data_9KN7
# 
_entry.id   9KN7 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9KN7         pdb_00009kn7 10.2210/pdb9kn7/pdb 
WWPDB D_1300053906 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-03-05 ? 
2 'Structure model' 1 1 2025-04-30 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
_pdbx_audit_revision_category.ordinal             1 
_pdbx_audit_revision_category.revision_ordinal    2 
_pdbx_audit_revision_category.data_content_type   'Structure model' 
_pdbx_audit_revision_category.category            citation 
# 
_pdbx_audit_revision_item.ordinal             1 
_pdbx_audit_revision_item.revision_ordinal    2 
_pdbx_audit_revision_item.data_content_type   'Structure model' 
_pdbx_audit_revision_item.item                '_citation.journal_volume' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9KN7 
_pdbx_database_status.recvd_initial_deposition_date   2024-11-18 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              tueno@bio.titech.ac.jp 
_pdbx_contact_author.name_first         Takafumi 
_pdbx_contact_author.name_last          Ueno 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-9219-0726 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Suzuki, T.'    1 0009-0000-0827-4485 
'Hishikawa, Y.' 2 0000-0002-4545-9195 
'Maity, B.'     3 0000-0001-9347-881X 
'Abe, S.'       4 0000-0002-7308-9670 
'Ueno, T.'      5 0000-0001-9219-0726 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   DE 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Adv Sci' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2198-3844 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            12 
_citation.language                  ? 
_citation.page_first                e2417030 
_citation.page_last                 e2417030 
_citation.title                     
'Design of Aromatic Interaction Networks in a Protein Cage Modulated by Fluorescent Ligand Binding.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1002/advs.202417030 
_citation.pdbx_database_id_PubMed   39973762 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Hishikawa, Y.'  1  ?                   
primary 'Suzuki, T.'     2  ?                   
primary 'Maity, B.'      3  ?                   
primary 'Noya, H.'       4  ?                   
primary 'Yoshizawa, M.'  5  ?                   
primary 'Asanuma, A.'    6  ?                   
primary 'Katagiri, Y.'   7  ?                   
primary 'Abe, S.'        8  ?                   
primary 'Nagatoishi, S.' 9  ?                   
primary 'Tsumoto, K.'    10 ?                   
primary 'Ueno, T.'       11 0000-0001-9219-0726 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Ferritin light chain' 19918.693 1   ? E53F/E56F/E57F/R59L/E60F/E63F ? ? 
2 non-polymer syn 'CADMIUM ION'          112.411   8   ? ?                             ? ? 
3 non-polymer syn 'SULFATE ION'          96.063    2   ? ?                             ? ? 
4 non-polymer syn 'CHLORIDE ION'         35.453    1   ? ?                             ? ? 
5 non-polymer syn 1,2-ETHANEDIOL         62.068    4   ? ?                             ? ? 
6 water       nat water                  18.015    226 ? ?                             ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Ferritin L subunit' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SSQIRQNYSTEVEAAVNRLVNLYLRASYTYLSLGFYFDRDDVALEGVCHFFRFLAFFKLFGAFRLLKMQNQRGGRALFQD
LQKPSQDEWGTTLDAMKAAIVLEKSLNQALLDLHALGSAQADPHLCDFLESHFLDEEVKLIKKMGDHLTNIQRLVGSQAG
LGEYLFERLTLKHD
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SSQIRQNYSTEVEAAVNRLVNLYLRASYTYLSLGFYFDRDDVALEGVCHFFRFLAFFKLFGAFRLLKMQNQRGGRALFQD
LQKPSQDEWGTTLDAMKAAIVLEKSLNQALLDLHALGSAQADPHLCDFLESHFLDEEVKLIKKMGDHLTNIQRLVGSQAG
LGEYLFERLTLKHD
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'CADMIUM ION'  CD  
3 'SULFATE ION'  SO4 
4 'CHLORIDE ION' CL  
5 1,2-ETHANEDIOL EDO 
6 water          HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   SER n 
1 3   GLN n 
1 4   ILE n 
1 5   ARG n 
1 6   GLN n 
1 7   ASN n 
1 8   TYR n 
1 9   SER n 
1 10  THR n 
1 11  GLU n 
1 12  VAL n 
1 13  GLU n 
1 14  ALA n 
1 15  ALA n 
1 16  VAL n 
1 17  ASN n 
1 18  ARG n 
1 19  LEU n 
1 20  VAL n 
1 21  ASN n 
1 22  LEU n 
1 23  TYR n 
1 24  LEU n 
1 25  ARG n 
1 26  ALA n 
1 27  SER n 
1 28  TYR n 
1 29  THR n 
1 30  TYR n 
1 31  LEU n 
1 32  SER n 
1 33  LEU n 
1 34  GLY n 
1 35  PHE n 
1 36  TYR n 
1 37  PHE n 
1 38  ASP n 
1 39  ARG n 
1 40  ASP n 
1 41  ASP n 
1 42  VAL n 
1 43  ALA n 
1 44  LEU n 
1 45  GLU n 
1 46  GLY n 
1 47  VAL n 
1 48  CYS n 
1 49  HIS n 
1 50  PHE n 
1 51  PHE n 
1 52  ARG n 
1 53  PHE n 
1 54  LEU n 
1 55  ALA n 
1 56  PHE n 
1 57  PHE n 
1 58  LYS n 
1 59  LEU n 
1 60  PHE n 
1 61  GLY n 
1 62  ALA n 
1 63  PHE n 
1 64  ARG n 
1 65  LEU n 
1 66  LEU n 
1 67  LYS n 
1 68  MET n 
1 69  GLN n 
1 70  ASN n 
1 71  GLN n 
1 72  ARG n 
1 73  GLY n 
1 74  GLY n 
1 75  ARG n 
1 76  ALA n 
1 77  LEU n 
1 78  PHE n 
1 79  GLN n 
1 80  ASP n 
1 81  LEU n 
1 82  GLN n 
1 83  LYS n 
1 84  PRO n 
1 85  SER n 
1 86  GLN n 
1 87  ASP n 
1 88  GLU n 
1 89  TRP n 
1 90  GLY n 
1 91  THR n 
1 92  THR n 
1 93  LEU n 
1 94  ASP n 
1 95  ALA n 
1 96  MET n 
1 97  LYS n 
1 98  ALA n 
1 99  ALA n 
1 100 ILE n 
1 101 VAL n 
1 102 LEU n 
1 103 GLU n 
1 104 LYS n 
1 105 SER n 
1 106 LEU n 
1 107 ASN n 
1 108 GLN n 
1 109 ALA n 
1 110 LEU n 
1 111 LEU n 
1 112 ASP n 
1 113 LEU n 
1 114 HIS n 
1 115 ALA n 
1 116 LEU n 
1 117 GLY n 
1 118 SER n 
1 119 ALA n 
1 120 GLN n 
1 121 ALA n 
1 122 ASP n 
1 123 PRO n 
1 124 HIS n 
1 125 LEU n 
1 126 CYS n 
1 127 ASP n 
1 128 PHE n 
1 129 LEU n 
1 130 GLU n 
1 131 SER n 
1 132 HIS n 
1 133 PHE n 
1 134 LEU n 
1 135 ASP n 
1 136 GLU n 
1 137 GLU n 
1 138 VAL n 
1 139 LYS n 
1 140 LEU n 
1 141 ILE n 
1 142 LYS n 
1 143 LYS n 
1 144 MET n 
1 145 GLY n 
1 146 ASP n 
1 147 HIS n 
1 148 LEU n 
1 149 THR n 
1 150 ASN n 
1 151 ILE n 
1 152 GLN n 
1 153 ARG n 
1 154 LEU n 
1 155 VAL n 
1 156 GLY n 
1 157 SER n 
1 158 GLN n 
1 159 ALA n 
1 160 GLY n 
1 161 LEU n 
1 162 GLY n 
1 163 GLU n 
1 164 TYR n 
1 165 LEU n 
1 166 PHE n 
1 167 GLU n 
1 168 ARG n 
1 169 LEU n 
1 170 THR n 
1 171 LEU n 
1 172 LYS n 
1 173 HIS n 
1 174 ASP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   174 
_entity_src_gen.gene_src_common_name               horse 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 FTL 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Equus caballus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9796 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ?                 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ?                 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ?                 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                 'C4 H7 N O4'     133.103 
CD  non-polymer         . 'CADMIUM ION'   ?                 'Cd 2'           112.411 
CL  non-polymer         . 'CHLORIDE ION'  ?                 'Cl -1'          35.453  
CYS 'L-peptide linking' y CYSTEINE        ?                 'C3 H7 N O2 S'   121.158 
EDO non-polymer         . 1,2-ETHANEDIOL  'ETHYLENE GLYCOL' 'C2 H6 O2'       62.068  
GLN 'L-peptide linking' y GLUTAMINE       ?                 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ?                 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ?                 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ?                 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ?                 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ?                 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ?                 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ?                 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ?                 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ?                 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ?                 'C3 H7 N O3'     105.093 
SO4 non-polymer         . 'SULFATE ION'   ?                 'O4 S -2'        96.063  
THR 'L-peptide linking' y THREONINE       ?                 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ?                 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ?                 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ?                 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   SER 2   2   2   SER SER A . n 
A 1 3   GLN 3   3   3   GLN GLN A . n 
A 1 4   ILE 4   4   4   ILE ILE A . n 
A 1 5   ARG 5   5   5   ARG ARG A . n 
A 1 6   GLN 6   6   6   GLN GLN A . n 
A 1 7   ASN 7   7   7   ASN ASN A . n 
A 1 8   TYR 8   8   8   TYR TYR A . n 
A 1 9   SER 9   9   9   SER SER A . n 
A 1 10  THR 10  10  10  THR THR A . n 
A 1 11  GLU 11  11  11  GLU GLU A . n 
A 1 12  VAL 12  12  12  VAL VAL A . n 
A 1 13  GLU 13  13  13  GLU GLU A . n 
A 1 14  ALA 14  14  14  ALA ALA A . n 
A 1 15  ALA 15  15  15  ALA ALA A . n 
A 1 16  VAL 16  16  16  VAL VAL A . n 
A 1 17  ASN 17  17  17  ASN ASN A . n 
A 1 18  ARG 18  18  18  ARG ARG A . n 
A 1 19  LEU 19  19  19  LEU LEU A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  ASN 21  21  21  ASN ASN A . n 
A 1 22  LEU 22  22  22  LEU LEU A . n 
A 1 23  TYR 23  23  23  TYR TYR A . n 
A 1 24  LEU 24  24  24  LEU LEU A . n 
A 1 25  ARG 25  25  25  ARG ARG A . n 
A 1 26  ALA 26  26  26  ALA ALA A . n 
A 1 27  SER 27  27  27  SER SER A . n 
A 1 28  TYR 28  28  28  TYR TYR A . n 
A 1 29  THR 29  29  29  THR THR A . n 
A 1 30  TYR 30  30  30  TYR TYR A . n 
A 1 31  LEU 31  31  31  LEU LEU A . n 
A 1 32  SER 32  32  32  SER SER A . n 
A 1 33  LEU 33  33  33  LEU LEU A . n 
A 1 34  GLY 34  34  34  GLY GLY A . n 
A 1 35  PHE 35  35  35  PHE PHE A . n 
A 1 36  TYR 36  36  36  TYR TYR A . n 
A 1 37  PHE 37  37  37  PHE PHE A . n 
A 1 38  ASP 38  38  38  ASP ASP A . n 
A 1 39  ARG 39  39  39  ARG ARG A . n 
A 1 40  ASP 40  40  40  ASP ASP A . n 
A 1 41  ASP 41  41  41  ASP ASP A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ALA 43  43  43  ALA ALA A . n 
A 1 44  LEU 44  44  44  LEU LEU A . n 
A 1 45  GLU 45  45  45  GLU GLU A . n 
A 1 46  GLY 46  46  46  GLY GLY A . n 
A 1 47  VAL 47  47  47  VAL VAL A . n 
A 1 48  CYS 48  48  48  CYS CYS A . n 
A 1 49  HIS 49  49  49  HIS HIS A . n 
A 1 50  PHE 50  50  50  PHE PHE A . n 
A 1 51  PHE 51  51  51  PHE PHE A . n 
A 1 52  ARG 52  52  52  ARG ARG A . n 
A 1 53  PHE 53  53  53  PHE PHE A . n 
A 1 54  LEU 54  54  54  LEU LEU A . n 
A 1 55  ALA 55  55  55  ALA ALA A . n 
A 1 56  PHE 56  56  56  PHE PHE A . n 
A 1 57  PHE 57  57  57  PHE PHE A . n 
A 1 58  LYS 58  58  58  LYS LYS A . n 
A 1 59  LEU 59  59  59  LEU LEU A . n 
A 1 60  PHE 60  60  60  PHE PHE A . n 
A 1 61  GLY 61  61  61  GLY GLY A . n 
A 1 62  ALA 62  62  62  ALA ALA A . n 
A 1 63  PHE 63  63  63  PHE PHE A . n 
A 1 64  ARG 64  64  64  ARG ARG A . n 
A 1 65  LEU 65  65  65  LEU LEU A . n 
A 1 66  LEU 66  66  66  LEU LEU A . n 
A 1 67  LYS 67  67  67  LYS LYS A . n 
A 1 68  MET 68  68  68  MET MET A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ASN 70  70  70  ASN ASN A . n 
A 1 71  GLN 71  71  71  GLN GLN A . n 
A 1 72  ARG 72  72  72  ARG ARG A . n 
A 1 73  GLY 73  73  73  GLY GLY A . n 
A 1 74  GLY 74  74  74  GLY GLY A . n 
A 1 75  ARG 75  75  75  ARG ARG A . n 
A 1 76  ALA 76  76  76  ALA ALA A . n 
A 1 77  LEU 77  77  77  LEU LEU A . n 
A 1 78  PHE 78  78  78  PHE PHE A . n 
A 1 79  GLN 79  79  79  GLN GLN A . n 
A 1 80  ASP 80  80  80  ASP ASP A . n 
A 1 81  LEU 81  81  81  LEU LEU A . n 
A 1 82  GLN 82  82  82  GLN GLN A . n 
A 1 83  LYS 83  83  83  LYS LYS A . n 
A 1 84  PRO 84  84  84  PRO PRO A . n 
A 1 85  SER 85  85  85  SER SER A . n 
A 1 86  GLN 86  86  86  GLN GLN A . n 
A 1 87  ASP 87  87  87  ASP ASP A . n 
A 1 88  GLU 88  88  88  GLU GLU A . n 
A 1 89  TRP 89  89  89  TRP TRP A . n 
A 1 90  GLY 90  90  90  GLY GLY A . n 
A 1 91  THR 91  91  91  THR THR A . n 
A 1 92  THR 92  92  92  THR THR A . n 
A 1 93  LEU 93  93  93  LEU LEU A . n 
A 1 94  ASP 94  94  94  ASP ASP A . n 
A 1 95  ALA 95  95  95  ALA ALA A . n 
A 1 96  MET 96  96  96  MET MET A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  ALA 98  98  98  ALA ALA A . n 
A 1 99  ALA 99  99  99  ALA ALA A . n 
A 1 100 ILE 100 100 100 ILE ILE A . n 
A 1 101 VAL 101 101 101 VAL VAL A . n 
A 1 102 LEU 102 102 102 LEU LEU A . n 
A 1 103 GLU 103 103 103 GLU GLU A . n 
A 1 104 LYS 104 104 104 LYS LYS A . n 
A 1 105 SER 105 105 105 SER SER A . n 
A 1 106 LEU 106 106 106 LEU LEU A . n 
A 1 107 ASN 107 107 107 ASN ASN A . n 
A 1 108 GLN 108 108 108 GLN GLN A . n 
A 1 109 ALA 109 109 109 ALA ALA A . n 
A 1 110 LEU 110 110 110 LEU LEU A . n 
A 1 111 LEU 111 111 111 LEU LEU A . n 
A 1 112 ASP 112 112 112 ASP ASP A . n 
A 1 113 LEU 113 113 113 LEU LEU A . n 
A 1 114 HIS 114 114 114 HIS HIS A . n 
A 1 115 ALA 115 115 115 ALA ALA A . n 
A 1 116 LEU 116 116 116 LEU LEU A . n 
A 1 117 GLY 117 117 117 GLY GLY A . n 
A 1 118 SER 118 118 118 SER SER A . n 
A 1 119 ALA 119 119 119 ALA ALA A . n 
A 1 120 GLN 120 120 120 GLN GLN A . n 
A 1 121 ALA 121 121 121 ALA ALA A . n 
A 1 122 ASP 122 122 122 ASP ASP A . n 
A 1 123 PRO 123 123 123 PRO PRO A . n 
A 1 124 HIS 124 124 124 HIS HIS A . n 
A 1 125 LEU 125 125 125 LEU LEU A . n 
A 1 126 CYS 126 126 126 CYS CYS A . n 
A 1 127 ASP 127 127 127 ASP ASP A . n 
A 1 128 PHE 128 128 128 PHE PHE A . n 
A 1 129 LEU 129 129 129 LEU LEU A . n 
A 1 130 GLU 130 130 130 GLU GLU A . n 
A 1 131 SER 131 131 131 SER SER A . n 
A 1 132 HIS 132 132 132 HIS HIS A . n 
A 1 133 PHE 133 133 133 PHE PHE A . n 
A 1 134 LEU 134 134 134 LEU LEU A . n 
A 1 135 ASP 135 135 135 ASP ASP A . n 
A 1 136 GLU 136 136 136 GLU GLU A . n 
A 1 137 GLU 137 137 137 GLU GLU A . n 
A 1 138 VAL 138 138 138 VAL VAL A . n 
A 1 139 LYS 139 139 139 LYS LYS A . n 
A 1 140 LEU 140 140 140 LEU LEU A . n 
A 1 141 ILE 141 141 141 ILE ILE A . n 
A 1 142 LYS 142 142 142 LYS LYS A . n 
A 1 143 LYS 143 143 143 LYS LYS A . n 
A 1 144 MET 144 144 144 MET MET A . n 
A 1 145 GLY 145 145 145 GLY GLY A . n 
A 1 146 ASP 146 146 146 ASP ASP A . n 
A 1 147 HIS 147 147 147 HIS HIS A . n 
A 1 148 LEU 148 148 148 LEU LEU A . n 
A 1 149 THR 149 149 149 THR THR A . n 
A 1 150 ASN 150 150 150 ASN ASN A . n 
A 1 151 ILE 151 151 151 ILE ILE A . n 
A 1 152 GLN 152 152 152 GLN GLN A . n 
A 1 153 ARG 153 153 153 ARG ARG A . n 
A 1 154 LEU 154 154 154 LEU LEU A . n 
A 1 155 VAL 155 155 155 VAL VAL A . n 
A 1 156 GLY 156 156 156 GLY GLY A . n 
A 1 157 SER 157 157 157 SER SER A . n 
A 1 158 GLN 158 158 158 GLN GLN A . n 
A 1 159 ALA 159 159 159 ALA ALA A . n 
A 1 160 GLY 160 160 160 GLY GLY A . n 
A 1 161 LEU 161 161 161 LEU LEU A . n 
A 1 162 GLY 162 162 162 GLY GLY A . n 
A 1 163 GLU 163 163 163 GLU GLU A . n 
A 1 164 TYR 164 164 164 TYR TYR A . n 
A 1 165 LEU 165 165 165 LEU LEU A . n 
A 1 166 PHE 166 166 166 PHE PHE A . n 
A 1 167 GLU 167 167 167 GLU GLU A . n 
A 1 168 ARG 168 168 168 ARG ARG A . n 
A 1 169 LEU 169 169 169 LEU LEU A . n 
A 1 170 THR 170 170 170 THR THR A . n 
A 1 171 LEU 171 171 171 LEU LEU A . n 
A 1 172 LYS 172 172 172 LYS LYS A . n 
A 1 173 HIS 173 173 173 HIS HIS A . n 
A 1 174 ASP 174 174 174 ASP ASP A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 CD  1   201 1   CD  CD  A . 
C 2 CD  1   202 2   CD  CD  A . 
D 2 CD  1   203 3   CD  CD  A . 
E 2 CD  1   204 4   CD  CD  A . 
F 2 CD  1   205 5   CD  CD  A . 
G 2 CD  1   206 6   CD  CD  A . 
H 2 CD  1   207 7   CD  CD  A . 
I 2 CD  1   208 8   CD  CD  A . 
J 3 SO4 1   209 1   SO4 SO4 A . 
K 3 SO4 1   210 2   SO4 SO4 A . 
L 4 CL  1   211 1   CL  CL  A . 
M 5 EDO 1   212 201 EDO EDO A . 
N 5 EDO 1   213 301 EDO EDO A . 
O 5 EDO 1   214 501 EDO EDO A . 
P 5 EDO 1   215 601 EDO EDO A . 
Q 6 HOH 1   301 266 HOH HOH A . 
Q 6 HOH 2   302 288 HOH HOH A . 
Q 6 HOH 3   303 286 HOH HOH A . 
Q 6 HOH 4   304 269 HOH HOH A . 
Q 6 HOH 5   305 95  HOH HOH A . 
Q 6 HOH 6   306 284 HOH HOH A . 
Q 6 HOH 7   307 32  HOH HOH A . 
Q 6 HOH 8   308 72  HOH HOH A . 
Q 6 HOH 9   309 272 HOH HOH A . 
Q 6 HOH 10  310 41  HOH HOH A . 
Q 6 HOH 11  311 282 HOH HOH A . 
Q 6 HOH 12  312 194 HOH HOH A . 
Q 6 HOH 13  313 260 HOH HOH A . 
Q 6 HOH 14  314 2   HOH HOH A . 
Q 6 HOH 15  315 100 HOH HOH A . 
Q 6 HOH 16  316 152 HOH HOH A . 
Q 6 HOH 17  317 267 HOH HOH A . 
Q 6 HOH 18  318 168 HOH HOH A . 
Q 6 HOH 19  319 157 HOH HOH A . 
Q 6 HOH 20  320 158 HOH HOH A . 
Q 6 HOH 21  321 90  HOH HOH A . 
Q 6 HOH 22  322 153 HOH HOH A . 
Q 6 HOH 23  323 273 HOH HOH A . 
Q 6 HOH 24  324 179 HOH HOH A . 
Q 6 HOH 25  325 280 HOH HOH A . 
Q 6 HOH 26  326 96  HOH HOH A . 
Q 6 HOH 27  327 176 HOH HOH A . 
Q 6 HOH 28  328 36  HOH HOH A . 
Q 6 HOH 29  329 40  HOH HOH A . 
Q 6 HOH 30  330 107 HOH HOH A . 
Q 6 HOH 31  331 276 HOH HOH A . 
Q 6 HOH 32  332 229 HOH HOH A . 
Q 6 HOH 33  333 12  HOH HOH A . 
Q 6 HOH 34  334 227 HOH HOH A . 
Q 6 HOH 35  335 94  HOH HOH A . 
Q 6 HOH 36  336 78  HOH HOH A . 
Q 6 HOH 37  337 21  HOH HOH A . 
Q 6 HOH 38  338 10  HOH HOH A . 
Q 6 HOH 39  339 156 HOH HOH A . 
Q 6 HOH 40  340 287 HOH HOH A . 
Q 6 HOH 41  341 11  HOH HOH A . 
Q 6 HOH 42  342 253 HOH HOH A . 
Q 6 HOH 43  343 93  HOH HOH A . 
Q 6 HOH 44  344 14  HOH HOH A . 
Q 6 HOH 45  345 265 HOH HOH A . 
Q 6 HOH 46  346 84  HOH HOH A . 
Q 6 HOH 47  347 99  HOH HOH A . 
Q 6 HOH 48  348 224 HOH HOH A . 
Q 6 HOH 49  349 29  HOH HOH A . 
Q 6 HOH 50  350 27  HOH HOH A . 
Q 6 HOH 51  351 23  HOH HOH A . 
Q 6 HOH 52  352 50  HOH HOH A . 
Q 6 HOH 53  353 5   HOH HOH A . 
Q 6 HOH 54  354 53  HOH HOH A . 
Q 6 HOH 55  355 59  HOH HOH A . 
Q 6 HOH 56  356 279 HOH HOH A . 
Q 6 HOH 57  357 55  HOH HOH A . 
Q 6 HOH 58  358 15  HOH HOH A . 
Q 6 HOH 59  359 270 HOH HOH A . 
Q 6 HOH 60  360 60  HOH HOH A . 
Q 6 HOH 61  361 18  HOH HOH A . 
Q 6 HOH 62  362 117 HOH HOH A . 
Q 6 HOH 63  363 151 HOH HOH A . 
Q 6 HOH 64  364 45  HOH HOH A . 
Q 6 HOH 65  365 132 HOH HOH A . 
Q 6 HOH 66  366 83  HOH HOH A . 
Q 6 HOH 67  367 86  HOH HOH A . 
Q 6 HOH 68  368 8   HOH HOH A . 
Q 6 HOH 69  369 34  HOH HOH A . 
Q 6 HOH 70  370 17  HOH HOH A . 
Q 6 HOH 71  371 6   HOH HOH A . 
Q 6 HOH 72  372 58  HOH HOH A . 
Q 6 HOH 73  373 35  HOH HOH A . 
Q 6 HOH 74  374 145 HOH HOH A . 
Q 6 HOH 75  375 49  HOH HOH A . 
Q 6 HOH 76  376 47  HOH HOH A . 
Q 6 HOH 77  377 149 HOH HOH A . 
Q 6 HOH 78  378 25  HOH HOH A . 
Q 6 HOH 79  379 62  HOH HOH A . 
Q 6 HOH 80  380 175 HOH HOH A . 
Q 6 HOH 81  381 119 HOH HOH A . 
Q 6 HOH 82  382 103 HOH HOH A . 
Q 6 HOH 83  383 141 HOH HOH A . 
Q 6 HOH 84  384 256 HOH HOH A . 
Q 6 HOH 85  385 159 HOH HOH A . 
Q 6 HOH 86  386 46  HOH HOH A . 
Q 6 HOH 87  387 42  HOH HOH A . 
Q 6 HOH 88  388 199 HOH HOH A . 
Q 6 HOH 89  389 122 HOH HOH A . 
Q 6 HOH 90  390 164 HOH HOH A . 
Q 6 HOH 91  391 30  HOH HOH A . 
Q 6 HOH 92  392 33  HOH HOH A . 
Q 6 HOH 93  393 104 HOH HOH A . 
Q 6 HOH 94  394 43  HOH HOH A . 
Q 6 HOH 95  395 4   HOH HOH A . 
Q 6 HOH 96  396 123 HOH HOH A . 
Q 6 HOH 97  397 87  HOH HOH A . 
Q 6 HOH 98  398 183 HOH HOH A . 
Q 6 HOH 99  399 44  HOH HOH A . 
Q 6 HOH 100 400 54  HOH HOH A . 
Q 6 HOH 101 401 202 HOH HOH A . 
Q 6 HOH 102 402 69  HOH HOH A . 
Q 6 HOH 103 403 188 HOH HOH A . 
Q 6 HOH 104 404 24  HOH HOH A . 
Q 6 HOH 105 405 7   HOH HOH A . 
Q 6 HOH 106 406 129 HOH HOH A . 
Q 6 HOH 107 407 38  HOH HOH A . 
Q 6 HOH 108 408 63  HOH HOH A . 
Q 6 HOH 109 409 37  HOH HOH A . 
Q 6 HOH 110 410 271 HOH HOH A . 
Q 6 HOH 111 411 52  HOH HOH A . 
Q 6 HOH 112 412 124 HOH HOH A . 
Q 6 HOH 113 413 140 HOH HOH A . 
Q 6 HOH 114 414 110 HOH HOH A . 
Q 6 HOH 115 415 160 HOH HOH A . 
Q 6 HOH 116 416 173 HOH HOH A . 
Q 6 HOH 117 417 67  HOH HOH A . 
Q 6 HOH 118 418 126 HOH HOH A . 
Q 6 HOH 119 419 9   HOH HOH A . 
Q 6 HOH 120 420 277 HOH HOH A . 
Q 6 HOH 121 421 143 HOH HOH A . 
Q 6 HOH 122 422 139 HOH HOH A . 
Q 6 HOH 123 423 73  HOH HOH A . 
Q 6 HOH 124 424 131 HOH HOH A . 
Q 6 HOH 125 425 257 HOH HOH A . 
Q 6 HOH 126 426 88  HOH HOH A . 
Q 6 HOH 127 427 51  HOH HOH A . 
Q 6 HOH 128 428 22  HOH HOH A . 
Q 6 HOH 129 429 28  HOH HOH A . 
Q 6 HOH 130 430 97  HOH HOH A . 
Q 6 HOH 131 431 75  HOH HOH A . 
Q 6 HOH 132 432 190 HOH HOH A . 
Q 6 HOH 133 433 48  HOH HOH A . 
Q 6 HOH 134 434 186 HOH HOH A . 
Q 6 HOH 135 435 275 HOH HOH A . 
Q 6 HOH 136 436 163 HOH HOH A . 
Q 6 HOH 137 437 278 HOH HOH A . 
Q 6 HOH 138 438 68  HOH HOH A . 
Q 6 HOH 139 439 56  HOH HOH A . 
Q 6 HOH 140 440 191 HOH HOH A . 
Q 6 HOH 141 441 71  HOH HOH A . 
Q 6 HOH 142 442 127 HOH HOH A . 
Q 6 HOH 143 443 57  HOH HOH A . 
Q 6 HOH 144 444 169 HOH HOH A . 
Q 6 HOH 145 445 16  HOH HOH A . 
Q 6 HOH 146 446 111 HOH HOH A . 
Q 6 HOH 147 447 76  HOH HOH A . 
Q 6 HOH 148 448 39  HOH HOH A . 
Q 6 HOH 149 449 209 HOH HOH A . 
Q 6 HOH 150 450 81  HOH HOH A . 
Q 6 HOH 151 451 125 HOH HOH A . 
Q 6 HOH 152 452 255 HOH HOH A . 
Q 6 HOH 153 453 268 HOH HOH A . 
Q 6 HOH 154 454 247 HOH HOH A . 
Q 6 HOH 155 455 77  HOH HOH A . 
Q 6 HOH 156 456 31  HOH HOH A . 
Q 6 HOH 157 457 128 HOH HOH A . 
Q 6 HOH 158 458 150 HOH HOH A . 
Q 6 HOH 159 459 113 HOH HOH A . 
Q 6 HOH 160 460 285 HOH HOH A . 
Q 6 HOH 161 461 101 HOH HOH A . 
Q 6 HOH 162 462 108 HOH HOH A . 
Q 6 HOH 163 463 92  HOH HOH A . 
Q 6 HOH 164 464 106 HOH HOH A . 
Q 6 HOH 165 465 226 HOH HOH A . 
Q 6 HOH 166 466 70  HOH HOH A . 
Q 6 HOH 167 467 61  HOH HOH A . 
Q 6 HOH 168 468 248 HOH HOH A . 
Q 6 HOH 169 469 137 HOH HOH A . 
Q 6 HOH 170 470 13  HOH HOH A . 
Q 6 HOH 171 471 239 HOH HOH A . 
Q 6 HOH 172 472 64  HOH HOH A . 
Q 6 HOH 173 473 251 HOH HOH A . 
Q 6 HOH 174 474 144 HOH HOH A . 
Q 6 HOH 175 475 80  HOH HOH A . 
Q 6 HOH 176 476 136 HOH HOH A . 
Q 6 HOH 177 477 213 HOH HOH A . 
Q 6 HOH 178 478 65  HOH HOH A . 
Q 6 HOH 179 479 130 HOH HOH A . 
Q 6 HOH 180 480 198 HOH HOH A . 
Q 6 HOH 181 481 234 HOH HOH A . 
Q 6 HOH 182 482 259 HOH HOH A . 
Q 6 HOH 183 483 205 HOH HOH A . 
Q 6 HOH 184 484 223 HOH HOH A . 
Q 6 HOH 185 485 218 HOH HOH A . 
Q 6 HOH 186 486 281 HOH HOH A . 
Q 6 HOH 187 487 242 HOH HOH A . 
Q 6 HOH 188 488 225 HOH HOH A . 
Q 6 HOH 189 489 214 HOH HOH A . 
Q 6 HOH 190 490 142 HOH HOH A . 
Q 6 HOH 191 491 261 HOH HOH A . 
Q 6 HOH 192 492 283 HOH HOH A . 
Q 6 HOH 193 493 118 HOH HOH A . 
Q 6 HOH 194 494 133 HOH HOH A . 
Q 6 HOH 195 495 161 HOH HOH A . 
Q 6 HOH 196 496 181 HOH HOH A . 
Q 6 HOH 197 497 254 HOH HOH A . 
Q 6 HOH 198 498 252 HOH HOH A . 
Q 6 HOH 199 499 232 HOH HOH A . 
Q 6 HOH 200 500 220 HOH HOH A . 
Q 6 HOH 201 501 178 HOH HOH A . 
Q 6 HOH 202 502 240 HOH HOH A . 
Q 6 HOH 203 503 91  HOH HOH A . 
Q 6 HOH 204 504 262 HOH HOH A . 
Q 6 HOH 205 505 138 HOH HOH A . 
Q 6 HOH 206 506 245 HOH HOH A . 
Q 6 HOH 207 507 135 HOH HOH A . 
Q 6 HOH 208 508 120 HOH HOH A . 
Q 6 HOH 209 509 146 HOH HOH A . 
Q 6 HOH 210 510 109 HOH HOH A . 
Q 6 HOH 211 511 112 HOH HOH A . 
Q 6 HOH 212 512 116 HOH HOH A . 
Q 6 HOH 213 513 74  HOH HOH A . 
Q 6 HOH 214 514 85  HOH HOH A . 
Q 6 HOH 215 515 244 HOH HOH A . 
Q 6 HOH 216 516 246 HOH HOH A . 
Q 6 HOH 217 517 115 HOH HOH A . 
Q 6 HOH 218 518 222 HOH HOH A . 
Q 6 HOH 219 519 235 HOH HOH A . 
Q 6 HOH 220 520 241 HOH HOH A . 
Q 6 HOH 221 521 274 HOH HOH A . 
Q 6 HOH 222 522 114 HOH HOH A . 
Q 6 HOH 223 523 236 HOH HOH A . 
Q 6 HOH 224 524 233 HOH HOH A . 
Q 6 HOH 225 525 217 HOH HOH A . 
Q 6 HOH 226 526 237 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A SER 1   ? CB  ? A SER 1   CB  
2  1 Y 1 A SER 1   ? OG  ? A SER 1   OG  
3  1 Y 1 A SER 157 ? CB  ? A SER 157 CB  
4  1 Y 1 A SER 157 ? OG  ? A SER 157 OG  
5  1 Y 1 A GLN 158 ? OE1 ? A GLN 158 OE1 
6  1 Y 1 A GLN 158 ? NE2 ? A GLN 158 NE2 
7  1 Y 1 A LYS 172 ? CG  ? A LYS 172 CG  
8  1 Y 1 A LYS 172 ? CD  ? A LYS 172 CD  
9  1 Y 1 A LYS 172 ? CE  ? A LYS 172 CE  
10 1 Y 1 A LYS 172 ? NZ  ? A LYS 172 NZ  
11 1 Y 1 A ASP 174 ? CB  ? A ASP 174 CB  
12 1 Y 1 A ASP 174 ? CG  ? A ASP 174 CG  
13 1 Y 1 A ASP 174 ? OD1 ? A ASP 174 OD1 
14 1 Y 1 A ASP 174 ? OD2 ? A ASP 174 OD2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? 'data collection' ? ? ? ? ? ? ? ? ? ? ? CrysalisPro ? ? ? . 1 
? 'data reduction'  ? ? ? ? ? ? ? ? ? ? ? CrysalisPro ? ? ? . 2 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? Aimless     ? ? ? . 3 
? phasing           ? ? ? ? ? ? ? ? ? ? ? MOLREP      ? ? ? . 4 
? refinement        ? ? ? ? ? ? ? ? ? ? ? REFMAC      ? ? ? 5 5 
? 'model building'  ? ? ? ? ? ? ? ? ? ? ? Coot        ? ? ? . 6 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9KN7 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     180.715 
_cell.length_a_esd                 ? 
_cell.length_b                     180.715 
_cell.length_b_esd                 ? 
_cell.length_c                     180.715 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        96 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9KN7 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                209 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'F 4 3 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9KN7 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.09 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          60.15 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              8.0 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    Incubation 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'Ammonium sulfate, Cadmium sulfate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     93 
_diffrn.ambient_temp_details             'Liquid N2 vapour' 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'RIGAKU HyPix-6000HE' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-06-16 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.54184 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        'RIGAKU FR-E DW' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.54184 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9KN7 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.50 
_reflns.d_resolution_low                               18.94 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     40895 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                9.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          31.8 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               0.98 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.051 
_reflns.pdbx_Rpim_I_all                                0.015 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   1.000 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.049 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.50 
_reflns_shell.d_res_low                                     1.53 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           4.5 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1981 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               6.7 
_reflns_shell.pdbx_chi_squared                              0.98 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               0.429 
_reflns_shell.pdbx_Rpim_I_all                               0.165 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.941 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          100.0 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.396 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9KN7 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.50 
_refine.ls_d_res_low                             18.94 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     40810 
_refine.ls_number_reflns_R_free                  2068 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.79 
_refine.ls_percent_reflns_R_free                 5.07 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1653 
_refine.ls_R_factor_R_free                       0.1782 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1646 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      1DAT 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 18.06 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.13 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        1390 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         35 
_refine_hist.number_atoms_solvent             226 
_refine_hist.number_atoms_total               1651 
_refine_hist.d_res_high                       1.50 
_refine_hist.d_res_low                        18.94 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.013  ? 1508 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.741  ? 2039 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 13.742 ? 565  ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.082  ? 221  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.023  ? 263  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.50 1.54  . . 138 2524 100.00 . . . . 0.2012 . . . . . . . . . . . 0.2323 
'X-RAY DIFFRACTION' 1.54 1.57  . . 112 2572 100.00 . . . . 0.1902 . . . . . . . . . . . 0.2481 
'X-RAY DIFFRACTION' 1.57 1.62  . . 147 2523 100.00 . . . . 0.1809 . . . . . . . . . . . 0.1923 
'X-RAY DIFFRACTION' 1.62 1.66  . . 128 2551 100.00 . . . . 0.1783 . . . . . . . . . . . 0.1830 
'X-RAY DIFFRACTION' 1.66 1.72  . . 140 2527 100.00 . . . . 0.1768 . . . . . . . . . . . 0.1930 
'X-RAY DIFFRACTION' 1.72 1.78  . . 125 2571 100.00 . . . . 0.1708 . . . . . . . . . . . 0.1778 
'X-RAY DIFFRACTION' 1.78 1.85  . . 135 2550 100.00 . . . . 0.1591 . . . . . . . . . . . 0.1792 
'X-RAY DIFFRACTION' 1.85 1.93  . . 128 2578 100.00 . . . . 0.1612 . . . . . . . . . . . 0.1866 
'X-RAY DIFFRACTION' 1.93 2.04  . . 125 2564 100.00 . . . . 0.1597 . . . . . . . . . . . 0.1525 
'X-RAY DIFFRACTION' 2.04 2.16  . . 147 2565 100.00 . . . . 0.1452 . . . . . . . . . . . 0.1875 
'X-RAY DIFFRACTION' 2.16 2.33  . . 134 2588 100.00 . . . . 0.1463 . . . . . . . . . . . 0.1649 
'X-RAY DIFFRACTION' 2.33 2.56  . . 139 2569 99.00  . . . . 0.1532 . . . . . . . . . . . 0.1820 
'X-RAY DIFFRACTION' 2.56 2.93  . . 148 2608 100.00 . . . . 0.1544 . . . . . . . . . . . 0.1579 
'X-RAY DIFFRACTION' 2.93 3.69  . . 152 2656 100.00 . . . . 0.1580 . . . . . . . . . . . 0.1807 
'X-RAY DIFFRACTION' 3.69 18.94 . . 170 2796 99.00  . . . . 0.1817 . . . . . . . . . . . 0.1715 
# 
_struct.entry_id                     9KN7 
_struct.title                        'Crystal structure of Horse spleen L-ferritin mutant (Fr-E53F/E56F/E57F/R59L/E60F/E63F)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9KN7 
_struct_keywords.text            '24mer cage, Phenyl Alanine mutant, METAL BINDING PROTEIN' 
_struct_keywords.pdbx_keywords   'METAL BINDING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 2 ? 
E N N 2 ? 
F N N 2 ? 
G N N 2 ? 
H N N 2 ? 
I N N 2 ? 
J N N 3 ? 
K N N 3 ? 
L N N 4 ? 
M N N 5 ? 
N N N 5 ? 
O N N 5 ? 
P N N 5 ? 
