167  2.93813   30.49518  1.000 21.44911  ? 131 GLU A CA  1 
ATOM   748  C  C   . GLU A 1 95  ? 29.47576  2.77196   31.59541  1.000 22.38075  ? 131 GLU A C   1 
ATOM   749  O  O   . GLU A 1 95  ? 28.39120  2.23669   31.35188  1.000 22.54541  ? 131 GLU A O   1 
ATOM   750  C  CB  . GLU A 1 95  ? 30.19843  4.12929   29.58679  1.000 29.64400  ? 131 GLU A CB  1 
ATOM   751  C  CG  . GLU A 1 95  ? 31.32345  4.43819   28.57471  1.000 36.23957  ? 131 GLU A CG  1 
ATOM   752  C  CD  . GLU A 1 95  ? 30.87880  5.28082   27.37608  1.000 55.66155  ? 131 GLU A CD  1 
ATOM   753  O  OE1 . GLU A 1 95  ? 29.66921  5.58180   27.25144  1.000 54.40308  ? 131 GLU A OE1 1 
ATOM   754  O  OE2 . GLU A 1 95  ? 31.75587  5.66627   26.56590  1.000 51.67599  ? 131 GLU A OE2 1 
ATOM   755  N  N   . SER A 1 96  ? 29.82095  3.19156   32.81247  1.000 21.93822  ? 132 SER A N   1 
ATOM   756  C  CA  . SER A 1 96  ? 29.00063  2.93884   33.99219  1.000 20.79855  ? 132 SER A CA  1 
ATOM   757  C  C   . SER A 1 96  ? 28.73662  4.22738   34.76952  1.000 21.69219  ? 132 SER A C   1 
ATOM   758  O  O   . SER A 1 96  ? 29.45638  5.22782   34.63962  1.000 19.36741  ? 132 SER A O   1 
ATOM   759  C  CB  . SER A 1 96  ? 29.67352  1.89171   34.90368  1.000 24.67303  ? 132 SER A CB  1 
ATOM   760  O  OG  . SER A 1 96  ? 30.89025  2.40012   35.44336  1.000 21.05873  ? 132 SER A OG  1 
ATOM   761  N  N   . TYR A 1 97  ? 27.68212  4.19649   35.59037  1.000 18.87080  ? 133 TYR A N   1 
ATOM   762  C  CA  . TYR A 1 97  ? 27.26497  5.36754   36.35970  1.000 17.67432  ? 133 TYR A CA  1 
ATOM   763  C  C   . TYR A 1 97  ? 26.84019  4.94101   37.76189  1.000 18.30969  ? 133 TYR A C   1 
ATOM   764  O  O   . TYR A 1 97  ? 25.81337  5.37741   38.28836  1.000 18.19914  ? 133 TYR A O   1 
ATOM   765  C  CB  . TYR A 1 97  ? 26.13720  6.13520   35.65903  1.000 19.39854  ? 133 TYR A CB  1 
ATOM   766  C  CG  . TYR A 1 97  ? 26.51541  6.57266   34.26852  1.000 17.88672  ? 133 TYR A CG  1 
ATOM   767  C  CD1 . TYR A 1 97  ? 27.26846  7.72903   34.07266  1.000 23.43394  ? 133 TYR A CD1 1 
ATOM   768  C  CD2 . TYR A 1 97  ? 26.15261  5.83075   33.15858  1.000 19.10853  ? 133 TYR A CD2 1 
ATOM   769  C  CE1 . TYR A 1 97  ? 27.64307  8.13332   32.79353  1.000 23.09210  ? 133 TYR A CE1 1 
ATOM   770  C  CE2 . TYR A 1 97  ? 26.52181  6.22562   31.88159  1.000 22.93691  ? 133 TYR A CE2 1 
ATOM   771  C  CZ  . TYR A 1 97  ? 27.26665  7.37815   31.70890  1.000 27.20340  ? 133 TYR A CZ  1 
ATOM   772  O  OH  . TYR A 1 97  ? 27.63564  7.77145   30.43918  1.000 27.40932  ? 133 TYR A OH  1 
ATOM   773  N  N   . TRP A 1 98  ? 27.65503  4.08048   38.37637  1.000 16.71492  ? 134 TRP A N   1 
ATOM   774  C  CA  . TRP A 1 98  ? 27.41591  3.62173   39.74095  1.000 16.02300  ? 134 TRP A CA  1 
ATOM   775  C  C   . TRP A 1 98  ? 27.41398  4.78105   40.72682  1.000 20.12190  ? 134 TRP A C   1 
ATOM   776  O  O   . TRP A 1 98  ? 28.22420  5.70926   40.62684  1.000 19.78683  ? 134 TRP A O   1 
ATOM   777  C  CB  . TRP A 1 98  ? 28.52211  2.64466   40.17447  1.000 15.11042  ? 134 TRP A CB  1 
ATOM   778  C  CG  . TRP A 1 98  ? 28.58794  1.36272   39.39030  1.000 15.82918  ? 134 TRP A CG  1 
ATOM   779  C  CD1 . TRP A 1 98  ? 29.57521  0.98917   38.50449  1.000 17.65918  ? 134 TRP A CD1 1 
ATOM   780  C  CD2 . TRP A 1 98  ? 27.66329  0.27313   39.44780  1.000 15.30785  ? 134 TRP A CD2 1 
ATOM   781  N  NE1 . TRP A 1 98  ? 29.29982  -0.26526  37.99387  1.000 18.69510  ? 134 TRP A NE1 1 
ATOM   782  C  CE2 . TRP A 1 98  ? 28.13731  -0.72757  38.56603  1.000 16.32078  ? 134 TRP A CE2 1 
ATOM   783  C  CE3 . TRP A 1 98  ? 26.47948  0.03751   40.17016  1.000 16.18168  ? 134 TRP A CE3 1 
ATOM   784  C  CZ2 . TRP A 1 98  ? 27.46152  -1.94262  38.36691  1.000 17.75705  ? 134 TRP A CZ2 1 
ATOM   785  C  CZ3 . TRP A 1 98  ? 25.80752  -1.18483  39.97907  1.000 17.25969  ? 134 TRP A CZ3 1 
ATOM   786  C  CH2 . TRP A 1 98  ? 26.30178  -2.15536  39.07947  1.000 17.95937  ? 134 TRP A CH2 1 
ATOM   787  N  N   A SER A 1 99  ? 26.50313  4.73052   41.69680  0.620 17.17165  ? 135 SER A N   1 
ATOM   788  N  N   B SER A 1 99  ? 26.51262  4.70341   41.69892  0.380 17.19042  ? 135 SER A N   1 
ATOM   789  C  CA  A SER A 1 99  ? 26.56482  5.72752   42.75671  0.620 20.11854  ? 135 SER A CA  1 
ATOM   790  C  CA  B SER A 1 99  ? 26.54151  5.63140   42.81537  0.380 20.14671  ? 135 SER A CA  1 
ATOM   791  C  C   A SER A 1 99  ? 27.75864  5.43380   43.66288  0.620 18.74243  ? 135 SER A C   1 
ATOM   792  C  C   B SER A 1 99  ? 27.81612  5.43400   43.63018  0.380 18.72299  ? 135 SER A C   1 
ATOM   793  O  O   A SER A 1 99  ? 28.30695  4.32988   43.67374  0.620 19.45336  ? 135 SER A O   1 
ATOM   794  O  O   B SER A 1 99  ? 28.48211  4.39971   43.54411  0.380 19.63035  ? 135 SER A O   1 
ATOM   795  C  CB  A SER A 1 99  ? 25.27679  5.75949   43.58300  0.620 23.97243  ? 135 SER A CB  1 
ATOM   796  C  CB  B SER A 1 99  ? 25.31993  5.42850   43.70109  0.380 23.84020  ? 135 SER A CB  1 
ATOM   797  O  OG  A SER A 1 99  ? 24.88941  4.47458   44.03310  0.620 26.02730  ? 135 SER A OG  1 
ATOM   798  O  OG  B SER A 1 99  ? 25.02746  6.61931   44.38547  0.380 26.57101  ? 135 SER A OG  1 
ATOM   799  N  N   . LEU A 1 100 ? 28.15745  6.44729   44.43037  1.000 24.42316  ? 136 LEU A N   1 
ATOM   800  C  CA  . LEU A 1 100 ? 29.36026  6.35926   45.25136  1.000 28.82698  ? 136 LEU A CA  1 
ATOM   801  C  C   . LEU A 1 100 ? 29.29817  5.15225   46.18600  1.000 21.36720  ? 136 LEU A C   1 
ATOM   802  O  O   . LEU A 1 100 ? 28.32158  4.96128   46.91509  1.000 24.96330  ? 136 LEU A O   1 
ATOM   803  C  CB  . LEU A 1 100 ? 29.53816  7.65491   46.05284  1.000 33.84573  ? 136 LEU A CB  1 
ATOM   804  C  CG  . LEU A 1 100 ? 30.91832  7.94425   46.65555  1.000 41.53880  ? 136 LEU A CG  1 
ATOM   805  C  CD1 . LEU A 1 100 ? 31.11098  9.44014   46.82914  1.000 45.80486  ? 136 LEU A CD1 1 
ATOM   806  C  CD2 . LEU A 1 100 ? 31.07287  7.25167   47.99962  1.000 44.33184  ? 136 LEU A CD2 1 
ATOM   807  N  N   . GLY A 1 101 ? 30.34293  4.32541   46.14253  1.000 20.77379  ? 137 GLY A N   1 
ATOM   808  C  CA  . GLY A 1 101 ? 30.42640  3.13831   46.96744  1.000 22.66965  ? 137 GLY A CA  1 
ATOM   809  C  C   . GLY A 1 101 ? 29.75786  1.89892   46.39765  1.000 23.54777  ? 137 GLY A C   1 
ATOM   810  O  O   . GLY A 1 101 ? 29.77532  0.84589   47.05776  1.000 23.38202  ? 137 GLY A O   1 
ATOM   811  N  N   . GLU A 1 102 ? 29.16759  1.98346   45.20766  1.000 21.48303  ? 138 GLU A N   1 
ATOM   812  C  CA  . GLU A 1 102 ? 28.48403  0.85704   44.58507  1.000 16.72303  ? 138 GLU A CA  1 
ATOM   813  C  C   . GLU A 1 102 ? 29.26104  0.34718   43.37231  1.000 20.29324  ? 138 GLU A C   1 
ATOM   814  O  O   . GLU A 1 102 ? 30.06312  1.07798   42.77519  1.000 19.26609  ? 138 GLU A O   1 
ATOM   815  C  CB  . GLU A 1 102 ? 27.06123  1.26599   44.14620  1.000 18.84940  ? 138 GLU A CB  1 
ATOM   816  C  CG  . GLU A 1 102 ? 26.19816  1.89680   45.25194  1.000 16.55423  ? 138 GLU A CG  1 
ATOM   817  C  CD  . GLU A 1 102 ? 25.84460  0.94738   46.37762  1.000 18.93022  ? 138 GLU A CD  1 
ATOM   818  O  OE1 . GLU A 1 102 ? 25.95210  -0.28570  46.17399  1.000 17.24939  ? 138 GLU A OE1 1 
ATOM   819  O  OE2 . GLU A 1 102 ? 25.41948  1.43458   47.46657  1.000 20.49184  ? 138 GLU A OE2 1 
ATOM   820  N  N   . PRO A 1 103 ? 29.04651  -0.91824  42.97293  1.000 17.73859  ? 139 PRO A N   1 
ATOM   821  C  CA  . PRO A 1 103 ? 28.17310  -1.92140  43.60239  1.000 14.94557  ? 139 PRO A CA  1 
ATOM   822  C  C   . PRO A 1 103 ? 28.85455  -2.52452  44.81482  1.000 19.30826  ? 139 PRO A C   1 
ATOM   823  O  O   . PRO A 1 103 ? 30.08743  -2.54996  44.85249  1.000 17.84830  ? 139 PRO A O   1 
ATOM   824  C  CB  . PRO A 1 103 ? 27.96635  -2.94643  42.48256  1.000 17.68429  ? 139 PRO A CB  1 
ATOM   825  C  CG  . PRO A 1 103 ? 29.29585  -2.91091  41.71789  1.000 19.14393  ? 139 PRO A CG  1 
ATOM   826  C  CD  . PRO A 1 103 ? 29.73569  -1.45112  41.77934  1.000 16.59680  ? 139 PRO A CD  1 
ATOM   827  N  N   . ASN A 1 104 ? 28.10312  -3.01822  45.80442  1.000 15.88041  ? 140 ASN A N   1 
ATOM   828  C  CA  . ASN A 1 104 ? 28.72358  -3.39728  47.06458  1.000 17.20116  ? 140 ASN A CA  1 
ATOM   829  C  C   . ASN A 1 104 ? 28.23087  -4.67717  47.73779  1.000 16.39180  ? 140 ASN A C   1 
ATOM   830  O  O   . ASN A 1 104 ? 28.78075  -5.00889  48.78728  1.000 18.40789  ? 140 ASN A O   1 
ATOM   831  C  CB  . ASN A 1 104 ? 28.59323  -2.22683  48.06412  1.000 17.38098  ? 140 ASN A CB  1 
ATOM   832  C  CG  . ASN A 1 104 ? 27.14973  -1.98220  48.47779  1.000 18.04594  ? 140 ASN A CG  1 
ATOM   833  O  OD1 . ASN A 1 104 ? 26.22660  -2.62051  47.94668  1.000 15.71798  ? 140 ASN A OD1 1 
ATOM   834  N  ND2 . ASN A 1 104 ? 26.94530  -1.09612  49.45467  1.000 17.68057  ? 140 ASN A ND2 1 
ATOM   835  N  N   . ASN A 1 105 ? 27.25022  -5.42002  47.20489  1.000 16.61779  ? 141 ASN A N   1 
ATOM   836  C  CA  . ASN A 1 105 ? 26.72036  -6.59418  47.93100  1.000 16.57178  ? 141 ASN A CA  1 
ATOM   837  C  C   . ASN A 1 105 ? 26.49990  -6.24315  49.40449  1.000 19.59374  ? 141 ASN A C   1 
ATOM   838  O  O   . ASN A 1 105 ? 27.05072  -6.85755  50.32575  1.000 17.70641  ? 141 ASN A O   1 
ATOM   839  C  CB  . ASN A 1 105 ? 27.63585  -7.82090  47.80882  1.000 16.99262  ? 141 ASN A CB  1 
ATOM   840  C  CG  . ASN A 1 105 ? 27.43379  -8.59590  46.50782  1.000 17.91122  ? 141 ASN A CG  1 
ATOM   841  O  OD1 . ASN A 1 105 ? 26.33097  -8.65380  45.97301  1.000 16.70273  ? 141 ASN A OD1 1 
ATOM   842  N  ND2 . ASN A 1 105 ? 28.51248  -9.18939  45.98933  1.000 14.99360  ? 141 ASN A ND2 1 
ATOM   843  N  N   . TYR A 1 106 ? 25.67289  -5.21864  49.59556  1.000 18.95468  ? 142 TYR A N   1 
ATOM   844  C  CA  . TYR A 1 106 ? 25.51969  -4.55229  50.88336  1.000 18.93905  ? 142 TYR A CA  1 
ATOM   845  C  C   . TYR A 1 106 ? 25.27812  -5.54712  52.01241  1.000 21.39379  ? 142 TYR A C   1 
ATOM   846  O  O   . TYR A 1 106 ? 24.43237  -6.44289  51.90417  1.000 21.32892  ? 142 TYR A O   1 
ATOM   847  C  CB  . TYR A 1 106 ? 24.35309  -3.56586  50.77670  1.000 19.46911  ? 142 TYR A CB  1 
ATOM   848  C  CG  . TYR A 1 106 ? 24.07604  -2.73318  52.01092  1.000 18.32545  ? 142 TYR A CG  1 
ATOM   849  C  CD1 . TYR A 1 106 ? 25.02095  -1.84784  52.50781  1.000 27.73266  ? 142 TYR A CD1 1 
ATOM   850  C  CD2 . TYR A 1 106 ? 22.84549  -2.82805  52.66101  1.000 26.78135  ? 142 TYR A CD2 1 
ATOM   851  C  CE1 . TYR A 1 106 ? 24.74897  -1.07610  53.63388  1.000 32.41423  ? 142 TYR A CE1 1 
ATOM   852  C  CE2 . TYR A 1 106 ? 22.57259  -2.07334  53.78346  1.000 23.88433  ? 142 TYR A CE2 1 
ATOM   853  C  CZ  . TYR A 1 106 ? 23.52146  -1.20421  54.26405  1.000 29.91550  ? 142 TYR A CZ  1 
ATOM   854  O  OH  . TYR A 1 106 ? 23.23483  -0.45136  55.37914  1.000 36.75236  ? 142 TYR A OH  1 
ATOM   855  N  N   . GLU A 1 107 ? 26.05198  -5.39615  53.09370  1.000 21.43259  ? 143 GLU A N   1 
ATOM   856  C  CA  . GLU A 1 107 ? 25.92157  -6.24526  54.28863  1.000 21.97445  ? 143 GLU A CA  1 
ATOM   857  C  C   . GLU A 1 107 ? 26.07009  -7.73254  53.97319  1.000 25.58630  ? 143 GLU A C   1 
ATOM   858  O  O   . GLU A 1 107 ? 25.55099  -8.58630  54.69626  1.000 26.63063  ? 143 GLU A O   1 
ATOM   859  C  CB  . GLU A 1 107 ? 24.59458  -5.97974  55.00563  1.000 23.85308  ? 143 GLU A CB  1 
ATOM   860  C  CG  . GLU A 1 107 ? 24.50048  -4.53977  55.49087  1.000 25.16548  ? 143 GLU A CG  1 
ATOM   861  C  CD  . GLU A 1 107 ? 23.28169  -4.29607  56.35972  1.000 32.94163  ? 143 GLU A CD  1 
ATOM   862  O  OE1 . GLU A 1 107 ? 22.21713  -4.88255  56.06200  1.000 40.41465  ? 143 GLU A OE1 1 
ATOM   863  O  OE2 . GLU A 1 107 ? 23.38249  -3.49512  57.31170  1.000 41.42290  ? 143 GLU A OE2 1 
ATOM   864  N  N   . GLY A 1 108 ? 26.80175  -8.06394  52.90940  1.000 18.88478  ? 144 GLY A N   1 
ATOM   865  C  CA  . GLY A 1 108 ? 27.03876  -9.44292  52.55146  1.000 19.46512  ? 144 GLY A CA  1 
ATOM   866  C  C   . GLY A 1 108 ? 25.90723  -10.13172 51.82385  1.000 22.57903  ? 144 GLY A C   1 
ATOM   867  O  O   . GLY A 1 108 ? 25.99065  -11.33698 51.58505  1.000 24.73234  ? 144 GLY A O   1 
ATOM   868  N  N   . ARG A 1 109 ? 24.84839  -9.42772  51.47315  1.000 25.08962  ? 145 ARG A N   1 
ATOM   869  C  CA  . ARG A 1 109 ? 23.77340  -10.13335 50.80182  1.000 25.72613  ? 145 ARG A CA  1 
ATOM   870  C  C   . ARG A 1 109 ? 23.97392  -10.04053 49.29480  1.000 23.81766  ? 145 ARG A C   1 
ATOM   871  O  O   . ARG A 1 109 ? 24.69924  -9.17941  48.78546  1.000 22.95611  ? 145 ARG A O   1 
ATOM   872  C  CB  . ARG A 1 109 ? 22.42136  -9.57140  51.23283  1.000 32.41160  ? 145 ARG A CB  1 
ATOM   873  C  CG  . ARG A 1 109 ? 22.18212  -8.19305  50.73324  1.000 31.41914  ? 145 ARG A CG  1 
ATOM   874  C  CD  . ARG A 1 109 ? 21.22390  -7.42954  51.61758  1.000 43.11889  ? 145 ARG A CD  1 
ATOM   875  N  NE  . ARG A 1 109 ? 21.11183  -6.07995  51.09079  1.000 42.94271  ? 145 ARG A NE  1 
ATOM   876  C  CZ  . ARG A 1 109 ? 20.13185  -5.23319  51.36367  1.000 47.92680  ? 145 ARG A CZ  1 
ATOM   877  N  NH1 . ARG A 1 109 ? 19.29124  -5.44481  52.36795  1.000 37.36918  ? 145 ARG A NH1 1 
ATOM   878  N  NH2 . ARG A 1 109 ? 20.00746  -4.13674  50.62333  1.000 32.29478  ? 145 ARG A NH2 1 
ATOM   879  N  N   . GLN A 1 110 ? 23.37330  -10.98796 48.59022  1.000 22.42069  ? 146 GLN A N   1 
ATOM   880  C  CA  . GLN A 1 110 ? 23.51954  -11.06483 47.14512  1.000 19.56449  ? 146 GLN A CA  1 
ATOM   881  C  C   . GLN A 1 110 ? 22.70086  -9.98309  46.46407  1.000 24.32988  ? 146 GLN A C   1 
ATOM   882  O  O   . GLN A 1 110 ? 21.46918  -10.05058 46.45463  1.000 26.97319  ? 146 GLN A O   1 
ATOM   883  C  CB  . GLN A 1 110 ? 23.10413  -12.44223 46.65575  1.000 26.30998  ? 146 GLN A CB  1 
ATOM   884  C  CG  . GLN A 1 110 ? 23.50388  -12.63332 45.23837  1.000 35.60610  ? 146 GLN A CG  1 
ATOM   885  C  CD  . GLN A 1 110 ? 24.33432  -13.85837 45.02040  1.000 59.29181  ? 146 GLN A CD  1 
ATOM   886  O  OE1 . GLN A 1 110 ? 23.91756  -14.97460 45.35203  1.000 47.94761  ? 146 GLN A OE1 1 
ATOM   887  N  NE2 . GLN A 1 110 ? 25.54151  -13.65871 44.45745  1.000 28.24777  ? 146 GLN A NE2 1 
ATOM   888  N  N   . GLU A 1 111 ? 23.38131  -9.02252  45.84005  1.000 16.85983  ? 147 GLU A N   1 
ATOM   889  C  CA  . GLU A 1 111 ? 22.71197  -7.91423  45.14958  1.000 15.44933  ? 147 GLU A CA  1 
ATOM   890  C  C   . GLU A 1 111 ? 23.07281  -8.00683  43.67301  1.000 16.92048  ? 147 GLU A C   1 
ATOM   891  O  O   . GLU A 1 111 ? 24.05667  -7.41401  43.21832  1.000 16.71735  ? 147 GLU A O   1 
ATOM   892  C  CB  . GLU A 1 111 ? 23.12672  -6.57122  45.75622  1.000 16.77512  ? 147 GLU A CB  1 
ATOM   893  C  CG  . GLU A 1 111 ? 22.65070  -6.41806  47.19913  1.000 16.60908  ? 147 GLU A CG  1 
ATOM   894  C  CD  . GLU A 1 111 ? 22.79614  -4.99372  47.72473  1.000 21.38930  ? 147 GLU A CD  1 
ATOM   895  O  OE1 . GLU A 1 111 ? 23.86501  -4.37735  47.52470  1.000 19.23676  ? 147 GLU A OE1 1 
ATOM   896  O  OE2 . GLU A 1 111 ? 21.82561  -4.49496  48.33829  1.000 17.20879  ? 147 GLU A OE2 1 
ATOM   897  N  N   . GLN A 1 112 ? 22.26013  -8.75159  42.91711  1.000 14.42531  ? 148 GLN A N   1 
ATOM   898  C  CA  . GLN A 1 112 ? 22.58643  -9.06848  41.53630  1.000 14.44778  ? 148 GLN A CA  1 
ATOM   899  C  C   . GLN A 1 112 ? 21.88696  -8.18622  40.51727  1.000 17.35374  ? 148 GLN A C   1 
ATOM   900  O  O   . GLN A 1 112 ? 22.20418  -8.29867  39.33675  1.000 17.63393  ? 148 GLN A O   1 
ATOM   901  C  CB  . GLN A 1 112 ? 22.24470  -10.53528 41.25051  1.000 15.62667  ? 148 GLN A CB  1 
ATOM   902  C  CG  . GLN A 1 112 ? 23.15992  -11.46091 42.04724  1.000 20.22543  ? 148 GLN A CG  1 
ATOM   903  C  CD  . GLN A 1 112 ? 22.77294  -12.92643 41.94012  1.000 28.15747  ? 148 GLN A CD  1 
ATOM   904  O  OE1 . GLN A 1 112 ? 23.58930  -13.77730 41.58662  1.000 35.78677  ? 148 GLN A OE1 1 
ATOM   905  N  NE2 . GLN A 1 112 ? 21.52867  -13.22285 42.26058  1.000 27.26152  ? 148 GLN A NE2 1 
ATOM   906  N  N   . CYS A 1 113 ? 20.94186  -7.33353  40.92943  1.000 13.98840  ? 149 CYS A N   1 
ATOM   907  C  CA  . CYS A 1 113 ? 20.15574  -6.53827  39.98483  1.000 13.21958  ? 149 CYS A CA  1 
ATOM   908  C  C   . CYS A 1 113 ? 20.41302  -5.04786  40.18852  1.000 14.66226  ? 149 CYS A C   1 
ATOM   909  O  O   . CYS A 1 113 ? 20.76046  -4.61517  41.27989  1.000 17.78485  ? 149 CYS A O   1 
ATOM   910  C  CB  . CYS A 1 113 ? 18.66857  -6.85811  40.14880  1.000 14.61010  ? 149 CYS A CB  1 
ATOM   911  S  SG  . CYS A 1 113 ? 18.26856  -8.53996  39.55945  1.000 17.40946  ? 149 CYS A SG  1 
ATOM   912  N  N   . VAL A 1 114 ? 20.25075  -4.24158  39.13509  1.000 13.81553  ? 150 VAL A N   1 
ATOM   913  C  CA  . VAL A 1 114 ? 20.68201  -2.84781  39.20237  1.000 14.33741  ? 150 VAL A CA  1 
ATOM   914  C  C   . VAL A 1 114 ? 19.46525  -1.92888  39.16361  1.000 15.13211  ? 150 VAL A C   1 
ATOM   915  O  O   . VAL A 1 114 ? 18.60375  -2.05459  38.28288  1.000 15.06830  ? 150 VAL A O   1 
ATOM   916  C  CB  . VAL A 1 114 ? 21.67037  -2.50046  38.07800  1.000 14.13072  ? 150 VAL A CB  1 
ATOM   917  C  CG1 . VAL A 1 114 ? 22.08784  -1.03018  38.19652  1.000 14.91735  ? 150 VAL A CG1 1 
ATOM   918  C  CG2 . VAL A 1 114 ? 22.92759  -3.38620  38.17357  1.000 16.35486  ? 150 VAL A CG2 1 
ATOM   919  N  N   . GLU A 1 115 ? 19.40066  -1.01462  40.12414  1.000 14.52628  ? 151 GLU A N   1 
ATOM   920  C  CA  . GLU A 1 115 ? 18.43352  0.07717   40.11595  1.000 13.38061  ? 151 GLU A CA  1 
ATOM   921  C  C   . GLU A 1 115 ? 19.16048  1.40501   39.93874  1.000 17.42855  ? 151 GLU A C   1 
ATOM   922  O  O   . GLU A 1 115 ? 20.33288  1.55949   40.30383  1.000 17.34098  ? 151 GLU A O   1 
ATOM   923  C  CB  . GLU A 1 115 ? 17.64725  0.13986   41.42913  1.000 13.07735  ? 151 GLU A CB  1 
ATOM   924  C  CG  . GLU A 1 115 ? 18.56291  0.38448   42.65207  1.000 15.94549  ? 151 GLU A CG  1 
ATOM   925  C  CD  . GLU A 1 115 ? 17.83561  0.52926   43.97984  1.000 19.69834  ? 151 GLU A CD  1 
ATOM   926  O  OE1 . GLU A 1 115 ? 16.58502  0.45161   44.01607  1.000 18.37238  ? 151 GLU A OE1 1 
ATOM   927  O  OE2 . GLU A 1 115 ? 18.53772  0.75739   45.00714  1.000 18.50509  ? 151 GLU A OE2 1 
ATOM   928  N  N   . GLN A 1 116 ? 18.43508  2.38251   39.40581  1.000 13.65779  ? 152 GLN A N   1 
ATOM   929  C  CA  . GLN A 1 116 ? 18.85114  3.77207   39.50654  1.000 15.34673  ? 152 GLN A CA  1 
ATOM   930  C  C   . GLN A 1 116 ? 18.28215  4.26889   40.82160  1.000 19.30577  ? 152 GLN A C   1 
ATOM   931  O  O   . GLN A 1 116 ? 17.06574  4.20918   41.02972  1.000 15.36006  ? 152 GLN A O   1 
ATOM   932  C  CB  . GLN A 1 116 ? 18.31655  4.59602   38.33090  1.000 14.00733  ? 152 GLN A CB  1 
ATOM   933  C  CG  . GLN A 1 116 ? 18.37464  6.11652   38.57181  1.000 15.60625  ? 152 GLN A CG  1 
ATOM   934  C  CD  . GLN A 1 116 ? 19.80734  6.65358   38.46645  1.000 20.30781  ? 152 GLN A CD  1 
ATOM   935  O  OE1 . GLN A 1 116 ? 20.70521  5.97469   37.93722  1.000 16.66685  ? 152 GLN A OE1 1 
ATOM   936  N  NE2 . GLN A 1 116 ? 20.02557  7.87417   38.96492  1.000 21.11451  ? 152 GLN A NE2 1 
ATOM   937  N  N   . ILE A 1 117 ? 19.13310  4.71333   41.73515  1.000 16.59150  ? 153 ILE A N   1 
ATOM   938  C  CA  . ILE A 1 117 ? 18.60340  5.11378   43.02540  1.000 21.60174  ? 153 ILE A CA  1 
ATOM   939  C  C   . ILE A 1 117 ? 18.50928  6.63284   43.04421  1.000 25.29579  ? 153 ILE A C   1 
ATOM   940  O  O   . ILE A 1 117 ? 19.34403  7.33315   42.44979  1.000 27.91392  ? 153 ILE A O   1 
ATOM   941  C  CB  . ILE A 1 117 ? 19.44873  4.54026   44.18315  1.000 30.28806  ? 153 ILE A CB  1 
ATOM   942  C  CG1 . ILE A 1 117 ? 18.75252  4.77891   45.52256  1.000 33.77711  ? 153 ILE A CG1 1 
ATOM   943  C  CG2 . ILE A 1 117 ? 20.84031  5.16005   44.21147  1.000 33.13491  ? 153 ILE A CG2 1 
ATOM   944  C  CD1 . ILE A 1 117 ? 19.44053  4.07020   46.69350  1.000 42.82825  ? 153 ILE A CD1 1 
ATOM   945  N  N   . ASP A 1 118 ? 17.44762  7.14697   43.66662  1.000 21.49286  ? 154 ASP A N   1 
ATOM   946  C  CA  . ASP A 1 118 ? 17.26312  8.58826   43.81819  1.000 26.44966  ? 154 ASP A CA  1 
ATOM   947  C  C   . ASP A 1 118 ? 17.05188  8.88771   45.29841  1.000 32.66764  ? 154 ASP A C   1 
ATOM   948  O  O   . ASP A 1 118 ? 15.96151  8.66785   45.83323  1.000 36.36908  ? 154 ASP A O   1 
ATOM   949  C  CB  . ASP A 1 118 ? 16.09367  9.08157   42.98036  1.000 27.30917  ? 154 ASP A CB  1 
ATOM   950  C  CG  . ASP A 1 118 ? 16.05214  10.59429  42.88569  1.000 31.77236  ? 154 ASP A CG  1 
ATOM   951  O  OD1 . ASP A 1 118 ? 16.88936  11.16983  42.15616  1.000 36.66111  ? 154 ASP A OD1 1 
ATOM   952  O  OD2 . ASP A 1 118 ? 15.19235  11.20183  43.55616  1.000 32.81905  ? 154 ASP A OD2 1 
ATOM   953  N  N   . ARG A 1 119 ? 18.10182  9.36677   45.95672  1.000 30.24755  ? 155 ARG A N   1 
ATOM   954  C  CA  . ARG A 1 119 ? 18.03920  9.76378   47.35699  1.000 49.06765  ? 155 ARG A CA  1 
ATOM   955  C  C   . ARG A 1 119 ? 18.81959  11.06565  47.49700  1.000 42.67045  ? 155 ARG A C   1 
ATOM   956  O  O   . ARG A 1 119 ? 19.56735  11.45650  46.59825  1.000 47.01948  ? 155 ARG A O   1 
ATOM   957  C  CB  . ARG A 1 119 ? 18.55906  8.64165   48.27461  1.000 46.94957  ? 155 ARG A CB  1 
ATOM   958  C  CG  . ARG A 1 119 ? 20.01780  8.75641   48.67252  1.000 64.48117  ? 155 ARG A CG  1 
ATOM   959  C  CD  . ARG A 1 119 ? 20.31217  8.04758   49.99515  1.000 72.85895  ? 155 ARG A CD  1 
ATOM   960  N  NE  . ARG A 1 119 ? 20.31952  6.59539   49.84260  1.000 78.02743  ? 155 ARG A NE  1 
ATOM   961  C  CZ  . ARG A 1 119 ? 20.17558  5.72858   50.83704  1.000 84.38110  ? 155 ARG A CZ  1 
ATOM   962  N  NH1 . ARG A 1 119 ? 20.03949  6.12999   52.09157  1.000 82.56409  ? 155 ARG A NH1 1 
ATOM   963  N  NH2 . ARG A 1 119 ? 20.17660  4.42493   50.56643  1.000 78.26780  ? 155 ARG A NH2 1 
ATOM   964  N  N   . GLU A 1 120 ? 18.62812  11.75004  48.62943  1.000 63.53854  ? 156 GLU A N   1 
ATOM   965  C  CA  . GLU A 1 120 ? 19.01085  13.15980  48.72601  1.000 65.55469  ? 156 GLU A CA  1 
ATOM   966  C  C   . GLU A 1 120 ? 20.48576  13.38763  48.40697  1.000 67.52570  ? 156 GLU A C   1 
ATOM   967  O  O   . GLU A 1 120 ? 20.82831  14.29420  47.63859  1.000 75.08180  ? 156 GLU A O   1 
ATOM   968  C  CB  . GLU A 1 120 ? 18.66724  13.70639  50.11047  1.000 72.48665  ? 156 GLU A CB  1 
ATOM   969  C  CG  . GLU A 1 120 ? 18.93744  15.20120  50.26335  1.000 74.50014  ? 156 GLU A CG  1 
ATOM   970  C  CD  . GLU A 1 120 ? 18.38248  16.04217  49.12082  1.000 76.46343  ? 156 GLU A CD  1 
ATOM   971  O  OE1 . GLU A 1 120 ? 17.17674  15.92364  48.80615  1.000 73.59105  ? 156 GLU A OE1 1 
ATOM   972  O  OE2 . GLU A 1 120 ? 19.16051  16.83464  48.54305  1.000 71.84786  ? 156 GLU A OE2 1 
ATOM   973  N  N   . ASP A 1 121 ? 21.37605  12.58454  48.98254  1.000 64.19213  ? 157 ASP A N   1 
ATOM   974  C  CA  . ASP A 1 121 ? 22.80724  12.80372  48.80822  1.000 74.50169  ? 157 ASP A CA  1 
ATOM   975  C  C   . ASP A 1 121 ? 23.45433  11.84528  47.81739  1.000 68.81055  ? 157 ASP A C   1 
ATOM   976  O  O   . ASP A 1 121 ? 24.65816  11.96098  47.56489  1.000 64.71229  ? 157 ASP A O   1 
ATOM   977  C  CB  . ASP A 1 121 ? 23.52874  12.70146  50.15852  1.000 80.10420  ? 157 ASP A CB  1 
ATOM   978  C  CG  . ASP A 1 121 ? 23.51988  14.01066  50.92926  1.000 89.41661  ? 157 ASP A CG  1 
ATOM   979  O  OD1 . ASP A 1 121 ? 23.01909  15.02021  50.38626  1.000 91.49827  ? 157 ASP A OD1 1 
ATOM   980  O  OD2 . ASP A 1 121 ? 24.02201  14.03018  52.07532  1.000 82.21109  ? 157 ASP A OD2 1 
ATOM   981  N  N   . LYS A 1 122 ? 22.68763  10.92781  47.23162  1.000 64.26525  ? 158 LYS A N   1 
ATOM   982  C  CA  . LYS A 1 122 ? 23.24223  9.78660   46.51180  1.000 53.50318  ? 158 LYS A CA  1 
ATOM   983  C  C   . LYS A 1 122 ? 22.38645  9.50916   45.28346  1.000 40.56693  ? 158 LYS A C   1 
ATOM   984  O  O   . LYS A 1 122 ? 21.19599  9.21120   45.41710  1.000 43.66063  ? 158 LYS A O   1 
ATOM   985  C  CB  . LYS A 1 122 ? 23.28206  8.56508   47.43822  1.000 58.38222  ? 158 LYS A CB  1 
ATOM   986  C  CG  . LYS A 1 122 ? 24.16089  7.42505   46.99913  1.000 55.46565  ? 158 LYS A CG  1 
ATOM   987  C  CD  . LYS A 1 122 ? 23.79987  6.14117   47.73918  1.000 57.14243  ? 158 LYS A CD  1 
ATOM   988  C  CE  . LYS A 1 122 ? 24.74240  4.98562   47.39564  1.000 40.91965  ? 158 LYS A CE  1 
ATOM   989  N  NZ  . LYS A 1 122 ? 23.96493  3.72435   47.20030  1.000 46.47113  ? 158 LYS A NZ  1 
ATOM   990  N  N   . LYS A 1 123 ? 22.98269  9.59974   44.09249  1.000 39.58509  ? 159 LYS A N   1 
ATOM   991  C  CA  . LYS A 1 123 ? 22.27430  9.31173   42.85301  1.000 34.21128  ? 159 LYS A CA  1 
ATOM   992  C  C   . LYS A 1 123 ? 23.12614  8.42380   41.95271  1.000 30.64774  ? 159 LYS A C   1 
ATOM   993  O  O   . LYS A 1 123 ? 24.35402  8.51696   41.93755  1.000 29.48866  ? 159 LYS A O   1 
ATOM   994  C  CB  . LYS A 1 123 ? 21.90562  10.60463  42.11163  1.000 35.72358  ? 159 LYS A CB  1 
ATOM   995  C  CG  . LYS A 1 123 ? 20.51780  11.11379  42.46602  1.000 46.30346  ? 159 LYS A CG  1 
ATOM   996  C  CD  . LYS A 1 123 ? 20.38633  12.59667  42.16535  1.000 44.79171  ? 159 LYS A CD  1 
ATOM   997  C  CE  . LYS A 1 123 ? 19.21718  13.19035  42.93321  1.000 49.75654  ? 159 LYS A CE  1 
ATOM   998  N  NZ  . LYS A 1 123 ? 19.67893  13.74776  44.23708  1.000 48.68157  ? 159 LYS A NZ  1 
ATOM   999  N  N   . GLY A 1 124 ? 22.46815  7.56404   41.18995  1.000 23.81931  ? 160 GLY A N   1 
ATOM   1000 C  CA  . GLY A 1 124 ? 23.18446  6.73972   40.23675  1.000 20.56343  ? 160 GLY A CA  1 
ATOM   1001 C  C   . GLY A 1 124 ? 22.83357  5.28551   40.45113  1.000 17.73891  ? 160 GLY A C   1 
ATOM   1002 O  O   . GLY A 1 124 ? 21.88540  4.94715   41.16062  1.000 16.81905  ? 160 GLY A O   1 
ATOM   1003 N  N   . TRP A 1 125 ? 23.60285  4.39089   39.84524  1.000 16.62384  ? 161 TRP A N   1 
ATOM   1004 C  CA  . TRP A 1 125 ? 23.20312  2.98622   39.89998  1.000 16.16508  ? 161 TRP A CA  1 
ATOM   1005 C  C   . TRP A 1 125 ? 23.55326  2.36046   41.24572  1.000 20.24250  ? 161 TRP A C   1 
ATOM   1006 O  O   . TRP A 1 125 ? 24.55809  2.70742   41.88143  1.000 17.58245  ? 161 TRP A O   1 
ATOM   1007 C  CB  . TRP A 1 125 ? 23.87724  2.16217   38.80623  1.000 14.12654  ? 161 TRP A CB  1 
ATOM   1008 C  CG  . TRP A 1 125 ? 23.68464  2.63585   37.41724  1.000 14.68071  ? 161 TRP A CG  1 
ATOM   1009 C  CD1 . TRP A 1 125 ? 22.77723  3.55212   36.95580  1.000 15.66011  ? 161 TRP A CD1 1 
ATOM   1010 C  CD2 . TRP A 1 125 ? 24.42650  2.18715   36.28648  1.000 16.49420  ? 161 TRP A CD2 1 
ATOM   1011 N  NE1 . TRP A 1 125 ? 22.92773  3.70756   35.58557  1.000 15.03310  ? 161 TRP A NE1 1 
ATOM   1012 C  CE2 . TRP A 1 125 ? 23.93290  2.86867   35.15858  1.000 15.67486  ? 161 TRP A CE2 1 
ATOM   1013 C  CE3 . TRP A 1 125 ? 25.46673  1.25234   36.11801  1.000 15.34496  ? 161 TRP A CE3 1 
ATOM   1014 C  CZ2 . TRP A 1 125 ? 24.44973  2.65378   33.88047  1.000 16.68698  ? 161 TRP A CZ2 1 
ATOM   1015 C  CZ3 . TRP A 1 125 ? 25.98884  1.05885   34.85067  1.000 15.82315  ? 161 TRP A CZ3 1 
ATOM   1016 C  CH2 . TRP A 1 125 ? 25.47732  1.74374   33.75163  1.000 16.58899  ? 161 TRP A CH2 1 
ATOM   1017 N  N   . ASN A 1 126 ? 22.73117  1.39389   41.65971  1.000 13.74630  ? 162 ASN A N   1 
ATOM   1018 C  CA  . ASN A 1 126 ? 23.00121  0.62230   42.86301  1.000 16.66720  ? 162 ASN A CA  1 
ATOM   1019 C  C   . ASN A 1 126 ? 22.67888  -0.84220  42.58090  1.000 16.26120  ? 162 ASN A C   1 
ATOM   1020 O  O   . ASN A 1 126 ? 21.65826  -1.14137  41.94738  1.000 16.11218  ? 162 ASN A O   1 
ATOM   1021 C  CB  . ASN A 1 126 ? 22.15923  1.15877   44.03466  1.000 16.28895  ? 162 ASN A CB  1 
ATOM   1022 C  CG  . ASN A 1 126 ? 22.22822  0.26880   45.25093  1.000 14.76636  ? 162 ASN A CG  1 
ATOM   1023 O  OD1 . ASN A 1 126 ? 23.32357  -0.07830  45.70658  1.000 15.34409  ? 162 ASN A OD1 1 
ATOM   1024 N  ND2 . ASN A 1 126 ? 21.06276  -0.10727  45.79396  1.000 15.24050  ? 162 ASN A ND2 1 
ATOM   1025 N  N   . ASP A 1 127 ? 23.55253  -1.75710  43.01606  1.000 13.12705  ? 163 ASP A N   1 
ATOM   1026 C  CA  . ASP A 1 127 ? 23.15484  -3.15903  43.03315  1.000 11.39236  ? 163 ASP A CA  1 
ATOM   1027 C  C   . ASP A 1 127 ? 22.24292  -3.43939  44.22498  1.000 15.48320  ? 163 ASP A C   1 
ATOM   1028 O  O   . ASP A 1 127 ? 22.47308  -2.95497  45.34290  1.000 14.07100  ? 163 ASP A O   1 
ATOM   1029 C  CB  . ASP A 1 127 ? 24.36769  -4.10371  43.04797  1.000 12.60143  ? 163 ASP A CB  1 
ATOM   1030 C  CG  . ASP A 1 127 ? 25.26966  -3.93990  44.26750  1.000 15.14227  ? 163 ASP A CG  1 
ATOM   1031 O  OD1 . ASP A 1 127 ? 25.33399  -2.83547  44.86377  1.000 17.37090  ? 163 ASP A OD1 1 
ATOM   1032 O  OD2 . ASP A 1 127 ? 25.98199  -4.93192  44.58980  1.000 15.65724  ? 163 ASP A OD2 1 
ATOM   1033 N  N   . LEU A 1 128 ? 21.20075  -4.22607  43.97965  1.000 15.18549  ? 164 LEU A N   1 
ATOM   1034 C  CA  . LEU A 1 128 ? 20.18405  -4.47750  44.99598  1.000 12.53127  ? 164 LEU A CA  1 
ATOM   1035 C  C   . LEU A 1 128 ? 19.68251  -5.91101  44.87192  1.000 14.17629  ? 164 LEU A C   1 
ATOM   1036 O  O   . LEU A 1 128 ? 19.75943  -6.52174  43.81090  1.000 14.82634  ? 164 LEU A O   1 
ATOM   1037 C  CB  . LEU A 1 128 ? 19.01493  -3.48273  44.83509  1.000 15.42672  ? 164 LEU A CB  1 
ATOM   1038 C  CG  . LEU A 1 128 ? 17.95119  -3.49942  45.93453  1.000 15.66761  ? 164 LEU A CG  1 
ATOM   1039 C  CD1 . LEU A 1 128 ? 18.55900  -2.94961  47.21056  1.000 19.29131  ? 164 LEU A CD1 1 
ATOM   1040 C  CD2 . LEU A 1 128 ? 16.71285  -2.65287  45.52181  1.000 15.24049  ? 164 LEU A CD2 1 
ATOM   1041 N  N   . VAL A 1 129 ? 19.15615  -6.44711  45.97753  1.000 16.09623  ? 165 VAL A N   1 
ATOM   1042 C  CA  . VAL A 1 129 ? 18.53658  -7.77385  45.94256  1.000 17.07106  ? 165 VAL A CA  1 
ATOM   1043 C  C   . VAL A 1 129 ? 17.43338  -7.81330  44.89053  1.000 17.09256  ? 165 VAL A C   1 
ATOM   1044 O  O   . VAL A 1 129 ? 16.53740  -6.95580  44.88283  1.000 17.27698  ? 165 VAL A O   1 
ATOM   1045 C  CB  . VAL A 1 129 ? 17.98220  -8.12485  47.32617  1.000 19.29353  ? 165 VAL A CB  1 
ATOM   1046 C  CG1 . VAL A 1 129 ? 17.31116  -9.49559  47.28825  1.000 22.81017  ? 165 VAL A CG1 1 
ATOM   1047 C  CG2 . VAL A 1 129 ? 19.10867  -8.06730  48.37962  1.000 20.35361  ? 165 VAL A CG2 1 
ATOM   1048 N  N   . CYS A 1 130 ? 17.47837  -8.83133  44.01243  1.000 17.25136  ? 166 CYS A N   1 
ATOM   1049 C  CA  . CYS A 1 130 ? 16.58395  -8.85519  42.85085  1.000 16.98670  ? 166 CYS A CA  1 
ATOM   1050 C  C   . CYS A 1 130 ? 15.13312  -8.99075  43.25701  1.000 16.89878  ? 166 CYS A C   1 
ATOM   1051 O  O   . CYS A 1 130 ? 14.23353  -8.55520  42.52416  1.000 15.38479  ? 166 CYS A O   1 
ATOM   1052 C  CB  . CYS A 1 130 ? 16.92743  -10.01130 41.91606  1.000 17.76404  ? 166 CYS A CB  1 
ATOM   1053 S  SG  . CYS A 1 130 ? 18.56633  -9.82139  41.14605  1.000 21.22497  ? 166 CYS A SG  1 
ATOM   1054 N  N   . GLU A 1 131 ? 14.89295  -9.63580  44.39032  1.000 15.22060  ? 167 GLU A N   1 
ATOM   1055 C  CA  . GLU A 1 131 ? 13.54159  -9.87973  44.88564  1.000 18.01438  ? 167 GLU A CA  1 
ATOM   1056 C  C   . GLU A 1 131 ? 12.90799  -8.66940  45.55676  1.000 17.81295  ? 167 GLU A C   1 
ATOM   1057 O  O   . GLU A 1 131 ? 11.72034  -8.74222  45.91087  1.000 17.59728  ? 167 GLU A O   1 
ATOM   1058 C  CB  . GLU A 1 131 ? 13.59816  -11.07333 45.84011  1.000 22.11701  ? 167 GLU A CB  1 
ATOM   1059 C  CG  . GLU A 1 131 ? 13.91970  -12.37129 45.09578  1.000 31.68180  ? 167 GLU A CG  1 
ATOM   1060 C  CD  . GLU A 1 131 ? 15.39270  -12.51825 44.69345  1.000 45.18354  ? 167 GLU A CD  1 
ATOM   1061 O  OE1 . GLU A 1 131 ? 16.29902  -12.01312 45.40552  1.000 28.47246  ? 167 GLU A OE1 1 
ATOM   1062 O  OE2 . GLU A 1 131 ? 15.63626  -13.15364 43.63757  1.000 51.69097  ? 167 GLU A OE2 1 
ATOM   1063 N  N   . PHE A 1 132 ? 13.65475  -7.57454  45.73387  1.000 15.01796  ? 168 PHE A N   1 
ATOM   1064 C  CA  . PHE A 1 132 ? 13.07368  -6.34043  46.23931  1.000 15.87268  ? 168 PHE A CA  1 
ATOM   1065 C  C   . PHE A 1 132 ? 12.26032  -5.69544  45.11490  1.000 15.18587  ? 168 PHE A C   1 
ATOM   1066 O  O   . PHE A 1 132 ? 12.41223  -6.04866  43.93995  1.000 17.78654  ? 168 PHE A O   1 
ATOM   1067 C  CB  . PHE A 1 132 ? 14.15651  -5.37638  46.73341  1.000 17.55752  ? 168 PHE A CB  1 
ATOM   1068 C  CG  . PHE A 1 132 ? 14.83016  -5.79764  48.04092  1.000 22.55842  ? 168 PHE A CG  1 
ATOM   1069 C  CD1 . PHE A 1 132 ? 14.50988  -6.99353  48.66449  1.000 25.16549  ? 168 PHE A CD1 1 
ATOM   1070 C  CD2 . PHE A 1 132 ? 15.80039  -4.98232  48.61615  1.000 24.96938  ? 168 PHE A CD2 1 
ATOM   1071 C  CE1 . PHE A 1 132 ? 15.14803  -7.37862  49.85350  1.000 28.80639  ? 168 PHE A CE1 1 
ATOM   1072 C  CE2 . PHE A 1 132 ? 16.44316  -5.35522  49.80958  1.000 28.41091  ? 168 PHE A CE2 1 
ATOM   1073 C  CZ  . PHE A 1 132 ? 16.10625  -6.55020  50.42615  1.000 27.48562  ? 168 PHE A CZ  1 
ATOM   1074 N  N   . SER A 1 133 ? 11.37143  -4.77250  45.48379  1.000 15.81508  ? 169 SER A N   1 
ATOM   1075 C  CA  . SER A 1 133 ? 10.49254  -4.15791  44.49807  1.000 15.59893  ? 169 SER A CA  1 
ATOM   1076 C  C   . SER A 1 133 ? 10.81007  -2.68734  44.25428  1.000 14.49333  ? 169 SER A C   1 
ATOM   1077 O  O   . SER A 1 133 ? 11.13574  -1.93033  45.17197  1.000 18.41869  ? 169 SER A O   1 
ATOM   1078 C  CB  . SER A 1 133 ? 9.02967   -4.30676  44.92789  1.000 16.36275  ? 169 SER A CB  1 
ATOM   1079 O  OG  . SER A 1 133 ? 8.62759   -5.64462  44.65038  1.000 16.10981  ? 169 SER A OG  1 
ATOM   1080 N  N   . ASN A 1 134 ? 10.65338  -2.27899  42.99809  1.000 14.46609  ? 170 ASN A N   1 
ATOM   1081 C  CA  . ASN A 1 134 ? 10.86165  -0.89464  42.59181  1.000 14.02117  ? 170 ASN A CA  1 
ATOM   1082 C  C   . ASN A 1 134 ? 9.92058   -0.62976  41.43652  1.000 14.59349  ? 170 ASN A C   1 
ATOM   1083 O  O   . ASN A 1 134 ? 9.54056   -1.55760  40.72166  1.000 12.39395  ? 170 ASN A O   1 
ATOM   1084 C  CB  . ASN A 1 134 ? 12.27518  -0.64538  42.04176  1.000 17.05969  ? 170 ASN A CB  1 
ATOM   1085 C  CG  . ASN A 1 134 ? 13.29335  -0.40818  43.10409  1.000 17.06731  ? 170 ASN A CG  1 
ATOM   1086 O  OD1 . ASN A 1 134 ? 13.07165  0.34749   44.05194  1.000 16.00244  ? 170 ASN A OD1 1 
ATOM   1087 N  ND2 . ASN A 1 134 ? 14.48306  -0.99501  42.89841  1.000 16.47521  ? 170 ASN A ND2 1 
ATOM   1088 N  N   . PHE A 1 135 ? 9.61109   0.64447   41.20016  1.000 13.01500  ? 171 PHE A N   1 
ATOM   1089 C  CA  . PHE A 1 135 ? 9.12223   0.98250   39.86351  1.000 13.00271  ? 171 PHE A CA  1 
ATOM   1090 C  C   . PHE A 1 135 ? 10.17671  0.59595   38.83941  1.000 13.27674  ? 171 PHE A C   1 
ATOM   1091 O  O   . PHE A 1 135 ? 11.34264  0.38070   39.17879  1.000 12.65657  ? 171 PHE A O   1 
ATOM   1092 C  CB  . PHE A 1 135 ? 8.84576   2.48027   39.75760  1.000 12.41394  ? 171 PHE A CB  1 
ATOM   1093 C  CG  . PHE A 1 135 ? 7.70735   2.93391   40.64073  1.000 14.70022  ? 171 PHE A CG  1 
ATOM   1094 C  CD1 . PHE A 1 135 ? 6.42608   2.45335   40.41742  1.000 14.15563  ? 171 PHE A CD1 1 
ATOM   1095 C  CD2 . PHE A 1 135 ? 7.93514   3.81489   41.69169  1.000 17.03878  ? 171 PHE A CD2 1 
ATOM   1096 C  CE1 . PHE A 1 135 ? 5.36863   2.83229   41.21951  1.000 18.50714  ? 171 PHE A CE1 1 
ATOM   1097 C  CE2 . PHE A 1 135 ? 6.86408   4.21494   42.51897  1.000 18.00155  ? 171 PHE A CE2 1 
ATOM   1098 C  CZ  . PHE A 1 135 ? 5.59052   3.72110   42.27009  1.000 14.28247  ? 171 PHE A CZ  1 
ATOM   1099 N  N   . TYR A 1 136 ? 9.76743   0.48775   37.57031  1.000 11.71132  ? 172 TYR A N   1 
ATOM   1100 C  CA  . TYR A 1 136 ? 10.72929  0.05979   36.56889  1.000 12.26922  ? 172 TYR A CA  1 
ATOM   1101 C  C   . TYR A 1 136 ? 10.53606  0.86691   35.30229  1.000 12.59023  ? 172 TYR A C   1 
ATOM   1102 O  O   . TYR A 1 136 ? 9.45929   1.39383   35.04437  1.000 15.07173  ? 172 TYR A O   1 
ATOM   1103 C  CB  . TYR A 1 136 ? 10.60476  -1.44211  36.24674  1.000 12.91206  ? 172 TYR A CB  1 
ATOM   1104 C  CG  . TYR A 1 136 ? 9.18664   -1.94669  35.98618  1.000 15.60961  ? 172 TYR A CG  1 
ATOM   1105 C  CD1 . TYR A 1 136 ? 8.34739   -2.30642  37.03711  1.000 13.13539  ? 172 TYR A CD1 1 
ATOM   1106 C  CD2 . TYR A 1 136 ? 8.70351   -2.08421  34.67557  1.000 13.89700  ? 172 TYR A CD2 1 
ATOM   1107 C  CE1 . TYR A 1 136 ? 7.05261   -2.79786  36.80805  1.000 15.26119  ? 172 TYR A CE1 1 
ATOM   1108 C  CE2 . TYR A 1 136 ? 7.39987   -2.57528  34.43860  1.000 15.62781  ? 172 TYR A CE2 1 
ATOM   1109 C  CZ  . TYR A 1 136 ? 6.58927   -2.92801  35.51142  1.000 16.59726  ? 172 TYR A CZ  1 
ATOM   1110 O  OH  . TYR A 1 136 ? 5.31272   -3.42142  35.28970  1.000 17.87440  ? 172 TYR A OH  1 
ATOM   1111 N  N   . MET A 1 137 ? 11.59973  0.93533   34.50353  1.000 14.42520  ? 173 MET A N   1 
ATOM   1112 C  CA  A MET A 1 137 ? 11.58300  1.61981   33.21819  0.714 14.25087  ? 173 MET A CA  1 
ATOM   1113 C  CA  B MET A 1 137 ? 11.58579  1.62329   33.21889  0.286 14.18966  ? 173 MET A CA  1 
ATOM   1114 C  C   . MET A 1 137 ? 11.84618  0.62133   32.10095  1.000 14.13971  ? 173 MET A C   1 
ATOM   1115 O  O   . MET A 1 137 ? 12.87561  -0.06145  32.11484  1.000 14.88634  ? 173 MET A O   1 
ATOM   1116 C  CB  A MET A 1 137 ? 12.65290  2.71045   33.16174  0.714 15.51970  ? 173 MET A CB  1 
ATOM   1117 C  CB  B MET A 1 137 ? 12.64555  2.72534   33.19860  0.286 15.42275  ? 173 MET A CB  1 
ATOM   1118 C  CG  A MET A 1 137 ? 12.61818  3.42978   31.82367  0.714 14.62807  ? 173 MET A CG  1 
ATOM   1119 C  CG  B MET A 1 137 ? 12.86654  3.34454   31.83421  0.286 15.45468  ? 173 MET A CG  1 
ATOM   1120 S  SD  A MET A 1 137 ? 13.85690  4.74288   31.72362  0.714 17.86608  ? 173 MET A SD  1 
ATOM   1121 S  SD  B MET A 1 137 ? 11.92892  4.86696   31.62980  0.286 22.85332  ? 173 MET A SD  1 
ATOM   1122 C  CE  A MET A 1 137 ? 12.83983  6.15039   32.19233  0.714 22.97041  ? 173 MET A CE  1 
ATOM   1123 C  CE  B MET A 1 137 ? 13.00796  6.05861   32.42287  0.286 21.95039  ? 173 MET A CE  1 
ATOM   1124 N  N   . CYS A 1 138 ? 10.92684  0.54623   31.13448  1.000 12.16506  ? 174 CYS A N   1 
ATOM   1125 C  CA  . CYS A 1 138 ? 11.13731  -0.26006  29.93467  1.000 13.05774  ? 174 CYS A CA  1 
ATOM   1126 C  C   . CYS A 1 138 ? 11.69883  0.63981   28.84432  1.000 15.21602  ? 174 CYS A C   1 
ATOM   1127 O  O   . CYS A 1 138 ? 11.41689  1.83903   28.80462  1.000 15.03298  ? 174 CYS A O   1 
ATOM   1128 C  CB  . CYS A 1 138 ? 9.83814   -0.85319  29.39416  1.000 16.72733  ? 174 CYS A CB  1 
ATOM   1129 S  SG  . CYS A 1 138 ? 8.89954   -1.85384  30.52695  1.000 17.25420  ? 174 CYS A SG  1 
ATOM   1130 N  N   . GLU A 1 139 ? 12.45136  0.04548   27.92442  1.000 16.06438  ? 175 GLU A N   1 
ATOM   1131 C  CA  . GLU A 1 139 ? 12.91580  0.78068   26.75661  1.000 14.49936  ? 175 GLU A CA  1 
ATOM   1132 C  C   . GLU A 1 139 ? 12.69150  -0.08526  25.52945  1.000 14.76719  ? 175 GLU A C   1 
ATOM   1133 O  O   . GLU A 1 139 ? 13.01632  -1.27470  25.53693  1.000 16.97102  ? 175 GLU A O   1 
ATOM   1134 C  CB  . GLU A 1 139 ? 14.40721  1.12878   26.84498  1.000 15.87520  ? 175 GLU A CB  1 
ATOM   1135 C  CG  . GLU A 1 139 ? 14.91036  1.87763   25.61454  1.000 15.79170  ? 175 GLU A CG  1 
ATOM   1136 C  CD  . GLU A 1 139 ? 16.41375  2.11892   25.63303  1.000 17.69081  ? 175 GLU A CD  1 
ATOM   1137 O  OE1 . GLU A 1 139 ? 17.11034  1.63157   26.55773  1.000 15.72245  ? 175 GLU A OE1 1 
ATOM   1138 O  OE2 . GLU A 1 139 ? 16.89196  2.80814   24.70781  1.000 16.62917  ? 175 GLU A OE2 1 
ATOM   1139 N  N   . LYS A 1 140 ? 12.18011  0.53065   24.46951  1.000 15.20094  ? 176 LYS A N   1 
ATOM   1140 C  CA  . LYS A 1 140 ? 11.98458  -0.13778  23.18736  1.000 19.28339  ? 176 LYS A CA  1 
ATOM   1141 C  C   . LYS A 1 140 ? 12.70579  0.69665   22.14093  1.000 19.32149  ? 176 LYS A C   1 
ATOM   1142 O  O   . LYS A 1 140 ? 12.24832  1.79366   21.80367  1.000 18.75261  ? 176 LYS A O   1 
ATOM   1143 C  CB  . LYS A 1 140 ? 10.49997  -0.24506  22.86109  1.000 19.75881  ? 176 LYS A CB  1 
ATOM   1144 C  CG  . LYS A 1 140 ? 10.18476  -1.00046  21.61368  1.000 21.76946  ? 176 LYS A CG  1 
ATOM   1145 C  CD  . LYS A 1 140 ? 8.74720   -0.71119  21.21865  1.000 25.19130  ? 176 LYS A CD  1 
ATOM   1146 C  CE  . LYS A 1 140 ? 8.26915   -1.68493  20.18318  1.000 28.93499  ? 176 LYS A CE  1 
ATOM   1147 N  NZ  . LYS A 1 140 ? 7.61646   -2.90157  20.80159  1.000 24.88043  ? 176 LYS A NZ  1 
ATOM   1148 N  N   . ARG A 1 141 ? 13.84012  0.19884   21.65853  1.000 17.76983  ? 177 ARG A N   1 
ATOM   1149 C  CA  . ARG A 1 141 ? 14.59871  0.88188   20.62145  1.000 20.40679  ? 177 ARG A CA  1 
ATOM   1150 C  C   . ARG A 1 141 ? 13.83500  0.69266   19.31846  1.000 22.59900  ? 177 ARG A C   1 
ATOM   1151 O  O   . ARG A 1 141 ? 13.77725  -0.42379  18.79761  1.000 25.89691  ? 177 ARG A O   1 
ATOM   1152 C  CB  . ARG A 1 141 ? 16.01127  0.29793   20.54511  1.000 28.12262  ? 177 ARG A CB  1 
ATOM   1153 C  CG  . ARG A 1 141 ? 17.06221  1.18171   19.87306  1.000 39.23389  ? 177 ARG A CG  1 
ATOM   1154 C  CD  . ARG A 1 141 ? 16.93954  1.10746   18.35479  1.000 45.11314  ? 177 ARG A CD  1 
ATOM   1155 N  NE  . ARG A 1 141 ? 18.04487  1.72106   17.62038  1.000 47.98672  ? 177 ARG A NE  1 
ATOM   1156 C  CZ  . ARG A 1 141 ? 19.31762  1.35199   17.69196  1.000 53.65004  ? 177 ARG A CZ  1 
ATOM   1157 N  NH1 . ARG A 1 141 ? 19.70374  0.31828   18.42547  1.000 57.69301  ? 177 ARG A NH1 1 
ATOM   1158 N  NH2 . ARG A 1 141 ? 20.22544  2.02503   16.99178  1.000 53.52863  ? 177 ARG A NH2 1 
ATOM   1159 N  N   . ILE A 1 142 ? 13.26863  1.78190   18.79291  1.000 20.99126  ? 178 ILE A N   1 
ATOM   1160 C  CA  . ILE A 1 142 ? 12.31347  1.72672   17.69876  1.000 22.29431  ? 178 ILE A CA  1 
ATOM   1161 C  C   . ILE A 1 142 ? 12.89211  2.25864   16.38596  1.000 28.76747  ? 178 ILE A C   1 
ATOM   1162 O  O   . ILE A 1 142 ? 12.45663  1.82693   15.31082  1.000 25.78251  ? 178 ILE A O   1 
ATOM   1163 C  CB  . ILE A 1 142 ? 11.02318  2.49634   18.09148  1.000 32.70006  ? 178 ILE A CB  1 
ATOM   1164 C  CG1 . ILE A 1 142 ? 9.85386   2.15739   17.17028  1.000 45.70993  ? 178 ILE A CG1 1 
ATOM   1165 C  CG2 . ILE A 1 142 ? 11.24434  3.99083   18.11296  1.000 30.55742  ? 178 ILE A CG2 1 
ATOM   1166 C  CD1 . ILE A 1 142 ? 9.37060   0.76300   17.33170  1.000 47.07195  ? 178 ILE A CD1 1 
ATOM   1167 N  N   . PHE A 1 143 ? 13.88572  3.14602   16.43836  1.000 24.15356  ? 179 PHE A N   1 
ATOM   1168 C  CA  . PHE A 1 143 ? 14.45735  3.76819   15.25198  1.000 29.71271  ? 179 PHE A CA  1 
ATOM   1169 C  C   . PHE A 1 143 ? 15.90027  3.30699   15.07626  1.000 25.40245  ? 179 PHE A C   1 
ATOM   1170 O  O   . PHE A 1 143 ? 16.62247  3.16867   16.06446  1.000 28.00298  ? 179 PHE A O   1 
ATOM   1171 C  CB  . PHE A 1 143 ? 14.43838  5.30054   15.36349  1.000 27.58508  ? 179 PHE A CB  1 
ATOM   1172 C  CG  . PHE A 1 143 ? 13.05728  5.89875   15.35252  1.000 32.23374  ? 179 PHE A CG  1 
ATOM   1173 C  CD1 . PHE A 1 143 ? 12.63965  6.70816   16.40264  1.000 32.97635  ? 179 PHE A CD1 1 
ATOM   1174 C  CD2 . PHE A 1 143 ? 12.16948  5.62863   14.32698  1.000 31.82062  ? 179 PHE A CD2 1 
ATOM   1175 C  CE1 . PHE A 1 143 ? 11.37082  7.26003   16.41099  1.000 33.24930  ? 179 PHE A CE1 1 
ATOM   1176 C  CE2 . PHE A 1 143 ? 10.89748  6.17372   14.32732  1.000 42.98650  ? 179 PHE A CE2 1 
ATOM   1177 C  CZ  . PHE A 1 143 ? 10.49613  6.98958   15.37464  1.000 41.28672  ? 179 PHE A CZ  1 
ATOM   1178 N  N   . PRO A 1 144 ? 16.36347  3.07640   13.84119  1.000 32.03950  ? 180 PRO A N   1 
ATOM   1179 C  CA  . PRO A 1 144 ? 17.72615  2.55291   13.64114  1.000 29.75976  ? 180 PRO A CA  1 
ATOM   1180 C  C   . PRO A 1 144 ? 18.83735  3.45893   14.17427  1.000 32.74150  ? 180 PRO A C   1 
ATOM   1181 O  O   . PRO A 1 144 ? 18.86190  4.63197   13.80443  1.000 46.16464  ? 180 PRO A O   1 
ATOM   1182 C  CB  . PRO A 1 144 ? 17.85484  2.42123   12.11660  1.000 36.93173  ? 180 PRO A CB  1 
ATOM   1183 C  CG  . PRO A 1 144 ? 16.60420  2.92860   11.52729  1.000 40.98965  ? 180 PRO A CG  1 
ATOM   1184 C  CD  . PRO A 1 144 ? 15.61994  3.27576   12.58804  1.000 40.49534  ? 180 PRO A CD  1 
ATOM   1185 N  N   . PHE B 1 11  ? 16.76285  -25.95013 31.19863  1.000 55.84708  ? 47  PHE B N   1 
ATOM   1186 C  CA  . PHE B 1 11  ? 17.90252  -25.73949 30.30943  1.000 57.78884  ? 47  PHE B CA  1 
ATOM   1187 C  C   . PHE B 1 11  ? 18.89613  -26.89209 30.31660  1.000 59.75025  ? 47  PHE B C   1 
ATOM   1188 O  O   . PHE B 1 11  ? 19.64472  -27.06744 29.36262  1.000 63.02142  ? 47  PHE B O   1 
ATOM   1189 C  CB  . PHE B 1 11  ? 18.63181  -24.44177 30.65744  1.000 63.84149  ? 47  PHE B CB  1 
ATOM   1190 C  CG  . PHE B 1 11  ? 18.30812  -23.30571 29.73185  1.000 70.80043  ? 47  PHE B CG  1 
ATOM   1191 C  CD1 . PHE B 1 11  ? 18.49125  -23.44502 28.36224  1.000 55.60438  ? 47  PHE B CD1 1 
ATOM   1192 C  CD2 . PHE B 1 11  ? 17.82360  -22.10262 30.22183  1.000 64.84853  ? 47  PHE B CD2 1 
ATOM   1193 C  CE1 . PHE B 1 11  ? 18.19400  -22.40767 27.49778  1.000 52.58163  ? 47  PHE B CE1 1 
ATOM   1194 C  CE2 . PHE B 1 11  ? 17.52660  -21.05759 29.36132  1.000 54.48464  ? 47  PHE B CE2 1 
ATOM   1195 C  CZ  . PHE B 1 11  ? 17.71174  -21.21096 27.99664  1.000 46.95418  ? 47  PHE B CZ  1 
ATOM   1196 N  N   . ASP B 1 12  ? 18.93246  -27.67480 31.38912  1.000 54.98682  ? 48  ASP B N   1 
ATOM   1197 C  CA  . ASP B 1 12  ? 19.66663  -28.92537 31.29095  1.000 62.54146  ? 48  ASP B CA  1 
ATOM   1198 C  C   . ASP B 1 12  ? 18.87174  -29.98128 30.54483  1.000 56.38441  ? 48  ASP B C   1 
ATOM   1199 O  O   . ASP B 1 12  ? 19.45538  -30.95786 30.06244  1.000 48.91365  ? 48  ASP B O   1 
ATOM   1200 C  CB  . ASP B 1 12  ? 20.07527  -29.43312 32.67494  1.000 70.49299  ? 48  ASP B CB  1 
ATOM   1201 C  CG  . ASP B 1 12  ? 21.44942  -28.94063 33.08133  1.000 74.20873  ? 48  ASP B CG  1 
ATOM   1202 O  OD1 . ASP B 1 12  ? 21.84915  -27.85433 32.60890  1.000 80.73633  ? 48  ASP B OD1 1 
ATOM   1203 O  OD2 . ASP B 1 12  ? 22.14021  -29.64922 33.84467  1.000 87.51565  ? 48  ASP B OD2 1 
ATOM   1204 N  N   . LYS B 1 13  ? 17.55906  -29.79912 30.42110  1.000 37.19693  ? 49  LYS B N   1 
ATOM   1205 C  CA  . LYS B 1 13  ? 16.80446  -30.64286 29.50659  1.000 50.92187  ? 49  LYS B CA  1 
ATOM   1206 C  C   . LYS B 1 13  ? 17.09158  -30.25734 28.05748  1.000 42.91230  ? 49  LYS B C   1 
ATOM   1207 O  O   . LYS B 1 13  ? 17.30980  -31.12700 27.20731  1.000 36.38475  ? 49  LYS B O   1 
ATOM   1208 C  CB  . LYS B 1 13  ? 15.30732  -30.54960 29.81144  1.000 49.04395  ? 49  LYS B CB  1 
ATOM   1209 C  CG  . LYS B 1 13  ? 14.80745  -31.66747 30.70940  1.000 65.93161  ? 49  LYS B CG  1 
ATOM   1210 C  CD  . LYS B 1 13  ? 13.30110  -31.86697 30.63085  1.000 66.77851  ? 49  LYS B CD  1 
ATOM   1211 C  CE  . LYS B 1 13  ? 12.98253  -33.31471 30.27810  1.000 63.42283  ? 49  LYS B CE  1 
ATOM   1212 N  NZ  . LYS B 1 13  ? 11.55041  -33.53053 29.93968  1.000 59.80216  ? 49  LYS B NZ  1 
ATOM   1213 N  N   . LEU B 1 14  ? 17.13465  -28.94959 27.76621  1.000 45.11910  ? 50  LEU B N   1 
ATOM   1214 C  CA  . LEU B 1 14  ? 17.15862  -28.47937 26.38045  1.000 32.10194  ? 50  LEU B CA  1 
ATOM   1215 C  C   . LEU B 1 14  ? 18.56177  -28.42691 25.78970  1.000 31.70915  ? 50  LEU B C   1 
ATOM   1216 O  O   . LEU B 1 14  ? 18.71421  -28.52618 24.56415  1.000 29.33027  ? 50  LEU B O   1 
ATOM   1217 C  CB  . LEU B 1 14  ? 16.52491  -27.08693 26.28151  1.000 27.53650  ? 50  LEU B CB  1 
ATOM   1218 C  CG  . LEU B 1 14  ? 15.13393  -26.91829 26.89694  1.000 34.61767  ? 50  LEU B CG  1 
ATOM   1219 C  CD1 . LEU B 1 14  ? 14.54106  -25.56579 26.53696  1.000 32.37582  ? 50  LEU B CD1 1 
ATOM   1220 C  CD2 . LEU B 1 14  ? 14.21368  -28.04405 26.45151  1.000 36.06633  ? 50  LEU B CD2 1 
ATOM   1221 N  N   . ASP B 1 15  ? 19.58652  -28.23729 26.61989  1.000 31.67823  ? 51  ASP B N   1 
ATOM   1222 C  CA  . ASP B 1 15  ? 20.92644  -28.00766 26.08418  1.000 29.16505  ? 51  ASP B CA  1 
ATOM   1223 C  C   . ASP B 1 15  ? 21.44935  -29.13689 25.20428  1.000 32.59719  ? 51  ASP B C   1 
ATOM   1224 O  O   . ASP B 1 15  ? 22.04581  -28.82604 24.15864  1.000 33.65526  ? 51  ASP B O   1 
ATOM   1225 C  CB  . ASP B 1 15  ? 21.91385  -27.72390 27.22509  1.000 50.17140  ? 51  ASP B CB  1 
ATOM   1226 C  CG  . ASP B 1 15  ? 21.90774  -26.26389 27.65356  1.000 58.29287  ? 51  ASP B CG  1 
ATOM   1227 O  OD1 . ASP B 1 15  ? 21.34893  -25.42805 26.91290  1.000 64.10439  ? 51  ASP B OD1 1 
ATOM   1228 O  OD2 . ASP B 1 15  ? 22.45768  -25.94938 28.73071  1.000 68.15552  ? 51  ASP B OD2 1 
ATOM   1229 N  N   . PRO B 1 16  ? 21.30082  -30.42544 25.54398  1.000 34.58648  ? 52  PRO B N   1 
ATOM   1230 C  CA  . PRO B 1 16  ? 21.78344  -31.46092 24.60902  1.000 37.22452  ? 52  PRO B CA  1 
ATOM   1231 C  C   . PRO B 1 16  ? 21.03937  -31.46203 23.28368  1.000 30.50097  ? 52  PRO B C   1 
ATOM   1232 O  O   . PRO B 1 16  ? 21.60754  -31.86699 22.26222  1.000 31.34998  ? 52  PRO B O   1 
ATOM   1233 C  CB  . PRO B 1 16  ? 21.57845  -32.77805 25.37161  1.000 38.60819  ? 52  PRO B CB  1 
ATOM   1234 C  CG  . PRO B 1 16  ? 21.14981  -32.41875 26.74557  1.000 40.71243  ? 52  PRO B CG  1 
ATOM   1235 C  CD  . PRO B 1 16  ? 20.70760  -31.00187 26.76610  1.000 38.79352  ? 52  PRO B CD  1 
ATOM   1236 N  N   . TYR B 1 17  ? 19.78212  -31.01870 23.27154  1.000 29.09281  ? 53  TYR B N   1 
ATOM   1237 C  CA  . TYR B 1 17  ? 19.05387  -30.89355 22.01480  1.000 25.77854  ? 53  TYR B CA  1 
ATOM   1238 C  C   . TYR B 1 17  ? 19.51352  -29.67340 21.23255  1.000 25.93639  ? 53  TYR B C   1 
ATOM   1239 O  O   . TYR B 1 17  ? 19.73539  -29.76068 20.01847  1.000 24.53995  ? 53  TYR B O   1 
ATOM   1240 C  CB  . TYR B 1 17  ? 17.55420  -30.82416 22.27597  1.000 28.17829  ? 53  TYR B CB  1 
ATOM   1241 C  CG  . TYR B 1 17  ? 16.97941  -32.12401 22.76402  1.000 30.79078  ? 53  TYR B CG  1 
ATOM   1242 C  CD1 . TYR B 1 17  ? 16.99178  -32.44227 24.12068  1.000 35.22062  ? 53  TYR B CD1 1 
ATOM   1243 C  CD2 . TYR B 1 17  ? 16.43356  -33.03702 21.87519  1.000 25.21613  ? 53  TYR B CD2 1 
ATOM   1244 C  CE1 . TYR B 1 17  ? 16.46212  -33.63111 24.57885  1.000 37.85463  ? 53  TYR B CE1 1 
ATOM   1245 C  CE2 . TYR B 1 17  ? 15.90079  -34.23088 22.32273  1.000 35.41474  ? 53  TYR B CE2 1 
ATOM   1246 C  CZ  . TYR B 1 17  ? 15.91721  -34.52165 23.67691  1.000 39.15917  ? 53  TYR B CZ  1 
ATOM   1247 O  OH  . TYR B 1 17  ? 15.38898  -35.70997 24.12693  1.000 43.55371  ? 53  TYR B OH  1 
ATOM   1248 N  N   . PHE B 1 18  ? 19.65135  -28.51850 21.90407  1.000 23.25160  ? 54  PHE B N   1 
ATOM   1249 C  CA  . PHE B 1 18  ? 20.16887  -27.33814 21.21122  1.000 21.46487  ? 54  PHE B CA  1 
ATOM   1250 C  C   . PHE B 1 18  ? 21.51777  -27.64569 20.56135  1.000 25.89191  ? 54  PHE B C   1 
ATOM   1251 O  O   . PHE B 1 18  ? 21.79545  -27.20855 19.43666  1.000 23.07206  ? 54  PHE B O   1 
ATOM   1252 C  CB  . PHE B 1 18  ? 20.32324  -26.15413 22.17689  1.000 23.13294  ? 54  PHE B CB  1 
ATOM   1253 C  CG  . PHE B 1 18  ? 19.02241  -25.54114 22.65007  1.000 21.24198  ? 54  PHE B CG  1 
ATOM   1254 C  CD1 . PHE B 1 18  ? 17.86625  -25.59304 21.87936  1.000 18.71695  ? 54  PHE B CD1 1 
ATOM   1255 C  CD2 . PHE B 1 18  ? 18.98034  -24.86056 23.87367  1.000 19.46423  ? 54  PHE B CD2 1 
ATOM   1256 C  CE1 . PHE B 1 18  ? 16.67645  -25.00802 22.33369  1.000 18.69570  ? 54  PHE B CE1 1 
ATOM   1257 C  CE2 . PHE B 1 18  ? 17.81004  -24.27958 24.32709  1.000 17.90353  ? 54  PHE B CE2 1 
ATOM   1258 C  CZ  . PHE B 1 18  ? 16.64950  -24.34702 23.55002  1.000 19.39968  ? 54  PHE B CZ  1 
ATOM   1259 N  N   . GLN B 1 19  ? 22.36456  -28.41239 21.25547  1.000 28.73506  ? 55  GLN B N   1 
ATOM   1260 C  CA  . GLN B 1 19  ? 23.66713  -28.76965 20.70431  1.000 33.26516  ? 55  GLN B CA  1 
ATOM   1261 C  C   . GLN B 1 19  ? 23.55929  -29.61679 19.43652  1.000 34.70061  ? 55  GLN B C   1 
ATOM   1262 O  O   . GLN B 1 19  ? 24.51328  -29.66667 18.65403  1.000 33.67351  ? 55  GLN B O   1 
ATOM   1263 C  CB  . GLN B 1 19  ? 24.49634  -29.50052 21.76399  1.000 40.05550  ? 55  GLN B CB  1 
ATOM   1264 C  CG  . GLN B 1 19  ? 24.94529  -28.60653 22.92218  1.000 50.63760  ? 55  GLN B CG  1 
ATOM   1265 C  CD  . GLN B 1 19  ? 25.34206  -29.39804 24.16417  1.000 64.78809  ? 55  GLN B CD  1 
ATOM   1266 O  OE1 . GLN B 1 19  ? 25.77564  -30.54823 24.06935  1.000 73.73041  ? 55  GLN B OE1 1 
ATOM   1267 N  NE2 . GLN B 1 19  ? 25.19294  -28.78237 25.33578  1.000 61.53906  ? 55  GLN B NE2 1 
ATOM   1268 N  N   . GLN B 1 20  ? 22.43163  -30.28095 19.20097  1.000 31.01077  ? 56  GLN B N   1 
ATOM   1269 C  CA  . GLN B 1 20  ? 22.24826  -31.02646 17.95931  1.000 28.48269  ? 56  GLN B CA  1 
ATOM   1270 C  C   . GLN B 1 20  ? 21.36002  -30.29779 16.95713  1.000 31.04229  ? 56  GLN B C   1 
ATOM   1271 O  O   . GLN B 1 20  ? 20.95773  -30.89971 15.95560  1.000 29.78762  ? 56  GLN B O   1 
ATOM   1272 C  CB  . GLN B 1 20  ? 21.68358  -32.42254 18.23926  1.000 30.26665  ? 56  GLN B CB  1 
ATOM   1273 C  CG  . GLN B 1 20  ? 22.45897  -33.21142 19.30027  1.000 32.14510  ? 56  GLN B CG  1 
ATOM   1274 C  CD  . GLN B 1 20  ? 23.84093  -33.63292 18.83031  1.000 48.38734  ? 56  GLN B CD  1 
ATOM   1275 O  OE1 . GLN B 1 20  ? 24.20282  -33.44669 17.66620  1.000 58.63923  ? 56  GLN B OE1 1 
ATOM   1276 N  NE2 . GLN B 1 20  ? 24.63470  -34.17473 19.74818  1.000 60.00385  ? 56  GLN B NE2 1 
ATOM   1277 N  N   . GLY B 1 21  ? 21.04934  -29.02092 17.19941  1.000 24.82496  ? 57  GLY B N   1 
ATOM   1278 C  CA  . GLY B 1 21  ? 20.29800  -28.21812 16.25332  1.000 22.44623  ? 57  GLY B CA  1 
ATOM   1279 C  C   . GLY B 1 21  ? 18.79378  -28.19551 16.44690  1.000 17.98323  ? 57  GLY B C   1 
ATOM   1280 O  O   . GLY B 1 21  ? 18.08979  -27.61149 15.60119  1.000 20.53434  ? 57  GLY B O   1 
ATOM   1281 N  N   . TRP B 1 22  ? 18.27807  -28.81866 17.50884  1.000 19.27948  ? 58  TRP B N   1 
ATOM   1282 C  CA  . TRP B 1 22  ? 16.84997  -28.73294 17.78378  1.000 15.85181  ? 58  TRP B CA  1 
ATOM   1283 C  C   . TRP B 1 22  ? 16.50561  -27.33907 18.27820  1.000 17.48046  ? 58  TRP B C   1 
ATOM   1284 O  O   . TRP B 1 22  ? 17.36489  -26.60140 18.76919  1.000 18.31469  ? 58  TRP B O   1 
ATOM   1285 C  CB  . TRP B 1 22  ? 16.42174  -29.74507 18.85511  1.000 18.22283  ? 58  TRP B CB  1 
ATOM   1286 C  CG  . TRP B 1 22  ? 16.61654  -31.16611 18.46736  1.000 21.72471  ? 58  TRP B CG  1 
ATOM   1287 C  CD1 . TRP B 1 22  ? 17.80868  -31.78605 18.20394  1.000 27.86971  ? 58  TRP B CD1 1 
ATOM   1288 C  CD2 . TRP B 1 22  ? 15.60402  -32.17982 18.35555  1.000 19.94667  ? 58  TRP B CD2 1 
ATOM   1289 N  NE1 . TRP B 1 22  ? 17.59873  -33.11223 17.90707  1.000 27.56901  ? 58  TRP B NE1 1 
ATOM   1290 C  CE2 . TRP B 1 22  ? 16.25754  -33.38298 17.99667  1.000 22.31066  ? 58  TRP B CE2 1 
ATOM   1291 C  CE3 . TRP B 1 22  ? 14.21250  -32.18415 18.50758  1.000 18.88069  ? 58  TRP B CE3 1 
ATOM   1292 C  CZ2 . TRP B 1 22  ? 15.56962  -34.58215 17.79797  1.000 21.29590  ? 58  TRP B CZ2 1 
