data_9KK7
# 
_entry.id   9KK7 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9KK7         pdb_00009kk7 10.2210/pdb9kk7/pdb 
WWPDB D_1300053679 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-01-29 ? 
2 'Structure model' 1 1 2025-02-19 ? 
3 'Structure model' 1 2 2025-03-12 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Database references' 
2 3 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 3 'Structure model' citation        
4 3 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.pdbx_database_id_DOI'    
2 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
3 2 'Structure model' '_citation.title'                   
4 2 'Structure model' '_citation_author.identifier_ORCID' 
5 3 'Structure model' '_citation.journal_volume'          
6 3 'Structure model' '_citation.page_first'              
7 3 'Structure model' '_citation.page_last'               
8 3 'Structure model' '_citation_author.identifier_ORCID' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9KK7 
_pdbx_database_status.recvd_initial_deposition_date   2024-11-13 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              gkurisu@protein.osaka-u.ac.jp 
_pdbx_contact_author.name_first         Genji 
_pdbx_contact_author.name_last          Kurisu 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-5354-0807 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Uenaka, M.'  1 0009-0000-4663-7582 
'Ohnishi, Y.' 2 0000-0002-1378-054X 
'Tanaka, H.'  3 0000-0003-2035-954X 
'Kurisu, G.'  4 0000-0002-5354-0807 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acta Crystallogr.,Sect.F' 
_citation.journal_id_ASTM           ACSFEN 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2053-230X 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            81 
_citation.language                  ? 
_citation.page_first                73 
_citation.page_last                 84 
_citation.title                     
;Redox-dependent hydrogen-bond network rearrangement of ferredoxin-NADP + reductase revealed by high-resolution X-ray and neutron crystallography.
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1107/S2053230X25000524 
_citation.pdbx_database_id_PubMed   39913263 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Uenaka, M.'  1 ? 
primary 'Ohnishi, Y.' 2 ? 
primary 'Ise, A.'     3 ? 
primary 'Yu, J.'      4 ? 
primary 'Yano, N.'    5 ? 
primary 'Kusaka, K.'  6 ? 
primary 'Tanaka, H.'  7 ? 
primary 'Kurisu, G.'  8 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Ferredoxin--NADP reductase, chloroplastic' 34604.191 1   1.18.1.2 ? 'UNP residues 17-327' ? 
2 non-polymer syn '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'      195.237   2   ?        ? ?                     ? 
3 non-polymer syn 'DIHYDROFLAVINE-ADENINE DINUCLEOTIDE'       787.566   1   ?        ? ?                     ? 
4 water       nat water                                       18.015    413 ?        ? ?                     ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        FNR 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SKVSVAPLHLESAKEPPLNTYKPKEPFTATIVSVESLVGPKAPGETCHIVIDHGGNVPYWEGQSYGVIPPGENPKKPGAP
QNVRLYSIASTRYGDNFDGRTGSLCVRRAVYYDPETGKEDPSKNGVCSNFLCNSKPGDKIQLTGPSGKIMLLPEEDPNAT
HIMIATGTGVAPFRGYLRRMFMEDVPNYRFGGLAWLFLGVANSDSLLYDEEFTSYLKQYPDNFRYDKALSREQKNRSGGK
MYVQDKIEEYSDEIFKLLDGGAHIYFCGLKGMMPGIQDTLKKVAERRGESWDQKLAQLKKNKQWHVEVY
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SKVSVAPLHLESAKEPPLNTYKPKEPFTATIVSVESLVGPKAPGETCHIVIDHGGNVPYWEGQSYGVIPPGENPKKPGAP
QNVRLYSIASTRYGDNFDGRTGSLCVRRAVYYDPETGKEDPSKNGVCSNFLCNSKPGDKIQLTGPSGKIMLLPEEDPNAT
HIMIATGTGVAPFRGYLRRMFMEDVPNYRFGGLAWLFLGVANSDSLLYDEEFTSYLKQYPDNFRYDKALSREQKNRSGGK
MYVQDKIEEYSDEIFKLLDGGAHIYFCGLKGMMPGIQDTLKKVAERRGESWDQKLAQLKKNKQWHVEVY
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 '2-(N-MORPHOLINO)-ETHANESULFONIC ACID' MES 
3 'DIHYDROFLAVINE-ADENINE DINUCLEOTIDE'  FDA 
4 water                                  HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   LYS n 
1 3   VAL n 
1 4   SER n 
1 5   VAL n 
1 6   ALA n 
1 7   PRO n 
1 8   LEU n 
1 9   HIS n 
1 10  LEU n 
1 11  GLU n 
1 12  SER n 
1 13  ALA n 
1 14  LYS n 
1 15  GLU n 
1 16  PRO n 
1 17  PRO n 
1 18  LEU n 
1 19  ASN n 
1 20  THR n 
1 21  TYR n 
1 22  LYS n 
1 23  PRO n 
1 24  LYS n 
1 25  GLU n 
1 26  PRO n 
1 27  PHE n 
1 28  THR n 
1 29  ALA n 
1 30  THR n 
1 31  ILE n 
1 32  VAL n 
1 33  SER n 
1 34  VAL n 
1 35  GLU n 
1 36  SER n 
1 37  LEU n 
1 38  VAL n 
1 39  GLY n 
1 40  PRO n 
1 41  LYS n 
1 42  ALA n 
1 43  PRO n 
1 44  GLY n 
1 45  GLU n 
1 46  THR n 
1 47  CYS n 
1 48  HIS n 
1 49  ILE n 
1 50  VAL n 
1 51  ILE n 
1 52  ASP n 
1 53  HIS n 
1 54  GLY n 
1 55  GLY n 
1 56  ASN n 
1 57  VAL n 
1 58  PRO n 
1 59  TYR n 
1 60  TRP n 
1 61  GLU n 
1 62  GLY n 
1 63  GLN n 
1 64  SER n 
1 65  TYR n 
1 66  GLY n 
1 67  VAL n 
1 68  ILE n 
1 69  PRO n 
1 70  PRO n 
1 71  GLY n 
1 72  GLU n 
1 73  ASN n 
1 74  PRO n 
1 75  LYS n 
1 76  LYS n 
1 77  PRO n 
1 78  GLY n 
1 79  ALA n 
1 80  PRO n 
1 81  GLN n 
1 82  ASN n 
1 83  VAL n 
1 84  ARG n 
1 85  LEU n 
1 86  TYR n 
1 87  SER n 
1 88  ILE n 
1 89  ALA n 
1 90  SER n 
1 91  THR n 
1 92  ARG n 
1 93  TYR n 
1 94  GLY n 
1 95  ASP n 
1 96  ASN n 
1 97  PHE n 
1 98  ASP n 
1 99  GLY n 
1 100 ARG n 
1 101 THR n 
1 102 GLY n 
1 103 SER n 
1 104 LEU n 
1 105 CYS n 
1 106 VAL n 
1 107 ARG n 
1 108 ARG n 
1 109 ALA n 
1 110 VAL n 
1 111 TYR n 
1 112 TYR n 
1 113 ASP n 
1 114 PRO n 
1 115 GLU n 
1 116 THR n 
1 117 GLY n 
1 118 LYS n 
1 119 GLU n 
1 120 ASP n 
1 121 PRO n 
1 122 SER n 
1 123 LYS n 
1 124 ASN n 
1 125 GLY n 
1 126 VAL n 
1 127 CYS n 
1 128 SER n 
1 129 ASN n 
1 130 PHE n 
1 131 LEU n 
1 132 CYS n 
1 133 ASN n 
1 134 SER n 
1 135 LYS n 
1 136 PRO n 
1 137 GLY n 
1 138 ASP n 
1 139 LYS n 
1 140 ILE n 
1 141 GLN n 
1 142 LEU n 
1 143 THR n 
1 144 GLY n 
1 145 PRO n 
1 146 SER n 
1 147 GLY n 
1 148 LYS n 
1 149 ILE n 
1 150 MET n 
1 151 LEU n 
1 152 LEU n 
1 153 PRO n 
1 154 GLU n 
1 155 GLU n 
1 156 ASP n 
1 157 PRO n 
1 158 ASN n 
1 159 ALA n 
1 160 THR n 
1 161 HIS n 
1 162 ILE n 
1 163 MET n 
1 164 ILE n 
1 165 ALA n 
1 166 THR n 
1 167 GLY n 
1 168 THR n 
1 169 GLY n 
1 170 VAL n 
1 171 ALA n 
1 172 PRO n 
1 173 PHE n 
1 174 ARG n 
1 175 GLY n 
1 176 TYR n 
1 177 LEU n 
1 178 ARG n 
1 179 ARG n 
1 180 MET n 
1 181 PHE n 
1 182 MET n 
1 183 GLU n 
1 184 ASP n 
1 185 VAL n 
1 186 PRO n 
1 187 ASN n 
1 188 TYR n 
1 189 ARG n 
1 190 PHE n 
1 191 GLY n 
1 192 GLY n 
1 193 LEU n 
1 194 ALA n 
1 195 TRP n 
1 196 LEU n 
1 197 PHE n 
1 198 LEU n 
1 199 GLY n 
1 200 VAL n 
1 201 ALA n 
1 202 ASN n 
1 203 SER n 
1 204 ASP n 
1 205 SER n 
1 206 LEU n 
1 207 LEU n 
1 208 TYR n 
1 209 ASP n 
1 210 GLU n 
1 211 GLU n 
1 212 PHE n 
1 213 THR n 
1 214 SER n 
1 215 TYR n 
1 216 LEU n 
1 217 LYS n 
1 218 GLN n 
1 219 TYR n 
1 220 PRO n 
1 221 ASP n 
1 222 ASN n 
1 223 PHE n 
1 224 ARG n 
1 225 TYR n 
1 226 ASP n 
1 227 LYS n 
1 228 ALA n 
1 229 LEU n 
1 230 SER n 
1 231 ARG n 
1 232 GLU n 
1 233 GLN n 
1 234 LYS n 
1 235 ASN n 
1 236 ARG n 
1 237 SER n 
1 238 GLY n 
1 239 GLY n 
1 240 LYS n 
1 241 MET n 
1 242 TYR n 
1 243 VAL n 
1 244 GLN n 
1 245 ASP n 
1 246 LYS n 
1 247 ILE n 
1 248 GLU n 
1 249 GLU n 
1 250 TYR n 
1 251 SER n 
1 252 ASP n 
1 253 GLU n 
1 254 ILE n 
1 255 PHE n 
1 256 LYS n 
1 257 LEU n 
1 258 LEU n 
1 259 ASP n 
1 260 GLY n 
1 261 GLY n 
1 262 ALA n 
1 263 HIS n 
1 264 ILE n 
1 265 TYR n 
1 266 PHE n 
1 267 CYS n 
1 268 GLY n 
1 269 LEU n 
1 270 LYS n 
1 271 GLY n 
1 272 MET n 
1 273 MET n 
1 274 PRO n 
1 275 GLY n 
1 276 ILE n 
1 277 GLN n 
1 278 ASP n 
1 279 THR n 
1 280 LEU n 
1 281 LYS n 
1 282 LYS n 
1 283 VAL n 
1 284 ALA n 
1 285 GLU n 
1 286 ARG n 
1 287 ARG n 
1 288 GLY n 
1 289 GLU n 
1 290 SER n 
1 291 TRP n 
1 292 ASP n 
1 293 GLN n 
1 294 LYS n 
1 295 LEU n 
1 296 ALA n 
1 297 GLN n 
1 298 LEU n 
1 299 LYS n 
1 300 LYS n 
1 301 ASN n 
1 302 LYS n 
1 303 GLN n 
1 304 TRP n 
1 305 HIS n 
1 306 VAL n 
1 307 GLU n 
1 308 VAL n 
1 309 TYR n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   309 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 '542713, ZEAMMB73_Zm00001d034345' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Zea mays' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     4577 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                ? 'C3 H7 N O2'        89.093  
ARG 'L-peptide linking' y ARGININE                               ? 'C6 H15 N4 O2 1'    175.209 
ASN 'L-peptide linking' y ASPARAGINE                             ? 'C4 H8 N2 O3'       132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                        ? 'C4 H7 N O4'        133.103 
CYS 'L-peptide linking' y CYSTEINE                               ? 'C3 H7 N O2 S'      121.158 
FDA non-polymer         . 'DIHYDROFLAVINE-ADENINE DINUCLEOTIDE'  ? 'C27 H35 N9 O15 P2' 787.566 
GLN 'L-peptide linking' y GLUTAMINE                              ? 'C5 H10 N2 O3'      146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                        ? 'C5 H9 N O4'        147.129 
GLY 'peptide linking'   y GLYCINE                                ? 'C2 H5 N O2'        75.067  
HIS 'L-peptide linking' y HISTIDINE                              ? 'C6 H10 N3 O2 1'    156.162 
HOH non-polymer         . WATER                                  ? 'H2 O'              18.015  
ILE 'L-peptide linking' y ISOLEUCINE                             ? 'C6 H13 N O2'       131.173 
LEU 'L-peptide linking' y LEUCINE                                ? 'C6 H13 N O2'       131.173 
LYS 'L-peptide linking' y LYSINE                                 ? 'C6 H15 N2 O2 1'    147.195 
MES non-polymer         . '2-(N-MORPHOLINO)-ETHANESULFONIC ACID' ? 'C6 H13 N O4 S'     195.237 
MET 'L-peptide linking' y METHIONINE                             ? 'C5 H11 N O2 S'     149.211 
PHE 'L-peptide linking' y PHENYLALANINE                          ? 'C9 H11 N O2'       165.189 
PRO 'L-peptide linking' y PROLINE                                ? 'C5 H9 N O2'        115.130 
SER 'L-peptide linking' y SERINE                                 ? 'C3 H7 N O3'        105.093 
THR 'L-peptide linking' y THREONINE                              ? 'C4 H9 N O3'        119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                             ? 'C11 H12 N2 O2'     204.225 
TYR 'L-peptide linking' y TYROSINE                               ? 'C9 H11 N O3'       181.189 
VAL 'L-peptide linking' y VALINE                                 ? 'C5 H11 N O2'       117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1009 1009 SER SER A . n 
A 1 2   LYS 2   1010 1010 LYS LYS A . n 
A 1 3   VAL 3   1011 1011 VAL VAL A . n 
A 1 4   SER 4   1012 1012 SER SER A . n 
A 1 5   VAL 5   1013 1013 VAL VAL A . n 
A 1 6   ALA 6   1014 1014 ALA ALA A . n 
A 1 7   PRO 7   1015 1015 PRO PRO A . n 
A 1 8   LEU 8   1016 1016 LEU LEU A . n 
A 1 9   HIS 9   1017 1017 HIS HIS A . n 
A 1 10  LEU 10  1018 1018 LEU LEU A . n 
A 1 11  GLU 11  1019 1019 GLU GLU A . n 
A 1 12  SER 12  1020 1020 SER SER A . n 
A 1 13  ALA 13  1021 1021 ALA ALA A . n 
A 1 14  LYS 14  1022 1022 LYS LYS A . n 
A 1 15  GLU 15  1023 1023 GLU GLU A . n 
A 1 16  PRO 16  1024 1024 PRO PRO A . n 
A 1 17  PRO 17  1025 1025 PRO PRO A . n 
A 1 18  LEU 18  1026 1026 LEU LEU A . n 
A 1 19  ASN 19  1027 1027 ASN ASN A . n 
A 1 20  THR 20  1028 1028 THR THR A . n 
A 1 21  TYR 21  1029 1029 TYR TYR A . n 
A 1 22  LYS 22  1030 1030 LYS LYS A . n 
A 1 23  PRO 23  1031 1031 PRO PRO A . n 
A 1 24  LYS 24  1032 1032 LYS LYS A . n 
A 1 25  GLU 25  1033 1033 GLU GLU A . n 
A 1 26  PRO 26  1034 1034 PRO PRO A . n 
A 1 27  PHE 27  1035 1035 PHE PHE A . n 
A 1 28  THR 28  1036 1036 THR THR A . n 
A 1 29  ALA 29  1037 1037 ALA ALA A . n 
A 1 30  THR 30  1038 1038 THR THR A . n 
A 1 31  ILE 31  1039 1039 ILE ILE A . n 
A 1 32  VAL 32  1040 1040 VAL VAL A . n 
A 1 33  SER 33  1041 1041 SER SER A . n 
A 1 34  VAL 34  1042 1042 VAL VAL A . n 
A 1 35  GLU 35  1043 1043 GLU GLU A . n 
A 1 36  SER 36  1044 1044 SER SER A . n 
A 1 37  LEU 37  1045 1045 LEU LEU A . n 
A 1 38  VAL 38  1046 1046 VAL VAL A . n 
A 1 39  GLY 39  1047 1047 GLY GLY A . n 
A 1 40  PRO 40  1048 1048 PRO PRO A . n 
A 1 41  LYS 41  1049 1049 LYS LYS A . n 
A 1 42  ALA 42  1050 1050 ALA ALA A . n 
A 1 43  PRO 43  1051 1051 PRO PRO A . n 
A 1 44  GLY 44  1052 1052 GLY GLY A . n 
A 1 45  GLU 45  1053 1053 GLU GLU A . n 
A 1 46  THR 46  1054 1054 THR THR A . n 
A 1 47  CYS 47  1055 1055 CYS CYS A . n 
A 1 48  HIS 48  1056 1056 HIS HIS A . n 
A 1 49  ILE 49  1057 1057 ILE ILE A . n 
A 1 50  VAL 50  1058 1058 VAL VAL A . n 
A 1 51  ILE 51  1059 1059 ILE ILE A . n 
A 1 52  ASP 52  1060 1060 ASP ASP A . n 
A 1 53  HIS 53  1061 1061 HIS HIS A . n 
A 1 54  GLY 54  1062 1062 GLY GLY A . n 
A 1 55  GLY 55  1063 1063 GLY GLY A . n 
A 1 56  ASN 56  1064 1064 ASN ASN A . n 
A 1 57  VAL 57  1065 1065 VAL VAL A . n 
A 1 58  PRO 58  1066 1066 PRO PRO A . n 
A 1 59  TYR 59  1067 1067 TYR TYR A . n 
A 1 60  TRP 60  1068 1068 TRP TRP A . n 
A 1 61  GLU 61  1069 1069 GLU GLU A . n 
A 1 62  GLY 62  1070 1070 GLY GLY A . n 
A 1 63  GLN 63  1071 1071 GLN GLN A . n 
A 1 64  SER 64  1072 1072 SER SER A . n 
A 1 65  TYR 65  1073 1073 TYR TYR A . n 
A 1 66  GLY 66  1074 1074 GLY GLY A . n 
A 1 67  VAL 67  1075 1075 VAL VAL A . n 
A 1 68  ILE 68  1076 1076 ILE ILE A . n 
A 1 69  PRO 69  1077 1077 PRO PRO A . n 
A 1 70  PRO 70  1078 1078 PRO PRO A . n 
A 1 71  GLY 71  1079 1079 GLY GLY A . n 
A 1 72  GLU 72  1080 1080 GLU GLU A . n 
A 1 73  ASN 73  1081 1081 ASN ASN A . n 
A 1 74  PRO 74  1082 1082 PRO PRO A . n 
A 1 75  LYS 75  1083 1083 LYS LYS A . n 
A 1 76  LYS 76  1084 1084 LYS LYS A . n 
A 1 77  PRO 77  1085 1085 PRO PRO A . n 
A 1 78  GLY 78  1086 1086 GLY GLY A . n 
A 1 79  ALA 79  1087 1087 ALA ALA A . n 
A 1 80  PRO 80  1088 1088 PRO PRO A . n 
A 1 81  GLN 81  1089 1089 GLN GLN A . n 
A 1 82  ASN 82  1090 1090 ASN ASN A . n 
A 1 83  VAL 83  1091 1091 VAL VAL A . n 
A 1 84  ARG 84  1092 1092 ARG ARG A . n 
A 1 85  LEU 85  1093 1093 LEU LEU A . n 
A 1 86  TYR 86  1094 1094 TYR TYR A . n 
A 1 87  SER 87  1095 1095 SER SER A . n 
A 1 88  ILE 88  1096 1096 ILE ILE A . n 
A 1 89  ALA 89  1097 1097 ALA ALA A . n 
A 1 90  SER 90  1098 1098 SER SER A . n 
A 1 91  THR 91  1099 1099 THR THR A . n 
A 1 92  ARG 92  1100 1100 ARG ARG A . n 
A 1 93  TYR 93  1101 1101 TYR TYR A . n 
A 1 94  GLY 94  1102 1102 GLY GLY A . n 
A 1 95  ASP 95  1103 1103 ASP ASP A . n 
A 1 96  ASN 96  1104 1104 ASN ASN A . n 
A 1 97  PHE 97  1105 1105 PHE PHE A . n 
A 1 98  ASP 98  1106 1106 ASP ASP A . n 
A 1 99  GLY 99  1107 1107 GLY GLY A . n 
A 1 100 ARG 100 1108 1108 ARG ARG A . n 
A 1 101 THR 101 1109 1109 THR THR A . n 
A 1 102 GLY 102 1110 1110 GLY GLY A . n 
A 1 103 SER 103 1111 1111 SER SER A . n 
A 1 104 LEU 104 1112 1112 LEU LEU A . n 
A 1 105 CYS 105 1113 1113 CYS CYS A . n 
A 1 106 VAL 106 1114 1114 VAL VAL A . n 
A 1 107 ARG 107 1115 1115 ARG ARG A . n 
A 1 108 ARG 108 1116 1116 ARG ARG A . n 
A 1 109 ALA 109 1117 1117 ALA ALA A . n 
A 1 110 VAL 110 1118 1118 VAL VAL A . n 
A 1 111 TYR 111 1119 1119 TYR TYR A . n 
A 1 112 TYR 112 1120 1120 TYR TYR A . n 
A 1 113 ASP 113 1121 1121 ASP ASP A . n 
A 1 114 PRO 114 1122 1122 PRO PRO A . n 
A 1 115 GLU 115 1123 1123 GLU GLU A . n 
A 1 116 THR 116 1124 1124 THR THR A . n 
A 1 117 GLY 117 1125 1125 GLY GLY A . n 
A 1 118 LYS 118 1126 1126 LYS LYS A . n 
A 1 119 GLU 119 1127 1127 GLU GLU A . n 
A 1 120 ASP 120 1128 1128 ASP ASP A . n 
A 1 121 PRO 121 1129 1129 PRO PRO A . n 
A 1 122 SER 122 1130 1130 SER SER A . n 
A 1 123 LYS 123 1131 1131 LYS LYS A . n 
A 1 124 ASN 124 1132 1132 ASN ASN A . n 
A 1 125 GLY 125 1133 1133 GLY GLY A . n 
A 1 126 VAL 126 1134 1134 VAL VAL A . n 
A 1 127 CYS 127 1135 1135 CYS CYS A . n 
A 1 128 SER 128 1136 1136 SER SER A . n 
A 1 129 ASN 129 1137 1137 ASN ASN A . n 
A 1 130 PHE 130 1138 1138 PHE PHE A . n 
A 1 131 LEU 131 1139 1139 LEU LEU A . n 
A 1 132 CYS 132 1140 1140 CYS CYS A . n 
A 1 133 ASN 133 1141 1141 ASN ASN A . n 
A 1 134 SER 134 1142 1142 SER SER A . n 
A 1 135 LYS 135 1143 1143 LYS LYS A . n 
A 1 136 PRO 136 1144 1144 PRO PRO A . n 
A 1 137 GLY 137 1145 1145 GLY GLY A . n 
A 1 138 ASP 138 1146 1146 ASP ASP A . n 
A 1 139 LYS 139 1147 1147 LYS LYS A . n 
A 1 140 ILE 140 1148 1148 ILE ILE A . n 
A 1 141 GLN 141 1149 1149 GLN GLN A . n 
A 1 142 LEU 142 1150 1150 LEU LEU A . n 
A 1 143 THR 143 1151 1151 THR THR A . n 
A 1 144 GLY 144 1152 1152 GLY GLY A . n 
A 1 145 PRO 145 1153 1153 PRO PRO A . n 
A 1 146 SER 146 1154 1154 SER SER A . n 
A 1 147 GLY 147 1155 1155 GLY GLY A . n 
A 1 148 LYS 148 1156 1156 LYS LYS A . n 
A 1 149 ILE 149 1157 1157 ILE ILE A . n 
A 1 150 MET 150 1158 1158 MET MET A . n 
A 1 151 LEU 151 1159 1159 LEU LEU A . n 
A 1 152 LEU 152 1160 1160 LEU LEU A . n 
A 1 153 PRO 153 1161 1161 PRO PRO A . n 
A 1 154 GLU 154 1162 1162 GLU GLU A . n 
A 1 155 GLU 155 1163 1163 GLU GLU A . n 
A 1 156 ASP 156 1164 1164 ASP ASP A . n 
A 1 157 PRO 157 1165 1165 PRO PRO A . n 
A 1 158 ASN 158 1166 1166 ASN ASN A . n 
A 1 159 ALA 159 1167 1167 ALA ALA A . n 
A 1 160 THR 160 1168 1168 THR THR A . n 
A 1 161 HIS 161 1169 1169 HIS HIS A . n 
A 1 162 ILE 162 1170 1170 ILE ILE A . n 
A 1 163 MET 163 1171 1171 MET MET A . n 
A 1 164 ILE 164 1172 1172 ILE ILE A . n 
A 1 165 ALA 165 1173 1173 ALA ALA A . n 
A 1 166 THR 166 1174 1174 THR THR A . n 
A 1 167 GLY 167 1175 1175 GLY GLY A . n 
A 1 168 THR 168 1176 1176 THR THR A . n 
A 1 169 GLY 169 1177 1177 GLY GLY A . n 
A 1 170 VAL 170 1178 1178 VAL VAL A . n 
A 1 171 ALA 171 1179 1179 ALA ALA A . n 
A 1 172 PRO 172 1180 1180 PRO PRO A . n 
A 1 173 PHE 173 1181 1181 PHE PHE A . n 
A 1 174 ARG 174 1182 1182 ARG ARG A . n 
A 1 175 GLY 175 1183 1183 GLY GLY A . n 
A 1 176 TYR 176 1184 1184 TYR TYR A . n 
A 1 177 LEU 177 1185 1185 LEU LEU A . n 
A 1 178 ARG 178 1186 1186 ARG ARG A . n 
A 1 179 ARG 179 1187 1187 ARG ARG A . n 
A 1 180 MET 180 1188 1188 MET MET A . n 
A 1 181 PHE 181 1189 1189 PHE PHE A . n 
A 1 182 MET 182 1190 1190 MET MET A . n 
A 1 183 GLU 183 1191 1191 GLU GLU A . n 
A 1 184 ASP 184 1192 1192 ASP ASP A . n 
A 1 185 VAL 185 1193 1193 VAL VAL A . n 
A 1 186 PRO 186 1194 1194 PRO PRO A . n 
A 1 187 ASN 187 1195 1195 ASN ASN A . n 
A 1 188 TYR 188 1196 1196 TYR TYR A . n 
A 1 189 ARG 189 1197 1197 ARG ARG A . n 
A 1 190 PHE 190 1198 1198 PHE PHE A . n 
A 1 191 GLY 191 1199 1199 GLY GLY A . n 
A 1 192 GLY 192 1200 1200 GLY GLY A . n 
A 1 193 LEU 193 1201 1201 LEU LEU A . n 
A 1 194 ALA 194 1202 1202 ALA ALA A . n 
A 1 195 TRP 195 1203 1203 TRP TRP A . n 
A 1 196 LEU 196 1204 1204 LEU LEU A . n 
A 1 197 PHE 197 1205 1205 PHE PHE A . n 
A 1 198 LEU 198 1206 1206 LEU LEU A . n 
A 1 199 GLY 199 1207 1207 GLY GLY A . n 
A 1 200 VAL 200 1208 1208 VAL VAL A . n 
A 1 201 ALA 201 1209 1209 ALA ALA A . n 
A 1 202 ASN 202 1210 1210 ASN ASN A . n 
A 1 203 SER 203 1211 1211 SER SER A . n 
A 1 204 ASP 204 1212 1212 ASP ASP A . n 
A 1 205 SER 205 1213 1213 SER SER A . n 
A 1 206 LEU 206 1214 1214 LEU LEU A . n 
A 1 207 LEU 207 1215 1215 LEU LEU A . n 
A 1 208 TYR 208 1216 1216 TYR TYR A . n 
A 1 209 ASP 209 1217 1217 ASP ASP A . n 
A 1 210 GLU 210 1218 1218 GLU GLU A . n 
A 1 211 GLU 211 1219 1219 GLU GLU A . n 
A 1 212 PHE 212 1220 1220 PHE PHE A . n 
A 1 213 THR 213 1221 1221 THR THR A . n 
A 1 214 SER 214 1222 1222 SER SER A . n 
A 1 215 TYR 215 1223 1223 TYR TYR A . n 
A 1 216 LEU 216 1224 1224 LEU LEU A . n 
A 1 217 LYS 217 1225 1225 LYS LYS A . n 
A 1 218 GLN 218 1226 1226 GLN GLN A . n 
A 1 219 TYR 219 1227 1227 TYR TYR A . n 
A 1 220 PRO 220 1228 1228 PRO PRO A . n 
A 1 221 ASP 221 1229 1229 ASP ASP A . n 
A 1 222 ASN 222 1230 1230 ASN ASN A . n 
A 1 223 PHE 223 1231 1231 PHE PHE A . n 
A 1 224 ARG 224 1232 1232 ARG ARG A . n 
A 1 225 TYR 225 1233 1233 TYR TYR A . n 
A 1 226 ASP 226 1234 1234 ASP ASP A . n 
A 1 227 LYS 227 1235 1235 LYS LYS A . n 
A 1 228 ALA 228 1236 1236 ALA ALA A . n 
A 1 229 LEU 229 1237 1237 LEU LEU A . n 
A 1 230 SER 230 1238 1238 SER SER A . n 
A 1 231 ARG 231 1239 1239 ARG ARG A . n 
A 1 232 GLU 232 1240 1240 GLU GLU A . n 
A 1 233 GLN 233 1241 1241 GLN GLN A . n 
A 1 234 LYS 234 1242 1242 LYS LYS A . n 
A 1 235 ASN 235 1243 1243 ASN ASN A . n 
A 1 236 ARG 236 1244 1244 ARG ARG A . n 
A 1 237 SER 237 1245 1245 SER SER A . n 
A 1 238 GLY 238 1246 1246 GLY GLY A . n 
A 1 239 GLY 239 1247 1247 GLY GLY A . n 
A 1 240 LYS 240 1248 1248 LYS LYS A . n 
A 1 241 MET 241 1249 1249 MET MET A . n 
A 1 242 TYR 242 1250 1250 TYR TYR A . n 
A 1 243 VAL 243 1251 1251 VAL VAL A . n 
A 1 244 GLN 244 1252 1252 GLN GLN A . n 
A 1 245 ASP 245 1253 1253 ASP ASP A . n 
A 1 246 LYS 246 1254 1254 LYS LYS A . n 
A 1 247 ILE 247 1255 1255 ILE ILE A . n 
A 1 248 GLU 248 1256 1256 GLU GLU A . n 
A 1 249 GLU 249 1257 1257 GLU GLU A . n 
A 1 250 TYR 250 1258 1258 TYR TYR A . n 
A 1 251 SER 251 1259 1259 SER SER A . n 
A 1 252 ASP 252 1260 1260 ASP ASP A . n 
A 1 253 GLU 253 1261 1261 GLU GLU A . n 
A 1 254 ILE 254 1262 1262 ILE ILE A . n 
A 1 255 PHE 255 1263 1263 PHE PHE A . n 
A 1 256 LYS 256 1264 1264 LYS LYS A . n 
A 1 257 LEU 257 1265 1265 LEU LEU A . n 
A 1 258 LEU 258 1266 1266 LEU LEU A . n 
A 1 259 ASP 259 1267 1267 ASP ASP A . n 
A 1 260 GLY 260 1268 1268 GLY GLY A . n 
A 1 261 GLY 261 1269 1269 GLY GLY A . n 
A 1 262 ALA 262 1270 1270 ALA ALA A . n 
A 1 263 HIS 263 1271 1271 HIS HIS A . n 
A 1 264 ILE 264 1272 1272 ILE ILE A . n 
A 1 265 TYR 265 1273 1273 TYR TYR A . n 
A 1 266 PHE 266 1274 1274 PHE PHE A . n 
A 1 267 CYS 267 1275 1275 CYS CYS A . n 
A 1 268 GLY 268 1276 1276 GLY GLY A . n 
A 1 269 LEU 269 1277 1277 LEU LEU A . n 
A 1 270 LYS 270 1278 1278 LYS LYS A . n 
A 1 271 GLY 271 1279 1279 GLY GLY A . n 
A 1 272 MET 272 1280 1280 MET MET A . n 
A 1 273 MET 273 1281 1281 MET MET A . n 
A 1 274 PRO 274 1282 1282 PRO PRO A . n 
A 1 275 GLY 275 1283 1283 GLY GLY A . n 
A 1 276 ILE 276 1284 1284 ILE ILE A . n 
A 1 277 GLN 277 1285 1285 GLN GLN A . n 
A 1 278 ASP 278 1286 1286 ASP ASP A . n 
A 1 279 THR 279 1287 1287 THR THR A . n 
A 1 280 LEU 280 1288 1288 LEU LEU A . n 
A 1 281 LYS 281 1289 1289 LYS LYS A . n 
A 1 282 LYS 282 1290 1290 LYS LYS A . n 
A 1 283 VAL 283 1291 1291 VAL VAL A . n 
A 1 284 ALA 284 1292 1292 ALA ALA A . n 
A 1 285 GLU 285 1293 1293 GLU GLU A . n 
A 1 286 ARG 286 1294 1294 ARG ARG A . n 
A 1 287 ARG 287 1295 1295 ARG ARG A . n 
A 1 288 GLY 288 1296 1296 GLY GLY A . n 
A 1 289 GLU 289 1297 1297 GLU GLU A . n 
A 1 290 SER 290 1298 1298 SER SER A . n 
A 1 291 TRP 291 1299 1299 TRP TRP A . n 
A 1 292 ASP 292 1300 1300 ASP ASP A . n 
A 1 293 GLN 293 1301 1301 GLN GLN A . n 
A 1 294 LYS 294 1302 1302 LYS LYS A . n 
A 1 295 LEU 295 1303 1303 LEU LEU A . n 
A 1 296 ALA 296 1304 1304 ALA ALA A . n 
A 1 297 GLN 297 1305 1305 GLN GLN A . n 
A 1 298 LEU 298 1306 1306 LEU LEU A . n 
A 1 299 LYS 299 1307 1307 LYS LYS A . n 
A 1 300 LYS 300 1308 1308 LYS LYS A . n 
A 1 301 ASN 301 1309 1309 ASN ASN A . n 
A 1 302 LYS 302 1310 1310 LYS LYS A . n 
A 1 303 GLN 303 1311 1311 GLN GLN A . n 
A 1 304 TRP 304 1312 1312 TRP TRP A . n 
A 1 305 HIS 305 1313 1313 HIS HIS A . n 
A 1 306 VAL 306 1314 1314 VAL VAL A . n 
A 1 307 GLU 307 1315 1315 GLU GLU A . n 
A 1 308 VAL 308 1316 1316 VAL VAL A . n 
A 1 309 TYR 309 1317 1317 TYR TYR A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        FDA 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   FDA 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 MES 1   1401 1402 MES MES A . 
C 2 MES 1   1402 1501 MES MES A . 
D 3 FDA 1   1403 1502 FDA FDA A . 
E 4 HOH 1   1501 82   HOH HOH A . 
E 4 HOH 2   1502 283  HOH HOH A . 
E 4 HOH 3   1503 266  HOH HOH A . 
E 4 HOH 4   1504 116  HOH HOH A . 
E 4 HOH 5   1505 526  HOH HOH A . 
E 4 HOH 6   1506 47   HOH HOH A . 
E 4 HOH 7   1507 575  HOH HOH A . 
E 4 HOH 8   1508 223  HOH HOH A . 
E 4 HOH 9   1509 554  HOH HOH A . 
E 4 HOH 10  1510 587  HOH HOH A . 
E 4 HOH 11  1511 344  HOH HOH A . 
E 4 HOH 12  1512 119  HOH HOH A . 
E 4 HOH 13  1513 317  HOH HOH A . 
E 4 HOH 14  1514 31   HOH HOH A . 
E 4 HOH 15  1515 236  HOH HOH A . 
E 4 HOH 16  1516 351  HOH HOH A . 
E 4 HOH 17  1517 50   HOH HOH A . 
E 4 HOH 18  1518 412  HOH HOH A . 
E 4 HOH 19  1519 43   HOH HOH A . 
E 4 HOH 20  1520 32   HOH HOH A . 
E 4 HOH 21  1521 221  HOH HOH A . 
E 4 HOH 22  1522 13   HOH HOH A . 
E 4 HOH 23  1523 171  HOH HOH A . 
E 4 HOH 24  1524 42   HOH HOH A . 
E 4 HOH 25  1525 75   HOH HOH A . 
E 4 HOH 26  1526 439  HOH HOH A . 
E 4 HOH 27  1527 189  HOH HOH A . 
E 4 HOH 28  1528 256  HOH HOH A . 
E 4 HOH 29  1529 588  HOH HOH A . 
E 4 HOH 30  1530 135  HOH HOH A . 
E 4 HOH 31  1531 282  HOH HOH A . 
E 4 HOH 32  1532 633  HOH HOH A . 
E 4 HOH 33  1533 191  HOH HOH A . 
E 4 HOH 34  1534 148  HOH HOH A . 
E 4 HOH 35  1535 338  HOH HOH A . 
E 4 HOH 36  1536 384  HOH HOH A . 
E 4 HOH 37  1537 58   HOH HOH A . 
E 4 HOH 38  1538 570  HOH HOH A . 
E 4 HOH 39  1539 277  HOH HOH A . 
E 4 HOH 40  1540 330  HOH HOH A . 
E 4 HOH 41  1541 629  HOH HOH A . 
E 4 HOH 42  1542 2    HOH HOH A . 
E 4 HOH 43  1543 25   HOH HOH A . 
E 4 HOH 44  1544 61   HOH HOH A . 
E 4 HOH 45  1545 345  HOH HOH A . 
E 4 HOH 46  1546 142  HOH HOH A . 
E 4 HOH 47  1547 70   HOH HOH A . 
E 4 HOH 48  1548 89   HOH HOH A . 
E 4 HOH 49  1549 19   HOH HOH A . 
E 4 HOH 50  1550 624  HOH HOH A . 
E 4 HOH 51  1551 553  HOH HOH A . 
E 4 HOH 52  1552 21   HOH HOH A . 
E 4 HOH 53  1553 67   HOH HOH A . 
E 4 HOH 54  1554 88   HOH HOH A . 
E 4 HOH 55  1555 140  HOH HOH A . 
E 4 HOH 56  1556 139  HOH HOH A . 
E 4 HOH 57  1557 66   HOH HOH A . 
E 4 HOH 58  1558 297  HOH HOH A . 
E 4 HOH 59  1559 609  HOH HOH A . 
E 4 HOH 60  1560 326  HOH HOH A . 
E 4 HOH 61  1561 564  HOH HOH A . 
E 4 HOH 62  1562 595  HOH HOH A . 
E 4 HOH 63  1563 374  HOH HOH A . 
E 4 HOH 64  1564 418  HOH HOH A . 
E 4 HOH 65  1565 36   HOH HOH A . 
E 4 HOH 66  1566 27   HOH HOH A . 
E 4 HOH 67  1567 354  HOH HOH A . 
E 4 HOH 68  1568 181  HOH HOH A . 
E 4 HOH 69  1569 430  HOH HOH A . 
E 4 HOH 70  1570 261  HOH HOH A . 
E 4 HOH 71  1571 385  HOH HOH A . 
E 4 HOH 72  1572 423  HOH HOH A . 
E 4 HOH 73  1573 211  HOH HOH A . 
E 4 HOH 74  1574 287  HOH HOH A . 
E 4 HOH 75  1575 614  HOH HOH A . 
E 4 HOH 76  1576 76   HOH HOH A . 
E 4 HOH 77  1577 233  HOH HOH A . 
E 4 HOH 78  1578 104  HOH HOH A . 
E 4 HOH 79  1579 210  HOH HOH A . 
E 4 HOH 80  1580 225  HOH HOH A . 
E 4 HOH 81  1581 332  HOH HOH A . 
E 4 HOH 82  1582 176  HOH HOH A . 
E 4 HOH 83  1583 632  HOH HOH A . 
E 4 HOH 84  1584 3    HOH HOH A . 
E 4 HOH 85  1585 69   HOH HOH A . 
E 4 HOH 86  1586 90   HOH HOH A . 
E 4 HOH 87  1587 18   HOH HOH A . 
E 4 HOH 88  1588 226  HOH HOH A . 
E 4 HOH 89  1589 563  HOH HOH A . 
E 4 HOH 90  1590 187  HOH HOH A . 
E 4 HOH 91  1591 106  HOH HOH A . 
E 4 HOH 92  1592 72   HOH HOH A . 
E 4 HOH 93  1593 16   HOH HOH A . 
E 4 HOH 94  1594 38   HOH HOH A . 
E 4 HOH 95  1595 146  HOH HOH A . 
E 4 HOH 96  1596 81   HOH HOH A . 
E 4 HOH 97  1597 613  HOH HOH A . 
E 4 HOH 98  1598 214  HOH HOH A . 
E 4 HOH 99  1599 103  HOH HOH A . 
E 4 HOH 100 1600 252  HOH HOH A . 
E 4 HOH 101 1601 200  HOH HOH A . 
E 4 HOH 102 1602 130  HOH HOH A . 
E 4 HOH 103 1603 152  HOH HOH A . 
E 4 HOH 104 1604 68   HOH HOH A . 
E 4 HOH 105 1605 267  HOH HOH A . 
E 4 HOH 106 1606 65   HOH HOH A . 
E 4 HOH 107 1607 289  HOH HOH A . 
E 4 HOH 108 1608 452  HOH HOH A . 
E 4 HOH 109 1609 134  HOH HOH A . 
E 4 HOH 110 1610 87   HOH HOH A . 
E 4 HOH 111 1611 249  HOH HOH A . 
E 4 HOH 112 1612 45   HOH HOH A . 
E 4 HOH 113 1613 182  HOH HOH A . 
E 4 HOH 114 1614 251  HOH HOH A . 
E 4 HOH 115 1615 48   HOH HOH A . 
E 4 HOH 116 1616 615  HOH HOH A . 
E 4 HOH 117 1617 520  HOH HOH A . 
E 4 HOH 118 1618 352  HOH HOH A . 
E 4 HOH 119 1619 100  HOH HOH A . 
E 4 HOH 120 1620 12   HOH HOH A . 
E 4 HOH 121 1621 404  HOH HOH A . 
E 4 HOH 122 1622 230  HOH HOH A . 
E 4 HOH 123 1623 403  HOH HOH A . 
E 4 HOH 124 1624 442  HOH HOH A . 
E 4 HOH 125 1625 387  HOH HOH A . 
E 4 HOH 126 1626 183  HOH HOH A . 
E 4 HOH 127 1627 231  HOH HOH A . 
E 4 HOH 128 1628 203  HOH HOH A . 
E 4 HOH 129 1629 30   HOH HOH A . 
E 4 HOH 130 1630 578  HOH HOH A . 
E 4 HOH 131 1631 539  HOH HOH A . 
E 4 HOH 132 1632 497  HOH HOH A . 
E 4 HOH 133 1633 145  HOH HOH A . 
E 4 HOH 134 1634 115  HOH HOH A . 
E 4 HOH 135 1635 243  HOH HOH A . 
E 4 HOH 136 1636 568  HOH HOH A . 
E 4 HOH 137 1637 190  HOH HOH A . 
E 4 HOH 138 1638 197  HOH HOH A . 
E 4 HOH 139 1639 481  HOH HOH A . 
E 4 HOH 140 1640 174  HOH HOH A . 
E 4 HOH 141 1641 35   HOH HOH A . 
E 4 HOH 142 1642 7    HOH HOH A . 
E 4 HOH 143 1643 49   HOH HOH A . 
E 4 HOH 144 1644 17   HOH HOH A . 
E 4 HOH 145 1645 44   HOH HOH A . 
E 4 HOH 146 1646 4    HOH HOH A . 
E 4 HOH 147 1647 15   HOH HOH A . 
E 4 HOH 148 1648 371  HOH HOH A . 
E 4 HOH 149 1649 567  HOH HOH A . 
E 4 HOH 150 1650 1    HOH HOH A . 
E 4 HOH 151 1651 22   HOH HOH A . 
E 4 HOH 152 1652 175  HOH HOH A . 
E 4 HOH 153 1653 143  HOH HOH A . 
E 4 HOH 154 1654 23   HOH HOH A . 
E 4 HOH 155 1655 107  HOH HOH A . 
E 4 HOH 156 1656 11   HOH HOH A . 
E 4 HOH 157 1657 55   HOH HOH A . 
E 4 HOH 158 1658 193  HOH HOH A . 
E 4 HOH 159 1659 179  HOH HOH A . 
E 4 HOH 160 1660 507  HOH HOH A . 
E 4 HOH 161 1661 6    HOH HOH A . 
E 4 HOH 162 1662 5    HOH HOH A . 
E 4 HOH 163 1663 556  HOH HOH A . 
E 4 HOH 164 1664 33   HOH HOH A . 
E 4 HOH 165 1665 555  HOH HOH A . 
E 4 HOH 166 1666 393  HOH HOH A . 
E 4 HOH 167 1667 101  HOH HOH A . 
E 4 HOH 168 1668 620  HOH HOH A . 
E 4 HOH 169 1669 138  HOH HOH A . 
E 4 HOH 170 1670 158  HOH HOH A . 
E 4 HOH 171 1671 314  HOH HOH A . 
E 4 HOH 172 1672 204  HOH HOH A . 
E 4 HOH 173 1673 60   HOH HOH A . 
E 4 HOH 174 1674 631  HOH HOH A . 
E 4 HOH 175 1675 24   HOH HOH A . 
E 4 HOH 176 1676 112  HOH HOH A . 
E 4 HOH 177 1677 99   HOH HOH A . 
E 4 HOH 178 1678 39   HOH HOH A . 
E 4 HOH 179 1679 167  HOH HOH A . 
E 4 HOH 180 1680 14   HOH HOH A . 
E 4 HOH 181 1681 26   HOH HOH A . 
E 4 HOH 182 1682 168  HOH HOH A . 
E 4 HOH 183 1683 34   HOH HOH A . 
E 4 HOH 184 1684 71   HOH HOH A . 
E 4 HOH 185 1685 559  HOH HOH A . 
E 4 HOH 186 1686 51   HOH HOH A . 
E 4 HOH 187 1687 363  HOH HOH A . 
E 4 HOH 188 1688 28   HOH HOH A . 
E 4 HOH 189 1689 113  HOH HOH A . 
E 4 HOH 190 1690 85   HOH HOH A . 
E 4 HOH 191 1691 84   HOH HOH A . 
E 4 HOH 192 1692 122  HOH HOH A . 
E 4 HOH 193 1693 618  HOH HOH A . 
E 4 HOH 194 1694 320  HOH HOH A . 
E 4 HOH 195 1695 29   HOH HOH A . 
E 4 HOH 196 1696 86   HOH HOH A . 
E 4 HOH 197 1697 124  HOH HOH A . 
E 4 HOH 198 1698 108  HOH HOH A . 
E 4 HOH 199 1699 218  HOH HOH A . 
E 4 HOH 200 1700 54   HOH HOH A . 
E 4 HOH 201 1701 41   HOH HOH A . 
E 4 HOH 202 1702 365  HOH HOH A . 
E 4 HOH 203 1703 474  HOH HOH A . 
E 4 HOH 204 1704 46   HOH HOH A . 
E 4 HOH 205 1705 173  HOH HOH A . 
E 4 HOH 206 1706 265  HOH HOH A . 
E 4 HOH 207 1707 10   HOH HOH A . 
E 4 HOH 208 1708 576  HOH HOH A . 
E 4 HOH 209 1709 164  HOH HOH A . 
E 4 HOH 210 1710 471  HOH HOH A . 
E 4 HOH 211 1711 394  HOH HOH A . 
E 4 HOH 212 1712 599  HOH HOH A . 
E 4 HOH 213 1713 73   HOH HOH A . 
E 4 HOH 214 1714 8    HOH HOH A . 
E 4 HOH 215 1715 161  HOH HOH A . 
E 4 HOH 216 1716 205  HOH HOH A . 
E 4 HOH 217 1717 97   HOH HOH A . 
E 4 HOH 218 1718 565  HOH HOH A . 
E 4 HOH 219 1719 52   HOH HOH A . 
E 4 HOH 220 1720 137  HOH HOH A . 
E 4 HOH 221 1721 156  HOH HOH A . 
E 4 HOH 222 1722 269  HOH HOH A . 
E 4 HOH 223 1723 235  HOH HOH A . 
E 4 HOH 224 1724 64   HOH HOH A . 
E 4 HOH 225 1725 593  HOH HOH A . 
E 4 HOH 226 1726 309  HOH HOH A . 
E 4 HOH 227 1727 196  HOH HOH A . 
E 4 HOH 228 1728 294  HOH HOH A . 
E 4 HOH 229 1729 186  HOH HOH A . 
E 4 HOH 230 1730 617  HOH HOH A . 
E 4 HOH 231 1731 532  HOH HOH A . 
E 4 HOH 232 1732 172  HOH HOH A . 
E 4 HOH 233 1733 446  HOH HOH A . 
E 4 HOH 234 1734 154  HOH HOH A . 
E 4 HOH 235 1735 558  HOH HOH A . 
E 4 HOH 236 1736 62   HOH HOH A . 
E 4 HOH 237 1737 227  HOH HOH A . 
E 4 HOH 238 1738 131  HOH HOH A . 
E 4 HOH 239 1739 417  HOH HOH A . 
E 4 HOH 240 1740 589  HOH HOH A . 
E 4 HOH 241 1741 40   HOH HOH A . 
E 4 HOH 242 1742 626  HOH HOH A . 
E 4 HOH 243 1743 120  HOH HOH A . 
E 4 HOH 244 1744 279  HOH HOH A . 
E 4 HOH 245 1745 92   HOH HOH A . 
E 4 HOH 246 1746 133  HOH HOH A . 
E 4 HOH 247 1747 195  HOH HOH A . 
E 4 HOH 248 1748 583  HOH HOH A . 
E 4 HOH 249 1749 162  HOH HOH A . 
E 4 HOH 250 1750 580  HOH HOH A . 
E 4 HOH 251 1751 80   HOH HOH A . 
E 4 HOH 252 1752 123  HOH HOH A . 
E 4 HOH 253 1753 56   HOH HOH A . 
E 4 HOH 254 1754 59   HOH HOH A . 
E 4 HOH 255 1755 91   HOH HOH A . 
E 4 HOH 256 1756 548  HOH HOH A . 
E 4 HOH 257 1757 53   HOH HOH A . 
E 4 HOH 258 1758 272  HOH HOH A . 
E 4 HOH 259 1759 377  HOH HOH A . 
E 4 HOH 260 1760 353  HOH HOH A . 
E 4 HOH 261 1761 9    HOH HOH A . 
E 4 HOH 262 1762 177  HOH HOH A . 
E 4 HOH 263 1763 383  HOH HOH A . 
E 4 HOH 264 1764 634  HOH HOH A . 
E 4 HOH 265 1765 157  HOH HOH A . 
E 4 HOH 266 1766 268  HOH HOH A . 
E 4 HOH 267 1767 562  HOH HOH A . 
E 4 HOH 268 1768 222  HOH HOH A . 
E 4 HOH 269 1769 125  HOH HOH A . 
E 4 HOH 270 1770 421  HOH HOH A . 
E 4 HOH 271 1771 592  HOH HOH A . 
E 4 HOH 272 1772 188  HOH HOH A . 
E 4 HOH 273 1773 132  HOH HOH A . 
E 4 HOH 274 1774 207  HOH HOH A . 
E 4 HOH 275 1775 57   HOH HOH A . 
E 4 HOH 276 1776 319  HOH HOH A . 
E 4 HOH 277 1777 98   HOH HOH A . 
E 4 HOH 278 1778 313  HOH HOH A . 
E 4 HOH 279 1779 83   HOH HOH A . 
E 4 HOH 280 1780 318  HOH HOH A . 
E 4 HOH 281 1781 290  HOH HOH A . 
E 4 HOH 282 1782 490  HOH HOH A . 
E 4 HOH 283 1783 327  HOH HOH A . 
E 4 HOH 284 1784 603  HOH HOH A . 
E 4 HOH 285 1785 577  HOH HOH A . 
E 4 HOH 286 1786 331  HOH HOH A . 
E 4 HOH 287 1787 202  HOH HOH A . 
E 4 HOH 288 1788 388  HOH HOH A . 
E 4 HOH 289 1789 77   HOH HOH A . 
E 4 HOH 290 1790 296  HOH HOH A . 
E 4 HOH 291 1791 429  HOH HOH A . 
E 4 HOH 292 1792 346  HOH HOH A . 
E 4 HOH 293 1793 153  HOH HOH A . 
E 4 HOH 294 1794 437  HOH HOH A . 
E 4 HOH 295 1795 312  HOH HOH A . 
E 4 HOH 296 1796 311  HOH HOH A . 
E 4 HOH 297 1797 95   HOH HOH A . 
E 4 HOH 298 1798 149  HOH HOH A . 
E 4 HOH 299 1799 389  HOH HOH A . 
E 4 HOH 300 1800 333  HOH HOH A . 
E 4 HOH 301 1801 608  HOH HOH A . 
E 4 HOH 302 1802 551  HOH HOH A . 
E 4 HOH 303 1803 305  HOH HOH A . 
E 4 HOH 304 1804 308  HOH HOH A . 
E 4 HOH 305 1805 185  HOH HOH A . 
E 4 HOH 306 1806 291  HOH HOH A . 
E 4 HOH 307 1807 155  HOH HOH A . 
E 4 HOH 308 1808 602  HOH HOH A . 
E 4 HOH 309 1809 360  HOH HOH A . 
E 4 HOH 310 1810 379  HOH HOH A . 
E 4 HOH 311 1811 409  HOH HOH A . 
E 4 HOH 312 1812 264  HOH HOH A . 
E 4 HOH 313 1813 244  HOH HOH A . 
E 4 HOH 314 1814 128  HOH HOH A . 
E 4 HOH 315 1815 136  HOH HOH A . 
E 4 HOH 316 1816 329  HOH HOH A . 
E 4 HOH 317 1817 79   HOH HOH A . 
E 4 HOH 318 1818 105  HOH HOH A . 
E 4 HOH 319 1819 219  HOH HOH A . 
E 4 HOH 320 1820 376  HOH HOH A . 
E 4 HOH 321 1821 323  HOH HOH A . 
E 4 HOH 322 1822 480  HOH HOH A . 
E 4 HOH 323 1823 118  HOH HOH A . 
E 4 HOH 324 1824 560  HOH HOH A . 
E 4 HOH 325 1825 466  HOH HOH A . 
E 4 HOH 326 1826 361  HOH HOH A . 
E 4 HOH 327 1827 114  HOH HOH A . 
E 4 HOH 328 1828 512  HOH HOH A . 
E 4 HOH 329 1829 126  HOH HOH A . 
E 4 HOH 330 1830 438  HOH HOH A . 
E 4 HOH 331 1831 121  HOH HOH A . 
E 4 HOH 332 1832 598  HOH HOH A . 
E 4 HOH 333 1833 357  HOH HOH A . 
E 4 HOH 334 1834 129  HOH HOH A . 
E 4 HOH 335 1835 102  HOH HOH A . 
E 4 HOH 336 1836 228  HOH HOH A . 
E 4 HOH 337 1837 444  HOH HOH A . 
E 4 HOH 338 1838 586  HOH HOH A . 
E 4 HOH 339 1839 109  HOH HOH A . 
E 4 HOH 340 1840 584  HOH HOH A . 
E 4 HOH 341 1841 492  HOH HOH A . 
E 4 HOH 342 1842 594  HOH HOH A . 
E 4 HOH 343 1843 301  HOH HOH A . 
E 4 HOH 344 1844 307  HOH HOH A . 
E 4 HOH 345 1845 273  HOH HOH A . 
E 4 HOH 346 1846 178  HOH HOH A . 
E 4 HOH 347 1847 199  HOH HOH A . 
E 4 HOH 348 1848 573  HOH HOH A . 
E 4 HOH 349 1849 240  HOH HOH A . 
E 4 HOH 350 1850 627  HOH HOH A . 
E 4 HOH 351 1851 484  HOH HOH A . 
E 4 HOH 352 1852 299  HOH HOH A . 
E 4 HOH 353 1853 213  HOH HOH A . 
E 4 HOH 354 1854 457  HOH HOH A . 
E 4 HOH 355 1855 274  HOH HOH A . 
E 4 HOH 356 1856 600  HOH HOH A . 
E 4 HOH 357 1857 117  HOH HOH A . 
E 4 HOH 358 1858 621  HOH HOH A . 
E 4 HOH 359 1859 486  HOH HOH A . 
E 4 HOH 360 1860 216  HOH HOH A . 
E 4 HOH 361 1861 229  HOH HOH A . 
E 4 HOH 362 1862 151  HOH HOH A . 
E 4 HOH 363 1863 260  HOH HOH A . 
E 4 HOH 364 1864 93   HOH HOH A . 
E 4 HOH 365 1865 304  HOH HOH A . 
E 4 HOH 366 1866 515  HOH HOH A . 
E 4 HOH 367 1867 241  HOH HOH A . 
E 4 HOH 368 1868 367  HOH HOH A . 
E 4 HOH 369 1869 401  HOH HOH A . 
E 4 HOH 370 1870 159  HOH HOH A . 
E 4 HOH 371 1871 386  HOH HOH A . 
E 4 HOH 372 1872 426  HOH HOH A . 
E 4 HOH 373 1873 194  HOH HOH A . 
E 4 HOH 374 1874 625  HOH HOH A . 
E 4 HOH 375 1875 369  HOH HOH A . 
E 4 HOH 376 1876 391  HOH HOH A . 
E 4 HOH 377 1877 616  HOH HOH A . 
E 4 HOH 378 1878 300  HOH HOH A . 
E 4 HOH 379 1879 184  HOH HOH A . 
E 4 HOH 380 1880 479  HOH HOH A . 
E 4 HOH 381 1881 362  HOH HOH A . 
E 4 HOH 382 1882 278  HOH HOH A . 
E 4 HOH 383 1883 623  HOH HOH A . 
E 4 HOH 384 1884 434  HOH HOH A . 
E 4 HOH 385 1885 37   HOH HOH A . 
E 4 HOH 386 1886 349  HOH HOH A . 
E 4 HOH 387 1887 372  HOH HOH A . 
E 4 HOH 388 1888 460  HOH HOH A . 
E 4 HOH 389 1889 585  HOH HOH A . 
E 4 HOH 390 1890 321  HOH HOH A . 
E 4 HOH 391 1891 596  HOH HOH A . 
E 4 HOH 392 1892 258  HOH HOH A . 
E 4 HOH 393 1893 238  HOH HOH A . 
E 4 HOH 394 1894 217  HOH HOH A . 
E 4 HOH 395 1895 259  HOH HOH A . 
E 4 HOH 396 1896 74   HOH HOH A . 
E 4 HOH 397 1897 245  HOH HOH A . 
E 4 HOH 398 1898 170  HOH HOH A . 
E 4 HOH 399 1899 180  HOH HOH A . 
E 4 HOH 400 1900 212  HOH HOH A . 
E 4 HOH 401 1901 476  HOH HOH A . 
E 4 HOH 402 1902 306  HOH HOH A . 
E 4 HOH 403 1903 302  HOH HOH A . 
E 4 HOH 404 1904 541  HOH HOH A . 
E 4 HOH 405 1905 288  HOH HOH A . 
E 4 HOH 406 1906 208  HOH HOH A . 
E 4 HOH 407 1907 163  HOH HOH A . 
E 4 HOH 408 1908 342  HOH HOH A . 
E 4 HOH 409 1909 579  HOH HOH A . 
E 4 HOH 410 1910 571  HOH HOH A . 
E 4 HOH 411 1911 402  HOH HOH A . 
E 4 HOH 412 1912 127  HOH HOH A . 
E 4 HOH 413 1913 356  HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A GLU 1043 ? CG  ? A GLU 35  CG  
2  1 Y 1 A GLU 1043 ? CD  ? A GLU 35  CD  
3  1 Y 1 A GLU 1043 ? OE1 ? A GLU 35  OE1 
4  1 Y 1 A GLU 1043 ? OE2 ? A GLU 35  OE2 
5  1 Y 1 A GLN 1226 ? CG  ? A GLN 218 CG  
6  1 Y 1 A GLN 1226 ? CD  ? A GLN 218 CD  
7  1 Y 1 A GLN 1226 ? OE1 ? A GLN 218 OE1 
8  1 Y 1 A GLN 1226 ? NE2 ? A GLN 218 NE2 
9  1 Y 1 A GLU 1293 ? CG  ? A GLU 285 CG  
10 1 Y 1 A GLU 1293 ? CD  ? A GLU 285 CD  
11 1 Y 1 A GLU 1293 ? OE1 ? A GLU 285 OE1 
12 1 Y 1 A GLU 1293 ? OE2 ? A GLU 285 OE2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.dependencies 
_software.description 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.pdbx_ordinal 
_software.type 
_software.version 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? STARGazer ? ? 1 ? .        
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? STARGazer ? ? 2 ? .        
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER    ? ? 3 ? .        
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC    ? ? 4 ? 5.8.0425 
# 
_cell.angle_alpha                  90 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9KK7 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     59.32 
_cell.length_a_esd                 ? 
_cell.length_b                     59.32 
_cell.length_b_esd                 ? 
_cell.length_c                     187.69 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9KK7 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                154 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 32 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9KK7 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'NEUTRON DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             ? 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          ? 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'BATCH MODE' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    PEG2000 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     DIFFRACTOMETER 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         iBIX 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-12-10 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   L 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             LAUE 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             neutron 
# 
loop_
_diffrn_radiation_wavelength.id 
_diffrn_radiation_wavelength.wavelength 
_diffrn_radiation_wavelength.wt 
1 2.05 1.0 
2 5.38 1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'SPALLATION SOURCE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        'J-PARC MLF BEAMLINE BL-03' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        2.05-5.38 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL-03 
_diffrn_source.pdbx_synchrotron_site       'JPARC MLF' 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9KK7 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.80 
_reflns.d_resolution_low                               19.425 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     36398 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                9.5293 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          5.41 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                0.1669 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.9613 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.80 
_reflns_shell.d_res_low                                     1.86 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3565 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               0.7279 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.3668 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            -0.027 
_refine.aniso_B[1][2]                            -0.014 
_refine.aniso_B[1][3]                            -0.000 
_refine.aniso_B[2][2]                            -0.027 
_refine.aniso_B[2][3]                            -0.000 
_refine.aniso_B[3][3]                            0.089 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               22.416 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.942 
_refine.correlation_coeff_Fo_to_Fc_free          0.894 
_refine.details                                  'Hydrogens have been used if present in the input file' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9KK7 
_refine.pdbx_refine_id                           'NEUTRON DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.800 
_refine.ls_d_res_low                             19.425 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     36397 
_refine.ls_number_reflns_R_free                  1771 
_refine.ls_number_reflns_R_work                  34626 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.660 
_refine.ls_percent_reflns_R_free                 4.866 
_refine.ls_R_factor_all                          0.199 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.2462 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1971 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      5H59 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.185 
_refine.pdbx_overall_ESU_R_Free                  0.161 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             5.208 
_refine.overall_SU_ML                            0.152 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'NEUTRON DIFFRACTION' ? 0.009  0.014     4090  ? r_bond_refined_d               ? ? 
'NEUTRON DIFFRACTION' ? 0.001  0.017     1935  ? r_bond_other_d                 ? ? 
'NEUTRON DIFFRACTION' ? 0.000  0.007     7866  ? r_ext_dist_refined_b           ? ? 
'NEUTRON DIFFRACTION' ? 1.783  2.008     5103  ? r_angle_refined_deg            ? ? 
'NEUTRON DIFFRACTION' ? 0.603  1.707     4712  ? r_angle_other_deg              ? ? 
'NEUTRON DIFFRACTION' ? 6.344  5.000     324   ? r_dihedral_angle_1_deg         ? ? 
'NEUTRON DIFFRACTION' ? 7.013  10993.956 91    ? r_dihedral_angle_2_deg         ? ? 
'NEUTRON DIFFRACTION' ? 15.500 10.000    510   ? r_dihedral_angle_3_deg         ? ? 
'NEUTRON DIFFRACTION' ? 3.796  10.000    149   ? r_dihedral_angle_other_3_deg   ? ? 
'NEUTRON DIFFRACTION' ? 16.538 10.000    117   ? r_dihedral_angle_6_deg         ? ? 
'NEUTRON DIFFRACTION' ? 13.899 10.000    32    ? r_dihedral_angle_other_6_deg   ? ? 
'NEUTRON DIFFRACTION' ? 0.098  0.200     371   ? r_chiral_restr                 ? ? 
'NEUTRON DIFFRACTION' ? 0.011  0.020     3634  ? r_gen_planes_refined           ? ? 
'NEUTRON DIFFRACTION' ? 0.000  0.020     163   ? r_gen_planes_other             ? ? 
'NEUTRON DIFFRACTION' ? 0.237  0.200     1283  ? r_nbd_refined                  ? ? 
'NEUTRON DIFFRACTION' ? 0.172  0.200     1259  ? r_symmetry_nbd_other           ? ? 
'NEUTRON DIFFRACTION' ? 0.188  0.200     1288  ? r_nbtor_refined                ? ? 
'NEUTRON DIFFRACTION' ? 0.042  0.200     109   ? r_symmetry_nbtor_other         ? ? 
'NEUTRON DIFFRACTION' ? 0.191  0.200     355   ? r_xyhbond_nbd_refined          ? ? 
'NEUTRON DIFFRACTION' ? 0.311  0.200     72    ? r_symmetry_nbd_refined         ? ? 
'NEUTRON DIFFRACTION' ? 0.192  0.200     68    ? r_nbd_other                    ? ? 
'NEUTRON DIFFRACTION' ? 0.184  0.200     36    ? r_symmetry_xyhbond_nbd_refined ? ? 
'NEUTRON DIFFRACTION' ? 1.566  1.804     1588  ? r_mcbond_it                    ? ? 
'NEUTRON DIFFRACTION' ? 1.565  1.804     1588  ? r_mcbond_other                 ? ? 
'NEUTRON DIFFRACTION' ? 2.224  3.136     2211  ? r_mcangle_it                   ? ? 
'NEUTRON DIFFRACTION' ? 2.223  3.136     2212  ? r_mcangle_other                ? ? 
'NEUTRON DIFFRACTION' ? 2.285  2.523     2502  ? r_scbond_it                    ? ? 
'NEUTRON DIFFRACTION' ? 2.363  2.195     1676  ? r_scbond_other                 ? ? 
'NEUTRON DIFFRACTION' ? 3.414  3.930     2891  ? r_scangle_it                   ? ? 
'NEUTRON DIFFRACTION' ? 3.575  3.797     2482  ? r_scangle_other                ? ? 
'NEUTRON DIFFRACTION' ? 5.090  27.871    10163 ? r_lrange_it                    ? ? 
'NEUTRON DIFFRACTION' ? 4.794  26.360    9833  ? r_lrange_other                 ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'NEUTRON DIFFRACTION' 1.800 1.846  2631 . 118 2513 100.0000 . 0.303 . . 0.302 . . . . . 0.297 . 20 . 0.927 0.923 0.329 
'NEUTRON DIFFRACTION' 1.846 1.896  2535 . 144 2391 100.0000 . 0.294 . . 0.293 . . . . . 0.285 . 20 . 0.933 0.926 0.304 
'NEUTRON DIFFRACTION' 1.896 1.951  2477 . 121 2356 100.0000 . 0.279 . . 0.278 . . . . . 0.268 . 20 . 0.940 0.923 0.301 
'NEUTRON DIFFRACTION' 1.951 2.010  2436 . 135 2301 100.0000 . 0.267 . . 0.265 . . . . . 0.254 . 20 . 0.946 0.937 0.285 
'NEUTRON DIFFRACTION' 2.010 2.076  2394 . 128 2266 100.0000 . 0.249 . . 0.247 . . . . . 0.228 . 20 . 0.955 0.938 0.294 
'NEUTRON DIFFRACTION' 2.076 2.148  2256 . 134 2122 100.0000 . 0.224 . . 0.222 . . . . . 0.201 . 20 . 0.963 0.962 0.245 
'NEUTRON DIFFRACTION' 2.148 2.228  2224 . 92  2132 100.0000 . 0.207 . . 0.207 . . . . . 0.181 . 20 . 0.970 0.966 0.211 
'NEUTRON DIFFRACTION' 2.228 2.317  2119 . 119 2000 100.0000 . 0.205 . . 0.201 . . . . . 0.173 . 20 . 0.972 0.953 0.269 
'NEUTRON DIFFRACTION' 2.317 2.419  2049 . 108 1941 100.0000 . 0.190 . . 0.188 . . . . . 0.157 . 20 . 0.976 0.962 0.233 
'NEUTRON DIFFRACTION' 2.419 2.535  1967 . 96  1871 100.0000 . 0.175 . . 0.172 . . . . . 0.143 . 20 . 0.980 0.958 0.241 
'NEUTRON DIFFRACTION' 2.535 2.669  1879 . 90  1789 100.0000 . 0.178 . . 0.175 . . . . . 0.142 . 20 . 0.980 0.967 0.233 
'NEUTRON DIFFRACTION' 2.669 2.828  1801 . 76  1725 100.0000 . 0.161 . . 0.159 . . . . . 0.130 . 20 . 0.983 0.964 0.215 
'NEUTRON DIFFRACTION' 2.828 3.019  1680 . 70  1610 100.0000 . 0.166 . . 0.165 . . . . . 0.131 . 20 . 0.982 0.977 0.196 
'NEUTRON DIFFRACTION' 3.019 3.254  1579 . 85  1493 99.9367  . 0.173 . . 0.169 . . . . . 0.140 . 20 . 0.981 0.966 0.242 
'NEUTRON DIFFRACTION' 3.254 3.555  1452 . 57  1395 100.0000 . 0.183 . . 0.181 . . . . . 0.156 . 20 . 0.981 0.979 0.212 
'NEUTRON DIFFRACTION' 3.555 3.958  1370 . 57  1312 99.9270  . 0.172 . . 0.171 . . . . . 0.153 . 20 . 0.986 0.976 0.215 
'NEUTRON DIFFRACTION' 3.958 4.539  1181 . 51  1126 99.6613  . 0.145 . . 0.143 . . . . . 0.122 . 20 . 0.989 0.974 0.203 
'NEUTRON DIFFRACTION' 4.539 5.484  1037 . 41  995  99.9036  . 0.134 . . 0.133 . . . . . 0.111 . 20 . 0.990 0.983 0.190 
'NEUTRON DIFFRACTION' 5.484 7.464  851  . 35  814  99.7650  . 0.163 . . 0.160 . . . . . 0.136 . 20 . 0.985 0.968 0.246 
'NEUTRON DIFFRACTION' 7.464 19.425 562  . 14  474  86.8327  . 0.199 . . 0.195 . . . . . 0.170 . 20 . 0.978 0.945 0.332 
# 
_struct.entry_id                     9KK7 
_struct.title                        'Neutron structure of Ferredoxin-NADP+ reductase from maize root -Reduced form' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9KK7 
_struct_keywords.text            'electron transfer, Flavoprotein, OXIDOREDUCTASE' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    B4G043_MAIZE 
_struct_ref.pdbx_db_accession          B4G043 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SKVSVAPLHLESAKEPPLNTYKPKEPFTATIVSVESLVGPKAPGETCHIVIDHGGNVPYWEGQSYGVIPPGENPKKPGAP
QNVRLYSIASTRYGDNFDGRTGSLCVRRAVYYDPETGKEDPSKNGVCSNFLCNSKPGDKIQLTGPSGKIMLLPEEDPNAT
HIMIATGTGVAPFRGYLRRMFMEDVPNYRFGGLAWLFLGVANSDSLLYDEEFTSYLKQYPDNFRYDKALSREQKNRSGGK
MYVQDKIEEYSDEIFKLLDGGAHIYFCGLKGMMPGIQDTLKKVAERRGESWDQKLAQLKKNKQWHVEVY
;
_struct_ref.pdbx_align_begin           73 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9KK7 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 309 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             B4G043 
_struct_ref_seq.db_align_beg                  73 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  381 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1009 
_struct_ref_seq.pdbx_auth_seq_align_end       1317 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1610  ? 
1 MORE         -4    ? 
1 'SSA (A^2)'  14750 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PRO A 7   ? SER A 12  ? PRO A 1015 SER A 1020 5 ? 6  
HELX_P HELX_P2  AA2 ASP A 120 ? ASN A 124 ? ASP A 1128 ASN A 1132 5 ? 5  
HELX_P HELX_P3  AA3 GLY A 125 ? ASN A 133 ? GLY A 1133 ASN A 1141 1 ? 9  
HELX_P HELX_P4  AA4 VAL A 170 ? MET A 182 ? VAL A 1178 MET A 1190 1 ? 13 
HELX_P HELX_P5  AA5 ASN A 202 ? LEU A 206 ? ASN A 1210 LEU A 1214 5 ? 5  
HELX_P HELX_P6  AA6 TYR A 208 ? TYR A 219 ? TYR A 1216 TYR A 1227 1 ? 12 
HELX_P HELX_P7  AA7 TYR A 242 ? TYR A 250 ? TYR A 1250 TYR A 1258 1 ? 9  
HELX_P HELX_P8  AA8 TYR A 250 ? GLY A 260 ? TYR A 1258 GLY A 1268 1 ? 11 
HELX_P HELX_P9  AA9 MET A 272 ? GLY A 288 ? MET A 1280 GLY A 1296 1 ? 17 
HELX_P HELX_P10 AB1 SER A 290 ? ASN A 301 ? SER A 1298 ASN A 1309 1 ? 12 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            disulf1 
_struct_conn.conn_type_id                  disulf 
_struct_conn.pdbx_leaving_atom_flag        ? 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            47 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           A 
_struct_conn.ptnr2_label_comp_id           CYS 
_struct_conn.ptnr2_label_seq_id            132 
_struct_conn.ptnr2_label_atom_id           SG 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             1055 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            CYS 
_struct_conn.ptnr2_auth_seq_id             1140 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               2.038 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      CYS 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       47 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      132 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       CYS 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        1055 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       1140 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               SG 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                . 
_pdbx_modification_feature.ref_pcm_id                         . 
_pdbx_modification_feature.ref_comp_id                        . 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 ALA 6   A . ? ALA 1014 A PRO 7   A ? PRO 1015 A 1 -4.38 
2 GLY 144 A . ? GLY 1152 A PRO 145 A ? PRO 1153 A 1 -1.04 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 6 ? 
AA2 ? 2 ? 
AA3 ? 5 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? parallel      
AA3 3 4 ? parallel      
AA3 4 5 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ARG A 84  ? SER A 87  ? ARG A 1092 SER A 1095 
AA1 2 SER A 64  ? ILE A 68  ? SER A 1072 ILE A 1076 
AA1 3 LYS A 139 ? SER A 146 ? LYS A 1147 SER A 1154 
AA1 4 PHE A 27  ? SER A 36  ? PHE A 1035 SER A 1044 
AA1 5 THR A 46  ? ASP A 52  ? THR A 1054 ASP A 1060 
AA1 6 THR A 101 ? ARG A 107 ? THR A 1109 ARG A 1115 
AA2 1 GLU A 72  ? ASN A 73  ? GLU A 1080 ASN A 1081 
AA2 2 LYS A 76  ? PRO A 80  ? LYS A 1084 PRO A 1088 
AA3 1 PHE A 223 ? LEU A 229 ? PHE A 1231 LEU A 1237 
AA3 2 LEU A 193 ? VAL A 200 ? LEU A 1201 VAL A 1208 
AA3 3 THR A 160 ? THR A 166 ? THR A 1168 THR A 1174 
AA3 4 HIS A 263 ? LEU A 269 ? HIS A 1271 LEU A 1277 
AA3 5 TRP A 304 ? TYR A 309 ? TRP A 1312 TYR A 1317 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O TYR A 86  ? O TYR A 1094 N TYR A 65  ? N TYR A 1073 
AA1 2 3 N GLY A 66  ? N GLY A 1074 O THR A 143 ? O THR A 1151 
AA1 3 4 O LEU A 142 ? O LEU A 1150 N PHE A 27  ? N PHE A 1035 
AA1 4 5 N THR A 30  ? N THR A 1038 O ASP A 52  ? O ASP A 1060 
AA1 5 6 N ILE A 51  ? N ILE A 1059 O GLY A 102 ? O GLY A 1110 
AA2 1 2 N ASN A 73  ? N ASN A 1081 O ALA A 79  ? O ALA A 1087 
AA3 1 2 O ARG A 224 ? O ARG A 1232 N LEU A 196 ? N LEU A 1204 
AA3 2 3 O PHE A 197 ? O PHE A 1205 N MET A 163 ? N MET A 1171 
AA3 3 4 N ILE A 162 ? N ILE A 1170 O HIS A 263 ? O HIS A 1271 
AA3 4 5 N PHE A 266 ? N PHE A 1274 O GLU A 307 ? O GLU A 1315 
# 
_pdbx_entry_details.entry_id                   9KK7 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 HD21 A ASN 1027 ? ? O  A HOH 1533 ? ? 1.47 
2  1 OE2  A GLU 1053 ? ? H2 A HOH 1528 ? ? 1.51 
3  1 O    A HOH 1654 ? ? H2 A HOH 1793 ? ? 1.52 
4  1 H1   A HOH 1635 ? ? O  A HOH 1852 ? ? 1.54 
5  1 OD1  A ASP 1106 ? ? H2 A HOH 1542 ? ? 1.55 
6  1 O    A ILE 1157 ? ? H1 A HOH 1524 ? ? 1.55 
7  1 O    A TYR 1120 ? ? H2 A HOH 1526 ? ? 1.55 
8  1 OE1  A GLN 1089 ? ? H2 A HOH 1537 ? ? 1.56 
9  1 O    A HOH 1713 ? ? H1 A HOH 1829 ? ? 1.57 
10 1 H2   A HOH 1534 ? ? O  A HOH 1677 ? ? 1.57 
11 1 HE   A ARG 1294 ? ? O  A HOH 1541 ? ? 1.57 
12 1 OG1  A THR 1028 ? ? H2 A HOH 1532 ? ? 1.58 
13 1 HD21 A ASN 1243 ? B O  A HOH 1502 ? ? 1.58 
14 1 O    A GLU 1080 ? ? H1 A HOH 1534 ? ? 1.59 
15 1 H2   A HOH 1680 ? ? O  A HOH 1761 ? ? 1.60 
16 1 O    A GLU 1033 ? ? O  A HOH 1501 ? ? 1.98 
17 1 O    A HOH 1700 ? ? O  A HOH 1883 ? ? 2.10 
18 1 ND2  A ASN 1243 ? B O  A HOH 1502 ? ? 2.14 
19 1 O    A HOH 1834 ? ? O  A HOH 1857 ? ? 2.15 
# 
loop_
_pdbx_validate_symm_contact.id 
_pdbx_validate_symm_contact.PDB_model_num 
_pdbx_validate_symm_contact.auth_atom_id_1 
_pdbx_validate_symm_contact.auth_asym_id_1 
_pdbx_validate_symm_contact.auth_comp_id_1 
_pdbx_validate_symm_contact.auth_seq_id_1 
_pdbx_validate_symm_contact.PDB_ins_code_1 
_pdbx_validate_symm_contact.label_alt_id_1 
_pdbx_validate_symm_contact.site_symmetry_1 
_pdbx_validate_symm_contact.auth_atom_id_2 
_pdbx_validate_symm_contact.auth_asym_id_2 
_pdbx_validate_symm_contact.auth_comp_id_2 
_pdbx_validate_symm_contact.auth_seq_id_2 
_pdbx_validate_symm_contact.PDB_ins_code_2 
_pdbx_validate_symm_contact.label_alt_id_2 
_pdbx_validate_symm_contact.site_symmetry_2 
_pdbx_validate_symm_contact.dist 
1 1 OD2 A ASP 1128 ? ? 1_555 HZ3 A LYS 1147 ? ? 5_445 1.59 
2 1 H2  A HOH 1709 ? ? 1_555 O   A HOH 1753 ? ? 5_545 1.59 
3 1 O   A HOH 1681 ? ? 1_555 H2  A HOH 1847 ? ? 5_445 1.60 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 CB A ASP 1060 ? ? CG A ASP 1060 ? ? OD1 A ASP 1060 ? ? 111.78 118.30 -6.52 0.90 N 
2 1 CB A ASP 1060 ? ? CG A ASP 1060 ? ? OD2 A ASP 1060 ? ? 126.30 118.30 8.00  0.90 N 
3 1 N  A LYS 1302 ? ? CA A LYS 1302 ? ? CB  A LYS 1302 ? ? 121.54 110.60 10.94 1.80 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 LYS A 1084 ? ? -160.91 108.29 
2 1 ASP A 1128 ? ? -166.25 109.43 
3 1 LYS A 1248 ? A -9.47   146.80 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N      N N N 1   
ALA CA     C N S 2   
ALA C      C N N 3   
ALA O      O N N 4   
ALA CB     C N N 5   
ALA OXT    O N N 6   
ALA H      H N N 7   
ALA H2     H N N 8   
ALA HA     H N N 9   
ALA HB1    H N N 10  
ALA HB2    H N N 11  
ALA HB3    H N N 12  
ALA HXT    H N N 13  
ARG N      N N N 14  
ARG CA     C N S 15  
ARG C      C N N 16  
ARG O      O N N 17  
ARG CB     C N N 18  
ARG CG     C N N 19  
ARG CD     C N N 20  
ARG NE     N N N 21  
ARG CZ     C N N 22  
ARG NH1    N N N 23  
ARG NH2    N N N 24  
ARG OXT    O N N 25  
ARG H      H N N 26  
ARG H2     H N N 27  
ARG HA     H N N 28  
ARG HB2    H N N 29  
ARG HB3    H N N 30  
ARG HG2    H N N 31  
ARG HG3    H N N 32  
ARG HD2    H N N 33  
ARG HD3    H N N 34  
ARG HE     H N N 35  
ARG HH11   H N N 36  
ARG HH12   H N N 37  
ARG HH21   H N N 38  
ARG HH22   H N N 39  
ARG HXT    H N N 40  
ASN N      N N N 41  
ASN CA     C N S 42  
ASN C      C N N 43  
ASN O      O N N 44  
ASN CB     C N N 45  
ASN CG     C N N 46  
ASN OD1    O N N 47  
ASN ND2    N N N 48  
ASN OXT    O N N 49  
ASN H      H N N 50  
ASN H2     H N N 51  
ASN HA     H N N 52  
ASN HB2    H N N 53  
ASN HB3    H N N 54  
ASN HD21   H N N 55  
ASN HD22   H N N 56  
ASN HXT    H N N 57  
ASP N      N N N 58  
ASP CA     C N S 59  
ASP C      C N N 60  
ASP O      O N N 61  
ASP CB     C N N 62  
ASP CG     C N N 63  
ASP OD1    O N N 64  
ASP OD2    O N N 65  
ASP OXT    O N N 66  
ASP H      H N N 67  
ASP H2     H N N 68  
ASP HA     H N N 69  
ASP HB2    H N N 70  
ASP HB3    H N N 71  
ASP HD2    H N N 72  
ASP HXT    H N N 73  
CYS N      N N N 74  
CYS CA     C N R 75  
CYS C      C N N 76  
CYS O      O N N 77  
CYS CB     C N N 78  
CYS SG     S N N 79  
CYS OXT    O N N 80  
CYS H      H N N 81  
CYS H2     H N N 82  
CYS HA     H N N 83  
CYS HB2    H N N 84  
CYS HB3    H N N 85  
CYS HG     H N N 86  
CYS HXT    H N N 87  
FDA PA     P N S 88  
FDA O1A    O N N 89  
FDA O2A    O N N 90  
FDA O5B    O N N 91  
FDA C5B    C N N 92  
FDA C4B    C N R 93  
FDA O4B    O N N 94  
FDA C3B    C N S 95  
FDA O3B    O N N 96  
FDA C2B    C N R 97  
FDA O2B    O N N 98  
FDA C1B    C N R 99  
FDA N9A    N Y N 100 
FDA C8A    C Y N 101 
FDA N7A    N Y N 102 
FDA C5A    C Y N 103 
FDA C6A    C Y N 104 
FDA N6A    N N N 105 
FDA N1A    N Y N 106 
FDA C2A    C Y N 107 
FDA N3A    N Y N 108 
FDA C4A    C Y N 109 
FDA N1     N N N 110 
FDA C2     C N N 111 
FDA O2     O N N 112 
FDA N3     N N N 113 
FDA C4     C N N 114 
FDA O4     O N N 115 
FDA C4X    C N N 116 
FDA N5     N N N 117 
FDA C5X    C Y N 118 
FDA C6     C Y N 119 
FDA C7     C Y N 120 
FDA C7M    C N N 121 
FDA C8     C Y N 122 
FDA C8M    C N N 123 
FDA C9     C Y N 124 
FDA C9A    C Y N 125 
FDA N10    N N N 126 
FDA C10    C N N 127 
FDA "C1'"  C N N 128 
FDA "C2'"  C N S 129 
FDA "O2'"  O N N 130 
FDA "C3'"  C N S 131 
FDA "O3'"  O N N 132 
FDA "C4'"  C N R 133 
FDA "O4'"  O N N 134 
FDA "C5'"  C N N 135 
FDA "O5'"  O N N 136 
FDA P      P N R 137 
FDA O1P    O N N 138 
FDA O2P    O N N 139 
FDA O3P    O N N 140 
FDA HOA2   H N N 141 
FDA H51A   H N N 142 
FDA H52A   H N N 143 
FDA H4B    H N N 144 
FDA H3B    H N N 145 
FDA HO3A   H N N 146 
FDA H2B    H N N 147 
FDA HO2A   H N N 148 
FDA H1B    H N N 149 
FDA H8A    H N N 150 
FDA H61A   H N N 151 
FDA H62A   H N N 152 
FDA H2A    H N N 153 
FDA HN1    H N N 154 
FDA HN3    H N N 155 
FDA HN5    H N N 156 
FDA H6     H N N 157 
FDA HM71   H N N 158 
FDA HM72   H N N 159 
FDA HM73   H N N 160 
FDA HM81   H N N 161 
FDA HM82   H N N 162 
FDA HM83   H N N 163 
FDA H9     H N N 164 
FDA "H1'1" H N N 165 
FDA "H1'2" H N N 166 
FDA "H2'"  H N N 167 
FDA "HO2'" H N N 168 
FDA "H3'"  H N N 169 
FDA "HO3'" H N N 170 
FDA "H4'"  H N N 171 
FDA "HO4'" H N N 172 
FDA "H5'1" H N N 173 
FDA "H5'2" H N N 174 
FDA HOP2   H N N 175 
GLN N      N N N 176 
GLN CA     C N S 177 
GLN C      C N N 178 
GLN O      O N N 179 
GLN CB     C N N 180 
GLN CG     C N N 181 
GLN CD     C N N 182 
GLN OE1    O N N 183 
GLN NE2    N N N 184 
GLN OXT    O N N 185 
GLN H      H N N 186 
GLN H2     H N N 187 
GLN HA     H N N 188 
GLN HB2    H N N 189 
GLN HB3    H N N 190 
GLN HG2    H N N 191 
GLN HG3    H N N 192 
GLN HE21   H N N 193 
GLN HE22   H N N 194 
GLN HXT    H N N 195 
GLU N      N N N 196 
GLU CA     C N S 197 
GLU C      C N N 198 
GLU O      O N N 199 
GLU CB     C N N 200 
GLU CG     C N N 201 
GLU CD     C N N 202 
GLU OE1    O N N 203 
GLU OE2    O N N 204 
GLU OXT    O N N 205 
GLU H      H N N 206 
GLU H2     H N N 207 
GLU HA     H N N 208 
GLU HB2    H N N 209 
GLU HB3    H N N 210 
GLU HG2    H N N 211 
GLU HG3    H N N 212 
GLU HE2    H N N 213 
GLU HXT    H N N 214 
GLY N      N N N 215 
GLY CA     C N N 216 
GLY C      C N N 217 
GLY O      O N N 218 
GLY OXT    O N N 219 
GLY H      H N N 220 
GLY H2     H N N 221 
GLY HA2    H N N 222 
GLY HA3    H N N 223 
GLY HXT    H N N 224 
HIS N      N N N 225 
HIS CA     C N S 226 
HIS C      C N N 227 
HIS O      O N N 228 
HIS CB     C N N 229 
HIS CG     C Y N 230 
HIS ND1    N Y N 231 
HIS CD2    C Y N 232 
HIS CE1    C Y N 233 
HIS NE2    N Y N 234 
HIS OXT    O N N 235 
HIS H      H N N 236 
HIS H2     H N N 237 
HIS HA     H N N 238 
HIS HB2    H N N 239 
HIS HB3    H N N 240 
HIS HD1    H N N 241 
HIS HD2    H N N 242 
HIS HE1    H N N 243 
HIS HE2    H N N 244 
HIS HXT    H N N 245 
HOH O      O N N 246 
HOH H1     H N N 247 
HOH H2     H N N 248 
ILE N      N N N 249 
ILE CA     C N S 250 
ILE C      C N N 251 
ILE O      O N N 252 
ILE CB     C N S 253 
ILE CG1    C N N 254 
ILE CG2    C N N 255 
ILE CD1    C N N 256 
ILE OXT    O N N 257 
ILE H      H N N 258 
ILE H2     H N N 259 
ILE HA     H N N 260 
ILE HB     H N N 261 
ILE HG12   H N N 262 
ILE HG13   H N N 263 
ILE HG21   H N N 264 
ILE HG22   H N N 265 
ILE HG23   H N N 266 
ILE HD11   H N N 267 
ILE HD12   H N N 268 
ILE HD13   H N N 269 
ILE HXT    H N N 270 
LEU N      N N N 271 
LEU CA     C N S 272 
LEU C      C N N 273 
LEU O      O N N 274 
LEU CB     C N N 275 
LEU CG     C N N 276 
LEU CD1    C N N 277 
LEU CD2    C N N 278 
LEU OXT    O N N 279 
LEU H      H N N 280 
LEU H2     H N N 281 
LEU HA     H N N 282 
LEU HB2    H N N 283 
LEU HB3    H N N 284 
LEU HG     H N N 285 
LEU HD11   H N N 286 
LEU HD12   H N N 287 
LEU HD13   H N N 288 
LEU HD21   H N N 289 
LEU HD22   H N N 290 
LEU HD23   H N N 291 
LEU HXT    H N N 292 
LYS N      N N N 293 
LYS CA     C N S 294 
LYS C      C N N 295 
LYS O      O N N 296 
LYS CB     C N N 297 
LYS CG     C N N 298 
LYS CD     C N N 299 
LYS CE     C N N 300 
LYS NZ     N N N 301 
LYS OXT    O N N 302 
LYS H      H N N 303 
LYS H2     H N N 304 
LYS HA     H N N 305 
LYS HB2    H N N 306 
LYS HB3    H N N 307 
LYS HG2    H N N 308 
LYS HG3    H N N 309 
LYS HD2    H N N 310 
LYS HD3    H N N 311 
LYS HE2    H N N 312 
LYS HE3    H N N 313 
LYS HZ1    H N N 314 
LYS HZ2    H N N 315 
LYS HZ3    H N N 316 
LYS HXT    H N N 317 
MES O1     O N N 318 
MES C2     C N N 319 
MES C3     C N N 320 
MES N4     N N N 321 
MES C5     C N N 322 
MES C6     C N N 323 
MES C7     C N N 324 
MES C8     C N N 325 
MES S      S N N 326 
MES O1S    O N N 327 
MES O2S    O N N 328 
MES O3S    O N N 329 
MES H21    H N N 330 
MES H22    H N N 331 
MES H31    H N N 332 
MES H32    H N N 333 
MES HN4    H N N 334 
MES H51    H N N 335 
MES H52    H N N 336 
MES H61    H N N 337 
MES H62    H N N 338 
MES H71    H N N 339 
MES H72    H N N 340 
MES H81    H N N 341 
MES H82    H N N 342 
MET N      N N N 343 
MET CA     C N S 344 
MET C      C N N 345 
MET O      O N N 346 
MET CB     C N N 347 
MET CG     C N N 348 
MET SD     S N N 349 
MET CE     C N N 350 
MET OXT    O N N 351 
MET H      H N N 352 
MET H2     H N N 353 
MET HA     H N N 354 
MET HB2    H N N 355 
MET HB3    H N N 356 
MET HG2    H N N 357 
MET HG3    H N N 358 
MET HE1    H N N 359 
MET HE2    H N N 360 
MET HE3    H N N 361 
MET HXT    H N N 362 
PHE N      N N N 363 
PHE CA     C N S 364 
PHE C      C N N 365 
PHE O      O N N 366 
PHE CB     C N N 367 
PHE CG     C Y N 368 
PHE CD1    C Y N 369 
PHE CD2    C Y N 370 
PHE CE1    C Y N 371 
PHE CE2    C Y N 372 
PHE CZ     C Y N 373 
PHE OXT    O N N 374 
PHE H      H N N 375 
PHE H2     H N N 376 
PHE HA     H N N 377 
PHE HB2    H N N 378 
PHE HB3    H N N 379 
PHE HD1    H N N 380 
PHE HD2    H N N 381 
PHE HE1    H N N 382 
PHE HE2    H N N 383 
PHE HZ     H N N 384 
PHE HXT    H N N 385 
PRO N      N N N 386 
PRO CA     C N S 387 
PRO C      C N N 388 
PRO O      O N N 389 
PRO CB     C N N 390 
PRO CG     C N N 391 
PRO CD     C N N 392 
PRO OXT    O N N 393 
PRO H      H N N 394 
PRO HA     H N N 395 
PRO HB2    H N N 396 
PRO HB3    H N N 397 
PRO HG2    H N N 398 
PRO HG3    H N N 399 
PRO HD2    H N N 400 
PRO HD3    H N N 401 
PRO HXT    H N N 402 
SER N      N N N 403 
SER CA     C N S 404 
SER C      C N N 405 
SER O      O N N 406 
SER CB     C N N 407 
SER OG     O N N 408 
SER OXT    O N N 409 
SER H      H N N 410 
SER H2     H N N 411 
SER HA     H N N 412 
SER HB2    H N N 413 
SER HB3    H N N 414 
SER HG     H N N 415 
SER HXT    H N N 416 
THR N      N N N 417 
THR CA     C N S 418 
THR C      C N N 419 
THR O      O N N 420 
THR CB     C N R 421 
THR OG1    O N N 422 
THR CG2    C N N 423 
THR OXT    O N N 424 
THR H      H N N 425 
THR H2     H N N 426 
THR HA     H N N 427 
THR HB     H N N 428 
THR HG1    H N N 429 
THR HG21   H N N 430 
THR HG22   H N N 431 
THR HG23   H N N 432 
THR HXT    H N N 433 
TRP N      N N N 434 
TRP CA     C N S 435 
TRP C      C N N 436 
TRP O      O N N 437 
TRP CB     C N N 438 
TRP CG     C Y N 439 
TRP CD1    C Y N 440 
TRP CD2    C Y N 441 
TRP NE1    N Y N 442 
TRP CE2    C Y N 443 
TRP CE3    C Y N 444 
TRP CZ2    C Y N 445 
TRP CZ3    C Y N 446 
TRP CH2    C Y N 447 
TRP OXT    O N N 448 
TRP H      H N N 449 
TRP H2     H N N 450 
TRP HA     H N N 451 
TRP HB2    H N N 452 
TRP HB3    H N N 453 
TRP HD1    H N N 454 
TRP HE1    H N N 455 
TRP HE3    H N N 456 
TRP HZ2    H N N 457 
TRP HZ3    H N N 458 
TRP HH2    H N N 459 
TRP HXT    H N N 460 
TYR N      N N N 461 
TYR CA     C N S 462 
TYR C      C N N 463 
TYR O      O N N 464 
TYR CB     C N N 465 
TYR CG     C Y N 466 
TYR CD1    C Y N 467 
TYR CD2    C Y N 468 
TYR CE1    C Y N 469 
TYR CE2    C Y N 470 
TYR CZ     C Y N 471 
TYR OH     O N N 472 
TYR OXT    O N N 473 
TYR H      H N N 474 
TYR H2     H N N 475 
TYR HA     H N N 476 
TYR HB2    H N N 477 
TYR HB3    H N N 478 
TYR HD1    H N N 479 
TYR HD2    H N N 480 
TYR HE1    H N N 481 
TYR HE2    H N N 482 
TYR HH     H N N 483 
TYR HXT    H N N 484 
VAL N      N N N 485 
VAL CA     C N S 486 
VAL C      C N N 487 
VAL O      O N N 488 
VAL CB     C N N 489 
VAL CG1    C N N 490 
VAL CG2    C N N 491 
VAL OXT    O N N 492 
VAL H      H N N 493 
VAL H2     H N N 494 
VAL HA     H N N 495 
VAL HB     H N N 496 
VAL HG11   H N N 497 
VAL HG12   H N N 498 
VAL HG13   H N N 499 
VAL HG21   H N N 500 
VAL HG22   H N N 501 
VAL HG23   H N N 502 
VAL HXT    H N N 503 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N     CA     sing N N 1   
ALA N     H      sing N N 2   
ALA N     H2     sing N N 3   
ALA CA    C      sing N N 4   
ALA CA    CB     sing N N 5   
ALA CA    HA     sing N N 6   
ALA C     O      doub N N 7   
ALA C     OXT    sing N N 8   
ALA CB    HB1    sing N N 9   
ALA CB    HB2    sing N N 10  
ALA CB    HB3    sing N N 11  
ALA OXT   HXT    sing N N 12  
ARG N     CA     sing N N 13  
ARG N     H      sing N N 14  
ARG N     H2     sing N N 15  
ARG CA    C      sing N N 16  
ARG CA    CB     sing N N 17  
ARG CA    HA     sing N N 18  
ARG C     O      doub N N 19  
ARG C     OXT    sing N N 20  
ARG CB    CG     sing N N 21  
ARG CB    HB2    sing N N 22  
ARG CB    HB3    sing N N 23  
ARG CG    CD     sing N N 24  
ARG CG    HG2    sing N N 25  
ARG CG    HG3    sing N N 26  
ARG CD    NE     sing N N 27  
ARG CD    HD2    sing N N 28  
ARG CD    HD3    sing N N 29  
ARG NE    CZ     sing N N 30  
ARG NE    HE     sing N N 31  
ARG CZ    NH1    sing N N 32  
ARG CZ    NH2    doub N N 33  
ARG NH1   HH11   sing N N 34  
ARG NH1   HH12   sing N N 35  
ARG NH2   HH21   sing N N 36  
ARG NH2   HH22   sing N N 37  
ARG OXT   HXT    sing N N 38  
ASN N     CA     sing N N 39  
ASN N     H      sing N N 40  
ASN N     H2     sing N N 41  
ASN CA    C      sing N N 42  
ASN CA    CB     sing N N 43  
ASN CA    HA     sing N N 44  
ASN C     O      doub N N 45  
ASN C     OXT    sing N N 46  
ASN CB    CG     sing N N 47  
ASN CB    HB2    sing N N 48  
ASN CB    HB3    sing N N 49  
ASN CG    OD1    doub N N 50  
ASN CG    ND2    sing N N 51  
ASN ND2   HD21   sing N N 52  
ASN ND2   HD22   sing N N 53  
ASN OXT   HXT    sing N N 54  
ASP N     CA     sing N N 55  
ASP N     H      sing N N 56  
ASP N     H2     sing N N 57  
ASP CA    C      sing N N 58  
ASP CA    CB     sing N N 59  
ASP CA    HA     sing N N 60  
ASP C     O      doub N N 61  
ASP C     OXT    sing N N 62  
ASP CB    CG     sing N N 63  
ASP CB    HB2    sing N N 64  
ASP CB    HB3    sing N N 65  
ASP CG    OD1    doub N N 66  
ASP CG    OD2    sing N N 67  
ASP OD2   HD2    sing N N 68  
ASP OXT   HXT    sing N N 69  
CYS N     CA     sing N N 70  
CYS N     H      sing N N 71  
CYS N     H2     sing N N 72  
CYS CA    C      sing N N 73  
CYS CA    CB     sing N N 74  
CYS CA    HA     sing N N 75  
CYS C     O      doub N N 76  
CYS C     OXT    sing N N 77  
CYS CB    SG     sing N N 78  
CYS CB    HB2    sing N N 79  
CYS CB    HB3    sing N N 80  
CYS SG    HG     sing N N 81  
CYS OXT   HXT    sing N N 82  
FDA PA    O1A    doub N N 83  
FDA PA    O2A    sing N N 84  
FDA PA    O5B    sing N N 85  
FDA PA    O3P    sing N N 86  
FDA O2A   HOA2   sing N N 87  
FDA O5B   C5B    sing N N 88  
FDA C5B   C4B    sing N N 89  
FDA C5B   H51A   sing N N 90  
FDA C5B   H52A   sing N N 91  
FDA C4B   O4B    sing N N 92  
FDA C4B   C3B    sing N N 93  
FDA C4B   H4B    sing N N 94  
FDA O4B   C1B    sing N N 95  
FDA C3B   O3B    sing N N 96  
FDA C3B   C2B    sing N N 97  
FDA C3B   H3B    sing N N 98  
FDA O3B   HO3A   sing N N 99  
FDA C2B   O2B    sing N N 100 
FDA C2B   C1B    sing N N 101 
FDA C2B   H2B    sing N N 102 
FDA O2B   HO2A   sing N N 103 
FDA C1B   N9A    sing N N 104 
FDA C1B   H1B    sing N N 105 
FDA N9A   C8A    sing Y N 106 
FDA N9A   C4A    sing Y N 107 
FDA C8A   N7A    doub Y N 108 
FDA C8A   H8A    sing N N 109 
FDA N7A   C5A    sing Y N 110 
FDA C5A   C6A    sing Y N 111 
FDA C5A   C4A    doub Y N 112 
FDA C6A   N6A    sing N N 113 
FDA C6A   N1A    doub Y N 114 
FDA N6A   H61A   sing N N 115 
FDA N6A   H62A   sing N N 116 
FDA N1A   C2A    sing Y N 117 
FDA C2A   N3A    doub Y N 118 
FDA C2A   H2A    sing N N 119 
FDA N3A   C4A    sing Y N 120 
FDA N1    C2     sing N N 121 
FDA N1    C10    sing N N 122 
FDA N1    HN1    sing N N 123 
FDA C2    O2     doub N N 124 
FDA C2    N3     sing N N 125 
FDA N3    C4     sing N N 126 
FDA N3    HN3    sing N N 127 
FDA C4    O4     doub N N 128 
FDA C4    C4X    sing N N 129 
FDA C4X   N5     sing N N 130 
FDA C4X   C10    doub N N 131 
FDA N5    C5X    sing N N 132 
FDA N5    HN5    sing N N 133 
FDA C5X   C6     doub Y N 134 
FDA C5X   C9A    sing Y N 135 
FDA C6    C7     sing Y N 136 
FDA C6    H6     sing N N 137 
FDA C7    C7M    sing N N 138 
FDA C7    C8     doub Y N 139 
FDA C7M   HM71   sing N N 140 
FDA C7M   HM72   sing N N 141 
FDA C7M   HM73   sing N N 142 
FDA C8    C8M    sing N N 143 
FDA C8    C9     sing Y N 144 
FDA C8M   HM81   sing N N 145 
FDA C8M   HM82   sing N N 146 
FDA C8M   HM83   sing N N 147 
FDA C9    C9A    doub Y N 148 
FDA C9    H9     sing N N 149 
FDA C9A   N10    sing N N 150 
FDA N10   C10    sing N N 151 
FDA N10   "C1'"  sing N N 152 
FDA "C1'" "C2'"  sing N N 153 
FDA "C1'" "H1'1" sing N N 154 
FDA "C1'" "H1'2" sing N N 155 
FDA "C2'" "O2'"  sing N N 156 
FDA "C2'" "C3'"  sing N N 157 
FDA "C2'" "H2'"  sing N N 158 
FDA "O2'" "HO2'" sing N N 159 
FDA "C3'" "O3'"  sing N N 160 
FDA "C3'" "C4'"  sing N N 161 
FDA "C3'" "H3'"  sing N N 162 
FDA "O3'" "HO3'" sing N N 163 
FDA "C4'" "O4'"  sing N N 164 
FDA "C4'" "C5'"  sing N N 165 
FDA "C4'" "H4'"  sing N N 166 
FDA "O4'" "HO4'" sing N N 167 
FDA "C5'" "O5'"  sing N N 168 
FDA "C5'" "H5'1" sing N N 169 
FDA "C5'" "H5'2" sing N N 170 
FDA "O5'" P      sing N N 171 
FDA P     O1P    doub N N 172 
FDA P     O2P    sing N N 173 
FDA P     O3P    sing N N 174 
FDA O2P   HOP2   sing N N 175 
GLN N     CA     sing N N 176 
GLN N     H      sing N N 177 
GLN N     H2     sing N N 178 
GLN CA    C      sing N N 179 
GLN CA    CB     sing N N 180 
GLN CA    HA     sing N N 181 
GLN C     O      doub N N 182 
GLN C     OXT    sing N N 183 
GLN CB    CG     sing N N 184 
GLN CB    HB2    sing N N 185 
GLN CB    HB3    sing N N 186 
GLN CG    CD     sing N N 187 
GLN CG    HG2    sing N N 188 
GLN CG    HG3    sing N N 189 
GLN CD    OE1    doub N N 190 
GLN CD    NE2    sing N N 191 
GLN NE2   HE21   sing N N 192 
GLN NE2   HE22   sing N N 193 
GLN OXT   HXT    sing N N 194 
GLU N     CA     sing N N 195 
GLU N     H      sing N N 196 
GLU N     H2     sing N N 197 
GLU CA    C      sing N N 198 
GLU CA    CB     sing N N 199 
GLU CA    HA     sing N N 200 
GLU C     O      doub N N 201 
GLU C     OXT    sing N N 202 
GLU CB    CG     sing N N 203 
GLU CB    HB2    sing N N 204 
GLU CB    HB3    sing N N 205 
GLU CG    CD     sing N N 206 
GLU CG    HG2    sing N N 207 
GLU CG    HG3    sing N N 208 
GLU CD    OE1    doub N N 209 
GLU CD    OE2    sing N N 210 
GLU OE2   HE2    sing N N 211 
GLU OXT   HXT    sing N N 212 
GLY N     CA     sing N N 213 
GLY N     H      sing N N 214 
GLY N     H2     sing N N 215 
GLY CA    C      sing N N 216 
GLY CA    HA2    sing N N 217 
GLY CA    HA3    sing N N 218 
GLY C     O      doub N N 219 
GLY C     OXT    sing N N 220 
GLY OXT   HXT    sing N N 221 
HIS N     CA     sing N N 222 
HIS N     H      sing N N 223 
HIS N     H2     sing N N 224 
HIS CA    C      sing N N 225 
HIS CA    CB     sing N N 226 
HIS CA    HA     sing N N 227 
HIS C     O      doub N N 228 
HIS C     OXT    sing N N 229 
HIS CB    CG     sing N N 230 
HIS CB    HB2    sing N N 231 
HIS CB    HB3    sing N N 232 
HIS CG    ND1    sing Y N 233 
HIS CG    CD2    doub Y N 234 
HIS ND1   CE1    doub Y N 235 
HIS ND1   HD1    sing N N 236 
HIS CD2   NE2    sing Y N 237 
HIS CD2   HD2    sing N N 238 
HIS CE1   NE2    sing Y N 239 
HIS CE1   HE1    sing N N 240 
HIS NE2   HE2    sing N N 241 
HIS OXT   HXT    sing N N 242 
HOH O     H1     sing N N 243 
HOH O     H2     sing N N 244 
ILE N     CA     sing N N 245 
ILE N     H      sing N N 246 
ILE N     H2     sing N N 247 
ILE CA    C      sing N N 248 
ILE CA    CB     sing N N 249 
ILE CA    HA     sing N N 250 
ILE C     O      doub N N 251 
ILE C     OXT    sing N N 252 
ILE CB    CG1    sing N N 253 
ILE CB    CG2    sing N N 254 
ILE CB    HB     sing N N 255 
ILE CG1   CD1    sing N N 256 
ILE CG1   HG12   sing N N 257 
ILE CG1   HG13   sing N N 258 
ILE CG2   HG21   sing N N 259 
ILE CG2   HG22   sing N N 260 
ILE CG2   HG23   sing N N 261 
ILE CD1   HD11   sing N N 262 
ILE CD1   HD12   sing N N 263 
ILE CD1   HD13   sing N N 264 
ILE OXT   HXT    sing N N 265 
LEU N     CA     sing N N 266 
LEU N     H      sing N N 267 
LEU N     H2     sing N N 268 
LEU CA    C      sing N N 269 
LEU CA    CB     sing N N 270 
LEU CA    HA     sing N N 271 
LEU C     O      doub N N 272 
LEU C     OXT    sing N N 273 
LEU CB    CG     sing N N 274 
LEU CB    HB2    sing N N 275 
LEU CB    HB3    sing N N 276 
LEU CG    CD1    sing N N 277 
LEU CG    CD2    sing N N 278 
LEU CG    HG     sing N N 279 
LEU CD1   HD11   sing N N 280 
LEU CD1   HD12   sing N N 281 
LEU CD1   HD13   sing N N 282 
LEU CD2   HD21   sing N N 283 
LEU CD2   HD22   sing N N 284 
LEU CD2   HD23   sing N N 285 
LEU OXT   HXT    sing N N 286 
LYS N     CA     sing N N 287 
LYS N     H      sing N N 288 
LYS N     H2     sing N N 289 
LYS CA    C      sing N N 290 
LYS CA    CB     sing N N 291 
LYS CA    HA     sing N N 292 
LYS C     O      doub N N 293 
LYS C     OXT    sing N N 294 
LYS CB    CG     sing N N 295 
LYS CB    HB2    sing N N 296 
LYS CB    HB3    sing N N 297 
LYS CG    CD     sing N N 298 
LYS CG    HG2    sing N N 299 
LYS CG    HG3    sing N N 300 
LYS CD    CE     sing N N 301 
LYS CD    HD2    sing N N 302 
LYS CD    HD3    sing N N 303 
LYS CE    NZ     sing N N 304 
LYS CE    HE2    sing N N 305 
LYS CE    HE3    sing N N 306 
LYS NZ    HZ1    sing N N 307 
LYS NZ    HZ2    sing N N 308 
LYS NZ    HZ3    sing N N 309 
LYS OXT   HXT    sing N N 310 
MES O1    C2     sing N N 311 
MES O1    C6     sing N N 312 
MES C2    C3     sing N N 313 
MES C2    H21    sing N N 314 
MES C2    H22    sing N N 315 
MES C3    N4     sing N N 316 
MES C3    H31    sing N N 317 
MES C3    H32    sing N N 318 
MES N4    C5     sing N N 319 
MES N4    C7     sing N N 320 
MES N4    HN4    sing N N 321 
MES C5    C6     sing N N 322 
MES C5    H51    sing N N 323 
MES C5    H52    sing N N 324 
MES C6    H61    sing N N 325 
MES C6    H62    sing N N 326 
MES C7    C8     sing N N 327 
MES C7    H71    sing N N 328 
MES C7    H72    sing N N 329 
MES C8    S      sing N N 330 
MES C8    H81    sing N N 331 
MES C8    H82    sing N N 332 
MES S     O1S    doub N N 333 
MES S     O2S    doub N N 334 
MES S     O3S    sing N N 335 
MET N     CA     sing N N 336 
MET N     H      sing N N 337 
MET N     H2     sing N N 338 
MET CA    C      sing N N 339 
MET CA    CB     sing N N 340 
MET CA    HA     sing N N 341 
MET C     O      doub N N 342 
MET C     OXT    sing N N 343 
MET CB    CG     sing N N 344 
MET CB    HB2    sing N N 345 
MET CB    HB3    sing N N 346 
MET CG    SD     sing N N 347 
MET CG    HG2    sing N N 348 
MET CG    HG3    sing N N 349 
MET SD    CE     sing N N 350 
MET CE    HE1    sing N N 351 
MET CE    HE2    sing N N 352 
MET CE    HE3    sing N N 353 
MET OXT   HXT    sing N N 354 
PHE N     CA     sing N N 355 
PHE N     H      sing N N 356 
PHE N     H2     sing N N 357 
PHE CA    C      sing N N 358 
PHE CA    CB     sing N N 359 
PHE CA    HA     sing N N 360 
PHE C     O      doub N N 361 
PHE C     OXT    sing N N 362 
PHE CB    CG     sing N N 363 
PHE CB    HB2    sing N N 364 
PHE CB    HB3    sing N N 365 
PHE CG    CD1    doub Y N 366 
PHE CG    CD2    sing Y N 367 
PHE CD1   CE1    sing Y N 368 
PHE CD1   HD1    sing N N 369 
PHE CD2   CE2    doub Y N 370 
PHE CD2   HD2    sing N N 371 
PHE CE1   CZ     doub Y N 372 
PHE CE1   HE1    sing N N 373 
PHE CE2   CZ     sing Y N 374 
PHE CE2   HE2    sing N N 375 
PHE CZ    HZ     sing N N 376 
PHE OXT   HXT    sing N N 377 
PRO N     CA     sing N N 378 
PRO N     CD     sing N N 379 
PRO N     H      sing N N 380 
PRO CA    C      sing N N 381 
PRO CA    CB     sing N N 382 
PRO CA    HA     sing N N 383 
PRO C     O      doub N N 384 
PRO C     OXT    sing N N 385 
PRO CB    CG     sing N N 386 
PRO CB    HB2    sing N N 387 
PRO CB    HB3    sing N N 388 
PRO CG    CD     sing N N 389 
PRO CG    HG2    sing N N 390 
PRO CG    HG3    sing N N 391 
PRO CD    HD2    sing N N 392 
PRO CD    HD3    sing N N 393 
PRO OXT   HXT    sing N N 394 
SER N     CA     sing N N 395 
SER N     H      sing N N 396 
SER N     H2     sing N N 397 
SER CA    C      sing N N 398 
SER CA    CB     sing N N 399 
SER CA    HA     sing N N 400 
SER C     O      doub N N 401 
SER C     OXT    sing N N 402 
SER CB    OG     sing N N 403 
SER CB    HB2    sing N N 404 
SER CB    HB3    sing N N 405 
SER OG    HG     sing N N 406 
SER OXT   HXT    sing N N 407 
THR N     CA     sing N N 408 
THR N     H      sing N N 409 
THR N     H2     sing N N 410 
THR CA    C      sing N N 411 
THR CA    CB     sing N N 412 
THR CA    HA     sing N N 413 
THR C     O      doub N N 414 
THR C     OXT    sing N N 415 
THR CB    OG1    sing N N 416 
THR CB    CG2    sing N N 417 
THR CB    HB     sing N N 418 
THR OG1   HG1    sing N N 419 
THR CG2   HG21   sing N N 420 
THR CG2   HG22   sing N N 421 
THR CG2   HG23   sing N N 422 
THR OXT   HXT    sing N N 423 
TRP N     CA     sing N N 424 
TRP N     H      sing N N 425 
TRP N     H2     sing N N 426 
TRP CA    C      sing N N 427 
TRP CA    CB     sing N N 428 
TRP CA    HA     sing N N 429 
TRP C     O      doub N N 430 
TRP C     OXT    sing N N 431 
TRP CB    CG     sing N N 432 
TRP CB    HB2    sing N N 433 
TRP CB    HB3    sing N N 434 
TRP CG    CD1    doub Y N 435 
TRP CG    CD2    sing Y N 436 
TRP CD1   NE1    sing Y N 437 
TRP CD1   HD1    sing N N 438 
TRP CD2   CE2    doub Y N 439 
TRP CD2   CE3    sing Y N 440 
TRP NE1   CE2    sing Y N 441 
TRP NE1   HE1    sing N N 442 
TRP CE2   CZ2    sing Y N 443 
TRP CE3   CZ3    doub Y N 444 
TRP CE3   HE3    sing N N 445 
TRP CZ2   CH2    doub Y N 446 
TRP CZ2   HZ2    sing N N 447 
TRP CZ3   CH2    sing Y N 448 
TRP CZ3   HZ3    sing N N 449 
TRP CH2   HH2    sing N N 450 
TRP OXT   HXT    sing N N 451 
TYR N     CA     sing N N 452 
TYR N     H      sing N N 453 
TYR N     H2     sing N N 454 
TYR CA    C      sing N N 455 
TYR CA    CB     sing N N 456 
TYR CA    HA     sing N N 457 
TYR C     O      doub N N 458 
TYR C     OXT    sing N N 459 
TYR CB    CG     sing N N 460 
TYR CB    HB2    sing N N 461 
TYR CB    HB3    sing N N 462 
TYR CG    CD1    doub Y N 463 
TYR CG    CD2    sing Y N 464 
TYR CD1   CE1    sing Y N 465 
TYR CD1   HD1    sing N N 466 
TYR CD2   CE2    doub Y N 467 
TYR CD2   HD2    sing N N 468 
TYR CE1   CZ     doub Y N 469 
TYR CE1   HE1    sing N N 470 
TYR CE2   CZ     sing Y N 471 
TYR CE2   HE2    sing N N 472 
TYR CZ    OH     sing N N 473 
TYR OH    HH     sing N N 474 
TYR OXT   HXT    sing N N 475 
VAL N     CA     sing N N 476 
VAL N     H      sing N N 477 
VAL N     H2     sing N N 478 
VAL CA    C      sing N N 479 
VAL CA    CB     sing N N 480 
VAL CA    HA     sing N N 481 
VAL C     O      doub N N 482 
VAL C     OXT    sing N N 483 
VAL CB    CG1    sing N N 484 
VAL CB    CG2    sing N N 485 
VAL CB    HB     sing N N 486 
VAL CG1   HG11   sing N N 487 
VAL CG1   HG12   sing N N 488 
VAL CG1   HG13   sing N N 489 
VAL CG2   HG21   sing N N 490 
VAL CG2   HG22   sing N N 491 
VAL CG2   HG23   sing N N 492 
VAL OXT   HXT    sing N N 493 
# 
_pdbx_audit_support.funding_organization   'Japan Science and Technology' 
_pdbx_audit_support.country                Japan 
_pdbx_audit_support.grant_number           JPMJSP2138 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5h59 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9KK7 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.016858 
_atom_sites.fract_transf_matrix[1][2]   0.009733 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.019466 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.005328 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
C 6  6  0.6650  0.0000 
D 1  1  0.6670  0.0000 
H 1  1  -0.3740 0.0000 
N 7  7  0.9360  0.0000 
O 8  8  0.5810  0.0000 
P 15 15 0.5130  0.0000 
S 16 16 0.2847  0.0000 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N N      . SER A 1 1   ? 37.72   -7.358  21.113  1    42.703 ? 1009 SER A N      1 ? 
ATOM   2    C CA     . SER A 1 1   ? 36.375  -7.268  21.743  1    40.85  ? 1009 SER A CA     1 ? 
ATOM   3    C C      . SER A 1 1   ? 35.522  -8.534  21.531  1    33.905 ? 1009 SER A C      1 ? 
ATOM   4    O O      . SER A 1 1   ? 34.356  -8.524  21.934  1    33.853 ? 1009 SER A O      1 ? 
ATOM   5    C CB     . SER A 1 1   ? 35.631  -6.041  21.266  1    40.578 ? 1009 SER A CB     1 ? 
ATOM   6    O OG     . SER A 1 1   ? 35.129  -6.248  19.951  1    41.975 ? 1009 SER A OG     1 ? 
ATOM   7    N N      . LYS A 1 2   ? 36.069  -9.638  20.984  1    25.377 ? 1010 LYS A N      1 ? 
ATOM   8    C CA     . LYS A 1 2   ? 35.27   -10.86  20.909  1    23.997 ? 1010 LYS A CA     1 ? 
ATOM   9    C C      . LYS A 1 2   ? 35.243  -11.541 22.278  1    24.184 ? 1010 LYS A C      1 ? 
ATOM   10   O O      . LYS A 1 2   ? 36.237  -11.528 23.02   1    26.763 ? 1010 LYS A O      1 ? 
ATOM   11   C CB     . LYS A 1 2   ? 35.761  -11.868 19.867  1    19.542 ? 1010 LYS A CB     1 ? 
ATOM   12   C CG     . LYS A 1 2   ? 35.48   -11.472 18.436  1    19.943 ? 1010 LYS A CG     1 ? 
ATOM   13   C CD     . LYS A 1 2   ? 35.966  -12.533 17.468  1    19.791 ? 1010 LYS A CD     1 ? 
ATOM   14   C CE     . LYS A 1 2   ? 36.159  -12.12  16.057  1    19.459 ? 1010 LYS A CE     1 ? 
ATOM   15   N NZ     . LYS A 1 2   ? 34.889  -12.025 15.347  1    20.634 ? 1010 LYS A NZ     1 ? 
ATOM   16   H H      . LYS A 1 2   ? 37.067  -9.701  20.724  1    26.274 ? 1010 LYS A H      1 ? 
ATOM   17   H HA     . LYS A 1 2   ? 34.248  -10.58  20.646  1    23.401 ? 1010 LYS A HA     1 c 
ATOM   18   H HB2    . LYS A 1 2   ? 36.838  -11.999 19.985  1    20.522 ? 1010 LYS A HB2    1 c 
ATOM   19   H HB3    . LYS A 1 2   ? 35.286  -12.832 20.06   1    20.505 ? 1010 LYS A HB3    1 c 
ATOM   20   H HG2    . LYS A 1 2   ? 34.405  -11.33  18.31   1    19.821 ? 1010 LYS A HG2    1 c 
ATOM   21   H HG3    . LYS A 1 2   ? 35.983  -10.527 18.223  1    19.821 ? 1010 LYS A HG3    1 c 
ATOM   22   H HD2    . LYS A 1 2   ? 36.914  -12.923 17.845  1    19.732 ? 1010 LYS A HD2    1 c 
ATOM   23   H HD3    . LYS A 1 2   ? 35.256  -13.36  17.49   1    19.663 ? 1010 LYS A HD3    1 c 
ATOM   24   H HE2    . LYS A 1 2   ? 36.656  -11.148 16.026  1    19.792 ? 1010 LYS A HE2    1 c 
ATOM   25   H HE3    . LYS A 1 2   ? 36.797  -12.845 15.548  1    19.792 ? 1010 LYS A HE3    1 c 
ATOM   26   H HZ1    . LYS A 1 2   ? 35.14   -12.317 14.403  1    20.187 ? 1010 LYS A HZ1    1 ? 
ATOM   27   H HZ2    . LYS A 1 2   ? 34.121  -12.625 15.711  1    20.216 ? 1010 LYS A HZ2    1 ? 
ATOM   28   H HZ3    . LYS A 1 2   ? 34.51   -11.076 15.417  1    19.392 ? 1010 LYS A HZ3    1 ? 
ATOM   29   N N      . VAL A 1 3   ? 34.081  -12.105 22.624  1    19.675 ? 1011 VAL A N      1 ? 
ATOM   30   C CA     . VAL A 1 3   ? 33.8    -12.622 23.952  1    17.989 ? 1011 VAL A CA     1 ? 
ATOM   31   C C      . VAL A 1 3   ? 34.378  -14.023 24.08   1    16.409 ? 1011 VAL A C      1 ? 
ATOM   32   O O      . VAL A 1 3   ? 34.161  -14.888 23.235  1    13.961 ? 1011 VAL A O      1 ? 
ATOM   33   C CB     . VAL A 1 3   ? 32.277  -12.659 24.175  1    19.181 ? 1011 VAL A CB     1 ? 
ATOM   34   C CG1    . VAL A 1 3   ? 31.905  -13.322 25.497  1    22.004 ? 1011 VAL A CG1    1 ? 
ATOM   35   C CG2    . VAL A 1 3   ? 31.667  -11.267 24.046  1    19.1   ? 1011 VAL A CG2    1 ? 
ATOM   36   H H      . VAL A 1 3   ? 33.366  -12.215 21.885  1    20.176 ? 1011 VAL A H      1 ? 
ATOM   37   H HA     . VAL A 1 3   ? 34.26   -11.97  24.696  1    18.201 ? 1011 VAL A HA     1 c 
ATOM   38   H HB     . VAL A 1 3   ? 31.855  -13.273 23.376  1    19.424 ? 1011 VAL A HB     1 c 
ATOM   39   H HG11   . VAL A 1 3   ? 30.831  -13.22  25.665  1    21.145 ? 1011 VAL A HG11   1 c 
ATOM   40   H HG12   . VAL A 1 3   ? 32.166  -14.382 25.463  1    21.108 ? 1011 VAL A HG12   1 c 
ATOM   41   H HG13   . VAL A 1 3   ? 32.447  -12.839 26.312  1    21.071 ? 1011 VAL A HG13   1 c 
ATOM   42   H HG21   . VAL A 1 3   ? 30.592  -11.322 24.231  1    19.116 ? 1011 VAL A HG21   1 c 
ATOM   43   H HG22   . VAL A 1 3   ? 32.127  -10.598 24.776  1    19.116 ? 1011 VAL A HG22   1 c 
ATOM   44   H HG23   . VAL A 1 3   ? 31.843  -10.883 23.039  1    19.094 ? 1011 VAL A HG23   1 c 
ATOM   45   N N      . SER A 1 4   ? 35.096  -14.265 25.181  1    15.476 ? 1012 SER A N      1 ? 
ATOM   46   C CA     . SER A 1 4   ? 35.628  -15.59  25.437  1    15.975 ? 1012 SER A CA     1 ? 
ATOM   47   C C      . SER A 1 4   ? 34.485  -16.585 25.628  1    14.77  ? 1012 SER A C      1 ? 
ATOM   48   O O      . SER A 1 4   ? 33.546  -16.333 26.396  1    18.208 ? 1012 SER A O      1 ? 
ATOM   49   C CB     . SER A 1 4   ? 36.569  -15.643 26.658  1    17.785 ? 1012 SER A CB     1 ? 
ATOM   50   O OG     . SER A 1 4   ? 37.763  -14.914 26.351  1    19.269 ? 1012 SER A OG     1 ? 
ATOM   51   H H      . SER A 1 4   ? 35.129  -13.571 25.934  1    17.063 ? 1012 SER A H      1 ? 
ATOM   52   H HA     . SER A 1 4   ? 36.197  -15.896 24.557  1    15.943 ? 1012 SER A HA     1 c 
ATOM   53   H HB2    . SER A 1 4   ? 36.075  -15.199 27.524  1    17.769 ? 1012 SER A HB2    1 c 
ATOM   54   H HB3    . SER A 1 4   ? 36.818  -16.682 26.887  1    17.721 ? 1012 SER A HB3    1 c 
ATOM   55   H HG     . SER A 1 4   ? 37.532  -13.988 26.154  1    18.629 ? 1012 SER A HG     1 ? 
ATOM   56   N N      . VAL A 1 5   ? 34.568  -17.72  24.941  1    14.243 ? 1013 VAL A N      1 ? 
ATOM   57   C CA     . VAL A 1 5   ? 33.591  -18.792 25.08   1    15.483 ? 1013 VAL A CA     1 ? 
ATOM   58   C C      . VAL A 1 5   ? 34.333  -20.054 25.495  1    14.947 ? 1013 VAL A C      1 ? 
ATOM   59   O O      . VAL A 1 5   ? 35.507  -20.249 25.154  1    18.107 ? 1013 VAL A O      1 ? 
ATOM   60   C CB     . VAL A 1 5   ? 32.807  -19.039 23.775  1    15.001 ? 1013 VAL A CB     1 ? 
ATOM   61   C CG1    . VAL A 1 5   ? 31.898  -17.877 23.482  1    16.347 ? 1013 VAL A CG1    1 ? 
ATOM   62   C CG2    . VAL A 1 5   ? 33.732  -19.31  22.598  1    15.356 ? 1013 VAL A CG2    1 ? 
ATOM   63   H H      . VAL A 1 5   ? 35.357  -17.872 24.29   1    14.164 ? 1013 VAL A H      1 ? 
ATOM   64   H HA     . VAL A 1 5   ? 32.886  -18.525 25.868  1    15.08  ? 1013 VAL A HA     1 c 
ATOM   65   H HB     . VAL A 1 5   ? 32.188  -19.923 23.933  1    15.36  ? 1013 VAL A HB     1 c 
ATOM   66   H HG11   . VAL A 1 5   ? 31.198  -17.745 24.309  1    15.943 ? 1013 VAL A HG11   1 c 
ATOM   67   H HG12   . VAL A 1 5   ? 32.493  -16.969 23.361  1    15.947 ? 1013 VAL A HG12   1 c 
ATOM   68   H HG13   . VAL A 1 5   ? 31.342  -18.072 22.563  1    15.919 ? 1013 VAL A HG13   1 c 
ATOM   69   H HG21   . VAL A 1 5   ? 34.4    -18.459 22.454  1    15.241 ? 1013 VAL A HG21   1 c 
ATOM   70   H HG22   . VAL A 1 5   ? 34.323  -20.207 22.795  1    15.252 ? 1013 VAL A HG22   1 c 
ATOM   71   H HG23   . VAL A 1 5   ? 33.137  -19.461 21.695  1    15.256 ? 1013 VAL A HG23   1 c 
ATOM   72   N N      . ALA A 1 6   ? 33.629  -20.929 26.201  1    14.757 ? 1014 ALA A N      1 ? 
ATOM   73   C CA     . ALA A 1 6   ? 34.174  -22.191 26.659  1    15.247 ? 1014 ALA A CA     1 ? 
ATOM   74   C C      . ALA A 1 6   ? 33.055  -23.212 26.666  1    15.88  ? 1014 ALA A C      1 ? 
ATOM   75   O O      . ALA A 1 6   ? 31.888  -22.841 26.825  1    17.131 ? 1014 ALA A O      1 ? 
ATOM   76   C CB     . ALA A 1 6   ? 34.753  -22.053 28.066  1    15.828 ? 1014 ALA A CB     1 ? 
ATOM   77   H H      . ALA A 1 6   ? 32.696  -20.642 26.524  1    14.809 ? 1014 ALA A H      1 ? 
ATOM   78   H HA     . ALA A 1 6   ? 34.951  -22.516 25.964  1    15.373 ? 1014 ALA A HA     1 c 
ATOM   79   H HB1    . ALA A 1 6   ? 33.969  -21.732 28.756  1    15.657 ? 1014 ALA A HB1    1 c 
ATOM   80   H HB2    . ALA A 1 6   ? 35.151  -23.015 28.396  1    15.652 ? 1014 ALA A HB2    1 c 
ATOM   81   H HB3    . ALA A 1 6   ? 35.556  -21.313 28.063  1    15.637 ? 1014 ALA A HB3    1 c 
ATOM   82   N N      . PRO A 1 7   ? 33.374  -24.513 26.552  1    14.894 ? 1015 PRO A N      1 ? 
ATOM   83   C CA     . PRO A 1 7   ? 34.709  -25.065 26.329  1    14.881 ? 1015 PRO A CA     1 ? 
ATOM   84   C C      . PRO A 1 7   ? 34.993  -25.252 24.85   1    15.319 ? 1015 PRO A C      1 ? 
ATOM   85   O O      . PRO A 1 7   ? 34.12   -25.668 24.09   1    15.054 ? 1015 PRO A O      1 ? 
ATOM   86   C CB     . PRO A 1 7   ? 34.619  -26.419 27.026  1    15.103 ? 1015 PRO A CB     1 ? 
ATOM   87   C CG     . PRO A 1 7   ? 33.183  -26.835 26.808  1    14.79  ? 1015 PRO A CG     1 ? 
ATOM   88   C CD     . PRO A 1 7   ? 32.368  -25.562 26.764  1    15.151 ? 1015 PRO A CD     1 ? 
ATOM   89   H HA     . PRO A 1 7   ? 35.47   -24.434 26.792  1    15.008 ? 1015 PRO A HA     1 c 
ATOM   90   H HB2    . PRO A 1 7   ? 35.308  -27.136 26.575  1    14.992 ? 1015 PRO A HB2    1 c 
ATOM   91   H HB3    . PRO A 1 7   ? 34.843  -26.326 28.091  1    14.988 ? 1015 PRO A HB3    1 c 
ATOM   92   H HG2    . PRO A 1 7   ? 33.08   -27.383 25.869  1    14.935 ? 1015 PRO A HG2    1 c 
ATOM   93   H HG3    . PRO A 1 7   ? 32.841  -27.476 27.623  1    14.935 ? 1015 PRO A HG3    1 c 
ATOM   94   H HD2    . PRO A 1 7   ? 31.65   -25.579 25.942  1    15.016 ? 1015 PRO A HD2    1 c 
ATOM   95   H HD3    . PRO A 1 7   ? 31.835  -25.401 27.704  1    15.016 ? 1015 PRO A HD3    1 c 
ATOM   96   N N      . LEU A 1 8   ? 36.222  -24.962 24.441  1    14.404 ? 1016 LEU A N      1 ? 
ATOM   97   C CA     . LEU A 1 8   ? 36.536  -25.017 23.018  1    13.477 ? 1016 LEU A CA     1 ? 
ATOM   98   C C      . LEU A 1 8   ? 36.491  -26.438 22.453  1    12.208 ? 1016 LEU A C      1 ? 
ATOM   99   O O      . LEU A 1 8   ? 36.437  -26.59  21.231  1    11.597 ? 1016 LEU A O      1 ? 
ATOM   100  C CB     . LEU A 1 8   ? 37.856  -24.29  22.743  1    15.253 ? 1016 LEU A CB     1 ? 
ATOM   101  C CG     . LEU A 1 8   ? 37.699  -22.759 22.719  1    19.137 ? 1016 LEU A CG     1 ? 
ATOM   102  C CD1    . LEU A 1 8   ? 39.013  -22.043 22.534  1    19.803 ? 1016 LEU A CD1    1 ? 
ATOM   103  C CD2    . LEU A 1 8   ? 36.709  -22.253 21.631  1    20.677 ? 1016 LEU A CD2    1 ? 
ATOM   104  H H      . LEU A 1 8   ? 36.913  -24.606 25.123  1    14.041 ? 1016 LEU A H      1 ? 
ATOM   105  H HA     . LEU A 1 8   ? 35.744  -24.469 22.507  1    13.79  ? 1016 LEU A HA     1 c 
ATOM   106  H HB2    . LEU A 1 8   ? 38.571  -24.559 23.524  1    15.596 ? 1016 LEU A HB2    1 c 
ATOM   107  H HB3    . LEU A 1 8   ? 38.24   -24.62  21.775  1    15.596 ? 1016 LEU A HB3    1 c 
ATOM   108  H HG     . LEU A 1 8   ? 37.298  -22.453 23.688  1    18.743 ? 1016 LEU A HG     1 c 
ATOM   109  H HD11   . LEU A 1 8   ? 38.844  -20.964 22.527  1    19.582 ? 1016 LEU A HD11   1 c 
ATOM   110  H HD12   . LEU A 1 8   ? 39.687  -22.299 23.354  1    19.582 ? 1016 LEU A HD12   1 c 
ATOM   111  H HD13   . LEU A 1 8   ? 39.464  -22.346 21.587  1    19.479 ? 1016 LEU A HD13   1 c 
ATOM   112  H HD21   . LEU A 1 8   ? 37.008  -22.643 20.656  1    20.201 ? 1016 LEU A HD21   1 c 
ATOM   113  H HD22   . LEU A 1 8   ? 35.7    -22.597 21.866  1    20.142 ? 1016 LEU A HD22   1 c 
ATOM   114  H HD23   . LEU A 1 8   ? 36.722  -21.162 21.606  1    20.126 ? 1016 LEU A HD23   1 c 
ATOM   115  N N      . HIS A 1 9   ? 36.433  -27.474 23.295  1    13.064 ? 1017 HIS A N      1 ? 
