data_9KJU
# 
_entry.id   9KJU 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9KJU         pdb_00009kju 10.2210/pdb9kju/pdb 
WWPDB D_1300053708 ?            ?                   
EMDB  EMD-62377    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9KJU 
_pdbx_database_status.recvd_initial_deposition_date   2024-11-12 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Local refinement of the y+LAT1-4F2hc bound with Arg' 
_pdbx_database_related.db_id          EMD-62377 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              yanrh@sustech.edu.cn 
_pdbx_contact_author.name_first         R.H. 
_pdbx_contact_author.name_last          Yan 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-7122-6547 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Yan, R.H.'   1 0000-0002-7122-6547 
'Dai, L.'     2 0009-0001-0330-7994 
'Zhang, Y.Y.' 3 0000-0002-2500-0010 
'Zhang, T.'   4 0009-0003-0124-6758 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Sci Adv' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2375-2548 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            11 
_citation.language                  ? 
_citation.page_first                eadq0558 
_citation.page_last                 eadq0558 
_citation.title                     
'Structural basis for the substrate recognition and transport mechanism of the human y + LAT1-4F2hc transporter complex.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1126/sciadv.adq0558 
_citation.pdbx_database_id_PubMed   40106545 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Dai, L.'   1  0009-0001-0330-7994 
primary 'Zeng, Q.'  2  0009-0000-8001-5752 
primary 'Zhang, T.' 3  0009-0003-0124-6758 
primary 'Zhang, Y.' 4  0000-0002-2500-0010 
primary 'Shi, Y.'   5  0000-0002-6281-8911 
primary 'Li, Y.'    6  0000-0003-3245-3023 
primary 'Xu, K.'    7  0009-0006-8462-6212 
primary 'Huang, J.' 8  0000-0001-9639-2907 
primary 'Wang, Z.'  9  0000-0001-7473-0354 
primary 'Zhou, Q.'  10 0000-0002-6237-8813 
primary 'Yan, R.'   11 0000-0002-7122-6547 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Amino acid transporter heavy chain SLC3A2'                                               69837.523 1 ? ? ? ? 
2 polymer     man 'Y+L amino acid transporter 1'                                                            57963.137 1 ? ? ? ? 
3 branched    man '2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose' 424.401   4 ? ? ? ? 
4 non-polymer syn ARGININE                                                                                  175.209   1 ? ? ? ? 
5 water       nat water                                                                                     18.015    1 ? ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 
;4F2 cell-surface antigen heavy chain,4F2hc,4F2 heavy chain antigen,Lymphocyte activation antigen 4F2 large subunit,Solute carrier family 3 member 2
;
2 'Monocyte amino acid permease 2,MOP-2,Solute carrier family 7 member 7,y(+)L-type amino acid transporter 1,Y+LAT1,y+LAT-1' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;HHHHHHHHHHSGRELQPPEASIAVVSIPRQLPGSHSEAGVQGLSAGDDSELGSHCVAQTGLELLASGDPLPSASQNAEMI
ETGSDCVTQAGLQLLASSDPPALASKNAEVTGTMSQDTEVDMKEVELNELEPEKQPMNAASGAAMSLAGAEKNGLVKIKV
AEDEAEAAAAAKFTGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPAQKWWHTGALYRIG
DLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQTDLLQIDPNFGSKEDFDSLLQSAKKKSIRVILDL
TPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSDLQQI
LSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLMLFTLPGTPVFSY
GDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFSAGP
GLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPY
AATGA
;
;HHHHHHHHHHSGRELQPPEASIAVVSIPRQLPGSHSEAGVQGLSAGDDSELGSHCVAQTGLELLASGDPLPSASQNAEMI
ETGSDCVTQAGLQLLASSDPPALASKNAEVTGTMSQDTEVDMKEVELNELEPEKQPMNAASGAAMSLAGAEKNGLVKIKV
AEDEAEAAAAAKFTGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPAQKWWHTGALYRIG
DLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQTDLLQIDPNFGSKEDFDSLLQSAKKKSIRVILDL
TPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSDLQQI
LSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLMLFTLPGTPVFSY
GDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFSAGP
GLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPY
AATGA
;
A ? 
2 'polypeptide(L)' no no 
;DYKDDDDKSGPDEVDASGRVDSTEYEVASQPEVETSPLGDGASPGPEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGV
LIYSASFGLSLVIWAVGGLFSVFGALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLLIIEPTSQAIIAITFANY
MVQPLFPSCFAPYAASRLLAAACICLLTFINCAYVKWGTLVQDIFTYAKVLALIAVIVAGIVRLGQGASTHFENSFEGSS
FAVGDIALALYSALFSYSGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYTVLDMRDILASDAVAVTFAD
QIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGHLPDAICMIHVERFTPVPSLLFNGIMALIYLCVEDIFQLI
NYYSFSYWFFVGLSIVGQLYLRWKEPDRPRPLKLSVFFPIVFCLCTIFLVAVPLYSDTINSLIGIAIALSGLPFYFLIIR
VPEHKRPLYLRRIVGSATRYLQVLCMSVAAEMDLEDGGEMPKQRDPKSN
;
;DYKDDDDKSGPDEVDASGRVDSTEYEVASQPEVETSPLGDGASPGPEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGV
LIYSASFGLSLVIWAVGGLFSVFGALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLLIIEPTSQAIIAITFANY
MVQPLFPSCFAPYAASRLLAAACICLLTFINCAYVKWGTLVQDIFTYAKVLALIAVIVAGIVRLGQGASTHFENSFEGSS
FAVGDIALALYSALFSYSGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYTVLDMRDILASDAVAVTFAD
QIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGHLPDAICMIHVERFTPVPSLLFNGIMALIYLCVEDIFQLI
NYYSFSYWFFVGLSIVGQLYLRWKEPDRPRPLKLSVFFPIVFCLCTIFLVAVPLYSDTINSLIGIAIALSGLPFYFLIIR
VPEHKRPLYLRRIVGSATRYLQVLCMSVAAEMDLEDGGEMPKQRDPKSN
;
B ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
4 ARGININE ARG 
5 water    HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   HIS n 
1 2   HIS n 
1 3   HIS n 
1 4   HIS n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   HIS n 
1 10  HIS n 
1 11  SER n 
1 12  GLY n 
1 13  ARG n 
1 14  GLU n 
1 15  LEU n 
1 16  GLN n 
1 17  PRO n 
1 18  PRO n 
1 19  GLU n 
1 20  ALA n 
1 21  SER n 
1 22  ILE n 
1 23  ALA n 
1 24  VAL n 
1 25  VAL n 
1 26  SER n 
1 27  ILE n 
1 28  PRO n 
1 29  ARG n 
1 30  GLN n 
1 31  LEU n 
1 32  PRO n 
1 33  GLY n 
1 34  SER n 
1 35  HIS n 
1 36  SER n 
1 37  GLU n 
1 38  ALA n 
1 39  GLY n 
1 40  VAL n 
1 41  GLN n 
1 42  GLY n 
1 43  LEU n 
1 44  SER n 
1 45  ALA n 
1 46  GLY n 
1 47  ASP n 
1 48  ASP n 
1 49  SER n 
1 50  GLU n 
1 51  LEU n 
1 52  GLY n 
1 53  SER n 
1 54  HIS n 
1 55  CYS n 
1 56  VAL n 
1 57  ALA n 
1 58  GLN n 
1 59  THR n 
1 60  GLY n 
1 61  LEU n 
1 62  GLU n 
1 63  LEU n 
1 64  LEU n 
1 65  ALA n 
1 66  SER n 
1 67  GLY n 
1 68  ASP n 
1 69  PRO n 
1 70  LEU n 
1 71  PRO n 
1 72  SER n 
1 73  ALA n 
1 74  SER n 
1 75  GLN n 
1 76  ASN n 
1 77  ALA n 
1 78  GLU n 
1 79  MET n 
1 80  ILE n 
1 81  GLU n 
1 82  THR n 
1 83  GLY n 
1 84  SER n 
1 85  ASP n 
1 86  CYS n 
1 87  VAL n 
1 88  THR n 
1 89  GLN n 
1 90  ALA n 
1 91  GLY n 
1 92  LEU n 
1 93  GLN n 
1 94  LEU n 
1 95  LEU n 
1 96  ALA n 
1 97  SER n 
1 98  SER n 
1 99  ASP n 
1 100 PRO n 
1 101 PRO n 
1 102 ALA n 
1 103 LEU n 
1 104 ALA n 
1 105 SER n 
1 106 LYS n 
1 107 ASN n 
1 108 ALA n 
1 109 GLU n 
1 110 VAL n 
1 111 THR n 
1 112 GLY n 
1 113 THR n 
1 114 MET n 
1 115 SER n 
1 116 GLN n 
1 117 ASP n 
1 118 THR n 
1 119 GLU n 
1 120 VAL n 
1 121 ASP n 
1 122 MET n 
1 123 LYS n 
1 124 GLU n 
1 125 VAL n 
1 126 GLU n 
1 127 LEU n 
1 128 ASN n 
1 129 GLU n 
1 130 LEU n 
1 131 GLU n 
1 132 PRO n 
1 133 GLU n 
1 134 LYS n 
1 135 GLN n 
1 136 PRO n 
1 137 MET n 
1 138 ASN n 
1 139 ALA n 
1 140 ALA n 
1 141 SER n 
1 142 GLY n 
1 143 ALA n 
1 144 ALA n 
1 145 MET n 
1 146 SER n 
1 147 LEU n 
1 148 ALA n 
1 149 GLY n 
1 150 ALA n 
1 151 GLU n 
1 152 LYS n 
1 153 ASN n 
1 154 GLY n 
1 155 LEU n 
1 156 VAL n 
1 157 LYS n 
1 158 ILE n 
1 159 LYS n 
1 160 VAL n 
1 161 ALA n 
1 162 GLU n 
1 163 ASP n 
1 164 GLU n 
1 165 ALA n 
1 166 GLU n 
1 167 ALA n 
1 168 ALA n 
1 169 ALA n 
1 170 ALA n 
1 171 ALA n 
1 172 LYS n 
1 173 PHE n 
1 174 THR n 
1 175 GLY n 
1 176 LEU n 
1 177 SER n 
1 178 LYS n 
1 179 GLU n 
1 180 GLU n 
1 181 LEU n 
1 182 LEU n 
1 183 LYS n 
1 184 VAL n 
1 185 ALA n 
1 186 GLY n 
1 187 SER n 
1 188 PRO n 
1 189 GLY n 
1 190 TRP n 
1 191 VAL n 
1 192 ARG n 
1 193 THR n 
1 194 ARG n 
1 195 TRP n 
1 196 ALA n 
1 197 LEU n 
1 198 LEU n 
1 199 LEU n 
1 200 LEU n 
1 201 PHE n 
1 202 TRP n 
1 203 LEU n 
1 204 GLY n 
1 205 TRP n 
1 206 LEU n 
1 207 GLY n 
1 208 MET n 
1 209 LEU n 
1 210 ALA n 
1 211 GLY n 
1 212 ALA n 
1 213 VAL n 
1 214 VAL n 
1 215 ILE n 
1 216 ILE n 
1 217 VAL n 
1 218 ARG n 
1 219 ALA n 
1 220 PRO n 
1 221 ARG n 
1 222 CYS n 
1 223 ARG n 
1 224 GLU n 
1 225 LEU n 
1 226 PRO n 
1 227 ALA n 
1 228 GLN n 
1 229 LYS n 
1 230 TRP n 
1 231 TRP n 
1 232 HIS n 
1 233 THR n 
1 234 GLY n 
1 235 ALA n 
1 236 LEU n 
1 237 TYR n 
1 238 ARG n 
1 239 ILE n 
1 240 GLY n 
1 241 ASP n 
1 242 LEU n 
1 243 GLN n 
1 244 ALA n 
1 245 PHE n 
1 246 GLN n 
1 247 GLY n 
1 248 HIS n 
1 249 GLY n 
1 250 ALA n 
1 251 GLY n 
1 252 ASN n 
1 253 LEU n 
1 254 ALA n 
1 255 GLY n 
1 256 LEU n 
1 257 LYS n 
1 258 GLY n 
1 259 ARG n 
1 260 LEU n 
1 261 ASP n 
1 262 TYR n 
1 263 LEU n 
1 264 SER n 
1 265 SER n 
1 266 LEU n 
1 267 LYS n 
1 268 VAL n 
1 269 LYS n 
1 270 GLY n 
1 271 LEU n 
1 272 VAL n 
1 273 LEU n 
1 274 GLY n 
1 275 PRO n 
1 276 ILE n 
1 277 HIS n 
1 278 LYS n 
1 279 ASN n 
1 280 GLN n 
1 281 LYS n 
1 282 ASP n 
1 283 ASP n 
1 284 VAL n 
1 285 ALA n 
1 286 GLN n 
1 287 THR n 
1 288 ASP n 
1 289 LEU n 
1 290 LEU n 
1 291 GLN n 
1 292 ILE n 
1 293 ASP n 
1 294 PRO n 
1 295 ASN n 
1 296 PHE n 
1 297 GLY n 
1 298 SER n 
1 299 LYS n 
1 300 GLU n 
1 301 ASP n 
1 302 PHE n 
1 303 ASP n 
1 304 SER n 
1 305 LEU n 
1 306 LEU n 
1 307 GLN n 
1 308 SER n 
1 309 ALA n 
1 310 LYS n 
1 311 LYS n 
1 312 LYS n 
1 313 SER n 
1 314 ILE n 
1 315 ARG n 
1 316 VAL n 
1 317 ILE n 
1 318 LEU n 
1 319 ASP n 
1 320 LEU n 
1 321 THR n 
1 322 PRO n 
1 323 ASN n 
1 324 TYR n 
1 325 ARG n 
1 326 GLY n 
1 327 GLU n 
1 328 ASN n 
1 329 SER n 
1 330 TRP n 
1 331 PHE n 
1 332 SER n 
1 333 THR n 
1 334 GLN n 
1 335 VAL n 
1 336 ASP n 
1 337 THR n 
1 338 VAL n 
1 339 ALA n 
1 340 THR n 
1 341 LYS n 
1 342 VAL n 
1 343 LYS n 
1 344 ASP n 
1 345 ALA n 
1 346 LEU n 
1 347 GLU n 
1 348 PHE n 
1 349 TRP n 
1 350 LEU n 
1 351 GLN n 
1 352 ALA n 
1 353 GLY n 
1 354 VAL n 
1 355 ASP n 
1 356 GLY n 
1 357 PHE n 
1 358 GLN n 
1 359 VAL n 
1 360 ARG n 
1 361 ASP n 
1 362 ILE n 
1 363 GLU n 
1 364 ASN n 
1 365 LEU n 
1 366 LYS n 
1 367 ASP n 
1 368 ALA n 
1 369 SER n 
1 370 SER n 
1 371 PHE n 
1 372 LEU n 
1 373 ALA n 
1 374 GLU n 
1 375 TRP n 
1 376 GLN n 
1 377 ASN n 
1 378 ILE n 
1 379 THR n 
1 380 LYS n 
1 381 GLY n 
1 382 PHE n 
1 383 SER n 
1 384 GLU n 
1 385 ASP n 
1 386 ARG n 
1 387 LEU n 
1 388 LEU n 
1 389 ILE n 
1 390 ALA n 
1 391 GLY n 
1 392 THR n 
1 393 ASN n 
1 394 SER n 
1 395 SER n 
1 396 ASP n 
1 397 LEU n 
1 398 GLN n 
1 399 GLN n 
1 400 ILE n 
1 401 LEU n 
1 402 SER n 
1 403 LEU n 
1 404 LEU n 
1 405 GLU n 
1 406 SER n 
1 407 ASN n 
1 408 LYS n 
1 409 ASP n 
1 410 LEU n 
1 411 LEU n 
1 412 LEU n 
1 413 THR n 
1 414 SER n 
1 415 SER n 
1 416 TYR n 
1 417 LEU n 
1 418 SER n 
1 419 ASP n 
1 420 SER n 
1 421 GLY n 
1 422 SER n 
1 423 THR n 
1 424 GLY n 
1 425 GLU n 
1 426 HIS n 
1 427 THR n 
1 428 LYS n 
1 429 SER n 
1 430 LEU n 
1 431 VAL n 
1 432 THR n 
1 433 GLN n 
1 434 TYR n 
1 435 LEU n 
1 436 ASN n 
1 437 ALA n 
1 438 THR n 
1 439 GLY n 
1 440 ASN n 
1 441 ARG n 
1 442 TRP n 
1 443 CYS n 
1 444 SER n 
1 445 TRP n 
1 446 SER n 
1 447 LEU n 
1 448 SER n 
1 449 GLN n 
1 450 ALA n 
1 451 ARG n 
1 452 LEU n 
1 453 LEU n 
1 454 THR n 
1 455 SER n 
1 456 PHE n 
1 457 LEU n 
1 458 PRO n 
1 459 ALA n 
1 460 GLN n 
1 461 LEU n 
1 462 LEU n 
1 463 ARG n 
1 464 LEU n 
1 465 TYR n 
1 466 GLN n 
1 467 LEU n 
1 468 MET n 
1 469 LEU n 
1 470 PHE n 
1 471 THR n 
1 472 LEU n 
1 473 PRO n 
1 474 GLY n 
1 475 THR n 
1 476 PRO n 
1 477 VAL n 
1 478 PHE n 
1 479 SER n 
1 480 TYR n 
1 481 GLY n 
1 482 ASP n 
1 483 GLU n 
1 484 ILE n 
1 485 GLY n 
1 486 LEU n 
1 487 ASP n 
1 488 ALA n 
1 489 ALA n 
1 490 ALA n 
1 491 LEU n 
1 492 PRO n 
1 493 GLY n 
1 494 GLN n 
1 495 PRO n 
1 496 MET n 
1 497 GLU n 
1 498 ALA n 
1 499 PRO n 
1 500 VAL n 
1 501 MET n 
1 502 LEU n 
1 503 TRP n 
1 504 ASP n 
1 505 GLU n 
1 506 SER n 
1 507 SER n 
1 508 PHE n 
1 509 PRO n 
1 510 ASP n 
1 511 ILE n 
1 512 PRO n 
1 513 GLY n 
1 514 ALA n 
1 515 VAL n 
1 516 SER n 
1 517 ALA n 
1 518 ASN n 
1 519 MET n 
1 520 THR n 
1 521 VAL n 
1 522 LYS n 
1 523 GLY n 
1 524 GLN n 
1 525 SER n 
1 526 GLU n 
1 527 ASP n 
1 528 PRO n 
1 529 GLY n 
1 530 SER n 
1 531 LEU n 
1 532 LEU n 
1 533 SER n 
1 534 LEU n 
1 535 PHE n 
1 536 ARG n 
1 537 ARG n 
1 538 LEU n 
1 539 SER n 
1 540 ASP n 
1 541 GLN n 
1 542 ARG n 
1 543 SER n 
1 544 LYS n 
1 545 GLU n 
1 546 ARG n 
1 547 SER n 
1 548 LEU n 
1 549 LEU n 
1 550 HIS n 
1 551 GLY n 
1 552 ASP n 
1 553 PHE n 
1 554 HIS n 
1 555 ALA n 
1 556 PHE n 
1 557 SER n 
1 558 ALA n 
1 559 GLY n 
1 560 PRO n 
1 561 GLY n 
1 562 LEU n 
1 563 PHE n 
1 564 SER n 
1 565 TYR n 
1 566 ILE n 
1 567 ARG n 
1 568 HIS n 
1 569 TRP n 
1 570 ASP n 
1 571 GLN n 
1 572 ASN n 
1 573 GLU n 
1 574 ARG n 
1 575 PHE n 
1 576 LEU n 
1 577 VAL n 
1 578 VAL n 
1 579 LEU n 
1 580 ASN n 
1 581 PHE n 
1 582 GLY n 
1 583 ASP n 
1 584 VAL n 
1 585 GLY n 
1 586 LEU n 
1 587 SER n 
1 588 ALA n 
1 589 GLY n 
1 590 LEU n 
1 591 GLN n 
1 592 ALA n 
1 593 SER n 
1 594 ASP n 
1 595 LEU n 
1 596 PRO n 
1 597 ALA n 
1 598 SER n 
1 599 ALA n 
1 600 SER n 
1 601 LEU n 
1 602 PRO n 
1 603 ALA n 
1 604 LYS n 
1 605 ALA n 
1 606 ASP n 
1 607 LEU n 
1 608 LEU n 
1 609 LEU n 
1 610 SER n 
1 611 THR n 
1 612 GLN n 
1 613 PRO n 
1 614 GLY n 
1 615 ARG n 
1 616 GLU n 
1 617 GLU n 
1 618 GLY n 
1 619 SER n 
1 620 PRO n 
1 621 LEU n 
1 622 GLU n 
1 623 LEU n 
1 624 GLU n 
1 625 ARG n 
1 626 LEU n 
1 627 LYS n 
1 628 LEU n 
1 629 GLU n 
1 630 PRO n 
1 631 HIS n 
1 632 GLU n 
1 633 GLY n 
1 634 LEU n 
1 635 LEU n 
1 636 LEU n 
1 637 ARG n 
1 638 PHE n 
1 639 PRO n 
1 640 TYR n 
1 641 ALA n 
1 642 ALA n 
1 643 THR n 
1 644 GLY n 
1 645 ALA n 
2 1   ASP n 
2 2   TYR n 
2 3   LYS n 
2 4   ASP n 
2 5   ASP n 
2 6   ASP n 
2 7   ASP n 
2 8   LYS n 
2 9   SER n 
2 10  GLY n 
2 11  PRO n 
2 12  ASP n 
2 13  GLU n 
2 14  VAL n 
2 15  ASP n 
2 16  ALA n 
2 17  SER n 
2 18  GLY n 
2 19  ARG n 
2 20  VAL n 
2 21  ASP n 
2 22  SER n 
2 23  THR n 
2 24  GLU n 
2 25  TYR n 
2 26  GLU n 
2 27  VAL n 
2 28  ALA n 
2 29  SER n 
2 30  GLN n 
2 31  PRO n 
2 32  GLU n 
2 33  VAL n 
2 34  GLU n 
2 35  THR n 
2 36  SER n 
2 37  PRO n 
2 38  LEU n 
2 39  GLY n 
2 40  ASP n 
2 41  GLY n 
2 42  ALA n 
2 43  SER n 
2 44  PRO n 
2 45  GLY n 
2 46  PRO n 
2 47  GLU n 
2 48  GLN n 
2 49  VAL n 
2 50  LYS n 
2 51  LEU n 
2 52  LYS n 
2 53  LYS n 
2 54  GLU n 
2 55  ILE n 
2 56  SER n 
2 57  LEU n 
2 58  LEU n 
2 59  ASN n 
2 60  GLY n 
2 61  VAL n 
2 62  CYS n 
2 63  LEU n 
2 64  ILE n 
2 65  VAL n 
2 66  GLY n 
2 67  ASN n 
2 68  MET n 
2 69  ILE n 
2 70  GLY n 
2 71  SER n 
2 72  GLY n 
2 73  ILE n 
2 74  PHE n 
2 75  VAL n 
2 76  SER n 
2 77  PRO n 
2 78  LYS n 
2 79  GLY n 
2 80  VAL n 
2 81  LEU n 
2 82  ILE n 
2 83  TYR n 
2 84  SER n 
2 85  ALA n 
2 86  SER n 
2 87  PHE n 
2 88  GLY n 
2 89  LEU n 
2 90  SER n 
2 91  LEU n 
2 92  VAL n 
2 93  ILE n 
2 94  TRP n 
2 95  ALA n 
2 96  VAL n 
2 97  GLY n 
2 98  GLY n 
2 99  LEU n 
2 100 PHE n 
2 101 SER n 
2 102 VAL n 
2 103 PHE n 
2 104 GLY n 
2 105 ALA n 
2 106 LEU n 
2 107 CYS n 
2 108 TYR n 
2 109 ALA n 
2 110 GLU n 
2 111 LEU n 
2 112 GLY n 
2 113 THR n 
2 114 THR n 
2 115 ILE n 
2 116 LYS n 
2 117 LYS n 
2 118 SER n 
2 119 GLY n 
2 120 ALA n 
2 121 SER n 
2 122 TYR n 
2 123 ALA n 
2 124 TYR n 
2 125 ILE n 
2 126 LEU n 
2 127 GLU n 
2 128 ALA n 
2 129 PHE n 
2 130 GLY n 
2 131 GLY n 
2 132 PHE n 
2 133 LEU n 
2 134 ALA n 
2 135 PHE n 
2 136 ILE n 
2 137 ARG n 
2 138 LEU n 
2 139 TRP n 
2 140 THR n 
2 141 SER n 
2 142 LEU n 
2 143 LEU n 
2 144 ILE n 
2 145 ILE n 
2 146 GLU n 
2 147 PRO n 
2 148 THR n 
2 149 SER n 
2 150 GLN n 
2 151 ALA n 
2 152 ILE n 
2 153 ILE n 
2 154 ALA n 
2 155 ILE n 
2 156 THR n 
2 157 PHE n 
2 158 ALA n 
2 159 ASN n 
2 160 TYR n 
2 161 MET n 
2 162 VAL n 
2 163 GLN n 
2 164 PRO n 
2 165 LEU n 
2 166 PHE n 
2 167 PRO n 
2 168 SER n 
2 169 CYS n 
2 170 PHE n 
2 171 ALA n 
2 172 PRO n 
2 173 TYR n 
2 174 ALA n 
2 175 ALA n 
2 176 SER n 
2 177 ARG n 
2 178 LEU n 
2 179 LEU n 
2 180 ALA n 
2 181 ALA n 
2 182 ALA n 
2 183 CYS n 
2 184 ILE n 
2 185 CYS n 
2 186 LEU n 
2 187 LEU n 
2 188 THR n 
2 189 PHE n 
2 190 ILE n 
2 191 ASN n 
2 192 CYS n 
2 193 ALA n 
2 194 TYR n 
2 195 VAL n 
2 196 LYS n 
2 197 TRP n 
2 198 GLY n 
2 199 THR n 
2 200 LEU n 
2 201 VAL n 
2 202 GLN n 
2 203 ASP n 
2 204 ILE n 
2 205 PHE n 
2 206 THR n 
2 207 TYR n 
2 208 ALA n 
2 209 LYS n 
2 210 VAL n 
2 211 LEU n 
2 212 ALA n 
2 213 LEU n 
2 214 ILE n 
2 215 ALA n 
2 216 VAL n 
2 217 ILE n 
2 218 VAL n 
2 219 ALA n 
2 220 GLY n 
2 221 ILE n 
2 222 VAL n 
2 223 ARG n 
2 224 LEU n 
2 225 GLY n 
2 226 GLN n 
2 227 GLY n 
2 228 ALA n 
2 229 SER n 
2 230 THR n 
2 231 HIS n 
2 232 PHE n 
2 233 GLU n 
2 234 ASN n 
2 235 SER n 
2 236 PHE n 
2 237 GLU n 
2 238 GLY n 
2 239 SER n 
2 240 SER n 
2 241 PHE n 
2 242 ALA n 
2 243 VAL n 
2 244 GLY n 
2 245 ASP n 
2 246 ILE n 
2 247 ALA n 
2 248 LEU n 
2 249 ALA n 
2 250 LEU n 
2 251 TYR n 
2 252 SER n 
2 253 ALA n 
2 254 LEU n 
2 255 PHE n 
2 256 SER n 
2 257 TYR n 
2 258 SER n 
2 259 GLY n 
2 260 TRP n 
2 261 ASP n 
2 262 THR n 
2 263 LEU n 
2 264 ASN n 
2 265 TYR n 
2 266 VAL n 
2 267 THR n 
2 268 GLU n 
2 269 GLU n 
2 270 ILE n 
2 271 LYS n 
2 272 ASN n 
2 273 PRO n 
2 274 GLU n 
2 275 ARG n 
2 276 ASN n 
2 277 LEU n 
2 278 PRO n 
2 279 LEU n 
2 280 SER n 
2 281 ILE n 
2 282 GLY n 
2 283 ILE n 
2 284 SER n 
2 285 MET n 
2 286 PRO n 
2 287 ILE n 
2 288 VAL n 
2 289 THR n 
2 290 ILE n 
2 291 ILE n 
2 292 TYR n 
2 293 ILE n 
2 294 LEU n 
2 295 THR n 
2 296 ASN n 
2 297 VAL n 
2 298 ALA n 
2 299 TYR n 
2 300 TYR n 
2 301 THR n 
2 302 VAL n 
2 303 LEU n 
2 304 ASP n 
2 305 MET n 
2 306 ARG n 
2 307 ASP n 
2 308 ILE n 
2 309 LEU n 
2 310 ALA n 
2 311 SER n 
2 312 ASP n 
2 313 ALA n 
2 314 VAL n 
2 315 ALA n 
2 316 VAL n 
2 317 THR n 
2 318 PHE n 
2 319 ALA n 
2 320 ASP n 
2 321 GLN n 
2 322 ILE n 
2 323 PHE n 
2 324 GLY n 
2 325 ILE n 
2 326 PHE n 
2 327 ASN n 
2 328 TRP n 
2 329 ILE n 
2 330 ILE n 
2 331 PRO n 
2 332 LEU n 
2 333 SER n 
2 334 VAL n 
2 335 ALA n 
2 336 LEU n 
2 337 SER n 
2 338 CYS n 
2 339 PHE n 
2 340 GLY n 
2 341 GLY n 
2 342 LEU n 
2 343 ASN n 
2 344 ALA n 
2 345 SER n 
2 346 ILE n 
2 347 VAL n 
2 348 ALA n 
2 349 ALA n 
2 350 SER n 
2 351 ARG n 
2 352 LEU n 
2 353 PHE n 
2 354 PHE n 
2 355 VAL n 
2 356 GLY n 
2 357 SER n 
2 358 ARG n 
2 359 GLU n 
2 360 GLY n 
2 361 HIS n 
2 362 LEU n 
2 363 PRO n 
2 364 ASP n 
2 365 ALA n 
2 366 ILE n 
2 367 CYS n 
2 368 MET n 
2 369 ILE n 
2 370 HIS n 
2 371 VAL n 
2 372 GLU n 
2 373 ARG n 
2 374 PHE n 
2 375 THR n 
2 376 PRO n 
2 377 VAL n 
2 378 PRO n 
2 379 SER n 
2 380 LEU n 
2 381 LEU n 
2 382 PHE n 
2 383 ASN n 
2 384 GLY n 
2 385 ILE n 
2 386 MET n 
2 387 ALA n 
2 388 LEU n 
2 389 ILE n 
2 390 TYR n 
2 391 LEU n 
2 392 CYS n 
2 393 VAL n 
2 394 GLU n 
2 395 ASP n 
2 396 ILE n 
2 397 PHE n 
2 398 GLN n 
2 399 LEU n 
2 400 ILE n 
2 401 ASN n 
2 402 TYR n 
2 403 TYR n 
2 404 SER n 
2 405 PHE n 
2 406 SER n 
2 407 TYR n 
2 408 TRP n 
2 409 PHE n 
2 410 PHE n 
2 411 VAL n 
2 412 GLY n 
2 413 LEU n 
2 414 SER n 
2 415 ILE n 
2 416 VAL n 
2 417 GLY n 
2 418 GLN n 
2 419 LEU n 
2 420 TYR n 
2 421 LEU n 
2 422 ARG n 
2 423 TRP n 
2 424 LYS n 
2 425 GLU n 
2 426 PRO n 
2 427 ASP n 
2 428 ARG n 
2 429 PRO n 
2 430 ARG n 
2 431 PRO n 
2 432 LEU n 
2 433 LYS n 
2 434 LEU n 
2 435 SER n 
2 436 VAL n 
2 437 PHE n 
2 438 PHE n 
2 439 PRO n 
2 440 ILE n 
2 441 VAL n 
2 442 PHE n 
2 443 CYS n 
2 444 LEU n 
2 445 CYS n 
2 446 THR n 
2 447 ILE n 
2 448 PHE n 
2 449 LEU n 
2 450 VAL n 
2 451 ALA n 
2 452 VAL n 
2 453 PRO n 
2 454 LEU n 
2 455 TYR n 
2 456 SER n 
2 457 ASP n 
2 458 THR n 
2 459 ILE n 
2 460 ASN n 
2 461 SER n 
2 462 LEU n 
2 463 ILE n 
2 464 GLY n 
2 465 ILE n 
2 466 ALA n 
2 467 ILE n 
2 468 ALA n 
2 469 LEU n 
2 470 SER n 
2 471 GLY n 
2 472 LEU n 
2 473 PRO n 
2 474 PHE n 
2 475 TYR n 
2 476 PHE n 
2 477 LEU n 
2 478 ILE n 
2 479 ILE n 
2 480 ARG n 
2 481 VAL n 
2 482 PRO n 
2 483 GLU n 
2 484 HIS n 
2 485 LYS n 
2 486 ARG n 
2 487 PRO n 
2 488 LEU n 
2 489 TYR n 
2 490 LEU n 
2 491 ARG n 
2 492 ARG n 
2 493 ILE n 
2 494 VAL n 
2 495 GLY n 
2 496 SER n 
2 497 ALA n 
2 498 THR n 
2 499 ARG n 
2 500 TYR n 
2 501 LEU n 
2 502 GLN n 
2 503 VAL n 
2 504 LEU n 
2 505 CYS n 
2 506 MET n 
2 507 SER n 
2 508 VAL n 
2 509 ALA n 
2 510 ALA n 
2 511 GLU n 
2 512 MET n 
2 513 ASP n 
2 514 LEU n 
2 515 GLU n 
2 516 ASP n 
2 517 GLY n 
2 518 GLY n 
2 519 GLU n 
2 520 MET n 
2 521 PRO n 
2 522 LYS n 
2 523 GLN n 
2 524 ARG n 
2 525 ASP n 
2 526 PRO n 
2 527 LYS n 
2 528 SER n 
2 529 ASN n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 645 human ? 'SLC3A2, MDU1' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Homo sapiens' 9606 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 529 human ? SLC7A7         ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Homo sapiens' 9606 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
_pdbx_entity_branch.entity_id   3 
_pdbx_entity_branch.type        oligosaccharide 
# 
loop_
_pdbx_entity_branch_descriptor.ordinal 
_pdbx_entity_branch_descriptor.entity_id 
_pdbx_entity_branch_descriptor.descriptor 
_pdbx_entity_branch_descriptor.type 
_pdbx_entity_branch_descriptor.program 
_pdbx_entity_branch_descriptor.program_version 
1 3 DGlcpNAcb1-4DGlcpNAcb1-ROH                            'Glycam Condensed Sequence' GMML       1.0   
2 3 'WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1' WURCS                       PDB2Glycan 1.1.0 
3 3 '[][D-1-deoxy-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{}}'       LINUCS                      PDB-CARE   ?     
# 
_pdbx_entity_branch_link.link_id                    1 
_pdbx_entity_branch_link.entity_id                  3 
_pdbx_entity_branch_link.entity_branch_list_num_1   2 
_pdbx_entity_branch_link.comp_id_1                  NAG 
_pdbx_entity_branch_link.atom_id_1                  C1 
_pdbx_entity_branch_link.leaving_atom_id_1          O1 
_pdbx_entity_branch_link.entity_branch_list_num_2   1 
_pdbx_entity_branch_link.comp_id_2                  NAG 
_pdbx_entity_branch_link.atom_id_2                  O4 
_pdbx_entity_branch_link.leaving_atom_id_2          HO4 
_pdbx_entity_branch_link.value_order                sing 
_pdbx_entity_branch_link.details                    ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'          y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking'          y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking'          y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'          y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer                  . WATER                                    ? 'H2 O'           18.015  
ILE 'L-peptide linking'          y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'          y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'          y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'          y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   HIS 1   -10 ?   ?   ?   A . n 
A 1 2   HIS 2   -9  ?   ?   ?   A . n 
A 1 3   HIS 3   -8  ?   ?   ?   A . n 
A 1 4   HIS 4   -7  ?   ?   ?   A . n 
A 1 5   HIS 5   -6  ?   ?   ?   A . n 
A 1 6   HIS 6   -5  ?   ?   ?   A . n 
A 1 7   HIS 7   -4  ?   ?   ?   A . n 
A 1 8   HIS 8   -3  ?   ?   ?   A . n 
A 1 9   HIS 9   -2  ?   ?   ?   A . n 
A 1 10  HIS 10  -1  ?   ?   ?   A . n 
A 1 11  SER 11  0   ?   ?   ?   A . n 
A 1 12  GLY 12  1   ?   ?   ?   A . n 
A 1 13  ARG 13  2   ?   ?   ?   A . n 
A 1 14  GLU 14  3   ?   ?   ?   A . n 
A 1 15  LEU 15  4   ?   ?   ?   A . n 
A 1 16  GLN 16  5   ?   ?   ?   A . n 
A 1 17  PRO 17  6   ?   ?   ?   A . n 
A 1 18  PRO 18  7   ?   ?   ?   A . n 
A 1 19  GLU 19  8   ?   ?   ?   A . n 
A 1 20  ALA 20  9   ?   ?   ?   A . n 
A 1 21  SER 21  10  ?   ?   ?   A . n 
A 1 22  ILE 22  11  ?   ?   ?   A . n 
A 1 23  ALA 23  12  ?   ?   ?   A . n 
A 1 24  VAL 24  13  ?   ?   ?   A . n 
A 1 25  VAL 25  14  ?   ?   ?   A . n 
A 1 26  SER 26  15  ?   ?   ?   A . n 
A 1 27  ILE 27  16  ?   ?   ?   A . n 
A 1 28  PRO 28  17  ?   ?   ?   A . n 
A 1 29  ARG 29  18  ?   ?   ?   A . n 
A 1 30  GLN 30  19  ?   ?   ?   A . n 
A 1 31  LEU 31  20  ?   ?   ?   A . n 
A 1 32  PRO 32  21  ?   ?   ?   A . n 
A 1 33  GLY 33  22  ?   ?   ?   A . n 
A 1 34  SER 34  23  ?   ?   ?   A . n 
A 1 35  HIS 35  24  ?   ?   ?   A . n 
A 1 36  SER 36  25  ?   ?   ?   A . n 
A 1 37  GLU 37  26  ?   ?   ?   A . n 
A 1 38  ALA 38  27  ?   ?   ?   A . n 
A 1 39  GLY 39  28  ?   ?   ?   A . n 
A 1 40  VAL 40  29  ?   ?   ?   A . n 
A 1 41  GLN 41  30  ?   ?   ?   A . n 
A 1 42  GLY 42  31  ?   ?   ?   A . n 
A 1 43  LEU 43  32  ?   ?   ?   A . n 
A 1 44  SER 44  33  ?   ?   ?   A . n 
A 1 45  ALA 45  34  ?   ?   ?   A . n 
A 1 46  GLY 46  35  ?   ?   ?   A . n 
A 1 47  ASP 47  36  ?   ?   ?   A . n 
A 1 48  ASP 48  37  ?   ?   ?   A . n 
A 1 49  SER 49  38  ?   ?   ?   A . n 
A 1 50  GLU 50  39  ?   ?   ?   A . n 
A 1 51  LEU 51  40  ?   ?   ?   A . n 
A 1 52  GLY 52  41  ?   ?   ?   A . n 
A 1 53  SER 53  42  ?   ?   ?   A . n 
A 1 54  HIS 54  43  ?   ?   ?   A . n 
A 1 55  CYS 55  44  ?   ?   ?   A . n 
A 1 56  VAL 56  45  ?   ?   ?   A . n 
A 1 57  ALA 57  46  ?   ?   ?   A . n 
A 1 58  GLN 58  47  ?   ?   ?   A . n 
A 1 59  THR 59  48  ?   ?   ?   A . n 
A 1 60  GLY 60  49  ?   ?   ?   A . n 
A 1 61  LEU 61  50  ?   ?   ?   A . n 
A 1 62  GLU 62  51  ?   ?   ?   A . n 
A 1 63  LEU 63  52  ?   ?   ?   A . n 
A 1 64  LEU 64  53  ?   ?   ?   A . n 
A 1 65  ALA 65  54  ?   ?   ?   A . n 
A 1 66  SER 66  55  ?   ?   ?   A . n 
A 1 67  GLY 67  56  ?   ?   ?   A . n 
A 1 68  ASP 68  57  ?   ?   ?   A . n 
A 1 69  PRO 69  58  ?   ?   ?   A . n 
A 1 70  LEU 70  59  ?   ?   ?   A . n 
A 1 71  PRO 71  60  ?   ?   ?   A . n 
A 1 72  SER 72  61  ?   ?   ?   A . n 
A 1 73  ALA 73  62  ?   ?   ?   A . n 
A 1 74  SER 74  63  ?   ?   ?   A . n 
A 1 75  GLN 75  64  ?   ?   ?   A . n 
A 1 76  ASN 76  65  ?   ?   ?   A . n 
A 1 77  ALA 77  66  ?   ?   ?   A . n 
A 1 78  GLU 78  67  ?   ?   ?   A . n 
A 1 79  MET 79  68  ?   ?   ?   A . n 
A 1 80  ILE 80  69  ?   ?   ?   A . n 
A 1 81  GLU 81  70  ?   ?   ?   A . n 
A 1 82  THR 82  71  ?   ?   ?   A . n 
A 1 83  GLY 83  72  ?   ?   ?   A . n 
A 1 84  SER 84  73  ?   ?   ?   A . n 
A 1 85  ASP 85  74  ?   ?   ?   A . n 
A 1 86  CYS 86  75  ?   ?   ?   A . n 
A 1 87  VAL 87  76  ?   ?   ?   A . n 
A 1 88  THR 88  77  ?   ?   ?   A . n 
A 1 89  GLN 89  78  ?   ?   ?   A . n 
A 1 90  ALA 90  79  ?   ?   ?   A . n 
A 1 91  GLY 91  80  ?   ?   ?   A . n 
A 1 92  LEU 92  81  ?   ?   ?   A . n 
A 1 93  GLN 93  82  ?   ?   ?   A . n 
A 1 94  LEU 94  83  ?   ?   ?   A . n 
A 1 95  LEU 95  84  ?   ?   ?   A . n 
A 1 96  ALA 96  85  ?   ?   ?   A . n 
A 1 97  SER 97  86  ?   ?   ?   A . n 
A 1 98  SER 98  87  ?   ?   ?   A . n 
A 1 99  ASP 99  88  ?   ?   ?   A . n 
A 1 100 PRO 100 89  ?   ?   ?   A . n 
A 1 101 PRO 101 90  ?   ?   ?   A . n 
A 1 102 ALA 102 91  ?   ?   ?   A . n 
A 1 103 LEU 103 92  ?   ?   ?   A . n 
A 1 104 ALA 104 93  ?   ?   ?   A . n 
A 1 105 SER 105 94  ?   ?   ?   A . n 
A 1 106 LYS 106 95  ?   ?   ?   A . n 
A 1 107 ASN 107 96  ?   ?   ?   A . n 
A 1 108 ALA 108 97  ?   ?   ?   A . n 
A 1 109 GLU 109 98  ?   ?   ?   A . n 
A 1 110 VAL 110 99  ?   ?   ?   A . n 
A 1 111 THR 111 100 ?   ?   ?   A . n 
A 1 112 GLY 112 101 ?   ?   ?   A . n 
A 1 113 THR 113 102 ?   ?   ?   A . n 
A 1 114 MET 114 103 ?   ?   ?   A . n 
A 1 115 SER 115 104 ?   ?   ?   A . n 
A 1 116 GLN 116 105 ?   ?   ?   A . n 
A 1 117 ASP 117 106 ?   ?   ?   A . n 
A 1 118 THR 118 107 ?   ?   ?   A . n 
A 1 119 GLU 119 108 ?   ?   ?   A . n 
A 1 120 VAL 120 109 ?   ?   ?   A . n 
A 1 121 ASP 121 110 ?   ?   ?   A . n 
A 1 122 MET 122 111 ?   ?   ?   A . n 
A 1 123 LYS 123 112 ?   ?   ?   A . n 
A 1 124 GLU 124 113 ?   ?   ?   A . n 
A 1 125 VAL 125 114 ?   ?   ?   A . n 
A 1 126 GLU 126 115 ?   ?   ?   A . n 
A 1 127 LEU 127 116 ?   ?   ?   A . n 
A 1 128 ASN 128 117 ?   ?   ?   A . n 
A 1 129 GLU 129 118 ?   ?   ?   A . n 
A 1 130 LEU 130 119 ?   ?   ?   A . n 
A 1 131 GLU 131 120 ?   ?   ?   A . n 
A 1 132 PRO 132 121 ?   ?   ?   A . n 
A 1 133 GLU 133 122 ?   ?   ?   A . n 
A 1 134 LYS 134 123 ?   ?   ?   A . n 
A 1 135 GLN 135 124 ?   ?   ?   A . n 
A 1 136 PRO 136 125 ?   ?   ?   A . n 
A 1 137 MET 137 126 ?   ?   ?   A . n 
A 1 138 ASN 138 127 ?   ?   ?   A . n 
A 1 139 ALA 139 128 ?   ?   ?   A . n 
A 1 140 ALA 140 129 ?   ?   ?   A . n 
A 1 141 SER 141 130 ?   ?   ?   A . n 
A 1 142 GLY 142 131 ?   ?   ?   A . n 
A 1 143 ALA 143 132 ?   ?   ?   A . n 
A 1 144 ALA 144 133 ?   ?   ?   A . n 
A 1 145 MET 145 134 ?   ?   ?   A . n 
A 1 146 SER 146 135 ?   ?   ?   A . n 
A 1 147 LEU 147 136 ?   ?   ?   A . n 
A 1 148 ALA 148 137 ?   ?   ?   A . n 
A 1 149 GLY 149 138 ?   ?   ?   A . n 
A 1 150 ALA 150 139 ?   ?   ?   A . n 
A 1 151 GLU 151 140 ?   ?   ?   A . n 
A 1 152 LYS 152 141 ?   ?   ?   A . n 
A 1 153 ASN 153 142 ?   ?   ?   A . n 
A 1 154 GLY 154 143 ?   ?   ?   A . n 
A 1 155 LEU 155 144 ?   ?   ?   A . n 
A 1 156 VAL 156 145 ?   ?   ?   A . n 
A 1 157 LYS 157 146 ?   ?   ?   A . n 
A 1 158 ILE 158 147 ?   ?   ?   A . n 
A 1 159 LYS 159 148 ?   ?   ?   A . n 
A 1 160 VAL 160 149 ?   ?   ?   A . n 
A 1 161 ALA 161 150 ?   ?   ?   A . n 
A 1 162 GLU 162 151 ?   ?   ?   A . n 
A 1 163 ASP 163 152 ?   ?   ?   A . n 
A 1 164 GLU 164 153 ?   ?   ?   A . n 
A 1 165 ALA 165 154 ?   ?   ?   A . n 
A 1 166 GLU 166 155 ?   ?   ?   A . n 
A 1 167 ALA 167 156 ?   ?   ?   A . n 
A 1 168 ALA 168 157 ?   ?   ?   A . n 
A 1 169 ALA 169 158 ?   ?   ?   A . n 
A 1 170 ALA 170 159 ?   ?   ?   A . n 
A 1 171 ALA 171 160 ?   ?   ?   A . n 
A 1 172 LYS 172 161 161 LYS LYS A . n 
A 1 173 PHE 173 162 162 PHE PHE A . n 
A 1 174 THR 174 163 163 THR THR A . n 
A 1 175 GLY 175 164 164 GLY GLY A . n 
A 1 176 LEU 176 165 165 LEU LEU A . n 
A 1 177 SER 177 166 166 SER SER A . n 
A 1 178 LYS 178 167 167 LYS LYS A . n 
A 1 179 GLU 179 168 168 GLU GLU A . n 
A 1 180 GLU 180 169 169 GLU GLU A . n 
A 1 181 LEU 181 170 170 LEU LEU A . n 
A 1 182 LEU 182 171 171 LEU LEU A . n 
A 1 183 LYS 183 172 172 LYS LYS A . n 
A 1 184 VAL 184 173 173 VAL VAL A . n 
A 1 185 ALA 185 174 174 ALA ALA A . n 
A 1 186 GLY 186 175 175 GLY GLY A . n 
A 1 187 SER 187 176 176 SER SER A . n 
A 1 188 PRO 188 177 177 PRO PRO A . n 
A 1 189 GLY 189 178 178 GLY GLY A . n 
A 1 190 TRP 190 179 179 TRP TRP A . n 
A 1 191 VAL 191 180 180 VAL VAL A . n 
A 1 192 ARG 192 181 181 ARG ARG A . n 
A 1 193 THR 193 182 182 THR THR A . n 
A 1 194 ARG 194 183 183 ARG ARG A . n 
A 1 195 TRP 195 184 184 TRP TRP A . n 
A 1 196 ALA 196 185 185 ALA ALA A . n 
A 1 197 LEU 197 186 186 LEU LEU A . n 
A 1 198 LEU 198 187 187 LEU LEU A . n 
A 1 199 LEU 199 188 188 LEU LEU A . n 
A 1 200 LEU 200 189 189 LEU LEU A . n 
A 1 201 PHE 201 190 190 PHE PHE A . n 
A 1 202 TRP 202 191 191 TRP TRP A . n 
A 1 203 LEU 203 192 192 LEU LEU A . n 
A 1 204 GLY 204 193 193 GLY GLY A . n 
A 1 205 TRP 205 194 194 TRP TRP A . n 
A 1 206 LEU 206 195 195 LEU LEU A . n 
A 1 207 GLY 207 196 196 GLY GLY A . n 
A 1 208 MET 208 197 197 MET MET A . n 
A 1 209 LEU 209 198 198 LEU LEU A . n 
A 1 210 ALA 210 199 199 ALA ALA A . n 
A 1 211 GLY 211 200 200 GLY GLY A . n 
A 1 212 ALA 212 201 201 ALA ALA A . n 
A 1 213 VAL 213 202 202 VAL VAL A . n 
A 1 214 VAL 214 203 203 VAL VAL A . n 
A 1 215 ILE 215 204 204 ILE ILE A . n 
A 1 216 ILE 216 205 205 ILE ILE A . n 
A 1 217 VAL 217 206 206 VAL VAL A . n 
A 1 218 ARG 218 207 207 ARG ARG A . n 
A 1 219 ALA 219 208 208 ALA ALA A . n 
A 1 220 PRO 220 209 209 PRO PRO A . n 
A 1 221 ARG 221 210 210 ARG ARG A . n 
A 1 222 CYS 222 211 211 CYS CYS A . n 
A 1 223 ARG 223 212 212 ARG ARG A . n 
A 1 224 GLU 224 213 213 GLU GLU A . n 
A 1 225 LEU 225 214 214 LEU LEU A . n 
A 1 226 PRO 226 215 215 PRO PRO A . n 
A 1 227 ALA 227 216 216 ALA ALA A . n 
A 1 228 GLN 228 217 217 GLN GLN A . n 
A 1 229 LYS 229 218 218 LYS LYS A . n 
A 1 230 TRP 230 219 219 TRP TRP A . n 
A 1 231 TRP 231 220 220 TRP TRP A . n 
A 1 232 HIS 232 221 221 HIS HIS A . n 
A 1 233 THR 233 222 222 THR THR A . n 
A 1 234 GLY 234 223 223 GLY GLY A . n 
A 1 235 ALA 235 224 224 ALA ALA A . n 
A 1 236 LEU 236 225 225 LEU LEU A . n 
A 1 237 TYR 237 226 226 TYR TYR A . n 
A 1 238 ARG 238 227 227 ARG ARG A . n 
A 1 239 ILE 239 228 228 ILE ILE A . n 
A 1 240 GLY 240 229 229 GLY GLY A . n 
A 1 241 ASP 241 230 230 ASP ASP A . n 
A 1 242 LEU 242 231 231 LEU LEU A . n 
A 1 243 GLN 243 232 232 GLN GLN A . n 
A 1 244 ALA 244 233 233 ALA ALA A . n 
A 1 245 PHE 245 234 234 PHE PHE A . n 
A 1 246 GLN 246 235 235 GLN GLN A . n 
A 1 247 GLY 247 236 236 GLY GLY A . n 
A 1 248 HIS 248 237 237 HIS HIS A . n 
A 1 249 GLY 249 238 238 GLY GLY A . n 
A 1 250 ALA 250 239 239 ALA ALA A . n 
A 1 251 GLY 251 240 240 GLY GLY A . n 
A 1 252 ASN 252 241 241 ASN ASN A . n 
A 1 253 LEU 253 242 242 LEU LEU A . n 
A 1 254 ALA 254 243 243 ALA ALA A . n 
A 1 255 GLY 255 244 244 GLY GLY A . n 
A 1 256 LEU 256 245 245 LEU LEU A . n 
A 1 257 LYS 257 246 246 LYS LYS A . n 
A 1 258 GLY 258 247 247 GLY GLY A . n 
A 1 259 ARG 259 248 248 ARG ARG A . n 
A 1 260 LEU 260 249 249 LEU LEU A . n 
A 1 261 ASP 261 250 250 ASP ASP A . n 
A 1 262 TYR 262 251 251 TYR TYR A . n 
A 1 263 LEU 263 252 252 LEU LEU A . n 
A 1 264 SER 264 253 253 SER SER A . n 
A 1 265 SER 265 254 254 SER SER A . n 
A 1 266 LEU 266 255 255 LEU LEU A . n 
A 1 267 LYS 267 256 256 LYS LYS A . n 
A 1 268 VAL 268 257 257 VAL VAL A . n 
A 1 269 LYS 269 258 258 LYS LYS A . n 
A 1 270 GLY 270 259 259 GLY GLY A . n 
A 1 271 LEU 271 260 260 LEU LEU A . n 
A 1 272 VAL 272 261 261 VAL VAL A . n 
A 1 273 LEU 273 262 262 LEU LEU A . n 
A 1 274 GLY 274 263 263 GLY GLY A . n 
A 1 275 PRO 275 264 264 PRO PRO A . n 
A 1 276 ILE 276 265 265 ILE ILE A . n 
A 1 277 HIS 277 266 266 HIS HIS A . n 
A 1 278 LYS 278 267 267 LYS LYS A . n 
A 1 279 ASN 279 268 268 ASN ASN A . n 
A 1 280 GLN 280 269 269 GLN GLN A . n 
A 1 281 LYS 281 270 270 LYS LYS A . n 
A 1 282 ASP 282 271 271 ASP ASP A . n 
A 1 283 ASP 283 272 272 ASP ASP A . n 
A 1 284 VAL 284 273 273 VAL VAL A . n 
A 1 285 ALA 285 274 274 ALA ALA A . n 
A 1 286 GLN 286 275 275 GLN GLN A . n 
A 1 287 THR 287 276 276 THR THR A . n 
A 1 288 ASP 288 277 277 ASP ASP A . n 
A 1 289 LEU 289 278 278 LEU LEU A . n 
A 1 290 LEU 290 279 279 LEU LEU A . n 
A 1 291 GLN 291 280 280 GLN GLN A . n 
A 1 292 ILE 292 281 281 ILE ILE A . n 
A 1 293 ASP 293 282 282 ASP ASP A . n 
A 1 294 PRO 294 283 283 PRO PRO A . n 
A 1 295 ASN 295 284 284 ASN ASN A . n 
A 1 296 PHE 296 285 285 PHE PHE A . n 
A 1 297 GLY 297 286 286 GLY GLY A . n 
A 1 298 SER 298 287 287 SER SER A . n 
A 1 299 LYS 299 288 288 LYS LYS A . n 
A 1 300 GLU 300 289 289 GLU GLU A . n 
A 1 301 ASP 301 290 290 ASP ASP A . n 
A 1 302 PHE 302 291 291 PHE PHE A . n 
A 1 303 ASP 303 292 292 ASP ASP A . n 
A 1 304 SER 304 293 293 SER SER A . n 
A 1 305 LEU 305 294 294 LEU LEU A . n 
A 1 306 LEU 306 295 295 LEU LEU A . n 
A 1 307 GLN 307 296 296 GLN GLN A . n 
A 1 308 SER 308 297 297 SER SER A . n 
A 1 309 ALA 309 298 298 ALA ALA A . n 
A 1 310 LYS 310 299 299 LYS LYS A . n 
A 1 311 LYS 311 300 300 LYS LYS A . n 
A 1 312 LYS 312 301 301 LYS LYS A . n 
A 1 313 SER 313 302 302 SER SER A . n 
A 1 314 ILE 314 303 303 ILE ILE A . n 
A 1 315 ARG 315 304 304 ARG ARG A . n 
A 1 316 VAL 316 305 305 VAL VAL A . n 
A 1 317 ILE 317 306 306 ILE ILE A . n 
A 1 318 LEU 318 307 307 LEU LEU A . n 
A 1 319 ASP 319 308 308 ASP ASP A . n 
A 1 320 LEU 320 309 309 LEU LEU A . n 
A 1 321 THR 321 310 310 THR THR A . n 
A 1 322 PRO 322 311 311 PRO PRO A . n 
A 1 323 ASN 323 312 312 ASN ASN A . n 
A 1 324 TYR 324 313 313 TYR TYR A . n 
A 1 325 ARG 325 314 314 ARG ARG A . n 
A 1 326 GLY 326 315 315 GLY GLY A . n 
A 1 327 GLU 327 316 316 GLU GLU A . n 
A 1 328 ASN 328 317 317 ASN ASN A . n 
A 1 329 SER 329 318 318 SER SER A . n 
A 1 330 TRP 330 319 319 TRP TRP A . n 
A 1 331 PHE 331 320 320 PHE PHE A . n 
A 1 332 SER 332 321 321 SER SER A . n 
A 1 333 THR 333 322 322 THR THR A . n 
A 1 334 GLN 334 323 323 GLN GLN A . n 
A 1 335 VAL 335 324 324 VAL VAL A . n 
A 1 336 ASP 336 325 325 ASP ASP A . n 
A 1 337 THR 337 326 326 THR THR A . n 
A 1 338 VAL 338 327 327 VAL VAL A . n 
A 1 339 ALA 339 328 328 ALA ALA A . n 
A 1 340 THR 340 329 329 THR THR A . n 
A 1 341 LYS 341 330 330 LYS LYS A . n 
A 1 342 VAL 342 331 331 VAL VAL A . n 
A 1 343 LYS 343 332 332 LYS LYS A . n 
A 1 344 ASP 344 333 333 ASP ASP A . n 
A 1 345 ALA 345 334 334 ALA ALA A . n 
A 1 346 LEU 346 335 335 LEU LEU A . n 
A 1 347 GLU 347 336 336 GLU GLU A . n 
A 1 348 PHE 348 337 337 PHE PHE A . n 
A 1 349 TRP 349 338 338 TRP TRP A . n 
A 1 350 LEU 350 339 339 LEU LEU A . n 
A 1 351 GLN 351 340 340 GLN GLN A . n 
A 1 352 ALA 352 341 341 ALA ALA A . n 
A 1 353 GLY 353 342 342 GLY GLY A . n 
A 1 354 VAL 354 343 343 VAL VAL A . n 
A 1 355 ASP 355 344 344 ASP ASP A . n 
A 1 356 GLY 356 345 345 GLY GLY A . n 
A 1 357 PHE 357 346 346 PHE PHE A . n 
A 1 358 GLN 358 347 347 GLN GLN A . n 
A 1 359 VAL 359 348 348 VAL VAL A . n 
A 1 360 ARG 360 349 349 ARG ARG A . n 
A 1 361 ASP 361 350 350 ASP ASP A . n 
A 1 362 ILE 362 351 351 ILE ILE A . n 
A 1 363 GLU 363 352 352 GLU GLU A . n 
A 1 364 ASN 364 353 353 ASN ASN A . n 
A 1 365 LEU 365 354 354 LEU LEU A . n 
A 1 366 LYS 366 355 355 LYS LYS A . n 
A 1 367 ASP 367 356 356 ASP ASP A . n 
A 1 368 ALA 368 357 357 ALA ALA A . n 
A 1 369 SER 369 358 358 SER SER A . n 
A 1 370 SER 370 359 359 SER SER A . n 
A 1 371 PHE 371 360 360 PHE PHE A . n 
A 1 372 LEU 372 361 361 LEU LEU A . n 
A 1 373 ALA 373 362 362 ALA ALA A . n 
A 1 374 GLU 374 363 363 GLU GLU A . n 
A 1 375 TRP 375 364 364 TRP TRP A . n 
A 1 376 GLN 376 365 365 GLN GLN A . n 
A 1 377 ASN 377 366 366 ASN ASN A . n 
A 1 378 ILE 378 367 367 ILE ILE A . n 
A 1 379 THR 379 368 368 THR THR A . n 
A 1 380 LYS 380 369 369 LYS LYS A . n 
A 1 381 GLY 381 370 370 GLY GLY A . n 
A 1 382 PHE 382 371 371 PHE PHE A . n 
A 1 383 SER 383 372 372 SER SER A . n 
A 1 384 GLU 384 373 373 GLU GLU A . n 
A 1 385 ASP 385 374 374 ASP ASP A . n 
A 1 386 ARG 386 375 375 ARG ARG A . n 
A 1 387 LEU 387 376 376 LEU LEU A . n 
A 1 388 LEU 388 377 377 LEU LEU A . n 
A 1 389 ILE 389 378 378 ILE ILE A . n 
A 1 390 ALA 390 379 379 ALA ALA A . n 
A 1 391 GLY 391 380 380 GLY GLY A . n 
A 1 392 THR 392 381 381 THR THR A . n 
A 1 393 ASN 393 382 382 ASN ASN A . n 
A 1 394 SER 394 383 383 SER SER A . n 
A 1 395 SER 395 384 384 SER SER A . n 
A 1 396 ASP 396 385 385 ASP ASP A . n 
A 1 397 LEU 397 386 386 LEU LEU A . n 
A 1 398 GLN 398 387 387 GLN GLN A . n 
A 1 399 GLN 399 388 388 GLN GLN A . n 
A 1 400 ILE 400 389 389 ILE ILE A . n 
A 1 401 LEU 401 390 390 LEU LEU A . n 
A 1 402 SER 402 391 391 SER SER A . n 
A 1 403 LEU 403 392 392 LEU LEU A . n 
A 1 404 LEU 404 393 393 LEU LEU A . n 
A 1 405 GLU 405 394 394 GLU GLU A . n 
A 1 406 SER 406 395 395 SER SER A . n 
A 1 407 ASN 407 396 396 ASN ASN A . n 
A 1 408 LYS 408 397 397 LYS LYS A . n 
A 1 409 ASP 409 398 398 ASP ASP A . n 
A 1 410 LEU 410 399 399 LEU LEU A . n 
A 1 411 LEU 411 400 400 LEU LEU A . n 
A 1 412 LEU 412 401 401 LEU LEU A . n 
A 1 413 THR 413 402 402 THR THR A . n 
A 1 414 SER 414 403 403 SER SER A . n 
A 1 415 SER 415 404 404 SER SER A . n 
A 1 416 TYR 416 405 405 TYR TYR A . n 
A 1 417 LEU 417 406 406 LEU LEU A . n 
A 1 418 SER 418 407 407 SER SER A . n 
A 1 419 ASP 419 408 408 ASP ASP A . n 
A 1 420 SER 420 409 409 SER SER A . n 
A 1 421 GLY 421 410 410 GLY GLY A . n 
A 1 422 SER 422 411 411 SER SER A . n 
A 1 423 THR 423 412 412 THR THR A . n 
A 1 424 GLY 424 413 413 GLY GLY A . n 
A 1 425 GLU 425 414 414 GLU GLU A . n 
A 1 426 HIS 426 415 415 HIS HIS A . n 
A 1 427 THR 427 416 416 THR THR A . n 
A 1 428 LYS 428 417 417 LYS LYS A . n 
A 1 429 SER 429 418 418 SER SER A . n 
A 1 430 LEU 430 419 419 LEU LEU A . n 
A 1 431 VAL 431 420 420 VAL VAL A . n 
A 1 432 THR 432 421 421 THR THR A . n 
A 1 433 GLN 433 422 422 GLN GLN A . n 
A 1 434 TYR 434 423 423 TYR TYR A . n 
A 1 435 LEU 435 424 424 LEU LEU A . n 
A 1 436 ASN 436 425 425 ASN ASN A . n 
A 1 437 ALA 437 426 426 ALA ALA A . n 
A 1 438 THR 438 427 427 THR THR A . n 
A 1 439 GLY 439 428 428 GLY GLY A . n 
A 1 440 ASN 440 429 429 ASN ASN A . n 
A 1 441 ARG 441 430 430 ARG ARG A . n 
A 1 442 TRP 442 431 431 TRP TRP A . n 
A 1 443 CYS 443 432 432 CYS CYS A . n 
A 1 444 SER 444 433 433 SER SER A . n 
A 1 445 TRP 445 434 434 TRP TRP A . n 
A 1 446 SER 446 435 435 SER SER A . n 
A 1 447 LEU 447 436 436 LEU LEU A . n 
A 1 448 SER 448 437 437 SER SER A . n 
A 1 449 GLN 449 438 438 GLN GLN A . n 
A 1 450 ALA 450 439 439 ALA ALA A . n 
A 1 451 ARG 451 440 440 ARG ARG A . n 
A 1 452 LEU 452 441 441 LEU LEU A . n 
A 1 453 LEU 453 442 442 LEU LEU A . n 
A 1 454 THR 454 443 443 THR THR A . n 
A 1 455 SER 455 444 444 SER SER A . n 
A 1 456 PHE 456 445 445 PHE PHE A . n 
A 1 457 LEU 457 446 446 LEU LEU A . n 
A 1 458 PRO 458 447 447 PRO PRO A . n 
A 1 459 ALA 459 448 448 ALA ALA A . n 
A 1 460 GLN 460 449 449 GLN GLN A . n 
A 1 461 LEU 461 450 450 LEU LEU A . n 
A 1 462 LEU 462 451 451 LEU LEU A . n 
A 1 463 ARG 463 452 452 ARG ARG A . n 
A 1 464 LEU 464 453 453 LEU LEU A . n 
A 1 465 TYR 465 454 454 TYR TYR A . n 
A 1 466 GLN 466 455 455 GLN GLN A . n 
A 1 467 LEU 467 456 456 LEU LEU A . n 
A 1 468 MET 468 457 457 MET MET A . n 
A 1 469 LEU 469 458 458 LEU LEU A . n 
A 1 470 PHE 470 459 459 PHE PHE A . n 
A 1 471 THR 471 460 460 THR THR A . n 
A 1 472 LEU 472 461 461 LEU LEU A . n 
A 1 473 PRO 473 462 462 PRO PRO A . n 
A 1 474 GLY 474 463 463 GLY GLY A . n 
A 1 475 THR 475 464 464 THR THR A . n 
A 1 476 PRO 476 465 465 PRO PRO A . n 
A 1 477 VAL 477 466 466 VAL VAL A . n 
A 1 478 PHE 478 467 467 PHE PHE A . n 
A 1 479 SER 479 468 468 SER SER A . n 
A 1 480 TYR 480 469 469 TYR TYR A . n 
A 1 481 GLY 481 470 470 GLY GLY A . n 
A 1 482 ASP 482 471 471 ASP ASP A . n 
A 1 483 GLU 483 472 472 GLU GLU A . n 
A 1 484 ILE 484 473 473 ILE ILE A . n 
A 1 485 GLY 485 474 474 GLY GLY A . n 
A 1 486 LEU 486 475 475 LEU LEU A . n 
A 1 487 ASP 487 476 476 ASP ASP A . n 
A 1 488 ALA 488 477 477 ALA ALA A . n 
A 1 489 ALA 489 478 478 ALA ALA A . n 
A 1 490 ALA 490 479 479 ALA ALA A . n 
A 1 491 LEU 491 480 480 LEU LEU A . n 
A 1 492 PRO 492 481 481 PRO PRO A . n 
A 1 493 GLY 493 482 482 GLY GLY A . n 
A 1 494 GLN 494 483 483 GLN GLN A . n 
A 1 495 PRO 495 484 484 PRO PRO A . n 
A 1 496 MET 496 485 485 MET MET A . n 
A 1 497 GLU 497 486 486 GLU GLU A . n 
A 1 498 ALA 498 487 487 ALA ALA A . n 
A 1 499 PRO 499 488 488 PRO PRO A . n 
A 1 500 VAL 500 489 489 VAL VAL A . n 
A 1 501 MET 501 490 490 MET MET A . n 
A 1 502 LEU 502 491 491 LEU LEU A . n 
A 1 503 TRP 503 492 492 TRP TRP A . n 
A 1 504 ASP 504 493 493 ASP ASP A . n 
A 1 505 GLU 505 494 494 GLU GLU A . n 
A 1 506 SER 506 495 495 SER SER A . n 
A 1 507 SER 507 496 496 SER SER A . n 
A 1 508 PHE 508 497 497 PHE PHE A . n 
A 1 509 PRO 509 498 498 PRO PRO A . n 
A 1 510 ASP 510 499 499 ASP ASP A . n 
A 1 511 ILE 511 500 500 ILE ILE A . n 
A 1 512 PRO 512 501 501 PRO PRO A . n 
A 1 513 GLY 513 502 502 GLY GLY A . n 
A 1 514 ALA 514 503 503 ALA ALA A . n 
A 1 515 VAL 515 504 504 VAL VAL A . n 
A 1 516 SER 516 505 505 SER SER A . n 
A 1 517 ALA 517 506 506 ALA ALA A . n 
A 1 518 ASN 518 507 507 ASN ASN A . n 
A 1 519 MET 519 508 508 MET MET A . n 
A 1 520 THR 520 509 509 THR THR A . n 
A 1 521 VAL 521 510 510 VAL VAL A . n 
A 1 522 LYS 522 511 511 LYS LYS A . n 
A 1 523 GLY 523 512 512 GLY GLY A . n 
A 1 524 GLN 524 513 513 GLN GLN A . n 
A 1 525 SER 525 514 514 SER SER A . n 
A 1 526 GLU 526 515 515 GLU GLU A . n 
A 1 527 ASP 527 516 516 ASP ASP A . n 
A 1 528 PRO 528 517 517 PRO PRO A . n 
A 1 529 GLY 529 518 518 GLY GLY A . n 
A 1 530 SER 530 519 519 SER SER A . n 
A 1 531 LEU 531 520 520 LEU LEU A . n 
A 1 532 LEU 532 521 521 LEU LEU A . n 
A 1 533 SER 533 522 522 SER SER A . n 
A 1 534 LEU 534 523 523 LEU LEU A . n 
A 1 535 PHE 535 524 524 PHE PHE A . n 
A 1 536 ARG 536 525 525 ARG ARG A . n 
A 1 537 ARG 537 526 526 ARG ARG A . n 
A 1 538 LEU 538 527 527 LEU LEU A . n 
A 1 539 SER 539 528 528 SER SER A . n 
A 1 540 ASP 540 529 529 ASP ASP A . n 
A 1 541 GLN 541 530 530 GLN GLN A . n 
A 1 542 ARG 542 531 531 ARG ARG A . n 
A 1 543 SER 543 532 532 SER SER A . n 
A 1 544 LYS 544 533 533 LYS LYS A . n 
A 1 545 GLU 545 534 534 GLU GLU A . n 
A 1 546 ARG 546 535 535 ARG ARG A . n 
A 1 547 SER 547 536 536 SER SER A . n 
A 1 548 LEU 548 537 537 LEU LEU A . n 
A 1 549 LEU 549 538 538 LEU LEU A . n 
A 1 550 HIS 550 539 539 HIS HIS A . n 
A 1 551 GLY 551 540 540 GLY GLY A . n 
A 1 552 ASP 552 541 541 ASP ASP A . n 
A 1 553 PHE 553 542 542 PHE PHE A . n 
A 1 554 HIS 554 543 543 HIS HIS A . n 
A 1 555 ALA 555 544 544 ALA ALA A . n 
A 1 556 PHE 556 545 545 PHE PHE A . n 
A 1 557 SER 557 546 546 SER SER A . n 
A 1 558 ALA 558 547 547 ALA ALA A . n 
A 1 559 GLY 559 548 548 GLY GLY A . n 
A 1 560 PRO 560 549 549 PRO PRO A . n 
A 1 561 GLY 561 550 550 GLY GLY A . n 
A 1 562 LEU 562 551 551 LEU LEU A . n 
A 1 563 PHE 563 552 552 PHE PHE A . n 
A 1 564 SER 564 553 553 SER SER A . n 
A 1 565 TYR 565 554 554 TYR TYR A . n 
A 1 566 ILE 566 555 555 ILE ILE A . n 
A 1 567 ARG 567 556 556 ARG ARG A . n 
A 1 568 HIS 568 557 557 HIS HIS A . n 
A 1 569 TRP 569 558 558 TRP TRP A . n 
A 1 570 ASP 570 559 559 ASP ASP A . n 
A 1 571 GLN 571 560 560 GLN GLN A . n 
A 1 572 ASN 572 561 561 ASN ASN A . n 
A 1 573 GLU 573 562 562 GLU GLU A . n 
A 1 574 ARG 574 563 563 ARG ARG A . n 
A 1 575 PHE 575 564 564 PHE PHE A . n 
A 1 576 LEU 576 565 565 LEU LEU A . n 
A 1 577 VAL 577 566 566 VAL VAL A . n 
A 1 578 VAL 578 567 567 VAL VAL A . n 
A 1 579 LEU 579 568 568 LEU LEU A . n 
A 1 580 ASN 580 569 569 ASN ASN A . n 
A 1 581 PHE 581 570 570 PHE PHE A . n 
A 1 582 GLY 582 571 571 GLY GLY A . n 
A 1 583 ASP 583 572 572 ASP ASP A . n 
A 1 584 VAL 584 573 573 VAL VAL A . n 
A 1 585 GLY 585 574 574 GLY GLY A . n 
A 1 586 LEU 586 575 575 LEU LEU A . n 
A 1 587 SER 587 576 576 SER SER A . n 
A 1 588 ALA 588 577 577 ALA ALA A . n 
A 1 589 GLY 589 578 578 GLY GLY A . n 
A 1 590 LEU 590 579 579 LEU LEU A . n 
A 1 591 GLN 591 580 580 GLN GLN A . n 
A 1 592 ALA 592 581 581 ALA ALA A . n 
A 1 593 SER 593 582 582 SER SER A . n 
A 1 594 ASP 594 583 583 ASP ASP A . n 
A 1 595 LEU 595 584 584 LEU LEU A . n 
A 1 596 PRO 596 585 585 PRO PRO A . n 
A 1 597 ALA 597 586 586 ALA ALA A . n 
A 1 598 SER 598 587 587 SER SER A . n 
A 1 599 ALA 599 588 588 ALA ALA A . n 
A 1 600 SER 600 589 589 SER SER A . n 
A 1 601 LEU 601 590 590 LEU LEU A . n 
A 1 602 PRO 602 591 591 PRO PRO A . n 
A 1 603 ALA 603 592 592 ALA ALA A . n 
A 1 604 LYS 604 593 593 LYS LYS A . n 
A 1 605 ALA 605 594 594 ALA ALA A . n 
A 1 606 ASP 606 595 595 ASP ASP A . n 
A 1 607 LEU 607 596 596 LEU LEU A . n 
A 1 608 LEU 608 597 597 LEU LEU A . n 
A 1 609 LEU 609 598 598 LEU LEU A . n 
A 1 610 SER 610 599 599 SER SER A . n 
A 1 611 THR 611 600 600 THR THR A . n 
A 1 612 GLN 612 601 601 GLN GLN A . n 
A 1 613 PRO 613 602 602 PRO PRO A . n 
A 1 614 GLY 614 603 603 GLY GLY A . n 
A 1 615 ARG 615 604 604 ARG ARG A . n 
A 1 616 GLU 616 605 605 GLU GLU A . n 
A 1 617 GLU 617 606 606 GLU GLU A . n 
A 1 618 GLY 618 607 607 GLY GLY A . n 
A 1 619 SER 619 608 608 SER SER A . n 
A 1 620 PRO 620 609 609 PRO PRO A . n 
A 1 621 LEU 621 610 610 LEU LEU A . n 
A 1 622 GLU 622 611 611 GLU GLU A . n 
A 1 623 LEU 623 612 612 LEU LEU A . n 
A 1 624 GLU 624 613 613 GLU GLU A . n 
A 1 625 ARG 625 614 614 ARG ARG A . n 
A 1 626 LEU 626 615 615 LEU LEU A . n 
A 1 627 LYS 627 616 616 LYS LYS A . n 
A 1 628 LEU 628 617 617 LEU LEU A . n 
A 1 629 GLU 629 618 618 GLU GLU A . n 
A 1 630 PRO 630 619 619 PRO PRO A . n 
A 1 631 HIS 631 620 620 HIS HIS A . n 
A 1 632 GLU 632 621 621 GLU GLU A . n 
A 1 633 GLY 633 622 622 GLY GLY A . n 
A 1 634 LEU 634 623 623 LEU LEU A . n 
A 1 635 LEU 635 624 624 LEU LEU A . n 
A 1 636 LEU 636 625 625 LEU LEU A . n 
A 1 637 ARG 637 626 626 ARG ARG A . n 
A 1 638 PHE 638 627 627 PHE PHE A . n 
A 1 639 PRO 639 628 628 PRO PRO A . n 
A 1 640 TYR 640 629 629 TYR TYR A . n 
A 1 641 ALA 641 630 630 ALA ALA A . n 
A 1 642 ALA 642 631 631 ALA ALA A . n 
A 1 643 THR 643 632 ?   ?   ?   A . n 
A 1 644 GLY 644 633 ?   ?   ?   A . n 
A 1 645 ALA 645 634 ?   ?   ?   A . n 
B 2 1   ASP 1   -17 ?   ?   ?   B . n 
B 2 2   TYR 2   -16 ?   ?   ?   B . n 
B 2 3   LYS 3   -15 ?   ?   ?   B . n 
B 2 4   ASP 4   -14 ?   ?   ?   B . n 
B 2 5   ASP 5   -13 ?   ?   ?   B . n 
B 2 6   ASP 6   -12 ?   ?   ?   B . n 
B 2 7   ASP 7   -11 ?   ?   ?   B . n 
B 2 8   LYS 8   -10 ?   ?   ?   B . n 
B 2 9   SER 9   -9  ?   ?   ?   B . n 
B 2 10  GLY 10  -8  ?   ?   ?   B . n 
B 2 11  PRO 11  -7  ?   ?   ?   B . n 
B 2 12  ASP 12  -6  ?   ?   ?   B . n 
B 2 13  GLU 13  -5  ?   ?   ?   B . n 
B 2 14  VAL 14  -4  ?   ?   ?   B . n 
B 2 15  ASP 15  -3  ?   ?   ?   B . n 
B 2 16  ALA 16  -2  ?   ?   ?   B . n 
B 2 17  SER 17  -1  ?   ?   ?   B . n 
B 2 18  GLY 18  0   ?   ?   ?   B . n 
B 2 19  ARG 19  1   ?   ?   ?   B . n 
B 2 20  VAL 20  2   ?   ?   ?   B . n 
B 2 21  ASP 21  3   ?   ?   ?   B . n 
B 2 22  SER 22  4   ?   ?   ?   B . n 
B 2 23  THR 23  5   ?   ?   ?   B . n 
B 2 24  GLU 24  6   ?   ?   ?   B . n 
B 2 25  TYR 25  7   ?   ?   ?   B . n 
B 2 26  GLU 26  8   ?   ?   ?   B . n 
B 2 27  VAL 27  9   ?   ?   ?   B . n 
B 2 28  ALA 28  10  ?   ?   ?   B . n 
B 2 29  SER 29  11  ?   ?   ?   B . n 
B 2 30  GLN 30  12  ?   ?   ?   B . n 
B 2 31  PRO 31  13  ?   ?   ?   B . n 
B 2 32  GLU 32  14  ?   ?   ?   B . n 
B 2 33  VAL 33  15  ?   ?   ?   B . n 
B 2 34  GLU 34  16  ?   ?   ?   B . n 
B 2 35  THR 35  17  ?   ?   ?   B . n 
B 2 36  SER 36  18  ?   ?   ?   B . n 
B 2 37  PRO 37  19  ?   ?   ?   B . n 
B 2 38  LEU 38  20  ?   ?   ?   B . n 
B 2 39  GLY 39  21  ?   ?   ?   B . n 
B 2 40  ASP 40  22  ?   ?   ?   B . n 
B 2 41  GLY 41  23  ?   ?   ?   B . n 
B 2 42  ALA 42  24  ?   ?   ?   B . n 
B 2 43  SER 43  25  ?   ?   ?   B . n 
B 2 44  PRO 44  26  ?   ?   ?   B . n 
B 2 45  GLY 45  27  ?   ?   ?   B . n 
B 2 46  PRO 46  28  ?   ?   ?   B . n 
B 2 47  GLU 47  29  ?   ?   ?   B . n 
B 2 48  GLN 48  30  30  GLN GLN B . n 
B 2 49  VAL 49  31  31  VAL VAL B . n 
B 2 50  LYS 50  32  32  LYS LYS B . n 
B 2 51  LEU 51  33  33  LEU LEU B . n 
B 2 52  LYS 52  34  34  LYS LYS B . n 
B 2 53  LYS 53  35  35  LYS LYS B . n 
B 2 54  GLU 54  36  36  GLU GLU B . n 
B 2 55  ILE 55  37  37  ILE ILE B . n 
B 2 56  SER 56  38  38  SER SER B . n 
B 2 57  LEU 57  39  39  LEU LEU B . n 
B 2 58  LEU 58  40  40  LEU LEU B . n 
B 2 59  ASN 59  41  41  ASN ASN B . n 
B 2 60  GLY 60  42  42  GLY GLY B . n 
B 2 61  VAL 61  43  43  VAL VAL B . n 
B 2 62  CYS 62  44  44  CYS CYS B . n 
B 2 63  LEU 63  45  45  LEU LEU B . n 
B 2 64  ILE 64  46  46  ILE ILE B . n 
B 2 65  VAL 65  47  47  VAL VAL B . n 
B 2 66  GLY 66  48  48  GLY GLY B . n 
B 2 67  ASN 67  49  49  ASN ASN B . n 
B 2 68  MET 68  50  50  MET MET B . n 
B 2 69  ILE 69  51  51  ILE ILE B . n 
B 2 70  GLY 70  52  52  GLY GLY B . n 
B 2 71  SER 71  53  53  SER SER B . n 
B 2 72  GLY 72  54  54  GLY GLY B . n 
B 2 73  ILE 73  55  55  ILE ILE B . n 
B 2 74  PHE 74  56  56  PHE PHE B . n 
B 2 75  VAL 75  57  57  VAL VAL B . n 
B 2 76  SER 76  58  58  SER SER B . n 
B 2 77  PRO 77  59  59  PRO PRO B . n 
B 2 78  LYS 78  60  60  LYS LYS B . n 
B 2 79  GLY 79  61  61  GLY GLY B . n 
B 2 80  VAL 80  62  62  VAL VAL B . n 
B 2 81  LEU 81  63  63  LEU LEU B . n 
B 2 82  ILE 82  64  64  ILE ILE B . n 
B 2 83  TYR 83  65  65  TYR TYR B . n 
B 2 84  SER 84  66  66  SER SER B . n 
B 2 85  ALA 85  67  67  ALA ALA B . n 
B 2 86  SER 86  68  68  SER SER B . n 
B 2 87  PHE 87  69  69  PHE PHE B . n 
B 2 88  GLY 88  70  70  GLY GLY B . n 
B 2 89  LEU 89  71  71  LEU LEU B . n 
B 2 90  SER 90  72  72  SER SER B . n 
B 2 91  LEU 91  73  73  LEU LEU B . n 
B 2 92  VAL 92  74  74  VAL VAL B . n 
B 2 93  ILE 93  75  75  ILE ILE B . n 
B 2 94  TRP 94  76  76  TRP TRP B . n 
B 2 95  ALA 95  77  77  ALA ALA B . n 
B 2 96  VAL 96  78  78  VAL VAL B . n 
B 2 97  GLY 97  79  79  GLY GLY B . n 
B 2 98  GLY 98  80  80  GLY GLY B . n 
B 2 99  LEU 99  81  81  LEU LEU B . n 
B 2 100 PHE 100 82  82  PHE PHE B . n 
B 2 101 SER 101 83  83  SER SER B . n 
B 2 102 VAL 102 84  84  VAL VAL B . n 
B 2 103 PHE 103 85  85  PHE PHE B . n 
B 2 104 GLY 104 86  86  GLY GLY B . n 
B 2 105 ALA 105 87  87  ALA ALA B . n 
B 2 106 LEU 106 88  88  LEU LEU B . n 
B 2 107 CYS 107 89  89  CYS CYS B . n 
B 2 108 TYR 108 90  90  TYR TYR B . n 
B 2 109 ALA 109 91  91  ALA ALA B . n 
B 2 110 GLU 110 92  92  GLU GLU B . n 
B 2 111 LEU 111 93  93  LEU LEU B . n 
B 2 112 GLY 112 94  94  GLY GLY B . n 
B 2 113 THR 113 95  95  THR THR B . n 
B 2 114 THR 114 96  96  THR THR B . n 
B 2 115 ILE 115 97  97  ILE ILE B . n 
B 2 116 LYS 116 98  98  LYS LYS B . n 
B 2 117 LYS 117 99  99  LYS LYS B . n 
B 2 118 SER 118 100 100 SER SER B . n 
B 2 119 GLY 119 101 101 GLY GLY B . n 
B 2 120 ALA 120 102 102 ALA ALA B . n 
B 2 121 SER 121 103 103 SER SER B . n 
B 2 122 TYR 122 104 104 TYR TYR B . n 
B 2 123 ALA 123 105 105 ALA ALA B . n 
B 2 124 TYR 124 106 106 TYR TYR B . n 
B 2 125 ILE 125 107 107 ILE ILE B . n 
B 2 126 LEU 126 108 108 LEU LEU B . n 
B 2 127 GLU 127 109 109 GLU GLU B . n 
B 2 128 ALA 128 110 110 ALA ALA B . n 
B 2 129 PHE 129 111 111 PHE PHE B . n 
B 2 130 GLY 130 112 112 GLY GLY B . n 
B 2 131 GLY 131 113 113 GLY GLY B . n 
B 2 132 PHE 132 114 114 PHE PHE B . n 
B 2 133 LEU 133 115 115 LEU LEU B . n 
B 2 134 ALA 134 116 116 ALA ALA B . n 
B 2 135 PHE 135 117 117 PHE PHE B . n 
B 2 136 ILE 136 118 118 ILE ILE B . n 
B 2 137 ARG 137 119 119 ARG ARG B . n 
B 2 138 LEU 138 120 120 LEU LEU B . n 
B 2 139 TRP 139 121 121 TRP TRP B . n 
B 2 140 THR 140 122 122 THR THR B . n 
B 2 141 SER 141 123 123 SER SER B . n 
B 2 142 LEU 142 124 124 LEU LEU B . n 
B 2 143 LEU 143 125 125 LEU LEU B . n 
B 2 144 ILE 144 126 126 ILE ILE B . n 
B 2 145 ILE 145 127 127 ILE ILE B . n 
B 2 146 GLU 146 128 128 GLU GLU B . n 
B 2 147 PRO 147 129 129 PRO PRO B . n 
B 2 148 THR 148 130 130 THR THR B . n 
B 2 149 SER 149 131 131 SER SER B . n 
B 2 150 GLN 150 132 132 GLN GLN B . n 
B 2 151 ALA 151 133 133 ALA ALA B . n 
B 2 152 ILE 152 134 134 ILE ILE B . n 
B 2 153 ILE 153 135 135 ILE ILE B . n 
B 2 154 ALA 154 136 136 ALA ALA B . n 
B 2 155 ILE 155 137 137 ILE ILE B . n 
B 2 156 THR 156 138 138 THR THR B . n 
B 2 157 PHE 157 139 139 PHE PHE B . n 
B 2 158 ALA 158 140 140 ALA ALA B . n 
B 2 159 ASN 159 141 141 ASN ASN B . n 
B 2 160 TYR 160 142 142 TYR TYR B . n 
B 2 161 MET 161 143 143 MET MET B . n 
B 2 162 VAL 162 144 144 VAL VAL B . n 
B 2 163 GLN 163 145 145 GLN GLN B . n 
B 2 164 PRO 164 146 146 PRO PRO B . n 
B 2 165 LEU 165 147 147 LEU LEU B . n 
B 2 166 PHE 166 148 148 PHE PHE B . n 
B 2 167 PRO 167 149 149 PRO PRO B . n 
B 2 168 SER 168 150 150 SER SER B . n 
B 2 169 CYS 169 151 151 CYS CYS B . n 
B 2 170 PHE 170 152 152 PHE PHE B . n 
B 2 171 ALA 171 153 153 ALA ALA B . n 
B 2 172 PRO 172 154 154 PRO PRO B . n 
B 2 173 TYR 173 155 155 TYR TYR B . n 
B 2 174 ALA 174 156 156 ALA ALA B . n 
B 2 175 ALA 175 157 157 ALA ALA B . n 
B 2 176 SER 176 158 158 SER SER B . n 
B 2 177 ARG 177 159 159 ARG ARG B . n 
B 2 178 LEU 178 160 160 LEU LEU B . n 
B 2 179 LEU 179 161 161 LEU LEU B . n 
B 2 180 ALA 180 162 162 ALA ALA B . n 
B 2 181 ALA 181 163 163 ALA ALA B . n 
B 2 182 ALA 182 164 164 ALA ALA B . n 
B 2 183 CYS 183 165 165 CYS CYS B . n 
B 2 184 ILE 184 166 166 ILE ILE B . n 
B 2 185 CYS 185 167 167 CYS CYS B . n 
B 2 186 LEU 186 168 168 LEU LEU B . n 
B 2 187 LEU 187 169 169 LEU LEU B . n 
B 2 188 THR 188 170 170 THR THR B . n 
B 2 189 PHE 189 171 171 PHE PHE B . n 
B 2 190 ILE 190 172 172 ILE ILE B . n 
B 2 191 ASN 191 173 173 ASN ASN B . n 
B 2 192 CYS 192 174 174 CYS CYS B . n 
B 2 193 ALA 193 175 175 ALA ALA B . n 
B 2 194 TYR 194 176 176 TYR TYR B . n 
B 2 195 VAL 195 177 177 VAL VAL B . n 
B 2 196 LYS 196 178 178 LYS LYS B . n 
B 2 197 TRP 197 179 179 TRP TRP B . n 
B 2 198 GLY 198 180 180 GLY GLY B . n 
B 2 199 THR 199 181 181 THR THR B . n 
B 2 200 LEU 200 182 182 LEU LEU B . n 
B 2 201 VAL 201 183 183 VAL VAL B . n 
B 2 202 GLN 202 184 184 GLN GLN B . n 
B 2 203 ASP 203 185 185 ASP ASP B . n 
B 2 204 ILE 204 186 186 ILE ILE B . n 
B 2 205 PHE 205 187 187 PHE PHE B . n 
B 2 206 THR 206 188 188 THR THR B . n 
B 2 207 TYR 207 189 189 TYR TYR B . n 
B 2 208 ALA 208 190 190 ALA ALA B . n 
B 2 209 LYS 209 191 191 LYS LYS B . n 
B 2 210 VAL 210 192 192 VAL VAL B . n 
B 2 211 LEU 211 193 193 LEU LEU B . n 
B 2 212 ALA 212 194 194 ALA ALA B . n 
B 2 213 LEU 213 195 195 LEU LEU B . n 
B 2 214 ILE 214 196 196 ILE ILE B . n 
B 2 215 ALA 215 197 197 ALA ALA B . n 
B 2 216 VAL 216 198 198 VAL VAL B . n 
B 2 217 ILE 217 199 199 ILE ILE B . n 
B 2 218 VAL 218 200 200 VAL VAL B . n 
B 2 219 ALA 219 201 201 ALA ALA B . n 
B 2 220 GLY 220 202 202 GLY GLY B . n 
B 2 221 ILE 221 203 203 ILE ILE B . n 
B 2 222 VAL 222 204 204 VAL VAL B . n 
B 2 223 ARG 223 205 205 ARG ARG B . n 
B 2 224 LEU 224 206 206 LEU LEU B . n 
B 2 225 GLY 225 207 207 GLY GLY B . n 
B 2 226 GLN 226 208 208 GLN GLN B . n 
B 2 227 GLY 227 209 209 GLY GLY B . n 
B 2 228 ALA 228 210 210 ALA ALA B . n 
B 2 229 SER 229 211 211 SER SER B . n 
B 2 230 THR 230 212 212 THR THR B . n 
B 2 231 HIS 231 213 213 HIS HIS B . n 
B 2 232 PHE 232 214 214 PHE PHE B . n 
B 2 233 GLU 233 215 215 GLU GLU B . n 
B 2 234 ASN 234 216 216 ASN ASN B . n 
B 2 235 SER 235 217 217 SER SER B . n 
B 2 236 PHE 236 218 218 PHE PHE B . n 
B 2 237 GLU 237 219 219 GLU GLU B . n 
B 2 238 GLY 238 220 220 GLY GLY B . n 
B 2 239 SER 239 221 221 SER SER B . n 
B 2 240 SER 240 222 222 SER SER B . n 
B 2 241 PHE 241 223 223 PHE PHE B . n 
B 2 242 ALA 242 224 224 ALA ALA B . n 
B 2 243 VAL 243 225 225 VAL VAL B . n 
B 2 244 GLY 244 226 226 GLY GLY B . n 
B 2 245 ASP 245 227 227 ASP ASP B . n 
B 2 246 ILE 246 228 228 ILE ILE B . n 
B 2 247 ALA 247 229 229 ALA ALA B . n 
B 2 248 LEU 248 230 230 LEU LEU B . n 
B 2 249 ALA 249 231 231 ALA ALA B . n 
B 2 250 LEU 250 232 232 LEU LEU B . n 
B 2 251 TYR 251 233 233 TYR TYR B . n 
B 2 252 SER 252 234 234 SER SER B . n 
B 2 253 ALA 253 235 235 ALA ALA B . n 
B 2 254 LEU 254 236 236 LEU LEU B . n 
B 2 255 PHE 255 237 237 PHE PHE B . n 
B 2 256 SER 256 238 238 SER SER B . n 
B 2 257 TYR 257 239 239 TYR TYR B . n 
B 2 258 SER 258 240 240 SER SER B . n 
B 2 259 GLY 259 241 241 GLY GLY B . n 
B 2 260 TRP 260 242 242 TRP TRP B . n 
B 2 261 ASP 261 243 243 ASP ASP B . n 
B 2 262 THR 262 244 244 THR THR B . n 
B 2 263 LEU 263 245 245 LEU LEU B . n 
B 2 264 ASN 264 246 246 ASN ASN B . n 
B 2 265 TYR 265 247 247 TYR TYR B . n 
B 2 266 VAL 266 248 248 VAL VAL B . n 
B 2 267 THR 267 249 249 THR THR B . n 
B 2 268 GLU 268 250 250 GLU GLU B . n 
B 2 269 GLU 269 251 251 GLU GLU B . n 
B 2 270 ILE 270 252 252 ILE ILE B . n 
B 2 271 LYS 271 253 253 LYS LYS B . n 
B 2 272 ASN 272 254 254 ASN ASN B . n 
B 2 273 PRO 273 255 255 PRO PRO B . n 
B 2 274 GLU 274 256 256 GLU GLU B . n 
B 2 275 ARG 275 257 257 ARG ARG B . n 
B 2 276 ASN 276 258 258 ASN ASN B . n 
B 2 277 LEU 277 259 259 LEU LEU B . n 
B 2 278 PRO 278 260 260 PRO PRO B . n 
B 2 279 LEU 279 261 261 LEU LEU B . n 
B 2 280 SER 280 262 262 SER SER B . n 
B 2 281 ILE 281 263 263 ILE ILE B . n 
B 2 282 GLY 282 264 264 GLY GLY B . n 
B 2 283 ILE 283 265 265 ILE ILE B . n 
B 2 284 SER 284 266 266 SER SER B . n 
B 2 285 MET 285 267 267 MET MET B . n 
B 2 286 PRO 286 268 268 PRO PRO B . n 
B 2 287 ILE 287 269 269 ILE ILE B . n 
B 2 288 VAL 288 270 270 VAL VAL B . n 
B 2 289 THR 289 271 271 THR THR B . n 
B 2 290 ILE 290 272 272 ILE ILE B . n 
B 2 291 ILE 291 273 273 ILE ILE B . n 
B 2 292 TYR 292 274 274 TYR TYR B . n 
B 2 293 ILE 293 275 275 ILE ILE B . n 
B 2 294 LEU 294 276 276 LEU LEU B . n 
B 2 295 THR 295 277 277 THR THR B . n 
B 2 296 ASN 296 278 278 ASN ASN B . n 
B 2 297 VAL 297 279 279 VAL VAL B . n 
B 2 298 ALA 298 280 280 ALA ALA B . n 
B 2 299 TYR 299 281 281 TYR TYR B . n 
B 2 300 TYR 300 282 282 TYR TYR B . n 
B 2 301 THR 301 283 283 THR THR B . n 
B 2 302 VAL 302 284 284 VAL VAL B . n 
B 2 303 LEU 303 285 285 LEU LEU B . n 
B 2 304 ASP 304 286 286 ASP ASP B . n 
B 2 305 MET 305 287 287 MET MET B . n 
B 2 306 ARG 306 288 288 ARG ARG B . n 
B 2 307 ASP 307 289 289 ASP ASP B . n 
B 2 308 ILE 308 290 290 ILE ILE B . n 
B 2 309 LEU 309 291 291 LEU LEU B . n 
B 2 310 ALA 310 292 292 ALA ALA B . n 
B 2 311 SER 311 293 293 SER SER B . n 
B 2 312 ASP 312 294 294 ASP ASP B . n 
B 2 313 ALA 313 295 295 ALA ALA B . n 
B 2 314 VAL 314 296 296 VAL VAL B . n 
B 2 315 ALA 315 297 297 ALA ALA B . n 
B 2 316 VAL 316 298 298 VAL VAL B . n 
B 2 317 THR 317 299 299 THR THR B . n 
B 2 318 PHE 318 300 300 PHE PHE B . n 
B 2 319 ALA 319 301 301 ALA ALA B . n 
B 2 320 ASP 320 302 302 ASP ASP B . n 
B 2 321 GLN 321 303 303 GLN GLN B . n 
B 2 322 ILE 322 304 304 ILE ILE B . n 
B 2 323 PHE 323 305 305 PHE PHE B . n 
B 2 324 GLY 324 306 306 GLY GLY B . n 
B 2 325 ILE 325 307 307 ILE ILE B . n 
B 2 326 PHE 326 308 308 PHE PHE B . n 
B 2 327 ASN 327 309 309 ASN ASN B . n 
B 2 328 TRP 328 310 310 TRP TRP B . n 
B 2 329 ILE 329 311 311 ILE ILE B . n 
B 2 330 ILE 330 312 312 ILE ILE B . n 
B 2 331 PRO 331 313 313 PRO PRO B . n 
B 2 332 LEU 332 314 314 LEU LEU B . n 
B 2 333 SER 333 315 315 SER SER B . n 
B 2 334 VAL 334 316 316 VAL VAL B . n 
B 2 335 ALA 335 317 317 ALA ALA B . n 
B 2 336 LEU 336 318 318 LEU LEU B . n 
B 2 337 SER 337 319 319 SER SER B . n 
B 2 338 CYS 338 320 320 CYS CYS B . n 
B 2 339 PHE 339 321 321 PHE PHE B . n 
B 2 340 GLY 340 322 322 GLY GLY B . n 
B 2 341 GLY 341 323 323 GLY GLY B . n 
B 2 342 LEU 342 324 324 LEU LEU B . n 
B 2 343 ASN 343 325 325 ASN ASN B . n 
B 2 344 ALA 344 326 326 ALA ALA B . n 
B 2 345 SER 345 327 327 SER SER B . n 
B 2 346 ILE 346 328 328 ILE ILE B . n 
B 2 347 VAL 347 329 329 VAL VAL B . n 
B 2 348 ALA 348 330 330 ALA ALA B . n 
B 2 349 ALA 349 331 331 ALA ALA B . n 
B 2 350 SER 350 332 332 SER SER B . n 
B 2 351 ARG 351 333 333 ARG ARG B . n 
B 2 352 LEU 352 334 334 LEU LEU B . n 
B 2 353 PHE 353 335 335 PHE PHE B . n 
B 2 354 PHE 354 336 336 PHE PHE B . n 
B 2 355 VAL 355 337 337 VAL VAL B . n 
B 2 356 GLY 356 338 338 GLY GLY B . n 
B 2 357 SER 357 339 339 SER SER B . n 
B 2 358 ARG 358 340 340 ARG ARG B . n 
B 2 359 GLU 359 341 341 GLU GLU B . n 
B 2 360 GLY 360 342 342 GLY GLY B . n 
B 2 361 HIS 361 343 343 HIS HIS B . n 
B 2 362 LEU 362 344 344 LEU LEU B . n 
B 2 363 PRO 363 345 345 PRO PRO B . n 
B 2 364 ASP 364 346 346 ASP ASP B . n 
B 2 365 ALA 365 347 347 ALA ALA B . n 
B 2 366 ILE 366 348 348 ILE ILE B . n 
B 2 367 CYS 367 349 349 CYS CYS B . n 
B 2 368 MET 368 350 350 MET MET B . n 
B 2 369 ILE 369 351 351 ILE ILE B . n 
B 2 370 HIS 370 352 352 HIS HIS B . n 
B 2 371 VAL 371 353 353 VAL VAL B . n 
B 2 372 GLU 372 354 354 GLU GLU B . n 
B 2 373 ARG 373 355 355 ARG ARG B . n 
B 2 374 PHE 374 356 356 PHE PHE B . n 
B 2 375 THR 375 357 357 THR THR B . n 
B 2 376 PRO 376 358 358 PRO PRO B . n 
B 2 377 VAL 377 359 359 VAL VAL B . n 
B 2 378 PRO 378 360 360 PRO PRO B . n 
B 2 379 SER 379 361 361 SER SER B . n 
B 2 380 LEU 380 362 362 LEU LEU B . n 
B 2 381 LEU 381 363 363 LEU LEU B . n 
B 2 382 PHE 382 364 364 PHE PHE B . n 
B 2 383 ASN 383 365 365 ASN ASN B . n 
B 2 384 GLY 384 366 366 GLY GLY B . n 
B 2 385 ILE 385 367 367 ILE ILE B . n 
B 2 386 MET 386 368 368 MET MET B . n 
B 2 387 ALA 387 369 369 ALA ALA B . n 
B 2 388 LEU 388 370 370 LEU LEU B . n 
B 2 389 ILE 389 371 371 ILE ILE B . n 
B 2 390 TYR 390 372 372 TYR TYR B . n 
B 2 391 LEU 391 373 373 LEU LEU B . n 
B 2 392 CYS 392 374 374 CYS CYS B . n 
B 2 393 VAL 393 375 375 VAL VAL B . n 
B 2 394 GLU 394 376 376 GLU GLU B . n 
B 2 395 ASP 395 377 377 ASP ASP B . n 
B 2 396 ILE 396 378 378 ILE ILE B . n 
B 2 397 PHE 397 379 379 PHE PHE B . n 
B 2 398 GLN 398 380 380 GLN GLN B . n 
B 2 399 LEU 399 381 381 LEU LEU B . n 
B 2 400 ILE 400 382 382 ILE ILE B . n 
B 2 401 ASN 401 383 383 ASN ASN B . n 
B 2 402 TYR 402 384 384 TYR TYR B . n 
B 2 403 TYR 403 385 385 TYR TYR B . n 
B 2 404 SER 404 386 386 SER SER B . n 
B 2 405 PHE 405 387 387 PHE PHE B . n 
B 2 406 SER 406 388 388 SER SER B . n 
B 2 407 TYR 407 389 389 TYR TYR B . n 
B 2 408 TRP 408 390 390 TRP TRP B . n 
B 2 409 PHE 409 391 391 PHE PHE B . n 
B 2 410 PHE 410 392 392 PHE PHE B . n 
B 2 411 VAL 411 393 393 VAL VAL B . n 
B 2 412 GLY 412 394 394 GLY GLY B . n 
B 2 413 LEU 413 395 395 LEU LEU B . n 
B 2 414 SER 414 396 396 SER SER B . n 
B 2 415 ILE 415 397 397 ILE ILE B . n 
B 2 416 VAL 416 398 398 VAL VAL B . n 
B 2 417 GLY 417 399 399 GLY GLY B . n 
B 2 418 GLN 418 400 400 GLN GLN B . n 
B 2 419 LEU 419 401 401 LEU LEU B . n 
B 2 420 TYR 420 402 402 TYR TYR B . n 
B 2 421 LEU 421 403 403 LEU LEU B . n 
B 2 422 ARG 422 404 404 ARG ARG B . n 
B 2 423 TRP 423 405 405 TRP TRP B . n 
B 2 424 LYS 424 406 406 LYS LYS B . n 
B 2 425 GLU 425 407 407 GLU GLU B . n 
B 2 426 PRO 426 408 408 PRO PRO B . n 
B 2 427 ASP 427 409 409 ASP ASP B . n 
B 2 428 ARG 428 410 410 ARG ARG B . n 
B 2 429 PRO 429 411 411 PRO PRO B . n 
B 2 430 ARG 430 412 412 ARG ARG B . n 
B 2 431 PRO 431 413 413 PRO PRO B . n 
B 2 432 LEU 432 414 414 LEU LEU B . n 
B 2 433 LYS 433 415 415 LYS LYS B . n 
B 2 434 LEU 434 416 416 LEU LEU B . n 
B 2 435 SER 435 417 417 SER SER B . n 
B 2 436 VAL 436 418 418 VAL VAL B . n 
B 2 437 PHE 437 419 419 PHE PHE B . n 
B 2 438 PHE 438 420 420 PHE PHE B . n 
B 2 439 PRO 439 421 421 PRO PRO B . n 
B 2 440 ILE 440 422 422 ILE ILE B . n 
B 2 441 VAL 441 423 423 VAL VAL B . n 
B 2 442 PHE 442 424 424 PHE PHE B . n 
B 2 443 CYS 443 425 425 CYS CYS B . n 
B 2 444 LEU 444 426 426 LEU LEU B . n 
B 2 445 CYS 445 427 427 CYS CYS B . n 
B 2 446 THR 446 428 428 THR THR B . n 
B 2 447 ILE 447 429 429 ILE ILE B . n 
B 2 448 PHE 448 430 430 PHE PHE B . n 
B 2 449 LEU 449 431 431 LEU LEU B . n 
B 2 450 VAL 450 432 432 VAL VAL B . n 
B 2 451 ALA 451 433 433 ALA ALA B . n 
B 2 452 VAL 452 434 434 VAL VAL B . n 
B 2 453 PRO 453 435 435 PRO PRO B . n 
B 2 454 LEU 454 436 436 LEU LEU B . n 
B 2 455 TYR 455 437 437 TYR TYR B . n 
B 2 456 SER 456 438 438 SER SER B . n 
B 2 457 ASP 457 439 439 ASP ASP B . n 
B 2 458 THR 458 440 440 THR THR B . n 
B 2 459 ILE 459 441 441 ILE ILE B . n 
B 2 460 ASN 460 442 442 ASN ASN B . n 
B 2 461 SER 461 443 443 SER SER B . n 
B 2 462 LEU 462 444 444 LEU LEU B . n 
B 2 463 ILE 463 445 445 ILE ILE B . n 
B 2 464 GLY 464 446 446 GLY GLY B . n 
B 2 465 ILE 465 447 447 ILE ILE B . n 
B 2 466 ALA 466 448 448 ALA ALA B . n 
B 2 467 ILE 467 449 449 ILE ILE B . n 
B 2 468 ALA 468 450 450 ALA ALA B . n 
B 2 469 LEU 469 451 451 LEU LEU B . n 
B 2 470 SER 470 452 452 SER SER B . n 
B 2 471 GLY 471 453 453 GLY GLY B . n 
B 2 472 LEU 472 454 454 LEU LEU B . n 
B 2 473 PRO 473 455 455 PRO PRO B . n 
B 2 474 PHE 474 456 456 PHE PHE B . n 
B 2 475 TYR 475 457 457 TYR TYR B . n 
B 2 476 PHE 476 458 458 PHE PHE B . n 
B 2 477 LEU 477 459 459 LEU LEU B . n 
B 2 478 ILE 478 460 460 ILE ILE B . n 
B 2 479 ILE 479 461 461 ILE ILE B . n 
B 2 480 ARG 480 462 462 ARG ARG B . n 
B 2 481 VAL 481 463 463 VAL VAL B . n 
B 2 482 PRO 482 464 464 PRO PRO B . n 
B 2 483 GLU 483 465 465 GLU GLU B . n 
B 2 484 HIS 484 466 466 HIS HIS B . n 
B 2 485 LYS 485 467 467 LYS LYS B . n 
B 2 486 ARG 486 468 468 ARG ARG B . n 
B 2 487 PRO 487 469 469 PRO PRO B . n 
B 2 488 LEU 488 470 470 LEU LEU B . n 
B 2 489 TYR 489 471 471 TYR TYR B . n 
B 2 490 LEU 490 472 472 LEU LEU B . n 
B 2 491 ARG 491 473 473 ARG ARG B . n 
B 2 492 ARG 492 474 474 ARG ARG B . n 
B 2 493 ILE 493 475 475 ILE ILE B . n 
B 2 494 VAL 494 476 476 VAL VAL B . n 
B 2 495 GLY 495 477 477 GLY GLY B . n 
B 2 496 SER 496 478 478 SER SER B . n 
B 2 497 ALA 497 479 479 ALA ALA B . n 
B 2 498 THR 498 480 480 THR THR B . n 
B 2 499 ARG 499 481 481 ARG ARG B . n 
B 2 500 TYR 500 482 482 TYR TYR B . n 
B 2 501 LEU 501 483 483 LEU LEU B . n 
B 2 502 GLN 502 484 484 GLN GLN B . n 
B 2 503 VAL 503 485 485 VAL VAL B . n 
B 2 504 LEU 504 486 486 LEU LEU B . n 
B 2 505 CYS 505 487 487 CYS CYS B . n 
B 2 506 MET 506 488 488 MET MET B . n 
B 2 507 SER 507 489 489 SER SER B . n 
B 2 508 VAL 508 490 490 VAL VAL B . n 
B 2 509 ALA 509 491 491 ALA ALA B . n 
B 2 510 ALA 510 492 492 ALA ALA B . n 
B 2 511 GLU 511 493 493 GLU GLU B . n 
B 2 512 MET 512 494 ?   ?   ?   B . n 
B 2 513 ASP 513 495 ?   ?   ?   B . n 
B 2 514 LEU 514 496 ?   ?   ?   B . n 
B 2 515 GLU 515 497 ?   ?   ?   B . n 
B 2 516 ASP 516 498 ?   ?   ?   B . n 
B 2 517 GLY 517 499 ?   ?   ?   B . n 
B 2 518 GLY 518 500 ?   ?   ?   B . n 
B 2 519 GLU 519 501 ?   ?   ?   B . n 
B 2 520 MET 520 502 ?   ?   ?   B . n 
B 2 521 PRO 521 503 ?   ?   ?   B . n 
B 2 522 LYS 522 504 ?   ?   ?   B . n 
B 2 523 GLN 523 505 ?   ?   ?   B . n 
B 2 524 ARG 524 506 ?   ?   ?   B . n 
B 2 525 ASP 525 507 ?   ?   ?   B . n 
B 2 526 PRO 526 508 ?   ?   ?   B . n 
B 2 527 LYS 527 509 ?   ?   ?   B . n 
B 2 528 SER 528 510 ?   ?   ?   B . n 
B 2 529 ASN 529 511 ?   ?   ?   B . n 
# 
loop_
_pdbx_branch_scheme.asym_id 
_pdbx_branch_scheme.entity_id 
_pdbx_branch_scheme.mon_id 
_pdbx_branch_scheme.num 
_pdbx_branch_scheme.pdb_asym_id 
_pdbx_branch_scheme.pdb_mon_id 
_pdbx_branch_scheme.pdb_seq_num 
_pdbx_branch_scheme.auth_asym_id 
_pdbx_branch_scheme.auth_mon_id 
_pdbx_branch_scheme.auth_seq_num 
_pdbx_branch_scheme.hetero 
C 3 NAG 1 C NAG 1 A NAG 701 n 
C 3 NAG 2 C NAG 2 A NAG 702 n 
D 3 NAG 1 D NAG 1 A NAG 703 n 
D 3 NAG 2 D NAG 2 A NAG 704 n 
E 3 NAG 1 E NAG 1 A NAG 705 n 
E 3 NAG 2 E NAG 2 A NAG 706 n 
F 3 NAG 1 F NAG 1 A NAG 707 n 
F 3 NAG 2 F NAG 2 A NAG 708 n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 ARG ? ? ARG ? ? 'SUBJECT OF INVESTIGATION' ? 
2 NAG ? ? NAG ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
G 4 ARG 1 601 601 ARG ARG B . 
H 5 HOH 1 701 1   HOH HOH B . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9KJU 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9KJU 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9KJU 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     9KJU 
_struct.title                        'Local refinement of the y+LAT1-4F2hc bound with Arg' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9KJU 
_struct_keywords.text            'complex, membrane protein, amino acid' 
_struct_keywords.pdbx_keywords   'MEMBRANE PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
E N N 3 ? 
F N N 3 ? 
G N N 4 ? 
