data_9KPL
# 
_entry.id   9KPL 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9KPL         pdb_00009kpl 10.2210/pdb9kpl/pdb 
WWPDB D_1300054046 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9KPL 
_pdbx_database_status.recvd_initial_deposition_date   2024-11-23 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              yamasaki@biken.osaka-u.ac.jp 
_pdbx_contact_author.name_first         Sho 
_pdbx_contact_author.name_last          Yamasaki 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-5184-6917 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Ito, T.'      1 ? 
'Nagae, M.'    2 ? 
'Yamasaki, S.' 3 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Immunogenetics 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           0093-7711 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            77 
_citation.language                  ? 
_citation.page_first                18 
_citation.page_last                 18 
_citation.title                     'Phylogenetic and structural insights into the origin of C-type lectin Mincle in vertebrates.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1007/s00251-025-01375-x 
_citation.pdbx_database_id_PubMed   40119899 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Ito, T.'      1 0000-0002-1408-7288 
primary 'Guenther, C.' 2 0000-0001-7915-1028 
primary 'Ishikawa, E.' 3 0000-0002-4922-6751 
primary 'Yabuki, T.'   4 ?                   
primary 'Nagae, M.'    5 0000-0002-5470-3807 
primary 'Nakatani, Y.' 6 0000-0001-7604-0242 
primary 'Yamasaki, S.' 7 0000-0002-5184-6917 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'C-type lectin domain-containing protein' 17412.408 2   ? ? ? 
'The sequence matches with Gene ID 105419054 (XP_029706534.1)' 
2 non-polymer syn alpha-D-glucopyranose                     180.156   2   ? ? ? ? 
3 non-polymer syn beta-D-glucopyranose                      180.156   2   ? ? ? ? 
4 non-polymer syn 'CALCIUM ION'                             40.078    4   ? ? ? ? 
5 water       nat water                                     18.015    181 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MNGTAEERNKFDKLDPYFQQGWFHFQKSLYYISSVKNTWHLSREYCLQEGADLAIINSRAEQAFLENFKMTLWIGLMEQR
SERTWRWVDGTPLTESYWSLGEPNNYEGRQEQCVEQIDREDKKGWNDLVCEFSNFYMCEKRIFP
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MNGTAEERNKFDKLDPYFQQGWFHFQKSLYYISSVKNTWHLSREYCLQEGADLAIINSRAEQAFLENFKMTLWIGLMEQR
SERTWRWVDGTPLTESYWSLGEPNNYEGRQEQCVEQIDREDKKGWNDLVCEFSNFYMCEKRIFP
;
_entity_poly.pdbx_strand_id                 A,E 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 alpha-D-glucopyranose GLC 
3 beta-D-glucopyranose  BGC 
4 'CALCIUM ION'         CA  
5 water                 HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ASN n 
1 3   GLY n 
1 4   THR n 
1 5   ALA n 
1 6   GLU n 
1 7   GLU n 
1 8   ARG n 
1 9   ASN n 
1 10  LYS n 
1 11  PHE n 
1 12  ASP n 
1 13  LYS n 
1 14  LEU n 
1 15  ASP n 
1 16  PRO n 
1 17  TYR n 
1 18  PHE n 
1 19  GLN n 
1 20  GLN n 
1 21  GLY n 
1 22  TRP n 
1 23  PHE n 
1 24  HIS n 
1 25  PHE n 
1 26  GLN n 
1 27  LYS n 
1 28  SER n 
1 29  LEU n 
1 30  TYR n 
1 31  TYR n 
1 32  ILE n 
1 33  SER n 
1 34  SER n 
1 35  VAL n 
1 36  LYS n 
1 37  ASN n 
1 38  THR n 
1 39  TRP n 
1 40  HIS n 
1 41  LEU n 
1 42  SER n 
1 43  ARG n 
1 44  GLU n 
1 45  TYR n 
1 46  CYS n 
1 47  LEU n 
1 48  GLN n 
1 49  GLU n 
1 50  GLY n 
1 51  ALA n 
1 52  ASP n 
1 53  LEU n 
1 54  ALA n 
1 55  ILE n 
1 56  ILE n 
1 57  ASN n 
1 58  SER n 
1 59  ARG n 
1 60  ALA n 
1 61  GLU n 
1 62  GLN n 
1 63  ALA n 
1 64  PHE n 
1 65  LEU n 
1 66  GLU n 
1 67  ASN n 
1 68  PHE n 
1 69  LYS n 
1 70  MET n 
1 71  THR n 
1 72  LEU n 
1 73  TRP n 
1 74  ILE n 
1 75  GLY n 
1 76  LEU n 
1 77  MET n 
1 78  GLU n 
1 79  GLN n 
1 80  ARG n 
1 81  SER n 
1 82  GLU n 
1 83  ARG n 
1 84  THR n 
1 85  TRP n 
1 86  ARG n 
1 87  TRP n 
1 88  VAL n 
1 89  ASP n 
1 90  GLY n 
1 91  THR n 
1 92  PRO n 
1 93  LEU n 
1 94  THR n 
1 95  GLU n 
1 96  SER n 
1 97  TYR n 
1 98  TRP n 
1 99  SER n 
1 100 LEU n 
1 101 GLY n 
1 102 GLU n 
1 103 PRO n 
1 104 ASN n 
1 105 ASN n 
1 106 TYR n 
1 107 GLU n 
1 108 GLY n 
1 109 ARG n 
1 110 GLN n 
1 111 GLU n 
1 112 GLN n 
1 113 CYS n 
1 114 VAL n 
1 115 GLU n 
1 116 GLN n 
1 117 ILE n 
1 118 ASP n 
1 119 ARG n 
1 120 GLU n 
1 121 ASP n 
1 122 LYS n 
1 123 LYS n 
1 124 GLY n 
1 125 TRP n 
1 126 ASN n 
1 127 ASP n 
1 128 LEU n 
1 129 VAL n 
1 130 CYS n 
1 131 GLU n 
1 132 PHE n 
1 133 SER n 
1 134 ASN n 
1 135 PHE n 
1 136 TYR n 
1 137 MET n 
1 138 CYS n 
1 139 GLU n 
1 140 LYS n 
1 141 ARG n 
1 142 ILE n 
1 143 PHE n 
1 144 PRO n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   144 
_entity_src_gen.gene_src_common_name               torafugu 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Takifugu rubripes' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     31033 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'           y ALANINE               ?                                     'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'           y ARGININE              ?                                     'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'           y ASPARAGINE            ?                                     'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'           y 'ASPARTIC ACID'       ?                                     'C4 H7 N O4'     133.103 
BGC 'D-saccharide, beta linking'  . beta-D-glucopyranose  'beta-D-glucose; D-glucose; glucose'  'C6 H12 O6'      180.156 
CA  non-polymer                   . 'CALCIUM ION'         ?                                     'Ca 2'           40.078  
CYS 'L-peptide linking'           y CYSTEINE              ?                                     'C3 H7 N O2 S'   121.158 
GLC 'D-saccharide, alpha linking' . alpha-D-glucopyranose 'alpha-D-glucose; D-glucose; glucose' 'C6 H12 O6'      180.156 
GLN 'L-peptide linking'           y GLUTAMINE             ?                                     'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'           y 'GLUTAMIC ACID'       ?                                     'C5 H9 N O4'     147.129 
GLY 'peptide linking'             y GLYCINE               ?                                     'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'           y HISTIDINE             ?                                     'C6 H10 N3 O2 1' 156.162 
HOH non-polymer                   . WATER                 ?                                     'H2 O'           18.015  
ILE 'L-peptide linking'           y ISOLEUCINE            ?                                     'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'           y LEUCINE               ?                                     'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'           y LYSINE                ?                                     'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'           y METHIONINE            ?                                     'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking'           y PHENYLALANINE         ?                                     'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'           y PROLINE               ?                                     'C5 H9 N O2'     115.130 
SER 'L-peptide linking'           y SERINE                ?                                     'C3 H7 N O3'     105.093 
THR 'L-peptide linking'           y THREONINE             ?                                     'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'           y TRYPTOPHAN            ?                                     'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'           y TYROSINE              ?                                     'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'           y VALINE                ?                                     'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
BGC 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpb            
BGC 'COMMON NAME'                         GMML     1.0 b-D-glucopyranose 
BGC 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-Glcp          
BGC 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 Glc               
GLC 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpa            
GLC 'COMMON NAME'                         GMML     1.0 a-D-glucopyranose 
GLC 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 a-D-Glcp          
GLC 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 Glc               
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   37  ?   ?   ?   A . n 
A 1 2   ASN 2   38  ?   ?   ?   A . n 
A 1 3   GLY 3   39  ?   ?   ?   A . n 
A 1 4   THR 4   40  ?   ?   ?   A . n 
A 1 5   ALA 5   41  ?   ?   ?   A . n 
A 1 6   GLU 6   42  ?   ?   ?   A . n 
A 1 7   GLU 7   43  ?   ?   ?   A . n 
A 1 8   ARG 8   44  ?   ?   ?   A . n 
A 1 9   ASN 9   45  ?   ?   ?   A . n 
A 1 10  LYS 10  46  ?   ?   ?   A . n 
A 1 11  PHE 11  47  47  PHE PHE A . n 
A 1 12  ASP 12  48  48  ASP ASP A . n 
A 1 13  LYS 13  49  49  LYS LYS A . n 
A 1 14  LEU 14  50  50  LEU LEU A . n 
A 1 15  ASP 15  51  51  ASP ASP A . n 
A 1 16  PRO 16  52  52  PRO PRO A . n 
A 1 17  TYR 17  53  53  TYR TYR A . n 
A 1 18  PHE 18  54  54  PHE PHE A . n 
A 1 19  GLN 19  55  55  GLN GLN A . n 
A 1 20  GLN 20  56  56  GLN GLN A . n 
A 1 21  GLY 21  57  57  GLY GLY A . n 
A 1 22  TRP 22  58  58  TRP TRP A . n 
A 1 23  PHE 23  59  59  PHE PHE A . n 
A 1 24  HIS 24  60  60  HIS HIS A . n 
A 1 25  PHE 25  61  61  PHE PHE A . n 
A 1 26  GLN 26  62  62  GLN GLN A . n 
A 1 27  LYS 27  63  63  LYS LYS A . n 
A 1 28  SER 28  64  64  SER SER A . n 
A 1 29  LEU 29  65  65  LEU LEU A . n 
A 1 30  TYR 30  66  66  TYR TYR A . n 
A 1 31  TYR 31  67  67  TYR TYR A . n 
A 1 32  ILE 32  68  68  ILE ILE A . n 
A 1 33  SER 33  69  69  SER SER A . n 
A 1 34  SER 34  70  70  SER SER A . n 
A 1 35  VAL 35  71  71  VAL VAL A . n 
A 1 36  LYS 36  72  72  LYS LYS A . n 
A 1 37  ASN 37  73  73  ASN ASN A . n 
A 1 38  THR 38  74  74  THR THR A . n 
A 1 39  TRP 39  75  75  TRP TRP A . n 
A 1 40  HIS 40  76  76  HIS HIS A . n 
A 1 41  LEU 41  77  77  LEU LEU A . n 
A 1 42  SER 42  78  78  SER SER A . n 
A 1 43  ARG 43  79  79  ARG ARG A . n 
A 1 44  GLU 44  80  80  GLU GLU A . n 
A 1 45  TYR 45  81  81  TYR TYR A . n 
A 1 46  CYS 46  82  82  CYS CYS A . n 
A 1 47  LEU 47  83  83  LEU LEU A . n 
A 1 48  GLN 48  84  84  GLN GLN A . n 
A 1 49  GLU 49  85  85  GLU GLU A . n 
A 1 50  GLY 50  86  86  GLY GLY A . n 
A 1 51  ALA 51  87  87  ALA ALA A . n 
A 1 52  ASP 52  88  88  ASP ASP A . n 
A 1 53  LEU 53  89  89  LEU LEU A . n 
A 1 54  ALA 54  90  90  ALA ALA A . n 
A 1 55  ILE 55  91  91  ILE ILE A . n 
A 1 56  ILE 56  92  92  ILE ILE A . n 
A 1 57  ASN 57  93  93  ASN ASN A . n 
A 1 58  SER 58  94  94  SER SER A . n 
A 1 59  ARG 59  95  95  ARG ARG A . n 
A 1 60  ALA 60  96  96  ALA ALA A . n 
A 1 61  GLU 61  97  97  GLU GLU A . n 
A 1 62  GLN 62  98  98  GLN GLN A . n 
A 1 63  ALA 63  99  99  ALA ALA A . n 
A 1 64  PHE 64  100 100 PHE PHE A . n 
A 1 65  LEU 65  101 101 LEU LEU A . n 
A 1 66  GLU 66  102 102 GLU GLU A . n 
A 1 67  ASN 67  103 103 ASN ASN A . n 
A 1 68  PHE 68  104 104 PHE PHE A . n 
A 1 69  LYS 69  105 105 LYS LYS A . n 
A 1 70  MET 70  106 106 MET MET A . n 
A 1 71  THR 71  107 107 THR THR A . n 
A 1 72  LEU 72  108 108 LEU LEU A . n 
A 1 73  TRP 73  109 109 TRP TRP A . n 
A 1 74  ILE 74  110 110 ILE ILE A . n 
A 1 75  GLY 75  111 111 GLY GLY A . n 
A 1 76  LEU 76  112 112 LEU LEU A . n 
A 1 77  MET 77  113 113 MET MET A . n 
A 1 78  GLU 78  114 114 GLU GLU A . n 
A 1 79  GLN 79  115 115 GLN GLN A . n 
A 1 80  ARG 80  116 116 ARG ARG A . n 
A 1 81  SER 81  117 117 SER SER A . n 
A 1 82  GLU 82  118 118 GLU GLU A . n 
A 1 83  ARG 83  119 119 ARG ARG A . n 
A 1 84  THR 84  120 120 THR THR A . n 
A 1 85  TRP 85  121 121 TRP TRP A . n 
A 1 86  ARG 86  122 122 ARG ARG A . n 
A 1 87  TRP 87  123 123 TRP TRP A . n 
A 1 88  VAL 88  124 124 VAL VAL A . n 
A 1 89  ASP 89  125 125 ASP ASP A . n 
A 1 90  GLY 90  126 126 GLY GLY A . n 
A 1 91  THR 91  127 127 THR THR A . n 
A 1 92  PRO 92  128 128 PRO PRO A . n 
A 1 93  LEU 93  129 129 LEU LEU A . n 
A 1 94  THR 94  130 130 THR THR A . n 
A 1 95  GLU 95  131 131 GLU GLU A . n 
A 1 96  SER 96  132 132 SER SER A . n 
A 1 97  TYR 97  133 133 TYR TYR A . n 
A 1 98  TRP 98  134 134 TRP TRP A . n 
A 1 99  SER 99  135 135 SER SER A . n 
A 1 100 LEU 100 136 136 LEU LEU A . n 
A 1 101 GLY 101 137 137 GLY GLY A . n 
A 1 102 GLU 102 138 138 GLU GLU A . n 
A 1 103 PRO 103 139 139 PRO PRO A . n 
A 1 104 ASN 104 140 140 ASN ASN A . n 
A 1 105 ASN 105 141 141 ASN ASN A . n 
A 1 106 TYR 106 142 142 TYR TYR A . n 
A 1 107 GLU 107 143 143 GLU GLU A . n 
A 1 108 GLY 108 144 144 GLY GLY A . n 
A 1 109 ARG 109 145 145 ARG ARG A . n 
A 1 110 GLN 110 146 146 GLN GLN A . n 
A 1 111 GLU 111 147 147 GLU GLU A . n 
A 1 112 GLN 112 148 148 GLN GLN A . n 
A 1 113 CYS 113 149 149 CYS CYS A . n 
A 1 114 VAL 114 150 150 VAL VAL A . n 
A 1 115 GLU 115 151 151 GLU GLU A . n 
A 1 116 GLN 116 152 152 GLN GLN A . n 
A 1 117 ILE 117 153 153 ILE ILE A . n 
A 1 118 ASP 118 154 154 ASP ASP A . n 
A 1 119 ARG 119 155 155 ARG ARG A . n 
A 1 120 GLU 120 156 156 GLU GLU A . n 
A 1 121 ASP 121 157 157 ASP ASP A . n 
A 1 122 LYS 122 158 158 LYS LYS A . n 
A 1 123 LYS 123 159 159 LYS LYS A . n 
A 1 124 GLY 124 160 160 GLY GLY A . n 
A 1 125 TRP 125 161 161 TRP TRP A . n 
A 1 126 ASN 126 162 162 ASN ASN A . n 
A 1 127 ASP 127 163 163 ASP ASP A . n 
A 1 128 LEU 128 164 164 LEU LEU A . n 
A 1 129 VAL 129 165 165 VAL VAL A . n 
A 1 130 CYS 130 166 166 CYS CYS A . n 
A 1 131 GLU 131 167 167 GLU GLU A . n 
A 1 132 PHE 132 168 168 PHE PHE A . n 
A 1 133 SER 133 169 169 SER SER A . n 
A 1 134 ASN 134 170 170 ASN ASN A . n 
A 1 135 PHE 135 171 171 PHE PHE A . n 
A 1 136 TYR 136 172 172 TYR TYR A . n 
A 1 137 MET 137 173 173 MET MET A . n 
A 1 138 CYS 138 174 174 CYS CYS A . n 
A 1 139 GLU 139 175 175 GLU GLU A . n 
A 1 140 LYS 140 176 176 LYS LYS A . n 
A 1 141 ARG 141 177 177 ARG ARG A . n 
A 1 142 ILE 142 178 178 ILE ILE A . n 
A 1 143 PHE 143 179 179 PHE PHE A . n 
A 1 144 PRO 144 180 180 PRO PRO A . n 
B 1 1   MET 1   37  ?   ?   ?   E . n 
B 1 2   ASN 2   38  ?   ?   ?   E . n 
B 1 3   GLY 3   39  ?   ?   ?   E . n 
B 1 4   THR 4   40  ?   ?   ?   E . n 
B 1 5   ALA 5   41  ?   ?   ?   E . n 
B 1 6   GLU 6   42  ?   ?   ?   E . n 
B 1 7   GLU 7   43  ?   ?   ?   E . n 
B 1 8   ARG 8   44  ?   ?   ?   E . n 
B 1 9   ASN 9   45  ?   ?   ?   E . n 
B 1 10  LYS 10  46  ?   ?   ?   E . n 
B 1 11  PHE 11  47  47  PHE PHE E . n 
B 1 12  ASP 12  48  48  ASP ASP E . n 
B 1 13  LYS 13  49  49  LYS LYS E . n 
B 1 14  LEU 14  50  50  LEU LEU E . n 
B 1 15  ASP 15  51  51  ASP ASP E . n 
B 1 16  PRO 16  52  52  PRO PRO E . n 
B 1 17  TYR 17  53  53  TYR TYR E . n 
B 1 18  PHE 18  54  54  PHE PHE E . n 
B 1 19  GLN 19  55  55  GLN GLN E . n 
B 1 20  GLN 20  56  56  GLN GLN E . n 
B 1 21  GLY 21  57  57  GLY GLY E . n 
B 1 22  TRP 22  58  58  TRP TRP E . n 
B 1 23  PHE 23  59  59  PHE PHE E . n 
B 1 24  HIS 24  60  60  HIS HIS E . n 
B 1 25  PHE 25  61  61  PHE PHE E . n 
B 1 26  GLN 26  62  62  GLN GLN E . n 
B 1 27  LYS 27  63  63  LYS LYS E . n 
B 1 28  SER 28  64  64  SER SER E . n 
B 1 29  LEU 29  65  65  LEU LEU E . n 
B 1 30  TYR 30  66  66  TYR TYR E . n 
B 1 31  TYR 31  67  67  TYR TYR E . n 
B 1 32  ILE 32  68  68  ILE ILE E . n 
B 1 33  SER 33  69  69  SER SER E . n 
B 1 34  SER 34  70  70  SER SER E . n 
B 1 35  VAL 35  71  71  VAL VAL E . n 
B 1 36  LYS 36  72  72  LYS LYS E . n 
B 1 37  ASN 37  73  73  ASN ASN E . n 
B 1 38  THR 38  74  74  THR THR E . n 
B 1 39  TRP 39  75  75  TRP TRP E . n 
B 1 40  HIS 40  76  76  HIS HIS E . n 
B 1 41  LEU 41  77  77  LEU LEU E . n 
B 1 42  SER 42  78  78  SER SER E . n 
B 1 43  ARG 43  79  79  ARG ARG E . n 
B 1 44  GLU 44  80  80  GLU GLU E . n 
B 1 45  TYR 45  81  81  TYR TYR E . n 
B 1 46  CYS 46  82  82  CYS CYS E . n 
B 1 47  LEU 47  83  83  LEU LEU E . n 
B 1 48  GLN 48  84  84  GLN GLN E . n 
B 1 49  GLU 49  85  85  GLU GLU E . n 
B 1 50  GLY 50  86  86  GLY GLY E . n 
B 1 51  ALA 51  87  87  ALA ALA E . n 
B 1 52  ASP 52  88  88  ASP ASP E . n 
B 1 53  LEU 53  89  89  LEU LEU E . n 
B 1 54  ALA 54  90  90  ALA ALA E . n 
B 1 55  ILE 55  91  91  ILE ILE E . n 
B 1 56  ILE 56  92  92  ILE ILE E . n 
B 1 57  ASN 57  93  93  ASN ASN E . n 
B 1 58  SER 58  94  94  SER SER E . n 
B 1 59  ARG 59  95  95  ARG ARG E . n 
B 1 60  ALA 60  96  96  ALA ALA E . n 
B 1 61  GLU 61  97  97  GLU GLU E . n 
B 1 62  GLN 62  98  98  GLN GLN E . n 
B 1 63  ALA 63  99  99  ALA ALA E . n 
B 1 64  PHE 64  100 100 PHE PHE E . n 
B 1 65  LEU 65  101 101 LEU LEU E . n 
B 1 66  GLU 66  102 102 GLU GLU E . n 
B 1 67  ASN 67  103 103 ASN ASN E . n 
B 1 68  PHE 68  104 104 PHE PHE E . n 
B 1 69  LYS 69  105 105 LYS LYS E . n 
B 1 70  MET 70  106 106 MET MET E . n 
B 1 71  THR 71  107 107 THR THR E . n 
B 1 72  LEU 72  108 108 LEU LEU E . n 
B 1 73  TRP 73  109 109 TRP TRP E . n 
B 1 74  ILE 74  110 110 ILE ILE E . n 
B 1 75  GLY 75  111 111 GLY GLY E . n 
B 1 76  LEU 76  112 112 LEU LEU E . n 
B 1 77  MET 77  113 113 MET MET E . n 
B 1 78  GLU 78  114 114 GLU GLU E . n 
B 1 79  GLN 79  115 115 GLN GLN E . n 
B 1 80  ARG 80  116 116 ARG ARG E . n 
B 1 81  SER 81  117 117 SER SER E . n 
B 1 82  GLU 82  118 118 GLU GLU E . n 
B 1 83  ARG 83  119 119 ARG ARG E . n 
B 1 84  THR 84  120 120 THR THR E . n 
B 1 85  TRP 85  121 121 TRP TRP E . n 
B 1 86  ARG 86  122 122 ARG ARG E . n 
B 1 87  TRP 87  123 123 TRP TRP E . n 
B 1 88  VAL 88  124 124 VAL VAL E . n 
B 1 89  ASP 89  125 125 ASP ASP E . n 
B 1 90  GLY 90  126 126 GLY GLY E . n 
B 1 91  THR 91  127 127 THR THR E . n 
B 1 92  PRO 92  128 128 PRO PRO E . n 
B 1 93  LEU 93  129 129 LEU LEU E . n 
B 1 94  THR 94  130 130 THR THR E . n 
B 1 95  GLU 95  131 131 GLU GLU E . n 
B 1 96  SER 96  132 132 SER SER E . n 
B 1 97  TYR 97  133 133 TYR TYR E . n 
B 1 98  TRP 98  134 134 TRP TRP E . n 
B 1 99  SER 99  135 135 SER SER E . n 
B 1 100 LEU 100 136 136 LEU LEU E . n 
B 1 101 GLY 101 137 137 GLY GLY E . n 
B 1 102 GLU 102 138 138 GLU GLU E . n 
B 1 103 PRO 103 139 139 PRO PRO E . n 
B 1 104 ASN 104 140 140 ASN ASN E . n 
B 1 105 ASN 105 141 141 ASN ASN E . n 
B 1 106 TYR 106 142 142 TYR TYR E . n 
B 1 107 GLU 107 143 143 GLU GLU E . n 
B 1 108 GLY 108 144 144 GLY GLY E . n 
B 1 109 ARG 109 145 145 ARG ARG E . n 
B 1 110 GLN 110 146 146 GLN GLN E . n 
B 1 111 GLU 111 147 147 GLU GLU E . n 
B 1 112 GLN 112 148 148 GLN GLN E . n 
B 1 113 CYS 113 149 149 CYS CYS E . n 
B 1 114 VAL 114 150 150 VAL VAL E . n 
B 1 115 GLU 115 151 151 GLU GLU E . n 
B 1 116 GLN 116 152 152 GLN GLN E . n 
B 1 117 ILE 117 153 153 ILE ILE E . n 
B 1 118 ASP 118 154 154 ASP ASP E . n 
B 1 119 ARG 119 155 155 ARG ARG E . n 
B 1 120 GLU 120 156 156 GLU GLU E . n 
B 1 121 ASP 121 157 157 ASP ASP E . n 
B 1 122 LYS 122 158 158 LYS LYS E . n 
B 1 123 LYS 123 159 159 LYS LYS E . n 
B 1 124 GLY 124 160 160 GLY GLY E . n 
B 1 125 TRP 125 161 161 TRP TRP E . n 
B 1 126 ASN 126 162 162 ASN ASN E . n 
B 1 127 ASP 127 163 163 ASP ASP E . n 
B 1 128 LEU 128 164 164 LEU LEU E . n 
B 1 129 VAL 129 165 165 VAL VAL E . n 
B 1 130 CYS 130 166 166 CYS CYS E . n 
B 1 131 GLU 131 167 167 GLU GLU E . n 
B 1 132 PHE 132 168 168 PHE PHE E . n 
B 1 133 SER 133 169 169 SER SER E . n 
B 1 134 ASN 134 170 170 ASN ASN E . n 
B 1 135 PHE 135 171 171 PHE PHE E . n 
B 1 136 TYR 136 172 172 TYR TYR E . n 
B 1 137 MET 137 173 173 MET MET E . n 
B 1 138 CYS 138 174 174 CYS CYS E . n 
B 1 139 GLU 139 175 175 GLU GLU E . n 
B 1 140 LYS 140 176 176 LYS LYS E . n 
B 1 141 ARG 141 177 177 ARG ARG E . n 
B 1 142 ILE 142 178 178 ILE ILE E . n 
B 1 143 PHE 143 179 179 PHE PHE E . n 
B 1 144 PRO 144 180 180 PRO PRO E . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 GLC ? ? GLC ? ? 'SUBJECT OF INVESTIGATION' ? 
2 BGC ? ? BGC ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 GLC 1  201 238 GLC XXX A . 
D 3 BGC 1  202 239 BGC YYY A . 
E 4 CA  1  203 1   CA  CA  A . 
F 4 CA  1  204 3   CA  CA  A . 
G 2 GLC 1  201 238 GLC XXX E . 
H 3 BGC 1  202 239 BGC YYY E . 
I 4 CA  1  203 1   CA  CA  E . 
J 4 CA  1  204 3   CA  CA  E . 
K 5 HOH 1  301 3   HOH HOH A . 
K 5 HOH 2  302 126 HOH HOH A . 
K 5 HOH 3  303 166 HOH HOH A . 
K 5 HOH 4  304 124 HOH HOH A . 
K 5 HOH 5  305 13  HOH HOH A . 
K 5 HOH 6  306 14  HOH HOH A . 
K 5 HOH 7  307 15  HOH HOH A . 
K 5 HOH 8  308 18  HOH HOH A . 
K 5 HOH 9  309 57  HOH HOH A . 
K 5 HOH 10 310 64  HOH HOH A . 
K 5 HOH 11 311 160 HOH HOH A . 
K 5 HOH 12 312 167 HOH HOH A . 
K 5 HOH 13 313 25  HOH HOH A . 
K 5 HOH 14 314 119 HOH HOH A . 
K 5 HOH 15 315 58  HOH HOH A . 
K 5 HOH 16 316 149 HOH HOH A . 
K 5 HOH 17 317 4   HOH HOH A . 
K 5 HOH 18 318 6   HOH HOH A . 
K 5 HOH 19 319 35  HOH HOH A . 
K 5 HOH 20 320 69  HOH HOH A . 
K 5 HOH 21 321 68  HOH HOH A . 
K 5 HOH 22 322 114 HOH HOH A . 
K 5 HOH 23 323 162 HOH HOH A . 
K 5 HOH 24 324 8   HOH HOH A . 
K 5 HOH 25 325 30  HOH HOH A . 
K 5 HOH 26 326 168 HOH HOH A . 
K 5 HOH 27 327 109 HOH HOH A . 
K 5 HOH 28 328 132 HOH HOH A . 
K 5 HOH 29 329 47  HOH HOH A . 
K 5 HOH 30 330 85  HOH HOH A . 
K 5 HOH 31 331 67  HOH HOH A . 
K 5 HOH 32 332 89  HOH HOH A . 
K 5 HOH 33 333 8   HOH HOH A . 
K 5 HOH 34 334 80  HOH HOH A . 
K 5 HOH 35 335 131 HOH HOH A . 
K 5 HOH 36 336 127 HOH HOH A . 
K 5 HOH 37 337 29  HOH HOH A . 
K 5 HOH 38 338 112 HOH HOH A . 
K 5 HOH 39 339 23  HOH HOH A . 
K 5 HOH 40 340 138 HOH HOH A . 
K 5 HOH 41 341 51  HOH HOH A . 
K 5 HOH 42 342 28  HOH HOH A . 
K 5 HOH 43 343 111 HOH HOH A . 
K 5 HOH 44 344 113 HOH HOH A . 
K 5 HOH 45 345 84  HOH HOH A . 
K 5 HOH 46 346 146 HOH HOH A . 
K 5 HOH 47 347 7   HOH HOH A . 
K 5 HOH 48 348 93  HOH HOH A . 
K 5 HOH 49 349 75  HOH HOH A . 
K 5 HOH 50 350 77  HOH HOH A . 
K 5 HOH 51 351 10  HOH HOH A . 
K 5 HOH 52 352 40  HOH HOH A . 
K 5 HOH 53 353 52  HOH HOH A . 
K 5 HOH 54 354 74  HOH HOH A . 
K 5 HOH 55 355 60  HOH HOH A . 
K 5 HOH 56 356 82  HOH HOH A . 
K 5 HOH 57 357 104 HOH HOH A . 
K 5 HOH 58 358 62  HOH HOH A . 
K 5 HOH 59 359 27  HOH HOH A . 
K 5 HOH 60 360 48  HOH HOH A . 
K 5 HOH 61 361 39  HOH HOH A . 
K 5 HOH 62 362 36  HOH HOH A . 
K 5 HOH 63 363 152 HOH HOH A . 
K 5 HOH 64 364 86  HOH HOH A . 
K 5 HOH 65 365 106 HOH HOH A . 
K 5 HOH 66 366 91  HOH HOH A . 
K 5 HOH 67 367 66  HOH HOH A . 
K 5 HOH 68 368 20  HOH HOH A . 
K 5 HOH 69 369 2   HOH HOH A . 
K 5 HOH 70 370 44  HOH HOH A . 
K 5 HOH 71 371 45  HOH HOH A . 
K 5 HOH 72 372 88  HOH HOH A . 
K 5 HOH 73 373 21  HOH HOH A . 
K 5 HOH 74 374 170 HOH HOH A . 
K 5 HOH 75 375 148 HOH HOH A . 
K 5 HOH 76 376 11  HOH HOH A . 
K 5 HOH 77 377 9   HOH HOH A . 
K 5 HOH 78 378 137 HOH HOH A . 
K 5 HOH 79 379 79  HOH HOH A . 
K 5 HOH 80 380 98  HOH HOH A . 
K 5 HOH 81 381 130 HOH HOH A . 
K 5 HOH 82 382 165 HOH HOH A . 
K 5 HOH 83 383 125 HOH HOH A . 
K 5 HOH 84 384 139 HOH HOH A . 
K 5 HOH 85 385 92  HOH HOH A . 
K 5 HOH 86 386 19  HOH HOH A . 
K 5 HOH 87 387 134 HOH HOH A . 
K 5 HOH 88 388 90  HOH HOH A . 
K 5 HOH 89 389 147 HOH HOH A . 
K 5 HOH 90 390 26  HOH HOH A . 
K 5 HOH 91 391 120 HOH HOH A . 
K 5 HOH 92 392 161 HOH HOH A . 
K 5 HOH 93 393 70  HOH HOH A . 
K 5 HOH 94 394 151 HOH HOH A . 
K 5 HOH 95 395 159 HOH HOH A . 
K 5 HOH 96 396 115 HOH HOH A . 
K 5 HOH 97 397 96  HOH HOH A . 
K 5 HOH 98 398 129 HOH HOH A . 
L 5 HOH 1  301 108 HOH HOH E . 
L 5 HOH 2  302 1   HOH HOH E . 
L 5 HOH 3  303 169 HOH HOH E . 
L 5 HOH 4  304 123 HOH HOH E . 
L 5 HOH 5  305 24  HOH HOH E . 
L 5 HOH 6  306 59  HOH HOH E . 
L 5 HOH 7  307 41  HOH HOH E . 
L 5 HOH 8  308 12  HOH HOH E . 
L 5 HOH 9  309 31  HOH HOH E . 
L 5 HOH 10 310 100 HOH HOH E . 
L 5 HOH 11 311 2   HOH HOH E . 
L 5 HOH 12 312 143 HOH HOH E . 
L 5 HOH 13 313 6   HOH HOH E . 
L 5 HOH 14 314 56  HOH HOH E . 
L 5 HOH 15 315 53  HOH HOH E . 
L 5 HOH 16 316 3   HOH HOH E . 
L 5 HOH 17 317 76  HOH HOH E . 
L 5 HOH 18 318 163 HOH HOH E . 
L 5 HOH 19 319 83  HOH HOH E . 
L 5 HOH 20 320 117 HOH HOH E . 
L 5 HOH 21 321 87  HOH HOH E . 
L 5 HOH 22 322 95  HOH HOH E . 
L 5 HOH 23 323 97  HOH HOH E . 
L 5 HOH 24 324 65  HOH HOH E . 
L 5 HOH 25 325 99  HOH HOH E . 
L 5 HOH 26 326 140 HOH HOH E . 
L 5 HOH 27 327 38  HOH HOH E . 
L 5 HOH 28 328 37  HOH HOH E . 
L 5 HOH 29 329 164 HOH HOH E . 
L 5 HOH 30 330 7   HOH HOH E . 
L 5 HOH 31 331 78  HOH HOH E . 
L 5 HOH 32 332 118 HOH HOH E . 
L 5 HOH 33 333 1   HOH HOH E . 
L 5 HOH 34 334 61  HOH HOH E . 
L 5 HOH 35 335 11  HOH HOH E . 
L 5 HOH 36 336 153 HOH HOH E . 
L 5 HOH 37 337 34  HOH HOH E . 
L 5 HOH 38 338 63  HOH HOH E . 
L 5 HOH 39 339 105 HOH HOH E . 
L 5 HOH 40 340 55  HOH HOH E . 
L 5 HOH 41 341 73  HOH HOH E . 
L 5 HOH 42 342 121 HOH HOH E . 
L 5 HOH 43 343 156 HOH HOH E . 
L 5 HOH 44 344 17  HOH HOH E . 
L 5 HOH 45 345 128 HOH HOH E . 
L 5 HOH 46 346 22  HOH HOH E . 
L 5 HOH 47 347 16  HOH HOH E . 
L 5 HOH 48 348 150 HOH HOH E . 
L 5 HOH 49 349 110 HOH HOH E . 
L 5 HOH 50 350 122 HOH HOH E . 
L 5 HOH 51 351 158 HOH HOH E . 
L 5 HOH 52 352 144 HOH HOH E . 
L 5 HOH 53 353 71  HOH HOH E . 
L 5 HOH 54 354 5   HOH HOH E . 
L 5 HOH 55 355 72  HOH HOH E . 
L 5 HOH 56 356 32  HOH HOH E . 
L 5 HOH 57 357 43  HOH HOH E . 
L 5 HOH 58 358 101 HOH HOH E . 
L 5 HOH 59 359 4   HOH HOH E . 
L 5 HOH 60 360 102 HOH HOH E . 
L 5 HOH 61 361 54  HOH HOH E . 
L 5 HOH 62 362 154 HOH HOH E . 
L 5 HOH 63 363 10  HOH HOH E . 
L 5 HOH 64 364 157 HOH HOH E . 
L 5 HOH 65 365 142 HOH HOH E . 
L 5 HOH 66 366 145 HOH HOH E . 
L 5 HOH 67 367 50  HOH HOH E . 
L 5 HOH 68 368 107 HOH HOH E . 
L 5 HOH 69 369 5   HOH HOH E . 
L 5 HOH 70 370 49  HOH HOH E . 
L 5 HOH 71 371 116 HOH HOH E . 
L 5 HOH 72 372 81  HOH HOH E . 
L 5 HOH 73 373 141 HOH HOH E . 
L 5 HOH 74 374 94  HOH HOH E . 
L 5 HOH 75 375 33  HOH HOH E . 
L 5 HOH 76 376 136 HOH HOH E . 
L 5 HOH 77 377 135 HOH HOH E . 
L 5 HOH 78 378 133 HOH HOH E . 
L 5 HOH 79 379 155 HOH HOH E . 
L 5 HOH 80 380 42  HOH HOH E . 
L 5 HOH 81 381 46  HOH HOH E . 
L 5 HOH 82 382 9   HOH HOH E . 
L 5 HOH 83 383 103 HOH HOH E . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.21_5207 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .         2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .         3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? MOLREP  ? ? ? .         4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   115.774 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9KPL 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     48.353 
_cell.length_a_esd                 ? 
_cell.length_b                     69.860 
_cell.length_b_esd                 ? 
_cell.length_c                     51.584 
_cell.length_c_esd                 ? 
_cell.volume                       156912.861 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9KPL 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            'P 2yb' 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9KPL 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.27 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          45.81 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              8.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1M tris (pH8.5), 0.2M sodium chloride, 25% (w/v) polyethylene glycol (PEG) 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     95 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 4M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-02-18 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.0200 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PHOTON FACTORY BEAMLINE BL-1A' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.0200 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL-1A 
_diffrn_source.pdbx_synchrotron_site       'Photon Factory' 
# 
_reflns.B_iso_Wilson_estimate                          18.07 
_reflns.entry_id                                       9KPL 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.80 
_reflns.d_resolution_low                               46.45 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     28652 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.7 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.5 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          8.6 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                0.041 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.066 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.8 
_reflns_shell.d_res_low                                     1.84 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1716 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               3.6 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               0.226 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.874 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          100 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.369 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               22.91 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9KPL 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.80 
_refine.ls_d_res_low                             46.45 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     28627 
_refine.ls_number_reflns_R_free                  1386 
_refine.ls_number_reflns_R_work                  27241 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.65 
_refine.ls_percent_reflns_R_free                 4.84 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1816 
_refine.ls_R_factor_R_free                       0.2155 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1799 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.93 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 20.3472 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1842 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.80 
_refine_hist.d_res_low                        46.45 
_refine_hist.number_atoms_solvent             181 
_refine_hist.number_atoms_total               2529 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2296 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         52 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0190 ? 2451 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.5329 ? 3325 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.1137 ? 334  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0115 ? 421  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 7.5116 ? 330  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.80 1.86  . . 151 2714 99.97 . . . . 0.2054 . . . . . . . . . . . 0.2523 
'X-RAY DIFFRACTION' 1.86 1.94  . . 140 2708 99.55 . . . . 0.1987 . . . . . . . . . . . 0.2351 
'X-RAY DIFFRACTION' 1.94 2.03  . . 116 2715 99.75 . . . . 0.1813 . . . . . . . . . . . 0.2543 
'X-RAY DIFFRACTION' 2.03 2.13  . . 115 2733 99.48 . . . . 0.1863 . . . . . . . . . . . 0.2215 
'X-RAY DIFFRACTION' 2.13 2.27  . . 146 2708 99.76 . . . . 0.1817 . . . . . . . . . . . 0.2442 
'X-RAY DIFFRACTION' 2.27 2.44  . . 158 2719 99.83 . . . . 0.1903 . . . . . . . . . . . 0.2341 
'X-RAY DIFFRACTION' 2.44 2.69  . . 129 2730 99.76 . . . . 0.1890 . . . . . . . . . . . 0.2517 
'X-RAY DIFFRACTION' 2.69 3.08  . . 140 2702 99.68 . . . . 0.1941 . . . . . . . . . . . 0.2154 
'X-RAY DIFFRACTION' 3.08 3.88  . . 142 2746 99.72 . . . . 0.1722 . . . . . . . . . . . 0.1944 
'X-RAY DIFFRACTION' 3.88 46.45 . . 149 2766 99.12 . . . . 0.1581 . . . . . . . . . . . 0.1833 
# 
_struct.entry_id                     9KPL 
_struct.title                        'Crystal structure of T. rubripes Mincle with glucose' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9KPL 
_struct_keywords.text            'C-type lectin, ectodomain, Carbohydrate recognition doamin, IMMUNE SYSTEM' 
_struct_keywords.pdbx_keywords   'IMMUNE SYSTEM' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 2 ? 
H N N 3 ? 
I N N 4 ? 
J N N 4 ? 
K N N 5 ? 
L N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A3B5KEF3_TAKRU 
_struct_ref.pdbx_db_accession          A0A3B5KEF3 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;NGTAEERNTFDKLDPYFKRGWFHFQKSLYYISSVKNTWHLSREYCLQEGADLAIINSRAEQAFLENFKMTLWIGLMEQRS
ERTWRWVDGTPLTESYWSLGEPNNYEGRQEQCVEQVDREDKKGWNDLVCEFSNFYMCEKRIFP
;
_struct_ref.pdbx_align_begin           52 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9KPL A 2 ? 144 ? A0A3B5KEF3 52 ? 194 ? 38 180 
2 1 9KPL E 2 ? 144 ? A0A3B5KEF3 52 ? 194 ? 38 180 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9KPL MET A 1   ? UNP A0A3B5KEF3 ?   ?   'initiating methionine' 37  1  
1 9KPL LYS A 10  ? UNP A0A3B5KEF3 THR 60  conflict                46  2  
1 9KPL GLN A 19  ? UNP A0A3B5KEF3 LYS 69  conflict                55  3  
1 9KPL GLN A 20  ? UNP A0A3B5KEF3 ARG 70  conflict                56  4  
1 9KPL ILE A 117 ? UNP A0A3B5KEF3 VAL 167 conflict                153 5  
2 9KPL MET E 1   ? UNP A0A3B5KEF3 ?   ?   'initiating methionine' 37  6  
2 9KPL LYS E 10  ? UNP A0A3B5KEF3 THR 60  conflict                46  7  
2 9KPL GLN E 19  ? UNP A0A3B5KEF3 LYS 69  conflict                55  8  
2 9KPL GLN E 20  ? UNP A0A3B5KEF3 ARG 70  conflict                56  9  
2 9KPL ILE E 117 ? UNP A0A3B5KEF3 VAL 167 conflict                153 10 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 3850  ? 
1 MORE         -50   ? 
1 'SSA (A^2)'  12930 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 LEU A 14  ? GLN A 20  ? LEU A 50  GLN A 56  1 ? 7  
HELX_P HELX_P2 AA2 THR A 38  ? GLU A 49  ? THR A 74  GLU A 85  1 ? 12 
HELX_P HELX_P3 AA3 SER A 58  ? ASN A 67  ? SER A 94  ASN A 103 1 ? 10 
HELX_P HELX_P4 AA4 ASN A 105 ? ARG A 109 ? ASN A 141 ARG A 145 5 ? 5  
HELX_P HELX_P5 AA5 PHE B 11  ? LYS B 13  ? PHE E 47  LYS E 49  5 ? 3  
HELX_P HELX_P6 AA6 LEU B 14  ? GLN B 20  ? LEU E 50  GLN E 56  1 ? 7  
HELX_P HELX_P7 AA7 THR B 38  ? GLU B 49  ? THR E 74  GLU E 85  1 ? 12 
HELX_P HELX_P8 AA8 SER B 58  ? ASN B 67  ? SER E 94  ASN E 103 1 ? 10 
HELX_P HELX_P9 AA9 ASN B 105 ? ARG B 109 ? ASN E 141 ARG E 145 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1  disulf ? ? A CYS 46  SG  ? ? ? 1_555 A CYS 138 SG ? ? A CYS 82  A CYS 174 1_555 ? ? ? ? ? ? ? 2.099 ? ? 
disulf2  disulf ? ? A CYS 113 SG  ? ? ? 1_555 A CYS 130 SG ? ? A CYS 149 A CYS 166 1_555 ? ? ? ? ? ? ? 2.113 ? ? 
disulf3  disulf ? ? B CYS 46  SG  ? ? ? 1_555 B CYS 138 SG ? ? E CYS 82  E CYS 174 1_555 ? ? ? ? ? ? ? 2.095 ? ? 
disulf4  disulf ? ? B CYS 113 SG  ? ? ? 1_555 B CYS 130 SG ? ? E CYS 149 E CYS 166 1_555 ? ? ? ? ? ? ? 2.114 ? ? 
metalc1  metalc ? ? A ILE 55  O   ? ? ? 1_555 E CA  .   CA ? ? A ILE 91  A CA  203 1_555 ? ? ? ? ? ? ? 2.340 ? ? 
metalc2  metalc ? ? A ASN 57  OD1 ? ? ? 1_555 E CA  .   CA ? ? A ASN 93  A CA  203 1_555 ? ? ? ? ? ? ? 2.364 ? ? 
metalc3  metalc ? ? A GLU 61  OE1 ? ? ? 1_555 E CA  .   CA ? ? A GLU 97  A CA  203 1_555 ? ? ? ? ? ? ? 2.603 ? ? 
metalc4  metalc ? ? A GLU 61  OE2 ? ? ? 1_555 E CA  .   CA ? ? A GLU 97  A CA  203 1_555 ? ? ? ? ? ? ? 2.459 ? ? 
metalc5  metalc ? ? A GLU 102 OE1 ? ? ? 1_555 F CA  .   CA ? ? A GLU 138 A CA  204 1_555 ? ? ? ? ? ? ? 2.572 ? ? 
metalc6  metalc ? ? A ASN 104 OD1 ? ? ? 1_555 F CA  .   CA ? ? A ASN 140 A CA  204 1_555 ? ? ? ? ? ? ? 2.447 ? ? 
metalc7  metalc ? ? A GLU 111 OE1 ? ? ? 1_555 F CA  .   CA ? ? A GLU 147 A CA  204 1_555 ? ? ? ? ? ? ? 2.429 ? ? 
metalc8  metalc ? ? A ASN 126 OD1 ? ? ? 1_555 F CA  .   CA ? ? A ASN 162 A CA  204 1_555 ? ? ? ? ? ? ? 2.361 ? ? 
metalc9  metalc ? ? A ASP 127 O   ? ? ? 1_555 F CA  .   CA ? ? A ASP 163 A CA  204 1_555 ? ? ? ? ? ? ? 2.481 ? ? 
metalc10 metalc ? ? A ASP 127 OD1 ? ? ? 1_555 F CA  .   CA ? ? A ASP 163 A CA  204 1_555 ? ? ? ? ? ? ? 2.412 ? ? 
metalc11 metalc ? ? A GLU 139 OE1 ? ? ? 1_555 E CA  .   CA ? ? A GLU 175 A CA  203 1_555 ? ? ? ? ? ? ? 2.561 ? ? 
metalc12 metalc ? ? A GLU 139 OE2 ? ? ? 1_555 E CA  .   CA ? ? A GLU 175 A CA  203 1_555 ? ? ? ? ? ? ? 2.445 ? ? 
metalc13 metalc ? ? C GLC .   O3  A ? ? 1_555 F CA  .   CA ? ? A GLC 201 A CA  204 1_555 ? ? ? ? ? ? ? 2.540 ? ? 
metalc14 metalc ? ? C GLC .   O4  A ? ? 1_555 F CA  .   CA ? ? A GLC 201 A CA  204 1_555 ? ? ? ? ? ? ? 2.555 ? ? 
metalc15 metalc ? ? D BGC .   O3  B ? ? 1_555 F CA  .   CA ? ? A BGC 202 A CA  204 1_555 ? ? ? ? ? ? ? 2.567 ? ? 
metalc16 metalc ? ? D BGC .   O4  B ? ? 1_555 F CA  .   CA ? ? A BGC 202 A CA  204 1_555 ? ? ? ? ? ? ? 2.625 ? ? 
metalc17 metalc ? ? E CA  .   CA  ? ? ? 1_555 K HOH .   O  ? ? A CA  203 A HOH 351 1_555 ? ? ? ? ? ? ? 2.469 ? ? 
metalc18 metalc ? ? E CA  .   CA  ? ? ? 1_555 K HOH .   O  ? ? A CA  203 A HOH 377 1_555 ? ? ? ? ? ? ? 2.511 ? ? 
metalc19 metalc ? ? B ILE 55  O   ? ? ? 1_555 I CA  .   CA ? ? E ILE 91  E CA  203 1_555 ? ? ? ? ? ? ? 2.306 ? ? 
metalc20 metalc ? ? B ASN 57  OD1 ? ? ? 1_555 I CA  .   CA ? ? E ASN 93  E CA  203 1_555 ? ? ? ? ? ? ? 2.294 ? ? 
metalc21 metalc ? ? B GLU 61  OE1 ? ? ? 1_555 I CA  .   CA ? ? E GLU 97  E CA  203 1_555 ? ? ? ? ? ? ? 2.714 ? ? 
metalc22 metalc ? ? B GLU 61  OE2 ? ? ? 1_555 I CA  .   CA ? ? E GLU 97  E CA  203 1_555 ? ? ? ? ? ? ? 2.488 ? ? 
metalc23 metalc ? ? B GLU 102 OE1 ? ? ? 1_555 J CA  .   CA ? ? E GLU 138 E CA  204 1_555 ? ? ? ? ? ? ? 2.525 ? ? 
metalc24 metalc ? ? B ASN 104 OD1 ? ? ? 1_555 J CA  .   CA ? ? E ASN 140 E CA  204 1_555 ? ? ? ? ? ? ? 2.438 ? ? 
metalc25 metalc ? ? B GLU 111 OE1 ? ? ? 1_555 J CA  .   CA ? ? E GLU 147 E CA  204 1_555 ? ? ? ? ? ? ? 2.451 ? ? 
metalc26 metalc ? ? B ASN 126 OD1 ? ? ? 1_555 J CA  .   CA ? ? E ASN 162 E CA  204 1_555 ? ? ? ? ? ? ? 2.357 ? ? 
metalc27 metalc ? ? B ASP 127 O   ? ? ? 1_555 J CA  .   CA ? ? E ASP 163 E CA  204 1_555 ? ? ? ? ? ? ? 2.465 ? ? 
metalc28 metalc ? ? B ASP 127 OD1 ? ? ? 1_555 J CA  .   CA ? ? E ASP 163 E CA  204 1_555 ? ? ? ? ? ? ? 2.420 ? ? 
metalc29 metalc ? ? B GLU 139 OE1 ? ? ? 1_555 I CA  .   CA ? ? E GLU 175 E CA  203 1_555 ? ? ? ? ? ? ? 2.562 ? ? 
metalc30 metalc ? ? B GLU 139 OE2 ? ? ? 1_555 I CA  .   CA ? ? E GLU 175 E CA  203 1_555 ? ? ? ? ? ? ? 2.545 ? ? 
metalc31 metalc ? ? G GLC .   O3  A ? ? 1_555 J CA  .   CA ? ? E GLC 201 E CA  204 1_555 ? ? ? ? ? ? ? 2.498 ? ? 
metalc32 metalc ? ? G GLC .   O4  A ? ? 1_555 J CA  .   CA ? ? E GLC 201 E CA  204 1_555 ? ? ? ? ? ? ? 2.549 ? ? 
metalc33 metalc ? ? H BGC .   O3  B ? ? 1_555 J CA  .   CA ? ? E BGC 202 E CA  204 1_555 ? ? ? ? ? ? ? 2.535 ? ? 
metalc34 metalc ? ? H BGC .   O4  B ? ? 1_555 J CA  .   CA ? ? E BGC 202 E CA  204 1_555 ? ? ? ? ? ? ? 2.588 ? ? 
metalc35 metalc ? ? I CA  .   CA  ? ? ? 1_555 L HOH .   O  ? ? E CA  203 E HOH 346 1_555 ? ? ? ? ? ? ? 2.449 ? ? 
metalc36 metalc ? ? I CA  .   CA  ? ? ? 1_555 L HOH .   O  ? ? E CA  203 E HOH 352 1_555 ? ? ? ? ? ? ? 2.472 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1   O   ? A ILE 55  ? A ILE 91  ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 OD1 ? A ASN 57  ? A ASN 93  ? 1_555 77.1  ? 
2   O   ? A ILE 55  ? A ILE 91  ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 OE1 ? A GLU 61  ? A GLU 97  ? 1_555 76.4  ? 
3   OD1 ? A ASN 57  ? A ASN 93  ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 OE1 ? A GLU 61  ? A GLU 97  ? 1_555 79.0  ? 
4   O   ? A ILE 55  ? A ILE 91  ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 OE2 ? A GLU 61  ? A GLU 97  ? 1_555 83.8  ? 
5   OD1 ? A ASN 57  ? A ASN 93  ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 OE2 ? A GLU 61  ? A GLU 97  ? 1_555 130.9 ? 
6   OE1 ? A GLU 61  ? A GLU 97  ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 OE2 ? A GLU 61  ? A GLU 97  ? 1_555 52.5  ? 
7   O   ? A ILE 55  ? A ILE 91  ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 OE1 ? A GLU 139 ? A GLU 175 ? 1_555 78.7  ? 
8   OD1 ? A ASN 57  ? A ASN 93  ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 OE1 ? A GLU 139 ? A GLU 175 ? 1_555 136.4 ? 
9   OE1 ? A GLU 61  ? A GLU 97  ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 OE1 ? A GLU 139 ? A GLU 175 ? 1_555 128.9 ? 
10  OE2 ? A GLU 61  ? A GLU 97  ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 OE1 ? A GLU 139 ? A GLU 175 ? 1_555 81.1  ? 
11  O   ? A ILE 55  ? A ILE 91  ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 OE2 ? A GLU 139 ? A GLU 175 ? 1_555 128.6 ? 
12  OD1 ? A ASN 57  ? A ASN 93  ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 OE2 ? A GLU 139 ? A GLU 175 ? 1_555 144.7 ? 
13  OE1 ? A GLU 61  ? A GLU 97  ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 OE2 ? A GLU 139 ? A GLU 175 ? 1_555 126.2 ? 
14  OE2 ? A GLU 61  ? A GLU 97  ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 OE2 ? A GLU 139 ? A GLU 175 ? 1_555 80.7  ? 
15  OE1 ? A GLU 139 ? A GLU 175 ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 OE2 ? A GLU 139 ? A GLU 175 ? 1_555 50.6  ? 
16  O   ? A ILE 55  ? A ILE 91  ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 O   ? K HOH .   ? A HOH 351 ? 1_555 102.0 ? 
17  OD1 ? A ASN 57  ? A ASN 93  ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 O   ? K HOH .   ? A HOH 351 ? 1_555 72.2  ? 
18  OE1 ? A GLU 61  ? A GLU 97  ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 O   ? K HOH .   ? A HOH 351 ? 1_555 150.7 ? 
19  OE2 ? A GLU 61  ? A GLU 97  ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 O   ? K HOH .   ? A HOH 351 ? 1_555 156.8 ? 
20  OE1 ? A GLU 139 ? A GLU 175 ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 O   ? K HOH .   ? A HOH 351 ? 1_555 78.1  ? 
21  OE2 ? A GLU 139 ? A GLU 175 ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 O   ? K HOH .   ? A HOH 351 ? 1_555 78.2  ? 
22  O   ? A ILE 55  ? A ILE 91  ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 O   ? K HOH .   ? A HOH 377 ? 1_555 149.0 ? 
23  OD1 ? A ASN 57  ? A ASN 93  ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 O   ? K HOH .   ? A HOH 377 ? 1_555 83.0  ? 
24  OE1 ? A GLU 61  ? A GLU 97  ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 O   ? K HOH .   ? A HOH 377 ? 1_555 76.7  ? 
25  OE2 ? A GLU 61  ? A GLU 97  ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 O   ? K HOH .   ? A HOH 377 ? 1_555 91.7  ? 
26  OE1 ? A GLU 139 ? A GLU 175 ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 O   ? K HOH .   ? A HOH 377 ? 1_555 130.9 ? 
27  OE2 ? A GLU 139 ? A GLU 175 ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 O   ? K HOH .   ? A HOH 377 ? 1_555 80.3  ? 
28  O   ? K HOH .   ? A HOH 351 ? 1_555 CA ? E CA . ? A CA 203 ? 1_555 O   ? K HOH .   ? A HOH 377 ? 1_555 94.1  ? 
29  OE1 ? A GLU 102 ? A GLU 138 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 OD1 ? A ASN 104 ? A ASN 140 ? 1_555 71.9  ? 
30  OE1 ? A GLU 102 ? A GLU 138 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 OE1 ? A GLU 111 ? A GLU 147 ? 1_555 143.9 ? 
31  OD1 ? A ASN 104 ? A ASN 140 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 OE1 ? A GLU 111 ? A GLU 147 ? 1_555 75.8  ? 
32  OE1 ? A GLU 102 ? A GLU 138 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 OD1 ? A ASN 126 ? A ASN 162 ? 1_555 68.5  ? 
33  OD1 ? A ASN 104 ? A ASN 140 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 OD1 ? A ASN 126 ? A ASN 162 ? 1_555 137.7 ? 
34  OE1 ? A GLU 111 ? A GLU 147 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 OD1 ? A ASN 126 ? A ASN 162 ? 1_555 146.2 ? 
35  OE1 ? A GLU 102 ? A GLU 138 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O   ? A ASP 127 ? A ASP 163 ? 1_555 128.5 ? 
36  OD1 ? A ASN 104 ? A ASN 140 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O   ? A ASP 127 ? A ASP 163 ? 1_555 143.3 ? 
37  OE1 ? A GLU 111 ? A GLU 147 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O   ? A ASP 127 ? A ASP 163 ? 1_555 73.0  ? 
38  OD1 ? A ASN 126 ? A ASN 162 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O   ? A ASP 127 ? A ASP 163 ? 1_555 76.2  ? 
39  OE1 ? A GLU 102 ? A GLU 138 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 OD1 ? A ASP 127 ? A ASP 163 ? 1_555 72.8  ? 
40  OD1 ? A ASN 104 ? A ASN 140 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 OD1 ? A ASP 127 ? A ASP 163 ? 1_555 84.4  ? 
41  OE1 ? A GLU 111 ? A GLU 147 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 OD1 ? A ASP 127 ? A ASP 163 ? 1_555 88.5  ? 
42  OD1 ? A ASN 126 ? A ASN 162 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 OD1 ? A ASP 127 ? A ASP 163 ? 1_555 97.4  ? 
43  O   ? A ASP 127 ? A ASP 163 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 OD1 ? A ASP 127 ? A ASP 163 ? 1_555 76.0  ? 
44  OE1 ? A GLU 102 ? A GLU 138 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O3  A C GLC .   ? A GLC 201 ? 1_555 74.2  ? 
45  OD1 ? A ASN 104 ? A ASN 140 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O3  A C GLC .   ? A GLC 201 ? 1_555 76.3  ? 
46  OE1 ? A GLU 111 ? A GLU 147 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O3  A C GLC .   ? A GLC 201 ? 1_555 113.3 ? 
47  OD1 ? A ASN 126 ? A ASN 162 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O3  A C GLC .   ? A GLC 201 ? 1_555 79.2  ? 
48  O   ? A ASP 127 ? A ASP 163 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O3  A C GLC .   ? A GLC 201 ? 1_555 134.3 ? 
49  OD1 ? A ASP 127 ? A ASP 163 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O3  A C GLC .   ? A GLC 201 ? 1_555 145.6 ? 
50  OE1 ? A GLU 102 ? A GLU 138 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O4  A C GLC .   ? A GLC 201 ? 1_555 135.1 ? 
51  OD1 ? A ASN 104 ? A ASN 140 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O4  A C GLC .   ? A GLC 201 ? 1_555 117.2 ? 
52  OE1 ? A GLU 111 ? A GLU 147 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O4  A C GLC .   ? A GLC 201 ? 1_555 74.8  ? 
53  OD1 ? A ASN 126 ? A ASN 162 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O4  A C GLC .   ? A GLC 201 ? 1_555 82.8  ? 
54  O   ? A ASP 127 ? A ASP 163 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O4  A C GLC .   ? A GLC 201 ? 1_555 72.3  ? 
55  OD1 ? A ASP 127 ? A ASP 163 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O4  A C GLC .   ? A GLC 201 ? 1_555 147.3 ? 
56  O3  A C GLC .   ? A GLC 201 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O4  A C GLC .   ? A GLC 201 ? 1_555 66.8  ? 
57  OE1 ? A GLU 102 ? A GLU 138 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O3  B D BGC .   ? A BGC 202 ? 1_555 135.3 ? 
58  OD1 ? A ASN 104 ? A ASN 140 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O3  B D BGC .   ? A BGC 202 ? 1_555 118.3 ? 
59  OE1 ? A GLU 111 ? A GLU 147 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O3  B D BGC .   ? A BGC 202 ? 1_555 75.1  ? 
60  OD1 ? A ASN 126 ? A ASN 162 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O3  B D BGC .   ? A BGC 202 ? 1_555 82.1  ? 
61  O   ? A ASP 127 ? A ASP 163 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O3  B D BGC .   ? A BGC 202 ? 1_555 71.3  ? 
62  OD1 ? A ASP 127 ? A ASP 163 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O3  B D BGC .   ? A BGC 202 ? 1_555 146.4 ? 
63  O3  A C GLC .   ? A GLC 201 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O3  B D BGC .   ? A BGC 202 ? 1_555 67.6  ? 
64  O4  A C GLC .   ? A GLC 201 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O3  B D BGC .   ? A BGC 202 ? 1_555 1.1   ? 
65  OE1 ? A GLU 102 ? A GLU 138 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O4  B D BGC .   ? A BGC 202 ? 1_555 73.1  ? 
66  OD1 ? A ASN 104 ? A ASN 140 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O4  B D BGC .   ? A BGC 202 ? 1_555 77.2  ? 
67  OE1 ? A GLU 111 ? A GLU 147 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O4  B D BGC .   ? A BGC 202 ? 1_555 114.9 ? 
68  OD1 ? A ASN 126 ? A ASN 162 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O4  B D BGC .   ? A BGC 202 ? 1_555 77.7  ? 
69  O   ? A ASP 127 ? A ASP 163 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O4  B D BGC .   ? A BGC 202 ? 1_555 134.0 ? 
70  OD1 ? A ASP 127 ? A ASP 163 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O4  B D BGC .   ? A BGC 202 ? 1_555 144.9 ? 
71  O3  A C GLC .   ? A GLC 201 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O4  B D BGC .   ? A BGC 202 ? 1_555 1.6   ? 
72  O4  A C GLC .   ? A GLC 201 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O4  B D BGC .   ? A BGC 202 ? 1_555 67.4  ? 
