data_9KO8
# 
_entry.id   9KO8 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9KO8         pdb_00009ko8 10.2210/pdb9ko8/pdb 
WWPDB D_1300053929 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-26 ? 
2 'Structure model' 1 1 2025-05-14 ? 
3 'Structure model' 1 2 2025-06-18 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Database references' 
2 3 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 3 'Structure model' citation        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_CSD'          
4  2 'Structure model' '_citation.journal_id_ISSN'         
5  2 'Structure model' '_citation.pdbx_database_id_DOI'    
6  2 'Structure model' '_citation.pdbx_database_id_PubMed' 
7  2 'Structure model' '_citation.title'                   
8  2 'Structure model' '_citation.year'                    
9  3 'Structure model' '_citation.journal_volume'          
10 3 'Structure model' '_citation.page_first'              
11 3 'Structure model' '_citation.page_last'               
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9KO8 
_pdbx_database_status.recvd_initial_deposition_date   2024-11-20 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        PDB 
_pdbx_database_related.details        . 
_pdbx_database_related.db_id          9KNS 
_pdbx_database_related.content_type   unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              bku@kribb.re.kr 
_pdbx_contact_author.name_first         Bonsu 
_pdbx_contact_author.name_last          Ku 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-1784-8975 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Ku, B.'    1 ? 
'Lee, H.S.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Embo Rep.' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1469-3178 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            26 
_citation.language                  ? 
_citation.page_first                2945 
_citation.page_last                 2966 
_citation.title                     
'Molecular basis for assembly and activation of the Hook3 - KIF1C complex-dependent transport machinery.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s44319-025-00458-w 
_citation.pdbx_database_id_PubMed   40312563 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Lee, H.S.'  1 0000-0002-9031-389X 
primary 'Yu, D.'     2 0000-0001-6317-8875 
primary 'Baek, K.E.' 3 0009-0004-2924-3847 
primary 'Shin, H.C.' 4 0000-0001-7878-0367 
primary 'Kim, S.J.'  5 0000-0003-0293-6972 
primary 'Do Heo, W.' 6 0000-0001-7541-7319 
primary 'Ku, B.'     7 0000-0003-1784-8975 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Kinesin-like protein KIF1C' 11343.092 2  ? ? ? ? 
2 polymer man 'Protein Hook homolog 3'     9101.422  2  ? ? ? ? 
3 water   nat water                        18.015    27 ? ? ? ? 
# 
_entity_name_com.entity_id   2 
_entity_name_com.name        h-hook3,hHK3 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;GHMPSSGKRRAPRRVYQIPQRRRLQGKDPRWATMADLKMQAVKEICYEVALADFRHGRAEIEALAALKMRELCRTYGKPD
GPGDAWRAVARDVWDTVGE
;
;GHMPSSGKRRAPRRVYQIPQRRRLQGKDPRWATMADLKMQAVKEICYEVALADFRHGRAEIEALAALKMRELCRTYGKPD
GPGDAWRAVARDVWDTVGE
;
A,B ? 
2 'polypeptide(L)' no no GHMEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQ                            
GHMEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQ                            C,D ? 
# 
_pdbx_entity_nonpoly.entity_id   3 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1  GLY n 
1 2  HIS n 
1 3  MET n 
1 4  PRO n 
1 5  SER n 
1 6  SER n 
1 7  GLY n 
1 8  LYS n 
1 9  ARG n 
1 10 ARG n 
1 11 ALA n 
1 12 PRO n 
1 13 ARG n 
1 14 ARG n 
1 15 VAL n 
1 16 TYR n 
1 17 GLN n 
1 18 ILE n 
1 19 PRO n 
1 20 GLN n 
1 21 ARG n 
1 22 ARG n 
1 23 ARG n 
1 24 LEU n 
1 25 GLN n 
1 26 GLY n 
1 27 LYS n 
1 28 ASP n 
1 29 PRO n 
1 30 ARG n 
1 31 TRP n 
1 32 ALA n 
1 33 THR n 
1 34 MET n 
1 35 ALA n 
1 36 ASP n 
1 37 LEU n 
1 38 LYS n 
1 39 MET n 
1 40 GLN n 
1 41 ALA n 
1 42 VAL n 
1 43 LYS n 
1 44 GLU n 
1 45 ILE n 
1 46 CYS n 
1 47 TYR n 
1 48 GLU n 
1 49 VAL n 
1 50 ALA n 
1 51 LEU n 
1 52 ALA n 
1 53 ASP n 
1 54 PHE n 
1 55 ARG n 
1 56 HIS n 
1 57 GLY n 
1 58 ARG n 
1 59 ALA n 
1 60 GLU n 
1 61 ILE n 
1 62 GLU n 
1 63 ALA n 
1 64 LEU n 
1 65 ALA n 
1 66 ALA n 
1 67 LEU n 
1 68 LYS n 
1 69 MET n 
1 70 ARG n 
1 71 GLU n 
1 72 LEU n 
1 73 CYS n 
1 74 ARG n 
1 75 THR n 
1 76 TYR n 
1 77 GLY n 
1 78 LYS n 
1 79 PRO n 
1 80 ASP n 
1 81 GLY n 
1 82 PRO n 
1 83 GLY n 
1 84 ASP n 
1 85 ALA n 
1 86 TRP n 
1 87 ARG n 
1 88 ALA n 
1 89 VAL n 
1 90 ALA n 
1 91 ARG n 
1 92 ASP n 
1 93 VAL n 
1 94 TRP n 
1 95 ASP n 
1 96 THR n 
1 97 VAL n 
1 98 GLY n 
1 99 GLU n 
2 1  GLY n 
2 2  HIS n 
2 3  MET n 
2 4  GLU n 
2 5  LYS n 
2 6  LEU n 
2 7  HIS n 
2 8  GLU n 
2 9  ALA n 
2 10 ASN n 
2 11 ASN n 
2 12 GLU n 
2 13 LEU n 
2 14 GLN n 
2 15 LYS n 
2 16 LYS n 
2 17 ARG n 
2 18 ALA n 
2 19 ILE n 
2 20 ILE n 
2 21 GLU n 
2 22 ASP n 
2 23 LEU n 
2 24 GLU n 
2 25 PRO n 
2 26 ARG n 
2 27 PHE n 
2 28 ASN n 
2 29 ASN n 
2 30 SER n 
2 31 SER n 
2 32 LEU n 
2 33 LYS n 
2 34 ILE n 
2 35 GLU n 
2 36 GLU n 
2 37 LEU n 
2 38 GLN n 
2 39 GLU n 
2 40 ALA n 
2 41 LEU n 
2 42 ARG n 
2 43 LYS n 
2 44 LYS n 
2 45 GLU n 
2 46 GLU n 
2 47 GLU n 
2 48 MET n 
2 49 LYS n 
2 50 GLN n 
2 51 MET n 
2 52 GLU n 
2 53 GLU n 
2 54 ARG n 
2 55 TYR n 
2 56 LYS n 
2 57 LYS n 
2 58 TYR n 
2 59 LEU n 
2 60 GLU n 
2 61 LYS n 
2 62 ALA n 
2 63 LYS n 
2 64 SER n 
2 65 VAL n 
2 66 ILE n 
2 67 ARG n 
2 68 THR n 
2 69 LEU n 
2 70 ASP n 
2 71 PRO n 
2 72 LYS n 
2 73 GLN n 
2 74 ASN n 
2 75 GLN n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 99 human ? 'KIF1C, KIAA0706' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Escherichia coli' 
562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 75 human ? HOOK3             ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Escherichia coli' 
562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1  GLY 1  711 ?   ?   ?   A . n 
A 1 2  HIS 2  712 ?   ?   ?   A . n 
A 1 3  MET 3  713 ?   ?   ?   A . n 
A 1 4  PRO 4  714 ?   ?   ?   A . n 
A 1 5  SER 5  715 ?   ?   ?   A . n 
A 1 6  SER 6  716 ?   ?   ?   A . n 
A 1 7  GLY 7  717 ?   ?   ?   A . n 
A 1 8  LYS 8  718 ?   ?   ?   A . n 
A 1 9  ARG 9  719 ?   ?   ?   A . n 
A 1 10 ARG 10 720 ?   ?   ?   A . n 
A 1 11 ALA 11 721 ?   ?   ?   A . n 
A 1 12 PRO 12 722 ?   ?   ?   A . n 
A 1 13 ARG 13 723 ?   ?   ?   A . n 
A 1 14 ARG 14 724 ?   ?   ?   A . n 
A 1 15 VAL 15 725 ?   ?   ?   A . n 
A 1 16 TYR 16 726 ?   ?   ?   A . n 
A 1 17 GLN 17 727 ?   ?   ?   A . n 
A 1 18 ILE 18 728 ?   ?   ?   A . n 
A 1 19 PRO 19 729 ?   ?   ?   A . n 
A 1 20 GLN 20 730 ?   ?   ?   A . n 
A 1 21 ARG 21 731 ?   ?   ?   A . n 
A 1 22 ARG 22 732 ?   ?   ?   A . n 
A 1 23 ARG 23 733 ?   ?   ?   A . n 
A 1 24 LEU 24 734 ?   ?   ?   A . n 
A 1 25 GLN 25 735 ?   ?   ?   A . n 
A 1 26 GLY 26 736 ?   ?   ?   A . n 
A 1 27 LYS 27 737 ?   ?   ?   A . n 
A 1 28 ASP 28 738 ?   ?   ?   A . n 
A 1 29 PRO 29 739 ?   ?   ?   A . n 
A 1 30 ARG 30 740 ?   ?   ?   A . n 
A 1 31 TRP 31 741 ?   ?   ?   A . n 
A 1 32 ALA 32 742 742 ALA ALA A . n 
A 1 33 THR 33 743 743 THR THR A . n 
A 1 34 MET 34 744 744 MET MET A . n 
A 1 35 ALA 35 745 745 ALA ALA A . n 
A 1 36 ASP 36 746 746 ASP ASP A . n 
A 1 37 LEU 37 747 747 LEU LEU A . n 
A 1 38 LYS 38 748 748 LYS LYS A . n 
A 1 39 MET 39 749 749 MET MET A . n 
A 1 40 GLN 40 750 750 GLN GLN A . n 
A 1 41 ALA 41 751 751 ALA ALA A . n 
A 1 42 VAL 42 752 752 VAL VAL A . n 
A 1 43 LYS 43 753 753 LYS LYS A . n 
A 1 44 GLU 44 754 754 GLU GLU A . n 
A 1 45 ILE 45 755 755 ILE ILE A . n 
A 1 46 CYS 46 756 756 CYS CYS A . n 
A 1 47 TYR 47 757 757 TYR TYR A . n 
A 1 48 GLU 48 758 758 GLU GLU A . n 
A 1 49 VAL 49 759 759 VAL VAL A . n 
A 1 50 ALA 50 760 760 ALA ALA A . n 
A 1 51 LEU 51 761 761 LEU LEU A . n 
A 1 52 ALA 52 762 762 ALA ALA A . n 
A 1 53 ASP 53 763 763 ASP ASP A . n 
A 1 54 PHE 54 764 764 PHE PHE A . n 
A 1 55 ARG 55 765 765 ARG ARG A . n 
A 1 56 HIS 56 766 766 HIS HIS A . n 
A 1 57 GLY 57 767 767 GLY GLY A . n 
A 1 58 ARG 58 768 768 ARG ARG A . n 
A 1 59 ALA 59 769 769 ALA ALA A . n 
A 1 60 GLU 60 770 770 GLU GLU A . n 
A 1 61 ILE 61 771 771 ILE ILE A . n 
A 1 62 GLU 62 772 772 GLU GLU A . n 
A 1 63 ALA 63 773 773 ALA ALA A . n 
A 1 64 LEU 64 774 774 LEU LEU A . n 
A 1 65 ALA 65 775 775 ALA ALA A . n 
A 1 66 ALA 66 776 776 ALA ALA A . n 
A 1 67 LEU 67 777 777 LEU LEU A . n 
A 1 68 LYS 68 778 778 LYS LYS A . n 
A 1 69 MET 69 779 779 MET MET A . n 
A 1 70 ARG 70 780 780 ARG ARG A . n 
A 1 71 GLU 71 781 781 GLU GLU A . n 
A 1 72 LEU 72 782 782 LEU LEU A . n 
A 1 73 CYS 73 783 783 CYS CYS A . n 
A 1 74 ARG 74 784 784 ARG ARG A . n 
A 1 75 THR 75 785 785 THR THR A . n 
A 1 76 TYR 76 786 786 TYR TYR A . n 
A 1 77 GLY 77 787 ?   ?   ?   A . n 
A 1 78 LYS 78 788 ?   ?   ?   A . n 
A 1 79 PRO 79 789 ?   ?   ?   A . n 
A 1 80 ASP 80 790 ?   ?   ?   A . n 
A 1 81 GLY 81 791 ?   ?   ?   A . n 
A 1 82 PRO 82 792 ?   ?   ?   A . n 
A 1 83 GLY 83 793 793 GLY GLY A . n 
A 1 84 ASP 84 794 794 ASP ASP A . n 
A 1 85 ALA 85 795 795 ALA ALA A . n 
A 1 86 TRP 86 796 796 TRP TRP A . n 
A 1 87 ARG 87 797 797 ARG ARG A . n 
A 1 88 ALA 88 798 798 ALA ALA A . n 
A 1 89 VAL 89 799 799 VAL VAL A . n 
A 1 90 ALA 90 800 800 ALA ALA A . n 
A 1 91 ARG 91 801 801 ARG ARG A . n 
A 1 92 ASP 92 802 802 ASP ASP A . n 
A 1 93 VAL 93 803 803 VAL VAL A . n 
A 1 94 TRP 94 804 804 TRP TRP A . n 
A 1 95 ASP 95 805 805 ASP ASP A . n 
A 1 96 THR 96 806 806 THR THR A . n 
A 1 97 VAL 97 807 807 VAL VAL A . n 
A 1 98 GLY 98 808 808 GLY GLY A . n 
A 1 99 GLU 99 809 ?   ?   ?   A . n 
B 1 1  GLY 1  711 ?   ?   ?   B . n 
B 1 2  HIS 2  712 ?   ?   ?   B . n 
B 1 3  MET 3  713 ?   ?   ?   B . n 
B 1 4  PRO 4  714 ?   ?   ?   B . n 
B 1 5  SER 5  715 ?   ?   ?   B . n 
B 1 6  SER 6  716 ?   ?   ?   B . n 
B 1 7  GLY 7  717 ?   ?   ?   B . n 
B 1 8  LYS 8  718 ?   ?   ?   B . n 
B 1 9  ARG 9  719 ?   ?   ?   B . n 
B 1 10 ARG 10 720 ?   ?   ?   B . n 
B 1 11 ALA 11 721 ?   ?   ?   B . n 
B 1 12 PRO 12 722 ?   ?   ?   B . n 
B 1 13 ARG 13 723 ?   ?   ?   B . n 
B 1 14 ARG 14 724 ?   ?   ?   B . n 
B 1 15 VAL 15 725 ?   ?   ?   B . n 
B 1 16 TYR 16 726 ?   ?   ?   B . n 
B 1 17 GLN 17 727 ?   ?   ?   B . n 
B 1 18 ILE 18 728 ?   ?   ?   B . n 
B 1 19 PRO 19 729 ?   ?   ?   B . n 
B 1 20 GLN 20 730 ?   ?   ?   B . n 
B 1 21 ARG 21 731 ?   ?   ?   B . n 
B 1 22 ARG 22 732 ?   ?   ?   B . n 
B 1 23 ARG 23 733 ?   ?   ?   B . n 
B 1 24 LEU 24 734 ?   ?   ?   B . n 
B 1 25 GLN 25 735 ?   ?   ?   B . n 
B 1 26 GLY 26 736 ?   ?   ?   B . n 
B 1 27 LYS 27 737 ?   ?   ?   B . n 
B 1 28 ASP 28 738 ?   ?   ?   B . n 
B 1 29 PRO 29 739 ?   ?   ?   B . n 
B 1 30 ARG 30 740 ?   ?   ?   B . n 
B 1 31 TRP 31 741 ?   ?   ?   B . n 
B 1 32 ALA 32 742 742 ALA ALA B . n 
B 1 33 THR 33 743 743 THR THR B . n 
B 1 34 MET 34 744 744 MET MET B . n 
B 1 35 ALA 35 745 745 ALA ALA B . n 
B 1 36 ASP 36 746 746 ASP ASP B . n 
B 1 37 LEU 37 747 747 LEU LEU B . n 
B 1 38 LYS 38 748 748 LYS LYS B . n 
B 1 39 MET 39 749 749 MET MET B . n 
B 1 40 GLN 40 750 750 GLN GLN B . n 
B 1 41 ALA 41 751 751 ALA ALA B . n 
B 1 42 VAL 42 752 752 VAL VAL B . n 
B 1 43 LYS 43 753 753 LYS LYS B . n 
B 1 44 GLU 44 754 754 GLU GLU B . n 
B 1 45 ILE 45 755 755 ILE ILE B . n 
B 1 46 CYS 46 756 756 CYS CYS B . n 
B 1 47 TYR 47 757 757 TYR TYR B . n 
B 1 48 GLU 48 758 758 GLU GLU B . n 
B 1 49 VAL 49 759 759 VAL VAL B . n 
B 1 50 ALA 50 760 760 ALA ALA B . n 
B 1 51 LEU 51 761 761 LEU LEU B . n 
B 1 52 ALA 52 762 762 ALA ALA B . n 
B 1 53 ASP 53 763 763 ASP ASP B . n 
B 1 54 PHE 54 764 764 PHE PHE B . n 
B 1 55 ARG 55 765 765 ARG ARG B . n 
B 1 56 HIS 56 766 766 HIS HIS B . n 
B 1 57 GLY 57 767 767 GLY GLY B . n 
B 1 58 ARG 58 768 768 ARG ARG B . n 
B 1 59 ALA 59 769 769 ALA ALA B . n 
B 1 60 GLU 60 770 770 GLU GLU B . n 
B 1 61 ILE 61 771 771 ILE ILE B . n 
B 1 62 GLU 62 772 772 GLU GLU B . n 
B 1 63 ALA 63 773 773 ALA ALA B . n 
B 1 64 LEU 64 774 774 LEU LEU B . n 
B 1 65 ALA 65 775 775 ALA ALA B . n 
B 1 66 ALA 66 776 776 ALA ALA B . n 
B 1 67 LEU 67 777 777 LEU LEU B . n 
B 1 68 LYS 68 778 778 LYS LYS B . n 
B 1 69 MET 69 779 779 MET MET B . n 
B 1 70 ARG 70 780 780 ARG ARG B . n 
B 1 71 GLU 71 781 781 GLU GLU B . n 
B 1 72 LEU 72 782 782 LEU LEU B . n 
B 1 73 CYS 73 783 783 CYS CYS B . n 
B 1 74 ARG 74 784 784 ARG ARG B . n 
B 1 75 THR 75 785 785 THR THR B . n 
B 1 76 TYR 76 786 786 TYR TYR B . n 
B 1 77 GLY 77 787 ?   ?   ?   B . n 
B 1 78 LYS 78 788 ?   ?   ?   B . n 
B 1 79 PRO 79 789 ?   ?   ?   B . n 
B 1 80 ASP 80 790 ?   ?   ?   B . n 
B 1 81 GLY 81 791 ?   ?   ?   B . n 
B 1 82 PRO 82 792 ?   ?   ?   B . n 
B 1 83 GLY 83 793 793 GLY GLY B . n 
B 1 84 ASP 84 794 794 ASP ASP B . n 
B 1 85 ALA 85 795 795 ALA ALA B . n 
B 1 86 TRP 86 796 796 TRP TRP B . n 
B 1 87 ARG 87 797 797 ARG ARG B . n 
B 1 88 ALA 88 798 798 ALA ALA B . n 
B 1 89 VAL 89 799 799 VAL VAL B . n 
B 1 90 ALA 90 800 800 ALA ALA B . n 
B 1 91 ARG 91 801 801 ARG ARG B . n 
B 1 92 ASP 92 802 802 ASP ASP B . n 
B 1 93 VAL 93 803 803 VAL VAL B . n 
B 1 94 TRP 94 804 804 TRP TRP B . n 
B 1 95 ASP 95 805 805 ASP ASP B . n 
B 1 96 THR 96 806 806 THR THR B . n 
B 1 97 VAL 97 807 807 VAL VAL B . n 
B 1 98 GLY 98 808 808 GLY GLY B . n 
B 1 99 GLU 99 809 ?   ?   ?   B . n 
C 2 1  GLY 1  550 ?   ?   ?   C . n 
C 2 2  HIS 2  551 ?   ?   ?   C . n 
C 2 3  MET 3  552 552 MET MET C . n 
C 2 4  GLU 4  553 553 GLU GLU C . n 
C 2 5  LYS 5  554 554 LYS LYS C . n 
C 2 6  LEU 6  555 555 LEU LEU C . n 
C 2 7  HIS 7  556 556 HIS HIS C . n 
C 2 8  GLU 8  557 557 GLU GLU C . n 
C 2 9  ALA 9  558 558 ALA ALA C . n 
C 2 10 ASN 10 559 559 ASN ASN C . n 
C 2 11 ASN 11 560 560 ASN ASN C . n 
C 2 12 GLU 12 561 561 GLU GLU C . n 
C 2 13 LEU 13 562 562 LEU LEU C . n 
C 2 14 GLN 14 563 563 GLN GLN C . n 
C 2 15 LYS 15 564 564 LYS LYS C . n 
C 2 16 LYS 16 565 565 LYS LYS C . n 
C 2 17 ARG 17 566 566 ARG ARG C . n 
C 2 18 ALA 18 567 567 ALA ALA C . n 
C 2 19 ILE 19 568 568 ILE ILE C . n 
C 2 20 ILE 20 569 569 ILE ILE C . n 
C 2 21 GLU 21 570 570 GLU GLU C . n 
C 2 22 ASP 22 571 571 ASP ASP C . n 
C 2 23 LEU 23 572 572 LEU LEU C . n 
C 2 24 GLU 24 573 573 GLU GLU C . n 
C 2 25 PRO 25 574 574 PRO PRO C . n 
C 2 26 ARG 26 575 575 ARG ARG C . n 
C 2 27 PHE 27 576 576 PHE PHE C . n 
C 2 28 ASN 28 577 577 ASN ASN C . n 
C 2 29 ASN 29 578 578 ASN ASN C . n 
C 2 30 SER 30 579 579 SER SER C . n 
C 2 31 SER 31 580 580 SER SER C . n 
C 2 32 LEU 32 581 581 LEU LEU C . n 
C 2 33 LYS 33 582 582 LYS LYS C . n 
C 2 34 ILE 34 583 583 ILE ILE C . n 
C 2 35 GLU 35 584 584 GLU GLU C . n 
C 2 36 GLU 36 585 585 GLU GLU C . n 
C 2 37 LEU 37 586 586 LEU LEU C . n 
C 2 38 GLN 38 587 587 GLN GLN C . n 
C 2 39 GLU 39 588 588 GLU GLU C . n 
C 2 40 ALA 40 589 589 ALA ALA C . n 
C 2 41 LEU 41 590 590 LEU LEU C . n 
C 2 42 ARG 42 591 591 ARG ARG C . n 
C 2 43 LYS 43 592 592 LYS LYS C . n 
C 2 44 LYS 44 593 593 LYS LYS C . n 
C 2 45 GLU 45 594 594 GLU GLU C . n 
C 2 46 GLU 46 595 595 GLU GLU C . n 
C 2 47 GLU 47 596 596 GLU GLU C . n 
C 2 48 MET 48 597 597 MET MET C . n 
C 2 49 LYS 49 598 598 LYS LYS C . n 
C 2 50 GLN 50 599 599 GLN GLN C . n 
C 2 51 MET 51 600 600 MET MET C . n 
C 2 52 GLU 52 601 601 GLU GLU C . n 
C 2 53 GLU 53 602 602 GLU GLU C . n 
C 2 54 ARG 54 603 603 ARG ARG C . n 
C 2 55 TYR 55 604 604 TYR TYR C . n 
C 2 56 LYS 56 605 605 LYS LYS C . n 
C 2 57 LYS 57 606 606 LYS LYS C . n 
C 2 58 TYR 58 607 607 TYR TYR C . n 
C 2 59 LEU 59 608 608 LEU LEU C . n 
C 2 60 GLU 60 609 609 GLU GLU C . n 
C 2 61 LYS 61 610 610 LYS LYS C . n 
C 2 62 ALA 62 611 611 ALA ALA C . n 
C 2 63 LYS 63 612 612 LYS LYS C . n 
C 2 64 SER 64 613 613 SER SER C . n 
C 2 65 VAL 65 614 614 VAL VAL C . n 
C 2 66 ILE 66 615 615 ILE ILE C . n 
C 2 67 ARG 67 616 616 ARG ARG C . n 
C 2 68 THR 68 617 617 THR THR C . n 
C 2 69 LEU 69 618 618 LEU LEU C . n 
C 2 70 ASP 70 619 619 ASP ASP C . n 
C 2 71 PRO 71 620 620 PRO PRO C . n 
C 2 72 LYS 72 621 621 LYS LYS C . n 
C 2 73 GLN 73 622 622 GLN GLN C . n 
C 2 74 ASN 74 623 ?   ?   ?   C . n 
C 2 75 GLN 75 624 ?   ?   ?   C . n 
D 2 1  GLY 1  550 ?   ?   ?   D . n 
D 2 2  HIS 2  551 ?   ?   ?   D . n 
D 2 3  MET 3  552 552 MET MET D . n 
D 2 4  GLU 4  553 553 GLU GLU D . n 
D 2 5  LYS 5  554 554 LYS LYS D . n 
D 2 6  LEU 6  555 555 LEU LEU D . n 
D 2 7  HIS 7  556 556 HIS HIS D . n 
D 2 8  GLU 8  557 557 GLU GLU D . n 
D 2 9  ALA 9  558 558 ALA ALA D . n 
D 2 10 ASN 10 559 559 ASN ASN D . n 
D 2 11 ASN 11 560 560 ASN ASN D . n 
D 2 12 GLU 12 561 561 GLU GLU D . n 
D 2 13 LEU 13 562 562 LEU LEU D . n 
D 2 14 GLN 14 563 563 GLN GLN D . n 
D 2 15 LYS 15 564 564 LYS LYS D . n 
D 2 16 LYS 16 565 565 LYS LYS D . n 
D 2 17 ARG 17 566 566 ARG ARG D . n 
D 2 18 ALA 18 567 567 ALA ALA D . n 
D 2 19 ILE 19 568 568 ILE ILE D . n 
D 2 20 ILE 20 569 569 ILE ILE D . n 
D 2 21 GLU 21 570 570 GLU GLU D . n 
D 2 22 ASP 22 571 571 ASP ASP D . n 
D 2 23 LEU 23 572 572 LEU LEU D . n 
D 2 24 GLU 24 573 573 GLU GLU D . n 
D 2 25 PRO 25 574 574 PRO PRO D . n 
D 2 26 ARG 26 575 575 ARG ARG D . n 
D 2 27 PHE 27 576 576 PHE PHE D . n 
D 2 28 ASN 28 577 577 ASN ASN D . n 
D 2 29 ASN 29 578 578 ASN ASN D . n 
D 2 30 SER 30 579 579 SER SER D . n 
D 2 31 SER 31 580 580 SER SER D . n 
D 2 32 LEU 32 581 581 LEU LEU D . n 
D 2 33 LYS 33 582 582 LYS LYS D . n 
D 2 34 ILE 34 583 583 ILE ILE D . n 
D 2 35 GLU 35 584 584 GLU GLU D . n 
D 2 36 GLU 36 585 585 GLU GLU D . n 
D 2 37 LEU 37 586 586 LEU LEU D . n 
D 2 38 GLN 38 587 587 GLN GLN D . n 
D 2 39 GLU 39 588 588 GLU GLU D . n 
D 2 40 ALA 40 589 589 ALA ALA D . n 
D 2 41 LEU 41 590 590 LEU LEU D . n 
D 2 42 ARG 42 591 591 ARG ARG D . n 
D 2 43 LYS 43 592 592 LYS LYS D . n 
D 2 44 LYS 44 593 593 LYS LYS D . n 
D 2 45 GLU 45 594 594 GLU GLU D . n 
D 2 46 GLU 46 595 595 GLU GLU D . n 
D 2 47 GLU 47 596 596 GLU GLU D . n 
D 2 48 MET 48 597 597 MET MET D . n 
D 2 49 LYS 49 598 598 LYS LYS D . n 
D 2 50 GLN 50 599 599 GLN GLN D . n 
D 2 51 MET 51 600 600 MET MET D . n 
D 2 52 GLU 52 601 601 GLU GLU D . n 
D 2 53 GLU 53 602 602 GLU GLU D . n 
D 2 54 ARG 54 603 603 ARG ARG D . n 
D 2 55 TYR 55 604 604 TYR TYR D . n 
D 2 56 LYS 56 605 605 LYS LYS D . n 
D 2 57 LYS 57 606 606 LYS LYS D . n 
D 2 58 TYR 58 607 607 TYR TYR D . n 
D 2 59 LEU 59 608 608 LEU LEU D . n 
D 2 60 GLU 60 609 609 GLU GLU D . n 
D 2 61 LYS 61 610 610 LYS LYS D . n 
D 2 62 ALA 62 611 611 ALA ALA D . n 
D 2 63 LYS 63 612 612 LYS LYS D . n 
D 2 64 SER 64 613 613 SER SER D . n 
D 2 65 VAL 65 614 614 VAL VAL D . n 
D 2 66 ILE 66 615 615 ILE ILE D . n 
D 2 67 ARG 67 616 616 ARG ARG D . n 
D 2 68 THR 68 617 617 THR THR D . n 
D 2 69 LEU 69 618 618 LEU LEU D . n 
D 2 70 ASP 70 619 619 ASP ASP D . n 
D 2 71 PRO 71 620 620 PRO PRO D . n 
D 2 72 LYS 72 621 621 LYS LYS D . n 
D 2 73 GLN 73 622 622 GLN GLN D . n 
D 2 74 ASN 74 623 ?   ?   ?   D . n 
D 2 75 GLN 75 624 ?   ?   ?   D . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
E 3 HOH 1  901 21 HOH HOH A . 
E 3 HOH 2  902 27 HOH HOH A . 
E 3 HOH 3  903 3  HOH HOH A . 
E 3 HOH 4  904 2  HOH HOH A . 
E 3 HOH 5  905 1  HOH HOH A . 
E 3 HOH 6  906 20 HOH HOH A . 
F 3 HOH 1  901 4  HOH HOH B . 
F 3 HOH 2  902 23 HOH HOH B . 
F 3 HOH 3  903 15 HOH HOH B . 
F 3 HOH 4  904 22 HOH HOH B . 
G 3 HOH 1  701 17 HOH HOH C . 
G 3 HOH 2  702 10 HOH HOH C . 
G 3 HOH 3  703 12 HOH HOH C . 
G 3 HOH 4  704 18 HOH HOH C . 
G 3 HOH 5  705 11 HOH HOH C . 
G 3 HOH 6  706 26 HOH HOH C . 
G 3 HOH 7  707 13 HOH HOH C . 
G 3 HOH 8  708 7  HOH HOH C . 
G 3 HOH 9  709 8  HOH HOH C . 
G 3 HOH 10 710 6  HOH HOH C . 
G 3 HOH 11 711 5  HOH HOH C . 
H 3 HOH 1  701 24 HOH HOH D . 
H 3 HOH 2  702 14 HOH HOH D . 
H 3 HOH 3  703 16 HOH HOH D . 
H 3 HOH 4  704 9  HOH HOH D . 
H 3 HOH 5  705 25 HOH HOH D . 
H 3 HOH 6  706 19 HOH HOH D . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 B ARG 765 ? NE  ? B ARG 55 NE  
2  1 Y 1 B ARG 765 ? CZ  ? B ARG 55 CZ  
3  1 Y 1 B ARG 765 ? NH1 ? B ARG 55 NH1 
4  1 Y 1 B ARG 765 ? NH2 ? B ARG 55 NH2 
5  1 Y 1 B LYS 778 ? CE  ? B LYS 68 CE  
6  1 Y 1 B LYS 778 ? NZ  ? B LYS 68 NZ  
7  1 Y 1 C LEU 555 ? CG  ? C LEU 6  CG  
8  1 Y 1 C LEU 555 ? CD1 ? C LEU 6  CD1 
9  1 Y 1 C LEU 555 ? CD2 ? C LEU 6  CD2 
10 1 Y 1 C LYS 564 ? CD  ? C LYS 15 CD  
11 1 Y 1 C LYS 564 ? CE  ? C LYS 15 CE  
12 1 Y 1 C LYS 564 ? NZ  ? C LYS 15 NZ  
13 1 Y 1 C GLU 594 ? CG  ? C GLU 45 CG  
14 1 Y 1 C GLU 594 ? CD  ? C GLU 45 CD  
15 1 Y 1 C GLU 594 ? OE1 ? C GLU 45 OE1 
16 1 Y 1 C GLU 594 ? OE2 ? C GLU 45 OE2 
17 1 Y 1 C LYS 598 ? CD  ? C LYS 49 CD  
18 1 Y 1 C LYS 598 ? CE  ? C LYS 49 CE  
19 1 Y 1 C LYS 598 ? NZ  ? C LYS 49 NZ  
20 1 Y 1 D LYS 593 ? CG  ? D LYS 44 CG  
21 1 Y 1 D LYS 593 ? CD  ? D LYS 44 CD  
22 1 Y 1 D LYS 593 ? CE  ? D LYS 44 CE  
23 1 Y 1 D LYS 593 ? NZ  ? D LYS 44 NZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? '(1.10.1_2155: ???)' 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .                    2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .                    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .                    4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9KO8 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     54.562 
_cell.length_a_esd                 ? 
_cell.length_b                     166.946 
_cell.length_b_esd                 ? 
_cell.length_c                     39.108 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9KO8 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                18 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9KO8 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.18 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          43.53 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
'0.1 M sodium citrate/citric acid (pH 5.5), 20% (w/v) polyethylene glycol 4000, and 20% (v/v) isopropanol' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     93 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-12-02 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.987 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PAL/PLS BEAMLINE 11C' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.987 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   11C 
_diffrn_source.pdbx_synchrotron_site       PAL/PLS 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9KO8 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.8 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     9356 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           93.6 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                4.6 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          10.3 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                0.117 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.80 
_reflns_shell.d_res_low                                     2.85 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             371 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               0.263 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9KO8 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            3.000 
_refine.ls_d_res_low                             45.671 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     7239 
_refine.ls_number_reflns_R_free                  723 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    94.52 
_refine.ls_percent_reflns_R_free                 9.99 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2465 
_refine.ls_R_factor_R_free                       0.2914 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2412 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.46 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      9KNS 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 29.79 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.41 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       3.000 
_refine_hist.d_res_low                        45.671 
_refine_hist.number_atoms_solvent             27 
_refine_hist.number_atoms_total               2172 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2145 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.010  ? 2167 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.201  ? 2892 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 20.248 ? 1374 ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.056  ? 315  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.007  ? 372  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 3.0001 3.2317 . . 132 1203 90.00 . . . . 0.2491 . . . . . . . . . . . 0.3233 
'X-RAY DIFFRACTION' 3.2317 3.5568 . . 143 1293 96.00 . . . . 0.2457 . . . . . . . . . . . 0.3193 
'X-RAY DIFFRACTION' 3.5568 4.0712 . . 144 1286 96.00 . . . . 0.2180 . . . . . . . . . . . 0.2877 
'X-RAY DIFFRACTION' 4.0712 5.1281 . . 147 1312 95.00 . . . . 0.2250 . . . . . . . . . . . 0.2937 
'X-RAY DIFFRACTION' 5.1281 45.671 . . 157 1422 96.00 . . . . 0.2648 . . . . . . . . . . . 0.2671 
# 
_struct.entry_id                     9KO8 
_struct.title                        'Crystal structure of Hook3(553-624) bound to KIF1C(714-809)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9KO8 
_struct_keywords.text            'Hook3, KIF1C, TRANSPORT PROTEIN' 
_struct_keywords.pdbx_keywords   'TRANSPORT PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 3 ? 
F N N 3 ? 
G N N 3 ? 
H N N 3 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP KIF1C_HUMAN O43896 ? 1 
;PSSGKRRAPRRVYQIPQRRRLQGKDPRWATMADLKMQAVKEICYEVALADFRHGRAEIEALAALKMRELCRTYGKPDGPG
DAWRAVARDVWDTVGE
;
714 
2 UNP HOOK3_HUMAN Q86VS8 ? 2 EKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQ                            
553 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9KO8 A 4 ? 99 ? O43896 714 ? 809 ? 714 809 
2 1 9KO8 B 4 ? 99 ? O43896 714 ? 809 ? 714 809 
3 2 9KO8 C 4 ? 75 ? Q86VS8 553 ? 624 ? 553 624 
4 2 9KO8 D 4 ? 75 ? Q86VS8 553 ? 624 ? 553 624 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9KO8 GLY A 1 ? UNP O43896 ? ? 'expression tag' 711 1  
1 9KO8 HIS A 2 ? UNP O43896 ? ? 'expression tag' 712 2  
1 9KO8 MET A 3 ? UNP O43896 ? ? 'expression tag' 713 3  
2 9KO8 GLY B 1 ? UNP O43896 ? ? 'expression tag' 711 4  
2 9KO8 HIS B 2 ? UNP O43896 ? ? 'expression tag' 712 5  
2 9KO8 MET B 3 ? UNP O43896 ? ? 'expression tag' 713 6  
3 9KO8 GLY C 1 ? UNP Q86VS8 ? ? 'expression tag' 550 7  
3 9KO8 HIS C 2 ? UNP Q86VS8 ? ? 'expression tag' 551 8  
3 9KO8 MET C 3 ? UNP Q86VS8 ? ? 'expression tag' 552 9  
4 9KO8 GLY D 1 ? UNP Q86VS8 ? ? 'expression tag' 550 10 
4 9KO8 HIS D 2 ? UNP Q86VS8 ? ? 'expression tag' 551 11 
4 9KO8 MET D 3 ? UNP Q86VS8 ? ? 'expression tag' 552 12 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   tetrameric 
_pdbx_struct_assembly.oligomeric_count     4 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H 
# 
loop_
_pdbx_struct_assembly_auth_evidence.id 
_pdbx_struct_assembly_auth_evidence.assembly_id 
_pdbx_struct_assembly_auth_evidence.experimental_support 
_pdbx_struct_assembly_auth_evidence.details 
1 1 'native gel electrophoresis'       ? 