ATOM   1293 C  CZ3 . TRP B 1 22  ? 13.52466  -33.37823 18.29949  1.000 18.74293  ? 58  TRP B CZ3 1 
ATOM   1294 C  CH2 . TRP B 1 22  ? 14.21096  -34.56366 17.94401  1.000 17.22670  ? 58  TRP B CH2 1 
ATOM   1295 N  N   . PHE B 1 23  ? 15.22215  -26.99449 18.20886  1.000 15.88779  ? 59  PHE B N   1 
ATOM   1296 C  CA  . PHE B 1 23  ? 14.79530  -25.71470 18.75713  1.000 16.01721  ? 59  PHE B CA  1 
ATOM   1297 C  C   . PHE B 1 23  ? 13.42344  -25.87861 19.39208  1.000 16.49801  ? 59  PHE B C   1 
ATOM   1298 O  O   . PHE B 1 23  ? 12.71704  -26.86355 19.15548  1.000 15.51758  ? 59  PHE B O   1 
ATOM   1299 C  CB  . PHE B 1 23  ? 14.80465  -24.60828 17.67730  1.000 13.51208  ? 59  PHE B CB  1 
ATOM   1300 C  CG  . PHE B 1 23  ? 14.16311  -25.03028 16.37505  1.000 17.44436  ? 59  PHE B CG  1 
ATOM   1301 C  CD1 . PHE B 1 23  ? 14.91127  -25.71156 15.40308  1.000 21.03604  ? 59  PHE B CD1 1 
ATOM   1302 C  CD2 . PHE B 1 23  ? 12.82206  -24.77003 16.13784  1.000 17.48176  ? 59  PHE B CD2 1 
ATOM   1303 C  CE1 . PHE B 1 23  ? 14.32231  -26.13534 14.21341  1.000 16.92708  ? 59  PHE B CE1 1 
ATOM   1304 C  CE2 . PHE B 1 23  ? 12.21800  -25.18157 14.95121  1.000 18.34657  ? 59  PHE B CE2 1 
ATOM   1305 C  CZ  . PHE B 1 23  ? 12.97792  -25.85239 13.97928  1.000 17.37773  ? 59  PHE B CZ  1 
ATOM   1306 N  N   . HIS B 1 24  ? 13.06538  -24.90325 20.21904  1.000 16.32416  ? 60  HIS B N   1 
ATOM   1307 C  CA  . HIS B 1 24  ? 11.97497  -25.03080 21.17859  1.000 17.57234  ? 60  HIS B CA  1 
ATOM   1308 C  C   . HIS B 1 24  ? 10.81429  -24.11538 20.80460  1.000 15.26038  ? 60  HIS B C   1 
ATOM   1309 O  O   . HIS B 1 24  ? 10.99542  -22.90809 20.56965  1.000 15.88306  ? 60  HIS B O   1 
ATOM   1310 C  CB  . HIS B 1 24  ? 12.51862  -24.73018 22.58819  1.000 17.41215  ? 60  HIS B CB  1 
ATOM   1311 C  CG  . HIS B 1 24  ? 11.46490  -24.52968 23.63592  1.000 20.85543  ? 60  HIS B CG  1 
ATOM   1312 N  ND1 . HIS B 1 24  ? 11.59557  -23.58947 24.63974  1.000 18.64296  ? 60  HIS B ND1 1 
ATOM   1313 C  CD2 . HIS B 1 24  ? 10.28681  -25.16169 23.86006  1.000 24.96649  ? 60  HIS B CD2 1 
ATOM   1314 C  CE1 . HIS B 1 24  ? 10.52615  -23.62986 25.41738  1.000 22.45909  ? 60  HIS B CE1 1 
ATOM   1315 N  NE2 . HIS B 1 24  ? 9.71969   -24.57624 24.96851  1.000 23.78403  ? 60  HIS B NE2 1 
ATOM   1316 N  N   . PHE B 1 25  ? 9.61197   -24.69297 20.74869  1.000 14.93091  ? 61  PHE B N   1 
ATOM   1317 C  CA  . PHE B 1 25  ? 8.39865   -23.93438 20.48039  1.000 16.44147  ? 61  PHE B CA  1 
ATOM   1318 C  C   . PHE B 1 25  ? 7.27803   -24.55889 21.29816  1.000 17.62629  ? 61  PHE B C   1 
ATOM   1319 O  O   . PHE B 1 25  ? 7.00461   -25.75308 21.15552  1.000 16.67796  ? 61  PHE B O   1 
ATOM   1320 C  CB  . PHE B 1 25  ? 8.04956   -23.93451 18.97169  1.000 18.81203  ? 61  PHE B CB  1 
ATOM   1321 C  CG  . PHE B 1 25  ? 6.73973   -23.25273 18.64177  1.000 18.27069  ? 61  PHE B CG  1 
ATOM   1322 C  CD1 . PHE B 1 25  ? 6.66071   -21.86401 18.57759  1.000 17.22430  ? 61  PHE B CD1 1 
ATOM   1323 C  CD2 . PHE B 1 25  ? 5.58182   -24.00221 18.39446  1.000 16.78048  ? 61  PHE B CD2 1 
ATOM   1324 C  CE1 . PHE B 1 25  ? 5.44346   -21.23374 18.29099  1.000 20.93225  ? 61  PHE B CE1 1 
ATOM   1325 C  CE2 . PHE B 1 25  ? 4.35982   -23.37727 18.09838  1.000 15.97633  ? 61  PHE B CE2 1 
ATOM   1326 C  CZ  . PHE B 1 25  ? 4.29314   -21.99322 18.04484  1.000 19.55785  ? 61  PHE B CZ  1 
ATOM   1327 N  N   . GLN B 1 26  ? 6.65878   -23.76730 22.17032  1.000 20.67882  ? 62  GLN B N   1 
ATOM   1328 C  CA  . GLN B 1 26  ? 5.46251   -24.17636 22.92109  1.000 21.11523  ? 62  GLN B CA  1 
ATOM   1329 C  C   . GLN B 1 26  ? 5.59621   -25.58414 23.52098  1.000 21.99338  ? 62  GLN B C   1 
ATOM   1330 O  O   . GLN B 1 26  ? 4.80170   -26.48563 23.25207  1.000 26.65147  ? 62  GLN B O   1 
ATOM   1331 C  CB  . GLN B 1 26  ? 4.22197   -24.07598 22.02651  1.000 21.84860  ? 62  GLN B CB  1 
ATOM   1332 C  CG  . GLN B 1 26  ? 3.89641   -22.63749 21.63478  1.000 20.94241  ? 62  GLN B CG  1 
ATOM   1333 C  CD  . GLN B 1 26  ? 2.45283   -22.43295 21.17406  1.000 31.64793  ? 62  GLN B CD  1 
ATOM   1334 O  OE1 . GLN B 1 26  ? 1.82191   -23.33758 20.61001  1.000 25.94352  ? 62  GLN B OE1 1 
ATOM   1335 N  NE2 . GLN B 1 26  ? 1.92821   -21.23340 21.41098  1.000 29.92595  ? 62  GLN B NE2 1 
ATOM   1336 N  N   . LYS B 1 27  ? 6.63068   -25.76649 24.34037  1.000 21.76368  ? 63  LYS B N   1 
ATOM   1337 C  CA  . LYS B 1 27  ? 6.85625   -26.98071 25.13673  1.000 31.11226  ? 63  LYS B CA  1 
ATOM   1338 C  C   . LYS B 1 27  ? 7.25241   -28.21101 24.32097  1.000 28.35559  ? 63  LYS B C   1 
ATOM   1339 O  O   . LYS B 1 27  ? 7.35123   -29.31024 24.88531  1.000 23.67526  ? 63  LYS B O   1 
ATOM   1340 C  CB  . LYS B 1 27  ? 5.64771   -27.34195 26.02100  1.000 36.97652  ? 63  LYS B CB  1 
ATOM   1341 C  CG  . LYS B 1 27  ? 5.13401   -26.17985 26.88585  1.000 55.15335  ? 63  LYS B CG  1 
ATOM   1342 C  CD  . LYS B 1 27  ? 3.99919   -26.58919 27.84106  1.000 61.00207  ? 63  LYS B CD  1 
ATOM   1343 C  CE  . LYS B 1 27  ? 3.27481   -27.83220 27.36045  1.000 68.85937  ? 63  LYS B CE  1 
ATOM   1344 N  NZ  . LYS B 1 27  ? 1.98445   -28.12545 28.04906  1.000 82.14153  ? 63  LYS B NZ  1 
ATOM   1345 N  N   . SER B 1 28  ? 7.53062   -28.06660 23.02581  1.000 19.71799  ? 64  SER B N   1 
ATOM   1346 C  CA  . SER B 1 28  ? 8.17637   -29.12484 22.26580  1.000 16.89667  ? 64  SER B CA  1 
ATOM   1347 C  C   . SER B 1 28  ? 9.52630   -28.67692 21.73427  1.000 15.26585  ? 64  SER B C   1 
ATOM   1348 O  O   . SER B 1 28  ? 9.78275   -27.48747 21.54503  1.000 16.15123  ? 64  SER B O   1 
ATOM   1349 C  CB  . SER B 1 28  ? 7.33653   -29.57136 21.06174  1.000 22.12687  ? 64  SER B CB  1 
ATOM   1350 O  OG  . SER B 1 28  ? 6.15029   -30.21123 21.46862  1.000 21.10464  ? 64  SER B OG  1 
ATOM   1351 N  N   . LEU B 1 29  ? 10.35597  -29.67162 21.45616  1.000 15.08634  ? 65  LEU B N   1 
ATOM   1352 C  CA  . LEU B 1 29  ? 11.58663  -29.51310 20.69817  1.000 15.46290  ? 65  LEU B CA  1 
ATOM   1353 C  C   . LEU B 1 29  ? 11.36244  -30.06478 19.29544  1.000 19.40913  ? 65  LEU B C   1 
ATOM   1354 O  O   . LEU B 1 29  ? 10.70957  -31.10413 19.11539  1.000 18.73427  ? 65  LEU B O   1 
ATOM   1355 C  CB  . LEU B 1 29  ? 12.74192  -30.25177 21.37261  1.000 16.16689  ? 65  LEU B CB  1 
ATOM   1356 C  CG  . LEU B 1 29  ? 13.25224  -29.50439 22.60499  1.000 20.97685  ? 65  LEU B CG  1 
ATOM   1357 C  CD1 . LEU B 1 29  ? 13.99259  -30.49766 23.50279  1.000 23.80840  ? 65  LEU B CD1 1 
ATOM   1358 C  CD2 . LEU B 1 29  ? 14.13991  -28.33340 22.19785  1.000 25.32545  ? 65  LEU B CD2 1 
ATOM   1359 N  N   . TYR B 1 30  ? 11.89337  -29.35553 18.30489  1.000 14.65262  ? 66  TYR B N   1 
ATOM   1360 C  CA  . TYR B 1 30  ? 11.70825  -29.71968 16.91254  1.000 15.50316  ? 66  TYR B CA  1 
ATOM   1361 C  C   . TYR B 1 30  ? 13.06672  -29.81724 16.24055  1.000 15.60773  ? 66  TYR B C   1 
ATOM   1362 O  O   . TYR B 1 30  ? 14.01628  -29.10316 16.59655  1.000 15.59227  ? 66  TYR B O   1 
ATOM   1363 C  CB  . TYR B 1 30  ? 10.87880  -28.68772 16.18060  1.000 15.48513  ? 66  TYR B CB  1 
ATOM   1364 C  CG  . TYR B 1 30  ? 9.47734   -28.53486 16.71274  1.000 17.66855  ? 66  TYR B CG  1 
ATOM   1365 C  CD1 . TYR B 1 30  ? 9.21779   -27.69445 17.79600  1.000 16.91507  ? 66  TYR B CD1 1 
ATOM   1366 C  CD2 . TYR B 1 30  ? 8.42328   -29.23558 16.14915  1.000 14.50240  ? 66  TYR B CD2 1 
ATOM   1367 C  CE1 . TYR B 1 30  ? 7.91341   -27.52623 18.29223  1.000 17.07030  ? 66  TYR B CE1 1 
ATOM   1368 C  CE2 . TYR B 1 30  ? 7.11447   -29.08045 16.63790  1.000 13.10062  ? 66  TYR B CE2 1 
ATOM   1369 C  CZ  . TYR B 1 30  ? 6.87738   -28.21356 17.69922  1.000 19.10190  ? 66  TYR B CZ  1 
ATOM   1370 O  OH  . TYR B 1 30  ? 5.59630   -28.05493 18.16844  1.000 19.19049  ? 66  TYR B OH  1 
ATOM   1371 N  N   . TYR B 1 31  ? 13.13168  -30.69623 15.24365  1.000 13.84542  ? 67  TYR B N   1 
ATOM   1372 C  CA  . TYR B 1 31  ? 14.33567  -30.94676 14.46651  1.000 15.04966  ? 67  TYR B CA  1 
ATOM   1373 C  C   . TYR B 1 31  ? 13.93561  -30.92947 13.00696  1.000 15.44463  ? 67  TYR B C   1 
ATOM   1374 O  O   . TYR B 1 31  ? 12.97022  -31.60097 12.63317  1.000 16.79237  ? 67  TYR B O   1 
ATOM   1375 C  CB  . TYR B 1 31  ? 14.94151  -32.30003 14.84483  1.000 19.30818  ? 67  TYR B CB  1 
ATOM   1376 C  CG  . TYR B 1 31  ? 16.04757  -32.80368 13.93485  1.000 22.08629  ? 67  TYR B CG  1 
ATOM   1377 C  CD1 . TYR B 1 31  ? 15.73641  -33.58170 12.82319  1.000 22.54128  ? 67  TYR B CD1 1 
ATOM   1378 C  CD2 . TYR B 1 31  ? 17.38946  -32.54976 14.20801  1.000 30.00105  ? 67  TYR B CD2 1 
ATOM   1379 C  CE1 . TYR B 1 31  ? 16.72666  -34.07637 11.98665  1.000 24.64693  ? 67  TYR B CE1 1 
ATOM   1380 C  CE2 . TYR B 1 31  ? 18.39726  -33.04995 13.35724  1.000 26.95535  ? 67  TYR B CE2 1 
ATOM   1381 C  CZ  . TYR B 1 31  ? 18.04251  -33.80808 12.25519  1.000 26.74869  ? 67  TYR B CZ  1 
ATOM   1382 O  OH  . TYR B 1 31  ? 18.99281  -34.32686 11.39563  1.000 33.23547  ? 67  TYR B OH  1 
ATOM   1383 N  N   . ILE B 1 32  ? 14.65865  -30.15958 12.19502  1.000 13.39629  ? 68  ILE B N   1 
ATOM   1384 C  CA  . ILE B 1 32  ? 14.48310  -30.15302 10.74561  1.000 13.05664  ? 68  ILE B CA  1 
ATOM   1385 C  C   . ILE B 1 32  ? 15.66473  -30.89630 10.13349  1.000 18.79443  ? 68  ILE B C   1 
ATOM   1386 O  O   . ILE B 1 32  ? 16.82420  -30.57062 10.42104  1.000 17.32712  ? 68  ILE B O   1 
ATOM   1387 C  CB  . ILE B 1 32  ? 14.37277  -28.71443 10.20121  1.000 13.63663  ? 68  ILE B CB  1 
ATOM   1388 C  CG1 . ILE B 1 32  ? 13.03878  -28.08687 10.65028  1.000 15.64721  ? 68  ILE B CG1 1 
ATOM   1389 C  CG2 . ILE B 1 32  ? 14.49628  -28.70478 8.66557   1.000 17.08248  ? 68  ILE B CG2 1 
ATOM   1390 C  CD1 . ILE B 1 32  ? 12.88500  -26.60102 10.27577  1.000 19.86264  ? 68  ILE B CD1 1 
ATOM   1391 N  N   . SER B 1 33  ? 15.37676  -31.88988 9.28406   1.000 13.15238  ? 69  SER B N   1 
ATOM   1392 C  CA  . SER B 1 33  ? 16.46345  -32.71668 8.77170   1.000 13.15682  ? 69  SER B CA  1 
ATOM   1393 C  C   . SER B 1 33  ? 17.32340  -31.92343 7.79807   1.000 14.92349  ? 69  SER B C   1 
ATOM   1394 O  O   . SER B 1 33  ? 16.88372  -30.93521 7.19515   1.000 17.87212  ? 69  SER B O   1 
ATOM   1395 C  CB  . SER B 1 33  ? 15.93909  -33.94595 8.03811   1.000 15.34599  ? 69  SER B CB  1 
ATOM   1396 O  OG  . SER B 1 33  ? 15.20487  -33.57489 6.87741   1.000 14.82723  ? 69  SER B OG  1 
ATOM   1397 N  N   . SER B 1 34  ? 18.55511  -32.39815 7.61893   1.000 14.83879  ? 70  SER B N   1 
ATOM   1398 C  CA  A SER B 1 34  ? 19.41117  -31.84630 6.57938   0.727 17.55018  ? 70  SER B CA  1 
ATOM   1399 C  CA  B SER B 1 34  ? 19.46562  -31.88430 6.60794   0.273 17.62409  ? 70  SER B CA  1 
ATOM   1400 C  C   . SER B 1 34  ? 19.49409  -32.74801 5.35567   1.000 18.49213  ? 70  SER B C   1 
ATOM   1401 O  O   . SER B 1 34  ? 20.15290  -32.37893 4.37942   1.000 20.20020  ? 70  SER B O   1 
ATOM   1402 C  CB  A SER B 1 34  ? 20.82192  -31.57915 7.12577   0.727 20.01079  ? 70  SER B CB  1 
ATOM   1403 C  CB  B SER B 1 34  ? 20.88595  -31.78053 7.18017   0.273 19.76540  ? 70  SER B CB  1 
ATOM   1404 O  OG  A SER B 1 34  ? 21.36726  -32.74421 7.70404   0.727 20.55916  ? 70  SER B OG  1 
ATOM   1405 O  OG  B SER B 1 34  ? 20.96483  -30.76606 8.16177   0.273 20.34543  ? 70  SER B OG  1 
ATOM   1406 N  N   . VAL B 1 35  ? 18.82190  -33.89870 5.37771   1.000 16.03102  ? 71  VAL B N   1 
ATOM   1407 C  CA  . VAL B 1 35  ? 18.71709  -34.78954 4.22598   1.000 15.18887  ? 71  VAL B CA  1 
ATOM   1408 C  C   . VAL B 1 35  ? 17.23990  -35.08821 3.97981   1.000 15.08064  ? 71  VAL B C   1 
ATOM   1409 O  O   . VAL B 1 35  ? 16.39829  -34.95853 4.87062   1.000 14.55027  ? 71  VAL B O   1 
ATOM   1410 C  CB  . VAL B 1 35  ? 19.48011  -36.11157 4.44252   1.000 16.95248  ? 71  VAL B CB  1 
ATOM   1411 C  CG1 . VAL B 1 35  ? 20.97325  -35.83875 4.64806   1.000 17.98434  ? 71  VAL B CG1 1 
ATOM   1412 C  CG2 . VAL B 1 35  ? 18.88084  -36.87851 5.63857   1.000 16.24108  ? 71  VAL B CG2 1 
ATOM   1413 N  N   . LYS B 1 36  ? 16.93077  -35.51220 2.75773   1.000 14.02757  ? 72  LYS B N   1 
ATOM   1414 C  CA  . LYS B 1 36  ? 15.59613  -36.03527 2.46212   1.000 14.25395  ? 72  LYS B CA  1 
ATOM   1415 C  C   . LYS B 1 36  ? 15.55984  -37.54455 2.68765   1.000 16.44543  ? 72  LYS B C   1 
ATOM   1416 O  O   . LYS B 1 36  ? 16.58426  -38.24104 2.62580   1.000 17.46857  ? 72  LYS B O   1 
ATOM   1417 C  CB  . LYS B 1 36  ? 15.20522  -35.72053 1.00748   1.000 14.59146  ? 72  LYS B CB  1 
ATOM   1418 C  CG  . LYS B 1 36  ? 15.19247  -34.23336 0.69871   1.000 14.29216  ? 72  LYS B CG  1 
ATOM   1419 C  CD  . LYS B 1 36  ? 14.48116  -33.97094 -0.61211  1.000 16.98306  ? 72  LYS B CD  1 
ATOM   1420 C  CE  . LYS B 1 36  ? 14.24939  -32.46870 -0.79679  1.000 20.71714  ? 72  LYS B CE  1 
ATOM   1421 N  NZ  . LYS B 1 36  ? 13.50981  -32.17861 -2.07576  1.000 19.98409  ? 72  LYS B NZ  1 
ATOM   1422 N  N   . ASN B 1 37  ? 14.36079  -38.06503 2.94477   1.000 16.77109  ? 73  ASN B N   1 
ATOM   1423 C  CA  . ASN B 1 37  ? 14.26294  -39.51037 3.06398   1.000 11.55019  ? 73  ASN B CA  1 
ATOM   1424 C  C   . ASN B 1 37  ? 12.81392  -39.93042 2.88132   1.000 15.51320  ? 73  ASN B C   1 
ATOM   1425 O  O   . ASN B 1 37  ? 11.90813  -39.08984 2.78205   1.000 13.69506  ? 73  ASN B O   1 
ATOM   1426 C  CB  . ASN B 1 37  ? 14.79487  -40.00323 4.40172   1.000 13.46122  ? 73  ASN B CB  1 
ATOM   1427 C  CG  . ASN B 1 37  ? 15.67537  -41.21272 4.23288   1.000 13.91388  ? 73  ASN B CG  1 
ATOM   1428 O  OD1 . ASN B 1 37  ? 15.45677  -42.01775 3.31369   1.000 17.69423  ? 73  ASN B OD1 1 
ATOM   1429 N  ND2 . ASN B 1 37  ? 16.67231  -41.34572 5.08679   1.000 15.43786  ? 73  ASN B ND2 1 
ATOM   1430 N  N   . THR B 1 38  ? 12.61811  -41.25141 2.80685   1.000 15.45501  ? 74  THR B N   1 
ATOM   1431 C  CA  . THR B 1 38  ? 11.27632  -41.80720 2.72763   1.000 14.54633  ? 74  THR B CA  1 
ATOM   1432 C  C   . THR B 1 38  ? 10.54979  -41.51942 4.03120   1.000 14.18043  ? 74  THR B C   1 
ATOM   1433 O  O   . THR B 1 38  ? 11.16765  -41.20852 5.05439   1.000 14.89684  ? 74  THR B O   1 
ATOM   1434 C  CB  . THR B 1 38  ? 11.30399  -43.32313 2.49369   1.000 15.59292  ? 74  THR B CB  1 
ATOM   1435 O  OG1 . THR B 1 38  ? 11.83903  -43.98082 3.65223   1.000 16.37634  ? 74  THR B OG1 1 
ATOM   1436 C  CG2 . THR B 1 38  ? 12.15235  -43.68986 1.27536   1.000 15.33189  ? 74  THR B CG2 1 
ATOM   1437 N  N   . TRP B 1 39  ? 9.22313   -41.63033 4.00091   1.000 13.17256  ? 75  TRP B N   1 
ATOM   1438 C  CA  . TRP B 1 39  ? 8.50163   -41.33641 5.23559   1.000 12.41161  ? 75  TRP B CA  1 
ATOM   1439 C  C   . TRP B 1 39  ? 8.95709   -42.28057 6.34343   1.000 14.71146  ? 75  TRP B C   1 
ATOM   1440 O  O   . TRP B 1 39  ? 9.20332   -41.85342 7.48251   1.000 14.48327  ? 75  TRP B O   1 
ATOM   1441 C  CB  . TRP B 1 39  ? 6.99050   -41.45065 4.99952   1.000 14.37194  ? 75  TRP B CB  1 
ATOM   1442 C  CG  . TRP B 1 39  ? 6.15033   -40.99435 6.17052   1.000 14.02908  ? 75  TRP B CG  1 
ATOM   1443 C  CD1 . TRP B 1 39  ? 5.61513   -39.73133 6.36557   1.000 14.58449  ? 75  TRP B CD1 1 
ATOM   1444 C  CD2 . TRP B 1 39  ? 5.73236   -41.78802 7.27823   1.000 14.45206  ? 75  TRP B CD2 1 
ATOM   1445 N  NE1 . TRP B 1 39  ? 4.88022   -39.70955 7.53531   1.000 16.92332  ? 75  TRP B NE1 1 
ATOM   1446 C  CE2 . TRP B 1 39  ? 4.93953   -40.95747 8.11733   1.000 14.79428  ? 75  TRP B CE2 1 
ATOM   1447 C  CE3 . TRP B 1 39  ? 5.93594   -43.13152 7.64431   1.000 17.11474  ? 75  TRP B CE3 1 
ATOM   1448 C  CZ2 . TRP B 1 39  ? 4.35924   -41.42789 9.30278   1.000 18.12293  ? 75  TRP B CZ2 1 
ATOM   1449 C  CZ3 . TRP B 1 39  ? 5.36180   -43.59832 8.82409   1.000 17.45376  ? 75  TRP B CZ3 1 
ATOM   1450 C  CH2 . TRP B 1 39  ? 4.58257   -42.74012 9.64801   1.000 18.06934  ? 75  TRP B CH2 1 
ATOM   1451 N  N   . HIS B 1 40  ? 9.15144   -43.56561 6.01301   1.000 13.64359  ? 76  HIS B N   1 
ATOM   1452 C  CA  . HIS B 1 40  ? 9.50444   -44.52969 7.05881   1.000 14.58329  ? 76  HIS B CA  1 
ATOM   1453 C  C   . HIS B 1 40  ? 10.92227  -44.31927 7.58615   1.000 14.92998  ? 76  HIS B C   1 
ATOM   1454 O  O   . HIS B 1 40  ? 11.15808  -44.42952 8.79407   1.000 16.75170  ? 76  HIS B O   1 
ATOM   1455 C  CB  . HIS B 1 40  ? 9.30378   -45.94128 6.51281   1.000 17.74709  ? 76  HIS B CB  1 
ATOM   1456 C  CG  . HIS B 1 40  ? 7.85360   -46.28648 6.36081   1.000 24.04547  ? 76  HIS B CG  1 
ATOM   1457 N  ND1 . HIS B 1 40  ? 7.16715   -46.08756 5.18202   1.000 25.53503  ? 76  HIS B ND1 1 
ATOM   1458 C  CD2 . HIS B 1 40  ? 6.94047   -46.73082 7.25790   1.000 29.76012  ? 76  HIS B CD2 1 
ATOM   1459 C  CE1 . HIS B 1 40  ? 5.90273   -46.43611 5.34692   1.000 28.50401  ? 76  HIS B CE1 1 
ATOM   1460 N  NE2 . HIS B 1 40  ? 5.73909   -46.82823 6.59807   1.000 30.26987  ? 76  HIS B NE2 1 
ATOM   1461 N  N   . LEU B 1 41  ? 11.86901  -43.99410 6.71183   1.000 16.92305  ? 77  LEU B N   1 
ATOM   1462 C  CA  . LEU B 1 41  ? 13.23551  -43.77627 7.17890   1.000 16.83302  ? 77  LEU B CA  1 
ATOM   1463 C  C   . LEU B 1 41  ? 13.37882  -42.42720 7.87449   1.000 16.79127  ? 77  LEU B C   1 
ATOM   1464 O  O   . LEU B 1 41  ? 14.21824  -42.28804 8.77152   1.000 14.43321  ? 77  LEU B O   1 
ATOM   1465 C  CB  . LEU B 1 41  ? 14.21103  -43.88110 5.99540   1.000 19.04401  ? 77  LEU B CB  1 
ATOM   1466 C  CG  . LEU B 1 41  ? 14.42345  -45.31655 5.49206   1.000 17.44335  ? 77  LEU B CG  1 
ATOM   1467 C  CD1 . LEU B 1 41  ? 15.31249  -45.33965 4.23614   1.000 20.22936  ? 77  LEU B CD1 1 
ATOM   1468 C  CD2 . LEU B 1 41  ? 15.03110  -46.16036 6.61747   1.000 27.13132  ? 77  LEU B CD2 1 
ATOM   1469 N  N   . SER B 1 42  ? 12.58522  -41.42866 7.46867   1.000 14.29359  ? 78  SER B N   1 
ATOM   1470 C  CA  . SER B 1 42  ? 12.49035  -40.19434 8.24772   1.000 16.25989  ? 78  SER B CA  1 
ATOM   1471 C  C   . SER B 1 42  ? 12.02253  -40.49681 9.65600   1.000 18.05420  ? 78  SER B C   1 
ATOM   1472 O  O   . SER B 1 42  ? 12.61598  -40.03943 10.64039  1.000 15.99818  ? 78  SER B O   1 
ATOM   1473 C  CB  . SER B 1 42  ? 11.51690  -39.20612 7.59431   1.000 12.92358  ? 78  SER B CB  1 
ATOM   1474 O  OG  . SER B 1 42  ? 11.95932  -38.86046 6.27473   1.000 14.67633  ? 78  SER B OG  1 
ATOM   1475 N  N   . ARG B 1 43  ? 10.94419  -41.26890 9.76943   1.000 16.17129  ? 79  ARG B N   1 
ATOM   1476 C  CA  . ARG B 1 43  ? 10.42622  -41.56307 11.09316  1.000 14.61347  ? 79  ARG B CA  1 
ATOM   1477 C  C   . ARG B 1 43  ? 11.45589  -42.33476 11.90111  1.000 17.61245  ? 79  ARG B C   1 
ATOM   1478 O  O   . ARG B 1 43  ? 11.63383  -42.08563 13.10174  1.000 18.26379  ? 79  ARG B O   1 
ATOM   1479 C  CB  . ARG B 1 43  ? 9.11421   -42.34423 10.98145  1.000 16.90190  ? 79  ARG B CB  1 
ATOM   1480 C  CG  . ARG B 1 43  ? 8.49577   -42.51504 12.35593  1.000 17.45561  ? 79  ARG B CG  1 
ATOM   1481 C  CD  . ARG B 1 43  ? 7.23821   -43.34893 12.34273  1.000 19.53188  ? 79  ARG B CD  1 
ATOM   1482 N  NE  . ARG B 1 43  ? 6.66938   -43.32535 13.68361  1.000 18.91647  ? 79  ARG B NE  1 
ATOM   1483 C  CZ  . ARG B 1 43  ? 5.80648   -44.22209 14.14037  1.000 33.30829  ? 79  ARG B CZ  1 
ATOM   1484 N  NH1 . ARG B 1 43  ? 5.34408   -45.19239 13.36536  1.000 36.96938  ? 79  ARG B NH1 1 
ATOM   1485 N  NH2 . ARG B 1 43  ? 5.39665   -44.14130 15.40199  1.000 28.61827  ? 79  ARG B NH2 1 
ATOM   1486 N  N   . GLU B 1 44  ? 12.18414  -43.23728 11.23799  1.000 18.94921  ? 80  GLU B N   1 
ATOM   1487 C  CA  . GLU B 1 44  ? 13.18500  -44.04147 11.93175  1.000 18.56382  ? 80  GLU B CA  1 
ATOM   1488 C  C   . GLU B 1 44  ? 14.22011  -43.15198 12.59486  1.000 19.27360  ? 80  GLU B C   1 
ATOM   1489 O  O   . GLU B 1 44  ? 14.62309  -43.39650 13.73817  1.000 18.23489  ? 80  GLU B O   1 
ATOM   1490 C  CB  . GLU B 1 44  ? 13.84992  -45.00175 10.94682  1.000 21.55523  ? 80  GLU B CB  1 
ATOM   1491 C  CG  . GLU B 1 44  ? 13.45936  -46.45007 11.17722  1.000 41.87969  ? 80  GLU B CG  1 
ATOM   1492 C  CD  . GLU B 1 44  ? 14.39637  -47.42583 10.48926  1.000 63.55160  ? 80  GLU B CD  1 
ATOM   1493 O  OE1 . GLU B 1 44  ? 15.61201  -47.39484 10.78564  1.000 70.00532  ? 80  GLU B OE1 1 
ATOM   1494 O  OE2 . GLU B 1 44  ? 13.91559  -48.22061 9.64848   1.000 69.83361  ? 80  GLU B OE2 1 
ATOM   1495 N  N   . TYR B 1 45  ? 14.62142  -42.08128 11.91108  1.000 18.62818  ? 81  TYR B N   1 
ATOM   1496 C  CA  . TYR B 1 45  ? 15.57819  -41.15643 12.49959  1.000 16.77772  ? 81  TYR B CA  1 
ATOM   1497 C  C   . TYR B 1 45  ? 14.99957  -40.52394 13.75864  1.000 18.42187  ? 81  TYR B C   1 
ATOM   1498 O  O   . TYR B 1 45  ? 15.64557  -40.51203 14.81485  1.000 18.44148  ? 81  TYR B O   1 
ATOM   1499 C  CB  . TYR B 1 45  ? 15.97634  -40.07339 11.48726  1.000 16.05830  ? 81  TYR B CB  1 
ATOM   1500 C  CG  . TYR B 1 45  ? 16.93365  -39.08175 12.10663  1.000 19.57932  ? 81  TYR B CG  1 
ATOM   1501 C  CD1 . TYR B 1 45  ? 16.46361  -37.97928 12.83576  1.000 16.66324  ? 81  TYR B CD1 1 
ATOM   1502 C  CD2 . TYR B 1 45  ? 18.30775  -39.26780 11.99954  1.000 20.83301  ? 81  TYR B CD2 1 
ATOM   1503 C  CE1 . TYR B 1 45  ? 17.34338  -37.08863 13.41926  1.000 17.11258  ? 81  TYR B CE1 1 
ATOM   1504 C  CE2 . TYR B 1 45  ? 19.18740  -38.38114 12.58871  1.000 20.62833  ? 81  TYR B CE2 1 
ATOM   1505 C  CZ  . TYR B 1 45  ? 18.69522  -37.29584 13.29062  1.000 16.71601  ? 81  TYR B CZ  1 
ATOM   1506 O  OH  . TYR B 1 45  ? 19.56579  -36.40653 13.89437  1.000 22.73789  ? 81  TYR B OH  1 
ATOM   1507 N  N   . CYS B 1 46  ? 13.78611  -39.96475 13.65282  1.000 17.91134  ? 82  CYS B N   1 
ATOM   1508 C  CA  . CYS B 1 46  ? 13.14226  -39.36289 14.81513  1.000 15.46341  ? 82  CYS B CA  1 
ATOM   1509 C  C   . CYS B 1 46  ? 13.04531  -40.36352 15.96580  1.000 21.14079  ? 82  CYS B C   1 
ATOM   1510 O  O   . CYS B 1 46  ? 13.31868  -40.01992 17.12246  1.000 18.69040  ? 82  CYS B O   1 
ATOM   1511 C  CB  . CYS B 1 46  ? 11.73992  -38.86692 14.44931  1.000 16.53370  ? 82  CYS B CB  1 
ATOM   1512 S  SG  . CYS B 1 46  ? 11.73542  -37.63658 13.12238  1.000 18.06764  ? 82  CYS B SG  1 
ATOM   1513 N  N   . LEU B 1 47  ? 12.66125  -41.61014 15.65847  1.000 17.90786  ? 83  LEU B N   1 
ATOM   1514 C  CA  . LEU B 1 47  ? 12.47849  -42.62359 16.69647  1.000 16.77620  ? 83  LEU B CA  1 
ATOM   1515 C  C   . LEU B 1 47  ? 13.79759  -42.95350 17.36811  1.000 21.87564  ? 83  LEU B C   1 
ATOM   1516 O  O   . LEU B 1 47  ? 13.83636  -43.17526 18.58803  1.000 25.24808  ? 83  LEU B O   1 
ATOM   1517 C  CB  . LEU B 1 47  ? 11.86576  -43.89431 16.09384  1.000 19.80662  ? 83  LEU B CB  1 
ATOM   1518 C  CG  . LEU B 1 47  ? 10.40830  -43.79636 15.62217  1.000 18.37098  ? 83  LEU B CG  1 
ATOM   1519 C  CD1 . LEU B 1 47  ? 9.97924   -45.05615 14.82237  1.000 18.04444  ? 83  LEU B CD1 1 
ATOM   1520 C  CD2 . LEU B 1 47  ? 9.46715   -43.55113 16.79878  1.000 24.25928  ? 83  LEU B CD2 1 
ATOM   1521 N  N   . GLN B 1 48  ? 14.89107  -42.98779 16.59248  1.000 20.35085  ? 84  GLN B N   1 
ATOM   1522 C  CA  . GLN B 1 48  ? 16.18787  -43.30665 17.19173  1.000 29.33308  ? 84  GLN B CA  1 
ATOM   1523 C  C   . GLN B 1 48  ? 16.67377  -42.19459 18.10781  1.000 32.72489  ? 84  GLN B C   1 
ATOM   1524 O  O   . GLN B 1 48  ? 17.53388  -42.44291 18.96131  1.000 25.35283  ? 84  GLN B O   1 
ATOM   1525 C  CB  . GLN B 1 48  ? 17.26269  -43.59840 16.12826  1.000 27.59084  ? 84  GLN B CB  1 
ATOM   1526 C  CG  . GLN B 1 48  ? 18.01280  -42.38397 15.56056  1.000 47.99461  ? 84  GLN B CG  1 
ATOM   1527 C  CD  . GLN B 1 48  ? 19.27656  -42.77037 14.76460  1.000 62.59853  ? 84  GLN B CD  1 
ATOM   1528 O  OE1 . GLN B 1 48  ? 19.30931  -42.71433 13.52680  1.000 44.30777  ? 84  GLN B OE1 1 
ATOM   1529 N  NE2 . GLN B 1 48  ? 20.32072  -43.17427 15.48838  1.000 66.61950  ? 84  GLN B NE2 1 
ATOM   1530 N  N   . GLU B 1 49  ? 16.14534  -40.98079 17.95141  1.000 23.30535  ? 85  GLU B N   1 
ATOM   1531 C  CA  . GLU B 1 49  ? 16.41691  -39.87795 18.86178  1.000 20.28447  ? 85  GLU B CA  1 
ATOM   1532 C  C   . GLU B 1 49  ? 15.45110  -39.85082 20.03868  1.000 24.95887  ? 85  GLU B C   1 
ATOM   1533 O  O   . GLU B 1 49  ? 15.46362  -38.88931 20.81772  1.000 30.66936  ? 85  GLU B O   1 
ATOM   1534 C  CB  . GLU B 1 49  ? 16.35500  -38.53830 18.10212  1.000 22.84757  ? 85  GLU B CB  1 
ATOM   1535 C  CG  . GLU B 1 49  ? 17.40481  -38.38643 17.00905  1.000 23.56028  ? 85  GLU B CG  1 
ATOM   1536 C  CD  . GLU B 1 49  ? 18.82658  -38.55354 17.51953  1.000 33.87401  ? 85  GLU B CD  1 
ATOM   1537 O  OE1 . GLU B 1 49  ? 19.19825  -37.88668 18.50722  1.000 38.70792  ? 85  GLU B OE1 1 
ATOM   1538 O  OE2 . GLU B 1 49  ? 19.57672  -39.35941 16.93426  1.000 43.50660  ? 85  GLU B OE2 1 
ATOM   1539 N  N   . GLY B 1 50  ? 14.61634  -40.88016 20.18671  1.000 22.50898  ? 86  GLY B N   1 
ATOM   1540 C  CA  . GLY B 1 50  ? 13.62908  -40.90184 21.25387  1.000 23.85534  ? 86  GLY B CA  1 
ATOM   1541 C  C   . GLY B 1 50  ? 12.45649  -39.98417 21.01423  1.000 31.42861  ? 86  GLY B C   1 
ATOM   1542 O  O   . GLY B 1 50  ? 11.78839  -39.57554 21.97297  1.000 25.14705  ? 86  GLY B O   1 
ATOM   1543 N  N   . ALA B 1 51  ? 12.19627  -39.63493 19.75854  1.000 21.07956  ? 87  ALA B N   1 
ATOM   1544 C  CA  . ALA B 1 51  ? 11.13782  -38.69198 19.41688  1.000 18.86545  ? 87  ALA B CA  1 
ATOM   1545 C  C   . ALA B 1 51  ? 10.25715  -39.36510 18.36929  1.000 17.01246  ? 87  ALA B C   1 
ATOM   1546 O  O   . ALA B 1 51  ? 10.20776  -40.59825 18.25837  1.000 18.70781  ? 87  ALA B O   1 
ATOM   1547 C  CB  . ALA B 1 51  ? 11.73443  -37.37535 18.91414  1.000 17.91433  ? 87  ALA B CB  1 
ATOM   1548 N  N   . ASP B 1 52  ? 9.56618   -38.55447 17.56798  1.000 17.22775  ? 88  ASP B N   1 
ATOM   1549 C  CA  . ASP B 1 52  ? 8.77653   -39.08904 16.46249  1.000 20.53185  ? 88  ASP B CA  1 
ATOM   1550 C  C   . ASP B 1 52  ? 8.57108   -37.95828 15.45837  1.000 16.12897  ? 88  ASP B C   1 
ATOM   1551 O  O   . ASP B 1 52  ? 9.04603   -36.83756 15.65823  1.000 16.64247  ? 88  ASP B O   1 
ATOM   1552 C  CB  . ASP B 1 52  ? 7.45198   -39.67949 16.97128  1.000 19.13959  ? 88  ASP B CB  1 
ATOM   1553 C  CG  . ASP B 1 52  ? 6.95776   -40.85976 16.12641  1.000 18.50808  ? 88  ASP B CG  1 
ATOM   1554 O  OD1 . ASP B 1 52  ? 7.21658   -40.88703 14.89941  1.000 18.20576  ? 88  ASP B OD1 1 
ATOM   1555 O  OD2 . ASP B 1 52  ? 6.25838   -41.74550 16.68184  1.000 19.14303  ? 88  ASP B OD2 1 
ATOM   1556 N  N   . LEU B 1 53  ? 7.90322   -38.26594 14.34776  1.000 15.71407  ? 89  LEU B N   1 
ATOM   1557 C  CA  . LEU B 1 53  ? 7.62089   -37.20826 13.38352  1.000 16.13010  ? 89  LEU B CA  1 
ATOM   1558 C  C   . LEU B 1 53  ? 6.65023   -36.20727 14.00188  1.000 14.47123  ? 89  LEU B C   1 
ATOM   1559 O  O   . LEU B 1 53  ? 5.92866   -36.52573 14.95037  1.000 14.60707  ? 89  LEU B O   1 
ATOM   1560 C  CB  . LEU B 1 53  ? 7.03283   -37.79550 12.09952  1.000 13.79108  ? 89  LEU B CB  1 
ATOM   1561 C  CG  . LEU B 1 53  ? 8.03845   -38.48726 11.18721  1.000 14.24191  ? 89  LEU B CG  1 
ATOM   1562 C  CD1 . LEU B 1 53  ? 7.26575   -39.22055 10.11220  1.000 15.64239  ? 89  LEU B CD1 1 
ATOM   1563 C  CD2 . LEU B 1 53  ? 8.98846   -37.44797 10.53292  1.000 17.25017  ? 89  LEU B CD2 1 
ATOM   1564 N  N   . ALA B 1 54  ? 6.62768   -34.98946 13.45507  1.000 13.58724  ? 90  ALA B N   1 
ATOM   1565 C  CA  . ALA B 1 54  ? 5.88282   -33.91017 14.10301  1.000 15.71188  ? 90  ALA B CA  1 
ATOM   1566 C  C   . ALA B 1 54  ? 4.38271   -34.20970 14.13802  1.000 18.24430  ? 90  ALA B C   1 
ATOM   1567 O  O   . ALA B 1 54  ? 3.81569   -34.74632 13.18502  1.000 17.01939  ? 90  ALA B O   1 
ATOM   1568 C  CB  . ALA B 1 54  ? 6.13490   -32.57663 13.39022  1.000 15.63965  ? 90  ALA B CB  1 
ATOM   1569 N  N   . ILE B 1 55  ? 3.73605   -33.85506 15.24901  1.000 15.50525  ? 91  ILE B N   1 
ATOM   1570 C  CA  . ILE B 1 55  ? 2.28766   -34.00123 15.39496  1.000 15.53086  ? 91  ILE B CA  1 
ATOM   1571 C  C   . ILE B 1 55  ? 1.67447   -32.61066 15.53300  1.000 15.30613  ? 91  ILE B C   1 
ATOM   1572 O  O   . ILE B 1 55  ? 2.06636   -31.83096 16.40873  1.000 13.81532  ? 91  ILE B O   1 
ATOM   1573 C  CB  . ILE B 1 55  ? 1.94088   -34.89403 16.59543  1.000 15.09369  ? 91  ILE B CB  1 
ATOM   1574 C  CG1 . ILE B 1 55  ? 2.46951   -36.30896 16.37250  1.000 14.02874  ? 91  ILE B CG1 1 
ATOM   1575 C  CG2 . ILE B 1 55  ? 0.42594   -34.87099 16.89682  1.000 16.38674  ? 91  ILE B CG2 1 
ATOM   1576 C  CD1 . ILE B 1 55  ? 2.56512   -37.11257 17.69175  1.000 22.40788  ? 91  ILE B CD1 1 
ATOM   1577 N  N   . ILE B 1 56  ? 0.73953   -32.26811 14.65541  1.000 15.30231  ? 92  ILE B N   1 
ATOM   1578 C  CA  . ILE B 1 56  ? 0.18506   -30.91643 14.64766  1.000 16.39313  ? 92  ILE B CA  1 
ATOM   1579 C  C   . ILE B 1 56  ? -1.07216  -30.89679 15.51673  1.000 20.13889  ? 92  ILE B C   1 
ATOM   1580 O  O   . ILE B 1 56  ? -2.09600  -31.48549 15.16183  1.000 22.84658  ? 92  ILE B O   1 
ATOM   1581 C  CB  . ILE B 1 56  ? -0.09128  -30.44011 13.21798  1.000 17.43726  ? 92  ILE B CB  1 
ATOM   1582 C  CG1 . ILE B 1 56  ? 1.18452   -30.60215 12.38530  1.000 20.48778  ? 92  ILE B CG1 1 
ATOM   1583 C  CG2 . ILE B 1 56  ? -0.56627  -28.98407 13.22232  1.000 18.46535  ? 92  ILE B CG2 1 
ATOM   1584 C  CD1 . ILE B 1 56  ? 2.38397   -29.85830 12.95937  1.000 18.03562  ? 92  ILE B CD1 1 
ATOM   1585 N  N   . ASN B 1 57  ? -0.98809  -30.20692 16.66433  1.000 18.05471  ? 93  ASN B N   1 
ATOM   1586 C  CA  . ASN B 1 57  ? -2.03562  -30.19795 17.68904  1.000 21.69573  ? 93  ASN B CA  1 
ATOM   1587 C  C   . ASN B 1 57  ? -2.85233  -28.91537 17.73188  1.000 26.11158  ? 93  ASN B C   1 
ATOM   1588 O  O   . ASN B 1 57  ? -3.83602  -28.84935 18.48376  1.000 27.35624  ? 93  ASN B O   1 
ATOM   1589 C  CB  . ASN B 1 57  ? -1.41406  -30.41869 19.07378  1.000 23.79399  ? 93  ASN B CB  1 
ATOM   1590 C  CG  . ASN B 1 57  ? -0.64960  -31.70616 19.14839  1.000 22.83786  ? 93  ASN B CG  1 
ATOM   1591 O  OD1 . ASN B 1 57  ? 0.56336   -31.72867 18.94461  1.000 19.25812  ? 93  ASN B OD1 1 
ATOM   1592 N  ND2 . ASN B 1 57  ? -1.35703  -32.79953 19.38907  1.000 25.47273  ? 93  ASN B ND2 1 
ATOM   1593 N  N   . SER B 1 58  ? -2.47572  -27.89397 16.97215  1.000 18.20437  ? 94  SER B N   1 
ATOM   1594 C  CA  . SER B 1 58  ? -3.15019  -26.61314 17.10229  1.000 21.06320  ? 94  SER B CA  1 
ATOM   1595 C  C   . SER B 1 58  ? -2.90997  -25.79979 15.84661  1.000 23.76847  ? 94  SER B C   1 
ATOM   1596 O  O   . SER B 1 58  ? -1.96719  -26.05449 15.08785  1.000 18.36127  ? 94  SER B O   1 
ATOM   1597 C  CB  . SER B 1 58  ? -2.67255  -25.85175 18.34911  1.000 22.24110  ? 94  SER B CB  1 
ATOM   1598 O  OG  . SER B 1 58  ? -1.30731  -25.46534 18.22941  1.000 23.45945  ? 94  SER B OG  1 
ATOM   1599 N  N   . ARG B 1 59  ? -3.77818  -24.80367 15.64838  1.000 20.22341  ? 95  ARG B N   1 
ATOM   1600 C  CA  . ARG B 1 59  ? -3.61559  -23.89159 14.52464  1.000 20.26998  ? 95  ARG B CA  1 
ATOM   1601 C  C   . ARG B 1 59  ? -2.28459  -23.15886 14.61479  1.000 20.94573  ? 95  ARG B C   1 
ATOM   1602 O  O   . ARG B 1 59  ? -1.62708  -22.92246 13.59524  1.000 20.99129  ? 95  ARG B O   1 
ATOM   1603 C  CB  . ARG B 1 59  ? -4.77823  -22.89354 14.49239  1.000 29.00025  ? 95  ARG B CB  1 
ATOM   1604 C  CG  . ARG B 1 59  ? -4.88653  -22.09465 13.19326  1.000 31.09225  ? 95  ARG B CG  1 
ATOM   1605 C  CD  . ARG B 1 59  ? -6.20879  -21.32123 13.11170  1.000 43.34465  ? 95  ARG B CD  1 
ATOM   1606 N  NE  . ARG B 1 59  ? -6.00439  -19.90630 12.82171  1.000 73.89555  ? 95  ARG B NE  1 
ATOM   1607 C  CZ  . ARG B 1 59  ? -6.79762  -18.92579 13.23735  1.000 82.88826  ? 95  ARG B CZ  1 
ATOM   1608 N  NH1 . ARG B 1 59  ? -7.86732  -19.16650 13.98052  1.000 78.81664  ? 95  ARG B NH1 1 
ATOM   1609 N  NH2 . ARG B 1 59  ? -6.51035  -17.67094 12.89862  1.000 81.41738  ? 95  ARG B NH2 1 
ATOM   1610 N  N   . ALA B 1 60  ? -1.87060  -22.79739 15.83112  1.000 22.30858  ? 96  ALA B N   1 
ATOM   1611 C  CA  . ALA B 1 60  ? -0.60127  -22.10203 15.99781  1.000 23.35312  ? 96  ALA B CA  1 
ATOM   1612 C  C   . ALA B 1 60  ? 0.55922   -22.98990 15.58429  1.000 20.25835  ? 96  ALA B C   1 
ATOM   1613 O  O   . ALA B 1 60  ? 1.54200   -22.51314 14.99949  1.000 17.84249  ? 96  ALA B O   1 
ATOM   1614 C  CB  . ALA B 1 60  ? -0.42685  -21.65340 17.44670  1.000 25.61174  ? 96  ALA B CB  1 
ATOM   1615 N  N   . GLU B 1 61  ? 0.46923   -24.28745 15.88888  1.000 17.67741  ? 97  GLU B N   1 
ATOM   1616 C  CA  . GLU B 1 61  ? 1.55220   -25.18543 15.49194  1.000 18.55600  ? 97  GLU B CA  1 
ATOM   1617 C  C   . GLU B 1 61  ? 1.57803   -25.38002 13.97729  1.000 16.31188  ? 97  GLU B C   1 
ATOM   1618 O  O   . GLU B 1 61  ? 2.66159   -25.49990 13.38377  1.000 15.66276  ? 97  GLU B O   1 
ATOM   1619 C  CB  . GLU B 1 61  ? 1.43007   -26.52543 16.22232  1.000 17.71333  ? 97  GLU B CB  1 
ATOM   1620 C  CG  . GLU B 1 61  ? 2.71744   -27.37557 16.15814  1.000 16.90599  ? 97  GLU B CG  1 
ATOM   1621 C  CD  . GLU B 1 61  ? 2.62236   -28.65136 16.98353  1.000 16.93279  ? 97  GLU B CD  1 
ATOM   1622 O  OE1 . GLU B 1 61  ? 1.49652   -29.01720 17.41321  1.000 19.10796  ? 97  GLU B OE1 1 
ATOM   1623 O  OE2 . GLU B 1 61  ? 3.67493   -29.26865 17.23317  1.000 18.18165  ? 97  GLU B OE2 1 
ATOM   1624 N  N   . GLN B 1 62  ? 0.40087   -25.41194 13.33331  1.000 14.03261  ? 98  GLN B N   1 
ATOM   1625 C  CA  . GLN B 1 62  ? 0.37084   -25.48748 11.87377  1.000 16.24799  ? 98  GLN B CA  1 
ATOM   1626 C  C   . GLN B 1 62  ? 0.95892   -24.22392 11.24792  1.000 17.81550  ? 98  GLN B C   1 
ATOM   1627 O  O   . GLN B 1 62  ? 1.69844   -24.29422 10.25892  1.000 16.46493  ? 98  GLN B O   1 
ATOM   1628 C  CB  . GLN B 1 62  ? -1.06026  -25.71835 11.38604  1.000 14.62578  ? 98  GLN B CB  1 
ATOM   1629 C  CG  . GLN B 1 62  ? -1.17757  -25.68247 9.85540   1.000 14.45948  ? 98  GLN B CG  1 
ATOM   1630 C  CD  . GLN B 1 62  ? -0.54568  -26.92367 9.20723   1.000 15.94455  ? 98  GLN B CD  1 
ATOM   1631 O  OE1 . GLN B 1 62  ? -0.34870  -27.94710 9.86045   1.000 15.76283  ? 98  GLN B OE1 1 
ATOM   1632 N  NE2 . GLN B 1 62  ? -0.26541  -26.83434 7.91036   1.000 15.53970  ? 98  GLN B NE2 1 
ATOM   1633 N  N   . ALA B 1 63  ? 0.64486   -23.05245 11.80735  1.000 15.46489  ? 99  ALA B N   1 
ATOM   1634 C  CA  . ALA B 1 63  ? 1.23569   -21.81679 11.29108  1.000 16.43349  ? 99  ALA B CA  1 
ATOM   1635 C  C   . ALA B 1 63  ? 2.75704   -21.82490 11.43290  1.000 16.87264  ? 99  ALA B C   1 
ATOM   1636 O  O   . ALA B 1 63  ? 3.48410   -21.37033 10.53748  1.000 18.35772  ? 99  ALA B O   1 
ATOM   1637 C  CB  . ALA B 1 63  ? 0.63038   -20.61505 12.02878  1.000 20.24689  ? 99  ALA B CB  1 
ATOM   1638 N  N   . PHE B 1 64  ? 3.25055   -22.35107 12.55406  1.000 15.64222  ? 100 PHE B N   1 
ATOM   1639 C  CA  . PHE B 1 64  ? 4.68647   -22.46924 12.79611  1.000 16.05875  ? 100 PHE B CA  1 
ATOM   1640 C  C   . PHE B 1 64  ? 5.32597   -23.38742 11.75820  1.000 20.39579  ? 100 PHE B C   1 
ATOM   1641 O  O   . PHE B 1 64  ? 6.32350   -23.02885 11.11059  1.000 15.82062  ? 100 PHE B O   1 
ATOM   1642 C  CB  . PHE B 1 64  ? 4.84847   -22.96512 14.25112  1.000 15.34738  ? 100 PHE B CB  1 
ATOM   1643 C  CG  . PHE B 1 64  ? 6.18834   -23.57310 14.62046  1.000 16.16564  ? 100 PHE B CG  1 
ATOM   1644 C  CD1 . PHE B 1 64  ? 7.27024   -22.75890 14.97713  1.000 18.13298  ? 100 PHE B CD1 1 
ATOM   1645 C  CD2 . PHE B 1 64  ? 6.31816   -24.95873 14.74214  1.000 16.31123  ? 100 PHE B CD2 1 
ATOM   1646 C  CE1 . PHE B 1 64  ? 8.48318   -23.32984 15.39742  1.000 19.38355  ? 100 PHE B CE1 1 
ATOM   1647 C  CE2 . PHE B 1 64  ? 7.51570   -25.54862 15.15640  1.000 19.45092  ? 100 PHE B CE2 1 
ATOM   1648 C  CZ  . PHE B 1 64  ? 8.60866   -24.72398 15.48626  1.000 18.97687  ? 100 PHE B CZ  1 
ATOM   1649 N  N   . LEU B 1 65  ? 4.70549   -24.54891 11.52397  1.000 16.57708  ? 101 LEU B N   1 
ATOM   1650 C  CA  . LEU B 1 65  ? 5.18373   -25.45617 10.48623  1.000 17.63031  ? 101 LEU B CA  1 
ATOM   1651 C  C   . LEU B 1 65  ? 5.23784   -24.76088 9.12818   1.000 14.56105  ? 101 LEU B C   1 
ATOM   1652 O  O   . LEU B 1 65  ? 6.23596   -24.86442 8.40567   1.000 16.27611  ? 101 LEU B O   1 
ATOM   1653 C  CB  . LEU B 1 65  ? 4.27314   -26.69765 10.43976  1.000 12.83790  ? 101 LEU B CB  1 
ATOM   1654 C  CG  . LEU B 1 65  ? 4.39987   -27.64612 9.23663   1.000 14.42962  ? 101 LEU B CG  1 
ATOM   1655 C  CD1 . LEU B 1 65  ? 5.73404   -28.32928 9.25323   1.000 16.48935  ? 101 LEU B CD1 1 
ATOM   1656 C  CD2 . LEU B 1 65  ? 3.28447   -28.70113 9.34234   1.000 16.58211  ? 101 LEU B CD2 1 
ATOM   1657 N  N   . GLU B 1 66  ? 4.16225   -24.04809 8.76261   1.000 14.15456  ? 102 GLU B N   1 
ATOM   1658 C  CA  . GLU B 1 66  ? 4.07417   -23.45893 7.42516   1.000 14.29097  ? 102 GLU B CA  1 
ATOM   1659 C  C   . GLU B 1 66  ? 5.11435   -22.36749 7.22811   1.000 16.73372  ? 102 GLU B C   1 
ATOM   1660 O  O   . GLU B 1 66  ? 5.62593   -22.18262 6.11590   1.000 16.18129  ? 102 GLU B O   1 
ATOM   1661 C  CB  . GLU B 1 66  ? 2.66936   -22.88362 7.21484   1.000 20.61661  ? 102 GLU B CB  1 
ATOM   1662 C  CG  . GLU B 1 66  ? 1.58320   -23.93836 7.29092   1.000 37.50517  ? 102 GLU B CG  1 
ATOM   1663 C  CD  . GLU B 1 66  ? 0.32894   -23.55320 6.51149   1.000 55.98058  ? 102 GLU B CD  1 
ATOM   1664 O  OE1 . GLU B 1 66  ? -0.38579  -24.47708 6.03981   1.000 50.96183  ? 102 GLU B OE1 1 
ATOM   1665 O  OE2 . GLU B 1 66  ? 0.06775   -22.32338 6.40271   1.000 32.72777  ? 102 GLU B OE2 1 
ATOM   1666 N  N   . ASN B 1 67  ? 5.45562   -21.66060 8.30467   1.000 15.59802  ? 103 ASN B N   1 
ATOM   1667 C  CA  . ASN B 1 67  ? 6.33424   -20.51586 8.17333   1.000 15.17557  ? 103 ASN B CA  1 
ATOM   1668 C  C   . ASN B 1 67  ? 7.77590   -20.91214 7.87903   1.000 14.93574  ? 103 ASN B C   1 
ATOM   1669 O  O   . ASN B 1 67  ? 8.58039   -20.04862 7.51690   1.000 16.54603  ? 103 ASN B O   1 
ATOM   1670 C  CB  . ASN B 1 67  ? 6.23844   -19.66845 9.44425   1.000 14.89696  ? 103 ASN B CB  1 
ATOM   1671 C  CG  . ASN B 1 67  ? 6.91112   -18.32268 9.27691   1.000 16.02916  ? 103 ASN B CG  1 
ATOM   1672 O  OD1 . ASN B 1 67  ? 6.66125   -17.59853 8.28281   1.000 17.66107  ? 103 ASN B OD1 1 
ATOM   1673 N  ND2 . ASN B 1 67  ? 7.79117   -17.99283 10.21182  1.000 14.70107  ? 103 ASN B ND2 1 
ATOM   1674 N  N   . PHE B 1 68  ? 8.12497   -22.19053 7.99765   1.000 14.58365  ? 104 PHE B N   1 
ATOM   1675 C  CA  . PHE B 1 68  ? 9.46405   -22.58399 7.58999   1.000 13.16680  ? 104 PHE B CA  1 
ATOM   1676 C  C   . PHE B 1 68  ? 9.58367   -22.67430 6.07649   1.000 13.58833  ? 104 PHE B C   1 
ATOM   1677 O  O   . PHE B 1 68  ? 10.69050  -22.87308 5.58600   1.000 14.49898  ? 104 PHE B O   1 
ATOM   1678 C  CB  . PHE B 1 68  ? 9.83139   -23.91320 8.25710   1.000 13.88665  ? 104 PHE B CB  1 
ATOM   1679 C  CG  . PHE B 1 68  ? 10.05227  -23.76594 9.73401   1.000 13.73298  ? 104 PHE B CG  1 
ATOM   1680 C  CD1 . PHE B 1 68  ? 11.01294  -22.87250 10.19052  1.000 14.40570  ? 104 PHE B CD1 1 
ATOM   1681 C  CD2 . PHE B 1 68  ? 9.24215   -24.42604 10.65622  1.000 16.67131  ? 104 PHE B CD2 1 
ATOM   1682 C  CE1 . PHE B 1 68  ? 11.21460  -22.68459 11.56041  1.000 16.21012  ? 104 PHE B CE1 1 
ATOM   1683 C  CE2 . PHE B 1 68  ? 9.43378   -24.24436 12.01971  1.000 16.87844  ? 104 PHE B CE2 1 
ATOM   1684 C  CZ  . PHE B 1 68  ? 10.41898  -23.37416 12.47405  1.000 18.24866  ? 104 PHE B CZ  1 
ATOM   1685 N  N   . LYS B 1 69  ? 8.46468   -22.52976 5.34266   1.000 14.13873  ? 105 LYS B N   1 
ATOM   1686 C  CA  . LYS B 1 69  ? 8.49861   -22.44911 3.87615   1.000 14.27616  ? 105 LYS B CA  1 
ATOM   1687 C  C   . LYS B 1 69  ? 9.22168   -23.65608 3.27784   1.000 17.33583  ? 105 LYS B C   1 
ATOM   1688 O  O   . LYS B 1 69  ? 10.07021  -23.53624 2.38854   1.000 15.93136  ? 105 LYS B O   1 
ATOM   1689 C  CB  . LYS B 1 69  ? 9.14896   -21.13056 3.43238   1.000 18.19373  ? 105 LYS B CB  1 
ATOM   1690 C  CG  . LYS B 1 69  ? 8.54945   -19.92047 4.13296   1.000 25.05691  ? 105 LYS B CG  1 
ATOM   1691 C  CD  . LYS B 1 69  ? 9.21018   -18.60223 3.66954   1.000 23.65319  ? 105 LYS B CD  1 
ATOM   1692 C  CE  . LYS B 1 69  ? 9.46443   -17.65946 4.85700   1.000 19.92130  ? 105 LYS B CE  1 
ATOM   1693 N  NZ  . LYS B 1 69  ? 8.33324   -17.69594 5.84060   1.000 16.24147  ? 105 LYS B NZ  1 
ATOM   1694 N  N   . MET B 1 70  ? 8.86944   -24.83860 3.78043   1.000 12.75692  ? 106 MET B N   1 
ATOM   1695 C  CA  . MET B 1 70  ? 9.60904   -26.07214 3.53620   1.000 16.42927  ? 106 MET B CA  1 
ATOM   1696 C  C   . MET B 1 70  ? 8.64485   -27.22885 3.33843   1.000 14.13269  ? 106 MET B C   1 
ATOM   1697 O  O   . MET B 1 70  ? 7.73838   -27.41334 4.15003   1.000 16.63525  ? 106 MET B O   1 
ATOM   1698 C  CB  . MET B 1 70  ? 10.48245  -26.46313 4.73580   1.000 18.77665  ? 106 MET B CB  1 
ATOM   1699 C  CG  . MET B 1 70  ? 11.60122  -27.39039 4.37986   1.000 20.68750  ? 106 MET B CG  1 
ATOM   1700 S  SD  . MET B 1 70  ? 12.70386  -27.53945 5.80243   1.000 23.05699  ? 106 MET B SD  1 
ATOM   1701 C  CE  . MET B 1 70  ? 13.54029  -25.93553 5.80080   1.000 19.68173  ? 106 MET B CE  1 
ATOM   1702 N  N   . THR B 1 71  ? 8.84035   -28.02770 2.29605   1.000 15.07341  ? 107 THR B N   1 
ATOM   1703 C  CA  . THR B 1 71  ? 8.04248   -29.24432 2.17390   1.000 13.83150  ? 107 THR B CA  1 
ATOM   1704 C  C   . THR B 1 71  ? 8.60083   -30.30050 3.11847   1.000 13.73464  ? 107 THR B C   1 
ATOM   1705 O  O   . THR B 1 71  ? 9.78268   -30.65224 3.03543   1.000 15.59024  ? 107 THR B O   1 
ATOM   1706 C  CB  . THR B 1 71  ? 8.05513   -29.74284 0.73396   1.000 18.17673  ? 107 THR B CB  1 
ATOM   1707 O  OG1 . THR B 1 71  ? 7.41986   -28.75199 -0.07384  1.000 16.01111  ? 107 THR B OG1 1 
ATOM   1708 C  CG2 . THR B 1 71  ? 7.26024   -31.06351 0.61412   1.000 18.20667  ? 107 THR B CG2 1 
ATOM   1709 N  N   . LEU B 1 72  ? 7.74538   -30.81660 4.01045   1.000 12.15765  ? 108 LEU B N   1 
ATOM   1710 C  CA  . LEU B 1 72  ? 8.21347   -31.64939 5.10882   1.000 10.35434  ? 108 LEU B CA  1 
ATOM   1711 C  C   . LEU B 1 72  ? 7.29177   -32.82943 5.34543   1.000 13.81807  ? 108 LEU B C   1 
ATOM   1712 O  O   . LEU B 1 72  ? 6.07703   -32.64308 5.46027   1.000 14.75224  ? 108 LEU B O   1 
ATOM   1713 C  CB  . LEU B 1 72  ? 8.25414   -30.86710 6.44222   1.000 12.00610  ? 108 LEU B CB  1 
ATOM   1714 C  CG  . LEU B 1 72  ? 9.36563   -29.82285 6.58884   1.000 12.28531  ? 108 LEU B CG  1 
ATOM   1715 C  CD1 . LEU B 1 72  ? 8.94943   -28.78214 7.63031   1.000 13.87078  ? 108 LEU B CD1 1 
ATOM   1716 C  CD2 . LEU B 1 72  ? 10.66278  -30.55364 7.01114   1.000 12.20974  ? 108 LEU B CD2 1 
ATOM   1717 N  N   . TRP B 1 73  ? 7.87120   -34.02164 5.52919   1.000 13.84810  ? 109 TRP B N   1 
ATOM   1718 C  CA  . TRP B 1 73  ? 7.08601   -35.11563 6.10479   1.000 13.24080  ? 109 TRP B CA  1 
ATOM   1719 C  C   . TRP B 1 73  ? 6.66344   -34.76814 7.53406   1.000 14.53061  ? 109 TRP B C   1 
ATOM   1720 O  O   . TRP B 1 73  ? 7.45593   -34.24068 8.31791   1.000 14.32713  ? 109 TRP B O   1 
ATOM   1721 C  CB  . TRP B 1 73  ? 7.90888   -36.40156 6.15681   1.000 12.62601  ? 109 TRP B CB  1 
ATOM   1722 C  CG  . TRP B 1 73  ? 8.14661   -37.14503 4.87351   1.000 13.46637  ? 109 TRP B CG  1 
ATOM   1723 C  CD1 . TRP B 1 73  ? 9.36658   -37.64451 4.45239   1.000 15.24771  ? 109 TRP B CD1 1 
ATOM   1724 C  CD2 . TRP B 1 73  ? 7.17089   -37.64308 3.93799   1.000 16.56486  ? 109 TRP B CD2 1 
ATOM   1725 N  NE1 . TRP B 1 73  ? 9.20521   -38.35951 3.29092   1.000 14.32539  ? 109 TRP B NE1 1 
ATOM   1726 C  CE2 . TRP B 1 73  ? 7.87898   -38.36731 2.94621   1.000 13.72495  ? 109 TRP B CE2 1 
ATOM   1727 C  CE3 . TRP B 1 73  ? 5.77647   -37.50747 3.81170   1.000 14.05551  ? 109 TRP B CE3 1 
ATOM   1728 C  CZ2 . TRP B 1 73  ? 7.23866   -38.97559 1.84724   1.000 16.07543  ? 109 TRP B CZ2 1 
ATOM   1729 C  CZ3 . TRP B 1 73  ? 5.13528   -38.11908 2.71663   1.000 14.66473  ? 109 TRP B CZ3 1 
ATOM   1730 C  CH2 . TRP B 1 73  ? 5.87451   -38.84622 1.75591   1.000 15.50641  ? 109 TRP B CH2 1 
ATOM   1731 N  N   . ILE B 1 74  ? 5.41802   -35.09544 7.88710   1.000 13.12663  ? 110 ILE B N   1 
ATOM   1732 C  CA  . ILE B 1 74  ? 4.93536   -34.96026 9.25807   1.000 13.03853  ? 110 ILE B CA  1 
ATOM   1733 C  C   . ILE B 1 74  ? 4.34123   -36.29618 9.69093   1.000 15.22857  ? 110 ILE B C   1 
ATOM   1734 O  O   . ILE B 1 74  ? 4.20437   -37.22286 8.89723   1.000 14.77806  ? 110 ILE B O   1 
ATOM   1735 C  CB  . ILE B 1 74  ? 3.91481   -33.81122 9.40349   1.000 17.15476  ? 110 ILE B CB  1 
ATOM   1736 C  CG1 . ILE B 1 74  ? 2.67430   -34.06039 8.53987   1.000 16.69305  ? 110 ILE B CG1 1 
ATOM   1737 C  CG2 . ILE B 1 74  ? 4.57488   -32.45479 9.02079   1.000 17.27583  ? 110 ILE B CG2 1 
ATOM   1738 C  CD1 . ILE B 1 74  ? 1.56475   -32.99280 8.74821   1.000 17.13409  ? 110 ILE B CD1 1 
ATOM   1739 N  N   . GLY B 1 75  ? 3.98677   -36.38582 10.97573  1.000 13.21924  ? 111 GLY B N   1 
ATOM   1740 C  CA  . GLY B 1 75  ? 3.67678   -37.66713 11.58659  1.000 17.42429  ? 111 GLY B CA  1 
ATOM   1741 C  C   . GLY B 1 75  ? 2.23137   -38.10067 11.46488  1.000 17.00926  ? 111 GLY B C   1 
ATOM   1742 O  O   . GLY B 1 75  ? 1.63325   -38.51921 12.45579  1.000 15.98856  ? 111 GLY B O   1 
ATOM   1743 N  N   . LEU B 1 76  ? 1.67770   -38.04856 10.25689  1.000 15.68535  ? 112 LEU B N   1 
ATOM   1744 C  CA  . LEU B 1 76  ? 0.29844   -38.45745 10.00708  1.000 15.14974  ? 112 LEU B CA  1 
ATOM   1745 C  C   . LEU B 1 76  ? 0.31764   -39.53984 8.93500   1.000 17.95746  ? 112 LEU B C   1 
ATOM   1746 O  O   . LEU B 1 76  ? 0.99939   -39.38157 7.91818   1.000 17.55146  ? 112 LEU B O   1 
ATOM   1747 C  CB  . LEU B 1 76  ? -0.55530  -37.25785 9.56233   1.000 15.82360  ? 112 LEU B CB  1 
ATOM   1748 C  CG  . LEU B 1 76  ? -2.07383  -37.50353 9.49013   1.000 15.05247  ? 112 LEU B CG  1 
ATOM   1749 C  CD1 . LEU B 1 76  ? -2.62882  -37.84304 10.90163  1.000 15.68077  ? 112 LEU B CD1 1 
ATOM   1750 C  CD2 . LEU B 1 76  ? -2.73557  -36.24833 8.94584   1.000 14.48385  ? 112 LEU B CD2 1 
ATOM   1751 N  N   . MET B 1 77  ? -0.40154  -40.64821 9.16899   1.000 14.30672  ? 113 MET B N   1 
ATOM   1752 C  CA  . MET B 1 77  ? -0.38348  -41.77806 8.24330   1.000 15.33201  ? 113 MET B CA  1 
ATOM   1753 C  C   . MET B 1 77  ? -1.78007  -42.37529 8.11707   1.000 16.08813  ? 113 MET B C   1 
ATOM   1754 O  O   . MET B 1 77  ? -2.57208  -42.34842 9.05659   1.000 17.31706  ? 113 MET B O   1 
ATOM   1755 C  CB  . MET B 1 77  ? 0.60832   -42.90450 8.65493   1.000 17.47102  ? 113 MET B CB  1 
ATOM   1756 C  CG  . MET B 1 77  ? 1.03823   -43.78264 7.44049   1.000 30.95252  ? 113 MET B CG  1 
ATOM   1757 S  SD  . MET B 1 77  ? 2.25118   -45.13067 7.64496   1.000 43.16743  ? 113 MET B SD  1 
ATOM   1758 C  CE  . MET B 1 77  ? 1.76678   -46.24104 6.32318   1.000 45.89493  ? 113 MET B CE  1 
ATOM   1759 N  N   . GLU B 1 78  ? -2.07265  -42.90410 6.93544   1.000 14.97814  ? 114 GLU B N   1 
ATOM   1760 C  CA  . GLU B 1 78  ? -3.35452  -43.56411 6.70764   1.000 16.32381  ? 114 GLU B CA  1 
ATOM   1761 C  C   . GLU B 1 78  ? -3.43139  -44.87490 7.48188   1.000 19.89398  ? 114 GLU B C   1 
ATOM   1762 O  O   . GLU B 1 78  ? -2.42994  -45.57718 7.65965   1.000 18.44415  ? 114 GLU B O   1 
ATOM   1763 C  CB  . GLU B 1 78  ? -3.53459  -43.84175 5.21296   1.000 14.86761  ? 114 GLU B CB  1 
ATOM   1764 C  CG  . GLU B 1 78  ? -4.96992  -44.18311 4.81712   1.000 16.63590  ? 114 GLU B CG  1 
ATOM   1765 C  CD  . GLU B 1 78  ? -5.11639  -44.32114 3.32033   1.000 23.37670  ? 114 GLU B CD  1 
ATOM   1766 O  OE1 . GLU B 1 78  ? -4.12387  -44.06745 2.58810   1.000 17.52737  ? 114 GLU B OE1 1 
ATOM   1767 O  OE2 . GLU B 1 78  ? -6.24292  -44.60734 2.88313   1.000 17.54660  ? 114 GLU B OE2 1 
ATOM   1768 N  N   . GLN B 1 79  ? -4.64772  -45.21565 7.92183   1.000 17.67484  ? 115 GLN B N   1 
ATOM   1769 C  CA  . GLN B 1 79  ? -4.94237  -46.53205 8.48055   1.000 20.38629  ? 115 GLN B CA  1 
ATOM   1770 C  C   . GLN B 1 79  ? -5.26674  -47.44219 7.30035   1.000 23.06007  ? 115 GLN B C   1 
ATOM   1771 O  O   . GLN B 1 79  ? -6.33522  -47.33709 6.69646   1.000 21.15659  ? 115 GLN B O   1 
ATOM   1772 C  CB  . GLN B 1 79  ? -6.08953  -46.43402 9.47912   1.000 23.82894  ? 115 GLN B CB  1 
ATOM   1773 C  CG  . GLN B 1 79  ? -5.88295  -45.31515 10.48384  1.000 26.66976  ? 115 GLN B CG  1 
ATOM   1774 C  CD  . GLN B 1 79  ? -6.89969  -45.33088 11.59631  1.000 31.67316  ? 115 GLN B CD  1 
ATOM   1775 O  OE1 . GLN B 1 79  ? -7.96284  -44.72259 11.47573  1.000 35.26172  ? 115 GLN B OE1 1 
ATOM   1776 N  NE2 . GLN B 1 79  ? -6.56899  -45.99491 12.70106  1.000 33.06302  ? 115 GLN B NE2 1 
ATOM   1777 N  N   . ARG B 1 80  ? -4.28842  -48.25153 6.90595   1.000 22.73401  ? 116 ARG B N   1 
ATOM   1778 C  CA  . ARG B 1 80  ? -4.37556  -49.18092 5.77684   1.000 26.09957  ? 116 ARG B CA  1 
ATOM   1779 C  C   . ARG B 1 80  ? -4.80807  -48.39021 4.53754   1.000 23.79419  ? 116 ARG B C   1 
ATOM   1780 O  O   . ARG B 1 80  ? -4.17133  -47.37360 4.21874   1.000 21.20533  ? 116 ARG B O   1 
ATOM   1781 C  CB  . ARG B 1 80  ? -5.29070  -50.30889 6.21087   1.000 28.08903  ? 116 ARG B CB  1 
ATOM   1782 C  CG  . ARG B 1 80  ? -4.64494  -51.05945 7.37519   1.000 38.89414  ? 116 ARG B CG  1 
ATOM   1783 C  CD  . ARG B 1 80  ? -4.03949  -52.30413 6.90157   1.000 57.38539  ? 116 ARG B CD  1 
ATOM   1784 N  NE  . ARG B 1 80  ? -3.94635  -53.38988 7.87355   1.000 73.56973  ? 116 ARG B NE  1 
ATOM   1785 C  CZ  . ARG B 1 80  ? -2.91036  -53.61135 8.67288   1.000 72.68409  ? 116 ARG B CZ  1 
ATOM   1786 N  NH1 . ARG B 1 80  ? -1.87755  -52.78553 8.71444   1.000 66.05580  ? 116 ARG B NH1 1 
ATOM   1787 N  NH2 . ARG B 1 80  ? -2.89551  -54.70954 9.42445   1.000 74.04969  ? 116 ARG B NH2 1 
ATOM   1788 N  N   . SER B 1 81  ? -5.86046  -48.80701 3.81875   1.000 19.73048  ? 117 SER B N   1 
ATOM   1789 C  CA  . SER B 1 81  ? -6.37882  -48.05842 2.67655   1.000 22.00093  ? 117 SER B CA  1 
ATOM   1790 C  C   . SER B 1 81  ? -7.69884  -47.36393 2.99071   1.000 19.26704  ? 117 SER B C   1 
ATOM   1791 O  O   . SER B 1 81  ? -8.41050  -46.93673 2.06655   1.000 20.41359  ? 117 SER B O   1 
ATOM   1792 C  CB  . SER B 1 81  ? -6.55430  -48.97297 1.46407   1.000 24.05516  ? 117 SER B CB  1 
ATOM   1793 O  OG  . SER B 1 81  ? -5.34049  -49.60843 1.12751   1.000 26.82546  ? 117 SER B OG  1 
ATOM   1794 N  N   . GLU B 1 82  ? -8.02349  -47.21860 4.27761   1.000 18.81762  ? 118 GLU B N   1 
ATOM   1795 C  CA  . GLU B 1 82  ? -9.34755  -46.77553 4.71592   1.000 20.81533  ? 118 GLU B CA  1 
ATOM   1796 C  C   . GLU B 1 82  ? -9.60127  -45.27898 4.58726   1.000 20.42333  ? 118 GLU B C   1 
ATOM   1797 O  O   . GLU B 1 82  ? -10.73653 -44.84039 4.83450   1.000 19.85631  ? 118 GLU B O   1 
ATOM   1798 C  CB  . GLU B 1 82  ? -9.55618  -47.21098 6.16201   1.000 19.73375  ? 118 GLU B CB  1 
ATOM   1799 C  CG  . GLU B 1 82  ? -9.52555  -48.70742 6.27598   1.000 21.63904  ? 118 GLU B CG  1 
ATOM   1800 C  CD  . GLU B 1 82  ? -10.65276 -49.29591 5.46129   1.000 28.93121  ? 118 GLU B CD  1 
ATOM   1801 O  OE1 . GLU B 1 82  ? -11.82204 -49.06773 5.82904   1.000 34.73919  ? 118 GLU B OE1 1 
ATOM   1802 O  OE2 . GLU B 1 82  ? -10.37166 -49.92577 4.42496   1.000 24.31921  ? 118 GLU B OE2 1 
ATOM   1803 N  N   . ARG B 1 83  ? -8.60418  -44.48461 4.19050   1.000 18.57127  ? 119 ARG B N   1 
ATOM   1804 C  CA  . ARG B 1 83  ? -8.77279  -43.03607 4.06591   1.000 16.28334  ? 119 ARG B CA  1 
ATOM   1805 C  C   . ARG B 1 83  ? -9.21195  -42.42999 5.39190   1.000 16.54272  ? 119 ARG B C   1 
ATOM   1806 O  O   . ARG B 1 83  ? -9.95129  -41.44956 5.42601   1.000 18.61168  ? 119 ARG B O   1 
ATOM   1807 C  CB  . ARG B 1 83  ? -9.76908  -42.66600 2.95993   1.000 19.98535  ? 119 ARG B CB  1 
ATOM   1808 C  CG  . ARG B 1 83  ? -9.38351  -43.23365 1.59540   1.000 16.73588  ? 119 ARG B CG  1 
ATOM   1809 C  CD  . ARG B 1 83  ? -8.46967  -42.22787 0.85962   1.000 17.92022  ? 119 ARG B CD  1 
ATOM   1810 N  NE  . ARG B 1 83  ? -7.06229  -42.31518 1.25023   1.000 17.30754  ? 119 ARG B NE  1 
ATOM   1811 C  CZ  . ARG B 1 83  ? -6.14026  -41.47725 0.78711   1.000 17.20745  ? 119 ARG B CZ  1 
ATOM   1812 N  NH1 . ARG B 1 83  ? -6.47579  -40.44505 0.02014   1.000 16.85903  ? 119 ARG B NH1 1 
ATOM   1813 N  NH2 . ARG B 1 83  ? -4.85322  -41.68486 1.08604   1.000 14.12709  ? 119 ARG B NH2 1 
ATOM   1814 N  N   . THR B 1 84  ? -8.78176  -43.05451 6.48185   1.000 17.88770  ? 120 THR B N   1 
ATOM   1815 C  CA  . THR B 1 84  ? -8.83646  -42.43926 7.79217   1.000 15.72991  ? 120 THR B CA  1 
ATOM   1816 C  C   . THR B 1 84  ? -7.39823  -42.33797 8.27918   1.000 15.25609  ? 120 THR B C   1 
ATOM   1817 O  O   . THR B 1 84  ? -6.51476  -43.06783 7.80699   1.000 16.45135  ? 120 THR B O   1 
ATOM   1818 C  CB  . THR B 1 84  ? -9.68722  -43.24873 8.77862   1.000 19.06255  ? 120 THR B CB  1 
ATOM   1819 O  OG1 . THR B 1 84  ? -9.12895  -44.55361 8.94570   1.000 21.38883  ? 120 THR B OG1 1 
ATOM   1820 C  CG2 . THR B 1 84  ? -11.09195 -43.39004 8.23159   1.000 20.41880  ? 120 THR B CG2 1 
ATOM   1821 N  N   . TRP B 1 85  ? -7.16925  -41.43895 9.23097   1.000 17.59557  ? 121 TRP B N   1 
ATOM   1822 C  CA  . TRP B 1 85  ? -5.81676  -40.97591 9.50948   1.000 17.44837  ? 121 TRP B CA  1 
ATOM   1823 C  C   . TRP B 1 85  ? -5.54485  -41.01444 11.00618  1.000 17.76079  ? 121 TRP B C   1 
ATOM   1824 O  O   . TRP B 1 85  ? -6.43129  -40.72917 11.81693  1.000 18.17325  ? 121 TRP B O   1 
ATOM   1825 C  CB  . TRP B 1 85  ? -5.61558  -39.54587 8.96249   1.000 16.79445  ? 121 TRP B CB  1 
ATOM   1826 C  CG  . TRP B 1 85  ? -5.91507  -39.48571 7.51158   1.000 17.21390  ? 121 TRP B CG  1 
ATOM   1827 C  CD1 . TRP B 1 85  ? -7.11863  -39.21720 6.94155   1.000 18.64996  ? 121 TRP B CD1 1 
ATOM   1828 C  CD2 . TRP B 1 85  ? -4.99816  -39.72341 6.44148   1.000 17.04439  ? 121 TRP B CD2 1 
ATOM   1829 N  NE1 . TRP B 1 85  ? -7.01575  -39.27310 5.57879   1.000 16.95831  ? 121 TRP B NE1 1 
ATOM   1830 C  CE2 . TRP B 1 85  ? -5.72159  -39.58720 5.24169   1.000 16.83981  ? 121 TRP B CE2 1 
ATOM   1831 C  CE3 . TRP B 1 85  ? -3.63156  -40.03425 6.38225   1.000 15.34785  ? 121 TRP B CE3 1 
ATOM   1832 C  CZ2 . TRP B 1 85  ? -5.12996  -39.75117 3.97970   1.000 19.52770  ? 121 TRP B CZ2 1 
ATOM   1833 C  CZ3 . TRP B 1 85  ? -3.03831  -40.20705 5.13165   1.000 16.08610  ? 121 TRP B CZ3 1 
ATOM   1834 C  CH2 . TRP B 1 85  ? -3.78438  -40.06274 3.94409   1.000 18.82386  ? 121 TRP B CH2 1 
ATOM   1835 N  N   . ARG B 1 86  ? -4.30684  -41.36064 11.35167  1.000 16.23805  ? 122 ARG B N   1 
ATOM   1836 C  CA  . ARG B 1 86  ? -3.83866  -41.48683 12.72215  1.000 18.14969  ? 122 ARG B CA  1 
ATOM   1837 C  C   . ARG B 1 86  ? -2.47805  -40.81478 12.85603  1.000 21.45055  ? 122 ARG B C   1 