73  O3  B D BGC .   ? A BGC 202 ? 1_555 CA ? F CA . ? A CA 204 ? 1_555 O4  B D BGC .   ? A BGC 202 ? 1_555 68.1  ? 
74  O   ? B ILE 55  ? E ILE 91  ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 OD1 ? B ASN 57  ? E ASN 93  ? 1_555 78.9  ? 
75  O   ? B ILE 55  ? E ILE 91  ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 OE1 ? B GLU 61  ? E GLU 97  ? 1_555 74.1  ? 
76  OD1 ? B ASN 57  ? E ASN 93  ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 OE1 ? B GLU 61  ? E GLU 97  ? 1_555 82.0  ? 
77  O   ? B ILE 55  ? E ILE 91  ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 OE2 ? B GLU 61  ? E GLU 97  ? 1_555 83.3  ? 
78  OD1 ? B ASN 57  ? E ASN 93  ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 OE2 ? B GLU 61  ? E GLU 97  ? 1_555 131.5 ? 
79  OE1 ? B GLU 61  ? E GLU 97  ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 OE2 ? B GLU 61  ? E GLU 97  ? 1_555 49.7  ? 
80  O   ? B ILE 55  ? E ILE 91  ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 OE1 ? B GLU 139 ? E GLU 175 ? 1_555 77.6  ? 
81  OD1 ? B ASN 57  ? E ASN 93  ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 OE1 ? B GLU 139 ? E GLU 175 ? 1_555 135.5 ? 
82  OE1 ? B GLU 61  ? E GLU 97  ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 OE1 ? B GLU 139 ? E GLU 175 ? 1_555 125.9 ? 
83  OE2 ? B GLU 61  ? E GLU 97  ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 OE1 ? B GLU 139 ? E GLU 175 ? 1_555 82.2  ? 
84  O   ? B ILE 55  ? E ILE 91  ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 OE2 ? B GLU 139 ? E GLU 175 ? 1_555 129.1 ? 
85  OD1 ? B ASN 57  ? E ASN 93  ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 OE2 ? B GLU 139 ? E GLU 175 ? 1_555 142.3 ? 
86  OE1 ? B GLU 61  ? E GLU 97  ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 OE2 ? B GLU 139 ? E GLU 175 ? 1_555 125.9 ? 
87  OE2 ? B GLU 61  ? E GLU 97  ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 OE2 ? B GLU 139 ? E GLU 175 ? 1_555 81.8  ? 
88  OE1 ? B GLU 139 ? E GLU 175 ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 OE2 ? B GLU 139 ? E GLU 175 ? 1_555 52.3  ? 
89  O   ? B ILE 55  ? E ILE 91  ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 O   ? L HOH .   ? E HOH 346 ? 1_555 104.3 ? 
90  OD1 ? B ASN 57  ? E ASN 93  ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 O   ? L HOH .   ? E HOH 346 ? 1_555 73.9  ? 
91  OE1 ? B GLU 61  ? E GLU 97  ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 O   ? L HOH .   ? E HOH 346 ? 1_555 155.6 ? 
92  OE2 ? B GLU 61  ? E GLU 97  ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 O   ? L HOH .   ? E HOH 346 ? 1_555 154.6 ? 
93  OE1 ? B GLU 139 ? E GLU 175 ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 O   ? L HOH .   ? E HOH 346 ? 1_555 76.0  ? 
94  OE2 ? B GLU 139 ? E GLU 175 ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 O   ? L HOH .   ? E HOH 346 ? 1_555 74.6  ? 
95  O   ? B ILE 55  ? E ILE 91  ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 O   ? L HOH .   ? E HOH 352 ? 1_555 148.4 ? 
96  OD1 ? B ASN 57  ? E ASN 93  ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 O   ? L HOH .   ? E HOH 352 ? 1_555 83.3  ? 
97  OE1 ? B GLU 61  ? E GLU 97  ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 O   ? L HOH .   ? E HOH 352 ? 1_555 77.8  ? 
98  OE2 ? B GLU 61  ? E GLU 97  ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 O   ? L HOH .   ? E HOH 352 ? 1_555 89.3  ? 
99  OE1 ? B GLU 139 ? E GLU 175 ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 O   ? L HOH .   ? E HOH 352 ? 1_555 131.8 ? 
100 OE2 ? B GLU 139 ? E GLU 175 ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 O   ? L HOH .   ? E HOH 352 ? 1_555 79.6  ? 
101 O   ? L HOH .   ? E HOH 346 ? 1_555 CA ? I CA . ? E CA 203 ? 1_555 O   ? L HOH .   ? E HOH 352 ? 1_555 95.5  ? 
102 OE1 ? B GLU 102 ? E GLU 138 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 OD1 ? B ASN 104 ? E ASN 140 ? 1_555 72.0  ? 
103 OE1 ? B GLU 102 ? E GLU 138 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 OE1 ? B GLU 111 ? E GLU 147 ? 1_555 144.7 ? 
104 OD1 ? B ASN 104 ? E ASN 140 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 OE1 ? B GLU 111 ? E GLU 147 ? 1_555 76.4  ? 
105 OE1 ? B GLU 102 ? E GLU 138 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 OD1 ? B ASN 126 ? E ASN 162 ? 1_555 69.2  ? 
106 OD1 ? B ASN 104 ? E ASN 140 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 OD1 ? B ASN 126 ? E ASN 162 ? 1_555 139.4 ? 
107 OE1 ? B GLU 111 ? E GLU 147 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 OD1 ? B ASN 126 ? E ASN 162 ? 1_555 144.2 ? 
108 OE1 ? B GLU 102 ? E GLU 138 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O   ? B ASP 127 ? E ASP 163 ? 1_555 129.5 ? 
109 OD1 ? B ASN 104 ? E ASN 140 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O   ? B ASP 127 ? E ASP 163 ? 1_555 142.1 ? 
110 OE1 ? B GLU 111 ? E GLU 147 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O   ? B ASP 127 ? E ASP 163 ? 1_555 71.2  ? 
111 OD1 ? B ASN 126 ? E ASN 162 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O   ? B ASP 127 ? E ASP 163 ? 1_555 75.3  ? 
112 OE1 ? B GLU 102 ? E GLU 138 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 OD1 ? B ASP 127 ? E ASP 163 ? 1_555 73.2  ? 
113 OD1 ? B ASN 104 ? E ASN 140 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 OD1 ? B ASP 127 ? E ASP 163 ? 1_555 83.3  ? 
114 OE1 ? B GLU 111 ? E GLU 147 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 OD1 ? B ASP 127 ? E ASP 163 ? 1_555 88.0  ? 
115 OD1 ? B ASN 126 ? E ASN 162 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 OD1 ? B ASP 127 ? E ASP 163 ? 1_555 96.4  ? 
116 O   ? B ASP 127 ? E ASP 163 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 OD1 ? B ASP 127 ? E ASP 163 ? 1_555 76.4  ? 
117 OE1 ? B GLU 102 ? E GLU 138 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O3  A G GLC .   ? E GLC 201 ? 1_555 75.2  ? 
118 OD1 ? B ASN 104 ? E ASN 140 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O3  A G GLC .   ? E GLC 201 ? 1_555 76.0  ? 
119 OE1 ? B GLU 111 ? E GLU 147 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O3  A G GLC .   ? E GLC 201 ? 1_555 112.0 ? 
120 OD1 ? B ASN 126 ? E ASN 162 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O3  A G GLC .   ? E GLC 201 ? 1_555 83.1  ? 
121 O   ? B ASP 127 ? E ASP 163 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O3  A G GLC .   ? E GLC 201 ? 1_555 134.7 ? 
122 OD1 ? B ASP 127 ? E ASP 163 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O3  A G GLC .   ? E GLC 201 ? 1_555 146.3 ? 
123 OE1 ? B GLU 102 ? E GLU 138 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O4  A G GLC .   ? E GLC 201 ? 1_555 133.9 ? 
124 OD1 ? B ASN 104 ? E ASN 140 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O4  A G GLC .   ? E GLC 201 ? 1_555 119.0 ? 
125 OE1 ? B GLU 111 ? E GLU 147 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O4  A G GLC .   ? E GLC 201 ? 1_555 75.9  ? 
126 OD1 ? B ASN 126 ? E ASN 162 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O4  A G GLC .   ? E GLC 201 ? 1_555 81.7  ? 
127 O   ? B ASP 127 ? E ASP 163 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O4  A G GLC .   ? E GLC 201 ? 1_555 71.6  ? 
128 OD1 ? B ASP 127 ? E ASP 163 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O4  A G GLC .   ? E GLC 201 ? 1_555 147.3 ? 
129 O3  A G GLC .   ? E GLC 201 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O4  A G GLC .   ? E GLC 201 ? 1_555 66.2  ? 
130 OE1 ? B GLU 102 ? E GLU 138 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O3  B H BGC .   ? E BGC 202 ? 1_555 136.3 ? 
131 OD1 ? B ASN 104 ? E ASN 140 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O3  B H BGC .   ? E BGC 202 ? 1_555 118.8 ? 
132 OE1 ? B GLU 111 ? E GLU 147 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O3  B H BGC .   ? E BGC 202 ? 1_555 73.7  ? 
133 OD1 ? B ASN 126 ? E ASN 162 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O3  B H BGC .   ? E BGC 202 ? 1_555 83.3  ? 
134 O   ? B ASP 127 ? E ASP 163 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O3  B H BGC .   ? E BGC 202 ? 1_555 70.1  ? 
135 OD1 ? B ASP 127 ? E ASP 163 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O3  B H BGC .   ? E BGC 202 ? 1_555 145.5 ? 
136 O3  A G GLC .   ? E GLC 201 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O3  B H BGC .   ? E BGC 202 ? 1_555 68.1  ? 
137 O4  A G GLC .   ? E GLC 201 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O3  B H BGC .   ? E BGC 202 ? 1_555 2.4   ? 
138 OE1 ? B GLU 102 ? E GLU 138 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O4  B H BGC .   ? E BGC 202 ? 1_555 74.0  ? 
139 OD1 ? B ASN 104 ? E ASN 140 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O4  B H BGC .   ? E BGC 202 ? 1_555 77.0  ? 
140 OE1 ? B GLU 111 ? E GLU 147 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O4  B H BGC .   ? E BGC 202 ? 1_555 113.8 ? 
141 OD1 ? B ASN 126 ? E ASN 162 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O4  B H BGC .   ? E BGC 202 ? 1_555 81.3  ? 
142 O   ? B ASP 127 ? E ASP 163 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O4  B H BGC .   ? E BGC 202 ? 1_555 134.4 ? 
143 OD1 ? B ASP 127 ? E ASP 163 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O4  B H BGC .   ? E BGC 202 ? 1_555 145.6 ? 
144 O3  A G GLC .   ? E GLC 201 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O4  B H BGC .   ? E BGC 202 ? 1_555 1.9   ? 
145 O4  A G GLC .   ? E GLC 201 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O4  B H BGC .   ? E BGC 202 ? 1_555 66.7  ? 
146 O3  B H BGC .   ? E BGC 202 ? 1_555 CA ? J CA . ? E CA 204 ? 1_555 O4  B H BGC .   ? E BGC 202 ? 1_555 68.7  ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 46  ? CYS A 138 ? CYS A 82  ? 1_555 CYS A 174 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 113 ? CYS A 130 ? CYS A 149 ? 1_555 CYS A 166 ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS B 46  ? CYS B 138 ? CYS E 82  ? 1_555 CYS E 174 ? 1_555 SG SG . . . None 'Disulfide bridge' 
4 CYS B 113 ? CYS B 130 ? CYS E 149 ? 1_555 CYS E 166 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 GLU 102 A . ? GLU 138 A PRO 103 A ? PRO 139 A 1 0.03  
2 GLU 102 B . ? GLU 138 E PRO 103 B ? PRO 139 E 1 -3.66 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 5 ? 
AA3 ? 5 ? 
AA4 ? 5 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? parallel      
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? parallel      
AA3 4 5 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? parallel      
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 23  ? PHE A 25  ? PHE A 59  PHE A 61  
AA1 2 SER A 28  ? ILE A 32  ? SER A 64  ILE A 68  
AA1 3 PHE A 135 ? ARG A 141 ? PHE A 171 ARG A 177 
AA1 4 LEU A 72  ? GLU A 78  ? LEU A 108 GLU A 114 
AA1 5 TRP A 85  ? TRP A 87  ? TRP A 121 TRP A 123 
AA2 1 ASP A 52  ? LEU A 53  ? ASP A 88  LEU A 89  
AA2 2 PHE A 135 ? ARG A 141 ? PHE A 171 ARG A 177 
AA2 3 LEU A 72  ? GLU A 78  ? LEU A 108 GLU A 114 
AA2 4 CYS A 113 ? ARG A 119 ? CYS A 149 ARG A 155 
AA2 5 LYS A 122 ? LEU A 128 ? LYS A 158 LEU A 164 
AA3 1 PHE B 23  ? PHE B 25  ? PHE E 59  PHE E 61  
AA3 2 SER B 28  ? ILE B 32  ? SER E 64  ILE E 68  
AA3 3 PHE B 135 ? ARG B 141 ? PHE E 171 ARG E 177 
AA3 4 LEU B 72  ? GLU B 78  ? LEU E 108 GLU E 114 
AA3 5 TRP B 85  ? TRP B 87  ? TRP E 121 TRP E 123 
AA4 1 ASP B 52  ? LEU B 53  ? ASP E 88  LEU E 89  
AA4 2 PHE B 135 ? ARG B 141 ? PHE E 171 ARG E 177 
AA4 3 LEU B 72  ? GLU B 78  ? LEU E 108 GLU E 114 
AA4 4 CYS B 113 ? ARG B 119 ? CYS E 149 ARG E 155 
AA4 5 LYS B 122 ? LEU B 128 ? LYS E 158 LEU E 164 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N PHE A 23  ? N PHE A 59  O TYR A 30  ? O TYR A 66  
AA1 2 3 N LEU A 29  ? N LEU A 65  O LYS A 140 ? O LYS A 176 
AA1 3 4 O PHE A 135 ? O PHE A 171 N TRP A 73  ? N TRP A 109 
AA1 4 5 N MET A 77  ? N MET A 113 O ARG A 86  ? O ARG A 122 
AA2 1 2 N ASP A 52  ? N ASP A 88  O GLU A 139 ? O GLU A 175 
AA2 2 3 O PHE A 135 ? O PHE A 171 N TRP A 73  ? N TRP A 109 
AA2 3 4 N LEU A 72  ? N LEU A 108 O GLN A 116 ? O GLN A 152 
AA2 4 5 N CYS A 113 ? N CYS A 149 O LEU A 128 ? O LEU A 164 
AA3 1 2 N PHE B 23  ? N PHE E 59  O TYR B 30  ? O TYR E 66  
AA3 2 3 N LEU B 29  ? N LEU E 65  O LYS B 140 ? O LYS E 176 
AA3 3 4 O PHE B 135 ? O PHE E 171 N TRP B 73  ? N TRP E 109 
AA3 4 5 N MET B 77  ? N MET E 113 O ARG B 86  ? O ARG E 122 
AA4 1 2 N ASP B 52  ? N ASP E 88  O GLU B 139 ? O GLU E 175 
AA4 2 3 O PHE B 135 ? O PHE E 171 N TRP B 73  ? N TRP E 109 
AA4 3 4 N LEU B 72  ? N LEU E 108 O GLN B 116 ? O GLN E 152 
AA4 4 5 N ILE B 117 ? N ILE E 153 O GLY B 124 ? O GLY E 160 
# 
_pdbx_entry_details.entry_id                   9KPL 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O E HOH 311 ? ? O E HOH 330 ? ? 2.16 
2 1 O A HOH 394 ? ? O E HOH 348 ? ? 2.18 
# 
loop_
_pdbx_validate_rmsd_bond.id 
_pdbx_validate_rmsd_bond.PDB_model_num 
_pdbx_validate_rmsd_bond.auth_atom_id_1 
_pdbx_validate_rmsd_bond.auth_asym_id_1 
_pdbx_validate_rmsd_bond.auth_comp_id_1 
_pdbx_validate_rmsd_bond.auth_seq_id_1 
_pdbx_validate_rmsd_bond.PDB_ins_code_1 
_pdbx_validate_rmsd_bond.label_alt_id_1 
_pdbx_validate_rmsd_bond.auth_atom_id_2 
_pdbx_validate_rmsd_bond.auth_asym_id_2 
_pdbx_validate_rmsd_bond.auth_comp_id_2 
_pdbx_validate_rmsd_bond.auth_seq_id_2 
_pdbx_validate_rmsd_bond.PDB_ins_code_2 
_pdbx_validate_rmsd_bond.label_alt_id_2 
_pdbx_validate_rmsd_bond.bond_value 
_pdbx_validate_rmsd_bond.bond_target_value 
_pdbx_validate_rmsd_bond.bond_deviation 
_pdbx_validate_rmsd_bond.bond_standard_deviation 
_pdbx_validate_rmsd_bond.linker_flag 
1 1 CB E VAL 165 ? B CG2 E VAL 165 ? B 1.299 1.524 -0.225 0.021 N 
2 1 CG E GLU 167 ? ? CD  E GLU 167 ? ? 1.621 1.515 0.106  0.015 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ALA A 87  ? ? -143.39 -153.51 
2 1 ARG A 116 ? ? 53.67   -126.41 
3 1 THR A 130 ? ? -112.39 -86.19  
4 1 GLN E 62  ? ? 59.18   -124.45 
5 1 ARG E 116 ? ? 56.40   -124.84 
6 1 THR E 130 ? ? -117.91 -83.79  
7 1 ASN E 140 ? ? -143.54 -2.43   
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z       
2 -x,y+1/2,-z 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 37 ? A MET 1  
2  1 Y 1 A ASN 38 ? A ASN 2  
3  1 Y 1 A GLY 39 ? A GLY 3  
4  1 Y 1 A THR 40 ? A THR 4  
5  1 Y 1 A ALA 41 ? A ALA 5  
6  1 Y 1 A GLU 42 ? A GLU 6  
7  1 Y 1 A GLU 43 ? A GLU 7  
8  1 Y 1 A ARG 44 ? A ARG 8  
9  1 Y 1 A ASN 45 ? A ASN 9  
10 1 Y 1 A LYS 46 ? A LYS 10 
11 1 Y 1 E MET 37 ? B MET 1  
12 1 Y 1 E ASN 38 ? B ASN 2  
13 1 Y 1 E GLY 39 ? B GLY 3  
14 1 Y 1 E THR 40 ? B THR 4  
15 1 Y 1 E ALA 41 ? B ALA 5  
16 1 Y 1 E GLU 42 ? B GLU 6  
17 1 Y 1 E GLU 43 ? B GLU 7  
18 1 Y 1 E ARG 44 ? B ARG 8  
19 1 Y 1 E ASN 45 ? B ASN 9  
20 1 Y 1 E LYS 46 ? B LYS 10 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
BGC C2   C  N R 74  
BGC C3   C  N S 75  
BGC C4   C  N S 76  
BGC C5   C  N R 77  
BGC C6   C  N N 78  
BGC C1   C  N R 79  
BGC O1   O  N N 80  
BGC O2   O  N N 81  
BGC O3   O  N N 82  
BGC O4   O  N N 83  
BGC O5   O  N N 84  
BGC O6   O  N N 85  
BGC H2   H  N N 86  
BGC H3   H  N N 87  
BGC H4   H  N N 88  
BGC H5   H  N N 89  
BGC H61  H  N N 90  
BGC H62  H  N N 91  
BGC H1   H  N N 92  
BGC HO1  H  N N 93  
BGC HO2  H  N N 94  
BGC HO3  H  N N 95  
BGC HO4  H  N N 96  
BGC HO6  H  N N 97  
CA  CA   CA N N 98  
CYS N    N  N N 99  
CYS CA   C  N R 100 
CYS C    C  N N 101 
CYS O    O  N N 102 
CYS CB   C  N N 103 
CYS SG   S  N N 104 
CYS OXT  O  N N 105 
CYS H    H  N N 106 
CYS H2   H  N N 107 
CYS HA   H  N N 108 
CYS HB2  H  N N 109 
CYS HB3  H  N N 110 
CYS HG   H  N N 111 
CYS HXT  H  N N 112 
GLC C1   C  N S 113 
GLC C2   C  N R 114 
GLC C3   C  N S 115 
GLC C4   C  N S 116 
GLC C5   C  N R 117 
GLC C6   C  N N 118 
GLC O1   O  N N 119 
GLC O2   O  N N 120 
GLC O3   O  N N 121 
GLC O4   O  N N 122 
GLC O5   O  N N 123 
GLC O6   O  N N 124 
GLC H1   H  N N 125 
GLC H2   H  N N 126 
GLC H3   H  N N 127 
GLC H4   H  N N 128 
GLC H5   H  N N 129 
GLC H61  H  N N 130 
GLC H62  H  N N 131 
GLC HO1  H  N N 132 
GLC HO2  H  N N 133 
GLC HO3  H  N N 134 
GLC HO4  H  N N 135 
GLC HO6  H  N N 136 
GLN N    N  N N 137 
GLN CA   C  N S 138 
GLN C    C  N N 139 
GLN O    O  N N 140 
GLN CB   C  N N 141 
GLN CG   C  N N 142 
GLN CD   C  N N 143 
GLN OE1  O  N N 144 
GLN NE2  N  N N 145 
GLN OXT  O  N N 146 
GLN H    H  N N 147 
GLN H2   H  N N 148 
GLN HA   H  N N 149 
GLN HB2  H  N N 150 
GLN HB3  H  N N 151 
GLN HG2  H  N N 152 
GLN HG3  H  N N 153 
GLN HE21 H  N N 154 
GLN HE22 H  N N 155 
GLN HXT  H  N N 156 
GLU N    N  N N 157 
GLU CA   C  N S 158 
GLU C    C  N N 159 
GLU O    O  N N 160 
GLU CB   C  N N 161 
GLU CG   C  N N 162 
GLU CD   C  N N 163 
GLU OE1  O  N N 164 
GLU OE2  O  N N 165 
GLU OXT  O  N N 166 
GLU H    H  N N 167 
GLU H2   H  N N 168 
GLU HA   H  N N 169 
GLU HB2  H  N N 170 
GLU HB3  H  N N 171 
GLU HG2  H  N N 172 
GLU HG3  H  N N 173 
GLU HE2  H  N N 174 
GLU HXT  H  N N 175 
GLY N    N  N N 176 
GLY CA   C  N N 177 
GLY C    C  N N 178 
GLY O    O  N N 179 
GLY OXT  O  N N 180 
GLY H    H  N N 181 
GLY H2   H  N N 182 
GLY HA2  H  N N 183 
GLY HA3  H  N N 184 
GLY HXT  H  N N 185 
HIS N    N  N N 186 
HIS CA   C  N S 187 
HIS C    C  N N 188 
HIS O    O  N N 189 
HIS CB   C  N N 190 
HIS CG   C  Y N 191 
HIS ND1  N  Y N 192 
HIS CD2  C  Y N 193 
HIS CE1  C  Y N 194 
HIS NE2  N  Y N 195 
HIS OXT  O  N N 196 
HIS H    H  N N 197 
HIS H2   H  N N 198 
HIS HA   H  N N 199 
HIS HB2  H  N N 200 
HIS HB3  H  N N 201 
HIS HD1  H  N N 202 
HIS HD2  H  N N 203 
HIS HE1  H  N N 204 
HIS HE2  H  N N 205 
HIS HXT  H  N N 206 
HOH O    O  N N 207 
HOH H1   H  N N 208 
HOH H2   H  N N 209 
ILE N    N  N N 210 
ILE CA   C  N S 211 
ILE C    C  N N 212 
ILE O    O  N N 213 
ILE CB   C  N S 214 
ILE CG1  C  N N 215 
ILE CG2  C  N N 216 
ILE CD1  C  N N 217 
ILE OXT  O  N N 218 
ILE H    H  N N 219 
ILE H2   H  N N 220 
ILE HA   H  N N 221 
ILE HB   H  N N 222 
ILE HG12 H  N N 223 
ILE HG13 H  N N 224 
ILE HG21 H  N N 225 
ILE HG22 H  N N 226 
ILE HG23 H  N N 227 
ILE HD11 H  N N 228 
ILE HD12 H  N N 229 
ILE HD13 H  N N 230 
ILE HXT  H  N N 231 
LEU N    N  N N 232 
LEU CA   C  N S 233 
LEU C    C  N N 234 
LEU O    O  N N 235 
LEU CB   C  N N 236 
LEU CG   C  N N 237 
LEU CD1  C  N N 238 
LEU CD2  C  N N 239 
LEU OXT  O  N N 240 
LEU H    H  N N 241 
LEU H2   H  N N 242 
LEU HA   H  N N 243 
LEU HB2  H  N N 244 
LEU HB3  H  N N 245 
LEU HG   H  N N 246 
LEU HD11 H  N N 247 
LEU HD12 H  N N 248 
LEU HD13 H  N N 249 
LEU HD21 H  N N 250 
LEU HD22 H  N N 251 
LEU HD23 H  N N 252 
LEU HXT  H  N N 253 
LYS N    N  N N 254 
LYS CA   C  N S 255 
LYS C    C  N N 256 
LYS O    O  N N 257 
LYS CB   C  N N 258 
LYS CG   C  N N 259 
LYS CD   C  N N 260 
LYS CE   C  N N 261 
LYS NZ   N  N N 262 
LYS OXT  O  N N 263 
LYS H    H  N N 264 
LYS H2   H  N N 265 
LYS HA   H  N N 266 
LYS HB2  H  N N 267 
LYS HB3  H  N N 268 
LYS HG2  H  N N 269 
LYS HG3  H  N N 270 
LYS HD2  H  N N 271 
LYS HD3  H  N N 272 
LYS HE2  H  N N 273 
LYS HE3  H  N N 274 
LYS HZ1  H  N N 275 
LYS HZ2  H  N N 276 
LYS HZ3  H  N N 277 
LYS HXT  H  N N 278 
MET N    N  N N 279 
MET CA   C  N S 280 
MET C    C  N N 281 
MET O    O  N N 282 
MET CB   C  N N 283 
MET CG   C  N N 284 
MET SD   S  N N 285 
MET CE   C  N N 286 
MET OXT  O  N N 287 
MET H    H  N N 288 
MET H2   H  N N 289 
MET HA   H  N N 290 
MET HB2  H  N N 291 
MET HB3  H  N N 292 
MET HG2  H  N N 293 
MET HG3  H  N N 294 
MET HE1  H  N N 295 
MET HE2  H  N N 296 
MET HE3  H  N N 297 
MET HXT  H  N N 298 
PHE N    N  N N 299 
PHE CA   C  N S 300 
PHE C    C  N N 301 
PHE O    O  N N 302 
PHE CB   C  N N 303 
PHE CG   C  Y N 304 
PHE CD1  C  Y N 305 
PHE CD2  C  Y N 306 
PHE CE1  C  Y N 307 
PHE CE2  C  Y N 308 
PHE CZ   C  Y N 309 
PHE OXT  O  N N 310 
PHE H    H  N N 311 
PHE H2   H  N N 312 
PHE HA   H  N N 313 
PHE HB2  H  N N 314 
PHE HB3  H  N N 315 
PHE HD1  H  N N 316 
PHE HD2  H  N N 317 
PHE HE1  H  N N 318 
PHE HE2  H  N N 319 
PHE HZ   H  N N 320 
PHE HXT  H  N N 321 
PRO N    N  N N 322 
PRO CA   C  N S 323 
PRO C    C  N N 324 
PRO O    O  N N 325 
PRO CB   C  N N 326 
PRO CG   C  N N 327 
PRO CD   C  N N 328 
PRO OXT  O  N N 329 
PRO H    H  N N 330 
PRO HA   H  N N 331 
PRO HB2  H  N N 332 
PRO HB3  H  N N 333 
PRO HG2  H  N N 334 
PRO HG3  H  N N 335 
PRO HD2  H  N N 336 
PRO HD3  H  N N 337 
PRO HXT  H  N N 338 
SER N    N  N N 339 
SER CA   C  N S 340 
SER C    C  N N 341 
SER O    O  N N 342 
SER CB   C  N N 343 
SER OG   O  N N 344 
SER OXT  O  N N 345 
SER H    H  N N 346 
SER H2   H  N N 347 
SER HA   H  N N 348 
SER HB2  H  N N 349 
SER HB3  H  N N 350 
SER HG   H  N N 351 
SER HXT  H  N N 352 
THR N    N  N N 353 
THR CA   C  N S 354 
THR C    C  N N 355 
THR O    O  N N 356 
THR CB   C  N R 357 
THR OG1  O  N N 358 
THR CG2  C  N N 359 
THR OXT  O  N N 360 
THR H    H  N N 361 
THR H2   H  N N 362 
THR HA   H  N N 363 
THR HB   H  N N 364 
THR HG1  H  N N 365 
THR HG21 H  N N 366 
THR HG22 H  N N 367 
THR HG23 H  N N 368 
THR HXT  H  N N 369 
TRP N    N  N N 370 
TRP CA   C  N S 371 
TRP C    C  N N 372 
TRP O    O  N N 373 
TRP CB   C  N N 374 
TRP CG   C  Y N 375 
TRP CD1  C  Y N 376 
TRP CD2  C  Y N 377 
TRP NE1  N  Y N 378 
TRP CE2  C  Y N 379 
TRP CE3  C  Y N 380 
TRP CZ2  C  Y N 381 
TRP CZ3  C  Y N 382 
TRP CH2  C  Y N 383 
TRP OXT  O  N N 384 
TRP H    H  N N 385 
TRP H2   H  N N 386 
TRP HA   H  N N 387 
TRP HB2  H  N N 388 
TRP HB3  H  N N 389 
TRP HD1  H  N N 390 
TRP HE1  H  N N 391 
TRP HE3  H  N N 392 
TRP HZ2  H  N N 393 
TRP HZ3  H  N N 394 
TRP HH2  H  N N 395 
TRP HXT  H  N N 396 
TYR N    N  N N 397 
TYR CA   C  N S 398 
TYR C    C  N N 399 
TYR O    O  N N 400 
TYR CB   C  N N 401 
TYR CG   C  Y N 402 
TYR CD1  C  Y N 403 
TYR CD2  C  Y N 404 
TYR CE1  C  Y N 405 
TYR CE2  C  Y N 406 
TYR CZ   C  Y N 407 
TYR OH   O  N N 408 
TYR OXT  O  N N 409 
TYR H    H  N N 410 
TYR H2   H  N N 411 
TYR HA   H  N N 412 
TYR HB2  H  N N 413 
TYR HB3  H  N N 414 
TYR HD1  H  N N 415 
TYR HD2  H  N N 416 
TYR HE1  H  N N 417 
TYR HE2  H  N N 418 
TYR HH   H  N N 419 
TYR HXT  H  N N 420 
VAL N    N  N N 421 
VAL CA   C  N S 422 
VAL C    C  N N 423 
VAL O    O  N N 424 
VAL CB   C  N N 425 
VAL CG1  C  N N 426 
VAL CG2  C  N N 427 
VAL OXT  O  N N 428 
VAL H    H  N N 429 
VAL H2   H  N N 430 
VAL HA   H  N N 431 
VAL HB   H  N N 432 
VAL HG11 H  N N 433 
VAL HG12 H  N N 434 
VAL HG13 H  N N 435 
VAL HG21 H  N N 436 
VAL HG22 H  N N 437 
VAL HG23 H  N N 438 
VAL HXT  H  N N 439 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
BGC C2  C3   sing N N 70  
BGC C2  C1   sing N N 71  
BGC C2  O2   sing N N 72  
BGC C2  H2   sing N N 73  
BGC C3  C4   sing N N 74  
BGC C3  O3   sing N N 75  
BGC C3  H3   sing N N 76  
BGC C4  C5   sing N N 77  
BGC C4  O4   sing N N 78  
BGC C4  H4   sing N N 79  
BGC C5  C6   sing N N 80  
BGC C5  O5   sing N N 81  
BGC C5  H5   sing N N 82  
BGC C6  O6   sing N N 83  
BGC C6  H61  sing N N 84  
BGC C6  H62  sing N N 85  
BGC C1  O1   sing N N 86  
BGC C1  O5   sing N N 87  
BGC C1  H1   sing N N 88  
BGC O1  HO1  sing N N 89  
BGC O2  HO2  sing N N 90  
BGC O3  HO3  sing N N 91  
BGC O4  HO4  sing N N 92  
BGC O6  HO6  sing N N 93  
CYS N   CA   sing N N 94  
CYS N   H    sing N N 95  
CYS N   H2   sing N N 96  
CYS CA  C    sing N N 97  
CYS CA  CB   sing N N 98  
CYS CA  HA   sing N N 99  
CYS C   O    doub N N 100 
CYS C   OXT  sing N N 101 
CYS CB  SG   sing N N 102 
CYS CB  HB2  sing N N 103 
CYS CB  HB3  sing N N 104 
CYS SG  HG   sing N N 105 
CYS OXT HXT  sing N N 106 
GLC C1  C2   sing N N 107 
GLC C1  O1   sing N N 108 
GLC C1  O5   sing N N 109 
GLC C1  H1   sing N N 110 
GLC C2  C3   sing N N 111 
GLC C2  O2   sing N N 112 
GLC C2  H2   sing N N 113 
GLC C3  C4   sing N N 114 
GLC C3  O3   sing N N 115 
GLC C3  H3   sing N N 116 
GLC C4  C5   sing N N 117 
GLC C4  O4   sing N N 118 
GLC C4  H4   sing N N 119 
GLC C5  C6   sing N N 120 
GLC C5  O5   sing N N 121 
GLC C5  H5   sing N N 122 
GLC C6  O6   sing N N 123 
GLC C6  H61  sing N N 124 
GLC C6  H62  sing N N 125 
GLC O1  HO1  sing N N 126 
GLC O2  HO2  sing N N 127 
GLC O3  HO3  sing N N 128 
GLC O4  HO4  sing N N 129 
GLC O6  HO6  sing N N 130 
GLN N   CA   sing N N 131 
GLN N   H    sing N N 132 
GLN N   H2   sing N N 133 
GLN CA  C    sing N N 134 
GLN CA  CB   sing N N 135 
GLN CA  HA   sing N N 136 
GLN C   O    doub N N 137 
GLN C   OXT  sing N N 138 
GLN CB  CG   sing N N 139 
GLN CB  HB2  sing N N 140 
GLN CB  HB3  sing N N 141 
GLN CG  CD   sing N N 142 
GLN CG  HG2  sing N N 143 
GLN CG  HG3  sing N N 144 
GLN CD  OE1  doub N N 145 
GLN CD  NE2  sing N N 146 
GLN NE2 HE21 sing N N 147 
GLN NE2 HE22 sing N N 148 
GLN OXT HXT  sing N N 149 
GLU N   CA   sing N N 150 
GLU N   H    sing N N 151 
GLU N   H2   sing N N 152 
GLU CA  C    sing N N 153 
GLU CA  CB   sing N N 154 
GLU CA  HA   sing N N 155 
GLU C   O    doub N N 156 
GLU C   OXT  sing N N 157 
GLU CB  CG   sing N N 158 
GLU CB  HB2  sing N N 159 
GLU CB  HB3  sing N N 160 
GLU CG  CD   sing N N 161 
GLU CG  HG2  sing N N 162 
GLU CG  HG3  sing N N 163 
GLU CD  OE1  doub N N 164 
GLU CD  OE2  sing N N 165 
GLU OE2 HE2  sing N N 166 
GLU OXT HXT  sing N N 167 
GLY N   CA   sing N N 168 
GLY N   H    sing N N 169 
GLY N   H2   sing N N 170 
GLY CA  C    sing N N 171 
GLY CA  HA2  sing N N 172 
GLY CA  HA3  sing N N 173 
GLY C   O    doub N N 174 
GLY C   OXT  sing N N 175 
GLY OXT HXT  sing N N 176 
HIS N   CA   sing N N 177 
HIS N   H    sing N N 178 
HIS N   H2   sing N N 179 
HIS CA  C    sing N N 180 
HIS CA  CB   sing N N 181 
HIS CA  HA   sing N N 182 
HIS C   O    doub N N 183 
HIS C   OXT  sing N N 184 
HIS CB  CG   sing N N 185 
HIS CB  HB2  sing N N 186 
HIS CB  HB3  sing N N 187 
HIS CG  ND1  sing Y N 188 
HIS CG  CD2  doub Y N 189 
HIS ND1 CE1  doub Y N 190 
HIS ND1 HD1  sing N N 191 
HIS CD2 NE2  sing Y N 192 
HIS CD2 HD2  sing N N 193 
HIS CE1 NE2  sing Y N 194 
HIS CE1 HE1  sing N N 195 
HIS NE2 HE2  sing N N 196 
HIS OXT HXT  sing N N 197 
HOH O   H1   sing N N 198 
HOH O   H2   sing N N 199 
ILE N   CA   sing N N 200 
ILE N   H    sing N N 201 
ILE N   H2   sing N N 202 
ILE CA  C    sing N N 203 
ILE CA  CB   sing N N 204 
ILE CA  HA   sing N N 205 
ILE C   O    doub N N 206 
ILE C   OXT  sing N N 207 
ILE CB  CG1  sing N N 208 
ILE CB  CG2  sing N N 209 
ILE CB  HB   sing N N 210 
ILE CG1 CD1  sing N N 211 
ILE CG1 HG12 sing N N 212 
ILE CG1 HG13 sing N N 213 
ILE CG2 HG21 sing N N 214 
ILE CG2 HG22 sing N N 215 
ILE CG2 HG23 sing N N 216 
ILE CD1 HD11 sing N N 217 
ILE CD1 HD12 sing N N 218 
ILE CD1 HD13 sing N N 219 
ILE OXT HXT  sing N N 220 
LEU N   CA   sing N N 221 
LEU N   H    sing N N 222 
LEU N   H2   sing N N 223 
LEU CA  C    sing N N 224 
LEU CA  CB   sing N N 225 
LEU CA  HA   sing N N 226 
LEU C   O    doub N N 227 
LEU C   OXT  sing N N 228 
LEU CB  CG   sing N N 229 
LEU CB  HB2  sing N N 230 
LEU CB  HB3  sing N N 231 
LEU CG  CD1  sing N N 232 
LEU CG  CD2  sing N N 233 
LEU CG  HG   sing N N 234 
LEU CD1 HD11 sing N N 235 
LEU CD1 HD12 sing N N 236 
LEU CD1 HD13 sing N N 237 
LEU CD2 HD21 sing N N 238 
LEU CD2 HD22 sing N N 239 
LEU CD2 HD23 sing N N 240 
LEU OXT HXT  sing N N 241 
LYS N   CA   sing N N 242 
LYS N   H    sing N N 243 
LYS N   H2   sing N N 244 
LYS CA  C    sing N N 245 
LYS CA  CB   sing N N 246 
LYS CA  HA   sing N N 247 
LYS C   O    doub N N 248 
LYS C   OXT  sing N N 249 
LYS CB  CG   sing N N 250 
LYS CB  HB2  sing N N 251 
LYS CB  HB3  sing N N 252 
LYS CG  CD   sing N N 253 
LYS CG  HG2  sing N N 254 
LYS CG  HG3  sing N N 255 
LYS CD  CE   sing N N 256 
LYS CD  HD2  sing N N 257 
LYS CD  HD3  sing N N 258 
LYS CE  NZ   sing N N 259 
LYS CE  HE2  sing N N 260 
LYS CE  HE3  sing N N 261 
LYS NZ  HZ1  sing N N 262 
LYS NZ  HZ2  sing N N 263 
LYS NZ  HZ3  sing N N 264 
LYS OXT HXT  sing N N 265 
MET N   CA   sing N N 266 
MET N   H    sing N N 267 
MET N   H2   sing N N 268 
MET CA  C    sing N N 269 
MET CA  CB   sing N N 270 
MET CA  HA   sing N N 271 
MET C   O    doub N N 272 
MET C   OXT  sing N N 273 
MET CB  CG   sing N N 274 
MET CB  HB2  sing N N 275 
MET CB  HB3  sing N N 276 
MET CG  SD   sing N N 277 
MET CG  HG2  sing N N 278 
MET CG  HG3  sing N N 279 
MET SD  CE   sing N N 280 
MET CE  HE1  sing N N 281 
MET CE  HE2  sing N N 282 
MET CE  HE3  sing N N 283 
MET OXT HXT  sing N N 284 
PHE N   CA   sing N N 285 
PHE N   H    sing N N 286 
PHE N   H2   sing N N 287 
PHE CA  C    sing N N 288 
PHE CA  CB   sing N N 289 
PHE CA  HA   sing N N 290 
PHE C   O    doub N N 291 
PHE C   OXT  sing N N 292 
PHE CB  CG   sing N N 293 
PHE CB  HB2  sing N N 294 
PHE CB  HB3  sing N N 295 
PHE CG  CD1  doub Y N 296 
PHE CG  CD2  sing Y N 297 
PHE CD1 CE1  sing Y N 298 
PHE CD1 HD1  sing N N 299 
PHE CD2 CE2  doub Y N 300 
PHE CD2 HD2  sing N N 301 
PHE CE1 CZ   doub Y N 302 
PHE CE1 HE1  sing N N 303 
PHE CE2 CZ   sing Y N 304 
PHE CE2 HE2  sing N N 305 
PHE CZ  HZ   sing N N 306 
PHE OXT HXT  sing N N 307 
PRO N   CA   sing N N 308 
PRO N   CD   sing N N 309 
PRO N   H    sing N N 310 
PRO CA  C    sing N N 311 
PRO CA  CB   sing N N 312 
PRO CA  HA   sing N N 313 
PRO C   O    doub N N 314 
PRO C   OXT  sing N N 315 
PRO CB  CG   sing N N 316 
PRO CB  HB2  sing N N 317 
PRO CB  HB3  sing N N 318 
PRO CG  CD   sing N N 319 
PRO CG  HG2  sing N N 320 
PRO CG  HG3  sing N N 321 
PRO CD  HD2  sing N N 322 
PRO CD  HD3  sing N N 323 
PRO OXT HXT  sing N N 324 
SER N   CA   sing N N 325 
SER N   H    sing N N 326 
SER N   H2   sing N N 327 
SER CA  C    sing N N 328 
SER CA  CB   sing N N 329 
SER CA  HA   sing N N 330 
SER C   O    doub N N 331 
SER C   OXT  sing N N 332 
SER CB  OG   sing N N 333 
SER CB  HB2  sing N N 334 
SER CB  HB3  sing N N 335 
SER OG  HG   sing N N 336 
SER OXT HXT  sing N N 337 
THR N   CA   sing N N 338 
THR N   H    sing N N 339 
THR N   H2   sing N N 340 
THR CA  C    sing N N 341 
THR CA  CB   sing N N 342 
THR CA  HA   sing N N 343 
THR C   O    doub N N 344 
THR C   OXT  sing N N 345 
THR CB  OG1  sing N N 346 
THR CB  CG2  sing N N 347 
THR CB  HB   sing N N 348 
THR OG1 HG1  sing N N 349 
THR CG2 HG21 sing N N 350 
THR CG2 HG22 sing N N 351 
THR CG2 HG23 sing N N 352 
THR OXT HXT  sing N N 353 
TRP N   CA   sing N N 354 
TRP N   H    sing N N 355 
TRP N   H2   sing N N 356 
TRP CA  C    sing N N 357 
TRP CA  CB   sing N N 358 
TRP CA  HA   sing N N 359 
TRP C   O    doub N N 360 
TRP C   OXT  sing N N 361 
TRP CB  CG   sing N N 362 
TRP CB  HB2  sing N N 363 
TRP CB  HB3  sing N N 364 
TRP CG  CD1  doub Y N 365 
TRP CG  CD2  sing Y N 366 
TRP CD1 NE1  sing Y N 367 
TRP CD1 HD1  sing N N 368 
TRP CD2 CE2  doub Y N 369 
TRP CD2 CE3  sing Y N 370 
TRP NE1 CE2  sing Y N 371 
TRP NE1 HE1  sing N N 372 
TRP CE2 CZ2  sing Y N 373 
TRP CE3 CZ3  doub Y N 374 
TRP CE3 HE3  sing N N 375 
TRP CZ2 CH2  doub Y N 376 
TRP CZ2 HZ2  sing N N 377 
TRP CZ3 CH2  sing Y N 378 
TRP CZ3 HZ3  sing N N 379 
TRP CH2 HH2  sing N N 380 
TRP OXT HXT  sing N N 381 
TYR N   CA   sing N N 382 
TYR N   H    sing N N 383 
TYR N   H2   sing N N 384 
TYR CA  C    sing N N 385 
TYR CA  CB   sing N N 386 
TYR CA  HA   sing N N 387 
TYR C   O    doub N N 388 
TYR C   OXT  sing N N 389 
TYR CB  CG   sing N N 390 
TYR CB  HB2  sing N N 391 
TYR CB  HB3  sing N N 392 
TYR CG  CD1  doub Y N 393 
TYR CG  CD2  sing Y N 394 
TYR CD1 CE1  sing Y N 395 
TYR CD1 HD1  sing N N 396 
TYR CD2 CE2  doub Y N 397 
TYR CD2 HD2  sing N N 398 
TYR CE1 CZ   doub Y N 399 
TYR CE1 HE1  sing N N 400 
TYR CE2 CZ   sing Y N 401 
TYR CE2 HE2  sing N N 402 
TYR CZ  OH   sing N N 403 
TYR OH  HH   sing N N 404 
TYR OXT HXT  sing N N 405 
VAL N   CA   sing N N 406 
VAL N   H    sing N N 407 
VAL N   H2   sing N N 408 
VAL CA  C    sing N N 409 
VAL CA  CB   sing N N 410 
VAL CA  HA   sing N N 411 
VAL C   O    doub N N 412 
VAL C   OXT  sing N N 413 
VAL CB  CG1  sing N N 414 
VAL CB  CG2  sing N N 415 
VAL CB  HB   sing N N 416 
VAL CG1 HG11 sing N N 417 
VAL CG1 HG12 sing N N 418 
VAL CG1 HG13 sing N N 419 
VAL CG2 HG21 sing N N 420 
VAL CG2 HG22 sing N N 421 
VAL CG2 HG23 sing N N 422 
VAL OXT HXT  sing N N 423 
# 
_pdbx_audit_support.funding_organization   'Japan Society for the Promotion of Science (JSPS)' 
_pdbx_audit_support.country                Japan 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 1 21 1' 
_space_group.name_Hall        'P 2yb' 
_space_group.IT_number        4 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9KPL 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.020681 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.009986 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014314 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.021527 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CA ? ? 16.26893 3.65395 ? ? 3.58509  77.28589 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . PHE A 1 11  ? -11.01269 8.68424   1.33261   1.000 52.77310 ? 47  PHE A N   1 
ATOM   2    C  CA  . PHE A 1 11  ? -10.98720 8.75865   2.81424   1.000 48.92768 ? 47  PHE A CA  1 
ATOM   3    C  C   . PHE A 1 11  ? -11.58544 7.52761   3.50613   1.000 47.62825 ? 47  PHE A C   1 
ATOM   4    O  O   . PHE A 1 11  ? -11.09513 7.09282   4.55190   1.000 44.43844 ? 47  PHE A O   1 
ATOM   5    C  CB  . PHE A 1 11  ? -11.72505 9.99592   3.32790   1.000 58.04252 ? 47  PHE A CB  1 
ATOM   6    C  CG  . PHE A 1 11  ? -10.90080 11.24541  3.28557   1.000 63.17549 ? 47  PHE A CG  1 
ATOM   7    C  CD1 . PHE A 1 11  ? -9.76966  11.37225  4.10847   1.000 56.66376 ? 47  PHE A CD1 1 
ATOM   8    C  CD2 . PHE A 1 11  ? -11.24876 12.29692  2.43442   1.000 58.54776 ? 47  PHE A CD2 1 
ATOM   9    C  CE1 . PHE A 1 11  ? -8.98834  12.52951  4.08126   1.000 50.21551 ? 47  PHE A CE1 1 
ATOM   10   C  CE2 . PHE A 1 11  ? -10.48749 13.45642  2.39548   1.000 55.30190 ? 47  PHE A CE2 1 
ATOM   11   C  CZ  . PHE A 1 11  ? -9.34830  13.57581  3.22348   1.000 51.51109 ? 47  PHE A CZ  1 
ATOM   12   N  N   . ASP A 1 12  ? -12.66358 6.96495   2.96637   1.000 45.15562 ? 48  ASP A N   1 
ATOM   13   C  CA  . ASP A 1 12  ? -13.10440 5.69712   3.52631   1.000 47.28486 ? 48  ASP A CA  1 
ATOM   14   C  C   . ASP A 1 12  ? -11.98135 4.68706   3.42708   1.000 41.12488 ? 48  ASP A C   1 
ATOM   15   O  O   . ASP A 1 12  ? -11.79156 3.86666   4.33264   1.000 35.41872 ? 48  ASP A O   1 
ATOM   16   C  CB  . ASP A 1 12  ? -14.35844 5.15283   2.81621   1.000 51.41403 ? 48  ASP A CB  1 
ATOM   17   C  CG  . ASP A 1 12  ? -15.63895 5.91820   3.18093   1.000 60.01561 ? 48  ASP A CG  1 
ATOM   18   O  OD1 . ASP A 1 12  ? -15.72238 6.50446   4.30436   1.000 64.67140 ? 48  ASP A OD1 1 
ATOM   19   O  OD2 . ASP A 1 12  ? -16.56761 5.90461   2.33389   1.000 57.16654 ? 48  ASP A OD2 1 
ATOM   20   N  N   . LYS A 1 13  ? -11.23188 4.72773   2.31919   1.000 34.92902 ? 49  LYS A N   1 
ATOM   21   C  CA  . LYS A 1 13  ? -10.11057 3.81647   2.17218   1.000 34.79065 ? 49  LYS A CA  1 
ATOM   22   C  C   . LYS A 1 13  ? -8.97540  4.23431   3.09234   1.000 33.63667 ? 49  LYS A C   1 
ATOM   23   O  O   . LYS A 1 13  ? -8.32602  3.38585   3.71434   1.000 28.23603 ? 49  LYS A O   1 
ATOM   24   C  CB  . LYS A 1 13  ? -9.62248  3.81803   0.72451   1.000 36.66398 ? 49  LYS A CB  1 
ATOM   25   C  CG  . LYS A 1 13  ? -10.07578 2.68397   -0.18282  1.000 44.79293 ? 49  LYS A CG  1 
ATOM   26   C  CD  . LYS A 1 13  ? -9.92343  3.15118   -1.62964  1.000 46.30608 ? 49  LYS A CD  1 
ATOM   27   C  CE  . LYS A 1 13  ? -11.03588 2.64504   -2.56516  1.000 59.53603 ? 49  LYS A CE  1 
ATOM   28   N  NZ  . LYS A 1 13  ? -10.60715 1.43077   -3.34776  1.000 55.14092 ? 49  LYS A NZ  1 
ATOM   29   N  N   . LEU A 1 14  ? -8.72316  5.54932   3.19002   1.000 28.97780 ? 50  LEU A N   1 
ATOM   30   C  CA  . LEU A 1 14  ? -7.46768  5.97688   3.79676   1.000 29.51021 ? 50  LEU A CA  1 
ATOM   31   C  C   . LEU A 1 14  ? -7.54388  6.09256   5.31215   1.000 27.77922 ? 50  LEU A C   1 
ATOM   32   O  O   . LEU A 1 14  ? -6.54494  5.82918   5.99226   1.000 28.10766 ? 50  LEU A O   1 
ATOM   33   C  CB  . LEU A 1 14  ? -7.01073  7.30775   3.19312   1.000 27.93956 ? 50  LEU A CB  1 
ATOM   34   C  CG  . LEU A 1 14  ? -6.69971  7.37079   1.69155   1.000 27.94222 ? 50  LEU A CG  1 
ATOM   35   C  CD1 . LEU A 1 14  ? -6.15400  8.69893   1.32696   1.000 27.80635 ? 50  LEU A CD1 1 
ATOM   36   C  CD2 . LEU A 1 14  ? -5.72191  6.27849   1.27466   1.000 27.59360 ? 50  LEU A CD2 1 
ATOM   37   N  N   . ASP A 1 15  ? -8.69473  6.50385   5.85938   1.000 27.58976 ? 51  ASP A N   1 
ATOM   38   C  CA  . ASP A 1 15  ? -8.75808  6.84006   7.28232   1.000 28.07491 ? 51  ASP A CA  1 
ATOM   39   C  C   . ASP A 1 15  ? -8.30792  5.71319   8.19720   1.000 28.26137 ? 51  ASP A C   1 
ATOM   40   O  O   . ASP A 1 15  ? -7.64538  6.01114   9.20574   1.000 30.60398 ? 51  ASP A O   1 
ATOM   41   C  CB  . ASP A 1 15  ? -10.17936 7.29810   7.64378   1.000 30.30205 ? 51  ASP A CB  1 
ATOM   42   C  CG  . ASP A 1 15  ? -10.51623 8.70217   7.08705   1.000 41.76076 ? 51  ASP A CG  1 
ATOM   43   O  OD1 . ASP A 1 15  ? -11.68530 9.14937   7.18597   1.000 56.83847 ? 51  ASP A OD1 1 
ATOM   44   O  OD2 . ASP A 1 15  ? -9.59737  9.37982   6.57036   1.000 39.92459 ? 51  ASP A OD2 1 
ATOM   45   N  N   . PRO A 1 16  ? -8.65458  4.44024   7.96845   1.000 27.96558 ? 52  PRO A N   1 
ATOM   46   C  CA  . PRO A 1 16  ? -8.16952  3.41209   8.89453   1.000 27.84789 ? 52  PRO A CA  1 
ATOM   47   C  C   . PRO A 1 16  ? -6.65064  3.34592   8.89287   1.000 25.07949 ? 52  PRO A C   1 
ATOM   48   O  O   . PRO A 1 16  ? -6.03876  3.04941   9.92014   1.000 29.02146 ? 52  PRO A O   1 
ATOM   49   C  CB  . PRO A 1 16  ? -8.79614  2.12702   8.36445   1.000 30.56628 ? 52  PRO A CB  1 
ATOM   50   C  CG  . PRO A 1 16  ? -10.06082 2.63541   7.62277   1.000 32.85143 ? 52  PRO A CG  1 
ATOM   51   C  CD  . PRO A 1 16  ? -9.62185  3.89703   6.99281   1.000 31.13987 ? 52  PRO A CD  1 
ATOM   52   N  N   . TYR A 1 17  ? -6.02422  3.62324   7.74363   1.000 23.06591 ? 53  TYR A N   1 
ATOM   53   C  CA  . TYR A 1 17  ? -4.56714  3.58734   7.68604   1.000 22.44914 ? 53  TYR A CA  1 
ATOM   54   C  C   . TYR A 1 17  ? -3.92786  4.79452   8.37920   1.000 19.86938 ? 53  TYR A C   1 
ATOM   55   O  O   . TYR A 1 17  ? -2.91019  4.65112   9.07488   1.000 20.76069 ? 53  TYR A O   1 
ATOM   56   C  CB  . TYR A 1 17  ? -4.16256  3.51035   6.21887   1.000 22.03160 ? 53  TYR A CB  1 
ATOM   57   C  CG  . TYR A 1 17  ? -4.40953  2.12031   5.64311   1.000 25.42549 ? 53  TYR A CG  1 
ATOM   58   C  CD1 . TYR A 1 17  ? -3.54999  1.07443   5.94687   1.000 25.06591 ? 53  TYR A CD1 1 
ATOM   59   C  CD2 . TYR A 1 17  ? -5.52273  1.85803   4.85017   1.000 27.45422 ? 53  TYR A CD2 1 
ATOM   60   C  CE1 . TYR A 1 17  ? -3.75823  -0.20802  5.44199   1.000 27.09877 ? 53  TYR A CE1 1 
ATOM   61   C  CE2 . TYR A 1 17  ? -5.75027  0.59067   4.33459   1.000 25.17894 ? 53  TYR A CE2 1 
ATOM   62   C  CZ  . TYR A 1 17  ? -4.86008  -0.43172  4.63072   1.000 27.44529 ? 53  TYR A CZ  1 
ATOM   63   O  OH  . TYR A 1 17  ? -5.05789  -1.70020  4.11506   1.000 32.15284 ? 53  TYR A OH  1 
ATOM   64   N  N   . PHE A 1 18  ? -4.45722  5.99488   8.14482   1.000 19.85084 ? 54  PHE A N   1 
ATOM   65   C  CA  . PHE A 1 18  ? -3.97904  7.17142   8.86840   1.000 22.13222 ? 54  PHE A CA  1 
ATOM   66   C  C   . PHE A 1 18  ? -4.02504  6.91379   10.37302  1.000 25.88084 ? 54  PHE A C   1 
ATOM   67   O  O   . PHE A 1 18  ? -3.10261  7.29456   11.13353  1.000 23.04549 ? 54  PHE A O   1 
ATOM   68   C  CB  . PHE A 1 18  ? -4.86834  8.39019   8.55517   1.000 23.81579 ? 54  PHE A CB  1 
ATOM   69   C  CG  . PHE A 1 18  ? -4.77419  8.93152   7.13562   1.000 20.16878 ? 54  PHE A CG  1 
ATOM   70   C  CD1 . PHE A 1 18  ? -3.57111  8.88020   6.38592   1.000 16.97437 ? 54  PHE A CD1 1 
ATOM   71   C  CD2 . PHE A 1 18  ? -5.90218  9.54236   6.57388   1.000 21.72667 ? 54  PHE A CD2 1 
ATOM   72   C  CE1 . PHE A 1 18  ? -3.51837  9.43883   5.11744   1.000 18.35374 ? 54  PHE A CE1 1 
ATOM   73   C  CE2 . PHE A 1 18  ? -5.85232  10.09854  5.31044   1.000 20.61418 ? 54  PHE A CE2 1 
ATOM   74   C  CZ  . PHE A 1 18  ? -4.67425  10.04651  4.56675   1.000 19.22851 ? 54  PHE A CZ  1 
ATOM   75   N  N   . GLN A 1 19  ? -5.10344  6.26538   10.83943  1.000 26.44463 ? 55  GLN A N   1 
ATOM   76   C  CA  . GLN A 1 19  ? -5.14638  6.09427   12.28304  1.000 30.10566 ? 55  GLN A CA  1 
ATOM   77   C  C   . GLN A 1 19  ? -4.04838  5.16313   12.79320  1.000 31.26453 ? 55  GLN A C   1 
ATOM   78   O  O   . GLN A 1 19  ? -3.69203  5.24311   13.97418  1.000 34.47137 ? 55  GLN A O   1 
ATOM   79   C  CB  . GLN A 1 19  ? -6.55396  5.65977   12.70824  1.000 35.27513 ? 55  GLN A CB  1 
ATOM   80   C  CG  . GLN A 1 19  ? -7.54826  6.81949   12.51379  1.000 41.62044 ? 55  GLN A CG  1 
ATOM   81   C  CD  . GLN A 1 19  ? -7.02801  8.17991   13.11290  1.000 57.95858 ? 55  GLN A CD  1 
ATOM   82   O  OE1 . GLN A 1 19  ? -6.97503  8.37136   14.34012  1.000 84.21377 ? 55  GLN A OE1 1 