Q N N 6 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    FRIL_HORSE 
_struct_ref.pdbx_db_accession          P02791 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SSQIRQNYSTEVEAAVNRLVNLYLRASYTYLSLGFYFDRDDVALEGVCHFFRELAEEKREGAERLLKMQNQRGGRALFQD
LQKPSQDEWGTTLDAMKAAIVLEKSLNQALLDLHALGSAQADPHLCDFLESHFLDEEVKLIKKMGDHLTNIQRLVGSQAG
LGEYLFERLTLKHD
;
_struct_ref.pdbx_align_begin           2 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9KN7 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 174 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P02791 
_struct_ref_seq.db_align_beg                  2 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  175 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       174 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9KN7 PHE A 53 ? UNP P02791 GLU 54 'engineered mutation' 53 1 
1 9KN7 PHE A 56 ? UNP P02791 GLU 57 'engineered mutation' 56 2 
1 9KN7 PHE A 57 ? UNP P02791 GLU 58 'engineered mutation' 57 3 
1 9KN7 LEU A 59 ? UNP P02791 ARG 60 'engineered mutation' 59 4 
1 9KN7 PHE A 60 ? UNP P02791 GLU 61 'engineered mutation' 60 5 
1 9KN7 PHE A 63 ? UNP P02791 GLU 64 'engineered mutation' 63 6 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   24-meric 
_pdbx_struct_assembly.oligomeric_count     24 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 128390 ? 
1 MORE         -568   ? 
1 'SSA (A^2)'  135260 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'native gel electrophoresis' 
_pdbx_struct_assembly_auth_evidence.details                'Size exclusion chromatography' 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1  'identity operation'         1_555  x,y,z    1.0000000000  0.0000000000  0.0000000000  0.0000000000 0.0000000000  1.0000000000  
0.0000000000  0.0000000000 0.0000000000  0.0000000000  1.0000000000  0.0000000000 
2  'crystal symmetry operation' 2_555  -x,-y,z  -1.0000000000 0.0000000000  0.0000000000  0.0000000000 0.0000000000  -1.0000000000 
0.0000000000  0.0000000000 0.0000000000  0.0000000000  1.0000000000  0.0000000000 
3  'crystal symmetry operation' 3_555  -x,y,-z  -1.0000000000 0.0000000000  0.0000000000  0.0000000000 0.0000000000  1.0000000000  
0.0000000000  0.0000000000 0.0000000000  0.0000000000  -1.0000000000 0.0000000000 
4  'crystal symmetry operation' 4_555  x,-y,-z  1.0000000000  0.0000000000  0.0000000000  0.0000000000 0.0000000000  -1.0000000000 
0.0000000000  0.0000000000 0.0000000000  0.0000000000  -1.0000000000 0.0000000000 
5  'crystal symmetry operation' 5_555  z,x,y    0.0000000000  0.0000000000  1.0000000000  0.0000000000 1.0000000000  0.0000000000  
0.0000000000  0.0000000000 0.0000000000  1.0000000000  0.0000000000  0.0000000000 
6  'crystal symmetry operation' 6_555  z,-x,-y  0.0000000000  0.0000000000  1.0000000000  0.0000000000 -1.0000000000 0.0000000000  
0.0000000000  0.0000000000 0.0000000000  -1.0000000000 0.0000000000  0.0000000000 
7  'crystal symmetry operation' 7_555  -z,-x,y  0.0000000000  0.0000000000  -1.0000000000 0.0000000000 -1.0000000000 0.0000000000  
0.0000000000  0.0000000000 0.0000000000  1.0000000000  0.0000000000  0.0000000000 
8  'crystal symmetry operation' 8_555  -z,x,-y  0.0000000000  0.0000000000  -1.0000000000 0.0000000000 1.0000000000  0.0000000000  
0.0000000000  0.0000000000 0.0000000000  -1.0000000000 0.0000000000  0.0000000000 
9  'crystal symmetry operation' 9_555  y,z,x    0.0000000000  1.0000000000  0.0000000000  0.0000000000 0.0000000000  0.0000000000  
1.0000000000  0.0000000000 1.0000000000  0.0000000000  0.0000000000  0.0000000000 
10 'crystal symmetry operation' 10_555 -y,z,-x  0.0000000000  -1.0000000000 0.0000000000  0.0000000000 0.0000000000  0.0000000000  
1.0000000000  0.0000000000 -1.0000000000 0.0000000000  0.0000000000  0.0000000000 
11 'crystal symmetry operation' 11_555 y,-z,-x  0.0000000000  1.0000000000  0.0000000000  0.0000000000 0.0000000000  0.0000000000  
-1.0000000000 0.0000000000 -1.0000000000 0.0000000000  0.0000000000  0.0000000000 
12 'crystal symmetry operation' 12_555 -y,-z,x  0.0000000000  -1.0000000000 0.0000000000  0.0000000000 0.0000000000  0.0000000000  
-1.0000000000 0.0000000000 1.0000000000  0.0000000000  0.0000000000  0.0000000000 
13 'crystal symmetry operation' 13_555 y,x,-z   0.0000000000  1.0000000000  0.0000000000  0.0000000000 1.0000000000  0.0000000000  
0.0000000000  0.0000000000 0.0000000000  0.0000000000  -1.0000000000 0.0000000000 
14 'crystal symmetry operation' 14_555 -y,-x,-z 0.0000000000  -1.0000000000 0.0000000000  0.0000000000 -1.0000000000 0.0000000000  
0.0000000000  0.0000000000 0.0000000000  0.0000000000  -1.0000000000 0.0000000000 
15 'crystal symmetry operation' 15_555 y,-x,z   0.0000000000  1.0000000000  0.0000000000  0.0000000000 -1.0000000000 0.0000000000  
0.0000000000  0.0000000000 0.0000000000  0.0000000000  1.0000000000  0.0000000000 
16 'crystal symmetry operation' 16_555 -y,x,z   0.0000000000  -1.0000000000 0.0000000000  0.0000000000 1.0000000000  0.0000000000  
0.0000000000  0.0000000000 0.0000000000  0.0000000000  1.0000000000  0.0000000000 
17 'crystal symmetry operation' 17_555 x,z,-y   1.0000000000  0.0000000000  0.0000000000  0.0000000000 0.0000000000  0.0000000000  
1.0000000000  0.0000000000 0.0000000000  -1.0000000000 0.0000000000  0.0000000000 
18 'crystal symmetry operation' 18_555 -x,z,y   -1.0000000000 0.0000000000  0.0000000000  0.0000000000 0.0000000000  0.0000000000  
1.0000000000  0.0000000000 0.0000000000  1.0000000000  0.0000000000  0.0000000000 
19 'crystal symmetry operation' 19_555 -x,-z,-y -1.0000000000 0.0000000000  0.0000000000  0.0000000000 0.0000000000  0.0000000000  
-1.0000000000 0.0000000000 0.0000000000  -1.0000000000 0.0000000000  0.0000000000 
20 'crystal symmetry operation' 20_555 x,-z,y   1.0000000000  0.0000000000  0.0000000000  0.0000000000 0.0000000000  0.0000000000  
-1.0000000000 0.0000000000 0.0000000000  1.0000000000  0.0000000000  0.0000000000 
21 'crystal symmetry operation' 21_555 z,y,-x   0.0000000000  0.0000000000  1.0000000000  0.0000000000 0.0000000000  1.0000000000  
0.0000000000  0.0000000000 -1.0000000000 0.0000000000  0.0000000000  0.0000000000 
22 'crystal symmetry operation' 22_555 z,-y,x   0.0000000000  0.0000000000  1.0000000000  0.0000000000 0.0000000000  -1.0000000000 
0.0000000000  0.0000000000 1.0000000000  0.0000000000  0.0000000000  0.0000000000 
23 'crystal symmetry operation' 23_555 -z,y,x   0.0000000000  0.0000000000  -1.0000000000 0.0000000000 0.0000000000  1.0000000000  
0.0000000000  0.0000000000 1.0000000000  0.0000000000  0.0000000000  0.0000000000 
24 'crystal symmetry operation' 24_555 -z,-y,-x 0.0000000000  0.0000000000  -1.0000000000 0.0000000000 0.0000000000  -1.0000000000 
0.0000000000  0.0000000000 -1.0000000000 0.0000000000  0.0000000000  0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 SER A 9   ? ASP A 38  ? SER A 9   ASP A 38  1 ? 30 
HELX_P HELX_P2 AA2 LEU A 44  ? GLY A 73  ? LEU A 44  GLY A 73  1 ? 30 
HELX_P HELX_P3 AA3 THR A 91  ? GLN A 120 ? THR A 91  GLN A 120 1 ? 30 
HELX_P HELX_P4 AA4 ASP A 122 ? PHE A 133 ? ASP A 122 PHE A 133 1 ? 12 
HELX_P HELX_P5 AA5 PHE A 133 ? GLY A 156 ? PHE A 133 GLY A 156 1 ? 24 
HELX_P HELX_P6 AA6 GLN A 158 ? THR A 170 ? GLN A 158 THR A 170 1 ? 13 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A GLU 11  OE1 ? ? ? 1_555 H CD . CD ? ? A GLU 11  A CD 207 1_555  ? ? ? ? ? ? ? 2.433 ? ? 
metalc2  metalc ? ? A ASP 38  OD1 ? ? ? 1_555 B CD . CD ? ? A ASP 38  A CD 201 1_555  ? ? ? ? ? ? ? 2.514 ? ? 
metalc3  metalc ? ? A CYS 48  SG  ? ? ? 1_555 B CD . CD ? ? A CYS 48  A CD 201 1_555  ? ? ? ? ? ? ? 2.611 ? ? 
metalc4  metalc ? ? A HIS 49  NE2 ? ? ? 1_555 I CD . CD ? ? A HIS 49  A CD 208 1_555  ? ? ? ? ? ? ? 2.459 ? ? 
metalc5  metalc ? ? A ASP 80  OD1 ? ? ? 1_555 C CD . CD ? ? A ASP 80  A CD 202 1_555  ? ? ? ? ? ? ? 2.308 ? ? 
metalc6  metalc ? ? A ASP 80  OD2 ? ? ? 1_555 C CD . CD ? ? A ASP 80  A CD 202 1_555  ? ? ? ? ? ? ? 2.298 ? ? 
metalc7  metalc ? ? A ASP 80  OD1 ? ? ? 1_555 C CD . CD ? ? A ASP 80  A CD 202 72_555 ? ? ? ? ? ? ? 2.307 ? ? 
metalc8  metalc ? ? A ASP 80  OD2 ? ? ? 1_555 C CD . CD ? ? A ASP 80  A CD 202 72_555 ? ? ? ? ? ? ? 2.298 ? ? 
metalc9  metalc ? ? A GLU 130 OE1 ? ? ? 1_555 E CD . CD ? ? A GLU 130 A CD 204 1_555  ? ? ? ? ? ? ? 2.245 ? ? 
metalc10 metalc ? ? A GLU 130 OE1 ? ? ? 1_555 E CD . CD ? ? A GLU 130 A CD 204 5_555  ? ? ? ? ? ? ? 2.245 ? ? 
metalc11 metalc ? ? A GLU 130 OE1 ? ? ? 1_555 F CD . CD ? ? A GLU 130 A CD 205 1_555  ? ? ? ? ? ? ? 2.420 ? ? 
metalc12 metalc ? ? A GLU 130 OE1 ? ? ? 1_555 F CD . CD ? ? A GLU 130 A CD 205 9_555  ? ? ? ? ? ? ? 2.554 ? ? 
metalc13 metalc ? ? A HIS 132 NE2 ? ? ? 1_555 G CD . CD ? ? A HIS 132 A CD 206 1_555  ? ? ? ? ? ? ? 2.637 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1 OD1 ? A ASP 38  ? A ASP 38  ? 1_555 CD ? B CD . ? A CD 201 ? 1_555 SG  ? A CYS 48  ? A CYS 48  ? 1_555 119.4 ? 
2 OD1 ? A ASP 80  ? A ASP 80  ? 1_555 CD ? C CD . ? A CD 202 ? 1_555 OD2 ? A ASP 80  ? A ASP 80  ? 1_555 55.0  ? 
3 OD1 ? A ASP 80  ? A ASP 80  ? 1_555 CD ? C CD . ? A CD 202 ? 1_555 OD1 ? A ASP 80  ? A ASP 80  ? 1_555 0.0   ? 
4 OD2 ? A ASP 80  ? A ASP 80  ? 1_555 CD ? C CD . ? A CD 202 ? 1_555 OD1 ? A ASP 80  ? A ASP 80  ? 1_555 55.0  ? 
5 OD1 ? A ASP 80  ? A ASP 80  ? 1_555 CD ? C CD . ? A CD 202 ? 1_555 OD2 ? A ASP 80  ? A ASP 80  ? 1_555 55.0  ? 
6 OD2 ? A ASP 80  ? A ASP 80  ? 1_555 CD ? C CD . ? A CD 202 ? 1_555 OD2 ? A ASP 80  ? A ASP 80  ? 1_555 0.0   ? 
7 OD1 ? A ASP 80  ? A ASP 80  ? 1_555 CD ? C CD . ? A CD 202 ? 1_555 OD2 ? A ASP 80  ? A ASP 80  ? 1_555 55.0  ? 
8 OE1 ? A GLU 130 ? A GLU 130 ? 1_555 CD ? E CD . ? A CD 204 ? 1_555 OE1 ? A GLU 130 ? A GLU 130 ? 1_555 0.0   ? 
9 OE1 ? A GLU 130 ? A GLU 130 ? 1_555 CD ? F CD . ? A CD 205 ? 1_555 OE1 ? A GLU 130 ? A GLU 130 ? 1_555 0.0   ? 
# 
_pdbx_entry_details.entry_id                   9KN7 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_rmsd_bond.id 
_pdbx_validate_rmsd_bond.PDB_model_num 
_pdbx_validate_rmsd_bond.auth_atom_id_1 
_pdbx_validate_rmsd_bond.auth_asym_id_1 
_pdbx_validate_rmsd_bond.auth_comp_id_1 
_pdbx_validate_rmsd_bond.auth_seq_id_1 
_pdbx_validate_rmsd_bond.PDB_ins_code_1 
_pdbx_validate_rmsd_bond.label_alt_id_1 
_pdbx_validate_rmsd_bond.auth_atom_id_2 
_pdbx_validate_rmsd_bond.auth_asym_id_2 
_pdbx_validate_rmsd_bond.auth_comp_id_2 
_pdbx_validate_rmsd_bond.auth_seq_id_2 
_pdbx_validate_rmsd_bond.PDB_ins_code_2 
_pdbx_validate_rmsd_bond.label_alt_id_2 
_pdbx_validate_rmsd_bond.bond_value 
_pdbx_validate_rmsd_bond.bond_target_value 
_pdbx_validate_rmsd_bond.bond_deviation 
_pdbx_validate_rmsd_bond.bond_standard_deviation 
_pdbx_validate_rmsd_bond.linker_flag 
1 1 NE A ARG 39  ? ? CZ  A ARG 39  ? ? 1.407 1.326 0.081 0.013 N 
2 1 CZ A ARG 153 ? ? NH1 A ARG 153 ? ? 1.412 1.326 0.086 0.013 N 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 NE  A ARG 18  ? B CZ A ARG 18  ? B NH1 A ARG 18  ? B 116.91 120.30 -3.39  0.50 N 
2 1 NE  A ARG 18  ? A CZ A ARG 18  ? A NH2 A ARG 18  ? A 117.20 120.30 -3.10  0.50 N 
3 1 NH1 A ARG 39  ? ? CZ A ARG 39  ? ? NH2 A ARG 39  ? ? 112.22 119.40 -7.18  1.10 N 
4 1 NE  A ARG 39  ? ? CZ A ARG 39  ? ? NH1 A ARG 39  ? ? 124.54 120.30 4.24   0.50 N 
5 1 CD  A ARG 153 ? ? NE A ARG 153 ? ? CZ  A ARG 153 ? ? 135.61 123.60 12.01  1.40 N 
6 1 NE  A ARG 153 ? ? CZ A ARG 153 ? ? NH1 A ARG 153 ? ? 128.00 120.30 7.70   0.50 N 
7 1 NE  A ARG 153 ? ? CZ A ARG 153 ? ? NH2 A ARG 153 ? ? 107.73 120.30 -12.57 0.50 N 
8 1 NE  A ARG 168 ? ? CZ A ARG 168 ? ? NH1 A ARG 168 ? ? 124.23 120.30 3.93   0.50 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 VAL A 42  ? ? -123.06 -62.58 
2 1 ASP A 122 ? ? -113.51 78.63  
3 1 PHE A 133 ? ? -125.86 -50.35 
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG A 39 ? ? 0.079 'SIDE CHAIN' 
2 1 ARG A 52 ? ? 0.161 'SIDE CHAIN' 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A CD  202 ? C CD  . 
2 1 A CD  203 ? D CD  . 
3 1 A CD  204 ? E CD  . 
4 1 A HOH 469 ? Q HOH . 
5 1 A HOH 482 ? Q HOH . 
6 1 A HOH 511 ? Q HOH . 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 523 ? 6.18 . 
2 1 O ? A HOH 524 ? 6.29 . 
3 1 O ? A HOH 525 ? 6.52 . 
4 1 O ? A HOH 526 ? 6.67 . 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CD  CD   CD N N 74  
CL  CL   CL N N 75  
CYS N    N  N N 76  
CYS CA   C  N R 77  
CYS C    C  N N 78  
CYS O    O  N N 79  
CYS CB   C  N N 80  
CYS SG   S  N N 81  
CYS OXT  O  N N 82  
CYS H    H  N N 83  
CYS H2   H  N N 84  
CYS HA   H  N N 85  
CYS HB2  H  N N 86  
CYS HB3  H  N N 87  
CYS HG   H  N N 88  
CYS HXT  H  N N 89  
EDO C1   C  N N 90  
EDO O1   O  N N 91  
EDO C2   C  N N 92  
EDO O2   O  N N 93  
EDO H11  H  N N 94  
EDO H12  H  N N 95  
EDO HO1  H  N N 96  
EDO H21  H  N N 97  
EDO H22  H  N N 98  
EDO HO2  H  N N 99  
GLN N    N  N N 100 
GLN CA   C  N S 101 
GLN C    C  N N 102 
GLN O    O  N N 103 
GLN CB   C  N N 104 
GLN CG   C  N N 105 
GLN CD   C  N N 106 
GLN OE1  O  N N 107 
GLN NE2  N  N N 108 
GLN OXT  O  N N 109 
GLN H    H  N N 110 
GLN H2   H  N N 111 
GLN HA   H  N N 112 
GLN HB2  H  N N 113 
GLN HB3  H  N N 114 
GLN HG2  H  N N 115 
GLN HG3  H  N N 116 
GLN HE21 H  N N 117 
GLN HE22 H  N N 118 
GLN HXT  H  N N 119 
GLU N    N  N N 120 
GLU CA   C  N S 121 
GLU C    C  N N 122 
GLU O    O  N N 123 
GLU CB   C  N N 124 
GLU CG   C  N N 125 
GLU CD   C  N N 126 
GLU OE1  O  N N 127 
GLU OE2  O  N N 128 
GLU OXT  O  N N 129 
GLU H    H  N N 130 
GLU H2   H  N N 131 
GLU HA   H  N N 132 
GLU HB2  H  N N 133 
GLU HB3  H  N N 134 
GLU HG2  H  N N 135 
GLU HG3  H  N N 136 
GLU HE2  H  N N 137 
GLU HXT  H  N N 138 
GLY N    N  N N 139 
GLY CA   C  N N 140 
GLY C    C  N N 141 
GLY O    O  N N 142 
GLY OXT  O  N N 143 
GLY H    H  N N 144 
GLY H2   H  N N 145 
GLY HA2  H  N N 146 
GLY HA3  H  N N 147 
GLY HXT  H  N N 148 
HIS N    N  N N 149 
HIS CA   C  N S 150 
HIS C    C  N N 151 
HIS O    O  N N 152 
HIS CB   C  N N 153 
HIS CG   C  Y N 154 
HIS ND1  N  Y N 155 
HIS CD2  C  Y N 156 
HIS CE1  C  Y N 157 
HIS NE2  N  Y N 158 
HIS OXT  O  N N 159 
HIS H    H  N N 160 
HIS H2   H  N N 161 
HIS HA   H  N N 162 
HIS HB2  H  N N 163 
HIS HB3  H  N N 164 
HIS HD1  H  N N 165 
HIS HD2  H  N N 166 
HIS HE1  H  N N 167 
HIS HE2  H  N N 168 
HIS HXT  H  N N 169 
HOH O    O  N N 170 
HOH H1   H  N N 171 
HOH H2   H  N N 172 
ILE N    N  N N 173 
ILE CA   C  N S 174 
ILE C    C  N N 175 
ILE O    O  N N 176 
ILE CB   C  N S 177 
ILE CG1  C  N N 178 
ILE CG2  C  N N 179 
ILE CD1  C  N N 180 
ILE OXT  O  N N 181 
ILE H    H  N N 182 
ILE H2   H  N N 183 
ILE HA   H  N N 184 
ILE HB   H  N N 185 
ILE HG12 H  N N 186 
ILE HG13 H  N N 187 
ILE HG21 H  N N 188 
ILE HG22 H  N N 189 
ILE HG23 H  N N 190 
ILE HD11 H  N N 191 
ILE HD12 H  N N 192 
ILE HD13 H  N N 193 
ILE HXT  H  N N 194 
LEU N    N  N N 195 
LEU CA   C  N S 196 
LEU C    C  N N 197 
LEU O    O  N N 198 
LEU CB   C  N N 199 
LEU CG   C  N N 200 
LEU CD1  C  N N 201 
LEU CD2  C  N N 202 
LEU OXT  O  N N 203 
LEU H    H  N N 204 
LEU H2   H  N N 205 
LEU HA   H  N N 206 
LEU HB2  H  N N 207 
LEU HB3  H  N N 208 
LEU HG   H  N N 209 
LEU HD11 H  N N 210 
LEU HD12 H  N N 211 
LEU HD13 H  N N 212 
LEU HD21 H  N N 213 
LEU HD22 H  N N 214 
LEU HD23 H  N N 215 
LEU HXT  H  N N 216 
LYS N    N  N N 217 
LYS CA   C  N S 218 
LYS C    C  N N 219 
LYS O    O  N N 220 
LYS CB   C  N N 221 
LYS CG   C  N N 222 
LYS CD   C  N N 223 
LYS CE   C  N N 224 
LYS NZ   N  N N 225 
LYS OXT  O  N N 226 
LYS H    H  N N 227 
LYS H2   H  N N 228 
LYS HA   H  N N 229 
LYS HB2  H  N N 230 
LYS HB3  H  N N 231 
LYS HG2  H  N N 232 
LYS HG3  H  N N 233 
LYS HD2  H  N N 234 
LYS HD3  H  N N 235 
LYS HE2  H  N N 236 
LYS HE3  H  N N 237 
LYS HZ1  H  N N 238 
LYS HZ2  H  N N 239 
LYS HZ3  H  N N 240 
LYS HXT  H  N N 241 
MET N    N  N N 242 
MET CA   C  N S 243 
MET C    C  N N 244 
MET O    O  N N 245 
MET CB   C  N N 246 
MET CG   C  N N 247 
MET SD   S  N N 248 
MET CE   C  N N 249 
MET OXT  O  N N 250 
MET H    H  N N 251 
MET H2   H  N N 252 
MET HA   H  N N 253 
MET HB2  H  N N 254 
MET HB3  H  N N 255 
MET HG2  H  N N 256 
MET HG3  H  N N 257 
MET HE1  H  N N 258 
MET HE2  H  N N 259 
MET HE3  H  N N 260 
MET HXT  H  N N 261 
PHE N    N  N N 262 
PHE CA   C  N S 263 
PHE C    C  N N 264 
PHE O    O  N N 265 
PHE CB   C  N N 266 
PHE CG   C  Y N 267 
PHE CD1  C  Y N 268 
PHE CD2  C  Y N 269 
PHE CE1  C  Y N 270 
PHE CE2  C  Y N 271 
PHE CZ   C  Y N 272 
PHE OXT  O  N N 273 
PHE H    H  N N 274 
PHE H2   H  N N 275 
PHE HA   H  N N 276 
PHE HB2  H  N N 277 
PHE HB3  H  N N 278 
PHE HD1  H  N N 279 
PHE HD2  H  N N 280 
PHE HE1  H  N N 281 
PHE HE2  H  N N 282 
PHE HZ   H  N N 283 
PHE HXT  H  N N 284 
PRO N    N  N N 285 
PRO CA   C  N S 286 
PRO C    C  N N 287 
PRO O    O  N N 288 
PRO CB   C  N N 289 
PRO CG   C  N N 290 
PRO CD   C  N N 291 
PRO OXT  O  N N 292 
PRO H    H  N N 293 
PRO HA   H  N N 294 
PRO HB2  H  N N 295 
PRO HB3  H  N N 296 
PRO HG2  H  N N 297 
PRO HG3  H  N N 298 
PRO HD2  H  N N 299 
PRO HD3  H  N N 300 
PRO HXT  H  N N 301 
SER N    N  N N 302 
SER CA   C  N S 303 
SER C    C  N N 304 
SER O    O  N N 305 
SER CB   C  N N 306 
SER OG   O  N N 307 
SER OXT  O  N N 308 
SER H    H  N N 309 
SER H2   H  N N 310 
SER HA   H  N N 311 
SER HB2  H  N N 312 
SER HB3  H  N N 313 
SER HG   H  N N 314 
SER HXT  H  N N 315 
SO4 S    S  N N 316 
SO4 O1   O  N N 317 
SO4 O2   O  N N 318 
SO4 O3   O  N N 319 
SO4 O4   O  N N 320 
THR N    N  N N 321 
THR CA   C  N S 322 
THR C    C  N N 323 
THR O    O  N N 324 
THR CB   C  N R 325 
THR OG1  O  N N 326 
THR CG2  C  N N 327 
THR OXT  O  N N 328 
THR H    H  N N 329 
THR H2   H  N N 330 
THR HA   H  N N 331 
THR HB   H  N N 332 
THR HG1  H  N N 333 
THR HG21 H  N N 334 
THR HG22 H  N N 335 
THR HG23 H  N N 336 
THR HXT  H  N N 337 
TRP N    N  N N 338 
TRP CA   C  N S 339 
TRP C    C  N N 340 
TRP O    O  N N 341 
TRP CB   C  N N 342 
TRP CG   C  Y N 343 
TRP CD1  C  Y N 344 
TRP CD2  C  Y N 345 
TRP NE1  N  Y N 346 
TRP CE2  C  Y N 347 
TRP CE3  C  Y N 348 
TRP CZ2  C  Y N 349 
TRP CZ3  C  Y N 350 
TRP CH2  C  Y N 351 
TRP OXT  O  N N 352 
TRP H    H  N N 353 
TRP H2   H  N N 354 
TRP HA   H  N N 355 
TRP HB2  H  N N 356 
TRP HB3  H  N N 357 
TRP HD1  H  N N 358 
TRP HE1  H  N N 359 
TRP HE3  H  N N 360 
TRP HZ2  H  N N 361 
TRP HZ3  H  N N 362 
TRP HH2  H  N N 363 
TRP HXT  H  N N 364 
TYR N    N  N N 365 
TYR CA   C  N S 366 
TYR C    C  N N 367 
TYR O    O  N N 368 
TYR CB   C  N N 369 
TYR CG   C  Y N 370 
TYR CD1  C  Y N 371 
TYR CD2  C  Y N 372 
TYR CE1  C  Y N 373 
TYR CE2  C  Y N 374 
TYR CZ   C  Y N 375 
TYR OH   O  N N 376 
TYR OXT  O  N N 377 
TYR H    H  N N 378 
TYR H2   H  N N 379 
TYR HA   H  N N 380 
TYR HB2  H  N N 381 
TYR HB3  H  N N 382 
TYR HD1  H  N N 383 
TYR HD2  H  N N 384 
TYR HE1  H  N N 385 
TYR HE2  H  N N 386 
TYR HH   H  N N 387 
TYR HXT  H  N N 388 
VAL N    N  N N 389 
VAL CA   C  N S 390 
VAL C    C  N N 391 
VAL O    O  N N 392 
VAL CB   C  N N 393 
VAL CG1  C  N N 394 
VAL CG2  C  N N 395 
VAL OXT  O  N N 396 
VAL H    H  N N 397 
VAL H2   H  N N 398 
VAL HA   H  N N 399 
VAL HB   H  N N 400 
VAL HG11 H  N N 401 
VAL HG12 H  N N 402 
VAL HG13 H  N N 403 
VAL HG21 H  N N 404 
VAL HG22 H  N N 405 
VAL HG23 H  N N 406 
VAL HXT  H  N N 407 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
EDO C1  O1   sing N N 83  
EDO C1  C2   sing N N 84  
EDO C1  H11  sing N N 85  
EDO C1  H12  sing N N 86  
EDO O1  HO1  sing N N 87  
EDO C2  O2   sing N N 88  
EDO C2  H21  sing N N 89  
EDO C2  H22  sing N N 90  
EDO O2  HO2  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
LEU N   CA   sing N N 182 
LEU N   H    sing N N 183 
LEU N   H2   sing N N 184 
LEU CA  C    sing N N 185 
LEU CA  CB   sing N N 186 
LEU CA  HA   sing N N 187 
LEU C   O    doub N N 188 
LEU C   OXT  sing N N 189 
LEU CB  CG   sing N N 190 
LEU CB  HB2  sing N N 191 
LEU CB  HB3  sing N N 192 
LEU CG  CD1  sing N N 193 
LEU CG  CD2  sing N N 194 
LEU CG  HG   sing N N 195 
LEU CD1 HD11 sing N N 196 
LEU CD1 HD12 sing N N 197 
LEU CD1 HD13 sing N N 198 
LEU CD2 HD21 sing N N 199 
LEU CD2 HD22 sing N N 200 
LEU CD2 HD23 sing N N 201 
LEU OXT HXT  sing N N 202 
LYS N   CA   sing N N 203 
LYS N   H    sing N N 204 
LYS N   H2   sing N N 205 
LYS CA  C    sing N N 206 
LYS CA  CB   sing N N 207 
LYS CA  HA   sing N N 208 
LYS C   O    doub N N 209 
LYS C   OXT  sing N N 210 
LYS CB  CG   sing N N 211 
LYS CB  HB2  sing N N 212 
LYS CB  HB3  sing N N 213 
LYS CG  CD   sing N N 214 
LYS CG  HG2  sing N N 215 
LYS CG  HG3  sing N N 216 
LYS CD  CE   sing N N 217 
LYS CD  HD2  sing N N 218 
LYS CD  HD3  sing N N 219 
LYS CE  NZ   sing N N 220 
LYS CE  HE2  sing N N 221 
LYS CE  HE3  sing N N 222 
LYS NZ  HZ1  sing N N 223 
LYS NZ  HZ2  sing N N 224 
LYS NZ  HZ3  sing N N 225 
LYS OXT HXT  sing N N 226 
MET N   CA   sing N N 227 
MET N   H    sing N N 228 
MET N   H2   sing N N 229 
MET CA  C    sing N N 230 
MET CA  CB   sing N N 231 
MET CA  HA   sing N N 232 
MET C   O    doub N N 233 
MET C   OXT  sing N N 234 
MET CB  CG   sing N N 235 
MET CB  HB2  sing N N 236 
MET CB  HB3  sing N N 237 
MET CG  SD   sing N N 238 
MET CG  HG2  sing N N 239 
MET CG  HG3  sing N N 240 
MET SD  CE   sing N N 241 
MET CE  HE1  sing N N 242 
MET CE  HE2  sing N N 243 
MET CE  HE3  sing N N 244 
MET OXT HXT  sing N N 245 
PHE N   CA   sing N N 246 
PHE N   H    sing N N 247 
PHE N   H2   sing N N 248 
PHE CA  C    sing N N 249 
PHE CA  CB   sing N N 250 
PHE CA  HA   sing N N 251 
PHE C   O    doub N N 252 
PHE C   OXT  sing N N 253 
PHE CB  CG   sing N N 254 
PHE CB  HB2  sing N N 255 
PHE CB  HB3  sing N N 256 
PHE CG  CD1  doub Y N 257 
PHE CG  CD2  sing Y N 258 
PHE CD1 CE1  sing Y N 259 
PHE CD1 HD1  sing N N 260 
PHE CD2 CE2  doub Y N 261 
PHE CD2 HD2  sing N N 262 
PHE CE1 CZ   doub Y N 263 
PHE CE1 HE1  sing N N 264 
PHE CE2 CZ   sing Y N 265 
PHE CE2 HE2  sing N N 266 
PHE CZ  HZ   sing N N 267 
PHE OXT HXT  sing N N 268 
PRO N   CA   sing N N 269 
PRO N   CD   sing N N 270 
PRO N   H    sing N N 271 
PRO CA  C    sing N N 272 
PRO CA  CB   sing N N 273 
PRO CA  HA   sing N N 274 
PRO C   O    doub N N 275 
PRO C   OXT  sing N N 276 
PRO CB  CG   sing N N 277 
PRO CB  HB2  sing N N 278 
PRO CB  HB3  sing N N 279 
PRO CG  CD   sing N N 280 
PRO CG  HG2  sing N N 281 
PRO CG  HG3  sing N N 282 
PRO CD  HD2  sing N N 283 
PRO CD  HD3  sing N N 284 
PRO OXT HXT  sing N N 285 
SER N   CA   sing N N 286 
SER N   H    sing N N 287 
SER N   H2   sing N N 288 
SER CA  C    sing N N 289 
SER CA  CB   sing N N 290 
SER CA  HA   sing N N 291 
SER C   O    doub N N 292 
SER C   OXT  sing N N 293 
SER CB  OG   sing N N 294 
SER CB  HB2  sing N N 295 
SER CB  HB3  sing N N 296 
SER OG  HG   sing N N 297 
SER OXT HXT  sing N N 298 
SO4 S   O1   doub N N 299 
SO4 S   O2   doub N N 300 
SO4 S   O3   sing N N 301 
SO4 S   O4   sing N N 302 
THR N   CA   sing N N 303 
THR N   H    sing N N 304 
THR N   H2   sing N N 305 
THR CA  C    sing N N 306 
THR CA  CB   sing N N 307 
THR CA  HA   sing N N 308 
THR C   O    doub N N 309 
THR C   OXT  sing N N 310 
THR CB  OG1  sing N N 311 
THR CB  CG2  sing N N 312 
THR CB  HB   sing N N 313 
THR OG1 HG1  sing N N 314 
THR CG2 HG21 sing N N 315 
THR CG2 HG22 sing N N 316 
THR CG2 HG23 sing N N 317 
THR OXT HXT  sing N N 318 
TRP N   CA   sing N N 319 
TRP N   H    sing N N 320 
TRP N   H2   sing N N 321 
TRP CA  C    sing N N 322 
TRP CA  CB   sing N N 323 
TRP CA  HA   sing N N 324 
TRP C   O    doub N N 325 
TRP C   OXT  sing N N 326 
TRP CB  CG   sing N N 327 
TRP CB  HB2  sing N N 328 
TRP CB  HB3  sing N N 329 
TRP CG  CD1  doub Y N 330 
TRP CG  CD2  sing Y N 331 
TRP CD1 NE1  sing Y N 332 
TRP CD1 HD1  sing N N 333 
TRP CD2 CE2  doub Y N 334 
TRP CD2 CE3  sing Y N 335 
TRP NE1 CE2  sing Y N 336 
TRP NE1 HE1  sing N N 337 
TRP CE2 CZ2  sing Y N 338 
TRP CE3 CZ3  doub Y N 339 
TRP CE3 HE3  sing N N 340 
TRP CZ2 CH2  doub Y N 341 
TRP CZ2 HZ2  sing N N 342 
TRP CZ3 CH2  sing Y N 343 
TRP CZ3 HZ3  sing N N 344 
TRP CH2 HH2  sing N N 345 
TRP OXT HXT  sing N N 346 
TYR N   CA   sing N N 347 
TYR N   H    sing N N 348 
TYR N   H2   sing N N 349 
TYR CA  C    sing N N 350 
TYR CA  CB   sing N N 351 
TYR CA  HA   sing N N 352 
TYR C   O    doub N N 353 
TYR C   OXT  sing N N 354 
TYR CB  CG   sing N N 355 
TYR CB  HB2  sing N N 356 
TYR CB  HB3  sing N N 357 
TYR CG  CD1  doub Y N 358 
TYR CG  CD2  sing Y N 359 
TYR CD1 CE1  sing Y N 360 
TYR CD1 HD1  sing N N 361 
TYR CD2 CE2  doub Y N 362 
TYR CD2 HD2  sing N N 363 
TYR CE1 CZ   doub Y N 364 
TYR CE1 HE1  sing N N 365 
TYR CE2 CZ   sing Y N 366 
TYR CE2 HE2  sing N N 367 
TYR CZ  OH   sing N N 368 
TYR OH  HH   sing N N 369 
TYR OXT HXT  sing N N 370 
VAL N   CA   sing N N 371 
VAL N   H    sing N N 372 
VAL N   H2   sing N N 373 
VAL CA  C    sing N N 374 
VAL CA  CB   sing N N 375 
VAL CA  HA   sing N N 376 
VAL C   O    doub N N 377 
VAL C   OXT  sing N N 378 
VAL CB  CG1  sing N N 379 
VAL CB  CG2  sing N N 380 