ATOM   116  C CA     . HIS A 1 9   ? 36.226  -28.82  22.786  1    15.212 ? 1017 HIS A CA     1 ? 
ATOM   117  C C      . HIS A 1 9   ? 34.894  -28.979 22.052  1    15.432 ? 1017 HIS A C      1 ? 
ATOM   118  O O      . HIS A 1 9   ? 34.736  -29.963 21.332  1    17.344 ? 1017 HIS A O      1 ? 
ATOM   119  C CB     . HIS A 1 9   ? 36.414  -29.899 23.87   1    15.688 ? 1017 HIS A CB     1 ? 
ATOM   120  C CG     . HIS A 1 9   ? 35.347  -29.964 24.912  1    16.889 ? 1017 HIS A CG     1 ? 
ATOM   121  N ND1    . HIS A 1 9   ? 35.579  -29.654 26.236  1    15.981 ? 1017 HIS A ND1    1 ? 
ATOM   122  C CD2    . HIS A 1 9   ? 34.053  -30.374 24.861  1    17.019 ? 1017 HIS A CD2    1 ? 
ATOM   123  C CE1    . HIS A 1 9   ? 34.47   -29.855 26.947  1    16.608 ? 1017 HIS A CE1    1 ? 
ATOM   124  N NE2    . HIS A 1 9   ? 33.524  -30.282 26.124  1    17.3   ? 1017 HIS A NE2    1 ? 
ATOM   125  H H      . HIS A 1 9   ? 36.611  -27.344 24.301  1    13.273 ? 1017 HIS A H      1 ? 
ATOM   126  H HA     . HIS A 1 9   ? 37.019  -28.982 22.054  1    14.869 ? 1017 HIS A HA     1 c 
ATOM   127  H HB2    . HIS A 1 9   ? 36.48   -30.872 23.379  1    15.843 ? 1017 HIS A HB2    1 c 
ATOM   128  H HB3    . HIS A 1 9   ? 37.372  -29.727 24.363  1    15.843 ? 1017 HIS A HB3    1 c 
ATOM   129  H HD1    . HIS A 1 9   ? 36.465  -29.317 26.604  1    17.614 ? 1017 HIS A HD1    1 ? 
ATOM   130  H HD2    . HIS A 1 9   ? 33.512  -30.691 23.975  1    17.047 ? 1017 HIS A HD2    1 c 
ATOM   131  H HE1    . HIS A 1 9   ? 34.35   -29.65  28.005  1    16.638 ? 1017 HIS A HE1    1 c 
ATOM   132  H HE2    . HIS A 1 9   ? 32.57   -30.45  26.356  1    18.627 ? 1017 HIS A HE2    1 ? 
ATOM   133  N N      . LEU A 1 10  ? 33.971  -28.026 22.174  1    15.037 ? 1018 LEU A N      1 ? 
ATOM   134  C CA     . LEU A 1 10  ? 32.759  -28.068 21.358  1    16.098 ? 1018 LEU A CA     1 ? 
ATOM   135  C C      . LEU A 1 10  ? 33.051  -27.927 19.866  1    14.358 ? 1018 LEU A C      1 ? 
ATOM   136  O O      . LEU A 1 10  ? 32.173  -28.207 19.048  1    14.275 ? 1018 LEU A O      1 ? 
ATOM   137  C CB     . LEU A 1 10  ? 31.759  -27.004 21.813  1    15.091 ? 1018 LEU A CB     1 ? 
ATOM   138  C CG     . LEU A 1 10  ? 31.191  -27.199 23.217  1    15.045 ? 1018 LEU A CG     1 ? 
ATOM   139  C CD1    . LEU A 1 10  ? 30.129  -26.155 23.48   1    15.186 ? 1018 LEU A CD1    1 ? 
ATOM   140  C CD2    . LEU A 1 10  ? 30.661  -28.594 23.45   1    14.145 ? 1018 LEU A CD2    1 ? 
ATOM   141  H H      . LEU A 1 10  ? 34.124  -27.239 22.825  1    14.95  ? 1018 LEU A H      1 ? 
ATOM   142  H HA     . LEU A 1 10  ? 32.306  -29.05  21.503  1    15.386 ? 1018 LEU A HA     1 c 
ATOM   143  H HB2    . LEU A 1 10  ? 32.254  -26.031 21.773  1    15.295 ? 1018 LEU A HB2    1 c 
ATOM   144  H HB3    . LEU A 1 10  ? 30.93   -26.989 21.103  1    15.295 ? 1018 LEU A HB3    1 c 
ATOM   145  H HG     . LEU A 1 10  ? 31.999  -27.032 23.931  1    14.911 ? 1018 LEU A HG     1 c 
ATOM   146  H HD11   . LEU A 1 10  ? 29.719  -26.296 24.482  1    15.142 ? 1018 LEU A HD11   1 c 
ATOM   147  H HD12   . LEU A 1 10  ? 30.569  -25.159 23.406  1    15.129 ? 1018 LEU A HD12   1 c 
ATOM   148  H HD13   . LEU A 1 10  ? 29.328  -26.254 22.744  1    15.141 ? 1018 LEU A HD13   1 c 
ATOM   149  H HD21   . LEU A 1 10  ? 30.185  -28.644 24.432  1    14.399 ? 1018 LEU A HD21   1 c 
ATOM   150  H HD22   . LEU A 1 10  ? 29.928  -28.839 22.679  1    14.399 ? 1018 LEU A HD22   1 c 
ATOM   151  H HD23   . LEU A 1 10  ? 31.484  -29.31  23.41   1    14.425 ? 1018 LEU A HD23   1 c 
ATOM   152  N N      . GLU A 1 11  ? 34.246  -27.455 19.502  1    15.194 ? 1019 GLU A N      1 ? 
ATOM   153  C CA     . GLU A 1 11  ? 34.632  -27.354 18.101  1    13.335 ? 1019 GLU A CA     1 ? 
ATOM   154  C C      . GLU A 1 11  ? 35.174  -28.663 17.54   1    14.146 ? 1019 GLU A C      1 ? 
ATOM   155  O O      . GLU A 1 11  ? 35.354  -28.763 16.321  1    13.199 ? 1019 GLU A O      1 ? 
ATOM   156  C CB     . GLU A 1 11  ? 35.689  -26.275 17.923  1    14.14  ? 1019 GLU A CB     1 ? 
ATOM   157  C CG     . GLU A 1 11  ? 35.232  -24.896 18.363  1    15.076 ? 1019 GLU A CG     1 ? 
ATOM   158  C CD     . GLU A 1 11  ? 34.095  -24.349 17.525  1    14.282 ? 1019 GLU A CD     1 ? 
ATOM   159  O OE1    . GLU A 1 11  ? 34.084  -24.574 16.293  1    14.612 ? 1019 GLU A OE1    1 ? 
ATOM   160  O OE2    . GLU A 1 11  ? 33.223  -23.664 18.11   1    13.906 ? 1019 GLU A OE2    1 ? 
ATOM   161  H H      . GLU A 1 11  ? 34.939  -27.218 20.237  1    13.765 ? 1019 GLU A H      1 ? 
ATOM   162  H HA     . GLU A 1 11  ? 33.749  -27.072 17.524  1    13.959 ? 1019 GLU A HA     1 c 
ATOM   163  H HB2    . GLU A 1 11  ? 36.575  -26.555 18.497  1    14.263 ? 1019 GLU A HB2    1 c 
ATOM   164  H HB3    . GLU A 1 11  ? 35.976  -26.235 16.87   1    14.18  ? 1019 GLU A HB3    1 c 
ATOM   165  H HG2    . GLU A 1 11  ? 34.91   -24.942 19.404  1    14.713 ? 1019 GLU A HG2    1 c 
ATOM   166  H HG3    . GLU A 1 11  ? 36.074  -24.203 18.306  1    14.716 ? 1019 GLU A HG3    1 c 
ATOM   167  N N      . SER A 1 12  ? 35.424  -29.668 18.388  1    15.003 ? 1020 SER A N      1 ? 
ATOM   168  C CA     . SER A 1 12  ? 36.15   -30.847 17.927  1    17.576 ? 1020 SER A CA     1 ? 
ATOM   169  C C      . SER A 1 12  ? 35.299  -31.792 17.071  1    20.362 ? 1020 SER A C      1 ? 
ATOM   170  O O      . SER A 1 12  ? 35.808  -32.406 16.136  1    22.197 ? 1020 SER A O      1 ? 
ATOM   171  C CB     . SER A 1 12  ? 36.771  -31.619 19.077  1    18.084 ? 1020 SER A CB     1 ? 
ATOM   172  O OG     . SER A 1 12  ? 37.562  -30.771 19.904  1    18.711 ? 1020 SER A OG     1 ? 
ATOM   173  H H      . SER A 1 12  ? 35.234  -29.573 19.402  1    16.016 ? 1020 SER A H      1 ? 
ATOM   174  H HA     . SER A 1 12  ? 36.967  -30.491 17.297  1    17.569 ? 1020 SER A HA     1 c 
ATOM   175  H HB2    . SER A 1 12  ? 35.978  -32.072 19.677  1    18.116 ? 1020 SER A HB2    1 c 
ATOM   176  H HB3    . SER A 1 12  ? 37.396  -32.421 18.678  1    18.116 ? 1020 SER A HB3    1 c 
ATOM   177  H HG     . SER A 1 12  ? 38.443  -30.682 19.494  1    17.662 ? 1020 SER A HG     1 ? 
ATOM   178  N N      . ALA A 1 13  ? 34.015  -31.938 17.398  1    20.007 ? 1021 ALA A N      1 ? 
ATOM   179  C CA     . ALA A 1 13  ? 33.171  -32.868 16.678  1    20.315 ? 1021 ALA A CA     1 ? 
ATOM   180  C C      . ALA A 1 13  ? 33.129  -32.535 15.188  1    20.667 ? 1021 ALA A C      1 ? 
ATOM   181  O O      . ALA A 1 13  ? 33.016  -31.374 14.808  1    22.399 ? 1021 ALA A O      1 ? 
ATOM   182  C CB     . ALA A 1 13  ? 31.764  -32.85  17.26   1    22.222 ? 1021 ALA A CB     1 ? 
ATOM   183  H H      . ALA A 1 13  ? 33.637  -31.387 18.193  1    22.324 ? 1021 ALA A H      1 ? 
ATOM   184  H HA     . ALA A 1 13  ? 33.592  -33.869 16.792  1    20.664 ? 1021 ALA A HA     1 c 
ATOM   185  H HB1    . ALA A 1 13  ? 31.79   -33.199 18.294  1    21.69  ? 1021 ALA A HB1    1 c 
ATOM   186  H HB2    . ALA A 1 13  ? 31.367  -31.833 17.232  1    21.673 ? 1021 ALA A HB2    1 c 
ATOM   187  H HB3    . ALA A 1 13  ? 31.117  -33.507 16.675  1    21.648 ? 1021 ALA A HB3    1 c 
ATOM   188  N N      . LYS A 1 14  ? 33.208  -33.57  14.354  1    24.089 ? 1022 LYS A N      1 ? 
ATOM   189  C CA     . LYS A 1 14  ? 33.237  -33.364 12.911  1    28.086 ? 1022 LYS A CA     1 ? 
ATOM   190  C C      . LYS A 1 14  ? 31.846  -33.456 12.27   1    23.946 ? 1022 LYS A C      1 ? 
ATOM   191  O O      . LYS A 1 14  ? 31.708  -33.094 11.106  1    21.44  ? 1022 LYS A O      1 ? 
ATOM   192  C CB     . LYS A 1 14  ? 34.23   -34.317 12.224  1    38.224 ? 1022 LYS A CB     1 ? 
ATOM   193  C CG     . LYS A 1 14  ? 35.659  -33.906 12.627  1    48.192 ? 1022 LYS A CG     1 ? 
ATOM   194  C CD     . LYS A 1 14  ? 36.86   -34.547 11.937  1    55.929 ? 1022 LYS A CD     1 ? 
ATOM   195  C CE     . LYS A 1 14  ? 38.063  -33.725 12.297  1    62.709 ? 1022 LYS A CE     1 ? 
ATOM   196  N NZ     . LYS A 1 14  ? 39.304  -34.437 11.995  1    72.918 ? 1022 LYS A NZ     1 ? 
ATOM   197  H H      . LYS A 1 14  ? 33.322  -34.52  14.741  1    23.544 ? 1022 LYS A H      1 ? 
ATOM   198  H HA     . LYS A 1 14  ? 33.61   -32.353 12.732  1    27.954 ? 1022 LYS A HA     1 c 
ATOM   199  H HB2    . LYS A 1 14  ? 34.045  -35.346 12.536  1    37.505 ? 1022 LYS A HB2    1 c 
ATOM   200  H HB3    . LYS A 1 14  ? 34.123  -34.254 11.139  1    37.581 ? 1022 LYS A HB3    1 c 
ATOM   201  H HG2    . LYS A 1 14  ? 35.736  -32.825 12.489  1    47.325 ? 1022 LYS A HG2    1 c 
ATOM   202  H HG3    . LYS A 1 14  ? 35.757  -34.084 13.699  1    47.325 ? 1022 LYS A HG3    1 c 
ATOM   203  H HD2    . LYS A 1 14  ? 36.994  -35.573 12.288  1    55.549 ? 1022 LYS A HD2    1 c 
ATOM   204  H HD3    . LYS A 1 14  ? 36.721  -34.544 10.854  1    55.549 ? 1022 LYS A HD3    1 c 
ATOM   205  H HE2    . LYS A 1 14  ? 38.045  -32.789 11.737  1    63.29  ? 1022 LYS A HE2    1 c 
ATOM   206  H HE3    . LYS A 1 14  ? 38.038  -33.488 13.363  1    63.291 ? 1022 LYS A HE3    1 c 
ATOM   207  H HZ1    . LYS A 1 14  ? 40.096  -33.889 12.331  1    70.286 ? 1022 LYS A HZ1    1 ? 
ATOM   208  H HZ2    . LYS A 1 14  ? 39.301  -35.346 12.456  1    70.187 ? 1022 LYS A HZ2    1 ? 
ATOM   209  H HZ3    . LYS A 1 14  ? 39.391  -34.572 10.992  1    68.135 ? 1022 LYS A HZ3    1 ? 
ATOM   210  N N      . GLU A 1 15  ? 30.829  -33.941 12.988  1    21.402 ? 1023 GLU A N      1 ? 
ATOM   211  C CA     . GLU A 1 15  ? 29.464  -34.109 12.499  1    25.623 ? 1023 GLU A CA     1 ? 
ATOM   212  C C      . GLU A 1 15  ? 28.511  -33.515 13.542  1    19.873 ? 1023 GLU A C      1 ? 
ATOM   213  O O      . GLU A 1 15  ? 28.818  -33.555 14.738  1    19.09  ? 1023 GLU A O      1 ? 
ATOM   214  C CB     . GLU A 1 15  ? 29.149  -35.601 12.31   1    26.168 ? 1023 GLU A CB     1 ? 
ATOM   215  C CG     . GLU A 1 15  ? 29.743  -36.241 11.051  1    36.929 ? 1023 GLU A CG     1 ? 
ATOM   216  C CD     . GLU A 1 15  ? 29.041  -35.877 9.73    1    47.439 ? 1023 GLU A CD     1 ? 
ATOM   217  O OE1    . GLU A 1 15  ? 27.91   -36.368 9.461   1    48.41  ? 1023 GLU A OE1    1 ? 
ATOM   218  O OE2    . GLU A 1 15  ? 29.628  -35.075 8.958   1    51.905 ? 1023 GLU A OE2    1 ? 
ATOM   219  H H      . GLU A 1 15  ? 31.011  -34.273 13.948  1    21.76  ? 1023 GLU A H      1 ? 
ATOM   220  H HA     . GLU A 1 15  ? 29.356  -33.573 11.554  1    23.74  ? 1023 GLU A HA     1 c 
ATOM   221  H HB2    . GLU A 1 15  ? 29.519  -36.147 13.181  1    28.1   ? 1023 GLU A HB2    1 c 
ATOM   222  H HB3    . GLU A 1 15  ? 28.065  -35.726 12.28   1    28.1   ? 1023 GLU A HB3    1 c 
ATOM   223  H HG2    . GLU A 1 15  ? 30.793  -35.949 10.971  1    36.166 ? 1023 GLU A HG2    1 c 
ATOM   224  H HG3    . GLU A 1 15  ? 29.718  -37.327 11.163  1    36.166 ? 1023 GLU A HG3    1 c 
ATOM   225  N N      . PRO A 1 16  ? 27.357  -32.935 13.139  1    21.273 ? 1024 PRO A N      1 ? 
ATOM   226  C CA     . PRO A 1 16  ? 26.408  -32.366 14.087  1    19.674 ? 1024 PRO A CA     1 ? 
ATOM   227  C C      . PRO A 1 16  ? 25.759  -33.48  14.906  1    18.224 ? 1024 PRO A C      1 ? 
ATOM   228  O O      . PRO A 1 16  ? 25.505  -34.573 14.404  1    20.372 ? 1024 PRO A O      1 ? 
ATOM   229  C CB     . PRO A 1 16  ? 25.37   -31.669 13.206  1    19.772 ? 1024 PRO A CB     1 ? 
ATOM   230  C CG     . PRO A 1 16  ? 25.418  -32.508 11.941  1    20.162 ? 1024 PRO A CG     1 ? 
ATOM   231  C CD     . PRO A 1 16  ? 26.888  -32.805 11.751  1    21.447 ? 1024 PRO A CD     1 ? 
ATOM   232  H HA     . PRO A 1 16  ? 26.911  -31.651 14.738  1    19.706 ? 1024 PRO A HA     1 c 
ATOM   233  H HB2    . PRO A 1 16  ? 24.379  -31.698 13.663  1    19.835 ? 1024 PRO A HB2    1 c 
ATOM   234  H HB3    . PRO A 1 16  ? 25.653  -30.634 13.005  1    19.835 ? 1024 PRO A HB3    1 c 
ATOM   235  H HG2    . PRO A 1 16  ? 24.848  -33.431 12.061  1    20.439 ? 1024 PRO A HG2    1 c 
ATOM   236  H HG3    . PRO A 1 16  ? 25.022  -31.955 11.087  1    20.315 ? 1024 PRO A HG3    1 c 
ATOM   237  H HD2    . PRO A 1 16  ? 27.041  -33.734 11.198  1    21.147 ? 1024 PRO A HD2    1 c 
ATOM   238  H HD3    . PRO A 1 16  ? 27.4    -31.987 11.241  1    21.131 ? 1024 PRO A HD3    1 c 
ATOM   239  N N      . PRO A 1 17  ? 25.474  -33.233 16.186  1    17.676 ? 1025 PRO A N      1 ? 
ATOM   240  C CA     . PRO A 1 17  ? 24.703  -34.186 16.956  1    19.042 ? 1025 PRO A CA     1 ? 
ATOM   241  C C      . PRO A 1 17  ? 23.294  -34.299 16.398  1    16.205 ? 1025 PRO A C      1 ? 
ATOM   242  O O      . PRO A 1 17  ? 22.709  -33.307 15.97   1    16.42  ? 1025 PRO A O      1 ? 
ATOM   243  C CB     . PRO A 1 17  ? 24.678  -33.58  18.366  1    19.371 ? 1025 PRO A CB     1 ? 
ATOM   244  C CG     . PRO A 1 17  ? 25.728  -32.507 18.373  1    20.684 ? 1025 PRO A CG     1 ? 
ATOM   245  C CD     . PRO A 1 17  ? 25.799  -32.01  16.963  1    19.188 ? 1025 PRO A CD     1 ? 
ATOM   246  H HA     . PRO A 1 17  ? 25.195  -35.161 16.955  1    18.304 ? 1025 PRO A HA     1 c 
ATOM   247  H HB2    . PRO A 1 17  ? 23.695  -33.158 18.586  1    19.556 ? 1025 PRO A HB2    1 c 
ATOM   248  H HB3    . PRO A 1 17  ? 24.9    -34.341 19.116  1    19.575 ? 1025 PRO A HB3    1 c 
ATOM   249  H HG2    . PRO A 1 17  ? 25.452  -31.697 19.052  1    20.063 ? 1025 PRO A HG2    1 c 
ATOM   250  H HG3    . PRO A 1 17  ? 26.689  -32.911 18.683  1    20.299 ? 1025 PRO A HG3    1 c 
ATOM   251  H HD2    . PRO A 1 17  ? 25.065  -31.222 16.778  1    19.155 ? 1025 PRO A HD2    1 c 
ATOM   252  H HD3    . PRO A 1 17  ? 26.797  -31.643 16.72   1    19.162 ? 1025 PRO A HD3    1 c 
ATOM   253  N N      . LEU A 1 18  ? 22.746  -35.516 16.413  1    16.685 ? 1026 LEU A N      1 ? 
ATOM   254  C CA     . LEU A 1 18  ? 21.384  -35.742 15.942  1    17.785 ? 1026 LEU A CA     1 ? 
ATOM   255  C C      . LEU A 1 18  ? 20.691  -36.758 16.833  1    16.628 ? 1026 LEU A C      1 ? 
ATOM   256  O O      . LEU A 1 18  ? 21.203  -37.862 17.026  1    18.442 ? 1026 LEU A O      1 ? 
ATOM   257  C CB     . LEU A 1 18  ? 21.362  -36.239 14.494  1    17.259 ? 1026 LEU A CB     1 ? 
ATOM   258  C CG     . LEU A 1 18  ? 21.75   -35.227 13.412  1    20.967 ? 1026 LEU A CG     1 ? 
ATOM   259  C CD1    . LEU A 1 18  ? 21.885  -35.959 12.08   1    21.157 ? 1026 LEU A CD1    1 ? 
ATOM   260  C CD2    . LEU A 1 18  ? 20.729  -34.125 13.306  1    20.084 ? 1026 LEU A CD2    1 ? 
ATOM   261  H H      . LEU A 1 18  ? 23.309  -36.315 16.735  1    16.954 ? 1026 LEU A H      1 ? 
ATOM   262  H HA     . LEU A 1 18  ? 20.839  -34.799 16.005  1    17.255 ? 1026 LEU A HA     1 c 
ATOM   263  H HB2    . LEU A 1 18  ? 22.037  -37.094 14.42   1    18.129 ? 1026 LEU A HB2    1 c 
ATOM   264  H HB3    . LEU A 1 18  ? 20.356  -36.603 14.277  1    18.129 ? 1026 LEU A HB3    1 c 
ATOM   265  H HG     . LEU A 1 18  ? 22.715  -34.789 13.673  1    20.105 ? 1026 LEU A HG     1 c 
ATOM   266  H HD11   . LEU A 1 18  ? 22.643  -36.74  12.167  1    21.197 ? 1026 LEU A HD11   1 c 
ATOM   267  H HD12   . LEU A 1 18  ? 20.928  -36.41  11.812  1    21.123 ? 1026 LEU A HD12   1 c 
ATOM   268  H HD13   . LEU A 1 18  ? 22.182  -35.251 11.303  1    21.105 ? 1026 LEU A HD13   1 c 
ATOM   269  H HD21   . LEU A 1 18  ? 20.671  -33.587 14.254  1    20.276 ? 1026 LEU A HD21   1 c 
ATOM   270  H HD22   . LEU A 1 18  ? 21.02   -33.433 12.513  1    20.298 ? 1026 LEU A HD22   1 c 
ATOM   271  H HD23   . LEU A 1 18  ? 19.752  -34.554 13.072  1    20.227 ? 1026 LEU A HD23   1 c 
ATOM   272  N N      . ASN A 1 19  ? 19.526  -36.39  17.361  1    15.212 ? 1027 ASN A N      1 ? 
ATOM   273  C CA     . ASN A 1 19  ? 18.655  -37.332 18.062  1    16.64  ? 1027 ASN A CA     1 ? 
ATOM   274  C C      . ASN A 1 19  ? 19.341  -37.937 19.285  1    15.333 ? 1027 ASN A C      1 ? 
ATOM   275  O O      . ASN A 1 19  ? 19.112  -39.089 19.642  1    15.534 ? 1027 ASN A O      1 ? 
ATOM   276  C CB     . ASN A 1 19  ? 18.174  -38.409 17.092  1    18.31  ? 1027 ASN A CB     1 ? 
ATOM   277  C CG     . ASN A 1 19  ? 17.223  -37.846 16.069  1    18.343 ? 1027 ASN A CG     1 ? 
ATOM   278  O OD1    . ASN A 1 19  ? 16.244  -37.17  16.403  1    18.824 ? 1027 ASN A OD1    1 ? 
ATOM   279  N ND2    . ASN A 1 19  ? 17.572  -38.013 14.807  1    24.887 ? 1027 ASN A ND2    1 ? 
ATOM   280  H H      . ASN A 1 19  ? 19.184  -35.443 17.136  1    15.916 ? 1027 ASN A H      1 ? 
ATOM   281  H HA     . ASN A 1 19  ? 17.774  -36.784 18.403  1    16.417 ? 1027 ASN A HA     1 c 
ATOM   282  H HB2    . ASN A 1 19  ? 19.031  -38.853 16.583  1    17.959 ? 1027 ASN A HB2    1 c 
ATOM   283  H HB3    . ASN A 1 19  ? 17.667  -39.198 17.653  1    17.929 ? 1027 ASN A HB3    1 c 
ATOM   284  H HD21   . ASN A 1 19  ? 16.987  -37.573 14.081  1    20.623 ? 1027 ASN A HD21   1 ? 
ATOM   285  H HD22   . ASN A 1 19  ? 18.439  -38.562 14.593  1    21.037 ? 1027 ASN A HD22   1 ? 
ATOM   286  N N      . THR A 1 20  ? 20.17   -37.13  19.938  1    14.956 ? 1028 THR A N      1 ? 
ATOM   287  C CA     . THR A 1 20  ? 20.852  -37.547 21.16   1    13.786 ? 1028 THR A CA     1 ? 
ATOM   288  C C      . THR A 1 20  ? 19.846  -38.007 22.205  1    14.126 ? 1028 THR A C      1 ? 
ATOM   289  O O      . THR A 1 20  ? 20.069  -39.006 22.894  1    12.543 ? 1028 THR A O      1 ? 
ATOM   290  C CB     . THR A 1 20  ? 21.649  -36.356 21.687  1    14.462 ? 1028 THR A CB     1 ? 
ATOM   291  O OG1    . THR A 1 20  ? 22.402  -35.827 20.587  1    14.241 ? 1028 THR A OG1    1 ? 
ATOM   292  C CG2    . THR A 1 20  ? 22.575  -36.741 22.816  1    14.299 ? 1028 THR A CG2    1 ? 
ATOM   293  H H      . THR A 1 20  ? 20.37   -36.192 19.541  1    15.713 ? 1028 THR A H      1 ? 
ATOM   294  H HA     . THR A 1 20  ? 21.536  -38.366 20.927  1    14.177 ? 1028 THR A HA     1 c 
ATOM   295  H HB     . THR A 1 20  ? 20.959  -35.591 22.049  1    14.289 ? 1028 THR A HB     1 c 
ATOM   296  H HG1    . THR A 1 20  ? 22.94   -35.048 20.779  1    14.512 ? 1028 THR A HG1    1 ? 
ATOM   297  H HG21   . THR A 1 20  ? 21.989  -37.114 23.658  1    14.341 ? 1028 THR A HG21   1 c 
ATOM   298  H HG22   . THR A 1 20  ? 23.26   -37.521 22.477  1    14.342 ? 1028 THR A HG22   1 c 
ATOM   299  H HG23   . THR A 1 20  ? 23.147  -35.867 23.132  1    14.334 ? 1028 THR A HG23   1 c 
ATOM   300  N N      . TYR A 1 21  ? 18.753  -37.261 22.348  1    13.975 ? 1029 TYR A N      1 ? 
ATOM   301  C CA     . TYR A 1 21  ? 17.637  -37.659 23.191  1    14.893 ? 1029 TYR A CA     1 ? 
ATOM   302  C C      . TYR A 1 21  ? 16.408  -37.825 22.316  1    16.348 ? 1029 TYR A C      1 ? 
ATOM   303  O O      . TYR A 1 21  ? 16.15   -37.016 21.41   1    17.547 ? 1029 TYR A O      1 ? 
ATOM   304  C CB     . TYR A 1 21  ? 17.377  -36.648 24.311  1    14.467 ? 1029 TYR A CB     1 ? 
ATOM   305  C CG     . TYR A 1 21  ? 18.465  -36.709 25.351  1    15.011 ? 1029 TYR A CG     1 ? 
ATOM   306  C CD1    . TYR A 1 21  ? 19.646  -35.999 25.18   1    16.369 ? 1029 TYR A CD1    1 ? 
ATOM   307  C CD2    . TYR A 1 21  ? 18.343  -37.528 26.46   1    14.626 ? 1029 TYR A CD2    1 ? 
ATOM   308  C CE1    . TYR A 1 21  ? 20.665  -36.072 26.104  1    16.439 ? 1029 TYR A CE1    1 ? 
ATOM   309  C CE2    . TYR A 1 21  ? 19.36   -37.614 27.396  1    15.727 ? 1029 TYR A CE2    1 ? 
ATOM   310  C CZ     . TYR A 1 21  ? 20.53   -36.882 27.217  1    16.919 ? 1029 TYR A CZ     1 ? 
ATOM   311  O OH     . TYR A 1 21  ? 21.557  -36.94  28.121  1    16.854 ? 1029 TYR A OH     1 ? 
ATOM   312  H H      . TYR A 1 21  ? 18.618  -36.484 21.686  1    13.687 ? 1029 TYR A H      1 ? 
ATOM   313  H HA     . TYR A 1 21  ? 17.873  -38.623 23.645  1    14.887 ? 1029 TYR A HA     1 c 
ATOM   314  H HB2    . TYR A 1 21  ? 17.338  -35.644 23.883  1    14.677 ? 1029 TYR A HB2    1 c 
ATOM   315  H HB3    . TYR A 1 21  ? 16.415  -36.873 24.778  1    14.677 ? 1029 TYR A HB3    1 c 
ATOM   316  H HD1    . TYR A 1 21  ? 19.765  -35.364 24.308  1    16.065 ? 1029 TYR A HD1    1 c 
ATOM   317  H HD2    . TYR A 1 21  ? 17.435  -38.105 26.604  1    14.986 ? 1029 TYR A HD2    1 c 
ATOM   318  H HE1    . TYR A 1 21  ? 21.573  -35.5   25.958  1    16.476 ? 1029 TYR A HE1    1 c 
ATOM   319  H HE2    . TYR A 1 21  ? 19.246  -38.248 28.269  1    15.731 ? 1029 TYR A HE2    1 c 
ATOM   320  H HH     . TYR A 1 21  ? 21.271  -37.589 28.773  1    17.714 ? 1029 TYR A HH     1 ? 
ATOM   321  N N      . LYS A 1 22  ? 15.668  -38.888 22.603  1    17.529 ? 1030 LYS A N      1 ? 
ATOM   322  C CA     . LYS A 1 22  ? 14.505  -39.268 21.829  1    19.169 ? 1030 LYS A CA     1 ? 
ATOM   323  C C      . LYS A 1 22  ? 13.25   -39.121 22.664  1    19.315 ? 1030 LYS A C      1 ? 
ATOM   324  O O      . LYS A 1 22  ? 13.314  -39.064 23.901  1    16.864 ? 1030 LYS A O      1 ? 
ATOM   325  C CB     . LYS A 1 22  ? 14.673  -40.732 21.402  1    21.169 ? 1030 LYS A CB     1 ? 
ATOM   326  C CG     . LYS A 1 22  ? 15.815  -40.952 20.406  1    23.361 ? 1030 LYS A CG     1 ? 
ATOM   327  C CD     . LYS A 1 22  ? 16.16   -42.436 20.335  1    30.218 ? 1030 LYS A CD     1 ? 
ATOM   328  C CE     . LYS A 1 22  ? 17.348  -42.83  19.471  1    35.13  ? 1030 LYS A CE     1 ? 
ATOM   329  N NZ     . LYS A 1 22  ? 17.55   -44.298 19.511  1    37.341 ? 1030 LYS A NZ     1 ? 
ATOM   330  H H      . LYS A 1 22  ? 16.038  -39.556 23.299  1    17.889 ? 1030 LYS A H      1 ? 
ATOM   331  H HA     . LYS A 1 22  ? 14.437  -38.625 20.951  1    19.196 ? 1030 LYS A HA     1 c 
ATOM   332  H HB2    . LYS A 1 22  ? 14.863  -41.339 22.289  1    21.278 ? 1030 LYS A HB2    1 c 
ATOM   333  H HB3    . LYS A 1 22  ? 13.742  -41.08  20.95   1    21.188 ? 1030 LYS A HB3    1 c 
ATOM   334  H HG2    . LYS A 1 22  ? 15.508  -40.597 19.42   1    24.174 ? 1030 LYS A HG2    1 c 
ATOM   335  H HG3    . LYS A 1 22  ? 16.69   -40.385 20.729  1    24.139 ? 1030 LYS A HG3    1 c 
ATOM   336  H HD2    . LYS A 1 22  ? 16.343  -42.787 21.352  1    29.609 ? 1030 LYS A HD2    1 c 
ATOM   337  H HD3    . LYS A 1 22  ? 15.279  -42.969 19.972  1    29.532 ? 1030 LYS A HD3    1 c 
ATOM   338  H HE2    . LYS A 1 22  ? 17.176  -42.518 18.44   1    34.597 ? 1030 LYS A HE2    1 c 
ATOM   339  H HE3    . LYS A 1 22  ? 18.246  -42.335 19.846  1    34.6   ? 1030 LYS A HE3    1 c 
ATOM   340  H HZ1    . LYS A 1 22  ? 17.523  -44.63  20.475  1    36.373 ? 1030 LYS A HZ1    1 ? 
ATOM   341  H HZ2    . LYS A 1 22  ? 16.822  -44.79  18.974  1    36.188 ? 1030 LYS A HZ2    1 ? 
ATOM   342  H HZ3    . LYS A 1 22  ? 18.462  -44.51  19.125  1    36.392 ? 1030 LYS A HZ3    1 ? 
ATOM   343  N N      . PRO A 1 23  ? 12.069  -39.053 22.026  1    21.977 ? 1031 PRO A N      1 ? 
ATOM   344  C CA     . PRO A 1 23  ? 10.855  -38.695 22.763  1    22.507 ? 1031 PRO A CA     1 ? 
ATOM   345  C C      . PRO A 1 23  ? 10.518  -39.615 23.928  1    25.197 ? 1031 PRO A C      1 ? 
ATOM   346  O O      . PRO A 1 23  ? 9.963   -39.151 24.932  1    22.75  ? 1031 PRO A O      1 ? 
ATOM   347  C CB     . PRO A 1 23  ? 9.762   -38.695 21.694  1    21.483 ? 1031 PRO A CB     1 ? 
ATOM   348  C CG     . PRO A 1 23  ? 10.525  -38.352 20.443  1    21.485 ? 1031 PRO A CG     1 ? 
ATOM   349  C CD     . PRO A 1 23  ? 11.826  -39.106 20.57   1    20.694 ? 1031 PRO A CD     1 ? 
ATOM   350  H HA     . PRO A 1 23  ? 10.966  -37.678 23.144  1    22.616 ? 1031 PRO A HA     1 c 
ATOM   351  H HB2    . PRO A 1 23  ? 9.292   -39.677 21.613  1    21.698 ? 1031 PRO A HB2    1 c 
ATOM   352  H HB3    . PRO A 1 23  ? 9.001   -37.943 21.91   1    21.698 ? 1031 PRO A HB3    1 c 
ATOM   353  H HG2    . PRO A 1 23  ? 9.98    -38.673 19.553  1    21.31  ? 1031 PRO A HG2    1 c 
ATOM   354  H HG3    . PRO A 1 23  ? 10.707  -37.278 20.379  1    21.31  ? 1031 PRO A HG3    1 c 
ATOM   355  H HD2    . PRO A 1 23  ? 11.728  -40.137 20.227  1    21.135 ? 1031 PRO A HD2    1 c 
ATOM   356  H HD3    . PRO A 1 23  ? 12.628  -38.612 20.02   1    21.112 ? 1031 PRO A HD3    1 c 
ATOM   357  N N      . LYS A 1 24  ? 10.827  -40.91  23.835  1    27.697 ? 1032 LYS A N      1 ? 
ATOM   358  C CA     . LYS A 1 24  ? 10.463  -41.82  24.906  1    26.531 ? 1032 LYS A CA     1 ? 
ATOM   359  C C      . LYS A 1 24  ? 11.325  -41.623 26.161  1    27.956 ? 1032 LYS A C      1 ? 
ATOM   360  O O      . LYS A 1 24  ? 10.9    -42.003 27.259  1    25.543 ? 1032 LYS A O      1 ? 
ATOM   361  C CB     . LYS A 1 24  ? 10.607  -43.283 24.465  1    33.301 ? 1032 LYS A CB     1 ? 
ATOM   362  C CG     . LYS A 1 24  ? 12.055  -43.68  23.986  1    46.979 ? 1032 LYS A CG     1 ? 
ATOM   363  C CD     . LYS A 1 24  ? 12.267  -45.029 23.269  1    46.522 ? 1032 LYS A CD     1 ? 
ATOM   364  C CE     . LYS A 1 24  ? 13.186  -45.056 22.058  1    39.042 ? 1032 LYS A CE     1 ? 
ATOM   365  N NZ     . LYS A 1 24  ? 14.296  -44.156 22.298  1    38.653 ? 1032 LYS A NZ     1 ? 
ATOM   366  H H      . LYS A 1 24  ? 11.238  -41.268 22.956  1    22.18  ? 1032 LYS A H      1 ? 
ATOM   367  H HA     . LYS A 1 24  ? 9.419   -41.637 25.17   1    28.068 ? 1032 LYS A HA     1 c 
ATOM   368  H HB2    . LYS A 1 24  ? 10.328  -43.931 25.299  1    34.115 ? 1032 LYS A HB2    1 c 
ATOM   369  H HB3    . LYS A 1 24  ? 9.909   -43.473 23.648  1    34.115 ? 1032 LYS A HB3    1 c 
ATOM   370  H HG2    . LYS A 1 24  ? 12.42   -42.885 23.337  1    43.046 ? 1032 LYS A HG2    1 c 
ATOM   371  H HG3    . LYS A 1 24  ? 12.701  -43.671 24.865  1    43.246 ? 1032 LYS A HG3    1 c 
ATOM   372  H HD2    . LYS A 1 24  ? 12.647  -45.742 24.004  1    44.854 ? 1032 LYS A HD2    1 c 
ATOM   373  H HD3    . LYS A 1 24  ? 11.285  -45.397 22.96   1    44.853 ? 1032 LYS A HD3    1 c 
ATOM   374  H HE2    . LYS A 1 24  ? 13.57   -46.067 21.908  1    40.448 ? 1032 LYS A HE2    1 c 
ATOM   375  H HE3    . LYS A 1 24  ? 12.651  -44.752 21.156  1    40.44  ? 1032 LYS A HE3    1 c 
ATOM   376  H HZ1    . LYS A 1 24  ? 15.168  -44.506 21.897  1    36.831 ? 1032 LYS A HZ1    1 ? 
ATOM   377  H HZ2    . LYS A 1 24  ? 14.087  -43.227 21.926  1    36.835 ? 1032 LYS A HZ2    1 ? 
ATOM   378  H HZ3    . LYS A 1 24  ? 14.439  -44.11  23.303  1    41.003 ? 1032 LYS A HZ3    1 ? 
ATOM   379  N N      . GLU A 1 25  ? 12.516  -41.037 26.014  1    23.776 ? 1033 GLU A N      1 ? 
ATOM   380  C CA     . GLU A 1 25  ? 13.396  -40.761 27.148  1    24.057 ? 1033 GLU A CA     1 ? 
ATOM   381  C C      . GLU A 1 25  ? 14.046  -39.4   26.943  1    17.925 ? 1033 GLU A C      1 ? 
ATOM   382  O O      . GLU A 1 25  ? 15.234  -39.295 26.62   1    16.905 ? 1033 GLU A O      1 ? 
ATOM   383  C CB     . GLU A 1 25  ? 14.453  -41.848 27.313  1    28.277 ? 1033 GLU A CB     1 ? 
ATOM   384  C CG     . GLU A 1 25  ? 13.904  -43.271 27.462  1    35.373 ? 1033 GLU A CG     1 ? 
ATOM   385  C CD     . GLU A 1 25  ? 14.953  -44.341 27.137  1    44.556 ? 1033 GLU A CD     1 ? 
ATOM   386  O OE1    . GLU A 1 25  ? 15.602  -44.264 26.058  1    44.332 ? 1033 GLU A OE1    1 ? 
ATOM   387  O OE2    . GLU A 1 25  ? 15.14   -45.25  27.982  1    44.347 ? 1033 GLU A OE2    1 ? 
ATOM   388  H H      . GLU A 1 25  ? 12.753  -40.633 25.091  1    23.557 ? 1033 GLU A H      1 ? 
ATOM   389  H HA     . GLU A 1 25  ? 12.79   -40.723 28.054  1    23.395 ? 1033 GLU A HA     1 c 
ATOM   390  H HB2    . GLU A 1 25  ? 15.109  -41.832 26.443  1    28.547 ? 1033 GLU A HB2    1 c 
ATOM   391  H HB3    . GLU A 1 25  ? 15.061  -41.615 28.19   1    28.637 ? 1033 GLU A HB3    1 c 
ATOM   392  H HG2    . GLU A 1 25  ? 13.559  -43.418 28.488  1    35.411 ? 1033 GLU A HG2    1 c 
ATOM   393  H HG3    . GLU A 1 25  ? 13.051  -43.404 26.798  1    35.313 ? 1033 GLU A HG3    1 c 
ATOM   394  N N      . PRO A 1 26  ? 13.286  -38.321 27.122  1    15.839 ? 1034 PRO A N      1 ? 
ATOM   395  C CA     . PRO A 1 26  ? 13.834  -36.993 26.921  1    15.573 ? 1034 PRO A CA     1 ? 
ATOM   396  C C      . PRO A 1 26  ? 14.874  -36.646 27.973  1    15.709 ? 1034 PRO A C      1 ? 
ATOM   397  O O      . PRO A 1 26  ? 15.011  -37.316 28.997  1    14.232 ? 1034 PRO A O      1 ? 
ATOM   398  C CB     . PRO A 1 26  ? 12.633  -36.068 27.008  1    15.798 ? 1034 PRO A CB     1 ? 
ATOM   399  C CG     . PRO A 1 26  ? 11.427  -36.974 26.926  1    17.765 ? 1034 PRO A CG     1 ? 
ATOM   400  C CD     . PRO A 1 26  ? 11.864  -38.28  27.484  1    15.616 ? 1034 PRO A CD     1 ? 
ATOM   401  H HA     . PRO A 1 26  ? 14.282  -36.928 25.927  1    15.686 ? 1034 PRO A HA     1 c 
ATOM   402  H HB2    . PRO A 1 26  ? 12.638  -35.515 27.95   1    16.153 ? 1034 PRO A HB2    1 c 
ATOM   403  H HB3    . PRO A 1 26  ? 12.635  -35.352 26.184  1    16.156 ? 1034 PRO A HB3    1 c 
ATOM   404  H HG2    . PRO A 1 26  ? 10.597  -36.568 27.507  1    16.916 ? 1034 PRO A HG2    1 c 
ATOM   405  H HG3    . PRO A 1 26  ? 11.104  -37.092 25.89   1    16.896 ? 1034 PRO A HG3    1 c 
ATOM   406  H HD2    . PRO A 1 26  ? 11.738  -38.313 28.569  1    16.142 ? 1034 PRO A HD2    1 c 
ATOM   407  H HD3    . PRO A 1 26  ? 11.319  -39.107 27.032  1    16.268 ? 1034 PRO A HD3    1 c 
ATOM   408  N N      . PHE A 1 27  ? 15.601  -35.56  27.715  1    14.328 ? 1035 PHE A N      1 ? 
ATOM   409  C CA     . PHE A 1 27  ? 16.459  -34.993 28.732  1    14.905 ? 1035 PHE A CA     1 ? 
ATOM   410  C C      . PHE A 1 27  ? 15.651  -33.979 29.54   1    14.108 ? 1035 PHE A C      1 ? 
ATOM   411  O O      . PHE A 1 27  ? 15.021  -33.095 28.966  1    13.945 ? 1035 PHE A O      1 ? 
ATOM   412  C CB     . PHE A 1 27  ? 17.668  -34.289 28.106  1    14.445 ? 1035 PHE A CB     1 ? 
ATOM   413  C CG     . PHE A 1 27  ? 18.564  -33.687 29.153  1    13.705 ? 1035 PHE A CG     1 ? 
ATOM   414  C CD1    . PHE A 1 27  ? 19.417  -34.503 29.874  1    15.405 ? 1035 PHE A CD1    1 ? 
ATOM   415  C CD2    . PHE A 1 27  ? 18.489  -32.335 29.469  1    15.316 ? 1035 PHE A CD2    1 ? 
ATOM   416  C CE1    . PHE A 1 27  ? 20.216  -33.975 30.884  1    16.219 ? 1035 PHE A CE1    1 ? 
ATOM   417  C CE2    . PHE A 1 27  ? 19.281  -31.802 30.492  1    14.731 ? 1035 PHE A CE2    1 ? 
ATOM   418  C CZ     . PHE A 1 27  ? 20.143  -32.63  31.202  1    14.979 ? 1035 PHE A CZ     1 ? 
ATOM   419  H H      . PHE A 1 27  ? 15.476  -35.031 26.837  1    14.437 ? 1035 PHE A H      1 ? 
ATOM   420  H HA     . PHE A 1 27  ? 16.809  -35.787 29.394  1    14.569 ? 1035 PHE A HA     1 c 
ATOM   421  H HB2    . PHE A 1 27  ? 18.236  -35.014 27.52   1    14.38  ? 1035 PHE A HB2    1 c 
ATOM   422  H HB3    . PHE A 1 27  ? 17.313  -33.501 27.439  1    14.377 ? 1035 PHE A HB3    1 c 
ATOM   423  H HD1    . PHE A 1 27  ? 19.468  -35.562 29.644  1    15.18  ? 1035 PHE A HD1    1 c 
ATOM   424  H HD2    . PHE A 1 27  ? 17.801  -31.693 28.928  1    14.832 ? 1035 PHE A HD2    1 c 
ATOM   425  H HE1    . PHE A 1 27  ? 20.892  -34.624 31.431  1    15.732 ? 1035 PHE A HE1    1 c 
ATOM   426  H HE2    . PHE A 1 27  ? 19.23   -30.744 30.723  1    14.898 ? 1035 PHE A HE2    1 c 
ATOM   427  H HZ     . PHE A 1 27  ? 20.781  -32.219 31.976  1    15.183 ? 1035 PHE A HZ     1 c 
ATOM   428  N N      . THR A 1 28  ? 15.674  -34.094 30.868  1    14.196 ? 1036 THR A N      1 ? 
ATOM   429  C CA     . THR A 1 28  ? 14.969  -33.141 31.714  1    15.474 ? 1036 THR A CA     1 ? 
ATOM   430  C C      . THR A 1 28  ? 15.875  -31.943 31.979  1    14.739 ? 1036 THR A C      1 ? 
ATOM   431  O O      . THR A 1 28  ? 16.75   -31.992 32.841  1    15.95  ? 1036 THR A O      1 ? 
ATOM   432  C CB     . THR A 1 28  ? 14.459  -33.769 33.003  1    15.645 ? 1036 THR A CB     1 ? 
ATOM   433  O OG1    . THR A 1 28  ? 13.482  -34.749 32.62   1    16.207 ? 1036 THR A OG1    1 ? 
ATOM   434  C CG2    . THR A 1 28  ? 13.685  -32.748 33.829  1    16.255 ? 1036 THR A CG2    1 ? 
ATOM   435  H H      . THR A 1 28  ? 16.23   -34.851 31.284  1    13.868 ? 1036 THR A H      1 ? 
ATOM   436  H HA     . THR A 1 28  ? 14.1    -32.787 31.157  1    15.106 ? 1036 THR A HA     1 c 
ATOM   437  H HB     . THR A 1 28  ? 15.264  -34.232 33.578  1    15.824 ? 1036 THR A HB     1 c 
ATOM   438  H HG1    . THR A 1 28  ? 13.885  -35.498 32.142  1    16.274 ? 1036 THR A HG1    1 ? 
ATOM   439  H HG21   . THR A 1 28  ? 13.255  -33.239 34.704  1    16.077 ? 1036 THR A HG21   1 c 
ATOM   440  H HG22   . THR A 1 28  ? 14.357  -31.952 34.154  1    16.071 ? 1036 THR A HG22   1 c 
ATOM   441  H HG23   . THR A 1 28  ? 12.883  -32.322 33.223  1    16.063 ? 1036 THR A HG23   1 c 
ATOM   442  N N      . ALA A 1 29  ? 15.642  -30.881 31.216  1    14.846 ? 1037 ALA A N      1 ? 
ATOM   443  C CA     . ALA A 1 29  ? 16.388  -29.636 31.312  1    13.841 ? 1037 ALA A CA     1 ? 
ATOM   444  C C      . ALA A 1 29  ? 15.678  -28.691 32.288  1    13.27  ? 1037 ALA A C      1 ? 
ATOM   445  O O      . ALA A 1 29  ? 14.552  -28.936 32.725  1    12.527 ? 1037 ALA A O      1 ? 
ATOM   446  C CB     . ALA A 1 29  ? 16.512  -28.995 29.937  1    14.04  ? 1037 ALA A CB     1 ? 
ATOM   447  H H      . ALA A 1 29  ? 14.836  -30.915 30.566  1    14.276 ? 1037 ALA A H      1 ? 
ATOM   448  H HA     . ALA A 1 29  ? 17.384  -29.855 31.703  1    13.967 ? 1037 ALA A HA     1 c 
ATOM   449  H HB1    . ALA A 1 29  ? 17.055  -28.052 30.019  1    13.985 ? 1037 ALA A HB1    1 c 
ATOM   450  H HB2    . ALA A 1 29  ? 17.052  -29.666 29.266  1    13.989 ? 1037 ALA A HB2    1 c 
ATOM   451  H HB3    . ALA A 1 29  ? 15.517  -28.803 29.53   1    14.008 ? 1037 ALA A HB3    1 c 
ATOM   452  N N      . THR A 1 30  ? 16.359  -27.594 32.629  1    13.968 ? 1038 THR A N      1 ? 
ATOM   453  C CA     . THR A 1 30  ? 15.841  -26.637 33.592  1    13.482 ? 1038 THR A CA     1 ? 
ATOM   454  C C      . THR A 1 30  ? 15.838  -25.236 33.003  1    13.477 ? 1038 THR A C      1 ? 
ATOM   455  O O      . THR A 1 30  ? 16.83   -24.793 32.424  1    15.606 ? 1038 THR A O      1 ? 
ATOM   456  C CB     . THR A 1 30  ? 16.672  -26.673 34.874  1    14.442 ? 1038 THR A CB     1 ? 
ATOM   457  O OG1    . THR A 1 30  ? 16.667  -28.016 35.383  1    14.561 ? 1038 THR A OG1    1 ? 
ATOM   458  C CG2    . THR A 1 30  ? 16.108  -25.716 35.911  1    14.129 ? 1038 THR A CG2    1 ? 
ATOM   459  H H      . THR A 1 30  ? 17.339  -27.465 32.31   1    13.726 ? 1038 THR A H      1 ? 
ATOM   460  H HA     . THR A 1 30  ? 14.815  -26.915 33.838  1    13.732 ? 1038 THR A HA     1 c 
ATOM   461  H HB     . THR A 1 30  ? 17.698  -26.38  34.647  1    14.236 ? 1038 THR A HB     1 c 
ATOM   462  H HG1    . THR A 1 30  ? 17.14   -28.126 36.216  1    16.564 ? 1038 THR A HG1    1 ? 
ATOM   463  H HG21   . THR A 1 30  ? 15.066  -25.975 36.115  1    14.242 ? 1038 THR A HG21   1 c 
ATOM   464  H HG22   . THR A 1 30  ? 16.685  -25.794 36.832  1    14.243 ? 1038 THR A HG22   1 c 
ATOM   465  H HG23   . THR A 1 30  ? 16.158  -24.694 35.534  1    14.322 ? 1038 THR A HG23   1 c 
ATOM   466  N N      . ILE A 1 31  ? 14.719  -24.53  33.156  1    12.304 ? 1039 ILE A N      1 ? 
ATOM   467  C CA     . ILE A 1 31  ? 14.621  -23.16  32.687  1    12.384 ? 1039 ILE A CA     1 ? 
ATOM   468  C C      . ILE A 1 31  ? 15.535  -22.256 33.495  1    14.223 ? 1039 ILE A C      1 ? 
ATOM   469  O O      . ILE A 1 31  ? 15.509  -22.265 34.735  1    12.596 ? 1039 ILE A O      1 ? 
ATOM   470  C CB     . ILE A 1 31  ? 13.162  -22.687 32.779  1    12.77  ? 1039 ILE A CB     1 ? 
ATOM   471  C CG1    . ILE A 1 31  ? 12.266  -23.49  31.84   1    13.148 ? 1039 ILE A CG1    1 ? 
ATOM   472  C CG2    . ILE A 1 31  ? 13.055  -21.173 32.551  1    12.609 ? 1039 ILE A CG2    1 ? 
ATOM   473  C CD1    . ILE A 1 31  ? 12.338  -23.02  30.397  1    14.406 ? 1039 ILE A CD1    1 ? 
ATOM   474  H H      . ILE A 1 31  ? 13.906  -24.918 33.679  1    11.821 ? 1039 ILE A H      1 ? 
ATOM   475  H HA     . ILE A 1 31  ? 14.931  -23.128 31.641  1    12.747 ? 1039 ILE A HA     1 c 
ATOM   476  H HB     . ILE A 1 31  ? 12.822  -22.887 33.797  1    12.738 ? 1039 ILE A HB     1 c 
ATOM   477  H HG12   . ILE A 1 31  ? 12.558  -24.542 31.885  1    13.321 ? 1039 ILE A HG12   1 c 
ATOM   478  H HG13   . ILE A 1 31  ? 11.234  -23.413 32.186  1    13.319 ? 1039 ILE A HG13   1 c 
ATOM   479  H HG21   . ILE A 1 31  ? 12.003  -20.891 32.464  1    12.655 ? 1039 ILE A HG21   1 c 
ATOM   480  H HG22   . ILE A 1 31  ? 13.502  -20.64  33.392  1    12.662 ? 1039 ILE A HG22   1 c 
ATOM   481  H HG23   . ILE A 1 31  ? 13.577  -20.902 31.631  1    12.656 ? 1039 ILE A HG23   1 c 
ATOM   482  H HD11   . ILE A 1 31  ? 11.947  -22.004 30.318  1    14.031 ? 1039 ILE A HD11   1 c 
ATOM   483  H HD12   . ILE A 1 31  ? 13.376  -23.036 30.058  1    14.037 ? 1039 ILE A HD12   1 c 
ATOM   484  H HD13   . ILE A 1 31  ? 11.742  -23.685 29.769  1    14.019 ? 1039 ILE A HD13   1 c 
ATOM   485  N N      . VAL A 1 32  ? 16.3    -21.431 32.784  1    13.757 ? 1040 VAL A N      1 ? 
ATOM   486  C CA     . VAL A 1 32  ? 17.107  -20.379 33.393  1    13.26  ? 1040 VAL A CA     1 ? 
ATOM   487  C C      . VAL A 1 32  ? 16.329  -19.071 33.449  1    14.587 ? 1040 VAL A C      1 ? 
ATOM   488  O O      . VAL A 1 32  ? 16.285  -18.413 34.492  1    15.039 ? 1040 VAL A O      1 ? 
ATOM   489  C CB     . VAL A 1 32  ? 18.431  -20.194 32.627  1    14.567 ? 1040 VAL A CB     1 ? 
ATOM   490  C CG1    . VAL A 1 32  ? 19.215  -19.015 33.193  1    14.43  ? 1040 VAL A CG1    1 ? 
ATOM   491  C CG2    . VAL A 1 32  ? 19.244  -21.476 32.641  1    15.07  ? 1040 VAL A CG2    1 ? 
ATOM   492  H H      . VAL A 1 32  ? 16.256  -21.453 31.747  1    12.782 ? 1040 VAL A H      1 ? 
ATOM   493  H HA     . VAL A 1 32  ? 17.344  -20.679 34.415  1    13.854 ? 1040 VAL A HA     1 c 
ATOM   494  H HB     . VAL A 1 32  ? 18.176  -19.966 31.59   1    14.387 ? 1040 VAL A HB     1 c 
ATOM   495  H HG11   . VAL A 1 32  ? 18.68   -18.086 32.989  1    14.486 ? 1040 VAL A HG11   1 c 
ATOM   496  H HG12   . VAL A 1 32  ? 19.334  -19.139 34.271  1    14.486 ? 1040 VAL A HG12   1 c 
ATOM   497  H HG13   . VAL A 1 32  ? 20.2    -18.974 32.721  1    14.542 ? 1040 VAL A HG13   1 c 
ATOM   498  H HG21   . VAL A 1 32  ? 18.68   -22.273 32.153  1    14.909 ? 1040 VAL A HG21   1 c 
ATOM   499  H HG22   . VAL A 1 32  ? 20.184  -21.318 32.108  1    14.914 ? 1040 VAL A HG22   1 c 
ATOM   500  H HG23   . VAL A 1 32  ? 19.457  -21.761 33.674  1    14.877 ? 1040 VAL A HG23   1 c 
ATOM   501  N N      . SER A 1 33  ? 15.712  -18.684 32.332  1    14.219 ? 1041 SER A N      1 ? 
ATOM   502  C CA     . SER A 1 33  ? 15.016  -17.405 32.276  1    14.384 ? 1041 SER A CA     1 ? 
ATOM   503  C C      . SER A 1 33  ? 14.026  -17.437 31.113  1    14.306 ? 1041 SER A C      1 ? 
ATOM   504  O O      . SER A 1 33  ? 14.194  -18.178 30.14   1    13.246 ? 1041 SER A O      1 ? 
ATOM   505  C CB     . SER A 1 33  ? 15.984  -16.244 32.079  1    14.499 ? 1041 SER A CB     1 ? 
ATOM   506  O OG     . SER A 1 33  ? 16.723  -16.398 30.872  1    14.683 ? 1041 SER A OG     1 ? 
ATOM   507  H H      . SER A 1 33  ? 15.732  -19.275 31.48   1    14.048 ? 1041 SER A H      1 ? 
ATOM   508  H HA     . SER A 1 33  ? 14.464  -17.259 33.207  1    14.363 ? 1041 SER A HA     1 c 
ATOM   509  H HB2    . SER A 1 33  ? 15.423  -15.307 32.045  1    14.517 ? 1041 SER A HB2    1 c 
ATOM   510  H HB3    . SER A 1 33  ? 16.673  -16.2   32.925  1    14.517 ? 1041 SER A HB3    1 c 
ATOM   511  H HG     . SER A 1 33  ? 16.187  -16.09  30.11   1    15.335 ? 1041 SER A HG     1 ? 
ATOM   512  N N      . VAL A 1 34  ? 13.001  -16.599 31.234  1    13.882 ? 1042 VAL A N      1 ? 
ATOM   513  C CA     . VAL A 1 34  ? 12.028  -16.332 30.195  1    14.668 ? 1042 VAL A CA     1 ? 
ATOM   514  C C      . VAL A 1 34  ? 11.771  -14.835 30.199  1    13.978 ? 1042 VAL A C      1 ? 
ATOM   515  O O      . VAL A 1 34  ? 11.481  -14.268 31.258  1    13.412 ? 1042 VAL A O      1 ? 
ATOM   516  C CB     . VAL A 1 34  ? 10.697  -17.073 30.424  1    14.592 ? 1042 VAL A CB     1 ? 
ATOM   517  C CG1    . VAL A 1 34  ? 9.665   -16.665 29.386  1    15.838 ? 1042 VAL A CG1    1 ? 
ATOM   518  C CG2    . VAL A 1 34  ? 10.901  -18.573 30.378  1    15.754 ? 1042 VAL A CG2    1 ? 
ATOM   519  H H      . VAL A 1 34  ? 12.922  -16.05  32.114  1    13.141 ? 1042 VAL A H      1 ? 
ATOM   520  H HA     . VAL A 1 34  ? 12.443  -16.626 29.231  1    14.365 ? 1042 VAL A HA     1 c 
ATOM   521  H HB     . VAL A 1 34  ? 10.329  -16.796 31.414  1    15.028 ? 1042 VAL A HB     1 c 
ATOM   522  H HG11   . VAL A 1 34  ? 8.776   -17.291 29.492  1    15.473 ? 1042 VAL A HG11   1 c 
ATOM   523  H HG12   . VAL A 1 34  ? 9.39    -15.619 29.53   1    15.466 ? 1042 VAL A HG12   1 c 
ATOM   524  H HG13   . VAL A 1 34  ? 10.083  -16.798 28.385  1    15.455 ? 1042 VAL A HG13   1 c 
ATOM   525  H HG21   . VAL A 1 34  ? 9.944   -19.077 30.53   1    15.392 ? 1042 VAL A HG21   1 c 
ATOM   526  H HG22   . VAL A 1 34  ? 11.31   -18.856 29.406  1    15.429 ? 1042 VAL A HG22   1 c 
ATOM   527  H HG23   . VAL A 1 34  ? 11.597  -18.871 31.165  1    15.392 ? 1042 VAL A HG23   1 c 
ATOM   528  N N      . GLU A 1 35  ? 11.86   -14.189 29.037  1    13.792 ? 1043 GLU A N      1 ? 
ATOM   529  C CA     . GLU A 1 35  ? 11.577  -12.768 28.939  1    13.52  ? 1043 GLU A CA     1 ? 
ATOM   530  C C      . GLU A 1 35  ? 10.852  -12.485 27.628  1    16.446 ? 1043 GLU A C      1 ? 
ATOM   531  O O      . GLU A 1 35  ? 11.139  -13.086 26.594  1    16.216 ? 1043 GLU A O      1 ? 
ATOM   532  C CB     . GLU A 1 35  ? 12.917  -12.062 28.971  1    15.108 ? 1043 GLU A CB     1 ? 
ATOM   533  H H      . GLU A 1 35  ? 12.127  -14.707 28.181  1    13.704 ? 1043 GLU A H      1 ? 
ATOM   534  H HA     . GLU A 1 35  ? 10.952  -12.463 29.781  1    14.318 ? 1043 GLU A HA     1 c 
ATOM   535  N N      . SER A 1 36  ? 9.928   -11.529 27.672  1    18.558 ? 1044 SER A N      1 ? 
ATOM   536  C CA     . SER A 1 36  ? 9.334   -11.034 26.446  1    15.234 ? 1044 SER A CA     1 ? 
ATOM   537  C C      . SER A 1 36  ? 10.377  -10.261 25.647  1    14.955 ? 1044 SER A C      1 ? 
ATOM   538  O O      . SER A 1 36  ? 11.157  -9.486  26.206  1    13.967 ? 1044 SER A O      1 ? 
ATOM   539  C CB     . SER A 1 36  ? 8.169   -10.112 26.759  1    15.427 ? 1044 SER A CB     1 ? 
ATOM   540  O OG     . SER A 1 36  ? 7.727   -9.513  25.548  1    16.05  ? 1044 SER A OG     1 ? 
ATOM   541  H H      . SER A 1 36  ? 9.747   -10.999 28.552  1    17.03  ? 1044 SER A H      1 ? 
ATOM   542  H HA     . SER A 1 36  ? 8.979   -11.879 25.853  1    15.77  ? 1044 SER A HA     1 c 
ATOM   543  H HB2    . SER A 1 36  ? 7.356   -10.684 27.209  1    15.527 ? 1044 SER A HB2    1 c 
ATOM   544  H HB3    . SER A 1 36  ? 8.489   -9.338  27.461  1    15.527 ? 1044 SER A HB3    1 c 
ATOM   545  H HG     . SER A 1 36  ? 6.813   -9.823  25.413  1    15.955 ? 1044 SER A HG     1 ? 
ATOM   546  N N      . LEU A 1 37  ? 10.363  -10.459 24.335  1    13.485 ? 1045 LEU A N      1 ? 
ATOM   547  C CA     . LEU A 1 37  ? 11.239  -9.751  23.417  1    14.902 ? 1045 LEU A CA     1 ? 
ATOM   548  C C      . LEU A 1 37  ? 10.583  -8.516  22.807  1    17.841 ? 1045 LEU A C      1 ? 
ATOM   549  O O      . LEU A 1 37  ? 11.23   -7.82   22.012  1    18.439 ? 1045 LEU A O      1 ? 
ATOM   550  C CB     . LEU A 1 37  ? 11.672  -10.683 22.298  1    14.934 ? 1045 LEU A CB     1 ? 
ATOM   551  C CG     . LEU A 1 37  ? 12.669  -11.764 22.746  1    14.286 ? 1045 LEU A CG     1 ? 
ATOM   552  C CD1    . LEU A 1 37  ? 12.789  -12.833 21.669  1    13.14  ? 1045 LEU A CD1    1 ? 
ATOM   553  C CD2    . LEU A 1 37  ? 14.029  -11.132 23.049  1    13.065 ? 1045 LEU A CD2    1 ? 
ATOM   554  H H      . LEU A 1 37  ? 9.743   -11.192 23.971  1    12.788 ? 1045 LEU A H      1 ? 
ATOM   555  H HA     . LEU A 1 37  ? 12.121  -9.429  23.97   1    15.133 ? 1045 LEU A HA     1 c 
ATOM   556  H HB2    . LEU A 1 37  ? 10.784  -11.173 21.893  1    14.788 ? 1045 LEU A HB2    1 c 
ATOM   557  H HB3    . LEU A 1 37  ? 12.135  -10.087 21.509  1    14.804 ? 1045 LEU A HB3    1 c 
ATOM   558  H HG     . LEU A 1 37  ? 12.29   -12.229 23.659  1    13.959 ? 1045 LEU A HG     1 c 
ATOM   559  H HD11   . LEU A 1 37  ? 13.14   -12.378 20.74   1    13.461 ? 1045 LEU A HD11   1 c 
ATOM   560  H HD12   . LEU A 1 37  ? 13.5    -13.597 21.99   1    13.466 ? 1045 LEU A HD12   1 c 
ATOM   561  H HD13   . LEU A 1 37  ? 11.813  -13.294 21.501  1    13.491 ? 1045 LEU A HD13   1 c 
ATOM   562  H HD21   . LEU A 1 37  ? 14.378  -10.581 22.173  1    13.404 ? 1045 LEU A HD21   1 c 
ATOM   563  H HD22   . LEU A 1 37  ? 13.935  -10.448 23.894  1    13.415 ? 1045 LEU A HD22   1 c 
ATOM   564  H HD23   . LEU A 1 37  ? 14.749  -11.915 23.295  1    13.43  ? 1045 LEU A HD23   1 c 
ATOM   565  N N      . VAL A 1 38  ? 9.313   -8.24   23.132  1    18.004 ? 1046 VAL A N      1 ? 
ATOM   566  C CA     . VAL A 1 38  ? 8.534   -7.294  22.352  1    17.923 ? 1046 VAL A CA     1 ? 
ATOM   567  C C      . VAL A 1 38  ? 7.908   -6.232  23.246  1    21.71  ? 1046 VAL A C      1 ? 
ATOM   568  O O      . VAL A 1 38  ? 7.773   -6.397  24.463  1    21.393 ? 1046 VAL A O      1 ? 
ATOM   569  C CB     . VAL A 1 38  ? 7.466   -7.998  21.491  1    18.607 ? 1046 VAL A CB     1 ? 
ATOM   570  C CG1    . VAL A 1 38  ? 8.146   -8.924  20.487  1    18.023 ? 1046 VAL A CG1    1 ? 
ATOM   571  C CG2    . VAL A 1 38  ? 6.454   -8.746  22.359  1    19.032 ? 1046 VAL A CG2    1 ? 
ATOM   572  H H      . VAL A 1 38  ? 8.841   -8.734  23.901  1    18.508 ? 1046 VAL A H      1 ? 
ATOM   573  H HA     . VAL A 1 38  ? 9.218   -6.785  21.671  1    18.733 ? 1046 VAL A HA     1 c 
ATOM   574  H HB     . VAL A 1 38  ? 6.932   -7.225  20.936  1    18.517 ? 1046 VAL A HB     1 c 
ATOM   575  H HG11   . VAL A 1 38  ? 8.828   -8.345  19.86   1    18.187 ? 1046 VAL A HG11   1 c 
ATOM   576  H HG12   . VAL A 1 38  ? 8.708   -9.692  21.021  1    18.187 ? 1046 VAL A HG12   1 c 
ATOM   577  H HG13   . VAL A 1 38  ? 7.391   -9.398  19.858  1    18.201 ? 1046 VAL A HG13   1 c 
ATOM   578  H HG21   . VAL A 1 38  ? 6.979   -9.461  22.997  1    18.908 ? 1046 VAL A HG21   1 c 
ATOM   579  H HG22   . VAL A 1 38  ? 5.91    -8.035  22.983  1    18.923 ? 1046 VAL A HG22   1 c 
ATOM   580  H HG23   . VAL A 1 38  ? 5.749   -9.28   21.719  1    18.903 ? 1046 VAL A HG23   1 c 
ATOM   581  N N      . GLY A 1 39  ? 7.533   -5.123  22.616  1    21.484 ? 1047 GLY A N      1 ? 
ATOM   582  C CA     . GLY A 1 39  ? 6.958   -3.986  23.29   1    22.031 ? 1047 GLY A CA     1 ? 
ATOM   583  C C      . GLY A 1 39  ? 5.435   -4.025  23.245  1    21.635 ? 1047 GLY A C      1 ? 
ATOM   584  O O      . GLY A 1 39  ? 4.818   -4.922  22.665  1    22.575 ? 1047 GLY A O      1 ? 
ATOM   585  H H      . GLY A 1 39  ? 7.598   -5.074  21.584  1    21.759 ? 1047 GLY A H      1 ? 
ATOM   586  H HA2    . GLY A 1 39  ? 7.293   -3.976  24.329  1    21.82  ? 1047 GLY A HA2    1 c 
ATOM   587  H HA3    . GLY A 1 39  ? 7.313   -3.07   22.813  1    21.835 ? 1047 GLY A HA3    1 c 
ATOM   588  N N      . PRO A 1 40  ? 4.795   -3.022  23.873  1    24.847 ? 1048 PRO A N      1 ? 
ATOM   589  C CA     . PRO A 1 40  ? 3.354   -3.076  24.058  1    27.88  ? 1048 PRO A CA     1 ? 
ATOM   590  C C      . PRO A 1 40  ? 2.526   -3.027  22.78   1    28.397 ? 1048 PRO A C      1 ? 
ATOM   591  O O      . PRO A 1 40  ? 1.378   -3.49   22.782  1    30.903 ? 1048 PRO A O      1 ? 
ATOM   592  C CB     . PRO A 1 40  ? 3.052   -1.898  24.98   1    27.541 ? 1048 PRO A CB     1 ? 
ATOM   593  C CG     . PRO A 1 40  ? 4.209   -0.957  24.747  1    27.452 ? 1048 PRO A CG     1 ? 
ATOM   594  C CD     . PRO A 1 40  ? 5.394   -1.842  24.508  1    25.58  ? 1048 PRO A CD     1 ? 
ATOM   595  H HA     . PRO A 1 40  ? 3.109   -3.996  24.592  1    27.311 ? 1048 PRO A HA     1 c 
ATOM   596  H HB2    . PRO A 1 40  ? 2.104   -1.426  24.714  1    27.594 ? 1048 PRO A HB2    1 c 
ATOM   597  H HB3    . PRO A 1 40  ? 3.012   -2.219  26.024  1    27.594 ? 1048 PRO A HB3    1 c 
ATOM   598  H HG2    . PRO A 1 40  ? 4.022   -0.322  23.88   1    27.13  ? 1048 PRO A HG2    1 c 
ATOM   599  H HG3    . PRO A 1 40  ? 4.375   -0.322  25.62   1    27.066 ? 1048 PRO A HG3    1 c 
ATOM   600  H HD2    . PRO A 1 40  ? 6.118   -1.367  23.842  1    25.805 ? 1048 PRO A HD2    1 c 
ATOM   601  H HD3    . PRO A 1 40  ? 5.886   -2.112  25.445  1    25.805 ? 1048 PRO A HD3    1 c 
ATOM   602  N N      . LYS A 1 41  ? 3.055   -2.471  21.688  1    28.11  ? 1049 LYS A N      1 ? 
ATOM   603  C CA     . LYS A 1 41  ? 2.3     -2.42   20.446  1    26.563 ? 1049 LYS A CA     1 ? 
ATOM   604  C C      . LYS A 1 41  ? 2.432   -3.684  19.606  1    29.731 ? 1049 LYS A C      1 ? 
ATOM   605  O O      . LYS A 1 41  ? 1.8     -3.783  18.551  1    25.699 ? 1049 LYS A O      1 ? 
ATOM   606  C CB     . LYS A 1 41  ? 2.722   -1.243  19.563  1    28.604 ? 1049 LYS A CB     1 ? 
ATOM   607  C CG     . LYS A 1 41  ? 1.935   0.049   19.719  1    36.972 ? 1049 LYS A CG     1 ? 
ATOM   608  C CD     . LYS A 1 41  ? 2.106   0.963   18.506  1    44.211 ? 1049 LYS A CD     1 ? 
ATOM   609  C CE     . LYS A 1 41  ? 1.264   2.221   18.509  1    52.084 ? 1049 LYS A CE     1 ? 
ATOM   610  N NZ     . LYS A 1 41  ? 2.067   3.358   18.013  1    58.442 ? 1049 LYS A NZ     1 ? 
ATOM   611  H H      . LYS A 1 41  ? 3.986   -2.017  21.721  1    27.455 ? 1049 LYS A H      1 ? 
ATOM   612  H HA     . LYS A 1 41  ? 1.246   -2.286  20.696  1    27.775 ? 1049 LYS A HA     1 c 
ATOM   613  H HB2    . LYS A 1 41  ? 3.771   -1.024  19.761  1    29.684 ? 1049 LYS A HB2    1 c 
ATOM   614  H HB3    . LYS A 1 41  ? 2.65    -1.554  18.518  1    29.745 ? 1049 LYS A HB3    1 c 
ATOM   615  H HG2    . LYS A 1 41  ? 0.877   -0.194  19.844  1    36.323 ? 1049 LYS A HG2    1 c 
ATOM   616  H HG3    . LYS A 1 41  ? 2.278   0.567   20.617  1    36.323 ? 1049 LYS A HG3    1 c 
ATOM   617  H HD2    . LYS A 1 41  ? 3.158   1.249   18.439  1    44.082 ? 1049 LYS A HD2    1 c 
ATOM   618  H HD3    . LYS A 1 41  ? 1.871   0.389   17.608  1    44.082 ? 1049 LYS A HD3    1 c 
ATOM   619  H HE2    . LYS A 1 41  ? 0.39    2.087   17.869  1    51.582 ? 1049 LYS A HE2    1 c 
ATOM   620  H HE3    . LYS A 1 41  ? 0.923   2.436   19.525  1    51.582 ? 1049 LYS A HE3    1 c 
ATOM   621  H HZ1    . LYS A 1 41  ? 2.195   3.273   17.004  1    55.485 ? 1049 LYS A HZ1    1 ? 
ATOM   622  H HZ2    . LYS A 1 41  ? 1.563   4.219   18.199  1    53.631 ? 1049 LYS A HZ2    1 ? 
ATOM   623  H HZ3    . LYS A 1 41  ? 3.002   3.426   18.472  1    49.409 ? 1049 LYS A HZ3    1 ? 
ATOM   624  N N      . ALA A 1 42  ? 3.242   -4.651  20.029  1    24.51  ? 1050 ALA A N      1 ? 
ATOM   625  C CA     . ALA A 1 42  ? 3.357   -5.879  19.26   1    23.965 ? 1050 ALA A CA     1 ? 
ATOM   626  C C      . ALA A 1 42  ? 2.016   -6.607  19.261  1    25.341 ? 1050 ALA A C      1 ? 
ATOM   627  O O      . ALA A 1 42  ? 1.352   -6.672  20.303  1    29.525 ? 1050 ALA A O      1 ? 
ATOM   628  C CB     . ALA A 1 42  ? 4.434   -6.772  19.858  1    24.699 ? 1050 ALA A CB     1 ? 
ATOM   629  H H      . ALA A 1 42  ? 3.758   -4.545  20.917  1    25.725 ? 1050 ALA A H      1 ? 
ATOM   630  H HA     . ALA A 1 42  ? 3.623   -5.622  18.235  1    24.515 ? 1050 ALA A HA     1 c 
ATOM   631  H HB1    . ALA A 1 42  ? 4.178   -7.015  20.891  1    24.479 ? 1050 ALA A HB1    1 c 
ATOM   632  H HB2    . ALA A 1 42  ? 4.509   -7.695  19.279  1    24.479 ? 1050 ALA A HB2    1 c 
ATOM   633  H HB3    . ALA A 1 42  ? 5.394   -6.253  19.836  1    24.435 ? 1050 ALA A HB3    1 c 
ATOM   634  N N      . PRO A 1 43  ? 1.574   -7.17   18.133  1    27.776 ? 1051 PRO A N      1 ? 
ATOM   635  C CA     . PRO A 1 43  ? 0.28    -7.845  18.095  1    27.481 ? 1051 PRO A CA     1 ? 
ATOM   636  C C      . PRO A 1 43  ? 0.189   -9.096  18.964  1    32.274 ? 1051 PRO A C      1 ? 
ATOM   637  O O      . PRO A 1 43  ? -0.911  -9.554  19.262  1    38.897 ? 1051 PRO A O      1 ? 
ATOM   638  C CB     . PRO A 1 43  ? 0.066   -8.186  16.616  1    27.529 ? 1051 PRO A CB     1 ? 
ATOM   639  C CG     . PRO A 1 43  ? 1.126   -7.412  15.865  1    30.298 ? 1051 PRO A CG     1 ? 
ATOM   640  C CD     . PRO A 1 43  ? 2.23    -7.117  16.81   1    30.098 ? 1051 PRO A CD     1 ? 
ATOM   641  H HA     . PRO A 1 43  ? -0.494  -7.14   18.408  1    28.342 ? 1051 PRO A HA     1 c 
ATOM   642  H HB2    . PRO A 1 43  ? 0.179   -9.259  16.447  1    28.123 ? 1051 PRO A HB2    1 c 
ATOM   643  H HB3    . PRO A 1 43  ? -0.933  -7.888  16.291  1    28.104 ? 1051 PRO A HB3    1 c 
ATOM   644  H HG2    . PRO A 1 43  ? 1.499   -7.999  15.023  1    29.628 ? 1051 PRO A HG2    1 c 
ATOM   645  H HG3    . PRO A 1 43  ? 0.709   -6.481  15.475  1    29.612 ? 1051 PRO A HG3    1 c 
ATOM   646  H HD2    . PRO A 1 43  ? 3.022   -7.866  16.741  1    29.595 ? 1051 PRO A HD2    1 c 
ATOM   647  H HD3    . PRO A 1 43  ? 2.652   -6.128  16.624  1    29.528 ? 1051 PRO A HD3    1 c 
ATOM   648  N N      . GLY A 1 44  ? 1.317   -9.675  19.371  1    31.991 ? 1052 GLY A N      1 ? 
ATOM   649  C CA     . GLY A 1 44  ? 1.324   -10.819 20.249  1    27.922 ? 1052 GLY A CA     1 ? 
ATOM   650  C C      . GLY A 1 44  ? 2.696   -10.896 20.893  1    23.513 ? 1052 GLY A C      1 ? 
ATOM   651  O O      . GLY A 1 44  ? 3.594   -10.131 20.57   1    19.807 ? 1052 GLY A O      1 ? 
ATOM   652  H H      . GLY A 1 44  ? 2.209   -9.391  18.924  1    32.538 ? 1052 GLY A H      1 ? 
ATOM   653  H HA2    . GLY A 1 44  ? 0.554   -10.703 21.014  1    27.888 ? 1052 GLY A HA2    1 c 
ATOM   654  H HA3    . GLY A 1 44  ? 1.118   -11.721 19.683  1    27.923 ? 1052 GLY A HA3    1 c 
ATOM   655  N N      . GLU A 1 45  ? 2.838   -11.832 21.835  1    24.046 ? 1053 GLU A N      1 ? 
ATOM   656  C CA     . GLU A 1 45  ? 4.062   -12.011 22.601  1    19.464 ? 1053 GLU A CA     1 ? 
ATOM   657  C C      . GLU A 1 45  ? 5       -12.969 21.862  1    16.974 ? 1053 GLU A C      1 ? 
ATOM   658  O O      . GLU A 1 45  ? 4.578   -14.018 21.385  1    14.83  ? 1053 GLU A O      1 ? 
ATOM   659  C CB     . GLU A 1 45  ? 3.822   -12.576 24.009  1    21.455 ? 1053 GLU A CB     1 ? 
ATOM   660  C CG     . GLU A 1 45  ? 5.1     -12.655 24.859  1    23.814 ? 1053 GLU A CG     1 ? 
ATOM   661  C CD     . GLU A 1 45  ? 4.986   -13.283 26.257  1    27.532 ? 1053 GLU A CD     1 ? 
ATOM   662  O OE1    . GLU A 1 45  ? 3.871   -13.718 26.627  1    29.63  ? 1053 GLU A OE1    1 ? 
ATOM   663  O OE2    . GLU A 1 45  ? 5.991   -13.354 27      1    26.192 ? 1053 GLU A OE2    1 ? 
ATOM   664  H H      . GLU A 1 45  ? 2.04    -12.463 22.046  1    22.811 ? 1053 GLU A H      1 ? 
ATOM   665  H HA     . GLU A 1 45  ? 4.555   -11.041 22.692  1    20.079 ? 1053 GLU A HA     1 c 
ATOM   666  H HB2    . GLU A 1 45  ? 3.093   -11.945 24.522  1    21.486 ? 1053 GLU A HB2    1 c 
ATOM   667  H HB3    . GLU A 1 45  ? 3.392   -13.576 23.919  1    21.486 ? 1053 GLU A HB3    1 c 
ATOM   668  H HG2    . GLU A 1 45  ? 5.851   -13.215 24.301  1    23.893 ? 1053 GLU A HG2    1 c 
ATOM   669  H HG3    . GLU A 1 45  ? 5.493   -11.644 24.979  1    24.003 ? 1053 GLU A HG3    1 c 
ATOM   670  N N      . THR A 1 46  ? 6.279   -12.593 21.802  1    15.878 ? 1054 THR A N      1 ? 
ATOM   671  C CA     . THR A 1 46  ? 7.345   -13.507 21.445  1    15.748 ? 1054 THR A CA     1 ? 
ATOM   672  C C      . THR A 1 46  ? 8.332   -13.444 22.612  1    14.061 ? 1054 THR A C      1 ? 
ATOM   673  O O      . THR A 1 46  ? 8.673   -12.356 23.086  1    13.631 ? 1054 THR A O      1 ? 
ATOM   674  C CB     . THR A 1 46  ? 8.034   -13.098 20.154  1    17.509 ? 1054 THR A CB     1 ? 
ATOM   675  O OG1    . THR A 1 46  ? 7.082   -13.157 19.089  1    19.274 ? 1054 THR A OG1    1 ? 
ATOM   676  C CG2    . THR A 1 46  ? 9.13    -14.072 19.785  1    18.017 ? 1054 THR A CG2    1 ? 
ATOM   677  H H      . THR A 1 46  ? 6.543   -11.653 22.121  1    16.393 ? 1054 THR A H      1 ? 
ATOM   678  H HA     . THR A 1 46  ? 6.946   -14.516 21.348  1    15.775 ? 1054 THR A HA     1 c 
ATOM   679  H HB     . THR A 1 46  ? 8.438   -12.087 20.238  1    17.592 ? 1054 THR A HB     1 c 
ATOM   680  H HG1    . THR A 1 46  ? 6.511   -12.366 19.127  1    18.671 ? 1054 THR A HG1    1 ? 
ATOM   681  H HG21   . THR A 1 46  ? 9.563   -13.786 18.824  1    17.85  ? 1054 THR A HG21   1 c 
ATOM   682  H HG22   . THR A 1 46  ? 9.908   -14.058 20.551  1    17.832 ? 1054 THR A HG22   1 c 
ATOM   683  H HG23   . THR A 1 46  ? 8.713   -15.078 19.708  1    17.793 ? 1054 THR A HG23   1 c 
ATOM   684  N N      . CYS A 1 47  ? 8.743   -14.624 23.119  1    14.758 ? 1055 CYS A N      1 ? 
ATOM   685  C CA     . CYS A 1 47  ? 9.531   -14.796 24.329  1    15.212 ? 1055 CYS A CA     1 ? 
ATOM   686  C C      . CYS A 1 47  ? 10.898  -15.419 23.978  1    14.855 ? 1055 CYS A C      1 ? 
ATOM   687  O O      . CYS A 1 47  ? 10.995  -16.182 23.014  1    14.388 ? 1055 CYS A O      1 ? 
ATOM   688  C CB     . CYS A 1 47  ? 8.764   -15.694 25.304  1    16.106 ? 1055 CYS A CB     1 ? 
ATOM   689  S SG     . CYS A 1 47  ? 6.978   -15.675 24.93   1    17.98  ? 1055 CYS A SG     1 ? 
ATOM   690  H H      . CYS A 1 47  ? 8.459   -15.47  22.596  1    14.924 ? 1055 CYS A H      1 ? 
ATOM   691  H HA     . CYS A 1 47  ? 9.694   -13.815 24.778  1    15.209 ? 1055 CYS A HA     1 c 
ATOM   692  H HB2    . CYS A 1 47  ? 9.133   -16.718 25.228  1    16.249 ? 1055 CYS A HB2    1 c 
ATOM   693  H HB3    . CYS A 1 47  ? 8.919   -15.344 26.327  1    16.226 ? 1055 CYS A HB3    1 c 
ATOM   694  N N      . HIS A 1 48  ? 11.961  -15.01  24.73   1    16.367 ? 1056 HIS A N      1 ? 
ATOM   695  C CA     . HIS A 1 48  ? 13.287  -15.615 24.695  1    14.636 ? 1056 HIS A CA     1 ? 
ATOM   696  C C      . HIS A 1 48  ? 13.401  -16.547 25.904  1    14.069 ? 1056 HIS A C      1 ? 
ATOM   697  O O      . HIS A 1 48  ? 13.24   -16.103 27.046  1    13.33  ? 1056 HIS A O      1 ? 
ATOM   698  C CB     . HIS A 1 48  ? 14.356  -14.521 24.776  1    14.558 ? 1056 HIS A CB     1 ? 
ATOM   699  C CG     . HIS A 1 48  ? 15.727  -14.989 24.474  1    13.784 ? 1056 HIS A CG     1 ? 
ATOM   700  N ND1    . HIS A 1 48  ? 16.149  -15.287 23.196  1    12.887 ? 1056 HIS A ND1    1 ? 
ATOM   701  C CD2    . HIS A 1 48  ? 16.801  -15.184 25.3    1    13.554 ? 1056 HIS A CD2    1 ? 
ATOM   702  C CE1    . HIS A 1 48  ? 17.427  -15.671 23.24   1    13.051 ? 1056 HIS A CE1    1 ? 
ATOM   703  N NE2    . HIS A 1 48  ? 17.841  -15.61  24.499  1    13.506 ? 1056 HIS A NE2    1 ? 
ATOM   704  H H      . HIS A 1 48  ? 11.804  -14.208 25.365  1    16.477 ? 1056 HIS A H      1 ? 
ATOM   705  H HA     . HIS A 1 48  ? 13.402  -16.198 23.781  1    14.805 ? 1056 HIS A HA     1 c 
ATOM   706  H HB2    . HIS A 1 48  ? 14.092  -13.726 24.076  1    14.374 ? 1056 HIS A HB2    1 c 
ATOM   707  H HB3    . HIS A 1 48  ? 14.342  -14.094 25.781  1    14.392 ? 1056 HIS A HB3    1 c 
ATOM   708  H HD2    . HIS A 1 48  ? 16.84   -15.029 26.373  1    13.598 ? 1056 HIS A HD2    1 c 
ATOM   709  H HE1    . HIS A 1 48  ? 18.027  -15.969 22.387  1    13.132 ? 1056 HIS A HE1    1 c 
ATOM   710  H HE2    . HIS A 1 48  ? 18.777  -15.811 24.859  1    14.821 ? 1056 HIS A HE2    1 ? 
ATOM   711  N N      . ILE A 1 49  ? 13.628  -17.826 25.636  1    14.734 ? 1057 ILE A N      1 ? 
ATOM   712  C CA     . ILE A 1 49  ? 13.652  -18.881 26.646  1    16.456 ? 1057 ILE A CA     1 ? 
ATOM   713  C C      . ILE A 1 49  ? 15.097  -19.38  26.735  1    14.635 ? 1057 ILE A C      1 ? 
ATOM   714  O O      . ILE A 1 49  ? 15.64   -19.847 25.729  1    13.985 ? 1057 ILE A O      1 ? 
ATOM   715  C CB     . ILE A 1 49  ? 12.77   -20.069 26.227  1    18.756 ? 1057 ILE A CB     1 ? 
ATOM   716  C CG1    . ILE A 1 49  ? 11.471  -19.66  25.511  1    20.71  ? 1057 ILE A CG1    1 ? 
ATOM   717  C CG2    . ILE A 1 49  ? 12.593  -21.01  27.425  1    17.988 ? 1057 ILE A CG2    1 ? 
ATOM   718  C CD1    . ILE A 1 49  ? 10.548  -18.955 26.441  1    21.517 ? 1057 ILE A CD1    1 ? 
ATOM   719  H H      . ILE A 1 49  ? 13.823  -18.069 24.648  1    14.738 ? 1057 ILE A H      1 ? 
ATOM   720  H HA     . ILE A 1 49  ? 13.325  -18.489 27.611  1    16.139 ? 1057 ILE A HA     1 c 
ATOM   721  H HB     . ILE A 1 49  ? 13.348  -20.628 25.489  1    18.451 ? 1057 ILE A HB     1 c 
ATOM   722  H HG12   . ILE A 1 49  ? 11.709  -19.006 24.67   1    20.405 ? 1057 ILE A HG12   1 c 
ATOM   723  H HG13   . ILE A 1 49  ? 10.978  -20.554 25.122  1    20.439 ? 1057 ILE A HG13   1 c 
ATOM   724  H HG21   . ILE A 1 49  ? 11.935  -21.836 27.146  1    18.173 ? 1057 ILE A HG21   1 c 
ATOM   725  H HG22   . ILE A 1 49  ? 13.564  -21.407 27.727  1    18.157 ? 1057 ILE A HG22   1 c 
ATOM   726  H HG23   . ILE A 1 49  ? 12.15   -20.461 28.259  1    18.115 ? 1057 ILE A HG23   1 c 
ATOM   727  H HD11   . ILE A 1 49  ? 11.03   -18.053 26.824  1    21.222 ? 1057 ILE A HD11   1 c 
ATOM   728  H HD12   . ILE A 1 49  ? 9.636   -18.678 25.907  1    21.206 ? 1057 ILE A HD12   1 c 
ATOM   729  H HD13   . ILE A 1 49  ? 10.292  -19.611 27.276  1    21.173 ? 1057 ILE A HD13   1 c 
ATOM   730  N N      . VAL A 1 50  ? 15.703  -19.333 27.926  1    14.645 ? 1058 VAL A N      1 ? 
ATOM   731  C CA     . VAL A 1 50  ? 17.038  -19.872 28.142  1    15.179 ? 1058 VAL A CA     1 ? 
ATOM   732  C C      . VAL A 1 50  ? 16.922  -21.157 28.959  1    13.745 ? 1058 VAL A C      1 ? 
ATOM   733  O O      . VAL A 1 50  ? 16.287  -21.171 30.024  1    13.652 ? 1058 VAL A O      1 ? 
ATOM   734  C CB     . VAL A 1 50  ? 17.961  -18.858 28.843  1    13.821 ? 1058 VAL A CB     1 ? 
ATOM   735  C CG1    . VAL A 1 50  ? 19.352  -19.432 29.02   1    13.323 ? 1058 VAL A CG1    1 ? 
ATOM   736  C CG2    . VAL A 1 50  ? 17.992  -17.543 28.059  1    15.318 ? 1058 VAL A CG2    1 ? 
ATOM   737  H H      . VAL A 1 50  ? 15.182  -18.941 28.734  1    14.031 ? 1058 VAL A H      1 ? 
ATOM   738  H HA     . VAL A 1 50  ? 17.472  -20.118 27.171  1    14.563 ? 1058 VAL A HA     1 c 
ATOM   739  H HB     . VAL A 1 50  ? 17.541  -18.661 29.832  1    14.221 ? 1058 VAL A HB     1 c 
ATOM   740  H HG11   . VAL A 1 50  ? 19.313  -20.288 29.697  1    13.468 ? 1058 VAL A HG11   1 c 
ATOM   741  H HG12   . VAL A 1 50  ? 19.74   -19.753 28.051  1    13.467 ? 1058 VAL A HG12   1 c 
ATOM   742  H HG13   . VAL A 1 50  ? 20.01   -18.669 29.44   1    13.489 ? 1058 VAL A HG13   1 c 
ATOM   743  H HG21   . VAL A 1 50  ? 16.982  -17.135 27.991  1    14.882 ? 1058 VAL A HG21   1 c 
ATOM   744  H HG22   . VAL A 1 50  ? 18.638  -16.828 28.572  1    14.886 ? 1058 VAL A HG22   1 c 
ATOM   745  H HG23   . VAL A 1 50  ? 18.378  -17.726 27.055  1    14.882 ? 1058 VAL A HG23   1 c 
ATOM   746  N N      . ILE A 1 51  ? 17.537  -22.233 28.448  1    13.294 ? 1059 ILE A N      1 ? 
ATOM   747  C CA     . ILE A 1 51  ? 17.36   -23.586 28.957  1    14.798 ? 1059 ILE A CA     1 ? 
ATOM   748  C C      . ILE A 1 51  ? 18.722  -24.163 29.308  1    15.528 ? 1059 ILE A C      1 ? 
ATOM   749  O O      . ILE A 1 51  ? 19.622  -24.189 28.454  1    12.326 ? 1059 ILE A O      1 ? 
ATOM   750  C CB     . ILE A 1 51  ? 16.682  -24.476 27.9    1    14.534 ? 1059 ILE A CB     1 ? 
ATOM   751  C CG1    . ILE A 1 51  ? 15.313  -23.93  27.513  1    15.25  ? 1059 ILE A CG1    1 ? 
ATOM   752  C CG2    . ILE A 1 51  ? 16.61   -25.922 28.392  1    14.801 ? 1059 ILE A CG2    1 ? 
ATOM   753  C CD1    . ILE A 1 51  ? 14.804  -24.532 26.19   1    15.275 ? 1059 ILE A CD1    1 ? 
ATOM   754  H H      . ILE A 1 51  ? 18.143  -22.074 27.621  1    14.066 ? 1059 ILE A H      1 ? 
ATOM   755  H HA     . ILE A 1 51  ? 16.738  -23.555 29.853  1    14.57  ? 1059 ILE A HA     1 c 
ATOM   756  H HB     . ILE A 1 51  ? 17.307  -24.46  27.005  1    14.757 ? 1059 ILE A HB     1 c 
ATOM   757  H HG12   . ILE A 1 51  ? 14.6    -24.158 28.308  1    15.092 ? 1059 ILE A HG12   1 c 
ATOM   758  H HG13   . ILE A 1 51  ? 15.374  -22.845 27.411  1    15.077 ? 1059 ILE A HG13   1 c 
ATOM   759  H HG21   . ILE A 1 51  ? 16.124  -25.952 29.369  1    14.73  ? 1059 ILE A HG21   1 c 
ATOM   760  H HG22   . ILE A 1 51  ? 16.034  -26.522 27.684  1    14.736 ? 1059 ILE A HG22   1 c 
ATOM   761  H HG23   . ILE A 1 51  ? 17.618  -26.334 28.477  1    14.735 ? 1059 ILE A HG23   1 c 
ATOM   762  H HD11   . ILE A 1 51  ? 14.794  -25.621 26.257  1    15.371 ? 1059 ILE A HD11   1 c 
ATOM   763  H HD12   . ILE A 1 51  ? 13.792  -24.173 25.991  1    15.289 ? 1059 ILE A HD12   1 c 
ATOM   764  H HD13   . ILE A 1 51  ? 15.463  -24.227 25.375  1    15.273 ? 1059 ILE A HD13   1 c 
ATOM   765  N N      . ASP A 1 52  ? 18.866  -24.65  30.546  1    13.712 ? 1060 ASP A N      1 ? 
ATOM   766  C CA     . ASP A 1 52  ? 20.095  -25.303 30.989  1    13.509 ? 1060 ASP A CA     1 ? 
ATOM   767  C C      . ASP A 1 52  ? 20.004  -26.79  30.64   1    14.029 ? 1060 ASP A C      1 ? 
ATOM   768  O O      . ASP A 1 52  ? 19.197  -27.522 31.221  1    12.527 ? 1060 ASP A O      1 ? 
ATOM   769  C CB     . ASP A 1 52  ? 20.305  -25.04  32.484  1    15.862 ? 1060 ASP A CB     1 ? 
ATOM   770  C CG     . ASP A 1 52  ? 21.548  -25.707 33.055  1    15.763 ? 1060 ASP A CG     1 ? 
ATOM   771  O OD1    . ASP A 1 52  ? 21.996  -26.584 32.289  1    15.173 ? 1060 ASP A OD1    1 ? 
ATOM   772  O OD2    . ASP A 1 52  ? 22.036  -25.517 34.197  1    18.95  ? 1060 ASP A OD2    1 ? 
ATOM   773  H H      . ASP A 1 52  ? 18.043  -24.673 31.18   1    13.839 ? 1060 ASP A H      1 ? 
ATOM   774  H HA     . ASP A 1 52  ? 20.935  -24.865 30.446  1    14.025 ? 1060 ASP A HA     1 c 
ATOM   775  H HB2    . ASP A 1 52  ? 20.386  -23.964 32.647  1    15.297 ? 1060 ASP A HB2    1 c 
ATOM   776  H HB3    . ASP A 1 52  ? 19.434  -25.403 33.035  1    15.298 ? 1060 ASP A HB3    1 c 
ATOM   777  N N      . HIS A 1 53  ? 20.803  -27.224 29.66   1    13.92  ? 1061 HIS A N      1 ? 
ATOM   778  C CA     . HIS A 1 53  ? 20.91   -28.626 29.285  1    13.026 ? 1061 HIS A CA     1 ? 
ATOM   779  C C      . HIS A 1 53  ? 22.134  -29.298 29.904  1    14.032 ? 1061 HIS A C      1 ? 
ATOM   780  O O      . HIS A 1 53  ? 22.353  -30.491 29.677  1    14.359 ? 1061 HIS A O      1 ? 
ATOM   781  C CB     . HIS A 1 53  ? 20.901  -28.815 27.759  1    13.324 ? 1061 HIS A CB     1 ? 
ATOM   782  C CG     . HIS A 1 53  ? 22.068  -28.239 27.054  1    14.479 ? 1061 HIS A CG     1 ? 
ATOM   783  N ND1    . HIS A 1 53  ? 23.225  -28.955 26.836  1    14.912 ? 1061 HIS A ND1    1 ? 
ATOM   784  C CD2    . HIS A 1 53  ? 22.246  -27.026 26.463  1    13.792 ? 1061 HIS A CD2    1 ? 
ATOM   785  C CE1    . HIS A 1 53  ? 24.083  -28.193 26.159  1    13.953 ? 1061 HIS A CE1    1 ? 
ATOM   786  N NE2    . HIS A 1 53  ? 23.517  -27.016 25.932  1    14.468 ? 1061 HIS A NE2    1 ? 
ATOM   787  H H      . HIS A 1 53  ? 21.401  -26.534 29.17   1    14.484 ? 1061 HIS A H      1 ? 
ATOM   788  H HA     . HIS A 1 53  ? 20.024  -29.127 29.675  1    13.431 ? 1061 HIS A HA     1 c 
ATOM   789  H HB2    . HIS A 1 53  ? 20.853  -29.884 27.543  1    13.509 ? 1061 HIS A HB2    1 c 
ATOM   790  H HB3    . HIS A 1 53  ? 19.991  -28.363 27.36   1    13.509 ? 1061 HIS A HB3    1 c 
ATOM   791  H HD2    . HIS A 1 53  ? 21.536  -26.206 26.43   1    14.084 ? 1061 HIS A HD2    1 c 
ATOM   792  H HE1    . HIS A 1 53  ? 25.081  -28.487 25.858  1    14.287 ? 1061 HIS A HE1    1 c 
ATOM   793  H HE2    . HIS A 1 53  ? 23.925  -26.247 25.421  1    15.108 ? 1061 HIS A HE2    1 ? 
ATOM   794  N N      . GLY A 1 54  ? 22.915  -28.562 30.684  1    14.717 ? 1062 GLY A N      1 ? 
ATOM   795  C CA     . GLY A 1 54  ? 24.022  -29.121 31.429  1    17.041 ? 1062 GLY A CA     1 ? 
ATOM   796  C C      . GLY A 1 54  ? 25.196  -29.582 30.572  1    16.326 ? 1062 GLY A C      1 ? 
ATOM   797  O O      . GLY A 1 54  ? 26.093  -30.222 31.099  1    17.15  ? 1062 GLY A O      1 ? 
ATOM   798  H H      . GLY A 1 54  ? 22.645  -27.593 30.926  1    14.795 ? 1062 GLY A H      1 ? 
ATOM   799  H HA2    . GLY A 1 54  ? 24.374  -28.374 32.139  1    16.42  ? 1062 GLY A HA2    1 c 
ATOM   800  H HA3    . GLY A 1 54  ? 23.652  -29.972 32.003  1    16.364 ? 1062 GLY A HA3    1 c 
ATOM   801  N N      . GLY A 1 55  ? 25.222  -29.238 29.282  1    14.958 ? 1063 GLY A N      1 ? 
ATOM   802  C CA     . GLY A 1 55  ? 26.187  -29.813 28.384  1    14.058 ? 1063 GLY A CA     1 ? 
ATOM   803  C C      . GLY A 1 55  ? 25.795  -31.184 27.855  1    14.776 ? 1063 GLY A C      1 ? 
ATOM   804  O O      . GLY A 1 55  ? 26.559  -31.78  27.084  1    13.446 ? 1063 GLY A O      1 ? 
ATOM   805  H H      . GLY A 1 55  ? 24.487  -28.632 28.884  1    14.659 ? 1063 GLY A H      1 ? 
ATOM   806  H HA2    . GLY A 1 55  ? 26.326  -29.132 27.541  1    14.412 ? 1063 GLY A HA2    1 c 
ATOM   807  H HA3    . GLY A 1 55  ? 27.145  -29.891 28.903  1    14.402 ? 1063 GLY A HA3    1 c 
ATOM   808  N N      . ASN A 1 56  ? 24.624  -31.693 28.26   1    14.291 ? 1064 ASN A N      1 ? 
ATOM   809  C CA     . ASN A 1 56  ? 24.18   -33.007 27.838  1    14.592 ? 1064 ASN A CA     1 ? 
ATOM   810  C C      . ASN A 1 56  ? 23.506  -33.014 26.469  1    13.663 ? 1064 ASN A C      1 ? 
ATOM   811  O O      . ASN A 1 56  ? 23.373  -34.085 25.87   1    13.793 ? 1064 ASN A O      1 ? 
ATOM   812  C CB     . ASN A 1 56  ? 23.192  -33.565 28.848  1    16.115 ? 1064 ASN A CB     1 ? 
ATOM   813  C CG     . ASN A 1 56  ? 23.844  -33.792 30.181  1    16.637 ? 1064 ASN A CG     1 ? 
ATOM   814  O OD1    . ASN A 1 56  ? 24.612  -34.749 30.334  1    19.175 ? 1064 ASN A OD1    1 ? 
ATOM   815  N ND2    . ASN A 1 56  ? 23.582  -32.91  31.133  1    17.231 ? 1064 ASN A ND2    1 ? 
ATOM   816  H H      . ASN A 1 56  ? 23.942  -31.105 28.747  1    15.134 ? 1064 ASN A H      1 ? 
ATOM   817  H HA     . ASN A 1 56  ? 25.044  -33.674 27.811  1    14.619 ? 1064 ASN A HA     1 c 
ATOM   818  H HB2    . ASN A 1 56  ? 22.361  -32.868 28.965  1    15.885 ? 1064 ASN A HB2    1 c 
ATOM   819  H HB3    . ASN A 1 56  ? 22.793  -34.511 28.476  1    15.882 ? 1064 ASN A HB3    1 c 
ATOM   820  H HD21   . ASN A 1 56  ? 24.055  -32.918 32.025  1    17.329 ? 1064 ASN A HD21   1 ? 
ATOM   821  H HD22   . ASN A 1 56  ? 22.949  -32.163 30.933  1    17.496 ? 1064 ASN A HD22   1 ? 
ATOM   822  N N      . VAL A 1 57  ? 23.053  -31.857 25.985  1    13.546 ? 1065 VAL A N      1 ? 
ATOM   823  C CA     . VAL A 1 57  ? 22.364  -31.798 24.703  1    13.544 ? 1065 VAL A CA     1 ? 
ATOM   824  C C      . VAL A 1 57  ? 23.028  -30.741 23.82   1    13.37  ? 1065 VAL A C      1 ? 
ATOM   825  O O      . VAL A 1 57  ? 22.39   -29.756 23.41   1    12.569 ? 1065 VAL A O      1 ? 
ATOM   826  C CB     . VAL A 1 57  ? 20.841  -31.603 24.841  1    13.232 ? 1065 VAL A CB     1 ? 
ATOM   827  C CG1    . VAL A 1 57  ? 20.156  -32.093 23.562  1    12.355 ? 1065 VAL A CG1    1 ? 
ATOM   828  C CG2    . VAL A 1 57  ? 20.299  -32.351 26.076  1    13.474 ? 1065 VAL A CG2    1 ? 
ATOM   829  H H      . VAL A 1 57  ? 23.247  -30.99  26.502  1    13.331 ? 1065 VAL A H      1 ? 
ATOM   830  H HA     . VAL A 1 57  ? 22.516  -32.761 24.213  1    13.455 ? 1065 VAL A HA     1 c 
ATOM   831  H HB     . VAL A 1 57  ? 20.649  -30.535 24.961  1    13.164 ? 1065 VAL A HB     1 c 
ATOM   832  H HG11   . VAL A 1 57  ? 20.31   -33.169 23.455  1    12.602 ? 1065 VAL A HG11   1 c 
ATOM   833  H HG12   . VAL A 1 57  ? 19.086  -31.883 23.618  1    12.602 ? 1065 VAL A HG12   1 c 
ATOM   834  H HG13   . VAL A 1 57  ? 20.582  -31.579 22.699  1    12.635 ? 1065 VAL A HG13   1 c 
ATOM   835  H HG21   . VAL A 1 57  ? 19.213  -32.242 26.121  1    13.412 ? 1065 VAL A HG21   1 c 
ATOM   836  H HG22   . VAL A 1 57  ? 20.555  -33.409 26.003  1    13.423 ? 1065 VAL A HG22   1 c 
ATOM   837  H HG23   . VAL A 1 57  ? 20.743  -31.933 26.982  1    13.416 ? 1065 VAL A HG23   1 c 
ATOM   838  N N      . PRO A 1 58  ? 24.314  -30.926 23.487  1    12.329 ? 1066 PRO A N      1 ? 
ATOM   839  C CA     . PRO A 1 58  ? 24.976  -29.994 22.589  1    12.907 ? 1066 PRO A CA     1 ? 
ATOM   840  C C      . PRO A 1 58  ? 24.383  -30.03  21.187  1    13.027 ? 1066 PRO A C      1 ? 
ATOM   841  O O      . PRO A 1 58  ? 23.718  -30.988 20.783  1    13.858 ? 1066 PRO A O      1 ? 
ATOM   842  C CB     . PRO A 1 58  ? 26.426  -30.475 22.588  1    12.648 ? 1066 PRO A CB     1 ? 
ATOM   843  C CG     . PRO A 1 58  ? 26.293  -31.946 22.843  1    12.202 ? 1066 PRO A CG     1 ? 
ATOM   844  C CD     . PRO A 1 58  ? 25.173  -32.069 23.835  1    12.204 ? 1066 PRO A CD     1 ? 
ATOM   845  H HA     . PRO A 1 58  ? 24.911  -28.982 22.995  1    12.782 ? 1066 PRO A HA     1 c 
ATOM   846  H HB2    . PRO A 1 58  ? 26.902  -30.285 21.623  1    12.608 ? 1066 PRO A HB2    1 c 
ATOM   847  H HB3    . PRO A 1 58  ? 27.003  -29.991 23.377  1    12.627 ? 1066 PRO A HB3    1 c 
ATOM   848  H HG2    . PRO A 1 58  ? 26.051  -32.48  21.922  1    12.317 ? 1066 PRO A HG2    1 c 
ATOM   849  H HG3    . PRO A 1 58  ? 27.217  -32.355 23.255  1    12.395 ? 1066 PRO A HG3    1 c 
ATOM   850  H HD2    . PRO A 1 58  ? 24.635  -33.012 23.716  1    12.24  ? 1066 PRO A HD2    1 c 
ATOM   851  H HD3    . PRO A 1 58  ? 25.536  -31.984 24.86   1    12.246 ? 1066 PRO A HD3    1 c 
ATOM   852  N N      . TYR A 1 59  ? 24.683  -28.987 20.422  1    12.558 ? 1067 TYR A N      1 ? 
ATOM   853  C CA     . TYR A 1 59  ? 24.114  -28.796 19.1    1    13.269 ? 1067 TYR A CA     1 ? 
ATOM   854  C C      . TYR A 1 59  ? 25.042  -27.888 18.305  1    13.121 ? 1067 TYR A C      1 ? 
ATOM   855  O O      . TYR A 1 59  ? 25.965  -27.264 18.851  1    12.015 ? 1067 TYR A O      1 ? 
ATOM   856  C CB     . TYR A 1 59  ? 22.712  -28.166 19.181  1    12.76  ? 1067 TYR A CB     1 ? 
ATOM   857  C CG     . TYR A 1 59  ? 22.71   -26.878 19.98   1    12.544 ? 1067 TYR A CG     1 ? 
ATOM   858  C CD1    . TYR A 1 59  ? 22.555  -26.906 21.355  1    11.714 ? 1067 TYR A CD1    1 ? 
ATOM   859  C CD2    . TYR A 1 59  ? 22.947  -25.648 19.367  1    12.698 ? 1067 TYR A CD2    1 ? 
ATOM   860  C CE1    . TYR A 1 59  ? 22.565  -25.736 22.099  1    13.059 ? 1067 TYR A CE1    1 ? 
ATOM   861  C CE2    . TYR A 1 59  ? 22.984  -24.486 20.089  1    12.636 ? 1067 TYR A CE2    1 ? 
ATOM   862  C CZ     . TYR A 1 59  ? 22.822  -24.517 21.47   1    13.864 ? 1067 TYR A CZ     1 ? 
ATOM   863  O OH     . TYR A 1 59  ? 22.858  -23.359 22.216  1    13.763 ? 1067 TYR A OH     1 ? 
ATOM   864  H H      . TYR A 1 59  ? 25.382  -28.296 20.749  1    13.2   ? 1067 TYR A H      1 ? 
ATOM   865  H HA     . TYR A 1 59  ? 24.044  -29.764 18.599  1    13.022 ? 1067 TYR A HA     1 c 
ATOM   866  H HB2    . TYR A 1 59  ? 22.359  -27.961 18.168  1    12.82  ? 1067 TYR A HB2    1 c 
ATOM   867  H HB3    . TYR A 1 59  ? 22.03   -28.88  19.648  1    12.82  ? 1067 TYR A HB3    1 c 
ATOM   868  H HD1    . TYR A 1 59  ? 22.374  -27.852 21.853  1    12.203 ? 1067 TYR A HD1    1 c 
ATOM   869  H HD2    . TYR A 1 59  ? 23.099  -25.609 18.294  1    12.668 ? 1067 TYR A HD2    1 c 
ATOM   870  H HE1    . TYR A 1 59  ? 22.44   -25.774 23.176  1    12.915 ? 1067 TYR A HE1    1 c 
ATOM   871  H HE2    . TYR A 1 59  ? 23.167  -23.541 19.588  1    12.904 ? 1067 TYR A HE2    1 c 
ATOM   872  H HH     . TYR A 1 59  ? 23.419  -22.758 21.728  1    14.184 ? 1067 TYR A HH     1 ? 
ATOM   873  N N      . TRP A 1 60  ? 24.781  -27.826 16.999  1    12.871 ? 1068 TRP A N      1 ? 
ATOM   874  C CA     . TRP A 1 60  ? 25.411  -26.854 16.125  1    14.425 ? 1068 TRP A CA     1 ? 
ATOM   875  C C      . TRP A 1 60  ? 24.415  -25.754 15.778  1    14.769 ? 1068 TRP A C      1 ? 
ATOM   876  O O      . TRP A 1 60  ? 23.19   -25.943 15.806  1    14.389 ? 1068 TRP A O      1 ? 
ATOM   877  C CB     . TRP A 1 60  ? 25.907  -27.519 14.841  1    14.912 ? 1068 TRP A CB     1 ? 
ATOM   878  C CG     . TRP A 1 60  ? 27.143  -28.352 15.017  1    15.872 ? 1068 TRP A CG     1 ? 
ATOM   879  C CD1    . TRP A 1 60  ? 27.73   -28.733 16.184  1    16.161 ? 1068 TRP A CD1    1 ? 
ATOM   880  C CD2    . TRP A 1 60  ? 27.92   -28.917 13.953  1    15.107 ? 1068 TRP A CD2    1 ? 
ATOM   881  N NE1    . TRP A 1 60  ? 28.826  -29.51  15.916  1    16.301 ? 1068 TRP A NE1    1 ? 
ATOM   882  C CE2    . TRP A 1 60  ? 28.964  -29.648 14.558  1    15.477 ? 1068 TRP A CE2    1 ? 
ATOM   883  C CE3    . TRP A 1 60  ? 27.829  -28.872 12.567  1    14.768 ? 1068 TRP A CE3    1 ? 
ATOM   884  C CZ2    . TRP A 1 60  ? 29.922  -30.329 13.815  1    16.261 ? 1068 TRP A CZ2    1 ? 
ATOM   885  C CZ3    . TRP A 1 60  ? 28.781  -29.539 11.823  1    15.794 ? 1068 TRP A CZ3    1 ? 
ATOM   886  C CH2    . TRP A 1 60  ? 29.815  -30.26  12.442  1    16.428 ? 1068 TRP A CH2    1 ? 
ATOM   887  H H      . TRP A 1 60  ? 24.04   -28.45  16.616  1    12.986 ? 1068 TRP A H      1 ? 
ATOM   888  H HA     . TRP A 1 60  ? 26.264  -26.412 16.643  1    14.246 ? 1068 TRP A HA     1 c 
ATOM   889  H HB2    . TRP A 1 60  ? 25.109  -28.152 14.448  1    15.01  ? 1068 TRP A HB2    1 c 
ATOM   890  H HB3    . TRP A 1 60  ? 26.109  -26.74  14.104  1    15.01  ? 1068 TRP A HB3    1 c 
ATOM   891  H HD1    . TRP A 1 60  ? 27.392  -28.477 17.18   1    16.051 ? 1068 TRP A HD1    1 c 
ATOM   892  H HE1    . TRP A 1 60  ? 29.381  -29.854 16.669  1    16.653 ? 1068 TRP A HE1    1 ? 
ATOM   893  H HE3    . TRP A 1 60  ? 27.034  -28.316 12.082  1    15.086 ? 1068 TRP A HE3    1 c 
ATOM   894  H HZ2    . TRP A 1 60  ? 30.723  -30.878 14.296  1    16.155 ? 1068 TRP A HZ2    1 c 
ATOM   895  H HZ3    . TRP A 1 60  ? 28.72   -29.519 10.74   1    15.696 ? 1068 TRP A HZ3    1 c 
ATOM   896  H HH2    . TRP A 1 60  ? 30.54   -30.783 11.827  1    16.231 ? 1068 TRP A HH2    1 c 
ATOM   897  N N      . GLU A 1 61  ? 24.961  -24.59  15.41   1    13.905 ? 1069 GLU A N      1 ? 
ATOM   898  C CA     . GLU A 1 61  ? 24.132  -23.482 14.995  1    12.651 ? 1069 GLU A CA     1 ? 
ATOM   899  C C      . GLU A 1 61  ? 23.223  -23.912 13.847  1    13.27  ? 1069 GLU A C      1 ? 
ATOM   900  O O      . GLU A 1 61  ? 23.637  -24.631 12.945  1    12.26  ? 1069 GLU A O      1 ? 
ATOM   901  C CB     . GLU A 1 61  ? 25.024  -22.304 14.592  1    12.175 ? 1069 GLU A CB     1 ? 
ATOM   902  C CG     . GLU A 1 61  ? 25.785  -21.67  15.769  1    11.953 ? 1069 GLU A CG     1 ? 
ATOM   903  C CD     . GLU A 1 61  ? 27.026  -22.464 16.223  1    11.306 ? 1069 GLU A CD     1 ? 
ATOM   904  O OE1    . GLU A 1 61  ? 27.513  -23.34  15.473  1    11.556 ? 1069 GLU A OE1    1 ? 
ATOM   905  O OE2    . GLU A 1 61  ? 27.508  -22.195 17.346  1    11.554 ? 1069 GLU A OE2    1 ? 
ATOM   906  H H      . GLU A 1 61  ? 25.984  -24.451 15.332  1    13.564 ? 1069 GLU A H      1 ? 
ATOM   907  H HA     . GLU A 1 61  ? 23.51   -23.182 15.842  1    12.903 ? 1069 GLU A HA     1 c 
ATOM   908  H HB2    . GLU A 1 61  ? 25.74   -22.647 13.843  1    12.372 ? 1069 GLU A HB2    1 c 
ATOM   909  H HB3    . GLU A 1 61  ? 24.401  -21.537 14.128  1    12.257 ? 1069 GLU A HB3    1 c 
ATOM   910  H HG2    . GLU A 1 61  ? 26.102  -20.664 15.487  1    11.855 ? 1069 GLU A HG2    1 c 
ATOM   911  H HG3    . GLU A 1 61  ? 25.106  -21.576 16.618  1    11.849 ? 1069 GLU A HG3    1 c 
ATOM   912  N N      . GLY A 1 62  ? 21.962  -23.464 13.914  1    13.682 ? 1070 GLY A N      1 ? 
ATOM   913  C CA     . GLY A 1 62  ? 21.004  -23.782 12.873  1    13.367 ? 1070 GLY A CA     1 ? 
ATOM   914  C C      . GLY A 1 62  ? 20.153  -25.012 13.157  1    13.619 ? 1070 GLY A C      1 ? 
ATOM   915  O O      . GLY A 1 62  ? 19.203  -25.268 12.413  1    14.977 ? 1070 GLY A O      1 ? 
ATOM   916  H H      . GLY A 1 62  ? 21.66   -22.891 14.718  1    13.402 ? 1070 GLY A H      1 ? 
ATOM   917  H HA2    . GLY A 1 62  ? 20.345  -22.921 12.737  1    13.499 ? 1070 GLY A HA2    1 c 
ATOM   918  H HA3    . GLY A 1 62  ? 21.54   -23.931 11.937  1    13.523 ? 1070 GLY A HA3    1 c 
ATOM   919  N N      . GLN A 1 63  ? 20.46   -25.771 14.206  1    13.333 ? 1071 GLN A N      1 ? 
ATOM   920  C CA     . GLN A 1 63  ? 19.658  -26.928 14.55   1    12.717 ? 1071 GLN A CA     1 ? 
ATOM   921  C C      . GLN A 1 63  ? 18.437  -26.517 15.375  1    12.235 ? 1071 GLN A C      1 ? 
ATOM   922  O O      . GLN A 1 63  ? 18.278  -25.351 15.755  1    13.64  ? 1071 GLN A O      1 ? 
ATOM   923  C CB     . GLN A 1 63  ? 20.511  -27.947 15.289  1    12.16  ? 1071 GLN A CB     1 ? 
ATOM   924  C CG     . GLN A 1 63  ? 21.602  -28.538 14.406  1    12.047 ? 1071 GLN A CG     1 ? 
ATOM   925  C CD     . GLN A 1 63  ? 22.179  -29.783 15.043  1    13.186 ? 1071 GLN A CD     1 ? 
ATOM   926  O OE1    . GLN A 1 63  ? 22.923  -29.696 16.022  1    12.965 ? 1071 GLN A OE1    1 ? 
ATOM   927  N NE2    . GLN A 1 63  ? 21.851  -30.946 14.502  1    13.69  ? 1071 GLN A NE2    1 ? 
ATOM   928  H H      . GLN A 1 63  ? 21.261  -25.529 14.813  1    13.484 ? 1071 GLN A H      1 ? 
ATOM   929  H HA     . GLN A 1 63  ? 19.308  -27.387 13.623  1    12.656 ? 1071 GLN A HA     1 c 
ATOM   930  H HB2    . GLN A 1 63  ? 20.971  -27.466 16.155  1    12.255 ? 1071 GLN A HB2    1 c 
ATOM   931  H HB3    . GLN A 1 63  ? 19.869  -28.752 15.654  1    12.259 ? 1071 GLN A HB3    1 c 
ATOM   932  H HG2    . GLN A 1 63  ? 21.188  -28.788 13.428  1    12.339 ? 1071 GLN A HG2    1 c 
ATOM   933  H HG3    . GLN A 1 63  ? 22.396  -27.803 14.261  1    12.329 ? 1071 GLN A HG3    1 c 
ATOM   934  H HE21   . GLN A 1 63  ? 21.113  -30.992 13.799  1    13.035 ? 1071 GLN A HE21   1 ? 
ATOM   935  H HE22   . GLN A 1 63  ? 22.318  -31.796 14.816  1    12.812 ? 1071 GLN A HE22   1 ? 
ATOM   936  N N      . SER A 1 64  ? 17.572  -27.499 15.647  1    13.109 ? 1072 SER A N      1 ? 
ATOM   937  C CA     . SER A 1 64  ? 16.355  -27.321 16.427  1    13.584 ? 1072 SER A CA     1 ? 
ATOM   938  C C      . SER A 1 64  ? 16.383  -28.232 17.66   1    12.214 ? 1072 SER A C      1 ? 
ATOM   939  O O      . SER A 1 64  ? 16.957  -29.328 17.622  1    12.688 ? 1072 SER A O      1 ? 
ATOM   940  C CB     . SER A 1 64  ? 15.141  -27.609 15.571  1    14.529 ? 1072 SER A CB     1 ? 
ATOM   941  O OG     . SER A 1 64  ? 15.05   -26.776 14.425  1    15.266 ? 1072 SER A OG     1 ? 
ATOM   942  H H      . SER A 1 64  ? 17.71   -28.431 15.214  1    12.388 ? 1072 SER A H      1 ? 
ATOM   943  H HA     . SER A 1 64  ? 16.309  -26.285 16.765  1    13.384 ? 1072 SER A HA     1 c 
ATOM   944  H HB2    . SER A 1 64  ? 15.172  -28.652 15.251  1    14.485 ? 1072 SER A HB2    1 c 
ATOM   945  H HB3    . SER A 1 64  ? 14.242  -27.477 16.178  1    14.485 ? 1072 SER A HB3    1 c 
ATOM   946  H HG     . SER A 1 64  ? 15.525  -27.248 13.726  1    15.809 ? 1072 SER A HG     1 ? 
ATOM   947  N N      . TYR A 1 65  ? 15.742  -27.784 18.745  1    10.683 ? 1073 TYR A N      1 ? 
ATOM   948  C CA     . TYR A 1 65  ? 15.422  -28.653 19.863  1    11.24  ? 1073 TYR A CA     1 ? 
ATOM   949  C C      . TYR A 1 65  ? 13.957  -29.072 19.743  1    12.126 ? 1073 TYR A C      1 ? 
ATOM   950  O O      . TYR A 1 65  ? 13.109  -28.309 19.267  1    11.778 ? 1073 TYR A O      1 ? 
ATOM   951  C CB     . TYR A 1 65  ? 15.579  -27.897 21.172  1    11.221 ? 1073 TYR A CB     1 ? 
ATOM   952  C CG     . TYR A 1 65  ? 16.951  -27.873 21.818  1    12.412 ? 1073 TYR A CG     1 ? 
ATOM   953  C CD1    . TYR A 1 65  ? 17.857  -28.93  21.712  1    12.013 ? 1073 TYR A CD1    1 ? 
ATOM   954  C CD2    . TYR A 1 65  ? 17.312  -26.788 22.591  1    12.149 ? 1073 TYR A CD2    1 ? 
ATOM   955  C CE1    . TYR A 1 65  ? 19.079  -28.897 22.381  1    13.015 ? 1073 TYR A CE1    1 ? 
ATOM   956  C CE2    . TYR A 1 65  ? 18.525  -26.736 23.243  1    12.334 ? 1073 TYR A CE2    1 ? 
ATOM   957  C CZ     . TYR A 1 65  ? 19.417  -27.775 23.14   1    11.529 ? 1073 TYR A CZ     1 ? 
ATOM   958  O OH     . TYR A 1 65  ? 20.574  -27.712 23.883  1    12.448 ? 1073 TYR A OH     1 ? 
ATOM   959  H H      . TYR A 1 65  ? 15.387  -26.805 18.749  1    11.304 ? 1073 TYR A H      1 ? 
ATOM   960  H HA     . TYR A 1 65  ? 16.066  -29.533 19.853  1    11.301 ? 1073 TYR A HA     1 c 
ATOM   961  H HB2    . TYR A 1 65  ? 15.266  -26.865 21      1    11.478 ? 1073 TYR A HB2    1 c 
ATOM   962  H HB3    . TYR A 1 65  ? 14.873  -28.321 21.889  1    11.481 ? 1073 TYR A HB3    1 c 
ATOM   963  H HD1    . TYR A 1 65  ? 17.593  -29.806 21.129  1    12.285 ? 1073 TYR A HD1    1 c 
ATOM   964  H HD2    . TYR A 1 65  ? 16.62   -25.96  22.697  1    12.239 ? 1073 TYR A HD2    1 c 
ATOM   965  H HE1    . TYR A 1 65  ? 19.769  -29.729 22.301  1    12.453 ? 1073 TYR A HE1    1 c 
ATOM   966  H HE2    . TYR A 1 65  ? 18.769  -25.877 23.86   1    12.119 ? 1073 TYR A HE2    1 c 
ATOM   967  H HH     . TYR A 1 65  ? 21.076  -28.531 23.64   1    12.39  ? 1073 TYR A HH     1 ? 
ATOM   968  N N      . GLY A 1 66  ? 13.651  -30.277 20.212  1    11.74  ? 1074 GLY A N      1 ? 
ATOM   969  C CA     . GLY A 1 66  ? 12.281  -30.646 20.473  1    12.696 ? 1074 GLY A CA     1 ? 
ATOM   970  C C      . GLY A 1 66  ? 11.918  -30.402 21.926  1    13.043 ? 1074 GLY A C      1 ? 
ATOM   971  O O      . GLY A 1 66  ? 12.74   -30.563 22.82   1    14.499 ? 1074 GLY A O      1 ? 
ATOM   972  H H      . GLY A 1 66  ? 14.418  -30.917 20.495  1    11.941 ? 1074 GLY A H      1 ? 
ATOM   973  H HA2    . GLY A 1 66  ? 11.619  -30.072 19.824  1    12.547 ? 1074 GLY A HA2    1 c 
ATOM   974  H HA3    . GLY A 1 66  ? 12.153  -31.703 20.238  1    12.602 ? 1074 GLY A HA3    1 c 
ATOM   975  N N      . VAL A 1 67  ? 10.667  -30.02  22.151  1    13.704 ? 1075 VAL A N      1 ? 
ATOM   976  C CA     . VAL A 1 67  ? 10.109  -29.877 23.487  1    14.053 ? 1075 VAL A CA     1 ? 
ATOM   977  C C      . VAL A 1 67  ? 8.81    -30.673 23.544  1    13.786 ? 1075 VAL A C      1 ? 
ATOM   978  O O      . VAL A 1 67  ? 7.968   -30.551 22.653  1    13.896 ? 1075 VAL A O      1 ? 
ATOM   979  C CB     . VAL A 1 67  ? 9.839   -28.397 23.851  1    15.273 ? 1075 VAL A CB     1 ? 
ATOM   980  C CG1    . VAL A 1 67  ? 9.197   -28.282 25.213  1    14.626 ? 1075 VAL A CG1    1 ? 
ATOM   981  C CG2    . VAL A 1 67  ? 11.106  -27.564 23.775  1    16.047 ? 1075 VAL A CG2    1 ? 
ATOM   982  H H      . VAL A 1 67  ? 10.049  -29.776 21.353  1    13.54  ? 1075 VAL A H      1 ? 
ATOM   983  H HA     . VAL A 1 67  ? 10.811  -30.295 24.209  1    14.136 ? 1075 VAL A HA     1 c 
ATOM   984  H HB     . VAL A 1 67  ? 9.134   -28.007 23.113  1    15.064 ? 1075 VAL A HB     1 c 
ATOM   985  H HG11   . VAL A 1 67  ? 8.201   -28.729 25.19   1    14.794 ? 1075 VAL A HG11   1 c 
ATOM   986  H HG12   . VAL A 1 67  ? 9.811   -28.802 25.952  1    14.799 ? 1075 VAL A HG12   1 c 
ATOM   987  H HG13   . VAL A 1 67  ? 9.113   -27.228 25.488  1    14.789 ? 1075 VAL A HG13   1 c 
ATOM   988  H HG21   . VAL A 1 67  ? 10.879  -26.529 24.038  1    15.812 ? 1075 VAL A HG21   1 c 
ATOM   989  H HG22   . VAL A 1 67  ? 11.847  -27.961 24.472  1    15.812 ? 1075 VAL A HG22   1 c 
ATOM   990  H HG23   . VAL A 1 67  ? 11.507  -27.6   22.76   1    15.764 ? 1075 VAL A HG23   1 c 
ATOM   991  N N      . ILE A 1 68  ? 8.652   -31.487 24.577  1    13.219 ? 1076 ILE A N      1 ? 
ATOM   992  C CA     . ILE A 1 68  ? 7.428   -32.227 24.824  1    14.187 ? 1076 ILE A CA     1 ? 
ATOM   993  C C      . ILE A 1 68  ? 6.675   -31.523 25.949  1    12.553 ? 1076 ILE A C      1 ? 
ATOM   994  O O      . ILE A 1 68  ? 7.088   -31.615 27.107  1    12.506 ? 1076 ILE A O      1 ? 
ATOM   995  C CB     . ILE A 1 68  ? 7.695   -33.697 25.165  1    16.263 ? 1076 ILE A CB     1 ? 
ATOM   996  C CG1    . ILE A 1 68  ? 8.366   -34.393 23.981  1    17.968 ? 1076 ILE A CG1    1 ? 
ATOM   997  C CG2    . ILE A 1 68  ? 6.413   -34.411 25.552  1    16.099 ? 1076 ILE A CG2    1 ? 
ATOM   998  C CD1    . ILE A 1 68  ? 8.976   -35.745 24.297  1    19.73  ? 1076 ILE A CD1    1 ? 
ATOM   999  H H      . ILE A 1 68  ? 9.431   -31.561 25.257  1    13.086 ? 1076 ILE A H      1 ? 
ATOM   1000 H HA     . ILE A 1 68  ? 6.818   -32.194 23.921  1    14.001 ? 1076 ILE A HA     1 c 
ATOM   1001 H HB     . ILE A 1 68  ? 8.38    -33.732 26.015  1    16.127 ? 1076 ILE A HB     1 c 
ATOM   1002 H HG12   . ILE A 1 68  ? 7.625   -34.522 23.189  1    17.941 ? 1076 ILE A HG12   1 c 
ATOM   1003 H HG13   . ILE A 1 68  ? 9.153   -33.741 23.594  1    17.914 ? 1076 ILE A HG13   1 c 
ATOM   1004 H HG21   . ILE A 1 68  ? 6.642   -35.431 25.866  1    16.174 ? 1076 ILE A HG21   1 c 
ATOM   1005 H HG22   . ILE A 1 68  ? 5.925   -33.881 26.37   1    16.217 ? 1076 ILE A HG22   1 c 
ATOM   1006 H HG23   . ILE A 1 68  ? 5.74    -34.44  24.693  1    16.111 ? 1076 ILE A HG23   1 c 
ATOM   1007 H HD11   . ILE A 1 68  ? 9.791   -35.619 25.013  1    19.213 ? 1076 ILE A HD11   1 c 
ATOM   1008 H HD12   . ILE A 1 68  ? 8.213   -36.394 24.729  1    19.308 ? 1076 ILE A HD12   1 c 
ATOM   1009 H HD13   . ILE A 1 68  ? 9.364   -36.198 23.383  1    19.186 ? 1076 ILE A HD13   1 c 
ATOM   1010 N N      . PRO A 1 69  ? 5.595   -30.802 25.656  1    11.568 ? 1077 PRO A N      1 ? 
ATOM   1011 C CA     . PRO A 1 69  ? 4.87    -30.134 26.721  1    11.86  ? 1077 PRO A CA     1 ? 
ATOM   1012 C C      . PRO A 1 69  ? 4.164   -31.157 27.601  1    13.811 ? 1077 PRO A C      1 ? 
ATOM   1013 O O      . PRO A 1 69  ? 3.949   -32.308 27.196  1    13.346 ? 1077 PRO A O      1 ? 
ATOM   1014 C CB     . PRO A 1 69  ? 3.878   -29.25  25.972  1    11.673 ? 1077 PRO A CB     1 ? 
ATOM   1015 C CG     . PRO A 1 69  ? 3.605   -30.049 24.717  1    11.885 ? 1077 PRO A CG     1 ? 
ATOM   1016 C CD     . PRO A 1 69  ? 4.926   -30.643 24.346  1    12.097 ? 1077 PRO A CD     1 ? 