ATOM   1838 O  O   . ARG B 1 86  ? -1.61069  -40.98414 11.99391  1.000 20.38410  ? 122 ARG B O   1 
ATOM   1839 C  CB  . ARG B 1 86  ? -3.74986  -42.97860 13.09483  1.000 21.94515  ? 122 ARG B CB  1 
ATOM   1840 C  CG  . ARG B 1 86  ? -2.71079  -43.35147 14.11452  1.000 41.04941  ? 122 ARG B CG  1 
ATOM   1841 C  CD  . ARG B 1 86  ? -2.64320  -44.86720 14.29680  1.000 52.65911  ? 122 ARG B CD  1 
ATOM   1842 N  NE  . ARG B 1 86  ? -1.40353  -45.40736 13.73367  1.000 61.58895  ? 122 ARG B NE  1 
ATOM   1843 C  CZ  . ARG B 1 86  ? -0.21783  -45.39257 14.32958  1.000 50.98211  ? 122 ARG B CZ  1 
ATOM   1844 N  NH1 . ARG B 1 86  ? -0.05739  -44.88440 15.53739  1.000 50.90880  ? 122 ARG B NH1 1 
ATOM   1845 N  NH2 . ARG B 1 86  ? 0.83725   -45.89742 13.69169  1.000 62.61306  ? 122 ARG B NH2 1 
ATOM   1846 N  N   . TRP B 1 87  ? -2.28970  -40.06228 13.93961  1.000 17.31261  ? 123 TRP B N   1 
ATOM   1847 C  CA  . TRP B 1 87  ? -0.96586  -39.50335 14.20122  1.000 17.53864  ? 123 TRP B CA  1 
ATOM   1848 C  C   . TRP B 1 87  ? -0.02935  -40.59686 14.70560  1.000 20.38767  ? 123 TRP B C   1 
ATOM   1849 O  O   . TRP B 1 87  ? -0.46109  -41.64593 15.19027  1.000 21.17703  ? 123 TRP B O   1 
ATOM   1850 C  CB  . TRP B 1 87  ? -1.04505  -38.36850 15.23634  1.000 15.78039  ? 123 TRP B CB  1 
ATOM   1851 C  CG  . TRP B 1 87  ? -1.78928  -37.15792 14.74165  1.000 15.62388  ? 123 TRP B CG  1 
ATOM   1852 C  CD1 . TRP B 1 87  ? -3.08604  -36.81707 15.00800  1.000 16.22863  ? 123 TRP B CD1 1 
ATOM   1853 C  CD2 . TRP B 1 87  ? -1.28948  -36.16017 13.85158  1.000 15.49925  ? 123 TRP B CD2 1 
ATOM   1854 N  NE1 . TRP B 1 87  ? -3.41604  -35.64858 14.35539  1.000 19.18918  ? 123 TRP B NE1 1 
ATOM   1855 C  CE2 . TRP B 1 87  ? -2.32753  -35.22773 13.63774  1.000 17.88475  ? 123 TRP B CE2 1 
ATOM   1856 C  CE3 . TRP B 1 87  ? -0.05872  -35.96044 13.21517  1.000 14.28200  ? 123 TRP B CE3 1 
ATOM   1857 C  CZ2 . TRP B 1 87  ? -2.17686  -34.12043 12.80560  1.000 18.82243  ? 123 TRP B CZ2 1 
ATOM   1858 C  CZ3 . TRP B 1 87  ? 0.09279   -34.84704 12.39467  1.000 14.26317  ? 123 TRP B CZ3 1 
ATOM   1859 C  CH2 . TRP B 1 87  ? -0.95897  -33.94744 12.19668  1.000 17.83048  ? 123 TRP B CH2 1 
ATOM   1860 N  N   . VAL B 1 88  ? 1.27833   -40.33062 14.62064  1.000 16.70618  ? 124 VAL B N   1 
ATOM   1861 C  CA  . VAL B 1 88  ? 2.25592   -41.35636 14.97475  1.000 14.57699  ? 124 VAL B CA  1 
ATOM   1862 C  C   . VAL B 1 88  ? 2.18643   -41.76048 16.44353  1.000 19.22651  ? 124 VAL B C   1 
ATOM   1863 O  O   . VAL B 1 88  ? 2.71170   -42.81672 16.80922  1.000 24.65067  ? 124 VAL B O   1 
ATOM   1864 C  CB  . VAL B 1 88  ? 3.69149   -40.90296 14.62853  1.000 17.58384  ? 124 VAL B CB  1 
ATOM   1865 C  CG1 . VAL B 1 88  ? 3.89487   -41.01091 13.11635  1.000 17.93767  ? 124 VAL B CG1 1 
ATOM   1866 C  CG2 . VAL B 1 88  ? 3.96585   -39.45706 15.15283  1.000 19.68207  ? 124 VAL B CG2 1 
ATOM   1867 N  N   . ASP B 1 89  ? 1.56652   -40.95103 17.30075  1.000 20.84687  ? 125 ASP B N   1 
ATOM   1868 C  CA  . ASP B 1 89  ? 1.41586   -41.34848 18.69763  1.000 22.61742  ? 125 ASP B CA  1 
ATOM   1869 C  C   . ASP B 1 89  ? 0.15403   -42.16694 18.91847  1.000 28.96203  ? 125 ASP B C   1 
ATOM   1870 O  O   . ASP B 1 89  ? -0.18602  -42.46829 20.06663  1.000 27.15480  ? 125 ASP B O   1 
ATOM   1871 C  CB  . ASP B 1 89  ? 1.42126   -40.12357 19.62247  1.000 22.47117  ? 125 ASP B CB  1 
ATOM   1872 C  CG  . ASP B 1 89  ? 0.21786   -39.21270 19.42620  1.000 25.99086  ? 125 ASP B CG  1 
ATOM   1873 O  OD1 . ASP B 1 89  ? -0.54306  -39.39601 18.46360  1.000 23.02636  ? 125 ASP B OD1 1 
ATOM   1874 O  OD2 . ASP B 1 89  ? 0.04373   -38.27317 20.23204  1.000 31.07414  ? 125 ASP B OD2 1 
ATOM   1875 N  N   . GLY B 1 90  ? -0.54777  -42.51711 17.84202  1.000 25.95042  ? 126 GLY B N   1 
ATOM   1876 C  CA  . GLY B 1 90  ? -1.76014  -43.29732 17.92318  1.000 26.29245  ? 126 GLY B CA  1 
ATOM   1877 C  C   . GLY B 1 90  ? -3.04556  -42.50138 17.96768  1.000 25.97684  ? 126 GLY B C   1 
ATOM   1878 O  O   . GLY B 1 90  ? -4.12296  -43.09701 17.82957  1.000 28.51067  ? 126 GLY B O   1 
ATOM   1879 N  N   . THR B 1 91  ? -2.98282  -41.18333 18.14755  1.000 23.01295  ? 127 THR B N   1 
ATOM   1880 C  CA  A THR B 1 91  ? -4.21694  -40.41950 18.28703  0.728 22.96920  ? 127 THR B CA  1 
ATOM   1881 C  CA  B THR B 1 91  ? -4.20979  -40.41249 18.28642  0.272 22.89238  ? 127 THR B CA  1 
ATOM   1882 C  C   . THR B 1 91  ? -4.89980  -40.25956 16.93097  1.000 30.74598  ? 127 THR B C   1 
ATOM   1883 O  O   . THR B 1 91  ? -4.23093  -40.08348 15.90293  1.000 22.79560  ? 127 THR B O   1 
ATOM   1884 C  CB  A THR B 1 91  ? -3.95920  -39.04203 18.91992  0.728 27.81677  ? 127 THR B CB  1 
ATOM   1885 C  CB  B THR B 1 91  ? -3.91679  -39.04279 18.91015  0.272 27.82658  ? 127 THR B CB  1 
ATOM   1886 O  OG1 A THR B 1 91  ? -3.13327  -38.23351 18.06641  0.728 29.60808  ? 127 THR B OG1 1 
ATOM   1887 O  OG1 B THR B 1 91  ? -5.13574  -38.41502 19.32607  0.272 27.23996  ? 127 THR B OG1 1 
ATOM   1888 C  CG2 A THR B 1 91  ? -3.28923  -39.19974 20.28546  0.728 24.47714  ? 127 THR B CG2 1 
ATOM   1889 C  CG2 B THR B 1 91  ? -3.20102  -38.15446 17.94985  0.272 29.16962  ? 127 THR B CG2 1 
ATOM   1890 N  N   . PRO B 1 92  ? -6.22443  -40.34706 16.88975  1.000 29.20561  ? 128 PRO B N   1 
ATOM   1891 C  CA  . PRO B 1 92  ? -6.92393  -40.19216 15.61498  1.000 24.44973  ? 128 PRO B CA  1 
ATOM   1892 C  C   . PRO B 1 92  ? -6.86562  -38.74512 15.17557  1.000 22.21361  ? 128 PRO B C   1 
ATOM   1893 O  O   . PRO B 1 92  ? -6.73868  -37.82808 15.98518  1.000 20.87675  ? 128 PRO B O   1 
ATOM   1894 C  CB  . PRO B 1 92  ? -8.36526  -40.61546 15.91591  1.000 32.20351  ? 128 PRO B CB  1 
ATOM   1895 C  CG  . PRO B 1 92  ? -8.46727  -40.74399 17.38919  1.000 39.46820  ? 128 PRO B CG  1 
ATOM   1896 C  CD  . PRO B 1 92  ? -7.12287  -40.63713 18.01980  1.000 34.95357  ? 128 PRO B CD  1 
ATOM   1897 N  N   . LEU B 1 93  ? -6.96275  -38.54584 13.86288  1.000 21.65655  ? 129 LEU B N   1 
ATOM   1898 C  CA  . LEU B 1 93  ? -6.98621  -37.19305 13.32745  1.000 21.79792  ? 129 LEU B CA  1 
ATOM   1899 C  C   . LEU B 1 93  ? -8.27027  -36.50305 13.75897  1.000 20.33222  ? 129 LEU B C   1 
ATOM   1900 O  O   . LEU B 1 93  ? -9.35653  -37.08002 13.64912  1.000 21.86018  ? 129 LEU B O   1 
ATOM   1901 C  CB  . LEU B 1 93  ? -6.88630  -37.22472 11.79722  1.000 16.86824  ? 129 LEU B CB  1 
ATOM   1902 C  CG  . LEU B 1 93  ? -7.11723  -35.89669 11.05087  1.000 16.36754  ? 129 LEU B CG  1 
ATOM   1903 C  CD1 . LEU B 1 93  ? -5.97243  -34.91522 11.32434  1.000 20.02646  ? 129 LEU B CD1 1 
ATOM   1904 C  CD2 . LEU B 1 93  ? -7.23377  -36.12756 9.55148   1.000 19.40869  ? 129 LEU B CD2 1 
ATOM   1905 N  N   . THR B 1 94  ? -8.14884  -35.27645 14.26832  1.000 21.27967  ? 130 THR B N   1 
ATOM   1906 C  CA  . THR B 1 94  ? -9.33439  -34.45542 14.47341  1.000 24.94536  ? 130 THR B CA  1 
ATOM   1907 C  C   . THR B 1 94  ? -9.21703  -33.20641 13.60948  1.000 29.94558  ? 130 THR B C   1 
ATOM   1908 O  O   . THR B 1 94  ? -9.60306  -33.22284 12.43414  1.000 26.86001  ? 130 THR B O   1 
ATOM   1909 C  CB  . THR B 1 94  ? -9.53405  -34.11146 15.95671  1.000 27.49352  ? 130 THR B CB  1 
ATOM   1910 O  OG1 . THR B 1 94  ? -8.33140  -33.55881 16.50716  1.000 31.65756  ? 130 THR B OG1 1 
ATOM   1911 C  CG2 . THR B 1 94  ? -9.89834  -35.36980 16.72921  1.000 27.75887  ? 130 THR B CG2 1 
ATOM   1912 N  N   . GLU B 1 95  ? -8.66218  -32.13398 14.16258  1.000 22.28060  ? 131 GLU B N   1 
ATOM   1913 C  CA  . GLU B 1 95  ? -8.50959  -30.90012 13.40798  1.000 20.13954  ? 131 GLU B CA  1 
ATOM   1914 C  C   . GLU B 1 95  ? -7.46974  -31.10834 12.30694  1.000 21.69669  ? 131 GLU B C   1 
ATOM   1915 O  O   . GLU B 1 95  ? -6.42018  -31.71115 12.53607  1.000 21.24197  ? 131 GLU B O   1 
ATOM   1916 C  CB  . GLU B 1 95  ? -8.07500  -29.79055 14.36596  1.000 27.83473  ? 131 GLU B CB  1 
ATOM   1917 C  CG  . GLU B 1 95  ? -9.19275  -29.37519 15.32818  1.000 39.64798  ? 131 GLU B CG  1 
ATOM   1918 C  CD  . GLU B 1 95  ? -8.90019  -28.08096 16.05638  1.000 51.99796  ? 131 GLU B CD  1 
ATOM   1919 O  OE1 . GLU B 1 95  ? -9.86326  -27.34701 16.37133  1.000 61.01056  ? 131 GLU B OE1 1 
ATOM   1920 O  OE2 . GLU B 1 95  ? -7.70584  -27.80309 16.31520  1.000 50.94008  ? 131 GLU B OE2 1 
ATOM   1921 N  N   . SER B 1 96  ? -7.77185  -30.64345 11.10113  1.000 21.67771  ? 132 SER B N   1 
ATOM   1922 C  CA  . SER B 1 96  ? -6.94427  -30.96960 9.94870   1.000 20.55588  ? 132 SER B CA  1 
ATOM   1923 C  C   . SER B 1 96  ? -6.65949  -29.70965 9.13990   1.000 18.42427  ? 132 SER B C   1 
ATOM   1924 O  O   . SER B 1 96  ? -7.36812  -28.70170 9.25008   1.000 20.83279  ? 132 SER B O   1 
ATOM   1925 C  CB  . SER B 1 96  ? -7.61538  -32.04236 9.08185   1.000 22.73351  ? 132 SER B CB  1 
ATOM   1926 O  OG  . SER B 1 96  ? -8.78629  -31.51827 8.47056   1.000 23.97039  ? 132 SER B OG  1 
ATOM   1927 N  N   . TYR B 1 97  ? -5.58466  -29.76182 8.34740   1.000 18.69093  ? 133 TYR B N   1 
ATOM   1928 C  CA  . TYR B 1 97  ? -5.15846  -28.62622 7.53030   1.000 19.58330  ? 133 TYR B CA  1 
ATOM   1929 C  C   . TYR B 1 97  ? -4.76158  -29.10129 6.13959   1.000 20.68462  ? 133 TYR B C   1 
ATOM   1930 O  O   . TYR B 1 97  ? -3.72018  -28.71568 5.60316   1.000 20.44085  ? 133 TYR B O   1 
ATOM   1931 C  CB  . TYR B 1 97  ? -3.99990  -27.86629 8.19543   1.000 20.02875  ? 133 TYR B CB  1 
ATOM   1932 C  CG  . TYR B 1 97  ? -4.38772  -27.37517 9.56084   1.000 19.98377  ? 133 TYR B CG  1 
ATOM   1933 C  CD1 . TYR B 1 97  ? -5.15159  -26.22708 9.70241   1.000 21.92470  ? 133 TYR B CD1 1 
ATOM   1934 C  CD2 . TYR B 1 97  ? -4.03536  -28.08143 10.69781  1.000 17.11502  ? 133 TYR B CD2 1 
ATOM   1935 C  CE1 . TYR B 1 97  ? -5.55879  -25.78183 10.96613  1.000 20.76237  ? 133 TYR B CE1 1 
ATOM   1936 C  CE2 . TYR B 1 97  ? -4.42958  -27.63870 11.96795  1.000 21.77872  ? 133 TYR B CE2 1 
ATOM   1937 C  CZ  . TYR B 1 97  ? -5.19159  -26.48451 12.08100  1.000 23.19846  ? 133 TYR B CZ  1 
ATOM   1938 O  OH  . TYR B 1 97  ? -5.59371  -26.04128 13.32273  1.000 28.97641  ? 133 TYR B OH  1 
ATOM   1939 N  N   . TRP B 1 98  ? -5.60168  -29.95533 5.54429   1.000 18.89442  ? 134 TRP B N   1 
ATOM   1940 C  CA  . TRP B 1 98  ? -5.34362  -30.45307 4.20103   1.000 18.29184  ? 134 TRP B CA  1 
ATOM   1941 C  C   . TRP B 1 98  ? -5.34861  -29.31497 3.19529   1.000 18.61483  ? 134 TRP B C   1 
ATOM   1942 O  O   . TRP B 1 98  ? -6.18302  -28.39689 3.26028   1.000 17.67840  ? 134 TRP B O   1 
ATOM   1943 C  CB  . TRP B 1 98  ? -6.41433  -31.47165 3.77366   1.000 18.04477  ? 134 TRP B CB  1 
ATOM   1944 C  CG  . TRP B 1 98  ? -6.50428  -32.71811 4.57791   1.000 19.95956  ? 134 TRP B CG  1 
ATOM   1945 C  CD1 . TRP B 1 98  ? -7.50459  -33.06225 5.45633   1.000 19.54303  ? 134 TRP B CD1 1 
ATOM   1946 C  CD2 . TRP B 1 98  ? -5.59128  -33.81259 4.55990   1.000 17.38043  ? 134 TRP B CD2 1 
ATOM   1947 N  NE1 . TRP B 1 98  ? -7.25306  -34.29803 6.00220   1.000 19.02343  ? 134 TRP B NE1 1 
ATOM   1948 C  CE2 . TRP B 1 98  ? -6.08627  -34.78488 5.46227   1.000 18.15608  ? 134 TRP B CE2 1 
ATOM   1949 C  CE3 . TRP B 1 98  ? -4.39538  -34.07413 3.86047   1.000 14.20487  ? 134 TRP B CE3 1 
ATOM   1950 C  CZ2 . TRP B 1 98  ? -5.43773  -35.99662 5.68780   1.000 17.83682  ? 134 TRP B CZ2 1 
ATOM   1951 C  CZ3 . TRP B 1 98  ? -3.74424  -35.27918 4.09546   1.000 15.62222  ? 134 TRP B CZ3 1 
ATOM   1952 C  CH2 . TRP B 1 98  ? -4.26111  -36.22557 5.01021   1.000 16.31858  ? 134 TRP B CH2 1 
ATOM   1953 N  N   . SER B 1 99  ? -4.41448  -29.38678 2.24944   1.000 18.11112  ? 135 SER B N   1 
ATOM   1954 C  CA  A SER B 1 99  ? -4.46692  -28.45134 1.14470   0.462 18.99500  ? 135 SER B CA  1 
ATOM   1955 C  CA  B SER B 1 99  ? -4.41610  -28.51372 1.08732   0.538 19.04030  ? 135 SER B CA  1 
ATOM   1956 C  C   . SER B 1 99  ? -5.66063  -28.78542 0.25326   1.000 27.16735  ? 135 SER B C   1 
ATOM   1957 O  O   . SER B 1 99  ? -6.22341  -29.88423 0.29462   1.000 21.88628  ? 135 SER B O   1 
ATOM   1958 C  CB  A SER B 1 99  ? -3.16014  -28.46894 0.35209   0.462 22.99416  ? 135 SER B CB  1 
ATOM   1959 C  CB  B SER B 1 99  ? -3.15660  -28.75176 0.25285   0.538 22.46202  ? 135 SER B CB  1 
ATOM   1960 O  OG  A SER B 1 99  ? -2.74455  -29.78681 0.06725   0.462 22.82527  ? 135 SER B OG  1 
ATOM   1961 O  OG  B SER B 1 99  ? -2.94616  -27.70824 -0.67774  0.538 22.19145  ? 135 SER B OG  1 
ATOM   1962 N  N   . LEU B 1 100 ? -6.08356  -27.78540 -0.52373  1.000 23.99037  ? 136 LEU B N   1 
ATOM   1963 C  CA  . LEU B 1 100 ? -7.31904  -27.92650 -1.28366  1.000 28.88889  ? 136 LEU B CA  1 
ATOM   1964 C  C   . LEU B 1 100 ? -7.21512  -29.11444 -2.22985  1.000 21.84276  ? 136 LEU B C   1 
ATOM   1965 O  O   . LEU B 1 100 ? -6.22410  -29.26693 -2.94994  1.000 23.80659  ? 136 LEU B O   1 
ATOM   1966 C  CB  . LEU B 1 100 ? -7.61678  -26.64195 -2.06351  1.000 32.77117  ? 136 LEU B CB  1 
ATOM   1967 C  CG  . LEU B 1 100 ? -8.98703  -26.53165 -2.73903  1.000 47.26243  ? 136 LEU B CG  1 
ATOM   1968 C  CD1 . LEU B 1 100 ? -10.11142 -26.57186 -1.70653  1.000 42.82632  ? 136 LEU B CD1 1 
ATOM   1969 C  CD2 . LEU B 1 100 ? -9.07360  -25.26203 -3.59299  1.000 45.92965  ? 136 LEU B CD2 1 
ATOM   1970 N  N   . GLY B 1 101 ? -8.23579  -29.97038 -2.20154  1.000 20.66745  ? 137 GLY B N   1 
ATOM   1971 C  CA  . GLY B 1 101 ? -8.27000  -31.16045 -3.01786  1.000 20.99775  ? 137 GLY B CA  1 
ATOM   1972 C  C   . GLY B 1 101 ? -7.62915  -32.37514 -2.38239  1.000 24.11527  ? 137 GLY B C   1 
ATOM   1973 O  O   . GLY B 1 101 ? -7.68679  -33.46235 -2.96865  1.000 23.43881  ? 137 GLY B O   1 
ATOM   1974 N  N   . GLU B 1 102 ? -7.02673  -32.23196 -1.20084  1.000 18.04588  ? 138 GLU B N   1 
ATOM   1975 C  CA  . GLU B 1 102 ? -6.35736  -33.36220 -0.57075  1.000 15.11715  ? 138 GLU B CA  1 
ATOM   1976 C  C   . GLU B 1 102 ? -7.17334  -33.83137 0.61812   1.000 16.78428  ? 138 GLU B C   1 
ATOM   1977 O  O   . GLU B 1 102 ? -7.94389  -33.05450 1.19169   1.000 20.42223  ? 138 GLU B O   1 
ATOM   1978 C  CB  . GLU B 1 102 ? -4.95749  -32.95552 -0.08708  1.000 15.79016  ? 138 GLU B CB  1 
ATOM   1979 C  CG  . GLU B 1 102 ? -4.07582  -32.37063 -1.20820  1.000 15.97345  ? 138 GLU B CG  1 
ATOM   1980 C  CD  . GLU B 1 102 ? -3.77286  -33.33557 -2.34067  1.000 18.38468  ? 138 GLU B CD  1 
ATOM   1981 O  OE1 . GLU B 1 102 ? -3.90474  -34.56030 -2.14429  1.000 16.57587  ? 138 GLU B OE1 1 
ATOM   1982 O  OE2 . GLU B 1 102 ? -3.33847  -32.85878 -3.43137  1.000 19.49784  ? 138 GLU B OE2 1 
ATOM   1983 N  N   . PRO B 1 103 ? -7.02405  -35.09738 1.03089   1.000 16.57709  ? 139 PRO B N   1 
ATOM   1984 C  CA  . PRO B 1 103 ? -6.15986  -36.13641 0.44453   1.000 15.25886  ? 139 PRO B CA  1 
ATOM   1985 C  C   . PRO B 1 103 ? -6.83511  -36.74109 -0.77435  1.000 18.10250  ? 139 PRO B C   1 
ATOM   1986 O  O   . PRO B 1 103 ? -8.08160  -36.75707 -0.85410  1.000 17.06582  ? 139 PRO B O   1 
ATOM   1987 C  CB  . PRO B 1 103 ? -5.99855  -37.13621 1.59655   1.000 18.37610  ? 139 PRO B CB  1 
ATOM   1988 C  CG  . PRO B 1 103 ? -7.31521  -37.03359 2.34649   1.000 17.18334  ? 139 PRO B CG  1 
ATOM   1989 C  CD  . PRO B 1 103 ? -7.73900  -35.58737 2.22748   1.000 15.92673  ? 139 PRO B CD  1 
ATOM   1990 N  N   . ASN B 1 104 ? -6.07174  -37.26163 -1.73186  1.000 15.66377  ? 140 ASN B N   1 
ATOM   1991 C  CA  . ASN B 1 104 ? -6.69078  -37.66878 -2.98960  1.000 16.76783  ? 140 ASN B CA  1 
ATOM   1992 C  C   . ASN B 1 104 ? -6.19913  -38.96255 -3.63365  1.000 17.29049  ? 140 ASN B C   1 
ATOM   1993 O  O   . ASN B 1 104 ? -6.75434  -39.32376 -4.67432  1.000 18.51556  ? 140 ASN B O   1 
ATOM   1994 C  CB  . ASN B 1 104 ? -6.55265  -36.54036 -4.02735  1.000 18.41232  ? 140 ASN B CB  1 
ATOM   1995 C  CG  . ASN B 1 104 ? -5.09669  -36.29929 -4.42401  1.000 21.87409  ? 140 ASN B CG  1 
ATOM   1996 O  OD1 . ASN B 1 104 ? -4.18920  -36.88000 -3.82635  1.000 16.26475  ? 140 ASN B OD1 1 
ATOM   1997 N  ND2 . ASN B 1 104 ? -4.87281  -35.47547 -5.44817  1.000 18.08645  ? 140 ASN B ND2 1 
ATOM   1998 N  N   . ASN B 1 105 ? -5.20434  -39.67621 -3.08854  1.000 15.53058  ? 141 ASN B N   1 
ATOM   1999 C  CA  . ASN B 1 105 ? -4.64845  -40.85858 -3.78427  1.000 15.05660  ? 141 ASN B CA  1 
ATOM   2000 C  C   . ASN B 1 105 ? -4.41815  -40.53927 -5.26112  1.000 20.24908  ? 141 ASN B C   1 
ATOM   2001 O  O   . ASN B 1 105 ? -4.92556  -41.21945 -6.16053  1.000 19.71105  ? 141 ASN B O   1 
ATOM   2002 C  CB  . ASN B 1 105 ? -5.55947  -42.09735 -3.66230  1.000 14.77533  ? 141 ASN B CB  1 
ATOM   2003 C  CG  . ASN B 1 105 ? -5.39089  -42.85226 -2.35264  1.000 16.83387  ? 141 ASN B CG  1 
ATOM   2004 O  OD1 . ASN B 1 105 ? -4.29538  -42.94581 -1.80381  1.000 17.55035  ? 141 ASN B OD1 1 
ATOM   2005 N  ND2 . ASN B 1 105 ? -6.50445  -43.42187 -1.84237  1.000 14.45464  ? 141 ASN B ND2 1 
ATOM   2006 N  N   . TYR B 1 106 ? -3.66860  -39.45980 -5.48396  1.000 20.04775  ? 142 TYR B N   1 
ATOM   2007 C  CA  . TYR B 1 106 ? -3.43637  -38.84916 -6.79154  1.000 19.22052  ? 142 TYR B CA  1 
ATOM   2008 C  C   . TYR B 1 106 ? -3.22305  -39.87507 -7.90203  1.000 20.80356  ? 142 TYR B C   1 
ATOM   2009 O  O   . TYR B 1 106 ? -2.37933  -40.76336 -7.78843  1.000 23.12981  ? 142 TYR B O   1 
ATOM   2010 C  CB  . TYR B 1 106 ? -2.20602  -37.93678 -6.67428  1.000 18.92639  ? 142 TYR B CB  1 
ATOM   2011 C  CG  . TYR B 1 106 ? -1.89534  -37.12254 -7.90323  1.000 22.83306  ? 142 TYR B CG  1 
ATOM   2012 C  CD1 . TYR B 1 106 ? -2.80601  -36.19571 -8.39248  1.000 25.16367  ? 142 TYR B CD1 1 
ATOM   2013 C  CD2 . TYR B 1 106 ? -0.67038  -37.26423 -8.55460  1.000 27.13259  ? 142 TYR B CD2 1 
ATOM   2014 C  CE1 . TYR B 1 106 ? -2.51388  -35.43226 -9.51050  1.000 29.47456  ? 142 TYR B CE1 1 
ATOM   2015 C  CE2 . TYR B 1 106 ? -0.36746  -36.50040 -9.67328  1.000 28.95910  ? 142 TYR B CE2 1 
ATOM   2016 C  CZ  . TYR B 1 106 ? -1.29717  -35.59375 -10.14622 1.000 27.00300  ? 142 TYR B CZ  1 
ATOM   2017 O  OH  . TYR B 1 106 ? -1.01292  -34.82507 -11.25288 1.000 34.27839  ? 142 TYR B OH  1 
ATOM   2018 N  N   . GLU B 1 107 ? -3.99522  -39.74427 -8.98540  1.000 21.33675  ? 143 GLU B N   1 
ATOM   2019 C  CA  . GLU B 1 107 ? -3.86224  -40.60905 -10.16667 1.000 21.70057  ? 143 GLU B CA  1 
ATOM   2020 C  C   . GLU B 1 107 ? -4.05812  -42.09537 -9.85289  1.000 27.01413  ? 143 GLU B C   1 
ATOM   2021 O  O   . GLU B 1 107 ? -3.57422  -42.96695 -10.58625 1.000 27.76923  ? 143 GLU B O   1 
ATOM   2022 C  CB  . GLU B 1 107 ? -2.51109  -40.36807 -10.85786 1.000 25.55794  ? 143 GLU B CB  1 
ATOM   2023 C  CG  . GLU B 1 107 ? -2.44579  -38.93331 -11.37004 1.000 29.21779  ? 143 GLU B CG  1 
ATOM   2024 C  CD  . GLU B 1 107 ? -1.18097  -38.61452 -12.13618 1.000 42.04058  ? 143 GLU B CD  1 
ATOM   2025 O  OE1 . GLU B 1 107 ? -0.19644  -39.36930 -12.00590 1.000 39.31822  ? 143 GLU B OE1 1 
ATOM   2026 O  OE2 . GLU B 1 107 ? -1.18588  -37.60611 -12.87500 1.000 39.86461  ? 143 GLU B OE2 1 
ATOM   2027 N  N   . GLY B 1 108 ? -4.78703  -42.41432 -8.78621  1.000 19.88958  ? 144 GLY B N   1 
ATOM   2028 C  CA  . GLY B 1 108 ? -5.08161  -43.79039 -8.46883  1.000 20.03550  ? 144 GLY B CA  1 
ATOM   2029 C  C   . GLY B 1 108 ? -3.98926  -44.50269 -7.71486  1.000 22.22788  ? 144 GLY B C   1 
ATOM   2030 O  O   . GLY B 1 108 ? -4.11917  -45.70296 -7.46171  1.000 25.04338  ? 144 GLY B O   1 
ATOM   2031 N  N   . ARG B 1 109 ? -2.92115  -43.79971 -7.34721  1.000 20.45803  ? 145 ARG B N   1 
ATOM   2032 C  CA  . ARG B 1 109 ? -1.78595  -44.40117 -6.67168  1.000 22.43232  ? 145 ARG B CA  1 
ATOM   2033 C  C   . ARG B 1 109 ? -2.00335  -44.26506 -5.17239  1.000 18.50478  ? 145 ARG B C   1 
ATOM   2034 O  O   . ARG B 1 109 ? -2.66863  -43.33065 -4.71127  1.000 18.26510  ? 145 ARG B O   1 
ATOM   2035 C  CB  . ARG B 1 109 ? -0.47611  -43.73408 -7.12356  1.000 28.72612  ? 145 ARG B CB  1 
ATOM   2036 C  CG  . ARG B 1 109 ? -0.26665  -42.31455 -6.62223  1.000 45.85099  ? 145 ARG B CG  1 
ATOM   2037 C  CD  . ARG B 1 109 ? 0.87203   -41.58715 -7.35527  1.000 43.45174  ? 145 ARG B CD  1 
ATOM   2038 N  NE  . ARG B 1 109 ? 1.06384   -40.24298 -6.82213  1.000 53.79011  ? 145 ARG B NE  1 
ATOM   2039 C  CZ  . ARG B 1 109 ? 2.07369   -39.43553 -7.12466  1.000 56.49569  ? 145 ARG B CZ  1 
ATOM   2040 N  NH1 . ARG B 1 109 ? 2.97944   -39.76701 -8.03538  1.000 63.62083  ? 145 ARG B NH1 1 
ATOM   2041 N  NH2 . ARG B 1 109 ? 2.15943   -38.25451 -6.51883  1.000 48.31832  ? 145 ARG B NH2 1 
ATOM   2042 N  N   . GLN B 1 110 ? -1.51194  -45.25772 -4.43705  1.000 17.55155  ? 146 GLN B N   1 
ATOM   2043 C  CA  . GLN B 1 110 ? -1.60518  -45.28767 -2.98386  1.000 16.39953  ? 146 GLN B CA  1 
ATOM   2044 C  C   . GLN B 1 110 ? -0.72771  -44.22493 -2.34876  1.000 18.57831  ? 146 GLN B C   1 
ATOM   2045 O  O   . GLN B 1 110 ? 0.49609   -44.26294 -2.48581  1.000 18.40866  ? 146 GLN B O   1 
ATOM   2046 C  CB  . GLN B 1 110 ? -1.20845  -46.66500 -2.47063  1.000 20.91851  ? 146 GLN B CB  1 
ATOM   2047 C  CG  . GLN B 1 110 ? -1.48234  -46.80307 -1.00160  1.000 26.24632  ? 146 GLN B CG  1 
ATOM   2048 C  CD  . GLN B 1 110 ? -2.28470  -48.03107 -0.66643  1.000 48.58397  ? 146 GLN B CD  1 
ATOM   2049 O  OE1 . GLN B 1 110 ? -1.78351  -49.15538 -0.73843  1.000 43.22911  ? 146 GLN B OE1 1 
ATOM   2050 N  NE2 . GLN B 1 110 ? -3.55059  -47.81915 -0.26982  1.000 26.92218  ? 146 GLN B NE2 1 
ATOM   2051 N  N   . GLU B 1 111 ? -1.35181  -43.31669 -1.60400  1.000 16.40028  ? 147 GLU B N   1 
ATOM   2052 C  CA  . GLU B 1 111 ? -0.65012  -42.21531 -0.93935  1.000 14.57095  ? 147 GLU B CA  1 
ATOM   2053 C  C   . GLU B 1 111 ? -1.02023  -42.27371 0.53878   1.000 15.39274  ? 147 GLU B C   1 
ATOM   2054 O  O   . GLU B 1 111 ? -2.00288  -41.64849 0.93588   1.000 14.93523  ? 147 GLU B O   1 
ATOM   2055 C  CB  . GLU B 1 111 ? -1.06270  -40.89058 -1.56192  1.000 13.93722  ? 147 GLU B CB  1 
ATOM   2056 C  CG  . GLU B 1 111 ? -0.66821  -40.76080 -3.04057  1.000 16.48080  ? 147 GLU B CG  1 
ATOM   2057 C  CD  . GLU B 1 111 ? -0.71716  -39.32076 -3.52504  1.000 19.79830  ? 147 GLU B CD  1 
ATOM   2058 O  OE1 . GLU B 1 111 ? -1.76685  -38.66183 -3.31593  1.000 17.59419  ? 147 GLU B OE1 1 
ATOM   2059 O  OE2 . GLU B 1 111 ? 0.29596   -38.86746 -4.12460  1.000 15.19517  ? 147 GLU B OE2 1 
ATOM   2060 N  N   . GLN B 1 112 ? -0.24208  -43.00404 1.34610   1.000 13.52355  ? 148 GLN B N   1 
ATOM   2061 C  CA  . GLN B 1 112 ? -0.60586  -43.25621 2.73815   1.000 16.09643  ? 148 GLN B CA  1 
ATOM   2062 C  C   . GLN B 1 112 ? 0.10134   -42.35932 3.73829   1.000 14.05600  ? 148 GLN B C   1 
ATOM   2063 O  O   . GLN B 1 112 ? -0.21992  -42.42923 4.92466   1.000 16.79723  ? 148 GLN B O   1 
ATOM   2064 C  CB  . GLN B 1 112 ? -0.31486  -44.71616 3.10530   1.000 16.26318  ? 148 GLN B CB  1 
ATOM   2065 C  CG  . GLN B 1 112 ? -1.16167  -45.67588 2.26686   1.000 20.42723  ? 148 GLN B CG  1 
ATOM   2066 C  CD  . GLN B 1 112 ? -0.81504  -47.12731 2.49977   1.000 36.32569  ? 148 GLN B CD  1 
ATOM   2067 O  OE1 . GLN B 1 112 ? 0.28628   -47.56942 2.17096   1.000 31.81171  ? 148 GLN B OE1 1 
ATOM   2068 N  NE2 . GLN B 1 112 ? -1.74906  -47.87700 3.07995   1.000 39.94008  ? 148 GLN B NE2 1 
ATOM   2069 N  N   . CYS B 1 113 ? 1.06851   -41.55479 3.31028   1.000 14.23229  ? 149 CYS B N   1 
ATOM   2070 C  CA  . CYS B 1 113 ? 1.86481   -40.74707 4.22903   1.000 14.26297  ? 149 CYS B CA  1 
ATOM   2071 C  C   . CYS B 1 113 ? 1.62668   -39.26611 3.96801   1.000 15.98369  ? 149 CYS B C   1 
ATOM   2072 O  O   . CYS B 1 113 ? 1.32201   -38.87372 2.84370   1.000 16.34286  ? 149 CYS B O   1 
ATOM   2073 C  CB  . CYS B 1 113 ? 3.34671   -41.08262 4.05487   1.000 15.10009  ? 149 CYS B CB  1 
ATOM   2074 S  SG  . CYS B 1 113 ? 3.71534   -42.75687 4.61967   1.000 17.90546  ? 149 CYS B SG  1 
ATOM   2075 N  N   . VAL B 1 114 ? 1.77441   -38.41810 4.99041   1.000 12.48108  ? 150 VAL B N   1 
ATOM   2076 C  CA  . VAL B 1 114 ? 1.36212   -37.02078 4.85561   1.000 13.96726  ? 150 VAL B CA  1 
ATOM   2077 C  C   . VAL B 1 114 ? 2.58002   -36.10659 4.88198   1.000 14.89443  ? 150 VAL B C   1 
ATOM   2078 O  O   . VAL B 1 114 ? 3.42001   -36.20762 5.78602   1.000 13.67591  ? 150 VAL B O   1 
ATOM   2079 C  CB  . VAL B 1 114 ? 0.35488   -36.61931 5.94527   1.000 13.63828  ? 150 VAL B CB  1 
ATOM   2080 C  CG1 . VAL B 1 114 ? -0.03541  -35.15080 5.77493   1.000 12.57231  ? 150 VAL B CG1 1 
ATOM   2081 C  CG2 . VAL B 1 114 ? -0.88789  -37.51465 5.85629   1.000 14.46052  ? 150 VAL B CG2 1 
ATOM   2082 N  N   . GLU B 1 115 ? 2.66969   -35.21922 3.88689   1.000 13.38918  ? 151 GLU B N   1 
ATOM   2083 C  CA  . GLU B 1 115 ? 3.64011   -34.13088 3.89045   1.000 12.97421  ? 151 GLU B CA  1 
ATOM   2084 C  C   . GLU B 1 115 ? 2.91297   -32.80318 4.07028   1.000 13.96509  ? 151 GLU B C   1 
ATOM   2085 O  O   . GLU B 1 115 ? 1.73945   -32.65696 3.70979   1.000 14.92849  ? 151 GLU B O   1 
ATOM   2086 C  CB  . GLU B 1 115 ? 4.43445   -34.06164 2.57559   1.000 15.16485  ? 151 GLU B CB  1 
ATOM   2087 C  CG  . GLU B 1 115 ? 3.50355   -33.90295 1.35503   1.000 15.95278  ? 151 GLU B CG  1 
ATOM   2088 C  CD  . GLU B 1 115 ? 4.24627   -33.73214 0.02641   1.000 17.69397  ? 151 GLU B CD  1 
ATOM   2089 O  OE1 . GLU B 1 115 ? 5.49555   -33.73053 0.02901   1.000 14.84241  ? 151 GLU B OE1 1 
ATOM   2090 O  OE2 . GLU B 1 115 ? 3.57636   -33.59370 -1.03975  1.000 19.64607  ? 151 GLU B OE2 1 
ATOM   2091 N  N   . GLN B 1 116 ? 3.62185   -31.82170 4.63103   1.000 12.94338  ? 152 GLN B N   1 
ATOM   2092 C  CA  . GLN B 1 116 ? 3.22645   -30.42580 4.48867   1.000 14.19141  ? 152 GLN B CA  1 
ATOM   2093 C  C   . GLN B 1 116 ? 3.85265   -29.92543 3.19489   1.000 16.24973  ? 152 GLN B C   1 
ATOM   2094 O  O   . GLN B 1 116 ? 5.08345   -29.93259 3.07487   1.000 15.58623  ? 152 GLN B O   1 
ATOM   2095 C  CB  . GLN B 1 116 ? 3.73989   -29.60141 5.67235   1.000 13.81902  ? 152 GLN B CB  1 
ATOM   2096 C  CG  . GLN B 1 116 ? 3.70480   -28.08846 5.43098   1.000 15.45760  ? 152 GLN B CG  1 
ATOM   2097 C  CD  . GLN B 1 116 ? 2.29044   -27.53068 5.51083   1.000 17.81553  ? 152 GLN B CD  1 
ATOM   2098 O  OE1 . GLN B 1 116 ? 1.36860   -28.21938 5.97200   1.000 15.00413  ? 152 GLN B OE1 1 
ATOM   2099 N  NE2 . GLN B 1 116 ? 2.10571   -26.28705 5.05539   1.000 19.28726  ? 152 GLN B NE2 1 
ATOM   2100 N  N   . ILE B 1 117 ? 3.02001   -29.51390 2.19964   1.000 15.73287  ? 153 ILE B N   1 
ATOM   2101 C  CA  . ILE B 1 117 ? 3.58161   -29.01465 0.94619   1.000 17.91984  ? 153 ILE B CA  1 
ATOM   2102 C  C   . ILE B 1 117 ? 3.76962   -27.51631 1.04437   1.000 23.13404  ? 153 ILE B C   1 
ATOM   2103 O  O   . ILE B 1 117 ? 2.96558   -26.79543 1.64622   1.000 23.45324  ? 153 ILE B O   1 
ATOM   2104 C  CB  . ILE B 1 117 ? 2.71377   -29.36154 -0.27869  1.000 26.01719  ? 153 ILE B CB  1 
ATOM   2105 C  CG1 . ILE B 1 117 ? 1.25317   -28.98825 -0.06642  1.000 30.75302  ? 153 ILE B CG1 1 
ATOM   2106 C  CG2 . ILE B 1 117 ? 2.79254   -30.80991 -0.57697  1.000 37.33480  ? 153 ILE B CG2 1 
ATOM   2107 C  CD1 . ILE B 1 117 ? 0.55885   -28.59512 -1.33144  1.000 39.82199  ? 153 ILE B CD1 1 
ATOM   2108 N  N   . ASP B 1 118 ? 4.84484   -27.03891 0.44471   1.000 21.25413  ? 154 ASP B N   1 
ATOM   2109 C  CA  . ASP B 1 118 ? 5.06910   -25.60694 0.36162   1.000 22.24888  ? 154 ASP B CA  1 
ATOM   2110 C  C   . ASP B 1 118 ? 5.34762   -25.31161 -1.09740  1.000 30.76793  ? 154 ASP B C   1 
ATOM   2111 O  O   . ASP B 1 118 ? 6.47832   -25.46354 -1.56563  1.000 31.70131  ? 154 ASP B O   1 
ATOM   2112 C  CB  . ASP B 1 118 ? 6.20338   -25.13911 1.24655   1.000 23.06332  ? 154 ASP B CB  1 
ATOM   2113 C  CG  . ASP B 1 118 ? 6.24345   -23.64032 1.33453   1.000 29.11415  ? 154 ASP B CG  1 
ATOM   2114 O  OD1 . ASP B 1 118 ? 5.32999   -23.06721 1.97878   1.000 29.36376  ? 154 ASP B OD1 1 
ATOM   2115 O  OD2 . ASP B 1 118 ? 7.15296   -23.03743 0.72582   1.000 26.87508  ? 154 ASP B OD2 1 
ATOM   2116 N  N   . ARG B 1 119 ? 4.29323   -24.94631 -1.80347  1.000 24.25490  ? 155 ARG B N   1 
ATOM   2117 C  CA  . ARG B 1 119 ? 4.36850   -24.55804 -3.19194  1.000 40.42765  ? 155 ARG B CA  1 
ATOM   2118 C  C   . ARG B 1 119 ? 3.82126   -23.15318 -3.25908  1.000 37.72944  ? 155 ARG B C   1 
ATOM   2119 O  O   . ARG B 1 119 ? 2.98748   -22.75380 -2.44174  1.000 34.24791  ? 155 ARG B O   1 
ATOM   2120 C  CB  . ARG B 1 119 ? 3.54604   -25.48198 -4.10469  1.000 45.65268  ? 155 ARG B CB  1 
ATOM   2121 C  CG  . ARG B 1 119 ? 3.99708   -26.92745 -4.08112  1.000 46.47354  ? 155 ARG B CG  1 
ATOM   2122 C  CD  . ARG B 1 119 ? 5.24511   -27.13496 -4.91913  1.000 65.07622  ? 155 ARG B CD  1 
ATOM   2123 N  NE  . ARG B 1 119 ? 6.10704   -28.16337 -4.34752  1.000 75.85328  ? 155 ARG B NE  1 
ATOM   2124 C  CZ  . ARG B 1 119 ? 7.25125   -27.91777 -3.72164  1.000 75.71835  ? 155 ARG B CZ  1 
ATOM   2125 N  NH1 . ARG B 1 119 ? 7.72191   -26.68624 -3.59775  1.000 72.67450  ? 155 ARG B NH1 1 
ATOM   2126 N  NH2 . ARG B 1 119 ? 7.94163   -28.93317 -3.20830  1.000 71.01517  ? 155 ARG B NH2 1 
ATOM   2127 N  N   . GLU B 1 120 ? 4.30283   -22.38418 -4.20514  1.000 50.00998  ? 156 GLU B N   1 
ATOM   2128 C  CA  . GLU B 1 120 ? 3.53994   -21.20145 -4.50603  1.000 54.90460  ? 156 GLU B CA  1 
ATOM   2129 C  C   . GLU B 1 120 ? 2.22695   -21.69946 -5.09050  1.000 52.43592  ? 156 GLU B C   1 
ATOM   2130 O  O   . GLU B 1 120 ? 2.23231   -22.62520 -5.90884  1.000 62.39009  ? 156 GLU B O   1 
ATOM   2131 C  CB  . GLU B 1 120 ? 4.28547   -20.31394 -5.47668  1.000 63.41468  ? 156 GLU B CB  1 
ATOM   2132 C  CG  . GLU B 1 120 ? 3.67608   -18.97854 -5.51074  1.000 72.41194  ? 156 GLU B CG  1 
ATOM   2133 C  CD  . GLU B 1 120 ? 4.21109   -18.07231 -4.40683  1.000 74.35446  ? 156 GLU B CD  1 
ATOM   2134 O  OE1 . GLU B 1 120 ? 5.43582   -18.10505 -4.15449  1.000 76.32603  ? 156 GLU B OE1 1 
ATOM   2135 O  OE2 . GLU B 1 120 ? 3.42038   -17.30265 -3.82092  1.000 71.83509  ? 156 GLU B OE2 1 
ATOM   2136 N  N   . ASP B 1 121 ? 1.11117   -21.16017 -4.59089  1.000 53.98089  ? 157 ASP B N   1 
ATOM   2137 C  CA  . ASP B 1 121 ? -0.25937  -21.50470 -4.98622  1.000 55.76835  ? 157 ASP B CA  1 
ATOM   2138 C  C   . ASP B 1 121 ? -0.87300  -22.62946 -4.15014  1.000 54.93092  ? 157 ASP B C   1 
ATOM   2139 O  O   . ASP B 1 121 ? -2.10138  -22.70091 -4.04359  1.000 41.50251  ? 157 ASP B O   1 
ATOM   2140 C  CB  . ASP B 1 121 ? -0.36007  -21.88055 -6.47395  1.000 59.23062  ? 157 ASP B CB  1 
ATOM   2141 C  CG  . ASP B 1 121 ? 0.06094   -20.75251 -7.39705  1.000 74.58778  ? 157 ASP B CG  1 
ATOM   2142 O  OD1 . ASP B 1 121 ? 0.42050   -19.66503 -6.89437  1.000 77.64063  ? 157 ASP B OD1 1 
ATOM   2143 O  OD2 . ASP B 1 121 ? 0.05498   -20.96472 -8.62893  1.000 77.38249  ? 157 ASP B OD2 1 
ATOM   2144 N  N   . LYS B 1 122 ? -0.06212  -23.50795 -3.55246  1.000 48.79966  ? 158 LYS B N   1 
ATOM   2145 C  CA  . LYS B 1 122 ? -0.59323  -24.63086 -2.77438  1.000 41.04871  ? 158 LYS B CA  1 
ATOM   2146 C  C   . LYS B 1 122 ? 0.23129   -24.83413 -1.51283  1.000 30.94317  ? 158 LYS B C   1 
ATOM   2147 O  O   . LYS B 1 122 ? 1.43300   -25.09494 -1.59861  1.000 30.51748  ? 158 LYS B O   1 
ATOM   2148 C  CB  . LYS B 1 122 ? -0.60476  -25.92577 -3.59094  1.000 40.94158  ? 158 LYS B CB  1 
ATOM   2149 C  CG  . LYS B 1 122 ? -1.84305  -26.78812 -3.35944  1.000 46.45242  ? 158 LYS B CG  1 
ATOM   2150 C  CD  . LYS B 1 122 ? -1.74466  -28.13174 -4.08262  1.000 48.03125  ? 158 LYS B CD  1 
ATOM   2151 C  CE  . LYS B 1 122 ? -2.70797  -29.16996 -3.48725  1.000 42.90224  ? 158 LYS B CE  1 
ATOM   2152 N  NZ  . LYS B 1 122 ? -2.12622  -30.54146 -3.53137  1.000 46.26971  ? 158 LYS B NZ  1 
ATOM   2153 N  N   . LYS B 1 123 ? -0.41492  -24.72985 -0.35384  1.000 30.54216  ? 159 LYS B N   1 
ATOM   2154 C  CA  . LYS B 1 123 ? 0.21722   -25.01240 0.92603   1.000 26.70474  ? 159 LYS B CA  1 
ATOM   2155 C  C   . LYS B 1 123 ? -0.73141  -25.84491 1.77576   1.000 25.39184  ? 159 LYS B C   1 
ATOM   2156 O  O   . LYS B 1 123 ? -1.95255  -25.72257 1.66923   1.000 26.64215  ? 159 LYS B O   1 
ATOM   2157 C  CB  . LYS B 1 123 ? 0.57508   -23.72215 1.69096   1.000 33.10840  ? 159 LYS B CB  1 
ATOM   2158 C  CG  . LYS B 1 123 ? 1.73686   -22.94064 1.09058   1.000 39.17555  ? 159 LYS B CG  1 
ATOM   2159 C  CD  . LYS B 1 123 ? 1.69954   -21.47895 1.53599   1.000 45.87395  ? 159 LYS B CD  1 
ATOM   2160 C  CE  . LYS B 1 123 ? 2.13481   -20.53148 0.41118   1.000 43.11671  ? 159 LYS B CE  1 
ATOM   2161 N  NZ  . LYS B 1 123 ? 3.38001   -20.98130 -0.26726  1.000 48.21865  ? 159 LYS B NZ  1 
ATOM   2162 N  N   . GLY B 1 124 ? -0.15848  -26.67668 2.63876   1.000 16.72919  ? 160 GLY B N   1 
ATOM   2163 C  CA  . GLY B 1 124 ? -0.94813  -27.41852 3.60262   1.000 18.49222  ? 160 GLY B CA  1 
ATOM   2164 C  C   . GLY B 1 124 ? -0.67283  -28.89783 3.43649   1.000 18.21715  ? 160 GLY B C   1 
ATOM   2165 O  O   . GLY B 1 124 ? 0.27097   -29.27619 2.73182   1.000 18.54781  ? 160 GLY B O   1 
ATOM   2166 N  N   . TRP B 1 125 ? -1.48321  -29.74939 4.04391   1.000 16.05334  ? 161 TRP B N   1 
ATOM   2167 C  CA  . TRP B 1 125 ? -1.11491  -31.15812 4.04997   1.000 13.34297  ? 161 TRP B CA  1 
ATOM   2168 C  C   . TRP B 1 125 ? -1.47895  -31.81096 2.72729   1.000 17.21122  ? 161 TRP B C   1 
ATOM   2169 O  O   . TRP B 1 125 ? -2.45734  -31.43235 2.06561   1.000 15.54328  ? 161 TRP B O   1 
ATOM   2170 C  CB  . TRP B 1 125 ? -1.81366  -31.92677 5.16450   1.000 15.28610  ? 161 TRP B CB  1 
ATOM   2171 C  CG  . TRP B 1 125 ? -1.62879  -31.40465 6.55681   1.000 16.01861  ? 161 TRP B CG  1 
ATOM   2172 C  CD1 . TRP B 1 125 ? -0.68109  -30.51665 7.03331   1.000 16.14925  ? 161 TRP B CD1 1 
ATOM   2173 C  CD2 . TRP B 1 125 ? -2.40814  -31.80422 7.67672   1.000 17.43072  ? 161 TRP B CD2 1 
ATOM   2174 N  NE1 . TRP B 1 125 ? -0.85331  -30.34182 8.40749   1.000 16.14519  ? 161 TRP B NE1 1 
ATOM   2175 C  CE2 . TRP B 1 125 ? -1.91575  -31.11395 8.81195   1.000 18.25181  ? 161 TRP B CE2 1 
ATOM   2176 C  CE3 . TRP B 1 125 ? -3.49430  -32.68202 7.82823   1.000 19.31564  ? 161 TRP B CE3 1 
ATOM   2177 C  CZ2 . TRP B 1 125 ? -2.47696  -31.27603 10.08111  1.000 17.46719  ? 161 TRP B CZ2 1 
ATOM   2178 C  CZ3 . TRP B 1 125 ? -4.05699  -32.83665 9.09533   1.000 16.20300  ? 161 TRP B CZ3 1 
ATOM   2179 C  CH2 . TRP B 1 125 ? -3.54123  -32.14460 10.20231  1.000 20.25999  ? 161 TRP B CH2 1 
ATOM   2180 N  N   . ASN B 1 126 ? -0.68639  -32.81630 2.36049   1.000 13.71123  ? 162 ASN B N   1 
ATOM   2181 C  CA  . ASN B 1 126 ? -0.91871  -33.57950 1.14640   1.000 14.11601  ? 162 ASN B CA  1 
ATOM   2182 C  C   . ASN B 1 126 ? -0.61007  -35.04183 1.42851   1.000 15.14847  ? 162 ASN B C   1 
ATOM   2183 O  O   . ASN B 1 126 ? 0.41977   -35.33535 2.04180   1.000 13.65985  ? 162 ASN B O   1 
ATOM   2184 C  CB  . ASN B 1 126 ? -0.01240  -33.08618 0.01243   1.000 14.70745  ? 162 ASN B CB  1 
ATOM   2185 C  CG  . ASN B 1 126 ? -0.10911  -33.98124 -1.18365  1.000 15.26374  ? 162 ASN B CG  1 
ATOM   2186 O  OD1 . ASN B 1 126 ? -1.21805  -34.33958 -1.57927  1.000 16.27862  ? 162 ASN B OD1 1 
ATOM   2187 N  ND2 . ASN B 1 126 ? 1.03292   -34.38922 -1.74786  1.000 13.64474  ? 162 ASN B ND2 1 
ATOM   2188 N  N   . ASP B 1 127 ? -1.48425  -35.96685 1.00643   1.000 13.02260  ? 163 ASP B N   1 
ATOM   2189 C  CA  . ASP B 1 127 ? -1.08450  -37.36530 1.06419   1.000 11.85846  ? 163 ASP B CA  1 
ATOM   2190 C  C   . ASP B 1 127 ? -0.14867  -37.65859 -0.10925  1.000 12.42821  ? 163 ASP B C   1 
ATOM   2191 O  O   . ASP B 1 127 ? -0.38891  -37.19615 -1.22725  1.000 13.74883  ? 163 ASP B O   1 
ATOM   2192 C  CB  . ASP B 1 127 ? -2.29429  -38.32120 1.04442   1.000 15.16975  ? 163 ASP B CB  1 
ATOM   2193 C  CG  . ASP B 1 127 ? -3.22461  -38.15506 -0.17416  1.000 17.61589  ? 163 ASP B CG  1 
ATOM   2194 O  OD1 . ASP B 1 127 ? -3.32765  -37.07201 -0.77887  1.000 15.03960  ? 163 ASP B OD1 1 
ATOM   2195 O  OD2 . ASP B 1 127 ? -3.91518  -39.15383 -0.48290  1.000 15.05371  ? 163 ASP B OD2 1 
ATOM   2196 N  N   . LEU B 1 128 ? 0.90958   -38.42724 0.15146   1.000 14.72631  ? 164 LEU B N   1 
ATOM   2197 C  CA  . LEU B 1 128 ? 1.91601   -38.72365 -0.86838  1.000 12.96584  ? 164 LEU B CA  1 
ATOM   2198 C  C   . LEU B 1 128 ? 2.39191   -40.16739 -0.73474  1.000 14.23250  ? 164 LEU B C   1 
ATOM   2199 O  O   . LEU B 1 128 ? 2.31640   -40.77848 0.33340   1.000 15.68242  ? 164 LEU B O   1 
ATOM   2200 C  CB  . LEU B 1 128 ? 3.11094   -37.75321 -0.74407  1.000 16.06220  ? 164 LEU B CB  1 
ATOM   2201 C  CG  . LEU B 1 128 ? 4.17878   -37.78087 -1.83545  1.000 15.08123  ? 164 LEU B CG  1 
ATOM   2202 C  CD1 . LEU B 1 128 ? 3.54628   -37.28852 -3.14588  1.000 16.32315  ? 164 LEU B CD1 1 
ATOM   2203 C  CD2 . LEU B 1 128 ? 5.37688   -36.88443 -1.42173  1.000 17.23813  ? 164 LEU B CD2 1 
ATOM   2204 N  N   . VAL B 1 129 ? 2.88945   -40.71310 -1.84637  1.000 15.80834  ? 165 VAL B N   1 
ATOM   2205 C  CA  . VAL B 1 129 ? 3.53631   -42.02782 -1.81153  1.000 15.72815  ? 165 VAL B CA  1 
ATOM   2206 C  C   . VAL B 1 129 ? 4.61762   -42.05451 -0.73710  1.000 15.44888  ? 165 VAL B C   1 
ATOM   2207 O  O   . VAL B 1 129 ? 5.54853   -41.23951 -0.75663  1.000 16.05369  ? 165 VAL B O   1 
ATOM   2208 C  CB  . VAL B 1 129 ? 4.11746   -42.35203 -3.19766  1.000 16.08281  ? 165 VAL B CB  1 
ATOM   2209 C  CG1 . VAL B 1 129 ? 4.74813   -43.75716 -3.19782  1.000 17.82919  ? 165 VAL B CG1 1 
ATOM   2210 C  CG2 . VAL B 1 129 ? 3.00215   -42.23771 -4.25691  1.000 20.21859  ? 165 VAL B CG2 1 
ATOM   2211 N  N   . CYS B 1 130 ? 4.51697   -43.02441 0.18033   1.000 16.37421  ? 166 CYS B N   1 
ATOM   2212 C  CA  . CYS B 1 130 ? 5.40141   -43.05987 1.34671   1.000 17.53774  ? 166 CYS B CA  1 
ATOM   2213 C  C   . CYS B 1 130 ? 6.85520   -43.23209 0.95604   1.000 17.68880  ? 166 CYS B C   1 
ATOM   2214 O  O   . CYS B 1 130 ? 7.74371   -42.83563 1.71846   1.000 17.05070  ? 166 CYS B O   1 
ATOM   2215 C  CB  . CYS B 1 130 ? 5.02809   -44.20366 2.28798   1.000 18.83525  ? 166 CYS B CB  1 
ATOM   2216 S  SG  . CYS B 1 130 ? 3.38752   -44.02386 3.04690   1.000 22.57335  ? 166 CYS B SG  1 
ATOM   2217 N  N   . GLU B 1 131 ? 7.11027   -43.87936 -0.18610  1.000 17.32719  ? 167 GLU B N   1 
ATOM   2218 C  CA  . GLU B 1 131 ? 8.46876   -44.15179 -0.65590  1.000 19.06087  ? 167 GLU B CA  1 
ATOM   2219 C  C   . GLU B 1 131 ? 9.11952   -42.96726 -1.35734  1.000 15.32088  ? 167 GLU B C   1 
ATOM   2220 O  O   . GLU B 1 131 ? 10.31180  -43.05589 -1.69711  1.000 16.95160  ? 167 GLU B O   1 
ATOM   2221 C  CB  . GLU B 1 131 ? 8.44940   -45.36056 -1.60361  1.000 22.22517  ? 167 GLU B CB  1 
ATOM   2222 C  CG  . GLU B 1 131 ? 8.10683   -46.67019 -0.88824  1.000 28.62960  ? 167 GLU B CG  1 
ATOM   2223 C  CD  . GLU B 1 131 ? 6.63133   -46.77939 -0.49864  1.000 41.63932  ? 167 GLU B CD  1 
ATOM   2224 O  OE1 . GLU B 1 131 ? 6.34017   -47.46964 0.50972   1.000 49.43172  ? 167 GLU B OE1 1 
ATOM   2225 O  OE2 . GLU B 1 131 ? 5.77238   -46.16292 -1.17132  1.000 37.52796  ? 167 GLU B OE2 1 
ATOM   2226 N  N   . PHE B 1 132 ? 8.37780   -41.88689 -1.60864  1.000 15.09621  ? 168 PHE B N   1 
ATOM   2227 C  CA  . PHE B 1 132 ? 8.98037   -40.64872 -2.10313  1.000 13.97381  ? 168 PHE B CA  1 
ATOM   2228 C  C   . PHE B 1 132 ? 9.77663   -40.01998 -0.96337  1.000 15.19446  ? 168 PHE B C   1 
ATOM   2229 O  O   . PHE B 1 132 ? 9.62860   -40.40288 0.19769   1.000 16.54443  ? 168 PHE B O   1 
ATOM   2230 C  CB  . PHE B 1 132 ? 7.91871   -39.65688 -2.58942  1.000 15.87048  ? 168 PHE B CB  1 
ATOM   2231 C  CG  . PHE B 1 132 ? 7.21870   -40.06461 -3.88775  1.000 18.70293  ? 168 PHE B CG  1 
ATOM   2232 C  CD1 . PHE B 1 132 ? 7.48829   -41.28162 -4.49078  1.000 23.70231  ? 168 PHE B CD1 1 
ATOM   2233 C  CD2 . PHE B 1 132 ? 6.26680   -39.22674 -4.45590  1.000 24.88209  ? 168 PHE B CD2 1 
ATOM   2234 C  CE1 . PHE B 1 132 ? 6.83501   -41.65881 -5.66754  1.000 25.59169  ? 168 PHE B CE1 1 
ATOM   2235 C  CE2 . PHE B 1 132 ? 5.60065   -39.58928 -5.63624  1.000 28.19889  ? 168 PHE B CE2 1 
ATOM   2236 C  CZ  . PHE B 1 132 ? 5.89039   -40.80822 -6.24251  1.000 26.86945  ? 168 PHE B CZ  1 
ATOM   2237 N  N   . SER B 1 133 ? 10.64648  -39.07723 -1.30522  1.000 16.63799  ? 169 SER B N   1 
ATOM   2238 C  CA  . SER B 1 133 ? 11.52870  -38.48588 -0.31204  1.000 18.09185  ? 169 SER B CA  1 
ATOM   2239 C  C   . SER B 1 133 ? 11.22985  -37.00981 -0.07733  1.000 15.74924  ? 169 SER B C   1 
ATOM   2240 O  O   . SER B 1 133 ? 10.90293  -36.26272 -1.00020  1.000 16.27729  ? 169 SER B O   1 
ATOM   2241 C  CB  . SER B 1 133 ? 12.99411  -38.65993 -0.73025  1.000 16.19142  ? 169 SER B CB  1 
ATOM   2242 O  OG  . SER B 1 133 ? 13.40376  -39.98222 -0.37646  1.000 18.58908  ? 169 SER B OG  1 
ATOM   2243 N  N   . ASN B 1 134 ? 11.40863  -36.59449 1.17714   1.000 12.90305  ? 170 ASN B N   1 
ATOM   2244 C  CA  . ASN B 1 134 ? 11.22621  -35.21222 1.60130   1.000 14.15867  ? 170 ASN B CA  1 
ATOM   2245 C  C   . ASN B 1 134 ? 12.16187  -34.95293 2.77211   1.000 14.10345  ? 170 ASN B C   1 
ATOM   2246 O  O   . ASN B 1 134 ? 12.50912  -35.87773 3.51948   1.000 14.34877  ? 170 ASN B O   1 
ATOM   2247 C  CB  . ASN B 1 134 ? 9.80475   -34.95259 2.14428   1.000 15.66037  ? 170 ASN B CB  1 
ATOM   2248 C  CG  . ASN B 1 134 ? 8.79936   -34.66017 1.06668   1.000 15.89100  ? 170 ASN B CG  1 
ATOM   2249 O  OD1 . ASN B 1 134 ? 9.06073   -33.89845 0.13478   1.000 15.54736  ? 170 ASN B OD1 1 
ATOM   2250 N  ND2 . ASN B 1 134 ? 7.59004   -35.21794 1.23807   1.000 15.33931  ? 170 ASN B ND2 1 
ATOM   2251 N  N   . PHE B 1 135 ? 12.46956  -33.67116 3.00248   1.000 13.46708  ? 171 PHE B N   1 
ATOM   2252 C  CA  . PHE B 1 135 ? 12.93556  -33.29453 4.33428   1.000 10.86892  ? 171 PHE B CA  1 
ATOM   2253 C  C   . PHE B 1 135 ? 11.86893  -33.66676 5.36137   1.000 14.33740  ? 171 PHE B C   1 
ATOM   2254 O  O   . PHE B 1 135 ? 10.69912  -33.84115 5.02333   1.000 13.94156  ? 171 PHE B O   1 
ATOM   2255 C  CB  . PHE B 1 135 ? 13.19449  -31.79431 4.40596   1.000 12.01946  ? 171 PHE B CB  1 
ATOM   2256 C  CG  . PHE B 1 135 ? 14.33890  -31.35923 3.52759   1.000 15.11132  ? 171 PHE B CG  1 
ATOM   2257 C  CD1 . PHE B 1 135 ? 15.62667  -31.84845 3.75123   1.000 14.70148  ? 171 PHE B CD1 1 
ATOM   2258 C  CD2 . PHE B 1 135 ? 14.12124  -30.47391 2.48749   1.000 18.28780  ? 171 PHE B CD2 1 
ATOM   2259 C  CE1 . PHE B 1 135 ? 16.68343  -31.45827 2.92757   1.000 17.01575  ? 171 PHE B CE1 1 
ATOM   2260 C  CE2 . PHE B 1 135 ? 15.17849  -30.06816 1.67207   1.000 21.22294  ? 171 PHE B CE2 1 
ATOM   2261 C  CZ  . PHE B 1 135 ? 16.45642  -30.56770 1.90452   1.000 17.33073  ? 171 PHE B CZ  1 
ATOM   2262 N  N   . TYR B 1 136 ? 12.26766  -33.76202 6.63551   1.000 12.53459  ? 172 TYR B N   1 
ATOM   2263 C  CA  . TYR B 1 136 ? 11.30897  -34.16697 7.65408   1.000 14.24969  ? 172 TYR B CA  1 
ATOM   2264 C  C   . TYR B 1 136 ? 11.52233  -33.36216 8.91650   1.000 13.71970  ? 172 TYR B C   1 
ATOM   2265 O  O   . TYR B 1 136 ? 12.59949  -32.81576 9.14984   1.000 16.23122  ? 172 TYR B O   1 
ATOM   2266 C  CB  . TYR B 1 136 ? 11.39597  -35.65546 8.00324   1.000 14.18894  ? 172 TYR B CB  1 
ATOM   2267 C  CG  . TYR B 1 136 ? 12.78509  -36.18451 8.30261   1.000 15.08019  ? 172 TYR B CG  1 
ATOM   2268 C  CD1 . TYR B 1 136 ? 13.64860  -36.52892 7.25916   1.000 15.59692  ? 172 TYR B CD1 1 
ATOM   2269 C  CD2 . TYR B 1 136 ? 13.23394  -36.33659 9.61448   1.000 12.47292  ? 172 TYR B CD2 1 
ATOM   2270 C  CE1 . TYR B 1 136 ? 14.92920  -37.04591 7.50633   1.000 16.40644  ? 172 TYR B CE1 1 
ATOM   2271 C  CE2 . TYR B 1 136 ? 14.52609  -36.84965 9.87854   1.000 13.39596  ? 172 TYR B CE2 1 
ATOM   2272 C  CZ  . TYR B 1 136 ? 15.35612  -37.19683 8.81224   1.000 18.82126  ? 172 TYR B CZ  1 
ATOM   2273 O  OH  . TYR B 1 136 ? 16.61882  -37.70010 9.02797   1.000 19.63818  ? 172 TYR B OH  1 
ATOM   2274 N  N   . MET B 1 137 ? 10.46862  -33.30889 9.73040   1.000 14.62043  ? 173 MET B N   1 
ATOM   2275 C  CA  A MET B 1 137 ? 10.50195  -32.61941 11.01395  0.743 15.71334  ? 173 MET B CA  1 
ATOM   2276 C  CA  B MET B 1 137 ? 10.48990  -32.61589 11.01240  0.257 15.61537  ? 173 MET B CA  1 
ATOM   2277 C  C   . MET B 1 137 ? 10.16942  -33.60454 12.12459  1.000 14.99148  ? 173 MET B C   1 
ATOM   2278 O  O   . MET B 1 137 ? 9.12631   -34.26462 12.07408  1.000 14.92293  ? 173 MET B O   1 
ATOM   2279 C  CB  A MET B 1 137 ? 9.50752   -31.45778 11.03336  0.743 15.15694  ? 173 MET B CB  1 
ATOM   2280 C  CB  B MET B 1 137 ? 9.47637   -31.47279 11.02007  0.257 15.13216  ? 173 MET B CB  1 
ATOM   2281 C  CG  A MET B 1 137 ? 9.50252   -30.72882 12.37050  0.743 15.33750  ? 173 MET B CG  1 
ATOM   2282 C  CG  B MET B 1 137 ? 9.29009   -30.84780 12.38483  0.257 15.05850  ? 173 MET B CG  1 
ATOM   2283 S  SD  A MET B 1 137 ? 8.25556   -29.43609 12.36733  0.743 17.51958  ? 173 MET B SD  1 
ATOM   2284 S  SD  B MET B 1 137 ? 10.30769  -29.37673 12.51552  0.257 22.55478  ? 173 MET B SD  1 
ATOM   2285 C  CE  A MET B 1 137 ? 9.26503   -28.06404 11.83839  0.743 19.98065  ? 173 MET B CE  1 
ATOM   2286 C  CE  B MET B 1 137 ? 9.19969   -28.16513 11.80788  0.257 19.88144  ? 173 MET B CE  1 
ATOM   2287 N  N   . CYS B 1 138 ? 11.06779  -33.70755 13.11828  1.000 15.06946  ? 174 CYS B N   1 
ATOM   2288 C  CA  . CYS B 1 138 ? 10.82857  -34.47833 14.33330  1.000 15.03176  ? 174 CYS B CA  1 
ATOM   2289 C  C   . CYS B 1 138 ? 10.26281  -33.55621 15.40652  1.000 14.84969  ? 174 CYS B C   1 
ATOM   2290 O  O   . CYS B 1 138 ? 10.54478  -32.35424 15.42841  1.000 15.79000  ? 174 CYS B O   1 
ATOM   2291 C  CB  . CYS B 1 138 ? 12.12835  -35.08187 14.87540  1.000 18.36746  ? 174 CYS B CB  1 
ATOM   2292 S  SG  . CYS B 1 138 ? 13.04502  -36.14195 13.73771  1.000 19.52669  ? 174 CYS B SG  1 
ATOM   2293 N  N   . GLU B 1 139 ? 9.48726   -34.12824 16.32511  1.000 15.97407  ? 175 GLU B N   1 
ATOM   2294 C  CA  . GLU B 1 139 ? 9.02565   -33.35765 17.46822  1.000 14.45812  ? 175 GLU B CA  1 
ATOM   2295 C  C   . GLU B 1 139 ? 9.15301   -34.20123 18.72646  1.000 15.99029  ? 175 GLU B C   1 
ATOM   2296 O  O   . GLU B 1 139 ? 8.76229   -35.36905 18.73205  1.000 14.30055  ? 175 GLU B O   1 
ATOM   2297 C  CB  . GLU B 1 139 ? 7.55528   -32.92878 17.31207  1.000 19.70821  ? 175 GLU B CB  1 
ATOM   2298 C  CG  . GLU B 1 139 ? 7.03981   -32.14310 18.53605  1.000 17.81400  ? 175 GLU B CG  1 
ATOM   2299 C  CD  . GLU B 1 139 ? 5.54604   -31.83499 18.46555  1.000 18.82972  ? 175 GLU B CD  1 
ATOM   2300 O  OE1 . GLU B 1 139 ? 4.86781   -32.33232 17.53713  1.000 18.80009  ? 175 GLU B OE1 1 
ATOM   2301 O  OE2 . GLU B 1 139 ? 5.04710   -31.07733 19.32913  1.000 18.48867  ? 175 GLU B OE2 1 
ATOM   2302 N  N   . LYS B 1 140 ? 9.63131   -33.58760 19.81036  1.000 14.69933  ? 176 LYS B N   1 
ATOM   2303 C  CA  . LYS B 1 140 ? 9.75531   -34.27405 21.09191  1.000 18.01279  ? 176 LYS B CA  1 
ATOM   2304 C  C   . LYS B 1 140 ? 9.07537   -33.38295 22.12113  1.000 18.62554  ? 176 LYS B C   1 
ATOM   2305 O  O   . LYS B 1 140 ? 9.43654   -32.21233 22.24971  1.000 20.56845  ? 176 LYS B O   1 
ATOM   2306 C  CB  . LYS B 1 140 ? 11.24230  -34.48909 21.42024  1.000 19.69822  ? 176 LYS B CB  1 
ATOM   2307 C  CG  . LYS B 1 140 ? 11.63011  -34.97459 22.81027  1.000 33.58098  ? 176 LYS B CG  1 
ATOM   2308 C  CD  . LYS B 1 140 ? 11.19704  -36.43622 22.96246  1.000 32.04411  ? 176 LYS B CD  1 
ATOM   2309 C  CE  . LYS B 1 140 ? 11.32570  -36.94225 24.38931  1.000 43.02120  ? 176 LYS B CE  1 
ATOM   2310 N  NZ  . LYS B 1 140 ? 12.65745  -36.55299 24.91716  1.000 51.44889  ? 176 LYS B NZ  1 
ATOM   2311 N  N   . ARG B 1 141 ? 8.02499   -33.88522 22.77179  1.000 19.63448  ? 177 ARG B N   1 
ATOM   2312 C  CA  . ARG B 1 141 ? 7.42895   -33.10751 23.85127  1.000 21.46929  ? 177 ARG B CA  1 
ATOM   2313 C  C   . ARG B 1 141 ? 8.39720   -33.12592 25.02116  1.000 23.71614  ? 177 ARG B C   1 
ATOM   2314 O  O   . ARG B 1 141 ? 8.83124   -34.19188 25.45833  1.000 34.74692  ? 177 ARG B O   1 
ATOM   2315 C  CB  . ARG B 1 141 ? 6.07151   -33.68022 24.27365  1.000 23.43314  ? 177 ARG B CB  1 
ATOM   2316 C  CG  . ARG B 1 141 ? 4.94722   -33.54012 23.27717  1.000 35.23468  ? 177 ARG B CG  1 
ATOM   2317 C  CD  . ARG B 1 141 ? 4.62112   -32.09102 23.01443  1.000 42.71001  ? 177 ARG B CD  1 
ATOM   2318 N  NE  . ARG B 1 141 ? 3.79791   -31.46727 24.04487  1.000 55.85436  ? 177 ARG B NE  1 
ATOM   2319 C  CZ  . ARG B 1 141 ? 3.54309   -30.16507 24.11049  1.000 67.66696  ? 177 ARG B CZ  1 
ATOM   2320 N  NH1 . ARG B 1 141 ? 4.10058   -29.30477 23.26829  1.000 58.08411  ? 177 ARG B NH1 1 
ATOM   2321 N  NH2 . ARG B 1 141 ? 2.70112   -29.71510 25.03676  1.000 66.22109  ? 177 ARG B NH2 1 
ATOM   2322 N  N   . ILE B 1 142 ? 8.76660   -31.95505 25.51425  1.000 30.99897  ? 178 ILE B N   1 
ATOM   2323 C  CA  . ILE B 1 142 ? 9.81405   -31.94350 26.52410  1.000 29.27224  ? 178 ILE B CA  1 
ATOM   2324 C  C   . ILE B 1 142 ? 9.22917   -31.66909 27.90115  1.000 41.29775  ? 178 ILE B C   1 
ATOM   2325 O  O   . ILE B 1 142 ? 9.72495   -32.20162 28.89978  1.000 33.35724  ? 178 ILE B O   1 
ATOM   2326 C  CB  . ILE B 1 142 ? 10.94709  -30.96934 26.13296  1.000 49.97563  ? 178 ILE B CB  1 
ATOM   2327 C  CG1 . ILE B 1 142 ? 12.21485  -31.26210 26.95415  1.000 56.09855  ? 178 ILE B CG1 1 
ATOM   2328 C  CG2 . ILE B 1 142 ? 10.47784  -29.51549 26.10409  1.000 46.13374  ? 178 ILE B CG2 1 
ATOM   2329 C  CD1 . ILE B 1 142 ? 12.83946  -32.61292 26.66653  1.000 55.12454  ? 178 ILE B CD1 1 
ATOM   2330 N  N   . PHE B 1 143 ? 8.13765   -30.91541 27.95629  1.000 44.57039  ? 179 PHE B N   1 
ATOM   2331 C  CA  . PHE B 1 143 ? 7.52308   -30.46562 29.19428  1.000 60.57125  ? 179 PHE B CA  1 
ATOM   2332 C  C   . PHE B 1 143 ? 6.10426   -31.00964 29.31561  1.000 64.34282  ? 179 PHE B C   1 
ATOM   2333 O  O   . PHE B 1 143 ? 5.53205   -31.49803 28.33369  1.000 71.02628  ? 179 PHE B O   1 
ATOM   2334 C  CB  . PHE B 1 143 ? 7.50557   -28.92982 29.25367  1.000 57.88654  ? 179 PHE B CB  1 
ATOM   2335 C  CG  . PHE B 1 143 ? 8.87351   -28.31524 29.27295  1.000 60.48908  ? 179 PHE B CG  1 
ATOM   2336 C  CD1 . PHE B 1 143 ? 9.82286   -28.73920 30.19002  1.000 61.76250  ? 179 PHE B CD1 1 
ATOM   2337 C  CD2 . PHE B 1 143 ? 9.21878   -27.33297 28.35819  1.000 60.08874  ? 179 PHE B CD2 1 
ATOM   2338 C  CE1 . PHE B 1 143 ? 11.08550  -28.18491 30.20755  1.000 65.26917  ? 179 PHE B CE1 1 
ATOM   2339 C  CE2 . PHE B 1 143 ? 10.48268  -26.77484 28.36526  1.000 60.90227  ? 179 PHE B CE2 1 
ATOM   2340 C  CZ  . PHE B 1 143 ? 11.41774  -27.20471 29.29154  1.000 70.01564  ? 179 PHE B CZ  1 
ATOM   2341 N  N   . PRO B 1 144 ? 5.50928   -30.96723 30.52239  1.000 70.92336  ? 180 PRO B N   1 
ATOM   2342 C  CA  . PRO B 1 144 ? 4.12212   -31.41911 30.70538  1.000 75.95389  ? 180 PRO B CA  1 
ATOM   2343 C  C   . PRO B 1 144 ? 3.06899   -30.37047 30.33545  1.000 74.57872  ? 180 PRO B C   1 
ATOM   2344 O  O   . PRO B 1 144 ? 3.24418   -29.18402 30.61563  1.000 78.86036  ? 180 PRO B O   1 
ATOM   2345 C  CB  . PRO B 1 144 ? 4.05809   -31.73911 32.20139  1.000 78.32556  ? 180 PRO B CB  1 
ATOM   2346 C  CG  . PRO B 1 144 ? 5.07325   -30.84671 32.81459  1.000 77.44079  ? 180 PRO B CG  1 
ATOM   2347 C  CD  . PRO B 1 144 ? 6.18572   -30.73080 31.81251  1.000 67.16039  ? 180 PRO B CD  1 
ATOM   2348 N  N   . PHE C 1 11  ? 11.97746  15.65486  13.10686  1.000 72.08080  ? 47  PHE E N   1 
ATOM   2349 C  CA  . PHE C 1 11  ? 12.52394  14.59628  13.95050  1.000 77.91861  ? 47  PHE E CA  1 
ATOM   2350 C  C   . PHE C 1 11  ? 14.05416  14.67516  14.02810  1.000 71.64544  ? 47  PHE E C   1 
ATOM   2351 O  O   . PHE C 1 11  ? 14.64775  14.34835  15.05868  1.000 63.65700  ? 47  PHE E O   1 
ATOM   2352 C  CB  . PHE C 1 11  ? 12.06664  13.22490  13.44126  1.000 76.14968  ? 47  PHE E CB  1 
ATOM   2353 C  CG  . PHE C 1 11  ? 10.69344  12.82538  13.92580  1.000 65.47416  ? 47  PHE E CG  1 
ATOM   2354 C  CD1 . PHE C 1 11  ? 10.53438  12.17754  15.14043  1.000 63.84817  ? 47  PHE E CD1 1 
ATOM   2355 C  CD2 . PHE C 1 11  ? 9.56048   13.10985  13.17451  1.000 79.93864  ? 47  PHE E CD2 1 
ATOM   2356 C  CE1 . PHE C 1 11  ? 9.26856   11.80736  15.59668  1.000 65.37719  ? 47  PHE E CE1 1 
ATOM   2357 C  CE2 . PHE C 1 11  ? 8.28935   12.74393  13.62516  1.000 73.92754  ? 47  PHE E CE2 1 
ATOM   2358 C  CZ  . PHE C 1 11  ? 8.14466   12.09210  14.84011  1.000 43.36288  ? 47  PHE E CZ  1 
ATOM   2359 N  N   . ASP C 1 12  ? 14.69065  15.10987  12.93554  1.000 75.82297  ? 48  ASP E N   1 
ATOM   2360 C  CA  . ASP C 1 12  ? 16.10587  15.46733  13.00381  1.000 72.46853  ? 48  ASP E CA  1 
ATOM   2361 C  C   . ASP C 1 12  ? 16.31036  16.69556  13.87745  1.000 62.94157  ? 48  ASP E C   1 
ATOM   2362 O  O   . ASP C 1 12  ? 17.36848  16.85822  14.49589  1.000 65.81323  ? 48  ASP E O   1 
ATOM   2363 C  CB  . ASP C 1 12  ? 16.65428  15.73874  11.60274  1.000 81.70091  ? 48  ASP E CB  1 
ATOM   2364 C  CG  . ASP C 1 12  ? 16.31314  14.64231  10.61700  1.000 83.20828  ? 48  ASP E CG  1 
ATOM   2365 O  OD1 . ASP C 1 12  ? 16.27585  13.46152  11.02094  1.000 85.41865  ? 48  ASP E OD1 1 
ATOM   2366 O  OD2 . ASP C 1 12  ? 16.07111  14.96779  9.43539   1.000 88.17706  ? 48  ASP E OD2 1 
ATOM   2367 N  N   . LYS C 1 13  ? 15.30106  17.56395  13.92388  1.000 58.49961  ? 49  LYS E N   1 
ATOM   2368 C  CA  . LYS C 1 13  ? 15.30535  18.77691  14.72586  1.000 53.78763  ? 49  LYS E CA  1 
ATOM   2369 C  C   . LYS C 1 13  ? 15.28033  18.49984  16.22486  1.000 48.12308  ? 49  LYS E C   1 
ATOM   2370 O  O   . LYS C 1 13  ? 15.62030  19.39053  17.01086  1.000 43.11009  ? 49  LYS E O   1 
ATOM   2371 C  CB  . LYS C 1 13  ? 14.09340  19.61374  14.32408  1.000 57.88457  ? 49  LYS E CB  1 
ATOM   2372 C  CG  . LYS C 1 13  ? 12.79885  18.81305  14.42836  1.000 65.66562  ? 49  LYS E CG  1 
ATOM   2373 C  CD  . LYS C 1 13  ? 11.58870  19.67407  14.73566  1.000 69.84766  ? 49  LYS E CD  1 
ATOM   2374 C  CE  . LYS C 1 13  ? 10.88669  20.12809  13.45900  1.000 78.26074  ? 49  LYS E CE  1 
ATOM   2375 N  NZ  . LYS C 1 13  ? 10.13324  19.01509  12.79654  1.000 66.64551  ? 49  LYS E NZ  1 
ATOM   2376 N  N   . LEU C 1 14  ? 14.88657  17.29349  16.64042  1.000 45.27673  ? 50  LEU E N   1 
ATOM   2377 C  CA  . LEU C 1 14  ? 14.72235  16.99909  18.06049  1.000 36.77866  ? 50  LEU E CA  1 
ATOM   2378 C  C   . LEU C 1 14  ? 16.04019  16.71250  18.77375  1.000 31.02471  ? 50  LEU E C   1 
ATOM   2379 O  O   . LEU C 1 14  ? 16.09164  16.80760  20.00633  1.000 32.95441  ? 50  LEU E O   1 
ATOM   2380 C  CB  . LEU C 1 14  ? 13.78352  15.80390  18.23845  1.000 31.05367  ? 50  LEU E CB  1 
ATOM   2381 C  CG  . LEU C 1 14  ? 12.35552  15.91242  17.69314  1.000 33.76839  ? 50  LEU E CG  1 
ATOM   2382 C  CD1 . LEU C 1 14  ? 11.48622  14.76395  18.20437  1.000 34.29662  ? 50  LEU E CD1 1 