ATOM   83   N  NE2 . GLN A 1 19  ? -6.63980  9.12159   12.21040  1.000 48.83843 ? 55  GLN A NE2 1 
ATOM   84   N  N   . GLN A 1 20  ? -3.41092  4.38600   11.92172  1.000 29.33964 ? 56  GLN A N   1 
ATOM   85   C  CA  . GLN A 1 20  ? -2.28590  3.55372   12.33014  1.000 26.46087 ? 56  GLN A CA  1 
ATOM   86   C  C   . GLN A 1 20  ? -0.92975  4.14839   11.96860  1.000 26.01911 ? 56  GLN A C   1 
ATOM   87   O  O   . GLN A 1 20  ? 0.08603   3.46110   12.10872  1.000 27.85285 ? 56  GLN A O   1 
ATOM   88   C  CB  . GLN A 1 20  ? -2.42766  2.15689   11.72801  1.000 30.97234 ? 56  GLN A CB  1 
ATOM   89   C  CG  . GLN A 1 20  ? -3.82071  1.58782   11.85946  1.000 35.15904 ? 56  GLN A CG  1 
ATOM   90   C  CD  . GLN A 1 20  ? -3.93673  0.25244   11.17702  1.000 42.70411 ? 56  GLN A CD  1 
ATOM   91   O  OE1 . GLN A 1 20  ? -3.35276  -0.74141  11.62278  1.000 51.87503 ? 56  GLN A OE1 1 
ATOM   92   N  NE2 . GLN A 1 20  ? -4.70230  0.21635   10.06174  1.000 41.90349 ? 56  GLN A NE2 1 
ATOM   93   N  N   . GLY A 1 21  ? -0.88088  5.38742   11.51069  1.000 23.65126 ? 57  GLY A N   1 
ATOM   94   C  CA  . GLY A 1 21  ? 0.38455   6.06170   11.24367  1.000 20.05919 ? 57  GLY A CA  1 
ATOM   95   C  C   . GLY A 1 21  ? 0.85294   5.98314   9.79494   1.000 19.14029 ? 57  GLY A C   1 
ATOM   96   O  O   . GLY A 1 21  ? 1.95200   6.45964   9.49929   1.000 21.69489 ? 57  GLY A O   1 
ATOM   97   N  N   . TRP A 1 22  ? 0.03765   5.44319   8.87391   1.000 19.51093 ? 58  TRP A N   1 
ATOM   98   C  CA  . TRP A 1 22  ? 0.38960   5.50500   7.44334   1.000 16.43787 ? 58  TRP A CA  1 
ATOM   99   C  C   . TRP A 1 22  ? 0.14005   6.88885   6.92601   1.000 17.23464 ? 58  TRP A C   1 
ATOM   100  O  O   . TRP A 1 22  ? -0.68191  7.63403   7.47996   1.000 18.64806 ? 58  TRP A O   1 
ATOM   101  C  CB  . TRP A 1 22  ? -0.47572  4.52798   6.59997   1.000 15.50217 ? 58  TRP A CB  1 
ATOM   102  C  CG  . TRP A 1 22  ? -0.25907  3.11632   6.97536   1.000 19.05475 ? 58  TRP A CG  1 
ATOM   103  C  CD1 . TRP A 1 22  ? -0.68441  2.47963   8.12814   1.000 20.19678 ? 58  TRP A CD1 1 
ATOM   104  C  CD2 . TRP A 1 22  ? 0.40858   2.12212   6.17374   1.000 19.43841 ? 58  TRP A CD2 1 
ATOM   105  N  NE1 . TRP A 1 22  ? -0.26904  1.13814   8.10405   1.000 22.18521 ? 58  TRP A NE1 1 
ATOM   106  C  CE2 . TRP A 1 22  ? 0.38847   0.89803   6.91422   1.000 21.74606 ? 58  TRP A CE2 1 
ATOM   107  C  CE3 . TRP A 1 22  ? 1.01728   2.14712   4.90487   1.000 16.73442 ? 58  TRP A CE3 1 
ATOM   108  C  CZ2 . TRP A 1 22  ? 0.93793   -0.29208  6.40858   1.000 21.39968 ? 58  TRP A CZ2 1 
ATOM   109  C  CZ3 . TRP A 1 22  ? 1.58568   0.95265   4.39918   1.000 15.97790 ? 58  TRP A CZ3 1 
ATOM   110  C  CH2 . TRP A 1 22  ? 1.54450   -0.24101  5.15660   1.000 17.77520 ? 58  TRP A CH2 1 
ATOM   111  N  N   . PHE A 1 23  ? 0.79045   7.23094   5.80866   1.000 15.20626 ? 59  PHE A N   1 
ATOM   112  C  CA  . PHE A 1 23  ? 0.46602   8.50425   5.15786   1.000 13.89987 ? 59  PHE A CA  1 
ATOM   113  C  C   . PHE A 1 23  ? 0.52227   8.32105   3.64433   1.000 16.63772 ? 59  PHE A C   1 
ATOM   114  O  O   . PHE A 1 23  ? 1.05517   7.33253   3.12504   1.000 14.59289 ? 59  PHE A O   1 
ATOM   115  C  CB  . PHE A 1 23  ? 1.40543   9.66836   5.59959   1.000 14.69697 ? 59  PHE A CB  1 
ATOM   116  C  CG  . PHE A 1 23  ? 2.86708   9.26965   5.62485   1.000 14.13609 ? 59  PHE A CG  1 
ATOM   117  C  CD1 . PHE A 1 23  ? 3.39568   8.58589   6.72656   1.000 15.93171 ? 59  PHE A CD1 1 
ATOM   118  C  CD2 . PHE A 1 23  ? 3.69838   9.54432   4.51808   1.000 15.47715 ? 59  PHE A CD2 1 
ATOM   119  C  CE1 . PHE A 1 23  ? 4.75317   8.16915   6.73333   1.000 16.54028 ? 59  PHE A CE1 1 
ATOM   120  C  CE2 . PHE A 1 23  ? 5.04758   9.15306   4.52525   1.000 14.85808 ? 59  PHE A CE2 1 
ATOM   121  C  CZ  . PHE A 1 23  ? 5.57448   8.48024   5.64727   1.000 15.29593 ? 59  PHE A CZ  1 
ATOM   122  N  N   . HIS A 1 24  ? -0.09944  9.26792   2.95176   1.000 14.37369 ? 60  HIS A N   1 
ATOM   123  C  CA  . HIS A 1 24  ? -0.49898  9.14194   1.55089   1.000 14.04677 ? 60  HIS A CA  1 
ATOM   124  C  C   . HIS A 1 24  ? 0.35706   10.03576  0.66813   1.000 14.46507 ? 60  HIS A C   1 
ATOM   125  O  O   . HIS A 1 24  ? 0.47219   11.24384  0.90176   1.000 13.62969 ? 60  HIS A O   1 
ATOM   126  C  CB  . HIS A 1 24  ? -2.02044  9.50894   1.42800   1.000 15.28850 ? 60  HIS A CB  1 
ATOM   127  C  CG  . HIS A 1 24  ? -2.51254  9.68790   0.00919   1.000 17.36277 ? 60  HIS A CG  1 
ATOM   128  N  ND1 . HIS A 1 24  ? -3.49011  10.61275  -0.34632  1.000 19.12942 ? 60  HIS A ND1 1 
ATOM   129  C  CD2 . HIS A 1 24  ? -2.14456  9.06925   -1.14449  1.000 17.04315 ? 60  HIS A CD2 1 
ATOM   130  C  CE1 . HIS A 1 24  ? -3.69774  10.55895  -1.64963  1.000 17.21624 ? 60  HIS A CE1 1 
ATOM   131  N  NE2 . HIS A 1 24  ? -2.89885  9.61841   -2.15698  1.000 17.51544 ? 60  HIS A NE2 1 
ATOM   132  N  N   . PHE A 1 25  ? 0.95083   9.44712   -0.37018  1.000 13.86289 ? 61  PHE A N   1 
ATOM   133  C  CA  . PHE A 1 25  ? 1.64848   10.21316  -1.39325  1.000 13.34010 ? 61  PHE A CA  1 
ATOM   134  C  C   . PHE A 1 25  ? 1.33260   9.58708   -2.75193  1.000 15.80400 ? 61  PHE A C   1 
ATOM   135  O  O   . PHE A 1 25  ? 1.56261   8.40561   -2.93281  1.000 12.93308 ? 61  PHE A O   1 
ATOM   136  C  CB  . PHE A 1 25  ? 3.17444   10.19489  -1.07432  1.000 15.39088 ? 61  PHE A CB  1 
ATOM   137  C  CG  . PHE A 1 25  ? 4.02051   10.83595  -2.14282  1.000 17.18746 ? 61  PHE A CG  1 
ATOM   138  C  CD1 . PHE A 1 25  ? 4.15905   12.23518  -2.20192  1.000 14.52535 ? 61  PHE A CD1 1 
ATOM   139  C  CD2 . PHE A 1 25  ? 4.66593   10.05168  -3.10320  1.000 17.33963 ? 61  PHE A CD2 1 
ATOM   140  C  CE1 . PHE A 1 25  ? 4.89569   12.84549  -3.20925  1.000 16.52775 ? 61  PHE A CE1 1 
ATOM   141  C  CE2 . PHE A 1 25  ? 5.41369   10.67340  -4.13588  1.000 16.71113 ? 61  PHE A CE2 1 
ATOM   142  C  CZ  . PHE A 1 25  ? 5.54869   12.07589  -4.18937  1.000 17.44798 ? 61  PHE A CZ  1 
ATOM   143  N  N   . GLN A 1 26  ? 0.76678   10.35990  -3.69258  1.000 16.71878 ? 62  GLN A N   1 
ATOM   144  C  CA  . GLN A 1 26  ? 0.45578   9.93089   -5.06944  1.000 20.74741 ? 62  GLN A CA  1 
ATOM   145  C  C   . GLN A 1 26  ? -0.12378  8.51074   -5.14754  1.000 21.80666 ? 62  GLN A C   1 
ATOM   146  O  O   . GLN A 1 26  ? 0.41183   7.64818   -5.83657  1.000 24.04088 ? 62  GLN A O   1 
ATOM   147  C  CB  . GLN A 1 26  ? 1.69712   10.04064  -5.98435  1.000 19.59188 ? 62  GLN A CB  1 
ATOM   148  C  CG  . GLN A 1 26  ? 2.32671   11.45492  -5.99431  1.000 22.70789 ? 62  GLN A CG  1 
ATOM   149  C  CD  . GLN A 1 26  ? 3.25789   11.71162  -7.19357  1.000 27.47780 ? 62  GLN A CD  1 
ATOM   150  O  OE1 . GLN A 1 26  ? 4.10895   10.86665  -7.53401  1.000 23.37114 ? 62  GLN A OE1 1 
ATOM   151  N  NE2 . GLN A 1 26  ? 3.14033   12.90677  -7.79673  1.000 29.01079 ? 62  GLN A NE2 1 
ATOM   152  N  N   . LYS A 1 27  ? -1.28418  8.29993   -4.53663  1.000 19.10927 ? 63  LYS A N   1 
ATOM   153  C  CA  . LYS A 1 27  ? -2.01147  7.03101   -4.73015  1.000 22.29330 ? 63  LYS A CA  1 
ATOM   154  C  C   . LYS A 1 27  ? -1.36216  5.83221   -4.05624  1.000 19.31838 ? 63  LYS A C   1 
ATOM   155  O  O   . LYS A 1 27  ? -1.89149  4.72434   -4.18940  1.000 21.86249 ? 63  LYS A O   1 
ATOM   156  C  CB  . LYS A 1 27  ? -2.27226  6.67588   -6.21784  1.000 26.02627 ? 63  LYS A CB  1 
ATOM   157  C  CG  . LYS A 1 27  ? -2.52924  7.89894   -7.10051  1.000 30.63474 ? 63  LYS A CG  1 
ATOM   158  C  CD  . LYS A 1 27  ? -3.20628  7.61603   -8.40159  1.000 37.25497 ? 63  LYS A CD  1 
ATOM   159  C  CE  . LYS A 1 27  ? -2.19455  7.01039   -9.36399  1.000 42.54180 ? 63  LYS A CE  1 
ATOM   160  N  NZ  . LYS A 1 27  ? -2.71132  6.99161   -10.77182 1.000 46.18714 ? 63  LYS A NZ  1 
ATOM   161  N  N   . SER A 1 28  ? -0.30909  6.02259   -3.24869  1.000 16.07451 ? 64  SER A N   1 
ATOM   162  C  CA  . SER A 1 28  ? 0.10179   4.97002   -2.32241  1.000 15.00362 ? 64  SER A CA  1 
ATOM   163  C  C   . SER A 1 28  ? -0.00823  5.45198   -0.87997  1.000 13.92739 ? 64  SER A C   1 
ATOM   164  O  O   . SER A 1 28  ? 0.09780   6.64138   -0.60922  1.000 14.55843 ? 64  SER A O   1 
ATOM   165  C  CB  . SER A 1 28  ? 1.58162   4.56251   -2.54315  1.000 14.27541 ? 64  SER A CB  1 
ATOM   166  O  OG  . SER A 1 28  ? 1.65094   3.76772   -3.74967  1.000 14.80032 ? 64  SER A OG  1 
ATOM   167  N  N   . LEU A 1 29  ? -0.07142  4.48287   0.01552   1.000 13.50986 ? 65  LEU A N   1 
ATOM   168  C  CA  . LEU A 1 29  ? 0.17721   4.70226   1.43373   1.000 14.17987 ? 65  LEU A CA  1 
ATOM   169  C  C   . LEU A 1 29  ? 1.54463   4.15701   1.79072   1.000 14.84472 ? 65  LEU A C   1 
ATOM   170  O  O   . LEU A 1 29  ? 1.99296   3.13407   1.25267   1.000 15.23045 ? 65  LEU A O   1 
ATOM   171  C  CB  . LEU A 1 29  ? -0.89608  4.00264   2.26960   1.000 15.08533 ? 65  LEU A CB  1 
ATOM   172  C  CG  . LEU A 1 29  ? -2.30292  4.65032   2.18114   1.000 17.94585 ? 65  LEU A CG  1 
ATOM   173  C  CD1 . LEU A 1 29  ? -3.36212  3.70692   2.73455   1.000 19.75423 ? 65  LEU A CD1 1 
ATOM   174  C  CD2 . LEU A 1 29  ? -2.31749  5.96584   3.03036   1.000 16.15326 ? 65  LEU A CD2 1 
ATOM   175  N  N   . TYR A 1 30  ? 2.18321   4.81913   2.76282   1.000 15.75153 ? 66  TYR A N   1 
ATOM   176  C  CA  . TYR A 1 30  ? 3.55196   4.54698   3.17338   1.000 13.08448 ? 66  TYR A CA  1 
ATOM   177  C  C   . TYR A 1 30  ? 3.56670   4.44503   4.68164   1.000 14.63907 ? 66  TYR A C   1 
ATOM   178  O  O   . TYR A 1 30  ? 2.75583   5.09447   5.35353   1.000 15.08171 ? 66  TYR A O   1 
ATOM   179  C  CB  . TYR A 1 30  ? 4.52690   5.65951   2.72020   1.000 13.33493 ? 66  TYR A CB  1 
ATOM   180  C  CG  . TYR A 1 30  ? 4.62092   5.76378   1.21777   1.000 12.87207 ? 66  TYR A CG  1 
ATOM   181  C  CD1 . TYR A 1 30  ? 3.72942   6.54141   0.50449   1.000 14.12072 ? 66  TYR A CD1 1 
ATOM   182  C  CD2 . TYR A 1 30  ? 5.53960   5.02338   0.51946   1.000 12.23823 ? 66  TYR A CD2 1 
ATOM   183  C  CE1 . TYR A 1 30  ? 3.82987   6.69335   -0.88804  1.000 13.14766 ? 66  TYR A CE1 1 
ATOM   184  C  CE2 . TYR A 1 30  ? 5.68474   5.14986   -0.87642  1.000 11.85311 ? 66  TYR A CE2 1 
ATOM   185  C  CZ  . TYR A 1 30  ? 4.77788   5.95117   -1.57309  1.000 12.85030 ? 66  TYR A CZ  1 
ATOM   186  O  OH  . TYR A 1 30  ? 4.87663   6.13154   -2.91836  1.000 12.27311 ? 66  TYR A OH  1 
ATOM   187  N  N   . TYR A 1 31  ? 4.45396   3.57942   5.21059   1.000 13.71842 ? 67  TYR A N   1 
ATOM   188  C  CA  . TYR A 1 31  ? 4.63828   3.36020   6.64530   1.000 15.46667 ? 67  TYR A CA  1 
ATOM   189  C  C   . TYR A 1 31  ? 6.13385   3.36969   6.92407   1.000 16.90212 ? 67  TYR A C   1 
ATOM   190  O  O   . TYR A 1 31  ? 6.88212   2.60622   6.30031   1.000 15.02342 ? 67  TYR A O   1 
ATOM   191  C  CB  . TYR A 1 31  ? 4.07795   1.98419   7.09008   1.000 19.09420 ? 67  TYR A CB  1 
ATOM   192  C  CG  . TYR A 1 31  ? 4.04162   1.78800   8.60795   1.000 18.60463 ? 67  TYR A CG  1 
ATOM   193  C  CD1 . TYR A 1 31  ? 2.94669   2.24633   9.34324   1.000 21.21235 ? 67  TYR A CD1 1 
ATOM   194  C  CD2 . TYR A 1 31  ? 5.04716   1.10665   9.27400   1.000 18.28668 ? 67  TYR A CD2 1 
ATOM   195  C  CE1 . TYR A 1 31  ? 2.87040   2.06403   10.75429  1.000 24.78718 ? 67  TYR A CE1 1 
ATOM   196  C  CE2 . TYR A 1 31  ? 4.99547   0.91985   10.69595  1.000 20.90654 ? 67  TYR A CE2 1 
ATOM   197  C  CZ  . TYR A 1 31  ? 3.90647   1.41797   11.41569  1.000 23.00954 ? 67  TYR A CZ  1 
ATOM   198  O  OH  . TYR A 1 31  ? 3.82589   1.23361   12.81075  1.000 26.73039 ? 67  TYR A OH  1 
ATOM   199  N  N   . ILE A 1 32  ? 6.57824   4.20474   7.86048   1.000 14.07570 ? 68  ILE A N   1 
ATOM   200  C  CA  . ILE A 1 32  ? 7.98367   4.18670   8.28354   1.000 14.91486 ? 68  ILE A CA  1 
ATOM   201  C  C   . ILE A 1 32  ? 8.04384   3.45946   9.61950   1.000 15.72755 ? 68  ILE A C   1 
ATOM   202  O  O   . ILE A 1 32  ? 7.28160   3.80665   10.54138  1.000 15.18358 ? 68  ILE A O   1 
ATOM   203  C  CB  . ILE A 1 32  ? 8.53906   5.62507   8.40714   1.000 14.74043 ? 68  ILE A CB  1 
ATOM   204  C  CG1 . ILE A 1 32  ? 8.59590   6.25065   7.00566   1.000 13.16173 ? 68  ILE A CG1 1 
ATOM   205  C  CG2 . ILE A 1 32  ? 9.94894   5.64998   9.09388   1.000 15.59317 ? 68  ILE A CG2 1 
ATOM   206  C  CD1 . ILE A 1 32  ? 8.97547   7.75607   6.98654   1.000 13.59973 ? 68  ILE A CD1 1 
ATOM   207  N  N   . SER A 1 33  ? 8.94566   2.44610   9.73502   1.000 12.96327 ? 69  SER A N   1 
ATOM   208  C  CA  . SER A 1 33  ? 8.99620   1.65175   10.95676  1.000 14.80629 ? 69  SER A CA  1 
ATOM   209  C  C   . SER A 1 33  ? 9.51218   2.47783   12.14892  1.000 18.61136 ? 69  SER A C   1 
ATOM   210  O  O   . SER A 1 33  ? 10.21545  3.47389   12.00294  1.000 16.52722 ? 69  SER A O   1 
ATOM   211  C  CB  . SER A 1 33  ? 9.94827   0.46912   10.79494  1.000 14.15274 ? 69  SER A CB  1 
ATOM   212  O  OG  . SER A 1 33  ? 11.23404  1.00875   10.54890  1.000 15.30536 ? 69  SER A OG  1 
ATOM   213  N  N   . SER A 1 34  ? 9.18014   2.01467   13.35079  1.000 20.05301 ? 70  SER A N   1 
ATOM   214  C  CA  . SER A 1 34  ? 9.78802   2.57603   14.55036  1.000 21.85144 ? 70  SER A CA  1 
ATOM   215  C  C   . SER A 1 34  ? 10.90939  1.71093   15.12802  1.000 22.71278 ? 70  SER A C   1 
ATOM   216  O  O   . SER A 1 34  ? 11.48003  2.06641   16.16181  1.000 24.40731 ? 70  SER A O   1 
ATOM   217  C  CB  . SER A 1 34  ? 8.68555   2.91036   15.58673  1.000 26.70855 ? 70  SER A CB  1 
ATOM   218  O  OG  . SER A 1 34  ? 7.70123   1.90029   15.72830  1.000 33.00074 ? 70  SER A OG  1 
ATOM   219  N  N   . VAL A 1 35  ? 11.31933  0.65108   14.42297  1.000 17.94145 ? 71  VAL A N   1 
ATOM   220  C  CA  . VAL A 1 35  ? 12.45555  -0.16503  14.83264  1.000 15.92043 ? 71  VAL A CA  1 
ATOM   221  C  C   . VAL A 1 35  ? 13.27790  -0.43655  13.58913  1.000 14.52161 ? 71  VAL A C   1 
ATOM   222  O  O   . VAL A 1 35  ? 12.76200  -0.38120  12.47186  1.000 17.15119 ? 71  VAL A O   1 
ATOM   223  C  CB  . VAL A 1 35  ? 12.01309  -1.52041  15.41659  1.000 16.70599 ? 71  VAL A CB  1 
ATOM   224  C  CG1 . VAL A 1 35  ? 11.20844  -1.27609  16.72872  1.000 18.96134 ? 71  VAL A CG1 1 
ATOM   225  C  CG2 . VAL A 1 35  ? 11.13826  -2.26891  14.35391  1.000 15.88533 ? 71  VAL A CG2 1 
ATOM   226  N  N   . LYS A 1 36  ? 14.52822  -0.80993  13.80502  1.000 13.99216 ? 72  LYS A N   1 
ATOM   227  C  CA  . LYS A 1 36  ? 15.35435  -1.29064  12.70066  1.000 11.64630 ? 72  LYS A CA  1 
ATOM   228  C  C   . LYS A 1 36  ? 15.19786  -2.78649  12.58606  1.000 15.06848 ? 72  LYS A C   1 
ATOM   229  O  O   . LYS A 1 36  ? 14.88094  -3.46046  13.56950  1.000 15.27749 ? 72  LYS A O   1 
ATOM   230  C  CB  . LYS A 1 36  ? 16.82424  -0.93554  12.97417  1.000 12.17974 ? 72  LYS A CB  1 
ATOM   231  C  CG  . LYS A 1 36  ? 17.04732  0.61369   13.14992  1.000 13.61350 ? 72  LYS A CG  1 
ATOM   232  C  CD  . LYS A 1 36  ? 18.51996  0.98116   13.06235  1.000 15.51452 ? 72  LYS A CD  1 
ATOM   233  C  CE  . LYS A 1 36  ? 18.72782  2.51876   12.98056  1.000 20.63505 ? 72  LYS A CE  1 
ATOM   234  N  NZ  . LYS A 1 36  ? 20.21107  2.78562   12.84031  1.000 19.90848 ? 72  LYS A NZ  1 
ATOM   235  N  N   . ASN A 1 37  ? 15.49753  -3.31584  11.40590  1.000 14.32956 ? 73  ASN A N   1 
ATOM   236  C  CA  . ASN A 1 37  ? 15.53165  -4.77106  11.27637  1.000 12.13208 ? 73  ASN A CA  1 
ATOM   237  C  C   . ASN A 1 37  ? 16.32412  -5.18854  10.03748  1.000 13.43121 ? 73  ASN A C   1 
ATOM   238  O  O   . ASN A 1 37  ? 16.74984  -4.35746  9.21674   1.000 12.66200 ? 73  ASN A O   1 
ATOM   239  C  CB  . ASN A 1 37  ? 14.11360  -5.33071  11.19778  1.000 14.04621 ? 73  ASN A CB  1 
ATOM   240  C  CG  . ASN A 1 37  ? 13.95133  -6.54829  12.05633  1.000 15.46550 ? 73  ASN A CG  1 
ATOM   241  O  OD1 . ASN A 1 37  ? 14.87551  -7.32577  12.17402  1.000 14.79600 ? 73  ASN A OD1 1 
ATOM   242  N  ND2 . ASN A 1 37  ? 12.76780  -6.73997  12.62537  1.000 14.01751 ? 73  ASN A ND2 1 
ATOM   243  N  N   . THR A 1 38  ? 16.55971  -6.50688  9.94055   1.000 14.98457 ? 74  THR A N   1 
ATOM   244  C  CA  . THR A 1 38  ? 17.21504  -7.02924  8.72569   1.000 14.15810 ? 74  THR A CA  1 
ATOM   245  C  C   . THR A 1 38  ? 16.29407  -6.79210  7.55208   1.000 15.10071 ? 74  THR A C   1 
ATOM   246  O  O   . THR A 1 38  ? 15.11783  -6.54718  7.72192   1.000 12.63746 ? 74  THR A O   1 
ATOM   247  C  CB  . THR A 1 38  ? 17.48899  -8.51516  8.84442   1.000 17.68332 ? 74  THR A CB  1 
ATOM   248  O  OG1 . THR A 1 38  ? 16.22907  -9.20879  8.94484   1.000 15.90998 ? 74  THR A OG1 1 
ATOM   249  C  CG2 . THR A 1 38  ? 18.37316  -8.76515  10.11622  1.000 14.28893 ? 74  THR A CG2 1 
ATOM   250  N  N   . TRP A 1 39  ? 16.82863  -6.94145  6.34372   1.000 14.12642 ? 75  TRP A N   1 
ATOM   251  C  CA  . TRP A 1 39  ? 16.00851  -6.61760  5.18850   1.000 11.56018 ? 75  TRP A CA  1 
ATOM   252  C  C   . TRP A 1 39  ? 14.83850  -7.57998  5.10202   1.000 16.11371 ? 75  TRP A C   1 
ATOM   253  O  O   . TRP A 1 39  ? 13.68025  -7.18448  4.88841   1.000 12.04068 ? 75  TRP A O   1 
ATOM   254  C  CB  . TRP A 1 39  ? 16.87725  -6.66530  3.91955   1.000 11.07336 ? 75  TRP A CB  1 
ATOM   255  C  CG  . TRP A 1 39  ? 16.15300  -6.25678  2.63047   1.000 12.23101 ? 75  TRP A CG  1 
ATOM   256  C  CD1 . TRP A 1 39  ? 16.14830  -4.98030  2.02482   1.000 10.59539 ? 75  TRP A CD1 1 
ATOM   257  C  CD2 . TRP A 1 39  ? 15.37043  -7.11414  1.79924   1.000 12.13032 ? 75  TRP A CD2 1 
ATOM   258  N  NE1 . TRP A 1 39  ? 15.41125  -5.05215  0.86414   1.000 13.50876 ? 75  TRP A NE1 1 
ATOM   259  C  CE2 . TRP A 1 39  ? 14.92493  -6.33872  0.70468   1.000 14.13273 ? 75  TRP A CE2 1 
ATOM   260  C  CE3 . TRP A 1 39  ? 15.01746  -8.48838  1.86676   1.000 14.25386 ? 75  TRP A CE3 1 
ATOM   261  C  CZ2 . TRP A 1 39  ? 14.09980  -6.85146  -0.28880  1.000 12.29996 ? 75  TRP A CZ2 1 
ATOM   262  C  CZ3 . TRP A 1 39  ? 14.19410  -9.00085  0.85842   1.000 15.28102 ? 75  TRP A CZ3 1 
ATOM   263  C  CH2 . TRP A 1 39  ? 13.77440  -8.17282  -0.21578  1.000 14.07338 ? 75  TRP A CH2 1 
ATOM   264  N  N   . HIS A 1 40  ? 15.12259  -8.84380  5.36126   1.000 13.84742 ? 76  HIS A N   1 
ATOM   265  C  CA  . HIS A 1 40  ? 14.09611  -9.87467  5.30378   1.000 15.33738 ? 76  HIS A CA  1 
ATOM   266  C  C   . HIS A 1 40  ? 13.02485  -9.70815  6.38058   1.000 13.28982 ? 76  HIS A C   1 
ATOM   267  O  O   . HIS A 1 40  ? 11.83597  -9.85982  6.08763   1.000 14.60793 ? 76  HIS A O   1 
ATOM   268  C  CB  . HIS A 1 40  ? 14.79493  -11.24051 5.42519   1.000 16.04516 ? 76  HIS A CB  1 
ATOM   269  C  CG  . HIS A 1 40  ? 15.57504  -11.56644 4.18302   1.000 18.44120 ? 76  HIS A CG  1 
ATOM   270  N  ND1 . HIS A 1 40  ? 16.93832  -11.39635 4.07782   1.000 24.51778 ? 76  HIS A ND1 1 
ATOM   271  C  CD2 . HIS A 1 40  ? 15.14277  -11.95943 2.96379   1.000 21.97111 ? 76  HIS A CD2 1 
ATOM   272  C  CE1 . HIS A 1 40  ? 17.32567  -11.70784 2.85211   1.000 26.01722 ? 76  HIS A CE1 1 
ATOM   273  N  NE2 . HIS A 1 40  ? 16.25215  -12.05852 2.15304   1.000 24.83063 ? 76  HIS A NE2 1 
ATOM   274  N  N   . LEU A 1 41  ? 13.39962  -9.40676  7.61033   1.000 13.68524 ? 77  LEU A N   1 
ATOM   275  C  CA  . LEU A 1 41  ? 12.34246  -9.22528  8.61544   1.000 13.24908 ? 77  LEU A CA  1 
ATOM   276  C  C   . LEU A 1 41  ? 11.61023  -7.87985  8.44204   1.000 14.48609 ? 77  LEU A C   1 
ATOM   277  O  O   . LEU A 1 41  ? 10.41674  -7.75365  8.82848   1.000 11.47935 ? 77  LEU A O   1 
ATOM   278  C  CB  . LEU A 1 41  ? 12.94002  -9.33741  10.02614  1.000 14.37429 ? 77  LEU A CB  1 
ATOM   279  C  CG  . LEU A 1 41  ? 13.28169  -10.76594 10.49462  1.000 17.46334 ? 77  LEU A CG  1 
ATOM   280  C  CD1 . LEU A 1 41  ? 13.95410  -10.79713 11.91005  1.000 17.52308 ? 77  LEU A CD1 1 
ATOM   281  C  CD2 . LEU A 1 41  ? 12.03037  -11.63413 10.58232  1.000 18.80670 ? 77  LEU A CD2 1 
ATOM   282  N  N   . SER A 1 42  ? 12.29023  -6.88551  7.87494   1.000 13.03762 ? 78  SER A N   1 
ATOM   283  C  CA  . SER A 1 42  ? 11.58462  -5.65792  7.51272   1.000 14.64096 ? 78  SER A CA  1 
ATOM   284  C  C   . SER A 1 42  ? 10.49415  -5.98284  6.52800   1.000 13.65672 ? 78  SER A C   1 
ATOM   285  O  O   . SER A 1 42  ? 9.34970   -5.54792  6.66732   1.000 13.79539 ? 78  SER A O   1 
ATOM   286  C  CB  . SER A 1 42  ? 12.53957  -4.63129  6.86602   1.000 13.32993 ? 78  SER A CB  1 
ATOM   287  O  OG  . SER A 1 42  ? 13.58784  -4.31574  7.79378   1.000 13.46030 ? 78  SER A OG  1 
ATOM   288  N  N   . ARG A 1 43  ? 10.87216  -6.66106  5.45533   1.000 13.10551 ? 79  ARG A N   1 
ATOM   289  C  CA  . ARG A 1 43  ? 9.88552   -7.05967  4.45858   1.000 13.46031 ? 79  ARG A CA  1 
ATOM   290  C  C   . ARG A 1 43  ? 8.74345   -7.86285  5.08422   1.000 15.76872 ? 79  ARG A C   1 
ATOM   291  O  O   . ARG A 1 43  ? 7.57830   -7.65509  4.73218   1.000 13.85518 ? 79  ARG A O   1 
ATOM   292  C  CB  . ARG A 1 43  ? 10.56644  -7.89889  3.36017   1.000 12.39001 ? 79  ARG A CB  1 
ATOM   293  C  CG  . ARG A 1 43  ? 9.52842   -8.09267  2.20850   1.000 14.69524 ? 79  ARG A CG  1 
ATOM   294  C  CD  . ARG A 1 43  ? 10.01292  -8.96623  1.05740   1.000 14.59267 ? 79  ARG A CD  1 
ATOM   295  N  NE  . ARG A 1 43  ? 8.99335   -8.94877  -0.01386  1.000 13.46286 ? 79  ARG A NE  1 
ATOM   296  C  CZ  . ARG A 1 43  ? 8.79177   -9.97971  -0.82299  1.000 17.15764 ? 79  ARG A CZ  1 
ATOM   297  N  NH1 . ARG A 1 43  ? 9.48883   -11.09751 -0.68715  1.000 18.02206 ? 79  ARG A NH1 1 
ATOM   298  N  NH2 . ARG A 1 43  ? 7.84563   -9.90251  -1.76119  1.000 13.95051 ? 79  ARG A NH2 1 
ATOM   299  N  N   . GLU A 1 44  ? 9.06047   -8.84212  5.94514   1.000 15.08271 ? 80  GLU A N   1 
ATOM   300  C  CA  . GLU A 1 44  ? 7.99836   -9.63077  6.59512   1.000 16.29817 ? 80  GLU A CA  1 
ATOM   301  C  C   . GLU A 1 44  ? 6.98505   -8.75319  7.32596   1.000 16.48409 ? 80  GLU A C   1 
ATOM   302  O  O   . GLU A 1 44  ? 5.79051   -9.06810  7.32752   1.000 15.24217 ? 80  GLU A O   1 
ATOM   303  C  CB  . GLU A 1 44  ? 8.59494   -10.62702 7.59130   1.000 17.38396 ? 80  GLU A CB  1 
ATOM   304  C  CG  . GLU A 1 44  ? 9.14779   -11.84417 6.89237   1.000 19.07912 ? 80  GLU A CG  1 
ATOM   305  C  CD  . GLU A 1 44  ? 9.44908   -12.95730 7.85712   1.000 25.67573 ? 80  GLU A CD  1 
ATOM   306  O  OE1 . GLU A 1 44  ? 8.96628   -12.94140 9.04299   1.000 26.53712 ? 80  GLU A OE1 1 
ATOM   307  O  OE2 . GLU A 1 44  ? 10.17668  -13.84096 7.37984   1.000 25.45858 ? 80  GLU A OE2 1 
ATOM   308  N  N   . TYR A 1 45  ? 7.44000   -7.68674  8.00494   1.000 14.49583 ? 81  TYR A N   1 
ATOM   309  C  CA  . TYR A 1 45  ? 6.46339   -6.78997  8.64100   1.000 13.90720 ? 81  TYR A CA  1 
ATOM   310  C  C   . TYR A 1 45  ? 5.53066   -6.19288  7.58041   1.000 14.87429 ? 81  TYR A C   1 
ATOM   311  O  O   . TYR A 1 45  ? 4.29240   -6.19428  7.73189   1.000 15.43255 ? 81  TYR A O   1 
ATOM   312  C  CB  . TYR A 1 45  ? 7.18244   -5.67533  9.45553   1.000 15.81453 ? 81  TYR A CB  1 
ATOM   313  C  CG  . TYR A 1 45  ? 6.18072   -4.66918  10.04625  1.000 15.27676 ? 81  TYR A CG  1 
ATOM   314  C  CD1 . TYR A 1 45  ? 5.74399   -3.56308  9.28242   1.000 12.29966 ? 81  TYR A CD1 1 
ATOM   315  C  CD2 . TYR A 1 45  ? 5.64870   -4.86258  11.32529  1.000 15.41910 ? 81  TYR A CD2 1 
ATOM   316  C  CE1 . TYR A 1 45  ? 4.75717   -2.68532  9.79038   1.000 15.37015 ? 81  TYR A CE1 1 
ATOM   317  C  CE2 . TYR A 1 45  ? 4.68355   -3.98790  11.84861  1.000 15.56138 ? 81  TYR A CE2 1 
ATOM   318  C  CZ  . TYR A 1 45  ? 4.26242   -2.90848  11.08709  1.000 17.03283 ? 81  TYR A CZ  1 
ATOM   319  O  OH  . TYR A 1 45  ? 3.33324   -2.08172  11.63596  1.000 17.98481 ? 81  TYR A OH  1 
ATOM   320  N  N   . CYS A 1 46  ? 6.10413   -5.73116  6.46338   1.000 15.00835 ? 82  CYS A N   1 
ATOM   321  C  CA  . CYS A 1 46  ? 5.26513   -5.07074  5.46146   1.000 12.36237 ? 82  CYS A CA  1 
ATOM   322  C  C   . CYS A 1 46  ? 4.29352   -6.06295  4.85432   1.000 14.94495 ? 82  CYS A C   1 
ATOM   323  O  O   . CYS A 1 46  ? 3.13786   -5.72415  4.55798   1.000 14.34617 ? 82  CYS A O   1 
ATOM   324  C  CB  . CYS A 1 46  ? 6.13509   -4.49397  4.33943   1.000 12.78132 ? 82  CYS A CB  1 
ATOM   325  S  SG  . CYS A 1 46  ? 7.30461   -3.14210  4.89595   1.000 15.78381 ? 82  CYS A SG  1 
ATOM   326  N  N   . LEU A 1 47  ? 4.77333   -7.28294  4.62093   1.000 13.58480 ? 83  LEU A N   1 
ATOM   327  C  CA  . LEU A 1 47  ? 3.89274   -8.31628  4.06822   1.000 14.33127 ? 83  LEU A CA  1 
ATOM   328  C  C   . LEU A 1 47  ? 2.71751   -8.57322  5.00410   1.000 14.96688 ? 83  LEU A C   1 
ATOM   329  O  O   . LEU A 1 47  ? 1.58917   -8.76237  4.54730   1.000 15.16953 ? 83  LEU A O   1 
ATOM   330  C  CB  . LEU A 1 47  ? 4.68498   -9.59744  3.84003   1.000 15.53843 ? 83  LEU A CB  1 
ATOM   331  C  CG  . LEU A 1 47  ? 5.84605   -9.56996  2.82524   1.000 14.95173 ? 83  LEU A CG  1 
ATOM   332  C  CD1 . LEU A 1 47  ? 6.48706   -10.94217 2.85504   1.000 17.59416 ? 83  LEU A CD1 1 
ATOM   333  C  CD2 . LEU A 1 47  ? 5.28579   -9.28706  1.39038   1.000 15.65813 ? 83  LEU A CD2 1 
ATOM   334  N  N   . GLN A 1 48  ? 2.98075   -8.60670  6.31184   1.000 16.31696 ? 84  GLN A N   1 
ATOM   335  C  CA  . GLN A 1 48  ? 1.93382   -8.87571  7.30180   1.000 21.24462 ? 84  GLN A CA  1 
ATOM   336  C  C   . GLN A 1 48  ? 0.86719   -7.80823  7.30724   1.000 21.63778 ? 84  GLN A C   1 
ATOM   337  O  O   . GLN A 1 48  ? -0.28767  -8.09064  7.66770   1.000 21.15317 ? 84  GLN A O   1 
ATOM   338  C  CB  . GLN A 1 48  ? 2.50529   -9.00831  8.70920   1.000 23.14537 ? 84  GLN A CB  1 
ATOM   339  C  CG  . GLN A 1 48  ? 3.27791   -10.31276 8.89599   1.000 48.85119 ? 84  GLN A CG  1 
ATOM   340  C  CD  . GLN A 1 48  ? 4.26721   -10.29034 10.05153  1.000 63.71778 ? 84  GLN A CD  1 
ATOM   341  O  OE1 . GLN A 1 48  ? 4.58132   -9.23380  10.63218  1.000 52.20429 ? 84  GLN A OE1 1 
ATOM   342  N  NE2 . GLN A 1 48  ? 4.81198   -11.46191 10.35587  1.000 44.22723 ? 84  GLN A NE2 1 
ATOM   343  N  N   . GLU A 1 49  ? 1.22372   -6.59348  6.91857   1.000 17.65433 ? 85  GLU A N   1 
ATOM   344  C  CA  . GLU A 1 49  ? 0.30322   -5.48192  6.77179   1.000 18.04668 ? 85  GLU A CA  1 
ATOM   345  C  C   . GLU A 1 49  ? -0.40657  -5.44566  5.41347   1.000 18.57027 ? 85  GLU A C   1 
ATOM   346  O  O   . GLU A 1 49  ? -1.11086  -4.45280  5.11696   1.000 18.46852 ? 85  GLU A O   1 
ATOM   347  C  CB  . GLU A 1 49  ? 1.05495   -4.16250  6.97294   1.000 19.39896 ? 85  GLU A CB  1 
ATOM   348  C  CG  . GLU A 1 49  ? 1.64699   -4.07027  8.36960   1.000 18.58744 ? 85  GLU A CG  1 
ATOM   349  C  CD  . GLU A 1 49  ? 0.53691   -4.02576  9.43824   1.000 22.30984 ? 85  GLU A CD  1 
ATOM   350  O  OE1 . GLU A 1 49  ? -0.43305  -3.26438  9.25280   1.000 29.23083 ? 85  GLU A OE1 1 
ATOM   351  O  OE2 . GLU A 1 49  ? 0.62001   -4.76886  10.41379  1.000 29.28671 ? 85  GLU A OE2 1 
ATOM   352  N  N   . GLY A 1 50  ? -0.27993  -6.50396  4.61402   1.000 16.57319 ? 86  GLY A N   1 
ATOM   353  C  CA  . GLY A 1 50  ? -0.87289  -6.46508  3.28395   1.000 18.52232 ? 86  GLY A CA  1 
ATOM   354  C  C   . GLY A 1 50  ? -0.16340  -5.49911  2.36111   1.000 17.45922 ? 86  GLY A C   1 
ATOM   355  O  O   . GLY A 1 50  ? -0.80660  -4.87841  1.49009   1.000 15.79561 ? 86  GLY A O   1 
ATOM   356  N  N   . ALA A 1 51  ? 1.15927   -5.41811  2.47327   1.000 14.62032 ? 87  ALA A N   1 
ATOM   357  C  CA  . ALA A 1 51  ? 1.90768   -4.45186  1.69480   1.000 13.26168 ? 87  ALA A CA  1 
ATOM   358  C  C   . ALA A 1 51  ? 3.23339   -5.09360  1.28852   1.000 14.03354 ? 87  ALA A C   1 
ATOM   359  O  O   . ALA A 1 51  ? 3.35551   -6.32150  1.14248   1.000 13.55582 ? 87  ALA A O   1 
ATOM   360  C  CB  . ALA A 1 51  ? 2.12060   -3.17254  2.53962   1.000 13.67133 ? 87  ALA A CB  1 
ATOM   361  N  N   . ASP A 1 52  ? 4.23737   -4.24921  1.07004   1.000 12.32809 ? 88  ASP A N   1 
ATOM   362  C  CA  . ASP A 1 52  ? 5.58729   -4.74482  0.80465   1.000 11.94285 ? 88  ASP A CA  1 
ATOM   363  C  C   . ASP A 1 52  ? 6.51858   -3.58136  1.08309   1.000 12.17978 ? 88  ASP A C   1 
ATOM   364  O  O   . ASP A 1 52  ? 6.06831   -2.45667  1.28001   1.000 13.62554 ? 88  ASP A O   1 
ATOM   365  C  CB  . ASP A 1 52  ? 5.77247   -5.18509  -0.65519  1.000 12.74672 ? 88  ASP A CB  1 
ATOM   366  C  CG  . ASP A 1 52  ? 6.64359   -6.43677  -0.78299  1.000 14.90772 ? 88  ASP A CG  1 
ATOM   367  O  OD1 . ASP A 1 52  ? 7.63023   -6.50291  -0.02818  1.000 14.07349 ? 88  ASP A OD1 1 
ATOM   368  O  OD2 . ASP A 1 52  ? 6.34864   -7.32245  -1.61603  1.000 14.91513 ? 88  ASP A OD2 1 
ATOM   369  N  N   . LEU A 1 53  ? 7.79996   -3.84903  0.98763   1.000 12.37800 ? 89  LEU A N   1 
ATOM   370  C  CA  . LEU A 1 53  ? 8.76838   -2.75908  1.02378   1.000 10.75151 ? 89  LEU A CA  1 
ATOM   371  C  C   . LEU A 1 53  ? 8.56765   -1.82946  -0.16911  1.000 12.54001 ? 89  LEU A C   1 
ATOM   372  O  O   . LEU A 1 53  ? 8.01703   -2.21180  -1.19852  1.000 12.85783 ? 89  LEU A O   1 
ATOM   373  C  CB  . LEU A 1 53  ? 10.19084  -3.33744  0.98603   1.000 11.86788 ? 89  LEU A CB  1 
ATOM   374  C  CG  . LEU A 1 53  ? 10.62589  -3.95854  2.34331   1.000 11.56963 ? 89  LEU A CG  1 
ATOM   375  C  CD1 . LEU A 1 53  ? 11.95666  -4.66494  2.06331   1.000 12.53171 ? 89  LEU A CD1 1 
ATOM   376  C  CD2 . LEU A 1 53  ? 10.81345  -2.90061  3.47006   1.000 11.61544 ? 89  LEU A CD2 1 
ATOM   377  N  N   . ALA A 1 54  ? 8.97214   -0.58535  -0.01035  1.000 13.07885 ? 90  ALA A N   1 
ATOM   378  C  CA  . ALA A 1 54  ? 8.63694   0.43346   -1.00138  1.000 13.46741 ? 90  ALA A CA  1 
ATOM   379  C  C   . ALA A 1 54  ? 9.34374   0.17318   -2.34515  1.000 12.28620 ? 90  ALA A C   1 
ATOM   380  O  O   . ALA A 1 54  ? 10.48161  -0.30197  -2.39858  1.000 13.10785 ? 90  ALA A O   1 
ATOM   381  C  CB  . ALA A 1 54  ? 9.01309   1.81158   -0.45864  1.000 12.86367 ? 90  ALA A CB  1 
ATOM   382  N  N   . ILE A 1 55  ? 8.61929   0.43709   -3.43300  1.000 11.16797 ? 91  ILE A N   1 
ATOM   383  C  CA  . ILE A 1 55  ? 9.11453   0.25833   -4.80860  1.000 12.48017 ? 91  ILE A CA  1 
ATOM   384  C  C   . ILE A 1 55  ? 9.18572   1.66409   -5.42661  1.000 10.58347 ? 91  ILE A C   1 
ATOM   385  O  O   . ILE A 1 55  ? 8.17432   2.36682   -5.43102  1.000 13.79813 ? 91  ILE A O   1 
ATOM   386  C  CB  . ILE A 1 55  ? 8.13968   -0.61409  -5.62414  1.000 11.61484 ? 91  ILE A CB  1 
ATOM   387  C  CG1 . ILE A 1 55  ? 8.10547   -2.02979  -5.02380  1.000 13.37644 ? 91  ILE A CG1 1 
ATOM   388  C  CG2 . ILE A 1 55  ? 8.60306   -0.55362  -7.14934  1.000 12.10987 ? 91  ILE A CG2 1 
ATOM   389  C  CD1 . ILE A 1 55  ? 6.97266   -2.90109  -5.68116  1.000 13.87484 ? 91  ILE A CD1 1 
ATOM   390  N  N   . ILE A 1 56  ? 10.35115  2.08934   -5.91833  1.000 10.83980 ? 92  ILE A N   1 
ATOM   391  C  CA  . ILE A 1 56  ? 10.49400  3.46812   -6.39659  1.000 14.56679 ? 92  ILE A CA  1 
ATOM   392  C  C   . ILE A 1 56  ? 10.17837  3.49469   -7.89423  1.000 16.55319 ? 92  ILE A C   1 
ATOM   393  O  O   . ILE A 1 56  ? 10.89252  2.87398   -8.69819  1.000 15.15455 ? 92  ILE A O   1 
ATOM   394  C  CB  . ILE A 1 56  ? 11.89773  4.00724   -6.09593  1.000 12.89294 ? 92  ILE A CB  1 
ATOM   395  C  CG1 . ILE A 1 56  ? 12.13219  3.94009   -4.59544  1.000 13.71957 ? 92  ILE A CG1 1 
ATOM   396  C  CG2 . ILE A 1 56  ? 12.03117  5.46203   -6.64448  1.000 15.65364 ? 92  ILE A CG2 1 
ATOM   397  C  CD1 . ILE A 1 56  ? 11.09205  4.65539   -3.69720  1.000 15.74974 ? 92  ILE A CD1 1 
ATOM   398  N  N   . ASN A 1 57  ? 9.08857   4.20085   -8.27848  1.000 14.28452 ? 93  ASN A N   1 
ATOM   399  C  CA  . ASN A 1 57  ? 8.60485   4.14320   -9.66827  1.000 18.18222 ? 93  ASN A CA  1 
ATOM   400  C  C   . ASN A 1 57  ? 8.77119   5.46036   -10.42731 1.000 18.13662 ? 93  ASN A C   1 
ATOM   401  O  O   . ASN A 1 57  ? 8.49680   5.51158   -11.62457 1.000 19.12597 ? 93  ASN A O   1 
ATOM   402  C  CB  . ASN A 1 57  ? 7.13364   3.73983   -9.74418  1.000 19.21387 ? 93  ASN A CB  1 
ATOM   403  C  CG  . ASN A 1 57  ? 6.83756   2.44939   -9.03872  1.000 17.97334 ? 93  ASN A CG  1 
ATOM   404  O  OD1 . ASN A 1 57  ? 6.49632   2.41903   -7.83358  1.000 18.08213 ? 93  ASN A OD1 1 
ATOM   405  N  ND2 . ASN A 1 57  ? 6.99746   1.36846   -9.77593  1.000 18.03230 ? 93  ASN A ND2 1 
ATOM   406  N  N   . SER A 1 58  ? 9.25331   6.49787   -9.78638  1.000 19.01383 ? 94  SER A N   1 
ATOM   407  C  CA  . SER A 1 58  ? 9.39459   7.78455   -10.46873 1.000 20.54031 ? 94  SER A CA  1 
ATOM   408  C  C   . SER A 1 58  ? 10.39385  8.65900   -9.72657  1.000 20.91814 ? 94  SER A C   1 
ATOM   409  O  O   . SER A 1 58  ? 10.71057  8.43070   -8.56275  1.000 16.80290 ? 94  SER A O   1 
ATOM   410  C  CB  . SER A 1 58  ? 8.05801   8.50589   -10.56627 1.000 22.14489 ? 94  SER A CB  1 
ATOM   411  O  OG  . SER A 1 58  ? 7.64098   8.94173   -9.29387  1.000 19.93660 ? 94  SER A OG  1 
ATOM   412  N  N   . ARG A 1 59  ? 10.86974  9.69079   -10.42988 1.000 17.61070 ? 95  ARG A N   1 
ATOM   413  C  CA  . ARG A 1 59  ? 11.80303  10.62412  -9.82112  1.000 18.62323 ? 95  ARG A CA  1 
ATOM   414  C  C   . ARG A 1 59  ? 11.16635  11.29864  -8.62220  1.000 16.01141 ? 95  ARG A C   1 
ATOM   415  O  O   . ARG A 1 59  ? 11.83355  11.55122  -7.62434  1.000 18.76390 ? 95  ARG A O   1 
ATOM   416  C  CB  . ARG A 1 59  ? 12.24077  11.65667  -10.85634 1.000 22.55220 ? 95  ARG A CB  1 
ATOM   417  C  CG  . ARG A 1 59  ? 13.54303  12.36535  -10.45357 1.000 31.85361 ? 95  ARG A CG  1 
ATOM   418  C  CD  . ARG A 1 59  ? 14.02745  13.31936  -11.57682 1.000 41.13653 ? 95  ARG A CD  1 
ATOM   419  N  NE  . ARG A 1 59  ? 14.67533  12.55003  -12.63418 1.000 53.22146 ? 95  ARG A NE  1 
ATOM   420  C  CZ  . ARG A 1 59  ? 15.91284  12.07175  -12.55676 1.000 51.97046 ? 95  ARG A CZ  1 
ATOM   421  N  NH1 . ARG A 1 59  ? 16.67781  12.29885  -11.49392 1.000 47.22107 ? 95  ARG A NH1 1 
ATOM   422  N  NH2 . ARG A 1 59  ? 16.38703  11.33015  -13.55885 1.000 47.33678 ? 95  ARG A NH2 1 
ATOM   423  N  N   . ALA A 1 60  ? 9.88989   11.57664  -8.70198  1.000 19.41634 ? 96  ALA A N   1 
ATOM   424  C  CA  . ALA A 1 60  ? 9.22120   12.25253  -7.59672  1.000 18.96193 ? 96  ALA A CA  1 
ATOM   425  C  C   . ALA A 1 60  ? 9.13476   11.35412  -6.38014  1.000 20.03184 ? 96  ALA A C   1 
ATOM   426  O  O   . ALA A 1 60  ? 9.29552   11.81152  -5.24896  1.000 18.07386 ? 96  ALA A O   1 
ATOM   427  C  CB  . ALA A 1 60  ? 7.80422   12.68226  -7.99064  1.000 22.10928 ? 96  ALA A CB  1 
ATOM   428  N  N   . GLU A 1 61  ? 8.84006   10.07144  -6.59552  1.000 18.08936 ? 97  GLU A N   1 
ATOM   429  C  CA  . GLU A 1 61  ? 8.80114   9.15074   -5.45769  1.000 16.49391 ? 97  GLU A CA  1 
ATOM   430  C  C   . GLU A 1 61  ? 10.19118  9.00872   -4.81592  1.000 16.48047 ? 97  GLU A C   1 
ATOM   431  O  O   . GLU A 1 61  ? 10.32234  8.91186   -3.58931  1.000 15.41104 ? 97  GLU A O   1 
ATOM   432  C  CB  . GLU A 1 61  ? 8.27717   7.80247   -5.97110  1.000 17.22618 ? 97  GLU A CB  1 
ATOM   433  C  CG  . GLU A 1 61  ? 7.88543   6.86995   -4.81039  1.000 13.49542 ? 97  GLU A CG  1 
ATOM   434  C  CD  . GLU A 1 61  ? 7.24792   5.55492   -5.21212  1.000 15.76694 ? 97  GLU A CD  1 
ATOM   435  O  OE1 . GLU A 1 61  ? 7.28093   5.13209   -6.40406  1.000 18.58402 ? 97  GLU A OE1 1 
ATOM   436  O  OE2 . GLU A 1 61  ? 6.67796   4.94740   -4.25384  1.000 14.06578 ? 97  GLU A OE2 1 
ATOM   437  N  N   . GLN A 1 62  ? 11.25012  8.98534   -5.64421  1.000 16.02837 ? 98  GLN A N   1 
ATOM   438  C  CA  . GLN A 1 62  ? 12.61291  9.00218   -5.10582  1.000 15.36911 ? 98  GLN A CA  1 
ATOM   439  C  C   . GLN A 1 62  ? 12.86501  10.26183  -4.27647  1.000 19.00355 ? 98  GLN A C   1 
ATOM   440  O  O   . GLN A 1 62  ? 13.49103  10.20607  -3.20858  1.000 18.27355 ? 98  GLN A O   1 
ATOM   441  C  CB  . GLN A 1 62  ? 13.65342  8.89171   -6.23281  1.000 15.79970 ? 98  GLN A CB  1 
ATOM   442  C  CG  . GLN A 1 62  ? 15.07637  8.97914   -5.69883  1.000 15.30595 ? 98  GLN A CG  1 
ATOM   443  C  CD  . GLN A 1 62  ? 15.47412  7.83647   -4.76326  1.000 15.62155 ? 98  GLN A CD  1 
ATOM   444  O  OE1 . GLN A 1 62  ? 14.88969  6.74487   -4.80256  1.000 15.78326 ? 98  GLN A OE1 1 
ATOM   445  N  NE2 . GLN A 1 62  ? 16.53911  8.05130   -3.97834  1.000 13.59285 ? 98  GLN A NE2 1 
ATOM   446  N  N   . ALA A 1 63  ? 12.42486  11.43125  -4.76655  1.000 16.29731 ? 99  ALA A N   1 
ATOM   447  C  CA  . ALA A 1 63  ? 12.65908  12.65480  -4.00647  1.000 19.33023 ? 99  ALA A CA  1 
ATOM   448  C  C   . ALA A 1 63  ? 11.94128  12.60419  -2.67824  1.000 18.99768 ? 99  ALA A C   1 
ATOM   449  O  O   . ALA A 1 63  ? 12.49527  13.02704  -1.64773  1.000 20.32736 ? 99  ALA A O   1 
ATOM   450  C  CB  . ALA A 1 63  ? 12.16255  13.88477  -4.78558  1.000 19.70422 ? 99  ALA A CB  1 
ATOM   451  N  N   . PHE A 1 64  ? 10.69531  12.11550  -2.70177  1.000 18.46510 ? 100 PHE A N   1 
ATOM   452  C  CA  . PHE A 1 64  ? 9.88952   11.92585  -1.49634  1.000 18.92720 ? 100 PHE A CA  1 
ATOM   453  C  C   . PHE A 1 64  ? 10.62087  11.02718  -0.50534  1.000 18.94645 ? 100 PHE A C   1 
ATOM   454  O  O   . PHE A 1 64  ? 10.72412  11.34674  0.68656   1.000 22.45565 ? 100 PHE A O   1 
ATOM   455  C  CB  . PHE A 1 64  ? 8.52584   11.36042  -1.96088  1.000 16.38935 ? 100 PHE A CB  1 
ATOM   456  C  CG  . PHE A 1 64  ? 7.68460   10.69659  -0.89133  1.000 14.89030 ? 100 PHE A CG  1 
ATOM   457  C  CD1 . PHE A 1 64  ? 6.91278   11.48362  -0.00343  1.000 15.00778 ? 100 PHE A CD1 1 
ATOM   458  C  CD2 . PHE A 1 64  ? 7.58107   9.28533   -0.84677  1.000 15.48757 ? 100 PHE A CD2 1 
ATOM   459  C  CE1 . PHE A 1 64  ? 6.06215   10.88987  0.93041   1.000 13.55457 ? 100 PHE A CE1 1 
ATOM   460  C  CE2 . PHE A 1 64  ? 6.79206   8.64434   0.09753   1.000 12.24747 ? 100 PHE A CE2 1 
ATOM   461  C  CZ  . PHE A 1 64  ? 6.00875   9.46871   1.01892   1.000 14.12704 ? 100 PHE A CZ  1 
ATOM   462  N  N   . LEU A 1 65  ? 11.18489  9.92583   -0.99962  1.000 16.29476 ? 101 LEU A N   1 
ATOM   463  C  CA  . LEU A 1 65  ? 11.95525  8.99390   -0.17420  1.000 16.81025 ? 101 LEU A CA  1 
ATOM   464  C  C   . LEU A 1 65  ? 13.16626  9.66693   0.45752   1.000 17.87352 ? 101 LEU A C   1 
ATOM   465  O  O   . LEU A 1 65  ? 13.43264  9.52307   1.67359   1.000 17.21314 ? 101 LEU A O   1 
ATOM   466  C  CB  . LEU A 1 65  ? 12.41098  7.82742   -1.05875  1.000 16.12388 ? 101 LEU A CB  1 
ATOM   467  C  CG  . LEU A 1 65  ? 13.44402  6.85489   -0.44324  1.000 18.41350 ? 101 LEU A CG  1 
ATOM   468  C  CD1 . LEU A 1 65  ? 12.82411  6.09628   0.75584   1.000 16.69939 ? 101 LEU A CD1 1 
ATOM   469  C  CD2 . LEU A 1 65  ? 14.00125  5.81164   -1.51096  1.000 17.11645 ? 101 LEU A CD2 1 
ATOM   470  N  N   . GLU A 1 66  ? 13.90560  10.43272  -0.35646  1.000 18.25409 ? 102 GLU A N   1 
ATOM   471  C  CA  . GLU A 1 66  ? 15.18550  11.02898  0.06343   1.000 19.49794 ? 102 GLU A CA  1 
ATOM   472  C  C   . GLU A 1 66  ? 14.96911  12.09147  1.14058   1.000 20.36158 ? 102 GLU A C   1 
ATOM   473  O  O   . GLU A 1 66  ? 15.81159  12.26204  2.02922   1.000 22.14632 ? 102 GLU A O   1 
ATOM   474  C  CB  . GLU A 1 66  ? 15.85936  11.74288  -1.11479  1.000 21.39387 ? 102 GLU A CB  1 
ATOM   475  C  CG  . GLU A 1 66  ? 16.44309  10.79525  -2.13567  1.000 29.27459 ? 102 GLU A CG  1 
ATOM   476  C  CD  . GLU A 1 66  ? 17.76706  11.26998  -2.72677  1.000 35.57938 ? 102 GLU A CD  1 
ATOM   477  O  OE1 . GLU A 1 66  ? 18.07211  12.49540  -2.69167  1.000 39.47542 ? 102 GLU A OE1 1 
ATOM   478  O  OE2 . GLU A 1 66  ? 18.44858  10.40460  -3.31674  1.000 32.05650 ? 102 GLU A OE2 1 
ATOM   479  N  N   . ASN A 1 67  ? 13.84095  12.78383  1.07344   1.000 17.29187 ? 103 ASN A N   1 
ATOM   480  C  CA  . ASN A 1 67  ? 13.61417  13.94258  1.93162   1.000 20.68643 ? 103 ASN A CA  1 
ATOM   481  C  C   . ASN A 1 67  ? 13.31337  13.53040  3.38413   1.000 19.77867 ? 103 ASN A C   1 
ATOM   482  O  O   . ASN A 1 67  ? 13.27136  14.40659  4.26757   1.000 18.64109 ? 103 ASN A O   1 
ATOM   483  C  CB  . ASN A 1 67  ? 12.46340  14.75436  1.33893   1.000 21.36864 ? 103 ASN A CB  1 
ATOM   484  C  CG  . ASN A 1 67  ? 12.32944  16.14384  1.96784   1.000 23.72872 ? 103 ASN A CG  1 
ATOM   485  O  OD1 . ASN A 1 67  ? 13.34401  16.87648  2.21387   1.000 21.37896 ? 103 ASN A OD1 1 
ATOM   486  N  ND2 . ASN A 1 67  ? 11.09782  16.46572  2.34665   1.000 18.16720 ? 103 ASN A ND2 1 
ATOM   487  N  N   . PHE A 1 68  ? 13.09950  12.21145  3.66614   1.000 17.22038 ? 104 PHE A N   1 
ATOM   488  C  CA  . PHE A 1 68  ? 12.92738  11.76390  5.04870   1.000 17.22589 ? 104 PHE A CA  1 
ATOM   489  C  C   . PHE A 1 68  ? 14.24992  11.74323  5.78808   1.000 19.04341 ? 104 PHE A C   1 
ATOM   490  O  O   . PHE A 1 68  ? 14.22907  11.60381  7.02224   1.000 18.87844 ? 104 PHE A O   1 
ATOM   491  C  CB  . PHE A 1 68  ? 12.23556  10.38009  5.15244   1.000 16.76474 ? 104 PHE A CB  1 
ATOM   492  C  CG  . PHE A 1 68  ? 10.79970  10.46740  4.71689   1.000 16.24590 ? 104 PHE A CG  1 
ATOM   493  C  CD1 . PHE A 1 68  ? 9.94225   11.34730  5.39953   1.000 16.63684 ? 104 PHE A CD1 1 
ATOM   494  C  CD2 . PHE A 1 68  ? 10.35895  9.83212   3.58342   1.000 19.61053 ? 104 PHE A CD2 1 
ATOM   495  C  CE1 . PHE A 1 68  ? 8.60064   11.60470  4.93077   1.000 18.33911 ? 104 PHE A CE1 1 