ATOM   1017 H HA     . PRO A 1 69  ? 5.557   -29.529 27.315  1    12.113 ? 1077 PRO A HA     1 c 
ATOM   1018 H HB2    . PRO A 1 69  ? 2.965   -29.104 26.553  1    11.759 ? 1077 PRO A HB2    1 c 
ATOM   1019 H HB3    . PRO A 1 69  ? 4.318   -28.28  25.734  1    11.759 ? 1077 PRO A HB3    1 c 
ATOM   1020 H HG2    . PRO A 1 69  ? 2.869   -30.834 24.907  1    11.885 ? 1077 PRO A HG2    1 c 
ATOM   1021 H HG3    . PRO A 1 69  ? 3.235   -29.403 23.918  1    11.885 ? 1077 PRO A HG3    1 c 
ATOM   1022 H HD2    . PRO A 1 69  ? 4.803   -31.609 23.852  1    11.949 ? 1077 PRO A HD2    1 c 
ATOM   1023 H HD3    . PRO A 1 69  ? 5.497   -29.974 23.697  1    11.935 ? 1077 PRO A HD3    1 c 
ATOM   1024 N N      . PRO A 1 70  ? 3.791   -30.767 28.819  1    13.793 ? 1078 PRO A N      1 ? 
ATOM   1025 C CA     . PRO A 1 70  ? 3.113   -31.683 29.722  1    15.188 ? 1078 PRO A CA     1 ? 
ATOM   1026 C C      . PRO A 1 70  ? 1.716   -32.069 29.252  1    17.023 ? 1078 PRO A C      1 ? 
ATOM   1027 O O      . PRO A 1 70  ? 1.116   -31.43  28.39   1    16.503 ? 1078 PRO A O      1 ? 
ATOM   1028 C CB     . PRO A 1 70  ? 3.058   -30.93  31.052  1    14.179 ? 1078 PRO A CB     1 ? 
ATOM   1029 C CG     . PRO A 1 70  ? 3.827   -29.674 30.883  1    14.221 ? 1078 PRO A CG     1 ? 
ATOM   1030 C CD     . PRO A 1 70  ? 3.989   -29.438 29.409  1    13.335 ? 1078 PRO A CD     1 ? 
ATOM   1031 H HA     . PRO A 1 70  ? 3.717   -32.585 29.84   1    15.037 ? 1078 PRO A HA     1 c 
ATOM   1032 H HB2    . PRO A 1 70  ? 2.023   -30.709 31.323  1    14.413 ? 1078 PRO A HB2    1 c 
ATOM   1033 H HB3    . PRO A 1 70  ? 3.49    -31.536 31.851  1    14.401 ? 1078 PRO A HB3    1 c 
ATOM   1034 H HG2    . PRO A 1 70  ? 3.295   -28.837 31.341  1    14.013 ? 1078 PRO A HG2    1 c 
ATOM   1035 H HG3    . PRO A 1 70  ? 4.806   -29.761 31.359  1    14.013 ? 1078 PRO A HG3    1 c 
ATOM   1036 H HD2    . PRO A 1 70  ? 3.242   -28.735 29.036  1    13.62  ? 1078 PRO A HD2    1 c 
ATOM   1037 H HD3    . PRO A 1 70  ? 4.986   -29.057 29.181  1    13.604 ? 1078 PRO A HD3    1 c 
ATOM   1038 N N      . GLY A 1 71  ? 1.206   -33.134 29.845  1    18.353 ? 1079 GLY A N      1 ? 
ATOM   1039 C CA     . GLY A 1 71  ? -0.156  -33.575 29.639  1    18.886 ? 1079 GLY A CA     1 ? 
ATOM   1040 C C      . GLY A 1 71  ? -0.239  -34.793 28.729  1    18.455 ? 1079 GLY A C      1 ? 
ATOM   1041 O O      . GLY A 1 71  ? 0.73    -35.272 28.152  1    20.27  ? 1079 GLY A O      1 ? 
ATOM   1042 H H      . GLY A 1 71  ? 1.791   -33.586 30.573  1    19.282 ? 1079 GLY A H      1 ? 
ATOM   1043 H HA2    . GLY A 1 71  ? -0.597  -33.819 30.607  1    18.673 ? 1079 GLY A HA2    1 c 
ATOM   1044 H HA3    . GLY A 1 71  ? -0.736  -32.758 29.206  1    18.688 ? 1079 GLY A HA3    1 c 
ATOM   1045 N N      . GLU A 1 72  ? -1.464  -35.292 28.617  1    22.218 ? 1080 GLU A N      1 ? 
ATOM   1046 C CA     . GLU A 1 72  ? -1.777  -36.397 27.732  1    25.427 ? 1080 GLU A CA     1 ? 
ATOM   1047 C C      . GLU A 1 72  ? -1.959  -35.894 26.292  1    23.692 ? 1080 GLU A C      1 ? 
ATOM   1048 O O      . GLU A 1 72  ? -2.44   -34.789 26.038  1    22.549 ? 1080 GLU A O      1 ? 
ATOM   1049 C CB     . GLU A 1 72  ? -3.016  -37.012 28.401  1    31.621 ? 1080 GLU A CB     1 ? 
ATOM   1050 C CG     . GLU A 1 72  ? -3.832  -37.975 27.542  1    40.038 ? 1080 GLU A CG     1 ? 
ATOM   1051 C CD     . GLU A 1 72  ? -4.71   -38.877 28.393  1    43.31  ? 1080 GLU A CD     1 ? 
ATOM   1052 O OE1    . GLU A 1 72  ? -5.947  -38.783 28.296  1    45.415 ? 1080 GLU A OE1    1 ? 
ATOM   1053 O OE2    . GLU A 1 72  ? -4.133  -39.673 29.164  1    42.546 ? 1080 GLU A OE2    1 ? 
ATOM   1054 H H      . GLU A 1 72  ? -2.237  -34.87  29.163  1    21.69  ? 1080 GLU A H      1 ? 
ATOM   1055 H HA     . GLU A 1 72  ? -0.953  -37.112 27.761  1    25.4   ? 1080 GLU A HA     1 c 
ATOM   1056 H HB2    . GLU A 1 72  ? -2.697  -37.539 29.303  1    31.792 ? 1080 GLU A HB2    1 c 
ATOM   1057 H HB3    . GLU A 1 72  ? -3.681  -36.203 28.711  1    31.668 ? 1080 GLU A HB3    1 c 
ATOM   1058 H HG2    . GLU A 1 72  ? -4.464  -37.407 26.857  1    38.695 ? 1080 GLU A HG2    1 c 
ATOM   1059 H HG3    . GLU A 1 72  ? -3.155  -38.596 26.95   1    38.694 ? 1080 GLU A HG3    1 c 
ATOM   1060 N N      . ASN A 1 73  ? -1.564  -36.745 25.351  1    25.054 ? 1081 ASN A N      1 ? 
ATOM   1061 C CA     . ASN A 1 73  ? -1.848  -36.484 23.945  1    26.519 ? 1081 ASN A CA     1 ? 
ATOM   1062 C C      . ASN A 1 73  ? -3.37   -36.506 23.796  1    26.484 ? 1081 ASN A C      1 ? 
ATOM   1063 O O      . ASN A 1 73  ? -3.985  -37.523 24.103  1    28.623 ? 1081 ASN A O      1 ? 
ATOM   1064 C CB     . ASN A 1 73  ? -1.29   -37.569 23.018  1    28.002 ? 1081 ASN A CB     1 ? 
ATOM   1065 C CG     . ASN A 1 73  ? -1.392  -37.201 21.545  1    31.571 ? 1081 ASN A CG     1 ? 
ATOM   1066 O OD1    . ASN A 1 73  ? -2.329  -36.503 21.143  1    30.735 ? 1081 ASN A OD1    1 ? 
ATOM   1067 N ND2    . ASN A 1 73  ? -0.419  -37.594 20.73   1    35.684 ? 1081 ASN A ND2    1 ? 
ATOM   1068 H H      . ASN A 1 73  ? -1.133  -37.652 25.632  1    21.506 ? 1081 ASN A H      1 ? 
ATOM   1069 H HA     . ASN A 1 73  ? -1.437  -35.516 23.653  1    26.531 ? 1081 ASN A HA     1 c 
ATOM   1070 H HB2    . ASN A 1 73  ? -0.243  -37.745 23.267  1    28.442 ? 1081 ASN A HB2    1 c 
ATOM   1071 H HB3    . ASN A 1 73  ? -1.834  -38.499 23.189  1    28.704 ? 1081 ASN A HB3    1 c 
ATOM   1072 H HD21   . ASN A 1 73  ? -0.468  -37.368 19.74   1    34.085 ? 1081 ASN A HD21   1 ? 
ATOM   1073 H HD22   . ASN A 1 73  ? 0.412   -38.073 21.086  1    37.441 ? 1081 ASN A HD22   1 ? 
ATOM   1074 N N      . PRO A 1 74  ? -4.057  -35.421 23.376  1    29.583 ? 1082 PRO A N      1 ? 
ATOM   1075 C CA     . PRO A 1 74  ? -5.515  -35.479 23.249  1    32.77  ? 1082 PRO A CA     1 ? 
ATOM   1076 C C      . PRO A 1 74  ? -5.987  -36.554 22.255  1    37.485 ? 1082 PRO A C      1 ? 
ATOM   1077 O O      . PRO A 1 74  ? -7.1    -37.07  22.377  1    41.352 ? 1082 PRO A O      1 ? 
ATOM   1078 C CB     . PRO A 1 74  ? -5.925  -34.038 22.871  1    30.313 ? 1082 PRO A CB     1 ? 
ATOM   1079 C CG     . PRO A 1 74  ? -4.668  -33.186 23.073  1    32.722 ? 1082 PRO A CG     1 ? 
ATOM   1080 C CD     . PRO A 1 74  ? -3.488  -34.125 22.973  1    29.449 ? 1082 PRO A CD     1 ? 
ATOM   1081 H HA     . PRO A 1 74  ? -5.939  -35.706 24.23   1    32.471 ? 1082 PRO A HA     1 c 
ATOM   1082 H HB2    . PRO A 1 74  ? -6.258  -33.992 21.832  1    31.333 ? 1082 PRO A HB2    1 c 
ATOM   1083 H HB3    . PRO A 1 74  ? -6.737  -33.686 23.511  1    31.333 ? 1082 PRO A HB3    1 c 
ATOM   1084 H HG2    . PRO A 1 74  ? -4.602  -32.412 22.307  1    31.457 ? 1082 PRO A HG2    1 c 
ATOM   1085 H HG3    . PRO A 1 74  ? -4.686  -32.704 24.053  1    31.457 ? 1082 PRO A HG3    1 c 
ATOM   1086 H HD2    . PRO A 1 74  ? -3.101  -34.172 21.954  1    30.236 ? 1082 PRO A HD2    1 c 
ATOM   1087 H HD3    . PRO A 1 74  ? -2.687  -33.827 23.651  1    30.021 ? 1082 PRO A HD3    1 c 
ATOM   1088 N N      . LYS A 1 75  ? -5.132  -36.893 21.272  1    35.403 ? 1083 LYS A N      1 ? 
ATOM   1089 C CA     . LYS A 1 75  ? -5.464  -37.834 20.208  1    38.126 ? 1083 LYS A CA     1 ? 
ATOM   1090 C C      . LYS A 1 75  ? -5.008  -39.26  20.532  1    45.967 ? 1083 LYS A C      1 ? 
ATOM   1091 O O      . LYS A 1 75  ? -5.145  -40.156 19.698  1    50.332 ? 1083 LYS A O      1 ? 
ATOM   1092 C CB     . LYS A 1 75  ? -4.835  -37.359 18.889  1    38.067 ? 1083 LYS A CB     1 ? 
ATOM   1093 C CG     . LYS A 1 75  ? -5.52   -36.09  18.347  1    44.303 ? 1083 LYS A CG     1 ? 
ATOM   1094 C CD     . LYS A 1 75  ? -4.662  -35.141 17.513  1    48.746 ? 1083 LYS A CD     1 ? 
ATOM   1095 C CE     . LYS A 1 75  ? -5.239  -33.758 17.531  1    52.812 ? 1083 LYS A CE     1 ? 
ATOM   1096 N NZ     . LYS A 1 75  ? -4.493  -32.829 16.674  1    61.113 ? 1083 LYS A NZ     1 ? 
ATOM   1097 H H      . LYS A 1 75  ? -4.205  -36.431 21.251  1    32.875 ? 1083 LYS A H      1 ? 
ATOM   1098 H HA     . LYS A 1 75  ? -6.549  -37.84  20.085  1    38.871 ? 1083 LYS A HA     1 c 
ATOM   1099 H HB2    . LYS A 1 75  ? -3.776  -37.149 19.048  1    39.367 ? 1083 LYS A HB2    1 c 
ATOM   1100 H HB3    . LYS A 1 75  ? -4.916  -38.151 18.142  1    39.414 ? 1083 LYS A HB3    1 c 
ATOM   1101 H HG2    . LYS A 1 75  ? -6.375  -36.401 17.743  1    43.756 ? 1083 LYS A HG2    1 c 
ATOM   1102 H HG3    . LYS A 1 75  ? -5.919  -35.534 19.198  1    43.714 ? 1083 LYS A HG3    1 c 
ATOM   1103 H HD2    . LYS A 1 75  ? -3.648  -35.116 17.917  1    48.665 ? 1083 LYS A HD2    1 c 
ATOM   1104 H HD3    . LYS A 1 75  ? -4.618  -35.5   16.483  1    48.617 ? 1083 LYS A HD3    1 c 
ATOM   1105 H HE2    . LYS A 1 75  ? -6.275  -33.797 17.189  1    53.642 ? 1083 LYS A HE2    1 c 
ATOM   1106 H HE3    . LYS A 1 75  ? -5.238  -33.376 18.554  1    53.673 ? 1083 LYS A HE3    1 c 
ATOM   1107 H HZ1    . LYS A 1 75  ? -4.881  -31.898 16.787  1    56.403 ? 1083 LYS A HZ1    1 ? 
ATOM   1108 H HZ2    . LYS A 1 75  ? -3.515  -32.814 16.954  1    57.677 ? 1083 LYS A HZ2    1 ? 
ATOM   1109 H HZ3    . LYS A 1 75  ? -4.554  -33.091 15.683  1    58.836 ? 1083 LYS A HZ3    1 ? 
ATOM   1110 N N      . LYS A 1 76  ? -4.511  -39.499 21.751  1    47.889 ? 1084 LYS A N      1 ? 
ATOM   1111 C CA     . LYS A 1 76  ? -3.944  -40.793 22.089  1    51.808 ? 1084 LYS A CA     1 ? 
ATOM   1112 C C      . LYS A 1 76  ? -3.921  -40.897 23.609  1    57.122 ? 1084 LYS A C      1 ? 
ATOM   1113 O O      . LYS A 1 76  ? -3.133  -40.217 24.27   1    55.611 ? 1084 LYS A O      1 ? 
ATOM   1114 C CB     . LYS A 1 76  ? -2.528  -41.042 21.556  1    55.016 ? 1084 LYS A CB     1 ? 
ATOM   1115 C CG     . LYS A 1 76  ? -2.28   -40.958 20.054  1    60.441 ? 1084 LYS A CG     1 ? 
ATOM   1116 C CD     . LYS A 1 76  ? -0.829  -41.226 19.664  1    59.349 ? 1084 LYS A CD     1 ? 
ATOM   1117 C CE     . LYS A 1 76  ? -0.444  -42.623 20.033  1    67.674 ? 1084 LYS A CE     1 ? 
ATOM   1118 N NZ     . LYS A 1 76  ? 0.949   -42.922 19.694  1    77.199 ? 1084 LYS A NZ     1 ? 
ATOM   1119 H H      . LYS A 1 76  ? -4.606  -38.788 22.5    1    47.007 ? 1084 LYS A H      1 ? 
ATOM   1120 H HA     . LYS A 1 76  ? -4.603  -41.567 21.693  1    52.523 ? 1084 LYS A HA     1 c 
ATOM   1121 H HB2    . LYS A 1 76  ? -1.862  -40.325 22.041  1    55.149 ? 1084 LYS A HB2    1 c 
ATOM   1122 H HB3    . LYS A 1 76  ? -2.225  -42.035 21.89   1    55.532 ? 1084 LYS A HB3    1 c 
ATOM   1123 H HG2    . LYS A 1 76  ? -2.925  -41.682 19.552  1    58.951 ? 1084 LYS A HG2    1 c 
ATOM   1124 H HG3    . LYS A 1 76  ? -2.561  -39.961 19.708  1    58.854 ? 1084 LYS A HG3    1 c 
ATOM   1125 H HD2    . LYS A 1 76  ? -0.71   -41.091 18.586  1    61.344 ? 1084 LYS A HD2    1 c 
ATOM   1126 H HD3    . LYS A 1 76  ? -0.175  -40.521 20.18   1    61.344 ? 1084 LYS A HD3    1 c 
ATOM   1127 H HE2    . LYS A 1 76  ? -0.575  -42.771 21.106  1    67.562 ? 1084 LYS A HE2    1 c 
ATOM   1128 H HE3    . LYS A 1 76  ? -1.095  -43.329 19.512  1    67.708 ? 1084 LYS A HE3    1 c 
ATOM   1129 H HZ1    . LYS A 1 76  ? 1.123   -43.913 19.861  1    77.987 ? 1084 LYS A HZ1    1 ? 
ATOM   1130 H HZ2    . LYS A 1 76  ? 1.136   -42.702 18.714  1    78.563 ? 1084 LYS A HZ2    1 ? 
ATOM   1131 H HZ3    . LYS A 1 76  ? 1.57    -42.365 20.277  1    75.036 ? 1084 LYS A HZ3    1 ? 
ATOM   1132 N N      . PRO A 1 77  ? -4.789  -41.735 24.218  1    59.142 ? 1085 PRO A N      1 ? 
ATOM   1133 C CA     . PRO A 1 77  ? -4.909  -41.744 25.669  1    53.561 ? 1085 PRO A CA     1 ? 
ATOM   1134 C C      . PRO A 1 77  ? -3.705  -42.432 26.315  1    46.061 ? 1085 PRO A C      1 ? 
ATOM   1135 O O      . PRO A 1 77  ? -3.201  -43.439 25.814  1    41.59  ? 1085 PRO A O      1 ? 
ATOM   1136 C CB     . PRO A 1 77  ? -6.274  -42.409 25.891  1    59.398 ? 1085 PRO A CB     1 ? 
ATOM   1137 C CG     . PRO A 1 77  ? -6.402  -43.362 24.703  1    62.752 ? 1085 PRO A CG     1 ? 
ATOM   1138 C CD     . PRO A 1 77  ? -5.65   -42.731 23.552  1    61.234 ? 1085 PRO A CD     1 ? 
ATOM   1139 H HA     . PRO A 1 77  ? -4.961  -40.713 26.026  1    53.956 ? 1085 PRO A HA     1 c 
ATOM   1140 H HB2    . PRO A 1 77  ? -6.293  -42.956 26.836  1    58.786 ? 1085 PRO A HB2    1 c 
ATOM   1141 H HB3    . PRO A 1 77  ? -7.075  -41.668 25.888  1    58.786 ? 1085 PRO A HB3    1 c 
ATOM   1142 H HG2    . PRO A 1 77  ? -5.974  -44.336 24.946  1    61.685 ? 1085 PRO A HG2    1 c 
ATOM   1143 H HG3    . PRO A 1 77  ? -7.452  -43.501 24.437  1    61.685 ? 1085 PRO A HG3    1 c 
ATOM   1144 H HD2    . PRO A 1 77  ? -5.047  -43.468 23.018  1    61.082 ? 1085 PRO A HD2    1 c 
ATOM   1145 H HD3    . PRO A 1 77  ? -6.331  -42.245 22.85   1    61.082 ? 1085 PRO A HD3    1 c 
ATOM   1146 N N      . GLY A 1 78  ? -3.204  -41.821 27.391  1    41.777 ? 1086 GLY A N      1 ? 
ATOM   1147 C CA     . GLY A 1 78  ? -2.094  -42.376 28.156  1    40.26  ? 1086 GLY A CA     1 ? 
ATOM   1148 C C      . GLY A 1 78  ? -0.733  -42.093 27.514  1    38.57  ? 1086 GLY A C      1 ? 
ATOM   1149 O O      . GLY A 1 78  ? 0.302   -42.466 28.063  1    38.719 ? 1086 GLY A O      1 ? 
ATOM   1150 H H      . GLY A 1 78  ? -3.628  -40.923 27.697  1    37.66  ? 1086 GLY A H      1 ? 
ATOM   1151 H HA2    . GLY A 1 78  ? -2.113  -41.953 29.163  1    40.222 ? 1086 GLY A HA2    1 c 
ATOM   1152 H HA3    . GLY A 1 78  ? -2.232  -43.456 28.246  1    40.19  ? 1086 GLY A HA3    1 c 
ATOM   1153 N N      . ALA A 1 79  ? -0.742  -41.452 26.341  1    38.891 ? 1087 ALA A N      1 ? 
ATOM   1154 C CA     . ALA A 1 79  ? 0.482   -41.229 25.594  1    38.359 ? 1087 ALA A CA     1 ? 
ATOM   1155 C C      . ALA A 1 79  ? 0.952   -39.808 25.897  1    34.965 ? 1087 ALA A C      1 ? 
ATOM   1156 O O      . ALA A 1 79  ? 0.131   -38.944 26.207  1    32.656 ? 1087 ALA A O      1 ? 
ATOM   1157 C CB     . ALA A 1 79  ? 0.225   -41.437 24.12   1    31.26  ? 1087 ALA A CB     1 ? 
ATOM   1158 H H      . ALA A 1 79  ? -1.622  -41.072 25.946  1    35.371 ? 1087 ALA A H      1 ? 
ATOM   1159 H HA     . ALA A 1 79  ? 1.239   -41.935 25.939  1    36.427 ? 1087 ALA A HA     1 c 
ATOM   1160 H HB1    . ALA A 1 79  ? -0.542  -40.739 23.778  1    33.141 ? 1087 ALA A HB1    1 c 
ATOM   1161 H HB2    . ALA A 1 79  ? 1.145   -41.264 23.558  1    33.141 ? 1087 ALA A HB2    1 c 
ATOM   1162 H HB3    . ALA A 1 79  ? -0.116  -42.46  23.947  1    33.26  ? 1087 ALA A HB3    1 c 
ATOM   1163 N N      . PRO A 1 80  ? 2.26    -39.502 25.774  1    34.4   ? 1088 PRO A N      1 ? 
ATOM   1164 C CA     . PRO A 1 80  ? 2.695   -38.128 25.938  1    27.932 ? 1088 PRO A CA     1 ? 
ATOM   1165 C C      . PRO A 1 80  ? 2.266   -37.275 24.751  1    24.759 ? 1088 PRO A C      1 ? 
ATOM   1166 O O      . PRO A 1 80  ? 1.886   -37.754 23.683  1    25.169 ? 1088 PRO A O      1 ? 
ATOM   1167 C CB     . PRO A 1 80  ? 4.209   -38.236 26.13   1    28.902 ? 1088 PRO A CB     1 ? 
ATOM   1168 C CG     . PRO A 1 80  ? 4.525   -39.733 26.1    1    29.454 ? 1088 PRO A CG     1 ? 
ATOM   1169 C CD     . PRO A 1 80  ? 3.366   -40.402 25.409  1    30.777 ? 1088 PRO A CD     1 ? 
ATOM   1170 H HA     . PRO A 1 80  ? 2.252   -37.721 26.849  1    28.63  ? 1088 PRO A HA     1 c 
ATOM   1171 H HB2    . PRO A 1 80  ? 4.737   -37.715 25.329  1    28.824 ? 1088 PRO A HB2    1 c 
ATOM   1172 H HB3    . PRO A 1 80  ? 4.509   -37.798 27.084  1    28.889 ? 1088 PRO A HB3    1 c 
ATOM   1173 H HG2    . PRO A 1 80  ? 5.45    -39.919 25.552  1    29.62  ? 1088 PRO A HG2    1 c 
ATOM   1174 H HG3    . PRO A 1 80  ? 4.637   -40.122 27.114  1    29.619 ? 1088 PRO A HG3    1 c 
ATOM   1175 H HD2    . PRO A 1 80  ? 3.505   -40.437 24.326  1    31.266 ? 1088 PRO A HD2    1 c 
ATOM   1176 H HD3    . PRO A 1 80  ? 3.198   -41.411 25.791  1    31.327 ? 1088 PRO A HD3    1 c 
ATOM   1177 N N      . GLN A 1 81  ? 2.359   -35.971 24.956  1    21.545 ? 1089 GLN A N      1 ? 
ATOM   1178 C CA     . GLN A 1 81  ? 2.213   -35.02  23.864  1    21.805 ? 1089 GLN A CA     1 ? 
ATOM   1179 C C      . GLN A 1 81  ? 3.292   -35.234 22.804  1    19.798 ? 1089 GLN A C      1 ? 
ATOM   1180 O O      . GLN A 1 81  ? 4.393   -35.706 23.067  1    15.906 ? 1089 GLN A O      1 ? 
ATOM   1181 C CB     . GLN A 1 81  ? 2.327   -33.601 24.419  1    21.356 ? 1089 GLN A CB     1 ? 
ATOM   1182 C CG     . GLN A 1 81  ? 1.303   -33.333 25.487  1    21.161 ? 1089 GLN A CG     1 ? 
ATOM   1183 C CD     . GLN A 1 81  ? 0.062   -32.648 24.943  1    20.265 ? 1089 GLN A CD     1 ? 
ATOM   1184 O OE1    . GLN A 1 81  ? -0.376  -32.905 23.811  1    20.407 ? 1089 GLN A OE1    1 ? 
ATOM   1185 N NE2    . GLN A 1 81  ? -0.546  -31.823 25.775  1    21.098 ? 1089 GLN A NE2    1 ? 
ATOM   1186 H H      . GLN A 1 81  ? 2.541   -35.617 25.911  1    23.162 ? 1089 GLN A H      1 ? 
ATOM   1187 H HA     . GLN A 1 81  ? 1.231   -35.16  23.409  1    21.32  ? 1089 GLN A HA     1 c 
ATOM   1188 H HB2    . GLN A 1 81  ? 3.327   -33.459 24.835  1    21.407 ? 1089 GLN A HB2    1 c 
ATOM   1189 H HB3    . GLN A 1 81  ? 2.196   -32.886 23.605  1    21.396 ? 1089 GLN A HB3    1 c 
ATOM   1190 H HG2    . GLN A 1 81  ? 1.007   -34.274 25.952  1    21.003 ? 1089 GLN A HG2    1 c 
ATOM   1191 H HG3    . GLN A 1 81  ? 1.743   -32.703 26.26   1    20.915 ? 1089 GLN A HG3    1 c 
ATOM   1192 H HE21   . GLN A 1 81  ? -0.226  -31.808 26.744  1    18.915 ? 1089 GLN A HE21   1 ? 
ATOM   1193 H HE22   . GLN A 1 81  ? -1.379  -31.292 25.493  1    21.287 ? 1089 GLN A HE22   1 ? 
ATOM   1194 N N      . ASN A 1 82  ? 2.941   -34.852 21.573  1    18.992 ? 1090 ASN A N      1 ? 
ATOM   1195 C CA     . ASN A 1 82  ? 3.901   -34.832 20.481  1    19.18  ? 1090 ASN A CA     1 ? 
ATOM   1196 C C      . ASN A 1 82  ? 4.967   -33.751 20.714  1    17.252 ? 1090 ASN A C      1 ? 
ATOM   1197 O O      . ASN A 1 82  ? 4.706   -32.687 21.275  1    16.03  ? 1090 ASN A O      1 ? 
ATOM   1198 C CB     . ASN A 1 82  ? 3.202   -34.517 19.17   1    20.089 ? 1090 ASN A CB     1 ? 
ATOM   1199 C CG     . ASN A 1 82  ? 2.188   -35.581 18.79   1    22.28  ? 1090 ASN A CG     1 ? 
ATOM   1200 O OD1    . ASN A 1 82  ? 2.368   -36.773 19.038  1    26.211 ? 1090 ASN A OD1    1 ? 
ATOM   1201 N ND2    . ASN A 1 82  ? 1.078   -35.18  18.194  1    21.577 ? 1090 ASN A ND2    1 ? 
ATOM   1202 H H      . ASN A 1 82  ? 1.983   -34.483 21.416  1    17.666 ? 1090 ASN A H      1 ? 
ATOM   1203 H HA     . ASN A 1 82  ? 4.374   -35.812 20.397  1    18.986 ? 1090 ASN A HA     1 c 
ATOM   1204 H HB2    . ASN A 1 82  ? 2.694   -33.554 19.257  1    20.338 ? 1090 ASN A HB2    1 c 
ATOM   1205 H HB3    . ASN A 1 82  ? 3.948   -34.435 18.377  1    20.341 ? 1090 ASN A HB3    1 c 
ATOM   1206 H HD21   . ASN A 1 82  ? 0.405   -35.856 17.868  1    21.5   ? 1090 ASN A HD21   1 ? 
ATOM   1207 H HD22   . ASN A 1 82  ? 0.956   -34.176 18.101  1    19.691 ? 1090 ASN A HD22   1 ? 
ATOM   1208 N N      . VAL A 1 83  ? 6.167   -34.03  20.226  1    16.733 ? 1091 VAL A N      1 ? 
ATOM   1209 C CA     . VAL A 1 83  ? 7.237   -33.051 20.173  1    16.465 ? 1091 VAL A CA     1 ? 
ATOM   1210 C C      . VAL A 1 83  ? 6.825   -31.841 19.35   1    15.864 ? 1091 VAL A C      1 ? 
ATOM   1211 O O      . VAL A 1 83  ? 6.247   -31.976 18.27   1    16.869 ? 1091 VAL A O      1 ? 
ATOM   1212 C CB     . VAL A 1 83  ? 8.482   -33.699 19.539  1    15.869 ? 1091 VAL A CB     1 ? 
ATOM   1213 C CG1    . VAL A 1 83  ? 9.544   -32.65  19.209  1    15.487 ? 1091 VAL A CG1    1 ? 
ATOM   1214 C CG2    . VAL A 1 83  ? 9.055   -34.793 20.418  1    14.672 ? 1091 VAL A CG2    1 ? 
ATOM   1215 H H      . VAL A 1 83  ? 6.3     -34.951 19.779  1    16.673 ? 1091 VAL A H      1 ? 
ATOM   1216 H HA     . VAL A 1 83  ? 7.477   -32.73  21.189  1    16.301 ? 1091 VAL A HA     1 c 
ATOM   1217 H HB     . VAL A 1 83  ? 8.163   -34.158 18.6    1    15.679 ? 1091 VAL A HB     1 c 
ATOM   1218 H HG11   . VAL A 1 83  ? 9.737   -32.037 20.092  1    15.597 ? 1091 VAL A HG11   1 c 
ATOM   1219 H HG12   . VAL A 1 83  ? 10.467  -33.149 18.906  1    15.597 ? 1091 VAL A HG12   1 c 
ATOM   1220 H HG13   . VAL A 1 83  ? 9.193   -32.013 18.395  1    15.615 ? 1091 VAL A HG13   1 c 
ATOM   1221 H HG21   . VAL A 1 83  ? 9.93    -35.23  19.932  1    15.009 ? 1091 VAL A HG21   1 c 
ATOM   1222 H HG22   . VAL A 1 83  ? 9.348   -34.371 21.381  1    15.019 ? 1091 VAL A HG22   1 c 
ATOM   1223 H HG23   . VAL A 1 83  ? 8.302   -35.568 20.575  1    15.038 ? 1091 VAL A HG23   1 c 
ATOM   1224 N N      . ARG A 1 84  ? 7.156   -30.646 19.838  1    14.666 ? 1092 ARG A N      1 ? 
ATOM   1225 C CA     . ARG A 1 84  ? 7.19    -29.445 19.016  1    14.427 ? 1092 ARG A CA     1 ? 
ATOM   1226 C C      . ARG A 1 84  ? 8.64    -29.022 18.838  1    13.826 ? 1092 ARG A C      1 ? 
ATOM   1227 O O      . ARG A 1 84  ? 9.412   -29.009 19.796  1    12.146 ? 1092 ARG A O      1 ? 
ATOM   1228 C CB     . ARG A 1 84  ? 6.426   -28.295 19.677  1    16.044 ? 1092 ARG A CB     1 ? 
ATOM   1229 C CG     . ARG A 1 84  ? 4.914   -28.335 19.527  1    16.65  ? 1092 ARG A CG     1 ? 
ATOM   1230 C CD     . ARG A 1 84  ? 4.255   -29.427 20.338  1    16.53  ? 1092 ARG A CD     1 ? 
ATOM   1231 N NE     . ARG A 1 84  ? 2.843   -29.117 20.515  1    17.412 ? 1092 ARG A NE     1 ? 
ATOM   1232 C CZ     . ARG A 1 84  ? 1.919   -29.986 20.893  1    19.4   ? 1092 ARG A CZ     1 ? 
ATOM   1233 N NH1    . ARG A 1 84  ? 2.21    -31.241 21.165  1    19.585 ? 1092 ARG A NH1    1 ? 
ATOM   1234 N NH2    . ARG A 1 84  ? 0.645   -29.635 20.921  1    18.467 ? 1092 ARG A NH2    1 ? 
ATOM   1235 H H      . ARG A 1 84  ? 7.462   -30.542 20.821  1    16.536 ? 1092 ARG A H      1 ? 
ATOM   1236 H HA     . ARG A 1 84  ? 6.756   -29.669 18.04   1    14.653 ? 1092 ARG A HA     1 c 
ATOM   1237 H HB2    . ARG A 1 84  ? 6.667   -28.291 20.742  1    15.802 ? 1092 ARG A HB2    1 c 
ATOM   1238 H HB3    . ARG A 1 84  ? 6.79    -27.356 19.256  1    15.792 ? 1092 ARG A HB3    1 c 
ATOM   1239 H HG2    . ARG A 1 84  ? 4.502   -27.371 19.833  1    16.472 ? 1092 ARG A HG2    1 c 
ATOM   1240 H HG3    . ARG A 1 84  ? 4.666   -28.479 18.473  1    16.486 ? 1092 ARG A HG3    1 c 
ATOM   1241 H HD2    . ARG A 1 84  ? 4.356   -30.385 19.824  1    16.752 ? 1092 ARG A HD2    1 c 
ATOM   1242 H HD3    . ARG A 1 84  ? 4.735   -29.507 21.315  1    16.752 ? 1092 ARG A HD3    1 c 
ATOM   1243 H HE     . ARG A 1 84  ? 2.536   -28.105 20.377  1    14.47  ? 1092 ARG A HE     1 ? 
ATOM   1244 H HH11   . ARG A 1 84  ? 3.155   -31.54  21.32   1    20.663 ? 1092 ARG A HH11   1 ? 
ATOM   1245 H HH12   . ARG A 1 84  ? 1.441   -31.889 21.239  1    19.922 ? 1092 ARG A HH12   1 ? 
ATOM   1246 H HH21   . ARG A 1 84  ? 0.315   -28.716 20.66   1    18.204 ? 1092 ARG A HH21   1 ? 
ATOM   1247 H HH22   . ARG A 1 84  ? -0.017  -30.335 21.207  1    18.023 ? 1092 ARG A HH22   1 ? 
ATOM   1248 N N      . LEU A 1 85  ? 8.998   -28.668 17.608  1    14.779 ? 1093 LEU A N      1 ? 
ATOM   1249 C CA     . LEU A 1 85  ? 10.355  -28.248 17.28   1    14.719 ? 1093 LEU A CA     1 ? 
ATOM   1250 C C      . LEU A 1 85  ? 10.503  -26.736 17.371  1    13.025 ? 1093 LEU A C      1 ? 
ATOM   1251 O O      . LEU A 1 85  ? 9.617   -25.988 16.971  1    13.405 ? 1093 LEU A O      1 ? 
ATOM   1252 C CB     . LEU A 1 85  ? 10.725  -28.724 15.875  1    15.813 ? 1093 LEU A CB     1 ? 
ATOM   1253 C CG     . LEU A 1 85  ? 10.859  -30.24  15.717  1    17.578 ? 1093 LEU A CG     1 ? 
ATOM   1254 C CD1    . LEU A 1 85  ? 11.026  -30.624 14.266  1    19.044 ? 1093 LEU A CD1    1 ? 
ATOM   1255 C CD2    . LEU A 1 85  ? 12.034  -30.776 16.503  1    19.43  ? 1093 LEU A CD2    1 ? 
ATOM   1256 H H      . LEU A 1 85  ? 8.275   -28.722 16.873  1    14.653 ? 1093 LEU A H      1 ? 
ATOM   1257 H HA     . LEU A 1 85  ? 11.035  -28.704 17.999  1    14.598 ? 1093 LEU A HA     1 c 
ATOM   1258 H HB2    . LEU A 1 85  ? 9.96    -28.369 15.181  1    15.93  ? 1093 LEU A HB2    1 c 
ATOM   1259 H HB3    . LEU A 1 85  ? 11.675  -28.262 15.596  1    15.93  ? 1093 LEU A HB3    1 c 
ATOM   1260 H HG     . LEU A 1 85  ? 9.948   -30.709 16.096  1    17.821 ? 1093 LEU A HG     1 c 
ATOM   1261 H HD11   . LEU A 1 85  ? 11.923  -30.149 13.863  1    18.601 ? 1093 LEU A HD11   1 c 
ATOM   1262 H HD12   . LEU A 1 85  ? 11.122  -31.709 14.183  1    18.601 ? 1093 LEU A HD12   1 c 
ATOM   1263 H HD13   . LEU A 1 85  ? 10.154  -30.293 13.698  1    18.537 ? 1093 LEU A HD13   1 c 
ATOM   1264 H HD21   . LEU A 1 85  ? 11.883  -30.582 17.567  1    18.827 ? 1093 LEU A HD21   1 c 
ATOM   1265 H HD22   . LEU A 1 85  ? 12.122  -31.852 16.34   1    18.86  ? 1093 LEU A HD22   1 c 
ATOM   1266 H HD23   . LEU A 1 85  ? 12.951  -30.283 16.172  1    18.789 ? 1093 LEU A HD23   1 c 
ATOM   1267 N N      . TYR A 1 86  ? 11.654  -26.289 17.865  1    13.407 ? 1094 TYR A N      1 ? 
ATOM   1268 C CA     . TYR A 1 86  ? 11.973  -24.867 17.943  1    12.522 ? 1094 TYR A CA     1 ? 
ATOM   1269 C C      . TYR A 1 86  ? 13.402  -24.648 17.468  1    12.575 ? 1094 TYR A C      1 ? 
ATOM   1270 O O      . TYR A 1 86  ? 14.335  -25.293 17.955  1    10.476 ? 1094 TYR A O      1 ? 
ATOM   1271 C CB     . TYR A 1 86  ? 11.793  -24.323 19.37   1    11.822 ? 1094 TYR A CB     1 ? 
ATOM   1272 C CG     . TYR A 1 86  ? 10.34   -24.351 19.756  1    12.552 ? 1094 TYR A CG     1 ? 
ATOM   1273 C CD1    . TYR A 1 86  ? 9.478   -23.349 19.329  1    12.723 ? 1094 TYR A CD1    1 ? 
ATOM   1274 C CD2    . TYR A 1 86  ? 9.802   -25.424 20.442  1    11.708 ? 1094 TYR A CD2    1 ? 
ATOM   1275 C CE1    . TYR A 1 86  ? 8.119   -23.405 19.588  1    12.988 ? 1094 TYR A CE1    1 ? 
ATOM   1276 C CE2    . TYR A 1 86  ? 8.45    -25.494 20.727  1    11.774 ? 1094 TYR A CE2    1 ? 
ATOM   1277 C CZ     . TYR A 1 86  ? 7.607   -24.484 20.293  1    12.733 ? 1094 TYR A CZ     1 ? 
ATOM   1278 O OH     . TYR A 1 86  ? 6.261   -24.559 20.563  1    12.564 ? 1094 TYR A OH     1 ? 
ATOM   1279 H H      . TYR A 1 86  ? 12.291  -26.974 18.303  1    13.044 ? 1094 TYR A H      1 ? 
ATOM   1280 H HA     . TYR A 1 86  ? 11.3    -24.323 17.278  1    12.571 ? 1094 TYR A HA     1 c 
ATOM   1281 H HB2    . TYR A 1 86  ? 12.367  -24.939 20.064  1    12.129 ? 1094 TYR A HB2    1 c 
ATOM   1282 H HB3    . TYR A 1 86  ? 12.162  -23.296 19.411  1    12.129 ? 1094 TYR A HB3    1 c 
ATOM   1283 H HD1    . TYR A 1 86  ? 9.873   -22.516 18.756  1    12.727 ? 1094 TYR A HD1    1 c 
ATOM   1284 H HD2    . TYR A 1 86  ? 10.454  -26.23  20.764  1    11.917 ? 1094 TYR A HD2    1 c 
ATOM   1285 H HE1    . TYR A 1 86  ? 7.463   -22.607 19.256  1    12.856 ? 1094 TYR A HE1    1 c 
ATOM   1286 H HE2    . TYR A 1 86  ? 8.05    -26.341 21.275  1    11.977 ? 1094 TYR A HE2    1 c 
ATOM   1287 H HH     . TYR A 1 86  ? 5.781   -23.952 20.021  1    13.369 ? 1094 TYR A HH     1 ? 
ATOM   1288 N N      . SER A 1 87  ? 13.565  -23.73  16.525  1    12.519 ? 1095 SER A N      1 ? 
ATOM   1289 C CA     . SER A 1 87  ? 14.878  -23.338 16.048  1    13.078 ? 1095 SER A CA     1 ? 
ATOM   1290 C C      . SER A 1 87  ? 15.71   -22.803 17.19   1    13.029 ? 1095 SER A C      1 ? 
ATOM   1291 O O      . SER A 1 87  ? 15.291  -21.892 17.893  1    16.107 ? 1095 SER A O      1 ? 
ATOM   1292 C CB     . SER A 1 87  ? 14.778  -22.241 15.005  1    13.896 ? 1095 SER A CB     1 ? 
ATOM   1293 O OG     . SER A 1 87  ? 13.904  -22.622 13.942  1    15.561 ? 1095 SER A OG     1 ? 
ATOM   1294 H H      . SER A 1 87  ? 12.728  -23.29  16.106  0.15 12.52  ? 1095 SER A H      1 ? 
ATOM   1295 H HA     . SER A 1 87  ? 15.377  -24.207 15.615  1    13.102 ? 1095 SER A HA     1 c 
ATOM   1296 H HB2    . SER A 1 87  ? 14.402  -21.329 15.474  1    14.08  ? 1095 SER A HB2    1 c 
ATOM   1297 H HB3    . SER A 1 87  ? 15.771  -22.033 14.602  1    14.08  ? 1095 SER A HB3    1 c 
ATOM   1298 H HG     . SER A 1 87  ? 14.368  -23.179 13.311  0.69 14.831 ? 1095 SER A HG     1 ? 
ATOM   1299 N N      . ILE A 1 88  ? 16.918  -23.324 17.355  1    13.208 ? 1096 ILE A N      1 ? 
ATOM   1300 C CA     . ILE A 1 88  ? 17.749  -22.812 18.426  1    12.661 ? 1096 ILE A CA     1 ? 
ATOM   1301 C C      . ILE A 1 88  ? 18.245  -21.416 18.042  1    12.85  ? 1096 ILE A C      1 ? 
ATOM   1302 O O      . ILE A 1 88  ? 18.726  -21.186 16.915  1    13.288 ? 1096 ILE A O      1 ? 
ATOM   1303 C CB     . ILE A 1 88  ? 18.883  -23.8   18.719  1    13.736 ? 1096 ILE A CB     1 ? 
ATOM   1304 C CG1    . ILE A 1 88  ? 18.278  -25.13  19.215  1    13.358 ? 1096 ILE A CG1    1 ? 
ATOM   1305 C CG2    . ILE A 1 88  ? 19.838  -23.224 19.752  1    13.073 ? 1096 ILE A CG2    1 ? 
ATOM   1306 C CD1    . ILE A 1 88  ? 19.221  -26.305 19.187  1    12.953 ? 1096 ILE A CD1    1 ? 
ATOM   1307 H H      . ILE A 1 88  ? 17.259  -24.099 16.75   1    12.796 ? 1096 ILE A H      1 ? 
ATOM   1308 H HA     . ILE A 1 88  ? 17.134  -22.725 19.324  1    12.988 ? 1096 ILE A HA     1 c 
ATOM   1309 H HB     . ILE A 1 88  ? 19.433  -23.988 17.794  1    13.351 ? 1096 ILE A HB     1 c 
ATOM   1310 H HG12   . ILE A 1 88  ? 17.928  -24.991 20.24   1    13.347 ? 1096 ILE A HG12   1 c 
ATOM   1311 H HG13   . ILE A 1 88  ? 17.409  -25.37  18.599  1    13.346 ? 1096 ILE A HG13   1 c 
ATOM   1312 H HG21   . ILE A 1 88  ? 20.475  -24.019 20.14   1    13.243 ? 1096 ILE A HG21   1 c 
ATOM   1313 H HG22   . ILE A 1 88  ? 20.46   -22.454 19.291  1    13.235 ? 1096 ILE A HG22   1 c 
ATOM   1314 H HG23   . ILE A 1 88  ? 19.267  -22.788 20.575  1    13.232 ? 1096 ILE A HG23   1 c 
ATOM   1315 H HD11   . ILE A 1 88  ? 20.067  -26.11  19.848  1    13.068 ? 1096 ILE A HD11   1 c 
ATOM   1316 H HD12   . ILE A 1 88  ? 18.697  -27.202 19.524  1    13.069 ? 1096 ILE A HD12   1 c 
ATOM   1317 H HD13   . ILE A 1 88  ? 19.584  -26.46  18.168  1    13.083 ? 1096 ILE A HD13   1 c 
ATOM   1318 N N      . ALA A 1 89  ? 18.1    -20.472 18.977  1    11.328 ? 1097 ALA A N      1 ? 
ATOM   1319 C CA     . ALA A 1 89  ? 18.42   -19.063 18.74   1    11.806 ? 1097 ALA A CA     1 ? 
ATOM   1320 C C      . ALA A 1 89  ? 19.772  -18.665 19.318  1    12.087 ? 1097 ALA A C      1 ? 
ATOM   1321 O O      . ALA A 1 89  ? 20.153  -17.485 19.251  1    10.662 ? 1097 ALA A O      1 ? 
ATOM   1322 C CB     . ALA A 1 89  ? 17.34   -18.169 19.349  1    12.395 ? 1097 ALA A CB     1 ? 
ATOM   1323 H H      . ALA A 1 89  ? 17.629  -20.724 19.871  1    11.651 ? 1097 ALA A H      1 ? 
ATOM   1324 H HA     . ALA A 1 89  ? 18.45   -18.898 17.664  1    11.864 ? 1097 ALA A HA     1 c 
ATOM   1325 H HB1    . ALA A 1 89  ? 17.583  -17.121 19.164  1    12.213 ? 1097 ALA A HB1    1 c 
ATOM   1326 H HB2    . ALA A 1 89  ? 16.374  -18.401 18.896  1    12.22  ? 1097 ALA A HB2    1 c 
ATOM   1327 H HB3    . ALA A 1 89  ? 17.284  -18.342 20.426  1    12.2   ? 1097 ALA A HB3    1 c 
ATOM   1328 N N      . SER A 1 90  ? 20.5    -19.627 19.878  1    11.368 ? 1098 SER A N      1 ? 
ATOM   1329 C CA     . SER A 1 90  ? 21.793  -19.415 20.497  1    11.477 ? 1098 SER A CA     1 ? 
ATOM   1330 C C      . SER A 1 90  ? 22.894  -20.104 19.69   1    11.81  ? 1098 SER A C      1 ? 
ATOM   1331 O O      . SER A 1 90  ? 22.649  -20.981 18.869  1    12.437 ? 1098 SER A O      1 ? 
ATOM   1332 C CB     . SER A 1 90  ? 21.762  -19.993 21.919  1    11.15  ? 1098 SER A CB     1 ? 
ATOM   1333 O OG     . SER A 1 90  ? 21.118  -21.264 21.917  1    11.405 ? 1098 SER A OG     1 ? 
ATOM   1334 H H      . SER A 1 90  ? 20.036  -20.542 20.021  1    11.973 ? 1098 SER A H      1 ? 
ATOM   1335 H HA     . SER A 1 90  ? 22      -18.344 20.546  1    11.451 ? 1098 SER A HA     1 c 
ATOM   1336 H HB2    . SER A 1 90  ? 22.782  -20.101 22.288  1    11.293 ? 1098 SER A HB2    1 c 
ATOM   1337 H HB3    . SER A 1 90  ? 21.224  -19.31  22.579  1    11.281 ? 1098 SER A HB3    1 c 
ATOM   1338 H HG     . SER A 1 90  ? 21.696  -22.033 21.787  1    11.289 ? 1098 SER A HG     1 ? 
ATOM   1339 N N      . THR A 1 91  ? 24.131  -19.708 19.973  1    12.093 ? 1099 THR A N      1 ? 
ATOM   1340 C CA     . THR A 1 91  ? 25.262  -20.473 19.468  1    10.809 ? 1099 THR A CA     1 ? 
ATOM   1341 C C      . THR A 1 91  ? 25.419  -21.737 20.299  1    11.365 ? 1099 THR A C      1 ? 
ATOM   1342 O O      . THR A 1 91  ? 24.814  -21.893 21.36   1    10.701 ? 1099 THR A O      1 ? 
ATOM   1343 C CB     . THR A 1 91  ? 26.567  -19.685 19.619  1    10.458 ? 1099 THR A CB     1 ? 
ATOM   1344 O OG1    . THR A 1 91  ? 26.928  -19.692 21.011  1    9.712  ? 1099 THR A OG1    1 ? 
ATOM   1345 C CG2    . THR A 1 91  ? 26.438  -18.273 19.078  1    10.358 ? 1099 THR A CG2    1 ? 
ATOM   1346 H H      . THR A 1 91  ? 24.298  -18.95  20.671  1    10.804 ? 1099 THR A H      1 ? 
ATOM   1347 H HA     . THR A 1 91  ? 25.099  -20.728 18.421  1    11.087 ? 1099 THR A HA     1 c 
ATOM   1348 H HB     . THR A 1 91  ? 27.348  -20.193 19.051  1    10.381 ? 1099 THR A HB     1 c 
ATOM   1349 H HG1    . THR A 1 91  ? 27.534  -18.973 21.145  1    10.553 ? 1099 THR A HG1    1 ? 
ATOM   1350 H HG21   . THR A 1 91  ? 27.416  -17.791 19.072  1    10.408 ? 1099 THR A HG21   1 c 
ATOM   1351 H HG22   . THR A 1 91  ? 26.046  -18.31  18.061  1    10.408 ? 1099 THR A HG22   1 c 
ATOM   1352 H HG23   . THR A 1 91  ? 25.754  -17.701 19.709  1    10.415 ? 1099 THR A HG23   1 c 
ATOM   1353 N N      . ARG A 1 92  ? 26.323  -22.611 19.857  1    12.861 ? 1100 ARG A N      1 ? 
ATOM   1354 C CA     . ARG A 1 92  ? 26.628  -23.824 20.61   1    12.86  ? 1100 ARG A CA     1 ? 
ATOM   1355 C C      . ARG A 1 92  ? 27.124  -23.523 22.023  1    12.444 ? 1100 ARG A C      1 ? 
ATOM   1356 O O      . ARG A 1 92  ? 27.023  -24.386 22.892  1    13.506 ? 1100 ARG A O      1 ? 
ATOM   1357 C CB     . ARG A 1 92  ? 27.653  -24.678 19.863  1    13.666 ? 1100 ARG A CB     1 ? 
ATOM   1358 C CG     . ARG A 1 92  ? 29.051  -24.09  19.807  1    13.871 ? 1100 ARG A CG     1 ? 
ATOM   1359 C CD     . ARG A 1 92  ? 29.954  -24.942 18.928  1    13.256 ? 1100 ARG A CD     1 ? 
ATOM   1360 N NE     . ARG A 1 92  ? 29.539  -24.848 17.534  1    14.501 ? 1100 ARG A NE     1 ? 
ATOM   1361 C CZ     . ARG A 1 92  ? 29.995  -25.64  16.558  1    16.321 ? 1100 ARG A CZ     1 ? 
ATOM   1362 N NH1    . ARG A 1 92  ? 30.843  -26.621 16.813  1    16.195 ? 1100 ARG A NH1    1 ? 
ATOM   1363 N NH2    . ARG A 1 92  ? 29.6    -25.418 15.312  1    15.854 ? 1100 ARG A NH2    1 ? 
ATOM   1364 H H      . ARG A 1 92  ? 26.843  -22.416 18.982  1    12.464 ? 1100 ARG A H      1 ? 
ATOM   1365 H HA     . ARG A 1 92  ? 25.707  -24.405 20.692  1    12.923 ? 1100 ARG A HA     1 c 
ATOM   1366 H HB2    . ARG A 1 92  ? 27.705  -25.655 20.347  1    13.523 ? 1100 ARG A HB2    1 c 
ATOM   1367 H HB3    . ARG A 1 92  ? 27.298  -24.833 18.843  1    13.534 ? 1100 ARG A HB3    1 c 
ATOM   1368 H HG2    . ARG A 1 92  ? 29.006  -23.077 19.401  1    13.689 ? 1100 ARG A HG2    1 c 
ATOM   1369 H HG3    . ARG A 1 92  ? 29.471  -24.043 20.813  1    13.683 ? 1100 ARG A HG3    1 c 
ATOM   1370 H HD2    . ARG A 1 92  ? 30.988  -24.603 19.023  1    13.667 ? 1100 ARG A HD2    1 c 
ATOM   1371 H HD3    . ARG A 1 92  ? 29.905  -25.984 19.252  1    13.686 ? 1100 ARG A HD3    1 c 
ATOM   1372 H HE     . ARG A 1 92  ? 29.044  -24.027 17.246  1    15.561 ? 1100 ARG A HE     1 ? 
ATOM   1373 H HH11   . ARG A 1 92  ? 31.177  -26.806 17.743  1    16.96  ? 1100 ARG A HH11   1 ? 
ATOM   1374 H HH12   . ARG A 1 92  ? 31.059  -27.221 16.055  1    18.376 ? 1100 ARG A HH12   1 ? 
ATOM   1375 H HH21   . ARG A 1 92  ? 29.071  -24.6   15.044  1    16.876 ? 1100 ARG A HH21   1 ? 
ATOM   1376 H HH22   . ARG A 1 92  ? 29.877  -26.084 14.622  1    17.211 ? 1100 ARG A HH22   1 ? 
ATOM   1377 N N      . TYR A 1 93  ? 27.699  -22.338 22.263  1    12.601 ? 1101 TYR A N      1 ? 
ATOM   1378 C CA     . TYR A 1 93  ? 28.144  -21.949 23.598  1    11.74  ? 1101 TYR A CA     1 ? 
ATOM   1379 C C      . TYR A 1 93  ? 27.007  -21.391 24.439  1    11.993 ? 1101 TYR A C      1 ? 
ATOM   1380 O O      . TYR A 1 93  ? 27.085  -21.446 25.672  1    11.166 ? 1101 TYR A O      1 ? 
ATOM   1381 C CB     . TYR A 1 93  ? 29.314  -20.953 23.509  1    11.998 ? 1101 TYR A CB     1 ? 
ATOM   1382 C CG     . TYR A 1 93  ? 30.466  -21.582 22.765  1    12.79  ? 1101 TYR A CG     1 ? 
ATOM   1383 C CD1    . TYR A 1 93  ? 31.292  -22.486 23.413  1    12.78  ? 1101 TYR A CD1    1 ? 
ATOM   1384 C CD2    . TYR A 1 93  ? 30.677  -21.329 21.409  1    13.089 ? 1101 TYR A CD2    1 ? 
ATOM   1385 C CE1    . TYR A 1 93  ? 32.306  -23.127 22.747  1    14.505 ? 1101 TYR A CE1    1 ? 
ATOM   1386 C CE2    . TYR A 1 93  ? 31.69   -21.978 20.727  1    13.862 ? 1101 TYR A CE2    1 ? 
ATOM   1387 C CZ     . TYR A 1 93  ? 32.497  -22.872 21.396  1    14.709 ? 1101 TYR A CZ     1 ? 
ATOM   1388 O OH     . TYR A 1 93  ? 33.477  -23.547 20.745  1    17.181 ? 1101 TYR A OH     1 ? 
ATOM   1389 H H      . TYR A 1 93  ? 27.847  -21.668 21.489  1    12.607 ? 1101 TYR A H      1 ? 
ATOM   1390 H HA     . TYR A 1 93  ? 28.515  -22.847 24.097  1    11.998 ? 1101 TYR A HA     1 c 
ATOM   1391 H HB2    . TYR A 1 93  ? 28.983  -20.056 22.98   1    12.111 ? 1101 TYR A HB2    1 c 
ATOM   1392 H HB3    . TYR A 1 93  ? 29.633  -20.681 24.517  1    12.111 ? 1101 TYR A HB3    1 c 
ATOM   1393 H HD1    . TYR A 1 93  ? 31.125  -22.704 24.462  1    13.187 ? 1101 TYR A HD1    1 c 
ATOM   1394 H HD2    . TYR A 1 93  ? 30.024  -20.644 20.879  1    13.194 ? 1101 TYR A HD2    1 c 
ATOM   1395 H HE1    . TYR A 1 93  ? 32.937  -23.839 23.264  1    14.15  ? 1101 TYR A HE1    1 c 
ATOM   1396 H HE2    . TYR A 1 93  ? 31.848  -21.787 19.67   1    13.873 ? 1101 TYR A HE2    1 c 
ATOM   1397 H HH     . TYR A 1 93  ? 33.386  -23.394 19.767  1    16.402 ? 1101 TYR A HH     1 ? 
ATOM   1398 N N      . GLY A 1 94  ? 25.976  -20.858 23.796  1    13.707 ? 1102 GLY A N      1 ? 
ATOM   1399 C CA     . GLY A 1 94  ? 24.818  -20.35  24.493  1    12.69  ? 1102 GLY A CA     1 ? 
ATOM   1400 C C      . GLY A 1 94  ? 25.046  -18.977 25.092  1    13.552 ? 1102 GLY A C      1 ? 
ATOM   1401 O O      . GLY A 1 94  ? 26.131  -18.416 25.061  1    14.514 ? 1102 GLY A O      1 ? 
ATOM   1402 H H      . GLY A 1 94  ? 25.968  -20.888 22.764  1    12.316 ? 1102 GLY A H      1 ? 
ATOM   1403 H HA2    . GLY A 1 94  ? 23.981  -20.304 23.797  1    13.09  ? 1102 GLY A HA2    1 c 
ATOM   1404 H HA3    . GLY A 1 94  ? 24.551  -21.048 25.287  1    13.136 ? 1102 GLY A HA3    1 c 
ATOM   1405 N N      . ASP A 1 95  ? 23.968  -18.435 25.639  1    12.797 ? 1103 ASP A N      1 ? 
ATOM   1406 C CA     . ASP A 1 95  ? 23.935  -17.051 26.074  1    13.394 ? 1103 ASP A CA     1 ? 
ATOM   1407 C C      . ASP A 1 95  ? 24.79   -16.815 27.327  1    14.063 ? 1103 ASP A C      1 ? 
ATOM   1408 O O      . ASP A 1 95  ? 25.073  -15.647 27.635  1    13.994 ? 1103 ASP A O      1 ? 
ATOM   1409 C CB     . ASP A 1 95  ? 22.505  -16.614 26.35   1    13.309 ? 1103 ASP A CB     1 ? 
ATOM   1410 C CG     . ASP A 1 95  ? 21.626  -16.583 25.103  1    12.759 ? 1103 ASP A CG     1 ? 
ATOM   1411 O OD1    . ASP A 1 95  ? 22.141  -16.694 23.953  1    15.123 ? 1103 ASP A OD1    1 ? 
ATOM   1412 O OD2    . ASP A 1 95  ? 20.398  -16.443 25.298  1    14.02  ? 1103 ASP A OD2    1 ? 
ATOM   1413 H H      . ASP A 1 95  ? 23.073  -18.957 25.585  1    12.705 ? 1103 ASP A H      1 ? 
ATOM   1414 H HA     . ASP A 1 95  ? 24.328  -16.431 25.265  1    13.387 ? 1103 ASP A HA     1 c 
ATOM   1415 H HB2    . ASP A 1 95  ? 22.056  -17.303 27.069  1    13.221 ? 1103 ASP A HB2    1 c 
ATOM   1416 H HB3    . ASP A 1 95  ? 22.516  -15.619 26.798  1    13.285 ? 1103 ASP A HB3    1 c 
ATOM   1417 N N      . ASN A 1 96  ? 25.236  -17.882 28.009  1    14.035 ? 1104 ASN A N      1 ? 
ATOM   1418 C CA     . ASN A 1 96  ? 26.128  -17.743 29.152  1    14.714 ? 1104 ASN A CA     1 ? 
ATOM   1419 C C      . ASN A 1 96  ? 27.567  -18.097 28.749  1    14.562 ? 1104 ASN A C      1 ? 
ATOM   1420 O O      . ASN A 1 96  ? 28.446  -18.114 29.613  1    14.588 ? 1104 ASN A O      1 ? 
ATOM   1421 C CB     . ASN A 1 96  ? 25.596  -18.523 30.344  1    15.891 ? 1104 ASN A CB     1 ? 
ATOM   1422 C CG     . ASN A 1 96  ? 26.116  -18.102 31.706  1    17.899 ? 1104 ASN A CG     1 ? 
ATOM   1423 O OD1    . ASN A 1 96  ? 26.261  -16.91  31.993  1    17.41  ? 1104 ASN A OD1    1 ? 
ATOM   1424 N ND2    . ASN A 1 96  ? 26.353  -19.075 32.593  1    20.277 ? 1104 ASN A ND2    1 ? 
ATOM   1425 H H      . ASN A 1 96  ? 24.957  -18.831 27.715  1    14.37  ? 1104 ASN A H      1 ? 
ATOM   1426 H HA     . ASN A 1 96  ? 26.125  -16.691 29.443  1    14.838 ? 1104 ASN A HA     1 c 
ATOM   1427 H HB2    . ASN A 1 96  ? 24.509  -18.438 30.347  1    16.214 ? 1104 ASN A HB2    1 c 
ATOM   1428 H HB3    . ASN A 1 96  ? 25.838  -19.578 30.198  1    16.074 ? 1104 ASN A HB3    1 c 
ATOM   1429 H HD21   . ASN A 1 96  ? 26.458  -18.861 33.575  1    21.001 ? 1104 ASN A HD21   1 ? 
ATOM   1430 H HD22   . ASN A 1 96  ? 26.366  -20.059 32.293  1    19.03  ? 1104 ASN A HD22   1 ? 
ATOM   1431 N N      . PHE A 1 97  ? 27.83   -18.339 27.459  1    12.874 ? 1105 PHE A N      1 ? 
ATOM   1432 C CA     . PHE A 1 97  ? 29.18   -18.498 26.924  1    13.539 ? 1105 PHE A CA     1 ? 
ATOM   1433 C C      . PHE A 1 97  ? 29.922  -19.686 27.532  1    13.49  ? 1105 PHE A C      1 ? 
ATOM   1434 O O      . PHE A 1 97  ? 31.153  -19.69  27.594  1    15.088 ? 1105 PHE A O      1 ? 
ATOM   1435 C CB     . PHE A 1 97  ? 29.99   -17.207 27.043  1    13.49  ? 1105 PHE A CB     1 ? 
ATOM   1436 C CG     . PHE A 1 97  ? 29.282  -15.992 26.481  1    14.396 ? 1105 PHE A CG     1 ? 
ATOM   1437 C CD1    . PHE A 1 97  ? 29.091  -15.851 25.109  1    15.269 ? 1105 PHE A CD1    1 ? 
ATOM   1438 C CD2    . PHE A 1 97  ? 28.801  -15     27.331  1    14.788 ? 1105 PHE A CD2    1 ? 
ATOM   1439 C CE1    . PHE A 1 97  ? 28.442  -14.718 24.61   1    16.897 ? 1105 PHE A CE1    1 ? 
ATOM   1440 C CE2    . PHE A 1 97  ? 28.147  -13.89  26.82   1    15.757 ? 1105 PHE A CE2    1 ? 
ATOM   1441 C CZ     . PHE A 1 97  ? 27.969  -13.746 25.462  1    14.127 ? 1105 PHE A CZ     1 ? 
ATOM   1442 H H      . PHE A 1 97  ? 27.047  -18.432 26.784  1    13.381 ? 1105 PHE A H      1 ? 
ATOM   1443 H HA     . PHE A 1 97  ? 29.071  -18.705 25.857  1    13.393 ? 1105 PHE A HA     1 c 
ATOM   1444 H HB2    . PHE A 1 97  ? 30.213  -17.031 28.098  1    13.701 ? 1105 PHE A HB2    1 c 
ATOM   1445 H HB3    . PHE A 1 97  ? 30.938  -17.34  26.517  1    13.703 ? 1105 PHE A HB3    1 c 
ATOM   1446 H HD1    . PHE A 1 97  ? 29.462  -16.611 24.429  1    15.396 ? 1105 PHE A HD1    1 c 
ATOM   1447 H HD2    . PHE A 1 97  ? 28.937  -15.101 28.402  1    15.003 ? 1105 PHE A HD2    1 c 
ATOM   1448 H HE1    . PHE A 1 97  ? 28.297  -14.612 23.54   1    15.863 ? 1105 PHE A HE1    1 c 
ATOM   1449 H HE2    . PHE A 1 97  ? 27.782  -13.124 27.496  1    15.383 ? 1105 PHE A HE2    1 c 
ATOM   1450 H HZ     . PHE A 1 97  ? 27.458  -12.873 25.067  1    15.05  ? 1105 PHE A HZ     1 c 
ATOM   1451 N N      . ASP A 1 98  ? 29.172  -20.708 27.948  1    12.843 ? 1106 ASP A N      1 ? 
ATOM   1452 C CA     . ASP A 1 98  ? 29.712  -21.788 28.756  1    11.673 ? 1106 ASP A CA     1 ? 
ATOM   1453 C C      . ASP A 1 98  ? 29.348  -23.179 28.247  1    10.667 ? 1106 ASP A C      1 ? 
ATOM   1454 O O      . ASP A 1 98  ? 29.692  -24.168 28.898  1    12.319 ? 1106 ASP A O      1 ? 
ATOM   1455 C CB     . ASP A 1 98  ? 29.281  -21.638 30.221  1    13.494 ? 1106 ASP A CB     1 ? 
ATOM   1456 C CG     . ASP A 1 98  ? 27.791  -21.786 30.445  1    12.978 ? 1106 ASP A CG     1 ? 
ATOM   1457 O OD1    . ASP A 1 98  ? 27.04   -21.969 29.456  1    14.531 ? 1106 ASP A OD1    1 ? 
ATOM   1458 O OD2    . ASP A 1 98  ? 27.389  -21.719 31.631  1    12.766 ? 1106 ASP A OD2    1 ? 
ATOM   1459 H H      . ASP A 1 98  ? 28.159  -20.701 27.736  1    12.652 ? 1106 ASP A H      1 ? 
ATOM   1460 H HA     . ASP A 1 98  ? 30.8    -21.703 28.748  1    12.057 ? 1106 ASP A HA     1 c 
ATOM   1461 H HB2    . ASP A 1 98  ? 29.795  -22.392 30.821  1    12.965 ? 1106 ASP A HB2    1 c 
ATOM   1462 H HB3    . ASP A 1 98  ? 29.586  -20.653 30.581  1    12.965 ? 1106 ASP A HB3    1 c 
ATOM   1463 N N      . GLY A 1 99  ? 28.656  -23.3   27.114  1    12.312 ? 1107 GLY A N      1 ? 
ATOM   1464 C CA     . GLY A 1 99  ? 28.319  -24.615 26.62   1    13.515 ? 1107 GLY A CA     1 ? 
ATOM   1465 C C      . GLY A 1 99  ? 27.276  -25.372 27.433  1    14.065 ? 1107 GLY A C      1 ? 
ATOM   1466 O O      . GLY A 1 99  ? 27.134  -26.58  27.238  1    14.253 ? 1107 GLY A O      1 ? 
ATOM   1467 H H      . GLY A 1 99  ? 28.308  -22.461 26.619  1    12.225 ? 1107 GLY A H      1 ? 
ATOM   1468 H HA2    . GLY A 1 99  ? 27.96   -24.515 25.593  1    13.352 ? 1107 GLY A HA2    1 c 
ATOM   1469 H HA3    . GLY A 1 99  ? 29.235  -25.207 26.588  1    13.398 ? 1107 GLY A HA3    1 c 
ATOM   1470 N N      . ARG A 1 100 ? 26.544  -24.698 28.32   1    14.12  ? 1108 ARG A N      1 ? 
ATOM   1471 C CA     . ARG A 1 100 ? 25.57   -25.379 29.159  1    14.958 ? 1108 ARG A CA     1 ? 
ATOM   1472 C C      . ARG A 1 100 ? 24.122  -25.01  28.869  1    13.025 ? 1108 ARG A C      1 ? 
ATOM   1473 O O      . ARG A 1 100 ? 23.227  -25.679 29.388  1    14.371 ? 1108 ARG A O      1 ? 
ATOM   1474 C CB     . ARG A 1 100 ? 25.826  -25.062 30.639  1    16.878 ? 1108 ARG A CB     1 ? 
ATOM   1475 C CG     . ARG A 1 100 ? 27.18   -25.547 31.133  1    19.326 ? 1108 ARG A CG     1 ? 
ATOM   1476 C CD     . ARG A 1 100 ? 27.317  -25.454 32.634  1    23.036 ? 1108 ARG A CD     1 ? 
ATOM   1477 N NE     . ARG A 1 100 ? 26.65   -26.595 33.257  1    26.328 ? 1108 ARG A NE     1 ? 
ATOM   1478 C CZ     . ARG A 1 100 ? 25.464  -26.536 33.841  1    26.192 ? 1108 ARG A CZ     1 ? 
ATOM   1479 N NH1    . ARG A 1 100 ? 24.75   -25.426 33.844  1    25.625 ? 1108 ARG A NH1    1 ? 
ATOM   1480 N NH2    . ARG A 1 100 ? 24.991  -27.632 34.434  1    27.136 ? 1108 ARG A NH2    1 ? 
ATOM   1481 H H      . ARG A 1 100 ? 26.744  -23.702 28.511  1    14.415 ? 1108 ARG A H      1 ? 
ATOM   1482 H HA     . ARG A 1 100 ? 25.685  -26.455 29.017  1    14.739 ? 1108 ARG A HA     1 c 
ATOM   1483 H HB2    . ARG A 1 100 ? 25.763  -23.982 30.784  1    17     ? 1108 ARG A HB2    1 c 
ATOM   1484 H HB3    . ARG A 1 100 ? 25.043  -25.527 31.24   1    17.006 ? 1108 ARG A HB3    1 c 
ATOM   1485 H HG2    . ARG A 1 100 ? 27.323  -26.586 30.828  1    19.494 ? 1108 ARG A HG2    1 c 
ATOM   1486 H HG3    . ARG A 1 100 ? 27.967  -24.95  30.668  1    19.452 ? 1108 ARG A HG3    1 c 
ATOM   1487 H HD2    . ARG A 1 100 ? 28.375  -25.461 32.904  1    22.861 ? 1108 ARG A HD2    1 c 
ATOM   1488 H HD3    . ARG A 1 100 ? 26.88   -24.523 32.995  1    22.896 ? 1108 ARG A HD3    1 c 
ATOM   1489 H HE     . ARG A 1 100 ? 27.104  -27.515 33.198  1    23.003 ? 1108 ARG A HE     1 ? 
ATOM   1490 H HH11   . ARG A 1 100 ? 25.128  -24.581 33.44   1    25.79  ? 1108 ARG A HH11   1 ? 
ATOM   1491 H HH12   . ARG A 1 100 ? 23.837  -25.417 34.27   1    24.587 ? 1108 ARG A HH12   1 ? 
ATOM   1492 H HH21   . ARG A 1 100 ? 25.544  -28.479 34.467  1    25.308 ? 1108 ARG A HH21   1 ? 
ATOM   1493 H HH22   . ARG A 1 100 ? 24.061  -27.645 34.839  1    25.874 ? 1108 ARG A HH22   1 ? 
ATOM   1494 N N      . THR A 1 101 ? 23.878  -23.933 28.11   1    12.188 ? 1109 THR A N      1 ? 
ATOM   1495 C CA     . THR A 1 101 ? 22.517  -23.476 27.883  1    12.023 ? 1109 THR A CA     1 ? 
ATOM   1496 C C      . THR A 1 101 ? 22.276  -23.275 26.396  1    12.734 ? 1109 THR A C      1 ? 
ATOM   1497 O O      . THR A 1 101 ? 23.195  -22.993 25.626  1    11.64  ? 1109 THR A O      1 ? 
ATOM   1498 C CB     . THR A 1 101 ? 22.152  -22.181 28.636  1    11.663 ? 1109 THR A CB     1 ? 
ATOM   1499 O OG1    . THR A 1 101 ? 22.617  -21.022 27.948  1    10.775 ? 1109 THR A OG1    1 ? 
ATOM   1500 C CG2    . THR A 1 101 ? 22.676  -22.202 30.065  1    11.671 ? 1109 THR A CG2    1 ? 
ATOM   1501 H H      . THR A 1 101 ? 24.662  -23.441 27.644  1    12.565 ? 1109 THR A H      1 ? 
ATOM   1502 H HA     . THR A 1 101 ? 21.845  -24.261 28.227  1    12.135 ? 1109 THR A HA     1 c 
ATOM   1503 H HB     . THR A 1 101 ? 21.063  -22.126 28.697  1    11.554 ? 1109 THR A HB     1 c 
ATOM   1504 H HG1    . THR A 1 101 ? 23.573  -21.035 27.87   1    10.831 ? 1109 THR A HG1    1 ? 
ATOM   1505 H HG21   . THR A 1 101 ? 22.368  -21.289 30.579  1    11.672 ? 1109 THR A HG21   1 c 
ATOM   1506 H HG22   . THR A 1 101 ? 22.27   -23.069 30.59   1    11.672 ? 1109 THR A HG22   1 c 
ATOM   1507 H HG23   . THR A 1 101 ? 23.766  -22.262 30.054  1    11.681 ? 1109 THR A HG23   1 c 
ATOM   1508 N N      . GLY A 1 102 ? 21      -23.41  26.02   1    13.405 ? 1110 GLY A N      1 ? 
ATOM   1509 C CA     . GLY A 1 102 ? 20.545  -23.018 24.706  1    13.624 ? 1110 GLY A CA     1 ? 
ATOM   1510 C C      . GLY A 1 102 ? 19.294  -22.172 24.846  1    13.299 ? 1110 GLY A C      1 ? 
ATOM   1511 O O      . GLY A 1 102 ? 18.65   -22.178 25.898  1    14.804 ? 1110 GLY A O      1 ? 
ATOM   1512 H H      . GLY A 1 102 ? 20.321  -23.742 26.725  1    12.928 ? 1110 GLY A H      1 ? 
ATOM   1513 H HA2    . GLY A 1 102 ? 21.326  -22.443 24.205  1    13.479 ? 1110 GLY A HA2    1 c 
ATOM   1514 H HA3    . GLY A 1 102 ? 20.334  -23.905 24.106  1    13.526 ? 1110 GLY A HA3    1 c 
ATOM   1515 N N      . SER A 1 103 ? 18.959  -21.438 23.782  1    11.758 ? 1111 SER A N      1 ? 
ATOM   1516 C CA     . SER A 1 103 ? 17.848  -20.506 23.834  1    11.532 ? 1111 SER A CA     1 ? 
ATOM   1517 C C      . SER A 1 103 ? 16.886  -20.705 22.674  1    12.478 ? 1111 SER A C      1 ? 
ATOM   1518 O O      . SER A 1 103 ? 17.302  -21.069 21.561  1    12.658 ? 1111 SER A O      1 ? 
ATOM   1519 C CB     . SER A 1 103 ? 18.33   -19.074 23.822  1    11.914 ? 1111 SER A CB     1 ? 
ATOM   1520 O OG     . SER A 1 103 ? 19.208  -18.87  24.919  1    12.882 ? 1111 SER A OG     1 ? 
ATOM   1521 H H      . SER A 1 103 ? 19.583  -21.436 22.954  1    11.391 ? 1111 SER A H      1 ? 
ATOM   1522 H HA     . SER A 1 103 ? 17.304  -20.679 24.76   1    11.85  ? 1111 SER A HA     1 c 
ATOM   1523 H HB2    . SER A 1 103 ? 18.854  -18.87  22.886  1    12.047 ? 1111 SER A HB2    1 c 
ATOM   1524 H HB3    . SER A 1 103 ? 17.476  -18.398 23.901  1    12.047 ? 1111 SER A HB3    1 c 
ATOM   1525 H HG     . SER A 1 103 ? 19.504  -17.941 24.959  1    13.386 ? 1111 SER A HG     1 ? 
ATOM   1526 N N      . LEU A 1 104 ? 15.62   -20.408 22.945  1    12.741 ? 1112 LEU A N      1 ? 
ATOM   1527 C CA     . LEU A 1 104 ? 14.552  -20.48  21.963  1    12.178 ? 1112 LEU A CA     1 ? 
ATOM   1528 C C      . LEU A 1 104 ? 13.869  -19.126 21.843  1    13.175 ? 1112 LEU A C      1 ? 
ATOM   1529 O O      . LEU A 1 104 ? 13.866  -18.332 22.784  1    12.266 ? 1112 LEU A O      1 ? 
ATOM   1530 C CB     . LEU A 1 104 ? 13.499  -21.519 22.348  1    12.222 ? 1112 LEU A CB     1 ? 
ATOM   1531 C CG     . LEU A 1 104 ? 14.005  -22.917 22.645  1    12.319 ? 1112 LEU A CG     1 ? 
ATOM   1532 C CD1    . LEU A 1 104 ? 12.865  -23.842 23.027  1    12.852 ? 1112 LEU A CD1    1 ? 
ATOM   1533 C CD2    . LEU A 1 104 ? 14.793  -23.493 21.491  1    12.155 ? 1112 LEU A CD2    1 ? 
ATOM   1534 H H      . LEU A 1 104 ? 15.37   -20.074 23.891  1    11.869 ? 1112 LEU A H      1 ? 
ATOM   1535 H HA     . LEU A 1 104 ? 14.983  -20.744 20.995  1    12.464 ? 1112 LEU A HA     1 c 
ATOM   1536 H HB2    . LEU A 1 104 ? 12.968  -21.152 23.228  1    12.233 ? 1112 LEU A HB2    1 c 
ATOM   1537 H HB3    . LEU A 1 104 ? 12.773  -21.583 21.534  1    12.233 ? 1112 LEU A HB3    1 c 
ATOM   1538 H HG     . LEU A 1 104 ? 14.678  -22.853 23.503  1    12.366 ? 1112 LEU A HG     1 c 
ATOM   1539 H HD11   . LEU A 1 104 ? 13.258  -24.839 23.237  1    12.697 ? 1112 LEU A HD11   1 c 
ATOM   1540 H HD12   . LEU A 1 104 ? 12.364  -23.455 23.917  1    12.697 ? 1112 LEU A HD12   1 c 
ATOM   1541 H HD13   . LEU A 1 104 ? 12.15   -23.9   22.204  1    12.687 ? 1112 LEU A HD13   1 c 
ATOM   1542 H HD21   . LEU A 1 104 ? 15.113  -24.507 21.737  1    12.201 ? 1112 LEU A HD21   1 c 
ATOM   1543 H HD22   . LEU A 1 104 ? 14.166  -23.518 20.597  1    12.2   ? 1112 LEU A HD22   1 c 
ATOM   1544 H HD23   . LEU A 1 104 ? 15.67   -22.873 21.3    1    12.204 ? 1112 LEU A HD23   1 c 
ATOM   1545 N N      . CYS A 1 105 ? 13.293  -18.864 20.668  1    12.955 ? 1113 CYS A N      1 ? 
ATOM   1546 C CA     . CYS A 1 105 ? 12.6    -17.637 20.339  1    13.319 ? 1113 CYS A CA     1 ? 
ATOM   1547 C C      . CYS A 1 105 ? 11.181  -18.058 19.931  1    15.336 ? 1113 CYS A C      1 ? 
ATOM   1548 O O      . CYS A 1 105 ? 10.971  -18.601 18.841  1    15.192 ? 1113 CYS A O      1 ? 
ATOM   1549 C CB     . CYS A 1 105 ? 13.354  -16.888 19.242  1    13.797 ? 1113 CYS A CB     1 ? 
ATOM   1550 S SG     . CYS A 1 105 ? 12.524  -15.424 18.603  1    13.15  ? 1113 CYS A SG     1 ? 
ATOM   1551 H H      . CYS A 1 105 ? 13.336  -19.602 19.944  1    11.914 ? 1113 CYS A H      1 ? 
ATOM   1552 H HA     . CYS A 1 105 ? 12.542  -17.02  21.236  1    13.661 ? 1113 CYS A HA     1 c 
ATOM   1553 H HB2    . CYS A 1 105 ? 14.329  -16.587 19.628  1    13.559 ? 1113 CYS A HB2    1 c 
ATOM   1554 H HB3    . CYS A 1 105 ? 13.527  -17.57  18.407  1    13.564 ? 1113 CYS A HB3    1 c 
ATOM   1555 H HG     . CYS A 1 105 ? 13.13   -14.559 19.414  1    13.52  ? 1113 CYS A HG     1 ? 
ATOM   1556 N N      . VAL A 1 106 ? 10.212  -17.856 20.835  1    15.44  ? 1114 VAL A N      1 ? 
ATOM   1557 C CA     . VAL A 1 106 ? 8.933   -18.55  20.778  1    15.152 ? 1114 VAL A CA     1 ? 
ATOM   1558 C C      . VAL A 1 106 ? 7.799   -17.548 20.684  1    15.682 ? 1114 VAL A C      1 ? 
ATOM   1559 O O      . VAL A 1 106 ? 7.616   -16.711 21.574  1    16.877 ? 1114 VAL A O      1 ? 
ATOM   1560 C CB     . VAL A 1 106 ? 8.748   -19.449 22.01   1    15.627 ? 1114 VAL A CB     1 ? 
ATOM   1561 C CG1    . VAL A 1 106 ? 7.377   -20.108 22      1    16.424 ? 1114 VAL A CG1    1 ? 
ATOM   1562 C CG2    . VAL A 1 106 ? 9.853   -20.49  22.086  1    15.824 ? 1114 VAL A CG2    1 ? 
ATOM   1563 H H      . VAL A 1 106 ? 10.421  -17.3   21.679  1    15.367 ? 1114 VAL A H      1 ? 
ATOM   1564 H HA     . VAL A 1 106 ? 8.918   -19.178 19.885  1    15.399 ? 1114 VAL A HA     1 c 
ATOM   1565 H HB     . VAL A 1 106 ? 8.817   -18.811 22.893  1    15.716 ? 1114 VAL A HB     1 c 
ATOM   1566 H HG11   . VAL A 1 106 ? 7.316   -20.831 22.817  1    16.19  ? 1114 VAL A HG11   1 c 
ATOM   1567 H HG12   . VAL A 1 106 ? 6.603   -19.35  22.13   1    16.188 ? 1114 VAL A HG12   1 c 
ATOM   1568 H HG13   . VAL A 1 106 ? 7.227   -20.624 21.049  1    16.167 ? 1114 VAL A HG13   1 c 
ATOM   1569 H HG21   . VAL A 1 106 ? 9.844   -21.099 21.18   1    15.766 ? 1114 VAL A HG21   1 c 
ATOM   1570 H HG22   . VAL A 1 106 ? 10.82   -19.99  22.178  1    15.765 ? 1114 VAL A HG22   1 c 
ATOM   1571 H HG23   . VAL A 1 106 ? 9.693   -21.13  22.956  1    15.758 ? 1114 VAL A HG23   1 c 
ATOM   1572 N N      . ARG A 1 107 ? 7.001   -17.67  19.611  1    17.564 ? 1115 ARG A N      1 ? 
ATOM   1573 C CA     . ARG A 1 107 ? 5.797   -16.851 19.497  1    17.724 ? 1115 ARG A CA     1 ? 
ATOM   1574 C C      . ARG A 1 107 ? 4.646   -17.548 20.224  1    18.962 ? 1115 ARG A C      1 ? 
ATOM   1575 O O      . ARG A 1 107 ? 4.366   -18.733 20.015  1    16.951 ? 1115 ARG A O      1 ? 
ATOM   1576 C CB     . ARG A 1 107 ? 5.476   -16.577 18.022  1    19.219 ? 1115 ARG A CB     1 ? 
ATOM   1577 C CG     . ARG A 1 107 ? 4.131   -16.081 17.533  1    22.264 ? 1115 ARG A CG     1 ? 
ATOM   1578 C CD     . ARG A 1 107 ? 3.93    -14.742 18.203  1    28.117 ? 1115 ARG A CD     1 ? 
ATOM   1579 N NE     . ARG A 1 107 ? 2.792   -14.017 17.616  1    38.383 ? 1115 ARG A NE     1 ? 
ATOM   1580 C CZ     . ARG A 1 107 ? 1.685   -13.704 18.28   1    42.664 ? 1115 ARG A CZ     1 ? 
ATOM   1581 N NH1    . ARG A 1 107 ? 1.59    -13.971 19.591  1    44.926 ? 1115 ARG A NH1    1 ? 
ATOM   1582 N NH2    . ARG A 1 107 ? 0.693   -13.069 17.645  1    44.005 ? 1115 ARG A NH2    1 ? 
ATOM   1583 H H      . ARG A 1 107 ? 7.207   -18.371 18.872  1    17.741 ? 1115 ARG A H      1 ? 
ATOM   1584 H HA     . ARG A 1 107 ? 5.986   -15.895 19.987  1    18.104 ? 1115 ARG A HA     1 c 
ATOM   1585 H HB2    . ARG A 1 107 ? 6.222   -15.857 17.679  1    19.507 ? 1115 ARG A HB2    1 c 
ATOM   1586 H HB3    . ARG A 1 107 ? 5.684   -17.507 17.488  1    19.507 ? 1115 ARG A HB3    1 c 
ATOM   1587 H HG2    . ARG A 1 107 ? 4.139   -15.958 16.449  1    22.744 ? 1115 ARG A HG2    1 c 
ATOM   1588 H HG3    . ARG A 1 107 ? 3.338   -16.77  17.831  1    22.688 ? 1115 ARG A HG3    1 c 
ATOM   1589 H HD2    . ARG A 1 107 ? 3.759   -14.898 19.267  1    28.686 ? 1115 ARG A HD2    1 c 
ATOM   1590 H HD3    . ARG A 1 107 ? 4.835   -14.141 18.091  1    28.672 ? 1115 ARG A HD3    1 c 
ATOM   1591 H HE     . ARG A 1 107 ? 2.851   -13.752 16.623  1    37.245 ? 1115 ARG A HE     1 ? 
ATOM   1592 H HH11   . ARG A 1 107 ? 2.379   -14.259 20.156  1    37.668 ? 1115 ARG A HH11   1 ? 
ATOM   1593 H HH12   . ARG A 1 107 ? 0.7     -13.801 20.037  1    42.675 ? 1115 ARG A HH12   1 ? 
ATOM   1594 H HH21   . ARG A 1 107 ? 0.807   -12.659 16.717  1    37.848 ? 1115 ARG A HH21   1 ? 
ATOM   1595 H HH22   . ARG A 1 107 ? -0.17   -12.929 18.142  1    42.064 ? 1115 ARG A HH22   1 ? 
ATOM   1596 N N      . ARG A 1 108 ? 3.991   -16.808 21.102  1    15.695 ? 1116 ARG A N      1 ? 
ATOM   1597 C CA     . ARG A 1 108 ? 2.876   -17.375 21.857  1    17.108 ? 1116 ARG A CA     1 ? 
ATOM   1598 C C      . ARG A 1 108 ? 1.671   -17.486 20.926  1    16.823 ? 1116 ARG A C      1 ? 
ATOM   1599 O O      . ARG A 1 108 ? 1.209   -16.482 20.389  1    19.271 ? 1116 ARG A O      1 ? 
ATOM   1600 C CB     . ARG A 1 108 ? 2.561   -16.478 23.049  1    17.987 ? 1116 ARG A CB     1 ? 
ATOM   1601 C CG     . ARG A 1 108 ? 1.573   -17.044 24.032  1    21.783 ? 1116 ARG A CG     1 ? 
ATOM   1602 C CD     . ARG A 1 108 ? 1.119   -16.002 25.038  1    24.849 ? 1116 ARG A CD     1 ? 
ATOM   1603 N NE     . ARG A 1 108 ? 2.114   -15.686 26.066  1    22.87  ? 1116 ARG A NE     1 ? 
ATOM   1604 C CZ     . ARG A 1 108 ? 2.24    -16.339 27.214  1    22.651 ? 1116 ARG A CZ     1 ? 
ATOM   1605 N NH1    . ARG A 1 108 ? 1.589   -17.463 27.437  1    21.751 ? 1116 ARG A NH1    1 ? 
ATOM   1606 N NH2    . ARG A 1 108 ? 3.041   -15.863 28.167  1    22.432 ? 1116 ARG A NH2    1 ? 
ATOM   1607 H H      . ARG A 1 108 ? 4.249   -15.819 21.242  1    14.412 ? 1116 ARG A H      1 ? 
ATOM   1608 H HA     . ARG A 1 108 ? 3.157   -18.371 22.206  1    16.932 ? 1116 ARG A HA     1 c 
ATOM   1609 H HB2    . ARG A 1 108 ? 3.493   -16.266 23.577  1    18.563 ? 1116 ARG A HB2    1 c 
ATOM   1610 H HB3    . ARG A 1 108 ? 2.172   -15.529 22.674  1    18.563 ? 1116 ARG A HB3    1 c 
ATOM   1611 H HG2    . ARG A 1 108 ? 0.702   -17.423 23.494  1    21.466 ? 1116 ARG A HG2    1 c 
ATOM   1612 H HG3    . ARG A 1 108 ? 2.032   -17.879 24.566  1    21.486 ? 1116 ARG A HG3    1 c 
ATOM   1613 H HD2    . ARG A 1 108 ? 0.866   -15.088 24.498  1    23.694 ? 1116 ARG A HD2    1 c 
ATOM   1614 H HD3    . ARG A 1 108 ? 0.208   -16.359 25.523  1    23.679 ? 1116 ARG A HD3    1 c 
ATOM   1615 H HE     . ARG A 1 108 ? 2.772   -14.963 25.908  1    22.447 ? 1116 ARG A HE     1 ? 
ATOM   1616 H HH11   . ARG A 1 108 ? 0.929   -17.891 26.805  1    22.659 ? 1116 ARG A HH11   1 ? 
ATOM   1617 H HH12   . ARG A 1 108 ? 1.753   -17.917 28.316  1    23     ? 1116 ARG A HH12   1 ? 
ATOM   1618 H HH21   . ARG A 1 108 ? 3.479   -14.985 28.21   1    21.714 ? 1116 ARG A HH21   1 ? 
ATOM   1619 H HH22   . ARG A 1 108 ? 3.121   -16.44  29.003  1    20.313 ? 1116 ARG A HH22   1 ? 
ATOM   1620 N N      . ALA A 1 109 ? 1.16    -18.701 20.729  1    17.648 ? 1117 ALA A N      1 ? 
ATOM   1621 C CA     . ALA A 1 109 ? 0.012   -18.936 19.857  1    18.477 ? 1117 ALA A CA     1 ? 
ATOM   1622 C C      . ALA A 1 109 ? -1.272  -18.819 20.678  1    18.59  ? 1117 ALA A C      1 ? 
ATOM   1623 O O      . ALA A 1 109 ? -1.569  -19.704 21.496  1    17.703 ? 1117 ALA A O      1 ? 
ATOM   1624 C CB     . ALA A 1 109 ? 0.114   -20.298 19.188  1    18.391 ? 1117 ALA A CB     1 ? 
ATOM   1625 H H      . ALA A 1 109 ? 1.581   -19.527 21.165  1    17.829 ? 1117 ALA A H      1 ? 
ATOM   1626 H HA     . ALA A 1 109 ? -0.001  -18.161 19.088  1    18.522 ? 1117 ALA A HA     1 c 
ATOM   1627 H HB1    . ALA A 1 109 ? 0.177   -21.076 19.95   1    18.394 ? 1117 ALA A HB1    1 c 
ATOM   1628 H HB2    . ALA A 1 109 ? -0.767  -20.47  18.567  1    18.406 ? 1117 ALA A HB2    1 c 
ATOM   1629 H HB3    . ALA A 1 109 ? 1.009   -20.333 18.562  1    18.389 ? 1117 ALA A HB3    1 c 
ATOM   1630 N N      . VAL A 1 110 ? -2.014  -17.733 20.471  1    20.534 ? 1118 VAL A N      1 ? 
ATOM   1631 C CA     . VAL A 1 110 ? -3.243  -17.465 21.211  1    24.474 ? 1118 VAL A CA     1 ? 
ATOM   1632 C C      . VAL A 1 110 ? -4.417  -17.443 20.238  1    24.416 ? 1118 VAL A C      1 ? 
ATOM   1633 O O      . VAL A 1 110 ? -4.332  -16.862 19.156  1    24.17  ? 1118 VAL A O      1 ? 
ATOM   1634 C CB     . VAL A 1 110 ? -3.183  -16.149 22.007  1    29.291 ? 1118 VAL A CB     1 ? 
ATOM   1635 C CG1    . VAL A 1 110 ? -4.42   -15.99  22.869  1    32.423 ? 1118 VAL A CG1    1 ? 
ATOM   1636 C CG2    . VAL A 1 110 ? -1.928  -16.096 22.862  1    32.079 ? 1118 VAL A CG2    1 ? 
ATOM   1637 H H      . VAL A 1 110 ? -1.775  -17.075 19.721  1    22.077 ? 1118 VAL A H      1 ? 
ATOM   1638 H HA     . VAL A 1 110 ? -3.398  -18.281 21.915  1    24.373 ? 1118 VAL A HA     1 c 
ATOM   1639 H HB     . VAL A 1 110 ? -3.151  -15.329 21.286  1    29.359 ? 1118 VAL A HB     1 c 
ATOM   1640 H HG11   . VAL A 1 110 ? -5.306  -15.932 22.233  1    31.449 ? 1118 VAL A HG11   1 c 
ATOM   1641 H HG12   . VAL A 1 110 ? -4.509  -16.846 23.539  1    31.517 ? 1118 VAL A HG12   1 c 
ATOM   1642 H HG13   . VAL A 1 110 ? -4.338  -15.075 23.458  1    31.375 ? 1118 VAL A HG13   1 c 
ATOM   1643 H HG21   . VAL A 1 110 ? -1.912  -16.952 23.541  1    31.224 ? 1118 VAL A HG21   1 c 
ATOM   1644 H HG22   . VAL A 1 110 ? -1.046  -16.126 22.22   1    31.163 ? 1118 VAL A HG22   1 c 
ATOM   1645 H HG23   . VAL A 1 110 ? -1.922  -15.172 23.444  1    31.121 ? 1118 VAL A HG23   1 c 
ATOM   1646 N N      . TYR A 1 111 ? -5.511  -18.102 20.625  1    26.417 ? 1119 TYR A N      1 ? 
ATOM   1647 C CA     . TYR A 1 111 ? -6.711  -18.155 19.812  1    25.67  ? 1119 TYR A CA     1 ? 
ATOM   1648 C C      . TYR A 1 111 ? -7.648  -16.993 20.144  1    22.161 ? 1119 TYR A C      1 ? 
ATOM   1649 O O      . TYR A 1 111 ? -7.899  -16.704 21.319  1    19.956 ? 1119 TYR A O      1 ? 
ATOM   1650 C CB     . TYR A 1 111 ? -7.454  -19.463 20.08   1    27.388 ? 1119 TYR A CB     1 ? 
ATOM   1651 C CG     . TYR A 1 111 ? -8.768  -19.526 19.332  1    27.659 ? 1119 TYR A CG     1 ? 
ATOM   1652 C CD1    . TYR A 1 111 ? -8.809  -19.97  18.025  1    24.41  ? 1119 TYR A CD1    1 ? 
ATOM   1653 C CD2    . TYR A 1 111 ? -9.943  -19.09  19.92   1    27.412 ? 1119 TYR A CD2    1 ? 
ATOM   1654 C CE1    . TYR A 1 111 ? -9.99   -20.011 17.326  1    29.222 ? 1119 TYR A CE1    1 ? 
ATOM   1655 C CE2    . TYR A 1 111 ? -11.139 -19.129 19.234  1    26.128 ? 1119 TYR A CE2    1 ? 
ATOM   1656 C CZ     . TYR A 1 111 ? -11.162 -19.59  17.931  1    29.358 ? 1119 TYR A CZ     1 ? 
ATOM   1657 O OH     . TYR A 1 111 ? -12.345 -19.632 17.25   1    31.358 ? 1119 TYR A OH     1 ? 
ATOM   1658 H H      . TYR A 1 111 ? -5.489  -18.696 21.481  1    23.955 ? 1119 TYR A H      1 ? 
ATOM   1659 H HA     . TYR A 1 111 ? -6.434  -18.108 18.757  1    25.419 ? 1119 TYR A HA     1 c 
ATOM   1660 H HB2    . TYR A 1 111 ? -6.823  -20.297 19.768  1    27.036 ? 1119 TYR A HB2    1 c 
ATOM   1661 H HB3    . TYR A 1 111 ? -7.645  -19.549 21.152  1    27.058 ? 1119 TYR A HB3    1 c 
ATOM   1662 H HD1    . TYR A 1 111 ? -7.895  -20.303 17.544  1    26.156 ? 1119 TYR A HD1    1 c 
ATOM   1663 H HD2    . TYR A 1 111 ? -9.927  -18.729 20.943  1    27.189 ? 1119 TYR A HD2    1 c 
ATOM   1664 H HE1    . TYR A 1 111 ? -10.007 -20.378 16.305  1    28.104 ? 1119 TYR A HE1    1 c 
ATOM   1665 H HE2    . TYR A 1 111 ? -12.056 -18.799 19.711  1    27.113 ? 1119 TYR A HE2    1 c 
ATOM   1666 H HH     . TYR A 1 111 ? -12.177 -19.929 16.344  1    32.333 ? 1119 TYR A HH     1 ? 
ATOM   1667 N N      . TYR A 1 112 ? -8.183  -16.368 19.097  1    25.487 ? 1120 TYR A N      1 ? 
ATOM   1668 C CA     . TYR A 1 112 ? -9.236  -15.369 19.214  1    26.609 ? 1120 TYR A CA     1 ? 
ATOM   1669 C C      . TYR A 1 112 ? -10.362 -15.726 18.253  1    25.496 ? 1120 TYR A C      1 ? 
ATOM   1670 O O      . TYR A 1 112 ? -10.108 -16.025 17.09   1    23.562 ? 1120 TYR A O      1 ? 
ATOM   1671 C CB     . TYR A 1 112 ? -8.72   -13.976 18.858  1    32.829 ? 1120 TYR A CB     1 ? 
ATOM   1672 C CG     . TYR A 1 112 ? -7.519  -13.57  19.682  1    35.943 ? 1120 TYR A CG     1 ? 
ATOM   1673 C CD1    . TYR A 1 112 ? -7.692  -12.924 20.91   1    37.33  ? 1120 TYR A CD1    1 ? 
ATOM   1674 C CD2    . TYR A 1 112 ? -6.221  -13.752 19.203  1    35.38  ? 1120 TYR A CD2    1 ? 
ATOM   1675 C CE1    . TYR A 1 112 ? -6.603  -12.524 21.671  1    42.145 ? 1120 TYR A CE1    1 ? 
ATOM   1676 C CE2    . TYR A 1 112 ? -5.122  -13.379 19.97   1    31.419 ? 1120 TYR A CE2    1 ? 
ATOM   1677 C CZ     . TYR A 1 112 ? -5.315  -12.761 21.204  1    40.004 ? 1120 TYR A CZ     1 ? 
ATOM   1678 O OH     . TYR A 1 112 ? -4.284  -12.351 22.016  1    41.727 ? 1120 TYR A OH     1 ? 
ATOM   1679 H H      . TYR A 1 112 ? -7.854  -16.65  18.157  1    24.168 ? 1120 TYR A H      1 ? 
ATOM   1680 H HA     . TYR A 1 112 ? -9.619  -15.364 20.237  1    27.136 ? 1120 TYR A HA     1 c 
ATOM   1681 H HB2    . TYR A 1 112 ? -8.449  -13.962 17.8    1    31.975 ? 1120 TYR A HB2    1 c 
ATOM   1682 H HB3    . TYR A 1 112 ? -9.523  -13.254 19.019  1    31.929 ? 1120 TYR A HB3    1 c 
ATOM   1683 H HD1    . TYR A 1 112 ? -8.694  -12.753 21.287  1    37.968 ? 1120 TYR A HD1    1 c 
ATOM   1684 H HD2    . TYR A 1 112 ? -6.065  -14.25  18.252  1    34.661 ? 1120 TYR A HD2    1 c 
ATOM   1685 H HE1    . TYR A 1 112 ? -6.754  -12.054 22.638  1    40.449 ? 1120 TYR A HE1    1 c 
ATOM   1686 H HE2    . TYR A 1 112 ? -4.116  -13.551 19.601  1    34.094 ? 1120 TYR A HE2    1 c 
ATOM   1687 H HH     . TYR A 1 112 ? -3.406  -12.597 21.68   1    37.946 ? 1120 TYR A HH     1 ? 
ATOM   1688 N N      . ASP A 1 113 ? -11.599 -15.684 18.732  1    21.55  ? 1121 ASP A N      1 ? 
ATOM   1689 C CA     . ASP A 1 113 ? -12.702 -15.929 17.83   1    23.071 ? 1121 ASP A CA     1 ? 
ATOM   1690 C C      . ASP A 1 113 ? -12.645 -14.885 16.724  1    21.38  ? 1121 ASP A C      1 ? 
ATOM   1691 O O      . ASP A 1 113 ? -12.423 -13.698 17.005  1    24.715 ? 1121 ASP A O      1 ? 
ATOM   1692 C CB     . ASP A 1 113 ? -14.034 -15.813 18.555  1    22.729 ? 1121 ASP A CB     1 ? 
ATOM   1693 C CG     . ASP A 1 113 ? -15.202 -15.979 17.61   1    21.537 ? 1121 ASP A CG     1 ? 
ATOM   1694 O OD1    . ASP A 1 113 ? -15.554 -17.143 17.322  1    17.901 ? 1121 ASP A OD1    1 ? 
ATOM   1695 O OD2    . ASP A 1 113 ? -15.739 -14.957 17.133  1    19.838 ? 1121 ASP A OD2    1 ? 
ATOM   1696 H H      . ASP A 1 113 ? -11.784 -15.498 19.733  1    21.743 ? 1121 ASP A H      1 ? 
ATOM   1697 H HA     . ASP A 1 113 ? -12.594 -16.928 17.407  1    22.418 ? 1121 ASP A HA     1 c 
ATOM   1698 H HB2    . ASP A 1 113 ? -14.095 -16.582 19.328  1    22.534 ? 1121 ASP A HB2    1 c 
ATOM   1699 H HB3    . ASP A 1 113 ? -14.104 -14.834 19.034  1    22.534 ? 1121 ASP A HB3    1 c 
ATOM   1700 N N      . PRO A 1 114 ? -12.812 -15.272 15.451  1    20.823 ? 1122 PRO A N      1 ? 
ATOM   1701 C CA     . PRO A 1 114 ? -12.635 -14.306 14.363  1    23.862 ? 1122 PRO A CA     1 ? 
ATOM   1702 C C      . PRO A 1 114 ? -13.648 -13.162 14.367  1    28.379 ? 1122 PRO A C      1 ? 
ATOM   1703 O O      . PRO A 1 114 ? -13.4   -12.108 13.787  1    29.903 ? 1122 PRO A O      1 ? 
ATOM   1704 C CB     . PRO A 1 114 ? -12.818 -15.14  13.091  1    23.229 ? 1122 PRO A CB     1 ? 
ATOM   1705 C CG     . PRO A 1 114 ? -12.563 -16.56  13.519  1    21.937 ? 1122 PRO A CG     1 ? 
ATOM   1706 C CD     . PRO A 1 114 ? -12.912 -16.657 14.966  1    23.297 ? 1122 PRO A CD     1 ? 
ATOM   1707 H HA     . PRO A 1 114 ? -11.623 -13.899 14.396  1    23.875 ? 1122 PRO A HA     1 c 
ATOM   1708 H HB2    . PRO A 1 114 ? -13.831 -15.03  12.697  1    23.102 ? 1122 PRO A HB2    1 c 
ATOM   1709 H HB3    . PRO A 1 114 ? -12.108 -14.833 12.321  1    23.078 ? 1122 PRO A HB3    1 c 
ATOM   1710 H HG2    . PRO A 1 114 ? -13.177 -17.25  12.937  1    22.507 ? 1122 PRO A HG2    1 c 
ATOM   1711 H HG3    . PRO A 1 114 ? -11.513 -16.82  13.368  1    22.508 ? 1122 PRO A HG3    1 c 
ATOM   1712 H HD2    . PRO A 1 114 ? -13.925 -17.04  15.103  1    22.429 ? 1122 PRO A HD2    1 c 
ATOM   1713 H HD3    . PRO A 1 114 ? -12.209 -17.303 15.495  1    22.431 ? 1122 PRO A HD3    1 c 
ATOM   1714 N N      . GLU A 1 115 ? -14.826 -13.401 14.976  1    29.067 ? 1123 GLU A N      1 ? 
ATOM   1715 C CA     . GLU A 1 115 ? -15.918 -12.448 15.007  1    30.851 ? 1123 GLU A CA     1 ? 
ATOM   1716 C C      . GLU A 1 115 ? -15.904 -11.623 16.298  1    29.328 ? 1123 GLU A C      1 ? 
ATOM   1717 O O      . GLU A 1 115 ? -15.986 -10.393 16.229  1    31.576 ? 1123 GLU A O      1 ? 
ATOM   1718 C CB     . GLU A 1 115 ? -17.205 -13.245 14.766  1    36.067 ? 1123 GLU A CB     1 ? 
ATOM   1719 C CG     . GLU A 1 115 ? -18.499 -12.58  15.245  1    41.157 ? 1123 GLU A CG     1 ? 
ATOM   1720 C CD     . GLU A 1 115 ? -19.499 -12.182 14.176  1    42.761 ? 1123 GLU A CD     1 ? 
ATOM   1721 O OE1    . GLU A 1 115 ? -19.3   -12.527 12.991  1    46.509 ? 1123 GLU A OE1    1 ? 
ATOM   1722 O OE2    . GLU A 1 115 ? -20.49  -11.519 14.543  1    45.076 ? 1123 GLU A OE2    1 ? 
ATOM   1723 H H      . GLU A 1 115 ? -14.993 -14.319 15.419  1    32.443 ? 1123 GLU A H      1 ? 
ATOM   1724 H HA     . GLU A 1 115 ? -15.792 -11.762 14.167  1    31.078 ? 1123 GLU A HA     1 c 
ATOM   1725 H HB2    . GLU A 1 115 ? -17.284 -13.466 13.705  1    36.192 ? 1123 GLU A HB2    1 c 
ATOM   1726 H HB3    . GLU A 1 115 ? -17.121 -14.198 15.291  1    35.782 ? 1123 GLU A HB3    1 c 
ATOM   1727 H HG2    . GLU A 1 115 ? -19     -13.256 15.939  1    40.313 ? 1123 GLU A HG2    1 c 
ATOM   1728 H HG3    . GLU A 1 115 ? -18.243 -11.683 15.812  1    40.247 ? 1123 GLU A HG3    1 c 
ATOM   1729 N N      . THR A 1 116 ? -15.898 -12.276 17.467  1    26.381 ? 1124 THR A N      1 ? 
ATOM   1730 C CA     . THR A 1 116 ? -16.036 -11.558 18.729  1    29.076 ? 1124 THR A CA     1 ? 
ATOM   1731 C C      . THR A 1 116 ? -14.693 -11.25  19.415  1    31.221 ? 1124 THR A C      1 ? 
ATOM   1732 O O      . THR A 1 116 ? -14.723 -10.491 20.382  1    31.844 ? 1124 THR A O      1 ? 
ATOM   1733 C CB     . THR A 1 116 ? -16.951 -12.286 19.728  1    26.66  ? 1124 THR A CB     1 ? 
ATOM   1734 O OG1    . THR A 1 116 ? -16.162 -13.355 20.25   1    28.475 ? 1124 THR A OG1    1 ? 
ATOM   1735 C CG2    . THR A 1 116 ? -18.233 -12.831 19.115  1    26.113 ? 1124 THR A CG2    1 ? 
ATOM   1736 H H      . THR A 1 116 ? -15.806 -13.309 17.479  1    25.511 ? 1124 THR A H      1 ? 
ATOM   1737 H HA     . THR A 1 116 ? -16.51  -10.602 18.501  1    28.488 ? 1124 THR A HA     1 c 
ATOM   1738 H HB     . THR A 1 116 ? -17.212 -11.604 20.54   1    27.309 ? 1124 THR A HB     1 c 
ATOM   1739 H HG1    . THR A 1 116 ? -16.114 -14.107 19.613  1    29.035 ? 1124 THR A HG1    1 ? 
ATOM   1740 H HG21   . THR A 1 116 ? -18.815 -12.008 18.695  1    26.275 ? 1124 THR A HG21   1 c 
ATOM   1741 H HG22   . THR A 1 116 ? -17.986 -13.542 18.323  1    26.276 ? 1124 THR A HG22   1 c 
ATOM   1742 H HG23   . THR A 1 116 ? -18.821 -13.336 19.885  1    26.31  ? 1124 THR A HG23   1 c 
ATOM   1743 N N      . GLY A 1 117 ? -13.551 -11.838 18.989  1    29.408 ? 1125 GLY A N      1 ? 
ATOM   1744 C CA     . GLY A 1 117 ? -12.269 -11.642 19.661  1    28.077 ? 1125 GLY A CA     1 ? 
ATOM   1745 C C      . GLY A 1 117 ? -12.077 -12.498 20.917  1    34.525 ? 1125 GLY A C      1 ? 
ATOM   1746 O O      . GLY A 1 117 ? -10.989 -12.531 21.495  1    37.226 ? 1125 GLY A O      1 ? 
ATOM   1747 H H      . GLY A 1 117 ? -13.553 -12.371 18.101  1    29.206 ? 1125 GLY A H      1 ? 
ATOM   1748 H HA2    . GLY A 1 117 ? -11.47  -11.87  18.953  1    29.669 ? 1125 GLY A HA2    1 c 
ATOM   1749 H HA3    . GLY A 1 117 ? -12.175 -10.588 19.931  1    29.847 ? 1125 GLY A HA3    1 c 
ATOM   1750 N N      . LYS A 1 118 ? -13.124 -13.215 21.336  1    33.222 ? 1126 LYS A N      1 ? 
ATOM   1751 C CA     . LYS A 1 118 ? -13.111 -13.995 22.575  1    35.774 ? 1126 LYS A CA     1 ? 
ATOM   1752 C C      . LYS A 1 118 ? -12.095 -15.149 22.533  1    35.259 ? 1126 LYS A C      1 ? 
ATOM   1753 O O      . LYS A 1 118 ? -12.046 -15.921 21.57   1    33.736 ? 1126 LYS A O      1 ? 
ATOM   1754 C CB     . LYS A 1 118 ? -14.496 -14.559 22.939  1    36.603 ? 1126 LYS A CB     1 ? 
ATOM   1755 C CG     . LYS A 1 118 ? -15.502 -13.496 23.403  1    42.596 ? 1126 LYS A CG     1 ? 
ATOM   1756 C CD     . LYS A 1 118 ? -16.79  -14.035 24.025  1    49.25  ? 1126 LYS A CD     1 ? 
ATOM   1757 C CE     . LYS A 1 118 ? -17.803 -12.956 24.301  1    54.441 ? 1126 LYS A CE     1 ? 
ATOM   1758 N NZ     . LYS A 1 118 ? -19.182 -13.47  24.382  1    55.7   ? 1126 LYS A NZ     1 ? 
ATOM   1759 H H      . LYS A 1 118 ? -13.978 -13.201 20.754  1    32.265 ? 1126 LYS A H      1 ? 
ATOM   1760 H HA     . LYS A 1 118 ? -12.815 -13.323 23.383  1    35.265 ? 1126 LYS A HA     1 c 
ATOM   1761 H HB2    . LYS A 1 118 ? -14.909 -15.071 22.067  1    37.649 ? 1126 LYS A HB2    1 c 
ATOM   1762 H HB3    . LYS A 1 118 ? -14.379 -15.298 23.734  1    37.649 ? 1126 LYS A HB3    1 c 
ATOM   1763 H HG2    . LYS A 1 118 ? -15.005 -12.855 24.133  1    42.511 ? 1126 LYS A HG2    1 c 
ATOM   1764 H HG3    . LYS A 1 118 ? -15.761 -12.871 22.547  1    42.419 ? 1126 LYS A HG3    1 c 
ATOM   1765 H HD2    . LYS A 1 118 ? -17.23  -14.771 23.348  1    48.79  ? 1126 LYS A HD2    1 c 
ATOM   1766 H HD3    . LYS A 1 118 ? -16.547 -14.543 24.961  1    48.791 ? 1126 LYS A HD3    1 c 
ATOM   1767 H HE2    . LYS A 1 118 ? -17.555 -12.459 25.242  1    53.538 ? 1126 LYS A HE2    1 c 
ATOM   1768 H HE3    . LYS A 1 118 ? -17.755 -12.21  23.505  1    53.537 ? 1126 LYS A HE3    1 c 
ATOM   1769 H HZ1    . LYS A 1 118 ? -19.382 -14.292 23.787  1    48.236 ? 1126 LYS A HZ1    1 ? 
ATOM   1770 H HZ2    . LYS A 1 118 ? -19.396 -13.719 25.346  1    50.723 ? 1126 LYS A HZ2    1 ? 
ATOM   1771 H HZ3    . LYS A 1 118 ? -19.784 -12.702 24.108  1    50.448 ? 1126 LYS A HZ3    1 ? 
ATOM   1772 N N      . GLU A 1 119 ? -11.325 -15.294 23.631  1    29.164 ? 1127 GLU A N      1 ? 
ATOM   1773 C CA     . GLU A 1 119 ? -10.241 -16.278 23.747  1    27.911 ? 1127 GLU A CA     1 ? 
ATOM   1774 C C      . GLU A 1 119 ? -10.817 -17.636 24.18   1    27.661 ? 1127 GLU A C      1 ? 
ATOM   1775 O O      . GLU A 1 119 ? -12.023 -17.712 24.462  1    28.389 ? 1127 GLU A O      1 ? 
ATOM   1776 C CB     . GLU A 1 119 ? -9.181  -15.731 24.724  1    31.34  ? 1127 GLU A CB     1 ? 
ATOM   1777 C CG     . GLU A 1 119 ? -8.467  -14.446 24.265  1    34.957 ? 1127 GLU A CG     1 ? 
ATOM   1778 C CD     . GLU A 1 119 ? -7.732  -13.643 25.36   1    41.119 ? 1127 GLU A CD     1 ? 
ATOM   1779 O OE1    . GLU A 1 119 ? -7.436  -14.209 26.436  1    41.33  ? 1127 GLU A OE1    1 ? 
ATOM   1780 O OE2    . GLU A 1 119 ? -7.458  -12.433 25.168  1    38.699 ? 1127 GLU A OE2    1 ? 
ATOM   1781 H H      . GLU A 1 119 ? -11.528 -14.682 24.443  1    27.986 ? 1127 GLU A H      1 ? 
ATOM   1782 H HA     . GLU A 1 119 ? -9.783  -16.395 22.765  1    28.634 ? 1127 GLU A HA     1 c 
ATOM   1783 H HB2    . GLU A 1 119 ? -9.665  -15.53  25.682  1    31.292 ? 1127 GLU A HB2    1 c 
ATOM   1784 H HB3    . GLU A 1 119 ? -8.429  -16.504 24.891  1    31.274 ? 1127 GLU A HB3    1 c 
ATOM   1785 H HG2    . GLU A 1 119 ? -7.741  -14.709 23.493  1    35.361 ? 1127 GLU A HG2    1 c 
ATOM   1786 H HG3    . GLU A 1 119 ? -9.203  -13.788 23.799  1    35.33  ? 1127 GLU A HG3    1 c 
ATOM   1787 N N      . ASP A 1 120 ? -9.984  -18.705 24.258  1    23.603 ? 1128 ASP A N      1 ? 
ATOM   1788 C CA     . ASP A 1 120 ? -10.444 -20.02  24.694  1    25.754 ? 1128 ASP A CA     1 ? 
ATOM   1789 C C      . ASP A 1 120 ? -9.216  -20.89  24.997  1    28.592 ? 1128 ASP A C      1 ? 
ATOM   1790 O O      . ASP A 1 120 ? -8.537  -21.38  24.083  1    25.415 ? 1128 ASP A O      1 ? 
ATOM   1791 C CB     . ASP A 1 120 ? -11.388 -20.635 23.685  1    22.292 ? 1128 ASP A CB     1 ? 
ATOM   1792 C CG     . ASP A 1 120 ? -11.742 -22.113 23.855  1    24.365 ? 1128 ASP A CG     1 ? 
ATOM   1793 O OD1    . ASP A 1 120 ? -11.26  -22.796 24.794  1    18.897 ? 1128 ASP A OD1    1 ? 
ATOM   1794 O OD2    . ASP A 1 120 ? -12.56  -22.58  23.03   1    26.556 ? 1128 ASP A OD2    1 ? 
ATOM   1795 H H      . ASP A 1 120 ? -8.978  -18.616 24.038  1    25.192 ? 1128 ASP A H      1 ? 
ATOM   1796 H HA     . ASP A 1 120 ? -11.014 -19.887 25.613  1    25.184 ? 1128 ASP A HA     1 c 
ATOM   1797 H HB2    . ASP A 1 120 ? -12.321 -20.073 23.702  1    23.599 ? 1128 ASP A HB2    1 c 
ATOM   1798 H HB3    . ASP A 1 120 ? -10.949 -20.513 22.693  1    23.494 ? 1128 ASP A HB3    1 c 
ATOM   1799 N N      . PRO A 1 121 ? -8.97   -21.185 26.289  1    28.114 ? 1129 PRO A N      1 ? 
ATOM   1800 C CA     . PRO A 1 121 ? -7.68   -21.706 26.708  1    28.907 ? 1129 PRO A CA     1 ? 
ATOM   1801 C C      . PRO A 1 121 ? -7.408  -23.012 25.996  1    32.381 ? 1129 PRO A C      1 ? 
ATOM   1802 O O      . PRO A 1 121 ? -6.251  -23.349 25.722  1    30.363 ? 1129 PRO A O      1 ? 
ATOM   1803 C CB     . PRO A 1 121 ? -7.817  -22.038 28.223  1    28.278 ? 1129 PRO A CB     1 ? 
ATOM   1804 C CG     . PRO A 1 121 ? -9.233  -21.587 28.661  1    26.999 ? 1129 PRO A CG     1 ? 
ATOM   1805 C CD     . PRO A 1 121 ? -9.967  -21.1   27.39   1    29.315 ? 1129 PRO A CD     1 ? 
ATOM   1806 H HA     . PRO A 1 121 ? -6.885  -20.982 26.518  1    29.234 ? 1129 PRO A HA     1 c 
ATOM   1807 H HB2    . PRO A 1 121 ? -7.688  -23.109 28.393  1    28.155 ? 1129 PRO A HB2    1 c 
ATOM   1808 H HB3    . PRO A 1 121 ? -7.054  -21.511 28.798  1    28.135 ? 1129 PRO A HB3    1 c 
ATOM   1809 H HG2    . PRO A 1 121 ? -9.775  -22.418 29.115  1    27.754 ? 1129 PRO A HG2    1 c 
ATOM   1810 H HG3    . PRO A 1 121 ? -9.166  -20.778 29.391  1    27.754 ? 1129 PRO A HG3    1 c 
ATOM   1811 H HD2    . PRO A 1 121 ? -10.82  -21.741 27.168  1    28.536 ? 1129 PRO A HD2    1 c 
ATOM   1812 H HD3    . PRO A 1 121 ? -10.316 -20.072 27.512  1    28.51  ? 1129 PRO A HD3    1 c 
ATOM   1813 N N      . SER A 1 122 ? -8.523  -23.726 25.708  1    27.659 ? 1130 SER A N      1 ? 
ATOM   1814 C CA     . SER A 1 122 ? -8.424  -25.077 25.213  1    29.005 ? 1130 SER A CA     1 ? 
ATOM   1815 C C      . SER A 1 122 ? -7.995  -24.992 23.759  1    21.522 ? 1130 SER A C      1 ? 
ATOM   1816 O O      . SER A 1 122 ? -7.635  -26.032 23.218  1    24.104 ? 1130 SER A O      1 ? 
ATOM   1817 C CB     . SER A 1 122 ? -9.727  -25.842 25.388  1    33.12  ? 1130 SER A CB     1 ? 
ATOM   1818 O OG     . SER A 1 122 ? -10.747 -25.24  24.583  1    34.268 ? 1130 SER A OG     1 ? 
ATOM   1819 H H      D SER A 1 122 ? -9.461  -23.292 25.766  0.88 22.605 ? 1130 SER A H      1 ? 
ATOM   1820 H HA     . SER A 1 122 ? -7.64   -25.591 25.773  1    27.897 ? 1130 SER A HA     1 c 
ATOM   1821 H HB2    . SER A 1 122 ? -9.586  -26.882 25.086  1    32.445 ? 1130 SER A HB2    1 c 
ATOM   1822 H HB3    . SER A 1 122 ? -10.027 -25.82  26.437  1    32.445 ? 1130 SER A HB3    1 c 
ATOM   1823 H HG     . SER A 1 122 ? -11.536 -25.786 24.692  1    32.305 ? 1130 SER A HG     1 ? 
ATOM   1824 N N      . LYS A 1 123 ? -8.001  -23.782 23.148  1    20.076 ? 1131 LYS A N      1 ? 
ATOM   1825 C CA     . LYS A 1 123 ? -7.585  -23.657 21.743  1    22.9   ? 1131 LYS A CA     1 ? 
ATOM   1826 C C      . LYS A 1 123 ? -6.289  -22.848 21.597  1    24.18  ? 1131 LYS A C      1 ? 
ATOM   1827 O O      . LYS A 1 123 ? -5.905  -22.494 20.481  1    22.984 ? 1131 LYS A O      1 ? 
ATOM   1828 C CB     . LYS A 1 123 ? -8.637  -22.887 20.94   1    22.661 ? 1131 LYS A CB     1 ? 
ATOM   1829 C CG     . LYS A 1 123 ? -10.001 -23.571 20.937  1    23.42  ? 1131 LYS A CG     1 ? 
ATOM   1830 C CD     . LYS A 1 123 ? -11.071 -22.817 20.171  1    22.746 ? 1131 LYS A CD     1 ? 
ATOM   1831 C CE     . LYS A 1 123 ? -12.289 -23.719 19.982  1    23.793 ? 1131 LYS A CE     1 ? 
ATOM   1832 N NZ     . LYS A 1 123 ? -13.326 -23.051 19.17   1    21.853 ? 1131 LYS A NZ     1 ? 
ATOM   1833 H H      . LYS A 1 123 ? -8.325  -22.908 23.607  1    14.857 ? 1131 LYS A H      1 ? 
ATOM   1834 H HA     . LYS A 1 123 ? -7.442  -24.653 21.319  1    22.522 ? 1131 LYS A HA     1 c 
ATOM   1835 H HB2    . LYS A 1 123 ? -8.748  -21.886 21.362  1    22.877 ? 1131 LYS A HB2    1 c 
ATOM   1836 H HB3    . LYS A 1 123 ? -8.297  -22.782 19.908  1    22.878 ? 1131 LYS A HB3    1 c 
ATOM   1837 H HG2    . LYS A 1 123 ? -9.888  -24.566 20.502  1    23.101 ? 1131 LYS A HG2    1 c 
ATOM   1838 H HG3    . LYS A 1 123 ? -10.328 -23.697 21.972  1    23.091 ? 1131 LYS A HG3    1 c 
ATOM   1839 H HD2    . LYS A 1 123 ? -11.363 -21.924 20.728  1    23.116 ? 1131 LYS A HD2    1 c 
ATOM   1840 H HD3    . LYS A 1 123 ? -10.685 -22.517 19.195  1    23.116 ? 1131 LYS A HD3    1 c 
ATOM   1841 H HE2    . LYS A 1 123 ? -11.985 -24.641 19.482  1    23.185 ? 1131 LYS A HE2    1 c 
ATOM   1842 H HE3    . LYS A 1 123 ? -12.71  -23.982 20.954  1    23.149 ? 1131 LYS A HE3    1 c 
ATOM   1843 H HZ1    . LYS A 1 123 ? -12.994 -22.733 18.252  1    21.663 ? 1131 LYS A HZ1    1 ? 
ATOM   1844 H HZ2    . LYS A 1 123 ? -14.032 -23.759 19.008  1    20.731 ? 1131 LYS A HZ2    1 ? 
ATOM   1845 H HZ3    . LYS A 1 123 ? -13.638 -22.206 19.658  1    19.946 ? 1131 LYS A HZ3    1 ? 
ATOM   1846 N N      . ASN A 1 124 ? -5.642  -22.498 22.726  1    23.952 ? 1132 ASN A N      1 ? 
ATOM   1847 C CA     . ASN A 1 124 ? -4.306  -21.911 22.667  1    22.054 ? 1132 ASN A CA     1 ? 
ATOM   1848 C C      . ASN A 1 124 ? -3.285  -22.96  22.212  1    18.811 ? 1132 ASN A C      1 ? 
ATOM   1849 O O      . ASN A 1 124 ? -3.474  -24.151 22.435  1    19.392 ? 1132 ASN A O      1 ? 
ATOM   1850 C CB     . ASN A 1 124 ? -3.9    -21.382 24.033  1    24.061 ? 1132 ASN A CB     1 ? 
ATOM   1851 C CG     . ASN A 1 124 ? -4.441  -19.999 24.27   1    28.594 ? 1132 ASN A CG     1 ? 
ATOM   1852 O OD1    . ASN A 1 124 ? -4.873  -19.309 23.335  1    30.769 ? 1132 ASN A OD1    1 ? 
ATOM   1853 N ND2    . ASN A 1 124 ? -4.359  -19.566 25.514  1    30.365 ? 1132 ASN A ND2    1 ? 
ATOM   1854 H H      . ASN A 1 124 ? -6.064  -22.683 23.653  1    20.097 ? 1132 ASN A H      1 ? 
ATOM   1855 H HA     . ASN A 1 124 ? -4.311  -21.079 21.96   1    22.176 ? 1132 ASN A HA     1 c 
ATOM   1856 H HB2    . ASN A 1 124 ? -4.276  -22.054 24.807  1    24.541 ? 1132 ASN A HB2    1 c 
ATOM   1857 H HB3    . ASN A 1 124 ? -2.811  -21.359 24.102  1    24.453 ? 1132 ASN A HB3    1 c 
ATOM   1858 H HD21   . ASN A 1 124 ? -4.546  -18.578 25.721  1    28.738 ? 1132 ASN A HD21   1 ? 
ATOM   1859 H HD22   . ASN A 1 124 ? -4.014  -20.232 26.207  1    27.629 ? 1132 ASN A HD22   1 ? 
ATOM   1860 N N      . GLY A 1 125 ? -2.158  -22.509 21.625  1    18.224 ? 1133 GLY A N      1 ? 
ATOM   1861 C CA     . GLY A 1 125 ? -1.06   -23.424 21.339  1    17.024 ? 1133 GLY A CA     1 ? 
ATOM   1862 C C      . GLY A 1 125 ? -0.483  -23.934 22.665  1    15.191 ? 1133 GLY A C      1 ? 
ATOM   1863 O O      . GLY A 1 125 ? -0.195  -23.125 23.554  1    16.356 ? 1133 GLY A O      1 ? 
ATOM   1864 H H      . GLY A 1 125 ? -2.018  -21.495 21.472  1    17.039 ? 1133 GLY A H      1 ? 
ATOM   1865 H HA2    . GLY A 1 125 ? -1.425  -24.26  20.74   1    16.857 ? 1133 GLY A HA2    1 c 
ATOM   1866 H HA3    . GLY A 1 125 ? -0.291  -22.899 20.772  1    16.842 ? 1133 GLY A HA3    1 c 
ATOM   1867 N N      . VAL A 1 126 ? -0.352  -25.243 22.794  1    14.51  ? 1134 VAL A N      1 ? 
ATOM   1868 C CA     . VAL A 1 126 ? 0.045   -25.89  24.037  1    16.075 ? 1134 VAL A CA     1 ? 
ATOM   1869 C C      . VAL A 1 126 ? 1.507   -25.554 24.361  1    15.612 ? 1134 VAL A C      1 ? 
ATOM   1870 O O      . VAL A 1 126 ? 1.799   -24.996 25.427  1    14.909 ? 1134 VAL A O      1 ? 
ATOM   1871 C CB     . VAL A 1 126 ? -0.222  -27.407 23.963  1    19.699 ? 1134 VAL A CB     1 ? 
ATOM   1872 C CG1    . VAL A 1 126 ? 0.467   -28.215 25.067  1    20.105 ? 1134 VAL A CG1    1 ? 
ATOM   1873 C CG2    . VAL A 1 126 ? -1.708  -27.723 23.908  1    21.27  ? 1134 VAL A CG2    1 ? 
ATOM   1874 H H      . VAL A 1 126 ? -0.627  -25.849 21.998  1    14.796 ? 1134 VAL A H      1 ? 
ATOM   1875 H HA     . VAL A 1 126 ? -0.577  -25.481 24.836  1    16.258 ? 1134 VAL A HA     1 c 
ATOM   1876 H HB     . VAL A 1 126 ? 0.204   -27.75  23.017  1    19.329 ? 1134 VAL A HB     1 c 
ATOM   1877 H HG11   . VAL A 1 126 ? 1.55    -28.152 24.946  1    19.889 ? 1134 VAL A HG11   1 c 
ATOM   1878 H HG12   . VAL A 1 126 ? 0.186   -27.813 26.043  1    19.953 ? 1134 VAL A HG12   1 c 
ATOM   1879 H HG13   . VAL A 1 126 ? 0.156   -29.26  25.002  1    19.896 ? 1134 VAL A HG13   1 c 
ATOM   1880 H HG21   . VAL A 1 126 ? -2.193  -27.351 24.812  1    20.831 ? 1134 VAL A HG21   1 c 
ATOM   1881 H HG22   . VAL A 1 126 ? -2.151  -27.242 23.034  1    20.865 ? 1134 VAL A HG22   1 c 
ATOM   1882 H HG23   . VAL A 1 126 ? -1.848  -28.804 23.838  1    20.829 ? 1134 VAL A HG23   1 c 
ATOM   1883 N N      . CYS A 1 127 ? 2.436   -25.869 23.443  1    15.246 ? 1135 CYS A N      1 ? 
ATOM   1884 C CA     . CYS A 1 127 ? 3.848   -25.816 23.805  1    14.165 ? 1135 CYS A CA     1 ? 
ATOM   1885 C C      . CYS A 1 127 ? 4.339   -24.365 23.838  1    13.952 ? 1135 CYS A C      1 ? 
ATOM   1886 O O      . CYS A 1 127 ? 5.169   -24.01  24.676  1    13.633 ? 1135 CYS A O      1 ? 
ATOM   1887 C CB     . CYS A 1 127 ? 4.669   -26.715 22.891  1    14.729 ? 1135 CYS A CB     1 ? 
ATOM   1888 S SG     . CYS A 1 127 ? 6.31    -27.086 23.558  1    14.038 ? 1135 CYS A SG     1 ? 
ATOM   1889 H H      . CYS A 1 127 ? 2.173   -26.185 22.498  1    15.193 ? 1135 CYS A H      1 ? 
ATOM   1890 H HA     . CYS A 1 127 ? 3.941   -26.222 24.814  1    14.429 ? 1135 CYS A HA     1 c 
ATOM   1891 H HB2    . CYS A 1 127 ? 4.135   -27.655 22.736  1    14.469 ? 1135 CYS A HB2    1 c 
ATOM   1892 H HB3    . CYS A 1 127 ? 4.788   -26.23  21.92   1    14.459 ? 1135 CYS A HB3    1 c 
ATOM   1893 H HG     . CYS A 1 127 ? 6.76    -25.839 23.772  1    14.186 ? 1135 CYS A HG     1 ? 
ATOM   1894 N N      . SER A 1 128 ? 3.831   -23.515 22.946  1    12.621 ? 1136 SER A N      1 ? 
ATOM   1895 C CA     . SER A 1 128 ? 4.295   -22.138 22.913  1    13.013 ? 1136 SER A CA     1 ? 
ATOM   1896 C C      . SER A 1 128 ? 3.886   -21.381 24.186  1    13.963 ? 1136 SER A C      1 ? 
ATOM   1897 O O      . SER A 1 128 ? 4.678   -20.62  24.762  1    14.249 ? 1136 SER A O      1 ? 
ATOM   1898 C CB     . SER A 1 128 ? 3.856   -21.417 21.647  1    12.797 ? 1136 SER A CB     1 ? 
ATOM   1899 O OG     . SER A 1 128 ? 2.443   -21.316 21.57   1    13.43  ? 1136 SER A OG     1 ? 
ATOM   1900 H H      . SER A 1 128 ? 3.117   -23.829 22.266  1    13.035 ? 1136 SER A H      1 ? 
ATOM   1901 H HA     . SER A 1 128 ? 5.386   -22.172 22.901  1    13.065 ? 1136 SER A HA     1 c 
ATOM   1902 H HB2    . SER A 1 128 ? 4.292   -20.418 21.637  1    13.012 ? 1136 SER A HB2    1 c 
ATOM   1903 H HB3    . SER A 1 128 ? 4.229   -21.96  20.776  1    12.993 ? 1136 SER A HB3    1 c 
ATOM   1904 H HG     . SER A 1 128 ? 2.141   -22.132 21.142  1    14.045 ? 1136 SER A HG     1 ? 
ATOM   1905 N N      . ASN A 1 129 ? 2.656   -21.606 24.643  1    13.423 ? 1137 ASN A N      1 ? 
ATOM   1906 C CA     . ASN A 1 129 ? 2.216   -21.016 25.904  1    14.86  ? 1137 ASN A CA     1 ? 
ATOM   1907 C C      . ASN A 1 129 ? 2.961   -21.624 27.09   1    13.273 ? 1137 ASN A C      1 ? 
ATOM   1908 O O      . ASN A 1 129 ? 3.359   -20.909 28.014  1    13.803 ? 1137 ASN A O      1 ? 
ATOM   1909 C CB     . ASN A 1 129 ? 0.704   -21.193 26.05   1    16.983 ? 1137 ASN A CB     1 ? 
ATOM   1910 C CG     . ASN A 1 129 ? -0.04   -20.144 25.261  1    16.415 ? 1137 ASN A CG     1 ? 
ATOM   1911 O OD1    . ASN A 1 129 ? -0.207  -19.024 25.745  1    18.539 ? 1137 ASN A OD1    1 ? 
ATOM   1912 N ND2    . ASN A 1 129 ? -0.381  -20.453 24.012  1    18.364 ? 1137 ASN A ND2    1 ? 
ATOM   1913 H H      . ASN A 1 129 ? 2.046   -22.293 24.17   1    13.613 ? 1137 ASN A H      1 ? 
