data_9KRG
# 
_entry.id   9KRG 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9KRG         pdb_00009krg 10.2210/pdb9krg/pdb 
WWPDB D_1300054051 ?            ?                   
EMDB  EMD-62526    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-15 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9KRG 
_pdbx_database_status.recvd_initial_deposition_date   2024-11-27 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB  'Protomer atomic model'                          9KOM      unspecified            
EMDB 'Protomer-focused EM map'                        EMD-62478 'other EM volume'      
EMDB 'Cryo-EM structure of human pannexin-3 heptamer' EMD-62526 'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              yokoken@cc.kyoto-su.ac.jp 
_pdbx_contact_author.name_first         Ken 
_pdbx_contact_author.name_last          Yokoyama 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-6813-1096 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Tsuyama, T.'  1 0000-0001-5860-6396 
'Yokoyama, K.' 2 0000-0002-6813-1096 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Biochem.Biophys.Res.Commun. 
_citation.journal_id_ASTM           BBRCA9 
_citation.journal_id_CSD            0146 
_citation.journal_id_ISSN           1090-2104 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            745 
_citation.language                  ? 
_citation.page_first                151227 
_citation.page_last                 151227 
_citation.title                     'Cryo-EM structure of the human Pannexin-3 channel.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.bbrc.2024.151227 
_citation.pdbx_database_id_PubMed   39721314 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Tsuyama, T.'     1 ? 
primary 'Teramura, R.'    2 ? 
primary 'Mitsuoka, K.'    3 ? 
primary 'Kishikawa, J.I.' 4 ? 
primary 'Yokoyama, K.'    5 ? 
# 
_entity.id                         1 
_entity.type                       polymer 
_entity.src_method                 man 
_entity.pdbx_description           Pannexin-3 
_entity.formula_weight             45965.449 
_entity.pdbx_number_of_molecules   1 
_entity.pdbx_ec                    ? 
_entity.pdbx_mutation              ? 
_entity.pdbx_fragment              ? 
_entity.details                    ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MSLAHTAAEYMLSDALLPDRRGPRLKGLRLELPLDRIVKFVAVGSPLLLMSLAFAQEFSSGSPISCFSPSNFSIRQAAYV
DSSCWDSLLHHKQDGPGQDKMKSLWPHKALPYSLLALALLMYLPVLLWQYAAVPALSSDLLFIISELDKSYNRSIRLVQH
MLKIRQKSSDPYVFWNELEKARKERYFEFPLLERYLACKQRSHSLVATYLLRNSLLLIFTSATYLYLGHFHLDVFFQEEF
SCSIKTGLLSDETHVPNLITCRLTSLSIFQIVSLSSVAIYTILVPVIIYNLTRLCRWDKRLLSVYEMLPAFDLLSRKMLG
CPINDLNVILLFLRANISELISFSWLSVLCVLKDTTTQKHNIDTVVDFMTLLAGLEPSKPKHLTNSACDEHPGSGGSGHH
HHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MSLAHTAAEYMLSDALLPDRRGPRLKGLRLELPLDRIVKFVAVGSPLLLMSLAFAQEFSSGSPISCFSPSNFSIRQAAYV
DSSCWDSLLHHKQDGPGQDKMKSLWPHKALPYSLLALALLMYLPVLLWQYAAVPALSSDLLFIISELDKSYNRSIRLVQH
MLKIRQKSSDPYVFWNELEKARKERYFEFPLLERYLACKQRSHSLVATYLLRNSLLLIFTSATYLYLGHFHLDVFFQEEF
SCSIKTGLLSDETHVPNLITCRLTSLSIFQIVSLSSVAIYTILVPVIIYNLTRLCRWDKRLLSVYEMLPAFDLLSRKMLG
CPINDLNVILLFLRANISELISFSWLSVLCVLKDTTTQKHNIDTVVDFMTLLAGLEPSKPKHLTNSACDEHPGSGGSGHH
HHHH
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   SER n 
1 3   LEU n 
1 4   ALA n 
1 5   HIS n 
1 6   THR n 
1 7   ALA n 
1 8   ALA n 
1 9   GLU n 
1 10  TYR n 
1 11  MET n 
1 12  LEU n 
1 13  SER n 
1 14  ASP n 
1 15  ALA n 
1 16  LEU n 
1 17  LEU n 
1 18  PRO n 
1 19  ASP n 
1 20  ARG n 
1 21  ARG n 
1 22  GLY n 
1 23  PRO n 
1 24  ARG n 
1 25  LEU n 
1 26  LYS n 
1 27  GLY n 
1 28  LEU n 
1 29  ARG n 
1 30  LEU n 
1 31  GLU n 
1 32  LEU n 
1 33  PRO n 
1 34  LEU n 
1 35  ASP n 
1 36  ARG n 
1 37  ILE n 
1 38  VAL n 
1 39  LYS n 
1 40  PHE n 
1 41  VAL n 
1 42  ALA n 
1 43  VAL n 
1 44  GLY n 
1 45  SER n 
1 46  PRO n 
1 47  LEU n 
1 48  LEU n 
1 49  LEU n 
1 50  MET n 
1 51  SER n 
1 52  LEU n 
1 53  ALA n 
1 54  PHE n 
1 55  ALA n 
1 56  GLN n 
1 57  GLU n 
1 58  PHE n 
1 59  SER n 
1 60  SER n 
1 61  GLY n 
1 62  SER n 
1 63  PRO n 
1 64  ILE n 
1 65  SER n 
1 66  CYS n 
1 67  PHE n 
1 68  SER n 
1 69  PRO n 
1 70  SER n 
1 71  ASN n 
1 72  PHE n 
1 73  SER n 
1 74  ILE n 
1 75  ARG n 
1 76  GLN n 
1 77  ALA n 
1 78  ALA n 
1 79  TYR n 
1 80  VAL n 
1 81  ASP n 
1 82  SER n 
1 83  SER n 
1 84  CYS n 
1 85  TRP n 
1 86  ASP n 
1 87  SER n 
1 88  LEU n 
1 89  LEU n 
1 90  HIS n 
1 91  HIS n 
1 92  LYS n 
1 93  GLN n 
1 94  ASP n 
1 95  GLY n 
1 96  PRO n 
1 97  GLY n 
1 98  GLN n 
1 99  ASP n 
1 100 LYS n 
1 101 MET n 
1 102 LYS n 
1 103 SER n 
1 104 LEU n 
1 105 TRP n 
1 106 PRO n 
1 107 HIS n 
1 108 LYS n 
1 109 ALA n 
1 110 LEU n 
1 111 PRO n 
1 112 TYR n 
1 113 SER n 
1 114 LEU n 
1 115 LEU n 
1 116 ALA n 
1 117 LEU n 
1 118 ALA n 
1 119 LEU n 
1 120 LEU n 
1 121 MET n 
1 122 TYR n 
1 123 LEU n 
1 124 PRO n 
1 125 VAL n 
1 126 LEU n 
1 127 LEU n 
1 128 TRP n 
1 129 GLN n 
1 130 TYR n 
1 131 ALA n 
1 132 ALA n 
1 133 VAL n 
1 134 PRO n 
1 135 ALA n 
1 136 LEU n 
1 137 SER n 
1 138 SER n 
1 139 ASP n 
1 140 LEU n 
1 141 LEU n 
1 142 PHE n 
1 143 ILE n 
1 144 ILE n 
1 145 SER n 
1 146 GLU n 
1 147 LEU n 
1 148 ASP n 
1 149 LYS n 
1 150 SER n 
1 151 TYR n 
1 152 ASN n 
1 153 ARG n 
1 154 SER n 
1 155 ILE n 
1 156 ARG n 
1 157 LEU n 
1 158 VAL n 
1 159 GLN n 
1 160 HIS n 
1 161 MET n 
1 162 LEU n 
1 163 LYS n 
1 164 ILE n 
1 165 ARG n 
1 166 GLN n 
1 167 LYS n 
1 168 SER n 
1 169 SER n 
1 170 ASP n 
1 171 PRO n 
1 172 TYR n 
1 173 VAL n 
1 174 PHE n 
1 175 TRP n 
1 176 ASN n 
1 177 GLU n 
1 178 LEU n 
1 179 GLU n 
1 180 LYS n 
1 181 ALA n 
1 182 ARG n 
1 183 LYS n 
1 184 GLU n 
1 185 ARG n 
1 186 TYR n 
1 187 PHE n 
1 188 GLU n 
1 189 PHE n 
1 190 PRO n 
1 191 LEU n 
1 192 LEU n 
1 193 GLU n 
1 194 ARG n 
1 195 TYR n 
1 196 LEU n 
1 197 ALA n 
1 198 CYS n 
1 199 LYS n 
1 200 GLN n 
1 201 ARG n 
1 202 SER n 
1 203 HIS n 
1 204 SER n 
1 205 LEU n 
1 206 VAL n 
1 207 ALA n 
1 208 THR n 
1 209 TYR n 
1 210 LEU n 
1 211 LEU n 
1 212 ARG n 
1 213 ASN n 
1 214 SER n 
1 215 LEU n 
1 216 LEU n 
1 217 LEU n 
1 218 ILE n 
1 219 PHE n 
1 220 THR n 
1 221 SER n 
1 222 ALA n 
1 223 THR n 
1 224 TYR n 
1 225 LEU n 
1 226 TYR n 
1 227 LEU n 
1 228 GLY n 
1 229 HIS n 
1 230 PHE n 
1 231 HIS n 
1 232 LEU n 
1 233 ASP n 
1 234 VAL n 
1 235 PHE n 
1 236 PHE n 
1 237 GLN n 
1 238 GLU n 
1 239 GLU n 
1 240 PHE n 
1 241 SER n 
1 242 CYS n 
1 243 SER n 
1 244 ILE n 
1 245 LYS n 
1 246 THR n 
1 247 GLY n 
1 248 LEU n 
1 249 LEU n 
1 250 SER n 
1 251 ASP n 
1 252 GLU n 
1 253 THR n 
1 254 HIS n 
1 255 VAL n 
1 256 PRO n 
1 257 ASN n 
1 258 LEU n 
1 259 ILE n 
1 260 THR n 
1 261 CYS n 
1 262 ARG n 
1 263 LEU n 
1 264 THR n 
1 265 SER n 
1 266 LEU n 
1 267 SER n 
1 268 ILE n 
1 269 PHE n 
1 270 GLN n 
1 271 ILE n 
1 272 VAL n 
1 273 SER n 
1 274 LEU n 
1 275 SER n 
1 276 SER n 
1 277 VAL n 
1 278 ALA n 
1 279 ILE n 
1 280 TYR n 
1 281 THR n 
1 282 ILE n 
1 283 LEU n 
1 284 VAL n 
1 285 PRO n 
1 286 VAL n 
1 287 ILE n 
1 288 ILE n 
1 289 TYR n 
1 290 ASN n 
1 291 LEU n 
1 292 THR n 
1 293 ARG n 
1 294 LEU n 
1 295 CYS n 
1 296 ARG n 
1 297 TRP n 
1 298 ASP n 
1 299 LYS n 
1 300 ARG n 
1 301 LEU n 
1 302 LEU n 
1 303 SER n 
1 304 VAL n 
1 305 TYR n 
1 306 GLU n 
1 307 MET n 
1 308 LEU n 
1 309 PRO n 
1 310 ALA n 
1 311 PHE n 
1 312 ASP n 
1 313 LEU n 
1 314 LEU n 
1 315 SER n 
1 316 ARG n 
1 317 LYS n 
1 318 MET n 
1 319 LEU n 
1 320 GLY n 
1 321 CYS n 
1 322 PRO n 
1 323 ILE n 
1 324 ASN n 
1 325 ASP n 
1 326 LEU n 
1 327 ASN n 
1 328 VAL n 
1 329 ILE n 
1 330 LEU n 
1 331 LEU n 
1 332 PHE n 
1 333 LEU n 
1 334 ARG n 
1 335 ALA n 
1 336 ASN n 
1 337 ILE n 
1 338 SER n 
1 339 GLU n 
1 340 LEU n 
1 341 ILE n 
1 342 SER n 
1 343 PHE n 
1 344 SER n 
1 345 TRP n 
1 346 LEU n 
1 347 SER n 
1 348 VAL n 
1 349 LEU n 
1 350 CYS n 
1 351 VAL n 
1 352 LEU n 
1 353 LYS n 
1 354 ASP n 
1 355 THR n 
1 356 THR n 
1 357 THR n 
1 358 GLN n 
1 359 LYS n 
1 360 HIS n 
1 361 ASN n 
1 362 ILE n 
1 363 ASP n 
1 364 THR n 
1 365 VAL n 
1 366 VAL n 
1 367 ASP n 
1 368 PHE n 
1 369 MET n 
1 370 THR n 
1 371 LEU n 
1 372 LEU n 
1 373 ALA n 
1 374 GLY n 
1 375 LEU n 
1 376 GLU n 
1 377 PRO n 
1 378 SER n 
1 379 LYS n 
1 380 PRO n 
1 381 LYS n 
1 382 HIS n 
1 383 LEU n 
1 384 THR n 
1 385 ASN n 
1 386 SER n 
1 387 ALA n 
1 388 CYS n 
1 389 ASP n 
1 390 GLU n 
1 391 HIS n 
1 392 PRO n 
1 393 GLY n 
1 394 SER n 
1 395 GLY n 
1 396 GLY n 
1 397 SER n 
1 398 GLY n 
1 399 HIS n 
1 400 HIS n 
1 401 HIS n 
1 402 HIS n 
1 403 HIS n 
1 404 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   404 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 PANX3 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            'Expi293F cell' 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       pcDNA3.4 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   SER 2   2   ?   ?   ?   A . n 
A 1 3   LEU 3   3   ?   ?   ?   A . n 
A 1 4   ALA 4   4   ?   ?   ?   A . n 
A 1 5   HIS 5   5   ?   ?   ?   A . n 
A 1 6   THR 6   6   ?   ?   ?   A . n 
A 1 7   ALA 7   7   ?   ?   ?   A . n 
A 1 8   ALA 8   8   ?   ?   ?   A . n 
A 1 9   GLU 9   9   ?   ?   ?   A . n 
A 1 10  TYR 10  10  ?   ?   ?   A . n 
A 1 11  MET 11  11  ?   ?   ?   A . n 
A 1 12  LEU 12  12  ?   ?   ?   A . n 
A 1 13  SER 13  13  ?   ?   ?   A . n 
A 1 14  ASP 14  14  ?   ?   ?   A . n 
A 1 15  ALA 15  15  ?   ?   ?   A . n 
A 1 16  LEU 16  16  ?   ?   ?   A . n 
A 1 17  LEU 17  17  ?   ?   ?   A . n 
A 1 18  PRO 18  18  ?   ?   ?   A . n 
A 1 19  ASP 19  19  ?   ?   ?   A . n 
A 1 20  ARG 20  20  ?   ?   ?   A . n 
A 1 21  ARG 21  21  ?   ?   ?   A . n 
A 1 22  GLY 22  22  ?   ?   ?   A . n 
A 1 23  PRO 23  23  ?   ?   ?   A . n 
A 1 24  ARG 24  24  ?   ?   ?   A . n 
A 1 25  LEU 25  25  ?   ?   ?   A . n 
A 1 26  LYS 26  26  ?   ?   ?   A . n 
A 1 27  GLY 27  27  27  GLY GLY A . n 
A 1 28  LEU 28  28  28  LEU LEU A . n 
A 1 29  ARG 29  29  29  ARG ARG A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  GLU 31  31  31  GLU GLU A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  PRO 33  33  33  PRO PRO A . n 
A 1 34  LEU 34  34  34  LEU LEU A . n 
A 1 35  ASP 35  35  35  ASP ASP A . n 
A 1 36  ARG 36  36  36  ARG ARG A . n 
A 1 37  ILE 37  37  37  ILE ILE A . n 
A 1 38  VAL 38  38  38  VAL VAL A . n 
A 1 39  LYS 39  39  39  LYS LYS A . n 
A 1 40  PHE 40  40  40  PHE PHE A . n 
A 1 41  VAL 41  41  41  VAL VAL A . n 
A 1 42  ALA 42  42  42  ALA ALA A . n 
A 1 43  VAL 43  43  43  VAL VAL A . n 
A 1 44  GLY 44  44  44  GLY GLY A . n 
A 1 45  SER 45  45  45  SER SER A . n 
A 1 46  PRO 46  46  46  PRO PRO A . n 
A 1 47  LEU 47  47  47  LEU LEU A . n 
A 1 48  LEU 48  48  48  LEU LEU A . n 
A 1 49  LEU 49  49  49  LEU LEU A . n 
A 1 50  MET 50  50  50  MET MET A . n 
A 1 51  SER 51  51  51  SER SER A . n 
A 1 52  LEU 52  52  52  LEU LEU A . n 
A 1 53  ALA 53  53  53  ALA ALA A . n 
A 1 54  PHE 54  54  54  PHE PHE A . n 
A 1 55  ALA 55  55  55  ALA ALA A . n 
A 1 56  GLN 56  56  56  GLN GLN A . n 
A 1 57  GLU 57  57  57  GLU GLU A . n 
A 1 58  PHE 58  58  58  PHE PHE A . n 
A 1 59  SER 59  59  59  SER SER A . n 
A 1 60  SER 60  60  60  SER SER A . n 
A 1 61  GLY 61  61  61  GLY GLY A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  PRO 63  63  63  PRO PRO A . n 
A 1 64  ILE 64  64  64  ILE ILE A . n 
A 1 65  SER 65  65  65  SER SER A . n 
A 1 66  CYS 66  66  66  CYS CYS A . n 
A 1 67  PHE 67  67  67  PHE PHE A . n 
A 1 68  SER 68  68  68  SER SER A . n 
A 1 69  PRO 69  69  69  PRO PRO A . n 
A 1 70  SER 70  70  70  SER SER A . n 
A 1 71  ASN 71  71  71  ASN ASN A . n 
A 1 72  PHE 72  72  72  PHE PHE A . n 
A 1 73  SER 73  73  73  SER SER A . n 
A 1 74  ILE 74  74  74  ILE ILE A . n 
A 1 75  ARG 75  75  75  ARG ARG A . n 
A 1 76  GLN 76  76  76  GLN GLN A . n 
A 1 77  ALA 77  77  77  ALA ALA A . n 
A 1 78  ALA 78  78  78  ALA ALA A . n 
A 1 79  TYR 79  79  79  TYR TYR A . n 
A 1 80  VAL 80  80  80  VAL VAL A . n 
A 1 81  ASP 81  81  81  ASP ASP A . n 
A 1 82  SER 82  82  82  SER SER A . n 
A 1 83  SER 83  83  83  SER SER A . n 
A 1 84  CYS 84  84  84  CYS CYS A . n 
A 1 85  TRP 85  85  85  TRP TRP A . n 
A 1 86  ASP 86  86  86  ASP ASP A . n 
A 1 87  SER 87  87  87  SER SER A . n 
A 1 88  LEU 88  88  88  LEU LEU A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  HIS 90  90  90  HIS HIS A . n 
A 1 91  HIS 91  91  91  HIS HIS A . n 
A 1 92  LYS 92  92  92  LYS LYS A . n 
A 1 93  GLN 93  93  ?   ?   ?   A . n 
A 1 94  ASP 94  94  ?   ?   ?   A . n 
A 1 95  GLY 95  95  ?   ?   ?   A . n 
A 1 96  PRO 96  96  ?   ?   ?   A . n 
A 1 97  GLY 97  97  ?   ?   ?   A . n 
A 1 98  GLN 98  98  ?   ?   ?   A . n 
A 1 99  ASP 99  99  ?   ?   ?   A . n 
A 1 100 LYS 100 100 ?   ?   ?   A . n 
A 1 101 MET 101 101 ?   ?   ?   A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 SER 103 103 103 SER SER A . n 
A 1 104 LEU 104 104 104 LEU LEU A . n 
A 1 105 TRP 105 105 105 TRP TRP A . n 
A 1 106 PRO 106 106 106 PRO PRO A . n 
A 1 107 HIS 107 107 107 HIS HIS A . n 
A 1 108 LYS 108 108 108 LYS LYS A . n 
A 1 109 ALA 109 109 109 ALA ALA A . n 
A 1 110 LEU 110 110 110 LEU LEU A . n 
A 1 111 PRO 111 111 111 PRO PRO A . n 
A 1 112 TYR 112 112 112 TYR TYR A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 LEU 114 114 114 LEU LEU A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 LEU 117 117 117 LEU LEU A . n 
A 1 118 ALA 118 118 118 ALA ALA A . n 
A 1 119 LEU 119 119 119 LEU LEU A . n 
A 1 120 LEU 120 120 120 LEU LEU A . n 
A 1 121 MET 121 121 121 MET MET A . n 
A 1 122 TYR 122 122 122 TYR TYR A . n 
A 1 123 LEU 123 123 123 LEU LEU A . n 
A 1 124 PRO 124 124 124 PRO PRO A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 LEU 126 126 126 LEU LEU A . n 
A 1 127 LEU 127 127 127 LEU LEU A . n 
A 1 128 TRP 128 128 128 TRP TRP A . n 
A 1 129 GLN 129 129 129 GLN GLN A . n 
A 1 130 TYR 130 130 130 TYR TYR A . n 
A 1 131 ALA 131 131 131 ALA ALA A . n 
A 1 132 ALA 132 132 132 ALA ALA A . n 
A 1 133 VAL 133 133 133 VAL VAL A . n 
A 1 134 PRO 134 134 134 PRO PRO A . n 
A 1 135 ALA 135 135 135 ALA ALA A . n 
A 1 136 LEU 136 136 136 LEU LEU A . n 
A 1 137 SER 137 137 137 SER SER A . n 
A 1 138 SER 138 138 138 SER SER A . n 
A 1 139 ASP 139 139 139 ASP ASP A . n 
A 1 140 LEU 140 140 140 LEU LEU A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 PHE 142 142 142 PHE PHE A . n 
A 1 143 ILE 143 143 143 ILE ILE A . n 
A 1 144 ILE 144 144 144 ILE ILE A . n 
A 1 145 SER 145 145 145 SER SER A . n 
A 1 146 GLU 146 146 146 GLU GLU A . n 
A 1 147 LEU 147 147 147 LEU LEU A . n 
A 1 148 ASP 148 148 148 ASP ASP A . n 
A 1 149 LYS 149 149 149 LYS LYS A . n 
A 1 150 SER 150 150 150 SER SER A . n 
A 1 151 TYR 151 151 151 TYR TYR A . n 
A 1 152 ASN 152 152 152 ASN ASN A . n 
A 1 153 ARG 153 153 153 ARG ARG A . n 
A 1 154 SER 154 154 154 SER SER A . n 
A 1 155 ILE 155 155 155 ILE ILE A . n 
A 1 156 ARG 156 156 156 ARG ARG A . n 
A 1 157 LEU 157 157 157 LEU LEU A . n 
A 1 158 VAL 158 158 158 VAL VAL A . n 
A 1 159 GLN 159 159 159 GLN GLN A . n 
A 1 160 HIS 160 160 160 HIS HIS A . n 
A 1 161 MET 161 161 ?   ?   ?   A . n 
A 1 162 LEU 162 162 ?   ?   ?   A . n 
A 1 163 LYS 163 163 ?   ?   ?   A . n 
A 1 164 ILE 164 164 ?   ?   ?   A . n 
A 1 165 ARG 165 165 ?   ?   ?   A . n 
A 1 166 GLN 166 166 ?   ?   ?   A . n 
A 1 167 LYS 167 167 ?   ?   ?   A . n 
A 1 168 SER 168 168 ?   ?   ?   A . n 
A 1 169 SER 169 169 ?   ?   ?   A . n 
A 1 170 ASP 170 170 ?   ?   ?   A . n 
A 1 171 PRO 171 171 ?   ?   ?   A . n 
A 1 172 TYR 172 172 ?   ?   ?   A . n 
A 1 173 VAL 173 173 ?   ?   ?   A . n 
A 1 174 PHE 174 174 ?   ?   ?   A . n 
A 1 175 TRP 175 175 ?   ?   ?   A . n 
A 1 176 ASN 176 176 ?   ?   ?   A . n 
A 1 177 GLU 177 177 ?   ?   ?   A . n 
A 1 178 LEU 178 178 ?   ?   ?   A . n 
A 1 179 GLU 179 179 ?   ?   ?   A . n 
A 1 180 LYS 180 180 ?   ?   ?   A . n 
A 1 181 ALA 181 181 ?   ?   ?   A . n 
A 1 182 ARG 182 182 ?   ?   ?   A . n 
A 1 183 LYS 183 183 183 LYS LYS A . n 
A 1 184 GLU 184 184 184 GLU GLU A . n 
A 1 185 ARG 185 185 185 ARG ARG A . n 
A 1 186 TYR 186 186 186 TYR TYR A . n 
A 1 187 PHE 187 187 187 PHE PHE A . n 
A 1 188 GLU 188 188 188 GLU GLU A . n 
A 1 189 PHE 189 189 189 PHE PHE A . n 
A 1 190 PRO 190 190 190 PRO PRO A . n 
A 1 191 LEU 191 191 191 LEU LEU A . n 
A 1 192 LEU 192 192 192 LEU LEU A . n 
A 1 193 GLU 193 193 193 GLU GLU A . n 
A 1 194 ARG 194 194 194 ARG ARG A . n 
A 1 195 TYR 195 195 195 TYR TYR A . n 
A 1 196 LEU 196 196 196 LEU LEU A . n 
A 1 197 ALA 197 197 197 ALA ALA A . n 
A 1 198 CYS 198 198 198 CYS CYS A . n 
A 1 199 LYS 199 199 199 LYS LYS A . n 
A 1 200 GLN 200 200 200 GLN GLN A . n 
A 1 201 ARG 201 201 201 ARG ARG A . n 
A 1 202 SER 202 202 202 SER SER A . n 
A 1 203 HIS 203 203 203 HIS HIS A . n 
A 1 204 SER 204 204 204 SER SER A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 VAL 206 206 206 VAL VAL A . n 
A 1 207 ALA 207 207 207 ALA ALA A . n 
A 1 208 THR 208 208 208 THR THR A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 LEU 210 210 210 LEU LEU A . n 
A 1 211 LEU 211 211 211 LEU LEU A . n 
A 1 212 ARG 212 212 212 ARG ARG A . n 
A 1 213 ASN 213 213 213 ASN ASN A . n 
A 1 214 SER 214 214 214 SER SER A . n 
A 1 215 LEU 215 215 215 LEU LEU A . n 
A 1 216 LEU 216 216 216 LEU LEU A . n 
A 1 217 LEU 217 217 217 LEU LEU A . n 
A 1 218 ILE 218 218 218 ILE ILE A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 THR 220 220 220 THR THR A . n 
A 1 221 SER 221 221 221 SER SER A . n 
A 1 222 ALA 222 222 222 ALA ALA A . n 
A 1 223 THR 223 223 223 THR THR A . n 
A 1 224 TYR 224 224 224 TYR TYR A . n 
A 1 225 LEU 225 225 225 LEU LEU A . n 
A 1 226 TYR 226 226 226 TYR TYR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 GLY 228 228 228 GLY GLY A . n 
A 1 229 HIS 229 229 229 HIS HIS A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 HIS 231 231 231 HIS HIS A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 ASP 233 233 233 ASP ASP A . n 
A 1 234 VAL 234 234 234 VAL VAL A . n 
A 1 235 PHE 235 235 235 PHE PHE A . n 
A 1 236 PHE 236 236 236 PHE PHE A . n 
A 1 237 GLN 237 237 237 GLN GLN A . n 
A 1 238 GLU 238 238 238 GLU GLU A . n 
A 1 239 GLU 239 239 239 GLU GLU A . n 
A 1 240 PHE 240 240 240 PHE PHE A . n 
A 1 241 SER 241 241 241 SER SER A . n 
A 1 242 CYS 242 242 242 CYS CYS A . n 
A 1 243 SER 243 243 243 SER SER A . n 
A 1 244 ILE 244 244 244 ILE ILE A . n 
A 1 245 LYS 245 245 245 LYS LYS A . n 
A 1 246 THR 246 246 246 THR THR A . n 
A 1 247 GLY 247 247 247 GLY GLY A . n 
A 1 248 LEU 248 248 248 LEU LEU A . n 
A 1 249 LEU 249 249 249 LEU LEU A . n 
A 1 250 SER 250 250 250 SER SER A . n 
A 1 251 ASP 251 251 251 ASP ASP A . n 
A 1 252 GLU 252 252 252 GLU GLU A . n 
A 1 253 THR 253 253 253 THR THR A . n 
A 1 254 HIS 254 254 254 HIS HIS A . n 
A 1 255 VAL 255 255 255 VAL VAL A . n 
A 1 256 PRO 256 256 256 PRO PRO A . n 
A 1 257 ASN 257 257 257 ASN ASN A . n 
A 1 258 LEU 258 258 258 LEU LEU A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 THR 260 260 260 THR THR A . n 
A 1 261 CYS 261 261 261 CYS CYS A . n 
A 1 262 ARG 262 262 262 ARG ARG A . n 
A 1 263 LEU 263 263 263 LEU LEU A . n 
A 1 264 THR 264 264 264 THR THR A . n 
A 1 265 SER 265 265 265 SER SER A . n 
A 1 266 LEU 266 266 266 LEU LEU A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 ILE 268 268 268 ILE ILE A . n 
A 1 269 PHE 269 269 269 PHE PHE A . n 
A 1 270 GLN 270 270 270 GLN GLN A . n 
A 1 271 ILE 271 271 271 ILE ILE A . n 
A 1 272 VAL 272 272 272 VAL VAL A . n 
A 1 273 SER 273 273 273 SER SER A . n 
A 1 274 LEU 274 274 274 LEU LEU A . n 
A 1 275 SER 275 275 275 SER SER A . n 
A 1 276 SER 276 276 276 SER SER A . n 
A 1 277 VAL 277 277 277 VAL VAL A . n 
A 1 278 ALA 278 278 278 ALA ALA A . n 
A 1 279 ILE 279 279 279 ILE ILE A . n 
A 1 280 TYR 280 280 280 TYR TYR A . n 
A 1 281 THR 281 281 281 THR THR A . n 
A 1 282 ILE 282 282 282 ILE ILE A . n 
A 1 283 LEU 283 283 283 LEU LEU A . n 
A 1 284 VAL 284 284 284 VAL VAL A . n 
A 1 285 PRO 285 285 285 PRO PRO A . n 
A 1 286 VAL 286 286 286 VAL VAL A . n 
A 1 287 ILE 287 287 287 ILE ILE A . n 
A 1 288 ILE 288 288 288 ILE ILE A . n 
A 1 289 TYR 289 289 289 TYR TYR A . n 
A 1 290 ASN 290 290 290 ASN ASN A . n 
A 1 291 LEU 291 291 291 LEU LEU A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 ARG 293 293 293 ARG ARG A . n 
A 1 294 LEU 294 294 294 LEU LEU A . n 
A 1 295 CYS 295 295 295 CYS CYS A . n 
A 1 296 ARG 296 296 296 ARG ARG A . n 
A 1 297 TRP 297 297 297 TRP TRP A . n 
A 1 298 ASP 298 298 298 ASP ASP A . n 
A 1 299 LYS 299 299 299 LYS LYS A . n 
A 1 300 ARG 300 300 300 ARG ARG A . n 
A 1 301 LEU 301 301 ?   ?   ?   A . n 
A 1 302 LEU 302 302 ?   ?   ?   A . n 
A 1 303 SER 303 303 ?   ?   ?   A . n 
A 1 304 VAL 304 304 ?   ?   ?   A . n 
A 1 305 TYR 305 305 ?   ?   ?   A . n 
A 1 306 GLU 306 306 ?   ?   ?   A . n 
A 1 307 MET 307 307 ?   ?   ?   A . n 
A 1 308 LEU 308 308 ?   ?   ?   A . n 
A 1 309 PRO 309 309 309 PRO PRO A . n 
A 1 310 ALA 310 310 310 ALA ALA A . n 
A 1 311 PHE 311 311 311 PHE PHE A . n 
A 1 312 ASP 312 312 312 ASP ASP A . n 
A 1 313 LEU 313 313 313 LEU LEU A . n 
A 1 314 LEU 314 314 314 LEU LEU A . n 
A 1 315 SER 315 315 315 SER SER A . n 
A 1 316 ARG 316 316 316 ARG ARG A . n 
A 1 317 LYS 317 317 317 LYS LYS A . n 
A 1 318 MET 318 318 318 MET MET A . n 
A 1 319 LEU 319 319 319 LEU LEU A . n 
A 1 320 GLY 320 320 320 GLY GLY A . n 
A 1 321 CYS 321 321 321 CYS CYS A . n 
A 1 322 PRO 322 322 322 PRO PRO A . n 
A 1 323 ILE 323 323 323 ILE ILE A . n 
A 1 324 ASN 324 324 324 ASN ASN A . n 
A 1 325 ASP 325 325 325 ASP ASP A . n 
A 1 326 LEU 326 326 326 LEU LEU A . n 
A 1 327 ASN 327 327 327 ASN ASN A . n 
A 1 328 VAL 328 328 328 VAL VAL A . n 
A 1 329 ILE 329 329 329 ILE ILE A . n 
A 1 330 LEU 330 330 330 LEU LEU A . n 
A 1 331 LEU 331 331 331 LEU LEU A . n 
A 1 332 PHE 332 332 332 PHE PHE A . n 
A 1 333 LEU 333 333 333 LEU LEU A . n 
A 1 334 ARG 334 334 334 ARG ARG A . n 
A 1 335 ALA 335 335 335 ALA ALA A . n 
A 1 336 ASN 336 336 336 ASN ASN A . n 
A 1 337 ILE 337 337 337 ILE ILE A . n 
A 1 338 SER 338 338 338 SER SER A . n 
A 1 339 GLU 339 339 339 GLU GLU A . n 
A 1 340 LEU 340 340 340 LEU LEU A . n 
A 1 341 ILE 341 341 341 ILE ILE A . n 
A 1 342 SER 342 342 342 SER SER A . n 
A 1 343 PHE 343 343 343 PHE PHE A . n 
A 1 344 SER 344 344 344 SER SER A . n 
A 1 345 TRP 345 345 345 TRP TRP A . n 
A 1 346 LEU 346 346 346 LEU LEU A . n 
A 1 347 SER 347 347 347 SER SER A . n 
A 1 348 VAL 348 348 348 VAL VAL A . n 
A 1 349 LEU 349 349 ?   ?   ?   A . n 
A 1 350 CYS 350 350 ?   ?   ?   A . n 
A 1 351 VAL 351 351 ?   ?   ?   A . n 
A 1 352 LEU 352 352 ?   ?   ?   A . n 
A 1 353 LYS 353 353 ?   ?   ?   A . n 
A 1 354 ASP 354 354 ?   ?   ?   A . n 
A 1 355 THR 355 355 ?   ?   ?   A . n 
A 1 356 THR 356 356 ?   ?   ?   A . n 
A 1 357 THR 357 357 ?   ?   ?   A . n 
A 1 358 GLN 358 358 ?   ?   ?   A . n 
A 1 359 LYS 359 359 ?   ?   ?   A . n 
A 1 360 HIS 360 360 ?   ?   ?   A . n 
A 1 361 ASN 361 361 ?   ?   ?   A . n 
A 1 362 ILE 362 362 ?   ?   ?   A . n 
A 1 363 ASP 363 363 ?   ?   ?   A . n 
A 1 364 THR 364 364 ?   ?   ?   A . n 
A 1 365 VAL 365 365 ?   ?   ?   A . n 
A 1 366 VAL 366 366 ?   ?   ?   A . n 
A 1 367 ASP 367 367 367 ASP ASP A . n 
A 1 368 PHE 368 368 368 PHE PHE A . n 
A 1 369 MET 369 369 369 MET MET A . n 
A 1 370 THR 370 370 370 THR THR A . n 
A 1 371 LEU 371 371 371 LEU LEU A . n 
A 1 372 LEU 372 372 372 LEU LEU A . n 
A 1 373 ALA 373 373 373 ALA ALA A . n 
A 1 374 GLY 374 374 374 GLY GLY A . n 
A 1 375 LEU 375 375 ?   ?   ?   A . n 
A 1 376 GLU 376 376 ?   ?   ?   A . n 
A 1 377 PRO 377 377 ?   ?   ?   A . n 
A 1 378 SER 378 378 ?   ?   ?   A . n 
A 1 379 LYS 379 379 ?   ?   ?   A . n 
A 1 380 PRO 380 380 ?   ?   ?   A . n 
A 1 381 LYS 381 381 ?   ?   ?   A . n 
A 1 382 HIS 382 382 ?   ?   ?   A . n 
A 1 383 LEU 383 383 ?   ?   ?   A . n 
A 1 384 THR 384 384 ?   ?   ?   A . n 
A 1 385 ASN 385 385 ?   ?   ?   A . n 
A 1 386 SER 386 386 ?   ?   ?   A . n 
A 1 387 ALA 387 387 ?   ?   ?   A . n 
A 1 388 CYS 388 388 ?   ?   ?   A . n 
A 1 389 ASP 389 389 ?   ?   ?   A . n 
A 1 390 GLU 390 390 ?   ?   ?   A . n 
A 1 391 HIS 391 391 ?   ?   ?   A . n 
A 1 392 PRO 392 392 ?   ?   ?   A . n 
A 1 393 GLY 393 393 ?   ?   ?   A . n 
A 1 394 SER 394 394 ?   ?   ?   A . n 
A 1 395 GLY 395 395 ?   ?   ?   A . n 
A 1 396 GLY 396 396 ?   ?   ?   A . n 
A 1 397 SER 397 397 ?   ?   ?   A . n 
A 1 398 GLY 398 398 ?   ?   ?   A . n 
A 1 399 HIS 399 399 ?   ?   ?   A . n 
A 1 400 HIS 400 400 ?   ?   ?   A . n 
A 1 401 HIS 401 401 ?   ?   ?   A . n 
A 1 402 HIS 402 402 ?   ?   ?   A . n 
A 1 403 HIS 403 403 ?   ?   ?   A . n 
A 1 404 HIS 404 404 ?   ?   ?   A . n 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A LYS 183 ? CG  ? A LYS 183 CG  
2  1 Y 1 A LYS 183 ? CD  ? A LYS 183 CD  
3  1 Y 1 A LYS 183 ? CE  ? A LYS 183 CE  
4  1 Y 1 A LYS 183 ? NZ  ? A LYS 183 NZ  
5  1 Y 1 A GLU 184 ? CG  ? A GLU 184 CG  
6  1 Y 1 A GLU 184 ? CD  ? A GLU 184 CD  
7  1 Y 1 A GLU 184 ? OE1 ? A GLU 184 OE1 
8  1 Y 1 A GLU 184 ? OE2 ? A GLU 184 OE2 
9  1 Y 1 A ARG 185 ? CG  ? A ARG 185 CG  
10 1 Y 1 A ARG 185 ? CD  ? A ARG 185 CD  
11 1 Y 1 A ARG 185 ? NE  ? A ARG 185 NE  
12 1 Y 1 A ARG 185 ? CZ  ? A ARG 185 CZ  
13 1 Y 1 A ARG 185 ? NH1 ? A ARG 185 NH1 
14 1 Y 1 A ARG 185 ? NH2 ? A ARG 185 NH2 
15 1 Y 1 A TYR 186 ? CG  ? A TYR 186 CG  
16 1 Y 1 A TYR 186 ? CD1 ? A TYR 186 CD1 
17 1 Y 1 A TYR 186 ? CD2 ? A TYR 186 CD2 
18 1 Y 1 A TYR 186 ? CE1 ? A TYR 186 CE1 
19 1 Y 1 A TYR 186 ? CE2 ? A TYR 186 CE2 
20 1 Y 1 A TYR 186 ? CZ  ? A TYR 186 CZ  
21 1 Y 1 A TYR 186 ? OH  ? A TYR 186 OH  
22 1 Y 1 A PHE 187 ? CG  ? A PHE 187 CG  
23 1 Y 1 A PHE 187 ? CD1 ? A PHE 187 CD1 
24 1 Y 1 A PHE 187 ? CD2 ? A PHE 187 CD2 
25 1 Y 1 A PHE 187 ? CE1 ? A PHE 187 CE1 
26 1 Y 1 A PHE 187 ? CE2 ? A PHE 187 CE2 
27 1 Y 1 A PHE 187 ? CZ  ? A PHE 187 CZ  
28 1 Y 1 A GLU 188 ? CG  ? A GLU 188 CG  
29 1 Y 1 A GLU 188 ? CD  ? A GLU 188 CD  
30 1 Y 1 A GLU 188 ? OE1 ? A GLU 188 OE1 
31 1 Y 1 A GLU 188 ? OE2 ? A GLU 188 OE2 
32 1 Y 1 A PHE 343 ? CG  ? A PHE 343 CG  
33 1 Y 1 A PHE 343 ? CD1 ? A PHE 343 CD1 
34 1 Y 1 A PHE 343 ? CD2 ? A PHE 343 CD2 
35 1 Y 1 A PHE 343 ? CE1 ? A PHE 343 CE1 
36 1 Y 1 A PHE 343 ? CE2 ? A PHE 343 CE2 
37 1 Y 1 A PHE 343 ? CZ  ? A PHE 343 CZ  
38 1 Y 1 A SER 344 ? OG  ? A SER 344 OG  
39 1 Y 1 A TRP 345 ? CG  ? A TRP 345 CG  
40 1 Y 1 A TRP 345 ? CD1 ? A TRP 345 CD1 
41 1 Y 1 A TRP 345 ? CD2 ? A TRP 345 CD2 
42 1 Y 1 A TRP 345 ? NE1 ? A TRP 345 NE1 
43 1 Y 1 A TRP 345 ? CE2 ? A TRP 345 CE2 
44 1 Y 1 A TRP 345 ? CE3 ? A TRP 345 CE3 
45 1 Y 1 A TRP 345 ? CZ2 ? A TRP 345 CZ2 
46 1 Y 1 A TRP 345 ? CZ3 ? A TRP 345 CZ3 
47 1 Y 1 A TRP 345 ? CH2 ? A TRP 345 CH2 
48 1 Y 1 A LEU 346 ? CG  ? A LEU 346 CG  
49 1 Y 1 A LEU 346 ? CD1 ? A LEU 346 CD1 
50 1 Y 1 A LEU 346 ? CD2 ? A LEU 346 CD2 
51 1 Y 1 A SER 347 ? OG  ? A SER 347 OG  
52 1 Y 1 A VAL 348 ? CG1 ? A VAL 348 CG1 
53 1 Y 1 A VAL 348 ? CG2 ? A VAL 348 CG2 
54 1 Y 1 A ASP 367 ? CG  ? A ASP 367 CG  
55 1 Y 1 A ASP 367 ? OD1 ? A ASP 367 OD1 
56 1 Y 1 A ASP 367 ? OD2 ? A ASP 367 OD2 
57 1 Y 1 A PHE 368 ? CG  ? A PHE 368 CG  
58 1 Y 1 A PHE 368 ? CD1 ? A PHE 368 CD1 
59 1 Y 1 A PHE 368 ? CD2 ? A PHE 368 CD2 
60 1 Y 1 A PHE 368 ? CE1 ? A PHE 368 CE1 
61 1 Y 1 A PHE 368 ? CE2 ? A PHE 368 CE2 
62 1 Y 1 A PHE 368 ? CZ  ? A PHE 368 CZ  
63 1 Y 1 A MET 369 ? CG  ? A MET 369 CG  
64 1 Y 1 A MET 369 ? SD  ? A MET 369 SD  
65 1 Y 1 A MET 369 ? CE  ? A MET 369 CE  
66 1 Y 1 A THR 370 ? OG1 ? A THR 370 OG1 
67 1 Y 1 A THR 370 ? CG2 ? A THR 370 CG2 
68 1 Y 1 A LEU 371 ? CG  ? A LEU 371 CG  
69 1 Y 1 A LEU 371 ? CD1 ? A LEU 371 CD1 
70 1 Y 1 A LEU 371 ? CD2 ? A LEU 371 CD2 
71 1 Y 1 A LEU 372 ? CG  ? A LEU 372 CG  
72 1 Y 1 A LEU 372 ? CD1 ? A LEU 372 CD1 
73 1 Y 1 A LEU 372 ? CD2 ? A LEU 372 CD2 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9KRG 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9KRG 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9KRG 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9KRG 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.90 
_refine.ls_d_res_low                             ? 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'REAL-SPACE (WEIGHTED MAP SUM AT ATOM CENTERS)' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_struct.entry_id                     9KRG 
_struct.title                        'Cryo-EM structure of human pannexin-3 heptamer' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9KRG 
_struct_keywords.text            'Pannexin, Innexin, TRANSPORT PROTEIN' 
_struct_keywords.pdbx_keywords   'TRANSPORT PROTEIN' 
# 
_struct_asym.id                            A 
_struct_asym.pdbx_blank_PDB_chainid_flag   N 
_struct_asym.pdbx_modified                 N 
_struct_asym.entity_id                     1 
_struct_asym.details                       ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    PANX3_HUMAN 
_struct_ref.pdbx_db_accession          Q96QZ0 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MSLAHTAAEYMLSDALLPDRRGPRLKGLRLELPLDRIVKFVAVGSPLLLMSLAFAQEFSSGSPISCFSPSNFSIRQAAYV
DSSCWDSLLHHKQDGPGQDKMKSLWPHKALPYSLLALALLMYLPVLLWQYAAVPALSSDLLFIISELDKSYNRSIRLVQH
MLKIRQKSSDPYVFWNELEKARKERYFEFPLLERYLACKQRSHSLVATYLLRNSLLLIFTSATYLYLGHFHLDVFFQEEF
SCSIKTGLLSDETHVPNLITCRLTSLSIFQIVSLSSVAIYTILVPVIIYNLTRLCRWDKRLLSVYEMLPAFDLLSRKMLG
CPINDLNVILLFLRANISELISFSWLSVLCVLKDTTTQKHNIDTVVDFMTLLAGLEPSKPKHLTNSACDEHP
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9KRG 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 392 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q96QZ0 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  392 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       392 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9KRG GLY A 393 ? UNP Q96QZ0 ? ? 'expression tag' 393 1  
1 9KRG SER A 394 ? UNP Q96QZ0 ? ? 'expression tag' 394 2  
1 9KRG GLY A 395 ? UNP Q96QZ0 ? ? 'expression tag' 395 3  
1 9KRG GLY A 396 ? UNP Q96QZ0 ? ? 'expression tag' 396 4  
1 9KRG SER A 397 ? UNP Q96QZ0 ? ? 'expression tag' 397 5  
1 9KRG GLY A 398 ? UNP Q96QZ0 ? ? 'expression tag' 398 6  
1 9KRG HIS A 399 ? UNP Q96QZ0 ? ? 'expression tag' 399 7  
1 9KRG HIS A 400 ? UNP Q96QZ0 ? ? 'expression tag' 400 8  
1 9KRG HIS A 401 ? UNP Q96QZ0 ? ? 'expression tag' 401 9  
1 9KRG HIS A 402 ? UNP Q96QZ0 ? ? 'expression tag' 402 10 
1 9KRG HIS A 403 ? UNP Q96QZ0 ? ? 'expression tag' 403 11 
1 9KRG HIS A 404 ? UNP Q96QZ0 ? ? 'expression tag' 404 12 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 'complete point assembly'                ? heptameric 7 
2 'point asymmetric unit'                  ? monomeric  1 
3 'point asymmetric unit, std point frame' ? monomeric  1 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 '(1-7)' A 
2 1       A 
3 P       A 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
P 'transform to point frame' ?     ?     0.76108196  -0.64865573 0.00000037  -14.16575 0.64865573  0.76108196  -0.00000034 
-177.62686 -0.00000006 0.00000050 1.00000000 -125.41959 
1 'identity operation'       1_555 x,y,z 1.00000000  0.00000000  0.00000000  0.00000   0.00000000  1.00000000  0.00000000  0.00000 
0.00000000  0.00000000 1.00000000 0.00000    
2 'point symmetry operation' ?     ?     0.62348980  -0.78183148 0.00000037  145.95097 0.78183148  0.62348980  0.00000024  
-51.07050  -0.00000041 0.00000014 1.00000000 0.00003    
3 'point symmetry operation' ?     ?     -0.22252093 -0.97492791 0.00000041  276.87843 0.97492791  -0.22252093 0.00000067  
31.19663   -0.00000056 0.00000055 1.00000000 0.00000    
4 'point symmetry operation' ?     ?     -0.90096887 -0.43388374 0.00000010  294.19134 0.43388374  -0.90096887 0.00000097  
184.85255  -0.00000033 0.00000092 1.00000000 -0.00007   
5 'point symmetry operation' ?     ?     -0.90096887 0.43388374  -0.00000033 184.85272 -0.43388374 -0.90096887 0.00000092  
294.19123  0.00000010  0.00000098 1.00000000 -0.00014   
6 'point symmetry operation' ?     ?     -0.22252093 0.97492791  -0.00000056 31.19679  -0.97492791 -0.22252093 0.00000055  
276.87841  0.00000041  0.00000067 1.00000000 -0.00014   
7 'point symmetry operation' ?     ?     0.62348980  0.78183148  -0.00000041 -51.07041 -0.78183148 0.62348980  0.00000014  
145.95100  0.00000037  0.00000024 1.00000000 -0.00008   
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 LEU A 32  ? GLY A 61  ? LEU A 32  GLY A 61  1 ? 30 
HELX_P HELX_P2  AA2 ILE A 74  ? LEU A 88  ? ILE A 74  LEU A 88  1 ? 15 
HELX_P HELX_P3  AA3 LEU A 104 ? ALA A 109 ? LEU A 104 ALA A 109 1 ? 6  
HELX_P HELX_P4  AA4 ALA A 109 ? ALA A 132 ? ALA A 109 ALA A 132 1 ? 24 
HELX_P HELX_P5  AA5 ALA A 132 ? GLN A 159 ? ALA A 132 GLN A 159 1 ? 28 
HELX_P HELX_P6  AA6 PRO A 190 ? ARG A 201 ? PRO A 190 ARG A 201 1 ? 12 
HELX_P HELX_P7  AA7 LEU A 205 ? HIS A 231 ? LEU A 205 HIS A 231 1 ? 27 
HELX_P HELX_P8  AA8 LEU A 232 ? PHE A 235 ? LEU A 232 PHE A 235 5 ? 4  
HELX_P HELX_P9  AA9 SER A 265 ? LEU A 294 ? SER A 265 LEU A 294 1 ? 30 
HELX_P HELX_P10 AB1 ALA A 310 ? LYS A 317 ? ALA A 310 LYS A 317 1 ? 8  
HELX_P HELX_P11 AB2 ASP A 325 ? ASN A 336 ? ASP A 325 ASN A 336 1 ? 12 
HELX_P HELX_P12 AB3 PHE A 368 ? GLY A 374 ? PHE A 368 GLY A 374 1 ? 7  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 66 SG ? ? ? 1_555 A CYS 261 SG ? ? A CYS 66 A CYS 261 1_555 ? ? ? ? ? ? ? 2.030 ? ? 
disulf2 disulf ? ? A CYS 84 SG ? ? ? 1_555 A CYS 242 SG ? ? A CYS 84 A CYS 242 1_555 ? ? ? ? ? ? ? 2.033 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 66 ? CYS A 261 ? CYS A 66 ? 1_555 CYS A 261 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 84 ? CYS A 242 ? CYS A 84 ? 1_555 CYS A 242 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   3 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ILE A 64  ? CYS A 66  ? ILE A 64  CYS A 66  
AA1 2 ILE A 259 ? LEU A 263 ? ILE A 259 LEU A 263 
AA1 3 GLU A 239 ? CYS A 242 ? GLU A 239 CYS A 242 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N SER A 65  ? N SER A 65  O ARG A 262 ? O ARG A 262 
AA1 2 3 O ILE A 259 ? O ILE A 259 N CYS A 242 ? N CYS A 242 
# 
_pdbx_entry_details.entry_id                   9KRG 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 71  ? ? -98.28  36.84   
2 1 SER A 73  ? ? 58.27   -137.31 
3 1 ALA A 109 ? ? -98.42  32.20   
4 1 GLU A 184 ? ? -91.08  54.91   
5 1 HIS A 203 ? ? -140.82 33.97   
6 1 LEU A 319 ? ? -172.59 -178.19 
# 
_pdbx_point_symmetry.entry_id             9KRG 
_pdbx_point_symmetry.Schoenflies_symbol   C 
_pdbx_point_symmetry.circular_symmetry    7 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9KRG 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      'RIGID BODY FIT' 
# 
_em_3d_fitting_list.id                            1 
_em_3d_fitting_list.3d_fitting_id                 1 
_em_3d_fitting_list.pdb_entry_id                  9KOM 
_em_3d_fitting_list.pdb_chain_id                  ? 