H N N 5 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP 4F2_HUMAN   P08195 ? 1 
;ELQPPEASIAVVSIPRQLPGSHSEAGVQGLSAGDDSELGSHCVAQTGLELLASGDPLPSASQNAEMIETGSDCVTQAGLQ
LLASSDPPALASKNAEVTGTMSQDTEVDMKEVELNELEPEKQPMNAASGAAMSLAGAEKNGLVKIKVAEDEAEAAAAAKF
TGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPAQKWWHTGALYRIGDLQAFQGHGAGNL
AGLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQTDLLQIDPNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGENSWFST
QVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLT
SSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLMLFTLPGTPVFSYGDEIGLDAAALPG
QPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFSAGPGLFSYIRHWDQNE
RFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYAA
;
2 
2 UNP YLAT1_HUMAN Q9UM01 ? 2 
;VDSTEYEVASQPEVETSPLGDGASPGPEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLIYSASFGLSLVIWAVGGL
FSVFGALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLLIIEPTSQAIIAITFANYMVQPLFPSCFAPYAASRLL
AAACICLLTFINCAYVKWGTLVQDIFTYAKVLALIAVIVAGIVRLGQGASTHFENSFEGSSFAVGDIALALYSALFSYSG
WDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYTVLDMRDILASDAVAVTFADQIFGIFNWIIPLSVALSCF
GGLNASIVAASRLFFVGSREGHLPDAICMIHVERFTPVPSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQL
YLRWKEPDRPRPLKLSVFFPIVFCLCTIFLVAVPLYSDTINSLIGIAIALSGLPFYFLIIRVPEHKRPLYLRRIVGSATR
YLQVLCMSVAAEMDLEDGGEMPKQRDPKSN
;
2 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9KJU A 14 ? 642 ? P08195 2 ? 630 ? 3 631 
2 2 9KJU B 20 ? 529 ? Q9UM01 2 ? 511 ? 2 511 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9KJU HIS A 1   ? UNP P08195 ? ? 'expression tag' -10 1  
1 9KJU HIS A 2   ? UNP P08195 ? ? 'expression tag' -9  2  
1 9KJU HIS A 3   ? UNP P08195 ? ? 'expression tag' -8  3  
1 9KJU HIS A 4   ? UNP P08195 ? ? 'expression tag' -7  4  
1 9KJU HIS A 5   ? UNP P08195 ? ? 'expression tag' -6  5  
1 9KJU HIS A 6   ? UNP P08195 ? ? 'expression tag' -5  6  
1 9KJU HIS A 7   ? UNP P08195 ? ? 'expression tag' -4  7  
1 9KJU HIS A 8   ? UNP P08195 ? ? 'expression tag' -3  8  
1 9KJU HIS A 9   ? UNP P08195 ? ? 'expression tag' -2  9  
1 9KJU HIS A 10  ? UNP P08195 ? ? 'expression tag' -1  10 
1 9KJU SER A 11  ? UNP P08195 ? ? 'expression tag' 0   11 
1 9KJU GLY A 12  ? UNP P08195 ? ? 'expression tag' 1   12 
1 9KJU ARG A 13  ? UNP P08195 ? ? 'expression tag' 2   13 
1 9KJU THR A 643 ? UNP P08195 ? ? 'expression tag' 632 14 
1 9KJU GLY A 644 ? UNP P08195 ? ? 'expression tag' 633 15 
1 9KJU ALA A 645 ? UNP P08195 ? ? 'expression tag' 634 16 
2 9KJU ASP B 1   ? UNP Q9UM01 ? ? 'expression tag' -17 17 
2 9KJU TYR B 2   ? UNP Q9UM01 ? ? 'expression tag' -16 18 
2 9KJU LYS B 3   ? UNP Q9UM01 ? ? 'expression tag' -15 19 
2 9KJU ASP B 4   ? UNP Q9UM01 ? ? 'expression tag' -14 20 
2 9KJU ASP B 5   ? UNP Q9UM01 ? ? 'expression tag' -13 21 
2 9KJU ASP B 6   ? UNP Q9UM01 ? ? 'expression tag' -12 22 
2 9KJU ASP B 7   ? UNP Q9UM01 ? ? 'expression tag' -11 23 
2 9KJU LYS B 8   ? UNP Q9UM01 ? ? 'expression tag' -10 24 
2 9KJU SER B 9   ? UNP Q9UM01 ? ? 'expression tag' -9  25 
2 9KJU GLY B 10  ? UNP Q9UM01 ? ? 'expression tag' -8  26 
2 9KJU PRO B 11  ? UNP Q9UM01 ? ? 'expression tag' -7  27 
2 9KJU ASP B 12  ? UNP Q9UM01 ? ? 'expression tag' -6  28 
2 9KJU GLU B 13  ? UNP Q9UM01 ? ? 'expression tag' -5  29 
2 9KJU VAL B 14  ? UNP Q9UM01 ? ? 'expression tag' -4  30 
2 9KJU ASP B 15  ? UNP Q9UM01 ? ? 'expression tag' -3  31 
2 9KJU ALA B 16  ? UNP Q9UM01 ? ? 'expression tag' -2  32 
2 9KJU SER B 17  ? UNP Q9UM01 ? ? 'expression tag' -1  33 
2 9KJU GLY B 18  ? UNP Q9UM01 ? ? 'expression tag' 0   34 
2 9KJU ARG B 19  ? UNP Q9UM01 ? ? 'expression tag' 1   35 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 177 ? ALA A 185 ? SER A 166 ALA A 174 1 ? 9  
HELX_P HELX_P2  AA2 TRP A 190 ? VAL A 217 ? TRP A 179 VAL A 206 1 ? 28 
HELX_P HELX_P3  AA3 LYS A 229 ? THR A 233 ? LYS A 218 THR A 222 5 ? 5  
HELX_P HELX_P4  AA4 LEU A 242 ? GLY A 247 ? LEU A 231 GLY A 236 1 ? 6  
HELX_P HELX_P5  AA5 ALA A 254 ? GLY A 258 ? ALA A 243 GLY A 247 5 ? 5  
HELX_P HELX_P6  AA6 ARG A 259 ? LYS A 267 ? ARG A 248 LYS A 256 1 ? 9  
HELX_P HELX_P7  AA7 SER A 298 ? LYS A 312 ? SER A 287 LYS A 301 1 ? 15 
HELX_P HELX_P8  AA8 VAL A 335 ? GLY A 353 ? VAL A 324 GLY A 342 1 ? 19 
HELX_P HELX_P9  AA9 ASP A 361 ? LEU A 365 ? ASP A 350 LEU A 354 5 ? 5  
HELX_P HELX_P10 AB1 ASP A 367 ? SER A 383 ? ASP A 356 SER A 372 1 ? 17 
HELX_P HELX_P11 AB2 ASP A 396 ? LEU A 403 ? ASP A 385 LEU A 392 1 ? 8  
HELX_P HELX_P12 AB3 THR A 423 ? GLY A 439 ? THR A 412 GLY A 428 1 ? 17 
HELX_P HELX_P13 AB4 LEU A 452 ? PHE A 456 ? LEU A 441 PHE A 445 5 ? 5  
HELX_P HELX_P14 AB5 PRO A 458 ? GLN A 460 ? PRO A 447 GLN A 449 5 ? 3  
HELX_P HELX_P15 AB6 LEU A 461 ? THR A 471 ? LEU A 450 THR A 460 1 ? 11 
HELX_P HELX_P16 AB7 THR A 520 ? SER A 525 ? THR A 509 SER A 514 1 ? 6  
HELX_P HELX_P17 AB8 SER A 530 ? SER A 543 ? SER A 519 SER A 532 1 ? 14 
HELX_P HELX_P18 AB9 GLU A 545 ? HIS A 550 ? GLU A 534 HIS A 539 1 ? 6  
HELX_P HELX_P19 AC1 PRO A 596 ? SER A 600 ? PRO A 585 SER A 589 5 ? 5  
HELX_P HELX_P20 AC2 SER B 56  ? ILE B 69  ? SER B 38  ILE B 51  1 ? 14 
HELX_P HELX_P21 AC3 SER B 71  ? SER B 76  ? SER B 53  SER B 58  1 ? 6  
HELX_P HELX_P22 AC4 LYS B 78  ? ALA B 85  ? LYS B 60  ALA B 67  1 ? 8  
HELX_P HELX_P23 AC5 SER B 86  ? LYS B 116 ? SER B 68  LYS B 98  1 ? 31 
HELX_P HELX_P24 AC6 SER B 121 ? GLY B 130 ? SER B 103 GLY B 112 1 ? 10 
HELX_P HELX_P25 AC7 GLY B 131 ? ILE B 144 ? GLY B 113 ILE B 126 1 ? 14 
HELX_P HELX_P26 AC8 ILE B 144 ? VAL B 162 ? ILE B 126 VAL B 144 1 ? 19 
HELX_P HELX_P27 AC9 PRO B 172 ? TYR B 194 ? PRO B 154 TYR B 176 1 ? 23 
HELX_P HELX_P28 AD1 TYR B 194 ? GLY B 227 ? TYR B 176 GLY B 209 1 ? 34 
HELX_P HELX_P29 AD2 ALA B 242 ? TYR B 257 ? ALA B 224 TYR B 239 1 ? 16 
HELX_P HELX_P30 AD3 THR B 262 ? ILE B 270 ? THR B 244 ILE B 252 5 ? 9  
HELX_P HELX_P31 AD4 ASN B 272 ? LEU B 303 ? ASN B 254 LEU B 285 1 ? 32 
HELX_P HELX_P32 AD5 ASP B 304 ? LEU B 309 ? ASP B 286 LEU B 291 1 ? 6  
HELX_P HELX_P33 AD6 ALA B 313 ? PHE B 323 ? ALA B 295 PHE B 305 1 ? 11 
HELX_P HELX_P34 AD7 TRP B 328 ? GLU B 359 ? TRP B 310 GLU B 341 1 ? 32 
HELX_P HELX_P35 AD8 PRO B 363 ? MET B 368 ? PRO B 345 MET B 350 5 ? 6  
HELX_P HELX_P36 AD9 PRO B 376 ? LEU B 391 ? PRO B 358 LEU B 373 1 ? 16 
HELX_P HELX_P37 AE1 ILE B 396 ? TYR B 402 ? ILE B 378 TYR B 384 5 ? 7  
HELX_P HELX_P38 AE2 TYR B 403 ? GLU B 425 ? TYR B 385 GLU B 407 1 ? 23 
HELX_P HELX_P39 AE3 VAL B 436 ? SER B 456 ? VAL B 418 SER B 438 1 ? 21 
HELX_P HELX_P40 AE4 ASP B 457 ? SER B 470 ? ASP B 439 SER B 452 1 ? 14 
HELX_P HELX_P41 AE5 GLY B 471 ? ILE B 478 ? GLY B 453 ILE B 460 1 ? 8  
HELX_P HELX_P42 AE6 PRO B 487 ? MET B 506 ? PRO B 469 MET B 488 1 ? 20 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ?    ? A CYS 222 SG  ? ? ? 1_555 B CYS 169 SG ? ? A CYS 211 B CYS 151 1_555 ? ? ? ? ? ? ? 2.024 ? ?               
covale1 covale one  ? A ASN 377 ND2 ? ? ? 1_555 D NAG .   C1 ? ? A ASN 366 D NAG 1   1_555 ? ? ? ? ? ? ? 1.433 ? N-Glycosylation 
covale2 covale one  ? A ASN 393 ND2 ? ? ? 1_555 E NAG .   C1 ? ? A ASN 382 E NAG 1   1_555 ? ? ? ? ? ? ? 1.432 ? N-Glycosylation 
covale3 covale one  ? A ASN 436 ND2 ? ? ? 1_555 F NAG .   C1 ? ? A ASN 425 F NAG 1   1_555 ? ? ? ? ? ? ? 1.445 ? N-Glycosylation 
covale4 covale one  ? A ASN 518 ND2 ? ? ? 1_555 C NAG .   C1 ? ? A ASN 507 C NAG 1   1_555 ? ? ? ? ? ? ? 1.428 ? N-Glycosylation 
covale5 covale both ? C NAG .   O4  ? ? ? 1_555 C NAG .   C1 ? ? C NAG 1   C NAG 2   1_555 ? ? ? ? ? ? ? 1.448 ? ?               
covale6 covale both ? D NAG .   O4  ? ? ? 1_555 D NAG .   C1 ? ? D NAG 1   D NAG 2   1_555 ? ? ? ? ? ? ? 1.466 ? ?               
covale7 covale both ? E NAG .   O4  ? ? ? 1_555 E NAG .   C1 ? ? E NAG 1   E NAG 2   1_555 ? ? ? ? ? ? ? 1.442 ? ?               
covale8 covale both ? F NAG .   O4  ? ? ? 1_555 F NAG .   C1 ? ? F NAG 1   F NAG 2   1_555 ? ? ? ? ? ? ? 1.451 ? ?               
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 NAG C .   ? ASN A 518 ? NAG C 1   ? 1_555 ASN A 507 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2 NAG D .   ? ASN A 377 ? NAG D 1   ? 1_555 ASN A 366 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
3 NAG E .   ? ASN A 393 ? NAG E 1   ? 1_555 ASN A 382 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
4 NAG F .   ? ASN A 436 ? NAG F 1   ? 1_555 ASN A 425 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
5 CYS A 222 ? CYS B 169 ? CYS A 211 ? 1_555 CYS B 151 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 8 ? 
AA2 ? 2 ? 
AA3 ? 4 ? 
AA4 ? 2 ? 
AA5 ? 2 ? 
AA6 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA1 5 6 ? parallel      
AA1 6 7 ? parallel      
AA1 7 8 ? parallel      
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA6 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 LEU A 411 ? THR A 413 ? LEU A 400 THR A 402 
AA1 2 LEU A 387 ? GLY A 391 ? LEU A 376 GLY A 380 
AA1 3 GLY A 356 ? VAL A 359 ? GLY A 345 VAL A 348 
AA1 4 ARG A 315 ? ASP A 319 ? ARG A 304 ASP A 308 
AA1 5 GLY A 270 ? LEU A 273 ? GLY A 259 LEU A 262 
AA1 6 LEU A 236 ? ILE A 239 ? LEU A 225 ILE A 228 
AA1 7 GLY A 474 ? SER A 479 ? GLY A 463 SER A 468 
AA1 8 CYS A 443 ? TRP A 445 ? CYS A 432 TRP A 434 
AA2 1 HIS A 277 ? LYS A 278 ? HIS A 266 LYS A 267 
AA2 2 ASP A 288 ? ILE A 292 ? ASP A 277 ILE A 281 
AA3 1 ASP A 552 ? PHE A 556 ? ASP A 541 PHE A 545 
AA3 2 LEU A 562 ? HIS A 568 ? LEU A 551 HIS A 557 
AA3 3 ARG A 574 ? ASN A 580 ? ARG A 563 ASN A 569 
AA3 4 GLY A 633 ? PHE A 638 ? GLY A 622 PHE A 627 
AA4 1 LEU A 586 ? SER A 587 ? LEU A 575 SER A 576 
AA4 2 LYS A 627 ? LEU A 628 ? LYS A 616 LEU A 617 
AA5 1 LYS A 604 ? ALA A 605 ? LYS A 593 ALA A 594 
AA5 2 LEU A 621 ? GLU A 622 ? LEU A 610 GLU A 611 
AA6 1 ILE B 369 ? HIS B 370 ? ILE B 351 HIS B 352 
AA6 2 SER B 507 ? VAL B 508 ? SER B 489 VAL B 490 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O THR A 413 ? O THR A 402 N ALA A 390 ? N ALA A 379 
AA1 2 3 O ILE A 389 ? O ILE A 378 N VAL A 359 ? N VAL A 348 
AA1 3 4 O GLY A 356 ? O GLY A 345 N LEU A 318 ? N LEU A 307 
AA1 4 5 O ILE A 317 ? O ILE A 306 N LEU A 271 ? N LEU A 260 
AA1 5 6 O VAL A 272 ? O VAL A 261 N TYR A 237 ? N TYR A 226 
AA1 6 7 N ARG A 238 ? N ARG A 227 O PHE A 478 ? O PHE A 467 
AA1 7 8 O THR A 475 ? O THR A 464 N TRP A 445 ? N TRP A 434 
AA2 1 2 N LYS A 278 ? N LYS A 267 O GLN A 291 ? O GLN A 280 
AA3 1 2 N ASP A 552 ? N ASP A 541 O HIS A 568 ? O HIS A 557 
AA3 2 3 N TYR A 565 ? N TYR A 554 O VAL A 577 ? O VAL A 566 
AA3 3 4 N ARG A 574 ? N ARG A 563 O PHE A 638 ? O PHE A 627 
AA4 1 2 N LEU A 586 ? N LEU A 575 O LEU A 628 ? O LEU A 617 
AA5 1 2 N ALA A 605 ? N ALA A 594 O LEU A 621 ? O LEU A 610 
AA6 1 2 N ILE B 369 ? N ILE B 351 O VAL B 508 ? O VAL B 490 
# 
_pdbx_entry_details.entry_id                   9KJU 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 PHE A 162 ? ? -140.16 17.41   
2  1 ALA A 174 ? ? -95.38  51.07   
3  1 PRO A 209 ? ? -65.28  -74.25  
4  1 ARG A 210 ? ? 177.27  175.25  
5  1 ALA A 216 ? ? 57.26   70.46   
6  1 GLN A 235 ? ? -96.90  -62.16  
7  1 ALA A 239 ? ? -87.79  31.97   
8  1 GLN A 269 ? ? -90.17  -72.02  
9  1 LYS A 270 ? ? -167.65 -164.51 
10 1 ASP A 271 ? ? -44.77  -7.23   
11 1 SER A 287 ? ? -125.80 -168.42 
12 1 ASN A 312 ? ? -100.79 73.27   
13 1 PHE A 320 ? ? 59.61   73.70   
14 1 SER A 321 ? ? -53.30  -9.46   
15 1 ASP A 374 ? ? -98.40  33.00   
16 1 SER A 404 ? ? -97.94  31.80   
17 1 PRO A 481 ? ? -57.59  -172.72 
18 1 GLN A 483 ? ? 167.02  148.03  
19 1 ALA A 487 ? ? -150.93 82.79   
20 1 ASP A 493 ? ? -124.15 -168.36 
21 1 ILE A 500 ? ? 48.89   77.86   
22 1 HIS A 539 ? ? -146.37 30.34   
23 1 ALA A 547 ? ? -144.90 -159.71 
24 1 TRP A 558 ? ? -99.51  -74.65  
25 1 ASP A 559 ? ? -133.79 -65.39  
26 1 GLN A 560 ? ? -142.38 16.53   
27 1 PHE A 570 ? ? -92.21  52.57   
28 1 ASP A 572 ? ? -95.22  42.55   
29 1 ALA A 581 ? ? -68.09  -78.13  
30 1 SER A 582 ? ? 57.88   -1.43   
31 1 ASP A 595 ? ? -72.55  -166.15 
32 1 LEU A 612 ? ? -96.07  46.23   
33 1 LYS B 34  ? ? 60.76   78.29   
34 1 SER B 58  ? ? -155.14 75.04   
35 1 PRO B 59  ? ? -89.92  49.94   
36 1 ALA B 102 ? ? 73.13   -16.99  
37 1 SER B 103 ? ? -146.14 -23.66  
38 1 ALA B 110 ? ? -94.47  -60.20  
39 1 CYS B 151 ? ? -140.95 -15.73  
40 1 PHE B 214 ? ? -99.07  59.17   
41 1 PHE B 223 ? ? -90.89  50.23   
42 1 LEU B 344 ? ? 54.00   81.87   
43 1 PRO B 345 ? ? -39.23  142.49  
44 1 ASP B 346 ? ? -64.04  4.67    
45 1 PHE B 356 ? ? -68.53  82.92   
46 1 SER B 452 ? ? -68.44  4.39    
47 1 ILE B 460 ? ? -126.61 -52.40  
48 1 HIS B 466 ? ? 49.57   23.80   
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9KJU 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9KJU 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  2.7 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               343068 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.5 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Overall structure of the y+LAT1-4F2hc bound with Arg' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1,2 
# 
_em_imaging.entry_id                        9KJU 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               OTHER 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1200 
_em_imaging.nominal_defocus_max             5000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              9KJU 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9KJU 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A HIS -10 ? A HIS 1   
2   1 Y 1 A HIS -9  ? A HIS 2   
3   1 Y 1 A HIS -8  ? A HIS 3   
4   1 Y 1 A HIS -7  ? A HIS 4   
5   1 Y 1 A HIS -6  ? A HIS 5   
6   1 Y 1 A HIS -5  ? A HIS 6   
7   1 Y 1 A HIS -4  ? A HIS 7   
8   1 Y 1 A HIS -3  ? A HIS 8   
9   1 Y 1 A HIS -2  ? A HIS 9   
10  1 Y 1 A HIS -1  ? A HIS 10  
11  1 Y 1 A SER 0   ? A SER 11  
12  1 Y 1 A GLY 1   ? A GLY 12  
13  1 Y 1 A ARG 2   ? A ARG 13  
14  1 Y 1 A GLU 3   ? A GLU 14  
15  1 Y 1 A LEU 4   ? A LEU 15  
16  1 Y 1 A GLN 5   ? A GLN 16  
17  1 Y 1 A PRO 6   ? A PRO 17  
18  1 Y 1 A PRO 7   ? A PRO 18  
19  1 Y 1 A GLU 8   ? A GLU 19  
20  1 Y 1 A ALA 9   ? A ALA 20  
21  1 Y 1 A SER 10  ? A SER 21  
22  1 Y 1 A ILE 11  ? A ILE 22  
23  1 Y 1 A ALA 12  ? A ALA 23  
24  1 Y 1 A VAL 13  ? A VAL 24  
25  1 Y 1 A VAL 14  ? A VAL 25  
26  1 Y 1 A SER 15  ? A SER 26  
27  1 Y 1 A ILE 16  ? A ILE 27  
28  1 Y 1 A PRO 17  ? A PRO 28  
29  1 Y 1 A ARG 18  ? A ARG 29  
30  1 Y 1 A GLN 19  ? A GLN 30  
31  1 Y 1 A LEU 20  ? A LEU 31  
32  1 Y 1 A PRO 21  ? A PRO 32  
33  1 Y 1 A GLY 22  ? A GLY 33  
34  1 Y 1 A SER 23  ? A SER 34  
35  1 Y 1 A HIS 24  ? A HIS 35  
36  1 Y 1 A SER 25  ? A SER 36  
37  1 Y 1 A GLU 26  ? A GLU 37  
38  1 Y 1 A ALA 27  ? A ALA 38  
39  1 Y 1 A GLY 28  ? A GLY 39  
40  1 Y 1 A VAL 29  ? A VAL 40  
41  1 Y 1 A GLN 30  ? A GLN 41  
42  1 Y 1 A GLY 31  ? A GLY 42  
43  1 Y 1 A LEU 32  ? A LEU 43  
44  1 Y 1 A SER 33  ? A SER 44  
45  1 Y 1 A ALA 34  ? A ALA 45  
46  1 Y 1 A GLY 35  ? A GLY 46  
47  1 Y 1 A ASP 36  ? A ASP 47  
48  1 Y 1 A ASP 37  ? A ASP 48  
49  1 Y 1 A SER 38  ? A SER 49  
50  1 Y 1 A GLU 39  ? A GLU 50  
51  1 Y 1 A LEU 40  ? A LEU 51  
52  1 Y 1 A GLY 41  ? A GLY 52  
53  1 Y 1 A SER 42  ? A SER 53  
54  1 Y 1 A HIS 43  ? A HIS 54  
55  1 Y 1 A CYS 44  ? A CYS 55  
56  1 Y 1 A VAL 45  ? A VAL 56  
57  1 Y 1 A ALA 46  ? A ALA 57  
58  1 Y 1 A GLN 47  ? A GLN 58  
59  1 Y 1 A THR 48  ? A THR 59  
60  1 Y 1 A GLY 49  ? A GLY 60  
61  1 Y 1 A LEU 50  ? A LEU 61  
62  1 Y 1 A GLU 51  ? A GLU 62  
63  1 Y 1 A LEU 52  ? A LEU 63  
64  1 Y 1 A LEU 53  ? A LEU 64  
65  1 Y 1 A ALA 54  ? A ALA 65  
66  1 Y 1 A SER 55  ? A SER 66  
67  1 Y 1 A GLY 56  ? A GLY 67  
68  1 Y 1 A ASP 57  ? A ASP 68  
69  1 Y 1 A PRO 58  ? A PRO 69  
70  1 Y 1 A LEU 59  ? A LEU 70  
71  1 Y 1 A PRO 60  ? A PRO 71  
72  1 Y 1 A SER 61  ? A SER 72  
73  1 Y 1 A ALA 62  ? A ALA 73  
74  1 Y 1 A SER 63  ? A SER 74  
75  1 Y 1 A GLN 64  ? A GLN 75  
76  1 Y 1 A ASN 65  ? A ASN 76  
77  1 Y 1 A ALA 66  ? A ALA 77  
78  1 Y 1 A GLU 67  ? A GLU 78  
79  1 Y 1 A MET 68  ? A MET 79  
80  1 Y 1 A ILE 69  ? A ILE 80  
81  1 Y 1 A GLU 70  ? A GLU 81  
82  1 Y 1 A THR 71  ? A THR 82  
83  1 Y 1 A GLY 72  ? A GLY 83  
84  1 Y 1 A SER 73  ? A SER 84  
85  1 Y 1 A ASP 74  ? A ASP 85  
86  1 Y 1 A CYS 75  ? A CYS 86  
87  1 Y 1 A VAL 76  ? A VAL 87  
88  1 Y 1 A THR 77  ? A THR 88  
89  1 Y 1 A GLN 78  ? A GLN 89  
90  1 Y 1 A ALA 79  ? A ALA 90  
91  1 Y 1 A GLY 80  ? A GLY 91  
92  1 Y 1 A LEU 81  ? A LEU 92  
93  1 Y 1 A GLN 82  ? A GLN 93  
94  1 Y 1 A LEU 83  ? A LEU 94  
95  1 Y 1 A LEU 84  ? A LEU 95  
96  1 Y 1 A ALA 85  ? A ALA 96  
97  1 Y 1 A SER 86  ? A SER 97  
98  1 Y 1 A SER 87  ? A SER 98  
99  1 Y 1 A ASP 88  ? A ASP 99  
100 1 Y 1 A PRO 89  ? A PRO 100 
101 1 Y 1 A PRO 90  ? A PRO 101 
102 1 Y 1 A ALA 91  ? A ALA 102 
103 1 Y 1 A LEU 92  ? A LEU 103 
104 1 Y 1 A ALA 93  ? A ALA 104 
105 1 Y 1 A SER 94  ? A SER 105 
106 1 Y 1 A LYS 95  ? A LYS 106 
107 1 Y 1 A ASN 96  ? A ASN 107 
108 1 Y 1 A ALA 97  ? A ALA 108 
109 1 Y 1 A GLU 98  ? A GLU 109 
110 1 Y 1 A VAL 99  ? A VAL 110 
111 1 Y 1 A THR 100 ? A THR 111 
112 1 Y 1 A GLY 101 ? A GLY 112 
113 1 Y 1 A THR 102 ? A THR 113 
114 1 Y 1 A MET 103 ? A MET 114 
115 1 Y 1 A SER 104 ? A SER 115 
116 1 Y 1 A GLN 105 ? A GLN 116 
117 1 Y 1 A ASP 106 ? A ASP 117 
118 1 Y 1 A THR 107 ? A THR 118 
119 1 Y 1 A GLU 108 ? A GLU 119 
120 1 Y 1 A VAL 109 ? A VAL 120 
121 1 Y 1 A ASP 110 ? A ASP 121 
122 1 Y 1 A MET 111 ? A MET 122 
123 1 Y 1 A LYS 112 ? A LYS 123 
124 1 Y 1 A GLU 113 ? A GLU 124 
125 1 Y 1 A VAL 114 ? A VAL 125 
126 1 Y 1 A GLU 115 ? A GLU 126 
127 1 Y 1 A LEU 116 ? A LEU 127 
128 1 Y 1 A ASN 117 ? A ASN 128 
129 1 Y 1 A GLU 118 ? A GLU 129 
130 1 Y 1 A LEU 119 ? A LEU 130 
131 1 Y 1 A GLU 120 ? A GLU 131 
132 1 Y 1 A PRO 121 ? A PRO 132 
133 1 Y 1 A GLU 122 ? A GLU 133 
134 1 Y 1 A LYS 123 ? A LYS 134 
135 1 Y 1 A GLN 124 ? A GLN 135 
136 1 Y 1 A PRO 125 ? A PRO 136 
137 1 Y 1 A MET 126 ? A MET 137 
138 1 Y 1 A ASN 127 ? A ASN 138 
139 1 Y 1 A ALA 128 ? A ALA 139 
140 1 Y 1 A ALA 129 ? A ALA 140 
141 1 Y 1 A SER 130 ? A SER 141 
142 1 Y 1 A GLY 131 ? A GLY 142 
143 1 Y 1 A ALA 132 ? A ALA 143 
144 1 Y 1 A ALA 133 ? A ALA 144 
145 1 Y 1 A MET 134 ? A MET 145 
146 1 Y 1 A SER 135 ? A SER 146 
147 1 Y 1 A LEU 136 ? A LEU 147 
148 1 Y 1 A ALA 137 ? A ALA 148 
149 1 Y 1 A GLY 138 ? A GLY 149 
150 1 Y 1 A ALA 139 ? A ALA 150 
151 1 Y 1 A GLU 140 ? A GLU 151 
152 1 Y 1 A LYS 141 ? A LYS 152 
153 1 Y 1 A ASN 142 ? A ASN 153 
154 1 Y 1 A GLY 143 ? A GLY 154 
155 1 Y 1 A LEU 144 ? A LEU 155 
156 1 Y 1 A VAL 145 ? A VAL 156 
157 1 Y 1 A LYS 146 ? A LYS 157 
158 1 Y 1 A ILE 147 ? A ILE 158 
159 1 Y 1 A LYS 148 ? A LYS 159 
160 1 Y 1 A VAL 149 ? A VAL 160 
161 1 Y 1 A ALA 150 ? A ALA 161 
162 1 Y 1 A GLU 151 ? A GLU 162 
163 1 Y 1 A ASP 152 ? A ASP 163 
164 1 Y 1 A GLU 153 ? A GLU 164 
165 1 Y 1 A ALA 154 ? A ALA 165 
166 1 Y 1 A GLU 155 ? A GLU 166 
167 1 Y 1 A ALA 156 ? A ALA 167 
168 1 Y 1 A ALA 157 ? A ALA 168 
169 1 Y 1 A ALA 158 ? A ALA 169 
170 1 Y 1 A ALA 159 ? A ALA 170 
171 1 Y 1 A ALA 160 ? A ALA 171 
172 1 Y 1 A THR 632 ? A THR 643 
173 1 Y 1 A GLY 633 ? A GLY 644 
174 1 Y 1 A ALA 634 ? A ALA 645 
175 1 Y 1 B ASP -17 ? B ASP 1   
176 1 Y 1 B TYR -16 ? B TYR 2   
177 1 Y 1 B LYS -15 ? B LYS 3   
178 1 Y 1 B ASP -14 ? B ASP 4   
179 1 Y 1 B ASP -13 ? B ASP 5   
180 1 Y 1 B ASP -12 ? B ASP 6   
181 1 Y 1 B ASP -11 ? B ASP 7   
182 1 Y 1 B LYS -10 ? B LYS 8   
183 1 Y 1 B SER -9  ? B SER 9   
184 1 Y 1 B GLY -8  ? B GLY 10  
185 1 Y 1 B PRO -7  ? B PRO 11  
186 1 Y 1 B ASP -6  ? B ASP 12  
187 1 Y 1 B GLU -5  ? B GLU 13  
188 1 Y 1 B VAL -4  ? B VAL 14  
189 1 Y 1 B ASP -3  ? B ASP 15  
190 1 Y 1 B ALA -2  ? B ALA 16  
191 1 Y 1 B SER -1  ? B SER 17  
192 1 Y 1 B GLY 0   ? B GLY 18  
193 1 Y 1 B ARG 1   ? B ARG 19  
194 1 Y 1 B VAL 2   ? B VAL 20  
195 1 Y 1 B ASP 3   ? B ASP 21  
196 1 Y 1 B SER 4   ? B SER 22  
197 1 Y 1 B THR 5   ? B THR 23  
198 1 Y 1 B GLU 6   ? B GLU 24  
199 1 Y 1 B TYR 7   ? B TYR 25  
200 1 Y 1 B GLU 8   ? B GLU 26  
201 1 Y 1 B VAL 9   ? B VAL 27  
202 1 Y 1 B ALA 10  ? B ALA 28  
203 1 Y 1 B SER 11  ? B SER 29  
204 1 Y 1 B GLN 12  ? B GLN 30  
205 1 Y 1 B PRO 13  ? B PRO 31  
206 1 Y 1 B GLU 14  ? B GLU 32  
207 1 Y 1 B VAL 15  ? B VAL 33  
208 1 Y 1 B GLU 16  ? B GLU 34  
209 1 Y 1 B THR 17  ? B THR 35  
210 1 Y 1 B SER 18  ? B SER 36  
211 1 Y 1 B PRO 19  ? B PRO 37  
212 1 Y 1 B LEU 20  ? B LEU 38  
213 1 Y 1 B GLY 21  ? B GLY 39  
214 1 Y 1 B ASP 22  ? B ASP 40  
215 1 Y 1 B GLY 23  ? B GLY 41  
216 1 Y 1 B ALA 24  ? B ALA 42  
217 1 Y 1 B SER 25  ? B SER 43  
218 1 Y 1 B PRO 26  ? B PRO 44  
219 1 Y 1 B GLY 27  ? B GLY 45  
220 1 Y 1 B PRO 28  ? B PRO 46  
221 1 Y 1 B GLU 29  ? B GLU 47  
222 1 Y 1 B MET 494 ? B MET 512 
223 1 Y 1 B ASP 495 ? B ASP 513 
224 1 Y 1 B LEU 496 ? B LEU 514 
225 1 Y 1 B GLU 497 ? B GLU 515 
226 1 Y 1 B ASP 498 ? B ASP 516 
227 1 Y 1 B GLY 499 ? B GLY 517 
228 1 Y 1 B GLY 500 ? B GLY 518 
229 1 Y 1 B GLU 501 ? B GLU 519 
230 1 Y 1 B MET 502 ? B MET 520 
231 1 Y 1 B PRO 503 ? B PRO 521 
232 1 Y 1 B LYS 504 ? B LYS 522 
233 1 Y 1 B GLN 505 ? B GLN 523 
234 1 Y 1 B ARG 506 ? B ARG 524 
235 1 Y 1 B ASP 507 ? B ASP 525 
236 1 Y 1 B PRO 508 ? B PRO 526 
237 1 Y 1 B LYS 509 ? B LYS 527 
238 1 Y 1 B SER 510 ? B SER 528 
239 1 Y 1 B ASN 511 ? B ASN 529 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
NAG C1   C N R 250 
NAG C2   C N R 251 
NAG C3   C N R 252 
NAG C4   C N S 253 
NAG C5   C N R 254 
NAG C6   C N N 255 
NAG C7   C N N 256 
NAG C8   C N N 257 
NAG N2   N N N 258 
NAG O1   O N N 259 
NAG O3   O N N 260 
NAG O4   O N N 261 
NAG O5   O N N 262 
NAG O6   O N N 263 
NAG O7   O N N 264 
NAG H1   H N N 265 
NAG H2   H N N 266 
NAG H3   H N N 267 
NAG H4   H N N 268 
NAG H5   H N N 269 
NAG H61  H N N 270 
NAG H62  H N N 271 
NAG H81  H N N 272 
NAG H82  H N N 273 
NAG H83  H N N 274 
NAG HN2  H N N 275 
NAG HO1  H N N 276 
NAG HO3  H N N 277 
NAG HO4  H N N 278 
NAG HO6  H N N 279 
PHE N    N N N 280 
PHE CA   C N S 281 
PHE C    C N N 282 
PHE O    O N N 283 
PHE CB   C N N 284 
PHE CG   C Y N 285 
PHE CD1  C Y N 286 
PHE CD2  C Y N 287 
PHE CE1  C Y N 288 
PHE CE2  C Y N 289 
PHE CZ   C Y N 290 
PHE OXT  O N N 291 
PHE H    H N N 292 
PHE H2   H N N 293 
PHE HA   H N N 294 
PHE HB2  H N N 295 
PHE HB3  H N N 296 
PHE HD1  H N N 297 
PHE HD2  H N N 298 
PHE HE1  H N N 299 
PHE HE2  H N N 300 
PHE HZ   H N N 301 
PHE HXT  H N N 302 
PRO N    N N N 303 
PRO CA   C N S 304 
PRO C    C N N 305 
PRO O    O N N 306 
PRO CB   C N N 307 
PRO CG   C N N 308 
PRO CD   C N N 309 
PRO OXT  O N N 310 
PRO H    H N N 311 
PRO HA   H N N 312 
PRO HB2  H N N 313 
PRO HB3  H N N 314 
PRO HG2  H N N 315 
PRO HG3  H N N 316 
PRO HD2  H N N 317 
PRO HD3  H N N 318 
PRO HXT  H N N 319 
SER N    N N N 320 
SER CA   C N S 321 
SER C    C N N 322 
SER O    O N N 323 
SER CB   C N N 324 
SER OG   O N N 325 
SER OXT  O N N 326 
SER H    H N N 327 
SER H2   H N N 328 
SER HA   H N N 329 
SER HB2  H N N 330 
SER HB3  H N N 331 
SER HG   H N N 332 
SER HXT  H N N 333 
THR N    N N N 334 
THR CA   C N S 335 
THR C    C N N 336 
THR O    O N N 337 
THR CB   C N R 338 
THR OG1  O N N 339 
THR CG2  C N N 340 
THR OXT  O N N 341 
THR H    H N N 342 
THR H2   H N N 343 
THR HA   H N N 344 
THR HB   H N N 345 
THR HG1  H N N 346 
THR HG21 H N N 347 
THR HG22 H N N 348 
THR HG23 H N N 349 
THR HXT  H N N 350 
TRP N    N N N 351 
TRP CA   C N S 352 
TRP C    C N N 353 
TRP O    O N N 354 
TRP CB   C N N 355 
TRP CG   C Y N 356 
TRP CD1  C Y N 357 
TRP CD2  C Y N 358 
TRP NE1  N Y N 359 
TRP CE2  C Y N 360 
TRP CE3  C Y N 361 
TRP CZ2  C Y N 362 
TRP CZ3  C Y N 363 
TRP CH2  C Y N 364 
TRP OXT  O N N 365 
TRP H    H N N 366 
TRP H2   H N N 367 
TRP HA   H N N 368 
TRP HB2  H N N 369 
TRP HB3  H N N 370 
TRP HD1  H N N 371 
TRP HE1  H N N 372 
TRP HE3  H N N 373 
TRP HZ2  H N N 374 
TRP HZ3  H N N 375 
TRP HH2  H N N 376 
TRP HXT  H N N 377 
TYR N    N N N 378 
TYR CA   C N S 379 
TYR C    C N N 380 
TYR O    O N N 381 
TYR CB   C N N 382 
TYR CG   C Y N 383 
TYR CD1  C Y N 384 
TYR CD2  C Y N 385 
TYR CE1  C Y N 386 
TYR CE2  C Y N 387 
TYR CZ   C Y N 388 
TYR OH   O N N 389 
TYR OXT  O N N 390 
TYR H    H N N 391 
TYR H2   H N N 392 
TYR HA   H N N 393 
TYR HB2  H N N 394 
TYR HB3  H N N 395 
TYR HD1  H N N 396 
TYR HD2  H N N 397 
TYR HE1  H N N 398 
TYR HE2  H N N 399 
TYR HH   H N N 400 
TYR HXT  H N N 401 
VAL N    N N N 402 
VAL CA   C N S 403 
VAL C    C N N 404 
VAL O    O N N 405 
VAL CB   C N N 406 
VAL CG1  C N N 407 
VAL CG2  C N N 408 
VAL OXT  O N N 409 
VAL H    H N N 410 
VAL H2   H N N 411 
VAL HA   H N N 412 
VAL HB   H N N 413 
VAL HG11 H N N 414 
VAL HG12 H N N 415 
VAL HG13 H N N 416 
VAL HG21 H N N 417 
VAL HG22 H N N 418 
VAL HG23 H N N 419 
VAL HXT  H N N 420 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
NAG C1  C2   sing N N 237 
NAG C1  O1   sing N N 238 
NAG C1  O5   sing N N 239 
NAG C1  H1   sing N N 240 
NAG C2  C3   sing N N 241 
NAG C2  N2   sing N N 242 
NAG C2  H2   sing N N 243 
NAG C3  C4   sing N N 244 
NAG C3  O3   sing N N 245 
NAG C3  H3   sing N N 246 
NAG C4  C5   sing N N 247 
NAG C4  O4   sing N N 248 
NAG C4  H4   sing N N 249 
NAG C5  C6   sing N N 250 
NAG C5  O5   sing N N 251 
NAG C5  H5   sing N N 252 
NAG C6  O6   sing N N 253 
NAG C6  H61  sing N N 254 
NAG C6  H62  sing N N 255 
NAG C7  C8   sing N N 256 
NAG C7  N2   sing N N 257 
NAG C7  O7   doub N N 258 
NAG C8  H81  sing N N 259 
NAG C8  H82  sing N N 260 
NAG C8  H83  sing N N 261 
NAG N2  HN2  sing N N 262 
NAG O1  HO1  sing N N 263 
NAG O3  HO3  sing N N 264 
NAG O4  HO4  sing N N 265 
NAG O6  HO6  sing N N 266 
PHE N   CA   sing N N 267 
PHE N   H    sing N N 268 
PHE N   H2   sing N N 269 
PHE CA  C    sing N N 270 
PHE CA  CB   sing N N 271 
PHE CA  HA   sing N N 272 
PHE C   O    doub N N 273 
PHE C   OXT  sing N N 274 
PHE CB  CG   sing N N 275 
PHE CB  HB2  sing N N 276 
PHE CB  HB3  sing N N 277 
PHE CG  CD1  doub Y N 278 
PHE CG  CD2  sing Y N 279 
PHE CD1 CE1  sing Y N 280 
PHE CD1 HD1  sing N N 281 
PHE CD2 CE2  doub Y N 282 
PHE CD2 HD2  sing N N 283 
PHE CE1 CZ   doub Y N 284 
PHE CE1 HE1  sing N N 285 
PHE CE2 CZ   sing Y N 286 
PHE CE2 HE2  sing N N 287 
PHE CZ  HZ   sing N N 288 
PHE OXT HXT  sing N N 289 
PRO N   CA   sing N N 290 
PRO N   CD   sing N N 291 
PRO N   H    sing N N 292 
PRO CA  C    sing N N 293 
PRO CA  CB   sing N N 294 
PRO CA  HA   sing N N 295 
PRO C   O    doub N N 296 
PRO C   OXT  sing N N 297 
PRO CB  CG   sing N N 298 
PRO CB  HB2  sing N N 299 
PRO CB  HB3  sing N N 300 
PRO CG  CD   sing N N 301 
PRO CG  HG2  sing N N 302 
PRO CG  HG3  sing N N 303 
PRO CD  HD2  sing N N 304 
PRO CD  HD3  sing N N 305 
PRO OXT HXT  sing N N 306 
SER N   CA   sing N N 307 
SER N   H    sing N N 308 
SER N   H2   sing N N 309 
SER CA  C    sing N N 310 
SER CA  CB   sing N N 311 
SER CA  HA   sing N N 312 
SER C   O    doub N N 313 
SER C   OXT  sing N N 314 
SER CB  OG   sing N N 315 
SER CB  HB2  sing N N 316 
SER CB  HB3  sing N N 317 
SER OG  HG   sing N N 318 
SER OXT HXT  sing N N 319 
THR N   CA   sing N N 320 
THR N   H    sing N N 321 
THR N   H2   sing N N 322 
THR CA  C    sing N N 323 
THR CA  CB   sing N N 324 
THR CA  HA   sing N N 325 
THR C   O    doub N N 326 
THR C   OXT  sing N N 327 
THR CB  OG1  sing N N 328 
THR CB  CG2  sing N N 329 
THR CB  HB   sing N N 330 
THR OG1 HG1  sing N N 331 
THR CG2 HG21 sing N N 332 
THR CG2 HG22 sing N N 333 
THR CG2 HG23 sing N N 334 
THR OXT HXT  sing N N 335 
TRP N   CA   sing N N 336 
TRP N   H    sing N N 337 
TRP N   H2   sing N N 338 
TRP CA  C    sing N N 339 
TRP CA  CB   sing N N 340 
TRP CA  HA   sing N N 341 
TRP C   O    doub N N 342 
TRP C   OXT  sing N N 343 
TRP CB  CG   sing N N 344 
TRP CB  HB2  sing N N 345 
TRP CB  HB3  sing N N 346 
TRP CG  CD1  doub Y N 347 
TRP CG  CD2  sing Y N 348 
TRP CD1 NE1  sing Y N 349 
TRP CD1 HD1  sing N N 350 
TRP CD2 CE2  doub Y N 351 
TRP CD2 CE3  sing Y N 352 
TRP NE1 CE2  sing Y N 353 
TRP NE1 HE1  sing N N 354 
TRP CE2 CZ2  sing Y N 355 
TRP CE3 CZ3  doub Y N 356 
TRP CE3 HE3  sing N N 357 
TRP CZ2 CH2  doub Y N 358 
TRP CZ2 HZ2  sing N N 359 
TRP CZ3 CH2  sing Y N 360 
TRP CZ3 HZ3  sing N N 361 
TRP CH2 HH2  sing N N 362 
TRP OXT HXT  sing N N 363 
TYR N   CA   sing N N 364 
TYR N   H    sing N N 365 
TYR N   H2   sing N N 366 
TYR CA  C    sing N N 367 
TYR CA  CB   sing N N 368 
TYR CA  HA   sing N N 369 
TYR C   O    doub N N 370 
TYR C   OXT  sing N N 371 
TYR CB  CG   sing N N 372 
TYR CB  HB2  sing N N 373 
TYR CB  HB3  sing N N 374 
TYR CG  CD1  doub Y N 375 
TYR CG  CD2  sing Y N 376 
TYR CD1 CE1  sing Y N 377 
TYR CD1 HD1  sing N N 378 
TYR CD2 CE2  doub Y N 379 
TYR CD2 HD2  sing N N 380 
TYR CE1 CZ   doub Y N 381 
TYR CE1 HE1  sing N N 382 
TYR CE2 CZ   sing Y N 383 
TYR CE2 HE2  sing N N 384 
TYR CZ  OH   sing N N 385 
TYR OH  HH   sing N N 386 
TYR OXT HXT  sing N N 387 
VAL N   CA   sing N N 388 
VAL N   H    sing N N 389 
VAL N   H2   sing N N 390 
VAL CA  C    sing N N 391 
VAL CA  CB   sing N N 392 
VAL CA  HA   sing N N 393 
VAL C   O    doub N N 394 
VAL C   OXT  sing N N 395 
VAL CB  CG1  sing N N 396 
VAL CB  CG2  sing N N 397 
VAL CB  HB   sing N N 398 
VAL CG1 HG11 sing N N 399 
VAL CG1 HG12 sing N N 400 
VAL CG1 HG13 sing N N 401 
VAL CG2 HG21 sing N N 402 
VAL CG2 HG22 sing N N 403 
VAL CG2 HG23 sing N N 404 
VAL OXT HXT  sing N N 405 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-11-12 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           9KJU 
_em_admin.last_update        2025-04-02 
_em_admin.map_release_date   2025-04-02 
_em_admin.title              'Local refinement of the y+LAT1-4F2hc bound with Arg' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ? ? 
MASKING                    ? 3  ? ? ? ? ? 
'CTF CORRECTION'           ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ? ? 
'MODEL FITTING'            ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'         ? 8  ? ? ? ? ? 
OTHER                      ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ? ? 
CLASSIFICATION             ? 12 1 ? ? ? ? 
RECONSTRUCTION             ? 13 1 ? ? ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
loop_
_pdbx_entity_branch_list.entity_id 
_pdbx_entity_branch_list.comp_id 
_pdbx_entity_branch_list.num 
_pdbx_entity_branch_list.hetero 
3 NAG 1 n 
3 NAG 2 n 
# 
_atom_sites.entry_id                    9KJU 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . LYS A 1 172 ? 123.558 124.182 101.157 1.00 97.00  ?  161 LYS A N   1 
ATOM   2    C CA  . LYS A 1 172 ? 123.494 123.060 102.084 1.00 97.00  ?  161 LYS A CA  1 
ATOM   3    C C   . LYS A 1 172 ? 122.937 123.558 103.416 1.00 97.00  ?  161 LYS A C   1 
ATOM   4    O O   . LYS A 1 172 ? 121.726 123.540 103.639 1.00 97.00  ?  161 LYS A O   1 
ATOM   5    C CB  . LYS A 1 172 ? 124.881 122.424 102.260 1.00 97.00  ?  161 LYS A CB  1 
ATOM   6    C CG  . LYS A 1 172 ? 124.918 121.130 103.075 1.00 97.00  ?  161 LYS A CG  1 
ATOM   7    C CD  . LYS A 1 172 ? 124.300 119.967 102.319 1.00 97.00  ?  161 LYS A CD  1 
ATOM   8    C CE  . LYS A 1 172 ? 124.482 118.662 103.079 1.00 97.00  ?  161 LYS A CE  1 
ATOM   9    N NZ  . LYS A 1 172 ? 123.850 117.507 102.383 1.00 97.00  1  161 LYS A NZ  1 
ATOM   10   N N   . PHE A 1 173 ? 123.831 124.013 104.297 1.00 92.78  ?  162 PHE A N   1 
ATOM   11   C CA  . PHE A 1 173 ? 123.424 124.604 105.564 1.00 92.78  ?  162 PHE A CA  1 
ATOM   12   C C   . PHE A 1 173 ? 124.275 125.814 105.928 1.00 92.78  ?  162 PHE A C   1 
ATOM   13   O O   . PHE A 1 173 ? 124.283 126.216 107.098 1.00 92.78  ?  162 PHE A O   1 
ATOM   14   C CB  . PHE A 1 173 ? 123.483 123.570 106.692 1.00 92.78  ?  162 PHE A CB  1 
ATOM   15   C CG  . PHE A 1 173 ? 122.352 122.585 106.668 1.00 92.78  ?  162 PHE A CG  1 
ATOM   16   C CD1 . PHE A 1 173 ? 121.048 123.003 106.875 1.00 92.78  ?  162 PHE A CD1 1 
ATOM   17   C CD2 . PHE A 1 173 ? 122.594 121.240 106.439 1.00 92.78  ?  162 PHE A CD2 1 
ATOM   18   C CE1 . PHE A 1 173 ? 120.005 122.099 106.852 1.00 92.78  ?  162 PHE A CE1 1 
ATOM   19   C CE2 . PHE A 1 173 ? 121.557 120.329 106.415 1.00 92.78  ?  162 PHE A CE2 1 
ATOM   20   C CZ  . PHE A 1 173 ? 120.260 120.759 106.623 1.00 92.78  ?  162 PHE A CZ  1 
ATOM   21   N N   . THR A 1 174 ? 124.993 126.396 104.972 1.00 86.72  ?  163 THR A N   1 
ATOM   22   C CA  . THR A 1 174 ? 125.841 127.539 105.258 1.00 86.72  ?  163 THR A CA  1 
ATOM   23   C C   . THR A 1 174 ? 124.998 128.799 105.431 1.00 86.72  ?  163 THR A C   1 
ATOM   24   O O   . THR A 1 174 ? 123.815 128.845 105.083 1.00 86.72  ?  163 THR A O   1 
ATOM   25   C CB  . THR A 1 174 ? 126.870 127.732 104.142 1.00 86.72  ?  163 THR A CB  1 
ATOM   26   O OG1 . THR A 1 174 ? 127.796 128.761 104.510 1.00 86.72  ?  163 THR A OG1 1 
ATOM   27   C CG2 . THR A 1 174 ? 126.184 128.111 102.837 1.00 86.72  ?  163 THR A CG2 1 
ATOM   28   N N   . GLY A 1 175 ? 125.625 129.831 105.988 1.00 76.55  ?  164 GLY A N   1 
ATOM   29   C CA  . GLY A 1 175 ? 124.946 131.078 106.250 1.00 76.55  ?  164 GLY A CA  1 
ATOM   30   C C   . GLY A 1 175 ? 124.758 131.913 105.002 1.00 76.55  ?  164 GLY A C   1 
ATOM   31   O O   . GLY A 1 175 ? 125.190 131.565 103.904 1.00 76.55  ?  164 GLY A O   1 
ATOM   32   N N   . LEU A 1 176 ? 124.091 133.046 105.188 1.00 66.90  ?  165 LEU A N   1 
ATOM   33   C CA  . LEU A 1 176 ? 123.839 133.961 104.089 1.00 66.90  ?  165 LEU A CA  1 
ATOM   34   C C   . LEU A 1 176 ? 125.111 134.705 103.697 1.00 66.90  ?  165 LEU A C   1 
ATOM   35   O O   . LEU A 1 176 ? 126.028 134.892 104.498 1.00 66.90  ?  165 LEU A O   1 
ATOM   36   C CB  . LEU A 1 176 ? 122.755 134.965 104.469 1.00 66.90  ?  165 LEU A CB  1 
ATOM   37   C CG  . LEU A 1 176 ? 121.431 134.380 104.946 1.00 66.90  ?  165 LEU A CG  1 
ATOM   38   C CD1 . LEU A 1 176 ? 120.646 135.414 105.721 1.00 66.90  ?  165 LEU A CD1 1 
ATOM   39   C CD2 . LEU A 1 176 ? 120.635 133.886 103.759 1.00 66.90  ?  165 LEU A CD2 1 
ATOM   40   N N   . SER A 1 177 ? 125.156 135.127 102.441 1.00 68.09  ?  166 SER A N   1 
ATOM   41   C CA  . SER A 1 177 ? 126.210 135.993 101.947 1.00 68.09  ?  166 SER A CA  1 
ATOM   42   C C   . SER A 1 177 ? 125.797 137.439 102.194 1.00 68.09  ?  166 SER A C   1 
ATOM   43   O O   . SER A 1 177 ? 124.758 137.708 102.796 1.00 68.09  ?  166 SER A O   1 
ATOM   44   C CB  . SER A 1 177 ? 126.483 135.711 100.470 1.00 68.09  ?  166 SER A CB  1 
ATOM   45   O OG  . SER A 1 177 ? 127.499 136.559 99.969  1.00 68.09  ?  166 SER A OG  1 
ATOM   46   N N   . LYS A 1 178 ? 126.610 138.387 101.728 1.00 67.68  ?  167 LYS A N   1 
ATOM   47   C CA  . LYS A 1 178 ? 126.340 139.791 102.022 1.00 67.68  ?  167 LYS A CA  1 
ATOM   48   C C   . LYS A 1 178 ? 125.147 140.312 101.227 1.00 67.68  ?  167 LYS A C   1 
ATOM   49   O O   . LYS A 1 178 ? 124.373 141.136 101.729 1.00 67.68  ?  167 LYS A O   1 
ATOM   50   C CB  . LYS A 1 178 ? 127.583 140.632 101.741 1.00 67.68  ?  167 LYS A CB  1 
ATOM   51   C CG  . LYS A 1 178 ? 127.466 142.066 102.207 1.00 67.68  ?  167 LYS A CG  1 
ATOM   52   C CD  . LYS A 1 178 ? 128.631 142.904 101.747 1.00 67.68  ?  167 LYS A CD  1 
ATOM   53   C CE  . LYS A 1 178 ? 128.392 144.364 102.068 1.00 67.68  ?  167 LYS A CE  1 
ATOM   54   N NZ  . LYS A 1 178 ? 129.481 145.229 101.544 1.00 67.68  1  167 LYS A NZ  1 
ATOM   55   N N   . GLU A 1 179 ? 124.959 139.814 100.004 1.00 72.89  ?  168 GLU A N   1 
ATOM   56   C CA  . GLU A 1 179 ? 123.914 140.345 99.133  1.00 72.89  ?  168 GLU A CA  1 
ATOM   57   C C   . GLU A 1 179 ? 122.528 139.906 99.592  1.00 72.89  ?  168 GLU A C   1 
ATOM   58   O O   . GLU A 1 179 ? 121.612 140.734 99.692  1.00 72.89  ?  168 GLU A O   1 
ATOM   59   C CB  . GLU A 1 179 ? 124.148 139.930 97.674  1.00 72.89  ?  168 GLU A CB  1 
ATOM   60   C CG  . GLU A 1 179 ? 125.507 140.301 97.044  1.00 72.89  ?  168 GLU A CG  1 
ATOM   61   C CD  . GLU A 1 179 ? 126.666 139.419 97.482  1.00 72.89  ?  168 GLU A CD  1 
ATOM   62   O OE1 . GLU A 1 179 ? 127.832 139.846 97.350  1.00 72.89  ?  168 GLU A OE1 1 
ATOM   63   O OE2 . GLU A 1 179 ? 126.404 138.301 97.969  1.00 72.89  -1 168 GLU A OE2 1 
ATOM   64   N N   . GLU A 1 180 ? 122.356 138.619 99.898  1.00 72.17  ?  169 GLU A N   1 
ATOM   65   C CA  . GLU A 1 180 ? 121.041 138.155 100.326 1.00 72.17  ?  169 GLU A CA  1 
ATOM   66   C C   . GLU A 1 180 ? 120.714 138.629 101.737 1.00 72.17  ?  169 GLU A C   1 
ATOM   67   O O   . GLU A 1 180 ? 119.542 138.858 102.056 1.00 72.17  ?  169 GLU A O   1 
ATOM   68   C CB  . GLU A 1 180 ? 120.942 136.635 100.223 1.00 72.17  ?  169 GLU A CB  1 
ATOM   69   C CG  . GLU A 1 180 ? 122.072 135.868 100.856 1.00 72.17  ?  169 GLU A CG  1 
ATOM   70   C CD  . GLU A 1 180 ? 123.004 135.274 99.826  1.00 72.17  ?  169 GLU A CD  1 
ATOM   71   O OE1 . GLU A 1 180 ? 123.157 135.880 98.746  1.00 72.17  ?  169 GLU A OE1 1 
ATOM   72   O OE2 . GLU A 1 180 ? 123.566 134.190 100.086 1.00 72.17  -1 169 GLU A OE2 1 
ATOM   73   N N   . LEU A 1 181 ? 121.734 138.809 102.585 1.00 67.31  ?  170 LEU A N   1 
ATOM   74   C CA  . LEU A 1 181 ? 121.501 139.415 103.893 1.00 67.31  ?  170 LEU A CA  1 
ATOM   75   C C   . LEU A 1 181 ? 121.070 140.866 103.756 1.00 67.31  ?  170 LEU A C   1 
ATOM   76   O O   . LEU A 1 181 ? 120.115 141.297 104.411 1.00 67.31  ?  170 LEU A O   1 
ATOM   77   C CB  . LEU A 1 181 ? 122.750 139.325 104.768 1.00 67.31  ?  170 LEU A CB  1 
ATOM   78   C CG  . LEU A 1 181 ? 122.617 140.022 106.123 1.00 67.31  ?  170 LEU A CG  1 
ATOM   79   C CD1 . LEU A 1 181 ? 121.918 139.119 107.115 1.00 67.31  ?  170 LEU A CD1 1 
ATOM   80   C CD2 . LEU A 1 181 ? 123.952 140.481 106.656 1.00 67.31  ?  170 LEU A CD2 1 
ATOM   81   N N   . LEU A 1 182 ? 121.741 141.629 102.889 1.00 69.22  ?  171 LEU A N   1 
ATOM   82   C CA  . LEU A 1 182 ? 121.352 143.014 102.665 1.00 69.22  ?  171 LEU A CA  1 
ATOM   83   C C   . LEU A 1 182 ? 119.993 143.137 101.991 1.00 69.22  ?  171 LEU A C   1 
ATOM   84   O O   . LEU A 1 182 ? 119.347 144.182 102.119 1.00 69.22  ?  171 LEU A O   1 
ATOM   85   C CB  . LEU A 1 182 ? 122.412 143.731 101.833 1.00 69.22  ?  171 LEU A CB  1 
ATOM   86   C CG  . LEU A 1 182 ? 123.592 144.305 102.617 1.00 69.22  ?  171 LEU A CG  1 
ATOM   87   C CD1 . LEU A 1 182 ? 124.550 145.029 101.689 1.00 69.22  ?  171 LEU A CD1 1 
ATOM   88   C CD2 . LEU A 1 182 ? 123.108 145.228 103.720 1.00 69.22  ?  171 LEU A CD2 1 
ATOM   89   N N   . LYS A 1 183 ? 119.538 142.100 101.287 1.00 72.83  ?  172 LYS A N   1 
ATOM   90   C CA  . LYS A 1 183 ? 118.206 142.152 100.704 1.00 72.83  ?  172 LYS A CA  1 
ATOM   91   C C   . LYS A 1 183 ? 117.110 141.595 101.610 1.00 72.83  ?  172 LYS A C   1 
ATOM   92   O O   . LYS A 1 183 ? 115.935 141.883 101.363 1.00 72.83  ?  172 LYS A O   1 
ATOM   93   C CB  . LYS A 1 183 ? 118.180 141.420 99.356  1.00 72.83  ?  172 LYS A CB  1 
ATOM   94   C CG  . LYS A 1 183 ? 117.826 139.949 99.420  1.00 72.83  ?  172 LYS A CG  1 
ATOM   95   C CD  . LYS A 1 183 ? 117.694 139.367 98.025  1.00 72.83  ?  172 LYS A CD  1 
ATOM   96   C CE  . LYS A 1 183 ? 119.042 139.296 97.333  1.00 72.83  ?  172 LYS A CE  1 
ATOM   97   N NZ  . LYS A 1 183 ? 118.982 138.499 96.080  1.00 72.83  1  172 LYS A NZ  1 
ATOM   98   N N   . VAL A 1 184 ? 117.438 140.821 102.650 1.00 70.03  ?  173 VAL A N   1 
ATOM   99   C CA  . VAL A 1 184 ? 116.370 140.300 103.503 1.00 70.03  ?  173 VAL A CA  1 
ATOM   100  C C   . VAL A 1 184 ? 116.325 141.059 104.829 1.00 70.03  ?  173 VAL A C   1 
ATOM   101  O O   . VAL A 1 184 ? 115.260 141.185 105.441 1.00 70.03  ?  173 VAL A O   1 
ATOM   102  C CB  . VAL A 1 184 ? 116.494 138.771 103.714 1.00 70.03  ?  173 VAL A CB  1 
ATOM   103  C CG1 . VAL A 1 184 ? 117.631 138.383 104.653 1.00 70.03  ?  173 VAL A CG1 1 
ATOM   104  C CG2 . VAL A 1 184 ? 115.175 138.173 104.187 1.00 70.03  ?  173 VAL A CG2 1 
ATOM   105  N N   . ALA A 1 185 ? 117.456 141.596 105.275 1.00 71.56  ?  174 ALA A N   1 
ATOM   106  C CA  . ALA A 1 185 ? 117.493 142.364 106.522 1.00 71.56  ?  174 ALA A CA  1 
ATOM   107  C C   . ALA A 1 185 ? 117.360 143.855 106.256 1.00 71.56  ?  174 ALA A C   1 
ATOM   108  O O   . ALA A 1 185 ? 118.149 144.667 106.731 1.00 71.56  ?  174 ALA A O   1 
ATOM   109  C CB  . ALA A 1 185 ? 118.767 142.059 107.297 1.00 71.56  ?  174 ALA A CB  1 
ATOM   110  N N   . GLY A 1 186 ? 116.345 144.229 105.491 1.00 72.49  ?  175 GLY A N   1 
ATOM   111  C CA  . GLY A 1 186 ? 116.042 145.623 105.257 1.00 72.49  ?  175 GLY A CA  1 
ATOM   112  C C   . GLY A 1 186 ? 114.545 145.816 105.210 1.00 72.49  ?  175 GLY A C   1 
ATOM   113  O O   . GLY A 1 186 ? 114.052 146.924 104.989 1.00 72.49  ?  175 GLY A O   1 
ATOM   114  N N   . SER A 1 187 ? 113.817 144.725 105.416 1.00 74.02  ?  176 SER A N   1 
ATOM   115  C CA  . SER A 1 187 ? 112.368 144.776 105.359 1.00 74.02  ?  176 SER A CA  1 
ATOM   116  C C   . SER A 1 187 ? 111.814 145.420 106.627 1.00 74.02  ?  176 SER A C   1 
ATOM   117  O O   . SER A 1 187 ? 112.385 145.254 107.708 1.00 74.02  ?  176 SER A O   1 
ATOM   118  C CB  . SER A 1 187 ? 111.790 143.374 105.200 1.00 74.02  ?  176 SER A CB  1 
ATOM   119  O OG  . SER A 1 187 ? 112.000 142.605 106.368 1.00 74.02  ?  176 SER A OG  1 
ATOM   120  N N   . PRO A 1 188 ? 110.715 146.171 106.525 1.00 74.25  ?  177 PRO A N   1 
ATOM   121  C CA  . PRO A 1 188 ? 110.049 146.667 107.735 1.00 74.25  ?  177 PRO A CA  1 
ATOM   122  C C   . PRO A 1 188 ? 109.421 145.527 108.512 1.00 74.25  ?  177 PRO A C   1 
ATOM   123  O O   . PRO A 1 188 ? 108.452 144.910 108.059 1.00 74.25  ?  177 PRO A O   1 
ATOM   124  C CB  . PRO A 1 188 ? 108.989 147.632 107.190 1.00 74.25  ?  177 PRO A CB  1 
ATOM   125  C CG  . PRO A 1 188 ? 109.402 147.915 105.781 1.00 74.25  ?  177 PRO A CG  1 
ATOM   126  C CD  . PRO A 1 188 ? 110.071 146.675 105.303 1.00 74.25  ?  177 PRO A CD  1 
ATOM   127  N N   . GLY A 1 189 ? 109.972 145.241 109.682 1.00 69.58  ?  178 GLY A N   1 
ATOM   128  C CA  . GLY A 1 189 ? 109.616 144.049 110.419 1.00 69.58  ?  178 GLY A CA  1 
ATOM   129  C C   . GLY A 1 189 ? 110.853 143.449 111.044 1.00 69.58  ?  178 GLY A C   1 
ATOM   130  O O   . GLY A 1 189 ? 110.791 142.818 112.103 1.00 69.58  ?  178 GLY A O   1 
ATOM   131  N N   . TRP A 1 190 ? 111.989 143.644 110.384 1.00 66.37  ?  179 TRP A N   1 
ATOM   132  C CA  . TRP A 1 190 ? 113.291 143.367 110.969 1.00 66.37  ?  179 TRP A CA  1 
ATOM   133  C C   . TRP A 1 190 ? 113.957 144.625 111.505 1.00 66.37  ?  179 TRP A C   1 
ATOM   134  O O   . TRP A 1 190 ? 114.589 144.582 112.566 1.00 66.37  ?  179 TRP A O   1 
ATOM   135  C CB  . TRP A 1 190 ? 114.205 142.694 109.942 1.00 66.37  ?  179 TRP A CB  1 
ATOM   136  C CG  . TRP A 1 190 ? 113.985 141.218 109.823 1.00 66.37  ?  179 TRP A CG  1 
ATOM   137  C CD1 . TRP A 1 190 ? 113.522 140.545 108.733 1.00 66.37  ?  179 TRP A CD1 1 
ATOM   138  C CD2 . TRP A 1 190 ? 114.210 140.231 110.836 1.00 66.37  ?  179 TRP A CD2 1 
ATOM   139  N NE1 . TRP A 1 190 ? 113.449 139.203 109.001 1.00 66.37  ?  179 TRP A NE1 1 
ATOM   140  C CE2 . TRP A 1 190 ? 113.865 138.985 110.286 1.00 66.37  ?  179 TRP A CE2 1 
ATOM   141  C CE3 . TRP A 1 190 ? 114.677 140.281 112.154 1.00 66.37  ?  179 TRP A CE3 1 
ATOM   142  C CZ2 . TRP A 1 190 ? 113.968 137.801 111.005 1.00 66.37  ?  179 TRP A CZ2 1 
ATOM   143  C CZ3 . TRP A 1 190 ? 114.775 139.106 112.865 1.00 66.37  ?  179 TRP A CZ3 1 
ATOM   144  C CH2 . TRP A 1 190 ? 114.423 137.882 112.290 1.00 66.37  ?  179 TRP A CH2 1 
ATOM   145  N N   . VAL A 1 191 ? 113.793 145.744 110.795 1.00 67.17  ?  180 VAL A N   1 
ATOM   146  C CA  . VAL A 1 191 ? 114.307 147.038 111.242 1.00 67.17  ?  180 VAL A CA  1 
ATOM   147  C C   . VAL A 1 191 ? 113.652 147.460 112.555 1.00 67.17  ?  180 VAL A C   1 
ATOM   148  O O   . VAL A 1 191 ? 114.330 147.911 113.491 1.00 67.17  ?  180 VAL A O   1 
ATOM   149  C CB  . VAL A 1 191 ? 114.093 148.080 110.127 1.00 67.17  ?  180 VAL A CB  1 
ATOM   150  C CG1 . VAL A 1 191 ? 114.305 149.484 110.632 1.00 67.17  ?  180 VAL A CG1 1 
ATOM   151  C CG2 . VAL A 1 191 ? 115.014 147.798 108.958 1.00 67.17  ?  180 VAL A CG2 1 
ATOM   152  N N   . ARG A 1 192 ? 112.331 147.290 112.654 1.00 67.43  ?  181 ARG A N   1 
ATOM   153  C CA  . ARG A 1 192 ? 111.622 147.616 113.886 1.00 67.43  ?  181 ARG A CA  1 
ATOM   154  C C   . ARG A 1 192 ? 112.044 146.707 115.032 1.00 67.43  ?  181 ARG A C   1 
ATOM   155  O O   . ARG A 1 192 ? 112.112 147.152 116.181 1.00 67.43  ?  181 ARG A O   1 
ATOM   156  C CB  . ARG A 1 192 ? 110.117 147.519 113.662 1.00 67.43  ?  181 ARG A CB  1 
ATOM   157  C CG  . ARG A 1 192 ? 109.528 148.661 112.870 1.00 67.43  ?  181 ARG A CG  1 
ATOM   158  C CD  . ARG A 1 192 ? 108.165 148.272 112.337 1.00 67.43  ?  181 ARG A CD  1 
ATOM   159  N NE  . ARG A 1 192 ? 107.605 149.279 111.445 1.00 67.43  ?  181 ARG A NE  1 
ATOM   160  C CZ  . ARG A 1 192 ? 106.664 149.028 110.543 1.00 67.43  ?  181 ARG A CZ  1 
ATOM   161  N NH1 . ARG A 1 192 ? 106.209 150.004 109.772 1.00 67.43  1  181 ARG A NH1 1 
ATOM   162  N NH2 . ARG A 1 192 ? 106.185 147.799 110.408 1.00 67.43  ?  181 ARG A NH2 1 
ATOM   163  N N   . THR A 1 193 ? 112.366 145.446 114.730 1.00 65.24  ?  182 THR A N   1 
ATOM   164  C CA  . THR A 1 193 ? 112.857 144.530 115.757 1.00 65.24  ?  182 THR A CA  1 
ATOM   165  C C   . THR A 1 193 ? 114.219 144.962 116.281 1.00 65.24  ?  182 THR A C   1 
ATOM   166  O O   . THR A 1 193 ? 114.466 144.917 117.493 1.00 65.24  ?  182 THR A O   1 
ATOM   167  C CB  . THR A 1 193 ? 112.935 143.110 115.205 1.00 65.24  ?  182 THR A CB  1 
ATOM   168  O OG1 . THR A 1 193 ? 111.752 142.831 114.451 1.00 65.24  ?  182 THR A OG1 1 
ATOM   169  C CG2 . THR A 1 193 ? 113.049 142.110 116.339 1.00 65.24  ?  182 THR A CG2 1 
ATOM   170  N N   . ARG A 1 194 ? 115.102 145.420 115.388 1.00 66.63  ?  183 ARG A N   1 
ATOM   171  C CA  . ARG A 1 194 ? 116.434 145.838 115.820 1.00 66.63  ?  183 ARG A CA  1 
ATOM   172  C C   . ARG A 1 194 ? 116.381 147.120 116.649 1.00 66.63  ?  183 ARG A C   1 
ATOM   173  O O   . ARG A 1 194 ? 117.034 147.215 117.700 1.00 66.63  ?  183 ARG A O   1 
ATOM   174  C CB  . ARG A 1 194 ? 117.346 145.994 114.605 1.00 66.63  ?  183 ARG A CB  1 
ATOM   175  C CG  . ARG A 1 194 ? 117.554 144.687 113.867 1.00 66.63  ?  183 ARG A CG  1 
ATOM   176  C CD  . ARG A 1 194 ? 118.841 144.664 113.081 1.00 66.63  ?  183 ARG A CD  1 
ATOM   177  N NE  . ARG A 1 194 ? 118.779 145.529 111.911 1.00 66.63  ?  183 ARG A NE  1 
ATOM   178  C CZ  . ARG A 1 194 ? 118.299 145.154 110.732 1.00 66.63  ?  183 ARG A CZ  1 
ATOM   179  N NH1 . ARG A 1 194 ? 118.280 146.010 109.724 1.00 66.63  1  183 ARG A NH1 1 
ATOM   180  N NH2 . ARG A 1 194 ? 117.834 143.926 110.561 1.00 66.63  ?  183 ARG A NH2 1 
ATOM   181  N N   . TRP A 1 195 ? 115.575 148.099 116.220 1.00 69.70  ?  184 TRP A N   1 
ATOM   182  C CA  . TRP A 1 195 ? 115.413 149.314 117.020 1.00 69.70  ?  184 TRP A CA  1 
ATOM   183  C C   . TRP A 1 195 ? 114.695 149.047 118.343 1.00 69.70  ?  184 TRP A C   1 
ATOM   184  O O   . TRP A 1 195 ? 115.037 149.661 119.364 1.00 69.70  ?  184 TRP A O   1 
ATOM   185  C CB  . TRP A 1 195 ? 114.702 150.397 116.208 1.00 69.70  ?  184 TRP A CB  1 
ATOM   186  C CG  . TRP A 1 195 ? 115.645 151.371 115.531 1.00 69.70  ?  184 TRP A CG  1 
ATOM   187  C CD1 . TRP A 1 195 ? 115.979 152.618 115.984 1.00 69.70  ?  184 TRP A CD1 1 
ATOM   188  C CD2 . TRP A 1 195 ? 116.414 151.168 114.334 1.00 69.70  ?  184 TRP A CD2 1 
ATOM   189  N NE1 . TRP A 1 195 ? 116.874 153.213 115.131 1.00 69.70  ?  184 TRP A NE1 1 
ATOM   190  C CE2 . TRP A 1 195 ? 117.161 152.343 114.114 1.00 69.70  ?  184 TRP A CE2 1 
ATOM   191  C CE3 . TRP A 1 195 ? 116.541 150.115 113.427 1.00 69.70  ?  184 TRP A CE3 1 
ATOM   192  C CZ2 . TRP A 1 195 ? 118.011 152.494 113.023 1.00 69.70  ?  184 TRP A CZ2 1 
ATOM   193  C CZ3 . TRP A 1 195 ? 117.388 150.267 112.344 1.00 69.70  ?  184 TRP A CZ3 1 
ATOM   194  C CH2 . TRP A 1 195 ? 118.111 151.448 112.150 1.00 69.70  ?  184 TRP A CH2 1 
ATOM   195  N N   . ALA A 1 196 ? 113.738 148.112 118.363 1.00 62.70  ?  185 ALA A N   1 
ATOM   196  C CA  . ALA A 1 196 ? 113.053 147.777 119.607 1.00 62.70  ?  185 ALA A CA  1 
ATOM   197  C C   . ALA A 1 196 ? 113.993 147.111 120.598 1.00 62.70  ?  185 ALA A C   1 
ATOM   198  O O   . ALA A 1 196 ? 113.956 147.418 121.796 1.00 62.70  ?  185 ALA A O   1 
ATOM   199  C CB  . ALA A 1 196 ? 111.858 146.871 119.323 1.00 62.70  ?  185 ALA A CB  1 
ATOM   200  N N   . LEU A 1 197 ? 114.865 146.223 120.114 1.00 61.42  ?  186 LEU A N   1 
ATOM   201  C CA  . LEU A 1 197 ? 115.818 145.574 121.005 1.00 61.42  ?  186 LEU A CA  1 
ATOM   202  C C   . LEU A 1 197 ? 116.861 146.559 121.520 1.00 61.42  ?  186 LEU A C   1 
ATOM   203  O O   . LEU A 1 197 ? 117.279 146.466 122.680 1.00 61.42  ?  186 LEU A O   1 
ATOM   204  C CB  . LEU A 1 197 ? 116.483 144.404 120.291 1.00 61.42  ?  186 LEU A CB  1 
ATOM   205  C CG  . LEU A 1 197 ? 115.608 143.163 120.139 1.00 61.42  ?  186 LEU A CG  1 
ATOM   206  C CD1 . LEU A 1 197 ? 116.331 142.116 119.320 1.00 61.42  ?  186 LEU A CD1 1 
ATOM   207  C CD2 . LEU A 1 197 ? 115.223 142.609 121.495 1.00 61.42  ?  186 LEU A CD2 1 
ATOM   208  N N   . LEU A 1 198 ? 117.260 147.530 120.690 1.00 61.86  ?  187 LEU A N   1 
ATOM   209  C CA  . LEU A 1 198 ? 118.213 148.545 121.143 1.00 61.86  ?  187 LEU A CA  1 
ATOM   210  C C   . LEU A 1 198 ? 117.620 149.431 122.239 1.00 61.86  ?  187 LEU A C   1 
ATOM   211  O O   . LEU A 1 198 ? 118.260 149.666 123.277 1.00 61.86  ?  187 LEU A O   1 
ATOM   212  C CB  . LEU A 1 198 ? 118.674 149.390 119.958 1.00 61.86  ?  187 LEU A CB  1 
ATOM   213  C CG  . LEU A 1 198 ? 119.621 150.553 120.255 1.00 61.86  ?  187 LEU A CG  1 
ATOM   214  C CD1 . LEU A 1 198 ? 120.994 150.054 120.660 1.00 61.86  ?  187 LEU A CD1 1 
ATOM   215  C CD2 . LEU A 1 198 ? 119.718 151.470 119.051 1.00 61.86  ?  187 LEU A CD2 1 
ATOM   216  N N   . LEU A 1 199 ? 116.385 149.912 122.038 1.00 61.26  ?  188 LEU A N   1 
ATOM   217  C CA  . LEU A 1 199 ? 115.750 150.748 123.058 1.00 61.26  ?  188 LEU A CA  1 
ATOM   218  C C   . LEU A 1 199 ? 115.427 149.963 124.326 1.00 61.26  ?  188 LEU A C   1 
ATOM   219  O O   . LEU A 1 199 ? 115.537 150.509 125.433 1.00 61.26  ?  188 LEU A O   1 
ATOM   220  C CB  . LEU A 1 199 ? 114.483 151.395 122.505 1.00 61.26  ?  188 LEU A CB  1 
ATOM   221  C CG  . LEU A 1 199 ? 114.674 152.315 121.300 1.00 61.26  ?  188 LEU A CG  1 
ATOM   222  C CD1 . LEU A 1 199 ? 113.354 152.940 120.889 1.00 61.26  ?  188 LEU A CD1 1 
ATOM   223  C CD2 . LEU A 1 199 ? 115.712 153.388 121.587 1.00 61.26  ?  188 LEU A CD2 1 
ATOM   224  N N   . LEU A 1 200 ? 115.068 148.683 124.189 1.00 59.62  ?  189 LEU A N   1 
ATOM   225  C CA  . LEU A 1 200 ? 114.804 147.849 125.356 1.00 59.62  ?  189 LEU A CA  1 
ATOM   226  C C   . LEU A 1 200 ? 116.075 147.596 126.156 1.00 59.62  ?  189 LEU A C   1 
ATOM   227  O O   . LEU A 1 200 ? 116.046 147.617 127.395 1.00 59.62  ?  189 LEU A O   1 
ATOM   228  C CB  . LEU A 1 200 ? 114.172 146.534 124.907 1.00 59.62  ?  189 LEU A CB  1 
ATOM   229  C CG  . LEU A 1 200 ? 113.456 145.655 125.926 1.00 59.62  ?  189 LEU A CG  1 
ATOM   230  C CD1 . LEU A 1 200 ? 112.186 145.118 125.304 1.00 59.62  ?  189 LEU A CD1 1 
ATOM   231  C CD2 . LEU A 1 200 ? 114.346 144.510 126.364 1.00 59.62  ?  189 LEU A CD2 1 
ATOM   232  N N   . PHE A 1 201 ? 117.202 147.387 125.464 1.00 58.45  ?  190 PHE A N   1 
ATOM   233  C CA  . PHE A 1 201 ? 118.482 147.214 126.142 1.00 58.45  ?  190 PHE A CA  1 
ATOM   234  C C   . PHE A 1 201 ? 118.889 148.475 126.893 1.00 58.45  ?  190 PHE A C   1 
ATOM   235  O O   . PHE A 1 201 ? 119.374 148.397 128.030 1.00 58.45  ?  190 PHE A O   1 
ATOM   236  C CB  . PHE A 1 201 ? 119.559 146.820 125.126 1.00 58.45  ?  190 PHE A CB  1 
ATOM   237  C CG  . PHE A 1 201 ? 120.965 147.134 125.565 1.00 58.45  ?  190 PHE A CG  1 
ATOM   238  C CD1 . PHE A 1 201 ? 121.594 146.356 126.520 1.00 58.45  ?  190 PHE A CD1 1 
ATOM   239  C CD2 . PHE A 1 201 ? 121.664 148.193 125.005 1.00 58.45  ?  190 PHE A CD2 1 
ATOM   240  C CE1 . PHE A 1 201 ? 122.883 146.639 126.924 1.00 58.45  ?  190 PHE A CE1 1 
ATOM   241  C CE2 . PHE A 1 201 ? 122.952 148.481 125.408 1.00 58.45  ?  190 PHE A CE2 1 
ATOM   242  C CZ  . PHE A 1 201 ? 123.562 147.700 126.364 1.00 58.45  ?  190 PHE A CZ  1 
ATOM   243  N N   . TRP A 1 202 ? 118.684 149.649 126.286 1.00 57.59  ?  191 TRP A N   1 
ATOM   244  C CA  . TRP A 1 202 ? 119.103 150.869 126.973 1.00 57.59  ?  191 TRP A CA  1 
ATOM   245  C C   . TRP A 1 202 ? 118.198 151.207 128.154 1.00 57.59  ?  191 TRP A C   1 
ATOM   246  O O   . TRP A 1 202 ? 118.689 151.697 129.182 1.00 57.59  ?  191 TRP A O   1 
ATOM   247  C CB  . TRP A 1 202 ? 119.182 152.046 126.003 1.00 57.59  ?  191 TRP A CB  1 
ATOM   248  C CG  . TRP A 1 202 ? 120.495 152.124 125.263 1.00 57.59  ?  191 TRP A CG  1 
ATOM   249  C CD1 . TRP A 1 202 ? 120.668 152.068 123.915 1.00 57.59  ?  191 TRP A CD1 1 
ATOM   250  C CD2 . TRP A 1 202 ? 121.810 152.266 125.828 1.00 57.59  ?  191 TRP A CD2 1 
ATOM   251  N NE1 . TRP A 1 202 ? 121.999 152.167 123.601 1.00 57.59  ?  191 TRP A NE1 1 
ATOM   252  C CE2 . TRP A 1 202 ? 122.721 152.287 124.758 1.00 57.59  ?  191 TRP A CE2 1 
ATOM   253  C CE3 . TRP A 1 202 ? 122.304 152.381 127.132 1.00 57.59  ?  191 TRP A CE3 1 
ATOM   254  C CZ2 . TRP A 1 202 ? 124.092 152.418 124.949 1.00 57.59  ?  191 TRP A CZ2 1 
ATOM   255  C CZ3 . TRP A 1 202 ? 123.665 152.505 127.317 1.00 57.59  ?  191 TRP A CZ3 1 
ATOM   256  C CH2 . TRP A 1 202 ? 124.542 152.525 126.234 1.00 57.59  ?  191 TRP A CH2 1 
ATOM   257  N N   . LEU A 1 203 ? 116.894 150.923 128.059 1.00 58.85  ?  192 LEU A N   1 
ATOM   258  C CA  . LEU A 1 203 ? 116.051 151.171 129.225 1.00 58.85  ?  192 LEU A CA  1 
ATOM   259  C C   . LEU A 1 203 ? 116.308 150.149 130.327 1.00 58.85  ?  192 LEU A C   1 
ATOM   260  O O   . LEU A 1 203 ? 116.197 150.489 131.508 1.00 58.85  ?  192 LEU A O   1 
ATOM   261  C CB  . LEU A 1 203 ? 114.568 151.223 128.837 1.00 58.85  ?  192 LEU A CB  1 
ATOM   262  C CG  . LEU A 1 203 ? 113.734 150.081 128.253 1.00 58.85  ?  192 LEU A CG  1 
ATOM   263  C CD1 . LEU A 1 203 ? 113.100 149.205 129.326 1.00 58.85  ?  192 LEU A CD1 1 
ATOM   264  C CD2 . LEU A 1 203 ? 112.656 150.657 127.347 1.00 58.85  ?  192 LEU A CD2 1 
ATOM   265  N N   . GLY A 1 204 ? 116.708 148.923 129.978 1.00 58.42  ?  193 GLY A N   1 
ATOM   266  C CA  . GLY A 1 204 ? 117.122 147.977 131.006 1.00 58.42  ?  193 GLY A CA  1 
ATOM   267  C C   . GLY A 1 204 ? 118.413 148.379 131.700 1.00 58.42  ?  193 GLY A C   1 
ATOM   268  O O   . GLY A 1 204 ? 118.560 148.196 132.915 1.00 58.42  ?  193 GLY A O   1 
ATOM   269  N N   . TRP A 1 205 ? 119.358 148.944 130.942 1.00 56.24  ?  194 TRP A N   1 
ATOM   270  C CA  . TRP A 1 205 ? 120.602 149.444 131.526 1.00 56.24  ?  194 TRP A CA  1 
ATOM   271  C C   . TRP A 1 205 ? 120.350 150.613 132.474 1.00 56.24  ?  194 TRP A C   1 
ATOM   272  O O   . TRP A 1 205 ? 120.904 150.657 133.585 1.00 56.24  ?  194 TRP A O   1 
ATOM   273  C CB  . TRP A 1 205 ? 121.556 149.854 130.407 1.00 56.24  ?  194 TRP A CB  1 
ATOM   274  C CG  . TRP A 1 205 ? 122.938 150.171 130.849 1.00 56.24  ?  194 TRP A CG  1 
ATOM   275  C CD1 . TRP A 1 205 ? 123.914 149.285 131.180 1.00 56.24  ?  194 TRP A CD1 1 
ATOM   276  C CD2 . TRP A 1 205 ? 123.510 151.473 130.993 1.00 56.24  ?  194 TRP A CD2 1 
ATOM   277  N NE1 . TRP A 1 205 ? 125.059 149.952 131.526 1.00 56.24  ?  194 TRP A NE1 1 
ATOM   278  C CE2 . TRP A 1 205 ? 124.837 151.298 131.422 1.00 56.24  ?  194 TRP A CE2 1 
ATOM   279  C CE3 . TRP A 1 205 ? 123.028 152.769 130.805 1.00 56.24  ?  194 TRP A CE3 1 
ATOM   280  C CZ2 . TRP A 1 205 ? 125.688 152.369 131.662 1.00 56.24  ?  194 TRP A CZ2 1 
ATOM   281  C CZ3 . TRP A 1 205 ? 123.873 153.830 131.047 1.00 56.24  ?  194 TRP A CZ3 1 
ATOM   282  C CH2 . TRP A 1 205 ? 125.188 153.625 131.469 1.00 56.24  ?  194 TRP A CH2 1 
ATOM   283  N N   . LEU A 1 206 ? 119.501 151.561 132.059 1.00 58.43  ?  195 LEU A N   1 
ATOM   284  C CA  . LEU A 1 206 ? 119.134 152.661 132.946 1.00 58.43  ?  195 LEU A CA  1 
ATOM   285  C C   . LEU A 1 206 ? 118.350 152.176 134.159 1.00 58.43  ?  195 LEU A C   1 
ATOM   286  O O   . LEU A 1 206 ? 118.498 152.733 135.254 1.00 58.43  ?  195 LEU A O   1 
ATOM   287  C CB  . LEU A 1 206 ? 118.328 153.709 132.184 1.00 58.43  ?  195 LEU A CB  1 
ATOM   288  C CG  . LEU A 1 206 ? 119.156 154.753 131.440 1.00 58.43  ?  195 LEU A CG  1 
ATOM   289  C CD1 . LEU A 1 206 ? 118.249 155.748 130.747 1.00 58.43  ?  195 LEU A CD1 1 
ATOM   290  C CD2 . LEU A 1 206 ? 120.101 155.458 132.390 1.00 58.43  ?  195 LEU A CD2 1 
ATOM   291  N N   . GLY A 1 207 ? 117.546 151.124 133.996 1.00 58.93  ?  196 GLY A N   1 
ATOM   292  C CA  . GLY A 1 207 ? 116.816 150.579 135.126 1.00 58.93  ?  196 GLY A CA  1 
ATOM   293  C C   . GLY A 1 207 ? 117.716 149.929 136.157 1.00 58.93  ?  196 GLY A C   1 
ATOM   294  O O   . GLY A 1 207 ? 117.501 150.084 137.362 1.00 58.93  ?  196 GLY A O   1 
ATOM   295  N N   . MET A 1 208 ? 118.749 149.212 135.707 1.00 60.10  ?  197 MET A N   1 
ATOM   296  C CA  . MET A 1 208 ? 119.649 148.603 136.683 1.00 60.10  ?  197 MET A CA  1 
ATOM   297  C C   . MET A 1 208 ? 120.559 149.642 137.336 1.00 60.10  ?  197 MET A C   1 
ATOM   298  O O   . MET A 1 208 ? 120.908 149.495 138.517 1.00 60.10  ?  197 MET A O   1 
ATOM   299  C CB  . MET A 1 208 ? 120.450 147.460 136.047 1.00 60.10  ?  197 MET A CB  1 
ATOM   300  C CG  . MET A 1 208 ? 121.576 147.853 135.121 1.00 60.10  ?  197 MET A CG  1 
ATOM   301  S SD  . MET A 1 208 ? 122.681 146.477 134.777 1.00 60.10  ?  197 MET A SD  1 
ATOM   302  C CE  . MET A 1 208 ? 121.547 145.293 134.068 1.00 60.10  ?  197 MET A CE  1 
ATOM   303  N N   . LEU A 1 209 ? 120.891 150.731 136.626 1.00 59.16  ?  198 LEU A N   1 
ATOM   304  C CA  . LEU A 1 209 ? 121.618 151.821 137.279 1.00 59.16  ?  198 LEU A CA  1 
ATOM   305  C C   . LEU A 1 209 ? 120.761 152.518 138.332 1.00 59.16  ?  198 LEU A C   1 
ATOM   306  O O   . LEU A 1 209 ? 121.253 152.849 139.420 1.00 59.16  ?  198 LEU A O   1 
ATOM   307  C CB  . LEU A 1 209 ? 122.109 152.838 136.254 1.00 59.16  ?  198 LEU A CB  1 
ATOM   308  C CG  . LEU A 1 209 ? 123.459 152.562 135.600 1.00 59.16  ?  198 LEU A CG  1 
ATOM   309  C CD1 . LEU A 1 209 ? 123.900 153.781 134.825 1.00 59.16  ?  198 LEU A CD1 1 
ATOM   310  C CD2 . LEU A 1 209 ? 124.495 152.185 136.638 1.00 59.16  ?  198 LEU A CD2 1 
ATOM   311  N N   . ALA A 1 210 ? 119.478 152.740 138.029 1.00 59.15  ?  199 ALA A N   1 
ATOM   312  C CA  . ALA A 1 210 ? 118.574 153.333 139.008 1.00 59.15  ?  199 ALA A CA  1 
ATOM   313  C C   . ALA A 1 210 ? 118.349 152.413 140.200 1.00 59.15  ?  199 ALA A C   1 
ATOM   314  O O   . ALA A 1 210 ? 118.231 152.894 141.331 1.00 59.15  ?  199 ALA A O   1 
ATOM   315  C CB  . ALA A 1 210 ? 117.241 153.680 138.350 1.00 59.15  ?  199 ALA A CB  1 
ATOM   316  N N   . GLY A 1 211 ? 118.312 151.098 139.971 1.00 58.58  ?  200 GLY A N   1 
ATOM   317  C CA  . GLY A 1 211 ? 118.197 150.163 141.079 1.00 58.58  ?  200 GLY A CA  1 
ATOM   318  C C   . GLY A 1 211 ? 119.413 150.173 141.986 1.00 58.58  ?  200 GLY A C   1 
ATOM   319  O O   . GLY A 1 211 ? 119.280 150.117 143.212 1.00 58.58  ?  200 GLY A O   1 
ATOM   320  N N   . ALA A 1 212 ? 120.610 150.276 141.399 1.00 58.49  ?  201 ALA A N   1 
ATOM   321  C CA  . ALA A 1 212 ? 121.823 150.375 142.207 1.00 58.49  ?  201 ALA A CA  1 
ATOM   322  C C   . ALA A 1 212 ? 121.863 151.673 143.009 1.00 58.49  ?  201 ALA A C   1 
ATOM   323  O O   . ALA A 1 212 ? 122.250 151.668 144.187 1.00 58.49  ?  201 ALA A O   1 
ATOM   324  C CB  . ALA A 1 212 ? 123.057 150.260 141.316 1.00 58.49  ?  201 ALA A CB  1 
ATOM   325  N N   . VAL A 1 213 ? 121.448 152.787 142.397 1.00 58.80  ?  202 VAL A N   1 
ATOM   326  C CA  . VAL A 1 213 ? 121.448 154.073 143.095 1.00 58.80  ?  202 VAL A CA  1 
ATOM   327  C C   . VAL A 1 213 ? 120.411 154.079 144.220 1.00 58.80  ?  202 VAL A C   1 
ATOM   328  O O   . VAL A 1 213 ? 120.661 154.613 145.308 1.00 58.80  ?  202 VAL A O   1 
ATOM   329  C CB  . VAL A 1 213 ? 121.228 155.214 142.082 1.00 58.80  ?  202 VAL A CB  1 
ATOM   330  C CG1 . VAL A 1 213 ? 120.890 156.535 142.759 1.00 58.80  ?  202 VAL A CG1 1 
ATOM   331  C CG2 . VAL A 1 213 ? 122.464 155.387 141.218 1.00 58.80  ?  202 VAL A CG2 1 
ATOM   332  N N   . VAL A 1 214 ? 119.261 153.433 144.003 1.00 60.20  ?  203 VAL A N   1 
ATOM   333  C CA  . VAL A 1 214 ? 118.230 153.361 145.038 1.00 60.20  ?  203 VAL A CA  1 
ATOM   334  C C   . VAL A 1 214 ? 118.685 152.478 146.198 1.00 60.20  ?  203 VAL A C   1 
ATOM   335  O O   . VAL A 1 214 ? 118.482 152.823 147.369 1.00 60.20  ?  203 VAL A O   1 
ATOM   336  C CB  . VAL A 1 214 ? 116.905 152.878 144.414 1.00 60.20  ?  203 VAL A CB  1 
ATOM   337  C CG1 . VAL A 1 214 ? 115.972 152.258 145.446 1.00 60.20  ?  203 VAL A CG1 1 
ATOM   338  C CG2 . VAL A 1 214 ? 116.211 154.033 143.717 1.00 60.20  ?  203 VAL A CG2 1 
ATOM   339  N N   . ILE A 1 215 ? 119.347 151.356 145.898 1.00 58.97  ?  204 ILE A N   1 
ATOM   340  C CA  . ILE A 1 215 ? 119.825 150.460 146.951 1.00 58.97  ?  204 ILE A CA  1 
ATOM   341  C C   . ILE A 1 215 ? 120.953 151.107 147.759 1.00 58.97  ?  204 ILE A C   1 
ATOM   342  O O   . ILE A 1 215 ? 121.036 150.912 148.980 1.00 58.97  ?  204 ILE A O   1 
ATOM   343  C CB  . ILE A 1 215 ? 120.233 149.112 146.317 1.00 58.97  ?  204 ILE A CB  1 
ATOM   344  C CG1 . ILE A 1 215 ? 118.987 148.313 145.944 1.00 58.97  ?  204 ILE A CG1 1 
ATOM   345  C CG2 . ILE A 1 215 ? 121.103 148.261 147.232 1.00 58.97  ?  204 ILE A CG2 1 
ATOM   346  C CD1 . ILE A 1 215 ? 119.286 147.003 145.262 1.00 58.97  ?  204 ILE A CD1 1 
ATOM   347  N N   . ILE A 1 216 ? 121.785 151.940 147.121 1.00 60.35  ?  205 ILE A N   1 
ATOM   348  C CA  . ILE A 1 216 ? 122.915 152.560 147.818 1.00 60.35  ?  205 ILE A CA  1 
ATOM   349  C C   . ILE A 1 216 ? 122.432 153.574 148.856 1.00 60.35  ?  205 ILE A C   1 
ATOM   350  O O   . ILE A 1 216 ? 122.886 153.567 150.006 1.00 60.35  ?  205 ILE A O   1 
ATOM   351  C CB  . ILE A 1 216 ? 123.885 153.191 146.800 1.00 60.35  ?  205 ILE A CB  1 
ATOM   352  C CG1 . ILE A 1 216 ? 124.831 152.128 146.255 1.00 60.35  ?  205 ILE A CG1 1 
ATOM   353  C CG2 . ILE A 1 216 ? 124.708 154.310 147.414 1.00 60.35  ?  205 ILE A CG2 1 
ATOM   354  C CD1 . ILE A 1 216 ? 125.448 152.487 144.937 1.00 60.35  ?  205 ILE A CD1 1 
ATOM   355  N N   . VAL A 1 217 ? 121.467 154.425 148.491 1.00 62.41  ?  206 VAL A N   1 
ATOM   356  C CA  . VAL A 1 217 ? 121.000 155.462 149.413 1.00 62.41  ?  206 VAL A CA  1 
ATOM   357  C C   . VAL A 1 217 ? 120.030 154.949 150.465 1.00 62.41  ?  206 VAL A C   1 
ATOM   358  O O   . VAL A 1 217 ? 119.526 155.750 151.261 1.00 62.41  ?  206 VAL A O   1 
ATOM   359  C CB  . VAL A 1 217 ? 120.318 156.632 148.678 1.00 62.41  ?  206 VAL A CB  1 
ATOM   360  C CG1 . VAL A 1 217 ? 121.304 157.330 147.767 1.00 62.41  ?  206 VAL A CG1 1 
ATOM   361  C CG2 . VAL A 1 217 ? 119.118 156.142 147.899 1.00 62.41  ?  206 VAL A CG2 1 
ATOM   362  N N   . ARG A 1 218 ? 119.741 153.649 150.493 1.00 68.06  ?  207 ARG A N   1 
ATOM   363  C CA  . ARG A 1 218 ? 118.924 153.065 151.544 1.00 68.06  ?  207 ARG A CA  1 
ATOM   364  C C   . ARG A 1 218 ? 119.716 152.195 152.508 1.00 68.06  ?  207 ARG A C   1 
ATOM   365  O O   . ARG A 1 218 ? 119.178 151.820 153.555 1.00 68.06  ?  207 ARG A O   1 
ATOM   366  C CB  . ARG A 1 218 ? 117.780 152.241 150.937 1.00 68.06  ?  207 ARG A CB  1 
ATOM   367  C CG  . ARG A 1 218 ? 116.595 153.076 150.484 1.00 68.06  ?  207 ARG A CG  1 
ATOM   368  C CD  . ARG A 1 218 ? 115.443 152.201 150.026 1.00 68.06  ?  207 ARG A CD  1 
ATOM   369  N NE  . ARG A 1 218 ? 114.964 151.324 151.090 1.00 68.06  ?  207 ARG A NE  1 
ATOM   370  C CZ  . ARG A 1 218 ? 114.984 149.996 151.033 1.00 68.06  ?  207 ARG A CZ  1 
ATOM   371  N NH1 . ARG A 1 218 ? 115.459 149.383 149.959 1.00 68.06  1  207 ARG A NH1 1 
ATOM   372  N NH2 . ARG A 1 218 ? 114.527 149.280 152.050 1.00 68.06  ?  207 ARG A NH2 1 
ATOM   373  N N   . ALA A 1 219 ? 120.956 151.846 152.181 1.00 72.97  ?  208 ALA A N   1 
ATOM   374  C CA  . ALA A 1 219 ? 121.858 151.292 153.183 1.00 72.97  ?  208 ALA A CA  1 
ATOM   375  C C   . ALA A 1 219 ? 122.188 152.396 154.176 1.00 72.97  ?  208 ALA A C   1 
ATOM   376  O O   . ALA A 1 219 ? 122.517 153.509 153.753 1.00 72.97  ?  208 ALA A O   1 
ATOM   377  C CB  . ALA A 1 219 ? 123.127 150.754 152.532 1.00 72.97  ?  208 ALA A CB  1 
ATOM   378  N N   . PRO A 1 220 ? 122.071 152.145 155.498 1.00 81.74  ?  209 PRO A N   1 
ATOM   379  C CA  . PRO A 1 220 ? 121.922 153.259 156.453 1.00 81.74  ?  209 PRO A CA  1 
ATOM   380  C C   . PRO A 1 220 ? 123.101 154.216 156.594 1.00 81.74  ?  209 PRO A C   1 
ATOM   381  O O   . PRO A 1 220 ? 123.060 155.298 155.994 1.00 81.74  ?  209 PRO A O   1 
ATOM   382  C CB  . PRO A 1 220 ? 121.662 152.533 157.781 1.00 81.74  ?  209 PRO A CB  1 
ATOM   383  C CG  . PRO A 1 220 ? 122.194 151.137 157.584 1.00 81.74  ?  209 PRO A CG  1 
ATOM   384  C CD  . PRO A 1 220 ? 122.005 150.824 156.145 1.00 81.74  ?  209 PRO A CD  1 
ATOM   385  N N   . ARG A 1 221 ? 124.176 153.778 157.264 1.00 87.40  ?  210 ARG A N   1 
ATOM   386  C CA  . ARG A 1 221 ? 125.380 154.556 157.555 1.00 87.40  ?  210 ARG A CA  1 
ATOM   387  C C   . ARG A 1 221 ? 126.303 153.677 158.393 1.00 87.40  ?  210 ARG A C   1 
ATOM   388  O O   . ARG A 1 221 ? 125.933 152.559 158.764 1.00 87.40  ?  210 ARG A O   1 
ATOM   389  C CB  . ARG A 1 221 ? 125.061 155.865 158.305 1.00 87.40  ?  210 ARG A CB  1 
ATOM   390  C CG  . ARG A 1 221 ? 126.052 157.011 158.082 1.00 87.40  ?  210 ARG A CG  1 
ATOM   391  C CD  . ARG A 1 221 ? 126.331 157.234 156.599 1.00 87.40  ?  210 ARG A CD  1 
ATOM   392  N NE  . ARG A 1 221 ? 125.158 157.697 155.865 1.00 87.40  ?  210 ARG A NE  1 
ATOM   393  C CZ  . ARG A 1 221 ? 125.068 157.728 154.538 1.00 87.40  ?  210 ARG A CZ  1 
ATOM   394  N NH1 . ARG A 1 221 ? 126.081 157.318 153.786 1.00 87.40  1  210 ARG A NH1 1 
ATOM   395  N NH2 . ARG A 1 221 ? 123.960 158.169 153.960 1.00 87.40  ?  210 ARG A NH2 1 
ATOM   396  N N   . CYS A 1 222 ? 127.504 154.161 158.688 1.00 92.45  ?  211 CYS A N   1 
ATOM   397  C CA  . CYS A 1 222 ? 128.312 153.647 159.780 1.00 92.45  ?  211 CYS A CA  1 
ATOM   398  C C   . CYS A 1 222 ? 128.967 154.812 160.500 1.00 92.45  ?  211 CYS A C   1 
ATOM   399  O O   . CYS A 1 222 ? 129.337 155.815 159.885 1.00 92.45  ?  211 CYS A O   1 
ATOM   400  C CB  . CYS A 1 222 ? 129.354 152.654 159.291 1.00 92.45  ?  211 CYS A CB  1 
ATOM   401  S SG  . CYS A 1 222 ? 130.091 153.147 157.759 1.00 92.45  ?  211 CYS A SG  1 
ATOM   402  N N   . ARG A 1 223 ? 129.094 154.667 161.814 1.00 99.21  ?  212 ARG A N   1 
ATOM   403  C CA  . ARG A 1 223 ? 129.525 155.744 162.684 1.00 99.21  ?  212 ARG A CA  1 
ATOM   404  C C   . ARG A 1 223 ? 131.013 156.024 162.511 1.00 99.21  ?  212 ARG A C   1 
ATOM   405  O O   . ARG A 1 223 ? 131.772 155.206 161.986 1.00 99.21  ?  212 ARG A O   1 
ATOM   406  C CB  . ARG A 1 223 ? 129.213 155.397 164.138 1.00 99.21  ?  212 ARG A CB  1 
ATOM   407  C CG  . ARG A 1 223 ? 129.407 153.927 164.460 1.00 99.21  ?  212 ARG A CG  1 
ATOM   408  C CD  . ARG A 1 223 ? 128.746 153.547 165.774 1.00 99.21  ?  212 ARG A CD  1 
ATOM   409  N NE  . ARG A 1 223 ? 129.185 154.399 166.873 1.00 99.21  ?  212 ARG A NE  1 
ATOM   410  C CZ  . ARG A 1 223 ? 128.907 154.171 168.151 1.00 99.21  ?  212 ARG A CZ  1 
ATOM   411  N NH1 . ARG A 1 223 ? 129.348 155.001 169.085 1.00 99.21  1  212 ARG A NH1 1 
ATOM   412  N NH2 . ARG A 1 223 ? 128.192 153.110 168.497 1.00 99.21  ?  212 ARG A NH2 1 
ATOM   413  N N   . GLU A 1 224 ? 131.443 157.206 162.933 1.00 102.77 ?  213 GLU A N   1 
ATOM   414  C CA  . GLU A 1 224 ? 132.845 157.585 162.787 1.00 102.77 ?  213 GLU A CA  1 
ATOM   415  C C   . GLU A 1 224 ? 133.743 157.008 163.876 1.00 102.77 ?  213 GLU A C   1 
ATOM   416  O O   . GLU A 1 224 ? 133.360 156.951 165.044 1.00 102.77 ?  213 GLU A O   1 
ATOM   417  C CB  . GLU A 1 224 ? 132.983 159.110 162.753 1.00 102.77 ?  213 GLU A CB  1 
ATOM   418  C CG  . GLU A 1 224 ? 132.886 159.772 164.118 1.00 102.77 ?  213 GLU A CG  1 
ATOM   419  C CD  . GLU A 1 224 ? 132.781 161.282 164.027 1.00 102.77 ?  213 GLU A CD  1 
ATOM   420  O OE1 . GLU A 1 224 ? 132.984 161.828 162.922 1.00 102.77 ?  213 GLU A OE1 1 
ATOM   421  O OE2 . GLU A 1 224 ? 132.495 161.923 165.060 1.00 102.77 -1 213 GLU A OE2 1 
ATOM   422  N N   . LEU A 1 225 ? 134.945 156.586 163.487 1.00 31.26  ?  214 LEU A N   1 
ATOM   423  C CA  . LEU A 1 225 ? 135.904 156.038 164.440 1.00 31.26  ?  214 LEU A CA  1 
ATOM   424  C C   . LEU A 1 225 ? 136.060 157.071 165.544 1.00 31.26  ?  214 LEU A C   1 
ATOM   425  O O   . LEU A 1 225 ? 135.635 158.215 165.379 1.00 31.26  ?  214 LEU A O   1 
ATOM   426  C CB  . LEU A 1 225 ? 137.248 155.772 163.764 1.00 31.26  ?  214 LEU A CB  1 
ATOM   427  C CG  . LEU A 1 225 ? 137.220 154.859 162.536 1.00 31.26  ?  214 LEU A CG  1 
ATOM   428  C CD1 . LEU A 1 225 ? 138.632 154.515 162.089 1.00 31.26  ?  214 LEU A CD1 1 
ATOM   429  C CD2 . LEU A 1 225 ? 136.420 153.597 162.822 1.00 31.26  ?  214 LEU A CD2 1 
ATOM   430  N N   . PRO A 1 226 ? 136.658 156.700 166.670 1.00 31.31  ?  215 PRO A N   1 
ATOM   431  C CA  . PRO A 1 226 ? 136.778 157.697 167.734 1.00 31.31  ?  215 PRO A CA  1 
ATOM   432  C C   . PRO A 1 226 ? 138.132 158.372 167.892 1.00 31.31  ?  215 PRO A C   1 
ATOM   433  O O   . PRO A 1 226 ? 138.312 159.049 168.909 1.00 31.31  ?  215 PRO A O   1 
ATOM   434  C CB  . PRO A 1 226 ? 136.456 156.865 168.975 1.00 31.31  ?  215 PRO A CB  1 
ATOM   435  C CG  . PRO A 1 226 ? 136.974 155.548 168.654 1.00 31.31  ?  215 PRO A CG  1 
ATOM   436  C CD  . PRO A 1 226 ? 136.659 155.335 167.221 1.00 31.31  ?  215 PRO A CD  1 
ATOM   437  N N   . ALA A 1 227 ? 139.063 158.212 166.940 1.00 26.87  ?  216 ALA A N   1 
ATOM   438  C CA  . ALA A 1 227 ? 140.367 158.885 166.929 1.00 26.87  ?  216 ALA A CA  1 
ATOM   439  C C   . ALA A 1 227 ? 141.199 158.617 168.182 1.00 26.87  ?  216 ALA A C   1 
ATOM   440  O O   . ALA A 1 227 ? 141.373 159.506 169.017 1.00 26.87  ?  216 ALA A O   1 
ATOM   441  C CB  . ALA A 1 227 ? 140.208 160.396 166.718 1.00 26.87  ?  216 ALA A CB  1 
ATOM   442  N N   . GLN A 1 228 ? 141.691 157.391 168.323 1.00 26.16  ?  217 GLN A N   1 
ATOM   443  C CA  . GLN A 1 228 ? 142.269 156.889 169.556 1.00 26.16  ?  217 GLN A CA  1 
ATOM   444  C C   . GLN A 1 228 ? 143.694 157.380 169.753 1.00 26.16  ?  217 GLN A C   1 
ATOM   445  O O   . GLN A 1 228 ? 144.429 157.634 168.800 1.00 26.16  ?  217 GLN A O   1 
ATOM   446  C CB  . GLN A 1 228 ? 142.251 155.363 169.572 1.00 26.16  ?  217 GLN A CB  1 
ATOM   447  C CG  . GLN A 1 228 ? 140.862 154.810 169.524 1.00 26.16  ?  217 GLN A CG  1 
ATOM   448  C CD  . GLN A 1 228 ? 140.775 153.404 170.025 1.00 26.16  ?  217 GLN A CD  1 
ATOM   449  O OE1 . GLN A 1 228 ? 141.497 152.524 169.571 1.00 26.16  ?  217 GLN A OE1 1 
ATOM   450  N NE2 . GLN A 1 228 ? 139.891 153.181 170.987 1.00 26.16  ?  217 GLN A NE2 1 
ATOM   451  N N   . LYS A 1 229 ? 144.074 157.476 171.026 1.00 19.74  ?  218 LYS A N   1 
ATOM   452  C CA  . LYS A 1 229 ? 145.432 157.762 171.448 1.00 19.74  ?  218 LYS A CA  1 
ATOM   453  C C   . LYS A 1 229 ? 146.244 156.474 171.421 1.00 19.74  ?  218 LYS A C   1 
ATOM   454  O O   . LYS A 1 229 ? 145.727 155.402 171.113 1.00 19.74  ?  218 LYS A O   1 
ATOM   455  C CB  . LYS A 1 229 ? 145.423 158.388 172.833 1.00 19.74  ?  218 LYS A CB  1 
ATOM   456  C CG  . LYS A 1 229 ? 144.559 159.597 172.941 1.00 19.74  ?  218 LYS A CG  1 
ATOM   457  C CD  . LYS A 1 229 ? 145.038 160.673 172.000 1.00 19.74  ?  218 LYS A CD  1 
ATOM   458  C CE  . LYS A 1 229 ? 144.292 161.963 172.213 1.00 19.74  ?  218 LYS A CE  1 
ATOM   459  N NZ  . LYS A 1 229 ? 144.559 162.511 173.560 1.00 19.74  1  218 LYS A NZ  1 
ATOM   460  N N   . TRP A 1 230 ? 147.526 156.560 171.747 1.00 15.13  ?  219 TRP A N   1 
ATOM   461  C CA  . TRP A 1 230 ? 148.392 155.399 171.668 1.00 15.13  ?  219 TRP A CA  1 
ATOM   462  C C   . TRP A 1 230 ? 148.226 154.463 172.845 1.00 15.13  ?  219 TRP A C   1 
ATOM   463  O O   . TRP A 1 230 ? 148.685 153.319 172.786 1.00 15.13  ?  219 TRP A O   1 
ATOM   464  C CB  . TRP A 1 230 ? 149.854 155.825 171.561 1.00 15.13  ?  219 TRP A CB  1 
ATOM   465  C CG  . TRP A 1 230 ? 150.397 156.618 172.692 1.00 15.13  ?  219 TRP A CG  1 