ATOM   2383 C  CD2 . LEU C 1 14  ? 11.73722  17.25416  18.05600  1.000 32.58035  ? 50  LEU E CD2 1 
ATOM   2384 N  N   . ASP C 1 15  ? 17.09746  16.36805  18.03524  1.000 28.13539  ? 51  ASP E N   1 
ATOM   2385 C  CA  . ASP C 1 15  ? 18.34132  15.92834  18.66434  1.000 32.21250  ? 51  ASP E CA  1 
ATOM   2386 C  C   . ASP C 1 15  ? 18.92274  16.93896  19.65346  1.000 37.31707  ? 51  ASP E C   1 
ATOM   2387 O  O   . ASP C 1 15  ? 19.31765  16.51474  20.75618  1.000 28.65445  ? 51  ASP E O   1 
ATOM   2388 C  CB  . ASP C 1 15  ? 19.36405  15.57259  17.57340  1.000 42.03414  ? 51  ASP E CB  1 
ATOM   2389 C  CG  . ASP C 1 15  ? 19.03389  14.26671  16.86349  1.000 62.08311  ? 51  ASP E CG  1 
ATOM   2390 O  OD1 . ASP C 1 15  ? 17.99386  13.65404  17.19117  1.000 66.88834  ? 51  ASP E OD1 1 
ATOM   2391 O  OD2 . ASP C 1 15  ? 19.79742  13.86437  15.95775  1.000 65.33806  ? 51  ASP E OD2 1 
ATOM   2392 N  N   . PRO C 1 16  ? 19.00990  18.24551  19.35379  1.000 32.68248  ? 52  PRO E N   1 
ATOM   2393 C  CA  . PRO C 1 16  ? 19.55127  19.17755  20.36308  1.000 33.61693  ? 52  PRO E CA  1 
ATOM   2394 C  C   . PRO C 1 16  ? 18.69968  19.26106  21.61275  1.000 29.68422  ? 52  PRO E C   1 
ATOM   2395 O  O   . PRO C 1 16  ? 19.23096  19.53149  22.69974  1.000 30.03106  ? 52  PRO E O   1 
ATOM   2396 C  CB  . PRO C 1 16  ? 19.59608  20.53148  19.63801  1.000 32.23230  ? 52  PRO E CB  1 
ATOM   2397 C  CG  . PRO C 1 16  ? 19.30946  20.27596  18.21723  1.000 40.02104  ? 52  PRO E CG  1 
ATOM   2398 C  CD  . PRO C 1 16  ? 18.79345  18.88842  18.04179  1.000 41.80091  ? 52  PRO E CD  1 
ATOM   2399 N  N   . TYR C 1 17  ? 17.38730  19.05579  21.48069  1.000 27.09519  ? 53  TYR E N   1 
ATOM   2400 C  CA  . TYR C 1 17  ? 16.51318  18.99193  22.64562  1.000 24.69688  ? 53  TYR E CA  1 
ATOM   2401 C  C   . TYR C 1 17  ? 16.78291  17.74586  23.46932  1.000 23.56330  ? 53  TYR E C   1 
ATOM   2402 O  O   . TYR C 1 17  ? 16.86557  17.82081  24.69914  1.000 23.61973  ? 53  TYR E O   1 
ATOM   2403 C  CB  . TYR C 1 17  ? 15.05226  19.03027  22.20490  1.000 26.37932  ? 53  TYR E CB  1 
ATOM   2404 C  CG  . TYR C 1 17  ? 14.62463  20.38949  21.73206  1.000 29.05856  ? 53  TYR E CG  1 
ATOM   2405 C  CD1 . TYR C 1 17  ? 14.24887  21.37060  22.64230  1.000 24.69817  ? 53  TYR E CD1 1 
ATOM   2406 C  CD2 . TYR C 1 17  ? 14.66013  20.71667  20.38133  1.000 31.83510  ? 53  TYR E CD2 1 
ATOM   2407 C  CE1 . TYR C 1 17  ? 13.86814  22.62932  22.22008  1.000 32.79923  ? 53  TYR E CE1 1 
ATOM   2408 C  CE2 . TYR C 1 17  ? 14.28445  21.97297  19.94780  1.000 39.04817  ? 53  TYR E CE2 1 
ATOM   2409 C  CZ  . TYR C 1 17  ? 13.88666  22.92571  20.87131  1.000 35.64463  ? 53  TYR E CZ  1 
ATOM   2410 O  OH  . TYR C 1 17  ? 13.51481  24.17955  20.44076  1.000 37.20948  ? 53  TYR E OH  1 
ATOM   2411 N  N   . PHE C 1 18  ? 16.89676  16.58186  22.81553  1.000 21.48737  ? 54  PHE E N   1 
ATOM   2412 C  CA  . PHE C 1 18  ? 17.21619  15.36752  23.56679  1.000 23.48252  ? 54  PHE E CA  1 
ATOM   2413 C  C   . PHE C 1 18  ? 18.53518  15.53290  24.31117  1.000 22.42215  ? 54  PHE E C   1 
ATOM   2414 O  O   . PHE C 1 18  ? 18.66924  15.10970  25.47051  1.000 22.51827  ? 54  PHE E O   1 
ATOM   2415 C  CB  . PHE C 1 18  ? 17.29420  14.14634  22.64179  1.000 20.23760  ? 54  PHE E CB  1 
ATOM   2416 C  CG  . PHE C 1 18  ? 15.98231  13.75131  22.00315  1.000 24.83698  ? 54  PHE E CG  1 
ATOM   2417 C  CD1 . PHE C 1 18  ? 14.76982  13.89989  22.67328  1.000 19.35241  ? 54  PHE E CD1 1 
ATOM   2418 C  CD2 . PHE C 1 18  ? 15.97209  13.19978  20.71997  1.000 19.85850  ? 54  PHE E CD2 1 
ATOM   2419 C  CE1 . PHE C 1 18  ? 13.56483  13.53497  22.06212  1.000 22.08127  ? 54  PHE E CE1 1 
ATOM   2420 C  CE2 . PHE C 1 18  ? 14.78485  12.81997  20.10505  1.000 19.30376  ? 54  PHE E CE2 1 
ATOM   2421 C  CZ  . PHE C 1 18  ? 13.57084  12.98791  20.77235  1.000 21.80646  ? 54  PHE E CZ  1 
ATOM   2422 N  N   . GLN C 1 19  ? 19.51647  16.17079  23.66724  1.000 25.88248  ? 55  GLN E N   1 
ATOM   2423 C  CA  . GLN C 1 19  ? 20.81220  16.36103  24.31291  1.000 31.60723  ? 55  GLN E CA  1 
ATOM   2424 C  C   . GLN C 1 19  ? 20.69451  17.21083  25.57287  1.000 35.32349  ? 55  GLN E C   1 
ATOM   2425 O  O   . GLN C 1 19  ? 21.50576  17.06207  26.49432  1.000 32.40819  ? 55  GLN E O   1 
ATOM   2426 C  CB  . GLN C 1 19  ? 21.80120  16.99851  23.33606  1.000 43.42200  ? 55  GLN E CB  1 
ATOM   2427 C  CG  . GLN C 1 19  ? 22.48559  16.01524  22.40724  1.000 42.66732  ? 55  GLN E CG  1 
ATOM   2428 C  CD  . GLN C 1 19  ? 23.29690  14.95398  23.13900  1.000 45.37847  ? 55  GLN E CD  1 
ATOM   2429 O  OE1 . GLN C 1 19  ? 24.04095  15.24469  24.08242  1.000 51.52423  ? 55  GLN E OE1 1 
ATOM   2430 N  NE2 . GLN C 1 19  ? 23.15425  13.70997  22.69965  1.000 45.10717  ? 55  GLN E NE2 1 
ATOM   2431 N  N   . GLN C 1 20  ? 19.69217  18.09135  25.64125  1.000 27.31965  ? 56  GLN E N   1 
ATOM   2432 C  CA  . GLN C 1 20  ? 19.43148  18.87623  26.84347  1.000 31.60607  ? 56  GLN E CA  1 
ATOM   2433 C  C   . GLN C 1 20  ? 18.42312  18.22192  27.78518  1.000 24.08717  ? 56  GLN E C   1 
ATOM   2434 O  O   . GLN C 1 20  ? 18.08244  18.81293  28.81818  1.000 30.55896  ? 56  GLN E O   1 
ATOM   2435 C  CB  . GLN C 1 20  ? 18.94913  20.28450  26.45988  1.000 36.46804  ? 56  GLN E CB  1 
ATOM   2436 C  CG  . GLN C 1 20  ? 20.07157  21.23156  26.01518  1.000 38.14145  ? 56  GLN E CG  1 
ATOM   2437 C  CD  . GLN C 1 20  ? 21.41867  20.87509  26.63771  1.000 57.64151  ? 56  GLN E CD  1 
ATOM   2438 O  OE1 . GLN C 1 20  ? 21.58631  20.92792  27.86190  1.000 63.14012  ? 56  GLN E OE1 1 
ATOM   2439 N  NE2 . GLN C 1 20  ? 22.38649  20.51477  25.79544  1.000 59.61069  ? 56  GLN E NE2 1 
ATOM   2440 N  N   . GLY C 1 21  ? 17.93658  17.02852  27.45969  1.000 20.47506  ? 57  GLY E N   1 
ATOM   2441 C  CA  . GLY C 1 21  ? 17.09126  16.27023  28.36473  1.000 18.63834  ? 57  GLY E CA  1 
ATOM   2442 C  C   . GLY C 1 21  ? 15.60728  16.44079  28.15181  1.000 17.36736  ? 57  GLY E C   1 
ATOM   2443 O  O   . GLY C 1 21  ? 14.82643  15.96513  28.98483  1.000 19.54948  ? 57  GLY E O   1 
ATOM   2444 N  N   . TRP C 1 22  ? 15.19625  17.12157  27.07891  1.000 18.93428  ? 58  TRP E N   1 
ATOM   2445 C  CA  . TRP C 1 22  ? 13.78874  17.15814  26.70205  1.000 17.29338  ? 58  TRP E CA  1 
ATOM   2446 C  C   . TRP C 1 22  ? 13.38184  15.80118  26.13602  1.000 17.25343  ? 58  TRP E C   1 
ATOM   2447 O  O   . TRP C 1 22  ? 14.22277  15.02481  25.66859  1.000 16.34534  ? 58  TRP E O   1 
ATOM   2448 C  CB  . TRP C 1 22  ? 13.53636  18.22450  25.63842  1.000 16.64281  ? 58  TRP E CB  1 
ATOM   2449 C  CG  . TRP C 1 22  ? 13.78054  19.63467  26.05077  1.000 20.07687  ? 58  TRP E CG  1 
ATOM   2450 C  CD1 . TRP C 1 22  ? 14.98921  20.21365  26.28014  1.000 22.70238  ? 58  TRP E CD1 1 
ATOM   2451 C  CD2 . TRP C 1 22  ? 12.79965  20.67515  26.19602  1.000 17.07073  ? 58  TRP E CD2 1 
ATOM   2452 N  NE1 . TRP C 1 22  ? 14.82525  21.54138  26.59836  1.000 22.22097  ? 58  TRP E NE1 1 
ATOM   2453 C  CE2 . TRP C 1 22  ? 13.49121  21.85109  26.54342  1.000 22.11684  ? 58  TRP E CE2 1 
ATOM   2454 C  CE3 . TRP C 1 22  ? 11.40227  20.72183  26.07326  1.000 16.71234  ? 58  TRP E CE3 1 
ATOM   2455 C  CZ2 . TRP C 1 22  ? 12.83549  23.07000  26.78749  1.000 22.92517  ? 58  TRP E CZ2 1 
ATOM   2456 C  CZ3 . TRP C 1 22  ? 10.75010  21.93647  26.31113  1.000 17.22654  ? 58  TRP E CZ3 1 
ATOM   2457 C  CH2 . TRP C 1 22  ? 11.46857  23.09007  26.66666  1.000 17.50877  ? 58  TRP E CH2 1 
ATOM   2458 N  N   . PHE C 1 23  ? 12.08154  15.51155  26.18173  1.000 15.04865  ? 59  PHE E N   1 
ATOM   2459 C  CA  . PHE C 1 23  ? 11.57494  14.26051  25.61186  1.000 15.64004  ? 59  PHE E CA  1 
ATOM   2460 C  C   . PHE C 1 23  ? 10.22129  14.51269  24.96038  1.000 18.60676  ? 59  PHE E C   1 
ATOM   2461 O  O   . PHE C 1 23  ? 9.55433   15.51418  25.22809  1.000 16.94591  ? 59  PHE E O   1 
ATOM   2462 C  CB  . PHE C 1 23  ? 11.50503  13.11629  26.65480  1.000 14.31888  ? 59  PHE E CB  1 
ATOM   2463 C  CG  . PHE C 1 23  ? 10.85840  13.51500  27.96005  1.000 16.38318  ? 59  PHE E CG  1 
ATOM   2464 C  CD1 . PHE C 1 23  ? 11.60730  14.11348  28.94967  1.000 18.99946  ? 59  PHE E CD1 1 
ATOM   2465 C  CD2 . PHE C 1 23  ? 9.50210   13.29987  28.17093  1.000 16.57137  ? 59  PHE E CD2 1 
ATOM   2466 C  CE1 . PHE C 1 23  ? 11.01105  14.50658  30.14010  1.000 19.83307  ? 59  PHE E CE1 1 
ATOM   2467 C  CE2 . PHE C 1 23  ? 8.89927   13.67532  29.35916  1.000 19.02634  ? 59  PHE E CE2 1 
ATOM   2468 C  CZ  . PHE C 1 23  ? 9.65232   14.27764  30.34270  1.000 18.51396  ? 59  PHE E CZ  1 
ATOM   2469 N  N   . HIS C 1 24  ? 9.82632   13.58066  24.09075  1.000 13.82498  ? 60  HIS E N   1 
ATOM   2470 C  CA  . HIS C 1 24  ? 8.74411   13.78382  23.13360  1.000 15.84413  ? 60  HIS E CA  1 
ATOM   2471 C  C   . HIS C 1 24  ? 7.54890   12.91047  23.47801  1.000 13.78610  ? 60  HIS E C   1 
ATOM   2472 O  O   . HIS C 1 24  ? 7.68971   11.69078  23.63517  1.000 17.06601  ? 60  HIS E O   1 
ATOM   2473 C  CB  . HIS C 1 24  ? 9.24299   13.47453  21.71337  1.000 17.07140  ? 60  HIS E CB  1 
ATOM   2474 C  CG  . HIS C 1 24  ? 8.15973   13.41096  20.68327  1.000 19.28110  ? 60  HIS E CG  1 
ATOM   2475 N  ND1 . HIS C 1 24  ? 8.20514   12.54318  19.60735  1.000 19.15512  ? 60  HIS E ND1 1 
ATOM   2476 C  CD2 . HIS C 1 24  ? 7.02400   14.13252  20.53727  1.000 20.99105  ? 60  HIS E CD2 1 
ATOM   2477 C  CE1 . HIS C 1 24  ? 7.11512   12.69526  18.87710  1.000 19.60572  ? 60  HIS E CE1 1 
ATOM   2478 N  NE2 . HIS C 1 24  ? 6.38501   13.65694  19.41460  1.000 20.92194  ? 60  HIS E NE2 1 
ATOM   2479 N  N   . PHE C 1 25  ? 6.36972   13.53581  23.57418  1.000 14.31382  ? 61  PHE E N   1 
ATOM   2480 C  CA  . PHE C 1 25  ? 5.10941   12.81392  23.73985  1.000 15.38141  ? 61  PHE E CA  1 
ATOM   2481 C  C   . PHE C 1 25  ? 4.05114   13.53323  22.91369  1.000 17.26077  ? 61  PHE E C   1 
ATOM   2482 O  O   . PHE C 1 25  ? 3.83534   14.74037  23.08831  1.000 15.98584  ? 61  PHE E O   1 
ATOM   2483 C  CB  . PHE C 1 25  ? 4.69305   12.73927  25.22311  1.000 16.01530  ? 61  PHE E CB  1 
ATOM   2484 C  CG  . PHE C 1 25  ? 3.34742   12.08431  25.46900  1.000 16.38658  ? 61  PHE E CG  1 
ATOM   2485 C  CD1 . PHE C 1 25  ? 3.23382   10.70185  25.51567  1.000 16.18785  ? 61  PHE E CD1 1 
ATOM   2486 C  CD2 . PHE C 1 25  ? 2.21044   12.85499  25.72488  1.000 16.08362  ? 61  PHE E CD2 1 
ATOM   2487 C  CE1 . PHE C 1 25  ? 2.00702   10.09119  25.76732  1.000 17.63067  ? 61  PHE E CE1 1 
ATOM   2488 C  CE2 . PHE C 1 25  ? 0.97917   12.24940  25.97680  1.000 18.31797  ? 61  PHE E CE2 1 
ATOM   2489 C  CZ  . PHE C 1 25  ? 0.87585   10.86870  25.99548  1.000 20.57123  ? 61  PHE E CZ  1 
ATOM   2490 N  N   . GLN C 1 26  ? 3.42003   12.79554  22.00163  1.000 17.90590  ? 62  GLN E N   1 
ATOM   2491 C  CA  . GLN C 1 26  ? 2.27283   13.27611  21.22979  1.000 17.15815  ? 62  GLN E CA  1 
ATOM   2492 C  C   . GLN C 1 26  ? 2.49483   14.69358  20.69009  1.000 19.66458  ? 62  GLN E C   1 
ATOM   2493 O  O   . GLN C 1 26  ? 1.72247   15.61647  20.94090  1.000 23.91338  ? 62  GLN E O   1 
ATOM   2494 C  CB  . GLN C 1 26  ? 0.99296   13.18436  22.07593  1.000 17.70631  ? 62  GLN E CB  1 
ATOM   2495 C  CG  . GLN C 1 26  ? 0.53563   11.74381  22.26468  1.000 22.10843  ? 62  GLN E CG  1 
ATOM   2496 C  CD  . GLN C 1 26  ? -0.87006  11.61062  22.82639  1.000 26.27463  ? 62  GLN E CD  1 
ATOM   2497 O  OE1 . GLN C 1 26  ? -1.40098  12.54502  23.43928  1.000 27.75540  ? 62  GLN E OE1 1 
ATOM   2498 N  NE2 . GLN C 1 26  ? -1.48213  10.43767  22.62348  1.000 26.09874  ? 62  GLN E NE2 1 
ATOM   2499 N  N   . LYS C 1 27  ? 3.57417   14.86061  19.93443  1.000 24.43882  ? 63  LYS E N   1 
ATOM   2500 C  CA  . LYS C 1 27  ? 3.80821   16.06168  19.12575  1.000 25.72244  ? 63  LYS E CA  1 
ATOM   2501 C  C   . LYS C 1 27  ? 4.29534   17.24593  19.95785  1.000 25.87911  ? 63  LYS E C   1 
ATOM   2502 O  O   . LYS C 1 27  ? 4.46275   18.33106  19.40372  1.000 21.16096  ? 63  LYS E O   1 
ATOM   2503 C  CB  . LYS C 1 27  ? 2.55432   16.48942  18.33995  1.000 30.92897  ? 63  LYS E CB  1 
ATOM   2504 C  CG  . LYS C 1 27  ? 2.31784   15.67997  17.07112  1.000 45.91750  ? 63  LYS E CG  1 
ATOM   2505 C  CD  . LYS C 1 27  ? 1.04834   16.09653  16.33835  1.000 55.33275  ? 63  LYS E CD  1 
ATOM   2506 C  CE  . LYS C 1 27  ? 0.47132   14.93430  15.51584  1.000 55.97539  ? 63  LYS E CE  1 
ATOM   2507 N  NZ  . LYS C 1 27  ? -0.00285  13.77659  16.33476  1.000 54.86088  ? 63  LYS E NZ  1 
ATOM   2508 N  N   . SER C 1 28  ? 4.54346   17.07272  21.25694  1.000 16.39462  ? 64  SER E N   1 
ATOM   2509 C  CA  . SER C 1 28  ? 5.18940   18.09315  22.06996  1.000 17.72628  ? 64  SER E CA  1 
ATOM   2510 C  C   . SER C 1 28  ? 6.50056   17.58335  22.65276  1.000 16.82432  ? 64  SER E C   1 
ATOM   2511 O  O   . SER C 1 28  ? 6.65773   16.38835  22.92351  1.000 18.55850  ? 64  SER E O   1 
ATOM   2512 C  CB  . SER C 1 28  ? 4.29187   18.51735  23.23426  1.000 16.34370  ? 64  SER E CB  1 
ATOM   2513 O  OG  . SER C 1 28  ? 3.17674   19.26474  22.80032  1.000 18.39669  ? 64  SER E OG  1 
ATOM   2514 N  N   . LEU C 1 29  ? 7.41065   18.52304  22.91441  1.000 15.79093  ? 65  LEU E N   1 
ATOM   2515 C  CA  . LEU C 1 29  ? 8.61652   18.26299  23.68922  1.000 18.31543  ? 65  LEU E CA  1 
ATOM   2516 C  C   . LEU C 1 29  ? 8.39671   18.76616  25.10729  1.000 18.74880  ? 65  LEU E C   1 
ATOM   2517 O  O   . LEU C 1 29  ? 7.81809   19.83932  25.30948  1.000 19.71602  ? 65  LEU E O   1 
ATOM   2518 C  CB  . LEU C 1 29  ? 9.83402   18.97127  23.09525  1.000 19.41013  ? 65  LEU E CB  1 
ATOM   2519 C  CG  . LEU C 1 29  ? 10.41440  18.32525  21.84173  1.000 20.75144  ? 65  LEU E CG  1 
ATOM   2520 C  CD1 . LEU C 1 29  ? 11.35634  19.32684  21.16925  1.000 24.72459  ? 65  LEU E CD1 1 
ATOM   2521 C  CD2 . LEU C 1 29  ? 11.15113  17.03306  22.18328  1.000 24.99040  ? 65  LEU E CD2 1 
ATOM   2522 N  N   . TYR C 1 30  ? 8.85526   17.98976  26.08651  1.000 16.13460  ? 66  TYR E N   1 
ATOM   2523 C  CA  . TYR C 1 30  ? 8.65133   18.32314  27.48794  1.000 15.02657  ? 66  TYR E CA  1 
ATOM   2524 C  C   . TYR C 1 30  ? 9.98784   18.37841  28.20848  1.000 16.07095  ? 66  TYR E C   1 
ATOM   2525 O  O   . TYR C 1 30  ? 10.91361  17.62599  27.88808  1.000 15.85286  ? 66  TYR E O   1 
ATOM   2526 C  CB  . TYR C 1 30  ? 7.77114   17.29118  28.18788  1.000 15.94765  ? 66  TYR E CB  1 
ATOM   2527 C  CG  . TYR C 1 30  ? 6.36908   17.21084  27.64138  1.000 17.02439  ? 66  TYR E CG  1 
ATOM   2528 C  CD1 . TYR C 1 30  ? 6.09119   16.42280  26.52304  1.000 16.29423  ? 66  TYR E CD1 1 
ATOM   2529 C  CD2 . TYR C 1 30  ? 5.31742   17.89693  28.25405  1.000 15.13051  ? 66  TYR E CD2 1 
ATOM   2530 C  CE1 . TYR C 1 30  ? 4.80625   16.33817  26.01462  1.000 14.99937  ? 66  TYR E CE1 1 
ATOM   2531 C  CE2 . TYR C 1 30  ? 4.01816   17.81568  27.75171  1.000 15.24366  ? 66  TYR E CE2 1 
ATOM   2532 C  CZ  . TYR C 1 30  ? 3.77348   17.03245  26.62184  1.000 17.19909  ? 66  TYR E CZ  1 
ATOM   2533 O  OH  . TYR C 1 30  ? 2.49535   16.91980  26.09840  1.000 16.77039  ? 66  TYR E OH  1 
ATOM   2534 N  N   . TYR C 1 31  ? 10.05110  19.23308  29.22840  1.000 15.69810  ? 67  TYR E N   1 
ATOM   2535 C  CA  . TYR C 1 31  ? 11.24131  19.40449  30.03145  1.000 16.67328  ? 67  TYR E CA  1 
ATOM   2536 C  C   . TYR C 1 31  ? 10.83823  19.38065  31.49012  1.000 17.82021  ? 67  TYR E C   1 
ATOM   2537 O  O   . TYR C 1 31  ? 9.90825   20.08859  31.89570  1.000 18.68025  ? 67  TYR E O   1 
ATOM   2538 C  CB  . TYR C 1 31  ? 11.95260  20.70261  29.63391  1.000 16.96142  ? 67  TYR E CB  1 
ATOM   2539 C  CG  . TYR C 1 31  ? 13.07200  21.15754  30.54234  1.000 21.63318  ? 67  TYR E CG  1 
ATOM   2540 C  CD1 . TYR C 1 31  ? 12.78624  21.85994  31.69818  1.000 21.69794  ? 67  TYR E CD1 1 
ATOM   2541 C  CD2 . TYR C 1 31  ? 14.39701  20.85177  30.26606  1.000 30.07376  ? 67  TYR E CD2 1 
ATOM   2542 C  CE1 . TYR C 1 31  ? 13.77493  22.29718  32.52161  1.000 35.40205  ? 67  TYR E CE1 1 
ATOM   2543 C  CE2 . TYR C 1 31  ? 15.41926  21.28444  31.12085  1.000 23.53470  ? 67  TYR E CE2 1 
ATOM   2544 C  CZ  . TYR C 1 31  ? 15.08637  22.00082  32.24064  1.000 26.49738  ? 67  TYR E CZ  1 
ATOM   2545 O  OH  . TYR C 1 31  ? 16.05538  22.45710  33.11515  1.000 42.52031  ? 67  TYR E OH  1 
ATOM   2546 N  N   . ILE C 1 32  ? 11.50097  18.53865  32.26630  1.000 14.38772  ? 68  ILE E N   1 
ATOM   2547 C  CA  . ILE C 1 32  ? 11.29505  18.52127  33.71023  1.000 15.12436  ? 68  ILE E CA  1 
ATOM   2548 C  C   . ILE C 1 32  ? 12.49154  19.20213  34.35398  1.000 17.79165  ? 68  ILE E C   1 
ATOM   2549 O  O   . ILE C 1 32  ? 13.64063  18.85041  34.05890  1.000 16.62369  ? 68  ILE E O   1 
ATOM   2550 C  CB  . ILE C 1 32  ? 11.11360  17.08478  34.22624  1.000 14.16776  ? 68  ILE E CB  1 
ATOM   2551 C  CG1 . ILE C 1 32  ? 9.75586   16.54621  33.76790  1.000 19.02519  ? 68  ILE E CG1 1 
ATOM   2552 C  CG2 . ILE C 1 32  ? 11.22549  17.02789  35.78128  1.000 15.37864  ? 68  ILE E CG2 1 
ATOM   2553 C  CD1 . ILE C 1 32  ? 9.56639   15.05050  34.05164  1.000 20.84918  ? 68  ILE E CD1 1 
ATOM   2554 N  N   . SER C 1 33  ? 12.22840  20.19721  35.21291  1.000 15.38022  ? 69  SER E N   1 
ATOM   2555 C  CA  . SER C 1 33  ? 13.32244  20.96514  35.80451  1.000 14.74821  ? 69  SER E CA  1 
ATOM   2556 C  C   . SER C 1 33  ? 14.11148  20.11482  36.79166  1.000 14.49267  ? 69  SER E C   1 
ATOM   2557 O  O   . SER C 1 33  ? 13.63171  19.09532  37.29311  1.000 15.32927  ? 69  SER E O   1 
ATOM   2558 C  CB  . SER C 1 33  ? 12.79371  22.20002  36.53729  1.000 13.38815  ? 69  SER E CB  1 
ATOM   2559 O  OG  . SER C 1 33  ? 12.09998  21.82987  37.72635  1.000 14.31628  ? 69  SER E OG  1 
ATOM   2560 N  N   . SER C 1 34  ? 15.35487  20.54201  37.05234  1.000 16.44844  ? 70  SER E N   1 
ATOM   2561 C  CA  A SER C 1 34  ? 16.14713  19.90313  38.10007  0.764 18.81079  ? 70  SER E CA  1 
ATOM   2562 C  CA  B SER C 1 34  ? 16.22311  19.94966  38.06126  0.236 19.02521  ? 70  SER E CA  1 
ATOM   2563 C  C   . SER C 1 34  ? 16.30052  20.79994  39.31638  1.000 19.48864  ? 70  SER E C   1 
ATOM   2564 O  O   . SER C 1 34  ? 16.99486  20.42343  40.26654  1.000 21.55695  ? 70  SER E O   1 
ATOM   2565 C  CB  A SER C 1 34  ? 17.52248  19.48589  37.56247  0.764 24.88306  ? 70  SER E CB  1 
ATOM   2566 C  CB  B SER C 1 34  ? 17.63820  19.75483  37.50212  0.236 24.53303  ? 70  SER E CB  1 
ATOM   2567 O  OG  A SER C 1 34  ? 18.24410  20.61591  37.09967  0.764 26.11530  ? 70  SER E OG  1 
ATOM   2568 O  OG  B SER C 1 34  ? 17.62581  19.00188  36.30654  0.236 18.79403  ? 70  SER E OG  1 
ATOM   2569 N  N   . VAL C 1 35  ? 15.63274  21.95303  39.31703  1.000 15.66190  ? 71  VAL E N   1 
ATOM   2570 C  CA  . VAL C 1 35  ? 15.56784  22.85510  40.45497  1.000 16.38170  ? 71  VAL E CA  1 
ATOM   2571 C  C   . VAL C 1 35  ? 14.10483  23.20687  40.67409  1.000 17.41962  ? 71  VAL E C   1 
ATOM   2572 O  O   . VAL C 1 35  ? 13.27853  23.11140  39.76583  1.000 17.40625  ? 71  VAL E O   1 
ATOM   2573 C  CB  . VAL C 1 35  ? 16.39848  24.13663  40.23748  1.000 15.57131  ? 71  VAL E CB  1 
ATOM   2574 C  CG1 . VAL C 1 35  ? 17.88129  23.75196  40.02847  1.000 17.81388  ? 71  VAL E CG1 1 
ATOM   2575 C  CG2 . VAL C 1 35  ? 15.85526  24.97936  39.06838  1.000 18.93796  ? 71  VAL E CG2 1 
ATOM   2576 N  N   . LYS C 1 36  ? 13.79818  23.65164  41.88279  1.000 14.44445  ? 72  LYS E N   1 
ATOM   2577 C  CA  . LYS C 1 36  ? 12.46628  24.17189  42.14487  1.000 12.70776  ? 72  LYS E CA  1 
ATOM   2578 C  C   . LYS C 1 36  ? 12.45357  25.67951  41.95565  1.000 15.92623  ? 72  LYS E C   1 
ATOM   2579 O  O   . LYS C 1 36  ? 13.49133  26.35781  42.02866  1.000 15.71581  ? 72  LYS E O   1 
ATOM   2580 C  CB  . LYS C 1 36  ? 12.03213  23.83573  43.56954  1.000 13.40909  ? 72  LYS E CB  1 
ATOM   2581 C  CG  . LYS C 1 36  ? 12.03797  22.33002  43.84596  1.000 14.33696  ? 72  LYS E CG  1 
ATOM   2582 C  CD  . LYS C 1 36  ? 11.33968  22.03603  45.18063  1.000 17.30848  ? 72  LYS E CD  1 
ATOM   2583 C  CE  . LYS C 1 36  ? 11.17961  20.51912  45.38423  1.000 22.47169  ? 72  LYS E CE  1 
ATOM   2584 N  NZ  . LYS C 1 36  ? 10.42472  20.17679  46.63280  1.000 20.07230  ? 72  LYS E NZ  1 
ATOM   2585 N  N   . ASN C 1 37  ? 11.25695  26.21567  41.75535  1.000 13.54914  ? 73  ASN E N   1 
ATOM   2586 C  CA  . ASN C 1 37  ? 11.16707  27.66204  41.65330  1.000 13.15470  ? 73  ASN E CA  1 
ATOM   2587 C  C   . ASN C 1 37  ? 9.72212   28.09306  41.85121  1.000 14.48110  ? 73  ASN E C   1 
ATOM   2588 O  O   . ASN C 1 37  ? 8.81285   27.26414  41.95749  1.000 14.16731  ? 73  ASN E O   1 
ATOM   2589 C  CB  . ASN C 1 37  ? 11.72104  28.14828  40.31685  1.000 13.84271  ? 73  ASN E CB  1 
ATOM   2590 C  CG  . ASN C 1 37  ? 12.55013  29.40718  40.48568  1.000 12.37003  ? 73  ASN E CG  1 
ATOM   2591 O  OD1 . ASN C 1 37  ? 12.29269  30.19115  41.40853  1.000 16.50299  ? 73  ASN E OD1 1 
ATOM   2592 N  ND2 . ASN C 1 37  ? 13.57179  29.56941  39.66351  1.000 13.52098  ? 73  ASN E ND2 1 
ATOM   2593 N  N   . THR C 1 38  ? 9.53609   29.40926  41.96654  1.000 15.89649  ? 74  THR E N   1 
ATOM   2594 C  CA  . THR C 1 38  ? 8.18955   29.95591  42.04220  1.000 12.86195  ? 74  THR E CA  1 
ATOM   2595 C  C   . THR C 1 38  ? 7.48034   29.73479  40.71115  1.000 12.37468  ? 74  THR E C   1 
ATOM   2596 O  O   . THR C 1 38  ? 8.10358   29.43047  39.69238  1.000 14.20669  ? 74  THR E O   1 
ATOM   2597 C  CB  . THR C 1 38  ? 8.21349   31.45200  42.34532  1.000 15.13765  ? 74  THR E CB  1 
ATOM   2598 O  OG1 . THR C 1 38  ? 8.75236   32.14518  41.20790  1.000 14.26700  ? 74  THR E OG1 1 
ATOM   2599 C  CG2 . THR C 1 38  ? 9.06400   31.75245  43.59636  1.000 16.24349  ? 74  THR E CG2 1 
ATOM   2600 N  N   . TRP C 1 39  ? 6.14987   29.86556  40.72377  1.000 14.01733  ? 75  TRP E N   1 
ATOM   2601 C  CA  . TRP C 1 39  ? 5.42636   29.64079  39.47206  1.000 13.51987  ? 75  TRP E CA  1 
ATOM   2602 C  C   . TRP C 1 39  ? 5.93982   30.57702  38.38264  1.000 13.27669  ? 75  TRP E C   1 
ATOM   2603 O  O   . TRP C 1 39  ? 6.21763   30.14025  37.25588  1.000 13.93719  ? 75  TRP E O   1 
ATOM   2604 C  CB  . TRP C 1 39  ? 3.91555   29.81510  39.68078  1.000 16.50852  ? 75  TRP E CB  1 
ATOM   2605 C  CG  . TRP C 1 39  ? 3.07944   29.37895  38.47658  1.000 14.03298  ? 75  TRP E CG  1 
ATOM   2606 C  CD1 . TRP C 1 39  ? 2.53491   28.13865  38.25759  1.000 14.43171  ? 75  TRP E CD1 1 
ATOM   2607 C  CD2 . TRP C 1 39  ? 2.67859   30.20218  37.36388  1.000 13.58358  ? 75  TRP E CD2 1 
ATOM   2608 N  NE1 . TRP C 1 39  ? 1.82386   28.14839  37.06066  1.000 14.12754  ? 75  TRP E NE1 1 
ATOM   2609 C  CE2 . TRP C 1 39  ? 1.89612   29.40003  36.50636  1.000 13.37170  ? 75  TRP E CE2 1 
ATOM   2610 C  CE3 . TRP C 1 39  ? 2.89737   31.55151  37.01617  1.000 15.28079  ? 75  TRP E CE3 1 
ATOM   2611 C  CZ2 . TRP C 1 39  ? 1.34205   29.89109  35.31066  1.000 15.77991  ? 75  TRP E CZ2 1 
ATOM   2612 C  CZ3 . TRP C 1 39  ? 2.35571   32.03892  35.81626  1.000 20.90315  ? 75  TRP E CZ3 1 
ATOM   2613 C  CH2 . TRP C 1 39  ? 1.58696   31.20697  34.97761  1.000 16.54945  ? 75  TRP E CH2 1 
ATOM   2614 N  N   . HIS C 1 40  ? 6.12146   31.86227  38.71813  1.000 13.66154  ? 76  HIS E N   1 
ATOM   2615 C  CA  . HIS C 1 40  ? 6.48459   32.85022  37.69483  1.000 15.77345  ? 76  HIS E CA  1 
ATOM   2616 C  C   . HIS C 1 40  ? 7.90983   32.65598  37.19249  1.000 14.90880  ? 76  HIS E C   1 
ATOM   2617 O  O   . HIS C 1 40  ? 8.17786   32.82203  35.99734  1.000 15.80996  ? 76  HIS E O   1 
ATOM   2618 C  CB  . HIS C 1 40  ? 6.28834   34.26171  38.25496  1.000 15.52270  ? 76  HIS E CB  1 
ATOM   2619 C  CG  . HIS C 1 40  ? 4.83975   34.61499  38.40909  1.000 19.33166  ? 76  HIS E CG  1 
ATOM   2620 N  ND1 . HIS C 1 40  ? 4.13105   34.34797  39.56064  1.000 25.89885  ? 76  HIS E ND1 1 
ATOM   2621 C  CD2 . HIS C 1 40  ? 3.94498   35.11709  37.52423  1.000 29.16392  ? 76  HIS E CD2 1 
ATOM   2622 C  CE1 . HIS C 1 40  ? 2.87129   34.71018  39.39429  1.000 26.03667  ? 76  HIS E CE1 1 
ATOM   2623 N  NE2 . HIS C 1 40  ? 2.73079   35.17549  38.16608  1.000 28.49990  ? 76  HIS E NE2 1 
ATOM   2624 N  N   . LEU C 1 41  ? 8.83993   32.33903  38.09098  1.000 15.85809  ? 77  LEU E N   1 
ATOM   2625 C  CA  . LEU C 1 41  ? 10.21035  32.08881  37.66096  1.000 12.82610  ? 77  LEU E CA  1 
ATOM   2626 C  C   . LEU C 1 41  ? 10.32598  30.75764  36.92627  1.000 15.73339  ? 77  LEU E C   1 
ATOM   2627 O  O   . LEU C 1 41  ? 11.18321  30.61275  36.04672  1.000 14.83939  ? 77  LEU E O   1 
ATOM   2628 C  CB  . LEU C 1 41  ? 11.13400  32.10448  38.87668  1.000 16.18409  ? 77  LEU E CB  1 
ATOM   2629 C  CG  . LEU C 1 41  ? 11.35879  33.52594  39.40428  1.000 17.91118  ? 77  LEU E CG  1 
ATOM   2630 C  CD1 . LEU C 1 41  ? 12.20355  33.48967  40.67615  1.000 20.49182  ? 77  LEU E CD1 1 
ATOM   2631 C  CD2 . LEU C 1 41  ? 12.04788  34.39082  38.36883  1.000 24.06297  ? 77  LEU E CD2 1 
ATOM   2632 N  N   . SER C 1 42  ? 9.51658   29.76319  37.30622  1.000 14.78583  ? 78  SER E N   1 
ATOM   2633 C  CA  . SER C 1 42  ? 9.44236   28.54984  36.50147  1.000 14.42288  ? 78  SER E CA  1 
ATOM   2634 C  C   . SER C 1 42  ? 9.00838   28.89553  35.09675  1.000 15.51284  ? 78  SER E C   1 
ATOM   2635 O  O   . SER C 1 42  ? 9.62968   28.46594  34.12082  1.000 14.42170  ? 78  SER E O   1 
ATOM   2636 C  CB  . SER C 1 42  ? 8.45691   27.55449  37.09842  1.000 14.94567  ? 78  SER E CB  1 
ATOM   2637 O  OG  . SER C 1 42  ? 8.89183   27.17363  38.38819  1.000 14.57488  ? 78  SER E OG  1 
ATOM   2638 N  N   . ARG C 1 43  ? 7.94646   29.68878  34.98538  1.000 13.17294  ? 79  ARG E N   1 
ATOM   2639 C  CA  . ARG C 1 43  ? 7.45350   30.04721  33.66170  1.000 12.79180  ? 79  ARG E CA  1 
ATOM   2640 C  C   . ARG C 1 43  ? 8.51705   30.80643  32.88707  1.000 16.17496  ? 79  ARG E C   1 
ATOM   2641 O  O   . ARG C 1 43  ? 8.66033   30.61233  31.67878  1.000 15.64426  ? 79  ARG E O   1 
ATOM   2642 C  CB  . ARG C 1 43  ? 6.17860   30.89103  33.74988  1.000 14.23745  ? 79  ARG E CB  1 
ATOM   2643 C  CG  . ARG C 1 43  ? 5.56011   31.06102  32.35885  1.000 17.88627  ? 79  ARG E CG  1 
ATOM   2644 C  CD  . ARG C 1 43  ? 4.30735   31.93618  32.35412  1.000 18.97596  ? 79  ARG E CD  1 
ATOM   2645 N  NE  . ARG C 1 43  ? 3.74472   31.94554  31.00613  1.000 16.11918  ? 79  ARG E NE  1 
ATOM   2646 C  CZ  . ARG C 1 43  ? 3.18836   33.00799  30.44101  1.000 24.30499  ? 79  ARG E CZ  1 
ATOM   2647 N  NH1 . ARG C 1 43  ? 3.06168   34.15206  31.09949  1.000 27.02553  ? 79  ARG E NH1 1 
ATOM   2648 N  NH2 . ARG C 1 43  ? 2.78163   32.93114  29.17372  1.000 21.56603  ? 79  ARG E NH2 1 
ATOM   2649 N  N   . GLU C 1 44  ? 9.26739   31.67981  33.57056  1.000 16.92944  ? 80  GLU E N   1 
ATOM   2650 C  CA  . GLU C 1 44  ? 10.29421  32.47585  32.89245  1.000 16.97049  ? 80  GLU E CA  1 
ATOM   2651 C  C   . GLU C 1 44  ? 11.34944  31.58767  32.24957  1.000 16.86497  ? 80  GLU E C   1 
ATOM   2652 O  O   . GLU C 1 44  ? 11.81633  31.87978  31.13719  1.000 17.68879  ? 80  GLU E O   1 
ATOM   2653 C  CB  . GLU C 1 44  ? 10.95983  33.43437  33.88482  1.000 19.87720  ? 80  GLU E CB  1 
ATOM   2654 C  CG  . GLU C 1 44  ? 10.18971  34.71879  34.12176  1.000 33.44126  ? 80  GLU E CG  1 
ATOM   2655 C  CD  . GLU C 1 44  ? 11.00202  35.74828  34.91043  1.000 46.55562  ? 80  GLU E CD  1 
ATOM   2656 O  OE1 . GLU C 1 44  ? 12.24481  35.73989  34.81879  1.000 35.50126  ? 80  GLU E OE1 1 
ATOM   2657 O  OE2 . GLU C 1 44  ? 10.39168  36.58045  35.61377  1.000 60.39935  ? 80  GLU E OE2 1 
ATOM   2658 N  N   . TYR C 1 45  ? 11.74862  30.50752  32.94160  1.000 14.52607  ? 81  TYR E N   1 
ATOM   2659 C  CA  . TYR C 1 45  ? 12.67167  29.54027  32.35175  1.000 16.09249  ? 81  TYR E CA  1 
ATOM   2660 C  C   . TYR C 1 45  ? 12.08599  28.96642  31.06736  1.000 17.86366  ? 81  TYR E C   1 
ATOM   2661 O  O   . TYR C 1 45  ? 12.75905  28.91810  30.02897  1.000 16.58240  ? 81  TYR E O   1 
ATOM   2662 C  CB  . TYR C 1 45  ? 13.00293  28.39330  33.32965  1.000 13.95498  ? 81  TYR E CB  1 
ATOM   2663 C  CG  . TYR C 1 45  ? 13.95173  27.39143  32.67922  1.000 15.95440  ? 81  TYR E CG  1 
ATOM   2664 C  CD1 . TYR C 1 45  ? 15.32884  27.54533  32.77739  1.000 18.36682  ? 81  TYR E CD1 1 
ATOM   2665 C  CD2 . TYR C 1 45  ? 13.45789  26.34279  31.89456  1.000 16.28100  ? 81  TYR E CD2 1 
ATOM   2666 C  CE1 . TYR C 1 45  ? 16.19533  26.66215  32.13931  1.000 23.34783  ? 81  TYR E CE1 1 
ATOM   2667 C  CE2 . TYR C 1 45  ? 14.31344  25.46565  31.25541  1.000 17.49804  ? 81  TYR E CE2 1 
ATOM   2668 C  CZ  . TYR C 1 45  ? 15.66908  25.62898  31.37698  1.000 19.99356  ? 81  TYR E CZ  1 
ATOM   2669 O  OH  . TYR C 1 45  ? 16.51006  24.74750  30.74355  1.000 19.99976  ? 81  TYR E OH  1 
ATOM   2670 N  N   . CYS C 1 46  ? 10.82650  28.51393  31.12150  1.000 14.44432  ? 82  CYS E N   1 
ATOM   2671 C  CA  . CYS C 1 46  ? 10.23774  27.89173  29.93868  1.000 13.36367  ? 82  CYS E CA  1 
ATOM   2672 C  C   . CYS C 1 46  ? 10.18152  28.88501  28.78609  1.000 15.62398  ? 82  CYS E C   1 
ATOM   2673 O  O   . CYS C 1 46  ? 10.45109  28.52302  27.63329  1.000 17.97978  ? 82  CYS E O   1 
ATOM   2674 C  CB  . CYS C 1 46  ? 8.82546   27.39118  30.24166  1.000 14.84129  ? 82  CYS E CB  1 
ATOM   2675 S  SG  . CYS C 1 46  ? 8.75088   26.10439  31.54331  1.000 18.56923  ? 82  CYS E SG  1 
ATOM   2676 N  N   . LEU C 1 47  ? 9.83323   30.13784  29.08964  1.000 17.38134  ? 83  LEU E N   1 
ATOM   2677 C  CA  . LEU C 1 47  ? 9.72543   31.16683  28.04679  1.000 15.90051  ? 83  LEU E CA  1 
ATOM   2678 C  C   . LEU C 1 47  ? 11.08354  31.43432  27.42619  1.000 16.82684  ? 83  LEU E C   1 
ATOM   2679 O  O   . LEU C 1 47  ? 11.19878  31.59308  26.20149  1.000 19.59087  ? 83  LEU E O   1 
ATOM   2680 C  CB  . LEU C 1 47  ? 9.15671   32.45524  28.64302  1.000 15.66235  ? 83  LEU E CB  1 
ATOM   2681 C  CG  . LEU C 1 47  ? 7.68328   32.36898  29.08058  1.000 16.23231  ? 83  LEU E CG  1 
ATOM   2682 C  CD1 . LEU C 1 47  ? 7.25499   33.57805  29.93449  1.000 18.82661  ? 83  LEU E CD1 1 
ATOM   2683 C  CD2 . LEU C 1 47  ? 6.74151   32.18886  27.88155  1.000 20.30358  ? 83  LEU E CD2 1 
ATOM   2684 N  N   . GLN C 1 48  ? 12.12305  31.46092  28.26416  1.000 17.91191  ? 84  GLN E N   1 
ATOM   2685 C  CA  . GLN C 1 48  ? 13.47771  31.68379  27.77344  1.000 23.55540  ? 84  GLN E CA  1 
ATOM   2686 C  C   . GLN C 1 48  ? 13.87983  30.60464  26.77991  1.000 25.95461  ? 84  GLN E C   1 
ATOM   2687 O  O   . GLN C 1 48  ? 14.64518  30.87256  25.84500  1.000 23.69962  ? 84  GLN E O   1 
ATOM   2688 C  CB  . GLN C 1 48  ? 14.42461  31.76354  28.98587  1.000 26.84058  ? 84  GLN E CB  1 
ATOM   2689 C  CG  . GLN C 1 48  ? 15.91045  31.43319  28.78208  1.000 42.15942  ? 84  GLN E CG  1 
ATOM   2690 C  CD  . GLN C 1 48  ? 16.53997  30.77251  30.03683  1.000 55.24965  ? 84  GLN E CD  1 
ATOM   2691 O  OE1 . GLN C 1 48  ? 16.51535  31.33988  31.13844  1.000 40.55772  ? 84  GLN E OE1 1 
ATOM   2692 N  NE2 . GLN C 1 48  ? 17.09680  29.56820  29.86512  1.000 50.82043  ? 84  GLN E NE2 1 
ATOM   2693 N  N   . GLU C 1 49  ? 13.33139  29.40005  26.92669  1.000 20.75514  ? 85  GLU E N   1 
ATOM   2694 C  CA  . GLU C 1 49  ? 13.62950  28.28723  26.03864  1.000 20.04865  ? 85  GLU E CA  1 
ATOM   2695 C  C   . GLU C 1 49  ? 12.69573  28.21964  24.84545  1.000 19.17589  ? 85  GLU E C   1 
ATOM   2696 O  O   . GLU C 1 49  ? 12.70509  27.21354  24.13436  1.000 22.86716  ? 85  GLU E O   1 
ATOM   2697 C  CB  . GLU C 1 49  ? 13.56208  26.95527  26.80236  1.000 19.65980  ? 85  GLU E CB  1 
ATOM   2698 C  CG  . GLU C 1 49  ? 14.59784  26.83983  27.90669  1.000 22.38394  ? 85  GLU E CG  1 
ATOM   2699 C  CD  . GLU C 1 49  ? 16.01411  26.95605  27.36683  1.000 31.06445  ? 85  GLU E CD  1 
ATOM   2700 O  OE1 . GLU C 1 49  ? 16.34537  26.20819  26.42642  1.000 34.33362  ? 85  GLU E OE1 1 
ATOM   2701 O  OE2 . GLU C 1 49  ? 16.78387  27.80590  27.86688  1.000 36.03171  ? 85  GLU E OE2 1 
ATOM   2702 N  N   . GLY C 1 50  ? 11.89777  29.25696  24.60885  1.000 22.02464  ? 86  GLY E N   1 
ATOM   2703 C  CA  . GLY C 1 50  ? 10.94740  29.22729  23.51155  1.000 23.35001  ? 86  GLY E CA  1 
ATOM   2704 C  C   . GLY C 1 50  ? 9.75173   28.33882  23.76241  1.000 25.08151  ? 86  GLY E C   1 
ATOM   2705 O  O   . GLY C 1 50  ? 9.09776   27.89903  22.80715  1.000 23.84808  ? 86  GLY E O   1 
ATOM   2706 N  N   . ALA C 1 51  ? 9.42447   28.10104  25.02857  1.000 17.26781  ? 87  ALA E N   1 
ATOM   2707 C  CA  . ALA C 1 51  ? 8.36962   27.17160  25.40638  1.000 14.67099  ? 87  ALA E CA  1 
ATOM   2708 C  C   . ALA C 1 51  ? 7.46974   27.91220  26.39067  1.000 17.51971  ? 87  ALA E C   1 
ATOM   2709 O  O   . ALA C 1 51  ? 7.45819   29.15023  26.44823  1.000 17.31483  ? 87  ALA E O   1 
ATOM   2710 C  CB  . ALA C 1 51  ? 8.97421   25.88998  25.99586  1.000 17.56539  ? 87  ALA E CB  1 
ATOM   2711 N  N   . ASP C 1 52  ? 6.71408   27.15099  27.17582  1.000 15.78736  ? 88  ASP E N   1 
ATOM   2712 C  CA  . ASP C 1 52  ? 5.90527   27.71227  28.25052  1.000 15.88528  ? 88  ASP E CA  1 
ATOM   2713 C  C   . ASP C 1 52  ? 5.67167   26.57961  29.23833  1.000 16.17069  ? 88  ASP E C   1 
ATOM   2714 O  O   . ASP C 1 52  ? 6.08430   25.44106  29.00795  1.000 15.76719  ? 88  ASP E O   1 
ATOM   2715 C  CB  . ASP C 1 52  ? 4.58865   28.30219  27.70611  1.000 15.67031  ? 88  ASP E CB  1 
ATOM   2716 C  CG  . ASP C 1 52  ? 4.08220   29.48463  28.52064  1.000 23.09096  ? 88  ASP E CG  1 
ATOM   2717 O  OD1 . ASP C 1 52  ? 4.34388   29.52353  29.73898  1.000 17.36514  ? 88  ASP E OD1 1 
ATOM   2718 O  OD2 . ASP C 1 52  ? 3.39951   30.37008  27.93407  1.000 21.20587  ? 88  ASP E OD2 1 
ATOM   2719 N  N   . LEU C 1 53  ? 5.04223   26.89775  30.36771  1.000 15.21843  ? 89  LEU E N   1 
ATOM   2720 C  CA  . LEU C 1 53  ? 4.65055   25.81468  31.26251  1.000 14.56605  ? 89  LEU E CA  1 
ATOM   2721 C  C   . LEU C 1 53  ? 3.66719   24.86930  30.56024  1.000 16.64194  ? 89  LEU E C   1 
ATOM   2722 O  O   . LEU C 1 53  ? 2.94675   25.25045  29.62521  1.000 15.25313  ? 89  LEU E O   1 
ATOM   2723 C  CB  . LEU C 1 53  ? 4.03022   26.38608  32.53947  1.000 14.87223  ? 89  LEU E CB  1 
ATOM   2724 C  CG  . LEU C 1 53  ? 5.06034   27.01133  33.48191  1.000 14.78968  ? 89  LEU E CG  1 
ATOM   2725 C  CD1 . LEU C 1 53  ? 4.32753   27.77269  34.60803  1.000 15.46836  ? 89  LEU E CD1 1 
ATOM   2726 C  CD2 . LEU C 1 53  ? 5.97701   25.91858  34.07822  1.000 17.23439  ? 89  LEU E CD2 1 
ATOM   2727 N  N   . ALA C 1 54  ? 3.65809   23.61516  31.00607  1.000 14.79286  ? 90  ALA E N   1 
ATOM   2728 C  CA  . ALA C 1 54  ? 2.86829   22.57299  30.34573  1.000 15.68813  ? 90  ALA E CA  1 
ATOM   2729 C  C   . ALA C 1 54  ? 1.37146   22.87880  30.36664  1.000 16.61524  ? 90  ALA E C   1 
ATOM   2730 O  O   . ALA C 1 54  ? 0.82117   23.33139  31.37402  1.000 14.79734  ? 90  ALA E O   1 
ATOM   2731 C  CB  . ALA C 1 54  ? 3.12876   21.23015  31.03567  1.000 15.26602  ? 90  ALA E CB  1 
ATOM   2732 N  N   . ILE C 1 55  ? 0.70576   22.60144  29.24736  1.000 13.31493  ? 91  ILE E N   1 
ATOM   2733 C  CA  . ILE C 1 55  ? -0.73775  22.79457  29.09810  1.000 14.74655  ? 91  ILE E CA  1 
ATOM   2734 C  C   . ILE C 1 55  ? -1.38185  21.43046  28.89793  1.000 14.81723  ? 91  ILE E C   1 
ATOM   2735 O  O   . ILE C 1 55  ? -1.01152  20.70416  27.97055  1.000 14.89414  ? 91  ILE E O   1 
ATOM   2736 C  CB  . ILE C 1 55  ? -1.04460  23.71176  27.90299  1.000 16.72867  ? 91  ILE E CB  1 
ATOM   2737 C  CG1 . ILE C 1 55  ? -0.48586  25.12084  28.15290  1.000 18.31136  ? 91  ILE E CG1 1 
ATOM   2738 C  CG2 . ILE C 1 55  ? -2.53333  23.75991  27.62490  1.000 16.50164  ? 91  ILE E CG2 1 
ATOM   2739 C  CD1 . ILE C 1 55  ? -0.34256  25.94167  26.85393  1.000 21.34236  ? 91  ILE E CD1 1 
ATOM   2740 N  N   . ILE C 1 56  ? -2.35740  21.08276  29.73528  1.000 15.63394  ? 92  ILE E N   1 
ATOM   2741 C  CA  . ILE C 1 56  ? -2.91462  19.73252  29.70843  1.000 17.27395  ? 92  ILE E CA  1 
ATOM   2742 C  C   . ILE C 1 56  ? -4.17382  19.76593  28.84766  1.000 18.42633  ? 92  ILE E C   1 
ATOM   2743 O  O   . ILE C 1 56  ? -5.19966  20.33137  29.24214  1.000 21.09960  ? 92  ILE E O   1 
ATOM   2744 C  CB  . ILE C 1 56  ? -3.18761  19.18976  31.11532  1.000 20.07584  ? 92  ILE E CB  1 
ATOM   2745 C  CG1 . ILE C 1 56  ? -1.88943  19.22625  31.95071  1.000 16.95616  ? 92  ILE E CG1 1 
ATOM   2746 C  CG2 . ILE C 1 56  ? -3.70965  17.73550  31.00247  1.000 19.62744  ? 92  ILE E CG2 1 
ATOM   2747 C  CD1 . ILE C 1 56  ? -0.70507  18.44681  31.32923  1.000 18.76146  ? 92  ILE E CD1 1 
ATOM   2748 N  N   . ASN C 1 57  ? -4.08481  19.15446  27.66690  1.000 18.36427  ? 93  ASN E N   1 
ATOM   2749 C  CA  . ASN C 1 57  ? -5.11803  19.24214  26.64021  1.000 22.69013  ? 93  ASN E CA  1 
ATOM   2750 C  C   . ASN C 1 57  ? -5.95891  17.98984  26.49562  1.000 25.74659  ? 93  ASN E C   1 
ATOM   2751 O  O   . ASN C 1 57  ? -6.91391  18.00554  25.70777  1.000 23.64989  ? 93  ASN E O   1 
ATOM   2752 C  CB  . ASN C 1 57  ? -4.48834  19.51764  25.27097  1.000 22.43263  ? 93  ASN E CB  1 
ATOM   2753 C  CG  . ASN C 1 57  ? -3.69998  20.77800  25.25443  1.000 23.05270  ? 93  ASN E CG  1 
ATOM   2754 O  OD1 . ASN C 1 57  ? -2.48061  20.74535  25.39137  1.000 20.60538  ? 93  ASN E OD1 1 
ATOM   2755 N  ND2 . ASN C 1 57  ? -4.38272  21.90783  25.09699  1.000 25.86565  ? 93  ASN E ND2 1 
ATOM   2756 N  N   . SER C 1 58  ? -5.61694  16.90280  27.18574  1.000 21.32477  ? 94  SER E N   1 
ATOM   2757 C  CA  . SER C 1 58  ? -6.33568  15.64803  27.00813  1.000 19.33114  ? 94  SER E CA  1 
ATOM   2758 C  C   . SER C 1 58  ? -6.15437  14.78328  28.24591  1.000 23.29111  ? 94  SER E C   1 
ATOM   2759 O  O   . SER C 1 58  ? -5.25082  15.00765  29.05770  1.000 18.54918  ? 94  SER E O   1 
ATOM   2760 C  CB  . SER C 1 58  ? -5.86637  14.90027  25.74060  1.000 19.31791  ? 94  SER E CB  1 
ATOM   2761 O  OG  . SER C 1 58  ? -4.54718  14.36871  25.89175  1.000 20.58761  ? 94  SER E OG  1 
ATOM   2762 N  N   . ARG C 1 59  ? -7.04838  13.80101  28.39459  1.000 20.00375  ? 95  ARG E N   1 
ATOM   2763 C  CA  . ARG C 1 59  ? -6.89142  12.83601  29.48014  1.000 22.34436  ? 95  ARG E CA  1 
ATOM   2764 C  C   . ARG C 1 59  ? -5.57350  12.07961  29.35673  1.000 18.33562  ? 95  ARG E C   1 
ATOM   2765 O  O   . ARG C 1 59  ? -4.89810  11.82461  30.36160  1.000 20.18452  ? 95  ARG E O   1 
ATOM   2766 C  CB  . ARG C 1 59  ? -8.07091  11.85774  29.49735  1.000 25.52689  ? 95  ARG E CB  1 
ATOM   2767 C  CG  . ARG C 1 59  ? -7.89719  10.70282  30.47358  1.000 36.98772  ? 95  ARG E CG  1 
ATOM   2768 C  CD  . ARG C 1 59  ? -9.19062  9.91591   30.65037  1.000 42.08830  ? 95  ARG E CD  1 
ATOM   2769 N  NE  . ARG C 1 59  ? -10.31511 10.77808  30.99344  1.000 60.33413  ? 95  ARG E NE  1 
ATOM   2770 C  CZ  . ARG C 1 59  ? -11.02110 10.67703  32.11188  1.000 69.43755  ? 95  ARG E CZ  1 
ATOM   2771 N  NH1 . ARG C 1 59  ? -10.77558 9.72674   33.00015  1.000 66.41746  ? 95  ARG E NH1 1 
ATOM   2772 N  NH2 . ARG C 1 59  ? -12.00104 11.54750  32.34185  1.000 55.90357  ? 95  ARG E NH2 1 
ATOM   2773 N  N   . ALA C 1 60  ? -5.18217  11.71384  28.13408  1.000 20.67283  ? 96  ALA E N   1 
ATOM   2774 C  CA  . ALA C 1 60  ? -3.91125  11.01650  27.97316  1.000 19.34446  ? 96  ALA E CA  1 
ATOM   2775 C  C   . ALA C 1 60  ? -2.74395  11.88104  28.42045  1.000 19.34260  ? 96  ALA E C   1 
ATOM   2776 O  O   . ALA C 1 60  ? -1.75163  11.36178  28.93398  1.000 19.48915  ? 96  ALA E O   1 
ATOM   2777 C  CB  . ALA C 1 60  ? -3.72075  10.58643  26.51460  1.000 22.36271  ? 96  ALA E CB  1 
ATOM   2778 N  N   . GLU C 1 61  ? -2.83028  13.19571  28.21524  1.000 18.46266  ? 97  GLU E N   1 
ATOM   2779 C  CA  . GLU C 1 61  ? -1.71206  14.03827  28.62229  1.000 17.39910  ? 97  GLU E CA  1 
ATOM   2780 C  C   . GLU C 1 61  ? -1.68814  14.16501  30.13330  1.000 17.08954  ? 97  GLU E C   1 
ATOM   2781 O  O   . GLU C 1 61  ? -0.60931  14.22245  30.74164  1.000 17.01467  ? 97  GLU E O   1 
ATOM   2782 C  CB  . GLU C 1 61  ? -1.79636  15.41667  27.95598  1.000 18.05361  ? 97  GLU E CB  1 
ATOM   2783 C  CG  . GLU C 1 61  ? -0.47317  16.19525  28.02499  1.000 14.59991  ? 97  GLU E CG  1 
ATOM   2784 C  CD  . GLU C 1 61  ? -0.52844  17.50100  27.27283  1.000 15.28448  ? 97  GLU E CD  1 
ATOM   2785 O  OE1 . GLU C 1 61  ? -1.65363  17.91003  26.87564  1.000 18.64095  ? 97  GLU E OE1 1 
ATOM   2786 O  OE2 . GLU C 1 61  ? 0.55917   18.09990  27.07600  1.000 14.63781  ? 97  GLU E OE2 1 
ATOM   2787 N  N   . GLN C 1 62  ? -2.87051  14.17511  30.75583  1.000 17.42432  ? 98  GLN E N   1 
ATOM   2788 C  CA  . GLN C 1 62  ? -2.91752  14.20651  32.20790  1.000 15.36409  ? 98  GLN E CA  1 
ATOM   2789 C  C   . GLN C 1 62  ? -2.34066  12.92111  32.78323  1.000 16.78451  ? 98  GLN E C   1 
ATOM   2790 O  O   . GLN C 1 62  ? -1.58897  12.95768  33.75415  1.000 15.68928  ? 98  GLN E O   1 
ATOM   2791 C  CB  . GLN C 1 62  ? -4.35541  14.40978  32.68987  1.000 13.88375  ? 98  GLN E CB  1 
ATOM   2792 C  CG  . GLN C 1 62  ? -4.49329  14.35693  34.21287  1.000 15.01952  ? 98  GLN E CG  1 
ATOM   2793 C  CD  . GLN C 1 62  ? -3.77978  15.51061  34.93204  1.000 13.89414  ? 98  GLN E CD  1 
ATOM   2794 O  OE1 . GLN C 1 62  ? -3.52595  16.56564  34.35293  1.000 15.60936  ? 98  GLN E OE1 1 
ATOM   2795 N  NE2 . GLN C 1 62  ? -3.48988  15.30900  36.21349  1.000 15.02101  ? 98  GLN E NE2 1 
ATOM   2796 N  N   . ALA C 1 63  ? -2.67435  11.77285  32.18744  1.000 15.72047  ? 99  ALA E N   1 
ATOM   2797 C  CA  . ALA C 1 63  ? -2.11053  10.50522  32.65773  1.000 16.81792  ? 99  ALA E CA  1 
ATOM   2798 C  C   . ALA C 1 63  ? -0.58821  10.47548  32.50302  1.000 13.96224  ? 99  ALA E C   1 
ATOM   2799 O  O   . ALA C 1 63  ? 0.12897   9.96139   33.36959  1.000 16.74229  ? 99  ALA E O   1 
ATOM   2800 C  CB  . ALA C 1 63  ? -2.74356  9.34165   31.89606  1.000 17.42724  ? 99  ALA E CB  1 
ATOM   2801 N  N   . PHE C 1 64  ? -0.08258  11.02486  31.40158  1.000 14.89549  ? 100 PHE E N   1 
ATOM   2802 C  CA  . PHE C 1 64  ? 1.35599   11.12749  31.19628  1.000 15.04704  ? 100 PHE E CA  1 
ATOM   2803 C  C   . PHE C 1 64  ? 1.98421   11.98076  32.30044  1.000 18.86429  ? 100 PHE E C   1 
ATOM   2804 O  O   . PHE C 1 64  ? 2.96959   11.58006  32.94712  1.000 17.17988  ? 100 PHE E O   1 
ATOM   2805 C  CB  . PHE C 1 64  ? 1.54489   11.69351  29.77478  1.000 14.65773  ? 100 PHE E CB  1 
ATOM   2806 C  CG  . PHE C 1 64  ? 2.89676   12.29335  29.46015  1.000 17.24684  ? 100 PHE E CG  1 
ATOM   2807 C  CD1 . PHE C 1 64  ? 3.97545   11.47601  29.13070  1.000 16.94058  ? 100 PHE E CD1 1 
ATOM   2808 C  CD2 . PHE C 1 64  ? 3.03912   13.67667  29.34264  1.000 20.20246  ? 100 PHE E CD2 1 
ATOM   2809 C  CE1 . PHE C 1 64  ? 5.20045   12.02842  28.76726  1.000 17.40809  ? 100 PHE E CE1 1 
ATOM   2810 C  CE2 . PHE C 1 64  ? 4.26170   14.25501  28.98010  1.000 17.47586  ? 100 PHE E CE2 1 
ATOM   2811 C  CZ  . PHE C 1 64  ? 5.35263   13.42373  28.69562  1.000 19.32073  ? 100 PHE E CZ  1 
ATOM   2812 N  N   . LEU C 1 65  ? 1.36626   13.12680  32.58508  1.000 15.09260  ? 101 LEU E N   1 
ATOM   2813 C  CA  . LEU C 1 65  ? 1.84319   14.00159  33.65577  1.000 16.72713  ? 101 LEU E CA  1 
ATOM   2814 C  C   . LEU C 1 65  ? 1.86297   13.26491  34.98896  1.000 14.26021  ? 101 LEU E C   1 
ATOM   2815 O  O   . LEU C 1 65  ? 2.84877   13.32164  35.74190  1.000 17.96436  ? 101 LEU E O   1 
ATOM   2816 C  CB  . LEU C 1 65  ? 0.93390   15.23568  33.75119  1.000 13.82550  ? 101 LEU E CB  1 
ATOM   2817 C  CG  . LEU C 1 65  ? 1.16216   16.14306  34.97175  1.000 16.16959  ? 101 LEU E CG  1 
ATOM   2818 C  CD1 . LEU C 1 65  ? 2.52165   16.81131  34.90027  1.000 16.68701  ? 101 LEU E CD1 1 
ATOM   2819 C  CD2 . LEU C 1 65  ? 0.05114   17.20479  35.01663  1.000 16.14067  ? 101 LEU E CD2 1 
ATOM   2820 N  N   . GLU C 1 66  ? 0.75852   12.58371  35.30445  1.000 15.99681  ? 102 GLU E N   1 
ATOM   2821 C  CA  . GLU C 1 66  ? 0.62644   11.93505  36.60791  1.000 14.34188  ? 102 GLU E CA  1 
ATOM   2822 C  C   . GLU C 1 66  ? 1.63220   10.81955  36.79175  1.000 16.47706  ? 102 GLU E C   1 
ATOM   2823 O  O   . GLU C 1 66  ? 2.09074   10.55875  37.91549  1.000 17.09871  ? 102 GLU E O   1 
ATOM   2824 C  CB  . GLU C 1 66  ? -0.79746  11.38329  36.78268  1.000 18.85944  ? 102 GLU E CB  1 
ATOM   2825 C  CG  . GLU C 1 66  ? -1.71449  12.48049  37.22085  1.000 25.70110  ? 102 GLU E CG  1 
ATOM   2826 C  CD  . GLU C 1 66  ? -3.09302  12.02833  37.63211  1.000 38.93846  ? 102 GLU E CD  1 
ATOM   2827 O  OE1 . GLU C 1 66  ? -3.35196  10.79848  37.64264  1.000 36.58599  ? 102 GLU E OE1 1 
ATOM   2828 O  OE2 . GLU C 1 66  ? -3.86030  12.91509  38.08840  1.000 31.08441  ? 102 GLU E OE2 1 
ATOM   2829 N  N   . ASN C 1 67  ? 1.99529   10.16001  35.70725  1.000 15.65488  ? 103 ASN E N   1 
ATOM   2830 C  CA  . ASN C 1 67  ? 2.82742   8.97505   35.82777  1.000 16.54652  ? 103 ASN E CA  1 
ATOM   2831 C  C   . ASN C 1 67  ? 4.26909   9.31782   36.17881  1.000 17.63805  ? 103 ASN E C   1 
ATOM   2832 O  O   . ASN C 1 67  ? 5.06335   8.40702   36.45514  1.000 18.08337  ? 103 ASN E O   1 
ATOM   2833 C  CB  . ASN C 1 67  ? 2.74635   8.18301   34.52290  1.000 15.32361  ? 103 ASN E CB  1 
ATOM   2834 C  CG  . ASN C 1 67  ? 3.32711   6.77717   34.65928  1.000 19.16537  ? 103 ASN E CG  1 
ATOM   2835 O  OD1 . ASN C 1 67  ? 2.98788   6.04228   35.60321  1.000 19.46093  ? 103 ASN E OD1 1 
ATOM   2836 N  ND2 . ASN C 1 67  ? 4.19504   6.40294   33.73039  1.000 16.28559  ? 103 ASN E ND2 1 
ATOM   2837 N  N   . PHE C 1 68  ? 4.64250   10.60095  36.15270  1.000 15.04092  ? 104 PHE E N   1 
ATOM   2838 C  CA  . PHE C 1 68  ? 5.98098   10.94105  36.59327  1.000 13.59001  ? 104 PHE E CA  1 
ATOM   2839 C  C   . PHE C 1 68  ? 6.07605   10.98455  38.11153  1.000 15.44839  ? 104 PHE E C   1 
ATOM   2840 O  O   . PHE C 1 68  ? 7.17802   11.13584  38.64036  1.000 15.40040  ? 104 PHE E O   1 
ATOM   2841 C  CB  . PHE C 1 68  ? 6.41128   12.26794  35.96356  1.000 16.50642  ? 104 PHE E CB  1 
ATOM   2842 C  CG  . PHE C 1 68  ? 6.64125   12.14301  34.46629  1.000 13.06793  ? 104 PHE E CG  1 
ATOM   2843 C  CD1 . PHE C 1 68  ? 7.59398   11.23641  33.97579  1.000 18.73783  ? 104 PHE E CD1 1 
ATOM   2844 C  CD2 . PHE C 1 68  ? 5.88669   12.87152  33.56986  1.000 16.71088  ? 104 PHE E CD2 1 
ATOM   2845 C  CE1 . PHE C 1 68  ? 7.79647   11.07563  32.61263  1.000 20.41649  ? 104 PHE E CE1 1 
ATOM   2846 C  CE2 . PHE C 1 68  ? 6.09472   12.72612  32.19287  1.000 17.80492  ? 104 PHE E CE2 1 
ATOM   2847 C  CZ  . PHE C 1 68  ? 7.04723   11.83426  31.71673  1.000 20.27448  ? 104 PHE E CZ  1 
ATOM   2848 N  N   . LYS C 1 69  ? 4.94631   10.85999  38.81515  1.000 12.40767  ? 105 LYS E N   1 
ATOM   2849 C  CA  . LYS C 1 69  ? 4.96439   10.69798  40.26675  1.000 14.31330  ? 105 LYS E CA  1 
ATOM   2850 C  C   . LYS C 1 69  ? 5.68654   11.86854  40.93652  1.000 14.51939  ? 105 LYS E C   1 
ATOM   2851 O  O   . LYS C 1 69  ? 6.49472   11.69983  41.84805  1.000 17.84883  ? 105 LYS E O   1 
ATOM   2852 C  CB  . LYS C 1 69  ? 5.59023   9.34408   40.63574  1.000 16.97650  ? 105 LYS E CB  1 
ATOM   2853 C  CG  . LYS C 1 69  ? 4.94199   8.19902   39.84509  1.000 20.44071  ? 105 LYS E CG  1 
ATOM   2854 C  CD  . LYS C 1 69  ? 5.48592   6.81164   40.25458  1.000 23.13519  ? 105 LYS E CD  1 
ATOM   2855 C  CE  . LYS C 1 69  ? 5.72293   5.89979   39.03974  1.000 18.43769  ? 105 LYS E CE  1 
ATOM   2856 N  NZ  . LYS C 1 69  ? 4.58287   5.96080   38.09640  1.000 15.58274  ? 105 LYS E NZ  1 
ATOM   2857 N  N   . MET C 1 70  ? 5.40000   13.07515  40.46018  1.000 13.46117  ? 106 MET E N   1 
ATOM   2858 C  CA  . MET C 1 70  ? 6.22026   14.23412  40.77265  1.000 13.45586  ? 106 MET E CA  1 
ATOM   2859 C  C   . MET C 1 70  ? 5.31147   15.43615  40.95508  1.000 14.96046  ? 106 MET E C   1 
ATOM   2860 O  O   . MET C 1 70  ? 4.44904   15.68410  40.11045  1.000 17.28070  ? 106 MET E O   1 
ATOM   2861 C  CB  . MET C 1 70  ? 7.19216   14.53090  39.61369  1.000 18.96583  ? 106 MET E CB  1 
ATOM   2862 C  CG  . MET C 1 70  ? 8.26964   15.54234  39.94170  1.000 24.66842  ? 106 MET E CG  1 
ATOM   2863 S  SD  . MET C 1 70  ? 9.37271   15.78395  38.51376  1.000 22.77857  ? 106 MET E SD  1 
ATOM   2864 C  CE  . MET C 1 70  ? 10.19775  14.16724  38.34911  1.000 20.86215  ? 106 MET E CE  1 
ATOM   2865 N  N   . THR C 1 71  ? 5.51839   16.20236  42.01583  1.000 16.63382  ? 107 THR E N   1 
ATOM   2866 C  CA  . THR C 1 71  ? 4.76631   17.44417  42.16810  1.000 12.85894  ? 107 THR E CA  1 
ATOM   2867 C  C   . THR C 1 71  ? 5.37737   18.50259  41.25466  1.000 14.19019  ? 107 THR E C   1 
ATOM   2868 O  O   . THR C 1 71  ? 6.57911   18.78159  41.33799  1.000 15.29442  ? 107 THR E O   1 
ATOM   2869 C  CB  . THR C 1 71  ? 4.80068   17.90433  43.62475  1.000 15.42265  ? 107 THR E CB  1 
ATOM   2870 O  OG1 . THR C 1 71  ? 4.14958   16.91479  44.44122  1.000 18.09386  ? 107 THR E OG1 1 
ATOM   2871 C  CG2 . THR C 1 71  ? 4.06853   19.24517  43.79690  1.000 15.33539  ? 107 THR E CG2 1 
ATOM   2872 N  N   . LEU C 1 72  ? 4.54592   19.11950  40.40379  1.000 13.35397  ? 108 LEU E N   1 
ATOM   2873 C  CA  . LEU C 1 72  ? 5.04371   19.95932  39.31558  1.000 10.15616  ? 108 LEU E CA  1 
ATOM   2874 C  C   . LEU C 1 72  ? 4.13576   21.16225  39.10691  1.000 11.82893  ? 108 LEU E C   1 
ATOM   2875 O  O   . LEU C 1 72  ? 2.92277   21.00026  39.01424  1.000 12.72573  ? 108 LEU E O   1 
ATOM   2876 C  CB  . LEU C 1 72  ? 5.06514   19.19326  37.98788  1.000 13.35474  ? 108 LEU E CB  1 
ATOM   2877 C  CG  . LEU C 1 72  ? 6.15298   18.14042  37.83084  1.000 13.27247  ? 108 LEU E CG  1 
ATOM   2878 C  CD1 . LEU C 1 72  ? 5.78160   17.14532  36.71035  1.000 14.77002  ? 108 LEU E CD1 1 
ATOM   2879 C  CD2 . LEU C 1 72  ? 7.46338   18.86844  37.49346  1.000 12.86159  ? 108 LEU E CD2 1 
ATOM   2880 N  N   . TRP C 1 73  ? 4.72213   22.35161  38.97259  1.000 12.53063  ? 109 TRP E N   1 
ATOM   2881 C  CA  . TRP C 1 73  ? 3.95175   23.47926  38.45040  1.000 12.34205  ? 109 TRP E CA  1 
ATOM   2882 C  C   . TRP C 1 73  ? 3.54983   23.20192  37.00905  1.000 15.26713  ? 109 TRP E C   1 
ATOM   2883 O  O   . TRP C 1 73  ? 4.36183   22.72989  36.21312  1.000 13.74293  ? 109 TRP E O   1 
ATOM   2884 C  CB  . TRP C 1 73  ? 4.79935   24.74650  38.44599  1.000 12.17087  ? 109 TRP E CB  1 
ATOM   2885 C  CG  . TRP C 1 73  ? 5.03546   25.44490  39.75089  1.000 12.61376  ? 109 TRP E CG  1 
ATOM   2886 C  CD1 . TRP C 1 73  ? 6.25501   25.93952  40.19774  1.000 13.04903  ? 109 TRP E CD1 1 
ATOM   2887 C  CD2 . TRP C 1 73  ? 4.05060   25.90559  40.69831  1.000 15.75239  ? 109 TRP E CD2 1 
ATOM   2888 N  NE1 . TRP C 1 73  ? 6.07898   26.60640  41.38481  1.000 15.92189  ? 109 TRP E NE1 1 
ATOM   2889 C  CE2 . TRP C 1 73  ? 4.74898   26.61368  41.71432  1.000 14.35424  ? 109 TRP E CE2 1 
ATOM   2890 C  CE3 . TRP C 1 73  ? 2.65904   25.74960  40.81712  1.000 12.95642  ? 109 TRP E CE3 1 
ATOM   2891 C  CZ2 . TRP C 1 73  ? 4.09844   27.19003  42.82446  1.000 14.03245  ? 109 TRP E CZ2 1 
ATOM   2892 C  CZ3 . TRP C 1 73  ? 2.00285   26.33521  41.92515  1.000 16.57599  ? 109 TRP E CZ3 1 
ATOM   2893 C  CH2 . TRP C 1 73  ? 2.72961   27.04723  42.90761  1.000 14.30909  ? 109 TRP E CH2 1 
ATOM   2894 N  N   . ILE C 1 74  ? 2.31412   23.54163  36.66514  1.000 11.36142  ? 110 ILE E N   1 
ATOM   2895 C  CA  . ILE C 1 74  ? 1.85984   23.47009  35.28284  1.000 13.66181  ? 110 ILE E CA  1 
ATOM   2896 C  C   . ILE C 1 74  ? 1.27058   24.81671  34.87916  1.000 13.75104  ? 110 ILE E C   1 
ATOM   2897 O  O   . ILE C 1 74  ? 1.12185   25.73181  35.68848  1.000 14.50292  ? 110 ILE E O   1 
ATOM   2898 C  CB  . ILE C 1 74  ? 0.84323   22.33042  35.06263  1.000 12.93583  ? 110 ILE E CB  1 
ATOM   2899 C  CG1 . ILE C 1 74  ? -0.42405  22.57443  35.88171  1.000 14.37806  ? 110 ILE E CG1 1 
ATOM   2900 C  CG2 . ILE C 1 74  ? 1.51202   20.96809  35.30591  1.000 15.08952  ? 110 ILE E CG2 1 
ATOM   2901 C  CD1 . ILE C 1 74  ? -1.54326  21.56821  35.51000  1.000 16.13823  ? 110 ILE E CD1 1 
ATOM   2902 N  N   . GLY C 1 75  ? 0.97577   24.94146  33.58432  1.000 13.05130  ? 111 GLY E N   1 
ATOM   2903 C  CA  . GLY C 1 75  ? 0.68378   26.25008  33.02100  1.000 15.32281  ? 111 GLY E CA  1 
ATOM   2904 C  C   . GLY C 1 75  ? -0.75625  26.71366  33.13345  1.000 14.67696  ? 111 GLY E C   1 
ATOM   2905 O  O   . GLY C 1 75  ? -1.33325  27.15141  32.14778  1.000 15.89776  ? 111 GLY E O   1 
ATOM   2906 N  N   . LEU C 1 76  ? -1.33039  26.66158  34.33293  1.000 14.29823  ? 112 LEU E N   1 
ATOM   2907 C  CA  . LEU C 1 76  ? -2.71863  27.05713  34.54478  1.000 12.42658  ? 112 LEU E CA  1 
ATOM   2908 C  C   . LEU C 1 76  ? -2.71062  28.08048  35.66721  1.000 14.77477  ? 112 LEU E C   1 
ATOM   2909 O  O   . LEU C 1 76  ? -2.03171  27.87244  36.67319  1.000 15.26860  ? 112 LEU E O   1 
ATOM   2910 C  CB  . LEU C 1 76  ? -3.58051  25.83671  34.89403  1.000 12.50121  ? 112 LEU E CB  1 
ATOM   2911 C  CG  . LEU C 1 76  ? -5.08591  26.09271  35.07516  1.000 11.96207  ? 112 LEU E CG  1 
ATOM   2912 C  CD1 . LEU C 1 76  ? -5.63470  26.57434  33.71127  1.000 13.90511  ? 112 LEU E CD1 1 
ATOM   2913 C  CD2 . LEU C 1 76  ? -5.76986  24.79347  35.48225  1.000 13.91671  ? 112 LEU E CD2 1 
ATOM   2914 N  N   . MET C 1 77  ? -3.41233  29.19649  35.47847  1.000 14.43333  ? 113 MET E N   1 
ATOM   2915 C  CA  . MET C 1 77  ? -3.37728  30.27359  36.45626  1.000 13.80717  ? 113 MET E CA  1 
ATOM   2916 C  C   . MET C 1 77  ? -4.76736  30.88684  36.55977  1.000 13.39663  ? 113 MET E C   1 
ATOM   2917 O  O   . MET C 1 77  ? -5.51804  30.94608  35.58680  1.000 15.49643  ? 113 MET E O   1 
ATOM   2918 C  CB  . MET C 1 77  ? -2.34249  31.35186  36.08836  1.000 16.42481  ? 113 MET E CB  1 
ATOM   2919 C  CG  . MET C 1 77  ? -2.06640  32.33099  37.24484  1.000 24.60095  ? 113 MET E CG  1 
ATOM   2920 S  SD  . MET C 1 77  ? -0.88431  33.66663  36.91775  1.000 30.73625  ? 113 MET E SD  1 
ATOM   2921 C  CE  . MET C 1 77  ? -1.12400  34.61267  38.43110  1.000 29.81029  ? 113 MET E CE  1 
ATOM   2922 N  N   . GLU C 1 78  ? -5.09273  31.34107  37.75282  1.000 12.83615  ? 114 GLU E N   1 
ATOM   2923 C  CA  . GLU C 1 78  ? -6.38434  31.96855  37.99570  1.000 13.73543  ? 114 GLU E CA  1 
ATOM   2924 C  C   . GLU C 1 78  ? -6.47387  33.30634  37.27186  1.000 18.24174  ? 114 GLU E C   1 
ATOM   2925 O  O   . GLU C 1 78  ? -5.47671  34.00956  37.09438  1.000 17.40571  ? 114 GLU E O   1 
ATOM   2926 C  CB  . GLU C 1 78  ? -6.54951  32.17169  39.50516  1.000 13.72487  ? 114 GLU E CB  1 
ATOM   2927 C  CG  . GLU C 1 78  ? -7.96518  32.55747  39.90842  1.000 14.77417  ? 114 GLU E CG  1 