_em_3d_fitting_list.pdb_chain_residue_range       ? 
_em_3d_fitting_list.details                       ? 
_em_3d_fitting_list.chain_id                      ? 
_em_3d_fitting_list.chain_residue_range           ? 
_em_3d_fitting_list.source_name                   PDB 
_em_3d_fitting_list.type                          'experimental model' 
_em_3d_fitting_list.accession_code                9KOM 
_em_3d_fitting_list.initial_refinement_model_id   1 
# 
_em_3d_reconstruction.entry_id                    9KRG 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   'FOURIER SPACE' 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  2.9 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               303431 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            8 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Pannexin-3 heptamer' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        9KRG 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      2.7 
_em_imaging.nominal_defocus_min             1000 
_em_imaging.nominal_defocus_max             2200 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              9KRG 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   277 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9KRG 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
_em_single_particle_entity.entry_id              9KRG 
_em_single_particle_entity.id                    1 
_em_single_particle_entity.image_processing_id   1 
_em_single_particle_entity.point_symmetry        C7 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET 1   ? A MET 1   
2   1 Y 1 A SER 2   ? A SER 2   
3   1 Y 1 A LEU 3   ? A LEU 3   
4   1 Y 1 A ALA 4   ? A ALA 4   
5   1 Y 1 A HIS 5   ? A HIS 5   
6   1 Y 1 A THR 6   ? A THR 6   
7   1 Y 1 A ALA 7   ? A ALA 7   
8   1 Y 1 A ALA 8   ? A ALA 8   
9   1 Y 1 A GLU 9   ? A GLU 9   
10  1 Y 1 A TYR 10  ? A TYR 10  
11  1 Y 1 A MET 11  ? A MET 11  
12  1 Y 1 A LEU 12  ? A LEU 12  
13  1 Y 1 A SER 13  ? A SER 13  
14  1 Y 1 A ASP 14  ? A ASP 14  
15  1 Y 1 A ALA 15  ? A ALA 15  
16  1 Y 1 A LEU 16  ? A LEU 16  
17  1 Y 1 A LEU 17  ? A LEU 17  
18  1 Y 1 A PRO 18  ? A PRO 18  
19  1 Y 1 A ASP 19  ? A ASP 19  
20  1 Y 1 A ARG 20  ? A ARG 20  
21  1 Y 1 A ARG 21  ? A ARG 21  
22  1 Y 1 A GLY 22  ? A GLY 22  
23  1 Y 1 A PRO 23  ? A PRO 23  
24  1 Y 1 A ARG 24  ? A ARG 24  
25  1 Y 1 A LEU 25  ? A LEU 25  
26  1 Y 1 A LYS 26  ? A LYS 26  
27  1 Y 1 A GLN 93  ? A GLN 93  
28  1 Y 1 A ASP 94  ? A ASP 94  
29  1 Y 1 A GLY 95  ? A GLY 95  
30  1 Y 1 A PRO 96  ? A PRO 96  
31  1 Y 1 A GLY 97  ? A GLY 97  
32  1 Y 1 A GLN 98  ? A GLN 98  
33  1 Y 1 A ASP 99  ? A ASP 99  
34  1 Y 1 A LYS 100 ? A LYS 100 
35  1 Y 1 A MET 101 ? A MET 101 
36  1 Y 1 A MET 161 ? A MET 161 
37  1 Y 1 A LEU 162 ? A LEU 162 
38  1 Y 1 A LYS 163 ? A LYS 163 
39  1 Y 1 A ILE 164 ? A ILE 164 
40  1 Y 1 A ARG 165 ? A ARG 165 
41  1 Y 1 A GLN 166 ? A GLN 166 
42  1 Y 1 A LYS 167 ? A LYS 167 
43  1 Y 1 A SER 168 ? A SER 168 
44  1 Y 1 A SER 169 ? A SER 169 
45  1 Y 1 A ASP 170 ? A ASP 170 
46  1 Y 1 A PRO 171 ? A PRO 171 
47  1 Y 1 A TYR 172 ? A TYR 172 
48  1 Y 1 A VAL 173 ? A VAL 173 
49  1 Y 1 A PHE 174 ? A PHE 174 
50  1 Y 1 A TRP 175 ? A TRP 175 
51  1 Y 1 A ASN 176 ? A ASN 176 
52  1 Y 1 A GLU 177 ? A GLU 177 
53  1 Y 1 A LEU 178 ? A LEU 178 
54  1 Y 1 A GLU 179 ? A GLU 179 
55  1 Y 1 A LYS 180 ? A LYS 180 
56  1 Y 1 A ALA 181 ? A ALA 181 
57  1 Y 1 A ARG 182 ? A ARG 182 
58  1 Y 1 A LEU 301 ? A LEU 301 
59  1 Y 1 A LEU 302 ? A LEU 302 
60  1 Y 1 A SER 303 ? A SER 303 
61  1 Y 1 A VAL 304 ? A VAL 304 
62  1 Y 1 A TYR 305 ? A TYR 305 
63  1 Y 1 A GLU 306 ? A GLU 306 
64  1 Y 1 A MET 307 ? A MET 307 
65  1 Y 1 A LEU 308 ? A LEU 308 
66  1 Y 1 A LEU 349 ? A LEU 349 
67  1 Y 1 A CYS 350 ? A CYS 350 
68  1 Y 1 A VAL 351 ? A VAL 351 
69  1 Y 1 A LEU 352 ? A LEU 352 
70  1 Y 1 A LYS 353 ? A LYS 353 
71  1 Y 1 A ASP 354 ? A ASP 354 
72  1 Y 1 A THR 355 ? A THR 355 
73  1 Y 1 A THR 356 ? A THR 356 
74  1 Y 1 A THR 357 ? A THR 357 
75  1 Y 1 A GLN 358 ? A GLN 358 
76  1 Y 1 A LYS 359 ? A LYS 359 
77  1 Y 1 A HIS 360 ? A HIS 360 
78  1 Y 1 A ASN 361 ? A ASN 361 
79  1 Y 1 A ILE 362 ? A ILE 362 
80  1 Y 1 A ASP 363 ? A ASP 363 
81  1 Y 1 A THR 364 ? A THR 364 
82  1 Y 1 A VAL 365 ? A VAL 365 
83  1 Y 1 A VAL 366 ? A VAL 366 
84  1 Y 1 A LEU 375 ? A LEU 375 
85  1 Y 1 A GLU 376 ? A GLU 376 
86  1 Y 1 A PRO 377 ? A PRO 377 
87  1 Y 1 A SER 378 ? A SER 378 
88  1 Y 1 A LYS 379 ? A LYS 379 
89  1 Y 1 A PRO 380 ? A PRO 380 
90  1 Y 1 A LYS 381 ? A LYS 381 
91  1 Y 1 A HIS 382 ? A HIS 382 
92  1 Y 1 A LEU 383 ? A LEU 383 
93  1 Y 1 A THR 384 ? A THR 384 
94  1 Y 1 A ASN 385 ? A ASN 385 
95  1 Y 1 A SER 386 ? A SER 386 
96  1 Y 1 A ALA 387 ? A ALA 387 
97  1 Y 1 A CYS 388 ? A CYS 388 
98  1 Y 1 A ASP 389 ? A ASP 389 
99  1 Y 1 A GLU 390 ? A GLU 390 
100 1 Y 1 A HIS 391 ? A HIS 391 
101 1 Y 1 A PRO 392 ? A PRO 392 
102 1 Y 1 A GLY 393 ? A GLY 393 
103 1 Y 1 A SER 394 ? A SER 394 
104 1 Y 1 A GLY 395 ? A GLY 395 
105 1 Y 1 A GLY 396 ? A GLY 396 
106 1 Y 1 A SER 397 ? A SER 397 
107 1 Y 1 A GLY 398 ? A GLY 398 
108 1 Y 1 A HIS 399 ? A HIS 399 
109 1 Y 1 A HIS 400 ? A HIS 400 
110 1 Y 1 A HIS 401 ? A HIS 401 
111 1 Y 1 A HIS 402 ? A HIS 402 
112 1 Y 1 A HIS 403 ? A HIS 403 
113 1 Y 1 A HIS 404 ? A HIS 404 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-11-27 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           9KRG 
_em_admin.last_update        2025-01-15 
_em_admin.map_release_date   2025-01-15 
_em_admin.title              'Cryo-EM structure of human pannexin-3 heptamer' 
# 
loop_
_em_buffer_component.buffer_id 
_em_buffer_component.concentration 
_em_buffer_component.concentration_units 
_em_buffer_component.formula 
_em_buffer_component.id 
_em_buffer_component.name 
1 150 mM NaCl     1 'Sodium chloride' 
1 50  mM C4H11NO3 2 Tris              
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   1 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    1 
_em_image_recording.num_real_images                     ? 
# 
_em_particle_selection.details                  ? 
_em_particle_selection.id                       1 
_em_particle_selection.image_processing_id      1 
_em_particle_selection.method                   ? 
_em_particle_selection.num_particles_selected   3297870 
_em_particle_selection.reference_model          ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? cryoSPARC 4.0    
'IMAGE ACQUISITION'             ? 2  ? ? 1 SerialEM  ?      
MASKING                         ? 3  ? ? ? ?         ?      
'CTF CORRECTION'                ? 4  1 ? ? CTFFIND   4.1.8  
'CTF CORRECTION'                ? 5  1 ? ? cryoSPARC 4.0    
'LAYERLINE INDEXING'            ? 6  ? ? ? ?         ?      
'DIFFRACTION INDEXING'          ? 7  ? ? ? ?         ?      
'MODEL FITTING'                 ? 8  ? 1 ? PHENIX    1.20.1 
OTHER                           ? 9  ? ? ? ?         ?      
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? cryoSPARC 4.0    
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? cryoSPARC 4.0    
CLASSIFICATION                  ? 12 1 ? ? ?         ?      
RECONSTRUCTION                  ? 13 1 ? ? cryoSPARC 4.0    
'VOLUME SELECTION'              ? 14 1 1 1 ?         ?      
'SERIES ALIGNMENT'              ? 15 1 1 1 ?         ?      
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ?         ?      
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ?         ?      
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ?         ?      
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ?         ?      
'MODEL REFINEMENT'              ? 20 ? 1 ? PHENIX    1.20.1 
# 
_em_specimen.concentration           2 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Japan Society for the Promotion of Science (JSPS)'                      Japan 23H02453 1 
'Japan Society for the Promotion of Science (JSPS)'                      Japan 20J01396 2 
'Japan Society for the Promotion of Science (JSPS)'                      Japan 20K06514 3 
'Ministry of Education, Culture, Sports, Science and Technology (Japan)' Japan ?        4 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   9KOM 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9KRG 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . GLY A 1 27  ? 140.928 113.672 148.076 1.00 171.99 ? 27  GLY A N   1 
ATOM 2    C CA  . GLY A 1 27  ? 141.781 114.452 147.198 1.00 172.12 ? 27  GLY A CA  1 
ATOM 3    C C   . GLY A 1 27  ? 143.116 113.789 146.921 1.00 173.02 ? 27  GLY A C   1 
ATOM 4    O O   . GLY A 1 27  ? 144.104 114.461 146.633 1.00 173.31 ? 27  GLY A O   1 
ATOM 5    N N   . LEU A 1 28  ? 143.141 112.463 147.012 1.00 156.85 ? 28  LEU A N   1 
ATOM 6    C CA  . LEU A 1 28  ? 144.363 111.717 146.760 1.00 153.71 ? 28  LEU A CA  1 
ATOM 7    C C   . LEU A 1 28  ? 144.720 111.751 145.279 1.00 157.94 ? 28  LEU A C   1 
ATOM 8    O O   . LEU A 1 28  ? 143.851 111.844 144.408 1.00 161.17 ? 28  LEU A O   1 
ATOM 9    C CB  . LEU A 1 28  ? 144.204 110.268 147.222 1.00 152.03 ? 28  LEU A CB  1 
ATOM 10   C CG  . LEU A 1 28  ? 145.471 109.553 147.692 1.00 154.31 ? 28  LEU A CG  1 
ATOM 11   C CD1 . LEU A 1 28  ? 146.245 110.423 148.667 1.00 155.57 ? 28  LEU A CD1 1 
ATOM 12   C CD2 . LEU A 1 28  ? 145.127 108.214 148.323 1.00 153.28 ? 28  LEU A CD2 1 
ATOM 13   N N   . ARG A 1 29  ? 146.017 111.676 144.998 1.00 168.33 ? 29  ARG A N   1 
ATOM 14   C CA  . ARG A 1 29  ? 146.529 111.617 143.634 1.00 167.24 ? 29  ARG A CA  1 
ATOM 15   C C   . ARG A 1 29  ? 146.962 110.187 143.350 1.00 166.78 ? 29  ARG A C   1 
ATOM 16   O O   . ARG A 1 29  ? 147.849 109.657 144.027 1.00 167.68 ? 29  ARG A O   1 
ATOM 17   C CB  . ARG A 1 29  ? 147.689 112.589 143.434 1.00 168.55 ? 29  ARG A CB  1 
ATOM 18   C CG  . ARG A 1 29  ? 148.440 112.381 142.132 1.00 170.45 ? 29  ARG A CG  1 
ATOM 19   C CD  . ARG A 1 29  ? 149.831 112.987 142.193 1.00 170.88 ? 29  ARG A CD  1 
ATOM 20   N NE  . ARG A 1 29  ? 149.847 114.244 142.931 1.00 171.22 ? 29  ARG A NE  1 
ATOM 21   C CZ  . ARG A 1 29  ? 149.493 115.416 142.422 1.00 171.20 ? 29  ARG A CZ  1 
ATOM 22   N NH1 . ARG A 1 29  ? 149.095 115.530 141.165 1.00 168.99 ? 29  ARG A NH1 1 
ATOM 23   N NH2 . ARG A 1 29  ? 149.542 116.499 143.191 1.00 172.58 ? 29  ARG A NH2 1 
ATOM 24   N N   . LEU A 1 30  ? 146.343 109.572 142.343 1.00 163.92 ? 30  LEU A N   1 
ATOM 25   C CA  . LEU A 1 30  ? 146.477 108.141 142.109 1.00 163.45 ? 30  LEU A CA  1 
ATOM 26   C C   . LEU A 1 30  ? 147.231 107.817 140.825 1.00 164.98 ? 30  LEU A C   1 
ATOM 27   O O   . LEU A 1 30  ? 147.225 106.659 140.393 1.00 166.97 ? 30  LEU A O   1 
ATOM 28   C CB  . LEU A 1 30  ? 145.091 107.496 142.075 1.00 165.45 ? 30  LEU A CB  1 
ATOM 29   C CG  . LEU A 1 30  ? 144.441 107.277 143.442 1.00 164.18 ? 30  LEU A CG  1 
ATOM 30   C CD1 . LEU A 1 30  ? 142.925 107.285 143.320 1.00 168.24 ? 30  LEU A CD1 1 
ATOM 31   C CD2 . LEU A 1 30  ? 144.922 105.991 144.081 1.00 159.83 ? 30  LEU A CD2 1 
ATOM 32   N N   . GLU A 1 31  ? 147.874 108.801 140.202 1.00 177.94 ? 31  GLU A N   1 
ATOM 33   C CA  . GLU A 1 31  ? 148.600 108.599 138.954 1.00 177.15 ? 31  GLU A CA  1 
ATOM 34   C C   . GLU A 1 31  ? 149.856 109.451 138.972 1.00 175.47 ? 31  GLU A C   1 
ATOM 35   O O   . GLU A 1 31  ? 149.813 110.614 139.387 1.00 178.24 ? 31  GLU A O   1 
ATOM 36   C CB  . GLU A 1 31  ? 147.727 108.955 137.749 1.00 179.12 ? 31  GLU A CB  1 
ATOM 37   C CG  . GLU A 1 31  ? 148.052 108.166 136.495 1.00 185.26 ? 31  GLU A CG  1 
ATOM 38   C CD  . GLU A 1 31  ? 146.886 108.105 135.530 1.00 188.13 ? 31  GLU A CD  1 
ATOM 39   O OE1 . GLU A 1 31  ? 146.072 109.051 135.520 1.00 188.49 ? 31  GLU A OE1 1 
ATOM 40   O OE2 . GLU A 1 31  ? 146.784 107.110 134.780 1.00 186.64 ? 31  GLU A OE2 1 
ATOM 41   N N   . LEU A 1 32  ? 150.971 108.877 138.528 1.00 132.44 ? 32  LEU A N   1 
ATOM 42   C CA  . LEU A 1 32  ? 152.228 109.607 138.454 1.00 134.48 ? 32  LEU A CA  1 
ATOM 43   C C   . LEU A 1 32  ? 152.112 110.723 137.426 1.00 143.61 ? 32  LEU A C   1 
ATOM 44   O O   . LEU A 1 32  ? 151.406 110.568 136.422 1.00 152.90 ? 32  LEU A O   1 
ATOM 45   C CB  . LEU A 1 32  ? 153.380 108.669 138.102 1.00 136.83 ? 32  LEU A CB  1 
ATOM 46   C CG  . LEU A 1 32  ? 154.147 108.081 139.287 1.00 138.30 ? 32  LEU A CG  1 
ATOM 47   C CD1 . LEU A 1 32  ? 153.331 107.001 139.973 1.00 138.53 ? 32  LEU A CD1 1 
ATOM 48   C CD2 . LEU A 1 32  ? 155.491 107.538 138.836 1.00 144.28 ? 32  LEU A CD2 1 
ATOM 49   N N   . PRO A 1 33  ? 152.763 111.869 137.652 1.00 137.05 ? 33  PRO A N   1 
ATOM 50   C CA  . PRO A 1 33  ? 152.632 112.987 136.700 1.00 141.15 ? 33  PRO A CA  1 
ATOM 51   C C   . PRO A 1 33  ? 153.103 112.660 135.296 1.00 142.42 ? 33  PRO A C   1 
ATOM 52   O O   . PRO A 1 33  ? 152.510 113.140 134.322 1.00 143.26 ? 33  PRO A O   1 
ATOM 53   C CB  . PRO A 1 33  ? 153.491 114.080 137.348 1.00 139.48 ? 33  PRO A CB  1 
ATOM 54   C CG  . PRO A 1 33  ? 153.455 113.755 138.802 1.00 135.84 ? 33  PRO A CG  1 
ATOM 55   C CD  . PRO A 1 33  ? 153.534 112.257 138.844 1.00 135.02 ? 33  PRO A CD  1 
ATOM 56   N N   . LEU A 1 34  ? 154.162 111.859 135.161 1.00 130.66 ? 34  LEU A N   1 
ATOM 57   C CA  . LEU A 1 34  ? 154.678 111.529 133.836 1.00 129.25 ? 34  LEU A CA  1 
ATOM 58   C C   . LEU A 1 34  ? 153.681 110.696 133.042 1.00 133.68 ? 34  LEU A C   1 
ATOM 59   O O   . LEU A 1 34  ? 153.469 110.936 131.845 1.00 137.41 ? 34  LEU A O   1 
ATOM 60   C CB  . LEU A 1 34  ? 156.010 110.794 133.970 1.00 127.74 ? 34  LEU A CB  1 
ATOM 61   C CG  . LEU A 1 34  ? 157.109 111.198 132.993 1.00 133.00 ? 34  LEU A CG  1 
ATOM 62   C CD1 . LEU A 1 34  ? 157.256 112.707 132.963 1.00 132.84 ? 34  LEU A CD1 1 
ATOM 63   C CD2 . LEU A 1 34  ? 158.419 110.541 133.379 1.00 138.21 ? 34  LEU A CD2 1 
ATOM 64   N N   . ASP A 1 35  ? 153.060 109.710 133.695 1.00 141.60 ? 35  ASP A N   1 
ATOM 65   C CA  . ASP A 1 35  ? 152.090 108.861 133.013 1.00 142.54 ? 35  ASP A CA  1 
ATOM 66   C C   . ASP A 1 35  ? 150.881 109.654 132.548 1.00 142.49 ? 35  ASP A C   1 
ATOM 67   O O   . ASP A 1 35  ? 150.290 109.329 131.514 1.00 148.74 ? 35  ASP A O   1 
ATOM 68   C CB  . ASP A 1 35  ? 151.652 107.721 133.933 1.00 146.97 ? 35  ASP A CB  1 
ATOM 69   C CG  . ASP A 1 35  ? 152.567 106.520 133.843 1.00 152.35 ? 35  ASP A CG  1 
ATOM 70   O OD1 . ASP A 1 35  ? 153.763 106.706 133.540 1.00 155.21 ? 35  ASP A OD1 1 
ATOM 71   O OD2 . ASP A 1 35  ? 152.091 105.389 134.076 1.00 150.51 ? 35  ASP A OD2 1 
ATOM 72   N N   . ARG A 1 36  ? 150.502 110.695 133.292 1.00 145.06 ? 36  ARG A N   1 
ATOM 73   C CA  . ARG A 1 36  ? 149.383 111.536 132.883 1.00 146.89 ? 36  ARG A CA  1 
ATOM 74   C C   . ARG A 1 36  ? 149.656 112.194 131.537 1.00 151.26 ? 36  ARG A C   1 
ATOM 75   O O   . ARG A 1 36  ? 148.836 112.112 130.612 1.00 161.10 ? 36  ARG A O   1 
ATOM 76   C CB  . ARG A 1 36  ? 149.113 112.592 133.952 1.00 148.62 ? 36  ARG A CB  1 
ATOM 77   C CG  . ARG A 1 36  ? 147.760 113.264 133.836 1.00 149.33 ? 36  ARG A CG  1 
ATOM 78   C CD  . ARG A 1 36  ? 147.388 113.964 135.131 1.00 151.22 ? 36  ARG A CD  1 
ATOM 79   N NE  . ARG A 1 36  ? 146.631 115.186 134.889 1.00 152.72 ? 36  ARG A NE  1 
ATOM 80   C CZ  . ARG A 1 36  ? 145.328 115.225 134.652 1.00 155.98 ? 36  ARG A CZ  1 
ATOM 81   N NH1 . ARG A 1 36  ? 144.598 114.122 134.620 1.00 153.04 ? 36  ARG A NH1 1 
ATOM 82   N NH2 . ARG A 1 36  ? 144.742 116.400 134.441 1.00 155.12 ? 36  ARG A NH2 1 
ATOM 83   N N   . ILE A 1 37  ? 150.819 112.835 131.399 1.00 127.75 ? 37  ILE A N   1 
ATOM 84   C CA  . ILE A 1 37  ? 151.133 113.501 130.141 1.00 131.37 ? 37  ILE A CA  1 
ATOM 85   C C   . ILE A 1 37  ? 151.371 112.481 129.034 1.00 133.98 ? 37  ILE A C   1 
ATOM 86   O O   . ILE A 1 37  ? 151.050 112.743 127.867 1.00 141.54 ? 37  ILE A O   1 
ATOM 87   C CB  . ILE A 1 37  ? 152.323 114.468 130.320 1.00 130.92 ? 37  ILE A CB  1 
ATOM 88   C CG1 . ILE A 1 37  ? 152.211 115.630 129.333 1.00 133.48 ? 37  ILE A CG1 1 
ATOM 89   C CG2 . ILE A 1 37  ? 153.662 113.767 130.165 1.00 130.56 ? 37  ILE A CG2 1 
ATOM 90   C CD1 . ILE A 1 37  ? 150.893 116.371 129.406 1.00 132.23 ? 37  ILE A CD1 1 
ATOM 91   N N   . VAL A 1 38  ? 151.891 111.296 129.371 1.00 114.54 ? 38  VAL A N   1 
ATOM 92   C CA  . VAL A 1 38  ? 152.103 110.271 128.352 1.00 109.00 ? 38  VAL A CA  1 
ATOM 93   C C   . VAL A 1 38  ? 150.768 109.807 127.782 1.00 111.69 ? 38  VAL A C   1 
ATOM 94   O O   . VAL A 1 38  ? 150.587 109.725 126.561 1.00 119.87 ? 38  VAL A O   1 
ATOM 95   C CB  . VAL A 1 38  ? 152.913 109.097 128.929 1.00 114.18 ? 38  VAL A CB  1 
ATOM 96   C CG1 . VAL A 1 38  ? 152.596 107.808 128.191 1.00 113.32 ? 38  VAL A CG1 1 
ATOM 97   C CG2 . VAL A 1 38  ? 154.392 109.399 128.849 1.00 120.15 ? 38  VAL A CG2 1 
ATOM 98   N N   . LYS A 1 39  ? 149.808 109.517 128.664 1.00 120.06 ? 39  LYS A N   1 
ATOM 99   C CA  . LYS A 1 39  ? 148.488 109.098 128.210 1.00 118.93 ? 39  LYS A CA  1 
ATOM 100  C C   . LYS A 1 39  ? 147.803 110.210 127.429 1.00 118.77 ? 39  LYS A C   1 
ATOM 101  O O   . LYS A 1 39  ? 147.177 109.953 126.392 1.00 127.17 ? 39  LYS A O   1 
ATOM 102  C CB  . LYS A 1 39  ? 147.639 108.660 129.406 1.00 120.82 ? 39  LYS A CB  1 
ATOM 103  C CG  . LYS A 1 39  ? 146.257 109.290 129.489 1.00 120.24 ? 39  LYS A CG  1 
ATOM 104  C CD  . LYS A 1 39  ? 145.682 109.169 130.889 1.00 129.03 ? 39  LYS A CD  1 
ATOM 105  C CE  . LYS A 1 39  ? 144.295 109.778 130.969 1.00 132.90 ? 39  LYS A CE  1 
ATOM 106  N NZ  . LYS A 1 39  ? 143.756 109.742 132.356 1.00 134.78 ? 39  LYS A NZ  1 
ATOM 107  N N   . PHE A 1 40  ? 147.940 111.457 127.892 1.00 134.16 ? 40  PHE A N   1 
ATOM 108  C CA  . PHE A 1 40  ? 147.302 112.575 127.205 1.00 136.06 ? 40  PHE A CA  1 
ATOM 109  C C   . PHE A 1 40  ? 147.838 112.723 125.789 1.00 138.23 ? 40  PHE A C   1 
ATOM 110  O O   . PHE A 1 40  ? 147.064 112.847 124.836 1.00 145.60 ? 40  PHE A O   1 
ATOM 111  C CB  . PHE A 1 40  ? 147.510 113.865 127.995 1.00 137.99 ? 40  PHE A CB  1 
ATOM 112  C CG  . PHE A 1 40  ? 146.352 114.225 128.874 1.00 138.64 ? 40  PHE A CG  1 
ATOM 113  C CD1 . PHE A 1 40  ? 145.084 114.368 128.342 1.00 143.31 ? 40  PHE A CD1 1 
ATOM 114  C CD2 . PHE A 1 40  ? 146.531 114.421 130.232 1.00 144.59 ? 40  PHE A CD2 1 
ATOM 115  C CE1 . PHE A 1 40  ? 144.014 114.697 129.148 1.00 147.92 ? 40  PHE A CE1 1 
ATOM 116  C CE2 . PHE A 1 40  ? 145.465 114.751 131.042 1.00 148.42 ? 40  PHE A CE2 1 
ATOM 117  C CZ  . PHE A 1 40  ? 144.205 114.891 130.499 1.00 148.93 ? 40  PHE A CZ  1 
ATOM 118  N N   . VAL A 1 41  ? 149.161 112.679 125.631 1.00 115.97 ? 41  VAL A N   1 
ATOM 119  C CA  . VAL A 1 41  ? 149.753 112.816 124.303 1.00 113.17 ? 41  VAL A CA  1 
ATOM 120  C C   . VAL A 1 41  ? 149.352 111.644 123.417 1.00 117.09 ? 41  VAL A C   1 
ATOM 121  O O   . VAL A 1 41  ? 148.874 111.829 122.287 1.00 116.07 ? 41  VAL A O   1 
ATOM 122  C CB  . VAL A 1 41  ? 151.282 112.947 124.415 1.00 112.16 ? 41  VAL A CB  1 
ATOM 123  C CG1 . VAL A 1 41  ? 151.954 112.510 123.134 1.00 110.77 ? 41  VAL A CG1 1 
ATOM 124  C CG2 . VAL A 1 41  ? 151.664 114.373 124.756 1.00 121.35 ? 41  VAL A CG2 1 
ATOM 125  N N   . ALA A 1 42  ? 149.504 110.418 123.932 1.00 120.11 ? 42  ALA A N   1 
ATOM 126  C CA  . ALA A 1 42  ? 149.288 109.228 123.118 1.00 112.23 ? 42  ALA A CA  1 
ATOM 127  C C   . ALA A 1 42  ? 147.840 109.085 122.681 1.00 110.42 ? 42  ALA A C   1 
ATOM 128  O O   . ALA A 1 42  ? 147.574 108.533 121.609 1.00 115.65 ? 42  ALA A O   1 
ATOM 129  C CB  . ALA A 1 42  ? 149.733 107.982 123.881 1.00 114.46 ? 42  ALA A CB  1 
ATOM 130  N N   . VAL A 1 43  ? 146.892 109.563 123.481 1.00 117.34 ? 43  VAL A N   1 
ATOM 131  C CA  . VAL A 1 43  ? 145.496 109.501 123.068 1.00 113.04 ? 43  VAL A CA  1 
ATOM 132  C C   . VAL A 1 43  ? 145.120 110.694 122.197 1.00 120.70 ? 43  VAL A C   1 
ATOM 133  O O   . VAL A 1 43  ? 144.438 110.535 121.183 1.00 130.90 ? 43  VAL A O   1 
ATOM 134  C CB  . VAL A 1 43  ? 144.587 109.384 124.309 1.00 120.53 ? 43  VAL A CB  1 
ATOM 135  C CG1 . VAL A 1 43  ? 143.215 109.982 124.044 1.00 120.25 ? 43  VAL A CG1 1 
ATOM 136  C CG2 . VAL A 1 43  ? 144.461 107.932 124.727 1.00 120.25 ? 43  VAL A CG2 1 
ATOM 137  N N   . GLY A 1 44  ? 145.567 111.900 122.557 1.00 134.79 ? 44  GLY A N   1 
ATOM 138  C CA  . GLY A 1 44  ? 145.136 113.084 121.835 1.00 138.07 ? 44  GLY A CA  1 
ATOM 139  C C   . GLY A 1 44  ? 145.683 113.180 120.425 1.00 135.07 ? 44  GLY A C   1 
ATOM 140  O O   . GLY A 1 44  ? 144.962 113.577 119.506 1.00 139.05 ? 44  GLY A O   1 
ATOM 141  N N   . SER A 1 45  ? 146.960 112.838 120.230 1.00 113.54 ? 45  SER A N   1 
ATOM 142  C CA  . SER A 1 45  ? 147.583 113.101 118.935 1.00 117.32 ? 45  SER A CA  1 
ATOM 143  C C   . SER A 1 45  ? 146.939 112.369 117.755 1.00 117.13 ? 45  SER A C   1 
ATOM 144  O O   . SER A 1 45  ? 146.758 113.014 116.705 1.00 122.99 ? 45  SER A O   1 
ATOM 145  C CB  . SER A 1 45  ? 149.089 112.818 119.010 1.00 121.85 ? 45  SER A CB  1 
ATOM 146  O OG  . SER A 1 45  ? 149.420 111.477 118.708 1.00 124.29 ? 45  SER A OG  1 
ATOM 147  N N   . PRO A 1 46  ? 146.587 111.073 117.824 1.00 116.63 ? 46  PRO A N   1 
ATOM 148  C CA  . PRO A 1 46  ? 145.895 110.481 116.668 1.00 120.07 ? 46  PRO A CA  1 
ATOM 149  C C   . PRO A 1 46  ? 144.552 111.127 116.385 1.00 126.22 ? 46  PRO A C   1 
ATOM 150  O O   . PRO A 1 46  ? 144.167 111.250 115.217 1.00 137.00 ? 46  PRO A O   1 
ATOM 151  C CB  . PRO A 1 46  ? 145.750 109.006 117.062 1.00 122.19 ? 46  PRO A CB  1 
ATOM 152  C CG  . PRO A 1 46  ? 145.754 109.018 118.523 1.00 127.47 ? 46  PRO A CG  1 
ATOM 153  C CD  . PRO A 1 46  ? 146.731 110.078 118.903 1.00 124.07 ? 46  PRO A CD  1 
ATOM 154  N N   . LEU A 1 47  ? 143.835 111.565 117.421 1.00 124.11 ? 47  LEU A N   1 
ATOM 155  C CA  . LEU A 1 47  ? 142.573 112.263 117.202 1.00 125.89 ? 47  LEU A CA  1 
ATOM 156  C C   . LEU A 1 47  ? 142.794 113.591 116.490 1.00 131.74 ? 47  LEU A C   1 
ATOM 157  O O   . LEU A 1 47  ? 142.037 113.947 115.578 1.00 140.67 ? 47  LEU A O   1 
ATOM 158  C CB  . LEU A 1 47  ? 141.856 112.481 118.532 1.00 122.02 ? 47  LEU A CB  1 
ATOM 159  C CG  . LEU A 1 47  ? 141.211 111.250 119.171 1.00 122.59 ? 47  LEU A CG  1 
ATOM 160  C CD1 . LEU A 1 47  ? 140.222 111.666 120.241 1.00 129.97 ? 47  LEU A CD1 1 
ATOM 161  C CD2 . LEU A 1 47  ? 140.532 110.391 118.122 1.00 125.94 ? 47  LEU A CD2 1 
ATOM 162  N N   . LEU A 1 48  ? 143.826 114.336 116.891 1.00 129.10 ? 48  LEU A N   1 
ATOM 163  C CA  . LEU A 1 48  ? 144.130 115.598 116.228 1.00 128.82 ? 48  LEU A CA  1 
ATOM 164  C C   . LEU A 1 48  ? 144.510 115.375 114.770 1.00 132.36 ? 48  LEU A C   1 
ATOM 165  O O   . LEU A 1 48  ? 144.056 116.108 113.881 1.00 141.69 ? 48  LEU A O   1 
ATOM 166  C CB  . LEU A 1 48  ? 145.250 116.322 116.971 1.00 125.37 ? 48  LEU A CB  1 
ATOM 167  C CG  . LEU A 1 48  ? 145.888 117.509 116.253 1.00 129.75 ? 48  LEU A CG  1 
ATOM 168  C CD1 . LEU A 1 48  ? 145.116 118.779 116.552 1.00 132.25 ? 48  LEU A CD1 1 
ATOM 169  C CD2 . LEU A 1 48  ? 147.343 117.656 116.659 1.00 133.00 ? 48  LEU A CD2 1 
ATOM 170  N N   . LEU A 1 49  ? 145.329 114.356 114.503 1.00 125.03 ? 49  LEU A N   1 
ATOM 171  C CA  . LEU A 1 49  ? 145.707 114.064 113.124 1.00 124.07 ? 49  LEU A CA  1 
ATOM 172  C C   . LEU A 1 49  ? 144.503 113.630 112.297 1.00 131.37 ? 49  LEU A C   1 
ATOM 173  O O   . LEU A 1 49  ? 144.383 114.003 111.125 1.00 134.20 ? 49  LEU A O   1 
ATOM 174  C CB  . LEU A 1 49  ? 146.797 112.997 113.094 1.00 127.35 ? 49  LEU A CB  1 
ATOM 175  C CG  . LEU A 1 49  ? 148.131 113.434 113.696 1.00 128.49 ? 49  LEU A CG  1 
ATOM 176  C CD1 . LEU A 1 49  ? 149.147 112.310 113.623 1.00 134.18 ? 49  LEU A CD1 1 
ATOM 177  C CD2 . LEU A 1 49  ? 148.648 114.676 112.996 1.00 128.47 ? 49  LEU A CD2 1 
ATOM 178  N N   . MET A 1 50  ? 143.603 112.841 112.887 1.00 148.76 ? 50  MET A N   1 
ATOM 179  C CA  . MET A 1 50  ? 142.403 112.414 112.174 1.00 146.35 ? 50  MET A CA  1 
ATOM 180  C C   . MET A 1 50  ? 141.495 113.595 111.860 1.00 149.34 ? 50  MET A C   1 
ATOM 181  O O   . MET A 1 50  ? 140.891 113.654 110.782 1.00 155.69 ? 50  MET A O   1 
ATOM 182  C CB  . MET A 1 50  ? 141.656 111.364 112.997 1.00 144.34 ? 50  MET A CB  1 
ATOM 183  C CG  . MET A 1 50  ? 140.277 111.022 112.468 1.00 149.89 ? 50  MET A CG  1 
ATOM 184  S SD  . MET A 1 50  ? 139.159 110.484 113.771 1.00 161.99 ? 50  MET A SD  1 
ATOM 185  C CE  . MET A 1 50  ? 138.272 112.003 114.099 1.00 155.19 ? 50  MET A CE  1 
ATOM 186  N N   . SER A 1 51  ? 141.369 114.536 112.797 1.00 138.08 ? 51  SER A N   1 
ATOM 187  C CA  . SER A 1 51  ? 140.579 115.730 112.528 1.00 138.82 ? 51  SER A CA  1 
ATOM 188  C C   . SER A 1 51  ? 141.221 116.611 111.468 1.00 140.91 ? 51  SER A C   1 
ATOM 189  O O   . SER A 1 51  ? 140.500 117.233 110.681 1.00 144.97 ? 51  SER A O   1 
ATOM 190  C CB  . SER A 1 51  ? 140.365 116.531 113.809 1.00 141.55 ? 51  SER A CB  1 
ATOM 191  O OG  . SER A 1 51  ? 141.493 116.444 114.656 1.00 149.91 ? 51  SER A OG  1 
ATOM 192  N N   . LEU A 1 52  ? 142.549 116.677 111.421 1.00 138.48 ? 52  LEU A N   1 
ATOM 193  C CA  . LEU A 1 52  ? 143.233 117.426 110.374 1.00 135.81 ? 52  LEU A CA  1 
ATOM 194  C C   . LEU A 1 52  ? 143.079 116.801 108.996 1.00 135.03 ? 52  LEU A C   1 
ATOM 195  O O   . LEU A 1 52  ? 143.357 117.469 107.996 1.00 140.03 ? 52  LEU A O   1 
ATOM 196  C CB  . LEU A 1 52  ? 144.722 117.568 110.702 1.00 141.99 ? 52  LEU A CB  1 
ATOM 197  C CG  . LEU A 1 52  ? 145.098 118.564 111.800 1.00 144.75 ? 52  LEU A CG  1 
ATOM 198  C CD1 . LEU A 1 52  ? 146.531 119.031 111.612 1.00 142.95 ? 52  LEU A CD1 1 
ATOM 199  C CD2 . LEU A 1 52  ? 144.144 119.749 111.817 1.00 140.26 ? 52  LEU A CD2 1 
ATOM 200  N N   . ALA A 1 53  ? 142.644 115.544 108.914 1.00 144.27 ? 53  ALA A N   1 
ATOM 201  C CA  . ALA A 1 53  ? 142.369 114.899 107.638 1.00 150.22 ? 53  ALA A CA  1 
ATOM 202  C C   . ALA A 1 53  ? 140.896 114.906 107.266 1.00 154.83 ? 53  ALA A C   1 
ATOM 203  O O   . ALA A 1 53  ? 140.573 115.022 106.084 1.00 159.40 ? 53  ALA A O   1 
ATOM 204  C CB  . ALA A 1 53  ? 142.871 113.450 107.651 1.00 151.02 ? 53  ALA A CB  1 
ATOM 205  N N   . PHE A 1 54  ? 140.001 114.776 108.246 1.00 160.12 ? 54  PHE A N   1 
ATOM 206  C CA  . PHE A 1 54  ? 138.575 114.920 107.973 1.00 157.37 ? 54  PHE A CA  1 
ATOM 207  C C   . PHE A 1 54  ? 138.223 116.327 107.513 1.00 159.12 ? 54  PHE A C   1 
ATOM 208  O O   . PHE A 1 54  ? 137.425 116.492 106.584 1.00 162.52 ? 54  PHE A O   1 
ATOM 209  C CB  . PHE A 1 54  ? 137.758 114.564 109.214 1.00 160.74 ? 54  PHE A CB  1 
ATOM 210  C CG  . PHE A 1 54  ? 137.232 113.161 109.215 1.00 162.96 ? 54  PHE A CG  1 
ATOM 211  C CD1 . PHE A 1 54  ? 136.321 112.756 110.175 1.00 165.63 ? 54  PHE A CD1 1 
ATOM 212  C CD2 . PHE A 1 54  ? 137.617 112.259 108.241 1.00 161.60 ? 54  PHE A CD2 1 
ATOM 213  C CE1 . PHE A 1 54  ? 135.824 111.468 110.179 1.00 166.22 ? 54  PHE A CE1 1 
ATOM 214  C CE2 . PHE A 1 54  ? 137.119 110.972 108.237 1.00 165.07 ? 54  PHE A CE2 1 
ATOM 215  C CZ  . PHE A 1 54  ? 136.223 110.577 109.209 1.00 165.50 ? 54  PHE A CZ  1 
ATOM 216  N N   . ALA A 1 55  ? 138.817 117.344 108.129 1.00 170.77 ? 55  ALA A N   1 
ATOM 217  C CA  . ALA A 1 55  ? 138.434 118.728 107.898 1.00 175.59 ? 55  ALA A CA  1 
ATOM 218  C C   . ALA A 1 55  ? 138.967 119.281 106.586 1.00 176.12 ? 55  ALA A C   1 
ATOM 219  O O   . ALA A 1 55  ? 138.635 120.414 106.228 1.00 180.49 ? 55  ALA A O   1 
ATOM 220  C CB  . ALA A 1 55  ? 138.911 119.608 109.055 1.00 178.15 ? 55  ALA A CB  1 
ATOM 221  N N   . GLN A 1 56  ? 139.784 118.522 105.865 1.00 153.25 ? 56  GLN A N   1 
ATOM 222  C CA  . GLN A 1 56  ? 140.315 118.982 104.589 1.00 152.78 ? 56  GLN A CA  1 
ATOM 223  C C   . GLN A 1 56  ? 139.591 118.388 103.395 1.00 154.28 ? 56  GLN A C   1 
ATOM 224  O O   . GLN A 1 56  ? 139.339 119.099 102.419 1.00 160.93 ? 56  GLN A O   1 
ATOM 225  C CB  . GLN A 1 56  ? 141.827 118.688 104.517 1.00 149.04 ? 56  GLN A CB  1 
ATOM 226  C CG  . GLN A 1 56  ? 142.461 118.438 103.135 1.00 152.15 ? 56  GLN A CG  1 
ATOM 227  C CD  . GLN A 1 56  ? 142.186 117.054 102.564 1.00 158.94 ? 56  GLN A CD  1 
ATOM 228  O OE1 . GLN A 1 56  ? 141.847 116.126 103.296 1.00 159.94 ? 56  GLN A OE1 1 
ATOM 229  N NE2 . GLN A 1 56  ? 142.314 116.922 101.249 1.00 160.76 ? 56  GLN A NE2 1 
ATOM 230  N N   . GLU A 1 57  ? 139.254 117.096 103.438 1.00 178.55 ? 57  GLU A N   1 
ATOM 231  C CA  . GLU A 1 57  ? 138.596 116.470 102.298 1.00 185.01 ? 57  GLU A CA  1 
ATOM 232  C C   . GLU A 1 57  ? 137.121 116.853 102.215 1.00 188.87 ? 57  GLU A C   1 
ATOM 233  O O   . GLU A 1 57  ? 136.552 116.863 101.120 1.00 192.87 ? 57  GLU A O   1 
ATOM 234  C CB  . GLU A 1 57  ? 138.837 114.952 102.332 1.00 187.17 ? 57  GLU A CB  1 
ATOM 235  C CG  . GLU A 1 57  ? 138.144 114.093 103.392 1.00 190.46 ? 57  GLU A CG  1 
ATOM 236  C CD  . GLU A 1 57  ? 136.679 113.830 103.120 1.00 192.11 ? 57  GLU A CD  1 
ATOM 237  O OE1 . GLU A 1 57  ? 135.959 113.473 104.074 1.00 194.32 ? 57  GLU A OE1 1 
ATOM 238  O OE2 . GLU A 1 57  ? 136.247 113.977 101.959 1.00 192.48 ? 57  GLU A OE2 1 
ATOM 239  N N   . PHE A 1 58  ? 136.486 117.180 103.344 1.00 192.45 ? 58  PHE A N   1 
ATOM 240  C CA  . PHE A 1 58  ? 135.173 117.819 103.280 1.00 192.19 ? 58  PHE A CA  1 
ATOM 241  C C   . PHE A 1 58  ? 135.259 119.201 102.647 1.00 192.68 ? 58  PHE A C   1 
ATOM 242  O O   . PHE A 1 58  ? 134.310 119.652 101.994 1.00 193.26 ? 58  PHE A O   1 
ATOM 243  C CB  . PHE A 1 58  ? 134.558 117.913 104.676 1.00 189.86 ? 58  PHE A CB  1 