2 1 'isothermal titration calorimetry' ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 THR A 33 ? LEU A 51 ? THR A 743 LEU A 761 1 ? 19 
HELX_P HELX_P2 AA2 GLY A 57 ? ARG A 74 ? GLY A 767 ARG A 784 1 ? 18 
HELX_P HELX_P3 AA3 ASP A 84 ? ASP A 95 ? ASP A 794 ASP A 805 1 ? 12 
HELX_P HELX_P4 AA4 THR B 33 ? ALA B 52 ? THR B 743 ALA B 762 1 ? 20 
HELX_P HELX_P5 AA5 GLY B 57 ? TYR B 76 ? GLY B 767 TYR B 786 1 ? 20 
HELX_P HELX_P6 AA6 ASP B 84 ? GLY B 98 ? ASP B 794 GLY B 808 1 ? 15 
HELX_P HELX_P7 AA7 GLU C 4  ? LEU C 69 ? GLU C 553 LEU C 618 1 ? 66 
HELX_P HELX_P8 AA8 GLU D 4  ? LEU D 69 ? GLU D 553 LEU D 618 1 ? 66 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_pdbx_entry_details.entry_id                   9KO8 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 THR A 785 ? ? -91.75  -62.83  
2 1 ASP A 805 ? ? -63.15  1.59    
3 1 VAL A 807 ? ? -105.33 79.71   
4 1 THR B 743 ? ? -68.69  -172.09 
5 1 ALA B 762 ? ? -71.81  20.24   
6 1 LEU C 618 ? ? -82.44  37.20   
7 1 ASP D 619 ? ? -39.29  122.46  
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 711 ? A GLY 1  
2  1 Y 1 A HIS 712 ? A HIS 2  
3  1 Y 1 A MET 713 ? A MET 3  
4  1 Y 1 A PRO 714 ? A PRO 4  
5  1 Y 1 A SER 715 ? A SER 5  
6  1 Y 1 A SER 716 ? A SER 6  
7  1 Y 1 A GLY 717 ? A GLY 7  
8  1 Y 1 A LYS 718 ? A LYS 8  
9  1 Y 1 A ARG 719 ? A ARG 9  
10 1 Y 1 A ARG 720 ? A ARG 10 
11 1 Y 1 A ALA 721 ? A ALA 11 
12 1 Y 1 A PRO 722 ? A PRO 12 
13 1 Y 1 A ARG 723 ? A ARG 13 
14 1 Y 1 A ARG 724 ? A ARG 14 
15 1 Y 1 A VAL 725 ? A VAL 15 
16 1 Y 1 A TYR 726 ? A TYR 16 
17 1 Y 1 A GLN 727 ? A GLN 17 
18 1 Y 1 A ILE 728 ? A ILE 18 
19 1 Y 1 A PRO 729 ? A PRO 19 
20 1 Y 1 A GLN 730 ? A GLN 20 
21 1 Y 1 A ARG 731 ? A ARG 21 
22 1 Y 1 A ARG 732 ? A ARG 22 
23 1 Y 1 A ARG 733 ? A ARG 23 
24 1 Y 1 A LEU 734 ? A LEU 24 
25 1 Y 1 A GLN 735 ? A GLN 25 
26 1 Y 1 A GLY 736 ? A GLY 26 
27 1 Y 1 A LYS 737 ? A LYS 27 
28 1 Y 1 A ASP 738 ? A ASP 28 
29 1 Y 1 A PRO 739 ? A PRO 29 
30 1 Y 1 A ARG 740 ? A ARG 30 
31 1 Y 1 A TRP 741 ? A TRP 31 
32 1 Y 1 A GLY 787 ? A GLY 77 
33 1 Y 1 A LYS 788 ? A LYS 78 
34 1 Y 1 A PRO 789 ? A PRO 79 
35 1 Y 1 A ASP 790 ? A ASP 80 
36 1 Y 1 A GLY 791 ? A GLY 81 
37 1 Y 1 A PRO 792 ? A PRO 82 
38 1 Y 1 A GLU 809 ? A GLU 99 
39 1 Y 1 B GLY 711 ? B GLY 1  
40 1 Y 1 B HIS 712 ? B HIS 2  
41 1 Y 1 B MET 713 ? B MET 3  
42 1 Y 1 B PRO 714 ? B PRO 4  
43 1 Y 1 B SER 715 ? B SER 5  
44 1 Y 1 B SER 716 ? B SER 6  
45 1 Y 1 B GLY 717 ? B GLY 7  
46 1 Y 1 B LYS 718 ? B LYS 8  
47 1 Y 1 B ARG 719 ? B ARG 9  
48 1 Y 1 B ARG 720 ? B ARG 10 
49 1 Y 1 B ALA 721 ? B ALA 11 
50 1 Y 1 B PRO 722 ? B PRO 12 
51 1 Y 1 B ARG 723 ? B ARG 13 
52 1 Y 1 B ARG 724 ? B ARG 14 
53 1 Y 1 B VAL 725 ? B VAL 15 
54 1 Y 1 B TYR 726 ? B TYR 16 
55 1 Y 1 B GLN 727 ? B GLN 17 
56 1 Y 1 B ILE 728 ? B ILE 18 
57 1 Y 1 B PRO 729 ? B PRO 19 
58 1 Y 1 B GLN 730 ? B GLN 20 
59 1 Y 1 B ARG 731 ? B ARG 21 
60 1 Y 1 B ARG 732 ? B ARG 22 
61 1 Y 1 B ARG 733 ? B ARG 23 
62 1 Y 1 B LEU 734 ? B LEU 24 
63 1 Y 1 B GLN 735 ? B GLN 25 
64 1 Y 1 B GLY 736 ? B GLY 26 
65 1 Y 1 B LYS 737 ? B LYS 27 
66 1 Y 1 B ASP 738 ? B ASP 28 
67 1 Y 1 B PRO 739 ? B PRO 29 
68 1 Y 1 B ARG 740 ? B ARG 30 
69 1 Y 1 B TRP 741 ? B TRP 31 
70 1 Y 1 B GLY 787 ? B GLY 77 
71 1 Y 1 B LYS 788 ? B LYS 78 
72 1 Y 1 B PRO 789 ? B PRO 79 
73 1 Y 1 B ASP 790 ? B ASP 80 
74 1 Y 1 B GLY 791 ? B GLY 81 
75 1 Y 1 B PRO 792 ? B PRO 82 
76 1 Y 1 B GLU 809 ? B GLU 99 
77 1 Y 1 C GLY 550 ? C GLY 1  
78 1 Y 1 C HIS 551 ? C HIS 2  
79 1 Y 1 C ASN 623 ? C ASN 74 
80 1 Y 1 C GLN 624 ? C GLN 75 
81 1 Y 1 D GLY 550 ? D GLY 1  
82 1 Y 1 D HIS 551 ? D HIS 2  
83 1 Y 1 D ASN 623 ? D ASN 74 
84 1 Y 1 D GLN 624 ? D GLN 75 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Research Foundation (NRF, Korea)' 'Korea, Republic Of' KGM9952421   1 
'Other government'                          'Korea, Republic Of' CRC22021-700 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   9KNS 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9KO8 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.018328 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.005990 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.025570 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ALA A 1 32 ? -1.989  9.448   -14.436 1.00 42.79 ? 742 ALA A N   1 
ATOM   2    C CA  . ALA A 1 32 ? -0.653  10.043  -14.365 1.00 40.09 ? 742 ALA A CA  1 
ATOM   3    C C   . ALA A 1 32 ? -0.060  10.307  -15.757 1.00 37.29 ? 742 ALA A C   1 
ATOM   4    O O   . ALA A 1 32 ? 1.158   10.222  -15.936 1.00 42.46 ? 742 ALA A O   1 
ATOM   5    C CB  . ALA A 1 32 ? 0.301   9.150   -13.547 1.00 39.89 ? 742 ALA A CB  1 
ATOM   6    N N   . THR A 1 33 ? -0.910  10.618  -16.738 1.00 32.95 ? 743 THR A N   1 
ATOM   7    C CA  . THR A 1 33 ? -0.411  11.132  -18.006 1.00 34.86 ? 743 THR A CA  1 
ATOM   8    C C   . THR A 1 33 ? 0.260   12.481  -17.802 1.00 43.18 ? 743 THR A C   1 
ATOM   9    O O   . THR A 1 33 ? -0.205  13.322  -17.020 1.00 47.43 ? 743 THR A O   1 
ATOM   10   C CB  . THR A 1 33 ? -1.547  11.288  -19.016 1.00 41.72 ? 743 THR A CB  1 
ATOM   11   O OG1 . THR A 1 33 ? -2.737  11.719  -18.335 1.00 45.77 ? 743 THR A OG1 1 
ATOM   12   C CG2 . THR A 1 33 ? -1.812  9.979   -19.746 1.00 50.22 ? 743 THR A CG2 1 
ATOM   13   N N   . MET A 1 34 ? 1.357   12.702  -18.524 1.00 44.30 ? 744 MET A N   1 
ATOM   14   C CA  . MET A 1 34 ? 2.003   14.007  -18.476 1.00 39.67 ? 744 MET A CA  1 
ATOM   15   C C   . MET A 1 34 ? 1.045   15.151  -18.766 1.00 36.03 ? 744 MET A C   1 
ATOM   16   O O   . MET A 1 34 ? 1.163   16.194  -18.120 1.00 37.77 ? 744 MET A O   1 
ATOM   17   C CB  . MET A 1 34 ? 3.184   14.038  -19.442 1.00 40.28 ? 744 MET A CB  1 
ATOM   18   C CG  . MET A 1 34 ? 4.421   13.299  -18.930 1.00 35.56 ? 744 MET A CG  1 
ATOM   19   S SD  . MET A 1 34 ? 5.179   14.033  -17.443 1.00 41.77 ? 744 MET A SD  1 
ATOM   20   C CE  . MET A 1 34 ? 4.917   15.781  -17.709 1.00 39.12 ? 744 MET A CE  1 
ATOM   21   N N   . ALA A 1 35 ? 0.082   14.969  -19.682 1.00 35.28 ? 745 ALA A N   1 
ATOM   22   C CA  . ALA A 1 35 ? -0.830  16.063  -20.031 1.00 40.71 ? 745 ALA A CA  1 
ATOM   23   C C   . ALA A 1 35 ? -1.564  16.605  -18.809 1.00 40.93 ? 745 ALA A C   1 
ATOM   24   O O   . ALA A 1 35 ? -1.951  17.783  -18.800 1.00 41.99 ? 745 ALA A O   1 
ATOM   25   C CB  . ALA A 1 35 ? -1.836  15.620  -21.104 1.00 36.01 ? 745 ALA A CB  1 
ATOM   26   N N   . ASP A 1 36 ? -1.744  15.789  -17.764 1.00 35.84 ? 746 ASP A N   1 
ATOM   27   C CA  . ASP A 1 36 ? -2.360  16.267  -16.537 1.00 38.83 ? 746 ASP A CA  1 
ATOM   28   C C   . ASP A 1 36 ? -1.371  16.612  -15.438 1.00 34.21 ? 746 ASP A C   1 
ATOM   29   O O   . ASP A 1 36 ? -1.708  17.408  -14.557 1.00 31.49 ? 746 ASP A O   1 
ATOM   30   C CB  . ASP A 1 36 ? -3.369  15.251  -15.992 1.00 48.84 ? 746 ASP A CB  1 
ATOM   31   C CG  . ASP A 1 36 ? -4.403  14.876  -17.003 1.00 47.21 ? 746 ASP A CG  1 
ATOM   32   O OD1 . ASP A 1 36 ? -4.890  15.801  -17.709 1.00 49.95 ? 746 ASP A OD1 1 
ATOM   33   O OD2 . ASP A 1 36 ? -4.748  13.678  -17.054 1.00 44.88 ? 746 ASP A OD2 1 
ATOM   34   N N   . LEU A 1 37 ? -0.180  16.017  -15.440 1.00 33.17 ? 747 LEU A N   1 
ATOM   35   C CA  . LEU A 1 37 ? 0.889   16.560  -14.607 1.00 34.32 ? 747 LEU A CA  1 
ATOM   36   C C   . LEU A 1 37 ? 1.162   18.000  -14.996 1.00 33.12 ? 747 LEU A C   1 
ATOM   37   O O   . LEU A 1 37 ? 1.239   18.890  -14.139 1.00 31.78 ? 747 LEU A O   1 
ATOM   38   C CB  . LEU A 1 37 ? 2.152   15.707  -14.749 1.00 42.94 ? 747 LEU A CB  1 
ATOM   39   C CG  . LEU A 1 37 ? 2.152   14.347  -14.032 1.00 40.40 ? 747 LEU A CG  1 
ATOM   40   C CD1 . LEU A 1 37 ? 3.520   13.708  -14.109 1.00 37.90 ? 747 LEU A CD1 1 
ATOM   41   C CD2 . LEU A 1 37 ? 1.775   14.547  -12.567 1.00 37.24 ? 747 LEU A CD2 1 
ATOM   42   N N   . LYS A 1 38 ? 1.301   18.244  -16.297 1.00 38.35 ? 748 LYS A N   1 
ATOM   43   C CA  . LYS A 1 38 ? 1.393   19.602  -16.801 1.00 27.99 ? 748 LYS A CA  1 
ATOM   44   C C   . LYS A 1 38 ? 0.184   20.400  -16.360 1.00 26.05 ? 748 LYS A C   1 
ATOM   45   O O   . LYS A 1 38 ? 0.335   21.405  -15.666 1.00 34.22 ? 748 LYS A O   1 
ATOM   46   C CB  . LYS A 1 38 ? 1.519   19.589  -18.325 1.00 34.30 ? 748 LYS A CB  1 
ATOM   47   C CG  . LYS A 1 38 ? 2.847   19.033  -18.862 1.00 35.22 ? 748 LYS A CG  1 
ATOM   48   C CD  . LYS A 1 38 ? 3.021   19.393  -20.340 1.00 36.38 ? 748 LYS A CD  1 
ATOM   49   C CE  . LYS A 1 38 ? 1.816   18.990  -21.169 1.00 31.99 ? 748 LYS A CE  1 
ATOM   50   N NZ  . LYS A 1 38 ? 2.093   19.054  -22.628 1.00 32.43 ? 748 LYS A NZ  1 
ATOM   51   N N   . MET A 1 39 ? -1.030  19.950  -16.713 1.00 26.57 ? 749 MET A N   1 
ATOM   52   C CA  . MET A 1 39 ? -2.244  20.657  -16.302 1.00 24.36 ? 749 MET A CA  1 
ATOM   53   C C   . MET A 1 39 ? -2.264  20.969  -14.813 1.00 25.88 ? 749 MET A C   1 
ATOM   54   O O   . MET A 1 39 ? -2.770  22.019  -14.406 1.00 26.73 ? 749 MET A O   1 
ATOM   55   C CB  . MET A 1 39 ? -3.485  19.859  -16.648 1.00 28.97 ? 749 MET A CB  1 
ATOM   56   C CG  . MET A 1 39 ? -4.788  20.623  -16.436 1.00 31.04 ? 749 MET A CG  1 
ATOM   57   S SD  . MET A 1 39 ? -5.491  21.220  -17.993 1.00 50.95 ? 749 MET A SD  1 
ATOM   58   C CE  . MET A 1 39 ? -7.238  21.421  -17.531 1.00 42.13 ? 749 MET A CE  1 
ATOM   59   N N   . GLN A 1 40 ? -1.735  20.091  -13.971 1.00 28.62 ? 750 GLN A N   1 
ATOM   60   C CA  . GLN A 1 40 ? -1.725  20.444  -12.558 1.00 28.77 ? 750 GLN A CA  1 
ATOM   61   C C   . GLN A 1 40 ? -0.742  21.573  -12.282 1.00 26.38 ? 750 GLN A C   1 
ATOM   62   O O   . GLN A 1 40 ? -1.086  22.530  -11.596 1.00 28.19 ? 750 GLN A O   1 
ATOM   63   C CB  . GLN A 1 40 ? -1.409  19.248  -11.667 1.00 28.68 ? 750 GLN A CB  1 
ATOM   64   C CG  . GLN A 1 40 ? -1.451  19.650  -10.189 1.00 29.71 ? 750 GLN A CG  1 
ATOM   65   C CD  . GLN A 1 40 ? -2.884  19.789  -9.649  1.00 30.64 ? 750 GLN A CD  1 
ATOM   66   O OE1 . GLN A 1 40 ? -3.859  19.670  -10.401 1.00 31.29 ? 750 GLN A OE1 1 
ATOM   67   N NE2 . GLN A 1 40 ? -3.012  20.054  -8.352  1.00 26.20 ? 750 GLN A NE2 1 
ATOM   68   N N   . ALA A 1 41 ? 0.483   21.472  -12.785 1.00 26.40 ? 751 ALA A N   1 
ATOM   69   C CA  . ALA A 1 41 ? 1.421   22.576  -12.611 1.00 28.55 ? 751 ALA A CA  1 
ATOM   70   C C   . ALA A 1 41 ? 0.862   23.873  -13.168 1.00 28.28 ? 751 ALA A C   1 
ATOM   71   O O   . ALA A 1 41 ? 1.109   24.950  -12.608 1.00 28.96 ? 751 ALA A O   1 
ATOM   72   C CB  . ALA A 1 41 ? 2.750   22.264  -13.284 1.00 31.94 ? 751 ALA A CB  1 
ATOM   73   N N   . VAL A 1 42 ? 0.108   23.815  -14.258 1.00 26.00 ? 752 VAL A N   1 
ATOM   74   C CA  . VAL A 1 42 ? -0.475  25.055  -14.750 1.00 26.74 ? 752 VAL A CA  1 
ATOM   75   C C   . VAL A 1 42 ? -1.380  25.642  -13.673 1.00 23.78 ? 752 VAL A C   1 
ATOM   76   O O   . VAL A 1 42 ? -1.118  26.723  -13.147 1.00 21.84 ? 752 VAL A O   1 
ATOM   77   C CB  . VAL A 1 42 ? -1.197  24.826  -16.091 1.00 22.72 ? 752 VAL A CB  1 
ATOM   78   C CG1 . VAL A 1 42 ? -2.180  25.957  -16.386 1.00 24.91 ? 752 VAL A CG1 1 
ATOM   79   C CG2 . VAL A 1 42 ? -0.183  24.682  -17.196 1.00 21.70 ? 752 VAL A CG2 1 
ATOM   80   N N   . LYS A 1 43 ? -2.383  24.869  -13.243 1.00 27.80 ? 753 LYS A N   1 
ATOM   81   C CA  . LYS A 1 43 ? -3.271  25.271  -12.147 1.00 27.66 ? 753 LYS A CA  1 
ATOM   82   C C   . LYS A 1 43 ? -2.518  25.708  -10.895 1.00 22.72 ? 753 LYS A C   1 
ATOM   83   O O   . LYS A 1 43 ? -2.894  26.698  -10.272 1.00 22.61 ? 753 LYS A O   1 
ATOM   84   C CB  . LYS A 1 43 ? -4.221  24.121  -11.788 1.00 24.68 ? 753 LYS A CB  1 
ATOM   85   C CG  . LYS A 1 43 ? -5.171  23.776  -12.888 1.00 24.91 ? 753 LYS A CG  1 
ATOM   86   C CD  . LYS A 1 43 ? -5.873  22.456  -12.682 1.00 34.45 ? 753 LYS A CD  1 
ATOM   87   C CE  . LYS A 1 43 ? -6.837  22.207  -13.859 1.00 36.14 ? 753 LYS A CE  1 
ATOM   88   N NZ  . LYS A 1 43 ? -7.614  20.925  -13.815 1.00 52.27 ? 753 LYS A NZ  1 
ATOM   89   N N   . GLU A 1 44 ? -1.492  24.983  -10.485 1.00 24.07 ? 754 GLU A N   1 
ATOM   90   C CA  . GLU A 1 44 ? -0.839  25.326  -9.234  1.00 26.30 ? 754 GLU A CA  1 
ATOM   91   C C   . GLU A 1 44 ? 0.051   26.554  -9.359  1.00 26.20 ? 754 GLU A C   1 
ATOM   92   O O   . GLU A 1 44 ? 0.427   27.143  -8.341  1.00 27.99 ? 754 GLU A O   1 
ATOM   93   C CB  . GLU A 1 44 ? -0.012  24.145  -8.724  1.00 32.06 ? 754 GLU A CB  1 
ATOM   94   C CG  . GLU A 1 44 ? -0.705  23.286  -7.684  1.00 34.09 ? 754 GLU A CG  1 
ATOM   95   C CD  . GLU A 1 44 ? -0.005  21.946  -7.444  1.00 40.41 ? 754 GLU A CD  1 
ATOM   96   O OE1 . GLU A 1 44 ? -0.709  20.918  -7.420  1.00 44.73 ? 754 GLU A OE1 1 
ATOM   97   O OE2 . GLU A 1 44 ? 1.235   21.905  -7.288  1.00 45.97 ? 754 GLU A OE2 1 
ATOM   98   N N   . ILE A 1 45 ? 0.417   26.943  -10.572 1.00 26.98 ? 755 ILE A N   1 
ATOM   99   C CA  . ILE A 1 45 ? 1.135   28.201  -10.749 1.00 31.24 ? 755 ILE A CA  1 
ATOM   100  C C   . ILE A 1 45 ? 0.167   29.378  -10.769 1.00 24.52 ? 755 ILE A C   1 
ATOM   101  O O   . ILE A 1 45 ? 0.358   30.362  -10.056 1.00 29.48 ? 755 ILE A O   1 
ATOM   102  C CB  . ILE A 1 45 ? 1.983   28.169  -12.040 1.00 31.10 ? 755 ILE A CB  1 
ATOM   103  C CG1 . ILE A 1 45 ? 3.104   27.138  -11.959 1.00 26.49 ? 755 ILE A CG1 1 
ATOM   104  C CG2 . ILE A 1 45 ? 2.622   29.537  -12.250 1.00 21.47 ? 755 ILE A CG2 1 
ATOM   105  C CD1 . ILE A 1 45 ? 3.886   27.027  -13.245 1.00 23.78 ? 755 ILE A CD1 1 
ATOM   106  N N   . CYS A 1 46 ? -0.873  29.292  -11.598 1.00 20.13 ? 756 CYS A N   1 
ATOM   107  C CA  . CYS A 1 46 ? -1.872  30.348  -11.676 1.00 23.69 ? 756 CYS A CA  1 
ATOM   108  C C   . CYS A 1 46 ? -2.336  30.788  -10.289 1.00 29.82 ? 756 CYS A C   1 
ATOM   109  O O   . CYS A 1 46 ? -2.182  31.961  -9.911  1.00 25.07 ? 756 CYS A O   1 
ATOM   110  C CB  . CYS A 1 46 ? -3.039  29.863  -12.532 1.00 23.86 ? 756 CYS A CB  1 
ATOM   111  S SG  . CYS A 1 46 ? -2.604  29.734  -14.315 1.00 28.45 ? 756 CYS A SG  1 
ATOM   112  N N   . TYR A 1 47 ? -2.886  29.840  -9.520  1.00 33.21 ? 757 TYR A N   1 
ATOM   113  C CA  . TYR A 1 47 ? -3.271  30.045  -8.120  1.00 26.14 ? 757 TYR A CA  1 
ATOM   114  C C   . TYR A 1 47 ? -2.249  30.915  -7.380  1.00 26.14 ? 757 TYR A C   1 
ATOM   115  O O   . TYR A 1 47 ? -2.590  31.945  -6.789  1.00 25.48 ? 757 TYR A O   1 
ATOM   116  C CB  . TYR A 1 47 ? -3.410  28.667  -7.444  1.00 23.47 ? 757 TYR A CB  1 
ATOM   117  C CG  . TYR A 1 47 ? -3.786  28.690  -5.974  1.00 23.15 ? 757 TYR A CG  1 
ATOM   118  C CD1 . TYR A 1 47 ? -2.831  28.554  -4.984  1.00 17.97 ? 757 TYR A CD1 1 
ATOM   119  C CD2 . TYR A 1 47 ? -5.117  28.801  -5.588  1.00 26.09 ? 757 TYR A CD2 1 
ATOM   120  C CE1 . TYR A 1 47 ? -3.182  28.576  -3.673  1.00 18.99 ? 757 TYR A CE1 1 
ATOM   121  C CE2 . TYR A 1 47 ? -5.476  28.813  -4.274  1.00 24.81 ? 757 TYR A CE2 1 
ATOM   122  C CZ  . TYR A 1 47 ? -4.505  28.701  -3.318  1.00 23.52 ? 757 TYR A CZ  1 
ATOM   123  O OH  . TYR A 1 47 ? -4.867  28.725  -1.989  1.00 28.78 ? 757 TYR A OH  1 
ATOM   124  N N   . GLU A 1 48 ? -0.974  30.518  -7.441  1.00 25.65 ? 758 GLU A N   1 
ATOM   125  C CA  . GLU A 1 48 ? 0.072   31.151  -6.649  1.00 27.84 ? 758 GLU A CA  1 
ATOM   126  C C   . GLU A 1 48 ? 0.315   32.603  -7.083  1.00 30.86 ? 758 GLU A C   1 
ATOM   127  O O   . GLU A 1 48 ? 0.455   33.502  -6.243  1.00 31.31 ? 758 GLU A O   1 
ATOM   128  C CB  . GLU A 1 48 ? 1.343   30.307  -6.781  1.00 30.93 ? 758 GLU A CB  1 
ATOM   129  C CG  . GLU A 1 48 ? 2.634   30.953  -6.338  1.00 38.72 ? 758 GLU A CG  1 
ATOM   130  C CD  . GLU A 1 48 ? 3.719   29.931  -6.018  1.00 50.03 ? 758 GLU A CD  1 
ATOM   131  O OE1 . GLU A 1 48 ? 4.693   30.319  -5.337  1.00 63.55 ? 758 GLU A OE1 1 
ATOM   132  O OE2 . GLU A 1 48 ? 3.618   28.760  -6.468  1.00 47.61 ? 758 GLU A OE2 1 
ATOM   133  N N   . VAL A 1 49 ? 0.361   32.843  -8.400  1.00 28.51 ? 759 VAL A N   1 
ATOM   134  C CA  . VAL A 1 49 ? 0.580   34.184  -8.944  1.00 29.35 ? 759 VAL A CA  1 
ATOM   135  C C   . VAL A 1 49 ? -0.578  35.115  -8.603  1.00 28.02 ? 759 VAL A C   1 
ATOM   136  O O   . VAL A 1 49 ? -0.375  36.299  -8.327  1.00 28.38 ? 759 VAL A O   1 
ATOM   137  C CB  . VAL A 1 49 ? 0.790   34.093  -10.466 1.00 31.40 ? 759 VAL A CB  1 
ATOM   138  C CG1 . VAL A 1 49 ? 0.714   35.492  -11.137 1.00 29.06 ? 759 VAL A CG1 1 
ATOM   139  C CG2 . VAL A 1 49 ? 2.098   33.355  -10.768 1.00 29.03 ? 759 VAL A CG2 1 
ATOM   140  N N   . ALA A 1 50 ? -1.808  34.606  -8.649  1.00 25.27 ? 760 ALA A N   1 
ATOM   141  C CA  . ALA A 1 50 ? -2.954  35.416  -8.272  1.00 21.78 ? 760 ALA A CA  1 
ATOM   142  C C   . ALA A 1 50 ? -2.885  35.804  -6.806  1.00 25.70 ? 760 ALA A C   1 
ATOM   143  O O   . ALA A 1 50 ? -2.998  36.983  -6.469  1.00 32.96 ? 760 ALA A O   1 
ATOM   144  C CB  . ALA A 1 50 ? -4.248  34.670  -8.573  1.00 21.44 ? 760 ALA A CB  1 
ATOM   145  N N   . LEU A 1 51 ? -2.670  34.840  -5.916  1.00 26.77 ? 761 LEU A N   1 
ATOM   146  C CA  . LEU A 1 51 ? -2.626  35.162  -4.495  1.00 27.76 ? 761 LEU A CA  1 
ATOM   147  C C   . LEU A 1 51 ? -1.342  35.879  -4.108  1.00 29.84 ? 761 LEU A C   1 
ATOM   148  O O   . LEU A 1 51 ? -1.158  36.201  -2.930  1.00 35.18 ? 761 LEU A O   1 
ATOM   149  C CB  . LEU A 1 51 ? -2.779  33.897  -3.654  1.00 30.60 ? 761 LEU A CB  1 
ATOM   150  C CG  . LEU A 1 51 ? -4.159  33.243  -3.703  1.00 30.88 ? 761 LEU A CG  1 
ATOM   151  C CD1 . LEU A 1 51 ? -4.308  32.175  -2.613  1.00 31.00 ? 761 LEU A CD1 1 
ATOM   152  C CD2 . LEU A 1 51 ? -5.264  34.288  -3.642  1.00 29.99 ? 761 LEU A CD2 1 
ATOM   153  N N   . ALA A 1 52 ? -0.436  36.090  -5.052  1.00 26.41 ? 762 ALA A N   1 
ATOM   154  C CA  . ALA A 1 52 ? 0.650   37.036  -4.884  1.00 31.75 ? 762 ALA A CA  1 
ATOM   155  C C   . ALA A 1 52 ? 0.369   38.341  -5.632  1.00 41.94 ? 762 ALA A C   1 
ATOM   156  O O   . ALA A 1 52 ? 1.277   39.167  -5.802  1.00 43.56 ? 762 ALA A O   1 
ATOM   157  C CB  . ALA A 1 52 ? 1.971   36.411  -5.335  1.00 34.46 ? 762 ALA A CB  1 
ATOM   158  N N   . ASP A 1 53 ? -0.882  38.537  -6.076  1.00 41.38 ? 763 ASP A N   1 
ATOM   159  C CA  . ASP A 1 53 ? -1.358  39.781  -6.694  1.00 35.10 ? 763 ASP A CA  1 
ATOM   160  C C   . ASP A 1 53 ? -0.689  40.017  -8.040  1.00 33.34 ? 763 ASP A C   1 
ATOM   161  O O   . ASP A 1 53 ? -0.242  41.116  -8.348  1.00 35.55 ? 763 ASP A O   1 
ATOM   162  C CB  . ASP A 1 53 ? -1.167  40.956  -5.742  1.00 33.81 ? 763 ASP A CB  1 
ATOM   163  C CG  . ASP A 1 53 ? -1.748  40.655  -4.384  1.00 36.70 ? 763 ASP A CG  1 
ATOM   164  O OD1 . ASP A 1 53 ? -2.775  39.957  -4.356  1.00 34.35 ? 763 ASP A OD1 1 
ATOM   165  O OD2 . ASP A 1 53 ? -1.162  41.030  -3.352  1.00 39.70 ? 763 ASP A OD2 1 
ATOM   166  N N   . PHE A 1 54 ? -0.618  38.951  -8.832  1.00 34.75 ? 764 PHE A N   1 
ATOM   167  C CA  . PHE A 1 54 ? -0.002  38.951  -10.153 1.00 34.01 ? 764 PHE A CA  1 
ATOM   168  C C   . PHE A 1 54 ? 1.328   39.690  -10.157 1.00 36.68 ? 764 PHE A C   1 
ATOM   169  O O   . PHE A 1 54 ? 1.688   40.360  -11.122 1.00 40.52 ? 764 PHE A O   1 
ATOM   170  C CB  . PHE A 1 54 ? -0.988  39.485  -11.172 1.00 29.01 ? 764 PHE A CB  1 
ATOM   171  C CG  . PHE A 1 54 ? -2.280  38.721  -11.162 1.00 26.32 ? 764 PHE A CG  1 
ATOM   172  C CD1 . PHE A 1 54 ? -2.393  37.506  -11.804 1.00 25.12 ? 764 PHE A CD1 1 
ATOM   173  C CD2 . PHE A 1 54 ? -3.367  39.192  -10.471 1.00 28.25 ? 764 PHE A CD2 1 
ATOM   174  C CE1 . PHE A 1 54 ? -3.578  36.798  -11.770 1.00 25.21 ? 764 PHE A CE1 1 
ATOM   175  C CE2 . PHE A 1 54 ? -4.565  38.492  -10.446 1.00 25.10 ? 764 PHE A CE2 1 
ATOM   176  C CZ  . PHE A 1 54 ? -4.670  37.299  -11.085 1.00 23.16 ? 764 PHE A CZ  1 
ATOM   177  N N   . ARG A 1 55 ? 2.068   39.521  -9.061  1.00 38.31 ? 765 ARG A N   1 
ATOM   178  C CA  . ARG A 1 55 ? 3.411   40.062  -8.903  1.00 45.87 ? 765 ARG A CA  1 
ATOM   179  C C   . ARG A 1 55 ? 4.418   39.424  -9.856  1.00 46.58 ? 765 ARG A C   1 
ATOM   180  O O   . ARG A 1 55 ? 5.421   40.056  -10.196 1.00 48.54 ? 765 ARG A O   1 
ATOM   181  C CB  . ARG A 1 55 ? 3.838   39.858  -7.437  1.00 46.33 ? 765 ARG A CB  1 
ATOM   182  C CG  . ARG A 1 55 ? 5.316   40.064  -7.074  1.00 53.70 ? 765 ARG A CG  1 
ATOM   183  C CD  . ARG A 1 55 ? 5.606   39.501  -5.667  1.00 52.07 ? 765 ARG A CD  1 
ATOM   184  N NE  . ARG A 1 55 ? 6.066   38.112  -5.660  1.00 53.33 ? 765 ARG A NE  1 
ATOM   185  C CZ  . ARG A 1 55 ? 7.219   37.695  -6.185  1.00 56.74 ? 765 ARG A CZ  1 
ATOM   186  N NH1 . ARG A 1 55 ? 8.065   38.567  -6.720  1.00 57.15 ? 765 ARG A NH1 1 
ATOM   187  N NH2 . ARG A 1 55 ? 7.550   36.408  -6.145  1.00 53.66 ? 765 ARG A NH2 1 
ATOM   188  N N   . HIS A 1 56 ? 4.181   38.193  -10.296 1.00 45.00 ? 766 HIS A N   1 
ATOM   189  C CA  . HIS A 1 56 ? 5.183   37.437  -11.032 1.00 40.24 ? 766 HIS A CA  1 
ATOM   190  C C   . HIS A 1 56 ? 5.178   37.788  -12.515 1.00 46.97 ? 766 HIS A C   1 
ATOM   191  O O   . HIS A 1 56 ? 4.106   37.893  -13.127 1.00 50.16 ? 766 HIS A O   1 
ATOM   192  C CB  . HIS A 1 56 ? 4.950   35.937  -10.861 1.00 48.58 ? 766 HIS A CB  1 
ATOM   193  C CG  . HIS A 1 56 ? 5.037   35.453  -9.447  1.00 50.40 ? 766 HIS A CG  1 
ATOM   194  N ND1 . HIS A 1 56 ? 4.331   36.029  -8.409  1.00 46.46 ? 766 HIS A ND1 1 
ATOM   195  C CD2 . HIS A 1 56 ? 5.720   34.414  -8.899  1.00 44.21 ? 766 HIS A CD2 1 
ATOM   196  C CE1 . HIS A 1 56 ? 4.596   35.386  -7.288  1.00 45.95 ? 766 HIS A CE1 1 
ATOM   197  N NE2 . HIS A 1 56 ? 5.436   34.398  -7.562  1.00 43.58 ? 766 HIS A NE2 1 
ATOM   198  N N   . GLY A 1 57 ? 6.379   37.968  -13.078 1.00 45.73 ? 767 GLY A N   1 
ATOM   199  C CA  . GLY A 1 57 ? 6.609   38.123  -14.498 1.00 40.08 ? 767 GLY A CA  1 
ATOM   200  C C   . GLY A 1 57 ? 7.030   36.802  -15.136 1.00 41.34 ? 767 GLY A C   1 
ATOM   201  O O   . GLY A 1 57 ? 7.108   35.769  -14.482 1.00 46.65 ? 767 GLY A O   1 
ATOM   202  N N   . ARG A 1 58 ? 7.321   36.855  -16.443 1.00 39.69 ? 768 ARG A N   1 
ATOM   203  C CA  . ARG A 1 58 ? 7.520   35.645  -17.246 1.00 38.62 ? 768 ARG A CA  1 
ATOM   204  C C   . ARG A 1 58 ? 8.685   34.779  -16.743 1.00 40.96 ? 768 ARG A C   1 
ATOM   205  O O   . ARG A 1 58 ? 8.518   33.591  -16.454 1.00 35.18 ? 768 ARG A O   1 
ATOM   206  C CB  . ARG A 1 58 ? 7.751   36.004  -18.720 1.00 40.59 ? 768 ARG A CB  1 
ATOM   207  C CG  . ARG A 1 58 ? 6.730   35.480  -19.708 1.00 49.53 ? 768 ARG A CG  1 
ATOM   208  C CD  . ARG A 1 58 ? 7.080   34.089  -20.275 1.00 51.43 ? 768 ARG A CD  1 
ATOM   209  N NE  . ARG A 1 58 ? 6.132   33.689  -21.309 1.00 58.61 ? 768 ARG A NE  1 
ATOM   210  C CZ  . ARG A 1 58 ? 6.101   32.482  -21.865 1.00 54.95 ? 768 ARG A CZ  1 
ATOM   211  N NH1 . ARG A 1 58 ? 6.919   31.533  -21.444 1.00 40.60 ? 768 ARG A NH1 1 
ATOM   212  N NH2 . ARG A 1 58 ? 5.227   32.207  -22.823 1.00 56.64 ? 768 ARG A NH2 1 
ATOM   213  N N   . ALA A 1 59 ? 9.892   35.361  -16.713 1.00 45.95 ? 769 ALA A N   1 
ATOM   214  C CA  . ALA A 1 59 ? 11.049  34.588  -16.262 1.00 43.12 ? 769 ALA A CA  1 
ATOM   215  C C   . ALA A 1 59 ? 10.748  33.927  -14.940 1.00 40.12 ? 769 ALA A C   1 
ATOM   216  O O   . ALA A 1 59 ? 11.049  32.738  -14.748 1.00 43.09 ? 769 ALA A O   1 
ATOM   217  C CB  . ALA A 1 59 ? 12.289  35.474  -16.144 1.00 38.31 ? 769 ALA A CB  1 
ATOM   218  N N   . GLU A 1 60 ? 10.120  34.665  -14.027 1.00 37.89 ? 770 GLU A N   1 
ATOM   219  C CA  . GLU A 1 60 ? 9.669   34.087  -12.770 1.00 41.18 ? 770 GLU A CA  1 
ATOM   220  C C   . GLU A 1 60 ? 8.765   32.884  -13.022 1.00 44.83 ? 770 GLU A C   1 
ATOM   221  O O   . GLU A 1 60 ? 8.931   31.827  -12.396 1.00 41.53 ? 770 GLU A O   1 
ATOM   222  C CB  . GLU A 1 60 ? 8.944   35.155  -11.956 1.00 46.55 ? 770 GLU A CB  1 
ATOM   223  C CG  . GLU A 1 60 ? 9.609   36.565  -12.081 1.00 51.30 ? 770 GLU A CG  1 
ATOM   224  C CD  . GLU A 1 60 ? 9.632   37.344  -10.773 1.00 48.26 ? 770 GLU A CD  1 
ATOM   225  O OE1 . GLU A 1 60 ? 10.744  37.522  -10.226 1.00 36.94 ? 770 GLU A OE1 1 
ATOM   226  O OE2 . GLU A 1 60 ? 8.551   37.764  -10.317 1.00 53.43 ? 770 GLU A OE2 1 
ATOM   227  N N   . ILE A 1 61 ? 7.830   33.025  -13.972 1.00 42.27 ? 771 ILE A N   1 
ATOM   228  C CA  . ILE A 1 61 ? 6.876   31.952  -14.258 1.00 37.11 ? 771 ILE A CA  1 
ATOM   229  C C   . ILE A 1 61 ? 7.575   30.763  -14.916 1.00 39.96 ? 771 ILE A C   1 
ATOM   230  O O   . ILE A 1 61 ? 7.293   29.605  -14.582 1.00 39.93 ? 771 ILE A O   1 
ATOM   231  C CB  . ILE A 1 61 ? 5.716   32.495  -15.111 1.00 30.84 ? 771 ILE A CB  1 
ATOM   232  C CG1 . ILE A 1 61 ? 4.832   33.403  -14.266 1.00 40.33 ? 771 ILE A CG1 1 
ATOM   233  C CG2 . ILE A 1 61 ? 4.879   31.396  -15.633 1.00 32.60 ? 771 ILE A CG2 1 
ATOM   234  C CD1 . ILE A 1 61 ? 3.933   34.374  -15.054 1.00 42.55 ? 771 ILE A CD1 1 
ATOM   235  N N   . GLU A 1 62 ? 8.498   31.014  -15.844 1.00 39.92 ? 772 GLU A N   1 
ATOM   236  C CA  . GLU A 1 62 ? 9.220   29.908  -16.467 1.00 39.45 ? 772 GLU A CA  1 
ATOM   237  C C   . GLU A 1 62 ? 10.024  29.130  -15.437 1.00 39.20 ? 772 GLU A C   1 
ATOM   238  O O   . GLU A 1 62 ? 10.089  27.902  -15.487 1.00 39.15 ? 772 GLU A O   1 
ATOM   239  C CB  . GLU A 1 62 ? 10.148  30.411  -17.567 1.00 43.35 ? 772 GLU A CB  1 
ATOM   240  C CG  . GLU A 1 62 ? 9.474   31.061  -18.744 1.00 39.43 ? 772 GLU A CG  1 
ATOM   241  C CD  . GLU A 1 62 ? 10.427  31.167  -19.892 1.00 42.63 ? 772 GLU A CD  1 
ATOM   242  O OE1 . GLU A 1 62 ? 9.980   31.458  -21.018 1.00 47.21 ? 772 GLU A OE1 1 
ATOM   243  O OE2 . GLU A 1 62 ? 11.641  30.967  -19.649 1.00 52.02 ? 772 GLU A OE2 1 
ATOM   244  N N   . ALA A 1 63 ? 10.664  29.841  -14.510 1.00 45.03 ? 773 ALA A N   1 
ATOM   245  C CA  . ALA A 1 63 ? 11.345  29.156  -13.415 1.00 48.24 ? 773 ALA A CA  1 
ATOM   246  C C   . ALA A 1 63 ? 10.341  28.415  -12.537 1.00 42.36 ? 773 ALA A C   1 
ATOM   247  O O   . ALA A 1 63 ? 10.532  27.243  -12.204 1.00 37.55 ? 773 ALA A O   1 
ATOM   248  C CB  . ALA A 1 63 ? 12.164  30.162  -12.597 1.00 48.13 ? 773 ALA A CB  1 
ATOM   249  N N   . LEU A 1 64 ? 9.249   29.080  -12.174 1.00 43.52 ? 774 LEU A N   1 
ATOM   250  C CA  . LEU A 1 64 ? 8.268   28.380  -11.364 1.00 43.60 ? 774 LEU A CA  1 
ATOM   251  C C   . LEU A 1 64 ? 7.531   27.304  -12.139 1.00 39.57 ? 774 LEU A C   1 
ATOM   252  O O   . LEU A 1 64 ? 6.751   26.567  -11.538 1.00 45.45 ? 774 LEU A O   1 
ATOM   253  C CB  . LEU A 1 64 ? 7.289   29.385  -10.748 1.00 44.86 ? 774 LEU A CB  1 
ATOM   254  C CG  . LEU A 1 64 ? 7.597   29.524  -9.244  1.00 53.14 ? 774 LEU A CG  1 
ATOM   255  C CD1 . LEU A 1 64 ? 6.886   30.702  -8.571  1.00 53.14 ? 774 LEU A CD1 1 
ATOM   256  C CD2 . LEU A 1 64 ? 7.299   28.217  -8.496  1.00 44.19 ? 774 LEU A CD2 1 
ATOM   257  N N   . ALA A 1 65 ? 7.759   27.175  -13.438 1.00 37.07 ? 775 ALA A N   1 
ATOM   258  C CA  . ALA A 1 65 ? 7.171   26.078  -14.185 1.00 36.84 ? 775 ALA A CA  1 
ATOM   259  C C   . ALA A 1 65 ? 8.056   24.840  -14.140 1.00 38.18 ? 775 ALA A C   1 
ATOM   260  O O   . ALA A 1 65 ? 7.568   23.744  -13.861 1.00 42.17 ? 775 ALA A O   1 
ATOM   261  C CB  . ALA A 1 65 ? 6.913   26.505  -15.630 1.00 38.07 ? 775 ALA A CB  1 
ATOM   262  N N   . ALA A 1 66 ? 9.354   25.011  -14.408 1.00 37.06 ? 776 ALA A N   1 
ATOM   263  C CA  . ALA A 1 66 ? 10.308  23.911  -14.313 1.00 40.41 ? 776 ALA A CA  1 
ATOM   264  C C   . ALA A 1 66 ? 10.295  23.281  -12.922 1.00 46.13 ? 776 ALA A C   1 
ATOM   265  O O   . ALA A 1 66 ? 10.093  22.066  -12.777 1.00 49.45 ? 776 ALA A O   1 
ATOM   266  C CB  . ALA A 1 66 ? 11.706  24.418  -14.657 1.00 38.85 ? 776 ALA A CB  1 
ATOM   267  N N   . LEU A 1 67 ? 10.510  24.097  -11.888 1.00 42.85 ? 777 LEU A N   1 
ATOM   268  C CA  . LEU A 1 67 ? 10.508  23.620  -10.507 1.00 43.33 ? 777 LEU A CA  1 
ATOM   269  C C   . LEU A 1 67 ? 9.223   22.879  -10.183 1.00 48.69 ? 777 LEU A C   1 