VAL CB  HB   sing N N 381 
VAL CG1 HG11 sing N N 382 
VAL CG1 HG12 sing N N 383 
VAL CG1 HG13 sing N N 384 
VAL CG2 HG21 sing N N 385 
VAL CG2 HG22 sing N N 386 
VAL CG2 HG23 sing N N 387 
VAL OXT HXT  sing N N 388 
# 
_pdbx_audit_support.funding_organization   'Japan Society for the Promotion of Science (JSPS)' 
_pdbx_audit_support.country                Japan 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1DAT 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9KN7 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.005534 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.005534 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.005534 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
CD 
CL 
N  
O  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . SER A 1 1   ? 57.138 18.879  21.735 1.00 49.42 ? 1   SER A N   1 
ATOM   2    C  CA  . SER A 1 1   ? 55.874 19.054  22.497 1.00 44.06 ? 1   SER A CA  1 
ATOM   3    C  C   . SER A 1 1   ? 54.687 18.639  21.625 1.00 42.60 ? 1   SER A C   1 
ATOM   4    O  O   . SER A 1 1   ? 54.851 18.251  20.466 1.00 44.10 ? 1   SER A O   1 
ATOM   5    N  N   . SER A 1 2   ? 53.482 18.737  22.189 1.00 32.22 ? 2   SER A N   1 
ATOM   6    C  CA  . SER A 1 2   ? 52.271 18.393  21.449 1.00 25.78 ? 2   SER A CA  1 
ATOM   7    C  C   . SER A 1 2   ? 52.049 19.381  20.301 1.00 25.19 ? 2   SER A C   1 
ATOM   8    O  O   . SER A 1 2   ? 52.062 20.609  20.470 1.00 28.02 ? 2   SER A O   1 
ATOM   9    C  CB  . SER A 1 2   ? 51.044 18.322  22.356 1.00 25.40 ? 2   SER A CB  1 
ATOM   10   O  OG  . SER A 1 2   ? 49.792 18.251  21.669 1.00 18.14 ? 2   SER A OG  1 
ATOM   11   N  N   . GLN A 1 3   ? 51.620 18.813  19.186 1.00 18.71 ? 3   GLN A N   1 
ATOM   12   C  CA  . GLN A 1 3   ? 51.339 19.534  17.966 1.00 16.78 ? 3   GLN A CA  1 
ATOM   13   C  C   . GLN A 1 3   ? 49.970 20.201  17.965 1.00 14.79 ? 3   GLN A C   1 
ATOM   14   O  O   . GLN A 1 3   ? 49.758 21.096  17.163 1.00 16.19 ? 3   GLN A O   1 
ATOM   15   C  CB  . GLN A 1 3   ? 51.423 18.607  16.753 1.00 19.86 ? 3   GLN A CB  1 
ATOM   16   C  CG  . GLN A 1 3   ? 50.256 17.655  16.589 1.00 28.22 ? 3   GLN A CG  1 
ATOM   17   C  CD  . GLN A 1 3   ? 50.470 16.485  15.643 1.00 28.94 ? 3   GLN A CD  1 
ATOM   18   O  OE1 . GLN A 1 3   ? 49.682 15.525  15.686 1.00 15.64 ? 3   GLN A OE1 1 
ATOM   19   N  NE2 . GLN A 1 3   ? 51.499 16.549  14.794 1.00 30.85 ? 3   GLN A NE2 1 
ATOM   20   N  N   . ILE A 1 4   ? 49.056 19.830  18.865 1.00 11.59 ? 4   ILE A N   1 
ATOM   21   C  CA  . ILE A 1 4   ? 47.732 20.450  18.907 1.00 9.84  ? 4   ILE A CA  1 
ATOM   22   C  C   . ILE A 1 4   ? 47.513 21.292  20.173 1.00 9.44  ? 4   ILE A C   1 
ATOM   23   O  O   . ILE A 1 4   ? 46.608 22.149  20.192 1.00 10.26 ? 4   ILE A O   1 
ATOM   24   C  CB  . ILE A 1 4   ? 46.594 19.409  18.788 1.00 9.81  ? 4   ILE A CB  1 
ATOM   25   C  CG1 . ILE A 1 4   ? 46.480 18.468  20.005 1.00 10.84 ? 4   ILE A CG1 1 
ATOM   26   C  CG2 . ILE A 1 4   ? 46.744 18.645  17.475 1.00 11.42 ? 4   ILE A CG2 1 
ATOM   27   C  CD1 . ILE A 1 4   ? 45.267 17.563  19.967 1.00 12.36 ? 4   ILE A CD1 1 
ATOM   28   N  N   . ARG A 1 5   ? 48.217 20.986  21.259 1.00 8.49  ? 5   ARG A N   1 
ATOM   29   C  CA  . ARG A 1 5   ? 47.875 21.531  22.568 1.00 8.32  ? 5   ARG A CA  1 
ATOM   30   C  C   . ARG A 1 5   ? 47.995 23.045  22.523 1.00 8.33  ? 5   ARG A C   1 
ATOM   31   O  O   . ARG A 1 5   ? 49.022 23.588  22.078 1.00 9.72  ? 5   ARG A O   1 
ATOM   32   C  CB  . ARG A 1 5   ? 48.810 20.949  23.604 1.00 9.32  ? 5   ARG A CB  1 
ATOM   33   C  CG  . ARG A 1 5   ? 48.453 21.249  25.036 1.00 9.81  ? 5   ARG A CG  1 
ATOM   34   C  CD  . ARG A 1 5   ? 49.419 20.539  25.964 1.00 11.33 ? 5   ARG A CD  1 
ATOM   35   N  NE  . ARG A 1 5   ? 49.018 20.763  27.347 1.00 11.03 ? 5   ARG A NE  1 
ATOM   36   C  CZ  . ARG A 1 5   ? 49.185 19.872  28.308 1.00 10.19 ? 5   ARG A CZ  1 
ATOM   37   N  NH1 . ARG A 1 5   ? 49.845 18.742  28.051 1.00 10.66 ? 5   ARG A NH1 1 
ATOM   38   N  NH2 . ARG A 1 5   ? 48.759 20.184  29.537 1.00 10.21 ? 5   ARG A NH2 1 
ATOM   39   N  N   . GLN A 1 6   ? 46.978 23.735  23.063 1.00 7.57  ? 6   GLN A N   1 
ATOM   40   C  CA  . GLN A 1 6   ? 46.938 25.192  23.058 1.00 7.61  ? 6   GLN A CA  1 
ATOM   41   C  C   . GLN A 1 6   ? 46.042 25.646  24.191 1.00 7.99  ? 6   GLN A C   1 
ATOM   42   O  O   . GLN A 1 6   ? 44.884 25.232  24.276 1.00 7.58  ? 6   GLN A O   1 
ATOM   43   C  CB  . GLN A 1 6   ? 46.411 25.698  21.717 1.00 7.65  ? 6   GLN A CB  1 
ATOM   44   C  CG  . GLN A 1 6   ? 46.517 27.213  21.531 1.00 8.49  ? 6   GLN A CG  1 
ATOM   45   C  CD  . GLN A 1 6   ? 46.076 27.620  20.139 1.00 9.71  ? 6   GLN A CD  1 
ATOM   46   O  OE1 . GLN A 1 6   ? 45.320 26.951  19.419 1.00 10.09 ? 6   GLN A OE1 1 
ATOM   47   N  NE2 . GLN A 1 6   ? 46.602 28.749  19.711 1.00 11.07 ? 6   GLN A NE2 1 
ATOM   48   N  N   . ASN A 1 7   ? 46.573 26.505  25.058 1.00 7.65  ? 7   ASN A N   1 
ATOM   49   C  CA  . ASN A 1 7   ? 45.825 27.037  26.191 1.00 7.47  ? 7   ASN A CA  1 
ATOM   50   C  C   . ASN A 1 7   ? 45.359 25.962  27.170 1.00 7.54  ? 7   ASN A C   1 
ATOM   51   O  O   . ASN A 1 7   ? 44.302 26.132  27.789 1.00 8.21  ? 7   ASN A O   1 
ATOM   52   C  CB  . ASN A 1 7   ? 44.637 27.876  25.762 1.00 7.78  ? 7   ASN A CB  1 
ATOM   53   C  CG  . ASN A 1 7   ? 44.146 28.763  26.877 1.00 7.91  ? 7   ASN A CG  1 
ATOM   54   O  OD1 . ASN A 1 7   ? 44.938 29.289  27.670 1.00 9.79  ? 7   ASN A OD1 1 
ATOM   55   N  ND2 . ASN A 1 7   ? 42.845 28.930  26.967 1.00 8.26  ? 7   ASN A ND2 1 
ATOM   56   N  N   . TYR A 1 8   ? 46.117 24.865  27.285 1.00 7.55  ? 8   TYR A N   1 
ATOM   57   C  CA  . TYR A 1 8   ? 45.709 23.733  28.108 1.00 8.57  ? 8   TYR A CA  1 
ATOM   58   C  C   . TYR A 1 8   ? 46.763 23.480  29.170 1.00 8.56  ? 8   TYR A C   1 
ATOM   59   O  O   . TYR A 1 8   ? 47.815 22.898  28.877 1.00 9.22  ? 8   TYR A O   1 
ATOM   60   C  CB  . TYR A 1 8   ? 45.467 22.500  27.243 1.00 8.67  ? 8   TYR A CB  1 
ATOM   61   C  CG  . TYR A 1 8   ? 44.720 21.380  27.958 1.00 8.54  ? 8   TYR A CG  1 
ATOM   62   C  CD1 . TYR A 1 8   ? 43.457 21.604  28.476 1.00 8.31  ? 8   TYR A CD1 1 
ATOM   63   C  CD2 . TYR A 1 8   ? 45.257 20.107  28.083 1.00 8.27  ? 8   TYR A CD2 1 
ATOM   64   C  CE1 . TYR A 1 8   ? 42.740 20.582  29.064 1.00 8.00  ? 8   TYR A CE1 1 
ATOM   65   C  CE2 . TYR A 1 8   ? 44.568 19.086  28.712 1.00 7.46  ? 8   TYR A CE2 1 
ATOM   66   C  CZ  . TYR A 1 8   ? 43.305 19.316  29.210 1.00 7.95  ? 8   TYR A CZ  1 
ATOM   67   O  OH  . TYR A 1 8   ? 42.563 18.341  29.811 1.00 8.94  ? 8   TYR A OH  1 
ATOM   68   N  N   . SER A 1 9   ? 46.531 23.959  30.374 1.00 8.17  ? 9   SER A N   1 
ATOM   69   C  CA  . SER A 1 9   ? 47.559 23.906  31.408 1.00 8.46  ? 9   SER A CA  1 
ATOM   70   C  C   . SER A 1 9   ? 47.837 22.489  31.904 1.00 8.93  ? 9   SER A C   1 
ATOM   71   O  O   . SER A 1 9   ? 46.995 21.604  31.860 1.00 8.43  ? 9   SER A O   1 
ATOM   72   C  CB  . SER A 1 9   ? 47.171 24.785  32.568 1.00 8.84  ? 9   SER A CB  1 
ATOM   73   O  OG  . SER A 1 9   ? 46.028 24.255  33.234 1.00 10.91 ? 9   SER A OG  1 
ATOM   74   N  N   . THR A 1 10  ? 49.033 22.299  32.488 1.00 10.28 ? 10  THR A N   1 
ATOM   75   C  CA  . THR A 1 10  ? 49.342 21.043  33.152 1.00 10.28 ? 10  THR A CA  1 
ATOM   76   C  C   . THR A 1 10  ? 48.405 20.838  34.344 1.00 9.12  ? 10  THR A C   1 
ATOM   77   O  O   . THR A 1 10  ? 48.074 19.693  34.642 1.00 9.57  ? 10  THR A O   1 
ATOM   78   C  CB  . THR A 1 10  ? 50.809 20.990  33.562 1.00 13.23 ? 10  THR A CB  1 
ATOM   79   O  OG1 . THR A 1 10  ? 51.071 22.098  34.399 1.00 16.41 ? 10  THR A OG1 1 
ATOM   80   C  CG2 . THR A 1 10  ? 51.699 21.137  32.352 1.00 13.06 ? 10  THR A CG2 1 
ATOM   81   N  N   . GLU A 1 11  ? 48.012 21.908  35.044 1.00 9.80  ? 11  GLU A N   1 
ATOM   82   C  CA  . GLU A 1 11  ? 47.127 21.794  36.190 1.00 9.40  ? 11  GLU A CA  1 
ATOM   83   C  C   . GLU A 1 11  ? 45.773 21.213  35.763 1.00 8.24  ? 11  GLU A C   1 
ATOM   84   O  O   . GLU A 1 11  ? 45.235 20.336  36.432 1.00 9.03  ? 11  GLU A O   1 
ATOM   85   C  CB  . GLU A 1 11  ? 46.929 23.114  36.935 1.00 11.10 ? 11  GLU A CB  1 
ATOM   86   C  CG  . GLU A 1 11  ? 48.190 23.679  37.566 1.00 13.29 ? 11  GLU A CG  1 
ATOM   87   C  CD  . GLU A 1 11  ? 49.086 24.458  36.627 1.00 16.24 ? 11  GLU A CD  1 
ATOM   88   O  OE1 . GLU A 1 11  ? 48.865 24.667  35.423 1.00 14.14 ? 11  GLU A OE1 1 
ATOM   89   O  OE2 . GLU A 1 11  ? 50.161 24.868  37.167 1.00 19.82 ? 11  GLU A OE2 1 
ATOM   90   N  N   . VAL A 1 12  ? 45.203 21.749  34.679 1.00 8.13  ? 12  VAL A N   1 
ATOM   91   C  CA  . VAL A 1 12  ? 43.924 21.232  34.183 1.00 7.91  ? 12  VAL A CA  1 
ATOM   92   C  C   . VAL A 1 12  ? 44.093 19.788  33.733 1.00 8.07  ? 12  VAL A C   1 
ATOM   93   O  O   . VAL A 1 12  ? 43.260 18.947  34.045 1.00 7.81  ? 12  VAL A O   1 
ATOM   94   C  CB  . VAL A 1 12  ? 43.323 22.161  33.123 1.00 8.56  ? 12  VAL A CB  1 
ATOM   95   C  CG1 . VAL A 1 12  ? 42.188 21.491  32.364 1.00 8.26  ? 12  VAL A CG1 1 
ATOM   96   C  CG2 . VAL A 1 12  ? 42.794 23.429  33.751 1.00 8.25  ? 12  VAL A CG2 1 
ATOM   97   N  N   . GLU A 1 13  ? 45.150 19.497  32.958 1.00 7.08  ? 13  GLU A N   1 
ATOM   98   C  CA  . GLU A 1 13  ? 45.370 18.142  32.477 1.00 7.33  ? 13  GLU A CA  1 
ATOM   99   C  C   . GLU A 1 13  ? 45.380 17.137  33.639 1.00 7.42  ? 13  GLU A C   1 
ATOM   100  O  O   . GLU A 1 13  ? 44.710 16.101  33.574 1.00 7.80  ? 13  GLU A O   1 
ATOM   101  C  CB  . GLU A 1 13  ? 46.699 18.121  31.717 1.00 8.22  ? 13  GLU A CB  1 
ATOM   102  C  CG  . GLU A 1 13  ? 47.134 16.727  31.275 1.00 8.69  ? 13  GLU A CG  1 
ATOM   103  C  CD  . GLU A 1 13  ? 48.515 16.715  30.625 1.00 11.62 ? 13  GLU A CD  1 
ATOM   104  O  OE1 . GLU A 1 13  ? 49.276 17.692  30.878 1.00 12.48 ? 13  GLU A OE1 1 
ATOM   105  O  OE2 . GLU A 1 13  ? 48.891 15.786  29.881 1.00 12.74 ? 13  GLU A OE2 1 
ATOM   106  N  N   . ALA A 1 14  ? 46.095 17.465  34.719 1.00 7.66  ? 14  ALA A N   1 
ATOM   107  C  CA  . ALA A 1 14  ? 46.149 16.579  35.875 1.00 7.15  ? 14  ALA A CA  1 
ATOM   108  C  C   . ALA A 1 14  ? 44.799 16.451  36.565 1.00 7.26  ? 14  ALA A C   1 
ATOM   109  O  O   . ALA A 1 14  ? 44.407 15.343  36.985 1.00 8.31  ? 14  ALA A O   1 
ATOM   110  C  CB  . ALA A 1 14  ? 47.223 17.055  36.855 1.00 7.60  ? 14  ALA A CB  1 
ATOM   111  N  N   . ALA A 1 15  ? 44.112 17.583  36.707 1.00 7.31  ? 15  ALA A N   1 
ATOM   112  C  CA  . ALA A 1 15  ? 42.831 17.562  37.393 1.00 7.83  ? 15  ALA A CA  1 
ATOM   113  C  C   . ALA A 1 15  ? 41.807 16.774  36.594 1.00 7.85  ? 15  ALA A C   1 
ATOM   114  O  O   . ALA A 1 15  ? 40.944 16.105  37.164 1.00 7.93  ? 15  ALA A O   1 
ATOM   115  C  CB  . ALA A 1 15  ? 42.351 18.971  37.623 1.00 8.89  ? 15  ALA A CB  1 
ATOM   116  N  N   . VAL A 1 16  ? 41.899 16.820  35.255 1.00 6.92  ? 16  VAL A N   1 
ATOM   117  C  CA  . VAL A 1 16  ? 41.032 16.002  34.408 1.00 6.99  ? 16  VAL A CA  1 
ATOM   118  C  C   . VAL A 1 16  ? 41.271 14.507  34.639 1.00 7.19  ? 16  VAL A C   1 
ATOM   119  O  O   . VAL A 1 16  ? 40.334 13.726  34.768 1.00 7.31  ? 16  VAL A O   1 
ATOM   120  C  CB  . VAL A 1 16  ? 41.177 16.397  32.929 1.00 7.73  ? 16  VAL A CB  1 
ATOM   121  C  CG1 . VAL A 1 16  ? 40.514 15.401  31.996 1.00 8.18  ? 16  VAL A CG1 1 
ATOM   122  C  CG2 . VAL A 1 16  ? 40.575 17.776  32.700 1.00 7.95  ? 16  VAL A CG2 1 
ATOM   123  N  N   . ASN A 1 17  ? 42.541 14.100  34.697 1.00 7.19  ? 17  ASN A N   1 
ATOM   124  C  CA  . ASN A 1 17  ? 42.861 12.719  35.005 1.00 7.07  ? 17  ASN A CA  1 
ATOM   125  C  C   . ASN A 1 17  ? 42.345 12.293  36.391 1.00 7.48  ? 17  ASN A C   1 
ATOM   126  O  O   . ASN A 1 17  ? 41.803 11.194  36.552 1.00 7.29  ? 17  ASN A O   1 
ATOM   127  C  CB  . ASN A 1 17  ? 44.348 12.455  34.902 1.00 7.64  ? 17  ASN A CB  1 
ATOM   128  C  CG  . ASN A 1 17  ? 44.842 12.376  33.477 1.00 7.91  ? 17  ASN A CG  1 
ATOM   129  O  OD1 . ASN A 1 17  ? 44.119 11.912  32.594 1.00 7.20  ? 17  ASN A OD1 1 
ATOM   130  N  ND2 . ASN A 1 17  ? 46.069 12.790  33.288 1.00 8.79  ? 17  ASN A ND2 1 
ATOM   131  N  N   . ARG A 1 18  ? 42.410 13.182  37.383 1.00 7.70  ? 18  ARG A N   1 
ATOM   132  C  CA  A ARG A 1 18  ? 41.898 12.883  38.719 0.60 8.32  ? 18  ARG A CA  1 
ATOM   133  C  CA  B ARG A 1 18  ? 41.902 12.881  38.720 0.40 8.56  ? 18  ARG A CA  1 
ATOM   134  C  C   . ARG A 1 18  ? 40.377 12.726  38.648 1.00 8.12  ? 18  ARG A C   1 
ATOM   135  O  O   . ARG A 1 18  ? 39.775 11.847  39.277 1.00 7.93  ? 18  ARG A O   1 
ATOM   136  C  CB  A ARG A 1 18  ? 42.303 13.967  39.723 0.60 10.23 ? 18  ARG A CB  1 
ATOM   137  C  CB  B ARG A 1 18  ? 42.351 13.958  39.718 0.40 10.58 ? 18  ARG A CB  1 
ATOM   138  C  CG  A ARG A 1 18  ? 43.795 13.903  39.984 0.60 13.18 ? 18  ARG A CG  1 
ATOM   139  C  CG  B ARG A 1 18  ? 41.661 13.930  41.075 0.40 13.56 ? 18  ARG A CG  1 
ATOM   140  C  CD  A ARG A 1 18  ? 44.173 14.544  41.279 0.60 15.68 ? 18  ARG A CD  1 
ATOM   141  C  CD  B ARG A 1 18  ? 42.050 15.172  41.889 0.40 16.19 ? 18  ARG A CD  1 
ATOM   142  N  NE  A ARG A 1 18  ? 44.043 15.984  41.111 0.60 16.74 ? 18  ARG A NE  1 
ATOM   143  N  NE  B ARG A 1 18  ? 40.948 15.601  42.756 0.40 21.34 ? 18  ARG A NE  1 
ATOM   144  C  CZ  A ARG A 1 18  ? 44.969 16.708  40.489 0.60 16.17 ? 18  ARG A CZ  1 
ATOM   145  C  CZ  B ARG A 1 18  ? 40.433 14.761  43.619 0.40 22.66 ? 18  ARG A CZ  1 
ATOM   146  N  NH1 A ARG A 1 18  ? 46.177 16.216  40.293 0.60 19.36 ? 18  ARG A NH1 1 
ATOM   147  N  NH1 B ARG A 1 18  ? 40.974 13.561  43.679 0.40 23.58 ? 18  ARG A NH1 1 
ATOM   148  N  NH2 A ARG A 1 18  ? 44.680 17.925  40.226 0.60 14.11 ? 18  ARG A NH2 1 
ATOM   149  N  NH2 B ARG A 1 18  ? 39.413 15.097  44.392 0.40 25.24 ? 18  ARG A NH2 1 
ATOM   150  N  N   . LEU A 1 19  ? 39.744 13.594  37.878 1.00 7.16  ? 19  LEU A N   1 
ATOM   151  C  CA  . LEU A 1 19  ? 38.291 13.540  37.749 1.00 7.21  ? 19  LEU A CA  1 
ATOM   152  C  C   . LEU A 1 19  ? 37.848 12.243  37.069 1.00 7.29  ? 19  LEU A C   1 
ATOM   153  O  O   . LEU A 1 19  ? 36.797 11.688  37.441 1.00 7.56  ? 19  LEU A O   1 
ATOM   154  C  CB  . LEU A 1 19  ? 37.766 14.757  37.003 1.00 8.09  ? 19  LEU A CB  1 
ATOM   155  C  CG  . LEU A 1 19  ? 36.257 14.986  37.045 1.00 9.33  ? 19  LEU A CG  1 
ATOM   156  C  CD1 . LEU A 1 19  ? 35.740 15.148  38.461 1.00 8.71  ? 19  LEU A CD1 1 
ATOM   157  C  CD2 . LEU A 1 19  ? 35.860 16.193  36.251 1.00 10.51 ? 19  LEU A CD2 1 
ATOM   158  N  N   . VAL A 1 20  ? 38.589 11.794  36.061 1.00 6.99  ? 20  VAL A N   1 
ATOM   159  C  CA  . VAL A 1 20  ? 38.308 10.489  35.456 1.00 7.22  ? 20  VAL A CA  1 
ATOM   160  C  C   . VAL A 1 20  ? 38.331 9.402   36.521 1.00 7.34  ? 20  VAL A C   1 
ATOM   161  O  O   . VAL A 1 20  ? 37.449 8.558   36.562 1.00 7.36  ? 20  VAL A O   1 
ATOM   162  C  CB  . VAL A 1 20  ? 39.274 10.201  34.303 1.00 6.97  ? 20  VAL A CB  1 
ATOM   163  C  CG1 . VAL A 1 20  ? 39.209 8.724   33.854 1.00 7.33  ? 20  VAL A CG1 1 
ATOM   164  C  CG2 . VAL A 1 20  ? 39.030 11.140  33.150 1.00 7.37  ? 20  VAL A CG2 1 
ATOM   165  N  N   . ASN A 1 21  ? 39.333 9.420   37.383 1.00 7.13  ? 21  ASN A N   1 
ATOM   166  C  CA  . ASN A 1 21  ? 39.438 8.438   38.450 1.00 6.96  ? 21  ASN A CA  1 
ATOM   167  C  C   . ASN A 1 21  ? 38.194 8.512   39.341 1.00 7.68  ? 21  ASN A C   1 
ATOM   168  O  O   . ASN A 1 21  ? 37.633 7.477   39.720 1.00 8.73  ? 21  ASN A O   1 
ATOM   169  C  CB  . ASN A 1 21  ? 40.720 8.589   39.256 1.00 7.76  ? 21  ASN A CB  1 
ATOM   170  C  CG  . ASN A 1 21  ? 41.012 7.374   40.121 1.00 8.29  ? 21  ASN A CG  1 
ATOM   171  O  OD1 . ASN A 1 21  ? 41.696 6.394   39.713 1.00 11.30 ? 21  ASN A OD1 1 
ATOM   172  N  ND2 . ASN A 1 21  ? 40.623 7.449   41.359 1.00 8.27  ? 21  ASN A ND2 1 
ATOM   173  N  N   . LEU A 1 22  ? 37.771 9.723   39.705 1.00 7.80  ? 22  LEU A N   1 
ATOM   174  C  CA  . LEU A 1 22  ? 36.593 9.867   40.544 1.00 8.88  ? 22  LEU A CA  1 
ATOM   175  C  C   . LEU A 1 22  ? 35.339 9.313   39.872 1.00 7.79  ? 22  LEU A C   1 
ATOM   176  O  O   . LEU A 1 22  ? 34.507 8.669   40.539 1.00 7.90  ? 22  LEU A O   1 
ATOM   177  C  CB  . LEU A 1 22  ? 36.406 11.340  40.875 1.00 10.07 ? 22  LEU A CB  1 
ATOM   178  C  CG  . LEU A 1 22  ? 37.437 11.945  41.817 1.00 13.59 ? 22  LEU A CG  1 
ATOM   179  C  CD1 . LEU A 1 22  ? 37.177 13.438  41.985 1.00 14.82 ? 22  LEU A CD1 1 
ATOM   180  C  CD2 . LEU A 1 22  ? 37.417 11.273  43.192 1.00 16.16 ? 22  LEU A CD2 1 
ATOM   181  N  N   . TYR A 1 23  ? 35.163 9.567   38.576 1.00 7.59  ? 23  TYR A N   1 
ATOM   182  C  CA  . TYR A 1 23  ? 33.989 9.056   37.884 1.00 7.45  ? 23  TYR A CA  1 
ATOM   183  C  C   . TYR A 1 23  ? 34.035 7.535   37.765 1.00 7.81  ? 23  TYR A C   1 
ATOM   184  O  O   . TYR A 1 23  ? 32.990 6.886   37.872 1.00 8.27  ? 23  TYR A O   1 
ATOM   185  C  CB  . TYR A 1 23  ? 33.859 9.717   36.504 1.00 7.66  ? 23  TYR A CB  1 
ATOM   186  C  CG  . TYR A 1 23  ? 33.026 10.980  36.549 1.00 8.35  ? 23  TYR A CG  1 
ATOM   187  C  CD1 . TYR A 1 23  ? 33.475 12.149  37.169 1.00 9.63  ? 23  TYR A CD1 1 
ATOM   188  C  CD2 . TYR A 1 23  ? 31.745 10.977  36.038 1.00 8.44  ? 23  TYR A CD2 1 
ATOM   189  C  CE1 . TYR A 1 23  ? 32.667 13.264  37.329 1.00 11.70 ? 23  TYR A CE1 1 
ATOM   190  C  CE2 . TYR A 1 23  ? 30.923 12.086  36.199 1.00 9.81  ? 23  TYR A CE2 1 
ATOM   191  C  CZ  . TYR A 1 23  ? 31.365 13.216  36.846 1.00 11.86 ? 23  TYR A CZ  1 
ATOM   192  O  OH  . TYR A 1 23  ? 30.581 14.352  37.038 1.00 13.20 ? 23  TYR A OH  1 
ATOM   193  N  N   . LEU A 1 24  ? 35.209 6.966   37.464 1.00 8.07  ? 24  LEU A N   1 
ATOM   194  C  CA  . LEU A 1 24  ? 35.309 5.521   37.409 1.00 8.20  ? 24  LEU A CA  1 
ATOM   195  C  C   . LEU A 1 24  ? 35.071 4.907   38.786 1.00 7.91  ? 24  LEU A C   1 
ATOM   196  O  O   . LEU A 1 24  ? 34.414 3.863   38.902 1.00 8.56  ? 24  LEU A O   1 
ATOM   197  C  CB  . LEU A 1 24  ? 36.652 5.077   36.844 1.00 8.56  ? 24  LEU A CB  1 
ATOM   198  C  CG  . LEU A 1 24  ? 36.853 5.437   35.373 1.00 9.97  ? 24  LEU A CG  1 
ATOM   199  C  CD1 . LEU A 1 24  ? 38.265 5.083   34.985 1.00 10.82 ? 24  LEU A CD1 1 
ATOM   200  C  CD2 . LEU A 1 24  ? 35.854 4.750   34.448 1.00 11.17 ? 24  LEU A CD2 1 
ATOM   201  N  N   . ARG A 1 25  ? 35.553 5.540   39.854 1.00 7.50  ? 25  ARG A N   1 
ATOM   202  C  CA  . ARG A 1 25  ? 35.288 5.063   41.213 1.00 8.70  ? 25  ARG A CA  1 
ATOM   203  C  C   . ARG A 1 25  ? 33.788 5.085   41.474 1.00 8.72  ? 25  ARG A C   1 
ATOM   204  O  O   . ARG A 1 25  ? 33.229 4.170   42.095 1.00 8.06  ? 25  ARG A O   1 
ATOM   205  C  CB  . ARG A 1 25  ? 35.998 5.949   42.244 1.00 10.97 ? 25  ARG A CB  1 
ATOM   206  C  CG  . ARG A 1 25  ? 37.477 5.717   42.482 1.00 15.68 ? 25  ARG A CG  1 
ATOM   207  C  CD  . ARG A 1 25  ? 38.081 6.762   43.444 1.00 17.40 ? 25  ARG A CD  1 
ATOM   208  N  NE  . ARG A 1 25  ? 37.464 6.813   44.773 1.00 21.65 ? 25  ARG A NE  1 
ATOM   209  C  CZ  . ARG A 1 25  ? 37.665 7.769   45.693 1.00 26.86 ? 25  ARG A CZ  1 
ATOM   210  N  NH1 . ARG A 1 25  ? 38.467 8.790   45.422 1.00 21.71 ? 25  ARG A NH1 1 
ATOM   211  N  NH2 . ARG A 1 25  ? 37.067 7.665   46.895 1.00 27.46 ? 25  ARG A NH2 1 
ATOM   212  N  N   . ALA A 1 26  ? 33.116 6.165   41.028 1.00 7.88  ? 26  ALA A N   1 
ATOM   213  C  CA  . ALA A 1 26  ? 31.671 6.301   41.245 1.00 8.11  ? 26  ALA A CA  1 
ATOM   214  C  C   . ALA A 1 26  ? 30.941 5.207   40.480 1.00 7.56  ? 26  ALA A C   1 
ATOM   215  O  O   . ALA A 1 26  ? 30.023 4.586   40.998 1.00 7.68  ? 26  ALA A O   1 
ATOM   216  C  CB  . ALA A 1 26  ? 31.210 7.675   40.810 1.00 8.16  ? 26  ALA A CB  1 
ATOM   217  N  N   . SER A 1 27  ? 31.361 4.965   39.260 1.00 7.13  ? 27  SER A N   1 
ATOM   218  C  CA  . SER A 1 27  ? 30.773 3.914   38.428 1.00 6.71  ? 27  SER A CA  1 
ATOM   219  C  C   . SER A 1 27  ? 30.878 2.573   39.163 1.00 7.44  ? 27  SER A C   1 
ATOM   220  O  O   . SER A 1 27  ? 29.945 1.785   39.214 1.00 7.72  ? 27  SER A O   1 
ATOM   221  C  CB  . SER A 1 27  ? 31.455 3.867   37.072 1.00 7.73  ? 27  SER A CB  1 
ATOM   222  O  OG  . SER A 1 27  ? 30.857 2.908   36.225 1.00 9.59  ? 27  SER A OG  1 
ATOM   223  N  N   . TYR A 1 28  ? 32.061 2.295   39.719 1.00 7.14  ? 28  TYR A N   1 
ATOM   224  C  CA  . TYR A 1 28  ? 32.307 1.054   40.443 1.00 6.74  ? 28  TYR A CA  1 
ATOM   225  C  C   . TYR A 1 28  ? 31.443 0.946   41.680 1.00 7.42  ? 28  TYR A C   1 
ATOM   226  O  O   . TYR A 1 28  ? 30.906 -0.131  41.968 1.00 7.55  ? 28  TYR A O   1 
ATOM   227  C  CB  . TYR A 1 28  ? 33.795 1.031   40.801 1.00 7.43  ? 28  TYR A CB  1 
ATOM   228  C  CG  . TYR A 1 28  ? 34.434 -0.282  41.173 1.00 7.25  ? 28  TYR A CG  1 
ATOM   229  C  CD1 . TYR A 1 28  ? 33.891 -1.500  40.790 1.00 8.20  ? 28  TYR A CD1 1 
ATOM   230  C  CD2 . TYR A 1 28  ? 35.610 -0.309  41.863 1.00 8.62  ? 28  TYR A CD2 1 
ATOM   231  C  CE1 . TYR A 1 28  ? 34.512 -2.706  41.088 1.00 8.28  ? 28  TYR A CE1 1 
ATOM   232  C  CE2 . TYR A 1 28  ? 36.250 -1.511  42.164 1.00 8.68  ? 28  TYR A CE2 1 
ATOM   233  C  CZ  . TYR A 1 28  ? 35.705 -2.720  41.772 1.00 7.51  ? 28  TYR A CZ  1 
ATOM   234  O  OH  . TYR A 1 28  ? 36.303 -3.933  42.063 1.00 7.83  ? 28  TYR A OH  1 
ATOM   235  N  N   . THR A 1 29  ? 31.288 2.064   42.407 1.00 7.41  ? 29  THR A N   1 
ATOM   236  C  CA  . THR A 1 29  ? 30.371 2.107   43.541 1.00 7.28  ? 29  THR A CA  1 
ATOM   237  C  C   . THR A 1 29  ? 28.960 1.726   43.103 1.00 6.65  ? 29  THR A C   1 
ATOM   238  O  O   . THR A 1 29  ? 28.299 0.930   43.770 1.00 6.97  ? 29  THR A O   1 
ATOM   239  C  CB  . THR A 1 29  ? 30.425 3.483   44.204 1.00 7.79  ? 29  THR A CB  1 
ATOM   240  O  OG1 . THR A 1 29  ? 31.758 3.665   44.743 1.00 8.23  ? 29  THR A OG1 1 
ATOM   241  C  CG2 . THR A 1 29  ? 29.391 3.614   45.302 1.00 7.90  ? 29  THR A CG2 1 
ATOM   242  N  N   . TYR A 1 30  ? 28.492 2.305   41.987 1.00 6.94  ? 30  TYR A N   1 
ATOM   243  C  CA  . TYR A 1 30  ? 27.160 1.993   41.522 1.00 6.94  ? 30  TYR A CA  1 
ATOM   244  C  C   . TYR A 1 30  ? 27.034 0.559   41.050 1.00 6.61  ? 30  TYR A C   1 
ATOM   245  O  O   . TYR A 1 30  ? 25.966 -0.044  41.240 1.00 7.36  ? 30  TYR A O   1 
ATOM   246  C  CB  . TYR A 1 30  ? 26.703 3.003   40.469 1.00 6.72  ? 30  TYR A CB  1 
ATOM   247  C  CG  . TYR A 1 30  ? 26.410 4.366   41.062 1.00 7.67  ? 30  TYR A CG  1 
ATOM   248  C  CD1 . TYR A 1 30  ? 25.555 4.504   42.139 1.00 8.68  ? 30  TYR A CD1 1 
ATOM   249  C  CD2 . TYR A 1 30  ? 26.971 5.525   40.551 1.00 7.98  ? 30  TYR A CD2 1 
ATOM   250  C  CE1 . TYR A 1 30  ? 25.286 5.740   42.712 1.00 9.95  ? 30  TYR A CE1 1 
ATOM   251  C  CE2 . TYR A 1 30  ? 26.664 6.785   41.056 1.00 8.69  ? 30  TYR A CE2 1 
ATOM   252  C  CZ  . TYR A 1 30  ? 25.828 6.889   42.144 1.00 9.26  ? 30  TYR A CZ  1 
ATOM   253  O  OH  . TYR A 1 30  ? 25.535 8.079   42.722 1.00 10.65 ? 30  TYR A OH  1 
ATOM   254  N  N   . LEU A 1 31  ? 28.077 -0.027  40.461 1.00 6.61  ? 31  LEU A N   1 
ATOM   255  C  CA  . LEU A 1 31  ? 28.041 -1.447  40.131 1.00 6.78  ? 31  LEU A CA  1 
ATOM   256  C  C   . LEU A 1 31  ? 27.801 -2.263  41.408 1.00 6.74  ? 31  LEU A C   1 
ATOM   257  O  O   . LEU A 1 31  ? 27.001 -3.202  41.416 1.00 7.49  ? 31  LEU A O   1 
ATOM   258  C  CB  . LEU A 1 31  ? 29.393 -1.825  39.529 1.00 7.81  ? 31  LEU A CB  1 
ATOM   259  C  CG  . LEU A 1 31  ? 29.534 -3.295  39.121 1.00 8.34  ? 31  LEU A CG  1 
ATOM   260  C  CD1 . LEU A 1 31  ? 28.661 -3.641  37.940 1.00 8.88  ? 31  LEU A CD1 1 
ATOM   261  C  CD2 . LEU A 1 31  ? 30.972 -3.601  38.721 1.00 8.46  ? 31  LEU A CD2 1 
ATOM   262  N  N   . SER A 1 32  ? 28.525 -1.960  42.485 1.00 6.66  ? 32  SER A N   1 
ATOM   263  C  CA  . SER A 1 32  ? 28.372 -2.667  43.733 1.00 6.73  ? 32  SER A CA  1 
ATOM   264  C  C   . SER A 1 32  ? 26.966 -2.460  44.317 1.00 7.30  ? 32  SER A C   1 
ATOM   265  O  O   . SER A 1 32  ? 26.329 -3.423  44.761 1.00 7.51  ? 32  SER A O   1 
ATOM   266  C  CB  . SER A 1 32  ? 29.444 -2.218  44.713 1.00 6.55  ? 32  SER A CB  1 
ATOM   267  O  OG  . SER A 1 32  ? 29.235 -2.858  45.958 1.00 7.32  ? 32  SER A OG  1 
ATOM   268  N  N   . LEU A 1 33  ? 26.468 -1.234  44.304 1.00 7.21  ? 33  LEU A N   1 
ATOM   269  C  CA  . LEU A 1 33  ? 25.107 -0.969  44.780 1.00 7.71  ? 33  LEU A CA  1 
ATOM   270  C  C   . LEU A 1 33  ? 24.106 -1.804  43.994 1.00 7.37  ? 33  LEU A C   1 
ATOM   271  O  O   . LEU A 1 33  ? 23.221 -2.459  44.595 1.00 7.79  ? 33  LEU A O   1 
ATOM   272  C  CB  . LEU A 1 33  ? 24.812 0.522   44.680 1.00 7.78  ? 33  LEU A CB  1 
ATOM   273  C  CG  . LEU A 1 33  ? 25.301 1.347   45.866 1.00 8.39  ? 33  LEU A CG  1 
ATOM   274  C  CD1 . LEU A 1 33  ? 25.517 2.803   45.398 1.00 8.41  ? 33  LEU A CD1 1 
ATOM   275  C  CD2 . LEU A 1 33  ? 24.301 1.286   47.006 1.00 8.05  ? 33  LEU A CD2 1 
ATOM   276  N  N   . GLY A 1 34  ? 24.233 -1.803  42.671 1.00 7.31  ? 34  GLY A N   1 
ATOM   277  C  CA  . GLY A 1 34  ? 23.292 -2.552  41.849 1.00 7.69  ? 34  GLY A CA  1 
ATOM   278  C  C   . GLY A 1 34  ? 23.284 -4.042  42.210 1.00 8.21  ? 34  GLY A C   1 