ATOM 244  C CG  . PHE A 1 58  ? 133.784 116.693 105.079 1.00 193.45 ? 58  PHE A CG  1 
ATOM 245  C CD1 . PHE A 1 58  ? 132.999 116.701 106.220 1.00 193.12 ? 58  PHE A CD1 1 
ATOM 246  C CD2 . PHE A 1 58  ? 133.793 115.557 104.287 1.00 196.29 ? 58  PHE A CD2 1 
ATOM 247  C CE1 . PHE A 1 58  ? 132.280 115.584 106.588 1.00 195.54 ? 58  PHE A CE1 1 
ATOM 248  C CE2 . PHE A 1 58  ? 133.066 114.441 104.644 1.00 198.15 ? 58  PHE A CE2 1 
ATOM 249  C CZ  . PHE A 1 58  ? 132.305 114.454 105.796 1.00 197.66 ? 58  PHE A CZ  1 
ATOM 250  N N   . SER A 1 59  ? 136.387 119.884 102.823 1.00 189.28 ? 59  SER A N   1 
ATOM 251  C CA  . SER A 1 59  ? 136.518 121.242 102.307 1.00 191.67 ? 59  SER A CA  1 
ATOM 252  C C   . SER A 1 59  ? 136.806 121.241 100.812 1.00 193.36 ? 59  SER A C   1 
ATOM 253  O O   . SER A 1 59  ? 136.114 121.910 100.034 1.00 194.36 ? 59  SER A O   1 
ATOM 254  C CB  . SER A 1 59  ? 137.619 121.976 103.067 1.00 191.62 ? 59  SER A CB  1 
ATOM 255  O OG  . SER A 1 59  ? 138.899 121.606 102.583 1.00 192.78 ? 59  SER A OG  1 
ATOM 256  N N   . SER A 1 60  ? 137.821 120.487 100.388 1.00 171.52 ? 60  SER A N   1 
ATOM 257  C CA  . SER A 1 60  ? 138.232 120.504 98.988  1.00 166.65 ? 60  SER A CA  1 
ATOM 258  C C   . SER A 1 60  ? 137.249 119.783 98.076  1.00 168.62 ? 60  SER A C   1 
ATOM 259  O O   . SER A 1 60  ? 137.357 119.905 96.852  1.00 170.30 ? 60  SER A O   1 
ATOM 260  C CB  . SER A 1 60  ? 139.624 119.888 98.842  1.00 163.67 ? 60  SER A CB  1 
ATOM 261  O OG  . SER A 1 60  ? 139.808 119.339 97.548  1.00 164.09 ? 60  SER A OG  1 
ATOM 262  N N   . GLY A 1 61  ? 136.298 119.039 98.635  1.00 171.95 ? 61  GLY A N   1 
ATOM 263  C CA  . GLY A 1 61  ? 135.346 118.305 97.826  1.00 171.37 ? 61  GLY A CA  1 
ATOM 264  C C   . GLY A 1 61  ? 135.770 116.871 97.598  1.00 171.59 ? 61  GLY A C   1 
ATOM 265  O O   . GLY A 1 61  ? 135.860 116.087 98.545  1.00 173.35 ? 61  GLY A O   1 
ATOM 266  N N   . SER A 1 62  ? 136.022 116.511 96.350  1.00 162.26 ? 62  SER A N   1 
ATOM 267  C CA  . SER A 1 62  ? 136.513 115.165 96.094  1.00 160.87 ? 62  SER A CA  1 
ATOM 268  C C   . SER A 1 62  ? 137.993 115.070 96.461  1.00 157.12 ? 62  SER A C   1 
ATOM 269  O O   . SER A 1 62  ? 138.758 116.003 96.203  1.00 159.69 ? 62  SER A O   1 
ATOM 270  C CB  . SER A 1 62  ? 136.319 114.788 94.629  1.00 161.19 ? 62  SER A CB  1 
ATOM 271  O OG  . SER A 1 62  ? 137.316 113.875 94.205  1.00 163.19 ? 62  SER A OG  1 
ATOM 272  N N   . PRO A 1 63  ? 138.423 113.962 97.066  1.00 119.03 ? 63  PRO A N   1 
ATOM 273  C CA  . PRO A 1 63  ? 139.845 113.769 97.358  1.00 120.93 ? 63  PRO A CA  1 
ATOM 274  C C   . PRO A 1 63  ? 140.660 113.234 96.193  1.00 122.88 ? 63  PRO A C   1 
ATOM 275  O O   . PRO A 1 63  ? 141.798 112.807 96.404  1.00 134.31 ? 63  PRO A O   1 
ATOM 276  C CB  . PRO A 1 63  ? 139.810 112.751 98.506  1.00 122.25 ? 63  PRO A CB  1 
ATOM 277  C CG  . PRO A 1 63  ? 138.598 111.942 98.231  1.00 122.49 ? 63  PRO A CG  1 
ATOM 278  C CD  . PRO A 1 63  ? 137.595 112.855 97.573  1.00 119.11 ? 63  PRO A CD  1 
ATOM 279  N N   . ILE A 1 64  ? 140.112 113.244 94.981  1.00 103.36 ? 64  ILE A N   1 
ATOM 280  C CA  . ILE A 1 64  ? 140.798 112.717 93.808  1.00 104.96 ? 64  ILE A CA  1 
ATOM 281  C C   . ILE A 1 64  ? 140.167 113.356 92.582  1.00 111.06 ? 64  ILE A C   1 
ATOM 282  O O   . ILE A 1 64  ? 138.949 113.538 92.520  1.00 121.21 ? 64  ILE A O   1 
ATOM 283  C CB  . ILE A 1 64  ? 140.713 111.173 93.764  1.00 105.58 ? 64  ILE A CB  1 
ATOM 284  C CG1 . ILE A 1 64  ? 141.194 110.630 92.420  1.00 105.18 ? 64  ILE A CG1 1 
ATOM 285  C CG2 . ILE A 1 64  ? 139.294 110.720 94.027  1.00 114.87 ? 64  ILE A CG2 1 
ATOM 286  C CD1 . ILE A 1 64  ? 141.086 109.131 92.298  1.00 111.96 ? 64  ILE A CD1 1 
ATOM 287  N N   . SER A 1 65  ? 141.001 113.713 91.610  1.00 112.90 ? 65  SER A N   1 
ATOM 288  C CA  . SER A 1 65  ? 140.519 114.280 90.362  1.00 108.70 ? 65  SER A CA  1 
ATOM 289  C C   . SER A 1 65  ? 140.927 113.377 89.208  1.00 106.15 ? 65  SER A C   1 
ATOM 290  O O   . SER A 1 65  ? 141.864 112.586 89.321  1.00 116.53 ? 65  SER A O   1 
ATOM 291  C CB  . SER A 1 65  ? 141.060 115.695 90.149  1.00 117.89 ? 65  SER A CB  1 
ATOM 292  O OG  . SER A 1 65  ? 140.892 116.475 91.317  1.00 119.12 ? 65  SER A OG  1 
ATOM 293  N N   . CYS A 1 66  ? 140.201 113.478 88.100  1.00 105.98 ? 66  CYS A N   1 
ATOM 294  C CA  . CYS A 1 66  ? 140.511 112.674 86.926  1.00 116.43 ? 66  CYS A CA  1 
ATOM 295  C C   . CYS A 1 66  ? 140.338 113.514 85.673  1.00 116.34 ? 66  CYS A C   1 
ATOM 296  O O   . CYS A 1 66  ? 139.387 114.290 85.557  1.00 121.94 ? 66  CYS A O   1 
ATOM 297  C CB  . CYS A 1 66  ? 139.629 111.426 86.848  1.00 124.92 ? 66  CYS A CB  1 
ATOM 298  S SG  . CYS A 1 66  ? 139.891 110.253 88.197  1.00 159.04 ? 66  CYS A SG  1 
ATOM 299  N N   . PHE A 1 67  ? 141.266 113.345 84.731  1.00 100.62 ? 67  PHE A N   1 
ATOM 300  C CA  . PHE A 1 67  ? 141.268 114.113 83.489  1.00 97.08  ? 67  PHE A CA  1 
ATOM 301  C C   . PHE A 1 67  ? 140.454 113.357 82.445  1.00 104.17 ? 67  PHE A C   1 
ATOM 302  O O   . PHE A 1 67  ? 140.982 112.687 81.557  1.00 114.39 ? 67  PHE A O   1 
ATOM 303  C CB  . PHE A 1 67  ? 142.695 114.361 83.021  1.00 102.53 ? 67  PHE A CB  1 
ATOM 304  C CG  . PHE A 1 67  ? 142.822 115.495 82.056  1.00 97.88  ? 67  PHE A CG  1 
ATOM 305  C CD1 . PHE A 1 67  ? 142.823 116.802 82.504  1.00 99.46  ? 67  PHE A CD1 1 
ATOM 306  C CD2 . PHE A 1 67  ? 142.942 115.256 80.700  1.00 103.14 ? 67  PHE A CD2 1 
ATOM 307  C CE1 . PHE A 1 67  ? 142.941 117.849 81.619  1.00 110.99 ? 67  PHE A CE1 1 
ATOM 308  C CE2 . PHE A 1 67  ? 143.059 116.300 79.812  1.00 104.31 ? 67  PHE A CE2 1 
ATOM 309  C CZ  . PHE A 1 67  ? 143.057 117.598 80.271  1.00 108.76 ? 67  PHE A CZ  1 
ATOM 310  N N   . SER A 1 68  ? 139.136 113.473 82.565  1.00 97.11  ? 68  SER A N   1 
ATOM 311  C CA  . SER A 1 68  ? 138.234 112.838 81.626  1.00 93.74  ? 68  SER A CA  1 
ATOM 312  C C   . SER A 1 68  ? 138.330 113.515 80.260  1.00 96.38  ? 68  SER A C   1 
ATOM 313  O O   . SER A 1 68  ? 138.736 114.673 80.161  1.00 112.69 ? 68  SER A O   1 
ATOM 314  C CB  . SER A 1 68  ? 136.803 112.908 82.149  1.00 100.81 ? 68  SER A CB  1 
ATOM 315  O OG  . SER A 1 68  ? 136.527 114.187 82.686  1.00 111.69 ? 68  SER A OG  1 
ATOM 316  N N   . PRO A 1 69  ? 137.977 112.804 79.190  1.00 106.93 ? 69  PRO A N   1 
ATOM 317  C CA  . PRO A 1 69  ? 137.997 113.417 77.855  1.00 115.57 ? 69  PRO A CA  1 
ATOM 318  C C   . PRO A 1 69  ? 137.010 114.571 77.749  1.00 122.28 ? 69  PRO A C   1 
ATOM 319  O O   . PRO A 1 69  ? 136.154 114.791 78.606  1.00 127.29 ? 69  PRO A O   1 
ATOM 320  C CB  . PRO A 1 69  ? 137.612 112.262 76.928  1.00 113.38 ? 69  PRO A CB  1 
ATOM 321  C CG  . PRO A 1 69  ? 138.002 111.041 77.676  1.00 118.28 ? 69  PRO A CG  1 
ATOM 322  C CD  . PRO A 1 69  ? 137.743 111.353 79.117  1.00 114.73 ? 69  PRO A CD  1 
ATOM 323  N N   . SER A 1 70  ? 137.145 115.321 76.653  1.00 134.03 ? 70  SER A N   1 
ATOM 324  C CA  . SER A 1 70  ? 136.389 116.560 76.505  1.00 135.07 ? 70  SER A CA  1 
ATOM 325  C C   . SER A 1 70  ? 134.907 116.309 76.253  1.00 139.89 ? 70  SER A C   1 
ATOM 326  O O   . SER A 1 70  ? 134.069 117.124 76.655  1.00 142.96 ? 70  SER A O   1 
ATOM 327  C CB  . SER A 1 70  ? 136.979 117.399 75.375  1.00 138.01 ? 70  SER A CB  1 
ATOM 328  O OG  . SER A 1 70  ? 136.617 118.760 75.514  1.00 141.74 ? 70  SER A OG  1 
ATOM 329  N N   . ASN A 1 71  ? 134.562 115.203 75.601  1.00 131.25 ? 71  ASN A N   1 
ATOM 330  C CA  . ASN A 1 71  ? 133.183 114.924 75.202  1.00 125.55 ? 71  ASN A CA  1 
ATOM 331  C C   . ASN A 1 71  ? 132.478 113.991 76.177  1.00 124.92 ? 71  ASN A C   1 
ATOM 332  O O   . ASN A 1 71  ? 131.685 113.141 75.770  1.00 127.87 ? 71  ASN A O   1 
ATOM 333  C CB  . ASN A 1 71  ? 133.149 114.350 73.790  1.00 121.57 ? 71  ASN A CB  1 
ATOM 334  C CG  . ASN A 1 71  ? 134.121 113.206 73.599  1.00 126.73 ? 71  ASN A CG  1 
ATOM 335  O OD1 . ASN A 1 71  ? 134.770 112.764 74.546  1.00 129.67 ? 71  ASN A OD1 1 
ATOM 336  N ND2 . ASN A 1 71  ? 134.229 112.719 72.368  1.00 121.98 ? 71  ASN A ND2 1 
ATOM 337  N N   . PHE A 1 72  ? 132.751 114.125 77.473  1.00 118.54 ? 72  PHE A N   1 
ATOM 338  C CA  . PHE A 1 72  ? 132.160 113.269 78.491  1.00 121.76 ? 72  PHE A CA  1 
ATOM 339  C C   . PHE A 1 72  ? 131.015 113.933 79.246  1.00 128.88 ? 72  PHE A C   1 
ATOM 340  O O   . PHE A 1 72  ? 130.609 113.419 80.292  1.00 135.78 ? 72  PHE A O   1 
ATOM 341  C CB  . PHE A 1 72  ? 133.227 112.808 79.482  1.00 123.21 ? 72  PHE A CB  1 
ATOM 342  C CG  . PHE A 1 72  ? 133.676 111.395 79.269  1.00 120.40 ? 72  PHE A CG  1 
ATOM 343  C CD1 . PHE A 1 72  ? 134.019 110.947 78.008  1.00 122.19 ? 72  PHE A CD1 1 
ATOM 344  C CD2 . PHE A 1 72  ? 133.754 110.516 80.333  1.00 119.61 ? 72  PHE A CD2 1 
ATOM 345  C CE1 . PHE A 1 72  ? 134.431 109.647 77.811  1.00 127.21 ? 72  PHE A CE1 1 
ATOM 346  C CE2 . PHE A 1 72  ? 134.165 109.215 80.142  1.00 120.39 ? 72  PHE A CE2 1 
ATOM 347  C CZ  . PHE A 1 72  ? 134.505 108.780 78.880  1.00 126.30 ? 72  PHE A CZ  1 
ATOM 348  N N   . SER A 1 73  ? 130.496 115.049 78.746  1.00 136.91 ? 73  SER A N   1 
ATOM 349  C CA  . SER A 1 73  ? 129.356 115.764 79.355  1.00 140.39 ? 73  SER A CA  1 
ATOM 350  C C   . SER A 1 73  ? 129.746 116.137 80.788  1.00 141.00 ? 73  SER A C   1 
ATOM 351  O O   . SER A 1 73  ? 130.883 116.575 81.024  1.00 144.81 ? 73  SER A O   1 
ATOM 352  C CB  . SER A 1 73  ? 128.099 114.932 79.232  1.00 136.96 ? 73  SER A CB  1 
ATOM 353  O OG  . SER A 1 73  ? 127.833 114.245 80.441  1.00 135.01 ? 73  SER A OG  1 
ATOM 354  N N   . ILE A 1 74  ? 128.849 115.974 81.760  1.00 126.05 ? 74  ILE A N   1 
ATOM 355  C CA  . ILE A 1 74  ? 129.116 116.311 83.152  1.00 126.43 ? 74  ILE A CA  1 
ATOM 356  C C   . ILE A 1 74  ? 128.963 115.095 84.060  1.00 131.14 ? 74  ILE A C   1 
ATOM 357  O O   . ILE A 1 74  ? 129.824 114.822 84.901  1.00 138.63 ? 74  ILE A O   1 
ATOM 358  C CB  . ILE A 1 74  ? 128.212 117.465 83.636  1.00 127.54 ? 74  ILE A CB  1 
ATOM 359  C CG1 . ILE A 1 74  ? 128.374 118.685 82.729  1.00 130.39 ? 74  ILE A CG1 1 
ATOM 360  C CG2 . ILE A 1 74  ? 128.540 117.831 85.071  1.00 123.62 ? 74  ILE A CG2 1 
ATOM 361  C CD1 . ILE A 1 74  ? 127.155 118.982 81.887  1.00 131.60 ? 74  ILE A CD1 1 
ATOM 362  N N   . ARG A 1 75  ? 127.867 114.352 83.902  1.00 135.47 ? 75  ARG A N   1 
ATOM 363  C CA  . ARG A 1 75  ? 127.603 113.232 84.800  1.00 135.11 ? 75  ARG A CA  1 
ATOM 364  C C   . ARG A 1 75  ? 128.583 112.087 84.594  1.00 134.91 ? 75  ARG A C   1 
ATOM 365  O O   . ARG A 1 75  ? 128.935 111.397 85.558  1.00 142.69 ? 75  ARG A O   1 
ATOM 366  C CB  . ARG A 1 75  ? 126.168 112.738 84.623  1.00 134.50 ? 75  ARG A CB  1 
ATOM 367  C CG  . ARG A 1 75  ? 125.109 113.727 85.079  1.00 140.33 ? 75  ARG A CG  1 
ATOM 368  C CD  . ARG A 1 75  ? 125.498 114.408 86.384  1.00 139.72 ? 75  ARG A CD  1 
ATOM 369  N NE  . ARG A 1 75  ? 125.712 113.451 87.462  1.00 141.94 ? 75  ARG A NE  1 
ATOM 370  C CZ  . ARG A 1 75  ? 124.770 113.036 88.296  1.00 143.78 ? 75  ARG A CZ  1 
ATOM 371  N NH1 . ARG A 1 75  ? 123.527 113.482 88.208  1.00 144.50 ? 75  ARG A NH1 1 
ATOM 372  N NH2 . ARG A 1 75  ? 125.080 112.155 89.241  1.00 139.86 ? 75  ARG A NH2 1 
ATOM 373  N N   . GLN A 1 76  ? 129.031 111.863 83.359  1.00 116.12 ? 76  GLN A N   1 
ATOM 374  C CA  . GLN A 1 76  ? 129.989 110.793 83.116  1.00 120.74 ? 76  GLN A CA  1 
ATOM 375  C C   . GLN A 1 76  ? 131.330 111.082 83.779  1.00 123.15 ? 76  GLN A C   1 
ATOM 376  O O   . GLN A 1 76  ? 132.000 110.155 84.244  1.00 131.44 ? 76  GLN A O   1 
ATOM 377  C CB  . GLN A 1 76  ? 130.162 110.573 81.617  1.00 119.91 ? 76  GLN A CB  1 
ATOM 378  C CG  . GLN A 1 76  ? 128.914 110.046 80.936  1.00 125.88 ? 76  GLN A CG  1 
ATOM 379  C CD  . GLN A 1 76  ? 128.826 110.455 79.481  1.00 129.75 ? 76  GLN A CD  1 
ATOM 380  O OE1 . GLN A 1 76  ? 128.598 111.621 79.167  1.00 135.05 ? 76  GLN A OE1 1 
ATOM 381  N NE2 . GLN A 1 76  ? 129.005 109.493 78.586  1.00 127.95 ? 76  GLN A NE2 1 
ATOM 382  N N   . ALA A 1 77  ? 131.730 112.354 83.841  1.00 115.19 ? 77  ALA A N   1 
ATOM 383  C CA  . ALA A 1 77  ? 132.950 112.704 84.560  1.00 118.53 ? 77  ALA A CA  1 
ATOM 384  C C   . ALA A 1 77  ? 132.824 112.385 86.045  1.00 123.64 ? 77  ALA A C   1 
ATOM 385  O O   . ALA A 1 77  ? 133.762 111.862 86.659  1.00 136.19 ? 77  ALA A O   1 
ATOM 386  C CB  . ALA A 1 77  ? 133.276 114.182 84.353  1.00 124.45 ? 77  ALA A CB  1 
ATOM 387  N N   . ALA A 1 78  ? 131.669 112.694 86.639  1.00 118.67 ? 78  ALA A N   1 
ATOM 388  C CA  . ALA A 1 78  ? 131.450 112.365 88.043  1.00 123.93 ? 78  ALA A CA  1 
ATOM 389  C C   . ALA A 1 78  ? 131.443 110.858 88.258  1.00 126.92 ? 78  ALA A C   1 
ATOM 390  O O   . ALA A 1 78  ? 131.953 110.364 89.272  1.00 131.21 ? 78  ALA A O   1 
ATOM 391  C CB  . ALA A 1 78  ? 130.140 112.982 88.529  1.00 127.06 ? 78  ALA A CB  1 
ATOM 392  N N   . TYR A 1 79  ? 130.860 110.112 87.317  1.00 113.43 ? 79  TYR A N   1 
ATOM 393  C CA  . TYR A 1 79  ? 130.880 108.657 87.411  1.00 113.09 ? 79  TYR A CA  1 
ATOM 394  C C   . TYR A 1 79  ? 132.305 108.124 87.362  1.00 115.40 ? 79  TYR A C   1 
ATOM 395  O O   . TYR A 1 79  ? 132.660 107.218 88.122  1.00 120.22 ? 79  TYR A O   1 
ATOM 396  C CB  . TYR A 1 79  ? 130.044 108.047 86.289  1.00 110.95 ? 79  TYR A CB  1 
ATOM 397  C CG  . TYR A 1 79  ? 130.197 106.551 86.155  1.00 107.69 ? 79  TYR A CG  1 
ATOM 398  C CD1 . TYR A 1 79  ? 129.529 105.690 87.008  1.00 117.69 ? 79  TYR A CD1 1 
ATOM 399  C CD2 . TYR A 1 79  ? 131.001 106.001 85.168  1.00 108.66 ? 79  TYR A CD2 1 
ATOM 400  C CE1 . TYR A 1 79  ? 129.664 104.324 86.889  1.00 122.09 ? 79  TYR A CE1 1 
ATOM 401  C CE2 . TYR A 1 79  ? 131.141 104.638 85.044  1.00 118.05 ? 79  TYR A CE2 1 
ATOM 402  C CZ  . TYR A 1 79  ? 130.470 103.805 85.905  1.00 120.64 ? 79  TYR A CZ  1 
ATOM 403  O OH  . TYR A 1 79  ? 130.606 102.443 85.785  1.00 115.76 ? 79  TYR A OH  1 
ATOM 404  N N   . VAL A 1 80  ? 133.130 108.675 86.472  1.00 101.95 ? 80  VAL A N   1 
ATOM 405  C CA  . VAL A 1 80  ? 134.525 108.255 86.382  1.00 94.55  ? 80  VAL A CA  1 
ATOM 406  C C   . VAL A 1 80  ? 135.255 108.559 87.682  1.00 96.75  ? 80  VAL A C   1 
ATOM 407  O O   . VAL A 1 80  ? 136.014 107.725 88.197  1.00 109.09 ? 80  VAL A O   1 
ATOM 408  C CB  . VAL A 1 80  ? 135.203 108.929 85.174  1.00 92.44  ? 80  VAL A CB  1 
ATOM 409  C CG1 . VAL A 1 80  ? 136.705 109.012 85.373  1.00 94.90  ? 80  VAL A CG1 1 
ATOM 410  C CG2 . VAL A 1 80  ? 134.875 108.178 83.900  1.00 96.71  ? 80  VAL A CG2 1 
ATOM 411  N N   . ASP A 1 81  ? 135.027 109.750 88.239  1.00 116.69 ? 81  ASP A N   1 
ATOM 412  C CA  . ASP A 1 81  ? 135.657 110.124 89.503  1.00 119.08 ? 81  ASP A CA  1 
ATOM 413  C C   . ASP A 1 81  ? 135.284 109.152 90.614  1.00 122.10 ? 81  ASP A C   1 
ATOM 414  O O   . ASP A 1 81  ? 136.156 108.634 91.321  1.00 132.64 ? 81  ASP A O   1 
ATOM 415  C CB  . ASP A 1 81  ? 135.246 111.545 89.889  1.00 128.30 ? 81  ASP A CB  1 
ATOM 416  C CG  . ASP A 1 81  ? 136.252 112.582 89.448  1.00 140.68 ? 81  ASP A CG  1 
ATOM 417  O OD1 . ASP A 1 81  ? 137.256 112.204 88.816  1.00 143.07 ? 81  ASP A OD1 1 
ATOM 418  O OD2 . ASP A 1 81  ? 136.036 113.779 89.735  1.00 144.44 ? 81  ASP A OD2 1 
ATOM 419  N N   . SER A 1 82  ? 133.985 108.888 90.774  1.00 111.61 ? 82  SER A N   1 
ATOM 420  C CA  . SER A 1 82  ? 133.535 108.006 91.846  1.00 117.66 ? 82  SER A CA  1 
ATOM 421  C C   . SER A 1 82  ? 134.045 106.586 91.651  1.00 114.67 ? 82  SER A C   1 
ATOM 422  O O   . SER A 1 82  ? 134.460 105.931 92.614  1.00 119.14 ? 82  SER A O   1 
ATOM 423  C CB  . SER A 1 82  ? 132.012 108.024 91.934  1.00 120.30 ? 82  SER A CB  1 
ATOM 424  O OG  . SER A 1 82  ? 131.535 109.340 92.138  1.00 127.44 ? 82  SER A OG  1 
ATOM 425  N N   . SER A 1 83  ? 134.028 106.092 90.410  1.00 110.07 ? 83  SER A N   1 
ATOM 426  C CA  . SER A 1 83  ? 134.494 104.735 90.152  1.00 110.85 ? 83  SER A CA  1 
ATOM 427  C C   . SER A 1 83  ? 135.980 104.592 90.443  1.00 113.74 ? 83  SER A C   1 
ATOM 428  O O   . SER A 1 83  ? 136.405 103.603 91.050  1.00 122.86 ? 83  SER A O   1 
ATOM 429  C CB  . SER A 1 83  ? 134.197 104.345 88.706  1.00 123.26 ? 83  SER A CB  1 
ATOM 430  O OG  . SER A 1 83  ? 134.823 103.117 88.382  1.00 124.52 ? 83  SER A OG  1 
ATOM 431  N N   . CYS A 1 84  ? 136.790 105.566 90.021  1.00 122.36 ? 84  CYS A N   1 
ATOM 432  C CA  . CYS A 1 84  ? 138.220 105.473 90.281  1.00 124.93 ? 84  CYS A CA  1 
ATOM 433  C C   . CYS A 1 84  ? 138.532 105.641 91.761  1.00 125.40 ? 84  CYS A C   1 
ATOM 434  O O   . CYS A 1 84  ? 139.481 105.027 92.262  1.00 128.70 ? 84  CYS A O   1 
ATOM 435  C CB  . CYS A 1 84  ? 138.977 106.504 89.447  1.00 129.91 ? 84  CYS A CB  1 
ATOM 436  S SG  . CYS A 1 84  ? 139.059 106.108 87.684  1.00 146.54 ? 84  CYS A SG  1 
ATOM 437  N N   . TRP A 1 85  ? 137.756 106.457 92.477  1.00 112.35 ? 85  TRP A N   1 
ATOM 438  C CA  . TRP A 1 85  ? 137.969 106.581 93.916  1.00 107.73 ? 85  TRP A CA  1 
ATOM 439  C C   . TRP A 1 85  ? 137.595 105.295 94.641  1.00 106.47 ? 85  TRP A C   1 
ATOM 440  O O   . TRP A 1 85  ? 138.270 104.899 95.597  1.00 113.29 ? 85  TRP A O   1 
ATOM 441  C CB  . TRP A 1 85  ? 137.170 107.758 94.468  1.00 112.87 ? 85  TRP A CB  1 
ATOM 442  C CG  . TRP A 1 85  ? 137.203 107.876 95.962  1.00 110.27 ? 85  TRP A CG  1 
ATOM 443  C CD1 . TRP A 1 85  ? 136.137 107.816 96.807  1.00 114.13 ? 85  TRP A CD1 1 
ATOM 444  C CD2 . TRP A 1 85  ? 138.356 108.089 96.785  1.00 112.97 ? 85  TRP A CD2 1 
ATOM 445  N NE1 . TRP A 1 85  ? 136.553 107.974 98.106  1.00 119.00 ? 85  TRP A NE1 1 
ATOM 446  C CE2 . TRP A 1 85  ? 137.912 108.143 98.119  1.00 117.07 ? 85  TRP A CE2 1 
ATOM 447  C CE3 . TRP A 1 85  ? 139.721 108.236 96.524  1.00 112.61 ? 85  TRP A CE3 1 
ATOM 448  C CZ2 . TRP A 1 85  ? 138.780 108.337 99.187  1.00 113.51 ? 85  TRP A CZ2 1 
ATOM 449  C CZ3 . TRP A 1 85  ? 140.581 108.429 97.587  1.00 110.09 ? 85  TRP A CZ3 1 
ATOM 450  C CH2 . TRP A 1 85  ? 140.108 108.477 98.901  1.00 110.66 ? 85  TRP A CH2 1 
ATOM 451  N N   . ASP A 1 86  ? 136.520 104.638 94.208  1.00 125.24 ? 86  ASP A N   1 
ATOM 452  C CA  . ASP A 1 86  ? 136.114 103.390 94.844  1.00 125.57 ? 86  ASP A CA  1 
ATOM 453  C C   . ASP A 1 86  ? 137.106 102.271 94.553  1.00 123.76 ? 86  ASP A C   1 
ATOM 454  O O   . ASP A 1 86  ? 137.468 101.507 95.454  1.00 123.81 ? 86  ASP A O   1 
ATOM 455  C CB  . ASP A 1 86  ? 134.711 103.002 94.380  1.00 134.94 ? 86  ASP A CB  1 
ATOM 456  C CG  . ASP A 1 86  ? 134.406 101.535 94.601  1.00 137.62 ? 86  ASP A CG  1 
ATOM 457  O OD1 . ASP A 1 86  ? 134.633 101.037 95.722  1.00 139.84 ? 86  ASP A OD1 1 
ATOM 458  O OD2 . ASP A 1 86  ? 133.940 100.876 93.646  1.00 134.99 ? 86  ASP A OD2 1 
ATOM 459  N N   . SER A 1 87  ? 137.556 102.158 93.303  1.00 128.01 ? 87  SER A N   1 
ATOM 460  C CA  . SER A 1 87  ? 138.485 101.089 92.947  1.00 127.26 ? 87  SER A CA  1 
ATOM 461  C C   . SER A 1 87  ? 139.852 101.322 93.575  1.00 128.26 ? 87  SER A C   1 
ATOM 462  O O   . SER A 1 87  ? 140.333 100.501 94.365  1.00 135.81 ? 87  SER A O   1 
ATOM 463  C CB  . SER A 1 87  ? 138.600 100.976 91.426  1.00 130.56 ? 87  SER A CB  1 
ATOM 464  O OG  . SER A 1 87  ? 137.400 100.478 90.864  1.00 137.54 ? 87  SER A OG  1 
ATOM 465  N N   . LEU A 1 88  ? 140.488 102.445 93.232  1.00 136.89 ? 88  LEU A N   1 
ATOM 466  C CA  . LEU A 1 88  ? 141.794 102.832 93.772  1.00 141.19 ? 88  LEU A CA  1 
ATOM 467  C C   . LEU A 1 88  ? 142.845 101.755 93.506  1.00 139.84 ? 88  LEU A C   1 
ATOM 468  O O   . LEU A 1 88  ? 143.488 101.240 94.423  1.00 144.02 ? 88  LEU A O   1 
ATOM 469  C CB  . LEU A 1 88  ? 141.696 103.154 95.265  1.00 138.20 ? 88  LEU A CB  1 
ATOM 470  C CG  . LEU A 1 88  ? 142.587 104.275 95.795  1.00 135.44 ? 88  LEU A CG  1 
ATOM 471  C CD1 . LEU A 1 88  ? 142.504 105.490 94.898  1.00 140.46 ? 88  LEU A CD1 1 
ATOM 472  C CD2 . LEU A 1 88  ? 142.174 104.634 97.207  1.00 136.92 ? 88  LEU A CD2 1 
ATOM 473  N N   . LEU A 1 89  ? 143.014 101.413 92.231  1.00 132.94 ? 89  LEU A N   1 
ATOM 474  C CA  . LEU A 1 89  ? 143.940 100.359 91.826  1.00 139.19 ? 89  LEU A CA  1 
ATOM 475  C C   . LEU A 1 89  ? 144.699 100.826 90.593  1.00 136.94 ? 89  LEU A C   1 
ATOM 476  O O   . LEU A 1 89  ? 144.115 100.947 89.512  1.00 138.81 ? 89  LEU A O   1 
ATOM 477  C CB  . LEU A 1 89  ? 143.195 99.054  91.544  1.00 144.94 ? 89  LEU A CB  1 
ATOM 478  C CG  . LEU A 1 89  ? 144.044 97.862  91.102  1.00 147.92 ? 89  LEU A CG  1 
ATOM 479  C CD1 . LEU A 1 89  ? 144.977 97.423  92.218  1.00 142.82 ? 89  LEU A CD1 1 
ATOM 480  C CD2 . LEU A 1 89  ? 143.156 96.712  90.659  1.00 145.06 ? 89  LEU A CD2 1 
ATOM 481  N N   . HIS A 1 90  ? 145.995 101.081 90.752  1.00 138.03 ? 90  HIS A N   1 
ATOM 482  C CA  . HIS A 1 90  ? 146.838 101.474 89.632  1.00 141.41 ? 90  HIS A CA  1 
ATOM 483  C C   . HIS A 1 90  ? 147.090 100.268 88.738  1.00 145.15 ? 90  HIS A C   1 
ATOM 484  O O   . HIS A 1 90  ? 147.484 99.201  89.218  1.00 148.13 ? 90  HIS A O   1 
ATOM 485  C CB  . HIS A 1 90  ? 148.159 102.053 90.139  1.00 141.87 ? 90  HIS A CB  1 
ATOM 486  C CG  . HIS A 1 90  ? 149.164 102.313 89.062  1.00 143.63 ? 90  HIS A CG  1 
ATOM 487  N ND1 . HIS A 1 90  ? 148.809 102.686 87.783  1.00 146.65 ? 90  HIS A ND1 1 
ATOM 488  C CD2 . HIS A 1 90  ? 150.516 102.260 89.075  1.00 143.99 ? 90  HIS A CD2 1 
ATOM 489  C CE1 . HIS A 1 90  ? 149.900 102.846 87.055  1.00 145.11 ? 90  HIS A CE1 1 
ATOM 490  N NE2 . HIS A 1 90  ? 150.949 102.595 87.816  1.00 143.34 ? 90  HIS A NE2 1 
ATOM 491  N N   . HIS A 1 91  ? 146.863 100.437 87.436  1.00 157.29 ? 91  HIS A N   1 
ATOM 492  C CA  . HIS A 1 91  ? 146.958 99.310  86.515  1.00 159.07 ? 91  HIS A CA  1 
ATOM 493  C C   . HIS A 1 91  ? 148.400 99.043  86.096  1.00 159.54 ? 91  HIS A C   1 
ATOM 494  O O   . HIS A 1 91  ? 148.946 97.967  86.361  1.00 163.09 ? 91  HIS A O   1 
ATOM 495  C CB  . HIS A 1 91  ? 146.076 99.557  85.291  1.00 153.10 ? 91  HIS A CB  1 
ATOM 496  C CG  . HIS A 1 91  ? 144.730 98.912  85.382  1.00 157.13 ? 91  HIS A CG  1 
ATOM 497  N ND1 . HIS A 1 91  ? 143.847 99.176  86.407  1.00 156.66 ? 91  HIS A ND1 1 
ATOM 498  C CD2 . HIS A 1 91  ? 144.118 98.008  84.582  1.00 157.13 ? 91  HIS A CD2 1 
ATOM 499  C CE1 . HIS A 1 91  ? 142.746 98.465  86.231  1.00 157.23 ? 91  HIS A CE1 1 
ATOM 500  N NE2 . HIS A 1 91  ? 142.887 97.748  85.131  1.00 159.62 ? 91  HIS A NE2 1 
ATOM 501  N N   . LYS A 1 92  ? 149.032 100.009 85.440  1.00 145.44 ? 92  LYS A N   1 
ATOM 502  C CA  . LYS A 1 92  ? 150.387 99.811  84.942  1.00 149.30 ? 92  LYS A CA  1 
ATOM 503  C C   . LYS A 1 92  ? 151.405 99.892  86.071  1.00 150.56 ? 92  LYS A C   1 
ATOM 504  O O   . LYS A 1 92  ? 152.249 99.010  86.222  1.00 147.48 ? 92  LYS A O   1 
ATOM 505  C CB  . LYS A 1 92  ? 150.718 100.840 83.860  1.00 149.15 ? 92  LYS A CB  1 
ATOM 506  C CG  . LYS A 1 92  ? 152.150 100.768 83.356  1.00 149.76 ? 92  LYS A CG  1 
ATOM 507  C CD  . LYS A 1 92  ? 152.457 99.414  82.740  1.00 146.50 ? 92  LYS A CD  1 
ATOM 508  C CE  . LYS A 1 92  ? 151.599 99.157  81.512  1.00 145.99 ? 92  LYS A CE  1 
ATOM 509  N NZ  . LYS A 1 92  ? 152.295 98.292  80.521  1.00 147.00 ? 92  LYS A NZ  1 
ATOM 510  N N   . LYS A 1 102 ? 151.099 98.763  93.434  1.00 119.05 ? 102 LYS A N   1 
ATOM 511  C CA  . LYS A 1 102 ? 150.054 98.541  92.444  1.00 128.69 ? 102 LYS A CA  1 
ATOM 512  C C   . LYS A 1 102 ? 148.687 98.890  93.021  1.00 129.25 ? 102 LYS A C   1 
ATOM 513  O O   . LYS A 1 102 ? 147.761 99.230  92.288  1.00 133.49 ? 102 LYS A O   1 
ATOM 514  C CB  . LYS A 1 102 ? 150.074 97.091  91.956  1.00 127.69 ? 102 LYS A CB  1 
ATOM 515  C CG  . LYS A 1 102 ? 149.235 96.841  90.714  1.00 124.14 ? 102 LYS A CG  1 
ATOM 516  C CD  . LYS A 1 102 ? 149.809 95.715  89.873  1.00 121.47 ? 102 LYS A CD  1 
ATOM 517  C CE  . LYS A 1 102 ? 148.956 95.462  88.642  1.00 119.51 ? 102 LYS A CE  1 
ATOM 518  N NZ  . LYS A 1 102 ? 147.503 95.497  88.959  1.00 119.97 ? 102 LYS A NZ  1 
ATOM 519  N N   . SER A 1 103 ? 148.568 98.807  94.343  1.00 116.42 ? 103 SER A N   1 
ATOM 520  C CA  . SER A 1 103 ? 147.342 99.149  95.046  1.00 117.81 ? 103 SER A CA  1 
ATOM 521  C C   . SER A 1 103 ? 147.611 100.301 96.003  1.00 120.14 ? 103 SER A C   1 
ATOM 522  O O   . SER A 1 103 ? 148.640 100.327 96.682  1.00 121.42 ? 103 SER A O   1 
ATOM 523  C CB  . SER A 1 103 ? 146.786 97.952  95.815  1.00 119.71 ? 103 SER A CB  1 
ATOM 524  O OG  . SER A 1 103 ? 145.579 98.295  96.472  1.00 125.16 ? 103 SER A OG  1 
ATOM 525  N N   . LEU A 1 104 ? 146.679 101.246 96.055  1.00 116.31 ? 104 LEU A N   1 
ATOM 526  C CA  . LEU A 1 104 ? 146.822 102.462 96.845  1.00 111.92 ? 104 LEU A CA  1 
ATOM 527  C C   . LEU A 1 104 ? 145.730 102.561 97.900  1.00 113.38 ? 104 LEU A C   1 
ATOM 528  O O   . LEU A 1 104 ? 145.186 103.636 98.158  1.00 119.92 ? 104 LEU A O   1 
ATOM 529  C CB  . LEU A 1 104 ? 146.814 103.695 95.948  1.00 109.37 ? 104 LEU A CB  1 
ATOM 530  C CG  . LEU A 1 104 ? 148.099 103.981 95.170  1.00 116.86 ? 104 LEU A CG  1 
ATOM 531  C CD1 . LEU A 1 104 ? 148.078 103.288 93.821  1.00 119.54 ? 104 LEU A CD1 1 
ATOM 532  C CD2 . LEU A 1 104 ? 148.294 105.474 95.000  1.00 120.90 ? 104 LEU A CD2 1 
ATOM 533  N N   . TRP A 1 105 ? 145.402 101.441 98.530  1.00 97.43  ? 105 TRP A N   1 
ATOM 534  C CA  . TRP A 1 105 ? 144.359 101.403 99.550  1.00 101.63 ? 105 TRP A CA  1 
ATOM 535  C C   . TRP A 1 105 ? 144.646 102.182 100.840 1.00 98.96  ? 105 TRP A C   1 
ATOM 536  O O   . TRP A 1 105 ? 143.679 102.568 101.507 1.00 106.16 ? 105 TRP A O   1 
ATOM 537  C CB  . TRP A 1 105 ? 144.018 99.948  99.893  1.00 106.82 ? 105 TRP A CB  1 
ATOM 538  C CG  . TRP A 1 105 ? 145.097 99.184  100.582 1.00 97.50  ? 105 TRP A CG  1 
ATOM 539  C CD1 . TRP A 1 105 ? 146.035 98.387  100.003 1.00 101.07 ? 105 TRP A CD1 1 
ATOM 540  C CD2 . TRP A 1 105 ? 145.335 99.125  101.992 1.00 94.26  ? 105 TRP A CD2 1 
ATOM 541  N NE1 . TRP A 1 105 ? 146.853 97.844  100.959 1.00 100.41 ? 105 TRP A NE1 1 
ATOM 542  C CE2 . TRP A 1 105 ? 146.444 98.283  102.190 1.00 103.92 ? 105 TRP A CE2 1 
ATOM 543  C CE3 . TRP A 1 105 ? 144.725 99.709  103.103 1.00 99.01  ? 105 TRP A CE3 1 
ATOM 544  C CZ2 . TRP A 1 105 ? 146.953 98.010  103.454 1.00 112.58 ? 105 TRP A CZ2 1 
ATOM 545  C CZ3 . TRP A 1 105 ? 145.232 99.436  104.357 1.00 107.81 ? 105 TRP A CZ3 1 
ATOM 546  C CH2 . TRP A 1 105 ? 146.334 98.594  104.522 1.00 108.21 ? 105 TRP A CH2 1 
ATOM 547  N N   . PRO A 1 106 ? 145.901 102.421 101.264 1.00 97.56  ? 106 PRO A N   1 
ATOM 548  C CA  . PRO A 1 106 ? 146.085 103.225 102.487 1.00 100.86 ? 106 PRO A CA  1 
ATOM 549  C C   . PRO A 1 106 ? 145.503 104.625 102.414 1.00 108.81 ? 106 PRO A C   1 
ATOM 550  O O   . PRO A 1 106 ? 145.160 105.188 103.459 1.00 112.23 ? 106 PRO A O   1 
ATOM 551  C CB  . PRO A 1 106 ? 147.607 103.266 102.650 1.00 103.86 ? 106 PRO A CB  1 
ATOM 552  C CG  . PRO A 1 106 ? 148.053 102.009 102.080 1.00 109.96 ? 106 PRO A CG  1 
ATOM 553  C CD  . PRO A 1 106 ? 147.185 101.795 100.882 1.00 106.14 ? 106 PRO A CD  1 
ATOM 554  N N   . HIS A 1 107 ? 145.394 105.211 101.219 1.00 114.43 ? 107 HIS A N   1 
ATOM 555  C CA  . HIS A 1 107 ? 144.846 106.560 101.108 1.00 109.76 ? 107 HIS A CA  1 
ATOM 556  C C   . HIS A 1 107 ? 143.395 106.607 101.564 1.00 112.22 ? 107 HIS A C   1 
ATOM 557  O O   . HIS A 1 107 ? 142.980 107.553 102.243 1.00 121.00 ? 107 HIS A O   1 
ATOM 558  C CB  . HIS A 1 107 ? 144.966 107.060 99.671  1.00 108.31 ? 107 HIS A CB  1 
ATOM 559  C CG  . HIS A 1 107 ? 146.334 107.537 99.310  1.00 113.18 ? 107 HIS A CG  1 
ATOM 560  N ND1 . HIS A 1 107 ? 147.188 106.811 98.509  1.00 120.00 ? 107 HIS A ND1 1 
ATOM 561  C CD2 . HIS A 1 107 ? 146.999 108.669 99.639  1.00 115.45 ? 107 HIS A CD2 1 
ATOM 562  C CE1 . HIS A 1 107 ? 148.320 107.476 98.360  1.00 117.97 ? 107 HIS A CE1 1 
ATOM 563  N NE2 . HIS A 1 107 ? 148.231 108.606 99.036  1.00 119.40 ? 107 HIS A NE2 1 
ATOM 564  N N   . LYS A 1 108 ? 142.606 105.597 101.196 1.00 119.88 ? 108 LYS A N   1 
ATOM 565  C CA  . LYS A 1 108 ? 141.199 105.584 101.578 1.00 121.32 ? 108 LYS A CA  1 
ATOM 566  C C   . LYS A 1 108 ? 141.029 105.310 103.068 1.00 120.30 ? 108 LYS A C   1 
ATOM 567  O O   . LYS A 1 108 ? 140.152 105.893 103.714 1.00 128.65 ? 108 LYS A O   1 
ATOM 568  C CB  . LYS A 1 108 ? 140.447 104.543 100.753 1.00 120.67 ? 108 LYS A CB  1 
ATOM 569  C CG  . LYS A 1 108 ? 138.970 104.426 101.086 1.00 120.52 ? 108 LYS A CG  1 
ATOM 570  C CD  . LYS A 1 108 ? 138.129 104.244 99.836  1.00 124.99 ? 108 LYS A CD  1 
ATOM 571  C CE  . LYS A 1 108 ? 138.696 103.163 98.930  1.00 132.15 ? 108 LYS A CE  1 
ATOM 572  N NZ  . LYS A 1 108 ? 138.824 101.853 99.628  1.00 129.64 ? 108 LYS A NZ  1 
ATOM 573  N N   . ALA A 1 109 ? 141.865 104.439 103.629 1.00 116.36 ? 109 ALA A N   1 
ATOM 574  C CA  . ALA A 1 109 ? 141.708 103.974 105.002 1.00 124.65 ? 109 ALA A CA  1 
ATOM 575  C C   . ALA A 1 109 ? 142.607 104.719 105.982 1.00 127.37 ? 109 ALA A C   1 
ATOM 576  O O   . ALA A 1 109 ? 143.054 104.137 106.973 1.00 130.61 ? 109 ALA A O   1 
ATOM 577  C CB  . ALA A 1 109 ? 141.973 102.473 105.081 1.00 129.23 ? 109 ALA A CB  1 
ATOM 578  N N   . LEU A 1 110 ? 142.885 105.998 105.726 1.00 123.18 ? 110 LEU A N   1 
ATOM 579  C CA  . LEU A 1 110 ? 143.716 106.755 106.661 1.00 122.83 ? 110 LEU A CA  1 
ATOM 580  C C   . LEU A 1 110 ? 142.968 107.146 107.932 1.00 123.88 ? 110 LEU A C   1 