ATOM   466  C CD1 . TRP A 1 230 ? 150.515 157.956 172.746 1.00 15.13  ?  219 TRP A CD1 1 
ATOM   467  C CD2 . TRP A 1 230 ? 150.956 156.117 173.912 1.00 15.13  ?  219 TRP A CD2 1 
ATOM   468  N NE1 . TRP A 1 230 ? 151.093 158.336 173.920 1.00 15.13  ?  219 TRP A NE1 1 
ATOM   469  C CE2 . TRP A 1 230 ? 151.357 157.222 174.663 1.00 15.13  ?  219 TRP A CE2 1 
ATOM   470  C CE3 . TRP A 1 230 ? 151.121 154.841 174.453 1.00 15.13  ?  219 TRP A CE3 1 
ATOM   471  C CZ2 . TRP A 1 230 ? 151.924 157.097 175.911 1.00 15.13  ?  219 TRP A CZ2 1 
ATOM   472  C CZ3 . TRP A 1 230 ? 151.674 154.721 175.679 1.00 15.13  ?  219 TRP A CZ3 1 
ATOM   473  C CH2 . TRP A 1 230 ? 152.077 155.835 176.399 1.00 15.13  ?  219 TRP A CH2 1 
ATOM   474  N N   . TRP A 1 231 ? 147.624 154.931 173.928 1.00 15.39  ?  220 TRP A N   1 
ATOM   475  C CA  . TRP A 1 231 ? 147.357 154.076 175.061 1.00 15.39  ?  220 TRP A CA  1 
ATOM   476  C C   . TRP A 1 231 ? 145.968 153.496 175.029 1.00 15.39  ?  220 TRP A C   1 
ATOM   477  O O   . TRP A 1 231 ? 145.526 152.913 176.013 1.00 15.39  ?  220 TRP A O   1 
ATOM   478  C CB  . TRP A 1 231 ? 147.597 154.836 176.355 1.00 15.39  ?  220 TRP A CB  1 
ATOM   479  C CG  . TRP A 1 231 ? 146.676 155.954 176.643 1.00 15.39  ?  220 TRP A CG  1 
ATOM   480  C CD1 . TRP A 1 231 ? 145.505 155.890 177.319 1.00 15.39  ?  220 TRP A CD1 1 
ATOM   481  C CD2 . TRP A 1 231 ? 146.878 157.329 176.331 1.00 15.39  ?  220 TRP A CD2 1 
ATOM   482  N NE1 . TRP A 1 231 ? 144.947 157.124 177.425 1.00 15.39  ?  220 TRP A NE1 1 
ATOM   483  C CE2 . TRP A 1 231 ? 145.774 158.032 176.829 1.00 15.39  ?  220 TRP A CE2 1 
ATOM   484  C CE3 . TRP A 1 231 ? 147.886 158.036 175.677 1.00 15.39  ?  220 TRP A CE3 1 
ATOM   485  C CZ2 . TRP A 1 231 ? 145.652 159.400 176.696 1.00 15.39  ?  220 TRP A CZ2 1 
ATOM   486  C CZ3 . TRP A 1 231 ? 147.759 159.381 175.543 1.00 15.39  ?  220 TRP A CZ3 1 
ATOM   487  C CH2 . TRP A 1 231 ? 146.654 160.054 176.051 1.00 15.39  ?  220 TRP A CH2 1 
ATOM   488  N N   . HIS A 1 232 ? 145.268 153.649 173.925 1.00 15.63  ?  221 HIS A N   1 
ATOM   489  C CA  . HIS A 1 232 ? 143.984 153.019 173.727 1.00 15.63  ?  221 HIS A CA  1 
ATOM   490  C C   . HIS A 1 232 ? 144.104 151.769 172.888 1.00 15.63  ?  221 HIS A C   1 
ATOM   491  O O   . HIS A 1 232 ? 143.089 151.145 172.584 1.00 15.63  ?  221 HIS A O   1 
ATOM   492  C CB  . HIS A 1 232 ? 143.019 153.985 173.052 1.00 15.63  ?  221 HIS A CB  1 
ATOM   493  C CG  . HIS A 1 232 ? 142.575 155.117 173.920 1.00 15.63  ?  221 HIS A CG  1 
ATOM   494  N ND1 . HIS A 1 232 ? 141.286 155.591 173.919 1.00 15.63  ?  221 HIS A ND1 1 
ATOM   495  C CD2 . HIS A 1 232 ? 143.247 155.869 174.817 1.00 15.63  ?  221 HIS A CD2 1 
ATOM   496  C CE1 . HIS A 1 232 ? 141.185 156.585 174.778 1.00 15.63  ?  221 HIS A CE1 1 
ATOM   497  N NE2 . HIS A 1 232 ? 142.363 156.776 175.333 1.00 15.63  ?  221 HIS A NE2 1 
ATOM   498  N N   . THR A 1 233 ? 145.327 151.379 172.528 1.00 16.96  ?  222 THR A N   1 
ATOM   499  C CA  . THR A 1 233 ? 145.565 150.403 171.477 1.00 16.96  ?  222 THR A CA  1 
ATOM   500  C C   . THR A 1 233 ? 146.310 149.165 171.962 1.00 16.96  ?  222 THR A C   1 
ATOM   501  O O   . THR A 1 233 ? 146.674 148.315 171.158 1.00 16.96  ?  222 THR A O   1 
ATOM   502  C CB  . THR A 1 233 ? 146.316 151.067 170.329 1.00 16.96  ?  222 THR A CB  1 
ATOM   503  O OG1 . THR A 1 233 ? 147.408 151.819 170.852 1.00 16.96  ?  222 THR A OG1 1 
ATOM   504  C CG2 . THR A 1 233 ? 145.405 152.010 169.573 1.00 16.96  ?  222 THR A CG2 1 
ATOM   505  N N   . GLY A 1 234 ? 146.527 149.028 173.261 1.00 16.23  ?  223 GLY A N   1 
ATOM   506  C CA  . GLY A 1 234 ? 147.090 147.804 173.789 1.00 16.23  ?  223 GLY A CA  1 
ATOM   507  C C   . GLY A 1 234 ? 147.474 148.004 175.236 1.00 16.23  ?  223 GLY A C   1 
ATOM   508  O O   . GLY A 1 234 ? 147.028 148.952 175.874 1.00 16.23  ?  223 GLY A O   1 
ATOM   509  N N   . ALA A 1 235 ? 148.327 147.116 175.732 1.00 13.30  ?  224 ALA A N   1 
ATOM   510  C CA  . ALA A 1 235 ? 148.651 147.041 177.146 1.00 13.30  ?  224 ALA A CA  1 
ATOM   511  C C   . ALA A 1 235 ? 149.904 147.832 177.478 1.00 13.30  ?  224 ALA A C   1 
ATOM   512  O O   . ALA A 1 235 ? 150.754 148.062 176.626 1.00 13.30  ?  224 ALA A O   1 
ATOM   513  C CB  . ALA A 1 235 ? 148.843 145.592 177.569 1.00 13.30  ?  224 ALA A CB  1 
ATOM   514  N N   . LEU A 1 236 ? 150.006 148.253 178.728 1.00 12.96  ?  225 LEU A N   1 
ATOM   515  C CA  . LEU A 1 236 ? 151.225 148.837 179.258 1.00 12.96  ?  225 LEU A CA  1 
ATOM   516  C C   . LEU A 1 236 ? 151.906 147.831 180.175 1.00 12.96  ?  225 LEU A C   1 
ATOM   517  O O   . LEU A 1 236 ? 151.308 146.853 180.615 1.00 12.96  ?  225 LEU A O   1 
ATOM   518  C CB  . LEU A 1 236 ? 150.953 150.143 180.010 1.00 12.96  ?  225 LEU A CB  1 
ATOM   519  C CG  . LEU A 1 236 ? 150.036 151.185 179.385 1.00 12.96  ?  225 LEU A CG  1 
ATOM   520  C CD1 . LEU A 1 236 ? 150.010 152.394 180.258 1.00 12.96  ?  225 LEU A CD1 1 
ATOM   521  C CD2 . LEU A 1 236 ? 150.448 151.566 177.986 1.00 12.96  ?  225 LEU A CD2 1 
ATOM   522  N N   . TYR A 1 237 ? 153.172 148.108 180.472 1.00 16.70  ?  226 TYR A N   1 
ATOM   523  C CA  . TYR A 1 237 ? 154.085 147.147 181.083 1.00 16.70  ?  226 TYR A CA  1 
ATOM   524  C C   . TYR A 1 237 ? 154.955 147.900 182.076 1.00 16.70  ?  226 TYR A C   1 
ATOM   525  O O   . TYR A 1 237 ? 155.741 148.749 181.668 1.00 16.70  ?  226 TYR A O   1 
ATOM   526  C CB  . TYR A 1 237 ? 154.931 146.485 180.004 1.00 16.70  ?  226 TYR A CB  1 
ATOM   527  C CG  . TYR A 1 237 ? 155.659 145.227 180.394 1.00 16.70  ?  226 TYR A CG  1 
ATOM   528  C CD1 . TYR A 1 237 ? 155.081 143.987 180.205 1.00 16.70  ?  226 TYR A CD1 1 
ATOM   529  C CD2 . TYR A 1 237 ? 156.947 145.281 180.906 1.00 16.70  ?  226 TYR A CD2 1 
ATOM   530  C CE1 . TYR A 1 237 ? 155.746 142.847 180.527 1.00 16.70  ?  226 TYR A CE1 1 
ATOM   531  C CE2 . TYR A 1 237 ? 157.616 144.147 181.247 1.00 16.70  ?  226 TYR A CE2 1 
ATOM   532  C CZ  . TYR A 1 237 ? 157.014 142.930 181.051 1.00 16.70  ?  226 TYR A CZ  1 
ATOM   533  O OH  . TYR A 1 237 ? 157.683 141.782 181.391 1.00 16.70  ?  226 TYR A OH  1 
ATOM   534  N N   . ARG A 1 238 ? 154.824 147.610 183.363 1.00 15.51  ?  227 ARG A N   1 
ATOM   535  C CA  . ARG A 1 238 ? 155.539 148.362 184.386 1.00 15.51  ?  227 ARG A CA  1 
ATOM   536  C C   . ARG A 1 238 ? 156.824 147.653 184.782 1.00 15.51  ?  227 ARG A C   1 
ATOM   537  O O   . ARG A 1 238 ? 156.794 146.502 185.210 1.00 15.51  ?  227 ARG A O   1 
ATOM   538  C CB  . ARG A 1 238 ? 154.671 148.564 185.625 1.00 15.51  ?  227 ARG A CB  1 
ATOM   539  C CG  . ARG A 1 238 ? 153.315 149.125 185.373 1.00 15.51  ?  227 ARG A CG  1 
ATOM   540  C CD  . ARG A 1 238 ? 152.547 149.255 186.652 1.00 15.51  ?  227 ARG A CD  1 
ATOM   541  N NE  . ARG A 1 238 ? 151.920 148.003 187.043 1.00 15.51  ?  227 ARG A NE  1 
ATOM   542  C CZ  . ARG A 1 238 ? 150.784 147.924 187.711 1.00 15.51  ?  227 ARG A CZ  1 
ATOM   543  N NH1 . ARG A 1 238 ? 150.157 149.023 188.050 1.00 15.51  1  227 ARG A NH1 1 
ATOM   544  N NH2 . ARG A 1 238 ? 150.276 146.755 188.036 1.00 15.51  ?  227 ARG A NH2 1 
ATOM   545  N N   . ILE A 1 239 ? 157.949 148.346 184.650 1.00 17.71  ?  228 ILE A N   1 
ATOM   546  C CA  . ILE A 1 239 ? 159.241 147.850 185.107 1.00 17.71  ?  228 ILE A CA  1 
ATOM   547  C C   . ILE A 1 239 ? 159.700 148.744 186.249 1.00 17.71  ?  228 ILE A C   1 
ATOM   548  O O   . ILE A 1 239 ? 160.280 149.808 186.038 1.00 17.71  ?  228 ILE A O   1 
ATOM   549  C CB  . ILE A 1 239 ? 160.265 147.789 183.959 1.00 17.71  ?  228 ILE A CB  1 
ATOM   550  C CG1 . ILE A 1 239 ? 159.789 146.806 182.896 1.00 17.71  ?  228 ILE A CG1 1 
ATOM   551  C CG2 . ILE A 1 239 ? 161.593 147.306 184.457 1.00 17.71  ?  228 ILE A CG2 1 
ATOM   552  C CD1 . ILE A 1 239 ? 160.520 146.884 181.630 1.00 17.71  ?  228 ILE A CD1 1 
ATOM   553  N N   . GLY A 1 240 ? 159.400 148.323 187.468 1.00 27.80  ?  229 GLY A N   1 
ATOM   554  C CA  . GLY A 1 240 ? 159.569 149.154 188.635 1.00 27.80  ?  229 GLY A CA  1 
ATOM   555  C C   . GLY A 1 240 ? 160.975 149.155 189.170 1.00 27.80  ?  229 GLY A C   1 
ATOM   556  O O   . GLY A 1 240 ? 161.528 150.204 189.503 1.00 27.80  ?  229 GLY A O   1 
ATOM   557  N N   . ASP A 1 241 ? 161.554 147.970 189.287 1.00 40.22  ?  230 ASP A N   1 
ATOM   558  C CA  . ASP A 1 241 ? 162.956 147.830 189.628 1.00 40.22  ?  230 ASP A CA  1 
ATOM   559  C C   . ASP A 1 241 ? 163.693 147.438 188.365 1.00 40.22  ?  230 ASP A C   1 
ATOM   560  O O   . ASP A 1 241 ? 163.268 146.527 187.653 1.00 40.22  ?  230 ASP A O   1 
ATOM   561  C CB  . ASP A 1 241 ? 163.170 146.788 190.718 1.00 40.22  ?  230 ASP A CB  1 
ATOM   562  C CG  . ASP A 1 241 ? 164.529 146.903 191.352 1.00 40.22  ?  230 ASP A CG  1 
ATOM   563  O OD1 . ASP A 1 241 ? 164.733 147.852 192.135 1.00 40.22  ?  230 ASP A OD1 1 
ATOM   564  O OD2 . ASP A 1 241 ? 165.396 146.058 191.072 1.00 40.22  -1 230 ASP A OD2 1 
ATOM   565  N N   . LEU A 1 242 ? 164.778 148.138 188.081 1.00 43.74  ?  231 LEU A N   1 
ATOM   566  C CA  . LEU A 1 242 ? 165.466 147.939 186.822 1.00 43.74  ?  231 LEU A CA  1 
ATOM   567  C C   . LEU A 1 242 ? 166.554 146.891 186.917 1.00 43.74  ?  231 LEU A C   1 
ATOM   568  O O   . LEU A 1 242 ? 166.713 146.097 185.987 1.00 43.74  ?  231 LEU A O   1 
ATOM   569  C CB  . LEU A 1 242 ? 166.057 149.264 186.350 1.00 43.74  ?  231 LEU A CB  1 
ATOM   570  C CG  . LEU A 1 242 ? 166.392 149.372 184.874 1.00 43.74  ?  231 LEU A CG  1 
ATOM   571  C CD1 . LEU A 1 242 ? 165.179 149.077 184.065 1.00 43.74  ?  231 LEU A CD1 1 
ATOM   572  C CD2 . LEU A 1 242 ? 166.853 150.770 184.591 1.00 43.74  ?  231 LEU A CD2 1 
ATOM   573  N N   . GLN A 1 243 ? 167.278 146.842 188.035 1.00 47.59  ?  232 GLN A N   1 
ATOM   574  C CA  . GLN A 1 243 ? 168.396 145.916 188.155 1.00 47.59  ?  232 GLN A CA  1 
ATOM   575  C C   . GLN A 1 243 ? 167.920 144.485 188.359 1.00 47.59  ?  232 GLN A C   1 
ATOM   576  O O   . GLN A 1 243 ? 168.668 143.536 188.107 1.00 47.59  ?  232 GLN A O   1 
ATOM   577  C CB  . GLN A 1 243 ? 169.325 146.354 189.283 1.00 47.59  ?  232 GLN A CB  1 
ATOM   578  C CG  . GLN A 1 243 ? 168.733 146.356 190.674 1.00 47.59  ?  232 GLN A CG  1 
ATOM   579  C CD  . GLN A 1 243 ? 168.063 147.675 191.048 1.00 47.59  ?  232 GLN A CD  1 
ATOM   580  O OE1 . GLN A 1 243 ? 167.281 148.230 190.278 1.00 47.59  ?  232 GLN A OE1 1 
ATOM   581  N NE2 . GLN A 1 243 ? 168.388 148.189 192.232 1.00 47.59  ?  232 GLN A NE2 1 
ATOM   582  N N   . ALA A 1 244 ? 166.687 144.305 188.822 1.00 42.83  ?  233 ALA A N   1 
ATOM   583  C CA  . ALA A 1 244 ? 166.112 142.972 188.901 1.00 42.83  ?  233 ALA A CA  1 
ATOM   584  C C   . ALA A 1 244 ? 165.506 142.512 187.584 1.00 42.83  ?  233 ALA A C   1 
ATOM   585  O O   . ALA A 1 244 ? 165.223 141.323 187.433 1.00 42.83  ?  233 ALA A O   1 
ATOM   586  C CB  . ALA A 1 244 ? 165.055 142.930 189.998 1.00 42.83  ?  233 ALA A CB  1 
ATOM   587  N N   . PHE A 1 245 ? 165.310 143.416 186.630 1.00 38.16  ?  234 PHE A N   1 
ATOM   588  C CA  . PHE A 1 245 ? 164.735 143.031 185.351 1.00 38.16  ?  234 PHE A CA  1 
ATOM   589  C C   . PHE A 1 245 ? 165.775 142.372 184.458 1.00 38.16  ?  234 PHE A C   1 
ATOM   590  O O   . PHE A 1 245 ? 165.439 141.488 183.662 1.00 38.16  ?  234 PHE A O   1 
ATOM   591  C CB  . PHE A 1 245 ? 164.123 144.253 184.664 1.00 38.16  ?  234 PHE A CB  1 
ATOM   592  C CG  . PHE A 1 245 ? 163.386 143.931 183.400 1.00 38.16  ?  234 PHE A CG  1 
ATOM   593  C CD1 . PHE A 1 245 ? 162.383 142.988 183.390 1.00 38.16  ?  234 PHE A CD1 1 
ATOM   594  C CD2 . PHE A 1 245 ? 163.700 144.571 182.224 1.00 38.16  ?  234 PHE A CD2 1 
ATOM   595  C CE1 . PHE A 1 245 ? 161.721 142.686 182.237 1.00 38.16  ?  234 PHE A CE1 1 
ATOM   596  C CE2 . PHE A 1 245 ? 163.035 144.271 181.075 1.00 38.16  ?  234 PHE A CE2 1 
ATOM   597  C CZ  . PHE A 1 245 ? 162.042 143.331 181.086 1.00 38.16  ?  234 PHE A CZ  1 
ATOM   598  N N   . GLN A 1 246 ? 167.034 142.798 184.561 1.00 55.43  ?  235 GLN A N   1 
ATOM   599  C CA  . GLN A 1 246 ? 168.132 142.156 183.844 1.00 55.43  ?  235 GLN A CA  1 
ATOM   600  C C   . GLN A 1 246 ? 168.873 141.151 184.721 1.00 55.43  ?  235 GLN A C   1 
ATOM   601  O O   . GLN A 1 246 ? 168.906 139.957 184.414 1.00 55.43  ?  235 GLN A O   1 
ATOM   602  C CB  . GLN A 1 246 ? 169.128 143.198 183.333 1.00 55.43  ?  235 GLN A CB  1 
ATOM   603  C CG  . GLN A 1 246 ? 168.660 144.060 182.198 1.00 55.43  ?  235 GLN A CG  1 
ATOM   604  C CD  . GLN A 1 246 ? 168.365 145.452 182.654 1.00 55.43  ?  235 GLN A CD  1 
ATOM   605  O OE1 . GLN A 1 246 ? 168.532 145.771 183.815 1.00 55.43  ?  235 GLN A OE1 1 
ATOM   606  N NE2 . GLN A 1 246 ? 167.958 146.301 181.740 1.00 55.43  ?  235 GLN A NE2 1 
ATOM   607  N N   . GLY A 1 247 ? 169.474 141.626 185.803 1.00 64.27  ?  236 GLY A N   1 
ATOM   608  C CA  . GLY A 1 247 ? 170.270 140.778 186.663 1.00 64.27  ?  236 GLY A CA  1 
ATOM   609  C C   . GLY A 1 247 ? 171.457 141.545 187.217 1.00 64.27  ?  236 GLY A C   1 
ATOM   610  O O   . GLY A 1 247 ? 171.427 142.769 187.348 1.00 64.27  ?  236 GLY A O   1 
ATOM   611  N N   . HIS A 1 248 ? 172.514 140.790 187.525 1.00 77.24  ?  237 HIS A N   1 
ATOM   612  C CA  . HIS A 1 248 ? 173.679 141.343 188.207 1.00 77.24  ?  237 HIS A CA  1 
ATOM   613  C C   . HIS A 1 248 ? 174.530 142.141 187.225 1.00 77.24  ?  237 HIS A C   1 
ATOM   614  O O   . HIS A 1 248 ? 174.697 141.746 186.065 1.00 77.24  ?  237 HIS A O   1 
ATOM   615  C CB  . HIS A 1 248 ? 174.497 140.230 188.869 1.00 77.24  ?  237 HIS A CB  1 
ATOM   616  C CG  . HIS A 1 248 ? 175.223 139.340 187.905 1.00 77.24  ?  237 HIS A CG  1 
ATOM   617  N ND1 . HIS A 1 248 ? 176.592 139.186 187.923 1.00 77.24  ?  237 HIS A ND1 1 
ATOM   618  C CD2 . HIS A 1 248 ? 174.773 138.569 186.887 1.00 77.24  ?  237 HIS A CD2 1 
ATOM   619  C CE1 . HIS A 1 248 ? 176.954 138.353 186.964 1.00 77.24  ?  237 HIS A CE1 1 
ATOM   620  N NE2 . HIS A 1 248 ? 175.869 137.967 186.318 1.00 77.24  ?  237 HIS A NE2 1 
ATOM   621  N N   . GLY A 1 249 ? 175.037 143.288 187.677 1.00 76.73  ?  238 GLY A N   1 
ATOM   622  C CA  . GLY A 1 249 ? 175.876 144.140 186.865 1.00 76.73  ?  238 GLY A CA  1 
ATOM   623  C C   . GLY A 1 249 ? 175.167 144.926 185.784 1.00 76.73  ?  238 GLY A C   1 
ATOM   624  O O   . GLY A 1 249 ? 175.287 146.156 185.752 1.00 76.73  ?  238 GLY A O   1 
ATOM   625  N N   . ALA A 1 250 ? 174.384 144.269 184.931 1.00 73.53  ?  239 ALA A N   1 
ATOM   626  C CA  . ALA A 1 250 ? 173.833 144.866 183.726 1.00 73.53  ?  239 ALA A CA  1 
ATOM   627  C C   . ALA A 1 250 ? 172.502 145.566 183.975 1.00 73.53  ?  239 ALA A C   1 
ATOM   628  O O   . ALA A 1 250 ? 171.646 145.587 183.086 1.00 73.53  ?  239 ALA A O   1 
ATOM   629  C CB  . ALA A 1 250 ? 173.671 143.797 182.644 1.00 73.53  ?  239 ALA A CB  1 
ATOM   630  N N   . GLY A 1 251 ? 172.309 146.129 185.167 1.00 64.83  ?  240 GLY A N   1 
ATOM   631  C CA  . GLY A 1 251 ? 171.085 146.826 185.495 1.00 64.83  ?  240 GLY A CA  1 
ATOM   632  C C   . GLY A 1 251 ? 171.102 148.300 185.170 1.00 64.83  ?  240 GLY A C   1 
ATOM   633  O O   . GLY A 1 251 ? 170.617 149.116 185.952 1.00 64.83  ?  240 GLY A O   1 
ATOM   634  N N   . ASN A 1 252 ? 171.656 148.663 184.026 1.00 62.31  ?  241 ASN A N   1 
ATOM   635  C CA  . ASN A 1 252 ? 171.753 150.057 183.632 1.00 62.31  ?  241 ASN A CA  1 
ATOM   636  C C   . ASN A 1 252 ? 170.613 150.416 182.690 1.00 62.31  ?  241 ASN A C   1 
ATOM   637  O O   . ASN A 1 252 ? 169.831 149.568 182.261 1.00 62.31  ?  241 ASN A O   1 
ATOM   638  C CB  . ASN A 1 252 ? 173.100 150.342 182.961 1.00 62.31  ?  241 ASN A CB  1 
ATOM   639  C CG  . ASN A 1 252 ? 174.263 150.274 183.928 1.00 62.31  ?  241 ASN A CG  1 
ATOM   640  O OD1 . ASN A 1 252 ? 175.000 149.291 183.957 1.00 62.31  ?  241 ASN A OD1 1 
ATOM   641  N ND2 . ASN A 1 252 ? 174.441 151.323 184.719 1.00 62.31  ?  241 ASN A ND2 1 
ATOM   642  N N   . LEU A 1 253 ? 170.528 151.705 182.366 1.00 58.51  ?  242 LEU A N   1 
ATOM   643  C CA  . LEU A 1 253 ? 169.660 152.114 181.272 1.00 58.51  ?  242 LEU A CA  1 
ATOM   644  C C   . LEU A 1 253 ? 170.244 151.691 179.932 1.00 58.51  ?  242 LEU A C   1 
ATOM   645  O O   . LEU A 1 253 ? 169.518 151.595 178.938 1.00 58.51  ?  242 LEU A O   1 
ATOM   646  C CB  . LEU A 1 253 ? 169.444 153.621 181.312 1.00 58.51  ?  242 LEU A CB  1 
ATOM   647  C CG  . LEU A 1 253 ? 168.511 154.152 182.396 1.00 58.51  ?  242 LEU A CG  1 
ATOM   648  C CD1 . LEU A 1 253 ? 168.805 155.605 182.679 1.00 58.51  ?  242 LEU A CD1 1 
ATOM   649  C CD2 . LEU A 1 253 ? 167.070 153.984 181.978 1.00 58.51  ?  242 LEU A CD2 1 
ATOM   650  N N   . ALA A 1 254 ? 171.552 151.434 179.893 1.00 58.69  ?  243 ALA A N   1 
ATOM   651  C CA  . ALA A 1 254 ? 172.195 150.951 178.682 1.00 58.69  ?  243 ALA A CA  1 
ATOM   652  C C   . ALA A 1 254 ? 171.829 149.505 178.386 1.00 58.69  ?  243 ALA A C   1 
ATOM   653  O O   . ALA A 1 254 ? 171.650 149.138 177.220 1.00 58.69  ?  243 ALA A O   1 
ATOM   654  C CB  . ALA A 1 254 ? 173.707 151.093 178.819 1.00 58.69  ?  243 ALA A CB  1 
ATOM   655  N N   . GLY A 1 255 ? 171.729 148.671 179.422 1.00 56.52  ?  244 GLY A N   1 
ATOM   656  C CA  . GLY A 1 255 ? 171.378 147.279 179.230 1.00 56.52  ?  244 GLY A CA  1 
ATOM   657  C C   . GLY A 1 255 ? 169.925 147.058 178.890 1.00 56.52  ?  244 GLY A C   1 
ATOM   658  O O   . GLY A 1 255 ? 169.576 146.001 178.355 1.00 56.52  ?  244 GLY A O   1 
ATOM   659  N N   . LEU A 1 256 ? 169.071 148.040 179.174 1.00 51.34  ?  245 LEU A N   1 
ATOM   660  C CA  . LEU A 1 256 ? 167.654 147.936 178.857 1.00 51.34  ?  245 LEU A CA  1 
ATOM   661  C C   . LEU A 1 256 ? 167.396 147.981 177.363 1.00 51.34  ?  245 LEU A C   1 
ATOM   662  O O   . LEU A 1 256 ? 166.346 147.511 176.919 1.00 51.34  ?  245 LEU A O   1 
ATOM   663  C CB  . LEU A 1 256 ? 166.896 149.058 179.564 1.00 51.34  ?  245 LEU A CB  1 
ATOM   664  C CG  . LEU A 1 256 ? 165.385 148.954 179.743 1.00 51.34  ?  245 LEU A CG  1 
ATOM   665  C CD1 . LEU A 1 256 ? 165.046 147.758 180.578 1.00 51.34  ?  245 LEU A CD1 1 
ATOM   666  C CD2 . LEU A 1 256 ? 164.889 150.202 180.395 1.00 51.34  ?  245 LEU A CD2 1 
ATOM   667  N N   . LYS A 1 257 ? 168.340 148.511 176.588 1.00 53.85  ?  246 LYS A N   1 
ATOM   668  C CA  . LYS A 1 257 ? 168.208 148.611 175.142 1.00 53.85  ?  246 LYS A CA  1 
ATOM   669  C C   . LYS A 1 257 ? 168.161 147.250 174.465 1.00 53.85  ?  246 LYS A C   1 
ATOM   670  O O   . LYS A 1 257 ? 167.592 147.135 173.376 1.00 53.85  ?  246 LYS A O   1 
ATOM   671  C CB  . LYS A 1 257 ? 169.371 149.427 174.590 1.00 53.85  ?  246 LYS A CB  1 
ATOM   672  C CG  . LYS A 1 257 ? 169.045 150.277 173.389 1.00 53.85  ?  246 LYS A CG  1 
ATOM   673  C CD  . LYS A 1 257 ? 170.254 151.092 172.952 1.00 53.85  ?  246 LYS A CD  1 
ATOM   674  C CE  . LYS A 1 257 ? 170.747 151.973 174.082 1.00 53.85  ?  246 LYS A CE  1 
ATOM   675  N NZ  . LYS A 1 257 ? 172.155 152.395 173.893 1.00 53.85  1  246 LYS A NZ  1 
ATOM   676  N N   . GLY A 1 258 ? 168.719 146.217 175.097 1.00 52.05  ?  247 GLY A N   1 
ATOM   677  C CA  . GLY A 1 258 ? 168.739 144.903 174.490 1.00 52.05  ?  247 GLY A CA  1 
ATOM   678  C C   . GLY A 1 258 ? 167.517 144.064 174.777 1.00 52.05  ?  247 GLY A C   1 
ATOM   679  O O   . GLY A 1 258 ? 167.478 142.887 174.410 1.00 52.05  ?  247 GLY A O   1 
ATOM   680  N N   . ARG A 1 259 ? 166.525 144.625 175.458 1.00 46.91  ?  248 ARG A N   1 
ATOM   681  C CA  . ARG A 1 259 ? 165.326 143.878 175.815 1.00 46.91  ?  248 ARG A CA  1 
ATOM   682  C C   . ARG A 1 259 ? 164.108 144.252 174.983 1.00 46.91  ?  248 ARG A C   1 
ATOM   683  O O   . ARG A 1 259 ? 163.088 143.554 175.058 1.00 46.91  ?  248 ARG A O   1 
ATOM   684  C CB  . ARG A 1 259 ? 165.028 144.070 177.299 1.00 46.91  ?  248 ARG A CB  1 
ATOM   685  C CG  . ARG A 1 259 ? 166.183 143.689 178.194 1.00 46.91  ?  248 ARG A CG  1 
ATOM   686  C CD  . ARG A 1 259 ? 166.421 142.197 178.144 1.00 46.91  ?  248 ARG A CD  1 
ATOM   687  N NE  . ARG A 1 259 ? 167.394 141.763 179.143 1.00 46.91  ?  248 ARG A NE  1 
ATOM   688  C CZ  . ARG A 1 259 ? 167.849 140.520 179.251 1.00 46.91  ?  248 ARG A CZ  1 
ATOM   689  N NH1 . ARG A 1 259 ? 167.429 139.579 178.424 1.00 46.91  1  248 ARG A NH1 1 
ATOM   690  N NH2 . ARG A 1 259 ? 168.728 140.223 180.188 1.00 46.91  ?  248 ARG A NH2 1 
ATOM   691  N N   . LEU A 1 260 ? 164.204 145.300 174.162 1.00 40.38  ?  249 LEU A N   1 
ATOM   692  C CA  . LEU A 1 260 ? 163.048 145.814 173.439 1.00 40.38  ?  249 LEU A CA  1 
ATOM   693  C C   . LEU A 1 260 ? 162.552 144.877 172.351 1.00 40.38  ?  249 LEU A C   1 
ATOM   694  O O   . LEU A 1 260 ? 161.426 145.044 171.880 1.00 40.38  ?  249 LEU A O   1 
ATOM   695  C CB  . LEU A 1 260 ? 163.366 147.159 172.813 1.00 40.38  ?  249 LEU A CB  1 
ATOM   696  C CG  . LEU A 1 260 ? 164.136 148.189 173.618 1.00 40.38  ?  249 LEU A CG  1 
ATOM   697  C CD1 . LEU A 1 260 ? 164.256 149.394 172.774 1.00 40.38  ?  249 LEU A CD1 1 
ATOM   698  C CD2 . LEU A 1 260 ? 163.439 148.544 174.894 1.00 40.38  ?  249 LEU A CD2 1 
ATOM   699  N N   . ASP A 1 261 ? 163.351 143.907 171.928 1.00 41.29  ?  250 ASP A N   1 
ATOM   700  C CA  . ASP A 1 261 ? 162.815 142.904 171.023 1.00 41.29  ?  250 ASP A CA  1 
ATOM   701  C C   . ASP A 1 261 ? 162.000 141.860 171.764 1.00 41.29  ?  250 ASP A C   1 
ATOM   702  O O   . ASP A 1 261 ? 161.057 141.307 171.190 1.00 41.29  ?  250 ASP A O   1 
ATOM   703  C CB  . ASP A 1 261 ? 163.940 142.248 170.231 1.00 41.29  ?  250 ASP A CB  1 
ATOM   704  C CG  . ASP A 1 261 ? 164.380 143.086 169.052 1.00 41.29  ?  250 ASP A CG  1 
ATOM   705  O OD1 . ASP A 1 261 ? 163.502 143.624 168.351 1.00 41.29  ?  250 ASP A OD1 1 
ATOM   706  O OD2 . ASP A 1 261 ? 165.600 143.203 168.821 1.00 41.29  -1 250 ASP A OD2 1 
ATOM   707  N N   . TYR A 1 262 ? 162.332 141.579 173.028 1.00 35.65  ?  251 TYR A N   1 
ATOM   708  C CA  . TYR A 1 262 ? 161.450 140.747 173.841 1.00 35.65  ?  251 TYR A CA  1 
ATOM   709  C C   . TYR A 1 262 ? 160.164 141.479 174.157 1.00 35.65  ?  251 TYR A C   1 
ATOM   710  O O   . TYR A 1 262 ? 159.087 140.879 174.146 1.00 35.65  ?  251 TYR A O   1 
ATOM   711  C CB  . TYR A 1 262 ? 162.123 140.331 175.141 1.00 35.65  ?  251 TYR A CB  1 
ATOM   712  C CG  . TYR A 1 262 ? 161.151 139.775 176.161 1.00 35.65  ?  251 TYR A CG  1 
ATOM   713  C CD1 . TYR A 1 262 ? 160.490 138.575 175.931 1.00 35.65  ?  251 TYR A CD1 1 
ATOM   714  C CD2 . TYR A 1 262 ? 160.882 140.454 177.343 1.00 35.65  ?  251 TYR A CD2 1 
ATOM   715  C CE1 . TYR A 1 262 ? 159.604 138.067 176.850 1.00 35.65  ?  251 TYR A CE1 1 
ATOM   716  C CE2 . TYR A 1 262 ? 160.000 139.947 178.268 1.00 35.65  ?  251 TYR A CE2 1 
ATOM   717  C CZ  . TYR A 1 262 ? 159.369 138.758 178.010 1.00 35.65  ?  251 TYR A CZ  1 
ATOM   718  O OH  . TYR A 1 262 ? 158.493 138.246 178.913 1.00 35.65  ?  251 TYR A OH  1 
ATOM   719  N N   . LEU A 1 263 ? 160.263 142.771 174.464 1.00 31.05  ?  252 LEU A N   1 
ATOM   720  C CA  . LEU A 1 263 ? 159.072 143.550 174.754 1.00 31.05  ?  252 LEU A CA  1 
ATOM   721  C C   . LEU A 1 263 ? 158.172 143.704 173.540 1.00 31.05  ?  252 LEU A C   1 
ATOM   722  O O   . LEU A 1 263 ? 156.952 143.757 173.696 1.00 31.05  ?  252 LEU A O   1 
ATOM   723  C CB  . LEU A 1 263 ? 159.477 144.909 175.294 1.00 31.05  ?  252 LEU A CB  1 
ATOM   724  C CG  . LEU A 1 263 ? 160.079 144.794 176.683 1.00 31.05  ?  252 LEU A CG  1 
ATOM   725  C CD1 . LEU A 1 263 ? 160.873 146.017 177.046 1.00 31.05  ?  252 LEU A CD1 1 
ATOM   726  C CD2 . LEU A 1 263 ? 158.974 144.566 177.663 1.00 31.05  ?  252 LEU A CD2 1 
ATOM   727  N N   . SER A 1 264 ? 158.738 143.729 172.334 1.00 34.59  ?  253 SER A N   1 
ATOM   728  C CA  . SER A 1 264 ? 157.931 143.784 171.123 1.00 34.59  ?  253 SER A CA  1 
ATOM   729  C C   . SER A 1 264 ? 157.372 142.428 170.737 1.00 34.59  ?  253 SER A C   1 
ATOM   730  O O   . SER A 1 264 ? 156.531 142.350 169.840 1.00 34.59  ?  253 SER A O   1 
ATOM   731  C CB  . SER A 1 264 ? 158.756 144.338 169.982 1.00 34.59  ?  253 SER A CB  1 
ATOM   732  O OG  . SER A 1 264 ? 159.208 145.627 170.301 1.00 34.59  ?  253 SER A OG  1 
ATOM   733  N N   . SER A 1 265 ? 157.836 141.358 171.378 1.00 33.90  ?  254 SER A N   1 
ATOM   734  C CA  . SER A 1 265 ? 157.218 140.057 171.182 1.00 33.90  ?  254 SER A CA  1 
ATOM   735  C C   . SER A 1 265 ? 155.861 140.003 171.851 1.00 33.90  ?  254 SER A C   1 
ATOM   736  O O   . SER A 1 265 ? 154.963 139.296 171.383 1.00 33.90  ?  254 SER A O   1 
ATOM   737  C CB  . SER A 1 265 ? 158.119 138.967 171.746 1.00 33.90  ?  254 SER A CB  1 
ATOM   738  O OG  . SER A 1 265 ? 159.399 139.032 171.157 1.00 33.90  ?  254 SER A OG  1 
ATOM   739  N N   . LEU A 1 266 ? 155.704 140.754 172.941 1.00 26.44  ?  255 LEU A N   1 
ATOM   740  C CA  . LEU A 1 266 ? 154.466 140.824 173.696 1.00 26.44  ?  255 LEU A CA  1 
ATOM   741  C C   . LEU A 1 266 ? 153.448 141.741 173.051 1.00 26.44  ?  255 LEU A C   1 
ATOM   742  O O   . LEU A 1 266 ? 152.261 141.613 173.347 1.00 26.44  ?  255 LEU A O   1 
ATOM   743  C CB  . LEU A 1 266 ? 154.761 141.309 175.112 1.00 26.44  ?  255 LEU A CB  1 
ATOM   744  C CG  . LEU A 1 266 ? 155.862 140.582 175.868 1.00 26.44  ?  255 LEU A CG  1 
ATOM   745  C CD1 . LEU A 1 266 ? 156.145 141.265 177.172 1.00 26.44  ?  255 LEU A CD1 1 
ATOM   746  C CD2 . LEU A 1 266 ? 155.441 139.171 176.096 1.00 26.44  ?  255 LEU A CD2 1 
ATOM   747  N N   . LYS A 1 267 ? 153.903 142.626 172.163 1.00 24.85  ?  256 LYS A N   1 
ATOM   748  C CA  . LYS A 1 267 ? 153.126 143.708 171.553 1.00 24.85  ?  256 LYS A CA  1 
ATOM   749  C C   . LYS A 1 267 ? 152.547 144.648 172.605 1.00 24.85  ?  256 LYS A C   1 
ATOM   750  O O   . LYS A 1 267 ? 151.363 144.978 172.589 1.00 24.85  ?  256 LYS A O   1 
ATOM   751  C CB  . LYS A 1 267 ? 152.037 143.187 170.612 1.00 24.85  ?  256 LYS A CB  1 
ATOM   752  C CG  . LYS A 1 267 ? 152.575 142.413 169.435 1.00 24.85  ?  256 LYS A CG  1 
ATOM   753  C CD  . LYS A 1 267 ? 151.669 142.546 168.226 1.00 24.85  ?  256 LYS A CD  1 
ATOM   754  C CE  . LYS A 1 267 ? 152.276 141.896 166.979 1.00 24.85  ?  256 LYS A CE  1 
ATOM   755  N NZ  . LYS A 1 267 ? 153.593 142.452 166.564 1.00 24.85  1  256 LYS A NZ  1 
ATOM   756  N N   . VAL A 1 268 ? 153.395 145.100 173.524 1.00 20.28  ?  257 VAL A N   1 
ATOM   757  C CA  . VAL A 1 268 ? 152.967 146.126 174.455 1.00 20.28  ?  257 VAL A CA  1 
ATOM   758  C C   . VAL A 1 268 ? 153.181 147.494 173.818 1.00 20.28  ?  257 VAL A C   1 
ATOM   759  O O   . VAL A 1 268 ? 154.124 147.716 173.053 1.00 20.28  ?  257 VAL A O   1 
ATOM   760  C CB  . VAL A 1 268 ? 153.688 145.989 175.810 1.00 20.28  ?  257 VAL A CB  1 
ATOM   761  C CG1 . VAL A 1 268 ? 153.459 144.618 176.369 1.00 20.28  ?  257 VAL A CG1 1 
ATOM   762  C CG2 . VAL A 1 268 ? 155.158 146.254 175.712 1.00 20.28  ?  257 VAL A CG2 1 
ATOM   763  N N   . LYS A 1 269 ? 152.258 148.407 174.076 1.00 19.13  ?  258 LYS A N   1 
ATOM   764  C CA  . LYS A 1 269 ? 152.292 149.701 173.427 1.00 19.13  ?  258 LYS A CA  1 
ATOM   765  C C   . LYS A 1 269 ? 153.006 150.752 174.244 1.00 19.13  ?  258 LYS A C   1 
ATOM   766  O O   . LYS A 1 269 ? 153.309 151.820 173.716 1.00 19.13  ?  258 LYS A O   1 
ATOM   767  C CB  . LYS A 1 269 ? 150.875 150.173 173.117 1.00 19.13  ?  258 LYS A CB  1 
ATOM   768  C CG  . LYS A 1 269 ? 150.075 149.212 172.298 1.00 19.13  ?  258 LYS A CG  1 
ATOM   769  C CD  . LYS A 1 269 ? 150.720 148.934 170.979 1.00 19.13  ?  258 LYS A CD  1 
ATOM   770  C CE  . LYS A 1 269 ? 150.140 147.689 170.347 1.00 19.13  ?  258 LYS A CE  1 
ATOM   771  N NZ  . LYS A 1 269 ? 151.085 147.049 169.395 1.00 19.13  1  258 LYS A NZ  1 
ATOM   772  N N   . GLY A 1 270 ? 153.281 150.485 175.506 1.00 15.46  ?  259 GLY A N   1 
ATOM   773  C CA  . GLY A 1 270 ? 153.968 151.449 176.332 1.00 15.46  ?  259 GLY A CA  1 
ATOM   774  C C   . GLY A 1 270 ? 154.684 150.755 177.459 1.00 15.46  ?  259 GLY A C   1 
ATOM   775  O O   . GLY A 1 270 ? 154.413 149.602 177.780 1.00 15.46  ?  259 GLY A O   1 
ATOM   776  N N   . LEU A 1 271 ? 155.592 151.495 178.074 1.00 16.50  ?  260 LEU A N   1 
ATOM   777  C CA  . LEU A 1 271 ? 156.529 150.972 179.051 1.00 16.50  ?  260 LEU A CA  1 
ATOM   778  C C   . LEU A 1 271 ? 156.617 151.982 180.175 1.00 16.50  ?  260 LEU A C   1 
ATOM   779  O O   . LEU A 1 271 ? 156.776 153.172 179.913 1.00 16.50  ?  260 LEU A O   1 
ATOM   780  C CB  . LEU A 1 271 ? 157.891 150.770 178.401 1.00 16.50  ?  260 LEU A CB  1 
ATOM   781  C CG  . LEU A 1 271 ? 158.942 149.789 178.884 1.00 16.50  ?  260 LEU A CG  1 
ATOM   782  C CD1 . LEU A 1 271 ? 159.775 149.477 177.691 1.00 16.50  ?  260 LEU A CD1 1 
ATOM   783  C CD2 . LEU A 1 271 ? 159.810 150.376 179.970 1.00 16.50  ?  260 LEU A CD2 1 
ATOM   784  N N   . VAL A 1 272 ? 156.524 151.525 181.413 1.00 15.91  ?  261 VAL A N   1 
ATOM   785  C CA  . VAL A 1 272 ? 156.528 152.411 182.565 1.00 15.91  ?  261 VAL A CA  1 
ATOM   786  C C   . VAL A 1 272 ? 157.833 152.185 183.312 1.00 15.91  ?  261 VAL A C   1 
ATOM   787  O O   . VAL A 1 272 ? 157.943 151.285 184.134 1.00 15.91  ?  261 VAL A O   1 
ATOM   788  C CB  . VAL A 1 272 ? 155.307 152.189 183.457 1.00 15.91  ?  261 VAL A CB  1 
ATOM   789  C CG1 . VAL A 1 272 ? 155.224 153.267 184.489 1.00 15.91  ?  261 VAL A CG1 1 
ATOM   790  C CG2 . VAL A 1 272 ? 154.046 152.181 182.627 1.00 15.91  ?  261 VAL A CG2 1 
ATOM   791  N N   . LEU A 1 273 ? 158.825 153.019 183.037 1.00 21.57  ?  262 LEU A N   1 
ATOM   792  C CA  . LEU A 1 273 ? 160.109 152.936 183.712 1.00 21.57  ?  262 LEU A CA  1 
ATOM   793  C C   . LEU A 1 273 ? 160.030 153.508 185.106 1.00 21.57  ?  262 LEU A C   1 
ATOM   794  O O   . LEU A 1 273 ? 159.487 154.589 185.306 1.00 21.57  ?  262 LEU A O   1 
ATOM   795  C CB  . LEU A 1 273 ? 161.171 153.703 182.946 1.00 21.57  ?  262 LEU A CB  1 
ATOM   796  C CG  . LEU A 1 273 ? 162.103 152.889 182.088 1.00 21.57  ?  262 LEU A CG  1 
ATOM   797  C CD1 . LEU A 1 273 ? 163.051 153.846 181.454 1.00 21.57  ?  262 LEU A CD1 1 
ATOM   798  C CD2 . LEU A 1 273 ? 162.838 151.923 182.958 1.00 21.57  ?  262 LEU A CD2 1 
ATOM   799  N N   . GLY A 1 274 ? 160.662 152.822 186.056 1.00 24.12  ?  263 GLY A N   1 
ATOM   800  C CA  . GLY A 1 274 ? 160.568 153.178 187.441 1.00 24.12  ?  263 GLY A CA  1 
ATOM   801  C C   . GLY A 1 274 ? 161.356 154.417 187.745 1.00 24.12  ?  263 GLY A C   1 
ATOM   802  O O   . GLY A 1 274 ? 161.981 155.006 186.866 1.00 24.12  ?  263 GLY A O   1 
ATOM   803  N N   . PRO A 1 275 ? 161.305 154.853 188.992 1.00 27.93  ?  264 PRO A N   1 
ATOM   804  C CA  . PRO A 1 275 ? 161.972 156.104 189.351 1.00 27.93  ?  264 PRO A CA  1 
ATOM   805  C C   . PRO A 1 275 ? 163.485 155.977 189.297 1.00 27.93  ?  264 PRO A C   1 
ATOM   806  O O   . PRO A 1 275 ? 164.075 155.106 189.941 1.00 27.93  ?  264 PRO A O   1 
ATOM   807  C CB  . PRO A 1 275 ? 161.464 156.379 190.769 1.00 27.93  ?  264 PRO A CB  1 
ATOM   808  C CG  . PRO A 1 275 ? 160.314 155.518 190.954 1.00 27.93  ?  264 PRO A CG  1 
ATOM   809  C CD  . PRO A 1 275 ? 160.544 154.315 190.121 1.00 27.93  ?  264 PRO A CD  1 
ATOM   810  N N   . ILE A 1 276 ? 164.116 156.829 188.497 1.00 40.31  ?  265 ILE A N   1 
ATOM   811  C CA  . ILE A 1 276 ? 165.532 156.724 188.203 1.00 40.31  ?  265 ILE A CA  1 
ATOM   812  C C   . ILE A 1 276 ? 166.315 157.897 188.766 1.00 40.31  ?  265 ILE A C   1 
ATOM   813  O O   . ILE A 1 276 ? 167.540 157.916 188.672 1.00 40.31  ?  265 ILE A O   1 
ATOM   814  C CB  . ILE A 1 276 ? 165.779 156.585 186.693 1.00 40.31  ?  265 ILE A CB  1 
ATOM   815  C CG1 . ILE A 1 276 ? 165.224 157.786 185.946 1.00 40.31  ?  265 ILE A CG1 1 
ATOM   816  C CG2 . ILE A 1 276 ? 165.172 155.321 186.166 1.00 40.31  ?  265 ILE A CG2 1 
ATOM   817  C CD1 . ILE A 1 276 ? 165.482 157.743 184.491 1.00 40.31  ?  265 ILE A CD1 1 
ATOM   818  N N   . HIS A 1 277 ? 165.642 158.873 189.357 1.00 46.41  ?  266 HIS A N   1 
ATOM   819  C CA  . HIS A 1 277 ? 166.302 160.078 189.829 1.00 46.41  ?  266 HIS A CA  1 
ATOM   820  C C   . HIS A 1 277 ? 166.991 159.832 191.163 1.00 46.41  ?  266 HIS A C   1 
ATOM   821  O O   . HIS A 1 277 ? 166.841 158.782 191.788 1.00 46.41  ?  266 HIS A O   1 
ATOM   822  C CB  . HIS A 1 277 ? 165.295 161.209 189.954 1.00 46.41  ?  266 HIS A CB  1 
ATOM   823  C CG  . HIS A 1 277 ? 164.182 160.923 190.910 1.00 46.41  ?  266 HIS A CG  1 
ATOM   824  N ND1 . HIS A 1 277 ? 163.005 160.328 190.521 1.00 46.41  ?  266 HIS A ND1 1 
ATOM   825  C CD2 . HIS A 1 277 ? 164.055 161.179 192.231 1.00 46.41  ?  266 HIS A CD2 1 
ATOM   826  C CE1 . HIS A 1 277 ? 162.206 160.217 191.564 1.00 46.41  ?  266 HIS A CE1 1 
ATOM   827  N NE2 . HIS A 1 277 ? 162.817 160.732 192.614 1.00 46.41  ?  266 HIS A NE2 1 
ATOM   828  N N   . LYS A 1 278 ? 167.740 160.827 191.625 1.00 55.21  ?  267 LYS A N   1 
ATOM   829  C CA  . LYS A 1 278 ? 168.529 160.684 192.842 1.00 55.21  ?  267 LYS A CA  1 
ATOM   830  C C   . LYS A 1 278 ? 167.656 160.981 194.056 1.00 55.21  ?  267 LYS A C   1 
ATOM   831  O O   . LYS A 1 278 ? 167.212 162.112 194.264 1.00 55.21  ?  267 LYS A O   1 
ATOM   832  C CB  . LYS A 1 278 ? 169.771 161.572 192.803 1.00 55.21  ?  267 LYS A CB  1 
ATOM   833  C CG  . LYS A 1 278 ? 169.578 162.986 192.322 1.00 55.21  ?  267 LYS A CG  1 
ATOM   834  C CD  . LYS A 1 278 ? 170.870 163.760 192.450 1.00 55.21  ?  267 LYS A CD  1 
ATOM   835  C CE  . LYS A 1 278 ? 171.331 163.851 193.898 1.00 55.21  ?  267 LYS A CE  1 
ATOM   836  N NZ  . LYS A 1 278 ? 170.381 164.575 194.774 1.00 55.21  1  267 LYS A NZ  1 
ATOM   837  N N   . ASN A 1 279 ? 167.398 159.950 194.846 1.00 53.56  ?  268 ASN A N   1 
ATOM   838  C CA  . ASN A 1 279 ? 166.733 160.071 196.131 1.00 53.56  ?  268 ASN A CA  1 
ATOM   839  C C   . ASN A 1 279 ? 167.675 159.516 197.176 1.00 53.56  ?  268 ASN A C   1 
ATOM   840  O O   . ASN A 1 279 ? 168.241 158.437 196.992 1.00 53.56  ?  268 ASN A O   1 
ATOM   841  C CB  . ASN A 1 279 ? 165.422 159.302 196.172 1.00 53.56  ?  268 ASN A CB  1 
ATOM   842  C CG  . ASN A 1 279 ? 164.661 159.501 197.460 1.00 53.56  ?  268 ASN A CG  1 
ATOM   843  O OD1 . ASN A 1 279 ? 164.982 160.348 198.269 1.00 53.56  ?  268 ASN A OD1 1 
ATOM   844  N ND2 . ASN A 1 279 ? 163.692 158.653 197.687 1.00 53.56  ?  268 ASN A ND2 1 
ATOM   845  N N   . GLN A 1 280 ? 167.879 160.269 198.247 1.00 60.91  ?  269 GLN A N   1 
ATOM   846  C CA  . GLN A 1 280 ? 168.669 159.743 199.355 1.00 60.91  ?  269 GLN A CA  1 
ATOM   847  C C   . GLN A 1 280 ? 167.764 159.030 200.353 1.00 60.91  ?  269 GLN A C   1 
ATOM   848  O O   . GLN A 1 280 ? 167.736 157.800 200.431 1.00 60.91  ?  269 GLN A O   1 
ATOM   849  C CB  . GLN A 1 280 ? 169.450 160.875 200.040 1.00 60.91  ?  269 GLN A CB  1 
ATOM   850  C CG  . GLN A 1 280 ? 170.537 161.627 199.223 1.00 60.91  ?  269 GLN A CG  1 
ATOM   851  C CD  . GLN A 1 280 ? 170.032 162.363 197.982 1.00 60.91  ?  269 GLN A CD  1 
ATOM   852  O OE1 . GLN A 1 280 ? 169.040 163.089 198.040 1.00 60.91  ?  269 GLN A OE1 1 
ATOM   853  N NE2 . GLN A 1 280 ? 170.703 162.157 196.854 1.00 60.91  ?  269 GLN A NE2 1 
ATOM   854  N N   . LYS A 1 281 ? 166.986 159.812 201.085 1.00 61.66  ?  270 LYS A N   1 
ATOM   855  C CA  . LYS A 1 281 ? 166.054 159.368 202.106 1.00 61.66  ?  270 LYS A CA  1 
ATOM   856  C C   . LYS A 1 281 ? 165.214 160.596 202.400 1.00 61.66  ?  270 LYS A C   1 
ATOM   857  O O   . LYS A 1 281 ? 165.226 161.543 201.611 1.00 61.66  ?  270 LYS A O   1 
ATOM   858  C CB  . LYS A 1 281 ? 166.755 158.845 203.357 1.00 61.66  ?  270 LYS A CB  1 
ATOM   859  C CG  . LYS A 1 281 ? 166.008 157.724 204.058 1.00 61.66  ?  270 LYS A CG  1 
ATOM   860  C CD  . LYS A 1 281 ? 165.648 156.600 203.116 1.00 61.66  ?  270 LYS A CD  1 
ATOM   861  C CE  . LYS A 1 281 ? 166.795 155.638 202.961 1.00 61.66  ?  270 LYS A CE  1 
ATOM   862  N NZ  . LYS A 1 281 ? 166.385 154.427 202.219 1.00 61.66  1  270 LYS A NZ  1 
ATOM   863  N N   . ASP A 1 282 ? 164.488 160.578 203.515 1.00 67.62  ?  271 ASP A N   1 
ATOM   864  C CA  . ASP A 1 282 ? 163.589 161.668 203.925 1.00 67.62  ?  271 ASP A CA  1 
ATOM   865  C C   . ASP A 1 282 ? 164.080 163.123 203.819 1.00 67.62  ?  271 ASP A C   1 
ATOM   866  O O   . ASP A 1 282 ? 163.300 164.051 204.033 1.00 67.62  ?  271 ASP A O   1 
ATOM   867  C CB  . ASP A 1 282 ? 163.076 161.411 205.347 1.00 67.62  ?  271 ASP A CB  1 
ATOM   868  C CG  . ASP A 1 282 ? 162.464 160.033 205.505 1.00 67.62  ?  271 ASP A CG  1 
ATOM   869  O OD1 . ASP A 1 282 ? 162.138 159.404 204.476 1.00 67.62  ?  271 ASP A OD1 1 
ATOM   870  O OD2 . ASP A 1 282 ? 162.309 159.578 206.658 1.00 67.62  -1 271 ASP A OD2 1 
ATOM   871  N N   . ASP A 1 283 ? 165.352 163.327 203.498 1.00 71.58  ?  272 ASP A N   1 
ATOM   872  C CA  . ASP A 1 283 ? 165.902 164.668 203.385 1.00 71.58  ?  272 ASP A CA  1 
ATOM   873  C C   . ASP A 1 283 ? 165.177 165.158 202.132 1.00 71.58  ?  272 ASP A C   1 
ATOM   874  O O   . ASP A 1 283 ? 165.311 164.561 201.064 1.00 71.58  ?  272 ASP A O   1 
ATOM   875  C CB  . ASP A 1 283 ? 167.409 164.625 203.156 1.00 71.58  ?  272 ASP A CB  1 
ATOM   876  C CG  . ASP A 1 283 ? 168.004 166.001 202.932 1.00 71.58  ?  272 ASP A CG  1 
ATOM   877  O OD1 . ASP A 1 283 ? 167.237 166.940 202.633 1.00 71.58  ?  272 ASP A OD1 1 
ATOM   878  O OD2 . ASP A 1 283 ? 169.239 166.143 203.053 1.00 71.58  -1 272 ASP A OD2 1 
ATOM   879  N N   . VAL A 1 284 ? 164.393 166.224 202.261 1.00 67.65  ?  273 VAL A N   1 
ATOM   880  C CA  . VAL A 1 284 ? 163.586 166.730 201.163 1.00 67.65  ?  273 VAL A CA  1 
ATOM   881  C C   . VAL A 1 284 ? 164.374 167.696 200.282 1.00 67.65  ?  273 VAL A C   1 
ATOM   882  O O   . VAL A 1 284 ? 164.154 167.754 199.069 1.00 67.65  ?  273 VAL A O   1 
ATOM   883  C CB  . VAL A 1 284 ? 162.333 167.386 201.760 1.00 67.65  ?  273 VAL A CB  1 
ATOM   884  C CG1 . VAL A 1 284 ? 161.389 167.892 200.692 1.00 67.65  ?  273 VAL A CG1 1 
ATOM   885  C CG2 . VAL A 1 284 ? 161.639 166.409 202.661 1.00 67.65  ?  273 VAL A CG2 1 
ATOM   886  N N   . ALA A 1 285 ? 165.323 168.428 200.866 1.00 71.22  ?  274 ALA A N   1 
ATOM   887  C CA  . ALA A 1 285 ? 166.028 169.468 200.127 1.00 71.22  ?  274 ALA A CA  1 
ATOM   888  C C   . ALA A 1 285 ? 167.171 168.913 199.285 1.00 71.22  ?  274 ALA A C   1 
ATOM   889  O O   . ALA A 1 285 ? 167.725 169.639 198.454 1.00 71.22  ?  274 ALA A O   1 
ATOM   890  C CB  . ALA A 1 285 ? 166.556 170.526 201.096 1.00 71.22  ?  274 ALA A CB  1 
ATOM   891  N N   . GLN A 1 286 ? 167.551 167.654 199.475 1.00 67.79  ?  275 GLN A N   1 
ATOM   892  C CA  . GLN A 1 286 ? 168.666 167.126 198.705 1.00 67.79  ?  275 GLN A CA  1 
ATOM   893  C C   . GLN A 1 286 ? 168.233 166.355 197.466 1.00 67.79  ?  275 GLN A C   1 
ATOM   894  O O   . GLN A 1 286 ? 168.976 166.345 196.480 1.00 67.79  ?  275 GLN A O   1 
ATOM   895  C CB  . GLN A 1 286 ? 169.557 166.238 199.577 1.00 67.79  ?  275 GLN A CB  1 
ATOM   896  C CG  . GLN A 1 286 ? 170.986 166.157 199.064 1.00 67.79  ?  275 GLN A CG  1 
ATOM   897  C CD  . GLN A 1 286 ? 171.732 164.953 199.565 1.00 67.79  ?  275 GLN A CD  1 
ATOM   898  O OE1 . GLN A 1 286 ? 172.429 164.283 198.808 1.00 67.79  ?  275 GLN A OE1 1 
ATOM   899  N NE2 . GLN A 1 286 ? 171.584 164.659 200.849 1.00 67.79  ?  275 GLN A NE2 1 
ATOM   900  N N   . THR A 1 287 ? 167.061 165.722 197.482 1.00 65.31  ?  276 THR A N   1 
ATOM   901  C CA  . THR A 1 287 ? 166.612 164.953 196.327 1.00 65.31  ?  276 THR A CA  1 
ATOM   902  C C   . THR A 1 287 ? 166.168 165.874 195.206 1.00 65.31  ?  276 THR A C   1 
ATOM   903  O O   . THR A 1 287 ? 165.412 166.823 195.428 1.00 65.31  ?  276 THR A O   1 
ATOM   904  C CB  . THR A 1 287 ? 165.463 164.029 196.701 1.00 65.31  ?  276 THR A CB  1 
ATOM   905  O OG1 . THR A 1 287 ? 164.239 164.769 196.720 1.00 65.31  ?  276 THR A OG1 1 
ATOM   906  C CG2 . THR A 1 287 ? 165.701 163.458 198.041 1.00 65.31  ?  276 THR A CG2 1 
ATOM   907  N N   . ASP A 1 288 ? 166.620 165.568 193.993 1.00 61.79  ?  277 ASP A N   1 
ATOM   908  C CA  . ASP A 1 288 ? 166.350 166.376 192.814 1.00 61.79  ?  277 ASP A CA  1 
ATOM   909  C C   . ASP A 1 288 ? 165.747 165.474 191.753 1.00 61.79  ?  277 ASP A C   1 
ATOM   910  O O   . ASP A 1 288 ? 166.301 164.412 191.464 1.00 61.79  ?  277 ASP A O   1 
ATOM   911  C CB  . ASP A 1 288 ? 167.637 167.026 192.305 1.00 61.79  ?  277 ASP A CB  1 
ATOM   912  C CG  . ASP A 1 288 ? 167.386 168.286 191.512 1.00 61.79  ?  277 ASP A CG  1 
ATOM   913  O OD1 . ASP A 1 288 ? 166.217 168.707 191.405 1.00 61.79  ?  277 ASP A OD1 1 
ATOM   914  O OD2 . ASP A 1 288 ? 168.364 168.856 190.989 1.00 61.79  -1 277 ASP A OD2 1 
ATOM   915  N N   . LEU A 1 289 ? 164.622 165.887 191.174 1.00 52.98  ?  278 LEU A N   1 
ATOM   916  C CA  . LEU A 1 289 ? 163.964 165.047 190.184 1.00 52.98  ?  278 LEU A CA  1 
ATOM   917  C C   . LEU A 1 289 ? 164.450 165.305 188.768 1.00 52.98  ?  278 LEU A C   1 
ATOM   918  O O   . LEU A 1 289 ? 163.913 164.709 187.833 1.00 52.98  ?  278 LEU A O   1 
ATOM   919  C CB  . LEU A 1 289 ? 162.445 165.224 190.226 1.00 52.98  ?  278 LEU A CB  1 
ATOM   920  C CG  . LEU A 1 289 ? 161.607 165.153 191.510 1.00 52.98  ?  278 LEU A CG  1 
ATOM   921  C CD1 . LEU A 1 289 ? 160.184 164.842 191.156 1.00 52.98  ?  278 LEU A CD1 1 
ATOM   922  C CD2 . LEU A 1 289 ? 162.094 164.137 192.497 1.00 52.98  ?  278 LEU A CD2 1 
ATOM   923  N N   . LEU A 1 290 ? 165.440 166.172 188.575 1.00 56.45  ?  279 LEU A N   1 
ATOM   924  C CA  . LEU A 1 290 ? 165.930 166.468 187.234 1.00 56.45  ?  279 LEU A CA  1 
ATOM   925  C C   . LEU A 1 290 ? 167.208 165.725 186.877 1.00 56.45  ?  279 LEU A C   1 
ATOM   926  O O   . LEU A 1 290 ? 167.572 165.677 185.698 1.00 56.45  ?  279 LEU A O   1 
ATOM   927  C CB  . LEU A 1 290 ? 166.178 167.970 187.077 1.00 56.45  ?  279 LEU A CB  1 
ATOM   928  C CG  . LEU A 1 290 ? 165.099 168.900 187.613 1.00 56.45  ?  279 LEU A CG  1 
ATOM   929  C CD1 . LEU A 1 290 ? 165.530 170.332 187.466 1.00 56.45  ?  279 LEU A CD1 1 
ATOM   930  C CD2 . LEU A 1 290 ? 163.825 168.674 186.866 1.00 56.45  ?  279 LEU A CD2 1 
ATOM   931  N N   . GLN A 1 291 ? 167.893 165.152 187.857 1.00 58.60  ?  280 GLN A N   1 
ATOM   932  C CA  . GLN A 1 291 ? 169.240 164.637 187.690 1.00 58.60  ?  280 GLN A CA  1 
ATOM   933  C C   . GLN A 1 291 ? 169.267 163.152 188.021 1.00 58.60  ?  280 GLN A C   1 
ATOM   934  O O   . GLN A 1 291 ? 168.790 162.746 189.082 1.00 58.60  ?  280 GLN A O   1 
ATOM   935  C CB  . GLN A 1 291 ? 170.192 165.415 188.594 1.00 58.60  ?  280 GLN A CB  1 
ATOM   936  C CG  . GLN A 1 291 ? 171.641 165.066 188.467 1.00 58.60  ?  280 GLN A CG  1 
ATOM   937  C CD  . GLN A 1 291 ? 172.385 165.461 189.705 1.00 58.60  ?  280 GLN A CD  1 
ATOM   938  O OE1 . GLN A 1 291 ? 171.900 166.270 190.493 1.00 58.60  ?  280 GLN A OE1 1 
ATOM   939  N NE2 . GLN A 1 291 ? 173.560 164.878 189.905 1.00 58.60  ?  280 GLN A NE2 1 
ATOM   940  N N   . ILE A 1 292 ? 169.839 162.353 187.127 1.00 55.84  ?  281 ILE A N   1 
ATOM   941  C CA  . ILE A 1 292 ? 169.757 160.900 187.224 1.00 55.84  ?  281 ILE A CA  1 
ATOM   942  C C   . ILE A 1 292 ? 170.732 160.389 188.273 1.00 55.84  ?  281 ILE A C   1 
ATOM   943  O O   . ILE A 1 292 ? 171.857 160.882 188.392 1.00 55.84  ?  281 ILE A O   1 
ATOM   944  C CB  . ILE A 1 292 ? 170.027 160.251 185.856 1.00 55.84  ?  281 ILE A CB  1 
ATOM   945  C CG1 . ILE A 1 292 ? 169.152 160.886 184.798 1.00 55.84  ?  281 ILE A CG1 1 
ATOM   946  C CG2 . ILE A 1 292 ? 169.706 158.772 185.872 1.00 55.84  ?  281 ILE A CG2 1 
ATOM   947  C CD1 . ILE A 1 292 ? 167.705 160.707 185.079 1.00 55.84  ?  281 ILE A CD1 1 
ATOM   948  N N   . ASP A 1 293 ? 170.275 159.422 189.062 1.00 60.34  ?  282 ASP A N   1 
ATOM   949  C CA  . ASP A 1 293 ? 171.147 158.612 189.893 1.00 60.34  ?  282 ASP A CA  1 
ATOM   950  C C   . ASP A 1 293 ? 172.151 157.878 189.012 1.00 60.34  ?  282 ASP A C   1 
ATOM   951  O O   . ASP A 1 293 ? 171.749 157.237 188.034 1.00 60.34  ?  282 ASP A O   1 
ATOM   952  C CB  . ASP A 1 293 ? 170.301 157.610 190.664 1.00 60.34  ?  282 ASP A CB  1 
ATOM   953  C CG  . ASP A 1 293 ? 171.037 156.965 191.805 1.00 60.34  ?  282 ASP A CG  1 
ATOM   954  O OD1 . ASP A 1 293 ? 171.911 157.615 192.407 1.00 60.34  ?  282 ASP A OD1 1 
ATOM   955  O OD2 . ASP A 1 293 ? 170.731 155.795 192.110 1.00 60.34  -1 282 ASP A OD2 1 
ATOM   956  N N   . PRO A 1 294 ? 173.455 157.948 189.311 1.00 60.88  ?  283 PRO A N   1 
ATOM   957  C CA  . PRO A 1 294 ? 174.451 157.324 188.428 1.00 60.88  ?  283 PRO A CA  1 
ATOM   958  C C   . PRO A 1 294 ? 174.428 155.802 188.421 1.00 60.88  ?  283 PRO A C   1 
ATOM   959  O O   . PRO A 1 294 ? 175.049 155.205 187.534 1.00 60.88  ?  283 PRO A O   1 
ATOM   960  C CB  . PRO A 1 294 ? 175.777 157.849 188.981 1.00 60.88  ?  283 PRO A CB  1 
ATOM   961  C CG  . PRO A 1 294 ? 175.474 158.241 190.370 1.00 60.88  ?  283 PRO A CG  1 
ATOM   962  C CD  . PRO A 1 294 ? 174.099 158.776 190.340 1.00 60.88  ?  283 PRO A CD  1 
ATOM   963  N N   . ASN A 1 295 ? 173.706 155.158 189.339 1.00 62.43  ?  284 ASN A N   1 
ATOM   964  C CA  . ASN A 1 295 ? 173.567 153.709 189.341 1.00 62.43  ?  284 ASN A CA  1 
ATOM   965  C C   . ASN A 1 295 ? 172.662 153.183 188.236 1.00 62.43  ?  284 ASN A C   1 
ATOM   966  O O   . ASN A 1 295 ? 172.532 151.964 188.104 1.00 62.43  ?  284 ASN A O   1 
ATOM   967  C CB  . ASN A 1 295 ? 173.031 153.233 190.688 1.00 62.43  ?  284 ASN A CB  1 
ATOM   968  C CG  . ASN A 1 295 ? 173.937 153.607 191.837 1.00 62.43  ?  284 ASN A CG  1 
ATOM   969  O OD1 . ASN A 1 295 ? 175.055 154.072 191.632 1.00 62.43  ?  284 ASN A OD1 1 
ATOM   970  N ND2 . ASN A 1 295 ? 173.451 153.420 193.060 1.00 62.43  ?  284 ASN A ND2 1 
ATOM   971  N N   . PHE A 1 296 ? 172.011 154.051 187.463 1.00 56.83  ?  285 PHE A N   1 
ATOM   972  C CA  . PHE A 1 296 ? 171.245 153.614 186.305 1.00 56.83  ?  285 PHE A CA  1 
ATOM   973  C C   . PHE A 1 296 ? 171.880 154.018 184.982 1.00 56.83  ?  285 PHE A C   1 
ATOM   974  O O   . PHE A 1 296 ? 171.626 153.363 183.967 1.00 56.83  ?  285 PHE A O   1 
ATOM   975  C CB  . PHE A 1 296 ? 169.812 154.163 186.371 1.00 56.83  ?  285 PHE A CB  1 
ATOM   976  C CG  . PHE A 1 296 ? 169.087 153.802 187.629 1.00 56.83  ?  285 PHE A CG  1 
ATOM   977  C CD1 . PHE A 1 296 ? 168.486 152.567 187.764 1.00 56.83  ?  285 PHE A CD1 1 
ATOM   978  C CD2 . PHE A 1 296 ? 169.021 154.693 188.683 1.00 56.83  ?  285 PHE A CD2 1 
ATOM   979  C CE1 . PHE A 1 296 ? 167.835 152.229 188.925 1.00 56.83  ?  285 PHE A CE1 1 
ATOM   980  C CE2 . PHE A 1 296 ? 168.374 154.360 189.842 1.00 56.83  ?  285 PHE A CE2 1 
ATOM   981  C CZ  . PHE A 1 296 ? 167.777 153.127 189.962 1.00 56.83  ?  285 PHE A CZ  1 
ATOM   982  N N   . GLY A 1 297 ? 172.698 155.050 184.973 1.00 62.09  ?  286 GLY A N   1 
ATOM   983  C CA  . GLY A 1 297 ? 173.361 155.496 183.768 1.00 62.09  ?  286 GLY A CA  1 
ATOM   984  C C   . GLY A 1 297 ? 173.614 156.996 183.834 1.00 62.09  ?  286 GLY A C   1 
ATOM   985  O O   . GLY A 1 297 ? 173.751 157.563 184.919 1.00 62.09  ?  286 GLY A O   1 
ATOM   986  N N   . SER A 1 298 ? 173.664 157.617 182.663 1.00 68.73  ?  287 SER A N   1 
ATOM   987  C CA  . SER A 1 298 ? 173.863 159.054 182.568 1.00 68.73  ?  287 SER A CA  1 
ATOM   988  C C   . SER A 1 298 ? 172.726 159.621 181.728 1.00 68.73  ?  287 SER A C   1 
ATOM   989  O O   . SER A 1 298 ? 171.725 158.952 181.467 1.00 68.73  ?  287 SER A O   1 
ATOM   990  C CB  . SER A 1 298 ? 175.247 159.385 181.997 1.00 68.73  ?  287 SER A CB  1 
ATOM   991  O OG  . SER A 1 298 ? 175.452 160.787 181.919 1.00 68.73  ?  287 SER A OG  1 
ATOM   992  N N   . LYS A 1 299 ? 172.856 160.873 181.330 1.00 66.02  ?  288 LYS A N   1 
ATOM   993  C CA  . LYS A 1 299 ? 171.793 161.546 180.609 1.00 66.02  ?  288 LYS A CA  1 
ATOM   994  C C   . LYS A 1 299 ? 171.682 161.105 179.154 1.00 66.02  ?  288 LYS A C   1 
ATOM   995  O O   . LYS A 1 299 ? 170.585 161.165 178.589 1.00 66.02  ?  288 LYS A O   1 
ATOM   996  C CB  . LYS A 1 299 ? 172.009 163.053 180.687 1.00 66.02  ?  288 LYS A CB  1 
ATOM   997  C CG  . LYS A 1 299 ? 170.809 163.884 180.321 1.00 66.02  ?  288 LYS A CG  1 
ATOM   998  C CD  . LYS A 1 299 ? 169.787 163.940 181.426 1.00 66.02  ?  288 LYS A CD  1 
ATOM   999  C CE  . LYS A 1 299 ? 168.518 164.581 180.905 1.00 66.02  ?  288 LYS A CE  1 
ATOM   1000 N NZ  . LYS A 1 299 ? 168.754 165.961 180.406 1.00 66.02  1  288 LYS A NZ  1 
ATOM   1001 N N   . GLU A 1 300 ? 172.766 160.637 178.537 1.00 68.25  ?  289 GLU A N   1 
ATOM   1002 C CA  . GLU A 1 300 ? 172.761 160.393 177.098 1.00 68.25  ?  289 GLU A CA  1 
ATOM   1003 C C   . GLU A 1 300 ? 172.346 158.983 176.708 1.00 68.25  ?  289 GLU A C   1 
ATOM   1004 O O   . GLU A 1 300 ? 171.784 158.796 175.623 1.00 68.25  ?  289 GLU A O   1 
ATOM   1005 C CB  . GLU A 1 300 ? 174.132 160.702 176.490 1.00 68.25  ?  289 GLU A CB  1 
ATOM   1006 C CG  . GLU A 1 300 ? 174.454 162.180 176.427 1.00 68.25  ?  289 GLU A CG  1 
ATOM   1007 C CD  . GLU A 1 300 ? 175.070 162.702 177.706 1.00 68.25  ?  289 GLU A CD  1 
ATOM   1008 O OE1 . GLU A 1 300 ? 175.361 161.887 178.607 1.00 68.25  ?  289 GLU A OE1 1 
ATOM   1009 O OE2 . GLU A 1 300 ? 175.252 163.931 177.813 1.00 68.25  -1 289 GLU A OE2 1 
ATOM   1010 N N   . ASP A 1 301 ? 172.598 157.972 177.540 1.00 66.01  ?  290 ASP A N   1 
ATOM   1011 C CA  . ASP A 1 301 ? 172.059 156.662 177.193 1.00 66.01  ?  290 ASP A CA  1 
ATOM   1012 C C   . ASP A 1 301 ? 170.567 156.566 177.500 1.00 66.01  ?  290 ASP A C   1 
ATOM   1013 O O   . ASP A 1 301 ? 169.890 155.703 176.939 1.00 66.01  ?  290 ASP A O   1 
ATOM   1014 C CB  . ASP A 1 301 ? 172.853 155.534 177.867 1.00 66.01  ?  290 ASP A CB  1 
ATOM   1015 C CG  . ASP A 1 301 ? 173.064 155.762 179.336 1.00 66.01  ?  290 ASP A CG  1 
ATOM   1016 O OD1 . ASP A 1 301 ? 172.635 156.820 179.820 1.00 66.01  ?  290 ASP A OD1 1 
ATOM   1017 O OD2 . ASP A 1 301 ? 173.672 154.896 180.002 1.00 66.01  -1 290 ASP A OD2 1 
ATOM   1018 N N   . PHE A 1 302 ? 170.033 157.469 178.329 1.00 59.68  ?  291 PHE A N   1 
ATOM   1019 C CA  . PHE A 1 302 ? 168.585 157.642 178.407 1.00 59.68  ?  291 PHE A CA  1 
ATOM   1020 C C   . PHE A 1 302 ? 168.017 158.121 177.077 1.00 59.68  ?  291 PHE A C   1 
ATOM   1021 O O   . PHE A 1 302 ? 166.996 157.609 176.608 1.00 59.68  ?  291 PHE A O   1 
ATOM   1022 C CB  . PHE A 1 302 ? 168.228 158.625 179.518 1.00 59.68  ?  291 PHE A CB  1 
ATOM   1023 C CG  . PHE A 1 302 ? 166.767 158.662 179.835 1.00 59.68  ?  291 PHE A CG  1 
ATOM   1024 C CD1 . PHE A 1 302 ? 166.177 157.625 180.523 1.00 59.68  ?  291 PHE A CD1 1 
ATOM   1025 C CD2 . PHE A 1 302 ? 165.980 159.720 179.434 1.00 59.68  ?  291 PHE A CD2 1 
ATOM   1026 C CE1 . PHE A 1 302 ? 164.839 157.645 180.811 1.00 59.68  ?  291 PHE A CE1 1 
ATOM   1027 C CE2 . PHE A 1 302 ? 164.638 159.738 179.721 1.00 59.68  ?  291 PHE A CE2 1 
ATOM   1028 C CZ  . PHE A 1 302 ? 164.071 158.702 180.413 1.00 59.68  ?  291 PHE A CZ  1 
ATOM   1029 N N   . ASP A 1 303 ? 168.677 159.097 176.451 1.00 61.66  ?  292 ASP A N   1 
ATOM   1030 C CA  . ASP A 1 303 ? 168.315 159.563 175.117 1.00 61.66  ?  292 ASP A CA  1 
ATOM   1031 C C   . ASP A 1 303 ? 168.447 158.477 174.059 1.00 61.66  ?  292 ASP A C   1 
ATOM   1032 O O   . ASP A 1 303 ? 167.581 158.368 173.175 1.00 61.66  ?  292 ASP A O   1 
ATOM   1033 C CB  . ASP A 1 303 ? 169.205 160.740 174.734 1.00 61.66  ?  292 ASP A CB  1 
ATOM   1034 C CG  . ASP A 1 303 ? 168.966 161.956 175.597 1.00 61.66  ?  292 ASP A CG  1 
ATOM   1035 O OD1 . ASP A 1 303 ? 167.816 162.175 176.024 1.00 61.66  ?  292 ASP A OD1 1 
ATOM   1036 O OD2 . ASP A 1 303 ? 169.936 162.694 175.857 1.00 61.66  -1 292 ASP A OD2 1 
ATOM   1037 N N   . SER A 1 304 ? 169.506 157.670 174.157 1.00 59.96  ?  293 SER A N   1 
ATOM   1038 C CA  . SER A 1 304 ? 169.686 156.522 173.278 1.00 59.96  ?  293 SER A CA  1 
ATOM   1039 C C   . SER A 1 304 ? 168.560 155.515 173.454 1.00 59.96  ?  293 SER A C   1 
ATOM   1040 O O   . SER A 1 304 ? 168.058 154.955 172.476 1.00 59.96  ?  293 SER A O   1 
ATOM   1041 C CB  . SER A 1 304 ? 171.034 155.867 173.566 1.00 59.96  ?  293 SER A CB  1 
ATOM   1042 O OG  . SER A 1 304 ? 172.070 156.830 173.570 1.00 59.96  ?  293 SER A OG  1 
ATOM   1043 N N   . LEU A 1 305 ? 168.139 155.295 174.704 1.00 55.91  ?  294 LEU A N   1 
ATOM   1044 C CA  . LEU A 1 305 ? 167.030 154.397 174.999 1.00 55.91  ?  294 LEU A CA  1 
ATOM   1045 C C   . LEU A 1 305 ? 165.717 154.922 174.446 1.00 55.91  ?  294 LEU A C   1 
ATOM   1046 O O   . LEU A 1 305 ? 164.914 154.146 173.922 1.00 55.91  ?  294 LEU A O   1 
ATOM   1047 C CB  . LEU A 1 305 ? 166.923 154.196 176.505 1.00 55.91  ?  294 LEU A CB  1 
ATOM   1048 C CG  . LEU A 1 305 ? 165.759 153.359 177.024 1.00 55.91  ?  294 LEU A CG  1 
ATOM   1049 C CD1 . LEU A 1 305 ? 165.782 151.962 176.456 1.00 55.91  ?  294 LEU A CD1 1 
ATOM   1050 C CD2 . LEU A 1 305 ? 165.816 153.330 178.528 1.00 55.91  ?  294 LEU A CD2 1 
ATOM   1051 N N   . LEU A 1 306 ? 165.489 156.231 174.556 1.00 49.91  ?  295 LEU A N   1 
ATOM   1052 C CA  . LEU A 1 306 ? 164.253 156.831 174.058 1.00 49.91  ?  295 LEU A CA  1 
ATOM   1053 C C   . LEU A 1 306 ? 164.143 156.689 172.550 1.00 49.91  ?  295 LEU A C   1 
ATOM   1054 O O   . LEU A 1 306 ? 163.092 156.303 172.025 1.00 49.91  ?  295 LEU A O   1 
ATOM   1055 C CB  . LEU A 1 306 ? 164.193 158.299 174.455 1.00 49.91  ?  295 LEU A CB  1 
ATOM   1056 C CG  . LEU A 1 306 ? 163.824 158.633 175.890 1.00 49.91  ?  295 LEU A CG  1 
ATOM   1057 C CD1 . LEU A 1 306 ? 164.126 160.083 176.142 1.00 49.91  ?  295 LEU A CD1 1 
ATOM   1058 C CD2 . LEU A 1 306 ? 162.370 158.376 176.098 1.00 49.91  ?  295 LEU A CD2 1 
ATOM   1059 N N   . GLN A 1 307 ? 165.245 156.940 171.839 1.00 53.84  ?  296 GLN A N   1 
ATOM   1060 C CA  . GLN A 1 307 ? 165.225 156.791 170.385 1.00 53.84  ?  296 GLN A CA  1 
ATOM   1061 C C   . GLN A 1 307 ? 165.135 155.328 169.963 1.00 53.84  ?  296 GLN A C   1 
ATOM   1062 O O   . GLN A 1 307 ? 164.405 154.989 169.017 1.00 53.84  ?  296 GLN A O   1 
ATOM   1063 C CB  . GLN A 1 307 ? 166.456 157.453 169.781 1.00 53.84  ?  296 GLN A CB  1 
ATOM   1064 C CG  . GLN A 1 307 ? 166.532 158.922 170.081 1.00 53.84  ?  296 GLN A CG  1 
ATOM   1065 C CD  . GLN A 1 307 ? 165.502 159.705 169.309 1.00 53.84  ?  296 GLN A CD  1 
ATOM   1066 O OE1 . GLN A 1 307 ? 164.778 160.523 169.875 1.00 53.84  ?  296 GLN A OE1 1 
ATOM   1067 N NE2 . GLN A 1 307 ? 165.416 159.450 168.009 1.00 53.84  ?  296 GLN A NE2 1 
ATOM   1068 N N   . SER A 1 308 ? 165.840 154.448 170.679 1.00 49.58  ?  297 SER A N   1 
ATOM   1069 C CA  . SER A 1 308 ? 165.834 153.029 170.360 1.00 49.58  ?  297 SER A CA  1 
ATOM   1070 C C   . SER A 1 308 ? 164.472 152.401 170.607 1.00 49.58  ?  297 SER A C   1 
ATOM   1071 O O   . SER A 1 308 ? 164.080 151.462 169.906 1.00 49.58  ?  297 SER A O   1 
ATOM   1072 C CB  . SER A 1 308 ? 166.901 152.324 171.186 1.00 49.58  ?  297 SER A CB  1 
ATOM   1073 O OG  . SER A 1 308 ? 166.894 150.934 170.944 1.00 49.58  ?  297 SER A OG  1 
ATOM   1074 N N   . ALA A 1 309 ? 163.734 152.907 171.598 1.00 46.55  ?  298 ALA A N   1 
ATOM   1075 C CA  . ALA A 1 309 ? 162.376 152.431 171.824 1.00 46.55  ?  298 ALA A CA  1 
ATOM   1076 C C   . ALA A 1 309 ? 161.399 153.054 170.844 1.00 46.55  ?  298 ALA A C   1 
ATOM   1077 O O   . ALA A 1 309 ? 160.422 152.407 170.455 1.00 46.55  ?  298 ALA A O   1 
ATOM   1078 C CB  . ALA A 1 309 ? 161.949 152.720 173.257 1.00 46.55  ?  298 ALA A CB  1 
ATOM   1079 N N   . LYS A 1 310 ? 161.659 154.293 170.421 1.00 49.88  ?  299 LYS A N   1 
ATOM   1080 C CA  . LYS A 1 310 ? 160.795 154.944 169.446 1.00 49.88  ?  299 LYS A CA  1 
ATOM   1081 C C   . LYS A 1 310 ? 160.873 154.258 168.090 1.00 49.88  ?  299 LYS A C   1 
ATOM   1082 O O   . LYS A 1 310 ? 159.905 154.282 167.320 1.00 49.88  ?  299 LYS A O   1 
ATOM   1083 C CB  . LYS A 1 310 ? 161.174 156.417 169.343 1.00 49.88  ?  299 LYS A CB  1 
ATOM   1084 C CG  . LYS A 1 310 ? 160.281 157.271 168.490 1.00 49.88  ?  299 LYS A CG  1 
ATOM   1085 C CD  . LYS A 1 310 ? 160.734 158.716 168.552 1.00 49.88  ?  299 LYS A CD  1 
ATOM   1086 C CE  . LYS A 1 310 ? 160.401 159.318 169.906 1.00 49.88  ?  299 LYS A CE  1 
ATOM   1087 N NZ  . LYS A 1 310 ? 160.611 160.786 169.944 1.00 49.88  1  299 LYS A NZ  1 
ATOM   1088 N N   . LYS A 1 311 ? 162.002 153.608 167.788 1.00 50.72  ?  300 LYS A N   1 
ATOM   1089 C CA  . LYS A 1 311 ? 162.080 152.878 166.524 1.00 50.72  ?  300 LYS A CA  1 
ATOM   1090 C C   . LYS A 1 311 ? 161.183 151.643 166.512 1.00 50.72  ?  300 LYS A C   1 
ATOM   1091 O O   . LYS A 1 311 ? 160.574 151.338 165.481 1.00 50.72  ?  300 LYS A O   1 
ATOM   1092 C CB  . LYS A 1 311 ? 163.523 152.497 166.225 1.00 50.72  ?  300 LYS A CB  1 
ATOM   1093 C CG  . LYS A 1 311 ? 164.408 153.698 166.015 1.00 50.72  ?  300 LYS A CG  1 
ATOM   1094 C CD  . LYS A 1 311 ? 165.811 153.309 165.590 1.00 50.72  ?  300 LYS A CD  1 
ATOM   1095 C CE  . LYS A 1 311 ? 166.734 154.517 165.618 1.00 50.72  ?  300 LYS A CE  1 
ATOM   1096 N NZ  . LYS A 1 311 ? 166.311 155.561 164.651 1.00 50.72  1  300 LYS A NZ  1 
ATOM   1097 N N   . LYS A 1 312 ? 161.053 150.949 167.643 1.00 43.90  ?  301 LYS A N   1 
ATOM   1098 C CA  . LYS A 1 312 ? 160.261 149.727 167.726 1.00 43.90  ?  301 LYS A CA  1 
ATOM   1099 C C   . LYS A 1 312 ? 158.807 149.973 168.105 1.00 43.90  ?  301 LYS A C   1 
ATOM   1100 O O   . LYS A 1 312 ? 158.104 149.008 168.420 1.00 43.90  ?  301 LYS A O   1 
ATOM   1101 C CB  . LYS A 1 312 ? 160.884 148.769 168.735 1.00 43.90  ?  301 LYS A CB  1 
ATOM   1102 C CG  . LYS A 1 312 ? 162.328 148.491 168.486 1.00 43.90  ?  301 LYS A CG  1 
ATOM   1103 C CD  . LYS A 1 312 ? 162.757 147.191 169.128 1.00 43.90  ?  301 LYS A CD  1 
ATOM   1104 C CE  . LYS A 1 312 ? 164.212 146.885 168.800 1.00 43.90  ?  301 LYS A CE  1 
ATOM   1105 N NZ  . LYS A 1 312 ? 165.122 148.031 169.084 1.00 43.90  1  301 LYS A NZ  1 
ATOM   1106 N N   . SER A 1 313 ? 158.367 151.237 168.100 1.00 38.85  ?  302 SER A N   1 
ATOM   1107 C CA  . SER A 1 313 ? 156.995 151.677 168.394 1.00 38.85  ?  302 SER A CA  1 
ATOM   1108 C C   . SER A 1 313 ? 156.587 151.387 169.843 1.00 38.85  ?  302 SER A C   1 
ATOM   1109 O O   . SER A 1 313 ? 155.469 150.957 170.118 1.00 38.85  ?  302 SER A O   1 
ATOM   1110 C CB  . SER A 1 313 ? 155.984 151.092 167.399 1.00 38.85  ?  302 SER A CB  1 
ATOM   1111 O OG  . SER A 1 313 ? 154.679 151.094 167.929 1.00 38.85  ?  302 SER A OG  1 
ATOM   1112 N N   . ILE A 1 314 ? 157.481 151.682 170.779 1.00 31.07  ?  303 ILE A N   1 
ATOM   1113 C CA  . ILE A 1 314 ? 157.218 151.530 172.201 1.00 31.07  ?  303 ILE A CA  1 
ATOM   1114 C C   . ILE A 1 314 ? 157.403 152.886 172.862 1.00 31.07  ?  303 ILE A C   1 
ATOM   1115 O O   . ILE A 1 314 ? 158.454 153.510 172.715 1.00 31.07  ?  303 ILE A O   1 
ATOM   1116 C CB  . ILE A 1 314 ? 158.139 150.482 172.840 1.00 31.07  ?  303 ILE A CB  1 
ATOM   1117 C CG1 . ILE A 1 314 ? 157.818 149.097 172.296 1.00 31.07  ?  303 ILE A CG1 1 
ATOM   1118 C CG2 . ILE A 1 314 ? 157.980 150.465 174.328 1.00 31.07  ?  303 ILE A CG2 1 
ATOM   1119 C CD1 . ILE A 1 314 ? 158.804 148.046 172.739 1.00 31.07  ?  303 ILE A CD1 1 
ATOM   1120 N N   . ARG A 1 315 ? 156.392 153.340 173.587 1.00 19.11  ?  304 ARG A N   1 
ATOM   1121 C CA  . ARG A 1 315 ? 156.472 154.605 174.298 1.00 19.11  ?  304 ARG A CA  1 
ATOM   1122 C C   . ARG A 1 315 ? 157.021 154.406 175.698 1.00 19.11  ?  304 ARG A C   1 
ATOM   1123 O O   . ARG A 1 315 ? 156.914 153.325 176.265 1.00 19.11  ?  304 ARG A O   1 
ATOM   1124 C CB  . ARG A 1 315 ? 155.105 155.263 174.372 1.00 19.11  ?  304 ARG A CB  1 
ATOM   1125 C CG  . ARG A 1 315 ? 154.862 156.241 173.275 1.00 19.11  ?  304 ARG A CG  1 
ATOM   1126 C CD  . ARG A 1 315 ? 154.359 155.578 172.054 1.00 19.11  ?  304 ARG A CD  1 
ATOM   1127 N NE  . ARG A 1 315 ? 154.141 156.572 171.030 1.00 19.11  ?  304 ARG A NE  1 
ATOM   1128 C CZ  . ARG A 1 315 ? 153.398 156.370 169.956 1.00 19.11  ?  304 ARG A CZ  1 
ATOM   1129 N NH1 . ARG A 1 315 ? 152.815 155.199 169.765 1.00 19.11  1  304 ARG A NH1 1 
ATOM   1130 N NH2 . ARG A 1 315 ? 153.247 157.341 169.075 1.00 19.11  ?  304 ARG A NH2 1 
ATOM   1131 N N   . VAL A 1 316 ? 157.612 155.454 176.253 1.00 17.44  ?  305 VAL A N   1 
ATOM   1132 C CA  . VAL A 1 316 ? 158.282 155.373 177.541 1.00 17.44  ?  305 VAL A CA  1 
ATOM   1133 C C   . VAL A 1 316 ? 157.627 156.347 178.507 1.00 17.44  ?  305 VAL A C   1 
ATOM   1134 O O   . VAL A 1 316 ? 157.615 157.556 178.268 1.00 17.44  ?  305 VAL A O   1 
ATOM   1135 C CB  . VAL A 1 316 ? 159.784 155.645 177.414 1.00 17.44  ?  305 VAL A CB  1 
ATOM   1136 C CG1 . VAL A 1 316 ? 160.418 155.754 178.772 1.00 17.44  ?  305 VAL A CG1 1 
ATOM   1137 C CG2 . VAL A 1 316 ? 160.434 154.536 176.642 1.00 17.44  ?  305 VAL A CG2 1 
ATOM   1138 N N   . ILE A 1 317 ? 157.110 155.818 179.608 1.00 18.09  ?  306 ILE A N   1 
ATOM   1139 C CA  . ILE A 1 317 ? 156.511 156.593 180.685 1.00 18.09  ?  306 ILE A CA  1 
ATOM   1140 C C   . ILE A 1 317 ? 157.475 156.585 181.860 1.00 18.09  ?  306 ILE A C   1 
ATOM   1141 O O   . ILE A 1 317 ? 158.052 155.546 182.184 1.00 18.09  ?  306 ILE A O   1 
ATOM   1142 C CB  . ILE A 1 317 ? 155.139 155.999 181.045 1.00 18.09  ?  306 ILE A CB  1 
ATOM   1143 C CG1 . ILE A 1 317 ? 154.172 156.262 179.912 1.00 18.09  ?  306 ILE A CG1 1 
ATOM   1144 C CG2 . ILE A 1 317 ? 154.605 156.525 182.323 1.00 18.09  ?  306 ILE A CG2 1 
ATOM   1145 C CD1 . ILE A 1 317 ? 153.143 155.217 179.798 1.00 18.09  ?  306 ILE A CD1 1 
ATOM   1146 N N   . LEU A 1 318 ? 157.682 157.742 182.471 1.00 22.46  ?  307 LEU A N   1 
ATOM   1147 C CA  . LEU A 1 318 ? 158.655 157.899 183.537 1.00 22.46  ?  307 LEU A CA  1 
ATOM   1148 C C   . LEU A 1 318 ? 157.942 158.058 184.869 1.00 22.46  ?  307 LEU A C   1 
ATOM   1149 O O   . LEU A 1 318 ? 157.071 158.909 185.000 1.00 22.46  ?  307 LEU A O   1 
ATOM   1150 C CB  . LEU A 1 318 ? 159.540 159.111 183.267 1.00 22.46  ?  307 LEU A CB  1 
ATOM   1151 C CG  . LEU A 1 318 ? 160.603 159.526 184.283 1.00 22.46  ?  307 LEU A CG  1 
ATOM   1152 C CD1 . LEU A 1 318 ? 161.692 158.503 184.337 1.00 22.46  ?  307 LEU A CD1 1 
ATOM   1153 C CD2 . LEU A 1 318 ? 161.170 160.847 183.919 1.00 22.46  ?  307 LEU A CD2 1 
ATOM   1154 N N   . ASP A 1 319 ? 158.321 157.253 185.857 1.00 23.74  ?  308 ASP A N   1 
ATOM   1155 C CA  . ASP A 1 319 ? 157.765 157.376 187.198 1.00 23.74  ?  308 ASP A CA  1 
ATOM   1156 C C   . ASP A 1 319 ? 158.478 158.490 187.945 1.00 23.74  ?  308 ASP A C   1 
ATOM   1157 O O   . ASP A 1 319 ? 159.706 158.509 188.015 1.00 23.74  ?  308 ASP A O   1 
ATOM   1158 C CB  . ASP A 1 319 ? 157.905 156.060 187.952 1.00 23.74  ?  308 ASP A CB  1 
ATOM   1159 C CG  . ASP A 1 319 ? 156.923 155.915 189.087 1.00 23.74  ?  308 ASP A CG  1 
ATOM   1160 O OD1 . ASP A 1 319 ? 156.543 156.905 189.719 1.00 23.74  ?  308 ASP A OD1 1 
ATOM   1161 O OD2 . ASP A 1 319 ? 156.528 154.781 189.366 1.00 23.74  -1 308 ASP A OD2 1 
ATOM   1162 N N   . LEU A 1 320 ? 157.709 159.411 188.515 1.00 31.39  ?  309 LEU A N   1 
ATOM   1163 C CA  . LEU A 1 320 ? 158.252 160.602 189.152 1.00 31.39  ?  309 LEU A CA  1 
ATOM   1164 C C   . LEU A 1 320 ? 157.850 160.709 190.614 1.00 31.39  ?  309 LEU A C   1 
ATOM   1165 O O   . LEU A 1 320 ? 157.647 161.808 191.122 1.00 31.39  ?  309 LEU A O   1 
ATOM   1166 C CB  . LEU A 1 320 ? 157.803 161.854 188.413 1.00 31.39  ?  309 LEU A CB  1 
ATOM   1167 C CG  . LEU A 1 320 ? 158.588 162.291 187.195 1.00 31.39  ?  309 LEU A CG  1 
ATOM   1168 C CD1 . LEU A 1 320 ? 158.044 163.622 186.803 1.00 31.39  ?  309 LEU A CD1 1 
ATOM   1169 C CD2 . LEU A 1 320 ? 160.050 162.394 187.535 1.00 31.39  ?  309 LEU A CD2 1 
ATOM   1170 N N   . THR A 1 321 ? 157.716 159.588 191.289 1.00 31.52  ?  310 THR A N   1 
ATOM   1171 C CA  . THR A 1 321 ? 157.406 159.591 192.709 1.00 31.52  ?  310 THR A CA  1 
ATOM   1172 C C   . THR A 1 321 ? 158.621 160.082 193.486 1.00 31.52  ?  310 THR A C   1 
ATOM   1173 O O   . THR A 1 321 ? 159.715 159.556 193.285 1.00 31.52  ?  310 THR A O   1 
ATOM   1174 C CB  . THR A 1 321 ? 157.039 158.196 193.147 1.00 31.52  ?  310 THR A CB  1 
ATOM   1175 O OG1 . THR A 1 321 ? 156.119 157.645 192.207 1.00 31.52  ?  310 THR A OG1 1 
ATOM   1176 C CG2 . THR A 1 321 ? 156.388 158.240 194.459 1.00 31.52  ?  310 THR A CG2 1 
ATOM   1177 N N   . PRO A 1 322 ? 158.490 161.107 194.332 1.00 39.36  ?  311 PRO A N   1 
ATOM   1178 C CA  . PRO A 1 322 ? 159.680 161.740 194.922 1.00 39.36  ?  311 PRO A CA  1 
ATOM   1179 C C   . PRO A 1 322 ? 160.463 160.876 195.891 1.00 39.36  ?  311 PRO A C   1 
ATOM   1180 O O   . PRO A 1 322 ? 161.658 160.664 195.698 1.00 39.36  ?  311 PRO A O   1 
ATOM   1181 C CB  . PRO A 1 322 ? 159.103 162.966 195.635 1.00 39.36  ?  311 PRO A CB  1 
ATOM   1182 C CG  . PRO A 1 322 ? 157.802 163.202 194.996 1.00 39.36  ?  311 PRO A CG  1 
ATOM   1183 C CD  . PRO A 1 322 ? 157.270 161.866 194.633 1.00 39.36  ?  311 PRO A CD  1 
ATOM   1184 N N   . ASN A 1 323 ? 159.805 160.354 196.924 1.00 47.30  ?  312 ASN A N   1 
ATOM   1185 C CA  . ASN A 1 323 ? 160.485 159.589 197.961 1.00 47.30  ?  312 ASN A CA  1 
ATOM   1186 C C   . ASN A 1 323 ? 160.279 158.101 197.721 1.00 47.30  ?  312 ASN A C   1 
ATOM   1187 O O   . ASN A 1 323 ? 159.555 157.422 198.440 1.00 47.30  ?  312 ASN A O   1 
ATOM   1188 C CB  . ASN A 1 323 ? 159.983 159.989 199.333 1.00 47.30  ?  312 ASN A CB  1 
ATOM   1189 C CG  . ASN A 1 323 ? 160.855 159.459 200.440 1.00 47.30  ?  312 ASN A CG  1 
ATOM   1190 O OD1 . ASN A 1 323 ? 162.078 159.463 200.333 1.00 47.30  ?  312 ASN A OD1 1 
ATOM   1191 N ND2 . ASN A 1 323 ? 160.232 158.986 201.506 1.00 47.30  ?  312 ASN A ND2 1 
ATOM   1192 N N   . TYR A 1 324 ? 160.958 157.579 196.712 1.00 40.57  ?  313 TYR A N   1 
ATOM   1193 C CA  . TYR A 1 324 ? 160.787 156.185 196.350 1.00 40.57  ?  313 TYR A CA  1 
ATOM   1194 C C   . TYR A 1 324 ? 161.791 155.276 197.030 1.00 40.57  ?  313 TYR A C   1 
ATOM   1195 O O   . TYR A 1 324 ? 161.823 154.080 196.741 1.00 40.57  ?  313 TYR A O   1 
ATOM   1196 C CB  . TYR A 1 324 ? 160.860 156.019 194.840 1.00 40.57  ?  313 TYR A CB  1 
ATOM   1197 C CG  . TYR A 1 324 ? 162.224 156.152 194.238 1.00 40.57  ?  313 TYR A CG  1 
ATOM   1198 C CD1 . TYR A 1 324 ? 162.793 157.390 194.042 1.00 40.57  ?  313 TYR A CD1 1 
ATOM   1199 C CD2 . TYR A 1 324 ? 162.921 155.038 193.813 1.00 40.57  ?  313 TYR A CD2 1 
ATOM   1200 C CE1 . TYR A 1 324 ? 164.018 157.513 193.470 1.00 40.57  ?  313 TYR A CE1 1 
ATOM   1201 C CE2 . TYR A 1 324 ? 164.146 155.158 193.243 1.00 40.57  ?  313 TYR A CE2 1 
ATOM   1202 C CZ  . TYR A 1 324 ? 164.689 156.399 193.077 1.00 40.57  ?  313 TYR A CZ  1 
ATOM   1203 O OH  . TYR A 1 324 ? 165.921 156.534 192.503 1.00 40.57  ?  313 TYR A OH  1 
ATOM   1204 N N   . ARG A 1 325 ? 162.606 155.819 197.925 1.00 48.59  ?  314 ARG A N   1 
ATOM   1205 C CA  . ARG A 1 325 ? 163.430 155.052 198.853 1.00 48.59  ?  314 ARG A CA  1 
ATOM   1206 C C   . ARG A 1 325 ? 162.993 155.540 200.227 1.00 48.59  ?  314 ARG A C   1 
ATOM   1207 O O   . ARG A 1 325 ? 163.437 156.591 200.687 1.00 48.59  ?  314 ARG A O   1 
ATOM   1208 C CB  . ARG A 1 325 ? 164.907 155.270 198.610 1.00 48.59  ?  314 ARG A CB  1 
ATOM   1209 C CG  . ARG A 1 325 ? 165.334 155.217 197.160 1.00 48.59  ?  314 ARG A CG  1 
ATOM   1210 C CD  . ARG A 1 325 ? 166.840 155.421 197.051 1.00 48.59  ?  314 ARG A CD  1 
ATOM   1211 N NE  . ARG A 1 325 ? 167.329 155.510 195.681 1.00 48.59  ?  314 ARG A NE  1 
ATOM   1212 C CZ  . ARG A 1 325 ? 167.605 154.457 194.925 1.00 48.59  ?  314 ARG A CZ  1 
ATOM   1213 N NH1 . ARG A 1 325 ? 167.422 153.236 195.396 1.00 48.59  1  314 ARG A NH1 1 
ATOM   1214 N NH2 . ARG A 1 325 ? 168.054 154.618 193.693 1.00 48.59  ?  314 ARG A NH2 1 
ATOM   1215 N N   . GLY A 1 326 ? 162.075 154.823 200.853 1.00 48.72  ?  315 GLY A N   1 
ATOM   1216 C CA  . GLY A 1 326 ? 161.533 155.282 202.113 1.00 48.72  ?  315 GLY A CA  1 
ATOM   1217 C C   . GLY A 1 326 ? 160.136 154.756 202.303 1.00 48.72  ?  315 GLY A C   1 
ATOM   1218 O O   . GLY A 1 326 ? 159.464 154.344 201.359 1.00 48.72  ?  315 GLY A O   1 
ATOM   1219 N N   . GLU A 1 327 ? 159.700 154.790 203.561 1.00 57.16  ?  316 GLU A N   1 
ATOM   1220 C CA  . GLU A 1 327 ? 158.419 154.191 203.915 1.00 57.16  ?  316 GLU A CA  1 
ATOM   1221 C C   . GLU A 1 327 ? 157.267 155.098 203.512 1.00 57.16  ?  316 GLU A C   1 
ATOM   1222 O O   . GLU A 1 327 ? 156.233 154.627 203.029 1.00 57.16  ?  316 GLU A O   1 
ATOM   1223 C CB  . GLU A 1 327 ? 158.387 153.877 205.416 1.00 57.16  ?  316 GLU A CB  1 
ATOM   1224 C CG  . GLU A 1 327 ? 157.061 153.304 205.957 1.00 57.16  ?  316 GLU A CG  1 
ATOM   1225 C CD  . GLU A 1 327 ? 156.092 154.364 206.481 1.00 57.16  ?  316 GLU A CD  1 
ATOM   1226 O OE1 . GLU A 1 327 ? 156.537 155.482 206.807 1.00 57.16  ?  316 GLU A OE1 1 
ATOM   1227 O OE2 . GLU A 1 327 ? 154.884 154.073 206.561 1.00 57.16  -1 316 GLU A OE2 1 
ATOM   1228 N N   . ASN A 1 328 ? 157.418 156.399 203.717 1.00 52.01  ?  317 ASN A N   1 
ATOM   1229 C CA  . ASN A 1 328 ? 156.387 157.338 203.322 1.00 52.01  ?  317 ASN A CA  1 
ATOM   1230 C C   . ASN A 1 328 ? 156.841 158.052 202.064 1.00 52.01  ?  317 ASN A C   1 
ATOM   1231 O O   . ASN A 1 328 ? 157.899 158.682 202.029 1.00 52.01  ?  317 ASN A O   1 
ATOM   1232 C CB  . ASN A 1 328 ? 156.082 158.325 204.443 1.00 52.01  ?  317 ASN A CB  1 
ATOM   1233 C CG  . ASN A 1 328 ? 154.748 159.003 204.271 1.00 52.01  ?  317 ASN A CG  1 
ATOM   1234 O OD1 . ASN A 1 328 ? 154.115 158.905 203.226 1.00 52.01  ?  317 ASN A OD1 1 
ATOM   1235 N ND2 . ASN A 1 328 ? 154.272 159.625 205.331 1.00 52.01  ?  317 ASN A ND2 1 
ATOM   1236 N N   . SER A 1 329 ? 156.013 157.951 201.037 1.00 46.07  ?  318 SER A N   1 
ATOM   1237 C CA  . SER A 1 329 ? 156.422 158.072 199.654 1.00 46.07  ?  318 SER A CA  1 
ATOM   1238 C C   . SER A 1 329 ? 156.384 159.495 199.128 1.00 46.07  ?  318 SER A C   1 
ATOM   1239 O O   . SER A 1 329 ? 156.855 159.739 198.016 1.00 46.07  ?  318 SER A O   1 
ATOM   1240 C CB  . SER A 1 329 ? 155.529 157.172 198.810 1.00 46.07  ?  318 SER A CB  1 
ATOM   1241 O OG  . SER A 1 329 ? 155.503 157.604 197.482 1.00 46.07  ?  318 SER A OG  1 
ATOM   1242 N N   . TRP A 1 330 ? 155.857 160.442 199.904 1.00 42.04  ?  319 TRP A N   1 
ATOM   1243 C CA  . TRP A 1 330 ? 155.665 161.802 199.423 1.00 42.04  ?  319 TRP A CA  1 
ATOM   1244 C C   . TRP A 1 330 ? 156.192 162.849 200.391 1.00 42.04  ?  319 TRP A C   1 
ATOM   1245 O O   . TRP A 1 330 ? 155.666 163.967 200.391 1.00 42.04  ?  319 TRP A O   1 
ATOM   1246 C CB  . TRP A 1 330 ? 154.190 162.084 199.151 1.00 42.04  ?  319 TRP A CB  1 
ATOM   1247 C CG  . TRP A 1 330 ? 153.717 161.648 197.834 1.00 42.04  ?  319 TRP A CG  1 
ATOM   1248 C CD1 . TRP A 1 330 ? 153.099 160.497 197.553 1.00 42.04  ?  319 TRP A CD1 1 
ATOM   1249 C CD2 . TRP A 1 330 ? 153.821 162.363 196.608 1.00 42.04  ?  319 TRP A CD2 1 
ATOM   1250 N NE1 . TRP A 1 330 ? 152.801 160.427 196.224 1.00 42.04  ?  319 TRP A NE1 1 
ATOM   1251 C CE2 . TRP A 1 330 ? 153.242 161.567 195.616 1.00 42.04  ?  319 TRP A CE2 1 
ATOM   1252 C CE3 . TRP A 1 330 ? 154.357 163.596 196.250 1.00 42.04  ?  319 TRP A CE3 1 
ATOM   1253 C CZ2 . TRP A 1 330 ? 153.173 161.958 194.293 1.00 42.04  ?  319 TRP A CZ2 1 
ATOM   1254 C CZ3 . TRP A 1 330 ? 154.285 163.988 194.939 1.00 42.04  ?  319 TRP A CZ3 1 
ATOM   1255 C CH2 . TRP A 1 330 ? 153.701 163.172 193.974 1.00 42.04  ?  319 TRP A CH2 1 
ATOM   1256 N N   . PHE A 1 331 ? 157.200 162.509 201.208 1.00 58.80  ?  320 PHE A N   1 
ATOM   1257 C CA  . PHE A 1 331 ? 157.931 163.448 202.067 1.00 58.80  ?  320 PHE A CA  1 
ATOM   1258 C C   . PHE A 1 331 ? 156.994 164.144 203.061 1.00 58.80  ?  320 PHE A C   1 
ATOM   1259 O O   . PHE A 1 331 ? 156.635 165.311 202.901 1.00 58.80  ?  320 PHE A O   1 
ATOM   1260 C CB  . PHE A 1 331 ? 158.699 164.481 201.234 1.00 58.80  ?  320 PHE A CB  1 
ATOM   1261 C CG  . PHE A 1 331 ? 159.966 163.970 200.641 1.00 58.80  ?  320 PHE A CG  1 
ATOM   1262 C CD1 . PHE A 1 331 ? 160.791 163.129 201.355 1.00 58.80  ?  320 PHE A CD1 1 
ATOM   1263 C CD2 . PHE A 1 331 ? 160.336 164.340 199.364 1.00 58.80  ?  320 PHE A CD2 1 
ATOM   1264 C CE1 . PHE A 1 331 ? 161.960 162.669 200.800 1.00 58.80  ?  320 PHE A CE1 1 
ATOM   1265 C CE2 . PHE A 1 331 ? 161.500 163.883 198.812 1.00 58.80  ?  320 PHE A CE2 1 
ATOM   1266 C CZ  . PHE A 1 331 ? 162.308 163.044 199.530 1.00 58.80  ?  320 PHE A CZ  1 
ATOM   1267 N N   . SER A 1 332 ? 156.570 163.379 204.072 1.00 69.68  ?  321 SER A N   1 
ATOM   1268 C CA  . SER A 1 332 ? 155.487 163.743 204.990 1.00 69.68  ?  321 SER A CA  1 