ATOM   1914 H HA     . ASN A 1 129 ? 2.423   -19.944 25.873  1    14.633 ? 1137 ASN A HA     1 c 
ATOM   1915 H HB2    . ASN A 1 129 ? 0.418   -22.185 25.697  1    16.394 ? 1137 ASN A HB2    1 c 
ATOM   1916 H HB3    . ASN A 1 129 ? 0.43    -21.114 27.105  1    16.467 ? 1137 ASN A HB3    1 c 
ATOM   1917 H HD21   . ASN A 1 129 ? -0.87   -19.728 23.467  1    18.977 ? 1137 ASN A HD21   1 ? 
ATOM   1918 H HD22   . ASN A 1 129 ? -0.224  -21.323 23.513  1    17.148 ? 1137 ASN A HD22   1 ? 
ATOM   1919 N N      . PHE A 1 130 ? 3.158   -22.942 27.075  1    12.946 ? 1138 PHE A N      1 ? 
ATOM   1920 C CA     . PHE A 1 130 ? 3.917   -23.604 28.125  1    12.705 ? 1138 PHE A CA     1 ? 
ATOM   1921 C C      . PHE A 1 130 ? 5.29    -22.943 28.28   1    13.813 ? 1138 PHE A C      1 ? 
ATOM   1922 O O      . PHE A 1 130 ? 5.717   -22.603 29.393  1    11.437 ? 1138 PHE A O      1 ? 
ATOM   1923 C CB     . PHE A 1 130 ? 4.06    -25.083 27.781  1    13.124 ? 1138 PHE A CB     1 ? 
ATOM   1924 C CG     . PHE A 1 130 ? 5.054   -25.834 28.634  1    13.16  ? 1138 PHE A CG     1 ? 
ATOM   1925 C CD1    . PHE A 1 130 ? 4.835   -25.993 30.001  1    13.844 ? 1138 PHE A CD1    1 ? 
ATOM   1926 C CD2    . PHE A 1 130 ? 6.175   -26.401 28.066  1    12.889 ? 1138 PHE A CD2    1 ? 
ATOM   1927 C CE1    . PHE A 1 130 ? 5.732   -26.699 30.78   1    13.316 ? 1138 PHE A CE1    1 ? 
ATOM   1928 C CE2    . PHE A 1 130 ? 7.07    -27.111 28.839  1    13.708 ? 1138 PHE A CE2    1 ? 
ATOM   1929 C CZ     . PHE A 1 130 ? 6.858   -27.263 30.205  1    14.686 ? 1138 PHE A CZ     1 ? 
ATOM   1930 H H      . PHE A 1 130 ? 2.805   -23.491 26.261  1    14.299 ? 1138 PHE A H      1 ? 
ATOM   1931 H HA     . PHE A 1 130 ? 3.37    -23.51  29.066  1    13.053 ? 1138 PHE A HA     1 c 
ATOM   1932 H HB2    . PHE A 1 130 ? 3.081   -25.556 27.884  1    13.04  ? 1138 PHE A HB2    1 c 
ATOM   1933 H HB3    . PHE A 1 130 ? 4.36    -25.167 26.736  1    13.043 ? 1138 PHE A HB3    1 c 
ATOM   1934 H HD1    . PHE A 1 130 ? 3.952   -25.556 30.457  1    13.577 ? 1138 PHE A HD1    1 c 
ATOM   1935 H HD2    . PHE A 1 130 ? 6.349   -26.293 27.001  1    13.142 ? 1138 PHE A HD2    1 c 
ATOM   1936 H HE1    . PHE A 1 130 ? 5.554   -26.809 31.844  1    13.714 ? 1138 PHE A HE1    1 c 
ATOM   1937 H HE2    . PHE A 1 130 ? 7.952   -27.544 28.379  1    13.721 ? 1138 PHE A HE2    1 c 
ATOM   1938 H HZ     . PHE A 1 130 ? 7.568   -27.813 30.813  1    14.141 ? 1138 PHE A HZ     1 c 
ATOM   1939 N N      . LEU A 1 131 ? 5.988   -22.747 27.155  1    14.349 ? 1139 LEU A N      1 ? 
ATOM   1940 C CA     . LEU A 1 131 ? 7.317   -22.164 27.195  1    15.176 ? 1139 LEU A CA     1 ? 
ATOM   1941 C C      . LEU A 1 131 ? 7.268   -20.708 27.66   1    14.623 ? 1139 LEU A C      1 ? 
ATOM   1942 O O      . LEU A 1 131 ? 8.009   -20.305 28.575  1    13.88  ? 1139 LEU A O      1 ? 
ATOM   1943 C CB     . LEU A 1 131 ? 7.99    -22.297 25.835  1    15.282 ? 1139 LEU A CB     1 ? 
ATOM   1944 C CG     . LEU A 1 131 ? 8.42    -23.731 25.508  1    14.326 ? 1139 LEU A CG     1 ? 
ATOM   1945 C CD1    . LEU A 1 131 ? 8.794   -23.892 24.038  1    13.413 ? 1139 LEU A CD1    1 ? 
ATOM   1946 C CD2    . LEU A 1 131 ? 9.531   -24.228 26.418  1    14.928 ? 1139 LEU A CD2    1 ? 
ATOM   1947 H H      . LEU A 1 131 ? 5.521   -22.905 26.244  1    13.084 ? 1139 LEU A H      1 ? 
ATOM   1948 H HA     . LEU A 1 131 ? 7.899   -22.724 27.928  1    14.933 ? 1139 LEU A HA     1 c 
ATOM   1949 H HB2    . LEU A 1 131 ? 7.291   -21.957 25.068  1    15.046 ? 1139 LEU A HB2    1 c 
ATOM   1950 H HB3    . LEU A 1 131 ? 8.872   -21.654 25.82   1    15.046 ? 1139 LEU A HB3    1 c 
ATOM   1951 H HG     . LEU A 1 131 ? 7.557   -24.376 25.686  1    14.429 ? 1139 LEU A HG     1 c 
ATOM   1952 H HD11   . LEU A 1 131 ? 9.093   -24.925 23.848  1    13.67  ? 1139 LEU A HD11   1 c 
ATOM   1953 H HD12   . LEU A 1 131 ? 7.934   -23.643 23.413  1    13.67  ? 1139 LEU A HD12   1 c 
ATOM   1954 H HD13   . LEU A 1 131 ? 9.623   -23.224 23.797  1    13.702 ? 1139 LEU A HD13   1 c 
ATOM   1955 H HD21   . LEU A 1 131 ? 9.173   -24.263 27.449  1    14.763 ? 1139 LEU A HD21   1 c 
ATOM   1956 H HD22   . LEU A 1 131 ? 9.836   -25.229 26.106  1    14.762 ? 1139 LEU A HD22   1 c 
ATOM   1957 H HD23   . LEU A 1 131 ? 10.386  -23.552 26.352  1    14.773 ? 1139 LEU A HD23   1 c 
ATOM   1958 N N      . CYS A 1 132 ? 6.377   -19.898 27.061  1    12.888 ? 1140 CYS A N      1 ? 
ATOM   1959 C CA     . CYS A 1 132 ? 6.335   -18.493 27.412  1    14.423 ? 1140 CYS A CA     1 ? 
ATOM   1960 C C      . CYS A 1 132 ? 5.849   -18.259 28.853  1    14.122 ? 1140 CYS A C      1 ? 
ATOM   1961 O O      . CYS A 1 132 ? 6.13    -17.203 29.421  1    11.816 ? 1140 CYS A O      1 ? 
ATOM   1962 C CB     . CYS A 1 132 ? 5.466   -17.71  26.441  1    16.496 ? 1140 CYS A CB     1 ? 
ATOM   1963 S SG     . CYS A 1 132 ? 6.186   -17.547 24.781  1    16.697 ? 1140 CYS A SG     1 ? 
ATOM   1964 H H      . CYS A 1 132 ? 5.635   -20.287 26.443  1    13.177 ? 1140 CYS A H      1 ? 
ATOM   1965 H HA     . CYS A 1 132 ? 7.352   -18.104 27.332  1    14.408 ? 1140 CYS A HA     1 c 
ATOM   1966 H HB2    . CYS A 1 132 ? 4.498   -18.206 26.35   1    16.033 ? 1140 CYS A HB2    1 c 
ATOM   1967 H HB3    . CYS A 1 132 ? 5.295   -16.709 26.843  1    16.033 ? 1140 CYS A HB3    1 c 
ATOM   1968 N N      . ASN A 1 133 ? 5.125   -19.22  29.432  1    12.398 ? 1141 ASN A N      1 ? 
ATOM   1969 C CA     . ASN A 1 133 ? 4.669   -19.158 30.813  1    14.828 ? 1141 ASN A CA     1 ? 
ATOM   1970 C C      . ASN A 1 133 ? 5.688   -19.72  31.806  1    12.908 ? 1141 ASN A C      1 ? 
ATOM   1971 O O      . ASN A 1 133 ? 5.443   -19.705 33.02   1    13.496 ? 1141 ASN A O      1 ? 
ATOM   1972 C CB     . ASN A 1 133 ? 3.36    -19.943 30.959  1    15.947 ? 1141 ASN A CB     1 ? 
ATOM   1973 C CG     . ASN A 1 133 ? 2.187   -19.224 30.331  1    15.408 ? 1141 ASN A CG     1 ? 
ATOM   1974 O OD1    . ASN A 1 133 ? 2.202   -18.002 30.171  1    14.555 ? 1141 ASN A OD1    1 ? 
ATOM   1975 N ND2    . ASN A 1 133 ? 1.159   -19.968 29.982  1    16.614 ? 1141 ASN A ND2    1 ? 
ATOM   1976 H H      . ASN A 1 133 ? 4.879   -20.056 28.873  1    13.18  ? 1141 ASN A H      1 ? 
ATOM   1977 H HA     . ASN A 1 133 ? 4.467   -18.116 31.068  1    14.159 ? 1141 ASN A HA     1 c 
ATOM   1978 H HB2    . ASN A 1 133 ? 3.474   -20.922 30.489  1    15.566 ? 1141 ASN A HB2    1 c 
ATOM   1979 H HB3    . ASN A 1 133 ? 3.153   -20.101 32.02   1    15.564 ? 1141 ASN A HB3    1 c 
ATOM   1980 H HD21   . ASN A 1 133 ? 0.3     -19.555 29.704  1    16.916 ? 1141 ASN A HD21   1 ? 
ATOM   1981 H HD22   . ASN A 1 133 ? 1.22    -20.946 30.204  1    16.93  ? 1141 ASN A HD22   1 ? 
ATOM   1982 N N      . SER A 1 134 ? 6.81    -20.236 31.32   1    12.433 ? 1142 SER A N      1 ? 
ATOM   1983 C CA     . SER A 1 134 ? 7.772   -20.895 32.194  1    12.836 ? 1142 SER A CA     1 ? 
ATOM   1984 C C      . SER A 1 134 ? 8.519   -19.882 33.063  1    13.275 ? 1142 SER A C      1 ? 
ATOM   1985 O O      . SER A 1 134 ? 8.601   -18.684 32.755  1    13.072 ? 1142 SER A O      1 ? 
ATOM   1986 C CB     . SER A 1 134 ? 8.747   -21.738 31.387  1    12.196 ? 1142 SER A CB     1 ? 
ATOM   1987 O OG     . SER A 1 134 ? 8.113   -22.868 30.801  1    12.436 ? 1142 SER A OG     1 ? 
ATOM   1988 H H      . SER A 1 134 ? 6.989   -20.218 30.299  1    12.637 ? 1142 SER A H      1 ? 
ATOM   1989 H HA     . SER A 1 134 ? 7.217   -21.562 32.858  1    12.723 ? 1142 SER A HA     1 c 
ATOM   1990 H HB2    . SER A 1 134 ? 9.19    -21.122 30.602  1    12.417 ? 1142 SER A HB2    1 c 
ATOM   1991 H HB3    . SER A 1 134 ? 9.553   -22.077 32.042  1    12.399 ? 1142 SER A HB3    1 c 
ATOM   1992 H HG     . SER A 1 134 ? 7.34    -22.613 30.27   1    12.864 ? 1142 SER A HG     1 ? 
ATOM   1993 N N      . LYS A 1 135 ? 9.073   -20.385 34.156  1    13.796 ? 1143 LYS A N      1 ? 
ATOM   1994 C CA     . LYS A 1 135 ? 9.791   -19.586 35.124  1    14.706 ? 1143 LYS A CA     1 ? 
ATOM   1995 C C      . LYS A 1 135 ? 11.095  -20.274 35.488  1    14.433 ? 1143 LYS A C      1 ? 
ATOM   1996 O O      . LYS A 1 135 ? 11.215  -21.499 35.373  1    13.439 ? 1143 LYS A O      1 ? 
ATOM   1997 C CB     . LYS A 1 135 ? 8.966   -19.392 36.4    1    15.177 ? 1143 LYS A CB     1 ? 
ATOM   1998 C CG     . LYS A 1 135 ? 7.65    -18.683 36.168  1    16.749 ? 1143 LYS A CG     1 ? 
ATOM   1999 C CD     . LYS A 1 135 ? 7.88    -17.215 35.857  1    19.988 ? 1143 LYS A CD     1 ? 
ATOM   2000 C CE     . LYS A 1 135 ? 6.567   -16.514 35.628  1    26.507 ? 1143 LYS A CE     1 ? 
ATOM   2001 N NZ     . LYS A 1 135 ? 6.674   -15.044 35.467  1    27.878 ? 1143 LYS A NZ     1 ? 
ATOM   2002 H H      . LYS A 1 135 ? 9       -21.404 34.313  1    13.934 ? 1143 LYS A H      1 ? 
ATOM   2003 H HA     . LYS A 1 135 ? 10.011  -18.615 34.679  1    14.591 ? 1143 LYS A HA     1 c 
ATOM   2004 H HB2    . LYS A 1 135 ? 8.763   -20.369 36.844  1    15.405 ? 1143 LYS A HB2    1 c 
ATOM   2005 H HB3    . LYS A 1 135 ? 9.553   -18.813 37.117  1    15.404 ? 1143 LYS A HB3    1 c 
ATOM   2006 H HG2    . LYS A 1 135 ? 7.128   -19.157 35.335  1    16.992 ? 1143 LYS A HG2    1 c 
ATOM   2007 H HG3    . LYS A 1 135 ? 7.032   -18.774 37.064  1    17.025 ? 1143 LYS A HG3    1 c 
ATOM   2008 H HD2    . LYS A 1 135 ? 8.401   -16.742 36.692  1    20.456 ? 1143 LYS A HD2    1 c 
ATOM   2009 H HD3    . LYS A 1 135 ? 8.499   -17.123 34.962  1    20.383 ? 1143 LYS A HD3    1 c 
ATOM   2010 H HE2    . LYS A 1 135 ? 6.104   -16.931 34.732  1    25.276 ? 1143 LYS A HE2    1 c 
ATOM   2011 H HE3    . LYS A 1 135 ? 5.904   -16.724 36.469  1    25.206 ? 1143 LYS A HE3    1 c 
ATOM   2012 H HZ1    . LYS A 1 135 ? 7.195   -14.835 34.606  1    26.055 ? 1143 LYS A HZ1    1 ? 
ATOM   2013 H HZ2    . LYS A 1 135 ? 5.739   -14.644 35.382  1    26.185 ? 1143 LYS A HZ2    1 ? 
ATOM   2014 H HZ3    . LYS A 1 135 ? 7.154   -14.587 36.256  1    26.672 ? 1143 LYS A HZ3    1 ? 
ATOM   2015 N N      . PRO A 1 136 ? 12.075  -19.515 35.997  1    14.642 ? 1144 PRO A N      1 ? 
ATOM   2016 C CA     . PRO A 1 136 ? 13.319  -20.13  36.437  1    14.97  ? 1144 PRO A CA     1 ? 
ATOM   2017 C C      . PRO A 1 136 ? 13.076  -21.315 37.358  1    12.93  ? 1144 PRO A C      1 ? 
ATOM   2018 O O      . PRO A 1 136 ? 12.256  -21.253 38.279  1    12.408 ? 1144 PRO A O      1 ? 
ATOM   2019 C CB     . PRO A 1 136 ? 14.039  -18.988 37.164  1    15.214 ? 1144 PRO A CB     1 ? 
ATOM   2020 C CG     . PRO A 1 136 ? 13.524  -17.758 36.462  1    16.213 ? 1144 PRO A CG     1 ? 
ATOM   2021 C CD     . PRO A 1 136 ? 12.083  -18.057 36.157  1    15.158 ? 1144 PRO A CD     1 ? 
ATOM   2022 H HA     . PRO A 1 136 ? 13.9    -20.447 35.569  1    14.551 ? 1144 PRO A HA     1 c 
ATOM   2023 H HB2    . PRO A 1 136 ? 13.778  -18.972 38.225  1    15.373 ? 1144 PRO A HB2    1 c 
ATOM   2024 H HB3    . PRO A 1 136 ? 15.122  -19.076 37.059  1    15.373 ? 1144 PRO A HB3    1 c 
ATOM   2025 H HG2    . PRO A 1 136 ? 13.607  -16.879 37.105  1    15.757 ? 1144 PRO A HG2    1 c 
ATOM   2026 H HG3    . PRO A 1 136 ? 14.081  -17.575 35.541  1    15.754 ? 1144 PRO A HG3    1 c 
ATOM   2027 H HD2    . PRO A 1 136 ? 11.43   -17.753 36.978  1    15.273 ? 1144 PRO A HD2    1 c 
ATOM   2028 H HD3    . PRO A 1 136 ? 11.762  -17.566 35.238  1    15.318 ? 1144 PRO A HD3    1 c 
ATOM   2029 N N      . GLY A 1 137 ? 13.798  -22.409 37.095  1    13.076 ? 1145 GLY A N      1 ? 
ATOM   2030 C CA     . GLY A 1 137 ? 13.689  -23.596 37.892  1    13.973 ? 1145 GLY A CA     1 ? 
ATOM   2031 C C      . GLY A 1 137 ? 12.681  -24.613 37.351  1    15.628 ? 1145 GLY A C      1 ? 
ATOM   2032 O O      . GLY A 1 137 ? 12.743  -25.783 37.74   1    16.459 ? 1145 GLY A O      1 ? 
ATOM   2033 H H      . GLY A 1 137 ? 14.392  -22.444 36.256  1    14.06  ? 1145 GLY A H      1 ? 
ATOM   2034 H HA2    . GLY A 1 137 ? 14.672  -24.068 37.943  1    14.101 ? 1145 GLY A HA2    1 c 
ATOM   2035 H HA3    . GLY A 1 137 ? 13.408  -23.318 38.909  1    14.137 ? 1145 GLY A HA3    1 c 
ATOM   2036 N N      . ASP A 1 138 ? 11.766  -24.202 36.466  1    15.672 ? 1146 ASP A N      1 ? 
ATOM   2037 C CA     . ASP A 1 138 ? 10.85   -25.158 35.882  1    15.47  ? 1146 ASP A CA     1 ? 
ATOM   2038 C C      . ASP A 1 138 ? 11.61   -26.189 35.049  1    15.48  ? 1146 ASP A C      1 ? 
ATOM   2039 O O      . ASP A 1 138 ? 12.655  -25.895 34.458  1    14.694 ? 1146 ASP A O      1 ? 
ATOM   2040 C CB     . ASP A 1 138 ? 9.843   -24.461 34.985  1    14.281 ? 1146 ASP A CB     1 ? 
ATOM   2041 C CG     . ASP A 1 138 ? 8.755   -23.696 35.706  1    14.866 ? 1146 ASP A CG     1 ? 
ATOM   2042 O OD1    . ASP A 1 138 ? 8.589   -23.852 36.943  1    14.692 ? 1146 ASP A OD1    1 ? 
ATOM   2043 O OD2    . ASP A 1 138 ? 8.036   -22.951 35.001  1    13.864 ? 1146 ASP A OD2    1 ? 
ATOM   2044 H H      . ASP A 1 138 ? 11.684  -23.203 36.203  1    15.857 ? 1146 ASP A H      1 ? 
ATOM   2045 H HA     . ASP A 1 138 ? 10.321  -25.672 36.688  1    15.288 ? 1146 ASP A HA     1 c 
ATOM   2046 H HB2    . ASP A 1 138 ? 10.378  -23.761 34.34   1    14.648 ? 1146 ASP A HB2    1 c 
ATOM   2047 H HB3    . ASP A 1 138 ? 9.368   -25.208 34.345  1    14.588 ? 1146 ASP A HB3    1 c 
ATOM   2048 N N      . LYS A 1 139 ? 11.054  -27.395 34.957  1    13.864 ? 1147 LYS A N      1 ? 
ATOM   2049 C CA     . LYS A 1 139 ? 11.642  -28.472 34.181  1    14.82  ? 1147 LYS A CA     1 ? 
ATOM   2050 C C      . LYS A 1 139 ? 10.978  -28.569 32.81   1    16.191 ? 1147 LYS A C      1 ? 
ATOM   2051 O O      . LYS A 1 139 ? 9.756   -28.352 32.667  1    13.797 ? 1147 LYS A O      1 ? 
ATOM   2052 C CB     . LYS A 1 139 ? 11.536  -29.825 34.887  1    15.503 ? 1147 LYS A CB     1 ? 
ATOM   2053 C CG     . LYS A 1 139 ? 12.079  -29.79  36.305  1    16.733 ? 1147 LYS A CG     1 ? 
ATOM   2054 C CD     . LYS A 1 139 ? 13.447  -29.144 36.397  1    18.503 ? 1147 LYS A CD     1 ? 
ATOM   2055 C CE     . LYS A 1 139 ? 14.089  -29.438 37.704  1    23.598 ? 1147 LYS A CE     1 ? 
ATOM   2056 N NZ     . LYS A 1 139 ? 15.442  -28.853 37.801  1    26.445 ? 1147 LYS A NZ     1 ? 
ATOM   2057 H H      . LYS A 1 139 ? 10.19   -27.549 35.478  1    14.151 ? 1147 LYS A H      1 ? 
ATOM   2058 H HA     . LYS A 1 139 ? 12.697  -28.245 34.033  1    14.985 ? 1147 LYS A HA     1 c 
ATOM   2059 H HB2    . LYS A 1 139 ? 10.489  -30.132 34.919  1    15.613 ? 1147 LYS A HB2    1 c 
ATOM   2060 H HB3    . LYS A 1 139 ? 12.091  -30.572 34.316  1    15.615 ? 1147 LYS A HB3    1 c 
ATOM   2061 H HG2    . LYS A 1 139 ? 11.379  -29.238 36.935  1    16.82  ? 1147 LYS A HG2    1 c 
ATOM   2062 H HG3    . LYS A 1 139 ? 12.14   -30.813 36.683  1    16.82  ? 1147 LYS A HG3    1 c 
ATOM   2063 H HD2    . LYS A 1 139 ? 14.081  -29.52  35.592  1    19.107 ? 1147 LYS A HD2    1 c 
ATOM   2064 H HD3    . LYS A 1 139 ? 13.346  -28.062 36.282  1    19.073 ? 1147 LYS A HD3    1 c 
ATOM   2065 H HE2    . LYS A 1 139 ? 13.471  -29.009 38.494  1    22.98  ? 1147 LYS A HE2    1 c 
ATOM   2066 H HE3    . LYS A 1 139 ? 14.132  -30.513 37.866  1    23.195 ? 1147 LYS A HE3    1 c 
ATOM   2067 H HZ1    . LYS A 1 139 ? 15.955  -29.122 36.97   1    25.428 ? 1147 LYS A HZ1    1 ? 
ATOM   2068 H HZ2    . LYS A 1 139 ? 15.433  -27.836 37.901  1    25.246 ? 1147 LYS A HZ2    1 ? 
ATOM   2069 H HZ3    . LYS A 1 139 ? 15.883  -29.246 38.624  1    24.963 ? 1147 LYS A HZ3    1 ? 
ATOM   2070 N N      . ILE A 1 140 ? 11.781  -28.891 31.795  1    17.494 ? 1148 ILE A N      1 ? 
ATOM   2071 C CA     . ILE A 1 140 ? 11.199  -29.14  30.495  1    18.265 ? 1148 ILE A CA     1 ? 
ATOM   2072 C C      . ILE A 1 140 ? 11.809  -30.417 29.949  1    18.573 ? 1148 ILE A C      1 ? 
ATOM   2073 O O      . ILE A 1 140 ? 13.006  -30.666 30.172  1    16.042 ? 1148 ILE A O      1 ? 
ATOM   2074 C CB     . ILE A 1 140 ? 11.339  -27.961 29.517  1    20.309 ? 1148 ILE A CB     1 ? 
ATOM   2075 C CG1    . ILE A 1 140 ? 12.718  -27.892 28.966  1    23.33  ? 1148 ILE A CG1    1 ? 
ATOM   2076 C CG2    . ILE A 1 140 ? 10.844  -26.616 30.114  1    19.921 ? 1148 ILE A CG2    1 ? 
ATOM   2077 C CD1    . ILE A 1 140 ? 12.863  -26.887 27.833  1    25.227 ? 1148 ILE A CD1    1 ? 
ATOM   2078 H H      . ILE A 1 140 ? 12.811  -28.87  31.909  1    16.506 ? 1148 ILE A H      1 ? 
ATOM   2079 H HA     . ILE A 1 140 ? 10.132  -29.321 30.637  1    18.461 ? 1148 ILE A HA     1 c 
ATOM   2080 H HB     . ILE A 1 140 ? 10.683  -28.185 28.673  1    20.379 ? 1148 ILE A HB     1 c 
ATOM   2081 H HG12   . ILE A 1 140 ? 13.407  -27.623 29.769  1    22.991 ? 1148 ILE A HG12   1 c 
ATOM   2082 H HG13   . ILE A 1 140 ? 13.005  -28.877 28.592  1    22.923 ? 1148 ILE A HG13   1 c 
ATOM   2083 H HG21   . ILE A 1 140 ? 10.904  -25.832 29.355  1    20.076 ? 1148 ILE A HG21   1 c 
ATOM   2084 H HG22   . ILE A 1 140 ? 9.808   -26.721 30.443  1    20.03  ? 1148 ILE A HG22   1 c 
ATOM   2085 H HG23   . ILE A 1 140 ? 11.468  -26.343 30.967  1    19.993 ? 1148 ILE A HG23   1 c 
ATOM   2086 H HD11   . ILE A 1 140 ? 12.666  -25.878 28.201  1    24.542 ? 1148 ILE A HD11   1 c 
ATOM   2087 H HD12   . ILE A 1 140 ? 13.881  -26.937 27.443  1    24.471 ? 1148 ILE A HD12   1 c 
ATOM   2088 H HD13   . ILE A 1 140 ? 12.158  -27.127 27.035  1    24.495 ? 1148 ILE A HD13   1 c 
ATOM   2089 N N      . GLN A 1 141 ? 10.982  -31.152 29.18   1    16.5   ? 1149 GLN A N      1 ? 
ATOM   2090 C CA     . GLN A 1 141 ? 11.407  -32.389 28.526  1    17.721 ? 1149 GLN A CA     1 ? 
ATOM   2091 C C      . GLN A 1 141 ? 11.963  -32.04  27.143  1    15.556 ? 1149 GLN A C      1 ? 
ATOM   2092 O O      . GLN A 1 141 ? 11.206  -31.627 26.267  1    15.178 ? 1149 GLN A O      1 ? 
ATOM   2093 C CB     . GLN A 1 141 ? 10.266  -33.41  28.419  1    18.723 ? 1149 GLN A CB     1 ? 
ATOM   2094 C CG     . GLN A 1 141 ? 9.624   -33.841 29.736  1    19.983 ? 1149 GLN A CG     1 ? 
ATOM   2095 C CD     . GLN A 1 141 ? 10.566  -34.615 30.638  1    26.569 ? 1149 GLN A CD     1 ? 
ATOM   2096 O OE1    . GLN A 1 141 ? 11.076  -34.093 31.655  1    23.243 ? 1149 GLN A OE1    1 ? 
ATOM   2097 N NE2    . GLN A 1 141 ? 10.742  -35.904 30.317  1    27.863 ? 1149 GLN A NE2    1 ? 
ATOM   2098 H H      . GLN A 1 141 ? 10.052  -30.764 28.956  1    16.062 ? 1149 GLN A H      1 ? 
ATOM   2099 H HA     . GLN A 1 141 ? 12.21   -32.83  29.121  1    17.224 ? 1149 GLN A HA     1 c 
ATOM   2100 H HB2    . GLN A 1 141 ? 9.49    -32.986 27.778  1    18.765 ? 1149 GLN A HB2    1 c 
ATOM   2101 H HB3    . GLN A 1 141 ? 10.652  -34.299 27.915  1    18.765 ? 1149 GLN A HB3    1 c 
ATOM   2102 H HG2    . GLN A 1 141 ? 9.273   -32.956 30.271  1    21.016 ? 1149 GLN A HG2    1 c 
ATOM   2103 H HG3    . GLN A 1 141 ? 8.756   -34.466 29.524  1    21.15  ? 1149 GLN A HG3    1 c 
ATOM   2104 H HE21   . GLN A 1 141 ? 10.267  -36.3   29.51   1    26.566 ? 1149 GLN A HE21   1 ? 
ATOM   2105 H HE22   . GLN A 1 141 ? 11.307  -36.513 30.905  1    25.544 ? 1149 GLN A HE22   1 ? 
ATOM   2106 N N      . LEU A 1 142 ? 13.284  -32.219 26.959  1    15.508 ? 1150 LEU A N      1 ? 
ATOM   2107 C CA     . LEU A 1 142 ? 14.012  -31.777 25.765  1    16.598 ? 1150 LEU A CA     1 ? 
ATOM   2108 C C      . LEU A 1 142 ? 14.392  -32.987 24.908  1    15.936 ? 1150 LEU A C      1 ? 
ATOM   2109 O O      . LEU A 1 142 ? 14.779  -34.028 25.448  1    13.89  ? 1150 LEU A O      1 ? 
ATOM   2110 C CB     . LEU A 1 142 ? 15.258  -31.037 26.257  1    17.392 ? 1150 LEU A CB     1 ? 
ATOM   2111 C CG     . LEU A 1 142 ? 15.864  -29.945 25.356  1    18.803 ? 1150 LEU A CG     1 ? 
ATOM   2112 C CD1    . LEU A 1 142 ? 14.897  -28.805 25.027  1    20.213 ? 1150 LEU A CD1    1 ? 
ATOM   2113 C CD2    . LEU A 1 142 ? 17.067  -29.393 26.076  1    17.749 ? 1150 LEU A CD2    1 ? 
ATOM   2114 H H      . LEU A 1 142 ? 13.842  -32.684 27.703  1    14.815 ? 1150 LEU A H      1 ? 
ATOM   2115 H HA     . LEU A 1 142 ? 13.38   -31.1   25.189  1    16.428 ? 1150 LEU A HA     1 c 
ATOM   2116 H HB2    . LEU A 1 142 ? 15.017  -30.585 27.221  1    17.509 ? 1150 LEU A HB2    1 c 
ATOM   2117 H HB3    . LEU A 1 142 ? 16.032  -31.782 26.452  1    17.509 ? 1150 LEU A HB3    1 c 
ATOM   2118 H HG     . LEU A 1 142 ? 16.194  -30.406 24.423  1    18.589 ? 1150 LEU A HG     1 c 
ATOM   2119 H HD11   . LEU A 1 142 ? 15.402  -28.069 24.398  1    19.787 ? 1150 LEU A HD11   1 c 
ATOM   2120 H HD12   . LEU A 1 142 ? 14.03   -29.202 24.496  1    19.733 ? 1150 LEU A HD12   1 c 
ATOM   2121 H HD13   . LEU A 1 142 ? 14.569  -28.327 25.952  1    19.762 ? 1150 LEU A HD13   1 c 
ATOM   2122 H HD21   . LEU A 1 142 ? 16.758  -28.971 27.034  1    18.035 ? 1150 LEU A HD21   1 c 
ATOM   2123 H HD22   . LEU A 1 142 ? 17.789  -30.194 26.248  1    18.035 ? 1150 LEU A HD22   1 c 
ATOM   2124 H HD23   . LEU A 1 142 ? 17.529  -28.612 25.468  1    18.026 ? 1150 LEU A HD23   1 c 
ATOM   2125 N N      . THR A 1 143 ? 14.219  -32.874 23.577  1    14.318 ? 1151 THR A N      1 ? 
ATOM   2126 C CA     . THR A 1 143 ? 14.657  -33.92  22.667  1    14.637 ? 1151 THR A CA     1 ? 
ATOM   2127 C C      . THR A 1 143 ? 15.52   -33.316 21.565  1    13.769 ? 1151 THR A C      1 ? 
ATOM   2128 O O      . THR A 1 143 ? 15.552  -32.098 21.36   1    12.261 ? 1151 THR A O      1 ? 
ATOM   2129 C CB     . THR A 1 143 ? 13.474  -34.682 22.057  1    15.188 ? 1151 THR A CB     1 ? 
ATOM   2130 O OG1    . THR A 1 143 ? 12.728  -33.799 21.209  1    15.827 ? 1151 THR A OG1    1 ? 
ATOM   2131 C CG2    . THR A 1 143 ? 12.551  -35.231 23.146  1    17.307 ? 1151 THR A CG2    1 ? 
ATOM   2132 H H      . THR A 1 143 ? 13.837  -31.992 23.182  1    14.855 ? 1151 THR A H      1 ? 
ATOM   2133 H HA     . THR A 1 143 ? 15.267  -34.63  23.23   1    14.517 ? 1151 THR A HA     1 c 
ATOM   2134 H HB     . THR A 1 143 ? 13.851  -35.517 21.462  1    15.565 ? 1151 THR A HB     1 c 
ATOM   2135 H HG1    . THR A 1 143 ? 12.961  -33.919 20.281  1    15.971 ? 1151 THR A HG1    1 ? 
ATOM   2136 H HG21   . THR A 1 143 ? 12.164  -34.406 23.747  1    16.673 ? 1151 THR A HG21   1 c 
ATOM   2137 H HG22   . THR A 1 143 ? 11.718  -35.763 22.682  1    16.719 ? 1151 THR A HG22   1 c 
ATOM   2138 H HG23   . THR A 1 143 ? 13.109  -35.917 23.786  1    16.639 ? 1151 THR A HG23   1 c 
ATOM   2139 N N      . GLY A 1 144 ? 16.209  -34.197 20.854  1    13.766 ? 1152 GLY A N      1 ? 
ATOM   2140 C CA     . GLY A 1 144 ? 17.029  -33.79  19.738  1    14.135 ? 1152 GLY A CA     1 ? 
ATOM   2141 C C      . GLY A 1 144 ? 18.499  -33.758 20.124  1    15.984 ? 1152 GLY A C      1 ? 
ATOM   2142 O O      . GLY A 1 144 ? 18.968  -34.593 20.906  1    17.796 ? 1152 GLY A O      1 ? 
ATOM   2143 H H      . GLY A 1 144 ? 16.154  -35.198 21.104  1    13.197 ? 1152 GLY A H      1 ? 
ATOM   2144 H HA2    . GLY A 1 144 ? 16.885  -34.496 18.918  1    14.434 ? 1152 GLY A HA2    1 c 
ATOM   2145 H HA3    . GLY A 1 144 ? 16.709  -32.808 19.391  1    14.47  ? 1152 GLY A HA3    1 c 
ATOM   2146 N N      . PRO A 1 145 ? 19.27   -32.803 19.563  1    15.244 ? 1153 PRO A N      1 ? 
ATOM   2147 C CA     . PRO A 1 145 ? 18.784  -31.82  18.598  1    14.741 ? 1153 PRO A CA     1 ? 
ATOM   2148 C C      . PRO A 1 145 ? 18.486  -32.501 17.267  1    14.785 ? 1153 PRO A C      1 ? 
ATOM   2149 O O      . PRO A 1 145 ? 18.761  -33.694 17.078  1    12.98  ? 1153 PRO A O      1 ? 
ATOM   2150 C CB     . PRO A 1 145 ? 19.966  -30.85  18.465  1    15.311 ? 1153 PRO A CB     1 ? 
ATOM   2151 C CG     . PRO A 1 145 ? 21.157  -31.721 18.726  1    15.147 ? 1153 PRO A CG     1 ? 
ATOM   2152 C CD     . PRO A 1 145 ? 20.728  -32.758 19.729  1    14.12  ? 1153 PRO A CD     1 ? 
ATOM   2153 H HA     . PRO A 1 145 ? 17.898  -31.311 18.981  1    14.917 ? 1153 PRO A HA     1 c 
ATOM   2154 H HB2    . PRO A 1 145 ? 20.007  -30.418 17.463  1    15.152 ? 1153 PRO A HB2    1 c 
ATOM   2155 H HB3    . PRO A 1 145 ? 19.898  -30.046 19.201  1    15.152 ? 1153 PRO A HB3    1 c 
ATOM   2156 H HG2    . PRO A 1 145 ? 21.488  -32.201 17.805  1    14.959 ? 1153 PRO A HG2    1 c 
ATOM   2157 H HG3    . PRO A 1 145 ? 21.983  -31.129 19.123  1    14.946 ? 1153 PRO A HG3    1 c 
ATOM   2158 H HD2    . PRO A 1 145 ? 21.172  -33.731 19.51   1    14.578 ? 1153 PRO A HD2    1 c 
ATOM   2159 H HD3    . PRO A 1 145 ? 20.992  -32.461 20.746  1    14.565 ? 1153 PRO A HD3    1 c 
ATOM   2160 N N      . SER A 1 146 ? 17.922  -31.752 16.33   1    14.575 ? 1154 SER A N      1 ? 
ATOM   2161 C CA     . SER A 1 146 ? 17.728  -32.327 15.014  1    16.046 ? 1154 SER A CA     1 ? 
ATOM   2162 C C      . SER A 1 146 ? 17.832  -31.244 13.964  1    15.881 ? 1154 SER A C      1 ? 
ATOM   2163 O O      . SER A 1 146 ? 17.818  -30.044 14.26   1    16.131 ? 1154 SER A O      1 ? 
ATOM   2164 C CB     . SER A 1 146 ? 16.399  -33.066 14.901  1    17.322 ? 1154 SER A CB     1 ? 
ATOM   2165 O OG     . SER A 1 146 ? 15.329  -32.17  15.115  1    16.584 ? 1154 SER A OG     1 ? 
ATOM   2166 H H      . SER A 1 146 ? 17.538  -30.823 16.56   1    15.506 ? 1154 SER A H      1 ? 
ATOM   2167 H HA     . SER A 1 146 ? 18.533  -33.043 14.836  1    15.913 ? 1154 SER A HA     1 c 
ATOM   2168 H HB2    . SER A 1 146 ? 16.313  -33.511 13.907  1    16.87  ? 1154 SER A HB2    1 c 
ATOM   2169 H HB3    . SER A 1 146 ? 16.362  -33.866 15.643  1    16.87  ? 1154 SER A HB3    1 c 
ATOM   2170 H HG     . SER A 1 146 ? 15.073  -32.318 16.05   1    16.147 ? 1154 SER A HG     1 ? 
ATOM   2171 N N      . GLY A 1 147 ? 17.932  -31.701 12.726  1    17.299 ? 1155 GLY A N      1 ? 
ATOM   2172 C CA     . GLY A 1 147 ? 17.965  -30.813 11.588  1    15.918 ? 1155 GLY A CA     1 ? 
ATOM   2173 C C      . GLY A 1 147 ? 19.368  -30.589 11.068  1    16.884 ? 1155 GLY A C      1 ? 
ATOM   2174 O O      . GLY A 1 147 ? 20.322  -30.469 11.825  1    16.745 ? 1155 GLY A O      1 ? 
ATOM   2175 H H      . GLY A 1 147 ? 17.915  -32.727 12.581  1    16.286 ? 1155 GLY A H      1 ? 
ATOM   2176 H HA2    . GLY A 1 147 ? 17.344  -31.231 10.793  1    16.435 ? 1155 GLY A HA2    1 c 
ATOM   2177 H HA3    . GLY A 1 147 ? 17.533  -29.853 11.881  1    16.436 ? 1155 GLY A HA3    1 c 
ATOM   2178 N N      . LYS A 1 148 ? 19.462  -30.557 9.738   1    15.798 ? 1156 LYS A N      1 ? 
ATOM   2179 C CA     . LYS A 1 148 ? 20.688  -30.203 9.052   1    18.37  ? 1156 LYS A CA     1 ? 
ATOM   2180 C C      . LYS A 1 148 ? 20.506  -29.116 7.991   1    18.916 ? 1156 LYS A C      1 ? 
ATOM   2181 O O      . LYS A 1 148 ? 21.508  -28.602 7.495   1    15.531 ? 1156 LYS A O      1 ? 
ATOM   2182 C CB     . LYS A 1 148 ? 21.341  -31.438 8.419   1    19.585 ? 1156 LYS A CB     1 ? 
ATOM   2183 C CG     . LYS A 1 148 ? 21.803  -32.446 9.454   1    24.891 ? 1156 LYS A CG     1 ? 
ATOM   2184 C CD     . LYS A 1 148 ? 22.69   -33.553 8.903   1    28.988 ? 1156 LYS A CD     1 ? 
ATOM   2185 C CE     . LYS A 1 148 ? 22.013  -34.57  8.027   1    32.794 ? 1156 LYS A CE     1 ? 
ATOM   2186 N NZ     . LYS A 1 148 ? 22.992  -35.618 7.666   1    36.421 ? 1156 LYS A NZ     1 ? 
ATOM   2187 H H      . LYS A 1 148 ? 18.716  -30.988 9.183   1    16.752 ? 1156 LYS A H      1 ? 
ATOM   2188 H HA     . LYS A 1 148 ? 21.385  -29.819 9.799   1    18.099 ? 1156 LYS A HA     1 c 
ATOM   2189 H HB2    . LYS A 1 148 ? 20.625  -31.921 7.752   1    20.365 ? 1156 LYS A HB2    1 c 
ATOM   2190 H HB3    . LYS A 1 148 ? 22.201  -31.125 7.824   1    20.365 ? 1156 LYS A HB3    1 c 
ATOM   2191 H HG2    . LYS A 1 148 ? 22.348  -31.913 10.236  1    24.403 ? 1156 LYS A HG2    1 c 
ATOM   2192 H HG3    . LYS A 1 148 ? 20.921  -32.896 9.914   1    24.403 ? 1156 LYS A HG3    1 c 
ATOM   2193 H HD2    . LYS A 1 148 ? 23.5    -33.09  8.336   1    28.798 ? 1156 LYS A HD2    1 c 
ATOM   2194 H HD3    . LYS A 1 148 ? 23.149  -34.074 9.747   1    28.74  ? 1156 LYS A HD3    1 c 
ATOM   2195 H HE2    . LYS A 1 148 ? 21.177  -35.026 8.56    1    32.682 ? 1156 LYS A HE2    1 c 
ATOM   2196 H HE3    . LYS A 1 148 ? 21.636  -34.094 7.119   1    32.683 ? 1156 LYS A HE3    1 c 
ATOM   2197 H HZ1    . LYS A 1 148 ? 22.532  -36.322 7.091   1    34.276 ? 1156 LYS A HZ1    1 ? 
ATOM   2198 H HZ2    . LYS A 1 148 ? 23.784  -35.206 7.138   1    32.639 ? 1156 LYS A HZ2    1 ? 
ATOM   2199 H HZ3    . LYS A 1 148 ? 23.366  -36.066 8.517   1    33.244 ? 1156 LYS A HZ3    1 ? 
ATOM   2200 N N      . ILE A 1 149 ? 19.279  -28.748 7.638   1    17.801 ? 1157 ILE A N      1 ? 
ATOM   2201 C CA     . ILE A 1 149 ? 19.07   -27.845 6.515   1    18.498 ? 1157 ILE A CA     1 ? 
ATOM   2202 C C      . ILE A 1 149 ? 19.747  -26.496 6.748   1    16.197 ? 1157 ILE A C      1 ? 
ATOM   2203 O O      . ILE A 1 149 ? 20.21   -25.855 5.8     1    14.26  ? 1157 ILE A O      1 ? 
ATOM   2204 C CB     . ILE A 1 149 ? 17.577  -27.665 6.242   1    20.635 ? 1157 ILE A CB     1 ? 
ATOM   2205 C CG1    . ILE A 1 149 ? 17.061  -28.938 5.569   1    19.43  ? 1157 ILE A CG1    1 ? 
ATOM   2206 C CG2    . ILE A 1 149 ? 17.31   -26.458 5.344   1    20.329 ? 1157 ILE A CG2    1 ? 
ATOM   2207 C CD1    . ILE A 1 149 ? 15.549  -28.903 5.393   1    24.214 ? 1157 ILE A CD1    1 ? 
ATOM   2208 H H      . ILE A 1 149 ? 18.488  -29.024 8.245   1    17.195 ? 1157 ILE A H      1 ? 
ATOM   2209 H HA     . ILE A 1 149 ? 19.52   -28.301 5.631   1    18.287 ? 1157 ILE A HA     1 c 
ATOM   2210 H HB     . ILE A 1 149 ? 17.055  -27.529 7.192   1    19.965 ? 1157 ILE A HB     1 c 
ATOM   2211 H HG12   . ILE A 1 149 ? 17.535  -29.045 4.591   1    20.666 ? 1157 ILE A HG12   1 c 
ATOM   2212 H HG13   . ILE A 1 149 ? 17.332  -29.802 6.178   1    20.703 ? 1157 ILE A HG13   1 c 
ATOM   2213 H HG21   . ILE A 1 149 ? 16.243  -26.394 5.126   1    20.385 ? 1157 ILE A HG21   1 c 
ATOM   2214 H HG22   . ILE A 1 149 ? 17.627  -25.544 5.849   1    20.325 ? 1157 ILE A HG22   1 c 
ATOM   2215 H HG23   . ILE A 1 149 ? 17.862  -26.568 4.409   1    20.328 ? 1157 ILE A HG23   1 c 
ATOM   2216 H HD11   . ILE A 1 149 ? 15.274  -28.124 4.68    1    22.834 ? 1157 ILE A HD11   1 c 
ATOM   2217 H HD12   . ILE A 1 149 ? 15.208  -29.871 5.019   1    22.773 ? 1157 ILE A HD12   1 c 
ATOM   2218 H HD13   . ILE A 1 149 ? 15.074  -28.7   6.355   1    22.726 ? 1157 ILE A HD13   1 c 
ATOM   2219 N N      . MET A 1 150 ? 19.757  -26.035 8.006   1    15.438 ? 1158 MET A N      1 ? 
ATOM   2220 C CA     . MET A 1 150 ? 20.206  -24.694 8.325   1    14.512 ? 1158 MET A CA     1 ? 
ATOM   2221 C C      . MET A 1 150 ? 21.577  -24.696 9.007   1    14.405 ? 1158 MET A C      1 ? 
ATOM   2222 O O      . MET A 1 150 ? 21.963  -23.7   9.638   1    13.544 ? 1158 MET A O      1 ? 
ATOM   2223 C CB     . MET A 1 150 ? 19.184  -23.98  9.212   1    14.585 ? 1158 MET A CB     1 ? 
ATOM   2224 C CG     . MET A 1 150 ? 17.802  -23.806 8.547   1    14.603 ? 1158 MET A CG     1 ? 
ATOM   2225 S SD     . MET A 1 150 ? 17.783  -22.797 7.044   1    13.232 ? 1158 MET A SD     1 ? 
ATOM   2226 C CE     . MET A 1 150 ? 17.787  -21.163 7.804   1    11.612 ? 1158 MET A CE     1 ? 
ATOM   2227 H H      . MET A 1 150 ? 19.481  -26.634 8.804   1    15.243 ? 1158 MET A H      1 ? 
ATOM   2228 H HA     . MET A 1 150 ? 20.303  -24.142 7.389   1    14.676 ? 1158 MET A HA     1 c 
ATOM   2229 H HB2    . MET A 1 150 ? 19.065  -24.549 10.135  1    14.607 ? 1158 MET A HB2    1 c 
ATOM   2230 H HB3    . MET A 1 150 ? 19.576  -22.996 9.475   1    14.573 ? 1158 MET A HB3    1 c 
ATOM   2231 H HG2    . MET A 1 150 ? 17.406  -24.793 8.299   1    14.336 ? 1158 MET A HG2    1 c 
ATOM   2232 H HG3    . MET A 1 150 ? 17.12   -23.354 9.27    1    14.336 ? 1158 MET A HG3    1 c 
ATOM   2233 H HE1    . MET A 1 150 ? 18.725  -21.015 8.343   1    11.995 ? 1158 MET A HE1    1 c 
ATOM   2234 H HE2    . MET A 1 150 ? 17.687  -20.402 7.027   1    12.004 ? 1158 MET A HE2    1 c 
ATOM   2235 H HE3    . MET A 1 150 ? 16.948  -21.083 8.498   1    12.044 ? 1158 MET A HE3    1 c 
ATOM   2236 N N      . LEU A 1 151 ? 22.352  -25.763 8.861   1    13.212 ? 1159 LEU A N      1 ? 
ATOM   2237 C CA     . LEU A 1 151 ? 23.734  -25.706 9.324   1    13.702 ? 1159 LEU A CA     1 ? 
ATOM   2238 C C      . LEU A 1 151 ? 24.47   -24.614 8.543   1    14.452 ? 1159 LEU A C      1 ? 
ATOM   2239 O O      . LEU A 1 151 ? 24.199  -24.361 7.367   1    14.669 ? 1159 LEU A O      1 ? 
ATOM   2240 C CB     . LEU A 1 151 ? 24.424  -27.049 9.143   1    13.987 ? 1159 LEU A CB     1 ? 
ATOM   2241 C CG     . LEU A 1 151 ? 23.839  -28.203 9.966   1    15.22  ? 1159 LEU A CG     1 ? 
ATOM   2242 C CD1    . LEU A 1 151 ? 24.554  -29.514 9.643   1    15.106 ? 1159 LEU A CD1    1 ? 
ATOM   2243 C CD2    . LEU A 1 151 ? 23.895  -27.931 11.469  1    13.393 ? 1159 LEU A CD2    1 ? 
ATOM   2244 H H      . LEU A 1 151 ? 21.958  -26.592 8.41    1    13.982 ? 1159 LEU A H      1 ? 
ATOM   2245 H HA     . LEU A 1 151 ? 23.733  -25.439 10.382  1    13.784 ? 1159 LEU A HA     1 c 
ATOM   2246 H HB2    . LEU A 1 151 ? 24.375  -27.318 8.086   1    14.182 ? 1159 LEU A HB2    1 c 
ATOM   2247 H HB3    . LEU A 1 151 ? 25.476  -26.931 9.411   1    14.182 ? 1159 LEU A HB3    1 c 
ATOM   2248 H HG     . LEU A 1 151 ? 22.79   -28.316 9.688   1    14.662 ? 1159 LEU A HG     1 c 
ATOM   2249 H HD11   . LEU A 1 151 ? 24.471  -29.721 8.574   1    15.142 ? 1159 LEU A HD11   1 c 
ATOM   2250 H HD12   . LEU A 1 151 ? 25.608  -29.432 9.916   1    15.142 ? 1159 LEU A HD12   1 c 
ATOM   2251 H HD13   . LEU A 1 151 ? 24.094  -30.328 10.206  1    15.157 ? 1159 LEU A HD13   1 c 
ATOM   2252 H HD21   . LEU A 1 151 ? 24.929  -27.752 11.77   1    13.876 ? 1159 LEU A HD21   1 c 
ATOM   2253 H HD22   . LEU A 1 151 ? 23.291  -27.052 11.704  1    13.875 ? 1159 LEU A HD22   1 c 
ATOM   2254 H HD23   . LEU A 1 151 ? 23.503  -28.795 12.011  1    13.878 ? 1159 LEU A HD23   1 c 
ATOM   2255 N N      . LEU A 1 152 ? 25.412  -23.954 9.216   1    13.972 ? 1160 LEU A N      1 ? 
ATOM   2256 C CA     . LEU A 1 152 ? 26.15   -22.867 8.576   1    14.282 ? 1160 LEU A CA     1 ? 
ATOM   2257 C C      . LEU A 1 152 ? 27.297  -23.445 7.751   1    12.809 ? 1160 LEU A C      1 ? 
ATOM   2258 O O      . LEU A 1 152 ? 28.151  -24.141 8.305   1    13.192 ? 1160 LEU A O      1 ? 
ATOM   2259 C CB     . LEU A 1 152 ? 26.718  -21.935 9.632   1    14.974 ? 1160 LEU A CB     1 ? 
ATOM   2260 C CG     . LEU A 1 152 ? 27.477  -20.71  9.1     1    16.172 ? 1160 LEU A CG     1 ? 
ATOM   2261 C CD1    . LEU A 1 152 ? 26.571  -19.767 8.318   1    14.886 ? 1160 LEU A CD1    1 ? 
ATOM   2262 C CD2    . LEU A 1 152 ? 28.152  -19.986 10.258  1    17.579 ? 1160 LEU A CD2    1 ? 
ATOM   2263 H H      . LEU A 1 152 ? 25.537  -24.14  10.222  1    13.241 ? 1160 LEU A H      1 ? 
ATOM   2264 H HA     . LEU A 1 152 ? 25.471  -22.311 7.928   1    14.083 ? 1160 LEU A HA     1 c 
ATOM   2265 H HB2    . LEU A 1 152 ? 25.894  -21.585 10.258  1    15.08  ? 1160 LEU A HB2    1 c 
ATOM   2266 H HB3    . LEU A 1 152 ? 27.395  -22.511 10.266  1    15.126 ? 1160 LEU A HB3    1 c 
ATOM   2267 H HG     . LEU A 1 152 ? 28.26   -21.061 8.425   1    15.935 ? 1160 LEU A HG     1 c 
ATOM   2268 H HD11   . LEU A 1 152 ? 27.151  -18.913 7.964   1    15.228 ? 1160 LEU A HD11   1 c 
ATOM   2269 H HD12   . LEU A 1 152 ? 26.145  -20.296 7.462   1    15.221 ? 1160 LEU A HD12   1 c 
ATOM   2270 H HD13   . LEU A 1 152 ? 25.764  -19.416 8.965   1    15.223 ? 1160 LEU A HD13   1 c 
ATOM   2271 H HD21   . LEU A 1 152 ? 28.692  -19.115 9.88    1    17.16  ? 1160 LEU A HD21   1 c 
ATOM   2272 H HD22   . LEU A 1 152 ? 27.396  -19.66  10.976  1    17.16  ? 1160 LEU A HD22   1 c 
ATOM   2273 H HD23   . LEU A 1 152 ? 28.854  -20.661 10.752  1    17.11  ? 1160 LEU A HD23   1 c 
ATOM   2274 N N      . PRO A 1 153 ? 27.366  -23.175 6.439   1    13.692 ? 1161 PRO A N      1 ? 
ATOM   2275 C CA     . PRO A 1 153 ? 28.527  -23.617 5.67    1    14.935 ? 1161 PRO A CA     1 ? 
ATOM   2276 C C      . PRO A 1 153 ? 29.762  -22.812 6.048   1    13.21  ? 1161 PRO A C      1 ? 
ATOM   2277 O O      . PRO A 1 153 ? 29.818  -21.616 5.783   1    13.231 ? 1161 PRO A O      1 ? 
ATOM   2278 C CB     . PRO A 1 153 ? 28.118  -23.393 4.21    1    14.584 ? 1161 PRO A CB     1 ? 
ATOM   2279 C CG     . PRO A 1 153 ? 26.607  -23.211 4.254   1    14.483 ? 1161 PRO A CG     1 ? 
ATOM   2280 C CD     . PRO A 1 153 ? 26.339  -22.576 5.574   1    14.042 ? 1161 PRO A CD     1 ? 
ATOM   2281 H HA     . PRO A 1 153 ? 28.706  -24.679 5.851   1    14.308 ? 1161 PRO A HA     1 c 
ATOM   2282 H HB2    . PRO A 1 153 ? 28.604  -22.505 3.801   1    14.627 ? 1161 PRO A HB2    1 c 
ATOM   2283 H HB3    . PRO A 1 153 ? 28.388  -24.254 3.595   1    14.635 ? 1161 PRO A HB3    1 c 
ATOM   2284 H HG2    . PRO A 1 153 ? 26.268  -22.566 3.441   1    14.406 ? 1161 PRO A HG2    1 c 
ATOM   2285 H HG3    . PRO A 1 153 ? 26.096  -24.173 4.179   1    14.406 ? 1161 PRO A HG3    1 c 
ATOM   2286 H HD2    . PRO A 1 153 ? 26.462  -21.494 5.527   1    14.07  ? 1161 PRO A HD2    1 c 
ATOM   2287 H HD3    . PRO A 1 153 ? 25.337  -22.812 5.933   1    14.065 ? 1161 PRO A HD3    1 c 
ATOM   2288 N N      . GLU A 1 154 ? 30.73   -23.469 6.689   1    13.502 ? 1162 GLU A N      1 ? 
ATOM   2289 C CA     . GLU A 1 154 ? 31.921  -22.822 7.213   1    15.156 ? 1162 GLU A CA     1 ? 
ATOM   2290 C C      . GLU A 1 154 ? 33.175  -23.105 6.378   1    16.444 ? 1162 GLU A C      1 ? 
ATOM   2291 O O      . GLU A 1 154 ? 34.237  -22.565 6.703   1    19.295 ? 1162 GLU A O      1 ? 
ATOM   2292 C CB     . GLU A 1 154 ? 32.16   -23.207 8.677   1    15.21  ? 1162 GLU A CB     1 ? 
ATOM   2293 C CG     . GLU A 1 154 ? 31.033  -22.733 9.564   1    15.681 ? 1162 GLU A CG     1 ? 
ATOM   2294 C CD     . GLU A 1 154 ? 31.24   -23.006 11.038  1    17.563 ? 1162 GLU A CD     1 ? 
ATOM   2295 O OE1    . GLU A 1 154 ? 32.307  -23.499 11.457  1    18.057 ? 1162 GLU A OE1    1 ? 
ATOM   2296 O OE2    . GLU A 1 154 ? 30.289  -22.702 11.789  1    17.691 ? 1162 GLU A OE2    1 ? 
ATOM   2297 H H      . GLU A 1 154 ? 30.575  -24.471 6.894   1    13.821 ? 1162 GLU A H      1 ? 
ATOM   2298 H HA     . GLU A 1 154 ? 31.749  -21.745 7.194   1    15.048 ? 1162 GLU A HA     1 c 
ATOM   2299 H HB2    . GLU A 1 154 ? 32.252  -24.293 8.749   1    15.304 ? 1162 GLU A HB2    1 c 
ATOM   2300 H HB3    . GLU A 1 154 ? 33.101  -22.767 9.013   1    15.321 ? 1162 GLU A HB3    1 c 
ATOM   2301 H HG2    . GLU A 1 154 ? 30.903  -21.658 9.427   1    15.966 ? 1162 GLU A HG2    1 c 
ATOM   2302 H HG3    . GLU A 1 154 ? 30.108  -23.218 9.25    1    15.95  ? 1162 GLU A HG3    1 c 
ATOM   2303 N N      . GLU A 1 155 ? 33.068  -23.876 5.301   1    17.701 ? 1163 GLU A N      1 ? 
ATOM   2304 C CA     . GLU A 1 155 ? 34.232  -24.213 4.497   1    19.453 ? 1163 GLU A CA     1 ? 
ATOM   2305 C C      . GLU A 1 155 ? 34.967  -22.955 4.015   1    18.209 ? 1163 GLU A C      1 ? 
ATOM   2306 O O      . GLU A 1 155 ? 36.197  -22.917 3.948   1    18.042 ? 1163 GLU A O      1 ? 
ATOM   2307 C CB     . GLU A 1 155 ? 33.834  -25.063 3.286   1    22.412 ? 1163 GLU A CB     1 ? 
ATOM   2308 C CG     . GLU A 1 155 ? 33.303  -26.463 3.602   1    30.142 ? 1163 GLU A CG     1 ? 
ATOM   2309 C CD     . GLU A 1 155 ? 31.972  -26.503 4.365   1    31.423 ? 1163 GLU A CD     1 ? 
ATOM   2310 O OE1    . GLU A 1 155 ? 31.832  -27.386 5.247   1    31.067 ? 1163 GLU A OE1    1 ? 
ATOM   2311 O OE2    . GLU A 1 155 ? 31.098  -25.629 4.111   1    29.613 ? 1163 GLU A OE2    1 ? 
ATOM   2312 H H      . GLU A 1 155 ? 32.15   -24.214 4.973   1    17.53  ? 1163 GLU A H      1 ? 
ATOM   2313 H HA     . GLU A 1 155 ? 34.916  -24.796 5.118   1    19.366 ? 1163 GLU A HA     1 c 
ATOM   2314 H HB2    . GLU A 1 155 ? 33.069  -24.525 2.724   1    23.437 ? 1163 GLU A HB2    1 c 
ATOM   2315 H HB3    . GLU A 1 155 ? 34.705  -25.169 2.637   1    23.243 ? 1163 GLU A HB3    1 c 
ATOM   2316 H HG2    . GLU A 1 155 ? 33.177  -27.011 2.666   1    28.506 ? 1163 GLU A HG2    1 c 
ATOM   2317 H HG3    . GLU A 1 155 ? 34.051  -26.998 4.192   1    28.505 ? 1163 GLU A HG3    1 c 
ATOM   2318 N N      . ASP A 1 156 ? 34.208  -21.937 3.639   1    15.738 ? 1164 ASP A N      1 ? 
ATOM   2319 C CA     . ASP A 1 156 ? 34.757  -20.664 3.196   1    14.614 ? 1164 ASP A CA     1 ? 
ATOM   2320 C C      . ASP A 1 156 ? 34.488  -19.632 4.286   1    14.255 ? 1164 ASP A C      1 ? 
ATOM   2321 O O      . ASP A 1 156 ? 33.365  -19.143 4.415   1    11.792 ? 1164 ASP A O      1 ? 
ATOM   2322 C CB     . ASP A 1 156 ? 34.106  -20.239 1.886   1    14.467 ? 1164 ASP A CB     1 ? 
ATOM   2323 C CG     . ASP A 1 156 ? 34.595  -18.9   1.387   1    16.141 ? 1164 ASP A CG     1 ? 
ATOM   2324 O OD1    . ASP A 1 156 ? 35.528  -18.349 2.002   1    16.271 ? 1164 ASP A OD1    1 ? 
ATOM   2325 O OD2    . ASP A 1 156 ? 34.038  -18.416 0.377   1    16.414 ? 1164 ASP A OD2    1 ? 
ATOM   2326 H H      . ASP A 1 156 ? 33.179  -22.073 3.679   1    15.744 ? 1164 ASP A H      1 ? 
ATOM   2327 H HA     . ASP A 1 156 ? 35.832  -20.771 3.047   1    14.796 ? 1164 ASP A HA     1 c 
ATOM   2328 H HB2    . ASP A 1 156 ? 34.317  -20.99  1.122   1    14.857 ? 1164 ASP A HB2    1 c 
ATOM   2329 H HB3    . ASP A 1 156 ? 33.025  -20.186 2.023   1    14.866 ? 1164 ASP A HB3    1 c 
ATOM   2330 N N      . PRO A 1 157 ? 35.483  -19.274 5.112   1    17.655 ? 1165 PRO A N      1 ? 
ATOM   2331 C CA     . PRO A 1 157 ? 35.25   -18.285 6.162   1    16.387 ? 1165 PRO A CA     1 ? 
ATOM   2332 C C      . PRO A 1 157 ? 35.041  -16.876 5.625   1    15.092 ? 1165 PRO A C      1 ? 
ATOM   2333 O O      . PRO A 1 157 ? 34.728  -15.974 6.412   1    16.092 ? 1165 PRO A O      1 ? 
ATOM   2334 C CB     . PRO A 1 157 ? 36.491  -18.377 7.042   1    19.063 ? 1165 PRO A CB     1 ? 
ATOM   2335 C CG     . PRO A 1 157 ? 37.558  -18.804 6.058   1    18.8   ? 1165 PRO A CG     1 ? 
ATOM   2336 C CD     . PRO A 1 157 ? 36.886  -19.728 5.087   1    16.819 ? 1165 PRO A CD     1 ? 
ATOM   2337 H HA     . PRO A 1 157 ? 34.375  -18.58  6.744   1    16.787 ? 1165 PRO A HA     1 c 
ATOM   2338 H HB2    . PRO A 1 157 ? 36.731  -17.41  7.486   1    18.374 ? 1165 PRO A HB2    1 c 
ATOM   2339 H HB3    . PRO A 1 157 ? 36.361  -19.121 7.831   1    18.393 ? 1165 PRO A HB3    1 c 
ATOM   2340 H HG2    . PRO A 1 157 ? 37.969  -17.938 5.535   1    18.402 ? 1165 PRO A HG2    1 c 
ATOM   2341 H HG3    . PRO A 1 157 ? 38.372  -19.32  6.572   1    18.402 ? 1165 PRO A HG3    1 c 
ATOM   2342 H HD2    . PRO A 1 157 ? 37.308  -19.628 4.085   1    17.391 ? 1165 PRO A HD2    1 c 
ATOM   2343 H HD3    . PRO A 1 157 ? 36.962  -20.769 5.41    1    17.41  ? 1165 PRO A HD3    1 c 
ATOM   2344 N N      . ASN A 1 158 ? 35.192  -16.675 4.309   1    16.625 ? 1166 ASN A N      1 ? 
ATOM   2345 C CA     . ASN A 1 158 ? 34.9    -15.402 3.674   1    17.144 ? 1166 ASN A CA     1 ? 
ATOM   2346 C C      . ASN A 1 158 ? 33.681  -15.473 2.748   1    16.656 ? 1166 ASN A C      1 ? 
ATOM   2347 O O      . ASN A 1 158 ? 33.518  -14.633 1.859   1    16.527 ? 1166 ASN A O      1 ? 
ATOM   2348 C CB     . ASN A 1 158 ? 36.141  -14.886 2.948   1    17.871 ? 1166 ASN A CB     1 ? 
ATOM   2349 C CG     . ASN A 1 158 ? 37.306  -14.762 3.898   1    18.683 ? 1166 ASN A CG     1 ? 
ATOM   2350 O OD1    . ASN A 1 158 ? 37.177  -14.193 4.981   1    17.015 ? 1166 ASN A OD1    1 ? 
ATOM   2351 N ND2    . ASN A 1 158 ? 38.431  -15.352 3.534   1    20.975 ? 1166 ASN A ND2    1 ? 
ATOM   2352 H H      . ASN A 1 158 ? 35.492  -17.453 3.676   1    15.621 ? 1166 ASN A H      1 ? 
ATOM   2353 H HA     . ASN A 1 158 ? 34.672  -14.683 4.462   1    17.064 ? 1166 ASN A HA     1 c 
ATOM   2354 H HB2    . ASN A 1 158 ? 36.402  -15.573 2.141   1    17.901 ? 1166 ASN A HB2    1 c 
ATOM   2355 H HB3    . ASN A 1 158 ? 35.926  -13.909 2.51    1    17.881 ? 1166 ASN A HB3    1 c 
ATOM   2356 H HD21   . ASN A 1 158 ? 39.255  -15.266 4.111   1    20.015 ? 1166 ASN A HD21   1 ? 
ATOM   2357 H HD22   . ASN A 1 158 ? 38.45   -15.87  2.662   1    20.112 ? 1166 ASN A HD22   1 ? 
ATOM   2358 N N      . ALA A 1 159 ? 32.816  -16.461 2.971   1    15.983 ? 1167 ALA A N      1 ? 
ATOM   2359 C CA     . ALA A 1 159 ? 31.582  -16.588 2.215   1    15.981 ? 1167 ALA A CA     1 ? 
ATOM   2360 C C      . ALA A 1 159 ? 30.653  -15.4   2.48    1    14.516 ? 1167 ALA A C      1 ? 
ATOM   2361 O O      . ALA A 1 159 ? 30.821  -14.637 3.436   1    16.03  ? 1167 ALA A O      1 ? 
ATOM   2362 C CB     . ALA A 1 159 ? 30.881  -17.883 2.596   1    16.468 ? 1167 ALA A CB     1 ? 
ATOM   2363 H H      . ALA A 1 159 ? 32.977  -17.094 3.777   1    15.005 ? 1167 ALA A H      1 ? 
ATOM   2364 H HA     . ALA A 1 159 ? 31.827  -16.606 1.151   1    15.795 ? 1167 ALA A HA     1 c 
ATOM   2365 H HB1    . ALA A 1 159 ? 31.529  -18.732 2.367   1    16.317 ? 1167 ALA A HB1    1 c 
ATOM   2366 H HB2    . ALA A 1 159 ? 30.657  -17.879 3.664   1    16.327 ? 1167 ALA A HB2    1 c 
ATOM   2367 H HB3    . ALA A 1 159 ? 29.951  -17.977 2.032   1    16.322 ? 1167 ALA A HB3    1 c 
ATOM   2368 N N      . THR A 1 160 ? 29.652  -15.268 1.618   1    13.656 ? 1168 THR A N      1 ? 
ATOM   2369 C CA     . THR A 1 160 ? 28.571  -14.32  1.802   1    14.258 ? 1168 THR A CA     1 ? 
ATOM   2370 C C      . THR A 1 160 ? 27.311  -15.081 2.19    1    13.984 ? 1168 THR A C      1 ? 
ATOM   2371 O O      . THR A 1 160 ? 26.989  -16.11  1.579   1    14.481 ? 1168 THR A O      1 ? 
ATOM   2372 C CB     . THR A 1 160 ? 28.36   -13.481 0.542   1    15.905 ? 1168 THR A CB     1 ? 
ATOM   2373 O OG1    . THR A 1 160 ? 29.526  -12.674 0.344   1    16.09  ? 1168 THR A OG1    1 ? 
ATOM   2374 C CG2    . THR A 1 160 ? 27.159  -12.563 0.698   1    15.31  ? 1168 THR A CG2    1 ? 
ATOM   2375 H H      . THR A 1 160 ? 29.654  -15.914 0.824   1    14.353 ? 1168 THR A H      1 ? 
ATOM   2376 H HA     . THR A 1 160 ? 28.84   -13.651 2.617   1    14.371 ? 1168 THR A HA     1 c 
ATOM   2377 H HB     . THR A 1 160 ? 28.215  -14.133 -0.322  1    15.533 ? 1168 THR A HB     1 c 
ATOM   2378 H HG1    . THR A 1 160 ? 30.197  -13.15  -0.161  1    16.522 ? 1168 THR A HG1    1 ? 
ATOM   2379 H HG21   . THR A 1 160 ? 26.247  -13.159 0.767   1    15.458 ? 1168 THR A HG21   1 c 
ATOM   2380 H HG22   . THR A 1 160 ? 27.271  -11.965 1.606   1    15.465 ? 1168 THR A HG22   1 c 
ATOM   2381 H HG23   . THR A 1 160 ? 27.092  -11.9   -0.167  1    15.446 ? 1168 THR A HG23   1 c 
ATOM   2382 N N      . HIS A 1 161 ? 26.633  -14.579 3.237   1    14.686 ? 1169 HIS A N      1 ? 
ATOM   2383 C CA     . HIS A 1 161 ? 25.445  -15.214 3.793   1    14.51  ? 1169 HIS A CA     1 ? 
ATOM   2384 C C      . HIS A 1 161 ? 24.337  -14.168 3.877   1    14.225 ? 1169 HIS A C      1 ? 
ATOM   2385 O O      . HIS A 1 161 ? 24.419  -13.234 4.693   1    16.09  ? 1169 HIS A O      1 ? 
ATOM   2386 C CB     . HIS A 1 161 ? 25.751  -15.759 5.19    1    14.182 ? 1169 HIS A CB     1 ? 
ATOM   2387 C CG     . HIS A 1 161 ? 26.857  -16.75  5.235   1    14.483 ? 1169 HIS A CG     1 ? 
ATOM   2388 N ND1    . HIS A 1 161 ? 26.694  -18.064 4.848   1    12.821 ? 1169 HIS A ND1    1 ? 
ATOM   2389 C CD2    . HIS A 1 161 ? 28.139  -16.62  5.656   1    14.583 ? 1169 HIS A CD2    1 ? 
ATOM   2390 C CE1    . HIS A 1 161 ? 27.846  -18.705 5.023   1    15.731 ? 1169 HIS A CE1    1 ? 
ATOM   2391 N NE2    . HIS A 1 161 ? 28.74   -17.851 5.506   1    14.39  ? 1169 HIS A NE2    1 ? 
ATOM   2392 H H      . HIS A 1 161 ? 27.042  -13.761 3.735   1    14.564 ? 1169 HIS A H      1 ? 
ATOM   2393 H HA     . HIS A 1 161 ? 25.118  -16.021 3.136   1    14.421 ? 1169 HIS A HA     1 c 
ATOM   2394 H HB2    . HIS A 1 161 ? 26.003  -14.921 5.844   1    14.329 ? 1169 HIS A HB2    1 c 
ATOM   2395 H HB3    . HIS A 1 161 ? 24.846  -16.223 5.588   1    14.321 ? 1169 HIS A HB3    1 c 
ATOM   2396 H HD2    . HIS A 1 161 ? 28.614  -15.719 6.03    1    14.524 ? 1169 HIS A HD2    1 c 
ATOM   2397 H HE1    . HIS A 1 161 ? 28.025  -19.75  4.793   1    14.759 ? 1169 HIS A HE1    1 c 
ATOM   2398 H HE2    . HIS A 1 161 ? 29.717  -18.034 5.735   1    15.755 ? 1169 HIS A HE2    1 ? 
ATOM   2399 N N      . ILE A 1 162 ? 23.301  -14.347 3.062   1    13.223 ? 1170 ILE A N      1 ? 
ATOM   2400 C CA     . ILE A 1 162 ? 22.158  -13.444 3.006   1    12.481 ? 1170 ILE A CA     1 ? 
ATOM   2401 C C      . ILE A 1 162 ? 21.03   -14.129 3.766   1    12.894 ? 1170 ILE A C      1 ? 
ATOM   2402 O O      . ILE A 1 162 ? 20.561  -15.197 3.359   1    12.645 ? 1170 ILE A O      1 ? 
ATOM   2403 C CB     . ILE A 1 162 ? 21.752  -13.146 1.555   1    12.969 ? 1170 ILE A CB     1 ? 
ATOM   2404 C CG1    . ILE A 1 162 ? 22.919  -12.561 0.755   1    13.05  ? 1170 ILE A CG1    1 ? 
ATOM   2405 C CG2    . ILE A 1 162 ? 20.533  -12.25  1.542   1    13.337 ? 1170 ILE A CG2    1 ? 
ATOM   2406 C CD1    . ILE A 1 162 ? 22.703  -12.564 -0.739  1    12.71  ? 1170 ILE A CD1    1 ? 
ATOM   2407 H H      . ILE A 1 162 ? 23.311  -15.155 2.409   1    12.915 ? 1170 ILE A H      1 ? 
ATOM   2408 H HA     . ILE A 1 162 ? 22.414  -12.508 3.506   1    12.815 ? 1170 ILE A HA     1 c 
ATOM   2409 H HB     . ILE A 1 162 ? 21.474  -14.093 1.088   1    12.961 ? 1170 ILE A HB     1 c 
ATOM   2410 H HG12   . ILE A 1 162 ? 23.087  -11.533 1.082   1    12.957 ? 1170 ILE A HG12   1 c 
ATOM   2411 H HG13   . ILE A 1 162 ? 23.821  -13.134 0.978   1    12.958 ? 1170 ILE A HG13   1 c 
ATOM   2412 H HG21   . ILE A 1 162 ? 20.735  -11.349 2.126   1    13.226 ? 1170 ILE A HG21   1 c 
ATOM   2413 H HG22   . ILE A 1 162 ? 20.297  -11.967 0.514   1    13.221 ? 1170 ILE A HG22   1 c 
ATOM   2414 H HG23   . ILE A 1 162 ? 19.682  -12.778 1.976   1    13.209 ? 1170 ILE A HG23   1 c 
ATOM   2415 H HD11   . ILE A 1 162 ? 22.545  -13.588 -1.084  1    12.806 ? 1170 ILE A HD11   1 c 
ATOM   2416 H HD12   . ILE A 1 162 ? 21.826  -11.96  -0.985  1    12.809 ? 1170 ILE A HD12   1 c 
ATOM   2417 H HD13   . ILE A 1 162 ? 23.58   -12.146 -1.236  1    12.808 ? 1170 ILE A HD13   1 c 
ATOM   2418 N N      . MET A 1 163 ? 20.624  -13.528 4.884   1    13.371 ? 1171 MET A N      1 ? 
ATOM   2419 C CA     . MET A 1 163 ? 19.728  -14.162 5.848   1    14.344 ? 1171 MET A CA     1 ? 
ATOM   2420 C C      . MET A 1 163 ? 18.37   -13.454 5.83    1    14.353 ? 1171 MET A C      1 ? 
ATOM   2421 O O      . MET A 1 163 ? 18.283  -12.278 6.195   1    14.97  ? 1171 MET A O      1 ? 
ATOM   2422 C CB     . MET A 1 163 ? 20.321  -14.189 7.258   1    13.038 ? 1171 MET A CB     1 ? 
ATOM   2423 C CG     . MET A 1 163 ? 21.713  -14.768 7.347   1    13.03  ? 1171 MET A CG     1 ? 
ATOM   2424 S SD     . MET A 1 163 ? 22.542  -14.318 8.894   1    13.929 ? 1171 MET A SD     1 ? 
ATOM   2425 C CE     . MET A 1 163 ? 24.25   -14.694 8.468   1    15.783 ? 1171 MET A CE     1 ? 
ATOM   2426 H H      . MET A 1 163 ? 20.951  -12.568 5.092   1    13.403 ? 1171 MET A H      1 ? 
ATOM   2427 H HA     . MET A 1 163 ? 19.566  -15.191 5.522   1    13.904 ? 1171 MET A HA     1 c 
ATOM   2428 H HB2    . MET A 1 163 ? 20.339  -13.168 7.645   1    13.308 ? 1171 MET A HB2    1 c 
ATOM   2429 H HB3    . MET A 1 163 ? 19.656  -14.772 7.898   1    13.299 ? 1171 MET A HB3    1 c 
ATOM   2430 H HG2    . MET A 1 163 ? 21.658  -15.857 7.279   1    13.191 ? 1171 MET A HG2    1 c 
ATOM   2431 H HG3    . MET A 1 163 ? 22.312  -14.407 6.509   1    13.192 ? 1171 MET A HG3    1 c 
ATOM   2432 H HE1    . MET A 1 163 ? 24.329  -15.74  8.164   1    15.294 ? 1171 MET A HE1    1 c 
ATOM   2433 H HE2    . MET A 1 163 ? 24.569  -14.052 7.645   1    15.308 ? 1171 MET A HE2    1 c 
ATOM   2434 H HE3    . MET A 1 163 ? 24.889  -14.516 9.336   1    15.279 ? 1171 MET A HE3    1 c 
ATOM   2435 N N      . ILE A 1 164 ? 17.331  -14.175 5.401   1    14.798 ? 1172 ILE A N      1 ? 
ATOM   2436 C CA     . ILE A 1 164 ? 15.993  -13.619 5.238   1    14.731 ? 1172 ILE A CA     1 ? 
ATOM   2437 C C      . ILE A 1 164 ? 15.081  -14.207 6.317   1    13.739 ? 1172 ILE A C      1 ? 
ATOM   2438 O O      . ILE A 1 164 ? 14.73   -15.389 6.257   1    14.971 ? 1172 ILE A O      1 ? 
ATOM   2439 C CB     . ILE A 1 164 ? 15.409  -13.905 3.841   1    13.26  ? 1172 ILE A CB     1 ? 
ATOM   2440 C CG1    . ILE A 1 164 ? 16.388  -13.571 2.73    1    13.152 ? 1172 ILE A CG1    1 ? 
ATOM   2441 C CG2    . ILE A 1 164 ? 14.097  -13.156 3.691   1    13.622 ? 1172 ILE A CG2    1 ? 
ATOM   2442 C CD1    . ILE A 1 164 ? 16.882  -12.138 2.71    1    12.879 ? 1172 ILE A CD1    1 ? 
ATOM   2443 H H      . ILE A 1 164 ? 17.507  -15.156 5.12    1    13.841 ? 1172 ILE A H      1 ? 
ATOM   2444 H HA     . ILE A 1 164 ? 16.046  -12.537 5.376   1    14.297 ? 1172 ILE A HA     1 c 
ATOM   2445 H HB     . ILE A 1 164 ? 15.193  -14.973 3.783   1    13.555 ? 1172 ILE A HB     1 c 
ATOM   2446 H HG12   . ILE A 1 164 ? 17.252  -14.233 2.819   1    13.124 ? 1172 ILE A HG12   1 c 
ATOM   2447 H HG13   . ILE A 1 164 ? 15.909  -13.783 1.772   1    13.117 ? 1172 ILE A HG13   1 c 
ATOM   2448 H HG21   . ILE A 1 164 ? 14.26   -12.092 3.879   1    13.528 ? 1172 ILE A HG21   1 c 
ATOM   2449 H HG22   . ILE A 1 164 ? 13.715  -13.288 2.677   1    13.528 ? 1172 ILE A HG22   1 c 
ATOM   2450 H HG23   . ILE A 1 164 ? 13.368  -13.542 4.406   1    13.553 ? 1172 ILE A HG23   1 c 
ATOM   2451 H HD11   . ILE A 1 164 ? 17.542  -11.99  1.853   1    12.973 ? 1172 ILE A HD11   1 c 
ATOM   2452 H HD12   . ILE A 1 164 ? 16.031  -11.458 2.634   1    13.014 ? 1172 ILE A HD12   1 c 
ATOM   2453 H HD13   . ILE A 1 164 ? 17.431  -11.927 3.63    1    12.99  ? 1172 ILE A HD13   1 c 
ATOM   2454 N N      . ALA A 1 165 ? 14.676  -13.383 7.267   1    15.131 ? 1173 ALA A N      1 ? 
ATOM   2455 C CA     . ALA A 1 165 ? 13.866  -13.815 8.395   1    15.276 ? 1173 ALA A CA     1 ? 
ATOM   2456 C C      . ALA A 1 165 ? 12.549  -13.054 8.446   1    16.606 ? 1173 ALA A C      1 ? 
ATOM   2457 O O      . ALA A 1 165 ? 12.485  -11.862 8.15    1    14.242 ? 1173 ALA A O      1 ? 
ATOM   2458 C CB     . ALA A 1 165 ? 14.574  -13.543 9.722   1    14.292 ? 1173 ALA A CB     1 ? 
ATOM   2459 H H      . ALA A 1 165 ? 14.936  -12.384 7.231   1    13.92  ? 1173 ALA A H      1 ? 
ATOM   2460 H HA     . ALA A 1 165 ? 13.656  -14.88  8.298   1    15.26  ? 1173 ALA A HA     1 c 
ATOM   2461 H HB1    . ALA A 1 165 ? 13.939  -13.864 10.55   1    14.545 ? 1173 ALA A HB1    1 c 
ATOM   2462 H HB2    . ALA A 1 165 ? 15.514  -14.094 9.756   1    14.494 ? 1173 ALA A HB2    1 c 
ATOM   2463 H HB3    . ALA A 1 165 ? 14.778  -12.475 9.818   1    14.558 ? 1173 ALA A HB3    1 c 
ATOM   2464 N N      . THR A 1 166 ? 11.499  -13.751 8.885   1    16.773 ? 1174 THR A N      1 ? 
ATOM   2465 C CA     . THR A 1 166 ? 10.311  -13.097 9.406   1    17.674 ? 1174 THR A CA     1 ? 
ATOM   2466 C C      . THR A 1 166 ? 10.065  -13.594 10.825  1    16.343 ? 1174 THR A C      1 ? 
ATOM   2467 O O      . THR A 1 166 ? 10.172  -14.789 11.097  1    18.144 ? 1174 THR A O      1 ? 
ATOM   2468 C CB     . THR A 1 166 ? 9.065   -13.309 8.521   1    16.788 ? 1174 THR A CB     1 ? 
ATOM   2469 O OG1    . THR A 1 166 ? 8.753   -14.691 8.411   1    16.026 ? 1174 THR A OG1    1 ? 
ATOM   2470 C CG2    . THR A 1 166 ? 9.281   -12.702 7.139   1    16.655 ? 1174 THR A CG2    1 ? 
ATOM   2471 H H      . THR A 1 166 ? 11.542  -14.789 8.898   1    17.235 ? 1174 THR A H      1 ? 
ATOM   2472 H HA     . THR A 1 166 ? 10.511  -12.027 9.452   1    17.083 ? 1174 THR A HA     1 c 
ATOM   2473 H HB     . THR A 1 166 ? 8.22    -12.796 8.984   1    16.765 ? 1174 THR A HB     1 c 
ATOM   2474 H HG1    . THR A 1 166 ? 9.302   -15.106 7.709   1    16.186 ? 1174 THR A HG1    1 ? 
ATOM   2475 H HG21   . THR A 1 166 ? 9.467   -11.631 7.236   1    16.696 ? 1174 THR A HG21   1 c 
ATOM   2476 H HG22   . THR A 1 166 ? 10.139  -13.178 6.661   1    16.696 ? 1174 THR A HG22   1 c 
ATOM   2477 H HG23   . THR A 1 166 ? 8.39    -12.861 6.528   1    16.709 ? 1174 THR A HG23   1 c 
ATOM   2478 N N      . GLY A 1 167 ? 9.74    -12.671 11.722  1    14.897 ? 1175 GLY A N      1 ? 
ATOM   2479 C CA     . GLY A 1 167 ? 9.406   -13.051 13.086  1    16.487 ? 1175 GLY A CA     1 ? 
ATOM   2480 C C      . GLY A 1 167 ? 10.442  -13.971 13.71   1    15.336 ? 1175 GLY A C      1 ? 
ATOM   2481 O O      . GLY A 1 167 ? 11.645  -13.703 13.677  1    13.315 ? 1175 GLY A O      1 ? 
ATOM   2482 H H      . GLY A 1 167 ? 9.81    -11.663 11.495  1    16.844 ? 1175 GLY A H      1 ? 
ATOM   2483 H HA2    . GLY A 1 167 ? 9.319   -12.146 13.691  1    15.858 ? 1175 GLY A HA2    1 c 
ATOM   2484 H HA3    . GLY A 1 167 ? 8.433   -13.545 13.089  1    15.846 ? 1175 GLY A HA3    1 c 
ATOM   2485 N N      . THR A 1 168 ? 9.956   -15.064 14.299  1    14.675 ? 1176 THR A N      1 ? 
ATOM   2486 C CA     . THR A 1 168 ? 10.813  -16.008 15.014  1    14.395 ? 1176 THR A CA     1 ? 
ATOM   2487 C C      . THR A 1 168 ? 11.854  -16.661 14.109  1    14.651 ? 1176 THR A C      1 ? 
ATOM   2488 O O      . THR A 1 168 ? 12.791  -17.284 14.617  1    14.013 ? 1176 THR A O      1 ? 
ATOM   2489 C CB     . THR A 1 168 ? 9.983   -17.09  15.708  1    13.967 ? 1176 THR A CB     1 ? 
ATOM   2490 O OG1    . THR A 1 168 ? 9.13    -17.731 14.747  1    14.873 ? 1176 THR A OG1    1 ? 
ATOM   2491 C CG2    . THR A 1 168 ? 9.113   -16.499 16.816  1    13.098 ? 1176 THR A CG2    1 ? 
ATOM   2492 H H      . THR A 1 168 ? 8.946   -15.259 14.228  1    15.11  ? 1176 THR A H      1 ? 
ATOM   2493 H HA     . THR A 1 168 ? 11.344  -15.448 15.787  1    14.415 ? 1176 THR A HA     1 c 
ATOM   2494 H HB     . THR A 1 168 ? 10.653  -17.833 16.145  1    14.049 ? 1176 THR A HB     1 c 
ATOM   2495 H HG1    . THR A 1 168 ? 9.65    -18.288 14.115  1    14.681 ? 1176 THR A HG1    1 ? 
ATOM   2496 H HG21   . THR A 1 168 ? 8.534   -17.295 17.289  1    13.34  ? 1176 THR A HG21   1 c 
ATOM   2497 H HG22   . THR A 1 168 ? 9.749   -16.019 17.563  1    13.34  ? 1176 THR A HG22   1 c 
ATOM   2498 H HG23   . THR A 1 168 ? 8.432   -15.76  16.39   1    13.361 ? 1176 THR A HG23   1 c 
ATOM   2499 N N      . GLY A 1 169 ? 11.693  -16.559 12.792  1    15.605 ? 1177 GLY A N      1 ? 
ATOM   2500 C CA     . GLY A 1 169 ? 12.698  -17.04  11.861  1    15.373 ? 1177 GLY A CA     1 ? 
ATOM   2501 C C      . GLY A 1 169 ? 14.05   -16.368 12.021  1    14.418 ? 1177 GLY A C      1 ? 
ATOM   2502 O O      . GLY A 1 169 ? 15.03   -16.851 11.447  1    13.777 ? 1177 GLY A O      1 ? 
ATOM   2503 H H      . GLY A 1 169 ? 10.936  -15.94  12.451  1    15.161 ? 1177 GLY A H      1 ? 
ATOM   2504 H HA2    . GLY A 1 169 ? 12.816  -18.116 11.998  1    15.206 ? 1177 GLY A HA2    1 c 
ATOM   2505 H HA3    . GLY A 1 169 ? 12.338  -16.877 10.849  1    15.139 ? 1177 GLY A HA3    1 c 
ATOM   2506 N N      . VAL A 1 170 ? 14.131  -15.283 12.804  1    12.862 ? 1178 VAL A N      1 ? 
ATOM   2507 C CA     . VAL A 1 170 ? 15.424  -14.706 13.113  1    14.845 ? 1178 VAL A CA     1 ? 
ATOM   2508 C C      . VAL A 1 170 ? 16.3    -15.651 13.936  1    13.63  ? 1178 VAL A C      1 ? 
ATOM   2509 O O      . VAL A 1 170 ? 17.524  -15.469 13.974  1    13.076 ? 1178 VAL A O      1 ? 
ATOM   2510 C CB     . VAL A 1 170 ? 15.226  -13.364 13.838  1    15.422 ? 1178 VAL A CB     1 ? 
ATOM   2511 C CG1    . VAL A 1 170 ? 14.848  -13.571 15.306  1    15.191 ? 1178 VAL A CG1    1 ? 
ATOM   2512 C CG2    . VAL A 1 170 ? 16.442  -12.48  13.691  1    17.643 ? 1178 VAL A CG2    1 ? 
ATOM   2513 H H      . VAL A 1 170 ? 13.274  -14.826 13.181  1    13.564 ? 1178 VAL A H      1 ? 
ATOM   2514 H HA     . VAL A 1 170 ? 15.935  -14.508 12.169  1    14.323 ? 1178 VAL A HA     1 c 
ATOM   2515 H HB     . VAL A 1 170 ? 14.39   -12.858 13.351  1    15.655 ? 1178 VAL A HB     1 c 
ATOM   2516 H HG11   . VAL A 1 170 ? 15.693  -14.002 15.847  1    15.242 ? 1178 VAL A HG11   1 c 
ATOM   2517 H HG12   . VAL A 1 170 ? 14.586  -12.609 15.753  1    15.249 ? 1178 VAL A HG12   1 c 
ATOM   2518 H HG13   . VAL A 1 170 ? 13.992  -14.245 15.371  1    15.24  ? 1178 VAL A HG13   1 c 
ATOM   2519 H HG21   . VAL A 1 170 ? 17.301  -12.957 14.167  1    16.947 ? 1178 VAL A HG21   1 c 
ATOM   2520 H HG22   . VAL A 1 170 ? 16.655  -12.324 12.631  1    16.968 ? 1178 VAL A HG22   1 c 
ATOM   2521 H HG23   . VAL A 1 170 ? 16.252  -11.517 14.168  1    16.917 ? 1178 VAL A HG23   1 c 
ATOM   2522 N N      . ALA A 1 171 ? 15.714  -16.668 14.572  1    12.958 ? 1179 ALA A N      1 ? 
ATOM   2523 C CA     . ALA A 1 171 ? 16.425  -17.501 15.536  1    12.947 ? 1179 ALA A CA     1 ? 
ATOM   2524 C C      . ALA A 1 171 ? 17.761  -18.061 15.026  1    11.465 ? 1179 ALA A C      1 ? 
ATOM   2525 O O      . ALA A 1 171 ? 18.789  -17.838 15.68   1    10.553 ? 1179 ALA A O      1 ? 
ATOM   2526 C CB     . ALA A 1 171 ? 15.52   -18.647 16.002  1    12.893 ? 1179 ALA A CB     1 ? 
ATOM   2527 H H      . ALA A 1 171 ? 14.708  -16.864 14.406  1    13.64  ? 1179 ALA A H      1 ? 
ATOM   2528 H HA     . ALA A 1 171 ? 16.648  -16.873 16.401  1    12.661 ? 1179 ALA A HA     1 c 
ATOM   2529 H HB1    . ALA A 1 171 ? 16.07   -19.292 16.69   1    12.908 ? 1179 ALA A HB1    1 c 
ATOM   2530 H HB2    . ALA A 1 171 ? 14.645  -18.24  16.511  1    12.908 ? 1179 ALA A HB2    1 c 
ATOM   2531 H HB3    . ALA A 1 171 ? 15.195  -19.235 15.141  1    12.91  ? 1179 ALA A HB3    1 c 
ATOM   2532 N N      . PRO A 1 172 ? 17.813  -18.826 13.929  1    12.39  ? 1180 PRO A N      1 ? 
ATOM   2533 C CA     . PRO A 1 172 ? 19.105  -19.36  13.521  1    11.672 ? 1180 PRO A CA     1 ? 
ATOM   2534 C C      . PRO A 1 172 ? 20.121  -18.263 13.242  1    10.891 ? 1180 PRO A C      1 ? 
ATOM   2535 O O      . PRO A 1 172 ? 21.324  -18.455 13.455  1    9.759  ? 1180 PRO A O      1 ? 
ATOM   2536 C CB     . PRO A 1 172 ? 18.814  -20.148 12.242  1    12.012 ? 1180 PRO A CB     1 ? 
ATOM   2537 C CG     . PRO A 1 172 ? 17.538  -19.543 11.727  1    12.325 ? 1180 PRO A CG     1 ? 
ATOM   2538 C CD     . PRO A 1 172 ? 16.745  -19.207 12.984  1    13.039 ? 1180 PRO A CD     1 ? 
ATOM   2539 H HA     . PRO A 1 172 ? 19.487  -20.029 14.294  1    11.718 ? 1180 PRO A HA     1 c 
ATOM   2540 H HB2    . PRO A 1 172 ? 19.623  -20.029 11.518  1    11.999 ? 1180 PRO A HB2    1 c 
ATOM   2541 H HB3    . PRO A 1 172 ? 18.684  -21.21  12.46   1    12.004 ? 1180 PRO A HB3    1 c 
ATOM   2542 H HG2    . PRO A 1 172 ? 17.739  -18.641 11.145  1    12.406 ? 1180 PRO A HG2    1 c 
ATOM   2543 H HG3    . PRO A 1 172 ? 16.991  -20.254 11.104  1    12.406 ? 1180 PRO A HG3    1 c 
ATOM   2544 H HD2    . PRO A 1 172 ? 16.059  -18.379 12.816  1    12.747 ? 1180 PRO A HD2    1 c 
ATOM   2545 H HD3    . PRO A 1 172 ? 16.19   -20.073 13.351  1    12.74  ? 1180 PRO A HD3    1 c 
ATOM   2546 N N      . PHE A 1 173 ? 19.651  -17.125 12.727  1    11.488 ? 1181 PHE A N      1 ? 
ATOM   2547 C CA     . PHE A 1 173 ? 20.55   -16.049 12.367  1    11.36  ? 1181 PHE A CA     1 ? 
ATOM   2548 C C      . PHE A 1 173 ? 21.159  -15.372 13.595  1    12.472 ? 1181 PHE A C      1 ? 
ATOM   2549 O O      . PHE A 1 173 ? 22.302  -14.904 13.539  1    12.015 ? 1181 PHE A O      1 ? 
ATOM   2550 C CB     . PHE A 1 173 ? 19.824  -15.061 11.452  1    11.719 ? 1181 PHE A CB     1 ? 
ATOM   2551 C CG     . PHE A 1 173 ? 19.145  -15.741 10.286  1    13.138 ? 1181 PHE A CG     1 ? 
ATOM   2552 C CD1    . PHE A 1 173 ? 19.74   -16.805 9.624   1    12.055 ? 1181 PHE A CD1    1 ? 
ATOM   2553 C CD2    . PHE A 1 173 ? 17.896  -15.312 9.861   1    12.559 ? 1181 PHE A CD2    1 ? 
ATOM   2554 C CE1    . PHE A 1 173 ? 19.108  -17.436 8.545   1    12.531 ? 1181 PHE A CE1    1 ? 
ATOM   2555 C CE2    . PHE A 1 173 ? 17.264  -15.94  8.789   1    11.982 ? 1181 PHE A CE2    1 ? 
ATOM   2556 C CZ     . PHE A 1 173 ? 17.864  -16.998 8.129   1    12.541 ? 1181 PHE A CZ     1 ? 
ATOM   2557 H H      . PHE A 1 173 ? 18.622  -17.018 12.598  1    11.026 ? 1181 PHE A H      1 ? 
ATOM   2558 H HA     . PHE A 1 173 ? 21.371  -16.486 11.795  1    11.636 ? 1181 PHE A HA     1 c 
ATOM   2559 H HB2    . PHE A 1 173 ? 19.076  -14.524 12.038  1    11.938 ? 1181 PHE A HB2    1 c 
ATOM   2560 H HB3    . PHE A 1 173 ? 20.548  -14.338 11.072  1    11.944 ? 1181 PHE A HB3    1 c 
ATOM   2561 H HD1    . PHE A 1 173 ? 20.716  -17.151 9.945   1    12.386 ? 1181 PHE A HD1    1 c 
ATOM   2562 H HD2    . PHE A 1 173 ? 17.412  -14.484 10.367  1    12.564 ? 1181 PHE A HD2    1 c 
ATOM   2563 H HE1    . PHE A 1 173 ? 19.592  -18.265 8.039   1    12.428 ? 1181 PHE A HE1    1 c 
ATOM   2564 H HE2    . PHE A 1 173 ? 16.289  -15.593 8.466   1    12.262 ? 1181 PHE A HE2    1 c 
ATOM   2565 H HZ     . PHE A 1 173 ? 17.364  -17.479 7.295   1    12.414 ? 1181 PHE A HZ     1 c 
ATOM   2566 N N      . ARG A 1 174 ? 20.412  -15.294 14.707  1    11.794 ? 1182 ARG A N      1 ? 
ATOM   2567 C CA     . ARG A 1 174 ? 21.038  -14.83  15.938  1    12.135 ? 1182 ARG A CA     1 ? 
ATOM   2568 C C      . ARG A 1 174 ? 22.257  -15.697 16.272  1    12.75  ? 1182 ARG A C      1 ? 
ATOM   2569 O O      . ARG A 1 174 ? 23.313  -15.185 16.657  1    13.17  ? 1182 ARG A O      1 ? 
ATOM   2570 C CB     . ARG A 1 174 ? 20.033  -14.853 17.089  1    12.059 ? 1182 ARG A CB     1 ? 
ATOM   2571 C CG     . ARG A 1 174 ? 20.602  -14.325 18.399  1    12.777 ? 1182 ARG A CG     1 ? 
ATOM   2572 C CD     . ARG A 1 174 ? 19.512  -14.284 19.475  1    12.564 ? 1182 ARG A CD     1 ? 
ATOM   2573 N NE     . ARG A 1 174 ? 20.005  -13.776 20.755  1    13.798 ? 1182 ARG A NE     1 ? 
ATOM   2574 C CZ     . ARG A 1 174 ? 20.517  -14.528 21.729  1    13.047 ? 1182 ARG A CZ     1 ? 
ATOM   2575 N NH1    . ARG A 1 174 ? 20.668  -15.845 21.592  1    12.651 ? 1182 ARG A NH1    1 ? 
ATOM   2576 N NH2    . ARG A 1 174 ? 20.883  -13.946 22.863  1    14.233 ? 1182 ARG A NH2    1 ? 
ATOM   2577 H H      . ARG A 1 174 ? 19.415  -15.593 14.73   1    12.546 ? 1182 ARG A H      1 ? 
ATOM   2578 H HA     . ARG A 1 174 ? 21.374  -13.802 15.785  1    12.162 ? 1182 ARG A HA     1 c 
ATOM   2579 H HB2    . ARG A 1 174 ? 19.165  -14.251 16.813  1    12.229 ? 1182 ARG A HB2    1 c 
ATOM   2580 H HB3    . ARG A 1 174 ? 19.692  -15.88  17.24   1    12.229 ? 1182 ARG A HB3    1 c 
ATOM   2581 H HG2    . ARG A 1 174 ? 21.414  -14.973 18.735  1    12.573 ? 1182 ARG A HG2    1 c 
ATOM   2582 H HG3    . ARG A 1 174 ? 20.998  -13.319 18.247  1    12.572 ? 1182 ARG A HG3    1 c 
ATOM   2583 H HD2    . ARG A 1 174 ? 18.7    -13.643 19.128  1    12.869 ? 1182 ARG A HD2    1 c 
ATOM   2584 H HD3    . ARG A 1 174 ? 19.105  -15.286 19.618  1    12.869 ? 1182 ARG A HD3    1 c 
ATOM   2585 H HE     . ARG A 1 174 ? 19.959  -12.784 20.926  1    14.631 ? 1182 ARG A HE     1 ? 
ATOM   2586 H HH11   . ARG A 1 174 ? 20.495  -16.374 20.769  1    13.693 ? 1182 ARG A HH11   1 ? 
ATOM   2587 H HH12   . ARG A 1 174 ? 21.047  -16.33  22.412  1    13.334 ? 1182 ARG A HH12   1 ? 
ATOM   2588 H HH21   . ARG A 1 174 ? 20.738  -12.957 22.973  1    14.662 ? 1182 ARG A HH21   1 ? 
ATOM   2589 H HH22   . ARG A 1 174 ? 21.311  -14.494 23.603  1    14.71  ? 1182 ARG A HH22   1 ? 
ATOM   2590 N N      . GLY A 1 175 ? 22.11   -17.019 16.131  1    12.617 ? 1183 GLY A N      1 ? 
ATOM   2591 C CA     . GLY A 1 175 ? 23.214  -17.921 16.373  1    11.954 ? 1183 GLY A CA     1 ? 
ATOM   2592 C C      . GLY A 1 175 ? 24.348  -17.759 15.351  1    12.92  ? 1183 GLY A C      1 ? 
ATOM   2593 O O      . GLY A 1 175 ? 25.517  -17.693 15.728  1    12.639 ? 1183 GLY A O      1 ? 
ATOM   2594 H H      . GLY A 1 175 ? 21.189  -17.414 15.857  1    12.087 ? 1183 GLY A H      1 ? 
ATOM   2595 H HA2    . GLY A 1 175 ? 23.603  -17.744 17.378  1    12.306 ? 1183 GLY A HA2    1 c 
ATOM   2596 H HA3    . GLY A 1 175 ? 22.84   -18.947 16.335  1    12.313 ? 1183 GLY A HA3    1 c 
ATOM   2597 N N      . TYR A 1 176 ? 24.011  -17.693 14.052  1    11.402 ? 1184 TYR A N      1 ? 
ATOM   2598 C CA     . TYR A 1 176 ? 25.053  -17.496 13.059  1    12.247 ? 1184 TYR A CA     1 ? 
ATOM   2599 C C      . TYR A 1 176 ? 25.866  -16.247 13.389  1    11.401 ? 1184 TYR A C      1 ? 
ATOM   2600 O O      . TYR A 1 176 ? 27.099  -16.246 13.316  1    10.759 ? 1184 TYR A O      1 ? 
ATOM   2601 C CB     . TYR A 1 176 ? 24.47   -17.247 11.664  1    12.333 ? 1184 TYR A CB     1 ? 
ATOM   2602 C CG     . TYR A 1 176 ? 23.752  -18.38  10.942  1    12.784 ? 1184 TYR A CG     1 ? 
ATOM   2603 C CD1    . TYR A 1 176 ? 23.637  -19.67  11.436  1    13.571 ? 1184 TYR A CD1    1 ? 
ATOM   2604 C CD2    . TYR A 1 176 ? 23.169  -18.1   9.709   1    13.239 ? 1184 TYR A CD2    1 ? 
ATOM   2605 C CE1    . TYR A 1 176 ? 22.955  -20.648 10.723  1    14.936 ? 1184 TYR A CE1    1 ? 
ATOM   2606 C CE2    . TYR A 1 176 ? 22.482  -19.056 9.005   1    14.411 ? 1184 TYR A CE2    1 ? 
ATOM   2607 C CZ     . TYR A 1 176 ? 22.354  -20.332 9.502   1    15.213 ? 1184 TYR A CZ     1 ? 
ATOM   2608 O OH     . TYR A 1 176 ? 21.673  -21.261 8.76    1    16.662 ? 1184 TYR A OH     1 ? 
ATOM   2609 H H      . TYR A 1 176 ? 23.035  -17.892 13.766  1    12.442 ? 1184 TYR A H      1 ? 
ATOM   2610 H HA     . TYR A 1 176 ? 25.709  -18.369 13.035  1    11.947 ? 1184 TYR A HA     1 c 
ATOM   2611 H HB2    . TYR A 1 176 ? 23.775  -16.408 11.744  1    12.41  ? 1184 TYR A HB2    1 c 
ATOM   2612 H HB3    . TYR A 1 176 ? 25.285  -16.905 11.023  1    12.405 ? 1184 TYR A HB3    1 c 
ATOM   2613 H HD1    . TYR A 1 176 ? 24.082  -19.92  12.393  1    13.68  ? 1184 TYR A HD1    1 c 
ATOM   2614 H HD2    . TYR A 1 176 ? 23.235  -17.096 9.308   1    13.442 ? 1184 TYR A HD2    1 c 
ATOM   2615 H HE1    . TYR A 1 176 ? 22.865  -21.651 11.127  1    14.667 ? 1184 TYR A HE1    1 c 
ATOM   2616 H HE2    . TYR A 1 176 ? 22.03   -18.803 8.051   1    14.311 ? 1184 TYR A HE2    1 c 
ATOM   2617 H HH     . TYR A 1 176 ? 21.801  -22.118 9.181   1    14.854 ? 1184 TYR A HH     1 ? 
ATOM   2618 N N      . LEU A 1 177 ? 25.159  -15.143 13.656  1    10.778 ? 1185 LEU A N      1 ? 
ATOM   2619 C CA     . LEU A 1 177 ? 25.811  -13.851 13.754  1    10.745 ? 1185 LEU A CA     1 ? 
ATOM   2620 C C      . LEU A 1 177 ? 26.648  -13.743 15.027  1    11.53  ? 1185 LEU A C      1 ? 
ATOM   2621 O O      . LEU A 1 177 ? 27.716  -13.129 15.009  1    10.175 ? 1185 LEU A O      1 ? 
ATOM   2622 C CB     . LEU A 1 177 ? 24.784  -12.734 13.664  1    11.894 ? 1185 LEU A CB     1 ? 
ATOM   2623 C CG     . LEU A 1 177 ? 24.141  -12.601 12.282  1    12.035 ? 1185 LEU A CG     1 ? 
ATOM   2624 C CD1    . LEU A 1 177 ? 22.882  -11.745 12.352  1    11.53  ? 1185 LEU A CD1    1 ? 
ATOM   2625 C CD2    . LEU A 1 177 ? 25.118  -12.037 11.255  1    12.539 ? 1185 LEU A CD2    1 ? 
ATOM   2626 H H      . LEU A 1 177 ? 24.134  -15.222 13.825  1    10.78  ? 1185 LEU A H      1 ? 
ATOM   2627 H HA     . LEU A 1 177 ? 26.491  -13.763 12.905  1    11.107 ? 1185 LEU A HA     1 c 
ATOM   2628 H HB2    . LEU A 1 177 ? 23.999  -12.925 14.399  1    11.664 ? 1185 LEU A HB2    1 c 
ATOM   2629 H HB3    . LEU A 1 177 ? 25.277  -11.792 13.911  1    11.676 ? 1185 LEU A HB3    1 c 
ATOM   2630 H HG     . LEU A 1 177 ? 23.848  -13.599 11.949  1    12.006 ? 1185 LEU A HG     1 c 
ATOM   2631 H HD11   . LEU A 1 177 ? 22.164  -12.206 13.033  1    11.669 ? 1185 LEU A HD11   1 c 
ATOM   2632 H HD12   . LEU A 1 177 ? 23.138  -10.748 12.717  1    11.669 ? 1185 LEU A HD12   1 c 
ATOM   2633 H HD13   . LEU A 1 177 ? 22.439  -11.664 11.357  1    11.672 ? 1185 LEU A HD13   1 c 
ATOM   2634 H HD21   . LEU A 1 177 ? 25.471  -11.058 11.586  1    12.392 ? 1185 LEU A HD21   1 c 
ATOM   2635 H HD22   . LEU A 1 177 ? 25.968  -12.713 11.149  1    12.383 ? 1185 LEU A HD22   1 c 
ATOM   2636 H HD23   . LEU A 1 177 ? 24.615  -11.934 10.291  1    12.385 ? 1185 LEU A HD23   1 c 
ATOM   2637 N N      . ARG A 1 178 ? 26.211  -14.356 16.125  1    10.928 ? 1186 ARG A N      1 ? 
ATOM   2638 C CA     . ARG A 1 178 ? 27.063  -14.386 17.3    1    11.229 ? 1186 ARG A CA     1 ? 
ATOM   2639 C C      . ARG A 1 178 ? 28.348  -15.162 17.02   1    12.12  ? 1186 ARG A C      1 ? 
ATOM   2640 O O      . ARG A 1 178 ? 29.428  -14.767 17.467  1    12.873 ? 1186 ARG A O      1 ? 
ATOM   2641 C CB     . ARG A 1 178 ? 26.341  -14.985 18.5    1    11.576 ? 1186 ARG A CB     1 ? 
ATOM   2642 C CG     . ARG A 1 178 ? 25.462  -14.006 19.236  1    12.229 ? 1186 ARG A CG     1 ? 
ATOM   2643 C CD     . ARG A 1 178 ? 25.007  -14.566 20.572  1    13.933 ? 1186 ARG A CD     1 ? 
ATOM   2644 N NE     . ARG A 1 178 ? 24.27   -13.542 21.307  1    13.854 ? 1186 ARG A NE     1 ? 
ATOM   2645 C CZ     . ARG A 1 178 ? 24.342  -13.353 22.614  1    13.705 ? 1186 ARG A CZ     1 ? 
ATOM   2646 N NH1    . ARG A 1 178 ? 24.982  -14.202 23.408  1    13.562 ? 1186 ARG A NH1    1 ? 
ATOM   2647 N NH2    . ARG A 1 178 ? 23.76   -12.284 23.135  1    14.425 ? 1186 ARG A NH2    1 ? 
ATOM   2648 H H      . ARG A 1 178 ? 25.331  -14.892 16.122  1    11.044 ? 1186 ARG A H      1 ? 
ATOM   2649 H HA     . ARG A 1 178 ? 27.332  -13.357 17.547  1    11.378 ? 1186 ARG A HA     1 c 
ATOM   2650 H HB2    . ARG A 1 178 ? 25.726  -15.819 18.158  1    11.633 ? 1186 ARG A HB2    1 c 
ATOM   2651 H HB3    . ARG A 1 178 ? 27.084  -15.382 19.195  1    11.641 ? 1186 ARG A HB3    1 c 
ATOM   2652 H HG2    . ARG A 1 178 ? 26.014  -13.079 19.406  1    12.433 ? 1186 ARG A HG2    1 c 
ATOM   2653 H HG3    . ARG A 1 178 ? 24.586  -13.777 18.627  1    12.438 ? 1186 ARG A HG3    1 c 
ATOM   2654 H HD2    . ARG A 1 178 ? 24.365  -15.436 20.415  1    13.532 ? 1186 ARG A HD2    1 c 
ATOM   2655 H HD3    . ARG A 1 178 ? 25.878  -14.879 21.15   1    13.54  ? 1186 ARG A HD3    1 c 
ATOM   2656 H HE     . ARG A 1 178 ? 23.765  -12.844 20.747  1    14.289 ? 1186 ARG A HE     1 ? 
ATOM   2657 H HH11   . ARG A 1 178 ? 25.498  -14.995 23.038  1    13.679 ? 1186 ARG A HH11   1 ? 
ATOM   2658 H HH12   . ARG A 1 178 ? 25.013  -14.019 24.396  1    13.604 ? 1186 ARG A HH12   1 ? 
ATOM   2659 H HH21   . ARG A 1 178 ? 23.247  -11.626 22.535  1    14.151 ? 1186 ARG A HH21   1 ? 
ATOM   2660 H HH22   . ARG A 1 178 ? 23.699  -12.153 24.152  1    13.999 ? 1186 ARG A HH22   1 ? 
ATOM   2661 N N      . ARG A 1 179 ? 28.251  -16.282 16.306  1    12.854 ? 1187 ARG A N      1 ? 
ATOM   2662 C CA     . ARG A 1 179 ? 29.439  -17.049 15.968  1    12.742 ? 1187 ARG A CA     1 ? 
ATOM   2663 C C      . ARG A 1 179 ? 30.358  -16.256 15.026  1    12.946 ? 1187 ARG A C      1 ? 
ATOM   2664 O O      . ARG A 1 179 ? 31.582  -16.3   15.154  1    12.202 ? 1187 ARG A O      1 ? 
ATOM   2665 C CB     . ARG A 1 179 ? 29.033  -18.395 15.367  1    11.989 ? 1187 ARG A CB     1 ? 
ATOM   2666 C CG     . ARG A 1 179 ? 30.2    -19.283 14.979  1    11.401 ? 1187 ARG A CG     1 ? 
ATOM   2667 C CD     . ARG A 1 179 ? 29.702  -20.692 14.694  1    11.981 ? 1187 ARG A CD     1 ? 
ATOM   2668 N NE     . ARG A 1 179 ? 30.749  -21.611 14.236  1    13.488 ? 1187 ARG A NE     1 ? 
ATOM   2669 C CZ     . ARG A 1 179 ? 31.562  -22.288 15.034  1    13.305 ? 1187 ARG A CZ     1 ? 
ATOM   2670 N NH1    . ARG A 1 179 ? 31.541  -22.128 16.354  1    14.976 ? 1187 ARG A NH1    1 ? 
ATOM   2671 N NH2    . ARG A 1 179 ? 32.393  -23.15  14.505  1    13.502 ? 1187 ARG A NH2    1 ? 
ATOM   2672 H H      . ARG A 1 179 ? 27.342  -16.618 15.953  1    12.335 ? 1187 ARG A H      1 ? 
ATOM   2673 H HA     . ARG A 1 179 ? 29.988  -17.244 16.892  1    12.662 ? 1187 ARG A HA     1 c 
ATOM   2674 H HB2    . ARG A 1 179 ? 28.413  -18.927 16.091  1    12.016 ? 1187 ARG A HB2    1 c 
ATOM   2675 H HB3    . ARG A 1 179 ? 28.423  -18.211 14.481  1    12.016 ? 1187 ARG A HB3    1 c 
ATOM   2676 H HG2    . ARG A 1 179 ? 30.686  -18.884 14.087  1    11.658 ? 1187 ARG A HG2    1 c 
ATOM   2677 H HG3    . ARG A 1 179 ? 30.927  -19.313 15.794  1    11.653 ? 1187 ARG A HG3    1 c 
ATOM   2678 H HD2    . ARG A 1 179 ? 29.252  -21.093 15.603  1    12.209 ? 1187 ARG A HD2    1 c 
ATOM   2679 H HD3    . ARG A 1 179 ? 28.919  -20.639 13.934  1    12.182 ? 1187 ARG A HD3    1 c 
ATOM   2680 H HE     . ARG A 1 179 ? 30.757  -21.852 13.253  1    12.816 ? 1187 ARG A HE     1 ? 
ATOM   2681 H HH11   . ARG A 1 179 ? 30.969  -21.43  16.837  1    15.222 ? 1187 ARG A HH11   1 ? 
ATOM   2682 H HH12   . ARG A 1 179 ? 32.048  -22.847 16.86   1    14.984 ? 1187 ARG A HH12   1 ? 
ATOM   2683 H HH21   . ARG A 1 179 ? 32.372  -23.305 13.53   1    13.789 ? 1187 ARG A HH21   1 ? 
ATOM   2684 H HH22   . ARG A 1 179 ? 32.991  -23.648 15.126  1    13.499 ? 1187 ARG A HH22   1 ? 
ATOM   2685 N N      . MET A 1 180 ? 29.77   -15.524 14.085  1    12.98  ? 1188 MET A N      1 ? 
ATOM   2686 C CA     . MET A 1 180 ? 30.529  -14.77  13.1    1    12.406 ? 1188 MET A CA     1 ? 
ATOM   2687 C C      . MET A 1 180 ? 31.236  -13.574 13.743  1    12.413 ? 1188 MET A C      1 ? 
ATOM   2688 O O      . MET A 1 180 ? 32.371  -13.255 13.388  1    13.476 ? 1188 MET A O      1 ? 
ATOM   2689 C CB     . MET A 1 180 ? 29.487  -14.292 12.093  1    11.971 ? 1188 MET A CB     1 ? 
ATOM   2690 C CG     . MET A 1 180 ? 29.237  -15.301 11.026  1    11.468 ? 1188 MET A CG     1 ? 
ATOM   2691 S SD     . MET A 1 180 ? 27.895  -14.743 9.961   1    12.064 ? 1188 MET A SD     1 ? 
ATOM   2692 C CE     . MET A 1 180 ? 27.505  -16.312 9.163   1    11.314 ? 1188 MET A CE     1 ? 
ATOM   2693 H H      . MET A 1 180 ? 28.734  -15.462 14.057  1    13.065 ? 1188 MET A H      1 ? 
ATOM   2694 H HA     . MET A 1 180 ? 31.257  -15.427 12.618  1    12.435 ? 1188 MET A HA     1 c 
ATOM   2695 H HB2    . MET A 1 180 ? 28.554  -14.081 12.617  1    11.952 ? 1188 MET A HB2    1 c 
ATOM   2696 H HB3    . MET A 1 180 ? 29.836  -13.364 11.636  1    11.953 ? 1188 MET A HB3    1 c 
ATOM   2697 H HG2    . MET A 1 180 ? 30.14   -15.441 10.427  1    11.69  ? 1188 MET A HG2    1 c 
ATOM   2698 H HG3    . MET A 1 180 ? 28.968  -16.259 11.476  1    11.69  ? 1188 MET A HG3    1 c 
ATOM   2699 H HE1    . MET A 1 180 ? 28.386  -16.678 8.631   1    11.486 ? 1188 MET A HE1    1 c 
ATOM   2700 H HE2    . MET A 1 180 ? 27.209  -17.041 9.92    1    11.486 ? 1188 MET A HE2    1 c 
ATOM   2701 H HE3    . MET A 1 180 ? 26.686  -16.167 8.456   1    11.486 ? 1188 MET A HE3    1 c 
ATOM   2702 N N      . PHE A 1 181 ? 30.566  -12.903 14.684  1    13.124 ? 1189 PHE A N      1 ? 
ATOM   2703 C CA     . PHE A 1 181 ? 31.006  -11.59  15.141  1    13.122 ? 1189 PHE A CA     1 ? 
ATOM   2704 C C      . PHE A 1 181 ? 31.256  -11.488 16.635  1    14.424 ? 1189 PHE A C      1 ? 
ATOM   2705 O O      . PHE A 1 181 ? 32.163  -10.753 17.038  1    14.165 ? 1189 PHE A O      1 ? 
ATOM   2706 C CB     . PHE A 1 181 ? 29.994  -10.516 14.73   1    12.665 ? 1189 PHE A CB     1 ? 
ATOM   2707 C CG     . PHE A 1 181 ? 29.847  -10.38  13.239  1    12.484 ? 1189 PHE A CG     1 ? 
ATOM   2708 C CD1    . PHE A 1 181 ? 30.945  -10.163 12.441  1    13.567 ? 1189 PHE A CD1    1 ? 
ATOM   2709 C CD2    . PHE A 1 181 ? 28.609  -10.508 12.649  1    13.337 ? 1189 PHE A CD2    1 ? 
ATOM   2710 C CE1    . PHE A 1 181 ? 30.809  -10.043 11.057  1    14.556 ? 1189 PHE A CE1    1 ? 
ATOM   2711 C CE2    . PHE A 1 181 ? 28.467  -10.39  11.271  1    14.095 ? 1189 PHE A CE2    1 ? 
ATOM   2712 C CZ     . PHE A 1 181 ? 29.577  -10.163 10.473  1    13.585 ? 1189 PHE A CZ     1 ? 
ATOM   2713 H H      . PHE A 1 181 ? 29.675  -13.306 15.044  1    12.728 ? 1189 PHE A H      1 ? 
ATOM   2714 H HA     . PHE A 1 181 ? 31.947  -11.364 14.637  1    13.263 ? 1189 PHE A HA     1 c 
ATOM   2715 H HB2    . PHE A 1 181 ? 29.023  -10.767 15.162  1    12.731 ? 1189 PHE A HB2    1 c 
ATOM   2716 H HB3    . PHE A 1 181 ? 30.313  -9.558  15.145  1    12.765 ? 1189 PHE A HB3    1 c 
ATOM   2717 H HD1    . PHE A 1 181 ? 31.926  -10.066 12.896  1    13.523 ? 1189 PHE A HD1    1 c 
ATOM   2718 H HD2    . PHE A 1 181 ? 27.736  -10.686 13.268  1    13.312 ? 1189 PHE A HD2    1 c 
ATOM   2719 H HE1    . PHE A 1 181 ? 31.685  -9.864  10.442  1    14.114 ? 1189 PHE A HE1    1 c 
ATOM   2720 H HE2    . PHE A 1 181 ? 27.485  -10.486 10.82   1    13.806 ? 1189 PHE A HE2    1 c 
ATOM   2721 H HZ     . PHE A 1 181 ? 29.469  -10.073 9.398   1    13.907 ? 1189 PHE A HZ     1 c 
ATOM   2722 N N      . MET A 1 182 ? 30.471  -12.171 17.473  1    13.363 ? 1190 MET A N      1 ? 
ATOM   2723 C CA     . MET A 1 182 ? 30.556  -11.845 18.891  1    13.992 ? 1190 MET A CA     1 ? 
ATOM   2724 C C      . MET A 1 182 ? 31.552  -12.719 19.653  1    13.266 ? 1190 MET A C      1 ? 
ATOM   2725 O O      . MET A 1 182 ? 32.234  -12.212 20.546  1    14.768 ? 1190 MET A O      1 ? 
ATOM   2726 C CB     . MET A 1 182 ? 29.175  -11.668 19.545  1    15.075 ? 1190 MET A CB     1 ? 
ATOM   2727 C CG     . MET A 1 182 ? 29.113  -11.588 21.059  1    15.796 ? 1190 MET A CG     1 ? 
ATOM   2728 S SD     . MET A 1 182 ? 27.5    -11.934 21.801  1    14.756 ? 1190 MET A SD     1 ? 
ATOM   2729 C CE     . MET A 1 182 ? 26.594  -10.57  21.05   1    14.472 ? 1190 MET A CE     1 ? 
ATOM   2730 H H      . MET A 1 182 ? 29.868  -12.939 17.127  1    14.494 ? 1190 MET A H      1 ? 
ATOM   2731 H HA     . MET A 1 182 ? 31.015  -10.855 18.922  1    13.922 ? 1190 MET A HA     1 c 
ATOM   2732 H HB2    . MET A 1 182 ? 28.73   -10.758 19.139  1    15.042 ? 1190 MET A HB2    1 c 
ATOM   2733 H HB3    . MET A 1 182 ? 28.547  -12.501 19.224  1    14.997 ? 1190 MET A HB3    1 c 
ATOM   2734 H HG2    . MET A 1 182 ? 29.833  -12.291 21.479  1    15.415 ? 1190 MET A HG2    1 c 
ATOM   2735 H HG3    . MET A 1 182 ? 29.42   -10.586 21.368  1    15.429 ? 1190 MET A HG3    1 c 
ATOM   2736 H HE1    . MET A 1 182 ? 26.624  -10.668 19.963  1    14.55  ? 1190 MET A HE1    1 c 
ATOM   2737 H HE2    . MET A 1 182 ? 25.556  -10.593 21.389  1    14.547 ? 1190 MET A HE2    1 c 
ATOM   2738 H HE3    . MET A 1 182 ? 27.053  -9.624  21.343  1    14.572 ? 1190 MET A HE3    1 c 
ATOM   2739 N N      . GLU A 1 183 ? 31.654  -14.003 19.32   1    13.998 ? 1191 GLU A N      1 ? 
ATOM   2740 C CA     . GLU A 1 183 ? 32.352  -14.978 20.138  1    13.728 ? 1191 GLU A CA     1 ? 
ATOM   2741 C C      . GLU A 1 183 ? 33.78   -15.198 19.633  1    14.508 ? 1191 GLU A C      1 ? 
ATOM   2742 O O      . GLU A 1 183 ? 34.051  -15.153 18.437  1    13.116 ? 1191 GLU A O      1 ? 
ATOM   2743 C CB     . GLU A 1 183 ? 31.612  -16.314 20.085  1    12.761 ? 1191 GLU A CB     1 ? 
ATOM   2744 C CG     . GLU A 1 183 ? 30.234  -16.256 20.723  1    11.759 ? 1191 GLU A CG     1 ? 
ATOM   2745 C CD     . GLU A 1 183 ? 29.491  -17.568 20.64   1    11.382 ? 1191 GLU A CD     1 ? 
ATOM   2746 O OE1    . GLU A 1 183 ? 29.759  -18.361 19.712  1    11.848 ? 1191 GLU A OE1    1 ? 
ATOM   2747 O OE2    . GLU A 1 183 ? 28.624  -17.796 21.509  1    10.463 ? 1191 GLU A OE2    1 ? 
ATOM   2748 H H      . GLU A 1 183 ? 31.232  -14.323 18.429  1    13.805 ? 1191 GLU A H      1 ? 
ATOM   2749 H HA     . GLU A 1 183 ? 32.385  -14.616 21.168  1    13.742 ? 1191 GLU A HA     1 c 
ATOM   2750 H HB2    . GLU A 1 183 ? 31.512  -16.619 19.041  1    12.731 ? 1191 GLU A HB2    1 c 
ATOM   2751 H HB3    . GLU A 1 183 ? 32.212  -17.07  20.597  1    12.735 ? 1191 GLU A HB3    1 c 
ATOM   2752 H HG2    . GLU A 1 183 ? 30.336  -15.978 21.774  1    11.884 ? 1191 GLU A HG2    1 c 
ATOM   2753 H HG3    . GLU A 1 183 ? 29.641  -15.485 20.228  1    11.884 ? 1191 GLU A HG3    1 c 
ATOM   2754 N N      . ASP A 1 184 ? 34.706  -15.455 20.559  1    13.571 ? 1192 ASP A N      1 ? 
ATOM   2755 C CA     . ASP A 1 184 ? 36.088  -15.717 20.181  1    14.624 ? 1192 ASP A CA     1 ? 
ATOM   2756 C C      . ASP A 1 184 ? 36.249  -17.192 19.827  1    13.71  ? 1192 ASP A C      1 ? 
ATOM   2757 O O      . ASP A 1 184 ? 36.536  -18.029 20.683  1    14.211 ? 1192 ASP A O      1 ? 
ATOM   2758 C CB     . ASP A 1 184 ? 37.04   -15.312 21.298  1    16.803 ? 1192 ASP A CB     1 ? 
ATOM   2759 C CG     . ASP A 1 184 ? 38.5    -15.412 20.892  1    16.478 ? 1192 ASP A CG     1 ? 
ATOM   2760 O OD1    . ASP A 1 184 ? 38.783  -15.656 19.708  1    15.334 ? 1192 ASP A OD1    1 ? 
ATOM   2761 O OD2    . ASP A 1 184 ? 39.329  -15.294 21.81   1    17.484 ? 1192 ASP A OD2    1 ? 
ATOM   2762 H H      . ASP A 1 184 ? 34.44   -15.349 21.554  1    13.615 ? 1192 ASP A H      1 ? 
ATOM   2763 H HA     . ASP A 1 184 ? 36.324  -15.117 19.3    1    14.609 ? 1192 ASP A HA     1 c 
ATOM   2764 H HB2    . ASP A 1 184 ? 36.831  -14.281 21.591  1    16.23  ? 1192 ASP A HB2    1 c 
ATOM   2765 H HB3    . ASP A 1 184 ? 36.875  -15.954 22.165  1    16.222 ? 1192 ASP A HB3    1 c 
ATOM   2766 N N      . VAL A 1 185 ? 36.043  -17.512 18.551  1    12.947 ? 1193 VAL A N      1 ? 
ATOM   2767 C CA     . VAL A 1 185 ? 36.118  -18.875 18.054  1    14.472 ? 1193 VAL A CA     1 ? 
ATOM   2768 C C      . VAL A 1 185 ? 37.345  -18.953 17.153  1    15.401 ? 1193 VAL A C      1 ? 
ATOM   2769 O O      . VAL A 1 185 ? 37.283  -18.581 15.975  1    16.065 ? 1193 VAL A O      1 ? 
ATOM   2770 C CB     . VAL A 1 185 ? 34.851  -19.307 17.305  1    13.766 ? 1193 VAL A CB     1 ? 
ATOM   2771 C CG1    . VAL A 1 185 ? 34.969  -20.749 16.851  1    13.446 ? 1193 VAL A CG1    1 ? 
ATOM   2772 C CG2    . VAL A 1 185 ? 33.635  -19.125 18.205  1    14.924 ? 1193 VAL A CG2    1 ? 
ATOM   2773 H H      . VAL A 1 185 ? 35.795  -16.731 17.913  1    14.205 ? 1193 VAL A H      1 ? 
ATOM   2774 H HA     . VAL A 1 185 ? 36.261  -19.546 18.901  1    14.266 ? 1193 VAL A HA     1 c 
ATOM   2775 H HB     . VAL A 1 185 ? 34.746  -18.664 16.429  1    14.043 ? 1193 VAL A HB     1 c 
ATOM   2776 H HG11   . VAL A 1 185 ? 35.183  -21.386 17.712  1    13.542 ? 1193 VAL A HG11   1 c 
ATOM   2777 H HG12   . VAL A 1 185 ? 34.03   -21.064 16.391  1    13.542 ? 1193 VAL A HG12   1 c 
ATOM   2778 H HG13   . VAL A 1 185 ? 35.778  -20.839 16.123  1    13.568 ? 1193 VAL A HG13   1 c 
ATOM   2779 H HG21   . VAL A 1 185 ? 32.739  -19.461 17.68   1    14.59  ? 1193 VAL A HG21   1 c 
ATOM   2780 H HG22   . VAL A 1 185 ? 33.764  -19.713 19.116  1    14.59  ? 1193 VAL A HG22   1 c 
ATOM   2781 H HG23   . VAL A 1 185 ? 33.528  -18.07  18.467  1    14.579 ? 1193 VAL A HG23   1 c 
ATOM   2782 N N      . PRO A 1 186 ? 38.492  -19.419 17.665  1    17.771 ? 1194 PRO A N      1 ? 
ATOM   2783 C CA     . PRO A 1 186 ? 39.728  -19.253 16.909  1    19.2   ? 1194 PRO A CA     1 ? 
ATOM   2784 C C      . PRO A 1 186 ? 39.741  -19.967 15.57   1    16.568 ? 1194 PRO A C      1 ? 
ATOM   2785 O O      . PRO A 1 186 ? 40.457  -19.542 14.659  1    15.975 ? 1194 PRO A O      1 ? 
ATOM   2786 C CB     . PRO A 1 186 ? 40.765  -19.854 17.855  1    21.335 ? 1194 PRO A CB     1 ? 
ATOM   2787 C CG     . PRO A 1 186 ? 40.192  -19.378 19.173  1    21.243 ? 1194 PRO A CG     1 ? 
ATOM   2788 C CD     . PRO A 1 186 ? 38.806  -19.957 18.998  1    19.866 ? 1194 PRO A CD     1 ? 
ATOM   2789 H HA     . PRO A 1 186 ? 39.929  -18.194 16.762  1    18.793 ? 1194 PRO A HA     1 c 
ATOM   2790 H HB2    . PRO A 1 186 ? 40.782  -20.944 17.792  1    20.84  ? 1194 PRO A HB2    1 c 
ATOM   2791 H HB3    . PRO A 1 186 ? 41.76   -19.441 17.675  1    20.84  ? 1194 PRO A HB3    1 c 
ATOM   2792 H HG2    . PRO A 1 186 ? 40.711  -19.812 20.03   1    20.958 ? 1194 PRO A HG2    1 c 
ATOM   2793 H HG3    . PRO A 1 186 ? 40.175  -18.289 19.248  1    20.958 ? 1194 PRO A HG3    1 c 
ATOM   2794 H HD2    . PRO A 1 186 ? 38.813  -21.049 18.995  1    19.632 ? 1194 PRO A HD2    1 c 
ATOM   2795 H HD3    . PRO A 1 186 ? 38.112  -19.589 19.753  1    19.529 ? 1194 PRO A HD3    1 c 
ATOM   2796 N N      . ASN A 1 187 ? 39.002  -21.064 15.446  1    17.853 ? 1195 ASN A N      1 ? 
ATOM   2797 C CA     . ASN A 1 187 ? 39      -21.86  14.233  1    17.315 ? 1195 ASN A CA     1 ? 
ATOM   2798 C C      . ASN A 1 187 ? 37.949  -21.407 13.211  1    18.367 ? 1195 ASN A C      1 ? 
ATOM   2799 O O      . ASN A 1 187 ? 37.863  -22.016 12.143  1    19.236 ? 1195 ASN A O      1 ? 
ATOM   2800 C CB     . ASN A 1 187 ? 38.795  -23.328 14.589  1    19.098 ? 1195 ASN A CB     1 ? 
ATOM   2801 C CG     . ASN A 1 187 ? 37.546  -23.52  15.417  1    17.886 ? 1195 ASN A CG     1 ? 
ATOM   2802 O OD1    . ASN A 1 187 ? 37.521  -23.151 16.598  1    18.559 ? 1195 ASN A OD1    1 ? 
ATOM   2803 N ND2    . ASN A 1 187 ? 36.524  -24.13  14.838  1    18.929 ? 1195 ASN A ND2    1 ? 
ATOM   2804 H H      . ASN A 1 187 ? 38.464  -21.437 16.247  1    17.408 ? 1195 ASN A H      1 ? 
ATOM   2805 H HA     . ASN A 1 187 ? 39.985  -21.774 13.77   1    17.898 ? 1195 ASN A HA     1 c 
ATOM   2806 H HB2    . ASN A 1 187 ? 38.716  -23.916 13.673  1    18.434 ? 1195 ASN A HB2    1 c 
ATOM   2807 H HB3    . ASN A 1 187 ? 39.659  -23.687 15.151  1    18.43  ? 1195 ASN A HB3    1 c 
ATOM   2808 H HD21   . ASN A 1 187 ? 35.669  -24.316 15.349  1    17.101 ? 1195 ASN A HD21   1 ? 
ATOM   2809 H HD22   . ASN A 1 187 ? 36.677  -24.498 13.899  1    18.434 ? 1195 ASN A HD22   1 ? 
ATOM   2810 N N      . TYR A 1 188 ? 37.17   -20.353 13.505  1    19.301 ? 1196 TYR A N      1 ? 