ATOM 581  O O   . LEU A 1 110 ? 143.447 106.806 109.029 1.00 131.78 ? 110 LEU A O   1 
ATOM 582  C CB  . LEU A 1 110 ? 144.323 107.973 105.959 1.00 116.63 ? 110 LEU A CB  1 
ATOM 583  C CG  . LEU A 1 110 ? 145.501 108.626 106.678 1.00 113.92 ? 110 LEU A CG  1 
ATOM 584  C CD1 . LEU A 1 110 ? 146.544 107.588 107.040 1.00 116.56 ? 110 LEU A CD1 1 
ATOM 585  C CD2 . LEU A 1 110 ? 146.103 109.722 105.821 1.00 122.52 ? 110 LEU A CD2 1 
ATOM 586  N N   . PRO A 1 111 ? 141.832 107.858 107.882 1.00 125.26 ? 111 PRO A N   1 
ATOM 587  C CA  . PRO A 1 111 ? 141.215 108.300 109.142 1.00 130.49 ? 111 PRO A CA  1 
ATOM 588  C C   . PRO A 1 111 ? 140.715 107.162 110.011 1.00 132.65 ? 111 PRO A C   1 
ATOM 589  O O   . PRO A 1 111 ? 140.778 107.270 111.240 1.00 141.52 ? 111 PRO A O   1 
ATOM 590  C CB  . PRO A 1 111 ? 140.060 109.198 108.679 1.00 130.47 ? 111 PRO A CB  1 
ATOM 591  C CG  . PRO A 1 111 ? 140.320 109.473 107.240 1.00 130.37 ? 111 PRO A CG  1 
ATOM 592  C CD  . PRO A 1 111 ? 140.993 108.253 106.736 1.00 126.65 ? 111 PRO A CD  1 
ATOM 593  N N   . TYR A 1 112 ? 140.234 106.069 109.421 1.00 131.17 ? 112 TYR A N   1 
ATOM 594  C CA  . TYR A 1 112 ? 139.762 104.953 110.232 1.00 137.41 ? 112 TYR A CA  1 
ATOM 595  C C   . TYR A 1 112 ? 140.914 104.237 110.922 1.00 138.37 ? 112 TYR A C   1 
ATOM 596  O O   . TYR A 1 112 ? 140.806 103.874 112.101 1.00 143.58 ? 112 TYR A O   1 
ATOM 597  C CB  . TYR A 1 112 ? 138.957 103.988 109.365 1.00 141.89 ? 112 TYR A CB  1 
ATOM 598  C CG  . TYR A 1 112 ? 137.932 104.685 108.501 1.00 139.45 ? 112 TYR A CG  1 
ATOM 599  C CD1 . TYR A 1 112 ? 137.090 105.652 109.033 1.00 140.28 ? 112 TYR A CD1 1 
ATOM 600  C CD2 . TYR A 1 112 ? 137.817 104.389 107.151 1.00 139.38 ? 112 TYR A CD2 1 
ATOM 601  C CE1 . TYR A 1 112 ? 136.158 106.296 108.249 1.00 144.03 ? 112 TYR A CE1 1 
ATOM 602  C CE2 . TYR A 1 112 ? 136.885 105.030 106.359 1.00 141.52 ? 112 TYR A CE2 1 
ATOM 603  C CZ  . TYR A 1 112 ? 136.059 105.982 106.912 1.00 145.14 ? 112 TYR A CZ  1 
ATOM 604  O OH  . TYR A 1 112 ? 135.130 106.624 106.129 1.00 143.91 ? 112 TYR A OH  1 
ATOM 605  N N   . SER A 1 113 ? 142.026 104.038 110.216 1.00 127.18 ? 113 SER A N   1 
ATOM 606  C CA  . SER A 1 113 ? 143.219 103.487 110.841 1.00 133.01 ? 113 SER A CA  1 
ATOM 607  C C   . SER A 1 113 ? 143.786 104.402 111.916 1.00 133.41 ? 113 SER A C   1 
ATOM 608  O O   . SER A 1 113 ? 144.319 103.900 112.910 1.00 143.79 ? 113 SER A O   1 
ATOM 609  C CB  . SER A 1 113 ? 144.292 103.210 109.788 1.00 134.21 ? 113 SER A CB  1 
ATOM 610  O OG  . SER A 1 113 ? 145.587 103.375 110.334 1.00 141.94 ? 113 SER A OG  1 
ATOM 611  N N   . LEU A 1 114 ? 143.682 105.717 111.749 1.00 114.38 ? 114 LEU A N   1 
ATOM 612  C CA  . LEU A 1 114 ? 144.070 106.637 112.807 1.00 112.22 ? 114 LEU A CA  1 
ATOM 613  C C   . LEU A 1 114 ? 143.135 106.583 114.006 1.00 112.64 ? 114 LEU A C   1 
ATOM 614  O O   . LEU A 1 114 ? 143.604 106.668 115.144 1.00 124.23 ? 114 LEU A O   1 
ATOM 615  C CB  . LEU A 1 114 ? 144.126 108.070 112.273 1.00 113.56 ? 114 LEU A CB  1 
ATOM 616  C CG  . LEU A 1 114 ? 145.461 108.491 111.662 1.00 118.30 ? 114 LEU A CG  1 
ATOM 617  C CD1 . LEU A 1 114 ? 145.366 109.902 111.114 1.00 121.17 ? 114 LEU A CD1 1 
ATOM 618  C CD2 . LEU A 1 114 ? 146.574 108.386 112.687 1.00 119.15 ? 114 LEU A CD2 1 
ATOM 619  N N   . LEU A 1 115 ? 141.831 106.444 113.777 1.00 105.15 ? 115 LEU A N   1 
ATOM 620  C CA  . LEU A 1 115 ? 140.860 106.308 114.853 1.00 104.46 ? 115 LEU A CA  1 
ATOM 621  C C   . LEU A 1 115 ? 141.053 105.032 115.656 1.00 111.79 ? 115 LEU A C   1 
ATOM 622  O O   . LEU A 1 115 ? 140.862 105.046 116.876 1.00 124.82 ? 115 LEU A O   1 
ATOM 623  C CB  . LEU A 1 115 ? 139.440 106.344 114.288 1.00 111.90 ? 115 LEU A CB  1 
ATOM 624  C CG  . LEU A 1 115 ? 138.304 106.309 115.309 1.00 113.69 ? 115 LEU A CG  1 
ATOM 625  C CD1 . LEU A 1 115 ? 137.923 107.712 115.737 1.00 114.96 ? 115 LEU A CD1 1 
ATOM 626  C CD2 . LEU A 1 115 ? 137.102 105.578 114.740 1.00 119.07 ? 115 LEU A CD2 1 
ATOM 627  N N   . ALA A 1 116 ? 141.416 103.929 114.996 1.00 108.97 ? 116 ALA A N   1 
ATOM 628  C CA  . ALA A 1 116 ? 141.683 102.694 115.727 1.00 117.07 ? 116 ALA A CA  1 
ATOM 629  C C   . ALA A 1 116 ? 142.843 102.854 116.703 1.00 117.70 ? 116 ALA A C   1 
ATOM 630  O O   . ALA A 1 116 ? 142.836 102.251 117.786 1.00 123.74 ? 116 ALA A O   1 
ATOM 631  C CB  . ALA A 1 116 ? 141.966 101.554 114.752 1.00 119.20 ? 116 ALA A CB  1 
ATOM 632  N N   . LEU A 1 117 ? 143.840 103.663 116.339 1.00 106.99 ? 117 LEU A N   1 
ATOM 633  C CA  . LEU A 1 117 ? 144.967 103.908 117.231 1.00 102.47 ? 117 LEU A CA  1 
ATOM 634  C C   . LEU A 1 117 ? 144.530 104.585 118.520 1.00 106.24 ? 117 LEU A C   1 
ATOM 635  O O   . LEU A 1 117 ? 145.128 104.344 119.574 1.00 113.85 ? 117 LEU A O   1 
ATOM 636  C CB  . LEU A 1 117 ? 146.020 104.757 116.524 1.00 107.95 ? 117 LEU A CB  1 
ATOM 637  C CG  . LEU A 1 117 ? 147.475 104.512 116.921 1.00 106.61 ? 117 LEU A CG  1 
ATOM 638  C CD1 . LEU A 1 117 ? 147.710 103.049 117.243 1.00 105.00 ? 117 LEU A CD1 1 
ATOM 639  C CD2 . LEU A 1 117 ? 148.407 104.978 115.821 1.00 117.18 ? 117 LEU A CD2 1 
ATOM 640  N N   . ALA A 1 118 ? 143.498 105.429 118.464 1.00 121.43 ? 118 ALA A N   1 
ATOM 641  C CA  . ALA A 1 118 ? 143.004 106.070 119.677 1.00 123.56 ? 118 ALA A CA  1 
ATOM 642  C C   . ALA A 1 118 ? 142.471 105.043 120.667 1.00 132.21 ? 118 ALA A C   1 
ATOM 643  O O   . ALA A 1 118 ? 142.783 105.101 121.861 1.00 148.04 ? 118 ALA A O   1 
ATOM 644  C CB  . ALA A 1 118 ? 141.925 107.091 119.329 1.00 125.17 ? 118 ALA A CB  1 
ATOM 645  N N   . LEU A 1 119 ? 141.678 104.083 120.187 1.00 116.50 ? 119 LEU A N   1 
ATOM 646  C CA  . LEU A 1 119 ? 141.166 103.039 121.071 1.00 117.52 ? 119 LEU A CA  1 
ATOM 647  C C   . LEU A 1 119 ? 142.290 102.143 121.572 1.00 123.23 ? 119 LEU A C   1 
ATOM 648  O O   . LEU A 1 119 ? 142.289 101.723 122.739 1.00 137.65 ? 119 LEU A O   1 
ATOM 649  C CB  . LEU A 1 119 ? 140.102 102.213 120.350 1.00 119.69 ? 119 LEU A CB  1 
ATOM 650  C CG  . LEU A 1 119 ? 138.814 102.899 119.887 1.00 127.75 ? 119 LEU A CG  1 
ATOM 651  C CD1 . LEU A 1 119 ? 137.665 101.909 119.920 1.00 134.36 ? 119 LEU A CD1 1 
ATOM 652  C CD2 . LEU A 1 119 ? 138.476 104.117 120.736 1.00 128.13 ? 119 LEU A CD2 1 
ATOM 653  N N   . LEU A 1 120 ? 143.258 101.839 120.703 1.00 121.50 ? 120 LEU A N   1 
ATOM 654  C CA  . LEU A 1 120 ? 144.388 101.016 121.122 1.00 124.94 ? 120 LEU A CA  1 
ATOM 655  C C   . LEU A 1 120 ? 145.200 101.702 122.215 1.00 132.06 ? 120 LEU A C   1 
ATOM 656  O O   . LEU A 1 120 ? 145.697 101.042 123.135 1.00 137.28 ? 120 LEU A O   1 
ATOM 657  C CB  . LEU A 1 120 ? 145.271 100.677 119.922 1.00 131.73 ? 120 LEU A CB  1 
ATOM 658  C CG  . LEU A 1 120 ? 144.975 99.407  119.115 1.00 135.52 ? 120 LEU A CG  1 
ATOM 659  C CD1 . LEU A 1 120 ? 145.482 98.191  119.861 1.00 130.15 ? 120 LEU A CD1 1 
ATOM 660  C CD2 . LEU A 1 120 ? 143.498 99.241  118.801 1.00 138.09 ? 120 LEU A CD2 1 
ATOM 661  N N   . MET A 1 121 ? 145.349 103.026 122.133 1.00 128.19 ? 121 MET A N   1 
ATOM 662  C CA  . MET A 1 121 ? 146.030 103.759 123.196 1.00 123.56 ? 121 MET A CA  1 
ATOM 663  C C   . MET A 1 121 ? 145.181 103.859 124.453 1.00 126.19 ? 121 MET A C   1 
ATOM 664  O O   . MET A 1 121 ? 145.719 103.850 125.564 1.00 136.07 ? 121 MET A O   1 
ATOM 665  C CB  . MET A 1 121 ? 146.411 105.161 122.719 1.00 130.66 ? 121 MET A CB  1 
ATOM 666  C CG  . MET A 1 121 ? 147.508 105.301 121.642 1.00 138.34 ? 121 MET A CG  1 
ATOM 667  S SD  . MET A 1 121 ? 149.056 104.359 121.725 1.00 144.98 ? 121 MET A SD  1 
ATOM 668  C CE  . MET A 1 121 ? 148.590 102.732 121.146 1.00 131.15 ? 121 MET A CE  1 
ATOM 669  N N   . TYR A 1 122 ? 143.862 103.976 124.304 1.00 137.00 ? 122 TYR A N   1 
ATOM 670  C CA  . TYR A 1 122 ? 142.992 104.141 125.460 1.00 140.41 ? 122 TYR A CA  1 
ATOM 671  C C   . TYR A 1 122 ? 142.797 102.853 126.245 1.00 144.43 ? 122 TYR A C   1 
ATOM 672  O O   . TYR A 1 122 ? 142.434 102.916 127.424 1.00 152.65 ? 122 TYR A O   1 
ATOM 673  C CB  . TYR A 1 122 ? 141.630 104.674 125.019 1.00 142.61 ? 122 TYR A CB  1 
ATOM 674  C CG  . TYR A 1 122 ? 140.837 105.317 126.131 1.00 142.88 ? 122 TYR A CG  1 
ATOM 675  C CD1 . TYR A 1 122 ? 141.470 105.853 127.242 1.00 146.45 ? 122 TYR A CD1 1 
ATOM 676  C CD2 . TYR A 1 122 ? 139.453 105.385 126.069 1.00 143.75 ? 122 TYR A CD2 1 
ATOM 677  C CE1 . TYR A 1 122 ? 140.749 106.441 128.259 1.00 149.23 ? 122 TYR A CE1 1 
ATOM 678  C CE2 . TYR A 1 122 ? 138.725 105.971 127.081 1.00 151.31 ? 122 TYR A CE2 1 
ATOM 679  C CZ  . TYR A 1 122 ? 139.376 106.498 128.173 1.00 153.85 ? 122 TYR A CZ  1 
ATOM 680  O OH  . TYR A 1 122 ? 138.652 107.082 129.185 1.00 157.35 ? 122 TYR A OH  1 
ATOM 681  N N   . LEU A 1 123 ? 143.006 101.695 125.618 1.00 126.90 ? 123 LEU A N   1 
ATOM 682  C CA  . LEU A 1 123 ? 142.781 100.430 126.321 1.00 125.26 ? 123 LEU A CA  1 
ATOM 683  C C   . LEU A 1 123 ? 143.648 100.256 127.570 1.00 130.65 ? 123 LEU A C   1 
ATOM 684  O O   . LEU A 1 123 ? 143.099 99.864  128.615 1.00 141.91 ? 123 LEU A O   1 
ATOM 685  C CB  . LEU A 1 123 ? 142.950 99.269  125.332 1.00 129.05 ? 123 LEU A CB  1 
ATOM 686  C CG  . LEU A 1 123 ? 142.615 97.847  125.787 1.00 134.78 ? 123 LEU A CG  1 
ATOM 687  C CD1 . LEU A 1 123 ? 142.011 97.072  124.632 1.00 139.74 ? 123 LEU A CD1 1 
ATOM 688  C CD2 . LEU A 1 123 ? 143.848 97.125  126.304 1.00 136.63 ? 123 LEU A CD2 1 
ATOM 689  N N   . PRO A 1 124 ? 144.969 100.497 127.551 1.00 122.67 ? 124 PRO A N   1 
ATOM 690  C CA  . PRO A 1 124 ? 145.740 100.359 128.802 1.00 123.43 ? 124 PRO A CA  1 
ATOM 691  C C   . PRO A 1 124 ? 145.295 101.297 129.908 1.00 118.70 ? 124 PRO A C   1 
ATOM 692  O O   . PRO A 1 124 ? 145.372 100.930 131.089 1.00 125.04 ? 124 PRO A O   1 
ATOM 693  C CB  . PRO A 1 124 ? 147.178 100.657 128.359 1.00 125.86 ? 124 PRO A CB  1 
ATOM 694  C CG  . PRO A 1 124 ? 147.199 100.298 126.933 1.00 125.35 ? 124 PRO A CG  1 
ATOM 695  C CD  . PRO A 1 124 ? 145.874 100.752 126.414 1.00 128.15 ? 124 PRO A CD  1 
ATOM 696  N N   . VAL A 1 125 ? 144.837 102.502 129.565 1.00 115.74 ? 125 VAL A N   1 
ATOM 697  C CA  . VAL A 1 125 ? 144.320 103.414 130.578 1.00 119.69 ? 125 VAL A CA  1 
ATOM 698  C C   . VAL A 1 125 ? 143.093 102.812 131.248 1.00 122.43 ? 125 VAL A C   1 
ATOM 699  O O   . VAL A 1 125 ? 142.948 102.867 132.475 1.00 128.75 ? 125 VAL A O   1 
ATOM 700  C CB  . VAL A 1 125 ? 144.014 104.786 129.952 1.00 125.75 ? 125 VAL A CB  1 
ATOM 701  C CG1 . VAL A 1 125 ? 143.119 105.606 130.862 1.00 127.48 ? 125 VAL A CG1 1 
ATOM 702  C CG2 . VAL A 1 125 ? 145.305 105.526 129.661 1.00 127.80 ? 125 VAL A CG2 1 
ATOM 703  N N   . LEU A 1 126 ? 142.202 102.213 130.456 1.00 127.42 ? 126 LEU A N   1 
ATOM 704  C CA  . LEU A 1 126 ? 141.037 101.542 131.021 1.00 126.63 ? 126 LEU A CA  1 
ATOM 705  C C   . LEU A 1 126 ? 141.449 100.376 131.907 1.00 133.59 ? 126 LEU A C   1 
ATOM 706  O O   . LEU A 1 126 ? 140.848 100.149 132.965 1.00 145.24 ? 126 LEU A O   1 
ATOM 707  C CB  . LEU A 1 126 ? 140.116 101.060 129.905 1.00 129.13 ? 126 LEU A CB  1 
ATOM 708  C CG  . LEU A 1 126 ? 138.770 101.772 129.793 1.00 134.54 ? 126 LEU A CG  1 
ATOM 709  C CD1 . LEU A 1 126 ? 138.978 103.252 129.541 1.00 133.68 ? 126 LEU A CD1 1 
ATOM 710  C CD2 . LEU A 1 126 ? 137.934 101.150 128.691 1.00 139.87 ? 126 LEU A CD2 1 
ATOM 711  N N   . LEU A 1 127 ? 142.463 99.617  131.486 1.00 107.15 ? 127 LEU A N   1 
ATOM 712  C CA  . LEU A 1 127 ? 142.932 98.495  132.294 1.00 98.58  ? 127 LEU A CA  1 
ATOM 713  C C   . LEU A 1 127 ? 143.443 98.968  133.648 1.00 106.86 ? 127 LEU A C   1 
ATOM 714  O O   . LEU A 1 127 ? 143.091 98.405  134.692 1.00 115.81 ? 127 LEU A O   1 
ATOM 715  C CB  . LEU A 1 127 ? 144.026 97.734  131.550 1.00 99.28  ? 127 LEU A CB  1 
ATOM 716  C CG  . LEU A 1 127 ? 144.863 96.807  132.427 1.00 100.02 ? 127 LEU A CG  1 
ATOM 717  C CD1 . LEU A 1 127 ? 144.124 95.509  132.681 1.00 110.17 ? 127 LEU A CD1 1 
ATOM 718  C CD2 . LEU A 1 127 ? 146.208 96.547  131.787 1.00 108.61 ? 127 LEU A CD2 1 
ATOM 719  N N   . TRP A 1 128 ? 144.270 100.015 133.649 1.00 123.74 ? 128 TRP A N   1 
ATOM 720  C CA  . TRP A 1 128 ? 144.772 100.554 134.909 1.00 118.87 ? 128 TRP A CA  1 
ATOM 721  C C   . TRP A 1 128 ? 143.651 101.135 135.758 1.00 115.38 ? 128 TRP A C   1 
ATOM 722  O O   . TRP A 1 128 ? 143.691 101.033 136.988 1.00 118.85 ? 128 TRP A O   1 
ATOM 723  C CB  . TRP A 1 128 ? 145.834 101.618 134.646 1.00 127.33 ? 128 TRP A CB  1 
ATOM 724  C CG  . TRP A 1 128 ? 146.303 102.309 135.884 1.00 120.94 ? 128 TRP A CG  1 
ATOM 725  C CD1 . TRP A 1 128 ? 145.881 103.512 136.362 1.00 122.33 ? 128 TRP A CD1 1 
ATOM 726  C CD2 . TRP A 1 128 ? 147.291 101.835 136.806 1.00 114.04 ? 128 TRP A CD2 1 
ATOM 727  N NE1 . TRP A 1 128 ? 146.543 103.818 137.525 1.00 115.08 ? 128 TRP A NE1 1 
ATOM 728  C CE2 . TRP A 1 128 ? 147.414 102.804 137.818 1.00 111.12 ? 128 TRP A CE2 1 
ATOM 729  C CE3 . TRP A 1 128 ? 148.082 100.687 136.870 1.00 116.13 ? 128 TRP A CE3 1 
ATOM 730  C CZ2 . TRP A 1 128 ? 148.295 102.658 138.882 1.00 115.23 ? 128 TRP A CZ2 1 
ATOM 731  C CZ3 . TRP A 1 128 ? 148.956 100.545 137.928 1.00 112.86 ? 128 TRP A CZ3 1 
ATOM 732  C CH2 . TRP A 1 128 ? 149.056 101.525 138.919 1.00 114.46 ? 128 TRP A CH2 1 
ATOM 733  N N   . GLN A 1 129 ? 142.653 101.749 135.124 1.00 119.27 ? 129 GLN A N   1 
ATOM 734  C CA  . GLN A 1 129 ? 141.558 102.353 135.872 1.00 115.60 ? 129 GLN A CA  1 
ATOM 735  C C   . GLN A 1 129 ? 140.679 101.299 136.531 1.00 121.44 ? 129 GLN A C   1 
ATOM 736  O O   . GLN A 1 129 ? 140.182 101.507 137.641 1.00 129.74 ? 129 GLN A O   1 
ATOM 737  C CB  . GLN A 1 129 ? 140.721 103.235 134.946 1.00 124.82 ? 129 GLN A CB  1 
ATOM 738  C CG  . GLN A 1 129 ? 139.925 104.311 135.658 1.00 126.76 ? 129 GLN A CG  1 
ATOM 739  C CD  . GLN A 1 129 ? 140.736 105.565 135.920 1.00 138.43 ? 129 GLN A CD  1 
ATOM 740  O OE1 . GLN A 1 129 ? 141.967 105.538 135.919 1.00 138.94 ? 129 GLN A OE1 1 
ATOM 741  N NE2 . GLN A 1 129 ? 140.045 106.676 136.144 1.00 143.00 ? 129 GLN A NE2 1 
ATOM 742  N N   . TYR A 1 130 ? 140.449 100.176 135.859 1.00 130.27 ? 130 TYR A N   1 
ATOM 743  C CA  . TYR A 1 130 ? 139.498 99.189  136.349 1.00 127.91 ? 130 TYR A CA  1 
ATOM 744  C C   . TYR A 1 130 ? 140.151 97.943  136.927 1.00 126.90 ? 130 TYR A C   1 
ATOM 745  O O   . TYR A 1 130 ? 139.438 96.984  137.238 1.00 130.88 ? 130 TYR A O   1 
ATOM 746  C CB  . TYR A 1 130 ? 138.528 98.785  135.234 1.00 136.36 ? 130 TYR A CB  1 
ATOM 747  C CG  . TYR A 1 130 ? 137.425 99.785  134.954 1.00 136.69 ? 130 TYR A CG  1 
ATOM 748  C CD1 . TYR A 1 130 ? 136.235 99.380  134.367 1.00 139.77 ? 130 TYR A CD1 1 
ATOM 749  C CD2 . TYR A 1 130 ? 137.565 101.126 135.283 1.00 135.54 ? 130 TYR A CD2 1 
ATOM 750  C CE1 . TYR A 1 130 ? 135.224 100.281 134.110 1.00 142.55 ? 130 TYR A CE1 1 
ATOM 751  C CE2 . TYR A 1 130 ? 136.561 102.034 135.029 1.00 138.02 ? 130 TYR A CE2 1 
ATOM 752  C CZ  . TYR A 1 130 ? 135.392 101.606 134.443 1.00 144.19 ? 130 TYR A CZ  1 
ATOM 753  O OH  . TYR A 1 130 ? 134.386 102.510 134.189 1.00 148.95 ? 130 TYR A OH  1 
ATOM 754  N N   . ALA A 1 131 ? 141.472 97.917  137.082 1.00 141.59 ? 131 ALA A N   1 
ATOM 755  C CA  . ALA A 1 131 ? 142.132 96.728  137.606 1.00 147.38 ? 131 ALA A CA  1 
ATOM 756  C C   . ALA A 1 131 ? 143.147 96.983  138.706 1.00 148.07 ? 131 ALA A C   1 
ATOM 757  O O   . ALA A 1 131 ? 143.530 96.023  139.388 1.00 146.06 ? 131 ALA A O   1 
ATOM 758  C CB  . ALA A 1 131 ? 142.828 95.962  136.472 1.00 153.20 ? 131 ALA A CB  1 
ATOM 759  N N   . ALA A 1 132 ? 143.604 98.216  138.913 1.00 154.03 ? 132 ALA A N   1 
ATOM 760  C CA  . ALA A 1 132 ? 144.680 98.438  139.870 1.00 150.71 ? 132 ALA A CA  1 
ATOM 761  C C   . ALA A 1 132 ? 144.338 99.494  140.910 1.00 146.16 ? 132 ALA A C   1 
ATOM 762  O O   . ALA A 1 132 ? 144.717 99.361  142.078 1.00 149.01 ? 132 ALA A O   1 
ATOM 763  C CB  . ALA A 1 132 ? 145.965 98.830  139.138 1.00 152.40 ? 132 ALA A CB  1 
ATOM 764  N N   . VAL A 1 133 ? 143.630 100.544 140.509 1.00 127.10 ? 133 VAL A N   1 
ATOM 765  C CA  . VAL A 1 133 ? 143.405 101.678 141.403 1.00 126.50 ? 133 VAL A CA  1 
ATOM 766  C C   . VAL A 1 133 ? 142.485 101.365 142.587 1.00 133.14 ? 133 VAL A C   1 
ATOM 767  O O   . VAL A 1 133 ? 142.682 101.980 143.644 1.00 140.86 ? 133 VAL A O   1 
ATOM 768  C CB  . VAL A 1 133 ? 142.905 102.907 140.617 1.00 130.09 ? 133 VAL A CB  1 
ATOM 769  C CG1 . VAL A 1 133 ? 141.457 102.784 140.207 1.00 129.02 ? 133 VAL A CG1 1 
ATOM 770  C CG2 . VAL A 1 133 ? 143.137 104.181 141.405 1.00 140.70 ? 133 VAL A CG2 1 
ATOM 771  N N   . PRO A 1 134 ? 141.497 100.445 142.523 1.00 136.06 ? 134 PRO A N   1 
ATOM 772  C CA  . PRO A 1 134 ? 140.677 100.242 143.733 1.00 139.73 ? 134 PRO A CA  1 
ATOM 773  C C   . PRO A 1 134 ? 141.448 99.654  144.899 1.00 142.95 ? 134 PRO A C   1 
ATOM 774  O O   . PRO A 1 134 ? 141.314 100.138 146.029 1.00 147.50 ? 134 PRO A O   1 
ATOM 775  C CB  . PRO A 1 134 ? 139.570 99.294  143.249 1.00 143.72 ? 134 PRO A CB  1 
ATOM 776  C CG  . PRO A 1 134 ? 139.530 99.484  141.794 1.00 141.79 ? 134 PRO A CG  1 
ATOM 777  C CD  . PRO A 1 134 ? 140.964 99.602  141.435 1.00 137.65 ? 134 PRO A CD  1 
ATOM 778  N N   . ALA A 1 135 ? 142.252 98.614  144.661 1.00 138.12 ? 135 ALA A N   1 
ATOM 779  C CA  . ALA A 1 135 ? 143.046 98.038  145.740 1.00 142.37 ? 135 ALA A CA  1 
ATOM 780  C C   . ALA A 1 135 ? 144.102 99.017  146.235 1.00 142.81 ? 135 ALA A C   1 
ATOM 781  O O   . ALA A 1 135 ? 144.298 99.171  147.449 1.00 146.46 ? 135 ALA A O   1 
ATOM 782  C CB  . ALA A 1 135 ? 143.697 96.737  145.276 1.00 138.37 ? 135 ALA A CB  1 
ATOM 783  N N   . LEU A 1 136 ? 144.784 99.696  145.310 1.00 139.87 ? 136 LEU A N   1 
ATOM 784  C CA  . LEU A 1 136 ? 145.872 100.582 145.697 1.00 140.44 ? 136 LEU A CA  1 
ATOM 785  C C   . LEU A 1 136 ? 145.360 101.807 146.440 1.00 143.10 ? 136 LEU A C   1 
ATOM 786  O O   . LEU A 1 136 ? 146.058 102.334 147.309 1.00 146.18 ? 136 LEU A O   1 
ATOM 787  C CB  . LEU A 1 136 ? 146.678 100.988 144.463 1.00 139.15 ? 136 LEU A CB  1 
ATOM 788  C CG  . LEU A 1 136 ? 147.804 102.005 144.648 1.00 143.48 ? 136 LEU A CG  1 
ATOM 789  C CD1 . LEU A 1 136 ? 149.060 101.532 143.949 1.00 145.06 ? 136 LEU A CD1 1 
ATOM 790  C CD2 . LEU A 1 136 ? 147.396 103.363 144.123 1.00 144.99 ? 136 LEU A CD2 1 
ATOM 791  N N   . SER A 1 137 ? 144.145 102.264 146.131 1.00 137.88 ? 137 SER A N   1 
ATOM 792  C CA  . SER A 1 137 ? 143.573 103.394 146.856 1.00 139.33 ? 137 SER A CA  1 
ATOM 793  C C   . SER A 1 137 ? 143.402 103.069 148.334 1.00 141.51 ? 137 SER A C   1 
ATOM 794  O O   . SER A 1 137 ? 143.807 103.847 149.208 1.00 147.69 ? 137 SER A O   1 
ATOM 795  C CB  . SER A 1 137 ? 142.235 103.788 146.232 1.00 138.99 ? 137 SER A CB  1 
ATOM 796  O OG  . SER A 1 137 ? 141.697 104.934 146.863 1.00 144.87 ? 137 SER A OG  1 
ATOM 797  N N   . SER A 1 138 ? 142.805 101.912 148.632 1.00 144.72 ? 138 SER A N   1 
ATOM 798  C CA  . SER A 1 138 ? 142.652 101.495 150.021 1.00 149.30 ? 138 SER A CA  1 
ATOM 799  C C   . SER A 1 138 ? 144.004 101.248 150.675 1.00 147.49 ? 138 SER A C   1 
ATOM 800  O O   . SER A 1 138 ? 144.220 101.622 151.836 1.00 154.37 ? 138 SER A O   1 
ATOM 801  C CB  . SER A 1 138 ? 141.784 100.241 150.099 1.00 148.85 ? 138 SER A CB  1 
ATOM 802  O OG  . SER A 1 138 ? 140.563 100.426 149.407 1.00 155.90 ? 138 SER A OG  1 
ATOM 803  N N   . ASP A 1 139 ? 144.927 100.617 149.942 1.00 144.64 ? 139 ASP A N   1 
ATOM 804  C CA  . ASP A 1 139 ? 146.246 100.339 150.490 1.00 148.41 ? 139 ASP A CA  1 
ATOM 805  C C   . ASP A 1 139 ? 147.025 101.610 150.794 1.00 148.88 ? 139 ASP A C   1 
ATOM 806  O O   . ASP A 1 139 ? 147.863 101.607 151.698 1.00 151.88 ? 139 ASP A O   1 
ATOM 807  C CB  . ASP A 1 139 ? 147.034 99.463  149.522 1.00 156.78 ? 139 ASP A CB  1 
ATOM 808  C CG  . ASP A 1 139 ? 146.847 97.989  149.794 1.00 161.87 ? 139 ASP A CG  1 
ATOM 809  O OD1 . ASP A 1 139 ? 145.876 97.634  150.494 1.00 163.05 ? 139 ASP A OD1 1 
ATOM 810  O OD2 . ASP A 1 139 ? 147.670 97.183  149.310 1.00 162.61 ? 139 ASP A OD2 1 
ATOM 811  N N   . LEU A 1 140 ? 146.764 102.691 150.060 1.00 141.21 ? 140 LEU A N   1 
ATOM 812  C CA  . LEU A 1 140 ? 147.414 103.961 150.351 1.00 142.25 ? 140 LEU A CA  1 
ATOM 813  C C   . LEU A 1 140 ? 146.729 104.685 151.499 1.00 144.33 ? 140 LEU A C   1 
ATOM 814  O O   . LEU A 1 140 ? 147.404 105.274 152.350 1.00 143.91 ? 140 LEU A O   1 
ATOM 815  C CB  . LEU A 1 140 ? 147.426 104.843 149.104 1.00 139.56 ? 140 LEU A CB  1 
ATOM 816  C CG  . LEU A 1 140 ? 148.638 104.712 148.184 1.00 140.06 ? 140 LEU A CG  1 
ATOM 817  C CD1 . LEU A 1 140 ? 148.725 105.910 147.256 1.00 144.87 ? 140 LEU A CD1 1 
ATOM 818  C CD2 . LEU A 1 140 ? 149.916 104.557 148.988 1.00 140.00 ? 140 LEU A CD2 1 
ATOM 819  N N   . LEU A 1 141 ? 145.395 104.657 151.540 1.00 148.67 ? 141 LEU A N   1 
ATOM 820  C CA  . LEU A 1 141 ? 144.675 105.330 152.617 1.00 144.60 ? 141 LEU A CA  1 
ATOM 821  C C   . LEU A 1 141 ? 145.029 104.730 153.970 1.00 139.98 ? 141 LEU A C   1 
ATOM 822  O O   . LEU A 1 141 ? 145.298 105.457 154.937 1.00 147.85 ? 141 LEU A O   1 
ATOM 823  C CB  . LEU A 1 141 ? 143.170 105.247 152.373 1.00 146.36 ? 141 LEU A CB  1 
ATOM 824  C CG  . LEU A 1 141 ? 142.597 106.216 151.342 1.00 149.32 ? 141 LEU A CG  1 
ATOM 825  C CD1 . LEU A 1 141 ? 141.164 105.849 151.009 1.00 150.86 ? 141 LEU A CD1 1 
ATOM 826  C CD2 . LEU A 1 141 ? 142.681 107.642 151.855 1.00 148.87 ? 141 LEU A CD2 1 
ATOM 827  N N   . PHE A 1 142 ? 145.051 103.398 154.051 1.00 127.69 ? 142 PHE A N   1 
ATOM 828  C CA  . PHE A 1 142 ? 145.354 102.737 155.317 1.00 135.94 ? 142 PHE A CA  1 
ATOM 829  C C   . PHE A 1 142 ? 146.770 103.050 155.783 1.00 139.87 ? 142 PHE A C   1 
ATOM 830  O O   . PHE A 1 142 ? 146.990 103.379 156.958 1.00 145.22 ? 142 PHE A O   1 
ATOM 831  C CB  . PHE A 1 142 ? 145.150 101.230 155.166 1.00 134.65 ? 142 PHE A CB  1 
ATOM 832  C CG  . PHE A 1 142 ? 145.839 100.414 156.214 1.00 131.37 ? 142 PHE A CG  1 
ATOM 833  C CD1 . PHE A 1 142 ? 145.432 100.469 157.534 1.00 134.56 ? 142 PHE A CD1 1 
ATOM 834  C CD2 . PHE A 1 142 ? 146.890 99.582  155.876 1.00 131.97 ? 142 PHE A CD2 1 
ATOM 835  C CE1 . PHE A 1 142 ? 146.064 99.714  158.497 1.00 136.87 ? 142 PHE A CE1 1 
ATOM 836  C CE2 . PHE A 1 142 ? 147.526 98.826  156.836 1.00 136.12 ? 142 PHE A CE2 1 
ATOM 837  C CZ  . PHE A 1 142 ? 147.111 98.889  158.144 1.00 137.17 ? 142 PHE A CZ  1 
ATOM 838  N N   . ILE A 1 143 ? 147.744 102.967 154.872 1.00 130.77 ? 143 ILE A N   1 
ATOM 839  C CA  . ILE A 1 143 ? 149.129 103.201 155.259 1.00 129.78 ? 143 ILE A CA  1 
ATOM 840  C C   . ILE A 1 143 ? 149.343 104.664 155.626 1.00 129.81 ? 143 ILE A C   1 
ATOM 841  O O   . ILE A 1 143 ? 150.101 104.973 156.549 1.00 133.71 ? 143 ILE A O   1 
ATOM 842  C CB  . ILE A 1 143 ? 150.099 102.722 154.159 1.00 128.09 ? 143 ILE A CB  1 
ATOM 843  C CG1 . ILE A 1 143 ? 151.524 102.654 154.702 1.00 126.66 ? 143 ILE A CG1 1 
ATOM 844  C CG2 . ILE A 1 143 ? 150.067 103.615 152.936 1.00 133.56 ? 143 ILE A CG2 1 
ATOM 845  C CD1 . ILE A 1 143 ? 151.882 101.308 155.269 1.00 133.13 ? 143 ILE A CD1 1 
ATOM 846  N N   . ILE A 1 144 ? 148.655 105.586 154.945 1.00 130.87 ? 144 ILE A N   1 
ATOM 847  C CA  . ILE A 1 144 ? 148.783 107.002 155.277 1.00 133.49 ? 144 ILE A CA  1 
ATOM 848  C C   . ILE A 1 144 ? 148.228 107.273 156.668 1.00 136.45 ? 144 ILE A C   1 
ATOM 849  O O   . ILE A 1 144 ? 148.862 107.951 157.487 1.00 137.22 ? 144 ILE A O   1 
ATOM 850  C CB  . ILE A 1 144 ? 148.085 107.862 154.207 1.00 136.55 ? 144 ILE A CB  1 
ATOM 851  C CG1 . ILE A 1 144 ? 149.029 108.113 153.034 1.00 137.20 ? 144 ILE A CG1 1 
ATOM 852  C CG2 . ILE A 1 144 ? 147.623 109.189 154.787 1.00 137.19 ? 144 ILE A CG2 1 
ATOM 853  C CD1 . ILE A 1 144 ? 150.320 108.779 153.441 1.00 139.88 ? 144 ILE A CD1 1 
ATOM 854  N N   . SER A 1 145 ? 147.040 106.733 156.961 1.00 158.97 ? 145 SER A N   1 
ATOM 855  C CA  . SER A 1 145 ? 146.433 106.965 158.266 1.00 161.12 ? 145 SER A CA  1 
ATOM 856  C C   . SER A 1 145 ? 147.290 106.386 159.385 1.00 161.23 ? 145 SER A C   1 
ATOM 857  O O   . SER A 1 145 ? 147.525 107.048 160.405 1.00 165.16 ? 145 SER A O   1 
ATOM 858  C CB  . SER A 1 145 ? 145.027 106.370 158.306 1.00 163.91 ? 145 SER A CB  1 
ATOM 859  O OG  . SER A 1 145 ? 145.027 105.118 158.969 1.00 168.53 ? 145 SER A OG  1 
ATOM 860  N N   . GLU A 1 146 ? 147.794 105.165 159.205 1.00 154.94 ? 146 GLU A N   1 
ATOM 861  C CA  . GLU A 1 146 ? 148.571 104.576 160.287 1.00 156.28 ? 146 GLU A CA  1 
ATOM 862  C C   . GLU A 1 146 ? 149.962 105.199 160.389 1.00 157.44 ? 146 GLU A C   1 
ATOM 863  O O   . GLU A 1 146 ? 150.518 105.274 161.490 1.00 162.75 ? 146 GLU A O   1 
ATOM 864  C CB  . GLU A 1 146 ? 148.628 103.055 160.121 1.00 157.34 ? 146 GLU A CB  1 
ATOM 865  C CG  . GLU A 1 146 ? 149.934 102.387 160.490 1.00 161.46 ? 146 GLU A CG  1 
ATOM 866  C CD  . GLU A 1 146 ? 149.831 100.881 160.408 1.00 168.12 ? 146 GLU A CD  1 
ATOM 867  O OE1 . GLU A 1 146 ? 148.694 100.372 160.348 1.00 169.65 ? 146 GLU A OE1 1 
ATOM 868  O OE2 . GLU A 1 146 ? 150.874 100.204 160.425 1.00 167.72 ? 146 GLU A OE2 1 
ATOM 869  N N   . LEU A 1 147 ? 150.514 105.705 159.283 1.00 149.56 ? 147 LEU A N   1 
ATOM 870  C CA  . LEU A 1 147 ? 151.758 106.461 159.361 1.00 149.32 ? 147 LEU A CA  1 
ATOM 871  C C   . LEU A 1 147 ? 151.568 107.744 160.158 1.00 153.14 ? 147 LEU A C   1 
ATOM 872  O O   . LEU A 1 147 ? 152.417 108.106 160.985 1.00 157.68 ? 147 LEU A O   1 
ATOM 873  C CB  . LEU A 1 147 ? 152.264 106.780 157.956 1.00 151.11 ? 147 LEU A CB  1 
ATOM 874  C CG  . LEU A 1 147 ? 153.766 106.637 157.711 1.00 156.26 ? 147 LEU A CG  1 
ATOM 875  C CD1 . LEU A 1 147 ? 154.342 105.507 158.544 1.00 154.33 ? 147 LEU A CD1 1 
ATOM 876  C CD2 . LEU A 1 147 ? 154.036 106.410 156.236 1.00 158.61 ? 147 LEU A CD2 1 
ATOM 877  N N   . ASP A 1 148 ? 150.453 108.439 159.924 1.00 173.02 ? 148 ASP A N   1 
ATOM 878  C CA  . ASP A 1 148 ? 150.156 109.649 160.684 1.00 176.88 ? 148 ASP A CA  1 
ATOM 879  C C   . ASP A 1 148 ? 149.994 109.312 162.164 1.00 177.87 ? 148 ASP A C   1 
ATOM 880  O O   . ASP A 1 148 ? 150.510 110.026 163.033 1.00 177.67 ? 148 ASP A O   1 
ATOM 881  C CB  . ASP A 1 148 ? 148.902 110.310 160.084 1.00 180.32 ? 148 ASP A CB  1 
ATOM 882  C CG  . ASP A 1 148 ? 148.369 111.519 160.877 1.00 182.92 ? 148 ASP A CG  1 
ATOM 883  O OD1 . ASP A 1 148 ? 147.794 112.402 160.208 1.00 183.55 ? 148 ASP A OD1 1 
ATOM 884  O OD2 . ASP A 1 148 ? 148.466 111.614 162.118 1.00 185.10 ? 148 ASP A OD2 1 
ATOM 885  N N   . LYS A 1 149 ? 149.306 108.206 162.461 1.00 161.46 ? 149 LYS A N   1 
ATOM 886  C CA  . LYS A 1 149 ? 149.133 107.791 163.852 1.00 158.74 ? 149 LYS A CA  1 
ATOM 887  C C   . LYS A 1 149 ? 150.471 107.481 164.515 1.00 158.59 ? 149 LYS A C   1 
ATOM 888  O O   . LYS A 1 149 ? 150.704 107.859 165.670 1.00 158.89 ? 149 LYS A O   1 
ATOM 889  C CB  . LYS A 1 149 ? 148.209 106.577 163.919 1.00 160.19 ? 149 LYS A CB  1 
ATOM 890  C CG  . LYS A 1 149 ? 148.257 105.838 165.245 1.00 162.89 ? 149 LYS A CG  1 
ATOM 891  C CD  . LYS A 1 149 ? 148.027 104.350 165.052 1.00 162.64 ? 149 LYS A CD  1 
ATOM 892  C CE  . LYS A 1 149 ? 148.519 103.554 166.251 1.00 162.76 ? 149 LYS A CE  1 
ATOM 893  N NZ  . LYS A 1 149 ? 148.149 102.113 166.157 1.00 162.86 ? 149 LYS A NZ  1 
ATOM 894  N N   . SER A 1 150 ? 151.363 106.793 163.799 1.00 175.36 ? 150 SER A N   1 
ATOM 895  C CA  . SER A 1 150 ? 152.672 106.468 164.359 1.00 174.62 ? 150 SER A CA  1 
ATOM 896  C C   . SER A 1 150 ? 153.499 107.723 164.606 1.00 173.72 ? 150 SER A C   1 
ATOM 897  O O   . SER A 1 150 ? 154.209 107.814 165.615 1.00 171.48 ? 150 SER A O   1 
ATOM 898  C CB  . SER A 1 150 ? 153.418 105.511 163.434 1.00 176.52 ? 150 SER A CB  1 
ATOM 899  O OG  . SER A 1 150 ? 153.114 105.771 162.081 1.00 177.24 ? 150 SER A OG  1 
ATOM 900  N N   . TYR A 1 151 ? 153.435 108.690 163.687 1.00 184.83 ? 151 TYR A N   1 
ATOM 901  C CA  . TYR A 1 151 ? 154.149 109.947 163.892 1.00 184.86 ? 151 TYR A CA  1 
ATOM 902  C C   . TYR A 1 151 ? 153.606 110.657 165.130 1.00 184.46 ? 151 TYR A C   1 
ATOM 903  O O   . TYR A 1 151 ? 154.376 111.155 165.963 1.00 181.62 ? 151 TYR A O   1 
ATOM 904  C CB  . TYR A 1 151 ? 154.014 110.805 162.620 1.00 188.36 ? 151 TYR A CB  1 
ATOM 905  C CG  . TYR A 1 151 ? 154.535 112.249 162.599 1.00 191.42 ? 151 TYR A CG  1 
ATOM 906  C CD1 . TYR A 1 151 ? 155.261 112.803 163.651 1.00 189.57 ? 151 TYR A CD1 1 
ATOM 907  C CD2 . TYR A 1 151 ? 154.285 113.059 161.495 1.00 190.50 ? 151 TYR A CD2 1 
ATOM 908  C CE1 . TYR A 1 151 ? 155.717 114.107 163.603 1.00 188.76 ? 151 TYR A CE1 1 
ATOM 909  C CE2 . TYR A 1 151 ? 154.739 114.363 161.441 1.00 187.81 ? 151 TYR A CE2 1 
ATOM 910  C CZ  . TYR A 1 151 ? 155.454 114.881 162.497 1.00 188.69 ? 151 TYR A CZ  1 
ATOM 911  O OH  . TYR A 1 151 ? 155.904 116.179 162.443 1.00 189.17 ? 151 TYR A OH  1 
ATOM 912  N N   . ASN A 1 152 ? 152.279 110.672 165.288 1.00 178.24 ? 152 ASN A N   1 
ATOM 913  C CA  . ASN A 1 152 ? 151.679 111.306 166.458 1.00 179.05 ? 152 ASN A CA  1 
ATOM 914  C C   . ASN A 1 152 ? 152.110 110.615 167.747 1.00 179.66 ? 152 ASN A C   1 
ATOM 915  O O   . ASN A 1 152 ? 152.361 111.278 168.761 1.00 176.92 ? 152 ASN A O   1 
ATOM 916  C CB  . ASN A 1 152 ? 150.156 111.306 166.331 1.00 180.78 ? 152 ASN A CB  1 
ATOM 917  C CG  . ASN A 1 152 ? 149.576 112.703 166.269 1.00 180.22 ? 152 ASN A CG  1 
ATOM 918  O OD1 . ASN A 1 152 ? 150.309 113.691 166.240 1.00 178.10 ? 152 ASN A OD1 1 