ATOM   496  C  CE2 . PHE A 1 68  ? 9.03964   10.00732  3.16352   1.000 17.96198 ? 104 PHE A CE2 1 
ATOM   497  C  CZ  . PHE A 1 68  ? 8.16926   10.90156  3.84670   1.000 17.59310 ? 104 PHE A CZ  1 
ATOM   498  N  N   . LYS A 1 69  ? 15.36619  11.89954  5.06397   1.000 18.20128 ? 105 LYS A N   1 
ATOM   499  C  CA  . LYS A 1 69  ? 16.68928  12.09406  5.68856   1.000 20.49715 ? 105 LYS A CA  1 
ATOM   500  C  C   . LYS A 1 69  ? 16.93589  10.96075  6.68141   1.000 23.14850 ? 105 LYS A C   1 
ATOM   501  O  O   . LYS A 1 69  ? 17.27177  11.15611  7.86090   1.000 20.65011 ? 105 LYS A O   1 
ATOM   502  C  CB  . LYS A 1 69  ? 16.78096  13.47783  6.36994   1.000 22.41573 ? 105 LYS A CB  1 
ATOM   503  C  CG  . LYS A 1 69  ? 16.85250  14.65317  5.36510   1.000 24.34393 ? 105 LYS A CG  1 
ATOM   504  C  CD  . LYS A 1 69  ? 16.82394  15.99504  6.09244   1.000 24.97903 ? 105 LYS A CD  1 
ATOM   505  C  CE  . LYS A 1 69  ? 15.41044  16.54541  6.18752   1.000 21.97655 ? 105 LYS A CE  1 
ATOM   506  N  NZ  . LYS A 1 69  ? 14.94666  16.76288  4.76395   1.000 19.71762 ? 105 LYS A NZ  1 
ATOM   507  N  N   . MET A 1 70  ? 16.67780  9.75219   6.20238   1.000 19.13812 ? 106 MET A N   1 
ATOM   508  C  CA  . MET A 1 70  ? 16.58597  8.56707   7.03541   1.000 19.91455 ? 106 MET A CA  1 
ATOM   509  C  C   . MET A 1 70  ? 17.13992  7.39593   6.24292   1.000 18.12588 ? 106 MET A C   1 
ATOM   510  O  O   . MET A 1 70  ? 16.73961  7.18962   5.10465   1.000 18.72517 ? 106 MET A O   1 
ATOM   511  C  CB  . MET A 1 70  ? 15.12190  8.20542   7.36166   1.000 19.53140 ? 106 MET A CB  1 
ATOM   512  C  CG  . MET A 1 70  ? 15.04198  7.26027   8.51531   1.000 22.06794 ? 106 MET A CG  1 
ATOM   513  S  SD  . MET A 1 70  ? 13.30469  6.84886   8.86407   1.000 29.21210 ? 106 MET A SD  1 
ATOM   514  C  CE  . MET A 1 70  ? 12.69365  8.50796   9.19022   1.000 23.83599 ? 106 MET A CE  1 
ATOM   515  N  N   . THR A 1 71  ? 18.02440  6.60666   6.83444   1.000 16.48062 ? 107 THR A N   1 
ATOM   516  C  CA  . THR A 1 71  ? 18.47762  5.41574   6.08777   1.000 14.49650 ? 107 THR A CA  1 
ATOM   517  C  C   . THR A 1 71  ? 17.35207  4.38401   6.14342   1.000 15.00078 ? 107 THR A C   1 
ATOM   518  O  O   . THR A 1 71  ? 16.86123  4.04097   7.23246   1.000 15.74159 ? 107 THR A O   1 
ATOM   519  C  CB  . THR A 1 71  ? 19.77071  4.90249   6.68865   1.000 17.92165 ? 107 THR A CB  1 
ATOM   520  O  OG1 . THR A 1 71  ? 20.75279  5.94213   6.56888   1.000 17.95762 ? 107 THR A OG1 1 
ATOM   521  C  CG2 . THR A 1 71  ? 20.27296  3.64635   5.95078   1.000 15.78992 ? 107 THR A CG2 1 
ATOM   522  N  N   . LEU A 1 72  ? 16.89732  3.94126   4.97211   1.000 13.00771 ? 108 LEU A N   1 
ATOM   523  C  CA  . LEU A 1 72  ? 15.72626  3.08546   4.88014   1.000 11.99512 ? 108 LEU A CA  1 
ATOM   524  C  C   . LEU A 1 72  ? 16.00921  1.88131   3.97844   1.000 12.40335 ? 108 LEU A C   1 
ATOM   525  O  O   . LEU A 1 72  ? 16.47381  2.07226   2.85260   1.000 13.58432 ? 108 LEU A O   1 
ATOM   526  C  CB  . LEU A 1 72  ? 14.54657  3.86369   4.26587   1.000 10.66962 ? 108 LEU A CB  1 
ATOM   527  C  CG  . LEU A 1 72  ? 14.00192  4.86978   5.25731   1.000 11.53295 ? 108 LEU A CG  1 
ATOM   528  C  CD1 . LEU A 1 72  ? 13.09635  5.86209   4.51027   1.000 12.64847 ? 108 LEU A CD1 1 
ATOM   529  C  CD2 . LEU A 1 72  ? 13.21806  4.08211   6.37553   1.000 12.61149 ? 108 LEU A CD2 1 
ATOM   530  N  N   . TRP A 1 73  ? 15.62648  0.66763   4.42394   1.000 12.77836 ? 109 TRP A N   1 
ATOM   531  C  CA  . TRP A 1 73  ? 15.53026  -0.44514  3.46709   1.000 12.64227 ? 109 TRP A CA  1 
ATOM   532  C  C   . TRP A 1 73  ? 14.41458  -0.13879  2.47622   1.000 12.19036 ? 109 TRP A C   1 
ATOM   533  O  O   . TRP A 1 73  ? 13.33754  0.30246   2.87928   1.000 13.29118 ? 109 TRP A O   1 
ATOM   534  C  CB  . TRP A 1 73  ? 15.12637  -1.74489  4.16950   1.000 12.01997 ? 109 TRP A CB  1 
ATOM   535  C  CG  . TRP A 1 73  ? 16.20331  -2.43127  4.90663   1.000 12.14721 ? 109 TRP A CG  1 
ATOM   536  C  CD1 . TRP A 1 73  ? 16.10026  -2.89771  6.20667   1.000 12.94679 ? 109 TRP A CD1 1 
ATOM   537  C  CD2 . TRP A 1 73  ? 17.53964  -2.82914  4.43406   1.000 10.71978 ? 109 TRP A CD2 1 
ATOM   538  N  NE1 . TRP A 1 73  ? 17.26966  -3.57845  6.55267   1.000 11.83917 ? 109 TRP A NE1 1 
ATOM   539  C  CE2 . TRP A 1 73  ? 18.16031  -3.51774  5.49402   1.000 11.83093 ? 109 TRP A CE2 1 
ATOM   540  C  CE3 . TRP A 1 73  ? 18.25806  -2.63939  3.22805   1.000 12.36077 ? 109 TRP A CE3 1 
ATOM   541  C  CZ2 . TRP A 1 73  ? 19.43927  -4.05293  5.38995   1.000 13.44920 ? 109 TRP A CZ2 1 
ATOM   542  C  CZ3 . TRP A 1 73  ? 19.52420  -3.19207  3.11695   1.000 13.77596 ? 109 TRP A CZ3 1 
ATOM   543  C  CH2 . TRP A 1 73  ? 20.11045  -3.87329  4.19081   1.000 13.95578 ? 109 TRP A CH2 1 
ATOM   544  N  N   . ILE A 1 74  ? 14.64111  -0.44327  1.19768   1.000 11.05679 ? 110 ILE A N   1 
ATOM   545  C  CA  . ILE A 1 74  ? 13.56525  -0.38039  0.21452   1.000 11.57337 ? 110 ILE A CA  1 
ATOM   546  C  C   . ILE A 1 74  ? 13.48844  -1.72182  -0.49988  1.000 11.23921 ? 110 ILE A C   1 
ATOM   547  O  O   . ILE A 1 74  ? 14.33074  -2.58571  -0.31347  1.000 13.44984 ? 110 ILE A O   1 
ATOM   548  C  CB  . ILE A 1 74  ? 13.77211  0.78616   -0.77825  1.000 12.36965 ? 110 ILE A CB  1 
ATOM   549  C  CG1 . ILE A 1 74  ? 15.06590  0.61848   -1.59886  1.000 11.49535 ? 110 ILE A CG1 1 
ATOM   550  C  CG2 . ILE A 1 74  ? 13.69996  2.15794   0.02960   1.000 12.50686 ? 110 ILE A CG2 1 
ATOM   551  C  CD1 . ILE A 1 74  ? 15.19198  1.64015   -2.78395  1.000 12.21611 ? 110 ILE A CD1 1 
ATOM   552  N  N   . GLY A 1 75  ? 12.43134  -1.90091  -1.30034  1.000 12.43007 ? 111 GLY A N   1 
ATOM   553  C  CA  . GLY A 1 75  ? 12.08629  -3.23373  -1.78419  1.000 12.03920 ? 111 GLY A CA  1 
ATOM   554  C  C   . GLY A 1 75  ? 12.80005  -3.61428  -3.06714  1.000 14.06865 ? 111 GLY A C   1 
ATOM   555  O  O   . GLY A 1 75  ? 12.13258  -3.94729  -4.06096  1.000 12.66400 ? 111 GLY A O   1 
ATOM   556  N  N   . LEU A 1 76  ? 14.13399  -3.55501  -3.05061  1.000 11.90755 ? 112 LEU A N   1 
ATOM   557  C  CA  . LEU A 1 76  ? 14.94128  -3.92285  -4.22164  1.000 13.84878 ? 112 LEU A CA  1 
ATOM   558  C  C   . LEU A 1 76  ? 16.00279  -4.89442  -3.75039  1.000 12.54764 ? 112 LEU A C   1 
ATOM   559  O  O   . LEU A 1 76  ? 16.63390  -4.65504  -2.69443  1.000 14.18733 ? 112 LEU A O   1 
ATOM   560  C  CB  . LEU A 1 76  ? 15.54693  -2.64659  -4.85728  1.000 13.21126 ? 112 LEU A CB  1 
ATOM   561  C  CG  . LEU A 1 76  ? 16.37971  -2.85038  -6.13729  1.000 14.09033 ? 112 LEU A CG  1 
ATOM   562  C  CD1 . LEU A 1 76  ? 15.40254  -3.37136  -7.25424  1.000 15.08206 ? 112 LEU A CD1 1 
ATOM   563  C  CD2 . LEU A 1 76  ? 17.03420  -1.56619  -6.53640  1.000 15.83611 ? 112 LEU A CD2 1 
ATOM   564  N  N   . MET A 1 77  ? 16.18905  -6.00115  -4.49285  1.000 12.96176 ? 113 MET A N   1 
ATOM   565  C  CA  . MET A 1 77  ? 17.17860  -6.95202  -3.99423  1.000 13.42989 ? 113 MET A CA  1 
ATOM   566  C  C   . MET A 1 77  ? 17.84509  -7.61476  -5.20018  1.000 13.74562 ? 113 MET A C   1 
ATOM   567  O  O   . MET A 1 77  ? 17.27820  -7.69066  -6.28642  1.000 14.36234 ? 113 MET A O   1 
ATOM   568  C  CB  . MET A 1 77  ? 16.54762  -7.95730  -3.01070  1.000 17.65942 ? 113 MET A CB  1 
ATOM   569  C  CG  . MET A 1 77  ? 17.44576  -9.14150  -2.62735  1.000 19.31174 ? 113 MET A CG  1 
ATOM   570  S  SD  . MET A 1 77  ? 16.69044  -10.26481 -1.45944  1.000 26.87994 ? 113 MET A SD  1 
ATOM   571  C  CE  . MET A 1 77  ? 15.79099  -11.08530 -2.59960  1.000 21.07127 ? 113 MET A CE  1 
ATOM   572  N  N   . GLU A 1 78  ? 19.07949  -8.03367  -5.00641  1.000 12.72117 ? 114 GLU A N   1 
ATOM   573  C  CA  . GLU A 1 78  ? 19.85787  -8.62441  -6.10265  1.000 13.44975 ? 114 GLU A CA  1 
ATOM   574  C  C   . GLU A 1 78  ? 19.27931  -9.98470  -6.46555  1.000 16.74434 ? 114 GLU A C   1 
ATOM   575  O  O   . GLU A 1 78  ? 18.78996  -10.70653 -5.59771  1.000 16.69988 ? 114 GLU A O   1 
ATOM   576  C  CB  . GLU A 1 78  ? 21.32811  -8.78800  -5.63837  1.000 12.48019 ? 114 GLU A CB  1 
ATOM   577  C  CG  . GLU A 1 78  ? 22.30750  -9.15559  -6.78727  1.000 15.66004 ? 114 GLU A CG  1 
ATOM   578  C  CD  . GLU A 1 78  ? 23.71972  -9.20361  -6.27569  1.000 13.82534 ? 114 GLU A CD  1 
ATOM   579  O  OE1 . GLU A 1 78  ? 23.92456  -8.94545  -5.07659  1.000 14.90275 ? 114 GLU A OE1 1 
ATOM   580  O  OE2 . GLU A 1 78  ? 24.60875  -9.41447  -7.12102  1.000 13.97897 ? 114 GLU A OE2 1 
ATOM   581  N  N   . GLN A 1 79  ? 19.34958  -10.33756 -7.75195  1.000 17.21071 ? 115 GLN A N   1 
ATOM   582  C  CA  . GLN A 1 79  ? 19.05695  -11.70475 -8.20402  1.000 16.88939 ? 115 GLN A CA  1 
ATOM   583  C  C   . GLN A 1 79  ? 20.29699  -12.55643 -7.94511  1.000 19.31242 ? 115 GLN A C   1 
ATOM   584  O  O   . GLN A 1 79  ? 21.28315  -12.45652 -8.68265  1.000 20.47460 ? 115 GLN A O   1 
ATOM   585  C  CB  . GLN A 1 79  ? 18.70234  -11.71375 -9.68784  1.000 18.96904 ? 115 GLN A CB  1 
ATOM   586  C  CG  . GLN A 1 79  ? 17.47529  -10.89198 -9.96307  1.000 25.25984 ? 115 GLN A CG  1 
ATOM   587  C  CD  . GLN A 1 79  ? 17.12031  -10.80355 -11.43295 1.000 31.19600 ? 115 GLN A CD  1 
ATOM   588  O  OE1 . GLN A 1 79  ? 17.48620  -9.83432  -12.16074 1.000 34.22218 ? 115 GLN A OE1 1 
ATOM   589  N  NE2 . GLN A 1 79  ? 16.37217  -11.81012 -11.88629 1.000 34.84039 ? 115 GLN A NE2 1 
ATOM   590  N  N   . ARG A 1 80  ? 20.25541  -13.39035 -6.90670  1.000 20.28903 ? 116 ARG A N   1 
ATOM   591  C  CA  . ARG A 1 80  ? 21.37595  -14.24375 -6.51091  1.000 22.32693 ? 116 ARG A CA  1 
ATOM   592  C  C   . ARG A 1 80  ? 22.60052  -13.36136 -6.33584  1.000 22.61304 ? 116 ARG A C   1 
ATOM   593  O  O   . ARG A 1 80  ? 22.54531  -12.38430 -5.57273  1.000 22.33720 ? 116 ARG A O   1 
ATOM   594  C  CB  . ARG A 1 80  ? 21.57236  -15.39353 -7.51339  1.000 28.07991 ? 116 ARG A CB  1 
ATOM   595  C  CG  . ARG A 1 80  ? 20.27290  -16.02062 -7.97731  1.000 35.38580 ? 116 ARG A CG  1 
ATOM   596  C  CD  . ARG A 1 80  ? 20.45378  -17.21388 -8.86888  1.000 40.00207 ? 116 ARG A CD  1 
ATOM   597  N  NE  . ARG A 1 80  ? 20.55295  -16.84234 -10.28521 1.000 43.65669 ? 116 ARG A NE  1 
ATOM   598  C  CZ  . ARG A 1 80  ? 21.59832  -17.11774 -11.06567 1.000 44.65477 ? 116 ARG A CZ  1 
ATOM   599  N  NH1 . ARG A 1 80  ? 22.66643  -17.74681 -10.59693 1.000 44.73703 ? 116 ARG A NH1 1 
ATOM   600  N  NH2 . ARG A 1 80  ? 21.55400  -16.79102 -12.35993 1.000 43.23955 ? 116 ARG A NH2 1 
ATOM   601  N  N   . SER A 1 81  ? 23.71005  -13.67621 -6.99479  1.000 18.83254 ? 117 SER A N   1 
ATOM   602  C  CA  . SER A 1 81  ? 24.89414  -12.84195 -6.97422  1.000 20.11899 ? 117 SER A CA  1 
ATOM   603  C  C   . SER A 1 81  ? 25.14934  -12.22607 -8.34584  1.000 18.05119 ? 117 SER A C   1 
ATOM   604  O  O   . SER A 1 81  ? 26.27732  -11.82868 -8.64735  1.000 17.45420 ? 117 SER A O   1 
ATOM   605  C  CB  . SER A 1 81  ? 26.09813  -13.66406 -6.50995  1.000 22.67484 ? 117 SER A CB  1 
ATOM   606  O  OG  . SER A 1 81  ? 25.86655  -14.20441 -5.21191  1.000 22.85084 ? 117 SER A OG  1 
ATOM   607  N  N   . GLU A 1 82  ? 24.08778  -12.05785 -9.16166  1.000 16.38467 ? 118 GLU A N   1 
ATOM   608  C  CA  . GLU A 1 82  ? 24.29268  -11.71280 -10.56325 1.000 16.54015 ? 118 GLU A CA  1 
ATOM   609  C  C   . GLU A 1 82  ? 24.52947  -10.23527 -10.80766 1.000 16.13223 ? 118 GLU A C   1 
ATOM   610  O  O   . GLU A 1 82  ? 24.79908  -9.87843  -11.96683 1.000 15.75319 ? 118 GLU A O   1 
ATOM   611  C  CB  . GLU A 1 82  ? 23.09298  -12.14732 -11.38507 1.000 18.41663 ? 118 GLU A CB  1 
ATOM   612  C  CG  . GLU A 1 82  ? 22.96109  -13.66377 -11.39651 1.000 19.94652 ? 118 GLU A CG  1 
ATOM   613  C  CD  . GLU A 1 82  ? 24.15615  -14.30425 -12.12665 1.000 27.68335 ? 118 GLU A CD  1 
ATOM   614  O  OE1 . GLU A 1 82  ? 24.22648  -14.15175 -13.35972 1.000 29.16182 ? 118 GLU A OE1 1 
ATOM   615  O  OE2 . GLU A 1 82  ? 25.02699  -14.92311 -11.48869 1.000 26.76300 ? 118 GLU A OE2 1 
ATOM   616  N  N   . ARG A 1 83  ? 24.41907  -9.37356  -9.78519  1.000 14.74762 ? 119 ARG A N   1 
ATOM   617  C  CA  . ARG A 1 83  ? 24.55336  -7.91536  -9.98421  1.000 14.69409 ? 119 ARG A CA  1 
ATOM   618  C  C   . ARG A 1 83  ? 23.51196  -7.44377  -10.96144 1.000 15.77079 ? 119 ARG A C   1 
ATOM   619  O  O   . ARG A 1 83  ? 23.73023  -6.47600  -11.70347 1.000 15.31988 ? 119 ARG A O   1 
ATOM   620  C  CB  . ARG A 1 83  ? 25.94779  -7.47074  -10.46542 1.000 16.15234 ? 119 ARG A CB  1 
ATOM   621  C  CG  . ARG A 1 83  ? 27.07946  -7.91950  -9.47887  1.000 13.17994 ? 119 ARG A CG  1 
ATOM   622  C  CD  . ARG A 1 83  ? 27.25037  -6.91285  -8.35293  1.000 15.77560 ? 119 ARG A CD  1 
ATOM   623  N  NE  . ARG A 1 83  ? 26.34352  -7.05539  -7.20538  1.000 14.06638 ? 119 ARG A NE  1 
ATOM   624  C  CZ  . ARG A 1 83  ? 26.31502  -6.14558  -6.24452  1.000 13.14309 ? 119 ARG A CZ  1 
ATOM   625  N  NH1 . ARG A 1 83  ? 27.06693  -5.04465  -6.32111  1.000 14.75490 ? 119 ARG A NH1 1 
ATOM   626  N  NH2 . ARG A 1 83  ? 25.50225  -6.31450  -5.21753  1.000 15.48155 ? 119 ARG A NH2 1 
ATOM   627  N  N   . THR A 1 84  ? 22.35133  -8.10507  -10.93031 1.000 15.36727 ? 120 THR A N   1 
ATOM   628  C  CA  . THR A 1 84  ? 21.15860  -7.49596  -11.52693 1.000 14.42021 ? 120 THR A CA  1 
ATOM   629  C  C   . THR A 1 84  ? 20.09925  -7.45414  -10.42483 1.000 14.37764 ? 120 THR A C   1 
ATOM   630  O  O   . THR A 1 84  ? 20.22060  -8.16145  -9.41839  1.000 14.81532 ? 120 THR A O   1 
ATOM   631  C  CB  . THR A 1 84  ? 20.67267  -8.28518  -12.72177 1.000 15.54688 ? 120 THR A CB  1 
ATOM   632  O  OG1 . THR A 1 84  ? 20.44030  -9.62355  -12.27966 1.000 19.04002 ? 120 THR A OG1 1 
ATOM   633  C  CG2 . THR A 1 84  ? 21.79268  -8.23983  -13.80721 1.000 16.62686 ? 120 THR A CG2 1 
ATOM   634  N  N   . TRP A 1 85  ? 19.05782  -6.64249  -10.62785 1.000 14.41567 ? 121 TRP A N   1 
ATOM   635  C  CA  . TRP A 1 85  ? 18.20300  -6.24550  -9.49462  1.000 14.06432 ? 121 TRP A CA  1 
ATOM   636  C  C   . TRP A 1 85  ? 16.72749  -6.40536  -9.84802  1.000 17.39423 ? 121 TRP A C   1 
ATOM   637  O  O   . TRP A 1 85  ? 16.31112  -6.07919  -10.96718 1.000 16.06063 ? 121 TRP A O   1 
ATOM   638  C  CB  . TRP A 1 85  ? 18.51823  -4.76007  -9.13118  1.000 14.41663 ? 121 TRP A CB  1 
ATOM   639  C  CG  . TRP A 1 85  ? 19.98202  -4.62177  -8.82223  1.000 13.63436 ? 121 TRP A CG  1 
ATOM   640  C  CD1 . TRP A 1 85  ? 21.01886  -4.36005  -9.72526  1.000 14.93544 ? 121 TRP A CD1 1 
ATOM   641  C  CD2 . TRP A 1 85  ? 20.60221  -4.82274  -7.54909  1.000 15.38135 ? 121 TRP A CD2 1 
ATOM   642  N  NE1 . TRP A 1 85  ? 22.22323  -4.37053  -9.06908  1.000 14.93066 ? 121 TRP A NE1 1 
ATOM   643  C  CE2 . TRP A 1 85  ? 21.99599  -4.62820  -7.72782  1.000 14.12768 ? 121 TRP A CE2 1 
ATOM   644  C  CE3 . TRP A 1 85  ? 20.11235  -5.09259  -6.26678  1.000 12.18104 ? 121 TRP A CE3 1 
ATOM   645  C  CZ2 . TRP A 1 85  ? 22.91595  -4.77636  -6.66244  1.000 14.76085 ? 121 TRP A CZ2 1 
ATOM   646  C  CZ3 . TRP A 1 85  ? 21.03316  -5.23289  -5.18482  1.000 13.62515 ? 121 TRP A CZ3 1 
ATOM   647  C  CH2 . TRP A 1 85  ? 22.40064  -5.09849  -5.39490  1.000 12.72721 ? 121 TRP A CH2 1 
ATOM   648  N  N   . ARG A 1 86  ? 15.93141  -6.90693  -8.88804  1.000 15.48780 ? 122 ARG A N   1 
ATOM   649  C  CA  . ARG A 1 86  ? 14.50526  -7.06176  -9.09508  1.000 15.86269 ? 122 ARG A CA  1 
ATOM   650  C  C   . ARG A 1 86  ? 13.77593  -6.38959  -7.93658  1.000 14.18202 ? 122 ARG A C   1 
ATOM   651  O  O   . ARG A 1 86  ? 14.17908  -6.58348  -6.78558  1.000 16.05458 ? 122 ARG A O   1 
ATOM   652  C  CB  . ARG A 1 86  ? 14.16092  -8.57447  -9.13989  1.000 22.08099 ? 122 ARG A CB  1 
ATOM   653  C  CG  . ARG A 1 86  ? 12.85763  -8.83950  -9.80025  1.000 26.02360 ? 122 ARG A CG  1 
ATOM   654  C  CD  . ARG A 1 86  ? 12.75868  -10.26052 -10.46042 1.000 27.76586 ? 122 ARG A CD  1 
ATOM   655  N  NE  . ARG A 1 86  ? 13.59832  -10.40889 -11.65061 1.000 36.06011 ? 122 ARG A NE  1 
ATOM   656  C  CZ  . ARG A 1 86  ? 13.31971  -9.96597  -12.87971 1.000 39.13548 ? 122 ARG A CZ  1 
ATOM   657  N  NH1 . ARG A 1 86  ? 12.17215  -9.34612  -13.17623 1.000 33.95291 ? 122 ARG A NH1 1 
ATOM   658  N  NH2 . ARG A 1 86  ? 14.23189  -10.11857 -13.83750 1.000 46.49061 ? 122 ARG A NH2 1 
ATOM   659  N  N   . TRP A 1 87  ? 12.69127  -5.65415  -8.23212  1.000 13.45676 ? 123 TRP A N   1 
ATOM   660  C  CA  . TRP A 1 87  ? 11.87049  -5.10844  -7.12535  1.000 12.24295 ? 123 TRP A CA  1 
ATOM   661  C  C   . TRP A 1 87  ? 11.06399  -6.24123  -6.48161  1.000 12.35867 ? 123 TRP A C   1 
ATOM   662  O  O   . TRP A 1 87  ? 10.88319  -7.30691  -7.07710  1.000 15.14692 ? 123 TRP A O   1 
ATOM   663  C  CB  . TRP A 1 87  ? 10.92857  -4.02705  -7.66373  1.000 12.16548 ? 123 TRP A CB  1 
ATOM   664  C  CG  . TRP A 1 87  ? 11.64970  -2.81051  -8.16661  1.000 12.04402 ? 123 TRP A CG  1 
ATOM   665  C  CD1 . TRP A 1 87  ? 11.97180  -2.44410  -9.49523  1.000 11.13144 ? 123 TRP A CD1 1 
ATOM   666  C  CD2 . TRP A 1 87  ? 12.11871  -1.76776  -7.33029  1.000 12.67248 ? 123 TRP A CD2 1 
ATOM   667  N  NE1 . TRP A 1 87  ? 12.65278  -1.21676  -9.47497  1.000 13.57084 ? 123 TRP A NE1 1 
ATOM   668  C  CE2 . TRP A 1 87  ? 12.72280  -0.76867  -8.16898  1.000 11.66461 ? 123 TRP A CE2 1 
ATOM   669  C  CE3 . TRP A 1 87  ? 12.06195  -1.56048  -5.93773  1.000 11.46939 ? 123 TRP A CE3 1 
ATOM   670  C  CZ2 . TRP A 1 87  ? 13.29549  0.39001   -7.64795  1.000 12.13433 ? 123 TRP A CZ2 1 
ATOM   671  C  CZ3 . TRP A 1 87  ? 12.67246  -0.34169  -5.41846  1.000 11.71954 ? 123 TRP A CZ3 1 
ATOM   672  C  CH2 . TRP A 1 87  ? 13.24511  0.57087   -6.25321  1.000 12.26041 ? 123 TRP A CH2 1 
ATOM   673  N  N   . VAL A 1 88  ? 10.51194  -5.99536  -5.27720  1.000 13.25289 ? 124 VAL A N   1 
ATOM   674  C  CA  . VAL A 1 88  ? 9.79489   -7.07363  -4.55980  1.000 13.01184 ? 124 VAL A CA  1 
ATOM   675  C  C   . VAL A 1 88  ? 8.52432   -7.52509  -5.25783  1.000 14.80952 ? 124 VAL A C   1 
ATOM   676  O  O   . VAL A 1 88  ? 8.00749   -8.61496  -4.93454  1.000 15.75931 ? 124 VAL A O   1 
ATOM   677  C  CB  . VAL A 1 88  ? 9.49270   -6.63426  -3.11117  1.000 13.54049 ? 124 VAL A CB  1 
ATOM   678  C  CG1 . VAL A 1 88  ? 10.78948  -6.68365  -2.27184  1.000 13.55524 ? 124 VAL A CG1 1 
ATOM   679  C  CG2 . VAL A 1 88  ? 8.92679   -5.16588  -3.11626  1.000 13.66911 ? 124 VAL A CG2 1 
ATOM   680  N  N   . ASP A 1 89  ? 8.00477   -6.72276  -6.19849  1.000 12.65679 ? 125 ASP A N   1 
ATOM   681  C  CA  . ASP A 1 89  ? 6.85812   -7.15643  -6.99428  1.000 16.37093 ? 125 ASP A CA  1 
ATOM   682  C  C   . ASP A 1 89  ? 7.25959   -8.00896  -8.18607  1.000 19.49127 ? 125 ASP A C   1 
ATOM   683  O  O   . ASP A 1 89  ? 6.37776   -8.38304  -8.97703  1.000 19.80355 ? 125 ASP A O   1 
ATOM   684  C  CB  . ASP A 1 89  ? 6.00907   -5.95587  -7.45188  1.000 18.82968 ? 125 ASP A CB  1 
ATOM   685  C  CG  . ASP A 1 89  ? 6.69236   -5.08185  -8.44178  1.000 19.15912 ? 125 ASP A CG  1 
ATOM   686  O  OD1 . ASP A 1 89  ? 7.89428   -5.23198  -8.69113  1.000 18.26409 ? 125 ASP A OD1 1 
ATOM   687  O  OD2 . ASP A 1 89  ? 6.01016   -4.20085  -8.98997  1.000 20.12122 ? 125 ASP A OD2 1 
ATOM   688  N  N   . GLY A 1 90  ? 8.57249   -8.22977  -8.38043  1.000 16.00891 ? 126 GLY A N   1 
ATOM   689  C  CA  . GLY A 1 90  ? 9.08765   -9.06207  -9.45876  1.000 17.05576 ? 126 GLY A CA  1 
ATOM   690  C  C   . GLY A 1 90  ? 9.55678   -8.26156  -10.67474 1.000 19.35210 ? 126 GLY A C   1 
ATOM   691  O  O   . GLY A 1 90  ? 10.09310  -8.85792  -11.62693 1.000 22.58382 ? 126 GLY A O   1 
ATOM   692  N  N   . THR A 1 91  ? 9.33817   -6.96550  -10.69420 1.000 16.92634 ? 127 THR A N   1 
ATOM   693  C  CA  . THR A 1 91  ? 9.69157   -6.21932  -11.90919 1.000 17.15704 ? 127 THR A CA  1 
ATOM   694  C  C   . THR A 1 91  ? 11.20102  -5.97198  -11.93319 1.000 18.36345 ? 127 THR A C   1 
ATOM   695  O  O   . THR A 1 91  ? 11.80845  -5.71902  -10.88212 1.000 18.50615 ? 127 THR A O   1 
ATOM   696  C  CB  . THR A 1 91  ? 8.96779   -4.86455  -11.97733 1.000 20.21584 ? 127 THR A CB  1 
ATOM   697  O  OG1 . THR A 1 91  ? 9.20663   -4.15298  -10.76983 1.000 20.32956 ? 127 THR A OG1 1 
ATOM   698  C  CG2 . THR A 1 91  ? 7.46300   -5.04992  -12.12153 1.000 19.53028 ? 127 THR A CG2 1 
ATOM   699  N  N   . PRO A 1 92  ? 11.84715  -5.99932  -13.09140 1.000 21.51557 ? 128 PRO A N   1 
ATOM   700  C  CA  . PRO A 1 92  ? 13.29680  -5.72359  -13.10289 1.000 20.13428 ? 128 PRO A CA  1 
ATOM   701  C  C   . PRO A 1 92  ? 13.55757  -4.24061  -12.87307 1.000 17.62600 ? 128 PRO A C   1 
ATOM   702  O  O   . PRO A 1 92  ? 12.71814  -3.38627  -13.16489 1.000 17.34130 ? 128 PRO A O   1 
ATOM   703  C  CB  . PRO A 1 92  ? 13.73142  -6.13008  -14.51403 1.000 20.47806 ? 128 PRO A CB  1 
ATOM   704  C  CG  . PRO A 1 92  ? 12.40029  -5.79720  -15.34128 1.000 22.91942 ? 128 PRO A CG  1 
ATOM   705  C  CD  . PRO A 1 92  ? 11.29774  -6.23751  -14.44123 1.000 22.49196 ? 128 PRO A CD  1 
ATOM   706  N  N   . LEU A 1 93  ? 14.76159  -3.93313  -12.36897 1.000 17.76672 ? 129 LEU A N   1 
ATOM   707  C  CA  . LEU A 1 93  ? 15.19079  -2.54566  -12.24086 1.000 15.96966 ? 129 LEU A CA  1 
ATOM   708  C  C   . LEU A 1 93  ? 15.24858  -1.83979  -13.60076 1.000 19.46186 ? 129 LEU A C   1 
ATOM   709  O  O   . LEU A 1 93  ? 15.87593  -2.33970  -14.53820 1.000 19.61816 ? 129 LEU A O   1 
ATOM   710  C  CB  . LEU A 1 93  ? 16.57154  -2.56210  -11.56902 1.000 16.99922 ? 129 LEU A CB  1 
ATOM   711  C  CG  . LEU A 1 93  ? 17.16330  -1.18812  -11.29529 1.000 16.45322 ? 129 LEU A CG  1 
ATOM   712  C  CD1 . LEU A 1 93  ? 16.20794  -0.34000  -10.42229 1.000 15.73428 ? 129 LEU A CD1 1 
ATOM   713  C  CD2 . LEU A 1 93  ? 18.53494  -1.32714  -10.65921 1.000 20.00898 ? 129 LEU A CD2 1 
ATOM   714  N  N   . THR A 1 94  ? 14.53459  -0.71449  -13.74279 1.000 17.88774 ? 130 THR A N   1 
ATOM   715  C  CA  . THR A 1 94  ? 14.78143  0.07870   -14.92994 1.000 21.89424 ? 130 THR A CA  1 
ATOM   716  C  C   . THR A 1 94  ? 15.43890  1.41144   -14.53553 1.000 20.33053 ? 130 THR A C   1 
ATOM   717  O  O   . THR A 1 94  ? 16.65090  1.39382   -14.30283 1.000 22.59220 ? 130 THR A O   1 
ATOM   718  C  CB  . THR A 1 94  ? 13.45995  0.26497   -15.68050 1.000 21.63911 ? 130 THR A CB  1 
ATOM   719  O  OG1 . THR A 1 94  ? 12.43058  0.58366   -14.75291 1.000 23.43149 ? 130 THR A OG1 1 
ATOM   720  C  CG2 . THR A 1 94  ? 13.04545  -1.00293  -16.35744 1.000 20.27982 ? 130 THR A CG2 1 
ATOM   721  N  N   . GLU A 1 95  ? 14.68778  2.45876   -14.18276 1.000 19.95121 ? 131 GLU A N   1 
ATOM   722  C  CA  . GLU A 1 95  ? 15.33554  3.69656   -13.72479 1.000 20.08598 ? 131 GLU A CA  1 
ATOM   723  C  C   . GLU A 1 95  ? 15.85517  3.51630   -12.30514 1.000 21.52157 ? 131 GLU A C   1 
ATOM   724  O  O   . GLU A 1 95  ? 15.16267  2.94434   -11.44786 1.000 20.80411 ? 131 GLU A O   1 
ATOM   725  C  CB  . GLU A 1 95  ? 14.35717  4.87856   -13.76531 1.000 25.92998 ? 131 GLU A CB  1 
ATOM   726  C  CG  . GLU A 1 95  ? 13.61425  5.04872   -15.07723 1.000 33.80428 ? 131 GLU A CG  1 
ATOM   727  C  CD  . GLU A 1 95  ? 12.19541  5.56823   -14.88560 1.000 48.81229 ? 131 GLU A CD  1 
ATOM   728  O  OE1 . GLU A 1 95  ? 11.97051  6.59802   -14.14908 1.000 36.84487 ? 131 GLU A OE1 1 
ATOM   729  O  OE2 . GLU A 1 95  ? 11.30644  4.90734   -15.47588 1.000 48.38877 ? 131 GLU A OE2 1 
ATOM   730  N  N   . SER A 1 96  ? 17.07400  3.98282   -12.06544 1.000 18.20850 ? 132 SER A N   1 
ATOM   731  C  CA  . SER A 1 96  ? 17.79285  3.72713   -10.81661 1.000 20.70384 ? 132 SER A CA  1 
ATOM   732  C  C   . SER A 1 96  ? 18.32506  5.03511   -10.22899 1.000 17.18138 ? 132 SER A C   1 
ATOM   733  O  O   . SER A 1 96  ? 18.47871  6.06438   -10.93033 1.000 15.55122 ? 132 SER A O   1 
ATOM   734  C  CB  . SER A 1 96  ? 18.94475  2.71367   -11.04508 1.000 19.71891 ? 132 SER A CB  1 
ATOM   735  O  OG  . SER A 1 96  ? 19.85105  3.25601   -11.99306 1.000 21.90661 ? 132 SER A OG  1 
ATOM   736  N  N   . TYR A 1 97  ? 18.59082  5.00812   -8.91023  1.000 17.48213 ? 133 TYR A N   1 
ATOM   737  C  CA  . TYR A 1 97  ? 19.11012  6.18544   -8.21087  1.000 18.46523 ? 133 TYR A CA  1 
ATOM   738  C  C   . TYR A 1 97  ? 20.26299  5.78192   -7.29592  1.000 17.21921 ? 133 TYR A C   1 
ATOM   739  O  O   . TYR A 1 97  ? 20.33895  6.18287   -6.12650  1.000 18.03643 ? 133 TYR A O   1 
ATOM   740  C  CB  . TYR A 1 97  ? 18.02388  6.92715   -7.41578  1.000 16.81597 ? 133 TYR A CB  1 
ATOM   741  C  CG  . TYR A 1 97  ? 16.89840  7.29893   -8.32803  1.000 19.35745 ? 133 TYR A CG  1 
ATOM   742  C  CD1 . TYR A 1 97  ? 16.97042  8.46826   -9.09325  1.000 21.88864 ? 133 TYR A CD1 1 
ATOM   743  C  CD2 . TYR A 1 97  ? 15.78715  6.47679   -8.46887  1.000 17.49280 ? 133 TYR A CD2 1 
ATOM   744  C  CE1 . TYR A 1 97  ? 15.94287  8.82827   -9.95859  1.000 22.25410 ? 133 TYR A CE1 1 
ATOM   745  C  CE2 . TYR A 1 97  ? 14.75240  6.81711   -9.35171  1.000 17.51947 ? 133 TYR A CE2 1 
ATOM   746  C  CZ  . TYR A 1 97  ? 14.84122  8.00725   -10.09006 1.000 23.18694 ? 133 TYR A CZ  1 
ATOM   747  O  OH  . TYR A 1 97  ? 13.85294  8.38545   -11.01339 1.000 21.97704 ? 133 TYR A OH  1 
ATOM   748  N  N   . TRP A 1 98  ? 21.18891  4.99322   -7.83822  1.000 16.20732 ? 134 TRP A N   1 
ATOM   749  C  CA  . TRP A 1 98  ? 22.31175  4.55909   -7.02421  1.000 17.90638 ? 134 TRP A CA  1 
ATOM   750  C  C   . TRP A 1 98  ? 23.11404  5.77270   -6.63514  1.000 20.48695 ? 134 TRP A C   1 
ATOM   751  O  O   . TRP A 1 98  ? 23.31070  6.68331   -7.45451  1.000 20.01866 ? 134 TRP A O   1 
ATOM   752  C  CB  . TRP A 1 98  ? 23.23583  3.60859   -7.78901  1.000 17.56228 ? 134 TRP A CB  1 
ATOM   753  C  CG  . TRP A 1 98  ? 22.63790  2.31394   -8.17753  1.000 15.86080 ? 134 TRP A CG  1 
ATOM   754  C  CD1 . TRP A 1 98  ? 22.30684  1.93604   -9.44454  1.000 17.59899 ? 134 TRP A CD1 1 
ATOM   755  C  CD2 . TRP A 1 98  ? 22.33174  1.19744   -7.33063  1.000 17.40373 ? 134 TRP A CD2 1 
ATOM   756  N  NE1 . TRP A 1 98  ? 21.77092  0.68600   -9.43995  1.000 18.05330 ? 134 TRP A NE1 1 
ATOM   757  C  CE2 . TRP A 1 98  ? 21.78865  0.19341   -8.16310  1.000 18.85004 ? 134 TRP A CE2 1 
ATOM   758  C  CE3 . TRP A 1 98  ? 22.42988  0.97046   -5.94937  1.000 16.66111 ? 134 TRP A CE3 1 
ATOM   759  C  CZ2 . TRP A 1 98  ? 21.37062  -1.04852  -7.69274  1.000 14.80959 ? 134 TRP A CZ2 1 
ATOM   760  C  CZ3 . TRP A 1 98  ? 21.97014  -0.27654  -5.45673  1.000 15.53950 ? 134 TRP A CZ3 1 
ATOM   761  C  CH2 . TRP A 1 98  ? 21.44578  -1.26119  -6.33994  1.000 16.29458 ? 134 TRP A CH2 1 
ATOM   762  N  N   . SER A 1 99  ? 23.55066  5.81773   -5.38269  1.000 21.23301 ? 135 SER A N   1 
ATOM   763  C  CA  A SER A 1 99  ? 24.48008  6.87292   -5.02451  0.691 21.44467 ? 135 SER A CA  1 
ATOM   764  C  CA  B SER A 1 99  ? 24.48715  6.84814   -4.99717  0.309 21.48588 ? 135 SER A CA  1 
ATOM   765  C  C   . SER A 1 99  ? 25.81711  6.60517   -5.71076  1.000 23.43073 ? 135 SER A C   1 
ATOM   766  O  O   . SER A 1 99  ? 26.08584  5.51555   -6.22578  1.000 19.74322 ? 135 SER A O   1 
ATOM   767  C  CB  A SER A 1 99  ? 24.64032  7.00590   -3.49788  0.691 24.74886 ? 135 SER A CB  1 
ATOM   768  C  CB  B SER A 1 99  ? 24.64816  6.85818   -3.47999  0.309 24.82556 ? 135 SER A CB  1 
ATOM   769  O  OG  A SER A 1 99  ? 25.00738  5.79262   -2.85362  0.691 22.51846 ? 135 SER A OG  1 
ATOM   770  O  OG  B SER A 1 99  ? 25.55831  7.84510   -3.08233  0.309 29.35862 ? 135 SER A OG  1 
ATOM   771  N  N   . LEU A 1 100 ? 26.65069  7.62977   -5.75515  1.000 23.56210 ? 136 LEU A N   1 
ATOM   772  C  CA  . LEU A 1 100 ? 27.89625  7.52175   -6.51529  1.000 26.42801 ? 136 LEU A CA  1 
ATOM   773  C  C   . LEU A 1 100 ? 28.78248  6.35469   -6.04460  1.000 23.11629 ? 136 LEU A C   1 
ATOM   774  O  O   . LEU A 1 100 ? 29.05117  6.19952   -4.85529  1.000 24.45573 ? 136 LEU A O   1 
ATOM   775  C  CB  . LEU A 1 100 ? 28.64640  8.84784   -6.38555  1.000 32.50410 ? 136 LEU A CB  1 
ATOM   776  C  CG  . LEU A 1 100 ? 29.75808  9.11452   -7.38246  1.000 37.63254 ? 136 LEU A CG  1 
ATOM   777  C  CD1 . LEU A 1 100 ? 29.15957  9.91789   -8.54929  1.000 39.14220 ? 136 LEU A CD1 1 
ATOM   778  C  CD2 . LEU A 1 100 ? 30.89304  9.87170   -6.67973  1.000 38.55615 ? 136 LEU A CD2 1 
ATOM   779  N  N   . GLY A 1 101 ? 29.26826  5.54424   -6.97934  1.000 19.73662 ? 137 GLY A N   1 
ATOM   780  C  CA  . GLY A 1 101 ? 30.12383  4.44888   -6.56481  1.000 19.91017 ? 137 GLY A CA  1 
ATOM   781  C  C   . GLY A 1 101 ? 29.37003  3.15887   -6.27112  1.000 19.62901 ? 137 GLY A C   1 
ATOM   782  O  O   . GLY A 1 101 ? 30.00443  2.10171   -6.12149  1.000 20.74069 ? 137 GLY A O   1 
ATOM   783  N  N   . GLU A 1 102 ? 28.04027  3.18559   -6.30136  1.000 19.13180 ? 138 GLU A N   1 
ATOM   784  C  CA  . GLU A 1 102 ? 27.23310  2.00242   -5.95933  1.000 15.40546 ? 138 GLU A CA  1 
ATOM   785  C  C   . GLU A 1 102 ? 26.49958  1.48865   -7.19620  1.000 16.67156 ? 138 GLU A C   1 
ATOM   786  O  O   . GLU A 1 102 ? 26.25358  2.23813   -8.14954  1.000 20.39870 ? 138 GLU A O   1 
ATOM   787  C  CB  . GLU A 1 102 ? 26.17551  2.33919   -4.88333  1.000 16.55293 ? 138 GLU A CB  1 
ATOM   788  C  CG  . GLU A 1 102 ? 26.74104  3.03159   -3.64189  1.000 16.15343 ? 138 GLU A CG  1 
ATOM   789  C  CD  . GLU A 1 102 ? 27.68315  2.15657   -2.83176  1.000 17.29388 ? 138 GLU A CD  1 
ATOM   790  O  OE1 . GLU A 1 102 ? 27.65882  0.92370   -3.01052  1.000 16.89146 ? 138 GLU A OE1 1 
ATOM   791  O  OE2 . GLU A 1 102 ? 28.43801  2.71049   -1.96871  1.000 18.09864 ? 138 GLU A OE2 1 
ATOM   792  N  N   . PRO A 1 103 ? 26.13287  0.20608   -7.21050  1.000 17.77404 ? 139 PRO A N   1 
ATOM   793  C  CA  . PRO A 1 103 ? 26.35291  -0.80840  -6.14989  1.000 15.60363 ? 139 PRO A CA  1 
ATOM   794  C  C   . PRO A 1 103 ? 27.76763  -1.37039  -6.23558  1.000 14.03879 ? 139 PRO A C   1 
ATOM   795  O  O   . PRO A 1 103 ? 28.37174  -1.34123  -7.34050  1.000 18.11599 ? 139 PRO A O   1 
ATOM   796  C  CB  . PRO A 1 103 ? 25.26617  -1.87273  -6.43918  1.000 13.47862 ? 139 PRO A CB  1 
ATOM   797  C  CG  . PRO A 1 103 ? 25.06856  -1.78619  -7.99747  1.000 13.67084 ? 139 PRO A CG  1 
ATOM   798  C  CD  . PRO A 1 103 ? 25.46875  -0.35148  -8.41345  1.000 17.00024 ? 139 PRO A CD  1 
ATOM   799  N  N   . ASN A 1 104 ? 28.33327  -1.82942  -5.12310  1.000 15.41996 ? 140 ASN A N   1 
ATOM   800  C  CA  . ASN A 1 104 ? 29.75826  -2.13254  -5.14858  1.000 16.33666 ? 140 ASN A CA  1 
ATOM   801  C  C   . ASN A 1 104 ? 30.21671  -3.36824  -4.39010  1.000 17.48657 ? 140 ASN A C   1 
ATOM   802  O  O   . ASN A 1 104 ? 31.43543  -3.60932  -4.39069  1.000 17.06355 ? 140 ASN A O   1 
ATOM   803  C  CB  . ASN A 1 104 ? 30.54973  -0.91275  -4.62976  1.000 16.74386 ? 140 ASN A CB  1 
ATOM   804  C  CG  . ASN A 1 104 ? 30.33077  -0.66065  -3.13255  1.000 17.80626 ? 140 ASN A CG  1 
ATOM   805  O  OD1 . ASN A 1 104 ? 29.50582  -1.32062  -2.51422  1.000 15.34911 ? 140 ASN A OD1 1 
ATOM   806  N  ND2 . ASN A 1 104 ? 31.09236  0.29527   -2.54277  1.000 18.40415 ? 140 ASN A ND2 1 
ATOM   807  N  N   . ASN A 1 105 ? 29.32826  -4.15788  -3.73294  1.000 16.18050 ? 141 ASN A N   1 
ATOM   808  C  CA  . ASN A 1 105 ? 29.79416  -5.33131  -2.95473  1.000 15.00111 ? 141 ASN A CA  1 
ATOM   809  C  C   . ASN A 1 105 ? 31.02220  -4.95412  -2.11769  1.000 15.86591 ? 141 ASN A C   1 
ATOM   810  O  O   . ASN A 1 105 ? 32.06857  -5.60556  -2.17949  1.000 20.34753 ? 141 ASN A O   1 
ATOM   811  C  CB  . ASN A 1 105 ? 30.13461  -6.52938  -3.84028  1.000 17.97271 ? 141 ASN A CB  1 
ATOM   812  C  CG  . ASN A 1 105 ? 28.89182  -7.35921  -4.16241  1.000 17.23166 ? 141 ASN A CG  1 
ATOM   813  O  OD1 . ASN A 1 105 ? 27.98426  -7.48091  -3.32460  1.000 18.04833 ? 141 ASN A OD1 1 
ATOM   814  N  ND2 . ASN A 1 105 ? 28.84325  -7.94324  -5.37674  1.000 15.56231 ? 141 ASN A ND2 1 
ATOM   815  N  N   . TYR A 1 106 ? 30.87585  -3.84103  -1.38147  1.000 17.66315 ? 142 TYR A N   1 
ATOM   816  C  CA  . TYR A 1 106 ? 31.96162  -3.17638  -0.63001  1.000 17.63536 ? 142 TYR A CA  1 
ATOM   817  C  C   . TYR A 1 106 ? 32.85835  -4.16125  0.10086   1.000 19.47975 ? 142 TYR A C   1 
ATOM   818  O  O   . TYR A 1 106 ? 32.38181  -5.01852  0.83655   1.000 18.86937 ? 142 TYR A O   1 
ATOM   819  C  CB  . TYR A 1 106 ? 31.36051  -2.25836  0.41686   1.000 21.15425 ? 142 TYR A CB  1 
ATOM   820  C  CG  . TYR A 1 106 ? 32.33571  -1.26790  1.06433   1.000 24.37690 ? 142 TYR A CG  1 
ATOM   821  C  CD1 . TYR A 1 106 ? 33.06283  -0.36444  0.29450   1.000 25.28609 ? 142 TYR A CD1 1 
ATOM   822  C  CD2 . TYR A 1 106 ? 32.50141  -1.24857  2.44520   1.000 27.43605 ? 142 TYR A CD2 1 
ATOM   823  C  CE1 . TYR A 1 106 ? 33.91809  0.57980   0.90316   1.000 29.83229 ? 142 TYR A CE1 1 
ATOM   824  C  CE2 . TYR A 1 106 ? 33.34610  -0.29326  3.06238   1.000 29.59067 ? 142 TYR A CE2 1 
ATOM   825  C  CZ  . TYR A 1 106 ? 34.05564  0.57901   2.26851   1.000 28.27779 ? 142 TYR A CZ  1 
ATOM   826  O  OH  . TYR A 1 106 ? 34.89174  1.49890   2.84082   1.000 39.42162 ? 142 TYR A OH  1 
ATOM   827  N  N   . GLU A 1 107 ? 34.16806  -3.98338  -0.06825  1.000 21.37767 ? 143 GLU A N   1 
ATOM   828  C  CA  . GLU A 1 107 ? 35.16006  -4.79296  0.64632   1.000 24.06279 ? 143 GLU A CA  1 
ATOM   829  C  C   . GLU A 1 107 ? 34.96653  -6.28312  0.40542   1.000 20.03240 ? 143 GLU A C   1 
ATOM   830  O  O   . GLU A 1 107 ? 35.31798  -7.10662  1.25225   1.000 22.78730 ? 143 GLU A O   1 
ATOM   831  C  CB  . GLU A 1 107 ? 35.11963  -4.48610  2.15752   1.000 28.87184 ? 143 GLU A CB  1 
ATOM   832  C  CG  . GLU A 1 107 ? 35.61633  -3.08115  2.48249   1.000 32.93522 ? 143 GLU A CG  1 
ATOM   833  C  CD  . GLU A 1 107 ? 35.85341  -2.91531  3.96374   1.000 35.39423 ? 143 GLU A CD  1 
ATOM   834  O  OE1 . GLU A 1 107 ? 34.89817  -3.09049  4.76148   1.000 37.73041 ? 143 GLU A OE1 1 
ATOM   835  O  OE2 . GLU A 1 107 ? 37.00199  -2.66270  4.33795   1.000 40.02710 ? 143 GLU A OE2 1 
ATOM   836  N  N   . GLY A 1 108 ? 34.34533  -6.66251  -0.71730  1.000 20.44764 ? 144 GLY A N   1 
ATOM   837  C  CA  . GLY A 1 108 ? 34.12882  -8.08094  -1.05580  1.000 19.94741 ? 144 GLY A CA  1 
ATOM   838  C  C   . GLY A 1 108 ? 33.01787  -8.78520  -0.29845  1.000 23.47959 ? 144 GLY A C   1 
ATOM   839  O  O   . GLY A 1 108 ? 32.92266  -10.03218 -0.36855  1.000 23.86512 ? 144 GLY A O   1 
ATOM   840  N  N   . ARG A 1 109 ? 32.17659  -8.03707  0.41895   1.000 23.37444 ? 145 ARG A N   1 
ATOM   841  C  CA  . ARG A 1 109 ? 31.01658  -8.58750  1.11778   1.000 23.12764 ? 145 ARG A CA  1 
ATOM   842  C  C   . ARG A 1 109 ? 29.84441  -8.74223  0.17718   1.000 18.64266 ? 145 ARG A C   1 
ATOM   843  O  O   . ARG A 1 109 ? 29.69192  -7.98333  -0.78242  1.000 19.81020 ? 145 ARG A O   1 
ATOM   844  C  CB  . ARG A 1 109 ? 30.56030  -7.67984  2.27707   1.000 25.81285 ? 145 ARG A CB  1 
ATOM   845  C  CG  . ARG A 1 109 ? 31.73140  -7.27245  3.15118   1.000 39.00673 ? 145 ARG A CG  1 
ATOM   846  C  CD  . ARG A 1 109 ? 31.41532  -6.46779  4.39486   1.000 51.33907 ? 145 ARG A CD  1 
ATOM   847  N  NE  . ARG A 1 109 ? 30.79167  -5.18293  4.11400   1.000 62.23205 ? 145 ARG A NE  1 
ATOM   848  C  CZ  . ARG A 1 109 ? 30.62000  -4.23429  5.02656   1.000 63.96910 ? 145 ARG A CZ  1 
ATOM   849  N  NH1 . ARG A 1 109 ? 31.05756  -4.37797  6.26307   1.000 56.94957 ? 145 ARG A NH1 1 
ATOM   850  N  NH2 . ARG A 1 109 ? 30.00691  -3.11033  4.68705   1.000 68.08004 ? 145 ARG A NH2 1 
ATOM   851  N  N   . GLN A 1 110 ? 28.96607  -9.66553  0.52352   1.000 20.52868 ? 146 GLN A N   1 
ATOM   852  C  CA  . GLN A 1 110 ? 27.76971  -9.89846  -0.26399  1.000 20.94212 ? 146 GLN A CA  1 
ATOM   853  C  C   . GLN A 1 110 ? 26.72217  -8.85275  0.04641   1.000 20.49954 ? 146 GLN A C   1 
ATOM   854  O  O   . GLN A 1 110 ? 26.01743  -8.95244  1.05326   1.000 19.76782 ? 146 GLN A O   1 
ATOM   855  C  CB  . GLN A 1 110 ? 27.22126  -11.26750 0.04395   1.000 20.93078 ? 146 GLN A CB  1 
ATOM   856  C  CG  . GLN A 1 110 ? 26.04096  -11.60690 -0.78831  1.000 27.02205 ? 146 GLN A CG  1 
ATOM   857  C  CD  . GLN A 1 110 ? 26.37947  -12.61086 -1.92479  1.000 54.84749 ? 146 GLN A CD  1 
ATOM   858  O  OE1 . GLN A 1 110 ? 26.57867  -12.23778 -3.12809  1.000 28.74761 ? 146 GLN A OE1 1 
ATOM   859  N  NE2 . GLN A 1 110 ? 26.53369  -13.88003 -1.52884  1.000 46.87988 ? 146 GLN A NE2 1 
ATOM   860  N  N   . GLU A 1 111 ? 26.60097  -7.85617  -0.80538  1.000 16.00510 ? 147 GLU A N   1 
ATOM   861  C  CA  . GLU A 1 111 ? 25.67441  -6.76416  -0.53730  1.000 13.86181 ? 147 GLU A CA  1 
ATOM   862  C  C   . GLU A 1 111 ? 24.46169  -6.90146  -1.45327  1.000 13.81469 ? 147 GLU A C   1 
ATOM   863  O  O   . GLU A 1 111 ? 24.43997  -6.36660  -2.54131  1.000 13.23492 ? 147 GLU A O   1 
ATOM   864  C  CB  . GLU A 1 111 ? 26.34134  -5.38671  -0.62652  1.000 15.25089 ? 147 GLU A CB  1 
ATOM   865  C  CG  . GLU A 1 111 ? 27.55560  -5.19918  0.32997   1.000 14.36985 ? 147 GLU A CG  1 
ATOM   866  C  CD  . GLU A 1 111 ? 27.87195  -3.76032  0.47124   1.000 17.48756 ? 147 GLU A CD  1 
ATOM   867  O  OE1 . GLU A 1 111 ? 28.12257  -3.13217  -0.57093  1.000 16.05754 ? 147 GLU A OE1 1 
ATOM   868  O  OE2 . GLU A 1 111 ? 27.98463  -3.27151  1.62139   1.000 18.19475 ? 147 GLU A OE2 1 
ATOM   869  N  N   . GLN A 1 112 ? 23.47923  -7.71062  -1.01354  1.000 12.80774 ? 148 GLN A N   1 
ATOM   870  C  CA  . GLN A 1 112 ? 22.38943  -8.13858  -1.90376  1.000 15.16304 ? 148 GLN A CA  1 
ATOM   871  C  C   . GLN A 1 112 ? 21.10977  -7.34334  -1.74677  1.000 13.12702 ? 148 GLN A C   1 
ATOM   872  O  O   . GLN A 1 112 ? 20.21357  -7.48665  -2.57886  1.000 13.39686 ? 148 GLN A O   1 
ATOM   873  C  CB  . GLN A 1 112 ? 22.09372  -9.61185  -1.64457  1.000 17.22245 ? 148 GLN A CB  1 
ATOM   874  C  CG  . GLN A 1 112 ? 23.18518  -10.52260 -2.25440  1.000 17.86762 ? 148 GLN A CG  1 
ATOM   875  C  CD  . GLN A 1 112 ? 23.12870  -11.91249 -1.69618  1.000 23.49880 ? 148 GLN A CD  1 
ATOM   876  O  OE1 . GLN A 1 112 ? 22.81517  -12.09476 -0.51020  1.000 27.63758 ? 148 GLN A OE1 1 
ATOM   877  N  NE2 . GLN A 1 112 ? 23.34304  -12.89590 -2.53920  1.000 23.85798 ? 148 GLN A NE2 1 
ATOM   878  N  N   . CYS A 1 113 ? 21.03968  -6.45795  -0.75504  1.000 14.09627 ? 149 CYS A N   1 
ATOM   879  C  CA  . CYS A 1 113 ? 19.78508  -5.78367  -0.42249  1.000 14.58674 ? 149 CYS A CA  1 
ATOM   880  C  C   . CYS A 1 113 ? 20.00904  -4.29181  -0.53290  1.000 12.60193 ? 149 CYS A C   1 
ATOM   881  O  O   . CYS A 1 113 ? 21.13878  -3.82158  -0.40738  1.000 14.80105 ? 149 CYS A O   1 
ATOM   882  C  CB  . CYS A 1 113 ? 19.33571  -6.13504  1.00651   1.000 13.02708 ? 149 CYS A CB  1 
ATOM   883  S  SG  . CYS A 1 113 ? 18.62067  -7.78251  1.02625   1.000 13.77019 ? 149 CYS A SG  1 
ATOM   884  N  N   . VAL A 1 114 ? 18.96167  -3.52386  -0.83554  1.000 12.76390 ? 150 VAL A N   1 
ATOM   885  C  CA  . VAL A 1 114 ? 19.20411  -2.10879  -1.17258  1.000 11.96827 ? 150 VAL A CA  1 
ATOM   886  C  C   . VAL A 1 114 ? 18.63263  -1.20663  -0.08431  1.000 13.17599 ? 150 VAL A C   1 
ATOM   887  O  O   . VAL A 1 114 ? 17.47165  -1.37717  0.32297   1.000 12.94639 ? 150 VAL A O   1 
ATOM   888  C  CB  . VAL A 1 114 ? 18.58542  -1.73590  -2.53179  1.000 12.55129 ? 150 VAL A CB  1 
ATOM   889  C  CG1 . VAL A 1 114 ? 18.80305  -0.26131  -2.78669  1.000 12.94009 ? 150 VAL A CG1 1 
ATOM   890  C  CG2 . VAL A 1 114 ? 19.33812  -2.54247  -3.61221  1.000 12.09121 ? 150 VAL A CG2 1 
ATOM   891  N  N   . GLU A 1 115 ? 19.44063  -0.26095  0.38826   1.000 12.64681 ? 151 GLU A N   1 
ATOM   892  C  CA  . GLU A 1 115 ? 18.94231  0.80344   1.25508   1.000 12.13600 ? 151 GLU A CA  1 
ATOM   893  C  C   . GLU A 1 115 ? 19.01978  2.15722   0.56066   1.000 12.70035 ? 151 GLU A C   1 
ATOM   894  O  O   . GLU A 1 115 ? 19.82944  2.38235   -0.34741  1.000 14.40055 ? 151 GLU A O   1 
ATOM   895  C  CB  . GLU A 1 115 ? 19.80368  0.85019   2.55006   1.000 13.04027 ? 151 GLU A CB  1 
ATOM   896  C  CG  . GLU A 1 115 ? 21.26248  1.32234   2.24062   1.000 14.41326 ? 151 GLU A CG  1 
ATOM   897  C  CD  . GLU A 1 115 ? 22.17670  1.39764   3.48900   1.000 16.60445 ? 151 GLU A CD  1 
ATOM   898  O  OE1 . GLU A 1 115 ? 21.71458  1.11435   4.62028   1.000 16.79764 ? 151 GLU A OE1 1 
ATOM   899  O  OE2 . GLU A 1 115 ? 23.35933  1.74076   3.30519   1.000 15.96469 ? 151 GLU A OE2 1 
ATOM   900  N  N   . GLN A 1 116 ? 18.20134  3.06318   1.00723   1.000 12.17522 ? 152 GLN A N   1 
ATOM   901  C  CA  . GLN A 1 116 ? 18.37468  4.48683   0.74118   1.000 14.83475 ? 152 GLN A CA  1 
ATOM   902  C  C   . GLN A 1 116 ? 19.24870  5.04147   1.86135   1.000 20.23921 ? 152 GLN A C   1 
ATOM   903  O  O   . GLN A 1 116 ? 18.92622  4.88797   3.03833   1.000 18.00652 ? 152 GLN A O   1 
ATOM   904  C  CB  . GLN A 1 116 ? 17.01398  5.19453   0.73034   1.000 14.20986 ? 152 GLN A CB  1 
ATOM   905  C  CG  . GLN A 1 116 ? 17.04016  6.77719   0.74318   1.000 15.47147 ? 152 GLN A CG  1 
ATOM   906  C  CD  . GLN A 1 116 ? 17.58284  7.33353   -0.55707  1.000 19.73757 ? 152 GLN A CD  1 
ATOM   907  O  OE1 . GLN A 1 116 ? 17.55395  6.66150   -1.59385  1.000 19.57277 ? 152 GLN A OE1 1 
ATOM   908  N  NE2 . GLN A 1 116 ? 18.13149  8.53655   -0.50548  1.000 20.70465 ? 152 GLN A NE2 1 