ATOM   2928 C  CD  . GLU C 1 78  ? -8.15755  32.61407  41.40273  1.000 16.99549  ? 114 GLU E CD  1 
ATOM   2929 O  OE1 . GLU C 1 78  ? -7.17844  32.37181  42.14875  1.000 17.45408  ? 114 GLU E OE1 1 
ATOM   2930 O  OE2 . GLU C 1 78  ? -9.30777  32.88000  41.83990  1.000 16.66096  ? 114 GLU E OE2 1 
ATOM   2931 N  N   . GLN C 1 79  ? -7.68473  33.67638  36.86386  1.000 15.67060  ? 115 GLN E N   1 
ATOM   2932 C  CA  . GLN C 1 79  ? -7.90262  35.01380  36.31041  1.000 20.47977  ? 115 GLN E CA  1 
ATOM   2933 C  C   . GLN C 1 79  ? -8.21201  35.93519  37.48343  1.000 18.88069  ? 115 GLN E C   1 
ATOM   2934 O  O   . GLN C 1 79  ? -9.30674  35.88064  38.05055  1.000 20.48340  ? 115 GLN E O   1 
ATOM   2935 C  CB  . GLN C 1 79  ? -9.02451  34.99382  35.28036  1.000 25.25961  ? 115 GLN E CB  1 
ATOM   2936 C  CG  . GLN C 1 79  ? -8.75530  33.99811  34.15652  1.000 27.43868  ? 115 GLN E CG  1 
ATOM   2937 C  CD  . GLN C 1 79  ? -9.83425  33.99975  33.08967  1.000 38.79099  ? 115 GLN E CD  1 
ATOM   2938 O  OE1 . GLN C 1 79  ? -9.73843  34.72263  32.09320  1.000 40.09746  ? 115 GLN E OE1 1 
ATOM   2939 N  NE2 . GLN C 1 79  ? -10.88150 33.21259  33.30640  1.000 32.15775  ? 115 GLN E NE2 1 
ATOM   2940 N  N   . ARG C 1 80  ? -7.22895  36.75189  37.87749  1.000 20.10091  ? 116 ARG E N   1 
ATOM   2941 C  CA  . ARG C 1 80  ? -7.32095  37.62121  39.06691  1.000 23.43928  ? 116 ARG E CA  1 
ATOM   2942 C  C   . ARG C 1 80  ? -7.78313  36.76585  40.24898  1.000 23.65294  ? 116 ARG E C   1 
ATOM   2943 O  O   . ARG C 1 80  ? -7.15729  35.73381  40.53448  1.000 22.68850  ? 116 ARG E O   1 
ATOM   2944 C  CB  . ARG C 1 80  ? -8.21275  38.81117  38.73268  1.000 23.64611  ? 116 ARG E CB  1 
ATOM   2945 C  CG  . ARG C 1 80  ? -7.70857  39.63965  37.56360  1.000 33.04019  ? 116 ARG E CG  1 
ATOM   2946 C  CD  . ARG C 1 80  ? -8.70546  40.71248  37.13847  1.000 45.57196  ? 116 ARG E CD  1 
ATOM   2947 N  NE  . ARG C 1 80  ? -10.00426 40.17314  36.73716  1.000 58.39603  ? 116 ARG E NE  1 
ATOM   2948 C  CZ  . ARG C 1 80  ? -10.22200 39.45718  35.63936  1.000 56.74420  ? 116 ARG E CZ  1 
ATOM   2949 N  NH1 . ARG C 1 80  ? -9.24008  39.14940  34.80376  1.000 50.64971  ? 116 ARG E NH1 1 
ATOM   2950 N  NH2 . ARG C 1 80  ? -11.45801 39.04436  35.36862  1.000 55.23546  ? 116 ARG E NH2 1 
ATOM   2951 N  N   . SER C 1 81  ? -8.85223  37.14652  40.95615  1.000 19.09350  ? 117 SER E N   1 
ATOM   2952 C  CA  . SER C 1 81  ? -9.38497  36.35715  42.06080  1.000 18.42833  ? 117 SER E CA  1 
ATOM   2953 C  C   . SER C 1 81  ? -10.72004 35.71808  41.71553  1.000 16.85083  ? 117 SER E C   1 
ATOM   2954 O  O   . SER C 1 81  ? -11.46410 35.32636  42.62168  1.000 17.88833  ? 117 SER E O   1 
ATOM   2955 C  CB  . SER C 1 81  ? -9.54591  37.21664  43.31866  1.000 21.20465  ? 117 SER E CB  1 
ATOM   2956 O  OG  . SER C 1 81  ? -8.33878  37.86034  43.65756  1.000 24.10306  ? 117 SER E OG  1 
ATOM   2957 N  N   . GLU C 1 82  ? -11.02172 35.57348  40.42380  1.000 17.31467  ? 118 GLU E N   1 
ATOM   2958 C  CA  . GLU C 1 82  ? -12.35210 35.18123  39.97102  1.000 19.11415  ? 118 GLU E CA  1 
ATOM   2959 C  C   . GLU C 1 82  ? -12.64552 33.69786  40.10286  1.000 18.07249  ? 118 GLU E C   1 
ATOM   2960 O  O   . GLU C 1 82  ? -13.78859 33.29333  39.85306  1.000 17.04995  ? 118 GLU E O   1 
ATOM   2961 C  CB  . GLU C 1 82  ? -12.54753 35.59790  38.51190  1.000 20.64188  ? 118 GLU E CB  1 
ATOM   2962 C  CG  . GLU C 1 82  ? -12.52435 37.08422  38.34535  1.000 23.10841  ? 118 GLU E CG  1 
ATOM   2963 C  CD  . GLU C 1 82  ? -13.71625 37.69615  39.06700  1.000 26.30385  ? 118 GLU E CD  1 
ATOM   2964 O  OE1 . GLU C 1 82  ? -14.86056 37.56552  38.57518  1.000 27.47600  ? 118 GLU E OE1 1 
ATOM   2965 O  OE2 . GLU C 1 82  ? -13.50274 38.23168  40.16414  1.000 23.64129  ? 118 GLU E OE2 1 
ATOM   2966 N  N   . ARG C 1 83  ? -11.66437 32.88281  40.49849  1.000 16.08230  ? 119 ARG E N   1 
ATOM   2967 C  CA  . ARG C 1 83  ? -11.84472 31.43228  40.56935  1.000 14.83260  ? 119 ARG E CA  1 
ATOM   2968 C  C   . ARG C 1 83  ? -12.27726 30.87658  39.21834  1.000 17.08878  ? 119 ARG E C   1 
ATOM   2969 O  O   . ARG C 1 83  ? -13.03224 29.90458  39.13408  1.000 17.18819  ? 119 ARG E O   1 
ATOM   2970 C  CB  . ARG C 1 83  ? -12.84172 31.03514  41.66060  1.000 16.09014  ? 119 ARG E CB  1 
ATOM   2971 C  CG  . ARG C 1 83  ? -12.41637 31.53554  43.05732  1.000 14.61740  ? 119 ARG E CG  1 
ATOM   2972 C  CD  . ARG C 1 83  ? -11.57077 30.49732  43.79163  1.000 16.71223  ? 119 ARG E CD  1 
ATOM   2973 N  NE  . ARG C 1 83  ? -10.15393 30.57148  43.41889  1.000 16.34737  ? 119 ARG E NE  1 
ATOM   2974 C  CZ  . ARG C 1 83  ? -9.24369  29.71329  43.86653  1.000 15.40359  ? 119 ARG E CZ  1 
ATOM   2975 N  NH1 . ARG C 1 83  ? -9.58969  28.65519  44.58275  1.000 15.14599  ? 119 ARG E NH1 1 
ATOM   2976 N  NH2 . ARG C 1 83  ? -7.95518  29.92362  43.59115  1.000 14.49065  ? 119 ARG E NH2 1 
ATOM   2977 N  N   . THR C 1 84  ? -11.80050 31.50878  38.16013  1.000 15.68497  ? 120 THR E N   1 
ATOM   2978 C  CA  . THR C 1 84  ? -11.85538 30.93579  36.83682  1.000 16.28359  ? 120 THR E CA  1 
ATOM   2979 C  C   . THR C 1 84  ? -10.40689 30.81685  36.39453  1.000 14.10088  ? 120 THR E C   1 
ATOM   2980 O  O   . THR C 1 84  ? -9.53249  31.49029  36.93595  1.000 16.09548  ? 120 THR E O   1 
ATOM   2981 C  CB  . THR C 1 84  ? -12.64369 31.81070  35.85778  1.000 18.07594  ? 120 THR E CB  1 
ATOM   2982 O  OG1 . THR C 1 84  ? -12.06809 33.11596  35.80824  1.000 21.01426  ? 120 THR E OG1 1 
ATOM   2983 C  CG2 . THR C 1 84  ? -14.10657 31.93381  36.33476  1.000 19.61851  ? 120 THR E CG2 1 
ATOM   2984 N  N   . TRP C 1 85  ? -10.16064 29.99812  35.38343  1.000 15.30501  ? 121 TRP E N   1 
ATOM   2985 C  CA  . TRP C 1 85  ? -8.80103  29.53561  35.13803  1.000 14.47008  ? 121 TRP E CA  1 
ATOM   2986 C  C   . TRP C 1 85  ? -8.47262  29.62873  33.66148  1.000 17.27244  ? 121 TRP E C   1 
ATOM   2987 O  O   . TRP C 1 85  ? -9.32438  29.37913  32.81360  1.000 17.45006  ? 121 TRP E O   1 
ATOM   2988 C  CB  . TRP C 1 85  ? -8.64269  28.08517  35.61322  1.000 16.30597  ? 121 TRP E CB  1 
ATOM   2989 C  CG  . TRP C 1 85  ? -8.97907  27.97825  37.05065  1.000 14.51423  ? 121 TRP E CG  1 
ATOM   2990 C  CD1 . TRP C 1 85  ? -10.20594 27.72446  37.59929  1.000 15.10938  ? 121 TRP E CD1 1 
ATOM   2991 C  CD2 . TRP C 1 85  ? -8.07622  28.18620  38.14449  1.000 15.35790  ? 121 TRP E CD2 1 
ATOM   2992 N  NE1 . TRP C 1 85  ? -10.10942 27.73746  38.98171  1.000 16.57764  ? 121 TRP E NE1 1 
ATOM   2993 C  CE2 . TRP C 1 85  ? -8.81490  28.02301  39.33456  1.000 15.06292  ? 121 TRP E CE2 1 
ATOM   2994 C  CE3 . TRP C 1 85  ? -6.70999  28.47745  38.22613  1.000 15.63181  ? 121 TRP E CE3 1 
ATOM   2995 C  CZ2 . TRP C 1 85  ? -8.23398  28.16311  40.60600  1.000 15.24613  ? 121 TRP E CZ2 1 
ATOM   2996 C  CZ3 . TRP C 1 85  ? -6.12691  28.61698  39.48228  1.000 16.18362  ? 121 TRP E CZ3 1 
ATOM   2997 C  CH2 . TRP C 1 85  ? -6.89150  28.45989  40.65928  1.000 13.90592  ? 121 TRP E CH2 1 
ATOM   2998 N  N   . ARG C 1 86  ? -7.21561  29.95259  33.36474  1.000 15.40382  ? 122 ARG E N   1 
ATOM   2999 C  CA  . ARG C 1 86  ? -6.79658  30.13170  31.98266  1.000 15.96767  ? 122 ARG E CA  1 
ATOM   3000 C  C   . ARG C 1 86  ? -5.40697  29.53466  31.80648  1.000 16.55459  ? 122 ARG E C   1 
ATOM   3001 O  O   . ARG C 1 86  ? -4.52524  29.76654  32.63922  1.000 17.67475  ? 122 ARG E O   1 
ATOM   3002 C  CB  . ARG C 1 86  ? -6.80140  31.62582  31.60893  1.000 20.91061  ? 122 ARG E CB  1 
ATOM   3003 C  CG  . ARG C 1 86  ? -6.85449  31.87012  30.10550  1.000 38.81905  ? 122 ARG E CG  1 
ATOM   3004 C  CD  . ARG C 1 86  ? -7.69284  33.12751  29.76594  1.000 42.88170  ? 122 ARG E CD  1 
ATOM   3005 N  NE  . ARG C 1 86  ? -9.05443  32.72957  29.40550  1.000 54.13866  ? 122 ARG E NE  1 
ATOM   3006 C  CZ  . ARG C 1 86  ? -9.64427  32.95435  28.23790  1.000 49.73726  ? 122 ARG E CZ  1 
ATOM   3007 N  NH1 . ARG C 1 86  ? -9.02418  33.59060  27.25797  1.000 60.61185  ? 122 ARG E NH1 1 
ATOM   3008 N  NH2 . ARG C 1 86  ? -10.89089 32.52717  28.04793  1.000 59.13571  ? 122 ARG E NH2 1 
ATOM   3009 N  N   . TRP C 1 87  ? -5.22208  28.76291  30.74083  1.000 16.59088  ? 123 TRP E N   1 
ATOM   3010 C  CA  . TRP C 1 87  ? -3.89628  28.23625  30.42001  1.000 14.91326  ? 123 TRP E CA  1 
ATOM   3011 C  C   . TRP C 1 87  ? -2.96773  29.34767  29.93523  1.000 16.16601  ? 123 TRP E C   1 
ATOM   3012 O  O   . TRP C 1 87  ? -3.40643  30.41353  29.49308  1.000 18.79879  ? 123 TRP E O   1 
ATOM   3013 C  CB  . TRP C 1 87  ? -4.00692  27.14238  29.34453  1.000 16.64019  ? 123 TRP E CB  1 
ATOM   3014 C  CG  . TRP C 1 87  ? -4.76976  25.93357  29.80877  1.000 16.25749  ? 123 TRP E CG  1 
ATOM   3015 C  CD1 . TRP C 1 87  ? -6.06076  25.59626  29.50949  1.000 18.27044  ? 123 TRP E CD1 1 
ATOM   3016 C  CD2 . TRP C 1 87  ? -4.27591  24.90954  30.67719  1.000 17.80040  ? 123 TRP E CD2 1 
ATOM   3017 N  NE1 . TRP C 1 87  ? -6.39019  24.40684  30.12240  1.000 17.97034  ? 123 TRP E NE1 1 
ATOM   3018 C  CE2 . TRP C 1 87  ? -5.30936  23.97056  30.84881  1.000 17.77671  ? 123 TRP E CE2 1 
ATOM   3019 C  CE3 . TRP C 1 87  ? -3.04968  24.70019  31.32743  1.000 15.39675  ? 123 TRP E CE3 1 
ATOM   3020 C  CZ2 . TRP C 1 87  ? -5.16284  22.83407  31.65106  1.000 18.08755  ? 123 TRP E CZ2 1 
ATOM   3021 C  CZ3 . TRP C 1 87  ? -2.89504  23.56231  32.11271  1.000 14.70607  ? 123 TRP E CZ3 1 
ATOM   3022 C  CH2 . TRP C 1 87  ? -3.94905  22.65001  32.27777  1.000 15.38569  ? 123 TRP E CH2 1 
ATOM   3023 N  N   . VAL C 1 88  ? -1.65808  29.07067  29.98058  1.000 14.00724  ? 124 VAL E N   1 
ATOM   3024 C  CA  . VAL C 1 88  ? -0.67755  30.10834  29.68336  1.000 14.55475  ? 124 VAL E CA  1 
ATOM   3025 C  C   . VAL C 1 88  ? -0.73586  30.55439  28.22474  1.000 18.88571  ? 124 VAL E C   1 
ATOM   3026 O  O   . VAL C 1 88  ? -0.24166  31.64090  27.90422  1.000 19.96759  ? 124 VAL E O   1 
ATOM   3027 C  CB  . VAL C 1 88  ? 0.75583   29.65781  30.02833  1.000 15.00159  ? 124 VAL E CB  1 
ATOM   3028 C  CG1 . VAL C 1 88  ? 0.96093   29.70738  31.54806  1.000 15.43719  ? 124 VAL E CG1 1 
ATOM   3029 C  CG2 . VAL C 1 88  ? 1.07900   28.23449  29.48783  1.000 14.36198  ? 124 VAL E CG2 1 
ATOM   3030 N  N   . ASP C 1 89  ? -1.31387  29.74794  27.33206  1.000 17.59449  ? 125 ASP E N   1 
ATOM   3031 C  CA  . ASP C 1 89  ? -1.50505  30.16759  25.94378  1.000 21.03191  ? 125 ASP E CA  1 
ATOM   3032 C  C   . ASP C 1 89  ? -2.78318  30.97150  25.75922  1.000 23.65481  ? 125 ASP E C   1 
ATOM   3033 O  O   . ASP C 1 89  ? -3.16146  31.28162  24.62203  1.000 22.62430  ? 125 ASP E O   1 
ATOM   3034 C  CB  . ASP C 1 89  ? -1.51324  28.95229  25.00532  1.000 21.46597  ? 125 ASP E CB  1 
ATOM   3035 C  CG  . ASP C 1 89  ? -2.69932  28.02589  25.23537  1.000 25.01710  ? 125 ASP E CG  1 
ATOM   3036 O  OD1 . ASP C 1 89  ? -3.48863  28.24035  26.18761  1.000 23.09853  ? 125 ASP E OD1 1 
ATOM   3037 O  OD2 . ASP C 1 89  ? -2.82721  27.04159  24.47071  1.000 27.56456  ? 125 ASP E OD2 1 
ATOM   3038 N  N   . GLY C 1 90  ? -3.46180  31.29245  26.84637  1.000 19.24804  ? 126 GLY E N   1 
ATOM   3039 C  CA  . GLY C 1 90  ? -4.67212  32.09034  26.78725  1.000 24.39207  ? 126 GLY E CA  1 
ATOM   3040 C  C   . GLY C 1 90  ? -5.96185  31.31447  26.63524  1.000 24.82057  ? 126 GLY E C   1 
ATOM   3041 O  O   . GLY C 1 90  ? -7.03741  31.93012  26.66162  1.000 28.36589  ? 126 GLY E O   1 
ATOM   3042 N  N   . THR C 1 91  ? -5.90508  29.98403  26.50951  1.000 20.37736  ? 127 THR E N   1 
ATOM   3043 C  CA  . THR C 1 91  ? -7.16140  29.26083  26.34296  1.000 24.56517  ? 127 THR E CA  1 
ATOM   3044 C  C   . THR C 1 91  ? -7.85252  29.05413  27.69253  1.000 27.06266  ? 127 THR E C   1 
ATOM   3045 O  O   . THR C 1 91  ? -7.19196  28.86090  28.71775  1.000 21.36481  ? 127 THR E O   1 
ATOM   3046 C  CB  . THR C 1 91  ? -6.92210  27.90341  25.68999  1.000 28.07200  ? 127 THR E CB  1 
ATOM   3047 O  OG1 . THR C 1 91  ? -5.92249  27.20280  26.42122  1.000 26.76219  ? 127 THR E OG1 1 
ATOM   3048 C  CG2 . THR C 1 91  ? -6.40447  28.09014  24.28296  1.000 31.42331  ? 127 THR E CG2 1 
ATOM   3049 N  N   . PRO C 1 92  ? -9.18016  29.09259  27.72010  1.000 25.24558  ? 128 PRO E N   1 
ATOM   3050 C  CA  . PRO C 1 92  ? -9.88915  28.91487  28.98581  1.000 25.29710  ? 128 PRO E CA  1 
ATOM   3051 C  C   . PRO C 1 92  ? -9.84677  27.46304  29.41163  1.000 20.27303  ? 128 PRO E C   1 
ATOM   3052 O  O   . PRO C 1 92  ? -9.73816  26.54400  28.59730  1.000 22.59848  ? 128 PRO E O   1 
ATOM   3053 C  CB  . PRO C 1 92  ? -11.32540 29.35195  28.66090  1.000 31.93527  ? 128 PRO E CB  1 
ATOM   3054 C  CG  . PRO C 1 92  ? -11.46883 29.08993  27.19351  1.000 30.71178  ? 128 PRO E CG  1 
ATOM   3055 C  CD  . PRO C 1 92  ? -10.10154 29.37973  26.60198  1.000 32.06535  ? 128 PRO E CD  1 
ATOM   3056 N  N   . LEU C 1 93  ? -9.91700  27.25919  30.71705  1.000 21.83151  ? 129 LEU E N   1 
ATOM   3057 C  CA  . LEU C 1 93  ? -9.98531  25.89949  31.21927  1.000 18.66133  ? 129 LEU E CA  1 
ATOM   3058 C  C   . LEU C 1 93  ? -11.28585 25.25114  30.75678  1.000 20.22454  ? 129 LEU E C   1 
ATOM   3059 O  O   . LEU C 1 93  ? -12.36008 25.83819  30.89100  1.000 22.06389  ? 129 LEU E O   1 
ATOM   3060 C  CB  . LEU C 1 93  ? -9.89478  25.91383  32.74231  1.000 16.73611  ? 129 LEU E CB  1 
ATOM   3061 C  CG  . LEU C 1 93  ? -10.07843 24.56085  33.43430  1.000 18.82703  ? 129 LEU E CG  1 
ATOM   3062 C  CD1 . LEU C 1 93  ? -8.92015  23.64674  33.08165  1.000 18.12667  ? 129 LEU E CD1 1 
ATOM   3063 C  CD2 . LEU C 1 93  ? -10.17963 24.76242  34.95549  1.000 19.79624  ? 129 LEU E CD2 1 
ATOM   3064 N  N   . THR C 1 94  ? -11.18510 24.05926  30.16925  1.000 18.79261  ? 130 THR E N   1 
ATOM   3065 C  CA  . THR C 1 94  ? -12.38676 23.26582  29.95138  1.000 22.99411  ? 130 THR E CA  1 
ATOM   3066 C  C   . THR C 1 94  ? -12.31437 21.99294  30.78530  1.000 23.68421  ? 130 THR E C   1 
ATOM   3067 O  O   . THR C 1 94  ? -12.77025 21.98431  31.93440  1.000 29.70492  ? 130 THR E O   1 
ATOM   3068 C  CB  . THR C 1 94  ? -12.58509 22.96627  28.45991  1.000 24.93804  ? 130 THR E CB  1 
ATOM   3069 O  OG1 . THR C 1 94  ? -11.37355 22.44283  27.91137  1.000 29.30697  ? 130 THR E OG1 1 
ATOM   3070 C  CG2 . THR C 1 94  ? -12.94165 24.24739  27.72385  1.000 28.87561  ? 130 THR E CG2 1 
ATOM   3071 N  N   . GLU C 1 95  ? -11.73473 20.92699  30.24533  1.000 23.58196  ? 131 GLU E N   1 
ATOM   3072 C  CA  . GLU C 1 95  ? -11.63195 19.68830  31.00606  1.000 22.99759  ? 131 GLU E CA  1 
ATOM   3073 C  C   . GLU C 1 95  ? -10.59052 19.85116  32.10758  1.000 24.34565  ? 131 GLU E C   1 
ATOM   3074 O  O   . GLU C 1 95  ? -9.51597  20.41838  31.89203  1.000 20.81106  ? 131 GLU E O   1 
ATOM   3075 C  CB  . GLU C 1 95  ? -11.26382 18.52113  30.08974  1.000 29.20424  ? 131 GLU E CB  1 
ATOM   3076 C  CG  . GLU C 1 95  ? -12.14616 18.43131  28.83648  1.000 33.62641  ? 131 GLU E CG  1 
ATOM   3077 C  CD  . GLU C 1 95  ? -11.94955 17.13664  28.06592  1.000 53.05357  ? 131 GLU E CD  1 
ATOM   3078 O  OE1 . GLU C 1 95  ? -12.96483 16.48240  27.73014  1.000 53.19173  ? 131 GLU E OE1 1 
ATOM   3079 O  OE2 . GLU C 1 95  ? -10.78034 16.76814  27.80694  1.000 47.17772  ? 131 GLU E OE2 1 
ATOM   3080 N  N   . SER C 1 96  ? -10.92958 19.38864  33.30330  1.000 22.20076  ? 132 SER E N   1 
ATOM   3081 C  CA  . SER C 1 96  ? -10.10087 19.64822  34.46956  1.000 20.06511  ? 132 SER E CA  1 
ATOM   3082 C  C   . SER C 1 96  ? -9.84386  18.35009  35.22085  1.000 17.47719  ? 132 SER E C   1 
ATOM   3083 O  O   . SER C 1 96  ? -10.59624 17.37217  35.09838  1.000 17.05282  ? 132 SER E O   1 
ATOM   3084 C  CB  . SER C 1 96  ? -10.75886 20.69383  35.39302  1.000 21.44389  ? 132 SER E CB  1 
ATOM   3085 O  OG  . SER C 1 96  ? -11.98026 20.18008  35.91193  1.000 20.88139  ? 132 SER E OG  1 
ATOM   3086 N  N   . TYR C 1 97  ? -8.76016  18.35007  36.00420  1.000 18.83497  ? 133 TYR E N   1 
ATOM   3087 C  CA  . TYR C 1 97  ? -8.33124  17.17420  36.76036  1.000 16.77975  ? 133 TYR E CA  1 
ATOM   3088 C  C   . TYR C 1 97  ? -7.94577  17.56967  38.18145  1.000 16.94752  ? 133 TYR E C   1 
ATOM   3089 O  O   . TYR C 1 97  ? -6.93960  17.10425  38.72880  1.000 16.18967  ? 133 TYR E O   1 
ATOM   3090 C  CB  . TYR C 1 97  ? -7.16999  16.46273  36.05981  1.000 16.70578  ? 133 TYR E CB  1 
ATOM   3091 C  CG  . TYR C 1 97  ? -7.57109  16.05076  34.66732  1.000 16.21859  ? 133 TYR E CG  1 
ATOM   3092 C  CD1 . TYR C 1 97  ? -8.33245  14.90211  34.46585  1.000 21.84453  ? 133 TYR E CD1 1 
ATOM   3093 C  CD2 . TYR C 1 97  ? -7.24763  16.83201  33.57880  1.000 19.31286  ? 133 TYR E CD2 1 
ATOM   3094 C  CE1 . TYR C 1 97  ? -8.73284  14.53301  33.19376  1.000 26.04717  ? 133 TYR E CE1 1 
ATOM   3095 C  CE2 . TYR C 1 97  ? -7.63991  16.47779  32.30488  1.000 21.07892  ? 133 TYR E CE2 1 
ATOM   3096 C  CZ  . TYR C 1 97  ? -8.37991  15.32345  32.11815  1.000 25.44406  ? 133 TYR E CZ  1 
ATOM   3097 O  OH  . TYR C 1 97  ? -8.78198  14.97953  30.84480  1.000 29.99849  ? 133 TYR E OH  1 
ATOM   3098 N  N   . TRP C 1 98  ? -8.78083  18.41482  38.79686  1.000 16.22226  ? 134 TRP E N   1 
ATOM   3099 C  CA  . TRP C 1 98  ? -8.55426  18.84305  40.17203  1.000 15.67759  ? 134 TRP E CA  1 
ATOM   3100 C  C   . TRP C 1 98  ? -8.55220  17.66726  41.13055  1.000 23.91454  ? 134 TRP E C   1 
ATOM   3101 O  O   . TRP C 1 98  ? -9.37821  16.75378  41.03588  1.000 20.17056  ? 134 TRP E O   1 
ATOM   3102 C  CB  . TRP C 1 98  ? -9.63838  19.82981  40.63953  1.000 17.26881  ? 134 TRP E CB  1 
ATOM   3103 C  CG  . TRP C 1 98  ? -9.70343  21.12346  39.87913  1.000 15.13214  ? 134 TRP E CG  1 
ATOM   3104 C  CD1 . TRP C 1 98  ? -10.67999 21.51583  38.99907  1.000 18.41464  ? 134 TRP E CD1 1 
ATOM   3105 C  CD2 . TRP C 1 98  ? -8.75992  22.20486  39.94227  1.000 16.04549  ? 134 TRP E CD2 1 
ATOM   3106 N  NE1 . TRP C 1 98  ? -10.39401 22.77393  38.50938  1.000 19.46630  ? 134 TRP E NE1 1 
ATOM   3107 C  CE2 . TRP C 1 98  ? -9.22219  23.21614  39.07117  1.000 15.08732  ? 134 TRP E CE2 1 
ATOM   3108 C  CE3 . TRP C 1 98  ? -7.57463  22.41982  40.66305  1.000 18.11280  ? 134 TRP E CE3 1 
ATOM   3109 C  CZ2 . TRP C 1 98  ? -8.54414  24.42871  38.89719  1.000 15.85730  ? 134 TRP E CZ2 1 
ATOM   3110 C  CZ3 . TRP C 1 98  ? -6.88447  23.63430  40.47708  1.000 14.72765  ? 134 TRP E CZ3 1 
ATOM   3111 C  CH2 . TRP C 1 98  ? -7.37649  24.61672  39.59738  1.000 16.48767  ? 134 TRP E CH2 1 
ATOM   3112 N  N   . SER C 1 99  ? -7.64144  17.72139  42.08710  1.000 16.64052  ? 135 SER E N   1 
ATOM   3113 C  CA  A SER C 1 99  ? -7.64153  16.71778  43.12687  0.649 19.57052  ? 135 SER E CA  1 
ATOM   3114 C  CA  B SER C 1 99  ? -7.62818  16.73113  43.13707  0.351 19.58296  ? 135 SER E CA  1 
ATOM   3115 C  C   . SER C 1 99  ? -8.79756  16.99348  44.08094  1.000 25.05037  ? 135 SER E C   1 
ATOM   3116 O  O   . SER C 1 99  ? -9.39751  18.08143  44.07940  1.000 22.31081  ? 135 SER E O   1 
ATOM   3117 C  CB  A SER C 1 99  ? -6.31035  16.70424  43.87039  0.649 21.46102  ? 135 SER E CB  1 
ATOM   3118 C  CB  B SER C 1 99  ? -6.29481  16.76894  43.87422  0.351 21.41908  ? 135 SER E CB  1 
ATOM   3119 O  OG  A SER C 1 99  ? -6.08145  17.93455  44.51810  0.649 23.60931  ? 135 SER E OG  1 
ATOM   3120 O  OG  B SER C 1 99  ? -6.13610  15.60291  44.65166  0.351 30.59426  ? 135 SER E OG  1 
ATOM   3121 N  N   . LEU C 1 100 ? -9.13614  15.97780  44.87493  1.000 22.14926  ? 136 LEU E N   1 
ATOM   3122 C  CA  . LEU C 1 100 ? -10.30972 16.05953  45.74368  1.000 26.09631  ? 136 LEU E CA  1 
ATOM   3123 C  C   . LEU C 1 100 ? -10.28038 17.31096  46.61097  1.000 22.90354  ? 136 LEU E C   1 
ATOM   3124 O  O   . LEU C 1 100 ? -9.29871  17.58250  47.30050  1.000 28.03438  ? 136 LEU E O   1 
ATOM   3125 C  CB  . LEU C 1 100 ? -10.39036 14.81316  46.63532  1.000 29.47840  ? 136 LEU E CB  1 
ATOM   3126 C  CG  . LEU C 1 100 ? -11.73867 14.51945  47.30899  1.000 40.59436  ? 136 LEU E CG  1 
ATOM   3127 C  CD1 . LEU C 1 100 ? -12.92984 14.87813  46.41395  1.000 35.62784  ? 136 LEU E CD1 1 
ATOM   3128 C  CD2 . LEU C 1 100 ? -11.82349 13.07788  47.82937  1.000 38.66584  ? 136 LEU E CD2 1 
ATOM   3129 N  N   . GLY C 1 101 ? -11.36760 18.07812  46.56658  1.000 23.44696  ? 137 GLY E N   1 
ATOM   3130 C  CA  . GLY C 1 101 ? -11.48720 19.27918  47.36009  1.000 26.02810  ? 137 GLY E CA  1 
ATOM   3131 C  C   . GLY C 1 101 ? -10.80826 20.49888  46.77961  1.000 20.10344  ? 137 GLY E C   1 
ATOM   3132 O  O   . GLY C 1 101 ? -10.85878 21.56740  47.39842  1.000 20.67453  ? 137 GLY E O   1 
ATOM   3133 N  N   . GLU C 1 102 ? -10.18740 20.38665  45.61173  1.000 16.96320  ? 138 GLU E N   1 
ATOM   3134 C  CA  . GLU C 1 102 ? -9.52627  21.54406  45.02794  1.000 15.86979  ? 138 GLU E CA  1 
ATOM   3135 C  C   . GLU C 1 102 ? -10.34227 22.08150  43.85657  1.000 18.21862  ? 138 GLU E C   1 
ATOM   3136 O  O   . GLU C 1 102 ? -11.14376 21.34938  43.25834  1.000 19.73023  ? 138 GLU E O   1 
ATOM   3137 C  CB  . GLU C 1 102 ? -8.12395  21.15627  44.54660  1.000 17.25721  ? 138 GLU E CB  1 
ATOM   3138 C  CG  . GLU C 1 102 ? -7.24862  20.55183  45.67333  1.000 17.15516  ? 138 GLU E CG  1 
ATOM   3139 C  CD  . GLU C 1 102 ? -6.94525  21.49849  46.81507  1.000 18.91826  ? 138 GLU E CD  1 
ATOM   3140 O  OE1 . GLU C 1 102 ? -7.08090  22.72372  46.63684  1.000 17.42334  ? 138 GLU E OE1 1 
ATOM   3141 O  OE2 . GLU C 1 102 ? -6.51308  21.01138  47.90839  1.000 18.80158  ? 138 GLU E OE2 1 
ATOM   3142 N  N   . PRO C 1 103 ? -10.16106 23.36093  43.49139  1.000 16.24955  ? 139 PRO E N   1 
ATOM   3143 C  CA  . PRO C 1 103 ? -9.29619  24.38449  44.11253  1.000 14.16557  ? 139 PRO E CA  1 
ATOM   3144 C  C   . PRO C 1 103 ? -9.99225  25.00575  45.30444  1.000 18.68419  ? 139 PRO E C   1 
ATOM   3145 O  O   . PRO C 1 103 ? -11.23870 25.01668  45.36715  1.000 16.78535  ? 139 PRO E O   1 
ATOM   3146 C  CB  . PRO C 1 103 ? -9.08058  25.39333  42.97953  1.000 17.13747  ? 139 PRO E CB  1 
ATOM   3147 C  CG  . PRO C 1 103 ? -10.41568 25.35026  42.22757  1.000 17.04577  ? 139 PRO E CG  1 
ATOM   3148 C  CD  . PRO C 1 103 ? -10.84665 23.88949  42.29068  1.000 15.24303  ? 139 PRO E CD  1 
ATOM   3149 N  N   . ASN C 1 104 ? -9.23898  25.53727  46.26804  1.000 16.21195  ? 140 ASN E N   1 
ATOM   3150 C  CA  . ASN C 1 104 ? -9.84959  25.84880  47.55310  1.000 16.96437  ? 140 ASN E CA  1 
ATOM   3151 C  C   . ASN C 1 104 ? -9.36092  27.10677  48.25634  1.000 16.29395  ? 140 ASN E C   1 
ATOM   3152 O  O   . ASN C 1 104 ? -9.91778  27.42490  49.31592  1.000 21.40741  ? 140 ASN E O   1 
ATOM   3153 C  CB  . ASN C 1 104 ? -9.68245  24.65123  48.51877  1.000 18.90773  ? 140 ASN E CB  1 
ATOM   3154 C  CG  . ASN C 1 104 ? -8.22060  24.42259  48.96172  1.000 19.77485  ? 140 ASN E CG  1 
ATOM   3155 O  OD1 . ASN C 1 104 ? -7.26953  25.02453  48.42981  1.000 15.80646  ? 140 ASN E OD1 1 
ATOM   3156 N  ND2 . ASN C 1 104 ? -8.04725  23.52986  49.93877  1.000 18.78279  ? 140 ASN E ND2 1 
ATOM   3157 N  N   . ASN C 1 105 ? -8.36642  27.83120  47.73068  1.000 14.97423  ? 141 ASN E N   1 
ATOM   3158 C  CA  . ASN C 1 105 ? -7.77208  28.98460  48.42232  1.000 16.50944  ? 141 ASN E CA  1 
ATOM   3159 C  C   . ASN C 1 105 ? -7.55620  28.64341  49.89137  1.000 19.57868  ? 141 ASN E C   1 
ATOM   3160 O  O   . ASN C 1 105 ? -8.11786  29.27314  50.79284  1.000 21.52816  ? 141 ASN E O   1 
ATOM   3161 C  CB  . ASN C 1 105 ? -8.63968  30.24308  48.33266  1.000 15.44476  ? 141 ASN E CB  1 
ATOM   3162 C  CG  . ASN C 1 105 ? -8.46635  31.01008  47.04077  1.000 16.44851  ? 141 ASN E CG  1 
ATOM   3163 O  OD1 . ASN C 1 105 ? -7.36377  31.11500  46.48441  1.000 16.49526  ? 141 ASN E OD1 1 
ATOM   3164 N  ND2 . ASN C 1 105 ? -9.56319  31.57850  46.56368  1.000 14.05425  ? 141 ASN E ND2 1 
ATOM   3165 N  N   . TYR C 1 106 ? -6.75942  27.59351  50.09956  1.000 20.18362  ? 142 TYR E N   1 
ATOM   3166 C  CA  . TYR C 1 106 ? -6.56348  26.94886  51.40116  1.000 17.73605  ? 142 TYR E CA  1 
ATOM   3167 C  C   . TYR C 1 106 ? -6.39083  27.95222  52.53780  1.000 18.80297  ? 142 TYR E C   1 
ATOM   3168 O  O   . TYR C 1 106 ? -5.55117  28.85236  52.46784  1.000 19.39845  ? 142 TYR E O   1 
ATOM   3169 C  CB  . TYR C 1 106 ? -5.33024  26.04711  51.30910  1.000 18.21495  ? 142 TYR E CB  1 
ATOM   3170 C  CG  . TYR C 1 106 ? -5.07827  25.17854  52.52459  1.000 19.82834  ? 142 TYR E CG  1 
ATOM   3171 C  CD1 . TYR C 1 106 ? -5.99948  24.22199  52.92570  1.000 26.26728  ? 142 TYR E CD1 1 
ATOM   3172 C  CD2 . TYR C 1 106 ? -3.90208  25.31586  53.25667  1.000 28.61022  ? 142 TYR E CD2 1 
ATOM   3173 C  CE1 . TYR C 1 106 ? -5.75111  23.41084  54.04205  1.000 30.90353  ? 142 TYR E CE1 1 
ATOM   3174 C  CE2 . TYR C 1 106 ? -3.64463  24.51476  54.36127  1.000 27.07401  ? 142 TYR E CE2 1 
ATOM   3175 C  CZ  . TYR C 1 106 ? -4.57305  23.56943  54.74666  1.000 36.72917  ? 142 TYR E CZ  1 
ATOM   3176 O  OH  . TYR C 1 106 ? -4.31485  22.77807  55.84109  1.000 40.45256  ? 142 TYR E OH  1 
ATOM   3177 N  N   . GLU C 1 107 ? -7.22822  27.80206  53.57282  1.000 24.56802  ? 143 GLU E N   1 
ATOM   3178 C  CA  . GLU C 1 107 ? -7.16304  28.61094  54.79832  1.000 23.33579  ? 143 GLU E CA  1 
ATOM   3179 C  C   . GLU C 1 107 ? -7.27581  30.11060  54.50465  1.000 27.25012  ? 143 GLU E C   1 
ATOM   3180 O  O   . GLU C 1 107 ? -6.75785  30.95429  55.23740  1.000 26.20670  ? 143 GLU E O   1 
ATOM   3181 C  CB  . GLU C 1 107 ? -5.89001  28.27198  55.58678  1.000 28.43649  ? 143 GLU E CB  1 
ATOM   3182 C  CG  . GLU C 1 107 ? -5.84885  26.79157  55.96438  1.000 27.41652  ? 143 GLU E CG  1 
ATOM   3183 C  CD  . GLU C 1 107 ? -4.70215  26.42911  56.89816  1.000 45.84213  ? 143 GLU E CD  1 
ATOM   3184 O  OE1 . GLU C 1 107 ? -3.62734  27.06242  56.81744  1.000 35.75762  ? 143 GLU E OE1 1 
ATOM   3185 O  OE2 . GLU C 1 107 ? -4.88872  25.50688  57.71952  1.000 43.76521  ? 143 GLU E OE2 1 
ATOM   3186 N  N   . GLY C 1 108 ? -7.95701  30.46733  53.41835  1.000 18.97848  ? 144 GLY E N   1 
ATOM   3187 C  CA  . GLY C 1 108 ? -8.16163  31.85466  53.08848  1.000 19.71932  ? 144 GLY E CA  1 
ATOM   3188 C  C   . GLY C 1 108 ? -7.00805  32.52707  52.37655  1.000 20.51641  ? 144 GLY E C   1 
ATOM   3189 O  O   . GLY C 1 108 ? -7.08857  33.73044  52.10123  1.000 24.51170  ? 144 GLY E O   1 
ATOM   3190 N  N   . ARG C 1 109 ? -5.94359  31.80407  52.05995  1.000 23.28177  ? 145 ARG E N   1 
ATOM   3191 C  CA  . ARG C 1 109 ? -4.82848  32.44139  51.37948  1.000 25.52275  ? 145 ARG E CA  1 
ATOM   3192 C  C   . ARG C 1 109 ? -5.05000  32.42163  49.86507  1.000 19.76471  ? 145 ARG E C   1 
ATOM   3193 O  O   . ARG C 1 109 ? -5.75391  31.56028  49.33212  1.000 20.30098  ? 145 ARG E O   1 
ATOM   3194 C  CB  . ARG C 1 109 ? -3.50955  31.76199  51.75711  1.000 34.28557  ? 145 ARG E CB  1 
ATOM   3195 C  CG  . ARG C 1 109 ? -2.34376  32.74150  51.64107  1.000 51.74486  ? 145 ARG E CG  1 
ATOM   3196 C  CD  . ARG C 1 109 ? -1.17902  32.41411  52.56285  1.000 51.59098  ? 145 ARG E CD  1 
ATOM   3197 N  NE  . ARG C 1 109 ? 0.09039   32.76193  51.93478  1.000 53.62384  ? 145 ARG E NE  1 
ATOM   3198 C  CZ  . ARG C 1 109 ? 1.26662   32.26219  52.28635  1.000 53.76452  ? 145 ARG E CZ  1 
ATOM   3199 N  NH1 . ARG C 1 109 ? 1.37433   31.35740  53.24721  1.000 59.35926  ? 145 ARG E NH1 1 
ATOM   3200 N  NH2 . ARG C 1 109 ? 2.36124   32.67324  51.65060  1.000 55.11680  ? 145 ARG E NH2 1 
ATOM   3201 N  N   . GLN C 1 110 ? -4.46228  33.39629  49.17901  1.000 19.67232  ? 146 GLN E N   1 
ATOM   3202 C  CA  . GLN C 1 110 ? -4.63589  33.50118  47.73387  1.000 16.86482  ? 146 GLN E CA  1 
ATOM   3203 C  C   . GLN C 1 110 ? -3.80113  32.43696  47.03938  1.000 23.15616  ? 146 GLN E C   1 
ATOM   3204 O  O   . GLN C 1 110 ? -2.56496  32.48399  47.07915  1.000 23.75135  ? 146 GLN E O   1 
ATOM   3205 C  CB  . GLN C 1 110 ? -4.23107  34.88182  47.23640  1.000 21.55704  ? 146 GLN E CB  1 
ATOM   3206 C  CG  . GLN C 1 110 ? -4.55645  35.01141  45.79122  1.000 29.08630  ? 146 GLN E CG  1 
ATOM   3207 C  CD  . GLN C 1 110 ? -5.35430  36.25881  45.49932  1.000 47.90082  ? 146 GLN E CD  1 
ATOM   3208 O  OE1 . GLN C 1 110 ? -4.91444  37.36780  45.80901  1.000 37.15909  ? 146 GLN E OE1 1 
ATOM   3209 N  NE2 . GLN C 1 110 ? -6.58396  36.07825  44.99031  1.000 24.07777  ? 146 GLN E NE2 1 
ATOM   3210 N  N   . GLU C 1 111 ? -4.46456  31.49555  46.38055  1.000 16.80819  ? 147 GLU E N   1 
ATOM   3211 C  CA  . GLU C 1 111 ? -3.77686  30.39172  45.69884  1.000 15.90744  ? 147 GLU E CA  1 
ATOM   3212 C  C   . GLU C 1 111 ? -4.13899  30.49327  44.22371  1.000 16.06659  ? 147 GLU E C   1 
ATOM   3213 O  O   . GLU C 1 111 ? -5.13116  29.91338  43.76987  1.000 15.76382  ? 147 GLU E O   1 
ATOM   3214 C  CB  . GLU C 1 111 ? -4.17620  29.04847  46.26649  1.000 15.47219  ? 147 GLU E CB  1 
ATOM   3215 C  CG  . GLU C 1 111 ? -3.76026  28.87287  47.72989  1.000 16.32494  ? 147 GLU E CG  1 
ATOM   3216 C  CD  . GLU C 1 111 ? -3.84542  27.45125  48.17833  1.000 17.38314  ? 147 GLU E CD  1 
ATOM   3217 O  OE1 . GLU C 1 111 ? -4.91962  26.82836  48.00196  1.000 17.50821  ? 147 GLU E OE1 1 
ATOM   3218 O  OE2 . GLU C 1 111 ? -2.83849  26.96267  48.73616  1.000 17.83363  ? 147 GLU E OE2 1 
ATOM   3219 N  N   . GLN C 1 112 ? -3.32260  31.22592  43.47299  1.000 14.48784  ? 148 GLN E N   1 
ATOM   3220 C  CA  . GLN C 1 112 ? -3.65217  31.56344  42.09633  1.000 11.88897  ? 148 GLN E CA  1 
ATOM   3221 C  C   . GLN C 1 112 ? -2.96536  30.68189  41.06048  1.000 15.15636  ? 148 GLN E C   1 
ATOM   3222 O  O   . GLN C 1 112 ? -3.29325  30.79650  39.88370  1.000 15.96777  ? 148 GLN E O   1 
ATOM   3223 C  CB  . GLN C 1 112 ? -3.29811  33.02942  41.82804  1.000 15.19823  ? 148 GLN E CB  1 
ATOM   3224 C  CG  . GLN C 1 112 ? -4.24105  33.97346  42.57160  1.000 19.63313  ? 148 GLN E CG  1 
ATOM   3225 C  CD  . GLN C 1 112 ? -3.82411  35.41758  42.42192  1.000 32.94843  ? 148 GLN E CD  1 
ATOM   3226 O  OE1 . GLN C 1 112 ? -2.63762  35.73964  42.47988  1.000 33.26945  ? 148 GLN E OE1 1 
ATOM   3227 N  NE2 . GLN C 1 112 ? -4.79281  36.29275  42.21053  1.000 33.82006  ? 148 GLN E NE2 1 
ATOM   3228 N  N   . CYS C 1 113 ? -2.02115  29.83350  41.45918  1.000 13.06444  ? 149 CYS E N   1 
ATOM   3229 C  CA  . CYS C 1 113 ? -1.22382  29.04676  40.52200  1.000 12.61007  ? 149 CYS E CA  1 
ATOM   3230 C  C   . CYS C 1 113 ? -1.48418  27.55732  40.72352  1.000 15.00254  ? 149 CYS E C   1 
ATOM   3231 O  O   . CYS C 1 113 ? -1.83433  27.11718  41.82285  1.000 18.35968  ? 149 CYS E O   1 
ATOM   3232 C  CB  . CYS C 1 113 ? 0.27417   29.37000  40.70948  1.000 14.51251  ? 149 CYS E CB  1 
ATOM   3233 S  SG  . CYS C 1 113 ? 0.64583   31.02842  40.10984  1.000 17.39410  ? 149 CYS E SG  1 
ATOM   3234 N  N   . VAL C 1 114 ? -1.31267  26.75736  39.67074  1.000 12.38367  ? 150 VAL E N   1 
ATOM   3235 C  CA  . VAL C 1 114 ? -1.75161  25.36017  39.70650  1.000 13.97380  ? 150 VAL E CA  1 
ATOM   3236 C  C   . VAL C 1 114 ? -0.55480  24.41620  39.65146  1.000 13.38903  ? 150 VAL E C   1 
ATOM   3237 O  O   . VAL C 1 114 ? 0.30326   24.53328  38.76353  1.000 13.80503  ? 150 VAL E O   1 
ATOM   3238 C  CB  . VAL C 1 114 ? -2.72175  25.04844  38.55718  1.000 12.92779  ? 150 VAL E CB  1 
ATOM   3239 C  CG1 . VAL C 1 114 ? -3.17072  23.56759  38.62995  1.000 14.96853  ? 150 VAL E CG1 1 
ATOM   3240 C  CG2 . VAL C 1 114 ? -3.93395  25.97387  38.65055  1.000 14.01567  ? 150 VAL E CG2 1 
ATOM   3241 N  N   . GLU C 1 115 ? -0.51867  23.46487  40.58453  1.000 13.07796  ? 151 GLU E N   1 
ATOM   3242 C  CA  . GLU C 1 115 ? 0.46325   22.38667  40.57714  1.000 12.28876  ? 151 GLU E CA  1 
ATOM   3243 C  C   . GLU C 1 115 ? -0.27394  21.07408  40.37957  1.000 14.62608  ? 151 GLU E C   1 
ATOM   3244 O  O   . GLU C 1 115 ? -1.45850  20.95120  40.72870  1.000 15.22029  ? 151 GLU E O   1 
ATOM   3245 C  CB  . GLU C 1 115 ? 1.26489   22.28544  41.89339  1.000 12.60249  ? 151 GLU E CB  1 
ATOM   3246 C  CG  . GLU C 1 115 ? 0.34722   22.14577  43.11038  1.000 14.37398  ? 151 GLU E CG  1 
ATOM   3247 C  CD  . GLU C 1 115 ? 1.08440   21.91251  44.41505  1.000 18.37632  ? 151 GLU E CD  1 
ATOM   3248 O  OE1 . GLU C 1 115 ? 2.34416   21.91198  44.44211  1.000 16.78270  ? 151 GLU E OE1 1 
ATOM   3249 O  OE2 . GLU C 1 115 ? 0.38305   21.74536  45.44057  1.000 18.99735  ? 151 GLU E OE2 1 
ATOM   3250 N  N   . GLN C 1 116 ? 0.42324   20.11213  39.77206  1.000 12.04231  ? 152 GLN E N   1 
ATOM   3251 C  CA  . GLN C 1 116 ? 0.01863   18.71434  39.85504  1.000 14.37353  ? 152 GLN E CA  1 
ATOM   3252 C  C   . GLN C 1 116 ? 0.62549   18.16835  41.13697  1.000 18.39039  ? 152 GLN E C   1 
ATOM   3253 O  O   . GLN C 1 116 ? 1.84674   18.20675  41.29789  1.000 15.58352  ? 152 GLN E O   1 
ATOM   3254 C  CB  . GLN C 1 116 ? 0.51901   17.93253  38.63801  1.000 14.41023  ? 152 GLN E CB  1 
ATOM   3255 C  CG  . GLN C 1 116 ? 0.47570   16.40129  38.79937  1.000 13.99823  ? 152 GLN E CG  1 
ATOM   3256 C  CD  . GLN C 1 116 ? -0.95936  15.90335  38.73590  1.000 20.42427  ? 152 GLN E CD  1 
ATOM   3257 O  OE1 . GLN C 1 116 ? -1.84685  16.61741  38.24745  1.000 17.66618  ? 152 GLN E OE1 1 
ATOM   3258 N  NE2 . GLN C 1 116 ? -1.20265  14.70011  39.22879  1.000 19.13411  ? 152 GLN E NE2 1 
ATOM   3259 N  N   . ILE C 1 117 ? -0.20430  17.71594  42.07320  1.000 15.96662  ? 153 ILE E N   1 
ATOM   3260 C  CA  . ILE C 1 117 ? 0.33072   17.24396  43.34647  1.000 20.46266  ? 153 ILE E CA  1 
ATOM   3261 C  C   . ILE C 1 117 ? 0.44204   15.73028  43.26561  1.000 31.77830  ? 153 ILE E C   1 
ATOM   3262 O  O   . ILE C 1 117 ? -0.41456  15.05629  42.67539  1.000 26.99486  ? 153 ILE E O   1 
ATOM   3263 C  CB  . ILE C 1 117 ? -0.52590  17.70507  44.54474  1.000 25.69910  ? 153 ILE E CB  1 
ATOM   3264 C  CG1 . ILE C 1 117 ? 0.13227   17.30792  45.86920  1.000 43.54469  ? 153 ILE E CG1 1 
ATOM   3265 C  CG2 . ILE C 1 117 ? -1.91541  17.09729  44.50182  1.000 31.95030  ? 153 ILE E CG2 1 
ATOM   3266 C  CD1 . ILE C 1 117 ? 1.55338   17.80664  46.03463  1.000 49.16008  ? 153 ILE E CD1 1 
ATOM   3267 N  N   . ASP C 1 118 ? 1.52667   15.19053  43.80806  1.000 26.87802  ? 154 ASP E N   1 
ATOM   3268 C  CA  . ASP C 1 118 ? 1.69214   13.74396  43.87287  1.000 27.90942  ? 154 ASP E CA  1 
ATOM   3269 C  C   . ASP C 1 118 ? 1.96081   13.39373  45.32535  1.000 34.49447  ? 154 ASP E C   1 
ATOM   3270 O  O   . ASP C 1 118 ? 3.06235   13.61726  45.83355  1.000 38.25587  ? 154 ASP E O   1 
ATOM   3271 C  CB  . ASP C 1 118 ? 2.82070   13.23832  42.99497  1.000 28.68988  ? 154 ASP E CB  1 
ATOM   3272 C  CG  . ASP C 1 118 ? 2.74638   11.73763  42.78952  1.000 34.06620  ? 154 ASP E CG  1 
ATOM   3273 O  OD1 . ASP C 1 118 ? 1.76904   11.26331  42.15770  1.000 35.86417  ? 154 ASP E OD1 1 
ATOM   3274 O  OD2 . ASP C 1 118 ? 3.60467   11.02957  43.35549  1.000 35.42972  ? 154 ASP E OD2 1 
ATOM   3275 N  N   . ARG C 1 119 ? 0.95329   12.83849  45.97668  1.000 30.78844  ? 155 ARG E N   1 
ATOM   3276 C  CA  . ARG C 1 119 ? 1.07931   12.39836  47.34964  1.000 52.21070  ? 155 ARG E CA  1 
ATOM   3277 C  C   . ARG C 1 119 ? 0.23701   11.14208  47.49411  1.000 50.97131  ? 155 ARG E C   1 
ATOM   3278 O  O   . ARG C 1 119 ? -0.64090  10.86481  46.67270  1.000 49.10942  ? 155 ARG E O   1 
ATOM   3279 C  CB  . ARG C 1 119 ? 0.64161   13.51610  48.29947  1.000 53.18855  ? 155 ARG E CB  1 
ATOM   3280 C  CG  . ARG C 1 119 ? 1.80171   14.34748  48.81986  1.000 57.55714  ? 155 ARG E CG  1 
ATOM   3281 C  CD  . ARG C 1 119 ? 1.30418   15.66362  49.39299  1.000 71.27376  ? 155 ARG E CD  1 
ATOM   3282 N  NE  . ARG C 1 119 ? 1.21239   15.64817  50.84563  1.000 83.39446  ? 155 ARG E NE  1 
ATOM   3283 C  CZ  . ARG C 1 119 ? 0.10371   15.91412  51.52108  1.000 86.84474  ? 155 ARG E CZ  1 
ATOM   3284 N  NH1 . ARG C 1 119 ? -1.02842  16.20764  50.90133  1.000 82.03587  ? 155 ARG E NH1 1 
ATOM   3285 N  NH2 . ARG C 1 119 ? 0.12990   15.87910  52.85047  1.000 92.89015  ? 155 ARG E NH2 1 
ATOM   3286 N  N   . GLU C 1 120 ? 0.53194   10.35160  48.51449  1.000 56.87246  ? 156 GLU E N   1 
ATOM   3287 C  CA  . GLU C 1 120 ? -0.32408  9.20937   48.78038  1.000 58.89822  ? 156 GLU E CA  1 
ATOM   3288 C  C   . GLU C 1 120 ? -1.68192  9.73139   49.23148  1.000 59.82071  ? 156 GLU E C   1 
ATOM   3289 O  O   . GLU C 1 120 ? -1.75694  10.62205  50.08510  1.000 58.93976  ? 156 GLU E O   1 
ATOM   3290 C  CB  . GLU C 1 120 ? 0.30385   8.30436   49.83638  1.000 65.30128  ? 156 GLU E CB  1 
ATOM   3291 C  CG  . GLU C 1 120 ? 1.33239   7.32933   49.27354  1.000 63.74785  ? 156 GLU E CG  1 
ATOM   3292 C  CD  . GLU C 1 120 ? 0.71603   6.19914   48.45887  1.000 68.22626  ? 156 GLU E CD  1 
ATOM   3293 O  OE1 . GLU C 1 120 ? -0.46748  5.86187   48.68694  1.000 64.78762  ? 156 GLU E OE1 1 
ATOM   3294 O  OE2 . GLU C 1 120 ? 1.42770   5.63701   47.59696  1.000 65.56949  ? 156 GLU E OE2 1 
ATOM   3295 N  N   . ASP C 1 121 ? -2.74634  9.22310   48.60775  1.000 65.02044  ? 157 ASP E N   1 
ATOM   3296 C  CA  . ASP C 1 121 ? -4.15522  9.53923   48.82970  1.000 68.00057  ? 157 ASP E CA  1 
ATOM   3297 C  C   . ASP C 1 121 ? -4.59478  10.81722  48.10413  1.000 68.37255  ? 157 ASP E C   1 
ATOM   3298 O  O   . ASP C 1 121 ? -5.79171  11.10768  48.08422  1.000 65.17610  ? 157 ASP E O   1 
ATOM   3299 C  CB  . ASP C 1 121 ? -4.52351  9.67565   50.32253  1.000 76.34943  ? 157 ASP E CB  1 
ATOM   3300 C  CG  . ASP C 1 121 ? -4.53523  8.34353   51.05242  1.000 84.80025  ? 157 ASP E CG  1 
ATOM   3301 O  OD1 . ASP C 1 121 ? -5.45731  7.53369   50.81145  1.000 81.98572  ? 157 ASP E OD1 1 
ATOM   3302 O  OD2 . ASP C 1 121 ? -3.62007  8.11231   51.87427  1.000 88.77171  ? 157 ASP E OD2 1 
ATOM   3303 N  N   . LYS C 1 122 ? -3.68060  11.57924  47.49692  1.000 60.76617  ? 158 LYS E N   1 
ATOM   3304 C  CA  . LYS C 1 122 ? -3.97012  12.91678  46.96646  1.000 56.82297  ? 158 LYS E CA  1 
ATOM   3305 C  C   . LYS C 1 122 ? -3.16861  13.08484  45.67552  1.000 43.50343  ? 158 LYS E C   1 
ATOM   3306 O  O   . LYS C 1 122 ? -1.95321  13.29788  45.72996  1.000 51.10439  ? 158 LYS E O   1 
ATOM   3307 C  CB  . LYS C 1 122 ? -3.59461  13.98672  47.99389  1.000 53.96944  ? 158 LYS E CB  1 
ATOM   3308 C  CG  . LYS C 1 122 ? -4.15387  15.40949  47.79371  1.000 55.93527  ? 158 LYS E CG  1 
ATOM   3309 C  CD  . LYS C 1 122 ? -5.64227  15.47190  47.50080  1.000 54.56718  ? 158 LYS E CD  1 
ATOM   3310 C  CE  . LYS C 1 122 ? -6.28008  16.74920  48.07278  1.000 47.82695  ? 158 LYS E CE  1 
ATOM   3311 N  NZ  . LYS C 1 122 ? -5.57984  18.01321  47.64104  1.000 45.27396  ? 158 LYS E NZ  1 
ATOM   3312 N  N   . LYS C 1 123 ? -3.83671  12.97755  44.52218  1.000 40.74655  ? 159 LYS E N   1 
ATOM   3313 C  CA  . LYS C 1 123 ? -3.20485  13.20816  43.22643  1.000 33.10027  ? 159 LYS E CA  1 
ATOM   3314 C  C   . LYS C 1 123 ? -4.10025  14.07155  42.34126  1.000 29.57019  ? 159 LYS E C   1 
ATOM   3315 O  O   . LYS C 1 123 ? -5.32824  13.94716  42.35112  1.000 28.79815  ? 159 LYS E O   1 
ATOM   3316 C  CB  . LYS C 1 123 ? -2.90180  11.89158  42.48342  1.000 37.40871  ? 159 LYS E CB  1 
ATOM   3317 C  CG  . LYS C 1 123 ? -1.79212  11.01837  43.07132  1.000 48.93746  ? 159 LYS E CG  1 
ATOM   3318 C  CD  . LYS C 1 123 ? -2.36992  9.83032   43.84032  1.000 62.57685  ? 159 LYS E CD  1 
ATOM   3319 C  CE  . LYS C 1 123 ? -1.31382  8.76190   44.13397  1.000 55.23572  ? 159 LYS E CE  1 
ATOM   3320 N  NZ  . LYS C 1 123 ? 0.07230   9.30528   44.22202  1.000 55.15775  ? 159 LYS E NZ  1 
ATOM   3321 N  N   . GLY C 1 124 ? -3.47893  14.91857  41.53833  1.000 22.03602  ? 160 GLY E N   1 
ATOM   3322 C  CA  . GLY C 1 124 ? -4.21422  15.77399  40.62305  1.000 20.06637  ? 160 GLY E CA  1 
ATOM   3323 C  C   . GLY C 1 124 ? -3.86974  17.22535  40.87311  1.000 17.35817  ? 160 GLY E C   1 
ATOM   3324 O  O   . GLY C 1 124 ? -2.92842  17.54910  41.59567  1.000 21.28814  ? 160 GLY E O   1 
ATOM   3325 N  N   . TRP C 1 125 ? -4.67107  18.11639  40.30127  1.000 16.65267  ? 161 TRP E N   1 
ATOM   3326 C  CA  . TRP C 1 125 ? -4.27633  19.51749  40.33804  1.000 13.97731  ? 161 TRP E CA  1 
ATOM   3327 C  C   . TRP C 1 125 ? -4.62020  20.12575  41.68489  1.000 14.10398  ? 161 TRP E C   1 
ATOM   3328 O  O   . TRP C 1 125 ? -5.61694  19.76299  42.32515  1.000 15.58609  ? 161 TRP E O   1 
ATOM   3329 C  CB  . TRP C 1 125 ? -4.99119  20.34172  39.27439  1.000 13.96346  ? 161 TRP E CB  1 
ATOM   3330 C  CG  . TRP C 1 125 ? -4.81333  19.89186  37.86116  1.000 12.77652  ? 161 TRP E CG  1 
ATOM   3331 C  CD1 . TRP C 1 125 ? -3.92246  18.98022  37.36893  1.000 14.78777  ? 161 TRP E CD1 1 
ATOM   3332 C  CD2 . TRP C 1 125 ? -5.57721  20.36404  36.75457  1.000 16.22365  ? 161 TRP E CD2 1 
ATOM   3333 N  NE1 . TRP C 1 125 ? -4.09406  18.85441  35.99216  1.000 13.67830  ? 161 TRP E NE1 1 
ATOM   3334 C  CE2 . TRP C 1 125 ? -5.09947  19.71018  35.60072  1.000 15.32541  ? 161 TRP E CE2 1 
ATOM   3335 C  CE3 . TRP C 1 125 ? -6.61110  21.31171  36.62866  1.000 17.74405  ? 161 TRP E CE3 1 
ATOM   3336 C  CZ2 . TRP C 1 125 ? -5.63457  19.95500  34.33373  1.000 17.30450  ? 161 TRP E CZ2 1 
ATOM   3337 C  CZ3 . TRP C 1 125 ? -7.14230  21.55262  35.38579  1.000 16.18235  ? 161 TRP E CZ3 1 
ATOM   3338 C  CH2 . TRP C 1 125 ? -6.65591  20.87814  34.24509  1.000 16.30047  ? 161 TRP E CH2 1 
ATOM   3339 N  N   . ASN C 1 126 ? -3.83529  21.12788  42.07117  1.000 12.57792  ? 162 ASN E N   1 
ATOM   3340 C  CA  . ASN C 1 126 ? -4.09767  21.85017  43.30323  1.000 13.04115  ? 162 ASN E CA  1 
ATOM   3341 C  C   . ASN C 1 126 ? -3.77305  23.31977  43.05167  1.000 14.01058  ? 162 ASN E C   1 
ATOM   3342 O  O   . ASN C 1 126 ? -2.75161  23.62670  42.42348  1.000 14.46678  ? 162 ASN E O   1 
ATOM   3343 C  CB  . ASN C 1 126 ? -3.22782  21.30810  44.45405  1.000 14.49748  ? 162 ASN E CB  1 
ATOM   3344 C  CG  . ASN C 1 126 ? -3.30265  22.19468  45.68242  1.000 16.96639  ? 162 ASN E CG  1 
ATOM   3345 O  OD1 . ASN C 1 126 ? -4.40800  22.52884  46.12208  1.000 16.84154  ? 162 ASN E OD1 1 
ATOM   3346 N  ND2 . ASN C 1 126 ? -2.14127  22.57616  46.25915  1.000 15.45869  ? 162 ASN E ND2 1 
ATOM   3347 N  N   . ASP C 1 127 ? -4.63175  24.23444  43.51035  1.000 15.22057  ? 163 ASP E N   1 
ATOM   3348 C  CA  . ASP C 1 127 ? -4.21320  25.63069  43.54734  1.000 13.42146  ? 163 ASP E CA  1 
ATOM   3349 C  C   . ASP C 1 127 ? -3.28361  25.87100  44.73452  1.000 14.04630  ? 163 ASP E C   1 
ATOM   3350 O  O   . ASP C 1 127 ? -3.51570  25.38273  45.84957  1.000 13.81524  ? 163 ASP E O   1 
ATOM   3351 C  CB  . ASP C 1 127 ? -5.41424  26.60428  43.57441  1.000 12.89697  ? 163 ASP E CB  1 
ATOM   3352 C  CG  . ASP C 1 127 ? -6.34966  26.40070  44.77230  1.000 15.98200  ? 163 ASP E CG  1 
ATOM   3353 O  OD1 . ASP C 1 127 ? -6.41220  25.29857  45.37151  1.000 14.63726  ? 163 ASP E OD1 1 
ATOM   3354 O  OD2 . ASP C 1 127 ? -7.02990  27.37886  45.11381  1.000 14.88737  ? 163 ASP E OD2 1 
ATOM   3355 N  N   . LEU C 1 128 ? -2.21576  26.62484  44.47329  1.000 14.26998  ? 164 LEU E N   1 
ATOM   3356 C  CA  . LEU C 1 128 ? -1.18250  26.87890  45.46605  1.000 15.54937  ? 164 LEU E CA  1 
ATOM   3357 C  C   . LEU C 1 128 ? -0.74027  28.33494  45.39692  1.000 14.52105  ? 164 LEU E C   1 
ATOM   3358 O  O   . LEU C 1 128 ? -0.85118  28.98957  44.36044  1.000 14.78098  ? 164 LEU E O   1 
ATOM   3359 C  CB  . LEU C 1 128 ? 0.02134   25.94236  45.23988  1.000 14.31390  ? 164 LEU E CB  1 
ATOM   3360 C  CG  . LEU C 1 128 ? 1.03457   25.89433  46.38023  1.000 15.70175  ? 164 LEU E CG  1 
ATOM   3361 C  CD1 . LEU C 1 128 ? 0.36640   25.35856  47.62884  1.000 16.05858  ? 164 LEU E CD1 1 
ATOM   3362 C  CD2 . LEU C 1 128 ? 2.19924   24.97024  45.95253  1.000 15.86327  ? 164 LEU E CD2 1 
ATOM   3363 N  N   . VAL C 1 129 ? -0.23653  28.84401  46.52460  1.000 13.86163  ? 165 VAL E N   1 
ATOM   3364 C  CA  . VAL C 1 129 ? 0.41152   30.15678  46.53466  1.000 14.07316  ? 165 VAL E CA  1 
ATOM   3365 C  C   . VAL C 1 129 ? 1.51938   30.22512  45.48572  1.000 13.73159  ? 165 VAL E C   1 
ATOM   3366 O  O   . VAL C 1 129 ? 2.43487   29.38932  45.47725  1.000 14.45900  ? 165 VAL E O   1 
ATOM   3367 C  CB  . VAL C 1 129 ? 0.97681   30.41520  47.93924  1.000 15.66500  ? 165 VAL E CB  1 
ATOM   3368 C  CG1 . VAL C 1 129 ? 1.74559   31.72811  47.95328  1.000 19.28304  ? 165 VAL E CG1 1 
ATOM   3369 C  CG2 . VAL C 1 129 ? -0.16742  30.39903  48.96002  1.000 18.36266  ? 165 VAL E CG2 1 
ATOM   3370 N  N   . CYS C 1 130 ? 1.45344   31.24044  44.60246  1.000 16.41223  ? 166 CYS E N   1 
ATOM   3371 C  CA  . CYS C 1 130 ? 2.34514   31.27377  43.44041  1.000 14.58083  ? 166 CYS E CA  1 
ATOM   3372 C  C   . CYS C 1 130 ? 3.79690   31.41235  43.84079  1.000 15.82104  ? 166 CYS E C   1 
ATOM   3373 O  O   . CYS C 1 130 ? 4.69123   31.00058  43.09040  1.000 17.41420  ? 166 CYS E O   1 
ATOM   3374 C  CB  . CYS C 1 130 ? 1.99461   32.44313  42.51351  1.000 20.19762  ? 166 CYS E CB  1 
ATOM   3375 S  SG  . CYS C 1 130 ? 0.36674   32.28187  41.72226  1.000 21.43285  ? 166 CYS E SG  1 
ATOM   3376 N  N   . GLU C 1 131 ? 4.04317   32.02809  44.99082  1.000 16.80825  ? 167 GLU E N   1 
ATOM   3377 C  CA  . GLU C 1 131 ? 5.39784   32.28271  45.46034  1.000 21.08888  ? 167 GLU E CA  1 
ATOM   3378 C  C   . GLU C 1 131 ? 6.02619   31.06364  46.11630  1.000 16.68955  ? 167 GLU E C   1 
ATOM   3379 O  O   . GLU C 1 131 ? 7.22127   31.10704  46.45000  1.000 18.19074  ? 167 GLU E O   1 
ATOM   3380 C  CB  . GLU C 1 131 ? 5.37712   33.46756  46.44049  1.000 24.22562  ? 167 GLU E CB  1 
ATOM   3381 C  CG  . GLU C 1 131 ? 5.09854   34.80705  45.75704  1.000 26.32253  ? 167 GLU E CG  1 
ATOM   3382 C  CD  . GLU C 1 131 ? 3.65596   34.96658  45.24978  1.000 46.26525  ? 167 GLU E CD  1 
ATOM   3383 O  OE1 . GLU C 1 131 ? 2.69247   34.41091  45.86681  1.000 34.21057  ? 167 GLU E OE1 1 
ATOM   3384 O  OE2 . GLU C 1 131 ? 3.49277   35.63707  44.20261  1.000 40.64452  ? 167 GLU E OE2 1 
ATOM   3385 N  N   . PHE C 1 132 ? 5.26793   29.98086  46.30372  1.000 15.38509  ? 168 PHE E N   1 
ATOM   3386 C  CA  . PHE C 1 132 ? 5.85386   28.72399  46.77068  1.000 16.26462  ? 168 PHE E CA  1 
ATOM   3387 C  C   . PHE C 1 132 ? 6.68541   28.08766  45.64363  1.000 13.98227  ? 168 PHE E C   1 
ATOM   3388 O  O   . PHE C 1 132 ? 6.56931   28.45760  44.47320  1.000 16.60847  ? 168 PHE E O   1 
ATOM   3389 C  CB  . PHE C 1 132 ? 4.76189   27.74845  47.22022  1.000 16.41276  ? 168 PHE E CB  1 
ATOM   3390 C  CG  . PHE C 1 132 ? 4.10145   28.12827  48.52851  1.000 16.58258  ? 168 PHE E CG  1 
ATOM   3391 C  CD1 . PHE C 1 132 ? 4.39265   29.34759  49.14517  1.000 20.12768  ? 168 PHE E CD1 1 
ATOM   3392 C  CD2 . PHE C 1 132 ? 3.18309   27.28181  49.11383  1.000 22.48617  ? 168 PHE E CD2 1 
ATOM   3393 C  CE1 . PHE C 1 132 ? 3.76533   29.71052  50.34315  1.000 23.76461  ? 168 PHE E CE1 1 
ATOM   3394 C  CE2 . PHE C 1 132 ? 2.55672   27.62591  50.30170  1.000 24.48439  ? 168 PHE E CE2 1 
ATOM   3395 C  CZ  . PHE C 1 132 ? 2.85195   28.84789  50.91621  1.000 24.34750  ? 168 PHE E CZ  1 
ATOM   3396 N  N   . SER C 1 133 ? 7.54322   27.14178  46.00142  1.000 16.68370  ? 169 SER E N   1 
ATOM   3397 C  CA  . SER C 1 133 ? 8.43596   26.54980  45.01163  1.000 14.90673  ? 169 SER E CA  1 
ATOM   3398 C  C   . SER C 1 133 ? 8.12987   25.08216  44.73418  1.000 15.57639  ? 169 SER E C   1 
ATOM   3399 O  O   . SER C 1 133 ? 7.82282   24.30795  45.64795  1.000 18.97571  ? 169 SER E O   1 
ATOM   3400 C  CB  . SER C 1 133 ? 9.89326   26.71735  45.44731  1.000 19.18966  ? 169 SER E CB  1 
ATOM   3401 O  OG  . SER C 1 133 ? 10.26628  28.05962  45.14419  1.000 19.16523  ? 169 SER E OG  1 
ATOM   3402 N  N   . ASN C 1 134 ? 8.27826   24.70501  43.46328  1.000 13.43932  ? 170 ASN E N   1 
ATOM   3403 C  CA  . ASN C 1 134 ? 8.04638   23.34755  42.98499  1.000 12.80394  ? 170 ASN E CA  1 
ATOM   3404 C  C   . ASN C 1 134 ? 8.98260   23.09454  41.80577  1.000 14.91272  ? 170 ASN E C   1 
ATOM   3405 O  O   . ASN C 1 134 ? 9.37390   24.03277  41.09454  1.000 13.54519  ? 170 ASN E O   1 
ATOM   3406 C  CB  . ASN C 1 134 ? 6.61283   23.16370  42.46825  1.000 12.41048  ? 170 ASN E CB  1 
ATOM   3407 C  CG  . ASN C 1 134 ? 5.62182   22.80714  43.55848  1.000 17.37808  ? 170 ASN E CG  1 
ATOM   3408 O  OD1 . ASN C 1 134 ? 5.89033   21.96593  44.40479  1.000 17.05253  ? 170 ASN E OD1 1 
ATOM   3409 N  ND2 . ASN C 1 134 ? 4.43444   23.41332  43.49261  1.000 17.97806  ? 170 ASN E ND2 1 
ATOM   3410 N  N   . PHE C 1 135 ? 9.28555   21.81764  41.55294  1.000 12.20659  ? 171 PHE E N   1 
ATOM   3411 C  CA  . PHE C 1 135 ? 9.79770   21.47891  40.22995  1.000 13.77958  ? 171 PHE E CA  1 
ATOM   3412 C  C   . PHE C 1 135 ? 8.75354   21.88963  39.19887  1.000 13.65443  ? 171 PHE E C   1 
ATOM   3413 O  O   . PHE C 1 135 ? 7.58992   22.09260  39.53259  1.000 13.29789  ? 171 PHE E O   1 
ATOM   3414 C  CB  . PHE C 1 135 ? 10.06935  19.98505  40.12810  1.000 13.37826  ? 171 PHE E CB  1 
ATOM   3415 C  CG  . PHE C 1 135 ? 11.18138  19.51108  41.03742  1.000 12.82379  ? 171 PHE E CG  1 
ATOM   3416 C  CD1 . PHE C 1 135 ? 12.48306  19.95391  40.84625  1.000 14.99278  ? 171 PHE E CD1 1 
ATOM   3417 C  CD2 . PHE C 1 135 ? 10.91309  18.61182  42.05781  1.000 18.55745  ? 171 PHE E CD2 1 
ATOM   3418 C  CE1 . PHE C 1 135 ? 13.51351  19.50305  41.67413  1.000 17.50884  ? 171 PHE E CE1 1 
ATOM   3419 C  CE2 . PHE C 1 135 ? 11.94257  18.14957  42.88917  1.000 19.24260  ? 171 PHE E CE2 1 
ATOM   3420 C  CZ  . PHE C 1 135 ? 13.24062  18.60351  42.68849  1.000 17.18372  ? 171 PHE E CZ  1 
ATOM   3421 N  N   . TYR C 1 136 ? 9.16450   22.03662  37.93642  1.000 11.40378  ? 172 TYR E N   1 
ATOM   3422 C  CA  . TYR C 1 136 ? 8.21126   22.51447  36.94460  1.000 13.91570  ? 172 TYR E CA  1 
ATOM   3423 C  C   . TYR C 1 136 ? 8.42913   21.77675  35.63435  1.000 14.03461  ? 172 TYR E C   1 
ATOM   3424 O  O   . TYR C 1 136 ? 9.50115   21.21595  35.39515  1.000 15.44160  ? 172 TYR E O   1 
ATOM   3425 C  CB  . TYR C 1 136 ? 8.34549   24.02745  36.73123  1.000 15.30315  ? 172 TYR E CB  1 
ATOM   3426 C  CG  . TYR C 1 136 ? 9.76194   24.51977  36.46740  1.000 15.74587  ? 172 TYR E CG  1 
ATOM   3427 C  CD1 . TYR C 1 136 ? 10.60508  24.84049  37.52533  1.000 14.54119  ? 172 TYR E CD1 1 
ATOM   3428 C  CD2 . TYR C 1 136 ? 10.22325  24.71257  35.16189  1.000 15.87381  ? 172 TYR E CD2 1 
ATOM   3429 C  CE1 . TYR C 1 136 ? 11.88850  25.33032  37.30269  1.000 15.89580  ? 172 TYR E CE1 1 
ATOM   3430 C  CE2 . TYR C 1 136 ? 11.52037  25.19286  34.92192  1.000 16.51224  ? 172 TYR E CE2 1 
ATOM   3431 C  CZ  . TYR C 1 136 ? 12.33349  25.50689  36.00333  1.000 20.08124  ? 172 TYR E CZ  1 
ATOM   3432 O  OH  . TYR C 1 136 ? 13.60428  25.98927  35.77998  1.000 20.24517  ? 172 TYR E OH  1 
ATOM   3433 N  N   . MET C 1 137 ? 7.38452   21.74121  34.80323  1.000 14.21923  ? 173 MET E N   1 
ATOM   3434 C  CA  A MET C 1 137 ? 7.42448   21.07715  33.50650  0.744 13.62621  ? 173 MET E CA  1 
ATOM   3435 C  CA  B MET C 1 137 ? 7.48168   21.09085  33.50646  0.256 13.54347  ? 173 MET E CA  1 
ATOM   3436 C  C   . MET C 1 137 ? 7.15975   22.08541  32.40401  1.000 13.70966  ? 173 MET E C   1 
ATOM   3437 O  O   . MET C 1 137 ? 6.11442   22.74745  32.42378  1.000 15.13423  ? 173 MET E O   1 
ATOM   3438 C  CB  A MET C 1 137 ? 6.36841   19.97140  33.43113  0.744 17.27692  ? 173 MET E CB  1 
ATOM   3439 C  CB  B MET C 1 137 ? 6.57476   19.85633  33.40278  0.256 17.13155  ? 173 MET E CB  1 
ATOM   3440 C  CG  A MET C 1 137 ? 6.36017   19.24086  32.08872  0.744 15.01963  ? 173 MET E CG  1 
ATOM   3441 C  CG  B MET C 1 137 ? 6.71223   19.13694  32.04581  0.256 15.10684  ? 173 MET E CG  1 
ATOM   3442 S  SD  A MET C 1 137 ? 5.05464   18.00875  32.07330  0.744 20.64011  ? 173 MET E SD  1 
ATOM   3443 S  SD  B MET C 1 137 ? 6.18961   17.40583  32.02341  0.256 25.03651  ? 173 MET E SD  1 
ATOM   3444 C  CE  A MET C 1 137 ? 6.00614   16.52432  32.36729  0.744 20.85014  ? 173 MET E CE  1 
ATOM   3445 C  CE  B MET C 1 137 ? 4.46067   17.57703  31.58097  0.256 21.06917  ? 173 MET E CE  1 
ATOM   3446 N  N   . CYS C 1 138 ? 8.06716   22.17004  31.43816  1.000 13.05733  ? 174 CYS E N   1 
ATOM   3447 C  CA  . CYS C 1 138 ? 7.83973   22.98868  30.26237  1.000 12.55199  ? 174 CYS E CA  1 
ATOM   3448 C  C   . CYS C 1 138 ? 7.27801   22.09923  29.16467  1.000 15.32151  ? 174 CYS E C   1 
ATOM   3449 O  O   . CYS C 1 138 ? 7.56258   20.90051  29.10003  1.000 14.93331  ? 174 CYS E O   1 
ATOM   3450 C  CB  . CYS C 1 138 ? 9.14432   23.60432  29.76130  1.000 14.33246  ? 174 CYS E CB  1 
ATOM   3451 S  SG  . CYS C 1 138 ? 10.05799  24.59601  30.93326  1.000 19.05164  ? 174 CYS E SG  1 
ATOM   3452 N  N   . GLU C 1 139 ? 6.52897   22.72071  28.26273  1.000 14.60802  ? 175 GLU E N   1 
ATOM   3453 C  CA  . GLU C 1 139 ? 6.05533   22.05400  27.06219  1.000 14.70742  ? 175 GLU E CA  1 
ATOM   3454 C  C   . GLU C 1 139 ? 6.25231   22.99034  25.87457  1.000 18.11459  ? 175 GLU E C   1 
ATOM   3455 O  O   . GLU C 1 139 ? 5.93661   24.17847  25.95015  1.000 18.13337  ? 175 GLU E O   1 
ATOM   3456 C  CB  . GLU C 1 139 ? 4.57057   21.65940  27.19531  1.000 14.89134  ? 175 GLU E CB  1 
ATOM   3457 C  CG  . GLU C 1 139 ? 4.03937   20.91553  25.96100  1.000 18.26658  ? 175 GLU E CG  1 
ATOM   3458 C  CD  . GLU C 1 139 ? 2.54015   20.67872  25.99651  1.000 19.88454  ? 175 GLU E CD  1 
ATOM   3459 O  OE1 . GLU C 1 139 ? 1.86977   21.16378  26.92561  1.000 16.10611  ? 175 GLU E OE1 1 
ATOM   3460 O  OE2 . GLU C 1 139 ? 2.02247   20.00358  25.07567  1.000 16.75380  ? 175 GLU E OE2 1 
ATOM   3461 N  N   . LYS C 1 140 ? 6.76314   22.43966  24.77723  1.000 17.63325  ? 176 LYS E N   1 
ATOM   3462 C  CA  . LYS C 1 140 ? 6.91777   23.16331  23.52207  1.000 19.40948  ? 176 LYS E CA  1 
ATOM   3463 C  C   . LYS C 1 140 ? 6.25092   22.33439  22.43270  1.000 20.61718  ? 176 LYS E C   1 
ATOM   3464 O  O   . LYS C 1 140 ? 6.58088   21.15968  22.26340  1.000 17.45696  ? 176 LYS E O   1 
ATOM   3465 C  CB  . LYS C 1 140 ? 8.41521   23.37605  23.23980  1.000 25.18497  ? 176 LYS E CB  1 
ATOM   3466 C  CG  . LYS C 1 140 ? 8.75428   24.20434  22.01482  1.000 34.30113  ? 176 LYS E CG  1 
ATOM   3467 C  CD  . LYS C 1 140 ? 10.24582  24.10055  21.72521  1.000 32.21389  ? 176 LYS E CD  1 
ATOM   3468 C  CE  . LYS C 1 140 ? 11.04063  25.15852  22.44774  1.000 36.66914  ? 176 LYS E CE  1 
ATOM   3469 N  NZ  . LYS C 1 140 ? 12.10832  25.79253  21.60305  1.000 27.17439  ? 176 LYS E NZ  1 
ATOM   3470 N  N   . ARG C 1 141 ? 5.28885   22.91706  21.72262  1.000 22.49377  ? 177 ARG E N   1 
ATOM   3471 C  CA  . ARG C 1 141 ? 4.66106   22.18765  20.63004  1.000 26.91955  ? 177 ARG E CA  1 
ATOM   3472 C  C   . ARG C 1 141 ? 5.63884   22.16358  19.46381  1.000 29.79484  ? 177 ARG E C   1 