ATOM 919  N ND2 . ASN A 1 152 ? 148.252 112.793 166.246 1.00 181.83 ? 152 ASN A ND2 1 
ATOM 920  N N   . ARG A 1 153 ? 152.185 109.282 167.732 1.00 189.10 ? 153 ARG A N   1 
ATOM 921  C CA  . ARG A 1 153 ? 152.643 108.558 168.915 1.00 187.63 ? 153 ARG A CA  1 
ATOM 922  C C   . ARG A 1 153 ? 154.104 108.862 169.222 1.00 184.20 ? 153 ARG A C   1 
ATOM 923  O O   . ARG A 1 153 ? 154.473 109.053 170.387 1.00 181.57 ? 153 ARG A O   1 
ATOM 924  C CB  . ARG A 1 153 ? 152.442 107.054 168.730 1.00 188.87 ? 153 ARG A CB  1 
ATOM 925  C CG  . ARG A 1 153 ? 152.907 106.231 169.921 1.00 186.36 ? 153 ARG A CG  1 
ATOM 926  C CD  . ARG A 1 153 ? 152.867 104.739 169.629 1.00 187.29 ? 153 ARG A CD  1 
ATOM 927  N NE  . ARG A 1 153 ? 153.275 103.951 170.787 1.00 188.91 ? 153 ARG A NE  1 
ATOM 928  C CZ  . ARG A 1 153 ? 154.534 103.743 171.150 1.00 189.67 ? 153 ARG A CZ  1 
ATOM 929  N NH1 . ARG A 1 153 ? 155.546 104.245 170.459 1.00 189.28 ? 153 ARG A NH1 1 
ATOM 930  N NH2 . ARG A 1 153 ? 154.785 103.014 172.232 1.00 187.23 ? 153 ARG A NH2 1 
ATOM 931  N N   . SER A 1 154 ? 154.952 108.911 168.194 1.00 181.02 ? 154 SER A N   1 
ATOM 932  C CA  . SER A 1 154 ? 156.362 109.216 168.402 1.00 182.98 ? 154 SER A CA  1 
ATOM 933  C C   . SER A 1 154 ? 156.582 110.651 168.854 1.00 182.51 ? 154 SER A C   1 
ATOM 934  O O   . SER A 1 154 ? 157.638 110.953 169.424 1.00 182.45 ? 154 SER A O   1 
ATOM 935  C CB  . SER A 1 154 ? 157.154 108.951 167.122 1.00 183.95 ? 154 SER A CB  1 
ATOM 936  O OG  . SER A 1 154 ? 158.470 109.464 167.227 1.00 184.56 ? 154 SER A OG  1 
ATOM 937  N N   . ILE A 1 155 ? 155.617 111.538 168.598 1.00 178.34 ? 155 ILE A N   1 
ATOM 938  C CA  . ILE A 1 155 ? 155.736 112.924 169.048 1.00 178.58 ? 155 ILE A CA  1 
ATOM 939  C C   . ILE A 1 155 ? 155.878 112.985 170.566 1.00 180.96 ? 155 ILE A C   1 
ATOM 940  O O   . ILE A 1 155 ? 156.710 113.732 171.096 1.00 179.02 ? 155 ILE A O   1 
ATOM 941  C CB  . ILE A 1 155 ? 154.533 113.748 168.552 1.00 180.22 ? 155 ILE A CB  1 
ATOM 942  C CG1 . ILE A 1 155 ? 154.750 114.184 167.103 1.00 178.80 ? 155 ILE A CG1 1 
ATOM 943  C CG2 . ILE A 1 155 ? 154.293 114.961 169.440 1.00 180.86 ? 155 ILE A CG2 1 
ATOM 944  C CD1 . ILE A 1 155 ? 153.591 114.961 166.517 1.00 180.05 ? 155 ILE A CD1 1 
ATOM 945  N N   . ARG A 1 156 ? 155.083 112.188 171.289 1.00 203.38 ? 156 ARG A N   1 
ATOM 946  C CA  . ARG A 1 156 ? 155.173 112.186 172.747 1.00 204.23 ? 156 ARG A CA  1 
ATOM 947  C C   . ARG A 1 156 ? 156.506 111.626 173.231 1.00 201.12 ? 156 ARG A C   1 
ATOM 948  O O   . ARG A 1 156 ? 156.955 111.968 174.329 1.00 199.37 ? 156 ARG A O   1 
ATOM 949  C CB  . ARG A 1 156 ? 154.001 111.402 173.348 1.00 206.28 ? 156 ARG A CB  1 
ATOM 950  C CG  . ARG A 1 156 ? 154.219 109.900 173.492 1.00 205.04 ? 156 ARG A CG  1 
ATOM 951  C CD  . ARG A 1 156 ? 154.403 109.486 174.945 1.00 205.68 ? 156 ARG A CD  1 
ATOM 952  N NE  . ARG A 1 156 ? 154.726 108.070 175.069 1.00 206.41 ? 156 ARG A NE  1 
ATOM 953  C CZ  . ARG A 1 156 ? 154.920 107.443 176.222 1.00 207.25 ? 156 ARG A CZ  1 
ATOM 954  N NH1 . ARG A 1 156 ? 154.830 108.079 177.378 1.00 208.72 ? 156 ARG A NH1 1 
ATOM 955  N NH2 . ARG A 1 156 ? 155.209 106.144 176.213 1.00 203.46 ? 156 ARG A NH2 1 
ATOM 956  N N   . LEU A 1 157 ? 157.148 110.766 172.439 1.00 194.67 ? 157 LEU A N   1 
ATOM 957  C CA  . LEU A 1 157 ? 158.483 110.297 172.783 1.00 195.11 ? 157 LEU A CA  1 
ATOM 958  C C   . LEU A 1 157 ? 159.561 111.310 172.427 1.00 196.24 ? 157 LEU A C   1 
ATOM 959  O O   . LEU A 1 157 ? 160.652 111.261 173.004 1.00 194.66 ? 157 LEU A O   1 
ATOM 960  C CB  . LEU A 1 157 ? 158.773 108.968 172.081 1.00 198.12 ? 157 LEU A CB  1 
ATOM 961  C CG  . LEU A 1 157 ? 158.004 107.749 172.595 1.00 198.41 ? 157 LEU A CG  1 
ATOM 962  C CD1 . LEU A 1 157 ? 158.619 106.465 172.061 1.00 199.05 ? 157 LEU A CD1 1 
ATOM 963  C CD2 . LEU A 1 157 ? 157.966 107.735 174.115 1.00 197.33 ? 157 LEU A CD2 1 
ATOM 964  N N   . VAL A 1 158 ? 159.276 112.217 171.490 1.00 199.77 ? 158 VAL A N   1 
ATOM 965  C CA  . VAL A 1 158 ? 160.260 113.220 171.095 1.00 201.39 ? 158 VAL A CA  1 
ATOM 966  C C   . VAL A 1 158 ? 160.565 114.166 172.252 1.00 198.86 ? 158 VAL A C   1 
ATOM 967  O O   . VAL A 1 158 ? 161.731 114.489 172.517 1.00 197.40 ? 158 VAL A O   1 
ATOM 968  C CB  . VAL A 1 158 ? 159.767 113.983 169.851 1.00 200.83 ? 158 VAL A CB  1 
ATOM 969  C CG1 . VAL A 1 158 ? 160.541 115.279 169.668 1.00 201.47 ? 158 VAL A CG1 1 
ATOM 970  C CG2 . VAL A 1 158 ? 159.897 113.111 168.614 1.00 200.16 ? 158 VAL A CG2 1 
ATOM 971  N N   . GLN A 1 159 ? 159.537 114.600 172.978 1.00 203.85 ? 159 GLN A N   1 
ATOM 972  C CA  . GLN A 1 159 ? 159.685 115.636 174.001 1.00 206.51 ? 159 GLN A CA  1 
ATOM 973  C C   . GLN A 1 159 ? 160.370 115.145 175.280 1.00 207.66 ? 159 GLN A C   1 
ATOM 974  O O   . GLN A 1 159 ? 160.311 115.882 176.274 1.00 206.42 ? 159 GLN A O   1 
ATOM 975  C CB  . GLN A 1 159 ? 158.317 116.231 174.341 1.00 206.88 ? 159 GLN A CB  1 
ATOM 976  C CG  . GLN A 1 159 ? 157.218 115.204 174.562 1.00 207.94 ? 159 GLN A CG  1 
ATOM 977  C CD  . GLN A 1 159 ? 157.193 114.668 175.980 1.00 209.42 ? 159 GLN A CD  1 
ATOM 978  O OE1 . GLN A 1 159 ? 157.572 115.359 176.924 1.00 210.43 ? 159 GLN A OE1 1 
ATOM 979  N NE2 . GLN A 1 159 ? 156.744 113.428 176.137 1.00 206.75 ? 159 GLN A NE2 1 
ATOM 980  N N   . HIS A 1 160 ? 160.987 113.967 175.293 1.00 201.08 ? 160 HIS A N   1 
ATOM 981  C CA  . HIS A 1 160 ? 161.691 113.467 176.469 1.00 199.62 ? 160 HIS A CA  1 
ATOM 982  C C   . HIS A 1 160 ? 162.815 114.408 176.902 1.00 199.91 ? 160 HIS A C   1 
ATOM 983  O O   . HIS A 1 160 ? 163.386 115.126 176.081 1.00 201.13 ? 160 HIS A O   1 
ATOM 984  C CB  . HIS A 1 160 ? 162.256 112.071 176.195 1.00 200.17 ? 160 HIS A CB  1 
ATOM 985  C CG  . HIS A 1 160 ? 163.498 112.074 175.360 1.00 203.24 ? 160 HIS A CG  1 
ATOM 986  N ND1 . HIS A 1 160 ? 164.760 112.198 175.901 1.00 202.26 ? 160 HIS A ND1 1 
ATOM 987  C CD2 . HIS A 1 160 ? 163.672 111.975 174.021 1.00 200.77 ? 160 HIS A CD2 1 
ATOM 988  C CE1 . HIS A 1 160 ? 165.658 112.173 174.932 1.00 200.01 ? 160 HIS A CE1 1 
ATOM 989  N NE2 . HIS A 1 160 ? 165.023 112.038 173.781 1.00 199.81 ? 160 HIS A NE2 1 
ATOM 990  N N   . LYS A 1 183 ? 163.309 99.998  175.243 1.00 182.55 ? 183 LYS A N   1 
ATOM 991  C CA  . LYS A 1 183 ? 162.820 100.655 174.037 1.00 186.10 ? 183 LYS A CA  1 
ATOM 992  C C   . LYS A 1 183 ? 161.516 100.022 173.560 1.00 189.34 ? 183 LYS A C   1 
ATOM 993  O O   . LYS A 1 183 ? 161.529 99.040  172.818 1.00 187.02 ? 183 LYS A O   1 
ATOM 994  C CB  . LYS A 1 183 ? 163.871 100.595 172.928 1.00 180.83 ? 183 LYS A CB  1 
ATOM 995  N N   . GLU A 1 184 ? 160.393 100.592 173.991 1.00 203.92 ? 184 GLU A N   1 
ATOM 996  C CA  . GLU A 1 184 ? 159.073 100.092 173.606 1.00 202.32 ? 184 GLU A CA  1 
ATOM 997  C C   . GLU A 1 184 ? 158.583 100.798 172.340 1.00 201.72 ? 184 GLU A C   1 
ATOM 998  O O   . GLU A 1 184 ? 157.502 101.384 172.288 1.00 199.16 ? 184 GLU A O   1 
ATOM 999  C CB  . GLU A 1 184 ? 158.088 100.265 174.756 1.00 201.53 ? 184 GLU A CB  1 
ATOM 1000 N N   . ARG A 1 185 ? 159.413 100.731 171.306 1.00 217.26 ? 185 ARG A N   1 
ATOM 1001 C CA  . ARG A 1 185 ? 159.114 101.351 170.021 1.00 215.58 ? 185 ARG A CA  1 
ATOM 1002 C C   . ARG A 1 185 ? 159.167 100.377 168.856 1.00 218.90 ? 185 ARG A C   1 
ATOM 1003 O O   . ARG A 1 185 ? 158.369 100.499 167.926 1.00 217.93 ? 185 ARG A O   1 
ATOM 1004 C CB  . ARG A 1 185 ? 160.085 102.512 169.757 1.00 213.54 ? 185 ARG A CB  1 
ATOM 1005 N N   . TYR A 1 186 ? 160.095 99.416  168.878 1.00 229.36 ? 186 TYR A N   1 
ATOM 1006 C CA  . TYR A 1 186 ? 160.185 98.452  167.784 1.00 228.32 ? 186 TYR A CA  1 
ATOM 1007 C C   . TYR A 1 186 ? 158.931 97.592  167.695 1.00 229.23 ? 186 TYR A C   1 
ATOM 1008 O O   . TYR A 1 186 ? 158.400 97.366  166.601 1.00 227.43 ? 186 TYR A O   1 
ATOM 1009 C CB  . TYR A 1 186 ? 161.427 97.579  167.956 1.00 225.15 ? 186 TYR A CB  1 
ATOM 1010 N N   . PHE A 1 187 ? 158.437 97.111  168.836 1.00 238.34 ? 187 PHE A N   1 
ATOM 1011 C CA  . PHE A 1 187 ? 157.216 96.318  168.866 1.00 237.11 ? 187 PHE A CA  1 
ATOM 1012 C C   . PHE A 1 187 ? 155.958 97.174  168.915 1.00 238.03 ? 187 PHE A C   1 
ATOM 1013 O O   . PHE A 1 187 ? 154.853 96.621  168.923 1.00 237.34 ? 187 PHE A O   1 
ATOM 1014 C CB  . PHE A 1 187 ? 157.236 95.370  170.067 1.00 235.39 ? 187 PHE A CB  1 
ATOM 1015 N N   . GLU A 1 188 ? 156.097 98.500  168.947 1.00 229.87 ? 188 GLU A N   1 
ATOM 1016 C CA  . GLU A 1 188 ? 154.950 99.383  169.101 1.00 229.30 ? 188 GLU A CA  1 
ATOM 1017 C C   . GLU A 1 188 ? 154.046 99.414  167.876 1.00 228.37 ? 188 GLU A C   1 
ATOM 1018 O O   . GLU A 1 188 ? 152.914 99.900  167.977 1.00 229.95 ? 188 GLU A O   1 
ATOM 1019 C CB  . GLU A 1 188 ? 155.423 100.804 169.419 1.00 226.51 ? 188 GLU A CB  1 
ATOM 1020 N N   . PHE A 1 189 ? 154.506 98.915  166.728 1.00 196.91 ? 189 PHE A N   1 
ATOM 1021 C CA  . PHE A 1 189 ? 153.733 98.942  165.487 1.00 195.56 ? 189 PHE A CA  1 
ATOM 1022 C C   . PHE A 1 189 ? 153.748 97.550  164.869 1.00 192.97 ? 189 PHE A C   1 
ATOM 1023 O O   . PHE A 1 189 ? 154.472 97.298  163.894 1.00 192.97 ? 189 PHE A O   1 
ATOM 1024 C CB  . PHE A 1 189 ? 154.271 99.984  164.505 1.00 196.13 ? 189 PHE A CB  1 
ATOM 1025 C CG  . PHE A 1 189 ? 154.848 101.206 165.166 1.00 195.93 ? 189 PHE A CG  1 
ATOM 1026 C CD1 . PHE A 1 189 ? 154.091 102.355 165.296 1.00 194.22 ? 189 PHE A CD1 1 
ATOM 1027 C CD2 . PHE A 1 189 ? 156.166 101.229 165.592 1.00 195.86 ? 189 PHE A CD2 1 
ATOM 1028 C CE1 . PHE A 1 189 ? 154.617 103.481 165.895 1.00 194.92 ? 189 PHE A CE1 1 
ATOM 1029 C CE2 . PHE A 1 189 ? 156.698 102.358 166.182 1.00 197.97 ? 189 PHE A CE2 1 
ATOM 1030 C CZ  . PHE A 1 189 ? 155.922 103.484 166.331 1.00 198.53 ? 189 PHE A CZ  1 
ATOM 1031 N N   . PRO A 1 190 ? 152.961 96.616  165.409 1.00 177.42 ? 190 PRO A N   1 
ATOM 1032 C CA  . PRO A 1 190 ? 152.925 95.264  164.836 1.00 179.13 ? 190 PRO A CA  1 
ATOM 1033 C C   . PRO A 1 190 ? 152.273 95.233  163.463 1.00 182.29 ? 190 PRO A C   1 
ATOM 1034 O O   . PRO A 1 190 ? 152.668 94.439  162.603 1.00 185.02 ? 190 PRO A O   1 
ATOM 1035 C CB  . PRO A 1 190 ? 152.112 94.470  165.864 1.00 178.10 ? 190 PRO A CB  1 
ATOM 1036 C CG  . PRO A 1 190 ? 151.250 95.483  166.527 1.00 178.63 ? 190 PRO A CG  1 
ATOM 1037 C CD  . PRO A 1 190 ? 152.012 96.778  166.524 1.00 178.73 ? 190 PRO A CD  1 
ATOM 1038 N N   . LEU A 1 191 ? 151.273 96.089  163.252 1.00 161.24 ? 191 LEU A N   1 
ATOM 1039 C CA  . LEU A 1 191 ? 150.561 96.143  161.983 1.00 160.04 ? 191 LEU A CA  1 
ATOM 1040 C C   . LEU A 1 191 ? 151.483 96.573  160.851 1.00 156.91 ? 191 LEU A C   1 
ATOM 1041 O O   . LEU A 1 191 ? 151.447 95.996  159.760 1.00 153.84 ? 191 LEU A O   1 
ATOM 1042 C CB  . LEU A 1 191 ? 149.364 97.091  162.079 1.00 157.92 ? 191 LEU A CB  1 
ATOM 1043 C CG  . LEU A 1 191 ? 148.272 96.721  163.084 1.00 162.70 ? 191 LEU A CG  1 
ATOM 1044 C CD1 . LEU A 1 191 ? 147.004 97.511  162.805 1.00 160.86 ? 191 LEU A CD1 1 
ATOM 1045 C CD2 . LEU A 1 191 ? 147.992 95.227  163.050 1.00 164.64 ? 191 LEU A CD2 1 
ATOM 1046 N N   . LEU A 1 192 ? 152.329 97.572  161.112 1.00 157.70 ? 192 LEU A N   1 
ATOM 1047 C CA  . LEU A 1 192 ? 153.245 98.064  160.090 1.00 159.86 ? 192 LEU A CA  1 
ATOM 1048 C C   . LEU A 1 192 ? 154.271 97.019  159.678 1.00 162.19 ? 192 LEU A C   1 
ATOM 1049 O O   . LEU A 1 192 ? 154.922 97.182  158.642 1.00 166.85 ? 192 LEU A O   1 
ATOM 1050 C CB  . LEU A 1 192 ? 153.958 99.325  160.581 1.00 161.86 ? 192 LEU A CB  1 
ATOM 1051 C CG  . LEU A 1 192 ? 154.491 100.273 159.506 1.00 163.33 ? 192 LEU A CG  1 
ATOM 1052 C CD1 . LEU A 1 192 ? 153.393 100.662 158.538 1.00 161.09 ? 192 LEU A CD1 1 
ATOM 1053 C CD2 . LEU A 1 192 ? 155.101 101.512 160.138 1.00 165.77 ? 192 LEU A CD2 1 
ATOM 1054 N N   . GLU A 1 193 ? 154.436 95.953  160.458 1.00 172.27 ? 193 GLU A N   1 
ATOM 1055 C CA  . GLU A 1 193 ? 155.348 94.882  160.083 1.00 173.82 ? 193 GLU A CA  1 
ATOM 1056 C C   . GLU A 1 193 ? 154.608 93.710  159.447 1.00 173.22 ? 193 GLU A C   1 
ATOM 1057 O O   . GLU A 1 193 ? 155.010 93.241  158.380 1.00 174.07 ? 193 GLU A O   1 
ATOM 1058 C CB  . GLU A 1 193 ? 156.197 94.486  161.315 1.00 175.24 ? 193 GLU A CB  1 
ATOM 1059 C CG  . GLU A 1 193 ? 157.037 93.174  161.332 1.00 179.03 ? 193 GLU A CG  1 
ATOM 1060 C CD  . GLU A 1 193 ? 156.264 91.862  161.298 1.00 182.09 ? 193 GLU A CD  1 
ATOM 1061 O OE1 . GLU A 1 193 ? 156.904 90.809  161.101 1.00 184.00 ? 193 GLU A OE1 1 
ATOM 1062 O OE2 . GLU A 1 193 ? 155.055 91.860  161.599 1.00 181.42 ? 193 GLU A OE2 1 
ATOM 1063 N N   . ARG A 1 194 ? 153.504 93.262  160.050 1.00 170.95 ? 194 ARG A N   1 
ATOM 1064 C CA  . ARG A 1 194 ? 152.763 92.134  159.489 1.00 172.60 ? 194 ARG A CA  1 
ATOM 1065 C C   . ARG A 1 194 ? 152.132 92.485  158.148 1.00 171.37 ? 194 ARG A C   1 
ATOM 1066 O O   . ARG A 1 194 ? 152.267 91.728  157.178 1.00 173.69 ? 194 ARG A O   1 
ATOM 1067 C CB  . ARG A 1 194 ? 151.699 91.661  160.480 1.00 173.24 ? 194 ARG A CB  1 
ATOM 1068 C CG  . ARG A 1 194 ? 151.939 90.258  161.017 1.00 172.37 ? 194 ARG A CG  1 
ATOM 1069 C CD  . ARG A 1 194 ? 150.700 89.704  161.699 1.00 173.99 ? 194 ARG A CD  1 
ATOM 1070 N NE  . ARG A 1 194 ? 150.352 90.460  162.894 1.00 179.20 ? 194 ARG A NE  1 
ATOM 1071 C CZ  . ARG A 1 194 ? 150.771 90.165  164.118 1.00 179.17 ? 194 ARG A CZ  1 
ATOM 1072 N NH1 . ARG A 1 194 ? 151.561 89.129  164.345 1.00 177.81 ? 194 ARG A NH1 1 
ATOM 1073 N NH2 . ARG A 1 194 ? 150.390 90.928  165.137 1.00 175.15 ? 194 ARG A NH2 1 
ATOM 1074 N N   . TYR A 1 195 ? 151.441 93.625  158.070 1.00 149.37 ? 195 TYR A N   1 
ATOM 1075 C CA  . TYR A 1 195 ? 150.806 94.023  156.820 1.00 146.94 ? 195 TYR A CA  1 
ATOM 1076 C C   . TYR A 1 195 ? 151.828 94.254  155.717 1.00 145.93 ? 195 TYR A C   1 
ATOM 1077 O O   . TYR A 1 195 ? 151.603 93.839  154.574 1.00 147.39 ? 195 TYR A O   1 
ATOM 1078 C CB  . TYR A 1 195 ? 149.940 95.267  157.058 1.00 148.23 ? 195 TYR A CB  1 
ATOM 1079 C CG  . TYR A 1 195 ? 149.516 96.047  155.825 1.00 146.94 ? 195 TYR A CG  1 
ATOM 1080 C CD1 . TYR A 1 195 ? 150.377 96.948  155.204 1.00 145.98 ? 195 TYR A CD1 1 
ATOM 1081 C CD2 . TYR A 1 195 ? 148.258 95.863  155.271 1.00 151.02 ? 195 TYR A CD2 1 
ATOM 1082 C CE1 . TYR A 1 195 ? 149.991 97.647  154.084 1.00 149.13 ? 195 TYR A CE1 1 
ATOM 1083 C CE2 . TYR A 1 195 ? 147.864 96.561  154.149 1.00 154.21 ? 195 TYR A CE2 1 
ATOM 1084 C CZ  . TYR A 1 195 ? 148.735 97.452  153.561 1.00 154.37 ? 195 TYR A CZ  1 
ATOM 1085 O OH  . TYR A 1 195 ? 148.350 98.150  152.442 1.00 158.49 ? 195 TYR A OH  1 
ATOM 1086 N N   . LEU A 1 196 ? 152.944 94.900  156.033 1.00 147.19 ? 196 LEU A N   1 
ATOM 1087 C CA  . LEU A 1 196 ? 153.982 95.174  155.054 1.00 151.18 ? 196 LEU A CA  1 
ATOM 1088 C C   . LEU A 1 196 ? 154.730 93.915  154.633 1.00 153.44 ? 196 LEU A C   1 
ATOM 1089 O O   . LEU A 1 196 ? 155.215 93.848  153.501 1.00 158.17 ? 196 LEU A O   1 
ATOM 1090 C CB  . LEU A 1 196 ? 154.947 96.227  155.607 1.00 150.47 ? 196 LEU A CB  1 
ATOM 1091 C CG  . LEU A 1 196 ? 156.255 96.603  154.910 1.00 152.43 ? 196 LEU A CG  1 
ATOM 1092 C CD1 . LEU A 1 196 ? 156.556 98.057  155.200 1.00 149.65 ? 196 LEU A CD1 1 
ATOM 1093 C CD2 . LEU A 1 196 ? 157.419 95.745  155.381 1.00 152.23 ? 196 LEU A CD2 1 
ATOM 1094 N N   . ALA A 1 197 ? 154.822 92.912  155.505 1.00 155.08 ? 197 ALA A N   1 
ATOM 1095 C CA  . ALA A 1 197 ? 155.444 91.653  155.125 1.00 155.93 ? 197 ALA A CA  1 
ATOM 1096 C C   . ALA A 1 197 ? 154.496 90.844  154.254 1.00 159.79 ? 197 ALA A C   1 
ATOM 1097 O O   . ALA A 1 197 ? 154.934 90.119  153.357 1.00 162.42 ? 197 ALA A O   1 
ATOM 1098 C CB  . ALA A 1 197 ? 155.846 90.851  156.365 1.00 156.84 ? 197 ALA A CB  1 
ATOM 1099 N N   . CYS A 1 198 ? 153.193 90.963  154.515 1.00 169.10 ? 198 CYS A N   1 
ATOM 1100 C CA  . CYS A 1 198 ? 152.219 90.283  153.668 1.00 169.36 ? 198 CYS A CA  1 
ATOM 1101 C C   . CYS A 1 198 ? 152.201 90.865  152.262 1.00 168.54 ? 198 CYS A C   1 
ATOM 1102 O O   . CYS A 1 198 ? 152.128 90.115  151.282 1.00 171.62 ? 198 CYS A O   1 
ATOM 1103 C CB  . CYS A 1 198 ? 150.828 90.365  154.292 1.00 171.34 ? 198 CYS A CB  1 
ATOM 1104 S SG  . CYS A 1 198 ? 149.472 90.252  153.102 1.00 181.41 ? 198 CYS A SG  1 
ATOM 1105 N N   . LYS A 1 199 ? 152.276 92.191  152.140 1.00 143.65 ? 199 LYS A N   1 
ATOM 1106 C CA  . LYS A 1 199 ? 152.241 92.819  150.828 1.00 141.50 ? 199 LYS A CA  1 
ATOM 1107 C C   . LYS A 1 199 ? 153.542 92.627  150.063 1.00 142.23 ? 199 LYS A C   1 
ATOM 1108 O O   . LYS A 1 199 ? 153.526 92.558  148.830 1.00 147.59 ? 199 LYS A O   1 
ATOM 1109 C CB  . LYS A 1 199 ? 151.929 94.308  150.969 1.00 143.21 ? 199 LYS A CB  1 
ATOM 1110 C CG  . LYS A 1 199 ? 151.429 94.963  149.697 1.00 147.09 ? 199 LYS A CG  1 
ATOM 1111 C CD  . LYS A 1 199 ? 150.108 94.362  149.237 1.00 148.65 ? 199 LYS A CD  1 
ATOM 1112 C CE  . LYS A 1 199 ? 149.057 94.418  150.332 1.00 145.16 ? 199 LYS A CE  1 
ATOM 1113 N NZ  . LYS A 1 199 ? 148.875 95.801  150.844 1.00 148.47 ? 199 LYS A NZ  1 
ATOM 1114 N N   . GLN A 1 200 ? 154.670 92.541  150.768 1.00 151.27 ? 200 GLN A N   1 
ATOM 1115 C CA  . GLN A 1 200 ? 155.955 92.350  150.107 1.00 153.61 ? 200 GLN A CA  1 
ATOM 1116 C C   . GLN A 1 200 ? 156.074 90.979  149.454 1.00 154.94 ? 200 GLN A C   1 
ATOM 1117 O O   . GLN A 1 200 ? 156.836 90.828  148.494 1.00 159.93 ? 200 GLN A O   1 
ATOM 1118 C CB  . GLN A 1 200 ? 157.088 92.555  151.111 1.00 155.86 ? 200 GLN A CB  1 
ATOM 1119 C CG  . GLN A 1 200 ? 158.455 92.765  150.490 1.00 154.81 ? 200 GLN A CG  1 
ATOM 1120 C CD  . GLN A 1 200 ? 159.303 91.513  150.527 1.00 157.77 ? 200 GLN A CD  1 
ATOM 1121 O OE1 . GLN A 1 200 ? 158.807 90.423  150.811 1.00 155.91 ? 200 GLN A OE1 1 
ATOM 1122 N NE2 . GLN A 1 200 ? 160.592 91.661  150.245 1.00 157.95 ? 200 GLN A NE2 1 
ATOM 1123 N N   . ARG A 1 201 ? 155.342 89.981  149.945 1.00 162.92 ? 201 ARG A N   1 
ATOM 1124 C CA  . ARG A 1 201 ? 155.390 88.640  149.380 1.00 164.28 ? 201 ARG A CA  1 
ATOM 1125 C C   . ARG A 1 201 ? 154.426 88.441  148.221 1.00 166.54 ? 201 ARG A C   1 
ATOM 1126 O O   . ARG A 1 201 ? 154.459 87.382  147.586 1.00 167.52 ? 201 ARG A O   1 
ATOM 1127 C CB  . ARG A 1 201 ? 155.093 87.599  150.463 1.00 167.48 ? 201 ARG A CB  1 
ATOM 1128 C CG  . ARG A 1 201 ? 156.163 87.497  151.533 1.00 170.85 ? 201 ARG A CG  1 
ATOM 1129 C CD  . ARG A 1 201 ? 157.431 86.885  150.967 1.00 172.86 ? 201 ARG A CD  1 
ATOM 1130 N NE  . ARG A 1 201 ? 157.144 85.785  150.056 1.00 177.51 ? 201 ARG A NE  1 
ATOM 1131 C CZ  . ARG A 1 201 ? 156.916 84.535  150.434 1.00 176.05 ? 201 ARG A CZ  1 
ATOM 1132 N NH1 . ARG A 1 201 ? 156.941 84.183  151.709 1.00 173.42 ? 201 ARG A NH1 1 
ATOM 1133 N NH2 . ARG A 1 201 ? 156.657 83.615  149.510 1.00 172.10 ? 201 ARG A NH2 1 
ATOM 1134 N N   . SER A 1 202 ? 153.574 89.415  147.932 1.00 150.89 ? 202 SER A N   1 
ATOM 1135 C CA  . SER A 1 202 ? 152.609 89.295  146.852 1.00 151.23 ? 202 SER A CA  1 
ATOM 1136 C C   . SER A 1 202 ? 153.241 89.681  145.518 1.00 150.96 ? 202 SER A C   1 
ATOM 1137 O O   . SER A 1 202 ? 154.386 90.130  145.444 1.00 153.98 ? 202 SER A O   1 
ATOM 1138 C CB  . SER A 1 202 ? 151.385 90.163  147.129 1.00 147.50 ? 202 SER A CB  1 
ATOM 1139 O OG  . SER A 1 202 ? 150.732 90.518  145.924 1.00 150.21 ? 202 SER A OG  1 
ATOM 1140 N N   . HIS A 1 203 ? 152.471 89.487  144.445 1.00 131.31 ? 203 HIS A N   1 
ATOM 1141 C CA  . HIS A 1 203 ? 152.835 89.973  143.119 1.00 125.72 ? 203 HIS A CA  1 
ATOM 1142 C C   . HIS A 1 203 ? 151.613 90.503  142.379 1.00 127.11 ? 203 HIS A C   1 
ATOM 1143 O O   . HIS A 1 203 ? 151.525 90.381  141.154 1.00 131.51 ? 203 HIS A O   1 
ATOM 1144 C CB  . HIS A 1 203 ? 153.508 88.881  142.290 1.00 130.32 ? 203 HIS A CB  1 
ATOM 1145 C CG  . HIS A 1 203 ? 154.695 88.261  142.957 1.00 136.24 ? 203 HIS A CG  1 
ATOM 1146 N ND1 . HIS A 1 203 ? 155.806 88.989  143.324 1.00 139.00 ? 203 HIS A ND1 1 
ATOM 1147 C CD2 . HIS A 1 203 ? 154.945 86.984  143.326 1.00 137.07 ? 203 HIS A CD2 1 
ATOM 1148 C CE1 . HIS A 1 203 ? 156.689 88.187  143.889 1.00 138.57 ? 203 HIS A CE1 1 
ATOM 1149 N NE2 . HIS A 1 203 ? 156.191 86.964  143.902 1.00 139.66 ? 203 HIS A NE2 1 
ATOM 1150 N N   . SER A 1 204 ? 150.668 91.098  143.103 1.00 137.27 ? 204 SER A N   1 
ATOM 1151 C CA  . SER A 1 204 ? 149.339 91.339  142.557 1.00 141.68 ? 204 SER A CA  1 
ATOM 1152 C C   . SER A 1 204 ? 149.299 92.440  141.506 1.00 139.83 ? 204 SER A C   1 
ATOM 1153 O O   . SER A 1 204 ? 149.013 92.167  140.338 1.00 142.65 ? 204 SER A O   1 
ATOM 1154 C CB  . SER A 1 204 ? 148.364 91.681  143.684 1.00 150.13 ? 204 SER A CB  1 
ATOM 1155 O OG  . SER A 1 204 ? 147.346 92.551  143.222 1.00 153.63 ? 204 SER A OG  1 
ATOM 1156 N N   . LEU A 1 205 ? 149.587 93.681  141.895 1.00 129.21 ? 205 LEU A N   1 
ATOM 1157 C CA  . LEU A 1 205 ? 149.372 94.806  140.994 1.00 129.88 ? 205 LEU A CA  1 
ATOM 1158 C C   . LEU A 1 205 ? 150.649 95.320  140.345 1.00 130.01 ? 205 LEU A C   1 
ATOM 1159 O O   . LEU A 1 205 ? 150.570 96.186  139.468 1.00 129.97 ? 205 LEU A O   1 
ATOM 1160 C CB  . LEU A 1 205 ? 148.663 95.958  141.721 1.00 130.48 ? 205 LEU A CB  1 
ATOM 1161 C CG  . LEU A 1 205 ? 149.424 97.048  142.478 1.00 128.76 ? 205 LEU A CG  1 
ATOM 1162 C CD1 . LEU A 1 205 ? 148.429 98.010  143.089 1.00 135.25 ? 205 LEU A CD1 1 
ATOM 1163 C CD2 . LEU A 1 205 ? 150.308 96.482  143.558 1.00 127.25 ? 205 LEU A CD2 1 
ATOM 1164 N N   . VAL A 1 206 ? 151.819 94.820  140.749 1.00 133.64 ? 206 VAL A N   1 
ATOM 1165 C CA  . VAL A 1 206 ? 153.040 95.154  140.025 1.00 129.80 ? 206 VAL A CA  1 
ATOM 1166 C C   . VAL A 1 206 ? 152.980 94.598  138.608 1.00 132.36 ? 206 VAL A C   1 
ATOM 1167 O O   . VAL A 1 206 ? 153.486 95.218  137.663 1.00 141.25 ? 206 VAL A O   1 
ATOM 1168 C CB  . VAL A 1 206 ? 154.276 94.655  140.800 1.00 129.79 ? 206 VAL A CB  1 
ATOM 1169 C CG1 . VAL A 1 206 ? 154.229 93.148  140.998 1.00 134.17 ? 206 VAL A CG1 1 
ATOM 1170 C CG2 . VAL A 1 206 ? 155.557 95.065  140.094 1.00 128.25 ? 206 VAL A CG2 1 
ATOM 1171 N N   . ALA A 1 207 ? 152.342 93.437  138.433 1.00 137.01 ? 207 ALA A N   1 
ATOM 1172 C CA  . ALA A 1 207 ? 152.194 92.859  137.103 1.00 143.74 ? 207 ALA A CA  1 
ATOM 1173 C C   . ALA A 1 207 ? 151.371 93.763  136.200 1.00 145.48 ? 207 ALA A C   1 
ATOM 1174 O O   . ALA A 1 207 ? 151.710 93.947  135.027 1.00 156.32 ? 207 ALA A O   1 
ATOM 1175 C CB  . ALA A 1 207 ? 151.558 91.475  137.200 1.00 145.47 ? 207 ALA A CB  1 
ATOM 1176 N N   . THR A 1 208 ? 150.290 94.344  136.726 1.00 122.72 ? 208 THR A N   1 
ATOM 1177 C CA  . THR A 1 208 ? 149.482 95.260  135.925 1.00 127.75 ? 208 THR A CA  1 
ATOM 1178 C C   . THR A 1 208 ? 150.269 96.511  135.557 1.00 133.23 ? 208 THR A C   1 
ATOM 1179 O O   . THR A 1 208 ? 150.170 97.008  134.427 1.00 139.43 ? 208 THR A O   1 
ATOM 1180 C CB  . THR A 1 208 ? 148.214 95.641  136.683 1.00 125.78 ? 208 THR A CB  1 
ATOM 1181 O OG1 . THR A 1 208 ? 148.511 96.705  137.595 1.00 127.60 ? 208 THR A OG1 1 
ATOM 1182 C CG2 . THR A 1 208 ? 147.690 94.452  137.462 1.00 136.29 ? 208 THR A CG2 1 
ATOM 1183 N N   . TYR A 1 209 ? 151.048 97.038  136.504 1.00 116.22 ? 209 TYR A N   1 
ATOM 1184 C CA  . TYR A 1 209 ? 151.836 98.235  136.232 1.00 116.12 ? 209 TYR A CA  1 
ATOM 1185 C C   . TYR A 1 209 ? 152.873 97.978  135.150 1.00 118.47 ? 209 TYR A C   1 
ATOM 1186 O O   . TYR A 1 209 ? 153.094 98.825  134.279 1.00 129.81 ? 209 TYR A O   1 
ATOM 1187 C CB  . TYR A 1 209 ? 152.507 98.722  137.514 1.00 113.64 ? 209 TYR A CB  1 
ATOM 1188 C CG  . TYR A 1 209 ? 153.320 99.979  137.335 1.00 110.53 ? 209 TYR A CG  1 
ATOM 1189 C CD1 . TYR A 1 209 ? 152.705 101.192 137.060 1.00 113.99 ? 209 TYR A CD1 1 
ATOM 1190 C CD2 . TYR A 1 209 ? 154.701 99.956  137.442 1.00 109.08 ? 209 TYR A CD2 1 
ATOM 1191 C CE1 . TYR A 1 209 ? 153.445 102.344 136.897 1.00 116.90 ? 209 TYR A CE1 1 
ATOM 1192 C CE2 . TYR A 1 209 ? 155.447 101.101 137.280 1.00 114.02 ? 209 TYR A CE2 1 
ATOM 1193 C CZ  . TYR A 1 209 ? 154.815 102.292 137.007 1.00 119.65 ? 209 TYR A CZ  1 
ATOM 1194 O OH  . TYR A 1 209 ? 155.558 103.436 136.846 1.00 124.74 ? 209 TYR A OH  1 
ATOM 1195 N N   . LEU A 1 210 ? 153.526 96.815  135.190 1.00 115.14 ? 210 LEU A N   1 
ATOM 1196 C CA  . LEU A 1 210 ? 154.450 96.464  134.116 1.00 114.87 ? 210 LEU A CA  1 
ATOM 1197 C C   . LEU A 1 210 ? 153.717 96.256  132.797 1.00 125.41 ? 210 LEU A C   1 
ATOM 1198 O O   . LEU A 1 210 ? 154.180 96.711  131.742 1.00 133.04 ? 210 LEU A O   1 
ATOM 1199 C CB  . LEU A 1 210 ? 155.238 95.210  134.489 1.00 112.31 ? 210 LEU A CB  1 
ATOM 1200 C CG  . LEU A 1 210 ? 156.691 95.428  134.899 1.00 120.71 ? 210 LEU A CG  1 
ATOM 1201 C CD1 . LEU A 1 210 ? 156.760 96.115  136.247 1.00 123.79 ? 210 LEU A CD1 1 
ATOM 1202 C CD2 . LEU A 1 210 ? 157.437 94.107  134.930 1.00 127.50 ? 210 LEU A CD2 1 
ATOM 1203 N N   . LEU A 1 211 ? 152.569 95.581  132.840 1.00 132.25 ? 211 LEU A N   1 
ATOM 1204 C CA  . LEU A 1 211 ? 151.877 95.191  131.622 1.00 132.70 ? 211 LEU A CA  1 
ATOM 1205 C C   . LEU A 1 211 ? 151.269 96.378  130.894 1.00 136.83 ? 211 LEU A C   1 
ATOM 1206 O O   . LEU A 1 211 ? 151.150 96.334  129.668 1.00 151.20 ? 211 LEU A O   1 
ATOM 1207 C CB  . LEU A 1 211 ? 150.799 94.157  131.950 1.00 127.69 ? 211 LEU A CB  1 
ATOM 1208 C CG  . LEU A 1 211 ? 150.048 93.515  130.785 1.00 128.31 ? 211 LEU A CG  1 
ATOM 1209 C CD1 . LEU A 1 211 ? 150.050 92.008  130.931 1.00 136.72 ? 211 LEU A CD1 1 
ATOM 1210 C CD2 . LEU A 1 211 ? 148.631 94.039  130.716 1.00 129.39 ? 211 LEU A CD2 1 
ATOM 1211 N N   . ARG A 1 212 ? 150.896 97.440  131.610 1.00 126.50 ? 212 ARG A N   1 
ATOM 1212 C CA  . ARG A 1 212 ? 150.395 98.636  130.936 1.00 132.11 ? 212 ARG A CA  1 
ATOM 1213 C C   . ARG A 1 212 ? 151.457 99.232  130.015 1.00 137.40 ? 212 ARG A C   1 
ATOM 1214 O O   . ARG A 1 212 ? 151.209 99.473  128.823 1.00 143.03 ? 212 ARG A O   1 
ATOM 1215 C CB  . ARG A 1 212 ? 149.939 99.661  131.972 1.00 121.20 ? 212 ARG A CB  1 
ATOM 1216 C CG  . ARG A 1 212 ? 149.817 101.070 131.435 1.00 126.79 ? 212 ARG A CG  1 
ATOM 1217 C CD  . ARG A 1 212 ? 149.943 102.090 132.547 1.00 129.26 ? 212 ARG A CD  1 
ATOM 1218 N NE  . ARG A 1 212 ? 149.221 103.319 132.237 1.00 137.42 ? 212 ARG A NE  1 
ATOM 1219 C CZ  . ARG A 1 212 ? 148.697 104.127 133.145 1.00 139.71 ? 212 ARG A CZ  1 
ATOM 1220 N NH1 . ARG A 1 212 ? 148.798 103.871 134.439 1.00 141.29 ? 212 ARG A NH1 1 
ATOM 1221 N NH2 . ARG A 1 212 ? 148.055 105.221 132.747 1.00 137.38 ? 212 ARG A NH2 1 
ATOM 1222 N N   . ASN A 1 213 ? 152.661 99.452  130.547 1.00 134.06 ? 213 ASN A N   1 
ATOM 1223 C CA  . ASN A 1 213 ? 153.745 99.980  129.728 1.00 137.85 ? 213 ASN A CA  1 
ATOM 1224 C C   . ASN A 1 213 ? 154.174 98.989  128.654 1.00 140.76 ? 213 ASN A C   1 
ATOM 1225 O O   . ASN A 1 213 ? 154.535 99.400  127.544 1.00 146.24 ? 213 ASN A O   1 
ATOM 1226 C CB  . ASN A 1 213 ? 154.930 100.360 130.611 1.00 134.59 ? 213 ASN A CB  1 
ATOM 1227 C CG  . ASN A 1 213 ? 154.566 101.393 131.652 1.00 136.96 ? 213 ASN A CG  1 
ATOM 1228 O OD1 . ASN A 1 213 ? 153.488 101.983 131.606 1.00 136.22 ? 213 ASN A OD1 1 
ATOM 1229 N ND2 . ASN A 1 213 ? 155.466 101.620 132.600 1.00 141.80 ? 213 ASN A ND2 1 
ATOM 1230 N N   . SER A 1 214 ? 154.136 97.688  128.959 1.00 127.62 ? 214 SER A N   1 
ATOM 1231 C CA  . SER A 1 214 ? 154.466 96.692  127.946 1.00 128.82 ? 214 SER A CA  1 
ATOM 1232 C C   . SER A 1 214 ? 153.487 96.748  126.779 1.00 133.92 ? 214 SER A C   1 
ATOM 1233 O O   . SER A 1 214 ? 153.892 96.667  125.613 1.00 140.97 ? 214 SER A O   1 
ATOM 1234 C CB  . SER A 1 214 ? 154.485 95.298  128.567 1.00 132.90 ? 214 SER A CB  1 
ATOM 1235 O OG  . SER A 1 214 ? 155.332 94.430  127.839 1.00 139.44 ? 214 SER A OG  1 
ATOM 1236 N N   . LEU A 1 215 ? 152.194 96.897  127.074 1.00 126.55 ? 215 LEU A N   1 
ATOM 1237 C CA  . LEU A 1 215 ? 151.191 97.015  126.021 1.00 124.79 ? 215 LEU A CA  1 
ATOM 1238 C C   . LEU A 1 215 ? 151.394 98.283  125.206 1.00 130.48 ? 215 LEU A C   1 
ATOM 1239 O O   . LEU A 1 215 ? 151.246 98.267  123.978 1.00 141.33 ? 215 LEU A O   1 
ATOM 1240 C CB  . LEU A 1 215 ? 149.791 96.993  126.628 1.00 122.48 ? 215 LEU A CB  1 
ATOM 1241 C CG  . LEU A 1 215 ? 149.172 95.621  126.889 1.00 131.62 ? 215 LEU A CG  1 
ATOM 1242 C CD1 . LEU A 1 215 ? 147.660 95.736  126.974 1.00 131.46 ? 215 LEU A CD1 1 
ATOM 1243 C CD2 . LEU A 1 215 ? 149.576 94.629  125.812 1.00 130.59 ? 215 LEU A CD2 1 
ATOM 1244 N N   . LEU A 1 216 ? 151.721 99.395  125.873 1.00 115.17 ? 216 LEU A N   1 
ATOM 1245 C CA  . LEU A 1 216 ? 151.975 100.629 125.135 1.00 117.04 ? 216 LEU A CA  1 
ATOM 1246 C C   . LEU A 1 216 ? 153.160 100.472 124.188 1.00 121.30 ? 216 LEU A C   1 
ATOM 1247 O O   . LEU A 1 216 ? 153.099 100.897 123.026 1.00 127.31 ? 216 LEU A O   1 
ATOM 1248 C CB  . LEU A 1 216 ? 152.205 101.787 126.103 1.00 117.50 ? 216 LEU A CB  1 
ATOM 1249 C CG  . LEU A 1 216 ? 150.949 102.512 126.592 1.00 117.60 ? 216 LEU A CG  1 
ATOM 1250 C CD1 . LEU A 1 216 ? 151.284 103.919 127.045 1.00 121.71 ? 216 LEU A CD1 1 
ATOM 1251 C CD2 . LEU A 1 216 ? 149.882 102.544 125.514 1.00 121.35 ? 216 LEU A CD2 1 
ATOM 1252 N N   . LEU A 1 217 ? 154.238 99.842  124.660 1.00 125.59 ? 217 LEU A N   1 
ATOM 1253 C CA  . LEU A 1 217 ? 155.398 99.614  123.803 1.00 124.74 ? 217 LEU A CA  1 
ATOM 1254 C C   . LEU A 1 217 ? 155.059 98.689  122.640 1.00 130.54 ? 217 LEU A C   1 
ATOM 1255 O O   . LEU A 1 217 ? 155.503 98.914  121.505 1.00 134.18 ? 217 LEU A O   1 