ATOM   279  O  O   . GLY A 1 34  ? 22.204 -4.646  42.359 1.00 8.89  ? 34  GLY A O   1 
ATOM   280  N  N   . PHE A 1 35  ? 24.464 -4.668  42.308 1.00 7.68  ? 35  PHE A N   1 
ATOM   281  C  CA  . PHE A 1 35  ? 24.495 -6.099  42.576 1.00 7.99  ? 35  PHE A CA  1 
ATOM   282  C  C   . PHE A 1 35  ? 24.060 -6.401  43.996 1.00 8.11  ? 35  PHE A C   1 
ATOM   283  O  O   . PHE A 1 35  ? 23.536 -7.497  44.205 1.00 9.70  ? 35  PHE A O   1 
ATOM   284  C  CB  . PHE A 1 35  ? 25.856 -6.688  42.167 1.00 8.40  ? 35  PHE A CB  1 
ATOM   285  C  CG  . PHE A 1 35  ? 25.820 -7.017  40.686 1.00 8.52  ? 35  PHE A CG  1 
ATOM   286  C  CD1 . PHE A 1 35  ? 25.114 -8.127  40.234 1.00 8.51  ? 35  PHE A CD1 1 
ATOM   287  C  CD2 . PHE A 1 35  ? 26.411 -6.173  39.755 1.00 9.37  ? 35  PHE A CD2 1 
ATOM   288  C  CE1 . PHE A 1 35  ? 25.065 -8.428  38.913 1.00 9.49  ? 35  PHE A CE1 1 
ATOM   289  C  CE2 . PHE A 1 35  ? 26.359 -6.472  38.396 1.00 10.14 ? 35  PHE A CE2 1 
ATOM   290  C  CZ  . PHE A 1 35  ? 25.607 -7.552  37.978 1.00 10.43 ? 35  PHE A CZ  1 
ATOM   291  N  N   . TYR A 1 36  ? 24.216 -5.460  44.957 1.00 7.12  ? 36  TYR A N   1 
ATOM   292  C  CA  . TYR A 1 36  ? 23.690 -5.703  46.282 1.00 7.22  ? 36  TYR A CA  1 
ATOM   293  C  C   . TYR A 1 36  ? 22.164 -5.842  46.210 1.00 7.37  ? 36  TYR A C   1 
ATOM   294  O  O   . TYR A 1 36  ? 21.629 -6.742  46.853 1.00 7.99  ? 36  TYR A O   1 
ATOM   295  C  CB  . TYR A 1 36  ? 24.173 -4.575  47.201 1.00 7.28  ? 36  TYR A CB  1 
ATOM   296  C  CG  . TYR A 1 36  ? 23.507 -4.522  48.559 1.00 7.58  ? 36  TYR A CG  1 
ATOM   297  C  CD1 . TYR A 1 36  ? 23.874 -5.368  49.564 1.00 8.23  ? 36  TYR A CD1 1 
ATOM   298  C  CD2 . TYR A 1 36  ? 22.418 -3.687  48.767 1.00 7.58  ? 36  TYR A CD2 1 
ATOM   299  C  CE1 . TYR A 1 36  ? 23.222 -5.368  50.783 1.00 8.27  ? 36  TYR A CE1 1 
ATOM   300  C  CE2 . TYR A 1 36  ? 21.791 -3.630  50.004 1.00 8.38  ? 36  TYR A CE2 1 
ATOM   301  C  CZ  . TYR A 1 36  ? 22.183 -4.479  51.016 1.00 8.40  ? 36  TYR A CZ  1 
ATOM   302  O  OH  . TYR A 1 36  ? 21.515 -4.419  52.220 1.00 9.62  ? 36  TYR A OH  1 
ATOM   303  N  N   . PHE A 1 37  ? 21.515 -4.927  45.497 1.00 7.24  ? 37  PHE A N   1 
ATOM   304  C  CA  . PHE A 1 37  ? 20.052 -4.950  45.454 1.00 7.55  ? 37  PHE A CA  1 
ATOM   305  C  C   . PHE A 1 37  ? 19.534 -6.110  44.614 1.00 8.02  ? 37  PHE A C   1 
ATOM   306  O  O   . PHE A 1 37  ? 18.328 -6.435  44.688 1.00 8.22  ? 37  PHE A O   1 
ATOM   307  C  CB  . PHE A 1 37  ? 19.518 -3.572  45.048 1.00 7.62  ? 37  PHE A CB  1 
ATOM   308  C  CG  . PHE A 1 37  ? 19.582 -2.607  46.202 1.00 7.58  ? 37  PHE A CG  1 
ATOM   309  C  CD1 . PHE A 1 37  ? 18.619 -2.607  47.191 1.00 7.14  ? 37  PHE A CD1 1 
ATOM   310  C  CD2 . PHE A 1 37  ? 20.606 -1.686  46.307 1.00 7.01  ? 37  PHE A CD2 1 
ATOM   311  C  CE1 . PHE A 1 37  ? 18.695 -1.776  48.263 1.00 7.56  ? 37  PHE A CE1 1 
ATOM   312  C  CE2 . PHE A 1 37  ? 20.698 -0.849  47.393 1.00 7.05  ? 37  PHE A CE2 1 
ATOM   313  C  CZ  . PHE A 1 37  ? 19.720 -0.859  48.367 1.00 6.74  ? 37  PHE A CZ  1 
ATOM   314  N  N   . ASP A 1 38  ? 20.370 -6.774  43.809 1.00 7.49  ? 38  ASP A N   1 
ATOM   315  C  CA  . ASP A 1 38  ? 20.060 -7.974  43.052 1.00 8.06  ? 38  ASP A CA  1 
ATOM   316  C  C   . ASP A 1 38  ? 20.160 -9.251  43.895 1.00 8.41  ? 38  ASP A C   1 
ATOM   317  O  O   . ASP A 1 38  ? 19.780 -10.318 43.414 1.00 10.59 ? 38  ASP A O   1 
ATOM   318  C  CB  . ASP A 1 38  ? 20.979 -8.031  41.843 1.00 8.79  ? 38  ASP A CB  1 
ATOM   319  C  CG  . ASP A 1 38  ? 20.767 -9.208  40.927 1.00 9.87  ? 38  ASP A CG  1 
ATOM   320  O  OD1 . ASP A 1 38  ? 19.691 -9.239  40.293 1.00 13.21 ? 38  ASP A OD1 1 
ATOM   321  O  OD2 . ASP A 1 38  ? 21.647 -10.042 40.827 1.00 10.75 ? 38  ASP A OD2 1 
ATOM   322  N  N   . ARG A 1 39  ? 20.720 -9.196  45.096 1.00 7.19  ? 39  ARG A N   1 
ATOM   323  C  CA  . ARG A 1 39  ? 20.873 -10.368 45.944 1.00 8.00  ? 39  ARG A CA  1 
ATOM   324  C  C   . ARG A 1 39  ? 19.482 -10.968 46.203 1.00 8.14  ? 39  ARG A C   1 
ATOM   325  O  O   . ARG A 1 39  ? 18.514 -10.228 46.440 1.00 7.53  ? 39  ARG A O   1 
ATOM   326  C  CB  . ARG A 1 39  ? 21.515 -10.004 47.280 1.00 7.97  ? 39  ARG A CB  1 
ATOM   327  C  CG  . ARG A 1 39  ? 23.013 -9.734  47.201 1.00 8.98  ? 39  ARG A CG  1 
ATOM   328  C  CD  . ARG A 1 39  ? 23.598 -9.338  48.511 1.00 10.29 ? 39  ARG A CD  1 
ATOM   329  N  NE  . ARG A 1 39  ? 23.325 -10.386 49.515 1.00 13.08 ? 39  ARG A NE  1 
ATOM   330  C  CZ  . ARG A 1 39  ? 24.009 -11.615 49.470 1.00 19.13 ? 39  ARG A CZ  1 
ATOM   331  N  NH1 . ARG A 1 39  ? 25.158 -11.824 48.804 1.00 18.94 ? 39  ARG A NH1 1 
ATOM   332  N  NH2 . ARG A 1 39  ? 23.638 -12.666 50.161 1.00 18.74 ? 39  ARG A NH2 1 
ATOM   333  N  N   . ASP A 1 40  ? 19.428 -12.313 46.339 1.00 7.70  ? 40  ASP A N   1 
ATOM   334  C  CA  . ASP A 1 40  ? 18.155 -12.965 46.658 1.00 8.13  ? 40  ASP A CA  1 
ATOM   335  C  C   . ASP A 1 40  ? 17.596 -12.538 48.014 1.00 7.80  ? 40  ASP A C   1 
ATOM   336  O  O   . ASP A 1 40  ? 16.367 -12.604 48.194 1.00 8.57  ? 40  ASP A O   1 
ATOM   337  C  CB  . ASP A 1 40  ? 18.242 -14.484 46.594 1.00 8.66  ? 40  ASP A CB  1 
ATOM   338  C  CG  . ASP A 1 40  ? 18.991 -15.094 47.753 1.00 9.61  ? 40  ASP A CG  1 
ATOM   339  O  OD1 . ASP A 1 40  ? 20.245 -15.169 47.714 1.00 10.63 ? 40  ASP A OD1 1 
ATOM   340  O  OD2 . ASP A 1 40  ? 18.321 -15.444 48.773 1.00 10.64 ? 40  ASP A OD2 1 
ATOM   341  N  N   . ASP A 1 41  ? 18.425 -12.089 48.945 1.00 7.22  ? 41  ASP A N   1 
ATOM   342  C  CA  . ASP A 1 41  ? 18.038 -11.668 50.289 1.00 8.41  ? 41  ASP A CA  1 
ATOM   343  C  C   . ASP A 1 41  ? 17.858 -10.161 50.412 1.00 7.24  ? 41  ASP A C   1 
ATOM   344  O  O   . ASP A 1 41  ? 17.677 -9.670  51.538 1.00 8.47  ? 41  ASP A O   1 
ATOM   345  C  CB  . ASP A 1 41  ? 18.972 -12.234 51.332 1.00 8.89  ? 41  ASP A CB  1 
ATOM   346  C  CG  . ASP A 1 41  ? 20.401 -11.735 51.261 1.00 9.67  ? 41  ASP A CG  1 
ATOM   347  O  OD1 . ASP A 1 41  ? 20.682 -10.988 50.330 1.00 10.85 ? 41  ASP A OD1 1 
ATOM   348  O  OD2 . ASP A 1 41  ? 21.208 -12.141 52.149 1.00 11.36 ? 41  ASP A OD2 1 
ATOM   349  N  N   . VAL A 1 42  ? 17.890 -9.451  49.283 1.00 7.89  ? 42  VAL A N   1 
ATOM   350  C  CA  . VAL A 1 42  ? 17.573 -8.025  49.204 1.00 8.27  ? 42  VAL A CA  1 
ATOM   351  C  C   . VAL A 1 42  ? 16.442 -7.830  48.199 1.00 8.32  ? 42  VAL A C   1 
ATOM   352  O  O   . VAL A 1 42  ? 15.345 -7.404  48.586 1.00 9.11  ? 42  VAL A O   1 
ATOM   353  C  CB  . VAL A 1 42  ? 18.827 -7.182  48.877 1.00 8.62  ? 42  VAL A CB  1 
ATOM   354  C  CG1 . VAL A 1 42  ? 18.454 -5.702  48.738 1.00 9.51  ? 42  VAL A CG1 1 
ATOM   355  C  CG2 . VAL A 1 42  ? 19.960 -7.394  49.873 1.00 9.28  ? 42  VAL A CG2 1 
ATOM   356  N  N   . ALA A 1 43  ? 16.692 -8.181  46.926 1.00 7.24  ? 43  ALA A N   1 
ATOM   357  C  CA  . ALA A 1 43  ? 15.646 -8.463  45.942 1.00 7.54  ? 43  ALA A CA  1 
ATOM   358  C  C   . ALA A 1 43  ? 14.777 -7.235  45.717 1.00 7.97  ? 43  ALA A C   1 
ATOM   359  O  O   . ALA A 1 43  ? 13.553 -7.292  45.855 1.00 8.85  ? 43  ALA A O   1 
ATOM   360  C  CB  . ALA A 1 43  ? 14.812 -9.686  46.305 1.00 8.66  ? 43  ALA A CB  1 
ATOM   361  N  N   . LEU A 1 44  ? 15.377 -6.119  45.321 1.00 7.84  ? 44  LEU A N   1 
ATOM   362  C  CA  . LEU A 1 44  ? 14.639 -4.903  44.997 1.00 7.66  ? 44  LEU A CA  1 
ATOM   363  C  C   . LEU A 1 44  ? 15.050 -4.500  43.592 1.00 7.96  ? 44  LEU A C   1 
ATOM   364  O  O   . LEU A 1 44  ? 15.948 -3.661  43.403 1.00 8.20  ? 44  LEU A O   1 
ATOM   365  C  CB  . LEU A 1 44  ? 14.905 -3.830  46.038 1.00 7.49  ? 44  LEU A CB  1 
ATOM   366  C  CG  . LEU A 1 44  ? 14.311 -4.106  47.415 1.00 7.65  ? 44  LEU A CG  1 
ATOM   367  C  CD1 . LEU A 1 44  ? 14.900 -3.228  48.509 1.00 7.75  ? 44  LEU A CD1 1 
ATOM   368  C  CD2 . LEU A 1 44  ? 12.789 -3.961  47.381 1.00 8.75  ? 44  LEU A CD2 1 
ATOM   369  N  N   . GLU A 1 45  ? 14.376 -5.058  42.600 1.00 7.85  ? 45  GLU A N   1 
ATOM   370  C  CA  . GLU A 1 45  ? 14.791 -4.953  41.211 1.00 9.71  ? 45  GLU A CA  1 
ATOM   371  C  C   . GLU A 1 45  ? 14.867 -3.499  40.734 1.00 8.91  ? 45  GLU A C   1 
ATOM   372  O  O   . GLU A 1 45  ? 15.779 -3.071  40.021 1.00 9.05  ? 45  GLU A O   1 
ATOM   373  C  CB  . GLU A 1 45  ? 13.892 -5.755  40.268 1.00 12.81 ? 45  GLU A CB  1 
ATOM   374  C  CG  . GLU A 1 45  ? 14.200 -5.710  38.773 1.00 18.68 ? 45  GLU A CG  1 
ATOM   375  C  CD  . GLU A 1 45  ? 13.110 -6.414  37.938 1.00 28.27 ? 45  GLU A CD  1 
ATOM   376  O  OE1 . GLU A 1 45  ? 12.715 -7.557  38.280 1.00 30.84 ? 45  GLU A OE1 1 
ATOM   377  O  OE2 . GLU A 1 45  ? 12.597 -5.792  36.978 1.00 38.79 ? 45  GLU A OE2 1 
ATOM   378  N  N   . GLY A 1 46  ? 13.889 -2.686  41.109 1.00 7.99  ? 46  GLY A N   1 
ATOM   379  C  CA  . GLY A 1 46  ? 13.908 -1.297  40.662 1.00 7.57  ? 46  GLY A CA  1 
ATOM   380  C  C   . GLY A 1 46  ? 15.113 -0.529  41.232 1.00 7.50  ? 46  GLY A C   1 
ATOM   381  O  O   . GLY A 1 46  ? 15.609 0.397   40.561 1.00 8.76  ? 46  GLY A O   1 
ATOM   382  N  N   . VAL A 1 47  ? 15.544 -0.922  42.427 1.00 7.13  ? 47  VAL A N   1 
ATOM   383  C  CA  . VAL A 1 47  ? 16.712 -0.285  43.043 1.00 7.43  ? 47  VAL A CA  1 
ATOM   384  C  C   . VAL A 1 47  ? 17.976 -0.745  42.298 1.00 8.81  ? 47  VAL A C   1 
ATOM   385  O  O   . VAL A 1 47  ? 18.853 0.079   41.970 1.00 7.63  ? 47  VAL A O   1 
ATOM   386  C  CB  . VAL A 1 47  ? 16.791 -0.509  44.558 1.00 8.00  ? 47  VAL A CB  1 
ATOM   387  C  CG1 . VAL A 1 47  ? 17.906 0.320   45.153 1.00 8.58  ? 47  VAL A CG1 1 
ATOM   388  C  CG2 . VAL A 1 47  ? 15.461 -0.132  45.239 1.00 8.34  ? 47  VAL A CG2 1 
ATOM   389  N  N   . CYS A 1 48  ? 18.086 -2.043  42.050 1.00 8.13  ? 48  CYS A N   1 
ATOM   390  C  CA  . CYS A 1 48  ? 19.162 -2.605  41.236 1.00 9.21  ? 48  CYS A CA  1 
ATOM   391  C  C   . CYS A 1 48  ? 19.252 -1.854  39.911 1.00 9.52  ? 48  CYS A C   1 
ATOM   392  O  O   . CYS A 1 48  ? 20.331 -1.407  39.489 1.00 9.89  ? 48  CYS A O   1 
ATOM   393  C  CB  . CYS A 1 48  ? 18.891 -4.090  41.075 1.00 10.91 ? 48  CYS A CB  1 
ATOM   394  S  SG  . CYS A 1 48  ? 19.931 -4.845  39.816 1.00 14.15 ? 48  CYS A SG  1 
ATOM   395  N  N   . HIS A 1 49  ? 18.129 -1.704  39.214 1.00 8.88  ? 49  HIS A N   1 
ATOM   396  C  CA  . HIS A 1 49  ? 18.144 -1.054  37.921 1.00 9.83  ? 49  HIS A CA  1 
ATOM   397  C  C   . HIS A 1 49  ? 18.534 0.423   38.001 1.00 9.08  ? 49  HIS A C   1 
ATOM   398  O  O   . HIS A 1 49  ? 19.298 0.885   37.146 1.00 9.40  ? 49  HIS A O   1 
ATOM   399  C  CB  . HIS A 1 49  ? 16.774 -1.180  37.254 1.00 12.77 ? 49  HIS A CB  1 
ATOM   400  C  CG  . HIS A 1 49  ? 16.536 -2.560  36.717 1.00 21.20 ? 49  HIS A CG  1 
ATOM   401  N  ND1 . HIS A 1 49  ? 15.505 -2.886  35.849 1.00 31.86 ? 49  HIS A ND1 1 
ATOM   402  C  CD2 . HIS A 1 49  ? 17.190 -3.713  36.960 1.00 26.70 ? 49  HIS A CD2 1 
ATOM   403  C  CE1 . HIS A 1 49  ? 15.542 -4.189  35.584 1.00 28.02 ? 49  HIS A CE1 1 
ATOM   404  N  NE2 . HIS A 1 49  ? 16.560 -4.714  36.250 1.00 30.04 ? 49  HIS A NE2 1 
ATOM   405  N  N   . PHE A 1 50  ? 18.104 1.126   39.044 1.00 8.37  ? 50  PHE A N   1 
ATOM   406  C  CA  . PHE A 1 50  ? 18.461 2.529   39.221 1.00 8.43  ? 50  PHE A CA  1 
ATOM   407  C  C   . PHE A 1 50  ? 19.991 2.637   39.305 1.00 8.09  ? 50  PHE A C   1 
ATOM   408  O  O   . PHE A 1 50  ? 20.596 3.479   38.631 1.00 9.08  ? 50  PHE A O   1 
ATOM   409  C  CB  . PHE A 1 50  ? 17.793 3.064   40.488 1.00 8.42  ? 50  PHE A CB  1 
ATOM   410  C  CG  . PHE A 1 50  ? 18.094 4.516   40.808 1.00 9.59  ? 50  PHE A CG  1 
ATOM   411  C  CD1 . PHE A 1 50  ? 17.498 5.560   40.111 1.00 11.24 ? 50  PHE A CD1 1 
ATOM   412  C  CD2 . PHE A 1 50  ? 18.937 4.818   41.849 1.00 9.56  ? 50  PHE A CD2 1 
ATOM   413  C  CE1 . PHE A 1 50  ? 17.811 6.882   40.420 1.00 11.87 ? 50  PHE A CE1 1 
ATOM   414  C  CE2 . PHE A 1 50  ? 19.229 6.133   42.168 1.00 11.01 ? 50  PHE A CE2 1 
ATOM   415  C  CZ  . PHE A 1 50  ? 18.672 7.150   41.434 1.00 11.01 ? 50  PHE A CZ  1 
ATOM   416  N  N   . PHE A 1 51  ? 20.594 1.861   40.179 1.00 7.87  ? 51  PHE A N   1 
ATOM   417  C  CA  . PHE A 1 51  ? 22.038 2.006   40.369 1.00 8.25  ? 51  PHE A CA  1 
ATOM   418  C  C   . PHE A 1 51  ? 22.825 1.452   39.199 1.00 9.07  ? 51  PHE A C   1 
ATOM   419  O  O   . PHE A 1 51  ? 23.885 2.014   38.864 1.00 8.93  ? 51  PHE A O   1 
ATOM   420  C  CB  . PHE A 1 51  ? 22.442 1.388   41.713 1.00 7.71  ? 51  PHE A CB  1 
ATOM   421  C  CG  . PHE A 1 51  ? 21.960 2.164   42.913 1.00 7.82  ? 51  PHE A CG  1 
ATOM   422  C  CD1 . PHE A 1 51  ? 22.249 3.514   43.028 1.00 9.37  ? 51  PHE A CD1 1 
ATOM   423  C  CD2 . PHE A 1 51  ? 21.245 1.569   43.944 1.00 8.05  ? 51  PHE A CD2 1 
ATOM   424  C  CE1 . PHE A 1 51  ? 21.822 4.227   44.121 1.00 9.56  ? 51  PHE A CE1 1 
ATOM   425  C  CE2 . PHE A 1 51  ? 20.806 2.287   45.046 1.00 8.84  ? 51  PHE A CE2 1 
ATOM   426  C  CZ  . PHE A 1 51  ? 21.091 3.626   45.123 1.00 9.58  ? 51  PHE A CZ  1 
ATOM   427  N  N   . ARG A 1 52  ? 22.361 0.403   38.525 1.00 10.06 ? 52  ARG A N   1 
ATOM   428  C  CA  A ARG A 1 52  ? 23.068 -0.078  37.343 0.51 11.73 ? 52  ARG A CA  1 
ATOM   429  C  CA  B ARG A 1 52  ? 23.053 -0.087  37.339 0.49 11.99 ? 52  ARG A CA  1 
ATOM   430  C  C   . ARG A 1 52  ? 23.085 0.995   36.258 1.00 10.78 ? 52  ARG A C   1 
ATOM   431  O  O   . ARG A 1 52  ? 24.132 1.206   35.602 1.00 11.27 ? 52  ARG A O   1 
ATOM   432  C  CB  A ARG A 1 52  ? 22.460 -1.370  36.798 0.51 14.04 ? 52  ARG A CB  1 
ATOM   433  C  CB  B ARG A 1 52  ? 22.375 -1.374  36.864 0.49 14.71 ? 52  ARG A CB  1 
ATOM   434  C  CG  A ARG A 1 52  ? 22.867 -2.595  37.599 0.51 16.74 ? 52  ARG A CG  1 
ATOM   435  C  CG  B ARG A 1 52  ? 22.947 -1.932  35.571 0.49 18.56 ? 52  ARG A CG  1 
ATOM   436  C  CD  A ARG A 1 52  ? 22.348 -3.909  36.993 0.51 20.33 ? 52  ARG A CD  1 
ATOM   437  C  CD  B ARG A 1 52  ? 22.228 -3.225  35.147 0.49 21.36 ? 52  ARG A CD  1 
ATOM   438  N  NE  A ARG A 1 52  ? 20.985 -3.674  36.510 0.51 24.81 ? 52  ARG A NE  1 
ATOM   439  N  NE  B ARG A 1 52  ? 20.975 -2.997  34.421 0.49 24.57 ? 52  ARG A NE  1 
ATOM   440  C  CZ  A ARG A 1 52  ? 20.459 -4.042  35.349 0.51 31.06 ? 52  ARG A CZ  1 
ATOM   441  C  CZ  B ARG A 1 52  ? 19.902 -3.778  34.487 0.49 30.11 ? 52  ARG A CZ  1 
ATOM   442  N  NH1 A ARG A 1 52  ? 20.869 -5.137  34.730 0.51 34.44 ? 52  ARG A NH1 1 
ATOM   443  N  NH1 B ARG A 1 52  ? 19.886 -4.849  35.265 0.49 31.97 ? 52  ARG A NH1 1 
ATOM   444  N  NH2 A ARG A 1 52  ? 19.599 -3.237  34.750 0.51 35.66 ? 52  ARG A NH2 1 
ATOM   445  N  NH2 B ARG A 1 52  ? 18.831 -3.477  33.774 0.49 32.34 ? 52  ARG A NH2 1 
ATOM   446  N  N   . PHE A 1 53  ? 21.967 1.727   36.074 1.00 11.43 ? 53  PHE A N   1 
ATOM   447  C  CA  . PHE A 1 53  ? 21.917 2.815   35.111 1.00 12.95 ? 53  PHE A CA  1 
ATOM   448  C  C   . PHE A 1 53  ? 22.926 3.898   35.491 1.00 12.36 ? 53  PHE A C   1 
ATOM   449  O  O   . PHE A 1 53  ? 23.668 4.394   34.631 1.00 11.76 ? 53  PHE A O   1 
ATOM   450  C  CB  . PHE A 1 53  ? 20.506 3.417   35.087 1.00 15.93 ? 53  PHE A CB  1 
ATOM   451  C  CG  . PHE A 1 53  ? 20.526 4.707   34.279 1.00 23.22 ? 53  PHE A CG  1 
ATOM   452  C  CD1 . PHE A 1 53  ? 20.572 4.654   32.890 1.00 34.02 ? 53  PHE A CD1 1 
ATOM   453  C  CD2 . PHE A 1 53  ? 20.570 5.949   34.891 1.00 28.72 ? 53  PHE A CD2 1 
ATOM   454  C  CE1 . PHE A 1 53  ? 20.636 5.821   32.139 1.00 37.15 ? 53  PHE A CE1 1 
ATOM   455  C  CE2 . PHE A 1 53  ? 20.643 7.122   34.130 1.00 34.07 ? 53  PHE A CE2 1 
ATOM   456  C  CZ  . PHE A 1 53  ? 20.671 7.047   32.761 1.00 35.75 ? 53  PHE A CZ  1 
ATOM   457  N  N   . LEU A 1 54  ? 23.024 4.206   36.786 1.00 10.06 ? 54  LEU A N   1 
ATOM   458  C  CA  . LEU A 1 54  ? 23.986 5.224   37.206 1.00 9.93  ? 54  LEU A CA  1 
ATOM   459  C  C   . LEU A 1 54  ? 25.406 4.743   36.968 1.00 9.52  ? 54  LEU A C   1 
ATOM   460  O  O   . LEU A 1 54  ? 26.299 5.552   36.662 1.00 9.77  ? 54  LEU A O   1 
ATOM   461  C  CB  . LEU A 1 54  ? 23.755 5.615   38.651 1.00 10.02 ? 54  LEU A CB  1 
ATOM   462  C  CG  . LEU A 1 54  ? 22.469 6.388   38.906 1.00 12.03 ? 54  LEU A CG  1 
ATOM   463  C  CD1 . LEU A 1 54  ? 22.329 6.719   40.349 1.00 12.92 ? 54  LEU A CD1 1 
ATOM   464  C  CD2 . LEU A 1 54  ? 22.384 7.620   38.011 1.00 15.60 ? 54  LEU A CD2 1 
ATOM   465  N  N   . ALA A 1 55  ? 25.689 3.449   37.142 1.00 8.85  ? 55  ALA A N   1 
ATOM   466  C  CA  . ALA A 1 55  ? 27.024 2.944   36.873 1.00 8.94  ? 55  ALA A CA  1 
ATOM   467  C  C   . ALA A 1 55  ? 27.399 3.258   35.418 1.00 9.75  ? 55  ALA A C   1 
ATOM   468  O  O   . ALA A 1 55  ? 28.499 3.743   35.119 1.00 10.46 ? 55  ALA A O   1 
ATOM   469  C  CB  . ALA A 1 55  ? 27.099 1.447   37.140 1.00 9.14  ? 55  ALA A CB  1 
ATOM   470  N  N   . PHE A 1 56  ? 26.460 3.033   34.496 1.00 9.93  ? 56  PHE A N   1 
ATOM   471  C  CA  . PHE A 1 56  ? 26.742 3.262   33.093 1.00 11.68 ? 56  PHE A CA  1 
ATOM   472  C  C   . PHE A 1 56  ? 26.874 4.764   32.849 1.00 10.93 ? 56  PHE A C   1 
ATOM   473  O  O   . PHE A 1 56  ? 27.745 5.205   32.072 1.00 10.60 ? 56  PHE A O   1 
ATOM   474  C  CB  . PHE A 1 56  ? 25.634 2.663   32.242 1.00 15.48 ? 56  PHE A CB  1 
ATOM   475  C  CG  . PHE A 1 56  ? 25.931 1.199   32.015 1.00 23.66 ? 56  PHE A CG  1 
ATOM   476  C  CD1 . PHE A 1 56  ? 26.946 0.828   31.130 1.00 31.63 ? 56  PHE A CD1 1 
ATOM   477  C  CD2 . PHE A 1 56  ? 25.204 0.202   32.667 1.00 33.92 ? 56  PHE A CD2 1 
ATOM   478  C  CE1 . PHE A 1 56  ? 27.228 -0.520  30.915 1.00 36.39 ? 56  PHE A CE1 1 
ATOM   479  C  CE2 . PHE A 1 56  ? 25.488 -1.143  32.461 1.00 34.83 ? 56  PHE A CE2 1 
ATOM   480  C  CZ  . PHE A 1 56  ? 26.498 -1.500  31.578 1.00 39.28 ? 56  PHE A CZ  1 
ATOM   481  N  N   . PHE A 1 57  ? 26.005 5.548   33.476 1.00 11.58 ? 57  PHE A N   1 
ATOM   482  C  CA  . PHE A 1 57  ? 26.052 6.982   33.296 1.00 11.78 ? 57  PHE A CA  1 
ATOM   483  C  C   . PHE A 1 57  ? 27.398 7.564   33.727 1.00 10.50 ? 57  PHE A C   1 
ATOM   484  O  O   . PHE A 1 57  ? 27.974 8.465   33.081 1.00 9.74  ? 57  PHE A O   1 
ATOM   485  C  CB  . PHE A 1 57  ? 24.874 7.562   34.072 1.00 13.62 ? 57  PHE A CB  1 
ATOM   486  C  CG  . PHE A 1 57  ? 24.519 8.997   33.759 1.00 20.43 ? 57  PHE A CG  1 
ATOM   487  C  CD1 . PHE A 1 57  ? 24.627 9.493   32.469 1.00 26.13 ? 57  PHE A CD1 1 
ATOM   488  C  CD2 . PHE A 1 57  ? 24.117 9.856   34.771 1.00 23.61 ? 57  PHE A CD2 1 
ATOM   489  C  CE1 . PHE A 1 57  ? 24.282 10.810  32.190 1.00 28.61 ? 57  PHE A CE1 1 
ATOM   490  C  CE2 . PHE A 1 57  ? 23.767 11.163  34.486 1.00 26.00 ? 57  PHE A CE2 1 
ATOM   491  C  CZ  . PHE A 1 57  ? 23.846 11.629  33.206 1.00 26.33 ? 57  PHE A CZ  1 
ATOM   492  N  N   . LYS A 1 58  ? 27.931 7.128   34.866 1.00 9.62  ? 58  LYS A N   1 
ATOM   493  C  CA  . LYS A 1 58  ? 29.224 7.615   35.316 1.00 8.86  ? 58  LYS A CA  1 
ATOM   494  C  C   . LYS A 1 58  ? 30.358 7.128   34.411 1.00 8.85  ? 58  LYS A C   1 
ATOM   495  O  O   . LYS A 1 58  ? 31.309 7.889   34.154 1.00 9.18  ? 58  LYS A O   1 
ATOM   496  C  CB  . LYS A 1 58  ? 29.449 7.181   36.766 1.00 8.78  ? 58  LYS A CB  1 
ATOM   497  C  CG  . LYS A 1 58  ? 28.529 7.848   37.757 1.00 9.84  ? 58  LYS A CG  1 
ATOM   498  C  CD  . LYS A 1 58  ? 28.577 9.381   37.685 1.00 13.23 ? 58  LYS A CD  1 
ATOM   499  C  CE  . LYS A 1 58  ? 27.538 9.969   38.518 1.00 15.45 ? 58  LYS A CE  1 
ATOM   500  N  NZ  . LYS A 1 58  ? 27.518 11.438  38.421 1.00 15.26 ? 58  LYS A NZ  1 
ATOM   501  N  N   . LEU A 1 59  ? 30.303 5.893   33.926 1.00 8.96  ? 59  LEU A N   1 
ATOM   502  C  CA  . LEU A 1 59  ? 31.283 5.419   32.963 1.00 9.06  ? 59  LEU A CA  1 
ATOM   503  C  C   . LEU A 1 59  ? 31.278 6.317   31.733 1.00 9.41  ? 59  LEU A C   1 
ATOM   504  O  O   . LEU A 1 59  ? 32.330 6.685   31.217 1.00 9.53  ? 59  LEU A O   1 
ATOM   505  C  CB  . LEU A 1 59  ? 30.921 4.000   32.582 1.00 9.78  ? 59  LEU A CB  1 
ATOM   506  C  CG  . LEU A 1 59  ? 31.842 3.341   31.572 1.00 11.58 ? 59  LEU A CG  1 
ATOM   507  C  CD1 . LEU A 1 59  ? 33.286 3.282   32.035 1.00 13.23 ? 59  LEU A CD1 1 
ATOM   508  C  CD2 . LEU A 1 59  ? 31.314 1.941   31.306 1.00 12.66 ? 59  LEU A CD2 1 
ATOM   509  N  N   . PHE A 1 60  ? 30.090 6.694   31.245 1.00 9.77  ? 60  PHE A N   1 
ATOM   510  C  CA  . PHE A 1 60  ? 30.002 7.581   30.092 1.00 10.25 ? 60  PHE A CA  1 
ATOM   511  C  C   . PHE A 1 60  ? 30.623 8.951   30.370 1.00 9.32  ? 60  PHE A C   1 
ATOM   512  O  O   . PHE A 1 60  ? 31.306 9.510   29.496 1.00 9.58  ? 60  PHE A O   1 
ATOM   513  C  CB  . PHE A 1 60  ? 28.531 7.672   29.672 1.00 14.24 ? 60  PHE A CB  1 
ATOM   514  C  CG  . PHE A 1 60  ? 28.185 8.732   28.646 1.00 22.06 ? 60  PHE A CG  1 
ATOM   515  C  CD1 . PHE A 1 60  ? 28.501 8.524   27.308 1.00 27.32 ? 60  PHE A CD1 1 
ATOM   516  C  CD2 . PHE A 1 60  ? 27.512 9.902   29.007 1.00 28.96 ? 60  PHE A CD2 1 
ATOM   517  C  CE1 . PHE A 1 60  ? 28.159 9.480   26.345 1.00 29.28 ? 60  PHE A CE1 1 
ATOM   518  C  CE2 . PHE A 1 60  ? 27.169 10.842  28.043 1.00 30.32 ? 60  PHE A CE2 1 
ATOM   519  C  CZ  . PHE A 1 60  ? 27.501 10.628  26.720 1.00 29.94 ? 60  PHE A CZ  1 
ATOM   520  N  N   . GLY A 1 61  ? 30.454 9.477   31.576 1.00 8.68  ? 61  GLY A N   1 
ATOM   521  C  CA  . GLY A 1 61  ? 31.096 10.713  31.968 1.00 8.51  ? 61  GLY A CA  1 
ATOM   522  C  C   . GLY A 1 61  ? 32.614 10.593  31.902 1.00 8.80  ? 61  GLY A C   1 
ATOM   523  O  O   . GLY A 1 61  ? 33.306 11.488  31.418 1.00 8.51  ? 61  GLY A O   1 
ATOM   524  N  N   . ALA A 1 62  ? 33.164 9.494   32.446 1.00 8.38  ? 62  ALA A N   1 
ATOM   525  C  CA  . ALA A 1 62  ? 34.594 9.243   32.334 1.00 8.42  ? 62  ALA A CA  1 
ATOM   526  C  C   . ALA A 1 62  ? 35.051 9.202   30.875 1.00 8.08  ? 62  ALA A C   1 
ATOM   527  O  O   . ALA A 1 62  ? 36.091 9.757   30.534 1.00 8.37  ? 62  ALA A O   1 
ATOM   528  C  CB  . ALA A 1 62  ? 34.966 7.961   33.037 1.00 8.85  ? 62  ALA A CB  1 
ATOM   529  N  N   . PHE A 1 63  ? 34.323 8.504   29.991 1.00 8.86  ? 63  PHE A N   1 
ATOM   530  C  CA  A PHE A 1 63  ? 34.645 8.441   28.585 0.54 9.51  ? 63  PHE A CA  1 
ATOM   531  C  CA  B PHE A 1 63  ? 34.648 8.440   28.580 0.46 9.25  ? 63  PHE A CA  1 
ATOM   532  C  C   . PHE A 1 63  ? 34.692 9.849   27.981 1.00 9.05  ? 63  PHE A C   1 
ATOM   533  O  O   . PHE A 1 63  ? 35.597 10.166  27.209 1.00 9.45  ? 63  PHE A O   1 
ATOM   534  C  CB  A PHE A 1 63  ? 33.602 7.548   27.904 0.54 11.01 ? 63  PHE A CB  1 
ATOM   535  C  CB  B PHE A 1 63  ? 33.660 7.582   27.776 0.46 10.14 ? 63  PHE A CB  1 
ATOM   536  C  CG  A PHE A 1 63  ? 33.915 7.216   26.460 0.54 14.53 ? 63  PHE A CG  1 
ATOM   537  C  CG  B PHE A 1 63  ? 34.049 6.122   27.602 0.46 12.93 ? 63  PHE A CG  1 
ATOM   538  C  CD1 A PHE A 1 63  ? 33.516 8.050   25.438 0.54 17.92 ? 63  PHE A CD1 1 
ATOM   539  C  CD1 B PHE A 1 63  ? 33.916 5.201   28.632 0.46 13.63 ? 63  PHE A CD1 1 
ATOM   540  C  CD2 A PHE A 1 63  ? 34.617 6.063   26.145 0.54 17.68 ? 63  PHE A CD2 1 
ATOM   541  C  CD2 B PHE A 1 63  ? 34.592 5.679   26.397 0.46 14.73 ? 63  PHE A CD2 1 
ATOM   542  C  CE1 A PHE A 1 63  ? 33.827 7.744   24.116 0.54 18.58 ? 63  PHE A CE1 1 
ATOM   543  C  CE1 B PHE A 1 63  ? 34.262 3.865   28.446 0.46 15.47 ? 63  PHE A CE1 1 
ATOM   544  C  CE2 A PHE A 1 63  ? 34.914 5.760   24.827 0.54 18.07 ? 63  PHE A CE2 1 
ATOM   545  C  CE2 B PHE A 1 63  ? 34.958 4.348   26.211 0.46 16.06 ? 63  PHE A CE2 1 
ATOM   546  C  CZ  A PHE A 1 63  ? 34.511 6.594   23.825 0.54 18.67 ? 63  PHE A CZ  1 
ATOM   547  C  CZ  B PHE A 1 63  ? 34.792 3.444   27.238 0.46 14.92 ? 63  PHE A CZ  1 
ATOM   548  N  N   . ARG A 1 64  ? 33.716 10.681  28.298 1.00 8.92  ? 64  ARG A N   1 
ATOM   549  C  CA  . ARG A 1 64  ? 33.690 12.032  27.737 1.00 9.63  ? 64  ARG A CA  1 
ATOM   550  C  C   . ARG A 1 64  ? 34.901 12.848  28.180 1.00 8.38  ? 64  ARG A C   1 
ATOM   551  O  O   . ARG A 1 64  ? 35.512 13.598  27.388 1.00 8.83  ? 64  ARG A O   1 
ATOM   552  C  CB  . ARG A 1 64  ? 32.407 12.788  28.076 1.00 11.99 ? 64  ARG A CB  1 
ATOM   553  C  CG  . ARG A 1 64  ? 31.137 12.360  27.377 1.00 20.66 ? 64  ARG A CG  1 
ATOM   554  C  CD  . ARG A 1 64  ? 30.312 13.657  27.474 1.00 27.34 ? 64  ARG A CD  1 
ATOM   555  N  NE  . ARG A 1 64  ? 28.918 13.470  27.095 1.00 41.14 ? 64  ARG A NE  1 
ATOM   556  C  CZ  . ARG A 1 64  ? 28.387 14.041  26.035 1.00 46.60 ? 64  ARG A CZ  1 
ATOM   557  N  NH1 . ARG A 1 64  ? 29.159 14.726  25.210 1.00 47.36 ? 64  ARG A NH1 1 
ATOM   558  N  NH2 . ARG A 1 64  ? 27.090 13.914  25.818 1.00 52.54 ? 64  ARG A NH2 1 
ATOM   559  N  N   . LEU A 1 65  ? 35.266 12.766  29.460 1.00 7.61  ? 65  LEU A N   1 
ATOM   560  C  CA  . LEU A 1 65  ? 36.449 13.446  29.969 1.00 7.62  ? 65  LEU A CA  1 
ATOM   561  C  C   . LEU A 1 65  ? 37.687 12.965  29.230 1.00 6.89  ? 65  LEU A C   1 
ATOM   562  O  O   . LEU A 1 65  ? 38.561 13.781  28.921 1.00 7.04  ? 65  LEU A O   1 
ATOM   563  C  CB  . LEU A 1 65  ? 36.567 13.182  31.463 1.00 8.10  ? 65  LEU A CB  1 
ATOM   564  C  CG  . LEU A 1 65  ? 35.603 13.980  32.343 1.00 8.77  ? 65  LEU A CG  1 