ATOM   270  O O   . LEU A 1 67 ? 9.241   21.803  -9.568  1.00 54.01 ? 777 LEU A O   1 
ATOM   271  C CB  . LEU A 1 67 ? 10.666  24.807  -9.563  1.00 54.02 ? 777 LEU A CB  1 
ATOM   272  C CG  . LEU A 1 67 ? 11.396  24.724  -8.222  1.00 65.80 ? 777 LEU A CG  1 
ATOM   273  C CD1 . LEU A 1 67 ? 11.804  26.143  -7.804  1.00 62.80 ? 777 LEU A CD1 1 
ATOM   274  C CD2 . LEU A 1 67 ? 10.548  24.052  -7.125  1.00 52.39 ? 777 LEU A CD2 1 
ATOM   275  N N   . LYS A 1 68 ? 8.087   23.474  -10.546 1.00 44.22 ? 778 LYS A N   1 
ATOM   276  C CA  . LYS A 1 68 ? 6.820   22.784  -10.357 1.00 46.40 ? 778 LYS A CA  1 
ATOM   277  C C   . LYS A 1 68 ? 6.811   21.471  -11.121 1.00 46.31 ? 778 LYS A C   1 
ATOM   278  O O   . LYS A 1 68 ? 6.291   20.467  -10.619 1.00 50.83 ? 778 LYS A O   1 
ATOM   279  C CB  . LYS A 1 68 ? 5.661   23.696  -10.782 1.00 44.41 ? 778 LYS A CB  1 
ATOM   280  C CG  . LYS A 1 68 ? 4.259   23.300  -10.272 1.00 40.25 ? 778 LYS A CG  1 
ATOM   281  C CD  . LYS A 1 68 ? 4.152   23.365  -8.731  1.00 49.97 ? 778 LYS A CD  1 
ATOM   282  C CE  . LYS A 1 68 ? 4.409   24.748  -8.105  1.00 43.23 ? 778 LYS A CE  1 
ATOM   283  N NZ  . LYS A 1 68 ? 4.511   24.630  -6.604  1.00 39.15 ? 778 LYS A NZ  1 
ATOM   284  N N   . MET A 1 69 ? 7.453   21.444  -12.296 1.00 43.03 ? 779 MET A N   1 
ATOM   285  C CA  . MET A 1 69 ? 7.470   20.259  -13.144 1.00 41.88 ? 779 MET A CA  1 
ATOM   286  C C   . MET A 1 69 ? 8.464   19.208  -12.648 1.00 48.78 ? 779 MET A C   1 
ATOM   287  O O   . MET A 1 69 ? 8.212   18.002  -12.768 1.00 50.80 ? 779 MET A O   1 
ATOM   288  C CB  . MET A 1 69 ? 7.782   20.654  -14.590 1.00 39.78 ? 779 MET A CB  1 
ATOM   289  C CG  . MET A 1 69 ? 6.906   19.947  -15.617 1.00 41.70 ? 779 MET A CG  1 
ATOM   290  S SD  . MET A 1 69 ? 5.139   20.137  -15.276 1.00 35.43 ? 779 MET A SD  1 
ATOM   291  C CE  . MET A 1 69 ? 4.541   18.508  -15.639 1.00 37.96 ? 779 MET A CE  1 
ATOM   292  N N   . ARG A 1 70 ? 9.605   19.626  -12.102 1.00 46.98 ? 780 ARG A N   1 
ATOM   293  C CA  . ARG A 1 70 ? 10.530  18.609  -11.610 1.00 50.83 ? 780 ARG A CA  1 
ATOM   294  C C   . ARG A 1 70 ? 10.090  18.055  -10.266 1.00 49.19 ? 780 ARG A C   1 
ATOM   295  O O   . ARG A 1 70 ? 10.380  16.899  -9.953  1.00 52.72 ? 780 ARG A O   1 
ATOM   296  C CB  . ARG A 1 70 ? 11.948  19.157  -11.520 1.00 46.17 ? 780 ARG A CB  1 
ATOM   297  C CG  . ARG A 1 70 ? 12.572  19.358  -12.882 1.00 56.35 ? 780 ARG A CG  1 
ATOM   298  C CD  . ARG A 1 70 ? 14.005  19.789  -12.770 1.00 58.17 ? 780 ARG A CD  1 
ATOM   299  N NE  . ARG A 1 70 ? 14.089  21.088  -12.122 1.00 65.11 ? 780 ARG A NE  1 
ATOM   300  C CZ  . ARG A 1 70 ? 14.279  22.230  -12.772 1.00 64.38 ? 780 ARG A CZ  1 
ATOM   301  N NH1 . ARG A 1 70 ? 14.393  22.226  -14.091 1.00 72.73 ? 780 ARG A NH1 1 
ATOM   302  N NH2 . ARG A 1 70 ? 14.340  23.374  -12.106 1.00 64.74 ? 780 ARG A NH2 1 
ATOM   303  N N   . GLU A 1 71 ? 9.362   18.841  -9.474  1.00 48.34 ? 781 GLU A N   1 
ATOM   304  C CA  . GLU A 1 71 ? 8.861   18.294  -8.221  1.00 51.58 ? 781 GLU A CA  1 
ATOM   305  C C   . GLU A 1 71 ? 7.646   17.407  -8.458  1.00 48.25 ? 781 GLU A C   1 
ATOM   306  O O   . GLU A 1 71 ? 7.434   16.444  -7.717  1.00 54.14 ? 781 GLU A O   1 
ATOM   307  C CB  . GLU A 1 71 ? 8.514   19.413  -7.236  1.00 58.21 ? 781 GLU A CB  1 
ATOM   308  C CG  . GLU A 1 71 ? 7.617   18.923  -6.114  1.00 60.49 ? 781 GLU A CG  1 
ATOM   309  C CD  . GLU A 1 71 ? 6.195   19.472  -6.189  1.00 67.03 ? 781 GLU A CD  1 
ATOM   310  O OE1 . GLU A 1 71 ? 5.262   18.638  -6.105  1.00 60.27 ? 781 GLU A OE1 1 
ATOM   311  O OE2 . GLU A 1 71 ? 6.037   20.706  -6.279  1.00 64.66 ? 781 GLU A OE2 1 
ATOM   312  N N   . LEU A 1 72 ? 6.851   17.692  -9.492  1.00 46.49 ? 782 LEU A N   1 
ATOM   313  C CA  . LEU A 1 72 ? 5.712   16.819  -9.797  1.00 55.23 ? 782 LEU A CA  1 
ATOM   314  C C   . LEU A 1 72 ? 6.158   15.467  -10.348 1.00 54.34 ? 782 LEU A C   1 
ATOM   315  O O   . LEU A 1 72 ? 5.632   14.422  -9.942  1.00 47.60 ? 782 LEU A O   1 
ATOM   316  C CB  . LEU A 1 72 ? 4.748   17.514  -10.768 1.00 48.22 ? 782 LEU A CB  1 
ATOM   317  C CG  . LEU A 1 72 ? 3.798   18.479  -10.066 1.00 47.59 ? 782 LEU A CG  1 
ATOM   318  C CD1 . LEU A 1 72 ? 2.822   19.128  -11.028 1.00 39.68 ? 782 LEU A CD1 1 
ATOM   319  C CD2 . LEU A 1 72 ? 3.034   17.646  -9.042  1.00 51.74 ? 782 LEU A CD2 1 
ATOM   320  N N   . CYS A 1 73 ? 7.123   15.457  -11.268 1.00 53.94 ? 783 CYS A N   1 
ATOM   321  C CA  . CYS A 1 73 ? 7.641   14.185  -11.757 1.00 55.00 ? 783 CYS A CA  1 
ATOM   322  C C   . CYS A 1 73 ? 8.228   13.343  -10.620 1.00 52.59 ? 783 CYS A C   1 
ATOM   323  O O   . CYS A 1 73 ? 8.192   12.104  -10.685 1.00 47.45 ? 783 CYS A O   1 
ATOM   324  C CB  . CYS A 1 73 ? 8.677   14.434  -12.859 1.00 50.85 ? 783 CYS A CB  1 
ATOM   325  S SG  . CYS A 1 73 ? 8.033   14.298  -14.544 1.00 49.59 ? 783 CYS A SG  1 
ATOM   326  N N   . ARG A 1 74 ? 8.751   13.991  -9.571  1.00 48.70 ? 784 ARG A N   1 
ATOM   327  C CA  . ARG A 1 74 ? 9.198   13.289  -8.383  1.00 48.87 ? 784 ARG A CA  1 
ATOM   328  C C   . ARG A 1 74 ? 8.058   13.077  -7.383  1.00 53.87 ? 784 ARG A C   1 
ATOM   329  O O   . ARG A 1 74 ? 8.319   12.739  -6.224  1.00 53.70 ? 784 ARG A O   1 
ATOM   330  C CB  . ARG A 1 74 ? 10.356  14.046  -7.730  1.00 53.13 ? 784 ARG A CB  1 
ATOM   331  C CG  . ARG A 1 74 ? 11.394  13.140  -7.055  1.00 61.55 ? 784 ARG A CG  1 
ATOM   332  C CD  . ARG A 1 74 ? 12.521  12.742  -8.030  1.00 68.61 ? 784 ARG A CD  1 
ATOM   333  N NE  . ARG A 1 74 ? 12.986  11.386  -7.783  1.00 77.67 ? 784 ARG A NE  1 
ATOM   334  C CZ  . ARG A 1 74 ? 14.224  10.957  -8.041  1.00 79.59 ? 784 ARG A CZ  1 
ATOM   335  N NH1 . ARG A 1 74 ? 15.142  11.784  -8.532  1.00 78.11 ? 784 ARG A NH1 1 
ATOM   336  N NH2 . ARG A 1 74 ? 14.565  9.691   -7.811  1.00 79.43 ? 784 ARG A NH2 1 
ATOM   337  N N   . THR A 1 75 ? 6.806   13.300  -7.794  1.00 52.20 ? 785 THR A N   1 
ATOM   338  C CA  . THR A 1 75 ? 5.660   12.830  -7.015  1.00 58.90 ? 785 THR A CA  1 
ATOM   339  C C   . THR A 1 75 ? 5.234   11.440  -7.484  1.00 59.40 ? 785 THR A C   1 
ATOM   340  O O   . THR A 1 75 ? 5.307   10.469  -6.722  1.00 69.90 ? 785 THR A O   1 
ATOM   341  C CB  . THR A 1 75 ? 4.461   13.787  -7.125  1.00 64.84 ? 785 THR A CB  1 
ATOM   342  O OG1 . THR A 1 75 ? 4.886   15.153  -6.985  1.00 64.82 ? 785 THR A OG1 1 
ATOM   343  C CG2 . THR A 1 75 ? 3.409   13.450  -6.041  1.00 59.61 ? 785 THR A CG2 1 
ATOM   344  N N   . TYR A 1 76 ? 4.806   11.329  -8.738  1.00 52.03 ? 786 TYR A N   1 
ATOM   345  C CA  . TYR A 1 76 ? 4.254   10.084  -9.262  1.00 57.47 ? 786 TYR A CA  1 
ATOM   346  C C   . TYR A 1 76 ? 5.353   9.165   -9.802  1.00 56.73 ? 786 TYR A C   1 
ATOM   347  O O   . TYR A 1 76 ? 6.545   9.440   -9.638  1.00 56.38 ? 786 TYR A O   1 
ATOM   348  C CB  . TYR A 1 76 ? 3.219   10.379  -10.357 1.00 55.55 ? 786 TYR A CB  1 
ATOM   349  C CG  . TYR A 1 76 ? 2.024   11.194  -9.899  1.00 49.55 ? 786 TYR A CG  1 
ATOM   350  C CD1 . TYR A 1 76 ? 0.736   10.667  -9.950  1.00 47.70 ? 786 TYR A CD1 1 
ATOM   351  C CD2 . TYR A 1 76 ? 2.182   12.495  -9.424  1.00 54.80 ? 786 TYR A CD2 1 
ATOM   352  C CE1 . TYR A 1 76 ? -0.368  11.417  -9.534  1.00 54.19 ? 786 TYR A CE1 1 
ATOM   353  C CE2 . TYR A 1 76 ? 1.096   13.253  -9.001  1.00 55.59 ? 786 TYR A CE2 1 
ATOM   354  C CZ  . TYR A 1 76 ? -0.176  12.717  -9.060  1.00 62.16 ? 786 TYR A CZ  1 
ATOM   355  O OH  . TYR A 1 76 ? -1.237  13.499  -8.647  1.00 56.87 ? 786 TYR A OH  1 
ATOM   356  N N   . GLY A 1 83 ? 11.150  17.837  -18.610 1.00 36.81 ? 793 GLY A N   1 
ATOM   357  C CA  . GLY A 1 83 ? 12.220  18.334  -19.467 1.00 42.90 ? 793 GLY A CA  1 
ATOM   358  C C   . GLY A 1 83 ? 11.882  19.605  -20.242 1.00 39.15 ? 793 GLY A C   1 
ATOM   359  O O   . GLY A 1 83 ? 12.181  20.701  -19.793 1.00 42.44 ? 793 GLY A O   1 
ATOM   360  N N   . ASP A 1 84 ? 11.296  19.460  -21.429 1.00 34.52 ? 794 ASP A N   1 
ATOM   361  C CA  . ASP A 1 84 ? 10.619  20.553  -22.105 1.00 37.74 ? 794 ASP A CA  1 
ATOM   362  C C   . ASP A 1 84 ? 9.134   20.628  -21.736 1.00 41.95 ? 794 ASP A C   1 
ATOM   363  O O   . ASP A 1 84 ? 8.355   21.281  -22.443 1.00 42.86 ? 794 ASP A O   1 
ATOM   364  C CB  . ASP A 1 84 ? 10.803  20.428  -23.622 1.00 42.12 ? 794 ASP A CB  1 
ATOM   365  C CG  . ASP A 1 84 ? 12.073  21.153  -24.139 1.00 57.68 ? 794 ASP A CG  1 
ATOM   366  O OD1 . ASP A 1 84 ? 12.935  21.582  -23.323 1.00 52.21 ? 794 ASP A OD1 1 
ATOM   367  O OD2 . ASP A 1 84 ? 12.223  21.270  -25.384 1.00 60.44 ? 794 ASP A OD2 1 
ATOM   368  N N   . ALA A 1 85 ? 8.729   19.983  -20.635 1.00 38.88 ? 795 ALA A N   1 
ATOM   369  C CA  . ALA A 1 85 ? 7.332   20.055  -20.209 1.00 38.16 ? 795 ALA A CA  1 
ATOM   370  C C   . ALA A 1 85 ? 6.990   21.448  -19.701 1.00 42.74 ? 795 ALA A C   1 
ATOM   371  O O   . ALA A 1 85 ? 5.873   21.944  -19.916 1.00 45.17 ? 795 ALA A O   1 
ATOM   372  C CB  . ALA A 1 85 ? 7.041   19.014  -19.127 1.00 35.60 ? 795 ALA A CB  1 
ATOM   373  N N   . TRP A 1 86 ? 7.940   22.107  -19.043 1.00 38.82 ? 796 TRP A N   1 
ATOM   374  C CA  . TRP A 1 86 ? 7.646   23.408  -18.470 1.00 34.86 ? 796 TRP A CA  1 
ATOM   375  C C   . TRP A 1 86 ? 7.403   24.461  -19.537 1.00 37.00 ? 796 TRP A C   1 
ATOM   376  O O   . TRP A 1 86 ? 6.741   25.464  -19.258 1.00 41.90 ? 796 TRP A O   1 
ATOM   377  C CB  . TRP A 1 86 ? 8.784   23.851  -17.564 1.00 35.47 ? 796 TRP A CB  1 
ATOM   378  C CG  . TRP A 1 86 ? 10.057  23.905  -18.292 1.00 39.75 ? 796 TRP A CG  1 
ATOM   379  C CD1 . TRP A 1 86 ? 10.950  22.898  -18.440 1.00 43.23 ? 796 TRP A CD1 1 
ATOM   380  C CD2 . TRP A 1 86 ? 10.595  25.030  -19.006 1.00 46.32 ? 796 TRP A CD2 1 
ATOM   381  N NE1 . TRP A 1 86 ? 12.020  23.320  -19.195 1.00 43.85 ? 796 TRP A NE1 1 
ATOM   382  C CE2 . TRP A 1 86 ? 11.824  24.630  -19.552 1.00 46.33 ? 796 TRP A CE2 1 
ATOM   383  C CE3 . TRP A 1 86 ? 10.160  26.344  -19.221 1.00 43.70 ? 796 TRP A CE3 1 
ATOM   384  C CZ2 . TRP A 1 86 ? 12.622  25.488  -20.308 1.00 46.70 ? 796 TRP A CZ2 1 
ATOM   385  C CZ3 . TRP A 1 86 ? 10.958  27.194  -19.968 1.00 44.47 ? 796 TRP A CZ3 1 
ATOM   386  C CH2 . TRP A 1 86 ? 12.172  26.760  -20.506 1.00 44.72 ? 796 TRP A CH2 1 
ATOM   387  N N   . ARG A 1 87 ? 7.950   24.290  -20.748 1.00 37.93 ? 797 ARG A N   1 
ATOM   388  C CA  . ARG A 1 87 ? 7.738   25.303  -21.786 1.00 40.20 ? 797 ARG A CA  1 
ATOM   389  C C   . ARG A 1 87 ? 6.264   25.447  -22.129 1.00 36.83 ? 797 ARG A C   1 
ATOM   390  O O   . ARG A 1 87 ? 5.782   26.561  -22.370 1.00 32.62 ? 797 ARG A O   1 
ATOM   391  C CB  . ARG A 1 87 ? 8.519   24.967  -23.052 1.00 39.99 ? 797 ARG A CB  1 
ATOM   392  C CG  . ARG A 1 87 ? 9.946   24.615  -22.820 1.00 45.07 ? 797 ARG A CG  1 
ATOM   393  C CD  . ARG A 1 87 ? 10.705  24.691  -24.119 1.00 47.71 ? 797 ARG A CD  1 
ATOM   394  N NE  . ARG A 1 87 ? 12.124  24.536  -23.851 1.00 51.04 ? 797 ARG A NE  1 
ATOM   395  C CZ  . ARG A 1 87 ? 12.966  25.564  -23.769 1.00 50.06 ? 797 ARG A CZ  1 
ATOM   396  N NH1 . ARG A 1 87 ? 12.523  26.801  -23.953 1.00 46.56 ? 797 ARG A NH1 1 
ATOM   397  N NH2 . ARG A 1 87 ? 14.248  25.362  -23.502 1.00 54.02 ? 797 ARG A NH2 1 
ATOM   398  N N   . ALA A 1 88 ? 5.545   24.333  -22.178 1.00 30.72 ? 798 ALA A N   1 
ATOM   399  C CA  . ALA A 1 88 ? 4.139   24.365  -22.534 1.00 28.81 ? 798 ALA A CA  1 
ATOM   400  C C   . ALA A 1 88 ? 3.283   24.660  -21.337 1.00 28.85 ? 798 ALA A C   1 
ATOM   401  O O   . ALA A 1 88 ? 2.147   25.104  -21.503 1.00 28.19 ? 798 ALA A O   1 
ATOM   402  C CB  . ALA A 1 88 ? 3.698   23.033  -23.138 1.00 36.70 ? 798 ALA A CB  1 
ATOM   403  N N   . VAL A 1 89 ? 3.807   24.386  -20.146 1.00 30.56 ? 799 VAL A N   1 
ATOM   404  C CA  . VAL A 1 89 ? 3.176   24.814  -18.906 1.00 32.04 ? 799 VAL A CA  1 
ATOM   405  C C   . VAL A 1 89 ? 3.271   26.326  -18.751 1.00 34.71 ? 799 VAL A C   1 
ATOM   406  O O   . VAL A 1 89 ? 2.248   27.019  -18.671 1.00 33.41 ? 799 VAL A O   1 
ATOM   407  C CB  . VAL A 1 89 ? 3.830   24.078  -17.726 1.00 30.78 ? 799 VAL A CB  1 
ATOM   408  C CG1 . VAL A 1 89 ? 3.243   24.535  -16.409 1.00 28.76 ? 799 VAL A CG1 1 
ATOM   409  C CG2 . VAL A 1 89 ? 3.659   22.585  -17.919 1.00 34.06 ? 799 VAL A CG2 1 
ATOM   410  N N   . ALA A 1 90 ? 4.500   26.862  -18.731 1.00 35.96 ? 800 ALA A N   1 
ATOM   411  C CA  . ALA A 1 90 ? 4.685   28.303  -18.560 1.00 30.47 ? 800 ALA A CA  1 
ATOM   412  C C   . ALA A 1 90 ? 4.016   29.089  -19.680 1.00 29.43 ? 800 ALA A C   1 
ATOM   413  O O   . ALA A 1 90 ? 3.535   30.202  -19.453 1.00 29.84 ? 800 ALA A O   1 
ATOM   414  C CB  . ALA A 1 90 ? 6.170   28.643  -18.468 1.00 30.73 ? 800 ALA A CB  1 
ATOM   415  N N   . ARG A 1 91 ? 3.951   28.539  -20.887 1.00 29.45 ? 801 ARG A N   1 
ATOM   416  C CA  . ARG A 1 91 ? 3.232   29.267  -21.920 1.00 30.60 ? 801 ARG A CA  1 
ATOM   417  C C   . ARG A 1 91 ? 1.763   29.322  -21.590 1.00 28.64 ? 801 ARG A C   1 
ATOM   418  O O   . ARG A 1 91 ? 1.134   30.377  -21.681 1.00 34.71 ? 801 ARG A O   1 
ATOM   419  C CB  . ARG A 1 91 ? 3.414   28.653  -23.297 1.00 33.23 ? 801 ARG A CB  1 
ATOM   420  C CG  . ARG A 1 91 ? 2.559   29.446  -24.284 1.00 38.10 ? 801 ARG A CG  1 
ATOM   421  C CD  . ARG A 1 91 ? 2.260   28.722  -25.568 1.00 48.21 ? 801 ARG A CD  1 
ATOM   422  N NE  . ARG A 1 91 ? 1.919   27.340  -25.307 1.00 40.79 ? 801 ARG A NE  1 
ATOM   423  C CZ  . ARG A 1 91 ? 2.677   26.327  -25.696 1.00 43.95 ? 801 ARG A CZ  1 
ATOM   424  N NH1 . ARG A 1 91 ? 3.804   26.562  -26.375 1.00 46.48 ? 801 ARG A NH1 1 
ATOM   425  N NH2 . ARG A 1 91 ? 2.309   25.089  -25.402 1.00 41.62 ? 801 ARG A NH2 1 
ATOM   426  N N   . ASP A 1 92 ? 1.195   28.196  -21.202 1.00 30.09 ? 802 ASP A N   1 
ATOM   427  C CA  . ASP A 1 92 ? -0.202  28.195  -20.809 1.00 33.48 ? 802 ASP A CA  1 
ATOM   428  C C   . ASP A 1 92 ? -0.437  29.105  -19.610 1.00 33.32 ? 802 ASP A C   1 
ATOM   429  O O   . ASP A 1 92 ? -1.531  29.646  -19.450 1.00 34.44 ? 802 ASP A O   1 
ATOM   430  C CB  . ASP A 1 92 ? -0.650  26.758  -20.527 1.00 32.89 ? 802 ASP A CB  1 
ATOM   431  C CG  . ASP A 1 92 ? -0.781  25.918  -21.799 1.00 37.30 ? 802 ASP A CG  1 
ATOM   432  O OD1 . ASP A 1 92 ? -1.136  26.470  -22.867 1.00 40.37 ? 802 ASP A OD1 1 
ATOM   433  O OD2 . ASP A 1 92 ? -0.483  24.703  -21.739 1.00 40.05 ? 802 ASP A OD2 1 
ATOM   434  N N   . VAL A 1 93 ? 0.576   29.314  -18.770 1.00 30.03 ? 803 VAL A N   1 
ATOM   435  C CA  . VAL A 1 93 ? 0.399   30.209  -17.636 1.00 30.78 ? 803 VAL A CA  1 
ATOM   436  C C   . VAL A 1 93 ? 0.348   31.660  -18.112 1.00 34.68 ? 803 VAL A C   1 
ATOM   437  O O   . VAL A 1 93 ? -0.564  32.410  -17.757 1.00 36.05 ? 803 VAL A O   1 
ATOM   438  C CB  . VAL A 1 93 ? 1.504   29.985  -16.587 1.00 30.11 ? 803 VAL A CB  1 
ATOM   439  C CG1 . VAL A 1 93 ? 1.386   30.984  -15.466 1.00 30.01 ? 803 VAL A CG1 1 
ATOM   440  C CG2 . VAL A 1 93 ? 1.400   28.626  -15.999 1.00 25.56 ? 803 VAL A CG2 1 
ATOM   441  N N   . TRP A 1 94 ? 1.325   32.074  -18.926 1.00 36.69 ? 804 TRP A N   1 
ATOM   442  C CA  . TRP A 1 94 ? 1.327   33.452  -19.424 1.00 39.91 ? 804 TRP A CA  1 
ATOM   443  C C   . TRP A 1 94 ? 0.081   33.763  -20.241 1.00 39.73 ? 804 TRP A C   1 
ATOM   444  O O   . TRP A 1 94 ? -0.528  34.829  -20.071 1.00 43.38 ? 804 TRP A O   1 
ATOM   445  C CB  . TRP A 1 94 ? 2.565   33.713  -20.279 1.00 42.93 ? 804 TRP A CB  1 
ATOM   446  C CG  . TRP A 1 94 ? 2.679   35.146  -20.640 1.00 43.21 ? 804 TRP A CG  1 
ATOM   447  C CD1 . TRP A 1 94 ? 2.401   35.728  -21.852 1.00 45.92 ? 804 TRP A CD1 1 
ATOM   448  C CD2 . TRP A 1 94 ? 3.053   36.206  -19.758 1.00 43.17 ? 804 TRP A CD2 1 
ATOM   449  N NE1 . TRP A 1 94 ? 2.611   37.087  -21.780 1.00 44.24 ? 804 TRP A NE1 1 
ATOM   450  C CE2 . TRP A 1 94 ? 3.009   37.407  -20.502 1.00 47.01 ? 804 TRP A CE2 1 
ATOM   451  C CE3 . TRP A 1 94 ? 3.435   36.257  -18.412 1.00 41.90 ? 804 TRP A CE3 1 
ATOM   452  C CZ2 . TRP A 1 94 ? 3.333   38.649  -19.938 1.00 44.54 ? 804 TRP A CZ2 1 
ATOM   453  C CZ3 . TRP A 1 94 ? 3.758   37.488  -17.852 1.00 48.20 ? 804 TRP A CZ3 1 
ATOM   454  C CH2 . TRP A 1 94 ? 3.703   38.669  -18.613 1.00 45.45 ? 804 TRP A CH2 1 
ATOM   455  N N   . ASP A 1 95 ? -0.311  32.849  -21.122 1.00 35.01 ? 805 ASP A N   1 
ATOM   456  C CA  . ASP A 1 95 ? -1.490  32.996  -21.959 1.00 37.50 ? 805 ASP A CA  1 
ATOM   457  C C   . ASP A 1 95 ? -2.793  33.069  -21.144 1.00 38.10 ? 805 ASP A C   1 
ATOM   458  O O   . ASP A 1 95 ? -3.873  33.177  -21.739 1.00 42.24 ? 805 ASP A O   1 
ATOM   459  C CB  . ASP A 1 95 ? -1.507  31.831  -22.963 1.00 38.39 ? 805 ASP A CB  1 
ATOM   460  C CG  . ASP A 1 95 ? -0.400  31.949  -24.032 1.00 40.93 ? 805 ASP A CG  1 
ATOM   461  O OD1 . ASP A 1 95 ? 0.774   32.278  -23.707 1.00 39.24 ? 805 ASP A OD1 1 
ATOM   462  O OD2 . ASP A 1 95 ? -0.682  31.660  -25.205 1.00 49.06 ? 805 ASP A OD2 1 
ATOM   463  N N   . THR A 1 96 ? -2.725  33.027  -19.808 1.00 38.00 ? 806 THR A N   1 
ATOM   464  C CA  . THR A 1 96 ? -3.888  33.289  -18.966 1.00 39.01 ? 806 THR A CA  1 
ATOM   465  C C   . THR A 1 96 ? -3.671  34.317  -17.832 1.00 42.47 ? 806 THR A C   1 
ATOM   466  O O   . THR A 1 96 ? -4.663  34.899  -17.366 1.00 40.33 ? 806 THR A O   1 
ATOM   467  C CB  . THR A 1 96 ? -4.432  31.973  -18.384 1.00 32.23 ? 806 THR A CB  1 
ATOM   468  O OG1 . THR A 1 96 ? -5.451  32.265  -17.418 1.00 38.22 ? 806 THR A OG1 1 
ATOM   469  C CG2 . THR A 1 96 ? -3.338  31.154  -17.722 1.00 29.76 ? 806 THR A CG2 1 
ATOM   470  N N   . VAL A 1 97 ? -2.433  34.603  -17.411 1.00 37.96 ? 807 VAL A N   1 
ATOM   471  C CA  . VAL A 1 97 ? -2.196  35.785  -16.582 1.00 38.42 ? 807 VAL A CA  1 
ATOM   472  C C   . VAL A 1 97 ? -1.529  36.878  -17.414 1.00 42.67 ? 807 VAL A C   1 
ATOM   473  O O   . VAL A 1 97 ? -0.309  37.074  -17.371 1.00 42.58 ? 807 VAL A O   1 
ATOM   474  C CB  . VAL A 1 97 ? -1.387  35.443  -15.320 1.00 34.94 ? 807 VAL A CB  1 
ATOM   475  C CG1 . VAL A 1 97 ? -2.184  34.515  -14.475 1.00 37.52 ? 807 VAL A CG1 1 
ATOM   476  C CG2 . VAL A 1 97 ? -0.112  34.724  -15.686 1.00 45.80 ? 807 VAL A CG2 1 
ATOM   477  N N   . GLY A 1 98 ? -2.340  37.585  -18.198 1.00 43.43 ? 808 GLY A N   1 
ATOM   478  C CA  . GLY A 1 98 ? -1.889  38.766  -18.919 1.00 47.26 ? 808 GLY A CA  1 
ATOM   479  C C   . GLY A 1 98 ? -0.605  38.621  -19.707 1.00 42.28 ? 808 GLY A C   1 
ATOM   480  O O   . GLY A 1 98 ? -0.108  39.615  -20.235 1.00 43.14 ? 808 GLY A O   1 
ATOM   481  N N   . ALA B 1 32 ? -18.340 9.058   -2.156  1.00 65.80 ? 742 ALA B N   1 
ATOM   482  C CA  . ALA B 1 32 ? -18.797 10.438  -2.349  1.00 55.64 ? 742 ALA B CA  1 
ATOM   483  C C   . ALA B 1 32 ? -19.841 10.805  -1.308  1.00 54.29 ? 742 ALA B C   1 
ATOM   484  O O   . ALA B 1 32 ? -21.025 10.889  -1.618  1.00 57.19 ? 742 ALA B O   1 
ATOM   485  C CB  . ALA B 1 32 ? -19.361 10.634  -3.751  1.00 46.33 ? 742 ALA B CB  1 
ATOM   486  N N   . THR B 1 33 ? -19.383 11.029  -0.075  1.00 58.06 ? 743 THR B N   1 
ATOM   487  C CA  . THR B 1 33 ? -20.245 11.333  1.063   1.00 52.77 ? 743 THR B CA  1 
ATOM   488  C C   . THR B 1 33 ? -20.891 12.717  0.913   1.00 50.28 ? 743 THR B C   1 
ATOM   489  O O   . THR B 1 33 ? -20.790 13.391  -0.111  1.00 51.26 ? 743 THR B O   1 
ATOM   490  C CB  . THR B 1 33 ? -19.461 11.249  2.375   1.00 54.41 ? 743 THR B CB  1 
ATOM   491  O OG1 . THR B 1 33 ? -18.661 12.431  2.545   1.00 45.20 ? 743 THR B OG1 1 
ATOM   492  C CG2 . THR B 1 33 ? -18.566 10.008  2.391   1.00 54.06 ? 743 THR B CG2 1 
ATOM   493  N N   . MET B 1 34 ? -21.563 13.148  1.980   1.00 44.48 ? 744 MET B N   1 
ATOM   494  C CA  . MET B 1 34 ? -22.323 14.385  1.910   1.00 44.06 ? 744 MET B CA  1 
ATOM   495  C C   . MET B 1 34 ? -21.391 15.597  1.912   1.00 45.73 ? 744 MET B C   1 
ATOM   496  O O   . MET B 1 34 ? -21.548 16.506  1.093   1.00 46.11 ? 744 MET B O   1 
ATOM   497  C CB  . MET B 1 34 ? -23.311 14.417  3.074   1.00 48.49 ? 744 MET B CB  1 
ATOM   498  C CG  . MET B 1 34 ? -24.585 15.199  2.829   1.00 45.33 ? 744 MET B CG  1 
ATOM   499  S SD  . MET B 1 34 ? -25.140 14.998  1.127   1.00 63.79 ? 744 MET B SD  1 
ATOM   500  C CE  . MET B 1 34 ? -25.738 13.299  1.100   1.00 49.91 ? 744 MET B CE  1 
ATOM   501  N N   . ALA B 1 35 ? -20.392 15.605  2.805   1.00 46.39 ? 745 ALA B N   1 
ATOM   502  C CA  . ALA B 1 35 ? -19.345 16.622  2.770   1.00 41.29 ? 745 ALA B CA  1 
ATOM   503  C C   . ALA B 1 35 ? -18.744 16.769  1.378   1.00 39.70 ? 745 ALA B C   1 
ATOM   504  O O   . ALA B 1 35 ? -18.443 17.882  0.949   1.00 48.92 ? 745 ALA B O   1 
ATOM   505  C CB  . ALA B 1 35 ? -18.249 16.281  3.782   1.00 45.34 ? 745 ALA B CB  1 
ATOM   506  N N   . ASP B 1 36 ? -18.559 15.665  0.660   1.00 38.63 ? 746 ASP B N   1 
ATOM   507  C CA  . ASP B 1 36 ? -18.127 15.747  -0.734  1.00 40.86 ? 746 ASP B CA  1 
ATOM   508  C C   . ASP B 1 36 ? -19.116 16.525  -1.590  1.00 42.35 ? 746 ASP B C   1 
ATOM   509  O O   . ASP B 1 36 ? -18.710 17.351  -2.421  1.00 38.37 ? 746 ASP B O   1 
ATOM   510  C CB  . ASP B 1 36 ? -17.908 14.334  -1.284  1.00 50.82 ? 746 ASP B CB  1 
ATOM   511  C CG  . ASP B 1 36 ? -16.887 13.534  -0.470  1.00 49.52 ? 746 ASP B CG  1 
ATOM   512  O OD1 . ASP B 1 36 ? -16.029 14.147  0.190   1.00 53.36 ? 746 ASP B OD1 1 
ATOM   513  O OD2 . ASP B 1 36 ? -16.965 12.294  -0.434  1.00 49.42 ? 746 ASP B OD2 1 
ATOM   514  N N   . LEU B 1 37 ? -20.422 16.286  -1.410  1.00 46.12 ? 747 LEU B N   1 
ATOM   515  C CA  . LEU B 1 37 ? -21.423 16.973  -2.219  1.00 40.81 ? 747 LEU B CA  1 
ATOM   516  C C   . LEU B 1 37 ? -21.511 18.449  -1.846  1.00 39.64 ? 747 LEU B C   1 
ATOM   517  O O   . LEU B 1 37 ? -21.509 19.315  -2.723  1.00 48.15 ? 747 LEU B O   1 
ATOM   518  C CB  . LEU B 1 37 ? -22.798 16.312  -2.082  1.00 46.02 ? 747 LEU B CB  1 
ATOM   519  C CG  . LEU B 1 37 ? -23.008 14.855  -2.510  1.00 46.84 ? 747 LEU B CG  1 
ATOM   520  C CD1 . LEU B 1 37 ? -24.508 14.582  -2.656  1.00 52.75 ? 747 LEU B CD1 1 
ATOM   521  C CD2 . LEU B 1 37 ? -22.256 14.511  -3.787  1.00 48.46 ? 747 LEU B CD2 1 
ATOM   522  N N   . LYS B 1 38 ? -21.604 18.750  -0.544  1.00 34.96 ? 748 LYS B N   1 
ATOM   523  C CA  . LYS B 1 38 ? -21.563 20.141  -0.082  1.00 33.98 ? 748 LYS B CA  1 
ATOM   524  C C   . LYS B 1 38 ? -20.323 20.868  -0.598  1.00 38.54 ? 748 LYS B C   1 
ATOM   525  O O   . LYS B 1 38 ? -20.428 21.893  -1.285  1.00 37.68 ? 748 LYS B O   1 
ATOM   526  C CB  . LYS B 1 38 ? -21.622 20.188  1.452   1.00 32.35 ? 748 LYS B CB  1 
ATOM   527  C CG  . LYS B 1 38 ? -22.995 19.910  2.050   1.00 35.66 ? 748 LYS B CG  1 
ATOM   528  C CD  . LYS B 1 38 ? -22.916 19.419  3.508   1.00 41.20 ? 748 LYS B CD  1 
ATOM   529  C CE  . LYS B 1 38 ? -22.424 20.454  4.508   1.00 37.42 ? 748 LYS B CE  1 
ATOM   530  N NZ  . LYS B 1 38 ? -22.681 19.960  5.894   1.00 31.08 ? 748 LYS B NZ  1 
ATOM   531  N N   . MET B 1 39 ? -19.130 20.351  -0.280  1.00 37.42 ? 749 MET B N   1 
ATOM   532  C CA  . MET B 1 39 ? -17.894 21.054  -0.605  1.00 32.72 ? 749 MET B CA  1 
ATOM   533  C C   . MET B 1 39 ? -17.740 21.269  -2.102  1.00 35.71 ? 749 MET B C   1 
ATOM   534  O O   . MET B 1 39 ? -17.109 22.240  -2.522  1.00 37.41 ? 749 MET B O   1 
ATOM   535  C CB  . MET B 1 39 ? -16.678 20.292  -0.078  1.00 42.06 ? 749 MET B CB  1 
ATOM   536  C CG  . MET B 1 39 ? -15.328 20.971  -0.388  1.00 43.17 ? 749 MET B CG  1 
ATOM   537  S SD  . MET B 1 39 ? -15.034 22.515  0.499   1.00 40.63 ? 749 MET B SD  1 
ATOM   538  C CE  . MET B 1 39 ? -13.252 22.717  0.304   1.00 46.08 ? 749 MET B CE  1 
ATOM   539  N N   . GLN B 1 40 ? -18.259 20.343  -2.916  1.00 36.14 ? 750 GLN B N   1 
ATOM   540  C CA  . GLN B 1 40 ? -18.321 20.590  -4.357  1.00 34.28 ? 750 GLN B CA  1 
ATOM   541  C C   . GLN B 1 40 ? -19.335 21.689  -4.662  1.00 35.74 ? 750 GLN B C   1 
ATOM   542  O O   . GLN B 1 40 ? -19.056 22.612  -5.444  1.00 35.78 ? 750 GLN B O   1 
ATOM   543  C CB  . GLN B 1 40 ? -18.673 19.298  -5.096  1.00 29.96 ? 750 GLN B CB  1 
ATOM   544  C CG  . GLN B 1 40 ? -18.205 19.222  -6.543  1.00 25.22 ? 750 GLN B CG  1 
ATOM   545  C CD  . GLN B 1 40 ? -16.710 19.517  -6.728  1.00 29.44 ? 750 GLN B CD  1 
ATOM   546  O OE1 . GLN B 1 40 ? -15.874 19.329  -5.824  1.00 22.39 ? 750 GLN B OE1 1 
ATOM   547  N NE2 . GLN B 1 40 ? -16.369 19.959  -7.928  1.00 36.56 ? 750 GLN B NE2 1 
ATOM   548  N N   . ALA B 1 41 ? -20.501 21.625  -4.024  1.00 34.40 ? 751 ALA B N   1 
ATOM   549  C CA  . ALA B 1 41 ? -21.533 22.626  -4.262  1.00 36.62 ? 751 ALA B CA  1 
ATOM   550  C C   . ALA B 1 41 ? -20.996 24.039  -4.011  1.00 36.26 ? 751 ALA B C   1 
ATOM   551  O O   . ALA B 1 41 ? -21.196 24.949  -4.827  1.00 33.19 ? 751 ALA B O   1 
ATOM   552  C CB  . ALA B 1 41 ? -22.749 22.303  -3.385  1.00 36.43 ? 751 ALA B CB  1 
ATOM   553  N N   . VAL B 1 42 ? -20.280 24.230  -2.898  1.00 33.76 ? 752 VAL B N   1 
ATOM   554  C CA  . VAL B 1 42 ? -19.725 25.538  -2.566  1.00 29.89 ? 752 VAL B CA  1 
ATOM   555  C C   . VAL B 1 42 ? -18.699 25.958  -3.613  1.00 31.58 ? 752 VAL B C   1 
ATOM   556  O O   . VAL B 1 42 ? -18.746 27.081  -4.128  1.00 34.31 ? 752 VAL B O   1 
ATOM   557  C CB  . VAL B 1 42 ? -19.127 25.532  -1.146  1.00 30.16 ? 752 VAL B CB  1 
ATOM   558  C CG1 . VAL B 1 42 ? -18.116 26.646  -0.973  1.00 28.83 ? 752 VAL B CG1 1 
ATOM   559  C CG2 . VAL B 1 42 ? -20.218 25.666  -0.098  1.00 31.52 ? 752 VAL B CG2 1 
ATOM   560  N N   . LYS B 1 43 ? -17.775 25.051  -3.956  1.00 30.87 ? 753 LYS B N   1 
ATOM   561  C CA  . LYS B 1 43 ? -16.753 25.378  -4.950  1.00 28.70 ? 753 LYS B CA  1 
ATOM   562  C C   . LYS B 1 43 ? -17.368 25.777  -6.280  1.00 30.69 ? 753 LYS B C   1 
ATOM   563  O O   . LYS B 1 43 ? -16.812 26.621  -6.986  1.00 27.76 ? 753 LYS B O   1 
ATOM   564  C CB  . LYS B 1 43 ? -15.824 24.192  -5.169  1.00 30.33 ? 753 LYS B CB  1 
ATOM   565  C CG  . LYS B 1 43 ? -14.833 23.957  -4.066  1.00 33.95 ? 753 LYS B CG  1 
ATOM   566  C CD  . LYS B 1 43 ? -13.844 22.891  -4.478  1.00 39.60 ? 753 LYS B CD  1 
ATOM   567  C CE  . LYS B 1 43 ? -13.117 22.331  -3.278  1.00 47.67 ? 753 LYS B CE  1 
ATOM   568  N NZ  . LYS B 1 43 ? -11.833 21.689  -3.673  1.00 63.00 ? 753 LYS B NZ  1 
ATOM   569  N N   . GLU B 1 44 ? -18.496 25.170  -6.650  1.00 32.94 ? 754 GLU B N   1 
ATOM   570  C CA  . GLU B 1 44 ? -19.118 25.457  -7.931  1.00 29.98 ? 754 GLU B CA  1 
ATOM   571  C C   . GLU B 1 44 ? -20.108 26.592  -7.889  1.00 30.75 ? 754 GLU B C   1 
ATOM   572  O O   . GLU B 1 44 ? -20.498 27.077  -8.952  1.00 31.49 ? 754 GLU B O   1 
ATOM   573  C CB  . GLU B 1 44 ? -19.863 24.254  -8.486  1.00 32.57 ? 754 GLU B CB  1 
ATOM   574  C CG  . GLU B 1 44 ? -19.047 23.216  -9.138  1.00 35.04 ? 754 GLU B CG  1 
ATOM   575  C CD  . GLU B 1 44 ? -19.948 22.161  -9.664  1.00 41.30 ? 754 GLU B CD  1 
ATOM   576  O OE1 . GLU B 1 44 ? -19.506 21.005  -9.844  1.00 46.74 ? 754 GLU B OE1 1 
ATOM   577  O OE2 . GLU B 1 44 ? -21.136 22.505  -9.850  1.00 48.86 ? 754 GLU B OE2 1 
ATOM   578  N N   . ILE B 1 45 ? -20.592 26.969  -6.717  1.00 29.94 ? 755 ILE B N   1 
ATOM   579  C CA  . ILE B 1 45 ? -21.399 28.174  -6.636  1.00 37.17 ? 755 ILE B CA  1 
ATOM   580  C C   . ILE B 1 45 ? -20.520 29.397  -6.463  1.00 33.78 ? 755 ILE B C   1 
ATOM   581  O O   . ILE B 1 45 ? -20.806 30.454  -7.022  1.00 32.86 ? 755 ILE B O   1 
ATOM   582  C CB  . ILE B 1 45 ? -22.462 28.045  -5.522  1.00 40.12 ? 755 ILE B CB  1 
ATOM   583  C CG1 . ILE B 1 45 ? -23.429 26.912  -5.882  1.00 39.35 ? 755 ILE B CG1 1 
ATOM   584  C CG2 . ILE B 1 45 ? -23.201 29.377  -5.287  1.00 29.10 ? 755 ILE B CG2 1 
ATOM   585  C CD1 . ILE B 1 45 ? -24.643 26.856  -5.021  1.00 42.85 ? 755 ILE B CD1 1 
ATOM   586  N N   . CYS B 1 46 ? -19.404 29.238  -5.742  1.00 34.97 ? 756 CYS B N   1 