ATOM 1256 C CB  . LEU A 1 217 ? 156.549 99.040  124.623 1.00 121.81 ? 217 LEU A CB  1 
ATOM 1257 C CG  . LEU A 1 217 ? 157.565 100.041 125.173 1.00 129.86 ? 217 LEU A CG  1 
ATOM 1258 C CD1 . LEU A 1 217 ? 158.849 99.331  125.556 1.00 133.70 ? 217 LEU A CD1 1 
ATOM 1259 C CD2 . LEU A 1 217 ? 157.841 101.136 124.162 1.00 135.75 ? 217 LEU A CD2 1 
ATOM 1260 N N   . ILE A 1 218 ? 154.279 97.638  122.905 1.00 123.93 ? 218 ILE A N   1 
ATOM 1261 C CA  . ILE A 1 218 ? 153.909 96.695  121.853 1.00 119.05 ? 218 ILE A CA  1 
ATOM 1262 C C   . ILE A 1 218 ? 153.083 97.387  120.778 1.00 123.26 ? 218 ILE A C   1 
ATOM 1263 O O   . ILE A 1 218 ? 153.304 97.189  119.577 1.00 131.48 ? 218 ILE A O   1 
ATOM 1264 C CB  . ILE A 1 218 ? 153.165 95.491  122.461 1.00 116.10 ? 218 ILE A CB  1 
ATOM 1265 C CG1 . ILE A 1 218 ? 154.165 94.493  123.041 1.00 129.15 ? 218 ILE A CG1 1 
ATOM 1266 C CG2 . ILE A 1 218 ? 152.282 94.814  121.427 1.00 118.49 ? 218 ILE A CG2 1 
ATOM 1267 C CD1 . ILE A 1 218 ? 155.129 93.939  122.019 1.00 131.03 ? 218 ILE A CD1 1 
ATOM 1268 N N   . PHE A 1 219 ? 152.128 98.223  121.187 1.00 126.33 ? 219 PHE A N   1 
ATOM 1269 C CA  . PHE A 1 219 ? 151.306 98.921  120.205 1.00 124.83 ? 219 PHE A CA  1 
ATOM 1270 C C   . PHE A 1 219 ? 152.104 99.968  119.438 1.00 128.04 ? 219 PHE A C   1 
ATOM 1271 O O   . PHE A 1 219 ? 151.847 100.189 118.249 1.00 131.47 ? 219 PHE A O   1 
ATOM 1272 C CB  . PHE A 1 219 ? 150.099 99.555  120.887 1.00 121.72 ? 219 PHE A CB  1 
ATOM 1273 C CG  . PHE A 1 219 ? 149.127 98.557  121.444 1.00 127.89 ? 219 PHE A CG  1 
ATOM 1274 C CD1 . PHE A 1 219 ? 149.092 97.261  120.963 1.00 130.41 ? 219 PHE A CD1 1 
ATOM 1275 C CD2 . PHE A 1 219 ? 148.251 98.917  122.452 1.00 135.40 ? 219 PHE A CD2 1 
ATOM 1276 C CE1 . PHE A 1 219 ? 148.201 96.343  121.475 1.00 133.79 ? 219 PHE A CE1 1 
ATOM 1277 C CE2 . PHE A 1 219 ? 147.358 98.002  122.968 1.00 136.34 ? 219 PHE A CE2 1 
ATOM 1278 C CZ  . PHE A 1 219 ? 147.334 96.712  122.480 1.00 134.37 ? 219 PHE A CZ  1 
ATOM 1279 N N   . THR A 1 220 ? 153.074 100.617 120.087 1.00 137.75 ? 220 THR A N   1 
ATOM 1280 C CA  . THR A 1 220 ? 153.959 101.522 119.358 1.00 138.21 ? 220 THR A CA  1 
ATOM 1281 C C   . THR A 1 220 ? 154.763 100.768 118.303 1.00 139.25 ? 220 THR A C   1 
ATOM 1282 O O   . THR A 1 220 ? 154.912 101.239 117.167 1.00 147.36 ? 220 THR A O   1 
ATOM 1283 C CB  . THR A 1 220 ? 154.888 102.245 120.336 1.00 144.20 ? 220 THR A CB  1 
ATOM 1284 O OG1 . THR A 1 220 ? 154.153 103.259 121.030 1.00 150.29 ? 220 THR A OG1 1 
ATOM 1285 C CG2 . THR A 1 220 ? 156.055 102.889 119.607 1.00 143.63 ? 220 THR A CG2 1 
ATOM 1286 N N   . SER A 1 221 ? 155.272 99.586  118.656 1.00 133.22 ? 221 SER A N   1 
ATOM 1287 C CA  . SER A 1 221 ? 155.989 98.770  117.680 1.00 139.45 ? 221 SER A CA  1 
ATOM 1288 C C   . SER A 1 221 ? 155.076 98.346  116.536 1.00 139.21 ? 221 SER A C   1 
ATOM 1289 O O   . SER A 1 221 ? 155.503 98.297  115.374 1.00 141.74 ? 221 SER A O   1 
ATOM 1290 C CB  . SER A 1 221 ? 156.592 97.545  118.366 1.00 143.53 ? 221 SER A CB  1 
ATOM 1291 O OG  . SER A 1 221 ? 156.873 96.525  117.426 1.00 149.02 ? 221 SER A OG  1 
ATOM 1292 N N   . ALA A 1 222 ? 153.822 98.020  116.846 1.00 119.83 ? 222 ALA A N   1 
ATOM 1293 C CA  . ALA A 1 222 ? 152.869 97.658  115.801 1.00 120.82 ? 222 ALA A CA  1 
ATOM 1294 C C   . ALA A 1 222 ? 152.610 98.826  114.859 1.00 124.37 ? 222 ALA A C   1 
ATOM 1295 O O   . ALA A 1 222 ? 152.516 98.639  113.640 1.00 134.86 ? 222 ALA A O   1 
ATOM 1296 C CB  . ALA A 1 222 ? 151.563 97.176  116.427 1.00 128.93 ? 222 ALA A CB  1 
ATOM 1297 N N   . THR A 1 223 ? 152.482 100.036 115.409 1.00 107.42 ? 223 THR A N   1 
ATOM 1298 C CA  . THR A 1 223 ? 152.318 101.220 114.572 1.00 106.35 ? 223 THR A CA  1 
ATOM 1299 C C   . THR A 1 223 ? 153.532 101.425 113.675 1.00 100.80 ? 223 THR A C   1 
ATOM 1300 O O   . THR A 1 223 ? 153.392 101.731 112.482 1.00 107.52 ? 223 THR A O   1 
ATOM 1301 C CB  . THR A 1 223 ? 152.078 102.449 115.450 1.00 111.04 ? 223 THR A CB  1 
ATOM 1302 O OG1 . THR A 1 223 ? 150.698 102.503 115.829 1.00 121.99 ? 223 THR A OG1 1 
ATOM 1303 C CG2 . THR A 1 223 ? 152.440 103.731 114.718 1.00 102.27 ? 223 THR A CG2 1 
ATOM 1304 N N   . TYR A 1 224 ? 154.733 101.250 114.234 1.00 127.56 ? 224 TYR A N   1 
ATOM 1305 C CA  . TYR A 1 224 ? 155.956 101.324 113.441 1.00 128.37 ? 224 TYR A CA  1 
ATOM 1306 C C   . TYR A 1 224 ? 155.916 100.347 112.275 1.00 134.45 ? 224 TYR A C   1 
ATOM 1307 O O   . TYR A 1 224 ? 156.199 100.717 111.129 1.00 141.22 ? 224 TYR A O   1 
ATOM 1308 C CB  . TYR A 1 224 ? 157.168 101.017 114.316 1.00 135.62 ? 224 TYR A CB  1 
ATOM 1309 C CG  . TYR A 1 224 ? 157.837 102.220 114.922 1.00 139.65 ? 224 TYR A CG  1 
ATOM 1310 C CD1 . TYR A 1 224 ? 157.154 103.415 115.084 1.00 139.81 ? 224 TYR A CD1 1 
ATOM 1311 C CD2 . TYR A 1 224 ? 159.155 102.153 115.335 1.00 142.21 ? 224 TYR A CD2 1 
ATOM 1312 C CE1 . TYR A 1 224 ? 157.771 104.511 115.641 1.00 140.66 ? 224 TYR A CE1 1 
ATOM 1313 C CE2 . TYR A 1 224 ? 159.781 103.238 115.892 1.00 144.38 ? 224 TYR A CE2 1 
ATOM 1314 C CZ  . TYR A 1 224 ? 159.086 104.413 116.043 1.00 142.83 ? 224 TYR A CZ  1 
ATOM 1315 O OH  . TYR A 1 224 ? 159.720 105.491 116.598 1.00 140.06 ? 224 TYR A OH  1 
ATOM 1316 N N   . LEU A 1 225 ? 155.579 99.089  112.559 1.00 125.52 ? 225 LEU A N   1 
ATOM 1317 C CA  . LEU A 1 225 ? 155.571 98.070  111.515 1.00 118.82 ? 225 LEU A CA  1 
ATOM 1318 C C   . LEU A 1 225 ? 154.542 98.389  110.443 1.00 119.58 ? 225 LEU A C   1 
ATOM 1319 O O   . LEU A 1 225 ? 154.838 98.303  109.245 1.00 124.30 ? 225 LEU A O   1 
ATOM 1320 C CB  . LEU A 1 225 ? 155.298 96.698  112.128 1.00 115.72 ? 225 LEU A CB  1 
ATOM 1321 C CG  . LEU A 1 225 ? 156.473 95.721  112.165 1.00 123.84 ? 225 LEU A CG  1 
ATOM 1322 C CD1 . LEU A 1 225 ? 155.968 94.295  112.296 1.00 132.26 ? 225 LEU A CD1 1 
ATOM 1323 C CD2 . LEU A 1 225 ? 157.345 95.868  110.929 1.00 122.38 ? 225 LEU A CD2 1 
ATOM 1324 N N   . TYR A 1 226 ? 153.338 98.790  110.855 1.00 118.12 ? 226 TYR A N   1 
ATOM 1325 C CA  . TYR A 1 226 ? 152.279 99.106  109.901 1.00 119.03 ? 226 TYR A CA  1 
ATOM 1326 C C   . TYR A 1 226 ? 152.686 100.254 108.988 1.00 111.06 ? 226 TYR A C   1 
ATOM 1327 O O   . TYR A 1 226 ? 152.583 100.151 107.756 1.00 121.58 ? 226 TYR A O   1 
ATOM 1328 C CB  . TYR A 1 226 ? 150.998 99.441  110.663 1.00 120.01 ? 226 TYR A CB  1 
ATOM 1329 C CG  . TYR A 1 226 ? 149.932 100.142 109.857 1.00 111.98 ? 226 TYR A CG  1 
ATOM 1330 C CD1 . TYR A 1 226 ? 149.273 99.493  108.826 1.00 115.68 ? 226 TYR A CD1 1 
ATOM 1331 C CD2 . TYR A 1 226 ? 149.570 101.448 110.143 1.00 111.46 ? 226 TYR A CD2 1 
ATOM 1332 C CE1 . TYR A 1 226 ? 148.292 100.128 108.097 1.00 117.04 ? 226 TYR A CE1 1 
ATOM 1333 C CE2 . TYR A 1 226 ? 148.591 102.091 109.418 1.00 119.06 ? 226 TYR A CE2 1 
ATOM 1334 C CZ  . TYR A 1 226 ? 147.956 101.427 108.395 1.00 120.71 ? 226 TYR A CZ  1 
ATOM 1335 O OH  . TYR A 1 226 ? 146.978 102.065 107.670 1.00 126.02 ? 226 TYR A OH  1 
ATOM 1336 N N   . LEU A 1 227 ? 153.179 101.347 109.575 1.00 113.17 ? 227 LEU A N   1 
ATOM 1337 C CA  . LEU A 1 227 ? 153.571 102.499 108.772 1.00 116.99 ? 227 LEU A CA  1 
ATOM 1338 C C   . LEU A 1 227 ? 154.715 102.151 107.833 1.00 120.04 ? 227 LEU A C   1 
ATOM 1339 O O   . LEU A 1 227 ? 154.604 102.328 106.616 1.00 131.29 ? 227 LEU A O   1 
ATOM 1340 C CB  . LEU A 1 227 ? 153.955 103.665 109.681 1.00 117.74 ? 227 LEU A CB  1 
ATOM 1341 C CG  . LEU A 1 227 ? 152.785 104.524 110.160 1.00 120.77 ? 227 LEU A CG  1 
ATOM 1342 C CD1 . LEU A 1 227 ? 153.280 105.756 110.884 1.00 121.07 ? 227 LEU A CD1 1 
ATOM 1343 C CD2 . LEU A 1 227 ? 151.902 104.912 108.993 1.00 122.81 ? 227 LEU A CD2 1 
ATOM 1344 N N   . GLY A 1 228 ? 155.798 101.589 108.371 1.00 125.41 ? 228 GLY A N   1 
ATOM 1345 C CA  . GLY A 1 228 ? 156.957 101.290 107.556 1.00 127.94 ? 228 GLY A CA  1 
ATOM 1346 C C   . GLY A 1 228 ? 156.754 100.181 106.549 1.00 125.09 ? 228 GLY A C   1 
ATOM 1347 O O   . GLY A 1 228 ? 157.573 100.049 105.633 1.00 126.75 ? 228 GLY A O   1 
ATOM 1348 N N   . HIS A 1 229 ? 155.693 99.387  106.687 1.00 127.79 ? 229 HIS A N   1 
ATOM 1349 C CA  . HIS A 1 229 ? 155.425 98.345  105.712 1.00 128.57 ? 229 HIS A CA  1 
ATOM 1350 C C   . HIS A 1 229 ? 154.389 98.736  104.673 1.00 131.45 ? 229 HIS A C   1 
ATOM 1351 O O   . HIS A 1 229 ? 154.378 98.143  103.589 1.00 132.90 ? 229 HIS A O   1 
ATOM 1352 C CB  . HIS A 1 229 ? 154.965 97.064  106.416 1.00 134.90 ? 229 HIS A CB  1 
ATOM 1353 C CG  . HIS A 1 229 ? 155.322 95.812  105.681 1.00 142.77 ? 229 HIS A CG  1 
ATOM 1354 N ND1 . HIS A 1 229 ? 155.005 95.615  104.354 1.00 146.91 ? 229 HIS A ND1 1 
ATOM 1355 C CD2 . HIS A 1 229 ? 155.974 94.697  106.082 1.00 141.41 ? 229 HIS A CD2 1 
ATOM 1356 C CE1 . HIS A 1 229 ? 155.443 94.429  103.972 1.00 146.72 ? 229 HIS A CE1 1 
ATOM 1357 N NE2 . HIS A 1 229 ? 156.035 93.852  105.002 1.00 145.69 ? 229 HIS A NE2 1 
ATOM 1358 N N   . PHE A 1 230 ? 153.522 99.707  104.959 1.00 138.43 ? 230 PHE A N   1 
ATOM 1359 C CA  . PHE A 1 230 ? 152.506 100.090 103.986 1.00 136.62 ? 230 PHE A CA  1 
ATOM 1360 C C   . PHE A 1 230 ? 152.684 101.495 103.429 1.00 136.67 ? 230 PHE A C   1 
ATOM 1361 O O   . PHE A 1 230 ? 152.643 101.676 102.210 1.00 144.13 ? 230 PHE A O   1 
ATOM 1362 C CB  . PHE A 1 230 ? 151.110 99.940  104.605 1.00 131.68 ? 230 PHE A CB  1 
ATOM 1363 C CG  . PHE A 1 230 ? 150.693 98.513  104.796 1.00 135.32 ? 230 PHE A CG  1 
ATOM 1364 C CD1 . PHE A 1 230 ? 151.293 97.501  104.067 1.00 139.90 ? 230 PHE A CD1 1 
ATOM 1365 C CD2 . PHE A 1 230 ? 149.704 98.180  105.699 1.00 133.17 ? 230 PHE A CD2 1 
ATOM 1366 C CE1 . PHE A 1 230 ? 150.915 96.187  104.239 1.00 140.36 ? 230 PHE A CE1 1 
ATOM 1367 C CE2 . PHE A 1 230 ? 149.321 96.868  105.875 1.00 139.72 ? 230 PHE A CE2 1 
ATOM 1368 C CZ  . PHE A 1 230 ? 149.927 95.871  105.144 1.00 143.72 ? 230 PHE A CZ  1 
ATOM 1369 N N   . HIS A 1 231 ? 152.880 102.502 104.282 1.00 116.90 ? 231 HIS A N   1 
ATOM 1370 C CA  . HIS A 1 231 ? 152.903 103.874 103.791 1.00 109.36 ? 231 HIS A CA  1 
ATOM 1371 C C   . HIS A 1 231 ? 154.174 104.205 103.025 1.00 113.71 ? 231 HIS A C   1 
ATOM 1372 O O   . HIS A 1 231 ? 154.197 105.195 102.291 1.00 128.42 ? 231 HIS A O   1 
ATOM 1373 C CB  . HIS A 1 231 ? 152.746 104.848 104.956 1.00 112.01 ? 231 HIS A CB  1 
ATOM 1374 C CG  . HIS A 1 231 ? 151.341 104.978 105.449 1.00 113.93 ? 231 HIS A CG  1 
ATOM 1375 N ND1 . HIS A 1 231 ? 150.868 106.122 106.052 1.00 119.73 ? 231 HIS A ND1 1 
ATOM 1376 C CD2 . HIS A 1 231 ? 150.305 104.108 105.427 1.00 119.85 ? 231 HIS A CD2 1 
ATOM 1377 C CE1 . HIS A 1 231 ? 149.601 105.950 106.384 1.00 123.42 ? 231 HIS A CE1 1 
ATOM 1378 N NE2 . HIS A 1 231 ? 149.234 104.737 106.015 1.00 123.21 ? 231 HIS A NE2 1 
ATOM 1379 N N   . LEU A 1 232 ? 155.230 103.406 103.179 1.00 113.01 ? 232 LEU A N   1 
ATOM 1380 C CA  . LEU A 1 232 ? 156.505 103.754 102.563 1.00 115.67 ? 232 LEU A CA  1 
ATOM 1381 C C   . LEU A 1 232 ? 156.470 103.572 101.051 1.00 124.87 ? 232 LEU A C   1 
ATOM 1382 O O   . LEU A 1 232 ? 157.094 104.344 100.315 1.00 132.10 ? 232 LEU A O   1 
ATOM 1383 C CB  . LEU A 1 232 ? 157.626 102.917 103.174 1.00 120.34 ? 232 LEU A CB  1 
ATOM 1384 C CG  . LEU A 1 232 ? 159.040 103.382 102.831 1.00 129.17 ? 232 LEU A CG  1 
ATOM 1385 C CD1 . LEU A 1 232 ? 159.441 104.547 103.719 1.00 128.64 ? 232 LEU A CD1 1 
ATOM 1386 C CD2 . LEU A 1 232 ? 160.027 102.237 102.962 1.00 132.42 ? 232 LEU A CD2 1 
ATOM 1387 N N   . ASP A 1 233 ? 155.751 102.564 100.567 1.00 144.14 ? 233 ASP A N   1 
ATOM 1388 C CA  . ASP A 1 233 ? 155.769 102.243 99.146  1.00 144.60 ? 233 ASP A CA  1 
ATOM 1389 C C   . ASP A 1 233 ? 154.843 103.121 98.315  1.00 141.28 ? 233 ASP A C   1 
ATOM 1390 O O   . ASP A 1 233 ? 154.855 103.007 97.087  1.00 141.78 ? 233 ASP A O   1 
ATOM 1391 C CB  . ASP A 1 233 ? 155.403 100.773 98.937  1.00 151.32 ? 233 ASP A CB  1 
ATOM 1392 C CG  . ASP A 1 233 ? 156.605 99.859  99.039  1.00 158.37 ? 233 ASP A CG  1 
ATOM 1393 O OD1 . ASP A 1 233 ? 157.742 100.375 99.054  1.00 156.24 ? 233 ASP A OD1 1 
ATOM 1394 O OD2 . ASP A 1 233 ? 156.414 98.627  99.102  1.00 158.87 ? 233 ASP A OD2 1 
ATOM 1395 N N   . VAL A 1 234 ? 154.047 103.984 98.942  1.00 129.93 ? 234 VAL A N   1 
ATOM 1396 C CA  . VAL A 1 234 ? 153.144 104.870 98.219  1.00 130.84 ? 234 VAL A CA  1 
ATOM 1397 C C   . VAL A 1 234 ? 153.540 106.328 98.337  1.00 138.48 ? 234 VAL A C   1 
ATOM 1398 O O   . VAL A 1 234 ? 152.799 107.200 97.863  1.00 143.41 ? 234 VAL A O   1 
ATOM 1399 C CB  . VAL A 1 234 ? 151.685 104.672 98.669  1.00 131.82 ? 234 VAL A CB  1 
ATOM 1400 C CG1 . VAL A 1 234 ? 151.290 103.217 98.527  1.00 135.80 ? 234 VAL A CG1 1 
ATOM 1401 C CG2 . VAL A 1 234 ? 151.510 105.131 100.098 1.00 137.39 ? 234 VAL A CG2 1 
ATOM 1402 N N   . PHE A 1 235 ? 154.677 106.628 98.957  1.00 127.25 ? 235 PHE A N   1 
ATOM 1403 C CA  . PHE A 1 235 ? 155.203 107.984 98.936  1.00 120.37 ? 235 PHE A CA  1 
ATOM 1404 C C   . PHE A 1 235 ? 155.623 108.368 97.523  1.00 127.48 ? 235 PHE A C   1 
ATOM 1405 O O   . PHE A 1 235 ? 155.985 107.516 96.708  1.00 135.60 ? 235 PHE A O   1 
ATOM 1406 C CB  . PHE A 1 235 ? 156.397 108.118 99.878  1.00 119.21 ? 235 PHE A CB  1 
ATOM 1407 C CG  . PHE A 1 235 ? 156.092 108.851 101.148 1.00 118.14 ? 235 PHE A CG  1 
ATOM 1408 C CD1 . PHE A 1 235 ? 155.034 108.469 101.949 1.00 123.94 ? 235 PHE A CD1 1 
ATOM 1409 C CD2 . PHE A 1 235 ? 156.872 109.921 101.542 1.00 117.78 ? 235 PHE A CD2 1 
ATOM 1410 C CE1 . PHE A 1 235 ? 154.760 109.145 103.119 1.00 124.60 ? 235 PHE A CE1 1 
ATOM 1411 C CE2 . PHE A 1 235 ? 156.603 110.601 102.709 1.00 118.32 ? 235 PHE A CE2 1 
ATOM 1412 C CZ  . PHE A 1 235 ? 155.545 110.212 103.499 1.00 121.59 ? 235 PHE A CZ  1 
ATOM 1413 N N   . PHE A 1 236 ? 155.572 109.672 97.245  1.00 128.76 ? 236 PHE A N   1 
ATOM 1414 C CA  . PHE A 1 236 ? 155.956 110.237 95.949  1.00 133.60 ? 236 PHE A CA  1 
ATOM 1415 C C   . PHE A 1 236 ? 155.170 109.618 94.798  1.00 135.86 ? 236 PHE A C   1 
ATOM 1416 O O   . PHE A 1 236 ? 155.671 109.508 93.677  1.00 137.94 ? 236 PHE A O   1 
ATOM 1417 C CB  . PHE A 1 236 ? 157.462 110.105 95.699  1.00 135.81 ? 236 PHE A CB  1 
ATOM 1418 C CG  . PHE A 1 236 ? 158.288 110.049 96.952  1.00 135.45 ? 236 PHE A CG  1 
ATOM 1419 C CD1 . PHE A 1 236 ? 158.416 111.165 97.762  1.00 139.43 ? 236 PHE A CD1 1 
ATOM 1420 C CD2 . PHE A 1 236 ? 158.942 108.885 97.316  1.00 135.04 ? 236 PHE A CD2 1 
ATOM 1421 C CE1 . PHE A 1 236 ? 159.176 111.117 98.913  1.00 141.52 ? 236 PHE A CE1 1 
ATOM 1422 C CE2 . PHE A 1 236 ? 159.703 108.832 98.464  1.00 136.14 ? 236 PHE A CE2 1 
ATOM 1423 C CZ  . PHE A 1 236 ? 159.820 109.949 99.264  1.00 137.97 ? 236 PHE A CZ  1 
ATOM 1424 N N   . GLN A 1 237 ? 153.935 109.206 95.064  1.00 129.46 ? 237 GLN A N   1 
ATOM 1425 C CA  . GLN A 1 237 ? 153.040 108.654 94.051  1.00 128.14 ? 237 GLN A CA  1 
ATOM 1426 C C   . GLN A 1 237 ? 151.759 109.477 94.103  1.00 134.99 ? 237 GLN A C   1 
ATOM 1427 O O   . GLN A 1 237 ? 150.900 109.251 94.959  1.00 134.50 ? 237 GLN A O   1 
ATOM 1428 C CB  . GLN A 1 237 ? 152.773 107.172 94.296  1.00 126.54 ? 237 GLN A CB  1 
ATOM 1429 C CG  . GLN A 1 237 ? 151.722 106.567 93.384  1.00 127.80 ? 237 GLN A CG  1 
ATOM 1430 C CD  . GLN A 1 237 ? 152.326 105.744 92.268  1.00 131.69 ? 237 GLN A CD  1 
ATOM 1431 O OE1 . GLN A 1 237 ? 153.371 106.091 91.721  1.00 135.13 ? 237 GLN A OE1 1 
ATOM 1432 N NE2 . GLN A 1 237 ? 151.670 104.642 91.924  1.00 131.19 ? 237 GLN A NE2 1 
ATOM 1433 N N   . GLU A 1 238 ? 151.638 110.441 93.193  1.00 143.57 ? 238 GLU A N   1 
ATOM 1434 C CA  . GLU A 1 238 ? 150.527 111.379 93.217  1.00 139.76 ? 238 GLU A CA  1 
ATOM 1435 C C   . GLU A 1 238 ? 149.497 111.123 92.129  1.00 139.02 ? 238 GLU A C   1 
ATOM 1436 O O   . GLU A 1 238 ? 148.413 111.713 92.179  1.00 140.97 ? 238 GLU A O   1 
ATOM 1437 C CB  . GLU A 1 238 ? 151.035 112.827 93.094  1.00 139.30 ? 238 GLU A CB  1 
ATOM 1438 C CG  . GLU A 1 238 ? 151.799 113.204 91.808  1.00 143.36 ? 238 GLU A CG  1 
ATOM 1439 C CD  . GLU A 1 238 ? 153.135 112.493 91.595  1.00 147.98 ? 238 GLU A CD  1 
ATOM 1440 O OE1 . GLU A 1 238 ? 153.866 112.899 90.668  1.00 148.06 ? 238 GLU A OE1 1 
ATOM 1441 O OE2 . GLU A 1 238 ? 153.478 111.557 92.347  1.00 148.76 ? 238 GLU A OE2 1 
ATOM 1442 N N   . GLU A 1 239 ? 149.795 110.265 91.158  1.00 132.09 ? 239 GLU A N   1 
ATOM 1443 C CA  . GLU A 1 239 ? 148.855 110.019 90.077  1.00 133.91 ? 239 GLU A CA  1 
ATOM 1444 C C   . GLU A 1 239 ? 148.994 108.582 89.601  1.00 134.63 ? 239 GLU A C   1 
ATOM 1445 O O   . GLU A 1 239 ? 150.038 107.947 89.767  1.00 137.02 ? 239 GLU A O   1 
ATOM 1446 C CB  . GLU A 1 239 ? 149.068 111.013 88.931  1.00 135.02 ? 239 GLU A CB  1 
ATOM 1447 C CG  . GLU A 1 239 ? 150.194 110.667 87.987  1.00 133.17 ? 239 GLU A CG  1 
ATOM 1448 C CD  . GLU A 1 239 ? 150.434 111.759 86.965  1.00 142.13 ? 239 GLU A CD  1 
ATOM 1449 O OE1 . GLU A 1 239 ? 151.050 111.476 85.919  1.00 142.78 ? 239 GLU A OE1 1 
ATOM 1450 O OE2 . GLU A 1 239 ? 150.006 112.905 87.209  1.00 142.71 ? 239 GLU A OE2 1 
ATOM 1451 N N   . PHE A 1 240 ? 147.913 108.074 89.013  1.00 122.30 ? 240 PHE A N   1 
ATOM 1452 C CA  . PHE A 1 240 ? 147.855 106.691 88.569  1.00 119.64 ? 240 PHE A CA  1 
ATOM 1453 C C   . PHE A 1 240 ? 146.871 106.566 87.416  1.00 122.96 ? 240 PHE A C   1 
ATOM 1454 O O   . PHE A 1 240 ? 145.985 107.405 87.231  1.00 135.91 ? 240 PHE A O   1 
ATOM 1455 C CB  . PHE A 1 240 ? 147.455 105.748 89.710  1.00 119.50 ? 240 PHE A CB  1 
ATOM 1456 C CG  . PHE A 1 240 ? 146.133 106.081 90.340  1.00 115.77 ? 240 PHE A CG  1 
ATOM 1457 C CD1 . PHE A 1 240 ? 146.058 106.994 91.374  1.00 120.06 ? 240 PHE A CD1 1 
ATOM 1458 C CD2 . PHE A 1 240 ? 144.970 105.467 89.912  1.00 118.86 ? 240 PHE A CD2 1 
ATOM 1459 C CE1 . PHE A 1 240 ? 144.848 107.300 91.957  1.00 123.16 ? 240 PHE A CE1 1 
ATOM 1460 C CE2 . PHE A 1 240 ? 143.757 105.771 90.493  1.00 120.43 ? 240 PHE A CE2 1 
ATOM 1461 C CZ  . PHE A 1 240 ? 143.697 106.688 91.518  1.00 121.70 ? 240 PHE A CZ  1 
ATOM 1462 N N   . SER A 1 241 ? 147.025 105.490 86.654  1.00 119.28 ? 241 SER A N   1 
ATOM 1463 C CA  . SER A 1 241 ? 146.183 105.221 85.492  1.00 120.60 ? 241 SER A CA  1 
ATOM 1464 C C   . SER A 1 241 ? 145.059 104.287 85.923  1.00 126.33 ? 241 SER A C   1 
ATOM 1465 O O   . SER A 1 241 ? 145.250 103.073 86.023  1.00 134.75 ? 241 SER A O   1 
ATOM 1466 C CB  . SER A 1 241 ? 147.010 104.621 84.360  1.00 122.68 ? 241 SER A CB  1 
ATOM 1467 O OG  . SER A 1 241 ? 146.200 104.345 83.235  1.00 135.95 ? 241 SER A OG  1 
ATOM 1468 N N   . CYS A 1 242 ? 143.885 104.855 86.178  1.00 123.29 ? 242 CYS A N   1 
ATOM 1469 C CA  . CYS A 1 242 ? 142.720 104.081 86.574  1.00 123.57 ? 242 CYS A CA  1 
ATOM 1470 C C   . CYS A 1 242 ? 141.938 103.645 85.343  1.00 126.08 ? 242 CYS A C   1 
ATOM 1471 O O   . CYS A 1 242 ? 141.970 104.300 84.298  1.00 127.95 ? 242 CYS A O   1 
ATOM 1472 C CB  . CYS A 1 242 ? 141.826 104.901 87.506  1.00 128.45 ? 242 CYS A CB  1 
ATOM 1473 S SG  . CYS A 1 242 ? 140.105 104.367 87.592  1.00 136.82 ? 242 CYS A SG  1 
ATOM 1474 N N   . SER A 1 243 ? 141.236 102.523 85.474  1.00 130.33 ? 243 SER A N   1 
ATOM 1475 C CA  . SER A 1 243 ? 140.458 101.958 84.383  1.00 133.49 ? 243 SER A CA  1 
ATOM 1476 C C   . SER A 1 243 ? 139.067 101.596 84.878  1.00 133.99 ? 243 SER A C   1 
ATOM 1477 O O   . SER A 1 243 ? 138.876 101.256 86.049  1.00 137.36 ? 243 SER A O   1 
ATOM 1478 C CB  . SER A 1 243 ? 141.135 100.719 83.793  1.00 134.98 ? 243 SER A CB  1 
ATOM 1479 O OG  . SER A 1 243 ? 140.366 100.181 82.734  1.00 138.52 ? 243 SER A OG  1 
ATOM 1480 N N   . ILE A 1 244 ? 138.094 101.672 83.973  1.00 116.42 ? 244 ILE A N   1 
ATOM 1481 C CA  . ILE A 1 244 ? 136.710 101.363 84.313  1.00 116.95 ? 244 ILE A CA  1 
ATOM 1482 C C   . ILE A 1 244 ? 136.150 100.357 83.317  1.00 122.54 ? 244 ILE A C   1 
ATOM 1483 O O   . ILE A 1 244 ? 135.062 99.808  83.519  1.00 128.75 ? 244 ILE A O   1 
ATOM 1484 C CB  . ILE A 1 244 ? 135.844 102.633 84.348  1.00 113.35 ? 244 ILE A CB  1 
ATOM 1485 C CG1 . ILE A 1 244 ? 135.937 103.375 83.017  1.00 119.19 ? 244 ILE A CG1 1 
ATOM 1486 C CG2 . ILE A 1 244 ? 136.269 103.538 85.487  1.00 112.99 ? 244 ILE A CG2 1 
ATOM 1487 C CD1 . ILE A 1 244 ? 135.011 104.561 82.926  1.00 123.81 ? 244 ILE A CD1 1 
ATOM 1488 N N   . LYS A 1 245 ? 136.884 100.108 82.239  1.00 137.90 ? 245 LYS A N   1 
ATOM 1489 C CA  . LYS A 1 245 ? 136.437 99.185  81.196  1.00 139.91 ? 245 LYS A CA  1 
ATOM 1490 C C   . LYS A 1 245 ? 136.783 97.738  81.535  1.00 146.63 ? 245 LYS A C   1 
ATOM 1491 O O   . LYS A 1 245 ? 137.431 97.036  80.761  1.00 151.23 ? 245 LYS A O   1 
ATOM 1492 C CB  . LYS A 1 245 ? 137.036 99.588  79.856  1.00 137.43 ? 245 LYS A CB  1 
ATOM 1493 C CG  . LYS A 1 245 ? 136.085 100.355 78.958  1.00 138.78 ? 245 LYS A CG  1 
ATOM 1494 C CD  . LYS A 1 245 ? 136.745 100.724 77.640  1.00 142.22 ? 245 LYS A CD  1 
ATOM 1495 C CE  . LYS A 1 245 ? 137.309 99.503  76.941  1.00 144.21 ? 245 LYS A CE  1 
ATOM 1496 N NZ  . LYS A 1 245 ? 137.944 99.857  75.643  1.00 147.88 ? 245 LYS A NZ  1 
ATOM 1497 N N   . THR A 1 246 ? 136.348 97.280  82.704  1.00 142.22 ? 246 THR A N   1 
ATOM 1498 C CA  . THR A 1 246 ? 136.603 95.916  83.148  1.00 142.24 ? 246 THR A CA  1 
ATOM 1499 C C   . THR A 1 246 ? 135.353 95.056  83.191  1.00 144.46 ? 246 THR A C   1 
ATOM 1500 O O   . THR A 1 246 ? 135.381 93.913  82.726  1.00 144.50 ? 246 THR A O   1 
ATOM 1501 C CB  . THR A 1 246 ? 137.256 95.920  84.537  1.00 142.59 ? 246 THR A CB  1 
ATOM 1502 O OG1 . THR A 1 246 ? 136.247 96.083  85.540  1.00 145.17 ? 246 THR A OG1 1 
ATOM 1503 C CG2 . THR A 1 246 ? 138.261 97.052  84.650  1.00 138.30 ? 246 THR A CG2 1 
ATOM 1504 N N   . GLY A 1 247 ? 134.255 95.570  83.735  1.00 150.31 ? 247 GLY A N   1 
ATOM 1505 C CA  . GLY A 1 247 ? 133.033 94.798  83.838  1.00 149.80 ? 247 GLY A CA  1 
ATOM 1506 C C   . GLY A 1 247 ? 132.130 94.928  82.629  1.00 152.24 ? 247 GLY A C   1 
ATOM 1507 O O   . GLY A 1 247 ? 132.581 94.768  81.490  1.00 156.90 ? 247 GLY A O   1 
ATOM 1508 N N   . LEU A 1 248 ? 130.850 95.222  82.863  1.00 141.98 ? 248 LEU A N   1 
ATOM 1509 C CA  . LEU A 1 248 ? 129.892 95.344  81.771  1.00 146.26 ? 248 LEU A CA  1 
ATOM 1510 C C   . LEU A 1 248 ? 130.134 96.567  80.901  1.00 147.53 ? 248 LEU A C   1 
ATOM 1511 O O   . LEU A 1 248 ? 129.585 96.635  79.797  1.00 154.15 ? 248 LEU A O   1 
ATOM 1512 C CB  . LEU A 1 248 ? 128.457 95.382  82.303  1.00 148.02 ? 248 LEU A CB  1 
ATOM 1513 C CG  . LEU A 1 248 ? 128.019 94.458  83.445  1.00 151.93 ? 248 LEU A CG  1 
ATOM 1514 C CD1 . LEU A 1 248 ? 128.285 95.069  84.809  1.00 146.47 ? 248 LEU A CD1 1 
ATOM 1515 C CD2 . LEU A 1 248 ? 126.548 94.106  83.296  1.00 154.66 ? 248 LEU A CD2 1 
ATOM 1516 N N   . LEU A 1 249 ? 130.933 97.530  81.360  1.00 136.12 ? 249 LEU A N   1 
ATOM 1517 C CA  . LEU A 1 249 ? 131.211 98.709  80.552  1.00 140.19 ? 249 LEU A CA  1 
ATOM 1518 C C   . LEU A 1 249 ? 132.130 98.415  79.377  1.00 142.33 ? 249 LEU A C   1 
ATOM 1519 O O   . LEU A 1 249 ? 132.298 99.284  78.515  1.00 141.75 ? 249 LEU A O   1 
ATOM 1520 C CB  . LEU A 1 249 ? 131.823 99.809  81.416  1.00 138.83 ? 249 LEU A CB  1 
ATOM 1521 C CG  . LEU A 1 249 ? 130.892 100.984 81.701  1.00 135.08 ? 249 LEU A CG  1 
ATOM 1522 C CD1 . LEU A 1 249 ? 131.550 101.967 82.645  1.00 135.57 ? 249 LEU A CD1 1 
ATOM 1523 C CD2 . LEU A 1 249 ? 130.497 101.661 80.405  1.00 138.33 ? 249 LEU A CD2 1 
ATOM 1524 N N   . SER A 1 250 ? 132.724 97.226  79.319  1.00 145.73 ? 250 SER A N   1 
ATOM 1525 C CA  . SER A 1 250 ? 133.597 96.874  78.213  1.00 142.41 ? 250 SER A CA  1 
ATOM 1526 C C   . SER A 1 250 ? 132.789 96.702  76.929  1.00 145.09 ? 250 SER A C   1 
ATOM 1527 O O   . SER A 1 250 ? 131.555 96.757  76.924  1.00 148.16 ? 250 SER A O   1 
ATOM 1528 C CB  . SER A 1 250 ? 134.370 95.596  78.531  1.00 143.49 ? 250 SER A CB  1 
ATOM 1529 O OG  . SER A 1 250 ? 133.540 94.654  79.186  1.00 141.50 ? 250 SER A OG  1 
ATOM 1530 N N   . ASP A 1 251 ? 133.512 96.467  75.832  1.00 159.28 ? 251 ASP A N   1 
ATOM 1531 C CA  . ASP A 1 251 ? 132.935 96.384  74.490  1.00 162.46 ? 251 ASP A CA  1 
ATOM 1532 C C   . ASP A 1 251 ? 132.069 97.605  74.185  1.00 165.99 ? 251 ASP A C   1 
ATOM 1533 O O   . ASP A 1 251 ? 130.981 97.506  73.615  1.00 165.34 ? 251 ASP A O   1 
ATOM 1534 C CB  . ASP A 1 251 ? 132.143 95.086  74.294  1.00 163.69 ? 251 ASP A CB  1 
ATOM 1535 C CG  . ASP A 1 251 ? 132.818 93.879  74.924  1.00 166.31 ? 251 ASP A CG  1 
ATOM 1536 O OD1 . ASP A 1 251 ? 133.046 93.874  76.150  1.00 166.19 ? 251 ASP A OD1 1 
ATOM 1537 O OD2 . ASP A 1 251 ? 133.122 92.921  74.182  1.00 167.46 ? 251 ASP A OD2 1 
ATOM 1538 N N   . GLU A 1 252 ? 132.567 98.776  74.578  1.00 163.58 ? 252 GLU A N   1 
ATOM 1539 C CA  . GLU A 1 252 ? 131.844 100.023 74.356  1.00 160.67 ? 252 GLU A CA  1 
ATOM 1540 C C   . GLU A 1 252 ? 132.924 101.030 73.986  1.00 157.98 ? 252 GLU A C   1 
ATOM 1541 O O   . GLU A 1 252 ? 133.805 101.320 74.801  1.00 155.29 ? 252 GLU A O   1 
ATOM 1542 C CB  . GLU A 1 252 ? 131.048 100.417 75.611  1.00 156.16 ? 252 GLU A CB  1 
ATOM 1543 C CG  . GLU A 1 252 ? 130.134 101.672 75.590  1.00 159.19 ? 252 GLU A CG  1 
ATOM 1544 C CD  . GLU A 1 252 ? 130.729 102.966 75.072  1.00 163.86 ? 252 GLU A CD  1 
ATOM 1545 O OE1 . GLU A 1 252 ? 129.979 103.723 74.424  1.00 166.85 ? 252 GLU A OE1 1 
ATOM 1546 O OE2 . GLU A 1 252 ? 131.892 103.281 75.387  1.00 163.76 ? 252 GLU A OE2 1 
ATOM 1547 N N   . THR A 1 253 ? 132.866 101.547 72.760  1.00 149.44 ? 253 THR A N   1 
ATOM 1548 C CA  . THR A 1 253 ? 133.998 102.254 72.169  1.00 152.81 ? 253 THR A CA  1 
ATOM 1549 C C   . THR A 1 253 ? 134.168 103.689 72.654  1.00 151.82 ? 253 THR A C   1 
ATOM 1550 O O   . THR A 1 253 ? 135.256 104.248 72.483  1.00 150.54 ? 253 THR A O   1 
ATOM 1551 C CB  . THR A 1 253 ? 133.868 102.260 70.646  1.00 153.56 ? 253 THR A CB  1 
ATOM 1552 O OG1 . THR A 1 253 ? 134.868 103.117 70.083  1.00 154.07 ? 253 THR A OG1 1 
ATOM 1553 C CG2 . THR A 1 253 ? 132.493 102.757 70.236  1.00 148.07 ? 253 THR A CG2 1 
ATOM 1554 N N   . HIS A 1 254 ? 133.138 104.301 73.242  1.00 150.63 ? 254 HIS A N   1 
ATOM 1555 C CA  . HIS A 1 254 ? 133.214 105.724 73.569  1.00 148.18 ? 254 HIS A CA  1 
ATOM 1556 C C   . HIS A 1 254 ? 134.232 105.996 74.671  1.00 151.71 ? 254 HIS A C   1 
ATOM 1557 O O   . HIS A 1 254 ? 135.064 106.902 74.550  1.00 154.22 ? 254 HIS A O   1 
ATOM 1558 C CB  . HIS A 1 254 ? 131.835 106.242 73.974  1.00 149.58 ? 254 HIS A CB  1 
ATOM 1559 C CG  . HIS A 1 254 ? 131.811 107.696 74.323  1.00 154.15 ? 254 HIS A CG  1 
ATOM 1560 N ND1 . HIS A 1 254 ? 130.916 108.229 75.225  1.00 157.05 ? 254 HIS A ND1 1 
ATOM 1561 C CD2 . HIS A 1 254 ? 132.570 108.731 73.891  1.00 154.43 ? 254 HIS A CD2 1 
ATOM 1562 C CE1 . HIS A 1 254 ? 131.126 109.529 75.337  1.00 156.20 ? 254 HIS A CE1 1 
ATOM 1563 N NE2 . HIS A 1 254 ? 132.124 109.859 74.537  1.00 155.03 ? 254 HIS A NE2 1 
ATOM 1564 N N   . VAL A 1 255 ? 134.180 105.227 75.752  1.00 139.33 ? 255 VAL A N   1 
ATOM 1565 C CA  . VAL A 1 255 ? 135.071 105.432 76.892  1.00 135.44 ? 255 VAL A CA  1 
ATOM 1566 C C   . VAL A 1 255 ? 136.478 104.964 76.536  1.00 136.33 ? 255 VAL A C   1 
ATOM 1567 O O   . VAL A 1 255 ? 136.643 103.871 75.976  1.00 137.34 ? 255 VAL A O   1 
ATOM 1568 C CB  . VAL A 1 255 ? 134.529 104.721 78.142  1.00 133.01 ? 255 VAL A CB  1 
ATOM 1569 C CG1 . VAL A 1 255 ? 134.123 103.297 77.813  1.00 138.55 ? 255 VAL A CG1 1 
ATOM 1570 C CG2 . VAL A 1 255 ? 135.559 104.729 79.257  1.00 132.88 ? 255 VAL A CG2 1 
ATOM 1571 N N   . PRO A 1 256 ? 137.511 105.753 76.817  1.00 127.84 ? 256 PRO A N   1 
ATOM 1572 C CA  . PRO A 1 256 ? 138.879 105.322 76.515  1.00 127.40 ? 256 PRO A CA  1 
ATOM 1573 C C   . PRO A 1 256 ? 139.333 104.198 77.433  1.00 131.93 ? 256 PRO A C   1 
ATOM 1574 O O   . PRO A 1 256 ? 138.720 103.900 78.459  1.00 140.51 ? 256 PRO A O   1 
ATOM 1575 C CB  . PRO A 1 256 ? 139.702 106.591 76.747  1.00 125.99 ? 256 PRO A CB  1 
ATOM 1576 C CG  . PRO A 1 256 ? 138.917 107.344 77.759  1.00 129.11 ? 256 PRO A CG  1 
ATOM 1577 C CD  . PRO A 1 256 ? 137.484 107.118 77.367  1.00 127.96 ? 256 PRO A CD  1 
ATOM 1578 N N   . ASN A 1 257 ? 140.438 103.565 77.031  1.00 134.80 ? 257 ASN A N   1 
ATOM 1579 C CA  . ASN A 1 257 ? 140.925 102.389 77.744  1.00 139.25 ? 257 ASN A CA  1 
ATOM 1580 C C   . ASN A 1 257 ? 141.445 102.749 79.131  1.00 140.76 ? 257 ASN A C   1 
ATOM 1581 O O   . ASN A 1 257 ? 141.134 102.069 80.115  1.00 137.12 ? 257 ASN A O   1 
ATOM 1582 C CB  . ASN A 1 257 ? 142.015 101.698 76.925  1.00 137.91 ? 257 ASN A CB  1 
ATOM 1583 C CG  . ASN A 1 257 ? 141.900 100.191 76.966  1.00 142.29 ? 257 ASN A CG  1 
ATOM 1584 O OD1 . ASN A 1 257 ? 142.062 99.572  78.019  1.00 141.98 ? 257 ASN A OD1 1 
ATOM 1585 N ND2 . ASN A 1 257 ? 141.623 99.586  75.817  1.00 142.24 ? 257 ASN A ND2 1 
ATOM 1586 N N   . LEU A 1 258 ? 142.242 103.808 79.230  1.00 132.80 ? 258 LEU A N   1 
ATOM 1587 C CA  . LEU A 1 258 ? 142.865 104.197 80.486  1.00 126.23 ? 258 LEU A CA  1 
ATOM 1588 C C   . LEU A 1 258 ? 142.641 105.678 80.735  1.00 129.94 ? 258 LEU A C   1 
ATOM 1589 O O   . LEU A 1 258 ? 142.725 106.491 79.809  1.00 136.11 ? 258 LEU A O   1 
ATOM 1590 C CB  . LEU A 1 258 ? 144.362 103.886 80.475  1.00 127.46 ? 258 LEU A CB  1 
ATOM 1591 C CG  . LEU A 1 258 ? 144.723 102.426 80.739  1.00 131.02 ? 258 LEU A CG  1 
ATOM 1592 C CD1 . LEU A 1 258 ? 146.227 102.224 80.692  1.00 134.14 ? 258 LEU A CD1 1 
ATOM 1593 C CD2 . LEU A 1 258 ? 144.162 101.976 82.075  1.00 133.19 ? 258 LEU A CD2 1 