ATOM   565  C  CD1 . LEU A 1 65  ? 35.432 13.321  33.685 1.00 10.13 ? 65  LEU A CD1 1 
ATOM   566  C  CD2 . LEU A 1 65  ? 36.119 15.367  32.538 1.00 9.94  ? 65  LEU A CD2 1 
ATOM   567  N  N   . LEU A 1 66  ? 37.818 11.647  29.005 1.00 6.78  ? 66  LEU A N   1 
ATOM   568  C  CA  . LEU A 1 66  ? 39.001 11.099  28.347 1.00 6.75  ? 66  LEU A CA  1 
ATOM   569  C  C   . LEU A 1 66  ? 39.066 11.541  26.897 1.00 7.32  ? 66  LEU A C   1 
ATOM   570  O  O   . LEU A 1 66  ? 40.158 11.901  26.392 1.00 7.83  ? 66  LEU A O   1 
ATOM   571  C  CB  . LEU A 1 66  ? 38.961 9.575   28.487 1.00 7.11  ? 66  LEU A CB  1 
ATOM   572  C  CG  . LEU A 1 66  ? 39.294 9.034   29.867 1.00 7.18  ? 66  LEU A CG  1 
ATOM   573  C  CD1 . LEU A 1 66  ? 38.850 7.610   29.972 1.00 7.50  ? 66  LEU A CD1 1 
ATOM   574  C  CD2 . LEU A 1 66  ? 40.740 9.192   30.188 1.00 7.35  ? 66  LEU A CD2 1 
ATOM   575  N  N   . LYS A 1 67  ? 37.935 11.555  26.208 1.00 7.53  ? 67  LYS A N   1 
ATOM   576  C  CA  . LYS A 1 67  ? 37.870 12.063  24.847 1.00 8.15  ? 67  LYS A CA  1 
ATOM   577  C  C   . LYS A 1 67  ? 38.350 13.521  24.822 1.00 7.86  ? 67  LYS A C   1 
ATOM   578  O  O   . LYS A 1 67  ? 39.148 13.915  23.950 1.00 8.02  ? 67  LYS A O   1 
ATOM   579  C  CB  . LYS A 1 67  ? 36.475 11.874  24.279 1.00 10.71 ? 67  LYS A CB  1 
ATOM   580  C  CG  . LYS A 1 67  ? 36.342 12.469  22.914 1.00 15.41 ? 67  LYS A CG  1 
ATOM   581  C  CD  . LYS A 1 67  ? 35.003 12.110  22.289 1.00 23.56 ? 67  LYS A CD  1 
ATOM   582  C  CE  . LYS A 1 67  ? 34.823 12.699  20.905 1.00 29.85 ? 67  LYS A CE  1 
ATOM   583  N  NZ  . LYS A 1 67  ? 33.480 12.331  20.446 1.00 37.62 ? 67  LYS A NZ  1 
ATOM   584  N  N   . MET A 1 68  ? 37.880 14.307  25.774 1.00 7.74  ? 68  MET A N   1 
ATOM   585  C  CA  . MET A 1 68  ? 38.246 15.713  25.833 1.00 8.29  ? 68  MET A CA  1 
ATOM   586  C  C   . MET A 1 68  ? 39.728 15.883  26.107 1.00 7.86  ? 68  MET A C   1 
ATOM   587  O  O   . MET A 1 68  ? 40.399 16.737  25.499 1.00 8.86  ? 68  MET A O   1 
ATOM   588  C  CB  . MET A 1 68  ? 37.396 16.448  26.857 1.00 7.90  ? 68  MET A CB  1 
ATOM   589  C  CG  . MET A 1 68  ? 37.718 17.930  26.980 1.00 8.43  ? 68  MET A CG  1 
ATOM   590  S  SD  . MET A 1 68  ? 39.078 18.263  28.092 1.00 9.92  ? 68  MET A SD  1 
ATOM   591  C  CE  . MET A 1 68  ? 38.219 17.948  29.632 1.00 9.45  ? 68  MET A CE  1 
ATOM   592  N  N   . GLN A 1 69  ? 40.292 15.078  26.996 1.00 7.52  ? 69  GLN A N   1 
ATOM   593  C  CA  . GLN A 1 69  ? 41.700 15.144  27.301 1.00 7.41  ? 69  GLN A CA  1 
ATOM   594  C  C   . GLN A 1 69  ? 42.506 15.006  26.013 1.00 7.13  ? 69  GLN A C   1 
ATOM   595  O  O   . GLN A 1 69  ? 43.432 15.787  25.755 1.00 7.70  ? 69  GLN A O   1 
ATOM   596  C  CB  . GLN A 1 69  ? 42.001 14.046  28.315 1.00 7.84  ? 69  GLN A CB  1 
ATOM   597  C  CG  . GLN A 1 69  ? 43.452 13.905  28.762 1.00 8.37  ? 69  GLN A CG  1 
ATOM   598  C  CD  . GLN A 1 69  ? 43.875 14.913  29.795 1.00 8.23  ? 69  GLN A CD  1 
ATOM   599  O  OE1 . GLN A 1 69  ? 44.013 16.102  29.508 1.00 10.25 ? 69  GLN A OE1 1 
ATOM   600  N  NE2 . GLN A 1 69  ? 44.034 14.497  31.043 1.00 8.27  ? 69  GLN A NE2 1 
ATOM   601  N  N   . ASN A 1 70  ? 42.141 14.019  25.202 1.00 7.43  ? 70  ASN A N   1 
ATOM   602  C  CA  . ASN A 1 70  ? 42.859 13.799  23.948 1.00 7.79  ? 70  ASN A CA  1 
ATOM   603  C  C   . ASN A 1 70  ? 42.577 14.946  22.977 1.00 7.67  ? 70  ASN A C   1 
ATOM   604  O  O   . ASN A 1 70  ? 43.455 15.372  22.221 1.00 7.10  ? 70  ASN A O   1 
ATOM   605  C  CB  . ASN A 1 70  ? 42.481 12.461  23.350 1.00 7.91  ? 70  ASN A CB  1 
ATOM   606  C  CG  . ASN A 1 70  ? 43.328 11.335  23.876 1.00 8.10  ? 70  ASN A CG  1 
ATOM   607  O  OD1 . ASN A 1 70  ? 44.277 11.577  24.622 1.00 10.99 ? 70  ASN A OD1 1 
ATOM   608  N  ND2 . ASN A 1 70  ? 42.996 10.109  23.500 1.00 7.70  ? 70  ASN A ND2 1 
ATOM   609  N  N   . GLN A 1 71  ? 41.356 15.432  22.943 1.00 7.94  ? 71  GLN A N   1 
ATOM   610  C  CA  . GLN A 1 71  ? 41.068 16.524  21.987 1.00 8.22  ? 71  GLN A CA  1 
ATOM   611  C  C   . GLN A 1 71  ? 41.916 17.750  22.286 1.00 8.59  ? 71  GLN A C   1 
ATOM   612  O  O   . GLN A 1 71  ? 42.297 18.490  21.372 1.00 9.52  ? 71  GLN A O   1 
ATOM   613  C  CB  . GLN A 1 71  ? 39.605 16.956  22.054 1.00 9.82  ? 71  GLN A CB  1 
ATOM   614  C  CG  . GLN A 1 71  ? 38.658 15.939  21.465 1.00 11.20 ? 71  GLN A CG  1 
ATOM   615  C  CD  . GLN A 1 71  ? 37.217 16.271  21.740 1.00 16.27 ? 71  GLN A CD  1 
ATOM   616  O  OE1 . GLN A 1 71  ? 36.861 16.727  22.827 1.00 21.32 ? 71  GLN A OE1 1 
ATOM   617  N  NE2 . GLN A 1 71  ? 36.373 16.093  20.742 1.00 24.26 ? 71  GLN A NE2 1 
ATOM   618  N  N   . ARG A 1 72  ? 42.207 17.972  23.564 1.00 8.26  ? 72  ARG A N   1 
ATOM   619  C  CA  . ARG A 1 72  ? 43.025 19.098  23.990 1.00 7.73  ? 72  ARG A CA  1 
ATOM   620  C  C   . ARG A 1 72  ? 44.535 18.861  23.898 1.00 8.67  ? 72  ARG A C   1 
ATOM   621  O  O   . ARG A 1 72  ? 45.337 19.775  24.097 1.00 9.55  ? 72  ARG A O   1 
ATOM   622  C  CB  . ARG A 1 72  ? 42.647 19.563  25.406 1.00 7.19  ? 72  ARG A CB  1 
ATOM   623  C  CG  . ARG A 1 72  ? 41.252 20.166  25.549 1.00 7.49  ? 72  ARG A CG  1 
ATOM   624  C  CD  . ARG A 1 72  ? 41.020 21.428  24.724 1.00 7.26  ? 72  ARG A CD  1 
ATOM   625  N  NE  . ARG A 1 72  ? 41.974 22.497  25.052 1.00 7.66  ? 72  ARG A NE  1 
ATOM   626  C  CZ  . ARG A 1 72  ? 41.810 23.412  26.016 1.00 7.51  ? 72  ARG A CZ  1 
ATOM   627  N  NH1 . ARG A 1 72  ? 40.823 23.309  26.882 1.00 7.57  ? 72  ARG A NH1 1 
ATOM   628  N  NH2 . ARG A 1 72  ? 42.664 24.420  26.089 1.00 7.53  ? 72  ARG A NH2 1 
ATOM   629  N  N   . GLY A 1 73  ? 44.941 17.621  23.664 1.00 9.08  ? 73  GLY A N   1 
ATOM   630  C  CA  . GLY A 1 73  ? 46.352 17.297  23.576 1.00 8.91  ? 73  GLY A CA  1 
ATOM   631  C  C   . GLY A 1 73  ? 47.013 16.962  24.896 1.00 9.31  ? 73  GLY A C   1 
ATOM   632  O  O   . GLY A 1 73  ? 48.236 16.878  24.973 1.00 10.27 ? 73  GLY A O   1 
ATOM   633  N  N   . GLY A 1 74  ? 46.214 16.765  25.953 1.00 9.12  ? 74  GLY A N   1 
ATOM   634  C  CA  . GLY A 1 74  ? 46.719 16.219  27.188 1.00 9.27  ? 74  GLY A CA  1 
ATOM   635  C  C   . GLY A 1 74  ? 46.889 14.700  27.087 1.00 9.56  ? 74  GLY A C   1 
ATOM   636  O  O   . GLY A 1 74  ? 46.521 14.078  26.107 1.00 10.96 ? 74  GLY A O   1 
ATOM   637  N  N   . ARG A 1 75  ? 47.452 14.126  28.134 1.00 8.90  ? 75  ARG A N   1 
ATOM   638  C  CA  . ARG A 1 75  ? 47.742 12.693  28.165 1.00 9.78  ? 75  ARG A CA  1 
ATOM   639  C  C   . ARG A 1 75  ? 46.899 12.056  29.256 1.00 8.32  ? 75  ARG A C   1 
ATOM   640  O  O   . ARG A 1 75  ? 47.049 12.359  30.438 1.00 8.83  ? 75  ARG A O   1 
ATOM   641  C  CB  . ARG A 1 75  ? 49.212 12.378  28.398 1.00 12.28 ? 75  ARG A CB  1 
ATOM   642  C  CG  . ARG A 1 75  ? 49.493 10.873  28.416 1.00 17.99 ? 75  ARG A CG  1 
ATOM   643  C  CD  . ARG A 1 75  ? 50.947 10.435  28.617 1.00 21.57 ? 75  ARG A CD  1 
ATOM   644  N  NE  . ARG A 1 75  ? 51.882 11.002  27.636 1.00 19.84 ? 75  ARG A NE  1 
ATOM   645  C  CZ  . ARG A 1 75  ? 52.108 10.585  26.403 1.00 19.50 ? 75  ARG A CZ  1 
ATOM   646  N  NH1 . ARG A 1 75  ? 51.511 9.528   25.904 1.00 17.35 ? 75  ARG A NH1 1 
ATOM   647  N  NH2 . ARG A 1 75  ? 53.046 11.210  25.687 1.00 20.00 ? 75  ARG A NH2 1 
ATOM   648  N  N   . ALA A 1 76  ? 46.016 11.164  28.852 1.00 7.88  ? 76  ALA A N   1 
ATOM   649  C  CA  . ALA A 1 76  ? 45.243 10.371  29.796 1.00 9.01  ? 76  ALA A CA  1 
ATOM   650  C  C   . ALA A 1 76  ? 46.177 9.475   30.576 1.00 9.28  ? 76  ALA A C   1 
ATOM   651  O  O   . ALA A 1 76  ? 46.988 8.751   29.966 1.00 12.00 ? 76  ALA A O   1 
ATOM   652  C  CB  . ALA A 1 76  ? 44.241 9.540   29.017 1.00 11.01 ? 76  ALA A CB  1 
ATOM   653  N  N   . LEU A 1 77  ? 46.037 9.505   31.914 1.00 8.69  ? 77  LEU A N   1 
ATOM   654  C  CA  . LEU A 1 77  ? 46.831 8.719   32.832 1.00 10.10 ? 77  LEU A CA  1 
ATOM   655  C  C   . LEU A 1 77  ? 45.847 8.097   33.789 1.00 11.35 ? 77  LEU A C   1 
ATOM   656  O  O   . LEU A 1 77  ? 45.020 8.827   34.349 1.00 13.28 ? 77  LEU A O   1 
ATOM   657  C  CB  . LEU A 1 77  ? 47.871 9.541   33.568 1.00 11.97 ? 77  LEU A CB  1 
ATOM   658  C  CG  . LEU A 1 77  ? 49.063 9.960   32.725 1.00 14.75 ? 77  LEU A CG  1 
ATOM   659  C  CD1 . LEU A 1 77  ? 49.909 10.811  33.664 1.00 17.21 ? 77  LEU A CD1 1 
ATOM   660  C  CD2 . LEU A 1 77  ? 49.847 8.793   32.117 1.00 16.31 ? 77  LEU A CD2 1 
ATOM   661  N  N   . PHE A 1 78  ? 45.982 6.789   33.957 1.00 9.48  ? 78  PHE A N   1 
ATOM   662  C  CA  . PHE A 1 78  ? 45.074 6.040   34.795 1.00 9.24  ? 78  PHE A CA  1 
ATOM   663  C  C   . PHE A 1 78  ? 45.764 5.603   36.083 1.00 10.61 ? 78  PHE A C   1 
ATOM   664  O  O   . PHE A 1 78  ? 46.963 5.337   36.091 1.00 12.40 ? 78  PHE A O   1 
ATOM   665  C  CB  . PHE A 1 78  ? 44.604 4.830   34.007 1.00 9.20  ? 78  PHE A CB  1 
ATOM   666  C  CG  . PHE A 1 78  ? 43.801 5.182   32.770 1.00 9.29  ? 78  PHE A CG  1 
ATOM   667  C  CD1 . PHE A 1 78  ? 42.457 5.546   32.911 1.00 11.39 ? 78  PHE A CD1 1 
ATOM   668  C  CD2 . PHE A 1 78  ? 44.389 5.238   31.511 1.00 9.91  ? 78  PHE A CD2 1 
ATOM   669  C  CE1 . PHE A 1 78  ? 41.719 5.911   31.788 1.00 11.59 ? 78  PHE A CE1 1 
ATOM   670  C  CE2 . PHE A 1 78  ? 43.646 5.609   30.400 1.00 9.78  ? 78  PHE A CE2 1 
ATOM   671  C  CZ  . PHE A 1 78  ? 42.308 5.931   30.541 1.00 10.39 ? 78  PHE A CZ  1 
ATOM   672  N  N   . GLN A 1 79  ? 45.010 5.662   37.154 1.00 9.23  ? 79  GLN A N   1 
ATOM   673  C  CA  . GLN A 1 79  ? 45.519 5.250   38.445 1.00 10.37 ? 79  GLN A CA  1 
ATOM   674  C  C   . GLN A 1 79  ? 44.702 4.076   38.934 1.00 8.80  ? 79  GLN A C   1 
ATOM   675  O  O   . GLN A 1 79  ? 43.654 3.743   38.403 1.00 9.61  ? 79  GLN A O   1 
ATOM   676  C  CB  . GLN A 1 79  ? 45.482 6.415   39.453 1.00 12.89 ? 79  GLN A CB  1 
ATOM   677  C  CG  . GLN A 1 79  ? 46.408 7.570   39.084 1.00 16.61 ? 79  GLN A CG  1 
ATOM   678  C  CD  . GLN A 1 79  ? 47.844 7.168   38.832 1.00 25.51 ? 79  GLN A CD  1 
ATOM   679  O  OE1 . GLN A 1 79  ? 48.399 6.238   39.458 1.00 27.00 ? 79  GLN A OE1 1 
ATOM   680  N  NE2 . GLN A 1 79  ? 48.462 7.862   37.872 1.00 32.25 ? 79  GLN A NE2 1 
ATOM   681  N  N   . ASP A 1 80  ? 45.165 3.467   40.037 1.00 8.55  ? 80  ASP A N   1 
ATOM   682  C  CA  . ASP A 1 80  ? 44.390 2.395   40.618 1.00 8.86  ? 80  ASP A CA  1 
ATOM   683  C  C   . ASP A 1 80  ? 43.017 2.925   40.995 1.00 10.12 ? 80  ASP A C   1 
ATOM   684  O  O   . ASP A 1 80  ? 42.845 4.117   41.310 1.00 11.03 ? 80  ASP A O   1 
ATOM   685  C  CB  . ASP A 1 80  ? 45.125 1.967   41.889 1.00 10.09 ? 80  ASP A CB  1 
ATOM   686  C  CG  . ASP A 1 80  ? 46.485 1.323   41.729 1.00 11.46 ? 80  ASP A CG  1 
ATOM   687  O  OD1 . ASP A 1 80  ? 46.792 0.714   40.697 1.00 8.96  ? 80  ASP A OD1 1 
ATOM   688  O  OD2 . ASP A 1 80  ? 47.317 1.327   42.666 1.00 14.77 ? 80  ASP A OD2 1 
ATOM   689  N  N   . LEU A 1 81  ? 42.029 2.051   40.949 1.00 10.48 ? 81  LEU A N   1 
ATOM   690  C  CA  A LEU A 1 81  ? 40.665 2.412   41.299 0.70 11.04 ? 81  LEU A CA  1 
ATOM   691  C  CA  B LEU A 1 81  ? 40.664 2.411   41.287 0.30 10.65 ? 81  LEU A CA  1 
ATOM   692  C  C   . LEU A 1 81  ? 40.333 1.806   42.651 1.00 10.82 ? 81  LEU A C   1 
ATOM   693  O  O   . LEU A 1 81  ? 40.273 0.585   42.780 1.00 12.27 ? 81  LEU A O   1 
ATOM   694  C  CB  A LEU A 1 81  ? 39.636 1.971   40.261 0.70 13.96 ? 81  LEU A CB  1 
ATOM   695  C  CB  B LEU A 1 81  ? 39.750 1.911   40.164 0.30 11.50 ? 81  LEU A CB  1 
ATOM   696  C  CG  A LEU A 1 81  ? 39.709 2.717   38.934 0.70 13.86 ? 81  LEU A CG  1 
ATOM   697  C  CG  B LEU A 1 81  ? 38.437 2.670   39.948 0.30 11.28 ? 81  LEU A CG  1 
ATOM   698  C  CD1 A LEU A 1 81  ? 38.855 1.980   37.931 0.70 15.41 ? 81  LEU A CD1 1 
ATOM   699  C  CD1 B LEU A 1 81  ? 38.702 4.138   39.600 0.30 12.02 ? 81  LEU A CD1 1 
ATOM   700  C  CD2 A LEU A 1 81  ? 39.312 4.156   39.016 0.70 14.84 ? 81  LEU A CD2 1 
ATOM   701  C  CD2 B LEU A 1 81  ? 37.651 1.969   38.842 0.30 10.95 ? 81  LEU A CD2 1 
ATOM   702  N  N   . GLN A 1 82  ? 40.099 2.656   43.647 1.00 9.58  ? 82  GLN A N   1 
ATOM   703  C  CA  . GLN A 1 82  ? 39.748 2.160   44.972 1.00 11.23 ? 82  GLN A CA  1 
ATOM   704  C  C   . GLN A 1 82  ? 38.383 1.464   44.902 1.00 11.05 ? 82  GLN A C   1 
ATOM   705  O  O   . GLN A 1 82  ? 37.444 1.952   44.252 1.00 11.77 ? 82  GLN A O   1 
ATOM   706  C  CB  . GLN A 1 82  ? 39.571 3.252   46.016 1.00 16.14 ? 82  GLN A CB  1 
ATOM   707  C  CG  . GLN A 1 82  ? 40.694 4.242   46.234 1.00 25.15 ? 82  GLN A CG  1 
ATOM   708  C  CD  . GLN A 1 82  ? 40.037 5.522   46.699 1.00 28.83 ? 82  GLN A CD  1 
ATOM   709  O  OE1 . GLN A 1 82  ? 40.108 6.549   46.016 1.00 33.94 ? 82  GLN A OE1 1 
ATOM   710  N  NE2 . GLN A 1 82  ? 39.228 5.374   47.752 1.00 28.89 ? 82  GLN A NE2 1 
ATOM   711  N  N   . LYS A 1 83  ? 38.260 0.406   45.689 1.00 9.81  ? 83  LYS A N   1 
ATOM   712  C  CA  . LYS A 1 83  ? 37.002 -0.294  45.824 1.00 9.89  ? 83  LYS A CA  1 
ATOM   713  C  C   . LYS A 1 83  ? 35.992 0.618   46.505 1.00 9.23  ? 83  LYS A C   1 
ATOM   714  O  O   . LYS A 1 83  ? 36.317 1.566   47.221 1.00 9.22  ? 83  LYS A O   1 
ATOM   715  C  CB  . LYS A 1 83  ? 37.151 -1.586  46.615 1.00 10.06 ? 83  LYS A CB  1 
ATOM   716  C  CG  . LYS A 1 83  ? 37.454 -1.449  48.055 1.00 10.67 ? 83  LYS A CG  1 
ATOM   717  C  CD  . LYS A 1 83  ? 37.662 -2.794  48.742 1.00 12.83 ? 83  LYS A CD  1 
ATOM   718  C  CE  . LYS A 1 83  ? 37.535 -2.663  50.203 1.00 14.20 ? 83  LYS A CE  1 
ATOM   719  N  NZ  . LYS A 1 83  ? 37.813 -3.961  50.850 1.00 16.77 ? 83  LYS A NZ  1 
ATOM   720  N  N   . PRO A 1 84  ? 34.695 0.295   46.334 1.00 7.90  ? 84  PRO A N   1 
ATOM   721  C  CA  . PRO A 1 84  ? 33.664 1.090   47.023 1.00 8.54  ? 84  PRO A CA  1 
ATOM   722  C  C   . PRO A 1 84  ? 33.766 1.045   48.543 1.00 9.57  ? 84  PRO A C   1 
ATOM   723  O  O   . PRO A 1 84  ? 34.376 0.134   49.114 1.00 10.49 ? 84  PRO A O   1 
ATOM   724  C  CB  . PRO A 1 84  ? 32.341 0.456   46.495 1.00 7.91  ? 84  PRO A CB  1 
ATOM   725  C  CG  . PRO A 1 84  ? 32.765 -0.144  45.177 1.00 8.01  ? 84  PRO A CG  1 
ATOM   726  C  CD  . PRO A 1 84  ? 34.126 -0.753  45.486 1.00 7.72  ? 84  PRO A CD  1 
ATOM   727  N  N   . SER A 1 85  ? 33.152 2.044   49.168 1.00 9.57  ? 85  SER A N   1 
ATOM   728  C  CA  . SER A 1 85  ? 33.294 2.279   50.588 1.00 10.40 ? 85  SER A CA  1 
ATOM   729  C  C   . SER A 1 85  ? 32.651 1.199   51.444 1.00 10.93 ? 85  SER A C   1 
ATOM   730  O  O   . SER A 1 85  ? 33.042 1.068   52.604 1.00 13.01 ? 85  SER A O   1 
ATOM   731  C  CB  . SER A 1 85  ? 32.777 3.646   50.964 1.00 12.12 ? 85  SER A CB  1 
ATOM   732  O  OG  . SER A 1 85  ? 31.376 3.798   50.787 1.00 16.97 ? 85  SER A OG  1 
ATOM   733  N  N   . GLN A 1 86  ? 31.678 0.461   50.913 1.00 9.56  ? 86  GLN A N   1 
ATOM   734  C  CA  A GLN A 1 86  ? 30.963 -0.577  51.652 0.60 9.36  ? 86  GLN A CA  1 
ATOM   735  C  CA  B GLN A 1 86  ? 30.952 -0.574  51.644 0.40 9.84  ? 86  GLN A CA  1 
ATOM   736  C  C   . GLN A 1 86  ? 30.860 -1.836  50.787 1.00 9.05  ? 86  GLN A C   1 
ATOM   737  O  O   . GLN A 1 86  ? 30.864 -1.755  49.566 1.00 8.70  ? 86  GLN A O   1 
ATOM   738  C  CB  A GLN A 1 86  ? 29.562 -0.091  52.052 0.60 10.10 ? 86  GLN A CB  1 
ATOM   739  C  CB  B GLN A 1 86  ? 29.513 -0.146  51.961 0.40 11.07 ? 86  GLN A CB  1 
ATOM   740  C  CG  A GLN A 1 86  ? 29.587 1.187   52.883 0.60 11.04 ? 86  GLN A CG  1 
ATOM   741  C  CG  B GLN A 1 86  ? 29.418 1.128   52.786 0.40 12.49 ? 86  GLN A CG  1 
ATOM   742  C  CD  A GLN A 1 86  ? 28.229 1.825   53.051 0.60 13.18 ? 86  GLN A CD  1 
ATOM   743  C  CD  B GLN A 1 86  ? 29.893 0.932   54.207 0.40 15.36 ? 86  GLN A CD  1 
ATOM   744  O  OE1 A GLN A 1 86  ? 28.076 3.060   53.145 0.60 16.49 ? 86  GLN A OE1 1 
ATOM   745  O  OE1 B GLN A 1 86  ? 30.297 1.883   54.895 0.40 20.09 ? 86  GLN A OE1 1 
ATOM   746  N  NE2 A GLN A 1 86  ? 27.244 0.958   53.212 0.60 13.15 ? 86  GLN A NE2 1 
ATOM   747  N  NE2 B GLN A 1 86  ? 29.847 -0.305  54.668 0.40 15.03 ? 86  GLN A NE2 1 
ATOM   748  N  N   . ASP A 1 87  ? 30.774 -2.996  51.456 1.00 8.73  ? 87  ASP A N   1 
ATOM   749  C  CA  . ASP A 1 87  ? 30.446 -4.261  50.818 1.00 9.03  ? 87  ASP A CA  1 
ATOM   750  C  C   . ASP A 1 87  ? 28.955 -4.572  50.828 1.00 10.13 ? 87  ASP A C   1 
ATOM   751  O  O   . ASP A 1 87  ? 28.500 -5.315  49.957 1.00 10.54 ? 87  ASP A O   1 
ATOM   752  C  CB  . ASP A 1 87  ? 31.181 -5.396  51.494 1.00 9.84  ? 87  ASP A CB  1 
ATOM   753  C  CG  . ASP A 1 87  ? 32.696 -5.298  51.406 1.00 10.51 ? 87  ASP A CG  1 
ATOM   754  O  OD1 . ASP A 1 87  ? 33.193 -4.821  50.370 1.00 10.13 ? 87  ASP A OD1 1 
ATOM   755  O  OD2 . ASP A 1 87  ? 33.333 -5.720  52.396 1.00 12.61 ? 87  ASP A OD2 1 
ATOM   756  N  N   . GLU A 1 88  ? 28.248 -4.028  51.810 1.00 9.56  ? 88  GLU A N   1 
ATOM   757  C  CA  . GLU A 1 88  ? 26.808 -4.204  51.946 1.00 11.00 ? 88  GLU A CA  1 
ATOM   758  C  C   . GLU A 1 88  ? 26.239 -2.813  52.199 1.00 9.68  ? 88  GLU A C   1 
ATOM   759  O  O   . GLU A 1 88  ? 26.819 -2.019  52.908 1.00 11.18 ? 88  GLU A O   1 
ATOM   760  C  CB  . GLU A 1 88  ? 26.499 -5.110  53.147 1.00 13.60 ? 88  GLU A CB  1 
ATOM   761  C  CG  . GLU A 1 88  ? 27.029 -6.519  52.978 1.00 18.03 ? 88  GLU A CG  1 
ATOM   762  C  CD  . GLU A 1 88  ? 26.550 -7.385  54.128 1.00 28.16 ? 88  GLU A CD  1 
ATOM   763  O  OE1 . GLU A 1 88  ? 26.961 -7.131  55.264 1.00 34.95 ? 88  GLU A OE1 1 
ATOM   764  O  OE2 . GLU A 1 88  ? 25.703 -8.254  53.883 1.00 34.68 ? 88  GLU A OE2 1 
ATOM   765  N  N   . TRP A 1 89  ? 25.079 -2.514  51.620 1.00 8.46  ? 89  TRP A N   1 
ATOM   766  C  CA  . TRP A 1 89  ? 24.619 -1.145  51.509 1.00 8.62  ? 89  TRP A CA  1 
ATOM   767  C  C   . TRP A 1 89  ? 23.364 -0.813  52.304 1.00 9.23  ? 89  TRP A C   1 
ATOM   768  O  O   . TRP A 1 89  ? 22.856 0.310   52.175 1.00 10.58 ? 89  TRP A O   1 
ATOM   769  C  CB  . TRP A 1 89  ? 24.464 -0.726  50.037 1.00 8.14  ? 89  TRP A CB  1 
ATOM   770  C  CG  . TRP A 1 89  ? 25.777 -0.765  49.270 1.00 7.80  ? 89  TRP A CG  1 
ATOM   771  C  CD1 . TRP A 1 89  ? 26.212 -1.792  48.487 1.00 8.02  ? 89  TRP A CD1 1 
ATOM   772  C  CD2 . TRP A 1 89  ? 26.785 0.270   49.199 1.00 7.77  ? 89  TRP A CD2 1 
ATOM   773  N  NE1 . TRP A 1 89  ? 27.441 -1.465  47.940 1.00 7.47  ? 89  TRP A NE1 1 
ATOM   774  C  CE2 . TRP A 1 89  ? 27.807 -0.227  48.374 1.00 7.81  ? 89  TRP A CE2 1 
ATOM   775  C  CE3 . TRP A 1 89  ? 26.889 1.533   49.759 1.00 8.36  ? 89  TRP A CE3 1 
ATOM   776  C  CZ2 . TRP A 1 89  ? 28.931 0.519   48.090 1.00 7.92  ? 89  TRP A CZ2 1 
ATOM   777  C  CZ3 . TRP A 1 89  ? 27.998 2.287   49.480 1.00 8.80  ? 89  TRP A CZ3 1 
ATOM   778  C  CH2 . TRP A 1 89  ? 29.008 1.762   48.671 1.00 8.37  ? 89  TRP A CH2 1 
ATOM   779  N  N   . GLY A 1 90  ? 22.944 -1.731  53.165 1.00 9.03  ? 90  GLY A N   1 
ATOM   780  C  CA  . GLY A 1 90  ? 21.807 -1.468  54.053 1.00 9.35  ? 90  GLY A CA  1 
ATOM   781  C  C   . GLY A 1 90  ? 20.487 -1.368  53.315 1.00 8.35  ? 90  GLY A C   1 
ATOM   782  O  O   . GLY A 1 90  ? 20.181 -2.169  52.453 1.00 8.57  ? 90  GLY A O   1 
ATOM   783  N  N   . THR A 1 91  ? 19.674 -0.407  53.747 1.00 8.34  ? 91  THR A N   1 
ATOM   784  C  CA  . THR A 1 91  ? 18.362 -0.247  53.167 1.00 8.52  ? 91  THR A CA  1 
ATOM   785  C  C   . THR A 1 91  ? 18.411 0.636   51.924 1.00 8.07  ? 91  THR A C   1 
ATOM   786  O  O   . THR A 1 91  ? 19.443 1.258   51.607 1.00 8.65  ? 91  THR A O   1 
ATOM   787  C  CB  . THR A 1 91  ? 17.395 0.381   54.168 1.00 9.47  ? 91  THR A CB  1 
ATOM   788  O  OG1 . THR A 1 91  ? 17.886 1.681   54.468 1.00 9.93  ? 91  THR A OG1 1 
ATOM   789  C  CG2 . THR A 1 91  ? 17.313 -0.346  55.485 1.00 10.61 ? 91  THR A CG2 1 
ATOM   790  N  N   . THR A 1 92  ? 17.294 0.684   51.189 1.00 8.91  ? 92  THR A N   1 
ATOM   791  C  CA  . THR A 1 92  ? 17.188 1.632   50.089 1.00 7.92  ? 92  THR A CA  1 
ATOM   792  C  C   . THR A 1 92  ? 17.528 3.030   50.574 1.00 8.47  ? 92  THR A C   1 
ATOM   793  O  O   . THR A 1 92  ? 18.207 3.784   49.874 1.00 8.71  ? 92  THR A O   1 
ATOM   794  C  CB  . THR A 1 92  ? 15.800 1.617   49.434 1.00 8.88  ? 92  THR A CB  1 
ATOM   795  O  OG1 . THR A 1 92  ? 15.535 0.259   49.012 1.00 8.89  ? 92  THR A OG1 1 
ATOM   796  C  CG2 . THR A 1 92  ? 15.813 2.497   48.197 1.00 8.95  ? 92  THR A CG2 1 
ATOM   797  N  N   . LEU A 1 93  ? 17.035 3.406   51.769 1.00 7.99  ? 93  LEU A N   1 
ATOM   798  C  CA  . LEU A 1 93  ? 17.327 4.736   52.296 1.00 8.01  ? 93  LEU A CA  1 
ATOM   799  C  C   . LEU A 1 93  ? 18.834 4.923   52.499 1.00 8.22  ? 93  LEU A C   1 
ATOM   800  O  O   . LEU A 1 93  ? 19.381 5.954   52.116 1.00 8.83  ? 93  LEU A O   1 
ATOM   801  C  CB  . LEU A 1 93  ? 16.587 4.924   53.614 1.00 9.65  ? 93  LEU A CB  1 
ATOM   802  C  CG  . LEU A 1 93  ? 16.783 6.275   54.291 1.00 12.28 ? 93  LEU A CG  1 
ATOM   803  C  CD1 . LEU A 1 93  ? 16.461 7.433   53.417 1.00 14.07 ? 93  LEU A CD1 1 
ATOM   804  C  CD2 . LEU A 1 93  ? 15.918 6.255   55.533 1.00 14.99 ? 93  LEU A CD2 1 
ATOM   805  N  N   . ASP A 1 94  ? 19.484 3.939   53.125 1.00 7.99  ? 94  ASP A N   1 
ATOM   806  C  CA  . ASP A 1 94  ? 20.920 4.023   53.341 1.00 8.37  ? 94  ASP A CA  1 
ATOM   807  C  C   . ASP A 1 94  ? 21.636 4.216   52.027 1.00 8.11  ? 94  ASP A C   1 
ATOM   808  O  O   . ASP A 1 94  ? 22.589 4.997   51.918 1.00 8.44  ? 94  ASP A O   1 
ATOM   809  C  CB  . ASP A 1 94  ? 21.444 2.775   54.020 1.00 8.74  ? 94  ASP A CB  1 
ATOM   810  C  CG  . ASP A 1 94  ? 20.971 2.539   55.446 1.00 10.80 ? 94  ASP A CG  1 
ATOM   811  O  OD1 . ASP A 1 94  ? 20.906 3.540   56.205 1.00 14.00 ? 94  ASP A OD1 1 
ATOM   812  O  OD2 . ASP A 1 94  ? 20.807 1.370   55.810 1.00 11.06 ? 94  ASP A OD2 1 
ATOM   813  N  N   . ALA A 1 95  ? 21.223 3.435   51.026 1.00 7.39  ? 95  ALA A N   1 
ATOM   814  C  CA  . ALA A 1 95  ? 21.873 3.440   49.730 1.00 7.59  ? 95  ALA A CA  1 
ATOM   815  C  C   . ALA A 1 95  ? 21.683 4.781   49.023 1.00 7.90  ? 95  ALA A C   1 
ATOM   816  O  O   . ALA A 1 95  ? 22.618 5.336   48.443 1.00 8.57  ? 95  ALA A O   1 
ATOM   817  C  CB  . ALA A 1 95  ? 21.370 2.293   48.881 1.00 7.77  ? 95  ALA A CB  1 
ATOM   818  N  N   . MET A 1 96  ? 20.464 5.316   49.070 1.00 7.93  ? 96  MET A N   1 
ATOM   819  C  CA  . MET A 1 96  ? 20.204 6.577   48.398 1.00 8.05  ? 96  MET A CA  1 
ATOM   820  C  C   . MET A 1 96  ? 20.957 7.722   49.109 1.00 8.69  ? 96  MET A C   1 
ATOM   821  O  O   . MET A 1 96  ? 21.430 8.652   48.452 1.00 8.65  ? 96  MET A O   1 
ATOM   822  C  CB  . MET A 1 96  ? 18.700 6.844   48.316 1.00 8.52  ? 96  MET A CB  1 
ATOM   823  C  CG  . MET A 1 96  ? 18.324 7.940   47.341 1.00 9.22  ? 96  MET A CG  1 
ATOM   824  S  SD  . MET A 1 96  ? 18.577 7.486   45.624 1.00 10.38 ? 96  MET A SD  1 
ATOM   825  C  CE  . MET A 1 96  ? 17.416 6.129   45.429 1.00 10.39 ? 96  MET A CE  1 
ATOM   826  N  N   . LYS A 1 97  ? 21.080 7.656   50.442 1.00 9.00  ? 97  LYS A N   1 
ATOM   827  C  CA  . LYS A 1 97  ? 21.883 8.657   51.151 1.00 10.03 ? 97  LYS A CA  1 
ATOM   828  C  C   . LYS A 1 97  ? 23.349 8.556   50.733 1.00 10.27 ? 97  LYS A C   1 
ATOM   829  O  O   . LYS A 1 97  ? 24.001 9.574   50.470 1.00 10.47 ? 97  LYS A O   1 
ATOM   830  C  CB  . LYS A 1 97  ? 21.788 8.487   52.652 1.00 10.97 ? 97  LYS A CB  1 
ATOM   831  C  CG  . LYS A 1 97  ? 20.476 8.933   53.302 1.00 13.36 ? 97  LYS A CG  1 
ATOM   832  C  CD  . LYS A 1 97  ? 20.447 8.586   54.789 1.00 18.38 ? 97  LYS A CD  1 
ATOM   833  C  CE  . LYS A 1 97  ? 19.293 9.182   55.562 1.00 27.19 ? 97  LYS A CE  1 
ATOM   834  N  NZ  . LYS A 1 97  ? 19.114 8.541   56.888 1.00 34.76 ? 97  LYS A NZ  1 
ATOM   835  N  N   . ALA A 1 98  ? 23.883 7.337   50.616 1.00 8.33  ? 98  ALA A N   1 
ATOM   836  C  CA  . ALA A 1 98  ? 25.279 7.182   50.180 1.00 8.33  ? 98  ALA A CA  1 
ATOM   837  C  C   . ALA A 1 98  ? 25.461 7.715   48.773 1.00 8.69  ? 98  ALA A C   1 
ATOM   838  O  O   . ALA A 1 98  ? 26.479 8.352   48.479 1.00 8.65  ? 98  ALA A O   1 
ATOM   839  C  CB  . ALA A 1 98  ? 25.696 5.747   50.278 1.00 9.23  ? 98  ALA A CB  1 
ATOM   840  N  N   . ALA A 1 99  ? 24.482 7.499   47.905 1.00 8.27  ? 99  ALA A N   1 
ATOM   841  C  CA  . ALA A 1 99  ? 24.549 7.969   46.541 1.00 8.56  ? 99  ALA A CA  1 
ATOM   842  C  C   . ALA A 1 99  ? 24.545 9.488   46.478 1.00 8.45  ? 99  ALA A C   1 
ATOM   843  O  O   . ALA A 1 99  ? 25.290 10.087  45.700 1.00 8.93  ? 99  ALA A O   1 
ATOM   844  C  CB  . ALA A 1 99  ? 23.416 7.401   45.753 1.00 9.64  ? 99  ALA A CB  1 
ATOM   845  N  N   . ILE A 1 100 ? 23.717 10.153  47.283 1.00 8.56  ? 100 ILE A N   1 
ATOM   846  C  CA  A ILE A 1 100 ? 23.696 11.599  47.200 0.58 8.16  ? 100 ILE A CA  1 
ATOM   847  C  CA  B ILE A 1 100 ? 23.691 11.605  47.267 0.42 8.58  ? 100 ILE A CA  1 
ATOM   848  C  C   . ILE A 1 100 ? 25.010 12.180  47.777 1.00 8.02  ? 100 ILE A C   1 
ATOM   849  O  O   . ILE A 1 100 ? 25.523 13.165  47.239 1.00 9.68  ? 100 ILE A O   1 
ATOM   850  C  CB  A ILE A 1 100 ? 22.407 12.163  47.830 0.58 8.25  ? 100 ILE A CB  1 
ATOM   851  C  CB  B ILE A 1 100 ? 22.522 12.130  48.103 0.42 9.11  ? 100 ILE A CB  1 