ATOM   3473 O  O   . ARG C 1 141 ? 6.20674   23.19846  19.10797  1.000 35.77073  ? 177 ARG E O   1 
ATOM   3474 C  CB  . ARG C 1 141 ? 3.35682   22.86762  20.21593  1.000 34.27738  ? 177 ARG E CB  1 
ATOM   3475 C  CG  . ARG C 1 141 ? 2.37417   21.99453  19.45043  1.000 44.95274  ? 177 ARG E CG  1 
ATOM   3476 C  CD  . ARG C 1 141 ? 1.43568   21.26683  20.42057  1.000 44.60369  ? 177 ARG E CD  1 
ATOM   3477 N  NE  . ARG C 1 141 ? 0.49351   20.38527  19.73600  1.000 58.50506  ? 177 ARG E NE  1 
ATOM   3478 C  CZ  . ARG C 1 141 ? 0.40354   19.07750  19.93981  1.000 56.49281  ? 177 ARG E CZ  1 
ATOM   3479 N  NH1 . ARG C 1 141 ? 1.16109   18.46423  20.84029  1.000 46.09628  ? 177 ARG E NH1 1 
ATOM   3480 N  NH2 . ARG C 1 141 ? -0.47861  18.36915  19.23545  1.000 53.58891  ? 177 ARG E NH2 1 
ATOM   3481 N  N   . ILE C 1 142 ? 5.87650   20.99361  18.88276  1.000 26.69734  ? 178 ILE E N   1 
ATOM   3482 C  CA  . ILE C 1 142 ? 6.77611   20.87455  17.73844  1.000 29.77843  ? 178 ILE E CA  1 
ATOM   3483 C  C   . ILE C 1 142 ? 6.01299   20.53759  16.46718  1.000 43.85701  ? 178 ILE E C   1 
ATOM   3484 O  O   . ILE C 1 142 ? 6.06029   21.28407  15.48792  1.000 48.05178  ? 178 ILE E O   1 
ATOM   3485 C  CB  . ILE C 1 142 ? 7.89973   19.85335  18.00967  1.000 35.94101  ? 178 ILE E CB  1 
ATOM   3486 C  CG1 . ILE C 1 142 ? 8.81351   20.39326  19.10207  1.000 37.53892  ? 178 ILE E CG1 1 
ATOM   3487 C  CG2 . ILE C 1 142 ? 8.67926   19.57430  16.73921  1.000 56.53818  ? 178 ILE E CG2 1 
ATOM   3488 C  CD1 . ILE C 1 142 ? 9.58837   21.62773  18.69105  1.000 49.95802  ? 178 ILE E CD1 1 
ATOM   3489 N  N   . PHE C 1 143 ? 5.32516   19.48101  16.46776  1.000 47.72000  ? 179 PHE E N   1 
ATOM   3490 C  CA  . PHE C 1 143 ? 4.66098   19.08112  15.24058  1.000 58.55871  ? 179 PHE E CA  1 
ATOM   3491 C  C   . PHE C 1 143 ? 3.24485   19.64669  15.19937  1.000 60.55356  ? 179 PHE E C   1 
ATOM   3492 O  O   . PHE C 1 143 ? 2.62429   19.85914  16.24747  1.000 56.52587  ? 179 PHE E O   1 
ATOM   3493 C  CB  . PHE C 1 143 ? 4.62662   17.55786  15.14192  1.000 49.81750  ? 179 PHE E CB  1 
ATOM   3494 C  CG  . PHE C 1 143 ? 5.98848   16.92976  15.19735  1.000 48.31804  ? 179 PHE E CG  1 
ATOM   3495 C  CD1 . PHE C 1 143 ? 6.76523   16.81924  14.05530  1.000 55.08282  ? 179 PHE E CD1 1 
ATOM   3496 C  CD2 . PHE C 1 143 ? 6.51758   16.50604  16.40958  1.000 49.27368  ? 179 PHE E CD2 1 
ATOM   3497 C  CE1 . PHE C 1 143 ? 8.03070   16.26139  14.11166  1.000 62.30579  ? 179 PHE E CE1 1 
ATOM   3498 C  CE2 . PHE C 1 143 ? 7.78305   15.95105  16.47601  1.000 51.89589  ? 179 PHE E CE2 1 
ATOM   3499 C  CZ  . PHE C 1 143 ? 8.54081   15.82726  15.32318  1.000 58.21952  ? 179 PHE E CZ  1 
ATOM   3500 N  N   . PRO C 1 144 ? 2.71752   19.92287  13.99415  1.000 65.94884  ? 180 PRO E N   1 
ATOM   3501 C  CA  . PRO C 1 144 ? 1.36080   20.45608  13.81378  1.000 65.87992  ? 180 PRO E CA  1 
ATOM   3502 C  C   . PRO C 1 144 ? 0.26204   19.46805  14.20527  1.000 67.32429  ? 180 PRO E C   1 
ATOM   3503 O  O   . PRO C 1 144 ? 0.41295   18.26542  13.98874  1.000 69.85251  ? 180 PRO E O   1 
ATOM   3504 C  CB  . PRO C 1 144 ? 1.30524   20.76421  12.31263  1.000 71.20183  ? 180 PRO E CB  1 
ATOM   3505 C  CG  . PRO C 1 144 ? 2.31887   19.85646  11.70222  1.000 69.32897  ? 180 PRO E CG  1 
ATOM   3506 C  CD  . PRO C 1 144 ? 3.42866   19.78946  12.71019  1.000 69.24557  ? 180 PRO E CD  1 
ATOM   3507 N  N   . LYS D 1 10  ? 12.17217  -19.26839 34.20804  1.000 61.28157  ? 46  LYS G N   1 
ATOM   3508 C  CA  . LYS D 1 10  ? 11.19267  -20.16099 33.60878  1.000 58.02436  ? 46  LYS G CA  1 
ATOM   3509 C  C   . LYS D 1 10  ? 10.85347  -19.68967 32.19120  1.000 55.83541  ? 46  LYS G C   1 
ATOM   3510 O  O   . LYS D 1 10  ? 11.29081  -18.61919 31.74242  1.000 46.08812  ? 46  LYS G O   1 
ATOM   3511 C  CB  . LYS D 1 10  ? 9.93625   -20.24114 34.48575  1.000 59.73671  ? 46  LYS G CB  1 
ATOM   3512 C  CG  . LYS D 1 10  ? 9.02190   -21.43409 34.21957  1.000 63.29435  ? 46  LYS G CG  1 
ATOM   3513 C  CD  . LYS D 1 10  ? 7.57897   -21.05108 34.46694  1.000 69.31910  ? 46  LYS G CD  1 
ATOM   3514 C  CE  . LYS D 1 10  ? 7.29417   -21.07483 35.96406  1.000 71.71811  ? 46  LYS G CE  1 
ATOM   3515 N  NZ  . LYS D 1 10  ? 5.87849   -20.77364 36.31557  1.000 66.60847  ? 46  LYS G NZ  1 
ATOM   3516 N  N   . PHE D 1 11  ? 10.08441  -20.51072 31.48668  1.000 52.55387  ? 47  PHE G N   1 
ATOM   3517 C  CA  . PHE D 1 11  ? 9.76195   -20.28803 30.08910  1.000 47.39600  ? 47  PHE G CA  1 
ATOM   3518 C  C   . PHE D 1 11  ? 8.43259   -19.57157 29.90057  1.000 41.26356  ? 47  PHE G C   1 
ATOM   3519 O  O   . PHE D 1 11  ? 7.99673   -19.39855 28.75988  1.000 37.07275  ? 47  PHE G O   1 
ATOM   3520 C  CB  . PHE D 1 11  ? 9.76479   -21.63245 29.35103  1.000 50.89122  ? 47  PHE G CB  1 
ATOM   3521 C  CG  . PHE D 1 11  ? 11.10284  -22.32437 29.38428  1.000 57.86706  ? 47  PHE G CG  1 
ATOM   3522 C  CD1 . PHE D 1 11  ? 12.24250  -21.68278 28.92096  1.000 60.34927  ? 47  PHE G CD1 1 
ATOM   3523 C  CD2 . PHE D 1 11  ? 11.23281  -23.59173 29.92606  1.000 71.39128  ? 47  PHE G CD2 1 
ATOM   3524 C  CE1 . PHE D 1 11  ? 13.48569  -22.30390 28.96672  1.000 55.22751  ? 47  PHE G CE1 1 
ATOM   3525 C  CE2 . PHE D 1 11  ? 12.47258  -24.21509 29.97703  1.000 74.57410  ? 47  PHE G CE2 1 
ATOM   3526 C  CZ  . PHE D 1 11  ? 13.59862  -23.56987 29.49334  1.000 66.63293  ? 47  PHE G CZ  1 
ATOM   3527 N  N   . ASP D 1 12  ? 7.78843   -19.13908 30.98907  1.000 39.53037  ? 48  ASP G N   1 
ATOM   3528 C  CA  . ASP D 1 12  ? 6.51913   -18.43133 30.86297  1.000 38.24149  ? 48  ASP G CA  1 
ATOM   3529 C  C   . ASP D 1 12  ? 6.68078   -17.14271 30.06190  1.000 27.20724  ? 48  ASP G C   1 
ATOM   3530 O  O   . ASP D 1 12  ? 5.80439   -16.78578 29.26512  1.000 38.01258  ? 48  ASP G O   1 
ATOM   3531 C  CB  . ASP D 1 12  ? 5.94615   -18.13714 32.24926  1.000 46.69937  ? 48  ASP G CB  1 
ATOM   3532 C  CG  . ASP D 1 12  ? 5.05062   -19.25461 32.76236  1.000 60.34258  ? 48  ASP G CG  1 
ATOM   3533 O  OD1 . ASP D 1 12  ? 4.55898   -20.05328 31.93813  1.000 70.37092  ? 48  ASP G OD1 1 
ATOM   3534 O  OD2 . ASP D 1 12  ? 4.83541   -19.33527 33.98951  1.000 63.54213  ? 48  ASP G OD2 1 
ATOM   3535 N  N   . LYS D 1 13  ? 7.80393   -16.43814 30.24452  1.000 26.03278  ? 49  LYS G N   1 
ATOM   3536 C  CA  . LYS D 1 13  ? 8.03219   -15.19037 29.52205  1.000 29.02718  ? 49  LYS G CA  1 
ATOM   3537 C  C   . LYS D 1 13  ? 8.20240   -15.39563 28.02111  1.000 28.98739  ? 49  LYS G C   1 
ATOM   3538 O  O   . LYS D 1 13  ? 8.14264   -14.41848 27.26818  1.000 29.84155  ? 49  LYS G O   1 
ATOM   3539 C  CB  . LYS D 1 13  ? 9.25786   -14.45967 30.08732  1.000 34.24978  ? 49  LYS G CB  1 
ATOM   3540 C  CG  . LYS D 1 13  ? 10.58821  -15.20932 29.99239  1.000 31.55568  ? 49  LYS G CG  1 
ATOM   3541 C  CD  . LYS D 1 13  ? 11.71699  -14.39660 30.64262  1.000 31.55774  ? 49  LYS G CD  1 
ATOM   3542 C  CE  . LYS D 1 13  ? 12.85365  -15.27299 31.14148  1.000 36.79031  ? 49  LYS G CE  1 
ATOM   3543 N  NZ  . LYS D 1 13  ? 12.39746  -16.11724 32.27630  1.000 44.59113  ? 49  LYS G NZ  1 
ATOM   3544 N  N   . LEU D 1 14  ? 8.40098   -16.62972 27.56913  1.000 23.59519  ? 50  LEU G N   1 
ATOM   3545 C  CA  . LEU D 1 14  ? 8.47966   -16.89442 26.13553  1.000 17.73932  ? 50  LEU G CA  1 
ATOM   3546 C  C   . LEU D 1 14  ? 7.10257   -16.96980 25.48210  1.000 29.23762  ? 50  LEU G C   1 
ATOM   3547 O  O   . LEU D 1 14  ? 6.98356   -16.77375 24.26433  1.000 22.91190  ? 50  LEU G O   1 
ATOM   3548 C  CB  . LEU D 1 14  ? 9.21067   -18.21926 25.89269  1.000 21.97962  ? 50  LEU G CB  1 
ATOM   3549 C  CG  . LEU D 1 14  ? 10.60462  -18.41033 26.49442  1.000 23.96867  ? 50  LEU G CG  1 
ATOM   3550 C  CD1 . LEU D 1 14  ? 11.20326  -19.74776 26.04579  1.000 25.40942  ? 50  LEU G CD1 1 
ATOM   3551 C  CD2 . LEU D 1 14  ? 11.52130  -17.26217 26.09111  1.000 22.58165  ? 50  LEU G CD2 1 
ATOM   3552 N  N   . ASP D 1 15  ? 6.06673   -17.29054 26.25480  1.000 27.73203  ? 51  ASP G N   1 
ATOM   3553 C  CA  . ASP D 1 15  ? 4.75571   -17.54677 25.66199  1.000 27.77061  ? 51  ASP G CA  1 
ATOM   3554 C  C   . ASP D 1 15  ? 4.21028   -16.39655 24.82272  1.000 28.54815  ? 51  ASP G C   1 
ATOM   3555 O  O   . ASP D 1 15  ? 3.61228   -16.68204 23.76891  1.000 33.02771  ? 51  ASP G O   1 
ATOM   3556 C  CB  . ASP D 1 15  ? 3.75403   -17.92339 26.76122  1.000 32.37060  ? 51  ASP G CB  1 
ATOM   3557 C  CG  . ASP D 1 15  ? 4.00714   -19.30283 27.32091  1.000 49.03606  ? 51  ASP G CG  1 
ATOM   3558 O  OD1 . ASP D 1 15  ? 4.64547   -20.11095 26.61264  1.000 44.33996  ? 51  ASP G OD1 1 
ATOM   3559 O  OD2 . ASP D 1 15  ? 3.57918   -19.57893 28.46678  1.000 48.87654  ? 51  ASP G OD2 1 
ATOM   3560 N  N   . PRO D 1 16  ? 4.33562   -15.11569 25.21172  1.000 25.94467  ? 52  PRO G N   1 
ATOM   3561 C  CA  . PRO D 1 16  ? 3.83456   -14.04869 24.32130  1.000 27.58326  ? 52  PRO G CA  1 
ATOM   3562 C  C   . PRO D 1 16  ? 4.50459   -14.05705 22.96208  1.000 29.99820  ? 52  PRO G C   1 
ATOM   3563 O  O   . PRO D 1 16  ? 3.90986   -13.62165 21.96494  1.000 27.04609  ? 52  PRO G O   1 
ATOM   3564 C  CB  . PRO D 1 16  ? 4.16627   -12.76255 25.09203  1.000 32.96781  ? 52  PRO G CB  1 
ATOM   3565 C  CG  . PRO D 1 16  ? 4.17986   -13.17838 26.51051  1.000 32.69249  ? 52  PRO G CG  1 
ATOM   3566 C  CD  . PRO D 1 16  ? 4.79177   -14.55790 26.50048  1.000 28.74982  ? 52  PRO G CD  1 
ATOM   3567 N  N   . TYR D 1 17  ? 5.74582   -14.52674 22.90351  1.000 23.97486  ? 53  TYR G N   1 
ATOM   3568 C  CA  . TYR D 1 17  ? 6.46156   -14.56946 21.63657  1.000 25.46085  ? 53  TYR G CA  1 
ATOM   3569 C  C   . TYR D 1 17  ? 6.11083   -15.83284 20.86880  1.000 21.08754  ? 53  TYR G C   1 
ATOM   3570 O  O   . TYR D 1 17  ? 5.92462   -15.78295 19.64650  1.000 21.25452  ? 53  TYR G O   1 
ATOM   3571 C  CB  . TYR D 1 17  ? 7.96479   -14.46684 21.89471  1.000 23.85014  ? 53  TYR G CB  1 
ATOM   3572 C  CG  . TYR D 1 17  ? 8.35506   -13.05429 22.24817  1.000 28.04864  ? 53  TYR G CG  1 
ATOM   3573 C  CD1 . TYR D 1 17  ? 8.69696   -12.14207 21.26721  1.000 27.57081  ? 53  TYR G CD1 1 
ATOM   3574 C  CD2 . TYR D 1 17  ? 8.30455   -12.61638 23.56812  1.000 39.01601  ? 53  TYR G CD2 1 
ATOM   3575 C  CE1 . TYR D 1 17  ? 9.02455   -10.83504 21.59051  1.000 43.36097  ? 53  TYR G CE1 1 
ATOM   3576 C  CE2 . TYR D 1 17  ? 8.62387   -11.31428 23.90059  1.000 34.53822  ? 53  TYR G CE2 1 
ATOM   3577 C  CZ  . TYR D 1 17  ? 8.97844   -10.43001 22.91068  1.000 37.01568  ? 53  TYR G CZ  1 
ATOM   3578 O  OH  . TYR D 1 17  ? 9.29689   -9.13574  23.24001  1.000 50.00849  ? 53  TYR G OH  1 
ATOM   3579 N  N   . PHE D 1 18  ? 6.01596   -16.96779 21.56763  1.000 21.79981  ? 54  PHE G N   1 
ATOM   3580 C  CA  . PHE D 1 18  ? 5.53984   -18.18622 20.91602  1.000 20.88505  ? 54  PHE G CA  1 
ATOM   3581 C  C   . PHE D 1 18  ? 4.19354   -17.93626 20.25828  1.000 27.21398  ? 54  PHE G C   1 
ATOM   3582 O  O   . PHE D 1 18  ? 3.90875   -18.46077 19.17423  1.000 23.92574  ? 54  PHE G O   1 
ATOM   3583 C  CB  . PHE D 1 18  ? 5.37609   -19.33819 21.91423  1.000 22.64793  ? 54  PHE G CB  1 
ATOM   3584 C  CG  . PHE D 1 18  ? 6.66068   -19.95261 22.42032  1.000 22.09524  ? 54  PHE G CG  1 
ATOM   3585 C  CD1 . PHE D 1 18  ? 7.85111   -19.88580 21.70521  1.000 15.99680  ? 54  PHE G CD1 1 
ATOM   3586 C  CD2 . PHE D 1 18  ? 6.64833   -20.65649 23.62721  1.000 21.02320  ? 54  PHE G CD2 1 
ATOM   3587 C  CE1 . PHE D 1 18  ? 9.01507   -20.48383 22.19690  1.000 17.99608  ? 54  PHE G CE1 1 
ATOM   3588 C  CE2 . PHE D 1 18  ? 7.79914   -21.24875 24.12713  1.000 17.81225  ? 54  PHE G CE2 1 
ATOM   3589 C  CZ  . PHE D 1 18  ? 8.99150   -21.17229 23.40754  1.000 19.03426  ? 54  PHE G CZ  1 
ATOM   3590 N  N   . GLN D 1 19  ? 3.34263   -17.14060 20.91473  1.000 24.03999  ? 55  GLN G N   1 
ATOM   3591 C  CA  . GLN D 1 19  ? 2.01456   -16.88656 20.37684  1.000 29.95511  ? 55  GLN G CA  1 
ATOM   3592 C  C   . GLN D 1 19  ? 2.06391   -16.05255 19.10218  1.000 28.79939  ? 55  GLN G C   1 
ATOM   3593 O  O   . GLN D 1 19  ? 1.07123   -16.00312 18.37083  1.000 32.76607  ? 55  GLN G O   1 
ATOM   3594 C  CB  . GLN D 1 19  ? 1.14633   -16.20258 21.43684  1.000 38.41708  ? 55  GLN G CB  1 
ATOM   3595 C  CG  . GLN D 1 19  ? 0.55836   -17.15431 22.48637  1.000 49.81071  ? 55  GLN G CG  1 
ATOM   3596 C  CD  . GLN D 1 19  ? -0.51221  -18.10404 21.94561  1.000 72.03304  ? 55  GLN G CD  1 
ATOM   3597 O  OE1 . GLN D 1 19  ? -0.24532  -18.95613 21.08929  1.000 67.42865  ? 55  GLN G OE1 1 
ATOM   3598 N  NE2 . GLN D 1 19  ? -1.73314  -17.96676 22.46097  1.000 82.48465  ? 55  GLN G NE2 1 
ATOM   3599 N  N   . GLN D 1 20  ? 3.18908   -15.40286 18.81170  1.000 23.65497  ? 56  GLN G N   1 
ATOM   3600 C  CA  . GLN D 1 20  ? 3.36118   -14.69863 17.54664  1.000 26.78944  ? 56  GLN G CA  1 
ATOM   3601 C  C   . GLN D 1 20  ? 4.27797   -15.42775 16.57300  1.000 22.25073  ? 56  GLN G C   1 
ATOM   3602 O  O   . GLN D 1 20  ? 4.63958   -14.85752 15.53539  1.000 24.98782  ? 56  GLN G O   1 
ATOM   3603 C  CB  . GLN D 1 20  ? 3.87169   -13.27928 17.78222  1.000 26.59202  ? 56  GLN G CB  1 
ATOM   3604 C  CG  . GLN D 1 20  ? 2.95996   -12.47614 18.68324  1.000 32.70372  ? 56  GLN G CG  1 
ATOM   3605 C  CD  . GLN D 1 20  ? 1.59829   -12.30006 18.04309  1.000 42.92798  ? 56  GLN G CD  1 
ATOM   3606 O  OE1 . GLN D 1 20  ? 0.59620   -12.81880 18.53818  1.000 55.64379  ? 56  GLN G OE1 1 
ATOM   3607 N  NE2 . GLN D 1 20  ? 1.56613   -11.63314 16.89635  1.000 42.96756  ? 56  GLN G NE2 1 
ATOM   3608 N  N   . GLY D 1 21  ? 4.63922   -16.67163 16.86620  1.000 19.09960  ? 57  GLY G N   1 
ATOM   3609 C  CA  . GLY D 1 21  ? 5.38987   -17.49945 15.94126  1.000 20.73862  ? 57  GLY G CA  1 
ATOM   3610 C  C   . GLY D 1 21  ? 6.88876   -17.48759 16.12504  1.000 20.16855  ? 57  GLY G C   1 
ATOM   3611 O  O   . GLY D 1 21  ? 7.59707   -18.07487 15.29286  1.000 18.24877  ? 57  GLY G O   1 
ATOM   3612 N  N   . TRP D 1 22  ? 7.39545   -16.84255 17.18118  1.000 18.78862  ? 58  TRP G N   1 
ATOM   3613 C  CA  . TRP D 1 22  ? 8.81356   -16.91702 17.51494  1.000 15.58292  ? 58  TRP G CA  1 
ATOM   3614 C  C   . TRP D 1 22  ? 9.14744   -18.28296 18.10786  1.000 17.53798  ? 58  TRP G C   1 
ATOM   3615 O  O   . TRP D 1 22  ? 8.28000   -18.99593 18.62102  1.000 16.65703  ? 58  TRP G O   1 
ATOM   3616 C  CB  . TRP D 1 22  ? 9.19058   -15.82944 18.54081  1.000 15.57793  ? 58  TRP G CB  1 
ATOM   3617 C  CG  . TRP D 1 22  ? 8.97749   -14.39749 18.07611  1.000 18.00853  ? 58  TRP G CG  1 
ATOM   3618 C  CD1 . TRP D 1 22  ? 7.79060   -13.80393 17.76467  1.000 18.21725  ? 58  TRP G CD1 1 
ATOM   3619 C  CD2 . TRP D 1 22  ? 9.98956   -13.39199 17.89813  1.000 18.05477  ? 58  TRP G CD2 1 
ATOM   3620 N  NE1 . TRP D 1 22  ? 7.99752   -12.49128 17.39628  1.000 24.79958  ? 58  TRP G NE1 1 
ATOM   3621 C  CE2 . TRP D 1 22  ? 9.33847   -12.21553 17.46736  1.000 22.54665  ? 58  TRP G CE2 1 
ATOM   3622 C  CE3 . TRP D 1 22  ? 11.38465  -13.38021 18.04725  1.000 17.87467  ? 58  TRP G CE3 1 
ATOM   3623 C  CZ2 . TRP D 1 22  ? 10.03181  -11.02906 17.18538  1.000 20.71183  ? 58  TRP G CZ2 1 
ATOM   3624 C  CZ3 . TRP D 1 22  ? 12.07602  -12.19618 17.77257  1.000 20.16532  ? 58  TRP G CZ3 1 
ATOM   3625 C  CH2 . TRP D 1 22  ? 11.39768  -11.04047 17.33873  1.000 17.13396  ? 58  TRP G CH2 1 
ATOM   3626 N  N   . PHE D 1 23  ? 10.42483  -18.64779 18.04505  1.000 13.83987  ? 59  PHE G N   1 
ATOM   3627 C  CA  . PHE D 1 23  ? 10.86897  -19.91523 18.61930  1.000 16.13430  ? 59  PHE G CA  1 
ATOM   3628 C  C   . PHE D 1 23  ? 12.24695  -19.73687 19.25358  1.000 16.66847  ? 59  PHE G C   1 
ATOM   3629 O  O   . PHE D 1 23  ? 12.98421  -18.78605 18.96024  1.000 15.14868  ? 59  PHE G O   1 
ATOM   3630 C  CB  . PHE D 1 23  ? 10.85951  -21.03475 17.55013  1.000 16.33078  ? 59  PHE G CB  1 
ATOM   3631 C  CG  . PHE D 1 23  ? 11.51519  -20.63563 16.26670  1.000 16.17838  ? 59  PHE G CG  1 
ATOM   3632 C  CD1 . PHE D 1 23  ? 10.78171  -20.00262 15.27126  1.000 15.66039  ? 59  PHE G CD1 1 
ATOM   3633 C  CD2 . PHE D 1 23  ? 12.85641  -20.92658 16.03869  1.000 19.01649  ? 59  PHE G CD2 1 
ATOM   3634 C  CE1 . PHE D 1 23  ? 11.39870  -19.60383 14.08138  1.000 18.35891  ? 59  PHE G CE1 1 
ATOM   3635 C  CE2 . PHE D 1 23  ? 13.47296  -20.55771 14.85932  1.000 16.75930  ? 59  PHE G CE2 1 
ATOM   3636 C  CZ  . PHE D 1 23  ? 12.73799  -19.90127 13.86759  1.000 16.36202  ? 59  PHE G CZ  1 
ATOM   3637 N  N   . HIS D 1 24  ? 12.58399  -20.66935 20.14241  1.000 16.24926  ? 60  HIS G N   1 
ATOM   3638 C  CA  . HIS D 1 24  ? 13.66176  -20.50527 21.11163  1.000 16.95161  ? 60  HIS G CA  1 
ATOM   3639 C  C   . HIS D 1 24  ? 14.81686  -21.43925 20.77689  1.000 15.33700  ? 60  HIS G C   1 
ATOM   3640 O  O   . HIS D 1 24  ? 14.62518  -22.65054 20.60773  1.000 17.46379  ? 60  HIS G O   1 
ATOM   3641 C  CB  . HIS D 1 24  ? 13.10689  -20.77210 22.51806  1.000 17.09484  ? 60  HIS G CB  1 
ATOM   3642 C  CG  . HIS D 1 24  ? 14.15015  -20.93548 23.57493  1.000 16.06930  ? 60  HIS G CG  1 
ATOM   3643 N  ND1 . HIS D 1 24  ? 14.01814  -21.83452 24.61290  1.000 20.55662  ? 60  HIS G ND1 1 
ATOM   3644 C  CD2 . HIS D 1 24  ? 15.33194  -20.30656 23.76533  1.000 17.61472  ? 60  HIS G CD2 1 
ATOM   3645 C  CE1 . HIS D 1 24  ? 15.08598  -21.76407 25.38958  1.000 19.38137  ? 60  HIS G CE1 1 
ATOM   3646 N  NE2 . HIS D 1 24  ? 15.90019  -20.84556 24.89547  1.000 18.77258  ? 60  HIS G NE2 1 
ATOM   3647 N  N   . PHE D 1 25  ? 16.01758  -20.86962 20.67864  1.000 14.37200  ? 61  PHE G N   1 
ATOM   3648 C  CA  . PHE D 1 25  ? 17.23665  -21.63236 20.46211  1.000 14.17944  ? 61  PHE G CA  1 
ATOM   3649 C  C   . PHE D 1 25  ? 18.31175  -20.98570 21.32255  1.000 18.77587  ? 61  PHE G C   1 
ATOM   3650 O  O   . PHE D 1 25  ? 18.56394  -19.78488 21.18303  1.000 17.19322  ? 61  PHE G O   1 
ATOM   3651 C  CB  . PHE D 1 25  ? 17.63099  -21.62354 18.97429  1.000 16.12128  ? 61  PHE G CB  1 
ATOM   3652 C  CG  . PHE D 1 25  ? 18.94297  -22.28807 18.69506  1.000 14.26556  ? 61  PHE G CG  1 
ATOM   3653 C  CD1 . PHE D 1 25  ? 19.04968  -23.67780 18.73645  1.000 15.16737  ? 61  PHE G CD1 1 
ATOM   3654 C  CD2 . PHE D 1 25  ? 20.06303  -21.53239 18.39548  1.000 15.56545  ? 61  PHE G CD2 1 
ATOM   3655 C  CE1 . PHE D 1 25  ? 20.25683  -24.31600 18.48590  1.000 15.95695  ? 61  PHE G CE1 1 
ATOM   3656 C  CE2 . PHE D 1 25  ? 21.28430  -22.16588 18.12273  1.000 20.73025  ? 61  PHE G CE2 1 
ATOM   3657 C  CZ  . PHE D 1 25  ? 21.38583  -23.55687 18.19121  1.000 16.09743  ? 61  PHE G CZ  1 
ATOM   3658 N  N   . GLN D 1 26  ? 18.90201  -21.76985 22.23407  1.000 18.21480  ? 62  GLN G N   1 
ATOM   3659 C  CA  . GLN D 1 26  ? 19.97692  -21.32034 23.12894  1.000 17.34691  ? 62  GLN G CA  1 
ATOM   3660 C  C   . GLN D 1 26  ? 19.41323  -20.17276 23.95726  1.000 20.57925  ? 62  GLN G C   1 
ATOM   3661 O  O   . GLN D 1 26  ? 18.42497  -20.37781 24.68092  1.000 27.82956  ? 62  GLN G O   1 
ATOM   3662 C  CB  . GLN D 1 26  ? 21.25702  -21.00051 22.34543  1.000 20.30006  ? 62  GLN G CB  1 
ATOM   3663 C  CG  . GLN D 1 26  ? 21.94027  -22.20749 21.72932  1.000 23.91963  ? 62  GLN G CG  1 
ATOM   3664 C  CD  . GLN D 1 26  ? 23.18328  -21.82036 20.92112  1.000 25.91283  ? 62  GLN G CD  1 
ATOM   3665 O  OE1 . GLN D 1 26  ? 23.30983  -20.68706 20.42753  1.000 37.54344  ? 62  GLN G OE1 1 
ATOM   3666 N  NE2 . GLN D 1 26  ? 24.09404  -22.76464 20.77590  1.000 29.76097  ? 62  GLN G NE2 1 
ATOM   3667 N  N   . LYS D 1 27  ? 19.96822  -18.97117 23.89867  1.000 23.57608  ? 63  LYS G N   1 
ATOM   3668 C  CA  . LYS D 1 27  ? 19.49597  -17.94895 24.82204  1.000 22.78811  ? 63  LYS G CA  1 
ATOM   3669 C  C   . LYS D 1 27  ? 18.51752  -16.97543 24.18505  1.000 23.30559  ? 63  LYS G C   1 
ATOM   3670 O  O   . LYS D 1 27  ? 18.11099  -16.00246 24.83558  1.000 20.33410  ? 63  LYS G O   1 
ATOM   3671 C  CB  . LYS D 1 27  ? 20.68705  -17.21220 25.43089  1.000 26.54244  ? 63  LYS G CB  1 
ATOM   3672 C  CG  . LYS D 1 27  ? 21.60191  -18.14554 26.21870  1.000 39.99932  ? 63  LYS G CG  1 
ATOM   3673 C  CD  . LYS D 1 27  ? 22.67991  -17.37337 26.96905  1.000 42.71816  ? 63  LYS G CD  1 
ATOM   3674 C  CE  . LYS D 1 27  ? 23.53935  -18.30689 27.80671  1.000 49.26417  ? 63  LYS G CE  1 
ATOM   3675 N  NZ  . LYS D 1 27  ? 24.81349  -17.65709 28.20991  1.000 47.25767  ? 63  LYS G NZ  1 
ATOM   3676 N  N   . SER D 1 28  ? 18.07929  -17.23851 22.95186  1.000 15.90023  ? 64  SER G N   1 
ATOM   3677 C  CA  . SER D 1 28  ? 17.36214  -16.22665 22.20467  1.000 15.58134  ? 64  SER G CA  1 
ATOM   3678 C  C   . SER D 1 28  ? 16.04055  -16.73309 21.65612  1.000 15.50562  ? 64  SER G C   1 
ATOM   3679 O  O   . SER D 1 28  ? 15.83222  -17.93454 21.45698  1.000 16.73632  ? 64  SER G O   1 
ATOM   3680 C  CB  . SER D 1 28  ? 18.20608  -15.72710 21.02992  1.000 18.42251  ? 64  SER G CB  1 
ATOM   3681 O  OG  . SER D 1 28  ? 19.40883  -15.13291 21.47191  1.000 21.74683  ? 64  SER G OG  1 
ATOM   3682 N  N   . LEU D 1 29  ? 15.17896  -15.77213 21.34581  1.000 15.92968  ? 65  LEU G N   1 
ATOM   3683 C  CA  . LEU D 1 29  ? 14.01450  -16.02231 20.51067  1.000 15.74766  ? 65  LEU G CA  1 
ATOM   3684 C  C   . LEU D 1 29  ? 14.33201  -15.55307 19.09711  1.000 16.56580  ? 65  LEU G C   1 
ATOM   3685 O  O   . LEU D 1 29  ? 15.05582  -14.56893 18.89519  1.000 15.98798  ? 65  LEU G O   1 
ATOM   3686 C  CB  . LEU D 1 29  ? 12.78864  -15.27013 21.03367  1.000 17.07954  ? 65  LEU G CB  1 
ATOM   3687 C  CG  . LEU D 1 29  ? 12.11501  -15.90278 22.25878  1.000 19.95525  ? 65  LEU G CG  1 
ATOM   3688 C  CD1 . LEU D 1 29  ? 11.26321  -14.84450 22.97762  1.000 18.77721  ? 65  LEU G CD1 1 
ATOM   3689 C  CD2 . LEU D 1 29  ? 11.25629  -17.10906 21.85548  1.000 20.07660  ? 65  LEU G CD2 1 
ATOM   3690 N  N   . TYR D 1 30  ? 13.78875  -16.27543 18.11923  1.000 14.78562  ? 66  TYR G N   1 
ATOM   3691 C  CA  . TYR D 1 30  ? 14.00598  -15.95174 16.71772  1.000 16.45433  ? 66  TYR G CA  1 
ATOM   3692 C  C   . TYR D 1 30  ? 12.67169  -15.84976 16.00613  1.000 14.19768  ? 66  TYR G C   1 
ATOM   3693 O  O   . TYR D 1 30  ? 11.69831  -16.52696 16.36057  1.000 14.92108  ? 66  TYR G O   1 
ATOM   3694 C  CB  . TYR D 1 30  ? 14.86230  -17.00871 16.01588  1.000 14.11117  ? 66  TYR G CB  1 
ATOM   3695 C  CG  . TYR D 1 30  ? 16.24545  -17.13334 16.59691  1.000 15.17093  ? 66  TYR G CG  1 
ATOM   3696 C  CD1 . TYR D 1 30  ? 16.47114  -17.92013 17.72190  1.000 14.62913  ? 66  TYR G CD1 1 
ATOM   3697 C  CD2 . TYR D 1 30  ? 17.32415  -16.46897 16.02399  1.000 15.49356  ? 66  TYR G CD2 1 
ATOM   3698 C  CE1 . TYR D 1 30  ? 17.73625  -18.04657 18.26532  1.000 14.01260  ? 66  TYR G CE1 1 
ATOM   3699 C  CE2 . TYR D 1 30  ? 18.60193  -16.59382 16.55928  1.000 14.54919  ? 66  TYR G CE2 1 
ATOM   3700 C  CZ  . TYR D 1 30  ? 18.79555  -17.37933 17.68961  1.000 17.13404  ? 66  TYR G CZ  1 
ATOM   3701 O  OH  . TYR D 1 30  ? 20.05948  -17.52872 18.23222  1.000 17.64623  ? 66  TYR G OH  1 
ATOM   3702 N  N   . TYR D 1 31  ? 12.65626  -15.03266 14.95785  1.000 13.43857  ? 67  TYR G N   1 
ATOM   3703 C  CA  . TYR D 1 31  ? 11.46048  -14.83744 14.16007  1.000 16.71866  ? 67  TYR G CA  1 
ATOM   3704 C  C   . TYR D 1 31  ? 11.88289  -14.89928 12.71272  1.000 14.80948  ? 67  TYR G C   1 
ATOM   3705 O  O   . TYR D 1 31  ? 12.82621  -14.20771 12.32053  1.000 17.41882  ? 67  TYR G O   1 
ATOM   3706 C  CB  . TYR D 1 31  ? 10.82881  -13.48280 14.45390  1.000 19.56365  ? 67  TYR G CB  1 
ATOM   3707 C  CG  . TYR D 1 31  ? 9.73193   -13.04007 13.50218  1.000 18.21477  ? 67  TYR G CG  1 
ATOM   3708 C  CD1 . TYR D 1 31  ? 10.03097  -12.23075 12.40733  1.000 20.93789  ? 67  TYR G CD1 1 
ATOM   3709 C  CD2 . TYR D 1 31  ? 8.40184   -13.32055 13.76441  1.000 22.19384  ? 67  TYR G CD2 1 
ATOM   3710 C  CE1 . TYR D 1 31  ? 9.03252   -11.76609 11.55874  1.000 20.01108  ? 67  TYR G CE1 1 
ATOM   3711 C  CE2 . TYR D 1 31  ? 7.38436   -12.84968 12.90740  1.000 21.73093  ? 67  TYR G CE2 1 
ATOM   3712 C  CZ  . TYR D 1 31  ? 7.71870   -12.07956 11.81752  1.000 22.07771  ? 67  TYR G CZ  1 
ATOM   3713 O  OH  . TYR D 1 31  ? 6.73234   -11.60662 10.96299  1.000 30.04210  ? 67  TYR G OH  1 
ATOM   3714 N  N   . ILE D 1 32  ? 11.18656  -15.72234 11.93621  1.000 14.57423  ? 68  ILE G N   1 
ATOM   3715 C  CA  . ILE D 1 32  ? 11.36299  -15.79606 10.48859  1.000 13.46749  ? 68  ILE G CA  1 
ATOM   3716 C  C   . ILE D 1 32  ? 10.16972  -15.10531 9.84299   1.000 13.54996  ? 68  ILE G C   1 
ATOM   3717 O  O   . ILE D 1 32  ? 9.01488   -15.43779 10.15067  1.000 15.24512  ? 68  ILE G O   1 
ATOM   3718 C  CB  . ILE D 1 32  ? 11.46197  -17.25645 10.02317  1.000 13.73316  ? 68  ILE G CB  1 
ATOM   3719 C  CG1 . ILE D 1 32  ? 12.80260  -17.86511 10.48100  1.000 14.99942  ? 68  ILE G CG1 1 
ATOM   3720 C  CG2 . ILE D 1 32  ? 11.33771  -17.30553 8.49630   1.000 13.59643  ? 68  ILE G CG2 1 
ATOM   3721 C  CD1 . ILE D 1 32  ? 12.94738  -19.35913 10.15715  1.000 19.39902  ? 68  ILE G CD1 1 
ATOM   3722 N  N   . SER D 1 33  ? 10.44100  -14.15402 8.94775   1.000 12.43169  ? 69  SER G N   1 
ATOM   3723 C  CA  . SER D 1 33  ? 9.34794   -13.35085 8.41271   1.000 13.41499  ? 69  SER G CA  1 
ATOM   3724 C  C   . SER D 1 33  ? 8.51863   -14.16451 7.43227   1.000 15.45741  ? 69  SER G C   1 
ATOM   3725 O  O   . SER D 1 33  ? 8.95635   -15.19317 6.90997   1.000 16.13606  ? 69  SER G O   1 
ATOM   3726 C  CB  . SER D 1 33  ? 9.86703   -12.10027 7.70889   1.000 15.15156  ? 69  SER G CB  1 
ATOM   3727 O  OG  . SER D 1 33  ? 10.58028  -12.45468 6.52703   1.000 13.38650  ? 69  SER G OG  1 
ATOM   3728 N  N   . SER D 1 34  ? 7.28886   -13.69228 7.19772   1.000 16.16277  ? 70  SER G N   1 
ATOM   3729 C  CA  A SER D 1 34  ? 6.45413   -14.28668 6.15892   0.732 16.34407  ? 70  SER G CA  1 
ATOM   3730 C  CA  B SER D 1 34  ? 6.39664   -14.24649 6.18671   0.268 16.44689  ? 70  SER G CA  1 
ATOM   3731 C  C   . SER D 1 34  ? 6.36922   -13.41412 4.91403   1.000 18.72670  ? 70  SER G C   1 
ATOM   3732 O  O   . SER D 1 34  ? 5.70980   -13.80780 3.93896   1.000 19.10599  ? 70  SER G O   1 
ATOM   3733 C  CB  A SER D 1 34  ? 5.04756   -14.58242 6.70445   0.732 23.85993  ? 70  SER G CB  1 
ATOM   3734 C  CB  B SER D 1 34  ? 4.96790   -14.35418 6.73685   0.268 23.86281  ? 70  SER G CB  1 
ATOM   3735 O  OG  A SER D 1 34  ? 4.43229   -13.40915 7.20851   0.732 24.09459  ? 70  SER G OG  1 
ATOM   3736 O  OG  B SER D 1 34  ? 4.92535   -15.13734 7.90941   0.268 18.98516  ? 70  SER G OG  1 
ATOM   3737 N  N   . VAL D 1 35  ? 7.04129   -12.26353 4.90953   1.000 16.56878  ? 71  VAL G N   1 
ATOM   3738 C  CA  . VAL D 1 35  ? 7.09959   -11.38565 3.74866   1.000 15.67024  ? 71  VAL G CA  1 
ATOM   3739 C  C   . VAL D 1 35  ? 8.56136   -11.05915 3.49680   1.000 16.73442  ? 71  VAL G C   1 
ATOM   3740 O  O   . VAL D 1 35  ? 9.39615   -11.15351 4.39335   1.000 15.84782  ? 71  VAL G O   1 
ATOM   3741 C  CB  . VAL D 1 35  ? 6.31955   -10.06563 3.94478   1.000 14.08233  ? 71  VAL G CB  1 
ATOM   3742 C  CG1 . VAL D 1 35  ? 4.81405   -10.35612 4.11513   1.000 18.36181  ? 71  VAL G CG1 1 
ATOM   3743 C  CG2 . VAL D 1 35  ? 6.88676   -9.26278  5.12572   1.000 16.46648  ? 71  VAL G CG2 1 
ATOM   3744 N  N   . LYS D 1 36  ? 8.86132   -10.63351 2.27275   1.000 13.10947  ? 72  LYS G N   1 
ATOM   3745 C  CA  . LYS D 1 36  ? 10.20465  -10.12210 2.00567   1.000 13.60482  ? 72  LYS G CA  1 
ATOM   3746 C  C   . LYS D 1 36  ? 10.25739  -8.60989  2.22156   1.000 16.04034  ? 72  LYS G C   1 
ATOM   3747 O  O   . LYS D 1 36  ? 9.24111   -7.90441  2.16384   1.000 15.15992  ? 72  LYS G O   1 
ATOM   3748 C  CB  . LYS D 1 36  ? 10.63247  -10.46049 0.58199   1.000 13.88649  ? 72  LYS G CB  1 
ATOM   3749 C  CG  . LYS D 1 36  ? 10.63517  -11.97313 0.31169   1.000 16.55834  ? 72  LYS G CG  1 
ATOM   3750 C  CD  . LYS D 1 36  ? 11.41234  -12.26643 -0.95355  1.000 16.93395  ? 72  LYS G CD  1 
ATOM   3751 C  CE  . LYS D 1 36  ? 11.55487  -13.76541 -1.18671  1.000 20.18984  ? 72  LYS G CE  1 
ATOM   3752 N  NZ  . LYS D 1 36  ? 12.23190  -14.03000 -2.49879  1.000 18.93245  ? 72  LYS G NZ  1 
ATOM   3753 N  N   . ASN D 1 37  ? 11.45766  -8.10073  2.48142   1.000 13.99061  ? 73  ASN G N   1 
ATOM   3754 C  CA  . ASN D 1 37  ? 11.55970  -6.65132  2.57478   1.000 11.90325  ? 73  ASN G CA  1 
ATOM   3755 C  C   . ASN D 1 37  ? 13.00141  -6.22774  2.34954   1.000 14.48549  ? 73  ASN G C   1 
ATOM   3756 O  O   . ASN D 1 37  ? 13.90967  -7.06296  2.25840   1.000 15.28756  ? 73  ASN G O   1 
ATOM   3757 C  CB  . ASN D 1 37  ? 11.05652  -6.13175  3.91748   1.000 13.09925  ? 73  ASN G CB  1 
ATOM   3758 C  CG  . ASN D 1 37  ? 10.16160  -4.92486  3.74129   1.000 15.20578  ? 73  ASN G CG  1 
ATOM   3759 O  OD1 . ASN D 1 37  ? 10.35632  -4.14382  2.80134   1.000 15.65085  ? 73  ASN G OD1 1 
ATOM   3760 N  ND2 . ASN D 1 37  ? 9.13451   -4.81298  4.57449   1.000 14.55691  ? 73  ASN G ND2 1 
ATOM   3761 N  N   . THR D 1 38  ? 13.18820  -4.90759  2.21976   1.000 15.31736  ? 74  THR G N   1 
ATOM   3762 C  CA  . THR D 1 38  ? 14.53546  -4.36888  2.11649   1.000 15.02833  ? 74  THR G CA  1 
ATOM   3763 C  C   . THR D 1 38  ? 15.25934  -4.63647  3.42333   1.000 15.75956  ? 74  THR G C   1 
ATOM   3764 O  O   . THR D 1 38  ? 14.63995  -4.88985  4.44691   1.000 14.88790  ? 74  THR G O   1 
ATOM   3765 C  CB  . THR D 1 38  ? 14.51782  -2.86609  1.85849   1.000 18.88461  ? 74  THR G CB  1 
ATOM   3766 O  OG1 . THR D 1 38  ? 13.98398  -2.19788  3.01197   1.000 15.98678  ? 74  THR G OG1 1 
ATOM   3767 C  CG2 . THR D 1 38  ? 13.66214  -2.52743  0.61466   1.000 16.01673  ? 74  THR G CG2 1 
ATOM   3768 N  N   . TRP D 1 39  ? 16.59151  -4.54327  3.40210   1.000 13.65811  ? 75  TRP G N   1 
ATOM   3769 C  CA  . TRP D 1 39  ? 17.30263  -4.77496  4.65834   1.000 14.01912  ? 75  TRP G CA  1 
ATOM   3770 C  C   . TRP D 1 39  ? 16.84435  -3.78544  5.72441   1.000 15.10158  ? 75  TRP G C   1 
ATOM   3771 O  O   . TRP D 1 39  ? 16.59858  -4.16711  6.87560   1.000 13.64724  ? 75  TRP G O   1 
ATOM   3772 C  CB  . TRP D 1 39  ? 18.81150  -4.65492  4.44169   1.000 14.30322  ? 75  TRP G CB  1 
ATOM   3773 C  CG  . TRP D 1 39  ? 19.64463  -5.07388  5.63776   1.000 13.58728  ? 75  TRP G CG  1 
ATOM   3774 C  CD1 . TRP D 1 39  ? 20.16202  -6.32353  5.86739   1.000 14.75277  ? 75  TRP G CD1 1 
ATOM   3775 C  CD2 . TRP D 1 39  ? 20.06815  -4.25167  6.74882   1.000 14.24101  ? 75  TRP G CD2 1 
ATOM   3776 N  NE1 . TRP D 1 39  ? 20.88374  -6.32439  7.04251   1.000 15.01208  ? 75  TRP G NE1 1 
ATOM   3777 C  CE2 . TRP D 1 39  ? 20.84463  -5.07434  7.60349   1.000 14.21619  ? 75  TRP G CE2 1 
ATOM   3778 C  CE3 . TRP D 1 39  ? 19.88124  -2.90502  7.09302   1.000 16.21311  ? 75  TRP G CE3 1 
ATOM   3779 C  CZ2 . TRP D 1 39  ? 21.42577  -4.59779  8.78939   1.000 14.78364  ? 75  TRP G CZ2 1 
ATOM   3780 C  CZ3 . TRP D 1 39  ? 20.46108  -2.42306  8.29350   1.000 17.61540  ? 75  TRP G CZ3 1 
ATOM   3781 C  CH2 . TRP D 1 39  ? 21.22179  -3.27003  9.11848   1.000 15.86265  ? 75  TRP G CH2 1 
ATOM   3782 N  N   . HIS D 1 40  ? 16.68876  -2.51187  5.34764   1.000 14.92294  ? 76  HIS G N   1 
ATOM   3783 C  CA  . HIS D 1 40  ? 16.34197  -1.50065  6.34434   1.000 15.77437  ? 76  HIS G CA  1 
ATOM   3784 C  C   . HIS D 1 40  ? 14.93128  -1.68160  6.88908   1.000 16.33879  ? 76  HIS G C   1 
ATOM   3785 O  O   . HIS D 1 40  ? 14.72144  -1.52339  8.08862   1.000 14.43680  ? 76  HIS G O   1 
ATOM   3786 C  CB  . HIS D 1 40  ? 16.51305  -0.10680  5.75014   1.000 14.19419  ? 76  HIS G CB  1 
ATOM   3787 C  CG  . HIS D 1 40  ? 17.95046  0.21137   5.46253   1.000 17.95614  ? 76  HIS G CG  1 
ATOM   3788 N  ND1 . HIS D 1 40  ? 18.48371  0.17417   4.19357   1.000 31.99133  ? 76  HIS G ND1 1 
ATOM   3789 C  CD2 . HIS D 1 40  ? 18.97635  0.50555   6.29353   1.000 24.16282  ? 76  HIS G CD2 1 
ATOM   3790 C  CE1 . HIS D 1 40  ? 19.77116  0.46622   4.25078   1.000 23.57431  ? 76  HIS G CE1 1 
ATOM   3791 N  NE2 . HIS D 1 40  ? 20.09572  0.66517   5.51534   1.000 25.41561  ? 76  HIS G NE2 1 
ATOM   3792 N  N   . LEU D 1 41  ? 13.95575  -2.00761  6.03462   1.000 15.92152  ? 77  LEU G N   1 
ATOM   3793 C  CA  . LEU D 1 41  ? 12.59327  -2.21887  6.53896   1.000 14.72609  ? 77  LEU G CA  1 
ATOM   3794 C  C   . LEU D 1 41  ? 12.46573  -3.54149  7.29420   1.000 15.23790  ? 77  LEU G C   1 
ATOM   3795 O  O   . LEU D 1 41  ? 11.62379  -3.65576  8.19368   1.000 17.44617  ? 77  LEU G O   1 
ATOM   3796 C  CB  . LEU D 1 41  ? 11.59203  -2.17908  5.37801   1.000 14.90427  ? 77  LEU G CB  1 
ATOM   3797 C  CG  . LEU D 1 41  ? 11.39494  -0.77857  4.77543   1.000 20.30446  ? 77  LEU G CG  1 
ATOM   3798 C  CD1 . LEU D 1 41  ? 10.48380  -0.85989  3.55867   1.000 21.25079  ? 77  LEU G CD1 1 
ATOM   3799 C  CD2 . LEU D 1 41  ? 10.82281  0.18103   5.81570   1.000 24.22928  ? 77  LEU G CD2 1 
ATOM   3800 N  N   . SER D 1 42  ? 13.26197  -4.55566  6.93059   1.000 13.11747  ? 78  SER G N   1 
ATOM   3801 C  CA  . SER D 1 42  ? 13.34604  -5.75362  7.76473   1.000 14.99557  ? 78  SER G CA  1 
ATOM   3802 C  C   . SER D 1 42  ? 13.80461  -5.38359  9.16710   1.000 15.47640  ? 78  SER G C   1 
ATOM   3803 O  O   . SER D 1 42  ? 13.22270  -5.81787  10.16819  1.000 15.37570  ? 78  SER G O   1 
ATOM   3804 C  CB  . SER D 1 42  ? 14.32364  -6.76487  7.16536   1.000 14.21620  ? 78  SER G CB  1 
ATOM   3805 O  OG  . SER D 1 42  ? 13.89819  -7.16685  5.86439   1.000 14.09681  ? 78  SER G OG  1 
ATOM   3806 N  N   . ARG D 1 43  ? 14.86731  -4.59006  9.25375   1.000 14.76452  ? 79  ARG G N   1 
ATOM   3807 C  CA  . ARG D 1 43  ? 15.35541  -4.20048  10.57006  1.000 12.93853  ? 79  ARG G CA  1 
ATOM   3808 C  C   . ARG D 1 43  ? 14.29527  -3.41408  11.32894  1.000 16.21020  ? 79  ARG G C   1 
ATOM   3809 O  O   . ARG D 1 43  ? 14.11749  -3.61233  12.53941  1.000 17.92661  ? 79  ARG G O   1 
ATOM   3810 C  CB  . ARG D 1 43  ? 16.65014  -3.39224  10.45411  1.000 14.26118  ? 79  ARG G CB  1 
ATOM   3811 C  CG  . ARG D 1 43  ? 17.29927  -3.26621  11.83998  1.000 15.53615  ? 79  ARG G CG  1 
ATOM   3812 C  CD  . ARG D 1 43  ? 18.50419  -2.33025  11.87717  1.000 16.23783  ? 79  ARG G CD  1 
ATOM   3813 N  NE  . ARG D 1 43  ? 19.07540  -2.39396  13.21882  1.000 17.10703  ? 79  ARG G NE  1 
ATOM   3814 C  CZ  . ARG D 1 43  ? 19.80512  -1.43408  13.76828  1.000 21.72822  ? 79  ARG G CZ  1 
ATOM   3815 N  NH1 . ARG D 1 43  ? 20.14892  -0.35122  13.08268  1.000 26.83570  ? 79  ARG G NH1 1 
ATOM   3816 N  NH2 . ARG D 1 43  ? 20.19380  -1.56169  15.03643  1.000 21.28802  ? 79  ARG G NH2 1 
ATOM   3817 N  N   . GLU D 1 44  ? 13.57247  -2.52468  10.63737  1.000 17.39377  ? 80  GLU G N   1 
ATOM   3818 C  CA  . GLU D 1 44  ? 12.52867  -1.75668  11.31504  1.000 15.40296  ? 80  GLU G CA  1 
ATOM   3819 C  C   . GLU D 1 44  ? 11.48715  -2.67969  11.92038  1.000 19.38323  ? 80  GLU G C   1 
ATOM   3820 O  O   . GLU D 1 44  ? 10.97703  -2.41387  13.01624  1.000 20.97138  ? 80  GLU G O   1 
ATOM   3821 C  CB  . GLU D 1 44  ? 11.84367  -0.77878  10.35590  1.000 17.26241  ? 80  GLU G CB  1 
ATOM   3822 C  CG  . GLU D 1 44  ? 12.69086  0.41654   9.95129   1.000 23.74067  ? 80  GLU G CG  1 
ATOM   3823 C  CD  . GLU D 1 44  ? 11.88951  1.44329   9.16309   1.000 28.31330  ? 80  GLU G CD  1 
ATOM   3824 O  OE1 . GLU D 1 44  ? 10.63965  1.35831   9.15285   1.000 26.26998  ? 80  GLU G OE1 1 
ATOM   3825 O  OE2 . GLU D 1 44  ? 12.51646  2.32714   8.55242   1.000 32.96681  ? 80  GLU G OE2 1 
ATOM   3826 N  N   . TYR D 1 45  ? 11.14040  -3.76714  11.21947  1.000 16.40366  ? 81  TYR G N   1 
ATOM   3827 C  CA  . TYR D 1 45  ? 10.20380  -4.72677  11.81095  1.000 16.66382  ? 81  TYR G CA  1 
ATOM   3828 C  C   . TYR D 1 45  ? 10.77273  -5.32883  13.09281  1.000 16.79592  ? 81  TYR G C   1 
ATOM   3829 O  O   . TYR D 1 45  ? 10.09749  -5.36515  14.13787  1.000 18.46248  ? 81  TYR G O   1 
ATOM   3830 C  CB  . TYR D 1 45  ? 9.85193   -5.84707  10.81833  1.000 16.52862  ? 81  TYR G CB  1 
ATOM   3831 C  CG  . TYR D 1 45  ? 8.87756   -6.81792  11.45901  1.000 15.95311  ? 81  TYR G CG  1 
ATOM   3832 C  CD1 . TYR D 1 45  ? 9.34164   -7.90147  12.21416  1.000 16.59637  ? 81  TYR G CD1 1 
ATOM   3833 C  CD2 . TYR D 1 45  ? 7.50518   -6.62406  11.36096  1.000 19.53732  ? 81  TYR G CD2 1 
ATOM   3834 C  CE1 . TYR D 1 45  ? 8.45865   -8.77954  12.83998  1.000 17.52211  ? 81  TYR G CE1 1 
ATOM   3835 C  CE2 . TYR D 1 45  ? 6.60782   -7.50106  11.99202  1.000 21.00977  ? 81  TYR G CE2 1 
ATOM   3836 C  CZ  . TYR D 1 45  ? 7.09793   -8.57588  12.72367  1.000 19.86660  ? 81  TYR G CZ  1 
ATOM   3837 O  OH  . TYR D 1 45  ? 6.24385   -9.46029  13.35430  1.000 21.17082  ? 81  TYR G OH  1 
ATOM   3838 N  N   . CYS D 1 46  ? 12.01771  -5.81371  13.03875  1.000 16.76542  ? 82  CYS G N   1 
ATOM   3839 C  CA  . CYS D 1 46  ? 12.58559  -6.43915  14.22699  1.000 15.32486  ? 82  CYS G CA  1 
ATOM   3840 C  C   . CYS D 1 46  ? 12.63229  -5.44702  15.37481  1.000 16.31940  ? 82  CYS G C   1 
ATOM   3841 O  O   . CYS D 1 46  ? 12.37015  -5.81248  16.52649  1.000 17.99492  ? 82  CYS G O   1 
ATOM   3842 C  CB  . CYS D 1 46  ? 13.99736  -6.94412  13.95829  1.000 17.57026  ? 82  CYS G CB  1 
ATOM   3843 S  SG  . CYS D 1 46  ? 14.04945  -8.17610  12.63170  1.000 17.98111  ? 82  CYS G SG  1 
ATOM   3844 N  N   . LEU D 1 47  ? 12.99094  -4.19766  15.06941  1.000 16.13335  ? 83  LEU G N   1 
ATOM   3845 C  CA  . LEU D 1 47  ? 13.06544  -3.17439  16.10909  1.000 18.85709  ? 83  LEU G CA  1 
ATOM   3846 C  C   . LEU D 1 47  ? 11.68873  -2.91234  16.68814  1.000 19.46737  ? 83  LEU G C   1 
ATOM   3847 O  O   . LEU D 1 47  ? 11.53535  -2.81275  17.90709  1.000 24.97412  ? 83  LEU G O   1 
ATOM   3848 C  CB  . LEU D 1 47  ? 13.65907  -1.87873  15.55010  1.000 20.39404  ? 83  LEU G CB  1 
ATOM   3849 C  CG  . LEU D 1 47  ? 15.11611  -1.91873  15.06388  1.000 18.91932  ? 83  LEU G CG  1 
ATOM   3850 C  CD1 . LEU D 1 47  ? 15.46474  -0.62924  14.29264  1.000 18.87297  ? 83  LEU G CD1 1 
ATOM   3851 C  CD2 . LEU D 1 47  ? 16.09768  -2.14765  16.21744  1.000 19.45069  ? 83  LEU G CD2 1 
ATOM   3852 N  N   . GLN D 1 48  ? 10.66467  -2.83114  15.83499  1.000 19.89625  ? 84  GLN G N   1 
ATOM   3853 C  CA  . GLN D 1 48  ? 9.35981   -2.52691  16.40298  1.000 24.53067  ? 84  GLN G CA  1 
ATOM   3854 C  C   . GLN D 1 48  ? 8.79049   -3.70065  17.18113  1.000 33.10657  ? 84  GLN G C   1 
ATOM   3855 O  O   . GLN D 1 48  ? 7.83888   -3.50602  17.94308  1.000 26.91117  ? 84  GLN G O   1 
ATOM   3856 C  CB  . GLN D 1 48  ? 8.37185   -2.03309  15.33583  1.000 32.02672  ? 84  GLN G CB  1 
ATOM   3857 C  CG  . GLN D 1 48  ? 7.50118   -3.05967  14.64205  1.000 47.49940  ? 84  GLN G CG  1 
ATOM   3858 C  CD  . GLN D 1 48  ? 6.81834   -2.47074  13.41090  1.000 55.43554  ? 84  GLN G CD  1 
ATOM   3859 O  OE1 . GLN D 1 48  ? 6.96462   -1.27766  13.12676  1.000 68.22530  ? 84  GLN G OE1 1 
ATOM   3860 N  NE2 . GLN D 1 48  ? 6.04529   -3.29127  12.69682  1.000 35.77777  ? 84  GLN G NE2 1 
ATOM   3861 N  N   . GLU D 1 49  ? 9.37847   -4.89370  17.07311  1.000 22.05218  ? 85  GLU G N   1 
ATOM   3862 C  CA  . GLU D 1 49  ? 8.99659   -5.96939  17.97783  1.000 23.01199  ? 85  GLU G CA  1 
ATOM   3863 C  C   . GLU D 1 49  ? 9.89734   -6.05907  19.19635  1.000 19.22540  ? 85  GLU G C   1 
ATOM   3864 O  O   . GLU D 1 49  ? 9.80697   -7.04474  19.93679  1.000 25.04153  ? 85  GLU G O   1 
ATOM   3865 C  CB  . GLU D 1 49  ? 8.97550   -7.31796  17.24832  1.000 20.25818  ? 85  GLU G CB  1 
ATOM   3866 C  CG  . GLU D 1 49  ? 8.08035   -7.27774  16.02123  1.000 23.98459  ? 85  GLU G CG  1 
ATOM   3867 C  CD  . GLU D 1 49  ? 6.61005   -7.17735  16.40239  1.000 35.76666  ? 85  GLU G CD  1 
ATOM   3868 O  OE1 . GLU D 1 49  ? 6.17191   -7.98410  17.24194  1.000 33.51516  ? 85  GLU G OE1 1 
ATOM   3869 O  OE2 . GLU D 1 49  ? 5.90532   -6.27520  15.88653  1.000 33.33090  ? 85  GLU G OE2 1 
ATOM   3870 N  N   . GLY D 1 50  ? 10.75189  -5.05735  19.42392  1.000 21.97408  ? 86  GLY G N   1 
ATOM   3871 C  CA  . GLY D 1 50  ? 11.67287  -5.08423  20.54637  1.000 19.89353  ? 86  GLY G CA  1 
ATOM   3872 C  C   . GLY D 1 50  ? 12.85753  -6.00285  20.35535  1.000 27.53002  ? 86  GLY G C   1 
ATOM   3873 O  O   . GLY D 1 50  ? 13.44208  -6.47708  21.33584  1.000 23.61170  ? 86  GLY G O   1 
ATOM   3874 N  N   . ALA D 1 51  ? 13.23219  -6.26836  19.11076  1.000 19.14323  ? 87  ALA G N   1 
ATOM   3875 C  CA  . ALA D 1 51  ? 14.33169  -7.17348  18.81488  1.000 16.11905  ? 87  ALA G CA  1 
ATOM   3876 C  C   . ALA D 1 51  ? 15.25692  -6.44063  17.84508  1.000 16.87447  ? 87  ALA G C   1 
ATOM   3877 O  O   . ALA D 1 51  ? 15.28363  -5.20663  17.76801  1.000 16.39576  ? 87  ALA G O   1 
ATOM   3878 C  CB  . ALA D 1 51  ? 13.77838  -8.50113  18.27091  1.000 17.85588  ? 87  ALA G CB  1 
ATOM   3879 N  N   . ASP D 1 52  ? 16.05302  -7.19670  17.10083  1.000 16.14186  ? 88  ASP G N   1 
ATOM   3880 C  CA  . ASP D 1 52  ? 16.84978  -6.62314  16.01882  1.000 15.16819  ? 88  ASP G CA  1 
ATOM   3881 C  C   . ASP D 1 52  ? 17.10167  -7.76139  15.03697  1.000 16.14718  ? 88  ASP G C   1 
ATOM   3882 O  O   . ASP D 1 52  ? 16.67040  -8.88879  15.26897  1.000 14.86592  ? 88  ASP G O   1 
ATOM   3883 C  CB  . ASP D 1 52  ? 18.15283  -6.00312  16.55249  1.000 16.13132  ? 88  ASP G CB  1 
ATOM   3884 C  CG  . ASP D 1 52  ? 18.67594  -4.86111  15.67560  1.000 22.20929  ? 88  ASP G CG  1 
ATOM   3885 O  OD1 . ASP D 1 52  ? 18.41365  -4.85386  14.44995  1.000 17.81761  ? 88  ASP G OD1 1 
ATOM   3886 O  OD2 . ASP D 1 52  ? 19.36602  -3.96938  16.22693  1.000 20.32411  ? 88  ASP G OD2 1 
ATOM   3887 N  N   . LEU D 1 53  ? 17.75079  -7.46463  13.90822  1.000 15.05548  ? 89  LEU G N   1 
ATOM   3888 C  CA  . LEU D 1 53  ? 18.08689  -8.55672  12.99624  1.000 14.87197  ? 89  LEU G CA  1 
ATOM   3889 C  C   . LEU D 1 53  ? 19.05987  -9.52734  13.65891  1.000 13.85530  ? 89  LEU G C   1 
ATOM   3890 O  O   . LEU D 1 53  ? 19.78379  -9.18066  14.59861  1.000 15.45618  ? 89  LEU G O   1 
ATOM   3891 C  CB  . LEU D 1 53  ? 18.68519  -8.00904  11.69088  1.000 12.25648  ? 89  LEU G CB  1 
ATOM   3892 C  CG  . LEU D 1 53  ? 17.68408  -7.38268  10.71268  1.000 14.15960  ? 89  LEU G CG  1 
ATOM   3893 C  CD1 . LEU D 1 53  ? 18.43614  -6.61248  9.63375   1.000 16.69420  ? 89  LEU G CD1 1 
ATOM   3894 C  CD2 . LEU D 1 53  ? 16.81308  -8.50250  10.06446  1.000 14.05020  ? 89  LEU G CD2 1 
ATOM   3895 N  N   . ALA D 1 54  ? 19.04104  -10.77604 13.18428  1.000 13.59932  ? 90  ALA G N   1 
ATOM   3896 C  CA  . ALA D 1 54  ? 19.79592  -11.83971 13.84759  1.000 12.67212  ? 90  ALA G CA  1 
ATOM   3897 C  C   . ALA D 1 54  ? 21.29796  -11.58343 13.81473  1.000 13.12304  ? 90  ALA G C   1 
ATOM   3898 O  O   . ALA D 1 54  ? 21.84788  -11.10685 12.81857  1.000 14.75785  ? 90  ALA G O   1 
ATOM   3899 C  CB  . ALA D 1 54  ? 19.48148  -13.19342 13.18759  1.000 14.42582  ? 90  ALA G CB  1 
ATOM   3900 N  N   . ILE D 1 55  ? 21.96069  -11.91654 14.92624  1.000 15.25424  ? 91  ILE G N   1 
ATOM   3901 C  CA  . ILE D 1 55  ? 23.39546  -11.71653 15.11164  1.000 15.28212  ? 91  ILE G CA  1 
ATOM   3902 C  C   . ILE D 1 55  ? 24.02077  -13.09005 15.32245  1.000 13.00068  ? 91  ILE G C   1 
ATOM   3903 O  O   . ILE D 1 55  ? 23.63894  -13.82477 16.24587  1.000 15.37967  ? 91  ILE G O   1 
ATOM   3904 C  CB  . ILE D 1 55  ? 23.69491  -10.77962 16.29910  1.000 14.73247  ? 91  ILE G CB  1 
ATOM   3905 C  CG1 . ILE D 1 55  ? 23.14870  -9.36877  16.01566  1.000 16.82636  ? 91  ILE G CG1 1 
ATOM   3906 C  CG2 . ILE D 1 55  ? 25.20990  -10.73627 16.55688  1.000 18.42944  ? 91  ILE G CG2 1 
ATOM   3907 C  CD1 . ILE D 1 55  ? 23.14641  -8.44432  17.25034  1.000 19.08150  ? 91  ILE G CD1 1 
ATOM   3908 N  N   . ILE D 1 56  ? 24.96134  -13.45487 14.46375  1.000 15.00123  ? 92  ILE G N   1 
ATOM   3909 C  CA  . ILE D 1 56  ? 25.51759  -14.80201 14.48707  1.000 15.65317  ? 92  ILE G CA  1 
ATOM   3910 C  C   . ILE D 1 56  ? 26.78041  -14.77443 15.34209  1.000 17.45030  ? 92  ILE G C   1 
ATOM   3911 O  O   . ILE D 1 56  ? 27.80742  -14.23652 14.92172  1.000 19.94249  ? 92  ILE G O   1 
ATOM   3912 C  CB  . ILE D 1 56  ? 25.81546  -15.31570 13.07639  1.000 17.33928  ? 92  ILE G CB  1 
ATOM   3913 C  CG1 . ILE D 1 56  ? 24.57230  -15.15507 12.18801  1.000 16.92088  ? 92  ILE G CG1 1 
ATOM   3914 C  CG2 . ILE D 1 56  ? 26.26376  -16.79235 13.17201  1.000 18.51750  ? 92  ILE G CG2 1 
ATOM   3915 C  CD1 . ILE D 1 56  ? 23.34635  -15.90819 12.70345  1.000 18.05639  ? 92  ILE G CD1 1 
ATOM   3916 N  N   . ASN D 1 57  ? 26.70305  -15.37639 16.53268  1.000 17.29655  ? 93  ASN G N   1 
ATOM   3917 C  CA  . ASN D 1 57  ? 27.76734  -15.31612 17.52884  1.000 21.79362  ? 93  ASN G CA  1 
ATOM   3918 C  C   . ASN D 1 57  ? 28.57722  -16.59823 17.64091  1.000 26.46889  ? 93  ASN G C   1 
ATOM   3919 O  O   . ASN D 1 57  ? 29.53882  -16.63338 18.42023  1.000 25.60880  ? 93  ASN G O   1 
ATOM   3920 C  CB  . ASN D 1 57  ? 27.18633  -15.01272 18.91015  1.000 21.70647  ? 93  ASN G CB  1 
ATOM   3921 C  CG  . ASN D 1 57  ? 26.40862  -13.72511 18.95233  1.000 26.47457  ? 93  ASN G CG  1 
ATOM   3922 O  OD1 . ASN D 1 57  ? 25.18497  -13.73366 18.83057  1.000 19.78628  ? 93  ASN G OD1 1 
ATOM   3923 N  ND2 . ASN D 1 57  ? 27.10171  -12.61141 19.16977  1.000 23.24686  ? 93  ASN G ND2 1 
ATOM   3924 N  N   . SER D 1 58  ? 28.20006  -17.66225 16.93331  1.000 19.60027  ? 94  SER G N   1 
ATOM   3925 C  CA  . SER D 1 58  ? 28.86538  -18.95158 17.10630  1.000 18.78592  ? 94  SER G CA  1 
ATOM   3926 C  C   . SER D 1 58  ? 28.61452  -19.82638 15.88797  1.000 20.72736  ? 94  SER G C   1 
ATOM   3927 O  O   . SER D 1 58  ? 27.68365  -19.59977 15.11360  1.000 19.95778  ? 94  SER G O   1 
ATOM   3928 C  CB  . SER D 1 58  ? 28.38000  -19.66820 18.37558  1.000 21.26740  ? 94  SER G CB  1 
ATOM   3929 O  OG  . SER D 1 58  ? 27.04781  -20.15238 18.20260  1.000 21.24994  ? 94  SER G OG  1 
ATOM   3930 N  N   . ARG D 1 59  ? 29.45834  -20.84631 15.73266  1.000 19.04895  ? 95  ARG G N   1 
ATOM   3931 C  CA  . ARG D 1 59  ? 29.26527  -21.77636 14.63208  1.000 21.22645  ? 95  ARG G CA  1 
ATOM   3932 C  C   . ARG D 1 59  ? 27.95941  -22.54298 14.78945  1.000 17.58717  ? 95  ARG G C   1 
ATOM   3933 O  O   . ARG D 1 59  ? 27.28864  -22.83686 13.79584  1.000 20.72366  ? 95  ARG G O   1 
ATOM   3934 C  CB  . ARG D 1 59  ? 30.45220  -22.72844 14.58520  1.000 29.54185  ? 95  ARG G CB  1 
ATOM   3935 C  CG  . ARG D 1 59  ? 30.35646  -23.87084 13.63322  1.000 35.62138  ? 95  ARG G CG  1 
ATOM   3936 C  CD  . ARG D 1 59  ? 31.70863  -24.60580 13.47274  1.000 36.81199  ? 95  ARG G CD  1 
ATOM   3937 N  NE  . ARG D 1 59  ? 32.82528  -23.81635 12.94313  1.000 58.81598  ? 95  ARG G NE  1 
ATOM   3938 C  CZ  . ARG D 1 59  ? 33.48592  -22.84164 13.56431  1.000 66.07586  ? 95  ARG G CZ  1 
ATOM   3939 N  NH1 . ARG D 1 59  ? 33.36517  -22.63290 14.86920  1.000 66.06826  ? 95  ARG G NH1 1 
ATOM   3940 N  NH2 . ARG D 1 59  ? 34.32996  -22.08654 12.86518  1.000 61.42093  ? 95  ARG G NH2 1 
ATOM   3941 N  N   . ALA D 1 60  ? 27.57156  -22.85943 16.02805  1.000 19.97908  ? 96  ALA G N   1 
ATOM   3942 C  CA  . ALA D 1 60  ? 26.28948  -23.52727 16.24533  1.000 19.78115  ? 96  ALA G CA  1 
ATOM   3943 C  C   . ALA D 1 60  ? 25.13553  -22.65629 15.76960  1.000 19.77621  ? 96  ALA G C   1 
ATOM   3944 O  O   . ALA D 1 60  ? 24.16658  -23.15783 15.18115  1.000 17.69658  ? 96  ALA G O   1 
ATOM   3945 C  CB  . ALA D 1 60  ? 26.12675  -23.88425 17.72898  1.000 25.49147  ? 96  ALA G CB  1 
ATOM   3946 N  N   . GLU D 1 61  ? 25.23683  -21.34055 15.98615  1.000 16.33630  ? 97  GLU G N   1 
ATOM   3947 C  CA  . GLU D 1 61  ? 24.14601  -20.46112 15.59142  1.000 16.95574  ? 97  GLU G CA  1 
ATOM   3948 C  C   . GLU D 1 61  ? 24.11164  -20.30971 14.07087  1.000 15.34663  ? 97  GLU G C   1 
ATOM   3949 O  O   . GLU D 1 61  ? 23.02813  -20.23381 13.46666  1.000 15.87672  ? 97  GLU G O   1 
ATOM   3950 C  CB  . GLU D 1 61  ? 24.28190  -19.11356 16.31469  1.000 19.68353  ? 97  GLU G CB  1 
ATOM   3951 C  CG  . GLU D 1 61  ? 23.11581  -18.14766 16.06215  1.000 17.65964  ? 97  GLU G CG  1 
ATOM   3952 C  CD  . GLU D 1 61  ? 23.15273  -16.92425 16.94817  1.000 22.03007  ? 97  GLU G CD  1 
ATOM   3953 O  OE1 . GLU D 1 61  ? 24.26763  -16.54491 17.38525  1.000 19.01367  ? 97  GLU G OE1 1 
ATOM   3954 O  OE2 . GLU D 1 61  ? 22.05792  -16.35339 17.21370  1.000 17.60468  ? 97  GLU G OE2 1 
ATOM   3955 N  N   . GLN D 1 62  ? 25.29030  -20.29504 13.42750  1.000 16.00945  ? 98  GLN G N   1 
ATOM   3956 C  CA  . GLN D 1 62  ? 25.32675  -20.29528 11.96722  1.000 15.42783  ? 98  GLN G CA  1 
ATOM   3957 C  C   . GLN D 1 62  ? 24.71414  -21.57356 11.40059  1.000 17.33645  ? 98  GLN G C   1 
ATOM   3958 O  O   . GLN D 1 62  ? 23.97862  -21.53370 10.40187  1.000 16.66781  ? 98  GLN G O   1 
ATOM   3959 C  CB  . GLN D 1 62  ? 26.76971  -20.14368 11.47127  1.000 14.32565  ? 98  GLN G CB  1 
ATOM   3960 C  CG  . GLN D 1 62  ? 26.89227  -20.22900 9.95254   1.000 15.88645  ? 98  GLN G CG  1 
ATOM   3961 C  CD  . GLN D 1 62  ? 26.28496  -19.01042 9.21401   1.000 15.31407  ? 98  GLN G CD  1 
ATOM   3962 O  OE1 . GLN D 1 62  ? 26.06913  -17.93815 9.79536   1.000 16.11045  ? 98  GLN G OE1 1 
ATOM   3963 N  NE2 . GLN D 1 62  ? 26.01101  -19.19133 7.93321   1.000 15.83769  ? 98  GLN G NE2 1 
ATOM   3964 N  N   . ALA D 1 63  ? 25.04164  -22.72783 11.99898  1.000 16.34128  ? 99  ALA G N   1 
ATOM   3965 C  CA  . ALA D 1 63  ? 24.48188  -23.99211 11.52059  1.000 15.60503  ? 99  ALA G CA  1 
ATOM   3966 C  C   . ALA D 1 63  ? 22.96250  -24.00008 11.67316  1.000 15.63407  ? 99  ALA G C   1 
ATOM   3967 O  O   . ALA D 1 63  ? 22.23754  -24.48041 10.79377  1.000 17.80073  ? 99  ALA G O   1 
ATOM   3968 C  CB  . ALA D 1 63  ? 25.11317  -25.16605 12.28607  1.000 18.23682  ? 99  ALA G CB  1 
ATOM   3969 N  N   . PHE D 1 64  ? 22.46999  -23.46943 12.79262  1.000 14.77054  ? 100 PHE G N   1 
ATOM   3970 C  CA  . PHE D 1 64  ? 21.03250  -23.31390 13.01198  1.000 16.61274  ? 100 PHE G CA  1 
ATOM   3971 C  C   . PHE D 1 64  ? 20.41349  -22.43995 11.91747  1.000 14.80873  ? 100 PHE G C   1 
ATOM   3972 O  O   . PHE D 1 64  ? 19.39524  -22.79967 11.31240  1.000 14.24186  ? 100 PHE G O   1 
ATOM   3973 C  CB  . PHE D 1 64  ? 20.85771  -22.73346 14.43272  1.000 15.60334  ? 100 PHE G CB  1 
ATOM   3974 C  CG  . PHE D 1 64  ? 19.51050  -22.09785 14.75175  1.000 16.28940  ? 100 PHE G CG  1 
ATOM   3975 C  CD1 . PHE D 1 64  ? 18.41082  -22.88846 15.09443  1.000 16.42613  ? 100 PHE G CD1 1 
ATOM   3976 C  CD2 . PHE D 1 64  ? 19.38849  -20.70463 14.81893  1.000 15.37523  ? 100 PHE G CD2 1 
ATOM   3977 C  CE1 . PHE D 1 64  ? 17.19924  -22.29650 15.47163  1.000 15.93947  ? 100 PHE G CE1 1 
ATOM   3978 C  CE2 . PHE D 1 64  ? 18.17290  -20.08681 15.17789  1.000 18.96909  ? 100 PHE G CE2 1 
ATOM   3979 C  CZ  . PHE D 1 64  ? 17.07013  -20.89366 15.50505  1.000 19.41075  ? 100 PHE G CZ  1 
ATOM   3980 N  N   . LEU D 1 65  ? 21.04747  -21.30242 11.62352  1.000 13.18777  ? 101 LEU G N   1 
ATOM   3981 C  CA  . LEU D 1 65  ? 20.57150  -20.42670 10.55179  1.000 14.12632  ? 101 LEU G CA  1 
ATOM   3982 C  C   . LEU D 1 65  ? 20.54524  -21.16212 9.21999   1.000 15.35303  ? 101 LEU G C   1 
ATOM   3983 O  O   . LEU D 1 65  ? 19.57495  -21.06049 8.44947   1.000 15.38632  ? 101 LEU G O   1 
ATOM   3984 C  CB  . LEU D 1 65  ? 21.48200  -19.18958 10.47037  1.000 14.00477  ? 101 LEU G CB  1 
ATOM   3985 C  CG  . LEU D 1 65  ? 21.35532  -18.30962 9.22044   1.000 14.27624  ? 101 LEU G CG  1 
ATOM   3986 C  CD1 . LEU D 1 65  ? 20.01831  -17.54404 9.23287   1.000 16.84880  ? 101 LEU G CD1 1 
ATOM   3987 C  CD2 . LEU D 1 65  ? 22.54139  -17.31874 9.12351   1.000 15.25521  ? 101 LEU G CD2 1 
ATOM   3988 N  N   . GLU D 1 66  ? 21.63168  -21.88115 8.90475   1.000 15.16825  ? 102 GLU G N   1 
ATOM   3989 C  CA  . GLU D 1 66  ? 21.70550  -22.55157 7.60274   1.000 12.82038  ? 102 GLU G CA  1 
ATOM   3990 C  C   . GLU D 1 66  ? 20.68111  -23.66287 7.45404   1.000 16.76171  ? 102 GLU G C   1 
ATOM   3991 O  O   . GLU D 1 66  ? 20.21145  -23.93794 6.33454   1.000 16.06301  ? 102 GLU G O   1 
ATOM   3992 C  CB  . GLU D 1 66  ? 23.12810  -23.09759 7.37105   1.000 16.83440  ? 102 GLU G CB  1 
ATOM   3993 C  CG  . GLU D 1 66  ? 24.11078  -21.95498 7.19848   1.000 23.33875  ? 102 GLU G CG  1 
ATOM   3994 C  CD  . GLU D 1 66  ? 25.51288  -22.41543 6.85116   1.000 42.59134  ? 102 GLU G CD  1 
ATOM   3995 O  OE1 . GLU D 1 66  ? 25.82779  -23.58765 7.15621   1.000 36.40042  ? 102 GLU G OE1 1 
ATOM   3996 O  OE2 . GLU D 1 66  ? 26.26995  -21.61188 6.24129   1.000 36.28588  ? 102 GLU G OE2 1 
ATOM   3997 N  N   . ASN D 1 67  ? 20.29918  -24.29597 8.55193   1.000 14.50420  ? 103 ASN G N   1 
ATOM   3998 C  CA  . ASN D 1 67  ? 19.43041  -25.46125 8.43807   1.000 17.45360  ? 103 ASN G CA  1 
ATOM   3999 C  C   . ASN D 1 67  ? 17.98869  -25.09058 8.07767   1.000 14.38595  ? 103 ASN G C   1 
ATOM   4000 O  O   . ASN D 1 67  ? 17.17644  -25.97748 7.76159   1.000 16.32769  ? 103 ASN G O   1 
ATOM   4001 C  CB  . ASN D 1 67  ? 19.49848  -26.24593 9.75187   1.000 16.01117  ? 103 ASN G CB  1 
ATOM   4002 C  CG  . ASN D 1 67  ? 18.85426  -27.61213 9.63318   1.000 20.25079  ? 103 ASN G CG  1 
ATOM   4003 O  OD1 . ASN D 1 67  ? 19.10357  -28.33293 8.65415   1.000 21.28649  ? 103 ASN G OD1 1 
ATOM   4004 N  ND2 . ASN D 1 67  ? 18.02191  -27.97181 10.60840  1.000 19.22384  ? 103 ASN G ND2 1 
ATOM   4005 N  N   . PHE D 1 68  ? 17.64398  -23.80227 8.09612   1.000 14.60877  ? 104 PHE G N   1 
ATOM   4006 C  CA  . PHE D 1 68  ? 16.32117  -23.40668 7.62425   1.000 14.71194  ? 104 PHE G CA  1 
ATOM   4007 C  C   . PHE D 1 68  ? 16.24910  -23.35679 6.09955   1.000 12.42995  ? 104 PHE G C   1 
ATOM   4008 O  O   . PHE D 1 68  ? 15.15699  -23.16548 5.55199   1.000 13.96566  ? 104 PHE G O   1 
ATOM   4009 C  CB  . PHE D 1 68  ? 15.93921  -22.05528 8.25081   1.000 14.34986  ? 104 PHE G CB  1 
ATOM   4010 C  CG  . PHE D 1 68  ? 15.68710  -22.15769 9.73845   1.000 15.36482  ? 104 PHE G CG  1 
ATOM   4011 C  CD1 . PHE D 1 68  ? 14.67253  -22.98783 10.21224  1.000 13.73077  ? 104 PHE G CD1 1 
ATOM   4012 C  CD2 . PHE D 1 68  ? 16.49776  -21.48958 10.63933  1.000 13.79386  ? 104 PHE G CD2 1 
ATOM   4013 C  CE1 . PHE D 1 68  ? 14.45363  -23.14744 11.58433  1.000 16.80747  ? 104 PHE G CE1 1 
ATOM   4014 C  CE2 . PHE D 1 68  ? 16.29136  -21.63376 12.01832  1.000 14.36361  ? 104 PHE G CE2 1 
ATOM   4015 C  CZ  . PHE D 1 68  ? 15.26247  -22.44871 12.48776  1.000 16.23306  ? 104 PHE G CZ  1 
ATOM   4016 N  N   . LYS D 1 69  ? 17.38628  -23.51555 5.40492   1.000 15.12101  ? 105 LYS G N   1 
ATOM   4017 C  CA  . LYS D 1 69  ? 17.38639  -23.67206 3.94271   1.000 16.13531  ? 105 LYS G CA  1 
ATOM   4018 C  C   . LYS D 1 69  ? 16.69954  -22.49102 3.26881   1.000 16.86630  ? 105 LYS G C   1 