ATOM 1594 N N   . ILE A 1 259 ? 142.362 106.027 81.987  1.00 113.01 ? 259 ILE A N   1 
ATOM 1595 C CA  . ILE A 1 259 ? 142.091 107.405 82.384  1.00 109.45 ? 259 ILE A CA  1 
ATOM 1596 C C   . ILE A 1 259 ? 143.075 107.788 83.478  1.00 117.93 ? 259 ILE A C   1 
ATOM 1597 O O   . ILE A 1 259 ? 143.173 107.099 84.500  1.00 123.55 ? 259 ILE A O   1 
ATOM 1598 C CB  . ILE A 1 259 ? 140.643 107.583 82.862  1.00 106.67 ? 259 ILE A CB  1 
ATOM 1599 C CG1 . ILE A 1 259 ? 139.685 107.535 81.674  1.00 115.24 ? 259 ILE A CG1 1 
ATOM 1600 C CG2 . ILE A 1 259 ? 140.487 108.890 83.615  1.00 108.57 ? 259 ILE A CG2 1 
ATOM 1601 C CD1 . ILE A 1 259 ? 138.233 107.459 82.071  1.00 118.63 ? 259 ILE A CD1 1 
ATOM 1602 N N   . THR A 1 260 ? 143.799 108.881 83.269  1.00 111.87 ? 260 THR A N   1 
ATOM 1603 C CA  . THR A 1 260 ? 144.722 109.365 84.283  1.00 109.96 ? 260 THR A CA  1 
ATOM 1604 C C   . THR A 1 260 ? 143.957 110.033 85.418  1.00 104.17 ? 260 THR A C   1 
ATOM 1605 O O   . THR A 1 260 ? 142.989 110.762 85.188  1.00 114.82 ? 260 THR A O   1 
ATOM 1606 C CB  . THR A 1 260 ? 145.714 110.349 83.670  1.00 112.03 ? 260 THR A CB  1 
ATOM 1607 O OG1 . THR A 1 260 ? 146.203 109.820 82.433  1.00 115.18 ? 260 THR A OG1 1 
ATOM 1608 C CG2 . THR A 1 260 ? 146.882 110.581 84.607  1.00 115.99 ? 260 THR A CG2 1 
ATOM 1609 N N   . CYS A 1 261 ? 144.391 109.780 86.650  1.00 111.91 ? 261 CYS A N   1 
ATOM 1610 C CA  . CYS A 1 261 ? 143.783 110.397 87.817  1.00 117.97 ? 261 CYS A CA  1 
ATOM 1611 C C   . CYS A 1 261 ? 144.882 110.811 88.781  1.00 124.25 ? 261 CYS A C   1 
ATOM 1612 O O   . CYS A 1 261 ? 145.952 110.199 88.821  1.00 135.26 ? 261 CYS A O   1 
ATOM 1613 C CB  . CYS A 1 261 ? 142.800 109.451 88.510  1.00 126.13 ? 261 CYS A CB  1 
ATOM 1614 S SG  . CYS A 1 261 ? 141.356 109.024 87.515  1.00 160.87 ? 261 CYS A SG  1 
ATOM 1615 N N   . ARG A 1 262 ? 144.611 111.856 89.553  1.00 124.20 ? 262 ARG A N   1 
ATOM 1616 C CA  . ARG A 1 262 ? 145.579 112.417 90.482  1.00 125.93 ? 262 ARG A CA  1 
ATOM 1617 C C   . ARG A 1 262 ? 144.975 112.521 91.872  1.00 128.46 ? 262 ARG A C   1 
ATOM 1618 O O   . ARG A 1 262 ? 143.828 112.958 92.037  1.00 133.54 ? 262 ARG A O   1 
ATOM 1619 C CB  . ARG A 1 262 ? 146.055 113.796 90.025  1.00 128.19 ? 262 ARG A CB  1 
ATOM 1620 C CG  . ARG A 1 262 ? 147.134 114.389 90.907  1.00 132.73 ? 262 ARG A CG  1 
ATOM 1621 C CD  . ARG A 1 262 ? 147.315 115.868 90.654  1.00 133.93 ? 262 ARG A CD  1 
ATOM 1622 N NE  . ARG A 1 262 ? 148.696 116.282 90.857  1.00 135.93 ? 262 ARG A NE  1 
ATOM 1623 C CZ  . ARG A 1 262 ? 149.663 116.127 89.963  1.00 138.32 ? 262 ARG A CZ  1 
ATOM 1624 N NH1 . ARG A 1 262 ? 149.430 115.580 88.782  1.00 132.70 ? 262 ARG A NH1 1 
ATOM 1625 N NH2 . ARG A 1 262 ? 150.894 116.533 90.261  1.00 135.92 ? 262 ARG A NH2 1 
ATOM 1626 N N   . LEU A 1 263 ? 145.757 112.115 92.868  1.00 117.23 ? 263 LEU A N   1 
ATOM 1627 C CA  . LEU A 1 263 ? 145.382 112.292 94.263  1.00 116.08 ? 263 LEU A CA  1 
ATOM 1628 C C   . LEU A 1 263 ? 145.625 113.735 94.677  1.00 119.24 ? 263 LEU A C   1 
ATOM 1629 O O   . LEU A 1 263 ? 146.688 114.298 94.403  1.00 124.51 ? 263 LEU A O   1 
ATOM 1630 C CB  . LEU A 1 263 ? 146.179 111.345 95.156  1.00 113.67 ? 263 LEU A CB  1 
ATOM 1631 C CG  . LEU A 1 263 ? 146.015 109.852 94.884  1.00 117.34 ? 263 LEU A CG  1 
ATOM 1632 C CD1 . LEU A 1 263 ? 147.200 109.313 94.106  1.00 117.57 ? 263 LEU A CD1 1 
ATOM 1633 C CD2 . LEU A 1 263 ? 145.845 109.097 96.187  1.00 123.93 ? 263 LEU A CD2 1 
ATOM 1634 N N   . THR A 1 264 ? 144.638 114.332 95.338  1.00 132.47 ? 264 THR A N   1 
ATOM 1635 C CA  . THR A 1 264 ? 144.705 115.726 95.746  1.00 134.52 ? 264 THR A CA  1 
ATOM 1636 C C   . THR A 1 264 ? 145.055 115.892 97.216  1.00 135.22 ? 264 THR A C   1 
ATOM 1637 O O   . THR A 1 264 ? 145.016 117.014 97.728  1.00 136.44 ? 264 THR A O   1 
ATOM 1638 C CB  . THR A 1 264 ? 143.377 116.419 95.453  1.00 141.10 ? 264 THR A CB  1 
ATOM 1639 O OG1 . THR A 1 264 ? 142.441 116.110 96.491  1.00 144.44 ? 264 THR A OG1 1 
ATOM 1640 C CG2 . THR A 1 264 ? 142.818 115.935 94.129  1.00 140.11 ? 264 THR A CG2 1 
ATOM 1641 N N   . SER A 1 265 ? 145.391 114.805 97.909  1.00 127.26 ? 265 SER A N   1 
ATOM 1642 C CA  . SER A 1 265 ? 145.653 114.861 99.341  1.00 127.01 ? 265 SER A CA  1 
ATOM 1643 C C   . SER A 1 265 ? 146.946 114.143 99.700  1.00 126.87 ? 265 SER A C   1 
ATOM 1644 O O   . SER A 1 265 ? 147.054 113.552 100.777 1.00 134.70 ? 265 SER A O   1 
ATOM 1645 C CB  . SER A 1 265 ? 144.483 114.275 100.129 1.00 132.51 ? 265 SER A CB  1 
ATOM 1646 O OG  . SER A 1 265 ? 143.373 115.154 100.110 1.00 132.79 ? 265 SER A OG  1 
ATOM 1647 N N   . LEU A 1 266 ? 147.937 114.180 98.809  1.00 98.13  ? 266 LEU A N   1 
ATOM 1648 C CA  . LEU A 1 266 ? 149.218 113.556 99.121  1.00 98.46  ? 266 LEU A CA  1 
ATOM 1649 C C   . LEU A 1 266 ? 149.956 114.313 100.217 1.00 107.98 ? 266 LEU A C   1 
ATOM 1650 O O   . LEU A 1 266 ? 150.673 113.699 101.016 1.00 115.22 ? 266 LEU A O   1 
ATOM 1651 C CB  . LEU A 1 266 ? 150.082 113.471 97.866  1.00 99.85  ? 266 LEU A CB  1 
ATOM 1652 C CG  . LEU A 1 266 ? 151.172 112.404 97.917  1.00 108.29 ? 266 LEU A CG  1 
ATOM 1653 C CD1 . LEU A 1 266 ? 150.574 111.053 98.256  1.00 114.76 ? 266 LEU A CD1 1 
ATOM 1654 C CD2 . LEU A 1 266 ? 151.926 112.342 96.606  1.00 111.11 ? 266 LEU A CD2 1 
ATOM 1655 N N   . SER A 1 267 ? 149.796 115.637 100.264 1.00 113.81 ? 267 SER A N   1 
ATOM 1656 C CA  . SER A 1 267 ? 150.467 116.429 101.289 1.00 118.83 ? 267 SER A CA  1 
ATOM 1657 C C   . SER A 1 267 ? 149.973 116.067 102.681 1.00 120.48 ? 267 SER A C   1 
ATOM 1658 O O   . SER A 1 267 ? 150.771 115.936 103.617 1.00 128.58 ? 267 SER A O   1 
ATOM 1659 C CB  . SER A 1 267 ? 150.256 117.916 101.015 1.00 123.85 ? 267 SER A CB  1 
ATOM 1660 O OG  . SER A 1 267 ? 150.649 118.244 99.694  1.00 129.73 ? 267 SER A OG  1 
ATOM 1661 N N   . ILE A 1 268 ? 148.659 115.896 102.836 1.00 114.41 ? 268 ILE A N   1 
ATOM 1662 C CA  . ILE A 1 268 ? 148.100 115.496 104.126 1.00 115.80 ? 268 ILE A CA  1 
ATOM 1663 C C   . ILE A 1 268 ? 148.628 114.126 104.526 1.00 115.14 ? 268 ILE A C   1 
ATOM 1664 O O   . ILE A 1 268 ? 148.995 113.898 105.684 1.00 120.19 ? 268 ILE A O   1 
ATOM 1665 C CB  . ILE A 1 268 ? 146.562 115.516 104.067 1.00 115.73 ? 268 ILE A CB  1 
ATOM 1666 C CG1 . ILE A 1 268 ? 146.039 116.952 104.104 1.00 125.47 ? 268 ILE A CG1 1 
ATOM 1667 C CG2 . ILE A 1 268 ? 145.967 114.721 105.214 1.00 111.67 ? 268 ILE A CG2 1 
ATOM 1668 C CD1 . ILE A 1 268 ? 146.853 117.877 104.968 1.00 132.19 ? 268 ILE A CD1 1 
ATOM 1669 N N   . PHE A 1 269 ? 148.679 113.202 103.567 1.00 109.72 ? 269 PHE A N   1 
ATOM 1670 C CA  . PHE A 1 269 ? 149.209 111.867 103.819 1.00 110.57 ? 269 PHE A CA  1 
ATOM 1671 C C   . PHE A 1 269 ? 150.643 111.930 104.333 1.00 117.32 ? 269 PHE A C   1 
ATOM 1672 O O   . PHE A 1 269 ? 150.972 111.348 105.377 1.00 129.21 ? 269 PHE A O   1 
ATOM 1673 C CB  . PHE A 1 269 ? 149.130 111.052 102.530 1.00 111.41 ? 269 PHE A CB  1 
ATOM 1674 C CG  . PHE A 1 269 ? 149.447 109.605 102.700 1.00 108.74 ? 269 PHE A CG  1 
ATOM 1675 C CD1 . PHE A 1 269 ? 148.549 108.752 103.307 1.00 110.62 ? 269 PHE A CD1 1 
ATOM 1676 C CD2 . PHE A 1 269 ? 150.643 109.092 102.236 1.00 116.28 ? 269 PHE A CD2 1 
ATOM 1677 C CE1 . PHE A 1 269 ? 148.840 107.416 103.453 1.00 120.78 ? 269 PHE A CE1 1 
ATOM 1678 C CE2 . PHE A 1 269 ? 150.940 107.760 102.384 1.00 117.24 ? 269 PHE A CE2 1 
ATOM 1679 C CZ  . PHE A 1 269 ? 150.039 106.919 102.992 1.00 119.94 ? 269 PHE A CZ  1 
ATOM 1680 N N   . GLN A 1 270 ? 151.506 112.657 103.617 1.00 120.07 ? 270 GLN A N   1 
ATOM 1681 C CA  . GLN A 1 270 ? 152.910 112.746 104.004 1.00 124.49 ? 270 GLN A CA  1 
ATOM 1682 C C   . GLN A 1 270 ? 153.068 113.397 105.369 1.00 133.90 ? 270 GLN A C   1 
ATOM 1683 O O   . GLN A 1 270 ? 153.839 112.917 106.211 1.00 141.08 ? 270 GLN A O   1 
ATOM 1684 C CB  . GLN A 1 270 ? 153.692 113.535 102.957 1.00 123.80 ? 270 GLN A CB  1 
ATOM 1685 C CG  . GLN A 1 270 ? 153.897 112.810 101.648 1.00 127.64 ? 270 GLN A CG  1 
ATOM 1686 C CD  . GLN A 1 270 ? 154.194 113.760 100.508 1.00 136.03 ? 270 GLN A CD  1 
ATOM 1687 O OE1 . GLN A 1 270 ? 153.314 114.089 99.715  1.00 139.37 ? 270 GLN A OE1 1 
ATOM 1688 N NE2 . GLN A 1 270 ? 155.438 114.212 100.423 1.00 137.05 ? 270 GLN A NE2 1 
ATOM 1689 N N   . ILE A 1 271 ? 152.342 114.493 105.608 1.00 121.09 ? 271 ILE A N   1 
ATOM 1690 C CA  . ILE A 1 271 ? 152.477 115.220 106.863 1.00 117.41 ? 271 ILE A CA  1 
ATOM 1691 C C   . ILE A 1 271 ? 152.009 114.364 108.032 1.00 121.77 ? 271 ILE A C   1 
ATOM 1692 O O   . ILE A 1 271 ? 152.675 114.301 109.072 1.00 130.00 ? 271 ILE A O   1 
ATOM 1693 C CB  . ILE A 1 271 ? 151.712 116.551 106.779 1.00 117.47 ? 271 ILE A CB  1 
ATOM 1694 C CG1 . ILE A 1 271 ? 152.546 117.576 106.011 1.00 122.41 ? 271 ILE A CG1 1 
ATOM 1695 C CG2 . ILE A 1 271 ? 151.373 117.073 108.161 1.00 122.12 ? 271 ILE A CG2 1 
ATOM 1696 C CD1 . ILE A 1 271 ? 151.788 118.816 105.633 1.00 125.41 ? 271 ILE A CD1 1 
ATOM 1697 N N   . VAL A 1 272 ? 150.877 113.676 107.873 1.00 113.96 ? 272 VAL A N   1 
ATOM 1698 C CA  . VAL A 1 272 ? 150.360 112.832 108.946 1.00 111.74 ? 272 VAL A CA  1 
ATOM 1699 C C   . VAL A 1 272 ? 151.339 111.708 109.254 1.00 116.82 ? 272 VAL A C   1 
ATOM 1700 O O   . VAL A 1 272 ? 151.656 111.442 110.421 1.00 122.76 ? 272 VAL A O   1 
ATOM 1701 C CB  . VAL A 1 272 ? 148.969 112.288 108.572 1.00 109.72 ? 272 VAL A CB  1 
ATOM 1702 C CG1 . VAL A 1 272 ? 148.678 110.996 109.312 1.00 116.00 ? 272 VAL A CG1 1 
ATOM 1703 C CG2 . VAL A 1 272 ? 147.904 113.325 108.874 1.00 113.81 ? 272 VAL A CG2 1 
ATOM 1704 N N   . SER A 1 273 ? 151.856 111.050 108.211 1.00 117.45 ? 273 SER A N   1 
ATOM 1705 C CA  . SER A 1 273 ? 152.788 109.947 108.429 1.00 119.22 ? 273 SER A CA  1 
ATOM 1706 C C   . SER A 1 273 ? 154.045 110.418 109.153 1.00 124.75 ? 273 SER A C   1 
ATOM 1707 O O   . SER A 1 273 ? 154.453 109.827 110.165 1.00 133.15 ? 273 SER A O   1 
ATOM 1708 C CB  . SER A 1 273 ? 153.147 109.299 107.094 1.00 119.21 ? 273 SER A CB  1 
ATOM 1709 O OG  . SER A 1 273 ? 154.443 108.730 107.145 1.00 127.20 ? 273 SER A OG  1 
ATOM 1710 N N   . LEU A 1 274 ? 154.661 111.495 108.657 1.00 115.53 ? 274 LEU A N   1 
ATOM 1711 C CA  . LEU A 1 274 ? 155.902 111.979 109.254 1.00 115.56 ? 274 LEU A CA  1 
ATOM 1712 C C   . LEU A 1 274 ? 155.685 112.440 110.689 1.00 124.13 ? 274 LEU A C   1 
ATOM 1713 O O   . LEU A 1 274 ? 156.479 112.110 111.582 1.00 129.15 ? 274 LEU A O   1 
ATOM 1714 C CB  . LEU A 1 274 ? 156.482 113.111 108.411 1.00 116.77 ? 274 LEU A CB  1 
ATOM 1715 C CG  . LEU A 1 274 ? 157.661 112.737 107.517 1.00 125.88 ? 274 LEU A CG  1 
ATOM 1716 C CD1 . LEU A 1 274 ? 158.805 112.198 108.351 1.00 128.59 ? 274 LEU A CD1 1 
ATOM 1717 C CD2 . LEU A 1 274 ? 157.238 111.725 106.470 1.00 128.47 ? 274 LEU A CD2 1 
ATOM 1718 N N   . SER A 1 275 ? 154.611 113.195 110.935 1.00 133.25 ? 275 SER A N   1 
ATOM 1719 C CA  . SER A 1 275 ? 154.351 113.695 112.278 1.00 131.31 ? 275 SER A CA  1 
ATOM 1720 C C   . SER A 1 275 ? 154.107 112.556 113.253 1.00 129.91 ? 275 SER A C   1 
ATOM 1721 O O   . SER A 1 275 ? 154.641 112.567 114.369 1.00 140.23 ? 275 SER A O   1 
ATOM 1722 C CB  . SER A 1 275 ? 153.161 114.650 112.260 1.00 129.59 ? 275 SER A CB  1 
ATOM 1723 O OG  . SER A 1 275 ? 151.962 113.962 112.565 1.00 128.87 ? 275 SER A OG  1 
ATOM 1724 N N   . SER A 1 276 ? 153.303 111.563 112.853 1.00 115.75 ? 276 SER A N   1 
ATOM 1725 C CA  . SER A 1 276 ? 153.020 110.443 113.741 1.00 115.54 ? 276 SER A CA  1 
ATOM 1726 C C   . SER A 1 276 ? 154.282 109.660 114.064 1.00 118.03 ? 276 SER A C   1 
ATOM 1727 O O   . SER A 1 276 ? 154.514 109.292 115.226 1.00 129.88 ? 276 SER A O   1 
ATOM 1728 C CB  . SER A 1 276 ? 151.970 109.529 113.111 1.00 117.42 ? 276 SER A CB  1 
ATOM 1729 O OG  . SER A 1 276 ? 152.169 108.187 113.513 1.00 123.58 ? 276 SER A OG  1 
ATOM 1730 N N   . VAL A 1 277 ? 155.120 109.408 113.053 1.00 114.34 ? 277 VAL A N   1 
ATOM 1731 C CA  . VAL A 1 277 ? 156.377 108.705 113.298 1.00 112.17 ? 277 VAL A CA  1 
ATOM 1732 C C   . VAL A 1 277 ? 157.235 109.487 114.283 1.00 119.22 ? 277 VAL A C   1 
ATOM 1733 O O   . VAL A 1 277 ? 157.788 108.917 115.233 1.00 128.47 ? 277 VAL A O   1 
ATOM 1734 C CB  . VAL A 1 277 ? 157.118 108.448 111.973 1.00 123.28 ? 277 VAL A CB  1 
ATOM 1735 C CG1 . VAL A 1 277 ? 158.621 108.378 112.196 1.00 119.90 ? 277 VAL A CG1 1 
ATOM 1736 C CG2 . VAL A 1 277 ? 156.626 107.166 111.339 1.00 125.88 ? 277 VAL A CG2 1 
ATOM 1737 N N   . ALA A 1 278 ? 157.327 110.807 114.098 1.00 129.78 ? 278 ALA A N   1 
ATOM 1738 C CA  . ALA A 1 278 ? 158.172 111.618 114.970 1.00 132.02 ? 278 ALA A CA  1 
ATOM 1739 C C   . ALA A 1 278 ? 157.682 111.590 116.415 1.00 127.81 ? 278 ALA A C   1 
ATOM 1740 O O   . ALA A 1 278 ? 158.474 111.396 117.348 1.00 131.86 ? 278 ALA A O   1 
ATOM 1741 C CB  . ALA A 1 278 ? 158.230 113.055 114.453 1.00 133.00 ? 278 ALA A CB  1 
ATOM 1742 N N   . ILE A 1 279 ? 156.376 111.773 116.626 1.00 123.25 ? 279 ILE A N   1 
ATOM 1743 C CA  . ILE A 1 279 ? 155.900 111.882 118.002 1.00 123.14 ? 279 ILE A CA  1 
ATOM 1744 C C   . ILE A 1 279 ? 155.977 110.528 118.699 1.00 126.95 ? 279 ILE A C   1 
ATOM 1745 O O   . ILE A 1 279 ? 156.353 110.440 119.875 1.00 135.07 ? 279 ILE A O   1 
ATOM 1746 C CB  . ILE A 1 279 ? 154.483 112.480 118.069 1.00 128.21 ? 279 ILE A CB  1 
ATOM 1747 C CG1 . ILE A 1 279 ? 153.871 112.239 119.440 1.00 130.10 ? 279 ILE A CG1 1 
ATOM 1748 C CG2 . ILE A 1 279 ? 153.561 111.794 117.107 1.00 135.13 ? 279 ILE A CG2 1 
ATOM 1749 C CD1 . ILE A 1 279 ? 152.552 112.901 119.607 1.00 133.33 ? 279 ILE A CD1 1 
ATOM 1750 N N   . TYR A 1 280 ? 155.648 109.444 117.989 1.00 128.53 ? 280 TYR A N   1 
ATOM 1751 C CA  . TYR A 1 280 ? 155.738 108.141 118.633 1.00 122.65 ? 280 TYR A CA  1 
ATOM 1752 C C   . TYR A 1 280 ? 157.178 107.667 118.766 1.00 125.90 ? 280 TYR A C   1 
ATOM 1753 O O   . TYR A 1 280 ? 157.437 106.721 119.516 1.00 127.09 ? 280 TYR A O   1 
ATOM 1754 C CB  . TYR A 1 280 ? 154.891 107.124 117.877 1.00 124.27 ? 280 TYR A CB  1 
ATOM 1755 C CG  . TYR A 1 280 ? 153.445 107.175 118.302 1.00 125.09 ? 280 TYR A CG  1 
ATOM 1756 C CD1 . TYR A 1 280 ? 153.056 106.716 119.549 1.00 123.44 ? 280 TYR A CD1 1 
ATOM 1757 C CD2 . TYR A 1 280 ? 152.476 107.713 117.470 1.00 132.97 ? 280 TYR A CD2 1 
ATOM 1758 C CE1 . TYR A 1 280 ? 151.738 106.772 119.949 1.00 129.24 ? 280 TYR A CE1 1 
ATOM 1759 C CE2 . TYR A 1 280 ? 151.156 107.773 117.861 1.00 128.62 ? 280 TYR A CE2 1 
ATOM 1760 C CZ  . TYR A 1 280 ? 150.793 107.302 119.102 1.00 130.40 ? 280 TYR A CZ  1 
ATOM 1761 O OH  . TYR A 1 280 ? 149.479 107.360 119.496 1.00 136.47 ? 280 TYR A OH  1 
ATOM 1762 N N   . THR A 1 281 ? 158.119 108.298 118.060 1.00 134.92 ? 281 THR A N   1 
ATOM 1763 C CA  . THR A 1 281 ? 159.527 108.101 118.386 1.00 131.17 ? 281 THR A CA  1 
ATOM 1764 C C   . THR A 1 281 ? 159.888 108.826 119.673 1.00 131.37 ? 281 THR A C   1 
ATOM 1765 O O   . THR A 1 281 ? 160.591 108.277 120.530 1.00 137.69 ? 281 THR A O   1 
ATOM 1766 C CB  . THR A 1 281 ? 160.400 108.585 117.227 1.00 138.52 ? 281 THR A CB  1 
ATOM 1767 O OG1 . THR A 1 281 ? 160.437 107.582 116.206 1.00 148.27 ? 281 THR A OG1 1 
ATOM 1768 C CG2 . THR A 1 281 ? 161.822 108.866 117.693 1.00 138.41 ? 281 THR A CG2 1 
ATOM 1769 N N   . ILE A 1 282 ? 159.396 110.056 119.829 1.00 127.87 ? 282 ILE A N   1 
ATOM 1770 C CA  . ILE A 1 282 ? 159.694 110.839 121.027 1.00 130.28 ? 282 ILE A CA  1 
ATOM 1771 C C   . ILE A 1 282 ? 159.129 110.159 122.271 1.00 132.10 ? 282 ILE A C   1 
ATOM 1772 O O   . ILE A 1 282 ? 159.750 110.169 123.340 1.00 137.43 ? 282 ILE A O   1 
ATOM 1773 C CB  . ILE A 1 282 ? 159.159 112.275 120.860 1.00 136.54 ? 282 ILE A CB  1 
ATOM 1774 C CG1 . ILE A 1 282 ? 160.161 113.124 120.080 1.00 142.43 ? 282 ILE A CG1 1 
ATOM 1775 C CG2 . ILE A 1 282 ? 158.858 112.920 122.202 1.00 133.48 ? 282 ILE A CG2 1 
ATOM 1776 C CD1 . ILE A 1 282 ? 161.543 113.143 120.691 1.00 142.58 ? 282 ILE A CD1 1 
ATOM 1777 N N   . LEU A 1 283 ? 157.961 109.535 122.146 1.00 127.42 ? 283 LEU A N   1 
ATOM 1778 C CA  . LEU A 1 283 ? 157.250 108.999 123.304 1.00 123.54 ? 283 LEU A CA  1 
ATOM 1779 C C   . LEU A 1 283 ? 157.821 107.688 123.836 1.00 118.51 ? 283 LEU A C   1 
ATOM 1780 O O   . LEU A 1 283 ? 157.305 107.180 124.836 1.00 116.93 ? 283 LEU A O   1 
ATOM 1781 C CB  . LEU A 1 283 ? 155.774 108.800 122.964 1.00 128.58 ? 283 LEU A CB  1 
ATOM 1782 C CG  . LEU A 1 283 ? 154.786 109.309 124.011 1.00 125.79 ? 283 LEU A CG  1 
ATOM 1783 C CD1 . LEU A 1 283 ? 155.041 110.773 124.311 1.00 124.47 ? 283 LEU A CD1 1 
ATOM 1784 C CD2 . LEU A 1 283 ? 153.361 109.094 123.541 1.00 126.62 ? 283 LEU A CD2 1 
ATOM 1785 N N   . VAL A 1 284 ? 158.839 107.115 123.205 1.00 114.54 ? 284 VAL A N   1 
ATOM 1786 C CA  . VAL A 1 284 ? 159.377 105.824 123.640 1.00 113.82 ? 284 VAL A CA  1 
ATOM 1787 C C   . VAL A 1 284 ? 160.324 105.955 124.837 1.00 122.03 ? 284 VAL A C   1 
ATOM 1788 O O   . VAL A 1 284 ? 160.173 105.184 125.801 1.00 134.52 ? 284 VAL A O   1 
ATOM 1789 C CB  . VAL A 1 284 ? 160.048 105.089 122.466 1.00 115.25 ? 284 VAL A CB  1 
ATOM 1790 C CG1 . VAL A 1 284 ? 161.018 104.034 122.967 1.00 111.90 ? 284 VAL A CG1 1 
ATOM 1791 C CG2 . VAL A 1 284 ? 158.996 104.463 121.574 1.00 123.12 ? 284 VAL A CG2 1 
ATOM 1792 N N   . PRO A 1 285 ? 161.315 106.868 124.837 1.00 124.10 ? 285 PRO A N   1 
ATOM 1793 C CA  . PRO A 1 285 ? 162.219 106.930 126.001 1.00 128.09 ? 285 PRO A CA  1 
ATOM 1794 C C   . PRO A 1 285 ? 161.527 107.226 127.318 1.00 130.32 ? 285 PRO A C   1 
ATOM 1795 O O   . PRO A 1 285 ? 161.941 106.694 128.354 1.00 138.85 ? 285 PRO A O   1 
ATOM 1796 C CB  . PRO A 1 285 ? 163.201 108.045 125.617 1.00 126.70 ? 285 PRO A CB  1 
ATOM 1797 C CG  . PRO A 1 285 ? 163.220 108.014 124.154 1.00 134.73 ? 285 PRO A CG  1 
ATOM 1798 C CD  . PRO A 1 285 ? 161.797 107.765 123.770 1.00 128.58 ? 285 PRO A CD  1 
ATOM 1799 N N   . VAL A 1 286 ? 160.480 108.050 127.321 1.00 118.31 ? 286 VAL A N   1 
ATOM 1800 C CA  . VAL A 1 286 ? 159.779 108.317 128.573 1.00 124.48 ? 286 VAL A CA  1 
ATOM 1801 C C   . VAL A 1 286 ? 159.067 107.061 129.060 1.00 125.56 ? 286 VAL A C   1 
ATOM 1802 O O   . VAL A 1 286 ? 159.042 106.768 130.264 1.00 129.97 ? 286 VAL A O   1 
ATOM 1803 C CB  . VAL A 1 286 ? 158.818 109.509 128.403 1.00 124.77 ? 286 VAL A CB  1 
ATOM 1804 C CG1 . VAL A 1 286 ? 157.976 109.351 127.153 1.00 127.02 ? 286 VAL A CG1 1 
ATOM 1805 C CG2 . VAL A 1 286 ? 157.944 109.678 129.630 1.00 125.62 ? 286 VAL A CG2 1 
ATOM 1806 N N   . ILE A 1 287 ? 158.508 106.277 128.134 1.00 113.93 ? 287 ILE A N   1 
ATOM 1807 C CA  . ILE A 1 287 ? 157.851 105.028 128.506 1.00 107.27 ? 287 ILE A CA  1 
ATOM 1808 C C   . ILE A 1 287 ? 158.857 104.055 129.106 1.00 106.08 ? 287 ILE A C   1 
ATOM 1809 O O   . ILE A 1 287 ? 158.600 103.428 130.142 1.00 121.98 ? 287 ILE A O   1 
ATOM 1810 C CB  . ILE A 1 287 ? 157.135 104.418 127.287 1.00 120.06 ? 287 ILE A CB  1 
ATOM 1811 C CG1 . ILE A 1 287 ? 155.821 105.151 127.026 1.00 123.59 ? 287 ILE A CG1 1 
ATOM 1812 C CG2 . ILE A 1 287 ? 156.889 102.933 127.491 1.00 114.25 ? 287 ILE A CG2 1 
ATOM 1813 C CD1 . ILE A 1 287 ? 154.741 104.819 128.021 1.00 123.80 ? 287 ILE A CD1 1 
ATOM 1814 N N   . ILE A 1 288 ? 160.022 103.917 128.470 1.00 107.04 ? 288 ILE A N   1 
ATOM 1815 C CA  . ILE A 1 288 ? 160.997 102.966 128.995 1.00 114.95 ? 288 ILE A CA  1 
ATOM 1816 C C   . ILE A 1 288 ? 161.578 103.467 130.316 1.00 122.37 ? 288 ILE A C   1 
ATOM 1817 O O   . ILE A 1 288 ? 161.916 102.661 131.191 1.00 130.56 ? 288 ILE A O   1 
ATOM 1818 C CB  . ILE A 1 288 ? 162.089 102.653 127.952 1.00 118.03 ? 288 ILE A CB  1 
ATOM 1819 C CG1 . ILE A 1 288 ? 162.849 101.387 128.349 1.00 125.54 ? 288 ILE A CG1 1 
ATOM 1820 C CG2 . ILE A 1 288 ? 163.066 103.796 127.797 1.00 122.24 ? 288 ILE A CG2 1 
ATOM 1821 C CD1 . ILE A 1 288 ? 163.124 100.460 127.192 1.00 127.52 ? 288 ILE A CD1 1 
ATOM 1822 N N   . TYR A 1 289 ? 161.672 104.786 130.501 1.00 137.06 ? 289 TYR A N   1 
ATOM 1823 C CA  . TYR A 1 289 ? 162.104 105.320 131.789 1.00 139.48 ? 289 TYR A CA  1 
ATOM 1824 C C   . TYR A 1 289 ? 161.097 104.999 132.883 1.00 137.84 ? 289 TYR A C   1 
ATOM 1825 O O   . TYR A 1 289 ? 161.479 104.613 133.995 1.00 139.17 ? 289 TYR A O   1 
ATOM 1826 C CB  . TYR A 1 289 ? 162.313 106.828 131.687 1.00 144.53 ? 289 TYR A CB  1 
ATOM 1827 C CG  . TYR A 1 289 ? 162.510 107.507 133.021 1.00 143.89 ? 289 TYR A CG  1 
ATOM 1828 C CD1 . TYR A 1 289 ? 163.559 107.150 133.856 1.00 146.81 ? 289 TYR A CD1 1 
ATOM 1829 C CD2 . TYR A 1 289 ? 161.643 108.501 133.449 1.00 142.64 ? 289 TYR A CD2 1 
ATOM 1830 C CE1 . TYR A 1 289 ? 163.742 107.766 135.076 1.00 151.15 ? 289 TYR A CE1 1 
ATOM 1831 C CE2 . TYR A 1 289 ? 161.817 109.124 134.668 1.00 143.76 ? 289 TYR A CE2 1 
ATOM 1832 C CZ  . TYR A 1 289 ? 162.868 108.753 135.478 1.00 151.96 ? 289 TYR A CZ  1 
ATOM 1833 O OH  . TYR A 1 289 ? 163.047 109.369 136.693 1.00 155.87 ? 289 TYR A OH  1 
ATOM 1834 N N   . ASN A 1 290 ? 159.805 105.157 132.588 1.00 138.59 ? 290 ASN A N   1 
ATOM 1835 C CA  . ASN A 1 290 ? 158.779 104.809 133.564 1.00 143.06 ? 290 ASN A CA  1 
ATOM 1836 C C   . ASN A 1 290 ? 158.810 103.324 133.891 1.00 139.50 ? 290 ASN A C   1 
ATOM 1837 O O   . ASN A 1 290 ? 158.624 102.930 135.048 1.00 136.47 ? 290 ASN A O   1 
ATOM 1838 C CB  . ASN A 1 290 ? 157.400 105.214 133.047 1.00 144.08 ? 290 ASN A CB  1 
ATOM 1839 C CG  . ASN A 1 290 ? 156.933 106.533 133.612 1.00 148.18 ? 290 ASN A CG  1 
ATOM 1840 O OD1 . ASN A 1 290 ? 157.434 106.991 134.637 1.00 152.31 ? 290 ASN A OD1 1 
ATOM 1841 N ND2 . ASN A 1 290 ? 155.971 107.156 132.946 1.00 150.68 ? 290 ASN A ND2 1 
ATOM 1842 N N   . LEU A 1 291 ? 159.036 102.483 132.881 1.00 134.04 ? 291 LEU A N   1 
ATOM 1843 C CA  . LEU A 1 291 ? 159.112 101.046 133.121 1.00 125.93 ? 291 LEU A CA  1 
ATOM 1844 C C   . LEU A 1 291 ? 160.325 100.685 133.970 1.00 128.15 ? 291 LEU A C   1 
ATOM 1845 O O   . LEU A 1 291 ? 160.233 99.831  134.858 1.00 139.11 ? 291 LEU A O   1 
ATOM 1846 C CB  . LEU A 1 291 ? 159.146 100.295 131.792 1.00 131.35 ? 291 LEU A CB  1 
ATOM 1847 C CG  . LEU A 1 291 ? 159.022 98.775  131.869 1.00 135.27 ? 291 LEU A CG  1 
ATOM 1848 C CD1 . LEU A 1 291 ? 158.022 98.280  130.843 1.00 137.16 ? 291 LEU A CD1 1 
ATOM 1849 C CD2 . LEU A 1 291 ? 160.371 98.112  131.660 1.00 138.87 ? 291 LEU A CD2 1 
ATOM 1850 N N   . THR A 1 292 ? 161.465 101.318 133.716 1.00 140.62 ? 292 THR A N   1 
ATOM 1851 C CA  . THR A 1 292 ? 162.700 101.009 134.421 1.00 148.62 ? 292 THR A CA  1 
ATOM 1852 C C   . THR A 1 292 ? 162.840 101.752 135.744 1.00 149.64 ? 292 THR A C   1 
ATOM 1853 O O   . THR A 1 292 ? 163.813 101.517 136.467 1.00 155.48 ? 292 THR A O   1 
ATOM 1854 C CB  . THR A 1 292 ? 163.904 101.317 133.523 1.00 153.14 ? 292 THR A CB  1 
ATOM 1855 O OG1 . THR A 1 292 ? 165.013 100.492 133.900 1.00 155.24 ? 292 THR A OG1 1 
ATOM 1856 C CG2 . THR A 1 292 ? 164.296 102.790 133.614 1.00 153.27 ? 292 THR A CG2 1 
ATOM 1857 N N   . ARG A 1 293 ? 161.890 102.629 136.078 1.00 136.71 ? 293 ARG A N   1 
ATOM 1858 C CA  . ARG A 1 293 ? 162.001 103.419 137.299 1.00 138.26 ? 293 ARG A CA  1 
ATOM 1859 C C   . ARG A 1 293 ? 162.010 102.539 138.543 1.00 143.50 ? 293 ARG A C   1 
ATOM 1860 O O   . ARG A 1 293 ? 162.788 102.777 139.474 1.00 143.73 ? 293 ARG A O   1 
ATOM 1861 C CB  . ARG A 1 293 ? 160.859 104.434 137.360 1.00 137.11 ? 293 ARG A CB  1 
ATOM 1862 C CG  . ARG A 1 293 ? 160.356 104.744 138.755 1.00 137.92 ? 293 ARG A CG  1 
ATOM 1863 C CD  . ARG A 1 293 ? 159.416 105.935 138.742 1.00 141.10 ? 293 ARG A CD  1 
ATOM 1864 N NE  . ARG A 1 293 ? 160.063 107.132 138.220 1.00 143.61 ? 293 ARG A NE  1 
ATOM 1865 C CZ  . ARG A 1 293 ? 160.858 107.922 138.928 1.00 145.33 ? 293 ARG A CZ  1 
ATOM 1866 N NH1 . ARG A 1 293 ? 161.124 107.676 140.200 1.00 144.97 ? 293 ARG A NH1 1 
ATOM 1867 N NH2 . ARG A 1 293 ? 161.398 108.988 138.345 1.00 148.93 ? 293 ARG A NH2 1 
ATOM 1868 N N   . LEU A 1 294 ? 161.166 101.508 138.575 1.00 145.80 ? 294 LEU A N   1 
ATOM 1869 C CA  . LEU A 1 294 ? 161.063 100.669 139.761 1.00 144.73 ? 294 LEU A CA  1 
ATOM 1870 C C   . LEU A 1 294 ? 162.184 99.645  139.876 1.00 146.42 ? 294 LEU A C   1 
ATOM 1871 O O   . LEU A 1 294 ? 162.323 99.029  140.939 1.00 150.66 ? 294 LEU A O   1 
ATOM 1872 C CB  . LEU A 1 294 ? 159.703 99.960  139.788 1.00 140.46 ? 294 LEU A CB  1 
ATOM 1873 C CG  . LEU A 1 294 ? 159.361 98.825  138.815 1.00 143.21 ? 294 LEU A CG  1 
ATOM 1874 C CD1 . LEU A 1 294 ? 159.801 97.447  139.308 1.00 148.53 ? 294 LEU A CD1 1 
ATOM 1875 C CD2 . LEU A 1 294 ? 157.873 98.828  138.543 1.00 142.09 ? 294 LEU A CD2 1 
ATOM 1876 N N   . CYS A 1 295 ? 162.968 99.432  138.816 1.00 166.91 ? 295 CYS A N   1 
ATOM 1877 C CA  . CYS A 1 295 ? 164.012 98.411  138.865 1.00 169.69 ? 295 CYS A CA  1 
ATOM 1878 C C   . CYS A 1 295 ? 165.068 98.746  139.910 1.00 168.32 ? 295 CYS A C   1 
ATOM 1879 O O   . CYS A 1 295 ? 165.520 97.866  140.651 1.00 165.96 ? 295 CYS A O   1 
ATOM 1880 C CB  . CYS A 1 295 ? 164.653 98.248  137.488 1.00 175.56 ? 295 CYS A CB  1 
ATOM 1881 S SG  . CYS A 1 295 ? 165.439 96.642  137.223 1.00 184.71 ? 295 CYS A SG  1 
ATOM 1882 N N   . ARG A 1 296 ? 165.473 100.009 139.983 1.00 183.69 ? 296 ARG A N   1 
ATOM 1883 C CA  . ARG A 1 296 ? 166.379 100.451 141.031 1.00 189.79 ? 296 ARG A CA  1 
ATOM 1884 C C   . ARG A 1 296 ? 165.609 100.645 142.328 1.00 191.01 ? 296 ARG A C   1 
ATOM 1885 O O   . ARG A 1 296 ? 164.472 101.128 142.323 1.00 188.43 ? 296 ARG A O   1 
ATOM 1886 C CB  . ARG A 1 296 ? 167.074 101.750 140.626 1.00 190.77 ? 296 ARG A CB  1 
ATOM 1887 C CG  . ARG A 1 296 ? 168.230 102.150 141.532 1.00 190.73 ? 296 ARG A CG  1 
ATOM 1888 C CD  . ARG A 1 296 ? 169.481 101.352 141.210 1.00 190.41 ? 296 ARG A CD  1 
ATOM 1889 N NE  . ARG A 1 296 ? 169.910 101.543 139.830 1.00 191.59 ? 296 ARG A NE  1 
ATOM 1890 C CZ  . ARG A 1 296 ? 170.383 100.579 139.052 1.00 190.51 ? 296 ARG A CZ  1 
ATOM 1891 N NH1 . ARG A 1 296 ? 170.501 99.336  139.487 1.00 189.24 ? 296 ARG A NH1 1 
ATOM 1892 N NH2 . ARG A 1 296 ? 170.744 100.868 137.806 1.00 188.38 ? 296 ARG A NH2 1 
ATOM 1893 N N   . TRP A 1 297 ? 166.226 100.252 143.440 1.00 207.80 ? 297 TRP A N   1 
ATOM 1894 C CA  . TRP A 1 297 ? 165.559 100.347 144.731 1.00 207.98 ? 297 TRP A CA  1 
ATOM 1895 C C   . TRP A 1 297 ? 165.345 101.811 145.095 1.00 209.27 ? 297 TRP A C   1 
ATOM 1896 O O   . TRP A 1 297 ? 166.249 102.639 144.941 1.00 209.25 ? 297 TRP A O   1 
ATOM 1897 C CB  . TRP A 1 297 ? 166.390 99.658  145.814 1.00 205.41 ? 297 TRP A CB  1 
ATOM 1898 C CG  . TRP A 1 297 ? 165.875 98.309  146.262 1.00 206.76 ? 297 TRP A CG  1 
ATOM 1899 C CD1 . TRP A 1 297 ? 166.595 97.152  146.328 1.00 206.44 ? 297 TRP A CD1 1 
ATOM 1900 C CD2 . TRP A 1 297 ? 164.537 97.968  146.658 1.00 207.33 ? 297 TRP A CD2 1 
ATOM 1901 N NE1 . TRP A 1 297 ? 165.803 96.122  146.768 1.00 207.83 ? 297 TRP A NE1 1 
ATOM 1902 C CE2 . TRP A 1 297 ? 164.533 96.594  146.973 1.00 207.44 ? 297 TRP A CE2 1 
ATOM 1903 C CE3 . TRP A 1 297 ? 163.345 98.689  146.787 1.00 204.94 ? 297 TRP A CE3 1 
ATOM 1904 C CZ2 . TRP A 1 297 ? 163.390 95.929  147.406 1.00 206.02 ? 297 TRP A CZ2 1 
ATOM 1905 C CZ3 . TRP A 1 297 ? 162.210 98.023  147.217 1.00 202.69 ? 297 TRP A CZ3 1 
ATOM 1906 C CH2 . TRP A 1 297 ? 162.243 96.660  147.522 1.00 203.72 ? 297 TRP A CH2 1 
ATOM 1907 N N   . ASP A 1 298 ? 164.149 102.133 145.576 1.00 222.00 ? 298 ASP A N   1 
ATOM 1908 C CA  . ASP A 1 298 ? 163.822 103.511 145.921 1.00 222.68 ? 298 ASP A CA  1 
ATOM 1909 C C   . ASP A 1 298 ? 164.422 103.866 147.277 1.00 225.38 ? 298 ASP A C   1 
ATOM 1910 O O   . ASP A 1 298 ? 164.241 103.138 148.257 1.00 227.01 ? 298 ASP A O   1 
ATOM 1911 C CB  . ASP A 1 298 ? 162.307 103.711 145.941 1.00 221.50 ? 298 ASP A CB  1 
ATOM 1912 C CG  . ASP A 1 298 ? 161.911 105.169 146.093 1.00 220.85 ? 298 ASP A CG  1 
ATOM 1913 O OD1 . ASP A 1 298 ? 162.782 106.049 145.918 1.00 218.69 ? 298 ASP A OD1 1 
ATOM 1914 O OD2 . ASP A 1 298 ? 160.728 105.437 146.385 1.00 219.12 ? 298 ASP A OD2 1 
ATOM 1915 N N   . LYS A 1 299 ? 165.136 104.988 147.327 1.00 220.13 ? 299 LYS A N   1 
ATOM 1916 C CA  . LYS A 1 299 ? 165.757 105.469 148.553 1.00 218.62 ? 299 LYS A CA  1 
ATOM 1917 C C   . LYS A 1 299 ? 165.436 106.943 148.740 1.00 216.70 ? 299 LYS A C   1 
ATOM 1918 O O   . LYS A 1 299 ? 165.403 107.709 147.773 1.00 214.43 ? 299 LYS A O   1 
ATOM 1919 C CB  . LYS A 1 299 ? 167.277 105.265 148.528 1.00 216.25 ? 299 LYS A CB  1 
ATOM 1920 C CG  . LYS A 1 299 ? 167.708 103.810 148.541 1.00 216.43 ? 299 LYS A CG  1 
ATOM 1921 C CD  . LYS A 1 299 ? 168.771 103.547 147.489 1.00 216.88 ? 299 LYS A CD  1 
ATOM 1922 C CE  . LYS A 1 299 ? 169.561 102.289 147.803 1.00 215.65 ? 299 LYS A CE  1 
ATOM 1923 N NZ  . LYS A 1 299 ? 170.807 102.201 146.993 1.00 213.56 ? 299 LYS A NZ  1 
ATOM 1924 N N   . ARG A 1 300 ? 165.201 107.335 149.988 1.00 190.79 ? 300 ARG A N   1 
ATOM 1925 C CA  . ARG A 1 300 ? 164.912 108.727 150.308 1.00 188.50 ? 300 ARG A CA  1 
ATOM 1926 C C   . ARG A 1 300 ? 166.191 109.472 150.681 1.00 189.94 ? 300 ARG A C   1 
ATOM 1927 O O   . ARG A 1 300 ? 167.011 108.970 151.448 1.00 188.50 ? 300 ARG A O   1 
ATOM 1928 C CB  . ARG A 1 300 ? 163.899 108.819 151.448 1.00 186.84 ? 300 ARG A CB  1 
ATOM 1929 C CG  . ARG A 1 300 ? 164.101 107.782 152.539 1.00 185.71 ? 300 ARG A CG  1 
ATOM 1930 C CD  . ARG A 1 300 ? 163.300 108.132 153.779 1.00 185.67 ? 300 ARG A CD  1 