ATOM   2811 C CA     . TYR A 1 188 ? 36.228  -19.776 12.543  1    17.26  ? 1196 TYR A CA     1 ? 
ATOM   2812 C C      . TYR A 1 188 ? 36.284  -18.25  12.644  1    16.221 ? 1196 TYR A C      1 ? 
ATOM   2813 O O      . TYR A 1 188 ? 35.614  -17.646 13.481  1    17.203 ? 1196 TYR A O      1 ? 
ATOM   2814 C CB     . TYR A 1 188 ? 34.807  -20.296 12.742  1    17.355 ? 1196 TYR A CB     1 ? 
ATOM   2815 C CG     . TYR A 1 188 ? 33.851  -19.801 11.677  1    15.49  ? 1196 TYR A CG     1 ? 
ATOM   2816 C CD1    . TYR A 1 188 ? 33.98   -20.188 10.346  1    13.684 ? 1196 TYR A CD1    1 ? 
ATOM   2817 C CD2    . TYR A 1 188 ? 32.831  -18.919 12.008  1    14.769 ? 1196 TYR A CD2    1 ? 
ATOM   2818 C CE1    . TYR A 1 188 ? 33.096  -19.717 9.378   1    13.864 ? 1196 TYR A CE1    1 ? 
ATOM   2819 C CE2    . TYR A 1 188 ? 31.959  -18.438 11.04   1    15.705 ? 1196 TYR A CE2    1 ? 
ATOM   2820 C CZ     . TYR A 1 188 ? 32.088  -18.844 9.729   1    14.713 ? 1196 TYR A CZ     1 ? 
ATOM   2821 O OH     . TYR A 1 188 ? 31.196  -18.361 8.805   1    14.33  ? 1196 TYR A OH     1 ? 
ATOM   2822 H H      . TYR A 1 188 ? 37.201  -19.908 14.445  1    18.997 ? 1196 TYR A H      1 ? 
ATOM   2823 H HA     . TYR A 1 188 ? 36.554  -20.06  11.54   1    17.461 ? 1196 TYR A HA     1 c 
ATOM   2824 H HB2    . TYR A 1 188 ? 34.827  -21.388 12.725  1    16.907 ? 1196 TYR A HB2    1 c 
ATOM   2825 H HB3    . TYR A 1 188 ? 34.449  -19.974 13.722  1    16.907 ? 1196 TYR A HB3    1 c 
ATOM   2826 H HD1    . TYR A 1 188 ? 34.768  -20.877 10.06   1    14.13  ? 1196 TYR A HD1    1 c 
ATOM   2827 H HD2    . TYR A 1 188 ? 32.718  -18.592 13.037  1    15.121 ? 1196 TYR A HD2    1 c 
ATOM   2828 H HE1    . TYR A 1 188 ? 33.202  -20.035 8.346   1    14.034 ? 1196 TYR A HE1    1 c 
ATOM   2829 H HE2    . TYR A 1 188 ? 31.161  -17.758 11.318  1    15.258 ? 1196 TYR A HE2    1 c 
ATOM   2830 H HH     . TYR A 1 188 ? 31.257  -18.804 7.947   1    12.894 ? 1196 TYR A HH     1 ? 
ATOM   2831 N N      . ARG A 1 189 ? 37.092  -17.649 11.787  1    15.539 ? 1197 ARG A N      1 ? 
ATOM   2832 C CA     . ARG A 1 189 ? 37.272  -16.208 11.72   1    16.671 ? 1197 ARG A CA     1 ? 
ATOM   2833 C C      . ARG A 1 189 ? 36.578  -15.723 10.457  1    17.581 ? 1197 ARG A C      1 ? 
ATOM   2834 O O      . ARG A 1 189 ? 37.093  -15.882 9.355   1    15.16  ? 1197 ARG A O      1 ? 
ATOM   2835 C CB     . ARG A 1 189 ? 38.753  -15.829 11.716  1    18.548 ? 1197 ARG A CB     1 ? 
ATOM   2836 C CG     . ARG A 1 189 ? 39.531  -16.321 12.924  1    18.102 ? 1197 ARG A CG     1 ? 
ATOM   2837 C CD     . ARG A 1 189 ? 38.943  -15.792 14.205  1    19.865 ? 1197 ARG A CD     1 ? 
ATOM   2838 N NE     . ARG A 1 189 ? 39.913  -15.899 15.301  1    19.062 ? 1197 ARG A NE     1 ? 
ATOM   2839 C CZ     . ARG A 1 189 ? 39.64   -15.73  16.587  1    19.408 ? 1197 ARG A CZ     1 ? 
ATOM   2840 N NH1    . ARG A 1 189 ? 38.418  -15.436 16.997  1    17.999 ? 1197 ARG A NH1    1 ? 
ATOM   2841 N NH2    . ARG A 1 189 ? 40.614  -15.851 17.478  1    20.377 ? 1197 ARG A NH2    1 ? 
ATOM   2842 H H      . ARG A 1 189 ? 37.604  -18.212 11.099  1    17.556 ? 1197 ARG A H      1 ? 
ATOM   2843 H HA     . ARG A 1 189 ? 36.791  -15.755 12.586  1    16.957 ? 1197 ARG A HA     1 c 
ATOM   2844 H HB2    . ARG A 1 189 ? 39.214  -16.237 10.813  1    18.007 ? 1197 ARG A HB2    1 c 
ATOM   2845 H HB3    . ARG A 1 189 ? 38.834  -14.742 11.666  1    18.022 ? 1197 ARG A HB3    1 c 
ATOM   2846 H HG2    . ARG A 1 189 ? 39.514  -17.413 12.946  1    18.652 ? 1197 ARG A HG2    1 c 
ATOM   2847 H HG3    . ARG A 1 189 ? 40.57   -15.995 12.844  1    18.59  ? 1197 ARG A HG3    1 c 
ATOM   2848 H HD2    . ARG A 1 189 ? 38.658  -14.746 14.074  1    19.285 ? 1197 ARG A HD2    1 c 
ATOM   2849 H HD3    . ARG A 1 189 ? 38.047  -16.362 14.458  1    19.269 ? 1197 ARG A HD3    1 c 
ATOM   2850 H HE     . ARG A 1 189 ? 40.831  -16.176 15.06   1    19.529 ? 1197 ARG A HE     1 ? 
ATOM   2851 H HH11   . ARG A 1 189 ? 37.693  -15.353 16.294  1    17.108 ? 1197 ARG A HH11   1 ? 
ATOM   2852 H HH12   . ARG A 1 189 ? 38.238  -15.314 17.986  1    17.849 ? 1197 ARG A HH12   1 ? 
ATOM   2853 H HH21   . ARG A 1 189 ? 41.554  -15.938 17.13   1    21.581 ? 1197 ARG A HH21   1 ? 
ATOM   2854 H HH22   . ARG A 1 189 ? 40.508  -15.799 18.477  1    20.374 ? 1197 ARG A HH22   1 ? 
ATOM   2855 N N      . PHE A 1 190 ? 35.384  -15.17  10.628  1    16.542 ? 1198 PHE A N      1 ? 
ATOM   2856 C CA     . PHE A 1 190 ? 34.556  -14.771 9.502   1    15.372 ? 1198 PHE A CA     1 ? 
ATOM   2857 C C      . PHE A 1 190 ? 35.025  -13.443 8.929   1    16.324 ? 1198 PHE A C      1 ? 
ATOM   2858 O O      . PHE A 1 190 ? 35.142  -12.451 9.653   1    17.317 ? 1198 PHE A O      1 ? 
ATOM   2859 C CB     . PHE A 1 190 ? 33.102  -14.657 9.946   1    13.169 ? 1198 PHE A CB     1 ? 
ATOM   2860 C CG     . PHE A 1 190 ? 32.182  -14.29  8.813   1    15.196 ? 1198 PHE A CG     1 ? 
ATOM   2861 C CD1    . PHE A 1 190 ? 31.963  -15.187 7.774   1    14.238 ? 1198 PHE A CD1    1 ? 
ATOM   2862 C CD2    . PHE A 1 190 ? 31.568  -13.045 8.768   1    14.201 ? 1198 PHE A CD2    1 ? 
ATOM   2863 C CE1    . PHE A 1 190 ? 31.144  -14.86  6.714   1    14.361 ? 1198 PHE A CE1    1 ? 
ATOM   2864 C CE2    . PHE A 1 190 ? 30.73   -12.719 7.698   1    15.136 ? 1198 PHE A CE2    1 ? 
ATOM   2865 C CZ     . PHE A 1 190 ? 30.517  -13.625 6.678   1    14.39  ? 1198 PHE A CZ     1 ? 
ATOM   2866 H H      . PHE A 1 190 ? 35.026  -15.074 11.596  1    17.06  ? 1198 PHE A H      1 ? 
ATOM   2867 H HA     . PHE A 1 190 ? 34.627  -15.536 8.729   1    15.332 ? 1198 PHE A HA     1 c 
ATOM   2868 H HB2    . PHE A 1 190 ? 32.787  -15.614 10.368  1    14.057 ? 1198 PHE A HB2    1 c 
ATOM   2869 H HB3    . PHE A 1 190 ? 33.031  -13.896 10.727  1    14.057 ? 1198 PHE A HB3    1 c 
ATOM   2870 H HD1    . PHE A 1 190 ? 32.45   -16.156 7.797   1    14.461 ? 1198 PHE A HD1    1 c 
ATOM   2871 H HD2    . PHE A 1 190 ? 31.731  -12.331 9.569   1    14.6   ? 1198 PHE A HD2    1 c 
ATOM   2872 H HE1    . PHE A 1 190 ? 30.977  -15.578 5.918   1    14.347 ? 1198 PHE A HE1    1 c 
ATOM   2873 H HE2    . PHE A 1 190 ? 30.243  -11.75  7.67    1    14.755 ? 1198 PHE A HE2    1 c 
ATOM   2874 H HZ     . PHE A 1 190 ? 29.867  -13.368 5.849   1    14.53  ? 1198 PHE A HZ     1 c 
ATOM   2875 N N      . GLY A 1 191 ? 35.28   -13.429 7.625   1    16.758 ? 1199 GLY A N      1 ? 
ATOM   2876 C CA     . GLY A 1 191 ? 35.724  -12.226 6.948   1    19.262 ? 1199 GLY A CA     1 ? 
ATOM   2877 C C      . GLY A 1 191 ? 34.919  -11.921 5.7     1    18.035 ? 1199 GLY A C      1 ? 
ATOM   2878 O O      . GLY A 1 191 ? 35.366  -11.146 4.857   1    20.6   ? 1199 GLY A O      1 ? 
ATOM   2879 H H      . GLY A 1 191 ? 35.217  -14.299 7.074   1    15.662 ? 1199 GLY A H      1 ? 
ATOM   2880 H HA2    . GLY A 1 191 ? 35.657  -11.382 7.636   1    18.385 ? 1199 GLY A HA2    1 c 
ATOM   2881 H HA3    . GLY A 1 191 ? 36.774  -12.352 6.674   1    18.443 ? 1199 GLY A HA3    1 c 
ATOM   2882 N N      . GLY A 1 192 ? 33.746  -12.523 5.566   1    16.849 ? 1200 GLY A N      1 ? 
ATOM   2883 C CA     . GLY A 1 192 ? 32.881  -12.295 4.426   1    16.078 ? 1200 GLY A CA     1 ? 
ATOM   2884 C C      . GLY A 1 192 ? 31.856  -11.207 4.693   1    14.927 ? 1200 GLY A C      1 ? 
ATOM   2885 O O      . GLY A 1 192 ? 32.103  -10.255 5.436   1    16.843 ? 1200 GLY A O      1 ? 
ATOM   2886 H H      . GLY A 1 192 ? 33.407  -13.127 6.331   1    16.254 ? 1200 GLY A H      1 ? 
ATOM   2887 H HA2    . GLY A 1 192 ? 33.494  -12.008 3.569   1    16.068 ? 1200 GLY A HA2    1 c 
ATOM   2888 H HA3    . GLY A 1 192 ? 32.371  -13.221 4.169   1    16.023 ? 1200 GLY A HA3    1 c 
ATOM   2889 N N      . LEU A 1 193 ? 30.693  -11.359 4.056   1    14.181 ? 1201 LEU A N      1 ? 
ATOM   2890 C CA     . LEU A 1 193 ? 29.574  -10.449 4.24    1    13.076 ? 1201 LEU A CA     1 ? 
ATOM   2891 C C      . LEU A 1 193 ? 28.391  -11.245 4.765   1    12.813 ? 1201 LEU A C      1 ? 
ATOM   2892 O O      . LEU A 1 193 ? 27.995  -12.24  4.153   1    12.968 ? 1201 LEU A O      1 ? 
ATOM   2893 C CB     . LEU A 1 193 ? 29.199  -9.75   2.928   1    13.251 ? 1201 LEU A CB     1 ? 
ATOM   2894 C CG     . LEU A 1 193 ? 27.896  -8.947  2.961   1    13.644 ? 1201 LEU A CG     1 ? 
ATOM   2895 C CD1    . LEU A 1 193 ? 27.997  -7.776  3.939   1    14.318 ? 1201 LEU A CD1    1 ? 
ATOM   2896 C CD2    . LEU A 1 193 ? 27.466  -8.499  1.593   1    13.75  ? 1201 LEU A CD2    1 ? 
ATOM   2897 H H      . LEU A 1 193 ? 30.572  -12.173 3.428   1    13.995 ? 1201 LEU A H      1 ? 
ATOM   2898 H HA     . LEU A 1 193 ? 29.852  -9.698  4.981   1    13.298 ? 1201 LEU A HA     1 c 
ATOM   2899 H HB2    . LEU A 1 193 ? 30.014  -9.076  2.655   1    13.297 ? 1201 LEU A HB2    1 c 
ATOM   2900 H HB3    . LEU A 1 193 ? 29.117  -10.51  2.148   1    13.297 ? 1201 LEU A HB3    1 c 
ATOM   2901 H HG     . LEU A 1 193 ? 27.111  -9.607  3.336   1    13.706 ? 1201 LEU A HG     1 c 
ATOM   2902 H HD11   . LEU A 1 193 ? 27.085  -7.178  3.889   1    14.122 ? 1201 LEU A HD11   1 c 
ATOM   2903 H HD12   . LEU A 1 193 ? 28.125  -8.158  4.954   1    14.122 ? 1201 LEU A HD12   1 c 
ATOM   2904 H HD13   . LEU A 1 193 ? 28.854  -7.154  3.675   1    14.104 ? 1201 LEU A HD13   1 c 
ATOM   2905 H HD21   . LEU A 1 193 ? 28.242  -7.868  1.154   1    13.726 ? 1201 LEU A HD21   1 c 
ATOM   2906 H HD22   . LEU A 1 193 ? 27.306  -9.372  0.956   1    13.72  ? 1201 LEU A HD22   1 c 
ATOM   2907 H HD23   . LEU A 1 193 ? 26.537  -7.93   1.669   1    13.714 ? 1201 LEU A HD23   1 c 
ATOM   2908 N N      . ALA A 1 194 ? 27.848  -10.81  5.896   1    13.186 ? 1202 ALA A N      1 ? 
ATOM   2909 C CA     . ALA A 1 194 ? 26.606  -11.322 6.438   1    12.772 ? 1202 ALA A CA     1 ? 
ATOM   2910 C C      . ALA A 1 194 ? 25.57   -10.213 6.314   1    14.242 ? 1202 ALA A C      1 ? 
ATOM   2911 O O      . ALA A 1 194 ? 25.824  -9.087  6.737   1    13.471 ? 1202 ALA A O      1 ? 
ATOM   2912 C CB     . ALA A 1 194 ? 26.782  -11.729 7.908   1    11.928 ? 1202 ALA A CB     1 ? 
ATOM   2913 H H      . ALA A 1 194 ? 28.273  -9.974  6.329   1    12.421 ? 1202 ALA A H      1 ? 
ATOM   2914 H HA     . ALA A 1 194 ? 26.284  -12.18  5.848   1    12.963 ? 1202 ALA A HA     1 c 
ATOM   2915 H HB1    . ALA A 1 194 ? 27.088  -10.861 8.495   1    12.162 ? 1202 ALA A HB1    1 c 
ATOM   2916 H HB2    . ALA A 1 194 ? 25.837  -12.113 8.298   1    12.162 ? 1202 ALA A HB2    1 c 
ATOM   2917 H HB3    . ALA A 1 194 ? 27.546  -12.505 7.986   1    12.184 ? 1202 ALA A HB3    1 c 
ATOM   2918 N N      . TRP A 1 195 ? 24.419  -10.523 5.738   1    13.687 ? 1203 TRP A N      1 ? 
ATOM   2919 C CA     . TRP A 1 195 ? 23.408  -9.514  5.462   1    15.212 ? 1203 TRP A CA     1 ? 
ATOM   2920 C C      . TRP A 1 195 ? 22.076  -10.029 5.972   1    14.947 ? 1203 TRP A C      1 ? 
ATOM   2921 O O      . TRP A 1 195 ? 21.516  -10.973 5.402   1    16.186 ? 1203 TRP A O      1 ? 
ATOM   2922 C CB     . TRP A 1 195 ? 23.337  -9.237  3.957   1    14.66  ? 1203 TRP A CB     1 ? 
ATOM   2923 C CG     . TRP A 1 195 ? 22.58   -7.994  3.582   1    14.632 ? 1203 TRP A CG     1 ? 
ATOM   2924 C CD1    . TRP A 1 195 ? 21.692  -7.282  4.339   1    15.534 ? 1203 TRP A CD1    1 ? 
ATOM   2925 C CD2    . TRP A 1 195 ? 22.671  -7.323  2.325   1    15.523 ? 1203 TRP A CD2    1 ? 
ATOM   2926 N NE1    . TRP A 1 195 ? 21.225  -6.206  3.623   1    16.349 ? 1203 TRP A NE1    1 ? 
ATOM   2927 C CE2    . TRP A 1 195 ? 21.819  -6.207  2.387   1    15.768 ? 1203 TRP A CE2    1 ? 
ATOM   2928 C CE3    . TRP A 1 195 ? 23.395  -7.562  1.158   1    15.208 ? 1203 TRP A CE3    1 ? 
ATOM   2929 C CZ2    . TRP A 1 195 ? 21.658  -5.327  1.31    1    15.769 ? 1203 TRP A CZ2    1 ? 
ATOM   2930 C CZ3    . TRP A 1 195 ? 23.262  -6.683  0.099   1    16.582 ? 1203 TRP A CZ3    1 ? 
ATOM   2931 C CH2    . TRP A 1 195 ? 22.384  -5.588  0.175   1    15.59  ? 1203 TRP A CH2    1 ? 
ATOM   2932 H H      . TRP A 1 195 ? 24.245  -11.5   5.451   1    14.509 ? 1203 TRP A H      1 ? 
ATOM   2933 H HA     . TRP A 1 195 ? 23.665  -8.592  5.983   1    14.756 ? 1203 TRP A HA     1 c 
ATOM   2934 H HB2    . TRP A 1 195 ? 24.356  -9.157  3.573   1    14.774 ? 1203 TRP A HB2    1 c 
ATOM   2935 H HB3    . TRP A 1 195 ? 22.869  -10.095 3.468   1    14.78  ? 1203 TRP A HB3    1 c 
ATOM   2936 H HD1    . TRP A 1 195 ? 21.394  -7.515  5.355   1    15.502 ? 1203 TRP A HD1    1 c 
ATOM   2937 H HE1    . TRP A 1 195 ? 20.563  -5.521  3.959   1    16.111 ? 1203 TRP A HE1    1 ? 
ATOM   2938 H HE3    . TRP A 1 195 ? 24.068  -8.41   1.093   1    15.569 ? 1203 TRP A HE3    1 c 
ATOM   2939 H HZ2    . TRP A 1 195 ? 20.993  -4.472  1.375   1    15.747 ? 1203 TRP A HZ2    1 c 
ATOM   2940 H HZ3    . TRP A 1 195 ? 23.815  -6.862  -0.818  1    16.042 ? 1203 TRP A HZ3    1 c 
ATOM   2941 H HH2    . TRP A 1 195 ? 22.295  -4.919  -0.674  1    15.834 ? 1203 TRP A HH2    1 c 
ATOM   2942 N N      . LEU A 1 196 ? 21.583  -9.426  7.048   1    15.308 ? 1204 LEU A N      1 ? 
ATOM   2943 C CA     . LEU A 1 196 ? 20.327  -9.831  7.662   1    14.544 ? 1204 LEU A CA     1 ? 
ATOM   2944 C C      . LEU A 1 196 ? 19.19   -8.929  7.206   1    14.079 ? 1204 LEU A C      1 ? 
ATOM   2945 O O      . LEU A 1 196 ? 19.274  -7.697  7.333   1    13.859 ? 1204 LEU A O      1 ? 
ATOM   2946 C CB     . LEU A 1 196 ? 20.438  -9.781  9.188   1    13.947 ? 1204 LEU A CB     1 ? 
ATOM   2947 C CG     . LEU A 1 196 ? 19.173  -10.079 9.98    1    15.174 ? 1204 LEU A CG     1 ? 
ATOM   2948 C CD1    . LEU A 1 196 ? 18.699  -11.516 9.741   1    14.752 ? 1204 LEU A CD1    1 ? 
ATOM   2949 C CD2    . LEU A 1 196 ? 19.388  -9.822  11.465  1    14.869 ? 1204 LEU A CD2    1 ? 
ATOM   2950 H H      . LEU A 1 196 ? 22.085  -8.623  7.468   1    13.413 ? 1204 LEU A H      1 ? 
ATOM   2951 H HA     . LEU A 1 196 ? 20.108  -10.855 7.355   1    14.508 ? 1204 LEU A HA     1 c 
ATOM   2952 H HB2    . LEU A 1 196 ? 21.208  -10.492 9.495   1    14.338 ? 1204 LEU A HB2    1 c 
ATOM   2953 H HB3    . LEU A 1 196 ? 20.79   -8.786  9.469   1    14.338 ? 1204 LEU A HB3    1 c 
ATOM   2954 H HG     . LEU A 1 196 ? 18.388  -9.404  9.635   1    14.812 ? 1204 LEU A HG     1 c 
ATOM   2955 H HD11   . LEU A 1 196 ? 19.48   -12.214 10.049  1    14.861 ? 1204 LEU A HD11   1 c 
ATOM   2956 H HD12   . LEU A 1 196 ? 17.795  -11.703 10.323  1    14.861 ? 1204 LEU A HD12   1 c 
ATOM   2957 H HD13   . LEU A 1 196 ? 18.484  -11.657 8.68    1    14.841 ? 1204 LEU A HD13   1 c 
ATOM   2958 H HD21   . LEU A 1 196 ? 19.66   -8.776  11.618  1    14.946 ? 1204 LEU A HD21   1 c 
ATOM   2959 H HD22   . LEU A 1 196 ? 18.469  -10.042 12.01   1    14.946 ? 1204 LEU A HD22   1 c 
ATOM   2960 H HD23   . LEU A 1 196 ? 20.192  -10.463 11.834  1    14.924 ? 1204 LEU A HD23   1 c 
ATOM   2961 N N      . PHE A 1 197 ? 18.131  -9.544  6.687   1    14.432 ? 1205 PHE A N      1 ? 
ATOM   2962 C CA     . PHE A 1 197 ? 16.843  -8.92   6.422   1    14.437 ? 1205 PHE A CA     1 ? 
ATOM   2963 C C      . PHE A 1 197 ? 15.827  -9.488  7.411   1    13.962 ? 1205 PHE A C      1 ? 
ATOM   2964 O O      . PHE A 1 197 ? 15.733  -10.704 7.58    1    14.42  ? 1205 PHE A O      1 ? 
ATOM   2965 C CB     . PHE A 1 197 ? 16.334  -9.23   4.998   1    14.796 ? 1205 PHE A CB     1 ? 
ATOM   2966 C CG     . PHE A 1 197 ? 17.125  -8.535  3.892   1    14.507 ? 1205 PHE A CG     1 ? 
ATOM   2967 C CD1    . PHE A 1 197 ? 18.323  -9.056  3.439   1    14.076 ? 1205 PHE A CD1    1 ? 
ATOM   2968 C CD2    . PHE A 1 197 ? 16.638  -7.366  3.299   1    15.362 ? 1205 PHE A CD2    1 ? 
ATOM   2969 C CE1    . PHE A 1 197 ? 19.019  -8.453  2.395   1    14.733 ? 1205 PHE A CE1    1 ? 
ATOM   2970 C CE2    . PHE A 1 197 ? 17.346  -6.726  2.27    1    14.825 ? 1205 PHE A CE2    1 ? 
ATOM   2971 C CZ     . PHE A 1 197 ? 18.54   -7.246  1.829   1    15.196 ? 1205 PHE A CZ     1 ? 
ATOM   2972 H H      . PHE A 1 197 ? 18.189  -10.57  6.583   1    14.751 ? 1205 PHE A H      1 ? 
ATOM   2973 H HA     . PHE A 1 197 ? 16.926  -7.842  6.554   1    14.429 ? 1205 PHE A HA     1 c 
ATOM   2974 H HB2    . PHE A 1 197 ? 16.379  -10.309 4.841   1    14.66  ? 1205 PHE A HB2    1 c 
ATOM   2975 H HB3    . PHE A 1 197 ? 15.289  -8.923  4.93    1    14.685 ? 1205 PHE A HB3    1 c 
ATOM   2976 H HD1    . PHE A 1 197 ? 18.701  -9.977  3.873   1    14.33  ? 1205 PHE A HD1    1 c 
ATOM   2977 H HD2    . PHE A 1 197 ? 15.703  -6.942  3.65    1    15.107 ? 1205 PHE A HD2    1 c 
ATOM   2978 H HE1    . PHE A 1 197 ? 19.965  -8.869  2.065   1    14.687 ? 1205 PHE A HE1    1 c 
ATOM   2979 H HE2    . PHE A 1 197 ? 16.957  -5.813  1.832   1    15.05  ? 1205 PHE A HE2    1 c 
ATOM   2980 H HZ     . PHE A 1 197 ? 19.087  -6.761  1.027   1    15.006 ? 1205 PHE A HZ     1 c 
ATOM   2981 N N      . LEU A 1 198 ? 15.087  -8.597  8.056   1    13.548 ? 1206 LEU A N      1 ? 
ATOM   2982 C CA     . LEU A 1 198 ? 14.11   -8.977  9.065   1    14.815 ? 1206 LEU A CA     1 ? 
ATOM   2983 C C      . LEU A 1 198 ? 12.772  -8.268  8.823   1    15.6   ? 1206 LEU A C      1 ? 
ATOM   2984 O O      . LEU A 1 198 ? 12.703  -7.055  8.946   1    16.702 ? 1206 LEU A O      1 ? 
ATOM   2985 C CB     . LEU A 1 198 ? 14.653  -8.589  10.438  1    14.8   ? 1206 LEU A CB     1 ? 
ATOM   2986 C CG     . LEU A 1 198 ? 13.694  -8.923  11.588  1    15.836 ? 1206 LEU A CG     1 ? 
ATOM   2987 C CD1    . LEU A 1 198 ? 13.332  -10.398 11.586  1    16.399 ? 1206 LEU A CD1    1 ? 
ATOM   2988 C CD2    . LEU A 1 198 ? 14.251  -8.534  12.979  1    16.426 ? 1206 LEU A CD2    1 ? 
ATOM   2989 H H      . LEU A 1 198 ? 15.243  -7.59   7.858   1    14.444 ? 1206 LEU A H      1 ? 
ATOM   2990 H HA     . LEU A 1 198 ? 13.958  -10.056 9.021   1    14.711 ? 1206 LEU A HA     1 c 
ATOM   2991 H HB2    . LEU A 1 198 ? 15.593  -9.121  10.6    1    15.023 ? 1206 LEU A HB2    1 c 
ATOM   2992 H HB3    . LEU A 1 198 ? 14.848  -7.515  10.443  1    15.023 ? 1206 LEU A HB3    1 c 
ATOM   2993 H HG     . LEU A 1 198 ? 12.773  -8.356  11.434  1    15.847 ? 1206 LEU A HG     1 c 
ATOM   2994 H HD11   . LEU A 1 198 ? 12.762  -10.634 10.686  1    16.212 ? 1206 LEU A HD11   1 c 
ATOM   2995 H HD12   . LEU A 1 198 ? 14.244  -10.998 11.607  1    16.229 ? 1206 LEU A HD12   1 c 
ATOM   2996 H HD13   . LEU A 1 198 ? 12.727  -10.625 12.466  1    16.208 ? 1206 LEU A HD13   1 c 
ATOM   2997 H HD21   . LEU A 1 198 ? 15.183  -9.074  13.163  1    16.272 ? 1206 LEU A HD21   1 c 
ATOM   2998 H HD22   . LEU A 1 198 ? 14.442  -7.46   13.008  1    16.321 ? 1206 LEU A HD22   1 c 
ATOM   2999 H HD23   . LEU A 1 198 ? 13.523  -8.794  13.75   1    16.251 ? 1206 LEU A HD23   1 c 
ATOM   3000 N N      . GLY A 1 199 ? 11.701  -9.036  8.573   1    15.857 ? 1207 GLY A N      1 ? 
ATOM   3001 C CA     . GLY A 1 199 ? 10.358  -8.502  8.477   1    16.816 ? 1207 GLY A CA     1 ? 
ATOM   3002 C C      . GLY A 1 199 ? 9.565   -8.865  9.735   1    18.214 ? 1207 GLY A C      1 ? 
ATOM   3003 O O      . GLY A 1 199 ? 9.528   -10.025 10.139  1    17.96  ? 1207 GLY A O      1 ? 
ATOM   3004 H H      . GLY A 1 199 ? 11.814  -10.066 8.522   1    16.911 ? 1207 GLY A H      1 ? 
ATOM   3005 H HA2    . GLY A 1 199 ? 10.402  -7.42   8.36    1    16.904 ? 1207 GLY A HA2    1 c 
ATOM   3006 H HA3    . GLY A 1 199 ? 9.87    -8.923  7.599   1    16.939 ? 1207 GLY A HA3    1 c 
ATOM   3007 N N      . VAL A 1 200 ? 8.987   -7.838  10.363  1    16.981 ? 1208 VAL A N      1 ? 
ATOM   3008 C CA     . VAL A 1 200 ? 8.106   -7.965  11.502  1    19.089 ? 1208 VAL A CA     1 ? 
ATOM   3009 C C      . VAL A 1 200 ? 6.968   -6.933  11.323  1    21.896 ? 1208 VAL A C      1 ? 
ATOM   3010 O O      . VAL A 1 200 ? 7.033   -6.03   10.498  1    21.334 ? 1208 VAL A O      1 ? 
ATOM   3011 C CB     . VAL A 1 200 ? 8.89    -7.682  12.804  1    17.004 ? 1208 VAL A CB     1 ? 
ATOM   3012 C CG1    . VAL A 1 200 ? 9.909   -8.762  13.113  1    17.522 ? 1208 VAL A CG1    1 ? 
ATOM   3013 C CG2    . VAL A 1 200 ? 9.549   -6.296  12.75   1    16.019 ? 1208 VAL A CG2    1 ? 
ATOM   3014 H H      . VAL A 1 200 ? 9.187   -6.882  10.023  1    17.943 ? 1208 VAL A H      1 ? 
ATOM   3015 H HA     . VAL A 1 200 ? 7.689   -8.973  11.532  1    18.737 ? 1208 VAL A HA     1 c 
ATOM   3016 H HB     . VAL A 1 200 ? 8.163   -7.671  13.619  1    17.269 ? 1208 VAL A HB     1 c 
ATOM   3017 H HG11   . VAL A 1 200 ? 10.647  -8.808  12.309  1    17.391 ? 1208 VAL A HG11   1 c 
ATOM   3018 H HG12   . VAL A 1 200 ? 10.412  -8.531  14.054  1    17.388 ? 1208 VAL A HG12   1 c 
ATOM   3019 H HG13   . VAL A 1 200 ? 9.405   -9.727  13.198  1    17.422 ? 1208 VAL A HG13   1 c 
ATOM   3020 H HG21   . VAL A 1 200 ? 8.782   -5.527  12.646  1    16.338 ? 1208 VAL A HG21   1 c 
ATOM   3021 H HG22   . VAL A 1 200 ? 10.11   -6.125  13.672  1    16.34  ? 1208 VAL A HG22   1 c 
ATOM   3022 H HG23   . VAL A 1 200 ? 10.231  -6.248  11.898  1    16.374 ? 1208 VAL A HG23   1 c 
ATOM   3023 N N      . ALA A 1 201 ? 5.949   -7.054  12.158  1    22.679 ? 1209 ALA A N      1 ? 
ATOM   3024 C CA     . ALA A 1 201 ? 4.739   -6.232  12.057  1    22.851 ? 1209 ALA A CA     1 ? 
ATOM   3025 C C      . ALA A 1 201 ? 5.012   -4.772  12.398  1    22.418 ? 1209 ALA A C      1 ? 
ATOM   3026 O O      . ALA A 1 201 ? 4.417   -3.884  11.796  1    23.749 ? 1209 ALA A O      1 ? 
ATOM   3027 C CB     . ALA A 1 201 ? 3.635   -6.807  12.939  1    23.105 ? 1209 ALA A CB     1 ? 
ATOM   3028 H H      . ALA A 1 201 ? 5.991   -7.818  12.857  1    22.37  ? 1209 ALA A H      1 ? 
ATOM   3029 H HA     . ALA A 1 201 ? 4.403   -6.269  11.02   1    22.784 ? 1209 ALA A HA     1 c 
ATOM   3030 H HB1    . ALA A 1 201 ? 2.738   -6.189  12.856  1    23.032 ? 1209 ALA A HB1    1 c 
ATOM   3031 H HB2    . ALA A 1 201 ? 3.402   -7.825  12.62   1    23.032 ? 1209 ALA A HB2    1 c 
ATOM   3032 H HB3    . ALA A 1 201 ? 3.967   -6.823  13.98   1    23.024 ? 1209 ALA A HB3    1 c 
ATOM   3033 N N      . ASN A 1 202 ? 5.892   -4.513  13.377  1    23.652 ? 1210 ASN A N      1 ? 
ATOM   3034 C CA     . ASN A 1 202 ? 6.176   -3.149  13.748  1    23.094 ? 1210 ASN A CA     1 ? 
ATOM   3035 C C      . ASN A 1 202 ? 7.418   -3.099  14.623  1    22.307 ? 1210 ASN A C      1 ? 
ATOM   3036 O O      . ASN A 1 202 ? 8.007   -4.123  14.936  1    22.967 ? 1210 ASN A O      1 ? 
ATOM   3037 C CB     . ASN A 1 202 ? 4.93    -2.472  14.347  1    22.88  ? 1210 ASN A CB     1 ? 
ATOM   3038 C CG     . ASN A 1 202 ? 4.369   -3.166  15.57   1    24.195 ? 1210 ASN A CG     1 ? 
ATOM   3039 O OD1    . ASN A 1 202 ? 5.109   -3.828  16.319  1    26.212 ? 1210 ASN A OD1    1 ? 
ATOM   3040 N ND2    . ASN A 1 202 ? 3.085   -2.986  15.827  1    24.68  ? 1210 ASN A ND2    1 ? 
ATOM   3041 H H      . ASN A 1 202 ? 6.376   -5.278  13.876  1    24.354 ? 1210 ASN A H      1 ? 
ATOM   3042 H HA     . ASN A 1 202 ? 6.41    -2.609  12.83   1    23.008 ? 1210 ASN A HA     1 c 
ATOM   3043 H HB2    . ASN A 1 202 ? 5.193   -1.453  14.625  1    23.186 ? 1210 ASN A HB2    1 c 
ATOM   3044 H HB3    . ASN A 1 202 ? 4.151   -2.416  13.585  1    23.205 ? 1210 ASN A HB3    1 c 
ATOM   3045 H HD21   . ASN A 1 202 ? 2.645   -3.567  16.494  1    23.376 ? 1210 ASN A HD21   1 ? 
ATOM   3046 H HD22   . ASN A 1 202 ? 2.541   -2.328  15.28   1    24.292 ? 1210 ASN A HD22   1 ? 
ATOM   3047 N N      . SER A 1 203 ? 7.794   -1.855  14.961  1    22.558 ? 1211 SER A N      1 ? 
ATOM   3048 C CA     . SER A 1 203 ? 8.975   -1.512  15.745  1    24.859 ? 1211 SER A CA     1 ? 
ATOM   3049 C C      . SER A 1 203 ? 8.991   -2.305  17.055  1    25.722 ? 1211 SER A C      1 ? 
ATOM   3050 O O      . SER A 1 203 ? 10.008  -2.914  17.407  1    25.331 ? 1211 SER A O      1 ? 
ATOM   3051 C CB     . SER A 1 203 ? 8.99    -0.028  16.001  1    25.162 ? 1211 SER A CB     1 ? 
ATOM   3052 O OG     . SER A 1 203 ? 10.32   0.456   16.062  1    29.143 ? 1211 SER A OG     1 ? 
ATOM   3053 H H      . SER A 1 203 ? 7.159   -1.091  14.694  1    21.634 ? 1211 SER A H      1 ? 
ATOM   3054 H HA     . SER A 1 203 ? 9.863   -1.778  15.167  1    24.61  ? 1211 SER A HA     1 c 
ATOM   3055 H HB2    . SER A 1 203 ? 8.458   0.482   15.206  1    25.877 ? 1211 SER A HB2    1 c 
ATOM   3056 H HB3    . SER A 1 203 ? 8.481   0.182   16.943  1    26.054 ? 1211 SER A HB3    1 c 
ATOM   3057 H HG     . SER A 1 203 ? 10.719  0.361   15.178  1    27.904 ? 1211 SER A HG     1 ? 
ATOM   3058 N N      . ASP A 1 204 ? 7.825   -2.349  17.725  1    22.174 ? 1212 ASP A N      1 ? 
ATOM   3059 C CA     . ASP A 1 204 ? 7.665   -3.06   18.982  1    21.463 ? 1212 ASP A CA     1 ? 
ATOM   3060 C C      . ASP A 1 204 ? 7.776   -4.572  18.819  1    20.946 ? 1212 ASP A C      1 ? 
ATOM   3061 O O      . ASP A 1 204 ? 7.97    -5.273  19.818  1    17.849 ? 1212 ASP A O      1 ? 
ATOM   3062 C CB     . ASP A 1 204 ? 6.333   -2.74   19.654  1    23.075 ? 1212 ASP A CB     1 ? 
ATOM   3063 C CG     . ASP A 1 204 ? 6.395   -1.492  20.519  1    21.805 ? 1212 ASP A CG     1 ? 
ATOM   3064 O OD1    . ASP A 1 204 ? 7.43    -0.792  20.516  1    22.145 ? 1212 ASP A OD1    1 ? 
ATOM   3065 O OD2    . ASP A 1 204 ? 5.369   -1.196  21.153  1    23.505 ? 1212 ASP A OD2    1 ? 
ATOM   3066 H H      . ASP A 1 204 ? 6.992   -1.88   17.332  1    22.008 ? 1212 ASP A H      1 ? 
ATOM   3067 H HA     . ASP A 1 204 ? 8.461   -2.735  19.655  1    21.784 ? 1212 ASP A HA     1 c 
ATOM   3068 H HB2    . ASP A 1 204 ? 5.57    -2.595  18.887  1    22.432 ? 1212 ASP A HB2    1 c 
ATOM   3069 H HB3    . ASP A 1 204 ? 6.032   -3.582  20.281  1    22.425 ? 1212 ASP A HB3    1 c 
ATOM   3070 N N      . SER A 1 205 ? 7.667   -5.067  17.57   1    18.659 ? 1213 SER A N      1 ? 
ATOM   3071 C CA     . SER A 1 205 ? 7.792   -6.49   17.319  1    18.113 ? 1213 SER A CA     1 ? 
ATOM   3072 C C      . SER A 1 205 ? 9.203   -6.899  16.915  1    16.173 ? 1213 SER A C      1 ? 
ATOM   3073 O O      . SER A 1 205 ? 9.434   -8.071  16.615  1    15.066 ? 1213 SER A O      1 ? 
ATOM   3074 C CB     . SER A 1 205 ? 6.814   -6.939  16.244  1    18.53  ? 1213 SER A CB     1 ? 
ATOM   3075 O OG     . SER A 1 205 ? 5.481   -6.621  16.612  1    18.991 ? 1213 SER A OG     1 ? 
ATOM   3076 H H      . SER A 1 205 ? 7.543   -4.43   16.767  1    20.587 ? 1213 SER A H      1 ? 
ATOM   3077 H HA     . SER A 1 205 ? 7.543   -7.017  18.242  1    17.938 ? 1213 SER A HA     1 c 
ATOM   3078 H HB2    . SER A 1 205 ? 7.061   -6.449  15.301  1    18.635 ? 1213 SER A HB2    1 c 
ATOM   3079 H HB3    . SER A 1 205 ? 6.903   -8.016  16.104  1    18.654 ? 1213 SER A HB3    1 c 
ATOM   3080 H HG     . SER A 1 205 ? 5.401   -5.629  16.652  1    19.447 ? 1213 SER A HG     1 ? 
ATOM   3081 N N      . LEU A 1 206 ? 10.141  -5.955  16.874  1    17.972 ? 1214 LEU A N      1 ? 
ATOM   3082 C CA     . LEU A 1 206 ? 11.513  -6.296  16.553  1    18.292 ? 1214 LEU A CA     1 ? 
ATOM   3083 C C      . LEU A 1 206 ? 12.097  -7.237  17.609  1    16.707 ? 1214 LEU A C      1 ? 
ATOM   3084 O O      . LEU A 1 206 ? 11.714  -7.212  18.785  1    15.731 ? 1214 LEU A O      1 ? 
ATOM   3085 C CB     . LEU A 1 206 ? 12.362  -5.039  16.407  1    18.927 ? 1214 LEU A CB     1 ? 
ATOM   3086 C CG     . LEU A 1 206 ? 12.164  -4.276  15.082  1    19.57  ? 1214 LEU A CG     1 ? 
ATOM   3087 C CD1    . LEU A 1 206 ? 12.787  -2.88   15.19   1    20.657 ? 1214 LEU A CD1    1 ? 
ATOM   3088 C CD2    . LEU A 1 206 ? 12.745  -5.034  13.891  1    20.661 ? 1214 LEU A CD2    1 ? 
ATOM   3089 H H      . LEU A 1 206 ? 9.927   -4.966  17.092  1    19.058 ? 1214 LEU A H      1 ? 
ATOM   3090 H HA     . LEU A 1 206 ? 11.508  -6.827  15.599  1    18.07  ? 1214 LEU A HA     1 c 
ATOM   3091 H HB2    . LEU A 1 206 ? 12.126  -4.367  17.234  1    18.948 ? 1214 LEU A HB2    1 c 
ATOM   3092 H HB3    . LEU A 1 206 ? 13.413  -5.324  16.488  1    18.9   ? 1214 LEU A HB3    1 c 
ATOM   3093 H HG     . LEU A 1 206 ? 11.092  -4.156  14.915  1    19.837 ? 1214 LEU A HG     1 c 
ATOM   3094 H HD11   . LEU A 1 206 ? 12.642  -2.341  14.251  1    20.35  ? 1214 LEU A HD11   1 c 
ATOM   3095 H HD12   . LEU A 1 206 ? 12.308  -2.328  16.002  1    20.343 ? 1214 LEU A HD12   1 c 
ATOM   3096 H HD13   . LEU A 1 206 ? 13.856  -2.971  15.394  1    20.312 ? 1214 LEU A HD13   1 c 
ATOM   3097 H HD21   . LEU A 1 206 ? 13.817  -5.181  14.04   1    20.382 ? 1214 LEU A HD21   1 c 
ATOM   3098 H HD22   . LEU A 1 206 ? 12.254  -6.005  13.801  1    20.299 ? 1214 LEU A HD22   1 c 
ATOM   3099 H HD23   . LEU A 1 206 ? 12.582  -4.459  12.978  1    20.325 ? 1214 LEU A HD23   1 c 
ATOM   3100 N N      . LEU A 1 207 ? 13.019  -8.08   17.149  1    16.34  ? 1215 LEU A N      1 ? 
ATOM   3101 C CA     . LEU A 1 207 ? 13.608  -9.132  17.965  1    14.809 ? 1215 LEU A CA     1 ? 
ATOM   3102 C C      . LEU A 1 207 ? 15.124  -8.991  17.929  1    14.098 ? 1215 LEU A C      1 ? 
ATOM   3103 O O      . LEU A 1 207 ? 15.727  -9.111  16.858  1    15.718 ? 1215 LEU A O      1 ? 
ATOM   3104 C CB     . LEU A 1 207 ? 13.19   -10.514 17.463  1    14.832 ? 1215 LEU A CB     1 ? 
ATOM   3105 C CG     . LEU A 1 207 ? 11.687  -10.754 17.302  1    13.976 ? 1215 LEU A CG     1 ? 
ATOM   3106 C CD1    . LEU A 1 207 ? 11.425  -12.101 16.607  1    14.136 ? 1215 LEU A CD1    1 ? 
ATOM   3107 C CD2    . LEU A 1 207 ? 10.952  -10.659 18.655  1    15.486 ? 1215 LEU A CD2    1 ? 
ATOM   3108 H H      . LEU A 1 207 ? 13.22   -8.064  16.129  1    16.758 ? 1215 LEU A H      1 ? 
ATOM   3109 H HA     . LEU A 1 207 ? 13.267  -9.007  18.993  1    14.978 ? 1215 LEU A HA     1 c 
ATOM   3110 H HB2    . LEU A 1 207 ? 13.669  -10.682 16.496  1    14.636 ? 1215 LEU A HB2    1 c 
ATOM   3111 H HB3    . LEU A 1 207 ? 13.584  -11.26  18.155  1    14.636 ? 1215 LEU A HB3    1 c 
ATOM   3112 H HG     . LEU A 1 207 ? 11.29   -9.968  16.656  1    14.428 ? 1215 LEU A HG     1 c 
ATOM   3113 H HD11   . LEU A 1 207 ? 10.35   -12.245 16.483  1    14.136 ? 1215 LEU A HD11   1 c 
ATOM   3114 H HD12   . LEU A 1 207 ? 11.907  -12.106 15.628  1    14.102 ? 1215 LEU A HD12   1 c 
ATOM   3115 H HD13   . LEU A 1 207 ? 11.832  -12.911 17.216  1    14.12  ? 1215 LEU A HD13   1 c 
ATOM   3116 H HD21   . LEU A 1 207 ? 9.884   -10.828 18.503  1    15.055 ? 1215 LEU A HD21   1 c 
ATOM   3117 H HD22   . LEU A 1 207 ? 11.346  -11.415 19.338  1    15.055 ? 1215 LEU A HD22   1 c 
ATOM   3118 H HD23   . LEU A 1 207 ? 11.105  -9.667  19.085  1    15.054 ? 1215 LEU A HD23   1 c 
ATOM   3119 N N      . TYR A 1 208 ? 15.738  -8.74   19.096  1    14.504 ? 1216 TYR A N      1 ? 
ATOM   3120 C CA     . TYR A 1 208 ? 17.19   -8.658  19.216  1    14.466 ? 1216 TYR A CA     1 ? 
ATOM   3121 C C      . TYR A 1 208 ? 17.779  -7.475  18.43   1    14.542 ? 1216 TYR A C      1 ? 
ATOM   3122 O O      . TYR A 1 208 ? 18.938  -7.502  18.011  1    13.184 ? 1216 TYR A O      1 ? 
ATOM   3123 C CB     . TYR A 1 208 ? 17.882  -9.963  18.777  1    13.384 ? 1216 TYR A CB     1 ? 
ATOM   3124 C CG     . TYR A 1 208 ? 17.225  -11.23  19.295  1    12.259 ? 1216 TYR A CG     1 ? 
ATOM   3125 C CD1    . TYR A 1 208 ? 17.275  -11.582 20.645  1    11.651 ? 1216 TYR A CD1    1 ? 
ATOM   3126 C CD2    . TYR A 1 208 ? 16.558  -12.079 18.425  1    11.73  ? 1216 TYR A CD2    1 ? 
ATOM   3127 C CE1    . TYR A 1 208 ? 16.693  -12.754 21.108  1    12.08  ? 1216 TYR A CE1    1 ? 
ATOM   3128 C CE2    . TYR A 1 208 ? 15.964  -13.246 18.865  1    12.214 ? 1216 TYR A CE2    1 ? 
ATOM   3129 C CZ     . TYR A 1 208 ? 16.036  -13.588 20.208  1    12.234 ? 1216 TYR A CZ     1 ? 
ATOM   3130 O OH     . TYR A 1 208 ? 15.458  -14.77  20.594  1    12.682 ? 1216 TYR A OH     1 ? 
ATOM   3131 H H      . TYR A 1 208 ? 15.157  -8.57   19.945  1    13.892 ? 1216 TYR A H      1 ? 
ATOM   3132 H HA     . TYR A 1 208 ? 17.42   -8.502  20.271  1    14.373 ? 1216 TYR A HA     1 c 
ATOM   3133 H HB2    . TYR A 1 208 ? 17.9    -9.997  17.687  1    13.366 ? 1216 TYR A HB2    1 c 
ATOM   3134 H HB3    . TYR A 1 208 ? 18.917  -9.938  19.124  1    13.354 ? 1216 TYR A HB3    1 c 
ATOM   3135 H HD1    . TYR A 1 208 ? 17.798  -10.937 21.344  1    11.888 ? 1216 TYR A HD1    1 c 
ATOM   3136 H HD2    . TYR A 1 208 ? 16.507  -11.826 17.371  1    11.96  ? 1216 TYR A HD2    1 c 
ATOM   3137 H HE1    . TYR A 1 208 ? 16.752  -13.019 22.158  1    12.03  ? 1216 TYR A HE1    1 c 
ATOM   3138 H HE2    . TYR A 1 208 ? 15.46   -13.901 18.163  1    12.114 ? 1216 TYR A HE2    1 c 
ATOM   3139 H HH     . TYR A 1 208 ? 15.538  -14.804 21.558  1    13.181 ? 1216 TYR A HH     1 ? 
ATOM   3140 N N      . ASP A 1 209 ? 16.989  -6.416  18.231  1    15.489 ? 1217 ASP A N      1 ? 
ATOM   3141 C CA     . ASP A 1 209 ? 17.408  -5.323  17.362  1    15.044 ? 1217 ASP A CA     1 ? 
ATOM   3142 C C      . ASP A 1 209 ? 18.697  -4.662  17.861  1    16.532 ? 1217 ASP A C      1 ? 
ATOM   3143 O O      . ASP A 1 209 ? 19.557  -4.275  17.062  1    14.678 ? 1217 ASP A O      1 ? 
ATOM   3144 C CB     . ASP A 1 209 ? 16.297  -4.299  17.255  1    15.634 ? 1217 ASP A CB     1 ? 
ATOM   3145 C CG     . ASP A 1 209 ? 16.627  -3.15   16.316  1    17.425 ? 1217 ASP A CG     1 ? 
ATOM   3146 O OD1    . ASP A 1 209 ? 16.921  -3.412  15.127  1    15.932 ? 1217 ASP A OD1    1 ? 
ATOM   3147 O OD2    . ASP A 1 209 ? 16.589  -1.982  16.772  1    16.716 ? 1217 ASP A OD2    1 ? 
ATOM   3148 H H      . ASP A 1 209 ? 16.069  -6.371  18.695  1    15.426 ? 1217 ASP A H      1 ? 
ATOM   3149 H HA     . ASP A 1 209 ? 17.59   -5.73   16.365  1    15.55  ? 1217 ASP A HA     1 c 
ATOM   3150 H HB2    . ASP A 1 209 ? 15.391  -4.791  16.896  1    15.963 ? 1217 ASP A HB2    1 c 
ATOM   3151 H HB3    . ASP A 1 209 ? 16.092  -3.889  18.246  1    15.893 ? 1217 ASP A HB3    1 c 
ATOM   3152 N N      . GLU A 1 210 ? 18.836  -4.488  19.184  1    17.449 ? 1218 GLU A N      1 ? 
ATOM   3153 C CA     . GLU A 1 210 ? 20.026  -3.838  19.702  1    18.742 ? 1218 GLU A CA     1 ? 
ATOM   3154 C C      . GLU A 1 210 ? 21.281  -4.647  19.381  1    16.961 ? 1218 GLU A C      1 ? 
ATOM   3155 O O      . GLU A 1 210 ? 22.334  -4.082  19.078  1    19.009 ? 1218 GLU A O      1 ? 
ATOM   3156 C CB     . GLU A 1 210 ? 19.89   -3.656  21.218  1    23.085 ? 1218 GLU A CB     1 ? 
ATOM   3157 C CG     . GLU A 1 210 ? 20.318  -2.296  21.762  1    29.66  ? 1218 GLU A CG     1 ? 
ATOM   3158 C CD     . GLU A 1 210 ? 20.446  -2.414  23.287  1    37.279 ? 1218 GLU A CD     1 ? 
ATOM   3159 O OE1    . GLU A 1 210 ? 20.35   -3.566  23.773  1    37.044 ? 1218 GLU A OE1    1 ? 
ATOM   3160 O OE2    . GLU A 1 210 ? 20.621  -1.395  23.997  1    40.077 ? 1218 GLU A OE2    1 ? 
ATOM   3161 H H      . GLU A 1 210 ? 18.115  -4.832  19.844  1    19.048 ? 1218 GLU A H      1 ? 
ATOM   3162 H HA     . GLU A 1 210 ? 20.112  -2.856  19.233  1    18.846 ? 1218 GLU A HA     1 c 
ATOM   3163 H HB2    . GLU A 1 210 ? 18.849  -3.816  21.498  1    23.343 ? 1218 GLU A HB2    1 c 
ATOM   3164 H HB3    . GLU A 1 210 ? 20.485  -4.428  21.708  1    23.415 ? 1218 GLU A HB3    1 c 
ATOM   3165 H HG2    . GLU A 1 210 ? 21.278  -2.005  21.335  1    29.61  ? 1218 GLU A HG2    1 c 
ATOM   3166 H HG3    . GLU A 1 210 ? 19.567  -1.545  21.522  1    29.846 ? 1218 GLU A HG3    1 c 
ATOM   3167 N N      . GLU A 1 211 ? 21.184  -5.976  19.463  1    16.771 ? 1219 GLU A N      1 ? 
ATOM   3168 C CA     . GLU A 1 211 ? 22.32   -6.831  19.153  1    14.499 ? 1219 GLU A CA     1 ? 
ATOM   3169 C C      . GLU A 1 211 ? 22.728  -6.66   17.689  1    14.068 ? 1219 GLU A C      1 ? 
ATOM   3170 O O      . GLU A 1 211 ? 23.908  -6.499  17.368  1    14.733 ? 1219 GLU A O      1 ? 
ATOM   3171 C CB     . GLU A 1 211 ? 21.936  -8.281  19.444  1    15.02  ? 1219 GLU A CB     1 ? 
ATOM   3172 C CG     . GLU A 1 211 ? 23.065  -9.261  19.21   1    13.995 ? 1219 GLU A CG     1 ? 
ATOM   3173 C CD     . GLU A 1 211 ? 22.924  -10.499 20.082  1    14.687 ? 1219 GLU A CD     1 ? 
ATOM   3174 O OE1    . GLU A 1 211 ? 22.882  -10.313 21.32   1    13.231 ? 1219 GLU A OE1    1 ? 
ATOM   3175 O OE2    . GLU A 1 211 ? 22.933  -11.645 19.559  1    13.862 ? 1219 GLU A OE2    1 ? 
ATOM   3176 H H      . GLU A 1 211 ? 20.268  -6.388  19.741  1    16.022 ? 1219 GLU A H      1 ? 
ATOM   3177 H HA     . GLU A 1 211 ? 23.157  -6.541  19.791  1    14.916 ? 1219 GLU A HA     1 c 
ATOM   3178 H HB2    . GLU A 1 211 ? 21.604  -8.354  20.481  1    14.665 ? 1219 GLU A HB2    1 c 
ATOM   3179 H HB3    . GLU A 1 211 ? 21.095  -8.557  18.806  1    14.664 ? 1219 GLU A HB3    1 c 
ATOM   3180 H HG2    . GLU A 1 211 ? 23.071  -9.565  18.161  1    14.363 ? 1219 GLU A HG2    1 c 
ATOM   3181 H HG3    . GLU A 1 211 ? 24.018  -8.777  19.432  1    14.363 ? 1219 GLU A HG3    1 c 
ATOM   3182 N N      . PHE A 1 212 ? 21.755  -6.714  16.779  1    14.329 ? 1220 PHE A N      1 ? 
ATOM   3183 C CA     . PHE A 1 212 ? 22.076  -6.594  15.359  1    15.607 ? 1220 PHE A CA     1 ? 
ATOM   3184 C C      . PHE A 1 212 ? 22.606  -5.197  15.033  1    16.808 ? 1220 PHE A C      1 ? 
ATOM   3185 O O      . PHE A 1 212 ? 23.57   -5.052  14.267  1    17.659 ? 1220 PHE A O      1 ? 
ATOM   3186 C CB     . PHE A 1 212 ? 20.852  -6.946  14.52   1    13.716 ? 1220 PHE A CB     1 ? 
ATOM   3187 C CG     . PHE A 1 212 ? 20.343  -8.339  14.783  1    15.147 ? 1220 PHE A CG     1 ? 
ATOM   3188 C CD1    . PHE A 1 212 ? 21.224  -9.409  14.997  1    14.574 ? 1220 PHE A CD1    1 ? 
ATOM   3189 C CD2    . PHE A 1 212 ? 18.976  -8.582  14.842  1    14.034 ? 1220 PHE A CD2    1 ? 
ATOM   3190 C CE1    . PHE A 1 212 ? 20.732  -10.676 15.245  1    14.81  ? 1220 PHE A CE1    1 ? 
ATOM   3191 C CE2    . PHE A 1 212 ? 18.496  -9.86   15.087  1    13.745 ? 1220 PHE A CE2    1 ? 
ATOM   3192 C CZ     . PHE A 1 212 ? 19.374  -10.9   15.287  1    14.936 ? 1220 PHE A CZ     1 ? 
ATOM   3193 H H      . PHE A 1 212 ? 20.77   -6.87   17.06   1    14.995 ? 1220 PHE A H      1 ? 
ATOM   3194 H HA     . PHE A 1 212 ? 22.864  -7.313  15.13   1    15.198 ? 1220 PHE A HA     1 c 
ATOM   3195 H HB2    . PHE A 1 212 ? 20.058  -6.228  14.739  1    14.419 ? 1220 PHE A HB2    1 c 
ATOM   3196 H HB3    . PHE A 1 212 ? 21.113  -6.855  13.463  1    14.419 ? 1220 PHE A HB3    1 c 
ATOM   3197 H HD1    . PHE A 1 212 ? 22.296  -9.243  14.96   1    14.744 ? 1220 PHE A HD1    1 c 
ATOM   3198 H HD2    . PHE A 1 212 ? 18.279  -7.766  14.682  1    14.318 ? 1220 PHE A HD2    1 c 
ATOM   3199 H HE1    . PHE A 1 212 ? 21.421  -11.5   15.401  1    14.764 ? 1220 PHE A HE1    1 c 
ATOM   3200 H HE2    . PHE A 1 212 ? 17.426  -10.038 15.125  1    14.114 ? 1220 PHE A HE2    1 c 
ATOM   3201 H HZ     . PHE A 1 212 ? 18.995  -11.898 15.483  1    14.633 ? 1220 PHE A HZ     1 c 
ATOM   3202 N N      . THR A 1 213 ? 21.995  -4.16   15.607  1    16.421 ? 1221 THR A N      1 ? 
ATOM   3203 C CA     . THR A 1 213 ? 22.489  -2.819  15.349  1    19.403 ? 1221 THR A CA     1 ? 
ATOM   3204 C C      . THR A 1 213 ? 23.93   -2.661  15.837  1    17.814 ? 1221 THR A C      1 ? 
ATOM   3205 O O      . THR A 1 213 ? 24.73   -1.966  15.203  1    18.125 ? 1221 THR A O      1 ? 
ATOM   3206 C CB     . THR A 1 213 ? 21.549  -1.795  15.985  1    21.512 ? 1221 THR A CB     1 ? 
ATOM   3207 O OG1    . THR A 1 213 ? 20.256  -1.911  15.388  1    20.137 ? 1221 THR A OG1    1 ? 
ATOM   3208 C CG2    . THR A 1 213 ? 22.076  -0.388  15.797  1    23.94  ? 1221 THR A CG2    1 ? 
ATOM   3209 H H      . THR A 1 213 ? 21.181  -4.299  16.232  1    17.055 ? 1221 THR A H      1 ? 
ATOM   3210 H HA     . THR A 1 213 ? 22.477  -2.662  14.269  1    18.857 ? 1221 THR A HA     1 c 
ATOM   3211 H HB     . THR A 1 213 ? 21.468  -1.998  17.055  1    21.264 ? 1221 THR A HB     1 c 
ATOM   3212 H HG1    . THR A 1 213 ? 19.739  -1.097  15.332  1    21.321 ? 1221 THR A HG1    1 ? 
ATOM   3213 H HG21   . THR A 1 213 ? 22.264  -0.208  14.736  1    23.2   ? 1221 THR A HG21   1 c 
ATOM   3214 H HG22   . THR A 1 213 ? 21.338  0.33    16.16   1    23.2   ? 1221 THR A HG22   1 c 
ATOM   3215 H HG23   . THR A 1 213 ? 23.006  -0.265  16.355  1    23.089 ? 1221 THR A HG23   1 c 
ATOM   3216 N N      . SER A 1 214 ? 24.29   -3.33   16.938  1    18.617 ? 1222 SER A N      1 ? 
ATOM   3217 C CA     . SER A 1 214 ? 25.658  -3.25   17.436  1    20.529 ? 1222 SER A CA     1 ? 
ATOM   3218 C C      . SER A 1 214 ? 26.653  -3.802  16.427  1    18.104 ? 1222 SER A C      1 ? 
ATOM   3219 O O      . SER A 1 214 ? 27.768  -3.277  16.289  1    19.131 ? 1222 SER A O      1 ? 
ATOM   3220 C CB     . SER A 1 214 ? 25.848  -3.924  18.76   1    27.205 ? 1222 SER A CB     1 ? 
ATOM   3221 O OG     . SER A 1 214 ? 25.338  -3.06   19.771  1    30.426 ? 1222 SER A OG     1 ? 
ATOM   3222 H H      . SER A 1 214 ? 23.567  -3.826  17.494  1    20.724 ? 1222 SER A H      1 ? 
ATOM   3223 H HA     . SER A 1 214 ? 25.888  -2.192  17.572  1    20.799 ? 1222 SER A HA     1 c 
ATOM   3224 H HB2    . SER A 1 214 ? 25.309  -4.874  18.774  1    26.152 ? 1222 SER A HB2    1 c 
ATOM   3225 H HB3    . SER A 1 214 ? 26.91   -4.114  18.931  1    26.178 ? 1222 SER A HB3    1 c 
ATOM   3226 H HG     . SER A 1 214 ? 24.38   -3.159  19.82   1    30.283 ? 1222 SER A HG     1 ? 
ATOM   3227 N N      . TYR A 1 215 ? 26.27   -4.858  15.703  1    16.474 ? 1223 TYR A N      1 ? 
ATOM   3228 C CA     . TYR A 1 215 ? 27.177  -5.398  14.7    1    16.308 ? 1223 TYR A CA     1 ? 
ATOM   3229 C C      . TYR A 1 215 ? 27.452  -4.394  13.584  1    13.682 ? 1223 TYR A C      1 ? 
ATOM   3230 O O      . TYR A 1 215 ? 28.535  -4.42   12.995  1    13.677 ? 1223 TYR A O      1 ? 
ATOM   3231 C CB     . TYR A 1 215 ? 26.624  -6.678  14.07   1    15.044 ? 1223 TYR A CB     1 ? 
ATOM   3232 C CG     . TYR A 1 215 ? 26.444  -7.85   15.02   1    16.073 ? 1223 TYR A CG     1 ? 
ATOM   3233 C CD1    . TYR A 1 215 ? 27.359  -8.157  16.018  1    14.202 ? 1223 TYR A CD1    1 ? 
ATOM   3234 C CD2    . TYR A 1 215 ? 25.339  -8.678  14.868  1    16.522 ? 1223 TYR A CD2    1 ? 
ATOM   3235 C CE1    . TYR A 1 215 ? 27.172  -9.253  16.848  1    14.271 ? 1223 TYR A CE1    1 ? 
ATOM   3236 C CE2    . TYR A 1 215 ? 25.147  -9.778  15.678  1    14.683 ? 1223 TYR A CE2    1 ? 
ATOM   3237 C CZ     . TYR A 1 215 ? 26.064  -10.068 16.677  1    14.289 ? 1223 TYR A CZ     1 ? 
ATOM   3238 O OH     . TYR A 1 215 ? 25.899  -11.163 17.499  1    13.856 ? 1223 TYR A OH     1 ? 
ATOM   3239 H H      . TYR A 1 215 ? 25.331  -5.287  15.804  1    15.235 ? 1223 TYR A H      1 ? 
ATOM   3240 H HA     . TYR A 1 215 ? 28.123  -5.636  15.189  1    15.597 ? 1223 TYR A HA     1 c 
ATOM   3241 H HB2    . TYR A 1 215 ? 25.658  -6.446  13.619  1    15.539 ? 1223 TYR A HB2    1 c 
ATOM   3242 H HB3    . TYR A 1 215 ? 27.297  -6.982  13.265  1    15.536 ? 1223 TYR A HB3    1 c 
ATOM   3243 H HD1    . TYR A 1 215 ? 28.233  -7.529  16.153  1    14.633 ? 1223 TYR A HD1    1 c 
ATOM   3244 H HD2    . TYR A 1 215 ? 24.62   -8.466  14.084  1    15.956 ? 1223 TYR A HD2    1 c 
ATOM   3245 H HE1    . TYR A 1 215 ? 27.897  -9.479  17.623  1    14.363 ? 1223 TYR A HE1    1 c 
ATOM   3246 H HE2    . TYR A 1 215 ? 24.276  -10.409 15.541  1    14.961 ? 1223 TYR A HE2    1 c 
ATOM   3247 H HH     . TYR A 1 215 ? 25.068  -11.569 17.224  1    13.041 ? 1223 TYR A HH     1 ? 
ATOM   3248 N N      . LEU A 1 216 ? 26.486  -3.531  13.254  1    16.37  ? 1224 LEU A N      1 ? 
ATOM   3249 C CA     . LEU A 1 216 ? 26.732  -2.513  12.229  1    16.127 ? 1224 LEU A CA     1 ? 
ATOM   3250 C C      . LEU A 1 216 ? 27.887  -1.597  12.63   1    16.96  ? 1224 LEU A C      1 ? 
ATOM   3251 O O      . LEU A 1 216 ? 28.641  -1.13   11.774  1    15.243 ? 1224 LEU A O      1 ? 
ATOM   3252 C CB     . LEU A 1 216 ? 25.495  -1.655  11.987  1    15.528 ? 1224 LEU A CB     1 ? 
ATOM   3253 C CG     . LEU A 1 216 ? 24.332  -2.29   11.234  1    16.561 ? 1224 LEU A CG     1 ? 
ATOM   3254 C CD1    . LEU A 1 216 ? 23.097  -1.379  11.304  1    15.326 ? 1224 LEU A CD1    1 ? 
ATOM   3255 C CD2    . LEU A 1 216 ? 24.708  -2.62   9.782   1    15.699 ? 1224 LEU A CD2    1 ? 
ATOM   3256 H H      . LEU A 1 216 ? 25.549  -3.603  13.687  1    15.874 ? 1224 LEU A H      1 ? 
ATOM   3257 H HA     . LEU A 1 216 ? 27.001  -3.022  11.301  1    16.204 ? 1224 LEU A HA     1 c 
ATOM   3258 H HB2    . LEU A 1 216 ? 25.127  -1.312  12.956  1    15.896 ? 1224 LEU A HB2    1 c 
ATOM   3259 H HB3    . LEU A 1 216 ? 25.807  -0.764  11.439  1    15.889 ? 1224 LEU A HB3    1 c 
ATOM   3260 H HG     . LEU A 1 216 ? 24.08   -3.228  11.733  1    15.99  ? 1224 LEU A HG     1 c 
ATOM   3261 H HD11   . LEU A 1 216 ? 22.27   -1.843  10.762  1    15.656 ? 1224 LEU A HD11   1 c 
ATOM   3262 H HD12   . LEU A 1 216 ? 22.81   -1.231  12.347  1    15.656 ? 1224 LEU A HD12   1 c 
ATOM   3263 H HD13   . LEU A 1 216 ? 23.33   -0.413  10.851  1    15.653 ? 1224 LEU A HD13   1 c 
ATOM   3264 H HD21   . LEU A 1 216 ? 23.846  -3.055  9.272   1    15.93  ? 1224 LEU A HD21   1 c 
ATOM   3265 H HD22   . LEU A 1 216 ? 25.011  -1.707  9.267   1    15.93  ? 1224 LEU A HD22   1 c 
ATOM   3266 H HD23   . LEU A 1 216 ? 25.534  -3.334  9.772   1    15.923 ? 1224 LEU A HD23   1 c 
ATOM   3267 N N      . LYS A 1 217 ? 28.013  -1.321  13.928  1    18.209 ? 1225 LYS A N      1 ? 
ATOM   3268 C CA     . LYS A 1 217 ? 29.046  -0.421  14.42   1    19.234 ? 1225 LYS A CA     1 ? 
ATOM   3269 C C      . LYS A 1 217 ? 30.372  -1.134  14.654  1    19.685 ? 1225 LYS A C      1 ? 
ATOM   3270 O O      . LYS A 1 217 ? 31.433  -0.513  14.552  1    20.33  ? 1225 LYS A O      1 ? 
ATOM   3271 C CB     . LYS A 1 217 ? 28.584  0.264   15.71   1    23.254 ? 1225 LYS A CB     1 ? 
ATOM   3272 C CG     . LYS A 1 217 ? 27.156  0.838   15.834  1    30.135 ? 1225 LYS A CG     1 ? 
ATOM   3273 C CD     . LYS A 1 217 ? 27.078  2.347   16.125  1    39.714 ? 1225 LYS A CD     1 ? 
ATOM   3274 C CE     . LYS A 1 217 ? 26.376  2.852   17.393  1    46.91  ? 1225 LYS A CE     1 ? 
ATOM   3275 N NZ     . LYS A 1 217 ? 24.942  2.571   17.547  1    47.974 ? 1225 LYS A NZ     1 ? 
ATOM   3276 H H      . LYS A 1 217 ? 27.42   -1.813  14.618  1    17.175 ? 1225 LYS A H      1 ? 
ATOM   3277 H HA     . LYS A 1 217 ? 29.204  0.354   13.667  1    19.74  ? 1225 LYS A HA     1 c 
ATOM   3278 H HB2    . LYS A 1 217 ? 28.713  -0.458  16.519  1    23.622 ? 1225 LYS A HB2    1 c 
ATOM   3279 H HB3    . LYS A 1 217 ? 29.281  1.081   15.906  1    23.708 ? 1225 LYS A HB3    1 c 
ATOM   3280 H HG2    . LYS A 1 217 ? 26.623  0.634   14.903  1    30.154 ? 1225 LYS A HG2    1 c 
ATOM   3281 H HG3    . LYS A 1 217 ? 26.638  0.3     16.631  1    30.225 ? 1225 LYS A HG3    1 c 
ATOM   3282 H HD2    . LYS A 1 217 ? 28.101  2.728   16.136  1    38.578 ? 1225 LYS A HD2    1 c 
ATOM   3283 H HD3    . LYS A 1 217 ? 26.595  2.816   15.265  1    38.719 ? 1225 LYS A HD3    1 c 
ATOM   3284 H HE2    . LYS A 1 217 ? 26.894  2.424   18.254  1    45.477 ? 1225 LYS A HE2    1 c 
ATOM   3285 H HE3    . LYS A 1 217 ? 26.514  3.933   17.445  1    45.478 ? 1225 LYS A HE3    1 c 
ATOM   3286 H HZ1    . LYS A 1 217 ? 24.433  3.143   16.881  1    47.463 ? 1225 LYS A HZ1    1 ? 
ATOM   3287 H HZ2    . LYS A 1 217 ? 24.693  1.591   17.411  1    44.458 ? 1225 LYS A HZ2    1 ? 
ATOM   3288 H HZ3    . LYS A 1 217 ? 24.687  2.849   18.494  1    48.248 ? 1225 LYS A HZ3    1 ? 
ATOM   3289 N N      . GLN A 1 218 ? 30.325  -2.434  14.957  1    17.92  ? 1226 GLN A N      1 ? 
ATOM   3290 C CA     . GLN A 1 218 ? 31.523  -3.208  15.22   1    18.099 ? 1226 GLN A CA     1 ? 
ATOM   3291 C C      . GLN A 1 218 ? 32.137  -3.775  13.945  1    18.072 ? 1226 GLN A C      1 ? 
ATOM   3292 O O      . GLN A 1 218 ? 33.364  -3.881  13.847  1    22.03  ? 1226 GLN A O      1 ? 
ATOM   3293 C CB     . GLN A 1 218 ? 31.196  -4.368  16.155  1    20.252 ? 1226 GLN A CB     1 ? 
ATOM   3294 H H      . GLN A 1 218 ? 29.392  -2.872  15.098  1    16.941 ? 1226 GLN A H      1 ? 
ATOM   3295 H HA     . GLN A 1 218 ? 32.255  -2.559  15.704  1    18.434 ? 1226 GLN A HA     1 c 
ATOM   3296 N N      . TYR A 1 219 ? 31.296  -4.157  12.987  1    17.064 ? 1227 TYR A N      1 ? 
ATOM   3297 C CA     . TYR A 1 219 ? 31.743  -4.817  11.767  1    18.363 ? 1227 TYR A CA     1 ? 
ATOM   3298 C C      . TYR A 1 219 ? 31.093  -4.16   10.547  1    17.369 ? 1227 TYR A C      1 ? 
ATOM   3299 O O      . TYR A 1 219 ? 30.42   -4.815  9.743   1    14.588 ? 1227 TYR A O      1 ? 
ATOM   3300 C CB     . TYR A 1 219 ? 31.427  -6.309  11.811  1    21.164 ? 1227 TYR A CB     1 ? 
ATOM   3301 C CG     . TYR A 1 219 ? 32.234  -7.011  12.888  1    20.897 ? 1227 TYR A CG     1 ? 
ATOM   3302 C CD1    . TYR A 1 219 ? 33.52   -7.468  12.642  1    23.565 ? 1227 TYR A CD1    1 ? 
ATOM   3303 C CD2    . TYR A 1 219 ? 31.703  -7.216  14.154  1    24.224 ? 1227 TYR A CD2    1 ? 
ATOM   3304 C CE1    . TYR A 1 219 ? 34.269  -8.098  13.625  1    24.957 ? 1227 TYR A CE1    1 ? 
ATOM   3305 C CE2    . TYR A 1 219 ? 32.436  -7.835  15.156  1    23.883 ? 1227 TYR A CE2    1 ? 
ATOM   3306 C CZ     . TYR A 1 219 ? 33.718  -8.284  14.888  1    27.226 ? 1227 TYR A CZ     1 ? 
ATOM   3307 O OH     . TYR A 1 219 ? 34.449  -8.903  15.873  1    30.662 ? 1227 TYR A OH     1 ? 
ATOM   3308 H H      . TYR A 1 219 ? 30.298  -3.99   13.119  1    17.54  ? 1227 TYR A H      1 ? 
ATOM   3309 H HA     . TYR A 1 219 ? 32.824  -4.697  11.689  1    18.385 ? 1227 TYR A HA     1 c 
ATOM   3310 H HB2    . TYR A 1 219 ? 30.362  -6.442  12.011  1    20.446 ? 1227 TYR A HB2    1 c 
ATOM   3311 H HB3    . TYR A 1 219 ? 31.661  -6.75   10.84   1    20.38  ? 1227 TYR A HB3    1 c 
ATOM   3312 H HD1    . TYR A 1 219 ? 33.956  -7.32   11.66   1    23.28  ? 1227 TYR A HD1    1 c 
ATOM   3313 H HD2    . TYR A 1 219 ? 30.702  -6.862  14.374  1    23.412 ? 1227 TYR A HD2    1 c 
ATOM   3314 H HE1    . TYR A 1 219 ? 35.276  -8.444  13.412  1    25.098 ? 1227 TYR A HE1    1 c 
ATOM   3315 H HE2    . TYR A 1 219 ? 32.002  -7.982  16.14   1    24.65  ? 1227 TYR A HE2    1 c 
ATOM   3316 H HH     . TYR A 1 219 ? 33.989  -8.886  16.727  1    28.844 ? 1227 TYR A HH     1 ? 
ATOM   3317 N N      . PRO A 1 220 ? 31.302  -2.847  10.365  1    18.73  ? 1228 PRO A N      1 ? 
ATOM   3318 C CA     . PRO A 1 220 ? 30.614  -2.129  9.291   1    17.049 ? 1228 PRO A CA     1 ? 
ATOM   3319 C C      . PRO A 1 220 ? 30.951  -2.62   7.891   1    17.294 ? 1228 PRO A C      1 ? 
ATOM   3320 O O      . PRO A 1 220 ? 30.18   -2.381  6.957   1    17.242 ? 1228 PRO A O      1 ? 
ATOM   3321 C CB     . PRO A 1 220 ? 31.073  -0.68   9.482   1    18.151 ? 1228 PRO A CB     1 ? 
ATOM   3322 C CG     . PRO A 1 220 ? 32.409  -0.818  10.16   1    18.055 ? 1228 PRO A CG     1 ? 
ATOM   3323 C CD     . PRO A 1 220 ? 32.219  -1.968  11.109  1    18.719 ? 1228 PRO A CD     1 ? 
ATOM   3324 H HA     . PRO A 1 220 ? 29.537  -2.196  9.447   1    17.602 ? 1228 PRO A HA     1 c 
ATOM   3325 H HB2    . PRO A 1 220 ? 31.172  -0.171  8.521   1    17.882 ? 1228 PRO A HB2    1 c 
ATOM   3326 H HB3    . PRO A 1 220 ? 30.371  -0.127  10.11   1    17.872 ? 1228 PRO A HB3    1 c 
ATOM   3327 H HG2    . PRO A 1 220 ? 33.196  -1.04   9.436   1    18.219 ? 1228 PRO A HG2    1 c 
ATOM   3328 H HG3    . PRO A 1 220 ? 32.671  0.091   10.701  1    18.219 ? 1228 PRO A HG3    1 c 
ATOM   3329 H HD2    . PRO A 1 220 ? 33.163  -2.476  11.316  1    18.575 ? 1228 PRO A HD2    1 c 
ATOM   3330 H HD3    . PRO A 1 220 ? 31.769  -1.641  12.049  1    18.576 ? 1228 PRO A HD3    1 c 
ATOM   3331 N N      . ASP A 1 221 ? 32.119  -3.263  7.714   1    17.104 ? 1229 ASP A N      1 ? 
ATOM   3332 C CA     . ASP A 1 221 ? 32.503  -3.784  6.417   1    16.774 ? 1229 ASP A CA     1 ? 
ATOM   3333 C C      . ASP A 1 221 ? 32.145  -5.256  6.213   1    17.342 ? 1229 ASP A C      1 ? 
ATOM   3334 O O      . ASP A 1 221 ? 32.427  -5.803  5.145   1    17.954 ? 1229 ASP A O      1 ? 
ATOM   3335 C CB     . ASP A 1 221 ? 33.983  -3.552  6.174   1    19.141 ? 1229 ASP A CB     1 ? 
ATOM   3336 C CG     . ASP A 1 221 ? 34.274  -3.189  4.721   1    21.563 ? 1229 ASP A CG     1 ? 
ATOM   3337 O OD1    . ASP A 1 221 ? 33.469  -2.437  4.083   1    19.484 ? 1229 ASP A OD1    1 ? 
ATOM   3338 O OD2    . ASP A 1 221 ? 35.326  -3.63   4.231   1    22.354 ? 1229 ASP A OD2    1 ? 
ATOM   3339 H H      . ASP A 1 221 ? 32.78   -3.394  8.505   1    17.327 ? 1229 ASP A H      1 ? 
ATOM   3340 H HA     . ASP A 1 221 ? 31.97   -3.208  5.66    1    17.381 ? 1229 ASP A HA     1 c 
ATOM   3341 H HB2    . ASP A 1 221 ? 34.333  -2.74   6.815   1    19.086 ? 1229 ASP A HB2    1 c 
ATOM   3342 H HB3    . ASP A 1 221 ? 34.54   -4.456  6.427   1    19.077 ? 1229 ASP A HB3    1 c 
ATOM   3343 N N      . ASN A 1 222 ? 31.519  -5.897  7.202   1    15.53  ? 1230 ASN A N      1 ? 
ATOM   3344 C CA     . ASN A 1 222 ? 31.183  -7.309  7.11    1    15.609 ? 1230 ASN A CA     1 ? 
ATOM   3345 C C      . ASN A 1 222 ? 29.726  -7.617  7.422   1    15.69  ? 1230 ASN A C      1 ? 
ATOM   3346 O O      . ASN A 1 222 ? 29.321  -8.773  7.278   1    16.233 ? 1230 ASN A O      1 ? 
ATOM   3347 C CB     . ASN A 1 222 ? 32.08   -8.149  8.03    1    15.911 ? 1230 ASN A CB     1 ? 
ATOM   3348 C CG     . ASN A 1 222 ? 33.547  -7.972  7.735   1    17.175 ? 1230 ASN A CG     1 ? 
ATOM   3349 O OD1    . ASN A 1 222 ? 34.199  -7.102  8.323   1    16.56  ? 1230 ASN A OD1    1 ? 
ATOM   3350 N ND2    . ASN A 1 222 ? 34.086  -8.772  6.823   1    17.267 ? 1230 ASN A ND2    1 ? 
ATOM   3351 H H      . ASN A 1 222 ? 31.213  -5.364  8.034   1    14.747 ? 1230 ASN A H      1 ? 
ATOM   3352 H HA     . ASN A 1 222 ? 31.379  -7.635  6.087   1    15.686 ? 1230 ASN A HA     1 c 
ATOM   3353 H HB2    . ASN A 1 222 ? 31.889  -7.868  9.068   1    16.148 ? 1230 ASN A HB2    1 c 
ATOM   3354 H HB3    . ASN A 1 222 ? 31.819  -9.204  7.915   1    16.121 ? 1230 ASN A HB3    1 c 
ATOM   3355 H HD21   . ASN A 1 222 ? 35.063  -8.762  6.676   1    17.953 ? 1230 ASN A HD21   1 ? 
ATOM   3356 H HD22   . ASN A 1 222 ? 33.498  -9.338  6.228   1    17.943 ? 1230 ASN A HD22   1 ? 
ATOM   3357 N N      . PHE A 1 223 ? 28.93   -6.636  7.856   1    15.743 ? 1231 PHE A N      1 ? 
ATOM   3358 C CA     . PHE A 1 223 ? 27.555  -6.883  8.259   1    14.663 ? 1231 PHE A CA     1 ? 
ATOM   3359 C C      . PHE A 1 223 ? 26.658  -5.791  7.71    1    14.732 ? 1231 PHE A C      1 ? 
ATOM   3360 O O      . PHE A 1 223 ? 27      -4.61   7.797   1    15.062 ? 1231 PHE A O      1 ? 
ATOM   3361 C CB     . PHE A 1 223 ? 27.418  -6.92   9.787   1    14.828 ? 1231 PHE A CB     1 ? 
ATOM   3362 C CG     . PHE A 1 223 ? 26.015  -7.177  10.259  1    14.28  ? 1231 PHE A CG     1 ? 
ATOM   3363 C CD1    . PHE A 1 223 ? 25.399  -8.387  9.981   1    15.399 ? 1231 PHE A CD1    1 ? 
ATOM   3364 C CD2    . PHE A 1 223 ? 25.309  -6.215  10.95   1    14.495 ? 1231 PHE A CD2    1 ? 
ATOM   3365 C CE1    . PHE A 1 223 ? 24.106  -8.647  10.404  1    14.937 ? 1231 PHE A CE1    1 ? 
ATOM   3366 C CE2    . PHE A 1 223 ? 24.017  -6.463  11.401  1    15.053 ? 1231 PHE A CE2    1 ? 
ATOM   3367 C CZ     . PHE A 1 223 ? 23.406  -7.686  11.12   1    14.569 ? 1231 PHE A CZ     1 ? 
ATOM   3368 H H      . PHE A 1 223 ? 29.297  -5.671  7.92    1    15.479 ? 1231 PHE A H      1 ? 
ATOM   3369 H HA     . PHE A 1 223 ? 27.236  -7.842  7.855   1    14.895 ? 1231 PHE A HA     1 c 
ATOM   3370 H HB2    . PHE A 1 223 ? 28.072  -7.702  10.177  1    14.669 ? 1231 PHE A HB2    1 c 
ATOM   3371 H HB3    . PHE A 1 223 ? 27.758  -5.963  10.19   1    14.669 ? 1231 PHE A HB3    1 c 
ATOM   3372 H HD1    . PHE A 1 223 ? 25.944  -9.146  9.429   1    15.038 ? 1231 PHE A HD1    1 c 
ATOM   3373 H HD2    . PHE A 1 223 ? 25.784  -5.266  11.178  1    14.577 ? 1231 PHE A HD2    1 c 
ATOM   3374 H HE1    . PHE A 1 223 ? 23.645  -9.605  10.184  1    14.949 ? 1231 PHE A HE1    1 c 
ATOM   3375 H HE2    . PHE A 1 223 ? 23.476  -5.698  11.946  1    14.843 ? 1231 PHE A HE2    1 c 
ATOM   3376 H HZ     . PHE A 1 223 ? 22.392  -7.881  11.452  1    14.755 ? 1231 PHE A HZ     1 c 
ATOM   3377 N N      . ARG A 1 224 ? 25.514  -6.192  7.16    1    15.82  ? 1232 ARG A N      1 ? 
ATOM   3378 C CA     . ARG A 1 224 ? 24.457  -5.278  6.733   1    15.384 ? 1232 ARG A CA     1 ? 
ATOM   3379 C C      . ARG A 1 224 ? 23.141  -5.761  7.337   1    16.542 ? 1232 ARG A C      1 ? 
ATOM   3380 O O      . ARG A 1 224 ? 22.986  -6.954  7.627   1    16.188 ? 1232 ARG A O      1 ? 
ATOM   3381 C CB     . ARG A 1 224 ? 24.361  -5.195  5.206   1    15.62  ? 1232 ARG A CB     1 ? 
ATOM   3382 C CG     . ARG A 1 224 ? 25.619  -4.592  4.589   1    16.309 ? 1232 ARG A CG     1 ? 
ATOM   3383 C CD     . ARG A 1 224 ? 25.613  -4.655  3.069   1    15.483 ? 1232 ARG A CD     1 ? 
ATOM   3384 N NE     . ARG A 1 224 ? 24.629  -3.74   2.483   1    16.174 ? 1232 ARG A NE     1 ? 
ATOM   3385 C CZ     . ARG A 1 224 ? 24.647  -3.372  1.212   1    17.672 ? 1232 ARG A CZ     1 ? 
ATOM   3386 N NH1    . ARG A 1 224 ? 25.582  -3.779  0.407   1    17.935 ? 1232 ARG A NH1    1 ? 
ATOM   3387 N NH2    . ARG A 1 224 ? 23.712  -2.578  0.735   1    19.542 ? 1232 ARG A NH2    1 ? 
ATOM   3388 H H      . ARG A 1 224 ? 25.327  -7.201  7.038   1    13.761 ? 1232 ARG A H      1 ? 
ATOM   3389 H HA     . ARG A 1 224 ? 24.678  -4.285  7.129   1    15.704 ? 1232 ARG A HA     1 c 
ATOM   3390 H HB2    . ARG A 1 224 ? 24.21   -6.198  4.8     1    15.709 ? 1232 ARG A HB2    1 c 
ATOM   3391 H HB3    . ARG A 1 224 ? 23.498  -4.585  4.931   1    15.714 ? 1232 ARG A HB3    1 c 
ATOM   3392 H HG2    . ARG A 1 224 ? 25.706  -3.549  4.9     1    15.972 ? 1232 ARG A HG2    1 c 
ATOM   3393 H HG3    . ARG A 1 224 ? 26.494  -5.127  4.963   1    15.967 ? 1232 ARG A HG3    1 c 
ATOM   3394 H HD2    . ARG A 1 224 ? 26.607  -4.394  2.704   1    15.846 ? 1232 ARG A HD2    1 c 
ATOM   3395 H HD3    . ARG A 1 224 ? 25.392  -5.676  2.749   1    15.819 ? 1232 ARG A HD3    1 c 
ATOM   3396 H HE     . ARG A 1 224 ? 23.842  -3.385  3.014   1    16.735 ? 1232 ARG A HE     1 ? 
ATOM   3397 H HH11   . ARG A 1 224 ? 26.443  -4.221  0.754   1    18.089 ? 1232 ARG A HH11   1 ? 
ATOM   3398 H HH12   . ARG A 1 224 ? 25.401  -3.528  -0.549  1    18.014 ? 1232 ARG A HH12   1 ? 
ATOM   3399 H HH21   . ARG A 1 224 ? 23.089  -2.037  1.319   1    20.957 ? 1232 ARG A HH21   1 ? 
ATOM   3400 H HH22   . ARG A 1 224 ? 23.697  -2.444  -0.254  1    21.804 ? 1232 ARG A HH22   1 ? 
ATOM   3401 N N      . TYR A 1 225 ? 22.198  -4.838  7.536   1    14.919 ? 1233 TYR A N      1 ? 
ATOM   3402 C CA     . TYR A 1 225 ? 20.995  -5.116  8.307   1    15.63  ? 1233 TYR A CA     1 ? 
ATOM   3403 C C      . TYR A 1 225 ? 19.869  -4.228  7.8     1    17.238 ? 1233 TYR A C      1 ? 
ATOM   3404 O O      . TYR A 1 225 ? 19.991  -3.002  7.839   1    15.967 ? 1233 TYR A O      1 ? 
ATOM   3405 C CB     . TYR A 1 225 ? 21.275  -4.806  9.779   1    14.916 ? 1233 TYR A CB     1 ? 
ATOM   3406 C CG     . TYR A 1 225 ? 20.153  -5.008  10.78   1    14.27  ? 1233 TYR A CG     1 ? 
ATOM   3407 C CD1    . TYR A 1 225 ? 19.241  -6.048  10.672  1    14.865 ? 1233 TYR A CD1    1 ? 
ATOM   3408 C CD2    . TYR A 1 225 ? 20.076  -4.188  11.901  1    15.873 ? 1233 TYR A CD2    1 ? 
ATOM   3409 C CE1    . TYR A 1 225 ? 18.238  -6.233  11.626  1    15.313 ? 1233 TYR A CE1    1 ? 
ATOM   3410 C CE2    . TYR A 1 225 ? 19.097  -4.367  12.866  1    15.805 ? 1233 TYR A CE2    1 ? 
ATOM   3411 C CZ     . TYR A 1 225 ? 18.178  -5.397  12.733  1    15.45  ? 1233 TYR A CZ     1 ? 
ATOM   3412 O OH     . TYR A 1 225 ? 17.212  -5.592  13.693  1    15.435 ? 1233 TYR A OH     1 ? 
ATOM   3413 H H      . TYR A 1 225 ? 22.387  -3.861  7.3     1    16.256 ? 1233 TYR A H      1 ? 
ATOM   3414 H HA     . TYR A 1 225 ? 20.721  -6.164  8.197   1    15.631 ? 1233 TYR A HA     1 c 
ATOM   3415 H HB2    . TYR A 1 225 ? 22.121  -5.418  10.091  1    14.924 ? 1233 TYR A HB2    1 c 
ATOM   3416 H HB3    . TYR A 1 225 ? 21.603  -3.767  9.844   1    14.923 ? 1233 TYR A HB3    1 c 
ATOM   3417 H HD1    . TYR A 1 225 ? 19.286  -6.71   9.813   1    14.85  ? 1233 TYR A HD1    1 c 
ATOM   3418 H HD2    . TYR A 1 225 ? 20.796  -3.385  12.02   1    15.486 ? 1233 TYR A HD2    1 c 
ATOM   3419 H HE1    . TYR A 1 225 ? 17.527  -7.046  11.519  1    15.244 ? 1233 TYR A HE1    1 c 
ATOM   3420 H HE2    . TYR A 1 225 ? 19.053  -3.707  13.726  1    15.724 ? 1233 TYR A HE2    1 c 
ATOM   3421 H HH     . TYR A 1 225 ? 17.122  -4.885  14.38   1    15.586 ? 1233 TYR A HH     1 ? 
ATOM   3422 N N      . ASP A 1 226 ? 18.782  -4.84   7.329   1    16.183 ? 1234 ASP A N      1 ? 
ATOM   3423 C CA     . ASP A 1 226 ? 17.635  -4.116  6.801   1    18.615 ? 1234 ASP A CA     1 ? 
ATOM   3424 C C      . ASP A 1 226 ? 16.347  -4.699  7.377   1    19.785 ? 1234 ASP A C      1 ? 
ATOM   3425 O O      . ASP A 1 226 ? 16.197  -5.918  7.463   1    17.375 ? 1234 ASP A O      1 ? 
ATOM   3426 C CB     . ASP A 1 226 ? 17.63   -4.166  5.287   1    18.487 ? 1234 ASP A CB     1 ? 
ATOM   3427 C CG     . ASP A 1 226 ? 18.725  -3.305  4.682   1    18.52  ? 1234 ASP A CG     1 ? 
ATOM   3428 O OD1    . ASP A 1 226 ? 18.524  -2.071  4.596   1    20.129 ? 1234 ASP A OD1    1 ? 
ATOM   3429 O OD2    . ASP A 1 226 ? 19.79   -3.837  4.332   1    16.932 ? 1234 ASP A OD2    1 ? 
ATOM   3430 H H      . ASP A 1 226 ? 18.761  -5.877  7.324   1    16.317 ? 1234 ASP A H      1 ? 
ATOM   3431 H HA     . ASP A 1 226 ? 17.712  -3.071  7.109   1    18.288 ? 1234 ASP A HA     1 c 
ATOM   3432 H HB2    . ASP A 1 226 ? 17.774  -5.197  4.959   1    18.529 ? 1234 ASP A HB2    1 c 
ATOM   3433 H HB3    . ASP A 1 226 ? 16.664  -3.818  4.916   1    18.554 ? 1234 ASP A HB3    1 c 
ATOM   3434 N N      . LYS A 1 227 ? 15.422  -3.814  7.752   1    16.873 ? 1235 LYS A N      1 ? 
ATOM   3435 C CA     . LYS A 1 227 ? 14.188  -4.194  8.414   1    17.251 ? 1235 LYS A CA     1 ? 
ATOM   3436 C C      . LYS A 1 227 ? 12.964  -3.768  7.61    1    16.828 ? 1235 LYS A C      1 ? 
ATOM   3437 O O      . LYS A 1 227 ? 12.968  -2.699  6.982   1    18.254 ? 1235 LYS A O      1 ? 
ATOM   3438 C CB     . LYS A 1 227 ? 14.116  -3.548  9.806   1    16.646 ? 1235 LYS A CB     1 ? 
ATOM   3439 C CG     . LYS A 1 227 ? 15.043  -4.184  10.801  1    16.901 ? 1235 LYS A CG     1 ? 
ATOM   3440 C CD     . LYS A 1 227 ? 15.263  -3.334  12.029  1    16.772 ? 1235 LYS A CD     1 ? 
ATOM   3441 C CE     . LYS A 1 227 ? 16.358  -2.299  11.807  1    18.009 ? 1235 LYS A CE     1 ? 
ATOM   3442 N NZ     . LYS A 1 227 ? 16.597  -1.476  13.023  1    18.864 ? 1235 LYS A NZ     1 ? 
ATOM   3443 H H      . LYS A 1 227 ? 15.603  -2.812  7.602   1    18.089 ? 1235 LYS A H      1 ? 
ATOM   3444 H HA     . LYS A 1 227 ? 14.176  -5.278  8.525   1    17.012 ? 1235 LYS A HA     1 c 
ATOM   3445 H HB2    . LYS A 1 227 ? 14.365  -2.488  9.722   1    16.831 ? 1235 LYS A HB2    1 c 
ATOM   3446 H HB3    . LYS A 1 227 ? 13.093  -3.624  10.182  1    16.831 ? 1235 LYS A HB3    1 c 
ATOM   3447 H HG2    . LYS A 1 227 ? 14.627  -5.147  11.103  1    16.816 ? 1235 LYS A HG2    1 c 
ATOM   3448 H HG3    . LYS A 1 227 ? 16.004  -4.368  10.316  1    16.816 ? 1235 LYS A HG3    1 c 
ATOM   3449 H HD2    . LYS A 1 227 ? 14.333  -2.821  12.283  1    17.06  ? 1235 LYS A HD2    1 c 
ATOM   3450 H HD3    . LYS A 1 227 ? 15.539  -3.975  12.868  1    17.052 ? 1235 LYS A HD3    1 c 
ATOM   3451 H HE2    . LYS A 1 227 ? 17.287  -2.801  11.527  1    17.944 ? 1235 LYS A HE2    1 c 
ATOM   3452 H HE3    . LYS A 1 227 ? 16.061  -1.647  10.985  1    18.098 ? 1235 LYS A HE3    1 c 
ATOM   3453 H HZ1    . LYS A 1 227 ? 15.881  -0.775  13.158  1    18.036 ? 1235 LYS A HZ1    1 ? 
ATOM   3454 H HZ2    . LYS A 1 227 ? 16.425  -2.01   13.864  1    17.085 ? 1235 LYS A HZ2    1 ? 
ATOM   3455 H HZ3    . LYS A 1 227 ? 17.531  -1.026  12.992  1    17.552 ? 1235 LYS A HZ3    1 ? 
ATOM   3456 N N      . ALA A 1 228 ? 11.919  -4.58   7.683   1    17.49  ? 1236 ALA A N      1 ? 
ATOM   3457 C CA     . ALA A 1 228 ? 10.626  -4.258  7.09    1    19.507 ? 1236 ALA A CA     1 ? 
ATOM   3458 C C      . ALA A 1 228 ? 9.585   -4.326  8.197   1    20.498 ? 1236 ALA A C      1 ? 
ATOM   3459 O O      . ALA A 1 228 ? 9.413   -5.374  8.819   1    18.271 ? 1236 ALA A O      1 ? 
ATOM   3460 C CB     . ALA A 1 228 ? 10.24   -5.202  5.94    1    19.78  ? 1236 ALA A CB     1 ? 
ATOM   3461 H H      . ALA A 1 228 ? 12.01   -5.464  8.211   1    17.282 ? 1236 ALA A H      1 ? 
ATOM   3462 H HA     . ALA A 1 228 ? 10.662  -3.233  6.716   1    19.316 ? 1236 ALA A HA     1 c 
ATOM   3463 H HB1    . ALA A 1 228 ? 9.269   -4.912  5.536   1    19.693 ? 1236 ALA A HB1    1 c 
ATOM   3464 H HB2    . ALA A 1 228 ? 10.991  -5.144  5.149   1    19.689 ? 1236 ALA A HB2    1 c 
ATOM   3465 H HB3    . ALA A 1 228 ? 10.184  -6.228  6.31    1    19.64  ? 1236 ALA A HB3    1 c 
ATOM   3466 N N      . LEU A 1 229 ? 8.896   -3.199  8.437   1    21.006 ? 1237 LEU A N      1 ? 
ATOM   3467 C CA     . LEU A 1 229 ? 7.871   -3.113  9.469   1    23.102 ? 1237 LEU A CA     1 ? 
ATOM   3468 C C      . LEU A 1 229 ? 6.565   -2.907  8.73    1    21.786 ? 1237 LEU A C      1 ? 
ATOM   3469 O O      . LEU A 1 229 ? 6.274   -1.787  8.358   1    26.357 ? 1237 LEU A O      1 ? 
ATOM   3470 C CB     . LEU A 1 229 ? 8.178   -1.934  10.402  1    20.853 ? 1237 LEU A CB     1 ? 
ATOM   3471 C CG     . LEU A 1 229 ? 9.603   -1.836  10.952  1    21.921 ? 1237 LEU A CG     1 ? 
ATOM   3472 C CD1    . LEU A 1 229 ? 9.747   -0.605  11.821  1    24.788 ? 1237 LEU A CD1    1 ? 
ATOM   3473 C CD2    . LEU A 1 229 ? 9.982   -3.102  11.71   1    24.507 ? 1237 LEU A CD2    1 ? 
ATOM   3474 H H      . LEU A 1 229 ? 9.144   -2.334  7.929   1    20.753 ? 1237 LEU A H      1 ? 
ATOM   3475 H HA     . LEU A 1 229 ? 7.842   -4.041  10.035  1    22.03  ? 1237 LEU A HA     1 c 
ATOM   3476 H HB2    . LEU A 1 229 ? 7.958   -1.009  9.865   1    21.59  ? 1237 LEU A HB2    1 c 
ATOM   3477 H HB3    . LEU A 1 229 ? 7.489   -1.983  11.247  1    21.578 ? 1237 LEU A HB3    1 c 
ATOM   3478 H HG     . LEU A 1 229 ? 10.287  -1.733  10.106  1    22.658 ? 1237 LEU A HG     1 c 
ATOM   3479 H HD11   . LEU A 1 229 ? 9.044   -0.663  12.655  1    23.929 ? 1237 LEU A HD11   1 c 
ATOM   3480 H HD12   . LEU A 1 229 ? 10.766  -0.549  12.209  1    23.929 ? 1237 LEU A HD12   1 c 
ATOM   3481 H HD13   . LEU A 1 229 ? 9.534   0.287   11.229  1    23.858 ? 1237 LEU A HD13   1 c 
ATOM   3482 H HD21   . LEU A 1 229 ? 9.954   -3.957  11.031  1    23.734 ? 1237 LEU A HD21   1 c 
ATOM   3483 H HD22   . LEU A 1 229 ? 10.989  -2.996  12.117  1    23.736 ? 1237 LEU A HD22   1 c 
ATOM   3484 H HD23   . LEU A 1 229 ? 9.276   -3.264  12.526  1    23.665 ? 1237 LEU A HD23   1 c 
ATOM   3485 N N      A SER A 1 230 ? 5.772   -3.983  8.633   0.63 24.476 ? 1238 SER A N      1 ? 
ATOM   3486 N N      B SER A 1 230 ? 5.76    -3.935  8.512   0.37 22.8   ? 1238 SER A N      1 ? 
ATOM   3487 C CA     A SER A 1 230 ? 4.689   -4.137  7.665   0.63 23.151 ? 1238 SER A CA     1 ? 
ATOM   3488 C CA     B SER A 1 230 ? 4.622   -3.774  7.62    0.37 21.156 ? 1238 SER A CA     1 ? 
ATOM   3489 C C      A SER A 1 230 ? 3.437   -3.326  8.02    0.63 24.056 ? 1238 SER A C      1 ? 
ATOM   3490 C C      B SER A 1 230 ? 3.784   -2.534  7.977   0.37 20.309 ? 1238 SER A C      1 ? 
ATOM   3491 O O      A SER A 1 230 ? 2.76    -2.824  7.132   0.63 25.042 ? 1238 SER A O      1 ? 
ATOM   3492 O O      B SER A 1 230 ? 3.247   -1.879  7.084   0.37 20.807 ? 1238 SER A O      1 ? 
ATOM   3493 C CB     A SER A 1 230 ? 4.317   -5.605  7.504   0.63 21.374 ? 1238 SER A CB     1 ? 
ATOM   3494 C CB     B SER A 1 230 ? 3.781   -5.027  7.622   0.37 20.695 ? 1238 SER A CB     1 ? 
ATOM   3495 O OG     A SER A 1 230 ? 3.694   -6.128  8.666   0.63 22.605 ? 1238 SER A OG     1 ? 
ATOM   3496 O OG     B SER A 1 230 ? 2.991   -5.102  8.798   0.37 21.327 ? 1238 SER A OG     1 ? 
ATOM   3497 H H      A SER A 1 230 ? 5.942   -4.767  9.292   0.63 22.283 ? 1238 SER A H      1 ? 
ATOM   3498 H H      B SER A 1 230 ? 5.921   -4.845  8.982   0.37 21.99  ? 1238 SER A H      1 ? 
ATOM   3499 H HA     A SER A 1 230 ? 5.054   -3.773  6.703   0.63 23.212 ? 1238 SER A HA     1 c 
ATOM   3500 H HA     B SER A 1 230 ? 5.012   -3.632  6.61    0.37 21.219 ? 1238 SER A HA     1 c 
ATOM   3501 H HB2    A SER A 1 230 ? 3.638   -5.71   6.655   0.63 22.063 ? 1238 SER A HB2    1 c 
ATOM   3502 H HB2    B SER A 1 230 ? 3.13    -5.027  6.745   0.37 20.939 ? 1238 SER A HB2    1 c 
ATOM   3503 H HB3    A SER A 1 230 ? 5.21    -6.184  7.291   0.63 22.206 ? 1238 SER A HB3    1 c 
ATOM   3504 H HB3    B SER A 1 230 ? 4.433   -5.901  7.565   0.37 20.939 ? 1238 SER A HB3    1 c 
ATOM   3505 H HG     A SER A 1 230 ? 3.573   -7.08   8.556   0.63 22.164 ? 1238 SER A HG     1 ? 
ATOM   3506 H HG     B SER A 1 230 ? 2.427   -5.881  8.684   0.37 20.195 ? 1238 SER A HG     1 ? 
ATOM   3507 N N      A ARG A 1 231 ? 3.087   -3.239  9.304   0.63 22.408 ? 1239 ARG A N      1 ? 
ATOM   3508 N N      B ARG A 1 231 ? 3.699   -2.182  9.27    0.37 18.74  ? 1239 ARG A N      1 ? 
ATOM   3509 C CA     A ARG A 1 231 ? 1.904   -2.497  9.697   0.63 23.853 ? 1239 ARG A CA     1 ? 
ATOM   3510 C CA     B ARG A 1 231 ? 2.69    -1.25   9.762   0.37 18.817 ? 1239 ARG A CA     1 ? 
ATOM   3511 C C      A ARG A 1 231 ? 2.25    -1.01   9.814   0.63 23.001 ? 1239 ARG A C      1 ? 
ATOM   3512 C C      B ARG A 1 231 ? 3.225   0.18    9.896   0.37 19.557 ? 1239 ARG A C      1 ? 
ATOM   3513 O O      A ARG A 1 231 ? 1.352   -0.178  9.937   0.63 25.352 ? 1239 ARG A O      1 ? 
ATOM   3514 O O      B ARG A 1 231 ? 2.442   1.109   10.083  0.37 18.918 ? 1239 ARG A O      1 ? 
ATOM   3515 C CB     A ARG A 1 231 ? 1.307   -3.095  10.981  0.63 23.587 ? 1239 ARG A CB     1 ? 
ATOM   3516 C CB     B ARG A 1 231 ? 2.138   -1.709  11.122  0.37 19.323 ? 1239 ARG A CB     1 ? 
ATOM   3517 C CG     A ARG A 1 231 ? 0.8     -4.526  10.838  0.63 24.381 ? 1239 ARG A CG     1 ? 
ATOM   3518 C CG     B ARG A 1 231 ? 1.407   -3.046  11.08   0.37 20.54  ? 1239 ARG A CG     1 ? 
ATOM   3519 C CD     A ARG A 1 231 ? 0.095   -5.009  12.12   0.63 24.898 ? 1239 ARG A CD     1 ? 
ATOM   3520 C CD     B ARG A 1 231 ? 0.76    -3.408  12.408  0.37 21.825 ? 1239 ARG A CD     1 ? 
ATOM   3521 N NE     A ARG A 1 231 ? -0.312  -6.422  12.094  0.63 27.02  ? 1239 ARG A NE     1 ? 
ATOM   3522 N NE     B ARG A 1 231 ? 0.163   -4.748  12.442  0.37 23.052 ? 1239 ARG A NE     1 ? 
ATOM   3523 C CZ     A ARG A 1 231 ? -1.12   -7.02   12.97   0.63 28.694 ? 1239 ARG A CZ     1 ? 
ATOM   3524 C CZ     B ARG A 1 231 ? -0.649  -5.203  13.391  0.37 25.7   ? 1239 ARG A CZ     1 ? 
ATOM   3525 N NH1    A ARG A 1 231 ? -1.677  -6.354  13.967  0.63 29.105 ? 1239 ARG A NH1    1 ? 
ATOM   3526 N NH1    B ARG A 1 231 ? -1.124  -4.399  14.332  0.37 27.158 ? 1239 ARG A NH1    1 ? 
ATOM   3527 N NH2    A ARG A 1 231 ? -1.359  -8.312  12.846  0.63 31.588 ? 1239 ARG A NH2    1 ? 
ATOM   3528 N NH2    B ARG A 1 231 ? -1.053  -6.459  13.354  0.37 27.023 ? 1239 ARG A NH2    1 ? 
ATOM   3529 H H      A ARG A 1 231 ? 3.648   -3.709  10.034  0.63 21.779 ? 1239 ARG A H      1 ? 
ATOM   3530 H H      B ARG A 1 231 ? 4.375   -2.578  9.946   0.37 18.925 ? 1239 ARG A H      1 ? 
ATOM   3531 H HA     A ARG A 1 231 ? 1.16    -2.607  8.908   0.63 23.475 ? 1239 ARG A HA     1 c 
ATOM   3532 H HA     B ARG A 1 231 ? 1.865   -1.24   9.047   0.37 19.02  ? 1239 ARG A HA     1 c 
ATOM   3533 H HB2    A ARG A 1 231 ? 2.066   -3.069  11.764  0.63 23.816 ? 1239 ARG A HB2    1 c 
ATOM   3534 H HB2    B ARG A 1 231 ? 2.967   -1.784  11.829  0.37 19.494 ? 1239 ARG A HB2    1 c 
ATOM   3535 H HB3    A ARG A 1 231 ? 0.478   -2.462  11.305  0.63 23.816 ? 1239 ARG A HB3    1 c 
ATOM   3536 H HB3    B ARG A 1 231 ? 1.452   -0.946  11.495  0.37 19.476 ? 1239 ARG A HB3    1 c 
ATOM   3537 H HG2    A ARG A 1 231 ? 0.098   -4.58   10.003  0.63 24.316 ? 1239 ARG A HG2    1 c 
ATOM   3538 H HG2    B ARG A 1 231 ? 0.634   -3.006  10.31   0.37 20.543 ? 1239 ARG A HG2    1 c 
ATOM   3539 H HG3    A ARG A 1 231 ? 1.641   -5.187  10.621  0.63 24.316 ? 1239 ARG A HG3    1 c 
ATOM   3540 H HG3    B ARG A 1 231 ? 2.112   -3.832  10.803  0.37 20.558 ? 1239 ARG A HG3    1 c 
ATOM   3541 H HD2    A ARG A 1 231 ? 0.768   -4.851  12.965  0.63 25.249 ? 1239 ARG A HD2    1 c 
ATOM   3542 H HD2    B ARG A 1 231 ? 1.52    -3.343  13.189  0.37 22.002 ? 1239 ARG A HD2    1 c 
ATOM   3543 H HD3    A ARG A 1 231 ? -0.788  -4.389  12.283  0.63 25.249 ? 1239 ARG A HD3    1 c 
ATOM   3544 H HD3    B ARG A 1 231 ? -0.014  -2.67   12.629  0.37 21.999 ? 1239 ARG A HD3    1 c 
ATOM   3545 H HE     A ARG A 1 231 ? 0.056   -7.031  11.363  0.63 25.703 ? 1239 ARG A HE     1 ? 
ATOM   3546 H HE     B ARG A 1 231 ? 0.385   -5.383  11.685  0.37 23.666 ? 1239 ARG A HE     1 ? 
ATOM   3547 H HH11   A ARG A 1 231 ? -1.457  -5.379  14.148  0.63 26.037 ? 1239 ARG A HH11   1 ? 
ATOM   3548 H HH11   B ARG A 1 231 ? -0.973  -3.39   14.307  0.37 25.893 ? 1239 ARG A HH11   1 ? 
ATOM   3549 H HH12   A ARG A 1 231 ? -2.323  -6.867  14.569  0.63 29.543 ? 1239 ARG A HH12   1 ? 
ATOM   3550 H HH12   B ARG A 1 231 ? -1.667  -4.811  15.08   0.37 26.51  ? 1239 ARG A HH12   1 ? 
ATOM   3551 H HH21   A ARG A 1 231 ? -0.963  -8.805  12.049  0.63 30.584 ? 1239 ARG A HH21   1 ? 
ATOM   3552 H HH21   B ARG A 1 231 ? -0.774  -7.063  12.587  0.37 26.795 ? 1239 ARG A HH21   1 ? 
ATOM   3553 H HH22   A ARG A 1 231 ? -1.941  -8.807  13.535  0.63 30.613 ? 1239 ARG A HH22   1 ? 
ATOM   3554 H HH22   B ARG A 1 231 ? -1.649  -6.804  14.097  0.37 26.538 ? 1239 ARG A HH22   1 ? 
ATOM   3555 N N      A GLU A 1 232 ? 3.544   -0.666  9.733   0.63 25.106 ? 1240 GLU A N      1 ? 
ATOM   3556 N N      B GLU A 1 232 ? 4.545   0.374   9.783   0.37 19.178 ? 1240 GLU A N      1 ? 
ATOM   3557 C CA     A GLU A 1 232 ? 3.973   0.721   9.918   0.63 23.054 ? 1240 GLU A CA     1 ? 
ATOM   3558 C CA     B GLU A 1 232 ? 5.152   1.607   10.255  0.37 20.555 ? 1240 GLU A CA     1 ? 
ATOM   3559 C C      A GLU A 1 232 ? 4.642   1.26    8.656   0.63 24.421 ? 1240 GLU A C      1 ? 
ATOM   3560 C C      B GLU A 1 232 ? 5.765   2.437   9.118   0.37 21.297 ? 1240 GLU A C      1 ? 
ATOM   3561 O O      A GLU A 1 232 ? 4.945   2.448   8.566   0.63 22.702 ? 1240 GLU A O      1 ? 
ATOM   3562 O O      B GLU A 1 232 ? 5.794   3.663   9.215   0.37 21.427 ? 1240 GLU A O      1 ? 
ATOM   3563 C CB     A GLU A 1 232 ? 4.876   0.834   11.144  0.63 22.928 ? 1240 GLU A CB     1 ? 
ATOM   3564 C CB     B GLU A 1 232 ? 6.136   1.216   11.359  0.37 21.841 ? 1240 GLU A CB     1 ? 
ATOM   3565 C CG     A GLU A 1 232 ? 4.138   0.455   12.422  0.63 21.86  ? 1240 GLU A CG     1 ? 
ATOM   3566 C CG     B GLU A 1 232 ? 6.762   2.402   12.088  0.37 22.16  ? 1240 GLU A CG     1 ? 
ATOM   3567 C CD     A GLU A 1 232 ? 4.935   0.72    13.69   0.63 24.867 ? 1240 GLU A CD     1 ? 
ATOM   3568 C CD     B GLU A 1 232 ? 7.649   1.922   13.213  0.37 21.163 ? 1240 GLU A CD     1 ? 
ATOM   3569 O OE1    A GLU A 1 232 ? 6.166   0.973   13.579  0.63 20.67  ? 1240 GLU A OE1    1 ? 
ATOM   3570 O OE1    B GLU A 1 232 ? 8.719   2.497   13.508  0.37 20.348 ? 1240 GLU A OE1    1 ? 
ATOM   3571 O OE2    A GLU A 1 232 ? 4.295   0.68    14.781  0.63 20.506 ? 1240 GLU A OE2    1 ? 
ATOM   3572 O OE2    B GLU A 1 232 ? 7.216   0.903   13.781  0.37 21.47  ? 1240 GLU A OE2    1 ? 
ATOM   3573 H H      A GLU A 1 232 ? 4.257   -1.392  9.528   0.63 23.947 ? 1240 GLU A H      1 ? 
ATOM   3574 H H      B GLU A 1 232 ? 5.143   -0.362  9.368   0.37 19.417 ? 1240 GLU A H      1 ? 
ATOM   3575 H HA     A GLU A 1 232 ? 3.086   1.327   10.11   0.63 23.652 ? 1240 GLU A HA     1 c 
ATOM   3576 H HA     B GLU A 1 232 ? 4.365   2.207   10.717  0.37 20.637 ? 1240 GLU A HA     1 c 
ATOM   3577 H HB2    A GLU A 1 232 ? 5.739   0.179   11.011  0.63 22.719 ? 1240 GLU A HB2    1 c 
ATOM   3578 H HB2    B GLU A 1 232 ? 5.616   0.589   12.086  0.37 21.623 ? 1240 GLU A HB2    1 c 
ATOM   3579 H HB3    A GLU A 1 232 ? 5.243   1.86    11.222  0.63 22.719 ? 1240 GLU A HB3    1 c 
ATOM   3580 H HB3    B GLU A 1 232 ? 6.936   0.618   10.917  0.37 21.623 ? 1240 GLU A HB3    1 c 
ATOM   3581 H HG2    A GLU A 1 232 ? 3.204   1.019   12.475  0.63 22.723 ? 1240 GLU A HG2    1 c 
ATOM   3582 H HG2    B GLU A 1 232 ? 7.357   2.992   11.388  0.37 21.868 ? 1240 GLU A HG2    1 c 
ATOM   3583 H HG3    A GLU A 1 232 ? 3.884   -0.606  12.386  0.63 22.723 ? 1240 GLU A HG3    1 c 
ATOM   3584 H HG3    B GLU A 1 232 ? 5.974   3.037   12.499  0.37 21.868 ? 1240 GLU A HG3    1 c 
ATOM   3585 N N      A GLN A 1 233 ? 4.828   0.381   7.669   0.63 24.657 ? 1241 GLN A N      1 ? 
ATOM   3586 N N      B GLN A 1 233 ? 6.27    1.806   8.049   0.37 20.813 ? 1241 GLN A N      1 ? 
ATOM   3587 C CA     A GLN A 1 233 ? 5.469   0.764   6.418   0.63 23.768 ? 1241 GLN A CA     1 ? 
ATOM   3588 C CA     B GLN A 1 233 ? 6.851   2.57    6.951   0.37 22.672 ? 1241 GLN A CA     1 ? 
ATOM   3589 C C      A GLN A 1 233 ? 4.668   0.22    5.237   0.63 23.519 ? 1241 GLN A C      1 ? 
ATOM   3590 C C      B GLN A 1 233 ? 6.446   1.956   5.605   0.37 21.778 ? 1241 GLN A C      1 ? 
ATOM   3591 O O      A GLN A 1 233 ? 3.93    -0.752  5.394   0.63 22.475 ? 1241 GLN A O      1 ? 
ATOM   3592 O O      B GLN A 1 233 ? 6.019   0.801   5.551   0.37 20.534 ? 1241 GLN A O      1 ? 
ATOM   3593 C CB     A GLN A 1 233 ? 6.921   0.297   6.348   0.63 25.15  ? 1241 GLN A CB     1 ? 
ATOM   3594 C CB     B GLN A 1 233 ? 8.377   2.629   7.045   0.37 24.023 ? 1241 GLN A CB     1 ? 
ATOM   3595 C CG     A GLN A 1 233 ? 7.865   0.954   7.357   0.63 23.238 ? 1241 GLN A CG     1 ? 
ATOM   3596 C CG     B GLN A 1 233 ? 8.944   2.617   8.462   0.37 25.139 ? 1241 GLN A CG     1 ? 
ATOM   3597 C CD     A GLN A 1 233 ? 9.208   0.251   7.435   0.63 23.79  ? 1241 GLN A CD     1 ? 
ATOM   3598 C CD     B GLN A 1 233 ? 10.044  1.586   8.599   0.37 24.443 ? 1241 GLN A CD     1 ? 
ATOM   3599 O OE1    A GLN A 1 233 ? 9.379   -0.876  6.965   0.63 22.67  ? 1241 GLN A OE1    1 ? 
ATOM   3600 O OE1    B GLN A 1 233 ? 9.848   0.396   8.316   0.37 23.59  ? 1241 GLN A OE1    1 ? 
ATOM   3601 N NE2    A GLN A 1 233 ? 10.188  0.902   8.035   0.63 25.879 ? 1241 GLN A NE2    1 ? 
ATOM   3602 N NE2    B GLN A 1 233 ? 11.228  2.026   8.991   0.37 24.219 ? 1241 GLN A NE2    1 ? 
ATOM   3603 H H      A GLN A 1 233 ? 4.454   -0.578  7.772   0.63 22.947 ? 1241 GLN A H      1 ? 
ATOM   3604 H H      B GLN A 1 233 ? 6.241   0.774   7.987   0.37 19.968 ? 1241 GLN A H      1 ? 
ATOM   3605 H HA     A GLN A 1 233 ? 5.461   1.852   6.358   0.63 24.095 ? 1241 GLN A HA     1 c 
ATOM   3606 H HA     B GLN A 1 233 ? 6.46    3.588   7       0.37 22.379 ? 1241 GLN A HA     1 c 
ATOM   3607 H HB2    A GLN A 1 233 ? 6.943   -0.783  6.495   0.63 24.415 ? 1241 GLN A HB2    1 c 
ATOM   3608 H HB2    B GLN A 1 233 ? 8.786   1.776   6.499   0.37 23.957 ? 1241 GLN A HB2    1 c 
ATOM   3609 H HB3    A GLN A 1 233 ? 7.296   0.494   5.342   0.63 24.391 ? 1241 GLN A HB3    1 c 
ATOM   3610 H HB3    B GLN A 1 233 ? 8.718   3.534   6.539   0.37 23.957 ? 1241 GLN A HB3    1 c 
ATOM   3611 H HG2    A GLN A 1 233 ? 8.026   1.997   7.076   0.63 23.762 ? 1241 GLN A HG2    1 c 
ATOM   3612 H HG2    B GLN A 1 233 ? 9.343   3.605   8.705   0.37 24.74  ? 1241 GLN A HG2    1 c 
ATOM   3613 H HG3    A GLN A 1 233 ? 7.402   0.942   8.346   0.63 23.764 ? 1241 GLN A HG3    1 c 
ATOM   3614 H HG3    B GLN A 1 233 ? 8.147   2.391   9.174   0.37 24.74  ? 1241 GLN A HG3    1 c 
ATOM   3615 H HE21   A GLN A 1 233 ? 9.992   1.78    8.492   0.63 24.912 ? 1241 GLN A HE21   1 ? 
ATOM   3616 H HE21   B GLN A 1 233 ? 11.36   3.01    9.226   0.37 25.254 ? 1241 GLN A HE21   1 ? 
ATOM   3617 H HE22   A GLN A 1 233 ? 11.118  0.502   8.028   0.63 25.465 ? 1241 GLN A HE22   1 ? 
ATOM   3618 H HE22   B GLN A 1 233 ? 11.982  1.355   9.066   0.37 22.91  ? 1241 GLN A HE22   1 ? 
ATOM   3619 N N      A LYS A 1 234 ? 4.846   0.867   4.072   0.5  23.239 ? 1242 LYS A N      1 ? 
ATOM   3620 N N      B LYS A 1 234 ? 6.584   2.75    4.529   0.5  20.502 ? 1242 LYS A N      1 ? 
ATOM   3621 C CA     A LYS A 1 234 ? 4.209   0.539   2.804   0.5  25.499 ? 1242 LYS A CA     1 ? 
ATOM   3622 C CA     B LYS A 1 234 ? 6.114   2.415   3.195   0.5  23.026 ? 1242 LYS A CA     1 ? 
ATOM   3623 C C      A LYS A 1 234 ? 5.28    0.31    1.733   0.5  24.882 ? 1242 LYS A C      1 ? 
ATOM   3624 C C      B LYS A 1 234 ? 7.299   2.232   2.244   0.5  21.133 ? 1242 LYS A C      1 ? 
ATOM   3625 O O      A LYS A 1 234 ? 6.299   0.998   1.734   0.5  22.985 ? 1242 LYS A O      1 ? 
ATOM   3626 O O      B LYS A 1 234 ? 8.368   2.803   2.44    0.5  21.573 ? 1242 LYS A O      1 ? 
ATOM   3627 C CB     A LYS A 1 234 ? 3.48    1.807   2.341   0.5  29.522 ? 1242 LYS A CB     1 ? 
ATOM   3628 C CB     B LYS A 1 234 ? 5.246   3.602   2.763   0.5  25.705 ? 1242 LYS A CB     1 ? 
ATOM   3629 C CG     A LYS A 1 234 ? 3.282   2.913   3.41    0.5  29.98  ? 1242 LYS A CG     1 ? 
ATOM   3630 C CG     B LYS A 1 234 ? 6.078   4.871   2.501   0.5  30.741 ? 1242 LYS A CG     1 ? 
ATOM   3631 C CD     A LYS A 1 234 ? 1.899   2.828   4.055   0.5  31.099 ? 1242 LYS A CD     1 ? 
ATOM   3632 C CD     B LYS A 1 234 ? 5.31    6.069   1.948   0.5  33.052 ? 1242 LYS A CD     1 ? 
ATOM   3633 C CE     A LYS A 1 234 ? 1.52    3.915   5.006   0.5  29.436 ? 1242 LYS A CE     1 ? 
ATOM   3634 C CE     B LYS A 1 234 ? 4.298   6.648   2.912   0.5  33.344 ? 1242 LYS A CE     1 ? 
ATOM   3635 N NZ     A LYS A 1 234 ? 2.362   3.914   6.191   0.5  29.748 ? 1242 LYS A NZ     1 ? 
ATOM   3636 N NZ     B LYS A 1 234 ? 3.705   7.847   2.315   0.5  33.244 ? 1242 LYS A NZ     1 ? 
ATOM   3637 H H      A LYS A 1 234 ? 5.488   1.68    4.077   0.5  24.482 ? 1242 LYS A H      1 ? 
ATOM   3638 H H      B LYS A 1 234 ? 7.019   3.676   4.654   0.5  22.039 ? 1242 LYS A H      1 ? 
ATOM   3639 H HA     A LYS A 1 234 ? 3.556   -0.329  2.913   0.5  25.563 ? 1242 LYS A HA     1 c 
ATOM   3640 H HA     B LYS A 1 234 ? 5.527   1.498   3.237   0.5  22.623 ? 1242 LYS A HA     1 c 
ATOM   3641 H HB2    A LYS A 1 234 ? 4.037   2.238   1.507   0.5  28.686 ? 1242 LYS A HB2    1 c 
ATOM   3642 H HB2    B LYS A 1 234 ? 4.706   3.339   1.85    0.5  26.094 ? 1242 LYS A HB2    1 c 
ATOM   3643 H HB3    A LYS A 1 234 ? 2.496   1.519   1.963   0.5  28.686 ? 1242 LYS A HB3    1 c 
ATOM   3644 H HB3    B LYS A 1 234 ? 4.511   3.815   3.542   0.5  26.094 ? 1242 LYS A HB3    1 c 
ATOM   3645 H HG2    A LYS A 1 234 ? 4.049   2.805   4.18    0.5  30.12  ? 1242 LYS A HG2    1 c 
ATOM   3646 H HG2    B LYS A 1 234 ? 6.553   5.165   3.439   0.5  30.036 ? 1242 LYS A HG2    1 c 
ATOM   3647 H HG3    A LYS A 1 234 ? 3.403   3.89    2.937   0.5  30.12  ? 1242 LYS A HG3    1 c 
ATOM   3648 H HG3    B LYS A 1 234 ? 6.876   4.615   1.8     0.5  30.036 ? 1242 LYS A HG3    1 c 
ATOM   3649 H HD2    A LYS A 1 234 ? 1.159   2.798   3.255   0.5  30.496 ? 1242 LYS A HD2    1 c 
ATOM   3650 H HD2    B LYS A 1 234 ? 6.024   6.848   1.676   0.5  32.598 ? 1242 LYS A HD2    1 c 
ATOM   3651 H HD3    A LYS A 1 234 ? 1.841   1.875   4.583   0.5  30.483 ? 1242 LYS A HD3    1 c 
ATOM   3652 H HD3    B LYS A 1 234 ? 4.792   5.762   1.036   0.5  32.598 ? 1242 LYS A HD3    1 c 
ATOM   3653 H HE2    A LYS A 1 234 ? 1.574   4.889   4.516   0.5  29.864 ? 1242 LYS A HE2    1 c 
ATOM   3654 H HE2    B LYS A 1 234 ? 3.513   5.917   3.117   0.5  33.258 ? 1242 LYS A HE2    1 c 
ATOM   3655 H HE3    A LYS A 1 234 ? 0.497   3.73    5.33    0.5  29.87  ? 1242 LYS A HE3    1 c 
ATOM   3656 H HE3    B LYS A 1 234 ? 4.786   6.913   3.852   0.5  33.258 ? 1242 LYS A HE3    1 c 
ATOM   3657 H HZ1    A LYS A 1 234 ? 2.004   4.543   6.911   0.5  29.884 ? 1242 LYS A HZ1    1 ? 
ATOM   3658 H HZ1    B LYS A 1 234 ? 4.422   8.552   2.15    0.5  32.787 ? 1242 LYS A HZ1    1 ? 
ATOM   3659 H HZ2    A LYS A 1 234 ? 2.341   2.956   6.543   0.5  29.922 ? 1242 LYS A HZ2    1 ? 
ATOM   3660 H HZ2    B LYS A 1 234 ? 3.29    7.6     1.419   0.5  32.795 ? 1242 LYS A HZ2    1 ? 
ATOM   3661 H HZ3    A LYS A 1 234 ? 3.312   4.186   5.943   0.5  30.685 ? 1242 LYS A HZ3    1 ? 
ATOM   3662 H HZ3    B LYS A 1 234 ? 2.98    8.253   2.905   0.5  31.627 ? 1242 LYS A HZ3    1 ? 
ATOM   3663 N N      A ASN A 1 235 ? 5.059   -0.629  0.799   0.63 26.187 ? 1243 ASN A N      1 ? 
ATOM   3664 N N      B ASN A 1 235 ? 7.133   1.407   1.21    0.37 20.985 ? 1243 ASN A N      1 ? 
ATOM   3665 C CA     A ASN A 1 235 ? 6.037   -0.896  -0.254  0.63 26.106 ? 1243 ASN A CA     1 ? 
ATOM   3666 C CA     B ASN A 1 235 ? 8.178   1.316   0.211   0.37 20.941 ? 1243 ASN A CA     1 ? 
ATOM   3667 C C      A ASN A 1 235 ? 5.843   0.099   -1.396  0.63 28.555 ? 1243 ASN A C      1 ? 
ATOM   3668 C C      B ASN A 1 235 ? 8.015   2.431   -0.812  0.37 22.507 ? 1243 ASN A C      1 ? 
ATOM   3669 O O      A ASN A 1 235 ? 4.89    0.878   -1.399  0.63 31.129 ? 1243 ASN A O      1 ? 
ATOM   3670 O O      B ASN A 1 235 ? 7.119   3.266   -0.708  0.37 22.616 ? 1243 ASN A O      1 ? 
ATOM   3671 C CB     A ASN A 1 235 ? 6.028   -2.355  -0.701  0.63 23.234 ? 1243 ASN A CB     1 ? 
ATOM   3672 C CB     B ASN A 1 235 ? 8.234   -0.046  -0.468  0.37 20.441 ? 1243 ASN A CB     1 ? 
ATOM   3673 C CG     A ASN A 1 235 ? 4.73    -2.793  -1.33   0.63 24.953 ? 1243 ASN A CG     1 ? 
ATOM   3674 C CG     B ASN A 1 235 ? 9.52    -0.202  -1.248  0.37 20.94  ? 1243 ASN A CG     1 ? 
ATOM   3675 O OD1    A ASN A 1 235 ? 4.186   -2.082  -2.185  0.63 25.828 ? 1243 ASN A OD1    1 ? 
ATOM   3676 O OD1    B ASN A 1 235 ? 10.51   0.501   -0.996  0.37 18.616 ? 1243 ASN A OD1    1 ? 
ATOM   3677 N ND2    A ASN A 1 235 ? 4.196   -3.95   -0.93   0.63 24.906 ? 1243 ASN A ND2    1 ? 
ATOM   3678 N ND2    B ASN A 1 235 ? 9.536   -1.148  -2.173  0.37 20.387 ? 1243 ASN A ND2    1 ? 
ATOM   3679 H H      A ASN A 1 235 ? 4.177   -1.166  0.803   0.63 24.91  ? 1243 ASN A H      1 ? 
ATOM   3680 H H      B ASN A 1 235 ? 6.281   0.825   1.116   0.37 18.698 ? 1243 ASN A H      1 ? 
ATOM   3681 H HA     A ASN A 1 235 ? 7.025   -0.707  0.166   0.63 25.964 ? 1243 ASN A HA     1 c 
ATOM   3682 H HA     B ASN A 1 235 ? 9.135   1.462   0.718   0.37 21.128 ? 1243 ASN A HA     1 c 
ATOM   3683 H HB2    A ASN A 1 235 ? 6.833   -2.504  -1.423  0.63 24.23  ? 1243 ASN A HB2    1 c 
ATOM   3684 H HB2    B ASN A 1 235 ? 8.17    -0.832  0.287   0.37 20.658 ? 1243 ASN A HB2    1 c 
ATOM   3685 H HB3    A ASN A 1 235 ? 6.236   -2.99   0.161   0.63 24.311 ? 1243 ASN A HB3    1 c 
ATOM   3686 H HB3    B ASN A 1 235 ? 7.384   -0.15   -1.145  0.37 20.657 ? 1243 ASN A HB3    1 c 
ATOM   3687 H HD21   A ASN A 1 235 ? 3.375   -4.286  -1.416  0.63 24.735 ? 1243 ASN A HD21   1 ? 
ATOM   3688 H HD21   B ASN A 1 235 ? 10.325  -1.199  -2.796  0.37 20.884 ? 1243 ASN A HD21   1 ? 
ATOM   3689 H HD22   A ASN A 1 235 ? 4.559   -4.51   -0.174  0.63 24.087 ? 1243 ASN A HD22   1 ? 
ATOM   3690 H HD22   B ASN A 1 235 ? 8.76    -1.785  -2.269  0.37 19.947 ? 1243 ASN A HD22   1 ? 
ATOM   3691 N N      A ARG A 1 236 ? 6.771   0.06    -2.353  0.63 31.688 ? 1244 ARG A N      1 ? 
ATOM   3692 N N      B ARG A 1 236 ? 8.904   2.416   -1.809  0.37 24.919 ? 1244 ARG A N      1 ? 
ATOM   3693 C CA     A ARG A 1 236 ? 6.715   0.884   -3.559  0.63 35.63  ? 1244 ARG A CA     1 ? 
ATOM   3694 C CA     B ARG A 1 236 ? 9.111   3.571   -2.674  0.37 27.046 ? 1244 ARG A CA     1 ? 
ATOM   3695 C C      A ARG A 1 236 ? 5.366   0.781   -4.275  0.63 37.84  ? 1244 ARG A C      1 ? 
ATOM   3696 C C      B ARG A 1 236 ? 7.928   3.764   -3.623  0.37 26.102 ? 1244 ARG A C      1 ? 
ATOM   3697 O O      A ARG A 1 236 ? 4.956   1.755   -4.9    0.63 36.735 ? 1244 ARG A O      1 ? 
ATOM   3698 O O      B ARG A 1 236 ? 7.826   4.804   -4.273  0.37 25.773 ? 1244 ARG A O      1 ? 