ATOM   909  N  N   . ILE A 1 117 ? 20.32587  5.69746   1.50647   1.000 18.81376 ? 153 ILE A N   1 
ATOM   910  C  CA  . ILE A 1 117 ? 21.25867  6.17456   2.52523   1.000 23.38426 ? 153 ILE A CA  1 
ATOM   911  C  C   . ILE A 1 117 ? 20.93228  7.60635   2.87386   1.000 29.49523 ? 153 ILE A C   1 
ATOM   912  O  O   . ILE A 1 117 ? 20.28170  8.33997   2.11500   1.000 31.50213 ? 153 ILE A O   1 
ATOM   913  C  CB  . ILE A 1 117 ? 22.71358  6.03605   2.09059   1.000 30.05850 ? 153 ILE A CB  1 
ATOM   914  C  CG1 . ILE A 1 117 ? 23.03678  7.14004   1.09240   1.000 35.12796 ? 153 ILE A CG1 1 
ATOM   915  C  CG2 . ILE A 1 117 ? 22.97693  4.67478   1.56436   1.000 29.03537 ? 153 ILE A CG2 1 
ATOM   916  C  CD1 . ILE A 1 117 ? 24.33030  6.88769   0.34798   1.000 41.58677 ? 153 ILE A CD1 1 
ATOM   917  N  N   . ASP A 1 118 ? 21.39827  8.00617   4.04789   1.000 28.43988 ? 154 ASP A N   1 
ATOM   918  C  CA  . ASP A 1 118 ? 21.27094  9.37614   4.54436   1.000 32.58757 ? 154 ASP A CA  1 
ATOM   919  C  C   . ASP A 1 118 ? 22.67033  9.82095   4.95379   1.000 38.17372 ? 154 ASP A C   1 
ATOM   920  O  O   . ASP A 1 118 ? 23.08530  9.57923   6.08875   1.000 37.92028 ? 154 ASP A O   1 
ATOM   921  C  CB  . ASP A 1 118 ? 20.27746  9.40680   5.72054   1.000 31.26982 ? 154 ASP A CB  1 
ATOM   922  C  CG  . ASP A 1 118 ? 20.41476  10.66097  6.58012   1.000 38.95366 ? 154 ASP A CG  1 
ATOM   923  O  OD1 . ASP A 1 118 ? 20.28319  11.74172  5.97703   1.000 35.16993 ? 154 ASP A OD1 1 
ATOM   924  O  OD2 . ASP A 1 118 ? 20.59965  10.54512  7.83853   1.000 35.45607 ? 154 ASP A OD2 1 
ATOM   925  N  N   . ARG A 1 119 ? 23.42948  10.39512  4.02716   1.000 39.22336 ? 155 ARG A N   1 
ATOM   926  C  CA  . ARG A 1 119 ? 24.81380  10.72997  4.33787   1.000 49.75868 ? 155 ARG A CA  1 
ATOM   927  C  C   . ARG A 1 119 ? 25.13324  12.11869  3.81888   1.000 53.97881 ? 155 ARG A C   1 
ATOM   928  O  O   . ARG A 1 119 ? 24.53258  12.59844  2.85019   1.000 50.46075 ? 155 ARG A O   1 
ATOM   929  C  CB  . ARG A 1 119 ? 25.81687  9.71350   3.75434   1.000 52.69890 ? 155 ARG A CB  1 
ATOM   930  C  CG  . ARG A 1 119 ? 25.79056  8.34602   4.42526   1.000 54.08677 ? 155 ARG A CG  1 
ATOM   931  C  CD  . ARG A 1 119 ? 26.74739  7.38987   3.72362   1.000 61.86675 ? 155 ARG A CD  1 
ATOM   932  N  NE  . ARG A 1 119 ? 28.14772  7.78226   3.84819   1.000 65.53131 ? 155 ARG A NE  1 
ATOM   933  C  CZ  . ARG A 1 119 ? 28.99642  7.25880   4.72568   1.000 68.86602 ? 155 ARG A CZ  1 
ATOM   934  N  NH1 . ARG A 1 119 ? 28.63399  6.26873   5.53274   1.000 65.64691 ? 155 ARG A NH1 1 
ATOM   935  N  NH2 . ARG A 1 119 ? 30.23805  7.74316   4.79932   1.000 66.13695 ? 155 ARG A NH2 1 
ATOM   936  N  N   . GLU A 1 120 ? 26.07540  12.76877  4.49710   1.000 57.61055 ? 156 GLU A N   1 
ATOM   937  C  CA  . GLU A 1 120 ? 26.57873  14.04430  4.02080   1.000 62.52056 ? 156 GLU A CA  1 
ATOM   938  C  C   . GLU A 1 120 ? 27.34895  13.80852  2.72679   1.000 63.48562 ? 156 GLU A C   1 
ATOM   939  O  O   . GLU A 1 120 ? 28.27220  12.98317  2.68469   1.000 63.07596 ? 156 GLU A O   1 
ATOM   940  C  CB  . GLU A 1 120 ? 27.48203  14.67935  5.08060   1.000 68.45477 ? 156 GLU A CB  1 
ATOM   941  C  CG  . GLU A 1 120 ? 26.80583  15.06030  6.41342   1.000 66.15787 ? 156 GLU A CG  1 
ATOM   942  C  CD  . GLU A 1 120 ? 25.65922  16.06231  6.27663   1.000 66.79163 ? 156 GLU A CD  1 
ATOM   943  O  OE1 . GLU A 1 120 ? 25.78246  17.01570  5.46991   1.000 60.30837 ? 156 GLU A OE1 1 
ATOM   944  O  OE2 . GLU A 1 120 ? 24.64555  15.90879  7.00202   1.000 71.84455 ? 156 GLU A OE2 1 
ATOM   945  N  N   . ASP A 1 121 ? 26.95488  14.51849  1.66585   1.000 66.25843 ? 157 ASP A N   1 
ATOM   946  C  CA  . ASP A 1 121 ? 27.61010  14.44859  0.35417   1.000 70.96380 ? 157 ASP A CA  1 
ATOM   947  C  C   . ASP A 1 121 ? 27.48233  13.07531  -0.31550  1.000 68.67446 ? 157 ASP A C   1 
ATOM   948  O  O   . ASP A 1 121 ? 28.27920  12.74051  -1.19503  1.000 72.53082 ? 157 ASP A O   1 
ATOM   949  C  CB  . ASP A 1 121 ? 29.09925  14.83096  0.43735   1.000 75.24138 ? 157 ASP A CB  1 
ATOM   950  C  CG  . ASP A 1 121 ? 29.32844  16.25215  0.93316   1.000 72.79674 ? 157 ASP A CG  1 
ATOM   951  O  OD1 . ASP A 1 121 ? 28.35548  16.92331  1.34211   1.000 72.79699 ? 157 ASP A OD1 1 
ATOM   952  O  OD2 . ASP A 1 121 ? 30.49955  16.69200  0.91294   1.000 71.93197 ? 157 ASP A OD2 1 
ATOM   953  N  N   . LYS A 1 122 ? 26.51043  12.25118  0.08648   1.000 66.85871 ? 158 LYS A N   1 
ATOM   954  C  CA  . LYS A 1 122 ? 26.26411  10.97058  -0.58771  1.000 58.78663 ? 158 LYS A CA  1 
ATOM   955  C  C   . LYS A 1 122 ? 24.81523  10.58415  -0.29009  1.000 50.53069 ? 158 LYS A C   1 
ATOM   956  O  O   . LYS A 1 122 ? 24.52628  10.11548  0.81516   1.000 49.32928 ? 158 LYS A O   1 
ATOM   957  C  CB  . LYS A 1 122 ? 27.22489  9.88785   -0.10856  1.000 58.86228 ? 158 LYS A CB  1 
ATOM   958  C  CG  . LYS A 1 122 ? 27.56945  8.86571   -1.17693  1.000 57.59207 ? 158 LYS A CG  1 
ATOM   959  C  CD  . LYS A 1 122 ? 28.35111  7.66517   -0.63101  1.000 56.53349 ? 158 LYS A CD  1 
ATOM   960  C  CE  . LYS A 1 122 ? 28.05322  6.38220   -1.45235  1.000 42.58753 ? 158 LYS A CE  1 
ATOM   961  N  NZ  . LYS A 1 122 ? 27.58943  5.19574   -0.59627  1.000 37.78304 ? 158 LYS A NZ  1 
ATOM   962  N  N   . LYS A 1 123 ? 23.92067  10.77858  -1.26220  1.000 46.88724 ? 159 LYS A N   1 
ATOM   963  C  CA  . LYS A 1 123 ? 22.53807  10.33712  -1.10318  1.000 45.82938 ? 159 LYS A CA  1 
ATOM   964  C  C   . LYS A 1 123 ? 22.12876  9.47880   -2.29792  1.000 38.04930 ? 159 LYS A C   1 
ATOM   965  O  O   . LYS A 1 123 ? 22.76257  9.51897   -3.35413  1.000 38.91182 ? 159 LYS A O   1 
ATOM   966  C  CB  . LYS A 1 123 ? 21.58764  11.53409  -0.89103  1.000 44.70805 ? 159 LYS A CB  1 
ATOM   967  C  CG  . LYS A 1 123 ? 21.96066  12.24191  0.42296   1.000 53.60901 ? 159 LYS A CG  1 
ATOM   968  C  CD  . LYS A 1 123 ? 21.04538  13.38303  0.89469   1.000 57.89930 ? 159 LYS A CD  1 
ATOM   969  C  CE  . LYS A 1 123 ? 21.63931  13.96643  2.21251   1.000 58.03882 ? 159 LYS A CE  1 
ATOM   970  N  NZ  . LYS A 1 123 ? 20.83780  15.04713  2.84545   1.000 65.10640 ? 159 LYS A NZ  1 
ATOM   971  N  N   . GLY A 1 124 ? 21.08676  8.66040   -2.10837  1.000 30.34369 ? 160 GLY A N   1 
ATOM   972  C  CA  . GLY A 1 124 ? 20.68306  7.68770   -3.11057  1.000 21.24651 ? 160 GLY A CA  1 
ATOM   973  C  C   . GLY A 1 124 ? 20.88229  6.28976   -2.56865  1.000 20.14417 ? 160 GLY A C   1 
ATOM   974  O  O   . GLY A 1 124 ? 21.14513  6.07694   -1.37553  1.000 18.76610 ? 160 GLY A O   1 
ATOM   975  N  N   . TRP A 1 125 ? 20.76951  5.31000   -3.47008  1.000 18.47408 ? 161 TRP A N   1 
ATOM   976  C  CA  . TRP A 1 125 ? 20.71489  3.93442   -2.99900  1.000 13.15491 ? 161 TRP A CA  1 
ATOM   977  C  C   . TRP A 1 125 ? 22.10710  3.34297   -2.81238  1.000 16.53793 ? 161 TRP A C   1 
ATOM   978  O  O   . TRP A 1 125 ? 23.08875  3.76251   -3.44752  1.000 17.07986 ? 161 TRP A O   1 
ATOM   979  C  CB  . TRP A 1 125 ? 20.01813  3.03596   -4.00711  1.000 12.55021 ? 161 TRP A CB  1 
ATOM   980  C  CG  . TRP A 1 125 ? 18.63865  3.51238   -4.47966  1.000 13.26492 ? 161 TRP A CG  1 
ATOM   981  C  CD1 . TRP A 1 125 ? 17.78829  4.41088   -3.88601  1.000 12.90108 ? 161 TRP A CD1 1 
ATOM   982  C  CD2 . TRP A 1 125 ? 17.98889  3.03167   -5.66453  1.000 13.92032 ? 161 TRP A CD2 1 
ATOM   983  N  NE1 . TRP A 1 125 ? 16.58561  4.48905   -4.65583  1.000 11.95345 ? 161 TRP A NE1 1 
ATOM   984  C  CE2 . TRP A 1 125 ? 16.72636  3.65590   -5.74963  1.000 13.75955 ? 161 TRP A CE2 1 
ATOM   985  C  CE3 . TRP A 1 125 ? 18.35278  2.09311   -6.64193  1.000 14.90903 ? 161 TRP A CE3 1 
ATOM   986  C  CZ2 . TRP A 1 125 ? 15.85449  3.37713   -6.78435  1.000 13.73597 ? 161 TRP A CZ2 1 
ATOM   987  C  CZ3 . TRP A 1 125 ? 17.50360  1.84563   -7.69193  1.000 11.88505 ? 161 TRP A CZ3 1 
ATOM   988  C  CH2 . TRP A 1 125 ? 16.27217  2.49940   -7.76045  1.000 13.72625 ? 161 TRP A CH2 1 
ATOM   989  N  N   . ASN A 1 126 ? 22.16064  2.30344   -1.97600  1.000 12.89436 ? 162 ASN A N   1 
ATOM   990  C  CA  . ASN A 1 126 ? 23.41850  1.63110   -1.65317  1.000 14.32966 ? 162 ASN A CA  1 
ATOM   991  C  C   . ASN A 1 126 ? 23.08665  0.15186   -1.49878  1.000 13.50475 ? 162 ASN A C   1 
ATOM   992  O  O   . ASN A 1 126 ? 22.05714  -0.19240  -0.87387  1.000 12.16913 ? 162 ASN A O   1 
ATOM   993  C  CB  . ASN A 1 126 ? 24.04987  2.17667   -0.35112  1.000 15.09314 ? 162 ASN A CB  1 
ATOM   994  C  CG  . ASN A 1 126 ? 25.21138  1.30177   0.11981   1.000 15.60555 ? 162 ASN A CG  1 
ATOM   995  O  OD1 . ASN A 1 126 ? 26.12059  0.98863   -0.69331  1.000 15.25342 ? 162 ASN A OD1 1 
ATOM   996  N  ND2 . ASN A 1 126 ? 25.20757  0.90596   1.40846   1.000 14.11618 ? 162 ASN A ND2 1 
ATOM   997  N  N   . ASP A 1 127 ? 23.87773  -0.71796  -2.13373  1.000 11.17557 ? 163 ASP A N   1 
ATOM   998  C  CA  . ASP A 1 127 ? 23.73779  -2.13296  -1.78573  1.000 12.02516 ? 163 ASP A CA  1 
ATOM   999  C  C   . ASP A 1 127 ? 24.41904  -2.41807  -0.44378  1.000 14.29785 ? 163 ASP A C   1 
ATOM   1000 O  O   . ASP A 1 127 ? 25.51433  -1.88715  -0.14316  1.000 13.04019 ? 163 ASP A O   1 
ATOM   1001 C  CB  . ASP A 1 127 ? 24.28099  -3.06365  -2.90353  1.000 12.42565 ? 163 ASP A CB  1 
ATOM   1002 C  CG  . ASP A 1 127 ? 25.79064  -2.83833  -3.22645  1.000 13.62342 ? 163 ASP A CG  1 
ATOM   1003 O  OD1 . ASP A 1 127 ? 26.30870  -1.71281  -3.04409  1.000 14.45021 ? 163 ASP A OD1 1 
ATOM   1004 O  OD2 . ASP A 1 127 ? 26.42136  -3.78106  -3.73087  1.000 11.51191 ? 163 ASP A OD2 1 
ATOM   1005 N  N   . LEU A 1 128 ? 23.73968  -3.23361  0.37980   1.000 13.18777 ? 164 LEU A N   1 
ATOM   1006 C  CA  . LEU A 1 128 ? 24.18920  -3.54617  1.74603   1.000 14.72748 ? 164 LEU A CA  1 
ATOM   1007 C  C   . LEU A 1 128 ? 23.92458  -5.01363  2.09296   1.000 14.87229 ? 164 LEU A C   1 
ATOM   1008 O  O   . LEU A 1 128 ? 23.04047  -5.64521  1.53835   1.000 14.49256 ? 164 LEU A O   1 
ATOM   1009 C  CB  . LEU A 1 128 ? 23.42872  -2.65242  2.77210   1.000 15.22311 ? 164 LEU A CB  1 
ATOM   1010 C  CG  . LEU A 1 128 ? 24.03860  -2.58043  4.16796   1.000 17.66964 ? 164 LEU A CG  1 
ATOM   1011 C  CD1 . LEU A 1 128 ? 25.37076  -1.94881  3.97513   1.000 18.02850 ? 164 LEU A CD1 1 
ATOM   1012 C  CD2 . LEU A 1 128 ? 23.13056  -1.76964  5.13036   1.000 16.91218 ? 164 LEU A CD2 1 
ATOM   1013 N  N   . VAL A 1 129 ? 24.72806  -5.56399  3.02147   1.000 15.79884 ? 165 VAL A N   1 
ATOM   1014 C  CA  . VAL A 1 129 ? 24.45732  -6.90797  3.55578   1.000 13.88970 ? 165 VAL A CA  1 
ATOM   1015 C  C   . VAL A 1 129 ? 23.00767  -7.00336  4.06757   1.000 17.31224 ? 165 VAL A C   1 
ATOM   1016 O  O   . VAL A 1 129 ? 22.54461  -6.15921  4.85946   1.000 14.45042 ? 165 VAL A O   1 
ATOM   1017 C  CB  . VAL A 1 129 ? 25.44422  -7.20930  4.68494   1.000 17.00679 ? 165 VAL A CB  1 
ATOM   1018 C  CG1 . VAL A 1 129 ? 25.15818  -8.58962  5.20416   1.000 17.23010 ? 165 VAL A CG1 1 
ATOM   1019 C  CG2 . VAL A 1 129 ? 26.86055  -7.09742  4.14264   1.000 20.66603 ? 165 VAL A CG2 1 
ATOM   1020 N  N   . CYS A 1 130 ? 22.28762  -8.04488  3.64389   1.000 15.24378 ? 166 CYS A N   1 
ATOM   1021 C  CA  . CYS A 1 130 ? 20.85468  -8.10834  3.99588   1.000 14.47593 ? 166 CYS A CA  1 
ATOM   1022 C  C   . CYS A 1 130 ? 20.64670  -8.32634  5.47542   1.000 15.19681 ? 166 CYS A C   1 
ATOM   1023 O  O   . CYS A 1 130 ? 19.58137  -8.00030  5.98843   1.000 15.33719 ? 166 CYS A O   1 
ATOM   1024 C  CB  . CYS A 1 130 ? 20.12215  -9.22376  3.27740   1.000 14.34722 ? 166 CYS A CB  1 
ATOM   1025 S  SG  . CYS A 1 130 ? 20.25610  -9.05313  1.44737   1.000 17.33112 ? 166 CYS A SG  1 
ATOM   1026 N  N   . GLU A 1 131 ? 21.64555  -8.87255  6.16722   1.000 18.80167 ? 167 GLU A N   1 
ATOM   1027 C  CA  . GLU A 1 131 ? 21.50465  -9.16786  7.59506   1.000 20.20159 ? 167 GLU A CA  1 
ATOM   1028 C  C   . GLU A 1 131 ? 21.84729  -7.98061  8.48112   1.000 19.20045 ? 167 GLU A C   1 
ATOM   1029 O  O   . GLU A 1 131 ? 21.64020  -8.07508  9.70421   1.000 18.09127 ? 167 GLU A O   1 
ATOM   1030 C  CB  . GLU A 1 131 ? 22.41451  -10.37041 7.93783   1.000 19.62005 ? 167 GLU A CB  1 
ATOM   1031 C  CG  . GLU A 1 131 ? 21.91270  -11.67968 7.35099   1.000 24.03825 ? 167 GLU A CG  1 
ATOM   1032 C  CD  . GLU A 1 131 ? 22.03197  -11.77690 5.77977   1.000 28.09137 ? 167 GLU A CD  1 
ATOM   1033 O  OE1 . GLU A 1 131 ? 23.02243  -11.28452 5.09322   1.000 22.67976 ? 167 GLU A OE1 1 
ATOM   1034 O  OE2 . GLU A 1 131 ? 21.10625  -12.42987 5.21768   1.000 38.94506 ? 167 GLU A OE2 1 
ATOM   1035 N  N   . PHE A 1 132 ? 22.28053  -6.85075  7.90951   1.000 16.39232 ? 168 PHE A N   1 
ATOM   1036 C  CA  . PHE A 1 132 ? 22.40949  -5.61707  8.68345   1.000 18.03306 ? 168 PHE A CA  1 
ATOM   1037 C  C   . PHE A 1 132 ? 21.02144  -5.02084  8.94040   1.000 14.83314 ? 168 PHE A C   1 
ATOM   1038 O  O   . PHE A 1 132 ? 20.04949  -5.40109  8.29622   1.000 15.37675 ? 168 PHE A O   1 
ATOM   1039 C  CB  . PHE A 1 132 ? 23.25472  -4.57171  7.94357   1.000 20.59622 ? 168 PHE A CB  1 
ATOM   1040 C  CG  . PHE A 1 132 ? 24.72978  -4.93422  7.80617   1.000 24.67289 ? 168 PHE A CG  1 
ATOM   1041 C  CD1 . PHE A 1 132 ? 25.21440  -6.16038  8.27329   1.000 23.55967 ? 168 PHE A CD1 1 
ATOM   1042 C  CD2 . PHE A 1 132 ? 25.63781  -4.02451  7.22695   1.000 27.93934 ? 168 PHE A CD2 1 
ATOM   1043 C  CE1 . PHE A 1 132 ? 26.58639  -6.49221  8.12311   1.000 22.40886 ? 168 PHE A CE1 1 
ATOM   1044 C  CE2 . PHE A 1 132 ? 27.02788  -4.34329  7.08027   1.000 26.08816 ? 168 PHE A CE2 1 
ATOM   1045 C  CZ  . PHE A 1 132 ? 27.48612  -5.57795  7.51600   1.000 27.09054 ? 168 PHE A CZ  1 
ATOM   1046 N  N   . SER A 1 133 ? 20.93065  -4.05192  9.88193   1.000 17.81045 ? 169 SER A N   1 
ATOM   1047 C  CA  . SER A 1 133 ? 19.60976  -3.55110  10.25086  1.000 15.62512 ? 169 SER A CA  1 
ATOM   1048 C  C   . SER A 1 133 ? 19.41015  -2.08471  9.88389   1.000 14.62894 ? 169 SER A C   1 
ATOM   1049 O  O   . SER A 1 133 ? 20.32731  -1.26195  10.00991  1.000 16.19431 ? 169 SER A O   1 
ATOM   1050 C  CB  . SER A 1 133 ? 19.35443  -3.75195  11.77663  1.000 15.47094 ? 169 SER A CB  1 
ATOM   1051 O  OG  . SER A 1 133 ? 18.98954  -5.12878  12.01797  1.000 17.50550 ? 169 SER A OG  1 
ATOM   1052 N  N   . ASN A 1 134 ? 18.20953  -1.75162  9.42981   1.000 12.22712 ? 170 ASN A N   1 
ATOM   1053 C  CA  . ASN A 1 134 ? 17.86660  -0.36244  9.13063   1.000 11.94479 ? 170 ASN A CA  1 
ATOM   1054 C  C   . ASN A 1 134 ? 16.38677  -0.19546  9.47391   1.000 12.59140 ? 170 ASN A C   1 
ATOM   1055 O  O   . ASN A 1 134 ? 15.64511  -1.17466  9.54107   1.000 12.77838 ? 170 ASN A O   1 
ATOM   1056 C  CB  . ASN A 1 134 ? 18.00051  -0.03488  7.63071   1.000 11.14755 ? 170 ASN A CB  1 
ATOM   1057 C  CG  . ASN A 1 134 ? 19.42086  0.20088   7.19468   1.000 12.60943 ? 170 ASN A CG  1 
ATOM   1058 O  OD1 . ASN A 1 134 ? 20.10774  1.02791   7.77262   1.000 17.52023 ? 170 ASN A OD1 1 
ATOM   1059 N  ND2 . ASN A 1 134 ? 19.81003  -0.40039  6.07213   1.000 16.51752 ? 170 ASN A ND2 1 
ATOM   1060 N  N   . PHE A 1 135 ? 15.98306  1.04834   9.72708   1.000 13.24044 ? 171 PHE A N   1 
ATOM   1061 C  CA  . PHE A 1 135 ? 14.58087  1.37837   9.58871   1.000 13.47699 ? 171 PHE A CA  1 
ATOM   1062 C  C   . PHE A 1 135 ? 14.13367  1.00605   8.17777   1.000 13.11437 ? 171 PHE A C   1 
ATOM   1063 O  O   . PHE A 1 135 ? 14.95616  0.84613   7.27118   1.000 14.41844 ? 171 PHE A O   1 
ATOM   1064 C  CB  . PHE A 1 135 ? 14.37383  2.89163   9.79138   1.000 13.59927 ? 171 PHE A CB  1 
ATOM   1065 C  CG  . PHE A 1 135 ? 14.70938  3.33634   11.20850  1.000 15.51385 ? 171 PHE A CG  1 
ATOM   1066 C  CD1 . PHE A 1 135 ? 14.02609  2.75238   12.26829  1.000 14.55019 ? 171 PHE A CD1 1 
ATOM   1067 C  CD2 . PHE A 1 135 ? 15.67180  4.30386   11.44133  1.000 17.05365 ? 171 PHE A CD2 1 
ATOM   1068 C  CE1 . PHE A 1 135 ? 14.27559  3.12260   13.60278  1.000 17.64368 ? 171 PHE A CE1 1 
ATOM   1069 C  CE2 . PHE A 1 135 ? 16.01053  4.65995   12.79221  1.000 17.93582 ? 171 PHE A CE2 1 
ATOM   1070 C  CZ  . PHE A 1 135 ? 15.26490  4.05968   13.86705  1.000 18.11482 ? 171 PHE A CZ  1 
ATOM   1071 N  N   . TYR A 1 136 ? 12.80847  0.87350   7.99191   1.000 12.48062 ? 172 TYR A N   1 
ATOM   1072 C  CA  . TYR A 1 136 ? 12.30731  0.40781   6.69583   1.000 11.75305 ? 172 TYR A CA  1 
ATOM   1073 C  C   . TYR A 1 136 ? 11.00748  1.12547   6.40675   1.000 13.54072 ? 172 TYR A C   1 
ATOM   1074 O  O   . TYR A 1 136 ? 10.34984  1.62107   7.30975   1.000 15.34881 ? 172 TYR A O   1 
ATOM   1075 C  CB  . TYR A 1 136 ? 12.10957  -1.15194  6.68564   1.000 11.81214 ? 172 TYR A CB  1 
ATOM   1076 C  CG  . TYR A 1 136 ? 11.30084  -1.73386  7.85323   1.000 13.18355 ? 172 TYR A CG  1 
ATOM   1077 C  CD1 . TYR A 1 136 ? 11.91994  -2.11104  9.04075   1.000 14.38842 ? 172 TYR A CD1 1 
ATOM   1078 C  CD2 . TYR A 1 136 ? 9.91677   -1.90537  7.73756   1.000 13.48040 ? 172 TYR A CD2 1 
ATOM   1079 C  CE1 . TYR A 1 136 ? 11.16944  -2.64499  10.11388  1.000 14.31947 ? 172 TYR A CE1 1 
ATOM   1080 C  CE2 . TYR A 1 136 ? 9.15388   -2.44419  8.76559   1.000 15.47932 ? 172 TYR A CE2 1 
ATOM   1081 C  CZ  . TYR A 1 136 ? 9.80221   -2.80347  9.96014   1.000 15.87480 ? 172 TYR A CZ  1 
ATOM   1082 O  OH  . TYR A 1 136 ? 9.09364   -3.31862  10.99280  1.000 18.59714 ? 172 TYR A OH  1 
ATOM   1083 N  N   . MET A 1 137 ? 10.63892  1.18137   5.11096   1.000 13.50161 ? 173 MET A N   1 
ATOM   1084 C  CA  A MET A 1 137 ? 9.44210   1.86793   4.63138   0.767 15.41601 ? 173 MET A CA  1 
ATOM   1085 C  CA  B MET A 1 137 ? 9.40070   1.82456   4.71139   0.233 15.37437 ? 173 MET A CA  1 
ATOM   1086 C  C   . MET A 1 137 ? 8.59400   0.85185   3.86434   1.000 15.86797 ? 173 MET A C   1 
ATOM   1087 O  O   . MET A 1 137 ? 9.11583   0.22444   2.91731   1.000 14.63323 ? 173 MET A O   1 
ATOM   1088 C  CB  A MET A 1 137 ? 9.81791   3.03101   3.69249   0.767 14.82859 ? 173 MET A CB  1 
ATOM   1089 C  CB  B MET A 1 137 ? 9.61862   3.14915   3.96068   0.233 15.29518 ? 173 MET A CB  1 
ATOM   1090 C  CG  A MET A 1 137 ? 8.52692   3.71862   2.99894   0.767 14.83032 ? 173 MET A CG  1 
ATOM   1091 C  CG  B MET A 1 137 ? 8.27936   3.95436   3.85192   0.233 14.94710 ? 173 MET A CG  1 
ATOM   1092 S  SD  A MET A 1 137 ? 9.08069   5.01656   1.92164   0.767 20.85191 ? 173 MET A SD  1 
ATOM   1093 S  SD  B MET A 1 137 ? 8.41626   5.63579   3.29107   0.233 17.93074 ? 173 MET A SD  1 
ATOM   1094 C  CE  A MET A 1 137 ? 9.06025   6.35427   3.14923   0.767 15.60965 ? 173 MET A CE  1 
ATOM   1095 C  CE  B MET A 1 137 ? 8.85422   5.32335   1.57603   0.233 17.94323 ? 173 MET A CE  1 
ATOM   1096 N  N   . CYS A 1 138 ? 7.34052   0.66936   4.28543   1.000 14.31973 ? 174 CYS A N   1 
ATOM   1097 C  CA  . CYS A 1 138 ? 6.36545   -0.14693  3.55807   1.000 12.32720 ? 174 CYS A CA  1 
ATOM   1098 C  C   . CYS A 1 138 ? 5.62998   0.77489   2.61140   1.000 15.14654 ? 174 CYS A C   1 
ATOM   1099 O  O   . CYS A 1 138 ? 5.50929   1.96337   2.89363   1.000 12.79802 ? 174 CYS A O   1 
ATOM   1100 C  CB  . CYS A 1 138 ? 5.32977   -0.74214  4.50677   1.000 14.47764 ? 174 CYS A CB  1 
ATOM   1101 S  SG  . CYS A 1 138 ? 6.07767   -1.73791  5.85952   1.000 16.16078 ? 174 CYS A SG  1 
ATOM   1102 N  N   . GLU A 1 139 ? 5.10124   0.20777   1.50553   1.000 12.39664 ? 175 GLU A N   1 
ATOM   1103 C  CA  . GLU A 1 139 ? 4.26097   0.94683   0.55468   1.000 12.15566 ? 175 GLU A CA  1 
ATOM   1104 C  C   . GLU A 1 139 ? 3.10022   0.02384   0.17303   1.000 13.23700 ? 175 GLU A C   1 
ATOM   1105 O  O   . GLU A 1 139 ? 3.32691   -1.15895  -0.12190  1.000 14.80142 ? 175 GLU A O   1 
ATOM   1106 C  CB  . GLU A 1 139 ? 5.01491   1.31947   -0.74331  1.000 12.73073 ? 175 GLU A CB  1 
ATOM   1107 C  CG  . GLU A 1 139 ? 4.06858   2.05327   -1.75535  1.000 12.81603 ? 175 GLU A CG  1 
ATOM   1108 C  CD  . GLU A 1 139 ? 4.77586   2.32899   -3.09293  1.000 13.16953 ? 175 GLU A CD  1 
ATOM   1109 O  OE1 . GLU A 1 139 ? 5.92753   1.90941   -3.32443  1.000 15.22302 ? 175 GLU A OE1 1 
ATOM   1110 O  OE2 . GLU A 1 139 ? 4.18694   3.00689   -3.92015  1.000 13.99946 ? 175 GLU A OE2 1 
ATOM   1111 N  N   . LYS A 1 140 ? 1.88325   0.57563   0.12631   1.000 15.35734 ? 176 LYS A N   1 
ATOM   1112 C  CA  . LYS A 1 140 ? 0.68824   -0.12659  -0.31785  1.000 13.56555 ? 176 LYS A CA  1 
ATOM   1113 C  C   . LYS A 1 140 ? 0.05728   0.75206   -1.39468  1.000 16.67833 ? 176 LYS A C   1 
ATOM   1114 O  O   . LYS A 1 140 ? -0.25889  1.91840   -1.12167  1.000 13.70303 ? 176 LYS A O   1 
ATOM   1115 C  CB  . LYS A 1 140 ? -0.23582  -0.33050  0.91445   1.000 16.56495 ? 176 LYS A CB  1 
ATOM   1116 C  CG  . LYS A 1 140 ? -1.59956  -0.92698  0.64864   1.000 20.74429 ? 176 LYS A CG  1 
ATOM   1117 C  CD  . LYS A 1 140 ? -2.45509  -0.99942  1.90552   1.000 21.77914 ? 176 LYS A CD  1 
ATOM   1118 C  CE  . LYS A 1 140 ? -1.95510  -2.06634  2.91649   1.000 24.18417 ? 176 LYS A CE  1 
ATOM   1119 N  NZ  . LYS A 1 140 ? -3.00042  -3.17960  3.09730   1.000 18.71071 ? 176 LYS A NZ  1 
ATOM   1120 N  N   . ARG A 1 141 ? -0.06547  0.24527   -2.63783  1.000 15.96616 ? 177 ARG A N   1 
ATOM   1121 C  CA  . ARG A 1 141 ? -0.81165  0.99754   -3.64337  1.000 17.93890 ? 177 ARG A CA  1 
ATOM   1122 C  C   . ARG A 1 141 ? -2.29407  0.94898   -3.31664  1.000 23.03936 ? 177 ARG A C   1 
ATOM   1123 O  O   . ARG A 1 141 ? -2.83727  -0.11369  -3.06115  1.000 21.03576 ? 177 ARG A O   1 
ATOM   1124 C  CB  . ARG A 1 141 ? -0.59343  0.41496   -5.04530  1.000 22.44944 ? 177 ARG A CB  1 
ATOM   1125 C  CG  . ARG A 1 141 ? 0.87626   0.44386   -5.40888  1.000 25.19903 ? 177 ARG A CG  1 
ATOM   1126 C  CD  . ARG A 1 141 ? 1.17179   0.04171   -6.87512  1.000 29.26745 ? 177 ARG A CD  1 
ATOM   1127 N  NE  . ARG A 1 141 ? 0.43672   0.86352   -7.84452  1.000 35.91858 ? 177 ARG A NE  1 
ATOM   1128 C  CZ  . ARG A 1 141 ? 0.23416   0.49275   -9.10547  1.000 41.06201 ? 177 ARG A CZ  1 
ATOM   1129 N  NH1 . ARG A 1 141 ? 0.77945   -0.61984  -9.59344  1.000 35.10565 ? 177 ARG A NH1 1 
ATOM   1130 N  NH2 . ARG A 1 141 ? -0.47231  1.28279   -9.91203  1.000 40.33937 ? 177 ARG A NH2 1 
ATOM   1131 N  N   . ILE A 1 142 ? -2.95015  2.09956   -3.28789  1.000 25.19134 ? 178 ILE A N   1 
ATOM   1132 C  CA  . ILE A 1 142 ? -4.36057  2.13977   -2.95340  1.000 27.72613 ? 178 ILE A CA  1 
ATOM   1133 C  C   . ILE A 1 142 ? -5.17445  2.32838   -4.21115  1.000 34.87289 ? 178 ILE A C   1 
ATOM   1134 O  O   . ILE A 1 142 ? -6.08451  1.54545   -4.49768  1.000 28.71537 ? 178 ILE A O   1 
ATOM   1135 C  CB  . ILE A 1 142 ? -4.65563  3.26316   -1.93162  1.000 27.63070 ? 178 ILE A CB  1 
ATOM   1136 C  CG1 . ILE A 1 142 ? -4.17164  2.89337   -0.55622  1.000 24.44485 ? 178 ILE A CG1 1 
ATOM   1137 C  CG2 . ILE A 1 142 ? -6.18528  3.41343   -1.75510  1.000 34.57169 ? 178 ILE A CG2 1 
ATOM   1138 C  CD1 . ILE A 1 142 ? -4.29860  1.44624   -0.19053  1.000 28.88578 ? 178 ILE A CD1 1 
ATOM   1139 N  N   . PHE A 1 143 ? -4.79122  3.35758   -5.03880  1.000 30.61954 ? 179 PHE A N   1 
ATOM   1140 C  CA  . PHE A 1 143 ? -5.48729  3.48137   -6.30748  1.000 36.76506 ? 179 PHE A CA  1 
ATOM   1141 C  C   . PHE A 1 143 ? -4.54851  3.20319   -7.46800  1.000 38.78830 ? 179 PHE A C   1 
ATOM   1142 O  O   . PHE A 1 143 ? -3.33964  3.43157   -7.37174  1.000 35.64282 ? 179 PHE A O   1 
ATOM   1143 C  CB  . PHE A 1 143 ? -6.11222  4.86648   -6.49190  1.000 39.39229 ? 179 PHE A CB  1 
ATOM   1144 C  CG  . PHE A 1 143 ? -6.73512  5.44145   -5.22749  1.000 43.64030 ? 179 PHE A CG  1 
ATOM   1145 C  CD1 . PHE A 1 143 ? -5.98624  6.16238   -4.31152  1.000 40.63334 ? 179 PHE A CD1 1 
ATOM   1146 C  CD2 . PHE A 1 143 ? -8.07149  5.18856   -4.92927  1.000 44.16781 ? 179 PHE A CD2 1 
ATOM   1147 C  CE1 . PHE A 1 143 ? -6.57747  6.67453   -3.15311  1.000 44.51157 ? 179 PHE A CE1 1 
ATOM   1148 C  CE2 . PHE A 1 143 ? -8.65578  5.68445   -3.77069  1.000 44.09169 ? 179 PHE A CE2 1 
ATOM   1149 C  CZ  . PHE A 1 143 ? -7.90142  6.43035   -2.88381  1.000 44.77034 ? 179 PHE A CZ  1 
ATOM   1150 N  N   . PRO A 1 144 ? -5.06004  2.68660   -8.58624  1.000 44.77895 ? 180 PRO A N   1 
ATOM   1151 C  CA  . PRO A 1 144 ? -4.15329  2.40590   -9.71586  1.000 43.78042 ? 180 PRO A CA  1 
ATOM   1152 C  C   . PRO A 1 144 ? -3.73776  3.65154   -10.50797 1.000 49.10921 ? 180 PRO A C   1 
ATOM   1153 O  O   . PRO A 1 144 ? -2.59997  3.65166   -11.00062 1.000 51.43429 ? 180 PRO A O   1 
ATOM   1154 C  CB  . PRO A 1 144 ? -4.97044  1.45702   -10.59430 1.000 42.94951 ? 180 PRO A CB  1 
ATOM   1155 C  CG  . PRO A 1 144 ? -6.39884  1.79293   -10.24864 1.000 46.60231 ? 180 PRO A CG  1 
ATOM   1156 C  CD  . PRO A 1 144 ? -6.42350  2.17240   -8.80256  1.000 46.16829 ? 180 PRO A CD  1 
ATOM   1157 N  N   . PHE B 1 11  ? -9.12421  14.54839  -4.66192  1.000 50.78380 ? 47  PHE E N   1 
ATOM   1158 C  CA  . PHE B 1 11  ? -7.67049  14.38325  -4.62191  1.000 47.75815 ? 47  PHE E CA  1 
ATOM   1159 C  C   . PHE B 1 11  ? -6.86525  15.06141  -5.70557  1.000 43.69420 ? 47  PHE E C   1 
ATOM   1160 O  O   . PHE B 1 11  ? -5.66296  15.24065  -5.49379  1.000 39.68355 ? 47  PHE E O   1 
ATOM   1161 C  CB  . PHE B 1 11  ? -7.21642  12.89120  -4.64554  1.000 54.07190 ? 47  PHE E CB  1 
ATOM   1162 C  CG  . PHE B 1 11  ? -7.57367  12.09138  -3.41685  1.000 56.01055 ? 47  PHE E CG  1 
ATOM   1163 C  CD1 . PHE B 1 11  ? -7.87345  12.72381  -2.21470  1.000 53.62297 ? 47  PHE E CD1 1 
ATOM   1164 C  CD2 . PHE B 1 11  ? -7.56275  10.69468  -3.45708  1.000 61.59975 ? 47  PHE E CD2 1 
ATOM   1165 C  CE1 . PHE B 1 11  ? -8.18215  11.98950  -1.05861  1.000 53.57037 ? 47  PHE E CE1 1 
ATOM   1166 C  CE2 . PHE B 1 11  ? -7.88278  9.94078   -2.31076  1.000 64.21107 ? 47  PHE E CE2 1 
ATOM   1167 C  CZ  . PHE B 1 11  ? -8.19508  10.59958  -1.10433  1.000 57.28974 ? 47  PHE E CZ  1 
ATOM   1168 N  N   . ASP B 1 12  ? -7.46176  15.39416  -6.86280  1.000 45.14167 ? 48  ASP E N   1 
ATOM   1169 C  CA  . ASP B 1 12  ? -6.67945  16.05361  -7.91180  1.000 43.22172 ? 48  ASP E CA  1 
ATOM   1170 C  C   . ASP B 1 12  ? -5.95620  17.27797  -7.39800  1.000 37.12637 ? 48  ASP E C   1 
ATOM   1171 O  O   . ASP B 1 12  ? -4.83372  17.51886  -7.82789  1.000 39.80190 ? 48  ASP E O   1 
ATOM   1172 C  CB  . ASP B 1 12  ? -7.53982  16.45436  -9.10654  1.000 47.44499 ? 48  ASP E CB  1 
ATOM   1173 C  CG  . ASP B 1 12  ? -7.99399  15.26356  -9.93030  1.000 59.38584 ? 48  ASP E CG  1 
ATOM   1174 O  OD1 . ASP B 1 12  ? -7.40958  14.16397  -9.75526  1.000 56.19791 ? 48  ASP E OD1 1 
ATOM   1175 O  OD2 . ASP B 1 12  ? -8.92452  15.43488  -10.75879 1.000 62.74480 ? 48  ASP E OD2 1 
ATOM   1176 N  N   . LYS B 1 13  ? -6.54279  18.03282  -6.45012  1.000 30.47628 ? 49  LYS E N   1 
ATOM   1177 C  CA  . LYS B 1 13  ? -5.87149  19.24794  -5.99042  1.000 31.11622 ? 49  LYS E CA  1 
ATOM   1178 C  C   . LYS B 1 13  ? -4.61061  18.94811  -5.16890  1.000 29.81021 ? 49  LYS E C   1 
ATOM   1179 O  O   . LYS B 1 13  ? -3.81083  19.86083  -4.96342  1.000 29.64615 ? 49  LYS E O   1 
ATOM   1180 C  CB  . LYS B 1 13  ? -6.80493  20.11939  -5.16013  1.000 30.38767 ? 49  LYS E CB  1 
ATOM   1181 C  CG  . LYS B 1 13  ? -7.44311  19.42984  -3.98658  1.000 30.86794 ? 49  LYS E CG  1 
ATOM   1182 C  CD  . LYS B 1 13  ? -8.18134  20.43040  -3.08387  1.000 30.33441 ? 49  LYS E CD  1 
ATOM   1183 C  CE  . LYS B 1 13  ? -9.18674  19.66094  -2.18732  1.000 32.15826 ? 49  LYS E CE  1 
ATOM   1184 N  NZ  . LYS B 1 13  ? -10.39829 19.14407  -2.90019  1.000 35.38839 ? 49  LYS E NZ  1 
ATOM   1185 N  N   . LEU B 1 14  ? -4.42830  17.70915  -4.65856  1.000 29.33656 ? 50  LEU E N   1 
ATOM   1186 C  CA  . LEU B 1 14  ? -3.16556  17.37919  -3.97539  1.000 27.62133 ? 50  LEU E CA  1 
ATOM   1187 C  C   . LEU B 1 14  ? -2.01436  17.19736  -4.94540  1.000 30.17514 ? 50  LEU E C   1 
ATOM   1188 O  O   . LEU B 1 14  ? -0.85792  17.35598  -4.54703  1.000 25.92354 ? 50  LEU E O   1 
ATOM   1189 C  CB  . LEU B 1 14  ? -3.29700  16.09805  -3.15524  1.000 23.78154 ? 50  LEU E CB  1 
ATOM   1190 C  CG  . LEU B 1 14  ? -4.51742  16.01900  -2.25121  1.000 23.93243 ? 50  LEU E CG  1 
ATOM   1191 C  CD1 . LEU B 1 14  ? -4.56825  14.68355  -1.55988  1.000 23.66442 ? 50  LEU E CD1 1 
ATOM   1192 C  CD2 . LEU B 1 14  ? -4.43023  17.12279  -1.21369  1.000 22.92571 ? 50  LEU E CD2 1 
ATOM   1193 N  N   . ASP B 1 15  ? -2.29002  16.83667  -6.20923  1.000 30.27943 ? 51  ASP E N   1 
ATOM   1194 C  CA  . ASP B 1 15  ? -1.19152  16.48128  -7.10326  1.000 31.80950 ? 51  ASP E CA  1 
ATOM   1195 C  C   . ASP B 1 15  ? -0.14639  17.57671  -7.26534  1.000 30.26834 ? 51  ASP E C   1 
ATOM   1196 O  O   . ASP B 1 15  ? 1.05538   17.24503  -7.28521  1.000 32.88408 ? 51  ASP E O   1 
ATOM   1197 C  CB  . ASP B 1 15  ? -1.70711  16.03617  -8.48390  1.000 31.58327 ? 51  ASP E CB  1 
ATOM   1198 C  CG  . ASP B 1 15  ? -2.54706  14.78071  -8.43233  1.000 43.04039 ? 51  ASP E CG  1 
ATOM   1199 O  OD1 . ASP B 1 15  ? -3.40544  14.59258  -9.33482  1.000 48.50226 ? 51  ASP E OD1 1 
ATOM   1200 O  OD2 . ASP B 1 15  ? -2.33374  13.95569  -7.51435  1.000 50.18492 ? 51  ASP E OD2 1 
ATOM   1201 N  N   . PRO B 1 16  ? -0.49015  18.85519  -7.42480  1.000 30.58526 ? 52  PRO E N   1 
ATOM   1202 C  CA  . PRO B 1 16  ? 0.58488   19.83510  -7.53556  1.000 28.69973 ? 52  PRO E CA  1 
ATOM   1203 C  C   . PRO B 1 16  ? 1.45958   19.84941  -6.30449  1.000 28.27749 ? 52  PRO E C   1 
ATOM   1204 O  O   . PRO B 1 16  ? 2.67308   20.06349  -6.40168  1.000 28.68256 ? 52  PRO E O   1 
ATOM   1205 C  CB  . PRO B 1 16  ? -0.16649  21.15405  -7.74288  1.000 31.20032 ? 52  PRO E CB  1 
ATOM   1206 C  CG  . PRO B 1 16  ? -1.46394  20.73939  -8.31949  1.000 34.79152 ? 52  PRO E CG  1 
ATOM   1207 C  CD  . PRO B 1 16  ? -1.81056  19.45623  -7.66886  1.000 32.43906 ? 52  PRO E CD  1 
ATOM   1208 N  N   . TYR B 1 17  ? 0.86420   19.61937  -5.13605  1.000 26.90043 ? 53  TYR E N   1 
ATOM   1209 C  CA  . TYR B 1 17  ? 1.63616   19.59710  -3.90972  1.000 24.41105 ? 53  TYR E CA  1 
ATOM   1210 C  C   . TYR B 1 17  ? 2.51198   18.35787  -3.85343  1.000 23.01914 ? 53  TYR E C   1 
ATOM   1211 O  O   . TYR B 1 17  ? 3.70116   18.43992  -3.47628  1.000 21.68817 ? 53  TYR E O   1 
ATOM   1212 C  CB  . TYR B 1 17  ? 0.70007   19.59372  -2.71397  1.000 24.23837 ? 53  TYR E CB  1 
ATOM   1213 C  CG  . TYR B 1 17  ? -0.01408  20.89223  -2.47921  1.000 28.77608 ? 53  TYR E CG  1 
ATOM   1214 C  CD1 . TYR B 1 17  ? 0.65947   22.00432  -1.95600  1.000 23.45252 ? 53  TYR E CD1 1 
ATOM   1215 C  CD2 . TYR B 1 17  ? -1.36579  21.00587  -2.78773  1.000 25.27905 ? 53  TYR E CD2 1 
ATOM   1216 C  CE1 . TYR B 1 17  ? -0.01487  23.20621  -1.75153  1.000 25.63524 ? 53  TYR E CE1 1 
ATOM   1217 C  CE2 . TYR B 1 17  ? -2.04797  22.21037  -2.58729  1.000 25.40931 ? 53  TYR E CE2 1 
ATOM   1218 C  CZ  . TYR B 1 17  ? -1.35752  23.28852  -2.06628  1.000 27.53251 ? 53  TYR E CZ  1 
ATOM   1219 O  OH  . TYR B 1 17  ? -2.06672  24.46351  -1.84311  1.000 27.43395 ? 53  TYR E OH  1 
ATOM   1220 N  N   . PHE B 1 18  ? 1.92755   17.19037  -4.18316  1.000 20.44735 ? 54  PHE E N   1 
ATOM   1221 C  CA  . PHE B 1 18  ? 2.73866   15.95450  -4.26681  1.000 20.15966 ? 54  PHE E CA  1 
ATOM   1222 C  C   . PHE B 1 18  ? 3.92734   16.12356  -5.23156  1.000 24.55989 ? 54  PHE E C   1 
ATOM   1223 O  O   . PHE B 1 18  ? 5.03057   15.60793  -4.98437  1.000 20.25776 ? 54  PHE E O   1 
ATOM   1224 C  CB  . PHE B 1 18  ? 1.91878   14.79201  -4.81652  1.000 19.41468 ? 54  PHE E CB  1 
ATOM   1225 C  CG  . PHE B 1 18  ? 0.87000   14.23377  -3.87638  1.000 18.82835 ? 54  PHE E CG  1 
ATOM   1226 C  CD1 . PHE B 1 18  ? 1.02808   14.27482  -2.47524  1.000 16.61168 ? 54  PHE E CD1 1 
ATOM   1227 C  CD2 . PHE B 1 18  ? -0.27651  13.63786  -4.42860  1.000 17.34958 ? 54  PHE E CD2 1 
ATOM   1228 C  CE1 . PHE B 1 18  ? 0.06662   13.74232  -1.63053  1.000 14.82664 ? 54  PHE E CE1 1 
ATOM   1229 C  CE2 . PHE B 1 18  ? -1.24565  13.06729  -3.59798  1.000 16.12497 ? 54  PHE E CE2 1 
ATOM   1230 C  CZ  . PHE B 1 18  ? -1.07165  13.14425  -2.16610  1.000 16.15463 ? 54  PHE E CZ  1 
ATOM   1231 N  N   . GLN B 1 19  ? 3.70611   16.77360  -6.37360  1.000 25.03947 ? 55  GLN E N   1 
ATOM   1232 C  CA  . GLN B 1 19  ? 4.84448   16.96182  -7.26822  1.000 27.83896 ? 55  GLN E CA  1 
ATOM   1233 C  C   . GLN B 1 19  ? 5.94534   17.82569  -6.65201  1.000 28.59525 ? 55  GLN E C   1 
ATOM   1234 O  O   . GLN B 1 19  ? 7.09572   17.69351  -7.07925  1.000 29.75210 ? 55  GLN E O   1 
ATOM   1235 C  CB  . GLN B 1 19  ? 4.40694   17.48615  -8.63665  1.000 31.66128 ? 55  GLN E CB  1 
ATOM   1236 C  CG  . GLN B 1 19  ? 3.75930   16.39938  -9.52315  1.000 33.89050 ? 55  GLN E CG  1 
ATOM   1237 C  CD  . GLN B 1 19  ? 4.84435   15.37759  -10.05059 1.000 44.64732 ? 55  GLN E CD  1 
ATOM   1238 O  OE1 . GLN B 1 19  ? 4.79195   14.16750  -9.78742  1.000 37.17861 ? 55  GLN E OE1 1 
ATOM   1239 N  NE2 . GLN B 1 19  ? 5.83371   15.89767  -10.78821 1.000 44.41323 ? 55  GLN E NE2 1 
ATOM   1240 N  N   . GLN B 1 20  ? 5.65847   18.58715  -5.58209  1.000 24.30388 ? 56  GLN E N   1 
ATOM   1241 C  CA  . GLN B 1 20  ? 6.67698   19.35249  -4.87868  1.000 24.46078 ? 56  GLN E CA  1 
ATOM   1242 C  C   . GLN B 1 20  ? 7.14825   18.67712  -3.58936  1.000 21.02229 ? 56  GLN E C   1 
ATOM   1243 O  O   . GLN B 1 20  ? 7.91014   19.28525  -2.82804  1.000 26.85086 ? 56  GLN E O   1 
ATOM   1244 C  CB  . GLN B 1 20  ? 6.13378   20.73632  -4.57677  1.000 28.06896 ? 56  GLN E CB  1 
ATOM   1245 C  CG  . GLN B 1 20  ? 6.09190   21.62598  -5.81186  1.000 34.88368 ? 56  GLN E CG  1 
ATOM   1246 C  CD  . GLN B 1 20  ? 5.67358   23.02554  -5.43211  1.000 43.80566 ? 56  GLN E CD  1 
ATOM   1247 O  OE1 . GLN B 1 20  ? 6.48107   23.96626  -5.42795  1.000 50.39385 ? 56  GLN E OE1 1 
ATOM   1248 N  NE2 . GLN B 1 20  ? 4.37544   23.18456  -5.15131  1.000 42.88970 ? 56  GLN E NE2 1 
ATOM   1249 N  N   . GLY B 1 21  ? 6.71283   17.45382  -3.30919  1.000 20.00044 ? 57  GLY E N   1 
ATOM   1250 C  CA  . GLY B 1 21  ? 7.22544   16.73121  -2.16508  1.000 17.08005 ? 57  GLY E CA  1 
ATOM   1251 C  C   . GLY B 1 21  ? 6.35861   16.80744  -0.91860  1.000 15.89202 ? 57  GLY E C   1 
ATOM   1252 O  O   . GLY B 1 21  ? 6.73790   16.26152  0.11272   1.000 19.48168 ? 57  GLY E O   1 
ATOM   1253 N  N   . TRP B 1 22  ? 5.21035   17.45302  -0.99135  1.000 16.57352 ? 58  TRP E N   1 
ATOM   1254 C  CA  . TRP B 1 22  ? 4.27241   17.43384  0.13766   1.000 16.76456 ? 58  TRP E CA  1 
ATOM   1255 C  C   . TRP B 1 22  ? 3.61796   16.08095  0.22404   1.000 14.47030 ? 58  TRP E C   1 
ATOM   1256 O  O   . TRP B 1 22  ? 3.52360   15.36677  -0.77831  1.000 18.50013 ? 58  TRP E O   1 
ATOM   1257 C  CB  . TRP B 1 22  ? 3.12773   18.44086  -0.04928  1.000 17.44088 ? 58  TRP E CB  1 
ATOM   1258 C  CG  . TRP B 1 22  ? 3.58062   19.86415  -0.02168  1.000 17.31690 ? 58  TRP E CG  1 
ATOM   1259 C  CD1 . TRP B 1 22  ? 4.27799   20.52533  -1.00384  1.000 21.64450 ? 58  TRP E CD1 1 
ATOM   1260 C  CD2 . TRP B 1 22  ? 3.32701   20.82272  1.01865   1.000 19.72315 ? 58  TRP E CD2 1 
ATOM   1261 N  NE1 . TRP B 1 22  ? 4.51980   21.81717  -0.60919  1.000 19.19072 ? 58  TRP E NE1 1 
ATOM   1262 C  CE2 . TRP B 1 22  ? 3.93957   22.03405  0.62311   1.000 19.57492 ? 58  TRP E CE2 1 
ATOM   1263 C  CE3 . TRP B 1 22  ? 2.67714   20.75980  2.26669   1.000 14.43037 ? 58  TRP E CE3 1 
ATOM   1264 C  CZ2 . TRP B 1 22  ? 3.88077   23.21301  1.41531   1.000 20.07352 ? 58  TRP E CZ2 1 
ATOM   1265 C  CZ3 . TRP B 1 22  ? 2.63060   21.90566  3.06950   1.000 15.07695 ? 58  TRP E CZ3 1 
ATOM   1266 C  CH2 . TRP B 1 22  ? 3.22783   23.12894  2.63405   1.000 16.09043 ? 58  TRP E CH2 1 
ATOM   1267 N  N   . PHE B 1 23  ? 3.12517   15.73649  1.40980   1.000 14.08810 ? 59  PHE E N   1 
ATOM   1268 C  CA  . PHE B 1 23  ? 2.40996   14.45945  1.53815   1.000 13.97096 ? 59  PHE E CA  1 
ATOM   1269 C  C   . PHE B 1 23  ? 1.22065   14.62269  2.47275   1.000 15.20161 ? 59  PHE E C   1 
ATOM   1270 O  O   . PHE B 1 23  ? 1.09519   15.60619  3.21678   1.000 15.10528 ? 59  PHE E O   1 
ATOM   1271 C  CB  . PHE B 1 23  ? 3.35852   13.28298  1.98592   1.000 13.73508 ? 59  PHE E CB  1 
ATOM   1272 C  CG  . PHE B 1 23  ? 4.23727   13.61350  3.16078   1.000 12.59457 ? 59  PHE E CG  1 
ATOM   1273 C  CD1 . PHE B 1 23  ? 5.47057   14.24740  2.95754   1.000 14.75638 ? 59  PHE E CD1 1 
ATOM   1274 C  CD2 . PHE B 1 23  ? 3.80301   13.36757  4.49733   1.000 14.78422 ? 59  PHE E CD2 1 
ATOM   1275 C  CE1 . PHE B 1 23  ? 6.26900   14.59644  4.11458   1.000 14.30543 ? 59  PHE E CE1 1 
ATOM   1276 C  CE2 . PHE B 1 23  ? 4.62420   13.68385  5.61020   1.000 15.04586 ? 59  PHE E CE2 1 
ATOM   1277 C  CZ  . PHE B 1 23  ? 5.84755   14.27100  5.40501   1.000 13.61690 ? 59  PHE E CZ  1 
ATOM   1278 N  N   . HIS B 1 24  ? 0.30880   13.66050  2.40250   1.000 16.13837 ? 60  HIS E N   1 
ATOM   1279 C  CA  . HIS B 1 24  ? -1.05130  13.81885  2.91782   1.000 15.58099 ? 60  HIS E CA  1 
ATOM   1280 C  C   . HIS B 1 24  ? -1.28764  12.92911  4.13643   1.000 16.70609 ? 60  HIS E C   1 
ATOM   1281 O  O   . HIS B 1 24  ? -1.06239  11.70050  4.10885   1.000 15.12855 ? 60  HIS E O   1 
ATOM   1282 C  CB  . HIS B 1 24  ? -2.05826  13.49877  1.77689   1.000 16.03829 ? 60  HIS E CB  1 
ATOM   1283 C  CG  . HIS B 1 24  ? -3.48336  13.35487  2.22315   1.000 17.20685 ? 60  HIS E CG  1 
ATOM   1284 N  ND1 . HIS B 1 24  ? -4.38057  12.52533  1.56754   1.000 19.96776 ? 60  HIS E ND1 1 
ATOM   1285 C  CD2 . HIS B 1 24  ? -4.18347  13.95950  3.21960   1.000 20.74145 ? 60  HIS E CD2 1 
ATOM   1286 C  CE1 . HIS B 1 24  ? -5.55742  12.59526  2.17180   1.000 19.98632 ? 60  HIS E CE1 1 
ATOM   1287 N  NE2 . HIS B 1 24  ? -5.46408  13.45630  3.17794   1.000 19.93950 ? 60  HIS E NE2 1 
ATOM   1288 N  N   . PHE B 1 25  ? -1.77365  13.54353  5.22264   1.000 17.87754 ? 61  PHE E N   1 
ATOM   1289 C  CA  . PHE B 1 25  ? -2.10164  12.76988  6.42236   1.000 16.40542 ? 61  PHE E CA  1 
ATOM   1290 C  C   . PHE B 1 25  ? -3.38177  13.38146  6.98918   1.000 22.00636 ? 61  PHE E C   1 
ATOM   1291 O  O   . PHE B 1 25  ? -3.43130  14.58668  7.24966   1.000 17.68805 ? 61  PHE E O   1 
ATOM   1292 C  CB  . PHE B 1 25  ? -0.93346  12.78661  7.44767   1.000 18.29708 ? 61  PHE E CB  1 
ATOM   1293 C  CG  . PHE B 1 25  ? -1.24937  12.10397  8.75250   1.000 16.55277 ? 61  PHE E CG  1 
ATOM   1294 C  CD1 . PHE B 1 25  ? -1.28746  10.71608  8.86473   1.000 16.91376 ? 61  PHE E CD1 1 
ATOM   1295 C  CD2 . PHE B 1 25  ? -1.52716  12.87011  9.91816   1.000 18.11920 ? 61  PHE E CD2 1 
ATOM   1296 C  CE1 . PHE B 1 25  ? -1.64549  10.08050  10.07157  1.000 18.70949 ? 61  PHE E CE1 1 
ATOM   1297 C  CE2 . PHE B 1 25  ? -1.83912  12.22404  11.14688  1.000 18.61905 ? 61  PHE E CE2 1 
ATOM   1298 C  CZ  . PHE B 1 25  ? -1.90162  10.83993  11.24712  1.000 18.48098 ? 61  PHE E CZ  1 
ATOM   1299 N  N   . GLN B 1 26  ? -4.43180  12.56866  7.10693   1.000 21.86694 ? 62  GLN E N   1 
ATOM   1300 C  CA  . GLN B 1 26  ? -5.70685  13.02132  7.67158   1.000 25.64265 ? 62  GLN E CA  1 
ATOM   1301 C  C   . GLN B 1 26  ? -6.16653  14.16556  6.79059   1.000 25.19977 ? 62  GLN E C   1 
ATOM   1302 O  O   . GLN B 1 26  ? -6.26208  14.01104  5.55996   1.000 27.94091 ? 62  GLN E O   1 
ATOM   1303 C  CB  . GLN B 1 26  ? -5.55983  13.37314  9.14746   1.000 25.04719 ? 62  GLN E CB  1 
ATOM   1304 C  CG  . GLN B 1 26  ? -5.58221  12.26887  10.11424  1.000 23.60600 ? 62  GLN E CG  1 
ATOM   1305 C  CD  . GLN B 1 26  ? -5.28034  12.76748  11.55611  1.000 26.42588 ? 62  GLN E CD  1 
ATOM   1306 O  OE1 . GLN B 1 26  ? -4.95970  13.95256  11.77615  1.000 30.86208 ? 62  GLN E OE1 1 
ATOM   1307 N  NE2 . GLN B 1 26  ? -5.29686  11.84459  12.52007  1.000 24.37693 ? 62  GLN E NE2 1 
ATOM   1308 N  N   . LYS B 1 27  ? -6.43142  15.33067  7.32316   1.000 27.76842 ? 63  LYS E N   1 
ATOM   1309 C  CA  . LYS B 1 27  ? -7.00919  16.33895  6.46005   1.000 29.39396 ? 63  LYS E CA  1 
ATOM   1310 C  C   . LYS B 1 27  ? -5.98953  17.34663  5.96101   1.000 23.81457 ? 63  LYS E C   1 
ATOM   1311 O  O   . LYS B 1 27  ? -6.36935  18.29621  5.29363   1.000 21.71375 ? 63  LYS E O   1 
ATOM   1312 C  CB  . LYS B 1 27  ? -8.19072  16.99207  7.17846   1.000 32.48526 ? 63  LYS E CB  1 
ATOM   1313 C  CG  . LYS B 1 27  ? -9.17830  15.93472  7.72928   1.000 41.09132 ? 63  LYS E CG  1 
ATOM   1314 C  CD  . LYS B 1 27  ? -10.62599 16.48406  7.86384   1.000 46.07813 ? 63  LYS E CD  1 
ATOM   1315 C  CE  . LYS B 1 27  ? -11.65064 15.39977  8.22142   1.000 51.56482 ? 63  LYS E CE  1 
ATOM   1316 N  NZ  . LYS B 1 27  ? -11.30217 14.12283  7.51636   1.000 66.75679 ? 63  LYS E NZ  1 
ATOM   1317 N  N   . SER B 1 28  ? -4.69038  17.09839  6.16528   1.000 19.44960 ? 64  SER E N   1 
ATOM   1318 C  CA  . SER B 1 28  ? -3.68524  18.09245  5.85724   1.000 19.01811 ? 64  SER E CA  1 
ATOM   1319 C  C   . SER B 1 28  ? -2.62717  17.56752  4.88788   1.000 18.09995 ? 64  SER E C   1 
ATOM   1320 O  O   . SER B 1 28  ? -2.35902  16.36869  4.80488   1.000 17.70010 ? 64  SER E O   1 
ATOM   1321 C  CB  . SER B 1 28  ? -2.97276  18.53787  7.14787   1.000 20.11037 ? 64  SER E CB  1 