ATOM   587  C CA  . CYS B 1 46 ? -18.378 30.273  -5.678  1.00 32.33 ? 756 CYS B CA  1 
ATOM   588  C C   . CYS B 1 46 ? -17.789 30.603  -7.051  1.00 28.40 ? 756 CYS B C   1 
ATOM   589  O O   . CYS B 1 46 ? -17.184 31.660  -7.218  1.00 27.60 ? 756 CYS B O   1 
ATOM   590  C CB  . CYS B 1 46 ? -17.270 29.816  -4.733  1.00 26.03 ? 756 CYS B CB  1 
ATOM   591  S SG  . CYS B 1 46 ? -17.499 30.346  -3.038  1.00 24.50 ? 756 CYS B SG  1 
ATOM   592  N N   . TYR B 1 47 ? -17.943 29.718  -8.031  1.00 29.66 ? 757 TYR B N   1 
ATOM   593  C CA  . TYR B 1 47 ? -17.494 29.941  -9.401  1.00 33.99 ? 757 TYR B CA  1 
ATOM   594  C C   . TYR B 1 47 ? -18.580 30.629  -10.239 1.00 34.95 ? 757 TYR B C   1 
ATOM   595  O O   . TYR B 1 47 ? -18.302 31.629  -10.908 1.00 37.06 ? 757 TYR B O   1 
ATOM   596  C CB  . TYR B 1 47 ? -17.048 28.590  -9.998  1.00 34.91 ? 757 TYR B CB  1 
ATOM   597  C CG  . TYR B 1 47 ? -16.480 28.560  -11.412 1.00 31.77 ? 757 TYR B CG  1 
ATOM   598  C CD1 . TYR B 1 47 ? -17.259 28.182  -12.489 1.00 32.90 ? 757 TYR B CD1 1 
ATOM   599  C CD2 . TYR B 1 47 ? -15.150 28.879  -11.655 1.00 30.75 ? 757 TYR B CD2 1 
ATOM   600  C CE1 . TYR B 1 47 ? -16.735 28.132  -13.766 1.00 35.27 ? 757 TYR B CE1 1 
ATOM   601  C CE2 . TYR B 1 47 ? -14.620 28.833  -12.932 1.00 30.06 ? 757 TYR B CE2 1 
ATOM   602  C CZ  . TYR B 1 47 ? -15.416 28.455  -13.982 1.00 32.30 ? 757 TYR B CZ  1 
ATOM   603  O OH  . TYR B 1 47 ? -14.893 28.407  -15.258 1.00 31.94 ? 757 TYR B OH  1 
ATOM   604  N N   . GLU B 1 48 ? -19.823 30.132  -10.192 1.00 32.90 ? 758 GLU B N   1 
ATOM   605  C CA  . GLU B 1 48 ? -20.932 30.834  -10.834 1.00 33.42 ? 758 GLU B CA  1 
ATOM   606  C C   . GLU B 1 48 ? -21.101 32.243  -10.257 1.00 37.94 ? 758 GLU B C   1 
ATOM   607  O O   . GLU B 1 48 ? -21.305 33.208  -11.004 1.00 36.72 ? 758 GLU B O   1 
ATOM   608  C CB  . GLU B 1 48 ? -22.227 30.016  -10.696 1.00 35.12 ? 758 GLU B CB  1 
ATOM   609  C CG  . GLU B 1 48 ? -22.102 28.542  -11.143 1.00 50.91 ? 758 GLU B CG  1 
ATOM   610  C CD  . GLU B 1 48 ? -23.303 27.661  -10.748 1.00 58.05 ? 758 GLU B CD  1 
ATOM   611  O OE1 . GLU B 1 48 ? -24.436 28.201  -10.757 1.00 62.53 ? 758 GLU B OE1 1 
ATOM   612  O OE2 . GLU B 1 48 ? -23.109 26.443  -10.440 1.00 44.90 ? 758 GLU B OE2 1 
ATOM   613  N N   . VAL B 1 49 ? -21.008 32.381  -8.929  1.00 37.95 ? 759 VAL B N   1 
ATOM   614  C CA  . VAL B 1 49 ? -21.069 33.701  -8.296  1.00 41.65 ? 759 VAL B CA  1 
ATOM   615  C C   . VAL B 1 49 ? -19.920 34.594  -8.761  1.00 37.50 ? 759 VAL B C   1 
ATOM   616  O O   . VAL B 1 49 ? -20.067 35.821  -8.818  1.00 37.37 ? 759 VAL B O   1 
ATOM   617  C CB  . VAL B 1 49 ? -21.104 33.571  -6.751  1.00 37.91 ? 759 VAL B CB  1 
ATOM   618  C CG1 . VAL B 1 49 ? -20.855 34.896  -6.081  1.00 42.02 ? 759 VAL B CG1 1 
ATOM   619  C CG2 . VAL B 1 49 ? -22.468 33.105  -6.293  1.00 32.80 ? 759 VAL B CG2 1 
ATOM   620  N N   . ALA B 1 50 ? -18.773 34.011  -9.104  1.00 34.63 ? 760 ALA B N   1 
ATOM   621  C CA  . ALA B 1 50 ? -17.624 34.835  -9.446  1.00 32.68 ? 760 ALA B CA  1 
ATOM   622  C C   . ALA B 1 50 ? -17.653 35.255  -10.899 1.00 35.42 ? 760 ALA B C   1 
ATOM   623  O O   . ALA B 1 50 ? -17.467 36.437  -11.193 1.00 42.62 ? 760 ALA B O   1 
ATOM   624  C CB  . ALA B 1 50 ? -16.312 34.107  -9.150  1.00 30.67 ? 760 ALA B CB  1 
ATOM   625  N N   . LEU B 1 51 ? -17.876 34.318  -11.823 1.00 33.22 ? 761 LEU B N   1 
ATOM   626  C CA  . LEU B 1 51 ? -17.824 34.707  -13.227 1.00 36.47 ? 761 LEU B CA  1 
ATOM   627  C C   . LEU B 1 51 ? -19.006 35.596  -13.610 1.00 43.05 ? 761 LEU B C   1 
ATOM   628  O O   . LEU B 1 51 ? -18.870 36.434  -14.511 1.00 43.04 ? 761 LEU B O   1 
ATOM   629  C CB  . LEU B 1 51 ? -17.741 33.473  -14.114 1.00 32.64 ? 761 LEU B CB  1 
ATOM   630  C CG  . LEU B 1 51 ? -16.375 32.766  -14.076 1.00 33.52 ? 761 LEU B CG  1 
ATOM   631  C CD1 . LEU B 1 51 ? -16.334 31.639  -15.086 1.00 32.48 ? 761 LEU B CD1 1 
ATOM   632  C CD2 . LEU B 1 51 ? -15.201 33.694  -14.266 1.00 29.75 ? 761 LEU B CD2 1 
ATOM   633  N N   . ALA B 1 52 ? -20.144 35.476  -12.907 1.00 38.69 ? 762 ALA B N   1 
ATOM   634  C CA  . ALA B 1 52 ? -21.243 36.428  -13.005 1.00 37.96 ? 762 ALA B CA  1 
ATOM   635  C C   . ALA B 1 52 ? -20.927 37.781  -12.344 1.00 44.59 ? 762 ALA B C   1 
ATOM   636  O O   . ALA B 1 52 ? -21.853 38.537  -12.002 1.00 40.53 ? 762 ALA B O   1 
ATOM   637  C CB  . ALA B 1 52 ? -22.517 35.818  -12.413 1.00 34.00 ? 762 ALA B CB  1 
ATOM   638  N N   . ASP B 1 53 ? -19.639 38.096  -12.146 1.00 42.84 ? 763 ASP B N   1 
ATOM   639  C CA  . ASP B 1 53 ? -19.195 39.414  -11.679 1.00 46.45 ? 763 ASP B CA  1 
ATOM   640  C C   . ASP B 1 53 ? -19.709 39.751  -10.279 1.00 46.47 ? 763 ASP B C   1 
ATOM   641  O O   . ASP B 1 53 ? -19.852 40.922  -9.938  1.00 55.06 ? 763 ASP B O   1 
ATOM   642  C CB  . ASP B 1 53 ? -19.606 40.526  -12.658 1.00 51.43 ? 763 ASP B CB  1 
ATOM   643  C CG  . ASP B 1 53 ? -19.457 40.113  -14.127 1.00 54.37 ? 763 ASP B CG  1 
ATOM   644  O OD1 . ASP B 1 53 ? -18.386 39.579  -14.479 1.00 52.32 ? 763 ASP B OD1 1 
ATOM   645  O OD2 . ASP B 1 53 ? -20.424 40.283  -14.913 1.00 49.80 ? 763 ASP B OD2 1 
ATOM   646  N N   . PHE B 1 54 ? -19.974 38.746  -9.447  1.00 46.51 ? 764 PHE B N   1 
ATOM   647  C CA  . PHE B 1 54 ? -20.530 38.942  -8.097  1.00 51.37 ? 764 PHE B CA  1 
ATOM   648  C C   . PHE B 1 54 ? -21.825 39.766  -8.118  1.00 52.19 ? 764 PHE B C   1 
ATOM   649  O O   . PHE B 1 54 ? -22.002 40.718  -7.348  1.00 44.87 ? 764 PHE B O   1 
ATOM   650  C CB  . PHE B 1 54 ? -19.506 39.560  -7.134  1.00 48.62 ? 764 PHE B CB  1 
ATOM   651  C CG  . PHE B 1 54 ? -18.400 38.614  -6.713  1.00 44.71 ? 764 PHE B CG  1 
ATOM   652  C CD1 . PHE B 1 54 ? -18.645 37.593  -5.804  1.00 39.55 ? 764 PHE B CD1 1 
ATOM   653  C CD2 . PHE B 1 54 ? -17.102 38.790  -7.162  1.00 40.57 ? 764 PHE B CD2 1 
ATOM   654  C CE1 . PHE B 1 54 ? -17.621 36.726  -5.412  1.00 35.30 ? 764 PHE B CE1 1 
ATOM   655  C CE2 . PHE B 1 54 ? -16.076 37.935  -6.756  1.00 34.05 ? 764 PHE B CE2 1 
ATOM   656  C CZ  . PHE B 1 54 ? -16.341 36.905  -5.887  1.00 29.95 ? 764 PHE B CZ  1 
ATOM   657  N N   . ARG B 1 55 ? -22.747 39.366  -9.013  1.00 53.21 ? 765 ARG B N   1 
ATOM   658  C CA  . ARG B 1 55 ? -24.111 39.889  -9.107  1.00 48.80 ? 765 ARG B CA  1 
ATOM   659  C C   . ARG B 1 55 ? -25.084 39.190  -8.165  1.00 50.09 ? 765 ARG B C   1 
ATOM   660  O O   . ARG B 1 55 ? -26.248 39.607  -8.068  1.00 41.24 ? 765 ARG B O   1 
ATOM   661  C CB  . ARG B 1 55 ? -24.640 39.740  -10.542 1.00 44.01 ? 765 ARG B CB  1 
ATOM   662  C CG  . ARG B 1 55 ? -24.107 40.748  -11.529 1.00 43.23 ? 765 ARG B CG  1 
ATOM   663  C CD  . ARG B 1 55 ? -25.150 41.804  -11.822 1.00 40.26 ? 765 ARG B CD  1 
ATOM   664  N N   . HIS B 1 56 ? -24.643 38.125  -7.498  1.00 54.37 ? 766 HIS B N   1 
ATOM   665  C CA  . HIS B 1 56 ? -25.523 37.292  -6.697  1.00 48.39 ? 766 HIS B CA  1 
ATOM   666  C C   . HIS B 1 56 ? -25.492 37.711  -5.237  1.00 42.97 ? 766 HIS B C   1 
ATOM   667  O O   . HIS B 1 56 ? -24.413 37.867  -4.645  1.00 36.93 ? 766 HIS B O   1 
ATOM   668  C CB  . HIS B 1 56 ? -25.129 35.829  -6.836  1.00 45.28 ? 766 HIS B CB  1 
ATOM   669  C CG  . HIS B 1 56 ? -25.159 35.332  -8.245  1.00 51.43 ? 766 HIS B CG  1 
ATOM   670  N ND1 . HIS B 1 56 ? -26.270 34.721  -8.787  1.00 54.76 ? 766 HIS B ND1 1 
ATOM   671  C CD2 . HIS B 1 56 ? -24.227 35.365  -9.223  1.00 52.82 ? 766 HIS B CD2 1 
ATOM   672  C CE1 . HIS B 1 56 ? -26.010 34.374  -10.034 1.00 61.31 ? 766 HIS B CE1 1 
ATOM   673  N NE2 . HIS B 1 56 ? -24.780 34.754  -10.328 1.00 57.85 ? 766 HIS B NE2 1 
ATOM   674  N N   . GLY B 1 57 ? -26.690 37.888  -4.673  1.00 39.55 ? 767 GLY B N   1 
ATOM   675  C CA  . GLY B 1 57 ? -26.881 38.139  -3.265  1.00 42.49 ? 767 GLY B CA  1 
ATOM   676  C C   . GLY B 1 57 ? -27.430 36.917  -2.544  1.00 43.67 ? 767 GLY B C   1 
ATOM   677  O O   . GLY B 1 57 ? -27.651 35.858  -3.128  1.00 43.98 ? 767 GLY B O   1 
ATOM   678  N N   . ARG B 1 58 ? -27.686 37.113  -1.246  1.00 42.60 ? 768 ARG B N   1 
ATOM   679  C CA  . ARG B 1 58 ? -27.924 36.023  -0.306  1.00 35.78 ? 768 ARG B CA  1 
ATOM   680  C C   . ARG B 1 58 ? -29.078 35.104  -0.724  1.00 37.80 ? 768 ARG B C   1 
ATOM   681  O O   . ARG B 1 58 ? -28.893 33.892  -0.871  1.00 42.36 ? 768 ARG B O   1 
ATOM   682  C CB  . ARG B 1 58 ? -28.187 36.603  1.079   1.00 44.97 ? 768 ARG B CB  1 
ATOM   683  C CG  . ARG B 1 58 ? -28.148 35.584  2.198   1.00 52.52 ? 768 ARG B CG  1 
ATOM   684  C CD  . ARG B 1 58 ? -26.888 34.740  2.163   1.00 53.96 ? 768 ARG B CD  1 
ATOM   685  N NE  . ARG B 1 58 ? -26.999 33.572  3.033   1.00 56.36 ? 768 ARG B NE  1 
ATOM   686  C CZ  . ARG B 1 58 ? -26.709 33.586  4.333   1.00 61.88 ? 768 ARG B CZ  1 
ATOM   687  N NH1 . ARG B 1 58 ? -26.297 34.714  4.925   1.00 53.75 ? 768 ARG B NH1 1 
ATOM   688  N NH2 . ARG B 1 58 ? -26.841 32.473  5.045   1.00 62.79 ? 768 ARG B NH2 1 
ATOM   689  N N   . ALA B 1 59 ? -30.288 35.646  -0.841  1.00 37.51 ? 769 ALA B N   1 
ATOM   690  C CA  . ALA B 1 59 ? -31.409 34.791  -1.245  1.00 38.26 ? 769 ALA B CA  1 
ATOM   691  C C   . ALA B 1 59 ? -31.178 34.213  -2.635  1.00 43.12 ? 769 ALA B C   1 
ATOM   692  O O   . ALA B 1 59 ? -31.524 33.049  -2.898  1.00 39.66 ? 769 ALA B O   1 
ATOM   693  C CB  . ALA B 1 59 ? -32.721 35.569  -1.189  1.00 30.45 ? 769 ALA B CB  1 
ATOM   694  N N   . GLU B 1 60 ? -30.581 34.996  -3.545  1.00 44.16 ? 770 GLU B N   1 
ATOM   695  C CA  . GLU B 1 60 ? -30.172 34.453  -4.834  1.00 40.11 ? 770 GLU B CA  1 
ATOM   696  C C   . GLU B 1 60 ? -29.222 33.280  -4.651  1.00 36.76 ? 770 GLU B C   1 
ATOM   697  O O   . GLU B 1 60 ? -29.296 32.297  -5.397  1.00 33.03 ? 770 GLU B O   1 
ATOM   698  C CB  . GLU B 1 60 ? -29.519 35.542  -5.692  1.00 45.99 ? 770 GLU B CB  1 
ATOM   699  C CG  . GLU B 1 60 ? -30.490 36.310  -6.615  1.00 51.73 ? 770 GLU B CG  1 
ATOM   700  C CD  . GLU B 1 60 ? -30.492 35.806  -8.072  1.00 57.29 ? 770 GLU B CD  1 
ATOM   701  O OE1 . GLU B 1 60 ? -30.161 34.627  -8.307  1.00 61.06 ? 770 GLU B OE1 1 
ATOM   702  O OE2 . GLU B 1 60 ? -30.858 36.574  -8.990  1.00 63.56 ? 770 GLU B OE2 1 
ATOM   703  N N   . ILE B 1 61 ? -28.358 33.357  -3.638  1.00 40.79 ? 771 ILE B N   1 
ATOM   704  C CA  . ILE B 1 61 ? -27.381 32.311  -3.314  1.00 39.98 ? 771 ILE B CA  1 
ATOM   705  C C   . ILE B 1 61 ? -27.988 31.192  -2.466  1.00 39.00 ? 771 ILE B C   1 
ATOM   706  O O   . ILE B 1 61 ? -27.653 30.020  -2.659  1.00 40.23 ? 771 ILE B O   1 
ATOM   707  C CB  . ILE B 1 61 ? -26.157 32.941  -2.615  1.00 38.14 ? 771 ILE B CB  1 
ATOM   708  C CG1 . ILE B 1 61 ? -25.120 33.375  -3.635  1.00 36.96 ? 771 ILE B CG1 1 
ATOM   709  C CG2 . ILE B 1 61 ? -25.548 32.007  -1.560  1.00 33.69 ? 771 ILE B CG2 1 
ATOM   710  C CD1 . ILE B 1 61 ? -24.174 34.421  -3.064  1.00 43.88 ? 771 ILE B CD1 1 
ATOM   711  N N   . GLU B 1 62 ? -28.870 31.506  -1.506  1.00 36.35 ? 772 GLU B N   1 
ATOM   712  C CA  . GLU B 1 62 ? -29.510 30.433  -0.743  1.00 40.56 ? 772 GLU B CA  1 
ATOM   713  C C   . GLU B 1 62 ? -30.228 29.436  -1.645  1.00 35.57 ? 772 GLU B C   1 
ATOM   714  O O   . GLU B 1 62 ? -30.349 28.263  -1.296  1.00 37.67 ? 772 GLU B O   1 
ATOM   715  C CB  . GLU B 1 62 ? -30.505 30.987  0.282   1.00 46.80 ? 772 GLU B CB  1 
ATOM   716  C CG  . GLU B 1 62 ? -29.897 31.632  1.507   1.00 45.43 ? 772 GLU B CG  1 
ATOM   717  C CD  . GLU B 1 62 ? -30.941 31.911  2.562   1.00 51.08 ? 772 GLU B CD  1 
ATOM   718  O OE1 . GLU B 1 62 ? -30.549 32.391  3.651   1.00 56.19 ? 772 GLU B OE1 1 
ATOM   719  O OE2 . GLU B 1 62 ? -32.149 31.645  2.291   1.00 49.88 ? 772 GLU B OE2 1 
ATOM   720  N N   . ALA B 1 63 ? -30.701 29.880  -2.804  1.00 38.68 ? 773 ALA B N   1 
ATOM   721  C CA  . ALA B 1 63 ? -31.498 29.053  -3.696  1.00 39.32 ? 773 ALA B CA  1 
ATOM   722  C C   . ALA B 1 63 ? -30.678 28.342  -4.771  1.00 39.83 ? 773 ALA B C   1 
ATOM   723  O O   . ALA B 1 63 ? -31.202 27.429  -5.423  1.00 38.65 ? 773 ALA B O   1 
ATOM   724  C CB  . ALA B 1 63 ? -32.580 29.914  -4.361  1.00 38.69 ? 773 ALA B CB  1 
ATOM   725  N N   . LEU B 1 64 ? -29.422 28.755  -4.989  1.00 39.38 ? 774 LEU B N   1 
ATOM   726  C CA  . LEU B 1 64 ? -28.542 28.033  -5.906  1.00 42.52 ? 774 LEU B CA  1 
ATOM   727  C C   . LEU B 1 64 ? -27.997 26.770  -5.259  1.00 46.45 ? 774 LEU B C   1 
ATOM   728  O O   . LEU B 1 64 ? -27.629 25.820  -5.963  1.00 46.03 ? 774 LEU B O   1 
ATOM   729  C CB  . LEU B 1 64 ? -27.376 28.924  -6.352  1.00 45.78 ? 774 LEU B CB  1 
ATOM   730  C CG  . LEU B 1 64 ? -27.347 29.584  -7.738  1.00 38.24 ? 774 LEU B CG  1 
ATOM   731  C CD1 . LEU B 1 64 ? -25.920 29.950  -8.131  1.00 36.87 ? 774 LEU B CD1 1 
ATOM   732  C CD2 . LEU B 1 64 ? -27.974 28.699  -8.787  1.00 45.41 ? 774 LEU B CD2 1 
ATOM   733  N N   . ALA B 1 65 ? -27.930 26.758  -3.921  1.00 43.96 ? 775 ALA B N   1 
ATOM   734  C CA  . ALA B 1 65 ? -27.388 25.634  -3.171  1.00 39.29 ? 775 ALA B CA  1 
ATOM   735  C C   . ALA B 1 65 ? -28.402 24.499  -3.027  1.00 45.15 ? 775 ALA B C   1 
ATOM   736  O O   . ALA B 1 65 ? -28.021 23.321  -3.049  1.00 47.78 ? 775 ALA B O   1 
ATOM   737  C CB  . ALA B 1 65 ? -26.907 26.115  -1.801  1.00 37.21 ? 775 ALA B CB  1 
ATOM   738  N N   . ALA B 1 66 ? -29.693 24.815  -2.869  1.00 45.57 ? 776 ALA B N   1 
ATOM   739  C CA  . ALA B 1 66 ? -30.692 23.757  -2.966  1.00 40.95 ? 776 ALA B CA  1 
ATOM   740  C C   . ALA B 1 66 ? -30.710 23.178  -4.373  1.00 42.55 ? 776 ALA B C   1 
ATOM   741  O O   . ALA B 1 66 ? -30.773 21.960  -4.541  1.00 50.92 ? 776 ALA B O   1 
ATOM   742  C CB  . ALA B 1 66 ? -32.073 24.264  -2.565  1.00 42.32 ? 776 ALA B CB  1 
ATOM   743  N N   . LEU B 1 67 ? -30.616 24.021  -5.402  1.00 39.45 ? 777 LEU B N   1 
ATOM   744  C CA  . LEU B 1 67 ? -30.395 23.476  -6.735  1.00 43.75 ? 777 LEU B CA  1 
ATOM   745  C C   . LEU B 1 67 ? -29.199 22.535  -6.728  1.00 43.67 ? 777 LEU B C   1 
ATOM   746  O O   . LEU B 1 67 ? -29.330 21.353  -7.052  1.00 48.03 ? 777 LEU B O   1 
ATOM   747  C CB  . LEU B 1 67 ? -30.193 24.587  -7.777  1.00 50.94 ? 777 LEU B CB  1 
ATOM   748  C CG  . LEU B 1 67 ? -29.310 24.125  -8.962  1.00 50.76 ? 777 LEU B CG  1 
ATOM   749  C CD1 . LEU B 1 67 ? -30.000 23.092  -9.870  1.00 54.05 ? 777 LEU B CD1 1 
ATOM   750  C CD2 . LEU B 1 67 ? -28.741 25.270  -9.787  1.00 50.57 ? 777 LEU B CD2 1 
ATOM   751  N N   . LYS B 1 68 ? -28.023 23.038  -6.342  1.00 42.68 ? 778 LYS B N   1 
ATOM   752  C CA  . LYS B 1 68 ? -26.807 22.236  -6.439  1.00 44.34 ? 778 LYS B CA  1 
ATOM   753  C C   . LYS B 1 68 ? -26.897 20.972  -5.582  1.00 48.94 ? 778 LYS B C   1 
ATOM   754  O O   . LYS B 1 68 ? -26.606 19.857  -6.057  1.00 45.47 ? 778 LYS B O   1 
ATOM   755  C CB  . LYS B 1 68 ? -25.588 23.079  -6.051  1.00 37.59 ? 778 LYS B CB  1 
ATOM   756  C CG  . LYS B 1 68 ? -24.471 23.092  -7.078  1.00 37.11 ? 778 LYS B CG  1 
ATOM   757  C CD  . LYS B 1 68 ? -24.798 23.957  -8.269  1.00 52.04 ? 778 LYS B CD  1 
ATOM   758  N N   . MET B 1 69 ? -27.291 21.111  -4.309  1.00 43.11 ? 779 MET B N   1 
ATOM   759  C CA  . MET B 1 69 ? -27.359 19.941  -3.451  1.00 44.51 ? 779 MET B CA  1 
ATOM   760  C C   . MET B 1 69 ? -28.299 18.895  -4.022  1.00 42.60 ? 779 MET B C   1 
ATOM   761  O O   . MET B 1 69 ? -27.924 17.743  -4.228  1.00 42.45 ? 779 MET B O   1 
ATOM   762  C CB  . MET B 1 69 ? -27.782 20.326  -2.040  1.00 45.28 ? 779 MET B CB  1 
ATOM   763  C CG  . MET B 1 69 ? -26.692 21.051  -1.296  1.00 50.74 ? 779 MET B CG  1 
ATOM   764  S SD  . MET B 1 69 ? -25.140 20.144  -1.304  1.00 45.85 ? 779 MET B SD  1 
ATOM   765  C CE  . MET B 1 69 ? -25.612 18.592  -0.520  1.00 41.35 ? 779 MET B CE  1 
ATOM   766  N N   . ARG B 1 70 ? -29.546 19.294  -4.294  1.00 44.89 ? 780 ARG B N   1 
ATOM   767  C CA  . ARG B 1 70 ? -30.511 18.375  -4.881  1.00 41.84 ? 780 ARG B CA  1 
ATOM   768  C C   . ARG B 1 70 ? -29.934 17.655  -6.089  1.00 44.57 ? 780 ARG B C   1 
ATOM   769  O O   . ARG B 1 70 ? -29.965 16.425  -6.153  1.00 46.19 ? 780 ARG B O   1 
ATOM   770  C CB  . ARG B 1 70 ? -31.784 19.126  -5.266  1.00 48.61 ? 780 ARG B CB  1 
ATOM   771  C CG  . ARG B 1 70 ? -32.548 19.676  -4.070  1.00 50.49 ? 780 ARG B CG  1 
ATOM   772  C CD  . ARG B 1 70 ? -33.919 20.246  -4.445  1.00 59.45 ? 780 ARG B CD  1 
ATOM   773  N NE  . ARG B 1 70 ? -34.915 19.185  -4.547  1.00 73.79 ? 780 ARG B NE  1 
ATOM   774  C CZ  . ARG B 1 70 ? -35.507 18.603  -3.502  1.00 81.71 ? 780 ARG B CZ  1 
ATOM   775  N NH1 . ARG B 1 70 ? -35.205 18.971  -2.259  1.00 84.76 ? 780 ARG B NH1 1 
ATOM   776  N NH2 . ARG B 1 70 ? -36.394 17.634  -3.697  1.00 86.66 ? 780 ARG B NH2 1 
ATOM   777  N N   . GLU B 1 71 ? -29.371 18.402  -7.050  1.00 48.45 ? 781 GLU B N   1 
ATOM   778  C CA  . GLU B 1 71 ? -28.853 17.792  -8.275  1.00 43.71 ? 781 GLU B CA  1 
ATOM   779  C C   . GLU B 1 71 ? -27.582 16.982  -8.039  1.00 47.21 ? 781 GLU B C   1 
ATOM   780  O O   . GLU B 1 71 ? -27.118 16.315  -8.969  1.00 48.40 ? 781 GLU B O   1 
ATOM   781  C CB  . GLU B 1 71 ? -28.546 18.842  -9.348  1.00 43.85 ? 781 GLU B CB  1 
ATOM   782  C CG  . GLU B 1 71 ? -27.176 19.503  -9.174  1.00 49.92 ? 781 GLU B CG  1 
ATOM   783  C CD  . GLU B 1 71 ? -26.565 19.979  -10.494 1.00 56.13 ? 781 GLU B CD  1 
ATOM   784  O OE1 . GLU B 1 71 ? -25.317 19.873  -10.650 1.00 47.65 ? 781 GLU B OE1 1 
ATOM   785  O OE2 . GLU B 1 71 ? -27.330 20.473  -11.362 1.00 50.68 ? 781 GLU B OE2 1 
ATOM   786  N N   . LEU B 1 72 ? -26.990 17.048  -6.843  1.00 49.72 ? 782 LEU B N   1 
ATOM   787  C CA  . LEU B 1 72 ? -25.893 16.154  -6.483  1.00 50.56 ? 782 LEU B CA  1 
ATOM   788  C C   . LEU B 1 72 ? -26.388 14.855  -5.837  1.00 52.62 ? 782 LEU B C   1 
ATOM   789  O O   . LEU B 1 72 ? -25.802 13.787  -6.054  1.00 53.66 ? 782 LEU B O   1 
ATOM   790  C CB  . LEU B 1 72 ? -24.907 16.885  -5.562  1.00 51.16 ? 782 LEU B CB  1 
ATOM   791  C CG  . LEU B 1 72 ? -24.111 18.007  -6.255  1.00 50.15 ? 782 LEU B CG  1 
ATOM   792  C CD1 . LEU B 1 72 ? -23.313 18.834  -5.265  1.00 43.58 ? 782 LEU B CD1 1 
ATOM   793  C CD2 . LEU B 1 72 ? -23.169 17.454  -7.315  1.00 42.61 ? 782 LEU B CD2 1 
ATOM   794  N N   . CYS B 1 73 ? -27.468 14.907  -5.054  1.00 51.89 ? 783 CYS B N   1 
ATOM   795  C CA  . CYS B 1 73 ? -28.079 13.667  -4.590  1.00 51.17 ? 783 CYS B CA  1 
ATOM   796  C C   . CYS B 1 73 ? -28.902 12.975  -5.672  1.00 48.03 ? 783 CYS B C   1 
ATOM   797  O O   . CYS B 1 73 ? -29.407 11.878  -5.430  1.00 56.28 ? 783 CYS B O   1 
ATOM   798  C CB  . CYS B 1 73 ? -28.951 13.942  -3.369  1.00 39.22 ? 783 CYS B CB  1 
ATOM   799  S SG  . CYS B 1 73 ? -28.054 14.759  -2.069  1.00 41.97 ? 783 CYS B SG  1 
ATOM   800  N N   . ARG B 1 74 ? -29.061 13.588  -6.841  1.00 47.95 ? 784 ARG B N   1 
ATOM   801  C CA  . ARG B 1 74 ? -29.711 12.952  -7.980  1.00 53.32 ? 784 ARG B CA  1 
ATOM   802  C C   . ARG B 1 74 ? -28.704 12.367  -8.967  1.00 59.16 ? 784 ARG B C   1 
ATOM   803  O O   . ARG B 1 74 ? -29.010 11.384  -9.660  1.00 58.93 ? 784 ARG B O   1 
ATOM   804  C CB  . ARG B 1 74 ? -30.630 13.969  -8.678  1.00 47.76 ? 784 ARG B CB  1 
ATOM   805  C CG  . ARG B 1 74 ? -31.363 13.479  -9.907  1.00 58.06 ? 784 ARG B CG  1 
ATOM   806  C CD  . ARG B 1 74 ? -32.089 12.158  -9.665  1.00 69.56 ? 784 ARG B CD  1 
ATOM   807  N NE  . ARG B 1 74 ? -33.238 12.232  -8.764  1.00 72.71 ? 784 ARG B NE  1 
ATOM   808  C CZ  . ARG B 1 74 ? -33.945 11.164  -8.398  1.00 83.09 ? 784 ARG B CZ  1 
ATOM   809  N NH1 . ARG B 1 74 ? -33.606 9.959   -8.858  1.00 81.40 ? 784 ARG B NH1 1 
ATOM   810  N NH2 . ARG B 1 74 ? -34.985 11.292  -7.579  1.00 78.97 ? 784 ARG B NH2 1 
ATOM   811  N N   . THR B 1 75 ? -27.501 12.925  -9.011  1.00 59.42 ? 785 THR B N   1 
ATOM   812  C CA  . THR B 1 75 ? -26.396 12.363  -9.774  1.00 57.62 ? 785 THR B CA  1 
ATOM   813  C C   . THR B 1 75 ? -25.596 11.336  -8.987  1.00 51.51 ? 785 THR B C   1 
ATOM   814  O O   . THR B 1 75 ? -25.003 10.437  -9.594  1.00 49.86 ? 785 THR B O   1 
ATOM   815  C CB  . THR B 1 75 ? -25.489 13.505  -10.261 1.00 51.57 ? 785 THR B CB  1 
ATOM   816  O OG1 . THR B 1 75 ? -26.313 14.486  -10.897 1.00 49.83 ? 785 THR B OG1 1 
ATOM   817  C CG2 . THR B 1 75 ? -24.436 13.023  -11.237 1.00 53.47 ? 785 THR B CG2 1 
ATOM   818  N N   . TYR B 1 76 ? -25.607 11.427  -7.655  1.00 56.24 ? 786 TYR B N   1 
ATOM   819  C CA  . TYR B 1 76 ? -24.819 10.560  -6.763  1.00 62.10 ? 786 TYR B CA  1 
ATOM   820  C C   . TYR B 1 76 ? -25.721 9.823   -5.759  1.00 59.05 ? 786 TYR B C   1 
ATOM   821  O O   . TYR B 1 76 ? -25.593 8.621   -5.536  1.00 52.98 ? 786 TYR B O   1 
ATOM   822  C CB  . TYR B 1 76 ? -23.782 11.396  -6.000  1.00 59.73 ? 786 TYR B CB  1 
ATOM   823  C CG  . TYR B 1 76 ? -22.808 12.184  -6.868  1.00 58.70 ? 786 TYR B CG  1 
ATOM   824  C CD1 . TYR B 1 76 ? -21.476 11.799  -6.992  1.00 63.67 ? 786 TYR B CD1 1 
ATOM   825  C CD2 . TYR B 1 76 ? -23.224 13.303  -7.574  1.00 56.92 ? 786 TYR B CD2 1 
ATOM   826  C CE1 . TYR B 1 76 ? -20.579 12.529  -7.785  1.00 67.66 ? 786 TYR B CE1 1 
ATOM   827  C CE2 . TYR B 1 76 ? -22.343 14.031  -8.374  1.00 64.88 ? 786 TYR B CE2 1 
ATOM   828  C CZ  . TYR B 1 76 ? -21.020 13.645  -8.474  1.00 68.38 ? 786 TYR B CZ  1 
ATOM   829  O OH  . TYR B 1 76 ? -20.146 14.371  -9.269  1.00 63.55 ? 786 TYR B OH  1 
ATOM   830  N N   . GLY B 1 83 ? -30.313 17.190  2.517   1.00 32.05 ? 793 GLY B N   1 
ATOM   831  C CA  . GLY B 1 83 ? -31.659 17.580  2.910   1.00 49.42 ? 793 GLY B CA  1 
ATOM   832  C C   . GLY B 1 83 ? -31.762 19.036  3.323   1.00 49.97 ? 793 GLY B C   1 
ATOM   833  O O   . GLY B 1 83 ? -32.390 19.856  2.638   1.00 47.09 ? 793 GLY B O   1 
ATOM   834  N N   . ASP B 1 84 ? -31.148 19.343  4.467   1.00 47.93 ? 794 ASP B N   1 
ATOM   835  C CA  . ASP B 1 84 ? -30.873 20.709  4.892   1.00 46.07 ? 794 ASP B CA  1 
ATOM   836  C C   . ASP B 1 84 ? -29.444 21.143  4.587   1.00 45.97 ? 794 ASP B C   1 
ATOM   837  O O   . ASP B 1 84 ? -29.006 22.185  5.091   1.00 49.35 ? 794 ASP B O   1 
ATOM   838  C CB  . ASP B 1 84 ? -31.160 20.870  6.394   1.00 48.68 ? 794 ASP B CB  1 
ATOM   839  C CG  . ASP B 1 84 ? -29.976 20.452  7.311   1.00 49.88 ? 794 ASP B CG  1 
ATOM   840  O OD1 . ASP B 1 84 ? -29.209 19.542  6.953   1.00 51.06 ? 794 ASP B OD1 1 
ATOM   841  O OD2 . ASP B 1 84 ? -29.834 21.012  8.427   1.00 51.72 ? 794 ASP B OD2 1 
ATOM   842  N N   . ALA B 1 85 ? -28.698 20.356  3.800   1.00 45.25 ? 795 ALA B N   1 
ATOM   843  C CA  . ALA B 1 85 ? -27.292 20.673  3.571   1.00 42.70 ? 795 ALA B CA  1 
ATOM   844  C C   . ALA B 1 85 ? -27.147 22.039  2.913   1.00 44.21 ? 795 ALA B C   1 
ATOM   845  O O   . ALA B 1 85 ? -26.193 22.780  3.203   1.00 42.47 ? 795 ALA B O   1 
ATOM   846  C CB  . ALA B 1 85 ? -26.638 19.576  2.730   1.00 36.46 ? 795 ALA B CB  1 
ATOM   847  N N   . TRP B 1 86 ? -28.120 22.409  2.078   1.00 40.83 ? 796 TRP B N   1 
ATOM   848  C CA  . TRP B 1 86 ? -28.047 23.663  1.351   1.00 38.15 ? 796 TRP B CA  1 
ATOM   849  C C   . TRP B 1 86 ? -27.835 24.842  2.299   1.00 39.09 ? 796 TRP B C   1 
ATOM   850  O O   . TRP B 1 86 ? -27.140 25.798  1.951   1.00 41.52 ? 796 TRP B O   1 
ATOM   851  C CB  . TRP B 1 86 ? -29.318 23.838  0.527   1.00 40.63 ? 796 TRP B CB  1 
ATOM   852  C CG  . TRP B 1 86 ? -30.559 24.078  1.344   1.00 45.27 ? 796 TRP B CG  1 
ATOM   853  C CD1 . TRP B 1 86 ? -31.423 23.137  1.820   1.00 50.09 ? 796 TRP B CD1 1 
ATOM   854  C CD2 . TRP B 1 86 ? -31.098 25.353  1.740   1.00 39.42 ? 796 TRP B CD2 1 
ATOM   855  N NE1 . TRP B 1 86 ? -32.451 23.745  2.510   1.00 50.82 ? 796 TRP B NE1 1 
ATOM   856  C CE2 . TRP B 1 86 ? -32.274 25.101  2.468   1.00 38.09 ? 796 TRP B CE2 1 
ATOM   857  C CE3 . TRP B 1 86 ? -30.692 26.676  1.554   1.00 48.68 ? 796 TRP B CE3 1 
ATOM   858  C CZ2 . TRP B 1 86 ? -33.053 26.126  3.002   1.00 42.08 ? 796 TRP B CZ2 1 
ATOM   859  C CZ3 . TRP B 1 86 ? -31.467 27.695  2.094   1.00 47.83 ? 796 TRP B CZ3 1 
ATOM   860  C CH2 . TRP B 1 86 ? -32.633 27.409  2.813   1.00 44.65 ? 796 TRP B CH2 1 
ATOM   861  N N   . ARG B 1 87 ? -28.405 24.773  3.509   1.00 41.75 ? 797 ARG B N   1 
ATOM   862  C CA  . ARG B 1 87 ? -28.291 25.887  4.455   1.00 41.84 ? 797 ARG B CA  1 
ATOM   863  C C   . ARG B 1 87 ? -26.832 26.145  4.832   1.00 45.00 ? 797 ARG B C   1 
ATOM   864  O O   . ARG B 1 87 ? -26.390 27.303  4.912   1.00 39.58 ? 797 ARG B O   1 
ATOM   865  C CB  . ARG B 1 87 ? -29.126 25.614  5.713   1.00 38.22 ? 797 ARG B CB  1 
ATOM   866  C CG  . ARG B 1 87 ? -30.564 26.011  5.539   1.00 44.16 ? 797 ARG B CG  1 
ATOM   867  C CD  . ARG B 1 87 ? -31.432 25.952  6.804   1.00 42.94 ? 797 ARG B CD  1 
ATOM   868  N NE  . ARG B 1 87 ? -32.838 25.924  6.398   1.00 45.34 ? 797 ARG B NE  1 
ATOM   869  C CZ  . ARG B 1 87 ? -33.546 27.007  6.092   1.00 38.53 ? 797 ARG B CZ  1 
ATOM   870  N NH1 . ARG B 1 87 ? -32.961 28.188  6.097   1.00 44.63 ? 797 ARG B NH1 1 
ATOM   871  N NH2 . ARG B 1 87 ? -34.813 26.908  5.710   1.00 38.09 ? 797 ARG B NH2 1 
ATOM   872  N N   . ALA B 1 88 ? -26.064 25.079  5.071   1.00 44.60 ? 798 ALA B N   1 
ATOM   873  C CA  . ALA B 1 88 ? -24.671 25.254  5.460   1.00 42.39 ? 798 ALA B CA  1 
ATOM   874  C C   . ALA B 1 88 ? -23.807 25.605  4.258   1.00 42.02 ? 798 ALA B C   1 
ATOM   875  O O   . ALA B 1 88 ? -22.787 26.291  4.404   1.00 38.25 ? 798 ALA B O   1 
ATOM   876  C CB  . ALA B 1 88 ? -24.159 23.987  6.147   1.00 39.93 ? 798 ALA B CB  1 
ATOM   877  N N   . VAL B 1 89 ? -24.208 25.135  3.070   1.00 40.22 ? 799 VAL B N   1 
ATOM   878  C CA  . VAL B 1 89 ? -23.524 25.449  1.823   1.00 36.54 ? 799 VAL B CA  1 
ATOM   879  C C   . VAL B 1 89 ? -23.612 26.949  1.511   1.00 37.61 ? 799 VAL B C   1 
ATOM   880  O O   . VAL B 1 89 ? -22.622 27.575  1.146   1.00 37.72 ? 799 VAL B O   1 
ATOM   881  C CB  . VAL B 1 89 ? -24.115 24.603  0.681   1.00 36.97 ? 799 VAL B CB  1 
ATOM   882  C CG1 . VAL B 1 89 ? -23.613 25.045  -0.691  1.00 32.98 ? 799 VAL B CG1 1 
ATOM   883  C CG2 . VAL B 1 89 ? -23.800 23.163  0.904   1.00 38.85 ? 799 VAL B CG2 1 
ATOM   884  N N   . ALA B 1 90 ? -24.823 27.513  1.615   1.00 38.02 ? 800 ALA B N   1 
ATOM   885  C CA  . ALA B 1 90 ? -24.989 28.940  1.327   1.00 33.69 ? 800 ALA B CA  1 
ATOM   886  C C   . ALA B 1 90 ? -24.232 29.781  2.335   1.00 38.40 ? 800 ALA B C   1 
ATOM   887  O O   . ALA B 1 90 ? -23.652 30.819  1.982   1.00 42.07 ? 800 ALA B O   1 
ATOM   888  C CB  . ALA B 1 90 ? -26.471 29.309  1.327   1.00 33.24 ? 800 ALA B CB  1 
ATOM   889  N N   . ARG B 1 91 ? -24.208 29.346  3.596   1.00 41.54 ? 801 ARG B N   1 
ATOM   890  C CA  . ARG B 1 91 ? -23.449 30.057  4.618   1.00 43.24 ? 801 ARG B CA  1 
ATOM   891  C C   . ARG B 1 91 ? -21.951 30.005  4.345   1.00 39.60 ? 801 ARG B C   1 
ATOM   892  O O   . ARG B 1 91 ? -21.248 31.003  4.536   1.00 41.98 ? 801 ARG B O   1 
ATOM   893  C CB  . ARG B 1 91 ? -23.777 29.486  5.994   1.00 50.11 ? 801 ARG B CB  1 
ATOM   894  C CG  . ARG B 1 91 ? -23.014 30.113  7.154   1.00 51.73 ? 801 ARG B CG  1 
ATOM   895  C CD  . ARG B 1 91 ? -23.717 29.834  8.477   1.00 59.42 ? 801 ARG B CD  1 
ATOM   896  N NE  . ARG B 1 91 ? -25.149 29.569  8.310   1.00 62.39 ? 801 ARG B NE  1 
ATOM   897  C CZ  . ARG B 1 91 ? -26.063 30.517  8.087   1.00 65.82 ? 801 ARG B CZ  1 
ATOM   898  N NH1 . ARG B 1 91 ? -25.693 31.787  7.990   1.00 75.29 ? 801 ARG B NH1 1 
ATOM   899  N NH2 . ARG B 1 91 ? -27.344 30.196  7.953   1.00 72.03 ? 801 ARG B NH2 1 
ATOM   900  N N   . ASP B 1 92 ? -21.445 28.860  3.892   1.00 37.72 ? 802 ASP B N   1 
ATOM   901  C CA  . ASP B 1 92 ? -20.048 28.785  3.472   1.00 39.48 ? 802 ASP B CA  1 
ATOM   902  C C   . ASP B 1 92 ? -19.785 29.671  2.261   1.00 37.17 ? 802 ASP B C   1 
ATOM   903  O O   . ASP B 1 92 ? -18.762 30.367  2.202   1.00 35.77 ? 802 ASP B O   1 