ATOM   3699 C CB     A ARG A 1 236 ? 7.806   0.623   -4.614  0.63 35.299 ? 1244 ARG A CB     1 ? 
ATOM   3700 C CB     B ARG A 1 236 ? 10.438  3.447   -3.431  0.37 26.948 ? 1244 ARG A CB     1 ? 
ATOM   3701 C CG     A ARG A 1 236 ? 8.504   -0.725  -4.718  0.63 41.782 ? 1244 ARG A CG     1 ? 
ATOM   3702 C CG     B ARG A 1 236 ? 11.617  3.456   -2.47   0.37 29.83  ? 1244 ARG A CG     1 ? 
ATOM   3703 C CD     A ARG A 1 236 ? 8.034   -1.678  -5.824  0.63 46.87  ? 1244 ARG A CD     1 ? 
ATOM   3704 C CD     B ARG A 1 236 ? 12.981  3.383   -3.135  0.37 30.462 ? 1244 ARG A CD     1 ? 
ATOM   3705 N NE     A ARG A 1 236 ? 6.939   -2.578  -5.431  0.63 49.048 ? 1244 ARG A NE     1 ? 
ATOM   3706 N NE     B ARG A 1 236 ? 13.988  3.216   -2.083  0.37 31.544 ? 1244 ARG A NE     1 ? 
ATOM   3707 C CZ     A ARG A 1 236 ? 6.95    -3.528  -4.483  0.63 50.648 ? 1244 ARG A CZ     1 ? 
ATOM   3708 C CZ     B ARG A 1 236 ? 15.111  2.532   -2.192  0.37 30.965 ? 1244 ARG A CZ     1 ? 
ATOM   3709 N NH1    A ARG A 1 236 ? 7.957   -3.647  -3.614  0.63 48.744 ? 1244 ARG A NH1    1 ? 
ATOM   3710 N NH1    B ARG A 1 236 ? 15.385  1.932   -3.33   0.37 31.522 ? 1244 ARG A NH1    1 ? 
ATOM   3711 N NH2    A ARG A 1 236 ? 5.896   -4.327  -4.367  0.63 49.35  ? 1244 ARG A NH2    1 ? 
ATOM   3712 N NH2    B ARG A 1 236 ? 15.938  2.458   -1.165  0.37 29.669 ? 1244 ARG A NH2    1 ? 
ATOM   3713 H H      A ARG A 1 236 ? 7.584   -0.566  -2.217  0.63 31.949 ? 1244 ARG A H      1 ? 
ATOM   3714 H H      B ARG A 1 236 ? 9.478   1.565   -1.957  0.37 21.707 ? 1244 ARG A H      1 ? 
ATOM   3715 H HA     A ARG A 1 236 ? 6.835   1.922   -3.244  0.63 35.165 ? 1244 ARG A HA     1 c 
ATOM   3716 H HA     B ARG A 1 236 ? 9.177   4.456   -2.036  0.37 26.446 ? 1244 ARG A HA     1 c 
ATOM   3717 H HB2    A ARG A 1 236 ? 7.365   0.836   -5.59   0.63 36.725 ? 1244 ARG A HB2    1 c 
ATOM   3718 H HB2    B ARG A 1 236 ? 10.445  2.517   -4.003  0.37 27.575 ? 1244 ARG A HB2    1 c 
ATOM   3719 H HB3    A ARG A 1 236 ? 8.581   1.376   -4.455  0.63 36.719 ? 1244 ARG A HB3    1 c 
ATOM   3720 H HB3    B ARG A 1 236 ? 10.536  4.279   -4.131  0.37 27.575 ? 1244 ARG A HB3    1 c 
ATOM   3721 H HG2    A ARG A 1 236 ? 9.572   -0.543  -4.858  0.63 41.107 ? 1244 ARG A HG2    1 c 
ATOM   3722 H HG2    B ARG A 1 236 ? 11.571  4.366   -1.867  0.37 29.309 ? 1244 ARG A HG2    1 c 
ATOM   3723 H HG3    A ARG A 1 236 ? 8.406   -1.234  -3.76   0.63 41.17  ? 1244 ARG A HG3    1 c 
ATOM   3724 H HG3    B ARG A 1 236 ? 11.518  2.611   -1.785  0.37 29.309 ? 1244 ARG A HG3    1 c 
ATOM   3725 H HD2    A ARG A 1 236 ? 7.71    -1.08   -6.679  0.63 46.176 ? 1244 ARG A HD2    1 c 
ATOM   3726 H HD2    B ARG A 1 236 ? 13.024  2.536   -3.823  0.37 30.565 ? 1244 ARG A HD2    1 c 
ATOM   3727 H HD3    A ARG A 1 236 ? 8.886   -2.278  -6.147  0.63 46.116 ? 1244 ARG A HD3    1 c 
ATOM   3728 H HD3    B ARG A 1 236 ? 13.18   4.3     -3.693  0.37 30.565 ? 1244 ARG A HD3    1 c 
ATOM   3729 H HE     A ARG A 1 236 ? 6.065   -2.455  -5.91   0.63 48.524 ? 1244 ARG A HE     1 ? 
ATOM   3730 H HE     B ARG A 1 236 ? 13.801  3.639   -1.182  0.37 31.582 ? 1244 ARG A HE     1 ? 
ATOM   3731 H HH11   A ARG A 1 236 ? 8.718   -2.969  -3.584  0.63 41.771 ? 1244 ARG A HH11   1 ? 
ATOM   3732 H HH11   B ARG A 1 236 ? 14.701  2.012   -4.074  0.37 33.212 ? 1244 ARG A HH11   1 ? 
ATOM   3733 H HH12   A ARG A 1 236 ? 7.946   -4.415  -2.939  0.63 46.144 ? 1244 ARG A HH12   1 ? 
ATOM   3734 H HH12   B ARG A 1 236 ? 16.24   1.392   -3.451  0.37 31.167 ? 1244 ARG A HH12   1 ? 
ATOM   3735 H HH21   A ARG A 1 236 ? 5.048   -4.169  -4.907  0.63 44.955 ? 1244 ARG A HH21   1 ? 
ATOM   3736 H HH21   B ARG A 1 236 ? 15.715  2.95    -0.305  0.37 30.216 ? 1244 ARG A HH21   1 ? 
ATOM   3737 H HH22   A ARG A 1 236 ? 5.947   -5.096  -3.713  0.63 48.079 ? 1244 ARG A HH22   1 ? 
ATOM   3738 H HH22   B ARG A 1 236 ? 16.788  1.915   -1.234  0.37 30.743 ? 1244 ARG A HH22   1 ? 
ATOM   3739 N N      A SER A 1 237 ? 4.717   -0.391  -4.227  0.63 37.335 ? 1245 SER A N      1 ? 
ATOM   3740 N N      B SER A 1 237 ? 7.029   2.775   -3.698  0.37 25.145 ? 1245 SER A N      1 ? 
ATOM   3741 C CA     A SER A 1 237 ? 3.472   -0.598  -4.944  0.63 39.577 ? 1245 SER A CA     1 ? 
ATOM   3742 C CA     B SER A 1 237 ? 5.786   2.945   -4.434  0.37 25.923 ? 1245 SER A CA     1 ? 
ATOM   3743 C C      A SER A 1 237 ? 2.313   -0.191  -4.04   0.63 41.704 ? 1245 SER A C      1 ? 
ATOM   3744 C C      B SER A 1 237 ? 4.767   3.644   -3.54   0.37 25.938 ? 1245 SER A C      1 ? 
ATOM   3745 O O      A SER A 1 237 ? 1.244   0.179   -4.522  0.63 42.659 ? 1245 SER A O      1 ? 
ATOM   3746 O O      B SER A 1 237 ? 3.947   4.428   -4.02   0.37 25.745 ? 1245 SER A O      1 ? 
ATOM   3747 C CB     A SER A 1 237 ? 3.328   -2.03   -5.419  0.63 38.172 ? 1245 SER A CB     1 ? 
ATOM   3748 C CB     B SER A 1 237 ? 5.244   1.627   -4.922  0.37 26.511 ? 1245 SER A CB     1 ? 
ATOM   3749 O OG     A SER A 1 237 ? 4.505   -2.453  -6.095  0.63 38.199 ? 1245 SER A OG     1 ? 
ATOM   3750 O OG     B SER A 1 237 ? 6.28    0.778   -5.399  0.37 27.977 ? 1245 SER A OG     1 ? 
ATOM   3751 H H      A SER A 1 237 ? 5.102   -1.174  -3.668  0.63 37.533 ? 1245 SER A H      1 ? 
ATOM   3752 H H      B SER A 1 237 ? 7.2     1.88    -3.208  0.37 24.646 ? 1245 SER A H      1 ? 
ATOM   3753 H HA     A SER A 1 237 ? 3.469   0.055   -5.819  0.63 39.239 ? 1245 SER A HA     1 c 
ATOM   3754 H HA     B SER A 1 237 ? 5.983   3.583   -5.298  0.37 25.882 ? 1245 SER A HA     1 c 
ATOM   3755 H HB2    A SER A 1 237 ? 3.147   -2.681  -4.56   0.63 38.476 ? 1245 SER A HB2    1 c 
ATOM   3756 H HB2    B SER A 1 237 ? 4.718   1.13    -4.104  0.37 26.714 ? 1245 SER A HB2    1 c 
ATOM   3757 H HB3    A SER A 1 237 ? 2.472   -2.105  -6.093  0.63 38.476 ? 1245 SER A HB3    1 c 
ATOM   3758 H HB3    B SER A 1 237 ? 4.526   1.808   -5.725  0.37 26.714 ? 1245 SER A HB3    1 c 
ATOM   3759 H HG     A SER A 1 237 ? 4.77    -1.753  -6.72   0.63 38.561 ? 1245 SER A HG     1 ? 
ATOM   3760 H HG     B SER A 1 237 ? 5.9     -0.094  -5.591  0.37 27.819 ? 1245 SER A HG     1 ? 
ATOM   3761 N N      A GLY A 1 238 ? 2.535   -0.298  -2.725  0.63 40.128 ? 1246 GLY A N      1 ? 
ATOM   3762 N N      B GLY A 1 238 ? 4.842   3.333   -2.24   0.37 23.136 ? 1246 GLY A N      1 ? 
ATOM   3763 C CA     A GLY A 1 238 ? 1.568   0.152   -1.744  0.63 36.585 ? 1246 GLY A CA     1 ? 
ATOM   3764 C CA     B GLY A 1 238 ? 3.93    3.86    -1.243  0.37 21.669 ? 1246 GLY A CA     1 ? 
ATOM   3765 C C      A GLY A 1 238 ? 0.83    -1.004  -1.07   0.63 34.525 ? 1246 GLY A C      1 ? 
ATOM   3766 C C      B GLY A 1 238 ? 3.256   2.735   -0.464  0.37 20.036 ? 1246 GLY A C      1 ? 
ATOM   3767 O O      A GLY A 1 238 ? -0.225  -0.776  -0.488  0.63 31.365 ? 1246 GLY A O      1 ? 
ATOM   3768 O O      B GLY A 1 238 ? 2.542   2.992   0.501   0.37 19.658 ? 1246 GLY A O      1 ? 
ATOM   3769 H H      A GLY A 1 238 ? 3.414   -0.731  -2.39   0.63 39.87  ? 1246 GLY A H      1 ? 
ATOM   3770 H H      B GLY A 1 238 ? 5.592   2.688   -1.928  0.37 22.691 ? 1246 GLY A H      1 ? 
ATOM   3771 H HA2    A GLY A 1 238 ? 2.082   0.746   -0.986  0.63 36.883 ? 1246 GLY A HA2    1 c 
ATOM   3772 H HA2    B GLY A 1 238 ? 4.485   4.501   -0.554  0.37 21.619 ? 1246 GLY A HA2    1 c 
ATOM   3773 H HA3    A GLY A 1 238 ? 0.842   0.799   -2.24   0.63 36.783 ? 1246 GLY A HA3    1 c 
ATOM   3774 H HA3    B GLY A 1 238 ? 3.171   4.471   -1.736  0.37 21.575 ? 1246 GLY A HA3    1 c 
ATOM   3775 N N      A GLY A 1 239 ? 1.397   -2.22   -1.091  0.63 32.36  ? 1247 GLY A N      1 ? 
ATOM   3776 N N      B GLY A 1 239 ? 3.479   1.487   -0.897  0.37 19.867 ? 1247 GLY A N      1 ? 
ATOM   3777 C CA     A GLY A 1 239 ? 0.875   -3.325  -0.294  0.63 27.428 ? 1247 GLY A CA     1 ? 
ATOM   3778 C CA     B GLY A 1 239 ? 2.83    0.316   -0.315  0.37 18.487 ? 1247 GLY A CA     1 ? 
ATOM   3779 C C      A GLY A 1 239 ? 1.822   -3.635  0.862   0.63 29.379 ? 1247 GLY A C      1 ? 
ATOM   3780 C C      B GLY A 1 239 ? 3.385   -0.03   1.072   0.37 19.853 ? 1247 GLY A C      1 ? 
ATOM   3781 O O      A GLY A 1 239 ? 3.002   -3.918  0.625   0.63 29.47  ? 1247 GLY A O      1 ? 
ATOM   3782 O O      B GLY A 1 239 ? 4.28    0.652   1.564   0.37 18.199 ? 1247 GLY A O      1 ? 
ATOM   3783 H H      A GLY A 1 239 ? 2.247   -2.374  -1.668  0.63 31.744 ? 1247 GLY A H      1 ? 
ATOM   3784 H H      B GLY A 1 239 ? 4.152   1.353   -1.669  0.37 20.172 ? 1247 GLY A H      1 ? 
ATOM   3785 H HA2    A GLY A 1 239 ? -0.111  -3.068  0.094   0.63 28.889 ? 1247 GLY A HA2    1 c 
ATOM   3786 H HA2    B GLY A 1 239 ? 1.757   0.507   -0.238  0.37 19.077 ? 1247 GLY A HA2    1 c 
ATOM   3787 H HA3    A GLY A 1 239 ? 0.771   -4.207  -0.93   0.63 28.914 ? 1247 GLY A HA3    1 c 
ATOM   3788 H HA3    B GLY A 1 239 ? 2.971   -0.535  -0.984  0.37 19.062 ? 1247 GLY A HA3    1 c 
ATOM   3789 N N      A LYS A 1 240 ? 1.302   -3.581  2.098   0.5  25.141 ? 1248 LYS A N      1 ? 
ATOM   3790 N N      B LYS A 1 240 ? 2.879   -1.11   1.697   0.5  20.768 ? 1248 LYS A N      1 ? 
ATOM   3791 C CA     A LYS A 1 240 ? 2.07    -3.697  3.345   0.5  26.271 ? 1248 LYS A CA     1 ? 
ATOM   3792 C CA     B LYS A 1 240 ? 3.334   -1.469  3.021   0.5  23.269 ? 1248 LYS A CA     1 ? 
ATOM   3793 C C      A LYS A 1 240 ? 3.532   -4.122  3.12    0.5  24.418 ? 1248 LYS A C      1 ? 
ATOM   3794 C C      B LYS A 1 240 ? 4.669   -2.202  2.809   0.5  20.468 ? 1248 LYS A C      1 ? 
ATOM   3795 O O      A LYS A 1 240 ? 3.817   -4.931  2.235   0.5  23.039 ? 1248 LYS A O      1 ? 
ATOM   3796 O O      B LYS A 1 240 ? 4.851   -2.849  1.784   0.5  23.039 ? 1248 LYS A O      1 ? 
ATOM   3797 C CB     A LYS A 1 240 ? 1.35    -4.649  4.32    0.5  26.978 ? 1248 LYS A CB     1 ? 
ATOM   3798 C CB     B LYS A 1 240 ? 2.207   -2.212  3.763   0.5  24.596 ? 1248 LYS A CB     1 ? 
ATOM   3799 C CG     A LYS A 1 240 ? 0.323   -3.99   5.255   0.5  28.848 ? 1248 LYS A CG     1 ? 
ATOM   3800 C CG     B LYS A 1 240 ? 0.854   -1.498  3.735   0.5  29.462 ? 1248 LYS A CG     1 ? 
ATOM   3801 C CD     A LYS A 1 240 ? -0.301  -4.856  6.352   0.5  31.182 ? 1248 LYS A CD     1 ? 
ATOM   3802 C CD     B LYS A 1 240 ? -0.278  -2.099  4.577   0.5  30.841 ? 1248 LYS A CD     1 ? 
ATOM   3803 C CE     A LYS A 1 240 ? -1.095  -3.97   7.307   0.5  35.946 ? 1248 LYS A CE     1 ? 
ATOM   3804 C CE     B LYS A 1 240 ? -1.566  -1.285  4.528   0.5  29.914 ? 1248 LYS A CE     1 ? 
ATOM   3805 N NZ     A LYS A 1 240 ? -2.07   -4.638  8.186   0.5  40.868 ? 1248 LYS A NZ     1 ? 
ATOM   3806 N NZ     B LYS A 1 240 ? -2.746  -2.143  4.718   0.5  31.58  ? 1248 LYS A NZ     1 ? 
ATOM   3807 H H      A LYS A 1 240 ? 0.277   -3.467  2.175   0.5  25.703 ? 1248 LYS A H      1 ? 
ATOM   3808 H H      B LYS A 1 240 ? 2.25    -1.767  1.215   0.5  19.207 ? 1248 LYS A H      1 ? 
ATOM   3809 H HA     A LYS A 1 240 ? 2.083   -2.711  3.814   0.5  25.841 ? 1248 LYS A HA     1 c 
ATOM   3810 H HA     B LYS A 1 240 ? 3.533   -0.543  3.548   0.5  22.48  ? 1248 LYS A HA     1 c 
ATOM   3811 H HB2    A LYS A 1 240 ? 0.84    -5.419  3.738   0.5  27.218 ? 1248 LYS A HB2    1 c 
ATOM   3812 H HB2    B LYS A 1 240 ? 2.084   -3.202  3.321   0.5  25.277 ? 1248 LYS A HB2    1 c 
ATOM   3813 H HB3    A LYS A 1 240 ? 2.103   -5.147  4.936   0.5  27.218 ? 1248 LYS A HB3    1 c 
ATOM   3814 H HB3    B LYS A 1 240 ? 2.495   -2.349  4.805   0.5  25.226 ? 1248 LYS A HB3    1 c 
ATOM   3815 H HG2    A LYS A 1 240 ? 0.802   -3.131  5.727   0.5  28.889 ? 1248 LYS A HG2    1 c 
ATOM   3816 H HG2    B LYS A 1 240 ? 1.02    -0.473  4.064   0.5  28.6   ? 1248 LYS A HG2    1 c 
ATOM   3817 H HG3    A LYS A 1 240 ? -0.485  -3.595  4.634   0.5  28.911 ? 1248 LYS A HG3    1 c 
ATOM   3818 H HG3    B LYS A 1 240 ? 0.521   -1.449  2.696   0.5  28.607 ? 1248 LYS A HG3    1 c 
ATOM   3819 H HD2    A LYS A 1 240 ? -0.967  -5.594  5.9     0.5  31.78  ? 1248 LYS A HD2    1 c 
ATOM   3820 H HD2    B LYS A 1 240 ? -0.484  -3.109  4.218   0.5  30.35  ? 1248 LYS A HD2    1 c 
ATOM   3821 H HD3    A LYS A 1 240 ? 0.487   -5.373  6.904   0.5  31.774 ? 1248 LYS A HD3    1 c 
ATOM   3822 H HD3    B LYS A 1 240 ? 0.055   -2.176  5.614   0.5  30.416 ? 1248 LYS A HD3    1 c 
ATOM   3823 H HE2    A LYS A 1 240 ? -0.391  -3.422  7.934   0.5  35.74  ? 1248 LYS A HE2    1 c 
ATOM   3824 H HE2    B LYS A 1 240 ? -1.559  -0.55   5.334   0.5  30.496 ? 1248 LYS A HE2    1 c 
ATOM   3825 H HE3    A LYS A 1 240 ? -1.634  -3.231  6.71    0.5  35.853 ? 1248 LYS A HE3    1 c 
ATOM   3826 H HE3    B LYS A 1 240 ? -1.652  -0.775  3.568   0.5  30.499 ? 1248 LYS A HE3    1 c 
ATOM   3827 H HZ1    A LYS A 1 240 ? -2.592  -3.948  8.726   0.5  40.157 ? 1248 LYS A HZ1    1 ? 
ATOM   3828 H HZ1    B LYS A 1 240 ? -3.553  -1.75   4.24    0.5  30.795 ? 1248 LYS A HZ1    1 ? 
ATOM   3829 H HZ2    A LYS A 1 240 ? -2.719  -5.139  7.59    0.5  37.542 ? 1248 LYS A HZ2    1 ? 
ATOM   3830 H HZ2    B LYS A 1 240 ? -2.527  -3.051  4.316   0.5  30.047 ? 1248 LYS A HZ2    1 ? 
ATOM   3831 H HZ3    A LYS A 1 240 ? -1.648  -5.298  8.847   0.5  39.357 ? 1248 LYS A HZ3    1 ? 
ATOM   3832 H HZ3    B LYS A 1 240 ? -2.96   -2.302  5.711   0.5  30.887 ? 1248 LYS A HZ3    1 ? 
ATOM   3833 N N      A MET A 1 241 ? 4.447   -3.622  3.977   0.63 22.154 ? 1249 MET A N      1 ? 
ATOM   3834 N N      B MET A 1 241 ? 5.612   -2.076  3.756   0.37 18.646 ? 1249 MET A N      1 ? 
ATOM   3835 C CA     A MET A 1 241 ? 5.876   -3.775  3.762   0.63 24.899 ? 1249 MET A CA     1 ? 
ATOM   3836 C CA     B MET A 1 241 ? 6.956   -2.632  3.611   0.37 18.188 ? 1249 MET A CA     1 ? 
ATOM   3837 C C      A MET A 1 241 ? 6.292   -5.131  4.307   0.63 24.364 ? 1249 MET A C      1 ? 
ATOM   3838 C C      B MET A 1 241 ? 7.059   -4.045  4.202   0.37 17.202 ? 1249 MET A C      1 ? 
ATOM   3839 O O      A MET A 1 241 ? 6.334   -5.363  5.522   0.63 21.962 ? 1249 MET A O      1 ? 
ATOM   3840 O O      B MET A 1 241 ? 6.941   -4.205  5.416   0.37 17.575 ? 1249 MET A O      1 ? 
ATOM   3841 C CB     A MET A 1 241 ? 6.709   -2.658  4.405   0.63 24.043 ? 1249 MET A CB     1 ? 
ATOM   3842 C CB     B MET A 1 241 ? 7.963   -1.712  4.311   0.37 19.111 ? 1249 MET A CB     1 ? 
ATOM   3843 C CG     A MET A 1 241 ? 8.115   -2.597  3.888   0.63 23.78  ? 1249 MET A CG     1 ? 
ATOM   3844 C CG     B MET A 1 241 ? 9.348   -1.704  3.679   0.37 20.125 ? 1249 MET A CG     1 ? 
ATOM   3845 S SD     A MET A 1 241 ? 8.21    -2.113  2.154   0.63 24.355 ? 1249 MET A SD     1 ? 
ATOM   3846 S SD     B MET A 1 241 ? 9.618   -0.364  2.498   0.37 22.641 ? 1249 MET A SD     1 ? 
ATOM   3847 C CE     A MET A 1 241 ? 9.953   -2.36   1.784   0.63 24.477 ? 1249 MET A CE     1 ? 
ATOM   3848 C CE     B MET A 1 241 ? 10.03   1.123   3.431   0.37 25.768 ? 1249 MET A CE     1 ? 
ATOM   3849 H H      A MET A 1 241 ? 4.135   -3.163  4.852   0.63 23.075 ? 1249 MET A H      1 ? 
ATOM   3850 H H      B MET A 1 241 ? 5.398   -1.525  4.605   0.37 17.701 ? 1249 MET A H      1 ? 
ATOM   3851 H HA     A MET A 1 241 ? 6.069   -3.792  2.69    0.63 24.037 ? 1249 MET A HA     1 c 
ATOM   3852 H HA     B MET A 1 241 ? 7.191   -2.683  2.546   0.37 18.252 ? 1249 MET A HA     1 c 
ATOM   3853 H HB2    A MET A 1 241 ? 6.224   -1.698  4.225   0.63 24.128 ? 1249 MET A HB2    1 c 
ATOM   3854 H HB2    B MET A 1 241 ? 7.566   -0.694  4.304   0.37 19.121 ? 1249 MET A HB2    1 c 
ATOM   3855 H HB3    A MET A 1 241 ? 6.735   -2.819  5.485   0.63 24.146 ? 1249 MET A HB3    1 c 
ATOM   3856 H HB3    B MET A 1 241 ? 8.053   -2.025  5.353   0.37 19.121 ? 1249 MET A HB3    1 c 
ATOM   3857 H HG2    A MET A 1 241 ? 8.685   -1.88   4.482   0.63 23.937 ? 1249 MET A HG2    1 c 
ATOM   3858 H HG2    B MET A 1 241 ? 10.098  -1.636  4.463   0.37 20.682 ? 1249 MET A HG2    1 c 
ATOM   3859 H HG3    A MET A 1 241 ? 8.584   -3.576  4.004   0.63 23.906 ? 1249 MET A HG3    1 c 
ATOM   3860 H HG3    B MET A 1 241 ? 9.502   -2.653  3.16    0.37 20.398 ? 1249 MET A HG3    1 c 
ATOM   3861 H HE1    A MET A 1 241 ? 10.129  -2.175  0.723   0.63 24.454 ? 1249 MET A HE1    1 c 
ATOM   3862 H HE1    B MET A 1 241 ? 9.918   1.997   2.785   0.37 25.084 ? 1249 MET A HE1    1 c 
ATOM   3863 H HE2    A MET A 1 241 ? 10.551  -1.666  2.379   0.63 24.454 ? 1249 MET A HE2    1 c 
ATOM   3864 H HE2    B MET A 1 241 ? 9.36    1.213   4.287   0.37 25.208 ? 1249 MET A HE2    1 c 
ATOM   3865 H HE3    A MET A 1 241 ? 10.236  -3.385  2.028   0.63 24.474 ? 1249 MET A HE3    1 c 
ATOM   3866 H HE3    B MET A 1 241 ? 11.063  1.059   3.779   0.37 25.234 ? 1249 MET A HE3    1 c 
ATOM   3867 N N      A TYR A 1 242 ? 6.556   -6.021  3.355   0.63 21.241 ? 1250 TYR A N      1 ? 
ATOM   3868 N N      B TYR A 1 242 ? 7.281   -5.062  3.342   0.37 17.391 ? 1250 TYR A N      1 ? 
ATOM   3869 C CA     A TYR A 1 242 ? 7.145   -7.293  3.677   0.63 21.99  ? 1250 TYR A CA     1 ? 
ATOM   3870 C CA     B TYR A 1 242 ? 7.443   -6.468  3.748   0.37 19.188 ? 1250 TYR A CA     1 ? 
ATOM   3871 C C      A TYR A 1 242 ? 8.626   -7.205  3.301   0.63 21.403 ? 1250 TYR A C      1 ? 
ATOM   3872 C C      B TYR A 1 242 ? 8.898   -6.912  3.522   0.37 19.431 ? 1250 TYR A C      1 ? 
ATOM   3873 O O      A TYR A 1 242 ? 9.085   -6.358  2.536   0.63 21.542 ? 1250 TYR A O      1 ? 
ATOM   3874 O O      B TYR A 1 242 ? 9.66    -6.097  2.996   0.37 19.558 ? 1250 TYR A O      1 ? 
ATOM   3875 C CB     A TYR A 1 242 ? 6.285   -8.408  3.064   0.63 23.695 ? 1250 TYR A CB     1 ? 
ATOM   3876 C CB     B TYR A 1 242 ? 6.483   -7.37   2.97    0.37 19.873 ? 1250 TYR A CB     1 ? 
ATOM   3877 C CG     A TYR A 1 242 ? 4.87    -8.443  3.62    0.63 24.079 ? 1250 TYR A CG     1 ? 
ATOM   3878 C CG     B TYR A 1 242 ? 4.997   -7.172  3.242   0.37 20.604 ? 1250 TYR A CG     1 ? 
ATOM   3879 C CD1    A TYR A 1 242 ? 4.635   -8.754  4.957   0.63 24.672 ? 1250 TYR A CD1    1 ? 
ATOM   3880 C CD1    B TYR A 1 242 ? 4.483   -7.209  4.534   0.37 20.542 ? 1250 TYR A CD1    1 ? 
ATOM   3881 C CD2    A TYR A 1 242 ? 3.769   -8.197  2.801   0.63 24.32  ? 1250 TYR A CD2    1 ? 
ATOM   3882 C CD2    B TYR A 1 242 ? 4.104   -6.953  2.197   0.37 21.196 ? 1250 TYR A CD2    1 ? 
ATOM   3883 C CE1    A TYR A 1 242 ? 3.35    -8.799  5.468   0.63 25.605 ? 1250 TYR A CE1    1 ? 
ATOM   3884 C CE1    B TYR A 1 242 ? 3.131   -7.018  4.778   0.37 20.612 ? 1250 TYR A CE1    1 ? 
ATOM   3885 C CE2    A TYR A 1 242 ? 2.475   -8.231  3.301   0.63 23.944 ? 1250 TYR A CE2    1 ? 
ATOM   3886 C CE2    B TYR A 1 242 ? 2.748   -6.766  2.427   0.37 20.711 ? 1250 TYR A CE2    1 ? 
ATOM   3887 C CZ     A TYR A 1 242 ? 2.267   -8.519  4.641   0.63 25.525 ? 1250 TYR A CZ     1 ? 
ATOM   3888 C CZ     B TYR A 1 242 ? 2.261   -6.794  3.721   0.37 21.353 ? 1250 TYR A CZ     1 ? 
ATOM   3889 O OH     A TYR A 1 242 ? 1       -8.531  5.156   0.63 26.448 ? 1250 TYR A OH     1 ? 
ATOM   3890 O OH     B TYR A 1 242 ? 0.922   -6.615  3.966   0.37 21.167 ? 1250 TYR A OH     1 ? 
ATOM   3891 H H      A TYR A 1 242 ? 6.371   -5.789  2.366   0.63 22.655 ? 1250 TYR A H      1 ? 
ATOM   3892 H H      B TYR A 1 242 ? 7.345   -4.827  2.333   0.37 16.137 ? 1250 TYR A H      1 ? 
ATOM   3893 H HA     A TYR A 1 242 ? 7.094   -7.411  4.76    0.63 22.046 ? 1250 TYR A HA     1 c 
ATOM   3894 H HA     B TYR A 1 242 ? 7.214   -6.549  4.813   0.37 18.998 ? 1250 TYR A HA     1 c 
ATOM   3895 H HB2    A TYR A 1 242 ? 6.239   -8.259  1.984   0.63 23.403 ? 1250 TYR A HB2    1 c 
ATOM   3896 H HB2    B TYR A 1 242 ? 6.664   -7.223  1.905   0.37 19.973 ? 1250 TYR A HB2    1 c 
ATOM   3897 H HB3    A TYR A 1 242 ? 6.767   -9.367  3.26    0.63 23.391 ? 1250 TYR A HB3    1 c 
ATOM   3898 H HB3    B TYR A 1 242 ? 6.738   -8.408  3.195   0.37 19.897 ? 1250 TYR A HB3    1 c 
ATOM   3899 H HD1    A TYR A 1 242 ? 5.475   -8.959  5.613   0.63 24.741 ? 1250 TYR A HD1    1 c 
ATOM   3900 H HD1    B TYR A 1 242 ? 5.155   -7.373  5.37    0.37 20.576 ? 1250 TYR A HD1    1 c 
ATOM   3901 H HD2    A TYR A 1 242 ? 3.927   -7.955  1.755   0.63 24.203 ? 1250 TYR A HD2    1 c 
ATOM   3902 H HD2    B TYR A 1 242 ? 4.476   -6.923  1.179   0.37 20.95  ? 1250 TYR A HD2    1 c 
ATOM   3903 H HE1    A TYR A 1 242 ? 3.188   -9.017  6.519   0.63 25.361 ? 1250 TYR A HE1    1 c 
ATOM   3904 H HE1    B TYR A 1 242 ? 2.752   -7.045  5.795   0.37 20.757 ? 1250 TYR A HE1    1 c 
ATOM   3905 H HE2    A TYR A 1 242 ? 1.632   -8.012  2.654   0.63 24.381 ? 1250 TYR A HE2    1 c 
ATOM   3906 H HE2    B TYR A 1 242 ? 2.072   -6.593  1.596   0.37 20.948 ? 1250 TYR A HE2    1 c 
ATOM   3907 H HH     A TYR A 1 242 ? 0.357   -8.224  4.496   0.63 26.12  ? 1250 TYR A HH     1 ? 
ATOM   3908 H HH     B TYR A 1 242 ? 0.439   -6.419  3.152   0.37 21.184 ? 1250 TYR A HH     1 ? 
ATOM   3909 N N      . VAL A 1 243 ? 9.331   -8.156  3.876   1    21.233 ? 1251 VAL A N      1 ? 
ATOM   3910 C CA     . VAL A 1 243 ? 10.762  -8.403  3.747   1    20.842 ? 1251 VAL A CA     1 ? 
ATOM   3911 C C      . VAL A 1 243 ? 11.155  -8.521  2.268   1    19.537 ? 1251 VAL A C      1 ? 
ATOM   3912 O O      . VAL A 1 243 ? 12.214  -8.038  1.901   1    19.449 ? 1251 VAL A O      1 ? 
ATOM   3913 C CB     . VAL A 1 243 ? 11.175  -9.614  4.609   1    19.423 ? 1251 VAL A CB     1 ? 
ATOM   3914 C CG1    . VAL A 1 243 ? 10.856  -10.974 4.033   1    18.253 ? 1251 VAL A CG1    1 ? 
ATOM   3915 C CG2    . VAL A 1 243 ? 12.654  -9.537  4.969   1    21.839 ? 1251 VAL A CG2    1 ? 
ATOM   3916 H H      . VAL A 1 243 ? 8.758   -8.888  4.327   1    22.057 ? 1251 VAL A H      1 ? 
ATOM   3917 H HA     . VAL A 1 243 ? 11.278  -7.529  4.151   1    20.409 ? 1251 VAL A HA     1 c 
ATOM   3918 H HB     . VAL A 1 243 ? 10.619  -9.532  5.545   1    19.865 ? 1251 VAL A HB     1 c 
ATOM   3919 H HG11   . VAL A 1 243 ? 11.406  -11.115 3.1     1    18.591 ? 1251 VAL A HG11   1 c 
ATOM   3920 H HG12   . VAL A 1 243 ? 11.146  -11.749 4.745   1    18.587 ? 1251 VAL A HG12   1 c 
ATOM   3921 H HG13   . VAL A 1 243 ? 9.784   -11.045 3.836   1    18.631 ? 1251 VAL A HG13   1 c 
ATOM   3922 H HG21   . VAL A 1 243 ? 12.926  -10.403 5.577   1    21.138 ? 1251 VAL A HG21   1 c 
ATOM   3923 H HG22   . VAL A 1 243 ? 13.252  -9.532  4.056   1    21.138 ? 1251 VAL A HG22   1 c 
ATOM   3924 H HG23   . VAL A 1 243 ? 12.845  -8.623  5.534   1    21.131 ? 1251 VAL A HG23   1 c 
ATOM   3925 N N      . GLN A 1 244 ? 10.265  -9.067  1.423   1    21.052 ? 1252 GLN A N      1 ? 
ATOM   3926 C CA     . GLN A 1 244 ? 10.538  -9.166  -0.016  1    22.022 ? 1252 GLN A CA     1 ? 
ATOM   3927 C C      . GLN A 1 244 ? 10.732  -7.76   -0.573  1    22.147 ? 1252 GLN A C      1 ? 
ATOM   3928 O O      . GLN A 1 244 ? 11.543  -7.555  -1.462  1    20.72  ? 1252 GLN A O      1 ? 
ATOM   3929 C CB     . GLN A 1 244 ? 9.507   -9.94   -0.861  1    23.047 ? 1252 GLN A CB     1 ? 
ATOM   3930 C CG     . GLN A 1 244 ? 8.06    -9.437  -0.785  1    22.909 ? 1252 GLN A CG     1 ? 
ATOM   3931 C CD     . GLN A 1 244 ? 7.261   -10.053 0.347   1    24.98  ? 1252 GLN A CD     1 ? 
ATOM   3932 O OE1    . GLN A 1 244 ? 7.818   -10.405 1.397   1    22.456 ? 1252 GLN A OE1    1 ? 
ATOM   3933 N NE2    . GLN A 1 244 ? 5.954   -10.248 0.131   1    24.141 ? 1252 GLN A NE2    1 ? 
ATOM   3934 H H      . GLN A 1 244 ? 9.399   -9.498  1.8     1    20.466 ? 1252 GLN A H      1 ? 
ATOM   3935 H HA     . GLN A 1 244 ? 11.487  -9.694  -0.128  1    22.036 ? 1252 GLN A HA     1 c 
ATOM   3936 H HB2    . GLN A 1 244 ? 9.831   -9.911  -1.902  1    22.756 ? 1252 GLN A HB2    1 c 
ATOM   3937 H HB3    . GLN A 1 244 ? 9.526   -10.984 -0.543  1    22.758 ? 1252 GLN A HB3    1 c 
ATOM   3938 H HG2    . GLN A 1 244 ? 8.061   -8.353  -0.66   1    23.377 ? 1252 GLN A HG2    1 c 
ATOM   3939 H HG3    . GLN A 1 244 ? 7.554   -9.66   -1.726  1    23.364 ? 1252 GLN A HG3    1 c 
ATOM   3940 H HE21   . GLN A 1 244 ? 5.521   -10.054 -0.765  1    25.422 ? 1252 GLN A HE21   1 ? 
ATOM   3941 H HE22   . GLN A 1 244 ? 5.39    -10.614 0.866   1    24.443 ? 1252 GLN A HE22   1 ? 
ATOM   3942 N N      . ASP A 1 245 ? 9.972   -6.777  -0.075  1    24.408 ? 1253 ASP A N      1 ? 
ATOM   3943 C CA     . ASP A 1 245 ? 10.074  -5.439  -0.634  1    25.297 ? 1253 ASP A CA     1 ? 
ATOM   3944 C C      . ASP A 1 245 ? 11.458  -4.868  -0.339  1    25.898 ? 1253 ASP A C      1 ? 
ATOM   3945 O O      . ASP A 1 245 ? 11.99   -4.099  -1.139  1    23.857 ? 1253 ASP A O      1 ? 
ATOM   3946 C CB     . ASP A 1 245 ? 8.868   -4.599  -0.263  1    29.916 ? 1253 ASP A CB     1 ? 
ATOM   3947 C CG     . ASP A 1 245 ? 7.544   -5.308  -0.499  1    33.537 ? 1253 ASP A CG     1 ? 
ATOM   3948 O OD1    . ASP A 1 245 ? 7.335   -5.817  -1.618  1    35.206 ? 1253 ASP A OD1    1 ? 
ATOM   3949 O OD2    . ASP A 1 245 ? 6.75    -5.368  0.457   1    38.362 ? 1253 ASP A OD2    1 ? 
ATOM   3950 H H      . ASP A 1 245 ? 9.276   -6.967  0.669   1    24.763 ? 1253 ASP A H      1 ? 
ATOM   3951 H HA     . ASP A 1 245 ? 9.999   -5.541  -1.719  1    25.997 ? 1253 ASP A HA     1 c 
ATOM   3952 H HB2    . ASP A 1 245 ? 8.927   -4.375  0.801   1    29.448 ? 1253 ASP A HB2    1 c 
ATOM   3953 H HB3    . ASP A 1 245 ? 8.876   -3.66   -0.82   1    29.496 ? 1253 ASP A HB3    1 c 
ATOM   3954 N N      . LYS A 1 246 ? 12.033  -5.274  0.802   1    22.461 ? 1254 LYS A N      1 ? 
ATOM   3955 C CA     . LYS A 1 246 ? 13.325  -4.803  1.246   1    22.107 ? 1254 LYS A CA     1 ? 
ATOM   3956 C C      . LYS A 1 246 ? 14.422  -5.442  0.383   1    21.149 ? 1254 LYS A C      1 ? 
ATOM   3957 O O      . LYS A 1 246 ? 15.397  -4.764  0.025   1    21.747 ? 1254 LYS A O      1 ? 
ATOM   3958 C CB     . LYS A 1 246 ? 13.479  -5      2.762   1    23.306 ? 1254 LYS A CB     1 ? 
ATOM   3959 C CG     . LYS A 1 246 ? 13.093  -3.743  3.58    1    22.901 ? 1254 LYS A CG     1 ? 
ATOM   3960 C CD     . LYS A 1 246 ? 14.11   -2.604  3.483   1    22.141 ? 1254 LYS A CD     1 ? 
ATOM   3961 C CE     . LYS A 1 246 ? 13.456  -1.397  4.05    1    23.847 ? 1254 LYS A CE     1 ? 
ATOM   3962 N NZ     . LYS A 1 246 ? 14.223  -0.231  3.698   1    22.54  ? 1254 LYS A NZ     1 ? 
ATOM   3963 H H      . LYS A 1 246 ? 11.539  -5.973  1.384   1    25.031 ? 1254 LYS A H      1 ? 
ATOM   3964 H HA     . LYS A 1 246 ? 13.357  -3.726  1.065   1    22.214 ? 1254 LYS A HA     1 c 
ATOM   3965 H HB2    . LYS A 1 246 ? 12.85   -5.834  3.082   1    22.932 ? 1254 LYS A HB2    1 c 
ATOM   3966 H HB3    . LYS A 1 246 ? 14.517  -5.258  2.985   1    22.872 ? 1254 LYS A HB3    1 c 
ATOM   3967 H HG2    . LYS A 1 246 ? 12.123  -3.385  3.228   1    22.824 ? 1254 LYS A HG2    1 c 
ATOM   3968 H HG3    . LYS A 1 246 ? 12.981  -4.031  4.627   1    22.821 ? 1254 LYS A HG3    1 c 
ATOM   3969 H HD2    . LYS A 1 246 ? 15.005  -2.845  4.059   1    22.634 ? 1254 LYS A HD2    1 c 
ATOM   3970 H HD3    . LYS A 1 246 ? 14.38   -2.423  2.44    1    22.663 ? 1254 LYS A HD3    1 c 
ATOM   3971 H HE2    . LYS A 1 246 ? 12.439  -1.301  3.664   1    23.475 ? 1254 LYS A HE2    1 c 
ATOM   3972 H HE3    . LYS A 1 246 ? 13.427  -1.492  5.135   1    23.509 ? 1254 LYS A HE3    1 c 
ATOM   3973 H HZ1    . LYS A 1 246 ? 14.426  -0.273  2.711   1    22.978 ? 1254 LYS A HZ1    1 ? 
ATOM   3974 H HZ2    . LYS A 1 246 ? 13.754  0.652   3.915   1    23.013 ? 1254 LYS A HZ2    1 ? 
ATOM   3975 H HZ3    . LYS A 1 246 ? 15.087  -0.284  4.206   1    23.61  ? 1254 LYS A HZ3    1 ? 
ATOM   3976 N N      . ILE A 1 247 ? 14.275  -6.728  0.061   1    19.015 ? 1255 ILE A N      1 ? 
ATOM   3977 C CA     . ILE A 1 247 ? 15.175  -7.405  -0.864  1    20.123 ? 1255 ILE A CA     1 ? 
ATOM   3978 C C      . ILE A 1 247 ? 15.184  -6.684  -2.209  1    20.965 ? 1255 ILE A C      1 ? 
ATOM   3979 O O      . ILE A 1 247 ? 16.24   -6.432  -2.793  1    17.475 ? 1255 ILE A O      1 ? 
ATOM   3980 C CB     . ILE A 1 247 ? 14.771  -8.879  -1.035  1    20.174 ? 1255 ILE A CB     1 ? 
ATOM   3981 C CG1    . ILE A 1 247 ? 14.925  -9.643  0.301   1    22.668 ? 1255 ILE A CG1    1 ? 
ATOM   3982 C CG2    . ILE A 1 247 ? 15.576  -9.544  -2.151  1    21.393 ? 1255 ILE A CG2    1 ? 
ATOM   3983 C CD1    . ILE A 1 247 ? 14.411  -11.065 0.226   1    19.116 ? 1255 ILE A CD1    1 ? 
ATOM   3984 H H      . ILE A 1 247 ? 13.494  -7.266  0.48    1    19.705 ? 1255 ILE A H      1 ? 
ATOM   3985 H HA     . ILE A 1 247 ? 16.183  -7.371  -0.447  1    20.064 ? 1255 ILE A HA     1 c 
ATOM   3986 H HB     . ILE A 1 247 ? 13.717  -8.907  -1.316  1    20.807 ? 1255 ILE A HB     1 c 
ATOM   3987 H HG12   . ILE A 1 247 ? 15.981  -9.661  0.579   1    21.285 ? 1255 ILE A HG12   1 c 
ATOM   3988 H HG13   . ILE A 1 247 ? 14.379  -9.109  1.082   1    21.254 ? 1255 ILE A HG13   1 c 
ATOM   3989 H HG21   . ILE A 1 247 ? 16.643  -9.458  -1.934  1    21.037 ? 1255 ILE A HG21   1 c 
ATOM   3990 H HG22   . ILE A 1 247 ? 15.306  -10.599 -2.222  1    21.022 ? 1255 ILE A HG22   1 c 
ATOM   3991 H HG23   . ILE A 1 247 ? 15.361  -9.054  -3.103  1    21.018 ? 1255 ILE A HG23   1 c 
ATOM   3992 H HD11   . ILE A 1 247 ? 13.379  -11.064 -0.131  1    20.033 ? 1255 ILE A HD11   1 c 
ATOM   3993 H HD12   . ILE A 1 247 ? 15.031  -11.646 -0.46   1    20.045 ? 1255 ILE A HD12   1 c 
ATOM   3994 H HD13   . ILE A 1 247 ? 14.45   -11.519 1.218   1    19.978 ? 1255 ILE A HD13   1 c 
ATOM   3995 N N      . GLU A 1 248 ? 13.997  -6.291  -2.686  1    22.111 ? 1256 GLU A N      1 ? 
ATOM   3996 C CA     . GLU A 1 248 ? 13.888  -5.642  -3.979  1    21.646 ? 1256 GLU A CA     1 ? 
ATOM   3997 C C      . GLU A 1 248 ? 14.595  -4.286  -4.001  1    20.813 ? 1256 GLU A C      1 ? 
ATOM   3998 O O      . GLU A 1 248 ? 15.121  -3.889  -5.046  1    20.625 ? 1256 GLU A O      1 ? 
ATOM   3999 C CB     . GLU A 1 248 ? 12.41   -5.474  -4.34   1    25.236 ? 1256 GLU A CB     1 ? 
ATOM   4000 C CG     . GLU A 1 248 ? 12.193  -4.9    -5.74   1    26.942 ? 1256 GLU A CG     1 ? 
ATOM   4001 C CD     . GLU A 1 248 ? 10.776  -4.5    -6.15   1    31.954 ? 1256 GLU A CD     1 ? 
ATOM   4002 O OE1    . GLU A 1 248 ? 9.768   -4.923  -5.553  1    25.9   ? 1256 GLU A OE1    1 ? 
ATOM   4003 O OE2    . GLU A 1 248 ? 10.711  -3.716  -7.144  1    35.16  ? 1256 GLU A OE2    1 ? 
ATOM   4004 H H      . GLU A 1 248 ? 13.147  -6.515  -2.137  1    21.652 ? 1256 GLU A H      1 ? 
ATOM   4005 H HA     . GLU A 1 248 ? 14.356  -6.288  -4.725  1    22.177 ? 1256 GLU A HA     1 c 
ATOM   4006 H HB2    . GLU A 1 248 ? 11.92   -6.447  -4.275  1    24.753 ? 1256 GLU A HB2    1 c 
ATOM   4007 H HB3    . GLU A 1 248 ? 11.941  -4.816  -3.607  1    24.746 ? 1256 GLU A HB3    1 c 
ATOM   4008 H HG2    . GLU A 1 248 ? 12.826  -4.019  -5.851  1    27.629 ? 1256 GLU A HG2    1 c 
ATOM   4009 H HG3    . GLU A 1 248 ? 12.554  -5.631  -6.466  1    27.587 ? 1256 GLU A HG3    1 c 
ATOM   4010 N N      . GLU A 1 249 ? 14.616  -3.575  -2.872  1    21.132 ? 1257 GLU A N      1 ? 
ATOM   4011 C CA     . GLU A 1 249 ? 15.361  -2.335  -2.777  1    22.214 ? 1257 GLU A CA     1 ? 
ATOM   4012 C C      . GLU A 1 249 ? 16.844  -2.535  -3.081  1    22.242 ? 1257 GLU A C      1 ? 
ATOM   4013 O O      . GLU A 1 249 ? 17.528  -1.581  -3.483  1    19.089 ? 1257 GLU A O      1 ? 
ATOM   4014 C CB     . GLU A 1 249 ? 15.214  -1.787  -1.367  1    25.255 ? 1257 GLU A CB     1 ? 
ATOM   4015 C CG     . GLU A 1 249 ? 13.866  -1.139  -1.085  1    27.129 ? 1257 GLU A CG     1 ? 
ATOM   4016 C CD     . GLU A 1 249 ? 13.912  -0.432  0.261   1    31.069 ? 1257 GLU A CD     1 ? 
ATOM   4017 O OE1    . GLU A 1 249 ? 15.033  -0.253  0.787   1    30.289 ? 1257 GLU A OE1    1 ? 
ATOM   4018 O OE2    . GLU A 1 249 ? 12.842  -0.079  0.801   1    36.227 ? 1257 GLU A OE2    1 ? 
ATOM   4019 H H      . GLU A 1 249 ? 14.152  -3.909  -2.017  1    21.742 ? 1257 GLU A H      1 ? 
ATOM   4020 H HA     . GLU A 1 249 ? 14.943  -1.622  -3.491  1    22.515 ? 1257 GLU A HA     1 c 
ATOM   4021 H HB2    . GLU A 1 249 ? 15.369  -2.599  -0.656  1    24.92  ? 1257 GLU A HB2    1 c 
ATOM   4022 H HB3    . GLU A 1 249 ? 16.002  -1.049  -1.202  1    24.956 ? 1257 GLU A HB3    1 c 
ATOM   4023 H HG2    . GLU A 1 249 ? 13.632  -0.413  -1.867  1    27.502 ? 1257 GLU A HG2    1 c 
ATOM   4024 H HG3    . GLU A 1 249 ? 13.086  -1.901  -1.064  1    27.452 ? 1257 GLU A HG3    1 c 
ATOM   4025 N N      . TYR A 1 250 ? 17.356  -3.761  -2.892  1    21.647 ? 1258 TYR A N      1 ? 
ATOM   4026 C CA     . TYR A 1 250 ? 18.747  -4.086  -3.168  1    20.044 ? 1258 TYR A CA     1 ? 
ATOM   4027 C C      . TYR A 1 250 ? 18.857  -5.142  -4.271  1    19.834 ? 1258 TYR A C      1 ? 
ATOM   4028 O O      . TYR A 1 250 ? 19.786  -5.947  -4.263  1    17.833 ? 1258 TYR A O      1 ? 
ATOM   4029 C CB     . TYR A 1 250 ? 19.457  -4.566  -1.906  1    18.86  ? 1258 TYR A CB     1 ? 
ATOM   4030 C CG     . TYR A 1 250 ? 19.443  -3.571  -0.767  1    18.609 ? 1258 TYR A CG     1 ? 
ATOM   4031 C CD1    . TYR A 1 250 ? 20.403  -2.586  -0.671  1    19.599 ? 1258 TYR A CD1    1 ? 
ATOM   4032 C CD2    . TYR A 1 250 ? 18.468  -3.638  0.217   1    20.227 ? 1258 TYR A CD2    1 ? 
ATOM   4033 C CE1    . TYR A 1 250 ? 20.405  -1.683  0.381   1    19.714 ? 1258 TYR A CE1    1 ? 
ATOM   4034 C CE2    . TYR A 1 250 ? 18.463  -2.761  1.296   1    21.426 ? 1258 TYR A CE2    1 ? 
ATOM   4035 C CZ     . TYR A 1 250 ? 19.433  -1.776  1.374   1    20.774 ? 1258 TYR A CZ     1 ? 
ATOM   4036 O OH     . TYR A 1 250 ? 19.452  -0.896  2.429   1    22.343 ? 1258 TYR A OH     1 ? 
ATOM   4037 H H      . TYR A 1 250 ? 16.733  -4.518  -2.561  1    21.136 ? 1258 TYR A H      1 ? 
ATOM   4038 H HA     . TYR A 1 250 ? 19.247  -3.18   -3.514  1    20.085 ? 1258 TYR A HA     1 c 
ATOM   4039 H HB2    . TYR A 1 250 ? 18.982  -5.491  -1.573  1    19.055 ? 1258 TYR A HB2    1 c 
ATOM   4040 H HB3    . TYR A 1 250 ? 20.494  -4.796  -2.159  1    19.049 ? 1258 TYR A HB3    1 c 
ATOM   4041 H HD1    . TYR A 1 250 ? 21.169  -2.514  -1.434  1    19.476 ? 1258 TYR A HD1    1 c 
ATOM   4042 H HD2    . TYR A 1 250 ? 17.719  -4.419  0.168   1    20.125 ? 1258 TYR A HD2    1 c 
ATOM   4043 H HE1    . TYR A 1 250 ? 21.175  -0.92   0.444   1    19.928 ? 1258 TYR A HE1    1 c 
ATOM   4044 H HE2    . TYR A 1 250 ? 17.698  -2.835  2.061   1    20.99  ? 1258 TYR A HE2    1 c 
ATOM   4045 H HH     . TYR A 1 250 ? 19.045  -1.233  3.218   1    20.373 ? 1258 TYR A HH     1 ? 
ATOM   4046 N N      . SER A 1 251 ? 17.926  -5.113  -5.242  1    20.948 ? 1259 SER A N      1 ? 
ATOM   4047 C CA     A SER A 1 251 ? 17.807  -6.149  -6.276  0.5  20.232 ? 1259 SER A CA     1 ? 
ATOM   4048 C CA     B SER A 1 251 ? 17.815  -6.144  -6.275  0.5  20.194 ? 1259 SER A CA     1 ? 
ATOM   4049 C C      . SER A 1 251 ? 19.15   -6.448  -6.929  1    19.231 ? 1259 SER A C      1 ? 
ATOM   4050 O O      . SER A 1 251 ? 19.573  -7.601  -7.068  1    17.519 ? 1259 SER A O      1 ? 
ATOM   4051 C CB     A SER A 1 251 ? 16.731  -5.866  -7.331  0.5  20.747 ? 1259 SER A CB     1 ? 
ATOM   4052 C CB     B SER A 1 251 ? 16.829  -5.765  -7.375  0.5  20.698 ? 1259 SER A CB     1 ? 
ATOM   4053 O OG     A SER A 1 251 ? 16.494  -4.487  -7.557  0.5  21.533 ? 1259 SER A OG     1 ? 
ATOM   4054 O OG     B SER A 1 251 ? 15.671  -5.115  -6.872  0.5  21.246 ? 1259 SER A OG     1 ? 
ATOM   4055 H H      . SER A 1 251 ? 17.167  -4.416  -5.162  1    20.805 ? 1259 SER A H      1 ? 
ATOM   4056 H HA     . SER A 1 251 ? 17.481  -7.061  -5.778  1    20.296 ? 1259 SER A HA     1 c 
ATOM   4057 H HB2    A SER A 1 251 ? 17.031  -6.331  -8.272  0.5  20.806 ? 1259 SER A HB2    1 c 
ATOM   4058 H HB2    B SER A 1 251 ? 17.327  -5.106  -8.089  0.5  20.704 ? 1259 SER A HB2    1 c 
ATOM   4059 H HB3    A SER A 1 251 ? 15.798  -6.338  -7.016  0.5  20.814 ? 1259 SER A HB3    1 c 
ATOM   4060 H HB3    B SER A 1 251 ? 16.528  -6.667  -7.908  0.5  20.706 ? 1259 SER A HB3    1 c 
ATOM   4061 H HG     . SER A 1 251 ? 15.517  -4.395  -7.519  1    21.097 ? 1259 SER A HG     1 ? 
ATOM   4062 N N      . ASP A 1 252 ? 19.795  -5.396  -7.424  1    20.568 ? 1260 ASP A N      1 ? 
ATOM   4063 C CA     . ASP A 1 252 ? 21.034  -5.564  -8.174  1    19.436 ? 1260 ASP A CA     1 ? 
ATOM   4064 C C      . ASP A 1 252 ? 22.149  -6.114  -7.295  1    18.983 ? 1260 ASP A C      1 ? 
ATOM   4065 O O      . ASP A 1 252 ? 22.834  -7.072  -7.668  1    20.485 ? 1260 ASP A O      1 ? 
ATOM   4066 C CB     . ASP A 1 252 ? 21.432  -4.262  -8.854  1    23.002 ? 1260 ASP A CB     1 ? 
ATOM   4067 C CG     . ASP A 1 252 ? 22.471  -4.451  -9.943  1    25.852 ? 1260 ASP A CG     1 ? 
ATOM   4068 O OD1    . ASP A 1 252 ? 22.473  -5.508  -10.611 1    27.846 ? 1260 ASP A OD1    1 ? 
ATOM   4069 O OD2    . ASP A 1 252 ? 23.252  -3.499  -10.188 1    31.757 ? 1260 ASP A OD2    1 ? 
ATOM   4070 H H      . ASP A 1 252 ? 19.441  -4.452  -7.18   1    19.166 ? 1260 ASP A H      1 ? 
ATOM   4071 H HA     . ASP A 1 252 ? 20.843  -6.29   -8.966  1    20.22  ? 1260 ASP A HA     1 c 
ATOM   4072 H HB2    . ASP A 1 252 ? 20.545  -3.803  -9.297  1    22.75  ? 1260 ASP A HB2    1 c 
ATOM   4073 H HB3    . ASP A 1 252 ? 21.834  -3.576  -8.106  1    22.75  ? 1260 ASP A HB3    1 c 
ATOM   4074 N N      . GLU A 1 253 ? 22.343  -5.516  -6.127  1    18.867 ? 1261 GLU A N      1 ? 
ATOM   4075 C CA     . GLU A 1 253 ? 23.378  -6.013  -5.231  1    17.995 ? 1261 GLU A CA     1 ? 
ATOM   4076 C C      . GLU A 1 253 ? 23.143  -7.48   -4.882  1    16.195 ? 1261 GLU A C      1 ? 
ATOM   4077 O O      . GLU A 1 253 ? 24.086  -8.278  -4.869  1    17.361 ? 1261 GLU A O      1 ? 
ATOM   4078 C CB     . GLU A 1 253 ? 23.482  -5.182  -3.954  1    19.701 ? 1261 GLU A CB     1 ? 
ATOM   4079 C CG     . GLU A 1 253 ? 23.804  -3.72   -4.157  1    20.441 ? 1261 GLU A CG     1 ? 
ATOM   4080 C CD     . GLU A 1 253 ? 24.236  -3.069  -2.871  1    23.816 ? 1261 GLU A CD     1 ? 
ATOM   4081 O OE1    . GLU A 1 253 ? 25.383  -3.267  -2.378  1    27.7   ? 1261 GLU A OE1    1 ? 
ATOM   4082 O OE2    . GLU A 1 253 ? 23.368  -2.399  -2.301  1    26.718 ? 1261 GLU A OE2    1 ? 
ATOM   4083 H H      . GLU A 1 253 ? 21.707  -4.753  -5.809  1    17.742 ? 1261 GLU A H      1 ? 
ATOM   4084 H HA     . GLU A 1 253 ? 24.333  -5.939  -5.754  1    18.151 ? 1261 GLU A HA     1 c 
ATOM   4085 H HB2    . GLU A 1 253 ? 22.533  -5.252  -3.417  1    19.474 ? 1261 GLU A HB2    1 c 
ATOM   4086 H HB3    . GLU A 1 253 ? 24.254  -5.619  -3.317  1    19.474 ? 1261 GLU A HB3    1 c 
ATOM   4087 H HG2    . GLU A 1 253 ? 24.606  -3.623  -4.891  1    20.973 ? 1261 GLU A HG2    1 c 
ATOM   4088 H HG3    . GLU A 1 253 ? 22.922  -3.202  -4.54   1    20.973 ? 1261 GLU A HG3    1 c 
ATOM   4089 N N      . ILE A 1 254 ? 21.895  -7.843  -4.576  1    15.94  ? 1262 ILE A N      1 ? 
ATOM   4090 C CA     . ILE A 1 254 ? 21.601  -9.203  -4.144  1    16.954 ? 1262 ILE A CA     1 ? 
ATOM   4091 C C      . ILE A 1 254 ? 21.825  -10.196 -5.285  1    16.234 ? 1262 ILE A C      1 ? 
ATOM   4092 O O      . ILE A 1 254 ? 22.444  -11.248 -5.089  1    14.057 ? 1262 ILE A O      1 ? 
ATOM   4093 C CB     . ILE A 1 254 ? 20.175  -9.289  -3.561  1    18.051 ? 1262 ILE A CB     1 ? 
ATOM   4094 C CG1    . ILE A 1 254 ? 20.068  -8.523  -2.234  1    19.754 ? 1262 ILE A CG1    1 ? 
ATOM   4095 C CG2    . ILE A 1 254 ? 19.725  -10.737 -3.411  1    17.004 ? 1262 ILE A CG2    1 ? 
ATOM   4096 C CD1    . ILE A 1 254 ? 20.798  -9.169  -1.07   1    24.211 ? 1262 ILE A CD1    1 ? 
ATOM   4097 H H      . ILE A 1 254 ? 21.121  -7.154  -4.609  1    15.616 ? 1262 ILE A H      1 ? 
ATOM   4098 H HA     . ILE A 1 254 ? 22.301  -9.453  -3.344  1    16.886 ? 1262 ILE A HA     1 c 
ATOM   4099 H HB     . ILE A 1 254 ? 19.502  -8.806  -4.272  1    17.946 ? 1262 ILE A HB     1 c 
ATOM   4100 H HG12   . ILE A 1 254 ? 20.468  -7.517  -2.379  1    20.22  ? 1262 ILE A HG12   1 c 
ATOM   4101 H HG13   . ILE A 1 254 ? 19.012  -8.425  -1.972  1    20.252 ? 1262 ILE A HG13   1 c 
ATOM   4102 H HG21   . ILE A 1 254 ? 18.776  -10.77  -2.871  1    17.284 ? 1262 ILE A HG21   1 c 
ATOM   4103 H HG22   . ILE A 1 254 ? 19.593  -11.187 -4.398  1    17.279 ? 1262 ILE A HG22   1 c 
ATOM   4104 H HG23   . ILE A 1 254 ? 20.476  -11.299 -2.853  1    17.277 ? 1262 ILE A HG23   1 c 
ATOM   4105 H HD11   . ILE A 1 254 ? 20.382  -10.16  -0.877  1    22.801 ? 1262 ILE A HD11   1 c 
ATOM   4106 H HD12   . ILE A 1 254 ? 21.86   -9.263  -1.307  1    22.782 ? 1262 ILE A HD12   1 c 
ATOM   4107 H HD13   . ILE A 1 254 ? 20.68   -8.549  -0.179  1    22.756 ? 1262 ILE A HD13   1 c 
ATOM   4108 N N      . PHE A 1 255 ? 21.331  -9.885  -6.487  1    15.378 ? 1263 PHE A N      1 ? 
ATOM   4109 C CA     . PHE A 1 255 ? 21.502  -10.823 -7.584  1    14.086 ? 1263 PHE A CA     1 ? 
ATOM   4110 C C      . PHE A 1 255 ? 22.984  -10.989 -7.924  1    13.477 ? 1263 PHE A C      1 ? 
ATOM   4111 O O      . PHE A 1 255 ? 23.442  -12.097 -8.219  1    13.317 ? 1263 PHE A O      1 ? 
ATOM   4112 C CB     . PHE A 1 255 ? 20.672  -10.409 -8.808  1    15.406 ? 1263 PHE A CB     1 ? 
ATOM   4113 C CG     . PHE A 1 255 ? 19.271  -10.981 -8.792  1    16.303 ? 1263 PHE A CG     1 ? 
ATOM   4114 C CD1    . PHE A 1 255 ? 18.468  -10.873 -7.665  1    16.941 ? 1263 PHE A CD1    1 ? 
ATOM   4115 C CD2    . PHE A 1 255 ? 18.768  -11.65  -9.899  1    16.605 ? 1263 PHE A CD2    1 ? 
ATOM   4116 C CE1    . PHE A 1 255 ? 17.191  -11.412 -7.653  1    17.55  ? 1263 PHE A CE1    1 ? 
ATOM   4117 C CE2    . PHE A 1 255 ? 17.484  -12.187 -9.878  1    15.406 ? 1263 PHE A CE2    1 ? 
ATOM   4118 C CZ     . PHE A 1 255 ? 16.693  -12.059 -8.767  1    15.619 ? 1263 PHE A CZ     1 ? 
ATOM   4119 H H      . PHE A 1 255 ? 20.881  -8.974  -6.643  1    16.826 ? 1263 PHE A H      1 ? 
ATOM   4120 H HA     . PHE A 1 255 ? 21.129  -11.792 -7.246  1    14.436 ? 1263 PHE A HA     1 c 
ATOM   4121 H HB2    . PHE A 1 255 ? 20.612  -9.319  -8.839  1    15.298 ? 1263 PHE A HB2    1 c 
ATOM   4122 H HB3    . PHE A 1 255 ? 21.185  -10.749 -9.71   1    15.298 ? 1263 PHE A HB3    1 c 
ATOM   4123 H HD1    . PHE A 1 255 ? 18.843  -10.359 -6.786  1    16.892 ? 1263 PHE A HD1    1 c 
ATOM   4124 H HD2    . PHE A 1 255 ? 19.38   -11.75  -10.789 1    16.267 ? 1263 PHE A HD2    1 c 
ATOM   4125 H HE1    . PHE A 1 255 ? 16.573  -11.309 -6.767  1    16.95  ? 1263 PHE A HE1    1 c 
ATOM   4126 H HE2    . PHE A 1 255 ? 17.102  -12.697 -10.756 1    15.729 ? 1263 PHE A HE2    1 c 
ATOM   4127 H HZ     . PHE A 1 255 ? 15.693  -12.482 -8.754  1    15.987 ? 1263 PHE A HZ     1 c 
ATOM   4128 N N      . LYS A 1 256 ? 23.756  -9.888  -7.869  1    15.646 ? 1264 LYS A N      1 ? 
ATOM   4129 C CA     . LYS A 1 256 ? 25.19   -9.968  -8.085  1    15.977 ? 1264 LYS A CA     1 ? 
ATOM   4130 C C      . LYS A 1 256 ? 25.842  -10.896 -7.038  1    15.931 ? 1264 LYS A C      1 ? 
ATOM   4131 O O      . LYS A 1 256 ? 26.716  -11.71  -7.356  1    15.027 ? 1264 LYS A O      1 ? 
ATOM   4132 C CB     . LYS A 1 256 ? 25.779  -8.557  -8.114  1    19.869 ? 1264 LYS A CB     1 ? 
ATOM   4133 C CG     . LYS A 1 256 ? 25.654  -7.795  -9.465  1    24.223 ? 1264 LYS A CG     1 ? 
ATOM   4134 C CD     . LYS A 1 256 ? 26.255  -6.386  -9.436  1    25.461 ? 1264 LYS A CD     1 ? 
ATOM   4135 C CE     . LYS A 1 256 ? 26.377  -5.707  -10.757 1    28.685 ? 1264 LYS A CE     1 ? 
ATOM   4136 N NZ     . LYS A 1 256 ? 25.102  -5.648  -11.499 1    30.359 ? 1264 LYS A NZ     1 ? 
ATOM   4137 H H      . LYS A 1 256 ? 23.351  -8.982  -7.594  1    14.525 ? 1264 LYS A H      1 ? 
ATOM   4138 H HA     . LYS A 1 256 ? 25.352  -10.41  -9.07   1    16.597 ? 1264 LYS A HA     1 c 
ATOM   4139 H HB2    . LYS A 1 256 ? 25.289  -7.962  -7.34   1    19.766 ? 1264 LYS A HB2    1 c 
ATOM   4140 H HB3    . LYS A 1 256 ? 26.839  -8.621  -7.856  1    19.766 ? 1264 LYS A HB3    1 c 
ATOM   4141 H HG2    . LYS A 1 256 ? 26.153  -8.379  -10.241 1    23.461 ? 1264 LYS A HG2    1 c 
ATOM   4142 H HG3    . LYS A 1 256 ? 24.596  -7.725  -9.727  1    23.461 ? 1264 LYS A HG3    1 c 
ATOM   4143 H HD2    . LYS A 1 256 ? 25.64   -5.765  -8.782  1    25.876 ? 1264 LYS A HD2    1 c 
ATOM   4144 H HD3    . LYS A 1 256 ? 27.246  -6.446  -8.983  1    25.912 ? 1264 LYS A HD3    1 c 
ATOM   4145 H HE2    . LYS A 1 256 ? 26.742  -4.69   -10.607 1    28.299 ? 1264 LYS A HE2    1 c 
ATOM   4146 H HE3    . LYS A 1 256 ? 27.111  -6.24   -11.365 1    28.298 ? 1264 LYS A HE3    1 c 
ATOM   4147 H HZ1    . LYS A 1 256 ? 24.457  -5.061  -10.985 1    30.129 ? 1264 LYS A HZ1    1 ? 
ATOM   4148 H HZ2    . LYS A 1 256 ? 25.269  -5.223  -12.409 1    29.64  ? 1264 LYS A HZ2    1 ? 
ATOM   4149 H HZ3    . LYS A 1 256 ? 24.654  -6.561  -11.664 1    31.338 ? 1264 LYS A HZ3    1 ? 
ATOM   4150 N N      . LEU A 1 257 ? 25.444  -10.747 -5.765  1    13.276 ? 1265 LEU A N      1 ? 
ATOM   4151 C CA     . LEU A 1 257 ? 26.016  -11.588 -4.73   1    14.696 ? 1265 LEU A CA     1 ? 
ATOM   4152 C C      . LEU A 1 257 ? 25.669  -13.058 -4.96   1    14.995 ? 1265 LEU A C      1 ? 
ATOM   4153 O O      . LEU A 1 257 ? 26.521  -13.94  -4.781  1    14.587 ? 1265 LEU A O      1 ? 
ATOM   4154 C CB     . LEU A 1 257 ? 25.537  -11.139 -3.354  1    14.502 ? 1265 LEU A CB     1 ? 
ATOM   4155 C CG     . LEU A 1 257 ? 26.108  -9.815  -2.848  1    15.081 ? 1265 LEU A CG     1 ? 
ATOM   4156 C CD1    . LEU A 1 257 ? 25.382  -9.381  -1.583  1    15.06  ? 1265 LEU A CD1    1 ? 
ATOM   4157 C CD2    . LEU A 1 257 ? 27.591  -9.926  -2.579  1    15.191 ? 1265 LEU A CD2    1 ? 
ATOM   4158 H H      . LEU A 1 257 ? 24.724  -10.05  -5.503  1    14.078 ? 1265 LEU A H      1 ? 
ATOM   4159 H HA     . LEU A 1 257 ? 27.101  -11.486 -4.777  1    14.443 ? 1265 LEU A HA     1 c 
ATOM   4160 H HB2    . LEU A 1 257 ? 24.448  -11.055 -3.383  1    14.669 ? 1265 LEU A HB2    1 c 
ATOM   4161 H HB3    . LEU A 1 257 ? 25.789  -11.92  -2.634  1    14.669 ? 1265 LEU A HB3    1 c 
ATOM   4162 H HG     . LEU A 1 257 ? 25.954  -9.055  -3.615  1    15.007 ? 1265 LEU A HG     1 c 
ATOM   4163 H HD11   . LEU A 1 257 ? 25.797  -8.435  -1.23   1    15.062 ? 1265 LEU A HD11   1 c 
ATOM   4164 H HD12   . LEU A 1 257 ? 24.319  -9.253  -1.798  1    15.062 ? 1265 LEU A HD12   1 c 
ATOM   4165 H HD13   . LEU A 1 257 ? 25.506  -10.143 -0.811  1    15.05  ? 1265 LEU A HD13   1 c 
ATOM   4166 H HD21   . LEU A 1 257 ? 28.115  -10.158 -3.509  1    15.15  ? 1265 LEU A HD21   1 c 
ATOM   4167 H HD22   . LEU A 1 257 ? 27.961  -8.979  -2.181  1    15.155 ? 1265 LEU A HD22   1 c 
ATOM   4168 H HD23   . LEU A 1 257 ? 27.772  -10.72  -1.852  1    15.142 ? 1265 LEU A HD23   1 c 
ATOM   4169 N N      . LEU A 1 258 ? 24.413  -13.349 -5.332  1    14.49  ? 1266 LEU A N      1 ? 
ATOM   4170 C CA     . LEU A 1 258 ? 24.031  -14.724 -5.615  1    14.938 ? 1266 LEU A CA     1 ? 
ATOM   4171 C C      . LEU A 1 258 ? 24.864  -15.292 -6.757  1    16.136 ? 1266 LEU A C      1 ? 
ATOM   4172 O O      . LEU A 1 258 ? 25.368  -16.417 -6.672  1    15.795 ? 1266 LEU A O      1 ? 
ATOM   4173 C CB     . LEU A 1 258 ? 22.543  -14.795 -5.942  1    15.163 ? 1266 LEU A CB     1 ? 
ATOM   4174 C CG     . LEU A 1 258 ? 21.579  -14.515 -4.8    1    15.26  ? 1266 LEU A CG     1 ? 
ATOM   4175 C CD1    . LEU A 1 258 ? 20.152  -14.339 -5.304  1    15.837 ? 1266 LEU A CD1    1 ? 
ATOM   4176 C CD2    . LEU A 1 258 ? 21.673  -15.626 -3.705  1    14.687 ? 1266 LEU A CD2    1 ? 
ATOM   4177 H H      . LEU A 1 258 ? 23.699  -12.607 -5.452  1    13.878 ? 1266 LEU A H      1 ? 
ATOM   4178 H HA     . LEU A 1 258 ? 24.226  -15.319 -4.721  1    15.094 ? 1266 LEU A HA     1 c 
ATOM   4179 H HB2    . LEU A 1 258 ? 22.339  -14.082 -6.744  1    15.135 ? 1266 LEU A HB2    1 c 
ATOM   4180 H HB3    . LEU A 1 258 ? 22.33   -15.792 -6.333  1    15.135 ? 1266 LEU A HB3    1 c 
ATOM   4181 H HG     . LEU A 1 258 ? 21.879  -13.574 -4.335  1    15.235 ? 1266 LEU A HG     1 c 
ATOM   4182 H HD11   . LEU A 1 258 ? 20.112  -13.501 -6.002  1    15.673 ? 1266 LEU A HD11   1 c 
ATOM   4183 H HD12   . LEU A 1 258 ? 19.83   -15.25  -5.812  1    15.673 ? 1266 LEU A HD12   1 c 
ATOM   4184 H HD13   . LEU A 1 258 ? 19.488  -14.141 -4.46   1    15.666 ? 1266 LEU A HD13   1 c 
ATOM   4185 H HD21   . LEU A 1 258 ? 22.683  -15.647 -3.291  1    14.845 ? 1266 LEU A HD21   1 c 
ATOM   4186 H HD22   . LEU A 1 258 ? 20.958  -15.414 -2.908  1    14.843 ? 1266 LEU A HD22   1 c 
ATOM   4187 H HD23   . LEU A 1 258 ? 21.443  -16.597 -4.15   1    14.85  ? 1266 LEU A HD23   1 c 
ATOM   4188 N N      . ASP A 1 259 ? 25.037  -14.509 -7.822  1    15.015 ? 1267 ASP A N      1 ? 
ATOM   4189 C CA     . ASP A 1 259 ? 25.826  -14.954 -8.954  1    16.893 ? 1267 ASP A CA     1 ? 
ATOM   4190 C C      . ASP A 1 259 ? 27.278  -15.206 -8.536  1    17.014 ? 1267 ASP A C      1 ? 
ATOM   4191 O O      . ASP A 1 259 ? 27.959  -16.046 -9.124  1    18.08  ? 1267 ASP A O      1 ? 
ATOM   4192 C CB     . ASP A 1 259 ? 25.777  -13.881 -10.028 1    16.879 ? 1267 ASP A CB     1 ? 
ATOM   4193 C CG     . ASP A 1 259 ? 24.48   -13.873 -10.807 1    18.791 ? 1267 ASP A CG     1 ? 
ATOM   4194 O OD1    . ASP A 1 259 ? 23.615  -14.737 -10.568 1    20.837 ? 1267 ASP A OD1    1 ? 
ATOM   4195 O OD2    . ASP A 1 259 ? 24.301  -12.978 -11.639 1    22.872 ? 1267 ASP A OD2    1 ? 
ATOM   4196 H H      . ASP A 1 259 ? 24.552  -13.61  -7.877  1    15.44  ? 1267 ASP A H      1 ? 
ATOM   4197 H HA     . ASP A 1 259 ? 25.403  -15.883 -9.338  1    16.54  ? 1267 ASP A HA     1 c 
ATOM   4198 H HB2    . ASP A 1 259 ? 25.906  -12.902 -9.561  1    17.344 ? 1267 ASP A HB2    1 c 
ATOM   4199 H HB3    . ASP A 1 259 ? 26.601  -14.036 -10.727 1    17.298 ? 1267 ASP A HB3    1 c 
ATOM   4200 N N      . GLY A 1 260 ? 27.759  -14.48  -7.529  1    17.238 ? 1268 GLY A N      1 ? 
ATOM   4201 C CA     . GLY A 1 260 ? 29.096  -14.654 -7.004  1    16.938 ? 1268 GLY A CA     1 ? 
ATOM   4202 C C      . GLY A 1 260 ? 29.264  -15.794 -6.01   1    19.205 ? 1268 GLY A C      1 ? 
ATOM   4203 O O      . GLY A 1 260 ? 30.366  -15.988 -5.514  1    16.918 ? 1268 GLY A O      1 ? 
ATOM   4204 H H      . GLY A 1 260 ? 27.207  -13.668 -7.21   1    17.022 ? 1268 GLY A H      1 ? 
ATOM   4205 H HA2    . GLY A 1 260 ? 29.776  -14.816 -7.842  1    17.474 ? 1268 GLY A HA2    1 c 
ATOM   4206 H HA3    . GLY A 1 260 ? 29.396  -13.722 -6.52   1    17.458 ? 1268 GLY A HA3    1 c 
ATOM   4207 N N      . GLY A 1 261 ? 28.198  -16.527 -5.707  1    17.386 ? 1269 GLY A N      1 ? 
ATOM   4208 C CA     . GLY A 1 261 ? 28.294  -17.682 -4.837  1    16.746 ? 1269 GLY A CA     1 ? 
ATOM   4209 C C      . GLY A 1 261 ? 27.697  -17.521 -3.444  1    15.802 ? 1269 GLY A C      1 ? 
ATOM   4210 O O      . GLY A 1 261 ? 27.863  -18.411 -2.615  1    15.567 ? 1269 GLY A O      1 ? 
ATOM   4211 H H      . GLY A 1 261 ? 27.272  -16.272 -6.087  1    17.823 ? 1269 GLY A H      1 ? 
ATOM   4212 H HA2    . GLY A 1 261 ? 27.801  -18.521 -5.332  1    16.771 ? 1269 GLY A HA2    1 c 
ATOM   4213 H HA3    . GLY A 1 261 ? 29.349  -17.945 -4.734  1    16.681 ? 1269 GLY A HA3    1 c 
ATOM   4214 N N      . ALA A 1 262 ? 26.982  -16.435 -3.175  1    16.109 ? 1270 ALA A N      1 ? 
ATOM   4215 C CA     . ALA A 1 262 ? 26.415  -16.222 -1.849  1    14.356 ? 1270 ALA A CA     1 ? 
ATOM   4216 C C      . ALA A 1 262 ? 25.416  -17.321 -1.485  1    13.928 ? 1270 ALA A C      1 ? 
ATOM   4217 O O      . ALA A 1 262 ? 24.656  -17.804 -2.327  1    15.314 ? 1270 ALA A O      1 ? 
ATOM   4218 C CB     . ALA A 1 262 ? 25.725  -14.878 -1.794  1    14.237 ? 1270 ALA A CB     1 ? 
ATOM   4219 H H      . ALA A 1 262 ? 26.812  -15.721 -3.911  1    15.469 ? 1270 ALA A H      1 ? 
ATOM   4220 H HA     . ALA A 1 262 ? 27.229  -16.24  -1.121  1    14.576 ? 1270 ALA A HA     1 c 
ATOM   4221 H HB1    . ALA A 1 262 ? 24.94   -14.838 -2.553  1    14.297 ? 1270 ALA A HB1    1 c 
ATOM   4222 H HB2    . ALA A 1 262 ? 25.28   -14.734 -0.807  1    14.297 ? 1270 ALA A HB2    1 c 
ATOM   4223 H HB3    . ALA A 1 262 ? 26.449  -14.084 -1.982  1    14.383 ? 1270 ALA A HB3    1 c 
ATOM   4224 N N      . HIS A 1 263 ? 25.405  -17.675 -0.204  1    13.419 ? 1271 HIS A N      1 ? 
ATOM   4225 C CA     . HIS A 1 263 ? 24.334  -18.465 0.368   1    14.089 ? 1271 HIS A CA     1 ? 
ATOM   4226 C C      . HIS A 1 263 ? 23.178  -17.554 0.74    1    12.899 ? 1271 HIS A C      1 ? 
ATOM   4227 O O      . HIS A 1 263 ? 23.386  -16.427 1.196   1    14.23  ? 1271 HIS A O      1 ? 
ATOM   4228 C CB     . HIS A 1 263 ? 24.834  -19.176 1.629   1    13.993 ? 1271 HIS A CB     1 ? 
ATOM   4229 C CG     . HIS A 1 263 ? 25.822  -20.234 1.324   1    14.405 ? 1271 HIS A CG     1 ? 
ATOM   4230 N ND1    . HIS A 1 263 ? 25.454  -21.484 0.88    1    14.878 ? 1271 HIS A ND1    1 ? 
ATOM   4231 C CD2    . HIS A 1 263 ? 27.183  -20.208 1.325   1    13.885 ? 1271 HIS A CD2    1 ? 
ATOM   4232 C CE1    . HIS A 1 263 ? 26.544  -22.2   0.637   1    13.364 ? 1271 HIS A CE1    1 ? 
ATOM   4233 N NE2    . HIS A 1 263 ? 27.606  -21.446 0.905   1    13.98  ? 1271 HIS A NE2    1 ? 
ATOM   4234 H H      . HIS A 1 263 ? 26.079  -17.225 0.44    1    13.752 ? 1271 HIS A H      1 ? 
ATOM   4235 H HA     . HIS A 1 263 ? 23.987  -19.196 -0.365  1    13.721 ? 1271 HIS A HA     1 c 
ATOM   4236 H HB2    . HIS A 1 263 ? 25.292  -18.439 2.292   1    14.105 ? 1271 HIS A HB2    1 c 
ATOM   4237 H HB3    . HIS A 1 263 ? 23.981  -19.621 2.145   1    14.105 ? 1271 HIS A HB3    1 c 
ATOM   4238 H HD2    . HIS A 1 263 ? 27.821  -19.377 1.608   1    14.013 ? 1271 HIS A HD2    1 c 
ATOM   4239 H HE1    . HIS A 1 263 ? 26.563  -23.23  0.298   1    13.818 ? 1271 HIS A HE1    1 c 
ATOM   4240 H HE2    . HIS A 1 263 ? 28.551  -21.746 0.816   1    13.892 ? 1271 HIS A HE2    1 ? 
ATOM   4241 N N      . ILE A 1 264 ? 21.96   -18.051 0.555   1    12.39  ? 1272 ILE A N      1 ? 
ATOM   4242 C CA     . ILE A 1 264 ? 20.777  -17.328 0.958   1    12.747 ? 1272 ILE A CA     1 ? 
ATOM   4243 C C      . ILE A 1 264 ? 19.883  -18.273 1.764   1    13.374 ? 1272 ILE A C      1 ? 
ATOM   4244 O O      . ILE A 1 264 ? 19.723  -19.451 1.419   1    13.439 ? 1272 ILE A O      1 ? 
ATOM   4245 C CB     . ILE A 1 264 ? 20.068  -16.655 -0.239  1    15.426 ? 1272 ILE A CB     1 ? 
ATOM   4246 C CG1    . ILE A 1 264 ? 18.932  -15.732 0.242   1    15.064 ? 1272 ILE A CG1    1 ? 
ATOM   4247 C CG2    . ILE A 1 264 ? 19.586  -17.673 -1.276  1    13.767 ? 1272 ILE A CG2    1 ? 
ATOM   4248 C CD1    . ILE A 1 264 ? 18.45   -14.752 -0.806  1    14.91  ? 1272 ILE A CD1    1 ? 
ATOM   4249 H H      . ILE A 1 264 ? 21.86   -18.951 0.049   1    11.155 ? 1272 ILE A H      1 ? 
ATOM   4250 H HA     . ILE A 1 264 ? 21.097  -16.532 1.629   1    13.223 ? 1272 ILE A HA     1 c 
ATOM   4251 H HB     . ILE A 1 264 ? 20.807  -16.019 -0.731  1    14.541 ? 1272 ILE A HB     1 c 
ATOM   4252 H HG12   . ILE A 1 264 ? 18.089  -16.35  0.559   1    15.104 ? 1272 ILE A HG12   1 c 
ATOM   4253 H HG13   . ILE A 1 264 ? 19.281  -15.172 1.112   1    15.092 ? 1272 ILE A HG13   1 c 
ATOM   4254 H HG21   . ILE A 1 264 ? 18.858  -18.346 -0.819  1    14.194 ? 1272 ILE A HG21   1 c 
ATOM   4255 H HG22   . ILE A 1 264 ? 19.119  -17.15  -2.113  1    14.202 ? 1272 ILE A HG22   1 c 
ATOM   4256 H HG23   . ILE A 1 264 ? 20.436  -18.254 -1.641  1    14.165 ? 1272 ILE A HG23   1 c 
ATOM   4257 H HD11   . ILE A 1 264 ? 17.652  -14.134 -0.39   1    14.954 ? 1272 ILE A HD11   1 c 
ATOM   4258 H HD12   . ILE A 1 264 ? 19.279  -14.113 -1.117  1    14.954 ? 1272 ILE A HD12   1 c 
ATOM   4259 H HD13   . ILE A 1 264 ? 18.07   -15.299 -1.672  1    14.959 ? 1272 ILE A HD13   1 c 
ATOM   4260 N N      . TYR A 1 265 ? 19.342  -17.747 2.862   1    13.475 ? 1273 TYR A N      1 ? 
ATOM   4261 C CA     . TYR A 1 265 ? 18.621  -18.512 3.865   1    13.251 ? 1273 TYR A CA     1 ? 
ATOM   4262 C C      . TYR A 1 265 ? 17.265  -17.871 4.095   1    11.853 ? 1273 TYR A C      1 ? 
ATOM   4263 O O      . TYR A 1 265 ? 17.144  -16.645 4.109   1    12.357 ? 1273 TYR A O      1 ? 
ATOM   4264 C CB     . TYR A 1 265 ? 19.343  -18.496 5.226   1    12.967 ? 1273 TYR A CB     1 ? 
ATOM   4265 C CG     . TYR A 1 265 ? 20.797  -18.907 5.157   1    13.809 ? 1273 TYR A CG     1 ? 
ATOM   4266 C CD1    . TYR A 1 265 ? 21.772  -18.019 4.709   1    12.621 ? 1273 TYR A CD1    1 ? 
ATOM   4267 C CD2    . TYR A 1 265 ? 21.196  -20.195 5.509   1    13.092 ? 1273 TYR A CD2    1 ? 
ATOM   4268 C CE1    . TYR A 1 265 ? 23.096  -18.388 4.624   1    13.581 ? 1273 TYR A CE1    1 ? 
ATOM   4269 C CE2    . TYR A 1 265 ? 22.526  -20.576 5.436   1    13.061 ? 1273 TYR A CE2    1 ? 
ATOM   4270 C CZ     . TYR A 1 265 ? 23.472  -19.675 4.974   1    14.187 ? 1273 TYR A CZ     1 ? 
ATOM   4271 O OH     . TYR A 1 265 ? 24.777  -20.071 4.895   1    15.735 ? 1273 TYR A OH     1 ? 
ATOM   4272 H H      . TYR A 1 265 ? 19.535  -16.751 3.065   1    12.933 ? 1273 TYR A H      1 ? 
ATOM   4273 H HA     . TYR A 1 265 ? 18.496  -19.538 3.526   1    13.003 ? 1273 TYR A HA     1 c 
ATOM   4274 H HB2    . TYR A 1 265 ? 19.28   -17.487 5.64    1    13.207 ? 1273 TYR A HB2    1 c 
ATOM   4275 H HB3    . TYR A 1 265 ? 18.818  -19.17  5.905   1    13.198 ? 1273 TYR A HB3    1 c 
ATOM   4276 H HD1    . TYR A 1 265 ? 21.483  -17.015 4.421   1    13.089 ? 1273 TYR A HD1    1 c 
ATOM   4277 H HD2    . TYR A 1 265 ? 20.456  -20.908 5.857   1    13.244 ? 1273 TYR A HD2    1 c 
ATOM   4278 H HE1    . TYR A 1 265 ? 23.839  -17.681 4.269   1    13.499 ? 1273 TYR A HE1    1 c 
ATOM   4279 H HE2    . TYR A 1 265 ? 22.821  -21.583 5.708   1    13.32  ? 1273 TYR A HE2    1 c 
ATOM   4280 H HH     . TYR A 1 265 ? 25.305  -19.304 4.607   1    14.518 ? 1273 TYR A HH     1 ? 
ATOM   4281 N N      . PHE A 1 266 ? 16.262  -18.711 4.341   1    12.469 ? 1274 PHE A N      1 ? 
ATOM   4282 C CA     . PHE A 1 266 ? 14.92   -18.25  4.648   1    12.888 ? 1274 PHE A CA     1 ? 
ATOM   4283 C C      . PHE A 1 266 ? 14.402  -19.006 5.86    1    14.467 ? 1274 PHE A C      1 ? 
ATOM   4284 O O      . PHE A 1 266 ? 14.473  -20.239 5.901   1    13.258 ? 1274 PHE A O      1 ? 
ATOM   4285 C CB     . PHE A 1 266 ? 13.979  -18.501 3.469   1    12.751 ? 1274 PHE A CB     1 ? 
ATOM   4286 C CG     . PHE A 1 266 ? 14.427  -17.841 2.199   1    13.231 ? 1274 PHE A CG     1 ? 
ATOM   4287 C CD1    . PHE A 1 266 ? 15.317  -18.474 1.347   1    13.635 ? 1274 PHE A CD1    1 ? 
ATOM   4288 C CD2    . PHE A 1 266 ? 13.977  -16.573 1.881   1    13     ? 1274 PHE A CD2    1 ? 
ATOM   4289 C CE1    . PHE A 1 266 ? 15.733  -17.858 0.174   1    14.968 ? 1274 PHE A CE1    1 ? 
ATOM   4290 C CE2    . PHE A 1 266 ? 14.395  -15.947 0.722   1    13.893 ? 1274 PHE A CE2    1 ? 
ATOM   4291 C CZ     . PHE A 1 266 ? 15.276  -16.591 -0.132  1    14.446 ? 1274 PHE A CZ     1 ? 
ATOM   4292 H H      . PHE A 1 266 ? 16.458  -19.73  4.364   1    12.722 ? 1274 PHE A H      1 ? 
ATOM   4293 H HA     . PHE A 1 266 ? 14.946  -17.185 4.868   1    13.057 ? 1274 PHE A HA     1 c 
ATOM   4294 H HB2    . PHE A 1 266 ? 13.906  -19.578 3.304   1    12.886 ? 1274 PHE A HB2    1 c 
ATOM   4295 H HB3    . PHE A 1 266 ? 12.986  -18.13  3.731   1    12.886 ? 1274 PHE A HB3    1 c 
ATOM   4296 H HD1    . PHE A 1 266 ? 15.676  -19.468 1.59    1    13.861 ? 1274 PHE A HD1    1 c 
ATOM   4297 H HD2    . PHE A 1 266 ? 13.289  -16.066 2.549   1    13.26  ? 1274 PHE A HD2    1 c 
ATOM   4298 H HE1    . PHE A 1 266 ? 16.426  -18.364 -0.49   1    14.547 ? 1274 PHE A HE1    1 c 
ATOM   4299 H HE2    . PHE A 1 266 ? 14.03   -14.954 0.479   1    13.848 ? 1274 PHE A HE2    1 c 
ATOM   4300 H HZ     . PHE A 1 266 ? 15.601  -16.104 -1.046  1    14.412 ? 1274 PHE A HZ     1 c 
ATOM   4301 N N      . CYS A 1 267 ? 13.868  -18.265 6.83    1    14.154 ? 1275 CYS A N      1 ? 
ATOM   4302 C CA     . CYS A 1 267 ? 13.352  -18.891 8.032   1    14.499 ? 1275 CYS A CA     1 ? 
ATOM   4303 C C      . CYS A 1 267 ? 12.209  -18.064 8.597   1    13.722 ? 1275 CYS A C      1 ? 
ATOM   4304 O O      . CYS A 1 267 ? 12.252  -16.828 8.58    1    11.741 ? 1275 CYS A O      1 ? 
ATOM   4305 C CB     . CYS A 1 267 ? 14.465  -19.036 9.073   1    15.706 ? 1275 CYS A CB     1 ? 
ATOM   4306 S SG     . CYS A 1 267 ? 14.084  -20.16  10.446  1    15.021 ? 1275 CYS A SG     1 ? 
ATOM   4307 H H      . CYS A 1 267 ? 13.967  -17.23  6.816   1    13.911 ? 1275 CYS A H      1 ? 
ATOM   4308 H HA     . CYS A 1 267 ? 12.97   -19.875 7.767   1    14.503 ? 1275 CYS A HA     1 c 
ATOM   4309 H HB2    . CYS A 1 267 ? 15.366  -19.4   8.575   1    15.295 ? 1275 CYS A HB2    1 c 
ATOM   4310 H HB3    . CYS A 1 267 ? 14.69   -18.052 9.486   1    15.286 ? 1275 CYS A HB3    1 c 
ATOM   4311 H HG     . CYS A 1 267 ? 13.604  -21.232 9.825   1    15.182 ? 1275 CYS A HG     1 ? 
ATOM   4312 N N      . GLY A 1 268 ? 11.195  -18.765 9.112   1    14.498 ? 1276 GLY A N      1 ? 
ATOM   4313 C CA     . GLY A 1 268 ? 10.015  -18.149 9.682   1    13.956 ? 1276 GLY A CA     1 ? 
ATOM   4314 C C      . GLY A 1 268 ? 8.777   -18.908 9.236   1    14.227 ? 1276 GLY A C      1 ? 
ATOM   4315 O O      . GLY A 1 268 ? 8.853   -20.049 8.796   1    14.341 ? 1276 GLY A O      1 ? 
ATOM   4316 H H      . GLY A 1 268 ? 11.269  -19.8   9.152   1    14.341 ? 1276 GLY A H      1 ? 
ATOM   4317 H HA2    . GLY A 1 268 ? 10.087  -18.157 10.772  1    14.134 ? 1276 GLY A HA2    1 c 
ATOM   4318 H HA3    . GLY A 1 268 ? 9.952   -17.112 9.347   1    14.124 ? 1276 GLY A HA3    1 c 
ATOM   4319 N N      . LEU A 1 269 ? 7.625   -18.259 9.349   1    15.488 ? 1277 LEU A N      1 ? 
ATOM   4320 C CA     . LEU A 1 269 ? 6.382   -18.893 8.936   1    17.434 ? 1277 LEU A CA     1 ? 
ATOM   4321 C C      . LEU A 1 269 ? 6.365   -19.13  7.428   1    18.141 ? 1277 LEU A C      1 ? 
ATOM   4322 O O      . LEU A 1 269 ? 6.792   -18.28  6.653   1    18.657 ? 1277 LEU A O      1 ? 
ATOM   4323 C CB     . LEU A 1 269 ? 5.185   -18.037 9.336   1    19.587 ? 1277 LEU A CB     1 ? 
ATOM   4324 C CG     . LEU A 1 269 ? 4.921   -17.953 10.846  1    20.398 ? 1277 LEU A CG     1 ? 
ATOM   4325 C CD1    . LEU A 1 269 ? 3.746   -17.094 11.164  1    21.479 ? 1277 LEU A CD1    1 ? 
ATOM   4326 C CD2    . LEU A 1 269 ? 4.718   -19.285 11.476  1    20.155 ? 1277 LEU A CD2    1 ? 
ATOM   4327 H H      . LEU A 1 269 ? 7.597   -17.298 9.737   1    16.493 ? 1277 LEU A H      1 ? 
ATOM   4328 H HA     . LEU A 1 269 ? 6.314   -19.859 9.435   1    17.584 ? 1277 LEU A HA     1 c 
ATOM   4329 H HB2    . LEU A 1 269 ? 5.345   -17.025 8.956   1    19.27  ? 1277 LEU A HB2    1 c 
ATOM   4330 H HB3    . LEU A 1 269 ? 4.296   -18.443 8.851   1    19.308 ? 1277 LEU A HB3    1 c 
ATOM   4331 H HG     . LEU A 1 269 ? 5.796   -17.499 11.314  1    20.434 ? 1277 LEU A HG     1 c 
ATOM   4332 H HD11   . LEU A 1 269 ? 3.914   -16.088 10.777  1    21.237 ? 1277 LEU A HD11   1 c 
ATOM   4333 H HD12   . LEU A 1 269 ? 2.852   -17.515 10.7    1    21.19  ? 1277 LEU A HD12   1 c 
ATOM   4334 H HD13   . LEU A 1 269 ? 3.605   -17.051 12.245  1    21.216 ? 1277 LEU A HD13   1 c 
ATOM   4335 H HD21   . LEU A 1 269 ? 4.51    -19.157 12.54   1    20.232 ? 1277 LEU A HD21   1 c 
ATOM   4336 H HD22   . LEU A 1 269 ? 3.875   -19.787 11.002  1    20.305 ? 1277 LEU A HD22   1 c 
ATOM   4337 H HD23   . LEU A 1 269 ? 5.618   -19.891 11.354  1    20.187 ? 1277 LEU A HD23   1 c 
ATOM   4338 N N      . LYS A 1 270 ? 5.845   -20.285 7.025   1    19.241 ? 1278 LYS A N      1 ? 
ATOM   4339 C CA     . LYS A 1 270 ? 5.882   -20.669 5.621   1    21.05  ? 1278 LYS A CA     1 ? 
ATOM   4340 C C      . LYS A 1 270 ? 5.137   -19.679 4.726   1    20.565 ? 1278 LYS A C      1 ? 
ATOM   4341 O O      . LYS A 1 270 ? 5.448   -19.576 3.536   1    20.531 ? 1278 LYS A O      1 ? 
ATOM   4342 C CB     . LYS A 1 270 ? 5.345   -22.09  5.439   1    24.211 ? 1278 LYS A CB     1 ? 
ATOM   4343 C CG     . LYS A 1 270 ? 3.864   -22.243 5.842   1    34.12  ? 1278 LYS A CG     1 ? 
ATOM   4344 C CD     . LYS A 1 270 ? 3.261   -23.652 5.797   1    40.447 ? 1278 LYS A CD     1 ? 
ATOM   4345 C CE     . LYS A 1 270 ? 4.048   -24.71  6.521   1    50.638 ? 1278 LYS A CE     1 ? 
ATOM   4346 N NZ     . LYS A 1 270 ? 3.355   -26.009 6.608   1    58.884 ? 1278 LYS A NZ     1 ? 
ATOM   4347 H H      . LYS A 1 270 ? 5.504   -20.955 7.734   1    17.743 ? 1278 LYS A H      1 ? 
ATOM   4348 H HA     . LYS A 1 270 ? 6.924   -20.673 5.305   1    21.082 ? 1278 LYS A HA     1 c 
ATOM   4349 H HB2    . LYS A 1 270 ? 5.454   -22.381 4.392   1    25.33  ? 1278 LYS A HB2    1 c 
ATOM   4350 H HB3    . LYS A 1 270 ? 5.944   -22.776 6.041   1    25.405 ? 1278 LYS A HB3    1 c 
ATOM   4351 H HG2    . LYS A 1 270 ? 3.752   -21.856 6.856   1    32.515 ? 1278 LYS A HG2    1 c 
ATOM   4352 H HG3    . LYS A 1 270 ? 3.271   -21.598 5.191   1    32.696 ? 1278 LYS A HG3    1 c 
ATOM   4353 H HD2    . LYS A 1 270 ? 2.256   -23.612 6.222   1    40.974 ? 1278 LYS A HD2    1 c 
ATOM   4354 H HD3    . LYS A 1 270 ? 3.158   -23.948 4.751   1    40.974 ? 1278 LYS A HD3    1 c 
ATOM   4355 H HE2    . LYS A 1 270 ? 5.004   -24.856 6.012   1    49.867 ? 1278 LYS A HE2    1 c 
ATOM   4356 H HE3    . LYS A 1 270 ? 4.262   -24.361 7.534   1    49.865 ? 1278 LYS A HE3    1 c 
ATOM   4357 H HZ1    . LYS A 1 270 ? 2.351   -25.848 6.777   1    57.86  ? 1278 LYS A HZ1    1 ? 
ATOM   4358 H HZ2    . LYS A 1 270 ? 3.487   -26.561 5.746   1    56.395 ? 1278 LYS A HZ2    1 ? 
ATOM   4359 H HZ3    . LYS A 1 270 ? 3.748   -26.554 7.38    1    55.081 ? 1278 LYS A HZ3    1 ? 
ATOM   4360 N N      . GLY A 1 271 ? 4.185   -18.929 5.278   1    21.395 ? 1279 GLY A N      1 ? 
ATOM   4361 C CA     . GLY A 1 271 ? 3.5     -17.917 4.5     1    21.697 ? 1279 GLY A CA     1 ? 
ATOM   4362 C C      . GLY A 1 271 ? 4.397   -16.798 4.007   1    22.809 ? 1279 GLY A C      1 ? 
ATOM   4363 O O      . GLY A 1 271 ? 3.944   -15.987 3.21    1    22.959 ? 1279 GLY A O      1 ? 
ATOM   4364 H H      . GLY A 1 271 ? 3.837   -19.132 6.226   1    20.165 ? 1279 GLY A H      1 ? 
ATOM   4365 H HA2    . GLY A 1 271 ? 3.033   -18.399 3.64    1    21.953 ? 1279 GLY A HA2    1 c 
ATOM   4366 H HA3    . GLY A 1 271 ? 2.7     -17.49  5.109   1    21.907 ? 1279 GLY A HA3    1 c 
ATOM   4367 N N      . MET A 1 272 ? 5.659   -16.723 4.456   1    21.02  ? 1280 MET A N      1 ? 
ATOM   4368 C CA     . MET A 1 272 ? 6.536   -15.642 3.988   1    20.91  ? 1280 MET A CA     1 ? 
ATOM   4369 C C      . MET A 1 272 ? 6.941   -15.927 2.531   1    18.182 ? 1280 MET A C      1 ? 
ATOM   4370 O O      . MET A 1 272 ? 7.371   -15.015 1.815   1    19.193 ? 1280 MET A O      1 ? 
ATOM   4371 C CB     . MET A 1 272 ? 7.871   -15.498 4.801   1    19.762 ? 1280 MET A CB     1 ? 
ATOM   4372 C CG     . MET A 1 272 ? 8.742   -16.738 4.838   1    19.123 ? 1280 MET A CG     1 ? 
ATOM   4373 S SD     . MET A 1 272 ? 10.012  -16.612 6.117   1    19.072 ? 1280 MET A SD     1 ? 
ATOM   4374 C CE     . MET A 1 272 ? 11.253  -15.675 5.24    1    18.86  ? 1280 MET A CE     1 ? 
ATOM   4375 H H      . MET A 1 272 ? 5.953   -17.334 5.236   1    22.472 ? 1280 MET A H      1 ? 
ATOM   4376 H HA     . MET A 1 272 ? 5.981   -14.702 4.024   1    20.237 ? 1280 MET A HA     1 c 
ATOM   4377 H HB2    . MET A 1 272 ? 8.449   -14.678 4.369   1    19.856 ? 1280 MET A HB2    1 c 
ATOM   4378 H HB3    . MET A 1 272 ? 7.619   -15.217 5.826   1    19.856 ? 1280 MET A HB3    1 c 
ATOM   4379 H HG2    . MET A 1 272 ? 8.127   -17.616 5.029   1    19.253 ? 1280 MET A HG2    1 c 
ATOM   4380 H HG3    . MET A 1 272 ? 9.228   -16.868 3.87    1    19.247 ? 1280 MET A HG3    1 c 
ATOM   4381 H HE1    . MET A 1 272 ? 10.835  -14.712 4.939   1    18.912 ? 1280 MET A HE1    1 c 
ATOM   4382 H HE2    . MET A 1 272 ? 12.113  -15.511 5.893   1    18.912 ? 1280 MET A HE2    1 c 
ATOM   4383 H HE3    . MET A 1 272 ? 11.568  -16.229 4.354   1    18.916 ? 1280 MET A HE3    1 c 
ATOM   4384 N N      . MET A 1 273 ? 7.041   -17.219 2.169   1    18.752 ? 1281 MET A N      1 ? 
ATOM   4385 C CA     . MET A 1 273 ? 7.616   -17.649 0.889   1    19.534 ? 1281 MET A CA     1 ? 
ATOM   4386 C C      . MET A 1 273 ? 6.878   -17.198 -0.382  1    19.101 ? 1281 MET A C      1 ? 
ATOM   4387 O O      . MET A 1 273 ? 7.568   -16.795 -1.33   1    22.01  ? 1281 MET A O      1 ? 
ATOM   4388 C CB     . MET A 1 273 ? 8.04    -19.146 0.879   1    19.754 ? 1281 MET A CB     1 ? 
ATOM   4389 C CG     . MET A 1 273 ? 9.057   -19.581 1.943   1    20.657 ? 1281 MET A CG     1 ? 
ATOM   4390 S SD     . MET A 1 273 ? 10.545  -18.531 1.984   1    18.208 ? 1281 MET A SD     1 ? 
ATOM   4391 C CE     . MET A 1 273 ? 11.224  -19.01  0.39    1    16.728 ? 1281 MET A CE     1 ? 
ATOM   4392 H H      . MET A 1 273 ? 6.607   -17.952 2.751   1    20.438 ? 1281 MET A H      1 ? 
ATOM   4393 H HA     . MET A 1 273 ? 8.55    -17.089 0.827   1    19.332 ? 1281 MET A HA     1 c 
ATOM   4394 H HB2    . MET A 1 273 ? 7.14    -19.753 0.995   1    19.894 ? 1281 MET A HB2    1 c 
ATOM   4395 H HB3    . MET A 1 273 ? 8.457   -19.371 -0.105  1    19.872 ? 1281 MET A HB3    1 c 
ATOM   4396 H HG2    . MET A 1 273 ? 8.582   -19.551 2.926   1    20.001 ? 1281 MET A HG2    1 c 
ATOM   4397 H HG3    . MET A 1 273 ? 9.361   -20.61  1.751   1    20.062 ? 1281 MET A HG3    1 c 
ATOM   4398 H HE1    . MET A 1 273 ? 10.515  -18.752 -0.4    1    17.112 ? 1281 MET A HE1    1 c 
ATOM   4399 H HE2    . MET A 1 273 ? 12.165  -18.481 0.222   1    17.095 ? 1281 MET A HE2    1 c 
ATOM   4400 H HE3    . MET A 1 273 ? 11.405  -20.086 0.38    1    17.161 ? 1281 MET A HE3    1 c 
ATOM   4401 N N      . PRO A 1 274 ? 5.54    -17.296 -0.509  1    23.533 ? 1282 PRO A N      1 ? 
ATOM   4402 C CA     . PRO A 1 274 ? 4.955   -16.948 -1.806  1    22.266 ? 1282 PRO A CA     1 ? 
ATOM   4403 C C      . PRO A 1 274 ? 5.289   -15.533 -2.255  1    18.329 ? 1282 PRO A C      1 ? 
ATOM   4404 O O      . PRO A 1 274 ? 5.609   -15.309 -3.424  1    18.389 ? 1282 PRO A O      1 ? 
ATOM   4405 C CB     . PRO A 1 274 ? 3.452   -17.167 -1.587  1    22.794 ? 1282 PRO A CB     1 ? 
ATOM   4406 C CG     . PRO A 1 274 ? 3.421   -18.235 -0.513  1    21.927 ? 1282 PRO A CG     1 ? 
ATOM   4407 C CD     . PRO A 1 274 ? 4.556   -17.898 0.414   1    21.966 ? 1282 PRO A CD     1 ? 
ATOM   4408 H HA     . PRO A 1 274 ? 5.312   -17.654 -2.558  1    21.857 ? 1282 PRO A HA     1 c 
ATOM   4409 H HB2    . PRO A 1 274 ? 2.967   -16.25  -1.245  1    22.49  ? 1282 PRO A HB2    1 c 
ATOM   4410 H HB3    . PRO A 1 274 ? 2.968   -17.514 -2.502  1    22.49  ? 1282 PRO A HB3    1 c 
ATOM   4411 H HG2    . PRO A 1 274 ? 2.47    -18.218 0.024   1    22.12  ? 1282 PRO A HG2    1 c 
ATOM   4412 H HG3    . PRO A 1 274 ? 3.563   -19.227 -0.947  1    22.12  ? 1282 PRO A HG3    1 c 
ATOM   4413 H HD2    . PRO A 1 274 ? 4.25    -17.184 1.178   1    22.3   ? 1282 PRO A HD2    1 c 
ATOM   4414 H HD3    . PRO A 1 274 ? 4.964   -18.792 0.891   1    22.296 ? 1282 PRO A HD3    1 c 
ATOM   4415 N N      . GLY A 1 275 ? 5.208   -14.563 -1.352  1    18.666 ? 1283 GLY A N      1 ? 
ATOM   4416 C CA     . GLY A 1 275 ? 5.539   -13.196 -1.692  1    19.548 ? 1283 GLY A CA     1 ? 
ATOM   4417 C C      . GLY A 1 275 ? 7.003   -13.044 -2.112  1    21.468 ? 1283 GLY A C      1 ? 
ATOM   4418 O O      . GLY A 1 275 ? 7.329   -12.293 -3.041  1    18.547 ? 1283 GLY A O      1 ? 
ATOM   4419 H H      . GLY A 1 275 ? 4.831   -14.766 -0.411  1    20.012 ? 1283 GLY A H      1 ? 
ATOM   4420 H HA2    . GLY A 1 275 ? 4.888   -12.861 -2.502  1    19.731 ? 1283 GLY A HA2    1 c 
ATOM   4421 H HA3    . GLY A 1 275 ? 5.346   -12.566 -0.821  1    19.726 ? 1283 GLY A HA3    1 c 
ATOM   4422 N N      . ILE A 1 276 ? 7.893   -13.765 -1.42   1    19.965 ? 1284 ILE A N      1 ? 
ATOM   4423 C CA     . ILE A 1 276 ? 9.3     -13.727 -1.762  1    21.197 ? 1284 ILE A CA     1 ? 
ATOM   4424 C C      . ILE A 1 276 ? 9.527   -14.293 -3.17   1    17.06  ? 1284 ILE A C      1 ? 
ATOM   4425 O O      . ILE A 1 276 ? 10.232  -13.689 -3.996  1    18.034 ? 1284 ILE A O      1 ? 
ATOM   4426 C CB     . ILE A 1 276 ? 10.12   -14.472 -0.692  1    19.782 ? 1284 ILE A CB     1 ? 
ATOM   4427 C CG1    . ILE A 1 276 ? 10.204  -13.633 0.59    1    20.973 ? 1284 ILE A CG1    1 ? 
ATOM   4428 C CG2    . ILE A 1 276 ? 11.501  -14.82  -1.221  1    17.655 ? 1284 ILE A CG2    1 ? 
ATOM   4429 C CD1    . ILE A 1 276 ? 10.665  -14.406 1.818   1    21.609 ? 1284 ILE A CD1    1 ? 
ATOM   4430 H H      . ILE A 1 276 ? 7.56    -14.492 -0.748  1    21.595 ? 1284 ILE A H      1 ? 
ATOM   4431 H HA     . ILE A 1 276 ? 9.618   -12.683 -1.762  1    19.943 ? 1284 ILE A HA     1 c 
ATOM   4432 H HB     . ILE A 1 276 ? 9.601   -15.403 -0.454  1    19.825 ? 1284 ILE A HB     1 c 
ATOM   4433 H HG12   . ILE A 1 276 ? 10.893  -12.804 0.42    1    20.843 ? 1284 ILE A HG12   1 c 
ATOM   4434 H HG13   . ILE A 1 276 ? 9.218   -13.209 0.794   1    20.839 ? 1284 ILE A HG13   1 c 
ATOM   4435 H HG21   . ILE A 1 276 ? 11.415  -15.561 -2.018  1    18.219 ? 1284 ILE A HG21   1 c 
ATOM   4436 H HG22   . ILE A 1 276 ? 11.981  -13.92  -1.613  1    18.225 ? 1284 ILE A HG22   1 c 
ATOM   4437 H HG23   . ILE A 1 276 ? 12.107  -15.231 -0.413  1    18.239 ? 1284 ILE A HG23   1 c 
ATOM   4438 H HD11   . ILE A 1 276 ? 10.685  -13.739 2.683   1    21.413 ? 1284 ILE A HD11   1 c 
ATOM   4439 H HD12   . ILE A 1 276 ? 9.976   -15.23  2.012   1    21.413 ? 1284 ILE A HD12   1 c 
ATOM   4440 H HD13   . ILE A 1 276 ? 11.667  -14.804 1.646   1    21.357 ? 1284 ILE A HD13   1 c 
ATOM   4441 N N      . GLN A 1 277 ? 8.937   -15.454 -3.462  1    19.047 ? 1285 GLN A N      1 ? 
ATOM   4442 C CA     . GLN A 1 277 ? 9.068   -16.013 -4.8    1    19.242 ? 1285 GLN A CA     1 ? 
ATOM   4443 C C      . GLN A 1 277 ? 8.529   -15.06  -5.861  1    20.507 ? 1285 GLN A C      1 ? 
ATOM   4444 O O      . GLN A 1 277 ? 9.134   -14.899 -6.925  1    21.074 ? 1285 GLN A O      1 ? 
ATOM   4445 C CB     . GLN A 1 277 ? 8.362   -17.374 -4.902  1    20.607 ? 1285 GLN A CB     1 ? 
ATOM   4446 C CG     . GLN A 1 277 ? 8.948   -18.468 -4.015  1    20.505 ? 1285 GLN A CG     1 ? 
ATOM   4447 C CD     . GLN A 1 277 ? 10.247  -19.012 -4.561  1    19.683 ? 1285 GLN A CD     1 ? 
ATOM   4448 O OE1    . GLN A 1 277 ? 10.737  -18.56  -5.601  1    20.536 ? 1285 GLN A OE1    1 ? 
ATOM   4449 N NE2    . GLN A 1 277 ? 10.873  -19.893 -3.799  1    19.691 ? 1285 GLN A NE2    1 ? 
ATOM   4450 H H      . GLN A 1 277 ? 8.306   -15.911 -2.779  1    19.918 ? 1285 GLN A H      1 ? 
ATOM   4451 H HA     . GLN A 1 277 ? 10.131  -16.168 -4.994  1    19.666 ? 1285 GLN A HA     1 c 
ATOM   4452 H HB2    . GLN A 1 277 ? 7.311   -17.237 -4.64   1    20.281 ? 1285 GLN A HB2    1 c 
ATOM   4453 H HB3    . GLN A 1 277 ? 8.4     -17.706 -5.942  1    20.282 ? 1285 GLN A HB3    1 c 
ATOM   4454 H HG2    . GLN A 1 277 ? 9.123   -18.067 -3.015  1    20.343 ? 1285 GLN A HG2    1 c 
ATOM   4455 H HG3    . GLN A 1 277 ? 8.23    -19.286 -3.927  1    20.343 ? 1285 GLN A HG3    1 c 
ATOM   4456 H HE21   . GLN A 1 277 ? 10.463  -20.083 -2.882  1    18.538 ? 1285 GLN A HE21   1 ? 
ATOM   4457 H HE22   . GLN A 1 277 ? 11.751  -20.323 -4.112  1    18.346 ? 1285 GLN A HE22   1 ? 
ATOM   4458 N N      . ASP A 1 278 ? 7.396   -14.41  -5.584  1    24.003 ? 1286 ASP A N      1 ? 
ATOM   4459 C CA     . ASP A 1 278 ? 6.81    -13.491 -6.552  1    25.819 ? 1286 ASP A CA     1 ? 
ATOM   4460 C C      . ASP A 1 278 ? 7.753   -12.322 -6.823  1    21.812 ? 1286 ASP A C      1 ? 
ATOM   4461 O O      . ASP A 1 278 ? 7.962   -11.933 -7.981  1    21.957 ? 1286 ASP A O      1 ? 
ATOM   4462 C CB     . ASP A 1 278 ? 5.464   -12.988 -6.038  1    28.941 ? 1286 ASP A CB     1 ? 
ATOM   4463 C CG     . ASP A 1 278 ? 4.711   -12.032 -6.961  1    32.1   ? 1286 ASP A CG     1 ? 
ATOM   4464 O OD1    . ASP A 1 278 ? 4.256   -12.51  -8.027  1    31.203 ? 1286 ASP A OD1    1 ? 
ATOM   4465 O OD2    . ASP A 1 278 ? 4.597   -10.822 -6.613  1    30.329 ? 1286 ASP A OD2    1 ? 
ATOM   4466 H H      . ASP A 1 278 ? 6.931   -14.499 -4.663  1    23.985 ? 1286 ASP A H      1 ? 
ATOM   4467 H HA     . ASP A 1 278 ? 6.644   -14.033 -7.485  1    25.224 ? 1286 ASP A HA     1 c 
ATOM   4468 H HB2    . ASP A 1 278 ? 4.822   -13.848 -5.84   1    28.966 ? 1286 ASP A HB2    1 c 
ATOM   4469 H HB3    . ASP A 1 278 ? 5.63    -12.474 -5.088  1    28.895 ? 1286 ASP A HB3    1 c 
ATOM   4470 N N      . THR A 1 279 ? 8.328   -11.75  -5.756  1    20.572 ? 1287 THR A N      1 ? 
ATOM   4471 C CA     . THR A 1 279 ? 9.256   -10.639 -5.923  1    20.611 ? 1287 THR A CA     1 ? 
ATOM   4472 C C      . THR A 1 279 ? 10.496  -11.069 -6.704  1    18.836 ? 1287 THR A C      1 ? 
ATOM   4473 O O      . THR A 1 279 ? 10.943  -10.365 -7.614  1    20.039 ? 1287 THR A O      1 ? 
ATOM   4474 C CB     . THR A 1 279 ? 9.638   -10.067 -4.561  1    19.934 ? 1287 THR A CB     1 ? 
ATOM   4475 O OG1    . THR A 1 279 ? 8.513   -9.367  -4.013  1    20.801 ? 1287 THR A OG1    1 ? 
ATOM   4476 C CG2    . THR A 1 279 ? 10.811  -9.115  -4.688  1    22.475 ? 1287 THR A CG2    1 ? 
ATOM   4477 H H      . THR A 1 279 ? 8.035   -12.023 -4.805  1    21.973 ? 1287 THR A H      1 ? 
ATOM   4478 H HA     . THR A 1 279 ? 8.746   -9.858  -6.491  1    20.157 ? 1287 THR A HA     1 c 
ATOM   4479 H HB     . THR A 1 279 ? 9.915   -10.882 -3.89   1    20.65  ? 1287 THR A HB     1 c 
ATOM   4480 H HG1    . THR A 1 279 ? 8.793   -8.551  -3.588  1    21.32  ? 1287 THR A HG1    1 ? 
ATOM   4481 H HG21   . THR A 1 279 ? 10.602  -8.383  -5.471  1    21.721 ? 1287 THR A HG21   1 c 
ATOM   4482 H HG22   . THR A 1 279 ? 10.963  -8.596  -3.739  1    21.713 ? 1287 THR A HG22   1 c 
ATOM   4483 H HG23   . THR A 1 279 ? 11.712  -9.674  -4.945  1    21.685 ? 1287 THR A HG23   1 c 
ATOM   4484 N N      . LEU A 1 280 ? 11.065  -12.225 -6.353  1    19.082 ? 1288 LEU A N      1 ? 
ATOM   4485 C CA     . LEU A 1 280 ? 12.268  -12.672 -7.044  1    19.048 ? 1288 LEU A CA     1 ? 
ATOM   4486 C C      . LEU A 1 280 ? 11.999  -12.937 -8.523  1    18.859 ? 1288 LEU A C      1 ? 
ATOM   4487 O O      . LEU A 1 280 ? 12.842  -12.645 -9.38   1    17.214 ? 1288 LEU A O      1 ? 
ATOM   4488 C CB     . LEU A 1 280 ? 12.866  -13.895 -6.346  1    18.393 ? 1288 LEU A CB     1 ? 
ATOM   4489 C CG     . LEU A 1 280 ? 13.396  -13.59  -4.943  1    17.015 ? 1288 LEU A CG     1 ? 
ATOM   4490 C CD1    . LEU A 1 280 ? 13.67   -14.885 -4.176  1    18.648 ? 1288 LEU A CD1    1 ? 
ATOM   4491 C CD2    . LEU A 1 280 ? 14.648  -12.761 -5.031  1    18.554 ? 1288 LEU A CD2    1 ? 
ATOM   4492 H H      . LEU A 1 280 ? 10.748  -12.732 -5.51   1    19.149 ? 1288 LEU A H      1 ? 
ATOM   4493 H HA     . LEU A 1 280 ? 12.992  -11.858 -6.99   1    18.901 ? 1288 LEU A HA     1 c 
ATOM   4494 H HB2    . LEU A 1 280 ? 12.095  -14.664 -6.27   1    18.222 ? 1288 LEU A HB2    1 c 
ATOM   4495 H HB3    . LEU A 1 280 ? 13.688  -14.275 -6.956  1    18.222 ? 1288 LEU A HB3    1 c 
ATOM   4496 H HG     . LEU A 1 280 ? 12.639  -13.018 -4.402  1    17.824 ? 1288 LEU A HG     1 c 
ATOM   4497 H HD11   . LEU A 1 280 ? 13.942  -14.649 -3.145  1    18.187 ? 1288 LEU A HD11   1 c 
ATOM   4498 H HD12   . LEU A 1 280 ? 12.773  -15.509 -4.18   1    18.187 ? 1288 LEU A HD12   1 c 
ATOM   4499 H HD13   . LEU A 1 280 ? 14.489  -15.425 -4.652  1    18.207 ? 1288 LEU A HD13   1 c 
ATOM   4500 H HD21   . LEU A 1 280 ? 14.421  -11.8   -5.496  1    18.118 ? 1288 LEU A HD21   1 c 
ATOM   4501 H HD22   . LEU A 1 280 ? 15.045  -12.592 -4.027  1    18.113 ? 1288 LEU A HD22   1 c 
ATOM   4502 H HD23   . LEU A 1 280 ? 15.394  -13.288 -5.63   1    18.119 ? 1288 LEU A HD23   1 c 
ATOM   4503 N N      . LYS A 1 281 ? 10.814  -13.481 -8.836  1    22.008 ? 1289 LYS A N      1 ? 
ATOM   4504 C CA     . LYS A 1 281 ? 10.455  -13.691 -10.227 1    21.335 ? 1289 LYS A CA     1 ? 
ATOM   4505 C C      . LYS A 1 281 ? 10.397  -12.361 -10.982 1    19.322 ? 1289 LYS A C      1 ? 
ATOM   4506 O O      . LYS A 1 281 ? 10.907  -12.247 -12.106 1    19.925 ? 1289 LYS A O      1 ? 
ATOM   4507 C CB     . LYS A 1 281 ? 9.111   -14.404 -10.3   1    24.73  ? 1289 LYS A CB     1 ? 
ATOM   4508 C CG     . LYS A 1 281 ? 8.693   -14.944 -11.664 1    30.411 ? 1289 LYS A CG     1 ? 
ATOM   4509 C CD     . LYS A 1 281 ? 7.18    -14.98  -11.881 1    32.154 ? 1289 LYS A CD     1 ? 
ATOM   4510 C CE     . LYS A 1 281 ? 6.8     -15.921 -13.012 1    39.139 ? 1289 LYS A CE     1 ? 
ATOM   4511 N NZ     . LYS A 1 281 ? 5.343   -15.842 -13.185 1    46.524 ? 1289 LYS A NZ     1 ? 
ATOM   4512 H H      . LYS A 1 281 ? 10.178  -13.783 -8.076  1    20.938 ? 1289 LYS A H      1 ? 
ATOM   4513 H HA     . LYS A 1 281 ? 11.216  -14.32  -10.688 1    21.61  ? 1289 LYS A HA     1 c 
ATOM   4514 H HB2    . LYS A 1 281 ? 9.13    -15.239 -9.597  1    25.055 ? 1289 LYS A HB2    1 c 
ATOM   4515 H HB3    . LYS A 1 281 ? 8.339   -13.71  -9.96   1    25.055 ? 1289 LYS A HB3    1 c 
ATOM   4516 H HG2    . LYS A 1 281 ? 9.148   -14.324 -12.439 1    29.36  ? 1289 LYS A HG2    1 c 
ATOM   4517 H HG3    . LYS A 1 281 ? 9.091   -15.955 -11.771 1    29.452 ? 1289 LYS A HG3    1 c 
ATOM   4518 H HD2    . LYS A 1 281 ? 6.692   -15.311 -10.961 1    33.17  ? 1289 LYS A HD2    1 c 
ATOM   4519 H HD3    . LYS A 1 281 ? 6.825   -13.975 -12.115 1    33.17  ? 1289 LYS A HD3    1 c 
ATOM   4520 H HE2    . LYS A 1 281 ? 7.297   -15.622 -13.938 1    39.013 ? 1289 LYS A HE2    1 c 
ATOM   4521 H HE3    . LYS A 1 281 ? 7.086   -16.946 -12.768 1    39.041 ? 1289 LYS A HE3    1 c 
ATOM   4522 H HZ1    . LYS A 1 281 ? 5.104   -14.93  -13.573 1    43.792 ? 1289 LYS A HZ1    1 ? 
ATOM   4523 H HZ2    . LYS A 1 281 ? 5.004   -16.558 -13.818 1    42.752 ? 1289 LYS A HZ2    1 ? 
ATOM   4524 H HZ3    . LYS A 1 281 ? 4.855   -15.958 -12.278 1    43.703 ? 1289 LYS A HZ3    1 ? 
ATOM   4525 N N      . LYS A 1 282 ? 9.773   -11.347 -10.372 1    23.525 ? 1290 LYS A N      1 ? 
ATOM   4526 C CA     . LYS A 1 282 ? 9.632   -10.051 -11.015 1    24.989 ? 1290 LYS A CA     1 ? 
ATOM   4527 C C      . LYS A 1 282 ? 10.978  -9.345  -11.16  1    23.466 ? 1290 LYS A C      1 ? 
ATOM   4528 O O      . LYS A 1 282 ? 11.247  -8.705  -12.182 1    21.163 ? 1290 LYS A O      1 ? 
ATOM   4529 C CB     . LYS A 1 282 ? 8.633   -9.196  -10.236 1    30.267 ? 1290 LYS A CB     1 ? 
ATOM   4530 C CG     . LYS A 1 282 ? 7.188   -9.504  -10.64  1    38.591 ? 1290 LYS A CG     1 ? 
ATOM   4531 C CD     . LYS A 1 282 ? 6.112   -9.001  -9.688  1    44.299 ? 1290 LYS A CD     1 ? 
ATOM   4532 C CE     . LYS A 1 282 ? 4.716   -9.297  -10.187 1    50.594 ? 1290 LYS A CE     1 ? 
ATOM   4533 N NZ     . LYS A 1 282 ? 3.757   -9.14   -9.083  1    58.298 ? 1290 LYS A NZ     1 ? 
ATOM   4534 H H      . LYS A 1 282 ? 9.323   -11.491 -9.453  1    22.109 ? 1290 LYS A H      1 ? 
ATOM   4535 H HA     . LYS A 1 282 ? 9.226   -10.216 -12.015 1    25.279 ? 1290 LYS A HA     1 c 
ATOM   4536 H HB2    . LYS A 1 282 ? 8.75    -9.384  -9.166  1    30.614 ? 1290 LYS A HB2    1 c 
ATOM   4537 H HB3    . LYS A 1 282 ? 8.836   -8.139  -10.421 1    30.614 ? 1290 LYS A HB3    1 c 
ATOM   4538 H HG2    . LYS A 1 282 ? 7.011   -9.069  -11.626 1    37.708 ? 1290 LYS A HG2    1 c 
ATOM   4539 H HG3    . LYS A 1 282 ? 7.087   -10.586 -10.74  1    37.708 ? 1290 LYS A HG3    1 c 
ATOM   4540 H HD2    . LYS A 1 282 ? 6.25    -9.473  -8.713  1    44.262 ? 1290 LYS A HD2    1 c 
ATOM   4541 H HD3    . LYS A 1 282 ? 6.224   -7.922  -9.561  1    44.262 ? 1290 LYS A HD3    1 c 
ATOM   4542 H HE2    . LYS A 1 282 ? 4.454   -8.61   -10.994 1    50.755 ? 1290 LYS A HE2    1 c 
ATOM   4543 H HE3    . LYS A 1 282 ? 4.664   -10.319 -10.568 1    50.755 ? 1290 LYS A HE3    1 c 
ATOM   4544 H HZ1    . LYS A 1 282 ? 4.094   -8.389  -8.458  1    53.853 ? 1290 LYS A HZ1    1 ? 
ATOM   4545 H HZ2    . LYS A 1 282 ? 3.646   -10.031 -8.563  1    53.356 ? 1290 LYS A HZ2    1 ? 
ATOM   4546 H HZ3    . LYS A 1 282 ? 2.848   -8.897  -9.456  1    55.338 ? 1290 LYS A HZ3    1 ? 
ATOM   4547 N N      . VAL A 1 283 ? 11.828  -9.448  -10.141 1    21.091 ? 1291 VAL A N      1 ? 
ATOM   4548 C CA     . VAL A 1 283 ? 13.168  -8.878  -10.224 1    20.13  ? 1291 VAL A CA     1 ? 
ATOM   4549 C C      . VAL A 1 283 ? 13.944  -9.525  -11.367 1    19.485 ? 1291 VAL A C      1 ? 
ATOM   4550 O O      . VAL A 1 283 ? 14.578  -8.845  -12.176 1    16.838 ? 1291 VAL A O      1 ? 
ATOM   4551 C CB     . VAL A 1 283 ? 13.91   -9.032  -8.887  1    21.425 ? 1291 VAL A CB     1 ? 
ATOM   4552 C CG1    . VAL A 1 283 ? 15.39   -8.773  -9.089  1    19.933 ? 1291 VAL A CG1    1 ? 
ATOM   4553 C CG2    . VAL A 1 283 ? 13.314  -8.078  -7.853  1    20.114 ? 1291 VAL A CG2    1 ? 
ATOM   4554 H H      . VAL A 1 283 ? 11.551  -10.009 -9.314  1    21.597 ? 1291 VAL A H      1 ? 
ATOM   4555 H HA     . VAL A 1 283 ? 13.068  -7.812  -10.439 1    20.414 ? 1291 VAL A HA     1 c 
ATOM   4556 H HB     . VAL A 1 283 ? 13.771  -10.06  -8.545  1    20.679 ? 1291 VAL A HB     1 c 
ATOM   4557 H HG11   . VAL A 1 283 ? 15.827  -9.578  -9.683  1    20.32  ? 1291 VAL A HG11   1 c 
ATOM   4558 H HG12   . VAL A 1 283 ? 15.529  -7.823  -9.607  1    20.392 ? 1291 VAL A HG12   1 c 
ATOM   4559 H HG13   . VAL A 1 283 ? 15.888  -8.733  -8.118  1    20.345 ? 1291 VAL A HG13   1 c 
ATOM   4560 H HG21   . VAL A 1 283 ? 13.466  -7.047  -8.178  1    20.467 ? 1291 VAL A HG21   1 c 
ATOM   4561 H HG22   . VAL A 1 283 ? 12.245  -8.271  -7.749  1    20.465 ? 1291 VAL A HG22   1 c 
ATOM   4562 H HG23   . VAL A 1 283 ? 13.806  -8.231  -6.89   1    20.463 ? 1291 VAL A HG23   1 c 
ATOM   4563 N N      . ALA A 1 284 ? 13.909  -10.862 -11.44  1    19.51  ? 1292 ALA A N      1 ? 
ATOM   4564 C CA     . ALA A 1 284 ? 14.589  -11.559 -12.52  1    18.795 ? 1292 ALA A CA     1 ? 
ATOM   4565 C C      . ALA A 1 284 ? 14.055  -11.09  -13.883 1    18.9   ? 1292 ALA A C      1 ? 
ATOM   4566 O O      . ALA A 1 284 ? 14.845  -10.796 -14.794 1    18.417 ? 1292 ALA A O      1 ? 
ATOM   4567 C CB     . ALA A 1 284 ? 14.431  -13.052 -12.365 1    19.201 ? 1292 ALA A CB     1 ? 
ATOM   4568 H H      . ALA A 1 284 ? 13.379  -11.405 -10.74  1    18.613 ? 1292 ALA A H      1 ? 
ATOM   4569 H HA     . ALA A 1 284 ? 15.65   -11.308 -12.468 1    19.019 ? 1292 ALA A HA     1 c 
ATOM   4570 H HB1    . ALA A 1 284 ? 14.862  -13.37  -11.413 1    19.088 ? 1292 ALA A HB1    1 c 
ATOM   4571 H HB2    . ALA A 1 284 ? 13.371  -13.314 -12.386 1    19.088 ? 1292 ALA A HB2    1 c 
ATOM   4572 H HB3    . ALA A 1 284 ? 14.944  -13.563 -13.182 1    19.094 ? 1292 ALA A HB3    1 c 
ATOM   4573 N N      . GLU A 1 285 ? 12.721  -10.996 -14.05  1    18.304 ? 1293 GLU A N      1 ? 
ATOM   4574 C CA     . GLU A 1 285 ? 12.15   -10.562 -15.324 1    20.501 ? 1293 GLU A CA     1 ? 
ATOM   4575 C C      . GLU A 1 285 ? 12.656  -9.182  -15.72  1    19.556 ? 1293 GLU A C      1 ? 
ATOM   4576 O O      . GLU A 1 285 ? 12.955  -8.933  -16.888 1    18.674 ? 1293 GLU A O      1 ? 
ATOM   4577 C CB     . GLU A 1 285 ? 10.629  -10.551 -15.455 1    19.416 ? 1293 GLU A CB     1 ? 
ATOM   4578 H H      . GLU A 1 285 ? 12.067  -11.231 -13.285 1    19.777 ? 1293 GLU A H      1 ? 