ATOM   1269 C C   . SER A 1 332 ? 155.554 165.092 205.719 1.00 69.68  ?  321 SER A C   1 
ATOM   1270 O O   . SER A 1 332 ? 154.574 165.483 206.358 1.00 69.68  ?  321 SER A O   1 
ATOM   1271 C CB  . SER A 1 332 ? 155.365 162.665 206.064 1.00 69.68  ?  321 SER A CB  1 
ATOM   1272 O OG  . SER A 1 332 ? 156.499 162.652 206.914 1.00 69.68  ?  321 SER A OG  1 
ATOM   1273 N N   . THR A 1 333 ? 156.672 165.815 205.654 1.00 76.64  ?  322 THR A N   1 
ATOM   1274 C CA  . THR A 1 333 ? 156.783 167.055 206.415 1.00 76.64  ?  322 THR A CA  1 
ATOM   1275 C C   . THR A 1 333 ? 156.279 168.269 205.639 1.00 76.64  ?  322 THR A C   1 
ATOM   1276 O O   . THR A 1 333 ? 155.481 169.054 206.160 1.00 76.64  ?  322 THR A O   1 
ATOM   1277 C CB  . THR A 1 333 ? 158.232 167.283 206.859 1.00 76.64  ?  322 THR A CB  1 
ATOM   1278 O OG1 . THR A 1 333 ? 158.676 166.165 207.636 1.00 76.64  ?  322 THR A OG1 1 
ATOM   1279 C CG2 . THR A 1 333 ? 158.339 168.538 207.708 1.00 76.64  ?  322 THR A CG2 1 
ATOM   1280 N N   . GLN A 1 334 ? 156.727 168.438 204.401 1.00 79.39  ?  323 GLN A N   1 
ATOM   1281 C CA  . GLN A 1 334 ? 156.338 169.589 203.598 1.00 79.39  ?  323 GLN A CA  1 
ATOM   1282 C C   . GLN A 1 334 ? 155.422 169.099 202.488 1.00 79.39  ?  323 GLN A C   1 
ATOM   1283 O O   . GLN A 1 334 ? 155.448 167.927 202.106 1.00 79.39  ?  323 GLN A O   1 
ATOM   1284 C CB  . GLN A 1 334 ? 157.569 170.311 203.032 1.00 79.39  ?  323 GLN A CB  1 
ATOM   1285 C CG  . GLN A 1 334 ? 158.498 170.920 204.068 1.00 79.39  ?  323 GLN A CG  1 
ATOM   1286 C CD  . GLN A 1 334 ? 159.639 169.998 204.433 1.00 79.39  ?  323 GLN A CD  1 
ATOM   1287 O OE1 . GLN A 1 334 ? 159.820 168.948 203.820 1.00 79.39  ?  323 GLN A OE1 1 
ATOM   1288 N NE2 . GLN A 1 334 ? 160.421 170.387 205.433 1.00 79.39  ?  323 GLN A NE2 1 
ATOM   1289 N N   . VAL A 1 335 ? 154.593 169.995 201.957 1.00 77.19  ?  324 VAL A N   1 
ATOM   1290 C CA  . VAL A 1 335 ? 153.711 169.636 200.850 1.00 77.19  ?  324 VAL A CA  1 
ATOM   1291 C C   . VAL A 1 335 ? 153.891 170.549 199.647 1.00 77.19  ?  324 VAL A C   1 
ATOM   1292 O O   . VAL A 1 335 ? 153.699 170.108 198.499 1.00 77.19  ?  324 VAL A O   1 
ATOM   1293 C CB  . VAL A 1 335 ? 152.225 169.646 201.314 1.00 77.19  ?  324 VAL A CB  1 
ATOM   1294 C CG1 . VAL A 1 335 ? 151.281 169.063 200.264 1.00 77.19  ?  324 VAL A CG1 1 
ATOM   1295 C CG2 . VAL A 1 335 ? 152.013 168.933 202.658 1.00 77.19  ?  324 VAL A CG2 1 
ATOM   1296 N N   . ASP A 1 336 ? 154.393 171.769 199.812 1.00 79.09  ?  325 ASP A N   1 
ATOM   1297 C CA  . ASP A 1 336 ? 154.451 172.722 198.710 1.00 79.09  ?  325 ASP A CA  1 
ATOM   1298 C C   . ASP A 1 336 ? 155.700 172.571 197.856 1.00 79.09  ?  325 ASP A C   1 
ATOM   1299 O O   . ASP A 1 336 ? 155.621 172.667 196.620 1.00 79.09  ?  325 ASP A O   1 
ATOM   1300 C CB  . ASP A 1 336 ? 154.365 174.149 199.257 1.00 79.09  ?  325 ASP A CB  1 
ATOM   1301 C CG  . ASP A 1 336 ? 155.464 174.461 200.263 1.00 79.09  ?  325 ASP A CG  1 
ATOM   1302 O OD1 . ASP A 1 336 ? 155.302 174.118 201.456 1.00 79.09  ?  325 ASP A OD1 1 
ATOM   1303 O OD2 . ASP A 1 336 ? 156.501 175.024 199.851 1.00 79.09  -1 325 ASP A OD2 1 
ATOM   1304 N N   . THR A 1 337 ? 156.847 172.309 198.483 1.00 75.79  ?  326 THR A N   1 
ATOM   1305 C CA  . THR A 1 337 ? 158.095 172.292 197.737 1.00 75.79  ?  326 THR A CA  1 
ATOM   1306 C C   . THR A 1 337 ? 158.210 171.027 196.897 1.00 75.79  ?  326 THR A C   1 
ATOM   1307 O O   . THR A 1 337 ? 158.776 171.063 195.802 1.00 75.79  ?  326 THR A O   1 
ATOM   1308 C CB  . THR A 1 337 ? 159.281 172.463 198.694 1.00 75.79  ?  326 THR A CB  1 
ATOM   1309 O OG1 . THR A 1 337 ? 160.514 172.374 197.971 1.00 75.79  ?  326 THR A OG1 1 
ATOM   1310 C CG2 . THR A 1 337 ? 159.250 171.430 199.816 1.00 75.79  ?  326 THR A CG2 1 
ATOM   1311 N N   . VAL A 1 338 ? 157.610 169.920 197.345 1.00 72.15  ?  327 VAL A N   1 
ATOM   1312 C CA  . VAL A 1 338 ? 157.641 168.708 196.532 1.00 72.15  ?  327 VAL A CA  1 
ATOM   1313 C C   . VAL A 1 338 ? 156.693 168.832 195.341 1.00 72.15  ?  327 VAL A C   1 
ATOM   1314 O O   . VAL A 1 338 ? 156.981 168.316 194.252 1.00 72.15  ?  327 VAL A O   1 
ATOM   1315 C CB  . VAL A 1 338 ? 157.353 167.471 197.403 1.00 72.15  ?  327 VAL A CB  1 
ATOM   1316 C CG1 . VAL A 1 338 ? 158.406 167.352 198.478 1.00 72.15  ?  327 VAL A CG1 1 
ATOM   1317 C CG2 . VAL A 1 338 ? 155.991 167.545 198.046 1.00 72.15  ?  327 VAL A CG2 1 
ATOM   1318 N N   . ALA A 1 339 ? 155.593 169.567 195.494 1.00 66.98  ?  328 ALA A N   1 
ATOM   1319 C CA  . ALA A 1 339 ? 154.761 169.915 194.356 1.00 66.98  ?  328 ALA A CA  1 
ATOM   1320 C C   . ALA A 1 339 ? 155.471 170.831 193.376 1.00 66.98  ?  328 ALA A C   1 
ATOM   1321 O O   . ALA A 1 339 ? 155.218 170.733 192.172 1.00 66.98  ?  328 ALA A O   1 
ATOM   1322 C CB  . ALA A 1 339 ? 153.481 170.585 194.830 1.00 66.98  ?  328 ALA A CB  1 
ATOM   1323 N N   . THR A 1 340 ? 156.346 171.710 193.868 1.00 67.15  ?  329 THR A N   1 
ATOM   1324 C CA  . THR A 1 340 ? 157.185 172.519 192.990 1.00 67.15  ?  329 THR A CA  1 
ATOM   1325 C C   . THR A 1 340 ? 158.193 171.656 192.228 1.00 67.15  ?  329 THR A C   1 
ATOM   1326 O O   . THR A 1 340 ? 158.453 171.897 191.037 1.00 67.15  ?  329 THR A O   1 
ATOM   1327 C CB  . THR A 1 340 ? 157.892 173.590 193.826 1.00 67.15  ?  329 THR A CB  1 
ATOM   1328 O OG1 . THR A 1 340 ? 156.919 174.322 194.580 1.00 67.15  ?  329 THR A OG1 1 
ATOM   1329 C CG2 . THR A 1 340 ? 158.649 174.569 192.946 1.00 67.15  ?  329 THR A CG2 1 
ATOM   1330 N N   . LYS A 1 341 ? 158.750 170.640 192.910 1.00 65.12  ?  330 LYS A N   1 
ATOM   1331 C CA  . LYS A 1 341 ? 159.653 169.672 192.281 1.00 65.12  ?  330 LYS A CA  1 
ATOM   1332 C C   . LYS A 1 341 ? 158.991 168.953 191.120 1.00 65.12  ?  330 LYS A C   1 
ATOM   1333 O O   . LYS A 1 341 ? 159.571 168.875 190.029 1.00 65.12  ?  330 LYS A O   1 
ATOM   1334 C CB  . LYS A 1 341 ? 160.107 168.609 193.277 1.00 65.12  ?  330 LYS A CB  1 
ATOM   1335 C CG  . LYS A 1 341 ? 160.869 169.074 194.478 1.00 65.12  ?  330 LYS A CG  1 
ATOM   1336 C CD  . LYS A 1 341 ? 162.300 169.421 194.202 1.00 65.12  ?  330 LYS A CD  1 
ATOM   1337 C CE  . LYS A 1 341 ? 162.932 169.881 195.496 1.00 65.12  ?  330 LYS A CE  1 
ATOM   1338 N NZ  . LYS A 1 341 ? 162.919 168.783 196.511 1.00 65.12  1  330 LYS A NZ  1 
ATOM   1339 N N   . VAL A 1 342 ? 157.785 168.426 191.341 1.00 56.50  ?  331 VAL A N   1 
ATOM   1340 C CA  . VAL A 1 342 ? 157.103 167.669 190.295 1.00 56.50  ?  331 VAL A CA  1 
ATOM   1341 C C   . VAL A 1 342 ? 156.706 168.589 189.146 1.00 56.50  ?  331 VAL A C   1 
ATOM   1342 O O   . VAL A 1 342 ? 156.760 168.205 187.968 1.00 56.50  ?  331 VAL A O   1 
ATOM   1343 C CB  . VAL A 1 342 ? 155.896 166.922 190.887 1.00 56.50  ?  331 VAL A CB  1 
ATOM   1344 C CG1 . VAL A 1 342 ? 155.217 166.079 189.844 1.00 56.50  ?  331 VAL A CG1 1 
ATOM   1345 C CG2 . VAL A 1 342 ? 156.347 166.043 192.009 1.00 56.50  ?  331 VAL A CG2 1 
ATOM   1346 N N   . LYS A 1 343 ? 156.377 169.841 189.468 1.00 58.42  ?  332 LYS A N   1 
ATOM   1347 C CA  . LYS A 1 343 ? 155.973 170.803 188.452 1.00 58.42  ?  332 LYS A CA  1 
ATOM   1348 C C   . LYS A 1 343 ? 157.131 171.164 187.537 1.00 58.42  ?  332 LYS A C   1 
ATOM   1349 O O   . LYS A 1 343 ? 156.944 171.358 186.331 1.00 58.42  ?  332 LYS A O   1 
ATOM   1350 C CB  . LYS A 1 343 ? 155.427 172.046 189.130 1.00 58.42  ?  332 LYS A CB  1 
ATOM   1351 C CG  . LYS A 1 343 ? 154.788 173.036 188.197 1.00 58.42  ?  332 LYS A CG  1 
ATOM   1352 C CD  . LYS A 1 343 ? 154.316 174.234 188.974 1.00 58.42  ?  332 LYS A CD  1 
ATOM   1353 C CE  . LYS A 1 343 ? 153.242 173.815 189.953 1.00 58.42  ?  332 LYS A CE  1 
ATOM   1354 N NZ  . LYS A 1 343 ? 152.071 173.284 189.243 1.00 58.42  1  332 LYS A NZ  1 
ATOM   1355 N N   . ASP A 1 344 ? 158.339 171.242 188.085 1.00 59.20  ?  333 ASP A N   1 
ATOM   1356 C CA  . ASP A 1 344 ? 159.489 171.454 187.212 1.00 59.20  ?  333 ASP A CA  1 
ATOM   1357 C C   . ASP A 1 344 ? 159.875 170.193 186.448 1.00 59.20  ?  333 ASP A C   1 
ATOM   1358 O O   . ASP A 1 344 ? 160.304 170.281 185.287 1.00 59.20  ?  333 ASP A O   1 
ATOM   1359 C CB  . ASP A 1 344 ? 160.672 171.963 188.025 1.00 59.20  ?  333 ASP A CB  1 
ATOM   1360 C CG  . ASP A 1 344 ? 160.404 173.314 188.624 1.00 59.20  ?  333 ASP A CG  1 
ATOM   1361 O OD1 . ASP A 1 344 ? 159.539 174.028 188.084 1.00 59.20  ?  333 ASP A OD1 1 
ATOM   1362 O OD2 . ASP A 1 344 ? 161.065 173.674 189.614 1.00 59.20  -1 333 ASP A OD2 1 
ATOM   1363 N N   . ALA A 1 345 ? 159.723 169.026 187.079 1.00 52.05  ?  334 ALA A N   1 
ATOM   1364 C CA  . ALA A 1 345 ? 160.164 167.779 186.469 1.00 52.05  ?  334 ALA A CA  1 
ATOM   1365 C C   . ALA A 1 345 ? 159.316 167.398 185.267 1.00 52.05  ?  334 ALA A C   1 
ATOM   1366 O O   . ALA A 1 345 ? 159.852 166.848 184.296 1.00 52.05  ?  334 ALA A O   1 
ATOM   1367 C CB  . ALA A 1 345 ? 160.144 166.660 187.504 1.00 52.05  ?  334 ALA A CB  1 
ATOM   1368 N N   . LEU A 1 346 ? 158.008 167.689 185.313 1.00 47.95  ?  335 LEU A N   1 
ATOM   1369 C CA  . LEU A 1 346 ? 157.132 167.431 184.171 1.00 47.95  ?  335 LEU A CA  1 
ATOM   1370 C C   . LEU A 1 346 ? 157.599 168.188 182.942 1.00 47.95  ?  335 LEU A C   1 
ATOM   1371 O O   . LEU A 1 346 ? 157.705 167.620 181.852 1.00 47.95  ?  335 LEU A O   1 
ATOM   1372 C CB  . LEU A 1 346 ? 155.701 167.839 184.491 1.00 47.95  ?  335 LEU A CB  1 
ATOM   1373 C CG  . LEU A 1 346 ? 154.869 167.133 185.547 1.00 47.95  ?  335 LEU A CG  1 
ATOM   1374 C CD1 . LEU A 1 346 ? 153.433 167.400 185.260 1.00 47.95  ?  335 LEU A CD1 1 
ATOM   1375 C CD2 . LEU A 1 346 ? 155.131 165.670 185.567 1.00 47.95  ?  335 LEU A CD2 1 
ATOM   1376 N N   . GLU A 1 347 ? 157.927 169.467 183.123 1.00 54.04  ?  336 GLU A N   1 
ATOM   1377 C CA  . GLU A 1 347 ? 158.386 170.320 182.031 1.00 54.04  ?  336 GLU A CA  1 
ATOM   1378 C C   . GLU A 1 347 ? 159.719 169.846 181.476 1.00 54.04  ?  336 GLU A C   1 
ATOM   1379 O O   . GLU A 1 347 ? 159.884 169.712 180.253 1.00 54.04  ?  336 GLU A O   1 
ATOM   1380 C CB  . GLU A 1 347 ? 158.503 171.756 182.534 1.00 54.04  ?  336 GLU A CB  1 
ATOM   1381 C CG  . GLU A 1 347 ? 159.045 172.723 181.521 1.00 54.04  ?  336 GLU A CG  1 
ATOM   1382 C CD  . GLU A 1 347 ? 158.103 172.954 180.365 1.00 54.04  ?  336 GLU A CD  1 
ATOM   1383 O OE1 . GLU A 1 347 ? 156.875 172.845 180.558 1.00 54.04  ?  336 GLU A OE1 1 
ATOM   1384 O OE2 . GLU A 1 347 ? 158.595 173.250 179.257 1.00 54.04  -1 336 GLU A OE2 1 
ATOM   1385 N N   . PHE A 1 348 ? 160.671 169.567 182.374 1.00 51.55  ?  337 PHE A N   1 
ATOM   1386 C CA  . PHE A 1 348 ? 162.016 169.161 181.970 1.00 51.55  ?  337 PHE A CA  1 
ATOM   1387 C C   . PHE A 1 348 ? 161.995 167.849 181.196 1.00 51.55  ?  337 PHE A C   1 
ATOM   1388 O O   . PHE A 1 348 ? 162.628 167.726 180.141 1.00 51.55  ?  337 PHE A O   1 
ATOM   1389 C CB  . PHE A 1 348 ? 162.896 169.039 183.209 1.00 51.55  ?  337 PHE A CB  1 
ATOM   1390 C CG  . PHE A 1 348 ? 164.320 168.721 182.915 1.00 51.55  ?  337 PHE A CG  1 
ATOM   1391 C CD1 . PHE A 1 348 ? 165.144 169.668 182.353 1.00 51.55  ?  337 PHE A CD1 1 
ATOM   1392 C CD2 . PHE A 1 348 ? 164.844 167.478 183.219 1.00 51.55  ?  337 PHE A CD2 1 
ATOM   1393 C CE1 . PHE A 1 348 ? 166.459 169.384 182.084 1.00 51.55  ?  337 PHE A CE1 1 
ATOM   1394 C CE2 . PHE A 1 348 ? 166.168 167.185 182.955 1.00 51.55  ?  337 PHE A CE2 1 
ATOM   1395 C CZ  . PHE A 1 348 ? 166.972 168.140 182.384 1.00 51.55  ?  337 PHE A CZ  1 
ATOM   1396 N N   . TRP A 1 349 ? 161.221 166.875 181.668 1.00 42.28  ?  338 TRP A N   1 
ATOM   1397 C CA  . TRP A 1 349 ? 161.228 165.586 180.997 1.00 42.28  ?  338 TRP A CA  1 
ATOM   1398 C C   . TRP A 1 349 ? 160.327 165.567 179.772 1.00 42.28  ?  338 TRP A C   1 
ATOM   1399 O O   . TRP A 1 349 ? 160.560 164.769 178.860 1.00 42.28  ?  338 TRP A O   1 
ATOM   1400 C CB  . TRP A 1 349 ? 160.854 164.487 181.987 1.00 42.28  ?  338 TRP A CB  1 
ATOM   1401 C CG  . TRP A 1 349 ? 161.945 164.217 182.953 1.00 42.28  ?  338 TRP A CG  1 
ATOM   1402 C CD1 . TRP A 1 349 ? 161.946 164.502 184.270 1.00 42.28  ?  338 TRP A CD1 1 
ATOM   1403 C CD2 . TRP A 1 349 ? 163.210 163.631 182.668 1.00 42.28  ?  338 TRP A CD2 1 
ATOM   1404 N NE1 . TRP A 1 349 ? 163.130 164.136 184.836 1.00 42.28  ?  338 TRP A NE1 1 
ATOM   1405 C CE2 . TRP A 1 349 ? 163.926 163.590 183.869 1.00 42.28  ?  338 TRP A CE2 1 
ATOM   1406 C CE3 . TRP A 1 349 ? 163.809 163.130 181.509 1.00 42.28  ?  338 TRP A CE3 1 
ATOM   1407 C CZ2 . TRP A 1 349 ? 165.203 163.071 183.949 1.00 42.28  ?  338 TRP A CZ2 1 
ATOM   1408 C CZ3 . TRP A 1 349 ? 165.073 162.628 181.591 1.00 42.28  ?  338 TRP A CZ3 1 
ATOM   1409 C CH2 . TRP A 1 349 ? 165.757 162.597 182.798 1.00 42.28  ?  338 TRP A CH2 1 
ATOM   1410 N N   . LEU A 1 350 ? 159.319 166.438 179.709 1.00 43.47  ?  339 LEU A N   1 
ATOM   1411 C CA  . LEU A 1 350 ? 158.544 166.557 178.482 1.00 43.47  ?  339 LEU A CA  1 
ATOM   1412 C C   . LEU A 1 350 ? 159.359 167.202 177.377 1.00 43.47  ?  339 LEU A C   1 
ATOM   1413 O O   . LEU A 1 350 ? 159.218 166.828 176.208 1.00 43.47  ?  339 LEU A O   1 
ATOM   1414 C CB  . LEU A 1 350 ? 157.275 167.365 178.740 1.00 43.47  ?  339 LEU A CB  1 
ATOM   1415 C CG  . LEU A 1 350 ? 156.048 166.563 179.149 1.00 43.47  ?  339 LEU A CG  1 
ATOM   1416 C CD1 . LEU A 1 350 ? 155.053 167.463 179.785 1.00 43.47  ?  339 LEU A CD1 1 
ATOM   1417 C CD2 . LEU A 1 350 ? 155.442 165.859 177.966 1.00 43.47  ?  339 LEU A CD2 1 
ATOM   1418 N N   . GLN A 1 351 ? 160.221 168.166 177.725 1.00 50.47  ?  340 GLN A N   1 
ATOM   1419 C CA  . GLN A 1 351 ? 161.115 168.738 176.725 1.00 50.47  ?  340 GLN A CA  1 
ATOM   1420 C C   . GLN A 1 351 ? 162.195 167.744 176.320 1.00 50.47  ?  340 GLN A C   1 
ATOM   1421 O O   . GLN A 1 351 ? 162.595 167.701 175.152 1.00 50.47  ?  340 GLN A O   1 
ATOM   1422 C CB  . GLN A 1 351 ? 161.739 170.026 177.252 1.00 50.47  ?  340 GLN A CB  1 
ATOM   1423 C CG  . GLN A 1 351 ? 160.847 171.233 177.114 1.00 50.47  ?  340 GLN A CG  1 
ATOM   1424 C CD  . GLN A 1 351 ? 161.047 171.974 175.808 1.00 50.47  ?  340 GLN A CD  1 
ATOM   1425 O OE1 . GLN A 1 351 ? 160.512 171.592 174.768 1.00 50.47  ?  340 GLN A OE1 1 
ATOM   1426 N NE2 . GLN A 1 351 ? 161.799 173.066 175.865 1.00 50.47  ?  340 GLN A NE2 1 
ATOM   1427 N N   . ALA A 1 352 ? 162.668 166.925 177.264 1.00 45.59  ?  341 ALA A N   1 
ATOM   1428 C CA  . ALA A 1 352 ? 163.647 165.900 176.918 1.00 45.59  ?  341 ALA A CA  1 
ATOM   1429 C C   . ALA A 1 352 ? 163.035 164.779 176.086 1.00 45.59  ?  341 ALA A C   1 
ATOM   1430 O O   . ALA A 1 352 ? 163.746 164.128 175.318 1.00 45.59  ?  341 ALA A O   1 
ATOM   1431 C CB  . ALA A 1 352 ? 164.295 165.341 178.180 1.00 45.59  ?  341 ALA A CB  1 
ATOM   1432 N N   . GLY A 1 353 ? 161.736 164.525 176.224 1.00 39.93  ?  342 GLY A N   1 
ATOM   1433 C CA  . GLY A 1 353 ? 161.041 163.725 175.234 1.00 39.93  ?  342 GLY A CA  1 
ATOM   1434 C C   . GLY A 1 353 ? 160.276 162.495 175.682 1.00 39.93  ?  342 GLY A C   1 
ATOM   1435 O O   . GLY A 1 353 ? 159.927 161.670 174.834 1.00 39.93  ?  342 GLY A O   1 
ATOM   1436 N N   . VAL A 1 354 ? 159.987 162.350 176.986 1.00 30.20  ?  343 VAL A N   1 
ATOM   1437 C CA  . VAL A 1 354 ? 159.235 161.193 177.463 1.00 30.20  ?  343 VAL A CA  1 
ATOM   1438 C C   . VAL A 1 354 ? 157.779 161.352 177.066 1.00 30.20  ?  343 VAL A C   1 
ATOM   1439 O O   . VAL A 1 354 ? 157.315 162.449 176.761 1.00 30.20  ?  343 VAL A O   1 
ATOM   1440 C CB  . VAL A 1 354 ? 159.381 160.994 178.984 1.00 30.20  ?  343 VAL A CB  1 
ATOM   1441 C CG1 . VAL A 1 354 ? 160.814 160.874 179.358 1.00 30.20  ?  343 VAL A CG1 1 
ATOM   1442 C CG2 . VAL A 1 354 ? 158.738 162.119 179.739 1.00 30.20  ?  343 VAL A CG2 1 
ATOM   1443 N N   . ASP A 1 355 ? 157.055 160.243 177.053 1.00 21.36  ?  344 ASP A N   1 
ATOM   1444 C CA  . ASP A 1 355 ? 155.721 160.201 176.485 1.00 21.36  ?  344 ASP A CA  1 
ATOM   1445 C C   . ASP A 1 355 ? 154.634 160.171 177.535 1.00 21.36  ?  344 ASP A C   1 
ATOM   1446 O O   . ASP A 1 355 ? 153.492 159.858 177.211 1.00 21.36  ?  344 ASP A O   1 
ATOM   1447 C CB  . ASP A 1 355 ? 155.593 158.993 175.576 1.00 21.36  ?  344 ASP A CB  1 
ATOM   1448 C CG  . ASP A 1 355 ? 156.657 158.961 174.506 1.00 21.36  ?  344 ASP A CG  1 
ATOM   1449 O OD1 . ASP A 1 355 ? 156.584 159.777 173.571 1.00 21.36  ?  344 ASP A OD1 1 
ATOM   1450 O OD2 . ASP A 1 355 ? 157.572 158.125 174.587 1.00 21.36  -1 344 ASP A OD2 1 
ATOM   1451 N N   . GLY A 1 356 ? 154.961 160.477 178.779 1.00 21.46  ?  345 GLY A N   1 
ATOM   1452 C CA  . GLY A 1 356 ? 153.999 160.347 179.848 1.00 21.46  ?  345 GLY A CA  1 
ATOM   1453 C C   . GLY A 1 356 ? 154.686 160.296 181.189 1.00 21.46  ?  345 GLY A C   1 
ATOM   1454 O O   . GLY A 1 356 ? 155.906 160.331 181.284 1.00 21.46  ?  345 GLY A O   1 
ATOM   1455 N N   . PHE A 1 357 ? 153.864 160.212 182.234 1.00 25.30  ?  346 PHE A N   1 
ATOM   1456 C CA  . PHE A 1 357 ? 154.356 160.154 183.603 1.00 25.30  ?  346 PHE A CA  1 
ATOM   1457 C C   . PHE A 1 357 ? 153.486 159.235 184.434 1.00 25.30  ?  346 PHE A C   1 
ATOM   1458 O O   . PHE A 1 357 ? 152.403 158.830 184.020 1.00 25.30  ?  346 PHE A O   1 
ATOM   1459 C CB  . PHE A 1 357 ? 154.402 161.528 184.264 1.00 25.30  ?  346 PHE A CB  1 
ATOM   1460 C CG  . PHE A 1 357 ? 155.337 162.463 183.604 1.00 25.30  ?  346 PHE A CG  1 
ATOM   1461 C CD1 . PHE A 1 357 ? 156.694 162.330 183.778 1.00 25.30  ?  346 PHE A CD1 1 
ATOM   1462 C CD2 . PHE A 1 357 ? 154.867 163.438 182.755 1.00 25.30  ?  346 PHE A CD2 1 
ATOM   1463 C CE1 . PHE A 1 357 ? 157.560 163.167 183.149 1.00 25.30  ?  346 PHE A CE1 1 
ATOM   1464 C CE2 . PHE A 1 357 ? 155.728 164.275 182.125 1.00 25.30  ?  346 PHE A CE2 1 
ATOM   1465 C CZ  . PHE A 1 357 ? 157.075 164.141 182.322 1.00 25.30  ?  346 PHE A CZ  1 
ATOM   1466 N N   . GLN A 1 358 ? 153.997 158.895 185.606 1.00 20.57  ?  347 GLN A N   1 
ATOM   1467 C CA  . GLN A 1 358 ? 153.267 158.149 186.612 1.00 20.57  ?  347 GLN A CA  1 
ATOM   1468 C C   . GLN A 1 358 ? 153.663 158.665 187.979 1.00 20.57  ?  347 GLN A C   1 
ATOM   1469 O O   . GLN A 1 358 ? 154.844 158.819 188.260 1.00 20.57  ?  347 GLN A O   1 
ATOM   1470 C CB  . GLN A 1 358 ? 153.545 156.656 186.511 1.00 20.57  ?  347 GLN A CB  1 
ATOM   1471 C CG  . GLN A 1 358 ? 153.239 155.883 187.771 1.00 20.57  ?  347 GLN A CG  1 
ATOM   1472 C CD  . GLN A 1 358 ? 153.175 154.415 187.554 1.00 20.57  ?  347 GLN A CD  1 
ATOM   1473 O OE1 . GLN A 1 358 ? 152.233 153.913 186.965 1.00 20.57  ?  347 GLN A OE1 1 
ATOM   1474 N NE2 . GLN A 1 358 ? 154.168 153.702 188.048 1.00 20.57  ?  347 GLN A NE2 1 
ATOM   1475 N N   . VAL A 1 359 ? 152.676 158.954 188.815 1.00 21.79  ?  348 VAL A N   1 
ATOM   1476 C CA  . VAL A 1 359 ? 152.896 159.278 190.218 1.00 21.79  ?  348 VAL A CA  1 
ATOM   1477 C C   . VAL A 1 359 ? 152.161 158.244 191.054 1.00 21.79  ?  348 VAL A C   1 
ATOM   1478 O O   . VAL A 1 359 ? 151.016 157.895 190.758 1.00 21.79  ?  348 VAL A O   1 
ATOM   1479 C CB  . VAL A 1 359 ? 152.441 160.709 190.560 1.00 21.79  ?  348 VAL A CB  1 
ATOM   1480 C CG1 . VAL A 1 359 ? 153.444 161.709 190.054 1.00 21.79  ?  348 VAL A CG1 1 
ATOM   1481 C CG2 . VAL A 1 359 ? 151.091 161.020 189.970 1.00 21.79  ?  348 VAL A CG2 1 
ATOM   1482 N N   . ARG A 1 360 ? 152.825 157.725 192.067 1.00 23.78  ?  349 ARG A N   1 
ATOM   1483 C CA  . ARG A 1 360 ? 152.257 156.662 192.869 1.00 23.78  ?  349 ARG A CA  1 
ATOM   1484 C C   . ARG A 1 360 ? 151.973 157.150 194.277 1.00 23.78  ?  349 ARG A C   1 
ATOM   1485 O O   . ARG A 1 360 ? 152.504 158.167 194.714 1.00 23.78  ?  349 ARG A O   1 
ATOM   1486 C CB  . ARG A 1 360 ? 153.190 155.461 192.913 1.00 23.78  ?  349 ARG A CB  1 
ATOM   1487 C CG  . ARG A 1 360 ? 153.074 154.540 191.733 1.00 23.78  ?  349 ARG A CG  1 
ATOM   1488 C CD  . ARG A 1 360 ? 153.749 153.229 192.010 1.00 23.78  ?  349 ARG A CD  1 
ATOM   1489 N NE  . ARG A 1 360 ? 155.196 153.351 191.974 1.00 23.78  ?  349 ARG A NE  1 
ATOM   1490 C CZ  . ARG A 1 360 ? 155.971 153.366 193.047 1.00 23.78  ?  349 ARG A CZ  1 
ATOM   1491 N NH1 . ARG A 1 360 ? 155.441 153.268 194.248 1.00 23.78  1  349 ARG A NH1 1 
ATOM   1492 N NH2 . ARG A 1 360 ? 157.274 153.493 192.917 1.00 23.78  ?  349 ARG A NH2 1 
ATOM   1493 N N   . ASP A 1 361 ? 151.093 156.412 194.954 1.00 30.62  ?  350 ASP A N   1 
ATOM   1494 C CA  . ASP A 1 361 ? 150.744 156.606 196.364 1.00 30.62  ?  350 ASP A CA  1 
ATOM   1495 C C   . ASP A 1 361 ? 150.161 157.991 196.627 1.00 30.62  ?  350 ASP A C   1 
ATOM   1496 O O   . ASP A 1 361 ? 150.578 158.704 197.532 1.00 30.62  ?  350 ASP A O   1 
ATOM   1497 C CB  . ASP A 1 361 ? 151.943 156.328 197.270 1.00 30.62  ?  350 ASP A CB  1 
ATOM   1498 C CG  . ASP A 1 361 ? 152.285 154.866 197.337 1.00 30.62  ?  350 ASP A CG  1 
ATOM   1499 O OD1 . ASP A 1 361 ? 151.519 154.115 197.969 1.00 30.62  ?  350 ASP A OD1 1 
ATOM   1500 O OD2 . ASP A 1 361 ? 153.310 154.461 196.750 1.00 30.62  -1 350 ASP A OD2 1 
ATOM   1501 N N   . ILE A 1 362 ? 149.155 158.362 195.831 1.00 30.69  ?  351 ILE A N   1 
ATOM   1502 C CA  . ILE A 1 362 ? 148.538 159.680 195.942 1.00 30.69  ?  351 ILE A CA  1 
ATOM   1503 C C   . ILE A 1 362 ? 147.594 159.791 197.123 1.00 30.69  ?  351 ILE A C   1 
ATOM   1504 O O   . ILE A 1 362 ? 147.022 160.863 197.349 1.00 30.69  ?  351 ILE A O   1 
ATOM   1505 C CB  . ILE A 1 362 ? 147.769 160.038 194.657 1.00 30.69  ?  351 ILE A CB  1 
ATOM   1506 C CG1 . ILE A 1 362 ? 146.674 159.011 194.405 1.00 30.69  ?  351 ILE A CG1 1 
ATOM   1507 C CG2 . ILE A 1 362 ? 148.711 160.135 193.486 1.00 30.69  ?  351 ILE A CG2 1 
ATOM   1508 C CD1 . ILE A 1 362 ? 145.766 159.353 193.283 1.00 30.69  ?  351 ILE A CD1 1 
ATOM   1509 N N   . GLU A 1 363 ? 147.394 158.719 197.876 1.00 37.24  ?  352 GLU A N   1 
ATOM   1510 C CA  . GLU A 1 363 ? 146.671 158.820 199.131 1.00 37.24  ?  352 GLU A CA  1 
ATOM   1511 C C   . GLU A 1 363 ? 147.549 159.321 200.271 1.00 37.24  ?  352 GLU A C   1 
ATOM   1512 O O   . GLU A 1 363 ? 147.021 159.704 201.314 1.00 37.24  ?  352 GLU A O   1 
ATOM   1513 C CB  . GLU A 1 363 ? 146.063 157.465 199.479 1.00 37.24  ?  352 GLU A CB  1 
ATOM   1514 C CG  . GLU A 1 363 ? 147.012 156.508 200.144 1.00 37.24  ?  352 GLU A CG  1 
ATOM   1515 C CD  . GLU A 1 363 ? 147.972 155.848 199.179 1.00 37.24  ?  352 GLU A CD  1 
ATOM   1516 O OE1 . GLU A 1 363 ? 147.778 155.966 197.956 1.00 37.24  ?  352 GLU A OE1 1 
ATOM   1517 O OE2 . GLU A 1 363 ? 148.919 155.190 199.645 1.00 37.24  -1 352 GLU A OE2 1 
ATOM   1518 N N   . ASN A 1 364 ? 148.866 159.322 200.099 1.00 38.96  ?  353 ASN A N   1 
ATOM   1519 C CA  . ASN A 1 364 ? 149.783 159.958 201.031 1.00 38.96  ?  353 ASN A CA  1 
ATOM   1520 C C   . ASN A 1 364 ? 150.079 161.397 200.662 1.00 38.96  ?  353 ASN A C   1 
ATOM   1521 O O   . ASN A 1 364 ? 150.928 162.017 201.301 1.00 38.96  ?  353 ASN A O   1 
ATOM   1522 C CB  . ASN A 1 364 ? 151.111 159.206 201.095 1.00 38.96  ?  353 ASN A CB  1 
ATOM   1523 C CG  . ASN A 1 364 ? 150.957 157.783 201.529 1.00 38.96  ?  353 ASN A CG  1 
ATOM   1524 O OD1 . ASN A 1 364 ? 151.705 156.912 201.098 1.00 38.96  ?  353 ASN A OD1 1 
ATOM   1525 N ND2 . ASN A 1 364 ? 149.989 157.530 202.394 1.00 38.96  ?  353 ASN A ND2 1 
ATOM   1526 N N   . LEU A 1 365 ? 149.446 161.925 199.626 1.00 40.71  ?  354 LEU A N   1 
ATOM   1527 C CA  . LEU A 1 365 ? 149.669 163.296 199.197 1.00 40.71  ?  354 LEU A CA  1 
ATOM   1528 C C   . LEU A 1 365 ? 148.448 164.122 199.570 1.00 40.71  ?  354 LEU A C   1 
ATOM   1529 O O   . LEU A 1 365 ? 147.341 163.835 199.107 1.00 40.71  ?  354 LEU A O   1 
ATOM   1530 C CB  . LEU A 1 365 ? 149.923 163.347 197.694 1.00 40.71  ?  354 LEU A CB  1 
ATOM   1531 C CG  . LEU A 1 365 ? 150.009 164.696 196.997 1.00 40.71  ?  354 LEU A CG  1 
ATOM   1532 C CD1 . LEU A 1 365 ? 151.285 165.394 197.365 1.00 40.71  ?  354 LEU A CD1 1 
ATOM   1533 C CD2 . LEU A 1 365 ? 149.944 164.513 195.512 1.00 40.71  ?  354 LEU A CD2 1 
ATOM   1534 N N   . LYS A 1 366 ? 148.635 165.116 200.433 1.00 49.43  ?  355 LYS A N   1 
ATOM   1535 C CA  . LYS A 1 366 ? 147.531 165.999 200.781 1.00 49.43  ?  355 LYS A CA  1 
ATOM   1536 C C   . LYS A 1 366 ? 147.294 166.977 199.647 1.00 49.43  ?  355 LYS A C   1 
ATOM   1537 O O   . LYS A 1 366 ? 148.233 167.355 198.941 1.00 49.43  ?  355 LYS A O   1 
ATOM   1538 C CB  . LYS A 1 366 ? 147.823 166.752 202.075 1.00 49.43  ?  355 LYS A CB  1 
ATOM   1539 C CG  . LYS A 1 366 ? 147.836 165.885 203.315 1.00 49.43  ?  355 LYS A CG  1 
ATOM   1540 C CD  . LYS A 1 366 ? 148.360 166.664 204.510 1.00 49.43  ?  355 LYS A CD  1 
ATOM   1541 C CE  . LYS A 1 366 ? 149.100 165.763 205.495 1.00 49.43  ?  355 LYS A CE  1 
ATOM   1542 N NZ  . LYS A 1 366 ? 150.582 165.938 205.440 1.00 49.43  1  355 LYS A NZ  1 
ATOM   1543 N N   . ASP A 1 367 ? 146.032 167.394 199.495 1.00 51.23  ?  356 ASP A N   1 
ATOM   1544 C CA  . ASP A 1 367 ? 145.526 168.133 198.335 1.00 51.23  ?  356 ASP A CA  1 
ATOM   1545 C C   . ASP A 1 367 ? 145.841 167.381 197.040 1.00 51.23  ?  356 ASP A C   1 
ATOM   1546 O O   . ASP A 1 367 ? 146.523 167.872 196.150 1.00 51.23  ?  356 ASP A O   1 
ATOM   1547 C CB  . ASP A 1 367 ? 146.076 169.567 198.281 1.00 51.23  ?  356 ASP A CB  1 
ATOM   1548 C CG  . ASP A 1 367 ? 145.109 170.588 198.829 1.00 51.23  ?  356 ASP A CG  1 
ATOM   1549 O OD1 . ASP A 1 367 ? 143.938 170.229 199.063 1.00 51.23  ?  356 ASP A OD1 1 
ATOM   1550 O OD2 . ASP A 1 367 ? 145.520 171.751 199.019 1.00 51.23  -1 356 ASP A OD2 1 
ATOM   1551 N N   . ALA A 1 368 ? 145.328 166.154 196.975 1.00 46.64  ?  357 ALA A N   1 
ATOM   1552 C CA  . ALA A 1 368 ? 145.631 165.281 195.846 1.00 46.64  ?  357 ALA A CA  1 
ATOM   1553 C C   . ALA A 1 368 ? 144.927 165.745 194.578 1.00 46.64  ?  357 ALA A C   1 
ATOM   1554 O O   . ALA A 1 368 ? 145.560 165.918 193.533 1.00 46.64  ?  357 ALA A O   1 
ATOM   1555 C CB  . ALA A 1 368 ? 145.244 163.845 196.183 1.00 46.64  ?  357 ALA A CB  1 
ATOM   1556 N N   . SER A 1 369 ? 143.618 165.993 194.666 1.00 45.33  ?  358 SER A N   1 
ATOM   1557 C CA  . SER A 1 369 ? 142.809 166.310 193.496 1.00 45.33  ?  358 SER A CA  1 
ATOM   1558 C C   . SER A 1 369 ? 143.155 167.655 192.883 1.00 45.33  ?  358 SER A C   1 
ATOM   1559 O O   . SER A 1 369 ? 142.787 167.910 191.734 1.00 45.33  ?  358 SER A O   1 
ATOM   1560 C CB  . SER A 1 369 ? 141.334 166.308 193.870 1.00 45.33  ?  358 SER A CB  1 
ATOM   1561 O OG  . SER A 1 369 ? 140.935 165.047 194.352 1.00 45.33  ?  358 SER A OG  1 
ATOM   1562 N N   . SER A 1 370 ? 143.844 168.517 193.622 1.00 48.20  ?  359 SER A N   1 
ATOM   1563 C CA  . SER A 1 370 ? 144.234 169.808 193.082 1.00 48.20  ?  359 SER A CA  1 
ATOM   1564 C C   . SER A 1 370 ? 145.520 169.704 192.281 1.00 48.20  ?  359 SER A C   1 
ATOM   1565 O O   . SER A 1 370 ? 145.621 170.266 191.186 1.00 48.20  ?  359 SER A O   1 
ATOM   1566 C CB  . SER A 1 370 ? 144.392 170.802 194.221 1.00 48.20  ?  359 SER A CB  1 
ATOM   1567 O OG  . SER A 1 370 ? 143.318 170.671 195.128 1.00 48.20  ?  359 SER A OG  1 
ATOM   1568 N N   . PHE A 1 371 ? 146.516 168.992 192.811 1.00 47.03  ?  360 PHE A N   1 
ATOM   1569 C CA  . PHE A 1 371 ? 147.789 168.831 192.119 1.00 47.03  ?  360 PHE A CA  1 
ATOM   1570 C C   . PHE A 1 371 ? 147.659 167.947 190.895 1.00 47.03  ?  360 PHE A C   1 
ATOM   1571 O O   . PHE A 1 371 ? 148.379 168.151 189.912 1.00 47.03  ?  360 PHE A O   1 
ATOM   1572 C CB  . PHE A 1 371 ? 148.831 168.240 193.060 1.00 47.03  ?  360 PHE A CB  1 
ATOM   1573 C CG  . PHE A 1 371 ? 149.277 169.170 194.128 1.00 47.03  ?  360 PHE A CG  1 
ATOM   1574 C CD1 . PHE A 1 371 ? 149.548 170.493 193.839 1.00 47.03  ?  360 PHE A CD1 1 
ATOM   1575 C CD2 . PHE A 1 371 ? 149.442 168.721 195.422 1.00 47.03  ?  360 PHE A CD2 1 
ATOM   1576 C CE1 . PHE A 1 371 ? 149.961 171.355 194.827 1.00 47.03  ?  360 PHE A CE1 1 
ATOM   1577 C CE2 . PHE A 1 371 ? 149.852 169.575 196.417 1.00 47.03  ?  360 PHE A CE2 1 
ATOM   1578 C CZ  . PHE A 1 371 ? 150.114 170.891 196.122 1.00 47.03  ?  360 PHE A CZ  1 
ATOM   1579 N N   . LEU A 1 372 ? 146.749 166.975 190.937 1.00 41.58  ?  361 LEU A N   1 
ATOM   1580 C CA  . LEU A 1 372 ? 146.555 166.096 189.795 1.00 41.58  ?  361 LEU A CA  1 
ATOM   1581 C C   . LEU A 1 372 ? 145.979 166.858 188.616 1.00 41.58  ?  361 LEU A C   1 
ATOM   1582 O O   . LEU A 1 372 ? 146.380 166.625 187.471 1.00 41.58  ?  361 LEU A O   1 
ATOM   1583 C CB  . LEU A 1 372 ? 145.658 164.922 190.176 1.00 41.58  ?  361 LEU A CB  1 
ATOM   1584 C CG  . LEU A 1 372 ? 146.319 163.753 190.913 1.00 41.58  ?  361 LEU A CG  1 
ATOM   1585 C CD1 . LEU A 1 372 ? 145.281 162.738 191.290 1.00 41.58  ?  361 LEU A CD1 1 
ATOM   1586 C CD2 . LEU A 1 372 ? 147.401 163.116 190.082 1.00 41.58  ?  361 LEU A CD2 1 
ATOM   1587 N N   . ALA A 1 373 ? 145.087 167.816 188.886 1.00 47.39  ?  362 ALA A N   1 
ATOM   1588 C CA  . ALA A 1 373 ? 144.500 168.627 187.823 1.00 47.39  ?  362 ALA A CA  1 
ATOM   1589 C C   . ALA A 1 373 ? 145.534 169.538 187.185 1.00 47.39  ?  362 ALA A C   1 
ATOM   1590 O O   . ALA A 1 373 ? 145.565 169.679 185.959 1.00 47.39  ?  362 ALA A O   1 
ATOM   1591 C CB  . ALA A 1 373 ? 143.341 169.449 188.369 1.00 47.39  ?  362 ALA A CB  1 
ATOM   1592 N N   . GLU A 1 374 ? 146.420 170.112 187.997 1.00 49.01  ?  363 GLU A N   1 
ATOM   1593 C CA  . GLU A 1 374 ? 147.474 170.983 187.486 1.00 49.01  ?  363 GLU A CA  1 
ATOM   1594 C C   . GLU A 1 374 ? 148.484 170.213 186.640 1.00 49.01  ?  363 GLU A C   1 
ATOM   1595 O O   . GLU A 1 374 ? 148.865 170.663 185.550 1.00 49.01  ?  363 GLU A O   1 
ATOM   1596 C CB  . GLU A 1 374 ? 148.163 171.657 188.665 1.00 49.01  ?  363 GLU A CB  1 
ATOM   1597 C CG  . GLU A 1 374 ? 148.750 173.012 188.394 1.00 49.01  ?  363 GLU A CG  1 
ATOM   1598 C CD  . GLU A 1 374 ? 148.990 173.778 189.675 1.00 49.01  ?  363 GLU A CD  1 
ATOM   1599 O OE1 . GLU A 1 374 ? 148.341 173.462 190.691 1.00 49.01  ?  363 GLU A OE1 1 
ATOM   1600 O OE2 . GLU A 1 374 ? 149.853 174.674 189.676 1.00 49.01  -1 363 GLU A OE2 1 
ATOM   1601 N N   . TRP A 1 375 ? 148.909 169.036 187.115 1.00 44.18  ?  364 TRP A N   1 
ATOM   1602 C CA  . TRP A 1 375 ? 149.879 168.232 186.379 1.00 44.18  ?  364 TRP A CA  1 
ATOM   1603 C C   . TRP A 1 375 ? 149.278 167.669 185.098 1.00 44.18  ?  364 TRP A C   1 
ATOM   1604 O O   . TRP A 1 375 ? 149.951 167.618 184.059 1.00 44.18  ?  364 TRP A O   1 
ATOM   1605 C CB  . TRP A 1 375 ? 150.382 167.110 187.272 1.00 44.18  ?  364 TRP A CB  1 
ATOM   1606 C CG  . TRP A 1 375 ? 151.103 167.579 188.485 1.00 44.18  ?  364 TRP A CG  1 
ATOM   1607 C CD1 . TRP A 1 375 ? 151.740 168.764 188.650 1.00 44.18  ?  364 TRP A CD1 1 
ATOM   1608 C CD2 . TRP A 1 375 ? 151.265 166.863 189.711 1.00 44.18  ?  364 TRP A CD2 1 
ATOM   1609 N NE1 . TRP A 1 375 ? 152.282 168.837 189.900 1.00 44.18  ?  364 TRP A NE1 1 
ATOM   1610 C CE2 . TRP A 1 375 ? 152.011 167.677 190.569 1.00 44.18  ?  364 TRP A CE2 1 
ATOM   1611 C CE3 . TRP A 1 375 ? 150.857 165.606 190.159 1.00 44.18  ?  364 TRP A CE3 1 
ATOM   1612 C CZ2 . TRP A 1 375 ? 152.343 167.288 191.848 1.00 44.18  ?  364 TRP A CZ2 1 
ATOM   1613 C CZ3 . TRP A 1 375 ? 151.187 165.224 191.421 1.00 44.18  ?  364 TRP A CZ3 1 
ATOM   1614 C CH2 . TRP A 1 375 ? 151.929 166.057 192.254 1.00 44.18  ?  364 TRP A CH2 1 
ATOM   1615 N N   . GLN A 1 376 ? 148.006 167.267 185.152 1.00 42.06  ?  365 GLN A N   1 
ATOM   1616 C CA  . GLN A 1 376 ? 147.280 166.839 183.966 1.00 42.06  ?  365 GLN A CA  1 
ATOM   1617 C C   . GLN A 1 376 ? 147.148 167.972 182.962 1.00 42.06  ?  365 GLN A C   1 
ATOM   1618 O O   . GLN A 1 376 ? 147.257 167.748 181.753 1.00 42.06  ?  365 GLN A O   1 
ATOM   1619 C CB  . GLN A 1 376 ? 145.914 166.312 184.393 1.00 42.06  ?  365 GLN A CB  1 
ATOM   1620 C CG  . GLN A 1 376 ? 144.909 166.129 183.297 1.00 42.06  ?  365 GLN A CG  1 
ATOM   1621 C CD  . GLN A 1 376 ? 145.066 164.834 182.575 1.00 42.06  ?  365 GLN A CD  1 
ATOM   1622 O OE1 . GLN A 1 376 ? 145.658 164.776 181.510 1.00 42.06  ?  365 GLN A OE1 1 
ATOM   1623 N NE2 . GLN A 1 376 ? 144.524 163.779 183.143 1.00 42.06  ?  365 GLN A NE2 1 
ATOM   1624 N N   . ASN A 1 377 ? 146.959 169.201 183.453 1.00 54.24  ?  366 ASN A N   1 
ATOM   1625 C CA  . ASN A 1 377 ? 146.904 170.370 182.584 1.00 54.24  ?  366 ASN A CA  1 
ATOM   1626 C C   . ASN A 1 377 ? 148.211 170.618 181.859 1.00 54.24  ?  366 ASN A C   1 
ATOM   1627 O O   . ASN A 1 377 ? 148.204 170.873 180.657 1.00 54.24  ?  366 ASN A O   1 
ATOM   1628 C CB  . ASN A 1 377 ? 146.573 171.611 183.380 1.00 54.24  ?  366 ASN A CB  1 
ATOM   1629 C CG  . ASN A 1 377 ? 145.164 172.034 183.224 1.00 54.24  ?  366 ASN A CG  1 
ATOM   1630 O OD1 . ASN A 1 377 ? 144.369 171.399 182.538 1.00 54.24  ?  366 ASN A OD1 1 
ATOM   1631 N ND2 . ASN A 1 377 ? 144.861 173.159 183.819 1.00 54.24  ?  366 ASN A ND2 1 
ATOM   1632 N N   . ILE A 1 378 ? 149.327 170.594 182.585 1.00 41.59  ?  367 ILE A N   1 
ATOM   1633 C CA  . ILE A 1 378 ? 150.632 170.852 181.976 1.00 41.59  ?  367 ILE A CA  1 
ATOM   1634 C C   . ILE A 1 378 ? 150.970 169.781 180.947 1.00 41.59  ?  367 ILE A C   1 
ATOM   1635 O O   . ILE A 1 378 ? 151.413 170.077 179.826 1.00 41.59  ?  367 ILE A O   1 
ATOM   1636 C CB  . ILE A 1 378 ? 151.706 170.937 183.069 1.00 41.59  ?  367 ILE A CB  1 
ATOM   1637 C CG1 . ILE A 1 378 ? 151.389 172.086 184.017 1.00 41.59  ?  367 ILE A CG1 1 
ATOM   1638 C CG2 . ILE A 1 378 ? 153.073 171.107 182.462 1.00 41.59  ?  367 ILE A CG2 1 
ATOM   1639 C CD1 . ILE A 1 378 ? 152.082 171.981 185.340 1.00 41.59  ?  367 ILE A CD1 1 
ATOM   1640 N N   . THR A 1 379 ? 150.707 168.524 181.299 1.00 40.65  ?  368 THR A N   1 
ATOM   1641 C CA  . THR A 1 379 ? 150.965 167.406 180.408 1.00 40.65  ?  368 THR A CA  1 
ATOM   1642 C C   . THR A 1 379 ? 150.085 167.422 179.163 1.00 40.65  ?  368 THR A C   1 
ATOM   1643 O O   . THR A 1 379 ? 150.607 167.225 178.065 1.00 40.65  ?  368 THR A O   1 
ATOM   1644 C CB  . THR A 1 379 ? 150.796 166.120 181.202 1.00 40.65  ?  368 THR A CB  1 
ATOM   1645 O OG1 . THR A 1 379 ? 151.580 166.220 182.393 1.00 40.65  ?  368 THR A OG1 1 
ATOM   1646 C CG2 . THR A 1 379 ? 151.264 164.945 180.428 1.00 40.65  ?  368 THR A CG2 1 
ATOM   1647 N N   . LYS A 1 380 ? 148.787 167.709 179.286 1.00 43.11  ?  369 LYS A N   1 
ATOM   1648 C CA  . LYS A 1 380 ? 147.951 167.888 178.104 1.00 43.11  ?  369 LYS A CA  1 
ATOM   1649 C C   . LYS A 1 380 ? 148.249 169.165 177.332 1.00 43.11  ?  369 LYS A C   1 
ATOM   1650 O O   . LYS A 1 380 ? 147.975 169.218 176.131 1.00 43.11  ?  369 LYS A O   1 
ATOM   1651 C CB  . LYS A 1 380 ? 146.465 167.907 178.473 1.00 43.11  ?  369 LYS A CB  1 
ATOM   1652 C CG  . LYS A 1 380 ? 145.868 166.558 178.760 1.00 43.11  ?  369 LYS A CG  1 
ATOM   1653 C CD  . LYS A 1 380 ? 146.270 165.536 177.715 1.00 43.11  ?  369 LYS A CD  1 
ATOM   1654 C CE  . LYS A 1 380 ? 146.189 164.137 178.270 1.00 43.11  ?  369 LYS A CE  1 
ATOM   1655 N NZ  . LYS A 1 380 ? 146.203 163.134 177.186 1.00 43.11  1  369 LYS A NZ  1 
ATOM   1656 N N   . GLY A 1 381 ? 148.787 170.197 177.983 1.00 43.11  ?  370 GLY A N   1 
ATOM   1657 C CA  . GLY A 1 381 ? 149.091 171.423 177.286 1.00 43.11  ?  370 GLY A CA  1 
ATOM   1658 C C   . GLY A 1 381 ? 150.325 171.340 176.429 1.00 43.11  ?  370 GLY A C   1 
ATOM   1659 O O   . GLY A 1 381 ? 150.405 172.042 175.418 1.00 43.11  ?  370 GLY A O   1 
ATOM   1660 N N   . PHE A 1 382 ? 151.295 170.512 176.815 1.00 43.50  ?  371 PHE A N   1 
ATOM   1661 C CA  . PHE A 1 382 ? 152.427 170.253 175.930 1.00 43.50  ?  371 PHE A CA  1 
ATOM   1662 C C   . PHE A 1 382 ? 151.964 169.583 174.641 1.00 43.50  ?  371 PHE A C   1 
ATOM   1663 O O   . PHE A 1 382 ? 152.181 170.103 173.544 1.00 43.50  ?  371 PHE A O   1 
ATOM   1664 C CB  . PHE A 1 382 ? 153.461 169.395 176.646 1.00 43.50  ?  371 PHE A CB  1 
ATOM   1665 C CG  . PHE A 1 382 ? 154.828 169.467 176.056 1.00 43.50  ?  371 PHE A CG  1 
ATOM   1666 C CD1 . PHE A 1 382 ? 155.160 168.707 174.948 1.00 43.50  ?  371 PHE A CD1 1 
ATOM   1667 C CD2 . PHE A 1 382 ? 155.794 170.264 176.626 1.00 43.50  ?  371 PHE A CD2 1 
ATOM   1668 C CE1 . PHE A 1 382 ? 156.411 168.768 174.404 1.00 43.50  ?  371 PHE A CE1 1 
ATOM   1669 C CE2 . PHE A 1 382 ? 157.055 170.321 176.093 1.00 43.50  ?  371 PHE A CE2 1 
ATOM   1670 C CZ  . PHE A 1 382 ? 157.361 169.572 174.977 1.00 43.50  ?  371 PHE A CZ  1 
ATOM   1671 N N   . SER A 1 383 ? 151.317 168.430 174.754 1.00 40.68  ?  372 SER A N   1 
ATOM   1672 C CA  . SER A 1 383 ? 150.707 167.799 173.596 1.00 40.68  ?  372 SER A CA  1 
ATOM   1673 C C   . SER A 1 383 ? 149.522 166.981 174.073 1.00 40.68  ?  372 SER A C   1 
ATOM   1674 O O   . SER A 1 383 ? 149.327 166.789 175.272 1.00 40.68  ?  372 SER A O   1 
ATOM   1675 C CB  . SER A 1 383 ? 151.699 166.920 172.832 1.00 40.68  ?  372 SER A CB  1 
ATOM   1676 O OG  . SER A 1 383 ? 151.050 166.248 171.771 1.00 40.68  ?  372 SER A OG  1 
ATOM   1677 N N   . GLU A 1 384 ? 148.719 166.516 173.124 1.00 40.76  ?  373 GLU A N   1 
ATOM   1678 C CA  . GLU A 1 384 ? 147.551 165.733 173.486 1.00 40.76  ?  373 GLU A CA  1 
ATOM   1679 C C   . GLU A 1 384 ? 147.784 164.238 173.365 1.00 40.76  ?  373 GLU A C   1 
ATOM   1680 O O   . GLU A 1 384 ? 146.902 163.457 173.738 1.00 40.76  ?  373 GLU A O   1 
ATOM   1681 C CB  . GLU A 1 384 ? 146.347 166.138 172.637 1.00 40.76  ?  373 GLU A CB  1 
ATOM   1682 C CG  . GLU A 1 384 ? 145.846 167.545 172.909 1.00 40.76  ?  373 GLU A CG  1 
ATOM   1683 C CD  . GLU A 1 384 ? 145.215 167.723 174.289 1.00 40.76  ?  373 GLU A CD  1 
ATOM   1684 O OE1 . GLU A 1 384 ? 144.573 166.783 174.805 1.00 40.76  ?  373 GLU A OE1 1 
ATOM   1685 O OE2 . GLU A 1 384 ? 145.363 168.823 174.858 1.00 40.76  -1 373 GLU A OE2 1 
ATOM   1686 N N   . ASP A 1 385 ? 148.939 163.816 172.854 1.00 34.64  ?  374 ASP A N   1 
ATOM   1687 C CA  . ASP A 1 385 ? 149.341 162.416 172.918 1.00 34.64  ?  374 ASP A CA  1 
ATOM   1688 C C   . ASP A 1 385 ? 150.301 162.156 174.070 1.00 34.64  ?  374 ASP A C   1 
ATOM   1689 O O   . ASP A 1 385 ? 151.196 161.324 173.978 1.00 34.64  ?  374 ASP A O   1 
ATOM   1690 C CB  . ASP A 1 385 ? 149.909 161.946 171.579 1.00 34.64  ?  374 ASP A CB  1 
ATOM   1691 C CG  . ASP A 1 385 ? 151.193 162.652 171.155 1.00 34.64  ?  374 ASP A CG  1 
ATOM   1692 O OD1 . ASP A 1 385 ? 151.703 163.559 171.838 1.00 34.64  ?  374 ASP A OD1 1 
ATOM   1693 O OD2 . ASP A 1 385 ? 151.688 162.307 170.064 1.00 34.64  -1 374 ASP A OD2 1 
ATOM   1694 N N   . ARG A 1 386 ? 150.136 162.884 175.161 1.00 29.78  ?  375 ARG A N   1 
ATOM   1695 C CA  . ARG A 1 386 ? 150.839 162.636 176.403 1.00 29.78  ?  375 ARG A CA  1 
ATOM   1696 C C   . ARG A 1 386 ? 149.876 162.053 177.420 1.00 29.78  ?  375 ARG A C   1 
ATOM   1697 O O   . ARG A 1 386 ? 148.663 162.191 177.297 1.00 29.78  ?  375 ARG A O   1 
ATOM   1698 C CB  . ARG A 1 386 ? 151.453 163.920 176.951 1.00 29.78  ?  375 ARG A CB  1 
ATOM   1699 C CG  . ARG A 1 386 ? 152.483 164.525 176.070 1.00 29.78  ?  375 ARG A CG  1 
ATOM   1700 C CD  . ARG A 1 386 ? 153.497 163.519 175.680 1.00 29.78  ?  375 ARG A CD  1 
ATOM   1701 N NE  . ARG A 1 386 ? 154.637 164.134 175.041 1.00 29.78  ?  375 ARG A NE  1 
ATOM   1702 C CZ  . ARG A 1 386 ? 155.003 163.894 173.794 1.00 29.78  ?  375 ARG A CZ  1 
ATOM   1703 N NH1 . ARG A 1 386 ? 154.312 163.050 173.051 1.00 29.78  1  375 ARG A NH1 1 
ATOM   1704 N NH2 . ARG A 1 386 ? 156.067 164.506 173.293 1.00 29.78  ?  375 ARG A NH2 1 
ATOM   1705 N N   . LEU A 1 387 ? 150.426 161.415 178.438 1.00 17.49  ?  376 LEU A N   1 
ATOM   1706 C CA  . LEU A 1 387 ? 149.644 160.659 179.395 1.00 17.49  ?  376 LEU A CA  1 
ATOM   1707 C C   . LEU A 1 387 ? 150.096 160.994 180.802 1.00 17.49  ?  376 LEU A C   1 
ATOM   1708 O O   . LEU A 1 387 ? 151.229 161.397 181.021 1.00 17.49  ?  376 LEU A O   1 
ATOM   1709 C CB  . LEU A 1 387 ? 149.787 159.169 179.123 1.00 17.49  ?  376 LEU A CB  1 
ATOM   1710 C CG  . LEU A 1 387 ? 149.001 158.120 179.888 1.00 17.49  ?  376 LEU A CG  1 
ATOM   1711 C CD1 . LEU A 1 387 ? 147.571 158.432 179.827 1.00 17.49  ?  376 LEU A CD1 1 
ATOM   1712 C CD2 . LEU A 1 387 ? 149.276 156.778 179.313 1.00 17.49  ?  376 LEU A CD2 1 
ATOM   1713 N N   . LEU A 1 388 ? 149.188 160.875 181.756 1.00 17.41  ?  377 LEU A N   1 
ATOM   1714 C CA  . LEU A 1 388 ? 149.534 160.920 183.165 1.00 17.41  ?  377 LEU A CA  1 
ATOM   1715 C C   . LEU A 1 388 ? 148.796 159.788 183.845 1.00 17.41  ?  377 LEU A C   1 
ATOM   1716 O O   . LEU A 1 388 ? 147.579 159.672 183.702 1.00 17.41  ?  377 LEU A O   1 
ATOM   1717 C CB  . LEU A 1 388 ? 149.162 162.263 183.790 1.00 17.41  ?  377 LEU A CB  1 
ATOM   1718 C CG  . LEU A 1 388 ? 149.532 162.425 185.262 1.00 17.41  ?  377 LEU A CG  1 
ATOM   1719 C CD1 . LEU A 1 388 ? 151.016 162.553 185.445 1.00 17.41  ?  377 LEU A CD1 1 
ATOM   1720 C CD2 . LEU A 1 388 ? 148.856 163.603 185.858 1.00 17.41  ?  377 LEU A CD2 1 
ATOM   1721 N N   . ILE A 1 389 ? 149.520 158.955 184.576 1.00 16.17  ?  378 ILE A N   1 
ATOM   1722 C CA  . ILE A 1 389 ? 148.937 157.864 185.341 1.00 16.17  ?  378 ILE A CA  1 
ATOM   1723 C C   . ILE A 1 389 ? 149.076 158.204 186.814 1.00 16.17  ?  378 ILE A C   1 
ATOM   1724 O O   . ILE A 1 389 ? 150.115 158.704 187.237 1.00 16.17  ?  378 ILE A O   1 
ATOM   1725 C CB  . ILE A 1 389 ? 149.636 156.533 185.020 1.00 16.17  ?  378 ILE A CB  1 
ATOM   1726 C CG1 . ILE A 1 389 ? 149.664 156.288 183.522 1.00 16.17  ?  378 ILE A CG1 1 
ATOM   1727 C CG2 . ILE A 1 389 ? 148.910 155.403 185.649 1.00 16.17  ?  378 ILE A CG2 1 
ATOM   1728 C CD1 . ILE A 1 389 ? 150.537 155.147 183.135 1.00 16.17  ?  378 ILE A CD1 1 
ATOM   1729 N N   . ALA A 1 390 ? 148.034 157.955 187.592 1.00 17.54  ?  379 ALA A N   1 
ATOM   1730 C CA  . ALA A 1 390 ? 148.095 158.086 189.035 1.00 17.54  ?  379 ALA A CA  1 
ATOM   1731 C C   . ALA A 1 390 ? 147.832 156.733 189.661 1.00 17.54  ?  379 ALA A C   1 
ATOM   1732 O O   . ALA A 1 390 ? 147.059 155.944 189.132 1.00 17.54  ?  379 ALA A O   1 
ATOM   1733 C CB  . ALA A 1 390 ? 147.088 159.093 189.540 1.00 17.54  ?  379 ALA A CB  1 
ATOM   1734 N N   . GLY A 1 391 ? 148.468 156.456 190.778 1.00 21.61  ?  380 GLY A N   1 
ATOM   1735 C CA  . GLY A 1 391 ? 148.271 155.204 191.489 1.00 21.61  ?  380 GLY A CA  1 
ATOM   1736 C C   . GLY A 1 391 ? 147.873 155.444 192.930 1.00 21.61  ?  380 GLY A C   1 
ATOM   1737 O O   . GLY A 1 391 ? 148.383 156.349 193.572 1.00 21.61  ?  380 GLY A O   1 
ATOM   1738 N N   . THR A 1 392 ? 146.970 154.614 193.431 1.00 27.45  ?  381 THR A N   1 
ATOM   1739 C CA  . THR A 1 392 ? 146.554 154.677 194.821 1.00 27.45  ?  381 THR A CA  1 
ATOM   1740 C C   . THR A 1 392 ? 146.453 153.263 195.370 1.00 27.45  ?  381 THR A C   1 
ATOM   1741 O O   . THR A 1 392 ? 146.372 152.295 194.617 1.00 27.45  ?  381 THR A O   1 
ATOM   1742 C CB  . THR A 1 392 ? 145.220 155.416 194.962 1.00 27.45  ?  381 THR A CB  1 
ATOM   1743 O OG1 . THR A 1 392 ? 144.832 155.443 196.334 1.00 27.45  ?  381 THR A OG1 1 
ATOM   1744 C CG2 . THR A 1 392 ? 144.137 154.732 194.171 1.00 27.45  ?  381 THR A CG2 1 
ATOM   1745 N N   . ASN A 1 393 ? 146.482 153.134 196.692 1.00 38.46  ?  382 ASN A N   1 
ATOM   1746 C CA  . ASN A 1 393 ? 146.287 151.826 197.303 1.00 38.46  ?  382 ASN A CA  1 
ATOM   1747 C C   . ASN A 1 393 ? 144.859 151.605 197.761 1.00 38.46  ?  382 ASN A C   1 
ATOM   1748 O O   . ASN A 1 393 ? 144.593 150.632 198.466 1.00 38.46  ?  382 ASN A O   1 
ATOM   1749 C CB  . ASN A 1 393 ? 147.265 151.610 198.465 1.00 38.46  ?  382 ASN A CB  1 
ATOM   1750 C CG  . ASN A 1 393 ? 146.867 152.327 199.751 1.00 38.46  ?  382 ASN A CG  1 
ATOM   1751 O OD1 . ASN A 1 393 ? 146.242 153.381 199.745 1.00 38.46  ?  382 ASN A OD1 1 
ATOM   1752 N ND2 . ASN A 1 393 ? 147.249 151.742 200.870 1.00 38.46  ?  382 ASN A ND2 1 
ATOM   1753 N N   . SER A 1 394 ? 143.945 152.476 197.356 1.00 35.15  ?  383 SER A N   1 
ATOM   1754 C CA  . SER A 1 394 ? 142.556 152.388 197.759 1.00 35.15  ?  383 SER A CA  1 
ATOM   1755 C C   . SER A 1 394 ? 141.889 151.194 197.106 1.00 35.15  ?  383 SER A C   1 
ATOM   1756 O O   . SER A 1 394 ? 142.383 150.632 196.134 1.00 35.15  ?  383 SER A O   1 
ATOM   1757 C CB  . SER A 1 394 ? 141.810 153.655 197.367 1.00 35.15  ?  383 SER A CB  1 
ATOM   1758 O OG  . SER A 1 394 ? 142.396 154.792 197.959 1.00 35.15  ?  383 SER A OG  1 
ATOM   1759 N N   . SER A 1 395 ? 140.764 150.801 197.665 1.00 37.37  ?  384 SER A N   1 
ATOM   1760 C CA  . SER A 1 395 ? 139.947 149.756 197.095 1.00 37.37  ?  384 SER A CA  1 
ATOM   1761 C C   . SER A 1 395 ? 138.477 150.096 197.125 1.00 37.37  ?  384 SER A C   1 
ATOM   1762 O O   . SER A 1 395 ? 137.669 149.294 196.654 1.00 37.37  ?  384 SER A O   1 
ATOM   1763 C CB  . SER A 1 395 ? 140.165 148.434 197.838 1.00 37.37  ?  384 SER A CB  1 
ATOM   1764 O OG  . SER A 1 395 ? 139.267 147.442 197.375 1.00 37.37  ?  384 SER A OG  1 
ATOM   1765 N N   . ASP A 1 396 ? 138.108 151.236 197.691 1.00 40.92  ?  385 ASP A N   1 
ATOM   1766 C CA  . ASP A 1 396 ? 136.731 151.674 197.806 1.00 40.92  ?  385 ASP A CA  1 
ATOM   1767 C C   . ASP A 1 396 ? 136.382 152.618 196.669 1.00 40.92  ?  385 ASP A C   1 
ATOM   1768 O O   . ASP A 1 396 ? 137.156 153.509 196.322 1.00 40.92  ?  385 ASP A O   1 
ATOM   1769 C CB  . ASP A 1 396 ? 136.498 152.358 199.153 1.00 40.92  ?  385 ASP A CB  1 
ATOM   1770 C CG  . ASP A 1 396 ? 137.643 153.275 199.551 1.00 40.92  ?  385 ASP A CG  1 
ATOM   1771 O OD1 . ASP A 1 396 ? 138.811 152.865 199.417 1.00 40.92  ?  385 ASP A OD1 1 
ATOM   1772 O OD2 . ASP A 1 396 ? 137.376 154.405 200.007 1.00 40.92  -1 385 ASP A OD2 1 
ATOM   1773 N N   . LEU A 1 397 ? 135.183 152.427 196.115 1.00 37.35  ?  386 LEU A N   1 
ATOM   1774 C CA  . LEU A 1 397 ? 134.791 153.104 194.886 1.00 37.35  ?  386 LEU A CA  1 
ATOM   1775 C C   . LEU A 1 397 ? 134.587 154.596 195.093 1.00 37.35  ?  386 LEU A C   1 
ATOM   1776 O O   . LEU A 1 397 ? 134.732 155.376 194.151 1.00 37.35  ?  386 LEU A O   1 
ATOM   1777 C CB  . LEU A 1 397 ? 133.528 152.449 194.337 1.00 37.35  ?  386 LEU A CB  1 
ATOM   1778 C CG  . LEU A 1 397 ? 132.919 152.890 193.003 1.00 37.35  ?  386 LEU A CG  1 
ATOM   1779 C CD1 . LEU A 1 397 ? 133.955 153.095 191.921 1.00 37.35  ?  386 LEU A CD1 1 
ATOM   1780 C CD2 . LEU A 1 397 ? 131.916 151.873 192.545 1.00 37.35  ?  386 LEU A CD2 1 
ATOM   1781 N N   . GLN A 1 398 ? 134.303 155.022 196.316 1.00 41.65  ?  387 GLN A N   1 
ATOM   1782 C CA  . GLN A 1 398 ? 133.954 156.419 196.531 1.00 41.65  ?  387 GLN A CA  1 
ATOM   1783 C C   . GLN A 1 398 ? 135.179 157.321 196.541 1.00 41.65  ?  387 GLN A C   1 
ATOM   1784 O O   . GLN A 1 398 ? 135.117 158.449 196.050 1.00 41.65  ?  387 GLN A O   1 
ATOM   1785 C CB  . GLN A 1 398 ? 133.151 156.550 197.819 1.00 41.65  ?  387 GLN A CB  1 
ATOM   1786 C CG  . GLN A 1 398 ? 132.165 155.423 198.017 1.00 41.65  ?  387 GLN A CG  1 
ATOM   1787 C CD  . GLN A 1 398 ? 131.062 155.405 196.976 1.00 41.65  ?  387 GLN A CD  1 
ATOM   1788 O OE1 . GLN A 1 398 ? 130.703 156.438 196.414 1.00 41.65  ?  387 GLN A OE1 1 
ATOM   1789 N NE2 . GLN A 1 398 ? 130.487 154.229 196.747 1.00 41.65  ?  387 GLN A NE2 1 
ATOM   1790 N N   . GLN A 1 399 ? 136.314 156.827 197.026 1.00 41.40  ?  388 GLN A N   1 
ATOM   1791 C CA  . GLN A 1 399 ? 137.546 157.605 196.944 1.00 41.40  ?  388 GLN A CA  1 
ATOM   1792 C C   . GLN A 1 399 ? 138.087 157.665 195.523 1.00 41.40  ?  388 GLN A C   1 
ATOM   1793 O O   . GLN A 1 399 ? 138.551 158.726 195.076 1.00 41.40  ?  388 GLN A O   1 
ATOM   1794 C CB  . GLN A 1 399 ? 138.585 156.994 197.861 1.00 41.40  ?  388 GLN A CB  1 
ATOM   1795 C CG  . GLN A 1 399 ? 139.477 157.979 198.531 1.00 41.40  ?  388 GLN A CG  1 
ATOM   1796 C CD  . GLN A 1 399 ? 140.009 157.420 199.816 1.00 41.40  ?  388 GLN A CD  1 
ATOM   1797 O OE1 . GLN A 1 399 ? 139.644 156.317 200.210 1.00 41.40  ?  388 GLN A OE1 1 
ATOM   1798 N NE2 . GLN A 1 399 ? 140.877 158.166 200.477 1.00 41.40  ?  388 GLN A NE2 1 
ATOM   1799 N N   . ILE A 1 400 ? 138.049 156.527 194.821 1.00 37.26  ?  389 ILE A N   1 
ATOM   1800 C CA  . ILE A 1 400 ? 138.450 156.442 193.421 1.00 37.26  ?  389 ILE A CA  1 
ATOM   1801 C C   . ILE A 1 400 ? 137.607 157.376 192.574 1.00 37.26  ?  389 ILE A C   1 
ATOM   1802 O O   . ILE A 1 400 ? 138.120 158.087 191.706 1.00 37.26  ?  389 ILE A O   1 
ATOM   1803 C CB  . ILE A 1 400 ? 138.346 154.980 192.950 1.00 37.26  ?  389 ILE A CB  1 
ATOM   1804 C CG1 . ILE A 1 400 ? 139.425 154.132 193.603 1.00 37.26  ?  389 ILE A CG1 1 
ATOM   1805 C CG2 . ILE A 1 400 ? 138.480 154.856 191.472 1.00 37.26  ?  389 ILE A CG2 1 
ATOM   1806 C CD1 . ILE A 1 400 ? 139.168 152.673 193.486 1.00 37.26  ?  389 ILE A CD1 1 
ATOM   1807 N N   . LEU A 1 401 ? 136.309 157.430 192.854 1.00 39.47  ?  390 LEU A N   1 
ATOM   1808 C CA  . LEU A 1 401 ? 135.429 158.348 192.154 1.00 39.47  ?  390 LEU A CA  1 
ATOM   1809 C C   . LEU A 1 401 ? 135.663 159.788 192.570 1.00 39.47  ?  390 LEU A C   1 
ATOM   1810 O O   . LEU A 1 401 ? 135.497 160.697 191.754 1.00 39.47  ?  390 LEU A O   1 
ATOM   1811 C CB  . LEU A 1 401 ? 133.985 157.949 192.399 1.00 39.47  ?  390 LEU A CB  1 
ATOM   1812 C CG  . LEU A 1 401 ? 133.413 157.080 191.301 1.00 39.47  ?  390 LEU A CG  1 
ATOM   1813 C CD1 . LEU A 1 401 ? 132.129 156.472 191.754 1.00 39.47  ?  390 LEU A CD1 1 
ATOM   1814 C CD2 . LEU A 1 401 ? 133.173 157.967 190.105 1.00 39.47  ?  390 LEU A CD2 1 
ATOM   1815 N N   . SER A 1 402 ? 136.040 160.017 193.827 1.00 42.76  ?  391 SER A N   1 
ATOM   1816 C CA  . SER A 1 402 ? 136.319 161.358 194.310 1.00 42.76  ?  391 SER A CA  1 
ATOM   1817 C C   . SER A 1 402 ? 137.557 161.967 193.687 1.00 42.76  ?  391 SER A C   1 
ATOM   1818 O O   . SER A 1 402 ? 137.604 163.187 193.524 1.00 42.76  ?  391 SER A O   1 
ATOM   1819 C CB  . SER A 1 402 ? 136.481 161.333 195.822 1.00 42.76  ?  391 SER A CB  1 
ATOM   1820 O OG  . SER A 1 402 ? 136.905 162.592 196.299 1.00 42.76  ?  391 SER A OG  1 
ATOM   1821 N N   . LEU A 1 403 ? 138.548 161.158 193.330 1.00 42.28  ?  392 LEU A N   1 
ATOM   1822 C CA  . LEU A 1 403 ? 139.722 161.673 192.638 1.00 42.28  ?  392 LEU A CA  1 
ATOM   1823 C C   . LEU A 1 403 ? 139.487 161.920 191.158 1.00 42.28  ?  392 LEU A C   1 
ATOM   1824 O O   . LEU A 1 403 ? 140.350 162.509 190.507 1.00 42.28  ?  392 LEU A O   1 
ATOM   1825 C CB  . LEU A 1 403 ? 140.889 160.707 192.784 1.00 42.28  ?  392 LEU A CB  1 
ATOM   1826 C CG  . LEU A 1 403 ? 141.577 160.679 194.133 1.00 42.28  ?  392 LEU A CG  1 
ATOM   1827 C CD1 . LEU A 1 403 ? 142.128 159.294 194.366 1.00 42.28  ?  392 LEU A CD1 1 
ATOM   1828 C CD2 . LEU A 1 403 ? 142.677 161.715 194.165 1.00 42.28  ?  392 LEU A CD2 1 
ATOM   1829 N N   . LEU A 1 404 ? 138.353 161.490 190.613 1.00 41.41  ?  393 LEU A N   1 
ATOM   1830 C CA  . LEU A 1 404 ? 138.108 161.559 189.179 1.00 41.41  ?  393 LEU A CA  1 
ATOM   1831 C C   . LEU A 1 404 ? 136.886 162.404 188.882 1.00 41.41  ?  393 LEU A C   1 
ATOM   1832 O O   . LEU A 1 404 ? 136.089 162.076 187.998 1.00 41.41  ?  393 LEU A O   1 
ATOM   1833 C CB  . LEU A 1 404 ? 137.925 160.167 188.574 1.00 41.41  ?  393 LEU A CB  1 
ATOM   1834 C CG  . LEU A 1 404 ? 139.136 159.296 188.250 1.00 41.41  ?  393 LEU A CG  1 
ATOM   1835 C CD1 . LEU A 1 404 ? 138.666 157.883 188.049 1.00 41.41  ?  393 LEU A CD1 1 
ATOM   1836 C CD2 . LEU A 1 404 ? 139.891 159.789 187.039 1.00 41.41  ?  393 LEU A CD2 1 
ATOM   1837 N N   . GLU A 1 405 ? 136.708 163.507 189.606 1.00 50.61  ?  394 GLU A N   1 
ATOM   1838 C CA  . GLU A 1 405 ? 135.596 164.394 189.308 1.00 50.61  ?  394 GLU A CA  1 
ATOM   1839 C C   . GLU A 1 405 ? 135.959 165.515 188.349 1.00 50.61  ?  394 GLU A C   1 
ATOM   1840 O O   . GLU A 1 405 ? 135.338 165.617 187.288 1.00 50.61  ?  394 GLU A O   1 
ATOM   1841 C CB  . GLU A 1 405 ? 135.013 164.989 190.593 1.00 50.61  ?  394 GLU A CB  1 
ATOM   1842 C CG  . GLU A 1 405 ? 134.831 163.979 191.705 1.00 50.61  ?  394 GLU A CG  1 
ATOM   1843 C CD  . GLU A 1 405 ? 134.018 164.531 192.862 1.00 50.61  ?  394 GLU A CD  1 
ATOM   1844 O OE1 . GLU A 1 405 ? 133.343 163.741 193.557 1.00 50.61  ?  394 GLU A OE1 1 
ATOM   1845 O OE2 . GLU A 1 405 ? 134.044 165.760 193.068 1.00 50.61  -1 394 GLU A OE2 1 
ATOM   1846 N N   . SER A 1 406 ? 136.945 166.344 188.676 1.00 53.08  ?  395 SER A N   1 
ATOM   1847 C CA  . SER A 1 406 ? 137.386 167.352 187.721 1.00 53.08  ?  395 SER A CA  1 
ATOM   1848 C C   . SER A 1 406 ? 138.266 166.744 186.642 1.00 53.08  ?  395 SER A C   1 
ATOM   1849 O O   . SER A 1 406 ? 138.147 167.099 185.465 1.00 53.08  ?  395 SER A O   1 
ATOM   1850 C CB  . SER A 1 406 ? 138.140 168.475 188.433 1.00 53.08  ?  395 SER A CB  1 
ATOM   1851 O OG  . SER A 1 406 ? 139.358 168.002 188.972 1.00 53.08  ?  395 SER A OG  1 
ATOM   1852 N N   . ASN A 1 407 ? 139.143 165.829 187.030 1.00 48.95  ?  396 ASN A N   1 
ATOM   1853 C CA  . ASN A 1 407 ? 139.956 165.058 186.110 1.00 48.95  ?  396 ASN A CA  1 
ATOM   1854 C C   . ASN A 1 407 ? 139.136 163.909 185.562 1.00 48.95  ?  396 ASN A C   1 
ATOM   1855 O O   . ASN A 1 407 ? 138.485 163.187 186.317 1.00 48.95  ?  396 ASN A O   1 
ATOM   1856 C CB  . ASN A 1 407 ? 141.180 164.501 186.817 1.00 48.95  ?  396 ASN A CB  1 
ATOM   1857 C CG  . ASN A 1 407 ? 142.171 165.553 187.150 1.00 48.95  ?  396 ASN A CG  1 
ATOM   1858 O OD1 . ASN A 1 407 ? 142.584 166.313 186.287 1.00 48.95  ?  396 ASN A OD1 1 
ATOM   1859 N ND2 . ASN A 1 407 ? 142.542 165.636 188.415 1.00 48.95  ?  396 ASN A ND2 1 
ATOM   1860 N N   . LYS A 1 408 ? 139.161 163.746 184.250 1.00 43.57  ?  397 LYS A N   1 
ATOM   1861 C CA  . LYS A 1 408 ? 138.511 162.607 183.630 1.00 43.57  ?  397 LYS A CA  1 
ATOM   1862 C C   . LYS A 1 408 ? 139.341 161.991 182.517 1.00 43.57  ?  397 LYS A C   1 
ATOM   1863 O O   . LYS A 1 408 ? 138.972 160.930 182.010 1.00 43.57  ?  397 LYS A O   1 
ATOM   1864 C CB  . LYS A 1 408 ? 137.133 163.013 183.099 1.00 43.57  ?  397 LYS A CB  1 
ATOM   1865 C CG  . LYS A 1 408 ? 136.046 163.050 184.166 1.00 43.57  ?  397 LYS A CG  1 
ATOM   1866 C CD  . LYS A 1 408 ? 134.788 163.720 183.669 1.00 43.57  ?  397 LYS A CD  1 
ATOM   1867 C CE  . LYS A 1 408 ? 133.628 163.489 184.625 1.00 43.57  ?  397 LYS A CE  1 
ATOM   1868 N NZ  . LYS A 1 408 ? 133.812 164.144 185.942 1.00 43.57  1  397 LYS A NZ  1 
ATOM   1869 N N   . ASP A 1 409 ? 140.452 162.605 182.139 1.00 39.05  ?  398 ASP A N   1 
ATOM   1870 C CA  . ASP A 1 409 ? 141.385 162.076 181.160 1.00 39.05  ?  398 ASP A CA  1 
ATOM   1871 C C   . ASP A 1 409 ? 142.505 161.295 181.835 1.00 39.05  ?  398 ASP A C   1 
ATOM   1872 O O   . ASP A 1 409 ? 143.445 160.855 181.171 1.00 39.05  ?  398 ASP A O   1 
ATOM   1873 C CB  . ASP A 1 409 ? 141.944 163.246 180.338 1.00 39.05  ?  398 ASP A CB  1 
ATOM   1874 C CG  . ASP A 1 409 ? 142.390 162.854 178.943 1.00 39.05  ?  398 ASP A CG  1 
ATOM   1875 O OD1 . ASP A 1 409 ? 143.453 162.231 178.755 1.00 39.05  ?  398 ASP A OD1 1 
ATOM   1876 O OD2 . ASP A 1 409 ? 141.687 163.252 177.999 1.00 39.05  -1 398 ASP A OD2 1 
ATOM   1877 N N   . LEU A 1 410 ? 142.408 161.096 183.139 1.00 26.84  ?  399 LEU A N   1 
ATOM   1878 C CA  . LEU A 1 410 ? 143.482 160.523 183.932 1.00 26.84  ?  399 LEU A CA  1 
ATOM   1879 C C   . LEU A 1 410 ? 143.331 159.010 183.971 1.00 26.84  ?  399 LEU A C   1 
ATOM   1880 O O   . LEU A 1 410 ? 142.242 158.507 184.251 1.00 26.84  ?  399 LEU A O   1 
ATOM   1881 C CB  . LEU A 1 410 ? 143.428 161.108 185.340 1.00 26.84  ?  399 LEU A CB  1 
ATOM   1882 C CG  . LEU A 1 410 ? 144.548 160.875 186.340 1.00 26.84  ?  399 LEU A CG  1 
ATOM   1883 C CD1 . LEU A 1 410 ? 145.582 161.929 186.169 1.00 26.84  ?  399 LEU A CD1 1 
ATOM   1884 C CD2 . LEU A 1 410 ? 144.003 160.888 187.742 1.00 26.84  ?  399 LEU A CD2 1 
ATOM   1885 N N   . LEU A 1 411 ? 144.408 158.283 183.675 1.00 18.19  ?  400 LEU A N   1 
ATOM   1886 C CA  . LEU A 1 411 ? 144.438 156.862 183.990 1.00 18.19  ?  400 LEU A CA  1 
ATOM   1887 C C   . LEU A 1 411 ? 144.771 156.698 185.461 1.00 18.19  ?  400 LEU A C   1 
ATOM   1888 O O   . LEU A 1 411 ? 145.698 157.327 185.960 1.00 18.19  ?  400 LEU A O   1 
ATOM   1889 C CB  . LEU A 1 411 ? 145.471 156.126 183.150 1.00 18.19  ?  400 LEU A CB  1 
ATOM   1890 C CG  . LEU A 1 411 ? 145.253 155.624 181.731 1.00 18.19  ?  400 LEU A CG  1 
ATOM   1891 C CD1 . LEU A 1 411 ? 146.357 154.644 181.425 1.00 18.19  ?  400 LEU A CD1 1 
ATOM   1892 C CD2 . LEU A 1 411 ? 143.914 154.981 181.530 1.00 18.19  ?  400 LEU A CD2 1 
ATOM   1893 N N   . LEU A 1 412 ? 144.024 155.859 186.164 1.00 18.26  ?  401 LEU A N   1 
ATOM   1894 C CA  . LEU A 1 412 ? 144.189 155.717 187.600 1.00 18.26  ?  401 LEU A CA  1 
ATOM   1895 C C   . LEU A 1 412 ? 144.200 154.245 187.965 1.00 18.26  ?  401 LEU A C   1 
ATOM   1896 O O   . LEU A 1 412 ? 143.211 153.548 187.738 1.00 18.26  ?  401 LEU A O   1 
ATOM   1897 C CB  . LEU A 1 412 ? 143.072 156.446 188.337 1.00 18.26  ?  401 LEU A CB  1 
ATOM   1898 C CG  . LEU A 1 412 ? 143.006 156.283 189.847 1.00 18.26  ?  401 LEU A CG  1 
ATOM   1899 C CD1 . LEU A 1 412 ? 143.970 157.170 190.550 1.00 18.26  ?  401 LEU A CD1 1 
ATOM   1900 C CD2 . LEU A 1 412 ? 141.622 156.553 190.286 1.00 18.26  ?  401 LEU A CD2 1 
ATOM   1901 N N   . THR A 1 413 ? 145.304 153.773 188.529 1.00 17.95  ?  402 THR A N   1 
ATOM   1902 C CA  . THR A 1 413 ? 145.455 152.378 188.916 1.00 17.95  ?  402 THR A CA  1 
ATOM   1903 C C   . THR A 1 413 ? 145.256 152.217 190.414 1.00 17.95  ?  402 THR A C   1 
ATOM   1904 O O   . THR A 1 413 ? 145.712 153.042 191.199 1.00 17.95  ?  402 THR A O   1 
ATOM   1905 C CB  . THR A 1 413 ? 146.825 151.854 188.509 1.00 17.95  ?  402 THR A CB  1 
ATOM   1906 O OG1 . THR A 1 413 ? 147.827 152.619 189.158 1.00 17.95  ?  402 THR A OG1 1 
ATOM   1907 C CG2 . THR A 1 413 ? 147.025 152.005 187.043 1.00 17.95  ?  402 THR A CG2 1 
ATOM   1908 N N   . SER A 1 414 ? 144.572 151.155 190.811 1.00 20.75  ?  403 SER A N   1 
ATOM   1909 C CA  . SER A 1 414 ? 144.119 151.024 192.186 1.00 20.75  ?  403 SER A CA  1 
ATOM   1910 C C   . SER A 1 414 ? 143.987 149.556 192.530 1.00 20.75  ?  403 SER A C   1 
ATOM   1911 O O   . SER A 1 414 ? 144.181 148.684 191.688 1.00 20.75  ?  403 SER A O   1 
ATOM   1912 C CB  . SER A 1 414 ? 142.789 151.729 192.396 1.00 20.75  ?  403 SER A CB  1 
ATOM   1913 O OG  . SER A 1 414 ? 141.824 151.233 191.490 1.00 20.75  ?  403 SER A OG  1 
ATOM   1914 N N   . SER A 1 415 ? 143.630 149.294 193.785 1.00 23.32  ?  404 SER A N   1 
ATOM   1915 C CA  . SER A 1 415 ? 143.437 147.944 194.294 1.00 23.32  ?  404 SER A CA  1 
ATOM   1916 C C   . SER A 1 415 ? 141.973 147.542 194.296 1.00 23.32  ?  404 SER A C   1 
ATOM   1917 O O   . SER A 1 415 ? 141.548 146.749 195.132 1.00 23.32  ?  404 SER A O   1 
ATOM   1918 C CB  . SER A 1 415 ? 144.021 147.818 195.694 1.00 23.32  ?  404 SER A CB  1 
ATOM   1919 O OG  . SER A 1 415 ? 145.431 147.855 195.662 1.00 23.32  ?  404 SER A OG  1 
ATOM   1920 N N   . TYR A 1 416 ? 141.209 148.056 193.339 1.00 27.15  ?  405 TYR A N   1 
ATOM   1921 C CA  . TYR A 1 416 ? 139.763 147.926 193.335 1.00 27.15  ?  405 TYR A CA  1 
ATOM   1922 C C   . TYR A 1 416 ? 139.318 146.513 193.005 1.00 27.15  ?  405 TYR A C   1 
ATOM   1923 O O   . TYR A 1 416 ? 138.293 146.057 193.512 1.00 27.15  ?  405 TYR A O   1 
ATOM   1924 C CB  . TYR A 1 416 ? 139.193 148.923 192.333 1.00 27.15  ?  405 TYR A CB  1 
ATOM   1925 C CG  . TYR A 1 416 ? 137.705 148.919 192.196 1.00 27.15  ?  405 TYR A CG  1 
ATOM   1926 C CD1 . TYR A 1 416 ? 136.915 149.618 193.080 1.00 27.15  ?  405 TYR A CD1 1 
ATOM   1927 C CD2 . TYR A 1 416 ? 137.088 148.237 191.163 1.00 27.15  ?  405 TYR A CD2 1 
ATOM   1928 C CE1 . TYR A 1 416 ? 135.563 149.616 192.957 1.00 27.15  ?  405 TYR A CE1 1 
ATOM   1929 C CE2 . TYR A 1 416 ? 135.735 148.225 191.041 1.00 27.15  ?  405 TYR A CE2 1 
ATOM   1930 C CZ  . TYR A 1 416 ? 134.980 148.920 191.938 1.00 27.15  ?  405 TYR A CZ  1 
ATOM   1931 O OH  . TYR A 1 416 ? 133.623 148.916 191.811 1.00 27.15  ?  405 TYR A OH  1 
ATOM   1932 N N   . LEU A 1 417 ? 140.053 145.813 192.154 1.00 27.11  ?  406 LEU A N   1 
ATOM   1933 C CA  . LEU A 1 417 ? 139.698 144.457 191.774 1.00 27.11  ?  406 LEU A CA  1 
ATOM   1934 C C   . LEU A 1 417 ? 140.458 143.410 192.557 1.00 27.11  ?  406 LEU A C   1 
ATOM   1935 O O   . LEU A 1 417 ? 140.182 142.220 192.398 1.00 27.11  ?  406 LEU A O   1 
ATOM   1936 C CB  . LEU A 1 417 ? 139.969 144.218 190.297 1.00 27.11  ?  406 LEU A CB  1 
ATOM   1937 C CG  . LEU A 1 417 ? 139.090 144.780 189.199 1.00 27.11  ?  406 LEU A CG  1 
ATOM   1938 C CD1 . LEU A 1 417 ? 139.456 144.091 187.918 1.00 27.11  ?  406 LEU A CD1 1 
ATOM   1939 C CD2 . LEU A 1 417 ? 137.646 144.571 189.515 1.00 27.11  ?  406 LEU A CD2 1 
ATOM   1940 N N   . SER A 1 418 ? 141.412 143.814 193.380 1.00 36.61  ?  407 SER A N   1 
ATOM   1941 C CA  . SER A 1 418 ? 142.232 142.876 194.121 1.00 36.61  ?  407 SER A CA  1 
ATOM   1942 C C   . SER A 1 418 ? 141.630 142.479 195.452 1.00 36.61  ?  407 SER A C   1 
ATOM   1943 O O   . SER A 1 418 ? 142.295 141.779 196.219 1.00 36.61  ?  407 SER A O   1 
ATOM   1944 C CB  . SER A 1 418 ? 143.606 143.472 194.364 1.00 36.61  ?  407 SER A CB  1 
ATOM   1945 O OG  . SER A 1 418 ? 143.506 144.592 195.210 1.00 36.61  ?  407 SER A OG  1 
ATOM   1946 N N   . ASP A 1 419 ? 140.408 142.914 195.749 1.00 53.99  ?  408 ASP A N   1 
ATOM   1947 C CA  . ASP A 1 419 ? 139.753 142.594 197.008 1.00 53.99  ?  408 ASP A CA  1 
ATOM   1948 C C   . ASP A 1 419 ? 139.418 141.108 197.060 1.00 53.99  ?  408 ASP A C   1 
ATOM   1949 O O   . ASP A 1 419 ? 139.965 140.368 197.883 1.00 53.99  ?  408 ASP A O   1 
ATOM   1950 C CB  . ASP A 1 419 ? 138.481 143.435 197.169 1.00 53.99  ?  408 ASP A CB  1 
ATOM   1951 C CG  . ASP A 1 419 ? 137.992 143.516 198.613 1.00 53.99  ?  408 ASP A CG  1 
ATOM   1952 O OD1 . ASP A 1 419 ? 138.391 142.680 199.447 1.00 53.99  ?  408 ASP A OD1 1 
ATOM   1953 O OD2 . ASP A 1 419 ? 137.189 144.424 198.912 1.00 53.99  -1 408 ASP A OD2 1 
ATOM   1954 N N   . SER A 1 420 ? 138.534 140.670 196.175 1.00 63.03  ?  409 SER A N   1 
ATOM   1955 C CA  . SER A 1 420 ? 138.025 139.311 196.200 1.00 63.03  ?  409 SER A CA  1 
ATOM   1956 C C   . SER A 1 420 ? 137.518 138.986 194.799 1.00 63.03  ?  409 SER A C   1 
ATOM   1957 O O   . SER A 1 420 ? 137.890 139.652 193.827 1.00 63.03  ?  409 SER A O   1 
ATOM   1958 C CB  . SER A 1 420 ? 136.953 139.138 197.289 1.00 63.03  ?  409 SER A CB  1 
ATOM   1959 O OG  . SER A 1 420 ? 136.414 137.826 197.256 1.00 63.03  ?  409 SER A OG  1 
ATOM   1960 N N   . GLY A 1 421 ? 136.662 137.974 194.699 1.00 67.93  ?  410 GLY A N   1 
ATOM   1961 C CA  . GLY A 1 421 ? 136.370 137.329 193.439 1.00 67.93  ?  410 GLY A CA  1 
ATOM   1962 C C   . GLY A 1 421 ? 136.415 135.831 193.619 1.00 67.93  ?  410 GLY A C   1 
ATOM   1963 O O   . GLY A 1 421 ? 136.607 135.062 192.670 1.00 67.93  ?  410 GLY A O   1 
ATOM   1964 N N   . SER A 1 422 ? 136.241 135.429 194.882 1.00 70.39  ?  411 SER A N   1 
ATOM   1965 C CA  . SER A 1 422 ? 135.949 134.040 195.222 1.00 70.39  ?  411 SER A CA  1 
ATOM   1966 C C   . SER A 1 422 ? 134.702 133.550 194.501 1.00 70.39  ?  411 SER A C   1 
ATOM   1967 O O   . SER A 1 422 ? 134.598 132.369 194.150 1.00 70.39  ?  411 SER A O   1 
ATOM   1968 C CB  . SER A 1 422 ? 135.760 133.915 196.731 1.00 70.39  ?  411 SER A CB  1 
ATOM   1969 O OG  . SER A 1 422 ? 134.540 134.526 197.119 1.00 70.39  ?  411 SER A OG  1 
ATOM   1970 N N   . THR A 1 423 ? 133.739 134.438 194.300 1.00 63.83  ?  412 THR A N   1 
ATOM   1971 C CA  . THR A 1 423 ? 132.595 134.208 193.441 1.00 63.83  ?  412 THR A CA  1 
ATOM   1972 C C   . THR A 1 423 ? 132.660 135.146 192.241 1.00 63.83  ?  412 THR A C   1 
ATOM   1973 O O   . THR A 1 423 ? 133.091 136.295 192.352 1.00 63.83  ?  412 THR A O   1 
ATOM   1974 C CB  . THR A 1 423 ? 131.297 134.403 194.225 1.00 63.83  ?  412 THR A CB  1 
ATOM   1975 O OG1 . THR A 1 423 ? 131.300 135.694 194.848 1.00 63.83  ?  412 THR A OG1 1 
ATOM   1976 C CG2 . THR A 1 423 ? 131.160 133.327 195.287 1.00 63.83  ?  412 THR A CG2 1 
ATOM   1977 N N   . GLY A 1 424 ? 132.245 134.632 191.082 1.00 56.55  ?  413 GLY A N   1 
ATOM   1978 C CA  . GLY A 1 424 ? 132.384 135.367 189.838 1.00 56.55  ?  413 GLY A CA  1 
ATOM   1979 C C   . GLY A 1 424 ? 131.396 136.496 189.664 1.00 56.55  ?  413 GLY A C   1 
ATOM   1980 O O   . GLY A 1 424 ? 131.726 137.501 189.025 1.00 56.55  ?  413 GLY A O   1 
ATOM   1981 N N   . GLU A 1 425 ? 130.200 136.368 190.241 1.00 56.31  ?  414 GLU A N   1 
ATOM   1982 C CA  . GLU A 1 425 ? 129.228 137.454 190.186 1.00 56.31  ?  414 GLU A CA  1 
ATOM   1983 C C   . GLU A 1 425 ? 129.680 138.639 191.030 1.00 56.31  ?  414 GLU A C   1 
ATOM   1984 O O   . GLU A 1 425 ? 129.236 139.765 190.798 1.00 56.31  ?  414 GLU A O   1 
ATOM   1985 C CB  . GLU A 1 425 ? 127.849 136.956 190.635 1.00 56.31  ?  414 GLU A CB  1 
ATOM   1986 C CG  . GLU A 1 425 ? 127.716 136.755 192.137 1.00 56.31  ?  414 GLU A CG  1 
ATOM   1987 C CD  . GLU A 1 425 ? 128.065 135.353 192.583 1.00 56.31  ?  414 GLU A CD  1 
ATOM   1988 O OE1 . GLU A 1 425 ? 128.458 134.528 191.736 1.00 56.31  ?  414 GLU A OE1 1 
ATOM   1989 O OE2 . GLU A 1 425 ? 127.966 135.082 193.796 1.00 56.31  -1 414 GLU A OE2 1 
ATOM   1990 N N   . HIS A 1 426 ? 130.598 138.418 191.973 1.00 52.49  ?  415 HIS A N   1 
ATOM   1991 C CA  . HIS A 1 426 ? 131.202 139.538 192.677 1.00 52.49  ?  415 HIS A CA  1 
ATOM   1992 C C   . HIS A 1 426 ? 132.106 140.352 191.757 1.00 52.49  ?  415 HIS A C   1 
ATOM   1993 O O   . HIS A 1 426 ? 132.061 141.588 191.772 1.00 52.49  ?  415 HIS A O   1 
ATOM   1994 C CB  . HIS A 1 426 ? 131.976 139.039 193.892 1.00 52.49  ?  415 HIS A CB  1 
ATOM   1995 C CG  . HIS A 1 426 ? 132.325 140.124 194.856 1.00 52.49  ?  415 HIS A CG  1 
ATOM   1996 N ND1 . HIS A 1 426 ? 133.511 140.146 195.554 1.00 52.49  ?  415 HIS A ND1 1 
ATOM   1997 C CD2 . HIS A 1 426 ? 131.650 141.237 195.222 1.00 52.49  ?  415 HIS A CD2 1 
ATOM   1998 C CE1 . HIS A 1 426 ? 133.551 141.226 196.313 1.00 52.49  ?  415 HIS A CE1 1 
ATOM   1999 N NE2 . HIS A 1 426 ? 132.432 141.903 196.131 1.00 52.49  ?  415 HIS A NE2 1 
ATOM   2000 N N   . THR A 1 427 ? 132.917 139.679 190.938 1.00 42.53  ?  416 THR A N   1 
ATOM   2001 C CA  . THR A 1 427 ? 133.749 140.390 189.970 1.00 42.53  ?  416 THR A CA  1 
ATOM   2002 C C   . THR A 1 427 ? 132.899 141.063 188.904 1.00 42.53  ?  416 THR A C   1 
ATOM   2003 O O   . THR A 1 427 ? 133.207 142.181 188.475 1.00 42.53  ?  416 THR A O   1 
ATOM   2004 C CB  . THR A 1 427 ? 134.748 139.430 189.335 1.00 42.53  ?  416 THR A CB  1 
ATOM   2005 O OG1 . THR A 1 427 ? 135.337 138.624 190.356 1.00 42.53  ?  416 THR A OG1 1 
ATOM   2006 C CG2 . THR A 1 427 ? 135.845 140.189 188.637 1.00 42.53  ?  416 THR A CG2 1 
ATOM   2007 N N   . LYS A 1 428 ? 131.819 140.402 188.487 1.00 37.20  ?  417 LYS A N   1 
ATOM   2008 C CA  . LYS A 1 428 ? 130.856 141.006 187.575 1.00 37.20  ?  417 LYS A CA  1 
ATOM   2009 C C   . LYS A 1 428 ? 130.235 142.262 188.165 1.00 37.20  ?  417 LYS A C   1 
ATOM   2010 O O   . LYS A 1 428 ? 130.086 143.276 187.471 1.00 37.20  ?  417 LYS A O   1 
ATOM   2011 C CB  . LYS A 1 428 ? 129.781 139.979 187.237 1.00 37.20  ?  417 LYS A CB  1 
ATOM   2012 C CG  . LYS A 1 428 ? 128.551 140.525 186.580 1.00 37.20  ?  417 LYS A CG  1 
ATOM   2013 C CD  . LYS A 1 428 ? 127.731 139.403 185.990 1.00 37.20  ?  417 LYS A CD  1 
ATOM   2014 C CE  . LYS A 1 428 ? 126.510 139.943 185.281 1.00 37.20  ?  417 LYS A CE  1 
ATOM   2015 N NZ  . LYS A 1 428 ? 125.791 138.872 184.562 1.00 37.20  1  417 LYS A NZ  1 
ATOM   2016 N N   . SER A 1 429 ? 129.902 142.222 189.456 1.00 38.20  ?  418 SER A N   1 
ATOM   2017 C CA  . SER A 1 429 ? 129.345 143.381 190.136 1.00 38.20  ?  418 SER A CA  1 
ATOM   2018 C C   . SER A 1 429 ? 130.344 144.516 190.221 1.00 38.20  ?  418 SER A C   1 
ATOM   2019 O O   . SER A 1 429 ? 129.974 145.676 190.045 1.00 38.20  ?  418 SER A O   1 
ATOM   2020 C CB  . SER A 1 429 ? 128.904 142.999 191.537 1.00 38.20  ?  418 SER A CB  1 
ATOM   2021 O OG  . SER A 1 429 ? 128.896 144.148 192.363 1.00 38.20  ?  418 SER A OG  1 
ATOM   2022 N N   . LEU A 1 430 ? 131.613 144.197 190.465 1.00 31.85  ?  419 LEU A N   1 
ATOM   2023 C CA  . LEU A 1 430 ? 132.639 145.226 190.550 1.00 31.85  ?  419 LEU A CA  1 
ATOM   2024 C C   . LEU A 1 430 ? 132.843 145.914 189.211 1.00 31.85  ?  419 LEU A C   1 
ATOM   2025 O O   . LEU A 1 430 ? 132.878 147.149 189.137 1.00 31.85  ?  419 LEU A O   1 
ATOM   2026 C CB  . LEU A 1 430 ? 133.944 144.610 191.037 1.00 31.85  ?  419 LEU A CB  1 
ATOM   2027 C CG  . LEU A 1 430 ? 134.048 144.220 192.506 1.00 31.85  ?  419 LEU A CG  1 
ATOM   2028 C CD1 . LEU A 1 430 ? 135.390 143.613 192.768 1.00 31.85  ?  419 LEU A CD1 1 
ATOM   2029 C CD2 . LEU A 1 430 ? 133.833 145.421 193.381 1.00 31.85  ?  419 LEU A CD2 1 
ATOM   2030 N N   . VAL A 1 431 ? 132.931 145.126 188.135 1.00 27.18  ?  420 VAL A N   1 
ATOM   2031 C CA  . VAL A 1 431 ? 133.182 145.681 186.807 1.00 27.18  ?  420 VAL A CA  1 
ATOM   2032 C C   . VAL A 1 431 ? 131.998 146.514 186.328 1.00 27.18  ?  420 VAL A C   1 
ATOM   2033 O O   . VAL A 1 431 ? 132.167 147.660 185.882 1.00 27.18  ?  420 VAL A O   1 
ATOM   2034 C CB  . VAL A 1 431 ? 133.524 144.552 185.819 1.00 27.18  ?  420 VAL A CB  1 
ATOM   2035 C CG1 . VAL A 1 431 ? 133.624 145.085 184.417 1.00 27.18  ?  420 VAL A CG1 1 
ATOM   2036 C CG2 . VAL A 1 431 ? 134.816 143.895 186.197 1.00 27.18  ?  420 VAL A CG2 1 
ATOM   2037 N N   . THR A 1 432 ? 130.778 145.978 186.451 1.00 33.02  ?  421 THR A N   1 
ATOM   2038 C CA  . THR A 1 432 ? 129.613 146.718 185.982 1.00 33.02  ?  421 THR A CA  1 
ATOM   2039 C C   . THR A 1 432 ? 129.292 147.908 186.874 1.00 33.02  ?  421 THR A C   1 
ATOM   2040 O O   . THR A 1 432 ? 128.818 148.929 186.370 1.00 33.02  ?  421 THR A O   1 
ATOM   2041 C CB  . THR A 1 432 ? 128.401 145.805 185.879 1.00 33.02  ?  421 THR A CB  1 
ATOM   2042 O OG1 . THR A 1 432 ? 128.167 145.188 187.145 1.00 33.02  ?  421 THR A OG1 1 
ATOM   2043 C CG2 . THR A 1 432 ? 128.636 144.740 184.845 1.00 33.02  ?  421 THR A CG2 1 
ATOM   2044 N N   . GLN A 1 433 ? 129.576 147.827 188.177 1.00 32.94  ?  422 GLN A N   1 
ATOM   2045 C CA  . GLN A 1 433 ? 129.353 148.967 189.050 1.00 32.94  ?  422 GLN A CA  1 
ATOM   2046 C C   . GLN A 1 433 ? 130.332 150.089 188.764 1.00 32.94  ?  422 GLN A C   1 
ATOM   2047 O O   . GLN A 1 433 ? 129.939 151.256 188.789 1.00 32.94  ?  422 GLN A O   1 
ATOM   2048 C CB  . GLN A 1 433 ? 129.456 148.544 190.508 1.00 32.94  ?  422 GLN A CB  1 
ATOM   2049 C CG  . GLN A 1 433 ? 128.146 148.147 191.135 1.00 32.94  ?  422 GLN A CG  1 
ATOM   2050 C CD  . GLN A 1 433 ? 128.344 147.511 192.492 1.00 32.94  ?  422 GLN A CD  1 
ATOM   2051 O OE1 . GLN A 1 433 ? 129.249 147.885 193.235 1.00 32.94  ?  422 GLN A OE1 1 
ATOM   2052 N NE2 . GLN A 1 433 ? 127.513 146.529 192.814 1.00 32.94  ?  422 GLN A NE2 1 
ATOM   2053 N N   . TYR A 1 434 ? 131.601 149.766 188.467 1.00 28.08  ?  423 TYR A N   1 
ATOM   2054 C CA  . TYR A 1 434 ? 132.555 150.801 188.067 1.00 28.08  ?  423 TYR A CA  1 
ATOM   2055 C C   . TYR A 1 434 ? 132.136 151.465 186.762 1.00 28.08  ?  423 TYR A C   1 
ATOM   2056 O O   . TYR A 1 434 ? 132.132 152.699 186.652 1.00 28.08  ?  423 TYR A O   1 
ATOM   2057 C CB  . TYR A 1 434 ? 133.961 150.212 187.937 1.00 28.08  ?  423 TYR A CB  1 
ATOM   2058 C CG  . TYR A 1 434 ? 135.042 151.261 187.842 1.00 28.08  ?  423 TYR A CG  1 
ATOM   2059 C CD1 . TYR A 1 434 ? 135.422 151.792 186.620 1.00 28.08  ?  423 TYR A CD1 1 
ATOM   2060 C CD2 . TYR A 1 434 ? 135.673 151.733 188.974 1.00 28.08  ?  423 TYR A CD2 1 
ATOM   2061 C CE1 . TYR A 1 434 ? 136.371 152.763 186.532 1.00 28.08  ?  423 TYR A CE1 1 
ATOM   2062 C CE2 . TYR A 1 434 ? 136.644 152.697 188.887 1.00 28.08  ?  423 TYR A CE2 1 
ATOM   2063 C CZ  . TYR A 1 434 ? 136.984 153.208 187.660 1.00 28.08  ?  423 TYR A CZ  1 
ATOM   2064 O OH  . TYR A 1 434 ? 137.954 154.166 187.560 1.00 28.08  ?  423 TYR A OH  1 
ATOM   2065 N N   . LEU A 1 435 ? 131.771 150.661 185.764 1.00 29.80  ?  424 LEU A N   1 
ATOM   2066 C CA  . LEU A 1 435 ? 131.412 151.229 184.474 1.00 29.80  ?  424 LEU A CA  1 
ATOM   2067 C C   . LEU A 1 435 ? 130.100 151.997 184.520 1.00 29.80  ?  424 LEU A C   1 
ATOM   2068 O O   . LEU A 1 435 ? 129.926 152.941 183.747 1.00 29.80  ?  424 LEU A O   1 
ATOM   2069 C CB  . LEU A 1 435 ? 131.346 150.126 183.427 1.00 29.80  ?  424 LEU A CB  1 
ATOM   2070 C CG  . LEU A 1 435 ? 132.715 149.583 183.055 1.00 29.80  ?  424 LEU A CG  1 
ATOM   2071 C CD1 . LEU A 1 435 ? 132.609 148.388 182.174 1.00 29.80  ?  424 LEU A CD1 1 