ATOM   1322 O  OG  . SER B 1 28  ? -3.91333  19.19306  8.03610   1.000 22.11347 ? 64  SER E OG  1 
ATOM   1323 N  N   . LEU B 1 29  ? -1.96634  18.49981  4.24899   1.000 13.69045 ? 65  LEU E N   1 
ATOM   1324 C  CA  . LEU B 1 29  ? -0.68828  18.22230  3.61172   1.000 15.82151 ? 65  LEU E CA  1 
ATOM   1325 C  C   . LEU B 1 29  ? 0.47047   18.72241  4.48630   1.000 16.34493 ? 65  LEU E C   1 
ATOM   1326 O  O   . LEU B 1 29  ? 0.34850   19.77461  5.15192   1.000 16.84105 ? 65  LEU E O   1 
ATOM   1327 C  CB  . LEU B 1 29  ? -0.64643  18.92729  2.27204   1.000 16.10291 ? 65  LEU E CB  1 
ATOM   1328 C  CG  . LEU B 1 29  ? -1.56286  18.26954  1.23332   1.000 20.95819 ? 65  LEU E CG  1 
ATOM   1329 C  CD1 . LEU B 1 29  ? -1.65332  19.28682  0.09584   1.000 20.02594 ? 65  LEU E CD1 1 
ATOM   1330 C  CD2 . LEU B 1 29  ? -0.84855  16.95985  0.77711   1.000 18.09088 ? 65  LEU E CD2 1 
ATOM   1331 N  N   . TYR B 1 30  ? 1.60469   18.00043  4.42847   1.000 16.17824 ? 66  TYR E N   1 
ATOM   1332 C  CA  . TYR B 1 30  ? 2.78128   18.31747  5.24076   1.000 13.81351 ? 66  TYR E CA  1 
ATOM   1333 C  C   . TYR B 1 30  ? 3.98929   18.40915  4.30924   1.000 15.36454 ? 66  TYR E C   1 
ATOM   1334 O  O   . TYR B 1 30  ? 4.02840   17.78715  3.23455   1.000 14.56405 ? 66  TYR E O   1 
ATOM   1335 C  CB  . TYR B 1 30  ? 3.02736   17.29657  6.32912   1.000 13.43515 ? 66  TYR E CB  1 
ATOM   1336 C  CG  . TYR B 1 30  ? 1.87919   17.14842  7.29799   1.000 14.27858 ? 66  TYR E CG  1 
ATOM   1337 C  CD1 . TYR B 1 30  ? 0.77373   16.36449  6.96996   1.000 14.65143 ? 66  TYR E CD1 1 
ATOM   1338 C  CD2 . TYR B 1 30  ? 1.87220   17.81609  8.50730   1.000 14.18925 ? 66  TYR E CD2 1 
ATOM   1339 C  CE1 . TYR B 1 30  ? -0.29364  16.20282  7.90374   1.000 13.40602 ? 66  TYR E CE1 1 
ATOM   1340 C  CE2 . TYR B 1 30  ? 0.83297   17.65308  9.44056   1.000 13.11592 ? 66  TYR E CE2 1 
ATOM   1341 C  CZ  . TYR B 1 30  ? -0.26907  16.87983  9.10118   1.000 16.60233 ? 66  TYR E CZ  1 
ATOM   1342 O  OH  . TYR B 1 30  ? -1.32804  16.74325  9.99101   1.000 17.14370 ? 66  TYR E OH  1 
ATOM   1343 N  N   . TYR B 1 31  ? 4.94762   19.24067  4.70943   1.000 13.57663 ? 67  TYR E N   1 
ATOM   1344 C  CA  . TYR B 1 31  ? 6.16799   19.50572  3.96324   1.000 14.74740 ? 67  TYR E CA  1 
ATOM   1345 C  C   . TYR B 1 31  ? 7.29049   19.45047  4.98689   1.000 17.34875 ? 67  TYR E C   1 
ATOM   1346 O  O   . TYR B 1 31  ? 7.22873   20.17426  5.98326   1.000 14.42269 ? 67  TYR E O   1 
ATOM   1347 C  CB  . TYR B 1 31  ? 6.16187   20.92356  3.33416   1.000 18.52399 ? 67  TYR E CB  1 
ATOM   1348 C  CG  . TYR B 1 31  ? 7.33904   21.17211  2.42314   1.000 20.89008 ? 67  TYR E CG  1 
ATOM   1349 C  CD1 . TYR B 1 31  ? 7.35192   20.60627  1.16475   1.000 24.13253 ? 67  TYR E CD1 1 
ATOM   1350 C  CD2 . TYR B 1 31  ? 8.44092   21.96033  2.80463   1.000 23.89886 ? 67  TYR E CD2 1 
ATOM   1351 C  CE1 . TYR B 1 31  ? 8.43617   20.78378  0.27960   1.000 26.36669 ? 67  TYR E CE1 1 
ATOM   1352 C  CE2 . TYR B 1 31  ? 9.56872   22.17231  1.88627   1.000 23.21614 ? 67  TYR E CE2 1 
ATOM   1353 C  CZ  . TYR B 1 31  ? 9.52813   21.56457  0.62723   1.000 28.97361 ? 67  TYR E CZ  1 
ATOM   1354 O  OH  . TYR B 1 31  ? 10.52795  21.66700  -0.35891  1.000 34.31528 ? 67  TYR E OH  1 
ATOM   1355 N  N   . ILE B 1 32  ? 8.30558   18.63427  4.74101   1.000 13.52515 ? 68  ILE E N   1 
ATOM   1356 C  CA  . ILE B 1 32  ? 9.51343   18.61384  5.57370   1.000 14.08987 ? 68  ILE E CA  1 
ATOM   1357 C  C   . ILE B 1 32  ? 10.59633  19.32967  4.79711   1.000 15.43981 ? 68  ILE E C   1 
ATOM   1358 O  O   . ILE B 1 32  ? 10.82663  18.97824  3.62977   1.000 15.45224 ? 68  ILE E O   1 
ATOM   1359 C  CB  . ILE B 1 32  ? 9.92810   17.16459  5.89390   1.000 15.84337 ? 68  ILE E CB  1 
ATOM   1360 C  CG1 . ILE B 1 32  ? 8.93635   16.55158  6.85383   1.000 14.71867 ? 68  ILE E CG1 1 
ATOM   1361 C  CG2 . ILE B 1 32  ? 11.37784  17.07588  6.45398   1.000 16.87312 ? 68  ILE E CG2 1 
ATOM   1362 C  CD1 . ILE B 1 32  ? 9.14638   15.01390  6.97293   1.000 17.50178 ? 68  ILE E CD1 1 
ATOM   1363 N  N   . SER B 1 33  ? 11.22475  20.36858  5.42042   1.000 15.36524 ? 69  SER E N   1 
ATOM   1364 C  CA  . SER B 1 33  ? 12.24338  21.16897  4.72221   1.000 15.85516 ? 69  SER E CA  1 
ATOM   1365 C  C   . SER B 1 33  ? 13.46778  20.33692  4.32219   1.000 15.75478 ? 69  SER E C   1 
ATOM   1366 O  O   . SER B 1 33  ? 13.79271  19.29033  4.90559   1.000 16.11266 ? 69  SER E O   1 
ATOM   1367 C  CB  . SER B 1 33  ? 12.67726  22.33783  5.61822   1.000 13.65721 ? 69  SER E CB  1 
ATOM   1368 O  OG  . SER B 1 33  ? 13.43828  21.78633  6.67593   1.000 14.41258 ? 69  SER E OG  1 
ATOM   1369 N  N   . SER B 1 34  ? 14.18870  20.82703  3.30049   1.000 18.44453 ? 70  SER E N   1 
ATOM   1370 C  CA  . SER B 1 34  ? 15.47818  20.20055  3.03468   1.000 21.49018 ? 70  SER E CA  1 
ATOM   1371 C  C   . SER B 1 34  ? 16.62465  21.03939  3.57390   1.000 20.63436 ? 70  SER E C   1 
ATOM   1372 O  O   . SER B 1 34  ? 17.77463  20.61326  3.46873   1.000 23.12331 ? 70  SER E O   1 
ATOM   1373 C  CB  . SER B 1 34  ? 15.66360  19.94311  1.53593   1.000 24.19380 ? 70  SER E CB  1 
ATOM   1374 O  OG  . SER B 1 34  ? 15.60810  21.18548  0.84367   1.000 27.74896 ? 70  SER E OG  1 
ATOM   1375 N  N   . VAL B 1 35  ? 16.31657  22.14544  4.27291   1.000 15.92075 ? 71  VAL E N   1 
ATOM   1376 C  CA  . VAL B 1 35  ? 17.34990  22.94209  4.92092   1.000 15.20371 ? 71  VAL E CA  1 
ATOM   1377 C  C   . VAL B 1 35  ? 16.92991  23.23947  6.35722   1.000 14.49943 ? 71  VAL E C   1 
ATOM   1378 O  O   . VAL B 1 35  ? 15.75212  23.14239  6.71174   1.000 18.04784 ? 71  VAL E O   1 
ATOM   1379 C  CB  . VAL B 1 35  ? 17.60306  24.25595  4.15500   1.000 15.45144 ? 71  VAL E CB  1 
ATOM   1380 C  CG1 . VAL B 1 35  ? 18.07706  23.91137  2.72133   1.000 18.82109 ? 71  VAL E CG1 1 
ATOM   1381 C  CG2 . VAL B 1 35  ? 16.34544  25.14129  4.17945   1.000 16.30172 ? 71  VAL E CG2 1 
ATOM   1382 N  N   . LYS B 1 36  ? 17.90565  23.64408  7.17079   1.000 14.91522 ? 72  LYS E N   1 
ATOM   1383 C  CA  . LYS B 1 36  ? 17.59707  24.11168  8.51894   1.000 11.49941 ? 72  LYS E CA  1 
ATOM   1384 C  C   . LYS B 1 36  ? 17.41239  25.61561  8.47207   1.000 13.68088 ? 72  LYS E C   1 
ATOM   1385 O  O   . LYS B 1 36  ? 17.97096  26.31195  7.60646   1.000 13.72896 ? 72  LYS E O   1 
ATOM   1386 C  CB  . LYS B 1 36  ? 18.72337  23.74294  9.49920   1.000 12.36405 ? 72  LYS E CB  1 
ATOM   1387 C  CG  . LYS B 1 36  ? 18.94986  22.18354  9.59417   1.000 12.06285 ? 72  LYS E CG  1 
ATOM   1388 C  CD  . LYS B 1 36  ? 19.79999  21.79291  10.81782  1.000 16.95180 ? 72  LYS E CD  1 
ATOM   1389 C  CE  . LYS B 1 36  ? 19.99419  20.27551  10.94492  1.000 19.43720 ? 72  LYS E CE  1 
ATOM   1390 N  NZ  . LYS B 1 36  ? 20.65608  19.91325  12.25815  1.000 17.65100 ? 72  LYS E NZ  1 
ATOM   1391 N  N   . ASN B 1 37  ? 16.62939  26.11646  9.40221   1.000 13.77557 ? 73  ASN E N   1 
ATOM   1392 C  CA  . ASN B 1 37  ? 16.56323  27.57219  9.50089   1.000 12.03921 ? 73  ASN E CA  1 
ATOM   1393 C  C   . ASN B 1 37  ? 16.11364  27.99387  10.89173  1.000 13.33213 ? 73  ASN E C   1 
ATOM   1394 O  O   . ASN B 1 37  ? 15.73141  27.16429  11.72579  1.000 14.63477 ? 73  ASN E O   1 
ATOM   1395 C  CB  . ASN B 1 37  ? 15.58077  28.14133  8.45458   1.000 13.31837 ? 73  ASN E CB  1 
ATOM   1396 C  CG  . ASN B 1 37  ? 16.17613  29.34199  7.75886   1.000 14.43704 ? 73  ASN E CG  1 
ATOM   1397 O  OD1 . ASN B 1 37  ? 16.91808  30.07580  8.39936   1.000 14.65914 ? 73  ASN E OD1 1 
ATOM   1398 N  ND2 . ASN B 1 37  ? 15.84487  29.55951  6.47767   1.000 11.79095 ? 73  ASN E ND2 1 
ATOM   1399 N  N   . THR B 1 38  ? 16.12196  29.32038  11.10899  1.000 13.81796 ? 74  THR E N   1 
ATOM   1400 C  CA  . THR B 1 38  ? 15.57327  29.85330  12.36442  1.000 13.53021 ? 74  THR E CA  1 
ATOM   1401 C  C   . THR B 1 38  ? 14.08861  29.58366  12.39715  1.000 11.82322 ? 74  THR E C   1 
ATOM   1402 O  O   . THR B 1 38  ? 13.45774  29.34368  11.37969  1.000 12.72231 ? 74  THR E O   1 
ATOM   1403 C  CB  . THR B 1 38  ? 15.81218  31.35322  12.48346  1.000 15.87998 ? 74  THR E CB  1 
ATOM   1404 O  OG1 . THR B 1 38  ? 15.12518  32.06340  11.42796  1.000 15.32105 ? 74  THR E OG1 1 
ATOM   1405 C  CG2 . THR B 1 38  ? 17.40116  31.62724  12.42643  1.000 14.82344 ? 74  THR E CG2 1 
ATOM   1406 N  N   . TRP B 1 39  ? 13.51594  29.62692  13.60941  1.000 12.36626 ? 75  TRP E N   1 
ATOM   1407 C  CA  . TRP B 1 39  ? 12.08505  29.37754  13.68782  1.000 12.32961 ? 75  TRP E CA  1 
ATOM   1408 C  C   . TRP B 1 39  ? 11.33736  30.38157  12.82317  1.000 12.86164 ? 75  TRP E C   1 
ATOM   1409 O  O   . TRP B 1 39  ? 10.39183  30.02207  12.10162  1.000 12.61226 ? 75  TRP E O   1 
ATOM   1410 C  CB  . TRP B 1 39  ? 11.62866  29.42208  15.17023  1.000 9.93572  ? 75  TRP E CB  1 
ATOM   1411 C  CG  . TRP B 1 39  ? 10.15985  29.00496  15.39096  1.000 12.82691 ? 75  TRP E CG  1 
ATOM   1412 C  CD1 . TRP B 1 39  ? 9.68230   27.75730  15.72077  1.000 11.96981 ? 75  TRP E CD1 1 
ATOM   1413 C  CD2 . TRP B 1 39  ? 9.00935   29.87554  15.30209  1.000 12.11763 ? 75  TRP E CD2 1 
ATOM   1414 N  NE1 . TRP B 1 39  ? 8.31048   27.81650  15.86130  1.000 12.26157 ? 75  TRP E NE1 1 
ATOM   1415 C  CE2 . TRP B 1 39  ? 7.86891   29.09351  15.60806  1.000 13.92151 ? 75  TRP E CE2 1 
ATOM   1416 C  CE3 . TRP B 1 39  ? 8.84401   31.23768  15.00489  1.000 12.12938 ? 75  TRP E CE3 1 
ATOM   1417 C  CZ2 . TRP B 1 39  ? 6.55173   29.60770  15.59192  1.000 15.27417 ? 75  TRP E CZ2 1 
ATOM   1418 C  CZ3 . TRP B 1 39  ? 7.51796   31.77304  14.99867  1.000 17.20875 ? 75  TRP E CZ3 1 
ATOM   1419 C  CH2 . TRP B 1 39  ? 6.39961   30.96422  15.27942  1.000 15.55947 ? 75  TRP E CH2 1 
ATOM   1420 N  N   . HIS B 1 40  ? 11.77298  31.65180  12.85612  1.000 14.73105 ? 76  HIS E N   1 
ATOM   1421 C  CA  . HIS B 1 40  ? 11.02317  32.67259  12.13613  1.000 15.01750 ? 76  HIS E CA  1 
ATOM   1422 C  C   . HIS B 1 40  ? 11.17902  32.53111  10.63243  1.000 13.52281 ? 76  HIS E C   1 
ATOM   1423 O  O   . HIS B 1 40  ? 10.24782  32.82209  9.89204   1.000 14.46338 ? 76  HIS E O   1 
ATOM   1424 C  CB  . HIS B 1 40  ? 11.49373  34.07290  12.55511  1.000 15.61683 ? 76  HIS E CB  1 
ATOM   1425 C  CG  . HIS B 1 40  ? 11.12973  34.37817  13.97556  1.000 17.86134 ? 76  HIS E CG  1 
ATOM   1426 N  ND1 . HIS B 1 40  ? 12.04996  34.37220  14.99681  1.000 26.51713 ? 76  HIS E ND1 1 
ATOM   1427 C  CD2 . HIS B 1 40  ? 9.92846   34.64801  14.54406  1.000 21.06778 ? 76  HIS E CD2 1 
ATOM   1428 C  CE1 . HIS B 1 40  ? 11.44259  34.66387  16.13536  1.000 23.28146 ? 76  HIS E CE1 1 
ATOM   1429 N  NE2 . HIS B 1 40  ? 10.15017  34.80329  15.88962  1.000 23.89425 ? 76  HIS E NE2 1 
ATOM   1430 N  N   . LEU B 1 41  ? 12.37536  32.18933  10.15581  1.000 14.02627 ? 77  LEU E N   1 
ATOM   1431 C  CA  . LEU B 1 41  ? 12.46672  32.03848  8.71265   1.000 13.02429 ? 77  LEU E CA  1 
ATOM   1432 C  C   . LEU B 1 41  ? 11.82313  30.72734  8.23728   1.000 13.52595 ? 77  LEU E C   1 
ATOM   1433 O  O   . LEU B 1 41  ? 11.37835  30.65706  7.06216   1.000 16.54416 ? 77  LEU E O   1 
ATOM   1434 C  CB  . LEU B 1 41  ? 13.92797  32.06347  8.21933   1.000 13.86858 ? 77  LEU E CB  1 
ATOM   1435 C  CG  . LEU B 1 41  ? 14.60760  33.45104  8.35853   1.000 15.97425 ? 77  LEU E CG  1 
ATOM   1436 C  CD1 . LEU B 1 41  ? 16.13120  33.48471  8.09483   1.000 17.49416 ? 77  LEU E CD1 1 
ATOM   1437 C  CD2 . LEU B 1 41  ? 13.86786  34.45219  7.40191   1.000 20.89623 ? 77  LEU E CD2 1 
ATOM   1438 N  N   . SER B 1 42  ? 11.81835  29.69289  9.08587   1.000 12.56281 ? 78  SER E N   1 
ATOM   1439 C  CA  . SER B 1 42  ? 11.03195  28.49215  8.77275   1.000 14.91973 ? 78  SER E CA  1 
ATOM   1440 C  C   . SER B 1 42  ? 9.58616   28.87778  8.57788   1.000 13.12057 ? 78  SER E C   1 
ATOM   1441 O  O   . SER B 1 42  ? 8.94522   28.47010  7.61044   1.000 14.71089 ? 78  SER E O   1 
ATOM   1442 C  CB  . SER B 1 42  ? 11.11021  27.45098  9.90111   1.000 12.01372 ? 78  SER E CB  1 
ATOM   1443 O  OG  . SER B 1 42  ? 12.50165  27.07124  10.12176  1.000 14.07332 ? 78  SER E OG  1 
ATOM   1444 N  N   . ARG B 1 43  ? 9.03846   29.63578  9.53362   1.000 14.79247 ? 79  ARG E N   1 
ATOM   1445 C  CA  . ARG B 1 43  ? 7.64370   30.05995  9.43043   1.000 14.34235 ? 79  ARG E CA  1 
ATOM   1446 C  C   . ARG B 1 43  ? 7.38336   30.84091  8.14375   1.000 16.53171 ? 79  ARG E C   1 
ATOM   1447 O  O   . ARG B 1 43  ? 6.35011   30.61364  7.47463   1.000 15.26991 ? 79  ARG E O   1 
ATOM   1448 C  CB  . ARG B 1 43  ? 7.22764   30.91241  10.63530  1.000 14.01548 ? 79  ARG E CB  1 
ATOM   1449 C  CG  . ARG B 1 43  ? 5.70151   31.09647  10.57690  1.000 17.90101 ? 79  ARG E CG  1 
ATOM   1450 C  CD  . ARG B 1 43  ? 5.09592   31.88609  11.75940  1.000 15.64363 ? 79  ARG E CD  1 
ATOM   1451 N  NE  . ARG B 1 43  ? 3.63377   31.80727  11.61439  1.000 15.46770 ? 79  ARG E NE  1 
ATOM   1452 C  CZ  . ARG B 1 43  ? 2.82946   32.78424  12.00024  1.000 23.21553 ? 79  ARG E CZ  1 
ATOM   1453 N  NH1 . ARG B 1 43  ? 3.32190   33.85935  12.61635  1.000 23.86094 ? 79  ARG E NH1 1 
ATOM   1454 N  NH2 . ARG B 1 43  ? 1.50279   32.66779  11.79780  1.000 18.79354 ? 79  ARG E NH2 1 
ATOM   1455 N  N   . GLU B 1 44  ? 8.29306   31.76320  7.79363   1.000 16.54562 ? 80  GLU E N   1 
ATOM   1456 C  CA  . GLU B 1 44  ? 8.11938   32.54949  6.57427   1.000 18.87606 ? 80  GLU E CA  1 
ATOM   1457 C  C   . GLU B 1 44  ? 8.02848   31.65923  5.33695   1.000 19.50205 ? 80  GLU E C   1 
ATOM   1458 O  O   . GLU B 1 44  ? 7.22691   31.92983  4.43732   1.000 15.56465 ? 80  GLU E O   1 
ATOM   1459 C  CB  . GLU B 1 44  ? 9.27603   33.50967  6.40121   1.000 19.60183 ? 80  GLU E CB  1 
ATOM   1460 C  CG  . GLU B 1 44  ? 9.04817   34.82590  7.13428   1.000 26.64457 ? 80  GLU E CG  1 
ATOM   1461 C  CD  . GLU B 1 44  ? 10.16505  35.79307  6.78423   1.000 31.70342 ? 80  GLU E CD  1 
ATOM   1462 O  OE1 . GLU B 1 44  ? 10.58929  35.81275  5.59442   1.000 38.95880 ? 80  GLU E OE1 1 
ATOM   1463 O  OE2 . GLU B 1 44  ? 10.65288  36.46107  7.71962   1.000 37.73185 ? 80  GLU E OE2 1 
ATOM   1464 N  N   . TYR B 1 45  ? 8.85558   30.60617  5.25696   1.000 16.56102 ? 81  TYR E N   1 
ATOM   1465 C  CA  . TYR B 1 45  ? 8.73942   29.69970  4.11427   1.000 16.18051 ? 81  TYR E CA  1 
ATOM   1466 C  C   . TYR B 1 45  ? 7.33573   29.09056  4.05411   1.000 17.42136 ? 81  TYR E C   1 
ATOM   1467 O  O   . TYR B 1 45  ? 6.68362   29.09384  3.00032   1.000 17.89204 ? 81  TYR E O   1 
ATOM   1468 C  CB  . TYR B 1 45  ? 9.81732   28.59037  4.17592   1.000 15.07816 ? 81  TYR E CB  1 
ATOM   1469 C  CG  . TYR B 1 45  ? 9.66219   27.60055  3.04319   1.000 16.27783 ? 81  TYR E CG  1 
ATOM   1470 C  CD1 . TYR B 1 45  ? 8.79036   26.49348  3.15001   1.000 14.44574 ? 81  TYR E CD1 1 
ATOM   1471 C  CD2 . TYR B 1 45  ? 10.33037  27.80122  1.83929   1.000 17.71023 ? 81  TYR E CD2 1 
ATOM   1472 C  CE1 . TYR B 1 45  ? 8.59983   25.62439  2.05563   1.000 16.13356 ? 81  TYR E CE1 1 
ATOM   1473 C  CE2 . TYR B 1 45  ? 10.16622  26.89899  0.76545   1.000 18.00015 ? 81  TYR E CE2 1 
ATOM   1474 C  CZ  . TYR B 1 45  ? 9.32461   25.81722  0.90067   1.000 19.44060 ? 81  TYR E CZ  1 
ATOM   1475 O  OH  . TYR B 1 45  ? 9.20556   24.95326  -0.16234  1.000 20.24370 ? 81  TYR E OH  1 
ATOM   1476 N  N   . CYS B 1 46  ? 6.84272   28.57634  5.19166   1.000 15.70458 ? 82  CYS E N   1 
ATOM   1477 C  CA  . CYS B 1 46  ? 5.54360   27.92012  5.18486   1.000 14.95688 ? 82  CYS E CA  1 
ATOM   1478 C  C   . CYS B 1 46  ? 4.46266   28.90482  4.78149   1.000 17.74876 ? 82  CYS E C   1 
ATOM   1479 O  O   . CYS B 1 46  ? 3.56908   28.57195  3.99320   1.000 18.31522 ? 82  CYS E O   1 
ATOM   1480 C  CB  . CYS B 1 46  ? 5.22161   27.37821  6.57967   1.000 13.53004 ? 82  CYS E CB  1 
ATOM   1481 S  SG  . CYS B 1 46  ? 6.36636   26.08144  7.13039   1.000 15.23195 ? 82  CYS E SG  1 
ATOM   1482 N  N   . LEU B 1 47  ? 4.50456   30.13164  5.33852   1.000 14.69893 ? 83  LEU E N   1 
ATOM   1483 C  CA  . LEU B 1 47  ? 3.47541   31.13591  4.96581   1.000 14.03460 ? 83  LEU E CA  1 
ATOM   1484 C  C   . LEU B 1 47  ? 3.48479   31.36551  3.46418   1.000 18.14093 ? 83  LEU E C   1 
ATOM   1485 O  O   . LEU B 1 47  ? 2.42593   31.47368  2.83628   1.000 18.99278 ? 83  LEU E O   1 
ATOM   1486 C  CB  . LEU B 1 47  ? 3.76717   32.48873  5.65913   1.000 18.49825 ? 83  LEU E CB  1 
ATOM   1487 C  CG  . LEU B 1 47  ? 3.67502   32.49844  7.19731   1.000 20.75838 ? 83  LEU E CG  1 
ATOM   1488 C  CD1 . LEU B 1 47  ? 3.94050   33.96312  7.73753   1.000 23.63127 ? 83  LEU E CD1 1 
ATOM   1489 C  CD2 . LEU B 1 47  ? 2.34602   32.06422  7.62912   1.000 19.80898 ? 83  LEU E CD2 1 
ATOM   1490 N  N   . GLN B 1 48  ? 4.67185   31.48259  2.87458   1.000 18.63588 ? 84  GLN E N   1 
ATOM   1491 C  CA  . GLN B 1 48  ? 4.72003   31.81812  1.45539   1.000 22.78146 ? 84  GLN E CA  1 
ATOM   1492 C  C   . GLN B 1 48  ? 4.28929   30.67433  0.55900   1.000 22.56644 ? 84  GLN E C   1 
ATOM   1493 O  O   . GLN B 1 48  ? 4.07731   30.90367  -0.65083  1.000 22.21319 ? 84  GLN E O   1 
ATOM   1494 C  CB  . GLN B 1 48  ? 6.11455   32.28371  1.04118   1.000 23.89018 ? 84  GLN E CB  1 
ATOM   1495 C  CG  . GLN B 1 48  ? 6.40044   33.71738  1.52980   1.000 29.66121 ? 84  GLN E CG  1 
ATOM   1496 C  CD  . GLN B 1 48  ? 7.84721   33.99380  1.81615   1.000 37.35539 ? 84  GLN E CD  1 
ATOM   1497 O  OE1 . GLN B 1 48  ? 8.73778   33.31940  1.27222   1.000 39.62136 ? 84  GLN E OE1 1 
ATOM   1498 N  NE2 . GLN B 1 48  ? 8.10607   35.02298  2.64529   1.000 38.10169 ? 84  GLN E NE2 1 
ATOM   1499 N  N   . GLU B 1 49  ? 4.12025   29.47922  1.10327   1.000 19.68819 ? 85  GLU E N   1 
ATOM   1500 C  CA  . GLU B 1 49  ? 3.48524   28.37109  0.37990   1.000 18.12988 ? 85  GLU E CA  1 
ATOM   1501 C  C   . GLU B 1 49  ? 2.00381   28.28419  0.66629   1.000 19.97039 ? 85  GLU E C   1 
ATOM   1502 O  O   . GLU B 1 49  ? 1.34597   27.30417  0.24665   1.000 19.84338 ? 85  GLU E O   1 
ATOM   1503 C  CB  . GLU B 1 49  ? 4.15529   27.04282  0.77477   1.000 21.22622 ? 85  GLU E CB  1 
ATOM   1504 C  CG  . GLU B 1 49  ? 5.63571   27.03366  0.51350   1.000 20.39995 ? 85  GLU E CG  1 
ATOM   1505 C  CD  . GLU B 1 49  ? 5.95555   26.97970  -0.98043  1.000 27.12984 ? 85  GLU E CD  1 
ATOM   1506 O  OE1 . GLU B 1 49  ? 5.13718   26.46982  -1.78410  1.000 24.88324 ? 85  GLU E OE1 1 
ATOM   1507 O  OE2 . GLU B 1 49  ? 7.02730   27.44811  -1.33595  1.000 28.38909 ? 85  GLU E OE2 1 
ATOM   1508 N  N   . GLY B 1 50  ? 1.46154   29.26440  1.39155   1.000 18.35854 ? 86  GLY E N   1 
ATOM   1509 C  CA  . GLY B 1 50  ? 0.05086   29.22296  1.69022   1.000 18.57252 ? 86  GLY E CA  1 
ATOM   1510 C  C   . GLY B 1 50  ? -0.27939  28.34545  2.86101   1.000 17.85466 ? 86  GLY E C   1 
ATOM   1511 O  O   . GLY B 1 50  ? -1.43186  27.90453  3.01509   1.000 18.51953 ? 86  GLY E O   1 
ATOM   1512 N  N   . ALA B 1 51  ? 0.70447   28.09773  3.72394   1.000 17.20612 ? 87  ALA E N   1 
ATOM   1513 C  CA  . ALA B 1 51  ? 0.56810   27.15863  4.81200   1.000 14.85757 ? 87  ALA E CA  1 
ATOM   1514 C  C   . ALA B 1 51  ? 1.09347   27.88452  6.05523   1.000 17.30548 ? 87  ALA E C   1 
ATOM   1515 O  O   . ALA B 1 51  ? 1.16373   29.12659  6.12873   1.000 17.97058 ? 87  ALA E O   1 
ATOM   1516 C  CB  . ALA B 1 51  ? 1.35589   25.85916  4.52144   1.000 14.25058 ? 87  ALA E CB  1 
ATOM   1517 N  N   . ASP B 1 52  ? 1.43580   27.10108  7.06391   1.000 16.61098 ? 88  ASP E N   1 
ATOM   1518 C  CA  . ASP B 1 52  ? 2.08643   27.62440  8.27477   1.000 15.34074 ? 88  ASP E CA  1 
ATOM   1519 C  C   . ASP B 1 52  ? 2.87724   26.48233  8.88016   1.000 14.91413 ? 88  ASP E C   1 
ATOM   1520 O  O   . ASP B 1 52  ? 2.82845   25.35643  8.39335   1.000 16.35241 ? 88  ASP E O   1 
ATOM   1521 C  CB  . ASP B 1 52  ? 1.02851   28.17727  9.25222   1.000 14.79610 ? 88  ASP E CB  1 
ATOM   1522 C  CG  . ASP B 1 52  ? 1.51862   29.36243  10.04946  1.000 18.93187 ? 88  ASP E CG  1 
ATOM   1523 O  OD1 . ASP B 1 52  ? 2.71809   29.36964  10.39487  1.000 16.83993 ? 88  ASP E OD1 1 
ATOM   1524 O  OD2 . ASP B 1 52  ? 0.68056   30.24717  10.39623  1.000 17.95392 ? 88  ASP E OD2 1 
ATOM   1525 N  N   . LEU B 1 53  ? 3.58987   26.76428  9.96769   1.000 14.55424 ? 89  LEU E N   1 
ATOM   1526 C  CA  . LEU B 1 53  ? 4.24907   25.66816  10.64126  1.000 12.69636 ? 89  LEU E CA  1 
ATOM   1527 C  C   . LEU B 1 53  ? 3.21057   24.66114  11.21342  1.000 13.66021 ? 89  LEU E C   1 
ATOM   1528 O  O   . LEU B 1 53  ? 2.01894   24.96948  11.42606  1.000 14.78612 ? 89  LEU E O   1 
ATOM   1529 C  CB  . LEU B 1 53  ? 5.15034   26.22490  11.75485  1.000 13.30218 ? 89  LEU E CB  1 
ATOM   1530 C  CG  . LEU B 1 53  ? 6.48271   26.90552  11.32004  1.000 12.09254 ? 89  LEU E CG  1 
ATOM   1531 C  CD1 . LEU B 1 53  ? 7.18097   27.63639  12.55630  1.000 13.98580 ? 89  LEU E CD1 1 
ATOM   1532 C  CD2 . LEU B 1 53  ? 7.50956   25.85447  10.69148  1.000 11.19897 ? 89  LEU E CD2 1 
ATOM   1533 N  N   . ALA B 1 54  ? 3.64788   23.43332  11.43380  1.000 13.33023 ? 90  ALA E N   1 
ATOM   1534 C  CA  . ALA B 1 54  ? 2.69100   22.38496  11.82668  1.000 15.90164 ? 90  ALA E CA  1 
ATOM   1535 C  C   . ALA B 1 54  ? 2.04084   22.66199  13.19310  1.000 15.29649 ? 90  ALA E C   1 
ATOM   1536 O  O   . ALA B 1 54  ? 2.69081   23.15854  14.12207  1.000 15.71788 ? 90  ALA E O   1 
ATOM   1537 C  CB  . ALA B 1 54  ? 3.39343   21.02344  11.86720  1.000 12.69682 ? 90  ALA E CB  1 
ATOM   1538 N  N   . ILE B 1 55  ? 0.74736   22.33351  13.29870  1.000 13.50423 ? 91  ILE E N   1 
ATOM   1539 C  CA  . ILE B 1 55  ? -0.04584  22.51093  14.52037  1.000 13.83360 ? 91  ILE E CA  1 
ATOM   1540 C  C   . ILE B 1 55  ? -0.47367  21.11354  14.95139  1.000 14.64480 ? 91  ILE E C   1 
ATOM   1541 O  O   . ILE B 1 55  ? -1.14634  20.40247  14.17680  1.000 15.34286 ? 91  ILE E O   1 
ATOM   1542 C  CB  . ILE B 1 55  ? -1.29967  23.39062  14.28121  1.000 13.52757 ? 91  ILE E CB  1 
ATOM   1543 C  CG1 . ILE B 1 55  ? -0.88160  24.85914  13.89227  1.000 15.87633 ? 91  ILE E CG1 1 
ATOM   1544 C  CG2 . ILE B 1 55  ? -2.19727  23.34175  15.53246  1.000 15.06812 ? 91  ILE E CG2 1 
ATOM   1545 C  CD1 . ILE B 1 55  ? -2.10032  25.69686  13.31830  1.000 16.42344 ? 91  ILE E CD1 1 
ATOM   1546 N  N   . ILE B 1 56  ? -0.13488  20.71996  16.16131  1.000 11.98784 ? 92  ILE E N   1 
ATOM   1547 C  CA  . ILE B 1 56  ? -0.40023  19.34420  16.59139  1.000 16.91730 ? 92  ILE E CA  1 
ATOM   1548 C  C   . ILE B 1 56  ? -1.76869  19.34984  17.30060  1.000 19.77694 ? 92  ILE E C   1 
ATOM   1549 O  O   . ILE B 1 56  ? -1.91531  19.94411  18.38016  1.000 19.61277 ? 92  ILE E O   1 
ATOM   1550 C  CB  . ILE B 1 56  ? 0.71258   18.78702  17.48847  1.000 19.29306 ? 92  ILE E CB  1 
ATOM   1551 C  CG1 . ILE B 1 56  ? 2.12821   18.86660  16.81769  1.000 15.75095 ? 92  ILE E CG1 1 
ATOM   1552 C  CG2 . ILE B 1 56  ? 0.35386   17.34214  17.99798  1.000 21.12150 ? 92  ILE E CG2 1 
ATOM   1553 C  CD1 . ILE B 1 56  ? 2.20548   18.27530  15.39792  1.000 19.19779 ? 92  ILE E CD1 1 
ATOM   1554 N  N   . ASN B 1 57  ? -2.77486  18.68843  16.69424  1.000 19.81851 ? 93  ASN E N   1 
ATOM   1555 C  CA  . ASN B 1 57  ? -4.16300  18.74907  17.17851  1.000 20.73135 ? 93  ASN E CA  1 
ATOM   1556 C  C   . ASN B 1 57  ? -4.66470  17.45384  17.79137  1.000 26.11375 ? 93  ASN E C   1 
ATOM   1557 O  O   . ASN B 1 57  ? -5.77201  17.44773  18.34702  1.000 26.32072 ? 93  ASN E O   1 
ATOM   1558 C  CB  . ASN B 1 57  ? -5.11864  19.12612  16.03308  1.000 23.70533 ? 93  ASN E CB  1 
ATOM   1559 C  CG  . ASN B 1 57  ? -4.76207  20.43194  15.38228  1.000 22.29568 ? 93  ASN E CG  1 
ATOM   1560 O  OD1 . ASN B 1 57  ? -4.06504  20.45405  14.34168  1.000 19.52045 ? 93  ASN E OD1 1 
ATOM   1561 N  ND2 . ASN B 1 57  ? -5.25135  21.53818  15.95514  1.000 21.58568 ? 93  ASN E ND2 1 
ATOM   1562 N  N   . SER B 1 58  ? -3.90768  16.36190  17.70482  1.000 21.89444 ? 94  SER E N   1 
ATOM   1563 C  CA  . SER B 1 58  ? -4.33178  15.11945  18.31254  1.000 24.29537 ? 94  SER E CA  1 
ATOM   1564 C  C   . SER B 1 58  ? -3.12635  14.24889  18.64384  1.000 26.71465 ? 94  SER E C   1 
ATOM   1565 O  O   . SER B 1 58  ? -2.01590  14.44274  18.13084  1.000 22.61820 ? 94  SER E O   1 
ATOM   1566 C  CB  . SER B 1 58  ? -5.29332  14.37632  17.37159  1.000 23.13964 ? 94  SER E CB  1 
ATOM   1567 O  OG  . SER B 1 58  ? -4.57996  13.89440  16.23495  1.000 24.87367 ? 94  SER E OG  1 
ATOM   1568 N  N   . ARG B 1 59  ? -3.36850  13.24731  19.48939  1.000 23.61100 ? 95  ARG E N   1 
ATOM   1569 C  CA  . ARG B 1 59  ? -2.33349  12.25969  19.77134  1.000 24.93685 ? 95  ARG E CA  1 
ATOM   1570 C  C   . ARG B 1 59  ? -1.84747  11.59439  18.49484  1.000 21.93453 ? 95  ARG E C   1 
ATOM   1571 O  O   . ARG B 1 59  ? -0.65512  11.32809  18.35774  1.000 23.67612 ? 95  ARG E O   1 
ATOM   1572 C  CB  . ARG B 1 59  ? -2.85967  11.20889  20.75089  1.000 30.60555 ? 95  ARG E CB  1 
ATOM   1573 C  CG  . ARG B 1 59  ? -1.78727  10.30299  21.35880  1.000 40.81812 ? 95  ARG E CG  1 
ATOM   1574 C  CD  . ARG B 1 59  ? -2.41016  9.33046   22.39321  1.000 51.22281 ? 95  ARG E CD  1 
ATOM   1575 N  NE  . ARG B 1 59  ? -2.63850  9.99944   23.67429  1.000 58.95347 ? 95  ARG E NE  1 
ATOM   1576 C  CZ  . ARG B 1 59  ? -1.68378  10.39843  24.51160  1.000 54.63636 ? 95  ARG E CZ  1 
ATOM   1577 N  NH1 . ARG B 1 59  ? -0.40680  10.09196  24.30971  1.000 50.60957 ? 95  ARG E NH1 1 
ATOM   1578 N  NH2 . ARG B 1 59  ? -2.01998  11.13169  25.57289  1.000 51.79893 ? 95  ARG E NH2 1 
ATOM   1579 N  N   . ALA B 1 60  ? -2.74749  11.31634  17.55100  1.000 22.17218 ? 96  ALA E N   1 
ATOM   1580 C  CA  . ALA B 1 60  ? -2.32348  10.60955  16.33363  1.000 24.74036 ? 96  ALA E CA  1 
ATOM   1581 C  C   . ALA B 1 60  ? -1.40116  11.48671  15.50806  1.000 26.28479 ? 96  ALA E C   1 
ATOM   1582 O  O   . ALA B 1 60  ? -0.46866  11.00697  14.85355  1.000 22.60757 ? 96  ALA E O   1 
ATOM   1583 C  CB  . ALA B 1 60  ? -3.51954  10.22998  15.46476  1.000 25.00132 ? 96  ALA E CB  1 
ATOM   1584 N  N   . GLU B 1 61  ? -1.69988  12.77288  15.47003  1.000 23.84445 ? 97  GLU E N   1 
ATOM   1585 C  CA  . GLU B 1 61  ? -0.84100  13.67891  14.70931  1.000 19.21760 ? 97  GLU E CA  1 
ATOM   1586 C  C   . GLU B 1 61  ? 0.52233   13.83007  15.38867  1.000 18.12985 ? 97  GLU E C   1 
ATOM   1587 O  O   . GLU B 1 61  ? 1.55097   13.90174  14.70368  1.000 18.21261 ? 97  GLU E O   1 
ATOM   1588 C  CB  . GLU B 1 61  ? -1.56503  15.01695  14.54305  1.000 18.70261 ? 97  GLU E CB  1 
ATOM   1589 C  CG  . GLU B 1 61  ? -0.88985  15.85797  13.42544  1.000 15.88007 ? 97  GLU E CG  1 
ATOM   1590 C  CD  . GLU B 1 61  ? -1.56645  17.21428  13.24624  1.000 17.37216 ? 97  GLU E CD  1 
ATOM   1591 O  OE1 . GLU B 1 61  ? -2.38232  17.62492  14.11332  1.000 20.68578 ? 97  GLU E OE1 1 
ATOM   1592 O  OE2 . GLU B 1 61  ? -1.24862  17.86611  12.24846  1.000 17.48422 ? 97  GLU E OE2 1 
ATOM   1593 N  N   . GLN B 1 62  ? 0.55604   13.87128  16.73670  1.000 18.53302 ? 98  GLN E N   1 
ATOM   1594 C  CA  . GLN B 1 62  ? 1.83691   13.84620  17.46189  1.000 19.94318 ? 98  GLN E CA  1 
ATOM   1595 C  C   . GLN B 1 62  ? 2.64670   12.58614  17.15051  1.000 19.77760 ? 98  GLN E C   1 
ATOM   1596 O  O   . GLN B 1 62  ? 3.89696   12.62393  17.02561  1.000 19.92580 ? 98  GLN E O   1 
ATOM   1597 C  CB  . GLN B 1 62  ? 1.60442   13.93263  18.97446  1.000 20.11867 ? 98  GLN E CB  1 
ATOM   1598 C  CG  . GLN B 1 62  ? 2.87574   13.81966  19.78039  1.000 20.30877 ? 98  GLN E CG  1 
ATOM   1599 C  CD  . GLN B 1 62  ? 3.87137   14.97723  19.49634  1.000 18.29118 ? 98  GLN E CD  1 
ATOM   1600 O  OE1 . GLN B 1 62  ? 3.46119   16.05667  19.05775  1.000 17.68425 ? 98  GLN E OE1 1 
ATOM   1601 N  NE2 . GLN B 1 62  ? 5.19635   14.73586  19.77487  1.000 17.21455 ? 98  GLN E NE2 1 
ATOM   1602 N  N   . ALA B 1 63  ? 1.96835   11.43128  17.08676  1.000 17.42134 ? 99  ALA E N   1 
ATOM   1603 C  CA  . ALA B 1 63  ? 2.68989   10.20900  16.79346  1.000 19.75047 ? 99  ALA E CA  1 
ATOM   1604 C  C   . ALA B 1 63  ? 3.24069   10.21817  15.37601  1.000 17.11577 ? 99  ALA E C   1 
ATOM   1605 O  O   . ALA B 1 63  ? 4.36756   9.73391   15.14831  1.000 20.22093 ? 99  ALA E O   1 
ATOM   1606 C  CB  . ALA B 1 63  ? 1.76892   8.99464   16.98099  1.000 19.26534 ? 99  ALA E CB  1 
ATOM   1607 N  N   . PHE B 1 64  ? 2.43547   10.70683  14.42257  1.000 19.29868 ? 100 PHE E N   1 
ATOM   1608 C  CA  . PHE B 1 64  ? 2.86028   10.92095  13.04149  1.000 19.38189 ? 100 PHE E CA  1 
ATOM   1609 C  C   . PHE B 1 64  ? 4.12986   11.76643  13.01196  1.000 18.86942 ? 100 PHE E C   1 
ATOM   1610 O  O   . PHE B 1 64  ? 5.11983   11.40545  12.36431  1.000 19.71991 ? 100 PHE E O   1 
ATOM   1611 C  CB  . PHE B 1 64  ? 1.65005   11.54311  12.26815  1.000 17.59688 ? 100 PHE E CB  1 
ATOM   1612 C  CG  . PHE B 1 64  ? 1.94875   12.16866  10.92324  1.000 15.46095 ? 100 PHE E CG  1 
ATOM   1613 C  CD1 . PHE B 1 64  ? 2.16720   11.36912  9.77356   1.000 16.34944 ? 100 PHE E CD1 1 
ATOM   1614 C  CD2 . PHE B 1 64  ? 1.94401   13.56971  10.78939  1.000 16.65811 ? 100 PHE E CD2 1 
ATOM   1615 C  CE1 . PHE B 1 64  ? 2.40461   11.96406  8.54141   1.000 19.10480 ? 100 PHE E CE1 1 
ATOM   1616 C  CE2 . PHE B 1 64  ? 2.14098   14.20205  9.56753   1.000 16.68031 ? 100 PHE E CE2 1 
ATOM   1617 C  CZ  . PHE B 1 64  ? 2.40844   13.36242  8.40613   1.000 16.44940 ? 100 PHE E CZ  1 
ATOM   1618 N  N   . LEU B 1 65  ? 4.13156   12.86423  13.77565  1.000 16.18785 ? 101 LEU E N   1 
ATOM   1619 C  CA  . LEU B 1 65  ? 5.27370   13.77979  13.85173  1.000 15.14404 ? 101 LEU E CA  1 
ATOM   1620 C  C   . LEU B 1 65  ? 6.49621   13.08850  14.44320  1.000 17.12228 ? 101 LEU E C   1 
ATOM   1621 O  O   . LEU B 1 65  ? 7.58761   13.15572  13.88511  1.000 18.15440 ? 101 LEU E O   1 
ATOM   1622 C  CB  . LEU B 1 65  ? 4.86718   14.98917  14.70301  1.000 16.25259 ? 101 LEU E CB  1 
ATOM   1623 C  CG  . LEU B 1 65  ? 5.97991   15.96288  15.12259  1.000 17.80808 ? 101 LEU E CG  1 
ATOM   1624 C  CD1 . LEU B 1 65  ? 6.57228   16.66535  13.89143  1.000 17.72360 ? 101 LEU E CD1 1 
ATOM   1625 C  CD2 . LEU B 1 65  ? 5.48062   17.01549  16.12807  1.000 15.34235 ? 101 LEU E CD2 1 
ATOM   1626 N  N   . GLU B 1 66  ? 6.31438   12.37929  15.55903  1.000 18.85162 ? 102 GLU E N   1 
ATOM   1627 C  CA  . GLU B 1 66  ? 7.41471   11.72908  16.26465  1.000 19.04197 ? 102 GLU E CA  1 
ATOM   1628 C  C   . GLU B 1 66  ? 8.07850   10.65575  15.38354  1.000 18.15475 ? 102 GLU E C   1 
ATOM   1629 O  O   . GLU B 1 66  ? 9.28341   10.39638  15.48765  1.000 18.65888 ? 102 GLU E O   1 
ATOM   1630 C  CB  . GLU B 1 66  ? 6.83283   11.08300  17.54545  1.000 21.40737 ? 102 GLU E CB  1 
ATOM   1631 C  CG  . GLU B 1 66  ? 7.88166   10.91436  18.66251  1.000 34.42789 ? 102 GLU E CG  1 
ATOM   1632 C  CD  . GLU B 1 66  ? 7.38594   11.22113  20.09297  1.000 44.16954 ? 102 GLU E CD  1 
ATOM   1633 O  OE1 . GLU B 1 66  ? 7.75548   10.40795  20.96386  1.000 52.49870 ? 102 GLU E OE1 1 
ATOM   1634 O  OE2 . GLU B 1 66  ? 6.62269   12.19129  20.36186  1.000 50.50827 ? 102 GLU E OE2 1 
ATOM   1635 N  N   . ASN B 1 67  ? 7.30524   10.02404  14.52700  1.000 19.47577 ? 103 ASN E N   1 
ATOM   1636 C  CA  . ASN B 1 67  ? 7.82617   8.85868   13.80324  1.000 20.79686 ? 103 ASN E CA  1 
ATOM   1637 C  C   . ASN B 1 67  ? 8.78698   9.24825   12.67682  1.000 19.98551 ? 103 ASN E C   1 
ATOM   1638 O  O   . ASN B 1 67  ? 9.41836   8.36055   12.06063  1.000 20.33227 ? 103 ASN E O   1 
ATOM   1639 C  CB  . ASN B 1 67  ? 6.63019   8.04227   13.30919  1.000 18.95035 ? 103 ASN E CB  1 
ATOM   1640 C  CG  . ASN B 1 67  ? 7.03817   6.64870   12.79282  1.000 22.52577 ? 103 ASN E CG  1 
ATOM   1641 O  OD1 . ASN B 1 67  ? 7.84099   5.90720   13.44996  1.000 20.87911 ? 103 ASN E OD1 1 
ATOM   1642 N  ND2 . ASN B 1 67  ? 6.54568   6.30840   11.59047  1.000 21.29241 ? 103 ASN E ND2 1 
ATOM   1643 N  N   . PHE B 1 68  ? 8.90480   10.56008  12.34496  1.000 17.17323 ? 104 PHE E N   1 
ATOM   1644 C  CA  . PHE B 1 68  ? 9.88372   10.95077  11.33885  1.000 18.08807 ? 104 PHE E CA  1 
ATOM   1645 C  C   . PHE B 1 68  ? 11.28901  10.95131  11.91443  1.000 19.32246 ? 104 PHE E C   1 
ATOM   1646 O  O   . PHE B 1 68  ? 12.23113  11.04532  11.12755  1.000 18.91347 ? 104 PHE E O   1 
ATOM   1647 C  CB  . PHE B 1 68  ? 9.51877   12.31284  10.70856  1.000 15.67879 ? 104 PHE E CB  1 
ATOM   1648 C  CG  . PHE B 1 68  ? 8.26480   12.19535  9.85246   1.000 17.01865 ? 104 PHE E CG  1 
ATOM   1649 C  CD1 . PHE B 1 68  ? 8.26925   11.27692  8.77190   1.000 17.13176 ? 104 PHE E CD1 1 
ATOM   1650 C  CD2 . PHE B 1 68  ? 7.09098   12.89992  10.16652  1.000 16.30707 ? 104 PHE E CD2 1 
ATOM   1651 C  CE1 . PHE B 1 68  ? 7.09049   11.02498  7.97715   1.000 16.08996 ? 104 PHE E CE1 1 
ATOM   1652 C  CE2 . PHE B 1 68  ? 5.95460   12.74321  9.35067   1.000 17.28985 ? 104 PHE E CE2 1 
ATOM   1653 C  CZ  . PHE B 1 68  ? 5.94818   11.81888  8.26934   1.000 15.71045 ? 104 PHE E CZ  1 
ATOM   1654 N  N   . LYS B 1 69  ? 11.40836  10.82900  13.24767  1.000 17.84681 ? 105 LYS E N   1 
ATOM   1655 C  CA  . LYS B 1 69  ? 12.70503  10.65565  13.93531  1.000 19.55453 ? 105 LYS E CA  1 
ATOM   1656 C  C   . LYS B 1 69  ? 13.63844  11.79752  13.54905  1.000 21.45013 ? 105 LYS E C   1 
ATOM   1657 O  O   . LYS B 1 69  ? 14.79267  11.60723  13.14757  1.000 19.39052 ? 105 LYS E O   1 
ATOM   1658 C  CB  . LYS B 1 69  ? 13.32042  9.28529   13.59276  1.000 21.99647 ? 105 LYS E CB  1 
ATOM   1659 C  CG  . LYS B 1 69  ? 12.61585  8.10720   14.32071  1.000 25.01922 ? 105 LYS E CG  1 
ATOM   1660 C  CD  . LYS B 1 69  ? 13.02157  6.70615   13.74478  1.000 22.62673 ? 105 LYS E CD  1 
ATOM   1661 C  CE  . LYS B 1 69  ? 12.16999  6.27203   12.55450  1.000 24.49107 ? 105 LYS E CE  1 
ATOM   1662 N  NZ  . LYS B 1 69  ? 10.70356  6.04999   12.99780  1.000 19.68648 ? 105 LYS E NZ  1 
ATOM   1663 N  N   . MET B 1 70  ? 13.08573  13.00054  13.59245  1.000 19.69077 ? 106 MET E N   1 
ATOM   1664 C  CA  A MET B 1 70  ? 13.73913  14.18488  13.05874  0.191 18.73767 ? 106 MET E CA  1 
ATOM   1665 C  CA  B MET B 1 70  ? 13.72665  14.18717  13.04610  0.809 18.69057 ? 106 MET E CA  1 
ATOM   1666 C  C   . MET B 1 70  ? 13.46150  15.33052  14.00511  1.000 17.62340 ? 106 MET E C   1 
ATOM   1667 O  O   . MET B 1 70  ? 12.33264  15.48464  14.46709  1.000 19.78848 ? 106 MET E O   1 
ATOM   1668 C  CB  A MET B 1 70  ? 13.19714  14.57813  11.68110  0.191 18.28749 ? 106 MET E CB  1 
ATOM   1669 C  CB  B MET B 1 70  ? 13.13613  14.53778  11.66195  0.809 18.29515 ? 106 MET E CB  1 
ATOM   1670 C  CG  A MET B 1 70  ? 13.65436  13.74738  10.51681  0.191 20.26003 ? 106 MET E CG  1 
ATOM   1671 C  CG  B MET B 1 70  ? 13.92272  15.57189  10.88768  0.809 18.07107 ? 106 MET E CG  1 
ATOM   1672 S  SD  A MET B 1 70  ? 12.80733  14.40911  9.07630   0.191 20.74860 ? 106 MET E SD  1 
ATOM   1673 S  SD  B MET B 1 70  ? 13.13040  15.81044  9.30540   0.809 25.02104 ? 106 MET E SD  1 
ATOM   1674 C  CE  A MET B 1 70  ? 13.53880  16.04996  9.05336   0.191 21.12360 ? 106 MET E CE  1 
ATOM   1675 C  CE  B MET B 1 70  ? 13.40098  14.20556  8.49085   0.809 20.59763 ? 106 MET E CE  1 
ATOM   1676 N  N   . THR B 1 71  ? 14.48378  16.11353  14.30706  1.000 16.56625 ? 107 THR E N   1 
ATOM   1677 C  CA  . THR B 1 71  ? 14.22635  17.32910  15.08924  1.000 15.04049 ? 107 THR E CA  1 
ATOM   1678 C  C   . THR B 1 71  ? 13.63330  18.36710  14.14228  1.000 13.91419 ? 107 THR E C   1 
ATOM   1679 O  O   . THR B 1 71  ? 14.25175  18.70565  13.11055  1.000 15.46591 ? 107 THR E O   1 
ATOM   1680 C  CB  . THR B 1 71  ? 15.51134  17.83982  15.71477  1.000 18.01000 ? 107 THR E CB  1 
ATOM   1681 O  OG1 . THR B 1 71  ? 16.05618  16.77159  16.48876  1.000 18.95724 ? 107 THR E OG1 1 
ATOM   1682 C  CG2 . THR B 1 71  ? 15.18352  19.06769  16.60986  1.000 15.24516 ? 107 THR E CG2 1 
ATOM   1683 N  N   . LEU B 1 72  ? 12.42225  18.83121  14.46073  1.000 12.00162 ? 108 LEU E N   1 
ATOM   1684 C  CA  . LEU B 1 72  ? 11.64898  19.72462  13.61006  1.000 11.88896 ? 108 LEU E CA  1 
ATOM   1685 C  C   . LEU B 1 72  ? 11.11598  20.91000  14.40499  1.000 11.69534 ? 108 LEU E C   1 
ATOM   1686 O  O   . LEU B 1 72  ? 10.55707  20.71143  15.47825  1.000 13.34766 ? 108 LEU E O   1 
ATOM   1687 C  CB  . LEU B 1 72  ? 10.41588  18.98476  13.02932  1.000 11.06587 ? 108 LEU E CB  1 
ATOM   1688 C  CG  . LEU B 1 72  ? 10.82982  17.93557  12.02016  1.000 13.60774 ? 108 LEU E CG  1 
ATOM   1689 C  CD1 . LEU B 1 72  ? 9.68192   16.96148  11.74718  1.000 12.52913 ? 108 LEU E CD1 1 
ATOM   1690 C  CD2 . LEU B 1 72  ? 11.22149  18.70608  10.69175  1.000 12.50735 ? 108 LEU E CD2 1 
ATOM   1691 N  N   . TRP B 1 73  ? 11.25320  22.14257  13.86804  1.000 12.86389 ? 109 TRP E N   1 
ATOM   1692 C  CA  . TRP B 1 73  ? 10.45082  23.24164  14.39455  1.000 12.30288 ? 109 TRP E CA  1 
ATOM   1693 C  C   . TRP B 1 73  ? 8.97723   22.93867  14.13399  1.000 11.00883 ? 109 TRP E C   1 
ATOM   1694 O  O   . TRP B 1 73  ? 8.62900   22.47524  13.05030  1.000 11.50943 ? 109 TRP E O   1 
ATOM   1695 C  CB  . TRP B 1 73  ? 10.76368  24.57327  13.66985  1.000 11.04887 ? 109 TRP E CB  1 
ATOM   1696 C  CG  . TRP B 1 73  ? 12.03226  25.21929  14.02347  1.000 11.46324 ? 109 TRP E CG  1 
ATOM   1697 C  CD1 . TRP B 1 73  ? 12.98548  25.69746  13.13295  1.000 12.38492 ? 109 TRP E CD1 1 
ATOM   1698 C  CD2 . TRP B 1 73  ? 12.47222  25.61971  15.34403  1.000 8.76482  ? 109 TRP E CD2 1 
ATOM   1699 N  NE1 . TRP B 1 73  ? 14.00493  26.31022  13.83651  1.000 11.90565 ? 109 TRP E NE1 1 
ATOM   1700 C  CE2 . TRP B 1 73  ? 13.71560  26.27850  15.17947  1.000 12.23038 ? 109 TRP E CE2 1 
ATOM   1701 C  CE3 . TRP B 1 73  ? 11.97487  25.40419  16.65688  1.000 10.03961 ? 109 TRP E CE3 1 
ATOM   1702 C  CZ2 . TRP B 1 73  ? 14.44670  26.77063  16.25800  1.000 10.98214 ? 109 TRP E CZ2 1 
ATOM   1703 C  CZ3 . TRP B 1 73  ? 12.72868  25.92745  17.76278  1.000 11.23026 ? 109 TRP E CZ3 1 
ATOM   1704 C  CH2 . TRP B 1 73  ? 13.93460  26.62446  17.51070  1.000 12.87925 ? 109 TRP E CH2 1 
ATOM   1705 N  N   . ILE B 1 74  ? 8.10766   23.24566  15.09256  1.000 10.33295 ? 110 ILE E N   1 
ATOM   1706 C  CA  . ILE B 1 74  ? 6.68299   23.17345  14.85213  1.000 11.16582 ? 110 ILE E CA  1 
ATOM   1707 C  C   . ILE B 1 74  ? 6.07785   24.50318  15.25144  1.000 12.48260 ? 110 ILE E C   1 
ATOM   1708 O  O   . ILE B 1 74  ? 6.75686   25.37346  15.78457  1.000 12.09495 ? 110 ILE E O   1 
ATOM   1709 C  CB  . ILE B 1 74  ? 6.04960   21.98210  15.60907  1.000 11.47279 ? 110 ILE E CB  1 
ATOM   1710 C  CG1 . ILE B 1 74  ? 6.17095   22.20244  17.11945  1.000 12.16422 ? 110 ILE E CG1 1 
ATOM   1711 C  CG2 . ILE B 1 74  ? 6.73264   20.65977  15.07437  1.000 13.04062 ? 110 ILE E CG2 1 
ATOM   1712 C  CD1 . ILE B 1 74  ? 5.50999   21.10244  17.98430  1.000 13.99409 ? 110 ILE E CD1 1 
ATOM   1713 N  N   . GLY B 1 75  ? 4.78364   24.66136  14.96228  1.000 11.70298 ? 111 GLY E N   1 
ATOM   1714 C  CA  . GLY B 1 75  ? 4.19209   26.00503  15.00668  1.000 13.00416 ? 111 GLY E CA  1 
ATOM   1715 C  C   . GLY B 1 75  ? 3.62198   26.36293  16.35534  1.000 14.18773 ? 111 GLY E C   1 
ATOM   1716 O  O   . GLY B 1 75  ? 2.44258   26.71070  16.44602  1.000 13.74330 ? 111 GLY E O   1 
ATOM   1717 N  N   . LEU B 1 76  ? 4.45031   26.26793  17.41082  1.000 12.24241 ? 112 LEU E N   1 
ATOM   1718 C  CA  . LEU B 1 76  ? 4.05658   26.63974  18.76661  1.000 13.42606 ? 112 LEU E CA  1 
ATOM   1719 C  C   . LEU B 1 76  ? 5.09667   27.61292  19.27811  1.000 14.68960 ? 112 LEU E C   1 
ATOM   1720 O  O   . LEU B 1 76  ? 6.31630   27.36697  19.11409  1.000 14.74121 ? 112 LEU E O   1 
ATOM   1721 C  CB  . LEU B 1 76  ? 4.00673   25.40235  19.66575  1.000 12.75669 ? 112 LEU E CB  1 
ATOM   1722 C  CG  . LEU B 1 76  ? 3.40511   25.56520  21.08532  1.000 15.84609 ? 112 LEU E CG  1 
ATOM   1723 C  CD1 . LEU B 1 76  ? 1.85889   26.02682  21.07106  1.000 14.50280 ? 112 LEU E CD1 1 
ATOM   1724 C  CD2 . LEU B 1 76  ? 3.50656   24.21330  21.79740  1.000 13.71734 ? 112 LEU E CD2 1 
ATOM   1725 N  N   . MET B 1 77  ? 4.63389   28.69921  19.91420  1.000 13.18050 ? 113 MET E N   1 
ATOM   1726 C  CA  . MET B 1 77  ? 5.54791   29.77359  20.30644  1.000 14.39953 ? 113 MET E CA  1 
ATOM   1727 C  C   . MET B 1 77  ? 5.04257   30.43055  21.59168  1.000 14.63430 ? 113 MET E C   1 
ATOM   1728 O  O   . MET B 1 77  ? 3.84060   30.53354  21.82798  1.000 15.50379 ? 113 MET E O   1 
ATOM   1729 C  CB  . MET B 1 77  ? 5.70212   30.87040  19.23648  1.000 16.64824 ? 113 MET E CB  1 
ATOM   1730 C  CG  . MET B 1 77  ? 6.87800   31.84231  19.65927  1.000 19.10419 ? 113 MET E CG  1 
ATOM   1731 S  SD  . MET B 1 77  ? 7.18104   33.08929  18.37559  1.000 28.35805 ? 113 MET E SD  1 
ATOM   1732 C  CE  . MET B 1 77  ? 5.59960   33.74013  18.25515  1.000 26.60577 ? 113 MET E CE  1 
ATOM   1733 N  N   . GLU B 1 78  ? 5.97143   30.83857  22.44165  1.000 13.68752 ? 114 GLU E N   1 