ATOM   4579 N N      . ARG A 1 286 ? 12.711  -8.267  -14.746 1    22.952 ? 1294 ARG A N      1 ? 
ATOM   4580 C CA     . ARG A 1 286 ? 13.168  -6.912  -15.059 1    21.976 ? 1294 ARG A CA     1 ? 
ATOM   4581 C C      . ARG A 1 286 ? 14.612  -6.921  -15.542 1    19.967 ? 1294 ARG A C      1 ? 
ATOM   4582 O O      . ARG A 1 286 ? 14.994  -6.068  -16.349 1    21.678 ? 1294 ARG A O      1 ? 
ATOM   4583 C CB     . ARG A 1 286 ? 13.04   -5.993  -13.847 1    23.808 ? 1294 ARG A CB     1 ? 
ATOM   4584 C CG     . ARG A 1 286 ? 11.606  -5.668  -13.451 1    27.132 ? 1294 ARG A CG     1 ? 
ATOM   4585 C CD     . ARG A 1 286 ? 11.675  -4.775  -12.211 1    34.745 ? 1294 ARG A CD     1 ? 
ATOM   4586 N NE     . ARG A 1 286 ? 10.353  -4.701  -11.581 1    41.493 ? 1294 ARG A NE     1 ? 
ATOM   4587 C CZ     . ARG A 1 286 ? 10.044  -4.975  -10.314 1    47.413 ? 1294 ARG A CZ     1 ? 
ATOM   4588 N NH1    . ARG A 1 286 ? 10.972  -5.178  -9.393  1    45.952 ? 1294 ARG A NH1    1 ? 
ATOM   4589 N NH2    . ARG A 1 286 ? 8.777   -4.904  -9.945  1    52.214 ? 1294 ARG A NH2    1 ? 
ATOM   4590 H H      . ARG A 1 286 ? 12.398  -8.494  -13.784 1    22.889 ? 1294 ARG A H      1 ? 
ATOM   4591 H HA     . ARG A 1 286 ? 12.538  -6.518  -15.86  1    22.092 ? 1294 ARG A HA     1 c 
ATOM   4592 H HB2    . ARG A 1 286 ? 13.539  -6.464  -12.998 1    24.115 ? 1294 ARG A HB2    1 c 
ATOM   4593 H HB3    . ARG A 1 286 ? 13.563  -5.059  -14.061 1    24.083 ? 1294 ARG A HB3    1 c 
ATOM   4594 H HG2    . ARG A 1 286 ? 11.103  -5.137  -14.261 1    27.85  ? 1294 ARG A HG2    1 c 
ATOM   4595 H HG3    . ARG A 1 286 ? 11.063  -6.583  -13.217 1    27.928 ? 1294 ARG A HG3    1 c 
ATOM   4596 H HD2    . ARG A 1 286 ? 12.396  -5.186  -11.502 1    34.47  ? 1294 ARG A HD2    1 c 
ATOM   4597 H HD3    . ARG A 1 286 ? 12.001  -3.772  -12.492 1    34.33  ? 1294 ARG A HD3    1 c 
ATOM   4598 H HE     . ARG A 1 286 ? 9.584   -4.402  -12.168 1    41.324 ? 1294 ARG A HE     1 ? 
ATOM   4599 H HH11   . ARG A 1 286 ? 11.918  -4.835  -9.523  1    46.015 ? 1294 ARG A HH11   1 ? 
ATOM   4600 H HH12   . ARG A 1 286 ? 10.704  -5.586  -8.51   1    45.258 ? 1294 ARG A HH12   1 ? 
ATOM   4601 H HH21   . ARG A 1 286 ? 8.082   -4.596  -10.62  1    50.045 ? 1294 ARG A HH21   1 ? 
ATOM   4602 H HH22   . ARG A 1 286 ? 8.507   -5.147  -9.002  1    50.625 ? 1294 ARG A HH22   1 ? 
ATOM   4603 N N      . ARG A 1 287 ? 15.415  -7.859  -15.036 1    18.322 ? 1295 ARG A N      1 ? 
ATOM   4604 C CA     . ARG A 1 287 ? 16.801  -8      -15.439 1    17.652 ? 1295 ARG A CA     1 ? 
ATOM   4605 C C      . ARG A 1 287 ? 16.953  -8.82   -16.714 1    18.043 ? 1295 ARG A C      1 ? 
ATOM   4606 O O      . ARG A 1 287 ? 18.065  -8.957  -17.218 1    18.354 ? 1295 ARG A O      1 ? 
ATOM   4607 C CB     . ARG A 1 287 ? 17.609  -8.676  -14.321 1    19.227 ? 1295 ARG A CB     1 ? 
ATOM   4608 C CG     . ARG A 1 287 ? 17.616  -7.889  -13.014 1    18.615 ? 1295 ARG A CG     1 ? 
ATOM   4609 C CD     . ARG A 1 287 ? 18.182  -8.734  -11.877 1    19.732 ? 1295 ARG A CD     1 ? 
ATOM   4610 N NE     . ARG A 1 287 ? 19.574  -9.132  -12.101 1    21.395 ? 1295 ARG A NE     1 ? 
ATOM   4611 C CZ     . ARG A 1 287 ? 20.621  -8.381  -11.842 1    21.617 ? 1295 ARG A CZ     1 ? 
ATOM   4612 N NH1    . ARG A 1 287 ? 20.487  -7.151  -11.373 1    22.911 ? 1295 ARG A NH1    1 ? 
ATOM   4613 N NH2    . ARG A 1 287 ? 21.836  -8.874  -12.057 1    24.408 ? 1295 ARG A NH2    1 ? 
ATOM   4614 H H      . ARG A 1 287 ? 15.04   -8.578  -14.384 1    18.968 ? 1295 ARG A H      1 ? 
ATOM   4615 H HA     . ARG A 1 287 ? 17.211  -7.003  -15.615 1    18.135 ? 1295 ARG A HA     1 c 
ATOM   4616 H HB2    . ARG A 1 287 ? 17.192  -9.667  -14.133 1    18.748 ? 1295 ARG A HB2    1 c 
ATOM   4617 H HB3    . ARG A 1 287 ? 18.639  -8.807  -14.658 1    18.777 ? 1295 ARG A HB3    1 c 
ATOM   4618 H HG2    . ARG A 1 287 ? 18.225  -6.991  -13.133 1    18.998 ? 1295 ARG A HG2    1 c 
ATOM   4619 H HG3    . ARG A 1 287 ? 16.599  -7.587  -12.767 1    19.047 ? 1295 ARG A HG3    1 c 
ATOM   4620 H HD2    . ARG A 1 287 ? 18.116  -8.168  -10.946 1    19.891 ? 1295 ARG A HD2    1 c 
ATOM   4621 H HD3    . ARG A 1 287 ? 17.568  -9.631  -11.765 1    19.854 ? 1295 ARG A HD3    1 c 
ATOM   4622 H HE     . ARG A 1 287 ? 19.8    -10.038 -12.486 1    21.593 ? 1295 ARG A HE     1 ? 
ATOM   4623 H HH11   . ARG A 1 287 ? 19.596  -6.677  -11.174 1    23.799 ? 1295 ARG A HH11   1 ? 
ATOM   4624 H HH12   . ARG A 1 287 ? 21.323  -6.606  -11.308 1    22.545 ? 1295 ARG A HH12   1 ? 
ATOM   4625 H HH21   . ARG A 1 287 ? 21.848  -9.86   -12.303 1    23.725 ? 1295 ARG A HH21   1 ? 
ATOM   4626 H HH22   . ARG A 1 287 ? 22.709  -8.366  -11.899 1    22.779 ? 1295 ARG A HH22   1 ? 
ATOM   4627 N N      . GLY A 1 288 ? 15.857  -9.37   -17.24  1    18.958 ? 1296 GLY A N      1 ? 
ATOM   4628 C CA     . GLY A 1 288 ? 15.946  -10.206 -18.418 1    18.805 ? 1296 GLY A CA     1 ? 
ATOM   4629 C C      . GLY A 1 288 ? 16.408  -11.635 -18.124 1    19.384 ? 1296 GLY A C      1 ? 
ATOM   4630 O O      . GLY A 1 288 ? 16.919  -12.31  -19.015 1    20.741 ? 1296 GLY A O      1 ? 
ATOM   4631 H H      . GLY A 1 288 ? 14.921  -9.098  -16.889 1    18.711 ? 1296 GLY A H      1 ? 
ATOM   4632 H HA2    . GLY A 1 288 ? 14.968  -10.235 -18.904 1    18.975 ? 1296 GLY A HA2    1 c 
ATOM   4633 H HA3    . GLY A 1 288 ? 16.648  -9.741  -19.112 1    19.026 ? 1296 GLY A HA3    1 c 
ATOM   4634 N N      . GLU A 1 289 ? 16.211  -12.085 -16.891 1    21.766 ? 1297 GLU A N      1 ? 
ATOM   4635 C CA     . GLU A 1 289 ? 16.61   -13.418 -16.445 1    20.921 ? 1297 GLU A CA     1 ? 
ATOM   4636 C C      . GLU A 1 289 ? 15.361  -14.245 -16.126 1    17.868 ? 1297 GLU A C      1 ? 
ATOM   4637 O O      . GLU A 1 289 ? 14.301  -13.712 -15.834 1    20.023 ? 1297 GLU A O      1 ? 
ATOM   4638 C CB     . GLU A 1 289 ? 17.463  -13.294 -15.19  1    21.886 ? 1297 GLU A CB     1 ? 
ATOM   4639 C CG     . GLU A 1 289 ? 18.808  -12.608 -15.41  1    24.338 ? 1297 GLU A CG     1 ? 
ATOM   4640 C CD     . GLU A 1 289 ? 19.574  -12.459 -14.114 1    24.582 ? 1297 GLU A CD     1 ? 
ATOM   4641 O OE1    . GLU A 1 289 ? 19.858  -13.481 -13.445 1    29.972 ? 1297 GLU A OE1    1 ? 
ATOM   4642 O OE2    . GLU A 1 289 ? 19.887  -11.322 -13.766 1    28.779 ? 1297 GLU A OE2    1 ? 
ATOM   4643 H H      . GLU A 1 289 ? 15.681  -11.479 -16.227 1    20.127 ? 1297 GLU A H      1 ? 
ATOM   4644 H HA     . GLU A 1 289 ? 17.177  -13.906 -17.24  1    20.661 ? 1297 GLU A HA     1 c 
ATOM   4645 H HB2    . GLU A 1 289 ? 16.903  -12.733 -14.44  1    22.179 ? 1297 GLU A HB2    1 c 
ATOM   4646 H HB3    . GLU A 1 289 ? 17.643  -14.294 -14.79  1    22.179 ? 1297 GLU A HB3    1 c 
ATOM   4647 H HG2    . GLU A 1 289 ? 19.406  -13.195 -16.111 1    23.836 ? 1297 GLU A HG2    1 c 
ATOM   4648 H HG3    . GLU A 1 289 ? 18.645  -11.619 -15.843 1    23.836 ? 1297 GLU A HG3    1 c 
ATOM   4649 N N      . SER A 1 290 ? 15.526  -15.557 -16.151 1    17.977 ? 1298 SER A N      1 ? 
ATOM   4650 C CA     . SER A 1 290 ? 14.493  -16.499 -15.733 1    19.132 ? 1298 SER A CA     1 ? 
ATOM   4651 C C      . SER A 1 290 ? 14.737  -16.87  -14.276 1    16.878 ? 1298 SER A C      1 ? 
ATOM   4652 O O      . SER A 1 290 ? 15.764  -17.475 -13.964 1    17.86  ? 1298 SER A O      1 ? 
ATOM   4653 C CB     . SER A 1 290 ? 14.535  -17.745 -16.594 1    20.999 ? 1298 SER A CB     1 ? 
ATOM   4654 O OG     . SER A 1 290 ? 13.885  -18.816 -15.939 1    19.851 ? 1298 SER A OG     1 ? 
ATOM   4655 H H      . SER A 1 290 ? 16.43   -15.923 -16.491 1    17.831 ? 1298 SER A H      1 ? 
ATOM   4656 H HA     . SER A 1 290 ? 13.514  -16.025 -15.826 1    18.812 ? 1298 SER A HA     1 c 
ATOM   4657 H HB2    . SER A 1 290 ? 14.041  -17.545 -17.547 1    20.317 ? 1298 SER A HB2    1 c 
ATOM   4658 H HB3    . SER A 1 290 ? 15.574  -18.014 -16.793 1    20.317 ? 1298 SER A HB3    1 c 
ATOM   4659 H HG     . SER A 1 290 ? 12.941  -18.72  -16.112 1    21.587 ? 1298 SER A HG     1 ? 
ATOM   4660 N N      . TRP A 1 291 ? 13.785  -16.543 -13.398 1    19.529 ? 1299 TRP A N      1 ? 
ATOM   4661 C CA     . TRP A 1 291 ? 13.946  -16.928 -12.003 1    19.37  ? 1299 TRP A CA     1 ? 
ATOM   4662 C C      . TRP A 1 291 ? 13.926  -18.449 -11.836 1    19.346 ? 1299 TRP A C      1 ? 
ATOM   4663 O O      . TRP A 1 291 ? 14.671  -18.99  -11.021 1    20.187 ? 1299 TRP A O      1 ? 
ATOM   4664 C CB     . TRP A 1 291 ? 12.897  -16.252 -11.11  1    19.046 ? 1299 TRP A CB     1 ? 
ATOM   4665 C CG     . TRP A 1 291 ? 13      -16.729 -9.699  1    19.749 ? 1299 TRP A CG     1 ? 
ATOM   4666 C CD1    . TRP A 1 291 ? 12.068  -17.433 -9.008  1    20.838 ? 1299 TRP A CD1    1 ? 
ATOM   4667 C CD2    . TRP A 1 291 ? 14.126  -16.572 -8.828  1    19.659 ? 1299 TRP A CD2    1 ? 
ATOM   4668 N NE1    . TRP A 1 291 ? 12.538  -17.735 -7.751  1    23.471 ? 1299 TRP A NE1    1 ? 
ATOM   4669 C CE2    . TRP A 1 291 ? 13.793  -17.209 -7.613  1    21.477 ? 1299 TRP A CE2    1 ? 
ATOM   4670 C CE3    . TRP A 1 291 ? 15.366  -15.958 -8.949  1    19.91  ? 1299 TRP A CE3    1 ? 
ATOM   4671 C CZ2    . TRP A 1 291 ? 14.667  -17.249 -6.531  1    19.822 ? 1299 TRP A CZ2    1 ? 
ATOM   4672 C CZ3    . TRP A 1 291 ? 16.227  -15.983 -7.872  1    18.516 ? 1299 TRP A CZ3    1 ? 
ATOM   4673 C CH2    . TRP A 1 291 ? 15.882  -16.628 -6.682  1    20.637 ? 1299 TRP A CH2    1 ? 
ATOM   4674 H H      . TRP A 1 291 ? 12.9    -16.084 -13.676 1    19.187 ? 1299 TRP A H      1 ? 
ATOM   4675 H HA     . TRP A 1 291 ? 14.926  -16.573 -11.678 1    19.33  ? 1299 TRP A HA     1 c 
ATOM   4676 H HB2    . TRP A 1 291 ? 13.057  -15.172 -11.136 1    19.29  ? 1299 TRP A HB2    1 c 
ATOM   4677 H HB3    . TRP A 1 291 ? 11.902  -16.482 -11.496 1    19.274 ? 1299 TRP A HB3    1 c 
ATOM   4678 H HD1    . TRP A 1 291 ? 11.092  -17.723 -9.383  1    21.127 ? 1299 TRP A HD1    1 c 
ATOM   4679 H HE1    . TRP A 1 291 ? 12.004  -18.208 -7.025  1    24.219 ? 1299 TRP A HE1    1 ? 
ATOM   4680 H HE3    . TRP A 1 291 ? 15.643  -15.453 -9.868  1    19.565 ? 1299 TRP A HE3    1 c 
ATOM   4681 H HZ2    . TRP A 1 291 ? 14.395  -17.745 -5.605  1    20.323 ? 1299 TRP A HZ2    1 c 
ATOM   4682 H HZ3    . TRP A 1 291 ? 17.2    -15.509 -7.957  1    19.289 ? 1299 TRP A HZ3    1 c 
ATOM   4683 H HH2    . TRP A 1 291 ? 16.587  -16.637 -5.858  1    19.986 ? 1299 TRP A HH2    1 c 
ATOM   4684 N N      . ASP A 1 292 ? 13.096  -19.154 -12.603 1    21.275 ? 1300 ASP A N      1 ? 
ATOM   4685 C CA     . ASP A 1 292 ? 13.107  -20.615 -12.561 1    22.46  ? 1300 ASP A CA     1 ? 
ATOM   4686 C C      . ASP A 1 292 ? 14.521  -21.15  -12.791 1    20.687 ? 1300 ASP A C      1 ? 
ATOM   4687 O O      . ASP A 1 292 ? 15.022  -21.984 -12.033 1    22.08  ? 1300 ASP A O      1 ? 
ATOM   4688 C CB     . ASP A 1 292 ? 12.155  -21.202 -13.594 1    23.357 ? 1300 ASP A CB     1 ? 
ATOM   4689 C CG     . ASP A 1 292 ? 10.692  -20.951 -13.27  1    24.426 ? 1300 ASP A CG     1 ? 
ATOM   4690 O OD1    . ASP A 1 292 ? 10.371  -20.717 -12.078 1    23.797 ? 1300 ASP A OD1    1 ? 
ATOM   4691 O OD2    . ASP A 1 292 ? 9.879   -20.92  -14.227 1    24.929 ? 1300 ASP A OD2    1 ? 
ATOM   4692 H H      . ASP A 1 292 ? 12.474  -18.675 -13.272 1    19.507 ? 1300 ASP A H      1 ? 
ATOM   4693 H HA     . ASP A 1 292 ? 12.775  -20.931 -11.57  1    22.075 ? 1300 ASP A HA     1 c 
ATOM   4694 H HB2    . ASP A 1 292 ? 12.374  -20.765 -14.571 1    23.388 ? 1300 ASP A HB2    1 c 
ATOM   4695 H HB3    . ASP A 1 292 ? 12.316  -22.28  -13.658 1    23.388 ? 1300 ASP A HB3    1 c 
ATOM   4696 N N      . GLN A 1 293 ? 15.178  -20.689 -13.858 1    21.497 ? 1301 GLN A N      1 ? 
ATOM   4697 C CA     . GLN A 1 293 ? 16.56   -21.051 -14.204 1    22.387 ? 1301 GLN A CA     1 ? 
ATOM   4698 C C      . GLN A 1 293 ? 17.496  -20.739 -13.042 1    20.405 ? 1301 GLN A C      1 ? 
ATOM   4699 O O      . GLN A 1 293 ? 18.375  -21.539 -12.662 1    24.571 ? 1301 GLN A O      1 ? 
ATOM   4700 C CB     . GLN A 1 293 ? 17.054  -20.319 -15.466 1    26.879 ? 1301 GLN A CB     1 ? 
ATOM   4701 C CG     . GLN A 1 293 ? 18.546  -20.44  -15.841 1    32.9   ? 1301 GLN A CG     1 ? 
ATOM   4702 C CD     . GLN A 1 293 ? 19.523  -19.511 -15.117 1    39.668 ? 1301 GLN A CD     1 ? 
ATOM   4703 O OE1    . GLN A 1 293 ? 19.178  -18.415 -14.65  1    41.07  ? 1301 GLN A OE1    1 ? 
ATOM   4704 N NE2    . GLN A 1 293 ? 20.789  -19.923 -15.033 1    39.857 ? 1301 GLN A NE2    1 ? 
ATOM   4705 H H      . GLN A 1 293 ? 14.647  -20.11  -14.525 1    20.905 ? 1301 GLN A H      1 ? 
ATOM   4706 H HA     . GLN A 1 293 ? 16.592  -22.127 -14.393 1    22.569 ? 1301 GLN A HA     1 c 
ATOM   4707 H HB2    . GLN A 1 293 ? 16.462  -20.68  -16.309 1    26.983 ? 1301 GLN A HB2    1 c 
ATOM   4708 H HB3    . GLN A 1 293 ? 16.821  -19.26  -15.345 1    26.98  ? 1301 GLN A HB3    1 c 
ATOM   4709 H HG2    . GLN A 1 293 ? 18.867  -21.467 -15.658 1    32.773 ? 1301 GLN A HG2    1 c 
ATOM   4710 H HG3    . GLN A 1 293 ? 18.649  -20.259 -16.913 1    32.809 ? 1301 GLN A HG3    1 c 
ATOM   4711 N N      . LYS A 1 294 ? 17.36   -19.508 -12.518 1    18.534 ? 1302 LYS A N      1 ? 
ATOM   4712 C CA     . LYS A 1 294 ? 18.256  -19.051 -11.459 1    18.51  ? 1302 LYS A CA     1 ? 
ATOM   4713 C C      . LYS A 1 294 ? 18.083  -19.929 -10.208 1    14.908 ? 1302 LYS A C      1 ? 
ATOM   4714 O O      . LYS A 1 294 ? 19.062  -20.361 -9.594  1    14.37  ? 1302 LYS A O      1 ? 
ATOM   4715 C CB     . LYS A 1 294 ? 18.195  -17.61  -10.918 1    23.2   ? 1302 LYS A CB     1 ? 
ATOM   4716 C CG     . LYS A 1 294 ? 18.352  -16.444 -11.892 1    29.148 ? 1302 LYS A CG     1 ? 
ATOM   4717 C CD     . LYS A 1 294 ? 18.667  -15.106 -11.198 1    33.634 ? 1302 LYS A CD     1 ? 
ATOM   4718 C CE     . LYS A 1 294 ? 20.068  -14.998 -10.623 1    29.221 ? 1302 LYS A CE     1 ? 
ATOM   4719 N NZ     . LYS A 1 294 ? 21.074  -15.04  -11.703 1    26.433 ? 1302 LYS A NZ     1 ? 
ATOM   4720 H H      . LYS A 1 294 ? 16.588  -18.888 -12.811 1    18.643 ? 1302 LYS A H      1 ? 
ATOM   4721 H HA     . LYS A 1 294 ? 19.276  -19.197 -11.82  1    18.553 ? 1302 LYS A HA     1 c 
ATOM   4722 H HB2    . LYS A 1 294 ? 17.234  -17.49  -10.415 1    23.234 ? 1302 LYS A HB2    1 c 
ATOM   4723 H HB3    . LYS A 1 294 ? 18.969  -17.511 -10.155 1    23.286 ? 1302 LYS A HB3    1 c 
ATOM   4724 H HG2    . LYS A 1 294 ? 19.156  -16.681 -12.592 1    28.541 ? 1302 LYS A HG2    1 c 
ATOM   4725 H HG3    . LYS A 1 294 ? 17.429  -16.34  -12.465 1    28.501 ? 1302 LYS A HG3    1 c 
ATOM   4726 H HD2    . LYS A 1 294 ? 18.513  -14.296 -11.911 1    31.603 ? 1302 LYS A HD2    1 c 
ATOM   4727 H HD3    . LYS A 1 294 ? 17.947  -14.962 -10.389 1    31.61  ? 1302 LYS A HD3    1 c 
ATOM   4728 H HE2    . LYS A 1 294 ? 20.171  -14.06  -10.074 1    29.44  ? 1302 LYS A HE2    1 c 
ATOM   4729 H HE3    . LYS A 1 294 ? 20.25   -15.824 -9.931  1    29.393 ? 1302 LYS A HE3    1 c 
ATOM   4730 H HZ1    . LYS A 1 294 ? 21.109  -15.948 -12.143 1    24.878 ? 1302 LYS A HZ1    1 ? 
ATOM   4731 H HZ2    . LYS A 1 294 ? 20.803  -14.341 -12.4   1    26.734 ? 1302 LYS A HZ2    1 ? 
ATOM   4732 H HZ3    . LYS A 1 294 ? 22.015  -14.843 -11.344 1    25.391 ? 1302 LYS A HZ3    1 ? 
ATOM   4733 N N      . LEU A 1 295 ? 16.83   -20.162 -9.808  1    14.996 ? 1303 LEU A N      1 ? 
ATOM   4734 C CA     . LEU A 1 295 ? 16.578  -20.954 -8.61   1    15.004 ? 1303 LEU A CA     1 ? 
ATOM   4735 C C      . LEU A 1 295 ? 17.082  -22.386 -8.781  1    15.538 ? 1303 LEU A C      1 ? 
ATOM   4736 O O      . LEU A 1 295 ? 17.663  -22.962 -7.857  1    17.478 ? 1303 LEU A O      1 ? 
ATOM   4737 C CB     . LEU A 1 295 ? 15.098  -20.909 -8.257  1    14.881 ? 1303 LEU A CB     1 ? 
ATOM   4738 C CG     . LEU A 1 295 ? 14.71   -21.705 -7.005  1    15.22  ? 1303 LEU A CG     1 ? 
ATOM   4739 C CD1    . LEU A 1 295 ? 15.528  -21.27  -5.779  1    14.512 ? 1303 LEU A CD1    1 ? 
ATOM   4740 C CD2    . LEU A 1 295 ? 13.205  -21.575 -6.823  1    15.943 ? 1303 LEU A CD2    1 ? 
ATOM   4741 H H      . LEU A 1 295 ? 16.05   -19.702 -10.301 1    14.845 ? 1303 LEU A H      1 ? 
ATOM   4742 H HA     . LEU A 1 295 ? 17.144  -20.5   -7.794  1    15.069 ? 1303 LEU A HA     1 c 
ATOM   4743 H HB2    . LEU A 1 295 ? 14.813  -19.865 -8.107  1    14.981 ? 1303 LEU A HB2    1 c 
ATOM   4744 H HB3    . LEU A 1 295 ? 14.531  -21.298 -9.105  1    14.981 ? 1303 LEU A HB3    1 c 
ATOM   4745 H HG     . LEU A 1 295 ? 14.929  -22.758 -7.193  1    15.159 ? 1303 LEU A HG     1 c 
ATOM   4746 H HD11   . LEU A 1 295 ? 16.587  -21.465 -5.957  1    14.711 ? 1303 LEU A HD11   1 c 
ATOM   4747 H HD12   . LEU A 1 295 ? 15.38   -20.203 -5.601  1    14.708 ? 1303 LEU A HD12   1 c 
ATOM   4748 H HD13   . LEU A 1 295 ? 15.198  -21.833 -4.903  1    14.718 ? 1303 LEU A HD13   1 c 
ATOM   4749 H HD21   . LEU A 1 295 ? 12.695  -21.977 -7.7    1    15.732 ? 1303 LEU A HD21   1 c 
ATOM   4750 H HD22   . LEU A 1 295 ? 12.895  -22.132 -5.936  1    15.732 ? 1303 LEU A HD22   1 c 
ATOM   4751 H HD23   . LEU A 1 295 ? 12.942  -20.522 -6.7    1    15.713 ? 1303 LEU A HD23   1 c 
ATOM   4752 N N      . ALA A 1 296 ? 16.873  -22.976 -9.961  1    16.559 ? 1304 ALA A N      1 ? 
ATOM   4753 C CA     . ALA A 1 296 ? 17.399  -24.317 -10.208 1    15.785 ? 1304 ALA A CA     1 ? 
ATOM   4754 C C      . ALA A 1 296 ? 18.914  -24.343 -10.016 1    16.461 ? 1304 ALA A C      1 ? 
ATOM   4755 O O      . ALA A 1 296 ? 19.459  -25.285 -9.422  1    16.785 ? 1304 ALA A O      1 ? 
ATOM   4756 C CB     . ALA A 1 296 ? 17.011  -24.805 -11.598 1    15.711 ? 1304 ALA A CB     1 ? 
ATOM   4757 H H      . ALA A 1 296 ? 16.33   -22.48  -10.696 1    15.346 ? 1304 ALA A H      1 ? 
ATOM   4758 H HA     . ALA A 1 296 ? 16.959  -24.989 -9.468  1    16.034 ? 1304 ALA A HA     1 c 
ATOM   4759 H HB1    . ALA A 1 296 ? 15.923  -24.836 -11.686 1    15.735 ? 1304 ALA A HB1    1 c 
ATOM   4760 H HB2    . ALA A 1 296 ? 17.415  -24.125 -12.351 1    15.735 ? 1304 ALA A HB2    1 c 
ATOM   4761 H HB3    . ALA A 1 296 ? 17.415  -25.806 -11.762 1    15.746 ? 1304 ALA A HB3    1 c 
ATOM   4762 N N      . GLN A 1 297 ? 19.609  -23.309 -10.514 1    16.956 ? 1305 GLN A N      1 ? 
ATOM   4763 C CA     . GLN A 1 297 ? 21.064  -23.242 -10.376 1    18.732 ? 1305 GLN A CA     1 ? 
ATOM   4764 C C      . GLN A 1 297 ? 21.456  -23.075 -8.898  1    14.465 ? 1305 GLN A C      1 ? 
ATOM   4765 O O      . GLN A 1 297 ? 22.403  -23.708 -8.421  1    15.817 ? 1305 GLN A O      1 ? 
ATOM   4766 C CB     . GLN A 1 297 ? 21.66   -22.148 -11.277 1    21.883 ? 1305 GLN A CB     1 ? 
ATOM   4767 C CG     . GLN A 1 297 ? 23.15   -22.318 -11.586 1    27.695 ? 1305 GLN A CG     1 ? 
ATOM   4768 C CD     . GLN A 1 297 ? 23.547  -23.727 -12.049 1    35.933 ? 1305 GLN A CD     1 ? 
ATOM   4769 O OE1    . GLN A 1 297 ? 22.901  -24.351 -12.909 1    35.865 ? 1305 GLN A OE1    1 ? 
ATOM   4770 N NE2    . GLN A 1 297 ? 24.601  -24.307 -11.468 1    35.552 ? 1305 GLN A NE2    1 ? 
ATOM   4771 H H      . GLN A 1 297 ? 19.115  -22.594 -11.076 1    17.724 ? 1305 GLN A H      1 ? 
ATOM   4772 H HA     . GLN A 1 297 ? 21.465  -24.198 -10.715 1    18.123 ? 1305 GLN A HA     1 c 
ATOM   4773 H HB2    . GLN A 1 297 ? 21.106  -22.136 -12.218 1    22.271 ? 1305 GLN A HB2    1 c 
ATOM   4774 H HB3    . GLN A 1 297 ? 21.508  -21.181 -10.794 1    22.271 ? 1305 GLN A HB3    1 c 
ATOM   4775 H HG2    . GLN A 1 297 ? 23.435  -21.606 -12.363 1    27.853 ? 1305 GLN A HG2    1 c 
ATOM   4776 H HG3    . GLN A 1 297 ? 23.727  -22.074 -10.691 1    27.853 ? 1305 GLN A HG3    1 c 
ATOM   4777 H HE21   . GLN A 1 297 ? 25.035  -23.942 -10.622 1    33.048 ? 1305 GLN A HE21   1 ? 
ATOM   4778 H HE22   . GLN A 1 297 ? 24.937  -25.186 -11.866 1    33.874 ? 1305 GLN A HE22   1 ? 
ATOM   4779 N N      . LEU A 1 298 ? 20.758  -22.189 -8.18   1    16.048 ? 1306 LEU A N      1 ? 
ATOM   4780 C CA     . LEU A 1 298 ? 21.055  -21.972 -6.767  1    16.505 ? 1306 LEU A CA     1 ? 
ATOM   4781 C C      . LEU A 1 298 ? 20.887  -23.266 -5.971  1    16.656 ? 1306 LEU A C      1 ? 
ATOM   4782 O O      . LEU A 1 298 ? 21.695  -23.568 -5.086  1    17.045 ? 1306 LEU A O      1 ? 
ATOM   4783 C CB     . LEU A 1 298 ? 20.176  -20.865 -6.2    1    17.562 ? 1306 LEU A CB     1 ? 
ATOM   4784 C CG     . LEU A 1 298 ? 20.45   -19.458 -6.741  1    17.418 ? 1306 LEU A CG     1 ? 
ATOM   4785 C CD1    . LEU A 1 298 ? 19.331  -18.491 -6.302  1    17.125 ? 1306 LEU A CD1    1 ? 
ATOM   4786 C CD2    . LEU A 1 298 ? 21.803  -18.973 -6.268  1    16.992 ? 1306 LEU A CD2    1 ? 
ATOM   4787 H H      . LEU A 1 298 ? 19.964  -21.677 -8.605  1    15.739 ? 1306 LEU A H      1 ? 
ATOM   4788 H HA     . LEU A 1 298 ? 22.1    -21.665 -6.69   1    16.632 ? 1306 LEU A HA     1 c 
ATOM   4789 H HB2    . LEU A 1 298 ? 19.134  -21.118 -6.407  1    17.293 ? 1306 LEU A HB2    1 c 
ATOM   4790 H HB3    . LEU A 1 298 ? 20.305  -20.85  -5.116  1    17.293 ? 1306 LEU A HB3    1 c 
ATOM   4791 H HG     . LEU A 1 298 ? 20.463  -19.503 -7.83   1    17.292 ? 1306 LEU A HG     1 c 
ATOM   4792 H HD11   . LEU A 1 298 ? 19.537  -17.493 -6.693  1    17.207 ? 1306 LEU A HD11   1 c 
ATOM   4793 H HD12   . LEU A 1 298 ? 18.372  -18.842 -6.689  1    17.207 ? 1306 LEU A HD12   1 c 
ATOM   4794 H HD13   . LEU A 1 298 ? 19.289  -18.452 -5.211  1    17.215 ? 1306 LEU A HD13   1 c 
ATOM   4795 H HD21   . LEU A 1 298 ? 21.971  -17.955 -6.624  1    17.112 ? 1306 LEU A HD21   1 c 
ATOM   4796 H HD22   . LEU A 1 298 ? 21.834  -18.985 -5.176  1    17.112 ? 1306 LEU A HD22   1 c 
ATOM   4797 H HD23   . LEU A 1 298 ? 22.584  -19.628 -6.66   1    17.118 ? 1306 LEU A HD23   1 c 
ATOM   4798 N N      . LYS A 1 299 ? 19.831  -24.029 -6.264  1    16.875 ? 1307 LYS A N      1 ? 
ATOM   4799 C CA     . LYS A 1 299 ? 19.636  -25.301 -5.575  1    17.115 ? 1307 LYS A CA     1 ? 
ATOM   4800 C C      . LYS A 1 299 ? 20.718  -26.308 -5.959  1    15.801 ? 1307 LYS A C      1 ? 
ATOM   4801 O O      . LYS A 1 299 ? 21.253  -27.011 -5.097  1    14.573 ? 1307 LYS A O      1 ? 
ATOM   4802 C CB     . LYS A 1 299 ? 18.227  -25.854 -5.809  1    16.471 ? 1307 LYS A CB     1 ? 
ATOM   4803 C CG     . LYS A 1 299 ? 17.132  -25.023 -5.178  1    19.849 ? 1307 LYS A CG     1 ? 
ATOM   4804 C CD     . LYS A 1 299 ? 15.746  -25.609 -5.396  1    20.568 ? 1307 LYS A CD     1 ? 
ATOM   4805 C CE     . LYS A 1 299 ? 14.664  -24.875 -4.638  1    26.525 ? 1307 LYS A CE     1 ? 
ATOM   4806 N NZ     . LYS A 1 299 ? 13.547  -25.759 -4.19   1    28.381 ? 1307 LYS A NZ     1 ? 
ATOM   4807 H H      . LYS A 1 299 ? 19.126  -23.697 -6.943  1    16.813 ? 1307 LYS A H      1 ? 
ATOM   4808 H HA     . LYS A 1 299 ? 19.728  -25.111 -4.504  1    16.715 ? 1307 LYS A HA     1 c 
ATOM   4809 H HB2    . LYS A 1 299 ? 18.044  -25.912 -6.884  1    17.307 ? 1307 LYS A HB2    1 c 
ATOM   4810 H HB3    . LYS A 1 299 ? 18.173  -26.867 -5.406  1    17.307 ? 1307 LYS A HB3    1 c 
ATOM   4811 H HG2    . LYS A 1 299 ? 17.325  -24.947 -4.106  1    19.194 ? 1307 LYS A HG2    1 c 
ATOM   4812 H HG3    . LYS A 1 299 ? 17.167  -24.017 -5.599  1    19.186 ? 1307 LYS A HG3    1 c 
ATOM   4813 H HD2    . LYS A 1 299 ? 15.514  -25.58  -6.463  1    21.587 ? 1307 LYS A HD2    1 c 
ATOM   4814 H HD3    . LYS A 1 299 ? 15.751  -26.655 -5.083  1    21.587 ? 1307 LYS A HD3    1 c 
ATOM   4815 H HE2    . LYS A 1 299 ? 15.104  -24.399 -3.761  1    25.4   ? 1307 LYS A HE2    1 c 
ATOM   4816 H HE3    . LYS A 1 299 ? 14.253  -24.088 -5.274  1    25.453 ? 1307 LYS A HE3    1 c 
ATOM   4817 H HZ1    . LYS A 1 299 ? 13.341  -26.482 -4.883  1    27.603 ? 1307 LYS A HZ1    1 ? 
ATOM   4818 H HZ2    . LYS A 1 299 ? 13.921  -26.225 -3.366  1    27.618 ? 1307 LYS A HZ2    1 ? 
ATOM   4819 H HZ3    . LYS A 1 299 ? 12.691  -25.233 -3.929  1    29.098 ? 1307 LYS A HZ3    1 ? 
ATOM   4820 N N      . LYS A 1 300 ? 21.042  -26.397 -7.25   1    16.582 ? 1308 LYS A N      1 ? 
ATOM   4821 C CA     . LYS A 1 300 ? 22.088  -27.319 -7.676  1    18.908 ? 1308 LYS A CA     1 ? 
ATOM   4822 C C      . LYS A 1 300 ? 23.424  -26.987 -7      1    17.842 ? 1308 LYS A C      1 ? 
ATOM   4823 O O      . LYS A 1 300 ? 24.184  -27.883 -6.635  1    17.672 ? 1308 LYS A O      1 ? 
ATOM   4824 C CB     . LYS A 1 300 ? 22.225  -27.276 -9.197  1    22.268 ? 1308 LYS A CB     1 ? 
ATOM   4825 C CG     . LYS A 1 300 ? 23.268  -28.211 -9.757  1    26.888 ? 1308 LYS A CG     1 ? 
ATOM   4826 C CD     . LYS A 1 300 ? 23.217  -28.369 -11.272 1    33.143 ? 1308 LYS A CD     1 ? 
ATOM   4827 C CE     . LYS A 1 300 ? 24.442  -29.093 -11.754 1    40.871 ? 1308 LYS A CE     1 ? 
ATOM   4828 N NZ     . LYS A 1 300 ? 24.414  -29.08  -13.216 1    47.623 ? 1308 LYS A NZ     1 ? 
ATOM   4829 H H      . LYS A 1 300 ? 20.495  -25.878 -7.951  1    16.347 ? 1308 LYS A H      1 ? 
ATOM   4830 H HA     . LYS A 1 300 ? 21.793  -28.328 -7.382  1    18.795 ? 1308 LYS A HA     1 c 
ATOM   4831 H HB2    . LYS A 1 300 ? 21.26   -27.527 -9.644  1    22.406 ? 1308 LYS A HB2    1 c 
ATOM   4832 H HB3    . LYS A 1 300 ? 22.476  -26.257 -9.499  1    22.406 ? 1308 LYS A HB3    1 c 
ATOM   4833 H HG2    . LYS A 1 300 ? 24.255  -27.839 -9.473  1    26.932 ? 1308 LYS A HG2    1 c 
ATOM   4834 H HG3    . LYS A 1 300 ? 23.137  -29.192 -9.294  1    26.977 ? 1308 LYS A HG3    1 c 
ATOM   4835 H HD2    . LYS A 1 300 ? 22.327  -28.936 -11.552 1    33.176 ? 1308 LYS A HD2    1 c 
ATOM   4836 H HD3    . LYS A 1 300 ? 23.17   -27.384 -11.741 1    33.176 ? 1308 LYS A HD3    1 c 
ATOM   4837 H HE2    . LYS A 1 300 ? 25.346  -28.593 -11.399 1    40.422 ? 1308 LYS A HE2    1 c 
ATOM   4838 H HE3    . LYS A 1 300 ? 24.441  -30.125 -11.396 1    40.422 ? 1308 LYS A HE3    1 c 
ATOM   4839 H HZ1    . LYS A 1 300 ? 23.544  -29.528 -13.515 1    44.037 ? 1308 LYS A HZ1    1 ? 
ATOM   4840 H HZ2    . LYS A 1 300 ? 24.453  -28.113 -13.551 1    45.759 ? 1308 LYS A HZ2    1 ? 
ATOM   4841 H HZ3    . LYS A 1 300 ? 25.193  -29.579 -13.616 1    42.128 ? 1308 LYS A HZ3    1 ? 
ATOM   4842 N N      . ASN A 1 301 ? 23.705  -25.694 -6.838  1    17.242 ? 1309 ASN A N      1 ? 
ATOM   4843 C CA     . ASN A 1 301 ? 24.944  -25.22  -6.244  1    19.28  ? 1309 ASN A CA     1 ? 
ATOM   4844 C C      . ASN A 1 301 ? 24.916  -25.23  -4.713  1    18.36  ? 1309 ASN A C      1 ? 
ATOM   4845 O O      . ASN A 1 301 ? 25.903  -24.829 -4.088  1    18.058 ? 1309 ASN A O      1 ? 
ATOM   4846 C CB     . ASN A 1 301 ? 25.236  -23.779 -6.647  1    22.423 ? 1309 ASN A CB     1 ? 
ATOM   4847 C CG     . ASN A 1 301 ? 25.566  -23.61  -8.11   1    25.548 ? 1309 ASN A CG     1 ? 
ATOM   4848 O OD1    . ASN A 1 301 ? 25.807  -24.589 -8.828  1    24.014 ? 1309 ASN A OD1    1 ? 
ATOM   4849 N ND2    . ASN A 1 301 ? 25.624  -22.349 -8.552  1    27.574 ? 1309 ASN A ND2    1 ? 
ATOM   4850 H H      . ASN A 1 301 ? 22.998  -25.005 -7.159  1    18.29  ? 1309 ASN A H      1 ? 
ATOM   4851 H HA     . ASN A 1 301 ? 25.767  -25.845 -6.596  1    19.246 ? 1309 ASN A HA     1 c 
ATOM   4852 H HB2    . ASN A 1 301 ? 24.364  -23.164 -6.41   1    22.315 ? 1309 ASN A HB2    1 c 
ATOM   4853 H HB3    . ASN A 1 301 ? 26.074  -23.409 -6.054  1    22.401 ? 1309 ASN A HB3    1 c 
ATOM   4854 H HD21   . ASN A 1 301 ? 25.662  -22.219 -9.569  1    27.417 ? 1309 ASN A HD21   1 ? 
ATOM   4855 H HD22   . ASN A 1 301 ? 25.528  -21.546 -7.927  1    26.016 ? 1309 ASN A HD22   1 ? 
ATOM   4856 N N      . LYS A 1 302 ? 23.808  -25.659 -4.101  1    18.316 ? 1310 LYS A N      1 ? 
ATOM   4857 C CA     . LYS A 1 302 ? 23.681  -25.727 -2.643  1    19.523 ? 1310 LYS A CA     1 ? 
ATOM   4858 C C      . LYS A 1 302 ? 23.801  -24.356 -1.978  1    16.869 ? 1310 LYS A C      1 ? 
ATOM   4859 O O      . LYS A 1 302 ? 24.328  -24.224 -0.87   1    16.718 ? 1310 LYS A O      1 ? 
ATOM   4860 C CB     . LYS A 1 302 ? 24.609  -26.77  -2.027  1    24.847 ? 1310 LYS A CB     1 ? 
ATOM   4861 C CG     . LYS A 1 302 ? 23.992  -28.149 -2.236  1    31.23  ? 1310 LYS A CG     1 ? 
ATOM   4862 C CD     . LYS A 1 302 ? 24.899  -29.355 -2.455  1    41.205 ? 1310 LYS A CD     1 ? 
ATOM   4863 C CE     . LYS A 1 302 ? 24.002  -30.55  -2.187  1    52.488 ? 1310 LYS A CE     1 ? 
ATOM   4864 N NZ     . LYS A 1 302 ? 24.626  -31.843 -2.444  1    59.279 ? 1310 LYS A NZ     1 ? 
ATOM   4865 H H      . LYS A 1 302 ? 23.031  -25.968 -4.7    1    18.266 ? 1310 LYS A H      1 ? 
ATOM   4866 H HA     . LYS A 1 302 ? 22.672  -26.085 -2.435  1    19.753 ? 1310 LYS A HA     1 c 
ATOM   4867 H HB2    . LYS A 1 302 ? 25.592  -26.734 -2.5    1    24.712 ? 1310 LYS A HB2    1 c 
ATOM   4868 H HB3    . LYS A 1 302 ? 24.727  -26.588 -0.959  1    24.806 ? 1310 LYS A HB3    1 c 
ATOM   4869 H HG2    . LYS A 1 302 ? 23.368  -28.357 -1.367  1    31.733 ? 1310 LYS A HG2    1 c 
ATOM   4870 H HG3    . LYS A 1 302 ? 23.316  -28.079 -3.09   1    31.498 ? 1310 LYS A HG3    1 c 
ATOM   4871 H HD2    . LYS A 1 302 ? 25.266  -29.383 -3.483  1    40.917 ? 1310 LYS A HD2    1 c 
ATOM   4872 H HD3    . LYS A 1 302 ? 25.733  -29.346 -1.75   1    40.916 ? 1310 LYS A HD3    1 c 
ATOM   4873 H HE2    . LYS A 1 302 ? 23.697  -30.526 -1.14   1    51.099 ? 1310 LYS A HE2    1 c 
ATOM   4874 H HE3    . LYS A 1 302 ? 23.112  -30.47  -2.813  1    51.141 ? 1310 LYS A HE3    1 c 
ATOM   4875 H HZ1    . LYS A 1 302 ? 23.961  -32.564 -2.172  1    60.143 ? 1310 LYS A HZ1    1 ? 
ATOM   4876 H HZ2    . LYS A 1 302 ? 24.835  -31.92  -3.44   1    58.605 ? 1310 LYS A HZ2    1 ? 
ATOM   4877 H HZ3    . LYS A 1 302 ? 25.484  -31.941 -1.905  1    57.17  ? 1310 LYS A HZ3    1 ? 
ATOM   4878 N N      . GLN A 1 303 ? 23.247  -23.341 -2.647  1    16.334 ? 1311 GLN A N      1 ? 
ATOM   4879 C CA     . GLN A 1 303 ? 23.231  -21.983 -2.13   1    14.396 ? 1311 GLN A CA     1 ? 
ATOM   4880 C C      . GLN A 1 303 ? 21.912  -21.602 -1.463  1    14.898 ? 1311 GLN A C      1 ? 
ATOM   4881 O O      . GLN A 1 303 ? 21.83   -20.51  -0.895  1    13.89  ? 1311 GLN A O      1 ? 
ATOM   4882 C CB     . GLN A 1 303 ? 23.469  -20.985 -3.263  1    15.257 ? 1311 GLN A CB     1 ? 
ATOM   4883 C CG     . GLN A 1 303 ? 24.881  -20.982 -3.826  1    15.905 ? 1311 GLN A CG     1 ? 
ATOM   4884 C CD     . GLN A 1 303 ? 24.973  -20.152 -5.078  1    17.241 ? 1311 GLN A CD     1 ? 
ATOM   4885 O OE1    . GLN A 1 303 ? 24.949  -20.682 -6.189  1    17.611 ? 1311 GLN A OE1    1 ? 
ATOM   4886 N NE2    . GLN A 1 303 ? 25.026  -18.839 -4.909  1    18.266 ? 1311 GLN A NE2    1 ? 
ATOM   4887 H H      . GLN A 1 303 ? 22.847  -23.499 -3.595  1    16.412 ? 1311 GLN A H      1 ? 
ATOM   4888 H HA     . GLN A 1 303 ? 24.035  -21.882 -1.399  1    14.997 ? 1311 GLN A HA     1 c 
ATOM   4889 H HB2    . GLN A 1 303 ? 22.771  -21.209 -4.072  1    15.201 ? 1311 GLN A HB2    1 c 
ATOM   4890 H HB3    . GLN A 1 303 ? 23.237  -19.983 -2.898  1    15.193 ? 1311 GLN A HB3    1 c 
ATOM   4891 H HG2    . GLN A 1 303 ? 25.569  -20.581 -3.079  1    16.044 ? 1311 GLN A HG2    1 c 
ATOM   4892 H HG3    . GLN A 1 303 ? 25.186  -22.006 -4.051  1    16.044 ? 1311 GLN A HG3    1 c 
ATOM   4893 H HE21   . GLN A 1 303 ? 24.924  -18.442 -3.966  1    18.617 ? 1311 GLN A HE21   1 ? 
ATOM   4894 H HE22   . GLN A 1 303 ? 25.101  -18.228 -5.703  1    17.467 ? 1311 GLN A HE22   1 ? 
ATOM   4895 N N      . TRP A 1 304 ? 20.878  -22.454 -1.55   1    13.606 ? 1312 TRP A N      1 ? 
ATOM   4896 C CA     . TRP A 1 304 ? 19.513  -22.08  -1.207  1    14.613 ? 1312 TRP A CA     1 ? 
ATOM   4897 C C      . TRP A 1 304 ? 19.051  -22.882 0.003   1    14.993 ? 1312 TRP A C      1 ? 
ATOM   4898 O O      . TRP A 1 304 ? 18.949  -24.111 -0.075  1    18.116 ? 1312 TRP A O      1 ? 
ATOM   4899 C CB     . TRP A 1 304 ? 18.625  -22.366 -2.422  1    16.084 ? 1312 TRP A CB     1 ? 
ATOM   4900 C CG     . TRP A 1 304 ? 17.185  -21.98  -2.286  1    16.39  ? 1312 TRP A CG     1 ? 
ATOM   4901 C CD1    . TRP A 1 304 ? 16.164  -22.779 -1.896  1    15.867 ? 1312 TRP A CD1    1 ? 
ATOM   4902 C CD2    . TRP A 1 304 ? 16.615  -20.697 -2.591  1    15.61  ? 1312 TRP A CD2    1 ? 
ATOM   4903 N NE1    . TRP A 1 304 ? 14.983  -22.075 -1.926  1    16.713 ? 1312 TRP A NE1    1 ? 
ATOM   4904 C CE2    . TRP A 1 304 ? 15.232  -20.8   -2.343  1    16.82  ? 1312 TRP A CE2    1 ? 
ATOM   4905 C CE3    . TRP A 1 304 ? 17.13   -19.48  -3.054  1    16.663 ? 1312 TRP A CE3    1 ? 
ATOM   4906 C CZ2    . TRP A 1 304 ? 14.358  -19.733 -2.534  1    16.172 ? 1312 TRP A CZ2    1 ? 
ATOM   4907 C CZ3    . TRP A 1 304 ? 16.254  -18.42  -3.25   1    18.571 ? 1312 TRP A CZ3    1 ? 
ATOM   4908 C CH2    . TRP A 1 304 ? 14.889  -18.552 -2.994  1    17.376 ? 1312 TRP A CH2    1 ? 
ATOM   4909 H H      . TRP A 1 304 ? 21.042  -23.392 -1.931  1    15.19  ? 1312 TRP A H      1 ? 
ATOM   4910 H HA     . TRP A 1 304 ? 19.475  -21.013 -0.975  1    14.726 ? 1312 TRP A HA     1 c 
ATOM   4911 H HB2    . TRP A 1 304 ? 19.045  -21.843 -3.283  1    15.819 ? 1312 TRP A HB2    1 c 
ATOM   4912 H HB3    . TRP A 1 304 ? 18.679  -23.435 -2.641  1    15.819 ? 1312 TRP A HB3    1 c 
ATOM   4913 H HD1    . TRP A 1 304 ? 16.253  -23.818 -1.596  1    16.164 ? 1312 TRP A HD1    1 c 
ATOM   4914 H HE1    . TRP A 1 304 ? 14.089  -22.415 -1.681  1    17.242 ? 1312 TRP A HE1    1 ? 
ATOM   4915 H HE3    . TRP A 1 304 ? 18.191  -19.37  -3.252  1    16.827 ? 1312 TRP A HE3    1 c 
ATOM   4916 H HZ2    . TRP A 1 304 ? 13.295  -19.837 -2.344  1    16.58  ? 1312 TRP A HZ2    1 c 
ATOM   4917 H HZ3    . TRP A 1 304 ? 16.64   -17.468 -3.6    1    17.836 ? 1312 TRP A HZ3    1 c 
ATOM   4918 H HH2    . TRP A 1 304 ? 14.233  -17.702 -3.152  1    17.334 ? 1312 TRP A HH2    1 c 
ATOM   4919 N N      . HIS A 1 305 ? 18.754  -22.212 1.109   1    14.803 ? 1313 HIS A N      1 ? 
ATOM   4920 C CA     . HIS A 1 305 ? 18.516  -22.886 2.389   1    14.506 ? 1313 HIS A CA     1 ? 
ATOM   4921 C C      . HIS A 1 305 ? 17.227  -22.376 3.009   1    14.667 ? 1313 HIS A C      1 ? 
ATOM   4922 O O      . HIS A 1 305 ? 17.153  -21.215 3.399   1    15.253 ? 1313 HIS A O      1 ? 
ATOM   4923 C CB     . HIS A 1 305 ? 19.696  -22.66  3.335   1    14.817 ? 1313 HIS A CB     1 ? 
ATOM   4924 C CG     . HIS A 1 305 ? 21.021  -22.822 2.669   1    16.651 ? 1313 HIS A CG     1 ? 
ATOM   4925 N ND1    . HIS A 1 305 ? 21.522  -24.065 2.338   1    16.579 ? 1313 HIS A ND1    1 ? 
ATOM   4926 C CD2    . HIS A 1 305 ? 21.932  -21.911 2.243   1    15.586 ? 1313 HIS A CD2    1 ? 
ATOM   4927 C CE1    . HIS A 1 305 ? 22.706  -23.908 1.735   1    15.895 ? 1313 HIS A CE1    1 ? 
ATOM   4928 N NE2    . HIS A 1 305 ? 22.975  -22.616 1.674   1    15.46  ? 1313 HIS A NE2    1 ? 
ATOM   4929 H H      . HIS A 1 305 ? 18.777  -21.182 1.09    1    14.129 ? 1313 HIS A H      1 ? 
ATOM   4930 H HA     . HIS A 1 305 ? 18.41   -23.956 2.205   1    14.665 ? 1313 HIS A HA     1 c 
ATOM   4931 H HB2    . HIS A 1 305 ? 19.628  -21.651 3.748   1    15.128 ? 1313 HIS A HB2    1 c 
ATOM   4932 H HB3    . HIS A 1 305 ? 19.624  -23.369 4.161   1    15.136 ? 1313 HIS A HB3    1 c 
ATOM   4933 H HD1    . HIS A 1 305 ? 21.079  -24.949 2.538   1    16.945 ? 1313 HIS A HD1    1 ? 
ATOM   4934 H HD2    . HIS A 1 305 ? 21.862  -20.831 2.324   1    15.779 ? 1313 HIS A HD2    1 c 
ATOM   4935 H HE1    . HIS A 1 305 ? 23.343  -24.709 1.38    1    16.026 ? 1313 HIS A HE1    1 c 
ATOM   4936 H HE2    . HIS A 1 305 ? 23.78   -22.219 1.271   1    15.1   ? 1313 HIS A HE2    1 ? 
ATOM   4937 N N      . VAL A 1 306 ? 16.217  -23.245 3.106   1    13.875 ? 1314 VAL A N      1 ? 
ATOM   4938 C CA     . VAL A 1 306 ? 14.892  -22.831 3.563   1    16.178 ? 1314 VAL A CA     1 ? 
ATOM   4939 C C      . VAL A 1 306 ? 14.453  -23.717 4.716   1    14.794 ? 1314 VAL A C      1 ? 
ATOM   4940 O O      . VAL A 1 306 ? 14.437  -24.945 4.592   1    15.821 ? 1314 VAL A O      1 ? 
ATOM   4941 C CB     . VAL A 1 306 ? 13.85   -22.937 2.433   1    16.708 ? 1314 VAL A CB     1 ? 
ATOM   4942 C CG1    . VAL A 1 306 ? 12.467  -22.57  2.968   1    16.322 ? 1314 VAL A CG1    1 ? 
ATOM   4943 C CG2    . VAL A 1 306 ? 14.206  -22.04  1.254   1    19.213 ? 1314 VAL A CG2    1 ? 
ATOM   4944 H H      . VAL A 1 306 ? 16.357  -24.174 2.699   1    14.331 ? 1314 VAL A H      1 ? 
ATOM   4945 H HA     . VAL A 1 306 ? 14.94   -21.797 3.908   1    15.538 ? 1314 VAL A HA     1 c 
ATOM   4946 H HB     . VAL A 1 306 ? 13.832  -23.975 2.094   1    16.963 ? 1314 VAL A HB     1 c 
ATOM   4947 H HG11   . VAL A 1 306 ? 11.76   -22.515 2.138   1    16.424 ? 1314 VAL A HG11   1 c 
ATOM   4948 H HG12   . VAL A 1 306 ? 12.133  -23.33  3.678   1    16.416 ? 1314 VAL A HG12   1 c 
ATOM   4949 H HG13   . VAL A 1 306 ? 12.515  -21.6   3.467   1    16.418 ? 1314 VAL A HG13   1 c 
ATOM   4950 H HG21   . VAL A 1 306 ? 13.464  -22.166 0.462   1    18.44  ? 1314 VAL A HG21   1 c 
ATOM   4951 H HG22   . VAL A 1 306 ? 14.216  -20.998 1.579   1    18.382 ? 1314 VAL A HG22   1 c 
ATOM   4952 H HG23   . VAL A 1 306 ? 15.193  -22.312 0.873   1    18.367 ? 1314 VAL A HG23   1 c 
ATOM   4953 N N      . GLU A 1 307 ? 14.028  -23.104 5.812   1    16.171 ? 1315 GLU A N      1 ? 
ATOM   4954 C CA     . GLU A 1 307 ? 13.373  -23.824 6.9     1    17.097 ? 1315 GLU A CA     1 ? 
ATOM   4955 C C      . GLU A 1 307 ? 12.214  -22.963 7.393   1    16.396 ? 1315 GLU A C      1 ? 
ATOM   4956 O O      . GLU A 1 307 ? 12.408  -22.021 8.169   1    17.32  ? 1315 GLU A O      1 ? 
ATOM   4957 C CB     . GLU A 1 307 ? 14.33   -24.174 8.03    1    20.357 ? 1315 GLU A CB     1 ? 
ATOM   4958 C CG     . GLU A 1 307 ? 13.648  -25.029 9.094   1    23.376 ? 1315 GLU A CG     1 ? 
ATOM   4959 C CD     . GLU A 1 307 ? 14.581  -26.066 9.717   1    28.563 ? 1315 GLU A CD     1 ? 
ATOM   4960 O OE1    . GLU A 1 307 ? 15.36   -25.663 10.586  1    28.957 ? 1315 GLU A OE1    1 ? 
ATOM   4961 O OE2    . GLU A 1 307 ? 14.506  -27.282 9.402   1    29.192 ? 1315 GLU A OE2    1 ? 
ATOM   4962 H H      . GLU A 1 307 ? 14.24   -22.107 5.95    1    15.743 ? 1315 GLU A H      1 ? 
ATOM   4963 H HA     . GLU A 1 307 ? 12.963  -24.752 6.497   1    17.307 ? 1315 GLU A HA     1 c 
ATOM   4964 H HB2    . GLU A 1 307 ? 15.186  -24.713 7.618   1    20.188 ? 1315 GLU A HB2    1 c 
ATOM   4965 H HB3    . GLU A 1 307 ? 14.701  -23.251 8.481   1    20.188 ? 1315 GLU A HB3    1 c 
ATOM   4966 H HG2    . GLU A 1 307 ? 13.267  -24.38  9.886   1    23.702 ? 1315 GLU A HG2    1 c 
ATOM   4967 H HG3    . GLU A 1 307 ? 12.798  -25.548 8.647   1    23.702 ? 1315 GLU A HG3    1 c 
ATOM   4968 N N      . VAL A 1 308 ? 11.008  -23.274 6.913   1    17.013 ? 1316 VAL A N      1 ? 
ATOM   4969 C CA     . VAL A 1 308 ? 9.829   -22.499 7.25    1    17.716 ? 1316 VAL A CA     1 ? 
ATOM   4970 C C      . VAL A 1 308 ? 8.771   -23.44  7.806   1    17.368 ? 1316 VAL A C      1 ? 
ATOM   4971 O O      . VAL A 1 308 ? 8.806   -24.645 7.576   1    18.386 ? 1316 VAL A O      1 ? 
ATOM   4972 C CB     . VAL A 1 308 ? 9.303   -21.67  6.059   1    18.386 ? 1316 VAL A CB     1 ? 
ATOM   4973 C CG1    . VAL A 1 308 ? 10.334  -20.608 5.678   1    15.808 ? 1316 VAL A CG1    1 ? 
ATOM   4974 C CG2    . VAL A 1 308 ? 8.96    -22.557 4.86    1    17.32  ? 1316 VAL A CG2    1 ? 
ATOM   4975 H H      . VAL A 1 308 ? 10.943  -24.046 6.218   1    16.786 ? 1316 VAL A H      1 ? 
ATOM   4976 H HA     . VAL A 1 308 ? 10.105  -21.804 8.043   1    17.597 ? 1316 VAL A HA     1 c 
ATOM   4977 H HB     . VAL A 1 308 ? 8.397   -21.164 6.392   1    17.632 ? 1316 VAL A HB     1 c 
ATOM   4978 H HG11   . VAL A 1 308 ? 11.271  -21.093 5.397   1    16.493 ? 1316 VAL A HG11   1 c 
ATOM   4979 H HG12   . VAL A 1 308 ? 9.961   -20.023 4.835   1    16.493 ? 1316 VAL A HG12   1 c 
ATOM   4980 H HG13   . VAL A 1 308 ? 10.508  -19.947 6.53    1    16.518 ? 1316 VAL A HG13   1 c 
ATOM   4981 H HG21   . VAL A 1 308 ? 9.846   -23.12  4.557   1    17.605 ? 1316 VAL A HG21   1 c 
ATOM   4982 H HG22   . VAL A 1 308 ? 8.164   -23.252 5.134   1    17.607 ? 1316 VAL A HG22   1 c 
ATOM   4983 H HG23   . VAL A 1 308 ? 8.625   -21.933 4.029   1    17.609 ? 1316 VAL A HG23   1 c 
ATOM   4984 N N      . TYR A 1 309 ? 7.819   -22.87  8.538   1    17.864 ? 1317 TYR A N      1 ? 
ATOM   4985 C CA     . TYR A 1 309 ? 6.983   -23.701 9.392   1    18.475 ? 1317 TYR A CA     1 ? 
ATOM   4986 C C      . TYR A 1 309 ? 5.64    -23.047 9.714   1    19.816 ? 1317 TYR A C      1 ? 
ATOM   4987 O O      . TYR A 1 309 ? 5.276   -22.016 9.152   1    21.908 ? 1317 TYR A O      1 ? 
ATOM   4988 C CB     . TYR A 1 309 ? 7.739   -24.038 10.685  1    15.946 ? 1317 TYR A CB     1 ? 
ATOM   4989 C CG     . TYR A 1 309 ? 8.433   -22.845 11.303  1    15.568 ? 1317 TYR A CG     1 ? 
ATOM   4990 C CD1    . TYR A 1 309 ? 7.715   -21.896 12.012  1    14.479 ? 1317 TYR A CD1    1 ? 
ATOM   4991 C CD2    . TYR A 1 309 ? 9.802   -22.671 11.173  1    15.589 ? 1317 TYR A CD2    1 ? 
ATOM   4992 C CE1    . TYR A 1 309 ? 8.338   -20.797 12.577  1    14.525 ? 1317 TYR A CE1    1 ? 
ATOM   4993 C CE2    . TYR A 1 309 ? 10.44   -21.58  11.74   1    14.354 ? 1317 TYR A CE2    1 ? 
ATOM   4994 C CZ     . TYR A 1 309 ? 9.703   -20.64  12.439  1    14.258 ? 1317 TYR A CZ     1 ? 
ATOM   4995 O OH     . TYR A 1 309 ? 10.305  -19.545 13.001  1    14.229 ? 1317 TYR A OH     1 ? 
ATOM   4996 O OXT    . TYR A 1 309 ? 4.919   -23.627 10.568  1    26.991 ? 1317 TYR A OXT    1 ? 
ATOM   4997 H H      . TYR A 1 309 ? 7.735   -21.84  8.582   1    17.554 ? 1317 TYR A H      1 ? 
ATOM   4998 H HA     . TYR A 1 309 ? 6.783   -24.635 8.864   1    18.2   ? 1317 TYR A HA     1 c 
ATOM   4999 H HB2    . TYR A 1 309 ? 7.034   -24.454 11.407  1    16.431 ? 1317 TYR A HB2    1 c 
ATOM   5000 H HB3    . TYR A 1 309 ? 8.484   -24.805 10.462  1    16.388 ? 1317 TYR A HB3    1 c 
ATOM   5001 H HD1    . TYR A 1 309 ? 6.641   -22.012 12.122  1    14.751 ? 1317 TYR A HD1    1 c 
ATOM   5002 H HD2    . TYR A 1 309 ? 10.385  -23.404 10.624  1    15.288 ? 1317 TYR A HD2    1 c 
ATOM   5003 H HE1    . TYR A 1 309 ? 7.759   -20.063 13.127  1    14.469 ? 1317 TYR A HE1    1 c 
ATOM   5004 H HE2    . TYR A 1 309 ? 11.512  -21.456 11.627  1    14.601 ? 1317 TYR A HE2    1 c 
ATOM   5005 H HH     . TYR A 1 309 ? 11.248  -19.695 12.963  1    14.213 ? 1317 TYR A HH     1 ? 
HETATM 5006 O O1     . MES B 2 .   ? 5.526   -24.618 -2.62   1    35.574 ? 1401 MES A O1     1 ? 
HETATM 5007 C C2     . MES B 2 .   ? 5.887   -24.764 -1.25   1    33.76  ? 1401 MES A C2     1 ? 
HETATM 5008 C C3     . MES B 2 .   ? 7.318   -25.222 -1.118  1    35.126 ? 1401 MES A C3     1 ? 
HETATM 5009 N N4     . MES B 2 .   ? 7.685   -26.056 -2.307  1    39.635 ? 1401 MES A N4     1 ? 
HETATM 5010 C C5     . MES B 2 .   ? 6.49    -26.83  -2.797  1    35.064 ? 1401 MES A C5     1 ? 
HETATM 5011 C C6     . MES B 2 .   ? 5.391   -25.89  -3.24   1    33.001 ? 1401 MES A C6     1 ? 
HETATM 5012 C C7     . MES B 2 .   ? 8.875   -26.945 -2.03   1    43.381 ? 1401 MES A C7     1 ? 
HETATM 5013 C C8     . MES B 2 .   ? 10.185  -26.438 -2.621  1    45.362 ? 1401 MES A C8     1 ? 
HETATM 5014 S S      . MES B 2 .   ? 11.313  -27.753 -3.034  0.97 50.121 ? 1401 MES A S      1 ? 
HETATM 5015 O O1S    . MES B 2 .   ? 11.288  -27.908 -4.468  1    48.053 ? 1401 MES A O1S    1 ? 
HETATM 5016 O O2S    . MES B 2 .   ? 10.825  -28.907 -2.342  1    54.592 ? 1401 MES A O2S    1 ? 
HETATM 5017 O O3S    . MES B 2 .   ? 12.598  -27.341 -2.545  1    59.89  ? 1401 MES A O3S    1 ? 
HETATM 5018 H H21    . MES B 2 .   ? 5.227   -25.491 -0.778  1    34.455 ? 1401 MES A H21    1 c 
HETATM 5019 H H22    . MES B 2 .   ? 5.765   -23.811 -0.741  1    34.397 ? 1401 MES A H22    1 c 
HETATM 5020 H H31    . MES B 2 .   ? 7.439   -25.816 -0.214  1    35.827 ? 1401 MES A H31    1 c 
HETATM 5021 H H32    . MES B 2 .   ? 7.984   -24.362 -1.066  1    35.782 ? 1401 MES A H32    1 c 
HETATM 5022 H H51    . MES B 2 .   ? 6.129   -27.468 -1.991  1    35.557 ? 1401 MES A H51    1 c 
HETATM 5023 H H52    . MES B 2 .   ? 6.795   -27.462 -3.63   1    35.556 ? 1401 MES A H52    1 c 
HETATM 5024 H H61    . MES B 2 .   ? 5.431   -25.769 -4.321  1    34.022 ? 1401 MES A H61    1 c 
HETATM 5025 H H62    . MES B 2 .   ? 4.423   -26.315 -2.98   1    34.023 ? 1401 MES A H62    1 c 
HETATM 5026 H H71    . MES B 2 .   ? 8.637   -27.929 -2.431  1    42.904 ? 1401 MES A H71    1 c 
HETATM 5027 H H72    . MES B 2 .   ? 8.962   -27.041 -0.948  1    42.799 ? 1401 MES A H72    1 c 
HETATM 5028 H H81    . MES B 2 .   ? 10.695  -25.783 -1.916  1    45.769 ? 1401 MES A H81    1 c 
HETATM 5029 H H82    . MES B 2 .   ? 10.007  -25.866 -3.527  1    45.767 ? 1401 MES A H82    1 c 
HETATM 5030 O O1     . MES C 2 .   ? 5.154   -11.132 8.322   1    58.69  ? 1402 MES A O1     1 ? 
HETATM 5031 C C2     . MES C 2 .   ? 4.994   -12.538 8.496   1    64.466 ? 1402 MES A C2     1 ? 
HETATM 5032 C C3     . MES C 2 .   ? 4.627   -12.895 9.918   1    60.343 ? 1402 MES A C3     1 ? 
HETATM 5033 N N4     . MES C 2 .   ? 5.479   -12.119 10.88   1    56.472 ? 1402 MES A N4     1 ? 
HETATM 5034 C C5     . MES C 2 .   ? 5.256   -10.645 10.697  1    53.996 ? 1402 MES A C5     1 ? 
HETATM 5035 C C6     . MES C 2 .   ? 4.556   -10.391 9.382   1    53.236 ? 1402 MES A C6     1 ? 
HETATM 5036 C C7     . MES C 2 .   ? 5.331   -12.588 12.304  1    48.101 ? 1402 MES A C7     1 ? 
HETATM 5037 C C8     . MES C 2 .   ? 4.923   -14.05  12.405  1    36.593 ? 1402 MES A C8     1 ? 
HETATM 5038 S S      . MES C 2 .   ? 5.676   -14.973 13.726  1    30.827 ? 1402 MES A S      1 ? 
HETATM 5039 O O1S    . MES C 2 .   ? 5.852   -14.035 14.785  1    29.196 ? 1402 MES A O1S    1 ? 
HETATM 5040 O O2S    . MES C 2 .   ? 6.924   -15.501 13.262  1    24.607 ? 1402 MES A O2S    1 ? 
HETATM 5041 O O3S    . MES C 2 .   ? 4.737   -16.02  14.024  1    32.287 ? 1402 MES A O3S    1 ? 
HETATM 5042 P PA     . FDA D 3 .   ? -0.463  -26.476 19.1    1    17.919 ? 1403 FDA A PA     1 ? 
HETATM 5043 O O1A    . FDA D 3 .   ? 0.221   -27.49  18.258  1    19.613 ? 1403 FDA A O1A    1 ? 
HETATM 5044 O O2A    . FDA D 3 .   ? -0.926  -26.882 20.451  1    18.355 ? 1403 FDA A O2A    1 ? 
HETATM 5045 O O5B    . FDA D 3 .   ? -1.662  -25.872 18.236  1    17.903 ? 1403 FDA A O5B    1 ? 
HETATM 5046 C C5B    . FDA D 3 .   ? -1.42   -25.516 16.845  1    18.966 ? 1403 FDA A C5B    1 ? 
HETATM 5047 C C4B    . FDA D 3 .   ? -2.233  -24.302 16.474  1    18.472 ? 1403 FDA A C4B    1 ? 
HETATM 5048 O O4B    . FDA D 3 .   ? -3.626  -24.682 16.467  1    21.064 ? 1403 FDA A O4B    1 ? 
HETATM 5049 C C3B    . FDA D 3 .   ? -2.123  -23.088 17.408  1    19.97  ? 1403 FDA A C3B    1 ? 
HETATM 5050 O O3B    . FDA D 3 .   ? -2.157  -21.894 16.655  1    18.571 ? 1403 FDA A O3B    1 ? 
HETATM 5051 C C2B    . FDA D 3 .   ? -3.432  -23.121 18.224  1    21.813 ? 1403 FDA A C2B    1 ? 
HETATM 5052 O O2B    . FDA D 3 .   ? -3.739  -21.763 18.563  1    21.38  ? 1403 FDA A O2B    1 ? 
HETATM 5053 C C1B    . FDA D 3 .   ? -4.392  -23.753 17.209  1    21.711 ? 1403 FDA A C1B    1 ? 
HETATM 5054 N N9A    . FDA D 3 .   ? -5.58   -24.437 17.726  1    24.685 ? 1403 FDA A N9A    1 ? 
HETATM 5055 C C8A    . FDA D 3 .   ? -5.656  -25.462 18.638  1    28.639 ? 1403 FDA A C8A    1 ? 
HETATM 5056 N N7A    . FDA D 3 .   ? -6.876  -25.909 18.843  1    27.482 ? 1403 FDA A N7A    1 ? 
HETATM 5057 C C5A    . FDA D 3 .   ? -7.661  -25.122 18.006  1    26.645 ? 1403 FDA A C5A    1 ? 
HETATM 5058 C C6A    . FDA D 3 .   ? -9.049  -25.092 17.747  1    27.262 ? 1403 FDA A C6A    1 ? 
HETATM 5059 N N6A    . FDA D 3 .   ? -9.897  -25.981 18.212  1    28.56  ? 1403 FDA A N6A    1 ? 
HETATM 5060 N N1A    . FDA D 3 .   ? -9.516  -24.174 16.872  1    25.827 ? 1403 FDA A N1A    1 ? 
HETATM 5061 C C2A    . FDA D 3 .   ? -8.647  -23.35  16.285  1    26.253 ? 1403 FDA A C2A    1 ? 
HETATM 5062 N N3A    . FDA D 3 .   ? -7.314  -23.29  16.44   1    25.148 ? 1403 FDA A N3A    1 ? 
HETATM 5063 C C4A    . FDA D 3 .   ? -6.879  -24.208 17.315  1    26.157 ? 1403 FDA A C4A    1 ? 
HETATM 5064 N N1     . FDA D 3 .   ? 7.755   -21.764 16.297  1    13.904 ? 1403 FDA A N1     1 ? 
HETATM 5065 C C2     . FDA D 3 .   ? 8.186   -20.702 17.023  1    13.251 ? 1403 FDA A C2     1 ? 
HETATM 5066 O O2     . FDA D 3 .   ? 7.417   -19.913 17.541  1    14.765 ? 1403 FDA A O2     1 ? 
HETATM 5067 N N3     . FDA D 3 .   ? 9.533   -20.497 17.03   1    15.078 ? 1403 FDA A N3     1 ? 
HETATM 5068 C C4     . FDA D 3 .   ? 10.493  -21.213 16.31   1    14.609 ? 1403 FDA A C4     1 ? 
HETATM 5069 O O4     . FDA D 3 .   ? 11.687  -20.907 16.385  1    15.714 ? 1403 FDA A O4     1 ? 
HETATM 5070 C C4X    . FDA D 3 .   ? 9.982   -22.287 15.593  1    14.603 ? 1403 FDA A C4X    1 ? 
HETATM 5071 N N5     . FDA D 3 .   ? 10.84   -23.076 14.874  1    15.157 ? 1403 FDA A N5     1 ? 
HETATM 5072 C C5X    . FDA D 3 .   ? 10.403  -24.242 14.242  1    16.829 ? 1403 FDA A C5X    1 ? 
HETATM 5073 C C6     . FDA D 3 .   ? 11.287  -24.988 13.483  1    18.529 ? 1403 FDA A C6     1 ? 
HETATM 5074 C C7     . FDA D 3 .   ? 10.835  -26.065 12.73   1    17.752 ? 1403 FDA A C7     1 ? 
HETATM 5075 C C7M    . FDA D 3 .   ? 11.792  -26.784 11.818  1    19.401 ? 1403 FDA A C7M    1 ? 
HETATM 5076 C C8     . FDA D 3 .   ? 9.478   -26.411 12.756  1    19.381 ? 1403 FDA A C8     1 ? 
HETATM 5077 C C8M    . FDA D 3 .   ? 8.964   -27.532 11.895  1    20.384 ? 1403 FDA A C8M    1 ? 
HETATM 5078 C C9     . FDA D 3 .   ? 8.591   -25.67  13.522  1    17.397 ? 1403 FDA A C9     1 ? 
HETATM 5079 C C9A    . FDA D 3 .   ? 9.04    -24.583 14.267  1    17.001 ? 1403 FDA A C9A    1 ? 
HETATM 5080 N N10    . FDA D 3 .   ? 8.128   -23.735 14.993  1    15.241 ? 1403 FDA A N10    1 ? 
HETATM 5081 C C10    . FDA D 3 .   ? 8.626   -22.595 15.611  1    13.968 ? 1403 FDA A C10    1 ? 
HETATM 5082 C "C1'"  . FDA D 3 .   ? 6.711   -24.133 15.173  1    14.456 ? 1403 FDA A "C1'"  1 ? 
HETATM 5083 C "C2'"  . FDA D 3 .   ? 6.553   -24.893 16.493  1    13.164 ? 1403 FDA A "C2'"  1 ? 
HETATM 5084 O "O2'"  . FDA D 3 .   ? 7.102   -26.207 16.416  1    14.066 ? 1403 FDA A "O2'"  1 ? 
HETATM 5085 C "C3'"  . FDA D 3 .   ? 5.063   -25.049 16.842  1    13.861 ? 1403 FDA A "C3'"  1 ? 
HETATM 5086 O "O3'"  . FDA D 3 .   ? 4.315   -25.588 15.749  1    14.303 ? 1403 FDA A "O3'"  1 ? 
HETATM 5087 C "C4'"  . FDA D 3 .   ? 4.387   -23.753 17.283  1    13.059 ? 1403 FDA A "C4'"  1 ? 
HETATM 5088 O "O4'"  . FDA D 3 .   ? 5.123   -23.211 18.377  1    12.931 ? 1403 FDA A "O4'"  1 ? 
HETATM 5089 C "C5'"  . FDA D 3 .   ? 2.958   -24.001 17.735  1    13.034 ? 1403 FDA A "C5'"  1 ? 
HETATM 5090 O "O5'"  . FDA D 3 .   ? 2.939   -25.077 18.7    1    12.565 ? 1403 FDA A "O5'"  1 ? 
HETATM 5091 P P      . FDA D 3 .   ? 1.918   -25.043 19.966  1    13.919 ? 1403 FDA A P      1 ? 
HETATM 5092 O O1P    . FDA D 3 .   ? 2.204   -26.277 20.733  1    13.05  ? 1403 FDA A O1P    1 ? 
HETATM 5093 O O2P    . FDA D 3 .   ? 1.917   -23.747 20.681  1    12.729 ? 1403 FDA A O2P    1 ? 
HETATM 5094 O O3P    . FDA D 3 .   ? 0.496   -25.202 19.233  1    15.084 ? 1403 FDA A O3P    1 ? 
HETATM 5095 H H51A   . FDA D 3 .   ? -1.716  -26.356 16.212  1    18.612 ? 1403 FDA A H51A   1 c 
HETATM 5096 H H52A   . FDA D 3 .   ? -0.356  -25.36  16.646  1    18.617 ? 1403 FDA A H52A   1 c 
HETATM 5097 H H4B    . FDA D 3 .   ? -1.98   -24.002 15.454  1    19.294 ? 1403 FDA A H4B    1 c 
HETATM 5098 H H3B    . FDA D 3 .   ? -1.207  -23.035 18.001  1    19.707 ? 1403 FDA A H3B    1 c 
HETATM 5099 H HO3A   . FDA D 3 .   ? -1.213  -21.794 16.596  1    20.849 ? 1403 FDA A HO3A   1 ? 
HETATM 5100 H H2B    . FDA D 3 .   ? -3.366  -23.721 19.135  1    21.391 ? 1403 FDA A H2B    1 c 
HETATM 5101 H HO2A   . FDA D 3 .   ? -4.306  -21.743 19.359  1    22.989 ? 1403 FDA A HO2A   1 ? 
HETATM 5102 H H1B    . FDA D 3 .   ? -4.739  -22.997 16.5    1    22.138 ? 1403 FDA A H1B    1 c 
HETATM 5103 H H8A    . FDA D 3 .   ? -4.774  -25.848 19.128  1    27.481 ? 1403 FDA A H8A    1 c 
HETATM 5104 H H61A   . FDA D 3 .   ? -10.86  -25.832 17.969  1    28.89  ? 1403 FDA A H61A   1 ? 
HETATM 5105 H H62A   . FDA D 3 .   ? -9.529  -26.745 18.782  1    29.518 ? 1403 FDA A H62A   1 ? 
HETATM 5106 H H2A    . FDA D 3 .   ? -9.072  -22.635 15.591  1    25.9   ? 1403 FDA A H2A    1 c 
HETATM 5107 H HN1    . FDA D 3 .   ? 6.76    -21.83  16.233  1    13.601 ? 1403 FDA A HN1    1 ? 
HETATM 5108 H HN3    . FDA D 3 .   ? 9.794   -19.771 17.643  1    14.774 ? 1403 FDA A HN3    1 ? 
HETATM 5109 H HN5    . FDA D 3 .   ? 11.75   -22.72  14.693  1    16.129 ? 1403 FDA A HN5    1 ? 
HETATM 5110 H H6     . FDA D 3 .   ? 12.338  -24.724 13.48   1    17.974 ? 1403 FDA A H6     1 c 
HETATM 5111 H HM71   . FDA D 3 .   ? 11.557  -26.576 10.771  1    18.92  ? 1403 FDA A HM71   1 c 
HETATM 5112 H HM72   . FDA D 3 .   ? 11.743  -27.861 11.997  1    18.925 ? 1403 FDA A HM72   1 c 
HETATM 5113 H HM73   . FDA D 3 .   ? 12.824  -26.465 11.987  1    18.928 ? 1403 FDA A HM73   1 c 
HETATM 5114 H HM81   . FDA D 3 .   ? 8.995   -27.249 10.839  1    20.037 ? 1403 FDA A HM81   1 c 
HETATM 5115 H HM82   . FDA D 3 .   ? 7.937   -27.775 12.177  1    20.083 ? 1403 FDA A HM82   1 c 
HETATM 5116 H HM83   . FDA D 3 .   ? 9.562   -28.439 12.009  1    20.083 ? 1403 FDA A HM83   1 c 
HETATM 5117 H H9     . FDA D 3 .   ? 7.551   -25.973 13.518  1    17.67  ? 1403 FDA A H9     1 c 
HETATM 5118 H "H1'1" . FDA D 3 .   ? 6.323   -24.683 14.314  1    14.535 ? 1403 FDA A "H1'1" 1 c 
HETATM 5119 H "H1'2" . FDA D 3 .   ? 6.085   -23.239 15.186  1    14.397 ? 1403 FDA A "H1'2" 1 c 
HETATM 5120 H "H2'"  . FDA D 3 .   ? 7.067   -24.358 17.295  1    13.667 ? 1403 FDA A "H2'"  1 c 
HETATM 5121 H "HO2'" . FDA D 3 .   ? 8.044   -26.12  16.249  1    14.452 ? 1403 FDA A "HO2'" 1 ? 
HETATM 5122 H "H3'"  . FDA D 3 .   ? 5.002   -25.77  17.661  1    13.667 ? 1403 FDA A "H3'"  1 c 
HETATM 5123 H "HO3'" . FDA D 3 .   ? 3.707   -26.239 16.15   1    13.993 ? 1403 FDA A "HO3'" 1 ? 
HETATM 5124 H "H4'"  . FDA D 3 .   ? 4.391   -23.013 16.478  1    13.173 ? 1403 FDA A "H4'"  1 c 
HETATM 5125 H "HO4'" . FDA D 3 .   ? 5.035   -22.241 18.342  1    12.282 ? 1403 FDA A "HO4'" 1 ? 
HETATM 5126 H "H5'1" . FDA D 3 .   ? 2.329   -24.328 16.904  1    12.927 ? 1403 FDA A "H5'1" 1 c 
HETATM 5127 H "H5'2" . FDA D 3 .   ? 2.518   -23.094 18.159  1    12.931 ? 1403 FDA A "H5'2" 1 c 
HETATM 5128 O O      . HOH E 4 .   ? 16.316  -40.288 25.298  1    17.327 ? 1501 HOH A O      1 ? 
HETATM 5129 H H1     . HOH E 4 .   ? 17.029  -40.708 24.789  1    16.152 ? 1501 HOH A H1     1 ? 
HETATM 5130 O O      . HOH E 4 .   ? 10.84   -2.696  -2.873  1    24.273 ? 1502 HOH A O      1 ? 
HETATM 5131 H H1     . HOH E 4 .   ? 10.409  -3.2    -2.166  1    23.781 ? 1502 HOH A H1     1 ? 
HETATM 5132 H H2     . HOH E 4 .   ? 11.665  -2.335  -2.489  1    23.531 ? 1502 HOH A H2     1 ? 
HETATM 5133 O O      . HOH E 4 .   ? 28.687  -34.683 16.657  1    26.429 ? 1503 HOH A O      1 ? 
HETATM 5134 H H1     . HOH E 4 .   ? 28.469  -34.111 17.396  1    25.988 ? 1503 HOH A H1     1 ? 
HETATM 5135 H H2     . HOH E 4 .   ? 28.464  -35.587 16.939  1    26.39  ? 1503 HOH A H2     1 ? 
HETATM 5136 O O      . HOH E 4 .   ? 16.761  -11.233 -21.015 1    21.836 ? 1504 HOH A O      1 ? 
HETATM 5137 H H1     . HOH E 4 .   ? 16.093  -11.253 -21.721 1    21.854 ? 1504 HOH A H1     1 ? 
HETATM 5138 H H2     . HOH E 4 .   ? 16.97   -12.151 -20.783 1    21.431 ? 1504 HOH A H2     1 ? 
HETATM 5139 O O      . HOH E 4 .   ? 21.73   -23.517 35.249  1    42.903 ? 1505 HOH A O      1 ? 
HETATM 5140 H H1     . HOH E 4 .   ? 21.656  -22.768 35.871  1    43.049 ? 1505 HOH A H1     1 ? 
HETATM 5141 H H2     . HOH E 4 .   ? 20.964  -24.12  35.396  1    44.451 ? 1505 HOH A H2     1 ? 
HETATM 5142 O O      . HOH E 4 .   ? 27.936  -2.153  7.366   1    18.774 ? 1506 HOH A O      1 ? 
HETATM 5143 H H1     . HOH E 4 .   ? 27.874  -1.306  7.816   1    18.786 ? 1506 HOH A H1     1 ? 
HETATM 5144 H H2     . HOH E 4 .   ? 27.019  -2.464  7.273   1    18.463 ? 1506 HOH A H2     1 ? 
HETATM 5145 O O      . HOH E 4 .   ? 4.325   -14.785 -8.473  1    43.109 ? 1507 HOH A O      1 ? 
HETATM 5146 H H1     . HOH E 4 .   ? 4.238   -14.21  -9.253  1    39.638 ? 1507 HOH A H1     1 ? 
HETATM 5147 H H2     . HOH E 4 .   ? 3.98    -14.303 -7.69   1    40.842 ? 1507 HOH A H2     1 ? 
HETATM 5148 O O      . HOH E 4 .   ? 32.209  -29.572 16.069  1    34.952 ? 1508 HOH A O      1 ? 
HETATM 5149 H H1     . HOH E 4 .   ? 32.751  -28.908 15.548  1    31.862 ? 1508 HOH A H1     1 ? 
HETATM 5150 H H2     . HOH E 4 .   ? 31.904  -29.2   16.939  1    35.609 ? 1508 HOH A H2     1 ? 
HETATM 5151 O O      . HOH E 4 .   ? 16.543  -25.968 12.809  1    33.953 ? 1509 HOH A O      1 ? 
HETATM 5152 H H1     . HOH E 4 .   ? 17.431  -25.603 12.632  1    33.212 ? 1509 HOH A H1     1 ? 
HETATM 5153 H H2     . HOH E 4 .   ? 16.49   -26.828 12.335  1    32.771 ? 1509 HOH A H2     1 ? 
HETATM 5154 O O      . HOH E 4 .   ? 30.591  -24.822 1.96    1    47.743 ? 1510 HOH A O      1 ? 
HETATM 5155 H H1     . HOH E 4 .   ? 31.304  -25.461 2.099   1    45.705 ? 1510 HOH A H1     1 ? 
HETATM 5156 H H2     . HOH E 4 .   ? 30.208  -25.022 1.091   1    46.456 ? 1510 HOH A H2     1 ? 
HETATM 5157 O O      . HOH E 4 .   ? -1.726  -6.974  8.07    1    44.875 ? 1511 HOH A O      1 ? 
HETATM 5158 H H1     . HOH E 4 .   ? -0.957  -6.7    7.521   1    48.127 ? 1511 HOH A H1     1 ? 
HETATM 5159 H H2     . HOH E 4 .   ? -1.379  -7.428  8.857   1    46.989 ? 1511 HOH A H2     1 ? 
HETATM 5160 O O      . HOH E 4 .   ? 16.608  -30.344 34.945  1    40.016 ? 1512 HOH A O      1 ? 
HETATM 5161 H H1     . HOH E 4 .   ? 16.484  -31.323 34.981  1    34.291 ? 1512 HOH A H1     1 ? 
HETATM 5162 H H2     . HOH E 4 .   ? 17.401  -30.119 34.39   1    38.254 ? 1512 HOH A H2     1 ? 
HETATM 5163 O O      . HOH E 4 .   ? 17.811  -18.421 36.308  1    35.6   ? 1513 HOH A O      1 ? 
HETATM 5164 H H1     . HOH E 4 .   ? 17.904  -18.603 37.266  1    34.135 ? 1513 HOH A H1     1 ? 
HETATM 5165 H H2     . HOH E 4 .   ? 17.368  -17.552 36.195  1    34.891 ? 1513 HOH A H2     1 ? 
HETATM 5166 O O      . HOH E 4 .   ? 18.669  -23.166 14.906  1    14.963 ? 1514 HOH A O      1 ? 
HETATM 5167 H H1     . HOH E 4 .   ? 18.253  -23.079 14.037  1    17.056 ? 1514 HOH A H1     1 ? 
HETATM 5168 H H2     . HOH E 4 .   ? 18.567  -22.283 15.255  1    14.653 ? 1514 HOH A H2     1 ? 
HETATM 5169 O O      . HOH E 4 .   ? 7.598   -38.798 25.042  1    29.743 ? 1515 HOH A O      1 ? 
HETATM 5170 H H1     . HOH E 4 .   ? 8.074   -38.689 25.892  1    28.892 ? 1515 HOH A H1     1 ? 
HETATM 5171 H H2     . HOH E 4 .   ? 7.099   -37.984 24.872  1    29.188 ? 1515 HOH A H2     1 ? 
HETATM 5172 O O      . HOH E 4 .   ? 16.408  -39.278 29.069  1    25.685 ? 1516 HOH A O      1 ? 
HETATM 5173 H H1     . HOH E 4 .   ? 17.146  -39.903 29.156  1    25.367 ? 1516 HOH A H1     1 ? 
HETATM 5174 O O      . HOH E 4 .   ? 27.694  -0.708  9.581   1    19.87  ? 1517 HOH A O      1 ? 
HETATM 5175 H H1     . HOH E 4 .   ? 27.852  -0.251  10.417  1    21.435 ? 1517 HOH A H1     1 ? 
HETATM 5176 H H2     . HOH E 4 .   ? 27.625  -0.006  8.951   1    19.832 ? 1517 HOH A H2     1 ? 
HETATM 5177 O O      . HOH E 4 .   ? 37.211  -4.572  5.447   1    31.327 ? 1518 HOH A O      1 ? 
HETATM 5178 H H1     . HOH E 4 .   ? 37.542  -4.463  6.353   1    30.343 ? 1518 HOH A H1     1 ? 
HETATM 5179 H H2     . HOH E 4 .   ? 36.657  -3.79   5.282   1    31.555 ? 1518 HOH A H2     1 ? 
HETATM 5180 O O      . HOH E 4 .   ? 18.564  -27.551 -9.265  1    21.061 ? 1519 HOH A O      1 ? 
HETATM 5181 H H1     . HOH E 4 .   ? 17.686  -27.814 -9.588  1    20.084 ? 1519 HOH A H1     1 ? 
HETATM 5182 H H2     . HOH E 4 .   ? 18.898  -26.803 -9.809  1    21.855 ? 1519 HOH A H2     1 ? 
HETATM 5183 O O      . HOH E 4 .   ? 8.376   -30.591 28.919  1    17.442 ? 1520 HOH A O      1 ? 
HETATM 5184 H H1     . HOH E 4 .   ? 7.802   -30.157 28.284  1    18.345 ? 1520 HOH A H1     1 ? 
HETATM 5185 H H2     . HOH E 4 .   ? 8.031   -30.348 29.796  1    17.584 ? 1520 HOH A H2     1 ? 
HETATM 5186 O O      . HOH E 4 .   ? 17.951  -33.986 33.616  1    21.428 ? 1521 HOH A O      1 ? 
HETATM 5187 H H1     . HOH E 4 .   ? 18.9    -33.764 33.638  1    21.411 ? 1521 HOH A H1     1 ? 
HETATM 5188 H H2     . HOH E 4 .   ? 17.541  -33.608 34.42   1    21.929 ? 1521 HOH A H2     1 ? 
HETATM 5189 O O      . HOH E 4 .   ? 21.588  -20.392 25.807  1    12.828 ? 1522 HOH A O      1 ? 
HETATM 5190 H H1     . HOH E 4 .   ? 21.932  -20.062 26.64   1    13.499 ? 1522 HOH A H1     1 ? 
HETATM 5191 H H2     . HOH E 4 .   ? 20.929  -19.739 25.487  1    13.518 ? 1522 HOH A H2     1 ? 
HETATM 5192 O O      . HOH E 4 .   ? -3.338  -27.21  20.829  1    29.208 ? 1523 HOH A O      1 ? 
HETATM 5193 H H1     . HOH E 4 .   ? -3.485  -27.877 20.144  1    28.201 ? 1523 HOH A H1     1 ? 
HETATM 5194 H H2     . HOH E 4 .   ? -3.085  -26.385 20.377  1    27.95  ? 1523 HOH A H2     1 ? 
HETATM 5195 O O      . HOH E 4 .   ? 20.138  -26.072 3.344   1    18.935 ? 1524 HOH A O      1 ? 
HETATM 5196 H H1     . HOH E 4 .   ? 19.956  -26.209 4.309   1    19.789 ? 1524 HOH A H1     1 ? 
HETATM 5197 H H2     . HOH E 4 .   ? 20.053  -26.916 2.887   1    17.621 ? 1524 HOH A H2     1 ? 
HETATM 5198 O O      . HOH E 4 .   ? 18.647  -26.989 10.733  1    21.304 ? 1525 HOH A O      1 ? 
HETATM 5199 H H1     . HOH E 4 .   ? 17.925  -27.462 10.272  1    21.166 ? 1525 HOH A H1     1 ? 
HETATM 5200 H H2     . HOH E 4 .   ? 19.447  -27.527 10.581  1    22.321 ? 1525 HOH A H2     1 ? 
HETATM 5201 O O      . HOH E 4 .   ? -8.826  -15.928 14.979  1    44.404 ? 1526 HOH A O      1 ? 
HETATM 5202 H H1     . HOH E 4 .   ? -9.061  -16.642 14.353  1    45.231 ? 1526 HOH A H1     1 ? 
HETATM 5203 H H2     . HOH E 4 .   ? -9.535  -15.881 15.652  1    41.81  ? 1526 HOH A H2     1 ? 
HETATM 5204 O O      . HOH E 4 .   ? 17.628  -22.665 35.943  1    25.674 ? 1527 HOH A O      1 ? 
HETATM 5205 H H1     . HOH E 4 .   ? 17.684  -23.624 35.812  1    24.744 ? 1527 HOH A H1     1 ? 
HETATM 5206 H H2     . HOH E 4 .   ? 17.867  -22.482 36.872  1    23.88  ? 1527 HOH A H2     1 ? 
HETATM 5207 O O      . HOH E 4 .   ? 6.401   -14.405 29.207  1    32.557 ? 1528 HOH A O      1 ? 
HETATM 5208 H H1     . HOH E 4 .   ? 6.245   -15.361 29.104  1    29.292 ? 1528 HOH A H1     1 ? 
HETATM 5209 H H2     . HOH E 4 .   ? 6.325   -13.984 28.33   1    30.637 ? 1528 HOH A H2     1 ? 
HETATM 5210 O O      . HOH E 4 .   ? 25.063  -22.037 32.434  1    26.526 ? 1529 HOH A O      1 ? 
HETATM 5211 H H1     . HOH E 4 .   ? 25.942  -22.276 32.055  1    24.221 ? 1529 HOH A H1     1 ? 
HETATM 5212 H H2     . HOH E 4 .   ? 25.045  -22.403 33.333  1    23.379 ? 1529 HOH A H2     1 ? 
HETATM 5213 O O      . HOH E 4 .   ? 13.339  -8.34   25.904  1    29.331 ? 1530 HOH A O      1 ? 
HETATM 5214 H H1     . HOH E 4 .   ? 13.767  -7.685  26.487  1    29.269 ? 1530 HOH A H1     1 ? 
HETATM 5215 H H2     . HOH E 4 .   ? 13.344  -9.187  26.377  1    28.135 ? 1530 HOH A H2     1 ? 
HETATM 5216 O O      . HOH E 4 .   ? -3.94   -19.562 17.421  1    41.41  ? 1531 HOH A O      1 ? 
HETATM 5217 H H1     . HOH E 4 .   ? -3.775  -18.802 17.999  1    41.142 ? 1531 HOH A H1     1 ? 
HETATM 5218 H H2     . HOH E 4 .   ? -3.209  -20.192 17.57   1    41.95  ? 1531 HOH A H2     1 ? 
HETATM 5219 O O      . HOH E 4 .   ? 23.795  -37.541 19.439  1    37.72  ? 1532 HOH A O      1 ? 
HETATM 5220 H H1     . HOH E 4 .   ? 24.762  -37.562 19.341  1    33.468 ? 1532 HOH A H1     1 ? 
HETATM 5221 H H2     . HOH E 4 .   ? 23.535  -36.744 19.97   1    33.938 ? 1532 HOH A H2     1 ? 
HETATM 5222 O O      . HOH E 4 .   ? 16.15   -36.723 13.222  1    33.698 ? 1533 HOH A O      1 ? 
HETATM 5223 H H1     . HOH E 4 .   ? 16.417  -36.922 12.313  1    32.569 ? 1533 HOH A H1     1 ? 
HETATM 5224 H H2     . HOH E 4 .   ? 15.559  -35.95  13.178  1    35.251 ? 1533 HOH A H2     1 ? 
HETATM 5225 O O      . HOH E 4 .   ? -3.484  -32.748 27.023  1    25.061 ? 1534 HOH A O      1 ? 
HETATM 5226 H H1     . HOH E 4 .   ? -3.02   -33.587 26.896  1    23.318 ? 1534 HOH A H1     1 ? 
HETATM 5227 H H2     . HOH E 4 .   ? -3.34   -32.23  26.207  1    24.729 ? 1534 HOH A H2     1 ? 
HETATM 5228 O O      . HOH E 4 .   ? 16.411  0.141   15.47   1    37.2   ? 1535 HOH A O      1 ? 
HETATM 5229 H H1     . HOH E 4 .   ? 17.281  -0.276  15.652  1    34.122 ? 1535 HOH A H1     1 ? 
HETATM 5230 H H2     . HOH E 4 .   ? 16.553  1.106   15.439  1    36.952 ? 1535 HOH A H2     1 ? 
HETATM 5231 O O      . HOH E 4 .   ? -13.568 -16.717 26.153  1    38.517 ? 1536 HOH A O      1 ? 
HETATM 5232 H H1     . HOH E 4 .   ? -12.647 -16.862 26.44   1    34.742 ? 1536 HOH A H1     1 ? 
HETATM 5233 H H2     . HOH E 4 .   ? -13.947 -16.014 26.713  1    37.167 ? 1536 HOH A H2     1 ? 
HETATM 5234 O O      . HOH E 4 .   ? 0.383   -33.729 21.578  1    23.181 ? 1537 HOH A O      1 ? 
HETATM 5235 H H1     . HOH E 4 .   ? -0.231  -33.92  20.85   1    21.722 ? 1537 HOH A H1     1 ? 
HETATM 5236 H H2     . HOH E 4 .   ? -0.109  -33.308 22.333  1    23.969 ? 1537 HOH A H2     1 ? 
HETATM 5237 O O      . HOH E 4 .   ? 39.585  -23.087 10.672  1    47.871 ? 1538 HOH A O      1 ? 
HETATM 5238 H H1     . HOH E 4 .   ? 39.415  -24.048 10.772  1    43.553 ? 1538 HOH A H1     1 ? 
HETATM 5239 H H2     . HOH E 4 .   ? 40.394  -22.836 11.176  1    44.772 ? 1538 HOH A H2     1 ? 
HETATM 5240 O O      . HOH E 4 .   ? 6.126   -37.508 22.902  1    34.817 ? 1539 HOH A O      1 ? 
HETATM 5241 H H1     . HOH E 4 .   ? 6.502   -38.38  23.148  1    31.256 ? 1539 HOH A H1     1 ? 
HETATM 5242 H H2     . HOH E 4 .   ? 6.031   -37.461 21.926  1    32.855 ? 1539 HOH A H2     1 ? 
HETATM 5243 O O      . HOH E 4 .   ? 37.865  -23.912 5.532   1    44.184 ? 1540 HOH A O      1 ? 
HETATM 5244 H H1     . HOH E 4 .   ? 37.685  -24.322 4.656   1    39.66  ? 1540 HOH A H1     1 ? 
HETATM 5245 H H2     . HOH E 4 .   ? 38.245  -24.594 6.118   1    41.711 ? 1540 HOH A H2     1 ? 
HETATM 5246 O O      . HOH E 4 .   ? 8.311   -4.724  -13.037 1    41.969 ? 1541 HOH A O      1 ? 
HETATM 5247 H H1     . HOH E 4 .   ? 7.911   -4.276  -13.807 1    38.417 ? 1541 HOH A H1     1 ? 
HETATM 5248 H H2     . HOH E 4 .   ? 8.303   -5.688  -13.201 1    40.571 ? 1541 HOH A H2     1 ? 
HETATM 5249 O O      . HOH E 4 .   ? 25.418  -20.836 27.913  1    16.733 ? 1542 HOH A O      1 ? 
HETATM 5250 H H1     . HOH E 4 .   ? 25.755  -20.968 27.008  1    17.481 ? 1542 HOH A H1     1 ? 
HETATM 5251 H H2     . HOH E 4 .   ? 26.081  -21.218 28.496  1    16.893 ? 1542 HOH A H2     1 ? 
HETATM 5252 O O      . HOH E 4 .   ? 37.831  -20.971 25.778  1    18.419 ? 1543 HOH A O      1 ? 
HETATM 5253 H H1     . HOH E 4 .   ? 37.748  -20.717 26.694  1    16.793 ? 1543 HOH A H1     1 ? 
HETATM 5254 H H2     . HOH E 4 .   ? 36.934  -21.211 25.5    1    17.887 ? 1543 HOH A H2     1 ? 
HETATM 5255 O O      . HOH E 4 .   ? 27.963  -22.917 12.731  1    28.054 ? 1544 HOH A O      1 ? 
HETATM 5256 H H1     . HOH E 4 .   ? 28.832  -23.276 12.494  1    28.523 ? 1544 HOH A H1     1 ? 
HETATM 5257 H H2     . HOH E 4 .   ? 27.878  -23.006 13.702  1    25.86  ? 1544 HOH A H2     1 ? 
HETATM 5258 O O      . HOH E 4 .   ? 5.263   1.203   21.929  1    36.865 ? 1545 HOH A O      1 ? 
HETATM 5259 H H1     . HOH E 4 .   ? 5.157   0.327   22.354  1    37.018 ? 1545 HOH A H1     1 ? 
HETATM 5260 H H2     . HOH E 4 .   ? 5.853   1.76    22.478  1    34.715 ? 1545 HOH A H2     1 ? 
HETATM 5261 O O      . HOH E 4 .   ? -1.492  -31.415 22.097  1    25.414 ? 1546 HOH A O      1 ? 
HETATM 5262 H H1     . HOH E 4 .   ? -1.338  -31.748 23.015  1    24.262 ? 1546 HOH A H1     1 ? 
HETATM 5263 H H2     . HOH E 4 .   ? -2.045  -30.614 22.158  1    24.152 ? 1546 HOH A H2     1 ? 
HETATM 5264 O O      . HOH E 4 .   ? 15.538  -6.742  15.208  1    30.522 ? 1547 HOH A O      1 ? 
HETATM 5265 H H1     . HOH E 4 .   ? 15.406  -7.344  15.967  1    29.137 ? 1547 HOH A H1     1 ? 
HETATM 5266 H H2     . HOH E 4 .   ? 16.229  -7.134  14.641  1    29.323 ? 1547 HOH A H2     1 ? 
HETATM 5267 O O      . HOH E 4 .   ? 38.15   -14.439 7.553   1    29.558 ? 1548 HOH A O      1 ? 
HETATM 5268 H H1     . HOH E 4 .   ? 38.136  -15.196 8.172   1    29.532 ? 1548 HOH A H1     1 ? 
HETATM 5269 H H2     . HOH E 4 .   ? 38.098  -14.782 6.631   1    26.188 ? 1548 HOH A H2     1 ? 
HETATM 5270 O O      . HOH E 4 .   ? 24.8    -13.589 26.173  1    17.443 ? 1549 HOH A O      1 ? 
HETATM 5271 H H1     . HOH E 4 .   ? 24.452  -14.165 26.839  1    18.12  ? 1549 HOH A H1     1 ? 
HETATM 5272 H H2     . HOH E 4 .   ? 24.141  -12.879 26.154  1    19.298 ? 1549 HOH A H2     1 ? 
HETATM 5273 O O      . HOH E 4 .   ? 4.535   -20.296 18.018  1    19.775 ? 1550 HOH A O      1 ? 
HETATM 5274 H H1     . HOH E 4 .   ? 5.436   -20.634 17.882  1    20.544 ? 1550 HOH A H1     1 ? 
HETATM 5275 H H2     . HOH E 4 .   ? 4.508   -19.979 18.941  1    19.915 ? 1550 HOH A H2     1 ? 
HETATM 5276 O O      . HOH E 4 .   ? 11.564  -0.378  5.766   1    51.716 ? 1551 HOH A O      1 ? 
HETATM 5277 H H1     . HOH E 4 .   ? 12.331  0.031   5.329   1    52.824 ? 1551 HOH A H1     1 ? 
HETATM 5278 H H2     . HOH E 4 .   ? 10.782  -0.124  5.25    1    50.595 ? 1551 HOH A H2     1 ? 
HETATM 5279 O O      . HOH E 4 .   ? 33.397  -14.366 16.109  1    15.222 ? 1552 HOH A O      1 ? 
HETATM 5280 H H1     . HOH E 4 .   ? 33.291  -14.438 17.086  1    15.294 ? 1552 HOH A H1     1 ? 
HETATM 5281 H H2     . HOH E 4 .   ? 32.645  -14.821 15.693  1    15.062 ? 1552 HOH A H2     1 ? 
HETATM 5282 O O      . HOH E 4 .   ? 22.643  -25.175 5.501   1    23.678 ? 1553 HOH A O      1 ? 
HETATM 5283 H H1     . HOH E 4 .   ? 23.35   -24.588 5.864   1    22.548 ? 1553 HOH A H1     1 ? 
HETATM 5284 H H2     . HOH E 4 .   ? 21.89   -24.634 5.175   1    22.995 ? 1553 HOH A H2     1 ? 
HETATM 5285 O O      . HOH E 4 .   ? 7.871   -12.783 16.697  1    22.247 ? 1554 HOH A O      1 ? 
HETATM 5286 H H1     . HOH E 4 .   ? 7.584   -13.086 15.831  1    25.306 ? 1554 HOH A H1     1 ? 
HETATM 5287 H H2     . HOH E 4 .   ? 7.563   -13.464 17.307  1    26.049 ? 1554 HOH A H2     1 ? 
HETATM 5288 O O      . HOH E 4 .   ? 14.883  -31.782 17.592  1    20.143 ? 1555 HOH A O      1 ? 
HETATM 5289 H H1     . HOH E 4 .   ? 14.498  -32.584 17.985  1    19.264 ? 1555 HOH A H1     1 ? 
HETATM 5290 H H2     . HOH E 4 .   ? 14.939  -31.128 18.32   1    20.251 ? 1555 HOH A H2     1 ? 
HETATM 5291 O O      . HOH E 4 .   ? 21.97   -11.707 -12.351 1    27.45  ? 1556 HOH A O      1 ? 
HETATM 5292 H H1     . HOH E 4 .   ? 21.899  -12.067 -13.258 1    29.346 ? 1556 HOH A H1     1 ? 
HETATM 5293 H H2     . HOH E 4 .   ? 22.65   -12.225 -11.893 1    25.626 ? 1556 HOH A H2     1 ? 
HETATM 5294 O O      . HOH E 4 .   ? 2.187   -27.412 16.636  1    21.754 ? 1557 HOH A O      1 ? 
HETATM 5295 H H1     . HOH E 4 .   ? 1.821   -27.136 15.784  1    21.2   ? 1557 HOH A H1     1 ? 
HETATM 5296 H H2     . HOH E 4 .   ? 1.541   -27.099 17.319  1    22.187 ? 1557 HOH A H2     1 ? 
HETATM 5297 O O      . HOH E 4 .   ? 23.661  -30.38  -6.657  1    42.792 ? 1558 HOH A O      1 ? 
HETATM 5298 H H1     . HOH E 4 .   ? 22.89   -30.911 -6.397  1    42.187 ? 1558 HOH A H1     1 ? 
HETATM 5299 H H2     . HOH E 4 .   ? 23.765  -29.672 -5.993  1    41.426 ? 1558 HOH A H2     1 ? 
HETATM 5300 O O      . HOH E 4 .   ? 33.266  -1.226  1.844   1    33.764 ? 1559 HOH A O      1 ? 
HETATM 5301 H H1     . HOH E 4 .   ? 34.224  -1.062  2.009   1    27.134 ? 1559 HOH A H1     1 ? 
HETATM 5302 H H2     . HOH E 4 .   ? 33.056  -1.204  0.877   1    28.606 ? 1559 HOH A H2     1 ? 
HETATM 5303 O O      . HOH E 4 .   ? -5.239  -25.988 22.244  1    47.123 ? 1560 HOH A O      1 ? 
HETATM 5304 H H1     . HOH E 4 .   ? -4.53   -26.514 21.84   1    48.884 ? 1560 HOH A H1     1 ? 
HETATM 5305 H H2     . HOH E 4 .   ? -6.076  -26.315 21.87   1    47.686 ? 1560 HOH A H2     1 ? 
HETATM 5306 O O      . HOH E 4 .   ? -13.939 -19.187 25.300  1    43.912 ? 1561 HOH A O      1 ? 
HETATM 5307 H H1     . HOH E 4 .   ? -13.651 -19.719 26.073  1    38.674 ? 1561 HOH A H1     1 ? 
HETATM 5308 H H2     . HOH E 4 .   ? -14.728 -19.623 24.892  1    45.857 ? 1561 HOH A H2     1 ? 
HETATM 5309 O O      . HOH E 4 .   ? 16.572  -1.211  19.216  1    40.942 ? 1562 HOH A O      1 ? 
HETATM 5310 H H1     . HOH E 4 .   ? 15.631  -1.358  18.987  1    41.114 ? 1562 HOH A H1     1 ? 
HETATM 5311 H H2     . HOH E 4 .   ? 17.089  -1.332  18.39   1    40.04  ? 1562 HOH A H2     1 ? 
HETATM 5312 O O      . HOH E 4 .   ? 10.648  -29.610 0.119   1    59.849 ? 1563 HOH A O      1 ? 
HETATM 5313 H H1     . HOH E 4 .   ? 9.837   -29.102 0.324   1    56.768 ? 1563 HOH A H1     1 ? 
HETATM 5314 H H2     . HOH E 4 .   ? 11.174  -29.108 -0.541  1    52.586 ? 1563 HOH A H2     1 ? 
HETATM 5315 O O      . HOH E 4 .   ? -1.928  -11.417 20.705  1    36.957 ? 1564 HOH A O      1 ? 
HETATM 5316 H H1     . HOH E 4 .   ? -1.741  -11.542 19.749  1    39.203 ? 1564 HOH A H1     1 ? 
HETATM 5317 H H2     . HOH E 4 .   ? -1.737  -12.258 21.174  1    37.136 ? 1564 HOH A H2     1 ? 
HETATM 5318 O O      . HOH E 4 .   ? 23.289  -33.552 21.386  1    19.415 ? 1565 HOH A O      1 ? 
HETATM 5319 H H1     . HOH E 4 .   ? 24.155  -33.967 21.458  1    19.305 ? 1565 HOH A H1     1 ? 
HETATM 5320 H H2     . HOH E 4 .   ? 23.426  -32.58  21.344  1    21.025 ? 1565 HOH A H2     1 ? 
HETATM 5321 O O      . HOH E 4 .   ? 12.741  -19.812 13.776  1    16.619 ? 1566 HOH A O      1 ? 
HETATM 5322 H H1     . HOH E 4 .   ? 13.125  -20.724 13.723  1    16.546 ? 1566 HOH A H1     1 ? 
HETATM 5323 H H2     . HOH E 4 .   ? 12.713  -19.552 14.698  1    17.597 ? 1566 HOH A H2     1 ? 
HETATM 5324 O O      . HOH E 4 .   ? 13.727  -26.919 3.1     1    47.636 ? 1567 HOH A O      1 ? 
HETATM 5325 H H1     . HOH E 4 .   ? 14.072  -26.115 3.548   1    40.236 ? 1567 HOH A H1     1 ? 
HETATM 5326 H H2     . HOH E 4 .   ? 13.209  -27.456 3.744   1    44.521 ? 1567 HOH A H2     1 ? 
HETATM 5327 O O      . HOH E 4 .   ? 12.387  -28.659 8.91    1    26.619 ? 1568 HOH A O      1 ? 
HETATM 5328 H H1     . HOH E 4 .   ? 13.259  -28.512 8.491   1    25.885 ? 1568 HOH A H1     1 ? 
HETATM 5329 H H2     . HOH E 4 .   ? 11.706  -28.596 8.21    1    26.348 ? 1568 HOH A H2     1 ? 
HETATM 5330 O O      . HOH E 4 .   ? 34.143  -12.256 1.092   1    26.17  ? 1569 HOH A O      1 ? 
HETATM 5331 H H1     . HOH E 4 .   ? 35.083  -12.031 0.979   1    25.46  ? 1569 HOH A H1     1 ? 
HETATM 5332 H H2     . HOH E 4 .   ? 33.614  -11.487 0.778   1    24.139 ? 1569 HOH A H2     1 ? 
HETATM 5333 O O      . HOH E 4 .   ? 13.792  -37.232 31.265  1    34.216 ? 1570 HOH A O      1 ? 
HETATM 5334 H H1     . HOH E 4 .   ? 13.809  -37.414 30.302  1    31.765 ? 1570 HOH A H1     1 ? 
HETATM 5335 H H2     . HOH E 4 .   ? 12.85   -37.157 31.514  1    30.376 ? 1570 HOH A H2     1 ? 
HETATM 5336 O O      . HOH E 4 .   ? -20.471 -12.137 22.581  1    36.492 ? 1571 HOH A O      1 ? 
HETATM 5337 H H1     . HOH E 4 .   ? -20.017 -12.896 22.162  1    36.101 ? 1571 HOH A H1     1 ? 
HETATM 5338 H H2     . HOH E 4 .   ? -20.482 -11.383 21.954  1    35.741 ? 1571 HOH A H2     1 ? 
HETATM 5339 O O      . HOH E 4 .   ? 37.242  -22.545 1.612   1    37.538 ? 1572 HOH A O      1 ? 
HETATM 5340 H H1     . HOH E 4 .   ? 37.406  -22.466 0.648   1    36.244 ? 1572 HOH A H1     1 ? 
HETATM 5341 H H2     . HOH E 4 .   ? 38.076  -22.336 2.062   1    35.448 ? 1572 HOH A H2     1 ? 
HETATM 5342 O O      . HOH E 4 .   ? 34.284  -10.118 10.367  1    27.963 ? 1573 HOH A O      1 ? 
HETATM 5343 H H1     . HOH E 4 .   ? 34.855  -10.818 9.986   1    27.017 ? 1573 HOH A H1     1 ? 
HETATM 5344 H H2     . HOH E 4 .   ? 34.861  -9.372  10.601  1    27.378 ? 1573 HOH A H2     1 ? 
HETATM 5345 O O      . HOH E 4 .   ? 37.331  -12.668 25.069  1    24.485 ? 1574 HOH A O      1 ? 
HETATM 5346 H H1     . HOH E 4 .   ? 37.117  -12.712 24.116  1    22.86  ? 1574 HOH A H1     1 ? 
HETATM 5347 H H2     . HOH E 4 .   ? 37.976  -11.948 25.202  1    22.965 ? 1574 HOH A H2     1 ? 
HETATM 5348 O O      . HOH E 4 .   ? 5.527   -10.784 18.97   1    22.034 ? 1575 HOH A O      1 ? 
HETATM 5349 H H1     . HOH E 4 .   ? 4.66    -10.947 19.394  1    21.784 ? 1575 HOH A H1     1 ? 
HETATM 5350 H H2     . HOH E 4 .   ? 5.365   -10.686 18.029  1    21.524 ? 1575 HOH A H2     1 ? 
HETATM 5351 O O      . HOH E 4 .   ? 26.255  -11.33  -12.079 1    32.383 ? 1576 HOH A O      1 ? 
HETATM 5352 H H1     . HOH E 4 .   ? 25.806  -11.414 -11.221 1    31.191 ? 1576 HOH A H1     1 ? 
HETATM 5353 H H2     . HOH E 4 .   ? 27.07   -10.81  -11.916 1    32.509 ? 1576 HOH A H2     1 ? 
HETATM 5354 O O      . HOH E 4 .   ? 34.521  -24.518 10.569  1    39.085 ? 1577 HOH A O      1 ? 
HETATM 5355 H H1     . HOH E 4 .   ? 34.858  -23.626 10.806  1    36.098 ? 1577 HOH A H1     1 ? 
HETATM 5356 H H2     . HOH E 4 .   ? 33.722  -24.691 11.102  1    37.346 ? 1577 HOH A H2     1 ? 
HETATM 5357 O O      . HOH E 4 .   ? 22.954  -16.632 -8.924  1    15.037 ? 1578 HOH A O      1 ? 
HETATM 5358 H H1     . HOH E 4 .   ? 23.549  -16.04  -9.384  1    15.057 ? 1578 HOH A H1     1 ? 
HETATM 5359 H H2     . HOH E 4 .   ? 22.45   -17.084 -9.624  1    15.436 ? 1578 HOH A H2     1 ? 
HETATM 5360 O O      . HOH E 4 .   ? 14.245  -36.622 14.841  1    38.435 ? 1579 HOH A O      1 ? 
HETATM 5361 H H1     . HOH E 4 .   ? 15.155  -36.514 15.242  1    41.316 ? 1579 HOH A H1     1 ? 
HETATM 5362 H H2     . HOH E 4 .   ? 14.099  -35.906 14.191  1    35.198 ? 1579 HOH A H2     1 ? 
HETATM 5363 O O      . HOH E 4 .   ? 8.421   -6.703  -3.804  1    21.842 ? 1580 HOH A O      1 ? 
HETATM 5364 H H1     . HOH E 4 .   ? 9.129   -6.057  -3.928  1    22.907 ? 1580 HOH A H1     1 ? 
HETATM 5365 H H2     . HOH E 4 .   ? 8.237   -6.683  -2.85   1    23.186 ? 1580 HOH A H2     1 ? 
HETATM 5366 O O      . HOH E 4 .   ? 25.242  -36.599 28.622  1    45.778 ? 1581 HOH A O      1 ? 
HETATM 5367 H H1     . HOH E 4 .   ? 25.293  -35.714 29.027  1    45.427 ? 1581 HOH A H1     1 ? 
HETATM 5368 H H2     . HOH E 4 .   ? 24.394  -36.654 28.137  1    43.839 ? 1581 HOH A H2     1 ? 
HETATM 5369 O O      . HOH E 4 .   ? -14.787 -19.259 18.62   1    31.618 ? 1582 HOH A O      1 ? 
HETATM 5370 H H1     . HOH E 4 .   ? -15.091 -18.467 18.125  1    30.314 ? 1582 HOH A H1     1 ? 
HETATM 5371 H H2     . HOH E 4 .   ? -15.222 -20.033 18.196  1    30.121 ? 1582 HOH A H2     1 ? 
HETATM 5372 O O      . HOH E 4 .   ? 9.405   -6.246  26.486  1    38.982 ? 1583 HOH A O      1 ? 
HETATM 5373 H H1     . HOH E 4 .   ? 8.863   -6.235  27.307  1    35.564 ? 1583 HOH A H1     1 ? 
HETATM 5374 H H2     . HOH E 4 .   ? 8.818   -6.431  25.722  1    36.39  ? 1583 HOH A H2     1 ? 
HETATM 5375 O O      . HOH E 4 .   ? 26.523  -16.834 22.713  1    15.348 ? 1584 HOH A O      1 ? 
HETATM 5376 H H1     . HOH E 4 .   ? 27.383  -16.753 22.273  1    14.968 ? 1584 HOH A H1     1 ? 
HETATM 5377 H H2     . HOH E 4 .   ? 26.664  -17.063 23.649  1    16.019 ? 1584 HOH A H2     1 ? 
HETATM 5378 O O      . HOH E 4 .   ? 21.976  -2.624  3.583   1    23.417 ? 1585 HOH A O      1 ? 
HETATM 5379 H H1     . HOH E 4 .   ? 21.134  -2.959  3.952   1    24.146 ? 1585 HOH A H1     1 ? 
HETATM 5380 H H2     . HOH E 4 .   ? 22.355  -2.097  4.286   1    24.062 ? 1585 HOH A H2     1 ? 
HETATM 5381 O O      . HOH E 4 .   ? 2.705   -21.568 9.323   1    32.242 ? 1586 HOH A O      1 ? 
HETATM 5382 H H1     . HOH E 4 .   ? 3.564   -21.786 8.915   1    33.35  ? 1586 HOH A H1     1 ? 
HETATM 5383 H H2     . HOH E 4 .   ? 2.87    -20.883 10.007  1    32.32  ? 1586 HOH A H2     1 ? 
HETATM 5384 O O      . HOH E 4 .   ? 12.783  -20.806 18.762  1    19.014 ? 1587 HOH A O      1 ? 
HETATM 5385 H H1     . HOH E 4 .   ? 13.651  -21.234 18.583  1    18.166 ? 1587 HOH A H1     1 ? 
HETATM 5386 H H2     . HOH E 4 .   ? 12.33   -20.727 17.903  1    18.922 ? 1587 HOH A H2     1 ? 
HETATM 5387 O O      . HOH E 4 .   ? 13.188  -0.238  7.864   1    36.72  ? 1588 HOH A O      1 ? 
HETATM 5388 H H1     . HOH E 4 .   ? 14.159  -0.259  7.931   1    35.184 ? 1588 HOH A H1     1 ? 
HETATM 5389 H H2     . HOH E 4 .   ? 12.862  -1.162  7.891   1    32.881 ? 1588 HOH A H2     1 ? 
HETATM 5390 O O      . HOH E 4 .   ? 6.675   -33.839 28.437  1    34.151 ? 1589 HOH A O      1 ? 
HETATM 5391 H H1     . HOH E 4 .   ? 6.701   -32.951 28.819  1    35.898 ? 1589 HOH A H1     1 ? 
HETATM 5392 H H2     . HOH E 4 .   ? 6.666   -34.468 29.167  1    35.526 ? 1589 HOH A H2     1 ? 
HETATM 5393 O O      . HOH E 4 .   ? 10.089  -20.021 -7.685  1    31.931 ? 1590 HOH A O      1 ? 
HETATM 5394 H H1     . HOH E 4 .   ? 9.671   -20.602 -8.354  1    31.954 ? 1590 HOH A H1     1 ? 
HETATM 5395 H H2     . HOH E 4 .   ? 9.377   -19.599 -7.176  1    30.914 ? 1590 HOH A H2     1 ? 
HETATM 5396 O O      . HOH E 4 .   ? 32.204  -14.337 -0.405  1    29.935 ? 1591 HOH A O      1 ? 
HETATM 5397 H H1     . HOH E 4 .   ? 33.012  -14.453 0.132   1    29.795 ? 1591 HOH A H1     1 ? 
HETATM 5398 H H2     . HOH E 4 .   ? 31.759  -13.55  -0.077  1    26.03  ? 1591 HOH A H2     1 ? 
HETATM 5399 O O      . HOH E 4 .   ? 7.437   -15.68  10.682  1    27.057 ? 1592 HOH A O      1 ? 
HETATM 5400 H H1     . HOH E 4 .   ? 7.595   -15.787 11.632  1    25.779 ? 1592 HOH A H1     1 ? 
HETATM 5401 H H2     . HOH E 4 .   ? 8.308   -15.628 10.254  1    28.735 ? 1592 HOH A H2     1 ? 
HETATM 5402 O O      . HOH E 4 .   ? 25.988  -25.17  11.873  1    17.716 ? 1593 HOH A O      1 ? 
HETATM 5403 H H1     . HOH E 4 .   ? 26.44   -24.335 12.058  1    16.287 ? 1593 HOH A H1     1 ? 
HETATM 5404 H H2     . HOH E 4 .   ? 25.103  -25.11  12.262  1    17.118 ? 1593 HOH A H2     1 ? 
HETATM 5405 O O      . HOH E 4 .   ? 29.542  -17.406 -0.842  1    17.025 ? 1594 HOH A O      1 ? 
HETATM 5406 H H1     . HOH E 4 .   ? 28.931  -18.179 -0.81   1    16.818 ? 1594 HOH A H1     1 ? 
HETATM 5407 H H2     . HOH E 4 .   ? 30.447  -17.743 -0.739  1    17.476 ? 1594 HOH A H2     1 ? 
HETATM 5408 O O      . HOH E 4 .   ? 23.278  -28.817 5.546   1    22.935 ? 1595 HOH A O      1 ? 
HETATM 5409 H H1     . HOH E 4 .   ? 22.792  -29.21  6.302   1    23.834 ? 1595 HOH A H1     1 ? 
HETATM 5410 H H2     . HOH E 4 .   ? 23.706  -29.539 5.048   1    24.544 ? 1595 HOH A H2     1 ? 
HETATM 5411 O O      . HOH E 4 .   ? 27.752  -11.101 -9.709  1    30.15  ? 1596 HOH A O      1 ? 
HETATM 5412 H H1     . HOH E 4 .   ? 27.522  -11.359 -8.799  1    28.155 ? 1596 HOH A H1     1 ? 
HETATM 5413 H H2     . HOH E 4 .   ? 28.728  -11.14  -9.761  1    29.968 ? 1596 HOH A H2     1 ? 
HETATM 5414 O O      . HOH E 4 .   ? -7.288  -18.215 23.518  1    27.935 ? 1597 HOH A O      1 ? 
HETATM 5415 H H1     . HOH E 4 .   ? -7.334  -17.402 22.974  1    26.911 ? 1597 HOH A H1     1 ? 
HETATM 5416 H H2     . HOH E 4 .   ? -6.344  -18.364 23.689  1    28.104 ? 1597 HOH A H2     1 ? 
HETATM 5417 O O      . HOH E 4 .   ? 33.638  -14.597 28.407  1    30.054 ? 1598 HOH A O      1 ? 
HETATM 5418 H H1     . HOH E 4 .   ? 32.752  -14.223 28.625  1    27.724 ? 1598 HOH A H1     1 ? 
HETATM 5419 H H2     . HOH E 4 .   ? 33.561  -15.185 27.616  1    27.224 ? 1598 HOH A H2     1 ? 
HETATM 5420 O O      . HOH E 4 .   ? 10.636  -5.209  20.168  1    29.91  ? 1599 HOH A O      1 ? 
HETATM 5421 H H1     . HOH E 4 .   ? 11.333  -5.757  19.769  1    29.97  ? 1599 HOH A H1     1 ? 
HETATM 5422 H H2     . HOH E 4 .   ? 10.954  -4.293  20.126  1    30.332 ? 1599 HOH A H2     1 ? 
HETATM 5423 O O      . HOH E 4 .   ? 20.165  -28.027 -2.89   1    35.763 ? 1600 HOH A O      1 ? 
HETATM 5424 H H1     . HOH E 4 .   ? 19.317  -27.543 -2.959  1    31.941 ? 1600 HOH A H1     1 ? 
HETATM 5425 H H2     . HOH E 4 .   ? 20.719  -27.862 -3.692  1    32.144 ? 1600 HOH A H2     1 ? 
HETATM 5426 O O      . HOH E 4 .   ? 8.331   -22.389 -12.441 1    40.589 ? 1601 HOH A O      1 ? 
HETATM 5427 H H1     . HOH E 4 .   ? 8.688   -23.290 -12.504 1    40.498 ? 1601 HOH A H1     1 ? 
HETATM 5428 H H2     . HOH E 4 .   ? 7.736   -22.369 -11.674 1    39.007 ? 1601 HOH A H2     1 ? 
HETATM 5429 O O      . HOH E 4 .   ? -1.393  -19.186 28.124  1    31.121 ? 1602 HOH A O      1 ? 
HETATM 5430 H H1     . HOH E 4 .   ? -0.466  -19.31  27.827  1    30.91  ? 1602 HOH A H1     1 ? 
HETATM 5431 H H2     . HOH E 4 .   ? -1.395  -18.762 29.007  1    29.031 ? 1602 HOH A H2     1 ? 
HETATM 5432 O O      . HOH E 4 .   ? 2.789   -34.591 31.418  1    29.273 ? 1603 HOH A O      1 ? 
HETATM 5433 H H1     . HOH E 4 .   ? 2.781   -35.539 31.7    1    27.494 ? 1603 HOH A H1     1 ? 
HETATM 5434 H H2     . HOH E 4 .   ? 2.668   -34.012 32.204  1    28.263 ? 1603 HOH A H2     1 ? 
HETATM 5435 O O      . HOH E 4 .   ? 31.685  -19.003 -0.731  1    24.277 ? 1604 HOH A O      1 ? 
HETATM 5436 H H1     . HOH E 4 .   ? 31.601  -19.96  -0.835  1    24.936 ? 1604 HOH A H1     1 ? 
HETATM 5437 H H2     . HOH E 4 .   ? 32.448  -18.861 -0.153  1    24.932 ? 1604 HOH A H2     1 ? 
HETATM 5438 O O      . HOH E 4 .   ? 19.11   -1.305  9.699   1    42.628 ? 1605 HOH A O      1 ? 
HETATM 5439 H H1     . HOH E 4 .   ? 20.007  -1.589  9.441   1    43.083 ? 1605 HOH A H1     1 ? 
HETATM 5440 H H2     . HOH E 4 .   ? 19.176  -0.858  10.564  1    40.73  ? 1605 HOH A H2     1 ? 
HETATM 5441 O O      . HOH E 4 .   ? 28.515  -20.936 -3.177  1    18.013 ? 1606 HOH A O      1 ? 
HETATM 5442 H H1     . HOH E 4 .   ? 28.616  -21.065 -4.137  1    18.189 ? 1606 HOH A H1     1 ? 
HETATM 5443 H H2     . HOH E 4 .   ? 28.712  -20.006 -2.995  1    18.581 ? 1606 HOH A H2     1 ? 
HETATM 5444 O O      . HOH E 4 .   ? 25.101  -35.941 12.147  1    43.326 ? 1607 HOH A O      1 ? 
HETATM 5445 H H1     . HOH E 4 .   ? 25.256  -36.902 12.125  1    42.106 ? 1607 HOH A H1     1 ? 
HETATM 5446 H H2     . HOH E 4 .   ? 25.449  -35.587 12.988  1    40.474 ? 1607 HOH A H2     1 ? 
HETATM 5447 O O      . HOH E 4 .   ? 9.216   0.724   19.231  1    49.563 ? 1608 HOH A O      1 ? 
HETATM 5448 H H1     . HOH E 4 .   ? 8.266   0.543   19.388  1    50.871 ? 1608 HOH A H1     1 ? 
HETATM 5449 H H2     . HOH E 4 .   ? 9.717   -0.067  19.501  1    48.088 ? 1608 HOH A H2     1 ? 
HETATM 5450 O O      . HOH E 4 .   ? 28.611  -13.675 -3.136  1    27.652 ? 1609 HOH A O      1 ? 
HETATM 5451 H H1     . HOH E 4 .   ? 29.229  -14.402 -3.336  1    27.346 ? 1609 HOH A H1     1 ? 
HETATM 5452 H H2     . HOH E 4 .   ? 28.827  -12.946 -3.728  1    25.868 ? 1609 HOH A H2     1 ? 
HETATM 5453 O O      . HOH E 4 .   ? 33.068  -31.744 19.89   1    25.659 ? 1610 HOH A O      1 ? 
HETATM 5454 H H1     . HOH E 4 .   ? 33.612  -31.215 20.483  1    27.247 ? 1610 HOH A H1     1 ? 
HETATM 5455 H H2     . HOH E 4 .   ? 32.316  -32.038 20.427  1    25.874 ? 1610 HOH A H2     1 ? 
HETATM 5456 O O      . HOH E 4 .   ? 34.486  -16.13  -0.937  1    36.128 ? 1611 HOH A O      1 ? 
HETATM 5457 H H1     . HOH E 4 .   ? 34.721  -16.977 -0.502  1    35.391 ? 1611 HOH A H1     1 ? 
HETATM 5458 H H2     . HOH E 4 .   ? 35.284  -15.577 -0.939  1    36.819 ? 1611 HOH A H2     1 ? 
HETATM 5459 O O      . HOH E 4 .   ? 21.251  -21.58  16.117  1    18.939 ? 1612 HOH A O      1 ? 
HETATM 5460 H H1     . HOH E 4 .   ? 21.802  -21.772 16.883  1    18.391 ? 1612 HOH A H1     1 ? 
HETATM 5461 H H2     . HOH E 4 .   ? 20.557  -20.958 16.431  1    18.417 ? 1612 HOH A H2     1 ? 
HETATM 5462 O O      . HOH E 4 .   ? 30.615  -10.59  -0.952  1    27.164 ? 1613 HOH A O      1 ? 
HETATM 5463 H H1     . HOH E 4 .   ? 30.664  -9.635  -1.21   1    27.196 ? 1613 HOH A H1     1 ? 
HETATM 5464 H H2     . HOH E 4 .   ? 30.204  -10.669 -0.063  1    23.93  ? 1613 HOH A H2     1 ? 