ATOM   2072 C CD2 . LEU A 1 435 ? 133.518 150.652 182.395 1.00 29.80  ?  424 LEU A CD2 1 
ATOM   2073 N N   . ASN A 1 436 ? 129.191 151.638 185.423 1.00 41.83  ?  425 ASN A N   1 
ATOM   2074 C CA  . ASN A 1 436 ? 127.962 152.401 185.581 1.00 41.83  ?  425 ASN A CA  1 
ATOM   2075 C C   . ASN A 1 436 ? 128.215 153.685 186.346 1.00 41.83  ?  425 ASN A C   1 
ATOM   2076 O O   . ASN A 1 436 ? 127.635 154.726 186.032 1.00 41.83  ?  425 ASN A O   1 
ATOM   2077 C CB  . ASN A 1 436 ? 126.918 151.551 186.294 1.00 41.83  ?  425 ASN A CB  1 
ATOM   2078 C CG  . ASN A 1 436 ? 125.517 152.095 186.147 1.00 41.83  ?  425 ASN A CG  1 
ATOM   2079 O OD1 . ASN A 1 436 ? 125.244 152.934 185.288 1.00 41.83  ?  425 ASN A OD1 1 
ATOM   2080 N ND2 . ASN A 1 436 ? 124.614 151.609 186.992 1.00 41.83  ?  425 ASN A ND2 1 
ATOM   2081 N N   . ALA A 1 437 ? 129.085 153.637 187.351 1.00 31.08  ?  426 ALA A N   1 
ATOM   2082 C CA  . ALA A 1 437 ? 129.319 154.803 188.181 1.00 31.08  ?  426 ALA A CA  1 
ATOM   2083 C C   . ALA A 1 437 ? 130.147 155.864 187.482 1.00 31.08  ?  426 ALA A C   1 
ATOM   2084 O O   . ALA A 1 437 ? 130.061 157.035 187.853 1.00 31.08  ?  426 ALA A O   1 
ATOM   2085 C CB  . ALA A 1 437 ? 129.995 154.381 189.478 1.00 31.08  ?  426 ALA A CB  1 
ATOM   2086 N N   . THR A 1 438 ? 130.962 155.491 186.502 1.00 32.37  ?  427 THR A N   1 
ATOM   2087 C CA  . THR A 1 438 ? 131.714 156.524 185.798 1.00 32.37  ?  427 THR A CA  1 
ATOM   2088 C C   . THR A 1 438 ? 131.134 156.859 184.431 1.00 32.37  ?  427 THR A C   1 
ATOM   2089 O O   . THR A 1 438 ? 131.626 157.772 183.765 1.00 32.37  ?  427 THR A O   1 
ATOM   2090 C CB  . THR A 1 438 ? 133.173 156.114 185.654 1.00 32.37  ?  427 THR A CB  1 
ATOM   2091 O OG1 . THR A 1 438 ? 133.281 155.100 184.657 1.00 32.37  ?  427 THR A OG1 1 
ATOM   2092 C CG2 . THR A 1 438 ? 133.703 155.601 186.965 1.00 32.37  ?  427 THR A CG2 1 
ATOM   2093 N N   . GLY A 1 439 ? 130.114 156.143 183.981 1.00 32.44  ?  428 GLY A N   1 
ATOM   2094 C CA  . GLY A 1 439 ? 129.449 156.527 182.755 1.00 32.44  ?  428 GLY A CA  1 
ATOM   2095 C C   . GLY A 1 439 ? 130.142 156.036 181.505 1.00 32.44  ?  428 GLY A C   1 
ATOM   2096 O O   . GLY A 1 439 ? 130.094 156.705 180.471 1.00 32.44  ?  428 GLY A O   1 
ATOM   2097 N N   . ASN A 1 440 ? 130.792 154.874 181.613 1.00 30.79  ?  429 ASN A N   1 
ATOM   2098 C CA  . ASN A 1 440 ? 131.479 154.193 180.512 1.00 30.79  ?  429 ASN A CA  1 
ATOM   2099 C C   . ASN A 1 440 ? 132.557 155.061 179.876 1.00 30.79  ?  429 ASN A C   1 
ATOM   2100 O O   . ASN A 1 440 ? 132.696 155.126 178.659 1.00 30.79  ?  429 ASN A O   1 
ATOM   2101 C CB  . ASN A 1 440 ? 130.492 153.689 179.464 1.00 30.79  ?  429 ASN A CB  1 
ATOM   2102 C CG  . ASN A 1 440 ? 129.990 152.308 179.772 1.00 30.79  ?  429 ASN A CG  1 
ATOM   2103 O OD1 . ASN A 1 440 ? 130.578 151.317 179.353 1.00 30.79  ?  429 ASN A OD1 1 
ATOM   2104 N ND2 . ASN A 1 440 ? 128.898 152.230 180.505 1.00 30.79  ?  429 ASN A ND2 1 
ATOM   2105 N N   . ARG A 1 441 ? 133.327 155.729 180.713 1.00 30.22  ?  430 ARG A N   1 
ATOM   2106 C CA  . ARG A 1 441 ? 134.484 156.491 180.287 1.00 30.22  ?  430 ARG A CA  1 
ATOM   2107 C C   . ARG A 1 441 ? 135.664 155.541 180.121 1.00 30.22  ?  430 ARG A C   1 
ATOM   2108 O O   . ARG A 1 441 ? 135.580 154.359 180.444 1.00 30.22  ?  430 ARG A O   1 
ATOM   2109 C CB  . ARG A 1 441 ? 134.773 157.592 181.302 1.00 30.22  ?  430 ARG A CB  1 
ATOM   2110 C CG  . ARG A 1 441 ? 135.230 158.885 180.695 1.00 30.22  ?  430 ARG A CG  1 
ATOM   2111 C CD  . ARG A 1 441 ? 135.179 160.027 181.690 1.00 30.22  ?  430 ARG A CD  1 
ATOM   2112 N NE  . ARG A 1 441 ? 133.821 160.492 181.925 1.00 30.22  ?  430 ARG A NE  1 
ATOM   2113 C CZ  . ARG A 1 441 ? 133.175 160.368 183.078 1.00 30.22  ?  430 ARG A CZ  1 
ATOM   2114 N NH1 . ARG A 1 441 ? 133.763 159.789 184.117 1.00 30.22  1  430 ARG A NH1 1 
ATOM   2115 N NH2 . ARG A 1 441 ? 131.938 160.822 183.195 1.00 30.22  ?  430 ARG A NH2 1 
ATOM   2116 N N   . TRP A 1 442 ? 136.768 156.049 179.587 1.00 13.98  ?  431 TRP A N   1 
ATOM   2117 C CA  . TRP A 1 442 ? 137.949 155.216 179.394 1.00 13.98  ?  431 TRP A CA  1 
ATOM   2118 C C   . TRP A 1 442 ? 138.660 155.017 180.727 1.00 13.98  ?  431 TRP A C   1 
ATOM   2119 O O   . TRP A 1 442 ? 139.040 155.983 181.389 1.00 13.98  ?  431 TRP A O   1 
ATOM   2120 C CB  . TRP A 1 442 ? 138.891 155.827 178.367 1.00 13.98  ?  431 TRP A CB  1 
ATOM   2121 C CG  . TRP A 1 442 ? 139.947 154.875 177.936 1.00 13.98  ?  431 TRP A CG  1 
ATOM   2122 C CD1 . TRP A 1 442 ? 141.208 154.790 178.410 1.00 13.98  ?  431 TRP A CD1 1 
ATOM   2123 C CD2 . TRP A 1 442 ? 139.827 153.864 176.945 1.00 13.98  ?  431 TRP A CD2 1 
ATOM   2124 N NE1 . TRP A 1 442 ? 141.882 153.800 177.783 1.00 13.98  ?  431 TRP A NE1 1 
ATOM   2125 C CE2 . TRP A 1 442 ? 141.054 153.212 176.874 1.00 13.98  ?  431 TRP A CE2 1 
ATOM   2126 C CE3 . TRP A 1 442 ? 138.797 153.455 176.100 1.00 13.98  ?  431 TRP A CE3 1 
ATOM   2127 C CZ2 . TRP A 1 442 ? 141.286 152.179 176.001 1.00 13.98  ?  431 TRP A CZ2 1 
ATOM   2128 C CZ3 . TRP A 1 442 ? 139.033 152.422 175.236 1.00 13.98  ?  431 TRP A CZ3 1 
ATOM   2129 C CH2 . TRP A 1 442 ? 140.265 151.799 175.188 1.00 13.98  ?  431 TRP A CH2 1 
ATOM   2130 N N   . CYS A 1 443 ? 138.863 153.767 181.110 1.00 12.79  ?  432 CYS A N   1 
ATOM   2131 C CA  . CYS A 1 443 ? 139.501 153.415 182.361 1.00 12.79  ?  432 CYS A CA  1 
ATOM   2132 C C   . CYS A 1 443 ? 140.713 152.530 182.102 1.00 12.79  ?  432 CYS A C   1 
ATOM   2133 O O   . CYS A 1 443 ? 141.030 152.180 180.975 1.00 12.79  ?  432 CYS A O   1 
ATOM   2134 C CB  . CYS A 1 443 ? 138.510 152.718 183.286 1.00 12.79  ?  432 CYS A CB  1 
ATOM   2135 S SG  . CYS A 1 443 ? 137.832 151.257 182.617 1.00 12.79  ?  432 CYS A SG  1 
ATOM   2136 N N   . SER A 1 444 ? 141.401 152.188 183.177 1.00 13.19  ?  433 SER A N   1 
ATOM   2137 C CA  . SER A 1 444 ? 142.489 151.232 183.167 1.00 13.19  ?  433 SER A CA  1 
ATOM   2138 C C   . SER A 1 444 ? 142.086 150.041 184.012 1.00 13.19  ?  433 SER A C   1 
ATOM   2139 O O   . SER A 1 444 ? 141.309 150.179 184.951 1.00 13.19  ?  433 SER A O   1 
ATOM   2140 C CB  . SER A 1 444 ? 143.767 151.852 183.698 1.00 13.19  ?  433 SER A CB  1 
ATOM   2141 O OG  . SER A 1 444 ? 143.865 151.715 185.089 1.00 13.19  ?  433 SER A OG  1 
ATOM   2142 N N   . TRP A 1 445 ? 142.600 148.873 183.678 1.00 11.41  ?  434 TRP A N   1 
ATOM   2143 C CA  . TRP A 1 445 ? 142.283 147.648 184.389 1.00 11.41  ?  434 TRP A CA  1 
ATOM   2144 C C   . TRP A 1 445 ? 143.574 147.009 184.854 1.00 11.41  ?  434 TRP A C   1 
ATOM   2145 O O   . TRP A 1 445 ? 144.460 146.743 184.048 1.00 11.41  ?  434 TRP A O   1 
ATOM   2146 C CB  . TRP A 1 445 ? 141.505 146.687 183.499 1.00 11.41  ?  434 TRP A CB  1 
ATOM   2147 C CG  . TRP A 1 445 ? 140.179 147.194 183.100 1.00 11.41  ?  434 TRP A CG  1 
ATOM   2148 C CD1 . TRP A 1 445 ? 139.821 147.658 181.884 1.00 11.41  ?  434 TRP A CD1 1 
ATOM   2149 C CD2 . TRP A 1 445 ? 139.025 147.297 183.925 1.00 11.41  ?  434 TRP A CD2 1 
ATOM   2150 N NE1 . TRP A 1 445 ? 138.513 148.035 181.891 1.00 11.41  ?  434 TRP A NE1 1 
ATOM   2151 C CE2 . TRP A 1 445 ? 138.003 147.832 183.141 1.00 11.41  ?  434 TRP A CE2 1 
ATOM   2152 C CE3 . TRP A 1 445 ? 138.759 146.989 185.258 1.00 11.41  ?  434 TRP A CE3 1 
ATOM   2153 C CZ2 . TRP A 1 445 ? 136.729 148.050 183.633 1.00 11.41  ?  434 TRP A CZ2 1 
ATOM   2154 C CZ3 . TRP A 1 445 ? 137.499 147.223 185.746 1.00 11.41  ?  434 TRP A CZ3 1 
ATOM   2155 C CH2 . TRP A 1 445 ? 136.502 147.752 184.940 1.00 11.41  ?  434 TRP A CH2 1 
ATOM   2156 N N   . SER A 1 446 ? 143.675 146.768 186.148 1.00 15.41  ?  435 SER A N   1 
ATOM   2157 C CA  . SER A 1 446 ? 144.844 146.141 186.731 1.00 15.41  ?  435 SER A CA  1 
ATOM   2158 C C   . SER A 1 446 ? 144.415 145.547 188.051 1.00 15.41  ?  435 SER A C   1 
ATOM   2159 O O   . SER A 1 446 ? 143.259 145.659 188.449 1.00 15.41  ?  435 SER A O   1 
ATOM   2160 C CB  . SER A 1 446 ? 145.978 147.135 186.920 1.00 15.41  ?  435 SER A CB  1 
ATOM   2161 O OG  . SER A 1 446 ? 145.545 148.245 187.657 1.00 15.41  ?  435 SER A OG  1 
ATOM   2162 N N   . LEU A 1 447 ? 145.354 144.906 188.730 1.00 22.53  ?  436 LEU A N   1 
ATOM   2163 C CA  . LEU A 1 447 ? 145.081 144.458 190.083 1.00 22.53  ?  436 LEU A CA  1 
ATOM   2164 C C   . LEU A 1 447 ? 145.781 145.288 191.140 1.00 22.53  ?  436 LEU A C   1 
ATOM   2165 O O   . LEU A 1 447 ? 145.405 145.220 192.305 1.00 22.53  ?  436 LEU A O   1 
ATOM   2166 C CB  . LEU A 1 447 ? 145.466 142.988 190.254 1.00 22.53  ?  436 LEU A CB  1 
ATOM   2167 C CG  . LEU A 1 447 ? 144.548 141.945 189.615 1.00 22.53  ?  436 LEU A CG  1 
ATOM   2168 C CD1 . LEU A 1 447 ? 144.690 140.644 190.336 1.00 22.53  ?  436 LEU A CD1 1 
ATOM   2169 C CD2 . LEU A 1 447 ? 143.108 142.353 189.577 1.00 22.53  ?  436 LEU A CD2 1 
ATOM   2170 N N   . SER A 1 448 ? 146.773 146.076 190.774 1.00 19.55  ?  437 SER A N   1 
ATOM   2171 C CA  . SER A 1 448 ? 147.500 146.838 191.763 1.00 19.55  ?  437 SER A CA  1 
ATOM   2172 C C   . SER A 1 448 ? 147.999 148.117 191.127 1.00 19.55  ?  437 SER A C   1 
ATOM   2173 O O   . SER A 1 448 ? 147.832 148.347 189.934 1.00 19.55  ?  437 SER A O   1 
ATOM   2174 C CB  . SER A 1 448 ? 148.659 146.029 192.331 1.00 19.55  ?  437 SER A CB  1 
ATOM   2175 O OG  . SER A 1 448 ? 149.315 146.745 193.356 1.00 19.55  ?  437 SER A OG  1 
ATOM   2176 N N   . GLN A 1 449 ? 148.625 148.948 191.938 1.00 19.28  ?  438 GLN A N   1 
ATOM   2177 C CA  . GLN A 1 449 ? 149.387 150.052 191.402 1.00 19.28  ?  438 GLN A CA  1 
ATOM   2178 C C   . GLN A 1 449 ? 150.829 149.681 191.120 1.00 19.28  ?  438 GLN A C   1 
ATOM   2179 O O   . GLN A 1 449 ? 151.469 150.352 190.309 1.00 19.28  ?  438 GLN A O   1 
ATOM   2180 C CB  . GLN A 1 449 ? 149.349 151.246 192.353 1.00 19.28  ?  438 GLN A CB  1 
ATOM   2181 C CG  . GLN A 1 449 ? 149.864 150.966 193.722 1.00 19.28  ?  438 GLN A CG  1 
ATOM   2182 C CD  . GLN A 1 449 ? 150.193 152.212 194.473 1.00 19.28  ?  438 GLN A CD  1 
ATOM   2183 O OE1 . GLN A 1 449 ? 150.617 153.195 193.895 1.00 19.28  ?  438 GLN A OE1 1 
ATOM   2184 N NE2 . GLN A 1 449 ? 150.004 152.180 195.770 1.00 19.28  ?  438 GLN A NE2 1 
ATOM   2185 N N   . ALA A 1 450 ? 151.359 148.644 191.761 1.00 22.92  ?  439 ALA A N   1 
ATOM   2186 C CA  . ALA A 1 450 ? 152.711 148.217 191.444 1.00 22.92  ?  439 ALA A CA  1 
ATOM   2187 C C   . ALA A 1 450 ? 152.979 146.720 191.512 1.00 22.92  ?  439 ALA A C   1 
ATOM   2188 O O   . ALA A 1 450 ? 154.114 146.330 191.256 1.00 22.92  ?  439 ALA A O   1 
ATOM   2189 C CB  . ALA A 1 450 ? 153.689 148.939 192.375 1.00 22.92  ?  439 ALA A CB  1 
ATOM   2190 N N   . ARG A 1 451 ? 152.018 145.865 191.825 1.00 30.17  ?  440 ARG A N   1 
ATOM   2191 C CA  . ARG A 1 451 ? 152.343 144.506 192.232 1.00 30.17  ?  440 ARG A CA  1 
ATOM   2192 C C   . ARG A 1 451 ? 151.923 143.466 191.204 1.00 30.17  ?  440 ARG A C   1 
ATOM   2193 O O   . ARG A 1 451 ? 151.119 143.725 190.310 1.00 30.17  ?  440 ARG A O   1 
ATOM   2194 C CB  . ARG A 1 451 ? 151.704 144.173 193.582 1.00 30.17  ?  440 ARG A CB  1 
ATOM   2195 C CG  . ARG A 1 451 ? 152.180 145.030 194.728 1.00 30.17  ?  440 ARG A CG  1 
ATOM   2196 C CD  . ARG A 1 451 ? 153.475 144.523 195.313 1.00 30.17  ?  440 ARG A CD  1 
ATOM   2197 N NE  . ARG A 1 451 ? 154.634 145.009 194.573 1.00 30.17  ?  440 ARG A NE  1 
ATOM   2198 C CZ  . ARG A 1 451 ? 155.232 146.177 194.781 1.00 30.17  ?  440 ARG A CZ  1 
ATOM   2199 N NH1 . ARG A 1 451 ? 156.274 146.524 194.038 1.00 30.17  1  440 ARG A NH1 1 
ATOM   2200 N NH2 . ARG A 1 451 ? 154.799 146.992 195.733 1.00 30.17  ?  440 ARG A NH2 1 
ATOM   2201 N N   . LEU A 1 452 ? 152.474 142.267 191.361 1.00 28.69  ?  441 LEU A N   1 
ATOM   2202 C CA  . LEU A 1 452 ? 152.244 141.157 190.456 1.00 28.69  ?  441 LEU A CA  1 
ATOM   2203 C C   . LEU A 1 452 ? 150.852 140.576 190.649 1.00 28.69  ?  441 LEU A C   1 
ATOM   2204 O O   . LEU A 1 452 ? 150.192 140.805 191.656 1.00 28.69  ?  441 LEU A O   1 
ATOM   2205 C CB  . LEU A 1 452 ? 153.282 140.071 190.682 1.00 28.69  ?  441 LEU A CB  1 
ATOM   2206 C CG  . LEU A 1 452 ? 154.713 140.356 190.270 1.00 28.69  ?  441 LEU A CG  1 
ATOM   2207 C CD1 . LEU A 1 452 ? 155.647 139.330 190.868 1.00 28.69  ?  441 LEU A CD1 1 
ATOM   2208 C CD2 . LEU A 1 452 ? 154.796 140.322 188.780 1.00 28.69  ?  441 LEU A CD2 1 
ATOM   2209 N N   . LEU A 1 453 ? 150.403 139.803 189.667 1.00 27.83  ?  442 LEU A N   1 
ATOM   2210 C CA  . LEU A 1 453 ? 149.120 139.136 189.815 1.00 27.83  ?  442 LEU A CA  1 
ATOM   2211 C C   . LEU A 1 453 ? 149.209 137.982 190.793 1.00 27.83  ?  442 LEU A C   1 
ATOM   2212 O O   . LEU A 1 453 ? 148.204 137.610 191.404 1.00 27.83  ?  442 LEU A O   1 
ATOM   2213 C CB  . LEU A 1 453 ? 148.617 138.621 188.473 1.00 27.83  ?  442 LEU A CB  1 
ATOM   2214 C CG  . LEU A 1 453 ? 148.260 139.579 187.350 1.00 27.83  ?  442 LEU A CG  1 
ATOM   2215 C CD1 . LEU A 1 453 ? 147.336 138.904 186.366 1.00 27.83  ?  442 LEU A CD1 1 
ATOM   2216 C CD2 . LEU A 1 453 ? 147.616 140.783 187.907 1.00 27.83  ?  442 LEU A CD2 1 
ATOM   2217 N N   . THR A 1 454 ? 150.398 137.406 190.956 1.00 31.74  ?  443 THR A N   1 
ATOM   2218 C CA  . THR A 1 454 ? 150.595 136.324 191.905 1.00 31.74  ?  443 THR A CA  1 
ATOM   2219 C C   . THR A 1 454 ? 150.875 136.821 193.308 1.00 31.74  ?  443 THR A C   1 
ATOM   2220 O O   . THR A 1 454 ? 151.332 136.042 194.141 1.00 31.74  ?  443 THR A O   1 
ATOM   2221 C CB  . THR A 1 454 ? 151.723 135.416 191.450 1.00 31.74  ?  443 THR A CB  1 
ATOM   2222 O OG1 . THR A 1 454 ? 152.949 136.143 191.462 1.00 31.74  ?  443 THR A OG1 1 
ATOM   2223 C CG2 . THR A 1 454 ? 151.454 134.922 190.060 1.00 31.74  ?  443 THR A CG2 1 
ATOM   2224 N N   . SER A 1 455 ? 150.662 138.102 193.572 1.00 31.03  ?  444 SER A N   1 
ATOM   2225 C CA  . SER A 1 455 ? 150.511 138.577 194.932 1.00 31.03  ?  444 SER A CA  1 
ATOM   2226 C C   . SER A 1 455 ? 149.093 138.403 195.453 1.00 31.03  ?  444 SER A C   1 
ATOM   2227 O O   . SER A 1 455 ? 148.885 138.483 196.664 1.00 31.03  ?  444 SER A O   1 
ATOM   2228 C CB  . SER A 1 455 ? 150.905 140.042 195.007 1.00 31.03  ?  444 SER A CB  1 
ATOM   2229 O OG  . SER A 1 455 ? 152.232 140.217 194.573 1.00 31.03  ?  444 SER A OG  1 
ATOM   2230 N N   . PHE A 1 456 ? 148.120 138.181 194.575 1.00 32.04  ?  445 PHE A N   1 
ATOM   2231 C CA  . PHE A 1 456 ? 146.717 138.153 194.959 1.00 32.04  ?  445 PHE A CA  1 
ATOM   2232 C C   . PHE A 1 456 ? 145.973 136.913 194.517 1.00 32.04  ?  445 PHE A C   1 
ATOM   2233 O O   . PHE A 1 456 ? 144.931 136.612 195.102 1.00 32.04  ?  445 PHE A O   1 
ATOM   2234 C CB  . PHE A 1 456 ? 145.961 139.363 194.388 1.00 32.04  ?  445 PHE A CB  1 
ATOM   2235 C CG  . PHE A 1 456 ? 146.694 140.665 194.495 1.00 32.04  ?  445 PHE A CG  1 
ATOM   2236 C CD1 . PHE A 1 456 ? 146.699 141.372 195.678 1.00 32.04  ?  445 PHE A CD1 1 
ATOM   2237 C CD2 . PHE A 1 456 ? 147.343 141.199 193.400 1.00 32.04  ?  445 PHE A CD2 1 
ATOM   2238 C CE1 . PHE A 1 456 ? 147.353 142.577 195.771 1.00 32.04  ?  445 PHE A CE1 1 
ATOM   2239 C CE2 . PHE A 1 456 ? 148.000 142.396 193.488 1.00 32.04  ?  445 PHE A CE2 1 
ATOM   2240 C CZ  . PHE A 1 456 ? 148.006 143.087 194.671 1.00 32.04  ?  445 PHE A CZ  1 
ATOM   2241 N N   . LEU A 1 457 ? 146.432 136.210 193.506 1.00 32.59  ?  446 LEU A N   1 
ATOM   2242 C CA  . LEU A 1 457 ? 145.648 135.109 192.991 1.00 32.59  ?  446 LEU A CA  1 
ATOM   2243 C C   . LEU A 1 457 ? 146.409 133.803 193.111 1.00 32.59  ?  446 LEU A C   1 
ATOM   2244 O O   . LEU A 1 457 ? 147.637 133.782 193.004 1.00 32.59  ?  446 LEU A O   1 
ATOM   2245 C CB  . LEU A 1 457 ? 145.288 135.317 191.519 1.00 32.59  ?  446 LEU A CB  1 
ATOM   2246 C CG  . LEU A 1 457 ? 144.710 136.652 191.085 1.00 32.59  ?  446 LEU A CG  1 
ATOM   2247 C CD1 . LEU A 1 457 ? 144.824 136.758 189.595 1.00 32.59  ?  446 LEU A CD1 1 
ATOM   2248 C CD2 . LEU A 1 457 ? 143.286 136.765 191.514 1.00 32.59  ?  446 LEU A CD2 1 
ATOM   2249 N N   . PRO A 1 458 ? 145.711 132.694 193.329 1.00 36.56  ?  447 PRO A N   1 
ATOM   2250 C CA  . PRO A 1 458 ? 146.343 131.386 193.170 1.00 36.56  ?  447 PRO A CA  1 
ATOM   2251 C C   . PRO A 1 458 ? 146.699 131.148 191.714 1.00 36.56  ?  447 PRO A C   1 
ATOM   2252 O O   . PRO A 1 458 ? 146.152 131.767 190.804 1.00 36.56  ?  447 PRO A O   1 
ATOM   2253 C CB  . PRO A 1 458 ? 145.266 130.415 193.644 1.00 36.56  ?  447 PRO A CB  1 
ATOM   2254 C CG  . PRO A 1 458 ? 144.000 131.157 193.494 1.00 36.56  ?  447 PRO A CG  1 
ATOM   2255 C CD  . PRO A 1 458 ? 144.323 132.569 193.798 1.00 36.56  ?  447 PRO A CD  1 
ATOM   2256 N N   . ALA A 1 459 ? 147.614 130.207 191.493 1.00 36.65  ?  448 ALA A N   1 
ATOM   2257 C CA  . ALA A 1 459 ? 148.131 129.975 190.153 1.00 36.65  ?  448 ALA A CA  1 
ATOM   2258 C C   . ALA A 1 459 ? 147.113 129.352 189.209 1.00 36.65  ?  448 ALA A C   1 
ATOM   2259 O O   . ALA A 1 459 ? 147.342 129.353 187.997 1.00 36.65  ?  448 ALA A O   1 
ATOM   2260 C CB  . ALA A 1 459 ? 149.369 129.094 190.219 1.00 36.65  ?  448 ALA A CB  1 
ATOM   2261 N N   . GLN A 1 460 ? 145.997 128.851 189.715 1.00 40.52  ?  449 GLN A N   1 
ATOM   2262 C CA  . GLN A 1 460 ? 144.954 128.311 188.863 1.00 40.52  ?  449 GLN A CA  1 
ATOM   2263 C C   . GLN A 1 460 ? 143.970 129.364 188.376 1.00 40.52  ?  449 GLN A C   1 
ATOM   2264 O O   . GLN A 1 460 ? 143.012 129.018 187.684 1.00 40.52  ?  449 GLN A O   1 
ATOM   2265 C CB  . GLN A 1 460 ? 144.203 127.199 189.592 1.00 40.52  ?  449 GLN A CB  1 
ATOM   2266 C CG  . GLN A 1 460 ? 143.547 127.633 190.870 1.00 40.52  ?  449 GLN A CG  1 
ATOM   2267 C CD  . GLN A 1 460 ? 144.352 127.219 192.076 1.00 40.52  ?  449 GLN A CD  1 
ATOM   2268 O OE1 . GLN A 1 460 ? 145.495 126.793 191.950 1.00 40.52  ?  449 GLN A OE1 1 
ATOM   2269 N NE2 . GLN A 1 460 ? 143.752 127.319 193.254 1.00 40.52  ?  449 GLN A NE2 1 
ATOM   2270 N N   . LEU A 1 461 ? 144.180 130.636 188.705 1.00 31.79  ?  450 LEU A N   1 
ATOM   2271 C CA  . LEU A 1 461 ? 143.304 131.701 188.242 1.00 31.79  ?  450 LEU A CA  1 
ATOM   2272 C C   . LEU A 1 461 ? 144.009 132.703 187.341 1.00 31.79  ?  450 LEU A C   1 
ATOM   2273 O O   . LEU A 1 461 ? 143.399 133.699 186.963 1.00 31.79  ?  450 LEU A O   1 
ATOM   2274 C CB  . LEU A 1 461 ? 142.687 132.431 189.430 1.00 31.79  ?  450 LEU A CB  1 
ATOM   2275 C CG  . LEU A 1 461 ? 141.589 131.733 190.217 1.00 31.79  ?  450 LEU A CG  1 
ATOM   2276 C CD1 . LEU A 1 461 ? 141.148 132.639 191.327 1.00 31.79  ?  450 LEU A CD1 1 
ATOM   2277 C CD2 . LEU A 1 461 ? 140.444 131.421 189.322 1.00 31.79  ?  450 LEU A CD2 1 
ATOM   2278 N N   . LEU A 1 462 ? 145.271 132.471 186.991 1.00 29.18  ?  451 LEU A N   1 
ATOM   2279 C CA  . LEU A 1 462 ? 146.039 133.482 186.280 1.00 29.18  ?  451 LEU A CA  1 
ATOM   2280 C C   . LEU A 1 462 ? 145.634 133.572 184.821 1.00 29.18  ?  451 LEU A C   1 
ATOM   2281 O O   . LEU A 1 462 ? 145.626 134.662 184.242 1.00 29.18  ?  451 LEU A O   1 
ATOM   2282 C CB  . LEU A 1 462 ? 147.523 133.179 186.388 1.00 29.18  ?  451 LEU A CB  1 
ATOM   2283 C CG  . LEU A 1 462 ? 148.105 132.929 187.767 1.00 29.18  ?  451 LEU A CG  1 
ATOM   2284 C CD1 . LEU A 1 462 ? 149.591 132.687 187.643 1.00 29.18  ?  451 LEU A CD1 1 
ATOM   2285 C CD2 . LEU A 1 462 ? 147.837 134.106 188.645 1.00 29.18  ?  451 LEU A CD2 1 
ATOM   2286 N N   . ARG A 1 463 ? 145.297 132.441 184.209 1.00 29.81  ?  452 ARG A N   1 
ATOM   2287 C CA  . ARG A 1 463 ? 144.836 132.446 182.825 1.00 29.81  ?  452 ARG A CA  1 
ATOM   2288 C C   . ARG A 1 463 ? 143.474 133.094 182.688 1.00 29.81  ?  452 ARG A C   1 
ATOM   2289 O O   . ARG A 1 463 ? 143.216 133.795 181.707 1.00 29.81  ?  452 ARG A O   1 
ATOM   2290 C CB  . ARG A 1 463 ? 144.772 131.023 182.306 1.00 29.81  ?  452 ARG A CB  1 
ATOM   2291 C CG  . ARG A 1 463 ? 146.081 130.339 182.311 1.00 29.81  ?  452 ARG A CG  1 
ATOM   2292 C CD  . ARG A 1 463 ? 145.960 128.877 182.004 1.00 29.81  ?  452 ARG A CD  1 
ATOM   2293 N NE  . ARG A 1 463 ? 147.276 128.266 182.040 1.00 29.81  ?  452 ARG A NE  1 
ATOM   2294 C CZ  . ARG A 1 463 ? 148.026 128.086 180.967 1.00 29.81  ?  452 ARG A CZ  1 
ATOM   2295 N NH1 . ARG A 1 463 ? 147.570 128.439 179.774 1.00 29.81  1  452 ARG A NH1 1 
ATOM   2296 N NH2 . ARG A 1 463 ? 149.222 127.537 181.089 1.00 29.81  ?  452 ARG A NH2 1 
ATOM   2297 N N   . LEU A 1 464 ? 142.609 132.879 183.672 1.00 30.41  ?  453 LEU A N   1 
ATOM   2298 C CA  . LEU A 1 464 ? 141.278 133.464 183.678 1.00 30.41  ?  453 LEU A CA  1 
ATOM   2299 C C   . LEU A 1 464 ? 141.339 134.975 183.809 1.00 30.41  ?  453 LEU A C   1 
ATOM   2300 O O   . LEU A 1 464 ? 140.659 135.704 183.081 1.00 30.41  ?  453 LEU A O   1 
ATOM   2301 C CB  . LEU A 1 464 ? 140.501 132.859 184.835 1.00 30.41  ?  453 LEU A CB  1 
ATOM   2302 C CG  . LEU A 1 464 ? 139.024 132.637 184.690 1.00 30.41  ?  453 LEU A CG  1 
ATOM   2303 C CD1 . LEU A 1 464 ? 138.843 131.713 183.548 1.00 30.41  ?  453 LEU A CD1 1 
ATOM   2304 C CD2 . LEU A 1 464 ? 138.588 132.002 185.941 1.00 30.41  ?  453 LEU A CD2 1 
ATOM   2305 N N   . TYR A 1 465 ? 142.180 135.460 184.714 1.00 26.30  ?  454 TYR A N   1 
ATOM   2306 C CA  . TYR A 1 465 ? 142.361 136.889 184.901 1.00 26.30  ?  454 TYR A CA  1 
ATOM   2307 C C   . TYR A 1 465 ? 143.088 137.528 183.738 1.00 26.30  ?  454 TYR A C   1 
ATOM   2308 O O   . TYR A 1 465 ? 142.851 138.698 183.445 1.00 26.30  ?  454 TYR A O   1 
ATOM   2309 C CB  . TYR A 1 465 ? 143.078 137.113 186.223 1.00 26.30  ?  454 TYR A CB  1 
ATOM   2310 C CG  . TYR A 1 465 ? 142.116 137.449 187.324 1.00 26.30  ?  454 TYR A CG  1 
ATOM   2311 C CD1 . TYR A 1 465 ? 141.623 138.729 187.463 1.00 26.30  ?  454 TYR A CD1 1 
ATOM   2312 C CD2 . TYR A 1 465 ? 141.571 136.455 188.109 1.00 26.30  ?  454 TYR A CD2 1 
ATOM   2313 C CE1 . TYR A 1 465 ? 140.725 139.036 188.440 1.00 26.30  ?  454 TYR A CE1 1 
ATOM   2314 C CE2 . TYR A 1 465 ? 140.659 136.747 189.080 1.00 26.30  ?  454 TYR A CE2 1 
ATOM   2315 C CZ  . TYR A 1 465 ? 140.239 138.042 189.243 1.00 26.30  ?  454 TYR A CZ  1 
ATOM   2316 O OH  . TYR A 1 465 ? 139.320 138.338 190.217 1.00 26.30  ?  454 TYR A OH  1 
ATOM   2317 N N   . GLN A 1 466 ? 143.936 136.784 183.038 1.00 24.40  ?  455 GLN A N   1 
ATOM   2318 C CA  . GLN A 1 466 ? 144.564 137.350 181.854 1.00 24.40  ?  455 GLN A CA  1 
ATOM   2319 C C   . GLN A 1 466 ? 143.620 137.385 180.664 1.00 24.40  ?  455 GLN A C   1 
ATOM   2320 O O   . GLN A 1 466 ? 143.757 138.250 179.803 1.00 24.40  ?  455 GLN A O   1 
ATOM   2321 C CB  . GLN A 1 466 ? 145.818 136.575 181.516 1.00 24.40  ?  455 GLN A CB  1 
ATOM   2322 C CG  . GLN A 1 466 ? 146.975 136.994 182.345 1.00 24.40  ?  455 GLN A CG  1 
ATOM   2323 C CD  . GLN A 1 466 ? 148.254 136.478 181.809 1.00 24.40  ?  455 GLN A CD  1 
ATOM   2324 O OE1 . GLN A 1 466 ? 148.290 135.873 180.746 1.00 24.40  ?  455 GLN A OE1 1 
ATOM   2325 N NE2 . GLN A 1 466 ? 149.328 136.710 182.537 1.00 24.40  ?  455 GLN A NE2 1 
ATOM   2326 N N   . LEU A 1 467 ? 142.681 136.459 180.577 1.00 20.28  ?  456 LEU A N   1 
ATOM   2327 C CA  . LEU A 1 467 ? 141.650 136.589 179.560 1.00 20.28  ?  456 LEU A CA  1 
ATOM   2328 C C   . LEU A 1 467 ? 140.699 137.731 179.880 1.00 20.28  ?  456 LEU A C   1 
ATOM   2329 O O   . LEU A 1 467 ? 140.223 138.404 178.965 1.00 20.28  ?  456 LEU A O   1 
ATOM   2330 C CB  . LEU A 1 467 ? 140.885 135.271 179.419 1.00 20.28  ?  456 LEU A CB  1 
ATOM   2331 C CG  . LEU A 1 467 ? 139.731 135.171 178.419 1.00 20.28  ?  456 LEU A CG  1 
ATOM   2332 C CD1 . LEU A 1 467 ? 140.216 135.409 177.040 1.00 20.28  ?  456 LEU A CD1 1 
ATOM   2333 C CD2 . LEU A 1 467 ? 139.082 133.839 178.491 1.00 20.28  ?  456 LEU A CD2 1 
ATOM   2334 N N   . MET A 1 468 ? 140.424 137.970 181.164 1.00 16.68  ?  457 MET A N   1 
ATOM   2335 C CA  . MET A 1 468 ? 139.530 139.056 181.547 1.00 16.68  ?  457 MET A CA  1 
ATOM   2336 C C   . MET A 1 468 ? 140.167 140.416 181.320 1.00 16.68  ?  457 MET A C   1 
ATOM   2337 O O   . MET A 1 468 ? 139.524 141.322 180.792 1.00 16.68  ?  457 MET A O   1 
ATOM   2338 C CB  . MET A 1 468 ? 139.115 138.910 183.005 1.00 16.68  ?  457 MET A CB  1 
ATOM   2339 C CG  . MET A 1 468 ? 137.918 139.729 183.378 1.00 16.68  ?  457 MET A CG  1 
ATOM   2340 S SD  . MET A 1 468 ? 137.707 139.928 185.129 1.00 16.68  ?  457 MET A SD  1 
ATOM   2341 C CE  . MET A 1 468 ? 139.136 140.905 185.524 1.00 16.68  ?  457 MET A CE  1 
ATOM   2342 N N   . LEU A 1 469 ? 141.434 140.579 181.689 1.00 13.49  ?  458 LEU A N   1 
ATOM   2343 C CA  . LEU A 1 469 ? 142.058 141.893 181.610 1.00 13.49  ?  458 LEU A CA  1 
ATOM   2344 C C   . LEU A 1 469 ? 142.294 142.367 180.184 1.00 13.49  ?  458 LEU A C   1 
ATOM   2345 O O   . LEU A 1 469 ? 142.398 143.571 179.963 1.00 13.49  ?  458 LEU A O   1 
ATOM   2346 C CB  . LEU A 1 469 ? 143.380 141.898 182.363 1.00 13.49  ?  458 LEU A CB  1 
ATOM   2347 C CG  . LEU A 1 469 ? 143.381 142.029 183.885 1.00 13.49  ?  458 LEU A CG  1 
ATOM   2348 C CD1 . LEU A 1 469 ? 144.716 142.562 184.318 1.00 13.49  ?  458 LEU A CD1 1 
ATOM   2349 C CD2 . LEU A 1 469 ? 142.278 142.894 184.415 1.00 13.49  ?  458 LEU A CD2 1 
ATOM   2350 N N   . PHE A 1 470 ? 142.340 141.468 179.215 1.00 12.31  ?  459 PHE A N   1 
ATOM   2351 C CA  . PHE A 1 470 ? 142.545 141.844 177.828 1.00 12.31  ?  459 PHE A CA  1 
ATOM   2352 C C   . PHE A 1 470 ? 141.256 142.102 177.065 1.00 12.31  ?  459 PHE A C   1 
ATOM   2353 O O   . PHE A 1 470 ? 141.310 142.663 175.975 1.00 12.31  ?  459 PHE A O   1 
ATOM   2354 C CB  . PHE A 1 470 ? 143.330 140.757 177.105 1.00 12.31  ?  459 PHE A CB  1 
ATOM   2355 C CG  . PHE A 1 470 ? 144.796 140.957 177.128 1.00 12.31  ?  459 PHE A CG  1 
ATOM   2356 C CD1 . PHE A 1 470 ? 145.387 141.936 176.369 1.00 12.31  ?  459 PHE A CD1 1 
ATOM   2357 C CD2 . PHE A 1 470 ? 145.589 140.156 177.907 1.00 12.31  ?  459 PHE A CD2 1 
ATOM   2358 C CE1 . PHE A 1 470 ? 146.736 142.115 176.399 1.00 12.31  ?  459 PHE A CE1 1 
ATOM   2359 C CE2 . PHE A 1 470 ? 146.937 140.329 177.935 1.00 12.31  ?  459 PHE A CE2 1 
ATOM   2360 C CZ  . PHE A 1 470 ? 147.509 141.310 177.181 1.00 12.31  ?  459 PHE A CZ  1 
ATOM   2361 N N   . THR A 1 471 ? 140.105 141.680 177.570 1.00 11.88  ?  460 THR A N   1 
ATOM   2362 C CA  . THR A 1 471 ? 138.867 141.832 176.828 1.00 11.88  ?  460 THR A CA  1 
ATOM   2363 C C   . THR A 1 471 ? 137.863 142.729 177.537 1.00 11.88  ?  460 THR A C   1 
ATOM   2364 O O   . THR A 1 471 ? 136.691 142.728 177.181 1.00 11.88  ?  460 THR A O   1 
ATOM   2365 C CB  . THR A 1 471 ? 138.244 140.467 176.529 1.00 11.88  ?  460 THR A CB  1 
ATOM   2366 O OG1 . THR A 1 471 ? 138.067 139.736 177.741 1.00 11.88  ?  460 THR A OG1 1 
ATOM   2367 C CG2 . THR A 1 471 ? 139.128 139.655 175.618 1.00 11.88  ?  460 THR A CG2 1 
ATOM   2368 N N   . LEU A 1 472 ? 138.271 143.452 178.481 1.00 9.45   ?  461 LEU A N   1 
ATOM   2369 C CA  . LEU A 1 472 ? 137.496 144.506 179.106 1.00 9.45   ?  461 LEU A CA  1 
ATOM   2370 C C   . LEU A 1 472 ? 137.827 145.842 178.452 1.00 9.45   ?  461 LEU A C   1 
ATOM   2371 O O   . LEU A 1 472 ? 138.956 146.058 178.029 1.00 9.45   ?  461 LEU A O   1 
ATOM   2372 C CB  . LEU A 1 472 ? 137.773 144.572 180.614 1.00 9.45   ?  461 LEU A CB  1 
ATOM   2373 C CG  . LEU A 1 472 ? 137.165 143.498 181.529 1.00 9.45   ?  461 LEU A CG  1 
ATOM   2374 C CD1 . LEU A 1 472 ? 137.660 143.648 182.920 1.00 9.45   ?  461 LEU A CD1 1 
ATOM   2375 C CD2 . LEU A 1 472 ? 135.673 143.487 181.532 1.00 9.45   ?  461 LEU A CD2 1 
ATOM   2376 N N   . PRO A 1 473 ? 136.872 146.763 178.323 1.00 8.14   ?  462 PRO A N   1 
ATOM   2377 C CA  . PRO A 1 473 ? 137.103 148.024 177.602 1.00 8.14   ?  462 PRO A CA  1 
ATOM   2378 C C   . PRO A 1 473 ? 137.954 149.087 178.287 1.00 8.14   ?  462 PRO A C   1 
ATOM   2379 O O   . PRO A 1 473 ? 137.482 150.048 178.860 1.00 8.14   ?  462 PRO A O   1 
ATOM   2380 C CB  . PRO A 1 473 ? 135.682 148.539 177.389 1.00 8.14   ?  462 PRO A CB  1 
ATOM   2381 C CG  . PRO A 1 473 ? 134.927 147.957 178.465 1.00 8.14   ?  462 PRO A CG  1 
ATOM   2382 C CD  . PRO A 1 473 ? 135.457 146.621 178.687 1.00 8.14   ?  462 PRO A CD  1 
ATOM   2383 N N   . GLY A 1 474 ? 139.261 148.940 178.216 1.00 7.97   ?  463 GLY A N   1 
ATOM   2384 C CA  . GLY A 1 474 ? 140.129 149.942 178.782 1.00 7.97   ?  463 GLY A CA  1 
ATOM   2385 C C   . GLY A 1 474 ? 141.569 149.611 178.511 1.00 7.97   ?  463 GLY A C   1 
ATOM   2386 O O   . GLY A 1 474 ? 141.859 148.920 177.542 1.00 7.97   ?  463 GLY A O   1 
ATOM   2387 N N   . THR A 1 475 ? 142.483 150.074 179.351 1.00 9.44   ?  464 THR A N   1 
ATOM   2388 C CA  . THR A 1 475 ? 143.894 149.809 179.168 1.00 9.44   ?  464 THR A CA  1 
ATOM   2389 C C   . THR A 1 475 ? 144.355 148.785 180.188 1.00 9.44   ?  464 THR A C   1 
ATOM   2390 O O   . THR A 1 475 ? 144.373 149.092 181.384 1.00 9.44   ?  464 THR A O   1 
ATOM   2391 C CB  . THR A 1 475 ? 144.709 151.093 179.292 1.00 9.44   ?  464 THR A CB  1 
ATOM   2392 O OG1 . THR A 1 475 ? 144.307 152.002 178.274 1.00 9.44   ?  464 THR A OG1 1 
ATOM   2393 C CG2 . THR A 1 475 ? 146.161 150.815 179.085 1.00 9.44   ?  464 THR A CG2 1 
ATOM   2394 N N   . PRO A 1 476 ? 144.726 147.572 179.781 1.00 11.00  ?  465 PRO A N   1 
ATOM   2395 C CA  . PRO A 1 476 ? 145.292 146.612 180.735 1.00 11.00  ?  465 PRO A CA  1 
ATOM   2396 C C   . PRO A 1 476 ? 146.713 146.993 181.113 1.00 11.00  ?  465 PRO A C   1 
ATOM   2397 O O   . PRO A 1 476 ? 147.512 147.348 180.253 1.00 11.00  ?  465 PRO A O   1 
ATOM   2398 C CB  . PRO A 1 476 ? 145.256 145.289 179.964 1.00 11.00  ?  465 PRO A CB  1 
ATOM   2399 C CG  . PRO A 1 476 ? 145.175 145.659 178.542 1.00 11.00  ?  465 PRO A CG  1 
ATOM   2400 C CD  . PRO A 1 476 ? 144.569 146.999 178.434 1.00 11.00  ?  465 PRO A CD  1 
ATOM   2401 N N   . VAL A 1 477 ? 147.024 146.960 182.402 1.00 25.17  ?  466 VAL A N   1 
ATOM   2402 C CA  . VAL A 1 477 ? 148.359 147.304 182.881 1.00 25.17  ?  466 VAL A CA  1 
ATOM   2403 C C   . VAL A 1 477 ? 148.901 146.143 183.704 1.00 25.17  ?  466 VAL A C   1 
ATOM   2404 O O   . VAL A 1 477 ? 148.225 145.657 184.613 1.00 25.17  ?  466 VAL A O   1 
ATOM   2405 C CB  . VAL A 1 477 ? 148.375 148.608 183.702 1.00 25.17  ?  466 VAL A CB  1 
ATOM   2406 C CG1 . VAL A 1 477 ? 149.781 148.998 184.000 1.00 25.17  ?  466 VAL A CG1 1 
ATOM   2407 C CG2 . VAL A 1 477 ? 147.716 149.738 182.967 1.00 25.17  ?  466 VAL A CG2 1 
ATOM   2408 N N   . PHE A 1 478 ? 150.123 145.707 183.387 1.00 14.69  ?  467 PHE A N   1 
ATOM   2409 C CA  . PHE A 1 478 ? 150.789 144.573 184.011 1.00 14.69  ?  467 PHE A CA  1 
ATOM   2410 C C   . PHE A 1 478 ? 152.169 145.001 184.478 1.00 14.69  ?  467 PHE A C   1 
ATOM   2411 O O   . PHE A 1 478 ? 152.752 145.935 183.938 1.00 14.69  ?  467 PHE A O   1 
ATOM   2412 C CB  . PHE A 1 478 ? 150.948 143.405 183.035 1.00 14.69  ?  467 PHE A CB  1 
ATOM   2413 C CG  . PHE A 1 478 ? 149.675 142.954 182.389 1.00 14.69  ?  467 PHE A CG  1 
ATOM   2414 C CD1 . PHE A 1 478 ? 148.921 141.951 182.949 1.00 14.69  ?  467 PHE A CD1 1 
ATOM   2415 C CD2 . PHE A 1 478 ? 149.261 143.491 181.191 1.00 14.69  ?  467 PHE A CD2 1 
ATOM   2416 C CE1 . PHE A 1 478 ? 147.764 141.528 182.352 1.00 14.69  ?  467 PHE A CE1 1 
ATOM   2417 C CE2 . PHE A 1 478 ? 148.100 143.073 180.594 1.00 14.69  ?  467 PHE A CE2 1 
ATOM   2418 C CZ  . PHE A 1 478 ? 147.357 142.091 181.174 1.00 14.69  ?  467 PHE A CZ  1 
ATOM   2419 N N   . SER A 1 479 ? 152.711 144.297 185.467 1.00 19.60  ?  468 SER A N   1 
ATOM   2420 C CA  . SER A 1 479 ? 154.120 144.427 185.813 1.00 19.60  ?  468 SER A CA  1 
ATOM   2421 C C   . SER A 1 479 ? 154.934 143.345 185.112 1.00 19.60  ?  468 SER A C   1 
ATOM   2422 O O   . SER A 1 479 ? 154.395 142.432 184.493 1.00 19.60  ?  468 SER A O   1 
ATOM   2423 C CB  . SER A 1 479 ? 154.337 144.369 187.320 1.00 19.60  ?  468 SER A CB  1 
ATOM   2424 O OG  . SER A 1 479 ? 153.919 145.552 187.958 1.00 19.60  ?  468 SER A OG  1 
ATOM   2425 N N   . TYR A 1 480 ? 156.254 143.450 185.212 1.00 26.84  ?  469 TYR A N   1 
ATOM   2426 C CA  . TYR A 1 480 ? 157.141 142.482 184.583 1.00 26.84  ?  469 TYR A CA  1 
ATOM   2427 C C   . TYR A 1 480 ? 157.052 141.144 185.296 1.00 26.84  ?  469 TYR A C   1 
ATOM   2428 O O   . TYR A 1 480 ? 157.058 141.084 186.525 1.00 26.84  ?  469 TYR A O   1 
ATOM   2429 C CB  . TYR A 1 480 ? 158.586 142.995 184.551 1.00 26.84  ?  469 TYR A CB  1 
ATOM   2430 C CG  . TYR A 1 480 ? 159.375 142.947 185.841 1.00 26.84  ?  469 TYR A CG  1 
ATOM   2431 C CD1 . TYR A 1 480 ? 159.367 144.007 186.717 1.00 26.84  ?  469 TYR A CD1 1 
ATOM   2432 C CD2 . TYR A 1 480 ? 160.162 141.845 186.157 1.00 26.84  ?  469 TYR A CD2 1 
ATOM   2433 C CE1 . TYR A 1 480 ? 160.096 143.960 187.879 1.00 26.84  ?  469 TYR A CE1 1 
ATOM   2434 C CE2 . TYR A 1 480 ? 160.874 141.788 187.310 1.00 26.84  ?  469 TYR A CE2 1 
ATOM   2435 C CZ  . TYR A 1 480 ? 160.845 142.844 188.161 1.00 26.84  ?  469 TYR A CZ  1 
ATOM   2436 O OH  . TYR A 1 480 ? 161.567 142.781 189.314 1.00 26.84  ?  469 TYR A OH  1 
ATOM   2437 N N   . GLY A 1 481 ? 156.956 140.075 184.525 1.00 28.05  ?  470 GLY A N   1 
ATOM   2438 C CA  . GLY A 1 481 ? 156.774 138.760 185.081 1.00 28.05  ?  470 GLY A CA  1 
ATOM   2439 C C   . GLY A 1 481 ? 155.345 138.295 185.150 1.00 28.05  ?  470 GLY A C   1 
ATOM   2440 O O   . GLY A 1 481 ? 155.105 137.164 185.556 1.00 28.05  ?  470 GLY A O   1 
ATOM   2441 N N   . ASP A 1 482 ? 154.388 139.138 184.790 1.00 30.24  ?  471 ASP A N   1 
ATOM   2442 C CA  . ASP A 1 482 ? 153.004 138.702 184.760 1.00 30.24  ?  471 ASP A CA  1 
ATOM   2443 C C   . ASP A 1 482 ? 152.720 137.806 183.577 1.00 30.24  ?  471 ASP A C   1 
ATOM   2444 O O   . ASP A 1 482 ? 151.771 137.021 183.625 1.00 30.24  ?  471 ASP A O   1 
ATOM   2445 C CB  . ASP A 1 482 ? 152.067 139.904 184.733 1.00 30.24  ?  471 ASP A CB  1 
ATOM   2446 C CG  . ASP A 1 482 ? 151.884 140.522 186.089 1.00 30.24  ?  471 ASP A CG  1 
ATOM   2447 O OD1 . ASP A 1 482 ? 151.969 139.787 187.083 1.00 30.24  ?  471 ASP A OD1 1 
ATOM   2448 O OD2 . ASP A 1 482 ? 151.643 141.738 186.176 1.00 30.24  -1 471 ASP A OD2 1 
ATOM   2449 N N   . GLU A 1 483 ? 153.524 137.903 182.528 1.00 28.93  ?  472 GLU A N   1 
ATOM   2450 C CA  . GLU A 1 483 ? 153.313 137.122 181.326 1.00 28.93  ?  472 GLU A CA  1 
ATOM   2451 C C   . GLU A 1 483 ? 153.842 135.701 181.440 1.00 28.93  ?  472 GLU A C   1 
ATOM   2452 O O   . GLU A 1 483 ? 153.343 134.827 180.735 1.00 28.93  ?  472 GLU A O   1 
ATOM   2453 C CB  . GLU A 1 483 ? 153.942 137.842 180.138 1.00 28.93  ?  472 GLU A CB  1 
ATOM   2454 C CG  . GLU A 1 483 ? 155.436 137.814 180.097 1.00 28.93  ?  472 GLU A CG  1 
ATOM   2455 C CD  . GLU A 1 483 ? 156.083 138.959 180.826 1.00 28.93  ?  472 GLU A CD  1 
ATOM   2456 O OE1 . GLU A 1 483 ? 155.379 139.690 181.530 1.00 28.93  ?  472 GLU A OE1 1 
ATOM   2457 O OE2 . GLU A 1 483 ? 157.302 139.136 180.695 1.00 28.93  -1 472 GLU A OE2 1 
ATOM   2458 N N   . ILE A 1 484 ? 154.802 135.429 182.322 1.00 29.13  ?  473 ILE A N   1 
ATOM   2459 C CA  . ILE A 1 484 ? 155.234 134.064 182.573 1.00 29.13  ?  473 ILE A CA  1 
ATOM   2460 C C   . ILE A 1 484 ? 154.636 133.503 183.837 1.00 29.13  ?  473 ILE A C   1 
ATOM   2461 O O   . ILE A 1 484 ? 154.669 132.286 184.033 1.00 29.13  ?  473 ILE A O   1 
ATOM   2462 C CB  . ILE A 1 484 ? 156.767 133.937 182.616 1.00 29.13  ?  473 ILE A CB  1 
ATOM   2463 C CG1 . ILE A 1 484 ? 157.343 134.817 183.703 1.00 29.13  ?  473 ILE A CG1 1 
ATOM   2464 C CG2 . ILE A 1 484 ? 157.375 134.250 181.278 1.00 29.13  ?  473 ILE A CG2 1 
ATOM   2465 C CD1 . ILE A 1 484 ? 158.800 134.677 183.868 1.00 29.13  ?  473 ILE A CD1 1 
ATOM   2466 N N   . GLY A 1 485 ? 154.063 134.338 184.687 1.00 26.73  ?  474 GLY A N   1 
ATOM   2467 C CA  . GLY A 1 485 ? 153.524 133.865 185.939 1.00 26.73  ?  474 GLY A CA  1 
ATOM   2468 C C   . GLY A 1 485 ? 154.526 133.842 187.046 1.00 26.73  ?  474 GLY A C   1 
ATOM   2469 O O   . GLY A 1 485 ? 154.499 132.933 187.869 1.00 26.73  ?  474 GLY A O   1 
ATOM   2470 N N   . LEU A 1 486 ? 155.402 134.833 187.095 1.00 32.27  ?  475 LEU A N   1 
ATOM   2471 C CA  . LEU A 1 486 ? 156.484 134.879 188.066 1.00 32.27  ?  475 LEU A CA  1 
ATOM   2472 C C   . LEU A 1 486 ? 155.943 135.068 189.475 1.00 32.27  ?  475 LEU A C   1 
ATOM   2473 O O   . LEU A 1 486 ? 155.112 135.941 189.725 1.00 32.27  ?  475 LEU A O   1 
ATOM   2474 C CB  . LEU A 1 486 ? 157.441 136.006 187.697 1.00 32.27  ?  475 LEU A CB  1 
ATOM   2475 C CG  . LEU A 1 486 ? 158.452 136.498 188.724 1.00 32.27  ?  475 LEU A CG  1 
ATOM   2476 C CD1 . LEU A 1 486 ? 159.459 135.427 189.032 1.00 32.27  ?  475 LEU A CD1 1 
ATOM   2477 C CD2 . LEU A 1 486 ? 159.159 137.725 188.203 1.00 32.27  ?  475 LEU A CD2 1 
ATOM   2478 N N   . ASP A 1 487 ? 156.392 134.222 190.389 1.00 47.36  ?  476 ASP A N   1 
ATOM   2479 C CA  . ASP A 1 487 ? 155.963 134.249 191.776 1.00 47.36  ?  476 ASP A CA  1 
ATOM   2480 C C   . ASP A 1 487 ? 157.157 134.592 192.646 1.00 47.36  ?  476 ASP A C   1 
ATOM   2481 O O   . ASP A 1 487 ? 158.217 133.977 192.517 1.00 47.36  ?  476 ASP A O   1 
ATOM   2482 C CB  . ASP A 1 487 ? 155.376 132.901 192.186 1.00 47.36  ?  476 ASP A CB  1 
ATOM   2483 C CG  . ASP A 1 487 ? 154.413 133.008 193.339 1.00 47.36  ?  476 ASP A CG  1 
ATOM   2484 O OD1 . ASP A 1 487 ? 154.687 133.761 194.292 1.00 47.36  ?  476 ASP A OD1 1 
ATOM   2485 O OD2 . ASP A 1 487 ? 153.368 132.336 193.292 1.00 47.36  -1 476 ASP A OD2 1 
ATOM   2486 N N   . ALA A 1 488 ? 156.983 135.570 193.529 1.00 51.65  ?  477 ALA A N   1 
ATOM   2487 C CA  . ALA A 1 488 ? 158.055 135.954 194.432 1.00 51.65  ?  477 ALA A CA  1 
ATOM   2488 C C   . ALA A 1 488 ? 158.159 135.036 195.636 1.00 51.65  ?  477 ALA A C   1 
ATOM   2489 O O   . ALA A 1 488 ? 159.144 135.114 196.374 1.00 51.65  ?  477 ALA A O   1 
ATOM   2490 C CB  . ALA A 1 488 ? 157.857 137.388 194.904 1.00 51.65  ?  477 ALA A CB  1 
ATOM   2491 N N   . ALA A 1 489 ? 157.170 134.180 195.856 1.00 55.75  ?  478 ALA A N   1 
ATOM   2492 C CA  . ALA A 1 489 ? 157.212 133.200 196.926 1.00 55.75  ?  478 ALA A CA  1 
ATOM   2493 C C   . ALA A 1 489 ? 157.464 131.790 196.424 1.00 55.75  ?  478 ALA A C   1 
ATOM   2494 O O   . ALA A 1 489 ? 157.400 130.849 197.215 1.00 55.75  ?  478 ALA A O   1 
ATOM   2495 C CB  . ALA A 1 489 ? 155.910 133.236 197.725 1.00 55.75  ?  478 ALA A CB  1 
ATOM   2496 N N   . ALA A 1 490 ? 157.740 131.616 195.136 1.00 60.62  ?  479 ALA A N   1 
ATOM   2497 C CA  . ALA A 1 490 ? 158.048 130.310 194.572 1.00 60.62  ?  479 ALA A CA  1 
ATOM   2498 C C   . ALA A 1 490 ? 159.474 129.871 194.842 1.00 60.62  ?  479 ALA A C   1 
ATOM   2499 O O   . ALA A 1 490 ? 159.803 128.707 194.602 1.00 60.62  ?  479 ALA A O   1 
ATOM   2500 C CB  . ALA A 1 490 ? 157.811 130.302 193.065 1.00 60.62  ?  479 ALA A CB  1 
ATOM   2501 N N   . LEU A 1 491 ? 160.311 130.792 195.315 1.00 66.92  ?  480 LEU A N   1 
ATOM   2502 C CA  . LEU A 1 491 ? 161.712 130.485 195.603 1.00 66.92  ?  480 LEU A CA  1 
ATOM   2503 C C   . LEU A 1 491 ? 162.173 130.977 196.979 1.00 66.92  ?  480 LEU A C   1 
ATOM   2504 O O   . LEU A 1 491 ? 161.431 131.644 197.698 1.00 66.92  ?  480 LEU A O   1 
ATOM   2505 C CB  . LEU A 1 491 ? 162.633 131.041 194.514 1.00 66.92  ?  480 LEU A CB  1 
ATOM   2506 C CG  . LEU A 1 491 ? 162.072 131.141 193.095 1.00 66.92  ?  480 LEU A CG  1 
ATOM   2507 C CD1 . LEU A 1 491 ? 161.866 132.598 192.715 1.00 66.92  ?  480 LEU A CD1 1 
ATOM   2508 C CD2 . LEU A 1 491 ? 162.989 130.457 192.093 1.00 66.92  ?  480 LEU A CD2 1 
ATOM   2509 N N   . PRO A 1 492 ? 163.464 130.611 197.337 1.00 72.12  ?  481 PRO A N   1 
ATOM   2510 C CA  . PRO A 1 492 ? 163.889 131.081 198.670 1.00 72.12  ?  481 PRO A CA  1 
ATOM   2511 C C   . PRO A 1 492 ? 163.829 132.596 198.882 1.00 72.12  ?  481 PRO A C   1 
ATOM   2512 O O   . PRO A 1 492 ? 163.324 133.322 198.031 1.00 72.12  ?  481 PRO A O   1 
ATOM   2513 C CB  . PRO A 1 492 ? 165.346 130.613 198.772 1.00 72.12  ?  481 PRO A CB  1 
ATOM   2514 C CG  . PRO A 1 492 ? 165.406 129.393 197.937 1.00 72.12  ?  481 PRO A CG  1 
ATOM   2515 C CD  . PRO A 1 492 ? 164.621 129.802 196.738 1.00 72.12  ?  481 PRO A CD  1 
ATOM   2516 N N   . GLY A 1 493 ? 164.352 133.041 200.026 1.00 71.36  ?  482 GLY A N   1 
ATOM   2517 C CA  . GLY A 1 493 ? 164.383 134.445 200.413 1.00 71.36  ?  482 GLY A CA  1 
ATOM   2518 C C   . GLY A 1 493 ? 164.517 135.426 199.270 1.00 71.36  ?  482 GLY A C   1 
ATOM   2519 O O   . GLY A 1 493 ? 165.126 135.112 198.246 1.00 71.36  ?  482 GLY A O   1 
ATOM   2520 N N   . GLN A 1 494 ? 163.959 136.625 199.440 1.00 68.29  ?  483 GLN A N   1 
ATOM   2521 C CA  . GLN A 1 494 ? 164.014 137.608 198.370 1.00 68.29  ?  483 GLN A CA  1 
ATOM   2522 C C   . GLN A 1 494 ? 163.038 138.725 198.714 1.00 68.29  ?  483 GLN A C   1 
ATOM   2523 O O   . GLN A 1 494 ? 162.020 138.467 199.369 1.00 68.29  ?  483 GLN A O   1 
ATOM   2524 C CB  . GLN A 1 494 ? 163.647 136.945 197.041 1.00 68.29  ?  483 GLN A CB  1 
ATOM   2525 C CG  . GLN A 1 494 ? 164.176 137.611 195.808 1.00 68.29  ?  483 GLN A CG  1 
ATOM   2526 C CD  . GLN A 1 494 ? 163.764 136.876 194.572 1.00 68.29  ?  483 GLN A CD  1 
ATOM   2527 O OE1 . GLN A 1 494 ? 162.895 136.015 194.617 1.00 68.29  ?  483 GLN A OE1 1 
ATOM   2528 N NE2 . GLN A 1 494 ? 164.407 137.178 193.465 1.00 68.29  ?  483 GLN A NE2 1 
ATOM   2529 N N   . PRO A 1 495 ? 163.309 139.972 198.326 1.00 69.46  ?  484 PRO A N   1 
ATOM   2530 C CA  . PRO A 1 495 ? 162.282 141.016 198.450 1.00 69.46  ?  484 PRO A CA  1 
ATOM   2531 C C   . PRO A 1 495 ? 161.146 140.743 197.475 1.00 69.46  ?  484 PRO A C   1 
ATOM   2532 O O   . PRO A 1 495 ? 161.368 140.618 196.272 1.00 69.46  ?  484 PRO A O   1 
ATOM   2533 C CB  . PRO A 1 495 ? 163.037 142.304 198.103 1.00 69.46  ?  484 PRO A CB  1 
ATOM   2534 C CG  . PRO A 1 495 ? 164.232 141.856 197.361 1.00 69.46  ?  484 PRO A CG  1 
ATOM   2535 C CD  . PRO A 1 495 ? 164.608 140.535 197.929 1.00 69.46  ?  484 PRO A CD  1 
ATOM   2536 N N   . MET A 1 496 ? 159.927 140.628 198.000 1.00 70.11  ?  485 MET A N   1 
ATOM   2537 C CA  . MET A 1 496 ? 158.807 140.310 197.127 1.00 70.11  ?  485 MET A CA  1 
ATOM   2538 C C   . MET A 1 496 ? 158.279 141.537 196.400 1.00 70.11  ?  485 MET A C   1 
ATOM   2539 O O   . MET A 1 496 ? 157.425 141.398 195.520 1.00 70.11  ?  485 MET A O   1 
ATOM   2540 C CB  . MET A 1 496 ? 157.677 139.635 197.912 1.00 70.11  ?  485 MET A CB  1 
ATOM   2541 C CG  . MET A 1 496 ? 156.961 140.517 198.920 1.00 70.11  ?  485 MET A CG  1 
ATOM   2542 S SD  . MET A 1 496 ? 155.634 139.597 199.725 1.00 70.11  ?  485 MET A SD  1 
ATOM   2543 C CE  . MET A 1 496 ? 154.959 140.820 200.835 1.00 70.11  ?  485 MET A CE  1 
ATOM   2544 N N   . GLU A 1 497 ? 158.758 142.732 196.753 1.00 61.67  ?  486 GLU A N   1 
ATOM   2545 C CA  . GLU A 1 497 ? 158.417 143.921 195.981 1.00 61.67  ?  486 GLU A CA  1 
ATOM   2546 C C   . GLU A 1 497 ? 159.188 143.972 194.674 1.00 61.67  ?  486 GLU A C   1 
ATOM   2547 O O   . GLU A 1 497 ? 158.792 144.689 193.752 1.00 61.67  ?  486 GLU A O   1 
ATOM   2548 C CB  . GLU A 1 497 ? 158.662 145.183 196.813 1.00 61.67  ?  486 GLU A CB  1 
ATOM   2549 C CG  . GLU A 1 497 ? 160.101 145.402 197.284 1.00 61.67  ?  486 GLU A CG  1 
ATOM   2550 C CD  . GLU A 1 497 ? 160.913 146.316 196.378 1.00 61.67  ?  486 GLU A CD  1 
ATOM   2551 O OE1 . GLU A 1 497 ? 160.313 147.102 195.619 1.00 61.67  ?  486 GLU A OE1 1 
ATOM   2552 O OE2 . GLU A 1 497 ? 162.158 146.258 196.433 1.00 61.67  -1 486 GLU A OE2 1 
ATOM   2553 N N   . ALA A 1 498 ? 160.287 143.229 194.577 1.00 54.47  ?  487 ALA A N   1 
ATOM   2554 C CA  . ALA A 1 498 ? 161.134 143.220 193.386 1.00 54.47  ?  487 ALA A CA  1 
ATOM   2555 C C   . ALA A 1 498 ? 161.818 141.870 193.251 1.00 54.47  ?  487 ALA A C   1 
ATOM   2556 O O   . ALA A 1 498 ? 162.976 141.698 193.646 1.00 54.47  ?  487 ALA A O   1 
ATOM   2557 C CB  . ALA A 1 498 ? 162.165 144.346 193.444 1.00 54.47  ?  487 ALA A CB  1 
ATOM   2558 N N   . PRO A 1 499 ? 161.133 140.882 192.684 1.00 48.05  ?  488 PRO A N   1 
ATOM   2559 C CA  . PRO A 1 499 ? 161.785 139.608 192.386 1.00 48.05  ?  488 PRO A CA  1 
ATOM   2560 C C   . PRO A 1 499 ? 162.625 139.731 191.131 1.00 48.05  ?  488 PRO A C   1 
ATOM   2561 O O   . PRO A 1 499 ? 162.612 140.748 190.445 1.00 48.05  ?  488 PRO A O   1 
ATOM   2562 C CB  . PRO A 1 499 ? 160.610 138.660 192.181 1.00 48.05  ?  488 PRO A CB  1 
ATOM   2563 C CG  . PRO A 1 499 ? 159.558 139.520 191.641 1.00 48.05  ?  488 PRO A CG  1 
ATOM   2564 C CD  . PRO A 1 499 ? 159.719 140.869 192.278 1.00 48.05  ?  488 PRO A CD  1 
ATOM   2565 N N   . VAL A 1 500 ? 163.373 138.689 190.826 1.00 42.77  ?  489 VAL A N   1 
ATOM   2566 C CA  . VAL A 1 500 ? 164.219 138.712 189.645 1.00 42.77  ?  489 VAL A CA  1 
ATOM   2567 C C   . VAL A 1 500 ? 163.484 138.044 188.498 1.00 42.77  ?  489 VAL A C   1 
ATOM   2568 O O   . VAL A 1 500 ? 162.736 137.084 188.695 1.00 42.77  ?  489 VAL A O   1 
ATOM   2569 C CB  . VAL A 1 500 ? 165.588 138.056 189.911 1.00 42.77  ?  489 VAL A CB  1 
ATOM   2570 C CG1 . VAL A 1 500 ? 166.337 138.841 190.955 1.00 42.77  ?  489 VAL A CG1 1 
ATOM   2571 C CG2 . VAL A 1 500 ? 165.465 136.618 190.323 1.00 42.77  ?  489 VAL A CG2 1 
ATOM   2572 N N   . MET A 1 501 ? 163.657 138.584 187.303 1.00 37.94  ?  490 MET A N   1 
ATOM   2573 C CA  . MET A 1 501 ? 163.054 137.989 186.128 1.00 37.94  ?  490 MET A CA  1 
ATOM   2574 C C   . MET A 1 501 ? 163.852 136.758 185.745 1.00 37.94  ?  490 MET A C   1 
ATOM   2575 O O   . MET A 1 501 ? 165.081 136.764 185.818 1.00 37.94  ?  490 MET A O   1 
ATOM   2576 C CB  . MET A 1 501 ? 163.027 139.000 184.989 1.00 37.94  ?  490 MET A CB  1 
ATOM   2577 C CG  . MET A 1 501 ? 162.228 138.580 183.787 1.00 37.94  ?  490 MET A CG  1 
ATOM   2578 S SD  . MET A 1 501 ? 160.504 138.304 184.126 1.00 37.94  ?  490 MET A SD  1 
ATOM   2579 C CE  . MET A 1 501 ? 159.892 138.053 182.477 1.00 37.94  ?  490 MET A CE  1 
ATOM   2580 N N   . LEU A 1 502 ? 163.161 135.692 185.362 1.00 42.67  ?  491 LEU A N   1 
ATOM   2581 C CA  . LEU A 1 502 ? 163.802 134.422 185.032 1.00 42.67  ?  491 LEU A CA  1 
ATOM   2582 C C   . LEU A 1 502 ? 163.872 134.300 183.518 1.00 42.67  ?  491 LEU A C   1 
ATOM   2583 O O   . LEU A 1 502 ? 163.008 133.702 182.883 1.00 42.67  ?  491 LEU A O   1 
ATOM   2584 C CB  . LEU A 1 502 ? 163.050 133.260 185.661 1.00 42.67  ?  491 LEU A CB  1 
ATOM   2585 C CG  . LEU A 1 502 ? 162.829 133.384 187.165 1.00 42.67  ?  491 LEU A CG  1 
ATOM   2586 C CD1 . LEU A 1 502 ? 161.944 132.277 187.655 1.00 42.67  ?  491 LEU A CD1 1 
ATOM   2587 C CD2 . LEU A 1 502 ? 164.137 133.395 187.913 1.00 42.67  ?  491 LEU A CD2 1 
ATOM   2588 N N   . TRP A 1 503 ? 164.926 134.875 182.943 1.00 45.44  ?  492 TRP A N   1 
ATOM   2589 C CA  . TRP A 1 503 ? 165.144 134.783 181.504 1.00 45.44  ?  492 TRP A CA  1 
ATOM   2590 C C   . TRP A 1 503 ? 165.506 133.367 181.092 1.00 45.44  ?  492 TRP A C   1 
ATOM   2591 O O   . TRP A 1 503 ? 164.830 132.758 180.256 1.00 45.44  ?  492 TRP A O   1 
ATOM   2592 C CB  . TRP A 1 503 ? 166.248 135.744 181.084 1.00 45.44  ?  492 TRP A CB  1 
ATOM   2593 C CG  . TRP A 1 503 ? 165.931 137.153 181.335 1.00 45.44  ?  492 TRP A CG  1 
ATOM   2594 C CD1 . TRP A 1 503 ? 166.531 137.975 182.224 1.00 45.44  ?  492 TRP A CD1 1 
ATOM   2595 C CD2 . TRP A 1 503 ? 164.929 137.926 180.681 1.00 45.44  ?  492 TRP A CD2 1 
ATOM   2596 N NE1 . TRP A 1 503 ? 165.971 139.217 182.169 1.00 45.44  ?  492 TRP A NE1 1 
ATOM   2597 C CE2 . TRP A 1 503 ? 164.979 139.210 181.229 1.00 45.44  ?  492 TRP A CE2 1 
ATOM   2598 C CE3 . TRP A 1 503 ? 163.989 137.652 179.685 1.00 45.44  ?  492 TRP A CE3 1 
ATOM   2599 C CZ2 . TRP A 1 503 ? 164.137 140.217 180.816 1.00 45.44  ?  492 TRP A CZ2 1 
ATOM   2600 C CZ3 . TRP A 1 503 ? 163.159 138.645 179.281 1.00 45.44  ?  492 TRP A CZ3 1 
ATOM   2601 C CH2 . TRP A 1 503 ? 163.235 139.915 179.840 1.00 45.44  ?  492 TRP A CH2 1 
ATOM   2602 N N   . ASP A 1 504 ? 166.570 132.830 181.683 1.00 62.73  ?  493 ASP A N   1 
ATOM   2603 C CA  . ASP A 1 504 ? 167.076 131.494 181.402 1.00 62.73  ?  493 ASP A CA  1 
ATOM   2604 C C   . ASP A 1 504 ? 167.143 130.696 182.697 1.00 62.73  ?  493 ASP A C   1 
ATOM   2605 O O   . ASP A 1 504 ? 166.586 131.129 183.709 1.00 62.73  ?  493 ASP A O   1 
ATOM   2606 C CB  . ASP A 1 504 ? 168.436 131.592 180.706 1.00 62.73  ?  493 ASP A CB  1 
ATOM   2607 C CG  . ASP A 1 504 ? 169.418 132.490 181.450 1.00 62.73  ?  493 ASP A CG  1 
ATOM   2608 O OD1 . ASP A 1 504 ? 169.055 133.061 182.498 1.00 62.73  ?  493 ASP A OD1 1 
ATOM   2609 O OD2 . ASP A 1 504 ? 170.556 132.648 180.969 1.00 62.73  -1 493 ASP A OD2 1 
ATOM   2610 N N   . GLU A 1 505 ? 167.800 129.532 182.689 1.00 67.62  ?  494 GLU A N   1 
ATOM   2611 C CA  . GLU A 1 505 ? 167.899 128.744 183.914 1.00 67.62  ?  494 GLU A CA  1 
ATOM   2612 C C   . GLU A 1 505 ? 169.085 129.117 184.780 1.00 67.62  ?  494 GLU A C   1 
ATOM   2613 O O   . GLU A 1 505 ? 169.219 128.570 185.877 1.00 67.62  ?  494 GLU A O   1 
ATOM   2614 C CB  . GLU A 1 505 ? 167.959 127.251 183.610 1.00 67.62  ?  494 GLU A CB  1 
ATOM   2615 C CG  . GLU A 1 505 ? 166.634 126.639 183.259 1.00 67.62  ?  494 GLU A CG  1 
ATOM   2616 C CD  . GLU A 1 505 ? 166.301 126.766 181.800 1.00 67.62  ?  494 GLU A CD  1 
ATOM   2617 O OE1 . GLU A 1 505 ? 167.133 127.296 181.039 1.00 67.62  ?  494 GLU A OE1 1 
ATOM   2618 O OE2 . GLU A 1 505 ? 165.209 126.317 181.404 1.00 67.62  -1 494 GLU A OE2 1 
ATOM   2619 N N   . SER A 1 506 ? 169.957 130.005 184.321 1.00 70.57  ?  495 SER A N   1 
ATOM   2620 C CA  . SER A 1 506 ? 170.995 130.556 185.178 1.00 70.57  ?  495 SER A CA  1 
ATOM   2621 C C   . SER A 1 506 ? 170.705 131.989 185.583 1.00 70.57  ?  495 SER A C   1 
ATOM   2622 O O   . SER A 1 506 ? 171.640 132.754 185.842 1.00 70.57  ?  495 SER A O   1 
ATOM   2623 C CB  . SER A 1 506 ? 172.361 130.469 184.498 1.00 70.57  ?  495 SER A CB  1 
ATOM   2624 O OG  . SER A 1 506 ? 172.840 129.135 184.463 1.00 70.57  ?  495 SER A OG  1 
ATOM   2625 N N   . SER A 1 507 ? 169.430 132.373 185.628 1.00 67.85  ?  496 SER A N   1 
ATOM   2626 C CA  . SER A 1 507 ? 169.077 133.743 185.966 1.00 67.85  ?  496 SER A CA  1 
ATOM   2627 C C   . SER A 1 507 ? 169.218 134.013 187.455 1.00 67.85  ?  496 SER A C   1 
ATOM   2628 O O   . SER A 1 507 ? 169.571 135.129 187.848 1.00 67.85  ?  496 SER A O   1 
ATOM   2629 C CB  . SER A 1 507 ? 167.656 134.035 185.504 1.00 67.85  ?  496 SER A CB  1 
ATOM   2630 O OG  . SER A 1 507 ? 167.524 133.749 184.125 1.00 67.85  ?  496 SER A OG  1 
ATOM   2631 N N   . PHE A 1 508 ? 168.952 133.014 188.288 1.00 81.52  ?  497 PHE A N   1 
ATOM   2632 C CA  . PHE A 1 508 ? 169.140 133.140 189.727 1.00 81.52  ?  497 PHE A CA  1 
ATOM   2633 C C   . PHE A 1 508 ? 170.400 132.385 190.122 1.00 81.52  ?  497 PHE A C   1 
ATOM   2634 O O   . PHE A 1 508 ? 170.387 131.145 190.185 1.00 81.52  ?  497 PHE A O   1 
ATOM   2635 C CB  . PHE A 1 508 ? 167.928 132.603 190.489 1.00 81.52  ?  497 PHE A CB  1 
ATOM   2636 C CG  . PHE A 1 508 ? 167.875 133.055 191.910 1.00 81.52  ?  497 PHE A CG  1 
ATOM   2637 C CD1 . PHE A 1 508 ? 168.475 134.246 192.288 1.00 81.52  ?  497 PHE A CD1 1 
ATOM   2638 C CD2 . PHE A 1 508 ? 167.230 132.302 192.870 1.00 81.52  ?  497 PHE A CD2 1 
ATOM   2639 C CE1 . PHE A 1 508 ? 168.435 134.679 193.593 1.00 81.52  ?  497 PHE A CE1 1 
ATOM   2640 C CE2 . PHE A 1 508 ? 167.191 132.728 194.187 1.00 81.52  ?  497 PHE A CE2 1 
ATOM   2641 C CZ  . PHE A 1 508 ? 167.790 133.922 194.544 1.00 81.52  ?  497 PHE A CZ  1 
ATOM   2642 N N   . PRO A 1 509 ? 171.509 133.076 190.387 1.00 89.15  ?  498 PRO A N   1 
ATOM   2643 C CA  . PRO A 1 509 ? 172.765 132.382 190.698 1.00 89.15  ?  498 PRO A CA  1 
ATOM   2644 C C   . PRO A 1 509 ? 172.751 131.706 192.061 1.00 89.15  ?  498 PRO A C   1 
ATOM   2645 O O   . PRO A 1 509 ? 173.286 130.605 192.217 1.00 89.15  ?  498 PRO A O   1 
ATOM   2646 C CB  . PRO A 1 509 ? 173.805 133.508 190.639 1.00 89.15  ?  498 PRO A CB  1 
ATOM   2647 C CG  . PRO A 1 509 ? 173.038 134.758 190.902 1.00 89.15  ?  498 PRO A CG  1 
ATOM   2648 C CD  . PRO A 1 509 ? 171.661 134.542 190.375 1.00 89.15  ?  498 PRO A CD  1 
ATOM   2649 N N   . ASP A 1 510 ? 172.138 132.337 193.064 1.00 89.98  ?  499 ASP A N   1 
ATOM   2650 C CA  . ASP A 1 510 ? 172.071 131.765 194.421 1.00 89.98  ?  499 ASP A CA  1 
ATOM   2651 C C   . ASP A 1 510 ? 171.102 130.582 194.515 1.00 89.98  ?  499 ASP A C   1 
ATOM   2652 O O   . ASP A 1 510 ? 170.137 130.525 193.756 1.00 89.98  ?  499 ASP A O   1 
ATOM   2653 C CB  . ASP A 1 510 ? 171.719 132.850 195.434 1.00 89.98  ?  499 ASP A CB  1 
ATOM   2654 C CG  . ASP A 1 510 ? 172.669 134.021 195.365 1.00 89.98  ?  499 ASP A CG  1 
ATOM   2655 O OD1 . ASP A 1 510 ? 173.375 134.136 194.343 1.00 89.98  ?  499 ASP A OD1 1 
ATOM   2656 O OD2 . ASP A 1 510 ? 172.715 134.818 196.324 1.00 89.98  -1 499 ASP A OD2 1 
ATOM   2657 N N   . ILE A 1 511 ? 171.358 129.625 195.424 1.00 88.06  ?  500 ILE A N   1 
ATOM   2658 C CA  . ILE A 1 511 ? 170.536 128.395 195.575 1.00 88.06  ?  500 ILE A CA  1 
ATOM   2659 C C   . ILE A 1 511 ? 170.406 127.864 194.154 1.00 88.06  ?  500 ILE A C   1 
ATOM   2660 O O   . ILE A 1 511 ? 169.403 128.066 193.473 1.00 88.06  ?  500 ILE A O   1 
ATOM   2661 C CB  . ILE A 1 511 ? 169.179 128.644 196.269 1.00 88.06  ?  500 ILE A CB  1 
ATOM   2662 C CG1 . ILE A 1 511 ? 168.262 129.530 195.428 1.00 88.06  ?  500 ILE A CG1 1 
ATOM   2663 C CG2 . ILE A 1 511 ? 169.392 129.269 197.639 1.00 88.06  ?  500 ILE A CG2 1 
ATOM   2664 C CD1 . ILE A 1 511 ? 167.135 128.769 194.765 1.00 88.06  ?  500 ILE A CD1 1 
ATOM   2665 N N   . PRO A 1 512 ? 171.470 127.228 193.692 1.00 86.22  ?  501 PRO A N   1 
ATOM   2666 C CA  . PRO A 1 512 ? 171.536 126.865 192.272 1.00 86.22  ?  501 PRO A CA  1 
ATOM   2667 C C   . PRO A 1 512 ? 170.775 125.588 191.953 1.00 86.22  ?  501 PRO A C   1 
ATOM   2668 O O   . PRO A 1 512 ? 170.801 124.615 192.710 1.00 86.22  ?  501 PRO A O   1 
ATOM   2669 C CB  . PRO A 1 512 ? 173.038 126.688 192.031 1.00 86.22  ?  501 PRO A CB  1 
ATOM   2670 C CG  . PRO A 1 512 ? 173.569 126.232 193.362 1.00 86.22  ?  501 PRO A CG  1 
ATOM   2671 C CD  . PRO A 1 512 ? 172.681 126.824 194.429 1.00 86.22  ?  501 PRO A CD  1 
ATOM   2672 N N   . GLY A 1 513 ? 170.087 125.610 190.812 1.00 80.60  ?  502 GLY A N   1 
ATOM   2673 C CA  . GLY A 1 513 ? 169.255 124.511 190.374 1.00 80.60  ?  502 GLY A CA  1 
ATOM   2674 C C   . GLY A 1 513 ? 167.811 124.580 190.815 1.00 80.60  ?  502 GLY A C   1 
ATOM   2675 O O   . GLY A 1 513 ? 167.039 123.675 190.481 1.00 80.60  ?  502 GLY A O   1 
ATOM   2676 N N   . ALA A 1 514 ? 167.418 125.625 191.541 1.00 75.53  ?  503 ALA A N   1 
ATOM   2677 C CA  . ALA A 1 514 ? 166.057 125.739 192.054 1.00 75.53  ?  503 ALA A CA  1 
ATOM   2678 C C   . ALA A 1 514 ? 165.056 126.210 191.007 1.00 75.53  ?  503 ALA A C   1 
ATOM   2679 O O   . ALA A 1 514 ? 163.846 126.090 191.226 1.00 75.53  ?  503 ALA A O   1 
ATOM   2680 C CB  . ALA A 1 514 ? 166.024 126.690 193.254 1.00 75.53  ?  503 ALA A CB  1 
ATOM   2681 N N   . VAL A 1 515 ? 165.519 126.757 189.893 1.00 70.00  ?  504 VAL A N   1 
ATOM   2682 C CA  . VAL A 1 515 ? 164.616 127.210 188.842 1.00 70.00  ?  504 VAL A CA  1 
ATOM   2683 C C   . VAL A 1 515 ? 164.487 126.123 187.785 1.00 70.00  ?  504 VAL A C   1 
ATOM   2684 O O   . VAL A 1 515 ? 165.487 125.686 187.207 1.00 70.00  ?  504 VAL A O   1 
ATOM   2685 C CB  . VAL A 1 515 ? 165.124 128.526 188.228 1.00 70.00  ?  504 VAL A CB  1 
ATOM   2686 C CG1 . VAL A 1 515 ? 164.260 128.924 187.079 1.00 70.00  ?  504 VAL A CG1 1 
ATOM   2687 C CG2 . VAL A 1 515 ? 165.136 129.626 189.258 1.00 70.00  ?  504 VAL A CG2 1 
ATOM   2688 N N   . SER A 1 516 ? 163.261 125.693 187.505 1.00 64.48  ?  505 SER A N   1 
ATOM   2689 C CA  . SER A 1 516 ? 163.030 124.696 186.473 1.00 64.48  ?  505 SER A CA  1 
ATOM   2690 C C   . SER A 1 516 ? 162.911 125.378 185.112 1.00 64.48  ?  505 SER A C   1 
ATOM   2691 O O   . SER A 1 516 ? 163.248 126.549 184.950 1.00 64.48  ?  505 SER A O   1 
ATOM   2692 C CB  . SER A 1 516 ? 161.794 123.857 186.792 1.00 64.48  ?  505 SER A CB  1 
ATOM   2693 O OG  . SER A 1 516 ? 160.604 124.585 186.599 1.00 64.48  ?  505 SER A OG  1 
ATOM   2694 N N   . ALA A 1 517 ? 162.442 124.631 184.114 1.00 63.11  ?  506 ALA A N   1 
ATOM   2695 C CA  . ALA A 1 517 ? 162.472 125.135 182.744 1.00 63.11  ?  506 ALA A CA  1 
ATOM   2696 C C   . ALA A 1 517 ? 161.154 125.780 182.340 1.00 63.11  ?  506 ALA A C   1 
ATOM   2697 O O   . ALA A 1 517 ? 161.140 126.721 181.539 1.00 63.11  ?  506 ALA A O   1 
ATOM   2698 C CB  . ALA A 1 517 ? 162.822 124.014 181.772 1.00 63.11  ?  506 ALA A CB  1 
ATOM   2699 N N   . ASN A 1 518 ? 160.043 125.289 182.878 1.00 68.88  ?  507 ASN A N   1 
ATOM   2700 C CA  . ASN A 1 518 ? 158.733 125.877 182.643 1.00 68.88  ?  507 ASN A CA  1 
ATOM   2701 C C   . ASN A 1 518 ? 158.449 127.064 183.547 1.00 68.88  ?  507 ASN A C   1 
ATOM   2702 O O   . ASN A 1 518 ? 157.298 127.490 183.626 1.00 68.88  ?  507 ASN A O   1 
ATOM   2703 C CB  . ASN A 1 518 ? 157.652 124.832 182.857 1.00 68.88  ?  507 ASN A CB  1 
ATOM   2704 C CG  . ASN A 1 518 ? 157.811 124.130 184.163 1.00 68.88  ?  507 ASN A CG  1 
ATOM   2705 O OD1 . ASN A 1 518 ? 158.923 123.840 184.591 1.00 68.88  ?  507 ASN A OD1 1 
ATOM   2706 N ND2 . ASN A 1 518 ? 156.708 123.876 184.825 1.00 68.88  ?  507 ASN A ND2 1 
ATOM   2707 N N   . MET A 1 519 ? 159.452 127.569 184.259 1.00 57.74  ?  508 MET A N   1 
ATOM   2708 C CA  . MET A 1 519 ? 159.350 128.781 185.050 1.00 57.74  ?  508 MET A CA  1 
ATOM   2709 C C   . MET A 1 519 ? 160.076 129.953 184.408 1.00 57.74  ?  508 MET A C   1 
ATOM   2710 O O   . MET A 1 519 ? 160.176 131.017 185.021 1.00 57.74  ?  508 MET A O   1 
ATOM   2711 C CB  . MET A 1 519 ? 159.909 128.538 186.449 1.00 57.74  ?  508 MET A CB  1 
ATOM   2712 C CG  . MET A 1 519 ? 158.997 127.768 187.348 1.00 57.74  ?  508 MET A CG  1 
ATOM   2713 S SD  . MET A 1 519 ? 159.789 127.277 188.880 1.00 57.74  ?  508 MET A SD  1 
ATOM   2714 C CE  . MET A 1 519 ? 160.673 128.761 189.308 1.00 57.74  ?  508 MET A CE  1 
ATOM   2715 N N   . THR A 1 520 ? 160.597 129.782 183.202 1.00 51.60  ?  509 THR A N   1 
ATOM   2716 C CA  . THR A 1 520 ? 161.490 130.744 182.583 1.00 51.60  ?  509 THR A CA  1 
ATOM   2717 C C   . THR A 1 520 ? 160.873 131.292 181.307 1.00 51.60  ?  509 THR A C   1 
ATOM   2718 O O   . THR A 1 520 ? 159.905 130.748 180.780 1.00 51.60  ?  509 THR A O   1 
ATOM   2719 C CB  . THR A 1 520 ? 162.846 130.106 182.267 1.00 51.60  ?  509 THR A CB  1 
ATOM   2720 O OG1 . THR A 1 520 ? 162.660 129.044 181.327 1.00 51.60  ?  509 THR A OG1 1 
ATOM   2721 C CG2 . THR A 1 520 ? 163.488 129.560 183.511 1.00 51.60  ?  509 THR A CG2 1 
ATOM   2722 N N   . VAL A 1 521 ? 161.460 132.380 180.809 1.00 45.88  ?  510 VAL A N   1 
ATOM   2723 C CA  . VAL A 1 521 ? 161.003 132.955 179.550 1.00 45.88  ?  510 VAL A CA  1 
ATOM   2724 C C   . VAL A 1 521 ? 161.337 132.023 178.402 1.00 45.88  ?  510 VAL A C   1 
ATOM   2725 O O   . VAL A 1 521 ? 160.478 131.701 177.571 1.00 45.88  ?  510 VAL A O   1 
ATOM   2726 C CB  . VAL A 1 521 ? 161.627 134.346 179.329 1.00 45.88  ?  510 VAL A CB  1 
ATOM   2727 C CG1 . VAL A 1 521 ? 161.302 134.855 177.953 1.00 45.88  ?  510 VAL A CG1 1 
ATOM   2728 C CG2 . VAL A 1 521 ? 161.130 135.308 180.347 1.00 45.88  ?  510 VAL A CG2 1 
ATOM   2729 N N   . LYS A 1 522 ? 162.587 131.549 178.366 1.00 51.08  ?  511 LYS A N   1 
ATOM   2730 C CA  . LYS A 1 522 ? 163.074 130.700 177.287 1.00 51.08  ?  511 LYS A CA  1 
ATOM   2731 C C   . LYS A 1 522 ? 162.357 129.362 177.214 1.00 51.08  ?  511 LYS A C   1 
ATOM   2732 O O   . LYS A 1 522 ? 161.995 128.937 176.119 1.00 51.08  ?  511 LYS A O   1 
ATOM   2733 C CB  . LYS A 1 522 ? 164.573 130.466 177.452 1.00 51.08  ?  511 LYS A CB  1 
ATOM   2734 C CG  . LYS A 1 522 ? 165.181 129.566 176.393 1.00 51.08  ?  511 LYS A CG  1 
ATOM   2735 C CD  . LYS A 1 522 ? 166.684 129.486 176.526 1.00 51.08  ?  511 LYS A CD  1 
ATOM   2736 C CE  . LYS A 1 522 ? 167.049 128.818 177.836 1.00 51.08  ?  511 LYS A CE  1 
ATOM   2737 N NZ  . LYS A 1 522 ? 166.542 127.415 177.920 1.00 51.08  1  511 LYS A NZ  1 
ATOM   2738 N N   . GLY A 1 523 ? 162.105 128.714 178.350 1.00 51.17  ?  512 GLY A N   1 
ATOM   2739 C CA  . GLY A 1 523 ? 161.450 127.426 178.342 1.00 51.17  ?  512 GLY A CA  1 
ATOM   2740 C C   . GLY A 1 523 ? 159.954 127.481 178.166 1.00 51.17  ?  512 GLY A C   1 
ATOM   2741 O O   . GLY A 1 523 ? 159.331 126.439 177.963 1.00 51.17  ?  512 GLY A O   1 
ATOM   2742 N N   . GLN A 1 524 ? 159.356 128.668 178.262 1.00 45.64  ?  513 GLN A N   1 
ATOM   2743 C CA  . GLN A 1 524 ? 157.922 128.833 178.053 1.00 45.64  ?  513 GLN A CA  1 
ATOM   2744 C C   . GLN A 1 524 ? 157.565 129.284 176.650 1.00 45.64  ?  513 GLN A C   1 
ATOM   2745 O O   . GLN A 1 524 ? 156.384 129.254 176.297 1.00 45.64  ?  513 GLN A O   1 
ATOM   2746 C CB  . GLN A 1 524 ? 157.342 129.851 179.035 1.00 45.64  ?  513 GLN A CB  1 
ATOM   2747 C CG  . GLN A 1 524 ? 156.961 129.303 180.381 1.00 45.64  ?  513 GLN A CG  1 
ATOM   2748 C CD  . GLN A 1 524 ? 155.876 130.122 181.007 1.00 45.64  ?  513 GLN A CD  1 
ATOM   2749 O OE1 . GLN A 1 524 ? 155.783 131.311 180.750 1.00 45.64  ?  513 GLN A OE1 1 
ATOM   2750 N NE2 . GLN A 1 524 ? 155.033 129.494 181.811 1.00 45.64  ?  513 GLN A NE2 1 
ATOM   2751 N N   . SER A 1 525 ? 158.542 129.713 175.855 1.00 49.78  ?  514 SER A N   1 
ATOM   2752 C CA  . SER A 1 525 ? 158.242 130.165 174.505 1.00 49.78  ?  514 SER A CA  1 
ATOM   2753 C C   . SER A 1 525 ? 157.973 129.012 173.543 1.00 49.78  ?  514 SER A C   1 
ATOM   2754 O O   . SER A 1 525 ? 157.431 129.244 172.457 1.00 49.78  ?  514 SER A O   1 
ATOM   2755 C CB  . SER A 1 525 ? 159.386 131.024 173.979 1.00 49.78  ?  514 SER A CB  1 
ATOM   2756 O OG  . SER A 1 525 ? 159.841 131.910 174.976 1.00 49.78  ?  514 SER A OG  1 
ATOM   2757 N N   . GLU A 1 526 ? 158.357 127.787 173.897 1.00 54.55  ?  515 GLU A N   1 
ATOM   2758 C CA  . GLU A 1 526 ? 158.146 126.642 173.023 1.00 54.55  ?  515 GLU A CA  1 
ATOM   2759 C C   . GLU A 1 526 ? 156.893 125.868 173.359 1.00 54.55  ?  515 GLU A C   1 
ATOM   2760 O O   . GLU A 1 526 ? 156.298 125.269 172.461 1.00 54.55  ?  515 GLU A O   1 
ATOM   2761 C CB  . GLU A 1 526 ? 159.326 125.669 173.085 1.00 54.55  ?  515 GLU A CB  1 
ATOM   2762 C CG  . GLU A 1 526 ? 160.648 126.252 172.678 1.00 54.55  ?  515 GLU A CG  1 
ATOM   2763 C CD  . GLU A 1 526 ? 161.366 126.824 173.859 1.00 54.55  ?  515 GLU A CD  1 
ATOM   2764 O OE1 . GLU A 1 526 ? 160.833 126.673 174.979 1.00 54.55  ?  515 GLU A OE1 1 
ATOM   2765 O OE2 . GLU A 1 526 ? 162.452 127.403 173.674 1.00 54.55  -1 515 GLU A OE2 1 
ATOM   2766 N N   . ASP A 1 527 ? 156.513 125.837 174.628 1.00 44.00  ?  516 ASP A N   1 
ATOM   2767 C CA  . ASP A 1 527 ? 155.291 125.162 175.029 1.00 44.00  ?  516 ASP A CA  1 
ATOM   2768 C C   . ASP A 1 527 ? 154.096 125.932 174.480 1.00 44.00  ?  516 ASP A C   1 
ATOM   2769 O O   . ASP A 1 527 ? 153.917 127.105 174.816 1.00 44.00  ?  516 ASP A O   1 
ATOM   2770 C CB  . ASP A 1 527 ? 155.236 125.066 176.553 1.00 44.00  ?  516 ASP A CB  1 
ATOM   2771 C CG  . ASP A 1 527 ? 154.204 124.072 177.052 1.00 44.00  ?  516 ASP A CG  1 
ATOM   2772 O OD1 . ASP A 1 527 ? 153.513 123.449 176.230 1.00 44.00  ?  516 ASP A OD1 1 
ATOM   2773 O OD2 . ASP A 1 527 ? 154.072 123.919 178.280 1.00 44.00  -1 516 ASP A OD2 1 
ATOM   2774 N N   . PRO A 1 528 ? 153.268 125.327 173.625 1.00 45.17  ?  517 PRO A N   1 
ATOM   2775 C CA  . PRO A 1 528 ? 152.124 126.068 173.085 1.00 45.17  ?  517 PRO A CA  1 
ATOM   2776 C C   . PRO A 1 528 ? 150.940 126.096 174.024 1.00 45.17  ?  517 PRO A C   1 
ATOM   2777 O O   . PRO A 1 528 ? 149.859 126.531 173.615 1.00 45.17  ?  517 PRO A O   1 
ATOM   2778 C CB  . PRO A 1 528 ? 151.788 125.311 171.791 1.00 45.17  ?  517 PRO A CB  1 
ATOM   2779 C CG  . PRO A 1 528 ? 152.850 124.246 171.645 1.00 45.17  ?  517 PRO A CG  1 
ATOM   2780 C CD  . PRO A 1 528 ? 153.361 123.993 173.018 1.00 45.17  ?  517 PRO A CD  1 
ATOM   2781 N N   . GLY A 1 529 ? 151.095 125.618 175.252 1.00 39.90  ?  518 GLY A N   1 
ATOM   2782 C CA  . GLY A 1 529 ? 150.041 125.671 176.239 1.00 39.90  ?  518 GLY A CA  1 
ATOM   2783 C C   . GLY A 1 529 ? 150.534 126.343 177.496 1.00 39.90  ?  518 GLY A C   1 
ATOM   2784 O O   . GLY A 1 529 ? 150.022 126.092 178.589 1.00 39.90  ?  518 GLY A O   1 
ATOM   2785 N N   . SER A 1 530 ? 151.532 127.205 177.348 1.00 36.12  ?  519 SER A N   1 
ATOM   2786 C CA  . SER A 1 530 ? 152.090 127.928 178.475 1.00 36.12  ?  519 SER A CA  1 
ATOM   2787 C C   . SER A 1 530 ? 151.302 129.213 178.699 1.00 36.12  ?  519 SER A C   1 
ATOM   2788 O O   . SER A 1 530 ? 150.285 129.470 178.052 1.00 36.12  ?  519 SER A O   1 
ATOM   2789 C CB  . SER A 1 530 ? 153.576 128.190 178.259 1.00 36.12  ?  519 SER A CB  1 
ATOM   2790 O OG  . SER A 1 530 ? 153.795 129.068 177.181 1.00 36.12  ?  519 SER A OG  1 
ATOM   2791 N N   . LEU A 1 531 ? 151.756 130.016 179.654 1.00 30.04  ?  520 LEU A N   1 
ATOM   2792 C CA  . LEU A 1 531 ? 151.110 131.265 180.014 1.00 30.04  ?  520 LEU A CA  1 
ATOM   2793 C C   . LEU A 1 531 ? 151.611 132.409 179.143 1.00 30.04  ?  520 LEU A C   1 
ATOM   2794 O O   . LEU A 1 531 ? 150.832 133.288 178.765 1.00 30.04  ?  520 LEU A O   1 
ATOM   2795 C CB  . LEU A 1 531 ? 151.350 131.525 181.499 1.00 30.04  ?  520 LEU A CB  1 
ATOM   2796 C CG  . LEU A 1 531 ? 150.607 132.577 182.306 1.00 30.04  ?  520 LEU A CG  1 
ATOM   2797 C CD1 . LEU A 1 531 ? 149.140 132.315 182.284 1.00 30.04  ?  520 LEU A CD1 1 
ATOM   2798 C CD2 . LEU A 1 531 ? 151.065 132.463 183.703 1.00 30.04  ?  520 LEU A CD2 1 
ATOM   2799 N N   . LEU A 1 532 ? 152.893 132.368 178.779 1.00 26.91  ?  521 LEU A N   1 
ATOM   2800 C CA  . LEU A 1 532 ? 153.476 133.304 177.823 1.00 26.91  ?  521 LEU A CA  1 
ATOM   2801 C C   . LEU A 1 532 ? 152.829 133.197 176.452 1.00 26.91  ?  521 LEU A C   1 
ATOM   2802 O O   . LEU A 1 532 ? 152.679 134.205 175.756 1.00 26.91  ?  521 LEU A O   1 
ATOM   2803 C CB  . LEU A 1 532 ? 154.975 133.048 177.729 1.00 26.91  ?  521 LEU A CB  1 
ATOM   2804 C CG  . LEU A 1 532 ? 155.884 133.989 176.955 1.00 26.91  ?  521 LEU A CG  1 
ATOM   2805 C CD1 . LEU A 1 532 ? 155.517 135.433 177.191 1.00 26.91  ?  521 LEU A CD1 1 
ATOM   2806 C CD2 . LEU A 1 532 ? 157.329 133.747 177.309 1.00 26.91  ?  521 LEU A CD2 1 
ATOM   2807 N N   . SER A 1 533 ? 152.386 132.004 176.073 1.00 32.66  ?  522 SER A N   1 
ATOM   2808 C CA  . SER A 1 533 ? 151.724 131.841 174.788 1.00 32.66  ?  522 SER A CA  1 
ATOM   2809 C C   . SER A 1 533 ? 150.322 132.425 174.812 1.00 32.66  ?  522 SER A C   1 
ATOM   2810 O O   . SER A 1 533 ? 149.867 133.001 173.818 1.00 32.66  ?  522 SER A O   1 
ATOM   2811 C CB  . SER A 1 533 ? 151.686 130.364 174.415 1.00 32.66  ?  522 SER A CB  1 
ATOM   2812 O OG  . SER A 1 533 ? 152.999 129.852 174.293 1.00 32.66  ?  522 SER A OG  1 
ATOM   2813 N N   . LEU A 1 534 ? 149.628 132.302 175.944 1.00 26.94  ?  523 LEU A N   1 
ATOM   2814 C CA  . LEU A 1 534 ? 148.313 132.915 176.084 1.00 26.94  ?  523 LEU A CA  1 
ATOM   2815 C C   . LEU A 1 534 ? 148.409 134.433 176.093 1.00 26.94  ?  523 LEU A C   1 
ATOM   2816 O O   . LEU A 1 534 ? 147.585 135.107 175.465 1.00 26.94  ?  523 LEU A O   1 
ATOM   2817 C CB  . LEU A 1 534 ? 147.637 132.417 177.357 1.00 26.94  ?  523 LEU A CB  1 
ATOM   2818 C CG  . LEU A 1 534 ? 146.132 132.612 177.407 1.00 26.94  ?  523 LEU A CG  1 
ATOM   2819 C CD1 . LEU A 1 534 ? 145.509 131.918 176.248 1.00 26.94  ?  523 LEU A CD1 1 
ATOM   2820 C CD2 . LEU A 1 534 ? 145.603 132.034 178.672 1.00 26.94  ?  523 LEU A CD2 1 
ATOM   2821 N N   . PHE A 1 535 ? 149.414 134.978 176.788 1.00 19.84  ?  524 PHE A N   1 
ATOM   2822 C CA  . PHE A 1 535 ? 149.660 136.416 176.765 1.00 19.84  ?  524 PHE A CA  1 
ATOM   2823 C C   . PHE A 1 535 ? 149.947 136.907 175.357 1.00 19.84  ?  524 PHE A C   1 
ATOM   2824 O O   . PHE A 1 535 ? 149.432 137.952 174.948 1.00 19.84  ?  524 PHE A O   1 
ATOM   2825 C CB  . PHE A 1 535 ? 150.825 136.777 177.686 1.00 19.84  ?  524 PHE A CB  1 
ATOM   2826 C CG  . PHE A 1 535 ? 150.912 138.247 178.027 1.00 19.84  ?  524 PHE A CG  1 
ATOM   2827 C CD1 . PHE A 1 535 ? 151.557 139.140 177.190 1.00 19.84  ?  524 PHE A CD1 1 
ATOM   2828 C CD2 . PHE A 1 535 ? 150.363 138.729 179.203 1.00 19.84  ?  524 PHE A CD2 1 
ATOM   2829 C CE1 . PHE A 1 535 ? 151.634 140.467 177.510 1.00 19.84  ?  524 PHE A CE1 1 
ATOM   2830 C CE2 . PHE A 1 535 ? 150.457 140.054 179.520 1.00 19.84  ?  524 PHE A CE2 1 
ATOM   2831 C CZ  . PHE A 1 535 ? 151.093 140.920 178.672 1.00 19.84  ?  524 PHE A CZ  1 
ATOM   2832 N N   . ARG A 1 536 ? 150.743 136.155 174.594 1.00 22.73  ?  525 ARG A N   1 
ATOM   2833 C CA  . ARG A 1 536 ? 151.091 136.592 173.252 1.00 22.73  ?  525 ARG A CA  1 
ATOM   2834 C C   . ARG A 1 536 ? 149.919 136.482 172.291 1.00 22.73  ?  525 ARG A C   1 
ATOM   2835 O O   . ARG A 1 536 ? 149.809 137.292 171.375 1.00 22.73  ?  525 ARG A O   1 
ATOM   2836 C CB  . ARG A 1 536 ? 152.278 135.790 172.738 1.00 22.73  ?  525 ARG A CB  1 
ATOM   2837 C CG  . ARG A 1 536 ? 153.612 136.254 173.277 1.00 22.73  ?  525 ARG A CG  1 
ATOM   2838 C CD  . ARG A 1 536 ? 154.749 135.346 172.841 1.00 22.73  ?  525 ARG A CD  1 
ATOM   2839 N NE  . ARG A 1 536 ? 156.052 135.942 173.106 1.00 22.73  ?  525 ARG A NE  1 
ATOM   2840 C CZ  . ARG A 1 536 ? 157.101 135.261 173.539 1.00 22.73  ?  525 ARG A CZ  1 
ATOM   2841 N NH1 . ARG A 1 536 ? 156.990 133.966 173.754 1.00 22.73  1  525 ARG A NH1 1 
ATOM   2842 N NH2 . ARG A 1 536 ? 158.251 135.875 173.759 1.00 22.73  ?  525 ARG A NH2 1 
ATOM   2843 N N   . ARG A 1 537 ? 149.027 135.516 172.480 1.00 28.57  ?  526 ARG A N   1 
ATOM   2844 C CA  . ARG A 1 537 ? 147.880 135.435 171.583 1.00 28.57  ?  526 ARG A CA  1 
ATOM   2845 C C   . ARG A 1 537 ? 146.842 136.501 171.895 1.00 28.57  ?  526 ARG A C   1 
ATOM   2846 O O   . ARG A 1 537 ? 146.297 137.142 170.981 1.00 28.57  ?  526 ARG A O   1 
ATOM   2847 C CB  . ARG A 1 537 ? 147.242 134.051 171.663 1.00 28.57  ?  526 ARG A CB  1 
ATOM   2848 C CG  . ARG A 1 537 ? 147.964 132.958 170.894 1.00 28.57  ?  526 ARG A CG  1 
ATOM   2849 C CD  . ARG A 1 537 ? 147.300 131.608 171.107 1.00 28.57  ?  526 ARG A CD  1 
ATOM   2850 N NE  . ARG A 1 537 ? 146.088 131.463 170.310 1.00 28.57  ?  526 ARG A NE  1 
ATOM   2851 C CZ  . ARG A 1 537 ? 145.206 130.480 170.451 1.00 28.57  ?  526 ARG A CZ  1 
ATOM   2852 N NH1 . ARG A 1 537 ? 145.389 129.543 171.365 1.00 28.57  1  526 ARG A NH1 1 
ATOM   2853 N NH2 . ARG A 1 537 ? 144.136 130.439 169.674 1.00 28.57  ?  526 ARG A NH2 1 
ATOM   2854 N N   . LEU A 1 538 ? 146.565 136.700 173.188 1.00 21.39  ?  527 LEU A N   1 
ATOM   2855 C CA  . LEU A 1 538 ? 145.600 137.694 173.632 1.00 21.39  ?  527 LEU A CA  1 
ATOM   2856 C C   . LEU A 1 538 ? 146.051 139.108 173.297 1.00 21.39  ?  527 LEU A C   1 
ATOM   2857 O O   . LEU A 1 538 ? 145.248 139.919 172.832 1.00 21.39  ?  527 LEU A O   1 
ATOM   2858 C CB  . LEU A 1 538 ? 145.371 137.537 175.129 1.00 21.39  ?  527 LEU A CB  1 
ATOM   2859 C CG  . LEU A 1 538 ? 144.500 136.361 175.542 1.00 21.39  ?  527 LEU A CG  1 
ATOM   2860 C CD1 . LEU A 1 538 ? 144.478 136.239 177.023 1.00 21.39  ?  527 LEU A CD1 1 
ATOM   2861 C CD2 . LEU A 1 538 ? 143.109 136.507 175.007 1.00 21.39  ?  527 LEU A CD2 1 
ATOM   2862 N N   . SER A 1 539 ? 147.331 139.418 173.487 1.00 22.12  ?  528 SER A N   1 
ATOM   2863 C CA  . SER A 1 539 ? 147.780 140.757 173.165 1.00 22.12  ?  528 SER A CA  1 
ATOM   2864 C C   . SER A 1 539 ? 147.921 140.998 171.671 1.00 22.12  ?  528 SER A C   1 
ATOM   2865 O O   . SER A 1 539 ? 148.058 142.153 171.264 1.00 22.12  ?  528 SER A O   1 
ATOM   2866 C CB  . SER A 1 539 ? 149.094 141.044 173.873 1.00 22.12  ?  528 SER A CB  1 
ATOM   2867 O OG  . SER A 1 539 ? 150.182 140.616 173.102 1.00 22.12  ?  528 SER A OG  1 
ATOM   2868 N N   . ASP A 1 540 ? 147.899 139.952 170.847 1.00 29.62  ?  529 ASP A N   1 
ATOM   2869 C CA  . ASP A 1 540 ? 147.757 140.164 169.414 1.00 29.62  ?  529 ASP A CA  1 
ATOM   2870 C C   . ASP A 1 540 ? 146.316 140.459 169.050 1.00 29.62  ?  529 ASP A C   1 
ATOM   2871 O O   . ASP A 1 540 ? 146.058 141.322 168.211 1.00 29.62  ?  529 ASP A O   1 
ATOM   2872 C CB  . ASP A 1 540 ? 148.236 138.952 168.619 1.00 29.62  ?  529 ASP A CB  1 
ATOM   2873 C CG  . ASP A 1 540 ? 149.739 138.736 168.707 1.00 29.62  ?  529 ASP A CG  1 
ATOM   2874 O OD1 . ASP A 1 540 ? 150.478 139.694 168.973 1.00 29.62  ?  529 ASP A OD1 1 