ATOM   852  C  CG1 A ILE A 1 100 ? 22.100 13.510  47.188 0.58 8.64  ? 100 ILE A CG1 1 
ATOM   853  C  CG1 B ILE A 1 100 ? 21.274 11.976  47.316 0.42 9.37  ? 100 ILE A CG1 1 
ATOM   854  C  CG2 A ILE A 1 100 ? 22.529 12.280  49.340 0.58 7.97  ? 100 ILE A CG2 1 
ATOM   855  C  CG2 B ILE A 1 100 ? 22.772 13.586  48.504 0.42 9.62  ? 100 ILE A CG2 1 
ATOM   856  C  CD1 A ILE A 1 100 ? 20.752 14.095  47.574 0.58 9.13  ? 100 ILE A CD1 1 
ATOM   857  C  CD1 B ILE A 1 100 ? 20.032 12.240  48.119 0.42 9.74  ? 100 ILE A CD1 1 
ATOM   858  N  N   . VAL A 1 101 ? 25.577 11.562  48.809 1.00 7.95  ? 101 VAL A N   1 
ATOM   859  C  CA  . VAL A 1 101 ? 26.882 11.984  49.315 1.00 8.95  ? 101 VAL A CA  1 
ATOM   860  C  C   . VAL A 1 101 ? 27.926 11.858  48.186 1.00 9.14  ? 101 VAL A C   1 
ATOM   861  O  O   . VAL A 1 101 ? 28.754 12.774  47.946 1.00 10.35 ? 101 VAL A O   1 
ATOM   862  C  CB  . VAL A 1 101 ? 27.266 11.177  50.565 1.00 10.02 ? 101 VAL A CB  1 
ATOM   863  C  CG1 . VAL A 1 101 ? 28.750 11.355  50.905 1.00 10.92 ? 101 VAL A CG1 1 
ATOM   864  C  CG2 . VAL A 1 101 ? 26.339 11.505  51.725 1.00 10.91 ? 101 VAL A CG2 1 
ATOM   865  N  N   . LEU A 1 102 ? 27.929 10.728  47.507 1.00 8.27  ? 102 LEU A N   1 
ATOM   866  C  CA  . LEU A 1 102 ? 28.825 10.496  46.379 1.00 9.04  ? 102 LEU A CA  1 
ATOM   867  C  C   . LEU A 1 102 ? 28.632 11.565  45.314 1.00 9.00  ? 102 LEU A C   1 
ATOM   868  O  O   . LEU A 1 102 ? 29.591 12.187  44.837 1.00 10.00 ? 102 LEU A O   1 
ATOM   869  C  CB  . LEU A 1 102 ? 28.581 9.111   45.788 1.00 10.37 ? 102 LEU A CB  1 
ATOM   870  C  CG  . LEU A 1 102 ? 29.377 8.710   44.559 1.00 11.54 ? 102 LEU A CG  1 
ATOM   871  C  CD1 . LEU A 1 102 ? 30.869 8.849   44.756 1.00 14.48 ? 102 LEU A CD1 1 
ATOM   872  C  CD2 . LEU A 1 102 ? 29.014 7.260   44.214 1.00 13.16 ? 102 LEU A CD2 1 
ATOM   873  N  N   . GLU A 1 103 ? 27.399 11.832  44.937 1.00 8.60  ? 103 GLU A N   1 
ATOM   874  C  CA  . GLU A 1 103 ? 27.168 12.813  43.892 1.00 8.47  ? 103 GLU A CA  1 
ATOM   875  C  C   . GLU A 1 103 ? 27.565 14.228  44.311 1.00 8.15  ? 103 GLU A C   1 
ATOM   876  O  O   . GLU A 1 103 ? 28.125 14.953  43.471 1.00 9.10  ? 103 GLU A O   1 
ATOM   877  C  CB  . GLU A 1 103 ? 25.699 12.801  43.495 1.00 8.88  ? 103 GLU A CB  1 
ATOM   878  C  CG  . GLU A 1 103 ? 25.315 11.538  42.748 1.00 10.04 ? 103 GLU A CG  1 
ATOM   879  C  CD  . GLU A 1 103 ? 26.112 11.217  41.520 1.00 11.08 ? 103 GLU A CD  1 
ATOM   880  O  OE1 . GLU A 1 103 ? 26.513 12.137  40.772 1.00 11.06 ? 103 GLU A OE1 1 
ATOM   881  O  OE2 . GLU A 1 103 ? 26.384 10.022  41.226 1.00 12.43 ? 103 GLU A OE2 1 
ATOM   882  N  N   . LYS A 1 104 ? 27.320 14.619  45.548 1.00 9.42  ? 104 LYS A N   1 
ATOM   883  C  CA  . LYS A 1 104 ? 27.758 15.934  46.012 1.00 10.39 ? 104 LYS A CA  1 
ATOM   884  C  C   . LYS A 1 104 ? 29.283 16.043  45.939 1.00 10.59 ? 104 LYS A C   1 
ATOM   885  O  O   . LYS A 1 104 ? 29.811 17.106  45.603 1.00 9.57  ? 104 LYS A O   1 
ATOM   886  C  CB  . LYS A 1 104 ? 27.293 16.232  47.436 1.00 13.30 ? 104 LYS A CB  1 
ATOM   887  C  CG  . LYS A 1 104 ? 25.796 16.566  47.398 1.00 17.07 ? 104 LYS A CG  1 
ATOM   888  C  CD  . LYS A 1 104 ? 25.308 16.601  48.829 1.00 21.34 ? 104 LYS A CD  1 
ATOM   889  C  CE  . LYS A 1 104 ? 24.054 17.342  48.983 1.00 23.31 ? 104 LYS A CE  1 
ATOM   890  N  NZ  . LYS A 1 104 ? 23.693 17.109  50.395 1.00 23.94 ? 104 LYS A NZ  1 
ATOM   891  N  N   . SER A 1 105 ? 29.980 14.926  46.192 1.00 9.75  ? 105 SER A N   1 
ATOM   892  C  CA  . SER A 1 105 ? 31.442 14.938  46.098 1.00 9.42  ? 105 SER A CA  1 
ATOM   893  C  C   . SER A 1 105 ? 31.919 15.097  44.647 1.00 8.98  ? 105 SER A C   1 
ATOM   894  O  O   . SER A 1 105 ? 32.859 15.894  44.354 1.00 10.02 ? 105 SER A O   1 
ATOM   895  C  CB  . SER A 1 105 ? 32.031 13.696  46.759 1.00 10.90 ? 105 SER A CB  1 
ATOM   896  O  OG  . SER A 1 105 ? 31.971 12.540  45.920 1.00 16.48 ? 105 SER A OG  1 
ATOM   897  N  N   . LEU A 1 106 ? 31.225 14.456  43.710 1.00 8.82  ? 106 LEU A N   1 
ATOM   898  C  CA  . LEU A 1 106 ? 31.537 14.581  42.297 1.00 9.09  ? 106 LEU A CA  1 
ATOM   899  C  C   . LEU A 1 106 ? 31.240 16.014  41.843 1.00 9.00  ? 106 LEU A C   1 
ATOM   900  O  O   . LEU A 1 106 ? 32.011 16.623  41.112 1.00 8.56  ? 106 LEU A O   1 
ATOM   901  C  CB  . LEU A 1 106 ? 30.762 13.611  41.415 1.00 11.20 ? 106 LEU A CB  1 
ATOM   902  C  CG  . LEU A 1 106 ? 31.104 12.137  41.585 1.00 14.22 ? 106 LEU A CG  1 
ATOM   903  C  CD1 . LEU A 1 106 ? 30.257 11.322  40.624 1.00 15.70 ? 106 LEU A CD1 1 
ATOM   904  C  CD2 . LEU A 1 106 ? 32.597 11.871  41.398 1.00 15.77 ? 106 LEU A CD2 1 
ATOM   905  N  N   . ASN A 1 107 ? 30.120 16.573  42.307 1.00 8.27  ? 107 ASN A N   1 
ATOM   906  C  CA  . ASN A 1 107 ? 29.720 17.927  41.941 1.00 7.87  ? 107 ASN A CA  1 
ATOM   907  C  C   . ASN A 1 107 ? 30.762 18.933  42.441 1.00 7.15  ? 107 ASN A C   1 
ATOM   908  O  O   . ASN A 1 107 ? 31.115 19.841  41.692 1.00 7.21  ? 107 ASN A O   1 
ATOM   909  C  CB  . ASN A 1 107 ? 28.331 18.242  42.477 1.00 7.99  ? 107 ASN A CB  1 
ATOM   910  C  CG  . ASN A 1 107 ? 27.691 19.396  41.768 1.00 8.16  ? 107 ASN A CG  1 
ATOM   911  O  OD1 . ASN A 1 107 ? 27.870 19.524  40.566 1.00 9.14  ? 107 ASN A OD1 1 
ATOM   912  N  ND2 . ASN A 1 107 ? 26.951 20.169  42.521 1.00 8.96  ? 107 ASN A ND2 1 
ATOM   913  N  N   . GLN A 1 108 ? 31.214 18.780  43.686 1.00 7.76  ? 108 GLN A N   1 
ATOM   914  C  CA  . GLN A 1 108 ? 32.240 19.664  44.169 1.00 7.85  ? 108 GLN A CA  1 
ATOM   915  C  C   . GLN A 1 108 ? 33.516 19.578  43.333 1.00 7.51  ? 108 GLN A C   1 
ATOM   916  O  O   . GLN A 1 108 ? 34.164 20.591  43.048 1.00 7.68  ? 108 GLN A O   1 
ATOM   917  C  CB  . GLN A 1 108 ? 32.569 19.416  45.630 1.00 8.90  ? 108 GLN A CB  1 
ATOM   918  C  CG  . GLN A 1 108 ? 33.399 20.549  46.201 1.00 9.91  ? 108 GLN A CG  1 
ATOM   919  C  CD  . GLN A 1 108 ? 32.741 21.902  46.133 1.00 11.69 ? 108 GLN A CD  1 
ATOM   920  O  OE1 . GLN A 1 108 ? 31.625 22.110  46.629 1.00 12.40 ? 108 GLN A OE1 1 
ATOM   921  N  NE2 . GLN A 1 108 ? 33.402 22.842  45.490 1.00 12.14 ? 108 GLN A NE2 1 
ATOM   922  N  N   . ALA A 1 109 ? 33.861 18.361  42.901 1.00 7.52  ? 109 ALA A N   1 
ATOM   923  C  CA  . ALA A 1 109 ? 35.041 18.180  42.035 1.00 7.20  ? 109 ALA A CA  1 
ATOM   924  C  C   . ALA A 1 109 ? 34.850 18.893  40.700 1.00 7.68  ? 109 ALA A C   1 
ATOM   925  O  O   . ALA A 1 109 ? 35.781 19.514  40.164 1.00 7.64  ? 109 ALA A O   1 
ATOM   926  C  CB  . ALA A 1 109 ? 35.368 16.718  41.848 1.00 7.83  ? 109 ALA A CB  1 
ATOM   927  N  N   . LEU A 1 110 ? 33.642 18.798  40.128 1.00 7.32  ? 110 LEU A N   1 
ATOM   928  C  CA  . LEU A 1 110 ? 33.306 19.534  38.906 1.00 7.35  ? 110 LEU A CA  1 
ATOM   929  C  C   . LEU A 1 110 ? 33.473 21.038  39.126 1.00 7.42  ? 110 LEU A C   1 
ATOM   930  O  O   . LEU A 1 110 ? 34.019 21.735  38.256 1.00 7.64  ? 110 LEU A O   1 
ATOM   931  C  CB  . LEU A 1 110 ? 31.871 19.242  38.467 1.00 7.86  ? 110 LEU A CB  1 
ATOM   932  C  CG  . LEU A 1 110 ? 31.586 17.828  37.946 1.00 8.47  ? 110 LEU A CG  1 
ATOM   933  C  CD1 . LEU A 1 110 ? 30.121 17.692  37.796 1.00 9.00  ? 110 LEU A CD1 1 
ATOM   934  C  CD2 . LEU A 1 110 ? 32.306 17.564  36.642 1.00 9.41  ? 110 LEU A CD2 1 
ATOM   935  N  N   . LEU A 1 111 ? 32.919 21.546  40.236 1.00 7.71  ? 111 LEU A N   1 
ATOM   936  C  CA  . LEU A 1 111 ? 32.979 22.965  40.529 1.00 8.34  ? 111 LEU A CA  1 
ATOM   937  C  C   . LEU A 1 111 ? 34.421 23.428  40.736 1.00 8.91  ? 111 LEU A C   1 
ATOM   938  O  O   . LEU A 1 111 ? 34.815 24.506  40.276 1.00 8.82  ? 111 LEU A O   1 
ATOM   939  C  CB  . LEU A 1 111 ? 32.122 23.318  41.753 1.00 8.65  ? 111 LEU A CB  1 
ATOM   940  C  CG  . LEU A 1 111 ? 30.619 23.069  41.562 1.00 9.42  ? 111 LEU A CG  1 
ATOM   941  C  CD1 . LEU A 1 111 ? 29.876 23.229  42.867 1.00 10.54 ? 111 LEU A CD1 1 
ATOM   942  C  CD2 . LEU A 1 111 ? 30.094 24.021  40.471 1.00 10.06 ? 111 LEU A CD2 1 
ATOM   943  N  N   . ASP A 1 112 ? 35.229 22.609  41.402 1.00 8.17  ? 112 ASP A N   1 
ATOM   944  C  CA  . ASP A 1 112 ? 36.629 22.920  41.611 1.00 8.30  ? 112 ASP A CA  1 
ATOM   945  C  C   . ASP A 1 112 ? 37.380 22.986  40.276 1.00 8.51  ? 112 ASP A C   1 
ATOM   946  O  O   . ASP A 1 112 ? 38.211 23.906  40.082 1.00 9.19  ? 112 ASP A O   1 
ATOM   947  C  CB  . ASP A 1 112 ? 37.251 21.928  42.569 1.00 9.23  ? 112 ASP A CB  1 
ATOM   948  C  CG  . ASP A 1 112 ? 36.775 21.935  44.000 1.00 11.23 ? 112 ASP A CG  1 
ATOM   949  O  OD1 . ASP A 1 112 ? 36.120 22.882  44.380 1.00 11.16 ? 112 ASP A OD1 1 
ATOM   950  O  OD2 . ASP A 1 112 ? 37.111 20.963  44.687 1.00 13.22 ? 112 ASP A OD2 1 
ATOM   951  N  N   . LEU A 1 113 ? 37.105 22.024  39.380 1.00 8.55  ? 113 LEU A N   1 
ATOM   952  C  CA  . LEU A 1 113 ? 37.782 22.030  38.088 1.00 8.45  ? 113 LEU A CA  1 
ATOM   953  C  C   . LEU A 1 113 ? 37.315 23.248  37.296 1.00 8.56  ? 113 LEU A C   1 
ATOM   954  O  O   . LEU A 1 113 ? 38.107 23.878  36.591 1.00 9.12  ? 113 LEU A O   1 
ATOM   955  C  CB  . LEU A 1 113 ? 37.546 20.726  37.346 1.00 8.84  ? 113 LEU A CB  1 
ATOM   956  C  CG  . LEU A 1 113 ? 38.158 20.604  35.956 1.00 9.10  ? 113 LEU A CG  1 
ATOM   957  C  CD1 . LEU A 1 113 ? 39.657 20.870  36.032 1.00 9.89  ? 113 LEU A CD1 1 
ATOM   958  C  CD2 . LEU A 1 113 ? 37.830 19.212  35.399 1.00 10.13 ? 113 LEU A CD2 1 
ATOM   959  N  N   . HIS A 1 114 ? 36.032 23.601  37.349 1.00 8.34  ? 114 HIS A N   1 
ATOM   960  C  CA  . HIS A 1 114 ? 35.559 24.773  36.655 1.00 8.52  ? 114 HIS A CA  1 
ATOM   961  C  C   . HIS A 1 114 ? 36.264 26.021  37.177 1.00 8.79  ? 114 HIS A C   1 
ATOM   962  O  O   . HIS A 1 114 ? 36.660 26.880  36.369 1.00 9.21  ? 114 HIS A O   1 
ATOM   963  C  CB  . HIS A 1 114 ? 34.038 24.901  36.794 1.00 8.93  ? 114 HIS A CB  1 
ATOM   964  C  CG  . HIS A 1 114 ? 33.466 25.968  35.922 1.00 9.84  ? 114 HIS A CG  1 
ATOM   965  N  ND1 . HIS A 1 114 ? 33.602 27.327  36.180 1.00 10.83 ? 114 HIS A ND1 1 
ATOM   966  C  CD2 . HIS A 1 114 ? 32.795 25.868  34.766 1.00 9.75  ? 114 HIS A CD2 1 
ATOM   967  C  CE1 . HIS A 1 114 ? 32.975 27.977  35.198 1.00 9.77  ? 114 HIS A CE1 1 
ATOM   968  N  NE2 . HIS A 1 114 ? 32.506 27.132  34.308 1.00 9.89  ? 114 HIS A NE2 1 
ATOM   969  N  N   . ALA A 1 115 ? 36.444 26.126  38.485 1.00 9.38  ? 115 ALA A N   1 
ATOM   970  C  CA  . ALA A 1 115 ? 37.118 27.288  39.048 1.00 10.29 ? 115 ALA A CA  1 
ATOM   971  C  C   . ALA A 1 115 ? 38.565 27.342  38.584 1.00 10.33 ? 115 ALA A C   1 
ATOM   972  O  O   . ALA A 1 115 ? 39.062 28.449  38.317 1.00 11.08 ? 115 ALA A O   1 
ATOM   973  C  CB  . ALA A 1 115 ? 37.012 27.268  40.560 1.00 9.92  ? 115 ALA A CB  1 
ATOM   974  N  N   . LEU A 1 116 ? 39.225 26.183  38.503 1.00 10.17 ? 116 LEU A N   1 
ATOM   975  C  CA  . LEU A 1 116 ? 40.609 26.144  38.011 1.00 9.84  ? 116 LEU A CA  1 
ATOM   976  C  C   . LEU A 1 116 ? 40.652 26.610  36.564 1.00 10.28 ? 116 LEU A C   1 
ATOM   977  O  O   . LEU A 1 116 ? 41.498 27.430  36.167 1.00 10.82 ? 116 LEU A O   1 
ATOM   978  C  CB  . LEU A 1 116 ? 41.138 24.720  38.166 1.00 10.80 ? 116 LEU A CB  1 
ATOM   979  C  CG  . LEU A 1 116 ? 42.522 24.479  37.564 1.00 12.32 ? 116 LEU A CG  1 
ATOM   980  C  CD1 . LEU A 1 116 ? 43.586 25.333  38.237 1.00 13.17 ? 116 LEU A CD1 1 
ATOM   981  C  CD2 . LEU A 1 116 ? 42.909 23.051  37.658 1.00 12.62 ? 116 LEU A CD2 1 
ATOM   982  N  N   . GLY A 1 117 ? 39.728 26.109  35.758 1.00 10.47 ? 117 GLY A N   1 
ATOM   983  C  CA  . GLY A 1 117 ? 39.711 26.543  34.375 1.00 9.85  ? 117 GLY A CA  1 
ATOM   984  C  C   . GLY A 1 117 ? 39.447 28.024  34.206 1.00 10.90 ? 117 GLY A C   1 
ATOM   985  O  O   . GLY A 1 117 ? 40.022 28.705  33.364 1.00 11.64 ? 117 GLY A O   1 
ATOM   986  N  N   . SER A 1 118 ? 38.569 28.563  35.044 1.00 11.33 ? 118 SER A N   1 
ATOM   987  C  CA  A SER A 1 118 ? 38.297 29.975  35.007 0.69 12.52 ? 118 SER A CA  1 
ATOM   988  C  CA  B SER A 1 118 ? 38.281 29.981  35.057 0.31 11.90 ? 118 SER A CA  1 
ATOM   989  C  C   . SER A 1 118 ? 39.552 30.766  35.384 1.00 12.51 ? 118 SER A C   1 
ATOM   990  O  O   . SER A 1 118 ? 39.887 31.765  34.721 1.00 14.01 ? 118 SER A O   1 
ATOM   991  C  CB  A SER A 1 118 ? 37.147 30.326  35.916 0.69 14.85 ? 118 SER A CB  1 
ATOM   992  C  CB  B SER A 1 118 ? 37.178 30.271  36.066 0.31 12.24 ? 118 SER A CB  1 
ATOM   993  O  OG  A SER A 1 118 ? 36.843 31.696  35.704 0.69 15.78 ? 118 SER A OG  1 
ATOM   994  O  OG  B SER A 1 118 ? 35.981 29.569  35.754 0.31 12.04 ? 118 SER A OG  1 
ATOM   995  N  N   . ALA A 1 119 ? 40.223 30.358  36.446 1.00 12.28 ? 119 ALA A N   1 
ATOM   996  C  CA  . ALA A 1 119 ? 41.463 31.017  36.895 1.00 13.33 ? 119 ALA A CA  1 
ATOM   997  C  C   . ALA A 1 119 ? 42.538 30.982  35.815 1.00 15.31 ? 119 ALA A C   1 
ATOM   998  O  O   . ALA A 1 119 ? 43.322 31.934  35.686 1.00 17.20 ? 119 ALA A O   1 
ATOM   999  C  CB  . ALA A 1 119 ? 41.989 30.383  38.115 1.00 14.37 ? 119 ALA A CB  1 
ATOM   1000 N  N   . GLN A 1 120 ? 42.589 29.895  35.050 1.00 12.13 ? 120 GLN A N   1 
ATOM   1001 C  CA  A GLN A 1 120 ? 43.573 29.659  33.985 0.59 11.72 ? 120 GLN A CA  1 
ATOM   1002 C  CA  B GLN A 1 120 ? 43.590 29.795  34.002 0.41 11.59 ? 120 GLN A CA  1 
ATOM   1003 C  C   . GLN A 1 120 ? 43.118 30.256  32.635 1.00 12.39 ? 120 GLN A C   1 
ATOM   1004 O  O   . GLN A 1 120 ? 43.858 30.078  31.646 1.00 13.37 ? 120 GLN A O   1 
ATOM   1005 C  CB  A GLN A 1 120 ? 43.864 28.163  33.770 0.59 12.71 ? 120 GLN A CB  1 
ATOM   1006 C  CB  B GLN A 1 120 ? 44.012 28.356  33.937 0.41 11.30 ? 120 GLN A CB  1 
ATOM   1007 C  CG  A GLN A 1 120 ? 44.578 27.402  34.893 0.59 13.94 ? 120 GLN A CG  1 
ATOM   1008 C  CG  B GLN A 1 120 ? 44.692 27.972  35.228 0.41 11.31 ? 120 GLN A CG  1 
ATOM   1009 C  CD  A GLN A 1 120 ? 46.060 27.673  35.025 0.59 15.19 ? 120 GLN A CD  1 
ATOM   1010 C  CD  B GLN A 1 120 ? 45.301 26.628  35.017 0.41 11.15 ? 120 GLN A CD  1 
ATOM   1011 O  OE1 A GLN A 1 120 ? 46.734 28.007  34.049 0.59 16.91 ? 120 GLN A OE1 1 
ATOM   1012 O  OE1 B GLN A 1 120 ? 44.804 25.893  34.169 0.41 13.15 ? 120 GLN A OE1 1 
ATOM   1013 N  NE2 A GLN A 1 120 ? 46.585 27.519  36.233 0.59 18.18 ? 120 GLN A NE2 1 
ATOM   1014 N  NE2 B GLN A 1 120 ? 46.505 26.438  35.520 0.41 11.76 ? 120 GLN A NE2 1 
ATOM   1015 N  N   . ALA A 1 121 ? 41.964 30.907  32.564 1.00 11.38 ? 121 ALA A N   1 
ATOM   1016 C  CA  . ALA A 1 121 ? 41.389 31.440  31.351 1.00 10.38 ? 121 ALA A CA  1 
ATOM   1017 C  C   . ALA A 1 121 ? 41.378 30.355  30.281 1.00 9.53  ? 121 ALA A C   1 
ATOM   1018 O  O   . ALA A 1 121 ? 41.863 30.564  29.166 1.00 9.05  ? 121 ALA A O   1 
ATOM   1019 C  CB  . ALA A 1 121 ? 42.149 32.680  30.888 1.00 12.30 ? 121 ALA A CB  1 
ATOM   1020 N  N   . ASP A 1 122 ? 40.721 29.239  30.644 1.00 8.07  ? 122 ASP A N   1 
ATOM   1021 C  CA  . ASP A 1 122 ? 40.518 28.096  29.766 1.00 8.07  ? 122 ASP A CA  1 
ATOM   1022 C  C   . ASP A 1 122 ? 39.034 27.955  29.454 1.00 7.84  ? 122 ASP A C   1 
ATOM   1023 O  O   . ASP A 1 122 ? 38.299 27.182  30.082 1.00 8.00  ? 122 ASP A O   1 
ATOM   1024 C  CB  . ASP A 1 122 ? 41.060 26.825  30.391 1.00 7.75  ? 122 ASP A CB  1 
ATOM   1025 C  CG  . ASP A 1 122 ? 41.135 25.645  29.439 1.00 7.61  ? 122 ASP A CG  1 
ATOM   1026 O  OD1 . ASP A 1 122 ? 40.406 25.657  28.432 1.00 8.15  ? 122 ASP A OD1 1 
ATOM   1027 O  OD2 . ASP A 1 122 ? 41.909 24.734  29.753 1.00 8.37  ? 122 ASP A OD2 1 
ATOM   1028 N  N   . PRO A 1 123 ? 38.466 28.759  28.532 1.00 7.48  ? 123 PRO A N   1 
ATOM   1029 C  CA  . PRO A 1 123 ? 37.031 28.743  28.327 1.00 7.91  ? 123 PRO A CA  1 
ATOM   1030 C  C   . PRO A 1 123 ? 36.522 27.463  27.702 1.00 7.69  ? 123 PRO A C   1 
ATOM   1031 O  O   . PRO A 1 123 ? 35.361 27.131  27.875 1.00 9.12  ? 123 PRO A O   1 
ATOM   1032 C  CB  . PRO A 1 123 ? 36.788 29.982  27.419 1.00 8.29  ? 123 PRO A CB  1 
ATOM   1033 C  CG  . PRO A 1 123 ? 38.115 30.199  26.741 1.00 8.90  ? 123 PRO A CG  1 
ATOM   1034 C  CD  . PRO A 1 123 ? 39.151 29.846  27.803 1.00 8.13  ? 123 PRO A CD  1 
ATOM   1035 N  N   . HIS A 1 124 ? 37.351 26.764  26.936 1.00 7.39  ? 124 HIS A N   1 
ATOM   1036 C  CA  . HIS A 1 124 ? 36.880 25.497  26.359 1.00 7.40  ? 124 HIS A CA  1 
ATOM   1037 C  C   . HIS A 1 124 ? 36.571 24.530  27.529 1.00 7.66  ? 124 HIS A C   1 
ATOM   1038 O  O   . HIS A 1 124 ? 35.531 23.849  27.508 1.00 8.23  ? 124 HIS A O   1 
ATOM   1039 C  CB  . HIS A 1 124 ? 37.859 24.907  25.377 1.00 7.82  ? 124 HIS A CB  1 
ATOM   1040 C  CG  . HIS A 1 124 ? 37.361 23.650  24.782 1.00 8.85  ? 124 HIS A CG  1 
ATOM   1041 N  ND1 . HIS A 1 124 ? 37.512 22.421  25.379 1.00 9.24  ? 124 HIS A ND1 1 
ATOM   1042 C  CD2 . HIS A 1 124 ? 36.671 23.424  23.625 1.00 10.12 ? 124 HIS A CD2 1 
ATOM   1043 C  CE1 . HIS A 1 124 ? 36.906 21.496  24.605 1.00 9.59  ? 124 HIS A CE1 1 
ATOM   1044 N  NE2 . HIS A 1 124 ? 36.388 22.076  23.527 1.00 10.54 ? 124 HIS A NE2 1 
ATOM   1045 N  N   . LEU A 1 125 ? 37.463 24.463  28.509 1.00 7.72  ? 125 LEU A N   1 
ATOM   1046 C  CA  A LEU A 1 125 ? 37.245 23.567  29.637 0.43 7.76  ? 125 LEU A CA  1 
ATOM   1047 C  CA  B LEU A 1 125 ? 37.263 23.577  29.656 0.57 7.92  ? 125 LEU A CA  1 
ATOM   1048 C  C   . LEU A 1 125 ? 35.981 23.970  30.377 1.00 8.46  ? 125 LEU A C   1 
ATOM   1049 O  O   . LEU A 1 125 ? 35.152 23.125  30.700 1.00 8.02  ? 125 LEU A O   1 
ATOM   1050 C  CB  A LEU A 1 125 ? 38.451 23.549  30.570 0.43 7.50  ? 125 LEU A CB  1 
ATOM   1051 C  CB  B LEU A 1 125 ? 38.525 23.629  30.532 0.57 7.90  ? 125 LEU A CB  1 
ATOM   1052 C  CG  A LEU A 1 125 ? 38.257 22.702  31.831 0.43 7.64  ? 125 LEU A CG  1 
ATOM   1053 C  CG  B LEU A 1 125 ? 38.537 22.820  31.839 0.57 8.61  ? 125 LEU A CG  1 
ATOM   1054 C  CD1 A LEU A 1 125 ? 38.506 21.268  31.418 0.43 7.56  ? 125 LEU A CD1 1 
ATOM   1055 C  CD1 B LEU A 1 125 ? 37.664 23.410  32.924 0.57 9.03  ? 125 LEU A CD1 1 
ATOM   1056 C  CD2 A LEU A 1 125 ? 39.168 23.116  32.953 0.43 7.78  ? 125 LEU A CD2 1 
ATOM   1057 C  CD2 B LEU A 1 125 ? 38.165 21.375  31.527 0.57 8.70  ? 125 LEU A CD2 1 
ATOM   1058 N  N   . CYS A 1 126 ? 35.840 25.250  30.648 1.00 8.92  ? 126 CYS A N   1 
ATOM   1059 C  CA  . CYS A 1 126 ? 34.679 25.723  31.392 1.00 9.87  ? 126 CYS A CA  1 
ATOM   1060 C  C   . CYS A 1 126 ? 33.406 25.394  30.651 1.00 10.53 ? 126 CYS A C   1 
ATOM   1061 O  O   . CYS A 1 126 ? 32.476 24.856  31.285 1.00 11.48 ? 126 CYS A O   1 
ATOM   1062 C  CB  . CYS A 1 126 ? 34.821 27.202  31.695 1.00 10.56 ? 126 CYS A CB  1 
ATOM   1063 S  SG  . CYS A 1 126 ? 36.133 27.600  32.858 1.00 12.38 ? 126 CYS A SG  1 
ATOM   1064 N  N   . ASP A 1 127 ? 33.344 25.683  29.352 1.00 11.05 ? 127 ASP A N   1 
ATOM   1065 C  CA  . ASP A 1 127 ? 32.165 25.345  28.529 1.00 12.15 ? 127 ASP A CA  1 
ATOM   1066 C  C   . ASP A 1 127 ? 31.909 23.836  28.496 1.00 11.23 ? 127 ASP A C   1 
ATOM   1067 O  O   . ASP A 1 127 ? 30.754 23.419  28.557 1.00 11.55 ? 127 ASP A O   1 
ATOM   1068 C  CB  . ASP A 1 127 ? 32.243 25.839  27.089 1.00 14.99 ? 127 ASP A CB  1 
ATOM   1069 C  CG  . ASP A 1 127 ? 31.253 25.265  26.049 1.00 16.70 ? 127 ASP A CG  1 
ATOM   1070 O  OD1 . ASP A 1 127 ? 30.193 25.752  25.988 1.00 20.20 ? 127 ASP A OD1 1 
ATOM   1071 O  OD2 . ASP A 1 127 ? 31.548 24.282  25.341 1.00 24.05 ? 127 ASP A OD2 1 
ATOM   1072 N  N   . PHE A 1 128 ? 32.964 23.015  28.407 1.00 9.65  ? 128 PHE A N   1 
ATOM   1073 C  CA  . PHE A 1 128 ? 32.797 21.572  28.366 1.00 8.51  ? 128 PHE A CA  1 
ATOM   1074 C  C   . PHE A 1 128 ? 32.080 21.101  29.629 1.00 8.77  ? 128 PHE A C   1 
ATOM   1075 O  O   . PHE A 1 128 ? 31.159 20.288  29.569 1.00 8.01  ? 128 PHE A O   1 
ATOM   1076 C  CB  . PHE A 1 128 ? 34.185 20.941  28.210 1.00 8.73  ? 128 PHE A CB  1 
ATOM   1077 C  CG  . PHE A 1 128 ? 34.231 19.443  28.418 1.00 9.68  ? 128 PHE A CG  1 
ATOM   1078 C  CD1 . PHE A 1 128 ? 33.934 18.565  27.376 1.00 11.89 ? 128 PHE A CD1 1 
ATOM   1079 C  CD2 . PHE A 1 128 ? 34.498 18.930  29.665 1.00 11.12 ? 128 PHE A CD2 1 
ATOM   1080 C  CE1 . PHE A 1 128 ? 33.955 17.191  27.599 1.00 10.87 ? 128 PHE A CE1 1 
ATOM   1081 C  CE2 . PHE A 1 128 ? 34.530 17.562  29.864 1.00 13.43 ? 128 PHE A CE2 1 
ATOM   1082 C  CZ  . PHE A 1 128 ? 34.268 16.711  28.829 1.00 11.72 ? 128 PHE A CZ  1 
ATOM   1083 N  N   . LEU A 1 129 ? 32.498 21.595  30.792 1.00 7.92  ? 129 LEU A N   1 
ATOM   1084 C  CA  . LEU A 1 129 ? 31.875 21.188  32.035 1.00 8.54  ? 129 LEU A CA  1 
ATOM   1085 C  C   . LEU A 1 129 ? 30.450 21.686  32.118 1.00 10.17 ? 129 LEU A C   1 
ATOM   1086 O  O   . LEU A 1 129 ? 29.561 20.955  32.545 1.00 9.67  ? 129 LEU A O   1 
ATOM   1087 C  CB  . LEU A 1 129 ? 32.729 21.697  33.196 1.00 8.78  ? 129 LEU A CB  1 
ATOM   1088 C  CG  . LEU A 1 129 ? 34.086 21.039  33.338 1.00 9.72  ? 129 LEU A CG  1 
ATOM   1089 C  CD1 . LEU A 1 129 ? 34.812 21.727  34.497 1.00 10.19 ? 129 LEU A CD1 1 
ATOM   1090 C  CD2 . LEU A 1 129 ? 34.040 19.544  33.546 1.00 11.28 ? 129 LEU A CD2 1 
ATOM   1091 N  N   . GLU A 1 130 ? 30.242 22.943  31.755 1.00 11.51 ? 130 GLU A N   1 
ATOM   1092 C  CA  . GLU A 1 130 ? 28.907 23.523  31.818 1.00 13.43 ? 130 GLU A CA  1 
ATOM   1093 C  C   . GLU A 1 130 ? 27.963 22.762  30.904 1.00 13.92 ? 130 GLU A C   1 
ATOM   1094 O  O   . GLU A 1 130 ? 26.824 22.492  31.319 1.00 16.90 ? 130 GLU A O   1 
ATOM   1095 C  CB  . GLU A 1 130 ? 29.001 24.981  31.362 1.00 13.47 ? 130 GLU A CB  1 
ATOM   1096 C  CG  . GLU A 1 130 ? 29.669 25.906  32.351 1.00 15.74 ? 130 GLU A CG  1 
ATOM   1097 C  CD  . GLU A 1 130 ? 30.115 27.206  31.700 1.00 20.33 ? 130 GLU A CD  1 
ATOM   1098 O  OE1 . GLU A 1 130 ? 29.709 27.496  30.494 1.00 21.52 ? 130 GLU A OE1 1 
ATOM   1099 O  OE2 . GLU A 1 130 ? 30.939 27.862  32.387 1.00 15.60 ? 130 GLU A OE2 1 
ATOM   1100 N  N   . SER A 1 131 ? 28.398 22.464  29.680 1.00 13.21 ? 131 SER A N   1 
ATOM   1101 C  CA  . SER A 1 131 ? 27.552 21.865  28.646 1.00 15.16 ? 131 SER A CA  1 
ATOM   1102 C  C   . SER A 1 131 ? 27.264 20.385  28.845 1.00 15.49 ? 131 SER A C   1 
ATOM   1103 O  O   . SER A 1 131 ? 26.169 19.940  28.480 1.00 17.24 ? 131 SER A O   1 
ATOM   1104 C  CB  . SER A 1 131 ? 28.139 22.094  27.259 1.00 19.80 ? 131 SER A CB  1 
ATOM   1105 O  OG  . SER A 1 131 ? 28.217 23.511  27.068 1.00 23.39 ? 131 SER A OG  1 
ATOM   1106 N  N   . HIS A 1 132 ? 28.179 19.615  29.452 1.00 13.11 ? 132 HIS A N   1 
ATOM   1107 C  CA  . HIS A 1 132 ? 28.009 18.184  29.520 1.00 13.67 ? 132 HIS A CA  1 
ATOM   1108 C  C   . HIS A 1 132 ? 27.921 17.629  30.946 1.00 12.71 ? 132 HIS A C   1 
ATOM   1109 O  O   . HIS A 1 132 ? 27.616 16.466  31.125 1.00 14.72 ? 132 HIS A O   1 
ATOM   1110 C  CB  . HIS A 1 132 ? 29.181 17.506  28.816 1.00 15.94 ? 132 HIS A CB  1 
ATOM   1111 C  CG  . HIS A 1 132 ? 29.247 17.945  27.409 1.00 21.12 ? 132 HIS A CG  1 
ATOM   1112 N  ND1 . HIS A 1 132 ? 28.135 17.810  26.598 1.00 24.05 ? 132 HIS A ND1 1 
ATOM   1113 C  CD2 . HIS A 1 132 ? 30.207 18.544  26.695 1.00 22.43 ? 132 HIS A CD2 1 
ATOM   1114 C  CE1 . HIS A 1 132 ? 28.454 18.292  25.388 1.00 27.46 ? 132 HIS A CE1 1 
ATOM   1115 N  NE2 . HIS A 1 132 ? 29.702 18.740  25.432 1.00 27.93 ? 132 HIS A NE2 1 
ATOM   1116 N  N   . PHE A 1 133 ? 28.265 18.406  31.995 1.00 9.72  ? 133 PHE A N   1 
ATOM   1117 C  CA  . PHE A 1 133 ? 28.362 17.860  33.343 1.00 9.68  ? 133 PHE A CA  1 
ATOM   1118 C  C   . PHE A 1 133 ? 27.517 18.619  34.371 1.00 9.35  ? 133 PHE A C   1 
ATOM   1119 O  O   . PHE A 1 133 ? 26.840 17.996  35.183 1.00 10.16 ? 133 PHE A O   1 
ATOM   1120 C  CB  . PHE A 1 133 ? 29.805 17.802  33.835 1.00 9.56  ? 133 PHE A CB  1 
ATOM   1121 C  CG  . PHE A 1 133 ? 30.606 16.711  33.130 1.00 9.84  ? 133 PHE A CG  1 
ATOM   1122 C  CD1 . PHE A 1 133 ? 31.129 16.888  31.873 1.00 10.99 ? 133 PHE A CD1 1 
ATOM   1123 C  CD2 . PHE A 1 133 ? 30.767 15.487  33.743 1.00 10.88 ? 133 PHE A CD2 1 
ATOM   1124 C  CE1 . PHE A 1 133 ? 31.755 15.834  31.231 1.00 12.01 ? 133 PHE A CE1 1 
ATOM   1125 C  CE2 . PHE A 1 133 ? 31.456 14.475  33.113 1.00 11.92 ? 133 PHE A CE2 1 
ATOM   1126 C  CZ  . PHE A 1 133 ? 31.894 14.627  31.860 1.00 10.25 ? 133 PHE A CZ  1 
ATOM   1127 N  N   . LEU A 1 134 ? 27.629 19.942  34.434 1.00 9.78  ? 134 LEU A N   1 
ATOM   1128 C  CA  . LEU A 1 134 ? 27.079 20.637  35.602 1.00 9.27  ? 134 LEU A CA  1 
ATOM   1129 C  C   . LEU A 1 134 ? 25.553 20.463  35.717 1.00 9.19  ? 134 LEU A C   1 
ATOM   1130 O  O   . LEU A 1 134 ? 25.070 20.292  36.856 1.00 8.25  ? 134 LEU A O   1 
ATOM   1131 C  CB  . LEU A 1 134 ? 27.441 22.121  35.589 1.00 10.16 ? 134 LEU A CB  1 
ATOM   1132 C  CG  . LEU A 1 134 ? 28.918 22.492  35.635 1.00 11.02 ? 134 LEU A CG  1 
ATOM   1133 C  CD1 . LEU A 1 134 ? 29.091 24.012  35.784 1.00 11.68 ? 134 LEU A CD1 1 
ATOM   1134 C  CD2 . LEU A 1 134 ? 29.627 21.763  36.701 1.00 11.82 ? 134 LEU A CD2 1 
ATOM   1135 N  N   . ASP A 1 135 ? 24.822 20.710  34.622 1.00 9.20  ? 135 ASP A N   1 
ATOM   1136 C  CA  . ASP A 1 135 ? 23.380 20.579  34.681 1.00 10.58 ? 135 ASP A CA  1 
ATOM   1137 C  C   . ASP A 1 135 ? 22.985 19.119  34.859 1.00 9.85  ? 135 ASP A C   1 