ATOM   904  C CB  . ASP B 1 92 ? -19.683 27.333  3.172   1.00 40.99 ? 802 ASP B CB  1 
ATOM   905  C CG  . ASP B 1 92 ? -19.738 26.459  4.417   1.00 47.91 ? 802 ASP B CG  1 
ATOM   906  O OD1 . ASP B 1 92 ? -19.449 26.990  5.514   1.00 44.41 ? 802 ASP B OD1 1 
ATOM   907  O OD2 . ASP B 1 92 ? -20.115 25.266  4.307   1.00 47.40 ? 802 ASP B OD2 1 
ATOM   908  N N   . VAL B 1 93 ? -20.700 29.670  1.286   1.00 38.12 ? 803 VAL B N   1 
ATOM   909  C CA  . VAL B 1 93 ? -20.561 30.524  0.111   1.00 36.30 ? 803 VAL B CA  1 
ATOM   910  C C   . VAL B 1 93 ? -20.561 31.996  0.517   1.00 36.56 ? 803 VAL B C   1 
ATOM   911  O O   . VAL B 1 93 ? -19.607 32.730  0.251   1.00 34.52 ? 803 VAL B O   1 
ATOM   912  C CB  . VAL B 1 93 ? -21.671 30.241  -0.909  1.00 33.55 ? 803 VAL B CB  1 
ATOM   913  C CG1 . VAL B 1 93 ? -21.820 31.429  -1.857  1.00 29.23 ? 803 VAL B CG1 1 
ATOM   914  C CG2 . VAL B 1 93 ? -21.357 28.970  -1.688  1.00 31.87 ? 803 VAL B CG2 1 
ATOM   915  N N   . TRP B 1 94 ? -21.646 32.426  1.167   1.00 35.54 ? 804 TRP B N   1 
ATOM   916  C CA  . TRP B 1 94 ? -21.773 33.836  1.505   1.00 36.68 ? 804 TRP B CA  1 
ATOM   917  C C   . TRP B 1 94 ? -20.552 34.320  2.282   1.00 42.54 ? 804 TRP B C   1 
ATOM   918  O O   . TRP B 1 94 ? -19.956 35.354  1.941   1.00 42.22 ? 804 TRP B O   1 
ATOM   919  C CB  . TRP B 1 94 ? -23.059 34.070  2.295   1.00 39.70 ? 804 TRP B CB  1 
ATOM   920  C CG  . TRP B 1 94 ? -23.258 35.549  2.584   1.00 46.77 ? 804 TRP B CG  1 
ATOM   921  C CD1 . TRP B 1 94 ? -23.100 36.194  3.783   1.00 39.09 ? 804 TRP B CD1 1 
ATOM   922  C CD2 . TRP B 1 94 ? -23.579 36.567  1.621   1.00 45.80 ? 804 TRP B CD2 1 
ATOM   923  N NE1 . TRP B 1 94 ? -23.333 37.540  3.624   1.00 42.59 ? 804 TRP B NE1 1 
ATOM   924  C CE2 . TRP B 1 94 ? -23.630 37.791  2.308   1.00 44.71 ? 804 TRP B CE2 1 
ATOM   925  C CE3 . TRP B 1 94 ? -23.844 36.553  0.244   1.00 44.46 ? 804 TRP B CE3 1 
ATOM   926  C CZ2 . TRP B 1 94 ? -23.940 38.985  1.668   1.00 44.24 ? 804 TRP B CZ2 1 
ATOM   927  C CZ3 . TRP B 1 94 ? -24.148 37.735  -0.383  1.00 40.77 ? 804 TRP B CZ3 1 
ATOM   928  C CH2 . TRP B 1 94 ? -24.189 38.933  0.323   1.00 41.64 ? 804 TRP B CH2 1 
ATOM   929  N N   . ASP B 1 95 ? -20.148 33.578  3.314   1.00 44.92 ? 805 ASP B N   1 
ATOM   930  C CA  . ASP B 1 95 ? -18.947 33.852  4.100   1.00 46.14 ? 805 ASP B CA  1 
ATOM   931  C C   . ASP B 1 95 ? -17.819 34.350  3.210   1.00 41.75 ? 805 ASP B C   1 
ATOM   932  O O   . ASP B 1 95 ? -17.105 35.295  3.552   1.00 50.83 ? 805 ASP B O   1 
ATOM   933  C CB  . ASP B 1 95 ? -18.463 32.577  4.803   1.00 50.45 ? 805 ASP B CB  1 
ATOM   934  C CG  . ASP B 1 95 ? -19.017 32.412  6.210   1.00 52.45 ? 805 ASP B CG  1 
ATOM   935  O OD1 . ASP B 1 95 ? -19.809 33.271  6.677   1.00 48.09 ? 805 ASP B OD1 1 
ATOM   936  O OD2 . ASP B 1 95 ? -18.633 31.397  6.844   1.00 50.42 ? 805 ASP B OD2 1 
ATOM   937  N N   . THR B 1 96 ? -17.671 33.707  2.057   1.00 36.10 ? 806 THR B N   1 
ATOM   938  C CA  . THR B 1 96 ? -16.577 33.941  1.132   1.00 36.44 ? 806 THR B CA  1 
ATOM   939  C C   . THR B 1 96 ? -16.885 35.009  0.086   1.00 41.72 ? 806 THR B C   1 
ATOM   940  O O   . THR B 1 96 ? -15.948 35.619  -0.446  1.00 40.30 ? 806 THR B O   1 
ATOM   941  C CB  . THR B 1 96 ? -16.232 32.624  0.427   1.00 39.82 ? 806 THR B CB  1 
ATOM   942  O OG1 . THR B 1 96 ? -16.065 31.592  1.408   1.00 51.10 ? 806 THR B OG1 1 
ATOM   943  C CG2 . THR B 1 96 ? -14.957 32.736  -0.371  1.00 35.13 ? 806 THR B CG2 1 
ATOM   944  N N   . VAL B 1 97 ? -18.156 35.255  -0.233  1.00 39.58 ? 807 VAL B N   1 
ATOM   945  C CA  . VAL B 1 97 ? -18.532 36.220  -1.264  1.00 36.90 ? 807 VAL B CA  1 
ATOM   946  C C   . VAL B 1 97 ? -19.394 37.357  -0.740  1.00 39.56 ? 807 VAL B C   1 
ATOM   947  O O   . VAL B 1 97 ? -19.898 38.162  -1.532  1.00 39.34 ? 807 VAL B O   1 
ATOM   948  C CB  . VAL B 1 97 ? -19.236 35.529  -2.453  1.00 28.95 ? 807 VAL B CB  1 
ATOM   949  C CG1 . VAL B 1 97 ? -18.396 34.407  -3.006  1.00 29.24 ? 807 VAL B CG1 1 
ATOM   950  C CG2 . VAL B 1 97 ? -20.602 35.033  -2.040  1.00 35.37 ? 807 VAL B CG2 1 
ATOM   951  N N   . GLY B 1 98 ? -19.599 37.453  0.567   1.00 38.96 ? 808 GLY B N   1 
ATOM   952  C CA  . GLY B 1 98 ? -20.488 38.452  1.109   1.00 34.55 ? 808 GLY B CA  1 
ATOM   953  C C   . GLY B 1 98 ? -19.927 39.082  2.366   1.00 40.81 ? 808 GLY B C   1 
ATOM   954  O O   . GLY B 1 98 ? -20.125 40.269  2.613   1.00 50.51 ? 808 GLY B O   1 
ATOM   955  N N   . MET C 2 3  ? -21.013 124.212 -8.441  1.00 44.19 ? 552 MET C N   1 
ATOM   956  C CA  . MET C 2 3  ? -19.779 124.368 -7.661  1.00 50.39 ? 552 MET C CA  1 
ATOM   957  C C   . MET C 2 3  ? -19.887 123.653 -6.327  1.00 52.44 ? 552 MET C C   1 
ATOM   958  O O   . MET C 2 3  ? -18.880 123.237 -5.759  1.00 55.89 ? 552 MET C O   1 
ATOM   959  C CB  . MET C 2 3  ? -19.429 125.848 -7.451  1.00 49.70 ? 552 MET C CB  1 
ATOM   960  C CG  . MET C 2 3  ? -18.891 126.564 -8.709  1.00 59.32 ? 552 MET C CG  1 
ATOM   961  S SD  . MET C 2 3  ? -19.404 128.304 -8.916  1.00 69.53 ? 552 MET C SD  1 
ATOM   962  C CE  . MET C 2 3  ? -17.971 129.043 -9.750  1.00 49.53 ? 552 MET C CE  1 
ATOM   963  N N   . GLU C 2 4  ? -21.105 123.509 -5.807  1.00 52.62 ? 553 GLU C N   1 
ATOM   964  C CA  . GLU C 2 4  ? -21.301 122.501 -4.771  1.00 51.64 ? 553 GLU C CA  1 
ATOM   965  C C   . GLU C 2 4  ? -21.298 121.124 -5.401  1.00 55.40 ? 553 GLU C C   1 
ATOM   966  O O   . GLU C 2 4  ? -20.682 120.187 -4.872  1.00 57.71 ? 553 GLU C O   1 
ATOM   967  C CB  . GLU C 2 4  ? -22.611 122.712 -4.008  1.00 53.17 ? 553 GLU C CB  1 
ATOM   968  C CG  . GLU C 2 4  ? -22.521 123.582 -2.740  1.00 56.40 ? 553 GLU C CG  1 
ATOM   969  C CD  . GLU C 2 4  ? -21.805 122.914 -1.547  1.00 58.80 ? 553 GLU C CD  1 
ATOM   970  O OE1 . GLU C 2 4  ? -20.720 122.304 -1.725  1.00 51.48 ? 553 GLU C OE1 1 
ATOM   971  O OE2 . GLU C 2 4  ? -22.358 122.976 -0.420  1.00 62.11 ? 553 GLU C OE2 1 
ATOM   972  N N   . LYS C 2 5  ? -22.000 120.993 -6.536  1.00 55.88 ? 554 LYS C N   1 
ATOM   973  C CA  . LYS C 2 5  ? -21.966 119.826 -7.414  1.00 47.13 ? 554 LYS C CA  1 
ATOM   974  C C   . LYS C 2 5  ? -20.526 119.462 -7.728  1.00 43.28 ? 554 LYS C C   1 
ATOM   975  O O   . LYS C 2 5  ? -20.203 118.286 -7.858  1.00 45.01 ? 554 LYS C O   1 
ATOM   976  C CB  . LYS C 2 5  ? -22.703 120.087 -8.740  1.00 46.50 ? 554 LYS C CB  1 
ATOM   977  C CG  . LYS C 2 5  ? -24.202 119.744 -8.797  1.00 49.13 ? 554 LYS C CG  1 
ATOM   978  C CD  . LYS C 2 5  ? -25.007 120.483 -7.740  1.00 60.65 ? 554 LYS C CD  1 
ATOM   979  C CE  . LYS C 2 5  ? -26.249 119.727 -7.298  1.00 57.14 ? 554 LYS C CE  1 
ATOM   980  N NZ  . LYS C 2 5  ? -26.709 120.235 -5.964  1.00 59.57 ? 554 LYS C NZ  1 
ATOM   981  N N   . LEU C 2 6  ? -19.661 120.465 -7.879  1.00 51.72 ? 555 LEU C N   1 
ATOM   982  C CA  . LEU C 2 6  ? -18.275 120.201 -8.252  1.00 51.15 ? 555 LEU C CA  1 
ATOM   983  C C   . LEU C 2 6  ? -17.560 119.361 -7.194  1.00 47.68 ? 555 LEU C C   1 
ATOM   984  O O   . LEU C 2 6  ? -16.929 118.348 -7.517  1.00 41.55 ? 555 LEU C O   1 
ATOM   985  C CB  . LEU C 2 6  ? -17.541 121.522 -8.498  1.00 54.96 ? 555 LEU C CB  1 
ATOM   986  N N   . HIS C 2 7  ? -17.655 119.756 -5.917  1.00 53.15 ? 556 HIS C N   1 
ATOM   987  C CA  . HIS C 2 7  ? -17.030 118.927 -4.891  1.00 52.88 ? 556 HIS C CA  1 
ATOM   988  C C   . HIS C 2 7  ? -17.860 117.699 -4.554  1.00 46.41 ? 556 HIS C C   1 
ATOM   989  O O   . HIS C 2 7  ? -17.299 116.671 -4.166  1.00 43.36 ? 556 HIS C O   1 
ATOM   990  C CB  . HIS C 2 7  ? -16.762 119.716 -3.614  1.00 60.36 ? 556 HIS C CB  1 
ATOM   991  C CG  . HIS C 2 7  ? -15.351 120.201 -3.518  1.00 65.80 ? 556 HIS C CG  1 
ATOM   992  N ND1 . HIS C 2 7  ? -14.992 121.498 -3.824  1.00 61.73 ? 556 HIS C ND1 1 
ATOM   993  C CD2 . HIS C 2 7  ? -14.194 119.522 -3.304  1.00 50.95 ? 556 HIS C CD2 1 
ATOM   994  C CE1 . HIS C 2 7  ? -13.678 121.618 -3.705  1.00 70.29 ? 556 HIS C CE1 1 
ATOM   995  N NE2 . HIS C 2 7  ? -13.169 120.433 -3.404  1.00 57.01 ? 556 HIS C NE2 1 
ATOM   996  N N   . GLU C 2 8  ? -19.185 117.796 -4.667  1.00 49.68 ? 557 GLU C N   1 
ATOM   997  C CA  . GLU C 2 8  ? -20.030 116.608 -4.624  1.00 42.84 ? 557 GLU C CA  1 
ATOM   998  C C   . GLU C 2 8  ? -19.604 115.608 -5.699  1.00 37.63 ? 557 GLU C C   1 
ATOM   999  O O   . GLU C 2 8  ? -19.352 114.439 -5.397  1.00 44.67 ? 557 GLU C O   1 
ATOM   1000 C CB  . GLU C 2 8  ? -21.498 117.029 -4.778  1.00 53.34 ? 557 GLU C CB  1 
ATOM   1001 C CG  . GLU C 2 8  ? -22.551 115.920 -4.804  1.00 57.51 ? 557 GLU C CG  1 
ATOM   1002 C CD  . GLU C 2 8  ? -23.976 116.428 -4.476  1.00 68.26 ? 557 GLU C CD  1 
ATOM   1003 O OE1 . GLU C 2 8  ? -24.232 117.662 -4.481  1.00 55.86 ? 557 GLU C OE1 1 
ATOM   1004 O OE2 . GLU C 2 8  ? -24.845 115.573 -4.195  1.00 71.34 ? 557 GLU C OE2 1 
ATOM   1005 N N   . ALA C 2 9  ? -19.458 116.070 -6.948  1.00 46.22 ? 558 ALA C N   1 
ATOM   1006 C CA  . ALA C 2 9  ? -19.082 115.182 -8.051  1.00 35.82 ? 558 ALA C CA  1 
ATOM   1007 C C   . ALA C 2 9  ? -17.668 114.641 -7.911  1.00 32.59 ? 558 ALA C C   1 
ATOM   1008 O O   . ALA C 2 9  ? -17.437 113.474 -8.234  1.00 34.27 ? 558 ALA C O   1 
ATOM   1009 C CB  . ALA C 2 9  ? -19.229 115.883 -9.396  1.00 26.66 ? 558 ALA C CB  1 
ATOM   1010 N N   . ASN C 2 10 ? -16.710 115.446 -7.441  1.00 36.14 ? 559 ASN C N   1 
ATOM   1011 C CA  . ASN C 2 10 ? -15.397 114.878 -7.125  1.00 37.78 ? 559 ASN C CA  1 
ATOM   1012 C C   . ASN C 2 10 ? -15.468 113.836 -6.023  1.00 39.16 ? 559 ASN C C   1 
ATOM   1013 O O   . ASN C 2 10 ? -14.712 112.856 -6.061  1.00 42.33 ? 559 ASN C O   1 
ATOM   1014 C CB  . ASN C 2 10 ? -14.371 115.935 -6.714  1.00 45.20 ? 559 ASN C CB  1 
ATOM   1015 C CG  . ASN C 2 10 ? -13.240 115.334 -5.816  1.00 47.25 ? 559 ASN C CG  1 
ATOM   1016 O OD1 . ASN C 2 10 ? -13.437 115.125 -4.610  1.00 43.36 ? 559 ASN C OD1 1 
ATOM   1017 N ND2 . ASN C 2 10 ? -12.104 114.979 -6.421  1.00 46.59 ? 559 ASN C ND2 1 
ATOM   1018 N N   . ASN C 2 11 ? -16.302 114.046 -5.000  1.00 37.20 ? 560 ASN C N   1 
ATOM   1019 C CA  . ASN C 2 11 ? -16.401 113.015 -3.969  1.00 38.38 ? 560 ASN C CA  1 
ATOM   1020 C C   . ASN C 2 11 ? -16.958 111.717 -4.549  1.00 38.87 ? 560 ASN C C   1 
ATOM   1021 O O   . ASN C 2 11 ? -16.362 110.645 -4.377  1.00 35.99 ? 560 ASN C O   1 
ATOM   1022 C CB  . ASN C 2 11 ? -17.236 113.501 -2.793  1.00 34.70 ? 560 ASN C CB  1 
ATOM   1023 C CG  . ASN C 2 11 ? -16.371 114.090 -1.706  1.00 43.47 ? 560 ASN C CG  1 
ATOM   1024 O OD1 . ASN C 2 11 ? -15.590 113.365 -1.085  1.00 43.76 ? 560 ASN C OD1 1 
ATOM   1025 N ND2 . ASN C 2 11 ? -16.486 115.410 -1.471  1.00 44.53 ? 560 ASN C ND2 1 
ATOM   1026 N N   . GLU C 2 12 ? -18.072 111.804 -5.290  1.00 34.22 ? 561 GLU C N   1 
ATOM   1027 C CA  . GLU C 2 12 ? -18.615 110.613 -5.933  1.00 37.37 ? 561 GLU C CA  1 
ATOM   1028 C C   . GLU C 2 12 ? -17.634 110.011 -6.921  1.00 37.13 ? 561 GLU C C   1 
ATOM   1029 O O   . GLU C 2 12 ? -17.577 108.789 -7.076  1.00 38.83 ? 561 GLU C O   1 
ATOM   1030 C CB  . GLU C 2 12 ? -19.913 110.924 -6.670  1.00 43.36 ? 561 GLU C CB  1 
ATOM   1031 C CG  . GLU C 2 12 ? -20.551 109.666 -7.259  1.00 43.98 ? 561 GLU C CG  1 
ATOM   1032 C CD  . GLU C 2 12 ? -22.050 109.674 -7.144  1.00 58.19 ? 561 GLU C CD  1 
ATOM   1033 O OE1 . GLU C 2 12 ? -22.716 108.851 -7.813  1.00 55.41 ? 561 GLU C OE1 1 
ATOM   1034 O OE2 . GLU C 2 12 ? -22.563 110.553 -6.416  1.00 77.91 ? 561 GLU C OE2 1 
ATOM   1035 N N   . LEU C 2 13 ? -16.882 110.851 -7.624  1.00 38.95 ? 562 LEU C N   1 
ATOM   1036 C CA  . LEU C 2 13 ? -15.872 110.352 -8.551  1.00 35.02 ? 562 LEU C CA  1 
ATOM   1037 C C   . LEU C 2 13 ? -14.901 109.408 -7.856  1.00 34.40 ? 562 LEU C C   1 
ATOM   1038 O O   . LEU C 2 13 ? -14.613 108.320 -8.354  1.00 37.73 ? 562 LEU C O   1 
ATOM   1039 C CB  . LEU C 2 13 ? -15.110 111.526 -9.167  1.00 36.13 ? 562 LEU C CB  1 
ATOM   1040 C CG  . LEU C 2 13 ? -15.158 111.761 -10.675 1.00 36.67 ? 562 LEU C CG  1 
ATOM   1041 C CD1 . LEU C 2 13 ? -14.128 112.808 -11.049 1.00 42.48 ? 562 LEU C CD1 1 
ATOM   1042 C CD2 . LEU C 2 13 ? -14.912 110.484 -11.469 1.00 36.71 ? 562 LEU C CD2 1 
ATOM   1043 N N   . GLN C 2 14 ? -14.351 109.829 -6.720  1.00 36.64 ? 563 GLN C N   1 
ATOM   1044 C CA  . GLN C 2 14 ? -13.272 109.080 -6.097  1.00 33.74 ? 563 GLN C CA  1 
ATOM   1045 C C   . GLN C 2 14 ? -13.794 107.892 -5.339  1.00 34.20 ? 563 GLN C C   1 
ATOM   1046 O O   . GLN C 2 14 ? -13.035 106.959 -5.080  1.00 35.88 ? 563 GLN C O   1 
ATOM   1047 C CB  . GLN C 2 14 ? -12.466 109.986 -5.164  1.00 38.58 ? 563 GLN C CB  1 
ATOM   1048 C CG  . GLN C 2 14 ? -13.188 110.356 -3.874  1.00 46.72 ? 563 GLN C CG  1 
ATOM   1049 C CD  . GLN C 2 14 ? -12.234 110.735 -2.755  1.00 51.30 ? 563 GLN C CD  1 
ATOM   1050 O OE1 . GLN C 2 14 ? -11.100 111.171 -3.009  1.00 47.35 ? 563 GLN C OE1 1 
ATOM   1051 N NE2 . GLN C 2 14 ? -12.680 110.547 -1.503  1.00 44.75 ? 563 GLN C NE2 1 
ATOM   1052 N N   . LYS C 2 15 ? -15.075 107.919 -4.992  1.00 36.60 ? 564 LYS C N   1 
ATOM   1053 C CA  . LYS C 2 15 ? -15.714 106.762 -4.387  1.00 35.11 ? 564 LYS C CA  1 
ATOM   1054 C C   . LYS C 2 15 ? -15.908 105.671 -5.428  1.00 36.64 ? 564 LYS C C   1 
ATOM   1055 O O   . LYS C 2 15 ? -15.629 104.489 -5.166  1.00 37.61 ? 564 LYS C O   1 
ATOM   1056 C CB  . LYS C 2 15 ? -17.053 107.187 -3.793  1.00 37.72 ? 564 LYS C CB  1 
ATOM   1057 C CG  . LYS C 2 15 ? -16.920 108.124 -2.599  1.00 45.62 ? 564 LYS C CG  1 
ATOM   1058 N N   . LYS C 2 16 ? -16.356 106.055 -6.625  1.00 33.59 ? 565 LYS C N   1 
ATOM   1059 C CA  . LYS C 2 16 ? -16.618 105.096 -7.682  1.00 34.55 ? 565 LYS C CA  1 
ATOM   1060 C C   . LYS C 2 16 ? -15.343 104.521 -8.294  1.00 34.73 ? 565 LYS C C   1 
ATOM   1061 O O   . LYS C 2 16 ? -15.367 103.391 -8.796  1.00 40.34 ? 565 LYS C O   1 
ATOM   1062 C CB  . LYS C 2 16 ? -17.512 105.730 -8.751  1.00 26.31 ? 565 LYS C CB  1 
ATOM   1063 C CG  . LYS C 2 16 ? -18.962 105.324 -8.570  1.00 23.90 ? 565 LYS C CG  1 
ATOM   1064 C CD  . LYS C 2 16 ? -19.916 106.440 -8.866  1.00 36.88 ? 565 LYS C CD  1 
ATOM   1065 C CE  . LYS C 2 16 ? -21.285 106.217 -8.218  1.00 44.42 ? 565 LYS C CE  1 
ATOM   1066 N NZ  . LYS C 2 16 ? -22.176 105.289 -8.954  1.00 42.82 ? 565 LYS C NZ  1 
ATOM   1067 N N   . ARG C 2 17 ? -14.219 105.216 -8.240  1.00 30.62 ? 566 ARG C N   1 
ATOM   1068 C CA  . ARG C 2 17 ? -13.010 104.545 -8.699  1.00 33.67 ? 566 ARG C CA  1 
ATOM   1069 C C   . ARG C 2 17 ? -12.372 103.686 -7.608  1.00 40.84 ? 566 ARG C C   1 
ATOM   1070 O O   . ARG C 2 17 ? -11.616 102.760 -7.922  1.00 40.54 ? 566 ARG C O   1 
ATOM   1071 C CB  . ARG C 2 17 ? -12.008 105.561 -9.255  1.00 34.58 ? 566 ARG C CB  1 
ATOM   1072 C CG  . ARG C 2 17 ? -11.456 106.535 -8.231  1.00 45.96 ? 566 ARG C CG  1 
ATOM   1073 C CD  . ARG C 2 17 ? -11.182 107.916 -8.855  1.00 57.88 ? 566 ARG C CD  1 
ATOM   1074 N NE  . ARG C 2 17 ? -9.793  108.144 -9.257  1.00 60.72 ? 566 ARG C NE  1 
ATOM   1075 C CZ  . ARG C 2 17 ? -9.380  109.255 -9.860  1.00 58.11 ? 566 ARG C CZ  1 
ATOM   1076 N NH1 . ARG C 2 17 ? -10.256 110.222 -10.112 1.00 53.81 ? 566 ARG C NH1 1 
ATOM   1077 N NH2 . ARG C 2 17 ? -8.103  109.401 -10.206 1.00 59.44 ? 566 ARG C NH2 1 
ATOM   1078 N N   . ALA C 2 18 ? -12.667 103.947 -6.332  1.00 39.63 ? 567 ALA C N   1 
ATOM   1079 C CA  . ALA C 2 18 ? -12.241 103.017 -5.299  1.00 34.85 ? 567 ALA C CA  1 
ATOM   1080 C C   . ALA C 2 18 ? -12.916 101.674 -5.498  1.00 40.03 ? 567 ALA C C   1 
ATOM   1081 O O   . ALA C 2 18 ? -12.376 100.635 -5.105  1.00 45.05 ? 567 ALA C O   1 
ATOM   1082 C CB  . ALA C 2 18 ? -12.552 103.592 -3.914  1.00 33.94 ? 567 ALA C CB  1 
ATOM   1083 N N   . ILE C 2 19 ? -14.088 101.679 -6.131  1.00 38.67 ? 568 ILE C N   1 
ATOM   1084 C CA  . ILE C 2 19 ? -14.818 100.441 -6.377  1.00 38.67 ? 568 ILE C CA  1 
ATOM   1085 C C   . ILE C 2 19 ? -14.175 99.670  -7.526  1.00 41.06 ? 568 ILE C C   1 
ATOM   1086 O O   . ILE C 2 19 ? -13.805 98.500  -7.377  1.00 44.31 ? 568 ILE C O   1 
ATOM   1087 C CB  . ILE C 2 19 ? -16.302 100.742 -6.648  1.00 33.95 ? 568 ILE C CB  1 
ATOM   1088 C CG1 . ILE C 2 19 ? -16.998 101.097 -5.341  1.00 35.04 ? 568 ILE C CG1 1 
ATOM   1089 C CG2 . ILE C 2 19 ? -16.983 99.557  -7.265  1.00 36.20 ? 568 ILE C CG2 1 
ATOM   1090 C CD1 . ILE C 2 19 ? -18.394 101.611 -5.519  1.00 36.01 ? 568 ILE C CD1 1 
ATOM   1091 N N   . ILE C 2 20 ? -14.007 100.330 -8.673  1.00 41.12 ? 569 ILE C N   1 
ATOM   1092 C CA  . ILE C 2 20 ? -13.360 99.704  -9.823  1.00 37.51 ? 569 ILE C CA  1 
ATOM   1093 C C   . ILE C 2 20 ? -11.876 99.463  -9.603  1.00 41.03 ? 569 ILE C C   1 
ATOM   1094 O O   . ILE C 2 20 ? -11.254 98.741  -10.384 1.00 47.08 ? 569 ILE C O   1 
ATOM   1095 C CB  . ILE C 2 20 ? -13.581 100.557 -11.087 1.00 36.73 ? 569 ILE C CB  1 
ATOM   1096 C CG1 . ILE C 2 20 ? -15.036 101.010 -11.160 1.00 39.52 ? 569 ILE C CG1 1 
ATOM   1097 C CG2 . ILE C 2 20 ? -13.288 99.749  -12.334 1.00 43.08 ? 569 ILE C CG2 1 
ATOM   1098 C CD1 . ILE C 2 20 ? -15.249 102.300 -11.891 1.00 32.01 ? 569 ILE C CD1 1 
ATOM   1099 N N   . GLU C 2 21 ? -11.277 100.046 -8.571  1.00 43.13 ? 570 GLU C N   1 
ATOM   1100 C CA  . GLU C 2 21 ? -9.932  99.656  -8.177  1.00 43.26 ? 570 GLU C CA  1 
ATOM   1101 C C   . GLU C 2 21 ? -9.950  98.542  -7.153  1.00 42.57 ? 570 GLU C C   1 
ATOM   1102 O O   . GLU C 2 21 ? -8.896  97.978  -6.845  1.00 43.54 ? 570 GLU C O   1 
ATOM   1103 C CB  . GLU C 2 21 ? -9.142  100.855 -7.635  1.00 51.52 ? 570 GLU C CB  1 
ATOM   1104 C CG  . GLU C 2 21 ? -7.785  101.027 -8.331  1.00 55.92 ? 570 GLU C CG  1 
ATOM   1105 C CD  . GLU C 2 21 ? -6.957  102.210 -7.826  1.00 56.98 ? 570 GLU C CD  1 
ATOM   1106 O OE1 . GLU C 2 21 ? -7.417  102.953 -6.926  1.00 55.04 ? 570 GLU C OE1 1 
ATOM   1107 O OE2 . GLU C 2 21 ? -5.842  102.391 -8.358  1.00 57.23 ? 570 GLU C OE2 1 
ATOM   1108 N N   . ASP C 2 22 ? -11.125 98.235  -6.608  1.00 44.31 ? 571 ASP C N   1 
ATOM   1109 C CA  . ASP C 2 22 ? -11.337 97.040  -5.808  1.00 44.02 ? 571 ASP C CA  1 
ATOM   1110 C C   . ASP C 2 22 ? -11.754 95.847  -6.661  1.00 41.09 ? 571 ASP C C   1 
ATOM   1111 O O   . ASP C 2 22 ? -11.230 94.752  -6.467  1.00 44.35 ? 571 ASP C O   1 
ATOM   1112 C CB  . ASP C 2 22 ? -12.396 97.318  -4.735  1.00 46.53 ? 571 ASP C CB  1 
ATOM   1113 C CG  . ASP C 2 22 ? -12.481 96.220  -3.689  1.00 50.27 ? 571 ASP C CG  1 
ATOM   1114 O OD1 . ASP C 2 22 ? -13.366 95.348  -3.812  1.00 64.69 ? 571 ASP C OD1 1 
ATOM   1115 O OD2 . ASP C 2 22 ? -11.669 96.225  -2.739  1.00 49.18 ? 571 ASP C OD2 1 
ATOM   1116 N N   . LEU C 2 23 ? -12.644 96.040  -7.633  1.00 41.17 ? 572 LEU C N   1 
ATOM   1117 C CA  . LEU C 2 23 ? -13.229 94.940  -8.397  1.00 43.11 ? 572 LEU C CA  1 
ATOM   1118 C C   . LEU C 2 23 ? -12.271 94.297  -9.396  1.00 45.25 ? 572 LEU C C   1 
ATOM   1119 O O   . LEU C 2 23 ? -12.258 93.069  -9.522  1.00 45.68 ? 572 LEU C O   1 
ATOM   1120 C CB  . LEU C 2 23 ? -14.471 95.428  -9.143  1.00 47.35 ? 572 LEU C CB  1 
ATOM   1121 C CG  . LEU C 2 23 ? -15.796 94.908  -8.597  1.00 46.32 ? 572 LEU C CG  1 
ATOM   1122 C CD1 . LEU C 2 23 ? -16.945 95.137  -9.579  1.00 43.47 ? 572 LEU C CD1 1 
ATOM   1123 C CD2 . LEU C 2 23 ? -15.665 93.437  -8.234  1.00 51.23 ? 572 LEU C CD2 1 
ATOM   1124 N N   . GLU C 2 24 ? -11.495 95.089  -10.138 1.00 46.50 ? 573 GLU C N   1 
ATOM   1125 C CA  . GLU C 2 24 ? -10.577 94.528  -11.120 1.00 48.95 ? 573 GLU C CA  1 
ATOM   1126 C C   . GLU C 2 24 ? -9.647  93.430  -10.584 1.00 46.51 ? 573 GLU C C   1 
ATOM   1127 O O   . GLU C 2 24 ? -9.488  92.424  -11.275 1.00 51.06 ? 573 GLU C O   1 
ATOM   1128 C CB  . GLU C 2 24 ? -9.768  95.645  -11.803 1.00 49.57 ? 573 GLU C CB  1 
ATOM   1129 C CG  . GLU C 2 24 ? -10.521 96.357  -12.939 1.00 50.27 ? 573 GLU C CG  1 
ATOM   1130 C CD  . GLU C 2 24 ? -9.730  97.496  -13.589 1.00 71.77 ? 573 GLU C CD  1 
ATOM   1131 O OE1 . GLU C 2 24 ? -8.932  98.180  -12.898 1.00 71.26 ? 573 GLU C OE1 1 
ATOM   1132 O OE2 . GLU C 2 24 ? -9.856  97.656  -14.826 1.00 79.56 ? 573 GLU C OE2 1 
ATOM   1133 N N   . PRO C 2 25 ? -9.027  93.561  -9.399  1.00 45.23 ? 574 PRO C N   1 
ATOM   1134 C CA  . PRO C 2 25 ? -8.160  92.459  -8.939  1.00 48.06 ? 574 PRO C CA  1 
ATOM   1135 C C   . PRO C 2 25 ? -8.945  91.358  -8.252  1.00 52.22 ? 574 PRO C C   1 
ATOM   1136 O O   . PRO C 2 25 ? -8.493  90.206  -8.212  1.00 56.76 ? 574 PRO C O   1 
ATOM   1137 C CB  . PRO C 2 25 ? -7.204  93.153  -7.961  1.00 45.24 ? 574 PRO C CB  1 
ATOM   1138 C CG  . PRO C 2 25 ? -8.044  94.217  -7.367  1.00 49.90 ? 574 PRO C CG  1 
ATOM   1139 C CD  . PRO C 2 25 ? -8.944  94.715  -8.494  1.00 49.14 ? 574 PRO C CD  1 
ATOM   1140 N N   . ARG C 2 26 ? -10.111 91.702  -7.697  1.00 48.25 ? 575 ARG C N   1 
ATOM   1141 C CA  . ARG C 2 26 ? -10.970 90.678  -7.105  1.00 48.23 ? 575 ARG C CA  1 
ATOM   1142 C C   . ARG C 2 26 ? -11.475 89.728  -8.182  1.00 52.56 ? 575 ARG C C   1 
ATOM   1143 O O   . ARG C 2 26 ? -11.489 88.501  -7.991  1.00 54.60 ? 575 ARG C O   1 
ATOM   1144 C CB  . ARG C 2 26 ? -12.126 91.336  -6.355  1.00 42.82 ? 575 ARG C CB  1 
ATOM   1145 C CG  . ARG C 2 26 ? -11.647 92.105  -5.140  1.00 48.98 ? 575 ARG C CG  1 
ATOM   1146 C CD  . ARG C 2 26 ? -12.378 91.740  -3.864  1.00 59.49 ? 575 ARG C CD  1 
ATOM   1147 N NE  . ARG C 2 26 ? -11.485 91.868  -2.715  1.00 57.31 ? 575 ARG C NE  1 
ATOM   1148 C CZ  . ARG C 2 26 ? -11.845 91.666  -1.452  1.00 71.21 ? 575 ARG C CZ  1 
ATOM   1149 N NH1 . ARG C 2 26 ? -13.091 91.305  -1.166  1.00 87.20 ? 575 ARG C NH1 1 
ATOM   1150 N NH2 . ARG C 2 26 ? -10.956 91.814  -0.470  1.00 71.36 ? 575 ARG C NH2 1 
ATOM   1151 N N   . PHE C 2 27 ? -11.861 90.269  -9.338  1.00 51.85 ? 576 PHE C N   1 
ATOM   1152 C CA  . PHE C 2 27 ? -12.260 89.434  -10.464 1.00 52.48 ? 576 PHE C CA  1 
ATOM   1153 C C   . PHE C 2 27 ? -11.064 88.718  -11.080 1.00 47.50 ? 576 PHE C C   1 
ATOM   1154 O O   . PHE C 2 27 ? -11.137 87.528  -11.387 1.00 49.82 ? 576 PHE C O   1 
ATOM   1155 C CB  . PHE C 2 27 ? -12.975 90.278  -11.527 1.00 47.18 ? 576 PHE C CB  1 
ATOM   1156 C CG  . PHE C 2 27 ? -13.195 89.551  -12.814 1.00 53.45 ? 576 PHE C CG  1 
ATOM   1157 C CD1 . PHE C 2 27 ? -14.265 88.675  -12.961 1.00 51.78 ? 576 PHE C CD1 1 
ATOM   1158 C CD2 . PHE C 2 27 ? -12.300 89.694  -13.868 1.00 59.51 ? 576 PHE C CD2 1 
ATOM   1159 C CE1 . PHE C 2 27 ? -14.452 87.981  -14.148 1.00 51.44 ? 576 PHE C CE1 1 
ATOM   1160 C CE2 . PHE C 2 27 ? -12.481 88.996  -15.060 1.00 58.60 ? 576 PHE C CE2 1 
ATOM   1161 C CZ  . PHE C 2 27 ? -13.556 88.141  -15.197 1.00 54.66 ? 576 PHE C CZ  1 
ATOM   1162 N N   . ASN C 2 28 ? -9.967  89.445  -11.297 1.00 47.55 ? 577 ASN C N   1 
ATOM   1163 C CA  . ASN C 2 28 ? -8.787  88.862  -11.920 1.00 48.56 ? 577 ASN C CA  1 
ATOM   1164 C C   . ASN C 2 28 ? -8.319  87.629  -11.164 1.00 54.50 ? 577 ASN C C   1 
ATOM   1165 O O   . ASN C 2 28 ? -7.930  86.623  -11.775 1.00 52.40 ? 577 ASN C O   1 
ATOM   1166 C CB  . ASN C 2 28 ? -7.678  89.910  -11.979 1.00 48.87 ? 577 ASN C CB  1 
ATOM   1167 C CG  . ASN C 2 28 ? -6.421  89.387  -12.633 1.00 57.14 ? 577 ASN C CG  1 
ATOM   1168 O OD1 . ASN C 2 28 ? -6.490  88.716  -13.665 1.00 67.81 ? 577 ASN C OD1 1 
ATOM   1169 N ND2 . ASN C 2 28 ? -5.258  89.694  -12.042 1.00 54.39 ? 577 ASN C ND2 1 
ATOM   1170 N N   . ASN C 2 29 ? -8.367  87.679  -9.835  1.00 53.49 ? 578 ASN C N   1 
ATOM   1171 C CA  . ASN C 2 29 ? -7.872  86.558  -9.045  1.00 59.47 ? 578 ASN C CA  1 
ATOM   1172 C C   . ASN C 2 29 ? -8.833  85.371  -9.111  1.00 56.91 ? 578 ASN C C   1 
ATOM   1173 O O   . ASN C 2 29 ? -8.405  84.212  -9.164  1.00 52.90 ? 578 ASN C O   1 
ATOM   1174 C CB  . ASN C 2 29 ? -7.653  87.005  -7.600  1.00 62.01 ? 578 ASN C CB  1 
ATOM   1175 C CG  . ASN C 2 29 ? -6.281  87.625  -7.387  1.00 68.54 ? 578 ASN C CG  1 
ATOM   1176 O OD1 . ASN C 2 29 ? -5.358  87.439  -8.193  1.00 64.47 ? 578 ASN C OD1 1 
ATOM   1177 N ND2 . ASN C 2 29 ? -6.141  88.369  -6.297  1.00 82.45 ? 578 ASN C ND2 1 
ATOM   1178 N N   . SER C 2 30 ? -10.134 85.647  -9.102  1.00 57.10 ? 579 SER C N   1 
ATOM   1179 C CA  . SER C 2 30 ? -11.110 84.581  -9.270  1.00 53.37 ? 579 SER C CA  1 
ATOM   1180 C C   . SER C 2 30 ? -10.965 83.924  -10.637 1.00 52.90 ? 579 SER C C   1 
ATOM   1181 O O   . SER C 2 30 ? -10.964 82.693  -10.736 1.00 58.18 ? 579 SER C O   1 
ATOM   1182 C CB  . SER C 2 30 ? -12.518 85.140  -9.064  1.00 53.28 ? 579 SER C CB  1 
ATOM   1183 O OG  . SER C 2 30 ? -13.509 84.163  -9.303  1.00 57.65 ? 579 SER C OG  1 
ATOM   1184 N N   . SER C 2 31 ? -10.805 84.719  -11.702 1.00 53.97 ? 580 SER C N   1 
ATOM   1185 C CA  . SER C 2 31 ? -10.551 84.155  -13.027 1.00 52.09 ? 580 SER C CA  1 
ATOM   1186 C C   . SER C 2 31 ? -9.357  83.211  -13.027 1.00 54.28 ? 580 SER C C   1 
ATOM   1187 O O   . SER C 2 31 ? -9.237  82.371  -13.923 1.00 52.79 ? 580 SER C O   1 
ATOM   1188 C CB  . SER C 2 31 ? -10.314 85.257  -14.066 1.00 55.34 ? 580 SER C CB  1 
ATOM   1189 O OG  . SER C 2 31 ? -11.523 85.850  -14.516 1.00 59.22 ? 580 SER C OG  1 
ATOM   1190 N N   . LEU C 2 32 ? -8.446  83.366  -12.068 1.00 61.52 ? 581 LEU C N   1 
ATOM   1191 C CA  . LEU C 2 32 ? -7.479  82.316  -11.778 1.00 57.60 ? 581 LEU C CA  1 
ATOM   1192 C C   . LEU C 2 32 ? -8.113  81.157  -11.030 1.00 54.46 ? 581 LEU C C   1 
ATOM   1193 O O   . LEU C 2 32 ? -7.859  79.999  -11.369 1.00 57.68 ? 581 LEU C O   1 
ATOM   1194 C CB  . LEU C 2 32 ? -6.285  82.895  -11.009 1.00 62.16 ? 581 LEU C CB  1 
ATOM   1195 C CG  . LEU C 2 32 ? -5.090  82.061  -10.624 1.00 75.01 ? 581 LEU C CG  1 
ATOM   1196 C CD1 . LEU C 2 32 ? -5.297  81.467  -9.291  1.00 70.32 ? 581 LEU C CD1 1 
ATOM   1197 C CD2 . LEU C 2 32 ? -4.837  80.898  -11.590 1.00 55.47 ? 581 LEU C CD2 1 
ATOM   1198 N N   . LYS C 2 33 ? -8.940  81.436  -10.022 1.00 52.16 ? 582 LYS C N   1 
ATOM   1199 C CA  . LYS C 2 33 ? -9.504  80.348  -9.229  1.00 55.37 ? 582 LYS C CA  1 
ATOM   1200 C C   . LYS C 2 33 ? -10.354 79.421  -10.091 1.00 59.45 ? 582 LYS C C   1 
ATOM   1201 O O   . LYS C 2 33 ? -10.195 78.193  -10.035 1.00 61.49 ? 582 LYS C O   1 
ATOM   1202 C CB  . LYS C 2 33 ? -10.324 80.894  -8.060  1.00 54.09 ? 582 LYS C CB  1 
ATOM   1203 C CG  . LYS C 2 33 ? -10.717 79.823  -7.036  1.00 54.42 ? 582 LYS C CG  1 
ATOM   1204 C CD  . LYS C 2 33 ? -11.236 80.437  -5.749  1.00 50.57 ? 582 LYS C CD  1 
ATOM   1205 C CE  . LYS C 2 33 ? -11.454 79.403  -4.663  1.00 52.42 ? 582 LYS C CE  1 
ATOM   1206 N NZ  . LYS C 2 33 ? -11.747 80.046  -3.350  1.00 61.84 ? 582 LYS C NZ  1 
ATOM   1207 N N   . ILE C 2 34 ? -11.259 79.982  -10.902 1.00 54.84 ? 583 ILE C N   1 
ATOM   1208 C CA  . ILE C 2 34 ? -12.126 79.131  -11.718 1.00 56.70 ? 583 ILE C CA  1 
ATOM   1209 C C   . ILE C 2 34 ? -11.292 78.221  -12.611 1.00 55.10 ? 583 ILE C C   1 
ATOM   1210 O O   . ILE C 2 34 ? -11.479 76.996  -12.623 1.00 52.19 ? 583 ILE C O   1 
ATOM   1211 C CB  . ILE C 2 34 ? -13.131 79.976  -12.524 1.00 52.87 ? 583 ILE C CB  1 
ATOM   1212 C CG1 . ILE C 2 34 ? -12.456 81.210  -13.134 1.00 61.82 ? 583 ILE C CG1 1 
ATOM   1213 C CG2 . ILE C 2 34 ? -14.332 80.338  -11.663 1.00 51.82 ? 583 ILE C CG2 1 
ATOM   1214 C CD1 . ILE C 2 34 ? -13.419 82.161  -13.876 1.00 63.68 ? 583 ILE C CD1 1 
ATOM   1215 N N   . GLU C 2 35 ? -10.321 78.795  -13.326 1.00 51.80 ? 584 GLU C N   1 
ATOM   1216 C CA  . GLU C 2 35 ? -9.462  77.979  -14.175 1.00 51.98 ? 584 GLU C CA  1 
ATOM   1217 C C   . GLU C 2 35 ? -8.589  77.044  -13.351 1.00 57.14 ? 584 GLU C C   1 
ATOM   1218 O O   . GLU C 2 35 ? -8.294  75.921  -13.790 1.00 54.06 ? 584 GLU C O   1 
ATOM   1219 C CB  . GLU C 2 35 ? -8.606  78.864  -15.061 1.00 49.65 ? 584 GLU C CB  1 
ATOM   1220 C CG  . GLU C 2 35 ? -9.407  79.512  -16.149 1.00 62.68 ? 584 GLU C CG  1 