ATOM   2875 O OD2 . ASP A 1 540 ? 150.189 137.584 168.499 1.00 29.62  -1 529 ASP A OD2 1 
ATOM   2876 N N   . GLN A 1 541 ? 145.364 139.745 169.653 1.00 23.81  ?  530 GLN A N   1 
ATOM   2877 C CA  . GLN A 1 541 ? 143.961 140.018 169.352 1.00 23.81  ?  530 GLN A CA  1 
ATOM   2878 C C   . GLN A 1 541 ? 143.477 141.348 169.906 1.00 23.81  ?  530 GLN A C   1 
ATOM   2879 O O   . GLN A 1 541 ? 142.492 141.883 169.395 1.00 23.81  ?  530 GLN A O   1 
ATOM   2880 C CB  . GLN A 1 541 ? 143.050 138.927 169.899 1.00 23.81  ?  530 GLN A CB  1 
ATOM   2881 C CG  . GLN A 1 541 ? 143.295 137.557 169.358 1.00 23.81  ?  530 GLN A CG  1 
ATOM   2882 C CD  . GLN A 1 541 ? 142.839 137.391 167.936 1.00 23.81  ?  530 GLN A CD  1 
ATOM   2883 O OE1 . GLN A 1 541 ? 141.664 137.548 167.619 1.00 23.81  ?  530 GLN A OE1 1 
ATOM   2884 N NE2 . GLN A 1 541 ? 143.776 137.059 167.063 1.00 23.81  ?  530 GLN A NE2 1 
ATOM   2885 N N   . ARG A 1 542 ? 144.105 141.877 170.960 1.00 15.81  ?  531 ARG A N   1 
ATOM   2886 C CA  . ARG A 1 542 ? 143.620 143.119 171.557 1.00 15.81  ?  531 ARG A CA  1 
ATOM   2887 C C   . ARG A 1 542 ? 144.012 144.327 170.716 1.00 15.81  ?  531 ARG A C   1 
ATOM   2888 O O   . ARG A 1 542 ? 143.258 145.298 170.626 1.00 15.81  ?  531 ARG A O   1 
ATOM   2889 C CB  . ARG A 1 542 ? 144.130 143.238 173.000 1.00 15.81  ?  531 ARG A CB  1 
ATOM   2890 C CG  . ARG A 1 542 ? 144.122 144.624 173.666 1.00 15.81  ?  531 ARG A CG  1 
ATOM   2891 C CD  . ARG A 1 542 ? 142.730 145.165 173.904 1.00 15.81  ?  531 ARG A CD  1 
ATOM   2892 N NE  . ARG A 1 542 ? 142.736 146.424 174.638 1.00 15.81  ?  531 ARG A NE  1 
ATOM   2893 C CZ  . ARG A 1 542 ? 142.752 147.632 174.091 1.00 15.81  ?  531 ARG A CZ  1 
ATOM   2894 N NH1 . ARG A 1 542 ? 142.767 147.774 172.790 1.00 15.81  1  531 ARG A NH1 1 
ATOM   2895 N NH2 . ARG A 1 542 ? 142.754 148.703 174.857 1.00 15.81  ?  531 ARG A NH2 1 
ATOM   2896 N N   . SER A 1 543 ? 145.159 144.280 170.066 1.00 22.19  ?  532 SER A N   1 
ATOM   2897 C CA  . SER A 1 543 ? 145.647 145.433 169.337 1.00 22.19  ?  532 SER A CA  1 
ATOM   2898 C C   . SER A 1 543 ? 145.221 145.462 167.870 1.00 22.19  ?  532 SER A C   1 
ATOM   2899 O O   . SER A 1 543 ? 145.688 146.330 167.132 1.00 22.19  ?  532 SER A O   1 
ATOM   2900 C CB  . SER A 1 543 ? 147.168 145.508 169.452 1.00 22.19  ?  532 SER A CB  1 
ATOM   2901 O OG  . SER A 1 543 ? 147.773 144.403 168.827 1.00 22.19  ?  532 SER A OG  1 
ATOM   2902 N N   . LYS A 1 544 ? 144.326 144.581 167.428 1.00 25.07  ?  533 LYS A N   1 
ATOM   2903 C CA  . LYS A 1 544 ? 143.924 144.665 166.030 1.00 25.07  ?  533 LYS A CA  1 
ATOM   2904 C C   . LYS A 1 544 ? 142.422 144.571 165.777 1.00 25.07  ?  533 LYS A C   1 
ATOM   2905 O O   . LYS A 1 544 ? 141.950 145.027 164.736 1.00 25.07  ?  533 LYS A O   1 
ATOM   2906 C CB  . LYS A 1 544 ? 144.649 143.594 165.215 1.00 25.07  ?  533 LYS A CB  1 
ATOM   2907 C CG  . LYS A 1 544 ? 144.237 142.191 165.535 1.00 25.07  ?  533 LYS A CG  1 
ATOM   2908 C CD  . LYS A 1 544 ? 145.048 141.184 164.778 1.00 25.07  ?  533 LYS A CD  1 
ATOM   2909 C CE  . LYS A 1 544 ? 144.569 139.791 165.110 1.00 25.07  ?  533 LYS A CE  1 
ATOM   2910 N NZ  . LYS A 1 544 ? 143.085 139.763 165.208 1.00 25.07  1  533 LYS A NZ  1 
ATOM   2911 N N   . GLU A 1 545 ? 141.654 143.995 166.692 1.00 27.32  ?  534 GLU A N   1 
ATOM   2912 C CA  . GLU A 1 545 ? 140.223 143.846 166.466 1.00 27.32  ?  534 GLU A CA  1 
ATOM   2913 C C   . GLU A 1 545 ? 139.484 145.091 166.919 1.00 27.32  ?  534 GLU A C   1 
ATOM   2914 O O   . GLU A 1 545 ? 139.645 145.529 168.055 1.00 27.32  ?  534 GLU A O   1 
ATOM   2915 C CB  . GLU A 1 545 ? 139.687 142.631 167.212 1.00 27.32  ?  534 GLU A CB  1 
ATOM   2916 C CG  . GLU A 1 545 ? 140.292 141.339 166.765 1.00 27.32  ?  534 GLU A CG  1 
ATOM   2917 C CD  . GLU A 1 545 ? 139.962 140.982 165.327 1.00 27.32  ?  534 GLU A CD  1 
ATOM   2918 O OE1 . GLU A 1 545 ? 138.864 141.320 164.844 1.00 27.32  ?  534 GLU A OE1 1 
ATOM   2919 O OE2 . GLU A 1 545 ? 140.814 140.353 164.668 1.00 27.32  -1 534 GLU A OE2 1 
ATOM   2920 N N   . ARG A 1 546 ? 138.660 145.651 166.042 1.00 26.82  ?  535 ARG A N   1 
ATOM   2921 C CA  . ARG A 1 546 ? 138.016 146.924 166.331 1.00 26.82  ?  535 ARG A CA  1 
ATOM   2922 C C   . ARG A 1 546 ? 136.945 146.833 167.395 1.00 26.82  ?  535 ARG A C   1 
ATOM   2923 O O   . ARG A 1 546 ? 136.679 147.832 168.060 1.00 26.82  ?  535 ARG A O   1 
ATOM   2924 C CB  . ARG A 1 546 ? 137.389 147.514 165.077 1.00 26.82  ?  535 ARG A CB  1 
ATOM   2925 C CG  . ARG A 1 546 ? 138.304 148.400 164.289 1.00 26.82  ?  535 ARG A CG  1 
ATOM   2926 C CD  . ARG A 1 546 ? 137.505 149.038 163.211 1.00 26.82  ?  535 ARG A CD  1 
ATOM   2927 N NE  . ARG A 1 546 ? 138.308 149.784 162.256 1.00 26.82  ?  535 ARG A NE  1 
ATOM   2928 C CZ  . ARG A 1 546 ? 137.842 150.168 161.075 1.00 26.82  ?  535 ARG A CZ  1 
ATOM   2929 N NH1 . ARG A 1 546 ? 138.610 150.846 160.235 1.00 26.82  1  535 ARG A NH1 1 
ATOM   2930 N NH2 . ARG A 1 546 ? 136.598 149.858 160.741 1.00 26.82  ?  535 ARG A NH2 1 
ATOM   2931 N N   . SER A 1 547 ? 136.316 145.686 167.576 1.00 19.75  ?  536 SER A N   1 
ATOM   2932 C CA  . SER A 1 547 ? 135.370 145.559 168.666 1.00 19.75  ?  536 SER A CA  1 
ATOM   2933 C C   . SER A 1 547 ? 136.042 145.280 170.001 1.00 19.75  ?  536 SER A C   1 
ATOM   2934 O O   . SER A 1 547 ? 135.386 145.386 171.030 1.00 19.75  ?  536 SER A O   1 
ATOM   2935 C CB  . SER A 1 547 ? 134.347 144.479 168.347 1.00 19.75  ?  536 SER A CB  1 
ATOM   2936 O OG  . SER A 1 547 ? 134.955 143.221 168.245 1.00 19.75  ?  536 SER A OG  1 
ATOM   2937 N N   . LEU A 1 548 ? 137.327 144.943 170.007 1.00 16.69  ?  537 LEU A N   1 
ATOM   2938 C CA  . LEU A 1 548 ? 138.131 144.896 171.215 1.00 16.69  ?  537 LEU A CA  1 
ATOM   2939 C C   . LEU A 1 548 ? 138.992 146.128 171.394 1.00 16.69  ?  537 LEU A C   1 
ATOM   2940 O O   . LEU A 1 548 ? 139.671 146.244 172.407 1.00 16.69  ?  537 LEU A O   1 
ATOM   2941 C CB  . LEU A 1 548 ? 139.035 143.669 171.223 1.00 16.69  ?  537 LEU A CB  1 
ATOM   2942 C CG  . LEU A 1 548 ? 138.432 142.301 171.524 1.00 16.69  ?  537 LEU A CG  1 
ATOM   2943 C CD1 . LEU A 1 548 ? 139.537 141.310 171.716 1.00 16.69  ?  537 LEU A CD1 1 
ATOM   2944 C CD2 . LEU A 1 548 ? 137.520 142.330 172.718 1.00 16.69  ?  537 LEU A CD2 1 
ATOM   2945 N N   . LEU A 1 549 ? 138.999 147.036 170.431 1.00 16.84  ?  538 LEU A N   1 
ATOM   2946 C CA  . LEU A 1 549 ? 139.745 148.277 170.517 1.00 16.84  ?  538 LEU A CA  1 
ATOM   2947 C C   . LEU A 1 549 ? 138.864 149.424 170.973 1.00 16.84  ?  538 LEU A C   1 
ATOM   2948 O O   . LEU A 1 549 ? 139.290 150.248 171.776 1.00 16.84  ?  538 LEU A O   1 
ATOM   2949 C CB  . LEU A 1 549 ? 140.375 148.600 169.165 1.00 16.84  ?  538 LEU A CB  1 
ATOM   2950 C CG  . LEU A 1 549 ? 141.738 147.999 168.867 1.00 16.84  ?  538 LEU A CG  1 
ATOM   2951 C CD1 . LEU A 1 549 ? 141.957 147.928 167.407 1.00 16.84  ?  538 LEU A CD1 1 
ATOM   2952 C CD2 . LEU A 1 549 ? 142.779 148.860 169.473 1.00 16.84  ?  538 LEU A CD2 1 
ATOM   2953 N N   . HIS A 1 550 ? 137.653 149.524 170.437 1.00 18.45  ?  539 HIS A N   1 
ATOM   2954 C CA  . HIS A 1 550 ? 136.704 150.521 170.899 1.00 18.45  ?  539 HIS A CA  1 
ATOM   2955 C C   . HIS A 1 550 ? 135.278 150.021 170.826 1.00 18.45  ?  539 HIS A C   1 
ATOM   2956 O O   . HIS A 1 550 ? 134.357 150.815 170.655 1.00 18.45  ?  539 HIS A O   1 
ATOM   2957 C CB  . HIS A 1 550 ? 136.817 151.828 170.120 1.00 18.45  ?  539 HIS A CB  1 
ATOM   2958 C CG  . HIS A 1 550 ? 137.125 151.651 168.670 1.00 18.45  ?  539 HIS A CG  1 
ATOM   2959 N ND1 . HIS A 1 550 ? 136.213 151.155 167.769 1.00 18.45  ?  539 HIS A ND1 1 
ATOM   2960 C CD2 . HIS A 1 550 ? 138.248 151.912 167.964 1.00 18.45  ?  539 HIS A CD2 1 
ATOM   2961 C CE1 . HIS A 1 550 ? 136.764 151.109 166.573 1.00 18.45  ?  539 HIS A CE1 1 
ATOM   2962 N NE2 . HIS A 1 550 ? 137.998 151.563 166.665 1.00 18.45  ?  539 HIS A NE2 1 
ATOM   2963 N N   . GLY A 1 551 ? 135.064 148.750 170.976 1.00 17.62  ?  540 GLY A N   1 
ATOM   2964 C CA  . GLY A 1 551 ? 133.717 148.232 170.951 1.00 17.62  ?  540 GLY A CA  1 
ATOM   2965 C C   . GLY A 1 551 ? 132.925 148.542 172.200 1.00 17.62  ?  540 GLY A C   1 
ATOM   2966 O O   . GLY A 1 551 ? 133.400 149.127 173.162 1.00 17.62  ?  540 GLY A O   1 
ATOM   2967 N N   . ASP A 1 552 ? 131.671 148.133 172.184 1.00 24.65  ?  541 ASP A N   1 
ATOM   2968 C CA  . ASP A 1 552 ? 130.785 148.375 173.303 1.00 24.65  ?  541 ASP A CA  1 
ATOM   2969 C C   . ASP A 1 552 ? 130.689 147.135 174.164 1.00 24.65  ?  541 ASP A C   1 
ATOM   2970 O O   . ASP A 1 552 ? 130.572 146.023 173.664 1.00 24.65  ?  541 ASP A O   1 
ATOM   2971 C CB  . ASP A 1 552 ? 129.389 148.767 172.834 1.00 24.65  ?  541 ASP A CB  1 
ATOM   2972 C CG  . ASP A 1 552 ? 129.354 150.107 172.163 1.00 24.65  ?  541 ASP A CG  1 
ATOM   2973 O OD1 . ASP A 1 552 ? 130.328 150.874 172.286 1.00 24.65  ?  541 ASP A OD1 1 
ATOM   2974 O OD2 . ASP A 1 552 ? 128.334 150.400 171.510 1.00 24.65  -1 541 ASP A OD2 1 
ATOM   2975 N N   . PHE A 1 553 ? 130.692 147.344 175.469 1.00 19.53  ?  542 PHE A N   1 
ATOM   2976 C CA  . PHE A 1 553 ? 130.674 146.278 176.452 1.00 19.53  ?  542 PHE A CA  1 
ATOM   2977 C C   . PHE A 1 553 ? 129.241 146.064 176.899 1.00 19.53  ?  542 PHE A C   1 
ATOM   2978 O O   . PHE A 1 553 ? 128.535 147.029 177.184 1.00 19.53  ?  542 PHE A O   1 
ATOM   2979 C CB  . PHE A 1 553 ? 131.583 146.653 177.628 1.00 19.53  ?  542 PHE A CB  1 
ATOM   2980 C CG  . PHE A 1 553 ? 131.392 145.824 178.869 1.00 19.53  ?  542 PHE A CG  1 
ATOM   2981 C CD1 . PHE A 1 553 ? 132.013 144.611 179.010 1.00 19.53  ?  542 PHE A CD1 1 
ATOM   2982 C CD2 . PHE A 1 553 ? 130.625 146.296 179.914 1.00 19.53  ?  542 PHE A CD2 1 
ATOM   2983 C CE1 . PHE A 1 553 ? 131.847 143.885 180.138 1.00 19.53  ?  542 PHE A CE1 1 
ATOM   2984 C CE2 . PHE A 1 553 ? 130.456 145.564 181.026 1.00 19.53  ?  542 PHE A CE2 1 
ATOM   2985 C CZ  . PHE A 1 553 ? 131.073 144.357 181.138 1.00 19.53  ?  542 PHE A CZ  1 
ATOM   2986 N N   . HIS A 1 554 ? 128.815 144.810 176.968 1.00 23.04  ?  543 HIS A N   1 
ATOM   2987 C CA  . HIS A 1 554 ? 127.506 144.489 177.516 1.00 23.04  ?  543 HIS A CA  1 
ATOM   2988 C C   . HIS A 1 554 ? 127.600 143.151 178.218 1.00 23.04  ?  543 HIS A C   1 
ATOM   2989 O O   . HIS A 1 554 ? 128.066 142.182 177.626 1.00 23.04  ?  543 HIS A O   1 
ATOM   2990 C CB  . HIS A 1 554 ? 126.440 144.455 176.422 1.00 23.04  ?  543 HIS A CB  1 
ATOM   2991 C CG  . HIS A 1 554 ? 125.885 145.804 176.094 1.00 23.04  ?  543 HIS A CG  1 
ATOM   2992 N ND1 . HIS A 1 554 ? 126.321 146.549 175.021 1.00 23.04  ?  543 HIS A ND1 1 
ATOM   2993 C CD2 . HIS A 1 554 ? 124.964 146.564 176.728 1.00 23.04  ?  543 HIS A CD2 1 
ATOM   2994 C CE1 . HIS A 1 554 ? 125.688 147.706 175.005 1.00 23.04  ?  543 HIS A CE1 1 
ATOM   2995 N NE2 . HIS A 1 554 ? 124.856 147.739 176.028 1.00 23.04  ?  543 HIS A NE2 1 
ATOM   2996 N N   . ALA A 1 555 ? 127.180 143.098 179.469 1.00 26.37  ?  544 ALA A N   1 
ATOM   2997 C CA  . ALA A 1 555 ? 127.186 141.862 180.233 1.00 26.37  ?  544 ALA A CA  1 
ATOM   2998 C C   . ALA A 1 555 ? 125.767 141.348 180.391 1.00 26.37  ?  544 ALA A C   1 
ATOM   2999 O O   . ALA A 1 555 ? 124.816 142.126 180.448 1.00 26.37  ?  544 ALA A O   1 
ATOM   3000 C CB  . ALA A 1 555 ? 127.814 142.070 181.604 1.00 26.37  ?  544 ALA A CB  1 
ATOM   3001 N N   . PHE A 1 556 ? 125.617 140.034 180.441 1.00 37.90  ?  545 PHE A N   1 
ATOM   3002 C CA  . PHE A 1 556 ? 124.302 139.459 180.642 1.00 37.90  ?  545 PHE A CA  1 
ATOM   3003 C C   . PHE A 1 556 ? 124.378 138.358 181.682 1.00 37.90  ?  545 PHE A C   1 
ATOM   3004 O O   . PHE A 1 556 ? 125.454 137.885 182.043 1.00 37.90  ?  545 PHE A O   1 
ATOM   3005 C CB  . PHE A 1 556 ? 123.701 138.926 179.342 1.00 37.90  ?  545 PHE A CB  1 
ATOM   3006 C CG  . PHE A 1 556 ? 124.672 138.186 178.475 1.00 37.90  ?  545 PHE A CG  1 
ATOM   3007 C CD1 . PHE A 1 556 ? 124.886 136.842 178.658 1.00 37.90  ?  545 PHE A CD1 1 
ATOM   3008 C CD2 . PHE A 1 556 ? 125.334 138.830 177.446 1.00 37.90  ?  545 PHE A CD2 1 
ATOM   3009 C CE1 . PHE A 1 556 ? 125.752 136.175 177.858 1.00 37.90  ?  545 PHE A CE1 1 
ATOM   3010 C CE2 . PHE A 1 556 ? 126.205 138.156 176.657 1.00 37.90  ?  545 PHE A CE2 1 
ATOM   3011 C CZ  . PHE A 1 556 ? 126.417 136.837 176.863 1.00 37.90  ?  545 PHE A CZ  1 
ATOM   3012 N N   . SER A 1 557 ? 123.207 137.953 182.160 1.00 52.91  ?  546 SER A N   1 
ATOM   3013 C CA  . SER A 1 557 ? 123.119 137.003 183.255 1.00 52.91  ?  546 SER A CA  1 
ATOM   3014 C C   . SER A 1 557 ? 123.311 135.580 182.760 1.00 52.91  ?  546 SER A C   1 
ATOM   3015 O O   . SER A 1 557 ? 122.920 135.221 181.648 1.00 52.91  ?  546 SER A O   1 
ATOM   3016 C CB  . SER A 1 557 ? 121.779 137.132 183.968 1.00 52.91  ?  546 SER A CB  1 
ATOM   3017 O OG  . SER A 1 557 ? 121.674 138.389 184.604 1.00 52.91  ?  546 SER A OG  1 
ATOM   3018 N N   . ALA A 1 558 ? 123.910 134.766 183.616 1.00 61.58  ?  547 ALA A N   1 
ATOM   3019 C CA  . ALA A 1 558 ? 124.249 133.398 183.277 1.00 61.58  ?  547 ALA A CA  1 
ATOM   3020 C C   . ALA A 1 558 ? 124.070 132.559 184.538 1.00 61.58  ?  547 ALA A C   1 
ATOM   3021 O O   . ALA A 1 558 ? 123.358 132.960 185.463 1.00 61.58  ?  547 ALA A O   1 
ATOM   3022 C CB  . ALA A 1 558 ? 125.667 133.329 182.685 1.00 61.58  ?  547 ALA A CB  1 
ATOM   3023 N N   . GLY A 1 559 ? 124.709 131.388 184.573 1.00 61.09  ?  548 GLY A N   1 
ATOM   3024 C CA  . GLY A 1 559 ? 124.556 130.476 185.669 1.00 61.09  ?  548 GLY A CA  1 
ATOM   3025 C C   . GLY A 1 559 ? 125.222 130.966 186.946 1.00 61.09  ?  548 GLY A C   1 
ATOM   3026 O O   . GLY A 1 559 ? 125.822 132.046 186.995 1.00 61.09  ?  548 GLY A O   1 
ATOM   3027 N N   . PRO A 1 560 ? 125.116 130.163 188.000 1.00 62.44  ?  549 PRO A N   1 
ATOM   3028 C CA  . PRO A 1 560 ? 125.665 130.548 189.314 1.00 62.44  ?  549 PRO A CA  1 
ATOM   3029 C C   . PRO A 1 560 ? 127.182 130.396 189.402 1.00 62.44  ?  549 PRO A C   1 
ATOM   3030 O O   . PRO A 1 560 ? 127.741 129.333 189.655 1.00 62.44  ?  549 PRO A O   1 
ATOM   3031 C CB  . PRO A 1 560 ? 124.927 129.610 190.272 1.00 62.44  ?  549 PRO A CB  1 
ATOM   3032 C CG  . PRO A 1 560 ? 124.624 128.415 189.475 1.00 62.44  ?  549 PRO A CG  1 
ATOM   3033 C CD  . PRO A 1 560 ? 124.453 128.850 188.047 1.00 62.44  ?  549 PRO A CD  1 
ATOM   3034 N N   . GLY A 1 561 ? 127.888 131.490 189.137 1.00 55.12  ?  550 GLY A N   1 
ATOM   3035 C CA  . GLY A 1 561 ? 129.326 131.495 189.317 1.00 55.12  ?  550 GLY A CA  1 
ATOM   3036 C C   . GLY A 1 561 ? 130.074 131.834 188.051 1.00 55.12  ?  550 GLY A C   1 
ATOM   3037 O O   . GLY A 1 561 ? 131.288 131.647 187.963 1.00 55.12  ?  550 GLY A O   1 
ATOM   3038 N N   . LEU A 1 562 ? 129.343 132.340 187.064 1.00 47.25  ?  551 LEU A N   1 
ATOM   3039 C CA  . LEU A 1 562 ? 129.892 132.695 185.772 1.00 47.25  ?  551 LEU A CA  1 
ATOM   3040 C C   . LEU A 1 562 ? 129.984 134.207 185.622 1.00 47.25  ?  551 LEU A C   1 
ATOM   3041 O O   . LEU A 1 562 ? 129.445 134.977 186.415 1.00 47.25  ?  551 LEU A O   1 
ATOM   3042 C CB  . LEU A 1 562 ? 129.037 132.104 184.662 1.00 47.25  ?  551 LEU A CB  1 
ATOM   3043 C CG  . LEU A 1 562 ? 129.110 130.594 184.534 1.00 47.25  ?  551 LEU A CG  1 
ATOM   3044 C CD1 . LEU A 1 562 ? 127.842 130.062 183.931 1.00 47.25  ?  551 LEU A CD1 1 
ATOM   3045 C CD2 . LEU A 1 562 ? 130.272 130.239 183.666 1.00 47.25  ?  551 LEU A CD2 1 
ATOM   3046 N N   . PHE A 1 563 ? 130.677 134.633 184.574 1.00 29.79  ?  552 PHE A N   1 
ATOM   3047 C CA  . PHE A 1 563 ? 130.759 136.036 184.183 1.00 29.79  ?  552 PHE A CA  1 
ATOM   3048 C C   . PHE A 1 563 ? 130.888 136.013 182.669 1.00 29.79  ?  552 PHE A C   1 
ATOM   3049 O O   . PHE A 1 563 ? 131.897 135.559 182.139 1.00 29.79  ?  552 PHE A O   1 
ATOM   3050 C CB  . PHE A 1 563 ? 131.939 136.732 184.871 1.00 29.79  ?  552 PHE A CB  1 
ATOM   3051 C CG  . PHE A 1 563 ? 132.117 138.204 184.537 1.00 29.79  ?  552 PHE A CG  1 
ATOM   3052 C CD1 . PHE A 1 563 ? 131.091 138.988 184.025 1.00 29.79  ?  552 PHE A CD1 1 
ATOM   3053 C CD2 . PHE A 1 563 ? 133.336 138.808 184.774 1.00 29.79  ?  552 PHE A CD2 1 
ATOM   3054 C CE1 . PHE A 1 563 ? 131.298 140.316 183.724 1.00 29.79  ?  552 PHE A CE1 1 
ATOM   3055 C CE2 . PHE A 1 563 ? 133.537 140.137 184.483 1.00 29.79  ?  552 PHE A CE2 1 
ATOM   3056 C CZ  . PHE A 1 563 ? 132.516 140.886 183.959 1.00 29.79  ?  552 PHE A CZ  1 
ATOM   3057 N N   . SER A 1 564 ? 129.863 136.500 181.985 1.00 28.33  ?  553 SER A N   1 
ATOM   3058 C CA  . SER A 1 564 ? 129.809 136.470 180.536 1.00 28.33  ?  553 SER A CA  1 
ATOM   3059 C C   . SER A 1 564 ? 129.517 137.861 179.999 1.00 28.33  ?  553 SER A C   1 
ATOM   3060 O O   . SER A 1 564 ? 128.713 138.592 180.572 1.00 28.33  ?  553 SER A O   1 
ATOM   3061 C CB  . SER A 1 564 ? 128.743 135.489 180.062 1.00 28.33  ?  553 SER A CB  1 
ATOM   3062 O OG  . SER A 1 564 ? 128.705 135.439 178.657 1.00 28.33  ?  553 SER A OG  1 
ATOM   3063 N N   . TYR A 1 565 ? 130.173 138.224 178.901 1.00 18.13  ?  554 TYR A N   1 
ATOM   3064 C CA  . TYR A 1 565 ? 129.945 139.523 178.290 1.00 18.13  ?  554 TYR A CA  1 
ATOM   3065 C C   . TYR A 1 565 ? 130.339 139.486 176.825 1.00 18.13  ?  554 TYR A C   1 
ATOM   3066 O O   . TYR A 1 565 ? 130.961 138.536 176.354 1.00 18.13  ?  554 TYR A O   1 
ATOM   3067 C CB  . TYR A 1 565 ? 130.703 140.640 179.008 1.00 18.13  ?  554 TYR A CB  1 
ATOM   3068 C CG  . TYR A 1 565 ? 132.195 140.470 179.124 1.00 18.13  ?  554 TYR A CG  1 
ATOM   3069 C CD1 . TYR A 1 565 ? 132.753 139.778 180.182 1.00 18.13  ?  554 TYR A CD1 1 
ATOM   3070 C CD2 . TYR A 1 565 ? 133.040 141.053 178.207 1.00 18.13  ?  554 TYR A CD2 1 
ATOM   3071 C CE1 . TYR A 1 565 ? 134.093 139.642 180.296 1.00 18.13  ?  554 TYR A CE1 1 
ATOM   3072 C CE2 . TYR A 1 565 ? 134.370 140.922 178.309 1.00 18.13  ?  554 TYR A CE2 1 
ATOM   3073 C CZ  . TYR A 1 565 ? 134.902 140.220 179.356 1.00 18.13  ?  554 TYR A CZ  1 
ATOM   3074 O OH  . TYR A 1 565 ? 136.256 140.098 179.451 1.00 18.13  ?  554 TYR A OH  1 
ATOM   3075 N N   . ILE A 1 566 ? 129.970 140.546 176.113 1.00 19.46  ?  555 ILE A N   1 
ATOM   3076 C CA  . ILE A 1 566 ? 130.159 140.657 174.673 1.00 19.46  ?  555 ILE A CA  1 
ATOM   3077 C C   . ILE A 1 566 ? 130.738 142.028 174.344 1.00 19.46  ?  555 ILE A C   1 
ATOM   3078 O O   . ILE A 1 566 ? 130.437 143.020 175.007 1.00 19.46  ?  555 ILE A O   1 
ATOM   3079 C CB  . ILE A 1 566 ? 128.818 140.392 173.934 1.00 19.46  ?  555 ILE A CB  1 
ATOM   3080 C CG1 . ILE A 1 566 ? 128.979 140.427 172.420 1.00 19.46  ?  555 ILE A CG1 1 
ATOM   3081 C CG2 . ILE A 1 566 ? 127.717 141.330 174.396 1.00 19.46  ?  555 ILE A CG2 1 
ATOM   3082 C CD1 . ILE A 1 566 ? 127.727 140.231 171.697 1.00 19.46  ?  555 ILE A CD1 1 
ATOM   3083 N N   . ARG A 1 567 ? 131.634 142.071 173.360 1.00 14.83  ?  556 ARG A N   1 
ATOM   3084 C CA  . ARG A 1 567 ? 132.207 143.310 172.850 1.00 14.83  ?  556 ARG A CA  1 
ATOM   3085 C C   . ARG A 1 567 ? 131.942 143.429 171.359 1.00 14.83  ?  556 ARG A C   1 
ATOM   3086 O O   . ARG A 1 567 ? 132.359 142.569 170.587 1.00 14.83  ?  556 ARG A O   1 
ATOM   3087 C CB  . ARG A 1 567 ? 133.707 143.369 173.098 1.00 14.83  ?  556 ARG A CB  1 
ATOM   3088 C CG  . ARG A 1 567 ? 134.140 143.131 174.523 1.00 14.83  ?  556 ARG A CG  1 
ATOM   3089 C CD  . ARG A 1 567 ? 134.107 144.380 175.407 1.00 14.83  ?  556 ARG A CD  1 
ATOM   3090 N NE  . ARG A 1 567 ? 134.512 145.602 174.739 1.00 14.83  ?  556 ARG A NE  1 
ATOM   3091 C CZ  . ARG A 1 567 ? 135.762 145.981 174.564 1.00 14.83  ?  556 ARG A CZ  1 
ATOM   3092 N NH1 . ARG A 1 567 ? 136.747 145.233 175.006 1.00 14.83  1  556 ARG A NH1 1 
ATOM   3093 N NH2 . ARG A 1 567 ? 136.022 147.107 173.935 1.00 14.83  ?  556 ARG A NH2 1 
ATOM   3094 N N   . HIS A 1 568 ? 131.288 144.515 170.949 1.00 22.80  ?  557 HIS A N   1 
ATOM   3095 C CA  . HIS A 1 568 ? 130.830 144.673 169.572 1.00 22.80  ?  557 HIS A CA  1 
ATOM   3096 C C   . HIS A 1 568 ? 130.973 146.123 169.140 1.00 22.80  ?  557 HIS A C   1 
ATOM   3097 O O   . HIS A 1 568 ? 130.589 147.021 169.883 1.00 22.80  ?  557 HIS A O   1 
ATOM   3098 C CB  . HIS A 1 568 ? 129.376 144.231 169.442 1.00 22.80  ?  557 HIS A CB  1 
ATOM   3099 C CG  . HIS A 1 568 ? 128.441 144.926 170.372 1.00 22.80  ?  557 HIS A CG  1 
ATOM   3100 N ND1 . HIS A 1 568 ? 127.625 145.953 169.964 1.00 22.80  ?  557 HIS A ND1 1 
ATOM   3101 C CD2 . HIS A 1 568 ? 128.187 144.741 171.687 1.00 22.80  ?  557 HIS A CD2 1 
ATOM   3102 C CE1 . HIS A 1 568 ? 126.909 146.375 170.989 1.00 22.80  ?  557 HIS A CE1 1 
ATOM   3103 N NE2 . HIS A 1 568 ? 127.232 145.657 172.047 1.00 22.80  ?  557 HIS A NE2 1 
ATOM   3104 N N   . TRP A 1 569 ? 131.523 146.367 167.952 1.00 24.75  ?  558 TRP A N   1 
ATOM   3105 C CA  . TRP A 1 569 ? 131.592 147.765 167.551 1.00 24.75  ?  558 TRP A CA  1 
ATOM   3106 C C   . TRP A 1 569 ? 130.486 148.194 166.586 1.00 24.75  ?  558 TRP A C   1 
ATOM   3107 O O   . TRP A 1 569 ? 129.548 148.885 166.999 1.00 24.75  ?  558 TRP A O   1 
ATOM   3108 C CB  . TRP A 1 569 ? 132.976 148.061 166.959 1.00 24.75  ?  558 TRP A CB  1 
ATOM   3109 C CG  . TRP A 1 569 ? 133.073 149.327 166.175 1.00 24.75  ?  558 TRP A CG  1 
ATOM   3110 C CD1 . TRP A 1 569 ? 133.355 149.428 164.860 1.00 24.75  ?  558 TRP A CD1 1 
ATOM   3111 C CD2 . TRP A 1 569 ? 132.864 150.666 166.643 1.00 24.75  ?  558 TRP A CD2 1 
ATOM   3112 N NE1 . TRP A 1 569 ? 133.337 150.737 164.464 1.00 24.75  ?  558 TRP A NE1 1 
ATOM   3113 C CE2 . TRP A 1 569 ? 133.035 151.520 165.542 1.00 24.75  ?  558 TRP A CE2 1 
ATOM   3114 C CE3 . TRP A 1 569 ? 132.555 151.226 167.884 1.00 24.75  ?  558 TRP A CE3 1 
ATOM   3115 C CZ2 . TRP A 1 569 ? 132.914 152.895 165.642 1.00 24.75  ?  558 TRP A CZ2 1 
ATOM   3116 C CZ3 . TRP A 1 569 ? 132.434 152.592 167.976 1.00 24.75  ?  558 TRP A CZ3 1 
ATOM   3117 C CH2 . TRP A 1 569 ? 132.614 153.410 166.864 1.00 24.75  ?  558 TRP A CH2 1 
ATOM   3118 N N   . ASP A 1 570 ? 130.554 147.808 165.316 1.00 31.60  ?  559 ASP A N   1 
ATOM   3119 C CA  . ASP A 1 570 ? 129.545 148.288 164.379 1.00 31.60  ?  559 ASP A CA  1 
ATOM   3120 C C   . ASP A 1 570 ? 128.995 147.182 163.509 1.00 31.60  ?  559 ASP A C   1 
ATOM   3121 O O   . ASP A 1 570 ? 127.827 146.803 163.600 1.00 31.60  ?  559 ASP A O   1 
ATOM   3122 C CB  . ASP A 1 570 ? 130.173 149.369 163.503 1.00 31.60  ?  559 ASP A CB  1 
ATOM   3123 C CG  . ASP A 1 570 ? 129.185 150.100 162.655 1.00 31.60  ?  559 ASP A CG  1 
ATOM   3124 O OD1 . ASP A 1 570 ? 127.967 149.989 162.882 1.00 31.60  ?  559 ASP A OD1 1 
ATOM   3125 O OD2 . ASP A 1 570 ? 129.647 150.819 161.757 1.00 31.60  -1 559 ASP A OD2 1 
ATOM   3126 N N   . GLN A 1 571 ? 129.883 146.651 162.684 1.00 34.70  ?  560 GLN A N   1 
ATOM   3127 C CA  . GLN A 1 571 ? 129.585 145.598 161.729 1.00 34.70  ?  560 GLN A CA  1 
ATOM   3128 C C   . GLN A 1 571 ? 130.756 144.637 161.647 1.00 34.70  ?  560 GLN A C   1 
ATOM   3129 O O   . GLN A 1 571 ? 130.859 143.891 160.668 1.00 34.70  ?  560 GLN A O   1 
ATOM   3130 C CB  . GLN A 1 571 ? 129.276 146.172 160.346 1.00 34.70  ?  560 GLN A CB  1 
ATOM   3131 C CG  . GLN A 1 571 ? 127.877 146.746 160.219 1.00 34.70  ?  560 GLN A CG  1 
ATOM   3132 C CD  . GLN A 1 571 ? 127.542 147.194 158.822 1.00 34.70  ?  560 GLN A CD  1 
ATOM   3133 O OE1 . GLN A 1 571 ? 128.081 146.681 157.853 1.00 34.70  ?  560 GLN A OE1 1 
ATOM   3134 N NE2 . GLN A 1 571 ? 126.642 148.155 158.711 1.00 34.70  ?  560 GLN A NE2 1 
ATOM   3135 N N   . ASN A 1 572 ? 131.657 144.670 162.620 1.00 28.38  ?  561 ASN A N   1 
ATOM   3136 C CA  . ASN A 1 572 ? 132.852 143.858 162.616 1.00 28.38  ?  561 ASN A CA  1 
ATOM   3137 C C   . ASN A 1 572 ? 132.582 142.551 163.336 1.00 28.38  ?  561 ASN A C   1 
ATOM   3138 O O   . ASN A 1 572 ? 131.459 142.266 163.748 1.00 28.38  ?  561 ASN A O   1 
ATOM   3139 C CB  . ASN A 1 572 ? 134.000 144.611 163.269 1.00 28.38  ?  561 ASN A CB  1 
ATOM   3140 C CG  . ASN A 1 572 ? 134.471 145.755 162.448 1.00 28.38  ?  561 ASN A CG  1 
ATOM   3141 O OD1 . ASN A 1 572 ? 135.453 145.655 161.735 1.00 28.38  ?  561 ASN A OD1 1 
ATOM   3142 N ND2 . ASN A 1 572 ? 133.774 146.863 162.540 1.00 28.38  ?  561 ASN A ND2 1 
ATOM   3143 N N   . GLU A 1 573 ? 133.632 141.756 163.503 1.00 35.01  ?  562 GLU A N   1 
ATOM   3144 C CA  . GLU A 1 573 ? 133.540 140.508 164.245 1.00 35.01  ?  562 GLU A CA  1 
ATOM   3145 C C   . GLU A 1 573 ? 133.264 140.784 165.713 1.00 35.01  ?  562 GLU A C   1 
ATOM   3146 O O   . GLU A 1 573 ? 133.902 141.643 166.320 1.00 35.01  ?  562 GLU A O   1 
ATOM   3147 C CB  . GLU A 1 573 ? 134.830 139.722 164.081 1.00 35.01  ?  562 GLU A CB  1 
ATOM   3148 C CG  . GLU A 1 573 ? 134.996 139.142 162.711 1.00 35.01  ?  562 GLU A CG  1 
ATOM   3149 C CD  . GLU A 1 573 ? 136.378 138.578 162.480 1.00 35.01  ?  562 GLU A CD  1 
ATOM   3150 O OE1 . GLU A 1 573 ? 137.273 138.836 163.316 1.00 35.01  ?  562 GLU A OE1 1 
ATOM   3151 O OE2 . GLU A 1 573 ? 136.565 137.875 161.464 1.00 35.01  -1 562 GLU A OE2 1 
ATOM   3152 N N   . ARG A 1 574 ? 132.290 140.083 166.266 1.00 30.54  ?  563 ARG A N   1 
ATOM   3153 C CA  . ARG A 1 574 ? 131.924 140.223 167.659 1.00 30.54  ?  563 ARG A CA  1 
ATOM   3154 C C   . ARG A 1 574 ? 132.547 139.122 168.499 1.00 30.54  ?  563 ARG A C   1 
ATOM   3155 O O   . ARG A 1 574 ? 132.724 137.997 168.044 1.00 30.54  ?  563 ARG A O   1 
ATOM   3156 C CB  . ARG A 1 574 ? 130.423 140.160 167.811 1.00 30.54  ?  563 ARG A CB  1 
ATOM   3157 C CG  . ARG A 1 574 ? 129.708 141.341 167.330 1.00 30.54  ?  563 ARG A CG  1 
ATOM   3158 C CD  . ARG A 1 574 ? 129.067 141.174 165.982 1.00 30.54  ?  563 ARG A CD  1 
ATOM   3159 N NE  . ARG A 1 574 ? 128.185 142.303 165.746 1.00 30.54  ?  563 ARG A NE  1 
ATOM   3160 C CZ  . ARG A 1 574 ? 128.587 143.457 165.238 1.00 30.54  ?  563 ARG A CZ  1 
ATOM   3161 N NH1 . ARG A 1 574 ? 129.851 143.620 164.891 1.00 30.54  1  563 ARG A NH1 1 
ATOM   3162 N NH2 . ARG A 1 574 ? 127.724 144.444 165.087 1.00 30.54  ?  563 ARG A NH2 1 
ATOM   3163 N N   . PHE A 1 575 ? 132.827 139.439 169.758 1.00 22.82  ?  564 PHE A N   1 
ATOM   3164 C CA  . PHE A 1 575 ? 133.510 138.528 170.661 1.00 22.82  ?  564 PHE A CA  1 
ATOM   3165 C C   . PHE A 1 575 ? 132.623 138.199 171.841 1.00 22.82  ?  564 PHE A C   1 
ATOM   3166 O O   . PHE A 1 575 ? 131.979 139.077 172.402 1.00 22.82  ?  564 PHE A O   1 
ATOM   3167 C CB  . PHE A 1 575 ? 134.799 139.124 171.156 1.00 22.82  ?  564 PHE A CB  1 
ATOM   3168 C CG  . PHE A 1 575 ? 135.846 139.188 170.124 1.00 22.82  ?  564 PHE A CG  1 
ATOM   3169 C CD1 . PHE A 1 575 ? 136.692 138.123 169.923 1.00 22.82  ?  564 PHE A CD1 1 
ATOM   3170 C CD2 . PHE A 1 575 ? 135.980 140.303 169.339 1.00 22.82  ?  564 PHE A CD2 1 
ATOM   3171 C CE1 . PHE A 1 575 ? 137.668 138.173 168.966 1.00 22.82  ?  564 PHE A CE1 1 
ATOM   3172 C CE2 . PHE A 1 575 ? 136.952 140.357 168.378 1.00 22.82  ?  564 PHE A CE2 1 
ATOM   3173 C CZ  . PHE A 1 575 ? 137.792 139.280 168.194 1.00 22.82  ?  564 PHE A CZ  1 
ATOM   3174 N N   . LEU A 1 576 ? 132.613 136.937 172.225 1.00 23.88  ?  565 LEU A N   1 
ATOM   3175 C CA  . LEU A 1 576 ? 131.901 136.482 173.401 1.00 23.88  ?  565 LEU A CA  1 
ATOM   3176 C C   . LEU A 1 576 ? 132.912 135.875 174.353 1.00 23.88  ?  565 LEU A C   1 
ATOM   3177 O O   . LEU A 1 576 ? 133.701 135.022 173.952 1.00 23.88  ?  565 LEU A O   1 
ATOM   3178 C CB  . LEU A 1 576 ? 130.838 135.458 173.041 1.00 23.88  ?  565 LEU A CB  1 
ATOM   3179 C CG  . LEU A 1 576 ? 130.119 134.896 174.252 1.00 23.88  ?  565 LEU A CG  1 
ATOM   3180 C CD1 . LEU A 1 576 ? 129.248 135.945 174.856 1.00 23.88  ?  565 LEU A CD1 1 
ATOM   3181 C CD2 . LEU A 1 576 ? 129.322 133.716 173.869 1.00 23.88  ?  565 LEU A CD2 1 
ATOM   3182 N N   . VAL A 1 577 ? 132.909 136.327 175.601 1.00 22.04  ?  566 VAL A N   1 
ATOM   3183 C CA  . VAL A 1 577 ? 133.824 135.839 176.627 1.00 22.04  ?  566 VAL A CA  1 
ATOM   3184 C C   . VAL A 1 577 ? 132.990 135.221 177.730 1.00 22.04  ?  566 VAL A C   1 
ATOM   3185 O O   . VAL A 1 577 ? 132.096 135.876 178.268 1.00 22.04  ?  566 VAL A O   1 
ATOM   3186 C CB  . VAL A 1 577 ? 134.711 136.962 177.185 1.00 22.04  ?  566 VAL A CB  1 
ATOM   3187 C CG1 . VAL A 1 577 ? 135.632 136.426 178.240 1.00 22.04  ?  566 VAL A CG1 1 
ATOM   3188 C CG2 . VAL A 1 577 ? 135.479 137.615 176.086 1.00 22.04  ?  566 VAL A CG2 1 
ATOM   3189 N N   . VAL A 1 578 ? 133.266 133.963 178.056 1.00 29.46  ?  567 VAL A N   1 
ATOM   3190 C CA  . VAL A 1 578 ? 132.614 133.265 179.157 1.00 29.46  ?  567 VAL A CA  1 
ATOM   3191 C C   . VAL A 1 578 ? 133.701 132.766 180.095 1.00 29.46  ?  567 VAL A C   1 
ATOM   3192 O O   . VAL A 1 578 ? 134.646 132.112 179.653 1.00 29.46  ?  567 VAL A O   1 
ATOM   3193 C CB  . VAL A 1 578 ? 131.727 132.106 178.657 1.00 29.46  ?  567 VAL A CB  1 
ATOM   3194 C CG1 . VAL A 1 578 ? 131.185 131.311 179.807 1.00 29.46  ?  567 VAL A CG1 1 
ATOM   3195 C CG2 . VAL A 1 578 ? 130.577 132.636 177.840 1.00 29.46  ?  567 VAL A CG2 1 
ATOM   3196 N N   . LEU A 1 579 ? 133.582 133.108 181.376 1.00 29.66  ?  568 LEU A N   1 
ATOM   3197 C CA  . LEU A 1 579 ? 134.592 132.837 182.388 1.00 29.66  ?  568 LEU A CA  1 
ATOM   3198 C C   . LEU A 1 579 ? 133.956 132.098 183.551 1.00 29.66  ?  568 LEU A C   1 
ATOM   3199 O O   . LEU A 1 579 ? 132.816 132.380 183.913 1.00 29.66  ?  568 LEU A O   1 
ATOM   3200 C CB  . LEU A 1 579 ? 135.208 134.127 182.908 1.00 29.66  ?  568 LEU A CB  1 
ATOM   3201 C CG  . LEU A 1 579 ? 135.792 135.141 181.939 1.00 29.66  ?  568 LEU A CG  1 
ATOM   3202 C CD1 . LEU A 1 579 ? 135.882 136.465 182.617 1.00 29.66  ?  568 LEU A CD1 1 
ATOM   3203 C CD2 . LEU A 1 579 ? 137.131 134.700 181.528 1.00 29.66  ?  568 LEU A CD2 1 
ATOM   3204 N N   . ASN A 1 580 ? 134.698 131.178 184.155 1.00 44.21  ?  569 ASN A N   1 
ATOM   3205 C CA  . ASN A 1 580 ? 134.179 130.351 185.243 1.00 44.21  ?  569 ASN A CA  1 
ATOM   3206 C C   . ASN A 1 580 ? 135.060 130.509 186.474 1.00 44.21  ?  569 ASN A C   1 
ATOM   3207 O O   . ASN A 1 580 ? 136.125 129.899 186.565 1.00 44.21  ?  569 ASN A O   1 
ATOM   3208 C CB  . ASN A 1 580 ? 134.094 128.894 184.821 1.00 44.21  ?  569 ASN A CB  1 
ATOM   3209 C CG  . ASN A 1 580 ? 133.452 128.025 185.869 1.00 44.21  ?  569 ASN A CG  1 
ATOM   3210 O OD1 . ASN A 1 580 ? 132.731 128.501 186.733 1.00 44.21  ?  569 ASN A OD1 1 
ATOM   3211 N ND2 . ASN A 1 580 ? 133.703 126.736 185.791 1.00 44.21  ?  569 ASN A ND2 1 
ATOM   3212 N N   . PHE A 1 581 ? 134.609 131.312 187.427 1.00 44.69  ?  570 PHE A N   1 
ATOM   3213 C CA  . PHE A 1 581 ? 135.314 131.512 188.689 1.00 44.69  ?  570 PHE A CA  1 
ATOM   3214 C C   . PHE A 1 581 ? 134.824 130.538 189.760 1.00 44.69  ?  570 PHE A C   1 
ATOM   3215 O O   . PHE A 1 581 ? 134.460 130.945 190.860 1.00 44.69  ?  570 PHE A O   1 
ATOM   3216 C CB  . PHE A 1 581 ? 135.130 132.947 189.162 1.00 44.69  ?  570 PHE A CB  1 
ATOM   3217 C CG  . PHE A 1 581 ? 135.834 133.973 188.334 1.00 44.69  ?  570 PHE A CG  1 
ATOM   3218 C CD1 . PHE A 1 581 ? 137.185 134.179 188.476 1.00 44.69  ?  570 PHE A CD1 1 
ATOM   3219 C CD2 . PHE A 1 581 ? 135.129 134.781 187.466 1.00 44.69  ?  570 PHE A CD2 1 
ATOM   3220 C CE1 . PHE A 1 581 ? 137.826 135.141 187.733 1.00 44.69  ?  570 PHE A CE1 1 
ATOM   3221 C CE2 . PHE A 1 581 ? 135.767 135.743 186.727 1.00 44.69  ?  570 PHE A CE2 1 
ATOM   3222 C CZ  . PHE A 1 581 ? 137.111 135.922 186.861 1.00 44.69  ?  570 PHE A CZ  1 
ATOM   3223 N N   . GLY A 1 582 ? 134.814 129.249 189.463 1.00 56.96  ?  571 GLY A N   1 
ATOM   3224 C CA  . GLY A 1 582 ? 134.221 128.276 190.361 1.00 56.96  ?  571 GLY A CA  1 
ATOM   3225 C C   . GLY A 1 582 ? 134.998 126.980 190.365 1.00 56.96  ?  571 GLY A C   1 
ATOM   3226 O O   . GLY A 1 582 ? 135.623 126.601 189.374 1.00 56.96  ?  571 GLY A O   1 
ATOM   3227 N N   . ASP A 1 583 ? 134.969 126.308 191.511 1.00 68.85  ?  572 ASP A N   1 
ATOM   3228 C CA  . ASP A 1 583 ? 135.663 125.033 191.683 1.00 68.85  ?  572 ASP A CA  1 
ATOM   3229 C C   . ASP A 1 583 ? 134.749 123.835 191.443 1.00 68.85  ?  572 ASP A C   1 
ATOM   3230 O O   . ASP A 1 583 ? 134.849 122.825 192.132 1.00 68.85  ?  572 ASP A O   1 
ATOM   3231 C CB  . ASP A 1 583 ? 136.227 124.987 193.092 1.00 68.85  ?  572 ASP A CB  1 
ATOM   3232 C CG  . ASP A 1 583 ? 135.175 125.305 194.122 1.00 68.85  ?  572 ASP A CG  1 
ATOM   3233 O OD1 . ASP A 1 583 ? 134.179 125.959 193.752 1.00 68.85  ?  572 ASP A OD1 1 
ATOM   3234 O OD2 . ASP A 1 583 ? 135.331 124.907 195.292 1.00 68.85  -1 572 ASP A OD2 1 
ATOM   3235 N N   . VAL A 1 584 ? 133.921 123.905 190.403 1.00 66.61  ?  573 VAL A N   1 
ATOM   3236 C CA  . VAL A 1 584 ? 132.873 122.929 190.113 1.00 66.61  ?  573 VAL A CA  1 
ATOM   3237 C C   . VAL A 1 584 ? 132.552 123.019 188.633 1.00 66.61  ?  573 VAL A C   1 
ATOM   3238 O O   . VAL A 1 584 ? 132.781 124.055 188.004 1.00 66.61  ?  573 VAL A O   1 
ATOM   3239 C CB  . VAL A 1 584 ? 131.578 123.167 190.926 1.00 66.61  ?  573 VAL A CB  1 
ATOM   3240 C CG1 . VAL A 1 584 ? 131.653 122.641 192.366 1.00 66.61  ?  573 VAL A CG1 1 
ATOM   3241 C CG2 . VAL A 1 584 ? 131.240 124.654 190.924 1.00 66.61  ?  573 VAL A CG2 1 
ATOM   3242 N N   . GLY A 1 585 ? 131.998 121.945 188.080 1.00 69.88  ?  574 GLY A N   1 
ATOM   3243 C CA  . GLY A 1 585 ? 131.625 121.950 186.675 1.00 69.88  ?  574 GLY A CA  1 
ATOM   3244 C C   . GLY A 1 585 ? 130.398 122.812 186.440 1.00 69.88  ?  574 GLY A C   1 
ATOM   3245 O O   . GLY A 1 585 ? 129.486 122.861 187.272 1.00 69.88  ?  574 GLY A O   1 
ATOM   3246 N N   . LEU A 1 586 ? 130.378 123.515 185.310 1.00 67.52  ?  575 LEU A N   1 
ATOM   3247 C CA  . LEU A 1 586 ? 129.268 124.392 184.968 1.00 67.52  ?  575 LEU A CA  1 
ATOM   3248 C C   . LEU A 1 586 ? 128.803 124.157 183.540 1.00 67.52  ?  575 LEU A C   1 
ATOM   3249 O O   . LEU A 1 586 ? 129.611 123.985 182.624 1.00 67.52  ?  575 LEU A O   1 
ATOM   3250 C CB  . LEU A 1 586 ? 129.620 125.878 185.122 1.00 67.52  ?  575 LEU A CB  1 
ATOM   3251 C CG  . LEU A 1 586 ? 129.329 126.610 186.437 1.00 67.52  ?  575 LEU A CG  1 
ATOM   3252 C CD1 . LEU A 1 586 ? 127.839 126.526 186.776 1.00 67.52  ?  575 LEU A CD1 1 
ATOM   3253 C CD2 . LEU A 1 586 ? 130.176 126.135 187.591 1.00 67.52  ?  575 LEU A CD2 1 
ATOM   3254 N N   . SER A 1 587 ? 127.489 124.129 183.373 1.00 69.43  ?  576 SER A N   1 
ATOM   3255 C CA  . SER A 1 587 ? 126.880 124.378 182.081 1.00 69.43  ?  576 SER A CA  1 
ATOM   3256 C C   . SER A 1 587 ? 126.407 125.823 182.064 1.00 69.43  ?  576 SER A C   1 
ATOM   3257 O O   . SER A 1 587 ? 125.814 126.295 183.038 1.00 69.43  ?  576 SER A O   1 
ATOM   3258 C CB  . SER A 1 587 ? 125.725 123.411 181.831 1.00 69.43  ?  576 SER A CB  1 
ATOM   3259 O OG  . SER A 1 587 ? 124.666 123.624 182.746 1.00 69.43  ?  576 SER A OG  1 
ATOM   3260 N N   . ALA A 1 588 ? 126.675 126.527 180.963 1.00 68.89  ?  577 ALA A N   1 
ATOM   3261 C CA  . ALA A 1 588 ? 126.563 127.982 180.970 1.00 68.89  ?  577 ALA A CA  1 
ATOM   3262 C C   . ALA A 1 588 ? 125.112 128.438 180.905 1.00 68.89  ?  577 ALA A C   1 
ATOM   3263 O O   . ALA A 1 588 ? 124.609 129.071 181.840 1.00 68.89  ?  577 ALA A O   1 
ATOM   3264 C CB  . ALA A 1 588 ? 127.366 128.572 179.812 1.00 68.89  ?  577 ALA A CB  1 
ATOM   3265 N N   . GLY A 1 589 ? 124.417 128.117 179.818 1.00 66.24  ?  578 GLY A N   1 
ATOM   3266 C CA  . GLY A 1 589 ? 123.040 128.550 179.662 1.00 66.24  ?  578 GLY A CA  1 
ATOM   3267 C C   . GLY A 1 589 ? 122.882 130.051 179.524 1.00 66.24  ?  578 GLY A C   1 
ATOM   3268 O O   . GLY A 1 589 ? 122.382 130.708 180.438 1.00 66.24  ?  578 GLY A O   1 
ATOM   3269 N N   . LEU A 1 590 ? 123.322 130.603 178.397 1.00 63.21  ?  579 LEU A N   1 
ATOM   3270 C CA  . LEU A 1 590 ? 123.459 132.051 178.242 1.00 63.21  ?  579 LEU A CA  1 
ATOM   3271 C C   . LEU A 1 590 ? 122.083 132.676 178.072 1.00 63.21  ?  579 LEU A C   1 
ATOM   3272 O O   . LEU A 1 590 ? 121.580 132.851 176.964 1.00 63.21  ?  579 LEU A O   1 
ATOM   3273 C CB  . LEU A 1 590 ? 124.383 132.375 177.076 1.00 63.21  ?  579 LEU A CB  1 
ATOM   3274 C CG  . LEU A 1 590 ? 125.813 131.906 177.344 1.00 63.21  ?  579 LEU A CG  1 
ATOM   3275 C CD1 . LEU A 1 590 ? 126.715 132.143 176.161 1.00 63.21  ?  579 LEU A CD1 1 
ATOM   3276 C CD2 . LEU A 1 590 ? 126.351 132.612 178.561 1.00 63.21  ?  579 LEU A CD2 1 
ATOM   3277 N N   . GLN A 1 591 ? 121.497 133.061 179.205 1.00 71.31  ?  580 GLN A N   1 
ATOM   3278 C CA  . GLN A 1 591 ? 120.161 133.649 179.271 1.00 71.31  ?  580 GLN A CA  1 
ATOM   3279 C C   . GLN A 1 591 ? 120.286 135.132 178.928 1.00 71.31  ?  580 GLN A C   1 
ATOM   3280 O O   . GLN A 1 591 ? 120.180 136.007 179.788 1.00 71.31  ?  580 GLN A O   1 
ATOM   3281 C CB  . GLN A 1 591 ? 119.582 133.445 180.667 1.00 71.31  ?  580 GLN A CB  1 
ATOM   3282 C CG  . GLN A 1 591 ? 118.124 133.818 180.860 1.00 71.31  ?  580 GLN A CG  1 
ATOM   3283 C CD  . GLN A 1 591 ? 117.754 133.854 182.327 1.00 71.31  ?  580 GLN A CD  1 
ATOM   3284 O OE1 . GLN A 1 591 ? 118.605 133.652 183.192 1.00 71.31  ?  580 GLN A OE1 1 
ATOM   3285 N NE2 . GLN A 1 591 ? 116.487 134.132 182.617 1.00 71.31  ?  580 GLN A NE2 1 
ATOM   3286 N N   . ALA A 1 592 ? 120.580 135.414 177.657 1.00 74.38  ?  581 ALA A N   1 
ATOM   3287 C CA  . ALA A 1 592 ? 120.839 136.795 177.276 1.00 74.38  ?  581 ALA A CA  1 
ATOM   3288 C C   . ALA A 1 592 ? 119.607 137.689 177.355 1.00 74.38  ?  581 ALA A C   1 
ATOM   3289 O O   . ALA A 1 592 ? 119.441 138.445 178.320 1.00 74.38  ?  581 ALA A O   1 
ATOM   3290 C CB  . ALA A 1 592 ? 121.401 136.836 175.858 1.00 74.38  ?  581 ALA A CB  1 
ATOM   3291 N N   . SER A 1 593 ? 118.731 137.591 176.352 1.00 81.96  ?  582 SER A N   1 
ATOM   3292 C CA  . SER A 1 593 ? 117.376 138.150 176.281 1.00 81.96  ?  582 SER A CA  1 
ATOM   3293 C C   . SER A 1 593 ? 117.289 139.672 176.451 1.00 81.96  ?  582 SER A C   1 
ATOM   3294 O O   . SER A 1 593 ? 116.196 140.232 176.319 1.00 81.96  ?  582 SER A O   1 
ATOM   3295 C CB  . SER A 1 593 ? 116.449 137.471 177.290 1.00 81.96  ?  582 SER A CB  1 
ATOM   3296 O OG  . SER A 1 593 ? 116.258 136.113 176.938 1.00 81.96  ?  582 SER A OG  1 
ATOM   3297 N N   . ASP A 1 594 ? 118.409 140.374 176.676 1.00 80.55  ?  583 ASP A N   1 
ATOM   3298 C CA  . ASP A 1 594 ? 118.409 141.804 176.959 1.00 80.55  ?  583 ASP A CA  1 
ATOM   3299 C C   . ASP A 1 594 ? 119.479 142.528 176.155 1.00 80.55  ?  583 ASP A C   1 
ATOM   3300 O O   . ASP A 1 594 ? 119.710 143.723 176.379 1.00 80.55  ?  583 ASP A O   1 
ATOM   3301 C CB  . ASP A 1 594 ? 118.646 142.105 178.448 1.00 80.55  ?  583 ASP A CB  1 
ATOM   3302 C CG  . ASP A 1 594 ? 117.379 142.029 179.288 1.00 80.55  ?  583 ASP A CG  1 
ATOM   3303 O OD1 . ASP A 1 594 ? 116.401 141.379 178.876 1.00 80.55  ?  583 ASP A OD1 1 
ATOM   3304 O OD2 . ASP A 1 594 ? 117.357 142.644 180.374 1.00 80.55  -1 583 ASP A OD2 1 
ATOM   3305 N N   . LEU A 1 595 ? 120.138 141.835 175.238 1.00 67.20  ?  584 LEU A N   1 
ATOM   3306 C CA  . LEU A 1 595 ? 121.214 142.422 174.473 1.00 67.20  ?  584 LEU A CA  1 
ATOM   3307 C C   . LEU A 1 595 ? 120.655 143.427 173.471 1.00 67.20  ?  584 LEU A C   1 
ATOM   3308 O O   . LEU A 1 595 ? 119.449 143.451 173.218 1.00 67.20  ?  584 LEU A O   1 
ATOM   3309 C CB  . LEU A 1 595 ? 121.994 141.314 173.769 1.00 67.20  ?  584 LEU A CB  1 
ATOM   3310 C CG  . LEU A 1 595 ? 122.946 140.552 174.686 1.00 67.20  ?  584 LEU A CG  1 
ATOM   3311 C CD1 . LEU A 1 595 ? 123.688 139.475 173.922 1.00 67.20  ?  584 LEU A CD1 1 
ATOM   3312 C CD2 . LEU A 1 595 ? 123.913 141.509 175.343 1.00 67.20  ?  584 LEU A CD2 1 
ATOM   3313 N N   . PRO A 1 596 ? 121.495 144.306 172.922 1.00 61.27  ?  585 PRO A N   1 
ATOM   3314 C CA  . PRO A 1 596 ? 121.032 145.122 171.800 1.00 61.27  ?  585 PRO A CA  1 
ATOM   3315 C C   . PRO A 1 596 ? 120.790 144.255 170.578 1.00 61.27  ?  585 PRO A C   1 
ATOM   3316 O O   . PRO A 1 596 ? 121.330 143.155 170.447 1.00 61.27  ?  585 PRO A O   1 
ATOM   3317 C CB  . PRO A 1 596 ? 122.183 146.104 171.571 1.00 61.27  ?  585 PRO A CB  1 
ATOM   3318 C CG  . PRO A 1 596 ? 122.887 146.157 172.859 1.00 61.27  ?  585 PRO A CG  1 
ATOM   3319 C CD  . PRO A 1 596 ? 122.796 144.789 173.422 1.00 61.27  ?  585 PRO A CD  1 
ATOM   3320 N N   . ALA A 1 597 ? 119.949 144.771 169.680 1.00 64.51  ?  586 ALA A N   1 
ATOM   3321 C CA  . ALA A 1 597 ? 119.623 144.068 168.446 1.00 64.51  ?  586 ALA A CA  1 
ATOM   3322 C C   . ALA A 1 597 ? 120.822 143.945 167.517 1.00 64.51  ?  586 ALA A C   1 
ATOM   3323 O O   . ALA A 1 597 ? 120.878 143.009 166.714 1.00 64.51  ?  586 ALA A O   1 
ATOM   3324 C CB  . ALA A 1 597 ? 118.481 144.790 167.735 1.00 64.51  ?  586 ALA A CB  1 
ATOM   3325 N N   . SER A 1 598 ? 121.785 144.856 167.623 1.00 64.08  ?  587 SER A N   1 
ATOM   3326 C CA  . SER A 1 598 ? 123.010 144.801 166.841 1.00 64.08  ?  587 SER A CA  1 
ATOM   3327 C C   . SER A 1 598 ? 123.982 143.736 167.320 1.00 64.08  ?  587 SER A C   1 
ATOM   3328 O O   . SER A 1 598 ? 124.946 143.437 166.607 1.00 64.08  ?  587 SER A O   1 
ATOM   3329 C CB  . SER A 1 598 ? 123.700 146.157 166.888 1.00 64.08  ?  587 SER A CB  1 
ATOM   3330 O OG  . SER A 1 598 ? 124.036 146.467 168.227 1.00 64.08  ?  587 SER A OG  1 
ATOM   3331 N N   . ALA A 1 599 ? 123.760 143.166 168.498 1.00 60.61  ?  588 ALA A N   1 
ATOM   3332 C CA  . ALA A 1 599 ? 124.662 142.198 169.099 1.00 60.61  ?  588 ALA A CA  1 
ATOM   3333 C C   . ALA A 1 599 ? 123.889 141.034 169.702 1.00 60.61  ?  588 ALA A C   1 
ATOM   3334 O O   . ALA A 1 599 ? 124.220 140.536 170.777 1.00 60.61  ?  588 ALA A O   1 
ATOM   3335 C CB  . ALA A 1 599 ? 125.515 142.868 170.164 1.00 60.61  ?  588 ALA A CB  1 
ATOM   3336 N N   . SER A 1 600 ? 122.841 140.577 169.030 1.00 64.41  ?  589 SER A N   1 
ATOM   3337 C CA  . SER A 1 600 ? 122.121 139.427 169.551 1.00 64.41  ?  589 SER A CA  1 
ATOM   3338 C C   . SER A 1 600 ? 122.894 138.155 169.245 1.00 64.41  ?  589 SER A C   1 
ATOM   3339 O O   . SER A 1 600 ? 123.703 138.104 168.315 1.00 64.41  ?  589 SER A O   1 
ATOM   3340 C CB  . SER A 1 600 ? 120.709 139.351 168.977 1.00 64.41  ?  589 SER A CB  1 
ATOM   3341 O OG  . SER A 1 600 ? 119.911 140.411 169.471 1.00 64.41  ?  589 SER A OG  1 
ATOM   3342 N N   . LEU A 1 601 ? 122.649 137.128 170.047 1.00 63.79  ?  590 LEU A N   1 
ATOM   3343 C CA  . LEU A 1 601 ? 123.505 135.955 170.011 1.00 63.79  ?  590 LEU A CA  1 
ATOM   3344 C C   . LEU A 1 601 ? 123.071 135.002 168.902 1.00 63.79  ?  590 LEU A C   1 
ATOM   3345 O O   . LEU A 1 601 ? 121.877 134.755 168.722 1.00 63.79  ?  590 LEU A O   1 
ATOM   3346 C CB  . LEU A 1 601 ? 123.473 135.238 171.346 1.00 63.79  ?  590 LEU A CB  1 
ATOM   3347 C CG  . LEU A 1 601 ? 124.341 135.880 172.422 1.00 63.79  ?  590 LEU A CG  1 
ATOM   3348 C CD1 . LEU A 1 601 ? 124.109 135.207 173.756 1.00 63.79  ?  590 LEU A CD1 1 
ATOM   3349 C CD2 . LEU A 1 601 ? 125.819 135.838 172.026 1.00 63.79  ?  590 LEU A CD2 1 
ATOM   3350 N N   . PRO A 1 602 ? 124.018 134.442 168.154 1.00 63.31  ?  591 PRO A N   1 
ATOM   3351 C CA  . PRO A 1 602 ? 123.662 133.410 167.177 1.00 63.31  ?  591 PRO A CA  1 
ATOM   3352 C C   . PRO A 1 602 ? 123.412 132.070 167.847 1.00 63.31  ?  591 PRO A C   1 
ATOM   3353 O O   . PRO A 1 602 ? 123.412 131.968 169.076 1.00 63.31  ?  591 PRO A O   1 
ATOM   3354 C CB  . PRO A 1 602 ? 124.889 133.362 166.265 1.00 63.31  ?  591 PRO A CB  1 
ATOM   3355 C CG  . PRO A 1 602 ? 126.002 133.765 167.144 1.00 63.31  ?  591 PRO A CG  1 
ATOM   3356 C CD  . PRO A 1 602 ? 125.445 134.796 168.080 1.00 63.31  ?  591 PRO A CD  1 
ATOM   3357 N N   . ALA A 1 603 ? 123.183 131.032 167.053 1.00 65.65  ?  592 ALA A N   1 
ATOM   3358 C CA  . ALA A 1 603 ? 123.034 129.695 167.600 1.00 65.65  ?  592 ALA A CA  1 
ATOM   3359 C C   . ALA A 1 603 ? 124.356 128.961 167.710 1.00 65.65  ?  592 ALA A C   1 
ATOM   3360 O O   . ALA A 1 603 ? 124.470 128.037 168.522 1.00 65.65  ?  592 ALA A O   1 
ATOM   3361 C CB  . ALA A 1 603 ? 122.074 128.880 166.735 1.00 65.65  ?  592 ALA A CB  1 
ATOM   3362 N N   . LYS A 1 604 ? 125.341 129.342 166.905 1.00 67.18  ?  593 LYS A N   1 
ATOM   3363 C CA  . LYS A 1 604 ? 126.622 128.662 166.819 1.00 67.18  ?  593 LYS A CA  1 
ATOM   3364 C C   . LYS A 1 604 ? 127.730 129.688 166.609 1.00 67.18  ?  593 LYS A C   1 
ATOM   3365 O O   . LYS A 1 604 ? 127.591 130.601 165.793 1.00 67.18  ?  593 LYS A O   1 
ATOM   3366 C CB  . LYS A 1 604 ? 126.583 127.639 165.684 1.00 67.18  ?  593 LYS A CB  1 
ATOM   3367 C CG  . LYS A 1 604 ? 127.877 126.928 165.414 1.00 67.18  ?  593 LYS A CG  1 
ATOM   3368 C CD  . LYS A 1 604 ? 127.673 125.758 164.471 1.00 67.18  ?  593 LYS A CD  1 
ATOM   3369 C CE  . LYS A 1 604 ? 127.258 126.214 163.086 1.00 67.18  ?  593 LYS A CE  1 
ATOM   3370 N NZ  . LYS A 1 604 ? 128.340 126.982 162.413 1.00 67.18  1  593 LYS A NZ  1 
ATOM   3371 N N   . ALA A 1 605 ? 128.828 129.541 167.350 1.00 58.64  ?  594 ALA A N   1 
ATOM   3372 C CA  . ALA A 1 605 ? 129.938 130.479 167.282 1.00 58.64  ?  594 ALA A CA  1 
ATOM   3373 C C   . ALA A 1 605 ? 131.261 129.732 167.284 1.00 58.64  ?  594 ALA A C   1 
ATOM   3374 O O   . ALA A 1 605 ? 131.366 128.620 167.797 1.00 58.64  ?  594 ALA A O   1 
ATOM   3375 C CB  . ALA A 1 605 ? 129.906 131.470 168.443 1.00 58.64  ?  594 ALA A CB  1 
ATOM   3376 N N   . ASP A 1 606 ? 132.291 130.385 166.746 1.00 52.15  ?  595 ASP A N   1 
ATOM   3377 C CA  . ASP A 1 606 ? 133.615 129.787 166.611 1.00 52.15  ?  595 ASP A CA  1 
ATOM   3378 C C   . ASP A 1 606 ? 134.344 129.658 167.941 1.00 52.15  ?  595 ASP A C   1 
ATOM   3379 O O   . ASP A 1 606 ? 133.749 129.781 169.014 1.00 52.15  ?  595 ASP A O   1 
ATOM   3380 C CB  . ASP A 1 606 ? 134.492 130.612 165.672 1.00 52.15  ?  595 ASP A CB  1 
ATOM   3381 C CG  . ASP A 1 606 ? 134.032 130.558 164.232 1.00 52.15  ?  595 ASP A CG  1 
ATOM   3382 O OD1 . ASP A 1 606 ? 133.453 129.527 163.829 1.00 52.15  ?  595 ASP A OD1 1 
ATOM   3383 O OD2 . ASP A 1 606 ? 134.249 131.546 163.496 1.00 52.15  -1 595 ASP A OD2 1 
ATOM   3384 N N   . LEU A 1 607 ? 135.641 129.395 167.883 1.00 45.62  ?  596 LEU A N   1 
ATOM   3385 C CA  . LEU A 1 607 ? 136.471 129.457 169.069 1.00 45.62  ?  596 LEU A CA  1 
ATOM   3386 C C   . LEU A 1 607 ? 137.782 130.131 168.702 1.00 45.62  ?  596 LEU A C   1 
ATOM   3387 O O   . LEU A 1 607 ? 138.266 129.983 167.580 1.00 45.62  ?  596 LEU A O   1 
ATOM   3388 C CB  . LEU A 1 607 ? 136.723 128.071 169.648 1.00 45.62  ?  596 LEU A CB  1 
ATOM   3389 C CG  . LEU A 1 607 ? 137.087 128.049 171.128 1.00 45.62  ?  596 LEU A CG  1 
ATOM   3390 C CD1 . LEU A 1 607 ? 135.847 128.153 171.939 1.00 45.62  ?  596 LEU A CD1 1 
ATOM   3391 C CD2 . LEU A 1 607 ? 137.840 126.801 171.518 1.00 45.62  ?  596 LEU A CD2 1 
ATOM   3392 N N   . LEU A 1 608 ? 138.324 130.916 169.626 1.00 41.34  ?  597 LEU A N   1 
ATOM   3393 C CA  . LEU A 1 608 ? 139.683 131.417 169.479 1.00 41.34  ?  597 LEU A CA  1 
ATOM   3394 C C   . LEU A 1 608 ? 140.667 130.687 170.374 1.00 41.34  ?  597 LEU A C   1 
ATOM   3395 O O   . LEU A 1 608 ? 141.761 130.351 169.916 1.00 41.34  ?  597 LEU A O   1 
ATOM   3396 C CB  . LEU A 1 608 ? 139.775 132.923 169.758 1.00 41.34  ?  597 LEU A CB  1 
ATOM   3397 C CG  . LEU A 1 608 ? 139.746 133.904 168.596 1.00 41.34  ?  597 LEU A CG  1 
ATOM   3398 C CD1 . LEU A 1 608 ? 140.964 133.709 167.740 1.00 41.34  ?  597 LEU A CD1 1 
ATOM   3399 C CD2 . LEU A 1 608 ? 138.514 133.719 167.789 1.00 41.34  ?  597 LEU A CD2 1 
ATOM   3400 N N   . LEU A 1 609 ? 140.306 130.456 171.632 1.00 38.45  ?  598 LEU A N   1 
ATOM   3401 C CA  . LEU A 1 609 ? 141.181 129.797 172.590 1.00 38.45  ?  598 LEU A CA  1 
ATOM   3402 C C   . LEU A 1 609 ? 140.363 129.355 173.792 1.00 38.45  ?  598 LEU A C   1 
ATOM   3403 O O   . LEU A 1 609 ? 139.181 129.672 173.919 1.00 38.45  ?  598 LEU A O   1 
ATOM   3404 C CB  . LEU A 1 609 ? 142.353 130.700 173.000 1.00 38.45  ?  598 LEU A CB  1 
ATOM   3405 C CG  . LEU A 1 609 ? 142.219 132.133 173.500 1.00 38.45  ?  598 LEU A CG  1 
ATOM   3406 C CD1 . LEU A 1 609 ? 142.022 132.197 174.991 1.00 38.45  ?  598 LEU A CD1 1 
ATOM   3407 C CD2 . LEU A 1 609 ? 143.458 132.872 173.097 1.00 38.45  ?  598 LEU A CD2 1 
ATOM   3408 N N   . SER A 1 610 ? 141.008 128.565 174.647 1.00 41.34  ?  599 SER A N   1 
ATOM   3409 C CA  . SER A 1 610 ? 140.550 128.279 175.993 1.00 41.34  ?  599 SER A CA  1 
ATOM   3410 C C   . SER A 1 610 ? 141.763 128.291 176.899 1.00 41.34  ?  599 SER A C   1 
ATOM   3411 O O   . SER A 1 610 ? 142.904 128.266 176.440 1.00 41.34  ?  599 SER A O   1 
ATOM   3412 C CB  . SER A 1 610 ? 139.815 126.944 176.104 1.00 41.34  ?  599 SER A CB  1 
ATOM   3413 O OG  . SER A 1 610 ? 138.551 127.003 175.481 1.00 41.34  ?  599 SER A OG  1 
ATOM   3414 N N   . THR A 1 611 ? 141.507 128.357 178.195 1.00 45.38  ?  600 THR A N   1 
ATOM   3415 C CA  . THR A 1 611 ? 142.604 128.411 179.145 1.00 45.38  ?  600 THR A CA  1 
ATOM   3416 C C   . THR A 1 611 ? 143.123 127.024 179.476 1.00 45.38  ?  600 THR A C   1 
ATOM   3417 O O   . THR A 1 611 ? 144.286 126.878 179.864 1.00 45.38  ?  600 THR A O   1 
ATOM   3418 C CB  . THR A 1 611 ? 142.165 129.126 180.422 1.00 45.38  ?  600 THR A CB  1 
ATOM   3419 O OG1 . THR A 1 611 ? 141.068 128.420 181.006 1.00 45.38  ?  600 THR A OG1 1 
ATOM   3420 C CG2 . THR A 1 611 ? 141.718 130.535 180.117 1.00 45.38  ?  600 THR A CG2 1 
ATOM   3421 N N   . GLN A 1 612 ? 142.294 126.014 179.331 1.00 56.61  ?  601 GLN A N   1 
ATOM   3422 C CA  . GLN A 1 612 ? 142.630 124.657 179.688 1.00 56.61  ?  601 GLN A CA  1 
ATOM   3423 C C   . GLN A 1 612 ? 142.578 123.753 178.466 1.00 56.61  ?  601 GLN A C   1 
ATOM   3424 O O   . GLN A 1 612 ? 141.757 123.979 177.571 1.00 56.61  ?  601 GLN A O   1 
ATOM   3425 C CB  . GLN A 1 612 ? 141.665 124.149 180.760 1.00 56.61  ?  601 GLN A CB  1 
ATOM   3426 C CG  . GLN A 1 612 ? 141.741 124.984 182.001 1.00 56.61  ?  601 GLN A CG  1 
ATOM   3427 C CD  . GLN A 1 612 ? 140.914 124.439 183.110 1.00 56.61  ?  601 GLN A CD  1 
ATOM   3428 O OE1 . GLN A 1 612 ? 140.012 123.646 182.883 1.00 56.61  ?  601 GLN A OE1 1 
ATOM   3429 N NE2 . GLN A 1 612 ? 141.209 124.862 184.332 1.00 56.61  ?  601 GLN A NE2 1 
ATOM   3430 N N   . PRO A 1 613 ? 143.443 122.738 178.386 1.00 70.92  ?  602 PRO A N   1 
ATOM   3431 C CA  . PRO A 1 613 ? 143.452 121.873 177.200 1.00 70.92  ?  602 PRO A CA  1 
ATOM   3432 C C   . PRO A 1 613 ? 142.252 120.941 177.155 1.00 70.92  ?  602 PRO A C   1 
ATOM   3433 O O   . PRO A 1 613 ? 141.610 120.656 178.168 1.00 70.92  ?  602 PRO A O   1 
ATOM   3434 C CB  . PRO A 1 613 ? 144.756 121.086 177.348 1.00 70.92  ?  602 PRO A CB  1 
ATOM   3435 C CG  . PRO A 1 613 ? 144.999 121.058 178.799 1.00 70.92  ?  602 PRO A CG  1 
ATOM   3436 C CD  . PRO A 1 613 ? 144.504 122.365 179.337 1.00 70.92  ?  602 PRO A CD  1 
ATOM   3437 N N   . GLY A 1 614 ? 141.946 120.480 175.950 1.00 75.91  ?  603 GLY A N   1 
ATOM   3438 C CA  . GLY A 1 614 ? 140.832 119.579 175.749 1.00 75.91  ?  603 GLY A CA  1 
ATOM   3439 C C   . GLY A 1 614 ? 140.044 119.938 174.512 1.00 75.91  ?  603 GLY A C   1 
ATOM   3440 O O   . GLY A 1 614 ? 139.218 119.159 174.034 1.00 75.91  ?  603 GLY A O   1 
ATOM   3441 N N   . ARG A 1 615 ? 140.292 121.134 173.989 1.00 67.65  ?  604 ARG A N   1 
ATOM   3442 C CA  . ARG A 1 615 ? 139.613 121.637 172.805 1.00 67.65  ?  604 ARG A CA  1 
ATOM   3443 C C   . ARG A 1 615 ? 140.660 122.068 171.795 1.00 67.65  ?  604 ARG A C   1 
ATOM   3444 O O   . ARG A 1 615 ? 141.792 122.386 172.165 1.00 67.65  ?  604 ARG A O   1 
ATOM   3445 C CB  . ARG A 1 615 ? 138.696 122.830 173.127 1.00 67.65  ?  604 ARG A CB  1 
ATOM   3446 C CG  . ARG A 1 615 ? 138.085 122.826 174.510 1.00 67.65  ?  604 ARG A CG  1 
ATOM   3447 C CD  . ARG A 1 615 ? 136.640 123.270 174.488 1.00 67.65  ?  604 ARG A CD  1 
ATOM   3448 N NE  . ARG A 1 615 ? 136.112 123.378 175.842 1.00 67.65  ?  604 ARG A NE  1 
ATOM   3449 C CZ  . ARG A 1 615 ? 134.825 123.476 176.139 1.00 67.65  ?  604 ARG A CZ  1 
ATOM   3450 N NH1 . ARG A 1 615 ? 133.921 123.473 175.177 1.00 67.65  1  604 ARG A NH1 1 
ATOM   3451 N NH2 . ARG A 1 615 ? 134.445 123.571 177.399 1.00 67.65  ?  604 ARG A NH2 1 
ATOM   3452 N N   . GLU A 1 616 ? 140.291 122.055 170.522 1.00 70.38  ?  605 GLU A N   1 
ATOM   3453 C CA  . GLU A 1 616 ? 141.074 122.712 169.489 1.00 70.38  ?  605 GLU A CA  1 
ATOM   3454 C C   . GLU A 1 616 ? 140.205 123.712 168.743 1.00 70.38  ?  605 GLU A C   1 
ATOM   3455 O O   . GLU A 1 616 ? 139.001 123.519 168.558 1.00 70.38  ?  605 GLU A O   1 
ATOM   3456 C CB  . GLU A 1 616 ? 141.701 121.714 168.513 1.00 70.38  ?  605 GLU A CB  1 
ATOM   3457 C CG  . GLU A 1 616 ? 142.373 120.531 169.168 1.00 70.38  ?  605 GLU A CG  1 
ATOM   3458 C CD  . GLU A 1 616 ? 143.039 119.634 168.164 1.00 70.38  ?  605 GLU A CD  1 
ATOM   3459 O OE1 . GLU A 1 616 ? 142.388 119.289 167.159 1.00 70.38  ?  605 GLU A OE1 1 
ATOM   3460 O OE2 . GLU A 1 616 ? 144.217 119.283 168.377 1.00 70.38  -1 605 GLU A OE2 1 
ATOM   3461 N N   . GLU A 1 617 ? 140.841 124.786 168.309 1.00 61.06  ?  606 GLU A N   1 
ATOM   3462 C CA  . GLU A 1 617 ? 140.143 126.009 167.966 1.00 61.06  ?  606 GLU A CA  1 
ATOM   3463 C C   . GLU A 1 617 ? 139.900 126.110 166.472 1.00 61.06  ?  606 GLU A C   1 
ATOM   3464 O O   . GLU A 1 617 ? 140.635 125.563 165.652 1.00 61.06  ?  606 GLU A O   1 
ATOM   3465 C CB  . GLU A 1 617 ? 140.931 127.215 168.468 1.00 61.06  ?  606 GLU A CB  1 
ATOM   3466 C CG  . GLU A 1 617 ? 141.185 127.142 169.952 1.00 61.06  ?  606 GLU A CG  1 
ATOM   3467 C CD  . GLU A 1 617 ? 142.575 126.678 170.285 1.00 61.06  ?  606 GLU A CD  1 
ATOM   3468 O OE1 . GLU A 1 617 ? 143.445 126.741 169.391 1.00 61.06  ?  606 GLU A OE1 1 
ATOM   3469 O OE2 . GLU A 1 617 ? 142.790 126.246 171.437 1.00 61.06  -1 606 GLU A OE2 1 
ATOM   3470 N N   . GLY A 1 618 ? 138.857 126.865 166.138 1.00 63.72  ?  607 GLY A N   1 
ATOM   3471 C CA  . GLY A 1 618 ? 138.341 126.985 164.806 1.00 63.72  ?  607 GLY A CA  1 
ATOM   3472 C C   . GLY A 1 618 ? 137.055 126.219 164.601 1.00 63.72  ?  607 GLY A C   1 
ATOM   3473 O O   . GLY A 1 618 ? 136.397 126.391 163.573 1.00 63.72  ?  607 GLY A O   1 
ATOM   3474 N N   . SER A 1 619 ? 136.691 125.379 165.556 1.00 68.89  ?  608 SER A N   1 
ATOM   3475 C CA  . SER A 1 619 ? 135.536 124.531 165.305 1.00 68.89  ?  608 SER A CA  1 
ATOM   3476 C C   . SER A 1 619 ? 134.293 125.116 165.968 1.00 68.89  ?  608 SER A C   1 
ATOM   3477 O O   . SER A 1 619 ? 134.251 125.257 167.193 1.00 68.89  ?  608 SER A O   1 
ATOM   3478 C CB  . SER A 1 619 ? 135.782 123.118 165.816 1.00 68.89  ?  608 SER A CB  1 
ATOM   3479 O OG  . SER A 1 619 ? 136.841 122.505 165.107 1.00 68.89  ?  608 SER A OG  1 
ATOM   3480 N N   . PRO A 1 620 ? 133.279 125.429 165.166 1.00 70.93  ?  609 PRO A N   1 
ATOM   3481 C CA  . PRO A 1 620 ? 132.124 126.168 165.682 1.00 70.93  ?  609 PRO A CA  1 
ATOM   3482 C C   . PRO A 1 620 ? 131.234 125.337 166.593 1.00 70.93  ?  609 PRO A C   1 
ATOM   3483 O O   . PRO A 1 620 ? 130.711 124.292 166.205 1.00 70.93  ?  609 PRO A O   1 
ATOM   3484 C CB  . PRO A 1 620 ? 131.379 126.578 164.405 1.00 70.93  ?  609 PRO A CB  1 
ATOM   3485 C CG  . PRO A 1 620 ? 131.829 125.625 163.362 1.00 70.93  ?  609 PRO A CG  1 
ATOM   3486 C CD  . PRO A 1 620 ? 133.228 125.256 163.705 1.00 70.93  ?  609 PRO A CD  1 
ATOM   3487 N N   . LEU A 1 621 ? 131.028 125.847 167.802 1.00 68.48  ?  610 LEU A N   1 
ATOM   3488 C CA  . LEU A 1 621 ? 130.339 125.137 168.867 1.00 68.48  ?  610 LEU A CA  1 
ATOM   3489 C C   . LEU A 1 621 ? 128.987 125.784 169.131 1.00 68.48  ?  610 LEU A C   1 
ATOM   3490 O O   . LEU A 1 621 ? 128.816 126.989 168.952 1.00 68.48  ?  610 LEU A O   1 
ATOM   3491 C CB  . LEU A 1 621 ? 131.200 125.127 170.138 1.00 68.48  ?  610 LEU A CB  1 
ATOM   3492 C CG  . LEU A 1 621 ? 130.753 124.489 171.455 1.00 68.48  ?  610 LEU A CG  1 
ATOM   3493 C CD1 . LEU A 1 621 ? 130.379 123.023 171.276 1.00 68.48  ?  610 LEU A CD1 1 
ATOM   3494 C CD2 . LEU A 1 621 ? 131.888 124.615 172.447 1.00 68.48  ?  610 LEU A CD2 1 
ATOM   3495 N N   . GLU A 1 622 ? 128.019 124.970 169.536 1.00 74.00  ?  611 GLU A N   1 
ATOM   3496 C CA  . GLU A 1 622 ? 126.648 125.417 169.718 1.00 74.00  ?  611 GLU A CA  1 
ATOM   3497 C C   . GLU A 1 622 ? 126.430 125.857 171.160 1.00 74.00  ?  611 GLU A C   1 
ATOM   3498 O O   . GLU A 1 622 ? 126.867 125.188 172.100 1.00 74.00  ?  611 GLU A O   1 
ATOM   3499 C CB  . GLU A 1 622 ? 125.648 124.322 169.296 1.00 74.00  ?  611 GLU A CB  1 
ATOM   3500 C CG  . GLU A 1 622 ? 125.739 122.978 170.012 1.00 74.00  ?  611 GLU A CG  1 
ATOM   3501 C CD  . GLU A 1 622 ? 124.861 122.909 171.249 1.00 74.00  ?  611 GLU A CD  1 
ATOM   3502 O OE1 . GLU A 1 622 ? 123.925 123.730 171.369 1.00 74.00  ?  611 GLU A OE1 1 
ATOM   3503 O OE2 . GLU A 1 622 ? 125.109 122.033 172.100 1.00 74.00  -1 611 GLU A OE2 1 
ATOM   3504 N N   . LEU A 1 623 ? 125.787 127.006 171.322 1.00 69.72  ?  612 LEU A N   1 
ATOM   3505 C CA  . LEU A 1 623 ? 125.734 127.703 172.607 1.00 69.72  ?  612 LEU A CA  1 
ATOM   3506 C C   . LEU A 1 623 ? 124.465 127.385 173.381 1.00 69.72  ?  612 LEU A C   1 
ATOM   3507 O O   . LEU A 1 623 ? 123.827 128.292 173.909 1.00 69.72  ?  612 LEU A O   1 
ATOM   3508 C CB  . LEU A 1 623 ? 125.835 129.207 172.381 1.00 69.72  ?  612 LEU A CB  1 
ATOM   3509 C CG  . LEU A 1 623 ? 127.094 129.919 171.889 1.00 69.72  ?  612 LEU A CG  1 
ATOM   3510 C CD1 . LEU A 1 623 ? 127.253 129.807 170.399 1.00 69.72  ?  612 LEU A CD1 1 
ATOM   3511 C CD2 . LEU A 1 623 ? 127.001 131.356 172.263 1.00 69.72  ?  612 LEU A CD2 1 
ATOM   3512 N N   . GLU A 1 624 ? 124.073 126.139 173.482 1.00 74.84  ?  613 GLU A N   1 
ATOM   3513 C CA  . GLU A 1 624 ? 122.949 125.833 174.362 1.00 74.84  ?  613 GLU A CA  1 
ATOM   3514 C C   . GLU A 1 624 ? 123.257 124.701 175.323 1.00 74.84  ?  613 GLU A C   1 
ATOM   3515 O O   . GLU A 1 624 ? 122.864 124.768 176.486 1.00 74.84  ?  613 GLU A O   1 
ATOM   3516 C CB  . GLU A 1 624 ? 121.687 125.513 173.551 1.00 74.84  ?  613 GLU A CB  1 
ATOM   3517 C CG  . GLU A 1 624 ? 121.041 126.743 172.917 1.00 74.84  ?  613 GLU A CG  1 
ATOM   3518 C CD  . GLU A 1 624 ? 121.432 126.930 171.468 1.00 74.84  ?  613 GLU A CD  1 
ATOM   3519 O OE1 . GLU A 1 624 ? 122.436 126.326 171.040 1.00 74.84  ?  613 GLU A OE1 1 
ATOM   3520 O OE2 . GLU A 1 624 ? 120.735 127.684 170.758 1.00 74.84  -1 613 GLU A OE2 1 
ATOM   3521 N N   . ARG A 1 625 ? 123.938 123.662 174.863 1.00 78.93  ?  614 ARG A N   1 
ATOM   3522 C CA  . ARG A 1 625 ? 124.646 122.738 175.740 1.00 78.93  ?  614 ARG A CA  1 
ATOM   3523 C C   . ARG A 1 625 ? 126.129 123.082 175.789 1.00 78.93  ?  614 ARG A C   1 
ATOM   3524 O O   . ARG A 1 625 ? 126.985 122.313 175.354 1.00 78.93  ?  614 ARG A O   1 
ATOM   3525 C CB  . ARG A 1 625 ? 124.423 121.297 175.292 1.00 78.93  ?  614 ARG A CB  1 
ATOM   3526 C CG  . ARG A 1 625 ? 123.209 120.616 175.923 1.00 78.93  ?  614 ARG A CG  1 
ATOM   3527 C CD  . ARG A 1 625 ? 121.907 121.003 175.249 1.00 78.93  ?  614 ARG A CD  1 
ATOM   3528 N NE  . ARG A 1 625 ? 121.812 120.505 173.883 1.00 78.93  ?  614 ARG A NE  1 
ATOM   3529 C CZ  . ARG A 1 625 ? 120.942 120.963 172.988 1.00 78.93  ?  614 ARG A CZ  1 
ATOM   3530 N NH1 . ARG A 1 625 ? 120.112 121.942 173.316 1.00 78.93  1  614 ARG A NH1 1 
ATOM   3531 N NH2 . ARG A 1 625 ? 120.913 120.455 171.763 1.00 78.93  ?  614 ARG A NH2 1 
ATOM   3532 N N   . LEU A 1 626 ? 126.431 124.274 176.305 1.00 71.85  ?  615 LEU A N   1 
ATOM   3533 C CA  . LEU A 1 626 ? 127.798 124.735 176.519 1.00 71.85  ?  615 LEU A CA  1 
ATOM   3534 C C   . LEU A 1 626 ? 128.204 124.381 177.944 1.00 71.85  ?  615 LEU A C   1 
ATOM   3535 O O   . LEU A 1 626 ? 127.561 124.825 178.898 1.00 71.85  ?  615 LEU A O   1 
ATOM   3536 C CB  . LEU A 1 626 ? 127.905 126.240 176.282 1.00 71.85  ?  615 LEU A CB  1 
ATOM   3537 C CG  . LEU A 1 626 ? 129.288 126.900 176.271 1.00 71.85  ?  615 LEU A CG  1 
ATOM   3538 C CD1 . LEU A 1 626 ? 130.001 126.662 174.966 1.00 71.85  ?  615 LEU A CD1 1 
ATOM   3539 C CD2 . LEU A 1 626 ? 129.147 128.381 176.519 1.00 71.85  ?  615 LEU A CD2 1 
ATOM   3540 N N   . LYS A 1 627 ? 129.255 123.578 178.081 1.00 67.96  ?  616 LYS A N   1 
ATOM   3541 C CA  . LYS A 1 627 ? 129.692 123.044 179.362 1.00 67.96  ?  616 LYS A CA  1 
ATOM   3542 C C   . LYS A 1 627 ? 131.105 123.516 179.672 1.00 67.96  ?  616 LYS A C   1 
ATOM   3543 O O   . LYS A 1 627 ? 131.956 123.589 178.782 1.00 67.96  ?  616 LYS A O   1 
ATOM   3544 C CB  . LYS A 1 627 ? 129.635 121.507 179.362 1.00 67.96  ?  616 LYS A CB  1 
ATOM   3545 C CG  . LYS A 1 627 ? 129.997 120.854 180.693 1.00 67.96  ?  616 LYS A CG  1 
ATOM   3546 C CD  . LYS A 1 627 ? 129.838 119.359 180.657 1.00 67.96  ?  616 LYS A CD  1 
ATOM   3547 C CE  . LYS A 1 627 ? 128.382 118.989 180.737 1.00 67.96  ?  616 LYS A CE  1 
ATOM   3548 N NZ  . LYS A 1 627 ? 127.834 119.368 182.061 1.00 67.96  1  616 LYS A NZ  1 
ATOM   3549 N N   . LEU A 1 628 ? 131.357 123.838 180.942 1.00 59.56  ?  617 LEU A N   1 
ATOM   3550 C CA  . LEU A 1 628 ? 132.661 124.330 181.365 1.00 59.56  ?  617 LEU A CA  1 
ATOM   3551 C C   . LEU A 1 628 ? 133.241 123.495 182.494 1.00 59.56  ?  617 LEU A C   1 
ATOM   3552 O O   . LEU A 1 628 ? 132.605 123.320 183.537 1.00 59.56  ?  617 LEU A O   1 
ATOM   3553 C CB  . LEU A 1 628 ? 132.578 125.774 181.829 1.00 59.56  ?  617 LEU A CB  1 
ATOM   3554 C CG  . LEU A 1 628 ? 132.184 126.765 180.761 1.00 59.56  ?  617 LEU A CG  1 
ATOM   3555 C CD1 . LEU A 1 628 ? 132.247 128.139 181.360 1.00 59.56  ?  617 LEU A CD1 1 
ATOM   3556 C CD2 . LEU A 1 628 ? 133.116 126.632 179.600 1.00 59.56  ?  617 LEU A CD2 1 
ATOM   3557 N N   . GLU A 1 629 ? 134.465 123.022 182.293 1.00 58.46  ?  618 GLU A N   1 
ATOM   3558 C CA  . GLU A 1 629 ? 135.246 122.447 183.364 1.00 58.46  ?  618 GLU A CA  1 
ATOM   3559 C C   . GLU A 1 629 ? 135.762 123.574 184.269 1.00 58.46  ?  618 GLU A C   1 
ATOM   3560 O O   . GLU A 1 629 ? 135.742 124.736 183.868 1.00 58.46  ?  618 GLU A O   1 
ATOM   3561 C CB  . GLU A 1 629 ? 136.356 121.592 182.750 1.00 58.46  ?  618 GLU A CB  1 
ATOM   3562 C CG  . GLU A 1 629 ? 137.258 122.319 181.806 1.00 58.46  ?  618 GLU A CG  1 
ATOM   3563 C CD  . GLU A 1 629 ? 138.250 121.402 181.129 1.00 58.46  ?  618 GLU A CD  1 
ATOM   3564 O OE1 . GLU A 1 629 ? 138.148 120.180 181.324 1.00 58.46  ?  618 GLU A OE1 1 
ATOM   3565 O OE2 . GLU A 1 629 ? 139.145 121.901 180.419 1.00 58.46  -1 618 GLU A OE2 1 
ATOM   3566 N N   . PRO A 1 630 ? 136.145 123.272 185.518 1.00 57.83  ?  619 PRO A N   1 
ATOM   3567 C CA  . PRO A 1 630 ? 136.495 124.342 186.471 1.00 57.83  ?  619 PRO A CA  1 
ATOM   3568 C C   . PRO A 1 630 ? 137.693 125.190 186.061 1.00 57.83  ?  619 PRO A C   1 
ATOM   3569 O O   . PRO A 1 630 ? 138.656 124.693 185.471 1.00 57.83  ?  619 PRO A O   1 
ATOM   3570 C CB  . PRO A 1 630 ? 136.785 123.573 187.760 1.00 57.83  ?  619 PRO A CB  1 
ATOM   3571 C CG  . PRO A 1 630 ? 135.920 122.415 187.674 1.00 57.83  ?  619 PRO A CG  1 
ATOM   3572 C CD  . PRO A 1 630 ? 135.882 122.011 186.239 1.00 57.83  ?  619 PRO A CD  1 
ATOM   3573 N N   . HIS A 1 631 ? 137.594 126.489 186.382 1.00 50.90  ?  620 HIS A N   1 
ATOM   3574 C CA  . HIS A 1 631 ? 138.604 127.516 186.118 1.00 50.90  ?  620 HIS A CA  1 
ATOM   3575 C C   . HIS A 1 631 ? 138.917 127.645 184.630 1.00 50.90  ?  620 HIS A C   1 
ATOM   3576 O O   . HIS A 1 631 ? 140.073 127.742 184.225 1.00 50.90  ?  620 HIS A O   1 
ATOM   3577 C CB  . HIS A 1 631 ? 139.872 127.265 186.926 1.00 50.90  ?  620 HIS A CB  1 
ATOM   3578 C CG  . HIS A 1 631 ? 139.644 127.211 188.399 1.00 50.90  ?  620 HIS A CG  1 
ATOM   3579 N ND1 . HIS A 1 631 ? 140.290 126.313 189.219 1.00 50.90  ?  620 HIS A ND1 1 
ATOM   3580 C CD2 . HIS A 1 631 ? 138.853 127.955 189.206 1.00 50.90  ?  620 HIS A CD2 1 
ATOM   3581 C CE1 . HIS A 1 631 ? 139.905 126.503 190.466 1.00 50.90  ?  620 HIS A CE1 1 
ATOM   3582 N NE2 . HIS A 1 631 ? 139.033 127.494 190.487 1.00 50.90  ?  620 HIS A NE2 1 
ATOM   3583 N N   . GLU A 1 632 ? 137.881 127.682 183.810 1.00 49.19  ?  621 GLU A N   1 
ATOM   3584 C CA  . GLU A 1 632 ? 138.047 127.713 182.369 1.00 49.19  ?  621 GLU A CA  1 
ATOM   3585 C C   . GLU A 1 632 ? 137.429 128.982 181.795 1.00 49.19  ?  621 GLU A C   1 
ATOM   3586 O O   . GLU A 1 632 ? 136.385 129.444 182.255 1.00 49.19  ?  621 GLU A O   1 
ATOM   3587 C CB  . GLU A 1 632 ? 137.398 126.488 181.727 1.00 49.19  ?  621 GLU A CB  1 
ATOM   3588 C CG  . GLU A 1 632 ? 137.817 126.218 180.306 1.00 49.19  ?  621 GLU A CG  1 
ATOM   3589 C CD  . GLU A 1 632 ? 136.915 125.222 179.632 1.00 49.19  ?  621 GLU A CD  1 
ATOM   3590 O OE1 . GLU A 1 632 ? 135.867 124.891 180.220 1.00 49.19  ?  621 GLU A OE1 1 
ATOM   3591 O OE2 . GLU A 1 632 ? 137.248 124.762 178.523 1.00 49.19  -1 621 GLU A OE2 1 
ATOM   3592 N N   . GLY A 1 633 ? 138.079 129.537 180.790 1.00 36.35  ?  622 GLY A N   1 
ATOM   3593 C CA  . GLY A 1 633 ? 137.537 130.676 180.069 1.00 36.35  ?  622 GLY A CA  1 
ATOM   3594 C C   . GLY A 1 633 ? 137.598 130.440 178.579 1.00 36.35  ?  622 GLY A C   1 
ATOM   3595 O O   . GLY A 1 633 ? 138.481 129.751 178.093 1.00 36.35  ?  622 GLY A O   1 
ATOM   3596 N N   . LEU A 1 634 ? 136.634 131.005 177.860 1.00 33.33  ?  623 LEU A N   1 
ATOM   3597 C CA  . LEU A 1 634 ? 136.516 130.792 176.426 1.00 33.33  ?  623 LEU A CA  1 
ATOM   3598 C C   . LEU A 1 634 ? 136.434 132.115 175.676 1.00 33.33  ?  623 LEU A C   1 
ATOM   3599 O O   . LEU A 1 634 ? 135.941 133.113 176.194 1.00 33.33  ?  623 LEU A O   1 
ATOM   3600 C CB  . LEU A 1 634 ? 135.279 129.961 176.081 1.00 33.33  ?  623 LEU A CB  1 
ATOM   3601 C CG  . LEU A 1 634 ? 134.764 128.838 176.975 1.00 33.33  ?  623 LEU A CG  1 
ATOM   3602 C CD1 . LEU A 1 634 ? 133.484 128.347 176.389 1.00 33.33  ?  623 LEU A CD1 1 
ATOM   3603 C CD2 . LEU A 1 634 ? 135.739 127.711 177.097 1.00 33.33  ?  623 LEU A CD2 1 
ATOM   3604 N N   . LEU A 1 635 ? 136.871 132.085 174.422 1.00 31.08  ?  624 LEU A N   1 
ATOM   3605 C CA  . LEU A 1 635 ? 136.927 133.247 173.540 1.00 31.08  ?  624 LEU A CA  1 
ATOM   3606 C C   . LEU A 1 635 ? 136.197 132.940 172.222 1.00 31.08  ?  624 LEU A C   1 
ATOM   3607 O O   . LEU A 1 635 ? 136.795 132.871 171.151 1.00 31.08  ?  624 LEU A O   1 
ATOM   3608 C CB  . LEU A 1 635 ? 138.360 133.708 173.299 1.00 31.08  ?  624 LEU A CB  1 
ATOM   3609 C CG  . LEU A 1 635 ? 138.526 135.116 172.718 1.00 31.08  ?  624 LEU A CG  1 
ATOM   3610 C CD1 . LEU A 1 635 ? 137.579 136.096 173.345 1.00 31.08  ?  624 LEU A CD1 1 
ATOM   3611 C CD2 . LEU A 1 635 ? 139.939 135.597 172.834 1.00 31.08  ?  624 LEU A CD2 1 
ATOM   3612 N N   . LEU A 1 636 ? 134.907 132.634 172.316 1.00 36.88  ?  625 LEU A N   1 
ATOM   3613 C CA  . LEU A 1 636 ? 134.062 132.471 171.135 1.00 36.88  ?  625 LEU A CA  1 
ATOM   3614 C C   . LEU A 1 636 ? 134.007 133.750 170.292 1.00 36.88  ?  625 LEU A C   1 
ATOM   3615 O O   . LEU A 1 636 ? 134.355 134.838 170.741 1.00 36.88  ?  625 LEU A O   1 
ATOM   3616 C CB  . LEU A 1 636 ? 132.643 132.075 171.531 1.00 36.88  ?  625 LEU A CB  1 
ATOM   3617 C CG  . LEU A 1 636 ? 132.281 130.635 171.910 1.00 36.88  ?  625 LEU A CG  1 
ATOM   3618 C CD1 . LEU A 1 636 ? 132.978 130.135 173.144 1.00 36.88  ?  625 LEU A CD1 1 
ATOM   3619 C CD2 . LEU A 1 636 ? 130.790 130.490 172.076 1.00 36.88  ?  625 LEU A CD2 1 
ATOM   3620 N N   . ARG A 1 637 ? 133.554 133.610 169.047 1.00 39.65  ?  626 ARG A N   1 
ATOM   3621 C CA  . ARG A 1 637 ? 133.574 134.718 168.100 1.00 39.65  ?  626 ARG A CA  1 
ATOM   3622 C C   . ARG A 1 637 ? 132.521 134.493 167.028 1.00 39.65  ?  626 ARG A C   1 
ATOM   3623 O O   . ARG A 1 637 ? 132.235 133.356 166.653 1.00 39.65  ?  626 ARG A O   1 
ATOM   3624 C CB  . ARG A 1 637 ? 134.955 134.857 167.476 1.00 39.65  ?  626 ARG A CB  1 
ATOM   3625 C CG  . ARG A 1 637 ? 135.264 136.212 166.891 1.00 39.65  ?  626 ARG A CG  1 
ATOM   3626 C CD  . ARG A 1 637 ? 135.219 136.208 165.384 1.00 39.65  ?  626 ARG A CD  1 
ATOM   3627 N NE  . ARG A 1 637 ? 136.001 135.094 164.858 1.00 39.65  ?  626 ARG A NE  1 
ATOM   3628 C CZ  . ARG A 1 637 ? 137.326 135.066 164.752 1.00 39.65  ?  626 ARG A CZ  1 
ATOM   3629 N NH1 . ARG A 1 637 ? 138.065 136.099 165.127 1.00 39.65  1  626 ARG A NH1 1 
ATOM   3630 N NH2 . ARG A 1 637 ? 137.918 133.984 164.269 1.00 39.65  ?  626 ARG A NH2 1 
ATOM   3631 N N   . PHE A 1 638 ? 131.945 135.592 166.522 1.00 37.76  ?  627 PHE A N   1 
ATOM   3632 C CA  . PHE A 1 638 ? 130.888 135.472 165.525 1.00 37.76  ?  627 PHE A CA  1 
ATOM   3633 C C   . PHE A 1 638 ? 130.766 136.742 164.702 1.00 37.76  ?  627 PHE A C   1 
ATOM   3634 O O   . PHE A 1 638 ? 131.046 137.823 165.226 1.00 37.76  ?  627 PHE A O   1 
ATOM   3635 C CB  . PHE A 1 638 ? 129.543 135.117 166.177 1.00 37.76  ?  627 PHE A CB  1 
ATOM   3636 C CG  . PHE A 1 638 ? 129.042 136.104 167.180 1.00 37.76  ?  627 PHE A CG  1 
ATOM   3637 C CD1 . PHE A 1 638 ? 129.417 136.017 168.509 1.00 37.76  ?  627 PHE A CD1 1 
ATOM   3638 C CD2 . PHE A 1 638 ? 128.123 137.070 166.812 1.00 37.76  ?  627 PHE A CD2 1 
ATOM   3639 C CE1 . PHE A 1 638 ? 128.930 136.903 169.433 1.00 37.76  ?  627 PHE A CE1 1 
ATOM   3640 C CE2 . PHE A 1 638 ? 127.630 137.956 167.733 1.00 37.76  ?  627 PHE A CE2 1 
ATOM   3641 C CZ  . PHE A 1 638 ? 128.033 137.867 169.045 1.00 37.76  ?  627 PHE A CZ  1 
ATOM   3642 N N   . PRO A 1 639 ? 130.383 136.662 163.429 1.00 42.84  ?  628 PRO A N   1 
ATOM   3643 C CA  . PRO A 1 639 ? 130.369 137.856 162.580 1.00 42.84  ?  628 PRO A CA  1 
ATOM   3644 C C   . PRO A 1 639 ? 129.036 138.593 162.614 1.00 42.84  ?  628 PRO A C   1 
ATOM   3645 O O   . PRO A 1 639 ? 128.040 138.131 163.169 1.00 42.84  ?  628 PRO A O   1 
ATOM   3646 C CB  . PRO A 1 639 ? 130.631 137.284 161.191 1.00 42.84  ?  628 PRO A CB  1 
ATOM   3647 C CG  . PRO A 1 639 ? 129.981 135.968 161.251 1.00 42.84  ?  628 PRO A CG  1 
ATOM   3648 C CD  . PRO A 1 639 ? 130.204 135.440 162.626 1.00 42.84  ?  628 PRO A CD  1 
ATOM   3649 N N   . TYR A 1 640 ? 129.040 139.759 161.972 1.00 40.41  ?  629 TYR A N   1 
ATOM   3650 C CA  . TYR A 1 640 ? 127.874 140.627 161.953 1.00 40.41  ?  629 TYR A CA  1 
ATOM   3651 C C   . TYR A 1 640 ? 126.792 140.043 161.060 1.00 40.41  ?  629 TYR A C   1 
ATOM   3652 O O   . TYR A 1 640 ? 127.020 139.780 159.876 1.00 40.41  ?  629 TYR A O   1 
ATOM   3653 C CB  . TYR A 1 640 ? 128.267 142.017 161.462 1.00 40.41  ?  629 TYR A CB  1 
ATOM   3654 C CG  . TYR A 1 640 ? 127.103 142.918 161.130 1.00 40.41  ?  629 TYR A CG  1 
ATOM   3655 C CD1 . TYR A 1 640 ? 126.351 143.497 162.130 1.00 40.41  ?  629 TYR A CD1 1 
ATOM   3656 C CD2 . TYR A 1 640 ? 126.764 143.196 159.810 1.00 40.41  ?  629 TYR A CD2 1 
ATOM   3657 C CE1 . TYR A 1 640 ? 125.291 144.323 161.834 1.00 40.41  ?  629 TYR A CE1 1 
ATOM   3658 C CE2 . TYR A 1 640 ? 125.699 144.010 159.506 1.00 40.41  ?  629 TYR A CE2 1 
ATOM   3659 C CZ  . TYR A 1 640 ? 124.970 144.572 160.523 1.00 40.41  ?  629 TYR A CZ  1 
ATOM   3660 O OH  . TYR A 1 640 ? 123.915 145.396 160.230 1.00 40.41  ?  629 TYR A OH  1 
ATOM   3661 N N   . ALA A 1 641 ? 125.610 139.851 161.626 1.00 48.14  ?  630 ALA A N   1 
ATOM   3662 C CA  . ALA A 1 641 ? 124.478 139.315 160.894 1.00 48.14  ?  630 ALA A CA  1 
ATOM   3663 C C   . ALA A 1 641 ? 123.216 139.871 161.542 1.00 48.14  ?  630 ALA A C   1 
ATOM   3664 O O   . ALA A 1 641 ? 123.262 140.886 162.244 1.00 48.14  ?  630 ALA A O   1 
ATOM   3665 C CB  . ALA A 1 641 ? 124.527 137.778 160.876 1.00 48.14  ?  630 ALA A CB  1 
ATOM   3666 N N   . ALA A 1 642 ? 122.087 139.216 161.301 1.00 62.60  ?  631 ALA A N   1 
ATOM   3667 C CA  . ALA A 1 642 ? 120.826 139.626 161.907 1.00 62.60  ?  631 ALA A CA  1 
ATOM   3668 C C   . ALA A 1 642 ? 120.133 138.449 162.582 1.00 62.60  ?  631 ALA A C   1 
ATOM   3669 O O   . ALA A 1 642 ? 119.350 137.737 161.955 1.00 62.60  ?  631 ALA A O   1 
ATOM   3670 C CB  . ALA A 1 642 ? 119.913 140.252 160.862 1.00 62.60  ?  631 ALA A CB  1 
ATOM   3671 N N   . GLN B 2 48  ? 135.294 144.893 101.079 1.00 70.08  ?  30  GLN B N   1 
ATOM   3672 C CA  . GLN B 2 48  ? 135.586 143.541 101.537 1.00 70.08  ?  30  GLN B CA  1 
ATOM   3673 C C   . GLN B 2 48  ? 135.363 143.424 103.036 1.00 70.08  ?  30  GLN B C   1 
ATOM   3674 O O   . GLN B 2 48  ? 135.915 144.199 103.813 1.00 70.08  ?  30  GLN B O   1 
ATOM   3675 C CB  . GLN B 2 48  ? 137.021 143.153 101.187 1.00 70.08  ?  30  GLN B CB  1 
ATOM   3676 C CG  . GLN B 2 48  ? 137.420 141.770 101.669 1.00 70.08  ?  30  GLN B CG  1 