ATOM   1734 C  CA  . GLU B 1 78  ? 5.56768   31.38705  23.74928  1.000 14.11234 ? 114 GLU E CA  1 
ATOM   1735 C  C   . GLU B 1 78  ? 4.91639   32.74864  23.53134  1.000 16.67104 ? 114 GLU E C   1 
ATOM   1736 O  O   . GLU B 1 78  ? 5.26918   33.45800  22.58640  1.000 17.61096 ? 114 GLU E O   1 
ATOM   1737 C  CB  . GLU B 1 78  ? 6.85185   31.54625  24.60656  1.000 14.64136 ? 114 GLU E CB  1 
ATOM   1738 C  CG  . GLU B 1 78  ? 6.62845   31.88651  26.08862  1.000 16.81194 ? 114 GLU E CG  1 
ATOM   1739 C  CD  . GLU B 1 78  ? 7.96638   31.93251  26.86455  1.000 16.85254 ? 114 GLU E CD  1 
ATOM   1740 O  OE1 . GLU B 1 78  ? 9.06585   31.72088  26.26277  1.000 18.52057 ? 114 GLU E OE1 1 
ATOM   1741 O  OE2 . GLU B 1 78  ? 7.88741   32.13420  28.09905  1.000 15.79761 ? 114 GLU E OE2 1 
ATOM   1742 N  N   . GLN B 1 79  ? 3.97924   33.13960  24.42352  1.000 17.38550 ? 115 GLN E N   1 
ATOM   1743 C  CA  . GLN B 1 79  ? 3.46333   34.51222  24.43277  1.000 19.68811 ? 115 GLN E CA  1 
ATOM   1744 C  C   . GLN B 1 79  ? 4.45904   35.35546  25.22537  1.000 21.22956 ? 115 GLN E C   1 
ATOM   1745 O  O   . GLN B 1 79  ? 4.54963   35.21693  26.44263  1.000 21.44036 ? 115 GLN E O   1 
ATOM   1746 C  CB  . GLN B 1 79  ? 2.06541   34.51997  25.03461  1.000 19.05712 ? 115 GLN E CB  1 
ATOM   1747 C  CG  . GLN B 1 79  ? 1.15809   33.52616  24.27192  1.000 25.01263 ? 115 GLN E CG  1 
ATOM   1748 C  CD  . GLN B 1 79  ? -0.30543  33.44880  24.74657  1.000 31.16467 ? 115 GLN E CD  1 
ATOM   1749 O  OE1 . GLN B 1 79  ? -1.20506  34.10586  24.18933  1.000 36.26601 ? 115 GLN E OE1 1 
ATOM   1750 N  NE2 . GLN B 1 79  ? -0.55335  32.59402  25.74365  1.000 31.08983 ? 115 GLN E NE2 1 
ATOM   1751 N  N   . ARG B 1 80  ? 5.29271   36.13408  24.53019  1.000 22.27893 ? 116 ARG E N   1 
ATOM   1752 C  CA  . ARG B 1 80  ? 6.32063   37.00875  25.13743  1.000 23.24768 ? 116 ARG E CA  1 
ATOM   1753 C  C   . ARG B 1 80  ? 7.22494   36.14331  26.01082  1.000 23.10712 ? 116 ARG E C   1 
ATOM   1754 O  O   . ARG B 1 80  ? 7.78107   35.14178  25.51468  1.000 21.29710 ? 116 ARG E O   1 
ATOM   1755 C  CB  . ARG B 1 80  ? 5.60113   38.15715  25.88080  1.000 26.72784 ? 116 ARG E CB  1 
ATOM   1756 C  CG  . ARG B 1 80  ? 4.48640   38.86056  25.04924  1.000 38.01727 ? 116 ARG E CG  1 
ATOM   1757 C  CD  . ARG B 1 80  ? 3.96675   40.01261  25.85326  1.000 47.13155 ? 116 ARG E CD  1 
ATOM   1758 N  NE  . ARG B 1 80  ? 2.87430   39.56056  26.71848  1.000 48.50605 ? 116 ARG E NE  1 
ATOM   1759 C  CZ  . ARG B 1 80  ? 2.71164   39.97880  27.96985  1.000 49.91353 ? 116 ARG E CZ  1 
ATOM   1760 N  NH1 . ARG B 1 80  ? 3.65457   40.68082  28.59002  1.000 45.27821 ? 116 ARG E NH1 1 
ATOM   1761 N  NH2 . ARG B 1 80  ? 1.60664   39.63977  28.63332  1.000 49.39721 ? 116 ARG E NH2 1 
ATOM   1762 N  N   . SER B 1 81  ? 7.38813   36.47279  27.29040  1.000 21.53238 ? 117 SER E N   1 
ATOM   1763 C  CA  . SER B 1 81  ? 8.16402   35.68205  28.23755  1.000 19.95994 ? 117 SER E CA  1 
ATOM   1764 C  C   . SER B 1 81  ? 7.25039   35.04414  29.27268  1.000 20.05837 ? 117 SER E C   1 
ATOM   1765 O  O   . SER B 1 81  ? 7.72497   34.63350  30.32663  1.000 18.79855 ? 117 SER E O   1 
ATOM   1766 C  CB  . SER B 1 81  ? 9.23091   36.53627  28.95059  1.000 23.03051 ? 117 SER E CB  1 
ATOM   1767 O  OG  . SER B 1 81  ? 10.17611  37.05291  28.02165  1.000 26.55827 ? 117 SER E OG  1 
ATOM   1768 N  N   . GLU B 1 82  ? 5.96694   34.85234  28.94102  1.000 19.57983 ? 118 GLU E N   1 
ATOM   1769 C  CA  . GLU B 1 82  ? 4.98617   34.48054  29.95589  1.000 20.46250 ? 118 GLU E CA  1 
ATOM   1770 C  C   . GLU B 1 82  ? 4.90871   32.98699  30.26005  1.000 18.33372 ? 118 GLU E C   1 
ATOM   1771 O  O   . GLU B 1 82  ? 4.14813   32.61503  31.17450  1.000 16.82351 ? 118 GLU E O   1 
ATOM   1772 C  CB  . GLU B 1 82  ? 3.60550   34.94660  29.51952  1.000 21.04110 ? 118 GLU E CB  1 
ATOM   1773 C  CG  . GLU B 1 82  ? 3.46411   36.47058  29.46570  1.000 23.39008 ? 118 GLU E CG  1 
ATOM   1774 C  CD  . GLU B 1 82  ? 3.59751   37.09920  30.85298  1.000 28.32170 ? 118 GLU E CD  1 
ATOM   1775 O  OE1 . GLU B 1 82  ? 2.62528   36.98788  31.61237  1.000 30.53901 ? 118 GLU E OE1 1 
ATOM   1776 O  OE2 . GLU B 1 82  ? 4.65640   37.63699  31.21346  1.000 26.93277 ? 118 GLU E OE2 1 
ATOM   1777 N  N   . ARG B 1 83  ? 5.62485   32.12349  29.52590  1.000 16.31311 ? 119 ARG E N   1 
ATOM   1778 C  CA  . ARG B 1 83  ? 5.55116   30.68218  29.77072  1.000 16.04480 ? 119 ARG E CA  1 
ATOM   1779 C  C   . ARG B 1 83  ? 4.13516   30.19713  29.58093  1.000 16.61233 ? 119 ARG E C   1 
ATOM   1780 O  O   . ARG B 1 83  ? 3.68542   29.25734  30.24399  1.000 18.62324 ? 119 ARG E O   1 
ATOM   1781 C  CB  . ARG B 1 83  ? 6.08192   30.28666  31.16742  1.000 15.06387 ? 119 ARG E CB  1 
ATOM   1782 C  CG  . ARG B 1 83  ? 7.54319   30.82730  31.39778  1.000 14.93945 ? 119 ARG E CG  1 
ATOM   1783 C  CD  . ARG B 1 83  ? 8.59874   29.80787  30.89157  1.000 15.56346 ? 119 ARG E CD  1 
ATOM   1784 N  NE  . ARG B 1 83  ? 8.88688   29.88771  29.44587  1.000 14.03811 ? 119 ARG E NE  1 
ATOM   1785 C  CZ  . ARG B 1 83  ? 9.64351   28.99025  28.84737  1.000 13.62042 ? 119 ARG E CZ  1 
ATOM   1786 N  NH1 . ARG B 1 83  ? 10.06863  27.91487  29.51546  1.000 14.22545 ? 119 ARG E NH1 1 
ATOM   1787 N  NH2 . ARG B 1 83  ? 9.95894   29.14551  27.54539  1.000 14.92469 ? 119 ARG E NH2 1 
ATOM   1788 N  N   . THR B 1 84  ? 3.40342   30.84925  28.66201  1.000 17.58289 ? 120 THR E N   1 
ATOM   1789 C  CA  . THR B 1 84  ? 2.16158   30.28743  28.12498  1.000 15.76276 ? 120 THR E CA  1 
ATOM   1790 C  C   . THR B 1 84  ? 2.38616   30.21646  26.61921  1.000 16.34346 ? 120 THR E C   1 
ATOM   1791 O  O   . THR B 1 84  ? 3.27670   30.90182  26.09410  1.000 15.17438 ? 120 THR E O   1 
ATOM   1792 C  CB  . THR B 1 84  ? 0.92029   31.14541  28.43226  1.000 16.97652 ? 120 THR E CB  1 
ATOM   1793 O  OG1 . THR B 1 84  ? 1.11856   32.45606  27.87045  1.000 22.44369 ? 120 THR E OG1 1 
ATOM   1794 C  CG2 . THR B 1 84  ? 0.71820   31.23842  29.97035  1.000 21.63250 ? 120 THR E CG2 1 
ATOM   1795 N  N   . TRP B 1 85  ? 1.57477   29.41734  25.92706  1.000 15.83647 ? 121 TRP E N   1 
ATOM   1796 C  CA  . TRP B 1 85  ? 1.94285   29.00330  24.55928  1.000 16.08208 ? 121 TRP E CA  1 
ATOM   1797 C  C   . TRP B 1 85  ? 0.72825   29.10118  23.64725  1.000 19.60513 ? 121 TRP E C   1 
ATOM   1798 O  O   . TRP B 1 85  ? -0.38692  28.82501  24.08005  1.000 19.00158 ? 121 TRP E O   1 
ATOM   1799 C  CB  . TRP B 1 85  ? 2.40992   27.52673  24.58275  1.000 14.41318 ? 121 TRP E CB  1 
ATOM   1800 C  CG  . TRP B 1 85  ? 3.59590   27.39223  25.56449  1.000 14.90765 ? 121 TRP E CG  1 
ATOM   1801 C  CD1 . TRP B 1 85  ? 3.54226   27.14767  26.90139  1.000 14.70451 ? 121 TRP E CD1 1 
ATOM   1802 C  CD2 . TRP B 1 85  ? 4.98395   27.59106  25.23225  1.000 16.01572 ? 121 TRP E CD2 1 
ATOM   1803 N  NE1 . TRP B 1 85  ? 4.83012   27.11872  27.44444  1.000 14.72723 ? 121 TRP E NE1 1 
ATOM   1804 C  CE2 . TRP B 1 85  ? 5.72951   27.40196  26.42997  1.000 15.60448 ? 121 TRP E CE2 1 
ATOM   1805 C  CE3 . TRP B 1 85  ? 5.66455   27.90777  24.04577  1.000 15.49221 ? 121 TRP E CE3 1 
ATOM   1806 C  CZ2 . TRP B 1 85  ? 7.12092   27.55328  26.47154  1.000 17.00923 ? 121 TRP E CZ2 1 
ATOM   1807 C  CZ3 . TRP B 1 85  ? 7.03896   28.04452  24.06483  1.000 16.66799 ? 121 TRP E CZ3 1 
ATOM   1808 C  CH2 . TRP B 1 85  ? 7.77629   27.85823  25.28681  1.000 15.14463 ? 121 TRP E CH2 1 
ATOM   1809 N  N   . ARG B 1 86  ? 0.96365   29.47646  22.39227  1.000 18.06252 ? 122 ARG E N   1 
ATOM   1810 C  CA  . ARG B 1 86  ? -0.08516  29.66877  21.39723  1.000 19.33045 ? 122 ARG E CA  1 
ATOM   1811 C  C   . ARG B 1 86  ? 0.38241   29.05026  20.08945  1.000 17.67674 ? 122 ARG E C   1 
ATOM   1812 O  O   . ARG B 1 86  ? 1.53176   29.28451  19.69064  1.000 16.33015 ? 122 ARG E O   1 
ATOM   1813 C  CB  . ARG B 1 86  ? -0.34202  31.17340  21.17205  1.000 23.07427 ? 122 ARG E CB  1 
ATOM   1814 C  CG  . ARG B 1 86  ? -1.70171  31.44850  20.53028  1.000 30.51757 ? 122 ARG E CG  1 
ATOM   1815 C  CD  . ARG B 1 86  ? -2.23966  32.83778  20.89406  1.000 34.68684 ? 122 ARG E CD  1 
ATOM   1816 N  NE  . ARG B 1 86  ? -2.62075  32.86392  22.30756  1.000 39.80575 ? 122 ARG E NE  1 
ATOM   1817 C  CZ  . ARG B 1 86  ? -3.86688  32.72435  22.75605  1.000 44.12641 ? 122 ARG E CZ  1 
ATOM   1818 N  NH1 . ARG B 1 86  ? -4.88136  32.49833  21.93051  1.000 39.06932 ? 122 ARG E NH1 1 
ATOM   1819 N  NH2 . ARG B 1 86  ? -4.09375  32.74496  24.07076  1.000 46.25715 ? 122 ARG E NH2 1 
ATOM   1820 N  N   . TRP B 1 87  ? -0.50084  28.31287  19.41254  1.000 17.97482 ? 123 TRP E N   1 
ATOM   1821 C  CA  . TRP B 1 87  ? -0.15224  27.80823  18.08311  1.000 15.52645 ? 123 TRP E CA  1 
ATOM   1822 C  C   . TRP B 1 87  ? -0.19702  28.96820  17.08712  1.000 16.98525 ? 123 TRP E C   1 
ATOM   1823 O  O   . TRP B 1 87  ? -0.82402  30.01917  17.33932  1.000 18.81877 ? 123 TRP E O   1 
ATOM   1824 C  CB  . TRP B 1 87  ? -1.13791  26.68827  17.65449  1.000 16.72515 ? 123 TRP E CB  1 
ATOM   1825 C  CG  . TRP B 1 87  ? -1.08692  25.47888  18.56384  1.000 17.53139 ? 123 TRP E CG  1 
ATOM   1826 C  CD1 . TRP B 1 87  ? -1.92844  25.13850  19.63846  1.000 15.86580 ? 123 TRP E CD1 1 
ATOM   1827 C  CD2 . TRP B 1 87  ? -0.12415  24.42801  18.46641  1.000 17.64339 ? 123 TRP E CD2 1 
ATOM   1828 N  NE1 . TRP B 1 87  ? -1.48157  23.95034  20.20871  1.000 19.53707 ? 123 TRP E NE1 1 
ATOM   1829 C  CE2 . TRP B 1 87  ? -0.39411  23.49424  19.48747  1.000 15.71824 ? 123 TRP E CE2 1 
ATOM   1830 C  CE3 . TRP B 1 87  ? 0.95773   24.19742  17.60034  1.000 14.15910 ? 123 TRP E CE3 1 
ATOM   1831 C  CZ2 . TRP B 1 87  ? 0.38400   22.34759  19.66218  1.000 16.19650 ? 123 TRP E CZ2 1 
ATOM   1832 C  CZ3 . TRP B 1 87  ? 1.74942   23.04940  17.81132  1.000 13.98145 ? 123 TRP E CZ3 1 
ATOM   1833 C  CH2 . TRP B 1 87  ? 1.47176   22.15973  18.81372  1.000 15.57144 ? 123 TRP E CH2 1 
ATOM   1834 N  N   . VAL B 1 88  ? 0.45834   28.77322  15.93230  1.000 15.81922 ? 124 VAL E N   1 
ATOM   1835 C  CA  . VAL B 1 88  ? 0.61129   29.84955  14.96196  1.000 14.68249 ? 124 VAL E CA  1 
ATOM   1836 C  C   . VAL B 1 88  ? -0.75910  30.26042  14.40292  1.000 18.63109 ? 124 VAL E C   1 
ATOM   1837 O  O   . VAL B 1 88  ? -0.85099  31.33728  13.81648  1.000 18.61816 ? 124 VAL E O   1 
ATOM   1838 C  CB  . VAL B 1 88  ? 1.56013   29.47043  13.81562  1.000 15.29843 ? 124 VAL E CB  1 
ATOM   1839 C  CG1 . VAL B 1 88  ? 3.05134   29.45076  14.30628  1.000 14.72807 ? 124 VAL E CG1 1 
ATOM   1840 C  CG2 . VAL B 1 88  ? 1.18717   28.04647  13.30288  1.000 15.60653 ? 124 VAL E CG2 1 
ATOM   1841 N  N   . ASP B 1 89  ? -1.80179  29.41168  14.55345  1.000 19.11611 ? 125 ASP E N   1 
ATOM   1842 C  CA  . ASP B 1 89  ? -3.13939  29.78611  14.08539  1.000 24.48299 ? 125 ASP E CA  1 
ATOM   1843 C  C   . ASP B 1 89  ? -3.89893  30.62695  15.10085  1.000 26.79983 ? 125 ASP E C   1 
ATOM   1844 O  O   . ASP B 1 89  ? -5.01776  31.07892  14.81246  1.000 25.86485 ? 125 ASP E O   1 
ATOM   1845 C  CB  . ASP B 1 89  ? -3.96115  28.55262  13.67627  1.000 22.90339 ? 125 ASP E CB  1 
ATOM   1846 C  CG  . ASP B 1 89  ? -4.41505  27.71470  14.82632  1.000 25.16567 ? 125 ASP E CG  1 
ATOM   1847 O  OD1 . ASP B 1 89  ? -3.95302  27.86671  15.95775  1.000 26.16337 ? 125 ASP E OD1 1 
ATOM   1848 O  OD2 . ASP B 1 89  ? -5.23193  26.81237  14.60016  1.000 28.91468 ? 125 ASP E OD2 1 
ATOM   1849 N  N   . GLY B 1 90  ? -3.30584  30.86313  16.26771  1.000 23.88819 ? 126 GLY E N   1 
ATOM   1850 C  CA  . GLY B 1 90  ? -3.90238  31.66605  17.31052  1.000 25.13936 ? 126 GLY E CA  1 
ATOM   1851 C  C   . GLY B 1 90  ? -4.49453  30.87184  18.45443  1.000 28.88078 ? 126 GLY E C   1 
ATOM   1852 O  O   . GLY B 1 90  ? -4.84891  31.47787  19.47403  1.000 32.77670 ? 126 GLY E O   1 
ATOM   1853 N  N   . THR B 1 91  ? -4.60785  29.54706  18.33220  1.000 26.70162 ? 127 THR E N   1 
ATOM   1854 C  CA  . THR B 1 91  ? -5.25703  28.80060  19.41781  1.000 28.44835 ? 127 THR E CA  1 
ATOM   1855 C  C   . THR B 1 91  ? -4.31758  28.63490  20.61874  1.000 29.61379 ? 127 THR E C   1 
ATOM   1856 O  O   . THR B 1 91  ? -3.11700  28.36397  20.45641  1.000 25.18726 ? 127 THR E O   1 
ATOM   1857 C  CB  . THR B 1 91  ? -5.73487  27.44078  18.91903  1.000 27.02014 ? 127 THR E CB  1 
ATOM   1858 O  OG1 . THR B 1 91  ? -4.68854  26.80427  18.18329  1.000 32.25437 ? 127 THR E OG1 1 
ATOM   1859 C  CG2 . THR B 1 91  ? -6.85730  27.62609  17.96770  1.000 29.88243 ? 127 THR E CG2 1 
ATOM   1860 N  N   . PRO B 1 92  ? -4.81425  28.79913  21.84126  1.000 29.44316 ? 128 PRO E N   1 
ATOM   1861 C  CA  . PRO B 1 92  ? -3.97518  28.49783  23.00685  1.000 29.30196 ? 128 PRO E CA  1 
ATOM   1862 C  C   . PRO B 1 92  ? -3.65462  27.01015  23.05425  1.000 24.41404 ? 128 PRO E C   1 
ATOM   1863 O  O   . PRO B 1 92  ? -4.41716  26.17211  22.56861  1.000 25.86467 ? 128 PRO E O   1 
ATOM   1864 C  CB  . PRO B 1 92  ? -4.85565  28.91082  24.19596  1.000 32.30679 ? 128 PRO E CB  1 
ATOM   1865 C  CG  . PRO B 1 92  ? -6.27033  28.76134  23.64363  1.000 33.80752 ? 128 PRO E CG  1 
ATOM   1866 C  CD  . PRO B 1 92  ? -6.16387  29.23638  22.22683  1.000 33.40487 ? 128 PRO E CD  1 
ATOM   1867 N  N   . LEU B 1 93  ? -2.48688  26.69769  23.61664  1.000 23.39433 ? 129 LEU E N   1 
ATOM   1868 C  CA  . LEU B 1 93  ? -2.10836  25.31636  23.87642  1.000 22.14528 ? 129 LEU E CA  1 
ATOM   1869 C  C   . LEU B 1 93  ? -3.15510  24.62818  24.76147  1.000 26.05221 ? 129 LEU E C   1 
ATOM   1870 O  O   . LEU B 1 93  ? -3.55393  25.16114  25.80791  1.000 22.57520 ? 129 LEU E O   1 
ATOM   1871 C  CB  . LEU B 1 93  ? -0.75191  25.28692  24.57417  1.000 22.76768 ? 129 LEU E CB  1 
ATOM   1872 C  CG  . LEU B 1 93  ? -0.15947  23.92743  24.88823  1.000 20.17996 ? 129 LEU E CG  1 
ATOM   1873 C  CD1 . LEU B 1 93  ? 0.01157   23.16108  23.56412  1.000 20.40011 ? 129 LEU E CD1 1 
ATOM   1874 C  CD2 . LEU B 1 93  ? 1.21591   24.13716  25.53141  1.000 20.68909 ? 129 LEU E CD2 1 
ATOM   1875 N  N   . THR B 1 94  ? -3.60730  23.44735  24.34753  1.000 25.06510 ? 130 THR E N   1 
ATOM   1876 C  CA  . THR B 1 94  ? -4.40619  22.66550  25.27993  1.000 26.81353 ? 130 THR E CA  1 
ATOM   1877 C  C   . THR B 1 94  ? -3.71449  21.35282  25.59091  1.000 25.07557 ? 130 THR E C   1 
ATOM   1878 O  O   . THR B 1 94  ? -2.82130  21.36515  26.43866  1.000 26.08300 ? 130 THR E O   1 
ATOM   1879 C  CB  . THR B 1 94  ? -5.80439  22.43537  24.67848  1.000 26.38459 ? 130 THR E CB  1 
ATOM   1880 O  OG1 . THR B 1 94  ? -5.67025  21.83428  23.37255  1.000 30.40223 ? 130 THR E OG1 1 
ATOM   1881 C  CG2 . THR B 1 94  ? -6.49737  23.73467  24.48435  1.000 26.99475 ? 130 THR E CG2 1 
ATOM   1882 N  N   . GLU B 1 95  ? -3.87603  20.32590  24.75417  1.000 21.26060 ? 131 GLU E N   1 
ATOM   1883 C  CA  . GLU B 1 95  ? -3.16712  19.06025  24.94677  1.000 25.91686 ? 131 GLU E CA  1 
ATOM   1884 C  C   . GLU B 1 95  ? -1.70524  19.27425  24.54865  1.000 22.53843 ? 131 GLU E C   1 
ATOM   1885 O  O   . GLU B 1 95  ? -1.43946  19.96170  23.55519  1.000 21.98199 ? 131 GLU E O   1 
ATOM   1886 C  CB  . GLU B 1 95  ? -3.77605  17.97917  24.06225  1.000 31.47067 ? 131 GLU E CB  1 
ATOM   1887 C  CG  . GLU B 1 95  ? -5.31965  17.97947  24.05734  1.000 42.91366 ? 131 GLU E CG  1 
ATOM   1888 C  CD  . GLU B 1 95  ? -5.92358  16.91159  23.13054  1.000 54.13893 ? 131 GLU E CD  1 
ATOM   1889 O  OE1 . GLU B 1 95  ? -5.54339  16.85371  21.92910  1.000 57.14181 ? 131 GLU E OE1 1 
ATOM   1890 O  OE2 . GLU B 1 95  ? -6.80785  16.15953  23.60249  1.000 58.08358 ? 131 GLU E OE2 1 
ATOM   1891 N  N   . SER B 1 96  ? -0.76369  18.75912  25.34377  1.000 20.80519 ? 132 SER E N   1 
ATOM   1892 C  CA  . SER B 1 96  ? 0.65063   19.05505  25.09479  1.000 21.08982 ? 132 SER E CA  1 
ATOM   1893 C  C   . SER B 1 96  ? 1.48585   17.77653  25.17796  1.000 21.65136 ? 132 SER E C   1 
ATOM   1894 O  O   . SER B 1 96  ? 1.05946   16.76628  25.75658  1.000 21.23355 ? 132 SER E O   1 
ATOM   1895 C  CB  . SER B 1 96  ? 1.16055   20.14121  26.09451  1.000 20.16286 ? 132 SER E CB  1 
ATOM   1896 O  OG  . SER B 1 96  ? 1.17046   19.63118  27.42379  1.000 21.80942 ? 132 SER E OG  1 
ATOM   1897 N  N   . TYR B 1 97  ? 2.67438   17.80143  24.55276  1.000 19.09145 ? 133 TYR E N   1 
ATOM   1898 C  CA  . TYR B 1 97  ? 3.53304   16.62558  24.49310  1.000 20.15468 ? 133 TYR E CA  1 
ATOM   1899 C  C   . TYR B 1 97  ? 4.97879   17.02344  24.80630  1.000 19.29820 ? 133 TYR E C   1 
ATOM   1900 O  O   . TYR B 1 97  ? 5.91963   16.61265  24.13007  1.000 19.51806 ? 133 TYR E O   1 
ATOM   1901 C  CB  . TYR B 1 97  ? 3.41871   15.88960  23.13982  1.000 21.27375 ? 133 TYR E CB  1 
ATOM   1902 C  CG  . TYR B 1 97  ? 1.99564   15.43779  22.84104  1.000 23.11874 ? 133 TYR E CG  1 
ATOM   1903 C  CD1 . TYR B 1 97  ? 1.50933   14.21272  23.31527  1.000 24.08044 ? 133 TYR E CD1 1 
ATOM   1904 C  CD2 . TYR B 1 97  ? 1.12046   16.26099  22.13057  1.000 20.28226 ? 133 TYR E CD2 1 
ATOM   1905 C  CE1 . TYR B 1 97  ? 0.20221   13.82311  23.06986  1.000 26.70829 ? 133 TYR E CE1 1 
ATOM   1906 C  CE2 . TYR B 1 97  ? -0.19730  15.88120  21.89328  1.000 24.53711 ? 133 TYR E CE2 1 
ATOM   1907 C  CZ  . TYR B 1 97  ? -0.64390  14.66282  22.38048  1.000 27.83737 ? 133 TYR E CZ  1 
ATOM   1908 O  OH  . TYR B 1 97  ? -1.95362  14.30919  22.14389  1.000 28.22729 ? 133 TYR E OH  1 
ATOM   1909 N  N   . TRP B 1 98  ? 5.16941   17.79052  25.89035  1.000 19.01993 ? 134 TRP E N   1 
ATOM   1910 C  CA  . TRP B 1 98  ? 6.51119   18.21728  26.26744  1.000 21.91328 ? 134 TRP E CA  1 
ATOM   1911 C  C   . TRP B 1 98  ? 7.36978   17.01154  26.64267  1.000 20.67535 ? 134 TRP E C   1 
ATOM   1912 O  O   . TRP B 1 98  ? 6.90177   16.09628  27.32067  1.000 20.83459 ? 134 TRP E O   1 
ATOM   1913 C  CB  . TRP B 1 98  ? 6.45536   19.16806  27.45794  1.000 18.55945 ? 134 TRP E CB  1 
ATOM   1914 C  CG  . TRP B 1 98  ? 5.74675   20.45435  27.23452  1.000 16.10924 ? 134 TRP E CG  1 
ATOM   1915 C  CD1 . TRP B 1 98  ? 4.51578   20.83575  27.75499  1.000 18.79307 ? 134 TRP E CD1 1 
ATOM   1916 C  CD2 . TRP B 1 98  ? 6.21805   21.56271  26.46049  1.000 17.69316 ? 134 TRP E CD2 1 
ATOM   1917 N  NE1 . TRP B 1 98  ? 4.21063   22.11086  27.32909  1.000 16.64590 ? 134 TRP E NE1 1 
ATOM   1918 C  CE2 . TRP B 1 98  ? 5.22639   22.58044  26.53157  1.000 16.75077 ? 134 TRP E CE2 1 
ATOM   1919 C  CE3 . TRP B 1 98  ? 7.36631   21.77990  25.69045  1.000 16.49926 ? 134 TRP E CE3 1 
ATOM   1920 C  CZ2 . TRP B 1 98  ? 5.35552   23.81722  25.88770  1.000 15.16554 ? 134 TRP E CZ2 1 
ATOM   1921 C  CZ3 . TRP B 1 98  ? 7.49842   23.01591  25.00953  1.000 14.87081 ? 134 TRP E CZ3 1 
ATOM   1922 C  CH2 . TRP B 1 98  ? 6.48925   24.02158  25.11859  1.000 15.92513 ? 134 TRP E CH2 1 
ATOM   1923 N  N   . SER B 1 99  ? 8.61372   16.99127  26.19116  1.000 20.55746 ? 135 SER E N   1 
ATOM   1924 C  CA  A SER B 1 99  ? 9.48971   15.92817  26.66475  0.690 22.69763 ? 135 SER E CA  1 
ATOM   1925 C  CA  B SER B 1 99  ? 9.52525   15.95748  26.65294  0.310 22.73958 ? 135 SER E CA  1 
ATOM   1926 C  C   . SER B 1 99  ? 9.78639   16.16453  28.14064  1.000 25.21200 ? 135 SER E C   1 
ATOM   1927 O  O   . SER B 1 99  ? 9.50573   17.23133  28.69742  1.000 23.84827 ? 135 SER E O   1 
ATOM   1928 C  CB  A SER B 1 99  ? 10.77959  15.81688  25.83530  0.690 25.98237 ? 135 SER E CB  1 
ATOM   1929 C  CB  B SER B 1 99  ? 10.82790  15.98838  25.85395  0.310 25.97790 ? 135 SER E CB  1 
ATOM   1930 O  OG  A SER B 1 99  ? 11.56981  16.99861  25.77213  0.690 24.67050 ? 135 SER E OG  1 
ATOM   1931 O  OG  B SER B 1 99  ? 11.74597  15.01116  26.31088  0.310 29.55495 ? 135 SER E OG  1 
ATOM   1932 N  N   . LEU B 1 100 ? 10.29524  15.13138  28.79495  1.000 25.05037 ? 136 LEU E N   1 
ATOM   1933 C  CA  . LEU B 1 100 ? 10.43667  15.21680  30.23801  1.000 26.56994 ? 136 LEU E CA  1 
ATOM   1934 C  C   . LEU B 1 100 ? 11.32308  16.39515  30.62854  1.000 26.74114 ? 136 LEU E C   1 
ATOM   1935 O  O   . LEU B 1 100 ? 12.41342  16.56074  30.08448  1.000 25.40121 ? 136 LEU E O   1 
ATOM   1936 C  CB  . LEU B 1 100 ? 11.01067  13.90363  30.78350  1.000 30.36858 ? 136 LEU E CB  1 
ATOM   1937 C  CG  . LEU B 1 100 ? 10.92897  13.82346  32.31304  1.000 38.35028 ? 136 LEU E CG  1 
ATOM   1938 C  CD1 . LEU B 1 100 ? 9.65130   13.15792  32.74138  1.000 40.24340 ? 136 LEU E CD1 1 
ATOM   1939 C  CD2 . LEU B 1 100 ? 12.13616  13.04130  32.84580  1.000 38.82405 ? 136 LEU E CD2 1 
ATOM   1940 N  N   . GLY B 1 101 ? 10.82525  17.23738  31.55541  1.000 21.75172 ? 137 GLY E N   1 
ATOM   1941 C  CA  . GLY B 1 101 ? 11.59347  18.37427  32.04947  1.000 20.96160 ? 137 GLY E CA  1 
ATOM   1942 C  C   . GLY B 1 101 ? 11.37596  19.65972  31.25888  1.000 22.62493 ? 137 GLY E C   1 
ATOM   1943 O  O   . GLY B 1 101 ? 11.87231  20.72491  31.67094  1.000 21.27558 ? 137 GLY E O   1 
ATOM   1944 N  N   . GLU B 1 102 ? 10.64200  19.59278  30.13454  1.000 19.69798 ? 138 GLU E N   1 
ATOM   1945 C  CA  . GLU B 1 102 ? 10.35753  20.77493  29.32222  1.000 17.57601 ? 138 GLU E CA  1 
ATOM   1946 C  C   . GLU B 1 102 ? 8.94903   21.30182  29.57355  1.000 16.57466 ? 138 GLU E C   1 
ATOM   1947 O  O   . GLU B 1 102 ? 8.07122   20.57666  30.05318  1.000 20.98559 ? 138 GLU E O   1 
ATOM   1948 C  CB  . GLU B 1 102 ? 10.51159  20.42479  27.83400  1.000 17.41727 ? 138 GLU E CB  1 
ATOM   1949 C  CG  . GLU B 1 102 ? 11.88599  19.74740  27.53425  1.000 18.68595 ? 138 GLU E CG  1 
ATOM   1950 C  CD  . GLU B 1 102 ? 13.10985  20.66746  27.78553  1.000 20.28225 ? 138 GLU E CD  1 
ATOM   1951 O  OE1 . GLU B 1 102 ? 12.95904  21.89187  27.90219  1.000 18.71889 ? 138 GLU E OE1 1 
ATOM   1952 O  OE2 . GLU B 1 102 ? 14.27518  20.16097  27.83423  1.000 18.54932 ? 138 GLU E OE2 1 
ATOM   1953 N  N   . PRO B 1 103 ? 8.70075   22.59138  29.27614  1.000 17.26904 ? 139 PRO E N   1 
ATOM   1954 C  CA  . PRO B 1 103 ? 9.67249   23.60755  28.79028  1.000 15.84499 ? 139 PRO E CA  1 
ATOM   1955 C  C   . PRO B 1 103 ? 10.49507  24.14058  29.97719  1.000 16.25824 ? 139 PRO E C   1 
ATOM   1956 O  O   . PRO B 1 103 ? 10.00469  24.04553  31.13703  1.000 19.30890 ? 139 PRO E O   1 
ATOM   1957 C  CB  . PRO B 1 103 ? 8.76600   24.65664  28.15191  1.000 14.63599 ? 139 PRO E CB  1 
ATOM   1958 C  CG  . PRO B 1 103 ? 7.48997   24.61134  29.01472  1.000 14.70927 ? 139 PRO E CG  1 
ATOM   1959 C  CD  . PRO B 1 103 ? 7.36452   23.17309  29.51476  1.000 17.48780 ? 139 PRO E CD  1 
ATOM   1960 N  N   . ASN B 1 104 ? 11.69029  24.66294  29.74225  1.000 14.16318 ? 140 ASN E N   1 
ATOM   1961 C  CA  . ASN B 1 104 ? 12.57342  24.93212  30.87817  1.000 17.21432 ? 140 ASN E CA  1 
ATOM   1962 C  C   . ASN B 1 104 ? 13.44900  26.18400  30.80669  1.000 14.75703 ? 140 ASN E C   1 
ATOM   1963 O  O   . ASN B 1 104 ? 14.20090  26.41345  31.77831  1.000 16.79322 ? 140 ASN E O   1 
ATOM   1964 C  CB  . ASN B 1 104 ? 13.47701  23.70449  31.13736  1.000 16.58923 ? 140 ASN E CB  1 
ATOM   1965 C  CG  . ASN B 1 104 ? 14.53230  23.48498  30.01939  1.000 19.16671 ? 140 ASN E CG  1 
ATOM   1966 O  OD1 . ASN B 1 104 ? 14.46385  24.13861  28.99807  1.000 17.84633 ? 140 ASN E OD1 1 
ATOM   1967 N  ND2 . ASN B 1 104 ? 15.47475  22.53401  30.21918  1.000 19.21549 ? 140 ASN E ND2 1 
ATOM   1968 N  N   . ASN B 1 105 ? 13.43528  26.97749  29.70601  1.000 15.35963 ? 141 ASN E N   1 
ATOM   1969 C  CA  . ASN B 1 105 ? 14.35350  28.12961  29.55288  1.000 15.58923 ? 141 ASN E CA  1 
ATOM   1970 C  C   . ASN B 1 105 ? 15.75649  27.73740  30.00469  1.000 18.67631 ? 141 ASN E C   1 
ATOM   1971 O  O   . ASN B 1 105 ? 16.37178  28.39177  30.85914  1.000 18.64750 ? 141 ASN E O   1 
ATOM   1972 C  CB  . ASN B 1 105 ? 13.88916  29.34568  30.34933  1.000 16.00020 ? 141 ASN E CB  1 
ATOM   1973 C  CG  . ASN B 1 105 ? 12.83229  30.11623  29.60993  1.000 16.68635 ? 141 ASN E CG  1 
ATOM   1974 O  OD1 . ASN B 1 105 ? 12.87988  30.22650  28.38118  1.000 17.01819 ? 141 ASN E OD1 1 
ATOM   1975 N  ND2 . ASN B 1 105 ? 11.89042  30.68028  30.35926  1.000 14.58771 ? 141 ASN E ND2 1 
ATOM   1976 N  N   . TYR B 1 106 ? 16.23608  26.63294  29.41667  1.000 19.61846 ? 142 TYR E N   1 
ATOM   1977 C  CA  . TYR B 1 106 ? 17.52139  26.00985  29.73529  1.000 19.33934 ? 142 TYR E CA  1 
ATOM   1978 C  C   . TYR B 1 106 ? 18.63708  27.01852  29.93077  1.000 23.39134 ? 142 TYR E C   1 
ATOM   1979 O  O   . TYR B 1 106 ? 18.86125  27.85900  29.07433  1.000 19.90049 ? 142 TYR E O   1 
ATOM   1980 C  CB  . TYR B 1 106 ? 17.93225  25.13713  28.58495  1.000 21.34539 ? 142 TYR E CB  1 
ATOM   1981 C  CG  . TYR B 1 106 ? 19.17877  24.29077  28.80093  1.000 21.37697 ? 142 TYR E CG  1 
ATOM   1982 C  CD1 . TYR B 1 106 ? 19.15232  23.19616  29.67963  1.000 25.97358 ? 142 TYR E CD1 1 
ATOM   1983 C  CD2 . TYR B 1 106 ? 20.29962  24.45264  27.98352  1.000 24.64210 ? 142 TYR E CD2 1 
ATOM   1984 C  CE1 . TYR B 1 106 ? 20.28158  22.33869  29.81559  1.000 26.33095 ? 142 TYR E CE1 1 
ATOM   1985 C  CE2 . TYR B 1 106 ? 21.40974  23.58908  28.11406  1.000 29.76379 ? 142 TYR E CE2 1 
ATOM   1986 C  CZ  . TYR B 1 106 ? 21.37836  22.55345  29.03067  1.000 27.63033 ? 142 TYR E CZ  1 
ATOM   1987 O  OH  . TYR B 1 106 ? 22.48109  21.72273  29.14863  1.000 37.18113 ? 142 TYR E OH  1 
ATOM   1988 N  N   . GLU B 1 107 ? 19.38823  26.85668  31.02185  1.000 23.82892 ? 143 GLU E N   1 
ATOM   1989 C  CA  . GLU B 1 107 ? 20.51053  27.75312  31.35783  1.000 24.56840 ? 143 GLU E CA  1 
ATOM   1990 C  C   . GLU B 1 107 ? 20.09381  29.22921  31.36133  1.000 20.95217 ? 143 GLU E C   1 
ATOM   1991 O  O   . GLU B 1 107 ? 20.89103  30.12500  31.11853  1.000 21.26798 ? 143 GLU E O   1 
ATOM   1992 C  CB  . GLU B 1 107 ? 21.70986  27.49514  30.42230  1.000 27.32439 ? 143 GLU E CB  1 
ATOM   1993 C  CG  . GLU B 1 107 ? 22.42507  26.20880  30.87015  1.000 34.22218 ? 143 GLU E CG  1 
ATOM   1994 C  CD  . GLU B 1 107 ? 23.59230  25.80979  29.99173  1.000 37.67111 ? 143 GLU E CD  1 
ATOM   1995 O  OE1 . GLU B 1 107 ? 23.86732  26.56432  29.03232  1.000 49.19796 ? 143 GLU E OE1 1 
ATOM   1996 O  OE2 . GLU B 1 107 ? 24.23913  24.78595  30.27544  1.000 53.52866 ? 143 GLU E OE2 1 
ATOM   1997 N  N   . GLY B 1 108 ? 18.82810  29.53041  31.63817  1.000 20.08091 ? 144 GLY E N   1 
ATOM   1998 C  CA  . GLY B 1 108 ? 18.47264  30.94996  31.63510  1.000 19.86684 ? 144 GLY E CA  1 
ATOM   1999 C  C   . GLY B 1 108 ? 18.35480  31.61242  30.26662  1.000 21.45876 ? 144 GLY E C   1 
ATOM   2000 O  O   . GLY B 1 108 ? 18.14690  32.83069  30.21244  1.000 21.36933 ? 144 GLY E O   1 
ATOM   2001 N  N   . ARG B 1 109 ? 18.45756  30.84147  29.16712  1.000 21.85364 ? 145 ARG E N   1 
ATOM   2002 C  CA  . ARG B 1 109 ? 18.24557  31.37890  27.80189  1.000 24.04793 ? 145 ARG E CA  1 
ATOM   2003 C  C   . ARG B 1 109 ? 16.76328  31.55075  27.52611  1.000 20.19503 ? 145 ARG E C   1 
ATOM   2004 O  O   . ARG B 1 109 ? 15.95530  30.80414  28.06054  1.000 20.23026 ? 145 ARG E O   1 
ATOM   2005 C  CB  . ARG B 1 109 ? 18.75159  30.39602  26.74271  1.000 24.95211 ? 145 ARG E CB  1 
ATOM   2006 C  CG  . ARG B 1 109 ? 19.96358  29.57583  27.10914  1.000 35.19564 ? 145 ARG E CG  1 
ATOM   2007 C  CD  . ARG B 1 109 ? 20.50016  28.84619  25.88592  1.000 41.40602 ? 145 ARG E CD  1 
ATOM   2008 N  NE  . ARG B 1 109 ? 21.95195  28.70658  25.94914  1.000 53.14690 ? 145 ARG E NE  1 
ATOM   2009 C  CZ  . ARG B 1 109 ? 22.60031  27.57114  25.73513  1.000 57.87547 ? 145 ARG E CZ  1 
ATOM   2010 N  NH1 . ARG B 1 109 ? 21.95230  26.46663  25.38128  1.000 51.47539 ? 145 ARG E NH1 1 
ATOM   2011 N  NH2 . ARG B 1 109 ? 23.93255  27.55088  25.84558  1.000 58.71569 ? 145 ARG E NH2 1 
ATOM   2012 N  N   . GLN B 1 110 ? 16.40444  32.54328  26.68657  1.000 22.38318 ? 146 GLN E N   1 
ATOM   2013 C  CA  . GLN B 1 110 ? 15.00860  32.74767  26.26508  1.000 20.94844 ? 146 GLN E CA  1 
ATOM   2014 C  C   . GLN B 1 110 ? 14.65367  31.68071  25.25566  1.000 17.73224 ? 146 GLN E C   1 
ATOM   2015 O  O   . GLN B 1 110 ? 15.03921  31.79487  24.09141  1.000 18.88973 ? 146 GLN E O   1 
ATOM   2016 C  CB  . GLN B 1 110 ? 14.77982  34.09474  25.60506  1.000 20.66497 ? 146 GLN E CB  1 
ATOM   2017 C  CG  . GLN B 1 110 ? 15.48838  35.24406  26.30450  1.000 33.50390 ? 146 GLN E CG  1 
ATOM   2018 C  CD  . GLN B 1 110 ? 14.73418  36.56191  26.14376  1.000 46.29944 ? 146 GLN E CD  1 
ATOM   2019 O  OE1 . GLN B 1 110 ? 13.64167  36.60082  25.54396  1.000 45.21926 ? 146 GLN E OE1 1 
ATOM   2020 N  NE2 . GLN B 1 110 ? 15.28747  37.64345  26.72207  1.000 46.72583 ? 146 GLN E NE2 1 
ATOM   2021 N  N   . GLU B 1 111 ? 14.00135  30.63137  25.69659  1.000 16.11459 ? 147 GLU E N   1 
ATOM   2022 C  CA  . GLU B 1 111 ? 13.62000  29.55127  24.79071  1.000 15.56371 ? 147 GLU E CA  1 
ATOM   2023 C  C   . GLU B 1 111 ? 12.12385  29.72450  24.45888  1.000 15.96782 ? 147 GLU E C   1 
ATOM   2024 O  O   . GLU B 1 111 ? 11.25232  29.14633  25.09778  1.000 15.10437 ? 147 GLU E O   1 
ATOM   2025 C  CB  . GLU B 1 111 ? 13.94513  28.19123  25.41861  1.000 15.42247 ? 147 GLU E CB  1 
ATOM   2026 C  CG  . GLU B 1 111 ? 15.40667  28.05428  25.71149  1.000 17.13111 ? 147 GLU E CG  1 
ATOM   2027 C  CD  . GLU B 1 111 ? 15.78805  26.60607  25.89063  1.000 17.41324 ? 147 GLU E CD  1 
ATOM   2028 O  OE1 . GLU B 1 111 ? 15.10775  25.92837  26.64907  1.000 18.22959 ? 147 GLU E OE1 1 
ATOM   2029 O  OE2 . GLU B 1 111 ? 16.72770  26.12952  25.23094  1.000 15.92575 ? 147 GLU E OE2 1 
ATOM   2030 N  N   . GLN B 1 112 ? 11.83218  30.52520  23.43908  1.000 14.86268 ? 148 GLN E N   1 
ATOM   2031 C  CA  . GLN B 1 112 ? 10.44546  30.90565  23.15880  1.000 14.93492 ? 148 GLN E CA  1 
ATOM   2032 C  C   . GLN B 1 112 ? 9.79643   30.11467  22.03884  1.000 13.87964 ? 148 GLN E C   1 
ATOM   2033 O  O   . GLN B 1 112 ? 8.60995   30.31978  21.75852  1.000 14.27419 ? 148 GLN E O   1 
ATOM   2034 C  CB  . GLN B 1 112 ? 10.43316  32.40140  22.77741  1.000 16.46456 ? 148 GLN E CB  1 
ATOM   2035 C  CG  . GLN B 1 112 ? 10.81459  33.32671  23.95181  1.000 18.08330 ? 148 GLN E CG  1 
ATOM   2036 C  CD  . GLN B 1 112 ? 11.11277  34.73102  23.49682  1.000 23.36007 ? 148 GLN E CD  1 
ATOM   2037 O  OE1 . GLN B 1 112 ? 11.64179  34.96132  22.39262  1.000 26.29463 ? 148 GLN E OE1 1 
ATOM   2038 N  NE2 . GLN B 1 112 ? 10.70872  35.68152  24.30374  1.000 22.77875 ? 148 GLN E NE2 1 
ATOM   2039 N  N   . CYS B 1 113 ? 10.55042  29.30805  21.31493  1.000 15.10468 ? 149 CYS E N   1 
ATOM   2040 C  CA  . CYS B 1 113 ? 10.02159  28.57825  20.15850  1.000 13.06711 ? 149 CYS E CA  1 
ATOM   2041 C  C   . CYS B 1 113 ? 10.07634  27.07270  20.41950  1.000 13.93640 ? 149 CYS E C   1 
ATOM   2042 O  O   . CYS B 1 113 ? 10.91073  26.60708  21.16644  1.000 18.24579 ? 149 CYS E O   1 
ATOM   2043 C  CB  . CYS B 1 113 ? 10.82312  28.89228  18.90149  1.000 11.60281 ? 149 CYS E CB  1 
ATOM   2044 S  SG  . CYS B 1 113 ? 10.45866  30.56716  18.29313  1.000 13.90260 ? 149 CYS E SG  1 
ATOM   2045 N  N   . VAL B 1 114 ? 9.19587   26.29628  19.76044  1.000 13.13998 ? 150 VAL E N   1 
ATOM   2046 C  CA  . VAL B 1 114 ? 9.07486   24.87402  20.13286  1.000 12.58247 ? 150 VAL E CA  1 
ATOM   2047 C  C   . VAL B 1 114 ? 9.57851   23.96968  19.00871  1.000 13.19133 ? 150 VAL E C   1 
ATOM   2048 O  O   . VAL B 1 114 ? 9.17162   24.11217  17.83916  1.000 13.28102 ? 150 VAL E O   1 
ATOM   2049 C  CB  . VAL B 1 114 ? 7.63328   24.48681  20.50567  1.000 12.34851 ? 150 VAL E CB  1 
ATOM   2050 C  CG1 . VAL B 1 114 ? 7.63503   22.99886  20.91932  1.000 14.65745 ? 150 VAL E CG1 1 
ATOM   2051 C  CG2 . VAL B 1 114 ? 7.17676   25.33966  21.70009  1.000 13.37082 ? 150 VAL E CG2 1 
ATOM   2052 N  N   . GLU B 1 115 ? 10.41911  23.00277  19.38050  1.000 13.02415 ? 151 GLU E N   1 
ATOM   2053 C  CA  . GLU B 1 115 ? 10.80240  21.94047  18.43161  1.000 11.97443 ? 151 GLU E CA  1 
ATOM   2054 C  C   . GLU B 1 115 ? 10.32309  20.59578  18.95404  1.000 13.43565 ? 151 GLU E C   1 
ATOM   2055 O  O   . GLU B 1 115 ? 10.16815  20.39885  20.16847  1.000 17.29099 ? 151 GLU E O   1 
ATOM   2056 C  CB  . GLU B 1 115 ? 12.35762  21.90451  18.28662  1.000 12.23787 ? 151 GLU E CB  1 
ATOM   2057 C  CG  . GLU B 1 115 ? 12.98317  21.51789  19.62108  1.000 14.75557 ? 151 GLU E CG  1 
ATOM   2058 C  CD  . GLU B 1 115 ? 14.51836  21.38928  19.56809  1.000 17.61120 ? 151 GLU E CD  1 
ATOM   2059 O  OE1 . GLU B 1 115 ? 15.16670  21.59211  18.48230  1.000 17.34269 ? 151 GLU E OE1 1 
ATOM   2060 O  OE2 . GLU B 1 115 ? 15.07354  21.06666  20.65192  1.000 17.54176 ? 151 GLU E OE2 1 
ATOM   2061 N  N   . GLN B 1 116 ? 10.08961  19.68280  18.03393  1.000 12.70928 ? 152 GLN E N   1 
ATOM   2062 C  CA  . GLN B 1 116 ? 9.99596   18.24950  18.33149  1.000 15.02243 ? 152 GLN E CA  1 
ATOM   2063 C  C   . GLN B 1 116 ? 11.40142  17.66664  18.34754  1.000 19.37384 ? 152 GLN E C   1 
ATOM   2064 O  O   . GLN B 1 116 ? 12.12675  17.78342  17.35302  1.000 17.53850 ? 152 GLN E O   1 
ATOM   2065 C  CB  . GLN B 1 116 ? 9.16341   17.56169  17.24224  1.000 14.86911 ? 152 GLN E CB  1 
ATOM   2066 C  CG  . GLN B 1 116 ? 9.22718   16.00502  17.32449  1.000 17.15160 ? 152 GLN E CG  1 
ATOM   2067 C  CD  . GLN B 1 116 ? 8.52395   15.42573  18.53595  1.000 20.36409 ? 152 GLN E CD  1 
ATOM   2068 O  OE1 . GLN B 1 116 ? 7.67280   16.08428  19.17460  1.000 20.25013 ? 152 GLN E OE1 1 
ATOM   2069 N  NE2 . GLN B 1 116 ? 8.85073   14.17059  18.85567  1.000 19.86238 ? 152 GLN E NE2 1 
ATOM   2070 N  N   . ILE B 1 117 ? 11.82446  17.07152  19.45584  1.000 18.83355 ? 153 ILE E N   1 
ATOM   2071 C  CA  . ILE B 1 117 ? 13.20796  16.58497  19.51035  1.000 22.91695 ? 153 ILE E CA  1 
ATOM   2072 C  C   . ILE B 1 117 ? 13.26695  15.11946  19.20855  1.000 29.44884 ? 153 ILE E C   1 
ATOM   2073 O  O   . ILE B 1 117 ? 12.34982  14.35654  19.50637  1.000 35.90478 ? 153 ILE E O   1 
ATOM   2074 C  CB  . ILE B 1 117 ? 13.89495  16.85359  20.85607  1.000 32.43013 ? 153 ILE E CB  1 
ATOM   2075 C  CG1 . ILE B 1 117 ? 13.22234  16.02806  21.96326  1.000 35.04840 ? 153 ILE E CG1 1 
ATOM   2076 C  CG2 . ILE B 1 117 ? 14.11085  18.33777  21.05906  1.000 26.18653 ? 153 ILE E CG2 1 
ATOM   2077 C  CD1 . ILE B 1 117 ? 13.90695  16.13793  23.32801  1.000 37.01304 ? 153 ILE E CD1 1 
ATOM   2078 N  N   . ASP B 1 118 ? 14.41064  14.71113  18.68909  1.000 30.12148 ? 154 ASP E N   1 
ATOM   2079 C  CA  . ASP B 1 118 ? 14.68559  13.32250  18.34905  1.000 38.40792 ? 154 ASP E CA  1 
ATOM   2080 C  C   . ASP B 1 118 ? 15.95623  12.93267  19.11115  1.000 41.23520 ? 154 ASP E C   1 
ATOM   2081 O  O   . ASP B 1 118 ? 17.06490  13.11576  18.60426  1.000 43.24841 ? 154 ASP E O   1 
ATOM   2082 C  CB  . ASP B 1 118 ? 14.84617  13.19345  16.82751  1.000 36.08387 ? 154 ASP E CB  1 
ATOM   2083 C  CG  . ASP B 1 118 ? 15.48187  11.87501  16.41627  1.000 44.07131 ? 154 ASP E CG  1 
ATOM   2084 O  OD1 . ASP B 1 118 ? 14.89247  10.83830  16.80265  1.000 38.03136 ? 154 ASP E OD1 1 
ATOM   2085 O  OD2 . ASP B 1 118 ? 16.54727  11.89843  15.71674  1.000 41.01737 ? 154 ASP E OD2 1 
ATOM   2086 N  N   . ARG B 1 119 ? 15.80371  12.45427  20.34828  1.000 41.02938 ? 155 ARG E N   1 
ATOM   2087 C  CA  . ARG B 1 119 ? 16.96269  12.14044  21.18065  1.000 50.31555 ? 155 ARG E CA  1 
ATOM   2088 C  C   . ARG B 1 119 ? 16.72099  10.83258  21.91921  1.000 57.58389 ? 155 ARG E C   1 
ATOM   2089 O  O   . ARG B 1 119 ? 15.59899  10.31345  21.98515  1.000 52.45515 ? 155 ARG E O   1 
ATOM   2090 C  CB  . ARG B 1 119 ? 17.30008  13.26425  22.18701  1.000 53.30076 ? 155 ARG E CB  1 
ATOM   2091 C  CG  . ARG B 1 119 ? 17.99610  14.49073  21.57033  1.000 56.54103 ? 155 ARG E CG  1 
ATOM   2092 C  CD  . ARG B 1 119 ? 18.62065  15.47336  22.60807  1.000 61.44210 ? 155 ARG E CD  1 
ATOM   2093 N  NE  . ARG B 1 119 ? 19.40797  14.80752  23.64817  1.000 72.42245 ? 155 ARG E NE  1 
ATOM   2094 C  CZ  . ARG B 1 119 ? 20.73538  14.88990  23.75701  1.000 78.00791 ? 155 ARG E CZ  1 
ATOM   2095 N  NH1 . ARG B 1 119 ? 21.46210  15.58877  22.88998  1.000 72.83195 ? 155 ARG E NH1 1 
ATOM   2096 N  NH2 . ARG B 1 119 ? 21.35344  14.24187  24.74941  1.000 67.80681 ? 155 ARG E NH2 1 
ATOM   2097 N  N   . GLU B 1 120 ? 17.80243  10.28995  22.47342  1.000 65.34318 ? 156 GLU E N   1 
ATOM   2098 C  CA  . GLU B 1 120 ? 17.70907  9.02480   23.18026  1.000 67.39994 ? 156 GLU E CA  1 
ATOM   2099 C  C   . GLU B 1 120 ? 17.17826  9.24561   24.59081  1.000 71.08113 ? 156 GLU E C   1 
ATOM   2100 O  O   . GLU B 1 120 ? 17.68814  10.09522  25.33722  1.000 69.53213 ? 156 GLU E O   1 
ATOM   2101 C  CB  . GLU B 1 120 ? 19.06400  8.32585   23.21346  1.000 73.28707 ? 156 GLU E CB  1 
ATOM   2102 C  CG  . GLU B 1 120 ? 19.39066  7.62649   21.90472  1.000 71.09617 ? 156 GLU E CG  1 
ATOM   2103 C  CD  . GLU B 1 120 ? 18.53430  6.39121   21.71216  1.000 71.50139 ? 156 GLU E CD  1 
ATOM   2104 O  OE1 . GLU B 1 120 ? 17.93611  5.94141   22.72002  1.000 72.10221 ? 156 GLU E OE1 1 
ATOM   2105 O  OE2 . GLU B 1 120 ? 18.46363  5.87181   20.56855  1.000 64.04276 ? 156 GLU E OE2 1 
ATOM   2106 N  N   . ASP B 1 121 ? 16.14303  8.47597   24.94080  1.000 71.64305 ? 157 ASP E N   1 
ATOM   2107 C  CA  . ASP B 1 121 ? 15.45256  8.54762   26.22903  1.000 75.00139 ? 157 ASP E CA  1 
ATOM   2108 C  C   . ASP B 1 121 ? 14.82337  9.91604   26.49041  1.000 73.33376 ? 157 ASP E C   1 
ATOM   2109 O  O   . ASP B 1 121 ? 14.53199  10.25451  27.64385  1.000 76.66296 ? 157 ASP E O   1 
ATOM   2110 C  CB  . ASP B 1 121 ? 16.37940  8.16233   27.39274  1.000 76.38606 ? 157 ASP E CB  1 
ATOM   2111 C  CG  . ASP B 1 121 ? 16.75788  6.68942   27.37901  1.000 79.71471 ? 157 ASP E CG  1 
ATOM   2112 O  OD1 . ASP B 1 121 ? 16.63313  6.05086   26.30726  1.000 81.52279 ? 157 ASP E OD1 1 
ATOM   2113 O  OD2 . ASP B 1 121 ? 17.15730  6.16784   28.44813  1.000 79.90251 ? 157 ASP E OD2 1 
ATOM   2114 N  N   . LYS B 1 122 ? 14.59665  10.71115  25.43834  1.000 68.11763 ? 158 LYS E N   1 
ATOM   2115 C  CA  . LYS B 1 122 ? 13.99099  12.04211  25.56754  1.000 63.86780 ? 158 LYS E CA  1 
ATOM   2116 C  C   . LYS B 1 122 ? 13.28658  12.33419  24.24257  1.000 54.05864 ? 158 LYS E C   1 
ATOM   2117 O  O   . LYS B 1 122 ? 13.93412  12.75956  23.27997  1.000 53.00139 ? 158 LYS E O   1 
ATOM   2118 C  CB  . LYS B 1 122 ? 15.04479  13.10673  25.88635  1.000 67.29809 ? 158 LYS E CB  1 
ATOM   2119 C  CG  . LYS B 1 122 ? 15.70696  12.96003  27.26965  1.000 77.06629 ? 158 LYS E CG  1 
ATOM   2120 C  CD  . LYS B 1 122 ? 16.78757  13.99600  27.56705  1.000 81.24357 ? 158 LYS E CD  1 
ATOM   2121 C  CE  . LYS B 1 122 ? 17.37320  13.77270  28.97892  1.000 88.04182 ? 158 LYS E CE  1 
ATOM   2122 N  NZ  . LYS B 1 122 ? 18.46570  14.73365  29.35354  1.000 82.67598 ? 158 LYS E NZ  1 
ATOM   2123 N  N   . LYS B 1 123 ? 11.97619  12.10725  24.19075  1.000 49.61696 ? 159 LYS E N   1 
ATOM   2124 C  CA  . LYS B 1 123 ? 11.22634  12.41702  22.98130  1.000 47.53558 ? 159 LYS E CA  1 
ATOM   2125 C  C   . LYS B 1 123 ? 10.01422  13.29423  23.27912  1.000 37.32994 ? 159 LYS E C   1 
ATOM   2126 O  O   . LYS B 1 123 ? 9.37137   13.15878  24.31838  1.000 37.78834 ? 159 LYS E O   1 
ATOM   2127 C  CB  . LYS B 1 123 ? 10.78486  11.15427  22.26861  1.000 48.09283 ? 159 LYS E CB  1 
ATOM   2128 C  CG  . LYS B 1 123 ? 11.93818  10.33848  21.70733  1.000 54.11465 ? 159 LYS E CG  1 
ATOM   2129 C  CD  . LYS B 1 123 ? 12.61716  11.01636  20.49437  1.000 47.77394 ? 159 LYS E CD  1 
ATOM   2130 C  CE  . LYS B 1 123 ? 13.51609  10.00452  19.72843  1.000 53.57061 ? 159 LYS E CE  1 
ATOM   2131 N  NZ  . LYS B 1 123 ? 12.82733  8.68243   19.52002  1.000 54.50122 ? 159 LYS E NZ  1 
ATOM   2132 N  N   . GLY B 1 124 ? 9.69021   14.17567  22.34052  1.000 30.76817 ? 160 GLY E N   1 
ATOM   2133 C  CA  . GLY B 1 124 ? 8.58860   15.08571  22.55751  1.000 23.03441 ? 160 GLY E CA  1 
ATOM   2134 C  C   . GLY B 1 124 ? 9.06170   16.47862  22.28362  1.000 20.91924 ? 160 GLY E C   1 
ATOM   2135 O  O   . GLY B 1 124 ? 10.12767  16.68222  21.68527  1.000 20.54127 ? 160 GLY E O   1 
ATOM   2136 N  N   . TRP B 1 125 ? 8.30218   17.45110  22.78746  1.000 18.76835 ? 161 TRP E N   1 
ATOM   2137 C  CA  . TRP B 1 125 ? 8.59820   18.84367  22.48726  1.000 15.22447 ? 161 TRP E CA  1 
ATOM   2138 C  C   . TRP B 1 125 ? 9.62561   19.41759  23.43717  1.000 17.19232 ? 161 TRP E C   1 
ATOM   2139 O  O   . TRP B 1 125 ? 9.75442   19.01545  24.60241  1.000 19.12404 ? 161 TRP E O   1 
ATOM   2140 C  CB  . TRP B 1 125 ? 7.38398   19.74888  22.62144  1.000 13.52080 ? 161 TRP E CB  1 
ATOM   2141 C  CG  . TRP B 1 125 ? 6.14200   19.31621  21.84154  1.000 14.44832 ? 161 TRP E CG  1 
ATOM   2142 C  CD1 . TRP B 1 125 ? 6.06968   18.40435  20.82444  1.000 15.46493 ? 161 TRP E CD1 1 
ATOM   2143 C  CD2 . TRP B 1 125 ? 4.80118   19.77353  22.08698  1.000 14.04655 ? 161 TRP E CD2 1 
ATOM   2144 N  NE1 . TRP B 1 125 ? 4.74130   18.30127  20.36127  1.000 13.13504 ? 161 TRP E NE1 1 
ATOM   2145 C  CE2 . TRP B 1 125 ? 3.95181   19.13979  21.12682  1.000 16.53767 ? 161 TRP E CE2 1 
ATOM   2146 C  CE3 . TRP B 1 125 ? 4.24102   20.71631  22.98042  1.000 14.57172 ? 161 TRP E CE3 1 