ATOM   4019 O  O   . LYS D 1 69  ? 15.87777  -22.64071 2.35614   1.000 16.41373  ? 105 LYS G O   1 
ATOM   4020 C  CB  . LYS D 1 69  ? 16.73542  -25.00023 3.54256   1.000 14.98822  ? 105 LYS G CB  1 
ATOM   4021 C  CG  . LYS D 1 69  ? 17.33813  -26.16343 4.33962   1.000 23.31168  ? 105 LYS G CG  1 
ATOM   4022 C  CD  . LYS D 1 69  ? 16.73655  -27.51848 3.95848   1.000 26.04670  ? 105 LYS G CD  1 
ATOM   4023 C  CE  . LYS D 1 69  ? 16.44036  -28.37107 5.19234   1.000 20.81705  ? 105 LYS G CE  1 
ATOM   4024 N  NZ  . LYS D 1 69  ? 17.58377  -28.37345 6.14668   1.000 18.71536  ? 105 LYS G NZ  1 
ATOM   4025 N  N   . MET D 1 70  ? 17.02225  -21.29749 3.74287   1.000 14.47949  ? 106 MET G N   1 
ATOM   4026 C  CA  . MET D 1 70  ? 16.25825  -20.12030 3.36690   1.000 13.58947  ? 106 MET G CA  1 
ATOM   4027 C  C   . MET D 1 70  ? 17.20235  -18.94544 3.21017   1.000 12.17044  ? 106 MET G C   1 
ATOM   4028 O  O   . MET D 1 70  ? 18.07673  -18.73781 4.05246   1.000 15.77992  ? 106 MET G O   1 
ATOM   4029 C  CB  . MET D 1 70  ? 15.23247  -19.81278 4.47175   1.000 18.95440  ? 106 MET G CB  1 
ATOM   4030 C  CG  . MET D 1 70  ? 14.20050  -18.79539 4.13295   1.000 22.76320  ? 106 MET G CG  1 
ATOM   4031 S  SD  . MET D 1 70  ? 13.19761  -18.54570 5.62798   1.000 23.33305  ? 106 MET G SD  1 
ATOM   4032 C  CE  . MET D 1 70  ? 12.25202  -20.08695 5.72501   1.000 21.21638  ? 106 MET G CE  1 
ATOM   4033 N  N   . THR D 1 71  ? 17.01312  -18.15404 2.15722   1.000 12.08469  ? 107 THR G N   1 
ATOM   4034 C  CA  . THR D 1 71  ? 17.80678  -16.93792 2.02228   1.000 11.46056  ? 107 THR G CA  1 
ATOM   4035 C  C   . THR D 1 71  ? 17.22606  -15.87703 2.94476   1.000 12.31575  ? 107 THR G C   1 
ATOM   4036 O  O   . THR D 1 71  ? 16.02063  -15.59198 2.88456   1.000 15.68127  ? 107 THR G O   1 
ATOM   4037 C  CB  . THR D 1 71  ? 17.77911  -16.47780 0.56342   1.000 14.11083  ? 107 THR G CB  1 
ATOM   4038 O  OG1 . THR D 1 71  ? 18.43357  -17.48729 -0.21596  1.000 17.43579  ? 107 THR G OG1 1 
ATOM   4039 C  CG2 . THR D 1 71  ? 18.52587  -15.14440 0.38240   1.000 14.44084  ? 107 THR G CG2 1 
ATOM   4040 N  N   . LEU D 1 72  ? 18.07594  -15.28584 3.80465   1.000 13.20416  ? 108 LEU G N   1 
ATOM   4041 C  CA  . LEU D 1 72  ? 17.59010  -14.43514 4.88115   1.000 11.56167  ? 108 LEU G CA  1 
ATOM   4042 C  C   . LEU D 1 72  ? 18.50811  -13.23888 5.08554   1.000 12.53406  ? 108 LEU G C   1 
ATOM   4043 O  O   . LEU D 1 72  ? 19.72568  -13.40780 5.15528   1.000 13.59359  ? 108 LEU G O   1 
ATOM   4044 C  CB  . LEU D 1 72  ? 17.55268  -15.18607 6.22202   1.000 12.76995  ? 108 LEU G CB  1 
ATOM   4045 C  CG  . LEU D 1 72  ? 16.43023  -16.20704 6.36988   1.000 10.70176  ? 108 LEU G CG  1 
ATOM   4046 C  CD1 . LEU D 1 72  ? 16.83546  -17.26128 7.42156   1.000 13.85993  ? 108 LEU G CD1 1 
ATOM   4047 C  CD2 . LEU D 1 72  ? 15.11908  -15.51790 6.76809   1.000 11.62259  ? 108 LEU G CD2 1 
ATOM   4048 N  N   . TRP D 1 73  ? 17.92199  -12.05167 5.25272   1.000 12.34082  ? 109 TRP G N   1 
ATOM   4049 C  CA  . TRP D 1 73  ? 18.69334  -10.93227 5.79802   1.000 12.88801  ? 109 TRP G CA  1 
ATOM   4050 C  C   . TRP D 1 73  ? 19.10204  -11.22374 7.23659   1.000 14.12001  ? 109 TRP G C   1 
ATOM   4051 O  O   . TRP D 1 73  ? 18.29148  -11.69369 8.03766   1.000 14.05516  ? 109 TRP G O   1 
ATOM   4052 C  CB  . TRP D 1 73  ? 17.86075  -9.65156  5.80449   1.000 12.60015  ? 109 TRP G CB  1 
ATOM   4053 C  CG  . TRP D 1 73  ? 17.61269  -8.95232  4.49059   1.000 13.27881  ? 109 TRP G CG  1 
ATOM   4054 C  CD1 . TRP D 1 73  ? 16.39169  -8.46953  4.04676   1.000 12.59095  ? 109 TRP G CD1 1 
ATOM   4055 C  CD2 . TRP D 1 73  ? 18.58926  -8.50661  3.52081   1.000 14.77594  ? 109 TRP G CD2 1 
ATOM   4056 N  NE1 . TRP D 1 73  ? 16.55839  -7.80528  2.85769   1.000 13.13515  ? 109 TRP G NE1 1 
ATOM   4057 C  CE2 . TRP D 1 73  ? 17.88520  -7.81070  2.51066   1.000 15.15108  ? 109 TRP G CE2 1 
ATOM   4058 C  CE3 . TRP D 1 73  ? 19.97924  -8.66585  3.38955   1.000 15.43623  ? 109 TRP G CE3 1 
ATOM   4059 C  CZ2 . TRP D 1 73  ? 18.52905  -7.23786  1.39236   1.000 12.97063  ? 109 TRP G CZ2 1 
ATOM   4060 C  CZ3 . TRP D 1 73  ? 20.62738  -8.08922  2.27188   1.000 16.76361  ? 109 TRP G CZ3 1 
ATOM   4061 C  CH2 . TRP D 1 73  ? 19.89920  -7.38043  1.29819   1.000 12.74628  ? 109 TRP G CH2 1 
ATOM   4062 N  N   . ILE D 1 74  ? 20.35658  -10.92284 7.57040   1.000 11.72828  ? 110 ILE G N   1 
ATOM   4063 C  CA  . ILE D 1 74  ? 20.82734  -11.00036 8.94867   1.000 12.03159  ? 110 ILE G CA  1 
ATOM   4064 C  C   . ILE D 1 74  ? 21.42000  -9.64118  9.34583   1.000 13.54369  ? 110 ILE G C   1 
ATOM   4065 O  O   . ILE D 1 74  ? 21.57280  -8.73648  8.52687   1.000 14.26492  ? 110 ILE G O   1 
ATOM   4066 C  CB  . ILE D 1 74  ? 21.82884  -12.15284 9.14608   1.000 12.28557  ? 110 ILE G CB  1 
ATOM   4067 C  CG1 . ILE D 1 74  ? 23.09856  -11.93544 8.29973   1.000 14.34315  ? 110 ILE G CG1 1 
ATOM   4068 C  CG2 . ILE D 1 74  ? 21.11577  -13.48521 8.81305   1.000 14.12137  ? 110 ILE G CG2 1 
ATOM   4069 C  CD1 . ILE D 1 74  ? 24.17326  -13.00925 8.56338   1.000 15.13904  ? 110 ILE G CD1 1 
ATOM   4070 N  N   . GLY D 1 75  ? 21.71188  -9.49895  10.63771  1.000 14.49478  ? 111 GLY G N   1 
ATOM   4071 C  CA  . GLY D 1 75  ? 22.02641  -8.19686  11.21733  1.000 16.02787  ? 111 GLY G CA  1 
ATOM   4072 C  C   . GLY D 1 75  ? 23.47371  -7.75773  11.09747  1.000 18.40364  ? 111 GLY G C   1 
ATOM   4073 O  O   . GLY D 1 75  ? 24.05436  -7.29174  12.07369  1.000 17.42923  ? 111 GLY G O   1 
ATOM   4074 N  N   . LEU D 1 76  ? 24.06650  -7.89136  9.91097   1.000 13.96195  ? 112 LEU G N   1 
ATOM   4075 C  CA  . LEU D 1 76  ? 25.45297  -7.49836  9.67105   1.000 12.94722  ? 112 LEU G CA  1 
ATOM   4076 C  C   . LEU D 1 76  ? 25.44482  -6.44429  8.57430   1.000 16.72569  ? 112 LEU G C   1 
ATOM   4077 O  O   . LEU D 1 76  ? 24.80187  -6.64294  7.53873   1.000 14.46064  ? 112 LEU G O   1 
ATOM   4078 C  CB  . LEU D 1 76  ? 26.29350  -8.71871  9.25418   1.000 13.89831  ? 112 LEU G CB  1 
ATOM   4079 C  CG  . LEU D 1 76  ? 27.80946  -8.50828  9.12317   1.000 15.72055  ? 112 LEU G CG  1 
ATOM   4080 C  CD1 . LEU D 1 76  ? 28.43418  -8.09250  10.47297  1.000 15.38898  ? 112 LEU G CD1 1 
ATOM   4081 C  CD2 . LEU D 1 76  ? 28.43554  -9.78563  8.62516   1.000 13.89622  ? 112 LEU G CD2 1 
ATOM   4082 N  N   . MET D 1 77  ? 26.14275  -5.32070  8.78248   1.000 14.66017  ? 113 MET G N   1 
ATOM   4083 C  CA  . MET D 1 77  ? 26.11564  -4.30756  7.74118   1.000 12.71036  ? 113 MET G CA  1 
ATOM   4084 C  C   . MET D 1 77  ? 27.48711  -3.64228  7.66388   1.000 16.38767  ? 113 MET G C   1 
ATOM   4085 O  O   . MET D 1 77  ? 28.23742  -3.60214  8.63548   1.000 16.51639  ? 113 MET G O   1 
ATOM   4086 C  CB  . MET D 1 77  ? 24.96937  -3.29109  7.96749   1.000 21.30611  ? 113 MET G CB  1 
ATOM   4087 C  CG  . MET D 1 77  ? 24.91045  -2.13078  6.94202   1.000 26.52343  ? 113 MET G CG  1 
ATOM   4088 S  SD  . MET D 1 77  ? 23.63582  -0.87793  7.25581   1.000 35.59332  ? 113 MET G SD  1 
ATOM   4089 C  CE  . MET D 1 77  ? 23.59267  -0.05259  5.66456   1.000 33.01572  ? 113 MET G CE  1 
ATOM   4090 N  N   . GLU D 1 78  ? 27.80654  -3.15436  6.48261   1.000 14.54689  ? 114 GLU G N   1 
ATOM   4091 C  CA  . GLU D 1 78  ? 29.07955  -2.47787  6.23995   1.000 15.31639  ? 114 GLU G CA  1 
ATOM   4092 C  C   . GLU D 1 78  ? 29.15209  -1.15161  6.99892   1.000 20.25617  ? 114 GLU G C   1 
ATOM   4093 O  O   . GLU D 1 78  ? 28.15285  -0.44742  7.16459   1.000 20.14957  ? 114 GLU G O   1 
ATOM   4094 C  CB  . GLU D 1 78  ? 29.23480  -2.22537  4.74132   1.000 16.89077  ? 114 GLU G CB  1 
ATOM   4095 C  CG  . GLU D 1 78  ? 30.67312  -1.85362  4.31076   1.000 15.98113  ? 114 GLU G CG  1 
ATOM   4096 C  CD  . GLU D 1 78  ? 30.85313  -1.77511  2.80029   1.000 16.84887  ? 114 GLU G CD  1 
ATOM   4097 O  OE1 . GLU D 1 78  ? 29.87167  -2.02505  2.05842   1.000 19.10013  ? 114 GLU G OE1 1 
ATOM   4098 O  OE2 . GLU D 1 78  ? 31.99968  -1.50640  2.34221   1.000 16.71928  ? 114 GLU G OE2 1 
ATOM   4099 N  N   . GLN D 1 79  ? 30.36273  -0.78464  7.42263   1.000 17.34637  ? 115 GLN G N   1 
ATOM   4100 C  CA  . GLN D 1 79  ? 30.61045  0.55503   7.96156   1.000 19.38994  ? 115 GLN G CA  1 
ATOM   4101 C  C   . GLN D 1 79  ? 30.92566  1.44805   6.77083   1.000 23.60766  ? 115 GLN G C   1 
ATOM   4102 O  O   . GLN D 1 79  ? 32.00303  1.34907   6.17904   1.000 20.82061  ? 115 GLN G O   1 
ATOM   4103 C  CB  . GLN D 1 79  ? 31.74025  0.52591   8.98482   1.000 24.42427  ? 115 GLN G CB  1 
ATOM   4104 C  CG  . GLN D 1 79  ? 31.62029  -0.64193  9.95949   1.000 30.67633  ? 115 GLN G CG  1 
ATOM   4105 C  CD  . GLN D 1 79  ? 32.66572  -0.60584  11.05339  1.000 37.84568  ? 115 GLN G CD  1 
ATOM   4106 O  OE1 . GLN D 1 79  ? 33.64423  -1.35081  11.01342  1.000 33.59641  ? 115 GLN G OE1 1 
ATOM   4107 N  NE2 . GLN D 1 79  ? 32.44937  0.24364   12.05368  1.000 38.64400  ? 115 GLN G NE2 1 
ATOM   4108 N  N   . ARG D 1 80  ? 29.95384  2.27210   6.38114   1.000 20.96729  ? 116 ARG G N   1 
ATOM   4109 C  CA  . ARG D 1 80  ? 30.05918  3.17887   5.23674   1.000 23.75685  ? 116 ARG G CA  1 
ATOM   4110 C  C   . ARG D 1 80  ? 30.48520  2.34799   4.02480   1.000 23.07913  ? 116 ARG G C   1 
ATOM   4111 O  O   . ARG D 1 80  ? 29.83787  1.33022   3.73583   1.000 23.02936  ? 116 ARG G O   1 
ATOM   4112 C  CB  . ARG D 1 80  ? 30.98232  4.33204   5.63014   1.000 22.19561  ? 116 ARG G CB  1 
ATOM   4113 C  CG  . ARG D 1 80  ? 30.31633  5.25941   6.64881   1.000 36.06711  ? 116 ARG G CG  1 
ATOM   4114 C  CD  . ARG D 1 80  ? 31.28565  6.19323   7.37660   1.000 61.65740  ? 116 ARG G CD  1 
ATOM   4115 N  NE  . ARG D 1 80  ? 30.64396  7.45136   7.74912   1.000 82.65357  ? 116 ARG G NE  1 
ATOM   4116 C  CZ  . ARG D 1 80  ? 30.88555  8.11936   8.87094   1.000 88.15617  ? 116 ARG G CZ  1 
ATOM   4117 N  NH1 . ARG D 1 80  ? 31.72340  7.65679   9.78580   1.000 83.56204  ? 116 ARG G NH1 1 
ATOM   4118 N  NH2 . ARG D 1 80  ? 30.26073  9.27473   9.08614   1.000 82.68593  ? 116 ARG G NH2 1 
ATOM   4119 N  N   . SER D 1 81  ? 31.53652  2.73354   3.29458   1.000 22.07458  ? 117 SER G N   1 
ATOM   4120 C  CA  . SER D 1 81  ? 32.05354  1.93598   2.18844   1.000 20.28312  ? 117 SER G CA  1 
ATOM   4121 C  C   . SER D 1 81  ? 33.39424  1.29584   2.52475   1.000 18.32626  ? 117 SER G C   1 
ATOM   4122 O  O   . SER D 1 81  ? 34.14075  0.91714   1.60988   1.000 19.65875  ? 117 SER G O   1 
ATOM   4123 C  CB  . SER D 1 81  ? 32.19796  2.76957   0.90670   1.000 25.85822  ? 117 SER G CB  1 
ATOM   4124 O  OG  . SER D 1 81  ? 30.98703  3.41046   0.52819   1.000 26.44161  ? 117 SER G OG  1 
ATOM   4125 N  N   . GLU D 1 82  ? 33.69613  1.13147   3.81364   1.000 18.23451  ? 118 GLU G N   1 
ATOM   4126 C  CA  . GLU D 1 82  ? 35.03172  0.74331   4.25690   1.000 18.55316  ? 118 GLU G CA  1 
ATOM   4127 C  C   . GLU D 1 82  ? 35.31808  -0.74362  4.13792   1.000 17.53401  ? 118 GLU G C   1 
ATOM   4128 O  O   . GLU D 1 82  ? 36.45896  -1.14387  4.38008   1.000 18.44098  ? 118 GLU G O   1 
ATOM   4129 C  CB  . GLU D 1 82  ? 35.25609  1.17840   5.70798   1.000 17.16997  ? 118 GLU G CB  1 
ATOM   4130 C  CG  . GLU D 1 82  ? 35.18339  2.67097   5.86163   1.000 21.82733  ? 118 GLU G CG  1 
ATOM   4131 C  CD  . GLU D 1 82  ? 36.35498  3.30515   5.14229   1.000 23.46657  ? 118 GLU G CD  1 
ATOM   4132 O  OE1 . GLU D 1 82  ? 37.48910  3.19054   5.64867   1.000 28.43396  ? 118 GLU G OE1 1 
ATOM   4133 O  OE2 . GLU D 1 82  ? 36.13993  3.83234   4.03546   1.000 22.15816  ? 118 GLU G OE2 1 
ATOM   4134 N  N   . ARG D 1 83  ? 34.33898  -1.56442  3.74710   1.000 16.65334  ? 119 ARG G N   1 
ATOM   4135 C  CA  . ARG D 1 83  ? 34.54237  -3.00207  3.61010   1.000 16.04874  ? 119 ARG G CA  1 
ATOM   4136 C  C   . ARG D 1 83  ? 34.98578  -3.60622  4.93366   1.000 18.59895  ? 119 ARG G C   1 
ATOM   4137 O  O   . ARG D 1 83  ? 35.76646  -4.55978  4.97589   1.000 18.71416  ? 119 ARG G O   1 
ATOM   4138 C  CB  . ARG D 1 83  ? 35.53865  -3.32459  2.48890   1.000 18.12868  ? 119 ARG G CB  1 
ATOM   4139 C  CG  . ARG D 1 83  ? 35.06694  -2.79481  1.11939   1.000 17.10191  ? 119 ARG G CG  1 
ATOM   4140 C  CD  . ARG D 1 83  ? 34.22784  -3.82542  0.38159   1.000 16.49132  ? 119 ARG G CD  1 
ATOM   4141 N  NE  . ARG D 1 83  ? 32.81607  -3.77953  0.77876   1.000 17.81925  ? 119 ARG G NE  1 
ATOM   4142 C  CZ  . ARG D 1 83  ? 31.90234  -4.63140  0.32263   1.000 17.07816  ? 119 ARG G CZ  1 
ATOM   4143 N  NH1 . ARG D 1 83  ? 32.25108  -5.68853  -0.39679  1.000 14.49921  ? 119 ARG G NH1 1 
ATOM   4144 N  NH2 . ARG D 1 83  ? 30.60959  -4.42838  0.61405   1.000 15.58776  ? 119 ARG G NH2 1 
ATOM   4145 N  N   . THR D 1 84  ? 34.51380  -3.01073  6.02054   1.000 15.94880  ? 120 THR G N   1 
ATOM   4146 C  CA  . THR D 1 84  ? 34.57694  -3.60956  7.34070   1.000 15.52123  ? 120 THR G CA  1 
ATOM   4147 C  C   . THR D 1 84  ? 33.13301  -3.71402  7.80568   1.000 14.33376  ? 120 THR G C   1 
ATOM   4148 O  O   . THR D 1 84  ? 32.26212  -3.01417  7.28911   1.000 17.14189  ? 120 THR G O   1 
ATOM   4149 C  CB  . THR D 1 84  ? 35.40096  -2.77982  8.34052   1.000 21.21435  ? 120 THR G CB  1 
ATOM   4150 O  OG1 . THR D 1 84  ? 34.86042  -1.45528  8.45732   1.000 21.84360  ? 120 THR G OG1 1 
ATOM   4151 C  CG2 . THR D 1 84  ? 36.85217  -2.68932  7.87257   1.000 23.08608  ? 120 THR G CG2 1 
ATOM   4152 N  N   . TRP D 1 85  ? 32.88684  -4.55646  8.80055   1.000 16.46996  ? 121 TRP G N   1 
ATOM   4153 C  CA  . TRP D 1 85  ? 31.52229  -4.98658  9.07369   1.000 15.93651  ? 121 TRP G CA  1 
ATOM   4154 C  C   . TRP D 1 85  ? 31.24460  -4.90104  10.56122  1.000 16.96212  ? 121 TRP G C   1 
ATOM   4155 O  O   . TRP D 1 85  ? 32.11914  -5.17657  11.38419  1.000 18.06092  ? 121 TRP G O   1 
ATOM   4156 C  CB  . TRP D 1 85  ? 31.30346  -6.42641  8.56962   1.000 16.38077  ? 121 TRP G CB  1 
ATOM   4157 C  CG  . TRP D 1 85  ? 31.64352  -6.51513  7.09921   1.000 13.85188  ? 121 TRP G CG  1 
ATOM   4158 C  CD1 . TRP D 1 85  ? 32.87526  -6.76065  6.55002   1.000 17.26751  ? 121 TRP G CD1 1 
ATOM   4159 C  CD2 . TRP D 1 85  ? 30.74635  -6.29475  6.01045   1.000 16.75364  ? 121 TRP G CD2 1 
ATOM   4160 N  NE1 . TRP D 1 85  ? 32.79157  -6.70160  5.16692   1.000 17.44781  ? 121 TRP G NE1 1 
ATOM   4161 C  CE2 . TRP D 1 85  ? 31.49264  -6.42299  4.81675   1.000 14.98914  ? 121 TRP G CE2 1 
ATOM   4162 C  CE3 . TRP D 1 85  ? 29.37456  -5.99865  5.92849   1.000 15.00130  ? 121 TRP G CE3 1 
ATOM   4163 C  CZ2 . TRP D 1 85  ? 30.91425  -6.26305  3.54406   1.000 17.08835  ? 121 TRP G CZ2 1 
ATOM   4164 C  CZ3 . TRP D 1 85  ? 28.80206  -5.82847  4.67511   1.000 16.85109  ? 121 TRP G CZ3 1 
ATOM   4165 C  CH2 . TRP D 1 85  ? 29.56904  -5.96948  3.49163   1.000 16.73386  ? 121 TRP G CH2 1 
ATOM   4166 N  N   . ARG D 1 86  ? 29.99977  -4.55413  10.89044  1.000 16.83895  ? 122 ARG G N   1 
ATOM   4167 C  CA  . ARG D 1 86  ? 29.57002  -4.42451  12.27274  1.000 17.57743  ? 122 ARG G CA  1 
ATOM   4168 C  C   . ARG D 1 86  ? 28.18943  -5.05380  12.41913  1.000 15.81695  ? 122 ARG G C   1 
ATOM   4169 O  O   . ARG D 1 86  ? 27.32759  -4.83971  11.57005  1.000 18.99409  ? 122 ARG G O   1 
ATOM   4170 C  CB  . ARG D 1 86  ? 29.51947  -2.93748  12.65572  1.000 22.44938  ? 122 ARG G CB  1 
ATOM   4171 C  CG  . ARG D 1 86  ? 29.38999  -2.66672  14.13394  1.000 41.28810  ? 122 ARG G CG  1 
ATOM   4172 C  CD  . ARG D 1 86  ? 30.15627  -1.40737  14.54714  1.000 47.34933  ? 122 ARG G CD  1 
ATOM   4173 N  NE  . ARG D 1 86  ? 31.59014  -1.50026  14.29579  1.000 62.00244  ? 122 ARG G NE  1 
ATOM   4174 C  CZ  . ARG D 1 86  ? 32.51826  -1.60989  15.23931  1.000 57.11861  ? 122 ARG G CZ  1 
ATOM   4175 N  NH1 . ARG D 1 86  ? 32.19625  -1.76272  16.51490  1.000 42.34163  ? 122 ARG G NH1 1 
ATOM   4176 N  NH2 . ARG D 1 86  ? 33.80349  -1.57633  14.89270  1.000 62.13987  ? 122 ARG G NH2 1 
ATOM   4177 N  N   . TRP D 1 87  ? 27.97986  -5.80813  13.49265  1.000 16.77035  ? 123 TRP G N   1 
ATOM   4178 C  CA  . TRP D 1 87  ? 26.64679  -6.32860  13.79761  1.000 16.98902  ? 123 TRP G CA  1 
ATOM   4179 C  C   . TRP D 1 87  ? 25.72883  -5.19756  14.27645  1.000 19.02233  ? 123 TRP G C   1 
ATOM   4180 O  O   . TRP D 1 87  ? 26.18329  -4.12666  14.68959  1.000 22.48977  ? 123 TRP G O   1 
ATOM   4181 C  CB  . TRP D 1 87  ? 26.73687  -7.42590  14.87292  1.000 16.89494  ? 123 TRP G CB  1 
ATOM   4182 C  CG  . TRP D 1 87  ? 27.46273  -8.64626  14.39388  1.000 18.14514  ? 123 TRP G CG  1 
ATOM   4183 C  CD1 . TRP D 1 87  ? 28.76024  -9.00589  14.67085  1.000 19.69036  ? 123 TRP G CD1 1 
ATOM   4184 C  CD2 . TRP D 1 87  ? 26.94695  -9.65047  13.51755  1.000 17.69507  ? 123 TRP G CD2 1 
ATOM   4185 N  NE1 . TRP D 1 87  ? 29.07056  -10.18634 14.02267  1.000 21.96442  ? 123 TRP G NE1 1 
ATOM   4186 C  CE2 . TRP D 1 87  ? 27.97149  -10.60150 13.31417  1.000 19.76705  ? 123 TRP G CE2 1 
ATOM   4187 C  CE3 . TRP D 1 87  ? 25.71015  -9.84380  12.89409  1.000 15.43925  ? 123 TRP G CE3 1 
ATOM   4188 C  CZ2 . TRP D 1 87  ? 27.79934  -11.72722 12.49898  1.000 20.45632  ? 123 TRP G CZ2 1 
ATOM   4189 C  CZ3 . TRP D 1 87  ? 25.53759  -10.97171 12.08400  1.000 16.47993  ? 123 TRP G CZ3 1 
ATOM   4190 C  CH2 . TRP D 1 87  ? 26.56968  -11.88935 11.89556  1.000 16.81899  ? 123 TRP G CH2 1 
ATOM   4191 N  N   . VAL D 1 88  ? 24.41397  -5.44669  14.23782  1.000 16.67512  ? 124 VAL G N   1 
ATOM   4192 C  CA  . VAL D 1 88  ? 23.47651  -4.35881  14.51600  1.000 14.56648  ? 124 VAL G CA  1 
ATOM   4193 C  C   . VAL D 1 88  ? 23.52373  -3.93273  15.97591  1.000 19.65065  ? 124 VAL G C   1 
ATOM   4194 O  O   . VAL D 1 88  ? 23.01093  -2.85969  16.30932  1.000 21.40625  ? 124 VAL G O   1 
ATOM   4195 C  CB  . VAL D 1 88  ? 22.01721  -4.71282  14.13983  1.000 16.18208  ? 124 VAL G CB  1 
ATOM   4196 C  CG1 . VAL D 1 88  ? 21.80158  -4.57795  12.63279  1.000 16.55604  ? 124 VAL G CG1 1 
ATOM   4197 C  CG2 . VAL D 1 88  ? 21.62701  -6.11893  14.62704  1.000 17.71435  ? 124 VAL G CG2 1 
ATOM   4198 N  N   . ASP D 1 89  ? 24.09565  -4.74957  16.85971  1.000 21.17190  ? 125 ASP G N   1 
ATOM   4199 C  CA  . ASP D 1 89  ? 24.24177  -4.36262  18.25841  1.000 24.79909  ? 125 ASP G CA  1 
ATOM   4200 C  C   . ASP D 1 89  ? 25.50855  -3.55985  18.49746  1.000 31.53649  ? 125 ASP G C   1 
ATOM   4201 O  O   . ASP D 1 89  ? 25.83858  -3.27610  19.65520  1.000 28.41630  ? 125 ASP G O   1 
ATOM   4202 C  CB  . ASP D 1 89  ? 24.21604  -5.59592  19.17517  1.000 25.92074  ? 125 ASP G CB  1 
ATOM   4203 C  CG  . ASP D 1 89  ? 25.42293  -6.49935  18.98875  1.000 21.96535  ? 125 ASP G CG  1 
ATOM   4204 O  OD1 . ASP D 1 89  ? 26.21419  -6.27449  18.06098  1.000 30.41450  ? 125 ASP G OD1 1 
ATOM   4205 O  OD2 . ASP D 1 89  ? 25.56585  -7.45871  19.76785  1.000 31.58662  ? 125 ASP G OD2 1 
ATOM   4206 N  N   . GLY D 1 90  ? 26.22106  -3.20331  17.42942  1.000 25.89763  ? 126 GLY G N   1 
ATOM   4207 C  CA  . GLY D 1 90  ? 27.42919  -2.40812  17.50468  1.000 34.69195  ? 126 GLY G CA  1 
ATOM   4208 C  C   . GLY D 1 90  ? 28.72303  -3.19495  17.49892  1.000 34.59118  ? 126 GLY G C   1 
ATOM   4209 O  O   . GLY D 1 90  ? 29.79239  -2.59411  17.33566  1.000 36.13240  ? 126 GLY G O   1 
ATOM   4210 N  N   . THR D 1 91  ? 28.66587  -4.49436  17.65417  1.000 26.46275  ? 127 THR G N   1 
ATOM   4211 C  CA  . THR D 1 91  ? 29.91429  -5.23220  17.80816  1.000 30.98598  ? 127 THR G CA  1 
ATOM   4212 C  C   . THR D 1 91  ? 30.58310  -5.47791  16.45333  1.000 38.77327  ? 127 THR G C   1 
ATOM   4213 O  O   . THR D 1 91  ? 29.90057  -5.73441  15.45553  1.000 26.66737  ? 127 THR G O   1 
ATOM   4214 C  CB  . THR D 1 91  ? 29.66175  -6.55579  18.51754  1.000 31.72113  ? 127 THR G CB  1 
ATOM   4215 O  OG1 . THR D 1 91  ? 28.71629  -7.32892  17.77263  1.000 33.71694  ? 127 THR G OG1 1 
ATOM   4216 C  CG2 . THR D 1 91  ? 29.09755  -6.30538  19.89736  1.000 38.95490  ? 127 THR G CG2 1 
ATOM   4217 N  N   . PRO D 1 92  ? 31.91416  -5.41024  16.39642  1.000 31.54737  ? 128 PRO G N   1 
ATOM   4218 C  CA  . PRO D 1 92  ? 32.61510  -5.65172  15.13298  1.000 25.99022  ? 128 PRO G CA  1 
ATOM   4219 C  C   . PRO D 1 92  ? 32.53379  -7.11421  14.73000  1.000 23.59101  ? 128 PRO G C   1 
ATOM   4220 O  O   . PRO D 1 92  ? 32.40655  -8.00986  15.56441  1.000 25.56610  ? 128 PRO G O   1 
ATOM   4221 C  CB  . PRO D 1 92  ? 34.06136  -5.25838  15.46063  1.000 32.73739  ? 128 PRO G CB  1 
ATOM   4222 C  CG  . PRO D 1 92  ? 34.17445  -5.66250  16.92229  1.000 28.40517  ? 128 PRO G CG  1 
ATOM   4223 C  CD  . PRO D 1 92  ? 32.86643  -5.13254  17.48902  1.000 38.23233  ? 128 PRO G CD  1 
ATOM   4224 N  N   . LEU D 1 93  ? 32.61307  -7.34567  13.42865  1.000 27.03421  ? 129 LEU G N   1 
ATOM   4225 C  CA  . LEU D 1 93  ? 32.65472  -8.70786  12.91991  1.000 22.14532  ? 129 LEU G CA  1 
ATOM   4226 C  C   . LEU D 1 93  ? 33.94583  -9.37734  13.36751  1.000 23.91490  ? 129 LEU G C   1 
ATOM   4227 O  O   . LEU D 1 93  ? 35.02719  -8.79486  13.24260  1.000 26.07915  ? 129 LEU G O   1 
ATOM   4228 C  CB  . LEU D 1 93  ? 32.56461  -8.69815  11.39927  1.000 22.94934  ? 129 LEU G CB  1 
ATOM   4229 C  CG  . LEU D 1 93  ? 32.77293  -10.03916 10.69229  1.000 19.40078  ? 129 LEU G CG  1 
ATOM   4230 C  CD1 . LEU D 1 93  ? 31.66947  -11.03268 11.10754  1.000 18.75693  ? 129 LEU G CD1 1 
ATOM   4231 C  CD2 . LEU D 1 93  ? 32.80107  -9.85766  9.18064   1.000 22.29017  ? 129 LEU G CD2 1 
ATOM   4232 N  N   . THR D 1 94  ? 33.82859  -10.58538 13.91637  1.000 21.53645  ? 130 THR G N   1 
ATOM   4233 C  CA  . THR D 1 94  ? 34.99284  -11.41637 14.18943  1.000 24.60972  ? 130 THR G CA  1 
ATOM   4234 C  C   . THR D 1 94  ? 34.89606  -12.68126 13.34838  1.000 26.84668  ? 130 THR G C   1 
ATOM   4235 O  O   . THR D 1 94  ? 35.32055  -12.67705 12.18820  1.000 27.29739  ? 130 THR G O   1 
ATOM   4236 C  CB  . THR D 1 94  ? 35.10992  -11.72817 15.68592  1.000 28.81450  ? 130 THR G CB  1 
ATOM   4237 O  OG1 . THR D 1 94  ? 33.84467  -12.16277 16.19220  1.000 31.23299  ? 130 THR G OG1 1 
ATOM   4238 C  CG2 . THR D 1 94  ? 35.53204  -10.47038 16.44362  1.000 32.24745  ? 130 THR G CG2 1 
ATOM   4239 N  N   . GLU D 1 95  ? 34.31829  -13.75312 13.89282  1.000 23.20136  ? 131 GLU G N   1 
ATOM   4240 C  CA  . GLU D 1 95  ? 34.16280  -14.98419 13.12407  1.000 21.85671  ? 131 GLU G CA  1 
ATOM   4241 C  C   . GLU D 1 95  ? 33.13631  -14.76616 12.01047  1.000 21.83243  ? 131 GLU G C   1 
ATOM   4242 O  O   . GLU D 1 95  ? 32.07257  -14.18779 12.24275  1.000 22.32619  ? 131 GLU G O   1 
ATOM   4243 C  CB  . GLU D 1 95  ? 33.71985  -16.12256 14.04994  1.000 26.39157  ? 131 GLU G CB  1 
ATOM   4244 C  CG  . GLU D 1 95  ? 34.70504  -16.38108 15.19988  1.000 37.02323  ? 131 GLU G CG  1 
ATOM   4245 C  CD  . GLU D 1 95  ? 34.37887  -17.61991 16.02022  1.000 51.64489  ? 131 GLU G CD  1 
ATOM   4246 O  OE1 . GLU D 1 95  ? 35.32650  -18.34789 16.39366  1.000 57.35856  ? 131 GLU G OE1 1 
ATOM   4247 O  OE2 . GLU D 1 95  ? 33.18175  -17.87586 16.28008  1.000 47.74527  ? 131 GLU G OE2 1 
ATOM   4248 N  N   . SER D 1 96  ? 33.45938  -15.21897 10.80055  1.000 22.16782  ? 132 SER G N   1 
ATOM   4249 C  CA  . SER D 1 96  ? 32.64612  -14.94994 9.62615   1.000 20.86390  ? 132 SER G CA  1 
ATOM   4250 C  C   . SER D 1 96  ? 32.38255  -16.23772 8.85938   1.000 21.91599  ? 132 SER G C   1 
ATOM   4251 O  O   . SER D 1 96  ? 33.12496  -17.21925 8.97015   1.000 21.85465  ? 132 SER G O   1 
ATOM   4252 C  CB  . SER D 1 96  ? 33.32872  -13.93940 8.70228   1.000 19.70470  ? 132 SER G CB  1 
ATOM   4253 O  OG  . SER D 1 96  ? 34.55383  -14.48280 8.22461   1.000 21.64402  ? 132 SER G OG  1 
ATOM   4254 N  N   . TYR D 1 97  ? 31.31420  -16.20718 8.05368   1.000 18.59757  ? 133 TYR G N   1 
ATOM   4255 C  CA  . TYR D 1 97  ? 30.87190  -17.35251 7.27693   1.000 18.04252  ? 133 TYR G CA  1 
ATOM   4256 C  C   . TYR D 1 97  ? 30.52187  -16.92540 5.85735   1.000 18.56148  ? 133 TYR G C   1 
ATOM   4257 O  O   . TYR D 1 97  ? 29.52161  -17.37259 5.28038   1.000 19.60957  ? 133 TYR G O   1 
ATOM   4258 C  CB  . TYR D 1 97  ? 29.69168  -18.04966 7.96858   1.000 20.44283  ? 133 TYR G CB  1 
ATOM   4259 C  CG  . TYR D 1 97  ? 30.07810  -18.51745 9.34358   1.000 18.78426  ? 133 TYR G CG  1 
ATOM   4260 C  CD1 . TYR D 1 97  ? 30.81339  -19.69774 9.51707   1.000 23.93035  ? 133 TYR G CD1 1 
ATOM   4261 C  CD2 . TYR D 1 97  ? 29.76737  -17.76419 10.46110  1.000 18.28960  ? 133 TYR G CD2 1 
ATOM   4262 C  CE1 . TYR D 1 97  ? 31.19845  -20.12668 10.78400  1.000 23.62571  ? 133 TYR G CE1 1 
ATOM   4263 C  CE2 . TYR D 1 97  ? 30.15139  -18.17675 11.73522  1.000 21.10226  ? 133 TYR G CE2 1 
ATOM   4264 C  CZ  . TYR D 1 97  ? 30.86505  -19.35940 11.88626  1.000 23.76855  ? 133 TYR G CZ  1 
ATOM   4265 O  OH  . TYR D 1 97  ? 31.24241  -19.76466 13.14765  1.000 28.96829  ? 133 TYR G OH  1 
ATOM   4266 N  N   . TRP D 1 98  ? 31.36775  -16.07415 5.26382   1.000 17.75413  ? 134 TRP G N   1 
ATOM   4267 C  CA  . TRP D 1 98  ? 31.14401  -15.62474 3.89666   1.000 17.16632  ? 134 TRP G CA  1 
ATOM   4268 C  C   . TRP D 1 98  ? 31.12820  -16.79974 2.93829   1.000 21.60954  ? 134 TRP G C   1 
ATOM   4269 O  O   . TRP D 1 98  ? 31.93466  -17.72850 3.05487   1.000 21.78422  ? 134 TRP G O   1 
ATOM   4270 C  CB  . TRP D 1 98  ? 32.25229  -14.66141 3.45157   1.000 16.17845  ? 134 TRP G CB  1 
ATOM   4271 C  CG  . TRP D 1 98  ? 32.32305  -13.41038 4.22526   1.000 17.50343  ? 134 TRP G CG  1 
ATOM   4272 C  CD1 . TRP D 1 98  ? 33.29119  -13.05666 5.11924   1.000 17.64880  ? 134 TRP G CD1 1 
ATOM   4273 C  CD2 . TRP D 1 98  ? 31.40094  -12.32332 4.17198   1.000 16.01702  ? 134 TRP G CD2 1 
ATOM   4274 N  NE1 . TRP D 1 98  ? 33.02702  -11.81117 5.63329   1.000 19.06752  ? 134 TRP G NE1 1 
ATOM   4275 C  CE2 . TRP D 1 98  ? 31.86358  -11.34153 5.07676   1.000 14.88878  ? 134 TRP G CE2 1 
ATOM   4276 C  CE3 . TRP D 1 98  ? 30.22328  -12.08153 3.44677   1.000 16.47201  ? 134 TRP G CE3 1 
ATOM   4277 C  CZ2 . TRP D 1 98  ? 31.21413  -10.12805 5.26205   1.000 15.43240  ? 134 TRP G CZ2 1 
ATOM   4278 C  CZ3 . TRP D 1 98  ? 29.55467  -10.86814 3.64144   1.000 16.86893  ? 134 TRP G CZ3 1 
ATOM   4279 C  CH2 . TRP D 1 98  ? 30.04561  -9.90977  4.55839   1.000 15.59390  ? 134 TRP G CH2 1 
ATOM   4280 N  N   . SER D 1 99  ? 30.21276  -16.74752 1.98010   1.000 18.39875  ? 135 SER G N   1 
ATOM   4281 C  CA  A SER D 1 99  ? 30.25725  -17.73494 0.92094   0.593 21.51987  ? 135 SER G CA  1 
ATOM   4282 C  CA  B SER D 1 99  ? 30.21738  -17.68401 0.87216   0.407 21.46322  ? 135 SER G CA  1 
ATOM   4283 C  C   . SER D 1 99  ? 31.44193  -17.44610 -0.00154  1.000 27.16869  ? 135 SER G C   1 
ATOM   4284 O  O   . SER D 1 99  ? 32.07307  -16.37620 0.04190   1.000 19.68962  ? 135 SER G O   1 
ATOM   4285 C  CB  A SER D 1 99  ? 28.94317  -17.76311 0.14097   0.593 23.52848  ? 135 SER G CB  1 
ATOM   4286 C  CB  B SER D 1 99  ? 28.94282  -17.54030 0.04327   0.407 23.77114  ? 135 SER G CB  1 
ATOM   4287 O  OG  A SER D 1 99  ? 28.64556  -16.49994 -0.41331  0.593 26.55946  ? 135 SER G OG  1 
ATOM   4288 O  OG  B SER D 1 99  ? 28.61646  -18.76294 -0.58196  0.407 30.53516  ? 135 SER G OG  1 
ATOM   4289 N  N   . LEU D 1 100 ? 31.76431  -18.43667 -0.82534  1.000 22.85507  ? 136 LEU G N   1 
ATOM   4290 C  CA  . LEU D 1 100 ? 32.98028  -18.33194 -1.62156  1.000 27.82036  ? 136 LEU G CA  1 
ATOM   4291 C  C   . LEU D 1 100 ? 32.94488  -17.10259 -2.52336  1.000 25.85975  ? 136 LEU G C   1 
ATOM   4292 O  O   . LEU D 1 100 ? 31.96842  -16.86259 -3.24050  1.000 26.31630  ? 136 LEU G O   1 
ATOM   4293 C  CB  . LEU D 1 100 ? 33.17831  -19.60390 -2.44872  1.000 31.27228  ? 136 LEU G CB  1 
ATOM   4294 C  CG  . LEU D 1 100 ? 34.51109  -19.54285 -3.19040  1.000 43.65364  ? 136 LEU G CG  1 
ATOM   4295 C  CD1 . LEU D 1 100 ? 35.64077  -19.56049 -2.16370  1.000 43.68964  ? 136 LEU G CD1 1 
ATOM   4296 C  CD2 . LEU D 1 100 ? 34.64166  -20.70645 -4.15490  1.000 43.68639  ? 136 LEU G CD2 1 
ATOM   4297 N  N   . GLY D 1 101 ? 34.00763  -16.30251 -2.45783  1.000 26.13133  ? 137 GLY G N   1 
ATOM   4298 C  CA  . GLY D 1 101 ? 34.13608  -15.12342 -3.28581  1.000 23.74517  ? 137 GLY G CA  1 
ATOM   4299 C  C   . GLY D 1 101 ? 33.43862  -13.88710 -2.75822  1.000 21.73088  ? 137 GLY G C   1 
ATOM   4300 O  O   . GLY D 1 101 ? 33.44225  -12.85876 -3.44804  1.000 22.76381  ? 137 GLY G O   1 
ATOM   4301 N  N   . GLU D 1 102 ? 32.84152  -13.95526 -1.56427  1.000 18.98672  ? 138 GLU G N   1 
ATOM   4302 C  CA  . GLU D 1 102 ? 32.19397  -12.82311 -0.90305  1.000 17.63055  ? 138 GLU G CA  1 
ATOM   4303 C  C   . GLU D 1 102 ? 33.00458  -12.32586 0.29079   1.000 19.25138  ? 138 GLU G C   1 
ATOM   4304 O  O   . GLU D 1 102 ? 33.75152  -13.09658 0.91041   1.000 20.42324  ? 138 GLU G O   1 
ATOM   4305 C  CB  . GLU D 1 102 ? 30.81155  -13.24758 -0.40028  1.000 15.78922  ? 138 GLU G CB  1 
ATOM   4306 C  CG  . GLU D 1 102 ? 29.91842  -13.84739 -1.50642  1.000 16.08512  ? 138 GLU G CG  1 
ATOM   4307 C  CD  . GLU D 1 102 ? 29.59830  -12.88817 -2.64978  1.000 19.58684  ? 138 GLU G CD  1 
ATOM   4308 O  OE1 . GLU D 1 102 ? 29.75706  -11.65754 -2.49583  1.000 15.66523  ? 138 GLU G OE1 1 
ATOM   4309 O  OE2 . GLU D 1 102 ? 29.11930  -13.36884 -3.70154  1.000 18.66959  ? 138 GLU G OE2 1 
ATOM   4310 N  N   . PRO D 1 103 ? 32.82383  -11.04407 0.69811   1.000 15.44827  ? 139 PRO G N   1 
ATOM   4311 C  CA  . PRO D 1 103 ? 31.96864  -10.01068 0.07840   1.000 16.79709  ? 139 PRO G CA  1 
ATOM   4312 C  C   . PRO D 1 103 ? 32.62992  -9.43516  -1.16274  1.000 19.43405  ? 139 PRO G C   1 
ATOM   4313 O  O   . PRO D 1 103 ? 33.86174  -9.46668  -1.27135  1.000 18.60195  ? 139 PRO G O   1 
ATOM   4314 C  CB  . PRO D 1 103 ? 31.80945  -8.95944  1.19431   1.000 18.24588  ? 139 PRO G CB  1 
ATOM   4315 C  CG  . PRO D 1 103 ? 33.07843  -9.09901  2.05169   1.000 17.83457  ? 139 PRO G CG  1 
ATOM   4316 C  CD  . PRO D 1 103 ? 33.48892  -10.56294 1.93330   1.000 16.74481  ? 139 PRO G CD  1 
ATOM   4317 N  N   . ASN D 1 104 ? 31.87164  -8.89313  -2.11433  1.000 16.12006  ? 140 ASN G N   1 
ATOM   4318 C  CA  . ASN D 1 104 ? 32.48705  -8.53720  -3.38204  1.000 18.45621  ? 140 ASN G CA  1 
ATOM   4319 C  C   . ASN D 1 104 ? 31.99578  -7.25924  -4.04571  1.000 17.78792  ? 140 ASN G C   1 
ATOM   4320 O  O   . ASN D 1 104 ? 32.58656  -6.88667  -5.06039  1.000 17.81496  ? 140 ASN G O   1 
ATOM   4321 C  CB  . ASN D 1 104 ? 32.34721  -9.70488  -4.39649  1.000 17.50615  ? 140 ASN G CB  1 
ATOM   4322 C  CG  . ASN D 1 104 ? 30.89766  -9.97015  -4.80804  1.000 22.92826  ? 140 ASN G CG  1 
ATOM   4323 O  OD1 . ASN D 1 104 ? 29.95971  -9.37207  -4.27144  1.000 16.12924  ? 140 ASN G OD1 1 
ATOM   4324 N  ND2 . ASN D 1 104 ? 30.71355  -10.87283 -5.77244  1.000 19.48971  ? 140 ASN G ND2 1 
ATOM   4325 N  N   . ASN D 1 105 ? 30.98541  -6.55224  -3.51946  1.000 16.49502  ? 141 ASN G N   1 
ATOM   4326 C  CA  . ASN D 1 105 ? 30.42255  -5.38511  -4.22198  1.000 15.71369  ? 141 ASN G CA  1 
ATOM   4327 C  C   . ASN D 1 105 ? 30.21693  -5.72432  -5.69260  1.000 18.61672  ? 141 ASN G C   1 
ATOM   4328 O  O   . ASN D 1 105 ? 30.79065  -5.10292  -6.59013  1.000 18.34431  ? 141 ASN G O   1 
ATOM   4329 C  CB  . ASN D 1 105 ? 31.31453  -4.13988  -4.12325  1.000 17.58936  ? 141 ASN G CB  1 
ATOM   4330 C  CG  . ASN D 1 105 ? 31.13933  -3.38048  -2.82830  1.000 15.04804  ? 141 ASN G CG  1 
ATOM   4331 O  OD1 . ASN D 1 105 ? 30.03091  -3.28631  -2.28094  1.000 17.66585  ? 141 ASN G OD1 1 
ATOM   4332 N  ND2 . ASN D 1 105 ? 32.22832  -2.79419  -2.34360  1.000 17.24193  ? 141 ASN G ND2 1 
ATOM   4333 N  N   . TYR D 1 106 ? 29.43245  -6.77406  -5.90537  1.000 21.41759  ? 142 TYR G N   1 
ATOM   4334 C  CA  . TYR D 1 106 ? 29.24806  -7.40761  -7.20997  1.000 18.15945  ? 142 TYR G CA  1 
ATOM   4335 C  C   . TYR D 1 106 ? 29.07501  -6.39871  -8.34376  1.000 20.38762  ? 142 TYR G C   1 
ATOM   4336 O  O   . TYR D 1 106 ? 28.21405  -5.52527  -8.28736  1.000 20.36889  ? 142 TYR G O   1 
ATOM   4337 C  CB  . TYR D 1 106 ? 28.02585  -8.31179  -7.12826  1.000 17.40877  ? 142 TYR G CB  1 
ATOM   4338 C  CG  . TYR D 1 106 ? 27.79131  -9.15822  -8.34893  1.000 20.82057  ? 142 TYR G CG  1 
ATOM   4339 C  CD1 . TYR D 1 106 ? 28.73669  -10.08213 -8.77197  1.000 25.48026  ? 142 TYR G CD1 1 
ATOM   4340 C  CD2 . TYR D 1 106 ? 26.60578  -9.04251  -9.06732  1.000 30.84535  ? 142 TYR G CD2 1 
ATOM   4341 C  CE1 . TYR D 1 106 ? 28.50549  -10.86986 -9.89680  1.000 29.11461  ? 142 TYR G CE1 1 
ATOM   4342 C  CE2 . TYR D 1 106 ? 26.36716  -9.83068  -10.18703 1.000 27.12396  ? 142 TYR G CE2 1 
ATOM   4343 C  CZ  . TYR D 1 106 ? 27.31933  -10.73750 -10.58956 1.000 32.76658  ? 142 TYR G CZ  1 
ATOM   4344 O  OH  . TYR D 1 106 ? 27.07920  -11.51042 -11.69830 1.000 40.43831  ? 142 TYR G OH  1 
ATOM   4345 N  N   . GLU D 1 107 ? 29.91203  -6.52921  -9.37629  1.000 21.63230  ? 143 GLU G N   1 
ATOM   4346 C  CA  . GLU D 1 107 ? 29.82821  -5.69427  -10.58234 1.000 23.32050  ? 143 GLU G CA  1 
ATOM   4347 C  C   . GLU D 1 107 ? 29.95441  -4.19800  -10.26860 1.000 23.49720  ? 143 GLU G C   1 
ATOM   4348 O  O   . GLU D 1 107 ? 29.42354  -3.34551  -10.98636 1.000 27.74005  ? 143 GLU G O   1 
ATOM   4349 C  CB  . GLU D 1 107 ? 28.53858  -5.99723  -11.36244 1.000 27.01380  ? 143 GLU G CB  1 
ATOM   4350 C  CG  . GLU D 1 107 ? 28.52715  -7.43041  -11.90594 1.000 31.25498  ? 143 GLU G CG  1 
ATOM   4351 C  CD  . GLU D 1 107 ? 27.27370  -7.78721  -12.68286 1.000 44.26340  ? 143 GLU G CD  1 
ATOM   4352 O  OE1 . GLU D 1 107 ? 26.21255  -7.16233  -12.45217 1.000 39.38289  ? 143 GLU G OE1 1 
ATOM   4353 O  OE2 . GLU D 1 107 ? 27.35943  -8.70287  -13.52926 1.000 43.79862  ? 143 GLU G OE2 1 
ATOM   4354 N  N   . GLY D 1 108 ? 30.68502  -3.84986  -9.21263  1.000 22.05117  ? 144 GLY G N   1 
ATOM   4355 C  CA  . GLY D 1 108 ? 30.89479  -2.45457  -8.88474  1.000 22.21582  ? 144 GLY G CA  1 
ATOM   4356 C  C   . GLY D 1 108 ? 29.73897  -1.78730  -8.16755  1.000 20.07934  ? 144 GLY G C   1 
ATOM   4357 O  O   . GLY D 1 108 ? 29.80754  -0.57581  -7.91456  1.000 25.08486  ? 144 GLY G O   1 
ATOM   4358 N  N   . ARG D 1 109 ? 28.68933  -2.53629  -7.83470  1.000 22.25534  ? 145 ARG G N   1 
ATOM   4359 C  CA  . ARG D 1 109 ? 27.53320  -2.00340  -7.12208  1.000 26.28973  ? 145 ARG G CA  1 
ATOM   4360 C  C   . ARG D 1 109 ? 27.79233  -1.96065  -5.61978  1.000 20.63476  ? 145 ARG G C   1 
ATOM   4361 O  O   . ARG D 1 109 ? 28.44970  -2.83499  -5.05348  1.000 18.89176  ? 145 ARG G O   1 
ATOM   4362 C  CB  . ARG D 1 109 ? 26.28781  -2.87237  -7.34530  1.000 26.88695  ? 145 ARG G CB  1 
ATOM   4363 C  CG  . ARG D 1 109 ? 26.10661  -3.45808  -8.73520  1.000 42.11930  ? 145 ARG G CG  1 
ATOM   4364 C  CD  . ARG D 1 109 ? 24.86430  -4.37442  -8.80639  1.000 43.54373  ? 145 ARG G CD  1 
ATOM   4365 N  NE  . ARG D 1 109 ? 24.88045  -5.49945  -7.87031  1.000 49.48995  ? 145 ARG G NE  1 
ATOM   4366 C  CZ  . ARG D 1 109 ? 23.92858  -6.42673  -7.80280  1.000 48.23472  ? 145 ARG G CZ  1 
ATOM   4367 N  NH1 . ARG D 1 109 ? 22.97045  -6.50138  -8.71428  1.000 40.56940  ? 145 ARG G NH1 1 
ATOM   4368 N  NH2 . ARG D 1 109 ? 23.93771  -7.30356  -6.79786  1.000 30.72487  ? 145 ARG G NH2 1 
ATOM   4369 N  N   . GLN D 1 110 ? 27.21266  -0.96770  -4.96395  1.000 20.20137  ? 146 GLN G N   1 
ATOM   4370 C  CA  . GLN D 1 110 ? 27.33063  -0.87487  -3.51192  1.000 17.44843  ? 146 GLN G CA  1 
ATOM   4371 C  C   . GLN D 1 110 ? 26.50358  -1.95801  -2.82040  1.000 19.79100  ? 146 GLN G C   1 
ATOM   4372 O  O   . GLN D 1 110 ? 25.27034  -1.88871  -2.81577  1.000 23.22446  ? 146 GLN G O   1 
ATOM   4373 C  CB  . GLN D 1 110 ? 26.87060  0.49634   -3.04716  1.000 26.19938  ? 146 GLN G CB  1 
ATOM   4374 C  CG  . GLN D 1 110 ? 27.11002  0.66531   -1.60117  1.000 28.77620  ? 146 GLN G CG  1 
ATOM   4375 C  CD  . GLN D 1 110 ? 27.97934  1.86373   -1.29522  1.000 44.10253  ? 146 GLN G CD  1 
ATOM   4376 O  OE1 . GLN D 1 110 ? 27.57961  3.00871   -1.52520  1.000 37.86025  ? 146 GLN G OE1 1 
ATOM   4377 N  NE2 . GLN D 1 110 ? 29.18810  1.60588   -0.79606  1.000 24.57507  ? 146 GLN G NE2 1 
ATOM   4378 N  N   . GLU D 1 111 ? 27.16302  -2.91026  -2.16180  1.000 16.33963  ? 147 GLU G N   1 
ATOM   4379 C  CA  . GLU D 1 111 ? 26.46588  -4.00223  -1.46295  1.000 16.38662  ? 147 GLU G CA  1 
ATOM   4380 C  C   . GLU D 1 111 ? 26.80335  -3.91118  0.02480   1.000 17.64364  ? 147 GLU G C   1 
ATOM   4381 O  O   . GLU D 1 111 ? 27.77667  -4.51162  0.47757   1.000 16.34095  ? 147 GLU G O   1 
ATOM   4382 C  CB  . GLU D 1 111 ? 26.87155  -5.36911  -2.03970  1.000 15.10687  ? 147 GLU G CB  1 
ATOM   4383 C  CG  . GLU D 1 111 ? 26.48397  -5.49894  -3.51888  1.000 16.63596  ? 147 GLU G CG  1 
ATOM   4384 C  CD  . GLU D 1 111 ? 26.49556  -6.92516  -3.98652  1.000 18.13660  ? 147 GLU G CD  1 
ATOM   4385 O  OE1 . GLU D 1 111 ? 27.53609  -7.58684  -3.82342  1.000 17.10115  ? 147 GLU G OE1 1 
ATOM   4386 O  OE2 . GLU D 1 111 ? 25.46166  -7.37603  -4.52306  1.000 18.64147  ? 147 GLU G OE2 1 
ATOM   4387 N  N   . GLN D 1 112 ? 26.00311  -3.16924  0.79939   1.000 16.86442  ? 148 GLN G N   1 
ATOM   4388 C  CA  . GLN D 1 112 ? 26.36599  -2.87415  2.19039   1.000 15.16127  ? 148 GLN G CA  1 
ATOM   4389 C  C   . GLN D 1 112 ? 25.67319  -3.76346  3.21687   1.000 15.30820  ? 148 GLN G C   1 
ATOM   4390 O  O   . GLN D 1 112 ? 25.97904  -3.64727  4.40721   1.000 16.31972  ? 148 GLN G O   1 
ATOM   4391 C  CB  . GLN D 1 112 ? 26.04254  -1.40822  2.51827   1.000 16.62824  ? 148 GLN G CB  1 
ATOM   4392 C  CG  . GLN D 1 112 ? 26.80997  -0.45411  1.60979   1.000 19.46915  ? 148 GLN G CG  1 
ATOM   4393 C  CD  . GLN D 1 112 ? 26.50168  1.01288   1.88264   1.000 27.40650  ? 148 GLN G CD  1 
ATOM   4394 O  OE1 . GLN D 1 112 ? 25.34251  1.40309   1.99880   1.000 38.47337  ? 148 GLN G OE1 1 
ATOM   4395 N  NE2 . GLN D 1 112 ? 27.54199  1.82982   1.97334   1.000 37.36669  ? 148 GLN G NE2 1 
ATOM   4396 N  N   . CYS D 1 113 ? 24.74794  -4.62479  2.79345   1.000 14.75863  ? 149 CYS G N   1 
ATOM   4397 C  CA  . CYS D 1 113 ? 23.93531  -5.41105  3.71362   1.000 14.81931  ? 149 CYS G CA  1 
ATOM   4398 C  C   . CYS D 1 113 ? 24.17911  -6.90435  3.50741   1.000 15.27822  ? 149 CYS G C   1 
ATOM   4399 O  O   . CYS D 1 113 ? 24.49931  -7.34762  2.40753   1.000 17.50428  ? 149 CYS G O   1 
ATOM   4400 C  CB  . CYS D 1 113 ? 22.45407  -5.06951  3.51314   1.000 14.84864  ? 149 CYS G CB  1 
ATOM   4401 S  SG  . CYS D 1 113 ? 22.06147  -3.39430  4.10235   1.000 18.25232  ? 149 CYS G SG  1 
ATOM   4402 N  N   . VAL D 1 114 ? 24.01343  -7.70798  4.55704   1.000 11.83966  ? 150 VAL G N   1 
ATOM   4403 C  CA  . VAL D 1 114 ? 24.42321  -9.11358  4.47927   1.000 12.00702  ? 150 VAL G CA  1 
ATOM   4404 C  C   . VAL D 1 114 ? 23.20229  -10.02342 4.51199   1.000 13.71661  ? 150 VAL G C   1 
ATOM   4405 O  O   . VAL D 1 114 ? 22.35280  -9.90430  5.40256   1.000 13.45048  ? 150 VAL G O   1 
ATOM   4406 C  CB  . VAL D 1 114 ? 25.40023  -9.47486  5.60751   1.000 13.23464  ? 150 VAL G CB  1 
ATOM   4407 C  CG1 . VAL D 1 114 ? 25.77434  -10.94818 5.51758   1.000 12.00400  ? 150 VAL G CG1 1 
ATOM   4408 C  CG2 . VAL D 1 114 ? 26.66650  -8.61293  5.49940   1.000 12.78392  ? 150 VAL G CG2 1 
ATOM   4409 N  N   . GLU D 1 115 ? 23.14021  -10.95028 3.56341   1.000 13.84040  ? 151 GLU G N   1 
ATOM   4410 C  CA  . GLU D 1 115 ? 22.15546  -12.02349 3.56484   1.000 13.72354  ? 151 GLU G CA  1 
ATOM   4411 C  C   . GLU D 1 115 ? 22.87652  -13.35270 3.78323   1.000 14.94999  ? 151 GLU G C   1 
ATOM   4412 O  O   . GLU D 1 115 ? 24.05334  -13.51105 3.43300   1.000 14.78055  ? 151 GLU G O   1 
ATOM   4413 C  CB  . GLU D 1 115 ? 21.37861  -12.07773 2.23684   1.000 13.62269  ? 151 GLU G CB  1 
ATOM   4414 C  CG  . GLU D 1 115 ? 22.30658  -12.25424 1.02868   1.000 16.12655  ? 151 GLU G CG  1 
ATOM   4415 C  CD  . GLU D 1 115 ? 21.57248  -12.45165 -0.28876  1.000 19.43952  ? 151 GLU G CD  1 
ATOM   4416 O  OE1 . GLU D 1 115 ? 20.31191  -12.47793 -0.32758  1.000 16.93499  ? 151 GLU G OE1 1 
ATOM   4417 O  OE2 . GLU D 1 115 ? 22.27937  -12.58970 -1.30520  1.000 17.22856  ? 151 GLU G OE2 1 
ATOM   4418 N  N   . GLN D 1 116 ? 22.17056  -14.30819 4.37058   1.000 12.27114  ? 152 GLN G N   1 
ATOM   4419 C  CA  . GLN D 1 116 ? 22.58271  -15.70318 4.30001   1.000 13.85990  ? 152 GLN G CA  1 
ATOM   4420 C  C   . GLN D 1 116 ? 21.95727  -16.25498 3.02600   1.000 16.74260  ? 152 GLN G C   1 
ATOM   4421 O  O   . GLN D 1 116 ? 20.73551  -16.19687 2.87231   1.000 15.13813  ? 152 GLN G O   1 
ATOM   4422 C  CB  . GLN D 1 116 ? 22.09972  -16.48251 5.52774   1.000 14.38191  ? 152 GLN G CB  1 
ATOM   4423 C  CG  . GLN D 1 116 ? 22.14764  -18.01673 5.33127   1.000 14.52958  ? 152 GLN G CG  1 
ATOM   4424 C  CD  . GLN D 1 116 ? 23.58335  -18.54538 5.35454   1.000 17.96952  ? 152 GLN G CD  1 
ATOM   4425 O  OE1 . GLN D 1 116 ? 24.51313  -17.86281 5.82844   1.000 18.21032  ? 152 GLN G OE1 1 
ATOM   4426 N  NE2 . GLN D 1 116 ? 23.76844  -19.76878 4.87881   1.000 19.05635  ? 152 GLN G NE2 1 
ATOM   4427 N  N   . ILE D 1 117 ? 22.77510  -16.73408 2.08622   1.000 16.05902  ? 153 ILE G N   1 
ATOM   4428 C  CA  . ILE D 1 117 ? 22.20279  -17.25476 0.84746   1.000 18.72236  ? 153 ILE G CA  1 
ATOM   4429 C  C   . ILE D 1 117 ? 22.06435  -18.75721 0.96173   1.000 23.25784  ? 153 ILE G C   1 
ATOM   4430 O  O   . ILE D 1 117 ? 22.90411  -19.44728 1.55244   1.000 22.07123  ? 153 ILE G O   1 
ATOM   4431 C  CB  . ILE D 1 117 ? 23.00559  -16.89731 -0.42019  1.000 26.36959  ? 153 ILE G CB  1 
ATOM   4432 C  CG1 . ILE D 1 117 ? 24.37469  -17.56444 -0.41804  1.000 31.80843  ? 153 ILE G CG1 1 
ATOM   4433 C  CG2 . ILE D 1 117 ? 23.14305  -15.41753 -0.58050  1.000 26.40887  ? 153 ILE G CG2 1 
ATOM   4434 C  CD1 . ILE D 1 117 ? 25.31120  -16.95641 -1.43269  1.000 40.36868  ? 153 ILE G CD1 1 
ATOM   4435 N  N   . ASP D 1 118 ? 21.00044  -19.27471 0.35269   1.000 23.17380  ? 154 ASP G N   1 
ATOM   4436 C  CA  . ASP D 1 118 ? 20.77570  -20.71650 0.28713   1.000 21.00753  ? 154 ASP G CA  1 
ATOM   4437 C  C   . ASP D 1 118 ? 20.40974  -21.03268 -1.15352  1.000 28.75706  ? 154 ASP G C   1 
ATOM   4438 O  O   . ASP D 1 118 ? 19.24160  -20.93849 -1.53281  1.000 30.34564  ? 154 ASP G O   1 
ATOM   4439 C  CB  . ASP D 1 118 ? 19.69440  -21.18479 1.23642   1.000 22.27559  ? 154 ASP G CB  1 
ATOM   4440 C  CG  . ASP D 1 118 ? 19.72735  -22.68006 1.42780   1.000 28.71571  ? 154 ASP G CG  1 
ATOM   4441 O  OD1 . ASP D 1 118 ? 20.61306  -23.16450 2.17276   1.000 27.60914  ? 154 ASP G OD1 1 
ATOM   4442 O  OD2 . ASP D 1 118 ? 18.88374  -23.36395 0.80361   1.000 31.34164  ? 154 ASP G OD2 1 
ATOM   4443 N  N   . ARG D 1 119 ? 21.41798  -21.38737 -1.93356  1.000 26.81933  ? 155 ARG G N   1 
ATOM   4444 C  CA  . ARG D 1 119 ? 21.25771  -21.86587 -3.29391  1.000 51.18941  ? 155 ARG G CA  1 
ATOM   4445 C  C   . ARG D 1 119 ? 21.88731  -23.25092 -3.36516  1.000 48.00862  ? 155 ARG G C   1 
ATOM   4446 O  O   . ARG D 1 119 ? 22.69180  -23.62264 -2.50548  1.000 47.34424  ? 155 ARG G O   1 
ATOM   4447 C  CB  . ARG D 1 119 ? 21.92197  -20.91327 -4.29918  1.000 43.35519  ? 155 ARG G CB  1 
ATOM   4448 C  CG  . ARG D 1 119 ? 21.34545  -19.50154 -4.30271  1.000 52.78089  ? 155 ARG G CG  1 
ATOM   4449 C  CD  . ARG D 1 119 ? 19.86484  -19.47201 -4.63891  1.000 59.07954  ? 155 ARG G CD  1 
ATOM   4450 N  NE  . ARG D 1 119 ? 19.54244  -18.33783 -5.49832  1.000 79.08924  ? 155 ARG G NE  1 
ATOM   4451 C  CZ  . ARG D 1 119 ? 18.32021  -18.02535 -5.90977  1.000 89.95751  ? 155 ARG G CZ  1 
ATOM   4452 N  NH1 . ARG D 1 119 ? 17.26357  -18.73308 -5.54138  1.000 86.03006  ? 155 ARG G NH1 1 
ATOM   4453 N  NH2 . ARG D 1 119 ? 18.15331  -16.97268 -6.70715  1.000 84.71092  ? 155 ARG G NH2 1 
ATOM   4454 N  N   . GLU D 1 120 ? 21.51337  -24.02541 -4.38866  1.000 53.26235  ? 156 GLU G N   1 
ATOM   4455 C  CA  . GLU D 1 120 ? 22.00660  -25.39924 -4.47123  1.000 63.43567  ? 156 GLU G CA  1 
ATOM   4456 C  C   . GLU D 1 120 ? 23.52958  -25.46189 -4.41291  1.000 64.68147  ? 156 GLU G C   1 
ATOM   4457 O  O   . GLU D 1 120 ? 24.09532  -26.32796 -3.73515  1.000 65.04755  ? 156 GLU G O   1 
ATOM   4458 C  CB  . GLU D 1 120 ? 21.48303  -26.08233 -5.73697  1.000 75.01667  ? 156 GLU G CB  1 
ATOM   4459 C  CG  . GLU D 1 120 ? 19.96033  -26.10723 -5.85789  1.000 83.39600  ? 156 GLU G CG  1 
ATOM   4460 C  CD  . GLU D 1 120 ? 19.33180  -27.30874 -5.14826  1.000 92.54843  ? 156 GLU G CD  1 
ATOM   4461 O  OE1 . GLU D 1 120 ? 20.00835  -27.92817 -4.29487  1.000 81.82223  ? 156 GLU G OE1 1 
ATOM   4462 O  OE2 . GLU D 1 120 ? 18.16002  -27.63492 -5.44534  1.000 90.66367  ? 156 GLU G OE2 1 
ATOM   4463 N  N   . ASP D 1 121 ? 24.21247  -24.53410 -5.08079  1.000 60.65373  ? 157 ASP G N   1 
ATOM   4464 C  CA  . ASP D 1 121 ? 25.67004  -24.55953 -5.10634  1.000 74.01750  ? 157 ASP G CA  1 
ATOM   4465 C  C   . ASP D 1 121 ? 26.32148  -23.62473 -4.09416  1.000 73.97231  ? 157 ASP G C   1 
ATOM   4466 O  O   . ASP D 1 121 ? 27.42271  -23.92178 -3.61785  1.000 70.28670  ? 157 ASP G O   1 
ATOM   4467 C  CB  . ASP D 1 121 ? 26.18376  -24.20871 -6.50790  1.000 85.25961  ? 157 ASP G CB  1 
ATOM   4468 C  CG  . ASP D 1 121 ? 27.44374  -24.97774 -6.87613  1.000 101.55229 ? 157 ASP G CG  1 
ATOM   4469 O  OD1 . ASP D 1 121 ? 27.35049  -26.20793 -7.08108  1.000 101.99575 ? 157 ASP G OD1 1 
ATOM   4470 O  OD2 . ASP D 1 121 ? 28.52692  -24.35735 -6.95054  1.000 106.88713 ? 157 ASP G OD2 1 
ATOM   4471 N  N   . LYS D 1 122 ? 25.67362  -22.51364 -3.74751  1.000 62.61048  ? 158 LYS G N   1 
ATOM   4472 C  CA  . LYS D 1 122 ? 26.27836  -21.44967 -2.95131  1.000 54.90071  ? 158 LYS G CA  1 
ATOM   4473 C  C   . LYS D 1 122 ? 25.47923  -21.27013 -1.66692  1.000 36.87302  ? 158 LYS G C   1 
ATOM   4474 O  O   . LYS D 1 122 ? 24.27080  -21.01781 -1.72110  1.000 41.03254  ? 158 LYS G O   1 
ATOM   4475 C  CB  . LYS D 1 122 ? 26.31796  -20.14665 -3.75608  1.000 53.76968  ? 158 LYS G CB  1 
ATOM   4476 C  CG  . LYS D 1 122 ? 27.38566  -19.14377 -3.34610  1.000 53.51662  ? 158 LYS G CG  1 
ATOM   4477 C  CD  . LYS D 1 122 ? 27.22274  -17.85074 -4.14606  1.000 51.77020  ? 158 LYS G CD  1 
ATOM   4478 C  CE  . LYS D 1 122 ? 28.21175  -16.76164 -3.72343  1.000 43.97866  ? 158 LYS G CE  1 
ATOM   4479 N  NZ  . LYS D 1 122 ? 27.66616  -15.41500 -4.06680  1.000 40.72389  ? 158 LYS G NZ  1 
ATOM   4480 N  N   . LYS D 1 123 ? 26.15073  -21.42259 -0.52171  1.000 38.99978  ? 159 LYS G N   1 
ATOM   4481 C  CA  . LYS D 1 123 ? 25.56081  -21.21936 0.79607   1.000 36.01013  ? 159 LYS G CA  1 
ATOM   4482 C  C   . LYS D 1 123 ? 26.49642  -20.36886 1.64590   1.000 32.78777  ? 159 LYS G C   1 
ATOM   4483 O  O   . LYS D 1 123 ? 27.72027  -20.52588 1.58243   1.000 31.69350  ? 159 LYS G O   1 
ATOM   4484 C  CB  . LYS D 1 123 ? 25.30170  -22.55487 1.52182   1.000 40.54955  ? 159 LYS G CB  1 
ATOM   4485 C  CG  . LYS D 1 123 ? 24.18035  -23.40960 0.94870   1.000 48.26436  ? 159 LYS G CG  1 
ATOM   4486 C  CD  . LYS D 1 123 ? 24.73129  -24.50894 0.04081   1.000 56.34009  ? 159 LYS G CD  1 
ATOM   4487 C  CE  . LYS D 1 123 ? 23.72077  -25.63431 -0.15432  1.000 51.17827  ? 159 LYS G CE  1 
ATOM   4488 N  NZ  . LYS D 1 123 ? 22.31691  -25.13420 -0.16173  1.000 49.35418  ? 159 LYS G NZ  1 
ATOM   4489 N  N   . GLY D 1 124 ? 25.92336  -19.48074 2.45535   1.000 20.28328  ? 160 GLY G N   1 
ATOM   4490 C  CA  . GLY D 1 124 ? 26.71194  -18.68664 3.37510   1.000 21.26977  ? 160 GLY G CA  1 
ATOM   4491 C  C   . GLY D 1 124 ? 26.43216  -17.21677 3.16974   1.000 20.97080  ? 160 GLY G C   1 
ATOM   4492 O  O   . GLY D 1 124 ? 25.54891  -16.82750 2.39759   1.000 19.83584  ? 160 GLY G O   1 
ATOM   4493 N  N   . TRP D 1 125 ? 27.21623  -16.36763 3.83216   1.000 15.81668  ? 161 TRP G N   1 
ATOM   4494 C  CA  . TRP D 1 125 ? 26.87991  -14.94870 3.79275   1.000 14.25344  ? 161 TRP G CA  1 
ATOM   4495 C  C   . TRP D 1 125 ? 27.24726  -14.32406 2.45604   1.000 17.40437  ? 161 TRP G C   1 
ATOM   4496 O  O   . TRP D 1 125 ? 28.24197  -14.69158 1.81990   1.000 13.94685  ? 161 TRP G O   1 
ATOM   4497 C  CB  . TRP D 1 125 ? 27.61254  -14.16245 4.88330   1.000 15.65092  ? 161 TRP G CB  1 
ATOM   4498 C  CG  . TRP D 1 125 ? 27.43165  -14.61426 6.29890   1.000 15.36325  ? 161 TRP G CG  1 
ATOM   4499 C  CD1 . TRP D 1 125 ? 26.50361  -15.49615 6.80571   1.000 14.06339  ? 161 TRP G CD1 1 
ATOM   4500 C  CD2 . TRP D 1 125 ? 28.19531  -14.14961 7.40349   1.000 15.03478  ? 161 TRP G CD2 1 
ATOM   4501 N  NE1 . TRP D 1 125 ? 26.68884  -15.63076 8.17648   1.000 15.99318  ? 161 TRP G NE1 1 
ATOM   4502 C  CE2 . TRP D 1 125 ? 27.70793  -14.79522 8.56211   1.000 17.25332  ? 161 TRP G CE2 1 
ATOM   4503 C  CE3 . TRP D 1 125 ? 29.26253  -13.24237 7.52596   1.000 16.76887  ? 161 TRP G CE3 1 
ATOM   4504 C  CZ2 . TRP D 1 125 ? 28.24896  -14.56034 9.82956   1.000 18.56435  ? 161 TRP G CZ2 1 
ATOM   4505 C  CZ3 . TRP D 1 125 ? 29.79635  -13.01262 8.78430   1.000 17.42261  ? 161 TRP G CZ3 1 
ATOM   4506 C  CH2 . TRP D 1 125 ? 29.28801  -13.66747 9.91513   1.000 18.15571  ? 161 TRP G CH2 1 
ATOM   4507 N  N   . ASN D 1 126 ? 26.47663  -13.30533 2.07245   1.000 13.45812  ? 162 ASN G N   1 
ATOM   4508 C  CA  . ASN D 1 126 ? 26.75807  -12.57268 0.84707   1.000 13.72270  ? 162 ASN G CA  1 
ATOM   4509 C  C   . ASN D 1 126 ? 26.43786  -11.10895 1.09780   1.000 13.07669  ? 162 ASN G C   1 
ATOM   4510 O  O   . ASN D 1 126 ? 25.42298  -10.80926 1.73778   1.000 12.58211  ? 162 ASN G O   1 
ATOM   4511 C  CB  . ASN D 1 126 ? 25.90486  -13.10795 -0.31350  1.000 13.73935  ? 162 ASN G CB  1 
ATOM   4512 C  CG  . ASN D 1 126 ? 25.98090  -12.22880 -1.51936  1.000 14.75227  ? 162 ASN G CG  1 
ATOM   4513 O  OD1 . ASN D 1 126 ? 27.07933  -11.89274 -1.95584  1.000 15.84118  ? 162 ASN G OD1 1 
ATOM   4514 N  ND2 . ASN D 1 126 ? 24.83197  -11.84792 -2.07909  1.000 14.96075  ? 162 ASN G ND2 1 
ATOM   4515 N  N   . ASP D 1 127 ? 27.30377  -10.19583 0.63583   1.000 12.92156  ? 163 ASP G N   1 
ATOM   4516 C  CA  . ASP D 1 127 ? 26.89763  -8.79788  0.62389   1.000 12.94251  ? 163 ASP G CA  1 
ATOM   4517 C  C   . ASP D 1 127 ? 25.97055  -8.51409  -0.55303  1.000 13.20630  ? 163 ASP G C   1 
ATOM   4518 O  O   . ASP D 1 127 ? 26.20465  -8.96358  -1.69142  1.000 14.08497  ? 163 ASP G O   1 
ATOM   4519 C  CB  . ASP D 1 127 ? 28.09992  -7.84081  0.61297   1.000 12.66462  ? 163 ASP G CB  1 
ATOM   4520 C  CG  . ASP D 1 127 ? 29.01639  -8.02845  -0.57605  1.000 16.48750  ? 163 ASP G CG  1 
ATOM   4521 O  OD1 . ASP D 1 127 ? 29.07162  -9.13443  -1.16686  1.000 14.35341  ? 163 ASP G OD1 1 
ATOM   4522 O  OD2 . ASP D 1 127 ? 29.71551  -7.04421  -0.89586  1.000 19.09326  ? 163 ASP G OD2 1 
ATOM   4523 N  N   . LEU D 1 128 ? 24.90272  -7.76965  -0.26201  1.000 13.94317  ? 164 LEU G N   1 
ATOM   4524 C  CA  . LEU D 1 128 ? 23.86781  -7.50449  -1.25440  1.000 13.01368  ? 164 LEU G CA  1 
ATOM   4525 C  C   . LEU D 1 128 ? 23.41212  -6.05431  -1.15218  1.000 14.67085  ? 164 LEU G C   1 
ATOM   4526 O  O   . LEU D 1 128 ? 23.51365  -5.41906  -0.09879  1.000 14.60244  ? 164 LEU G O   1 
ATOM   4527 C  CB  . LEU D 1 128 ? 22.66870  -8.45473  -1.06569  1.000 12.67194  ? 164 LEU G CB  1 
ATOM   4528 C  CG  . LEU D 1 128 ? 21.66480  -8.46276  -2.21904  1.000 13.76037  ? 164 LEU G CG  1 
ATOM   4529 C  CD1 . LEU D 1 128 ? 22.33589  -9.04295  -3.47243  1.000 16.51093  ? 164 LEU G CD1 1 
ATOM   4530 C  CD2 . LEU D 1 128 ? 20.40409  -9.25342  -1.83826  1.000 15.56763  ? 164 LEU G CD2 1 
ATOM   4531 N  N   . VAL D 1 129 ? 22.91934  -5.52794  -2.28065  1.000 14.56453  ? 165 VAL G N   1 
ATOM   4532 C  CA  . VAL D 1 129 ? 22.30752  -4.19945  -2.28418  1.000 15.68654  ? 165 VAL G CA  1 
ATOM   4533 C  C   . VAL D 1 129 ? 21.19485  -4.13197  -1.24509  1.000 15.59183  ? 165 VAL G C   1 
ATOM   4534 O  O   . VAL D 1 129 ? 20.28564  -4.97541  -1.23302  1.000 16.93985  ? 165 VAL G O   1 
ATOM   4535 C  CB  . VAL D 1 129 ? 21.76548  -3.90276  -3.68889  1.000 18.34878  ? 165 VAL G CB  1 
ATOM   4536 C  CG1 . VAL D 1 129 ? 20.99377  -2.59315  -3.69296  1.000 20.35079  ? 165 VAL G CG1 1 
ATOM   4537 C  CG2 . VAL D 1 129 ? 22.92055  -3.91148  -4.73006  1.000 20.69506  ? 165 VAL G CG2 1 
ATOM   4538 N  N   . CYS D 1 130 ? 21.24887  -3.11495  -0.36904  1.000 16.57672  ? 166 CYS G N   1 
ATOM   4539 C  CA  . CYS D 1 130 ? 20.35798  -3.09564  0.79448   1.000 16.31324  ? 166 CYS G CA  1 
ATOM   4540 C  C   . CYS D 1 130 ? 18.90781  -2.93412  0.39608   1.000 18.85932  ? 166 CYS G C   1 
ATOM   4541 O  O   . CYS D 1 130 ? 18.01680  -3.35486  1.13862   1.000 17.15794  ? 166 CYS G O   1 
ATOM   4542 C  CB  . CYS D 1 130 ? 20.71389  -1.95994  1.75091   1.000 19.27320  ? 166 CYS G CB  1 
ATOM   4543 S  SG  . CYS D 1 130 ? 22.35887  -2.14848  2.49907   1.000 21.84876  ? 166 CYS G SG  1 
ATOM   4544 N  N   . GLU D 1 131 ? 18.65349  -2.30789  -0.74309  1.000 17.20369  ? 167 GLU G N   1 
ATOM   4545 C  CA  . GLU D 1 131 ? 17.28025  -2.10772  -1.20019  1.000 19.09697  ? 167 GLU G CA  1 
ATOM   4546 C  C   . GLU D 1 131 ? 16.67593  -3.32339  -1.89944  1.000 18.09346  ? 167 GLU G C   1 
ATOM   4547 O  O   . GLU D 1 131 ? 15.48399  -3.28130  -2.23509  1.000 20.34950  ? 167 GLU G O   1 
ATOM   4548 C  CB  . GLU D 1 131 ? 17.23361  -0.85060  -2.08724  1.000 22.53111  ? 167 GLU G CB  1 
ATOM   4549 C  CG  . GLU D 1 131 ? 18.08623  0.31555   -1.53677  1.000 39.06173  ? 167 GLU G CG  1 
ATOM   4550 C  CD  . GLU D 1 131 ? 19.49435  0.37016   -2.11668  1.000 47.35089  ? 167 GLU G CD  1 
ATOM   4551 O  OE1 . GLU D 1 131 ? 19.67630  0.86362   -3.25541  1.000 64.85846  ? 167 GLU G OE1 1 
ATOM   4552 O  OE2 . GLU D 1 131 ? 20.42346  -0.05008  -1.40342  1.000 40.68758  ? 167 GLU G OE2 1 
ATOM   4553 N  N   . PHE D 1 132 ? 17.43533  -4.40990  -2.09602  1.000 15.34963  ? 168 PHE G N   1 
ATOM   4554 C  CA  . PHE D 1 132 ? 16.84464  -5.64551  -2.60916  1.000 18.12612  ? 168 PHE G CA  1 
ATOM   4555 C  C   . PHE D 1 132 ? 16.01032  -6.29192  -1.50282  1.000 14.61641  ? 168 PHE G C   1 
ATOM   4556 O  O   . PHE D 1 132 ? 16.10785  -5.91596  -0.32932  1.000 16.67075  ? 168 PHE G O   1 
ATOM   4557 C  CB  . PHE D 1 132 ? 17.92397  -6.61867  -3.09333  1.000 17.65069  ? 168 PHE G CB  1 
ATOM   4558 C  CG  . PHE D 1 132 ? 18.61213  -6.18431  -4.36378  1.000 20.23769  ? 168 PHE G CG  1 
ATOM   4559 C  CD1 . PHE D 1 132 ? 18.25825  -4.99549  -4.99827  1.000 24.16491  ? 168 PHE G CD1 1 
ATOM   4560 C  CD2 . PHE D 1 132 ? 19.59833  -6.97338  -4.92765  1.000 22.84305  ? 168 PHE G CD2 1 
ATOM   4561 C  CE1 . PHE D 1 132 ? 18.88695  -4.59779  -6.17836  1.000 25.35293  ? 168 PHE G CE1 1 
ATOM   4562 C  CE2 . PHE D 1 132 ? 20.23946  -6.58787  -6.10088  1.000 28.30245  ? 168 PHE G CE2 1 
ATOM   4563 C  CZ  . PHE D 1 132 ? 19.87682  -5.39893  -6.72815  1.000 23.42172  ? 168 PHE G CZ  1 