ATOM   1221 C CD  . GLU C 2 35 ? -8.529  80.057  -17.245 1.00 76.49 ? 584 GLU C CD  1 
ATOM   1222 O OE1 . GLU C 2 35 ? -7.300  80.135  -17.030 1.00 77.51 ? 584 GLU C OE1 1 
ATOM   1223 O OE2 . GLU C 2 35 ? -9.063  80.394  -18.325 1.00 82.76 ? 584 GLU C OE2 1 
ATOM   1224 N N   . GLU C 2 36 ? -8.149  77.487  -12.174 1.00 58.58 ? 585 GLU C N   1 
ATOM   1225 C CA  . GLU C 2 36 ? -7.460  76.585  -11.258 1.00 55.74 ? 585 GLU C CA  1 
ATOM   1226 C C   . GLU C 2 36 ? -8.350  75.398  -10.925 1.00 55.40 ? 585 GLU C C   1 
ATOM   1227 O O   . GLU C 2 36 ? -7.971  74.238  -11.119 1.00 55.11 ? 585 GLU C O   1 
ATOM   1228 C CB  . GLU C 2 36 ? -7.063  77.322  -9.979  1.00 58.00 ? 585 GLU C CB  1 
ATOM   1229 C CG  . GLU C 2 36 ? -5.607  77.175  -9.600  1.00 64.80 ? 585 GLU C CG  1 
ATOM   1230 C CD  . GLU C 2 36 ? -5.209  78.120  -8.486  1.00 71.39 ? 585 GLU C CD  1 
ATOM   1231 O OE1 . GLU C 2 36 ? -6.121  78.716  -7.866  1.00 73.40 ? 585 GLU C OE1 1 
ATOM   1232 O OE2 . GLU C 2 36 ? -3.994  78.250  -8.220  1.00 82.30 ? 585 GLU C OE2 1 
ATOM   1233 N N   . LEU C 2 37 ? -9.563  75.684  -10.440 1.00 54.00 ? 586 LEU C N   1 
ATOM   1234 C CA  . LEU C 2 37 ? -10.512 74.625  -10.126 1.00 53.31 ? 586 LEU C CA  1 
ATOM   1235 C C   . LEU C 2 37 ? -10.839 73.788  -11.355 1.00 51.60 ? 586 LEU C C   1 
ATOM   1236 O O   . LEU C 2 37 ? -11.091 72.586  -11.245 1.00 41.51 ? 586 LEU C O   1 
ATOM   1237 C CB  . LEU C 2 37 ? -11.794 75.222  -9.547  1.00 49.33 ? 586 LEU C CB  1 
ATOM   1238 C CG  . LEU C 2 37 ? -11.767 75.632  -8.068  1.00 50.13 ? 586 LEU C CG  1 
ATOM   1239 C CD1 . LEU C 2 37 ? -12.806 76.719  -7.821  1.00 56.23 ? 586 LEU C CD1 1 
ATOM   1240 C CD2 . LEU C 2 37 ? -11.942 74.477  -7.095  1.00 43.76 ? 586 LEU C CD2 1 
ATOM   1241 N N   . GLN C 2 38 ? -10.832 74.402  -12.539 1.00 53.29 ? 587 GLN C N   1 
ATOM   1242 C CA  . GLN C 2 38 ? -11.206 73.650  -13.724 1.00 50.03 ? 587 GLN C CA  1 
ATOM   1243 C C   . GLN C 2 38 ? -10.140 72.635  -14.098 1.00 51.43 ? 587 GLN C C   1 
ATOM   1244 O O   . GLN C 2 38 ? -10.475 71.553  -14.586 1.00 52.77 ? 587 GLN C O   1 
ATOM   1245 C CB  . GLN C 2 38 ? -11.475 74.581  -14.900 1.00 55.37 ? 587 GLN C CB  1 
ATOM   1246 C CG  . GLN C 2 38 ? -12.749 74.214  -15.639 1.00 59.77 ? 587 GLN C CG  1 
ATOM   1247 C CD  . GLN C 2 38 ? -13.407 75.407  -16.316 1.00 69.59 ? 587 GLN C CD  1 
ATOM   1248 O OE1 . GLN C 2 38 ? -12.843 76.503  -16.360 1.00 61.81 ? 587 GLN C OE1 1 
ATOM   1249 N NE2 . GLN C 2 38 ? -14.609 75.196  -16.852 1.00 77.04 ? 587 GLN C NE2 1 
ATOM   1250 N N   . GLU C 2 39 ? -8.863  72.945  -13.871 1.00 48.49 ? 588 GLU C N   1 
ATOM   1251 C CA  . GLU C 2 39 ? -7.823  71.988  -14.235 1.00 47.93 ? 588 GLU C CA  1 
ATOM   1252 C C   . GLU C 2 39 ? -7.699  70.852  -13.239 1.00 47.12 ? 588 GLU C C   1 
ATOM   1253 O O   . GLU C 2 39 ? -7.293  69.748  -13.607 1.00 47.58 ? 588 GLU C O   1 
ATOM   1254 C CB  . GLU C 2 39 ? -6.464  72.662  -14.389 1.00 57.31 ? 588 GLU C CB  1 
ATOM   1255 C CG  . GLU C 2 39 ? -5.498  71.772  -15.133 1.00 52.40 ? 588 GLU C CG  1 
ATOM   1256 C CD  . GLU C 2 39 ? -5.955  71.500  -16.566 1.00 67.26 ? 588 GLU C CD  1 
ATOM   1257 O OE1 . GLU C 2 39 ? -6.891  72.190  -17.047 1.00 62.39 ? 588 GLU C OE1 1 
ATOM   1258 O OE2 . GLU C 2 39 ? -5.421  70.551  -17.190 1.00 61.02 ? 588 GLU C OE2 1 
ATOM   1259 N N   . ALA C 2 40 ? -8.043  71.083  -11.983 1.00 48.25 ? 589 ALA C N   1 
ATOM   1260 C CA  . ALA C 2 40 ? -8.012  69.978  -11.036 1.00 44.58 ? 589 ALA C CA  1 
ATOM   1261 C C   . ALA C 2 40 ? -9.092  68.959  -11.349 1.00 39.67 ? 589 ALA C C   1 
ATOM   1262 O O   . ALA C 2 40 ? -8.879  67.769  -11.137 1.00 40.19 ? 589 ALA C O   1 
ATOM   1263 C CB  . ALA C 2 40 ? -8.161  70.496  -9.607  1.00 47.89 ? 589 ALA C CB  1 
ATOM   1264 N N   . LEU C 2 41 ? -10.244 69.404  -11.862 1.00 43.03 ? 590 LEU C N   1 
ATOM   1265 C CA  . LEU C 2 41 ? -11.283 68.478  -12.310 1.00 41.57 ? 590 LEU C CA  1 
ATOM   1266 C C   . LEU C 2 41 ? -10.761 67.535  -13.385 1.00 41.68 ? 590 LEU C C   1 
ATOM   1267 O O   . LEU C 2 41 ? -10.920 66.309  -13.281 1.00 35.32 ? 590 LEU C O   1 
ATOM   1268 C CB  . LEU C 2 41 ? -12.476 69.247  -12.857 1.00 33.30 ? 590 LEU C CB  1 
ATOM   1269 C CG  . LEU C 2 41 ? -13.441 69.655  -11.758 1.00 36.37 ? 590 LEU C CG  1 
ATOM   1270 C CD1 . LEU C 2 41 ? -14.725 70.125  -12.383 1.00 37.65 ? 590 LEU C CD1 1 
ATOM   1271 C CD2 . LEU C 2 41 ? -13.678 68.506  -10.848 1.00 37.76 ? 590 LEU C CD2 1 
ATOM   1272 N N   . ARG C 2 42 ? -10.185 68.106  -14.441 1.00 39.88 ? 591 ARG C N   1 
ATOM   1273 C CA  . ARG C 2 42 ? -9.594  67.290  -15.488 1.00 41.70 ? 591 ARG C CA  1 
ATOM   1274 C C   . ARG C 2 42 ? -8.535  66.370  -14.914 1.00 40.81 ? 591 ARG C C   1 
ATOM   1275 O O   . ARG C 2 42 ? -8.437  65.197  -15.281 1.00 40.70 ? 591 ARG C O   1 
ATOM   1276 C CB  . ARG C 2 42 ? -9.012  68.194  -16.566 1.00 44.87 ? 591 ARG C CB  1 
ATOM   1277 C CG  . ARG C 2 42 ? -8.897  67.527  -17.922 1.00 62.29 ? 591 ARG C CG  1 
ATOM   1278 C CD  . ARG C 2 42 ? -7.496  66.913  -18.161 1.00 65.89 ? 591 ARG C CD  1 
ATOM   1279 N NE  . ARG C 2 42 ? -6.403  67.857  -17.888 1.00 69.71 ? 591 ARG C NE  1 
ATOM   1280 C CZ  . ARG C 2 42 ? -5.351  67.619  -17.095 1.00 66.23 ? 591 ARG C CZ  1 
ATOM   1281 N NH1 . ARG C 2 42 ? -5.192  66.447  -16.468 1.00 59.42 ? 591 ARG C NH1 1 
ATOM   1282 N NH2 . ARG C 2 42 ? -4.437  68.571  -16.935 1.00 65.22 ? 591 ARG C NH2 1 
ATOM   1283 N N   . LYS C 2 43 ? -7.738  66.880  -13.988 1.00 43.84 ? 592 LYS C N   1 
ATOM   1284 C CA  . LYS C 2 43 ? -6.663  66.070  -13.447 1.00 42.66 ? 592 LYS C CA  1 
ATOM   1285 C C   . LYS C 2 43 ? -7.222  64.984  -12.543 1.00 43.55 ? 592 LYS C C   1 
ATOM   1286 O O   . LYS C 2 43 ? -6.652  63.887  -12.452 1.00 44.63 ? 592 LYS C O   1 
ATOM   1287 C CB  . LYS C 2 43 ? -5.671  66.978  -12.714 1.00 43.05 ? 592 LYS C CB  1 
ATOM   1288 C CG  . LYS C 2 43 ? -4.224  66.617  -12.953 1.00 48.70 ? 592 LYS C CG  1 
ATOM   1289 C CD  . LYS C 2 43 ? -3.277  67.785  -12.696 1.00 54.69 ? 592 LYS C CD  1 
ATOM   1290 C CE  . LYS C 2 43 ? -3.251  68.755  -13.878 1.00 61.16 ? 592 LYS C CE  1 
ATOM   1291 N NZ  . LYS C 2 43 ? -2.716  70.126  -13.569 1.00 61.34 ? 592 LYS C NZ  1 
ATOM   1292 N N   . LYS C 2 44 ? -8.354  65.261  -11.891 1.00 43.93 ? 593 LYS C N   1 
ATOM   1293 C CA  . LYS C 2 44 ? -9.009  64.273  -11.043 1.00 41.59 ? 593 LYS C CA  1 
ATOM   1294 C C   . LYS C 2 44 ? -9.707  63.203  -11.889 1.00 46.47 ? 593 LYS C C   1 
ATOM   1295 O O   . LYS C 2 44 ? -9.635  62.006  -11.573 1.00 44.91 ? 593 LYS C O   1 
ATOM   1296 C CB  . LYS C 2 44 ? -9.984  64.982  -10.096 1.00 33.30 ? 593 LYS C CB  1 
ATOM   1297 C CG  . LYS C 2 44 ? -10.468 64.143  -8.931  1.00 46.95 ? 593 LYS C CG  1 
ATOM   1298 C CD  . LYS C 2 44 ? -9.613  64.324  -7.682  1.00 53.27 ? 593 LYS C CD  1 
ATOM   1299 C CE  . LYS C 2 44 ? -9.685  63.057  -6.808  1.00 60.96 ? 593 LYS C CE  1 
ATOM   1300 N NZ  . LYS C 2 44 ? -8.962  63.146  -5.495  1.00 59.01 ? 593 LYS C NZ  1 
ATOM   1301 N N   . GLU C 2 45 ? -10.363 63.613  -12.981 1.00 43.36 ? 594 GLU C N   1 
ATOM   1302 C CA  . GLU C 2 45 ? -10.944 62.647  -13.895 1.00 35.66 ? 594 GLU C CA  1 
ATOM   1303 C C   . GLU C 2 45 ? -9.893  61.753  -14.512 1.00 41.11 ? 594 GLU C C   1 
ATOM   1304 O O   . GLU C 2 45 ? -10.219 60.630  -14.906 1.00 49.22 ? 594 GLU C O   1 
ATOM   1305 C CB  . GLU C 2 45 ? -11.708 63.348  -15.001 1.00 40.56 ? 594 GLU C CB  1 
ATOM   1306 N N   . GLU C 2 46 ? -8.639  62.206  -14.604 1.00 39.79 ? 595 GLU C N   1 
ATOM   1307 C CA  . GLU C 2 46 ? -7.600  61.291  -15.067 1.00 41.06 ? 595 GLU C CA  1 
ATOM   1308 C C   . GLU C 2 46 ? -7.172  60.332  -13.964 1.00 46.88 ? 595 GLU C C   1 
ATOM   1309 O O   . GLU C 2 46 ? -6.747  59.208  -14.259 1.00 46.93 ? 595 GLU C O   1 
ATOM   1310 C CB  . GLU C 2 46 ? -6.367  62.031  -15.578 1.00 37.36 ? 595 GLU C CB  1 
ATOM   1311 C CG  . GLU C 2 46 ? -6.531  62.694  -16.920 1.00 48.16 ? 595 GLU C CG  1 
ATOM   1312 C CD  . GLU C 2 46 ? -6.451  61.756  -18.108 1.00 62.25 ? 595 GLU C CD  1 
ATOM   1313 O OE1 . GLU C 2 46 ? -6.533  60.519  -17.935 1.00 58.92 ? 595 GLU C OE1 1 
ATOM   1314 O OE2 . GLU C 2 46 ? -6.292  62.276  -19.238 1.00 70.46 ? 595 GLU C OE2 1 
ATOM   1315 N N   . GLU C 2 47 ? -7.259  60.747  -12.699 1.00 46.37 ? 596 GLU C N   1 
ATOM   1316 C CA  . GLU C 2 47 ? -6.944  59.817  -11.620 1.00 46.86 ? 596 GLU C CA  1 
ATOM   1317 C C   . GLU C 2 47 ? -7.879  58.624  -11.633 1.00 46.08 ? 596 GLU C C   1 
ATOM   1318 O O   . GLU C 2 47 ? -7.478  57.503  -11.287 1.00 44.25 ? 596 GLU C O   1 
ATOM   1319 C CB  . GLU C 2 47 ? -7.054  60.498  -10.273 1.00 42.77 ? 596 GLU C CB  1 
ATOM   1320 C CG  . GLU C 2 47 ? -5.882  61.250  -9.852  1.00 49.43 ? 596 GLU C CG  1 
ATOM   1321 C CD  . GLU C 2 47 ? -6.177  61.886  -8.540  1.00 61.42 ? 596 GLU C CD  1 
ATOM   1322 O OE1 . GLU C 2 47 ? -6.670  61.141  -7.646  1.00 51.35 ? 596 GLU C OE1 1 
ATOM   1323 O OE2 . GLU C 2 47 ? -5.977  63.125  -8.430  1.00 67.37 ? 596 GLU C OE2 1 
ATOM   1324 N N   . MET C 2 48 ? -9.148  58.859  -11.967 1.00 44.82 ? 597 MET C N   1 
ATOM   1325 C CA  . MET C 2 48 ? -10.125 57.783  -11.987 1.00 44.92 ? 597 MET C CA  1 
ATOM   1326 C C   . MET C 2 48 ? -9.842  56.822  -13.122 1.00 46.62 ? 597 MET C C   1 
ATOM   1327 O O   . MET C 2 48 ? -9.865  55.597  -12.936 1.00 41.84 ? 597 MET C O   1 
ATOM   1328 C CB  . MET C 2 48 ? -11.518 58.356  -12.130 1.00 42.96 ? 597 MET C CB  1 
ATOM   1329 C CG  . MET C 2 48 ? -12.613 57.385  -11.844 1.00 49.26 ? 597 MET C CG  1 
ATOM   1330 S SD  . MET C 2 48 ? -14.061 58.410  -11.722 1.00 59.43 ? 597 MET C SD  1 
ATOM   1331 C CE  . MET C 2 48 ? -15.409 57.289  -12.063 1.00 65.89 ? 597 MET C CE  1 
ATOM   1332 N N   . LYS C 2 49 ? -9.582  57.371  -14.305 1.00 42.87 ? 598 LYS C N   1 
ATOM   1333 C CA  . LYS C 2 49 ? -9.237  56.524  -15.431 1.00 46.90 ? 598 LYS C CA  1 
ATOM   1334 C C   . LYS C 2 49 ? -8.124  55.564  -15.034 1.00 43.88 ? 598 LYS C C   1 
ATOM   1335 O O   . LYS C 2 49 ? -8.341  54.355  -14.937 1.00 47.52 ? 598 LYS C O   1 
ATOM   1336 C CB  . LYS C 2 49 ? -8.850  57.392  -16.623 1.00 46.47 ? 598 LYS C CB  1 
ATOM   1337 C CG  . LYS C 2 49 ? -10.037 58.170  -17.183 1.00 51.73 ? 598 LYS C CG  1 
ATOM   1338 N N   . GLN C 2 50 ? -6.961  56.112  -14.689 1.00 39.66 ? 599 GLN C N   1 
ATOM   1339 C CA  . GLN C 2 50 ? -5.800  55.286  -14.367 1.00 38.59 ? 599 GLN C CA  1 
ATOM   1340 C C   . GLN C 2 50 ? -6.094  54.272  -13.265 1.00 38.45 ? 599 GLN C C   1 
ATOM   1341 O O   . GLN C 2 50 ? -5.595  53.146  -13.299 1.00 41.54 ? 599 GLN C O   1 
ATOM   1342 C CB  . GLN C 2 50 ? -4.625  56.181  -13.960 1.00 44.20 ? 599 GLN C CB  1 
ATOM   1343 C CG  . GLN C 2 50 ? -4.747  56.772  -12.531 1.00 55.79 ? 599 GLN C CG  1 
ATOM   1344 C CD  . GLN C 2 50 ? -3.467  57.432  -12.007 1.00 63.57 ? 599 GLN C CD  1 
ATOM   1345 O OE1 . GLN C 2 50 ? -2.545  57.743  -12.771 1.00 69.03 ? 599 GLN C OE1 1 
ATOM   1346 N NE2 . GLN C 2 50 ? -3.383  57.581  -10.681 1.00 54.50 ? 599 GLN C NE2 1 
ATOM   1347 N N   . MET C 2 51 ? -6.884  54.652  -12.257 1.00 39.16 ? 600 MET C N   1 
ATOM   1348 C CA  . MET C 2 51 ? -7.132  53.741  -11.146 1.00 39.29 ? 600 MET C CA  1 
ATOM   1349 C C   . MET C 2 51 ? -8.161  52.696  -11.522 1.00 38.53 ? 600 MET C C   1 
ATOM   1350 O O   . MET C 2 51 ? -7.981  51.502  -11.258 1.00 37.10 ? 600 MET C O   1 
ATOM   1351 C CB  . MET C 2 51 ? -7.561  54.506  -9.882  1.00 43.62 ? 600 MET C CB  1 
ATOM   1352 C CG  . MET C 2 51 ? -8.300  53.680  -8.916  1.00 39.86 ? 600 MET C CG  1 
ATOM   1353 S SD  . MET C 2 51 ? -10.038 53.846  -8.997  1.00 39.18 ? 600 MET C SD  1 
ATOM   1354 C CE  . MET C 2 51 ? -10.425 52.421  -8.302  1.00 37.17 ? 600 MET C CE  1 
ATOM   1355 N N   . GLU C 2 52 ? -9.249  53.133  -12.139 1.00 42.20 ? 601 GLU C N   1 
ATOM   1356 C CA  . GLU C 2 52 ? -10.241 52.190  -12.616 1.00 38.18 ? 601 GLU C CA  1 
ATOM   1357 C C   . GLU C 2 52 ? -9.619  51.260  -13.635 1.00 38.77 ? 601 GLU C C   1 
ATOM   1358 O O   . GLU C 2 52 ? -9.870  50.050  -13.624 1.00 39.46 ? 601 GLU C O   1 
ATOM   1359 C CB  . GLU C 2 52 ? -11.402 52.958  -13.218 1.00 42.36 ? 601 GLU C CB  1 
ATOM   1360 C CG  . GLU C 2 52 ? -12.480 52.096  -13.735 1.00 43.20 ? 601 GLU C CG  1 
ATOM   1361 C CD  . GLU C 2 52 ? -13.586 52.914  -14.303 1.00 42.75 ? 601 GLU C CD  1 
ATOM   1362 O OE1 . GLU C 2 52 ? -14.747 52.633  -13.924 1.00 40.50 ? 601 GLU C OE1 1 
ATOM   1363 O OE2 . GLU C 2 52 ? -13.271 53.820  -15.127 1.00 36.89 ? 601 GLU C OE2 1 
ATOM   1364 N N   . GLU C 2 53 ? -8.771  51.802  -14.505 1.00 37.58 ? 602 GLU C N   1 
ATOM   1365 C CA  . GLU C 2 53 ? -8.089  50.953  -15.463 1.00 39.58 ? 602 GLU C CA  1 
ATOM   1366 C C   . GLU C 2 53 ? -7.042  50.070  -14.802 1.00 40.92 ? 602 GLU C C   1 
ATOM   1367 O O   . GLU C 2 53 ? -6.701  49.022  -15.354 1.00 44.08 ? 602 GLU C O   1 
ATOM   1368 C CB  . GLU C 2 53 ? -7.465  51.797  -16.571 1.00 43.61 ? 602 GLU C CB  1 
ATOM   1369 C CG  . GLU C 2 53 ? -8.497  52.233  -17.631 1.00 57.51 ? 602 GLU C CG  1 
ATOM   1370 C CD  . GLU C 2 53 ? -7.948  53.210  -18.677 1.00 61.57 ? 602 GLU C CD  1 
ATOM   1371 O OE1 . GLU C 2 53 ? -7.320  54.224  -18.286 1.00 60.95 ? 602 GLU C OE1 1 
ATOM   1372 O OE2 . GLU C 2 53 ? -8.145  52.958  -19.893 1.00 54.20 ? 602 GLU C OE2 1 
ATOM   1373 N N   . ARG C 2 54 ? -6.553  50.440  -13.620 1.00 39.15 ? 603 ARG C N   1 
ATOM   1374 C CA  . ARG C 2 54 ? -5.610  49.571  -12.924 1.00 36.15 ? 603 ARG C CA  1 
ATOM   1375 C C   . ARG C 2 54 ? -6.324  48.377  -12.300 1.00 36.70 ? 603 ARG C C   1 
ATOM   1376 O O   . ARG C 2 54 ? -5.828  47.243  -12.361 1.00 36.19 ? 603 ARG C O   1 
ATOM   1377 C CB  . ARG C 2 54 ? -4.868  50.364  -11.855 1.00 37.99 ? 603 ARG C CB  1 
ATOM   1378 C CG  . ARG C 2 54 ? -3.871  49.552  -11.067 1.00 45.23 ? 603 ARG C CG  1 
ATOM   1379 C CD  . ARG C 2 54 ? -3.678  50.186  -9.701  1.00 49.96 ? 603 ARG C CD  1 
ATOM   1380 N NE  . ARG C 2 54 ? -3.482  49.174  -8.672  1.00 50.97 ? 603 ARG C NE  1 
ATOM   1381 C CZ  . ARG C 2 54 ? -3.162  49.443  -7.414  1.00 51.81 ? 603 ARG C CZ  1 
ATOM   1382 N NH1 . ARG C 2 54 ? -3.044  50.698  -7.013  1.00 54.16 ? 603 ARG C NH1 1 
ATOM   1383 N NH2 . ARG C 2 54 ? -2.992  48.454  -6.548  1.00 60.92 ? 603 ARG C NH2 1 
ATOM   1384 N N   . TYR C 2 55 ? -7.488  48.601  -11.697 1.00 35.49 ? 604 TYR C N   1 
ATOM   1385 C CA  . TYR C 2 55 ? -8.228  47.484  -11.126 1.00 33.72 ? 604 TYR C CA  1 
ATOM   1386 C C   . TYR C 2 55 ? -8.943  46.633  -12.175 1.00 31.95 ? 604 TYR C C   1 
ATOM   1387 O O   . TYR C 2 55 ? -9.130  45.438  -11.952 1.00 29.36 ? 604 TYR C O   1 
ATOM   1388 C CB  . TYR C 2 55 ? -9.235  47.974  -10.093 1.00 33.84 ? 604 TYR C CB  1 
ATOM   1389 C CG  . TYR C 2 55 ? -8.662  48.456  -8.772  1.00 38.41 ? 604 TYR C CG  1 
ATOM   1390 C CD1 . TYR C 2 55 ? -8.786  47.680  -7.617  1.00 44.98 ? 604 TYR C CD1 1 
ATOM   1391 C CD2 . TYR C 2 55 ? -8.045  49.689  -8.655  1.00 42.68 ? 604 TYR C CD2 1 
ATOM   1392 C CE1 . TYR C 2 55 ? -8.299  48.122  -6.386  1.00 40.50 ? 604 TYR C CE1 1 
ATOM   1393 C CE2 . TYR C 2 55 ? -7.552  50.131  -7.430  1.00 43.64 ? 604 TYR C CE2 1 
ATOM   1394 C CZ  . TYR C 2 55 ? -7.685  49.344  -6.308  1.00 37.72 ? 604 TYR C CZ  1 
ATOM   1395 O OH  . TYR C 2 55 ? -7.194  49.776  -5.105  1.00 43.13 ? 604 TYR C OH  1 
ATOM   1396 N N   . LYS C 2 56 ? -9.360  47.196  -13.310 1.00 32.47 ? 605 LYS C N   1 
ATOM   1397 C CA  . LYS C 2 56 ? -9.943  46.341  -14.346 1.00 33.55 ? 605 LYS C CA  1 
ATOM   1398 C C   . LYS C 2 56 ? -8.936  45.296  -14.829 1.00 32.76 ? 605 LYS C C   1 
ATOM   1399 O O   . LYS C 2 56 ? -9.300  44.153  -15.139 1.00 23.01 ? 605 LYS C O   1 
ATOM   1400 C CB  . LYS C 2 56 ? -10.423 47.188  -15.530 1.00 37.59 ? 605 LYS C CB  1 
ATOM   1401 C CG  . LYS C 2 56 ? -11.793 47.861  -15.396 1.00 40.42 ? 605 LYS C CG  1 
ATOM   1402 C CD  . LYS C 2 56 ? -11.796 49.165  -16.219 1.00 44.60 ? 605 LYS C CD  1 
ATOM   1403 C CE  . LYS C 2 56 ? -13.195 49.765  -16.425 1.00 48.20 ? 605 LYS C CE  1 
ATOM   1404 N NZ  . LYS C 2 56 ? -13.170 50.922  -17.404 1.00 47.71 ? 605 LYS C NZ  1 
ATOM   1405 N N   . LYS C 2 57 ? -7.666  45.687  -14.893 1.00 35.36 ? 606 LYS C N   1 
ATOM   1406 C CA  . LYS C 2 57 ? -6.593  44.816  -15.353 1.00 34.61 ? 606 LYS C CA  1 
ATOM   1407 C C   . LYS C 2 57 ? -6.461  43.579  -14.481 1.00 32.77 ? 606 LYS C C   1 
ATOM   1408 O O   . LYS C 2 57 ? -6.518  42.454  -14.974 1.00 35.49 ? 606 LYS C O   1 
ATOM   1409 C CB  . LYS C 2 57 ? -5.276  45.597  -15.365 1.00 43.20 ? 606 LYS C CB  1 
ATOM   1410 C CG  . LYS C 2 57 ? -4.369  45.354  -16.587 1.00 51.65 ? 606 LYS C CG  1 
ATOM   1411 C CD  . LYS C 2 57 ? -2.952  45.926  -16.385 1.00 53.27 ? 606 LYS C CD  1 
ATOM   1412 C CE  . LYS C 2 57 ? -2.036  45.575  -17.559 1.00 57.01 ? 606 LYS C CE  1 
ATOM   1413 N NZ  . LYS C 2 57 ? -1.319  46.763  -18.102 1.00 58.14 ? 606 LYS C NZ  1 
ATOM   1414 N N   . TYR C 2 58 ? -6.254  43.764  -13.179 1.00 34.52 ? 607 TYR C N   1 
ATOM   1415 C CA  . TYR C 2 58 ? -6.049  42.594  -12.325 1.00 31.20 ? 607 TYR C CA  1 
ATOM   1416 C C   . TYR C 2 58 ? -7.331  41.835  -12.026 1.00 31.69 ? 607 TYR C C   1 
ATOM   1417 O O   . TYR C 2 58 ? -7.244  40.677  -11.609 1.00 36.26 ? 607 TYR C O   1 
ATOM   1418 C CB  . TYR C 2 58 ? -5.362  42.953  -10.990 1.00 33.12 ? 607 TYR C CB  1 
ATOM   1419 C CG  . TYR C 2 58 ? -3.849  43.144  -11.089 1.00 37.83 ? 607 TYR C CG  1 
ATOM   1420 C CD1 . TYR C 2 58 ? -3.147  42.764  -12.241 1.00 35.30 ? 607 TYR C CD1 1 
ATOM   1421 C CD2 . TYR C 2 58 ? -3.109  43.625  -10.006 1.00 43.10 ? 607 TYR C CD2 1 
ATOM   1422 C CE1 . TYR C 2 58 ? -1.765  42.926  -12.340 1.00 37.81 ? 607 TYR C CE1 1 
ATOM   1423 C CE2 . TYR C 2 58 ? -1.710  43.782  -10.089 1.00 39.56 ? 607 TYR C CE2 1 
ATOM   1424 C CZ  . TYR C 2 58 ? -1.048  43.428  -11.254 1.00 39.99 ? 607 TYR C CZ  1 
ATOM   1425 O OH  . TYR C 2 58 ? 0.325   43.576  -11.343 1.00 36.91 ? 607 TYR C OH  1 
ATOM   1426 N N   . LEU C 2 59 ? -8.507  42.410  -12.235 1.00 32.35 ? 608 LEU C N   1 
ATOM   1427 C CA  . LEU C 2 59 ? -9.705  41.602  -12.050 1.00 28.66 ? 608 LEU C CA  1 
ATOM   1428 C C   . LEU C 2 59 ? -10.101 40.826  -13.295 1.00 32.26 ? 608 LEU C C   1 
ATOM   1429 O O   . LEU C 2 59 ? -11.026 40.012  -13.221 1.00 35.25 ? 608 LEU C O   1 
ATOM   1430 C CB  . LEU C 2 59 ? -10.879 42.458  -11.571 1.00 32.77 ? 608 LEU C CB  1 
ATOM   1431 C CG  . LEU C 2 59 ? -10.851 42.790  -10.071 1.00 37.00 ? 608 LEU C CG  1 
ATOM   1432 C CD1 . LEU C 2 59 ? -11.261 44.239  -9.802  1.00 34.71 ? 608 LEU C CD1 1 
ATOM   1433 C CD2 . LEU C 2 59 ? -11.710 41.820  -9.220  1.00 34.30 ? 608 LEU C CD2 1 
ATOM   1434 N N   . GLU C 2 60 ? -9.450  41.055  -14.439 1.00 33.67 ? 609 GLU C N   1 
ATOM   1435 C CA  . GLU C 2 60 ? -9.533  40.052  -15.494 1.00 27.52 ? 609 GLU C CA  1 
ATOM   1436 C C   . GLU C 2 60 ? -8.597  38.910  -15.180 1.00 25.78 ? 609 GLU C C   1 
ATOM   1437 O O   . GLU C 2 60 ? -9.000  37.744  -15.214 1.00 28.90 ? 609 GLU C O   1 
ATOM   1438 C CB  . GLU C 2 60 ? -9.201  40.630  -16.866 1.00 27.90 ? 609 GLU C CB  1 
ATOM   1439 C CG  . GLU C 2 60 ? -10.273 41.538  -17.392 1.00 34.90 ? 609 GLU C CG  1 
ATOM   1440 C CD  . GLU C 2 60 ? -11.675 41.100  -16.975 1.00 39.70 ? 609 GLU C CD  1 
ATOM   1441 O OE1 . GLU C 2 60 ? -12.317 41.856  -16.208 1.00 38.17 ? 609 GLU C OE1 1 
ATOM   1442 O OE2 . GLU C 2 60 ? -12.122 39.998  -17.376 1.00 45.50 ? 609 GLU C OE2 1 
ATOM   1443 N N   . LYS C 2 61 ? -7.349  39.230  -14.853 1.00 23.79 ? 610 LYS C N   1 
ATOM   1444 C CA  . LYS C 2 61 ? -6.399  38.197  -14.458 1.00 26.76 ? 610 LYS C CA  1 
ATOM   1445 C C   . LYS C 2 61 ? -6.975  37.317  -13.346 1.00 25.45 ? 610 LYS C C   1 
ATOM   1446 O O   . LYS C 2 61 ? -6.881  36.083  -13.399 1.00 20.27 ? 610 LYS C O   1 
ATOM   1447 C CB  . LYS C 2 61 ? -5.089  38.857  -14.037 1.00 25.11 ? 610 LYS C CB  1 
ATOM   1448 C CG  . LYS C 2 61 ? -4.497  39.719  -15.131 1.00 32.82 ? 610 LYS C CG  1 
ATOM   1449 C CD  . LYS C 2 61 ? -3.148  40.298  -14.756 1.00 32.34 ? 610 LYS C CD  1 
ATOM   1450 C CE  . LYS C 2 61 ? -2.696  41.326  -15.777 1.00 42.81 ? 610 LYS C CE  1 
ATOM   1451 N NZ  . LYS C 2 61 ? -1.372  41.916  -15.426 1.00 50.07 ? 610 LYS C NZ  1 
ATOM   1452 N N   . ALA C 2 62 ? -7.600  37.935  -12.348 1.00 27.57 ? 611 ALA C N   1 
ATOM   1453 C CA  . ALA C 2 62 ? -8.302  37.172  -11.329 1.00 23.15 ? 611 ALA C CA  1 
ATOM   1454 C C   . ALA C 2 62 ? -9.376  36.301  -11.963 1.00 22.47 ? 611 ALA C C   1 
ATOM   1455 O O   . ALA C 2 62 ? -9.421  35.093  -11.720 1.00 27.59 ? 611 ALA C O   1 
ATOM   1456 C CB  . ALA C 2 62 ? -8.903  38.112  -10.287 1.00 22.13 ? 611 ALA C CB  1 
ATOM   1457 N N   . LYS C 2 63 ? -10.246 36.896  -12.786 1.00 18.02 ? 612 LYS C N   1 
ATOM   1458 C CA  . LYS C 2 63 ? -11.291 36.112  -13.439 1.00 21.34 ? 612 LYS C CA  1 
ATOM   1459 C C   . LYS C 2 63 ? -10.691 35.034  -14.327 1.00 25.75 ? 612 LYS C C   1 
ATOM   1460 O O   . LYS C 2 63 ? -11.226 33.919  -14.436 1.00 21.50 ? 612 LYS C O   1 
ATOM   1461 C CB  . LYS C 2 63 ? -12.191 37.008  -14.273 1.00 28.14 ? 612 LYS C CB  1 
ATOM   1462 C CG  . LYS C 2 63 ? -13.569 37.223  -13.721 1.00 28.49 ? 612 LYS C CG  1 
ATOM   1463 C CD  . LYS C 2 63 ? -14.451 37.808  -14.806 1.00 33.05 ? 612 LYS C CD  1 
ATOM   1464 C CE  . LYS C 2 63 ? -15.870 37.985  -14.327 1.00 36.63 ? 612 LYS C CE  1 
ATOM   1465 N NZ  . LYS C 2 63 ? -16.863 37.862  -15.437 1.00 35.78 ? 612 LYS C NZ  1 
ATOM   1466 N N   . SER C 2 64 ? -9.580  35.358  -14.977 1.00 25.41 ? 613 SER C N   1 
ATOM   1467 C CA  . SER C 2 64 ? -8.879  34.351  -15.748 1.00 23.65 ? 613 SER C CA  1 
ATOM   1468 C C   . SER C 2 64 ? -8.412  33.225  -14.836 1.00 22.82 ? 613 SER C C   1 
ATOM   1469 O O   . SER C 2 64 ? -8.627  32.052  -15.143 1.00 28.11 ? 613 SER C O   1 
ATOM   1470 C CB  . SER C 2 64 ? -7.708  34.987  -16.475 1.00 25.77 ? 613 SER C CB  1 
ATOM   1471 O OG  . SER C 2 64 ? -7.473  34.326  -17.694 1.00 29.17 ? 613 SER C OG  1 
ATOM   1472 N N   . VAL C 2 65 ? -7.789  33.565  -13.710 1.00 21.01 ? 614 VAL C N   1 
ATOM   1473 C CA  . VAL C 2 65 ? -7.316  32.516  -12.808 1.00 18.88 ? 614 VAL C CA  1 
ATOM   1474 C C   . VAL C 2 65 ? -8.497  31.737  -12.256 1.00 20.99 ? 614 VAL C C   1 
ATOM   1475 O O   . VAL C 2 65 ? -8.428  30.524  -12.046 1.00 19.16 ? 614 VAL C O   1 
ATOM   1476 C CB  . VAL C 2 65 ? -6.434  33.103  -11.690 1.00 22.62 ? 614 VAL C CB  1 
ATOM   1477 C CG1 . VAL C 2 65 ? -6.177  32.071  -10.609 1.00 23.23 ? 614 VAL C CG1 1 
ATOM   1478 C CG2 . VAL C 2 65 ? -5.087  33.517  -12.249 1.00 20.76 ? 614 VAL C CG2 1 
ATOM   1479 N N   . ILE C 2 66 ? -9.613  32.410  -12.048 1.00 21.26 ? 615 ILE C N   1 
ATOM   1480 C CA  . ILE C 2 66 ? -10.764 31.667  -11.564 1.00 22.95 ? 615 ILE C CA  1 
ATOM   1481 C C   . ILE C 2 66 ? -11.265 30.702  -12.631 1.00 22.23 ? 615 ILE C C   1 
ATOM   1482 O O   . ILE C 2 66 ? -11.618 29.559  -12.337 1.00 18.80 ? 615 ILE C O   1 
ATOM   1483 C CB  . ILE C 2 66 ? -11.849 32.639  -11.064 1.00 22.44 ? 615 ILE C CB  1 
ATOM   1484 C CG1 . ILE C 2 66 ? -11.602 32.941  -9.588  1.00 22.95 ? 615 ILE C CG1 1 
ATOM   1485 C CG2 . ILE C 2 66 ? -13.238 32.073  -11.274 1.00 26.68 ? 615 ILE C CG2 1 
ATOM   1486 C CD1 . ILE C 2 66 ? -12.242 34.192  -9.102  1.00 24.20 ? 615 ILE C CD1 1 
ATOM   1487 N N   . ARG C 2 67 ? -11.276 31.139  -13.904 1.00 28.80 ? 616 ARG C N   1 
ATOM   1488 C CA  . ARG C 2 67 ? -11.715 30.276  -15.001 1.00 25.83 ? 616 ARG C CA  1 
ATOM   1489 C C   . ARG C 2 67 ? -10.774 29.106  -15.225 1.00 25.70 ? 616 ARG C C   1 
ATOM   1490 O O   . ARG C 2 67 ? -11.216 28.069  -15.720 1.00 31.06 ? 616 ARG C O   1 
ATOM   1491 C CB  . ARG C 2 67 ? -11.829 31.059  -16.324 1.00 29.60 ? 616 ARG C CB  1 
ATOM   1492 C CG  . ARG C 2 67 ? -13.148 31.805  -16.563 1.00 33.33 ? 616 ARG C CG  1 
ATOM   1493 C CD  . ARG C 2 67 ? -13.171 32.615  -17.898 1.00 36.36 ? 616 ARG C CD  1 
ATOM   1494 N NE  . ARG C 2 67 ? -13.081 34.086  -17.823 1.00 34.48 ? 616 ARG C NE  1 
ATOM   1495 C CZ  . ARG C 2 67 ? -12.012 34.797  -18.206 1.00 37.35 ? 616 ARG C CZ  1 
ATOM   1496 N NH1 . ARG C 2 67 ? -10.938 34.173  -18.682 1.00 30.02 ? 616 ARG C NH1 1 
ATOM   1497 N NH2 . ARG C 2 67 ? -12.004 36.135  -18.122 1.00 34.47 ? 616 ARG C NH2 1 
ATOM   1498 N N   . THR C 2 68 ? -9.492  29.242  -14.899 1.00 22.92 ? 617 THR C N   1 
ATOM   1499 C CA  . THR C 2 68 ? -8.633  28.078  -15.048 1.00 26.17 ? 617 THR C CA  1 
ATOM   1500 C C   . THR C 2 68 ? -8.904  27.012  -13.976 1.00 25.26 ? 617 THR C C   1 
ATOM   1501 O O   . THR C 2 68 ? -9.043  25.838  -14.327 1.00 28.22 ? 617 THR C O   1 
ATOM   1502 C CB  . THR C 2 68 ? -7.147  28.489  -15.116 1.00 24.91 ? 617 THR C CB  1 
ATOM   1503 O OG1 . THR C 2 68 ? -6.297  27.332  -15.004 1.00 28.05 ? 617 THR C OG1 1 
ATOM   1504 C CG2 . THR C 2 68 ? -6.742  29.501  -14.139 1.00 25.90 ? 617 THR C CG2 1 
ATOM   1505 N N   . LEU C 2 69 ? -9.097  27.367  -12.707 1.00 23.24 ? 618 LEU C N   1 
ATOM   1506 C CA  . LEU C 2 69 ? -9.480  26.377  -11.693 1.00 20.37 ? 618 LEU C CA  1 
ATOM   1507 C C   . LEU C 2 69 ? -10.967 26.076  -11.671 1.00 21.14 ? 618 LEU C C   1 
ATOM   1508 O O   . LEU C 2 69 ? -11.538 25.900  -10.599 1.00 22.20 ? 618 LEU C O   1 
ATOM   1509 C CB  . LEU C 2 69 ? -9.011  26.811  -10.309 1.00 22.68 ? 618 LEU C CB  1 
ATOM   1510 C CG  . LEU C 2 69 ? -7.624  27.469  -10.184 1.00 24.59 ? 618 LEU C CG  1 
ATOM   1511 C CD1 . LEU C 2 69 ? -7.524  28.381  -8.947  1.00 21.69 ? 618 LEU C CD1 1 
ATOM   1512 C CD2 . LEU C 2 69 ? -6.580  26.394  -10.173 1.00 27.32 ? 618 LEU C CD2 1 
ATOM   1513 N N   . ASP C 2 70 ? -11.627 26.034  -12.815 1.00 21.97 ? 619 ASP C N   1 
ATOM   1514 C CA  . ASP C 2 70 ? -12.987 25.529  -12.904 1.00 28.84 ? 619 ASP C CA  1 
ATOM   1515 C C   . ASP C 2 70 ? -13.122 24.265  -12.084 1.00 36.49 ? 619 ASP C C   1 
ATOM   1516 O O   . ASP C 2 70 ? -12.375 23.282  -12.292 1.00 35.88 ? 619 ASP C O   1 
ATOM   1517 C CB  . ASP C 2 70 ? -13.322 25.277  -14.373 1.00 30.68 ? 619 ASP C CB  1 
ATOM   1518 C CG  . ASP C 2 70 ? -14.675 24.666  -14.546 1.00 33.13 ? 619 ASP C CG  1 
ATOM   1519 O OD1 . ASP C 2 70 ? -15.556 24.970  -13.734 1.00 32.61 ? 619 ASP C OD1 1 
ATOM   1520 O OD2 . ASP C 2 70 ? -14.845 23.880  -15.502 1.00 39.13 ? 619 ASP C OD2 1 
ATOM   1521 N N   . PRO C 2 71 ? -14.029 24.213  -11.075 1.00 37.22 ? 620 PRO C N   1 
ATOM   1522 C CA  . PRO C 2 71 ? -14.156 23.046  -10.216 1.00 36.20 ? 620 PRO C CA  1 
ATOM   1523 C C   . PRO C 2 71 ? -14.907 21.866  -10.812 1.00 38.60 ? 620 PRO C C   1 
ATOM   1524 O O   . PRO C 2 71 ? -15.061 20.862  -10.118 1.00 37.77 ? 620 PRO C O   1 
ATOM   1525 C CB  . PRO C 2 71 ? -14.916 23.595  -8.994  1.00 30.02 ? 620 PRO C CB  1 
ATOM   1526 C CG  . PRO C 2 71 ? -15.660 24.747  -9.505  1.00 27.35 ? 620 PRO C CG  1 
ATOM   1527 C CD  . PRO C 2 71 ? -14.760 25.374  -10.530 1.00 33.38 ? 620 PRO C CD  1 
ATOM   1528 N N   . LYS C 2 72 ? -15.406 21.950  -12.044 1.00 41.21 ? 621 LYS C N   1 
ATOM   1529 C CA  . LYS C 2 72 ? -16.091 20.819  -12.658 1.00 36.63 ? 621 LYS C CA  1 
ATOM   1530 C C   . LYS C 2 72 ? -15.130 19.868  -13.363 1.00 40.00 ? 621 LYS C C   1 
ATOM   1531 O O   . LYS C 2 72 ? -15.495 18.715  -13.600 1.00 49.64 ? 621 LYS C O   1 
ATOM   1532 C CB  . LYS C 2 72 ? -17.142 21.334  -13.643 1.00 41.38 ? 621 LYS C CB  1 
ATOM   1533 C CG  . LYS C 2 72 ? -18.031 22.438  -13.056 1.00 38.73 ? 621 LYS C CG  1 
ATOM   1534 C CD  . LYS C 2 72 ? -18.328 23.519  -14.078 1.00 30.10 ? 621 LYS C CD  1 
ATOM   1535 C CE  . LYS C 2 72 ? -18.551 24.848  -13.398 1.00 36.56 ? 621 LYS C CE  1 
ATOM   1536 N NZ  . LYS C 2 72 ? -19.664 24.809  -12.424 1.00 46.58 ? 621 LYS C NZ  1 
ATOM   1537 N N   . GLN C 2 73 ? -13.922 20.340  -13.699 1.00 43.13 ? 622 GLN C N   1 
ATOM   1538 C CA  . GLN C 2 73 ? -12.718 19.551  -14.063 1.00 53.74 ? 622 GLN C CA  1 