ATOM   3677 C CD  . GLN B 2 48  ? 138.921 141.565 101.674 1.00 70.08  ?  30  GLN B CD  1 
ATOM   3678 O OE1 . GLN B 2 48  ? 139.684 142.474 101.352 1.00 70.08  ?  30  GLN B OE1 1 
ATOM   3679 N NE2 . GLN B 2 48  ? 139.353 140.367 102.046 1.00 70.08  ?  30  GLN B NE2 1 
ATOM   3680 N N   . VAL B 2 49  ? 134.556 142.449 103.443 1.00 63.79  ?  31  VAL B N   1 
ATOM   3681 C CA  . VAL B 2 49  ? 134.230 142.255 104.854 1.00 63.79  ?  31  VAL B CA  1 
ATOM   3682 C C   . VAL B 2 49  ? 135.376 141.449 105.459 1.00 63.79  ?  31  VAL B C   1 
ATOM   3683 O O   . VAL B 2 49  ? 135.389 140.220 105.439 1.00 63.79  ?  31  VAL B O   1 
ATOM   3684 C CB  . VAL B 2 49  ? 132.873 141.586 105.043 1.00 63.79  ?  31  VAL B CB  1 
ATOM   3685 C CG1 . VAL B 2 49  ? 132.543 141.460 106.520 1.00 63.79  ?  31  VAL B CG1 1 
ATOM   3686 C CG2 . VAL B 2 49  ? 131.802 142.387 104.340 1.00 63.79  ?  31  VAL B CG2 1 
ATOM   3687 N N   . LYS B 2 50  ? 136.367 142.163 105.982 1.00 61.98  ?  32  LYS B N   1 
ATOM   3688 C CA  . LYS B 2 50  ? 137.416 141.559 106.790 1.00 61.98  ?  32  LYS B CA  1 
ATOM   3689 C C   . LYS B 2 50  ? 137.540 142.370 108.071 1.00 61.98  ?  32  LYS B C   1 
ATOM   3690 O O   . LYS B 2 50  ? 136.694 143.225 108.340 1.00 61.98  ?  32  LYS B O   1 
ATOM   3691 C CB  . LYS B 2 50  ? 138.736 141.480 106.021 1.00 61.98  ?  32  LYS B CB  1 
ATOM   3692 C CG  . LYS B 2 50  ? 139.375 142.809 105.682 1.00 61.98  ?  32  LYS B CG  1 
ATOM   3693 C CD  . LYS B 2 50  ? 140.671 142.596 104.917 1.00 61.98  ?  32  LYS B CD  1 
ATOM   3694 C CE  . LYS B 2 50  ? 141.333 143.915 104.564 1.00 61.98  ?  32  LYS B CE  1 
ATOM   3695 N NZ  . LYS B 2 50  ? 141.814 144.626 105.779 1.00 61.98  1  32  LYS B NZ  1 
ATOM   3696 N N   . LEU B 2 51  ? 138.566 142.119 108.876 1.00 58.18  ?  33  LEU B N   1 
ATOM   3697 C CA  . LEU B 2 51  ? 138.568 142.606 110.245 1.00 58.18  ?  33  LEU B CA  1 
ATOM   3698 C C   . LEU B 2 51  ? 139.343 143.917 110.409 1.00 58.18  ?  33  LEU B C   1 
ATOM   3699 O O   . LEU B 2 51  ? 139.396 144.448 111.523 1.00 58.18  ?  33  LEU B O   1 
ATOM   3700 C CB  . LEU B 2 51  ? 139.095 141.501 111.170 1.00 58.18  ?  33  LEU B CB  1 
ATOM   3701 C CG  . LEU B 2 51  ? 138.780 141.500 112.668 1.00 58.18  ?  33  LEU B CG  1 
ATOM   3702 C CD1 . LEU B 2 51  ? 137.281 141.493 112.879 1.00 58.18  ?  33  LEU B CD1 1 
ATOM   3703 C CD2 . LEU B 2 51  ? 139.391 140.287 113.324 1.00 58.18  ?  33  LEU B CD2 1 
ATOM   3704 N N   . LYS B 2 52  ? 139.905 144.466 109.320 1.00 60.36  ?  34  LYS B N   1 
ATOM   3705 C CA  . LYS B 2 52  ? 140.298 145.878 109.226 1.00 60.36  ?  34  LYS B CA  1 
ATOM   3706 C C   . LYS B 2 52  ? 141.345 146.342 110.233 1.00 60.36  ?  34  LYS B C   1 
ATOM   3707 O O   . LYS B 2 52  ? 140.984 146.934 111.253 1.00 60.36  ?  34  LYS B O   1 
ATOM   3708 C CB  . LYS B 2 52  ? 139.071 146.788 109.331 1.00 60.36  ?  34  LYS B CB  1 
ATOM   3709 C CG  . LYS B 2 52  ? 138.134 146.710 108.144 1.00 60.36  ?  34  LYS B CG  1 
ATOM   3710 C CD  . LYS B 2 52  ? 138.869 146.857 106.829 1.00 60.36  ?  34  LYS B CD  1 
ATOM   3711 C CE  . LYS B 2 52  ? 138.015 146.352 105.683 1.00 60.36  ?  34  LYS B CE  1 
ATOM   3712 N NZ  . LYS B 2 52  ? 138.795 146.191 104.428 1.00 60.36  1  34  LYS B NZ  1 
ATOM   3713 N N   . LYS B 2 53  ? 142.621 146.027 109.994 1.00 58.44  ?  35  LYS B N   1 
ATOM   3714 C CA  . LYS B 2 53  ? 143.690 146.248 110.965 1.00 58.44  ?  35  LYS B CA  1 
ATOM   3715 C C   . LYS B 2 53  ? 143.897 147.715 111.323 1.00 58.44  ?  35  LYS B C   1 
ATOM   3716 O O   . LYS B 2 53  ? 144.529 148.462 110.571 1.00 58.44  ?  35  LYS B O   1 
ATOM   3717 C CB  . LYS B 2 53  ? 145.009 145.710 110.407 1.00 58.44  ?  35  LYS B CB  1 
ATOM   3718 C CG  . LYS B 2 53  ? 144.869 144.494 109.520 1.00 58.44  ?  35  LYS B CG  1 
ATOM   3719 C CD  . LYS B 2 53  ? 146.219 143.868 109.246 1.00 58.44  ?  35  LYS B CD  1 
ATOM   3720 C CE  . LYS B 2 53  ? 147.096 144.800 108.443 1.00 58.44  ?  35  LYS B CE  1 
ATOM   3721 N NZ  . LYS B 2 53  ? 148.409 144.176 108.133 1.00 58.44  1  35  LYS B NZ  1 
ATOM   3722 N N   . GLU B 2 54  ? 143.379 148.131 112.490 1.00 60.32  ?  36  GLU B N   1 
ATOM   3723 C CA  . GLU B 2 54  ? 143.508 149.503 112.987 1.00 60.32  ?  36  GLU B CA  1 
ATOM   3724 C C   . GLU B 2 54  ? 143.949 149.469 114.451 1.00 60.32  ?  36  GLU B C   1 
ATOM   3725 O O   . GLU B 2 54  ? 143.129 149.707 115.337 1.00 60.32  ?  36  GLU B O   1 
ATOM   3726 C CB  . GLU B 2 54  ? 142.172 150.253 112.844 1.00 60.32  ?  36  GLU B CB  1 
ATOM   3727 C CG  . GLU B 2 54  ? 141.560 150.283 111.452 1.00 60.32  ?  36  GLU B CG  1 
ATOM   3728 C CD  . GLU B 2 54  ? 141.957 151.512 110.665 1.00 60.32  ?  36  GLU B CD  1 
ATOM   3729 O OE1 . GLU B 2 54  ? 142.406 151.359 109.510 1.00 60.32  ?  36  GLU B OE1 1 
ATOM   3730 O OE2 . GLU B 2 54  ? 141.816 152.632 111.199 1.00 60.32  -1 36  GLU B OE2 1 
ATOM   3731 N N   . ILE B 2 55  ? 145.245 149.263 114.693 1.00 52.45  ?  37  ILE B N   1 
ATOM   3732 C CA  . ILE B 2 55  ? 145.838 149.335 116.029 1.00 52.45  ?  37  ILE B CA  1 
ATOM   3733 C C   . ILE B 2 55  ? 147.256 149.860 115.853 1.00 52.45  ?  37  ILE B C   1 
ATOM   3734 O O   . ILE B 2 55  ? 148.078 149.240 115.171 1.00 52.45  ?  37  ILE B O   1 
ATOM   3735 C CB  . ILE B 2 55  ? 145.833 147.976 116.766 1.00 52.45  ?  37  ILE B CB  1 
ATOM   3736 C CG1 . ILE B 2 55  ? 144.481 147.685 117.412 1.00 52.45  ?  37  ILE B CG1 1 
ATOM   3737 C CG2 . ILE B 2 55  ? 146.860 147.950 117.887 1.00 52.45  ?  37  ILE B CG2 1 
ATOM   3738 C CD1 . ILE B 2 55  ? 144.373 146.313 118.013 1.00 52.45  ?  37  ILE B CD1 1 
ATOM   3739 N N   . SER B 2 56  ? 147.553 151.006 116.449 1.00 51.39  ?  38  SER B N   1 
ATOM   3740 C CA  . SER B 2 56  ? 148.853 151.632 116.279 1.00 51.39  ?  38  SER B CA  1 
ATOM   3741 C C   . SER B 2 56  ? 149.810 151.157 117.369 1.00 51.39  ?  38  SER B C   1 
ATOM   3742 O O   . SER B 2 56  ? 149.518 150.230 118.126 1.00 51.39  ?  38  SER B O   1 
ATOM   3743 C CB  . SER B 2 56  ? 148.705 153.150 116.272 1.00 51.39  ?  38  SER B CB  1 
ATOM   3744 O OG  . SER B 2 56  ? 147.832 153.578 117.300 1.00 51.39  ?  38  SER B OG  1 
ATOM   3745 N N   . LEU B 2 57  ? 150.979 151.795 117.449 1.00 49.08  ?  39  LEU B N   1 
ATOM   3746 C CA  . LEU B 2 57  ? 151.948 151.458 118.484 1.00 49.08  ?  39  LEU B CA  1 
ATOM   3747 C C   . LEU B 2 57  ? 151.472 151.921 119.855 1.00 49.08  ?  39  LEU B C   1 
ATOM   3748 O O   . LEU B 2 57  ? 151.623 151.200 120.851 1.00 49.08  ?  39  LEU B O   1 
ATOM   3749 C CB  . LEU B 2 57  ? 153.298 152.081 118.138 1.00 49.08  ?  39  LEU B CB  1 
ATOM   3750 C CG  . LEU B 2 57  ? 154.396 152.085 119.196 1.00 49.08  ?  39  LEU B CG  1 
ATOM   3751 C CD1 . LEU B 2 57  ? 154.897 150.682 119.445 1.00 49.08  ?  39  LEU B CD1 1 
ATOM   3752 C CD2 . LEU B 2 57  ? 155.529 152.985 118.756 1.00 49.08  ?  39  LEU B CD2 1 
ATOM   3753 N N   . LEU B 2 58  ? 150.874 153.112 119.915 1.00 49.72  ?  40  LEU B N   1 
ATOM   3754 C CA  . LEU B 2 58  ? 150.390 153.660 121.176 1.00 49.72  ?  40  LEU B CA  1 
ATOM   3755 C C   . LEU B 2 58  ? 149.203 152.866 121.706 1.00 49.72  ?  40  LEU B C   1 
ATOM   3756 O O   . LEU B 2 58  ? 149.065 152.689 122.922 1.00 49.72  ?  40  LEU B O   1 
ATOM   3757 C CB  . LEU B 2 58  ? 150.037 155.136 120.983 1.00 49.72  ?  40  LEU B CB  1 
ATOM   3758 C CG  . LEU B 2 58  ? 149.689 156.042 122.163 1.00 49.72  ?  40  LEU B CG  1 
ATOM   3759 C CD1 . LEU B 2 58  ? 150.210 157.424 121.877 1.00 49.72  ?  40  LEU B CD1 1 
ATOM   3760 C CD2 . LEU B 2 58  ? 148.190 156.117 122.379 1.00 49.72  ?  40  LEU B CD2 1 
ATOM   3761 N N   . ASN B 2 59  ? 148.353 152.359 120.808 1.00 49.67  ?  41  ASN B N   1 
ATOM   3762 C CA  . ASN B 2 59  ? 147.231 151.527 121.228 1.00 49.67  ?  41  ASN B CA  1 
ATOM   3763 C C   . ASN B 2 59  ? 147.707 150.203 121.808 1.00 49.67  ?  41  ASN B C   1 
ATOM   3764 O O   . ASN B 2 59  ? 147.145 149.716 122.794 1.00 49.67  ?  41  ASN B O   1 
ATOM   3765 C CB  . ASN B 2 59  ? 146.290 151.279 120.053 1.00 49.67  ?  41  ASN B CB  1 
ATOM   3766 C CG  . ASN B 2 59  ? 145.665 152.546 119.536 1.00 49.67  ?  41  ASN B CG  1 
ATOM   3767 O OD1 . ASN B 2 59  ? 145.597 153.550 120.241 1.00 49.67  ?  41  ASN B OD1 1 
ATOM   3768 N ND2 . ASN B 2 59  ? 145.204 152.512 118.296 1.00 49.67  ?  41  ASN B ND2 1 
ATOM   3769 N N   . GLY B 2 60  ? 148.764 149.626 121.235 1.00 47.73  ?  42  GLY B N   1 
ATOM   3770 C CA  . GLY B 2 60  ? 149.306 148.394 121.775 1.00 47.73  ?  42  GLY B CA  1 
ATOM   3771 C C   . GLY B 2 60  ? 150.004 148.580 123.104 1.00 47.73  ?  42  GLY B C   1 
ATOM   3772 O O   . GLY B 2 60  ? 149.870 147.735 124.001 1.00 47.73  ?  42  GLY B O   1 
ATOM   3773 N N   . VAL B 2 61  ? 150.742 149.686 123.252 1.00 45.70  ?  43  VAL B N   1 
ATOM   3774 C CA  . VAL B 2 61  ? 151.369 150.010 124.530 1.00 45.70  ?  43  VAL B CA  1 
ATOM   3775 C C   . VAL B 2 61  ? 150.310 150.228 125.603 1.00 45.70  ?  43  VAL B C   1 
ATOM   3776 O O   . VAL B 2 61  ? 150.427 149.710 126.721 1.00 45.70  ?  43  VAL B O   1 
ATOM   3777 C CB  . VAL B 2 61  ? 152.288 151.236 124.373 1.00 45.70  ?  43  VAL B CB  1 
ATOM   3778 C CG1 . VAL B 2 61  ? 152.699 151.797 125.724 1.00 45.70  ?  43  VAL B CG1 1 
ATOM   3779 C CG2 . VAL B 2 61  ? 153.515 150.872 123.575 1.00 45.70  ?  43  VAL B CG2 1 
ATOM   3780 N N   . CYS B 2 62  ? 149.234 150.946 125.265 1.00 47.80  ?  44  CYS B N   1 
ATOM   3781 C CA  . CYS B 2 62  ? 148.174 151.182 126.235 1.00 47.80  ?  44  CYS B CA  1 
ATOM   3782 C C   . CYS B 2 62  ? 147.403 149.912 126.562 1.00 47.80  ?  44  CYS B C   1 
ATOM   3783 O O   . CYS B 2 62  ? 146.976 149.745 127.703 1.00 47.80  ?  44  CYS B O   1 
ATOM   3784 C CB  . CYS B 2 62  ? 147.227 152.265 125.733 1.00 47.80  ?  44  CYS B CB  1 
ATOM   3785 S SG  . CYS B 2 62  ? 147.801 153.936 126.089 1.00 47.80  ?  44  CYS B SG  1 
ATOM   3786 N N   . LEU B 2 63  ? 147.269 148.988 125.605 1.00 46.03  ?  45  LEU B N   1 
ATOM   3787 C CA  . LEU B 2 63  ? 146.614 147.713 125.885 1.00 46.03  ?  45  LEU B CA  1 
ATOM   3788 C C   . LEU B 2 63  ? 147.422 146.866 126.859 1.00 46.03  ?  45  LEU B C   1 
ATOM   3789 O O   . LEU B 2 63  ? 146.872 146.350 127.843 1.00 46.03  ?  45  LEU B O   1 
ATOM   3790 C CB  . LEU B 2 63  ? 146.382 146.946 124.586 1.00 46.03  ?  45  LEU B CB  1 
ATOM   3791 C CG  . LEU B 2 63  ? 145.023 147.151 123.919 1.00 46.03  ?  45  LEU B CG  1 
ATOM   3792 C CD1 . LEU B 2 63  ? 145.062 146.701 122.470 1.00 46.03  ?  45  LEU B CD1 1 
ATOM   3793 C CD2 . LEU B 2 63  ? 143.939 146.420 124.686 1.00 46.03  ?  45  LEU B CD2 1 
ATOM   3794 N N   . ILE B 2 64  ? 148.734 146.746 126.625 1.00 46.01  ?  46  ILE B N   1 
ATOM   3795 C CA  . ILE B 2 64  ? 149.566 145.924 127.503 1.00 46.01  ?  46  ILE B CA  1 
ATOM   3796 C C   . ILE B 2 64  ? 149.694 146.556 128.889 1.00 46.01  ?  46  ILE B C   1 
ATOM   3797 O O   . ILE B 2 64  ? 149.594 145.860 129.907 1.00 46.01  ?  46  ILE B O   1 
ATOM   3798 C CB  . ILE B 2 64  ? 150.942 145.664 126.860 1.00 46.01  ?  46  ILE B CB  1 
ATOM   3799 C CG1 . ILE B 2 64  ? 150.775 144.953 125.520 1.00 46.01  ?  46  ILE B CG1 1 
ATOM   3800 C CG2 . ILE B 2 64  ? 151.805 144.801 127.762 1.00 46.01  ?  46  ILE B CG2 1 
ATOM   3801 C CD1 . ILE B 2 64  ? 152.071 144.708 124.792 1.00 46.01  ?  46  ILE B CD1 1 
ATOM   3802 N N   . VAL B 2 65  ? 149.862 147.882 128.958 1.00 44.45  ?  47  VAL B N   1 
ATOM   3803 C CA  . VAL B 2 65  ? 150.005 148.544 130.254 1.00 44.45  ?  47  VAL B CA  1 
ATOM   3804 C C   . VAL B 2 65  ? 148.682 148.535 131.020 1.00 44.45  ?  47  VAL B C   1 
ATOM   3805 O O   . VAL B 2 65  ? 148.656 148.275 132.229 1.00 44.45  ?  47  VAL B O   1 
ATOM   3806 C CB  . VAL B 2 65  ? 150.562 149.969 130.061 1.00 44.45  ?  47  VAL B CB  1 
ATOM   3807 C CG1 . VAL B 2 65  ? 150.472 150.785 131.336 1.00 44.45  ?  47  VAL B CG1 1 
ATOM   3808 C CG2 . VAL B 2 65  ? 152.004 149.907 129.608 1.00 44.45  ?  47  VAL B CG2 1 
ATOM   3809 N N   . GLY B 2 66  ? 147.559 148.749 130.330 1.00 45.66  ?  48  GLY B N   1 
ATOM   3810 C CA  . GLY B 2 66  ? 146.271 148.728 130.990 1.00 45.66  ?  48  GLY B CA  1 
ATOM   3811 C C   . GLY B 2 66  ? 145.790 147.350 131.381 1.00 45.66  ?  48  GLY B C   1 
ATOM   3812 O O   . GLY B 2 66  ? 144.889 147.240 132.217 1.00 45.66  ?  48  GLY B O   1 
ATOM   3813 N N   . ASN B 2 67  ? 146.352 146.294 130.795 1.00 47.45  ?  49  ASN B N   1 
ATOM   3814 C CA  . ASN B 2 67  ? 146.029 144.970 131.307 1.00 47.45  ?  49  ASN B CA  1 
ATOM   3815 C C   . ASN B 2 67  ? 147.008 144.486 132.368 1.00 47.45  ?  49  ASN B C   1 
ATOM   3816 O O   . ASN B 2 67  ? 146.630 143.670 133.214 1.00 47.45  ?  49  ASN B O   1 
ATOM   3817 C CB  . ASN B 2 67  ? 145.969 143.952 130.169 1.00 47.45  ?  49  ASN B CB  1 
ATOM   3818 C CG  . ASN B 2 67  ? 144.969 142.851 130.437 1.00 47.45  ?  49  ASN B CG  1 
ATOM   3819 O OD1 . ASN B 2 67  ? 143.919 143.083 131.030 1.00 47.45  ?  49  ASN B OD1 1 
ATOM   3820 N ND2 . ASN B 2 67  ? 145.292 141.643 130.006 1.00 47.45  ?  49  ASN B ND2 1 
ATOM   3821 N N   . MET B 2 68  ? 148.254 144.962 132.351 1.00 49.28  ?  50  MET B N   1 
ATOM   3822 C CA  . MET B 2 68  ? 149.217 144.520 133.353 1.00 49.28  ?  50  MET B CA  1 
ATOM   3823 C C   . MET B 2 68  ? 148.999 145.223 134.687 1.00 49.28  ?  50  MET B C   1 
ATOM   3824 O O   . MET B 2 68  ? 148.945 144.574 135.735 1.00 49.28  ?  50  MET B O   1 
ATOM   3825 C CB  . MET B 2 68  ? 150.643 144.747 132.855 1.00 49.28  ?  50  MET B CB  1 
ATOM   3826 C CG  . MET B 2 68  ? 151.147 143.663 131.930 1.00 49.28  ?  50  MET B CG  1 
ATOM   3827 S SD  . MET B 2 68  ? 152.845 143.927 131.418 1.00 49.28  ?  50  MET B SD  1 
ATOM   3828 C CE  . MET B 2 68  ? 153.723 143.371 132.869 1.00 49.28  ?  50  MET B CE  1 
ATOM   3829 N N   . ILE B 2 69  ? 148.877 146.546 134.671 1.00 49.17  ?  51  ILE B N   1 
ATOM   3830 C CA  . ILE B 2 69  ? 148.614 147.302 135.889 1.00 49.17  ?  51  ILE B CA  1 
ATOM   3831 C C   . ILE B 2 69  ? 147.121 147.219 136.182 1.00 49.17  ?  51  ILE B C   1 
ATOM   3832 O O   . ILE B 2 69  ? 146.295 147.697 135.402 1.00 49.17  ?  51  ILE B O   1 
ATOM   3833 C CB  . ILE B 2 69  ? 149.072 148.758 135.766 1.00 49.17  ?  51  ILE B CB  1 
ATOM   3834 C CG1 . ILE B 2 69  ? 150.592 148.831 135.665 1.00 49.17  ?  51  ILE B CG1 1 
ATOM   3835 C CG2 . ILE B 2 69  ? 148.590 149.560 136.955 1.00 49.17  ?  51  ILE B CG2 1 
ATOM   3836 C CD1 . ILE B 2 69  ? 151.093 150.159 135.182 1.00 49.17  ?  51  ILE B CD1 1 
ATOM   3837 N N   . GLY B 2 70  ? 146.772 146.608 137.307 1.00 55.59  ?  52  GLY B N   1 
ATOM   3838 C CA  . GLY B 2 70  ? 145.387 146.504 137.710 1.00 55.59  ?  52  GLY B CA  1 
ATOM   3839 C C   . GLY B 2 70  ? 145.215 146.789 139.185 1.00 55.59  ?  52  GLY B C   1 
ATOM   3840 O O   . GLY B 2 70  ? 145.857 147.693 139.725 1.00 55.59  ?  52  GLY B O   1 
ATOM   3841 N N   . SER B 2 71  ? 144.363 146.022 139.853 1.00 57.92  ?  53  SER B N   1 
ATOM   3842 C CA  . SER B 2 71  ? 144.128 146.218 141.274 1.00 57.92  ?  53  SER B CA  1 
ATOM   3843 C C   . SER B 2 71  ? 145.198 145.584 142.152 1.00 57.92  ?  53  SER B C   1 
ATOM   3844 O O   . SER B 2 71  ? 145.193 145.818 143.363 1.00 57.92  ?  53  SER B O   1 
ATOM   3845 C CB  . SER B 2 71  ? 142.752 145.666 141.663 1.00 57.92  ?  53  SER B CB  1 
ATOM   3846 O OG  . SER B 2 71  ? 142.629 144.301 141.311 1.00 57.92  ?  53  SER B OG  1 
ATOM   3847 N N   . GLY B 2 72  ? 146.114 144.804 141.578 1.00 56.07  ?  54  GLY B N   1 
ATOM   3848 C CA  . GLY B 2 72  ? 147.109 144.123 142.391 1.00 56.07  ?  54  GLY B CA  1 
ATOM   3849 C C   . GLY B 2 72  ? 148.158 145.056 142.963 1.00 56.07  ?  54  GLY B C   1 
ATOM   3850 O O   . GLY B 2 72  ? 148.626 144.860 144.086 1.00 56.07  ?  54  GLY B O   1 
ATOM   3851 N N   . ILE B 2 73  ? 148.543 146.084 142.205 1.00 53.54  ?  55  ILE B N   1 
ATOM   3852 C CA  . ILE B 2 73  ? 149.485 147.072 142.720 1.00 53.54  ?  55  ILE B CA  1 
ATOM   3853 C C   . ILE B 2 73  ? 148.811 148.014 143.712 1.00 53.54  ?  55  ILE B C   1 
ATOM   3854 O O   . ILE B 2 73  ? 149.493 148.651 144.523 1.00 53.54  ?  55  ILE B O   1 
ATOM   3855 C CB  . ILE B 2 73  ? 150.136 147.832 141.546 1.00 53.54  ?  55  ILE B CB  1 
ATOM   3856 C CG1 . ILE B 2 73  ? 151.430 148.538 141.968 1.00 53.54  ?  55  ILE B CG1 1 
ATOM   3857 C CG2 . ILE B 2 73  ? 149.170 148.822 140.917 1.00 53.54  ?  55  ILE B CG2 1 
ATOM   3858 C CD1 . ILE B 2 73  ? 152.418 147.646 142.671 1.00 53.54  ?  55  ILE B CD1 1 
ATOM   3859 N N   . PHE B 2 74  ? 147.483 148.082 143.705 1.00 54.87  ?  56  PHE B N   1 
ATOM   3860 C CA  . PHE B 2 74  ? 146.744 149.013 144.542 1.00 54.87  ?  56  PHE B CA  1 
ATOM   3861 C C   . PHE B 2 74  ? 146.249 148.385 145.836 1.00 54.87  ?  56  PHE B C   1 
ATOM   3862 O O   . PHE B 2 74  ? 146.509 148.919 146.915 1.00 54.87  ?  56  PHE B O   1 
ATOM   3863 C CB  . PHE B 2 74  ? 145.554 149.579 143.763 1.00 54.87  ?  56  PHE B CB  1 
ATOM   3864 C CG  . PHE B 2 74  ? 145.917 150.675 142.811 1.00 54.87  ?  56  PHE B CG  1 
ATOM   3865 C CD1 . PHE B 2 74  ? 146.465 151.857 143.273 1.00 54.87  ?  56  PHE B CD1 1 
ATOM   3866 C CD2 . PHE B 2 74  ? 145.699 150.525 141.451 1.00 54.87  ?  56  PHE B CD2 1 
ATOM   3867 C CE1 . PHE B 2 74  ? 146.792 152.873 142.397 1.00 54.87  ?  56  PHE B CE1 1 
ATOM   3868 C CE2 . PHE B 2 74  ? 146.028 151.534 140.569 1.00 54.87  ?  56  PHE B CE2 1 
ATOM   3869 C CZ  . PHE B 2 74  ? 146.576 152.710 141.043 1.00 54.87  ?  56  PHE B CZ  1 
ATOM   3870 N N   . VAL B 2 75  ? 145.537 147.262 145.757 1.00 57.46  ?  57  VAL B N   1 
ATOM   3871 C CA  . VAL B 2 75  ? 144.855 146.739 146.934 1.00 57.46  ?  57  VAL B CA  1 
ATOM   3872 C C   . VAL B 2 75  ? 145.660 145.675 147.677 1.00 57.46  ?  57  VAL B C   1 
ATOM   3873 O O   . VAL B 2 75  ? 145.428 145.478 148.879 1.00 57.46  ?  57  VAL B O   1 
ATOM   3874 C CB  . VAL B 2 75  ? 143.447 146.203 146.580 1.00 57.46  ?  57  VAL B CB  1 
ATOM   3875 C CG1 . VAL B 2 75  ? 142.725 147.172 145.657 1.00 57.46  ?  57  VAL B CG1 1 
ATOM   3876 C CG2 . VAL B 2 75  ? 143.485 144.807 145.983 1.00 57.46  ?  57  VAL B CG2 1 
ATOM   3877 N N   . SER B 2 76  ? 146.615 145.011 147.020 1.00 59.64  ?  58  SER B N   1 
ATOM   3878 C CA  . SER B 2 76  ? 147.358 143.968 147.721 1.00 59.64  ?  58  SER B CA  1 
ATOM   3879 C C   . SER B 2 76  ? 148.746 143.698 147.151 1.00 59.64  ?  58  SER B C   1 
ATOM   3880 O O   . SER B 2 76  ? 148.941 142.673 146.487 1.00 59.64  ?  58  SER B O   1 
ATOM   3881 C CB  . SER B 2 76  ? 146.561 142.663 147.703 1.00 59.64  ?  58  SER B CB  1 
ATOM   3882 O OG  . SER B 2 76  ? 146.069 142.395 146.404 1.00 59.64  ?  58  SER B OG  1 
ATOM   3883 N N   . PRO B 2 77  ? 149.748 144.571 147.386 1.00 60.46  ?  59  PRO B N   1 
ATOM   3884 C CA  . PRO B 2 77  ? 151.149 144.168 147.238 1.00 60.46  ?  59  PRO B CA  1 
ATOM   3885 C C   . PRO B 2 77  ? 151.717 143.611 148.543 1.00 60.46  ?  59  PRO B C   1 
ATOM   3886 O O   . PRO B 2 77  ? 152.789 144.016 149.004 1.00 60.46  ?  59  PRO B O   1 
ATOM   3887 C CB  . PRO B 2 77  ? 151.831 145.474 146.821 1.00 60.46  ?  59  PRO B CB  1 
ATOM   3888 C CG  . PRO B 2 77  ? 151.069 146.506 147.547 1.00 60.46  ?  59  PRO B CG  1 
ATOM   3889 C CD  . PRO B 2 77  ? 149.647 146.014 147.672 1.00 60.46  ?  59  PRO B CD  1 
ATOM   3890 N N   . LYS B 2 78  ? 150.992 142.670 149.152 1.00 63.42  ?  60  LYS B N   1 
ATOM   3891 C CA  . LYS B 2 78  ? 151.294 142.201 150.494 1.00 63.42  ?  60  LYS B CA  1 
ATOM   3892 C C   . LYS B 2 78  ? 151.958 140.838 150.546 1.00 63.42  ?  60  LYS B C   1 
ATOM   3893 O O   . LYS B 2 78  ? 152.555 140.511 151.576 1.00 63.42  ?  60  LYS B O   1 
ATOM   3894 C CB  . LYS B 2 78  ? 150.014 142.134 151.337 1.00 63.42  ?  60  LYS B CB  1 
ATOM   3895 C CG  . LYS B 2 78  ? 149.502 143.469 151.814 1.00 63.42  ?  60  LYS B CG  1 
ATOM   3896 C CD  . LYS B 2 78  ? 148.627 143.293 153.036 1.00 63.42  ?  60  LYS B CD  1 
ATOM   3897 C CE  . LYS B 2 78  ? 147.438 142.397 152.762 1.00 63.42  ?  60  LYS B CE  1 
ATOM   3898 N NZ  . LYS B 2 78  ? 146.657 142.150 154.003 1.00 63.42  1  60  LYS B NZ  1 
ATOM   3899 N N   . GLY B 2 79  ? 151.857 140.036 149.484 1.00 62.67  ?  61  GLY B N   1 
ATOM   3900 C CA  . GLY B 2 79  ? 152.402 138.688 149.526 1.00 62.67  ?  61  GLY B CA  1 
ATOM   3901 C C   . GLY B 2 79  ? 153.916 138.670 149.572 1.00 62.67  ?  61  GLY B C   1 
ATOM   3902 O O   . GLY B 2 79  ? 154.515 137.881 150.313 1.00 62.67  ?  61  GLY B O   1 
ATOM   3903 N N   . VAL B 2 80  ? 154.551 139.563 148.811 1.00 61.25  ?  62  VAL B N   1 
ATOM   3904 C CA  . VAL B 2 80  ? 156.006 139.667 148.797 1.00 61.25  ?  62  VAL B CA  1 
ATOM   3905 C C   . VAL B 2 80  ? 156.527 140.109 150.158 1.00 61.25  ?  62  VAL B C   1 
ATOM   3906 O O   . VAL B 2 80  ? 157.547 139.606 150.641 1.00 61.25  ?  62  VAL B O   1 
ATOM   3907 C CB  . VAL B 2 80  ? 156.437 140.629 147.677 1.00 61.25  ?  62  VAL B CB  1 
ATOM   3908 C CG1 . VAL B 2 80  ? 157.943 140.664 147.540 1.00 61.25  ?  62  VAL B CG1 1 
ATOM   3909 C CG2 . VAL B 2 80  ? 155.789 140.225 146.376 1.00 61.25  ?  62  VAL B CG2 1 
ATOM   3910 N N   . LEU B 2 81  ? 155.806 141.010 150.823 1.00 61.79  ?  63  LEU B N   1 
ATOM   3911 C CA  . LEU B 2 81  ? 156.242 141.478 152.131 1.00 61.79  ?  63  LEU B CA  1 
ATOM   3912 C C   . LEU B 2 81  ? 155.967 140.456 153.227 1.00 61.79  ?  63  LEU B C   1 
ATOM   3913 O O   . LEU B 2 81  ? 156.765 140.331 154.161 1.00 61.79  ?  63  LEU B O   1 
ATOM   3914 C CB  . LEU B 2 81  ? 155.569 142.808 152.456 1.00 61.79  ?  63  LEU B CB  1 
ATOM   3915 C CG  . LEU B 2 81  ? 156.196 143.602 153.596 1.00 61.79  ?  63  LEU B CG  1 
ATOM   3916 C CD1 . LEU B 2 81  ? 157.657 143.851 153.324 1.00 61.79  ?  63  LEU B CD1 1 
ATOM   3917 C CD2 . LEU B 2 81  ? 155.476 144.909 153.767 1.00 61.79  ?  63  LEU B CD2 1 
ATOM   3918 N N   . ILE B 2 82  ? 154.861 139.712 153.142 1.00 63.96  ?  64  ILE B N   1 
ATOM   3919 C CA  . ILE B 2 82  ? 154.565 138.746 154.196 1.00 63.96  ?  64  ILE B CA  1 
ATOM   3920 C C   . ILE B 2 82  ? 155.418 137.487 154.060 1.00 63.96  ?  64  ILE B C   1 
ATOM   3921 O O   . ILE B 2 82  ? 155.718 136.841 155.071 1.00 63.96  ?  64  ILE B O   1 
ATOM   3922 C CB  . ILE B 2 82  ? 153.056 138.426 154.241 1.00 63.96  ?  64  ILE B CB  1 
ATOM   3923 C CG1 . ILE B 2 82  ? 152.670 137.717 155.543 1.00 63.96  ?  64  ILE B CG1 1 
ATOM   3924 C CG2 . ILE B 2 82  ? 152.617 137.564 153.074 1.00 63.96  ?  64  ILE B CG2 1 
ATOM   3925 C CD1 . ILE B 2 82  ? 152.866 138.545 156.788 1.00 63.96  ?  64  ILE B CD1 1 
ATOM   3926 N N   . TYR B 2 83  ? 155.882 137.148 152.856 1.00 65.69  ?  65  TYR B N   1 
ATOM   3927 C CA  . TYR B 2 83  ? 156.790 136.022 152.718 1.00 65.69  ?  65  TYR B CA  1 
ATOM   3928 C C   . TYR B 2 83  ? 158.250 136.440 152.713 1.00 65.69  ?  65  TYR B C   1 
ATOM   3929 O O   . TYR B 2 83  ? 159.125 135.576 152.801 1.00 65.69  ?  65  TYR B O   1 
ATOM   3930 C CB  . TYR B 2 83  ? 156.472 135.236 151.445 1.00 65.69  ?  65  TYR B CB  1 
ATOM   3931 C CG  . TYR B 2 83  ? 155.161 134.498 151.522 1.00 65.69  ?  65  TYR B CG  1 
ATOM   3932 C CD1 . TYR B 2 83  ? 154.938 133.550 152.508 1.00 65.69  ?  65  TYR B CD1 1 
ATOM   3933 C CD2 . TYR B 2 83  ? 154.145 134.751 150.613 1.00 65.69  ?  65  TYR B CD2 1 
ATOM   3934 C CE1 . TYR B 2 83  ? 153.737 132.874 152.586 1.00 65.69  ?  65  TYR B CE1 1 
ATOM   3935 C CE2 . TYR B 2 83  ? 152.943 134.082 150.682 1.00 65.69  ?  65  TYR B CE2 1 
ATOM   3936 C CZ  . TYR B 2 83  ? 152.746 133.144 151.669 1.00 65.69  ?  65  TYR B CZ  1 
ATOM   3937 O OH  . TYR B 2 83  ? 151.548 132.474 151.739 1.00 65.69  ?  65  TYR B OH  1 
ATOM   3938 N N   . SER B 2 84  ? 158.533 137.735 152.627 1.00 63.85  ?  66  SER B N   1 
ATOM   3939 C CA  . SER B 2 84  ? 159.895 138.236 152.592 1.00 63.85  ?  66  SER B CA  1 
ATOM   3940 C C   . SER B 2 84  ? 160.365 138.828 153.910 1.00 63.85  ?  66  SER B C   1 
ATOM   3941 O O   . SER B 2 84  ? 161.562 138.774 154.198 1.00 63.85  ?  66  SER B O   1 
ATOM   3942 C CB  . SER B 2 84  ? 160.024 139.295 151.493 1.00 63.85  ?  66  SER B CB  1 
ATOM   3943 O OG  . SER B 2 84  ? 161.315 139.855 151.475 1.00 63.85  ?  66  SER B OG  1 
ATOM   3944 N N   . ALA B 2 85  ? 159.449 139.417 154.689 1.00 64.84  ?  67  ALA B N   1 
ATOM   3945 C CA  . ALA B 2 85  ? 159.665 139.940 156.043 1.00 64.84  ?  67  ALA B CA  1 
ATOM   3946 C C   . ALA B 2 85  ? 160.711 141.050 156.111 1.00 64.84  ?  67  ALA B C   1 
ATOM   3947 O O   . ALA B 2 85  ? 161.266 141.310 157.180 1.00 64.84  ?  67  ALA B O   1 
ATOM   3948 C CB  . ALA B 2 85  ? 160.022 138.821 157.030 1.00 64.84  ?  67  ALA B CB  1 
ATOM   3949 N N   . SER B 2 86  ? 160.977 141.729 154.998 1.00 64.35  ?  68  SER B N   1 
ATOM   3950 C CA  . SER B 2 86  ? 161.930 142.829 154.969 1.00 64.35  ?  68  SER B CA  1 
ATOM   3951 C C   . SER B 2 86  ? 161.598 143.718 153.783 1.00 64.35  ?  68  SER B C   1 
ATOM   3952 O O   . SER B 2 86  ? 160.908 143.302 152.852 1.00 64.35  ?  68  SER B O   1 
ATOM   3953 C CB  . SER B 2 86  ? 163.372 142.328 154.875 1.00 64.35  ?  68  SER B CB  1 
ATOM   3954 O OG  . SER B 2 86  ? 164.283 143.336 155.268 1.00 64.35  ?  68  SER B OG  1 
ATOM   3955 N N   . PHE B 2 87  ? 162.101 144.950 153.825 1.00 59.93  ?  69  PHE B N   1 
ATOM   3956 C CA  . PHE B 2 87  ? 161.822 145.896 152.751 1.00 59.93  ?  69  PHE B CA  1 
ATOM   3957 C C   . PHE B 2 87  ? 162.747 145.680 151.559 1.00 59.93  ?  69  PHE B C   1 
ATOM   3958 O O   . PHE B 2 87  ? 162.288 145.605 150.409 1.00 59.93  ?  69  PHE B O   1 
ATOM   3959 C CB  . PHE B 2 87  ? 161.949 147.329 153.269 1.00 59.93  ?  69  PHE B CB  1 
ATOM   3960 C CG  . PHE B 2 87  ? 160.770 147.796 154.077 1.00 59.93  ?  69  PHE B CG  1 
ATOM   3961 C CD1 . PHE B 2 87  ? 159.570 147.104 154.054 1.00 59.93  ?  69  PHE B CD1 1 
ATOM   3962 C CD2 . PHE B 2 87  ? 160.863 148.935 154.857 1.00 59.93  ?  69  PHE B CD2 1 
ATOM   3963 C CE1 . PHE B 2 87  ? 158.489 147.539 154.795 1.00 59.93  ?  69  PHE B CE1 1 
ATOM   3964 C CE2 . PHE B 2 87  ? 159.785 149.373 155.600 1.00 59.93  ?  69  PHE B CE2 1 
ATOM   3965 C CZ  . PHE B 2 87  ? 158.599 148.674 155.567 1.00 59.93  ?  69  PHE B CZ  1 
ATOM   3966 N N   . GLY B 2 88  ? 164.054 145.584 151.820 1.00 60.44  ?  70  GLY B N   1 
ATOM   3967 C CA  . GLY B 2 88  ? 165.022 145.445 150.746 1.00 60.44  ?  70  GLY B CA  1 
ATOM   3968 C C   . GLY B 2 88  ? 164.917 144.131 150.004 1.00 60.44  ?  70  GLY B C   1 
ATOM   3969 O O   . GLY B 2 88  ? 165.047 144.096 148.775 1.00 60.44  ?  70  GLY B O   1 
ATOM   3970 N N   . LEU B 2 89  ? 164.650 143.042 150.726 1.00 59.73  ?  71  LEU B N   1 
ATOM   3971 C CA  . LEU B 2 89  ? 164.441 141.760 150.067 1.00 59.73  ?  71  LEU B CA  1 
ATOM   3972 C C   . LEU B 2 89  ? 163.150 141.753 149.258 1.00 59.73  ?  71  LEU B C   1 
ATOM   3973 O O   . LEU B 2 89  ? 163.090 141.109 148.205 1.00 59.73  ?  71  LEU B O   1 
ATOM   3974 C CB  . LEU B 2 89  ? 164.445 140.636 151.098 1.00 59.73  ?  71  LEU B CB  1 
ATOM   3975 C CG  . LEU B 2 89  ? 164.529 139.215 150.542 1.00 59.73  ?  71  LEU B CG  1 
ATOM   3976 C CD1 . LEU B 2 89  ? 165.894 138.971 149.940 1.00 59.73  ?  71  LEU B CD1 1 
ATOM   3977 C CD2 . LEU B 2 89  ? 164.221 138.190 151.616 1.00 59.73  ?  71  LEU B CD2 1 
ATOM   3978 N N   . SER B 2 90  ? 162.132 142.493 149.706 1.00 57.85  ?  72  SER B N   1 
ATOM   3979 C CA  . SER B 2 90  ? 160.910 142.637 148.919 1.00 57.85  ?  72  SER B CA  1 
ATOM   3980 C C   . SER B 2 90  ? 161.169 143.376 147.614 1.00 57.85  ?  72  SER B C   1 
ATOM   3981 O O   . SER B 2 90  ? 160.669 142.968 146.560 1.00 57.85  ?  72  SER B O   1 
ATOM   3982 C CB  . SER B 2 90  ? 159.843 143.360 149.731 1.00 57.85  ?  72  SER B CB  1 
ATOM   3983 O OG  . SER B 2 90  ? 159.461 142.580 150.843 1.00 57.85  ?  72  SER B OG  1 
ATOM   3984 N N   . LEU B 2 91  ? 161.963 144.451 147.661 1.00 53.53  ?  73  LEU B N   1 
ATOM   3985 C CA  . LEU B 2 91  ? 162.317 145.159 146.431 1.00 53.53  ?  73  LEU B CA  1 
ATOM   3986 C C   . LEU B 2 91  ? 163.161 144.295 145.496 1.00 53.53  ?  73  LEU B C   1 
ATOM   3987 O O   . LEU B 2 91  ? 162.994 144.364 144.267 1.00 53.53  ?  73  LEU B O   1 
ATOM   3988 C CB  . LEU B 2 91  ? 163.050 146.453 146.770 1.00 53.53  ?  73  LEU B CB  1 
ATOM   3989 C CG  . LEU B 2 91  ? 162.230 147.456 147.580 1.00 53.53  ?  73  LEU B CG  1 
ATOM   3990 C CD1 . LEU B 2 91  ? 163.050 148.686 147.900 1.00 53.53  ?  73  LEU B CD1 1 
ATOM   3991 C CD2 . LEU B 2 91  ? 160.968 147.833 146.830 1.00 53.53  ?  73  LEU B CD2 1 
ATOM   3992 N N   . VAL B 2 92  ? 164.037 143.458 146.063 1.00 53.20  ?  74  VAL B N   1 
ATOM   3993 C CA  . VAL B 2 92  ? 164.819 142.514 145.267 1.00 53.20  ?  74  VAL B CA  1 
ATOM   3994 C C   . VAL B 2 92  ? 163.908 141.507 144.566 1.00 53.20  ?  74  VAL B C   1 
ATOM   3995 O O   . VAL B 2 92  ? 164.075 141.230 143.369 1.00 53.20  ?  74  VAL B O   1 
ATOM   3996 C CB  . VAL B 2 92  ? 165.869 141.827 146.163 1.00 53.20  ?  74  VAL B CB  1 
ATOM   3997 C CG1 . VAL B 2 92  ? 166.406 140.558 145.527 1.00 53.20  ?  74  VAL B CG1 1 
ATOM   3998 C CG2 . VAL B 2 92  ? 167.012 142.777 146.455 1.00 53.20  ?  74  VAL B CG2 1 
ATOM   3999 N N   . ILE B 2 93  ? 162.907 140.983 145.283 1.00 53.88  ?  75  ILE B N   1 
ATOM   4000 C CA  . ILE B 2 93  ? 161.985 140.006 144.703 1.00 53.88  ?  75  ILE B CA  1 
ATOM   4001 C C   . ILE B 2 93  ? 161.125 140.650 143.614 1.00 53.88  ?  75  ILE B C   1 
ATOM   4002 O O   . ILE B 2 93  ? 160.850 140.029 142.577 1.00 53.88  ?  75  ILE B O   1 
ATOM   4003 C CB  . ILE B 2 93  ? 161.137 139.359 145.818 1.00 53.88  ?  75  ILE B CB  1 
ATOM   4004 C CG1 . ILE B 2 93  ? 162.004 138.455 146.694 1.00 53.88  ?  75  ILE B CG1 1 
ATOM   4005 C CG2 . ILE B 2 93  ? 159.997 138.522 145.267 1.00 53.88  ?  75  ILE B CG2 1 
ATOM   4006 C CD1 . ILE B 2 93  ? 162.653 137.318 145.952 1.00 53.88  ?  75  ILE B CD1 1 
ATOM   4007 N N   . TRP B 2 94  ? 160.750 141.923 143.800 1.00 51.54  ?  76  TRP B N   1 
ATOM   4008 C CA  . TRP B 2 94  ? 159.992 142.643 142.774 1.00 51.54  ?  76  TRP B CA  1 
ATOM   4009 C C   . TRP B 2 94  ? 160.804 142.818 141.491 1.00 51.54  ?  76  TRP B C   1 
ATOM   4010 O O   . TRP B 2 94  ? 160.292 142.582 140.384 1.00 51.54  ?  76  TRP B O   1 
ATOM   4011 C CB  . TRP B 2 94  ? 159.544 144.006 143.307 1.00 51.54  ?  76  TRP B CB  1 
ATOM   4012 C CG  . TRP B 2 94  ? 158.269 143.987 144.111 1.00 51.54  ?  76  TRP B CG  1 
ATOM   4013 C CD1 . TRP B 2 94  ? 158.135 144.262 145.437 1.00 51.54  ?  76  TRP B CD1 1 
ATOM   4014 C CD2 . TRP B 2 94  ? 156.952 143.692 143.633 1.00 51.54  ?  76  TRP B CD2 1 
ATOM   4015 N NE1 . TRP B 2 94  ? 156.827 144.145 145.820 1.00 51.54  ?  76  TRP B NE1 1 
ATOM   4016 C CE2 . TRP B 2 94  ? 156.077 143.798 144.730 1.00 51.54  ?  76  TRP B CE2 1 
ATOM   4017 C CE3 . TRP B 2 94  ? 156.428 143.349 142.387 1.00 51.54  ?  76  TRP B CE3 1 
ATOM   4018 C CZ2 . TRP B 2 94  ? 154.712 143.571 144.618 1.00 51.54  ?  76  TRP B CZ2 1 
ATOM   4019 C CZ3 . TRP B 2 94  ? 155.073 143.125 142.279 1.00 51.54  ?  76  TRP B CZ3 1 
ATOM   4020 C CH2 . TRP B 2 94  ? 154.230 143.237 143.386 1.00 51.54  ?  76  TRP B CH2 1 
ATOM   4021 N N   . ALA B 2 95  ? 162.084 143.188 141.624 1.00 51.57  ?  77  ALA B N   1 
ATOM   4022 C CA  . ALA B 2 95  ? 162.941 143.336 140.446 1.00 51.57  ?  77  ALA B CA  1 
ATOM   4023 C C   . ALA B 2 95  ? 163.188 142.000 139.744 1.00 51.57  ?  77  ALA B C   1 
ATOM   4024 O O   . ALA B 2 95  ? 163.212 141.937 138.505 1.00 51.57  ?  77  ALA B O   1 
ATOM   4025 C CB  . ALA B 2 95  ? 164.264 143.983 140.843 1.00 51.57  ?  77  ALA B CB  1 
ATOM   4026 N N   . VAL B 2 96  ? 163.344 140.919 140.514 1.00 52.21  ?  78  VAL B N   1 
ATOM   4027 C CA  . VAL B 2 96  ? 163.617 139.612 139.916 1.00 52.21  ?  78  VAL B CA  1 
ATOM   4028 C C   . VAL B 2 96  ? 162.381 139.082 139.189 1.00 52.21  ?  78  VAL B C   1 
ATOM   4029 O O   . VAL B 2 96  ? 162.486 138.501 138.097 1.00 52.21  ?  78  VAL B O   1 
ATOM   4030 C CB  . VAL B 2 96  ? 164.135 138.645 141.001 1.00 52.21  ?  78  VAL B CB  1 
ATOM   4031 C CG1 . VAL B 2 96  ? 164.130 137.204 140.534 1.00 52.21  ?  78  VAL B CG1 1 
ATOM   4032 C CG2 . VAL B 2 96  ? 165.540 139.035 141.400 1.00 52.21  ?  78  VAL B CG2 1 
ATOM   4033 N N   . GLY B 2 97  ? 161.191 139.317 139.752 1.00 52.63  ?  79  GLY B N   1 
ATOM   4034 C CA  . GLY B 2 97  ? 159.963 138.974 139.052 1.00 52.63  ?  79  GLY B CA  1 
ATOM   4035 C C   . GLY B 2 97  ? 159.759 139.764 137.774 1.00 52.63  ?  79  GLY B C   1 
ATOM   4036 O O   . GLY B 2 97  ? 159.279 139.218 136.772 1.00 52.63  ?  79  GLY B O   1 
ATOM   4037 N N   . GLY B 2 98  ? 160.149 141.043 137.777 1.00 52.83  ?  80  GLY B N   1 
ATOM   4038 C CA  . GLY B 2 98  ? 160.100 141.821 136.547 1.00 52.83  ?  80  GLY B CA  1 
ATOM   4039 C C   . GLY B 2 98  ? 161.038 141.300 135.471 1.00 52.83  ?  80  GLY B C   1 
ATOM   4040 O O   . GLY B 2 98  ? 160.677 141.256 134.289 1.00 52.83  ?  80  GLY B O   1 
ATOM   4041 N N   . LEU B 2 99  ? 162.240 140.870 135.869 1.00 53.35  ?  81  LEU B N   1 
ATOM   4042 C CA  . LEU B 2 99  ? 163.183 140.292 134.909 1.00 53.35  ?  81  LEU B CA  1 
ATOM   4043 C C   . LEU B 2 99  ? 162.664 138.977 134.328 1.00 53.35  ?  81  LEU B C   1 
ATOM   4044 O O   . LEU B 2 99  ? 162.751 138.740 133.110 1.00 53.35  ?  81  LEU B O   1 
ATOM   4045 C CB  . LEU B 2 99  ? 164.537 140.080 135.581 1.00 53.35  ?  81  LEU B CB  1 
ATOM   4046 C CG  . LEU B 2 99  ? 165.634 139.449 134.728 1.00 53.35  ?  81  LEU B CG  1 
ATOM   4047 C CD1 . LEU B 2 99  ? 166.173 140.456 133.734 1.00 53.35  ?  81  LEU B CD1 1 
ATOM   4048 C CD2 . LEU B 2 99  ? 166.747 138.906 135.603 1.00 53.35  ?  81  LEU B CD2 1 
ATOM   4049 N N   . PHE B 2 100 ? 162.093 138.122 135.179 1.00 54.01  ?  82  PHE B N   1 
ATOM   4050 C CA  . PHE B 2 100 ? 161.565 136.852 134.697 1.00 54.01  ?  82  PHE B CA  1 
ATOM   4051 C C   . PHE B 2 100 ? 160.310 137.019 133.850 1.00 54.01  ?  82  PHE B C   1 
ATOM   4052 O O   . PHE B 2 100 ? 160.006 136.138 133.042 1.00 54.01  ?  82  PHE B O   1 
ATOM   4053 C CB  . PHE B 2 100 ? 161.287 135.914 135.869 1.00 54.01  ?  82  PHE B CB  1 
ATOM   4054 C CG  . PHE B 2 100 ? 162.483 135.120 136.296 1.00 54.01  ?  82  PHE B CG  1 
ATOM   4055 C CD1 . PHE B 2 100 ? 163.030 134.165 135.455 1.00 54.01  ?  82  PHE B CD1 1 
ATOM   4056 C CD2 . PHE B 2 100 ? 163.068 135.334 137.532 1.00 54.01  ?  82  PHE B CD2 1 
ATOM   4057 C CE1 . PHE B 2 100 ? 164.137 133.433 135.843 1.00 54.01  ?  82  PHE B CE1 1 
ATOM   4058 C CE2 . PHE B 2 100 ? 164.174 134.606 137.925 1.00 54.01  ?  82  PHE B CE2 1 
ATOM   4059 C CZ  . PHE B 2 100 ? 164.709 133.656 137.080 1.00 54.01  ?  82  PHE B CZ  1 
ATOM   4060 N N   . SER B 2 101 ? 159.576 138.121 134.005 1.00 52.19  ?  83  SER B N   1 
ATOM   4061 C CA  . SER B 2 101 ? 158.475 138.384 133.085 1.00 52.19  ?  83  SER B CA  1 
ATOM   4062 C C   . SER B 2 101 ? 158.930 138.997 131.766 1.00 52.19  ?  83  SER B C   1 
ATOM   4063 O O   . SER B 2 101 ? 158.279 138.774 130.733 1.00 52.19  ?  83  SER B O   1 
ATOM   4064 C CB  . SER B 2 101 ? 157.441 139.288 133.750 1.00 52.19  ?  83  SER B CB  1 
ATOM   4065 O OG  . SER B 2 101 ? 156.849 138.618 134.843 1.00 52.19  ?  83  SER B OG  1 
ATOM   4066 N N   . VAL B 2 102 ? 160.029 139.762 131.777 1.00 51.82  ?  84  VAL B N   1 
ATOM   4067 C CA  . VAL B 2 102 ? 160.636 140.227 130.527 1.00 51.82  ?  84  VAL B CA  1 
ATOM   4068 C C   . VAL B 2 102 ? 161.094 139.038 129.683 1.00 51.82  ?  84  VAL B C   1 
ATOM   4069 O O   . VAL B 2 102 ? 160.920 139.020 128.451 1.00 51.82  ?  84  VAL B O   1 
ATOM   4070 C CB  . VAL B 2 102 ? 161.791 141.205 130.834 1.00 51.82  ?  84  VAL B CB  1 
ATOM   4071 C CG1 . VAL B 2 102 ? 162.693 141.423 129.631 1.00 51.82  ?  84  VAL B CG1 1 
ATOM   4072 C CG2 . VAL B 2 102 ? 161.241 142.534 131.301 1.00 51.82  ?  84  VAL B CG2 1 
ATOM   4073 N N   . PHE B 2 103 ? 161.634 138.004 130.346 1.00 53.33  ?  85  PHE B N   1 
ATOM   4074 C CA  . PHE B 2 103 ? 162.100 136.809 129.636 1.00 53.33  ?  85  PHE B CA  1 
ATOM   4075 C C   . PHE B 2 103 ? 160.976 136.060 128.920 1.00 53.33  ?  85  PHE B C   1 
ATOM   4076 O O   . PHE B 2 103 ? 161.229 135.395 127.912 1.00 53.33  ?  85  PHE B O   1 
ATOM   4077 C CB  . PHE B 2 103 ? 162.807 135.860 130.602 1.00 53.33  ?  85  PHE B CB  1 
ATOM   4078 C CG  . PHE B 2 103 ? 164.216 136.256 130.926 1.00 53.33  ?  85  PHE B CG  1 
ATOM   4079 C CD1 . PHE B 2 103 ? 164.883 137.196 130.161 1.00 53.33  ?  85  PHE B CD1 1 
ATOM   4080 C CD2 . PHE B 2 103 ? 164.873 135.685 132.001 1.00 53.33  ?  85  PHE B CD2 1 
ATOM   4081 C CE1 . PHE B 2 103 ? 166.176 137.560 130.462 1.00 53.33  ?  85  PHE B CE1 1 
ATOM   4082 C CE2 . PHE B 2 103 ? 166.166 136.045 132.307 1.00 53.33  ?  85  PHE B CE2 1 
ATOM   4083 C CZ  . PHE B 2 103 ? 166.818 136.984 131.536 1.00 53.33  ?  85  PHE B CZ  1 
ATOM   4084 N N   . GLY B 2 104 ? 159.741 136.155 129.407 1.00 51.01  ?  86  GLY B N   1 
ATOM   4085 C CA  . GLY B 2 104 ? 158.622 135.508 128.747 1.00 51.01  ?  86  GLY B CA  1 
ATOM   4086 C C   . GLY B 2 104 ? 157.957 136.385 127.707 1.00 51.01  ?  86  GLY B C   1 
ATOM   4087 O O   . GLY B 2 104 ? 157.444 135.897 126.688 1.00 51.01  ?  86  GLY B O   1 
ATOM   4088 N N   . ALA B 2 105 ? 157.965 137.698 127.967 1.00 49.18  ?  87  ALA B N   1 
ATOM   4089 C CA  . ALA B 2 105 ? 157.441 138.651 126.995 1.00 49.18  ?  87  ALA B CA  1 
ATOM   4090 C C   . ALA B 2 105 ? 158.258 138.654 125.709 1.00 49.18  ?  87  ALA B C   1 
ATOM   4091 O O   . ALA B 2 105 ? 157.696 138.828 124.621 1.00 49.18  ?  87  ALA B O   1 
ATOM   4092 C CB  . ALA B 2 105 ? 157.404 140.050 127.605 1.00 49.18  ?  87  ALA B CB  1 
ATOM   4093 N N   . LEU B 2 106 ? 159.571 138.428 125.807 1.00 49.52  ?  88  LEU B N   1 
ATOM   4094 C CA  . LEU B 2 106 ? 160.389 138.329 124.598 1.00 49.52  ?  88  LEU B CA  1 
ATOM   4095 C C   . LEU B 2 106 ? 160.056 137.075 123.791 1.00 49.52  ?  88  LEU B C   1 
ATOM   4096 O O   . LEU B 2 106 ? 160.040 137.108 122.550 1.00 49.52  ?  88  LEU B O   1 
ATOM   4097 C CB  . LEU B 2 106 ? 161.867 138.351 124.968 1.00 49.52  ?  88  LEU B CB  1 
ATOM   4098 C CG  . LEU B 2 106 ? 162.398 139.719 125.384 1.00 49.52  ?  88  LEU B CG  1 
ATOM   4099 C CD1 . LEU B 2 106 ? 163.821 139.609 125.887 1.00 49.52  ?  88  LEU B CD1 1 
ATOM   4100 C CD2 . LEU B 2 106 ? 162.312 140.682 124.223 1.00 49.52  ?  88  LEU B CD2 1 
ATOM   4101 N N   . CYS B 2 107 ? 159.770 135.967 124.481 1.00 50.13  ?  89  CYS B N   1 
ATOM   4102 C CA  . CYS B 2 107 ? 159.382 134.733 123.805 1.00 50.13  ?  89  CYS B CA  1 
ATOM   4103 C C   . CYS B 2 107 ? 158.051 134.889 123.081 1.00 50.13  ?  89  CYS B C   1 
ATOM   4104 O O   . CYS B 2 107 ? 157.891 134.406 121.952 1.00 50.13  ?  89  CYS B O   1 
ATOM   4105 C CB  . CYS B 2 107 ? 159.308 133.587 124.811 1.00 50.13  ?  89  CYS B CB  1 
ATOM   4106 S SG  . CYS B 2 107 ? 160.876 133.132 125.556 1.00 50.13  ?  89  CYS B SG  1 
ATOM   4107 N N   . TYR B 2 108 ? 157.091 135.582 123.695 1.00 48.23  ?  90  TYR B N   1 
ATOM   4108 C CA  . TYR B 2 108 ? 155.854 135.819 122.955 1.00 48.23  ?  90  TYR B CA  1 
ATOM   4109 C C   . TYR B 2 108 ? 155.989 136.869 121.862 1.00 48.23  ?  90  TYR B C   1 
ATOM   4110 O O   . TYR B 2 108 ? 155.222 136.816 120.898 1.00 48.23  ?  90  TYR B O   1 
ATOM   4111 C CB  . TYR B 2 108 ? 154.688 136.178 123.868 1.00 48.23  ?  90  TYR B CB  1 
ATOM   4112 C CG  . TYR B 2 108 ? 153.954 134.968 124.380 1.00 48.23  ?  90  TYR B CG  1 
ATOM   4113 C CD1 . TYR B 2 108 ? 154.403 133.685 124.104 1.00 48.23  ?  90  TYR B CD1 1 
ATOM   4114 C CD2 . TYR B 2 108 ? 152.736 135.103 125.005 1.00 48.23  ?  90  TYR B CD2 1 
ATOM   4115 C CE1 . TYR B 2 108 ? 153.709 132.581 124.539 1.00 48.23  ?  90  TYR B CE1 1 
ATOM   4116 C CE2 . TYR B 2 108 ? 152.029 134.010 125.436 1.00 48.23  ?  90  TYR B CE2 1 
ATOM   4117 C CZ  . TYR B 2 108 ? 152.516 132.752 125.197 1.00 48.23  ?  90  TYR B CZ  1 
ATOM   4118 O OH  . TYR B 2 108 ? 151.806 131.663 125.629 1.00 48.23  ?  90  TYR B OH  1 
ATOM   4119 N N   . ALA B 2 109 ? 156.947 137.793 121.965 1.00 49.75  ?  91  ALA B N   1 
ATOM   4120 C CA  . ALA B 2 109 ? 157.241 138.668 120.831 1.00 49.75  ?  91  ALA B CA  1 
ATOM   4121 C C   . ALA B 2 109 ? 157.740 137.869 119.632 1.00 49.75  ?  91  ALA B C   1 
ATOM   4122 O O   . ALA B 2 109 ? 157.287 138.083 118.496 1.00 49.75  ?  91  ALA B O   1 
ATOM   4123 C CB  . ALA B 2 109 ? 158.266 139.724 121.234 1.00 49.75  ?  91  ALA B CB  1 
ATOM   4124 N N   . GLU B 2 110 ? 158.637 136.908 119.878 1.00 52.45  ?  92  GLU B N   1 
ATOM   4125 C CA  . GLU B 2 110 ? 159.136 136.071 118.789 1.00 52.45  ?  92  GLU B CA  1 
ATOM   4126 C C   . GLU B 2 110 ? 158.046 135.166 118.220 1.00 52.45  ?  92  GLU B C   1 
ATOM   4127 O O   . GLU B 2 110 ? 157.957 134.996 116.999 1.00 52.45  ?  92  GLU B O   1 
ATOM   4128 C CB  . GLU B 2 110 ? 160.322 135.236 119.260 1.00 52.45  ?  92  GLU B CB  1 
ATOM   4129 C CG  . GLU B 2 110 ? 161.090 134.611 118.115 1.00 52.45  ?  92  GLU B CG  1 
ATOM   4130 C CD  . GLU B 2 110 ? 161.713 133.288 118.480 1.00 52.45  ?  92  GLU B CD  1 
ATOM   4131 O OE1 . GLU B 2 110 ? 161.938 133.051 119.683 1.00 52.45  ?  92  GLU B OE1 1 
ATOM   4132 O OE2 . GLU B 2 110 ? 161.968 132.477 117.566 1.00 52.45  -1 92  GLU B OE2 1 
ATOM   4133 N N   . LEU B 2 111 ? 157.200 134.592 119.083 1.00 48.43  ?  93  LEU B N   1 
ATOM   4134 C CA  . LEU B 2 111 ? 156.110 133.740 118.605 1.00 48.43  ?  93  LEU B CA  1 
ATOM   4135 C C   . LEU B 2 111 ? 155.075 134.529 117.812 1.00 48.43  ?  93  LEU B C   1 
ATOM   4136 O O   . LEU B 2 111 ? 154.544 134.031 116.810 1.00 48.43  ?  93  LEU B O   1 
ATOM   4137 C CB  . LEU B 2 111 ? 155.440 133.034 119.780 1.00 48.43  ?  93  LEU B CB  1 
ATOM   4138 C CG  . LEU B 2 111 ? 155.992 131.676 120.189 1.00 48.43  ?  93  LEU B CG  1 
ATOM   4139 C CD1 . LEU B 2 111 ? 155.444 131.280 121.535 1.00 48.43  ?  93  LEU B CD1 1 
ATOM   4140 C CD2 . LEU B 2 111 ? 155.619 130.648 119.147 1.00 48.43  ?  93  LEU B CD2 1 
ATOM   4141 N N   . GLY B 2 112 ? 154.784 135.760 118.235 1.00 49.40  ?  94  GLY B N   1 
ATOM   4142 C CA  . GLY B 2 112 ? 153.820 136.571 117.518 1.00 49.40  ?  94  GLY B CA  1 
ATOM   4143 C C   . GLY B 2 112 ? 154.332 137.042 116.174 1.00 49.40  ?  94  GLY B C   1 
ATOM   4144 O O   . GLY B 2 112 ? 153.562 137.156 115.219 1.00 49.40  ?  94  GLY B O   1 
ATOM   4145 N N   . THR B 2 113 ? 155.633 137.320 116.072 1.00 52.68  ?  95  THR B N   1 
ATOM   4146 C CA  . THR B 2 113 ? 156.156 137.680 114.760 1.00 52.68  ?  95  THR B CA  1 
ATOM   4147 C C   . THR B 2 113 ? 156.426 136.468 113.879 1.00 52.68  ?  95  THR B C   1 
ATOM   4148 O O   . THR B 2 113 ? 156.527 136.622 112.659 1.00 52.68  ?  95  THR B O   1 
ATOM   4149 C CB  . THR B 2 113 ? 157.428 138.511 114.891 1.00 52.68  ?  95  THR B CB  1 
ATOM   4150 O OG1 . THR B 2 113 ? 158.285 137.930 115.878 1.00 52.68  ?  95  THR B OG1 1 
ATOM   4151 C CG2 . THR B 2 113 ? 157.086 139.929 115.284 1.00 52.68  ?  95  THR B CG2 1 
ATOM   4152 N N   . THR B 2 114 ? 156.536 135.271 114.454 1.00 53.10  ?  96  THR B N   1 
ATOM   4153 C CA  . THR B 2 114 ? 156.756 134.088 113.629 1.00 53.10  ?  96  THR B CA  1 
ATOM   4154 C C   . THR B 2 114 ? 155.447 133.543 113.073 1.00 53.10  ?  96  THR B C   1 
ATOM   4155 O O   . THR B 2 114 ? 155.305 133.377 111.857 1.00 53.10  ?  96  THR B O   1 
ATOM   4156 C CB  . THR B 2 114 ? 157.488 133.010 114.434 1.00 53.10  ?  96  THR B CB  1 
ATOM   4157 O OG1 . THR B 2 114 ? 158.827 133.440 114.696 1.00 53.10  ?  96  THR B OG1 1 
ATOM   4158 C CG2 . THR B 2 114 ? 157.534 131.698 113.672 1.00 53.10  ?  96  THR B CG2 1 
ATOM   4159 N N   . ILE B 2 115 ? 154.476 133.265 113.941 1.00 52.81  ?  97  ILE B N   1 
ATOM   4160 C CA  . ILE B 2 115 ? 153.274 132.578 113.479 1.00 52.81  ?  97  ILE B CA  1 
ATOM   4161 C C   . ILE B 2 115 ? 152.272 133.565 112.888 1.00 52.81  ?  97  ILE B C   1 
ATOM   4162 O O   . ILE B 2 115 ? 151.668 133.292 111.842 1.00 52.81  ?  97  ILE B O   1 
ATOM   4163 C CB  . ILE B 2 115 ? 152.689 131.739 114.629 1.00 52.81  ?  97  ILE B CB  1 
ATOM   4164 C CG1 . ILE B 2 115 ? 153.672 130.617 114.969 1.00 52.81  ?  97  ILE B CG1 1 
ATOM   4165 C CG2 . ILE B 2 115 ? 151.337 131.157 114.265 1.00 52.81  ?  97  ILE B CG2 1 
ATOM   4166 C CD1 . ILE B 2 115 ? 153.223 129.680 116.047 1.00 52.81  ?  97  ILE B CD1 1 
ATOM   4167 N N   . LYS B 2 116 ? 152.102 134.723 113.539 1.00 53.17  ?  98  LYS B N   1 
ATOM   4168 C CA  . LYS B 2 116 ? 151.348 135.879 113.026 1.00 53.17  ?  98  LYS B CA  1 
ATOM   4169 C C   . LYS B 2 116 ? 149.868 135.556 112.817 1.00 53.17  ?  98  LYS B C   1 
ATOM   4170 O O   . LYS B 2 116 ? 149.274 135.875 111.788 1.00 53.17  ?  98  LYS B O   1 
ATOM   4171 C CB  . LYS B 2 116 ? 151.978 136.441 111.747 1.00 53.17  ?  98  LYS B CB  1 
ATOM   4172 C CG  . LYS B 2 116 ? 152.045 137.951 111.704 1.00 53.17  ?  98  LYS B CG  1 
ATOM   4173 C CD  . LYS B 2 116 ? 152.484 138.442 110.340 1.00 53.17  ?  98  LYS B CD  1 
ATOM   4174 C CE  . LYS B 2 116 ? 153.855 137.911 109.974 1.00 53.17  ?  98  LYS B CE  1 
ATOM   4175 N NZ  . LYS B 2 116 ? 154.288 138.403 108.640 1.00 53.17  1  98  LYS B NZ  1 
ATOM   4176 N N   . LYS B 2 117 ? 149.275 134.923 113.819 1.00 51.96  ?  99  LYS B N   1 
ATOM   4177 C CA  . LYS B 2 117 ? 147.850 134.644 113.859 1.00 51.96  ?  99  LYS B CA  1 
ATOM   4178 C C   . LYS B 2 117 ? 147.345 134.965 115.257 1.00 51.96  ?  99  LYS B C   1 
ATOM   4179 O O   . LYS B 2 117 ? 148.062 134.789 116.243 1.00 51.96  ?  99  LYS B O   1 
ATOM   4180 C CB  . LYS B 2 117 ? 147.561 133.181 113.498 1.00 51.96  ?  99  LYS B CB  1 
ATOM   4181 C CG  . LYS B 2 117 ? 146.117 132.894 113.142 1.00 51.96  ?  99  LYS B CG  1 
ATOM   4182 C CD  . LYS B 2 117 ? 145.791 131.415 113.254 1.00 51.96  ?  99  LYS B CD  1 
ATOM   4183 C CE  . LYS B 2 117 ? 146.275 130.649 112.038 1.00 51.96  ?  99  LYS B CE  1 
ATOM   4184 N NZ  . LYS B 2 117 ? 145.659 129.299 111.961 1.00 51.96  1  99  LYS B NZ  1 
ATOM   4185 N N   . SER B 2 118 ? 146.114 135.456 115.336 1.00 49.95  ?  100 SER B N   1 
ATOM   4186 C CA  . SER B 2 118 ? 145.545 135.840 116.617 1.00 49.95  ?  100 SER B CA  1 
ATOM   4187 C C   . SER B 2 118 ? 145.179 134.606 117.443 1.00 49.95  ?  100 SER B C   1 
ATOM   4188 O O   . SER B 2 118 ? 144.959 133.517 116.912 1.00 49.95  ?  100 SER B O   1 
ATOM   4189 C CB  . SER B 2 118 ? 144.317 136.720 116.402 1.00 49.95  ?  100 SER B CB  1 
ATOM   4190 O OG  . SER B 2 118 ? 144.571 137.726 115.442 1.00 49.95  ?  100 SER B OG  1 
ATOM   4191 N N   . GLY B 2 119 ? 145.122 134.786 118.763 1.00 49.15  ?  101 GLY B N   1 
ATOM   4192 C CA  . GLY B 2 119 ? 144.772 133.696 119.657 1.00 49.15  ?  101 GLY B CA  1 
ATOM   4193 C C   . GLY B 2 119 ? 145.702 133.522 120.843 1.00 49.15  ?  101 GLY B C   1 
ATOM   4194 O O   . GLY B 2 119 ? 145.270 133.082 121.913 1.00 49.15  ?  101 GLY B O   1 
ATOM   4195 N N   . ALA B 2 120 ? 146.993 133.772 120.611 1.00 49.28  ?  102 ALA B N   1 
ATOM   4196 C CA  . ALA B 2 120 ? 148.060 134.038 121.579 1.00 49.28  ?  102 ALA B CA  1 
ATOM   4197 C C   . ALA B 2 120 ? 148.572 132.861 122.403 1.00 49.28  ?  102 ALA B C   1 
ATOM   4198 O O   . ALA B 2 120 ? 149.634 132.973 123.019 1.00 49.28  ?  102 ALA B O   1 
ATOM   4199 C CB  . ALA B 2 120 ? 147.625 135.126 122.565 1.00 49.28  ?  102 ALA B CB  1 
ATOM   4200 N N   . SER B 2 121 ? 147.843 131.757 122.477 1.00 47.64  ?  103 SER B N   1 
ATOM   4201 C CA  . SER B 2 121 ? 148.466 130.475 122.782 1.00 47.64  ?  103 SER B CA  1 
ATOM   4202 C C   . SER B 2 121 ? 147.711 129.402 122.023 1.00 47.64  ?  103 SER B C   1 
ATOM   4203 O O   . SER B 2 121 ? 148.243 128.325 121.751 1.00 47.64  ?  103 SER B O   1 
ATOM   4204 C CB  . SER B 2 121 ? 148.496 130.189 124.283 1.00 47.64  ?  103 SER B CB  1 
ATOM   4205 O OG  . SER B 2 121 ? 147.276 130.524 124.894 1.00 47.64  ?  103 SER B OG  1 
ATOM   4206 N N   . TYR B 2 122 ? 146.456 129.710 121.693 1.00 45.41  ?  104 TYR B N   1 
ATOM   4207 C CA  . TYR B 2 122 ? 145.616 128.793 120.935 1.00 45.41  ?  104 TYR B CA  1 
ATOM   4208 C C   . TYR B 2 122 ? 146.180 128.567 119.538 1.00 45.41  ?  104 TYR B C   1 
ATOM   4209 O O   . TYR B 2 122 ? 146.297 127.421 119.083 1.00 45.41  ?  104 TYR B O   1 
ATOM   4210 C CB  . TYR B 2 122 ? 144.195 129.353 120.879 1.00 45.41  ?  104 TYR B CB  1 
ATOM   4211 C CG  . TYR B 2 122 ? 143.233 128.576 120.029 1.00 45.41  ?  104 TYR B CG  1 
ATOM   4212 C CD1 . TYR B 2 122 ? 142.666 127.400 120.493 1.00 45.41  ?  104 TYR B CD1 1 
ATOM   4213 C CD2 . TYR B 2 122 ? 142.871 129.028 118.768 1.00 45.41  ?  104 TYR B CD2 1 
ATOM   4214 C CE1 . TYR B 2 122 ? 141.782 126.686 119.721 1.00 45.41  ?  104 TYR B CE1 1 
ATOM   4215 C CE2 . TYR B 2 122 ? 141.988 128.319 117.989 1.00 45.41  ?  104 TYR B CE2 1 
ATOM   4216 C CZ  . TYR B 2 122 ? 141.446 127.149 118.472 1.00 45.41  ?  104 TYR B CZ  1 
ATOM   4217 O OH  . TYR B 2 122 ? 140.562 126.435 117.704 1.00 45.41  ?  104 TYR B OH  1 
ATOM   4218 N N   . ALA B 2 123 ? 146.579 129.648 118.866 1.00 46.23  ?  105 ALA B N   1 
ATOM   4219 C CA  . ALA B 2 123 ? 147.177 129.539 117.543 1.00 46.23  ?  105 ALA B CA  1 
ATOM   4220 C C   . ALA B 2 123 ? 148.548 128.882 117.596 1.00 46.23  ?  105 ALA B C   1 
ATOM   4221 O O   . ALA B 2 123 ? 148.916 128.142 116.678 1.00 46.23  ?  105 ALA B O   1 
ATOM   4222 C CB  . ALA B 2 123 ? 147.276 130.922 116.906 1.00 46.23  ?  105 ALA B CB  1 
ATOM   4223 N N   . TYR B 2 124 ? 149.292 129.089 118.679 1.00 45.87  ?  106 TYR B N   1 
ATOM   4224 C CA  . TYR B 2 124 ? 150.649 128.561 118.748 1.00 45.87  ?  106 TYR B CA  1 
ATOM   4225 C C   . TYR B 2 124 ? 150.637 127.068 119.064 1.00 45.87  ?  106 TYR B C   1 
ATOM   4226 O O   . TYR B 2 124 ? 151.435 126.304 118.507 1.00 45.87  ?  106 TYR B O   1 
ATOM   4227 C CB  . TYR B 2 124 ? 151.474 129.331 119.787 1.00 45.87  ?  106 TYR B CB  1 
ATOM   4228 C CG  . TYR B 2 124 ? 151.482 130.853 119.667 1.00 45.87  ?  106 TYR B CG  1 
ATOM   4229 C CD1 . TYR B 2 124 ? 151.285 131.496 118.448 1.00 45.87  ?  106 TYR B CD1 1 
ATOM   4230 C CD2 . TYR B 2 124 ? 151.711 131.647 120.782 1.00 45.87  ?  106 TYR B CD2 1 
ATOM   4231 C CE1 . TYR B 2 124 ? 151.286 132.867 118.351 1.00 45.87  ?  106 TYR B CE1 1 
ATOM   4232 C CE2 . TYR B 2 124 ? 151.728 133.026 120.686 1.00 45.87  ?  106 TYR B CE2 1 
ATOM   4233 C CZ  . TYR B 2 124 ? 151.508 133.626 119.472 1.00 45.87  ?  106 TYR B CZ  1 
ATOM   4234 O OH  . TYR B 2 124 ? 151.519 134.994 119.375 1.00 45.87  ?  106 TYR B OH  1 
ATOM   4235 N N   . ILE B 2 125 ? 149.719 126.636 119.930 1.00 45.15  ?  107 ILE B N   1 
ATOM   4236 C CA  . ILE B 2 125 ? 149.540 125.214 120.202 1.00 45.15  ?  107 ILE B CA  1 
ATOM   4237 C C   . ILE B 2 125 ? 148.919 124.512 118.994 1.00 45.15  ?  107 ILE B C   1 
ATOM   4238 O O   . ILE B 2 125 ? 149.238 123.348 118.716 1.00 45.15  ?  107 ILE B O   1 
ATOM   4239 C CB  . ILE B 2 125 ? 148.720 125.047 121.501 1.00 45.15  ?  107 ILE B CB  1 
ATOM   4240 C CG1 . ILE B 2 125 ? 149.554 125.495 122.700 1.00 45.15  ?  107 ILE B CG1 1 
ATOM   4241 C CG2 . ILE B 2 125 ? 148.285 123.620 121.747 1.00 45.15  ?  107 ILE B CG2 1 
ATOM   4242 C CD1 . ILE B 2 125 ? 148.739 125.841 123.919 1.00 45.15  ?  107 ILE B CD1 1 
ATOM   4243 N N   . LEU B 2 126 ? 148.067 125.210 118.230 1.00 47.06  ?  108 LEU B N   1 
ATOM   4244 C CA  . LEU B 2 126 ? 147.614 124.675 116.946 1.00 47.06  ?  108 LEU B CA  1 
ATOM   4245 C C   . LEU B 2 126 ? 148.762 124.492 115.964 1.00 47.06  ?  108 LEU B C   1 
ATOM   4246 O O   . LEU B 2 126 ? 148.799 123.507 115.220 1.00 47.06  ?  108 LEU B O   1 
ATOM   4247 C CB  . LEU B 2 126 ? 146.561 125.579 116.318 1.00 47.06  ?  108 LEU B CB  1 
ATOM   4248 C CG  . LEU B 2 126 ? 145.095 125.250 116.529 1.00 47.06  ?  108 LEU B CG  1 
ATOM   4249 C CD1 . LEU B 2 126 ? 144.291 126.380 115.991 1.00 47.06  ?  108 LEU B CD1 1 
ATOM   4250 C CD2 . LEU B 2 126 ? 144.748 123.970 115.809 1.00 47.06  ?  108 LEU B CD2 1 
ATOM   4251 N N   . GLU B 2 127 ? 149.696 125.437 115.928 1.00 51.70  ?  109 GLU B N   1 
ATOM   4252 C CA  . GLU B 2 127 ? 150.799 125.306 114.988 1.00 51.70  ?  109 GLU B CA  1 
ATOM   4253 C C   . GLU B 2 127 ? 151.802 124.251 115.437 1.00 51.70  ?  109 GLU B C   1 
ATOM   4254 O O   . GLU B 2 127 ? 152.495 123.668 114.599 1.00 51.70  ?  109 GLU B O   1 
ATOM   4255 C CB  . GLU B 2 127 ? 151.486 126.652 114.798 1.00 51.70  ?  109 GLU B CB  1 
ATOM   4256 C CG  . GLU B 2 127 ? 152.037 126.863 113.409 1.00 51.70  ?  109 GLU B CG  1 
ATOM   4257 C CD  . GLU B 2 127 ? 150.949 127.103 112.385 1.00 51.70  ?  109 GLU B CD  1 
ATOM   4258 O OE1 . GLU B 2 127 ? 149.883 127.637 112.758 1.00 51.70  ?  109 GLU B OE1 1 
ATOM   4259 O OE2 . GLU B 2 127 ? 151.156 126.755 111.204 1.00 51.70  -1 109 GLU B OE2 1 
ATOM   4260 N N   . ALA B 2 128 ? 151.886 123.980 116.740 1.00 50.41  ?  110 ALA B N   1 
ATOM   4261 C CA  . ALA B 2 128 ? 152.854 123.010 117.242 1.00 50.41  ?  110 ALA B CA  1 
ATOM   4262 C C   . ALA B 2 128 ? 152.262 121.608 117.396 1.00 50.41  ?  110 ALA B C   1 
ATOM   4263 O O   . ALA B 2 128 ? 152.741 120.659 116.769 1.00 50.41  ?  110 ALA B O   1 
ATOM   4264 C CB  . ALA B 2 128 ? 153.428 123.498 118.574 1.00 50.41  ?  110 ALA B CB  1 
ATOM   4265 N N   . PHE B 2 129 ? 151.230 121.461 118.225 1.00 50.11  ?  111 PHE B N   1 
ATOM   4266 C CA  . PHE B 2 129 ? 150.656 120.160 118.569 1.00 50.11  ?  111 PHE B CA  1 
ATOM   4267 C C   . PHE B 2 129 ? 149.159 120.148 118.305 1.00 50.11  ?  111 PHE B C   1 
ATOM   4268 O O   . PHE B 2 129 ? 148.367 119.734 119.154 1.00 50.11  ?  111 PHE B O   1 
ATOM   4269 C CB  . PHE B 2 129 ? 150.880 119.803 120.034 1.00 50.11  ?  111 PHE B CB  1 
ATOM   4270 C CG  . PHE B 2 129 ? 152.171 120.299 120.601 1.00 50.11  ?  111 PHE B CG  1 
ATOM   4271 C CD1 . PHE B 2 129 ? 153.380 119.797 120.155 1.00 50.11  ?  111 PHE B CD1 1 
ATOM   4272 C CD2 . PHE B 2 129 ? 152.173 121.254 121.602 1.00 50.11  ?  111 PHE B CD2 1 
ATOM   4273 C CE1 . PHE B 2 129 ? 154.566 120.250 120.687 1.00 50.11  ?  111 PHE B CE1 1 
ATOM   4274 C CE2 . PHE B 2 129 ? 153.354 121.709 122.136 1.00 50.11  ?  111 PHE B CE2 1 
ATOM   4275 C CZ  . PHE B 2 129 ? 154.551 121.203 121.681 1.00 50.11  ?  111 PHE B CZ  1 
ATOM   4276 N N   . GLY B 2 130 ? 148.760 120.586 117.111 1.00 52.69  ?  112 GLY B N   1 
ATOM   4277 C CA  . GLY B 2 130 ? 147.402 121.006 116.803 1.00 52.69  ?  112 GLY B CA  1 
ATOM   4278 C C   . GLY B 2 130 ? 146.234 120.085 117.076 1.00 52.69  ?  112 GLY B C   1 
ATOM   4279 O O   . GLY B 2 130 ? 146.402 118.868 117.166 1.00 52.69  ?  112 GLY B O   1 
ATOM   4280 N N   . GLY B 2 131 ? 145.039 120.658 117.200 1.00 52.79  ?  113 GLY B N   1 
ATOM   4281 C CA  . GLY B 2 131 ? 143.863 119.849 117.438 1.00 52.79  ?  113 GLY B CA  1 
ATOM   4282 C C   . GLY B 2 131 ? 143.462 119.725 118.891 1.00 52.79  ?  113 GLY B C   1 
ATOM   4283 O O   . GLY B 2 131 ? 142.696 120.543 119.407 1.00 52.79  ?  113 GLY B O   1 
ATOM   4284 N N   . PHE B 2 132 ? 143.956 118.664 119.530 1.00 52.30  ?  114 PHE B N   1 
ATOM   4285 C CA  . PHE B 2 132 ? 143.487 118.230 120.843 1.00 52.30  ?  114 PHE B CA  1 
ATOM   4286 C C   . PHE B 2 132 ? 143.781 119.261 121.933 1.00 52.30  ?  114 PHE B C   1 
ATOM   4287 O O   . PHE B 2 132 ? 142.869 119.733 122.630 1.00 52.30  ?  114 PHE B O   1 
ATOM   4288 C CB  . PHE B 2 132 ? 144.149 116.891 121.165 1.00 52.30  ?  114 PHE B CB  1 
ATOM   4289 C CG  . PHE B 2 132 ? 143.557 116.179 122.330 1.00 52.30  ?  114 PHE B CG  1 
ATOM   4290 C CD1 . PHE B 2 132 ? 142.283 115.655 122.255 1.00 52.30  ?  114 PHE B CD1 1 
ATOM   4291 C CD2 . PHE B 2 132 ? 144.285 116.010 123.495 1.00 52.30  ?  114 PHE B CD2 1 
ATOM   4292 C CE1 . PHE B 2 132 ? 141.738 114.988 123.324 1.00 52.30  ?  114 PHE B CE1 1 
ATOM   4293 C CE2 . PHE B 2 132 ? 143.743 115.341 124.570 1.00 52.30  ?  114 PHE B CE2 1 
ATOM   4294 C CZ  . PHE B 2 132 ? 142.467 114.834 124.486 1.00 52.30  ?  114 PHE B CZ  1 
ATOM   4295 N N   . LEU B 2 133 ? 145.058 119.613 122.101 1.00 49.66  ?  115 LEU B N   1 
ATOM   4296 C CA  . LEU B 2 133 ? 145.460 120.491 123.195 1.00 49.66  ?  115 LEU B CA  1 
ATOM   4297 C C   . LEU B 2 133 ? 144.962 121.917 122.996 1.00 49.66  ?  115 LEU B C   1 
ATOM   4298 O O   . LEU B 2 133 ? 144.646 122.608 123.976 1.00 49.66  ?  115 LEU B O   1 
ATOM   4299 C CB  . LEU B 2 133 ? 146.979 120.473 123.338 1.00 49.66  ?  115 LEU B CB  1 
ATOM   4300 C CG  . LEU B 2 133 ? 147.579 119.138 123.773 1.00 49.66  ?  115 LEU B CG  1 
ATOM   4301 C CD1 . LEU B 2 133 ? 149.071 119.122 123.529 1.00 49.66  ?  115 LEU B CD1 1 
ATOM   4302 C CD2 . LEU B 2 133 ? 147.276 118.888 125.234 1.00 49.66  ?  115 LEU B CD2 1 
ATOM   4303 N N   . ALA B 2 134 ? 144.863 122.358 121.741 1.00 47.80  ?  116 ALA B N   1 
ATOM   4304 C CA  . ALA B 2 134 ? 144.309 123.673 121.451 1.00 47.80  ?  116 ALA B CA  1 
ATOM   4305 C C   . ALA B 2 134 ? 142.833 123.739 121.812 1.00 47.80  ?  116 ALA B C   1 
ATOM   4306 O O   . ALA B 2 134 ? 142.365 124.752 122.344 1.00 47.80  ?  116 ALA B O   1 
ATOM   4307 C CB  . ALA B 2 134 ? 144.518 124.008 119.981 1.00 47.80  ?  116 ALA B CB  1 
ATOM   4308 N N   . PHE B 2 135 ? 142.096 122.653 121.567 1.00 48.83  ?  117 PHE B N   1 
ATOM   4309 C CA  . PHE B 2 135 ? 140.697 122.610 121.969 1.00 48.83  ?  117 PHE B CA  1 
ATOM   4310 C C   . PHE B 2 135 ? 140.553 122.577 123.483 1.00 48.83  ?  117 PHE B C   1 
ATOM   4311 O O   . PHE B 2 135 ? 139.612 123.162 124.024 1.00 48.83  ?  117 PHE B O   1 
ATOM   4312 C CB  . PHE B 2 135 ? 139.987 121.408 121.350 1.00 48.83  ?  117 PHE B CB  1 
ATOM   4313 C CG  . PHE B 2 135 ? 138.579 121.238 121.837 1.00 48.83  ?  117 PHE B CG  1 
ATOM   4314 C CD1 . PHE B 2 135 ? 137.582 122.096 121.410 1.00 48.83  ?  117 PHE B CD1 1 
ATOM   4315 C CD2 . PHE B 2 135 ? 138.257 120.247 122.750 1.00 48.83  ?  117 PHE B CD2 1 
ATOM   4316 C CE1 . PHE B 2 135 ? 136.291 121.959 121.872 1.00 48.83  ?  117 PHE B CE1 1 
ATOM   4317 C CE2 . PHE B 2 135 ? 136.971 120.112 123.214 1.00 48.83  ?  117 PHE B CE2 1 
ATOM   4318 C CZ  . PHE B 2 135 ? 135.987 120.965 122.773 1.00 48.83  ?  117 PHE B CZ  1 
ATOM   4319 N N   . ILE B 2 136 ? 141.468 121.897 124.182 1.00 48.87  ?  118 ILE B N   1 
ATOM   4320 C CA  . ILE B 2 136 ? 141.411 121.871 125.645 1.00 48.87  ?  118 ILE B CA  1 
ATOM   4321 C C   . ILE B 2 136 ? 141.656 123.264 126.224 1.00 48.87  ?  118 ILE B C   1 
ATOM   4322 O O   . ILE B 2 136 ? 140.950 123.703 127.146 1.00 48.87  ?  118 ILE B O   1 
ATOM   4323 C CB  . ILE B 2 136 ? 142.410 120.832 126.190 1.00 48.87  ?  118 ILE B CB  1 
ATOM   4324 C CG1 . ILE B 2 136 ? 141.935 119.423 125.850 1.00 48.87  ?  118 ILE B CG1 1 
ATOM   4325 C CG2 . ILE B 2 136 ? 142.586 120.959 127.694 1.00 48.87  ?  118 ILE B CG2 1 
ATOM   4326 C CD1 . ILE B 2 136 ? 142.843 118.342 126.361 1.00 48.87  ?  118 ILE B CD1 1 
ATOM   4327 N N   . ARG B 2 137 ? 142.618 123.999 125.654 1.00 47.76  ?  119 ARG B N   1 
ATOM   4328 C CA  . ARG B 2 137 ? 142.886 125.368 126.093 1.00 47.76  ?  119 ARG B CA  1 
ATOM   4329 C C   . ARG B 2 137 ? 141.710 126.298 125.800 1.00 47.76  ?  119 ARG B C   1 
ATOM   4330 O O   . ARG B 2 137 ? 141.325 127.115 126.652 1.00 47.76  ?  119 ARG B O   1 
ATOM   4331 C CB  . ARG B 2 137 ? 144.155 125.884 125.420 1.00 47.76  ?  119 ARG B CB  1 
ATOM   4332 C CG  . ARG B 2 137 ? 144.633 127.220 125.939 1.00 47.76  ?  119 ARG B CG  1 
ATOM   4333 C CD  . ARG B 2 137 ? 144.435 128.306 124.905 1.00 47.76  ?  119 ARG B CD  1 
ATOM   4334 N NE  . ARG B 2 137 ? 145.040 129.568 125.304 1.00 47.76  ?  119 ARG B NE  1 
ATOM   4335 C CZ  . ARG B 2 137 ? 144.460 130.462 126.094 1.00 47.76  ?  119 ARG B CZ  1 
ATOM   4336 N NH1 . ARG B 2 137 ? 143.255 130.238 126.579 1.00 47.76  1  119 ARG B NH1 1 
ATOM   4337 N NH2 . ARG B 2 137 ? 145.093 131.583 126.398 1.00 47.76  ?  119 ARG B NH2 1 
ATOM   4338 N N   . LEU B 2 138 ? 141.122 126.176 124.604 1.00 45.18  ?  120 LEU B N   1 
ATOM   4339 C CA  . LEU B 2 138 ? 139.972 127.000 124.247 1.00 45.18  ?  120 LEU B CA  1 
ATOM   4340 C C   . LEU B 2 138 ? 138.772 126.688 125.128 1.00 45.18  ?  120 LEU B C   1 
ATOM   4341 O O   . LEU B 2 138 ? 138.049 127.599 125.548 1.00 45.18  ?  120 LEU B O   1 
ATOM   4342 C CB  . LEU B 2 138 ? 139.619 126.787 122.778 1.00 45.18  ?  120 LEU B CB  1 
ATOM   4343 C CG  . LEU B 2 138 ? 138.563 127.714 122.185 1.00 45.18  ?  120 LEU B CG  1 
ATOM   4344 C CD1 . LEU B 2 138 ? 139.125 129.106 121.997 1.00 45.18  ?  120 LEU B CD1 1 
ATOM   4345 C CD2 . LEU B 2 138 ? 138.058 127.159 120.876 1.00 45.18  ?  120 LEU B CD2 1 
ATOM   4346 N N   . TRP B 2 139 ? 138.582 125.410 125.461 1.00 49.92  ?  121 TRP B N   1 
ATOM   4347 C CA  . TRP B 2 139 ? 137.463 124.997 126.297 1.00 49.92  ?  121 TRP B CA  1 
ATOM   4348 C C   . TRP B 2 139 ? 137.607 125.525 127.716 1.00 49.92  ?  121 TRP B C   1 
ATOM   4349 O O   . TRP B 2 139 ? 136.640 126.031 128.296 1.00 49.92  ?  121 TRP B O   1 
ATOM   4350 C CB  . TRP B 2 139 ? 137.354 123.474 126.298 1.00 49.92  ?  121 TRP B CB  1 
ATOM   4351 C CG  . TRP B 2 139 ? 136.296 122.952 127.205 1.00 49.92  ?  121 TRP B CG  1 
ATOM   4352 C CD1 . TRP B 2 139 ? 136.458 122.498 128.479 1.00 49.92  ?  121 TRP B CD1 1 
ATOM   4353 C CD2 . TRP B 2 139 ? 134.904 122.830 126.910 1.00 49.92  ?  121 TRP B CD2 1 
ATOM   4354 N NE1 . TRP B 2 139 ? 135.253 122.105 128.997 1.00 49.92  ?  121 TRP B NE1 1 
ATOM   4355 C CE2 . TRP B 2 139 ? 134.281 122.301 128.053 1.00 49.92  ?  121 TRP B CE2 1 
ATOM   4356 C CE3 . TRP B 2 139 ? 134.123 123.121 125.790 1.00 49.92  ?  121 TRP B CE3 1 
ATOM   4357 C CZ2 . TRP B 2 139 ? 132.917 122.049 128.106 1.00 49.92  ?  121 TRP B CZ2 1 
ATOM   4358 C CZ3 . TRP B 2 139 ? 132.770 122.874 125.846 1.00 49.92  ?  121 TRP B CZ3 1 
ATOM   4359 C CH2 . TRP B 2 139 ? 132.179 122.344 126.995 1.00 49.92  ?  121 TRP B CH2 1 
ATOM   4360 N N   . THR B 2 140 ? 138.811 125.443 128.288 1.00 49.26  ?  122 THR B N   1 
ATOM   4361 C CA  . THR B 2 140 ? 138.952 125.904 129.664 1.00 49.26  ?  122 THR B CA  1 
ATOM   4362 C C   . THR B 2 140 ? 138.929 127.428 129.761 1.00 49.26  ?  122 THR B C   1 
ATOM   4363 O O   . THR B 2 140 ? 138.430 127.962 130.759 1.00 49.26  ?  122 THR B O   1 
ATOM   4364 C CB  . THR B 2 140 ? 140.207 125.312 130.319 1.00 49.26  ?  122 THR B CB  1 
ATOM   4365 O OG1 . THR B 2 140 ? 140.226 125.656 131.708 1.00 49.26  ?  122 THR B OG1 1 
ATOM   4366 C CG2 . THR B 2 140 ? 141.463 125.815 129.683 1.00 49.26  ?  122 THR B CG2 1 
ATOM   4367 N N   . SER B 2 141 ? 139.366 128.147 128.719 1.00 47.73  ?  123 SER B N   1 
ATOM   4368 C CA  . SER B 2 141 ? 139.227 129.598 128.774 1.00 47.73  ?  123 SER B CA  1 
ATOM   4369 C C   . SER B 2 141 ? 137.798 130.041 128.506 1.00 47.73  ?  123 SER B C   1 
ATOM   4370 O O   . SER B 2 141 ? 137.377 131.089 129.003 1.00 47.73  ?  123 SER B O   1 
ATOM   4371 C CB  . SER B 2 141 ? 140.165 130.272 127.783 1.00 47.73  ?  123 SER B CB  1 
ATOM   4372 O OG  . SER B 2 141 ? 139.660 130.172 126.469 1.00 47.73  ?  123 SER B OG  1 
ATOM   4373 N N   . LEU B 2 142 ? 137.040 129.262 127.736 1.00 47.82  ?  124 LEU B N   1 
ATOM   4374 C CA  . LEU B 2 142 ? 135.624 129.555 127.568 1.00 47.82  ?  124 LEU B CA  1 
ATOM   4375 C C   . LEU B 2 142 ? 134.837 129.235 128.827 1.00 47.82  ?  124 LEU B C   1 
ATOM   4376 O O   . LEU B 2 142 ? 133.808 129.864 129.092 1.00 47.82  ?  124 LEU B O   1 
ATOM   4377 C CB  . LEU B 2 142 ? 135.071 128.762 126.387 1.00 47.82  ?  124 LEU B CB  1 
ATOM   4378 C CG  . LEU B 2 142 ? 133.701 129.125 125.824 1.00 47.82  ?  124 LEU B CG  1 
ATOM   4379 C CD1 . LEU B 2 142 ? 133.781 129.102 124.325 1.00 47.82  ?  124 LEU B CD1 1 
ATOM   4380 C CD2 . LEU B 2 142 ? 132.635 128.157 126.295 1.00 47.82  ?  124 LEU B CD2 1 
ATOM   4381 N N   . LEU B 2 143 ? 135.298 128.266 129.608 1.00 50.44  ?  125 LEU B N   1 
ATOM   4382 C CA  . LEU B 2 143 ? 134.471 127.753 130.686 1.00 50.44  ?  125 LEU B CA  1 
ATOM   4383 C C   . LEU B 2 143 ? 134.784 128.376 132.042 1.00 50.44  ?  125 LEU B C   1 
ATOM   4384 O O   . LEU B 2 143 ? 133.854 128.700 132.786 1.00 50.44  ?  125 LEU B O   1 
ATOM   4385 C CB  . LEU B 2 143 ? 134.612 126.232 130.753 1.00 50.44  ?  125 LEU B CB  1 
ATOM   4386 C CG  . LEU B 2 143 ? 133.653 125.480 131.666 1.00 50.44  ?  125 LEU B CG  1 
ATOM   4387 C CD1 . LEU B 2 143 ? 132.230 125.673 131.190 1.00 50.44  ?  125 LEU B CD1 1 
ATOM   4388 C CD2 . LEU B 2 143 ? 134.011 124.012 131.684 1.00 50.44  ?  125 LEU B CD2 1 
ATOM   4389 N N   . ILE B 2 144 ? 136.055 128.551 132.411 1.00 51.11  ?  126 ILE B N   1 
ATOM   4390 C CA  . ILE B 2 144 ? 136.332 128.975 133.780 1.00 51.11  ?  126 ILE B CA  1 
ATOM   4391 C C   . ILE B 2 144 ? 137.219 130.220 133.852 1.00 51.11  ?  126 ILE B C   1 
ATOM   4392 O O   . ILE B 2 144 ? 137.099 131.013 134.790 1.00 51.11  ?  126 ILE B O   1 
ATOM   4393 C CB  . ILE B 2 144 ? 136.924 127.794 134.588 1.00 51.11  ?  126 ILE B CB  1 
ATOM   4394 C CG1 . ILE B 2 144 ? 136.972 128.089 136.092 1.00 51.11  ?  126 ILE B CG1 1 
ATOM   4395 C CG2 . ILE B 2 144 ? 138.292 127.367 134.072 1.00 51.11  ?  126 ILE B CG2 1 
ATOM   4396 C CD1 . ILE B 2 144 ? 135.629 128.336 136.709 1.00 51.11  ?  126 ILE B CD1 1 
ATOM   4397 N N   . ILE B 2 145 ? 138.069 130.449 132.853 1.00 49.53  ?  127 ILE B N   1 
ATOM   4398 C CA  . ILE B 2 145 ? 139.149 131.421 133.028 1.00 49.53  ?  127 ILE B CA  1 
ATOM   4399 C C   . ILE B 2 145 ? 138.654 132.846 132.803 1.00 49.53  ?  127 ILE B C   1 
ATOM   4400 O O   . ILE B 2 145 ? 138.742 133.696 133.696 1.00 49.53  ?  127 ILE B O   1 
ATOM   4401 C CB  . ILE B 2 145 ? 140.339 131.080 132.115 1.00 49.53  ?  127 ILE B CB  1 
ATOM   4402 C CG1 . ILE B 2 145 ? 141.005 129.792 132.593 1.00 49.53  ?  127 ILE B CG1 1 
ATOM   4403 C CG2 . ILE B 2 145 ? 141.349 132.209 132.117 1.00 49.53  ?  127 ILE B CG2 1 
ATOM   4404 C CD1 . ILE B 2 145 ? 142.208 129.378 131.782 1.00 49.53  ?  127 ILE B CD1 1 
ATOM   4405 N N   . GLU B 2 146 ? 138.133 133.132 131.620 1.00 49.24  ?  128 GLU B N   1 
ATOM   4406 C CA  . GLU B 2 146 ? 137.769 134.504 131.272 1.00 49.24  ?  128 GLU B CA  1 
ATOM   4407 C C   . GLU B 2 146 ? 136.465 135.056 131.862 1.00 49.24  ?  128 GLU B C   1 
ATOM   4408 O O   . GLU B 2 146 ? 136.463 136.242 132.232 1.00 49.24  ?  128 GLU B O   1 
ATOM   4409 C CB  . GLU B 2 146 ? 137.762 134.653 129.751 1.00 49.24  ?  128 GLU B CB  1 
ATOM   4410 C CG  . GLU B 2 146 ? 139.140 134.940 129.219 1.00 49.24  ?  128 GLU B CG  1 
ATOM   4411 C CD  . GLU B 2 146 ? 139.436 134.206 127.946 1.00 49.24  ?  128 GLU B CD  1 
ATOM   4412 O OE1 . GLU B 2 146 ? 138.538 133.504 127.442 1.00 49.24  ?  128 GLU B OE1 1 
ATOM   4413 O OE2 . GLU B 2 146 ? 140.579 134.316 127.457 1.00 49.24  -1 128 GLU B OE2 1 
ATOM   4414 N N   . PRO B 2 147 ? 135.345 134.298 131.967 1.00 48.64  ?  129 PRO B N   1 
ATOM   4415 C CA  . PRO B 2 147 ? 134.174 134.867 132.664 1.00 48.64  ?  129 PRO B CA  1 
ATOM   4416 C C   . PRO B 2 147 ? 134.420 135.201 134.123 1.00 48.64  ?  129 PRO B C   1 
ATOM   4417 O O   . PRO B 2 147 ? 133.961 136.249 134.595 1.00 48.64  ?  129 PRO B O   1 
ATOM   4418 C CB  . PRO B 2 147 ? 133.113 133.769 132.522 1.00 48.64  ?  129 PRO B CB  1 
ATOM   4419 C CG  . PRO B 2 147 ? 133.485 133.049 131.336 1.00 48.64  ?  129 PRO B CG  1 
ATOM   4420 C CD  . PRO B 2 147 ? 134.965 133.014 131.337 1.00 48.64  ?  129 PRO B CD  1 
ATOM   4421 N N   . THR B 2 148 ? 135.172 134.358 134.834 1.00 48.39  ?  130 THR B N   1 
ATOM   4422 C CA  . THR B 2 148 ? 135.437 134.599 136.247 1.00 48.39  ?  130 THR B CA  1 
ATOM   4423 C C   . THR B 2 148 ? 136.329 135.818 136.444 1.00 48.39  ?  130 THR B C   1 
ATOM   4424 O O   . THR B 2 148 ? 136.062 136.649 137.319 1.00 48.39  ?  130 THR B O   1 
ATOM   4425 C CB  . THR B 2 148 ? 136.075 133.364 136.877 1.00 48.39  ?  130 THR B CB  1 
ATOM   4426 O OG1 . THR B 2 148 ? 135.306 132.206 136.539 1.00 48.39  ?  130 THR B OG1 1 
ATOM   4427 C CG2 . THR B 2 148 ? 136.110 133.494 138.379 1.00 48.39  ?  130 THR B CG2 1 
ATOM   4428 N N   . SER B 2 149 ? 137.365 135.961 135.614 1.00 46.03  ?  131 SER B N   1 
ATOM   4429 C CA  . SER B 2 149 ? 138.272 137.097 135.740 1.00 46.03  ?  131 SER B CA  1 
ATOM   4430 C C   . SER B 2 149 ? 137.586 138.404 135.364 1.00 46.03  ?  131 SER B C   1 
ATOM   4431 O O   . SER B 2 149 ? 137.790 139.430 136.029 1.00 46.03  ?  131 SER B O   1 
ATOM   4432 C CB  . SER B 2 149 ? 139.516 136.871 134.884 1.00 46.03  ?  131 SER B CB  1 
ATOM   4433 O OG  . SER B 2 149 ? 139.217 136.965 133.507 1.00 46.03  ?  131 SER B OG  1 
ATOM   4434 N N   . GLN B 2 150 ? 136.736 138.379 134.330 1.00 43.55  ?  132 GLN B N   1 
ATOM   4435 C CA  . GLN B 2 150 ? 136.013 139.588 133.946 1.00 43.55  ?  132 GLN B CA  1 
ATOM   4436 C C   . GLN B 2 150 ? 134.982 139.988 134.998 1.00 43.55  ?  132 GLN B C   1 
ATOM   4437 O O   . GLN B 2 150 ? 134.851 141.179 135.324 1.00 43.55  ?  132 GLN B O   1 
ATOM   4438 C CB  . GLN B 2 150 ? 135.355 139.386 132.586 1.00 43.55  ?  132 GLN B CB  1 
ATOM   4439 C CG  . GLN B 2 150 ? 136.326 139.515 131.433 1.00 43.55  ?  132 GLN B CG  1 
ATOM   4440 C CD  . GLN B 2 150 ? 135.772 138.972 130.142 1.00 43.55  ?  132 GLN B CD  1 
ATOM   4441 O OE1 . GLN B 2 150 ? 134.584 139.102 129.861 1.00 43.55  ?  132 GLN B OE1 1 
ATOM   4442 N NE2 . GLN B 2 150 ? 136.626 138.345 129.350 1.00 43.55  ?  132 GLN B NE2 1 
ATOM   4443 N N   . ALA B 2 151 ? 134.273 139.008 135.571 1.00 43.44  ?  133 ALA B N   1 
ATOM   4444 C CA  . ALA B 2 151 ? 133.311 139.300 136.628 1.00 43.44  ?  133 ALA B CA  1 
ATOM   4445 C C   . ALA B 2 151 ? 133.998 139.809 137.889 1.00 43.44  ?  133 ALA B C   1 
ATOM   4446 O O   . ALA B 2 151 ? 133.476 140.698 138.568 1.00 43.44  ?  133 ALA B O   1 
ATOM   4447 C CB  . ALA B 2 151 ? 132.481 138.056 136.935 1.00 43.44  ?  133 ALA B CB  1 
ATOM   4448 N N   . ILE B 2 152 ? 135.192 139.295 138.189 1.00 46.16  ?  134 ILE B N   1 
ATOM   4449 C CA  . ILE B 2 152 ? 135.912 139.728 139.382 1.00 46.16  ?  134 ILE B CA  1 
ATOM   4450 C C   . ILE B 2 152 ? 136.432 141.154 139.216 1.00 46.16  ?  134 ILE B C   1 
ATOM   4451 O O   . ILE B 2 152 ? 136.354 141.966 140.150 1.00 46.16  ?  134 ILE B O   1 
ATOM   4452 C CB  . ILE B 2 152 ? 137.028 138.713 139.698 1.00 46.16  ?  134 ILE B CB  1 
ATOM   4453 C CG1 . ILE B 2 152 ? 136.446 137.564 140.513 1.00 46.16  ?  134 ILE B CG1 1 
ATOM   4454 C CG2 . ILE B 2 152 ? 138.193 139.334 140.447 1.00 46.16  ?  134 ILE B CG2 1 
ATOM   4455 C CD1 . ILE B 2 152 ? 137.283 136.346 140.506 1.00 46.16  ?  134 ILE B CD1 1 
ATOM   4456 N N   . ILE B 2 153 ? 136.922 141.495 138.018 1.00 43.47  ?  135 ILE B N   1 
ATOM   4457 C CA  . ILE B 2 153 ? 137.362 142.865 137.745 1.00 43.47  ?  135 ILE B CA  1 
ATOM   4458 C C   . ILE B 2 153 ? 136.189 143.842 137.836 1.00 43.47  ?  135 ILE B C   1 
ATOM   4459 O O   . ILE B 2 153 ? 136.309 144.926 138.431 1.00 43.47  ?  135 ILE B O   1 
ATOM   4460 C CB  . ILE B 2 153 ? 138.061 142.926 136.373 1.00 43.47  ?  135 ILE B CB  1 
ATOM   4461 C CG1 . ILE B 2 153 ? 139.453 142.310 136.461 1.00 43.47  ?  135 ILE B CG1 1 
ATOM   4462 C CG2 . ILE B 2 153 ? 138.188 144.344 135.875 1.00 43.47  ?  135 ILE B CG2 1 
ATOM   4463 C CD1 . ILE B 2 153 ? 140.207 142.311 135.149 1.00 43.47  ?  135 ILE B CD1 1 
ATOM   4464 N N   . ALA B 2 154 ? 135.026 143.453 137.298 1.00 42.20  ?  136 ALA B N   1 
ATOM   4465 C CA  . ALA B 2 154 ? 133.843 144.309 137.377 1.00 42.20  ?  136 ALA B CA  1 
ATOM   4466 C C   . ALA B 2 154 ? 133.362 144.489 138.817 1.00 42.20  ?  136 ALA B C   1 
ATOM   4467 O O   . ALA B 2 154 ? 132.935 145.588 139.204 1.00 42.20  ?  136 ALA B O   1 
ATOM   4468 C CB  . ALA B 2 154 ? 132.731 143.732 136.505 1.00 42.20  ?  136 ALA B CB  1 
ATOM   4469 N N   . ILE B 2 155 ? 133.462 143.436 139.634 1.00 44.30  ?  137 ILE B N   1 
ATOM   4470 C CA  . ILE B 2 155 ? 133.030 143.526 141.025 1.00 44.30  ?  137 ILE B CA  1 
ATOM   4471 C C   . ILE B 2 155 ? 133.975 144.415 141.831 1.00 44.30  ?  137 ILE B C   1 
ATOM   4472 O O   . ILE B 2 155 ? 133.528 145.204 142.670 1.00 44.30  ?  137 ILE B O   1 
ATOM   4473 C CB  . ILE B 2 155 ? 132.885 142.111 141.623 1.00 44.30  ?  137 ILE B CB  1 
ATOM   4474 C CG1 . ILE B 2 155 ? 131.586 141.477 141.143 1.00 44.30  ?  137 ILE B CG1 1 
ATOM   4475 C CG2 . ILE B 2 155 ? 132.859 142.115 143.141 1.00 44.30  ?  137 ILE B CG2 1 
ATOM   4476 C CD1 . ILE B 2 155 ? 131.528 140.006 141.367 1.00 44.30  ?  137 ILE B CD1 1 
ATOM   4477 N N   . THR B 2 156 ? 135.284 144.356 141.553 1.00 45.15  ?  138 THR B N   1 
ATOM   4478 C CA  . THR B 2 156 ? 136.201 145.252 142.263 1.00 45.15  ?  138 THR B CA  1 
ATOM   4479 C C   . THR B 2 156 ? 136.031 146.706 141.834 1.00 45.15  ?  138 THR B C   1 