HETATM 5465 O O      . HOH E 4 .   ? 8.413   -10.388 15.718  1    23.128 ? 1614 HOH A O      1 ? 
HETATM 5466 H H1     . HOH E 4 .   ? 8.318   -9.474  16.022  1    22.118 ? 1614 HOH A H1     1 ? 
HETATM 5467 H H2     . HOH E 4 .   ? 7.522   -10.747 15.609  1    22.636 ? 1614 HOH A H2     1 ? 
HETATM 5468 O O      . HOH E 4 .   ? 34.563  -15.072 13.184  1    19.97  ? 1615 HOH A O      1 ? 
HETATM 5469 H H1     . HOH E 4 .   ? 34.463  -16.001 13.483  1    19.44  ? 1615 HOH A H1     1 ? 
HETATM 5470 H H2     . HOH E 4 .   ? 33.852  -14.517 13.599  1    19.622 ? 1615 HOH A H2     1 ? 
HETATM 5471 O O      . HOH E 4 .   ? -17.034 -13.021 11.635  1    57.973 ? 1616 HOH A O      1 ? 
HETATM 5472 H H1     . HOH E 4 .   ? -16.95  -13.936 11.307  1    55.768 ? 1616 HOH A H1     1 ? 
HETATM 5473 H H2     . HOH E 4 .   ? -17.953 -12.9   11.939  1    55.163 ? 1616 HOH A H2     1 ? 
HETATM 5474 O O      . HOH E 4 .   ? 7.437   -6.804  7.691   1    36.582 ? 1617 HOH A O      1 ? 
HETATM 5475 H H1     . HOH E 4 .   ? 6.819   -7.383  8.181   1    39.99  ? 1617 HOH A H1     1 ? 
HETATM 5476 H H2     . HOH E 4 .   ? 6.923   -6.306  7.012   1    35.583 ? 1617 HOH A H2     1 ? 
HETATM 5477 O O      . HOH E 4 .   ? 20.493  -8.297  -16.274 1    25.508 ? 1618 HOH A O      1 ? 
HETATM 5478 H H1     . HOH E 4 .   ? 19.631  -7.877  -16.436 1    25.601 ? 1618 HOH A H1     1 ? 
HETATM 5479 H H2     . HOH E 4 .   ? 20.493  -9.129  -16.777 1    25.729 ? 1618 HOH A H2     1 ? 
HETATM 5480 O O      . HOH E 4 .   ? 40.956  -19.374 12.021  1    37.137 ? 1619 HOH A O      1 ? 
HETATM 5481 H H1     . HOH E 4 .   ? 40.116  -19.508 11.543  1    36.493 ? 1619 HOH A H1     1 ? 
HETATM 5482 H H2     . HOH E 4 .   ? 40.789  -19.542 12.965  1    38.899 ? 1619 HOH A H2     1 ? 
HETATM 5483 O O      . HOH E 4 .   ? 31.087  -19.252 5.982   1    16.6   ? 1620 HOH A O      1 ? 
HETATM 5484 H H1     . HOH E 4 .   ? 30.842  -20.167 6.119   1    17.501 ? 1620 HOH A H1     1 ? 
HETATM 5485 H H2     . HOH E 4 .   ? 31.966  -19.362 5.698   1    17.451 ? 1620 HOH A H2     1 ? 
HETATM 5486 O O      . HOH E 4 .   ? 7.412   -32.904 16.029  1    65.391 ? 1621 HOH A O      1 ? 
HETATM 5487 H H1     . HOH E 4 .   ? 6.628   -33.496 16.042  1    61.575 ? 1621 HOH A H1     1 ? 
HETATM 5488 H H2     . HOH E 4 .   ? 7.363   -32.294 16.794  1    61.348 ? 1621 HOH A H2     1 ? 
HETATM 5489 O O      . HOH E 4 .   ? 3.909   -31.535 17.009  1    27.189 ? 1622 HOH A O      1 ? 
HETATM 5490 H H1     . HOH E 4 .   ? 4.709   -31.734 17.528  1    24.723 ? 1622 HOH A H1     1 ? 
HETATM 5491 H H2     . HOH E 4 .   ? 3.805   -30.557 16.969  1    25.124 ? 1622 HOH A H2     1 ? 
HETATM 5492 O O      . HOH E 4 .   ? 21.264  -40.456 18.763  1    58.816 ? 1623 HOH A O      1 ? 
HETATM 5493 H H1     . HOH E 4 .   ? 20.904  -40.86  19.584  1    59.58  ? 1623 HOH A H1     1 ? 
HETATM 5494 H H2     . HOH E 4 .   ? 22.233  -40.368 18.857  1    52.676 ? 1623 HOH A H2     1 ? 
HETATM 5495 O O      . HOH E 4 .   ? 10.351  -22.128 -16.594 1    41.888 ? 1624 HOH A O      1 ? 
HETATM 5496 H H1     . HOH E 4 .   ? 11.312  -22.245 -16.740 1    44.766 ? 1624 HOH A H1     1 ? 
HETATM 5497 H H2     . HOH E 4 .   ? 10.247  -21.512 -15.852 1    41.116 ? 1624 HOH A H2     1 ? 
HETATM 5498 O O      . HOH E 4 .   ? 26.645  -21.857 -11.002 1    31.811 ? 1625 HOH A O      1 ? 
HETATM 5499 H H1     . HOH E 4 .   ? 27.348  -22.441 -10.647 1    31.687 ? 1625 HOH A H1     1 ? 
HETATM 5500 H H2     . HOH E 4 .   ? 26.551  -22.025 -11.96  1    30.921 ? 1625 HOH A H2     1 ? 
HETATM 5501 O O      . HOH E 4 .   ? 7.411   -12.511 3.038   1    20.97  ? 1626 HOH A O      1 ? 
HETATM 5502 H H1     . HOH E 4 .   ? 7.334   -13.326 2.476   1    20.355 ? 1626 HOH A H1     1 ? 
HETATM 5503 H H2     . HOH E 4 .   ? 7.563   -11.715 2.474   1    21.423 ? 1626 HOH A H2     1 ? 
HETATM 5504 O O      . HOH E 4 .   ? 5.843   -9.763  -4.158  1    43.661 ? 1627 HOH A O      1 ? 
HETATM 5505 H H1     . HOH E 4 .   ? 6.713   -10.194 -4.097  1    44.318 ? 1627 HOH A H1     1 ? 
HETATM 5506 H H2     . HOH E 4 .   ? 5.994   -8.944  -4.666  1    43.105 ? 1627 HOH A H2     1 ? 
HETATM 5507 O O      . HOH E 4 .   ? -0.671  -29.884 17.371  1    27.61  ? 1628 HOH A O      1 ? 
HETATM 5508 H H1     . HOH E 4 .   ? -0.48   -29.067 17.868  1    27.128 ? 1628 HOH A H1     1 ? 
HETATM 5509 H H2     . HOH E 4 .   ? -1.5    -29.726 16.887  1    27.143 ? 1628 HOH A H2     1 ? 
HETATM 5510 O O      . HOH E 4 .   ? 15.339  -15.428 28.756  1    14.318 ? 1629 HOH A O      1 ? 
HETATM 5511 H H1     . HOH E 4 .   ? 15.282  -14.479 28.842  1    13.058 ? 1629 HOH A H1     1 ? 
HETATM 5512 H H2     . HOH E 4 .   ? 14.515  -15.732 28.316  1    14.918 ? 1629 HOH A H2     1 ? 
HETATM 5513 O O      . HOH E 4 .   ? 7.497   -26.931 8.206   1    38.389 ? 1630 HOH A O      1 ? 
HETATM 5514 H H1     . HOH E 4 .   ? 7.079   -26.366 7.53    1    37.567 ? 1630 HOH A H1     1 ? 
HETATM 5515 H H2     . HOH E 4 .   ? 6.775   -27.366 8.71    1    38.545 ? 1630 HOH A H2     1 ? 
HETATM 5516 O O      . HOH E 4 .   ? 36.541  -6.303  7.221   1    38.836 ? 1631 HOH A O      1 ? 
HETATM 5517 H H1     . HOH E 4 .   ? 37.335  -5.818  7.524   1    37.06  ? 1631 HOH A H1     1 ? 
HETATM 5518 H H2     . HOH E 4 .   ? 36.777  -6.768  6.393   1    35.833 ? 1631 HOH A H2     1 ? 
HETATM 5519 O O      . HOH E 4 .   ? 1.316   -12.82  26.688  1    44.415 ? 1632 HOH A O      1 ? 
HETATM 5520 H H1     . HOH E 4 .   ? 0.881   -13.279 27.429  1    44.411 ? 1632 HOH A H1     1 ? 
HETATM 5521 H H2     . HOH E 4 .   ? 2.184   -12.52  27.006  1    43.545 ? 1632 HOH A H2     1 ? 
HETATM 5522 O O      . HOH E 4 .   ? 20.528  -25.938 -1.316  1    31.162 ? 1633 HOH A O      1 ? 
HETATM 5523 H H1     . HOH E 4 .   ? 21.202  -26.134 -0.641  1    31.692 ? 1633 HOH A H1     1 ? 
HETATM 5524 H H2     . HOH E 4 .   ? 20.019  -25.177 -0.971  1    30.358 ? 1633 HOH A H2     1 ? 
HETATM 5525 O O      . HOH E 4 .   ? 38.025  -17.555 1.282   1    35.934 ? 1634 HOH A O      1 ? 
HETATM 5526 H H1     . HOH E 4 .   ? 37.134  -17.858 1.514   1    36.35  ? 1634 HOH A H1     1 ? 
HETATM 5527 H H2     . HOH E 4 .   ? 38.61   -18.322 1.444   1    35.326 ? 1634 HOH A H2     1 ? 
HETATM 5528 O O      . HOH E 4 .   ? 23.582  0.204   -1.551  1    39.644 ? 1635 HOH A O      1 ? 
HETATM 5529 H H1     . HOH E 4 .   ? 23.495  0.512   -0.617  1    35.965 ? 1635 HOH A H1     1 ? 
HETATM 5530 H H2     . HOH E 4 .   ? 24.151  -0.593  -1.597  1    34.599 ? 1635 HOH A H2     1 ? 
HETATM 5531 O O      . HOH E 4 .   ? 26.791  -29.424 35.401  1    29.812 ? 1636 HOH A O      1 ? 
HETATM 5532 H H1     . HOH E 4 .   ? 27.093  -30.203 34.883  1    28.72  ? 1636 HOH A H1     1 ? 
HETATM 5533 H H2     . HOH E 4 .   ? 27.438  -28.706 35.279  1    29.955 ? 1636 HOH A H2     1 ? 
HETATM 5534 O O      . HOH E 4 .   ? 35.902  -23.228 8.748   1    29.735 ? 1637 HOH A O      1 ? 
HETATM 5535 H H1     . HOH E 4 .   ? 35.78   -22.641 7.98    1    30.246 ? 1637 HOH A H1     1 ? 
HETATM 5536 H H2     . HOH E 4 .   ? 36.278  -22.693 9.468   1    31.489 ? 1637 HOH A H2     1 ? 
HETATM 5537 O O      . HOH E 4 .   ? 15.983  -23.669 12.53   1    37.826 ? 1638 HOH A O      1 ? 
HETATM 5538 H H1     . HOH E 4 .   ? 15.411  -23.599 11.702  1    31.962 ? 1638 HOH A H1     1 ? 
HETATM 5539 H H2     . HOH E 4 .   ? 16.92   -23.324 12.428  1    32.783 ? 1638 HOH A H2     1 ? 
HETATM 5540 O O      . HOH E 4 .   ? 32.613  -14.473 -5.778  1    44.129 ? 1639 HOH A O      1 ? 
HETATM 5541 H H1     . HOH E 4 .   ? 32.032  -15.254 -5.688  1    42.605 ? 1639 HOH A H1     1 ? 
HETATM 5542 H H2     . HOH E 4 .   ? 32.866  -14.401 -6.72   1    42.868 ? 1639 HOH A H2     1 ? 
HETATM 5543 O O      . HOH E 4 .   ? -12.19  -23.738 16.592  1    30.435 ? 1640 HOH A O      1 ? 
HETATM 5544 H H1     . HOH E 4 .   ? -11.756 -23.998 17.416  1    32.68  ? 1640 HOH A H1     1 ? 
HETATM 5545 H H2     . HOH E 4 .   ? -11.523 -23.277 16.077  1    32.068 ? 1640 HOH A H2     1 ? 
HETATM 5546 O O      . HOH E 4 .   ? -0.555  -29.299 28.731  1    16.828 ? 1641 HOH A O      1 ? 
HETATM 5547 H H1     . HOH E 4 .   ? 0.176   -29.961 28.831  1    16.494 ? 1641 HOH A H1     1 ? 
HETATM 5548 H H2     . HOH E 4 .   ? -1.196  -29.395 29.463  1    16.038 ? 1641 HOH A H2     1 ? 
HETATM 5549 O O      . HOH E 4 .   ? 7.043   -24.358 32.824  1    15.207 ? 1642 HOH A O      1 ? 
HETATM 5550 H H1     . HOH E 4 .   ? 7.497   -24.247 31.979  1    16.354 ? 1642 HOH A H1     1 ? 
HETATM 5551 H H2     . HOH E 4 .   ? 7.536   -23.838 33.43   1    16.699 ? 1642 HOH A H2     1 ? 
HETATM 5552 O O      . HOH E 4 .   ? 6.224   -28.648 15.562  1    23.006 ? 1643 HOH A O      1 ? 
HETATM 5553 H H1     . HOH E 4 .   ? 6.583   -27.787 15.915  1    21.577 ? 1643 HOH A H1     1 ? 
HETATM 5554 H H2     . HOH E 4 .   ? 6.833   -29.061 14.888  1    21.682 ? 1643 HOH A H2     1 ? 
HETATM 5555 O O      . HOH E 4 .   ? 4.649   -22.797 31.9    1    11.918 ? 1644 HOH A O      1 ? 
HETATM 5556 H H1     . HOH E 4 .   ? 5.143   -23.517 32.304  1    13.115 ? 1644 HOH A H1     1 ? 
HETATM 5557 H H2     . HOH E 4 .   ? 5.002   -22.777 30.966  1    12.703 ? 1644 HOH A H2     1 ? 
HETATM 5558 O O      . HOH E 4 .   ? 30.386  -26.526 7.4     1    18.933 ? 1645 HOH A O      1 ? 
HETATM 5559 H H1     . HOH E 4 .   ? 30.912  -26.633 6.581   1    19.542 ? 1645 HOH A H1     1 ? 
HETATM 5560 H H2     . HOH E 4 .   ? 31.003  -26.235 8.101   1    19.631 ? 1645 HOH A H2     1 ? 
HETATM 5561 O O      . HOH E 4 .   ? 29.803  -20.49  17.996  1    12.821 ? 1646 HOH A O      1 ? 
HETATM 5562 H H1     . HOH E 4 .   ? 29.765  -19.906 18.771  1    13.176 ? 1646 HOH A H1     1 ? 
HETATM 5563 H H2     . HOH E 4 .   ? 28.989  -20.992 18.06   1    13.929 ? 1646 HOH A H2     1 ? 
HETATM 5564 O O      . HOH E 4 .   ? 25.128  -24.797 24.821  1    11.479 ? 1647 HOH A O      1 ? 
HETATM 5565 H H1     . HOH E 4 .   ? 25.764  -24.629 24.153  1    11.126 ? 1647 HOH A H1     1 ? 
HETATM 5566 H H2     . HOH E 4 .   ? 24.728  -23.945 25.02   1    11.209 ? 1647 HOH A H2     1 ? 
HETATM 5567 O O      . HOH E 4 .   ? 29.411  -27.745 28.212  1    19.134 ? 1648 HOH A O      1 ? 
HETATM 5568 H H1     . HOH E 4 .   ? 30.152  -27.795 28.845  1    18.891 ? 1648 HOH A H1     1 ? 
HETATM 5569 H H2     . HOH E 4 .   ? 29.483  -26.899 27.746  1    18.565 ? 1648 HOH A H2     1 ? 
HETATM 5570 O O      . HOH E 4 .   ? 4.995   -26.358 10.793  1    44.381 ? 1649 HOH A O      1 ? 
HETATM 5571 H H1     . HOH E 4 .   ? 5.26    -27.039 10.137  1    43.682 ? 1649 HOH A H1     1 ? 
HETATM 5572 H H2     . HOH E 4 .   ? 4.885   -26.803 11.652  1    42.291 ? 1649 HOH A H2     1 ? 
HETATM 5573 O O      . HOH E 4 .   ? 23.995  -17.706 22.205  1    10.945 ? 1650 HOH A O      1 ? 
HETATM 5574 H H1     . HOH E 4 .   ? 24.836  -17.463 22.591  1    11.345 ? 1650 HOH A H1     1 ? 
HETATM 5575 H H2     . HOH E 4 .   ? 23.376  -17.5   22.923  1    12.268 ? 1650 HOH A H2     1 ? 
HETATM 5576 O O      . HOH E 4 .   ? 20.398  -11.289 21.961  1    18.076 ? 1651 HOH A O      1 ? 
HETATM 5577 H H1     . HOH E 4 .   ? 21.266  -10.903 21.776  1    18.056 ? 1651 HOH A H1     1 ? 
HETATM 5578 H H2     . HOH E 4 .   ? 19.921  -10.651 22.502  1    16.864 ? 1651 HOH A H2     1 ? 
HETATM 5579 O O      . HOH E 4 .   ? 20.733  -26.014 -13.193 1    25.425 ? 1652 HOH A O      1 ? 
HETATM 5580 H H1     . HOH E 4 .   ? 21.567  -25.543 -12.971 1    25.253 ? 1652 HOH A H1     1 ? 
HETATM 5581 H H2     . HOH E 4 .   ? 20.038  -25.348 -13.284 1    23.883 ? 1652 HOH A H2     1 ? 
HETATM 5582 O O      . HOH E 4 .   ? 33.917  -26.873 14.796  1    40.531 ? 1653 HOH A O      1 ? 
HETATM 5583 H H1     . HOH E 4 .   ? 33.815  -26.717 13.842  1    36.749 ? 1653 HOH A H1     1 ? 
HETATM 5584 H H2     . HOH E 4 .   ? 34.16   -26.016 15.202  1    36.054 ? 1653 HOH A H2     1 ? 
HETATM 5585 O O      . HOH E 4 .   ? 6.917   -16.639 32.018  1    21.127 ? 1654 HOH A O      1 ? 
HETATM 5586 H H1     . HOH E 4 .   ? 7.397   -17.445 32.219  1    24.075 ? 1654 HOH A H1     1 ? 
HETATM 5587 H H2     . HOH E 4 .   ? 6.607   -16.781 31.106  1    23.913 ? 1654 HOH A H2     1 ? 
HETATM 5588 O O      . HOH E 4 .   ? 16.575  -29.095 9.339   1    24.565 ? 1655 HOH A O      1 ? 
HETATM 5589 H H1     . HOH E 4 .   ? 16.143  -29.672 8.683   1    23.522 ? 1655 HOH A H1     1 ? 
HETATM 5590 H H2     . HOH E 4 .   ? 15.987  -28.339 9.518   1    24.646 ? 1655 HOH A H2     1 ? 
HETATM 5591 O O      . HOH E 4 .   ? 7.633   -26.945 33.71   1    6.69   ? 1656 HOH A O      1 ? 
HETATM 5592 H H1     . HOH E 4 .   ? 8.383   -27.343 33.247  1    6.971  ? 1656 HOH A H1     1 ? 
HETATM 5593 H H2     . HOH E 4 .   ? 7.52    -26.07  33.327  1    6.966  ? 1656 HOH A H2     1 ? 
HETATM 5594 O O      . HOH E 4 .   ? 31.533  -24.824 30.837  1    12.98  ? 1657 HOH A O      1 ? 
HETATM 5595 H H1     . HOH E 4 .   ? 31.34   -24.038 31.348  1    13.599 ? 1657 HOH A H1     1 ? 
HETATM 5596 H H2     . HOH E 4 .   ? 30.907  -24.712 30.105  1    14.778 ? 1657 HOH A H2     1 ? 
HETATM 5597 O O      . HOH E 4 .   ? 31.064  -27.169 13.765  1    27.597 ? 1658 HOH A O      1 ? 
HETATM 5598 H H1     . HOH E 4 .   ? 31.658  -27.863 14.124  1    26.113 ? 1658 HOH A H1     1 ? 
HETATM 5599 H H2     . HOH E 4 .   ? 31.085  -27.212 12.788  1    26.342 ? 1658 HOH A H2     1 ? 
HETATM 5600 O O      . HOH E 4 .   ? 16.519  -0.426  5.535   1    27.87  ? 1659 HOH A O      1 ? 
HETATM 5601 H H1     . HOH E 4 .   ? 16.841  -1.293  5.219   1    26.026 ? 1659 HOH A H1     1 ? 
HETATM 5602 H H2     . HOH E 4 .   ? 16.886  0.265   4.963   1    25.068 ? 1659 HOH A H2     1 ? 
HETATM 5603 O O      . HOH E 4 .   ? 8.414   -18.824 -11.622 1    45.522 ? 1660 HOH A O      1 ? 
HETATM 5604 H H1     . HOH E 4 .   ? 8.148   -18.973 -12.553 1    48.396 ? 1660 HOH A H1     1 ? 
HETATM 5605 H H2     . HOH E 4 .   ? 9.377   -18.688 -11.588 1    40.41  ? 1660 HOH A H2     1 ? 
HETATM 5606 O O      . HOH E 4 .   ? 35.919  -15.915 15.912  1    16.005 ? 1661 HOH A O      1 ? 
HETATM 5607 H H1     . HOH E 4 .   ? 35.804  -16.783 15.488  1    17.168 ? 1661 HOH A H1     1 ? 
HETATM 5608 H H2     . HOH E 4 .   ? 35.071  -15.5   15.794  1    16.634 ? 1661 HOH A H2     1 ? 
HETATM 5609 O O      . HOH E 4 .   ? 23.431  -12.248 16.879  1    13.304 ? 1662 HOH A O      1 ? 
HETATM 5610 H H1     . HOH E 4 .   ? 23.472  -13.246 16.913  1    12.625 ? 1662 HOH A H1     1 ? 
HETATM 5611 H H2     . HOH E 4 .   ? 23.191  -11.912 17.765  1    13.833 ? 1662 HOH A H2     1 ? 
HETATM 5612 O O      . HOH E 4 .   ? 14.429  -31.216 12.678  1    26.065 ? 1663 HOH A O      1 ? 
HETATM 5613 H H1     . HOH E 4 .   ? 14.586  -31.751 11.883  1    24.984 ? 1663 HOH A H1     1 ? 
HETATM 5614 H H2     . HOH E 4 .   ? 14.792  -31.713 13.457  1    25.556 ? 1663 HOH A H2     1 ? 
HETATM 5615 O O      . HOH E 4 .   ? 3.52    -35.015 27.596  1    22.791 ? 1664 HOH A O      1 ? 
HETATM 5616 H H1     . HOH E 4 .   ? 2.654   -34.909 28.005  1    24.028 ? 1664 HOH A H1     1 ? 
HETATM 5617 H H2     . HOH E 4 .   ? 3.71    -34.131 27.275  1    25.731 ? 1664 HOH A H2     1 ? 
HETATM 5618 O O      . HOH E 4 .   ? 15.17   -28.776 12.507  1    30.974 ? 1665 HOH A O      1 ? 
HETATM 5619 H H1     . HOH E 4 .   ? 15.145  -28.145 11.778  1    31.505 ? 1665 HOH A H1     1 ? 
HETATM 5620 H H2     . HOH E 4 .   ? 14.582  -29.535 12.269  1    29.213 ? 1665 HOH A H2     1 ? 
HETATM 5621 O O      . HOH E 4 .   ? 27.735  -15.005 30.616  1    33.913 ? 1666 HOH A O      1 ? 
HETATM 5622 H H1     . HOH E 4 .   ? 28.429  -15.606 30.957  1    33.168 ? 1666 HOH A H1     1 ? 
HETATM 5623 H H2     . HOH E 4 .   ? 26.964  -15.051 31.207  1    32.233 ? 1666 HOH A H2     1 ? 
HETATM 5624 O O      . HOH E 4 .   ? 8.081   -9.16   6.143   1    22.578 ? 1667 HOH A O      1 ? 
HETATM 5625 H H1     . HOH E 4 .   ? 7.651   -8.604  6.815   1    23.666 ? 1667 HOH A H1     1 ? 
HETATM 5626 H H2     . HOH E 4 .   ? 7.445   -9.869  5.982   1    22.788 ? 1667 HOH A H2     1 ? 
HETATM 5627 O O      . HOH E 4 .   ? 5.527   -20.811 14.941  1    24.726 ? 1668 HOH A O      1 ? 
HETATM 5628 H H1     . HOH E 4 .   ? 5.545   -19.966 15.415  1    25.236 ? 1668 HOH A H1     1 ? 
HETATM 5629 H H2     . HOH E 4 .   ? 4.615   -21.108 14.862  1    24.268 ? 1668 HOH A H2     1 ? 
HETATM 5630 O O      . HOH E 4 .   ? 13.628  -34.527 18.682  1    23.069 ? 1669 HOH A O      1 ? 
HETATM 5631 H H1     . HOH E 4 .   ? 13.036  -35.315 18.639  1    24.593 ? 1669 HOH A H1     1 ? 
HETATM 5632 H H2     . HOH E 4 .   ? 13.145  -33.803 18.259  1    23.675 ? 1669 HOH A H2     1 ? 
HETATM 5633 O O      . HOH E 4 .   ? 39.292  -23.776 18.658  1    30.027 ? 1670 HOH A O      1 ? 
HETATM 5634 H H1     . HOH E 4 .   ? 38.794  -23.457 17.884  1    30.911 ? 1670 HOH A H1     1 ? 
HETATM 5635 H H2     . HOH E 4 .   ? 39.429  -24.73  18.55   1    30.372 ? 1670 HOH A H2     1 ? 
HETATM 5636 O O      . HOH E 4 .   ? 33.466  -8.043  18.613  1    36.623 ? 1671 HOH A O      1 ? 
HETATM 5637 H H1     . HOH E 4 .   ? 32.831  -8.77   18.517  1    34.318 ? 1671 HOH A H1     1 ? 
HETATM 5638 H H2     . HOH E 4 .   ? 33.26   -7.407  17.908  1    39.984 ? 1671 HOH A H2     1 ? 
HETATM 5639 O O      . HOH E 4 .   ? 4.342   -16.996 -5.253  1    30.844 ? 1672 HOH A O      1 ? 
HETATM 5640 H H1     . HOH E 4 .   ? 4.43    -17.964 -5.124  1    29.878 ? 1672 HOH A H1     1 ? 
HETATM 5641 H H2     . HOH E 4 .   ? 4.997   -16.54  -4.665  1    32.953 ? 1672 HOH A H2     1 ? 
HETATM 5642 O O      . HOH E 4 .   ? 6.409   -18.357 14.716  1    16.651 ? 1673 HOH A O      1 ? 
HETATM 5643 H H1     . HOH E 4 .   ? 7.353   -18.107 14.819  1    16.014 ? 1673 HOH A H1     1 ? 
HETATM 5644 H H2     . HOH E 4 .   ? 5.961   -17.499 14.743  1    17.822 ? 1673 HOH A H2     1 ? 
HETATM 5645 O O      . HOH E 4 .   ? 25.45   -25.877 1.083   1    29.598 ? 1674 HOH A O      1 ? 
HETATM 5646 H H1     . HOH E 4 .   ? 25.456  -25.206 0.343   1    32.72  ? 1674 HOH A H1     1 ? 
HETATM 5647 H H2     . HOH E 4 .   ? 26.365  -26.149 1.294   1    29.021 ? 1674 HOH A H2     1 ? 
HETATM 5648 O O      . HOH E 4 .   ? 28.259  -26.075 10.321  1    22.468 ? 1675 HOH A O      1 ? 
HETATM 5649 H H1     . HOH E 4 .   ? 28.095  -25.568 9.518   1    20.98  ? 1675 HOH A H1     1 ? 
HETATM 5650 H H2     . HOH E 4 .   ? 27.477  -25.908 10.874  1    23.495 ? 1675 HOH A H2     1 ? 
HETATM 5651 O O      . HOH E 4 .   ? 3.518   -18.206 34.391  1    19.765 ? 1676 HOH A O      1 ? 
HETATM 5652 H H1     . HOH E 4 .   ? 4.152   -18.678 33.811  1    19.985 ? 1676 HOH A H1     1 ? 
HETATM 5653 H H2     . HOH E 4 .   ? 3.414   -17.331 33.998  1    19.893 ? 1676 HOH A H2     1 ? 
HETATM 5654 O O      . HOH E 4 .   ? -3.144  -30.776 25.651  1    26.407 ? 1677 HOH A O      1 ? 
HETATM 5655 H H1     . HOH E 4 .   ? -3.367  -30.004 26.205  1    25.883 ? 1677 HOH A H1     1 ? 
HETATM 5656 H H2     . HOH E 4 .   ? -3.652  -30.705 24.826  1    27.471 ? 1677 HOH A H2     1 ? 
HETATM 5657 O O      . HOH E 4 .   ? 13.91   -8.069  21.226  1    17.533 ? 1678 HOH A O      1 ? 
HETATM 5658 H H1     . HOH E 4 .   ? 12.947  -8.047  21.341  1    17.989 ? 1678 HOH A H1     1 ? 
HETATM 5659 H H2     . HOH E 4 .   ? 14.275  -7.8    22.076  1    17.788 ? 1678 HOH A H2     1 ? 
HETATM 5660 O O      . HOH E 4 .   ? -17.427 -15.845 20.508  1    30.207 ? 1679 HOH A O      1 ? 
HETATM 5661 H H1     . HOH E 4 .   ? -17.412 -16.735 20.919  1    30.001 ? 1679 HOH A H1     1 ? 
HETATM 5662 H H2     . HOH E 4 .   ? -17.966 -15.275 21.081  1    30.317 ? 1679 HOH A H2     1 ? 
HETATM 5663 O O      . HOH E 4 .   ? 27.279  -28.367 25.081  1    16.471 ? 1680 HOH A O      1 ? 
HETATM 5664 H H1     . HOH E 4 .   ? 27.406  -27.65  25.705  1    17.853 ? 1680 HOH A H1     1 ? 
HETATM 5665 H H2     . HOH E 4 .   ? 27.095  -27.915 24.229  1    17.773 ? 1680 HOH A H2     1 ? 
HETATM 5666 O O      . HOH E 4 .   ? 10.063  -22.766 39.157  1    15.351 ? 1681 HOH A O      1 ? 
HETATM 5667 H H1     . HOH E 4 .   ? 10.88   -22.322 38.937  1    16.475 ? 1681 HOH A H1     1 ? 
HETATM 5668 H H2     . HOH E 4 .   ? 9.851   -23.245 38.356  1    16.914 ? 1681 HOH A H2     1 ? 
HETATM 5669 O O      . HOH E 4 .   ? 13.667  -4.394  -9.325  1    38.42  ? 1682 HOH A O      1 ? 
HETATM 5670 H H1     . HOH E 4 .   ? 13.897  -5.022  -10.043 1    38.46  ? 1682 HOH A H1     1 ? 
HETATM 5671 H H2     . HOH E 4 .   ? 14.428  -4.323  -8.721  1    33.469 ? 1682 HOH A H2     1 ? 
HETATM 5672 O O      . HOH E 4 .   ? 37.155  -18.246 23.416  1    18.168 ? 1683 HOH A O      1 ? 
HETATM 5673 H H1     . HOH E 4 .   ? 36.875  -19.092 23.815  1    18.931 ? 1683 HOH A H1     1 ? 
HETATM 5674 H H2     . HOH E 4 .   ? 36.682  -18.172 22.564  1    17.367 ? 1683 HOH A H2     1 ? 
HETATM 5675 O O      . HOH E 4 .   ? 15.074  -26.435 39.188  1    30.04  ? 1684 HOH A O      1 ? 
HETATM 5676 H H1     . HOH E 4 .   ? 15.784  -25.941 39.682  1    26.061 ? 1684 HOH A H1     1 ? 
HETATM 5677 H H2     . HOH E 4 .   ? 14.171  -26.248 39.547  1    26.806 ? 1684 HOH A H2     1 ? 
HETATM 5678 O O      . HOH E 4 .   ? 0.513   -22.262 15.83   1    21.351 ? 1685 HOH A O      1 ? 
HETATM 5679 H H1     . HOH E 4 .   ? 0.947   -21.394 15.902  1    21.432 ? 1685 HOH A H1     1 ? 
HETATM 5680 H H2     . HOH E 4 .   ? 0.98    -22.754 15.133  1    20.869 ? 1685 HOH A H2     1 ? 
HETATM 5681 O O      . HOH E 4 .   ? 31.416  -21.899 3.198   1    17.341 ? 1686 HOH A O      1 ? 
HETATM 5682 H H1     . HOH E 4 .   ? 30.855  -21.705 3.946   1    17.645 ? 1686 HOH A H1     1 ? 
HETATM 5683 H H2     . HOH E 4 .   ? 30.79   -22.057 2.484   1    18.945 ? 1686 HOH A H2     1 ? 
HETATM 5684 O O      . HOH E 4 .   ? 38.917  -28.804 18.392  1    42.373 ? 1687 HOH A O      1 ? 
HETATM 5685 H H1     . HOH E 4 .   ? 39.588  -29.397 18.002  1    40.16  ? 1687 HOH A H1     1 ? 
HETATM 5686 H H2     . HOH E 4 .   ? 38.996  -27.94  17.948  1    40.991 ? 1687 HOH A H2     1 ? 
HETATM 5687 O O      . HOH E 4 .   ? 28.689  -30.55  25.678  1    20.995 ? 1688 HOH A O      1 ? 
HETATM 5688 H H1     . HOH E 4 .   ? 27.997  -30.953 26.221  1    21.39  ? 1688 HOH A H1     1 ? 
HETATM 5689 H H2     . HOH E 4 .   ? 28.388  -29.638 25.48   1    22.254 ? 1688 HOH A H2     1 ? 
HETATM 5690 O O      . HOH E 4 .   ? 19.024  -23.639 -14.452 1    26.373 ? 1689 HOH A O      1 ? 
HETATM 5691 H H1     . HOH E 4 .   ? 19.935  -23.968 -14.52  1    24.481 ? 1689 HOH A H1     1 ? 
HETATM 5692 H H2     . HOH E 4 .   ? 19.02   -22.897 -13.796 1    23.329 ? 1689 HOH A H2     1 ? 
HETATM 5693 O O      . HOH E 4 .   ? -16.696 -17.131 14.723  1    30.066 ? 1690 HOH A O      1 ? 
HETATM 5694 H H1     . HOH E 4 .   ? -17.145 -17.949 15.025  1    26.721 ? 1690 HOH A H1     1 ? 
HETATM 5695 H H2     . HOH E 4 .   ? -16.401 -16.644 15.531  1    30.943 ? 1690 HOH A H2     1 ? 
HETATM 5696 O O      . HOH E 4 .   ? 34.68   -11.768 12.522  1    27.962 ? 1691 HOH A O      1 ? 
HETATM 5697 H H1     . HOH E 4 .   ? 34.313  -10.963 12.096  1    26.59  ? 1691 HOH A H1     1 ? 
HETATM 5698 H H2     . HOH E 4 .   ? 33.925  -12.2   12.969  1    26.316 ? 1691 HOH A H2     1 ? 
HETATM 5699 O O      . HOH E 4 .   ? 3.924   -13.998 1.124   1    28.044 ? 1692 HOH A O      1 ? 
HETATM 5700 H H1     . HOH E 4 .   ? 4.304   -14.793 1.539   1    26.921 ? 1692 HOH A H1     1 ? 
HETATM 5701 H H2     . HOH E 4 .   ? 4.211   -13.23  1.65    1    27.751 ? 1692 HOH A H2     1 ? 
HETATM 5702 O O      . HOH E 4 .   ? 21.391  -10.881 -16.144 1    60.11  ? 1693 HOH A O      1 ? 
HETATM 5703 H H1     . HOH E 4 .   ? 21.834  -11.367 -16.867 1    55.14  ? 1693 HOH A H1     1 ? 
HETATM 5704 H H2     . HOH E 4 .   ? 21.869  -11.059 -15.307 1    58.129 ? 1693 HOH A H2     1 ? 
HETATM 5705 O O      . HOH E 4 .   ? -4.408  -25.521 25.806  1    63.637 ? 1694 HOH A O      1 ? 
HETATM 5706 H H1     . HOH E 4 .   ? -3.583  -25.896 26.18   1    61.05  ? 1694 HOH A H1     1 ? 
HETATM 5707 H H2     . HOH E 4 .   ? -4.198  -25.017 24.99   1    59.819 ? 1694 HOH A H2     1 ? 
HETATM 5708 O O      . HOH E 4 .   ? 0.014   -24.983 27.649  1    24.606 ? 1695 HOH A O      1 ? 
HETATM 5709 H H1     . HOH E 4 .   ? 0.74    -24.786 27.05   1    23.102 ? 1695 HOH A H1     1 ? 
HETATM 5710 H H2     . HOH E 4 .   ? -0.773  -24.506 27.282  1    30.49  ? 1695 HOH A H2     1 ? 
HETATM 5711 O O      . HOH E 4 .   ? 16.916  -5.409  21.088  1    26.456 ? 1696 HOH A O      1 ? 
HETATM 5712 H H1     . HOH E 4 .   ? 17.032  -4.587  21.599  1    26.772 ? 1696 HOH A H1     1 ? 
HETATM 5713 H H2     . HOH E 4 .   ? 16      -5.372  20.75   1    26.295 ? 1696 HOH A H2     1 ? 
HETATM 5714 O O      . HOH E 4 .   ? 14.89   -36.654 18.872  1    25.178 ? 1697 HOH A O      1 ? 
HETATM 5715 H H1     . HOH E 4 .   ? 15.438  -36.966 18.114  1    24.187 ? 1697 HOH A H1     1 ? 
HETATM 5716 H H2     . HOH E 4 .   ? 15.311  -36.882 19.743  1    23.416 ? 1697 HOH A H2     1 ? 
HETATM 5717 O O      . HOH E 4 .   ? 23.732  -7.819  22.433  1    27.68  ? 1698 HOH A O      1 ? 
HETATM 5718 H H1     . HOH E 4 .   ? 24.671  -8.063  22.338  1    27.762 ? 1698 HOH A H1     1 ? 
HETATM 5719 H H2     . HOH E 4 .   ? 23.204  -8.625  22.366  1    25.875 ? 1698 HOH A H2     1 ? 
HETATM 5720 O O      . HOH E 4 .   ? 4.353   -11.461 2.169   1    30.098 ? 1699 HOH A O      1 ? 
HETATM 5721 H H1     . HOH E 4 .   ? 4.065   -11.403 3.1     1    28.839 ? 1699 HOH A H1     1 ? 
HETATM 5722 H H2     . HOH E 4 .   ? 3.555   -11.545 1.608   1    27.568 ? 1699 HOH A H2     1 ? 
HETATM 5723 O O      . HOH E 4 .   ? 36.277  -2.701  1.694   1    19.262 ? 1700 HOH A O      1 ? 
HETATM 5724 H H1     . HOH E 4 .   ? 35.440  -3.175  1.772   1    21.567 ? 1700 HOH A H1     1 ? 
HETATM 5725 H H2     . HOH E 4 .   ? 36.770  -3.036  2.443   1    19.969 ? 1700 HOH A H2     1 ? 
HETATM 5726 O O      . HOH E 4 .   ? 30.382  -22.178 0.915   1    21.311 ? 1701 HOH A O      1 ? 
HETATM 5727 H H1     . HOH E 4 .   ? 30.881  -22.933 0.533   1    20.559 ? 1701 HOH A H1     1 ? 
HETATM 5728 H H2     . HOH E 4 .   ? 30.671  -21.354 0.474   1    19.683 ? 1701 HOH A H2     1 ? 
HETATM 5729 O O      . HOH E 4 .   ? 13.249  -3.996  -17.316 1    52.797 ? 1702 HOH A O      1 ? 
HETATM 5730 H H1     . HOH E 4 .   ? 13.632  -4.605  -16.662 1    50.309 ? 1702 HOH A H1     1 ? 
HETATM 5731 H H2     . HOH E 4 .   ? 13.300  -4.426  -18.194 1    48.4   ? 1702 HOH A H2     1 ? 
HETATM 5732 O O      . HOH E 4 .   ? -10.283 -11.863 16.419  1    26.093 ? 1703 HOH A O      1 ? 
HETATM 5733 H H1     . HOH E 4 .   ? -10.071 -12.154 17.321  1    25.899 ? 1703 HOH A H1     1 ? 
HETATM 5734 H H2     . HOH E 4 .   ? -10.751 -12.601 15.988  1    26.413 ? 1703 HOH A H2     1 ? 
HETATM 5735 O O      . HOH E 4 .   ? 33.033  -17.879 28.811  1    23.563 ? 1704 HOH A O      1 ? 
HETATM 5736 H H1     . HOH E 4 .   ? 33.545  -17.394 28.125  1    24.817 ? 1704 HOH A H1     1 ? 
HETATM 5737 H H2     . HOH E 4 .   ? 32.512  -18.579 28.358  1    23.208 ? 1704 HOH A H2     1 ? 
HETATM 5738 O O      . HOH E 4 .   ? 25      -19.217 -8.671  1    27.576 ? 1705 HOH A O      1 ? 
HETATM 5739 H H1     . HOH E 4 .   ? 25.096  -19.711 -7.833  1    28.089 ? 1705 HOH A H1     1 ? 
HETATM 5740 H H2     . HOH E 4 .   ? 24.427  -18.449 -8.509  1    25.447 ? 1705 HOH A H2     1 ? 
HETATM 5741 O O      . HOH E 4 .   ? 18.302  -2.265  -7.227  1    29.655 ? 1706 HOH A O      1 ? 
HETATM 5742 H H1     . HOH E 4 .   ? 19.041  -2.67   -6.723  1    30.012 ? 1706 HOH A H1     1 ? 
HETATM 5743 H H2     . HOH E 4 .   ? 17.518  -2.188  -6.634  1    28.805 ? 1706 HOH A H2     1 ? 
HETATM 5744 O O      . HOH E 4 .   ? 38.034  -23.629 26.25   1    12.781 ? 1707 HOH A O      1 ? 
HETATM 5745 H H1     . HOH E 4 .   ? 37.746  -24.001 27.093  1    13.277 ? 1707 HOH A H1     1 ? 
HETATM 5746 H H2     . HOH E 4 .   ? 38.106  -22.682 26.45   1    13.652 ? 1707 HOH A H2     1 ? 
HETATM 5747 O O      . HOH E 4 .   ? -0.507  0.736   -6.760  1    47.727 ? 1708 HOH A O      1 ? 
HETATM 5748 H H1     . HOH E 4 .   ? -1.475  0.700   -6.887  1    43.39  ? 1708 HOH A H1     1 ? 
HETATM 5749 H H2     . HOH E 4 .   ? -0.210  1.663   -6.896  1    46.671 ? 1708 HOH A H2     1 ? 
HETATM 5750 O O      . HOH E 4 .   ? 28.11   -29.097 33.282  1    19.272 ? 1709 HOH A O      1 ? 
HETATM 5751 H H1     . HOH E 4 .   ? 27.865  -29.684 32.546  1    17.51  ? 1709 HOH A H1     1 ? 
HETATM 5752 H H2     . HOH E 4 .   ? 29.02   -28.774 33.116  1    18.232 ? 1709 HOH A H2     1 ? 
HETATM 5753 O O      . HOH E 4 .   ? -5.596  -27.58  24.614  1    36.914 ? 1710 HOH A O      1 ? 
HETATM 5754 H H1     . HOH E 4 .   ? -4.948  -27.535 25.347  1    35.581 ? 1710 HOH A H1     1 ? 
HETATM 5755 H H2     . HOH E 4 .   ? -6.442  -27.895 24.98   1    34.902 ? 1710 HOH A H2     1 ? 
HETATM 5756 O O      . HOH E 4 .   ? 22.06   -17.608 -12.679 1    27.75  ? 1711 HOH A O      1 ? 
HETATM 5757 H H1     . HOH E 4 .   ? 22.127  -17.988 -11.777 1    28.417 ? 1711 HOH A H1     1 ? 
HETATM 5758 H H2     . HOH E 4 .   ? 21.245  -17.96  -13.081 1    28.12  ? 1711 HOH A H2     1 ? 
HETATM 5759 O O      . HOH E 4 .   ? 1.397   -16.262 1.811   1    52.898 ? 1712 HOH A O      1 ? 
HETATM 5760 H H1     . HOH E 4 .   ? 0.648   -16.913 1.836   1    46.938 ? 1712 HOH A H1     1 ? 
HETATM 5761 H H2     . HOH E 4 .   ? 1.409   -15.665 2.608   1    43.569 ? 1712 HOH A H2     1 ? 
HETATM 5762 O O      . HOH E 4 .   ? 13.01   -14.884 33.667  1    20.914 ? 1713 HOH A O      1 ? 
HETATM 5763 H H1     . HOH E 4 .   ? 13.808  -14.736 34.179  1    22.139 ? 1713 HOH A H1     1 ? 
HETATM 5764 H H2     . HOH E 4 .   ? 13.17   -14.437 32.819  1    21.766 ? 1713 HOH A H2     1 ? 
HETATM 5765 O O      . HOH E 4 .   ? 28.238  -28.022 20.54   1    12.398 ? 1714 HOH A O      1 ? 
HETATM 5766 H H1     . HOH E 4 .   ? 28.641  -28.799 20.13   1    13.609 ? 1714 HOH A H1     1 ? 
HETATM 5767 H H2     . HOH E 4 .   ? 27.508  -27.853 19.946  1    12.889 ? 1714 HOH A H2     1 ? 
HETATM 5768 O O      . HOH E 4 .   ? -14.168 -20.811 21.333  1    21.061 ? 1715 HOH A O      1 ? 
HETATM 5769 H H1     . HOH E 4 .   ? -13.628 -21.272 21.988  1    20.365 ? 1715 HOH A H1     1 ? 
HETATM 5770 H H2     . HOH E 4 .   ? -13.611 -20.145 20.875  1    20.599 ? 1715 HOH A H2     1 ? 
HETATM 5771 O O      . HOH E 4 .   ? 38.211  -32.585 22.119  1    26.03  ? 1716 HOH A O      1 ? 
HETATM 5772 H H1     . HOH E 4 .   ? 38.958  -31.987 22.274  1    27.498 ? 1716 HOH A H1     1 ? 
HETATM 5773 H H2     . HOH E 4 .   ? 37.606  -32.091 21.551  1    26.614 ? 1716 HOH A H2     1 ? 
HETATM 5774 O O      . HOH E 4 .   ? 29.633  -29.698 19.023  1    23.684 ? 1717 HOH A O      1 ? 
HETATM 5775 H H1     . HOH E 4 .   ? 29.588  -30.583 19.399  1    24.421 ? 1717 HOH A H1     1 ? 
HETATM 5776 H H2     . HOH E 4 .   ? 30.546  -29.414 19.147  1    23.785 ? 1717 HOH A H2     1 ? 
HETATM 5777 O O      . HOH E 4 .   ? 24.841  -0.147  18.692  1    31.926 ? 1718 HOH A O      1 ? 
HETATM 5778 H H1     . HOH E 4 .   ? 23.875  -0.115  18.523  1    31.948 ? 1718 HOH A H1     1 ? 
HETATM 5779 H H2     . HOH E 4 .   ? 25.097  0.685   19.122  1    31.724 ? 1718 HOH A H2     1 ? 
HETATM 5780 O O      . HOH E 4 .   ? 34.054  -4.342  9.664   1    14.53  ? 1719 HOH A O      1 ? 
HETATM 5781 H H1     . HOH E 4 .   ? 34.056  -5.249  9.33    1    15.757 ? 1719 HOH A H1     1 ? 
HETATM 5782 H H2     . HOH E 4 .   ? 34.869  -4.246  10.172  1    15.244 ? 1719 HOH A H2     1 ? 
HETATM 5783 O O      . HOH E 4 .   ? 4.969   -27.131 13.319  1    38.865 ? 1720 HOH A O      1 ? 
HETATM 5784 H H1     . HOH E 4 .   ? 5.502   -27.85  13.705  1    36.461 ? 1720 HOH A H1     1 ? 
HETATM 5785 H H2     . HOH E 4 .   ? 5.18    -26.31  13.805  1    38.247 ? 1720 HOH A H2     1 ? 
HETATM 5786 O O      . HOH E 4 .   ? 24.427  -36.794 26.389  1    35.714 ? 1721 HOH A O      1 ? 
HETATM 5787 H H1     . HOH E 4 .   ? 24.842  -37.249 25.628  1    34.976 ? 1721 HOH A H1     1 ? 
HETATM 5788 H H2     . HOH E 4 .   ? 24.343  -35.844 26.177  1    32.653 ? 1721 HOH A H2     1 ? 
HETATM 5789 O O      . HOH E 4 .   ? -6.427  -20.999 14.801  1    37.068 ? 1722 HOH A O      1 ? 
HETATM 5790 H H1     . HOH E 4 .   ? -6.087  -20.389 15.489  1    37.266 ? 1722 HOH A H1     1 ? 
HETATM 5791 H H2     . HOH E 4 .   ? -6.73   -21.814 15.254  1    34.974 ? 1722 HOH A H2     1 ? 
HETATM 5792 O O      . HOH E 4 .   ? 8.006   -30.731 32.609  1    39.081 ? 1723 HOH A O      1 ? 
HETATM 5793 H H1     . HOH E 4 .   ? 8.529   -29.923 32.444  1    37.542 ? 1723 HOH A H1     1 ? 
HETATM 5794 H H2     . HOH E 4 .   ? 7.333   -30.81  31.899  1    33.798 ? 1723 HOH A H2     1 ? 
HETATM 5795 O O      . HOH E 4 .   ? 10.992  -19.025 39.752  1    23.847 ? 1724 HOH A O      1 ? 
HETATM 5796 H H1     . HOH E 4 .   ? 11.44   -19.681 39.184  1    23.099 ? 1724 HOH A H1     1 ? 
HETATM 5797 H H2     . HOH E 4 .   ? 11.485  -18.181 39.735  1    23.627 ? 1724 HOH A H2     1 ? 
HETATM 5798 O O      . HOH E 4 .   ? 1.313   -1.241  14.218  1    36.017 ? 1725 HOH A O      1 ? 
HETATM 5799 H H1     . HOH E 4 .   ? 1.074   -0.437  14.712  1    35.056 ? 1725 HOH A H1     1 ? 
HETATM 5800 H H2     . HOH E 4 .   ? 0.616   -1.938  14.371  1    33.929 ? 1725 HOH A H2     1 ? 
HETATM 5801 O O      . HOH E 4 .   ? 21.154  -29.874 -4.339  1    54.624 ? 1726 HOH A O      1 ? 
HETATM 5802 H H1     . HOH E 4 .   ? 22.095  -29.744 -4.569  1    54.379 ? 1726 HOH A H1     1 ? 
HETATM 5803 H H2     . HOH E 4 .   ? 20.64   -29.989 -5.161  1    52.527 ? 1726 HOH A H2     1 ? 
HETATM 5804 O O      . HOH E 4 .   ? 20.964  -38.623 30.496  1    27.066 ? 1727 HOH A O      1 ? 
HETATM 5805 H H1     . HOH E 4 .   ? 21.544  -37.961 30.923  1    25.596 ? 1727 HOH A H1     1 ? 
HETATM 5806 H H2     . HOH E 4 .   ? 20.078  -38.2   30.473  1    26.004 ? 1727 HOH A H2     1 ? 
HETATM 5807 O O      . HOH E 4 .   ? 8.68    -7.917  -13.479 1    49.48  ? 1728 HOH A O      1 ? 
HETATM 5808 H H1     . HOH E 4 .   ? 9.621   -7.956  -13.238 1    47.803 ? 1728 HOH A H1     1 ? 
HETATM 5809 H H2     . HOH E 4 .   ? 8.517   -8.635  -14.12  1    49.8   ? 1728 HOH A H2     1 ? 
HETATM 5810 O O      . HOH E 4 .   ? 9.341   -10.219 30.288  1    36.719 ? 1729 HOH A O      1 ? 
HETATM 5811 H H1     . HOH E 4 .   ? 10.265  -10.167 30.582  1    38.622 ? 1729 HOH A H1     1 ? 
HETATM 5812 H H2     . HOH E 4 .   ? 9.057   -9.299  30.209  1    38.319 ? 1729 HOH A H2     1 ? 
HETATM 5813 O O      . HOH E 4 .   ? 31.86   -18.037 -3.941  1    42.812 ? 1730 HOH A O      1 ? 
HETATM 5814 H H1     . HOH E 4 .   ? 32.283  -18.306 -4.786  1    43.054 ? 1730 HOH A H1     1 ? 
HETATM 5815 H H2     . HOH E 4 .   ? 32.097  -17.107 -3.76   1    41.05  ? 1730 HOH A H2     1 ? 
HETATM 5816 O O      . HOH E 4 .   ? 11.614  -14.617 -14.125 1    24.221 ? 1731 HOH A O      1 ? 
HETATM 5817 H H1     . HOH E 4 .   ? 11.224  -14.127 -13.369 1    23.639 ? 1731 HOH A H1     1 ? 
HETATM 5818 H H2     . HOH E 4 .   ? 10.883  -14.815 -14.735 1    23.937 ? 1731 HOH A H2     1 ? 
HETATM 5819 O O      . HOH E 4 .   ? 13.894  -0.219  13.357  1    33.471 ? 1732 HOH A O      1 ? 
HETATM 5820 H H1     . HOH E 4 .   ? 14.092  0.303   12.557  1    29.979 ? 1732 HOH A H1     1 ? 
HETATM 5821 H H2     . HOH E 4 .   ? 14.462  0.13    14.089  1    32.622 ? 1732 HOH A H2     1 ? 
HETATM 5822 O O      . HOH E 4 .   ? -22.180 -12.723 12.152  1    35.365 ? 1733 HOH A O      1 ? 
HETATM 5823 H H1     . HOH E 4 .   ? -21.800 -12.696 11.243  1    31.031 ? 1733 HOH A H1     1 ? 
HETATM 5824 H H2     . HOH E 4 .   ? -21.462 -12.621 12.816  1    30.485 ? 1733 HOH A H2     1 ? 
HETATM 5825 O O      . HOH E 4 .   ? 28.585  -27.14  3.444   1    44.276 ? 1734 HOH A O      1 ? 
HETATM 5826 H H1     . HOH E 4 .   ? 29.28   -26.676 3.939   1    47.942 ? 1734 HOH A H1     1 ? 
HETATM 5827 H H2     . HOH E 4 .   ? 27.741  -26.874 3.859   1    46.075 ? 1734 HOH A H2     1 ? 
HETATM 5828 O O      . HOH E 4 .   ? 3.857   -22.291 13.044  1    34.638 ? 1735 HOH A O      1 ? 
HETATM 5829 H H1     . HOH E 4 .   ? 4.325   -22.627 12.235  1    32.028 ? 1735 HOH A H1     1 ? 
HETATM 5830 H H2     . HOH E 4 .   ? 3.676   -23.05  13.644  1    34.837 ? 1735 HOH A H2     1 ? 
HETATM 5831 O O      . HOH E 4 .   ? 19.82   -14.274 27.303  1    19.609 ? 1736 HOH A O      1 ? 
HETATM 5832 H H1     . HOH E 4 .   ? 20.272  -15.11  27.212  1    20.715 ? 1736 HOH A H1     1 ? 
HETATM 5833 H H2     . HOH E 4 .   ? 19.929  -13.871 26.43   1    21.612 ? 1736 HOH A H2     1 ? 
HETATM 5834 O O      . HOH E 4 .   ? 22.987  -1.175  19.898  1    34.248 ? 1737 HOH A O      1 ? 
HETATM 5835 H H1     . HOH E 4 .   ? 22.168  -0.681  19.723  1    34.65  ? 1737 HOH A H1     1 ? 
HETATM 5836 H H2     . HOH E 4 .   ? 22.885  -2.033  19.464  1    31.561 ? 1737 HOH A H2     1 ? 
HETATM 5837 O O      . HOH E 4 .   ? 19.592  -15.676 31.481  1    30.891 ? 1738 HOH A O      1 ? 
HETATM 5838 H H1     . HOH E 4 .   ? 18.674  -15.637 31.182  1    28.814 ? 1738 HOH A H1     1 ? 
HETATM 5839 H H2     . HOH E 4 .   ? 19.84   -16.621 31.46   1    32.486 ? 1738 HOH A H2     1 ? 
HETATM 5840 O O      . HOH E 4 .   ? -14.092 -18.248 22.326  1    39.531 ? 1739 HOH A O      1 ? 
HETATM 5841 H H1     . HOH E 4 .   ? -13.588 -17.863 21.575  1    36.519 ? 1739 HOH A H1     1 ? 
HETATM 5842 H H2     . HOH E 4 .   ? -13.621 -19.046 22.646  1    37.125 ? 1739 HOH A H2     1 ? 
HETATM 5843 O O      . HOH E 4 .   ? 4.729   -9.249  25.826  1    27.989 ? 1740 HOH A O      1 ? 
HETATM 5844 H H1     . HOH E 4 .   ? 5.003   -8.32   25.748  1    26.252 ? 1740 HOH A H1     1 ? 
HETATM 5845 H H2     . HOH E 4 .   ? 4.82    -9.463  26.78   1    29.263 ? 1740 HOH A H2     1 ? 
HETATM 5846 O O      . HOH E 4 .   ? 22.832  -2.24   6.122   1    20.94  ? 1741 HOH A O      1 ? 
HETATM 5847 H H1     . HOH E 4 .   ? 23.773  -2.119  5.828   1    23.636 ? 1741 HOH A H1     1 ? 
HETATM 5848 H H2     . HOH E 4 .   ? 22.669  -1.675  6.89    1    18.427 ? 1741 HOH A H2     1 ? 
HETATM 5849 O O      . HOH E 4 .   ? -12.594 -26.742 17.071  1    29.445 ? 1742 HOH A O      1 ? 
HETATM 5850 H H1     . HOH E 4 .   ? -13.133 -26.555 17.866  1    25.828 ? 1742 HOH A H1     1 ? 
HETATM 5851 H H2     . HOH E 4 .   ? -12.539 -25.922 16.519  1    27.715 ? 1742 HOH A H2     1 ? 
HETATM 5852 O O      . HOH E 4 .   ? 10.671  -25.588 4.984   1    26.246 ? 1743 HOH A O      1 ? 
HETATM 5853 H H1     . HOH E 4 .   ? 10.831  -26.447 5.397   1    23.671 ? 1743 HOH A H1     1 ? 
HETATM 5854 H H2     . HOH E 4 .   ? 10.577  -25.753 4.029   1    26     ? 1743 HOH A H2     1 ? 
HETATM 5855 O O      . HOH E 4 .   ? -20.215 -10.02  17.166  1    53.976 ? 1744 HOH A O      1 ? 
HETATM 5856 H H1     . HOH E 4 .   ? -20.341 -10.271 18.107  1    52.057 ? 1744 HOH A H1     1 ? 
HETATM 5857 H H2     . HOH E 4 .   ? -20.123 -10.836 16.63   1    52.505 ? 1744 HOH A H2     1 ? 
HETATM 5858 O O      . HOH E 4 .   ? 38.931  -26.429 19.505  1    24.495 ? 1745 HOH A O      1 ? 
HETATM 5859 H H1     . HOH E 4 .   ? 39.669  -26.06  20.025  1    23.9   ? 1745 HOH A H1     1 ? 
HETATM 5860 H H2     . HOH E 4 .   ? 38.102  -26.135 19.927  1    22.959 ? 1745 HOH A H2     1 ? 
HETATM 5861 O O      . HOH E 4 .   ? 35.488  -12.717 27.774  1    30.738 ? 1746 HOH A O      1 ? 
HETATM 5862 H H1     . HOH E 4 .   ? 35.264  -12.041 27.102  1    28.557 ? 1746 HOH A H1     1 ? 
HETATM 5863 H H2     . HOH E 4 .   ? 34.705  -12.881 28.345  1    29.117 ? 1746 HOH A H2     1 ? 
HETATM 5864 O O      . HOH E 4 .   ? 16.651  -25.784 1.024   1    43.738 ? 1747 HOH A O      1 ? 
HETATM 5865 H H1     . HOH E 4 .   ? 17.167  -25.932 1.845   1    38.673 ? 1747 HOH A H1     1 ? 
HETATM 5866 H H2     . HOH E 4 .   ? 17      -24.983 0.558   1    45.065 ? 1747 HOH A H2     1 ? 
HETATM 5867 O O      . HOH E 4 .   ? 27.905  -21.37  -5.892  1    36.415 ? 1748 HOH A O      1 ? 
HETATM 5868 H H1     . HOH E 4 .   ? 26.977  -21.529 -6.175  0.71 37.893 ? 1748 HOH A H1     1 ? 
HETATM 5869 H H2     . HOH E 4 .   ? 28.391  -22.202 -6.011  0.65 34.995 ? 1748 HOH A H2     1 ? 
HETATM 5870 O O      . HOH E 4 .   ? 6.407   -36.512 18.468  1    26.358 ? 1749 HOH A O      1 ? 
HETATM 5871 H H1     . HOH E 4 .   ? 6.393   -36.891 19.372  1    26.452 ? 1749 HOH A H1     1 ? 
HETATM 5872 H H2     . HOH E 4 .   ? 7.266   -36.77  18.089  1    26.051 ? 1749 HOH A H2     1 ? 
HETATM 5873 O O      . HOH E 4 .   ? 22.347  -10.882 25.449  1    51.235 ? 1750 HOH A O      1 ? 
HETATM 5874 H H1     . HOH E 4 .   ? 22.948  -10.167 25.741  1    48.282 ? 1750 HOH A H1     1 ? 
HETATM 5875 H H2     . HOH E 4 .   ? 21.428  -10.565 25.543  1    48.379 ? 1750 HOH A H2     1 ? 
HETATM 5876 O O      . HOH E 4 .   ? 26.779  -6.851  -5.052  1    22.945 ? 1751 HOH A O      1 ? 
HETATM 5877 H H1     . HOH E 4 .   ? 25.865  -7.182  -4.998  1    23.89  ? 1751 HOH A H1     1 ? 
HETATM 5878 H H2     . HOH E 4 .   ? 27.298  -7.558  -5.506  1    23.998 ? 1751 HOH A H2     1 ? 
HETATM 5879 O O      . HOH E 4 .   ? 5.74    0.052   17.405  1    22.053 ? 1752 HOH A O      1 ? 
HETATM 5880 H H1     . HOH E 4 .   ? 4.961   -0.495  17.638  1    22.356 ? 1752 HOH A H1     1 ? 
HETATM 5881 H H2     . HOH E 4 .   ? 5.769   0.053   16.439  1    20.81  ? 1752 HOH A H2     1 ? 
HETATM 5882 O O      . HOH E 4 .   ? 0.894   -22.987 29.545  1    21.737 ? 1753 HOH A O      1 ? 
HETATM 5883 H H1     . HOH E 4 .   ? 0.953   -23.293 30.466  1    22.664 ? 1753 HOH A H1     1 ? 
HETATM 5884 H H2     . HOH E 4 .   ? 0.696   -23.779 29.023  1    23.166 ? 1753 HOH A H2     1 ? 
HETATM 5885 O O      . HOH E 4 .   ? 30.754  -30.293 27.437  1    29.192 ? 1754 HOH A O      1 ? 
HETATM 5886 H H1     . HOH E 4 .   ? 30.501  -30.485 26.53   1    29.39  ? 1754 HOH A H1     1 ? 
HETATM 5887 H H2     . HOH E 4 .   ? 30.408  -29.404 27.598  1    31.055 ? 1754 HOH A H2     1 ? 
HETATM 5888 O O      . HOH E 4 .   ? 17.646  -34.501 11.501  1    30.001 ? 1755 HOH A O      1 ? 
HETATM 5889 H H1     . HOH E 4 .   ? 17.179  -35.101 12.13   1    29.81  ? 1755 HOH A H1     1 ? 
HETATM 5890 H H2     . HOH E 4 .   ? 17.027  -33.819 11.2    1    27.701 ? 1755 HOH A H2     1 ? 
HETATM 5891 O O      . HOH E 4 .   ? 36.74   -25.071 11.916  1    30.909 ? 1756 HOH A O      1 ? 
HETATM 5892 H H1     . HOH E 4 .   ? 36.014  -25.694 12.122  1    29.647 ? 1756 HOH A H1     1 ? 
HETATM 5893 H H2     . HOH E 4 .   ? 37.578  -25.495 12.165  1    30.135 ? 1756 HOH A H2     1 ? 
HETATM 5894 O O      . HOH E 4 .   ? 17.271  -36.398 32.143  1    16.294 ? 1757 HOH A O      1 ? 
HETATM 5895 H H1     . HOH E 4 .   ? 16.404  -36.745 32.429  1    16.906 ? 1757 HOH A H1     1 ? 
HETATM 5896 H H2     . HOH E 4 .   ? 17.426  -35.605 32.697  1    16.228 ? 1757 HOH A H2     1 ? 
HETATM 5897 O O      . HOH E 4 .   ? 11.199  -4.818  22.702  1    37.143 ? 1758 HOH A O      1 ? 
HETATM 5898 H H1     . HOH E 4 .   ? 12.036  -4.744  23.201  1    35.554 ? 1758 HOH A H1     1 ? 
HETATM 5899 H H2     . HOH E 4 .   ? 11.139  -5.735  22.364  1    36.907 ? 1758 HOH A H2     1 ? 
HETATM 5900 O O      . HOH E 4 .   ? 6.36    -11.521 5.507   1    48.734 ? 1759 HOH A O      1 ? 
HETATM 5901 H H1     . HOH E 4 .   ? 6.319   -11.923 4.62    1    46.696 ? 1759 HOH A H1     1 ? 
HETATM 5902 H H2     . HOH E 4 .   ? 5.534   -11.746 5.967   1    51.851 ? 1759 HOH A H2     1 ? 
HETATM 5903 O O      . HOH E 4 .   ? 39.716  -17.023 8.189   1    32.76  ? 1760 HOH A O      1 ? 
HETATM 5904 H H1     . HOH E 4 .   ? 40.547  -17.094 8.692   1    31.687 ? 1760 HOH A H1     1 ? 
HETATM 5905 H H2     . HOH E 4 .   ? 39.527  -17.911 7.828   1    33.904 ? 1760 HOH A H2     1 ? 
HETATM 5906 O O      . HOH E 4 .   ? 26.85   -27.467 22.716  1    14.578 ? 1761 HOH A O      1 ? 
HETATM 5907 H H1     . HOH E 4 .   ? 26.679  -26.555 22.823  1    15.569 ? 1761 HOH A H1     1 ? 
HETATM 5908 H H2     . HOH E 4 .   ? 27.009  -27.487 21.767  1    16.567 ? 1761 HOH A H2     1 ? 
HETATM 5909 O O      . HOH E 4 .   ? 13.058  -34.189 14.547  1    35.251 ? 1762 HOH A O      1 ? 
HETATM 5910 H H1     . HOH E 4 .   ? 12.831  -34.055 13.604  1    36.104 ? 1762 HOH A H1     1 ? 
HETATM 5911 H H2     . HOH E 4 .   ? 13.546  -33.399 14.851  1    34.745 ? 1762 HOH A H2     1 ? 
HETATM 5912 O O      . HOH E 4 .   ? 37.136  -8.745  5.679   1    37.66  ? 1763 HOH A O      1 ? 
HETATM 5913 H H1     . HOH E 4 .   ? 37.267  -9.674  5.405   1    37.053 ? 1763 HOH A H1     1 ? 
HETATM 5914 H H2     . HOH E 4 .   ? 37.134  -8.716  6.657   1    34.632 ? 1763 HOH A H2     1 ? 
HETATM 5915 O O      . HOH E 4 .   ? 27.946  -23.683 -2.063  1    33.846 ? 1764 HOH A O      1 ? 
HETATM 5916 H H1     . HOH E 4 .   ? 27.064  -24.001 -2.368  1    34.692 ? 1764 HOH A H1     1 ? 
HETATM 5917 H H2     . HOH E 4 .   ? 28.16   -22.872 -2.571  1    31.597 ? 1764 HOH A H2     1 ? 
HETATM 5918 O O      . HOH E 4 .   ? 20.673  -0.408  6.087   1    30.28  ? 1765 HOH A O      1 ? 
HETATM 5919 H H1     . HOH E 4 .   ? 20.228  -0.74   5.263   1    28.401 ? 1765 HOH A H1     1 ? 
HETATM 5920 H H2     . HOH E 4 .   ? 20.021  -0.345  6.831   1    28.229 ? 1765 HOH A H2     1 ? 
HETATM 5921 O O      . HOH E 4 .   ? 0.93    -32.124 17.697  1    33.172 ? 1766 HOH A O      1 ? 
HETATM 5922 H H1     . HOH E 4 .   ? 1.875   -31.927 17.534  1    30.221 ? 1766 HOH A H1     1 ? 
HETATM 5923 H H2     . HOH E 4 .   ? 0.423   -31.286 17.809  1    33.118 ? 1766 HOH A H2     1 ? 
HETATM 5924 O O      . HOH E 4 .   ? 30.931  -26.251 11.044  1    43.162 ? 1767 HOH A O      1 ? 
HETATM 5925 H H1     . HOH E 4 .   ? 30.218  -26.311 10.376  1    40.905 ? 1767 HOH A H1     1 ? 
HETATM 5926 H H2     . HOH E 4 .   ? 30.668  -25.604 11.735  1    42.768 ? 1767 HOH A H2     1 ? 
HETATM 5927 O O      . HOH E 4 .   ? 27.049  -5.831  -2.92   1    38.001 ? 1768 HOH A O      1 ? 
HETATM 5928 H H1     . HOH E 4 .   ? 27.854  -5.985  -2.374  1    35.312 ? 1768 HOH A H1     1 ? 
HETATM 5929 H H2     . HOH E 4 .   ? 26.743  -4.901  -2.785  1    38.239 ? 1768 HOH A H2     1 ? 
HETATM 5930 O O      . HOH E 4 .   ? 15.803  -0.731  8.023   1    21.629 ? 1769 HOH A O      1 ? 
HETATM 5931 H H1     . HOH E 4 .   ? 16.651  -0.671  8.511   1    22.853 ? 1769 HOH A H1     1 ? 
HETATM 5932 H H2     . HOH E 4 .   ? 16.055  -0.889  7.104   1    21.266 ? 1769 HOH A H2     1 ? 
HETATM 5933 O O      . HOH E 4 .   ? 22.827  -40.449 23.125  1    47.681 ? 1770 HOH A O      1 ? 
HETATM 5934 H H1     . HOH E 4 .   ? 21.976  -40.018 23.353  1    43.325 ? 1770 HOH A H1     1 ? 
HETATM 5935 H H2     . HOH E 4 .   ? 22.737  -40.844 22.234  1    45.722 ? 1770 HOH A H2     1 ? 
HETATM 5936 O O      . HOH E 4 .   ? -5.899  -16.838 25.608  1    40.444 ? 1771 HOH A O      1 ? 
HETATM 5937 H H1     . HOH E 4 .   ? -5.503  -16.905 26.493  1    38.998 ? 1771 HOH A H1     1 ? 
HETATM 5938 H H2     . HOH E 4 .   ? -6.095  -15.891 25.439  1    40.243 ? 1771 HOH A H2     1 ? 
HETATM 5939 O O      . HOH E 4 .   ? 17.747  -31.953 7.513   1    30.159 ? 1772 HOH A O      1 ? 
HETATM 5940 H H1     . HOH E 4 .   ? 18.263  -32.609 8.018   1    30.718 ? 1772 HOH A H1     1 ? 
HETATM 5941 H H2     . HOH E 4 .   ? 16.854  -31.962 7.907   1    30.614 ? 1772 HOH A H2     1 ? 
HETATM 5942 O O      . HOH E 4 .   ? 24.883  -8.641  -12.768 1    27.658 ? 1773 HOH A O      1 ? 
HETATM 5943 H H1     . HOH E 4 .   ? 25.731  -8.983  -13.124 1    28.585 ? 1773 HOH A H1     1 ? 
HETATM 5944 H H2     . HOH E 4 .   ? 24.571  -7.925  -13.357 1    28.424 ? 1773 HOH A H2     1 ? 
HETATM 5945 O O      . HOH E 4 .   ? 24.526  -38.003 17.116  1    25.674 ? 1774 HOH A O      1 ? 
HETATM 5946 H H1     . HOH E 4 .   ? 24.13   -38.306 16.264  1    23.168 ? 1774 HOH A H1     1 ? 
HETATM 5947 H H2     . HOH E 4 .   ? 25.472  -37.799 16.956  1    24.413 ? 1774 HOH A H2     1 ? 
HETATM 5948 O O      . HOH E 4 .   ? 14.562  -5.513  20.028  1    22.645 ? 1775 HOH A O      1 ? 
HETATM 5949 H H1     . HOH E 4 .   ? 13.94   -5.068  19.431  1    24.281 ? 1775 HOH A H1     1 ? 
HETATM 5950 H H2     . HOH E 4 .   ? 14.212  -6.399  20.156  1    22.983 ? 1775 HOH A H2     1 ? 
HETATM 5951 O O      . HOH E 4 .   ? 25.502  -3.038  -8.010  1    47.623 ? 1776 HOH A O      1 ? 
HETATM 5952 H H1     . HOH E 4 .   ? 24.612  -2.660  -7.899  1    44.174 ? 1776 HOH A H1     1 ? 
HETATM 5953 H H2     . HOH E 4 .   ? 25.833  -3.311  -7.126  1    48.68  ? 1776 HOH A H2     1 ? 
HETATM 5954 O O      . HOH E 4 .   ? 39.001  -19.601 10.165  1    19.624 ? 1777 HOH A O      1 ? 
HETATM 5955 H H1     . HOH E 4 .   ? 39.686  -19.898 9.544   1    20.257 ? 1777 HOH A H1     1 ? 
HETATM 5956 H H2     . HOH E 4 .   ? 38.873  -18.66  10.001  1    20.724 ? 1777 HOH A H2     1 ? 
HETATM 5957 O O      . HOH E 4 .   ? -0.539  -16.001 17.701  1    47.732 ? 1778 HOH A O      1 ? 
HETATM 5958 H H1     . HOH E 4 .   ? 0.297   -16.244 18.148  1    49.567 ? 1778 HOH A H1     1 ? 
HETATM 5959 H H2     . HOH E 4 .   ? -1.2    -15.767 18.384  1    44.114 ? 1778 HOH A H2     1 ? 
HETATM 5960 O O      . HOH E 4 .   ? 2.267   -19.383 7.836   1    28.24  ? 1779 HOH A O      1 ? 
HETATM 5961 H H1     . HOH E 4 .   ? 1.878   -19.133 6.975   1    28.251 ? 1779 HOH A H1     1 ? 
HETATM 5962 H H2     . HOH E 4 .   ? 2.568   -20.318 7.781   1    27.784 ? 1779 HOH A H2     1 ? 
HETATM 5963 O O      . HOH E 4 .   ? 15.231  -5.867  -11.109 1    32.217 ? 1780 HOH A O      1 ? 
HETATM 5964 H H1     . HOH E 4 .   ? 15.509  -6.652  -11.627 1    29.154 ? 1780 HOH A H1     1 ? 
HETATM 5965 H H2     . HOH E 4 .   ? 15.63   -5.062  -11.501 1    30.702 ? 1780 HOH A H2     1 ? 
HETATM 5966 O O      . HOH E 4 .   ? 21.271  -6.47   22.655  1    37.17  ? 1781 HOH A O      1 ? 
HETATM 5967 H H1     . HOH E 4 .   ? 21.781  -7.142  23.133  1    33.515 ? 1781 HOH A H1     1 ? 
HETATM 5968 H H2     . HOH E 4 .   ? 20.913  -5.857  23.316  1    37.43  ? 1781 HOH A H2     1 ? 
HETATM 5969 O O      . HOH E 4 .   ? -6.982  -14.403 29.631  1    41.906 ? 1782 HOH A O      1 ? 
HETATM 5970 H H1     . HOH E 4 .   ? -7.852  -13.960 29.645  1    39.548 ? 1782 HOH A H1     1 ? 
HETATM 5971 H H2     . HOH E 4 .   ? -6.307  -13.715 29.493  1    40.787 ? 1782 HOH A H2     1 ? 
HETATM 5972 O O      . HOH E 4 .   ? -6.377  -16.574 16.409  1    38.195 ? 1783 HOH A O      1 ? 
HETATM 5973 H H1     . HOH E 4 .   ? -7.077  -17.236 16.197  1    34.913 ? 1783 HOH A H1     1 ? 
HETATM 5974 H H2     . HOH E 4 .   ? -6.619  -15.692 16.037  1    36.78  ? 1783 HOH A H2     1 ? 
HETATM 5975 O O      . HOH E 4 .   ? 6.23    -22.187 1.77    1    42.816 ? 1784 HOH A O      1 ? 
HETATM 5976 H H1     . HOH E 4 .   ? 7.182   -22.288 2.008   1    43.138 ? 1784 HOH A H1     1 ? 
HETATM 5977 H H2     . HOH E 4 .   ? 5.835   -21.454 2.288   1    36.936 ? 1784 HOH A H2     1 ? 
HETATM 5978 O O      . HOH E 4 .   ? 23.112  -19.018 32.376  1    30.6   ? 1785 HOH A O      1 ? 
HETATM 5979 H H1     . HOH E 4 .   ? 23.291  -18.478 31.577  1    31.73  ? 1785 HOH A H1     1 ? 
HETATM 5980 H H2     . HOH E 4 .   ? 22.337  -18.641 32.834  1    30.164 ? 1785 HOH A H2     1 ? 
HETATM 5981 O O      . HOH E 4 .   ? 20.336  -39.659 14.343  1    38.215 ? 1786 HOH A O      1 ? 
HETATM 5982 H H1     . HOH E 4 .   ? 19.569  -39.818 13.756  1    36.888 ? 1786 HOH A H1     1 ? 
HETATM 5983 H H2     . HOH E 4 .   ? 20.531  -40.488 14.829  1    39.4   ? 1786 HOH A H2     1 ? 
HETATM 5984 O O      . HOH E 4 .   ? 17.842  -5.266  -11.15  1    28.428 ? 1787 HOH A O      1 ? 
HETATM 5985 H H1     . HOH E 4 .   ? 18.61   -5.13   -10.575 1    32.471 ? 1787 HOH A H1     1 ? 
HETATM 5986 H H2     . HOH E 4 .   ? 17.231  -5.811  -10.643 1    29.727 ? 1787 HOH A H2     1 ? 
HETATM 5987 O O      . HOH E 4 .   ? 20.92   0.051   8.494   1    39.013 ? 1788 HOH A O      1 ? 
HETATM 5988 H H1     . HOH E 4 .   ? 21.287  0.711   9.11    1    39.534 ? 1788 HOH A H1     1 ? 
HETATM 5989 H H2     . HOH E 4 .   ? 21.554  -0.042  7.755   1    36.879 ? 1788 HOH A H2     1 ? 
HETATM 5990 O O      . HOH E 4 .   ? 30.305  -15.305 -2.315  1    19.73  ? 1789 HOH A O      1 ? 
HETATM 5991 H H1     . HOH E 4 .   ? 31.276  -15.208 -2.282  1    19.542 ? 1789 HOH A H1     1 ? 
HETATM 5992 H H2     . HOH E 4 .   ? 30.067  -16.046 -1.704  1    20.047 ? 1789 HOH A H2     1 ? 
HETATM 5993 O O      . HOH E 4 .   ? -16.003 -24.897 19.58   1    47.672 ? 1790 HOH A O      1 ? 
HETATM 5994 H H1     . HOH E 4 .   ? -15.378 -25.141 18.852  1    40.12  ? 1790 HOH A H1     1 ? 
HETATM 5995 H H2     . HOH E 4 .   ? -15.615 -25.075 20.475  1    44.633 ? 1790 HOH A H2     1 ? 
HETATM 5996 O O      . HOH E 4 .   ? 39.341  -13.769 28.991  1    32.521 ? 1791 HOH A O      1 ? 
HETATM 5997 H H1     . HOH E 4 .   ? 38.975  -14.667 28.869  1    28.529 ? 1791 HOH A H1     1 ? 
HETATM 5998 H H2     . HOH E 4 .   ? 40.157  -13.693 28.449  1    30.428 ? 1791 HOH A H2     1 ? 
HETATM 5999 O O      . HOH E 4 .   ? -11.523 -13.174 26.146  1    35.449 ? 1792 HOH A O      1 ? 
HETATM 6000 H H1     . HOH E 4 .   ? -10.781 -13.312 26.773  1    36.468 ? 1792 HOH A H1     1 ? 
HETATM 6001 H H2     . HOH E 4 .   ? -12.144 -13.92  26.253  1    34.48  ? 1792 HOH A H2     1 ? 
HETATM 6002 O O      . HOH E 4 .   ? 8.587   -15.077 32.625  1    34.503 ? 1793 HOH A O      1 ? 
HETATM 6003 H H1     . HOH E 4 .   ? 8.47    -14.302 33.218  1    31.239 ? 1793 HOH A H1     1 ? 
HETATM 6004 H H2     . HOH E 4 .   ? 7.848   -15.709 32.773  1    32.707 ? 1793 HOH A H2     1 ? 
HETATM 6005 O O      . HOH E 4 .   ? 27.449  -19.18  -7.796  1    39.976 ? 1794 HOH A O      1 ? 
HETATM 6006 H H1     . HOH E 4 .   ? 28.291  -19.659 -7.661  1    34.434 ? 1794 HOH A H1     1 ? 
HETATM 6007 H H2     . HOH E 4 .   ? 27.349  -18.975 -8.751  1    37.227 ? 1794 HOH A H2     1 ? 
HETATM 6008 O O      . HOH E 4 .   ? -16.481 -22.45  18.281  1    44.808 ? 1795 HOH A O      1 ? 
HETATM 6009 H H1     . HOH E 4 .   ? -15.891 -21.727 18.575  1    39.224 ? 1795 HOH A H1     1 ? 
HETATM 6010 H H2     . HOH E 4 .   ? -17.286 -22.452 18.844  1    43.465 ? 1795 HOH A H2     1 ? 
HETATM 6011 O O      . HOH E 4 .   ? 25.290  -0.660  3.590   1    38.674 ? 1796 HOH A O      1 ? 
HETATM 6012 H H1     . HOH E 4 .   ? 26.127  -1.063  3.290   1    35.799 ? 1796 HOH A H1     1 ? 
HETATM 6013 H H2     . HOH E 4 .   ? 25.343  0.298   3.418   1    35.866 ? 1796 HOH A H2     1 ? 
HETATM 6014 O O      . HOH E 4 .   ? 6.47    -9.653  14.201  1    24.78  ? 1797 HOH A O      1 ? 
HETATM 6015 H H1     . HOH E 4 .   ? 5.911   -10.066 13.537  1    24.96  ? 1797 HOH A H1     1 ? 
HETATM 6016 H H2     . HOH E 4 .   ? 6.06    -8.806  14.423  1    25.98  ? 1797 HOH A H2     1 ? 
HETATM 6017 O O      . HOH E 4 .   ? 19.831  -0.75   12.243  1    26.098 ? 1798 HOH A O      1 ? 
HETATM 6018 H H1     . HOH E 4 .   ? 20.336  -1.12   13      1    23.742 ? 1798 HOH A H1     1 ? 
HETATM 6019 H H2     . HOH E 4 .   ? 19.1    -0.203  12.59   1    25.22  ? 1798 HOH A H2     1 ? 
HETATM 6020 O O      . HOH E 4 .   ? 4.52    -16.148 33.107  1    43.182 ? 1799 HOH A O      1 ? 
HETATM 6021 H H1     . HOH E 4 .   ? 3.852   -16.008 32.405  1    45.441 ? 1799 HOH A H1     1 ? 
HETATM 6022 H H2     . HOH E 4 .   ? 4.636   -15.3   33.587  1    41.89  ? 1799 HOH A H2     1 ? 
HETATM 6023 O O      . HOH E 4 .   ? -0.214  -13.041 22.643  1    38.508 ? 1800 HOH A O      1 ? 
HETATM 6024 H H1     . HOH E 4 .   ? 0.272   -13.764 22.193  1    37.879 ? 1800 HOH A H1     1 ? 
HETATM 6025 H H2     . HOH E 4 .   ? 0.201   -12.863 23.516  1    40.701 ? 1800 HOH A H2     1 ? 
HETATM 6026 O O      . HOH E 4 .   ? 13.57   -1.901  -7.364  1    70.393 ? 1801 HOH A O      1 ? 
HETATM 6027 H H1     . HOH E 4 .   ? 14.076  -2.617  -6.938  1    70.577 ? 1801 HOH A H1     1 ? 
HETATM 6028 H H2     . HOH E 4 .   ? 12.648  -1.956  -7.048  1    69.435 ? 1801 HOH A H2     1 ? 
HETATM 6029 O O      . HOH E 4 .   ? 26.902  -37.381 15.701  1    43.956 ? 1802 HOH A O      1 ? 
HETATM 6030 H H1     . HOH E 4 .   ? 27.253  -38.118 16.229  1    42.952 ? 1802 HOH A H1     1 ? 
HETATM 6031 H H2     . HOH E 4 .   ? 26.976  -36.578 16.246  1    42.996 ? 1802 HOH A H2     1 ? 
HETATM 6032 O O      . HOH E 4 .   ? -3.946  -37.907 32.058  1    42.624 ? 1803 HOH A O      1 ? 
HETATM 6033 H H1     . HOH E 4 .   ? -3.740  -37.461 32.902  1    41.783 ? 1803 HOH A H1     1 ? 
HETATM 6034 H H2     . HOH E 4 .   ? -4.707  -38.494 32.215  1    41.115 ? 1803 HOH A H2     1 ? 
HETATM 6035 O O      . HOH E 4 .   ? 8.225   -13.432 30.686  1    36.083 ? 1804 HOH A O      1 ? 
HETATM 6036 H H1     . HOH E 4 .   ? 8.471   -12.498 30.825  1    36.108 ? 1804 HOH A H1     1 ? 
HETATM 6037 H H2     . HOH E 4 .   ? 7.403   -13.443 30.154  1    33.387 ? 1804 HOH A H2     1 ? 
HETATM 6038 O O      . HOH E 4 .   ? -1.482  -18.683 15.697  1    39.915 ? 1805 HOH A O      1 ? 
HETATM 6039 H H1     . HOH E 4 .   ? -1.93   -19.206 16.387  1    37.515 ? 1805 HOH A H1     1 ? 
HETATM 6040 H H2     . HOH E 4 .   ? -1.426  -17.759 16.015  1    37.966 ? 1805 HOH A H2     1 ? 
HETATM 6041 O O      . HOH E 4 .   ? 29.897  -11.025 -6.288  1    34.927 ? 1806 HOH A O      1 ? 
HETATM 6042 H H1     . HOH E 4 .   ? 30.248  -11.078 -5.376  1    33.32  ? 1806 HOH A H1     1 ? 
HETATM 6043 H H2     . HOH E 4 .   ? 29.384  -10.2   -6.348  1    32.683 ? 1806 HOH A H2     1 ? 
HETATM 6044 O O      . HOH E 4 .   ? 19.266  -29.325 -7.332  1    33.149 ? 1807 HOH A O      1 ? 
HETATM 6045 H H1     . HOH E 4 .   ? 19.3    -29.206 -8.293  1    30.256 ? 1807 HOH A H1     1 ? 
HETATM 6046 H H2     . HOH E 4 .   ? 18.326  -29.328 -7.073  1    30.576 ? 1807 HOH A H2     1 ? 
HETATM 6047 O O      . HOH E 4 .   ? 6.238   -6.702  -6.817  1    43.188 ? 1808 HOH A O      1 ? 
HETATM 6048 H H1     . HOH E 4 .   ? 5.965   -7.016  -5.928  1    41.175 ? 1808 HOH A H1     1 ? 
HETATM 6049 H H2     . HOH E 4 .   ? 7.095   -6.212  -6.74   1    38.441 ? 1808 HOH A H2     1 ? 
HETATM 6050 O O      . HOH E 4 .   ? 29.568  -12.62  -9.774  1    45.128 ? 1809 HOH A O      1 ? 
HETATM 6051 H H1     . HOH E 4 .   ? 29.226  -12.835 -10.664 1    43.148 ? 1809 HOH A H1     1 ? 
HETATM 6052 H H2     . HOH E 4 .   ? 30.471  -12.988 -9.704  1    44.638 ? 1809 HOH A H2     1 ? 
HETATM 6053 O O      . HOH E 4 .   ? 39.213  -11.424 5.043   1    47.839 ? 1810 HOH A O      1 ? 
HETATM 6054 H H1     . HOH E 4 .   ? 39.234  -10.854 5.838   1    45.569 ? 1810 HOH A H1     1 ? 
HETATM 6055 H H2     . HOH E 4 .   ? 38.362  -11.264 4.585   1    48.637 ? 1810 HOH A H2     1 ? 
HETATM 6056 O O      . HOH E 4 .   ? -3.142  -32.732 19.873  1    54.521 ? 1811 HOH A O      1 ? 
HETATM 6057 H H1     . HOH E 4 .   ? -3.231  -33.561 19.355  1    56.648 ? 1811 HOH A H1     1 ? 
HETATM 6058 H H2     . HOH E 4 .   ? -4.015  -32.291 19.904  1    54.967 ? 1811 HOH A H2     1 ? 
HETATM 6059 O O      . HOH E 4 .   ? 17.161  0.247   10.059  1    34.439 ? 1812 HOH A O      1 ? 
HETATM 6060 H H1     . HOH E 4 .   ? 18.083  0.485   9.86    1    31.847 ? 1812 HOH A H1     1 ? 
HETATM 6061 H H2     . HOH E 4 .   ? 17.101  0.096   11.016  1    32.5   ? 1812 HOH A H2     1 ? 
HETATM 6062 O O      . HOH E 4 .   ? 12.31   -1.523  -4.503  1    28.76  ? 1813 HOH A O      1 ? 
HETATM 6063 H H1     . HOH E 4 .   ? 12.602  -0.734  -5.004  1    27.963 ? 1813 HOH A H1     1 ? 
HETATM 6064 H H2     . HOH E 4 .   ? 11.331  -1.555  -4.447  1    27.218 ? 1813 HOH A H2     1 ? 
HETATM 6065 O O      . HOH E 4 .   ? 22.779  0.093   2.849   1    30.731 ? 1814 HOH A O      1 ? 
HETATM 6066 H H1     . HOH E 4 .   ? 22.041  -0.531  2.673   1    33.469 ? 1814 HOH A H1     1 ? 
HETATM 6067 H H2     . HOH E 4 .   ? 23.619  -0.372  2.649   1    30.765 ? 1814 HOH A H2     1 ? 
HETATM 6068 O O      . HOH E 4 .   ? 6.178   -20.327 -2.157  1    25.46  ? 1815 HOH A O      1 ? 
HETATM 6069 H H1     . HOH E 4 .   ? 6.955   -20.598 -1.621  1    26.821 ? 1815 HOH A H1     1 ? 
HETATM 6070 H H2     . HOH E 4 .   ? 5.756   -19.594 -1.672  1    27.056 ? 1815 HOH A H2     1 ? 
HETATM 6071 O O      . HOH E 4 .   ? 18.378  -40.956 26.922  1    42.401 ? 1816 HOH A O      1 ? 
HETATM 6072 H H1     . HOH E 4 .   ? 18.352  -41.14  27.882  1    38.359 ? 1816 HOH A H1     1 ? 
HETATM 6073 H H2     . HOH E 4 .   ? 19.308  -40.98  26.612  1    40.165 ? 1816 HOH A H2     1 ? 
HETATM 6074 O O      . HOH E 4 .   ? 28.415  -27.701 8.174   1    24.108 ? 1817 HOH A O      1 ? 
HETATM 6075 H H1     . HOH E 4 .   ? 28.013  -27.132 8.866   1    23.783 ? 1817 HOH A H1     1 ? 
HETATM 6076 H H2     . HOH E 4 .   ? 27.718  -27.899 7.518   1    22.828 ? 1817 HOH A H2     1 ? 
HETATM 6077 O O      . HOH E 4 .   ? 22.049  -13.327 26.196  1    30.354 ? 1818 HOH A O      1 ? 
HETATM 6078 H H1     . HOH E 4 .   ? 22.533  -13.364 25.365  1    30.494 ? 1818 HOH A H1     1 ? 
HETATM 6079 H H2     . HOH E 4 .   ? 21.416  -12.59  26.129  1    30.246 ? 1818 HOH A H2     1 ? 
HETATM 6080 O O      . HOH E 4 .   ? 37.965  -21.539 8.585   1    25.024 ? 1819 HOH A O      1 ? 
HETATM 6081 H H1     . HOH E 4 .   ? 38.682  -21.478 7.93    1    24.573 ? 1819 HOH A H1     1 ? 
HETATM 6082 H H2     . HOH E 4 .   ? 38.198  -20.918 9.3     1    25.597 ? 1819 HOH A H2     1 ? 
HETATM 6083 O O      . HOH E 4 .   ? 32.770  -33.750 25.565  1    49.175 ? 1820 HOH A O      1 ? 
HETATM 6084 H H1     . HOH E 4 .   ? 32.976  -33.061 26.226  1    48.647 ? 1820 HOH A H1     1 ? 
HETATM 6085 H H2     . HOH E 4 .   ? 33.285  -33.562 24.752  1    51.134 ? 1820 HOH A H2     1 ? 
HETATM 6086 O O      . HOH E 4 .   ? 4.77    -21.865 -0.438  1    26.493 ? 1821 HOH A O      1 ? 
HETATM 6087 H H1     . HOH E 4 .   ? 5.145   -21.77  0.457   1    26.189 ? 1821 HOH A H1     1 ? 
HETATM 6088 H H2     . HOH E 4 .   ? 5.258   -21.268 -1.03   1    25.873 ? 1821 HOH A H2     1 ? 
HETATM 6089 O O      . HOH E 4 .   ? 13.746  -13.906 -19.662 1    37.623 ? 1822 HOH A O      1 ? 
HETATM 6090 H H1     . HOH E 4 .   ? 14.157  -13.605 -20.49  1    36.246 ? 1822 HOH A H1     1 ? 
HETATM 6091 H H2     . HOH E 4 .   ? 12.859  -13.498 -19.602 1    38.543 ? 1822 HOH A H2     1 ? 
HETATM 6092 O O      . HOH E 4 .   ? 25.707  -35.117 21.865  1    29.782 ? 1823 HOH A O      1 ? 
HETATM 6093 H H1     . HOH E 4 .   ? 26.018  -35.456 22.743  1    29.48  ? 1823 HOH A H1     1 ? 
HETATM 6094 H H2     . HOH E 4 .   ? 26.436  -35.131 21.211  1    28.15  ? 1823 HOH A H2     1 ? 
HETATM 6095 O O      . HOH E 4 .   ? 18.883  -7.456  21.859  1    32.872 ? 1824 HOH A O      1 ? 
HETATM 6096 H H1     . HOH E 4 .   ? 18.461  -6.648  21.508  1    31.407 ? 1824 HOH A H1     1 ? 
HETATM 6097 H H2     . HOH E 4 .   ? 19.803  -7.232  22.046  1    31.475 ? 1824 HOH A H2     1 ? 
HETATM 6098 O O      . HOH E 4 .   ? 6.146   -16.819 -8.02   1    44.721 ? 1825 HOH A O      1 ? 
HETATM 6099 H H1     . HOH E 4 .   ? 5.41    -16.581 -7.428  1    41.348 ? 1825 HOH A H1     1 ? 
HETATM 6100 H H2     . HOH E 4 .   ? 5.787   -17.359 -8.748  1    46.256 ? 1825 HOH A H2     1 ? 
HETATM 6101 O O      . HOH E 4 .   ? 20.622  1.851   4.539   1    40.644 ? 1826 HOH A O      1 ? 
HETATM 6102 H H1     . HOH E 4 .   ? 21.514  1.462   4.458   1    36.074 ? 1826 HOH A H1     1 ? 
HETATM 6103 H H2     . HOH E 4 .   ? 20.385  2.245   3.676   1    41.639 ? 1826 HOH A H2     1 ? 
HETATM 6104 O O      . HOH E 4 .   ? 10.219  -17.23  -13.963 1    36.143 ? 1827 HOH A O      1 ? 
HETATM 6105 H H1     . HOH E 4 .   ? 9.739   -17.305 -13.118 1    35.719 ? 1827 HOH A H1     1 ? 
HETATM 6106 H H2     . HOH E 4 .   ? 10.393  -18.132 -14.297 1    34.899 ? 1827 HOH A H2     1 ? 
HETATM 6107 O O      . HOH E 4 .   ? 33.817  -34.315 20.208  1    49.711 ? 1828 HOH A O      1 ? 
HETATM 6108 H H1     . HOH E 4 .   ? 33.23   -34.938 19.731  1    50.134 ? 1828 HOH A H1     1 ? 
HETATM 6109 H H2     . HOH E 4 .   ? 33.463  -34.188 21.113  1    43.716 ? 1828 HOH A H2     1 ? 
HETATM 6110 O O      . HOH E 4 .   ? 10.824  -15.364 34.719  1    28.369 ? 1829 HOH A O      1 ? 
HETATM 6111 H H1     . HOH E 4 .   ? 11.708  -15.489 34.297  1    28.271 ? 1829 HOH A H1     1 ? 
HETATM 6112 H H2     . HOH E 4 .   ? 10.157  -15.365 34.014  1    28.281 ? 1829 HOH A H2     1 ? 
HETATM 6113 O O      . HOH E 4 .   ? 21.707  -29.965 -1.185  1    41.443 ? 1830 HOH A O      1 ? 
HETATM 6114 H H1     . HOH E 4 .   ? 21.013  -29.562 -1.739  1    39.364 ? 1830 HOH A H1     1 ? 
HETATM 6115 O O      . HOH E 4 .   ? 26.854  -22.508 35.213  1    22.601 ? 1831 HOH A O      1 ? 
HETATM 6116 H H1     . HOH E 4 .   ? 27.770  -22.572 34.910  1    23.103 ? 1831 HOH A H1     1 ? 
HETATM 6117 H H2     . HOH E 4 .   ? 26.375  -23.178 34.690  1    23.144 ? 1831 HOH A H2     1 ? 
HETATM 6118 O O      . HOH E 4 .   ? 1.412   -20.186 3.114   1    39.865 ? 1832 HOH A O      1 ? 
HETATM 6119 H H1     . HOH E 4 .   ? 1.826   -20.536 2.302   1    40.04  ? 1832 HOH A H1     1 ? 
HETATM 6120 H H2     . HOH E 4 .   ? 0.988   -19.337 2.895   1    38.51  ? 1832 HOH A H2     1 ? 
HETATM 6121 O O      . HOH E 4 .   ? 31.099  -20.173 -3.263  1    41.798 ? 1833 HOH A O      1 ? 
HETATM 6122 H H1     . HOH E 4 .   ? 31.169  -20.925 -2.646  1    39.816 ? 1833 HOH A H1     1 ? 
HETATM 6123 H H2     . HOH E 4 .   ? 31.659  -19.436 -2.933  1    39.285 ? 1833 HOH A H2     1 ? 
HETATM 6124 O O      . HOH E 4 .   ? 24.328  -26.673 4.394   1    31.621 ? 1834 HOH A O      1 ? 
HETATM 6125 H H1     . HOH E 4 .   ? 23.629  -25.995 4.428   1    30.713 ? 1834 HOH A H1     1 ? 
HETATM 6126 H H2     . HOH E 4 .   ? 23.976  -27.491 4.792   1    30.151 ? 1834 HOH A H2     1 ? 
HETATM 6127 O O      . HOH E 4 .   ? 3.736   -29.318 15.769  1    21.653 ? 1835 HOH A O      1 ? 
HETATM 6128 H H1     . HOH E 4 .   ? 4.698   -29.461 15.802  1    20.995 ? 1835 HOH A H1     1 ? 
HETATM 6129 H H2     . HOH E 4 .   ? 3.567   -28.37  15.967  1    21.52  ? 1835 HOH A H2     1 ? 
HETATM 6130 O O      . HOH E 4 .   ? 12.946  -3.478  19.714  1    44.889 ? 1836 HOH A O      1 ? 
HETATM 6131 H H1     . HOH E 4 .   ? 13.686  -3.13   20.241  1    44.18  ? 1836 HOH A H1     1 ? 
HETATM 6132 H H2     . HOH E 4 .   ? 12.418  -2.711  19.421  1    46.4   ? 1836 HOH A H2     1 ? 
HETATM 6133 O O      . HOH E 4 .   ? 2.991   -21.871 -3.338  1    47.485 ? 1837 HOH A O      1 ? 
HETATM 6134 H H1     . HOH E 4 .   ? 2.979   -21.595 -2.401  1    48.622 ? 1837 HOH A H1     1 ? 
HETATM 6135 H H2     . HOH E 4 .   ? 3.536   -21.240 -3.847  1    45.158 ? 1837 HOH A H2     1 ? 
HETATM 6136 O O      . HOH E 4 .   ? 0.656   -36.455 31.775  1    31.483 ? 1838 HOH A O      1 ? 
HETATM 6137 H H1     . HOH E 4 .   ? 0.401   -37.312 31.383  1    28.957 ? 1838 HOH A H1     1 ? 
HETATM 6138 H H2     . HOH E 4 .   ? 1.376   -36.632 32.411  1    30.744 ? 1838 HOH A H2     1 ? 
HETATM 6139 O O      . HOH E 4 .   ? 39.141  -19.123 24.847  1    38.423 ? 1839 HOH A O      1 ? 
HETATM 6140 H H1     . HOH E 4 .   ? 39.538  -18.555 25.532  1    36.354 ? 1839 HOH A H1     1 ? 
HETATM 6141 H H2     . HOH E 4 .   ? 38.759  -18.529 24.174  1    36.953 ? 1839 HOH A H2     1 ? 
HETATM 6142 O O      . HOH E 4 .   ? 23.424  -18.528 35      1    30.529 ? 1840 HOH A O      1 ? 
HETATM 6143 H H1     . HOH E 4 .   ? 24.258  -18.272 34.55   1    30.325 ? 1840 HOH A H1     1 ? 
HETATM 6144 H H2     . HOH E 4 .   ? 22.737  -17.861 34.796  1    30.851 ? 1840 HOH A H2     1 ? 
HETATM 6145 O O      . HOH E 4 .   ? -1.949  -3.093  19.086  1    41.968 ? 1841 HOH A O      1 ? 
HETATM 6146 H H1     . HOH E 4 .   ? -1.875  -3.739  19.822  1    38.21  ? 1841 HOH A H1     1 ? 
HETATM 6147 H H2     . HOH E 4 .   ? -1.341  -3.36   18.365  1    38.549 ? 1841 HOH A H2     1 ? 
HETATM 6148 O O      . HOH E 4 .   ? 18.802  -0.478  19.609  1    55.15  ? 1842 HOH A O      1 ? 
HETATM 6149 H H1     . HOH E 4 .   ? 19.665  -0.357  20.058  1    55.17  ? 1842 HOH A H1     1 ? 
HETATM 6150 H H2     . HOH E 4 .   ? 18.955  -0.55   18.645  1    50.486 ? 1842 HOH A H2     1 ? 
HETATM 6151 O O      . HOH E 4 .   ? -16.367 -21.655 21.227  1    38.518 ? 1843 HOH A O      1 ? 
HETATM 6152 H H1     . HOH E 4 .   ? -17.156 -21.983 20.770  1    38.236 ? 1843 HOH A H1     1 ? 
HETATM 6153 H H2     . HOH E 4 .   ? -16.486 -21.799 22.187  1    40.595 ? 1843 HOH A H2     1 ? 
HETATM 6154 O O      . HOH E 4 .   ? 22.202  -27.451 0.453   1    36.664 ? 1844 HOH A O      1 ? 
HETATM 6155 H H1     . HOH E 4 .   ? 22.068  -27.014 1.322   1    31.768 ? 1844 HOH A H1     1 ? 
HETATM 6156 H H2     . HOH E 4 .   ? 21.689  -28.296 0.387   1    33.25  ? 1844 HOH A H2     1 ? 
HETATM 6157 O O      . HOH E 4 .   ? 25.678  -7.093  20.841  1    32.069 ? 1845 HOH A O      1 ? 
HETATM 6158 H H1     . HOH E 4 .   ? 26.136  -6.93   19.974  1    32.818 ? 1845 HOH A H1     1 ? 
HETATM 6159 H H2     . HOH E 4 .   ? 25.786  -6.323  21.432  1    26.846 ? 1845 HOH A H2     1 ? 
HETATM 6160 O O      . HOH E 4 .   ? -18.116 -17.012 25.830  1    27.879 ? 1846 HOH A O      1 ? 
HETATM 6161 H H1     . HOH E 4 .   ? -18.781 -17.232 26.518  1    23.976 ? 1846 HOH A H1     1 ? 
HETATM 6162 H H2     . HOH E 4 .   ? -17.553 -16.256 26.119  1    26.716 ? 1846 HOH A H2     1 ? 
HETATM 6163 O O      . HOH E 4 .   ? 40.403  -26.959 21.557  1    39.887 ? 1847 HOH A O      1 ? 
HETATM 6164 H H1     . HOH E 4 .   ? 40.902  -27.486 20.921  1    35.687 ? 1847 HOH A H1     1 ? 
HETATM 6165 H H2     . HOH E 4 .   ? 40.066  -27.596 22.219  1    38.911 ? 1847 HOH A H2     1 ? 
HETATM 6166 O O      . HOH E 4 .   ? 3.306   -15.413 7.429   1    29.371 ? 1848 HOH A O      1 ? 
HETATM 6167 H H1     . HOH E 4 .   ? 3.461   -14.838 6.641   1    26.512 ? 1848 HOH A H1     1 ? 
HETATM 6168 H H2     . HOH E 4 .   ? 3.988   -15.206 8.092   1    28.965 ? 1848 HOH A H2     1 ? 
HETATM 6169 O O      . HOH E 4 .   ? 25.25   -8.749  24.314  1    41.608 ? 1849 HOH A O      1 ? 
HETATM 6170 H H1     . HOH E 4 .   ? 26.07   -8.98   24.794  1    39.893 ? 1849 HOH A H1     1 ? 
HETATM 6171 H H2     . HOH E 4 .   ? 24.478  -9.045  24.836  1    39.232 ? 1849 HOH A H2     1 ? 
HETATM 6172 O O      . HOH E 4 .   ? -4.199  -28.894 17.435  1    36.687 ? 1850 HOH A O      1 ? 
HETATM 6173 H H1     . HOH E 4 .   ? -4.391  -28.707 18.374  1    33.615 ? 1850 HOH A H1     1 ? 
HETATM 6174 H H2     . HOH E 4 .   ? -4.42   -28.094 16.912  1    34.29  ? 1850 HOH A H2     1 ? 
HETATM 6175 O O      . HOH E 4 .   ? 37.202  -6.45   10.934  1    38.559 ? 1851 HOH A O      1 ? 
HETATM 6176 H H1     . HOH E 4 .   ? 36.912  -7.374  10.768  1    35.696 ? 1851 HOH A H1     1 ? 
HETATM 6177 H H2     . HOH E 4 .   ? 36.984  -6.217  11.862  1    34.02  ? 1851 HOH A H2     1 ? 
HETATM 6178 O O      . HOH E 4 .   ? 22.688  1.320   0.421   1    30.385 ? 1852 HOH A O      1 ? 
HETATM 6179 H H1     . HOH E 4 .   ? 22.147  2.127   0.441   1    30.384 ? 1852 HOH A H1     1 ? 
HETATM 6180 H H2     . HOH E 4 .   ? 22.931  1.146   1.349   1    31.446 ? 1852 HOH A H2     1 ? 
HETATM 6181 O O      . HOH E 4 .   ? 0.466   -20.538 5.683   1    37.328 ? 1853 HOH A O      1 ? 
HETATM 6182 H H1     . HOH E 4 .   ? 0.483   -21.377 5.183   1    37.347 ? 1853 HOH A H1     1 ? 
HETATM 6183 H H2     . HOH E 4 .   ? 1.133   -19.951 5.294   1    35.308 ? 1853 HOH A H2     1 ? 
HETATM 6184 O O      . HOH E 4 .   ? 36.004  -35.377 18.915  1    64.744 ? 1854 HOH A O      1 ? 
HETATM 6185 H H1     . HOH E 4 .   ? 36.379  -34.902 19.682  1    65.872 ? 1854 HOH A H1     1 ? 
HETATM 6186 H H2     . HOH E 4 .   ? 35.03   -35.362 18.987  1    59.118 ? 1854 HOH A H2     1 ? 
HETATM 6187 O O      . HOH E 4 .   ? 26.698  -27.083 5.442   1    28.987 ? 1855 HOH A O      1 ? 
HETATM 6188 H H1     . HOH E 4 .   ? 25.993  -26.911 6.079   1    27.443 ? 1855 HOH A H1     1 ? 
HETATM 6189 H H2     . HOH E 4 .   ? 27.45   -27.402 5.965   1    26.82  ? 1855 HOH A H2     1 ? 
HETATM 6190 O O      . HOH E 4 .   ? 1.347   -14.442 -0.009  1    31.27  ? 1856 HOH A O      1 ? 
HETATM 6191 H H1     . HOH E 4 .   ? 2.216   -14.663 0.366   1    31.042 ? 1856 HOH A H1     1 ? 
HETATM 6192 H H2     . HOH E 4 .   ? 1.477   -13.609 -0.5    1    31.369 ? 1856 HOH A H2     1 ? 
HETATM 6193 O O      . HOH E 4 .   ? 24.096  -27.3   2.355   1    26.566 ? 1857 HOH A O      1 ? 
HETATM 6194 H H1     . HOH E 4 .   ? 24.037  -27.372 1.387   1    25.214 ? 1857 HOH A H1     1 ? 
HETATM 6195 H H2     . HOH E 4 .   ? 24.431  -26.4   2.579   1    25.368 ? 1857 HOH A H2     1 ? 
HETATM 6196 O O      . HOH E 4 .   ? 1.612   -17.79  16.077  1    42.506 ? 1858 HOH A O      1 ? 
HETATM 6197 H H1     . HOH E 4 .   ? 1.888   -18.65  16.443  1    40.954 ? 1858 HOH A H1     1 ? 
HETATM 6198 H H2     . HOH E 4 .   ? 0.706   -17.639 16.397  1    40.014 ? 1858 HOH A H2     1 ? 
HETATM 6199 O O      . HOH E 4 .   ? 24.592  -39.307 21.061  1    46.878 ? 1859 HOH A O      1 ? 
HETATM 6200 H H1     . HOH E 4 .   ? 23.766  -39.452 20.548  1    45.966 ? 1859 HOH A H1     1 ? 
HETATM 6201 H H2     . HOH E 4 .   ? 24.506  -39.762 21.92   1    43.485 ? 1859 HOH A H2     1 ? 
HETATM 6202 O O      . HOH E 4 .   ? 18.438  -38.352 31.084  1    30.291 ? 1860 HOH A O      1 ? 
HETATM 6203 H H1     . HOH E 4 .   ? 18.095  -37.445 31.213  1    29.634 ? 1860 HOH A H1     1 ? 
HETATM 6204 H H2     . HOH E 4 .   ? 17.855  -38.789 30.431  1    29.857 ? 1860 HOH A H2     1 ? 
HETATM 6205 O O      . HOH E 4 .   ? 15.48   -14.551 35.803  1    30.319 ? 1861 HOH A O      1 ? 
HETATM 6206 H H1     . HOH E 4 .   ? 16.277  -14.989 35.43   1    29.013 ? 1861 HOH A H1     1 ? 
HETATM 6207 H H2     . HOH E 4 .   ? 15.096  -13.956 35.134  1    26.666 ? 1861 HOH A H2     1 ? 
HETATM 6208 O O      . HOH E 4 .   ? 28.731  -8.189  -5.949  1    24.13  ? 1862 HOH A O      1 ? 
HETATM 6209 H H1     . HOH E 4 .   ? 29.344  -8.214  -5.194  1    23.601 ? 1862 HOH A H1     1 ? 
HETATM 6210 H H2     . HOH E 4 .   ? 29.29   -8.086  -6.732  1    23.042 ? 1862 HOH A H2     1 ? 
HETATM 6211 O O      . HOH E 4 .   ? 22.876  -20.954 33.944  1    28.856 ? 1863 HOH A O      1 ? 
HETATM 6212 H H1     . HOH E 4 .   ? 22.848  -21.912 33.731  1    26.756 ? 1863 HOH A H1     1 ? 
HETATM 6213 H H2     . HOH E 4 .   ? 23.079  -20.468 33.115  1    28.131 ? 1863 HOH A H2     1 ? 
HETATM 6214 O O      . HOH E 4 .   ? 31.812  -27.416 30.483  1    18.59  ? 1864 HOH A O      1 ? 
HETATM 6215 H H1     . HOH E 4 .   ? 32.031  -26.468 30.627  1    18.675 ? 1864 HOH A H1     1 ? 
HETATM 6216 H H2     . HOH E 4 .   ? 32.675  -27.872 30.427  1    18.967 ? 1864 HOH A H2     1 ? 
HETATM 6217 O O      . HOH E 4 .   ? 0.053   -27.484 14.071  1    34.971 ? 1865 HOH A O      1 ? 
HETATM 6218 H H1     . HOH E 4 .   ? 0.944   -27.81  13.837  1    32.318 ? 1865 HOH A H1     1 ? 
HETATM 6219 H H2     . HOH E 4 .   ? 0.112   -26.514 14.093  1    32.657 ? 1865 HOH A H2     1 ? 
HETATM 6220 O O      . HOH E 4 .   ? 14.775  -7.011  24.1    1    22.208 ? 1866 HOH A O      1 ? 
HETATM 6221 H H1     . HOH E 4 .   ? 14.091  -7.647  24.341  1    23.977 ? 1866 HOH A H1     1 ? 
HETATM 6222 H H2     . HOH E 4 .   ? 15.541  -7.545  23.839  1    23.67  ? 1866 HOH A H2     1 ? 
HETATM 6223 O O      . HOH E 4 .   ? 5.485   -35.565 16.187  1    45.074 ? 1867 HOH A O      1 ? 
HETATM 6224 H H1     . HOH E 4 .   ? 4.649   -36.034 15.995  1    40.826 ? 1867 HOH A H1     1 ? 
HETATM 6225 H H2     . HOH E 4 .   ? 5.852   -35.942 17.013  1    40.462 ? 1867 HOH A H2     1 ? 
HETATM 6226 O O      . HOH E 4 .   ? 30.354  -31.451 21.047  1    22.871 ? 1868 HOH A O      1 ? 
HETATM 6227 H H1     . HOH E 4 .   ? 30.555  -31.778 21.954  1    23.739 ? 1868 HOH A H1     1 ? 
HETATM 6228 H H2     . HOH E 4 .   ? 29.93   -32.187 20.558  1    21.943 ? 1868 HOH A H2     1 ? 
HETATM 6229 O O      . HOH E 4 .   ? 15.683  2.129   11.008  1    48.907 ? 1869 HOH A O      1 ? 
HETATM 6230 H H1     . HOH E 4 .   ? 15.427  1.325   11.503  1    46.007 ? 1869 HOH A H1     1 ? 
HETATM 6231 H H2     . HOH E 4 .   ? 16.653  2.104   10.888  1    45.091 ? 1869 HOH A H2     1 ? 
HETATM 6232 O O      . HOH E 4 .   ? 30.63   -11.303 -3.515  1    29.496 ? 1870 HOH A O      1 ? 
HETATM 6233 H H1     . HOH E 4 .   ? 31.174  -10.811 -2.871  1    28.56  ? 1870 HOH A H1     1 ? 
HETATM 6234 H H2     . HOH E 4 .   ? 31.114  -12.102 -3.783  1    28.483 ? 1870 HOH A H2     1 ? 
HETATM 6235 O O      . HOH E 4 .   ? 18.791  -34.672 8.92    1    32.323 ? 1871 HOH A O      1 ? 
HETATM 6236 H H1     . HOH E 4 .   ? 18.875  -35.61  9.209   1    33.636 ? 1871 HOH A H1     1 ? 
HETATM 6237 H H2     . HOH E 4 .   ? 18.352  -34.165 9.623   1    30.761 ? 1871 HOH A H2     1 ? 
HETATM 6238 O O      . HOH E 4 .   ? 37.05   -25.625 7.68    1    52.992 ? 1872 HOH A O      1 ? 
HETATM 6239 H H1     . HOH E 4 .   ? 36.18   -26.014 7.448   1    53.197 ? 1872 HOH A H1     1 ? 
HETATM 6240 H H2     . HOH E 4 .   ? 36.908  -24.695 7.935   1    52.416 ? 1872 HOH A H2     1 ? 
HETATM 6241 O O      . HOH E 4 .   ? 35.22   -18.504 29.673  1    31.528 ? 1873 HOH A O      1 ? 
HETATM 6242 H H1     . HOH E 4 .   ? 36.027  -18.786 29.201  1    30.417 ? 1873 HOH A H1     1 ? 
HETATM 6243 H H2     . HOH E 4 .   ? 35.472  -18.052 30.503  1    30.948 ? 1873 HOH A H2     1 ? 
HETATM 6244 O O      . HOH E 4 .   ? 2.667   -20.135 16.322  1    30.72  ? 1874 HOH A O      1 ? 
HETATM 6245 H H1     . HOH E 4 .   ? 2.602   -20.222 15.356  1    30.873 ? 1874 HOH A H1     1 ? 
HETATM 6246 H H2     . HOH E 4 .   ? 3.588   -20.363 16.568  1    31.717 ? 1874 HOH A H2     1 ? 
HETATM 6247 O O      . HOH E 4 .   ? 18.94   -28.347 -12.402 1    44.938 ? 1875 HOH A O      1 ? 
HETATM 6248 H H1     . HOH E 4 .   ? 19.108  -28.491 -11.45  1    44.033 ? 1875 HOH A H1     1 ? 
HETATM 6249 H H2     . HOH E 4 .   ? 19.501  -27.606 -12.699 1    45.774 ? 1875 HOH A H2     1 ? 
HETATM 6250 O O      . HOH E 4 .   ? 3.462   -30.024 8.156   1    56.007 ? 1876 HOH A O      1 ? 
HETATM 6251 H H1     . HOH E 4 .   ? 2.967   -29.961 7.312   1    52.729 ? 1876 HOH A H1     1 ? 
HETATM 6252 H H2     . HOH E 4 .   ? 4.329   -30.456 7.992   1    50.137 ? 1876 HOH A H2     1 ? 
HETATM 6253 O O      . HOH E 4 .   ? 1.979   -29.061 3.823   1    53.13  ? 1877 HOH A O      1 ? 
HETATM 6254 H H1     . HOH E 4 .   ? 1.683   -29.264 2.915   1    48.411 ? 1877 HOH A H1     1 ? 
HETATM 6255 H H2     . HOH E 4 .   ? 1.526   -29.673 4.442   1    49.742 ? 1877 HOH A H2     1 ? 
HETATM 6256 O O      . HOH E 4 .   ? 29.385  -8.276  19.307  1    29.32  ? 1878 HOH A O      1 ? 
HETATM 6257 H H1     . HOH E 4 .   ? 30.039  -8.384  20.026  1    28.286 ? 1878 HOH A H1     1 ? 
HETATM 6258 H H2     . HOH E 4 .   ? 28.554  -7.941  19.71   1    29.481 ? 1878 HOH A H2     1 ? 
HETATM 6259 O O      . HOH E 4 .   ? 8.777   -28.919 8.441   1    31.909 ? 1879 HOH A O      1 ? 
HETATM 6260 H H1     . HOH E 4 .   ? 8.122   -29.343 9.023   1    28.55  ? 1879 HOH A H1     1 ? 
HETATM 6261 H H2     . HOH E 4 .   ? 9.651   -28.994 8.880   1    32.046 ? 1879 HOH A H2     1 ? 
HETATM 6262 O O      . HOH E 4 .   ? 38.435  -9.828  8.476   1    32.637 ? 1880 HOH A O      1 ? 
HETATM 6263 H H1     . HOH E 4 .   ? 37.703  -9.537  7.893   1    31.974 ? 1880 HOH A H1     1 ? 
HETATM 6264 H H2     . HOH E 4 .   ? 38.122  -10.58  9.017   1    33.125 ? 1880 HOH A H2     1 ? 
HETATM 6265 O O      . HOH E 4 .   ? -4.053  -29.102 22.565  1    41.964 ? 1881 HOH A O      1 ? 
HETATM 6266 H H1     . HOH E 4 .   ? -4.516  -29.886 22.933  1    40.182 ? 1881 HOH A H1     1 ? 
HETATM 6267 H H2     . HOH E 4 .   ? -4.034  -29.17  21.587  1    36.62  ? 1881 HOH A H2     1 ? 
HETATM 6268 O O      . HOH E 4 .   ? 21.769  -16.823 30.478  1    39.948 ? 1882 HOH A O      1 ? 
HETATM 6269 H H1     . HOH E 4 .   ? 22.458  -17.333 29.995  1    40.329 ? 1882 HOH A H1     1 ? 
HETATM 6270 H H2     . HOH E 4 .   ? 21.333  -16.188 29.872  1    36.868 ? 1882 HOH A H2     1 ? 
HETATM 6271 O O      . HOH E 4 .   ? 35.200  -2.927  -0.099  1    34.223 ? 1883 HOH A O      1 ? 
HETATM 6272 H H1     . HOH E 4 .   ? 34.924  -3.770  -0.515  1    36.878 ? 1883 HOH A H1     1 ? 
HETATM 6273 H H2     . HOH E 4 .   ? 34.405  -2.429  0.145   1    32.481 ? 1883 HOH A H2     1 ? 
HETATM 6274 O O      . HOH E 4 .   ? 13.022  -23.389 42.042  1    33.2   ? 1884 HOH A O      1 ? 
HETATM 6275 H H1     . HOH E 4 .   ? 13.539  -24.208 42.178  1    31.98  ? 1884 HOH A H1     1 ? 
HETATM 6276 H H2     . HOH E 4 .   ? 13.612  -22.726 41.641  1    32.348 ? 1884 HOH A H2     1 ? 
HETATM 6277 O O      . HOH E 4 .   ? 1.162   -26.919 29.331  1    17.973 ? 1885 HOH A O      1 ? 
HETATM 6278 H H1     . HOH E 4 .   ? 0.808   -27.802 29.072  1    17.329 ? 1885 HOH A H1     1 ? 
HETATM 6279 H H2     . HOH E 4 .   ? 0.754   -26.234 28.758  1    17.608 ? 1885 HOH A H2     1 ? 
HETATM 6280 O O      . HOH E 4 .   ? 24.632  -31.174 5.746   1    32.488 ? 1886 HOH A O      1 ? 
HETATM 6281 H H1     . HOH E 4 .   ? 23.705  -31.218 6.029   1    30.647 ? 1886 HOH A H1     1 ? 
HETATM 6282 H H2     . HOH E 4 .   ? 24.931  -32.091 5.611   1    33.574 ? 1886 HOH A H2     1 ? 
HETATM 6283 O O      . HOH E 4 .   ? 2.498   -10.416 13.696  1    51.994 ? 1887 HOH A O      1 ? 
HETATM 6284 H H1     . HOH E 4 .   ? 2.835   -10.933 12.936  1    48.56  ? 1887 HOH A H1     1 ? 
HETATM 6285 H H2     . HOH E 4 .   ? 3.26    -10.183 14.261  1    50.871 ? 1887 HOH A H2     1 ? 
HETATM 6286 O O      . HOH E 4 .   ? 29.155  -34.866 25.208  1    29.861 ? 1888 HOH A O      1 ? 
HETATM 6287 H H1     . HOH E 4 .   ? 29.256  -35.018 24.246  1    29.387 ? 1888 HOH A H1     1 ? 
HETATM 6288 H H2     . HOH E 4 .   ? 28.217  -35.015 25.447  1    29.306 ? 1888 HOH A H2     1 ? 
HETATM 6289 O O      . HOH E 4 .   ? 39.505  -27.422 15.093  1    39.057 ? 1889 HOH A O      1 ? 
HETATM 6290 H H1     . HOH E 4 .   ? 39.463  -27.247 16.053  1    37.988 ? 1889 HOH A H1     1 ? 
HETATM 6291 H H2     . HOH E 4 .   ? 38.626  -27.742 14.82   1    37.468 ? 1889 HOH A H2     1 ? 
HETATM 6292 O O      . HOH E 4 .   ? 19.5    -15.118 34.108  1    37.712 ? 1890 HOH A O      1 ? 
HETATM 6293 H H1     . HOH E 4 .   ? 19.652  -15.507 33.227  1    34.937 ? 1890 HOH A H1     1 ? 
HETATM 6294 H H2     . HOH E 4 .   ? 18.764  -14.481 34.02   1    37.688 ? 1890 HOH A H2     1 ? 
HETATM 6295 O O      . HOH E 4 .   ? 27.764  -10.945 -13.650 1    42.944 ? 1891 HOH A O      1 ? 
HETATM 6296 H H1     . HOH E 4 .   ? 26.865  -10.688 -13.922 1    45.727 ? 1891 HOH A H1     1 ? 
HETATM 6297 H H2     . HOH E 4 .   ? 27.776  -11.910 -13.544 1    40.837 ? 1891 HOH A H2     1 ? 
HETATM 6298 O O      . HOH E 4 .   ? 5.157   -19.647 -4.524  1    26.07  ? 1892 HOH A O      1 ? 
HETATM 6299 H H1     . HOH E 4 .   ? 5.337   -19.989 -3.619  1    25.404 ? 1892 HOH A H1     1 ? 
HETATM 6300 H H2     . HOH E 4 .   ? 5.761   -20.121 -5.131  1    23.613 ? 1892 HOH A H2     1 ? 
HETATM 6301 O O      . HOH E 4 .   ? 11.491  -35.154 17.098  1    35.321 ? 1893 HOH A O      1 ? 
HETATM 6302 H H1     . HOH E 4 .   ? 11.537  -36.121 17.26   1    34.444 ? 1893 HOH A H1     1 ? 
HETATM 6303 H H2     . HOH E 4 .   ? 11.963  -34.945 16.27   1    33.732 ? 1893 HOH A H2     1 ? 
HETATM 6304 O O      . HOH E 4 .   ? 24.889  -8.491  -15.363 1    30.125 ? 1894 HOH A O      1 ? 
HETATM 6305 H H1     . HOH E 4 .   ? 25.190  -9.419  -15.336 1    29.115 ? 1894 HOH A H1     1 ? 
HETATM 6306 H H2     . HOH E 4 .   ? 24.415  -8.353  -16.203 1    28.997 ? 1894 HOH A H2     1 ? 
HETATM 6307 O O      . HOH E 4 .   ? 10.892  -14.915 37.167  1    33.883 ? 1895 HOH A O      1 ? 
HETATM 6308 H H1     . HOH E 4 .   ? 10.541  -14.723 36.266  1    31.488 ? 1895 HOH A H1     1 ? 
HETATM 6309 H H2     . HOH E 4 .   ? 10.198  -14.706 37.816  1    31.862 ? 1895 HOH A H2     1 ? 
HETATM 6310 O O      . HOH E 4 .   ? 24.974  -0.798  6.342   1    22.08  ? 1896 HOH A O      1 ? 
HETATM 6311 H H1     . HOH E 4 .   ? 24.984  -0.010  5.772   1    24.611 ? 1896 HOH A H1     1 ? 
HETATM 6312 H H2     . HOH E 4 .   ? 25.900  -1.098  6.370   1    21.512 ? 1896 HOH A H2     1 ? 
HETATM 6313 O O      . HOH E 4 .   ? 1.209   -16.904 8.073   1    38.303 ? 1897 HOH A O      1 ? 
HETATM 6314 H H1     . HOH E 4 .   ? 1.658   -17.427 7.383   1    35.021 ? 1897 HOH A H1     1 ? 
HETATM 6315 H H2     . HOH E 4 .   ? 1.525   -15.981 8.008   1    36.619 ? 1897 HOH A H2     1 ? 
HETATM 6316 O O      . HOH E 4 .   ? 29.68   -31.825 23.652  1    37.326 ? 1898 HOH A O      1 ? 
HETATM 6317 H H1     . HOH E 4 .   ? 30.464  -32.368 23.823  1    37.035 ? 1898 HOH A H1     1 ? 
HETATM 6318 H H2     . HOH E 4 .   ? 29.51   -31.286 24.455  1    35.314 ? 1898 HOH A H2     1 ? 
HETATM 6319 O O      . HOH E 4 .   ? 11.837  -16.448 39.51   1    34.851 ? 1899 HOH A O      1 ? 
HETATM 6320 H H1     . HOH E 4 .   ? 12.732  -16.229 39.841  1    34.929 ? 1899 HOH A H1     1 ? 
HETATM 6321 H H2     . HOH E 4 .   ? 11.66   -15.876 38.731  1    35.543 ? 1899 HOH A H2     1 ? 
HETATM 6322 O O      . HOH E 4 .   ? 27.667  -9.998  24.346  1    27.677 ? 1900 HOH A O      1 ? 
HETATM 6323 H H1     . HOH E 4 .   ? 27.941  -10.706 23.721  1    25.704 ? 1900 HOH A H1     1 ? 
HETATM 6324 H H2     . HOH E 4 .   ? 28.064  -10.203 25.217  1    27.548 ? 1900 HOH A H2     1 ? 
HETATM 6325 O O      . HOH E 4 .   ? 6.730   -17.069 39.732  1    32.467 ? 1901 HOH A O      1 ? 
HETATM 6326 H H1     . HOH E 4 .   ? 7.338   -17.829 39.631  1    29.876 ? 1901 HOH A H1     1 ? 
HETATM 6327 H H2     . HOH E 4 .   ? 5.886   -17.307 39.302  1    32.926 ? 1901 HOH A H2     1 ? 
HETATM 6328 O O      . HOH E 4 .   ? 28.631  -33.995 19.704  1    38.278 ? 1902 HOH A O      1 ? 
HETATM 6329 H H1     . HOH E 4 .   ? 28.382  -33.151 19.265  1    43.877 ? 1902 HOH A H1     1 ? 
HETATM 6330 H H2     . HOH E 4 .   ? 29.566  -34.151 19.485  1    39.449 ? 1902 HOH A H2     1 ? 
HETATM 6331 O O      . HOH E 4 .   ? 5.297   -36.507 29.125  1    45.773 ? 1903 HOH A O      1 ? 
HETATM 6332 H H1     . HOH E 4 .   ? 6.03    -36.756 28.525  1    47.518 ? 1903 HOH A H1     1 ? 
HETATM 6333 H H2     . HOH E 4 .   ? 4.87    -35.71  28.753  1    45.921 ? 1903 HOH A H2     1 ? 
HETATM 6334 O O      . HOH E 4 .   ? 1.313   -20.739 11.941  1    38.973 ? 1904 HOH A O      1 ? 
HETATM 6335 H H1     . HOH E 4 .   ? 0.887   -19.918 12.28   1    34.837 ? 1904 HOH A H1     1 ? 
HETATM 6336 H H2     . HOH E 4 .   ? 0.979   -20.916 11.042  1    33.84  ? 1904 HOH A H2     1 ? 
HETATM 6337 O O      . HOH E 4 .   ? 26.393  -10.999 27.626  1    66.051 ? 1905 HOH A O      1 ? 
HETATM 6338 H H1     . HOH E 4 .   ? 27.17   -10.538 27.24   1    65.823 ? 1905 HOH A H1     1 ? 
HETATM 6339 H H2     . HOH E 4 .   ? 25.769  -11.232 26.907  1    59.528 ? 1905 HOH A H2     1 ? 
HETATM 6340 O O      . HOH E 4 .   ? 7.147   -30.27  13.43   1    34.13  ? 1906 HOH A O      1 ? 
HETATM 6341 H H1     . HOH E 4 .   ? 7.527   -30.823 12.715  1    35.902 ? 1906 HOH A H1     1 ? 
HETATM 6342 H H2     . HOH E 4 .   ? 6.678   -29.538 13.004  1    34.696 ? 1906 HOH A H2     1 ? 
HETATM 6343 O O      . HOH E 4 .   ? 41.561  -19.499 22.737  1    23.963 ? 1907 HOH A O      1 ? 
HETATM 6344 H H1     . HOH E 4 .   ? 41.519  -20.434 22.457  1    24.296 ? 1907 HOH A H1     1 ? 
HETATM 6345 H H2     . HOH E 4 .   ? 41.06   -19.441 23.58   1    25.188 ? 1907 HOH A H2     1 ? 
HETATM 6346 O O      . HOH E 4 .   ? 33.328  -36.854 18.002  1    55.104 ? 1908 HOH A O      1 ? 
HETATM 6347 H H1     . HOH E 4 .   ? 33.713  -36.579 17.141  1    50.979 ? 1908 HOH A H1     1 ? 
HETATM 6348 H H2     . HOH E 4 .   ? 32.369  -37.036 17.891  1    51.546 ? 1908 HOH A H2     1 ? 
HETATM 6349 O O      . HOH E 4 .   ? 28.416  -30.388 8.064   1    43.199 ? 1909 HOH A O      1 ? 
HETATM 6350 H H1     . HOH E 4 .   ? 29.359  -30.628 8.175   1    41.191 ? 1909 HOH A H1     1 ? 
HETATM 6351 H H2     . HOH E 4 .   ? 27.861  -31.181 8.235   1    38.529 ? 1909 HOH A H2     1 ? 
HETATM 6352 O O      . HOH E 4 .   ? 40.261  -21.096 6.234   1    42.674 ? 1910 HOH A O      1 ? 
HETATM 6353 H H1     . HOH E 4 .   ? 39.864  -21.976 6.012   1    39.96  ? 1910 HOH A H1     1 ? 
HETATM 6354 H H2     . HOH E 4 .   ? 40.341  -20.547 5.423   1    41.066 ? 1910 HOH A H2     1 ? 
HETATM 6355 O O      . HOH E 4 .   ? 25.665  -29.653 2.029   1    40.581 ? 1911 HOH A O      1 ? 
HETATM 6356 H H1     . HOH E 4 .   ? 26.364  -30.006 1.449   1    40.689 ? 1911 HOH A H1     1 ? 
HETATM 6357 H H2     . HOH E 4 .   ? 24.993  -29.239 1.446   1    39.039 ? 1911 HOH A H2     1 ? 
HETATM 6358 O O      . HOH E 4 .   ? 29.319  -8.811  -10.765 1    30.877 ? 1912 HOH A O      1 ? 
HETATM 6359 H H1     . HOH E 4 .   ? 28.404  -9.076  -10.544 1    28.878 ? 1912 HOH A H1     1 ? 
HETATM 6360 H H2     . HOH E 4 .   ? 29.305  -7.872  -11.021 1    31.587 ? 1912 HOH A H2     1 ? 
HETATM 6361 O O      . HOH E 4 .   ? 2.253   2.049   24.105  1    59.337 ? 1913 HOH A O      1 ? 
HETATM 6362 H H1     . HOH E 4 .   ? 1.709   1.895   23.304  1    49.796 ? 1913 HOH A H1     1 ? 
HETATM 6363 H H2     . HOH E 4 .   ? 3.18    2.191   23.826  1    58.876 ? 1913 HOH A H2     1 ? 
# 