ATOM   1138 O  O   . ASP A 1 135 ? 22.034 18.820  35.589 1.00 10.57 ? 135 ASP A O   1 
ATOM   1139 C  CB  . ASP A 1 135 ? 22.689 21.218  33.493 1.00 12.72 ? 135 ASP A CB  1 
ATOM   1140 C  CG  . ASP A 1 135 ? 21.182 21.332  33.682 1.00 15.79 ? 135 ASP A CG  1 
ATOM   1141 O  OD1 . ASP A 1 135 ? 20.722 21.769  34.735 1.00 16.51 ? 135 ASP A OD1 1 
ATOM   1142 O  OD2 . ASP A 1 135 ? 20.460 20.836  32.818 1.00 22.66 ? 135 ASP A OD2 1 
ATOM   1143 N  N   . GLU A 1 136 ? 23.681 18.182  34.184 1.00 10.78 ? 136 GLU A N   1 
ATOM   1144 C  CA  . GLU A 1 136 ? 23.318 16.780  34.378 1.00 12.02 ? 136 GLU A CA  1 
ATOM   1145 C  C   . GLU A 1 136 ? 23.454 16.401  35.851 1.00 10.83 ? 136 GLU A C   1 
ATOM   1146 O  O   . GLU A 1 136 ? 22.672 15.666  36.442 1.00 11.15 ? 136 GLU A O   1 
ATOM   1147 C  CB  . GLU A 1 136 ? 24.199 15.874  33.527 1.00 16.40 ? 136 GLU A CB  1 
ATOM   1148 C  CG  . GLU A 1 136 ? 24.016 16.103  32.035 1.00 21.28 ? 136 GLU A CG  1 
ATOM   1149 C  CD  . GLU A 1 136 ? 22.686 15.657  31.490 1.00 31.30 ? 136 GLU A CD  1 
ATOM   1150 O  OE1 . GLU A 1 136 ? 22.499 14.419  31.316 1.00 39.76 ? 136 GLU A OE1 1 
ATOM   1151 O  OE2 . GLU A 1 136 ? 21.849 16.561  31.235 1.00 42.05 ? 136 GLU A OE2 1 
ATOM   1152 N  N   . GLU A 1 137 ? 24.498 16.899  36.517 1.00 9.29  ? 137 GLU A N   1 
ATOM   1153 C  CA  . GLU A 1 137 ? 24.729 16.604  37.904 1.00 8.15  ? 137 GLU A CA  1 
ATOM   1154 C  C   . GLU A 1 137 ? 23.635 17.227  38.772 1.00 8.54  ? 137 GLU A C   1 
ATOM   1155 O  O   . GLU A 1 137 ? 23.156 16.601  39.710 1.00 9.00  ? 137 GLU A O   1 
ATOM   1156 C  CB  . GLU A 1 137 ? 26.127 17.089  38.299 1.00 8.82  ? 137 GLU A CB  1 
ATOM   1157 C  CG  . GLU A 1 137 ? 26.526 16.625  39.673 1.00 9.04  ? 137 GLU A CG  1 
ATOM   1158 C  CD  . GLU A 1 137 ? 26.626 15.077  39.730 1.00 9.69  ? 137 GLU A CD  1 
ATOM   1159 O  OE1 . GLU A 1 137 ? 26.907 14.379  38.759 1.00 11.86 ? 137 GLU A OE1 1 
ATOM   1160 O  OE2 . GLU A 1 137 ? 26.308 14.629  40.832 1.00 11.86 ? 137 GLU A OE2 1 
ATOM   1161 N  N   . VAL A 1 138 ? 23.294 18.510  38.526 1.00 8.33  ? 138 VAL A N   1 
ATOM   1162 C  CA  . VAL A 1 138 ? 22.221 19.134  39.302 1.00 8.70  ? 138 VAL A CA  1 
ATOM   1163 C  C   . VAL A 1 138 ? 20.917 18.356  39.140 1.00 8.47  ? 138 VAL A C   1 
ATOM   1164 O  O   . VAL A 1 138 ? 20.234 18.128  40.146 1.00 8.97  ? 138 VAL A O   1 
ATOM   1165 C  CB  . VAL A 1 138 ? 22.057 20.623  38.930 1.00 8.38  ? 138 VAL A CB  1 
ATOM   1166 C  CG1 . VAL A 1 138 ? 20.676 21.212  39.270 1.00 8.77  ? 138 VAL A CG1 1 
ATOM   1167 C  CG2 . VAL A 1 138 ? 23.120 21.477  39.564 1.00 8.55  ? 138 VAL A CG2 1 
ATOM   1168 N  N   . LYS A 1 139 ? 20.605 17.933  37.935 1.00 8.45  ? 139 LYS A N   1 
ATOM   1169 C  CA  . LYS A 1 139 ? 19.380 17.178  37.660 1.00 10.06 ? 139 LYS A CA  1 
ATOM   1170 C  C   . LYS A 1 139 ? 19.397 15.866  38.444 1.00 9.74  ? 139 LYS A C   1 
ATOM   1171 O  O   . LYS A 1 139 ? 18.408 15.455  39.083 1.00 10.30 ? 139 LYS A O   1 
ATOM   1172 C  CB  . LYS A 1 139 ? 19.195 17.000  36.159 1.00 11.51 ? 139 LYS A CB  1 
ATOM   1173 C  CG  . LYS A 1 139 ? 18.636 18.233  35.515 1.00 16.03 ? 139 LYS A CG  1 
ATOM   1174 C  CD  . LYS A 1 139 ? 18.583 18.200  34.006 1.00 22.14 ? 139 LYS A CD  1 
ATOM   1175 C  CE  . LYS A 1 139 ? 17.712 19.313  33.452 1.00 29.03 ? 139 LYS A CE  1 
ATOM   1176 N  NZ  . LYS A 1 139 ? 17.805 20.713  33.904 1.00 30.80 ? 139 LYS A NZ  1 
ATOM   1177 N  N   . LEU A 1 140 ? 20.542 15.187  38.463 1.00 9.66  ? 140 LEU A N   1 
ATOM   1178 C  CA  . LEU A 1 140 ? 20.632 13.896  39.140 1.00 10.30 ? 140 LEU A CA  1 
ATOM   1179 C  C   . LEU A 1 140 ? 20.474 14.055  40.642 1.00 10.87 ? 140 LEU A C   1 
ATOM   1180 O  O   . LEU A 1 140 ? 19.785 13.283  41.336 1.00 11.28 ? 140 LEU A O   1 
ATOM   1181 C  CB  . LEU A 1 140 ? 21.968 13.243  38.784 1.00 11.21 ? 140 LEU A CB  1 
ATOM   1182 C  CG  . LEU A 1 140 ? 22.202 11.905  39.473 1.00 12.09 ? 140 LEU A CG  1 
ATOM   1183 C  CD1 . LEU A 1 140 ? 21.094 10.881  39.185 1.00 13.28 ? 140 LEU A CD1 1 
ATOM   1184 C  CD2 . LEU A 1 140 ? 23.561 11.361  39.034 1.00 13.02 ? 140 LEU A CD2 1 
ATOM   1185 N  N   . ILE A 1 141 ? 21.131 15.051  41.234 1.00 8.87  ? 141 ILE A N   1 
ATOM   1186 C  CA  . ILE A 1 141 ? 21.036 15.286  42.660 1.00 8.60  ? 141 ILE A CA  1 
ATOM   1187 C  C   . ILE A 1 141 ? 19.580 15.638  43.043 1.00 8.53  ? 141 ILE A C   1 
ATOM   1188 O  O   . ILE A 1 141 ? 19.093 15.196  44.091 1.00 8.90  ? 141 ILE A O   1 
ATOM   1189 C  CB  . ILE A 1 141 ? 22.080 16.328  43.131 1.00 9.39  ? 141 ILE A CB  1 
ATOM   1190 C  CG1 . ILE A 1 141 ? 23.493 15.744  42.940 1.00 9.20  ? 141 ILE A CG1 1 
ATOM   1191 C  CG2 . ILE A 1 141 ? 21.861 16.812  44.558 1.00 10.54 ? 141 ILE A CG2 1 
ATOM   1192 C  CD1 . ILE A 1 141 ? 24.588 16.751  43.056 1.00 9.26  ? 141 ILE A CD1 1 
ATOM   1193 N  N   . LYS A 1 142 ? 18.905 16.397  42.194 1.00 8.86  ? 142 LYS A N   1 
ATOM   1194 C  CA  . LYS A 1 142 ? 17.511 16.745  42.482 1.00 9.08  ? 142 LYS A CA  1 
ATOM   1195 C  C   . LYS A 1 142 ? 16.665 15.474  42.506 1.00 9.30  ? 142 LYS A C   1 
ATOM   1196 O  O   . LYS A 1 142 ? 15.809 15.314  43.400 1.00 9.58  ? 142 LYS A O   1 
ATOM   1197 C  CB  . LYS A 1 142 ? 16.989 17.761  41.466 1.00 8.32  ? 142 LYS A CB  1 
ATOM   1198 C  CG  . LYS A 1 142 ? 15.482 18.062  41.503 1.00 8.19  ? 142 LYS A CG  1 
ATOM   1199 C  CD  . LYS A 1 142 ? 14.985 18.635  42.801 1.00 8.55  ? 142 LYS A CD  1 
ATOM   1200 C  CE  . LYS A 1 142 ? 13.628 19.317  42.691 1.00 8.44  ? 142 LYS A CE  1 
ATOM   1201 N  NZ  . LYS A 1 142 ? 12.540 18.339  42.506 1.00 8.76  ? 142 LYS A NZ  1 
ATOM   1202 N  N   . LYS A 1 143 ? 16.876 14.627  41.532 1.00 9.69  ? 143 LYS A N   1 
ATOM   1203 C  CA  . LYS A 1 143 ? 16.151 13.351  41.448 1.00 11.09 ? 143 LYS A CA  1 
ATOM   1204 C  C   . LYS A 1 143 ? 16.393 12.523  42.710 1.00 10.51 ? 143 LYS A C   1 
ATOM   1205 O  O   . LYS A 1 143 ? 15.479 11.930  43.345 1.00 10.46 ? 143 LYS A O   1 
ATOM   1206 C  CB  . LYS A 1 143 ? 16.533 12.577  40.185 1.00 13.11 ? 143 LYS A CB  1 
ATOM   1207 C  CG  . LYS A 1 143 ? 15.843 11.236  40.021 1.00 17.80 ? 143 LYS A CG  1 
ATOM   1208 C  CD  . LYS A 1 143 ? 14.332 11.315  39.978 1.00 22.85 ? 143 LYS A CD  1 
ATOM   1209 C  CE  . LYS A 1 143 ? 13.837 11.899  38.728 1.00 27.29 ? 143 LYS A CE  1 
ATOM   1210 N  NZ  . LYS A 1 143 ? 12.369 11.803  38.757 1.00 29.93 ? 143 LYS A NZ  1 
ATOM   1211 N  N   . MET A 1 144 ? 17.656 12.428  43.122 1.00 10.46 ? 144 MET A N   1 
ATOM   1212 C  CA  . MET A 1 144 ? 17.979 11.660  44.298 1.00 10.79 ? 144 MET A CA  1 
ATOM   1213 C  C   . MET A 1 144 ? 17.311 12.256  45.520 1.00 10.16 ? 144 MET A C   1 
ATOM   1214 O  O   . MET A 1 144 ? 16.895 11.571  46.470 1.00 10.42 ? 144 MET A O   1 
ATOM   1215 C  CB  . MET A 1 144 ? 19.484 11.540  44.548 1.00 11.77 ? 144 MET A CB  1 
ATOM   1216 C  CG  . MET A 1 144 ? 20.139 10.675  43.570 1.00 11.24 ? 144 MET A CG  1 
ATOM   1217 S  SD  . MET A 1 144 ? 21.920 10.599  43.907 1.00 12.71 ? 144 MET A SD  1 
ATOM   1218 C  CE  . MET A 1 144 ? 22.310 9.335   42.722 1.00 12.55 ? 144 MET A CE  1 
ATOM   1219 N  N   . GLY A 1 145 ? 17.327 13.604  45.641 1.00 8.91  ? 145 GLY A N   1 
ATOM   1220 C  CA  . GLY A 1 145 ? 16.646 14.234  46.736 1.00 8.71  ? 145 GLY A CA  1 
ATOM   1221 C  C   . GLY A 1 145 ? 15.137 13.928  46.760 1.00 7.78  ? 145 GLY A C   1 
ATOM   1222 O  O   . GLY A 1 145 ? 14.604 13.658  47.846 1.00 8.28  ? 145 GLY A O   1 
ATOM   1223 N  N   . ASP A 1 146 ? 14.509 14.011  45.597 1.00 8.55  ? 146 ASP A N   1 
ATOM   1224 C  CA  . ASP A 1 146 ? 13.096 13.627  45.477 1.00 8.68  ? 146 ASP A CA  1 
ATOM   1225 C  C   . ASP A 1 146 ? 12.880 12.196  45.972 1.00 8.90  ? 146 ASP A C   1 
ATOM   1226 O  O   . ASP A 1 146 ? 11.973 11.922  46.776 1.00 8.68  ? 146 ASP A O   1 
ATOM   1227 C  CB  . ASP A 1 146 ? 12.610 13.729  44.055 1.00 8.19  ? 146 ASP A CB  1 
ATOM   1228 C  CG  . ASP A 1 146 ? 12.581 15.107  43.411 1.00 9.57  ? 146 ASP A CG  1 
ATOM   1229 O  OD1 . ASP A 1 146 ? 12.763 16.118  44.122 1.00 9.10  ? 146 ASP A OD1 1 
ATOM   1230 O  OD2 . ASP A 1 146 ? 12.404 15.142  42.176 1.00 11.41 ? 146 ASP A OD2 1 
ATOM   1231 N  N   . HIS A 1 147 ? 13.770 11.287  45.553 1.00 9.65  ? 147 HIS A N   1 
ATOM   1232 C  CA  . HIS A 1 147 ? 13.658 9.913   46.000 1.00 9.41  ? 147 HIS A CA  1 
ATOM   1233 C  C   . HIS A 1 147 ? 13.835 9.806   47.511 1.00 11.02 ? 147 HIS A C   1 
ATOM   1234 O  O   . HIS A 1 147 ? 13.074 9.108   48.198 1.00 9.82  ? 147 HIS A O   1 
ATOM   1235 C  CB  . HIS A 1 147 ? 14.682 9.017   45.279 1.00 9.17  ? 147 HIS A CB  1 
ATOM   1236 C  CG  . HIS A 1 147 ? 14.373 8.743   43.870 1.00 10.02 ? 147 HIS A CG  1 
ATOM   1237 N  ND1 . HIS A 1 147 ? 13.121 8.931   43.290 1.00 9.92  ? 147 HIS A ND1 1 
ATOM   1238 C  CD2 . HIS A 1 147 ? 15.170 8.276   42.858 1.00 10.77 ? 147 HIS A CD2 1 
ATOM   1239 C  CE1 . HIS A 1 147 ? 13.192 8.572   42.050 1.00 10.45 ? 147 HIS A CE1 1 
ATOM   1240 N  NE2 . HIS A 1 147 ? 14.446 8.114   41.772 1.00 11.31 ? 147 HIS A NE2 1 
ATOM   1241 N  N   . LEU A 1 148 ? 14.856 10.449  48.087 1.00 10.11 ? 148 LEU A N   1 
ATOM   1242 C  CA  A LEU A 1 148 ? 15.073 10.402  49.527 0.62 10.93 ? 148 LEU A CA  1 
ATOM   1243 C  CA  B LEU A 1 148 ? 15.074 10.400  49.512 0.38 11.01 ? 148 LEU A CA  1 
ATOM   1244 C  C   . LEU A 1 148 ? 13.825 10.822  50.289 1.00 10.74 ? 148 LEU A C   1 
ATOM   1245 O  O   . LEU A 1 148 ? 13.445 10.174  51.264 1.00 10.52 ? 148 LEU A O   1 
ATOM   1246 C  CB  A LEU A 1 148 ? 16.258 11.234  50.030 0.62 12.34 ? 148 LEU A CB  1 
ATOM   1247 C  CB  B LEU A 1 148 ? 16.277 11.309  49.748 0.38 12.32 ? 148 LEU A CB  1 
ATOM   1248 C  CG  A LEU A 1 148 ? 17.640 10.650  49.781 0.62 12.80 ? 148 LEU A CG  1 
ATOM   1249 C  CG  B LEU A 1 148 ? 16.967 11.095  51.085 0.38 13.07 ? 148 LEU A CG  1 
ATOM   1250 C  CD1 A LEU A 1 148 ? 18.584 11.736  50.223 0.62 12.50 ? 148 LEU A CD1 1 
ATOM   1251 C  CD1 B LEU A 1 148 ? 17.620 9.731   51.054 0.38 14.49 ? 148 LEU A CD1 1 
ATOM   1252 C  CD2 A LEU A 1 148 ? 17.979 9.401   50.558 0.62 14.45 ? 148 LEU A CD2 1 
ATOM   1253 C  CD2 B LEU A 1 148 ? 17.989 12.170  51.298 0.38 13.19 ? 148 LEU A CD2 1 
ATOM   1254 N  N   . THR A 1 149 ? 13.183 11.919  49.842 1.00 9.04  ? 149 THR A N   1 
ATOM   1255 C  CA  . THR A 1 149 ? 12.007 12.394  50.525 1.00 9.14  ? 149 THR A CA  1 
ATOM   1256 C  C   . THR A 1 149 ? 10.891 11.337  50.481 1.00 8.87  ? 149 THR A C   1 
ATOM   1257 O  O   . THR A 1 149 ? 10.198 11.132  51.490 1.00 9.67  ? 149 THR A O   1 
ATOM   1258 C  CB  . THR A 1 149 ? 11.604 13.705  49.860 1.00 8.41  ? 149 THR A CB  1 
ATOM   1259 O  OG1 . THR A 1 149 ? 12.624 14.670  50.176 1.00 8.67  ? 149 THR A OG1 1 
ATOM   1260 C  CG2 . THR A 1 149 ? 10.274 14.191  50.392 1.00 9.20  ? 149 THR A CG2 1 
ATOM   1261 N  N   . ASN A 1 150 ? 10.686 10.713  49.333 1.00 8.77  ? 150 ASN A N   1 
ATOM   1262 C  CA  . ASN A 1 150 ? 9.632  9.712   49.204 1.00 8.31  ? 150 ASN A CA  1 
ATOM   1263 C  C   . ASN A 1 150 ? 9.984  8.475   50.029 1.00 8.84  ? 150 ASN A C   1 
ATOM   1264 O  O   . ASN A 1 150 ? 9.125  7.884   50.706 1.00 8.22  ? 150 ASN A O   1 
ATOM   1265 C  CB  . ASN A 1 150 ? 9.366  9.378   47.758 1.00 8.15  ? 150 ASN A CB  1 
ATOM   1266 C  CG  . ASN A 1 150 ? 8.459  10.401  47.129 1.00 8.73  ? 150 ASN A CG  1 
ATOM   1267 O  OD1 . ASN A 1 150 ? 7.251  10.369  47.349 1.00 9.03  ? 150 ASN A OD1 1 
ATOM   1268 N  ND2 . ASN A 1 150 ? 9.075  11.361  46.468 1.00 8.90  ? 150 ASN A ND2 1 
ATOM   1269 N  N   . ILE A 1 151 ? 11.246 8.054   50.002 1.00 9.22  ? 151 ILE A N   1 
ATOM   1270 C  CA  . ILE A 1 151 ? 11.619 6.946   50.857 1.00 9.95  ? 151 ILE A CA  1 
ATOM   1271 C  C   . ILE A 1 151 ? 11.365 7.252   52.323 1.00 10.45 ? 151 ILE A C   1 
ATOM   1272 O  O   . ILE A 1 151 ? 10.805 6.406   53.057 1.00 9.99  ? 151 ILE A O   1 
ATOM   1273 C  CB  . ILE A 1 151 ? 13.097 6.584   50.568 1.00 10.30 ? 151 ILE A CB  1 
ATOM   1274 C  CG1 . ILE A 1 151 ? 13.293 6.059   49.182 1.00 10.93 ? 151 ILE A CG1 1 
ATOM   1275 C  CG2 . ILE A 1 151 ? 13.583 5.594   51.635 1.00 11.06 ? 151 ILE A CG2 1 
ATOM   1276 C  CD1 . ILE A 1 151 ? 14.727 6.123   48.698 1.00 11.83 ? 151 ILE A CD1 1 
ATOM   1277 N  N   . GLN A 1 152 ? 11.776 8.432   52.802 1.00 10.55 ? 152 GLN A N   1 
ATOM   1278 C  CA  . GLN A 1 152 ? 11.642 8.864   54.178 1.00 12.40 ? 152 GLN A CA  1 
ATOM   1279 C  C   . GLN A 1 152 ? 10.164 8.913   54.575 1.00 13.82 ? 152 GLN A C   1 
ATOM   1280 O  O   . GLN A 1 152 ? 9.795  8.462   55.654 1.00 14.94 ? 152 GLN A O   1 
ATOM   1281 C  CB  . GLN A 1 152 ? 12.289 10.236  54.361 1.00 15.39 ? 152 GLN A CB  1 
ATOM   1282 C  CG  . GLN A 1 152 ? 13.813 10.219  54.265 1.00 19.16 ? 152 GLN A CG  1 
ATOM   1283 C  CD  . GLN A 1 152 ? 14.473 11.572  54.039 1.00 23.79 ? 152 GLN A CD  1 
ATOM   1284 O  OE1 . GLN A 1 152 ? 13.926 12.506  53.428 1.00 28.39 ? 152 GLN A OE1 1 
ATOM   1285 N  NE2 . GLN A 1 152 ? 15.716 11.673  54.475 1.00 27.03 ? 152 GLN A NE2 1 
ATOM   1286 N  N   . ARG A 1 153 ? 9.324  9.423   53.678 1.00 12.92 ? 153 ARG A N   1 
ATOM   1287 C  CA  . ARG A 1 153 ? 7.897  9.500   53.928 1.00 13.84 ? 153 ARG A CA  1 
ATOM   1288 C  C   . ARG A 1 153 ? 7.316  8.120   54.186 1.00 15.80 ? 153 ARG A C   1 
ATOM   1289 O  O   . ARG A 1 153 ? 6.366  7.990   54.951 1.00 15.33 ? 153 ARG A O   1 
ATOM   1290 C  CB  . ARG A 1 153 ? 7.252  10.210  52.740 1.00 17.59 ? 153 ARG A CB  1 
ATOM   1291 C  CG  . ARG A 1 153 ? 5.770  10.498  52.810 1.00 22.18 ? 153 ARG A CG  1 
ATOM   1292 C  CD  . ARG A 1 153 ? 5.397  10.764  51.326 1.00 21.34 ? 153 ARG A CD  1 
ATOM   1293 N  NE  . ARG A 1 153 ? 5.690  12.179  51.258 1.00 16.88 ? 153 ARG A NE  1 
ATOM   1294 C  CZ  . ARG A 1 153 ? 6.340  12.977  50.412 1.00 15.05 ? 153 ARG A CZ  1 
ATOM   1295 N  NH1 . ARG A 1 153 ? 6.959  12.630  49.191 1.00 11.27 ? 153 ARG A NH1 1 
ATOM   1296 N  NH2 . ARG A 1 153 ? 6.252  14.254  50.893 1.00 16.43 ? 153 ARG A NH2 1 
ATOM   1297 N  N   . LEU A 1 154 ? 7.881  7.101   53.533 1.00 15.04 ? 154 LEU A N   1 
ATOM   1298 C  CA  . LEU A 1 154 ? 7.332  5.752   53.566 1.00 15.47 ? 154 LEU A CA  1 
ATOM   1299 C  C   . LEU A 1 154 ? 7.867  4.915   54.719 1.00 20.30 ? 154 LEU A C   1 
ATOM   1300 O  O   . LEU A 1 154 ? 7.368  3.808   54.948 1.00 21.02 ? 154 LEU A O   1 
ATOM   1301 C  CB  . LEU A 1 154 ? 7.636  5.038   52.264 1.00 14.26 ? 154 LEU A CB  1 
ATOM   1302 C  CG  . LEU A 1 154 ? 6.785  5.368   51.036 1.00 13.04 ? 154 LEU A CG  1 
ATOM   1303 C  CD1 . LEU A 1 154 ? 7.370  4.954   49.736 1.00 13.47 ? 154 LEU A CD1 1 
ATOM   1304 C  CD2 . LEU A 1 154 ? 5.361  4.766   51.210 1.00 14.83 ? 154 LEU A CD2 1 
ATOM   1305 N  N   . VAL A 1 155 ? 8.807  5.433   55.495 1.00 22.68 ? 155 VAL A N   1 
ATOM   1306 C  CA  . VAL A 1 155 ? 9.335  4.625   56.584 1.00 27.80 ? 155 VAL A CA  1 
ATOM   1307 C  C   . VAL A 1 155 ? 8.255  4.418   57.647 1.00 34.95 ? 155 VAL A C   1 
ATOM   1308 O  O   . VAL A 1 155 ? 7.877  3.272   57.947 1.00 35.93 ? 155 VAL A O   1 
ATOM   1309 C  CB  . VAL A 1 155 ? 10.599 5.188   57.222 1.00 26.68 ? 155 VAL A CB  1 
ATOM   1310 C  CG1 . VAL A 1 155 ? 11.002 4.284   58.384 1.00 29.46 ? 155 VAL A CG1 1 
ATOM   1311 C  CG2 . VAL A 1 155 ? 11.739 5.315   56.204 1.00 24.73 ? 155 VAL A CG2 1 
ATOM   1312 N  N   . GLY A 1 156 ? 7.742  5.520   58.196 1.00 34.34 ? 156 GLY A N   1 
ATOM   1313 C  CA  . GLY A 1 156 ? 6.693  5.396   59.195 1.00 44.99 ? 156 GLY A CA  1 
ATOM   1314 C  C   . GLY A 1 156 ? 7.102  4.352   60.235 1.00 43.09 ? 156 GLY A C   1 
ATOM   1315 O  O   . GLY A 1 156 ? 8.224  4.412   60.727 1.00 45.50 ? 156 GLY A O   1 
ATOM   1316 N  N   . SER A 1 157 ? 6.200  3.403   60.533 1.00 46.38 ? 157 SER A N   1 
ATOM   1317 C  CA  . SER A 1 157 ? 6.507  2.250   61.371 1.00 43.73 ? 157 SER A CA  1 
ATOM   1318 C  C   . SER A 1 157 ? 6.241  0.924   60.641 1.00 46.67 ? 157 SER A C   1 
ATOM   1319 O  O   . SER A 1 157 ? 6.159  -0.122  61.286 1.00 46.22 ? 157 SER A O   1 
ATOM   1320 N  N   . GLN A 1 158 ? 6.147  0.971   59.298 1.00 36.53 ? 158 GLN A N   1 
ATOM   1321 C  CA  . GLN A 1 158 ? 6.042  -0.219  58.459 1.00 33.16 ? 158 GLN A CA  1 
ATOM   1322 C  C   . GLN A 1 158 ? 7.124  -0.128  57.373 1.00 26.16 ? 158 GLN A C   1 
ATOM   1323 O  O   . GLN A 1 158 ? 6.815  0.142   56.193 1.00 22.45 ? 158 GLN A O   1 
ATOM   1324 C  CB  . GLN A 1 158 ? 4.655  -0.357  57.811 1.00 34.19 ? 158 GLN A CB  1 
ATOM   1325 C  CG  . GLN A 1 158 ? 3.481  -0.557  58.773 1.00 39.34 ? 158 GLN A CG  1 
ATOM   1326 C  CD  . GLN A 1 158 ? 2.165  -0.865  58.070 1.00 38.33 ? 158 GLN A CD  1 
ATOM   1327 N  N   . ALA A 1 159 ? 8.387  -0.313  57.788 1.00 23.36 ? 159 ALA A N   1 
ATOM   1328 C  CA  . ALA A 1 159 ? 9.539  -0.006  56.946 1.00 19.52 ? 159 ALA A CA  1 
ATOM   1329 C  C   . ALA A 1 159 ? 9.596  -0.927  55.731 1.00 15.12 ? 159 ALA A C   1 
ATOM   1330 O  O   . ALA A 1 159 ? 9.859  -0.483  54.633 1.00 14.11 ? 159 ALA A O   1 
ATOM   1331 C  CB  . ALA A 1 159 ? 10.812 -0.132  57.732 1.00 21.58 ? 159 ALA A CB  1 
ATOM   1332 N  N   . GLY A 1 160 ? 9.404  -2.237  55.953 1.00 13.81 ? 160 GLY A N   1 
ATOM   1333 C  CA  . GLY A 1 160 ? 9.442  -3.194  54.855 1.00 12.56 ? 160 GLY A CA  1 
ATOM   1334 C  C   . GLY A 1 160 ? 8.371  -2.914  53.780 1.00 11.71 ? 160 GLY A C   1 
ATOM   1335 O  O   . GLY A 1 160 ? 8.647  -2.911  52.598 1.00 11.15 ? 160 GLY A O   1 
ATOM   1336 N  N   . LEU A 1 161 ? 7.156  -2.625  54.219 1.00 11.44 ? 161 LEU A N   1 
ATOM   1337 C  CA  . LEU A 1 161 ? 6.065  -2.260  53.323 1.00 11.58 ? 161 LEU A CA  1 
ATOM   1338 C  C   . LEU A 1 161 ? 6.436  -1.036  52.472 1.00 9.92  ? 161 LEU A C   1 
ATOM   1339 O  O   . LEU A 1 161 ? 6.226  -1.002  51.267 1.00 10.61 ? 161 LEU A O   1 
ATOM   1340 C  CB  . LEU A 1 161 ? 4.850  -1.944  54.184 1.00 13.94 ? 161 LEU A CB  1 
ATOM   1341 C  CG  . LEU A 1 161 ? 3.640  -1.317  53.487 1.00 14.78 ? 161 LEU A CG  1 
ATOM   1342 C  CD1 . LEU A 1 161 ? 3.151  -2.283  52.431 1.00 16.20 ? 161 LEU A CD1 1 
ATOM   1343 C  CD2 . LEU A 1 161 ? 2.559  -1.014  54.535 1.00 18.76 ? 161 LEU A CD2 1 
ATOM   1344 N  N   . GLY A 1 162 ? 6.937  0.002   53.151 1.00 10.86 ? 162 GLY A N   1 
ATOM   1345 C  CA  . GLY A 1 162 ? 7.310  1.219   52.437 1.00 10.47 ? 162 GLY A CA  1 
ATOM   1346 C  C   . GLY A 1 162 ? 8.451  0.978   51.452 1.00 10.32 ? 162 GLY A C   1 
ATOM   1347 O  O   . GLY A 1 162 ? 8.436  1.504   50.349 1.00 11.15 ? 162 GLY A O   1 
ATOM   1348 N  N   . GLU A 1 163 ? 9.404  0.130   51.828 1.00 9.88  ? 163 GLU A N   1 
ATOM   1349 C  CA  . GLU A 1 163 ? 10.530 -0.132  50.935 1.00 11.16 ? 163 GLU A CA  1 
ATOM   1350 C  C   . GLU A 1 163 ? 10.107 -0.866  49.670 1.00 10.08 ? 163 GLU A C   1 
ATOM   1351 O  O   . GLU A 1 163 ? 10.473 -0.550  48.533 1.00 9.49  ? 163 GLU A O   1 
ATOM   1352 C  CB  . GLU A 1 163 ? 11.579 -0.889  51.733 1.00 12.44 ? 163 GLU A CB  1 
ATOM   1353 C  CG  . GLU A 1 163 ? 12.877 -0.981  50.966 1.00 13.47 ? 163 GLU A CG  1 
ATOM   1354 C  CD  . GLU A 1 163 ? 14.106 -1.337  51.784 1.00 14.97 ? 163 GLU A CD  1 
ATOM   1355 O  OE1 . GLU A 1 163 ? 14.000 -1.909  52.901 1.00 17.99 ? 163 GLU A OE1 1 
ATOM   1356 O  OE2 . GLU A 1 163 ? 15.172 -1.191  51.192 1.00 12.70 ? 163 GLU A OE2 1 
ATOM   1357 N  N   . TYR A 1 164 ? 9.197  -1.821  49.850 1.00 9.29  ? 164 TYR A N   1 
ATOM   1358 C  CA  . TYR A 1 164 ? 8.587  -2.505  48.722 1.00 8.54  ? 164 TYR A CA  1 
ATOM   1359 C  C   . TYR A 1 164 ? 7.835  -1.527  47.822 1.00 8.35  ? 164 TYR A C   1 
ATOM   1360 O  O   . TYR A 1 164 ? 7.952  -1.578  46.622 1.00 8.65  ? 164 TYR A O   1 
ATOM   1361 C  CB  . TYR A 1 164 ? 7.676  -3.613  49.268 1.00 8.62  ? 164 TYR A CB  1 
ATOM   1362 C  CG  . TYR A 1 164 ? 6.894  -4.344  48.199 1.00 9.28  ? 164 TYR A CG  1 
ATOM   1363 C  CD1 . TYR A 1 164 ? 7.509  -5.325  47.432 1.00 9.25  ? 164 TYR A CD1 1 
ATOM   1364 C  CD2 . TYR A 1 164 ? 5.527  -4.123  47.960 1.00 10.20 ? 164 TYR A CD2 1 
ATOM   1365 C  CE1 . TYR A 1 164 ? 6.838  -6.050  46.460 1.00 8.90  ? 164 TYR A CE1 1 
ATOM   1366 C  CE2 . TYR A 1 164 ? 4.859  -4.829  46.979 1.00 9.48  ? 164 TYR A CE2 1 
ATOM   1367 C  CZ  . TYR A 1 164 ? 5.491  -5.815  46.238 1.00 9.11  ? 164 TYR A CZ  1 
ATOM   1368 O  OH  . TYR A 1 164 ? 4.814  -6.507  45.275 1.00 9.23  ? 164 TYR A OH  1 
ATOM   1369 N  N   . LEU A 1 165 ? 6.938  -0.744  48.443 1.00 8.79  ? 165 LEU A N   1 
ATOM   1370 C  CA  . LEU A 1 165 ? 6.101  0.144   47.672 1.00 8.60  ? 165 LEU A CA  1 
ATOM   1371 C  C   . LEU A 1 165 ? 6.894  1.132   46.822 1.00 8.50  ? 165 LEU A C   1 
ATOM   1372 O  O   . LEU A 1 165 ? 6.554  1.400   45.681 1.00 8.78  ? 165 LEU A O   1 
ATOM   1373 C  CB  . LEU A 1 165 ? 5.046  0.846   48.523 1.00 9.73  ? 165 LEU A CB  1 
ATOM   1374 C  CG  . LEU A 1 165 ? 3.926  -0.077  49.013 1.00 10.61 ? 165 LEU A CG  1 
ATOM   1375 C  CD1 . LEU A 1 165 ? 3.164  0.671   50.123 1.00 11.91 ? 165 LEU A CD1 1 
ATOM   1376 C  CD2 . LEU A 1 165 ? 3.075  -0.518  47.867 1.00 11.27 ? 165 LEU A CD2 1 
ATOM   1377 N  N   . PHE A 1 166 ? 7.948  1.680   47.442 1.00 9.09  ? 166 PHE A N   1 
ATOM   1378 C  CA  . PHE A 1 166 ? 8.795  2.621   46.712 1.00 9.05  ? 166 PHE A CA  1 
ATOM   1379 C  C   . PHE A 1 166 ? 9.411  1.962   45.481 1.00 8.97  ? 166 PHE A C   1 
ATOM   1380 O  O   . PHE A 1 166 ? 9.396  2.489   44.369 1.00 8.10  ? 166 PHE A O   1 
ATOM   1381 C  CB  . PHE A 1 166 ? 9.881  3.201   47.601 1.00 9.42  ? 166 PHE A CB  1 
ATOM   1382 C  CG  . PHE A 1 166 ? 10.723 4.227   46.853 1.00 9.90  ? 166 PHE A CG  1 
ATOM   1383 C  CD1 . PHE A 1 166 ? 10.219 5.517   46.617 1.00 11.10 ? 166 PHE A CD1 1 
ATOM   1384 C  CD2 . PHE A 1 166 ? 11.989 3.909   46.394 1.00 11.12 ? 166 PHE A CD2 1 
ATOM   1385 C  CE1 . PHE A 1 166 ? 10.982 6.453   45.932 1.00 11.43 ? 166 PHE A CE1 1 
ATOM   1386 C  CE2 . PHE A 1 166 ? 12.749 4.863   45.744 1.00 10.86 ? 166 PHE A CE2 1 
ATOM   1387 C  CZ  . PHE A 1 166 ? 12.237 6.114   45.479 1.00 11.21 ? 166 PHE A CZ  1 
ATOM   1388 N  N   . GLU A 1 167 ? 9.965  0.761   45.697 1.00 7.97  ? 167 GLU A N   1 
ATOM   1389 C  CA  . GLU A 1 167 ? 10.574 0.062   44.594 1.00 8.69  ? 167 GLU A CA  1 
ATOM   1390 C  C   . GLU A 1 167 ? 9.577  -0.270  43.480 1.00 8.37  ? 167 GLU A C   1 
ATOM   1391 O  O   . GLU A 1 167 ? 9.851  -0.176  42.294 1.00 9.09  ? 167 GLU A O   1 
ATOM   1392 C  CB  . GLU A 1 167 ? 11.297 -1.181  45.109 1.00 8.68  ? 167 GLU A CB  1 
ATOM   1393 C  CG  . GLU A 1 167 ? 11.969 -1.997  44.027 1.00 8.41  ? 167 GLU A CG  1 
ATOM   1394 C  CD  . GLU A 1 167 ? 11.151 -3.051  43.311 1.00 8.85  ? 167 GLU A CD  1 
ATOM   1395 O  OE1 . GLU A 1 167 ? 10.138 -3.477  43.992 1.00 9.40  ? 167 GLU A OE1 1 
ATOM   1396 O  OE2 . GLU A 1 167 ? 11.419 -3.452  42.177 1.00 9.25  ? 167 GLU A OE2 1 
ATOM   1397 N  N   . ARG A 1 168 ? 8.355  -0.643  43.873 1.00 8.66  ? 168 ARG A N   1 
ATOM   1398 C  CA  . ARG A 1 168 ? 7.347  -1.034  42.905 1.00 8.37  ? 168 ARG A CA  1 
ATOM   1399 C  C   . ARG A 1 168 ? 6.717  0.145   42.136 1.00 8.54  ? 168 ARG A C   1 
ATOM   1400 O  O   . ARG A 1 168 ? 6.449  0.043   40.935 1.00 10.13 ? 168 ARG A O   1 
ATOM   1401 C  CB  . ARG A 1 168 ? 6.177  -1.762  43.595 1.00 8.78  ? 168 ARG A CB  1 
ATOM   1402 C  CG  . ARG A 1 168 ? 6.457  -3.161  44.115 1.00 8.65  ? 168 ARG A CG  1 
ATOM   1403 C  CD  . ARG A 1 168 ? 6.580  -4.177  43.020 1.00 9.99  ? 168 ARG A CD  1 
ATOM   1404 N  NE  . ARG A 1 168 ? 7.940  -4.285  42.447 1.00 9.98  ? 168 ARG A NE  1 
ATOM   1405 C  CZ  . ARG A 1 168 ? 8.230  -5.095  41.456 1.00 11.00 ? 168 ARG A CZ  1 
ATOM   1406 N  NH1 . ARG A 1 168 ? 7.327  -5.836  40.799 1.00 11.98 ? 168 ARG A NH1 1 
ATOM   1407 N  NH2 . ARG A 1 168 ? 9.502  -5.233  41.081 1.00 12.51 ? 168 ARG A NH2 1 
ATOM   1408 N  N   . LEU A 1 169 ? 6.495  1.250   42.874 1.00 8.87  ? 169 LEU A N   1 
ATOM   1409 C  CA  . LEU A 1 169 ? 5.657  2.314   42.339 1.00 9.43  ? 169 LEU A CA  1 
ATOM   1410 C  C   . LEU A 1 169 ? 6.420  3.559   41.882 1.00 9.95  ? 169 LEU A C   1 
ATOM   1411 O  O   . LEU A 1 169 ? 5.879  4.352   41.098 1.00 9.74  ? 169 LEU A O   1 
ATOM   1412 C  CB  . LEU A 1 169 ? 4.548  2.699   43.330 1.00 10.27 ? 169 LEU A CB  1 
ATOM   1413 C  CG  . LEU A 1 169 ? 3.560  1.599   43.758 1.00 10.53 ? 169 LEU A CG  1 
ATOM   1414 C  CD1 . LEU A 1 169 ? 2.563  2.129   44.752 1.00 11.80 ? 169 LEU A CD1 1 
ATOM   1415 C  CD2 . LEU A 1 169 ? 2.898  0.964   42.550 1.00 11.89 ? 169 LEU A CD2 1 
ATOM   1416 N  N   . THR A 1 170 ? 7.661  3.756   42.346 1.00 9.41  ? 170 THR A N   1 
ATOM   1417 C  CA  . THR A 1 170 ? 8.484  4.842   41.828 1.00 10.43 ? 170 THR A CA  1 
ATOM   1418 C  C   . THR A 1 170 ? 9.557  4.320   40.879 1.00 10.67 ? 170 THR A C   1 
ATOM   1419 O  O   . THR A 1 170 ? 9.745  4.911   39.838 1.00 11.81 ? 170 THR A O   1 
ATOM   1420 C  CB  . THR A 1 170 ? 9.134  5.608   42.967 1.00 9.88  ? 170 THR A CB  1 
ATOM   1421 O  OG1 . THR A 1 170 ? 8.103  6.285   43.697 1.00 10.53 ? 170 THR A OG1 1 
ATOM   1422 C  CG2 . THR A 1 170 ? 10.114 6.671   42.476 1.00 10.06 ? 170 THR A CG2 1 
ATOM   1423 N  N   . LEU A 1 171 ? 10.299 3.272   41.256 1.00 11.79 ? 171 LEU A N   1 
ATOM   1424 C  CA  . LEU A 1 171 ? 11.451 2.896   40.434 1.00 13.10 ? 171 LEU A CA  1 