ATOM 1931 N NE  . ARG A 1 300 ? 161.880 108.272 153.485 1.00 191.70 ? 300 ARG A NE  1 
ATOM 1932 C CZ  . ARG A 1 300 ? 161.014 107.267 153.468 1.00 193.16 ? 300 ARG A CZ  1 
ATOM 1933 N NH1 . ARG A 1 300 ? 161.391 106.027 153.733 1.00 193.17 ? 300 ARG A NH1 1 
ATOM 1934 N NH2 . ARG A 1 300 ? 159.740 107.513 153.181 1.00 192.82 ? 300 ARG A NH2 1 
ATOM 1935 N N   . PRO A 1 309 ? 161.605 106.958 163.198 1.00 177.30 ? 309 PRO A N   1 
ATOM 1936 C CA  . PRO A 1 309 ? 161.002 105.770 163.812 1.00 178.91 ? 309 PRO A CA  1 
ATOM 1937 C C   . PRO A 1 309 ? 160.306 104.876 162.792 1.00 180.70 ? 309 PRO A C   1 
ATOM 1938 O O   . PRO A 1 309 ? 160.758 103.760 162.541 1.00 179.69 ? 309 PRO A O   1 
ATOM 1939 C CB  . PRO A 1 309 ? 159.988 106.360 164.797 1.00 175.92 ? 309 PRO A CB  1 
ATOM 1940 C CG  . PRO A 1 309 ? 160.509 107.715 165.109 1.00 175.25 ? 309 PRO A CG  1 
ATOM 1941 C CD  . PRO A 1 309 ? 161.208 108.202 163.877 1.00 174.73 ? 309 PRO A CD  1 
ATOM 1942 N N   . ALA A 1 310 ? 159.209 105.374 162.219 1.00 191.12 ? 310 ALA A N   1 
ATOM 1943 C CA  . ALA A 1 310 ? 158.484 104.605 161.212 1.00 189.81 ? 310 ALA A CA  1 
ATOM 1944 C C   . ALA A 1 310 ? 159.315 104.422 159.948 1.00 192.85 ? 310 ALA A C   1 
ATOM 1945 O O   . ALA A 1 310 ? 159.322 103.335 159.354 1.00 190.11 ? 310 ALA A O   1 
ATOM 1946 C CB  . ALA A 1 310 ? 157.156 105.286 160.889 1.00 187.39 ? 310 ALA A CB  1 
ATOM 1947 N N   . PHE A 1 311 ? 160.019 105.471 159.516 1.00 210.83 ? 311 PHE A N   1 
ATOM 1948 C CA  . PHE A 1 311 ? 160.871 105.342 158.340 1.00 210.03 ? 311 PHE A CA  1 
ATOM 1949 C C   . PHE A 1 311 ? 162.054 104.416 158.603 1.00 211.33 ? 311 PHE A C   1 
ATOM 1950 O O   . PHE A 1 311 ? 162.560 103.782 157.672 1.00 209.82 ? 311 PHE A O   1 
ATOM 1951 C CB  . PHE A 1 311 ? 161.326 106.724 157.856 1.00 208.66 ? 311 PHE A CB  1 
ATOM 1952 C CG  . PHE A 1 311 ? 162.684 107.150 158.355 1.00 211.94 ? 311 PHE A CG  1 
ATOM 1953 C CD1 . PHE A 1 311 ? 162.904 107.400 159.702 1.00 211.54 ? 311 PHE A CD1 1 
ATOM 1954 C CD2 . PHE A 1 311 ? 163.740 107.302 157.470 1.00 209.34 ? 311 PHE A CD2 1 
ATOM 1955 C CE1 . PHE A 1 311 ? 164.151 107.794 160.154 1.00 209.62 ? 311 PHE A CE1 1 
ATOM 1956 C CE2 . PHE A 1 311 ? 164.988 107.694 157.918 1.00 207.28 ? 311 PHE A CE2 1 
ATOM 1957 C CZ  . PHE A 1 311 ? 165.193 107.940 159.262 1.00 207.65 ? 311 PHE A CZ  1 
ATOM 1958 N N   . ASP A 1 312 ? 162.485 104.297 159.862 1.00 215.33 ? 312 ASP A N   1 
ATOM 1959 C CA  . ASP A 1 312 ? 163.490 103.295 160.196 1.00 213.68 ? 312 ASP A CA  1 
ATOM 1960 C C   . ASP A 1 312 ? 162.959 101.884 159.986 1.00 211.93 ? 312 ASP A C   1 
ATOM 1961 O O   . ASP A 1 312 ? 163.674 101.026 159.455 1.00 213.30 ? 312 ASP A O   1 
ATOM 1962 C CB  . ASP A 1 312 ? 163.963 103.479 161.638 1.00 212.75 ? 312 ASP A CB  1 
ATOM 1963 C CG  . ASP A 1 312 ? 164.643 104.814 161.862 1.00 214.27 ? 312 ASP A CG  1 
ATOM 1964 O OD1 . ASP A 1 312 ? 165.635 105.101 161.160 1.00 215.27 ? 312 ASP A OD1 1 
ATOM 1965 O OD2 . ASP A 1 312 ? 164.188 105.578 162.739 1.00 212.85 ? 312 ASP A OD2 1 
ATOM 1966 N N   . LEU A 1 313 ? 161.711 101.626 160.379 1.00 189.14 ? 313 LEU A N   1 
ATOM 1967 C CA  . LEU A 1 313 ? 161.111 100.321 160.130 1.00 188.89 ? 313 LEU A CA  1 
ATOM 1968 C C   . LEU A 1 313 ? 160.916 100.092 158.635 1.00 190.04 ? 313 LEU A C   1 
ATOM 1969 O O   . LEU A 1 313 ? 161.058 98.962  158.151 1.00 190.09 ? 313 LEU A O   1 
ATOM 1970 C CB  . LEU A 1 313 ? 159.784 100.202 160.883 1.00 187.68 ? 313 LEU A CB  1 
ATOM 1971 C CG  . LEU A 1 313 ? 158.766 99.114  160.523 1.00 189.51 ? 313 LEU A CG  1 
ATOM 1972 C CD1 . LEU A 1 313 ? 159.385 97.721  160.554 1.00 190.51 ? 313 LEU A CD1 1 
ATOM 1973 C CD2 . LEU A 1 313 ? 157.584 99.182  161.468 1.00 189.10 ? 313 LEU A CD2 1 
ATOM 1974 N N   . LEU A 1 314 ? 160.600 101.156 157.892 1.00 174.35 ? 314 LEU A N   1 
ATOM 1975 C CA  . LEU A 1 314 ? 160.531 101.051 156.438 1.00 172.48 ? 314 LEU A CA  1 
ATOM 1976 C C   . LEU A 1 314 ? 161.878 100.641 155.854 1.00 171.34 ? 314 LEU A C   1 
ATOM 1977 O O   . LEU A 1 314 ? 161.947 99.777  154.973 1.00 168.09 ? 314 LEU A O   1 
ATOM 1978 C CB  . LEU A 1 314 ? 160.080 102.385 155.843 1.00 170.57 ? 314 LEU A CB  1 
ATOM 1979 C CG  . LEU A 1 314 ? 158.581 102.624 155.669 1.00 168.47 ? 314 LEU A CG  1 
ATOM 1980 C CD1 . LEU A 1 314 ? 158.344 103.906 154.891 1.00 168.43 ? 314 LEU A CD1 1 
ATOM 1981 C CD2 . LEU A 1 314 ? 157.930 101.451 154.968 1.00 169.27 ? 314 LEU A CD2 1 
ATOM 1982 N N   . SER A 1 315 ? 162.961 101.245 156.345 1.00 196.90 ? 315 SER A N   1 
ATOM 1983 C CA  . SER A 1 315 ? 164.294 100.926 155.843 1.00 198.42 ? 315 SER A CA  1 
ATOM 1984 C C   . SER A 1 315 ? 164.750 99.549  156.316 1.00 198.38 ? 315 SER A C   1 
ATOM 1985 O O   . SER A 1 315 ? 165.658 98.952  155.727 1.00 198.66 ? 315 SER A O   1 
ATOM 1986 C CB  . SER A 1 315 ? 165.291 101.999 156.279 1.00 198.91 ? 315 SER A CB  1 
ATOM 1987 O OG  . SER A 1 315 ? 166.577 101.443 156.489 1.00 199.02 ? 315 SER A OG  1 
ATOM 1988 N N   . ARG A 1 316 ? 164.148 99.039  157.391 1.00 202.80 ? 316 ARG A N   1 
ATOM 1989 C CA  . ARG A 1 316 ? 164.541 97.748  157.943 1.00 203.76 ? 316 ARG A CA  1 
ATOM 1990 C C   . ARG A 1 316 ? 164.274 96.611  156.967 1.00 205.11 ? 316 ARG A C   1 
ATOM 1991 O O   . ARG A 1 316 ? 165.084 95.686  156.849 1.00 205.54 ? 316 ARG A O   1 
ATOM 1992 C CB  . ARG A 1 316 ? 163.818 97.486  159.266 1.00 201.53 ? 316 ARG A CB  1 
ATOM 1993 C CG  . ARG A 1 316 ? 164.535 98.063  160.474 1.00 201.02 ? 316 ARG A CG  1 
ATOM 1994 C CD  . ARG A 1 316 ? 163.613 98.146  161.674 1.00 201.26 ? 316 ARG A CD  1 
ATOM 1995 N NE  . ARG A 1 316 ? 163.694 99.445  162.330 1.00 203.83 ? 316 ARG A NE  1 
ATOM 1996 C CZ  . ARG A 1 316 ? 164.422 99.698  163.409 1.00 204.22 ? 316 ARG A CZ  1 
ATOM 1997 N NH1 . ARG A 1 316 ? 165.159 98.761  163.982 1.00 204.07 ? 316 ARG A NH1 1 
ATOM 1998 N NH2 . ARG A 1 316 ? 164.411 100.924 163.925 1.00 202.38 ? 316 ARG A NH2 1 
ATOM 1999 N N   . LYS A 1 317 ? 163.143 96.661  156.264 1.00 201.30 ? 317 LYS A N   1 
ATOM 2000 C CA  . LYS A 1 317 ? 162.852 95.643  155.264 1.00 201.18 ? 317 LYS A CA  1 
ATOM 2001 C C   . LYS A 1 317 ? 163.075 96.192  153.862 1.00 200.54 ? 317 LYS A C   1 
ATOM 2002 O O   . LYS A 1 317 ? 162.320 95.881  152.937 1.00 197.80 ? 317 LYS A O   1 
ATOM 2003 C CB  . LYS A 1 317 ? 161.428 95.113  155.404 1.00 196.75 ? 317 LYS A CB  1 
ATOM 2004 C CG  . LYS A 1 317 ? 161.179 94.355  156.693 1.00 197.05 ? 317 LYS A CG  1 
ATOM 2005 C CD  . LYS A 1 317 ? 159.998 93.406  156.559 1.00 197.62 ? 317 LYS A CD  1 
ATOM 2006 C CE  . LYS A 1 317 ? 160.016 92.699  155.209 1.00 197.10 ? 317 LYS A CE  1 
ATOM 2007 N NZ  . LYS A 1 317 ? 158.736 92.005  154.914 1.00 196.07 ? 317 LYS A NZ  1 
ATOM 2008 N N   . MET A 1 318 ? 164.122 96.999  153.695 1.00 207.14 ? 318 MET A N   1 
ATOM 2009 C CA  . MET A 1 318 ? 164.413 97.672  152.435 1.00 205.44 ? 318 MET A CA  1 
ATOM 2010 C C   . MET A 1 318 ? 165.597 96.928  151.800 1.00 204.83 ? 318 MET A C   1 
ATOM 2011 O O   . MET A 1 318 ? 166.755 97.332  151.930 1.00 204.88 ? 318 MET A O   1 
ATOM 2012 C CB  . MET A 1 318 ? 164.727 99.161  152.682 1.00 206.40 ? 318 MET A CB  1 
ATOM 2013 C CG  . MET A 1 318 ? 165.240 100.009 151.505 1.00 208.32 ? 318 MET A CG  1 
ATOM 2014 S SD  . MET A 1 318 ? 164.585 99.697  149.852 1.00 208.24 ? 318 MET A SD  1 
ATOM 2015 C CE  . MET A 1 318 ? 162.812 99.669  150.153 1.00 205.87 ? 318 MET A CE  1 
ATOM 2016 N N   . LEU A 1 319 ? 165.296 95.821  151.125 1.00 203.70 ? 319 LEU A N   1 
ATOM 2017 C CA  . LEU A 1 319 ? 166.320 94.927  150.592 1.00 205.44 ? 319 LEU A CA  1 
ATOM 2018 C C   . LEU A 1 319 ? 165.642 93.873  149.728 1.00 208.33 ? 319 LEU A C   1 
ATOM 2019 O O   . LEU A 1 319 ? 164.422 93.881  149.544 1.00 208.42 ? 319 LEU A O   1 
ATOM 2020 C CB  . LEU A 1 319 ? 167.139 94.253  151.700 1.00 207.17 ? 319 LEU A CB  1 
ATOM 2021 C CG  . LEU A 1 319 ? 166.470 93.200  152.591 1.00 206.20 ? 319 LEU A CG  1 
ATOM 2022 C CD1 . LEU A 1 319 ? 167.530 92.365  153.277 1.00 204.93 ? 319 LEU A CD1 1 
ATOM 2023 C CD2 . LEU A 1 319 ? 165.574 93.830  153.636 1.00 205.49 ? 319 LEU A CD2 1 
ATOM 2024 N N   . GLY A 1 320 ? 166.455 92.960  149.202 1.00 230.15 ? 320 GLY A N   1 
ATOM 2025 C CA  . GLY A 1 320 ? 165.974 91.838  148.417 1.00 230.69 ? 320 GLY A CA  1 
ATOM 2026 C C   . GLY A 1 320 ? 165.693 92.217  146.976 1.00 232.09 ? 320 GLY A C   1 
ATOM 2027 O O   . GLY A 1 320 ? 166.044 93.298  146.495 1.00 233.41 ? 320 GLY A O   1 
ATOM 2028 N N   . CYS A 1 321 ? 165.052 91.283  146.279 1.00 200.90 ? 321 CYS A N   1 
ATOM 2029 C CA  . CYS A 1 321 ? 164.649 91.518  144.902 1.00 198.51 ? 321 CYS A CA  1 
ATOM 2030 C C   . CYS A 1 321 ? 163.636 92.659  144.855 1.00 196.54 ? 321 CYS A C   1 
ATOM 2031 O O   . CYS A 1 321 ? 162.703 92.686  145.668 1.00 195.19 ? 321 CYS A O   1 
ATOM 2032 C CB  . CYS A 1 321 ? 164.046 90.251  144.295 1.00 196.76 ? 321 CYS A CB  1 
ATOM 2033 S SG  . CYS A 1 321 ? 163.970 90.243  142.487 1.00 196.70 ? 321 CYS A SG  1 
ATOM 2034 N N   . PRO A 1 322 ? 163.784 93.615  143.940 1.00 179.56 ? 322 PRO A N   1 
ATOM 2035 C CA  . PRO A 1 322 ? 162.925 94.804  143.980 1.00 179.10 ? 322 PRO A CA  1 
ATOM 2036 C C   . PRO A 1 322 ? 161.599 94.631  143.259 1.00 180.13 ? 322 PRO A C   1 
ATOM 2037 O O   . PRO A 1 322 ? 160.871 95.610  143.071 1.00 181.31 ? 322 PRO A O   1 
ATOM 2038 C CB  . PRO A 1 322 ? 163.792 95.866  143.300 1.00 179.95 ? 322 PRO A CB  1 
ATOM 2039 C CG  . PRO A 1 322 ? 164.582 95.087  142.299 1.00 180.04 ? 322 PRO A CG  1 
ATOM 2040 C CD  . PRO A 1 322 ? 164.819 93.718  142.899 1.00 181.60 ? 322 PRO A CD  1 
ATOM 2041 N N   . ILE A 1 323 ? 161.264 93.413  142.844 1.00 157.93 ? 323 ILE A N   1 
ATOM 2042 C CA  . ILE A 1 323 ? 159.995 93.191  142.159 1.00 154.54 ? 323 ILE A CA  1 
ATOM 2043 C C   . ILE A 1 323 ? 158.952 92.697  143.151 1.00 157.04 ? 323 ILE A C   1 
ATOM 2044 O O   . ILE A 1 323 ? 158.747 91.488  143.308 1.00 157.16 ? 323 ILE A O   1 
ATOM 2045 C CB  . ILE A 1 323 ? 160.160 92.204  140.992 1.00 153.16 ? 323 ILE A CB  1 
ATOM 2046 C CG1 . ILE A 1 323 ? 161.462 92.483  140.244 1.00 153.75 ? 323 ILE A CG1 1 
ATOM 2047 C CG2 . ILE A 1 323 ? 158.973 92.296  140.052 1.00 155.00 ? 323 ILE A CG2 1 
ATOM 2048 C CD1 . ILE A 1 323 ? 161.465 93.803  139.503 1.00 155.47 ? 323 ILE A CD1 1 
ATOM 2049 N N   . ASN A 1 324 ? 158.287 93.632  143.831 1.00 156.66 ? 324 ASN A N   1 
ATOM 2050 C CA  . ASN A 1 324 ? 157.174 93.313  144.718 1.00 152.47 ? 324 ASN A CA  1 
ATOM 2051 C C   . ASN A 1 324 ? 156.062 94.332  144.529 1.00 153.82 ? 324 ASN A C   1 
ATOM 2052 O O   . ASN A 1 324 ? 156.144 95.194  143.650 1.00 162.85 ? 324 ASN A O   1 
ATOM 2053 C CB  . ASN A 1 324 ? 157.595 93.300  146.191 1.00 153.44 ? 324 ASN A CB  1 
ATOM 2054 C CG  . ASN A 1 324 ? 158.893 92.560  146.434 1.00 160.16 ? 324 ASN A CG  1 
ATOM 2055 O OD1 . ASN A 1 324 ? 159.936 92.912  145.891 1.00 164.12 ? 324 ASN A OD1 1 
ATOM 2056 N ND2 . ASN A 1 324 ? 158.835 91.527  147.265 1.00 163.40 ? 324 ASN A ND2 1 
ATOM 2057 N N   . ASP A 1 325 ? 155.021 94.244  145.352 1.00 148.62 ? 325 ASP A N   1 
ATOM 2058 C CA  . ASP A 1 325 ? 154.035 95.307  145.446 1.00 152.22 ? 325 ASP A CA  1 
ATOM 2059 C C   . ASP A 1 325 ? 154.487 96.424  146.367 1.00 153.35 ? 325 ASP A C   1 
ATOM 2060 O O   . ASP A 1 325 ? 153.816 97.456  146.449 1.00 157.26 ? 325 ASP A O   1 
ATOM 2061 C CB  . ASP A 1 325 ? 152.699 94.750  145.945 1.00 158.43 ? 325 ASP A CB  1 
ATOM 2062 C CG  . ASP A 1 325 ? 152.233 93.561  145.139 1.00 161.11 ? 325 ASP A CG  1 
ATOM 2063 O OD1 . ASP A 1 325 ? 152.928 92.533  145.182 1.00 161.51 ? 325 ASP A OD1 1 
ATOM 2064 O OD2 . ASP A 1 325 ? 151.175 93.633  144.485 1.00 158.03 ? 325 ASP A OD2 1 
ATOM 2065 N N   . LEU A 1 326 ? 155.604 96.235  147.072 1.00 147.18 ? 326 LEU A N   1 
ATOM 2066 C CA  . LEU A 1 326 ? 156.114 97.272  147.957 1.00 152.36 ? 326 LEU A CA  1 
ATOM 2067 C C   . LEU A 1 326 ? 156.679 98.449  147.174 1.00 153.29 ? 326 LEU A C   1 
ATOM 2068 O O   . LEU A 1 326 ? 156.529 99.601  147.597 1.00 149.89 ? 326 LEU A O   1 
ATOM 2069 C CB  . LEU A 1 326 ? 157.182 96.686  148.879 1.00 148.81 ? 326 LEU A CB  1 
ATOM 2070 C CG  . LEU A 1 326 ? 157.530 97.450  150.155 1.00 146.78 ? 326 LEU A CG  1 
ATOM 2071 C CD1 . LEU A 1 326 ? 156.324 98.191  150.701 1.00 146.18 ? 326 LEU A CD1 1 
ATOM 2072 C CD2 . LEU A 1 326 ? 158.088 96.497  151.194 1.00 151.20 ? 326 LEU A CD2 1 
ATOM 2073 N N   . ASN A 1 327 ? 157.333 98.182  146.043 1.00 146.36 ? 327 ASN A N   1 
ATOM 2074 C CA  . ASN A 1 327 ? 157.971 99.253  145.286 1.00 141.69 ? 327 ASN A CA  1 
ATOM 2075 C C   . ASN A 1 327 ? 156.951 100.237 144.731 1.00 141.61 ? 327 ASN A C   1 
ATOM 2076 O O   . ASN A 1 327 ? 157.162 101.453 144.788 1.00 150.56 ? 327 ASN A O   1 
ATOM 2077 C CB  . ASN A 1 327 ? 158.817 98.666  144.161 1.00 143.64 ? 327 ASN A CB  1 
ATOM 2078 C CG  . ASN A 1 327 ? 160.295 98.723  144.464 1.00 149.49 ? 327 ASN A CG  1 
ATOM 2079 O OD1 . ASN A 1 327 ? 160.790 99.713  144.998 1.00 152.52 ? 327 ASN A OD1 1 
ATOM 2080 N ND2 . ASN A 1 327 ? 161.010 97.657  144.128 1.00 152.38 ? 327 ASN A ND2 1 
ATOM 2081 N N   . VAL A 1 328 ? 155.835 99.736  144.198 1.00 120.03 ? 328 VAL A N   1 
ATOM 2082 C CA  . VAL A 1 328 ? 154.850 100.630 143.598 1.00 128.93 ? 328 VAL A CA  1 
ATOM 2083 C C   . VAL A 1 328 ? 154.170 101.483 144.665 1.00 136.55 ? 328 VAL A C   1 
ATOM 2084 O O   . VAL A 1 328 ? 153.952 102.686 144.467 1.00 141.74 ? 328 VAL A O   1 
ATOM 2085 C CB  . VAL A 1 328 ? 153.842 99.825  142.754 1.00 126.23 ? 328 VAL A CB  1 
ATOM 2086 C CG1 . VAL A 1 328 ? 153.218 98.711  143.564 1.00 128.20 ? 328 VAL A CG1 1 
ATOM 2087 C CG2 . VAL A 1 328 ? 152.767 100.739 142.194 1.00 134.36 ? 328 VAL A CG2 1 
ATOM 2088 N N   . ILE A 1 329 ? 153.847 100.894 145.819 1.00 141.45 ? 329 ILE A N   1 
ATOM 2089 C CA  . ILE A 1 329 ? 153.211 101.695 146.860 1.00 143.99 ? 329 ILE A CA  1 
ATOM 2090 C C   . ILE A 1 329 ? 154.207 102.675 147.461 1.00 143.17 ? 329 ILE A C   1 
ATOM 2091 O O   . ILE A 1 329 ? 153.828 103.782 147.856 1.00 143.05 ? 329 ILE A O   1 
ATOM 2092 C CB  . ILE A 1 329 ? 152.558 100.806 147.935 1.00 136.58 ? 329 ILE A CB  1 
ATOM 2093 C CG1 . ILE A 1 329 ? 153.575 99.873  148.585 1.00 136.09 ? 329 ILE A CG1 1 
ATOM 2094 C CG2 . ILE A 1 329 ? 151.408 100.013 147.333 1.00 142.47 ? 329 ILE A CG2 1 
ATOM 2095 C CD1 . ILE A 1 329 ? 152.950 98.769  149.407 1.00 142.17 ? 329 ILE A CD1 1 
ATOM 2096 N N   . LEU A 1 330 ? 155.494 102.318 147.516 1.00 135.10 ? 330 LEU A N   1 
ATOM 2097 C CA  . LEU A 1 330 ? 156.501 103.280 147.951 1.00 131.99 ? 330 LEU A CA  1 
ATOM 2098 C C   . LEU A 1 330 ? 156.616 104.440 146.971 1.00 135.10 ? 330 LEU A C   1 
ATOM 2099 O O   . LEU A 1 330 ? 156.753 105.598 147.385 1.00 135.53 ? 330 LEU A O   1 
ATOM 2100 C CB  . LEU A 1 330 ? 157.850 102.587 148.121 1.00 134.89 ? 330 LEU A CB  1 
ATOM 2101 C CG  . LEU A 1 330 ? 158.353 102.490 149.560 1.00 137.82 ? 330 LEU A CG  1 
ATOM 2102 C CD1 . LEU A 1 330 ? 157.345 101.751 150.419 1.00 136.83 ? 330 LEU A CD1 1 
ATOM 2103 C CD2 . LEU A 1 330 ? 159.707 101.802 149.607 1.00 140.77 ? 330 LEU A CD2 1 
ATOM 2104 N N   . LEU A 1 331 ? 156.570 104.149 145.669 1.00 144.19 ? 331 LEU A N   1 
ATOM 2105 C CA  . LEU A 1 331 ? 156.619 105.209 144.669 1.00 141.40 ? 331 LEU A CA  1 
ATOM 2106 C C   . LEU A 1 331 ? 155.420 106.138 144.794 1.00 140.78 ? 331 LEU A C   1 
ATOM 2107 O O   . LEU A 1 331 ? 155.563 107.364 144.730 1.00 148.15 ? 331 LEU A O   1 
ATOM 2108 C CB  . LEU A 1 331 ? 156.677 104.609 143.267 1.00 137.25 ? 331 LEU A CB  1 
ATOM 2109 C CG  . LEU A 1 331 ? 158.008 103.989 142.847 1.00 146.67 ? 331 LEU A CG  1 
ATOM 2110 C CD1 . LEU A 1 331 ? 157.988 103.669 141.365 1.00 145.40 ? 331 LEU A CD1 1 
ATOM 2111 C CD2 . LEU A 1 331 ? 159.164 104.916 143.186 1.00 146.38 ? 331 LEU A CD2 1 
ATOM 2112 N N   . PHE A 1 332 ? 154.227 105.570 144.978 1.00 144.79 ? 332 PHE A N   1 
ATOM 2113 C CA  . PHE A 1 332 ? 153.041 106.407 145.122 1.00 148.08 ? 332 PHE A CA  1 
ATOM 2114 C C   . PHE A 1 332 ? 153.057 107.190 146.429 1.00 154.70 ? 332 PHE A C   1 
ATOM 2115 O O   . PHE A 1 332 ? 152.543 108.312 146.480 1.00 157.08 ? 332 PHE A O   1 
ATOM 2116 C CB  . PHE A 1 332 ? 151.779 105.558 145.014 1.00 147.25 ? 332 PHE A CB  1 
ATOM 2117 C CG  . PHE A 1 332 ? 151.326 105.336 143.603 1.00 146.56 ? 332 PHE A CG  1 
ATOM 2118 C CD1 . PHE A 1 332 ? 150.515 106.261 142.972 1.00 149.65 ? 332 PHE A CD1 1 
ATOM 2119 C CD2 . PHE A 1 332 ? 151.718 104.210 142.904 1.00 149.18 ? 332 PHE A CD2 1 
ATOM 2120 C CE1 . PHE A 1 332 ? 150.100 106.063 141.673 1.00 154.07 ? 332 PHE A CE1 1 
ATOM 2121 C CE2 . PHE A 1 332 ? 151.306 104.007 141.605 1.00 153.88 ? 332 PHE A CE2 1 
ATOM 2122 C CZ  . PHE A 1 332 ? 150.496 104.935 140.989 1.00 156.05 ? 332 PHE A CZ  1 
ATOM 2123 N N   . LEU A 1 333 ? 153.633 106.619 147.489 1.00 148.77 ? 333 LEU A N   1 
ATOM 2124 C CA  . LEU A 1 333 ? 153.789 107.361 148.734 1.00 144.93 ? 333 LEU A CA  1 
ATOM 2125 C C   . LEU A 1 333 ? 154.734 108.540 148.555 1.00 147.03 ? 333 LEU A C   1 
ATOM 2126 O O   . LEU A 1 333 ? 154.460 109.644 149.038 1.00 146.71 ? 333 LEU A O   1 
ATOM 2127 C CB  . LEU A 1 333 ? 154.301 106.430 149.831 1.00 140.82 ? 333 LEU A CB  1 
ATOM 2128 C CG  . LEU A 1 333 ? 153.710 106.625 151.224 1.00 146.24 ? 333 LEU A CG  1 
ATOM 2129 C CD1 . LEU A 1 333 ? 152.197 106.593 151.157 1.00 147.91 ? 333 LEU A CD1 1 
ATOM 2130 C CD2 . LEU A 1 333 ? 154.229 105.559 152.171 1.00 149.64 ? 333 LEU A CD2 1 
ATOM 2131 N N   . ARG A 1 334 ? 155.852 108.322 147.860 1.00 162.33 ? 334 ARG A N   1 
ATOM 2132 C CA  . ARG A 1 334 ? 156.800 109.403 147.619 1.00 161.88 ? 334 ARG A CA  1 
ATOM 2133 C C   . ARG A 1 334 ? 156.188 110.487 146.743 1.00 161.27 ? 334 ARG A C   1 
ATOM 2134 O O   . ARG A 1 334 ? 156.421 111.681 146.969 1.00 160.69 ? 334 ARG A O   1 
ATOM 2135 C CB  . ARG A 1 334 ? 158.074 108.852 146.983 1.00 160.87 ? 334 ARG A CB  1 
ATOM 2136 C CG  . ARG A 1 334 ? 159.333 109.621 147.345 1.00 162.34 ? 334 ARG A CG  1 
ATOM 2137 C CD  . ARG A 1 334 ? 159.627 110.708 146.324 1.00 164.64 ? 334 ARG A CD  1 
ATOM 2138 N NE  . ARG A 1 334 ? 159.777 110.163 144.980 1.00 168.03 ? 334 ARG A NE  1 
ATOM 2139 C CZ  . ARG A 1 334 ? 160.928 109.757 144.463 1.00 170.39 ? 334 ARG A CZ  1 
ATOM 2140 N NH1 . ARG A 1 334 ? 162.057 109.821 145.150 1.00 168.88 ? 334 ARG A NH1 1 
ATOM 2141 N NH2 . ARG A 1 334 ? 160.947 109.275 143.223 1.00 168.59 ? 334 ARG A NH2 1 
ATOM 2142 N N   . ALA A 1 335 ? 155.404 110.095 145.740 1.00 155.96 ? 335 ALA A N   1 
ATOM 2143 C CA  . ALA A 1 335 ? 154.749 111.075 144.884 1.00 154.68 ? 335 ALA A CA  1 
ATOM 2144 C C   . ALA A 1 335 ? 153.596 111.787 145.575 1.00 154.05 ? 335 ALA A C   1 
ATOM 2145 O O   . ALA A 1 335 ? 153.119 112.801 145.054 1.00 155.37 ? 335 ALA A O   1 
ATOM 2146 C CB  . ALA A 1 335 ? 154.248 110.405 143.605 1.00 156.75 ? 335 ALA A CB  1 
ATOM 2147 N N   . ASN A 1 336 ? 153.135 111.290 146.719 1.00 160.55 ? 336 ASN A N   1 
ATOM 2148 C CA  . ASN A 1 336 ? 152.042 111.895 147.466 1.00 161.85 ? 336 ASN A CA  1 
ATOM 2149 C C   . ASN A 1 336 ? 152.493 112.282 148.869 1.00 164.90 ? 336 ASN A C   1 
ATOM 2150 O O   . ASN A 1 336 ? 151.757 112.129 149.845 1.00 168.12 ? 336 ASN A O   1 
ATOM 2151 C CB  . ASN A 1 336 ? 150.840 110.956 147.528 1.00 161.15 ? 336 ASN A CB  1 
ATOM 2152 C CG  . ASN A 1 336 ? 149.878 111.171 146.380 1.00 164.10 ? 336 ASN A CG  1 
ATOM 2153 O OD1 . ASN A 1 336 ? 148.676 110.950 146.513 1.00 163.67 ? 336 ASN A OD1 1 
ATOM 2154 N ND2 . ASN A 1 336 ? 150.405 111.601 145.242 1.00 167.02 ? 336 ASN A ND2 1 
ATOM 2155 N N   . ILE A 1 337 ? 153.721 112.791 148.979 1.00 172.94 ? 337 ILE A N   1 
ATOM 2156 C CA  . ILE A 1 337 ? 154.269 113.157 150.279 1.00 168.96 ? 337 ILE A CA  1 
ATOM 2157 C C   . ILE A 1 337 ? 153.562 114.368 150.871 1.00 169.37 ? 337 ILE A C   1 
ATOM 2158 O O   . ILE A 1 337 ? 153.609 114.577 152.088 1.00 170.99 ? 337 ILE A O   1 
ATOM 2159 C CB  . ILE A 1 337 ? 155.786 113.401 150.160 1.00 172.50 ? 337 ILE A CB  1 
ATOM 2160 C CG1 . ILE A 1 337 ? 156.468 113.295 151.525 1.00 174.91 ? 337 ILE A CG1 1 
ATOM 2161 C CG2 . ILE A 1 337 ? 156.072 114.753 149.522 1.00 172.38 ? 337 ILE A CG2 1 
ATOM 2162 C CD1 . ILE A 1 337 ? 156.046 112.086 152.325 1.00 176.67 ? 337 ILE A CD1 1 
ATOM 2163 N N   . SER A 1 338 ? 152.887 115.170 150.043 1.00 199.80 ? 338 SER A N   1 
ATOM 2164 C CA  . SER A 1 338 ? 152.266 116.398 150.518 1.00 204.39 ? 338 SER A CA  1 
ATOM 2165 C C   . SER A 1 338 ? 151.012 116.157 151.349 1.00 208.51 ? 338 SER A C   1 
ATOM 2166 O O   . SER A 1 338 ? 150.538 117.094 151.998 1.00 210.44 ? 338 SER A O   1 
ATOM 2167 C CB  . SER A 1 338 ? 151.925 117.301 149.332 1.00 204.76 ? 338 SER A CB  1 
ATOM 2168 O OG  . SER A 1 338 ? 151.129 118.398 149.742 1.00 206.95 ? 338 SER A OG  1 
ATOM 2169 N N   . GLU A 1 339 ? 150.465 114.940 151.341 1.00 235.54 ? 339 GLU A N   1 
ATOM 2170 C CA  . GLU A 1 339 ? 149.236 114.683 152.085 1.00 236.74 ? 339 GLU A CA  1 
ATOM 2171 C C   . GLU A 1 339 ? 149.482 114.702 153.589 1.00 235.94 ? 339 GLU A C   1 
ATOM 2172 O O   . GLU A 1 339 ? 148.729 115.330 154.343 1.00 238.60 ? 339 GLU A O   1 
ATOM 2173 C CB  . GLU A 1 339 ? 148.631 113.347 151.655 1.00 237.71 ? 339 GLU A CB  1 
ATOM 2174 C CG  . GLU A 1 339 ? 147.614 113.468 150.535 1.00 240.04 ? 339 GLU A CG  1 
ATOM 2175 C CD  . GLU A 1 339 ? 146.505 114.452 150.855 1.00 239.61 ? 339 GLU A CD  1 
ATOM 2176 O OE1 . GLU A 1 339 ? 145.582 114.083 151.611 1.00 241.44 ? 339 GLU A OE1 1 
ATOM 2177 O OE2 . GLU A 1 339 ? 146.555 115.593 150.349 1.00 238.53 ? 339 GLU A OE2 1 
ATOM 2178 N N   . LEU A 1 340 ? 150.529 114.023 154.044 1.00 204.21 ? 340 LEU A N   1 
ATOM 2179 C CA  . LEU A 1 340 ? 150.842 113.981 155.463 1.00 205.65 ? 340 LEU A CA  1 
ATOM 2180 C C   . LEU A 1 340 ? 151.714 115.174 155.843 1.00 206.49 ? 340 LEU A C   1 
ATOM 2181 O O   . LEU A 1 340 ? 152.002 116.056 155.031 1.00 205.64 ? 340 LEU A O   1 
ATOM 2182 C CB  . LEU A 1 340 ? 151.518 112.660 155.822 1.00 205.18 ? 340 LEU A CB  1 
ATOM 2183 C CG  . LEU A 1 340 ? 152.915 112.428 155.250 1.00 205.59 ? 340 LEU A CG  1 
ATOM 2184 C CD1 . LEU A 1 340 ? 153.826 111.811 156.298 1.00 205.30 ? 340 LEU A CD1 1 
ATOM 2185 C CD2 . LEU A 1 340 ? 152.836 111.544 154.020 1.00 205.53 ? 340 LEU A CD2 1 
ATOM 2186 N N   . ILE A 1 341 ? 152.142 115.205 157.104 1.00 204.37 ? 341 ILE A N   1 
ATOM 2187 C CA  . ILE A 1 341 ? 152.939 116.310 157.620 1.00 203.91 ? 341 ILE A CA  1 
ATOM 2188 C C   . ILE A 1 341 ? 154.373 116.172 157.129 1.00 203.87 ? 341 ILE A C   1 
ATOM 2189 O O   . ILE A 1 341 ? 155.154 115.378 157.662 1.00 201.32 ? 341 ILE A O   1 
ATOM 2190 C CB  . ILE A 1 341 ? 152.884 116.366 159.157 1.00 203.26 ? 341 ILE A CB  1 
ATOM 2191 C CG1 . ILE A 1 341 ? 151.432 116.433 159.640 1.00 201.51 ? 341 ILE A CG1 1 
ATOM 2192 C CG2 . ILE A 1 341 ? 153.677 117.555 159.675 1.00 204.26 ? 341 ILE A CG2 1 
ATOM 2193 C CD1 . ILE A 1 341 ? 150.615 117.528 158.988 1.00 200.20 ? 341 ILE A CD1 1 
ATOM 2194 N N   . SER A 1 342 ? 154.726 116.947 156.104 1.00 217.58 ? 342 SER A N   1 
ATOM 2195 C CA  . SER A 1 342 ? 156.062 116.933 155.522 1.00 217.70 ? 342 SER A CA  1 
ATOM 2196 C C   . SER A 1 342 ? 156.887 118.136 155.964 1.00 217.26 ? 342 SER A C   1 
ATOM 2197 O O   . SER A 1 342 ? 157.722 118.636 155.207 1.00 215.20 ? 342 SER A O   1 
ATOM 2198 C CB  . SER A 1 342 ? 155.977 116.881 153.997 1.00 218.16 ? 342 SER A CB  1 
ATOM 2199 O OG  . SER A 1 342 ? 155.802 118.179 153.456 1.00 217.33 ? 342 SER A OG  1 
ATOM 2200 N N   . PHE A 1 343 ? 156.651 118.617 157.189 1.00 221.18 ? 343 PHE A N   1 
ATOM 2201 C CA  . PHE A 1 343 ? 157.402 119.762 157.694 1.00 221.67 ? 343 PHE A CA  1 
ATOM 2202 C C   . PHE A 1 343 ? 158.885 119.438 157.822 1.00 221.37 ? 343 PHE A C   1 
ATOM 2203 O O   . PHE A 1 343 ? 159.741 120.250 157.452 1.00 221.27 ? 343 PHE A O   1 
ATOM 2204 C CB  . PHE A 1 343 ? 156.832 120.210 159.039 1.00 220.44 ? 343 PHE A CB  1 
ATOM 2205 N N   . SER A 1 344 ? 159.208 118.254 158.340 1.00 214.26 ? 344 SER A N   1 
ATOM 2206 C CA  . SER A 1 344 ? 160.598 117.839 158.466 1.00 214.75 ? 344 SER A CA  1 
ATOM 2207 C C   . SER A 1 344 ? 161.188 117.337 157.156 1.00 213.90 ? 344 SER A C   1 
ATOM 2208 O O   . SER A 1 344 ? 162.411 117.188 157.064 1.00 214.37 ? 344 SER A O   1 
ATOM 2209 C CB  . SER A 1 344 ? 160.726 116.751 159.536 1.00 213.81 ? 344 SER A CB  1 
ATOM 2210 N N   . TRP A 1 345 ? 160.353 117.074 156.148 1.00 222.24 ? 345 TRP A N   1 
ATOM 2211 C CA  . TRP A 1 345 ? 160.864 116.586 154.872 1.00 224.64 ? 345 TRP A CA  1 
ATOM 2212 C C   . TRP A 1 345 ? 161.604 117.682 154.114 1.00 225.26 ? 345 TRP A C   1 
ATOM 2213 O O   . TRP A 1 345 ? 162.609 117.413 153.445 1.00 225.16 ? 345 TRP A O   1 
ATOM 2214 C CB  . TRP A 1 345 ? 159.720 116.029 154.028 1.00 224.21 ? 345 TRP A CB  1 
ATOM 2215 N N   . LEU A 1 346 ? 161.125 118.922 154.206 1.00 209.19 ? 346 LEU A N   1 
ATOM 2216 C CA  . LEU A 1 346 ? 161.708 120.022 153.450 1.00 206.75 ? 346 LEU A CA  1 
ATOM 2217 C C   . LEU A 1 346 ? 163.018 120.530 154.036 1.00 207.17 ? 346 LEU A C   1 
ATOM 2218 O O   . LEU A 1 346 ? 163.706 121.315 153.376 1.00 206.40 ? 346 LEU A O   1 
ATOM 2219 C CB  . LEU A 1 346 ? 160.709 121.179 153.358 1.00 203.78 ? 346 LEU A CB  1 
ATOM 2220 N N   . SER A 1 347 ? 163.385 120.105 155.244 1.00 198.05 ? 347 SER A N   1 
ATOM 2221 C CA  . SER A 1 347 ? 164.593 120.583 155.914 1.00 197.03 ? 347 SER A CA  1 
ATOM 2222 C C   . SER A 1 347 ? 165.717 119.557 155.871 1.00 197.11 ? 347 SER A C   1 
ATOM 2223 O O   . SER A 1 347 ? 166.497 119.438 156.820 1.00 194.71 ? 347 SER A O   1 
ATOM 2224 C CB  . SER A 1 347 ? 164.276 120.970 157.355 1.00 196.78 ? 347 SER A CB  1 
ATOM 2225 N N   . VAL A 1 348 ? 165.824 118.803 154.783 1.00 189.88 ? 348 VAL A N   1 
ATOM 2226 C CA  . VAL A 1 348 ? 166.869 117.796 154.651 1.00 189.05 ? 348 VAL A CA  1 
ATOM 2227 C C   . VAL A 1 348 ? 168.221 118.462 154.429 1.00 186.49 ? 348 VAL A C   1 
ATOM 2228 O O   . VAL A 1 348 ? 168.954 118.732 155.380 1.00 183.35 ? 348 VAL A O   1 
ATOM 2229 C CB  . VAL A 1 348 ? 166.553 116.812 153.510 1.00 189.24 ? 348 VAL A CB  1 
ATOM 2230 N N   . ASP A 1 367 ? 170.219 117.973 169.020 1.00 190.59 ? 367 ASP A N   1 
ATOM 2231 C CA  . ASP A 1 367 ? 170.584 118.082 167.612 1.00 191.54 ? 367 ASP A CA  1 
ATOM 2232 C C   . ASP A 1 367 ? 169.364 117.893 166.718 1.00 193.66 ? 367 ASP A C   1 
ATOM 2233 O O   . ASP A 1 367 ? 168.566 118.815 166.542 1.00 193.46 ? 367 ASP A O   1 
ATOM 2234 C CB  . ASP A 1 367 ? 171.662 117.055 167.257 1.00 187.91 ? 367 ASP A CB  1 
ATOM 2235 N N   . PHE A 1 368 ? 169.233 116.693 166.149 1.00 206.99 ? 368 PHE A N   1 
ATOM 2236 C CA  . PHE A 1 368 ? 168.080 116.392 165.307 1.00 206.88 ? 368 PHE A CA  1 
ATOM 2237 C C   . PHE A 1 368 ? 166.786 116.440 166.109 1.00 207.92 ? 368 PHE A C   1 
ATOM 2238 O O   . PHE A 1 368 ? 165.765 116.944 165.624 1.00 206.48 ? 368 PHE A O   1 
ATOM 2239 C CB  . PHE A 1 368 ? 168.254 115.021 164.650 1.00 202.55 ? 368 PHE A CB  1 
ATOM 2240 N N   . MET A 1 369 ? 166.809 115.917 167.335 1.00 211.24 ? 369 MET A N   1 
ATOM 2241 C CA  . MET A 1 369 ? 165.631 115.987 168.195 1.00 211.41 ? 369 MET A CA  1 
ATOM 2242 C C   . MET A 1 369 ? 165.302 117.427 168.562 1.00 211.16 ? 369 MET A C   1 
ATOM 2243 O O   . MET A 1 369 ? 164.125 117.799 168.649 1.00 209.17 ? 369 MET A O   1 
ATOM 2244 C CB  . MET A 1 369 ? 165.848 115.147 169.452 1.00 211.23 ? 369 MET A CB  1 
ATOM 2245 N N   . THR A 1 370 ? 166.327 118.251 168.790 1.00 193.40 ? 370 THR A N   1 
ATOM 2246 C CA  . THR A 1 370 ? 166.094 119.661 169.090 1.00 190.83 ? 370 THR A CA  1 
ATOM 2247 C C   . THR A 1 370 ? 165.429 120.369 167.916 1.00 192.09 ? 370 THR A C   1 
ATOM 2248 O O   . THR A 1 370 ? 164.523 121.189 168.109 1.00 190.75 ? 370 THR A O   1 
ATOM 2249 C CB  . THR A 1 370 ? 167.411 120.348 169.450 1.00 187.72 ? 370 THR A CB  1 
ATOM 2250 N N   . LEU A 1 371 ? 165.869 120.069 166.694 1.00 194.76 ? 371 LEU A N   1 
ATOM 2251 C CA  . LEU A 1 371 ? 165.227 120.638 165.514 1.00 192.87 ? 371 LEU A CA  1 
ATOM 2252 C C   . LEU A 1 371 ? 163.798 120.133 165.363 1.00 192.70 ? 371 LEU A C   1 
ATOM 2253 O O   . LEU A 1 371 ? 162.893 120.903 165.025 1.00 195.27 ? 371 LEU A O   1 
ATOM 2254 C CB  . LEU A 1 371 ? 166.046 120.317 164.264 1.00 191.26 ? 371 LEU A CB  1 
ATOM 2255 N N   . LEU A 1 372 ? 163.576 118.842 165.615 1.00 186.32 ? 372 LEU A N   1 
ATOM 2256 C CA  . LEU A 1 372 ? 162.246 118.260 165.482 1.00 186.67 ? 372 LEU A CA  1 
ATOM 2257 C C   . LEU A 1 372 ? 161.314 118.641 166.623 1.00 188.44 ? 372 LEU A C   1 
ATOM 2258 O O   . LEU A 1 372 ? 160.117 118.342 166.543 1.00 188.88 ? 372 LEU A O   1 
ATOM 2259 C CB  . LEU A 1 372 ? 162.348 116.737 165.388 1.00 185.83 ? 372 LEU A CB  1 
ATOM 2260 N N   . ALA A 1 373 ? 161.830 119.276 167.679 1.00 193.49 ? 373 ALA A N   1 
ATOM 2261 C CA  . ALA A 1 373 ? 160.984 119.666 168.803 1.00 194.74 ? 373 ALA A CA  1 
ATOM 2262 C C   . ALA A 1 373 ? 159.925 120.675 168.380 1.00 194.77 ? 373 ALA A C   1 
ATOM 2263 O O   . ALA A 1 373 ? 158.775 120.606 168.832 1.00 193.61 ? 373 ALA A O   1 
ATOM 2264 C CB  . ALA A 1 373 ? 161.844 120.231 169.933 1.00 192.15 ? 373 ALA A CB  1 
ATOM 2265 N N   . GLY A 1 374 ? 160.290 121.620 167.521 1.00 181.47 ? 374 GLY A N   1 
ATOM 2266 C CA  . GLY A 1 374 ? 159.350 122.616 167.042 1.00 180.92 ? 374 GLY A CA  1 
ATOM 2267 C C   . GLY A 1 374 ? 158.292 122.046 166.118 1.00 178.03 ? 374 GLY A C   1 
ATOM 2268 O O   . GLY A 1 374 ? 157.227 121.622 166.567 1.00 176.60 ? 374 GLY A O   1 
# 