ATOM   1539 C C   . GLN C 2 73 ? -12.972 18.092  -14.505 1.00 73.91 ? 622 GLN C C   1 
ATOM   1540 O O   . GLN C 2 73 ? -12.140 17.443  -15.166 1.00 62.15 ? 622 GLN C O   1 
ATOM   1541 C CB  . GLN C 2 73 ? -11.739 19.557  -12.871 1.00 45.65 ? 622 GLN C CB  1 
ATOM   1542 C CG  . GLN C 2 73 ? -12.366 18.942  -11.604 1.00 54.70 ? 622 GLN C CG  1 
ATOM   1543 C CD  . GLN C 2 73 ? -11.468 18.965  -10.372 1.00 56.97 ? 622 GLN C CD  1 
ATOM   1544 O OE1 . GLN C 2 73 ? -10.830 19.977  -10.076 1.00 60.97 ? 622 GLN C OE1 1 
ATOM   1545 N NE2 . GLN C 2 73 ? -11.427 17.846  -9.640  1.00 48.47 ? 622 GLN C NE2 1 
ATOM   1546 N N   . MET D 2 3  ? -18.107 124.934 -14.341 1.00 46.48 ? 552 MET D N   1 
ATOM   1547 C CA  . MET D 2 3  ? -18.893 123.922 -15.065 1.00 47.81 ? 552 MET D CA  1 
ATOM   1548 C C   . MET D 2 3  ? -18.121 123.197 -16.142 1.00 48.37 ? 552 MET D C   1 
ATOM   1549 O O   . MET D 2 3  ? -18.484 122.092 -16.557 1.00 45.13 ? 552 MET D O   1 
ATOM   1550 C CB  . MET D 2 3  ? -20.106 124.519 -15.752 1.00 39.99 ? 552 MET D CB  1 
ATOM   1551 C CG  . MET D 2 3  ? -21.354 124.488 -14.960 1.00 46.09 ? 552 MET D CG  1 
ATOM   1552 S SD  . MET D 2 3  ? -22.668 124.283 -16.174 1.00 54.42 ? 552 MET D SD  1 
ATOM   1553 C CE  . MET D 2 3  ? -22.124 125.401 -17.477 1.00 42.96 ? 552 MET D CE  1 
ATOM   1554 N N   . GLU D 2 4  ? -17.119 123.880 -16.679 1.00 51.12 ? 553 GLU D N   1 
ATOM   1555 C CA  . GLU D 2 4  ? -16.130 123.189 -17.486 1.00 53.12 ? 553 GLU D CA  1 
ATOM   1556 C C   . GLU D 2 4  ? -15.687 121.925 -16.763 1.00 51.21 ? 553 GLU D C   1 
ATOM   1557 O O   . GLU D 2 4  ? -15.724 120.817 -17.312 1.00 52.82 ? 553 GLU D O   1 
ATOM   1558 C CB  . GLU D 2 4  ? -14.952 124.125 -17.722 1.00 53.04 ? 553 GLU D CB  1 
ATOM   1559 C CG  . GLU D 2 4  ? -13.638 123.424 -17.794 1.00 55.30 ? 553 GLU D CG  1 
ATOM   1560 C CD  . GLU D 2 4  ? -12.516 124.404 -17.642 1.00 64.95 ? 553 GLU D CD  1 
ATOM   1561 O OE1 . GLU D 2 4  ? -12.473 125.364 -18.445 1.00 67.76 ? 553 GLU D OE1 1 
ATOM   1562 O OE2 . GLU D 2 4  ? -11.711 124.238 -16.694 1.00 66.69 ? 553 GLU D OE2 1 
ATOM   1563 N N   . LYS D 2 5  ? -15.335 122.086 -15.489 1.00 52.73 ? 554 LYS D N   1 
ATOM   1564 C CA  . LYS D 2 5  ? -14.843 120.989 -14.669 1.00 50.52 ? 554 LYS D CA  1 
ATOM   1565 C C   . LYS D 2 5  ? -15.963 120.028 -14.278 1.00 43.10 ? 554 LYS D C   1 
ATOM   1566 O O   . LYS D 2 5  ? -15.700 118.853 -14.003 1.00 33.28 ? 554 LYS D O   1 
ATOM   1567 C CB  . LYS D 2 5  ? -14.152 121.603 -13.451 1.00 41.27 ? 554 LYS D CB  1 
ATOM   1568 C CG  . LYS D 2 5  ? -13.006 122.510 -13.878 1.00 49.67 ? 554 LYS D CG  1 
ATOM   1569 C CD  . LYS D 2 5  ? -12.839 123.715 -12.942 1.00 59.65 ? 554 LYS D CD  1 
ATOM   1570 C CE  . LYS D 2 5  ? -13.931 124.781 -13.164 1.00 53.43 ? 554 LYS D CE  1 
ATOM   1571 N NZ  . LYS D 2 5  ? -14.131 125.162 -14.600 1.00 55.87 ? 554 LYS D NZ  1 
ATOM   1572 N N   . LEU D 2 6  ? -17.212 120.510 -14.254 1.00 42.14 ? 555 LEU D N   1 
ATOM   1573 C CA  . LEU D 2 6  ? -18.367 119.719 -13.843 1.00 35.89 ? 555 LEU D CA  1 
ATOM   1574 C C   . LEU D 2 6  ? -18.859 118.819 -14.966 1.00 39.27 ? 555 LEU D C   1 
ATOM   1575 O O   . LEU D 2 6  ? -19.080 117.624 -14.762 1.00 41.29 ? 555 LEU D O   1 
ATOM   1576 C CB  . LEU D 2 6  ? -19.496 120.646 -13.379 1.00 40.71 ? 555 LEU D CB  1 
ATOM   1577 C CG  . LEU D 2 6  ? -20.831 119.994 -12.965 1.00 48.02 ? 555 LEU D CG  1 
ATOM   1578 C CD1 . LEU D 2 6  ? -20.627 118.883 -11.933 1.00 40.52 ? 555 LEU D CD1 1 
ATOM   1579 C CD2 . LEU D 2 6  ? -21.899 121.040 -12.506 1.00 33.06 ? 555 LEU D CD2 1 
ATOM   1580 N N   . HIS D 2 7  ? -19.081 119.393 -16.157 1.00 40.14 ? 556 HIS D N   1 
ATOM   1581 C CA  . HIS D 2 7  ? -19.317 118.570 -17.333 1.00 38.55 ? 556 HIS D CA  1 
ATOM   1582 C C   . HIS D 2 7  ? -18.260 117.492 -17.459 1.00 33.95 ? 556 HIS D C   1 
ATOM   1583 O O   . HIS D 2 7  ? -18.570 116.377 -17.878 1.00 33.39 ? 556 HIS D O   1 
ATOM   1584 C CB  . HIS D 2 7  ? -19.333 119.427 -18.612 1.00 47.95 ? 556 HIS D CB  1 
ATOM   1585 C CG  . HIS D 2 7  ? -20.630 120.128 -18.876 1.00 41.91 ? 556 HIS D CG  1 
ATOM   1586 N ND1 . HIS D 2 7  ? -21.764 119.915 -18.124 1.00 46.80 ? 556 HIS D ND1 1 
ATOM   1587 C CD2 . HIS D 2 7  ? -20.988 120.991 -19.857 1.00 39.67 ? 556 HIS D CD2 1 
ATOM   1588 C CE1 . HIS D 2 7  ? -22.758 120.644 -18.603 1.00 42.06 ? 556 HIS D CE1 1 
ATOM   1589 N NE2 . HIS D 2 7  ? -22.311 121.304 -19.656 1.00 45.69 ? 556 HIS D NE2 1 
ATOM   1590 N N   . GLU D 2 8  ? -17.011 117.812 -17.093 1.00 34.17 ? 557 GLU D N   1 
ATOM   1591 C CA  . GLU D 2 8  ? -15.870 116.901 -17.137 1.00 32.55 ? 557 GLU D CA  1 
ATOM   1592 C C   . GLU D 2 8  ? -15.990 115.753 -16.143 1.00 30.84 ? 557 GLU D C   1 
ATOM   1593 O O   . GLU D 2 8  ? -16.040 114.585 -16.532 1.00 33.15 ? 557 GLU D O   1 
ATOM   1594 C CB  . GLU D 2 8  ? -14.581 117.684 -16.875 1.00 37.35 ? 557 GLU D CB  1 
ATOM   1595 C CG  . GLU D 2 8  ? -13.343 117.142 -17.600 1.00 39.81 ? 557 GLU D CG  1 
ATOM   1596 C CD  . GLU D 2 8  ? -12.023 117.611 -16.981 1.00 48.09 ? 557 GLU D CD  1 
ATOM   1597 O OE1 . GLU D 2 8  ? -12.007 118.674 -16.311 1.00 48.90 ? 557 GLU D OE1 1 
ATOM   1598 O OE2 . GLU D 2 8  ? -11.008 116.894 -17.154 1.00 47.05 ? 557 GLU D OE2 1 
ATOM   1599 N N   . ALA D 2 9  ? -15.993 116.069 -14.856 1.00 35.52 ? 558 ALA D N   1 
ATOM   1600 C CA  . ALA D 2 9  ? -16.149 115.027 -13.857 1.00 26.93 ? 558 ALA D CA  1 
ATOM   1601 C C   . ALA D 2 9  ? -17.401 114.232 -14.117 1.00 28.28 ? 558 ALA D C   1 
ATOM   1602 O O   . ALA D 2 9  ? -17.415 113.010 -13.954 1.00 30.55 ? 558 ALA D O   1 
ATOM   1603 C CB  . ALA D 2 9  ? -16.202 115.641 -12.465 1.00 27.56 ? 558 ALA D CB  1 
ATOM   1604 N N   . ASN D 2 10 ? -18.478 114.894 -14.524 1.00 30.53 ? 559 ASN D N   1 
ATOM   1605 C CA  . ASN D 2 10 ? -19.696 114.150 -14.813 1.00 32.91 ? 559 ASN D CA  1 
ATOM   1606 C C   . ASN D 2 10 ? -19.547 113.245 -16.031 1.00 31.54 ? 559 ASN D C   1 
ATOM   1607 O O   . ASN D 2 10 ? -20.201 112.208 -16.111 1.00 30.53 ? 559 ASN D O   1 
ATOM   1608 C CB  . ASN D 2 10 ? -20.874 115.092 -15.004 1.00 33.42 ? 559 ASN D CB  1 
ATOM   1609 C CG  . ASN D 2 10 ? -21.838 115.029 -13.869 1.00 34.82 ? 559 ASN D CG  1 
ATOM   1610 O OD1 . ASN D 2 10 ? -21.463 114.687 -12.749 1.00 36.20 ? 559 ASN D OD1 1 
ATOM   1611 N ND2 . ASN D 2 10 ? -23.094 115.367 -14.138 1.00 42.33 ? 559 ASN D ND2 1 
ATOM   1612 N N   . ASN D 2 11 ? -18.705 113.629 -16.991 1.00 32.93 ? 560 ASN D N   1 
ATOM   1613 C CA  . ASN D 2 11 ? -18.441 112.756 -18.126 1.00 28.00 ? 560 ASN D CA  1 
ATOM   1614 C C   . ASN D 2 11 ? -17.641 111.554 -17.681 1.00 32.91 ? 560 ASN D C   1 
ATOM   1615 O O   . ASN D 2 11 ? -17.906 110.428 -18.119 1.00 38.90 ? 560 ASN D O   1 
ATOM   1616 C CB  . ASN D 2 11 ? -17.699 113.519 -19.214 1.00 30.97 ? 560 ASN D CB  1 
ATOM   1617 C CG  . ASN D 2 11 ? -18.645 114.261 -20.152 1.00 33.79 ? 560 ASN D CG  1 
ATOM   1618 O OD1 . ASN D 2 11 ? -19.645 113.705 -20.622 1.00 35.34 ? 560 ASN D OD1 1 
ATOM   1619 N ND2 . ASN D 2 11 ? -18.349 115.536 -20.401 1.00 31.88 ? 560 ASN D ND2 1 
ATOM   1620 N N   . GLU D 2 12 ? -16.669 111.768 -16.795 1.00 34.06 ? 561 GLU D N   1 
ATOM   1621 C CA  . GLU D 2 12 ? -15.968 110.650 -16.172 1.00 30.53 ? 561 GLU D CA  1 
ATOM   1622 C C   . GLU D 2 12 ? -16.876 109.833 -15.267 1.00 27.81 ? 561 GLU D C   1 
ATOM   1623 O O   . GLU D 2 12 ? -16.669 108.637 -15.117 1.00 34.39 ? 561 GLU D O   1 
ATOM   1624 C CB  . GLU D 2 12 ? -14.775 111.168 -15.376 1.00 33.06 ? 561 GLU D CB  1 
ATOM   1625 C CG  . GLU D 2 12 ? -13.795 110.113 -15.000 1.00 36.75 ? 561 GLU D CG  1 
ATOM   1626 C CD  . GLU D 2 12 ? -12.598 110.109 -15.919 1.00 47.00 ? 561 GLU D CD  1 
ATOM   1627 O OE1 . GLU D 2 12 ? -12.631 109.389 -16.959 1.00 41.68 ? 561 GLU D OE1 1 
ATOM   1628 O OE2 . GLU D 2 12 ? -11.636 110.848 -15.602 1.00 47.99 ? 561 GLU D OE2 1 
ATOM   1629 N N   . LEU D 2 13 ? -17.865 110.454 -14.630 1.00 31.04 ? 562 LEU D N   1 
ATOM   1630 C CA  . LEU D 2 13 ? -18.759 109.706 -13.751 1.00 32.86 ? 562 LEU D CA  1 
ATOM   1631 C C   . LEU D 2 13 ? -19.655 108.762 -14.538 1.00 35.36 ? 562 LEU D C   1 
ATOM   1632 O O   . LEU D 2 13 ? -19.944 107.651 -14.081 1.00 34.46 ? 562 LEU D O   1 
ATOM   1633 C CB  . LEU D 2 13 ? -19.625 110.658 -12.926 1.00 38.83 ? 562 LEU D CB  1 
ATOM   1634 C CG  . LEU D 2 13 ? -19.313 111.022 -11.475 1.00 38.00 ? 562 LEU D CG  1 
ATOM   1635 C CD1 . LEU D 2 13 ? -20.382 111.942 -10.892 1.00 32.33 ? 562 LEU D CD1 1 
ATOM   1636 C CD2 . LEU D 2 13 ? -19.249 109.729 -10.690 1.00 38.59 ? 562 LEU D CD2 1 
ATOM   1637 N N   . GLN D 2 14 ? -20.147 109.212 -15.696 1.00 38.41 ? 563 GLN D N   1 
ATOM   1638 C CA  . GLN D 2 14 ? -20.990 108.349 -16.520 1.00 38.96 ? 563 GLN D CA  1 
ATOM   1639 C C   . GLN D 2 14 ? -20.208 107.130 -16.974 1.00 33.31 ? 563 GLN D C   1 
ATOM   1640 O O   . GLN D 2 14 ? -20.752 106.021 -17.038 1.00 31.97 ? 563 GLN D O   1 
ATOM   1641 C CB  . GLN D 2 14 ? -21.534 109.130 -17.723 1.00 32.81 ? 563 GLN D CB  1 
ATOM   1642 C CG  . GLN D 2 14 ? -22.415 110.328 -17.328 1.00 39.04 ? 563 GLN D CG  1 
ATOM   1643 C CD  . GLN D 2 14 ? -23.005 111.088 -18.530 1.00 42.65 ? 563 GLN D CD  1 
ATOM   1644 O OE1 . GLN D 2 14 ? -23.006 110.584 -19.655 1.00 50.26 ? 563 GLN D OE1 1 
ATOM   1645 N NE2 . GLN D 2 14 ? -23.500 112.306 -18.288 1.00 36.12 ? 563 GLN D NE2 1 
ATOM   1646 N N   . LYS D 2 15 ? -18.919 107.327 -17.252 1.00 34.31 ? 564 LYS D N   1 
ATOM   1647 C CA  . LYS D 2 15 ? -18.070 106.278 -17.799 1.00 34.62 ? 564 LYS D CA  1 
ATOM   1648 C C   . LYS D 2 15 ? -17.695 105.249 -16.748 1.00 35.57 ? 564 LYS D C   1 
ATOM   1649 O O   . LYS D 2 15 ? -17.448 104.088 -17.087 1.00 39.95 ? 564 LYS D O   1 
ATOM   1650 C CB  . LYS D 2 15 ? -16.819 106.908 -18.428 1.00 35.29 ? 564 LYS D CB  1 
ATOM   1651 C CG  . LYS D 2 15 ? -15.588 106.013 -18.472 1.00 41.96 ? 564 LYS D CG  1 
ATOM   1652 C CD  . LYS D 2 15 ? -14.324 106.767 -18.901 1.00 43.11 ? 564 LYS D CD  1 
ATOM   1653 C CE  . LYS D 2 15 ? -13.059 105.933 -18.677 1.00 40.68 ? 564 LYS D CE  1 
ATOM   1654 N NZ  . LYS D 2 15 ? -11.956 106.312 -19.617 1.00 51.60 ? 564 LYS D NZ  1 
ATOM   1655 N N   . LYS D 2 16 ? -17.679 105.626 -15.473 1.00 36.43 ? 565 LYS D N   1 
ATOM   1656 C CA  . LYS D 2 16 ? -17.224 104.693 -14.448 1.00 37.61 ? 565 LYS D CA  1 
ATOM   1657 C C   . LYS D 2 16 ? -18.327 103.825 -13.855 1.00 30.17 ? 565 LYS D C   1 
ATOM   1658 O O   . LYS D 2 16 ? -18.018 102.772 -13.313 1.00 32.23 ? 565 LYS D O   1 
ATOM   1659 C CB  . LYS D 2 16 ? -16.505 105.447 -13.333 1.00 37.20 ? 565 LYS D CB  1 
ATOM   1660 C CG  . LYS D 2 16 ? -15.001 105.303 -13.442 1.00 37.27 ? 565 LYS D CG  1 
ATOM   1661 C CD  . LYS D 2 16 ? -14.273 106.600 -13.221 1.00 35.82 ? 565 LYS D CD  1 
ATOM   1662 C CE  . LYS D 2 16 ? -12.848 106.490 -13.745 1.00 48.43 ? 565 LYS D CE  1 
ATOM   1663 N NZ  . LYS D 2 16 ? -12.076 107.749 -13.476 1.00 53.79 ? 565 LYS D NZ  1 
ATOM   1664 N N   . ARG D 2 17 ? -19.594 104.217 -13.937 1.00 31.20 ? 566 ARG D N   1 
ATOM   1665 C CA  . ARG D 2 17 ? -20.651 103.311 -13.521 1.00 31.87 ? 566 ARG D CA  1 
ATOM   1666 C C   . ARG D 2 17 ? -21.163 102.446 -14.669 1.00 40.51 ? 566 ARG D C   1 
ATOM   1667 O O   . ARG D 2 17 ? -21.831 101.430 -14.421 1.00 41.04 ? 566 ARG D O   1 
ATOM   1668 C CB  . ARG D 2 17 ? -21.819 104.067 -12.901 1.00 33.24 ? 566 ARG D CB  1 
ATOM   1669 C CG  . ARG D 2 17 ? -22.379 105.221 -13.702 1.00 42.82 ? 566 ARG D CG  1 
ATOM   1670 C CD  . ARG D 2 17 ? -23.388 105.985 -12.824 1.00 49.57 ? 566 ARG D CD  1 
ATOM   1671 N NE  . ARG D 2 17 ? -23.678 107.337 -13.302 1.00 52.86 ? 566 ARG D NE  1 
ATOM   1672 C CZ  . ARG D 2 17 ? -23.463 108.450 -12.601 1.00 54.84 ? 566 ARG D CZ  1 
ATOM   1673 N NH1 . ARG D 2 17 ? -22.912 108.369 -11.394 1.00 53.06 ? 566 ARG D NH1 1 
ATOM   1674 N NH2 . ARG D 2 17 ? -23.770 109.649 -13.117 1.00 53.98 ? 566 ARG D NH2 1 
ATOM   1675 N N   . ALA D 2 18 ? -20.850 102.802 -15.914 1.00 39.03 ? 567 ALA D N   1 
ATOM   1676 C CA  . ALA D 2 18 ? -20.998 101.828 -16.988 1.00 43.91 ? 567 ALA D CA  1 
ATOM   1677 C C   . ALA D 2 18 ? -19.929 100.734 -16.926 1.00 45.01 ? 567 ALA D C   1 
ATOM   1678 O O   . ALA D 2 18 ? -20.053 99.728  -17.638 1.00 46.68 ? 567 ALA D O   1 
ATOM   1679 C CB  . ALA D 2 18 ? -20.968 102.528 -18.357 1.00 40.69 ? 567 ALA D CB  1 
ATOM   1680 N N   . ILE D 2 19 ? -18.898 100.901 -16.092 1.00 39.85 ? 568 ILE D N   1 
ATOM   1681 C CA  . ILE D 2 19 ? -17.842 99.896  -15.919 1.00 40.89 ? 568 ILE D CA  1 
ATOM   1682 C C   . ILE D 2 19 ? -18.186 98.925  -14.795 1.00 43.16 ? 568 ILE D C   1 
ATOM   1683 O O   . ILE D 2 19 ? -18.048 97.705  -14.934 1.00 41.33 ? 568 ILE D O   1 
ATOM   1684 C CB  . ILE D 2 19 ? -16.489 100.593 -15.642 1.00 39.53 ? 568 ILE D CB  1 
ATOM   1685 C CG1 . ILE D 2 19 ? -15.811 101.057 -16.924 1.00 35.75 ? 568 ILE D CG1 1 
ATOM   1686 C CG2 . ILE D 2 19 ? -15.539 99.664  -14.903 1.00 42.15 ? 568 ILE D CG2 1 
ATOM   1687 C CD1 . ILE D 2 19 ? -14.452 101.675 -16.660 1.00 38.81 ? 568 ILE D CD1 1 
ATOM   1688 N N   . ILE D 2 20 ? -18.581 99.483  -13.651 1.00 39.77 ? 569 ILE D N   1 
ATOM   1689 C CA  . ILE D 2 20 ? -19.124 98.695  -12.551 1.00 37.99 ? 569 ILE D CA  1 
ATOM   1690 C C   . ILE D 2 20 ? -20.276 97.831  -13.042 1.00 42.47 ? 569 ILE D C   1 
ATOM   1691 O O   . ILE D 2 20 ? -20.250 96.599  -12.925 1.00 47.60 ? 569 ILE D O   1 
ATOM   1692 C CB  . ILE D 2 20 ? -19.575 99.628  -11.422 1.00 36.69 ? 569 ILE D CB  1 
ATOM   1693 C CG1 . ILE D 2 20 ? -18.337 100.231 -10.750 1.00 33.59 ? 569 ILE D CG1 1 
ATOM   1694 C CG2 . ILE D 2 20 ? -20.516 98.891  -10.482 1.00 41.88 ? 569 ILE D CG2 1 
ATOM   1695 C CD1 . ILE D 2 20 ? -18.620 101.359 -9.776  1.00 30.23 ? 569 ILE D CD1 1 
ATOM   1696 N N   . GLU D 2 21 ? -21.298 98.468  -13.621 1.00 43.72 ? 570 GLU D N   1 
ATOM   1697 C CA  . GLU D 2 21 ? -22.429 97.713  -14.156 1.00 49.56 ? 570 GLU D CA  1 
ATOM   1698 C C   . GLU D 2 21 ? -22.013 96.629  -15.145 1.00 43.51 ? 570 GLU D C   1 
ATOM   1699 O O   . GLU D 2 21 ? -22.803 95.717  -15.402 1.00 43.39 ? 570 GLU D O   1 
ATOM   1700 C CB  . GLU D 2 21 ? -23.448 98.649  -14.832 1.00 50.06 ? 570 GLU D CB  1 
ATOM   1701 C CG  . GLU D 2 21 ? -24.295 99.499  -13.890 1.00 45.73 ? 570 GLU D CG  1 
ATOM   1702 C CD  . GLU D 2 21 ? -25.370 100.285 -14.635 1.00 53.48 ? 570 GLU D CD  1 
ATOM   1703 O OE1 . GLU D 2 21 ? -25.038 101.309 -15.270 1.00 56.86 ? 570 GLU D OE1 1 
ATOM   1704 O OE2 . GLU D 2 21 ? -26.550 99.862  -14.614 1.00 55.77 ? 570 GLU D OE2 1 
ATOM   1705 N N   . ASP D 2 22 ? -20.808 96.713  -15.718 1.00 43.30 ? 571 ASP D N   1 
ATOM   1706 C CA  . ASP D 2 22 ? -20.265 95.623  -16.523 1.00 48.61 ? 571 ASP D CA  1 
ATOM   1707 C C   . ASP D 2 22 ? -19.556 94.572  -15.672 1.00 50.19 ? 571 ASP D C   1 
ATOM   1708 O O   . ASP D 2 22 ? -19.615 93.384  -16.000 1.00 49.67 ? 571 ASP D O   1 
ATOM   1709 C CB  . ASP D 2 22 ? -19.281 96.152  -17.580 1.00 53.29 ? 571 ASP D CB  1 
ATOM   1710 C CG  . ASP D 2 22 ? -19.960 96.557  -18.889 1.00 58.95 ? 571 ASP D CG  1 
ATOM   1711 O OD1 . ASP D 2 22 ? -21.132 97.020  -18.847 1.00 51.75 ? 571 ASP D OD1 1 
ATOM   1712 O OD2 . ASP D 2 22 ? -19.317 96.387  -19.960 1.00 63.86 ? 571 ASP D OD2 1 
ATOM   1713 N N   . LEU D 2 23 ? -18.886 94.983  -14.581 1.00 48.49 ? 572 LEU D N   1 
ATOM   1714 C CA  . LEU D 2 23 ? -18.032 94.087  -13.808 1.00 46.25 ? 572 LEU D CA  1 
ATOM   1715 C C   . LEU D 2 23 ? -18.754 93.377  -12.689 1.00 46.84 ? 572 LEU D C   1 
ATOM   1716 O O   . LEU D 2 23 ? -18.476 92.209  -12.412 1.00 51.31 ? 572 LEU D O   1 
ATOM   1717 C CB  . LEU D 2 23 ? -16.859 94.826  -13.172 1.00 49.50 ? 572 LEU D CB  1 
ATOM   1718 C CG  . LEU D 2 23 ? -15.543 94.694  -13.916 1.00 59.40 ? 572 LEU D CG  1 
ATOM   1719 C CD1 . LEU D 2 23 ? -14.458 95.519  -13.194 1.00 52.77 ? 572 LEU D CD1 1 
ATOM   1720 C CD2 . LEU D 2 23 ? -15.168 93.222  -14.128 1.00 47.82 ? 572 LEU D CD2 1 
ATOM   1721 N N   . GLU D 2 24 ? -19.631 94.092  -11.991 1.00 40.94 ? 573 GLU D N   1 
ATOM   1722 C CA  . GLU D 2 24 ? -20.289 93.479  -10.852 1.00 47.60 ? 573 GLU D CA  1 
ATOM   1723 C C   . GLU D 2 24 ? -21.013 92.178  -11.207 1.00 50.90 ? 573 GLU D C   1 
ATOM   1724 O O   . GLU D 2 24 ? -20.926 91.236  -10.397 1.00 53.24 ? 573 GLU D O   1 
ATOM   1725 C CB  . GLU D 2 24 ? -21.206 94.522  -10.191 1.00 53.08 ? 573 GLU D CB  1 
ATOM   1726 C CG  . GLU D 2 24 ? -20.519 95.208  -9.002  1.00 49.25 ? 573 GLU D CG  1 
ATOM   1727 C CD  . GLU D 2 24 ? -21.435 96.100  -8.181  1.00 46.89 ? 573 GLU D CD  1 
ATOM   1728 O OE1 . GLU D 2 24 ? -22.639 95.798  -8.022  1.00 54.91 ? 573 GLU D OE1 1 
ATOM   1729 O OE2 . GLU D 2 24 ? -20.912 97.058  -7.591  1.00 51.59 ? 573 GLU D OE2 1 
ATOM   1730 N N   . PRO D 2 25 ? -21.667 92.026  -12.379 1.00 51.75 ? 574 PRO D N   1 
ATOM   1731 C CA  . PRO D 2 25 ? -22.161 90.693  -12.763 1.00 52.22 ? 574 PRO D CA  1 
ATOM   1732 C C   . PRO D 2 25 ? -21.048 89.759  -13.200 1.00 49.61 ? 574 PRO D C   1 
ATOM   1733 O O   . PRO D 2 25 ? -21.066 88.574  -12.848 1.00 46.18 ? 574 PRO D O   1 
ATOM   1734 C CB  . PRO D 2 25 ? -23.116 90.991  -13.925 1.00 42.20 ? 574 PRO D CB  1 
ATOM   1735 C CG  . PRO D 2 25 ? -23.541 92.365  -13.686 1.00 44.33 ? 574 PRO D CG  1 
ATOM   1736 C CD  . PRO D 2 25 ? -22.300 93.063  -13.203 1.00 47.69 ? 574 PRO D CD  1 
ATOM   1737 N N   . ARG D 2 26 ? -20.077 90.276  -13.971 1.00 44.19 ? 575 ARG D N   1 
ATOM   1738 C CA  . ARG D 2 26 ? -18.951 89.448  -14.394 1.00 49.30 ? 575 ARG D CA  1 
ATOM   1739 C C   . ARG D 2 26 ? -18.157 88.902  -13.219 1.00 46.75 ? 575 ARG D C   1 
ATOM   1740 O O   . ARG D 2 26 ? -17.351 87.989  -13.398 1.00 49.03 ? 575 ARG D O   1 
ATOM   1741 C CB  . ARG D 2 26 ? -18.002 90.212  -15.321 1.00 46.00 ? 575 ARG D CB  1 
ATOM   1742 C CG  . ARG D 2 26 ? -18.375 90.174  -16.780 1.00 39.42 ? 575 ARG D CG  1 
ATOM   1743 C CD  . ARG D 2 26 ? -17.518 91.141  -17.554 1.00 53.22 ? 575 ARG D CD  1 
ATOM   1744 N NE  . ARG D 2 26 ? -16.102 90.757  -17.558 1.00 60.61 ? 575 ARG D NE  1 
ATOM   1745 C CZ  . ARG D 2 26 ? -15.095 91.629  -17.629 1.00 66.40 ? 575 ARG D CZ  1 
ATOM   1746 N NH1 . ARG D 2 26 ? -15.362 92.933  -17.699 1.00 61.60 ? 575 ARG D NH1 1 
ATOM   1747 N NH2 . ARG D 2 26 ? -13.826 91.207  -17.626 1.00 60.01 ? 575 ARG D NH2 1 
ATOM   1748 N N   . PHE D 2 27 ? -18.358 89.450  -12.033 1.00 44.11 ? 576 PHE D N   1 
ATOM   1749 C CA  . PHE D 2 27 ? -17.750 88.937  -10.822 1.00 45.33 ? 576 PHE D CA  1 
ATOM   1750 C C   . PHE D 2 27 ? -18.737 88.188  -9.954  1.00 45.81 ? 576 PHE D C   1 
ATOM   1751 O O   . PHE D 2 27 ? -18.353 87.223  -9.287  1.00 51.02 ? 576 PHE D O   1 
ATOM   1752 C CB  . PHE D 2 27 ? -17.150 90.089  -10.016 1.00 48.59 ? 576 PHE D CB  1 
ATOM   1753 C CG  . PHE D 2 27 ? -16.536 89.675  -8.715  1.00 46.65 ? 576 PHE D CG  1 
ATOM   1754 C CD1 . PHE D 2 27 ? -15.197 89.351  -8.642  1.00 45.49 ? 576 PHE D CD1 1 
ATOM   1755 C CD2 . PHE D 2 27 ? -17.300 89.639  -7.551  1.00 55.70 ? 576 PHE D CD2 1 
ATOM   1756 C CE1 . PHE D 2 27 ? -14.624 88.981  -7.433  1.00 55.43 ? 576 PHE D CE1 1 
ATOM   1757 C CE2 . PHE D 2 27 ? -16.737 89.266  -6.333  1.00 54.91 ? 576 PHE D CE2 1 
ATOM   1758 C CZ  . PHE D 2 27 ? -15.398 88.937  -6.274  1.00 62.59 ? 576 PHE D CZ  1 
ATOM   1759 N N   . ASN D 2 28 ? -19.993 88.615  -9.944  1.00 46.33 ? 577 ASN D N   1 
ATOM   1760 C CA  . ASN D 2 28 ? -20.992 87.942  -9.125  1.00 53.72 ? 577 ASN D CA  1 
ATOM   1761 C C   . ASN D 2 28 ? -21.186 86.503  -9.581  1.00 52.58 ? 577 ASN D C   1 
ATOM   1762 O O   . ASN D 2 28 ? -21.042 85.562  -8.794  1.00 48.56 ? 577 ASN D O   1 
ATOM   1763 C CB  . ASN D 2 28 ? -22.304 88.712  -9.188  1.00 58.07 ? 577 ASN D CB  1 
ATOM   1764 C CG  . ASN D 2 28 ? -22.546 89.512  -7.939  1.00 65.21 ? 577 ASN D CG  1 
ATOM   1765 O OD1 . ASN D 2 28 ? -23.179 89.049  -6.990  1.00 71.94 ? 577 ASN D OD1 1 
ATOM   1766 N ND2 . ASN D 2 28 ? -22.003 90.721  -7.916  1.00 68.94 ? 577 ASN D ND2 1 
ATOM   1767 N N   . ASN D 2 29 ? -21.486 86.315  -10.869 1.00 52.49 ? 578 ASN D N   1 
ATOM   1768 C CA  . ASN D 2 29 ? -21.610 84.973  -11.421 1.00 53.17 ? 578 ASN D CA  1 
ATOM   1769 C C   . ASN D 2 29 ? -20.308 84.182  -11.302 1.00 56.69 ? 578 ASN D C   1 
ATOM   1770 O O   . ASN D 2 29 ? -20.319 82.953  -11.466 1.00 65.81 ? 578 ASN D O   1 
ATOM   1771 C CB  . ASN D 2 29 ? -22.103 85.051  -12.880 1.00 52.69 ? 578 ASN D CB  1 
ATOM   1772 C CG  . ASN D 2 29 ? -21.099 85.727  -13.832 1.00 67.86 ? 578 ASN D CG  1 
ATOM   1773 O OD1 . ASN D 2 29 ? -19.878 85.652  -13.644 1.00 67.67 ? 578 ASN D OD1 1 
ATOM   1774 N ND2 . ASN D 2 29 ? -21.625 86.410  -14.858 1.00 64.54 ? 578 ASN D ND2 1 
ATOM   1775 N N   . SER D 2 30 ? -19.191 84.852  -10.997 1.00 50.49 ? 579 SER D N   1 
ATOM   1776 C CA  . SER D 2 30 ? -17.934 84.138  -10.829 1.00 50.29 ? 579 SER D CA  1 
ATOM   1777 C C   . SER D 2 30 ? -17.725 83.659  -9.394  1.00 52.86 ? 579 SER D C   1 
ATOM   1778 O O   . SER D 2 30 ? -17.111 82.608  -9.194  1.00 50.91 ? 579 SER D O   1 
ATOM   1779 C CB  . SER D 2 30 ? -16.760 85.003  -11.278 1.00 50.27 ? 579 SER D CB  1 
ATOM   1780 O OG  . SER D 2 30 ? -15.567 84.639  -10.606 1.00 52.24 ? 579 SER D OG  1 
ATOM   1781 N N   . SER D 2 31 ? -18.209 84.386  -8.379  1.00 53.95 ? 580 SER D N   1 
ATOM   1782 C CA  . SER D 2 31 ? -18.297 83.757  -7.062  1.00 55.60 ? 580 SER D CA  1 
ATOM   1783 C C   . SER D 2 31 ? -19.115 82.476  -7.147  1.00 53.29 ? 580 SER D C   1 
ATOM   1784 O O   . SER D 2 31 ? -18.841 81.508  -6.426  1.00 44.72 ? 580 SER D O   1 
ATOM   1785 C CB  . SER D 2 31 ? -18.914 84.728  -6.039  1.00 51.74 ? 580 SER D CB  1 
ATOM   1786 O OG  . SER D 2 31 ? -17.943 85.562  -5.443  1.00 47.83 ? 580 SER D OG  1 
ATOM   1787 N N   . LEU D 2 32 ? -20.090 82.456  -8.056  1.00 57.77 ? 581 LEU D N   1 
ATOM   1788 C CA  . LEU D 2 32 ? -20.951 81.305  -8.267  1.00 60.42 ? 581 LEU D CA  1 
ATOM   1789 C C   . LEU D 2 32 ? -20.149 80.136  -8.831  1.00 53.53 ? 581 LEU D C   1 
ATOM   1790 O O   . LEU D 2 32 ? -20.168 79.032  -8.280  1.00 53.99 ? 581 LEU D O   1 
ATOM   1791 C CB  . LEU D 2 32 ? -22.115 81.714  -9.194  1.00 59.32 ? 581 LEU D CB  1 
ATOM   1792 C CG  . LEU D 2 32 ? -23.144 80.732  -9.770  1.00 71.27 ? 581 LEU D CG  1 
ATOM   1793 C CD1 . LEU D 2 32 ? -24.387 81.491  -10.189 1.00 68.12 ? 581 LEU D CD1 1 
ATOM   1794 C CD2 . LEU D 2 32 ? -22.611 79.955  -10.965 1.00 67.79 ? 581 LEU D CD2 1 
ATOM   1795 N N   . LYS D 2 33 ? -19.411 80.383  -9.919  1.00 51.70 ? 582 LYS D N   1 
ATOM   1796 C CA  . LYS D 2 33 ? -18.620 79.338  -10.566 1.00 49.43 ? 582 LYS D CA  1 
ATOM   1797 C C   . LYS D 2 33 ? -17.614 78.713  -9.613  1.00 50.30 ? 582 LYS D C   1 
ATOM   1798 O O   . LYS D 2 33 ? -17.385 77.496  -9.642  1.00 50.95 ? 582 LYS D O   1 
ATOM   1799 C CB  . LYS D 2 33 ? -17.906 79.934  -11.776 1.00 50.14 ? 582 LYS D CB  1 
ATOM   1800 C CG  . LYS D 2 33 ? -18.709 79.900  -13.037 1.00 46.78 ? 582 LYS D CG  1 
ATOM   1801 C CD  . LYS D 2 33 ? -19.121 78.479  -13.372 1.00 50.36 ? 582 LYS D CD  1 
ATOM   1802 C CE  . LYS D 2 33 ? -18.047 77.824  -14.232 1.00 48.37 ? 582 LYS D CE  1 
ATOM   1803 N NZ  . LYS D 2 33 ? -18.414 76.458  -14.722 1.00 62.00 ? 582 LYS D NZ  1 
ATOM   1804 N N   . ILE D 2 34 ? -16.987 79.533  -8.765  1.00 50.32 ? 583 ILE D N   1 
ATOM   1805 C CA  . ILE D 2 34 ? -16.124 79.020  -7.707  1.00 46.97 ? 583 ILE D CA  1 
ATOM   1806 C C   . ILE D 2 34 ? -16.846 77.931  -6.923  1.00 46.50 ? 583 ILE D C   1 
ATOM   1807 O O   . ILE D 2 34 ? -16.290 76.851  -6.692  1.00 52.18 ? 583 ILE D O   1 
ATOM   1808 C CB  . ILE D 2 34 ? -15.692 80.168  -6.782  1.00 54.86 ? 583 ILE D CB  1 
ATOM   1809 C CG1 . ILE D 2 34 ? -14.905 81.222  -7.549  1.00 53.02 ? 583 ILE D CG1 1 
ATOM   1810 C CG2 . ILE D 2 34 ? -14.875 79.630  -5.621  1.00 55.55 ? 583 ILE D CG2 1 
ATOM   1811 C CD1 . ILE D 2 34 ? -14.299 82.297  -6.653  1.00 61.01 ? 583 ILE D CD1 1 
ATOM   1812 N N   . GLU D 2 35 ? -18.089 78.189  -6.513  1.00 44.81 ? 584 GLU D N   1 
ATOM   1813 C CA  . GLU D 2 35 ? -18.844 77.228  -5.715  1.00 48.82 ? 584 GLU D CA  1 
ATOM   1814 C C   . GLU D 2 35 ? -19.524 76.123  -6.513  1.00 47.62 ? 584 GLU D C   1 
ATOM   1815 O O   . GLU D 2 35 ? -19.979 75.156  -5.903  1.00 51.95 ? 584 GLU D O   1 
ATOM   1816 C CB  . GLU D 2 35 ? -19.911 77.924  -4.861  1.00 58.28 ? 584 GLU D CB  1 
ATOM   1817 C CG  . GLU D 2 35 ? -19.403 78.600  -3.581  1.00 67.37 ? 584 GLU D CG  1 
ATOM   1818 C CD  . GLU D 2 35 ? -20.455 78.600  -2.455  1.00 76.53 ? 584 GLU D CD  1 
ATOM   1819 O OE1 . GLU D 2 35 ? -21.662 78.730  -2.765  1.00 80.71 ? 584 GLU D OE1 1 
ATOM   1820 O OE2 . GLU D 2 35 ? -20.083 78.430  -1.270  1.00 76.17 ? 584 GLU D OE2 1 
ATOM   1821 N N   . GLU D 2 36 ? -19.635 76.232  -7.842  1.00 49.15 ? 585 GLU D N   1 
ATOM   1822 C CA  . GLU D 2 36 ? -20.053 75.066  -8.625  1.00 45.65 ? 585 GLU D CA  1 
ATOM   1823 C C   . GLU D 2 36 ? -18.893 74.116  -8.876  1.00 48.47 ? 585 GLU D C   1 
ATOM   1824 O O   . GLU D 2 36 ? -19.082 72.893  -8.888  1.00 44.05 ? 585 GLU D O   1 
ATOM   1825 C CB  . GLU D 2 36 ? -20.628 75.472  -9.966  1.00 38.73 ? 585 GLU D CB  1 
ATOM   1826 C CG  . GLU D 2 36 ? -22.098 75.722  -9.999  1.00 42.80 ? 585 GLU D CG  1 
ATOM   1827 C CD  . GLU D 2 36 ? -22.548 75.947  -11.439 1.00 68.55 ? 585 GLU D CD  1 
ATOM   1828 O OE1 . GLU D 2 36 ? -22.215 75.093  -12.305 1.00 65.32 ? 585 GLU D OE1 1 
ATOM   1829 O OE2 . GLU D 2 36 ? -23.208 76.981  -11.716 1.00 67.52 ? 585 GLU D OE2 1 
ATOM   1830 N N   . LEU D 2 37 ? -17.697 74.664  -9.101  1.00 52.87 ? 586 LEU D N   1 
ATOM   1831 C CA  . LEU D 2 37 ? -16.515 73.825  -9.291  1.00 52.28 ? 586 LEU D CA  1 
ATOM   1832 C C   . LEU D 2 37 ? -16.087 73.169  -7.987  1.00 47.37 ? 586 LEU D C   1 
ATOM   1833 O O   . LEU D 2 37 ? -15.626 72.025  -7.981  1.00 47.44 ? 586 LEU D O   1 
ATOM   1834 C CB  . LEU D 2 37 ? -15.380 74.659  -9.883  1.00 52.69 ? 586 LEU D CB  1 
ATOM   1835 C CG  . LEU D 2 37 ? -15.671 75.196  -11.281 1.00 50.58 ? 586 LEU D CG  1 
ATOM   1836 C CD1 . LEU D 2 37 ? -14.835 76.428  -11.584 1.00 56.52 ? 586 LEU D CD1 1 
ATOM   1837 C CD2 . LEU D 2 37 ? -15.421 74.116  -12.299 1.00 52.95 ? 586 LEU D CD2 1 
ATOM   1838 N N   . GLN D 2 38 ? -16.243 73.857  -6.859  1.00 48.63 ? 587 GLN D N   1 
ATOM   1839 C CA  . GLN D 2 38 ? -15.889 73.251  -5.589  1.00 51.18 ? 587 GLN D CA  1 
ATOM   1840 C C   . GLN D 2 38 ? -16.830 72.095  -5.236  1.00 49.54 ? 587 GLN D C   1 
ATOM   1841 O O   . GLN D 2 38 ? -16.390 71.053  -4.743  1.00 44.11 ? 587 GLN D O   1 
ATOM   1842 C CB  . GLN D 2 38 ? -15.870 74.321  -4.498  1.00 56.24 ? 587 GLN D CB  1 
ATOM   1843 C CG  . GLN D 2 38 ? -14.605 75.180  -4.546  1.00 58.90 ? 587 GLN D CG  1 
ATOM   1844 C CD  . GLN D 2 38 ? -14.553 76.234  -3.462  1.00 68.09 ? 587 GLN D CD  1 
ATOM   1845 O OE1 . GLN D 2 38 ? -13.700 76.180  -2.566  1.00 75.41 ? 587 GLN D OE1 1 
ATOM   1846 N NE2 . GLN D 2 38 ? -15.457 77.219  -3.546  1.00 62.66 ? 587 GLN D NE2 1 
ATOM   1847 N N   . GLU D 2 39 ? -18.129 72.270  -5.512  1.00 49.63 ? 588 GLU D N   1 
ATOM   1848 C CA  . GLU D 2 39 ? -19.086 71.180  -5.307  1.00 47.57 ? 588 GLU D CA  1 
ATOM   1849 C C   . GLU D 2 39 ? -18.771 69.997  -6.195  1.00 49.36 ? 588 GLU D C   1 
ATOM   1850 O O   . GLU D 2 39 ? -18.794 68.842  -5.733  1.00 55.19 ? 588 GLU D O   1 
ATOM   1851 C CB  . GLU D 2 39 ? -20.509 71.669  -5.568  1.00 49.25 ? 588 GLU D CB  1 
ATOM   1852 C CG  . GLU D 2 39 ? -21.557 70.557  -5.537  1.00 54.31 ? 588 GLU D CG  1 
ATOM   1853 C CD  . GLU D 2 39 ? -21.732 69.908  -4.174  1.00 65.51 ? 588 GLU D CD  1 
ATOM   1854 O OE1 . GLU D 2 39 ? -21.313 70.509  -3.155  1.00 63.64 ? 588 GLU D OE1 1 
ATOM   1855 O OE2 . GLU D 2 39 ? -22.272 68.774  -4.121  1.00 69.61 ? 588 GLU D OE2 1 