ATOM   1425 C  C   . LEU A 1 171 ? 11.046 1.999   39.267 1.00 18.19 ? 171 LEU A C   1 
ATOM   1426 O  O   . LEU A 1 171 ? 9.977  1.414   39.264 1.00 21.85 ? 171 LEU A O   1 
ATOM   1427 C  CB  . LEU A 1 171 ? 12.497 2.260   41.335 1.00 12.11 ? 171 LEU A CB  1 
ATOM   1428 C  CG  . LEU A 1 171 ? 13.044 3.173   42.433 1.00 13.17 ? 171 LEU A CG  1 
ATOM   1429 C  CD1 . LEU A 1 171 ? 14.046 2.420   43.322 1.00 13.97 ? 171 LEU A CD1 1 
ATOM   1430 C  CD2 . LEU A 1 171 ? 13.682 4.409   41.900 1.00 12.64 ? 171 LEU A CD2 1 
ATOM   1431 N  N   . LYS A 1 172 ? 11.830 2.090   38.184 1.00 21.24 ? 172 LYS A N   1 
ATOM   1432 C  CA  . LYS A 1 172 ? 11.482 1.441   36.923 1.00 29.48 ? 172 LYS A CA  1 
ATOM   1433 C  C   . LYS A 1 172 ? 11.942 -0.011  37.011 1.00 32.36 ? 172 LYS A C   1 
ATOM   1434 O  O   . LYS A 1 172 ? 13.080 -0.277  37.409 1.00 33.48 ? 172 LYS A O   1 
ATOM   1435 C  CB  . LYS A 1 172 ? 12.101 2.190   35.734 1.00 27.59 ? 172 LYS A CB  1 
ATOM   1436 N  N   . HIS A 1 173 ? 11.038 -0.940  36.681 1.00 32.87 ? 173 HIS A N   1 
ATOM   1437 C  CA  . HIS A 1 173 ? 11.343 -2.365  36.755 1.00 35.73 ? 173 HIS A CA  1 
ATOM   1438 C  C   . HIS A 1 173 ? 10.510 -3.076  35.693 1.00 40.18 ? 173 HIS A C   1 
ATOM   1439 O  O   . HIS A 1 173 ? 9.686  -2.438  35.043 1.00 44.66 ? 173 HIS A O   1 
ATOM   1440 C  CB  . HIS A 1 173 ? 11.085 -2.923  38.165 1.00 32.11 ? 173 HIS A CB  1 
ATOM   1441 C  CG  . HIS A 1 173 ? 9.705  -2.638  38.649 1.00 30.55 ? 173 HIS A CG  1 
ATOM   1442 N  ND1 . HIS A 1 173 ? 8.641  -3.393  38.200 1.00 28.70 ? 173 HIS A ND1 1 
ATOM   1443 C  CD2 . HIS A 1 173 ? 9.198  -1.687  39.475 1.00 24.75 ? 173 HIS A CD2 1 
ATOM   1444 C  CE1 . HIS A 1 173 ? 7.510  -2.938  38.750 1.00 29.92 ? 173 HIS A CE1 1 
ATOM   1445 N  NE2 . HIS A 1 173 ? 7.816  -1.895  39.513 1.00 28.80 ? 173 HIS A NE2 1 
ATOM   1446 N  N   . ASP A 1 174 ? 10.721 -4.390  35.541 1.00 48.05 ? 174 ASP A N   1 
ATOM   1447 C  CA  . ASP A 1 174 ? 9.908  -5.201  34.643 1.00 48.49 ? 174 ASP A CA  1 
ATOM   1448 C  C   . ASP A 1 174 ? 8.505  -5.375  35.247 1.00 52.36 ? 174 ASP A C   1 
ATOM   1449 O  O   . ASP A 1 174 ? 8.398  -5.365  36.504 1.00 50.73 ? 174 ASP A O   1 
HETATM 1450 CD CD  . CD  B 2 .   ? 18.747 -7.120  39.324 0.41 14.71 ? 201 CD  A CD  1 
HETATM 1451 CD CD  . CD  C 2 .   ? 48.818 -0.000  41.540 0.45 9.77  ? 202 CD  A CD  1 
HETATM 1452 CD CD  . CD  D 2 .   ? 27.081 27.081  27.081 0.13 24.99 ? 203 CD  A CD  1 
HETATM 1453 CD CD  . CD  E 2 .   ? 29.496 29.496  29.496 0.08 17.06 ? 204 CD  A CD  1 
HETATM 1454 CD CD  . CD  F 2 .   ? 31.056 29.437  29.972 0.26 18.16 ? 205 CD  A CD  1 
HETATM 1455 CD CD  . CD  G 2 .   ? 31.166 19.897  23.569 0.23 26.63 ? 206 CD  A CD  1 
HETATM 1456 CD CD  . CD  H 2 .   ? 50.707 26.032  34.610 0.17 30.26 ? 207 CD  A CD  1 
HETATM 1457 CD CD  . CD  I 2 .   ? 16.005 -7.094  35.977 0.22 53.48 ? 208 CD  A CD  1 
HETATM 1458 S  S   . SO4 J 3 .   ? 49.757 28.138  24.561 1.00 25.04 ? 209 SO4 A S   1 
HETATM 1459 O  O1  . SO4 J 3 .   ? 51.035 28.368  25.231 1.00 26.86 ? 209 SO4 A O1  1 
HETATM 1460 O  O2  . SO4 J 3 .   ? 49.911 28.465  23.164 1.00 30.18 ? 209 SO4 A O2  1 
HETATM 1461 O  O3  . SO4 J 3 .   ? 49.416 26.783  24.701 1.00 25.58 ? 209 SO4 A O3  1 
HETATM 1462 O  O4  . SO4 J 3 .   ? 48.717 28.936  25.161 1.00 30.16 ? 209 SO4 A O4  1 
HETATM 1463 S  S   . SO4 K 3 .   ? 30.784 -2.956  55.015 0.51 21.24 ? 210 SO4 A S   1 
HETATM 1464 O  O1  . SO4 K 3 .   ? 31.931 -2.943  54.130 0.51 15.85 ? 210 SO4 A O1  1 
HETATM 1465 O  O2  . SO4 K 3 .   ? 29.645 -3.119  54.250 0.51 12.02 ? 210 SO4 A O2  1 
HETATM 1466 O  O3  . SO4 K 3 .   ? 30.905 -4.052  55.941 0.51 22.81 ? 210 SO4 A O3  1 
HETATM 1467 O  O4  . SO4 K 3 .   ? 30.724 -1.704  55.728 0.51 21.67 ? 210 SO4 A O4  1 
HETATM 1468 CL CL  . CL  L 4 .   ? 50.398 1.782   40.943 1.00 23.19 ? 211 CL  A CL  1 
HETATM 1469 C  C1  . EDO M 5 .   ? 18.083 -4.654  52.454 1.00 18.22 ? 212 EDO A C1  1 
HETATM 1470 O  O1  . EDO M 5 .   ? 17.313 -5.810  52.731 1.00 23.00 ? 212 EDO A O1  1 
HETATM 1471 C  C2  . EDO M 5 .   ? 17.182 -3.606  51.972 1.00 16.43 ? 212 EDO A C2  1 
HETATM 1472 O  O2  . EDO M 5 .   ? 16.458 -3.099  53.119 1.00 16.99 ? 212 EDO A O2  1 
HETATM 1473 C  C1  . EDO N 5 .   ? 27.359 14.245  35.372 1.00 17.66 ? 213 EDO A C1  1 
HETATM 1474 O  O1  . EDO N 5 .   ? 28.092 14.304  36.514 1.00 16.25 ? 213 EDO A O1  1 
HETATM 1475 C  C2  . EDO N 5 .   ? 26.179 13.364  35.620 1.00 18.79 ? 213 EDO A C2  1 
HETATM 1476 O  O2  . EDO N 5 .   ? 26.598 12.030  35.992 1.00 20.75 ? 213 EDO A O2  1 
HETATM 1477 C  C1  . EDO O 5 .   ? 28.263 13.235  31.652 1.00 28.20 ? 214 EDO A C1  1 
HETATM 1478 O  O1  . EDO O 5 .   ? 27.125 12.407  31.585 1.00 36.32 ? 214 EDO A O1  1 
HETATM 1479 C  C2  . EDO O 5 .   ? 28.723 13.594  30.279 1.00 31.17 ? 214 EDO A C2  1 
HETATM 1480 O  O2  . EDO O 5 .   ? 27.766 14.351  29.522 1.00 30.46 ? 214 EDO A O2  1 
HETATM 1481 C  C1  . EDO P 5 .   ? 14.343 2.392   54.108 1.00 21.73 ? 215 EDO A C1  1 
HETATM 1482 O  O1  . EDO P 5 .   ? 14.628 2.000   52.780 1.00 13.66 ? 215 EDO A O1  1 
HETATM 1483 C  C2  . EDO P 5 .   ? 13.413 1.558   54.948 1.00 24.87 ? 215 EDO A C2  1 
HETATM 1484 O  O2  . EDO P 5 .   ? 13.749 0.178   55.148 1.00 31.09 ? 215 EDO A O2  1 
HETATM 1485 O  O   . HOH Q 6 .   ? 23.830 -8.096  52.842 0.51 14.58 ? 301 HOH A O   1 
HETATM 1486 O  O   . HOH Q 6 .   ? 23.386 -9.898  51.670 1.00 34.41 ? 302 HOH A O   1 
HETATM 1487 O  O   . HOH Q 6 .   ? 53.821 16.712  14.377 1.00 33.01 ? 303 HOH A O   1 
HETATM 1488 O  O   . HOH Q 6 .   ? 35.545 18.625  23.662 1.00 30.99 ? 304 HOH A O   1 
HETATM 1489 O  O   . HOH Q 6 .   ? 49.353 15.906  22.296 1.00 18.41 ? 305 HOH A O   1 
HETATM 1490 O  O   . HOH Q 6 .   ? 34.668 16.058  23.746 0.46 26.54 ? 306 HOH A O   1 
HETATM 1491 O  O   . HOH Q 6 .   ? 46.684 30.115  24.362 1.00 16.39 ? 307 HOH A O   1 
HETATM 1492 O  O   . HOH Q 6 .   ? 29.798 4.806   52.634 1.00 30.19 ? 308 HOH A O   1 
HETATM 1493 O  O   . HOH Q 6 .   ? 20.354 0.352   58.090 1.00 25.71 ? 309 HOH A O   1 
HETATM 1494 O  O   . HOH Q 6 .   ? 33.791 23.096  25.241 1.00 15.93 ? 310 HOH A O   1 
HETATM 1495 O  O   . HOH Q 6 .   ? 8.252  8.748   44.316 1.00 16.30 ? 311 HOH A O   1 
HETATM 1496 O  O   . HOH Q 6 .   ? 25.340 -9.158  56.239 1.00 52.48 ? 312 HOH A O   1 
HETATM 1497 O  O   . HOH Q 6 .   ? 29.643 -6.078  55.020 1.00 39.44 ? 313 HOH A O   1 
HETATM 1498 O  O   . HOH Q 6 .   ? 27.816 26.193  25.130 1.00 29.09 ? 314 HOH A O   1 
HETATM 1499 O  O   . HOH Q 6 .   ? 51.013 15.649  28.418 1.00 23.21 ? 315 HOH A O   1 
HETATM 1500 O  O   . HOH Q 6 .   ? 12.665 -3.833  53.991 1.00 32.49 ? 316 HOH A O   1 
HETATM 1501 O  O   . HOH Q 6 .   ? 22.808 -10.756 53.640 0.55 16.05 ? 317 HOH A O   1 
HETATM 1502 O  O   . HOH Q 6 .   ? 32.391 -6.571  54.654 1.00 35.78 ? 318 HOH A O   1 
HETATM 1503 O  O   . HOH Q 6 .   ? 45.080 23.923  19.066 1.00 26.53 ? 319 HOH A O   1 
HETATM 1504 O  O   . HOH Q 6 .   ? 51.818 17.466  31.365 1.00 37.41 ? 320 HOH A O   1 
HETATM 1505 O  O   . HOH Q 6 .   ? 11.062 13.329  40.882 1.00 21.67 ? 321 HOH A O   1 
HETATM 1506 O  O   . HOH Q 6 .   ? 18.741 -7.773  53.674 1.00 31.83 ? 322 HOH A O   1 
HETATM 1507 O  O   . HOH Q 6 .   ? 19.037 5.254   56.850 1.00 29.45 ? 323 HOH A O   1 
HETATM 1508 O  O   . HOH Q 6 .   ? 42.229 18.182  41.137 1.00 33.99 ? 324 HOH A O   1 
HETATM 1509 O  O   . HOH Q 6 .   ? 40.078 9.304   43.139 1.00 27.16 ? 325 HOH A O   1 
HETATM 1510 O  O   . HOH Q 6 .   ? 50.711 22.834  20.079 1.00 19.44 ? 326 HOH A O   1 
HETATM 1511 O  O   . HOH Q 6 .   ? 51.074 24.669  39.635 1.00 38.74 ? 327 HOH A O   1 
HETATM 1512 O  O   . HOH Q 6 .   ? 30.217 21.209  48.676 1.00 16.20 ? 328 HOH A O   1 
HETATM 1513 O  O   . HOH Q 6 .   ? 45.849 20.007  39.092 1.00 16.39 ? 329 HOH A O   1 
HETATM 1514 O  O   . HOH Q 6 .   ? 30.046 5.344   49.100 1.00 26.53 ? 330 HOH A O   1 
HETATM 1515 O  O   . HOH Q 6 .   ? 25.668 23.807  33.316 1.00 27.38 ? 331 HOH A O   1 
HETATM 1516 O  O   . HOH Q 6 .   ? 34.931 2.552   53.744 1.00 29.66 ? 332 HOH A O   1 
HETATM 1517 O  O   . HOH Q 6 .   ? 31.614 -2.809  47.166 1.00 8.02  ? 333 HOH A O   1 
HETATM 1518 O  O   . HOH Q 6 .   ? 46.828 2.022   45.199 1.00 17.58 ? 334 HOH A O   1 
HETATM 1519 O  O   . HOH Q 6 .   ? 5.223  2.269   55.367 1.00 29.21 ? 335 HOH A O   1 
HETATM 1520 O  O   . HOH Q 6 .   ? 45.107 31.302  29.427 1.00 22.70 ? 336 HOH A O   1 
HETATM 1521 O  O   . HOH Q 6 .   ? 44.135 25.348  31.117 1.00 9.24  ? 337 HOH A O   1 
HETATM 1522 O  O   . HOH Q 6 .   ? 32.408 -5.350  47.860 1.00 8.00  ? 338 HOH A O   1 
HETATM 1523 O  O   . HOH Q 6 .   ? 16.552 -10.760 53.716 1.00 28.89 ? 339 HOH A O   1 
HETATM 1524 O  O   . HOH Q 6 .   ? 47.429 13.739  23.603 1.00 18.71 ? 340 HOH A O   1 
HETATM 1525 O  O   . HOH Q 6 .   ? 42.558 20.503  19.600 1.00 9.95  ? 341 HOH A O   1 
HETATM 1526 O  O   . HOH Q 6 .   ? 8.187  8.163   57.868 1.00 36.73 ? 342 HOH A O   1 
HETATM 1527 O  O   . HOH Q 6 .   ? 35.822 -4.785  52.869 1.00 22.10 ? 343 HOH A O   1 
HETATM 1528 O  O   . HOH Q 6 .   ? 21.601 -13.965 45.711 1.00 9.34  ? 344 HOH A O   1 
HETATM 1529 O  O   . HOH Q 6 .   ? 49.913 14.839  25.549 0.63 12.83 ? 345 HOH A O   1 
HETATM 1530 O  O   . HOH Q 6 .   ? 24.579 2.380   52.433 1.00 24.17 ? 346 HOH A O   1 
HETATM 1531 O  O   . HOH Q 6 .   ? 46.203 13.717  38.192 1.00 24.48 ? 347 HOH A O   1 
HETATM 1532 O  O   . HOH Q 6 .   ? 47.785 4.170   41.109 1.00 14.62 ? 348 HOH A O   1 
HETATM 1533 O  O   . HOH Q 6 .   ? 48.898 24.651  26.309 1.00 12.69 ? 349 HOH A O   1 
HETATM 1534 O  O   . HOH Q 6 .   ? 33.871 28.649  38.543 1.00 14.07 ? 350 HOH A O   1 
HETATM 1535 O  O   . HOH Q 6 .   ? 10.346 -6.064  44.814 1.00 10.05 ? 351 HOH A O   1 
HETATM 1536 O  O   . HOH Q 6 .   ? 34.858 2.805   44.252 0.74 11.53 ? 352 HOH A O   1 
HETATM 1537 O  O   . HOH Q 6 .   ? 47.664 6.117   29.795 1.00 9.08  ? 353 HOH A O   1 
HETATM 1538 O  O   . HOH Q 6 .   ? 35.015 16.518  45.902 1.00 21.35 ? 354 HOH A O   1 
HETATM 1539 O  O   . HOH Q 6 .   ? 38.405 30.713  39.687 1.00 20.52 ? 355 HOH A O   1 
HETATM 1540 O  O   . HOH Q 6 .   ? 35.979 4.155   48.008 0.52 17.56 ? 356 HOH A O   1 
HETATM 1541 O  O   . HOH Q 6 .   ? 19.431 -16.131 51.168 1.00 23.14 ? 357 HOH A O   1 
HETATM 1542 O  O   . HOH Q 6 .   ? 36.872 -6.598  42.190 1.00 10.69 ? 358 HOH A O   1 
HETATM 1543 O  O   . HOH Q 6 .   ? 40.347 27.240  26.203 1.00 8.00  ? 359 HOH A O   1 
HETATM 1544 O  O   . HOH Q 6 .   ? 14.788 1.800   38.357 1.00 19.28 ? 360 HOH A O   1 
HETATM 1545 O  O   . HOH Q 6 .   ? 46.218 10.367  26.129 1.00 11.97 ? 361 HOH A O   1 
HETATM 1546 O  O   . HOH Q 6 .   ? 20.508 -13.306 54.532 1.00 31.10 ? 362 HOH A O   1 
HETATM 1547 O  O   . HOH Q 6 .   ? 36.282 25.611  44.149 1.00 31.39 ? 363 HOH A O   1 
HETATM 1548 O  O   . HOH Q 6 .   ? 49.663 5.667   35.718 1.00 13.72 ? 364 HOH A O   1 
HETATM 1549 O  O   . HOH Q 6 .   ? 7.297  1.869   38.873 1.00 28.73 ? 365 HOH A O   1 
HETATM 1550 O  O   . HOH Q 6 .   ? 21.120 13.887  35.035 1.00 24.57 ? 366 HOH A O   1 
HETATM 1551 O  O   . HOH Q 6 .   ? 13.072 15.467  52.769 1.00 21.20 ? 367 HOH A O   1 
HETATM 1552 O  O   . HOH Q 6 .   ? 26.737 21.479  38.996 1.00 8.68  ? 368 HOH A O   1 
HETATM 1553 O  O   . HOH Q 6 .   ? 21.428 -12.551 39.717 1.00 12.77 ? 369 HOH A O   1 
HETATM 1554 O  O   . HOH Q 6 .   ? 42.463 8.769   35.369 1.00 12.09 ? 370 HOH A O   1 
HETATM 1555 O  O   . HOH Q 6 .   ? 44.395 22.286  23.471 1.00 7.78  ? 371 HOH A O   1 
HETATM 1556 O  O   . HOH Q 6 .   ? 17.187 2.796   56.891 1.00 17.44 ? 372 HOH A O   1 
HETATM 1557 O  O   . HOH Q 6 .   ? 24.166 5.867   54.008 1.00 15.32 ? 373 HOH A O   1 
HETATM 1558 O  O   . HOH Q 6 .   ? 28.153 11.114  33.852 1.00 18.10 ? 374 HOH A O   1 
HETATM 1559 O  O   . HOH Q 6 .   ? 27.617 -5.636  45.808 1.00 12.85 ? 375 HOH A O   1 
HETATM 1560 O  O   . HOH Q 6 .   ? 29.691 14.601  49.802 1.00 15.33 ? 376 HOH A O   1 
HETATM 1561 O  O   . HOH Q 6 .   ? 36.665 21.546  47.356 1.00 34.79 ? 377 HOH A O   1 
HETATM 1562 O  O   . HOH Q 6 .   ? 32.111 4.146   47.447 1.00 12.48 ? 378 HOH A O   1 
HETATM 1563 O  O   . HOH Q 6 .   ? 39.815 25.050  42.029 1.00 20.76 ? 379 HOH A O   1 
HETATM 1564 O  O   . HOH Q 6 .   ? 24.618 20.736  26.327 1.00 40.55 ? 380 HOH A O   1 
HETATM 1565 O  O   . HOH Q 6 .   ? 11.111 -7.764  40.534 1.00 24.95 ? 381 HOH A O   1 
HETATM 1566 O  O   . HOH Q 6 .   ? 22.726 5.633   56.290 1.00 25.05 ? 382 HOH A O   1 
HETATM 1567 O  O   . HOH Q 6 .   ? 33.083 26.679  40.256 1.00 9.80  ? 383 HOH A O   1 
HETATM 1568 O  O   . HOH Q 6 .   ? 10.447 2.234   54.475 1.00 38.19 ? 384 HOH A O   1 
HETATM 1569 O  O   . HOH Q 6 .   ? 15.941 9.898   56.610 1.00 38.92 ? 385 HOH A O   1 
HETATM 1570 O  O   . HOH Q 6 .   ? 34.104 -2.112  50.744 1.00 14.57 ? 386 HOH A O   1 
HETATM 1571 O  O   . HOH Q 6 .   ? 38.456 18.842  40.608 1.00 12.78 ? 387 HOH A O   1 
HETATM 1572 O  O   . HOH Q 6 .   ? 21.122 -5.722  54.662 1.00 44.54 ? 388 HOH A O   1 
HETATM 1573 O  O   . HOH Q 6 .   ? 3.421  4.038   39.803 1.00 30.17 ? 389 HOH A O   1 
HETATM 1574 O  O   . HOH Q 6 .   ? 43.927 33.694  37.780 1.00 42.38 ? 390 HOH A O   1 
HETATM 1575 O  O   . HOH Q 6 .   ? 15.774 15.988  38.288 1.00 16.48 ? 391 HOH A O   1 
HETATM 1576 O  O   . HOH Q 6 .   ? 12.848 0.854   48.040 1.00 13.24 ? 392 HOH A O   1 
HETATM 1577 O  O   . HOH Q 6 .   ? 11.890 18.081  39.790 1.00 26.06 ? 393 HOH A O   1 
HETATM 1578 O  O   . HOH Q 6 .   ? 28.984 7.794   49.613 1.00 14.89 ? 394 HOH A O   1 
HETATM 1579 O  O   . HOH Q 6 .   ? 38.792 21.524  27.715 1.00 8.85  ? 395 HOH A O   1 
HETATM 1580 O  O   . HOH Q 6 .   ? 37.274 15.019  18.302 1.00 28.14 ? 396 HOH A O   1 
HETATM 1581 O  O   . HOH Q 6 .   ? 13.690 15.265  39.676 1.00 18.84 ? 397 HOH A O   1 
HETATM 1582 O  O   . HOH Q 6 .   ? 47.798 29.992  27.603 1.00 48.03 ? 398 HOH A O   1 
HETATM 1583 O  O   . HOH Q 6 .   ? 10.650 10.130  43.914 1.00 14.69 ? 399 HOH A O   1 
HETATM 1584 O  O   . HOH Q 6 .   ? 14.576 7.263   39.088 1.00 20.17 ? 400 HOH A O   1 
HETATM 1585 O  O   . HOH Q 6 .   ? 5.970  9.706   57.154 1.00 41.53 ? 401 HOH A O   1 
HETATM 1586 O  O   . HOH Q 6 .   ? 44.552 5.844   42.755 0.72 16.44 ? 402 HOH A O   1 
HETATM 1587 O  O   . HOH Q 6 .   ? 25.625 16.566  26.972 1.00 43.95 ? 403 HOH A O   1 
HETATM 1588 O  O   . HOH Q 6 .   ? 26.845 -7.570  49.520 1.00 9.95  ? 404 HOH A O   1 
HETATM 1589 O  O   . HOH Q 6 .   ? 42.804 24.895  22.381 1.00 7.80  ? 405 HOH A O   1 
HETATM 1590 O  O   . HOH Q 6 .   ? 38.269 33.218  32.896 1.00 33.01 ? 406 HOH A O   1 
HETATM 1591 O  O   . HOH Q 6 .   ? 49.225 13.605  31.796 1.00 14.95 ? 407 HOH A O   1 
HETATM 1592 O  O   . HOH Q 6 .   ? 42.849 32.510  27.321 1.00 17.64 ? 408 HOH A O   1 
HETATM 1593 O  O   . HOH Q 6 .   ? 33.996 8.710   43.351 1.00 16.36 ? 409 HOH A O   1 
HETATM 1594 O  O   . HOH Q 6 .   ? 23.867 -3.942  54.738 1.00 25.94 ? 410 HOH A O   1 
HETATM 1595 O  O   . HOH Q 6 .   ? 38.552 -3.543  53.588 1.00 24.36 ? 411 HOH A O   1 
HETATM 1596 O  O   . HOH Q 6 .   ? 17.185 -4.067  55.720 1.00 30.57 ? 412 HOH A O   1 
HETATM 1597 O  O   . HOH Q 6 .   ? 34.071 10.628  45.494 1.00 31.24 ? 413 HOH A O   1 
HETATM 1598 O  O   . HOH Q 6 .   ? 51.508 17.981  25.827 1.00 28.36 ? 414 HOH A O   1 
HETATM 1599 O  O   . HOH Q 6 .   ? 11.561 9.108   57.836 0.86 34.21 ? 415 HOH A O   1 
HETATM 1600 O  O   . HOH Q 6 .   ? 24.446 14.618  51.634 1.00 41.45 ? 416 HOH A O   1 
HETATM 1601 O  O   . HOH Q 6 .   ? 40.919 5.416   43.417 1.00 18.69 ? 417 HOH A O   1 
HETATM 1602 O  O   . HOH Q 6 .   ? 50.630 20.970  37.024 1.00 31.78 ? 418 HOH A O   1 
HETATM 1603 O  O   . HOH Q 6 .   ? 12.269 -7.012  42.972 1.00 10.04 ? 419 HOH A O   1 
HETATM 1604 O  O   . HOH Q 6 .   ? 11.956 8.930   38.673 1.00 40.30 ? 420 HOH A O   1 
HETATM 1605 O  O   . HOH Q 6 .   ? 52.931 13.439  28.826 1.00 28.35 ? 421 HOH A O   1 
HETATM 1606 O  O   . HOH Q 6 .   ? 46.844 30.237  32.184 1.00 45.41 ? 422 HOH A O   1 
HETATM 1607 O  O   . HOH Q 6 .   ? 12.806 2.554   50.578 1.00 17.21 ? 423 HOH A O   1 
HETATM 1608 O  O   . HOH Q 6 .   ? 34.524 -1.796  53.448 1.00 29.10 ? 424 HOH A O   1 
HETATM 1609 O  O   . HOH Q 6 .   ? 10.847 3.541   52.440 1.00 25.33 ? 425 HOH A O   1 
HETATM 1610 O  O   . HOH Q 6 .   ? 34.007 14.505  25.040 0.75 20.57 ? 426 HOH A O   1 
HETATM 1611 O  O   . HOH Q 6 .   ? 49.661 17.297  34.051 1.00 16.42 ? 427 HOH A O   1 
HETATM 1612 O  O   . HOH Q 6 .   ? 39.839 16.665  39.824 1.00 15.33 ? 428 HOH A O   1 
HETATM 1613 O  O   . HOH Q 6 .   ? 50.809 24.629  32.264 1.00 20.54 ? 429 HOH A O   1 
HETATM 1614 O  O   . HOH Q 6 .   ? 6.395  -3.550  56.910 1.00 29.46 ? 430 HOH A O   1 
HETATM 1615 O  O   . HOH Q 6 .   ? 49.970 26.160  20.996 1.00 26.40 ? 431 HOH A O   1 
HETATM 1616 O  O   . HOH Q 6 .   ? 53.913 22.699  34.910 1.00 44.55 ? 432 HOH A O   1 
HETATM 1617 O  O   . HOH Q 6 .   ? 45.004 27.750  30.240 1.00 15.83 ? 433 HOH A O   1 
HETATM 1618 O  O   . HOH Q 6 .   ? 21.349 3.174   59.104 1.00 44.04 ? 434 HOH A O   1 
HETATM 1619 O  O   . HOH Q 6 .   ? 25.377 19.797  31.859 0.65 13.47 ? 435 HOH A O   1 
HETATM 1620 O  O   . HOH Q 6 .   ? 8.953  -0.887  60.665 1.00 47.05 ? 436 HOH A O   1 
HETATM 1621 O  O   . HOH Q 6 .   ? 35.527 4.812   45.834 0.84 20.42 ? 437 HOH A O   1 
HETATM 1622 O  O   . HOH Q 6 .   ? 33.055 6.350   44.778 0.73 14.74 ? 438 HOH A O   1 
HETATM 1623 O  O   . HOH Q 6 .   ? 38.614 18.670  43.487 1.00 21.31 ? 439 HOH A O   1 
HETATM 1624 O  O   . HOH Q 6 .   ? 39.161 11.123  47.181 1.00 41.10 ? 440 HOH A O   1 
HETATM 1625 O  O   . HOH Q 6 .   ? 47.640 13.091  35.850 1.00 24.80 ? 441 HOH A O   1 
HETATM 1626 O  O   . HOH Q 6 .   ? 8.769  -3.910  58.387 1.00 35.59 ? 442 HOH A O   1 
HETATM 1627 O  O   . HOH Q 6 .   ? 9.870  12.879  53.947 1.00 22.66 ? 443 HOH A O   1 
HETATM 1628 O  O   . HOH Q 6 .   ? 46.269 9.808   36.948 1.00 37.25 ? 444 HOH A O   1 
HETATM 1629 O  O   . HOH Q 6 .   ? 43.673 22.636  20.849 1.00 11.96 ? 445 HOH A O   1 
HETATM 1630 O  O   . HOH Q 6 .   ? 36.906 1.193   50.480 1.00 25.62 ? 446 HOH A O   1 
HETATM 1631 O  O   . HOH Q 6 .   ? 20.418 24.499  33.375 1.00 30.71 ? 447 HOH A O   1 
HETATM 1632 O  O   . HOH Q 6 .   ? 32.167 25.656  45.148 1.00 17.34 ? 448 HOH A O   1 
HETATM 1633 O  O   . HOH Q 6 .   ? 44.873 33.513  33.519 1.00 53.33 ? 449 HOH A O   1 
HETATM 1634 O  O   . HOH Q 6 .   ? 38.465 32.979  38.024 1.00 36.23 ? 450 HOH A O   1 
HETATM 1635 O  O   . HOH Q 6 .   ? 21.594 -15.245 52.026 1.00 26.75 ? 451 HOH A O   1 
HETATM 1636 O  O   . HOH Q 6 .   ? 52.876 29.325  22.544 1.00 50.47 ? 452 HOH A O   1 
HETATM 1637 O  O   . HOH Q 6 .   ? 17.008 -7.655  40.795 1.00 35.64 ? 453 HOH A O   1 
HETATM 1638 O  O   . HOH Q 6 .   ? 23.278 19.217  30.105 1.00 34.22 ? 454 HOH A O   1 
HETATM 1639 O  O   . HOH Q 6 .   ? 45.261 28.225  39.118 1.00 36.34 ? 455 HOH A O   1 
HETATM 1640 O  O   . HOH Q 6 .   ? 46.819 7.929   26.822 1.00 15.73 ? 456 HOH A O   1 
HETATM 1641 O  O   . HOH Q 6 .   ? 36.642 14.235  45.996 1.00 43.80 ? 457 HOH A O   1 
HETATM 1642 O  O   . HOH Q 6 .   ? 43.394 4.299   44.579 1.00 26.33 ? 458 HOH A O   1 
HETATM 1643 O  O   . HOH Q 6 .   ? 14.125 4.491   38.018 1.00 31.84 ? 459 HOH A O   1 
HETATM 1644 O  O   . HOH Q 6 .   ? 14.280 -8.864  43.012 0.47 14.28 ? 460 HOH A O   1 
HETATM 1645 O  O   . HOH Q 6 .   ? 30.649 17.093  48.838 1.00 29.14 ? 461 HOH A O   1 
HETATM 1646 O  O   . HOH Q 6 .   ? 51.037 23.444  27.480 1.00 33.17 ? 462 HOH A O   1 
HETATM 1647 O  O   . HOH Q 6 .   ? 48.688 14.761  34.208 1.00 23.66 ? 463 HOH A O   1 
HETATM 1648 O  O   . HOH Q 6 .   ? 9.578  12.639  43.331 0.52 14.14 ? 464 HOH A O   1 
HETATM 1649 O  O   . HOH Q 6 .   ? 44.913 11.179  38.690 1.00 32.77 ? 465 HOH A O   1 
HETATM 1650 O  O   . HOH Q 6 .   ? 41.226 27.434  41.092 1.00 30.73 ? 466 HOH A O   1 
HETATM 1651 O  O   . HOH Q 6 .   ? 25.692 8.192   53.509 1.00 22.08 ? 467 HOH A O   1 
HETATM 1652 O  O   . HOH Q 6 .   ? 34.434 14.450  17.803 1.00 44.07 ? 468 HOH A O   1 
HETATM 1653 O  O   . HOH Q 6 .   ? 45.179 -0.000  45.179 0.07 11.72 ? 469 HOH A O   1 
HETATM 1654 O  O   . HOH Q 6 .   ? 40.539 26.021  23.698 1.00 8.90  ? 470 HOH A O   1 
HETATM 1655 O  O   . HOH Q 6 .   ? 41.112 22.680  41.792 0.91 41.03 ? 471 HOH A O   1 
HETATM 1656 O  O   . HOH Q 6 .   ? 53.346 15.016  17.521 1.00 26.95 ? 472 HOH A O   1 
HETATM 1657 O  O   . HOH Q 6 .   ? 9.000  12.174  56.053 1.00 41.86 ? 473 HOH A O   1 
HETATM 1658 O  O   . HOH Q 6 .   ? 22.893 12.046  52.963 1.00 40.86 ? 474 HOH A O   1 
HETATM 1659 O  O   . HOH Q 6 .   ? 40.570 20.969  40.309 1.00 28.30 ? 475 HOH A O   1 
HETATM 1660 O  O   . HOH Q 6 .   ? 48.047 27.331  29.809 1.00 30.93 ? 476 HOH A O   1 
HETATM 1661 O  O   . HOH Q 6 .   ? 55.941 11.695  23.361 1.00 38.47 ? 477 HOH A O   1 
HETATM 1662 O  O   . HOH Q 6 .   ? 37.946 31.850  30.595 1.00 23.21 ? 478 HOH A O   1 
HETATM 1663 O  O   . HOH Q 6 .   ? 31.094 9.073   48.664 1.00 24.78 ? 479 HOH A O   1 
HETATM 1664 O  O   . HOH Q 6 .   ? 34.450 22.667  49.102 1.00 47.93 ? 480 HOH A O   1 
HETATM 1665 O  O   . HOH Q 6 .   ? 32.346 11.142  49.406 1.00 34.72 ? 481 HOH A O   1 
HETATM 1666 O  O   . HOH Q 6 .   ? 25.366 25.366  25.366 0.09 39.18 ? 482 HOH A O   1 
HETATM 1667 O  O   . HOH Q 6 .   ? 24.632 0.303   55.928 1.00 50.05 ? 483 HOH A O   1 
HETATM 1668 O  O   . HOH Q 6 .   ? 18.705 12.834  36.046 1.00 39.75 ? 484 HOH A O   1 
HETATM 1669 O  O   . HOH Q 6 .   ? 38.006 12.885  19.377 1.00 29.47 ? 485 HOH A O   1 
HETATM 1670 O  O   . HOH Q 6 .   ? 43.709 5.635   47.062 0.61 21.62 ? 486 HOH A O   1 
HETATM 1671 O  O   . HOH Q 6 .   ? 40.385 29.558  41.776 1.00 40.33 ? 487 HOH A O   1 
HETATM 1672 O  O   . HOH Q 6 .   ? 43.652 9.786   40.791 1.00 29.95 ? 488 HOH A O   1 
HETATM 1673 O  O   . HOH Q 6 .   ? 24.490 -15.814 52.252 1.00 36.73 ? 489 HOH A O   1 
HETATM 1674 O  O   . HOH Q 6 .   ? 19.746 -3.599  56.039 1.00 30.00 ? 490 HOH A O   1 
HETATM 1675 O  O   . HOH Q 6 .   ? 23.636 -2.278  56.953 1.00 50.71 ? 491 HOH A O   1 
HETATM 1676 O  O   . HOH Q 6 .   ? 20.502 -2.158  57.609 0.97 44.80 ? 492 HOH A O   1 
HETATM 1677 O  O   . HOH Q 6 .   ? 14.658 3.318   57.488 1.00 35.49 ? 493 HOH A O   1 
HETATM 1678 O  O   . HOH Q 6 .   ? 51.892 12.703  31.296 1.00 26.61 ? 494 HOH A O   1 
HETATM 1679 O  O   . HOH Q 6 .   ? 36.127 6.108   50.563 1.00 40.47 ? 495 HOH A O   1 
HETATM 1680 O  O   . HOH Q 6 .   ? 30.625 -8.569  53.617 1.00 42.30 ? 496 HOH A O   1 
HETATM 1681 O  O   . HOH Q 6 .   ? 13.681 8.757   57.013 0.96 34.00 ? 497 HOH A O   1 
HETATM 1682 O  O   . HOH Q 6 .   ? 8.373  14.472  54.427 1.00 39.21 ? 498 HOH A O   1 
HETATM 1683 O  O   . HOH Q 6 .   ? 52.184 21.214  13.821 1.00 48.15 ? 499 HOH A O   1 
HETATM 1684 O  O   . HOH Q 6 .   ? 18.889 -11.587 55.528 1.00 49.46 ? 500 HOH A O   1 
HETATM 1685 O  O   . HOH Q 6 .   ? 44.489 8.147   42.677 0.91 36.95 ? 501 HOH A O   1 
HETATM 1686 O  O   . HOH Q 6 .   ? 38.724 26.189  44.085 1.00 34.46 ? 502 HOH A O   1 
HETATM 1687 O  O   . HOH Q 6 .   ? 35.633 30.499  39.883 1.00 26.02 ? 503 HOH A O   1 
HETATM 1688 O  O   . HOH Q 6 .   ? 17.822 1.034   58.831 1.00 41.23 ? 504 HOH A O   1 
HETATM 1689 O  O   . HOH Q 6 .   ? 31.933 13.435  50.759 1.00 27.29 ? 505 HOH A O   1 
HETATM 1690 O  O   . HOH Q 6 .   ? 35.467 30.747  30.910 1.00 33.43 ? 506 HOH A O   1 
HETATM 1691 O  O   . HOH Q 6 .   ? 33.671 16.860  48.485 1.00 34.93 ? 507 HOH A O   1 
HETATM 1692 O  O   . HOH Q 6 .   ? 48.615 19.879  39.170 1.00 30.93 ? 508 HOH A O   1 
HETATM 1693 O  O   . HOH Q 6 .   ? 13.751 1.762   59.231 1.00 48.30 ? 509 HOH A O   1 
HETATM 1694 O  O   . HOH Q 6 .   ? 24.529 10.593  54.718 1.00 26.39 ? 510 HOH A O   1 
HETATM 1695 O  O   . HOH Q 6 .   ? 37.306 0.000   53.052 0.50 30.01 ? 511 HOH A O   1 
HETATM 1696 O  O   . HOH Q 6 .   ? 32.716 7.118   47.443 1.00 35.06 ? 512 HOH A O   1 
HETATM 1697 O  O   . HOH Q 6 .   ? 28.390 7.641   52.413 1.00 23.86 ? 513 HOH A O   1 
HETATM 1698 O  O   . HOH Q 6 .   ? 27.601 15.203  51.728 1.00 26.63 ? 514 HOH A O   1 
HETATM 1699 O  O   . HOH Q 6 .   ? 45.622 22.419  40.489 1.00 40.37 ? 515 HOH A O   1 
HETATM 1700 O  O   . HOH Q 6 .   ? 46.054 33.730  29.388 1.00 40.30 ? 516 HOH A O   1 
HETATM 1701 O  O   . HOH Q 6 .   ? 34.920 27.950  43.696 1.00 25.52 ? 517 HOH A O   1 
HETATM 1702 O  O   . HOH Q 6 .   ? 16.189 8.549   37.164 1.00 41.62 ? 518 HOH A O   1 
HETATM 1703 O  O   . HOH Q 6 .   ? 33.986 15.014  49.913 1.00 35.14 ? 519 HOH A O   1 
HETATM 1704 O  O   . HOH Q 6 .   ? 38.696 29.273  43.634 1.00 32.88 ? 520 HOH A O   1 
HETATM 1705 O  O   . HOH Q 6 .   ? 14.609 6.297   58.829 1.00 40.91 ? 521 HOH A O   1 
HETATM 1706 O  O   . HOH Q 6 .   ? 42.953 35.961  29.876 1.00 26.16 ? 522 HOH A O   1 
HETATM 1707 O  O   . HOH Q 6 .   ? 28.469 13.873  54.023 1.00 35.30 ? 523 HOH A O   1 
HETATM 1708 O  O   . HOH Q 6 .   ? 30.066 9.130   53.859 1.00 35.01 ? 524 HOH A O   1 
HETATM 1709 O  O   . HOH Q 6 .   ? 52.154 13.255  35.594 1.00 44.80 ? 525 HOH A O   1 
HETATM 1710 O  O   . HOH Q 6 .   ? 28.384 11.248  55.207 1.00 44.59 ? 526 HOH A O   1 
# 