ATOM   4564 N  N   . SER D 1 133 ? 15.14854  -7.23134  -1.87058  1.000 16.71200  ? 169 SER G N   1 
ATOM   4565 C  CA  . SER D 1 133 ? 14.27176  -7.78048  -0.84550  1.000 18.30951  ? 169 SER G CA  1 
ATOM   4566 C  C   . SER D 1 133 ? 14.56413  -9.24928  -0.55856  1.000 14.59384  ? 169 SER G C   1 
ATOM   4567 O  O   . SER D 1 133 ? 14.88573  -10.03155 -1.45839  1.000 18.74325  ? 169 SER G O   1 
ATOM   4568 C  CB  . SER D 1 133 ? 12.80599  -7.60242  -1.22746  1.000 23.28813  ? 169 SER G CB  1 
ATOM   4569 O  OG  . SER D 1 133 ? 12.41815  -6.26074  -0.89899  1.000 26.32507  ? 169 SER G OG  1 
ATOM   4570 N  N   . ASN D 1 134 ? 14.39774  -9.60739  0.71661   1.000 13.06432  ? 170 ASN G N   1 
ATOM   4571 C  CA  . ASN D 1 134 ? 14.59822  -10.96477 1.21219   1.000 11.38899  ? 170 ASN G CA  1 
ATOM   4572 C  C   . ASN D 1 134 ? 13.66014  -11.19302 2.38666   1.000 12.62909  ? 170 ASN G C   1 
ATOM   4573 O  O   . ASN D 1 134 ? 13.26373  -10.24765 3.08258   1.000 12.51926  ? 170 ASN G O   1 
ATOM   4574 C  CB  . ASN D 1 134 ? 16.02349  -11.18084 1.74367   1.000 12.45000  ? 170 ASN G CB  1 
ATOM   4575 C  CG  . ASN D 1 134 ? 17.00595  -11.52871 0.67780   1.000 19.46386  ? 170 ASN G CG  1 
ATOM   4576 O  OD1 . ASN D 1 134 ? 16.71491  -12.32213 -0.22591  1.000 15.68105  ? 170 ASN G OD1 1 
ATOM   4577 N  ND2 . ASN D 1 134 ? 18.22634  -10.98398 0.81569   1.000 16.86458  ? 170 ASN G ND2 1 
ATOM   4578 N  N   . PHE D 1 135 ? 13.35241  -12.46667 2.64581   1.000 12.16184  ? 171 PHE G N   1 
ATOM   4579 C  CA  . PHE D 1 135 ? 12.86058  -12.80606 3.97291   1.000 13.92295  ? 171 PHE G CA  1 
ATOM   4580 C  C   . PHE D 1 135 ? 13.92651  -12.41410 4.98548   1.000 13.09698  ? 171 PHE G C   1 
ATOM   4581 O  O   . PHE D 1 135 ? 15.09919  -12.24510 4.63655   1.000 12.64021  ? 171 PHE G O   1 
ATOM   4582 C  CB  . PHE D 1 135 ? 12.59598  -14.31113 4.07688   1.000 12.70428  ? 171 PHE G CB  1 
ATOM   4583 C  CG  . PHE D 1 135 ? 11.48999  -14.78462 3.16501   1.000 13.92833  ? 171 PHE G CG  1 
ATOM   4584 C  CD1 . PHE D 1 135 ? 10.19980  -14.28976 3.31619   1.000 16.14036  ? 171 PHE G CD1 1 
ATOM   4585 C  CD2 . PHE D 1 135 ? 11.75383  -15.69946 2.16449   1.000 18.06823  ? 171 PHE G CD2 1 
ATOM   4586 C  CE1 . PHE D 1 135 ? 9.17056   -14.71378 2.46215   1.000 21.72657  ? 171 PHE G CE1 1 
ATOM   4587 C  CE2 . PHE D 1 135 ? 10.71637  -16.13788 1.29174   1.000 17.85961  ? 171 PHE G CE2 1 
ATOM   4588 C  CZ  . PHE D 1 135 ? 9.44011   -15.64061 1.45313   1.000 17.14919  ? 171 PHE G CZ  1 
ATOM   4589 N  N   . TYR D 1 136 ? 13.52812  -12.30364 6.25902   1.000 12.60972  ? 172 TYR G N   1 
ATOM   4590 C  CA  . TYR D 1 136 ? 14.48920  -11.83218 7.24584   1.000 13.40457  ? 172 TYR G CA  1 
ATOM   4591 C  C   . TYR D 1 136 ? 14.26476  -12.55491 8.56592   1.000 14.59389  ? 172 TYR G C   1 
ATOM   4592 O  O   . TYR D 1 136 ? 13.17735  -13.07447 8.84302   1.000 15.30212  ? 172 TYR G O   1 
ATOM   4593 C  CB  . TYR D 1 136 ? 14.38162  -10.31190 7.42963   1.000 13.58347  ? 172 TYR G CB  1 
ATOM   4594 C  CG  . TYR D 1 136 ? 12.98885  -9.80718  7.74259   1.000 14.37938  ? 172 TYR G CG  1 
ATOM   4595 C  CD1 . TYR D 1 136 ? 12.13806  -9.41462  6.72424   1.000 14.74325  ? 172 TYR G CD1 1 
ATOM   4596 C  CD2 . TYR D 1 136 ? 12.55991  -9.67427  9.06421   1.000 14.85148  ? 172 TYR G CD2 1 
ATOM   4597 C  CE1 . TYR D 1 136 ? 10.86532  -8.91779  6.98483   1.000 13.90965  ? 172 TYR G CE1 1 
ATOM   4598 C  CE2 . TYR D 1 136 ? 11.27719  -9.18472  9.35108   1.000 17.77083  ? 172 TYR G CE2 1 
ATOM   4599 C  CZ  . TYR D 1 136 ? 10.44137  -8.80562  8.29711   1.000 18.76301  ? 172 TYR G CZ  1 
ATOM   4600 O  OH  . TYR D 1 136 ? 9.17336   -8.31575  8.53598   1.000 20.40694  ? 172 TYR G OH  1 
ATOM   4601 N  N   . MET D 1 137 ? 15.32553  -12.60893 9.36529   1.000 13.32468  ? 173 MET G N   1 
ATOM   4602 C  CA  A MET D 1 137 ? 15.30134  -13.27214 10.66529  0.738 13.02224  ? 173 MET G CA  1 
ATOM   4603 C  CA  B MET D 1 137 ? 15.30775  -13.27179 10.66083  0.262 13.00549  ? 173 MET G CA  1 
ATOM   4604 C  C   . MET D 1 137 ? 15.59850  -12.25475 11.75323  1.000 12.23525  ? 173 MET G C   1 
ATOM   4605 O  O   . MET D 1 137 ? 16.65076  -11.60283 11.71890  1.000 14.45920  ? 173 MET G O   1 
ATOM   4606 C  CB  A MET D 1 137 ? 16.32548  -14.40443 10.73746  0.738 13.46134  ? 173 MET G CB  1 
ATOM   4607 C  CB  B MET D 1 137 ? 16.34361  -14.39017 10.70458  0.262 13.42011  ? 173 MET G CB  1 
ATOM   4608 C  CG  A MET D 1 137 ? 16.21913  -15.19151 12.04304  0.738 13.06839  ? 173 MET G CG  1 
ATOM   4609 C  CG  B MET D 1 137 ? 16.57013  -14.91844 12.09377  0.262 13.51861  ? 173 MET G CG  1 
ATOM   4610 S  SD  A MET D 1 137 ? 17.52274  -16.44299 12.18370  0.738 15.93373  ? 173 MET G SD  1 
ATOM   4611 S  SD  B MET D 1 137 ? 15.45188  -16.28420 12.36553  0.262 24.65258  ? 173 MET G SD  1 
ATOM   4612 C  CE  A MET D 1 137 ? 16.53831  -17.88881 11.83611  0.738 20.03493  ? 173 MET G CE  1 
ATOM   4613 C  CE  B MET D 1 137 ? 16.47129  -17.64033 11.80593  0.262 18.51116  ? 173 MET G CE  1 
ATOM   4614 N  N   . CYS D 1 138 ? 14.68027  -12.13809 12.72056  1.000 12.37731  ? 174 CYS G N   1 
ATOM   4615 C  CA  . CYS D 1 138 ? 14.92352  -11.33206 13.91676  1.000 16.30200  ? 174 CYS G CA  1 
ATOM   4616 C  C   . CYS D 1 138 ? 15.47916  -12.22182 15.02294  1.000 14.83246  ? 174 CYS G C   1 
ATOM   4617 O  O   . CYS D 1 138 ? 15.21302  -13.42653 15.07310  1.000 15.65490  ? 174 CYS G O   1 
ATOM   4618 C  CB  . CYS D 1 138 ? 13.63735  -10.68521 14.43884  1.000 15.96610  ? 174 CYS G CB  1 
ATOM   4619 S  SG  . CYS D 1 138 ? 12.74132  -9.69317  13.24608  1.000 18.14107  ? 174 CYS G SG  1 
ATOM   4620 N  N   . GLU D 1 139 ? 16.23130  -11.61023 15.93401  1.000 13.36998  ? 175 GLU G N   1 
ATOM   4621 C  CA  . GLU D 1 139 ? 16.69244  -12.32560 17.11520  1.000 14.55090  ? 175 GLU G CA  1 
ATOM   4622 C  C   . GLU D 1 139 ? 16.46761  -11.42198 18.31797  1.000 14.58909  ? 175 GLU G C   1 
ATOM   4623 O  O   . GLU D 1 139 ? 16.77909  -10.22624 18.25648  1.000 16.29476  ? 175 GLU G O   1 
ATOM   4624 C  CB  . GLU D 1 139 ? 18.17334  -12.69928 17.01475  1.000 15.62168  ? 175 GLU G CB  1 
ATOM   4625 C  CG  . GLU D 1 139 ? 18.67685  -13.36197 18.30896  1.000 16.95797  ? 175 GLU G CG  1 
ATOM   4626 C  CD  . GLU D 1 139 ? 20.17660  -13.67926 18.30345  1.000 18.49853  ? 175 GLU G CD  1 
ATOM   4627 O  OE1 . GLU D 1 139 ? 20.87442  -13.32762 17.32646  1.000 16.96458  ? 175 GLU G OE1 1 
ATOM   4628 O  OE2 . GLU D 1 139 ? 20.64820  -14.31946 19.27750  1.000 16.60158  ? 175 GLU G OE2 1 
ATOM   4629 N  N   . LYS D 1 140 ? 15.90792  -11.99249 19.39220  1.000 15.78348  ? 176 LYS G N   1 
ATOM   4630 C  CA  . LYS D 1 140 ? 15.71466  -11.29410 20.66635  1.000 17.83900  ? 176 LYS G CA  1 
ATOM   4631 C  C   . LYS D 1 140 ? 16.37061  -12.08447 21.78662  1.000 19.02219  ? 176 LYS G C   1 
ATOM   4632 O  O   . LYS D 1 140 ? 15.97358  -13.21641 22.06897  1.000 18.26574  ? 176 LYS G O   1 
ATOM   4633 C  CB  . LYS D 1 140 ? 14.22519  -11.08548 20.98125  1.000 19.13704  ? 176 LYS G CB  1 
ATOM   4634 C  CG  . LYS D 1 140 ? 14.00274  -10.13567 22.20050  1.000 24.05472  ? 176 LYS G CG  1 
ATOM   4635 C  CD  . LYS D 1 140 ? 12.53264  -9.83180  22.41514  1.000 28.64803  ? 176 LYS G CD  1 
ATOM   4636 C  CE  . LYS D 1 140 ? 12.29698  -9.06497  23.72903  1.000 33.62671  ? 176 LYS G CE  1 
ATOM   4637 N  NZ  . LYS D 1 140 ? 12.92342  -7.72687  23.81579  1.000 23.19020  ? 176 LYS G NZ  1 
ATOM   4638 N  N   . ARG D 1 141 ? 17.35974  -11.47771 22.43338  1.000 18.25963  ? 177 ARG G N   1 
ATOM   4639 C  CA  . ARG D 1 141 ? 18.06359  -12.13366 23.51955  1.000 20.69188  ? 177 ARG G CA  1 
ATOM   4640 C  C   . ARG D 1 141 ? 17.16637  -12.17238 24.75022  1.000 19.52156  ? 177 ARG G C   1 
ATOM   4641 O  O   . ARG D 1 141 ? 16.60826  -11.14729 25.14244  1.000 22.21108  ? 177 ARG G O   1 
ATOM   4642 C  CB  . ARG D 1 141 ? 19.34368  -11.35274 23.79971  1.000 24.84892  ? 177 ARG G CB  1 
ATOM   4643 C  CG  . ARG D 1 141 ? 20.45728  -11.76452 22.86483  1.000 38.03968  ? 177 ARG G CG  1 
ATOM   4644 C  CD  . ARG D 1 141 ? 21.02968  -13.09172 23.28063  1.000 38.58392  ? 177 ARG G CD  1 
ATOM   4645 N  NE  . ARG D 1 141 ? 22.39434  -12.92028 23.75453  1.000 51.73194  ? 177 ARG G NE  1 
ATOM   4646 C  CZ  . ARG D 1 141 ? 22.81397  -13.29399 24.95381  1.000 52.07027  ? 177 ARG G CZ  1 
ATOM   4647 N  NH1 . ARG D 1 141 ? 21.98236  -13.81208 25.84958  1.000 53.85107  ? 177 ARG G NH1 1 
ATOM   4648 N  NH2 . ARG D 1 141 ? 24.08713  -13.11037 25.27687  1.000 46.94864  ? 177 ARG G NH2 1 
ATOM   4649 N  N   . ILE D 1 142 ? 17.00205  -13.34996 25.35918  1.000 21.40183  ? 178 ILE G N   1 
ATOM   4650 C  CA  . ILE D 1 142 ? 16.15325  -13.50152 26.53770  1.000 19.33515  ? 178 ILE G CA  1 
ATOM   4651 C  C   . ILE D 1 142 ? 16.95430  -13.97030 27.75178  1.000 24.61238  ? 178 ILE G C   1 
ATOM   4652 O  O   . ILE D 1 142 ? 16.94279  -13.32556 28.80676  1.000 29.90290  ? 178 ILE G O   1 
ATOM   4653 C  CB  . ILE D 1 142 ? 14.96781  -14.45487 26.26422  1.000 19.41543  ? 178 ILE G CB  1 
ATOM   4654 C  CG1 . ILE D 1 142 ? 14.06072  -13.88902 25.16675  1.000 22.42434  ? 178 ILE G CG1 1 
ATOM   4655 C  CG2 . ILE D 1 142 ? 14.18206  -14.74784 27.57210  1.000 21.43238  ? 178 ILE G CG2 1 
ATOM   4656 C  CD1 . ILE D 1 142 ? 13.28406  -12.63254 25.55600  1.000 21.08331  ? 178 ILE G CD1 1 
ATOM   4657 N  N   . PHE D 1 143 ? 17.68438  -15.07739 27.61160  1.000 19.11395  ? 179 PHE G N   1 
ATOM   4658 C  CA  . PHE D 1 143 ? 18.27435  -15.63589 28.82214  1.000 21.03857  ? 179 PHE G CA  1 
ATOM   4659 C  C   . PHE D 1 143 ? 19.71635  -15.17362 28.99928  1.000 28.53364  ? 179 PHE G C   1 
ATOM   4660 O  O   . PHE D 1 143 ? 20.44681  -14.98723 28.02137  1.000 25.50195  ? 179 PHE G O   1 
ATOM   4661 C  CB  . PHE D 1 143 ? 18.21423  -17.16711 28.76827  1.000 17.50053  ? 179 PHE G CB  1 
ATOM   4662 C  CG  . PHE D 1 143 ? 16.80502  -17.69205 28.66156  1.000 21.28343  ? 179 PHE G CG  1 
ATOM   4663 C  CD1 . PHE D 1 143 ? 16.00034  -17.76900 29.78544  1.000 24.22199  ? 179 PHE G CD1 1 
ATOM   4664 C  CD2 . PHE D 1 143 ? 16.26709  -18.05236 27.42787  1.000 18.86000  ? 179 PHE G CD2 1 
ATOM   4665 C  CE1 . PHE D 1 143 ? 14.68916  -18.23384 29.69243  1.000 24.72478  ? 179 PHE G CE1 1 
ATOM   4666 C  CE2 . PHE D 1 143 ? 14.96607  -18.52154 27.33111  1.000 22.27685  ? 179 PHE G CE2 1 
ATOM   4667 C  CZ  . PHE D 1 143 ? 14.17263  -18.60658 28.46638  1.000 25.30140  ? 179 PHE G CZ  1 
ATOM   4668 N  N   . PRO D 1 144 ? 20.16572  -14.98514 30.25096  1.000 28.84385  ? 180 PRO G N   1 
ATOM   4669 C  CA  . PRO D 1 144 ? 21.54126  -14.54369 30.50614  1.000 29.21216  ? 180 PRO G CA  1 
ATOM   4670 C  C   . PRO D 1 144 ? 22.57550  -15.64002 30.24939  1.000 34.11461  ? 180 PRO G C   1 
ATOM   4671 O  O   . PRO D 1 144 ? 22.22665  -16.81996 30.32324  1.000 49.08730  ? 180 PRO G O   1 
ATOM   4672 C  CB  . PRO D 1 144 ? 21.51193  -14.14213 31.99236  1.000 32.56570  ? 180 PRO G CB  1 
ATOM   4673 C  CG  . PRO D 1 144 ? 20.41193  -14.94067 32.58647  1.000 28.97801  ? 180 PRO G CG  1 
ATOM   4674 C  CD  . PRO D 1 144 ? 19.37644  -15.11434 31.48829  1.000 28.86319  ? 180 PRO G CD  1 
HETATM 4675 C  C1  . GOL E 2 .   ? 21.97095  -1.20105  49.25975  1.000 16.67155  ? 201 GOL A C1  1 
HETATM 4676 O  O1  . GOL E 2 .   ? 22.03719  -1.87138  48.01979  1.000 15.76136  ? 201 GOL A O1  1 
HETATM 4677 C  C2  . GOL E 2 .   ? 23.09728  -0.19659  49.45129  1.000 22.34299  ? 201 GOL A C2  1 
HETATM 4678 O  O2  . GOL E 2 .   ? 24.26597  -0.41563  48.67738  1.000 19.03282  ? 201 GOL A O2  1 
HETATM 4679 C  C3  . GOL E 2 .   ? 22.68244  1.24055   49.69777  1.000 41.28793  ? 201 GOL A C3  1 
HETATM 4680 O  O3  . GOL E 2 .   ? 23.69333  1.82631   50.49610  1.000 28.45503  ? 201 GOL A O3  1 
HETATM 4681 CA CA  . CA  F 3 .   ? 19.21046  2.68576   25.56794  1.000 17.28888  ? 202 CA  A CA  1 
HETATM 4682 CA CA  . CA  G 3 .   ? 24.19888  -1.98900  46.77007  1.000 16.41968  ? 203 CA  A CA  1 
HETATM 4683 C  C1  . GOL H 2 .   ? 0.08179   -35.61803 -5.08327  1.000 14.56851  ? 201 GOL B C1  1 
HETATM 4684 O  O1  . GOL H 2 .   ? 0.00312   -36.22959 -3.81599  1.000 15.37991  ? 201 GOL B O1  1 
HETATM 4685 C  C2  . GOL H 2 .   ? -0.80808  -34.40098 -5.08963  1.000 19.64037  ? 201 GOL B C2  1 
HETATM 4686 O  O2  . GOL H 2 .   ? -2.11933  -34.75908 -4.67665  1.000 16.93944  ? 201 GOL B O2  1 
HETATM 4687 C  C3  . GOL H 2 .   ? -0.73592  -33.68485 -6.42878  1.000 32.95449  ? 201 GOL B C3  1 
HETATM 4688 O  O3  . GOL H 2 .   ? -1.58375  -32.55964 -6.35618  1.000 35.08248  ? 201 GOL B O3  1 
HETATM 4689 CA CA  . CA  I 3 .   ? 2.73981   -31.13456 18.42148  1.000 17.81407  ? 202 CA  B CA  1 
HETATM 4690 CA CA  . CA  J 3 .   ? -2.14963  -36.30014 -2.70924  1.000 16.15178  ? 203 CA  B CA  1 
HETATM 4691 C  C1  . GOL K 2 .   ? -3.13701  23.67838  49.72627  1.000 17.62330  ? 201 GOL E C1  1 
HETATM 4692 O  O1  . GOL K 2 .   ? -3.07974  24.28176  48.43865  1.000 15.47360  ? 201 GOL E O1  1 
HETATM 4693 C  C2  . GOL K 2 .   ? -4.00000  22.43706  49.64427  1.000 25.18730  ? 201 GOL E C2  1 
HETATM 4694 O  O2  . GOL K 2 .   ? -5.31292  22.79213  49.23127  1.000 16.62442  ? 201 GOL E O2  1 
HETATM 4695 C  C3  . GOL K 2 .   ? -3.95355  21.69257  50.96639  1.000 30.84654  ? 201 GOL E C3  1 
HETATM 4696 O  O3  . GOL K 2 .   ? -4.80363  20.57302  50.87688  1.000 28.03802  ? 201 GOL E O3  1 
HETATM 4697 CA CA  . CA  L 3 .   ? -0.25125  20.10291  25.88481  1.000 16.68385  ? 202 CA  E CA  1 
HETATM 4698 CA CA  . CA  M 3 .   ? -5.30872  24.44366  47.24085  1.000 15.92198  ? 203 CA  E CA  1 
HETATM 4699 C  C1  . GOL N 2 .   ? 25.68377  -10.69634 -5.50690  1.000 17.04197  ? 201 GOL G C1  1 
HETATM 4700 O  O1  . GOL N 2 .   ? 25.74673  -10.06375 -4.24234  1.000 15.41827  ? 201 GOL G O1  1 
HETATM 4701 C  C2  . GOL N 2 .   ? 26.59116  -11.90275 -5.51175  1.000 21.22881  ? 201 GOL G C2  1 
HETATM 4702 O  O2  . GOL N 2 .   ? 27.89534  -11.56988 -5.06350  1.000 20.00071  ? 201 GOL G O2  1 
HETATM 4703 C  C3  . GOL N 2 .   ? 26.54129  -12.61137 -6.85683  1.000 27.65214  ? 201 GOL G C3  1 
HETATM 4704 O  O3  . GOL N 2 .   ? 27.49274  -13.65401 -6.83217  1.000 29.55652  ? 201 GOL G O3  1 
HETATM 4705 CA CA  . CA  O 3 .   ? 22.91869  -14.34378 18.35387  1.000 16.98136  ? 202 CA  G CA  1 
HETATM 4706 CA CA  . CA  P 3 .   ? 27.97709  -9.93763  -3.07843  1.000 16.23277  ? 203 CA  G CA  1 
HETATM 4707 O  O   . HOH Q 4 .   ? 13.44297  -11.01384 40.89769  1.000 34.93050  ? 301 HOH A O   1 
HETATM 4708 O  O   . HOH Q 4 .   ? 22.65405  9.40275   37.98657  1.000 26.33918  ? 302 HOH A O   1 
HETATM 4709 O  O   . HOH Q 4 .   ? 29.98919  -16.59688 40.24850  1.000 24.82526  ? 303 HOH A O   1 
HETATM 4710 O  O   . HOH Q 4 .   ? 3.82584   -1.76707  34.16977  1.000 24.37176  ? 304 HOH A O   1 
HETATM 4711 O  O   . HOH Q 4 .   ? 15.31404  -8.41836  24.97237  1.000 32.20032  ? 305 HOH A O   1 
HETATM 4712 O  O   . HOH Q 4 .   ? 0.88082   11.92611  18.39877  1.000 42.83849  ? 306 HOH A O   1 
HETATM 4713 O  O   . HOH Q 4 .   ? 9.29885   -7.51415  46.31626  1.000 20.19140  ? 307 HOH A O   1 
HETATM 4714 O  O   . HOH Q 4 .   ? -1.87809  7.92328   25.96483  1.000 35.58050  ? 308 HOH A O   1 
HETATM 4715 O  O   . HOH Q 4 .   ? 10.95300  2.52804   42.97874  1.000 17.46919  ? 309 HOH A O   1 
HETATM 4716 O  O   . HOH Q 4 .   ? 28.43922  -1.80341  26.50938  1.000 35.60731  ? 310 HOH A O   1 
HETATM 4717 O  O   . HOH Q 4 .   ? 30.54060  4.08615   37.46058  1.000 22.77730  ? 311 HOH A O   1 
HETATM 4718 O  O   . HOH Q 4 .   ? 10.66942  -12.24722 41.03887  1.000 24.69349  ? 312 HOH A O   1 
HETATM 4719 O  O   . HOH Q 4 .   ? 29.54730  0.73209   49.71741  1.000 29.31892  ? 313 HOH A O   1 
HETATM 4720 O  O   . HOH Q 4 .   ? 26.27784  -10.79754 44.14210  1.000 21.09463  ? 314 HOH A O   1 
HETATM 4721 O  O   . HOH Q 4 .   ? 16.65325  16.56485  39.49484  1.000 31.31273  ? 315 HOH A O   1 
HETATM 4722 O  O   . HOH Q 4 .   ? 32.12338  1.12628   41.07194  1.000 26.42734  ? 316 HOH A O   1 
HETATM 4723 O  O   . HOH Q 4 .   ? 2.49901   3.33389   33.73856  1.000 26.45416  ? 317 HOH A O   1 
HETATM 4724 O  O   . HOH Q 4 .   ? 6.79413   -11.64518 29.76688  1.000 28.81060  ? 318 HOH A O   1 
HETATM 4725 O  O   . HOH Q 4 .   ? 31.19992  -4.98393  44.76538  1.000 16.30653  ? 319 HOH A O   1 
HETATM 4726 O  O   . HOH Q 4 .   ? 27.36125  5.78138   28.59466  1.000 31.26878  ? 320 HOH A O   1 
HETATM 4727 O  O   . HOH Q 4 .   ? 32.65582  -12.55005 34.47905  1.000 32.59393  ? 321 HOH A O   1 
HETATM 4728 O  O   . HOH Q 4 .   ? 31.51344  -1.10919  36.71692  1.000 31.30239  ? 322 HOH A O   1 
HETATM 4729 O  O   . HOH Q 4 .   ? 21.78142  6.60207   24.58349  1.000 24.28230  ? 323 HOH A O   1 
HETATM 4730 O  O   . HOH Q 4 .   ? 18.23524  6.51370   23.91842  1.000 32.47379  ? 324 HOH A O   1 
HETATM 4731 O  O   . HOH Q 4 .   ? 10.62451  0.26761   46.66052  1.000 29.90249  ? 325 HOH A O   1 
HETATM 4732 O  O   . HOH Q 4 .   ? 2.35565   -0.52239  28.12517  1.000 36.93136  ? 326 HOH A O   1 
HETATM 4733 O  O   . HOH Q 4 .   ? 26.39304  3.33515   29.88931  1.000 33.49378  ? 327 HOH A O   1 
HETATM 4734 O  O   . HOH Q 4 .   ? 35.15896  -11.93538 39.05125  1.000 36.40214  ? 328 HOH A O   1 
HETATM 4735 O  O   . HOH Q 4 .   ? 5.01731   -8.05322  35.44701  1.000 36.00832  ? 329 HOH A O   1 
HETATM 4736 O  O   . HOH Q 4 .   ? 15.53442  8.69081   38.34130  1.000 17.02449  ? 330 HOH A O   1 
HETATM 4737 O  O   . HOH Q 4 .   ? 13.98741  12.94902  32.43651  1.000 23.76299  ? 331 HOH A O   1 
HETATM 4738 O  O   . HOH Q 4 .   ? 17.78879  1.20294   47.59528  1.000 42.52723  ? 332 HOH A O   1 
HETATM 4739 O  O   . HOH Q 4 .   ? 34.62250  -13.57728 36.12212  1.000 44.38622  ? 333 HOH A O   1 
HETATM 4740 O  O   . HOH Q 4 .   ? 2.99563   8.07127   30.76424  1.000 29.89970  ? 334 HOH A O   1 
HETATM 4741 O  O   . HOH Q 4 .   ? 23.13844  -1.99733  23.93084  1.000 28.99569  ? 335 HOH A O   1 
HETATM 4742 O  O   . HOH Q 4 .   ? 21.14157  -8.77824  21.37921  1.000 36.84236  ? 336 HOH A O   1 
HETATM 4743 O  O   . HOH Q 4 .   ? 15.57335  -2.28650  26.45429  1.000 16.03395  ? 337 HOH A O   1 
HETATM 4744 O  O   . HOH Q 4 .   ? 17.48137  13.10834  40.29731  1.000 39.75855  ? 338 HOH A O   1 
HETATM 4745 O  O   . HOH Q 4 .   ? 27.02419  3.03661   49.03614  1.000 41.08894  ? 339 HOH A O   1 
HETATM 4746 O  O   . HOH Q 4 .   ? 4.33171   -5.51293  36.80004  1.000 24.05370  ? 340 HOH A O   1 
HETATM 4747 O  O   . HOH Q 4 .   ? 17.94848  9.44910   39.91905  1.000 23.82521  ? 341 HOH A O   1 
HETATM 4748 O  O   . HOH Q 4 .   ? 14.90059  0.55833   46.22532  1.000 21.45783  ? 342 HOH A O   1 
HETATM 4749 O  O   . HOH Q 4 .   ? 19.94017  -10.46216 44.16414  1.000 23.11258  ? 343 HOH A O   1 
HETATM 4750 O  O   . HOH Q 4 .   ? 9.52641   11.18810  40.43092  1.000 18.98635  ? 344 HOH A O   1 
HETATM 4751 O  O   . HOH Q 4 .   ? 19.70267  14.15094  28.61293  1.000 25.31044  ? 345 HOH A O   1 
HETATM 4752 O  O   . HOH Q 4 .   ? 23.40556  -12.93279 38.85236  1.000 25.40874  ? 346 HOH A O   1 
HETATM 4753 O  O   . HOH Q 4 .   ? 31.52173  -4.91895  39.92501  1.000 23.06493  ? 347 HOH A O   1 
HETATM 4754 O  O   . HOH Q 4 .   ? 28.08363  9.00535   26.40009  1.000 31.23194  ? 348 HOH A O   1 
HETATM 4755 O  O   . HOH Q 4 .   ? 23.56484  11.00337  23.52337  1.000 42.40106  ? 349 HOH A O   1 
HETATM 4756 O  O   . HOH Q 4 .   ? 19.01458  0.68837   24.30494  1.000 18.39566  ? 350 HOH A O   1 
HETATM 4757 O  O   . HOH Q 4 .   ? 25.56220  -16.92878 41.47193  1.000 39.69879  ? 351 HOH A O   1 
HETATM 4758 O  O   . HOH Q 4 .   ? 25.45287  -1.72993  25.78620  1.000 32.85963  ? 352 HOH A O   1 
HETATM 4759 O  O   . HOH Q 4 .   ? 5.11813   5.39357   30.91410  1.000 21.52429  ? 353 HOH A O   1 
HETATM 4760 O  O   . HOH Q 4 .   ? -0.32983  -2.81500  29.95494  1.000 40.59518  ? 354 HOH A O   1 
HETATM 4761 O  O   . HOH Q 4 .   ? 31.97981  -5.81487  31.51416  1.000 36.48650  ? 355 HOH A O   1 
HETATM 4762 O  O   . HOH Q 4 .   ? 19.89026  14.64439  35.06407  1.000 31.97330  ? 356 HOH A O   1 
HETATM 4763 O  O   . HOH Q 4 .   ? 25.90465  0.58739   27.36851  1.000 31.07023  ? 357 HOH A O   1 
HETATM 4764 O  O   . HOH Q 4 .   ? 13.41183  -1.90127  46.93710  1.000 29.28786  ? 358 HOH A O   1 
HETATM 4765 O  O   . HOH Q 4 .   ? 9.12675   -16.52007 32.92907  1.000 35.68938  ? 359 HOH A O   1 
HETATM 4766 O  O   . HOH Q 4 .   ? 12.38144  -12.01563 33.86805  1.000 23.77696  ? 360 HOH A O   1 
HETATM 4767 O  O   . HOH Q 4 .   ? 27.61274  0.04993   29.40879  1.000 22.76761  ? 361 HOH A O   1 
HETATM 4768 O  O   . HOH Q 4 .   ? 2.44123   -0.43885  35.40407  1.000 26.25585  ? 362 HOH A O   1 
HETATM 4769 O  O   . HOH Q 4 .   ? 25.67997  11.64659  25.69359  1.000 23.22197  ? 363 HOH A O   1 
HETATM 4770 O  O   . HOH Q 4 .   ? 28.92726  -11.77825 44.40930  1.000 19.73378  ? 364 HOH A O   1 
HETATM 4771 O  O   . HOH Q 4 .   ? 34.80897  -7.31050  39.14693  1.000 27.58668  ? 365 HOH A O   1 
HETATM 4772 O  O   . HOH Q 4 .   ? 10.86999  -4.32263  48.35165  1.000 23.51354  ? 366 HOH A O   1 
HETATM 4773 O  O   . HOH Q 4 .   ? 30.88745  5.46719   41.88611  1.000 37.31894  ? 367 HOH A O   1 
HETATM 4774 O  O   . HOH Q 4 .   ? 31.39185  -5.78054  34.18681  1.000 18.29666  ? 368 HOH A O   1 
HETATM 4775 O  O   . HOH Q 4 .   ? 32.54048  -0.91751  44.42668  1.000 35.79023  ? 369 HOH A O   1 
HETATM 4776 O  O   . HOH Q 4 .   ? 5.67534   -5.07612  20.11041  1.000 34.98508  ? 370 HOH A O   1 
HETATM 4777 O  O   . HOH Q 4 .   ? -0.76169  9.27097   19.86294  1.000 37.67740  ? 371 HOH A O   1 
HETATM 4778 O  O   . HOH Q 4 .   ? 26.72021  9.04339   43.85790  1.000 34.54184  ? 372 HOH A O   1 
HETATM 4779 O  O   . HOH Q 4 .   ? 32.51123  4.56846   33.05810  1.000 31.90745  ? 373 HOH A O   1 
HETATM 4780 O  O   . HOH Q 4 .   ? 15.20760  -12.46702 33.15888  1.000 22.58896  ? 374 HOH A O   1 
HETATM 4781 O  O   . HOH Q 4 .   ? 22.13565  -9.94566  31.98891  1.000 29.18155  ? 375 HOH A O   1 
HETATM 4782 O  O   . HOH Q 4 .   ? 10.87243  6.58367   43.54211  1.000 28.87835  ? 376 HOH A O   1 
HETATM 4783 O  O   . HOH Q 4 .   ? 19.63496  4.12243   23.62909  1.000 18.82700  ? 377 HOH A O   1 
HETATM 4784 O  O   . HOH Q 4 .   ? 14.47553  -2.77045  22.31968  1.000 33.12076  ? 378 HOH A O   1 
HETATM 4785 O  O   . HOH Q 4 .   ? 23.77947  -14.67070 35.31045  1.000 36.62848  ? 379 HOH A O   1 
HETATM 4786 O  O   . HOH Q 4 .   ? 22.24715  -10.94878 29.48076  1.000 33.26421  ? 380 HOH A O   1 
HETATM 4787 O  O   . HOH Q 4 .   ? 23.83959  -11.21322 33.44516  1.000 36.24740  ? 381 HOH A O   1 
HETATM 4788 O  O   . HOH Q 4 .   ? 25.68799  8.85826   38.94736  1.000 46.26018  ? 382 HOH A O   1 
HETATM 4789 O  O   . HOH Q 4 .   ? 4.14622   -9.44164  33.45876  1.000 51.50272  ? 383 HOH A O   1 
HETATM 4790 O  O   . HOH Q 4 .   ? 18.20414  15.44044  31.64713  1.000 31.41405  ? 384 HOH A O   1 
HETATM 4791 O  O   . HOH Q 4 .   ? -1.74753  4.68252   37.31583  1.000 47.17465  ? 385 HOH A O   1 
HETATM 4792 O  O   . HOH Q 4 .   ? 9.27979   9.58754   42.71239  1.000 33.36033  ? 386 HOH A O   1 
HETATM 4793 O  O   . HOH Q 4 .   ? 16.80722  -0.91884  24.21220  1.000 21.26410  ? 387 HOH A O   1 
HETATM 4794 O  O   . HOH Q 4 .   ? 20.90526  -0.81589  23.01498  1.000 32.27038  ? 388 HOH A O   1 
HETATM 4795 O  O   . HOH Q 4 .   ? 7.031     -8.961    45.459    1.000 18.54928  ? 389 HOH A O   1 
HETATM 4796 O  O   . HOH Q 4 .   ? 32.67101  -0.89590  39.68715  1.000 36.12296  ? 390 HOH A O   1 
HETATM 4797 O  O   . HOH Q 4 .   ? 4.81972   -12.87494 30.79823  1.000 40.34589  ? 391 HOH A O   1 
HETATM 4798 O  O   . HOH Q 4 .   ? 24.27541  14.77535  29.56875  1.000 35.81010  ? 392 HOH A O   1 
HETATM 4799 O  O   . HOH Q 4 .   ? 32.23484  -2.74645  38.44195  1.000 51.13714  ? 393 HOH A O   1 
HETATM 4800 O  O   . HOH Q 4 .   ? 29.57327  -3.03716  24.37785  1.000 44.20319  ? 394 HOH A O   1 
HETATM 4801 O  O   . HOH Q 4 .   ? 18.04358  -12.14829 33.45761  1.000 47.73081  ? 395 HOH A O   1 
HETATM 4802 O  O   . HOH Q 4 .   ? 19.42621  -10.52926 31.92518  1.000 34.92736  ? 396 HOH A O   1 
HETATM 4803 O  O   . HOH Q 4 .   ? 32.23849  3.53312   39.45392  1.000 37.16598  ? 397 HOH A O   1 
HETATM 4804 O  O   . HOH Q 4 .   ? 33.65402  -2.10624  42.30434  1.000 24.75687  ? 398 HOH A O   1 
HETATM 4805 O  O   . HOH Q 4 .   ? 16.28461  -4.26103  24.36618  1.000 35.12821  ? 399 HOH A O   1 
HETATM 4806 O  O   . HOH Q 4 .   ? 11.03287  -5.30804  50.51822  1.000 56.46131  ? 400 HOH A O   1 
HETATM 4807 O  O   . HOH R 4 .   ? 18.10467  -36.21341 9.94440   1.000 29.43402  ? 301 HOH B O   1 
HETATM 4808 O  O   . HOH R 4 .   ? 8.40855   -45.14900 3.46848   1.000 30.00529  ? 302 HOH B O   1 
HETATM 4809 O  O   . HOH R 4 .   ? 2.56966   -45.41901 15.25574  1.000 44.38055  ? 303 HOH B O   1 
HETATM 4810 O  O   . HOH R 4 .   ? 2.16679   -25.64958 19.88273  1.000 31.77792  ? 304 HOH B O   1 
HETATM 4811 O  O   . HOH R 4 .   ? 2.38814   -46.94074 1.03479   1.000 32.84997  ? 305 HOH B O   1 
HETATM 4812 O  O   . HOH R 4 .   ? 8.99734   -24.18921 -0.48043  1.000 38.27876  ? 306 HOH B O   1 
HETATM 4813 O  O   . HOH R 4 .   ? 23.96245  -26.40437 18.33391  1.000 32.06506  ? 307 HOH B O   1 
HETATM 4814 O  O   . HOH R 4 .   ? -10.67537 -46.54699 9.60388   1.000 31.38713  ? 308 HOH B O   1 
HETATM 4815 O  O   . HOH R 4 .   ? -5.29952  -27.89801 15.13993  1.000 32.94515  ? 309 HOH B O   1 
HETATM 4816 O  O   . HOH R 4 .   ? 4.21759   -33.35993 -3.56468  1.000 31.49023  ? 310 HOH B O   1 
HETATM 4817 O  O   . HOH R 4 .   ? 11.52390  -46.52040 3.11125   1.000 28.29628  ? 311 HOH B O   1 
HETATM 4818 O  O   . HOH R 4 .   ? -10.94372 -34.59875 10.63112  1.000 45.68591  ? 312 HOH B O   1 
HETATM 4819 O  O   . HOH R 4 .   ? 0.22732   -27.32373 19.30528  1.000 28.28552  ? 313 HOH B O   1 
HETATM 4820 O  O   . HOH R 4 .   ? -9.96970  -32.93044 2.89265   1.000 24.49047  ? 314 HOH B O   1 
HETATM 4821 O  O   . HOH R 4 .   ? 12.739    -41.851   -2.134    1.000 19.13367  ? 315 HOH B O   1 
HETATM 4822 O  O   . HOH R 4 .   ? 4.94735   -21.03854 3.65443   1.000 34.29449  ? 316 HOH B O   1 
HETATM 4823 O  O   . HOH R 4 .   ? -4.38780  -45.10949 0.15243   1.000 19.88714  ? 317 HOH B O   1 
HETATM 4824 O  O   . HOH R 4 .   ? 11.12934  -31.87929 1.09277   1.000 16.50884  ? 318 HOH B O   1 
HETATM 4825 O  O   . HOH R 4 .   ? 16.552    -43.138   1.150     1.000 16.54419  ? 319 HOH B O   1 
HETATM 4826 O  O   . HOH R 4 .   ? 11.39357  -34.02883 -2.39893  1.000 32.07510  ? 320 HOH B O   1 
HETATM 4827 O  O   . HOH R 4 .   ? 19.13120  -26.24921 13.53832  1.000 23.71287  ? 321 HOH B O   1 
HETATM 4828 O  O   . HOH R 4 .   ? 19.30213  -34.87920 8.78587   1.000 27.88755  ? 322 HOH B O   1 
HETATM 4829 O  O   . HOH R 4 .   ? -4.97368  -31.50881 -5.09004  1.000 34.14780  ? 323 HOH B O   1 
HETATM 4830 O  O   . HOH R 4 .   ? 9.926     -42.353   20.293    1.000 30.22685  ? 324 HOH B O   1 
HETATM 4831 O  O   . HOH R 4 .   ? -1.01015  -23.82725 20.37798  1.000 35.34020  ? 325 HOH B O   1 
HETATM 4832 O  O   . HOH R 4 .   ? 4.20915   -27.44256 20.43070  1.000 24.08822  ? 326 HOH B O   1 
HETATM 4833 O  O   . HOH R 4 .   ? 22.22804  -36.96284 14.03938  1.000 43.73762  ? 327 HOH B O   1 
HETATM 4834 O  O   . HOH R 4 .   ? 19.56255  -31.10998 10.48787  1.000 26.03375  ? 328 HOH B O   1 
HETATM 4835 O  O   . HOH R 4 .   ? 7.19778   -33.73404 -2.11667  1.000 23.02661  ? 329 HOH B O   1 
HETATM 4836 O  O   . HOH R 4 .   ? 11.764    -44.179   20.076    1.000 33.09295  ? 330 HOH B O   1 
HETATM 4837 O  O   . HOH R 4 .   ? -4.14226  -32.83385 -7.30635  1.000 38.28727  ? 331 HOH B O   1 
HETATM 4838 O  O   . HOH R 4 .   ? -1.18973  -35.82444 20.09380  1.000 32.90935  ? 332 HOH B O   1 
HETATM 4839 O  O   . HOH R 4 .   ? 6.69583   -25.43845 5.75063   1.000 15.65023  ? 333 HOH B O   1 
HETATM 4840 O  O   . HOH R 4 .   ? -2.54370  -42.43008 21.47749  1.000 34.75529  ? 334 HOH B O   1 
HETATM 4841 O  O   . HOH R 4 .   ? -4.38190  -30.41754 14.06440  1.000 28.98903  ? 335 HOH B O   1 
HETATM 4842 O  O   . HOH R 4 .   ? -9.61678  -39.01808 4.15776   1.000 20.04380  ? 336 HOH B O   1 
HETATM 4843 O  O   . HOH R 4 .   ? 2.34586   -19.86507 15.12734  1.000 25.17297  ? 337 HOH B O   1 
HETATM 4844 O  O   . HOH R 4 .   ? 16.94624  -28.84008 13.38266  1.000 20.22374  ? 338 HOH B O   1 
HETATM 4845 O  O   . HOH R 4 .   ? 7.09950   -20.29876 0.23665   1.000 40.61294  ? 339 HOH B O   1 
HETATM 4846 O  O   . HOH R 4 .   ? -8.64736  -42.14748 12.73314  1.000 47.64917  ? 340 HOH B O   1 
HETATM 4847 O  O   . HOH R 4 .   ? 4.65483   -40.83045 18.77428  1.000 27.39823  ? 341 HOH B O   1 
HETATM 4848 O  O   . HOH R 4 .   ? 8.19368   -21.06426 11.78099  1.000 19.31737  ? 342 HOH B O   1 
HETATM 4849 O  O   . HOH R 4 .   ? -8.50687  -29.76944 6.30227   1.000 21.18008  ? 343 HOH B O   1 
HETATM 4850 O  O   . HOH R 4 .   ? 5.84992   -17.44053 4.56771   1.000 29.94237  ? 344 HOH B O   1 
HETATM 4851 O  O   . HOH R 4 .   ? -7.05212  -46.00211 -0.20123  1.000 18.77108  ? 345 HOH B O   1 
HETATM 4852 O  O   . HOH R 4 .   ? -7.46082  -33.61628 -5.77238  1.000 34.20322  ? 346 HOH B O   1 
HETATM 4853 O  O   . HOH R 4 .   ? 17.53867  -39.82380 7.29355   1.000 26.09586  ? 347 HOH B O   1 
HETATM 4854 O  O   . HOH R 4 .   ? -12.743   -41.593   5.070     1.000 24.37380  ? 348 HOH B O   1 
HETATM 4855 O  O   . HOH R 4 .   ? -7.14039  -40.24770 -7.61001  1.000 29.08437  ? 349 HOH B O   1 
HETATM 4856 O  O   . HOH R 4 .   ? -1.87268  -48.94930 8.19586   1.000 36.17923  ? 350 HOH B O   1 
HETATM 4857 O  O   . HOH R 4 .   ? 6.25473   -36.39135 17.75645  1.000 18.42435  ? 351 HOH B O   1 
HETATM 4858 O  O   . HOH R 4 .   ? 7.31549   -36.63027 22.75756  1.000 29.06750  ? 352 HOH B O   1 
HETATM 4859 O  O   . HOH R 4 .   ? 19.39203  -35.05264 16.39169  1.000 32.49574  ? 353 HOH B O   1 
HETATM 4860 O  O   . HOH R 4 .   ? -6.17644  -24.60625 17.17073  1.000 32.34195  ? 354 HOH B O   1 
HETATM 4861 O  O   . HOH R 4 .   ? 11.21523  -38.68385 -4.07900  1.000 24.49552  ? 355 HOH B O   1 
HETATM 4862 O  O   . HOH R 4 .   ? 4.30832   -24.71869 4.11824   1.000 19.04838  ? 356 HOH B O   1 
HETATM 4863 O  O   . HOH R 4 .   ? -5.72278  -33.77384 14.49547  1.000 23.00835  ? 357 HOH B O   1 
HETATM 4864 O  O   . HOH R 4 .   ? 8.68294   -36.10122 -2.85467  1.000 32.44517  ? 358 HOH B O   1 
HETATM 4865 O  O   . HOH R 4 .   ? 2.88325   -33.21131 19.84692  1.000 19.10530  ? 359 HOH B O   1 
HETATM 4866 O  O   . HOH R 4 .   ? 3.96817   -17.90975 7.26001   1.000 30.87189  ? 360 HOH B O   1 
HETATM 4867 O  O   . HOH R 4 .   ? -9.63800  -35.39764 7.23975   1.000 34.10551  ? 361 HOH B O   1 
HETATM 4868 O  O   . HOH R 4 .   ? -8.64350  -31.25374 18.24537  1.000 47.52706  ? 362 HOH B O   1 
HETATM 4869 O  O   . HOH R 4 .   ? 2.39727   -19.36799 8.73624   1.000 29.78179  ? 363 HOH B O   1 
HETATM 4870 O  O   . HOH R 4 .   ? 1.99535   -44.59636 0.00546   1.000 19.35432  ? 364 HOH B O   1 
HETATM 4871 O  O   . HOH R 4 .   ? 6.87588   -43.09708 19.20699  1.000 38.68845  ? 365 HOH B O   1 
HETATM 4872 O  O   . HOH R 4 .   ? -10.54254 -35.23984 -0.33408  1.000 35.93823  ? 366 HOH B O   1 
HETATM 4873 O  O   . HOH R 4 .   ? 13.92882  -29.28822 -2.40124  1.000 44.02982  ? 367 HOH B O   1 
HETATM 4874 O  O   . HOH R 4 .   ? 21.80078  -33.22674 14.35790  1.000 40.99480  ? 368 HOH B O   1 
HETATM 4875 O  O   . HOH R 4 .   ? -10.45449 -29.43399 10.83099  1.000 33.75877  ? 369 HOH B O   1 
HETATM 4876 O  O   . HOH R 4 .   ? 9.62525   -46.31335 10.48116  1.000 32.76412  ? 370 HOH B O   1 
HETATM 4877 O  O   . HOH R 4 .   ? -10.16414 -39.64838 12.40201  1.000 34.49264  ? 371 HOH B O   1 
HETATM 4878 O  O   . HOH R 4 .   ? -4.08407  -33.10753 16.65523  1.000 36.01797  ? 372 HOH B O   1 
HETATM 4879 O  O   . HOH R 4 .   ? 9.51402   -26.71640 -0.62565  1.000 51.24998  ? 373 HOH B O   1 
HETATM 4880 O  O   . HOH R 4 .   ? -8.96802  -28.65475 2.24311   1.000 33.67044  ? 374 HOH B O   1 
HETATM 4881 O  O   . HOH R 4 .   ? -3.56538  -35.29393 18.25924  1.000 33.43587  ? 375 HOH B O   1 
HETATM 4882 O  O   . HOH R 4 .   ? -3.79649  -22.22220 18.05945  1.000 25.43258  ? 376 HOH B O   1 
HETATM 4883 O  O   . HOH R 4 .   ? -6.24077  -37.74956 -9.02886  1.000 30.73684  ? 377 HOH B O   1 
HETATM 4884 O  O   . HOH R 4 .   ? 1.32041   -43.91185 11.48664  1.000 33.53339  ? 378 HOH B O   1 
HETATM 4885 O  O   . HOH R 4 .   ? -4.62306  -25.14540 -0.18627  1.000 33.63585  ? 379 HOH B O   1 
HETATM 4886 O  O   . HOH R 4 .   ? 23.04809  -25.30887 24.39321  1.000 40.71339  ? 380 HOH B O   1 
HETATM 4887 O  O   . HOH R 4 .   ? -9.57161  -39.65977 9.80043   1.000 19.85073  ? 381 HOH B O   1 
HETATM 4888 O  O   . HOH R 4 .   ? -4.27113  -32.07079 19.96478  1.000 45.06160  ? 382 HOH B O   1 
HETATM 4889 O  O   . HOH R 4 .   ? 2.47922   -29.69770 20.33708  1.000 20.62871  ? 383 HOH B O   1 
HETATM 4890 O  O   . HOH R 4 .   ? 11.40463  -27.62660 0.61107   1.000 25.52312  ? 384 HOH B O   1 
HETATM 4891 O  O   . HOH R 4 .   ? 6.95405   -46.62987 11.03446  1.000 31.22683  ? 385 HOH B O   1 
HETATM 4892 O  O   . HOH R 4 .   ? 12.77298  -24.98124 1.54702   1.000 35.43343  ? 386 HOH B O   1 
HETATM 4893 O  O   . HOH R 4 .   ? 11.85007  -29.82328 -0.68992  1.000 31.57470  ? 387 HOH B O   1 
HETATM 4894 O  O   . HOH R 4 .   ? 19.71556  -29.88379 13.15576  1.000 30.01042  ? 388 HOH B O   1 
HETATM 4895 O  O   . HOH R 4 .   ? -5.96307  -31.14053 17.45766  1.000 53.44980  ? 389 HOH B O   1 
HETATM 4896 O  O   . HOH R 4 .   ? 5.14234   -34.79773 19.84131  1.000 20.20853  ? 390 HOH B O   1 
HETATM 4897 O  O   . HOH R 4 .   ? 3.90443   -18.90302 12.93454  1.000 28.91132  ? 391 HOH B O   1 
HETATM 4898 O  O   . HOH R 4 .   ? 1.12947   -34.70587 21.06511  1.000 35.13072  ? 392 HOH B O   1 
HETATM 4899 O  O   . HOH R 4 .   ? 8.10051   -38.50917 20.98917  1.000 35.75801  ? 393 HOH B O   1 
HETATM 4900 O  O   . HOH R 4 .   ? 8.185     -16.489   -2.184    1.000 37.50613  ? 394 HOH B O   1 
HETATM 4901 O  O   . HOH R 4 .   ? -10.65909 -35.24710 4.58655   1.000 37.97575  ? 395 HOH B O   1 
HETATM 4902 O  O   . HOH R 4 .   ? 14.928    -43.355   -1.283    1.000 19.71064  ? 396 HOH B O   1 
HETATM 4903 O  O   . HOH R 4 .   ? 1.17837   -41.25949 23.65338  1.000 34.54202  ? 397 HOH B O   1 
HETATM 4904 O  O   . HOH R 4 .   ? -11.45954 -36.32801 1.57423   1.000 45.39361  ? 398 HOH B O   1 
HETATM 4905 O  O   . HOH R 4 .   ? 5.55417   -38.30031 19.74440  1.000 22.41528  ? 399 HOH B O   1 
HETATM 4906 O  O   . HOH R 4 .   ? -10.12586 -30.40099 4.14179   1.000 44.50000  ? 400 HOH B O   1 
HETATM 4907 O  O   . HOH R 4 .   ? 5.39668   -34.74208 -5.16289  1.000 42.59728  ? 401 HOH B O   1 
HETATM 4908 O  O   . HOH R 4 .   ? 4.39815   -36.93456 21.42542  1.000 32.07353  ? 402 HOH B O   1 
HETATM 4909 O  O   . HOH S 4 .   ? 5.33151   33.29077  41.35965  1.000 30.11331  ? 301 HOH E O   1 
HETATM 4910 O  O   . HOH S 4 .   ? -0.98500  14.84094  24.38361  1.000 31.41645  ? 302 HOH E O   1 
HETATM 4911 O  O   . HOH S 4 .   ? 9.682     29.865    46.800    1.000 18.00599  ? 303 HOH E O   1 
HETATM 4912 O  O   . HOH S 4 .   ? 7.66225   11.57006  44.07970  1.000 43.11073  ? 304 HOH E O   1 
HETATM 4913 O  O   . HOH S 4 .   ? -0.55509  35.18151  43.79785  1.000 33.20298  ? 305 HOH E O   1 
HETATM 4914 O  O   . HOH S 4 .   ? 15.11894  24.36906  34.56275  1.000 27.49674  ? 306 HOH E O   1 
HETATM 4915 O  O   . HOH S 4 .   ? -16.16226 34.11929  39.49256  1.000 28.31078  ? 307 HOH E O   1 
HETATM 4916 O  O   . HOH S 4 .   ? 1.37836   9.30999   40.02941  1.000 49.16284  ? 308 HOH E O   1 
HETATM 4917 O  O   . HOH S 4 .   ? 16.37469  19.34117  34.07417  1.000 25.47679  ? 309 HOH E O   1 
HETATM 4918 O  O   . HOH S 4 .   ? 15.67969  14.62846  31.02199  1.000 25.41962  ? 310 HOH E O   1 
HETATM 4919 O  O   . HOH S 4 .   ? 21.55982  15.61612  28.64982  1.000 38.90966  ? 311 HOH E O   1 
HETATM 4920 O  O   . HOH S 4 .   ? -7.46626  33.30952  44.56150  1.000 18.31219  ? 312 HOH E O   1 
HETATM 4921 O  O   . HOH S 4 .   ? -4.35661  24.90239  24.40768  1.000 33.31444  ? 313 HOH E O   1 
HETATM 4922 O  O   . HOH S 4 .   ? 16.39773  22.90757  35.69091  1.000 28.77476  ? 314 HOH E O   1 
HETATM 4923 O  O   . HOH S 4 .   ? 4.04517   21.82098  46.46727  1.000 22.96788  ? 315 HOH E O   1 
HETATM 4924 O  O   . HOH S 4 .   ? 7.89397   19.94911  43.33553  1.000 16.52334  ? 316 HOH E O   1 
HETATM 4925 O  O   . HOH S 4 .   ? -12.25617 27.48489  45.26697  1.000 15.65935  ? 317 HOH E O   1 
HETATM 4926 O  O   . HOH S 4 .   ? -9.49072  24.65746  26.71454  1.000 39.47142  ? 318 HOH E O   1 
HETATM 4927 O  O   . HOH S 4 .   ? -8.39235  16.96350  29.00978  1.000 25.51229  ? 319 HOH E O   1 
HETATM 4928 O  O   . HOH S 4 .   ? 1.84519   29.65747  25.85128  1.000 30.63821  ? 320 HOH E O   1 
HETATM 4929 O  O   . HOH S 4 .   ? 1.04654   21.48950  48.04313  1.000 32.61765  ? 321 HOH E O   1 
HETATM 4930 O  O   . HOH S 4 .   ? -7.55429  19.43000  30.23400  1.000 32.69614  ? 322 HOH E O   1 
HETATM 4931 O  O   . HOH S 4 .   ? 8.34157   34.79980  41.58603  1.000 26.96655  ? 323 HOH E O   1 
HETATM 4932 O  O   . HOH S 4 .   ? 14.62542  27.98427  37.32910  1.000 27.23747  ? 324 HOH E O   1 
HETATM 4933 O  O   . HOH S 4 .   ? -11.04065 39.17859  40.84682  1.000 23.94022  ? 325 HOH E O   1 
HETATM 4934 O  O   . HOH S 4 .   ? -11.65107 18.41194  37.96299  1.000 21.21949  ? 326 HOH E O   1 
HETATM 4935 O  O   . HOH S 4 .   ? -1.11671  32.87177  44.78963  1.000 20.08822  ? 327 HOH E O   1 
HETATM 4936 O  O   . HOH S 4 .   ? -13.23333 21.27440  41.48901  1.000 25.30077  ? 328 HOH E O   1 
HETATM 4937 O  O   . HOH S 4 .   ? 2.12775   5.93771   39.32201  1.000 28.53180  ? 329 HOH E O   1 
HETATM 4938 O  O   . HOH S 4 .   ? 1.13409   16.40872  23.76542  1.000 20.88207  ? 330 HOH E O   1 
HETATM 4939 O  O   . HOH S 4 .   ? 0.99933   12.90295  40.08586  1.000 20.61347  ? 331 HOH E O   1 
HETATM 4940 O  O   . HOH S 4 .   ? 4.75322   9.54514   32.35732  1.000 24.21405  ? 332 HOH E O   1 
HETATM 4941 O  O   . HOH S 4 .   ? 3.33062   13.76658  38.44488  1.000 15.20837  ? 333 HOH E O   1 
HETATM 4942 O  O   . HOH S 4 .   ? 19.23505  20.84943  30.31704  1.000 37.13917  ? 334 HOH E O   1 
HETATM 4943 O  O   . HOH S 4 .   ? -2.86820  16.44911  24.84427  1.000 29.71451  ? 335 HOH E O   1 
HETATM 4944 O  O   . HOH S 4 .   ? 3.47228   25.11404  26.89676  1.000 16.68546  ? 336 HOH E O   1 
HETATM 4945 O  O   . HOH S 4 .   ? 13.75671  17.30489  31.18156  1.000 23.64743  ? 337 HOH E O   1 
HETATM 4946 O  O   . HOH S 4 .   ? 5.07745   25.69556  21.76235  1.000 35.40126  ? 338 HOH E O   1 
HETATM 4947 O  O   . HOH S 4 .   ? -11.99404 16.73933  42.00125  1.000 40.06099  ? 339 HOH E O   1 
HETATM 4948 O  O   . HOH S 4 .   ? -15.79394 29.75811  39.53882  1.000 32.21601  ? 340 HOH E O   1 
HETATM 4949 O  O   . HOH S 4 .   ? -4.18163  12.82769  23.57331  1.000 30.51201  ? 341 HOH E O   1 
HETATM 4950 O  O   . HOH S 4 .   ? -12.65696 27.43154  40.38924  1.000 20.59389  ? 342 HOH E O   1 
HETATM 4951 O  O   . HOH S 4 .   ? 0.52872   6.38869   36.89400  1.000 39.01935  ? 343 HOH E O   1 
HETATM 4952 O  O   . HOH S 4 .   ? -12.63583 23.79881  37.17995  1.000 35.05038  ? 344 HOH E O   1 
HETATM 4953 O  O   . HOH S 4 .   ? -4.97324  37.26926  36.28266  1.000 33.04200  ? 345 HOH E O   1 
HETATM 4954 O  O   . HOH S 4 .   ? -4.02793  9.26940   22.87409  1.000 36.37550  ? 346 HOH E O   1 
HETATM 4955 O  O   . HOH S 4 .   ? -11.61997 30.66153  31.80917  1.000 38.40270  ? 347 HOH E O   1 
HETATM 4956 O  O   . HOH S 4 .   ? -13.06600 28.35978  31.95455  1.000 34.22772  ? 348 HOH E O   1 
HETATM 4957 O  O   . HOH S 4 .   ? -13.62595 35.31648  34.94600  1.000 31.29034  ? 349 HOH E O   1 
HETATM 4958 O  O   . HOH S 4 .   ? -1.00501  34.03319  48.86464  1.000 32.21165  ? 350 HOH E O   1 
HETATM 4959 O  O   . HOH S 4 .   ? -0.50956  33.96679  29.50352  1.000 39.92069  ? 351 HOH E O   1 
HETATM 4960 O  O   . HOH S 4 .   ? -1.02721  8.62127   28.82708  1.000 25.68062  ? 352 HOH E O   1 
HETATM 4961 O  O   . HOH S 4 .   ? 6.06730   14.87970  44.93159  1.000 40.76173  ? 353 HOH E O   1 
HETATM 4962 O  O   . HOH S 4 .   ? -7.87657  13.38574  44.29504  1.000 34.23386  ? 354 HOH E O   1 
HETATM 4963 O  O   . HOH S 4 .   ? -4.56211  35.39279  39.41562  1.000 30.57961  ? 355 HOH E O   1 
HETATM 4964 O  O   . HOH S 4 .   ? -10.068   34.203    44.845    1.000 17.81421  ? 356 HOH E O   1 
HETATM 4965 O  O   . HOH S 4 .   ? 7.984     26.532    48.762    1.000 24.97969  ? 357 HOH E O   1 
HETATM 4966 O  O   . HOH S 4 .   ? -8.76669  22.56261  29.83861  1.000 22.48852  ? 358 HOH E O   1 
HETATM 4967 O  O   . HOH S 4 .   ? 7.80803   31.15691  24.43473  1.000 34.22196  ? 359 HOH E O   1 
HETATM 4968 O  O   . HOH S 4 .   ? -9.33933  13.76643  26.67368  1.000 29.63561  ? 360 HOH E O   1 
HETATM 4969 O  O   . HOH S 4 .   ? -0.11931  22.18993  24.62639  1.000 17.13070  ? 361 HOH E O   1 
HETATM 4970 O  O   . HOH S 4 .   ? -9.27266  25.78005  53.73470  1.000 30.52609  ? 362 HOH E O   1 
HETATM 4971 O  O   . HOH S 4 .   ? -12.41029 28.32188  34.71835  1.000 18.88910  ? 363 HOH E O   1 
HETATM 4972 O  O   . HOH S 4 .   ? 21.84204  20.74915  22.52539  1.000 37.30263  ? 364 HOH E O   1 
HETATM 4973 O  O   . HOH S 4 .   ? 3.57959   34.93407  33.83203  1.000 32.85039  ? 365 HOH E O   1 
HETATM 4974 O  O   . HOH S 4 .   ? -13.56887 23.35184  44.97822  1.000 31.22305  ? 366 HOH E O   1 
HETATM 4975 O  O   . HOH S 4 .   ? 10.67036  17.27675  46.59149  1.000 37.49339  ? 367 HOH E O   1 
HETATM 4976 O  O   . HOH S 4 .   ? -7.47158  21.04054  51.94618  1.000 37.24319  ? 368 HOH E O   1 
HETATM 4977 O  O   . HOH S 4 .   ? 7.81339   21.52171  46.60471  1.000 32.31355  ? 369 HOH E O   1 
HETATM 4978 O  O   . HOH S 4 .   ? -1.15413  7.93504   35.09216  1.000 27.35322  ? 370 HOH E O   1 
HETATM 4979 O  O   . HOH S 4 .   ? -3.25063  32.43389  32.55620  1.000 27.86915  ? 371 HOH E O   1 
HETATM 4980 O  O   . HOH S 4 .   ? -6.91900  11.36375  25.74988  1.000 27.74154  ? 372 HOH E O   1 
HETATM 4981 O  O   . HOH S 4 .   ? 5.47940   24.14120  47.47075  1.000 29.43184  ? 373 HOH E O   1 
HETATM 4982 O  O   . HOH S 4 .   ? -10.50411 21.97053  50.59354  1.000 32.99047  ? 374 HOH E O   1 
HETATM 4983 O  O   . HOH S 4 .   ? 18.82686  11.47259  19.05668  1.000 42.99481  ? 375 HOH E O   1 
HETATM 4984 O  O   . HOH S 4 .   ? 16.77136  23.30847  28.03433  1.000 36.25804  ? 376 HOH E O   1 
HETATM 4985 O  O   . HOH S 4 .   ? -13.65199 18.11610  33.50457  1.000 37.50404  ? 377 HOH E O   1 
HETATM 4986 O  O   . HOH S 4 .   ? 3.47203   8.01925   43.48063  1.000 42.63201  ? 378 HOH E O   1 
HETATM 4987 O  O   . HOH S 4 .   ? -0.52224  18.81515  23.91837  1.000 20.77723  ? 379 HOH E O   1 
HETATM 4988 O  O   . HOH S 4 .   ? -4.87881  33.85672  34.09498  1.000 34.05110  ? 380 HOH E O   1 
HETATM 4989 O  O   . HOH S 4 .   ? 7.95072   15.55729  43.76146  1.000 24.42295  ? 381 HOH E O   1 
HETATM 4990 O  O   . HOH S 4 .   ? -7.13484  21.65630  23.72236  1.000 40.39267  ? 382 HOH E O   1 
HETATM 4991 O  O   . HOH S 4 .   ? -6.85049  24.26594  26.16214  1.000 42.74707  ? 383 HOH E O   1 
HETATM 4992 O  O   . HOH S 4 .   ? -10.62556 26.43068  52.18349  1.000 40.14037  ? 384 HOH E O   1 
HETATM 4993 O  O   . HOH S 4 .   ? 8.68203   17.95676  45.28415  1.000 30.81538  ? 385 HOH E O   1 
HETATM 4994 O  O   . HOH S 4 .   ? -3.17104  33.51416  29.95421  1.000 33.27642  ? 386 HOH E O   1 
HETATM 4995 O  O   . HOH S 4 .   ? 16.48084  18.18547  31.48602  1.000 31.59578  ? 387 HOH E O   1 
HETATM 4996 O  O   . HOH S 4 .   ? -6.74131  13.76830  39.38060  1.000 43.92949  ? 388 HOH E O   1 
HETATM 4997 O  O   . HOH S 4 .   ? 9.57881   12.78913  42.74590  1.000 32.93765  ? 389 HOH E O   1 
HETATM 4998 O  O   . HOH S 4 .   ? 0.45840   7.42782   31.12285  1.000 29.73709  ? 390 HOH E O   1 
HETATM 4999 O  O   . HOH S 4 .   ? -1.79140  23.53947  23.50719  1.000 45.94139  ? 391 HOH E O   1 
HETATM 5000 O  O   . HOH S 4 .   ? 2.20270   23.74260  24.64345  1.000 22.98245  ? 392 HOH E O   1 
HETATM 5001 O  O   . HOH S 4 .   ? 8.77520   33.72764  24.88920  1.000 33.41172  ? 393 HOH E O   1 
HETATM 5002 O  O   . HOH S 4 .   ? 2.25446   4.58974   31.37762  1.000 42.65560  ? 394 HOH E O   1 
HETATM 5003 O  O   . HOH S 4 .   ? 8.46875   31.38212  22.13557  1.000 35.24471  ? 395 HOH E O   1 
HETATM 5004 O  O   . HOH S 4 .   ? 11.890    31.357    46.044    1.000 19.17686  ? 396 HOH E O   1 
HETATM 5005 O  O   . HOH S 4 .   ? -13.86055 23.45165  40.13339  1.000 44.13693  ? 397 HOH E O   1 
HETATM 5006 O  O   . HOH S 4 .   ? 18.09916  23.15544  21.77806  1.000 44.08022  ? 398 HOH E O   1 
HETATM 5007 O  O   . HOH S 4 .   ? -5.95145  11.40920  23.50317  1.000 39.48367  ? 399 HOH E O   1 
HETATM 5008 O  O   . HOH S 4 .   ? -0.70273  33.08205  32.63786  1.000 37.82492  ? 400 HOH E O   1 
HETATM 5009 O  O   . HOH S 4 .   ? -14.68874 24.47700  42.82397  1.000 26.48932  ? 401 HOH E O   1 
HETATM 5010 O  O   . HOH S 4 .   ? 12.68334  16.46806  46.30624  1.000 48.90334  ? 402 HOH E O   1 
HETATM 5011 O  O   . HOH S 4 .   ? 2.82511   27.11515  25.02714  1.000 25.90622  ? 403 HOH E O   1 
HETATM 5012 O  O   . HOH S 4 .   ? -13.43779 18.97737  40.02024  1.000 41.41597  ? 404 HOH E O   1 
HETATM 5013 O  O   . HOH S 4 .   ? 5.33028   24.13292  49.61989  1.000 54.29282  ? 405 HOH E O   1 
HETATM 5014 O  O   . HOH S 4 .   ? 2.28933   22.78714  49.77537  1.000 44.21428  ? 406 HOH E O   1 
HETATM 5015 O  O   . HOH T 4 .   ? 19.03924  0.40208   -5.28152  1.000 54.16829  ? 301 HOH G O   1 
HETATM 5016 O  O   . HOH T 4 .   ? 14.69417  -22.90899 0.33919   1.000 37.10851  ? 302 HOH G O   1 
HETATM 5017 O  O   . HOH T 4 .   ? 6.40050   -11.24548 8.47816   1.000 24.84624  ? 303 HOH G O   1 
HETATM 5018 O  O   . HOH T 4 .   ? 12.94100  -4.33027  -2.48618  1.000 20.42532  ? 304 HOH G O   1 
HETATM 5019 O  O   . HOH T 4 .   ? 21.71044  -13.08170 -3.75537  1.000 30.20929  ? 305 HOH G O   1 
HETATM 5020 O  O   . HOH T 4 .   ? 18.66769  -12.69414 -2.30694  1.000 24.94030  ? 306 HOH G O   1 
HETATM 5021 O  O   . HOH T 4 .   ? 23.25270  0.83826   0.56045   1.000 34.64953  ? 307 HOH G O   1 
HETATM 5022 O  O   . HOH T 4 .   ? 21.06930  -25.16038 4.19373   1.000 35.84303  ? 308 HOH G O   1 
HETATM 5023 O  O   . HOH T 4 .   ? 33.70165  4.64304   3.46263   1.000 24.34143  ? 309 HOH G O   1 
HETATM 5024 O  O   . HOH T 4 .   ? 30.10691  -1.11121  -0.40487  1.000 19.49976  ? 310 HOH G O   1 
HETATM 5025 O  O   . HOH T 4 .   ? 21.70978  -18.27804 20.16894  1.000 29.50958  ? 311 HOH G O   1 
HETATM 5026 O  O   . HOH T 4 .   ? 14.76135  -14.40317 0.86028   1.000 15.38982  ? 312 HOH G O   1 
HETATM 5027 O  O   . HOH T 4 .   ? 36.30728  0.64673   9.23006   1.000 30.93182  ? 313 HOH G O   1 
HETATM 5028 O  O   . HOH T 4 .   ? 38.86599  -0.00630  4.10928   1.000 31.41294  ? 314 HOH G O   1 
HETATM 5029 O  O   . HOH T 4 .   ? 26.76469  -21.63927 20.41139  1.000 33.58290  ? 315 HOH G O   1 
HETATM 5030 O  O   . HOH T 4 .   ? 29.53593  -9.88019  17.79525  1.000 38.03773  ? 316 HOH G O   1 
HETATM 5031 O  O   . HOH T 4 .   ? 6.61137   -19.50124 13.24374  1.000 22.35518  ? 317 HOH G O   1 
HETATM 5032 O  O   . HOH T 4 .   ? 33.38389  -12.62486 -6.12175  1.000 33.31427  ? 318 HOH G O   1 
HETATM 5033 O  O   . HOH T 4 .   ? 8.78302   -17.01842 13.11684  1.000 17.93245  ? 319 HOH G O   1 
HETATM 5034 O  O   . HOH T 4 .   ? 9.197     -3.034    0.638     1.000 16.37884  ? 320 HOH G O   1 
HETATM 5035 O  O   . HOH T 4 .   ? 14.45647  0.42568   2.59277   1.000 23.53028  ? 321 HOH G O   1 
HETATM 5036 O  O   . HOH T 4 .   ? 35.84114  -13.22905 2.63299   1.000 28.21209  ? 322 HOH G O   1 
HETATM 5037 O  O   . HOH T 4 .   ? 30.81226  -17.65346 14.97836  1.000 26.95260  ? 323 HOH G O   1 
HETATM 5038 O  O   . HOH T 4 .   ? 30.75611  -14.94107 -5.20714  1.000 37.02948  ? 324 HOH G O   1 
HETATM 5039 O  O   . HOH T 4 .   ? 23.11669  -26.58405 9.30033   1.000 30.93433  ? 325 HOH G O   1 
HETATM 5040 O  O   . HOH T 4 .   ? 20.06431  -28.53340 5.02515   1.000 29.83358  ? 326 HOH G O   1 
HETATM 5041 O  O   . HOH T 4 .   ? 30.02297  -15.34932 13.78130  1.000 31.62051  ? 327 HOH G O   1 
HETATM 5042 O  O   . HOH T 4 .   ? 30.24403  -20.95581 -0.53506  1.000 38.02804  ? 328 HOH G O   1 
HETATM 5043 O  O   . HOH T 4 .   ? 27.21791  0.91379   4.97995   1.000 34.22811  ? 329 HOH G O   1 
HETATM 5044 O  O   . HOH T 4 .   ? 19.16673  -20.64451 5.76697   1.000 15.85475  ? 330 HOH G O   1 
HETATM 5045 O  O   . HOH T 4 .   ? 23.35825  -25.76150 15.61197  1.000 23.97317  ? 331 HOH G O   1 
HETATM 5046 O  O   . HOH T 4 .   ? 34.29555  -16.21529 6.08916   1.000 21.54949  ? 332 HOH G O   1 
HETATM 5047 O  O   . HOH T 4 .   ? 8.178     -6.387    6.823     1.000 28.74737  ? 333 HOH G O   1 
HETATM 5048 O  O   . HOH T 4 .   ? 6.25960   -14.80334 10.30937  1.000 25.62215  ? 334 HOH G O   1 
HETATM 5049 O  O   . HOH T 4 .   ? 35.32878  -7.00431  3.73677   1.000 18.85633  ? 335 HOH G O   1 
HETATM 5050 O  O   . HOH T 4 .   ? 20.98116  -4.71041  18.36262  1.000 34.45342  ? 336 HOH G O   1 
HETATM 5051 O  O   . HOH T 4 .   ? 21.54136  -27.98696 7.36706   1.000 38.13661  ? 337 HOH G O   1 
HETATM 5052 O  O   . HOH T 4 .   ? 23.77258  -1.50982  -0.50124  1.000 18.89019  ? 338 HOH G O   1 
HETATM 5053 O  O   . HOH T 4 .   ? 17.56277  -24.81468 11.89931  1.000 22.19492  ? 339 HOH G O   1 
HETATM 5054 O  O   . HOH T 4 .   ? 1.69932   -19.07935 17.58500  1.000 38.04031  ? 340 HOH G O   1 
HETATM 5055 O  O   . HOH T 4 .   ? 25.48401  -18.09677 19.37730  1.000 28.70572  ? 341 HOH G O   1 
HETATM 5056 O  O   . HOH T 4 .   ? 16.34359  0.32779   9.45396   1.000 25.69520  ? 342 HOH G O   1 
HETATM 5057 O  O   . HOH T 4 .   ? 38.54834  -4.62774  4.49800   1.000 28.96430  ? 343 HOH G O   1 
HETATM 5058 O  O   . HOH T 4 .   ? 19.26341  -9.17353  17.40968  1.000 16.76259  ? 344 HOH G O   1 
HETATM 5059 O  O   . HOH T 4 .   ? 14.87425  -3.10134  19.61248  1.000 30.64631  ? 345 HOH G O   1 
HETATM 5060 O  O   . HOH T 4 .   ? 1.38733   -12.33719 21.92438  1.000 34.81279  ? 346 HOH G O   1 
HETATM 5061 O  O   . HOH T 4 .   ? 23.70950  -0.29472  -4.56080  1.000 35.08589  ? 347 HOH G O   1 
HETATM 5062 O  O   . HOH T 4 .   ? 36.66618  -11.34056 10.06943  1.000 44.78013  ? 348 HOH G O   1 
HETATM 5063 O  O   . HOH T 4 .   ? 22.84694  -12.27828 19.56708  1.000 18.03255  ? 349 HOH G O   1 
HETATM 5064 O  O   . HOH T 4 .   ? 12.96086  -23.01757 3.73602   1.000 19.46998  ? 350 HOH G O   1 
HETATM 5065 O  O   . HOH T 4 .   ? 14.65679  -7.55150  -4.66476  1.000 27.93310  ? 351 HOH G O   1 
HETATM 5066 O  O   . HOH T 4 .   ? 31.89205  -20.65992 17.21910  1.000 32.14799  ? 352 HOH G O   1 
HETATM 5067 O  O   . HOH T 4 .   ? 21.50062  -21.40300 4.24837   1.000 22.68535  ? 353 HOH G O   1 
HETATM 5068 O  O   . HOH T 4 .   ? 17.79945  -8.65519  22.19788  1.000 34.92259  ? 354 HOH G O   1 
HETATM 5069 O  O   . HOH T 4 .   ? 14.86632  -12.83723 -2.41108  1.000 30.90859  ? 355 HOH G O   1 
HETATM 5070 O  O   . HOH T 4 .   ? 27.63270  2.84610   8.02096   1.000 38.26786  ? 356 HOH G O   1 
HETATM 5071 O  O   . HOH T 4 .   ? 6.11254   -10.65071 16.07480  1.000 32.37787  ? 357 HOH G O   1 
HETATM 5072 O  O   . HOH T 4 .   ? 31.32991  -12.02002 14.34172  1.000 25.17045  ? 358 HOH G O   1 
HETATM 5073 O  O   . HOH T 4 .   ? 17.19443  -10.14925 -3.23675  1.000 27.17512  ? 359 HOH G O   1 
HETATM 5074 O  O   . HOH T 4 .   ? 35.64771  -6.09294  12.32137  1.000 36.81594  ? 360 HOH G O   1 
HETATM 5075 O  O   . HOH T 4 .   ? 35.37541  -10.82301 7.06399   1.000 33.10676  ? 361 HOH G O   1 
HETATM 5076 O  O   . HOH T 4 .   ? 32.68803  -0.15258  -0.69642  1.000 19.26228  ? 362 HOH G O   1 
HETATM 5077 O  O   . HOH T 4 .   ? 11.94304  -16.94607 -2.52955  1.000 33.65193  ? 363 HOH G O   1 
HETATM 5078 O  O   . HOH T 4 .   ? 22.35475  -9.70752  -7.39452  1.000 54.81164  ? 364 HOH G O   1 
HETATM 5079 O  O   . HOH T 4 .   ? 36.04078  -16.62881 10.67024  1.000 33.20328  ? 365 HOH G O   1 
HETATM 5080 O  O   . HOH T 4 .   ? 23.31535  -0.24301  14.96465  1.000 34.99827  ? 366 HOH G O   1 
HETATM 5081 O  O   . HOH T 4 .   ? 36.27347  -11.15228 -0.90639  1.000 34.49369  ? 367 HOH G O   1 
HETATM 5082 O  O   . HOH T 4 .   ? 35.19015  -6.34895  9.35448   1.000 22.56548  ? 368 HOH G O   1 
HETATM 5083 O  O   . HOH T 4 .   ? 29.39458  -23.24092 18.35038  1.000 25.78722  ? 369 HOH G O   1 
HETATM 5084 O  O   . HOH T 4 .   ? 14.03609  -11.45437 -3.95679  1.000 51.86652  ? 370 HOH G O   1 
HETATM 5085 O  O   . HOH T 4 .   ? 19.78737  0.48446   10.21286  1.000 29.56513  ? 371 HOH G O   1 
HETATM 5086 O  O   . HOH T 4 .   ? 14.56600  -18.61960 0.45215   1.000 25.72930  ? 372 HOH G O   1 
HETATM 5087 O  O   . HOH T 4 .   ? 25.93824  -2.13323  11.85094  1.000 33.71498  ? 373 HOH G O   1 
HETATM 5088 O  O   . HOH T 4 .   ? 3.48083   -14.95856 30.09872  1.000 42.04081  ? 374 HOH G O   1 
HETATM 5089 O  O   . HOH T 4 .   ? 23.21087  -15.61424 20.44698  1.000 21.32488  ? 375 HOH G O   1 
HETATM 5090 O  O   . HOH T 4 .   ? 34.92462  -17.62106 2.12779   1.000 43.34356  ? 376 HOH G O   1 
HETATM 5091 O  O   . HOH T 4 .   ? 12.98430  -21.52743 1.55052   1.000 37.46505  ? 377 HOH G O   1 
HETATM 5092 O  O   . HOH T 4 .   ? 13.99475  -16.27054 -0.94686  1.000 30.41900  ? 378 HOH G O   1 
HETATM 5093 O  O   . HOH T 4 .   ? 24.74276  -10.67584 20.33694  1.000 29.58225  ? 379 HOH G O   1 
HETATM 5094 O  O   . HOH T 4 .   ? 19.56810  -11.45719 29.41578  1.000 35.93946  ? 380 HOH G O   1 
HETATM 5095 O  O   . HOH T 4 .   ? 29.17912  -20.90659 4.90174   1.000 40.92777  ? 381 HOH G O   1 
HETATM 5096 O  O   . HOH T 4 .   ? 6.14161   -16.05866 12.73661  1.000 30.52430  ? 382 HOH G O   1 
HETATM 5097 O  O   . HOH T 4 .   ? 27.84959  -24.63374 9.74419   1.000 38.43479  ? 383 HOH G O   1 
HETATM 5098 O  O   . HOH T 4 .   ? 21.68617  -26.85822 13.30190  1.000 33.24138  ? 384 HOH G O   1 
HETATM 5099 O  O   . HOH T 4 .   ? 21.16623  1.71490   1.59858   1.000 37.89611  ? 385 HOH G O   1 
HETATM 5100 O  O   . HOH T 4 .   ? 20.64432  -10.61902 19.68556  1.000 22.24067  ? 386 HOH G O   1 
HETATM 5101 O  O   . HOH T 4 .   ? 26.32957  -25.63308 21.11999  1.000 41.70032  ? 387 HOH G O   1 
HETATM 5102 O  O   . HOH T 4 .   ? 34.27987  -18.76133 5.68452   1.000 50.99273  ? 388 HOH G O   1 
HETATM 5103 O  O   . HOH T 4 .   ? 10.826    -2.823    -1.707    1.000 19.27829  ? 389 HOH G O   1 
HETATM 5104 O  O   . HOH T 4 .   ? -2.60249  -21.95162 20.13023  1.000 42.42029  ? 390 HOH G O   1 
HETATM 5105 O  O   . HOH T 4 .   ? 37.29985  -9.80201  1.38048   1.000 27.39564  ? 391 HOH G O   1 
HETATM 5106 O  O   . HOH T 4 .   ? 9.99365   -17.83399 -2.03659  1.000 50.23677  ? 392 HOH G O   1 
HETATM 5107 O  O   . HOH T 4 .   ? 35.92765  -15.51359 4.04616   1.000 29.40296  ? 393 HOH G O   1 
HETATM 5108 O  O   . HOH T 4 .   ? 20.04650  -7.28896  19.48079  1.000 28.35634  ? 394 HOH G O   1 
# 