ATOM   1856 N N   . ALA D 2 40 ? -18.471 70.246  -7.479  1.00 44.56 ? 589 ALA D N   1 
ATOM   1857 C CA  . ALA D 2 40 ? -18.169 69.162  -8.408  1.00 44.26 ? 589 ALA D CA  1 
ATOM   1858 C C   . ALA D 2 40 ? -16.881 68.451  -8.028  1.00 43.82 ? 589 ALA D C   1 
ATOM   1859 O O   . ALA D 2 40 ? -16.779 67.225  -8.146  1.00 45.55 ? 589 ALA D O   1 
ATOM   1860 C CB  . ALA D 2 40 ? -18.068 69.684  -9.835  1.00 43.64 ? 589 ALA D CB  1 
ATOM   1861 N N   . LEU D 2 41 ? -15.897 69.213  -7.561  1.00 38.52 ? 590 LEU D N   1 
ATOM   1862 C CA  . LEU D 2 41 ? -14.649 68.627  -7.101  1.00 39.19 ? 590 LEU D CA  1 
ATOM   1863 C C   . LEU D 2 41 ? -14.878 67.698  -5.906  1.00 46.36 ? 590 LEU D C   1 
ATOM   1864 O O   . LEU D 2 41 ? -14.308 66.599  -5.843  1.00 45.14 ? 590 LEU D O   1 
ATOM   1865 C CB  . LEU D 2 41 ? -13.682 69.756  -6.756  1.00 42.06 ? 590 LEU D CB  1 
ATOM   1866 C CG  . LEU D 2 41 ? -12.193 69.470  -6.700  1.00 42.05 ? 590 LEU D CG  1 
ATOM   1867 C CD1 . LEU D 2 41 ? -11.854 68.497  -7.803  1.00 39.58 ? 590 LEU D CD1 1 
ATOM   1868 C CD2 . LEU D 2 41 ? -11.430 70.769  -6.860  1.00 33.31 ? 590 LEU D CD2 1 
ATOM   1869 N N   . ARG D 2 42 ? -15.728 68.106  -4.949  1.00 46.66 ? 591 ARG D N   1 
ATOM   1870 C CA  . ARG D 2 42 ? -15.981 67.236  -3.804  1.00 44.08 ? 591 ARG D CA  1 
ATOM   1871 C C   . ARG D 2 42 ? -16.783 66.007  -4.210  1.00 46.19 ? 591 ARG D C   1 
ATOM   1872 O O   . ARG D 2 42 ? -16.544 64.911  -3.691  1.00 46.78 ? 591 ARG D O   1 
ATOM   1873 C CB  . ARG D 2 42 ? -16.716 67.975  -2.690  1.00 49.54 ? 591 ARG D CB  1 
ATOM   1874 C CG  . ARG D 2 42 ? -17.736 67.077  -2.015  1.00 51.47 ? 591 ARG D CG  1 
ATOM   1875 C CD  . ARG D 2 42 ? -18.263 67.623  -0.732  1.00 50.94 ? 591 ARG D CD  1 
ATOM   1876 N NE  . ARG D 2 42 ? -19.626 67.155  -0.556  1.00 63.27 ? 591 ARG D NE  1 
ATOM   1877 C CZ  . ARG D 2 42 ? -20.681 67.805  -1.034  1.00 72.56 ? 591 ARG D CZ  1 
ATOM   1878 N NH1 . ARG D 2 42 ? -20.496 68.932  -1.705  1.00 69.29 ? 591 ARG D NH1 1 
ATOM   1879 N NH2 . ARG D 2 42 ? -21.914 67.343  -0.847  1.00 74.94 ? 591 ARG D NH2 1 
ATOM   1880 N N   . LYS D 2 43 ? -17.751 66.168  -5.121  1.00 45.50 ? 592 LYS D N   1 
ATOM   1881 C CA  . LYS D 2 43 ? -18.506 65.011  -5.599  1.00 44.02 ? 592 LYS D CA  1 
ATOM   1882 C C   . LYS D 2 43 ? -17.590 64.009  -6.286  1.00 41.40 ? 592 LYS D C   1 
ATOM   1883 O O   . LYS D 2 43 ? -17.637 62.807  -6.001  1.00 38.14 ? 592 LYS D O   1 
ATOM   1884 C CB  . LYS D 2 43 ? -19.622 65.461  -6.539  1.00 44.82 ? 592 LYS D CB  1 
ATOM   1885 C CG  . LYS D 2 43 ? -21.005 65.179  -5.976  1.00 56.58 ? 592 LYS D CG  1 
ATOM   1886 C CD  . LYS D 2 43 ? -21.086 65.674  -4.520  1.00 58.23 ? 592 LYS D CD  1 
ATOM   1887 C CE  . LYS D 2 43 ? -22.248 65.027  -3.781  1.00 62.00 ? 592 LYS D CE  1 
ATOM   1888 N NZ  . LYS D 2 43 ? -21.979 64.859  -2.324  1.00 65.12 ? 592 LYS D NZ  1 
ATOM   1889 N N   . LYS D 2 44 ? -16.723 64.497  -7.177  1.00 41.98 ? 593 LYS D N   1 
ATOM   1890 C CA  . LYS D 2 44 ? -15.782 63.616  -7.859  1.00 44.16 ? 593 LYS D CA  1 
ATOM   1891 C C   . LYS D 2 44 ? -14.814 62.974  -6.874  1.00 45.00 ? 593 LYS D C   1 
ATOM   1892 O O   . LYS D 2 44 ? -14.520 61.773  -6.964  1.00 40.37 ? 593 LYS D O   1 
ATOM   1893 C CB  . LYS D 2 44 ? -15.014 64.399  -8.924  1.00 45.02 ? 593 LYS D CB  1 
ATOM   1894 N N   . GLU D 2 45 ? -14.297 63.759  -5.938  1.00 44.04 ? 594 GLU D N   1 
ATOM   1895 C CA  . GLU D 2 45 ? -13.433 63.183  -4.922  1.00 44.05 ? 594 GLU D CA  1 
ATOM   1896 C C   . GLU D 2 45 ? -14.158 62.104  -4.130  1.00 40.62 ? 594 GLU D C   1 
ATOM   1897 O O   . GLU D 2 45 ? -13.512 61.171  -3.643  1.00 47.63 ? 594 GLU D O   1 
ATOM   1898 C CB  . GLU D 2 45 ? -12.902 64.295  -4.026  1.00 49.33 ? 594 GLU D CB  1 
ATOM   1899 C CG  . GLU D 2 45 ? -11.457 64.648  -4.315  1.00 54.07 ? 594 GLU D CG  1 
ATOM   1900 C CD  . GLU D 2 45 ? -11.123 66.128  -4.074  1.00 62.70 ? 594 GLU D CD  1 
ATOM   1901 O OE1 . GLU D 2 45 ? -10.211 66.644  -4.771  1.00 57.72 ? 594 GLU D OE1 1 
ATOM   1902 O OE2 . GLU D 2 45 ? -11.790 66.780  -3.229  1.00 55.47 ? 594 GLU D OE2 1 
ATOM   1903 N N   . GLU D 2 46 ? -15.491 62.171  -4.036  1.00 37.82 ? 595 GLU D N   1 
ATOM   1904 C CA  . GLU D 2 46 ? -16.225 61.101  -3.369  1.00 41.64 ? 595 GLU D CA  1 
ATOM   1905 C C   . GLU D 2 46 ? -16.342 59.864  -4.252  1.00 40.09 ? 595 GLU D C   1 
ATOM   1906 O O   . GLU D 2 46 ? -15.958 58.762  -3.849  1.00 36.44 ? 595 GLU D O   1 
ATOM   1907 C CB  . GLU D 2 46 ? -17.624 61.553  -2.942  1.00 42.72 ? 595 GLU D CB  1 
ATOM   1908 C CG  . GLU D 2 46 ? -17.678 62.605  -1.825  1.00 53.75 ? 595 GLU D CG  1 
ATOM   1909 C CD  . GLU D 2 46 ? -16.605 62.430  -0.725  1.00 63.51 ? 595 GLU D CD  1 
ATOM   1910 O OE1 . GLU D 2 46 ? -16.718 61.490  0.094   1.00 72.06 ? 595 GLU D OE1 1 
ATOM   1911 O OE2 . GLU D 2 46 ? -15.681 63.292  -0.658  1.00 56.76 ? 595 GLU D OE2 1 
ATOM   1912 N N   . GLU D 2 47 ? -16.885 60.042  -5.463  1.00 40.19 ? 596 GLU D N   1 
ATOM   1913 C CA  . GLU D 2 47 ? -17.108 58.932  -6.389  1.00 38.65 ? 596 GLU D CA  1 
ATOM   1914 C C   . GLU D 2 47 ? -15.842 58.156  -6.711  1.00 34.07 ? 596 GLU D C   1 
ATOM   1915 O O   . GLU D 2 47 ? -15.919 57.013  -7.169  1.00 31.37 ? 596 GLU D O   1 
ATOM   1916 C CB  . GLU D 2 47 ? -17.705 59.451  -7.688  1.00 39.80 ? 596 GLU D CB  1 
ATOM   1917 C CG  . GLU D 2 47 ? -18.870 60.390  -7.539  1.00 43.92 ? 596 GLU D CG  1 
ATOM   1918 C CD  . GLU D 2 47 ? -19.185 61.082  -8.848  1.00 48.63 ? 596 GLU D CD  1 
ATOM   1919 O OE1 . GLU D 2 47 ? -18.274 61.151  -9.711  1.00 47.00 ? 596 GLU D OE1 1 
ATOM   1920 O OE2 . GLU D 2 47 ? -20.351 61.488  -9.039  1.00 40.52 ? 596 GLU D OE2 1 
ATOM   1921 N N   . MET D 2 48 ? -14.675 58.757  -6.535  1.00 36.91 ? 597 MET D N   1 
ATOM   1922 C CA  . MET D 2 48 ? -13.470 57.953  -6.649  1.00 35.98 ? 597 MET D CA  1 
ATOM   1923 C C   . MET D 2 48 ? -13.185 57.223  -5.351  1.00 39.46 ? 597 MET D C   1 
ATOM   1924 O O   . MET D 2 48 ? -12.798 56.046  -5.368  1.00 41.60 ? 597 MET D O   1 
ATOM   1925 C CB  . MET D 2 48 ? -12.284 58.811  -7.031  1.00 34.62 ? 597 MET D CB  1 
ATOM   1926 C CG  . MET D 2 48 ? -11.152 58.010  -7.535  1.00 25.57 ? 597 MET D CG  1 
ATOM   1927 S SD  . MET D 2 48 ? -9.765  59.129  -7.528  1.00 60.97 ? 597 MET D SD  1 
ATOM   1928 C CE  . MET D 2 48 ? -8.543  58.084  -8.319  1.00 47.02 ? 597 MET D CE  1 
ATOM   1929 N N   . LYS D 2 49 ? -13.364 57.902  -4.213  1.00 34.89 ? 598 LYS D N   1 
ATOM   1930 C CA  . LYS D 2 49 ? -13.210 57.199  -2.949  1.00 39.31 ? 598 LYS D CA  1 
ATOM   1931 C C   . LYS D 2 49 ? -14.018 55.894  -2.950  1.00 40.22 ? 598 LYS D C   1 
ATOM   1932 O O   . LYS D 2 49 ? -13.524 54.839  -2.547  1.00 37.17 ? 598 LYS D O   1 
ATOM   1933 C CB  . LYS D 2 49 ? -13.621 58.092  -1.779  1.00 38.12 ? 598 LYS D CB  1 
ATOM   1934 C CG  . LYS D 2 49 ? -12.458 58.578  -0.929  1.00 39.23 ? 598 LYS D CG  1 
ATOM   1935 C CD  . LYS D 2 49 ? -12.935 59.264  0.367   1.00 45.50 ? 598 LYS D CD  1 
ATOM   1936 C CE  . LYS D 2 49 ? -13.094 60.789  0.196   1.00 47.85 ? 598 LYS D CE  1 
ATOM   1937 N NZ  . LYS D 2 49 ? -11.826 61.565  0.017   1.00 41.88 ? 598 LYS D NZ  1 
ATOM   1938 N N   . GLN D 2 50 ? -15.252 55.938  -3.454  1.00 36.56 ? 599 GLN D N   1 
ATOM   1939 C CA  . GLN D 2 50 ? -16.087 54.751  -3.401  1.00 37.12 ? 599 GLN D CA  1 
ATOM   1940 C C   . GLN D 2 50 ? -15.798 53.787  -4.538  1.00 39.92 ? 599 GLN D C   1 
ATOM   1941 O O   . GLN D 2 50 ? -15.807 52.569  -4.335  1.00 42.01 ? 599 GLN D O   1 
ATOM   1942 C CB  . GLN D 2 50 ? -17.562 55.107  -3.452  1.00 43.62 ? 599 GLN D CB  1 
ATOM   1943 C CG  . GLN D 2 50 ? -18.014 56.237  -2.608  1.00 41.98 ? 599 GLN D CG  1 
ATOM   1944 C CD  . GLN D 2 50 ? -19.093 56.964  -3.348  1.00 50.63 ? 599 GLN D CD  1 
ATOM   1945 O OE1 . GLN D 2 50 ? -19.722 56.376  -4.243  1.00 55.94 ? 599 GLN D OE1 1 
ATOM   1946 N NE2 . GLN D 2 50 ? -19.333 58.228  -3.000  1.00 45.06 ? 599 GLN D NE2 1 
ATOM   1947 N N   . MET D 2 51 ? -15.638 54.296  -5.757  1.00 36.79 ? 600 MET D N   1 
ATOM   1948 C CA  . MET D 2 51 ? -15.199 53.423  -6.830  1.00 33.54 ? 600 MET D CA  1 
ATOM   1949 C C   . MET D 2 51 ? -14.004 52.609  -6.387  1.00 34.70 ? 600 MET D C   1 
ATOM   1950 O O   . MET D 2 51 ? -13.997 51.384  -6.552  1.00 35.81 ? 600 MET D O   1 
ATOM   1951 C CB  . MET D 2 51 ? -14.872 54.237  -8.073  1.00 38.89 ? 600 MET D CB  1 
ATOM   1952 C CG  . MET D 2 51 ? -13.980 53.529  -9.068  1.00 44.56 ? 600 MET D CG  1 
ATOM   1953 S SD  . MET D 2 51 ? -14.103 54.269  -10.698 1.00 51.05 ? 600 MET D SD  1 
ATOM   1954 C CE  . MET D 2 51 ? -15.884 54.132  -10.884 1.00 53.29 ? 600 MET D CE  1 
ATOM   1955 N N   . GLU D 2 52 ? -13.001 53.250  -5.781  1.00 33.17 ? 601 GLU D N   1 
ATOM   1956 C CA  . GLU D 2 52 ? -11.849 52.479  -5.324  1.00 35.84 ? 601 GLU D CA  1 
ATOM   1957 C C   . GLU D 2 52 ? -12.230 51.424  -4.288  1.00 36.55 ? 601 GLU D C   1 
ATOM   1958 O O   . GLU D 2 52 ? -11.836 50.261  -4.410  1.00 33.55 ? 601 GLU D O   1 
ATOM   1959 C CB  . GLU D 2 52 ? -10.728 53.378  -4.805  1.00 33.13 ? 601 GLU D CB  1 
ATOM   1960 C CG  . GLU D 2 52 ? -9.402  52.813  -5.285  1.00 36.15 ? 601 GLU D CG  1 
ATOM   1961 C CD  . GLU D 2 52 ? -8.191  53.359  -4.599  1.00 41.36 ? 601 GLU D CD  1 
ATOM   1962 O OE1 . GLU D 2 52 ? -8.312  54.452  -4.000  1.00 49.11 ? 601 GLU D OE1 1 
ATOM   1963 O OE2 . GLU D 2 52 ? -7.136  52.671  -4.642  1.00 36.24 ? 601 GLU D OE2 1 
ATOM   1964 N N   . GLU D 2 53 ? -12.996 51.807  -3.265  1.00 37.19 ? 602 GLU D N   1 
ATOM   1965 C CA  . GLU D 2 53 ? -13.380 50.846  -2.235  1.00 35.85 ? 602 GLU D CA  1 
ATOM   1966 C C   . GLU D 2 53 ? -14.241 49.723  -2.814  1.00 37.21 ? 602 GLU D C   1 
ATOM   1967 O O   . GLU D 2 53 ? -14.180 48.584  -2.338  1.00 36.91 ? 602 GLU D O   1 
ATOM   1968 C CB  . GLU D 2 53 ? -14.109 51.576  -1.107  1.00 38.48 ? 602 GLU D CB  1 
ATOM   1969 C CG  . GLU D 2 53 ? -13.248 52.612  -0.373  1.00 52.30 ? 602 GLU D CG  1 
ATOM   1970 C CD  . GLU D 2 53 ? -11.964 52.049  0.234   1.00 55.99 ? 602 GLU D CD  1 
ATOM   1971 O OE1 . GLU D 2 53 ? -12.021 50.953  0.829   1.00 55.07 ? 602 GLU D OE1 1 
ATOM   1972 O OE2 . GLU D 2 53 ? -10.899 52.698  0.111   1.00 63.72 ? 602 GLU D OE2 1 
ATOM   1973 N N   . ARG D 2 54 ? -15.042 50.022  -3.842  1.00 36.05 ? 603 ARG D N   1 
ATOM   1974 C CA  . ARG D 2 54 ? -15.770 48.992  -4.584  1.00 32.82 ? 603 ARG D CA  1 
ATOM   1975 C C   . ARG D 2 54 ? -14.830 48.078  -5.363  1.00 37.66 ? 603 ARG D C   1 
ATOM   1976 O O   . ARG D 2 54 ? -15.121 46.896  -5.541  1.00 40.40 ? 603 ARG D O   1 
ATOM   1977 C CB  . ARG D 2 54 ? -16.758 49.645  -5.558  1.00 34.21 ? 603 ARG D CB  1 
ATOM   1978 C CG  . ARG D 2 54 ? -18.204 49.674  -5.089  1.00 36.64 ? 603 ARG D CG  1 
ATOM   1979 C CD  . ARG D 2 54 ? -19.118 50.443  -6.045  1.00 38.03 ? 603 ARG D CD  1 
ATOM   1980 N NE  . ARG D 2 54 ? -19.058 51.885  -5.796  1.00 51.56 ? 603 ARG D NE  1 
ATOM   1981 C CZ  . ARG D 2 54 ? -19.104 52.822  -6.746  1.00 55.25 ? 603 ARG D CZ  1 
ATOM   1982 N NH1 . ARG D 2 54 ? -19.222 52.463  -8.020  1.00 57.83 ? 603 ARG D NH1 1 
ATOM   1983 N NH2 . ARG D 2 54 ? -19.031 54.118  -6.426  1.00 48.26 ? 603 ARG D NH2 1 
ATOM   1984 N N   . TYR D 2 55 ? -13.723 48.608  -5.868  1.00 39.91 ? 604 TYR D N   1 
ATOM   1985 C CA  . TYR D 2 55 ? -12.774 47.792  -6.609  1.00 35.31 ? 604 TYR D CA  1 
ATOM   1986 C C   . TYR D 2 55 ? -11.882 46.972  -5.690  1.00 36.94 ? 604 TYR D C   1 
ATOM   1987 O O   . TYR D 2 55 ? -11.468 45.867  -6.053  1.00 37.19 ? 604 TYR D O   1 
ATOM   1988 C CB  . TYR D 2 55 ? -11.917 48.671  -7.521  1.00 38.06 ? 604 TYR D CB  1 
ATOM   1989 C CG  . TYR D 2 55 ? -12.482 48.943  -8.899  1.00 39.00 ? 604 TYR D CG  1 
ATOM   1990 C CD1 . TYR D 2 55 ? -12.537 47.928  -9.845  1.00 38.69 ? 604 TYR D CD1 1 
ATOM   1991 C CD2 . TYR D 2 55 ? -12.922 50.205  -9.269  1.00 34.14 ? 604 TYR D CD2 1 
ATOM   1992 C CE1 . TYR D 2 55 ? -13.023 48.159  -11.112 1.00 40.79 ? 604 TYR D CE1 1 
ATOM   1993 C CE2 . TYR D 2 55 ? -13.404 50.450  -10.531 1.00 40.30 ? 604 TYR D CE2 1 
ATOM   1994 C CZ  . TYR D 2 55 ? -13.462 49.420  -11.454 1.00 48.24 ? 604 TYR D CZ  1 
ATOM   1995 O OH  . TYR D 2 55 ? -13.952 49.638  -12.729 1.00 50.61 ? 604 TYR D OH  1 
ATOM   1996 N N   . LYS D 2 56 ? -11.540 47.508  -4.513  1.00 38.34 ? 605 LYS D N   1 
ATOM   1997 C CA  . LYS D 2 56 ? -10.736 46.730  -3.580  1.00 37.04 ? 605 LYS D CA  1 
ATOM   1998 C C   . LYS D 2 56 ? -11.522 45.550  -3.033  1.00 37.37 ? 605 LYS D C   1 
ATOM   1999 O O   . LYS D 2 56 ? -10.950 44.481  -2.775  1.00 32.44 ? 605 LYS D O   1 
ATOM   2000 C CB  . LYS D 2 56 ? -10.222 47.610  -2.439  1.00 35.70 ? 605 LYS D CB  1 
ATOM   2001 C CG  . LYS D 2 56 ? -9.373  48.812  -2.854  1.00 38.70 ? 605 LYS D CG  1 
ATOM   2002 C CD  . LYS D 2 56 ? -8.850  49.537  -1.601  1.00 45.49 ? 605 LYS D CD  1 
ATOM   2003 C CE  . LYS D 2 56 ? -8.900  51.092  -1.719  1.00 46.32 ? 605 LYS D CE  1 
ATOM   2004 N NZ  . LYS D 2 56 ? -8.145  51.774  -0.596  1.00 41.74 ? 605 LYS D NZ  1 
ATOM   2005 N N   . LYS D 2 57 ? -12.839 45.709  -2.873  1.00 39.42 ? 606 LYS D N   1 
ATOM   2006 C CA  . LYS D 2 57 ? -13.619 44.631  -2.289  1.00 35.97 ? 606 LYS D CA  1 
ATOM   2007 C C   . LYS D 2 57 ? -13.821 43.479  -3.257  1.00 34.52 ? 606 LYS D C   1 
ATOM   2008 O O   . LYS D 2 57 ? -13.596 42.326  -2.894  1.00 37.49 ? 606 LYS D O   1 
ATOM   2009 C CB  . LYS D 2 57 ? -14.955 45.146  -1.745  1.00 31.13 ? 606 LYS D CB  1 
ATOM   2010 C CG  . LYS D 2 57 ? -14.855 45.608  -0.275  1.00 30.89 ? 606 LYS D CG  1 
ATOM   2011 C CD  . LYS D 2 57 ? -15.408 44.492  0.654   1.00 43.03 ? 606 LYS D CD  1 
ATOM   2012 C CE  . LYS D 2 57 ? -14.503 43.209  0.645   1.00 52.73 ? 606 LYS D CE  1 
ATOM   2013 N NZ  . LYS D 2 57 ? -14.957 42.001  1.425   1.00 44.37 ? 606 LYS D NZ  1 
ATOM   2014 N N   . TYR D 2 58 ? -14.213 43.759  -4.493  1.00 32.93 ? 607 TYR D N   1 
ATOM   2015 C CA  . TYR D 2 58 ? -14.309 42.684  -5.473  1.00 38.15 ? 607 TYR D CA  1 
ATOM   2016 C C   . TYR D 2 58 ? -12.982 41.939  -5.616  1.00 37.01 ? 607 TYR D C   1 
ATOM   2017 O O   . TYR D 2 58 ? -12.969 40.715  -5.807  1.00 33.10 ? 607 TYR D O   1 
ATOM   2018 C CB  . TYR D 2 58 ? -14.794 43.282  -6.792  1.00 42.44 ? 607 TYR D CB  1 
ATOM   2019 C CG  . TYR D 2 58 ? -16.295 43.484  -6.748  1.00 56.72 ? 607 TYR D CG  1 
ATOM   2020 C CD1 . TYR D 2 58 ? -16.897 44.659  -7.223  1.00 55.68 ? 607 TYR D CD1 1 
ATOM   2021 C CD2 . TYR D 2 58 ? -17.118 42.487  -6.217  1.00 53.40 ? 607 TYR D CD2 1 
ATOM   2022 C CE1 . TYR D 2 58 ? -18.289 44.825  -7.161  1.00 66.31 ? 607 TYR D CE1 1 
ATOM   2023 C CE2 . TYR D 2 58 ? -18.495 42.636  -6.157  1.00 61.21 ? 607 TYR D CE2 1 
ATOM   2024 C CZ  . TYR D 2 58 ? -19.082 43.800  -6.629  1.00 79.58 ? 607 TYR D CZ  1 
ATOM   2025 O OH  . TYR D 2 58 ? -20.461 43.906  -6.553  1.00 81.88 ? 607 TYR D OH  1 
ATOM   2026 N N   . LEU D 2 59 ? -11.864 42.657  -5.471  1.00 36.20 ? 608 LEU D N   1 
ATOM   2027 C CA  . LEU D 2 59 ? -10.536 42.051  -5.462  1.00 29.76 ? 608 LEU D CA  1 
ATOM   2028 C C   . LEU D 2 59 ? -10.385 41.031  -4.335  1.00 34.01 ? 608 LEU D C   1 
ATOM   2029 O O   . LEU D 2 59 ? -9.798  39.962  -4.534  1.00 34.85 ? 608 LEU D O   1 
ATOM   2030 C CB  . LEU D 2 59 ? -9.500  43.167  -5.343  1.00 32.18 ? 608 LEU D CB  1 
ATOM   2031 C CG  . LEU D 2 59 ? -8.016  43.035  -5.674  1.00 35.65 ? 608 LEU D CG  1 
ATOM   2032 C CD1 . LEU D 2 59 ? -7.382  44.427  -5.775  1.00 38.48 ? 608 LEU D CD1 1 
ATOM   2033 C CD2 . LEU D 2 59 ? -7.302  42.231  -4.597  1.00 36.50 ? 608 LEU D CD2 1 
ATOM   2034 N N   . GLU D 2 60 ? -10.875 41.351  -3.128  1.00 35.79 ? 609 GLU D N   1 
ATOM   2035 C CA  . GLU D 2 60 ? -10.781 40.369  -2.046  1.00 32.33 ? 609 GLU D CA  1 
ATOM   2036 C C   . GLU D 2 60 ? -11.778 39.251  -2.252  1.00 28.69 ? 609 GLU D C   1 
ATOM   2037 O O   . GLU D 2 60 ? -11.525 38.122  -1.836  1.00 34.11 ? 609 GLU D O   1 
ATOM   2038 C CB  . GLU D 2 60 ? -11.008 40.990  -0.651  1.00 34.34 ? 609 GLU D CB  1 
ATOM   2039 C CG  . GLU D 2 60 ? -10.091 42.136  -0.191  1.00 33.94 ? 609 GLU D CG  1 
ATOM   2040 C CD  . GLU D 2 60 ? -8.655  41.723  0.159   1.00 38.33 ? 609 GLU D CD  1 
ATOM   2041 O OE1 . GLU D 2 60 ? -7.893  41.377  -0.766  1.00 39.81 ? 609 GLU D OE1 1 
ATOM   2042 O OE2 . GLU D 2 60 ? -8.285  41.739  1.360   1.00 46.50 ? 609 GLU D OE2 1 
ATOM   2043 N N   . LYS D 2 61 ? -12.933 39.557  -2.848  1.00 29.16 ? 610 LYS D N   1 
ATOM   2044 C CA  . LYS D 2 61 ? -13.933 38.539  -3.155  1.00 28.85 ? 610 LYS D CA  1 
ATOM   2045 C C   . LYS D 2 61 ? -13.435 37.585  -4.236  1.00 27.81 ? 610 LYS D C   1 
ATOM   2046 O O   . LYS D 2 61 ? -13.882 36.438  -4.326  1.00 24.58 ? 610 LYS D O   1 
ATOM   2047 C CB  . LYS D 2 61 ? -15.214 39.219  -3.622  1.00 31.78 ? 610 LYS D CB  1 
ATOM   2048 C CG  . LYS D 2 61 ? -16.005 39.998  -2.582  1.00 32.40 ? 610 LYS D CG  1 
ATOM   2049 C CD  . LYS D 2 61 ? -17.172 40.688  -3.305  1.00 38.72 ? 610 LYS D CD  1 
ATOM   2050 C CE  . LYS D 2 61 ? -18.480 40.665  -2.551  1.00 35.09 ? 610 LYS D CE  1 
ATOM   2051 N NZ  . LYS D 2 61 ? -19.594 41.142  -3.407  1.00 35.84 ? 610 LYS D NZ  1 
ATOM   2052 N N   . ALA D 2 62 ? -12.538 38.067  -5.083  1.00 28.12 ? 611 ALA D N   1 
ATOM   2053 C CA  . ALA D 2 62 ? -11.909 37.223  -6.075  1.00 21.25 ? 611 ALA D CA  1 
ATOM   2054 C C   . ALA D 2 62 ? -10.910 36.286  -5.422  1.00 23.08 ? 611 ALA D C   1 
ATOM   2055 O O   . ALA D 2 62 ? -10.928 35.077  -5.673  1.00 26.62 ? 611 ALA D O   1 
ATOM   2056 C CB  . ALA D 2 62 ? -11.229 38.100  -7.120  1.00 22.55 ? 611 ALA D CB  1 
ATOM   2057 N N   . LYS D 2 63 ? -10.024 36.824  -4.583  1.00 21.00 ? 612 LYS D N   1 
ATOM   2058 C CA  . LYS D 2 63 ? -9.004  35.982  -3.959  1.00 25.17 ? 612 LYS D CA  1 
ATOM   2059 C C   . LYS D 2 63 ? -9.628  34.916  -3.071  1.00 28.63 ? 612 LYS D C   1 
ATOM   2060 O O   . LYS D 2 63 ? -9.064  33.829  -2.897  1.00 30.63 ? 612 LYS D O   1 
ATOM   2061 C CB  . LYS D 2 63 ? -8.043  36.812  -3.121  1.00 28.33 ? 612 LYS D CB  1 
ATOM   2062 C CG  . LYS D 2 63 ? -7.357  37.937  -3.820  1.00 34.12 ? 612 LYS D CG  1 
ATOM   2063 C CD  . LYS D 2 63 ? -6.634  38.733  -2.768  1.00 37.62 ? 612 LYS D CD  1 
ATOM   2064 C CE  . LYS D 2 63 ? -5.425  39.416  -3.306  1.00 38.91 ? 612 LYS D CE  1 
ATOM   2065 N NZ  . LYS D 2 63 ? -4.225  38.992  -2.491  1.00 39.44 ? 612 LYS D NZ  1 
ATOM   2066 N N   . SER D 2 64 ? -10.768 35.227  -2.474  1.00 24.92 ? 613 SER D N   1 
ATOM   2067 C CA  . SER D 2 64 ? -11.405 34.267  -1.595  1.00 26.53 ? 613 SER D CA  1 
ATOM   2068 C C   . SER D 2 64 ? -11.978 33.114  -2.406  1.00 29.49 ? 613 SER D C   1 
ATOM   2069 O O   . SER D 2 64 ? -11.813 31.942  -2.050  1.00 30.94 ? 613 SER D O   1 
ATOM   2070 C CB  . SER D 2 64 ? -12.478 34.975  -0.789  1.00 27.89 ? 613 SER D CB  1 
ATOM   2071 O OG  . SER D 2 64 ? -11.861 35.843  0.137   1.00 38.85 ? 613 SER D OG  1 
ATOM   2072 N N   . VAL D 2 65 ? -12.647 33.435  -3.500  1.00 27.00 ? 614 VAL D N   1 
ATOM   2073 C CA  . VAL D 2 65 ? -13.095 32.405  -4.417  1.00 21.40 ? 614 VAL D CA  1 
ATOM   2074 C C   . VAL D 2 65 ? -11.897 31.697  -5.011  1.00 26.57 ? 614 VAL D C   1 
ATOM   2075 O O   . VAL D 2 65 ? -11.925 30.482  -5.262  1.00 29.93 ? 614 VAL D O   1 
ATOM   2076 C CB  . VAL D 2 65 ? -14.010 33.040  -5.477  1.00 18.76 ? 614 VAL D CB  1 
ATOM   2077 C CG1 . VAL D 2 65 ? -14.156 32.151  -6.691  1.00 20.22 ? 614 VAL D CG1 1 
ATOM   2078 C CG2 . VAL D 2 65 ? -15.349 33.330  -4.856  1.00 17.52 ? 614 VAL D CG2 1 
ATOM   2079 N N   . ILE D 2 66 ? -10.788 32.409  -5.211  1.00 25.67 ? 615 ILE D N   1 
ATOM   2080 C CA  . ILE D 2 66 ? -9.565  31.749  -5.636  1.00 26.06 ? 615 ILE D CA  1 
ATOM   2081 C C   . ILE D 2 66 ? -9.080  30.798  -4.547  1.00 29.10 ? 615 ILE D C   1 
ATOM   2082 O O   . ILE D 2 66 ? -8.676  29.668  -4.813  1.00 31.05 ? 615 ILE D O   1 
ATOM   2083 C CB  . ILE D 2 66 ? -8.477  32.774  -6.006  1.00 28.94 ? 615 ILE D CB  1 
ATOM   2084 C CG1 . ILE D 2 66 ? -8.684  33.300  -7.429  1.00 32.60 ? 615 ILE D CG1 1 
ATOM   2085 C CG2 . ILE D 2 66 ? -7.090  32.168  -5.874  1.00 29.00 ? 615 ILE D CG2 1 
ATOM   2086 C CD1 . ILE D 2 66 ? -7.691  34.375  -7.841  1.00 27.92 ? 615 ILE D CD1 1 
ATOM   2087 N N   . ARG D 2 67 ? -9.132  31.266  -3.295  1.00 30.29 ? 616 ARG D N   1 
ATOM   2088 C CA  . ARG D 2 67 ? -8.604  30.470  -2.186  1.00 31.03 ? 616 ARG D CA  1 
ATOM   2089 C C   . ARG D 2 67 ? -9.387  29.178  -2.012  1.00 28.92 ? 616 ARG D C   1 
ATOM   2090 O O   . ARG D 2 67 ? -8.808  28.118  -1.764  1.00 30.25 ? 616 ARG D O   1 
ATOM   2091 C CB  . ARG D 2 67 ? -8.629  31.297  -0.897  1.00 36.32 ? 616 ARG D CB  1 
ATOM   2092 C CG  . ARG D 2 67 ? -7.258  31.743  -0.407  1.00 36.71 ? 616 ARG D CG  1 
ATOM   2093 C CD  . ARG D 2 67 ? -7.391  32.731  0.724   1.00 32.81 ? 616 ARG D CD  1 
ATOM   2094 N NE  . ARG D 2 67 ? -6.675  33.960  0.419   1.00 39.86 ? 616 ARG D NE  1 
ATOM   2095 C CZ  . ARG D 2 67 ? -7.251  35.159  0.407   1.00 40.93 ? 616 ARG D CZ  1 
ATOM   2096 N NH1 . ARG D 2 67 ? -8.553  35.283  0.672   1.00 38.81 ? 616 ARG D NH1 1 
ATOM   2097 N NH2 . ARG D 2 67 ? -6.531  36.230  0.111   1.00 41.93 ? 616 ARG D NH2 1 
ATOM   2098 N N   . THR D 2 68 ? -10.709 29.246  -2.160  1.00 31.58 ? 617 THR D N   1 
ATOM   2099 C CA  . THR D 2 68 ? -11.529 28.043  -2.139  1.00 29.40 ? 617 THR D CA  1 
ATOM   2100 C C   . THR D 2 68 ? -11.157 27.098  -3.265  1.00 27.86 ? 617 THR D C   1 
ATOM   2101 O O   . THR D 2 68 ? -11.079 25.884  -3.061  1.00 35.88 ? 617 THR D O   1 
ATOM   2102 C CB  . THR D 2 68 ? -13.001 28.417  -2.239  1.00 31.23 ? 617 THR D CB  1 
ATOM   2103 O OG1 . THR D 2 68 ? -13.389 29.089  -1.041  1.00 37.59 ? 617 THR D OG1 1 
ATOM   2104 C CG2 . THR D 2 68 ? -13.857 27.171  -2.410  1.00 33.86 ? 617 THR D CG2 1 
ATOM   2105 N N   . LEU D 2 69 ? -10.931 27.630  -4.460  1.00 27.87 ? 618 LEU D N   1 
ATOM   2106 C CA  . LEU D 2 69 ? -10.608 26.812  -5.617  1.00 30.12 ? 618 LEU D CA  1 
ATOM   2107 C C   . LEU D 2 69 ? -9.174  26.363  -5.646  1.00 31.69 ? 618 LEU D C   1 
ATOM   2108 O O   . LEU D 2 69 ? -8.695  25.993  -6.724  1.00 34.56 ? 618 LEU D O   1 
ATOM   2109 C CB  . LEU D 2 69 ? -10.935 27.552  -6.913  1.00 29.85 ? 618 LEU D CB  1 
ATOM   2110 C CG  . LEU D 2 69 ? -12.361 28.042  -7.067  1.00 31.29 ? 618 LEU D CG  1 
ATOM   2111 C CD1 . LEU D 2 69 ? -12.512 28.955  -8.289  1.00 27.38 ? 618 LEU D CD1 1 
ATOM   2112 C CD2 . LEU D 2 69 ? -13.283 26.821  -7.133  1.00 30.56 ? 618 LEU D CD2 1 
ATOM   2113 N N   . ASP D 2 70 ? -8.478  26.399  -4.517  1.00 31.87 ? 619 ASP D N   1 
ATOM   2114 C CA  . ASP D 2 70 ? -7.183  25.748  -4.398  1.00 33.75 ? 619 ASP D CA  1 
ATOM   2115 C C   . ASP D 2 70 ? -7.187  24.407  -5.129  1.00 35.95 ? 619 ASP D C   1 
ATOM   2116 O O   . ASP D 2 70 ? -8.048  23.564  -4.872  1.00 39.20 ? 619 ASP D O   1 
ATOM   2117 C CB  . ASP D 2 70 ? -6.825  25.544  -2.930  1.00 37.77 ? 619 ASP D CB  1 
ATOM   2118 C CG  . ASP D 2 70 ? -5.336  25.434  -2.704  1.00 39.93 ? 619 ASP D CG  1 
ATOM   2119 O OD1 . ASP D 2 70 ? -4.588  25.163  -3.678  1.00 38.11 ? 619 ASP D OD1 1 
ATOM   2120 O OD2 . ASP D 2 70 ? -4.922  25.599  -1.539  1.00 41.16 ? 619 ASP D OD2 1 
ATOM   2121 N N   . PRO D 2 71 ? -6.286  24.227  -6.082  1.00 34.70 ? 620 PRO D N   1 
ATOM   2122 C CA  . PRO D 2 71 ? -6.198  22.933  -6.773  1.00 37.09 ? 620 PRO D CA  1 
ATOM   2123 C C   . PRO D 2 71 ? -5.542  21.854  -5.925  1.00 44.34 ? 620 PRO D C   1 
ATOM   2124 O O   . PRO D 2 71 ? -5.877  20.668  -6.065  1.00 49.32 ? 620 PRO D O   1 
ATOM   2125 C CB  . PRO D 2 71 ? -5.345  23.259  -8.008  1.00 37.82 ? 620 PRO D CB  1 
ATOM   2126 C CG  . PRO D 2 71 ? -4.635  24.552  -7.680  1.00 29.24 ? 620 PRO D CG  1 
ATOM   2127 C CD  . PRO D 2 71 ? -5.524  25.286  -6.759  1.00 29.69 ? 620 PRO D CD  1 
ATOM   2128 N N   . LYS D 2 72 ? -4.608  22.241  -5.046  1.00 40.60 ? 621 LYS D N   1 
ATOM   2129 C CA  . LYS D 2 72 ? -3.923  21.242  -4.233  1.00 39.52 ? 621 LYS D CA  1 
ATOM   2130 C C   . LYS D 2 72 ? -4.906  20.533  -3.306  1.00 48.30 ? 621 LYS D C   1 
ATOM   2131 O O   . LYS D 2 72 ? -4.723  19.355  -2.984  1.00 50.83 ? 621 LYS D O   1 
ATOM   2132 C CB  . LYS D 2 72 ? -2.785  21.887  -3.435  1.00 41.19 ? 621 LYS D CB  1 
ATOM   2133 C CG  . LYS D 2 72 ? -1.769  22.654  -4.292  1.00 48.91 ? 621 LYS D CG  1 
ATOM   2134 C CD  . LYS D 2 72 ? -0.367  22.773  -3.651  1.00 52.94 ? 621 LYS D CD  1 
ATOM   2135 C CE  . LYS D 2 72 ? 0.536   23.744  -4.462  1.00 60.72 ? 621 LYS D CE  1 
ATOM   2136 N NZ  . LYS D 2 72 ? 1.985   23.864  -4.047  1.00 53.90 ? 621 LYS D NZ  1 
ATOM   2137 N N   . GLN D 2 73 ? -5.963  21.224  -2.881  1.00 54.63 ? 622 GLN D N   1 
ATOM   2138 C CA  . GLN D 2 73 ? -6.974  20.614  -2.012  1.00 58.75 ? 622 GLN D CA  1 
ATOM   2139 C C   . GLN D 2 73 ? -7.872  19.649  -2.788  1.00 58.32 ? 622 GLN D C   1 
ATOM   2140 O O   . GLN D 2 73 ? -7.405  18.720  -3.442  1.00 60.41 ? 622 GLN D O   1 
ATOM   2141 C CB  . GLN D 2 73 ? -7.857  21.677  -1.349  1.00 60.00 ? 622 GLN D CB  1 
ATOM   2142 C CG  . GLN D 2 73 ? -7.148  22.812  -0.616  1.00 56.05 ? 622 GLN D CG  1 
ATOM   2143 C CD  . GLN D 2 73 ? -8.146  23.874  -0.134  1.00 60.85 ? 622 GLN D CD  1 
ATOM   2144 O OE1 . GLN D 2 73 ? -9.369  23.657  -0.193  1.00 59.92 ? 622 GLN D OE1 1 
ATOM   2145 N NE2 . GLN D 2 73 ? -7.634  25.033  0.313   1.00 49.30 ? 622 GLN D NE2 1 
HETATM 2146 O O   . HOH E 3 .  ? -1.527  28.182  -24.244 1.00 35.31 ? 901 HOH A O   1 
HETATM 2147 O O   . HOH E 3 .  ? -4.161  14.205  -9.182  1.00 44.03 ? 902 HOH A O   1 
HETATM 2148 O O   . HOH E 3 .  ? -4.887  17.635  -13.195 1.00 32.51 ? 903 HOH A O   1 
HETATM 2149 O O   . HOH E 3 .  ? -5.593  39.288  -6.477  1.00 26.96 ? 904 HOH A O   1 
HETATM 2150 O O   . HOH E 3 .  ? -4.615  41.616  -7.657  1.00 25.38 ? 905 HOH A O   1 
HETATM 2151 O O   . HOH E 3 .  ? -4.887  16.352  -7.204  1.00 31.12 ? 906 HOH A O   1 
HETATM 2152 O O   . HOH F 3 .  ? -21.232 22.968  3.273   1.00 31.77 ? 901 HOH B O   1 
HETATM 2153 O O   . HOH F 3 .  ? -22.309 27.012  8.046   1.00 45.89 ? 902 HOH B O   1 
HETATM 2154 O O   . HOH F 3 .  ? -23.873 28.698  -15.129 1.00 25.38 ? 903 HOH B O   1 
HETATM 2155 O O   . HOH F 3 .  ? -19.472 33.660  -18.053 1.00 40.21 ? 904 HOH B O   1 
HETATM 2156 O O   . HOH G 3 .  ? -16.331 123.818 -4.273  1.00 57.34 ? 701 HOH C O   1 
HETATM 2157 O O   . HOH G 3 .  ? -0.623  42.649  -18.102 1.00 43.45 ? 702 HOH C O   1 
HETATM 2158 O O   . HOH G 3 .  ? -9.235  103.892 -4.890  1.00 36.91 ? 703 HOH C O   1 
HETATM 2159 O O   . HOH G 3 .  ? -22.464 116.332 -8.334  1.00 37.97 ? 704 HOH C O   1 
HETATM 2160 O O   . HOH G 3 .  ? -16.341 34.359  -18.105 1.00 38.67 ? 705 HOH C O   1 
HETATM 2161 O O   . HOH G 3 .  ? 2.930   44.085  -13.556 1.00 25.38 ? 706 HOH C O   1 
HETATM 2162 O O   . HOH G 3 .  ? -29.927 119.192 -6.864  1.00 25.38 ? 707 HOH C O   1 
HETATM 2163 O O   . HOH G 3 .  ? -22.798 23.912  -13.846 1.00 32.76 ? 708 HOH C O   1 
HETATM 2164 O O   . HOH G 3 .  ? -14.865 16.806  -9.962  1.00 28.57 ? 709 HOH C O   1 
HETATM 2165 O O   . HOH G 3 .  ? -14.008 45.025  -17.135 1.00 25.38 ? 710 HOH C O   1 
HETATM 2166 O O   . HOH G 3 .  ? -4.107  53.410  -9.570  1.00 37.05 ? 711 HOH C O   1 
HETATM 2167 O O   . HOH H 3 .  ? -10.710 109.361 -12.822 1.00 45.89 ? 701 HOH D O   1 
HETATM 2168 O O   . HOH H 3 .  ? -4.122  33.988  0.609   1.00 36.70 ? 702 HOH D O   1 
HETATM 2169 O O   . HOH H 3 .  ? -9.937  23.606  -8.470  1.00 29.32 ? 703 HOH D O   1 
HETATM 2170 O O   . HOH H 3 .  ? -17.321 49.919  -8.788  1.00 35.49 ? 704 HOH D O   1 
HETATM 2171 O O   . HOH H 3 .  ? -24.844 88.648  -11.094 1.00 27.39 ? 705 HOH D O   1 
HETATM 2172 O O   . HOH H 3 .  ? -21.851 101.089 -7.110  1.00 34.59 ? 706 HOH D O   1 
# 