ATOM   2147 C  CZ2 . TRP B 1 125 ? 2.56368   19.38938  21.07269  1.000 16.28675 ? 161 TRP E CZ2 1 
ATOM   2148 C  CZ3 . TRP B 1 125 ? 2.85873   20.95115  22.92551  1.000 15.65511 ? 161 TRP E CZ3 1 
ATOM   2149 C  CH2 . TRP B 1 125 ? 2.04520   20.29127  21.97826  1.000 17.39809 ? 161 TRP E CH2 1 
ATOM   2150 N  N   . ASN B 1 126 ? 10.27696  20.47505  22.95119  1.000 14.53278 ? 162 ASN E N   1 
ATOM   2151 C  CA  . ASN B 1 126 ? 11.29973  21.14006  23.73118  1.000 14.50412 ? 162 ASN E CA  1 
ATOM   2152 C  C   . ASN B 1 126 ? 11.23955  22.61088  23.37149  1.000 14.02714 ? 162 ASN E C   1 
ATOM   2153 O  O   . ASN B 1 126 ? 11.15788  22.92065  22.17676  1.000 13.67317 ? 162 ASN E O   1 
ATOM   2154 C  CB  . ASN B 1 126 ? 12.68961  20.59439  23.42987  1.000 15.06741 ? 162 ASN E CB  1 
ATOM   2155 C  CG  . ASN B 1 126 ? 13.76505  21.47244  24.03127  1.000 15.69298 ? 162 ASN E CG  1 
ATOM   2156 O  OD1 . ASN B 1 126 ? 13.68456  21.82077  25.22372  1.000 14.64081 ? 162 ASN E OD1 1 
ATOM   2157 N  ND2 . ASN B 1 126 ? 14.78693  21.79813  23.25658  1.000 15.14745 ? 162 ASN E ND2 1 
ATOM   2158 N  N   . ASP B 1 127 ? 11.22746  23.51203  24.37235  1.000 13.56010 ? 163 ASP E N   1 
ATOM   2159 C  CA  . ASP B 1 127 ? 11.43038  24.92566  24.03809  1.000 13.02592 ? 163 ASP E CA  1 
ATOM   2160 C  C   . ASP B 1 127 ? 12.91560  25.21948  23.77800  1.000 14.50317 ? 163 ASP E C   1 
ATOM   2161 O  O   . ASP B 1 127 ? 13.80534  24.65893  24.43769  1.000 15.49531 ? 163 ASP E O   1 
ATOM   2162 C  CB  . ASP B 1 127 ? 10.88976  25.88234  25.14151  1.000 12.51799 ? 163 ASP E CB  1 
ATOM   2163 C  CG  . ASP B 1 127 ? 11.56185  25.65015  26.54653  1.000 13.34962 ? 163 ASP E CG  1 
ATOM   2164 O  OD1 . ASP B 1 127 ? 12.04552  24.50942  26.88958  1.000 15.07287 ? 163 ASP E OD1 1 
ATOM   2165 O  OD2 . ASP B 1 127 ? 11.53175  26.59279  27.32284  1.000 12.49379 ? 163 ASP E OD2 1 
ATOM   2166 N  N   . LEU B 1 128 ? 13.17500  26.07971  22.78746  1.000 13.16919 ? 164 LEU E N   1 
ATOM   2167 C  CA  . LEU B 1 128 ? 14.51845  26.32873  22.27346  1.000 12.76226 ? 164 LEU E CA  1 
ATOM   2168 C  C   . LEU B 1 128 ? 14.62962  27.78194  21.83562  1.000 16.49223 ? 164 LEU E C   1 
ATOM   2169 O  O   . LEU B 1 128 ? 13.64759  28.37991  21.44491  1.000 16.32781 ? 164 LEU E O   1 
ATOM   2170 C  CB  . LEU B 1 128 ? 14.82716  25.39872  21.08374  1.000 14.48903 ? 164 LEU E CB  1 
ATOM   2171 C  CG  . LEU B 1 128 ? 16.27142  25.39667  20.62602  1.000 14.58965 ? 164 LEU E CG  1 
ATOM   2172 C  CD1 . LEU B 1 128 ? 17.05970  24.77509  21.79077  1.000 15.95816 ? 164 LEU E CD1 1 
ATOM   2173 C  CD2 . LEU B 1 128 ? 16.42938  24.55402  19.32917  1.000 14.34142 ? 164 LEU E CD2 1 
ATOM   2174 N  N   . VAL B 1 129 ? 15.83819  28.36505  21.89329  1.000 14.40702 ? 165 VAL E N   1 
ATOM   2175 C  CA  A VAL B 1 129 ? 16.07021  29.72142  21.37667  0.847 14.77929 ? 165 VAL E CA  1 
ATOM   2176 C  CA  B VAL B 1 129 ? 15.92464  29.74195  21.42781  0.153 15.07741 ? 165 VAL E CA  1 
ATOM   2177 C  C   . VAL B 1 129 ? 15.61645  29.80606  19.92529  1.000 17.22714 ? 165 VAL E C   1 
ATOM   2178 O  O   . VAL B 1 129 ? 16.03290  28.96481  19.10369  1.000 14.63908 ? 165 VAL E O   1 
ATOM   2179 C  CB  A VAL B 1 129 ? 17.56090  30.03977  21.49258  0.847 16.93110 ? 165 VAL E CB  1 
ATOM   2180 C  CB  B VAL B 1 129 ? 17.28781  30.32178  21.77703  0.153 17.46700 ? 165 VAL E CB  1 
ATOM   2181 C  CG1 A VAL B 1 129 ? 17.83810  31.39192  20.83692  0.847 17.60806 ? 165 VAL E CG1 1 
ATOM   2182 C  CG1 B VAL B 1 129 ? 17.46548  30.41030  23.28641  0.153 16.73910 ? 165 VAL E CG1 1 
ATOM   2183 C  CG2 A VAL B 1 129 ? 17.94364  29.97665  22.99956  0.847 17.39492 ? 165 VAL E CG2 1 
ATOM   2184 C  CG2 B VAL B 1 129 ? 18.12857  29.41712  21.37304  0.153 15.49817 ? 165 VAL E CG2 1 
ATOM   2185 N  N   . CYS B 1 130 ? 14.76501  30.78069  19.58360  1.000 14.81794 ? 166 CYS E N   1 
ATOM   2186 C  CA  . CYS B 1 130 ? 14.14333  30.81091  18.24646  1.000 16.07536 ? 166 CYS E CA  1 
ATOM   2187 C  C   . CYS B 1 130 ? 15.17856  31.03649  17.16009  1.000 17.69448 ? 166 CYS E C   1 
ATOM   2188 O  O   . CYS B 1 130 ? 14.93978  30.66810  16.01826  1.000 17.23707 ? 166 CYS E O   1 
ATOM   2189 C  CB  . CYS B 1 130 ? 13.13434  31.95439  18.12276  1.000 16.73015 ? 166 CYS E CB  1 
ATOM   2190 S  SG  . CYS B 1 130 ? 11.78026  31.83686  19.34773  1.000 17.06451 ? 166 CYS E SG  1 
ATOM   2191 N  N   . GLU B 1 131 ? 16.28877  31.72127  17.48052  1.000 16.98828 ? 167 GLU E N   1 
ATOM   2192 C  CA  . GLU B 1 131 ? 17.34069  31.98395  16.49752  1.000 21.69080 ? 167 GLU E CA  1 
ATOM   2193 C  C   . GLU B 1 131 ? 18.21367  30.77964  16.19008  1.000 17.76817 ? 167 GLU E C   1 
ATOM   2194 O  O   . GLU B 1 131 ? 19.05664  30.90108  15.28371  1.000 18.86015 ? 167 GLU E O   1 
ATOM   2195 C  CB  . GLU B 1 131 ? 18.25328  33.15287  16.94695  1.000 21.94270 ? 167 GLU E CB  1 
ATOM   2196 C  CG  . GLU B 1 131 ? 17.45175  34.45598  16.99862  1.000 29.66765 ? 167 GLU E CG  1 
ATOM   2197 C  CD  . GLU B 1 131 ? 16.30797  34.52943  18.14528  1.000 60.78541 ? 167 GLU E CD  1 
ATOM   2198 O  OE1 . GLU B 1 131 ? 15.17597  35.01046  17.81845  1.000 50.73497 ? 167 GLU E OE1 1 
ATOM   2199 O  OE2 . GLU B 1 131 ? 16.49366  34.11037  19.34317  1.000 48.71692 ? 167 GLU E OE2 1 
ATOM   2200 N  N   . PHE B 1 132 ? 18.04099  29.64664  16.88317  1.000 17.33883 ? 168 PHE E N   1 
ATOM   2201 C  CA  . PHE B 1 132 ? 18.77731  28.43719  16.50802  1.000 17.37708 ? 168 PHE E CA  1 
ATOM   2202 C  C   . PHE B 1 132 ? 18.12264  27.85421  15.27252  1.000 15.94855 ? 168 PHE E C   1 
ATOM   2203 O  O   . PHE B 1 132 ? 17.07777  28.34333  14.85058  1.000 16.98640 ? 168 PHE E O   1 
ATOM   2204 C  CB  . PHE B 1 132 ? 18.78572  27.35996  17.59836  1.000 20.53047 ? 168 PHE E CB  1 
ATOM   2205 C  CG  . PHE B 1 132 ? 19.56263  27.73232  18.85954  1.000 22.98257 ? 168 PHE E CG  1 
ATOM   2206 C  CD1 . PHE B 1 132 ? 20.20760  28.97458  18.99372  1.000 24.26968 ? 168 PHE E CD1 1 
ATOM   2207 C  CD2 . PHE B 1 132 ? 19.63245  26.81825  19.92550  1.000 22.38162 ? 168 PHE E CD2 1 
ATOM   2208 C  CE1 . PHE B 1 132 ? 20.90578  29.26531  20.15925  1.000 25.14308 ? 168 PHE E CE1 1 
ATOM   2209 C  CE2 . PHE B 1 132 ? 20.33201  27.12635  21.10220  1.000 25.95631 ? 168 PHE E CE2 1 
ATOM   2210 C  CZ  . PHE B 1 132 ? 20.95691  28.34606  21.21069  1.000 26.01677 ? 168 PHE E CZ  1 
ATOM   2211 N  N   . SER B 1 133 ? 18.77284  26.85708  14.64511  1.000 16.44319 ? 169 SER E N   1 
ATOM   2212 C  CA  . SER B 1 133 ? 18.29278  26.35278  13.36078  1.000 14.29727 ? 169 SER E CA  1 
ATOM   2213 C  C   . SER B 1 133 ? 17.90840  24.87576  13.42738  1.000 14.78764 ? 169 SER E C   1 
ATOM   2214 O  O   . SER B 1 133 ? 18.53378  24.08204  14.11821  1.000 15.75617 ? 169 SER E O   1 
ATOM   2215 C  CB  . SER B 1 133 ? 19.34059  26.56592  12.25889  1.000 14.79823 ? 169 SER E CB  1 
ATOM   2216 O  OG  . SER B 1 133 ? 19.30745  27.95022  11.78384  1.000 18.70266 ? 169 SER E OG  1 
ATOM   2217 N  N   . ASN B 1 134 ? 16.82568  24.51268  12.75459  1.000 12.45711 ? 170 ASN E N   1 
ATOM   2218 C  CA  . ASN B 1 134 ? 16.34749  23.13184  12.69199  1.000 12.18721 ? 170 ASN E CA  1 
ATOM   2219 C  C   . ASN B 1 134 ? 15.70511  22.98212  11.32914  1.000 13.32259 ? 170 ASN E C   1 
ATOM   2220 O  O   . ASN B 1 134 ? 15.24893  23.97760  10.77212  1.000 12.31206 ? 170 ASN E O   1 
ATOM   2221 C  CB  . ASN B 1 134 ? 15.20544  22.82205  13.71804  1.000 10.34132 ? 170 ASN E CB  1 
ATOM   2222 C  CG  . ASN B 1 134 ? 15.71294  22.57959  15.10134  1.000 12.99710 ? 170 ASN E CG  1 
ATOM   2223 O  OD1 . ASN B 1 134 ? 16.70296  21.82159  15.32021  1.000 17.04816 ? 170 ASN E OD1 1 
ATOM   2224 N  ND2 . ASN B 1 134 ? 15.02111  23.17562  16.07577  1.000 13.70393 ? 170 ASN E ND2 1 
ATOM   2225 N  N   . PHE B 1 135 ? 15.62607  21.73965  10.83162  1.000 12.96547 ? 171 PHE E N   1 
ATOM   2226 C  CA  . PHE B 1 135 ? 14.58896  21.41318  9.83876   1.000 12.29915 ? 171 PHE E CA  1 
ATOM   2227 C  C   . PHE B 1 135 ? 13.22010  21.78197  10.39801  1.000 13.57663 ? 171 PHE E C   1 
ATOM   2228 O  O   . PHE B 1 135 ? 13.02936  21.91104  11.61432  1.000 14.01772 ? 171 PHE E O   1 
ATOM   2229 C  CB  . PHE B 1 135 ? 14.55042  19.91232  9.49522   1.000 11.41789 ? 171 PHE E CB  1 
ATOM   2230 C  CG  . PHE B 1 135 ? 15.87726  19.42563  8.90336   1.000 15.98890 ? 171 PHE E CG  1 
ATOM   2231 C  CD1 . PHE B 1 135 ? 16.33997  19.96335  7.69363   1.000 15.50461 ? 171 PHE E CD1 1 
ATOM   2232 C  CD2 . PHE B 1 135 ? 16.64495  18.52053  9.57191   1.000 16.88696 ? 171 PHE E CD2 1 
ATOM   2233 C  CE1 . PHE B 1 135 ? 17.60366  19.58835  7.13844   1.000 14.97262 ? 171 PHE E CE1 1 
ATOM   2234 C  CE2 . PHE B 1 135 ? 17.93151  18.10045  9.05016   1.000 18.36121 ? 171 PHE E CE2 1 
ATOM   2235 C  CZ  . PHE B 1 135 ? 18.38888  18.65948  7.82655   1.000 17.80146 ? 171 PHE E CZ  1 
ATOM   2236 N  N   . TYR B 1 136 ? 12.27509  22.00995  9.48331   1.000 11.69475 ? 172 TYR E N   1 
ATOM   2237 C  CA  . TYR B 1 136 ? 10.94373  22.44880  9.89674   1.000 12.14932 ? 172 TYR E CA  1 
ATOM   2238 C  C   . TYR B 1 136 ? 9.87522   21.73762  9.07228   1.000 12.11247 ? 172 TYR E C   1 
ATOM   2239 O  O   . TYR B 1 136 ? 10.10774  21.27065  7.96223   1.000 14.11325 ? 172 TYR E O   1 
ATOM   2240 C  CB  . TYR B 1 136 ? 10.76710  23.96545  9.74191   1.000 12.41720 ? 172 TYR E CB  1 
ATOM   2241 C  CG  . TYR B 1 136 ? 11.19309  24.50267  8.37748   1.000 13.13246 ? 172 TYR E CG  1 
ATOM   2242 C  CD1 . TYR B 1 136 ? 12.53000  24.83526  8.12584   1.000 14.95853 ? 172 TYR E CD1 1 
ATOM   2243 C  CD2 . TYR B 1 136 ? 10.23474  24.73579  7.37908   1.000 12.63999 ? 172 TYR E CD2 1 
ATOM   2244 C  CE1 . TYR B 1 136 ? 12.90951  25.38917  6.88592   1.000 15.67474 ? 172 TYR E CE1 1 
ATOM   2245 C  CE2 . TYR B 1 136 ? 10.57923  25.25965  6.15195   1.000 15.77601 ? 172 TYR E CE2 1 
ATOM   2246 C  CZ  . TYR B 1 136 ? 11.90481  25.56873  5.91073   1.000 15.44985 ? 172 TYR E CZ  1 
ATOM   2247 O  OH  . TYR B 1 136 ? 12.24801  26.09787  4.70382   1.000 19.49761 ? 172 TYR E OH  1 
ATOM   2248 N  N   . MET B 1 137 ? 8.69416   21.64900  9.66910   1.000 12.46599 ? 173 MET E N   1 
ATOM   2249 C  CA  A MET B 1 137 ? 7.55759   20.98281  9.03789   0.710 13.43940 ? 173 MET E CA  1 
ATOM   2250 C  CA  B MET B 1 137 ? 7.56643   21.00809  9.00937   0.143 14.06816 ? 173 MET E CA  1 
ATOM   2251 C  CA  C MET B 1 137 ? 7.52769   20.97811  9.09637   0.147 14.02759 ? 173 MET E CA  1 
ATOM   2252 C  C   . MET B 1 137 ? 6.43740   22.00743  8.83704   1.000 14.97977 ? 173 MET E C   1 
ATOM   2253 O  O   . MET B 1 137 ? 5.99196   22.64432  9.79584   1.000 13.01282 ? 173 MET E O   1 
ATOM   2254 C  CB  A MET B 1 137 ? 7.02784   19.79850  9.90433   0.710 14.19519 ? 173 MET E CB  1 
ATOM   2255 C  CB  B MET B 1 137 ? 7.05371   19.76728  9.75450   0.143 14.25841 ? 173 MET E CB  1 
ATOM   2256 C  CB  C MET B 1 137 ? 6.97444   19.93848  10.07673  0.147 14.18537 ? 173 MET E CB  1 
ATOM   2257 C  CG  A MET B 1 137 ? 5.69130   19.14472  9.34961   0.710 15.35341 ? 173 MET E CG  1 
ATOM   2258 C  CG  B MET B 1 137 ? 5.97845   19.02006  8.92656   0.143 14.84595 ? 173 MET E CG  1 
ATOM   2259 C  CG  C MET B 1 137 ? 5.74080   19.24361  9.54021   0.147 15.10756 ? 173 MET E CG  1 
ATOM   2260 S  SD  A MET B 1 137 ? 5.14012   17.82620  10.45464  0.710 17.00893 ? 173 MET E SD  1 
ATOM   2261 S  SD  B MET B 1 137 ? 5.72753   17.28436  9.33941   0.143 15.65653 ? 173 MET E SD  1 
ATOM   2262 S  SD  C MET B 1 137 ? 6.07706   18.08668  8.23380   0.147 16.33461 ? 173 MET E SD  1 
ATOM   2263 C  CE  A MET B 1 137 ? 6.00228   16.47310  9.59454   0.710 16.13279 ? 173 MET E CE  1 
ATOM   2264 C  CE  B MET B 1 137 ? 4.62123   17.42589  10.74857  0.143 13.69128 ? 173 MET E CE  1 
ATOM   2265 C  CE  C MET B 1 137 ? 6.56996   16.66110  9.21572   0.147 15.53562 ? 173 MET E CE  1 
ATOM   2266 N  N   . CYS B 1 138 ? 5.99135   22.14007  7.60162   1.000 11.89650 ? 174 CYS E N   1 
ATOM   2267 C  CA  . CYS B 1 138 ? 4.81616   22.97236  7.32148   1.000 13.78258 ? 174 CYS E CA  1 
ATOM   2268 C  C   . CYS B 1 138 ? 3.57130   22.09524  7.33806   1.000 16.04473 ? 174 CYS E C   1 
ATOM   2269 O  O   . CYS B 1 138 ? 3.64690   20.90884  7.01106   1.000 12.83475 ? 174 CYS E O   1 
ATOM   2270 C  CB  . CYS B 1 138 ? 4.88969   23.57426  5.95414   1.000 15.60781 ? 174 CYS E CB  1 
ATOM   2271 S  SG  . CYS B 1 138 ? 6.29674   24.62347  5.62821   1.000 16.50303 ? 174 CYS E SG  1 
ATOM   2272 N  N   . GLU B 1 139 ? 2.41397   22.69311  7.64561   1.000 15.55616 ? 175 GLU E N   1 
ATOM   2273 C  CA  . GLU B 1 139 ? 1.14427   21.96492  7.51449   1.000 14.59758 ? 175 GLU E CA  1 
ATOM   2274 C  C   . GLU B 1 139 ? 0.16747   22.87223  6.79831   1.000 17.40961 ? 175 GLU E C   1 
ATOM   2275 O  O   . GLU B 1 139 ? 0.15364   24.07700  7.05861   1.000 15.85412 ? 175 GLU E O   1 
ATOM   2276 C  CB  . GLU B 1 139 ? 0.57223   21.60563  8.87841   1.000 17.07519 ? 175 GLU E CB  1 
ATOM   2277 C  CG  . GLU B 1 139 ? -0.71813  20.73409  8.76445   1.000 17.63085 ? 175 GLU E CG  1 
ATOM   2278 C  CD  . GLU B 1 139 ? -1.42852  20.55800  10.09586  1.000 19.70823 ? 175 GLU E CD  1 
ATOM   2279 O  OE1 . GLU B 1 139 ? -0.90901  20.99342  11.18633  1.000 15.68541 ? 175 GLU E OE1 1 
ATOM   2280 O  OE2 . GLU B 1 139 ? -2.54651  19.94961  10.04938  1.000 21.27735 ? 175 GLU E OE2 1 
ATOM   2281 N  N   . LYS B 1 140 ? -0.60532  22.31161  5.86694   1.000 16.53214 ? 176 LYS E N   1 
ATOM   2282 C  CA  . LYS B 1 140 ? -1.65402  23.06211  5.16953   1.000 17.83842 ? 176 LYS E CA  1 
ATOM   2283 C  C   . LYS B 1 140 ? -2.92917  22.25156  5.21056   1.000 22.17688 ? 176 LYS E C   1 
ATOM   2284 O  O   . LYS B 1 140 ? -2.95014  21.10913  4.74401   1.000 19.49067 ? 176 LYS E O   1 
ATOM   2285 C  CB  . LYS B 1 140 ? -1.28603  23.34701  3.73737   1.000 19.91306 ? 176 LYS E CB  1 
ATOM   2286 C  CG  . LYS B 1 140 ? -2.29427  24.31299  3.18207   1.000 23.85215 ? 176 LYS E CG  1 
ATOM   2287 C  CD  . LYS B 1 140 ? -2.17942  24.47607  1.73864   1.000 23.66281 ? 176 LYS E CD  1 
ATOM   2288 C  CE  . LYS B 1 140 ? -3.42208  25.32160  1.25023   1.000 23.54639 ? 176 LYS E CE  1 
ATOM   2289 N  NZ  . LYS B 1 140 ? -3.85063  26.52440  2.06555   1.000 18.72488 ? 176 LYS E NZ  1 
ATOM   2290 N  N   . ARG B 1 141 ? -3.96096  22.80281  5.83480   1.000 23.43183 ? 177 ARG E N   1 
ATOM   2291 C  CA  . ARG B 1 141 ? -5.24275  22.13703  5.82853   1.000 24.82693 ? 177 ARG E CA  1 
ATOM   2292 C  C   . ARG B 1 141 ? -5.81112  22.19680  4.40198   1.000 22.01065 ? 177 ARG E C   1 
ATOM   2293 O  O   . ARG B 1 141 ? -5.83233  23.24088  3.72913   1.000 21.51905 ? 177 ARG E O   1 
ATOM   2294 C  CB  . ARG B 1 141 ? -6.12783  22.78865  6.88865   1.000 28.21494 ? 177 ARG E CB  1 
ATOM   2295 C  CG  . ARG B 1 141 ? -5.47533  22.58627  8.25607   1.000 32.83171 ? 177 ARG E CG  1 
ATOM   2296 C  CD  . ARG B 1 141 ? -6.38888  22.70874  9.45963   1.000 38.22936 ? 177 ARG E CD  1 
ATOM   2297 N  NE  . ARG B 1 141 ? -7.52501  21.80828  9.37562   1.000 43.15716 ? 177 ARG E NE  1 
ATOM   2298 C  CZ  . ARG B 1 141 ? -7.46169  20.52778  9.68579   1.000 51.60107 ? 177 ARG E CZ  1 
ATOM   2299 N  NH1 . ARG B 1 141 ? -6.34437  19.99413  10.16050  1.000 55.05862 ? 177 ARG E NH1 1 
ATOM   2300 N  NH2 . ARG B 1 141 ? -8.53987  19.75900  9.51209   1.000 53.94712 ? 177 ARG E NH2 1 
ATOM   2301 N  N   . ILE B 1 142 ? -6.19588  21.04336  3.89338   1.000 21.55009 ? 178 ILE E N   1 
ATOM   2302 C  CA  . ILE B 1 142 ? -6.76756  20.97941  2.56850   1.000 20.51579 ? 178 ILE E CA  1 
ATOM   2303 C  C   . ILE B 1 142 ? -8.24175  20.59856  2.63003   1.000 23.60452 ? 178 ILE E C   1 
ATOM   2304 O  O   . ILE B 1 142 ? -9.07388  21.19772  1.94156   1.000 24.39536 ? 178 ILE E O   1 
ATOM   2305 C  CB  . ILE B 1 142 ? -5.97130  20.01356  1.66617   1.000 20.50747 ? 178 ILE E CB  1 
ATOM   2306 C  CG1 . ILE B 1 142 ? -4.60233  20.60972  1.31891   1.000 24.22648 ? 178 ILE E CG1 1 
ATOM   2307 C  CG2 . ILE B 1 142 ? -6.76105  19.73691  0.37213   1.000 21.95553 ? 178 ILE E CG2 1 
ATOM   2308 C  CD1 . ILE B 1 142 ? -4.64573  21.81107  0.32817   1.000 23.77810 ? 178 ILE E CD1 1 
ATOM   2309 N  N   . PHE B 1 143 ? -8.58417  19.63407  3.45824   1.000 21.88758 ? 179 PHE E N   1 
ATOM   2310 C  CA  . PHE B 1 143 ? -9.94162  19.19657  3.48135   1.000 24.03554 ? 179 PHE E CA  1 
ATOM   2311 C  C   . PHE B 1 143 ? -10.61847 19.65449  4.76566   1.000 27.87474 ? 179 PHE E C   1 
ATOM   2312 O  O   . PHE B 1 143 ? -10.02131 19.57673  5.84646   1.000 29.81636 ? 179 PHE E O   1 
ATOM   2313 C  CB  . PHE B 1 143 ? -10.01542 17.67605  3.38888   1.000 25.85417 ? 179 PHE E CB  1 
ATOM   2314 C  CG  . PHE B 1 143 ? -9.31404  17.11069  2.18763   1.000 25.09020 ? 179 PHE E CG  1 
ATOM   2315 C  CD1 . PHE B 1 143 ? -9.91118  17.17686  0.93019   1.000 28.73609 ? 179 PHE E CD1 1 
ATOM   2316 C  CD2 . PHE B 1 143 ? -8.06537  16.51181  2.30034   1.000 25.84921 ? 179 PHE E CD2 1 
ATOM   2317 C  CE1 . PHE B 1 143 ? -9.28430  16.65888  -0.19123  1.000 28.52856 ? 179 PHE E CE1 1 
ATOM   2318 C  CE2 . PHE B 1 143 ? -7.41179  15.96305  1.13773   1.000 26.15363 ? 179 PHE E CE2 1 
ATOM   2319 C  CZ  . PHE B 1 143 ? -8.03473  16.04509  -0.09912  1.000 27.55679 ? 179 PHE E CZ  1 
ATOM   2320 N  N   . PRO B 1 144 ? -11.85894 20.11927  4.67738   1.000 31.31661 ? 180 PRO E N   1 
ATOM   2321 C  CA  . PRO B 1 144 ? -12.54391 20.69010  5.85443   1.000 33.52601 ? 180 PRO E CA  1 
ATOM   2322 C  C   . PRO B 1 144 ? -12.95163 19.60568  6.87278   1.000 37.50094 ? 180 PRO E C   1 
ATOM   2323 O  O   . PRO B 1 144 ? -13.17178 18.45214  6.46643   1.000 37.56293 ? 180 PRO E O   1 
ATOM   2324 C  CB  . PRO B 1 144 ? -13.77227 21.38803  5.22866   1.000 33.62051 ? 180 PRO E CB  1 
ATOM   2325 C  CG  . PRO B 1 144 ? -14.08470 20.55293  3.98415   1.000 31.59101 ? 180 PRO E CG  1 
ATOM   2326 C  CD  . PRO B 1 144 ? -12.72065 20.08505  3.47369   1.000 32.36241 ? 180 PRO E CD  1 
HETATM 2327 C  C1  A GLC C 2 .   ? 30.29398  2.30027   3.00202   0.765 28.25100 ? 201 GLC A C1  1 
HETATM 2328 C  C2  A GLC C 2 .   ? 30.31292  2.08197   1.41610   0.765 24.85915 ? 201 GLC A C2  1 
HETATM 2329 C  C3  A GLC C 2 .   ? 29.04060  1.26296   0.95426   0.765 22.03740 ? 201 GLC A C3  1 
HETATM 2330 C  C4  A GLC C 2 .   ? 28.93526  -0.03804  1.85410   0.765 22.22962 ? 201 GLC A C4  1 
HETATM 2331 C  C5  A GLC C 2 .   ? 28.79265  0.47148   3.31535   0.765 24.38234 ? 201 GLC A C5  1 
HETATM 2332 C  C6  A GLC C 2 .   ? 28.50485  -0.65975  4.25265   0.765 25.82875 ? 201 GLC A C6  1 
HETATM 2333 O  O1  A GLC C 2 .   ? 29.25700  3.18566   3.23283   0.765 32.18209 ? 201 GLC A O1  1 
HETATM 2334 O  O2  A GLC C 2 .   ? 30.20369  3.34121   0.79595   0.765 26.64426 ? 201 GLC A O2  1 
HETATM 2335 O  O3  A GLC C 2 .   ? 29.22861  0.86453   -0.35762  0.765 19.56113 ? 201 GLC A O3  1 
HETATM 2336 O  O4  A GLC C 2 .   ? 27.83432  -0.83724  1.38532   0.765 19.37658 ? 201 GLC A O4  1 
HETATM 2337 O  O5  A GLC C 2 .   ? 29.93751  1.13124   3.73076   0.765 27.52293 ? 201 GLC A O5  1 
HETATM 2338 O  O6  A GLC C 2 .   ? 28.87751  -0.20122  5.52982   0.765 34.12422 ? 201 GLC A O6  1 
HETATM 2339 C  C2  B BGC D 3 .   ? 28.61390  0.36956   3.34558   0.323 24.42667 ? 202 BGC A C2  1 
HETATM 2340 C  C3  B BGC D 3 .   ? 28.85813  -0.03704  1.87004   0.323 22.24749 ? 202 BGC A C3  1 
HETATM 2341 C  C4  B BGC D 3 .   ? 28.94649  1.24047   0.98049   0.323 22.04665 ? 202 BGC A C4  1 
HETATM 2342 C  C5  B BGC D 3 .   ? 30.12284  2.09229   1.58062   0.323 24.99960 ? 202 BGC A C5  1 
HETATM 2343 C  C6  B BGC D 3 .   ? 30.15333  3.45973   0.84696   0.323 26.77313 ? 202 BGC A C6  1 
HETATM 2344 C  C1  B BGC D 3 .   ? 29.80068  1.26889   3.79482   0.323 26.92882 ? 202 BGC A C1  1 
HETATM 2345 O  O1  B BGC D 3 .   ? 29.48029  1.75307   5.07761   0.323 28.08999 ? 202 BGC A O1  1 
HETATM 2346 O  O2  B BGC D 3 .   ? 28.59372  -0.78917  4.10561   0.323 25.80882 ? 202 BGC A O2  1 
HETATM 2347 O  O3  B BGC D 3 .   ? 27.78663  -0.83696  1.40227   0.323 19.45585 ? 202 BGC A O3  1 
HETATM 2348 O  O4  B BGC D 3 .   ? 29.23659  0.97515   -0.34794  0.323 19.68098 ? 202 BGC A O4  1 
HETATM 2349 O  O5  B BGC D 3 .   ? 29.95775  2.39636   2.95999   0.323 27.99434 ? 202 BGC A O5  1 
HETATM 2350 O  O6  B BGC D 3 .   ? 31.44314  3.97819   1.03860   0.323 33.19338 ? 202 BGC A O6  1 
HETATM 2351 CA CA  . CA  E 4 .   ? 5.94181   3.04172   -5.62199  1.000 14.63126 ? 203 CA  A CA  1 
HETATM 2352 CA CA  . CA  F 4 .   ? 27.52944  -0.84922  -1.15131  1.000 15.29650 ? 204 CA  A CA  1 
HETATM 2353 C  C1  A GLC G 2 .   ? 19.20484  20.37098  26.23666  0.602 25.94870 ? 201 GLC E C1  1 
HETATM 2354 C  C2  A GLC G 2 .   ? 18.05012  20.70216  27.24092  0.602 23.92247 ? 201 GLC E C2  1 
HETATM 2355 C  C3  A GLC G 2 .   ? 16.87688  21.52051  26.48792  0.602 21.11848 ? 201 GLC E C3  1 
HETATM 2356 C  C4  A GLC G 2 .   ? 17.47707  22.78084  25.81775  0.602 21.64082 ? 201 GLC E C4  1 
HETATM 2357 C  C5  A GLC G 2 .   ? 18.54673  22.20153  24.80738  0.602 21.71403 ? 201 GLC E C5  1 
HETATM 2358 C  C6  A GLC G 2 .   ? 19.17340  23.23666  23.88281  0.602 26.28470 ? 201 GLC E C6  1 
HETATM 2359 O  O1  A GLC G 2 .   ? 18.64648  19.51877  25.30813  0.602 30.40943 ? 201 GLC E O1  1 
HETATM 2360 O  O2  A GLC G 2 .   ? 17.58795  19.46447  27.64246  0.602 24.94179 ? 201 GLC E O2  1 
HETATM 2361 O  O3  A GLC G 2 .   ? 15.98980  22.00496  27.46527  0.602 19.85641 ? 201 GLC E O3  1 
HETATM 2362 O  O4  A GLC G 2 .   ? 16.40212  23.53569  25.21135  0.602 18.08507 ? 201 GLC E O4  1 
HETATM 2363 O  O5  A GLC G 2 .   ? 19.56362  21.53093  25.49652  0.602 26.50531 ? 201 GLC E O5  1 
HETATM 2364 O  O6  A GLC G 2 .   ? 20.54260  22.89699  23.68010  0.602 28.49336 ? 201 GLC E O6  1 
HETATM 2365 C  C2  B BGC H 3 .   ? 18.42176  22.42566  24.61253  0.440 21.64476 ? 202 BGC E C2  1 
HETATM 2366 C  C3  B BGC H 3 .   ? 17.44784  22.86894  25.75150  0.440 21.63627 ? 202 BGC E C3  1 
HETATM 2367 C  C4  B BGC H 3 .   ? 16.86082  21.59993  26.39348  0.440 21.12050 ? 202 BGC E C4  1 
HETATM 2368 C  C5  B BGC H 3 .   ? 18.11003  20.79967  26.94988  0.440 23.93873 ? 202 BGC E C5  1 
HETATM 2369 C  C6  B BGC H 3 .   ? 17.64828  19.49347  27.58519  0.440 24.89837 ? 202 BGC E C6  1 
HETATM 2370 C  C1  B BGC H 3 .   ? 19.54564  21.50045  25.20268  0.440 26.53852 ? 202 BGC E C1  1 
HETATM 2371 O  O1  B BGC H 3 .   ? 20.26601  20.96741  24.09847  0.440 26.34554 ? 202 BGC E O1  1 
HETATM 2372 O  O2  B BGC H 3 .   ? 18.98396  23.58033  24.08752  0.440 24.94749 ? 202 BGC E O2  1 
HETATM 2373 O  O3  B BGC H 3 .   ? 16.38073  23.64127  25.20191  0.440 18.11312 ? 202 BGC E O3  1 
HETATM 2374 O  O4  B BGC H 3 .   ? 16.00359  21.88369  27.46506  0.440 19.88860 ? 202 BGC E O4  1 
HETATM 2375 O  O5  B BGC H 3 .   ? 19.04282  20.40618  25.94674  0.440 25.99190 ? 202 BGC E O5  1 
HETATM 2376 O  O6  B BGC H 3 .   ? 18.77691  19.01263  28.23689  0.440 31.53738 ? 202 BGC E O6  1 
HETATM 2377 CA CA  . CA  I 4 .   ? -2.72003  19.84323  12.58629  1.000 17.97430 ? 203 CA  E CA  1 
HETATM 2378 CA CA  . CA  J 4 .   ? 14.28127  23.62138  26.62290  1.000 16.97618 ? 204 CA  E CA  1 
HETATM 2379 O  O   . HOH K 5 .   ? 4.45029   8.76242   -6.93565  1.000 39.66761 ? 301 HOH A O   1 
HETATM 2380 O  O   . HOH K 5 .   ? 26.88999  0.21302   6.83636   1.000 33.39038 ? 302 HOH A O   1 
HETATM 2381 O  O   . HOH K 5 .   ? 27.55787  -4.04452  3.87466   1.000 30.57862 ? 303 HOH A O   1 
HETATM 2382 O  O   . HOH K 5 .   ? 3.86090   -3.18722  -8.21409  1.000 26.67846 ? 304 HOH A O   1 
HETATM 2383 O  O   . HOH K 5 .   ? 24.63083  -15.59662 -9.04533  1.000 24.30456 ? 305 HOH A O   1 
HETATM 2384 O  O   . HOH K 5 .   ? 20.84427  -6.91693  12.12492  1.000 16.56032 ? 306 HOH A O   1 
HETATM 2385 O  O   . HOH K 5 .   ? 20.27586  -11.92345 -3.86772  1.000 21.60050 ? 307 HOH A O   1 
HETATM 2386 O  O   . HOH K 5 .   ? 33.72119  -2.48325  -3.76061  1.000 20.25851 ? 308 HOH A O   1 
HETATM 2387 O  O   . HOH K 5 .   ? 25.64710  2.26730   -10.70338 1.000 20.09844 ? 309 HOH A O   1 
HETATM 2388 O  O   . HOH K 5 .   ? 9.69020   13.24048  2.18311   1.000 22.01393 ? 310 HOH A O   1 
HETATM 2389 O  O   . HOH K 5 .   ? 11.05388  -1.20424  -13.40734 1.000 32.37169 ? 311 HOH A O   1 
HETATM 2390 O  O   . HOH K 5 .   ? 12.06918  6.47039   -11.51203 1.000 28.53224 ? 312 HOH A O   1 
HETATM 2391 O  O   . HOH K 5 .   ? 23.67313  -9.98249  1.71376   1.000 19.44539 ? 313 HOH A O   1 
HETATM 2392 O  O   . HOH K 5 .   ? 1.66223   -0.85406  9.98898   1.000 28.57195 ? 314 HOH A O   1 
HETATM 2393 O  O   . HOH K 5 .   ? 12.81960  3.93124   -10.19260 1.000 24.81719 ? 315 HOH A O   1 
HETATM 2394 O  O   . HOH K 5 .   ? 30.24140  4.50704   -2.75083  1.000 31.29117 ? 316 HOH A O   1 
HETATM 2395 O  O   . HOH K 5 .   ? -0.62538  3.30781   -7.79386  1.000 44.74550 ? 317 HOH A O   1 
HETATM 2396 O  O   . HOH K 5 .   ? 6.76682   -8.43714  11.93975  1.000 37.44525 ? 318 HOH A O   1 
HETATM 2397 O  O   . HOH K 5 .   ? 22.87482  1.24968   7.02307   1.000 21.06854 ? 319 HOH A O   1 
HETATM 2398 O  O   . HOH K 5 .   ? 5.48977   -1.92941  -2.01967  1.000 15.40924 ? 320 HOH A O   1 
HETATM 2399 O  O   . HOH K 5 .   ? 9.19267   -7.88573  11.20602  1.000 19.77695 ? 321 HOH A O   1 
HETATM 2400 O  O   . HOH K 5 .   ? 14.18746  15.09780  -1.78711  1.000 29.65441 ? 322 HOH A O   1 
HETATM 2401 O  O   . HOH K 5 .   ? 16.42314  -7.61925  -13.23287 1.000 30.85821 ? 323 HOH A O   1 
HETATM 2402 O  O   . HOH K 5 .   ? 18.23668  3.01887   9.29740   1.000 18.23815 ? 324 HOH A O   1 
HETATM 2403 O  O   . HOH K 5 .   ? 10.54295  2.37446   -16.00050 1.000 33.26063 ? 325 HOH A O   1 
HETATM 2404 O  O   . HOH K 5 .   ? 26.42090  -9.53148  -4.13952  1.000 27.82175 ? 326 HOH A O   1 
HETATM 2405 O  O   . HOH K 5 .   ? 14.55142  9.22557   -13.48808 1.000 35.54810 ? 327 HOH A O   1 
HETATM 2406 O  O   . HOH K 5 .   ? -2.11964  -2.75935  7.19380   1.000 33.02429 ? 328 HOH A O   1 
HETATM 2407 O  O   . HOH K 5 .   ? 1.09892   4.84811   -6.17644  1.000 23.20069 ? 329 HOH A O   1 
HETATM 2408 O  O   . HOH K 5 .   ? 7.19771   -1.58018  11.89694  1.000 21.85754 ? 330 HOH A O   1 
HETATM 2409 O  O   . HOH K 5 .   ? 4.51537   5.51601   9.42372   1.000 21.37397 ? 331 HOH A O   1 
HETATM 2410 O  O   . HOH K 5 .   ? 3.39210   7.88404   11.33406  1.000 27.45628 ? 332 HOH A O   1 
HETATM 2411 O  O   . HOH K 5 .   ? 20.22837  5.50379   13.14882  1.000 43.03916 ? 333 HOH A O   1 
HETATM 2412 O  O   . HOH K 5 .   ? 16.81260  -11.87872 8.64282   1.000 26.84072 ? 334 HOH A O   1 
HETATM 2413 O  O   . HOH K 5 .   ? -4.41604  -5.44201  3.79524   1.000 33.20653 ? 335 HOH A O   1 
HETATM 2414 O  O   . HOH K 5 .   ? -7.35076  -1.66781  2.55154   1.000 32.74563 ? 336 HOH A O   1 
HETATM 2415 O  O   . HOH K 5 .   ? 21.58378  5.05681   -10.77590 1.000 19.42915 ? 337 HOH A O   1 
HETATM 2416 O  O   . HOH K 5 .   ? 5.37507   -6.36176  -4.03775  1.000 19.18769 ? 338 HOH A O   1 
HETATM 2417 O  O   . HOH K 5 .   ? 3.34290   6.76713   -5.15099  1.000 18.45932 ? 339 HOH A O   1 
HETATM 2418 O  O   . HOH K 5 .   ? 15.65385  9.03271   3.27859   1.000 18.74336 ? 340 HOH A O   1 
HETATM 2419 O  O   . HOH K 5 .   ? 9.29808   -11.01724 -4.32784  1.000 22.59742 ? 341 HOH A O   1 
HETATM 2420 O  O   . HOH K 5 .   ? 0.24114   -2.45881  -3.27023  1.000 21.95335 ? 342 HOH A O   1 
HETATM 2421 O  O   . HOH K 5 .   ? 5.45518   10.68011  -9.98266  1.000 30.60985 ? 343 HOH A O   1 
HETATM 2422 O  O   . HOH K 5 .   ? 2.33488   -2.05230  14.25453  1.000 33.60873 ? 344 HOH A O   1 
HETATM 2423 O  O   . HOH K 5 .   ? 25.35931  -6.05382  -13.94853 1.000 29.15885 ? 345 HOH A O   1 
HETATM 2424 O  O   . HOH K 5 .   ? 18.10989  10.12439  2.07015   1.000 25.30707 ? 346 HOH A O   1 
HETATM 2425 O  O   . HOH K 5 .   ? 13.19514  0.69737   -11.69507 1.000 18.94549 ? 347 HOH A O   1 
HETATM 2426 O  O   . HOH K 5 .   ? 2.20848   -3.31555  -1.58721  1.000 19.87507 ? 348 HOH A O   1 
HETATM 2427 O  O   . HOH K 5 .   ? 6.42757   -1.62152  -10.11527 1.000 22.38407 ? 349 HOH A O   1 
HETATM 2428 O  O   . HOH K 5 .   ? 9.25632   -1.33880  -11.18391 1.000 23.24098 ? 350 HOH A O   1 
HETATM 2429 O  O   . HOH K 5 .   ? 4.80090   0.90838   -6.11516  1.000 14.67610 ? 351 HOH A O   1 
HETATM 2430 O  O   . HOH K 5 .   ? 24.64530  -3.94310  -10.72335 1.000 18.68541 ? 352 HOH A O   1 
HETATM 2431 O  O   . HOH K 5 .   ? 21.69859  -0.50715  -12.04622 1.000 29.10765 ? 353 HOH A O   1 
HETATM 2432 O  O   . HOH K 5 .   ? 14.54776  12.46550  -7.47965  1.000 30.05066 ? 354 HOH A O   1 
HETATM 2433 O  O   . HOH K 5 .   ? 29.08315  0.51996   -9.40357  1.000 26.41273 ? 355 HOH A O   1 
HETATM 2434 O  O   . HOH K 5 .   ? 10.13086  -5.46308  12.61566  1.000 20.07754 ? 356 HOH A O   1 
HETATM 2435 O  O   . HOH K 5 .   ? 6.04237   3.13375   13.06052  1.000 21.12466 ? 357 HOH A O   1 
HETATM 2436 O  O   . HOH K 5 .   ? 5.84642   6.74147   -8.32412  1.000 22.25671 ? 358 HOH A O   1 
HETATM 2437 O  O   . HOH K 5 .   ? 8.66201   14.50720  -4.39231  1.000 26.88611 ? 359 HOH A O   1 
HETATM 2438 O  O   . HOH K 5 .   ? 10.19678  9.76409   -13.24938 1.000 31.03568 ? 360 HOH A O   1 
HETATM 2439 O  O   . HOH K 5 .   ? 27.712    -10.603   -6.435    1.000 18.25157 ? 361 HOH A O   1 
HETATM 2440 O  O   . HOH K 5 .   ? 23.40826  -3.52498  11.32371  1.000 21.47377 ? 362 HOH A O   1 
HETATM 2441 O  O   . HOH K 5 .   ? 25.59010  10.34780  -4.60200  1.000 28.74755 ? 363 HOH A O   1 
HETATM 2442 O  O   . HOH K 5 .   ? 11.28822  -11.70441 3.87821   1.000 23.48845 ? 364 HOH A O   1 
HETATM 2443 O  O   . HOH K 5 .   ? 7.514     -0.367    13.792    1.000 22.91569 ? 365 HOH A O   1 
HETATM 2444 O  O   . HOH K 5 .   ? 10.59513  1.25008   -11.14777 1.000 22.94460 ? 366 HOH A O   1 
HETATM 2445 O  O   . HOH K 5 .   ? 18.47247  5.19866   -14.41467 1.000 30.29689 ? 367 HOH A O   1 
HETATM 2446 O  O   . HOH K 5 .   ? 8.29394   12.09744  -11.17945 1.000 23.48959 ? 368 HOH A O   1 
HETATM 2447 O  O   . HOH K 5 .   ? 19.48311  -4.93520  -13.07374 1.000 16.47424 ? 369 HOH A O   1 
HETATM 2448 O  O   . HOH K 5 .   ? 13.32162  -9.31741  -5.84648  1.000 25.77547 ? 370 HOH A O   1 
HETATM 2449 O  O   . HOH K 5 .   ? 11.79095  -12.03561 1.01960   1.000 21.19917 ? 371 HOH A O   1 
HETATM 2450 O  O   . HOH K 5 .   ? 17.55493  -13.97985 -5.65721  1.000 29.21802 ? 372 HOH A O   1 
HETATM 2451 O  O   . HOH K 5 .   ? 18.48146  7.12673   9.83520   1.000 26.40305 ? 373 HOH A O   1 
HETATM 2452 O  O   . HOH K 5 .   ? -12.41393 7.95916   -1.32732  1.000 40.94321 ? 374 HOH A O   1 
HETATM 2453 O  O   . HOH K 5 .   ? 25.40208  6.48367   -9.76773  1.000 34.26490 ? 375 HOH A O   1 
HETATM 2454 O  O   . HOH K 5 .   ? 22.18896  5.19295   9.27611   1.000 37.79515 ? 376 HOH A O   1 
HETATM 2455 O  O   . HOH K 5 .   ? 4.20748   4.44232   -6.77704  1.000 16.88690 ? 377 HOH A O   1 
HETATM 2456 O  O   . HOH K 5 .   ? -1.424    -9.746    4.396     1.000 27.67857 ? 378 HOH A O   1 
HETATM 2457 O  O   . HOH K 5 .   ? 15.58713  -10.37673 -6.54450  1.000 23.61180 ? 379 HOH A O   1 
HETATM 2458 O  O   . HOH K 5 .   ? 9.91107   18.25168  -0.07847  1.000 25.15793 ? 380 HOH A O   1 
HETATM 2459 O  O   . HOH K 5 .   ? 19.26833  5.22807   10.91091  1.000 33.13293 ? 381 HOH A O   1 
HETATM 2460 O  O   . HOH K 5 .   ? 4.54238   -0.54387  -8.51557  1.000 22.18794 ? 382 HOH A O   1 
HETATM 2461 O  O   . HOH K 5 .   ? 1.75556   7.36228   -8.94682  1.000 33.84987 ? 383 HOH A O   1 
HETATM 2462 O  O   . HOH K 5 .   ? 11.47298  -10.70820 -7.22454  1.000 29.66160 ? 384 HOH A O   1 
HETATM 2463 O  O   . HOH K 5 .   ? 3.56764   1.80321   -9.63100  1.000 29.09298 ? 385 HOH A O   1 
HETATM 2464 O  O   . HOH K 5 .   ? 3.82476   -0.77887  -4.03232  1.000 19.41218 ? 386 HOH A O   1 
HETATM 2465 O  O   . HOH K 5 .   ? 23.44569  -0.70520  8.36482   1.000 30.55761 ? 387 HOH A O   1 
HETATM 2466 O  O   . HOH K 5 .   ? 12.97553  -11.49892 -1.60196  1.000 31.17202 ? 388 HOH A O   1 
HETATM 2467 O  O   . HOH K 5 .   ? 11.90365  -10.14649 -3.38660  1.000 35.77838 ? 389 HOH A O   1 
HETATM 2468 O  O   . HOH K 5 .   ? 19.26763  -8.44992  13.81302  1.000 19.68872 ? 390 HOH A O   1 
HETATM 2469 O  O   . HOH K 5 .   ? 19.61164  -13.91072 -2.56360  1.000 39.17834 ? 391 HOH A O   1 
HETATM 2470 O  O   . HOH K 5 .   ? 23.40079  -2.00449  -12.01067 1.000 40.00982 ? 392 HOH A O   1 
HETATM 2471 O  O   . HOH K 5 .   ? 27.73268  -1.00381  -11.43570 1.000 22.86682 ? 393 HOH A O   1 
HETATM 2472 O  O   . HOH K 5 .   ? 10.70528  15.63013  -8.10837  1.000 34.48219 ? 394 HOH A O   1 
HETATM 2473 O  O   . HOH K 5 .   ? 0.62486   9.43973   -9.73097  1.000 40.81707 ? 395 HOH A O   1 
HETATM 2474 O  O   . HOH K 5 .   ? 25.11779  -0.03072  -12.07330 1.000 33.67079 ? 396 HOH A O   1 
HETATM 2475 O  O   . HOH K 5 .   ? 24.31787  4.51737   -11.51869 1.000 26.42431 ? 397 HOH A O   1 
HETATM 2476 O  O   . HOH K 5 .   ? 3.00958   -2.85632  -5.59829  1.000 31.97264 ? 398 HOH A O   1 
HETATM 2477 O  O   . HOH L 5 .   ? 13.41502  21.30521  -0.03235  1.000 26.08865 ? 301 HOH E O   1 
HETATM 2478 O  O   . HOH L 5 .   ? 19.66446  25.98631  24.54054  1.000 36.65740 ? 302 HOH E O   1 
HETATM 2479 O  O   . HOH L 5 .   ? -5.402    25.637    4.247     1.000 28.96938 ? 303 HOH E O   1 
HETATM 2480 O  O   . HOH L 5 .   ? 11.90894  24.42009  2.81414   1.000 24.55584 ? 304 HOH E O   1 
HETATM 2481 O  O   . HOH L 5 .   ? 5.77622   20.49704  31.23731  1.000 24.47608 ? 305 HOH E O   1 
HETATM 2482 O  O   . HOH L 5 .   ? 15.89555  25.27180  33.36526  1.000 21.38522 ? 306 HOH E O   1 
HETATM 2483 O  O   . HOH L 5 .   ? 20.47262  29.79764  13.18576  1.000 19.69670 ? 307 HOH E O   1 
HETATM 2484 O  O   . HOH L 5 .   ? 17.72731  21.50811  18.03483  1.000 22.36464 ? 308 HOH E O   1 
HETATM 2485 O  O   . HOH L 5 .   ? 6.30294   38.43443  29.31905  1.000 23.39927 ? 309 HOH E O   1 
HETATM 2486 O  O   . HOH L 5 .   ? -1.26896  26.65245  -0.59883  1.000 23.92154 ? 310 HOH E O   1 
HETATM 2487 O  O   . HOH L 5 .   ? -3.83688  16.06274  10.64136  1.000 32.98074 ? 311 HOH E O   1 
HETATM 2488 O  O   . HOH L 5 .   ? 14.06100  32.66372  21.79078  1.000 20.21730 ? 312 HOH E O   1 
HETATM 2489 O  O   . HOH L 5 .   ? 16.63164  19.84018  12.85758  1.000 15.36862 ? 313 HOH E O   1 
HETATM 2490 O  O   . HOH L 5 .   ? 15.31460  34.65410  11.96306  1.000 22.88715 ? 314 HOH E O   1 
HETATM 2491 O  O   . HOH L 5 .   ? 5.37938   9.51055   10.52415  1.000 22.81878 ? 315 HOH E O   1 
HETATM 2492 O  O   . HOH L 5 .   ? 19.407    31.006    8.253     1.000 16.00235 ? 316 HOH E O   1 
HETATM 2493 O  O   . HOH L 5 .   ? 8.98086   14.83941  0.31153   1.000 23.13216 ? 317 HOH E O   1 
HETATM 2494 O  O   . HOH L 5 .   ? 11.281    32.366    27.598    1.000 18.65053 ? 318 HOH E O   1 
HETATM 2495 O  O   . HOH L 5 .   ? -1.78469  29.33207  10.85274  1.000 22.76326 ? 319 HOH E O   1 
HETATM 2496 O  O   . HOH L 5 .   ? -0.12669  34.52654  29.05985  1.000 29.67580 ? 320 HOH E O   1 
HETATM 2497 O  O   . HOH L 5 .   ? -0.58259  31.13484  5.66873   1.000 22.55614 ? 321 HOH E O   1 
HETATM 2498 O  O   . HOH L 5 .   ? -1.95714  18.81425  20.83446  1.000 30.58606 ? 322 HOH E O   1 
HETATM 2499 O  O   . HOH L 5 .   ? 5.23464   7.64399   16.64957  1.000 25.10643 ? 323 HOH E O   1 
HETATM 2500 O  O   . HOH L 5 .   ? 12.48021  30.86917  4.57841   1.000 21.06014 ? 324 HOH E O   1 
HETATM 2501 O  O   . HOH L 5 .   ? 13.60780  23.09549  1.90511   1.000 27.79255 ? 325 HOH E O   1 
HETATM 2502 O  O   . HOH L 5 .   ? 10.26324  13.70602  14.51858  1.000 20.01907 ? 326 HOH E O   1 
HETATM 2503 O  O   . HOH L 5 .   ? 7.69308   34.71226  22.66920  1.000 20.85561 ? 327 HOH E O   1 
HETATM 2504 O  O   . HOH L 5 .   ? -0.19945  24.96805  9.83105   1.000 17.24914 ? 328 HOH E O   1 
HETATM 2505 O  O   . HOH L 5 .   ? 11.923    35.110    27.181    1.000 24.42531 ? 329 HOH E O   1 
HETATM 2506 O  O   . HOH L 5 .   ? -5.19275  17.16576  9.37378   1.000 38.91620 ? 330 HOH E O   1 
HETATM 2507 O  O   . HOH L 5 .   ? -0.52093  8.43925   13.86112  1.000 28.37925 ? 331 HOH E O   1 
HETATM 2508 O  O   . HOH L 5 .   ? 14.63668  18.29902  29.86611  1.000 29.03593 ? 332 HOH E O   1 
HETATM 2509 O  O   . HOH L 5 .   ? 9.517     26.619    32.069    1.000 14.17943 ? 333 HOH E O   1 
HETATM 2510 O  O   . HOH L 5 .   ? 2.91375   28.94682  32.89987  1.000 22.88667 ? 334 HOH E O   1 
HETATM 2511 O  O   . HOH L 5 .   ? -2.89141  22.10763  22.01549  1.000 18.97660 ? 335 HOH E O   1 
HETATM 2512 O  O   . HOH L 5 .   ? 10.59964  12.65811  27.27792  1.000 34.13455 ? 336 HOH E O   1 
HETATM 2513 O  O   . HOH L 5 .   ? 3.04987   17.68060  28.10854  1.000 20.83191 ? 337 HOH E O   1 
HETATM 2514 O  O   . HOH L 5 .   ? 5.09009   26.83958  30.38121  1.000 20.90358 ? 338 HOH E O   1 
HETATM 2515 O  O   . HOH L 5 .   ? 1.84550   31.88883  18.68223  1.000 25.40884 ? 339 HOH E O   1 
HETATM 2516 O  O   . HOH L 5 .   ? 8.96549   22.29030  33.07821  1.000 27.20213 ? 340 HOH E O   1 
HETATM 2517 O  O   . HOH L 5 .   ? 12.03551  19.48845  1.13750   1.000 22.43133 ? 341 HOH E O   1 
HETATM 2518 O  O   . HOH L 5 .   ? 14.32067  20.66560  33.07475  1.000 32.69800 ? 342 HOH E O   1 
HETATM 2519 O  O   . HOH L 5 .   ? 2.16726   23.24178  28.92989  1.000 32.00428 ? 343 HOH E O   1 
HETATM 2520 O  O   . HOH L 5 .   ? 8.38275   17.46084  2.09672   1.000 19.42543 ? 344 HOH E O   1 
HETATM 2521 O  O   . HOH L 5 .   ? -4.92629  24.03909  18.84703  1.000 29.14760 ? 345 HOH E O   1 
HETATM 2522 O  O   . HOH L 5 .   ? -3.72748  21.98427  11.95550  1.000 20.70245 ? 346 HOH E O   1 
HETATM 2523 O  O   . HOH L 5 .   ? 10.24722  33.31431  30.06215  1.000 18.35427 ? 347 HOH E O   1 
HETATM 2524 O  O   . HOH L 5 .   ? 9.54513   16.36406  -6.42111  1.000 35.43216 ? 348 HOH E O   1 
HETATM 2525 O  O   . HOH L 5 .   ? -11.63753 20.88748  -4.82672  1.000 37.38306 ? 349 HOH E O   1 
HETATM 2526 O  O   . HOH L 5 .   ? 2.38244   25.55074  -1.79076  1.000 26.62167 ? 350 HOH E O   1 
HETATM 2527 O  O   . HOH L 5 .   ? -3.24170  13.87250  24.68424  1.000 37.45385 ? 351 HOH E O   1 
HETATM 2528 O  O   . HOH L 5 .   ? -4.66972  18.46514  11.94660  1.000 20.97812 ? 352 HOH E O   1 
HETATM 2529 O  O   . HOH L 5 .   ? -5.51709  10.78153  18.19637  1.000 26.42221 ? 353 HOH E O   1 
HETATM 2530 O  O   . HOH L 5 .   ? 21.46011  26.23562  15.62626  1.000 22.80157 ? 354 HOH E O   1 
HETATM 2531 O  O   . HOH L 5 .   ? 4.96654   36.96085  21.71811  1.000 25.12516 ? 355 HOH E O   1 
HETATM 2532 O  O   . HOH L 5 .   ? -5.05191  15.93880  14.15454  1.000 29.75862 ? 356 HOH E O   1 
HETATM 2533 O  O   . HOH L 5 .   ? 10.81367  12.66001  17.23232  1.000 25.92667 ? 357 HOH E O   1 
HETATM 2534 O  O   . HOH L 5 .   ? 2.66884   33.07841  20.83159  1.000 26.16527 ? 358 HOH E O   1 
HETATM 2535 O  O   . HOH L 5 .   ? -0.05440  27.69193  27.78438  1.000 20.53374 ? 359 HOH E O   1 
HETATM 2536 O  O   . HOH L 5 .   ? -6.24304  19.59649  20.80022  1.000 34.72797 ? 360 HOH E O   1 
HETATM 2537 O  O   . HOH L 5 .   ? -6.16427  12.95436  20.67315  1.000 31.63624 ? 361 HOH E O   1 
HETATM 2538 O  O   . HOH L 5 .   ? 6.56708   16.38883  30.34387  1.000 32.92587 ? 362 HOH E O   1 
HETATM 2539 O  O   . HOH L 5 .   ? 20.97616  17.03181  11.25523  1.000 37.27121 ? 363 HOH E O   1 
HETATM 2540 O  O   . HOH L 5 .   ? 1.25938   10.43850  20.62661  1.000 35.65280 ? 364 HOH E O   1 
HETATM 2541 O  O   . HOH L 5 .   ? 0.65577   33.93186  14.66263  1.000 34.81095 ? 365 HOH E O   1 
HETATM 2542 O  O   . HOH L 5 .   ? -4.26901  21.37742  19.85371  1.000 32.87905 ? 366 HOH E O   1 
HETATM 2543 O  O   . HOH L 5 .   ? 17.08424  15.60956  12.62667  1.000 25.17818 ? 367 HOH E O   1 
HETATM 2544 O  O   . HOH L 5 .   ? 18.85524  33.71760  25.06308  1.000 29.35563 ? 368 HOH E O   1 
HETATM 2545 O  O   . HOH L 5 .   ? 16.23988  22.40500  33.30249  1.000 41.94881 ? 369 HOH E O   1 
HETATM 2546 O  O   . HOH L 5 .   ? 19.07422  23.63931  17.22173  1.000 26.50629 ? 370 HOH E O   1 
HETATM 2547 O  O   . HOH L 5 .   ? 11.13827  31.49060  2.32391   1.000 27.84062 ? 371 HOH E O   1 
HETATM 2548 O  O   . HOH L 5 .   ? -5.54455  23.67792  13.29103  1.000 25.11214 ? 372 HOH E O   1 
HETATM 2549 O  O   . HOH L 5 .   ? -0.25812  33.36904  17.65181  1.000 36.80261 ? 373 HOH E O   1 
HETATM 2550 O  O   . HOH L 5 .   ? 2.64029   7.15098   13.70658  1.000 26.39481 ? 374 HOH E O   1 
HETATM 2551 O  O   . HOH L 5 .   ? -2.79509  23.64759  10.07868  1.000 21.40445 ? 375 HOH E O   1 
HETATM 2552 O  O   . HOH L 5 .   ? 3.04587   32.93407  16.07669  1.000 30.07624 ? 376 HOH E O   1 
HETATM 2553 O  O   . HOH L 5 .   ? -3.855    30.622    3.407     1.000 24.11194 ? 377 HOH E O   1 
HETATM 2554 O  O   . HOH L 5 .   ? 20.95728  31.23441  10.89245  1.000 20.39227 ? 378 HOH E O   1 
HETATM 2555 O  O   . HOH L 5 .   ? 4.23213   22.59576  31.39626  1.000 33.87844 ? 379 HOH E O   1 
HETATM 2556 O  O   . HOH L 5 .   ? -2.14026  27.22220  9.66977   1.000 19.98632 ? 380 HOH E O   1 
HETATM 2557 O  O   . HOH L 5 .   ? 6.302     23.896    33.211    1.000 22.67006 ? 381 HOH E O   1 
HETATM 2558 O  O   . HOH L 5 .   ? 18.04572  35.26976  23.31854  1.000 49.36544 ? 382 HOH E O   1 
HETATM 2559 O  O   . HOH L 5 .   ? 4.29102   18.13820  30.54461  1.000 27.63650 ? 383 HOH E O   1 
# 