ATOM   4480 O O   . THR B 2 156 ? 136.184 147.613 142.666 1.00 45.15  ?  138 THR B O   1 
ATOM   4481 C CB  . THR B 2 156 ? 137.656 144.824 142.072 1.00 45.15  ?  138 THR B CB  1 
ATOM   4482 O OG1 . THR B 2 156 ? 137.981 144.829 140.680 1.00 45.15  ?  138 THR B OG1 1 
ATOM   4483 C CG2 . THR B 2 156 ? 137.894 143.445 142.648 1.00 45.15  ?  138 THR B CG2 1 
ATOM   4484 N N   . PHE B 2 157 ? 135.700 146.943 140.557 1.00 45.21  ?  139 PHE B N   1 
ATOM   4485 C CA  . PHE B 2 157 ? 135.350 148.290 140.104 1.00 45.21  ?  139 PHE B CA  1 
ATOM   4486 C C   . PHE B 2 157 ? 134.143 148.830 140.861 1.00 45.21  ?  139 PHE B C   1 
ATOM   4487 O O   . PHE B 2 157 ? 134.146 149.975 141.335 1.00 45.21  ?  139 PHE B O   1 
ATOM   4488 C CB  . PHE B 2 157 ? 135.075 148.279 138.598 1.00 45.21  ?  139 PHE B CB  1 
ATOM   4489 C CG  . PHE B 2 157 ? 134.218 149.425 138.118 1.00 45.21  ?  139 PHE B CG  1 
ATOM   4490 C CD1 . PHE B 2 157 ? 134.755 150.690 137.973 1.00 45.21  ?  139 PHE B CD1 1 
ATOM   4491 C CD2 . PHE B 2 157 ? 132.881 149.231 137.796 1.00 45.21  ?  139 PHE B CD2 1 
ATOM   4492 C CE1 . PHE B 2 157 ? 133.980 151.741 137.529 1.00 45.21  ?  139 PHE B CE1 1 
ATOM   4493 C CE2 . PHE B 2 157 ? 132.101 150.281 137.360 1.00 45.21  ?  139 PHE B CE2 1 
ATOM   4494 C CZ  . PHE B 2 157 ? 132.654 151.536 137.224 1.00 45.21  ?  139 PHE B CZ  1 
ATOM   4495 N N   . ALA B 2 158 ? 133.098 148.006 140.983 1.00 47.25  ?  140 ALA B N   1 
ATOM   4496 C CA  . ALA B 2 158 ? 131.898 148.431 141.694 1.00 47.25  ?  140 ALA B CA  1 
ATOM   4497 C C   . ALA B 2 158 ? 132.148 148.609 143.186 1.00 47.25  ?  140 ALA B C   1 
ATOM   4498 O O   . ALA B 2 158 ? 131.528 149.470 143.816 1.00 47.25  ?  140 ALA B O   1 
ATOM   4499 C CB  . ALA B 2 158 ? 130.779 147.424 141.467 1.00 47.25  ?  140 ALA B CB  1 
ATOM   4500 N N   . ASN B 2 159 ? 133.050 147.814 143.763 1.00 48.44  ?  141 ASN B N   1 
ATOM   4501 C CA  . ASN B 2 159 ? 133.345 147.937 145.184 1.00 48.44  ?  141 ASN B CA  1 
ATOM   4502 C C   . ASN B 2 159 ? 134.148 149.189 145.487 1.00 48.44  ?  141 ASN B C   1 
ATOM   4503 O O   . ASN B 2 159 ? 133.974 149.787 146.553 1.00 48.44  ?  141 ASN B O   1 
ATOM   4504 C CB  . ASN B 2 159 ? 134.101 146.707 145.677 1.00 48.44  ?  141 ASN B CB  1 
ATOM   4505 C CG  . ASN B 2 159 ? 133.196 145.526 145.914 1.00 48.44  ?  141 ASN B CG  1 
ATOM   4506 O OD1 . ASN B 2 159 ? 131.986 145.674 146.051 1.00 48.44  ?  141 ASN B OD1 1 
ATOM   4507 N ND2 . ASN B 2 159 ? 133.780 144.339 145.971 1.00 48.44  ?  141 ASN B ND2 1 
ATOM   4508 N N   . TYR B 2 160 ? 135.032 149.602 144.583 1.00 50.66  ?  142 TYR B N   1 
ATOM   4509 C CA  . TYR B 2 160 ? 135.814 150.797 144.856 1.00 50.66  ?  142 TYR B CA  1 
ATOM   4510 C C   . TYR B 2 160 ? 135.190 152.069 144.305 1.00 50.66  ?  142 TYR B C   1 
ATOM   4511 O O   . TYR B 2 160 ? 135.712 153.155 144.571 1.00 50.66  ?  142 TYR B O   1 
ATOM   4512 C CB  . TYR B 2 160 ? 137.235 150.628 144.329 1.00 50.66  ?  142 TYR B CB  1 
ATOM   4513 C CG  . TYR B 2 160 ? 138.065 149.811 145.277 1.00 50.66  ?  142 TYR B CG  1 
ATOM   4514 C CD1 . TYR B 2 160 ? 138.712 150.407 146.348 1.00 50.66  ?  142 TYR B CD1 1 
ATOM   4515 C CD2 . TYR B 2 160 ? 138.164 148.436 145.131 1.00 50.66  ?  142 TYR B CD2 1 
ATOM   4516 C CE1 . TYR B 2 160 ? 139.455 149.661 147.231 1.00 50.66  ?  142 TYR B CE1 1 
ATOM   4517 C CE2 . TYR B 2 160 ? 138.905 147.682 146.009 1.00 50.66  ?  142 TYR B CE2 1 
ATOM   4518 C CZ  . TYR B 2 160 ? 139.548 148.300 147.056 1.00 50.66  ?  142 TYR B CZ  1 
ATOM   4519 O OH  . TYR B 2 160 ? 140.289 147.552 147.936 1.00 50.66  ?  142 TYR B OH  1 
ATOM   4520 N N   . MET B 2 161 ? 134.091 151.975 143.555 1.00 54.49  ?  143 MET B N   1 
ATOM   4521 C CA  . MET B 2 161 ? 133.349 153.189 143.233 1.00 54.49  ?  143 MET B CA  1 
ATOM   4522 C C   . MET B 2 161 ? 132.613 153.743 144.447 1.00 54.49  ?  143 MET B C   1 
ATOM   4523 O O   . MET B 2 161 ? 132.490 154.964 144.587 1.00 54.49  ?  143 MET B O   1 
ATOM   4524 C CB  . MET B 2 161 ? 132.357 152.929 142.102 1.00 54.49  ?  143 MET B CB  1 
ATOM   4525 C CG  . MET B 2 161 ? 132.937 153.102 140.716 1.00 54.49  ?  143 MET B CG  1 
ATOM   4526 S SD  . MET B 2 161 ? 133.492 154.779 140.373 1.00 54.49  ?  143 MET B SD  1 
ATOM   4527 C CE  . MET B 2 161 ? 131.927 155.634 140.279 1.00 54.49  ?  143 MET B CE  1 
ATOM   4528 N N   . VAL B 2 162 ? 132.122 152.874 145.329 1.00 55.05  ?  144 VAL B N   1 
ATOM   4529 C CA  . VAL B 2 162 ? 131.273 153.273 146.444 1.00 55.05  ?  144 VAL B CA  1 
ATOM   4530 C C   . VAL B 2 162 ? 132.025 153.270 147.767 1.00 55.05  ?  144 VAL B C   1 
ATOM   4531 O O   . VAL B 2 162 ? 131.400 153.335 148.829 1.00 55.05  ?  144 VAL B O   1 
ATOM   4532 C CB  . VAL B 2 162 ? 130.019 152.389 146.531 1.00 55.05  ?  144 VAL B CB  1 
ATOM   4533 C CG1 . VAL B 2 162 ? 129.194 152.531 145.278 1.00 55.05  ?  144 VAL B CG1 1 
ATOM   4534 C CG2 . VAL B 2 162 ? 130.407 150.942 146.745 1.00 55.05  ?  144 VAL B CG2 1 
ATOM   4535 N N   . GLN B 2 163 ? 133.347 153.204 147.735 1.00 58.39  ?  145 GLN B N   1 
ATOM   4536 C CA  . GLN B 2 163 ? 134.147 153.159 148.954 1.00 58.39  ?  145 GLN B CA  1 
ATOM   4537 C C   . GLN B 2 163 ? 134.218 154.473 149.746 1.00 58.39  ?  145 GLN B C   1 
ATOM   4538 O O   . GLN B 2 163 ? 134.246 154.397 150.980 1.00 58.39  ?  145 GLN B O   1 
ATOM   4539 C CB  . GLN B 2 163 ? 135.561 152.662 148.635 1.00 58.39  ?  145 GLN B CB  1 
ATOM   4540 C CG  . GLN B 2 163 ? 136.283 152.045 149.817 1.00 58.39  ?  145 GLN B CG  1 
ATOM   4541 C CD  . GLN B 2 163 ? 137.133 153.046 150.573 1.00 58.39  ?  145 GLN B CD  1 
ATOM   4542 O OE1 . GLN B 2 163 ? 137.327 154.174 150.128 1.00 58.39  ?  145 GLN B OE1 1 
ATOM   4543 N NE2 . GLN B 2 163 ? 137.644 152.635 151.724 1.00 58.39  ?  145 GLN B NE2 1 
ATOM   4544 N N   . PRO B 2 164 ? 134.276 155.680 149.149 1.00 58.85  ?  146 PRO B N   1 
ATOM   4545 C CA  . PRO B 2 164 ? 134.184 156.882 149.998 1.00 58.85  ?  146 PRO B CA  1 
ATOM   4546 C C   . PRO B 2 164 ? 132.823 157.096 150.638 1.00 58.85  ?  146 PRO B C   1 
ATOM   4547 O O   . PRO B 2 164 ? 132.730 157.874 151.593 1.00 58.85  ?  146 PRO B O   1 
ATOM   4548 C CB  . PRO B 2 164 ? 134.530 158.028 149.036 1.00 58.85  ?  146 PRO B CB  1 
ATOM   4549 C CG  . PRO B 2 164 ? 134.335 157.475 147.700 1.00 58.85  ?  146 PRO B CG  1 
ATOM   4550 C CD  . PRO B 2 164 ? 134.778 156.070 147.817 1.00 58.85  ?  146 PRO B CD  1 
ATOM   4551 N N   . LEU B 2 165 ? 131.768 156.444 150.152 1.00 60.76  ?  147 LEU B N   1 
ATOM   4552 C CA  . LEU B 2 165 ? 130.489 156.496 150.846 1.00 60.76  ?  147 LEU B CA  1 
ATOM   4553 C C   . LEU B 2 165 ? 130.422 155.481 151.976 1.00 60.76  ?  147 LEU B C   1 
ATOM   4554 O O   . LEU B 2 165 ? 129.679 155.680 152.941 1.00 60.76  ?  147 LEU B O   1 
ATOM   4555 C CB  . LEU B 2 165 ? 129.344 156.254 149.865 1.00 60.76  ?  147 LEU B CB  1 
ATOM   4556 C CG  . LEU B 2 165 ? 129.083 157.336 148.820 1.00 60.76  ?  147 LEU B CG  1 
ATOM   4557 C CD1 . LEU B 2 165 ? 128.230 156.782 147.696 1.00 60.76  ?  147 LEU B CD1 1 
ATOM   4558 C CD2 . LEU B 2 165 ? 128.409 158.533 149.456 1.00 60.76  ?  147 LEU B CD2 1 
ATOM   4559 N N   . PHE B 2 166 ? 131.188 154.400 151.876 1.00 63.13  ?  148 PHE B N   1 
ATOM   4560 C CA  . PHE B 2 166 ? 131.199 153.327 152.867 1.00 63.13  ?  148 PHE B CA  1 
ATOM   4561 C C   . PHE B 2 166 ? 132.640 153.053 153.276 1.00 63.13  ?  148 PHE B C   1 
ATOM   4562 O O   . PHE B 2 166 ? 133.236 152.065 152.830 1.00 63.13  ?  148 PHE B O   1 
ATOM   4563 C CB  . PHE B 2 166 ? 130.547 152.066 152.302 1.00 63.13  ?  148 PHE B CB  1 
ATOM   4564 C CG  . PHE B 2 166 ? 129.090 152.214 152.010 1.00 63.13  ?  148 PHE B CG  1 
ATOM   4565 C CD1 . PHE B 2 166 ? 128.156 152.142 153.027 1.00 63.13  ?  148 PHE B CD1 1 
ATOM   4566 C CD2 . PHE B 2 166 ? 128.652 152.422 150.716 1.00 63.13  ?  148 PHE B CD2 1 
ATOM   4567 C CE1 . PHE B 2 166 ? 126.811 152.276 152.755 1.00 63.13  ?  148 PHE B CE1 1 
ATOM   4568 C CE2 . PHE B 2 166 ? 127.312 152.559 150.439 1.00 63.13  ?  148 PHE B CE2 1 
ATOM   4569 C CZ  . PHE B 2 166 ? 126.390 152.486 151.459 1.00 63.13  ?  148 PHE B CZ  1 
ATOM   4570 N N   . PRO B 2 167 ? 133.241 153.921 154.124 1.00 67.00  ?  149 PRO B N   1 
ATOM   4571 C CA  . PRO B 2 167 ? 134.689 153.829 154.384 1.00 67.00  ?  149 PRO B CA  1 
ATOM   4572 C C   . PRO B 2 167 ? 135.135 152.574 155.124 1.00 67.00  ?  149 PRO B C   1 
ATOM   4573 O O   . PRO B 2 167 ? 136.024 151.864 154.647 1.00 67.00  ?  149 PRO B O   1 
ATOM   4574 C CB  . PRO B 2 167 ? 134.978 155.090 155.208 1.00 67.00  ?  149 PRO B CB  1 
ATOM   4575 C CG  . PRO B 2 167 ? 133.678 155.512 155.755 1.00 67.00  ?  149 PRO B CG  1 
ATOM   4576 C CD  . PRO B 2 167 ? 132.630 155.080 154.795 1.00 67.00  ?  149 PRO B CD  1 
ATOM   4577 N N   . SER B 2 168 ? 134.552 152.289 156.284 1.00 74.20  ?  150 SER B N   1 
ATOM   4578 C CA  . SER B 2 168 ? 134.732 151.005 156.967 1.00 74.20  ?  150 SER B CA  1 
ATOM   4579 C C   . SER B 2 168 ? 133.336 150.535 157.347 1.00 74.20  ?  150 SER B C   1 
ATOM   4580 O O   . SER B 2 168 ? 132.902 150.707 158.487 1.00 74.20  ?  150 SER B O   1 
ATOM   4581 C CB  . SER B 2 168 ? 135.631 151.159 158.173 1.00 74.20  ?  150 SER B CB  1 
ATOM   4582 O OG  . SER B 2 168 ? 135.024 152.012 159.127 1.00 74.20  ?  150 SER B OG  1 
ATOM   4583 N N   . CYS B 2 169 ? 132.631 149.936 156.391 1.00 79.22  ?  151 CYS B N   1 
ATOM   4584 C CA  . CYS B 2 169 ? 131.186 149.895 156.546 1.00 79.22  ?  151 CYS B CA  1 
ATOM   4585 C C   . CYS B 2 169 ? 130.525 148.595 156.112 1.00 79.22  ?  151 CYS B C   1 
ATOM   4586 O O   . CYS B 2 169 ? 129.363 148.366 156.466 1.00 79.22  ?  151 CYS B O   1 
ATOM   4587 C CB  . CYS B 2 169 ? 130.590 151.051 155.758 1.00 79.22  ?  151 CYS B CB  1 
ATOM   4588 S SG  . CYS B 2 169 ? 129.193 151.855 156.486 1.00 79.22  ?  151 CYS B SG  1 
ATOM   4589 N N   . PHE B 2 170 ? 131.246 147.761 155.349 1.00 78.44  ?  152 PHE B N   1 
ATOM   4590 C CA  . PHE B 2 170 ? 130.718 146.558 154.686 1.00 78.44  ?  152 PHE B CA  1 
ATOM   4591 C C   . PHE B 2 170 ? 129.553 146.906 153.749 1.00 78.44  ?  152 PHE B C   1 
ATOM   4592 O O   . PHE B 2 170 ? 128.387 146.616 154.023 1.00 78.44  ?  152 PHE B O   1 
ATOM   4593 C CB  . PHE B 2 170 ? 130.317 145.467 155.691 1.00 78.44  ?  152 PHE B CB  1 
ATOM   4594 C CG  . PHE B 2 170 ? 131.414 144.498 156.000 1.00 78.44  ?  152 PHE B CG  1 
ATOM   4595 C CD1 . PHE B 2 170 ? 131.598 143.375 155.214 1.00 78.44  ?  152 PHE B CD1 1 
ATOM   4596 C CD2 . PHE B 2 170 ? 132.258 144.707 157.078 1.00 78.44  ?  152 PHE B CD2 1 
ATOM   4597 C CE1 . PHE B 2 170 ? 132.606 142.475 155.493 1.00 78.44  ?  152 PHE B CE1 1 
ATOM   4598 C CE2 . PHE B 2 170 ? 133.271 143.811 157.364 1.00 78.44  ?  152 PHE B CE2 1 
ATOM   4599 C CZ  . PHE B 2 170 ? 133.444 142.693 156.570 1.00 78.44  ?  152 PHE B CZ  1 
ATOM   4600 N N   . ALA B 2 171 ? 129.917 147.589 152.647 1.00 68.05  ?  153 ALA B N   1 
ATOM   4601 C CA  . ALA B 2 171 ? 129.089 148.061 151.530 1.00 68.05  ?  153 ALA B CA  1 
ATOM   4602 C C   . ALA B 2 171 ? 128.063 147.036 151.044 1.00 68.05  ?  153 ALA B C   1 
ATOM   4603 O O   . ALA B 2 171 ? 128.336 145.830 151.094 1.00 68.05  ?  153 ALA B O   1 
ATOM   4604 C CB  . ALA B 2 171 ? 130.003 148.466 150.369 1.00 68.05  ?  153 ALA B CB  1 
ATOM   4605 N N   . PRO B 2 172 ? 126.882 147.467 150.578 1.00 62.11  ?  154 PRO B N   1 
ATOM   4606 C CA  . PRO B 2 172 ? 125.804 146.510 150.285 1.00 62.11  ?  154 PRO B CA  1 
ATOM   4607 C C   . PRO B 2 172 ? 126.086 145.619 149.085 1.00 62.11  ?  154 PRO B C   1 
ATOM   4608 O O   . PRO B 2 172 ? 126.690 146.031 148.093 1.00 62.11  ?  154 PRO B O   1 
ATOM   4609 C CB  . PRO B 2 172 ? 124.589 147.408 150.026 1.00 62.11  ?  154 PRO B CB  1 
ATOM   4610 C CG  . PRO B 2 172 ? 125.143 148.732 149.713 1.00 62.11  ?  154 PRO B CG  1 
ATOM   4611 C CD  . PRO B 2 172 ? 126.400 148.857 150.497 1.00 62.11  ?  154 PRO B CD  1 
ATOM   4612 N N   . TYR B 2 173 ? 125.612 144.376 149.194 1.00 58.30  ?  155 TYR B N   1 
ATOM   4613 C CA  . TYR B 2 173 ? 125.973 143.314 148.263 1.00 58.30  ?  155 TYR B CA  1 
ATOM   4614 C C   . TYR B 2 173 ? 125.301 143.492 146.908 1.00 58.30  ?  155 TYR B C   1 
ATOM   4615 O O   . TYR B 2 173 ? 125.959 143.403 145.867 1.00 58.30  ?  155 TYR B O   1 
ATOM   4616 C CB  . TYR B 2 173 ? 125.606 141.959 148.873 1.00 58.30  ?  155 TYR B CB  1 
ATOM   4617 C CG  . TYR B 2 173 ? 125.777 140.777 147.949 1.00 58.30  ?  155 TYR B CG  1 
ATOM   4618 C CD1 . TYR B 2 173 ? 127.029 140.218 147.732 1.00 58.30  ?  155 TYR B CD1 1 
ATOM   4619 C CD2 . TYR B 2 173 ? 124.683 140.203 147.315 1.00 58.30  ?  155 TYR B CD2 1 
ATOM   4620 C CE1 . TYR B 2 173 ? 127.186 139.134 146.895 1.00 58.30  ?  155 TYR B CE1 1 
ATOM   4621 C CE2 . TYR B 2 173 ? 124.833 139.122 146.475 1.00 58.30  ?  155 TYR B CE2 1 
ATOM   4622 C CZ  . TYR B 2 173 ? 126.086 138.593 146.272 1.00 58.30  ?  155 TYR B CZ  1 
ATOM   4623 O OH  . TYR B 2 173 ? 126.233 137.514 145.438 1.00 58.30  ?  155 TYR B OH  1 
ATOM   4624 N N   . ALA B 2 174 ? 123.990 143.735 146.904 1.00 56.78  ?  156 ALA B N   1 
ATOM   4625 C CA  . ALA B 2 174 ? 123.240 143.781 145.656 1.00 56.78  ?  156 ALA B CA  1 
ATOM   4626 C C   . ALA B 2 174 ? 123.529 145.030 144.839 1.00 56.78  ?  156 ALA B C   1 
ATOM   4627 O O   . ALA B 2 174 ? 123.260 145.039 143.636 1.00 56.78  ?  156 ALA B O   1 
ATOM   4628 C CB  . ALA B 2 174 ? 121.744 143.687 145.939 1.00 56.78  ?  156 ALA B CB  1 
ATOM   4629 N N   . ALA B 2 175 ? 124.065 146.080 145.457 1.00 56.13  ?  157 ALA B N   1 
ATOM   4630 C CA  . ALA B 2 175 ? 124.410 147.284 144.715 1.00 56.13  ?  157 ALA B CA  1 
ATOM   4631 C C   . ALA B 2 175 ? 125.699 147.138 143.924 1.00 56.13  ?  157 ALA B C   1 
ATOM   4632 O O   . ALA B 2 175 ? 125.913 147.894 142.973 1.00 56.13  ?  157 ALA B O   1 
ATOM   4633 C CB  . ALA B 2 175 ? 124.532 148.472 145.665 1.00 56.13  ?  157 ALA B CB  1 
ATOM   4634 N N   . SER B 2 176 ? 126.564 146.199 144.295 1.00 54.81  ?  158 SER B N   1 
ATOM   4635 C CA  . SER B 2 176 ? 127.808 146.005 143.564 1.00 54.81  ?  158 SER B CA  1 
ATOM   4636 C C   . SER B 2 176 ? 127.624 145.102 142.352 1.00 54.81  ?  158 SER B C   1 
ATOM   4637 O O   . SER B 2 176 ? 128.275 145.308 141.321 1.00 54.81  ?  158 SER B O   1 
ATOM   4638 C CB  . SER B 2 176 ? 128.878 145.434 144.495 1.00 54.81  ?  158 SER B CB  1 
ATOM   4639 O OG  . SER B 2 176 ? 128.563 144.108 144.876 1.00 54.81  ?  158 SER B OG  1 
ATOM   4640 N N   . ARG B 2 177 ? 126.732 144.115 142.448 1.00 51.37  ?  159 ARG B N   1 
ATOM   4641 C CA  . ARG B 2 177 ? 126.460 143.249 141.308 1.00 51.37  ?  159 ARG B CA  1 
ATOM   4642 C C   . ARG B 2 177 ? 125.751 143.997 140.189 1.00 51.37  ?  159 ARG B C   1 
ATOM   4643 O O   . ARG B 2 177 ? 126.026 143.749 139.010 1.00 51.37  ?  159 ARG B O   1 
ATOM   4644 C CB  . ARG B 2 177 ? 125.632 142.049 141.756 1.00 51.37  ?  159 ARG B CB  1 
ATOM   4645 C CG  . ARG B 2 177 ? 126.264 141.272 142.885 1.00 51.37  ?  159 ARG B CG  1 
ATOM   4646 C CD  . ARG B 2 177 ? 127.426 140.444 142.381 1.00 51.37  ?  159 ARG B CD  1 
ATOM   4647 N NE  . ARG B 2 177 ? 128.374 140.122 143.438 1.00 51.37  ?  159 ARG B NE  1 
ATOM   4648 C CZ  . ARG B 2 177 ? 128.940 138.931 143.586 1.00 51.37  ?  159 ARG B CZ  1 
ATOM   4649 N NH1 . ARG B 2 177 ? 128.645 137.951 142.747 1.00 51.37  1  159 ARG B NH1 1 
ATOM   4650 N NH2 . ARG B 2 177 ? 129.796 138.717 144.572 1.00 51.37  ?  159 ARG B NH2 1 
ATOM   4651 N N   . LEU B 2 178 ? 124.873 144.939 140.537 1.00 51.29  ?  160 LEU B N   1 
ATOM   4652 C CA  . LEU B 2 178 ? 124.172 145.723 139.527 1.00 51.29  ?  160 LEU B CA  1 
ATOM   4653 C C   . LEU B 2 178 ? 125.117 146.671 138.803 1.00 51.29  ?  160 LEU B C   1 
ATOM   4654 O O   . LEU B 2 178 ? 125.044 146.813 137.576 1.00 51.29  ?  160 LEU B O   1 
ATOM   4655 C CB  . LEU B 2 178 ? 123.031 146.501 140.177 1.00 51.29  ?  160 LEU B CB  1 
ATOM   4656 C CG  . LEU B 2 178 ? 121.847 145.667 140.656 1.00 51.29  ?  160 LEU B CG  1 
ATOM   4657 C CD1 . LEU B 2 178 ? 120.812 146.556 141.309 1.00 51.29  ?  160 LEU B CD1 1 
ATOM   4658 C CD2 . LEU B 2 178 ? 121.243 144.897 139.505 1.00 51.29  ?  160 LEU B CD2 1 
ATOM   4659 N N   . LEU B 2 179 ? 126.023 147.315 139.544 1.00 49.75  ?  161 LEU B N   1 
ATOM   4660 C CA  . LEU B 2 179 ? 127.016 148.184 138.925 1.00 49.75  ?  161 LEU B CA  1 
ATOM   4661 C C   . LEU B 2 179 ? 128.007 147.395 138.081 1.00 49.75  ?  161 LEU B C   1 
ATOM   4662 O O   . LEU B 2 179 ? 128.440 147.876 137.028 1.00 49.75  ?  161 LEU B O   1 
ATOM   4663 C CB  . LEU B 2 179 ? 127.751 148.983 139.996 1.00 49.75  ?  161 LEU B CB  1 
ATOM   4664 C CG  . LEU B 2 179 ? 127.196 150.357 140.352 1.00 49.75  ?  161 LEU B CG  1 
ATOM   4665 C CD1 . LEU B 2 179 ? 128.023 150.973 141.458 1.00 49.75  ?  161 LEU B CD1 1 
ATOM   4666 C CD2 . LEU B 2 179 ? 127.191 151.251 139.136 1.00 49.75  ?  161 LEU B CD2 1 
ATOM   4667 N N   . ALA B 2 180 ? 128.346 146.176 138.510 1.00 47.07  ?  162 ALA B N   1 
ATOM   4668 C CA  . ALA B 2 180 ? 129.212 145.311 137.714 1.00 47.07  ?  162 ALA B CA  1 
ATOM   4669 C C   . ALA B 2 180 ? 128.541 144.894 136.409 1.00 47.07  ?  162 ALA B C   1 
ATOM   4670 O O   . ALA B 2 180 ? 129.184 144.879 135.349 1.00 47.07  ?  162 ALA B O   1 
ATOM   4671 C CB  . ALA B 2 180 ? 129.601 144.084 138.532 1.00 47.07  ?  162 ALA B CB  1 
ATOM   4672 N N   . ALA B 2 181 ? 127.245 144.571 136.468 1.00 47.37  ?  163 ALA B N   1 
ATOM   4673 C CA  . ALA B 2 181 ? 126.504 144.207 135.265 1.00 47.37  ?  163 ALA B CA  1 
ATOM   4674 C C   . ALA B 2 181 ? 126.373 145.387 134.311 1.00 47.37  ?  163 ALA B C   1 
ATOM   4675 O O   . ALA B 2 181 ? 126.503 145.220 133.091 1.00 47.37  ?  163 ALA B O   1 
ATOM   4676 C CB  . ALA B 2 181 ? 125.127 143.668 135.645 1.00 47.37  ?  163 ALA B CB  1 
ATOM   4677 N N   . ALA B 2 182 ? 126.146 146.588 134.852 1.00 48.85  ?  164 ALA B N   1 
ATOM   4678 C CA  . ALA B 2 182 ? 126.075 147.784 134.018 1.00 48.85  ?  164 ALA B CA  1 
ATOM   4679 C C   . ALA B 2 182 ? 127.415 148.088 133.358 1.00 48.85  ?  164 ALA B C   1 
ATOM   4680 O O   . ALA B 2 182 ? 127.459 148.483 132.186 1.00 48.85  ?  164 ALA B O   1 
ATOM   4681 C CB  . ALA B 2 182 ? 125.609 148.975 134.852 1.00 48.85  ?  164 ALA B CB  1 
ATOM   4682 N N   . CYS B 2 183 ? 128.514 147.882 134.090 1.00 48.11  ?  165 CYS B N   1 
ATOM   4683 C CA  . CYS B 2 183 ? 129.851 148.099 133.544 1.00 48.11  ?  165 CYS B CA  1 
ATOM   4684 C C   . CYS B 2 183 ? 130.158 147.129 132.408 1.00 48.11  ?  165 CYS B C   1 
ATOM   4685 O O   . CYS B 2 183 ? 130.679 147.534 131.355 1.00 48.11  ?  165 CYS B O   1 
ATOM   4686 C CB  . CYS B 2 183 ? 130.874 147.961 134.669 1.00 48.11  ?  165 CYS B CB  1 
ATOM   4687 S SG  . CYS B 2 183 ? 132.578 148.225 134.200 1.00 48.11  ?  165 CYS B SG  1 
ATOM   4688 N N   . ILE B 2 184 ? 129.804 145.852 132.595 1.00 46.36  ?  166 ILE B N   1 
ATOM   4689 C CA  . ILE B 2 184 ? 130.042 144.831 131.575 1.00 46.36  ?  166 ILE B CA  1 
ATOM   4690 C C   . ILE B 2 184 ? 129.221 145.118 130.321 1.00 46.36  ?  166 ILE B C   1 
ATOM   4691 O O   . ILE B 2 184 ? 129.744 145.070 129.198 1.00 46.36  ?  166 ILE B O   1 
ATOM   4692 C CB  . ILE B 2 184 ? 129.748 143.432 132.149 1.00 46.36  ?  166 ILE B CB  1 
ATOM   4693 C CG1 . ILE B 2 184 ? 130.900 142.973 133.038 1.00 46.36  ?  166 ILE B CG1 1 
ATOM   4694 C CG2 . ILE B 2 184 ? 129.509 142.407 131.051 1.00 46.36  ?  166 ILE B CG2 1 
ATOM   4695 C CD1 . ILE B 2 184 ? 130.654 141.652 133.724 1.00 46.36  ?  166 ILE B CD1 1 
ATOM   4696 N N   . CYS B 2 185 ? 127.939 145.470 130.495 1.00 48.58  ?  167 CYS B N   1 
ATOM   4697 C CA  . CYS B 2 185 ? 127.085 145.756 129.344 1.00 48.58  ?  167 CYS B CA  1 
ATOM   4698 C C   . CYS B 2 185 ? 127.516 147.016 128.598 1.00 48.58  ?  167 CYS B C   1 
ATOM   4699 O O   . CYS B 2 185 ? 127.462 147.046 127.361 1.00 48.58  ?  167 CYS B O   1 
ATOM   4700 C CB  . CYS B 2 185 ? 125.629 145.882 129.786 1.00 48.58  ?  167 CYS B CB  1 
ATOM   4701 S SG  . CYS B 2 185 ? 124.898 144.360 130.406 1.00 48.58  ?  167 CYS B SG  1 
ATOM   4702 N N   . LEU B 2 186 ? 127.988 148.039 129.320 1.00 45.73  ?  168 LEU B N   1 
ATOM   4703 C CA  . LEU B 2 186 ? 128.444 149.259 128.663 1.00 45.73  ?  168 LEU B CA  1 
ATOM   4704 C C   . LEU B 2 186 ? 129.712 149.022 127.850 1.00 45.73  ?  168 LEU B C   1 
ATOM   4705 O O   . LEU B 2 186 ? 129.821 149.500 126.711 1.00 45.73  ?  168 LEU B O   1 
ATOM   4706 C CB  . LEU B 2 186 ? 128.669 150.355 129.700 1.00 45.73  ?  168 LEU B CB  1 
ATOM   4707 C CG  . LEU B 2 186 ? 129.235 151.679 129.195 1.00 45.73  ?  168 LEU B CG  1 
ATOM   4708 C CD1 . LEU B 2 186 ? 128.256 152.332 128.249 1.00 45.73  ?  168 LEU B CD1 1 
ATOM   4709 C CD2 . LEU B 2 186 ? 129.550 152.594 130.353 1.00 45.73  ?  168 LEU B CD2 1 
ATOM   4710 N N   . LEU B 2 187 ? 130.675 148.275 128.402 1.00 44.30  ?  169 LEU B N   1 
ATOM   4711 C CA  . LEU B 2 187 ? 131.896 148.027 127.639 1.00 44.30  ?  169 LEU B CA  1 
ATOM   4712 C C   . LEU B 2 187 ? 131.652 147.077 126.470 1.00 44.30  ?  169 LEU B C   1 
ATOM   4713 O O   . LEU B 2 187 ? 132.301 147.210 125.421 1.00 44.30  ?  169 LEU B O   1 
ATOM   4714 C CB  . LEU B 2 187 ? 132.993 147.497 128.557 1.00 44.30  ?  169 LEU B CB  1 
ATOM   4715 C CG  . LEU B 2 187 ? 133.689 148.577 129.385 1.00 44.30  ?  169 LEU B CG  1 
ATOM   4716 C CD1 . LEU B 2 187 ? 134.752 147.976 130.282 1.00 44.30  ?  169 LEU B CD1 1 
ATOM   4717 C CD2 . LEU B 2 187 ? 134.282 149.646 128.487 1.00 44.30  ?  169 LEU B CD2 1 
ATOM   4718 N N   . THR B 2 188 ? 130.691 146.156 126.611 1.00 45.71  ?  170 THR B N   1 
ATOM   4719 C CA  . THR B 2 188 ? 130.308 145.297 125.496 1.00 45.71  ?  170 THR B CA  1 
ATOM   4720 C C   . THR B 2 188 ? 129.681 146.102 124.361 1.00 45.71  ?  170 THR B C   1 
ATOM   4721 O O   . THR B 2 188 ? 130.007 145.878 123.189 1.00 45.71  ?  170 THR B O   1 
ATOM   4722 C CB  . THR B 2 188 ? 129.355 144.209 125.989 1.00 45.71  ?  170 THR B CB  1 
ATOM   4723 O OG1 . THR B 2 188 ? 129.990 143.469 127.035 1.00 45.71  ?  170 THR B OG1 1 
ATOM   4724 C CG2 . THR B 2 188 ? 128.994 143.255 124.873 1.00 45.71  ?  170 THR B CG2 1 
ATOM   4725 N N   . PHE B 2 189 ? 128.812 147.066 124.695 1.00 48.81  ?  171 PHE B N   1 
ATOM   4726 C CA  . PHE B 2 189 ? 128.237 147.946 123.676 1.00 48.81  ?  171 PHE B CA  1 
ATOM   4727 C C   . PHE B 2 189 ? 129.306 148.787 122.987 1.00 48.81  ?  171 PHE B C   1 
ATOM   4728 O O   . PHE B 2 189 ? 129.275 148.955 121.759 1.00 48.81  ?  171 PHE B O   1 
ATOM   4729 C CB  . PHE B 2 189 ? 127.180 148.857 124.301 1.00 48.81  ?  171 PHE B CB  1 
ATOM   4730 C CG  . PHE B 2 189 ? 126.429 149.701 123.302 1.00 48.81  ?  171 PHE B CG  1 
ATOM   4731 C CD1 . PHE B 2 189 ? 125.317 149.195 122.656 1.00 48.81  ?  171 PHE B CD1 1 
ATOM   4732 C CD2 . PHE B 2 189 ? 126.825 151.005 123.021 1.00 48.81  ?  171 PHE B CD2 1 
ATOM   4733 C CE1 . PHE B 2 189 ? 124.624 149.958 121.744 1.00 48.81  ?  171 PHE B CE1 1 
ATOM   4734 C CE2 . PHE B 2 189 ? 126.140 151.768 122.103 1.00 48.81  ?  171 PHE B CE2 1 
ATOM   4735 C CZ  . PHE B 2 189 ? 125.036 151.245 121.468 1.00 48.81  ?  171 PHE B CZ  1 
ATOM   4736 N N   . ILE B 2 190 ? 130.246 149.335 123.765 1.00 45.55  ?  172 ILE B N   1 
ATOM   4737 C CA  . ILE B 2 190 ? 131.272 150.216 123.209 1.00 45.55  ?  172 ILE B CA  1 
ATOM   4738 C C   . ILE B 2 190 ? 132.183 149.450 122.255 1.00 45.55  ?  172 ILE B C   1 
ATOM   4739 O O   . ILE B 2 190 ? 132.523 149.941 121.171 1.00 45.55  ?  172 ILE B O   1 
ATOM   4740 C CB  . ILE B 2 190 ? 132.054 150.891 124.353 1.00 45.55  ?  172 ILE B CB  1 
ATOM   4741 C CG1 . ILE B 2 190 ? 131.282 152.103 124.863 1.00 45.55  ?  172 ILE B CG1 1 
ATOM   4742 C CG2 . ILE B 2 190 ? 133.449 151.316 123.929 1.00 45.55  ?  172 ILE B CG2 1 
ATOM   4743 C CD1 . ILE B 2 190 ? 131.735 152.574 126.205 1.00 45.55  ?  172 ILE B CD1 1 
ATOM   4744 N N   . ASN B 2 191 ? 132.536 148.214 122.604 1.00 43.55  ?  173 ASN B N   1 
ATOM   4745 C CA  . ASN B 2 191 ? 133.340 147.423 121.682 1.00 43.55  ?  173 ASN B CA  1 
ATOM   4746 C C   . ASN B 2 191 ? 132.537 146.869 120.510 1.00 43.55  ?  173 ASN B C   1 
ATOM   4747 O O   . ASN B 2 191 ? 133.119 146.613 119.453 1.00 43.55  ?  173 ASN B O   1 
ATOM   4748 C CB  . ASN B 2 191 ? 134.031 146.293 122.430 1.00 43.55  ?  173 ASN B CB  1 
ATOM   4749 C CG  . ASN B 2 191 ? 135.137 146.793 123.314 1.00 43.55  ?  173 ASN B CG  1 
ATOM   4750 O OD1 . ASN B 2 191 ? 136.173 147.235 122.831 1.00 43.55  ?  173 ASN B OD1 1 
ATOM   4751 N ND2 . ASN B 2 191 ? 134.919 146.745 124.619 1.00 43.55  ?  173 ASN B ND2 1 
ATOM   4752 N N   . CYS B 2 192 ? 131.223 146.697 120.655 1.00 47.16  ?  174 CYS B N   1 
ATOM   4753 C CA  . CYS B 2 192 ? 130.406 146.291 119.519 1.00 47.16  ?  174 CYS B CA  1 
ATOM   4754 C C   . CYS B 2 192 ? 130.152 147.426 118.539 1.00 47.16  ?  174 CYS B C   1 
ATOM   4755 O O   . CYS B 2 192 ? 129.817 147.158 117.382 1.00 47.16  ?  174 CYS B O   1 
ATOM   4756 C CB  . CYS B 2 192 ? 129.063 145.735 119.992 1.00 47.16  ?  174 CYS B CB  1 
ATOM   4757 S SG  . CYS B 2 192 ? 129.089 144.035 120.576 1.00 47.16  ?  174 CYS B SG  1 
ATOM   4758 N N   . ALA B 2 193 ? 130.282 148.680 118.970 1.00 47.42  ?  175 ALA B N   1 
ATOM   4759 C CA  . ALA B 2 193 ? 130.020 149.793 118.061 1.00 47.42  ?  175 ALA B CA  1 
ATOM   4760 C C   . ALA B 2 193 ? 131.171 150.005 117.081 1.00 47.42  ?  175 ALA B C   1 
ATOM   4761 O O   . ALA B 2 193 ? 130.984 149.917 115.865 1.00 47.42  ?  175 ALA B O   1 
ATOM   4762 C CB  . ALA B 2 193 ? 129.746 151.067 118.857 1.00 47.42  ?  175 ALA B CB  1 
ATOM   4763 N N   . TYR B 2 194 ? 132.365 150.297 117.591 1.00 48.18  ?  176 TYR B N   1 
ATOM   4764 C CA  . TYR B 2 194 ? 133.539 150.491 116.750 1.00 48.18  ?  176 TYR B CA  1 
ATOM   4765 C C   . TYR B 2 194 ? 134.769 150.005 117.499 1.00 48.18  ?  176 TYR B C   1 
ATOM   4766 O O   . TYR B 2 194 ? 134.771 149.907 118.727 1.00 48.18  ?  176 TYR B O   1 
ATOM   4767 C CB  . TYR B 2 194 ? 133.727 151.960 116.346 1.00 48.18  ?  176 TYR B CB  1 
ATOM   4768 C CG  . TYR B 2 194 ? 132.644 152.523 115.459 1.00 48.18  ?  176 TYR B CG  1 
ATOM   4769 C CD1 . TYR B 2 194 ? 132.662 152.308 114.088 1.00 48.18  ?  176 TYR B CD1 1 
ATOM   4770 C CD2 . TYR B 2 194 ? 131.605 153.270 115.992 1.00 48.18  ?  176 TYR B CD2 1 
ATOM   4771 C CE1 . TYR B 2 194 ? 131.674 152.821 113.275 1.00 48.18  ?  176 TYR B CE1 1 
ATOM   4772 C CE2 . TYR B 2 194 ? 130.612 153.785 115.189 1.00 48.18  ?  176 TYR B CE2 1 
ATOM   4773 C CZ  . TYR B 2 194 ? 130.653 153.557 113.832 1.00 48.18  ?  176 TYR B CZ  1 
ATOM   4774 O OH  . TYR B 2 194 ? 129.667 154.070 113.026 1.00 48.18  ?  176 TYR B OH  1 
ATOM   4775 N N   . VAL B 2 195 ? 135.826 149.711 116.744 1.00 47.25  ?  177 VAL B N   1 
ATOM   4776 C CA  . VAL B 2 195 ? 137.088 149.300 117.351 1.00 47.25  ?  177 VAL B CA  1 
ATOM   4777 C C   . VAL B 2 195 ? 137.856 150.510 117.877 1.00 47.25  ?  177 VAL B C   1 
ATOM   4778 O O   . VAL B 2 195 ? 138.533 150.428 118.918 1.00 47.25  ?  177 VAL B O   1 
ATOM   4779 C CB  . VAL B 2 195 ? 137.915 148.499 116.329 1.00 47.25  ?  177 VAL B CB  1 
ATOM   4780 C CG1 . VAL B 2 195 ? 139.100 147.822 116.989 1.00 47.25  ?  177 VAL B CG1 1 
ATOM   4781 C CG2 . VAL B 2 195 ? 137.045 147.473 115.645 1.00 47.25  ?  177 VAL B CG2 1 
ATOM   4782 N N   . LYS B 2 196 ? 137.742 151.647 117.184 1.00 49.78  ?  178 LYS B N   1 
ATOM   4783 C CA  . LYS B 2 196 ? 138.428 152.865 117.593 1.00 49.78  ?  178 LYS B CA  1 
ATOM   4784 C C   . LYS B 2 196 ? 137.887 153.407 118.906 1.00 49.78  ?  178 LYS B C   1 
ATOM   4785 O O   . LYS B 2 196 ? 138.635 154.024 119.670 1.00 49.78  ?  178 LYS B O   1 
ATOM   4786 C CB  . LYS B 2 196 ? 138.312 153.920 116.498 1.00 49.78  ?  178 LYS B CB  1 
ATOM   4787 C CG  . LYS B 2 196 ? 138.816 153.451 115.154 1.00 49.78  ?  178 LYS B CG  1 
ATOM   4788 C CD  . LYS B 2 196 ? 140.278 153.057 115.222 1.00 49.78  ?  178 LYS B CD  1 
ATOM   4789 C CE  . LYS B 2 196 ? 141.181 154.251 114.988 1.00 49.78  ?  178 LYS B CE  1 
ATOM   4790 N NZ  . LYS B 2 196 ? 140.957 154.845 113.643 1.00 49.78  1  178 LYS B NZ  1 
ATOM   4791 N N   . TRP B 2 197 ? 136.609 153.159 119.196 1.00 49.65  ?  179 TRP B N   1 
ATOM   4792 C CA  . TRP B 2 197 ? 136.039 153.566 120.475 1.00 49.65  ?  179 TRP B CA  1 
ATOM   4793 C C   . TRP B 2 197 ? 136.660 152.784 121.626 1.00 49.65  ?  179 TRP B C   1 
ATOM   4794 O O   . TRP B 2 197 ? 136.975 153.359 122.677 1.00 49.65  ?  179 TRP B O   1 
ATOM   4795 C CB  . TRP B 2 197 ? 134.523 153.380 120.450 1.00 49.65  ?  179 TRP B CB  1 
ATOM   4796 C CG  . TRP B 2 197 ? 133.788 154.383 119.601 1.00 49.65  ?  179 TRP B CG  1 
ATOM   4797 C CD1 . TRP B 2 197 ? 134.325 155.255 118.701 1.00 49.65  ?  179 TRP B CD1 1 
ATOM   4798 C CD2 . TRP B 2 197 ? 132.376 154.611 119.581 1.00 49.65  ?  179 TRP B CD2 1 
ATOM   4799 N NE1 . TRP B 2 197 ? 133.340 156.005 118.123 1.00 49.65  ?  179 TRP B NE1 1 
ATOM   4800 C CE2 . TRP B 2 197 ? 132.132 155.632 118.647 1.00 49.65  ?  179 TRP B CE2 1 
ATOM   4801 C CE3 . TRP B 2 197 ? 131.295 154.054 120.266 1.00 49.65  ?  179 TRP B CE3 1 
ATOM   4802 C CZ2 . TRP B 2 197 ? 130.855 156.107 118.379 1.00 49.65  ?  179 TRP B CZ2 1 
ATOM   4803 C CZ3 . TRP B 2 197 ? 130.029 154.524 119.997 1.00 49.65  ?  179 TRP B CZ3 1 
ATOM   4804 C CH2 . TRP B 2 197 ? 129.818 155.539 119.062 1.00 49.65  ?  179 TRP B CH2 1 
ATOM   4805 N N   . GLY B 2 198 ? 136.879 151.483 121.429 1.00 46.67  ?  180 GLY B N   1 
ATOM   4806 C CA  . GLY B 2 198 ? 137.533 150.683 122.450 1.00 46.67  ?  180 GLY B CA  1 
ATOM   4807 C C   . GLY B 2 198 ? 138.988 151.057 122.652 1.00 46.67  ?  180 GLY B C   1 
ATOM   4808 O O   . GLY B 2 198 ? 139.472 151.098 123.789 1.00 46.67  ?  180 GLY B O   1 
ATOM   4809 N N   . THR B 2 199 ? 139.702 151.358 121.561 1.00 48.56  ?  181 THR B N   1 
ATOM   4810 C CA  . THR B 2 199 ? 141.089 151.796 121.714 1.00 48.56  ?  181 THR B CA  1 
ATOM   4811 C C   . THR B 2 199 ? 141.187 153.174 122.365 1.00 48.56  ?  181 THR B C   1 
ATOM   4812 O O   . THR B 2 199 ? 142.122 153.428 123.135 1.00 48.56  ?  181 THR B O   1 
ATOM   4813 C CB  . THR B 2 199 ? 141.806 151.794 120.367 1.00 48.56  ?  181 THR B CB  1 
ATOM   4814 O OG1 . THR B 2 199 ? 141.178 152.729 119.486 1.00 48.56  ?  181 THR B OG1 1 
ATOM   4815 C CG2 . THR B 2 199 ? 141.770 150.409 119.747 1.00 48.56  ?  181 THR B CG2 1 
ATOM   4816 N N   . LEU B 2 200 ? 140.211 154.052 122.113 1.00 47.81  ?  182 LEU B N   1 
ATOM   4817 C CA  . LEU B 2 200 ? 140.188 155.356 122.769 1.00 47.81  ?  182 LEU B CA  1 
ATOM   4818 C C   . LEU B 2 200 ? 139.916 155.228 124.263 1.00 47.81  ?  182 LEU B C   1 
ATOM   4819 O O   . LEU B 2 200 ? 140.550 155.922 125.072 1.00 47.81  ?  182 LEU B O   1 
ATOM   4820 C CB  . LEU B 2 200 ? 139.136 156.244 122.109 1.00 47.81  ?  182 LEU B CB  1 
ATOM   4821 C CG  . LEU B 2 200 ? 139.136 157.712 122.516 1.00 47.81  ?  182 LEU B CG  1 
ATOM   4822 C CD1 . LEU B 2 200 ? 140.486 158.327 122.230 1.00 47.81  ?  182 LEU B CD1 1 
ATOM   4823 C CD2 . LEU B 2 200 ? 138.046 158.456 121.779 1.00 47.81  ?  182 LEU B CD2 1 
ATOM   4824 N N   . VAL B 2 201 ? 138.973 154.353 124.639 1.00 46.07  ?  183 VAL B N   1 
ATOM   4825 C CA  . VAL B 2 201 ? 138.692 154.079 126.049 1.00 46.07  ?  183 VAL B CA  1 
ATOM   4826 C C   . VAL B 2 201 ? 139.931 153.530 126.750 1.00 46.07  ?  183 VAL B C   1 
ATOM   4827 O O   . VAL B 2 201 ? 140.277 153.957 127.866 1.00 46.07  ?  183 VAL B O   1 
ATOM   4828 C CB  . VAL B 2 201 ? 137.494 153.116 126.160 1.00 46.07  ?  183 VAL B CB  1 
ATOM   4829 C CG1 . VAL B 2 201 ? 137.415 152.472 127.530 1.00 46.07  ?  183 VAL B CG1 1 
ATOM   4830 C CG2 . VAL B 2 201 ? 136.208 153.842 125.857 1.00 46.07  ?  183 VAL B CG2 1 
ATOM   4831 N N   . GLN B 2 202 ? 140.640 152.609 126.082 1.00 45.34  ?  184 GLN B N   1 
ATOM   4832 C CA  . GLN B 2 202 ? 141.874 152.052 126.629 1.00 45.34  ?  184 GLN B CA  1 
ATOM   4833 C C   . GLN B 2 202 ? 142.936 153.124 126.846 1.00 45.34  ?  184 GLN B C   1 
ATOM   4834 O O   . GLN B 2 202 ? 143.587 153.148 127.900 1.00 45.34  ?  184 GLN B O   1 
ATOM   4835 C CB  . GLN B 2 202 ? 142.399 150.958 125.702 1.00 45.34  ?  184 GLN B CB  1 
ATOM   4836 C CG  . GLN B 2 202 ? 143.407 150.033 126.343 1.00 45.34  ?  184 GLN B CG  1 
ATOM   4837 C CD  . GLN B 2 202 ? 142.804 149.208 127.451 1.00 45.34  ?  184 GLN B CD  1 
ATOM   4838 O OE1 . GLN B 2 202 ? 141.636 148.836 127.396 1.00 45.34  ?  184 GLN B OE1 1 
ATOM   4839 N NE2 . GLN B 2 202 ? 143.596 148.919 128.469 1.00 45.34  ?  184 GLN B NE2 1 
ATOM   4840 N N   . ASP B 2 203 ? 143.085 154.043 125.881 1.00 49.57  ?  185 ASP B N   1 
ATOM   4841 C CA  . ASP B 2 203 ? 144.059 155.129 126.007 1.00 49.57  ?  185 ASP B CA  1 
ATOM   4842 C C   . ASP B 2 203 ? 143.739 156.040 127.189 1.00 49.57  ?  185 ASP B C   1 
ATOM   4843 O O   . ASP B 2 203 ? 144.624 156.353 128.000 1.00 49.57  ?  185 ASP B O   1 
ATOM   4844 C CB  . ASP B 2 203 ? 144.112 155.948 124.715 1.00 49.57  ?  185 ASP B CB  1 
ATOM   4845 C CG  . ASP B 2 203 ? 144.719 155.185 123.553 1.00 49.57  ?  185 ASP B CG  1 
ATOM   4846 O OD1 . ASP B 2 203 ? 145.517 154.262 123.789 1.00 49.57  ?  185 ASP B OD1 1 
ATOM   4847 O OD2 . ASP B 2 203 ? 144.412 155.525 122.391 1.00 49.57  -1 185 ASP B OD2 1 
ATOM   4848 N N   . ILE B 2 204 ? 142.466 156.439 127.320 1.00 47.30  ?  186 ILE B N   1 
ATOM   4849 C CA  . ILE B 2 204 ? 142.065 157.387 128.363 1.00 47.30  ?  186 ILE B CA  1 
ATOM   4850 C C   . ILE B 2 204 ? 142.267 156.789 129.753 1.00 47.30  ?  186 ILE B C   1 
ATOM   4851 O O   . ILE B 2 204 ? 142.869 157.415 130.640 1.00 47.30  ?  186 ILE B O   1 
ATOM   4852 C CB  . ILE B 2 204 ? 140.606 157.834 128.151 1.00 47.30  ?  186 ILE B CB  1 
ATOM   4853 C CG1 . ILE B 2 204 ? 140.466 158.638 126.859 1.00 47.30  ?  186 ILE B CG1 1 
ATOM   4854 C CG2 . ILE B 2 204 ? 140.118 158.667 129.320 1.00 47.30  ?  186 ILE B CG2 1 
ATOM   4855 C CD1 . ILE B 2 204 ? 141.408 159.804 126.752 1.00 47.30  ?  186 ILE B CD1 1 
ATOM   4856 N N   . PHE B 2 205 ? 141.816 155.551 129.956 1.00 47.13  ?  187 PHE B N   1 
ATOM   4857 C CA  . PHE B 2 205 ? 141.921 154.999 131.301 1.00 47.13  ?  187 PHE B CA  1 
ATOM   4858 C C   . PHE B 2 205 ? 143.328 154.509 131.640 1.00 47.13  ?  187 PHE B C   1 
ATOM   4859 O O   . PHE B 2 205 ? 143.697 154.507 132.826 1.00 47.13  ?  187 PHE B O   1 
ATOM   4860 C CB  . PHE B 2 205 ? 140.869 153.911 131.489 1.00 47.13  ?  187 PHE B CB  1 
ATOM   4861 C CG  . PHE B 2 205 ? 139.476 154.460 131.596 1.00 47.13  ?  187 PHE B CG  1 
ATOM   4862 C CD1 . PHE B 2 205 ? 138.991 154.914 132.806 1.00 47.13  ?  187 PHE B CD1 1 
ATOM   4863 C CD2 . PHE B 2 205 ? 138.668 154.569 130.479 1.00 47.13  ?  187 PHE B CD2 1 
ATOM   4864 C CE1 . PHE B 2 205 ? 137.716 155.441 132.902 1.00 47.13  ?  187 PHE B CE1 1 
ATOM   4865 C CE2 . PHE B 2 205 ? 137.396 155.096 130.568 1.00 47.13  ?  187 PHE B CE2 1 
ATOM   4866 C CZ  . PHE B 2 205 ? 136.921 155.531 131.782 1.00 47.13  ?  187 PHE B CZ  1 
ATOM   4867 N N   . THR B 2 206 ? 144.152 154.187 130.635 1.00 47.17  ?  188 THR B N   1 
ATOM   4868 C CA  . THR B 2 206 ? 145.559 153.918 130.906 1.00 47.17  ?  188 THR B CA  1 
ATOM   4869 C C   . THR B 2 206 ? 146.288 155.183 131.344 1.00 47.17  ?  188 THR B C   1 
ATOM   4870 O O   . THR B 2 206 ? 147.089 155.143 132.291 1.00 47.17  ?  188 THR B O   1 
ATOM   4871 C CB  . THR B 2 206 ? 146.216 153.308 129.668 1.00 47.17  ?  188 THR B CB  1 
ATOM   4872 O OG1 . THR B 2 206 ? 145.477 152.151 129.269 1.00 47.17  ?  188 THR B OG1 1 
ATOM   4873 C CG2 . THR B 2 206 ? 147.643 152.895 129.957 1.00 47.17  ?  188 THR B CG2 1 
ATOM   4874 N N   . TYR B 2 207 ? 145.995 156.318 130.688 1.00 49.28  ?  189 TYR B N   1 
ATOM   4875 C CA  . TYR B 2 207 ? 146.561 157.598 131.117 1.00 49.28  ?  189 TYR B CA  1 
ATOM   4876 C C   . TYR B 2 207 ? 146.129 157.953 132.534 1.00 49.28  ?  189 TYR B C   1 
ATOM   4877 O O   . TYR B 2 207 ? 146.934 158.467 133.324 1.00 49.28  ?  189 TYR B O   1 
ATOM   4878 C CB  . TYR B 2 207 ? 146.144 158.721 130.168 1.00 49.28  ?  189 TYR B CB  1 
ATOM   4879 C CG  . TYR B 2 207 ? 146.630 158.603 128.746 1.00 49.28  ?  189 TYR B CG  1 
ATOM   4880 C CD1 . TYR B 2 207 ? 147.764 157.868 128.428 1.00 49.28  ?  189 TYR B CD1 1 
ATOM   4881 C CD2 . TYR B 2 207 ? 145.950 159.240 127.718 1.00 49.28  ?  189 TYR B CD2 1 
ATOM   4882 C CE1 . TYR B 2 207 ? 148.200 157.766 127.123 1.00 49.28  ?  189 TYR B CE1 1 
ATOM   4883 C CE2 . TYR B 2 207 ? 146.375 159.144 126.416 1.00 49.28  ?  189 TYR B CE2 1 
ATOM   4884 C CZ  . TYR B 2 207 ? 147.499 158.410 126.125 1.00 49.28  ?  189 TYR B CZ  1 
ATOM   4885 O OH  . TYR B 2 207 ? 147.917 158.326 124.824 1.00 49.28  ?  189 TYR B OH  1 
ATOM   4886 N N   . ALA B 2 208 ? 144.868 157.661 132.874 1.00 47.58  ?  190 ALA B N   1 
ATOM   4887 C CA  . ALA B 2 208 ? 144.354 157.962 134.210 1.00 47.58  ?  190 ALA B CA  1 
ATOM   4888 C C   . ALA B 2 208 ? 145.084 157.169 135.291 1.00 47.58  ?  190 ALA B C   1 
ATOM   4889 O O   . ALA B 2 208 ? 145.532 157.738 136.301 1.00 47.58  ?  190 ALA B O   1 
ATOM   4890 C CB  . ALA B 2 208 ? 142.855 157.683 134.263 1.00 47.58  ?  190 ALA B CB  1 
ATOM   4891 N N   . LYS B 2 209 ? 145.231 155.852 135.090 1.00 47.79  ?  191 LYS B N   1 
ATOM   4892 C CA  . LYS B 2 209 ? 145.892 155.046 136.116 1.00 47.79  ?  191 LYS B CA  1 
ATOM   4893 C C   . LYS B 2 209 ? 147.387 155.352 136.212 1.00 47.79  ?  191 LYS B C   1 
ATOM   4894 O O   . LYS B 2 209 ? 147.949 155.326 137.319 1.00 47.79  ?  191 LYS B O   1 
ATOM   4895 C CB  . LYS B 2 209 ? 145.634 153.552 135.879 1.00 47.79  ?  191 LYS B CB  1 
ATOM   4896 C CG  . LYS B 2 209 ? 146.369 152.905 134.724 1.00 47.79  ?  191 LYS B CG  1 
ATOM   4897 C CD  . LYS B 2 209 ? 146.138 151.409 134.697 1.00 47.79  ?  191 LYS B CD  1 
ATOM   4898 C CE  . LYS B 2 209 ? 144.793 151.070 134.087 1.00 47.79  ?  191 LYS B CE  1 
ATOM   4899 N NZ  . LYS B 2 209 ? 144.571 149.604 134.053 1.00 47.79  1  191 LYS B NZ  1 
ATOM   4900 N N   . VAL B 2 210 ? 148.028 155.720 135.096 1.00 48.89  ?  192 VAL B N   1 
ATOM   4901 C CA  . VAL B 2 210 ? 149.447 156.058 135.149 1.00 48.89  ?  192 VAL B CA  1 
ATOM   4902 C C   . VAL B 2 210 ? 149.655 157.388 135.871 1.00 48.89  ?  192 VAL B C   1 
ATOM   4903 O O   . VAL B 2 210 ? 150.599 157.536 136.658 1.00 48.89  ?  192 VAL B O   1 
ATOM   4904 C CB  . VAL B 2 210 ? 150.039 156.047 133.725 1.00 48.89  ?  192 VAL B CB  1 
ATOM   4905 C CG1 . VAL B 2 210 ? 151.376 156.760 133.651 1.00 48.89  ?  192 VAL B CG1 1 
ATOM   4906 C CG2 . VAL B 2 210 ? 150.207 154.617 133.254 1.00 48.89  ?  192 VAL B CG2 1 
ATOM   4907 N N   . LEU B 2 211 ? 148.737 158.347 135.683 1.00 50.15  ?  193 LEU B N   1 
ATOM   4908 C CA  . LEU B 2 211 ? 148.840 159.620 136.396 1.00 50.15  ?  193 LEU B CA  1 
ATOM   4909 C C   . LEU B 2 211 ? 148.622 159.449 137.896 1.00 50.15  ?  193 LEU B C   1 
ATOM   4910 O O   . LEU B 2 211 ? 149.303 160.094 138.704 1.00 50.15  ?  193 LEU B O   1 
ATOM   4911 C CB  . LEU B 2 211 ? 147.841 160.624 135.828 1.00 50.15  ?  193 LEU B CB  1 
ATOM   4912 C CG  . LEU B 2 211 ? 148.273 161.354 134.559 1.00 50.15  ?  193 LEU B CG  1 
ATOM   4913 C CD1 . LEU B 2 211 ? 147.249 162.405 134.183 1.00 50.15  ?  193 LEU B CD1 1 
ATOM   4914 C CD2 . LEU B 2 211 ? 149.640 161.979 134.739 1.00 50.15  ?  193 LEU B CD2 1 
ATOM   4915 N N   . ALA B 2 212 ? 147.700 158.563 138.286 1.00 49.70  ?  194 ALA B N   1 
ATOM   4916 C CA  . ALA B 2 212 ? 147.492 158.300 139.711 1.00 49.70  ?  194 ALA B CA  1 
ATOM   4917 C C   . ALA B 2 212 ? 148.709 157.638 140.357 1.00 49.70  ?  194 ALA B C   1 
ATOM   4918 O O   . ALA B 2 212 ? 149.121 158.019 141.467 1.00 49.70  ?  194 ALA B O   1 
ATOM   4919 C CB  . ALA B 2 212 ? 146.260 157.430 139.901 1.00 49.70  ?  194 ALA B CB  1 
ATOM   4920 N N   . LEU B 2 213 ? 149.303 156.652 139.676 1.00 49.27  ?  195 LEU B N   1 
ATOM   4921 C CA  . LEU B 2 213 ? 150.498 156.014 140.222 1.00 49.27  ?  195 LEU B CA  1 
ATOM   4922 C C   . LEU B 2 213 ? 151.688 156.965 140.253 1.00 49.27  ?  195 LEU B C   1 
ATOM   4923 O O   . LEU B 2 213 ? 152.510 156.888 141.172 1.00 49.27  ?  195 LEU B O   1 
ATOM   4924 C CB  . LEU B 2 213 ? 150.835 154.761 139.422 1.00 49.27  ?  195 LEU B CB  1 
ATOM   4925 C CG  . LEU B 2 213 ? 149.966 153.562 139.791 1.00 49.27  ?  195 LEU B CG  1 
ATOM   4926 C CD1 . LEU B 2 213 ? 150.172 152.428 138.816 1.00 49.27  ?  195 LEU B CD1 1 
ATOM   4927 C CD2 . LEU B 2 213 ? 150.259 153.115 141.207 1.00 49.27  ?  195 LEU B CD2 1 
ATOM   4928 N N   . ILE B 2 214 ? 151.774 157.885 139.288 1.00 50.23  ?  196 ILE B N   1 
ATOM   4929 C CA  . ILE B 2 214 ? 152.831 158.893 139.292 1.00 50.23  ?  196 ILE B CA  1 
ATOM   4930 C C   . ILE B 2 214 ? 152.655 159.848 140.468 1.00 50.23  ?  196 ILE B C   1 
ATOM   4931 O O   . ILE B 2 214 ? 153.636 160.249 141.107 1.00 50.23  ?  196 ILE B O   1 
ATOM   4932 C CB  . ILE B 2 214 ? 152.854 159.619 137.930 1.00 50.23  ?  196 ILE B CB  1 
ATOM   4933 C CG1 . ILE B 2 214 ? 153.649 158.800 136.914 1.00 50.23  ?  196 ILE B CG1 1 
ATOM   4934 C CG2 . ILE B 2 214 ? 153.432 161.029 138.017 1.00 50.23  ?  196 ILE B CG2 1 
ATOM   4935 C CD1 . ILE B 2 214 ? 153.627 159.374 135.520 1.00 50.23  ?  196 ILE B CD1 1 
ATOM   4936 N N   . ALA B 2 215 ? 151.403 160.181 140.807 1.00 50.30  ?  197 ALA B N   1 
ATOM   4937 C CA  . ALA B 2 215 ? 151.138 161.015 141.980 1.00 50.30  ?  197 ALA B CA  1 
ATOM   4938 C C   . ALA B 2 215 ? 151.567 160.329 143.274 1.00 50.30  ?  197 ALA B C   1 
ATOM   4939 O O   . ALA B 2 215 ? 152.183 160.962 144.146 1.00 50.30  ?  197 ALA B O   1 
ATOM   4940 C CB  . ALA B 2 215 ? 149.656 161.377 142.041 1.00 50.30  ?  197 ALA B CB  1 
ATOM   4941 N N   . VAL B 2 216 ? 151.268 159.030 143.402 1.00 50.45  ?  198 VAL B N   1 
ATOM   4942 C CA  . VAL B 2 216 ? 151.685 158.271 144.588 1.00 50.45  ?  198 VAL B CA  1 
ATOM   4943 C C   . VAL B 2 216 ? 153.210 158.198 144.685 1.00 50.45  ?  198 VAL B C   1 
ATOM   4944 O O   . VAL B 2 216 ? 153.790 158.411 145.763 1.00 50.45  ?  198 VAL B O   1 
ATOM   4945 C CB  . VAL B 2 216 ? 151.044 156.870 144.571 1.00 50.45  ?  198 VAL B CB  1 
ATOM   4946 C CG1 . VAL B 2 216 ? 151.649 155.967 145.630 1.00 50.45  ?  198 VAL B CG1 1 
ATOM   4947 C CG2 . VAL B 2 216 ? 149.550 156.976 144.773 1.00 50.45  ?  198 VAL B CG2 1 
ATOM   4948 N N   . ILE B 2 217 ? 153.878 157.948 143.552 1.00 51.37  ?  199 ILE B N   1 
ATOM   4949 C CA  . ILE B 2 217 ? 155.338 157.861 143.513 1.00 51.37  ?  199 ILE B CA  1 
ATOM   4950 C C   . ILE B 2 217 ? 155.977 159.198 143.881 1.00 51.37  ?  199 ILE B C   1 
ATOM   4951 O O   . ILE B 2 217 ? 156.930 159.242 144.663 1.00 51.37  ?  199 ILE B O   1 
ATOM   4952 C CB  . ILE B 2 217 ? 155.797 157.369 142.126 1.00 51.37  ?  199 ILE B CB  1 
ATOM   4953 C CG1 . ILE B 2 217 ? 155.514 155.879 141.961 1.00 51.37  ?  199 ILE B CG1 1 
ATOM   4954 C CG2 . ILE B 2 217 ? 157.276 157.619 141.894 1.00 51.37  ?  199 ILE B CG2 1 
ATOM   4955 C CD1 . ILE B 2 217 ? 155.485 155.437 140.521 1.00 51.37  ?  199 ILE B CD1 1 
ATOM   4956 N N   . VAL B 2 218 ? 155.434 160.305 143.366 1.00 54.69  ?  200 VAL B N   1 
ATOM   4957 C CA  . VAL B 2 218 ? 156.015 161.624 143.614 1.00 54.69  ?  200 VAL B CA  1 
ATOM   4958 C C   . VAL B 2 218 ? 155.828 162.034 145.074 1.00 54.69  ?  200 VAL B C   1 
ATOM   4959 O O   . VAL B 2 218 ? 156.744 162.600 145.689 1.00 54.69  ?  200 VAL B O   1 
ATOM   4960 C CB  . VAL B 2 218 ? 155.416 162.647 142.626 1.00 54.69  ?  200 VAL B CB  1 
ATOM   4961 C CG1 . VAL B 2 218 ? 155.545 164.079 143.121 1.00 54.69  ?  200 VAL B CG1 1 
ATOM   4962 C CG2 . VAL B 2 218 ? 156.089 162.517 141.278 1.00 54.69  ?  200 VAL B CG2 1 
ATOM   4963 N N   . ALA B 2 219 ? 154.672 161.703 145.668 1.00 56.35  ?  201 ALA B N   1 
ATOM   4964 C CA  . ALA B 2 219 ? 154.469 161.964 147.094 1.00 56.35  ?  201 ALA B CA  1 
ATOM   4965 C C   . ALA B 2 219 ? 155.438 161.161 147.959 1.00 56.35  ?  201 ALA B C   1 
ATOM   4966 O O   . ALA B 2 219 ? 156.025 161.698 148.911 1.00 56.35  ?  201 ALA B O   1 
ATOM   4967 C CB  . ALA B 2 219 ? 153.027 161.652 147.483 1.00 56.35  ?  201 ALA B CB  1 
ATOM   4968 N N   . GLY B 2 220 ? 155.651 159.885 147.615 1.00 58.87  ?  202 GLY B N   1 
ATOM   4969 C CA  . GLY B 2 220 ? 156.609 159.079 148.358 1.00 58.87  ?  202 GLY B CA  1 
ATOM   4970 C C   . GLY B 2 220 ? 158.042 159.563 148.218 1.00 58.87  ?  202 GLY B C   1 
ATOM   4971 O O   . GLY B 2 220 ? 158.795 159.579 149.192 1.00 58.87  ?  202 GLY B O   1 
ATOM   4972 N N   . ILE B 2 221 ? 158.427 159.993 147.013 1.00 61.20  ?  203 ILE B N   1 
ATOM   4973 C CA  . ILE B 2 221 ? 159.793 160.461 146.778 1.00 61.20  ?  203 ILE B CA  1 
ATOM   4974 C C   . ILE B 2 221 ? 160.043 161.789 147.487 1.00 61.20  ?  203 ILE B C   1 
ATOM   4975 O O   . ILE B 2 221 ? 161.119 162.004 148.061 1.00 61.20  ?  203 ILE B O   1 
ATOM   4976 C CB  . ILE B 2 221 ? 160.073 160.543 145.261 1.00 61.20  ?  203 ILE B CB  1 
ATOM   4977 C CG1 . ILE B 2 221 ? 160.147 159.143 144.647 1.00 61.20  ?  203 ILE B CG1 1 
ATOM   4978 C CG2 . ILE B 2 221 ? 161.355 161.294 144.944 1.00 61.20  ?  203 ILE B CG2 1 
ATOM   4979 C CD1 . ILE B 2 221 ? 161.149 158.230 145.310 1.00 61.20  ?  203 ILE B CD1 1 
ATOM   4980 N N   . VAL B 2 222 ? 159.048 162.683 147.504 1.00 63.45  ?  204 VAL B N   1 
ATOM   4981 C CA  . VAL B 2 222 ? 159.264 163.961 148.175 1.00 63.45  ?  204 VAL B CA  1 
ATOM   4982 C C   . VAL B 2 222 ? 159.254 163.787 149.693 1.00 63.45  ?  204 VAL B C   1 
ATOM   4983 O O   . VAL B 2 222 ? 159.990 164.485 150.397 1.00 63.45  ?  204 VAL B O   1 
ATOM   4984 C CB  . VAL B 2 222 ? 158.259 165.028 147.682 1.00 63.45  ?  204 VAL B CB  1 
ATOM   4985 C CG1 . VAL B 2 222 ? 156.854 164.820 148.226 1.00 63.45  ?  204 VAL B CG1 1 
ATOM   4986 C CG2 . VAL B 2 222 ? 158.756 166.422 148.017 1.00 63.45  ?  204 VAL B CG2 1 
ATOM   4987 N N   . ARG B 2 223 ? 158.506 162.809 150.223 1.00 67.05  ?  205 ARG B N   1 
ATOM   4988 C CA  . ARG B 2 223 ? 158.588 162.562 151.660 1.00 67.05  ?  205 ARG B CA  1 
ATOM   4989 C C   . ARG B 2 223 ? 159.871 161.826 152.032 1.00 67.05  ?  205 ARG B C   1 
ATOM   4990 O O   . ARG B 2 223 ? 160.393 162.012 153.137 1.00 67.05  ?  205 ARG B O   1 
ATOM   4991 C CB  . ARG B 2 223 ? 157.363 161.784 152.134 1.00 67.05  ?  205 ARG B CB  1 
ATOM   4992 C CG  . ARG B 2 223 ? 157.211 161.736 153.641 1.00 67.05  ?  205 ARG B CG  1 
ATOM   4993 C CD  . ARG B 2 223 ? 155.771 161.577 154.056 1.00 67.05  ?  205 ARG B CD  1 
ATOM   4994 N NE  . ARG B 2 223 ? 155.661 160.992 155.387 1.00 67.05  ?  205 ARG B NE  1 
ATOM   4995 C CZ  . ARG B 2 223 ? 154.539 160.966 156.096 1.00 67.05  ?  205 ARG B CZ  1 
ATOM   4996 N NH1 . ARG B 2 223 ? 153.431 161.500 155.603 1.00 67.05  1  205 ARG B NH1 1 
ATOM   4997 N NH2 . ARG B 2 223 ? 154.526 160.410 157.299 1.00 67.05  ?  205 ARG B NH2 1 
ATOM   4998 N N   . LEU B 2 224 ? 160.406 161.009 151.123 1.00 67.98  ?  206 LEU B N   1 
ATOM   4999 C CA  . LEU B 2 224 ? 161.655 160.304 151.390 1.00 67.98  ?  206 LEU B CA  1 
ATOM   5000 C C   . LEU B 2 224 ? 162.837 161.262 151.382 1.00 67.98  ?  206 LEU B C   1 
ATOM   5001 O O   . LEU B 2 224 ? 163.609 161.326 152.344 1.00 67.98  ?  206 LEU B O   1 
ATOM   5002 C CB  . LEU B 2 224 ? 161.854 159.196 150.357 1.00 67.98  ?  206 LEU B CB  1 
ATOM   5003 C CG  . LEU B 2 224 ? 163.239 158.565 150.260 1.00 67.98  ?  206 LEU B CG  1 
ATOM   5004 C CD1 . LEU B 2 224 ? 163.486 157.657 151.442 1.00 67.98  ?  206 LEU B CD1 1 
ATOM   5005 C CD2 . LEU B 2 224 ? 163.363 157.797 148.962 1.00 67.98  ?  206 LEU B CD2 1 
ATOM   5006 N N   . GLY B 2 225 ? 162.994 162.019 150.298 1.00 71.31  ?  207 GLY B N   1 
ATOM   5007 C CA  . GLY B 2 225 ? 164.108 162.941 150.210 1.00 71.31  ?  207 GLY B CA  1 
ATOM   5008 C C   . GLY B 2 225 ? 163.946 164.191 151.043 1.00 71.31  ?  207 GLY B C   1 
ATOM   5009 O O   . GLY B 2 225 ? 164.939 164.884 151.290 1.00 71.31  ?  207 GLY B O   1 
ATOM   5010 N N   . GLN B 2 226 ? 162.718 164.514 151.457 1.00 76.10  ?  208 GLN B N   1 
ATOM   5011 C CA  . GLN B 2 226 ? 162.467 165.730 152.217 1.00 76.10  ?  208 GLN B CA  1 
ATOM   5012 C C   . GLN B 2 226 ? 163.120 165.725 153.592 1.00 76.10  ?  208 GLN B C   1 
ATOM   5013 O O   . GLN B 2 226 ? 164.080 166.466 153.823 1.00 76.10  ?  208 GLN B O   1 
ATOM   5014 C CB  . GLN B 2 226 ? 160.961 165.940 152.366 1.00 76.10  ?  208 GLN B CB  1 
ATOM   5015 C CG  . GLN B 2 226 ? 160.562 167.245 153.015 1.00 76.10  ?  208 GLN B CG  1 
ATOM   5016 C CD  . GLN B 2 226 ? 159.079 167.302 153.301 1.00 76.10  ?  208 GLN B CD  1 
ATOM   5017 O OE1 . GLN B 2 226 ? 158.389 168.230 152.883 1.00 76.10  ?  208 GLN B OE1 1 
ATOM   5018 N NE2 . GLN B 2 226 ? 158.577 166.302 154.015 1.00 76.10  ?  208 GLN B NE2 1 
ATOM   5019 N N   . GLY B 2 227 ? 162.628 164.896 154.509 1.00 78.67  ?  209 GLY B N   1 
ATOM   5020 C CA  . GLY B 2 227 ? 163.196 164.940 155.840 1.00 78.67  ?  209 GLY B CA  1 
ATOM   5021 C C   . GLY B 2 227 ? 163.229 163.695 156.701 1.00 78.67  ?  209 GLY B C   1 
ATOM   5022 O O   . GLY B 2 227 ? 163.643 163.792 157.859 1.00 78.67  ?  209 GLY B O   1 
ATOM   5023 N N   . ALA B 2 228 ? 162.819 162.528 156.203 1.00 82.46  ?  210 ALA B N   1 
ATOM   5024 C CA  . ALA B 2 228 ? 162.715 161.356 157.067 1.00 82.46  ?  210 ALA B CA  1 
ATOM   5025 C C   . ALA B 2 228 ? 163.705 160.261 156.684 1.00 82.46  ?  210 ALA B C   1 
ATOM   5026 O O   . ALA B 2 228 ? 164.668 160.038 157.424 1.00 82.46  ?  210 ALA B O   1 
ATOM   5027 C CB  . ALA B 2 228 ? 161.280 160.826 157.046 1.00 82.46  ?  210 ALA B CB  1 
ATOM   5028 N N   . SER B 2 229 ? 163.543 159.644 155.502 1.00 83.15  ?  211 SER B N   1 
ATOM   5029 C CA  . SER B 2 229 ? 164.345 158.501 155.016 1.00 83.15  ?  211 SER B CA  1 
ATOM   5030 C C   . SER B 2 229 ? 164.545 157.404 156.071 1.00 83.15  ?  211 SER B C   1 
ATOM   5031 O O   . SER B 2 229 ? 165.601 156.773 156.135 1.00 83.15  ?  211 SER B O   1 
ATOM   5032 C CB  . SER B 2 229 ? 165.697 158.977 154.478 1.00 83.15  ?  211 SER B CB  1 
ATOM   5033 O OG  . SER B 2 229 ? 166.635 157.917 154.431 1.00 83.15  ?  211 SER B OG  1 
ATOM   5034 N N   . THR B 2 230 ? 163.529 157.153 156.901 1.00 83.15  ?  212 THR B N   1 
ATOM   5035 C CA  . THR B 2 230 ? 163.769 156.468 158.168 1.00 83.15  ?  212 THR B CA  1 
ATOM   5036 C C   . THR B 2 230 ? 163.787 154.951 158.021 1.00 83.15  ?  212 THR B C   1 
ATOM   5037 O O   . THR B 2 230 ? 164.642 154.282 158.614 1.00 83.15  ?  212 THR B O   1 
ATOM   5038 C CB  . THR B 2 230 ? 162.717 156.885 159.196 1.00 83.15  ?  212 THR B CB  1 
ATOM   5039 O OG1 . THR B 2 230 ? 162.536 158.305 159.145 1.00 83.15  ?  212 THR B OG1 1 
ATOM   5040 C CG2 . THR B 2 230 ? 163.155 156.490 160.598 1.00 83.15  ?  212 THR B CG2 1 
ATOM   5041 N N   . HIS B 2 231 ? 162.853 154.386 157.253 1.00 76.27  ?  213 HIS B N   1 
ATOM   5042 C CA  . HIS B 2 231 ? 162.769 152.935 157.136 1.00 76.27  ?  213 HIS B CA  1 
ATOM   5043 C C   . HIS B 2 231 ? 163.904 152.345 156.310 1.00 76.27  ?  213 HIS B C   1 
ATOM   5044 O O   . HIS B 2 231 ? 164.202 151.155 156.455 1.00 76.27  ?  213 HIS B O   1 
ATOM   5045 C CB  . HIS B 2 231 ? 161.428 152.527 156.528 1.00 76.27  ?  213 HIS B CB  1 
ATOM   5046 C CG  . HIS B 2 231 ? 160.241 153.104 157.232 1.00 76.27  ?  213 HIS B CG  1 
ATOM   5047 N ND1 . HIS B 2 231 ? 159.757 154.367 156.964 1.00 76.27  ?  213 HIS B ND1 1 
ATOM   5048 C CD2 . HIS B 2 231 ? 159.434 152.587 158.187 1.00 76.27  ?  213 HIS B CD2 1 
ATOM   5049 C CE1 . HIS B 2 231 ? 158.706 154.604 157.727 1.00 76.27  ?  213 HIS B CE1 1 
ATOM   5050 N NE2 . HIS B 2 231 ? 158.488 153.540 158.479 1.00 76.27  ?  213 HIS B NE2 1 
ATOM   5051 N N   . PHE B 2 232 ? 164.537 153.136 155.452 1.00 77.70  ?  214 PHE B N   1 
ATOM   5052 C CA  . PHE B 2 232 ? 165.627 152.645 154.610 1.00 77.70  ?  214 PHE B CA  1 
ATOM   5053 C C   . PHE B 2 232 ? 166.984 153.010 155.207 1.00 77.70  ?  214 PHE B C   1 
ATOM   5054 O O   . PHE B 2 232 ? 167.801 153.696 154.594 1.00 77.70  ?  214 PHE B O   1 
ATOM   5055 C CB  . PHE B 2 232 ? 165.481 153.191 153.195 1.00 77.70  ?  214 PHE B CB  1 
ATOM   5056 C CG  . PHE B 2 232 ? 164.247 152.720 152.495 1.00 77.70  ?  214 PHE B CG  1 
ATOM   5057 C CD1 . PHE B 2 232 ? 164.179 151.437 151.982 1.00 77.70  ?  214 PHE B CD1 1 
ATOM   5058 C CD2 . PHE B 2 232 ? 163.155 153.556 152.355 1.00 77.70  ?  214 PHE B CD2 1 
ATOM   5059 C CE1 . PHE B 2 232 ? 163.046 150.997 151.339 1.00 77.70  ?  214 PHE B CE1 1 
ATOM   5060 C CE2 . PHE B 2 232 ? 162.018 153.123 151.713 1.00 77.70  ?  214 PHE B CE2 1 
ATOM   5061 C CZ  . PHE B 2 232 ? 161.964 151.841 151.204 1.00 77.70  ?  214 PHE B CZ  1 
ATOM   5062 N N   . GLU B 2 233 ? 167.220 152.538 156.430 1.00 85.34  ?  215 GLU B N   1 
ATOM   5063 C CA  . GLU B 2 233 ? 168.525 152.692 157.061 1.00 85.34  ?  215 GLU B CA  1 
ATOM   5064 C C   . GLU B 2 233 ? 169.071 151.346 157.516 1.00 85.34  ?  215 GLU B C   1 
ATOM   5065 O O   . GLU B 2 233 ? 170.277 151.096 157.431 1.00 85.34  ?  215 GLU B O   1 
ATOM   5066 C CB  . GLU B 2 233 ? 168.456 153.662 158.249 1.00 85.34  ?  215 GLU B CB  1 
ATOM   5067 C CG  . GLU B 2 233 ? 167.804 155.019 157.960 1.00 85.34  ?  215 GLU B CG  1 
ATOM   5068 C CD  . GLU B 2 233 ? 168.726 156.021 157.269 1.00 85.34  ?  215 GLU B CD  1 
ATOM   5069 O OE1 . GLU B 2 233 ? 169.848 155.654 156.859 1.00 85.34  ?  215 GLU B OE1 1 
ATOM   5070 O OE2 . GLU B 2 233 ? 168.320 157.194 157.138 1.00 85.34  -1 215 GLU B OE2 1 
ATOM   5071 N N   . ASN B 2 234 ? 168.190 150.472 157.991 1.00 81.93  ?  216 ASN B N   1 
ATOM   5072 C CA  . ASN B 2 234 ? 168.563 149.173 158.537 1.00 81.93  ?  216 ASN B CA  1 
ATOM   5073 C C   . ASN B 2 234 ? 167.777 148.075 157.830 1.00 81.93  ?  216 ASN B C   1 
ATOM   5074 O O   . ASN B 2 234 ? 167.094 147.251 158.442 1.00 81.93  ?  216 ASN B O   1 
ATOM   5075 C CB  . ASN B 2 234 ? 168.351 149.154 160.051 1.00 81.93  ?  216 ASN B CB  1 
ATOM   5076 C CG  . ASN B 2 234 ? 168.983 147.946 160.723 1.00 81.93  ?  216 ASN B CG  1 
ATOM   5077 O OD1 . ASN B 2 234 ? 168.536 147.509 161.783 1.00 81.93  ?  216 ASN B OD1 1 
ATOM   5078 N ND2 . ASN B 2 234 ? 170.022 147.400 160.104 1.00 81.93  ?  216 ASN B ND2 1 
ATOM   5079 N N   . SER B 2 235 ? 167.836 148.084 156.502 1.00 77.52  ?  217 SER B N   1 
ATOM   5080 C CA  . SER B 2 235 ? 167.156 147.071 155.714 1.00 77.52  ?  217 SER B CA  1 
ATOM   5081 C C   . SER B 2 235 ? 167.896 145.738 155.809 1.00 77.52  ?  217 SER B C   1 
ATOM   5082 O O   . SER B 2 235 ? 168.991 145.640 156.374 1.00 77.52  ?  217 SER B O   1 
ATOM   5083 C CB  . SER B 2 235 ? 167.042 147.514 154.258 1.00 77.52  ?  217 SER B CB  1 
ATOM   5084 O OG  . SER B 2 235 ? 166.248 148.680 154.147 1.00 77.52  ?  217 SER B OG  1 
ATOM   5085 N N   . PHE B 2 236 ? 167.262 144.705 155.242 1.00 73.39  ?  218 PHE B N   1 
ATOM   5086 C CA  . PHE B 2 236 ? 167.718 143.308 155.274 1.00 73.39  ?  218 PHE B CA  1 
ATOM   5087 C C   . PHE B 2 236 ? 167.896 142.786 156.698 1.00 73.39  ?  218 PHE B C   1 
ATOM   5088 O O   . PHE B 2 236 ? 168.725 141.909 156.947 1.00 73.39  ?  218 PHE B O   1 
ATOM   5089 C CB  . PHE B 2 236 ? 169.008 143.101 154.472 1.00 73.39  ?  218 PHE B CB  1 
ATOM   5090 C CG  . PHE B 2 236 ? 168.880 143.435 153.020 1.00 73.39  ?  218 PHE B CG  1 
ATOM   5091 C CD1 . PHE B 2 236 ? 168.347 142.518 152.131 1.00 73.39  ?  218 PHE B CD1 1 
ATOM   5092 C CD2 . PHE B 2 236 ? 169.305 144.662 152.540 1.00 73.39  ?  218 PHE B CD2 1 
ATOM   5093 C CE1 . PHE B 2 236 ? 168.232 142.822 150.792 1.00 73.39  ?  218 PHE B CE1 1 
ATOM   5094 C CE2 . PHE B 2 236 ? 169.192 144.972 151.202 1.00 73.39  ?  218 PHE B CE2 1 
ATOM   5095 C CZ  . PHE B 2 236 ? 168.654 144.051 150.328 1.00 73.39  ?  218 PHE B CZ  1 
ATOM   5096 N N   . GLU B 2 237 ? 167.122 143.308 157.643 1.00 76.05  ?  219 GLU B N   1 
ATOM   5097 C CA  . GLU B 2 237 ? 167.127 142.825 159.014 1.00 76.05  ?  219 GLU B CA  1 
ATOM   5098 C C   . GLU B 2 237 ? 165.815 142.098 159.260 1.00 76.05  ?  219 GLU B C   1 
ATOM   5099 O O   . GLU B 2 237 ? 164.742 142.604 158.919 1.00 76.05  ?  219 GLU B O   1 
ATOM   5100 C CB  . GLU B 2 237 ? 167.313 143.974 160.013 1.00 76.05  ?  219 GLU B CB  1 
ATOM   5101 C CG  . GLU B 2 237 ? 167.694 143.538 161.424 1.00 76.05  ?  219 GLU B CG  1 
ATOM   5102 C CD  . GLU B 2 237 ? 166.497 143.236 162.304 1.00 76.05  ?  219 GLU B CD  1 
ATOM   5103 O OE1 . GLU B 2 237 ? 165.434 143.859 162.100 1.00 76.05  ?  219 GLU B OE1 1 
ATOM   5104 O OE2 . GLU B 2 237 ? 166.617 142.370 163.197 1.00 76.05  -1 219 GLU B OE2 1 
ATOM   5105 N N   . GLY B 2 238 ? 165.904 140.911 159.847 1.00 73.27  ?  220 GLY B N   1 
ATOM   5106 C CA  . GLY B 2 238 ? 164.739 140.065 159.965 1.00 73.27  ?  220 GLY B CA  1 
ATOM   5107 C C   . GLY B 2 238 ? 164.324 139.390 158.680 1.00 73.27  ?  220 GLY B C   1 
ATOM   5108 O O   . GLY B 2 238 ? 163.173 138.953 158.573 1.00 73.27  ?  220 GLY B O   1 
ATOM   5109 N N   . SER B 2 239 ? 165.222 139.295 157.704 1.00 71.71  ?  221 SER B N   1 
ATOM   5110 C CA  . SER B 2 239 ? 164.891 138.700 156.418 1.00 71.71  ?  221 SER B CA  1 
ATOM   5111 C C   . SER B 2 239 ? 164.747 137.192 156.545 1.00 71.71  ?  221 SER B C   1 
ATOM   5112 O O   . SER B 2 239 ? 165.409 136.554 157.367 1.00 71.71  ?  221 SER B O   1 
ATOM   5113 C CB  . SER B 2 239 ? 165.969 139.028 155.390 1.00 71.71  ?  221 SER B CB  1 
ATOM   5114 O OG  . SER B 2 239 ? 166.071 140.421 155.186 1.00 71.71  ?  221 SER B OG  1 
ATOM   5115 N N   . SER B 2 240 ? 163.873 136.622 155.723 1.00 72.83  ?  222 SER B N   1 
ATOM   5116 C CA  . SER B 2 240 ? 163.630 135.183 155.721 1.00 72.83  ?  222 SER B CA  1 
ATOM   5117 C C   . SER B 2 240 ? 164.337 134.581 154.515 1.00 72.83  ?  222 SER B C   1 
ATOM   5118 O O   . SER B 2 240 ? 163.778 134.525 153.419 1.00 72.83  ?  222 SER B O   1 
ATOM   5119 C CB  . SER B 2 240 ? 162.136 134.891 155.697 1.00 72.83  ?  222 SER B CB  1 
ATOM   5120 O OG  . SER B 2 240 ? 161.898 133.497 155.675 1.00 72.83  ?  222 SER B OG  1 
ATOM   5121 N N   . PHE B 2 241 ? 165.568 134.123 154.717 1.00 72.69  ?  223 PHE B N   1 
ATOM   5122 C CA  . PHE B 2 241 ? 166.362 133.544 153.634 1.00 72.69  ?  223 PHE B CA  1 
ATOM   5123 C C   . PHE B 2 241 ? 166.159 132.036 153.530 1.00 72.69  ?  223 PHE B C   1 
ATOM   5124 O O   . PHE B 2 241 ? 167.113 131.267 153.464 1.00 72.69  ?  223 PHE B O   1 
ATOM   5125 C CB  . PHE B 2 241 ? 167.834 133.876 153.841 1.00 72.69  ?  223 PHE B CB  1 
ATOM   5126 C CG  . PHE B 2 241 ? 168.180 135.312 153.584 1.00 72.69  ?  223 PHE B CG  1 
ATOM   5127 C CD1 . PHE B 2 241 ? 167.985 135.875 152.335 1.00 72.69  ?  223 PHE B CD1 1 
ATOM   5128 C CD2 . PHE B 2 241 ? 168.726 136.093 154.589 1.00 72.69  ?  223 PHE B CD2 1 
ATOM   5129 C CE1 . PHE B 2 241 ? 168.315 137.195 152.097 1.00 72.69  ?  223 PHE B CE1 1 
ATOM   5130 C CE2 . PHE B 2 241 ? 169.060 137.413 154.357 1.00 72.69  ?  223 PHE B CE2 1 
ATOM   5131 C CZ  . PHE B 2 241 ? 168.853 137.964 153.110 1.00 72.69  ?  223 PHE B CZ  1 
ATOM   5132 N N   . ALA B 2 242 ? 164.906 131.604 153.495 1.00 72.78  ?  224 ALA B N   1 
ATOM   5133 C CA  . ALA B 2 242 ? 164.560 130.202 153.330 1.00 72.78  ?  224 ALA B CA  1 
ATOM   5134 C C   . ALA B 2 242 ? 164.084 129.952 151.907 1.00 72.78  ?  224 ALA B C   1 
ATOM   5135 O O   . ALA B 2 242 ? 163.753 130.881 151.169 1.00 72.78  ?  224 ALA B O   1 
ATOM   5136 C CB  . ALA B 2 242 ? 163.479 129.784 154.330 1.00 72.78  ?  224 ALA B CB  1 
ATOM   5137 N N   . VAL B 2 243 ? 164.057 128.676 151.522 1.00 71.77  ?  225 VAL B N   1 
ATOM   5138 C CA  . VAL B 2 243 ? 163.600 128.338 150.179 1.00 71.77  ?  225 VAL B CA  1 
ATOM   5139 C C   . VAL B 2 243 ? 162.090 128.491 150.067 1.00 71.77  ?  225 VAL B C   1 
ATOM   5140 O O   . VAL B 2 243 ? 161.589 129.075 149.098 1.00 71.77  ?  225 VAL B O   1 
ATOM   5141 C CB  . VAL B 2 243 ? 164.057 126.920 149.803 1.00 71.77  ?  225 VAL B CB  1 
ATOM   5142 C CG1 . VAL B 2 243 ? 163.859 126.678 148.319 1.00 71.77  ?  225 VAL B CG1 1 
ATOM   5143 C CG2 . VAL B 2 243 ? 165.512 126.729 150.178 1.00 71.77  ?  225 VAL B CG2 1 
ATOM   5144 N N   . GLY B 2 244 ? 161.344 128.002 151.057 1.00 71.46  ?  226 GLY B N   1 
ATOM   5145 C CA  . GLY B 2 244 ? 159.896 128.063 151.035 1.00 71.46  ?  226 GLY B CA  1 
ATOM   5146 C C   . GLY B 2 244 ? 159.299 129.444 151.169 1.00 71.46  ?  226 GLY B C   1 
ATOM   5147 O O   . GLY B 2 244 ? 158.123 129.629 150.841 1.00 71.46  ?  226 GLY B O   1 
ATOM   5148 N N   . ASP B 2 245 ? 160.074 130.418 151.639 1.00 70.03  ?  227 ASP B N   1 
ATOM   5149 C CA  . ASP B 2 245 ? 159.621 131.798 151.734 1.00 70.03  ?  227 ASP B CA  1 
ATOM   5150 C C   . ASP B 2 245 ? 159.994 132.625 150.514 1.00 70.03  ?  227 ASP B C   1 
ATOM   5151 O O   . ASP B 2 245 ? 159.159 133.385 150.011 1.00 70.03  ?  227 ASP B O   1 
ATOM   5152 C CB  . ASP B 2 245 ? 160.196 132.453 152.991 1.00 70.03  ?  227 ASP B CB  1 
ATOM   5153 C CG  . ASP B 2 245 ? 159.468 132.034 154.247 1.00 70.03  ?  227 ASP B CG  1 
ATOM   5154 O OD1 . ASP B 2 245 ? 158.615 131.127 154.166 1.00 70.03  ?  227 ASP B OD1 1 
ATOM   5155 O OD2 . ASP B 2 245 ? 159.744 132.610 155.317 1.00 70.03  -1 227 ASP B OD2 1 
ATOM   5156 N N   . ILE B 2 246 ? 161.228 132.483 150.026 1.00 65.65  ?  228 ILE B N   1 
ATOM   5157 C CA  . ILE B 2 246 ? 161.658 133.192 148.826 1.00 65.65  ?  228 ILE B CA  1 
ATOM   5158 C C   . ILE B 2 246 ? 160.900 132.679 147.605 1.00 65.65  ?  228 ILE B C   1 
ATOM   5159 O O   . ILE B 2 246 ? 160.525 133.460 146.721 1.00 65.65  ?  228 ILE B O   1 
ATOM   5160 C CB  . ILE B 2 246 ? 163.188 133.070 148.672 1.00 65.65  ?  228 ILE B CB  1 
ATOM   5161 C CG1 . ILE B 2 246 ? 163.884 133.852 149.785 1.00 65.65  ?  228 ILE B CG1 1 
ATOM   5162 C CG2 . ILE B 2 246 ? 163.675 133.591 147.332 1.00 65.65  ?  228 ILE B CG2 1 
ATOM   5163 C CD1 . ILE B 2 246 ? 165.384 133.719 149.780 1.00 65.65  ?  228 ILE B CD1 1 
ATOM   5164 N N   . ALA B 2 247 ? 160.595 131.377 147.575 1.00 64.18  ?  229 ALA B N   1 
ATOM   5165 C CA  . ALA B 2 247 ? 159.799 130.819 146.485 1.00 64.18  ?  229 ALA B CA  1 
ATOM   5166 C C   . ALA B 2 247 ? 158.373 131.359 146.479 1.00 64.18  ?  229 ALA B C   1 
ATOM   5167 O O   . ALA B 2 247 ? 157.848 131.698 145.413 1.00 64.18  ?  229 ALA B O   1 
ATOM   5168 C CB  . ALA B 2 247 ? 159.786 129.295 146.576 1.00 64.18  ?  229 ALA B CB  1 
ATOM   5169 N N   . LEU B 2 248 ? 157.746 131.480 147.649 1.00 64.41  ?  230 LEU B N   1 
ATOM   5170 C CA  . LEU B 2 248 ? 156.388 132.007 147.709 1.00 64.41  ?  230 LEU B CA  1 
ATOM   5171 C C   . LEU B 2 248 ? 156.342 133.506 147.439 1.00 64.41  ?  230 LEU B C   1 
ATOM   5172 O O   . LEU B 2 248 ? 155.383 133.992 146.825 1.00 64.41  ?  230 LEU B O   1 
ATOM   5173 C CB  . LEU B 2 248 ? 155.768 131.690 149.067 1.00 64.41  ?  230 LEU B CB  1 
ATOM   5174 C CG  . LEU B 2 248 ? 155.103 130.316 149.146 1.00 64.41  ?  230 LEU B CG  1 
ATOM   5175 C CD1 . LEU B 2 248 ? 154.725 129.983 150.572 1.00 64.41  ?  230 LEU B CD1 1 
ATOM   5176 C CD2 . LEU B 2 248 ? 153.885 130.276 148.249 1.00 64.41  ?  230 LEU B CD2 1 
ATOM   5177 N N   . ALA B 2 249 ? 157.379 134.240 147.853 1.00 61.77  ?  231 ALA B N   1 
ATOM   5178 C CA  . ALA B 2 249 ? 157.457 135.660 147.529 1.00 61.77  ?  231 ALA B CA  1 
ATOM   5179 C C   . ALA B 2 249 ? 157.657 135.875 146.035 1.00 61.77  ?  231 ALA B C   1 
ATOM   5180 O O   . ALA B 2 249 ? 157.062 136.790 145.452 1.00 61.77  ?  231 ALA B O   1 
ATOM   5181 C CB  . ALA B 2 249 ? 158.582 136.317 148.324 1.00 61.77  ?  231 ALA B CB  1 
ATOM   5182 N N   . LEU B 2 250 ? 158.467 135.025 145.394 1.00 61.06  ?  232 LEU B N   1 
ATOM   5183 C CA  . LEU B 2 250 ? 158.655 135.119 143.949 1.00 61.06  ?  232 LEU B CA  1 
ATOM   5184 C C   . LEU B 2 250 ? 157.387 134.734 143.200 1.00 61.06  ?  232 LEU B C   1 
ATOM   5185 O O   . LEU B 2 250 ? 157.074 135.325 142.163 1.00 61.06  ?  232 LEU B O   1 
ATOM   5186 C CB  . LEU B 2 250 ? 159.821 134.236 143.513 1.00 61.06  ?  232 LEU B CB  1 
ATOM   5187 C CG  . LEU B 2 250 ? 160.375 134.525 142.121 1.00 61.06  ?  232 LEU B CG  1 
ATOM   5188 C CD1 . LEU B 2 250 ? 160.869 135.955 142.032 1.00 61.06  ?  232 LEU B CD1 1 
ATOM   5189 C CD2 . LEU B 2 250 ? 161.484 133.552 141.781 1.00 61.06  ?  232 LEU B CD2 1 
ATOM   5190 N N   . TYR B 2 251 ? 156.638 133.762 143.728 1.00 60.91  ?  233 TYR B N   1 
ATOM   5191 C CA  . TYR B 2 251 ? 155.348 133.387 143.154 1.00 60.91  ?  233 TYR B CA  1 
ATOM   5192 C C   . TYR B 2 251 ? 154.349 134.539 143.218 1.00 60.91  ?  233 TYR B C   1 
ATOM   5193 O O   . TYR B 2 251 ? 153.653 134.824 142.232 1.00 60.91  ?  233 TYR B O   1 
ATOM   5194 C CB  . TYR B 2 251 ? 154.817 132.162 143.895 1.00 60.91  ?  233 TYR B CB  1 
ATOM   5195 C CG  . TYR B 2 251 ? 153.559 131.551 143.336 1.00 60.91  ?  233 TYR B CG  1 
ATOM   5196 C CD1 . TYR B 2 251 ? 153.599 130.744 142.211 1.00 60.91  ?  233 TYR B CD1 1 
ATOM   5197 C CD2 . TYR B 2 251 ? 152.335 131.756 143.955 1.00 60.91  ?  233 TYR B CD2 1 
ATOM   5198 C CE1 . TYR B 2 251 ? 152.453 130.175 141.705 1.00 60.91  ?  233 TYR B CE1 1 
ATOM   5199 C CE2 . TYR B 2 251 ? 151.184 131.194 143.457 1.00 60.91  ?  233 TYR B CE2 1 
ATOM   5200 C CZ  . TYR B 2 251 ? 151.250 130.399 142.335 1.00 60.91  ?  233 TYR B CZ  1 
ATOM   5201 O OH  . TYR B 2 251 ? 150.104 129.834 141.829 1.00 60.91  ?  233 TYR B OH  1 
ATOM   5202 N N   . SER B 2 252 ? 154.286 135.226 144.363 1.00 60.77  ?  234 SER B N   1 
ATOM   5203 C CA  . SER B 2 252 ? 153.367 136.352 144.507 1.00 60.77  ?  234 SER B CA  1 
ATOM   5204 C C   . SER B 2 252 ? 153.790 137.539 143.649 1.00 60.77  ?  234 SER B C   1 
ATOM   5205 O O   . SER B 2 252 ? 152.938 138.239 143.091 1.00 60.77  ?  234 SER B O   1 
ATOM   5206 C CB  . SER B 2 252 ? 153.271 136.764 145.972 1.00 60.77  ?  234 SER B CB  1 
ATOM   5207 O OG  . SER B 2 252 ? 152.709 135.726 146.750 1.00 60.77  ?  234 SER B OG  1 
ATOM   5208 N N   . ALA B 2 253 ? 155.097 137.783 143.531 1.00 59.07  ?  235 ALA B N   1 
ATOM   5209 C CA  . ALA B 2 253 ? 155.566 138.888 142.703 1.00 59.07  ?  235 ALA B CA  1 
ATOM   5210 C C   . ALA B 2 253 ? 155.403 138.588 141.224 1.00 59.07  ?  235 ALA B C   1 
ATOM   5211 O O   . ALA B 2 253 ? 155.242 139.510 140.420 1.00 59.07  ?  235 ALA B O   1 
ATOM   5212 C CB  . ALA B 2 253 ? 157.030 139.196 143.007 1.00 59.07  ?  235 ALA B CB  1 
ATOM   5213 N N   . LEU B 2 254 ? 155.441 137.315 140.847 1.00 58.36  ?  236 LEU B N   1 
ATOM   5214 C CA  . LEU B 2 254 ? 155.325 136.936 139.451 1.00 58.36  ?  236 LEU B CA  1 
ATOM   5215 C C   . LEU B 2 254 ? 153.875 136.803 139.007 1.00 58.36  ?  236 LEU B C   1 
ATOM   5216 O O   . LEU B 2 254 ? 153.604 136.881 137.805 1.00 58.36  ?  236 LEU B O   1 
ATOM   5217 C CB  . LEU B 2 254 ? 156.098 135.636 139.239 1.00 58.36  ?  236 LEU B CB  1 
ATOM   5218 C CG  . LEU B 2 254 ? 156.487 135.158 137.853 1.00 58.36  ?  236 LEU B CG  1 
ATOM   5219 C CD1 . LEU B 2 254 ? 157.368 136.193 137.205 1.00 58.36  ?  236 LEU B CD1 1 
ATOM   5220 C CD2 . LEU B 2 254 ? 157.256 133.878 138.018 1.00 58.36  ?  236 LEU B CD2 1 
ATOM   5221 N N   . PHE B 2 255 ? 152.938 136.616 139.941 1.00 59.71  ?  237 PHE B N   1 
ATOM   5222 C CA  . PHE B 2 255 ? 151.528 136.773 139.597 1.00 59.71  ?  237 PHE B CA  1 
ATOM   5223 C C   . PHE B 2 255 ? 151.152 138.222 139.325 1.00 59.71  ?  237 PHE B C   1 
ATOM   5224 O O   . PHE B 2 255 ? 150.186 138.477 138.601 1.00 59.71  ?  237 PHE B O   1 
ATOM   5225 C CB  . PHE B 2 255 ? 150.632 136.235 140.711 1.00 59.71  ?  237 PHE B CB  1 
ATOM   5226 C CG  . PHE B 2 255 ? 150.075 134.875 140.437 1.00 59.71  ?  237 PHE B CG  1 
ATOM   5227 C CD1 . PHE B 2 255 ? 150.909 133.817 140.133 1.00 59.71  ?  237 PHE B CD1 1 
ATOM   5228 C CD2 . PHE B 2 255 ? 148.707 134.654 140.492 1.00 59.71  ?  237 PHE B CD2 1 
ATOM   5229 C CE1 . PHE B 2 255 ? 150.391 132.567 139.882 1.00 59.71  ?  237 PHE B CE1 1 
ATOM   5230 C CE2 . PHE B 2 255 ? 148.183 133.402 140.240 1.00 59.71  ?  237 PHE B CE2 1 
ATOM   5231 C CZ  . PHE B 2 255 ? 149.026 132.358 139.936 1.00 59.71  ?  237 PHE B CZ  1 
ATOM   5232 N N   . SER B 2 256 ? 151.878 139.178 139.905 1.00 56.27  ?  238 SER B N   1 
ATOM   5233 C CA  . SER B 2 256 ? 151.516 140.582 139.756 1.00 56.27  ?  238 SER B CA  1 
ATOM   5234 C C   . SER B 2 256 ? 151.888 141.139 138.391 1.00 56.27  ?  238 SER B C   1 
ATOM   5235 O O   . SER B 2 256 ? 151.269 142.108 137.943 1.00 56.27  ?  238 SER B O   1 
ATOM   5236 C CB  . SER B 2 256 ? 152.182 141.410 140.849 1.00 56.27  ?  238 SER B CB  1 
ATOM   5237 O OG  . SER B 2 256 ? 151.722 141.019 142.128 1.00 56.27  ?  238 SER B OG  1 
ATOM   5238 N N   . TYR B 2 257 ? 152.875 140.553 137.725 1.00 52.49  ?  239 TYR B N   1 
ATOM   5239 C CA  . TYR B 2 257 ? 153.276 140.970 136.393 1.00 52.49  ?  239 TYR B CA  1 
ATOM   5240 C C   . TYR B 2 257 ? 152.496 140.258 135.297 1.00 52.49  ?  239 TYR B C   1 
ATOM   5241 O O   . TYR B 2 257 ? 152.876 140.350 134.129 1.00 52.49  ?  239 TYR B O   1 
ATOM   5242 C CB  . TYR B 2 257 ? 154.770 140.724 136.192 1.00 52.49  ?  239 TYR B CB  1 
ATOM   5243 C CG  . TYR B 2 257 ? 155.680 141.724 136.859 1.00 52.49  ?  239 TYR B CG  1 
ATOM   5244 C CD1 . TYR B 2 257 ? 155.976 142.934 136.250 1.00 52.49  ?  239 TYR B CD1 1 
ATOM   5245 C CD2 . TYR B 2 257 ? 156.264 141.447 138.086 1.00 52.49  ?  239 TYR B CD2 1 
ATOM   5246 C CE1 . TYR B 2 257 ? 156.815 143.848 136.853 1.00 52.49  ?  239 TYR B CE1 1 
ATOM   5247 C CE2 . TYR B 2 257 ? 157.101 142.354 138.697 1.00 52.49  ?  239 TYR B CE2 1 
ATOM   5248 C CZ  . TYR B 2 257 ? 157.374 143.551 138.075 1.00 52.49  ?  239 TYR B CZ  1 
ATOM   5249 O OH  . TYR B 2 257 ? 158.210 144.456 138.681 1.00 52.49  ?  239 TYR B OH  1 
ATOM   5250 N N   . SER B 2 258 ? 151.427 139.551 135.649 1.00 54.27  ?  240 SER B N   1 
ATOM   5251 C CA  . SER B 2 258 ? 150.656 138.800 134.671 1.00 54.27  ?  240 SER B CA  1 
ATOM   5252 C C   . SER B 2 258 ? 149.901 139.731 133.732 1.00 54.27  ?  240 SER B C   1 
ATOM   5253 O O   . SER B 2 258 ? 149.450 140.808 134.126 1.00 54.27  ?  240 SER B O   1 
ATOM   5254 C CB  . SER B 2 258 ? 149.674 137.874 135.379 1.00 54.27  ?  240 SER B CB  1 
ATOM   5255 O OG  . SER B 2 258 ? 148.860 137.193 134.446 1.00 54.27  ?  240 SER B OG  1 
ATOM   5256 N N   . GLY B 2 259 ? 149.775 139.311 132.479 1.00 49.54  ?  241 GLY B N   1 
ATOM   5257 C CA  . GLY B 2 259 ? 149.069 140.079 131.481 1.00 49.54  ?  241 GLY B CA  1 
ATOM   5258 C C   . GLY B 2 259 ? 149.920 140.680 130.386 1.00 49.54  ?  241 GLY B C   1 
ATOM   5259 O O   . GLY B 2 259 ? 149.437 141.568 129.678 1.00 49.54  ?  241 GLY B O   1 
ATOM   5260 N N   . TRP B 2 260 ? 151.159 140.225 130.205 1.00 49.34  ?  242 TRP B N   1 
ATOM   5261 C CA  . TRP B 2 260 ? 152.008 140.790 129.162 1.00 49.34  ?  242 TRP B CA  1 
ATOM   5262 C C   . TRP B 2 260 ? 151.746 140.194 127.787 1.00 49.34  ?  242 TRP B C   1 
ATOM   5263 O O   . TRP B 2 260 ? 152.472 140.518 126.844 1.00 49.34  ?  242 TRP B O   1 
ATOM   5264 C CB  . TRP B 2 260 ? 153.492 140.620 129.513 1.00 49.34  ?  242 TRP B CB  1 
ATOM   5265 C CG  . TRP B 2 260 ? 153.845 139.338 130.191 1.00 49.34  ?  242 TRP B CG  1 
ATOM   5266 C CD1 . TRP B 2 260 ? 154.044 139.150 131.521 1.00 49.34  ?  242 TRP B CD1 1 
ATOM   5267 C CD2 . TRP B 2 260 ? 154.063 138.067 129.569 1.00 49.34  ?  242 TRP B CD2 1 
ATOM   5268 N NE1 . TRP B 2 260 ? 154.358 137.841 131.773 1.00 49.34  ?  242 TRP B NE1 1 
ATOM   5269 C CE2 . TRP B 2 260 ? 154.371 137.154 130.590 1.00 49.34  ?  242 TRP B CE2 1 
ATOM   5270 C CE3 . TRP B 2 260 ? 154.017 137.612 128.250 1.00 49.34  ?  242 TRP B CE3 1 
ATOM   5271 C CZ2 . TRP B 2 260 ? 154.639 135.816 130.336 1.00 49.34  ?  242 TRP B CZ2 1 
ATOM   5272 C CZ3 . TRP B 2 260 ? 154.281 136.286 128.002 1.00 49.34  ?  242 TRP B CZ3 1 
ATOM   5273 C CH2 . TRP B 2 260 ? 154.586 135.401 129.036 1.00 49.34  ?  242 TRP B CH2 1 
ATOM   5274 N N   . ASP B 2 261 ? 150.731 139.344 127.643 1.00 48.62  ?  243 ASP B N   1 
ATOM   5275 C CA  . ASP B 2 261 ? 150.435 138.681 126.382 1.00 48.62  ?  243 ASP B CA  1 
ATOM   5276 C C   . ASP B 2 261 ? 149.132 139.160 125.760 1.00 48.62  ?  243 ASP B C   1 
ATOM   5277 O O   . ASP B 2 261 ? 148.525 138.429 124.976 1.00 48.62  ?  243 ASP B O   1 
ATOM   5278 C CB  . ASP B 2 261 ? 150.393 137.170 126.589 1.00 48.62  ?  243 ASP B CB  1 
ATOM   5279 C CG  . ASP B 2 261 ? 149.298 136.738 127.533 1.00 48.62  ?  243 ASP B CG  1 
ATOM   5280 O OD1 . ASP B 2 261 ? 148.950 137.511 128.446 1.00 48.62  ?  243 ASP B OD1 1 
ATOM   5281 O OD2 . ASP B 2 261 ? 148.789 135.613 127.364 1.00 48.62  -1 243 ASP B OD2 1 
ATOM   5282 N N   . THR B 2 262 ? 148.697 140.379 126.081 1.00 46.73  ?  244 THR B N   1 
ATOM   5283 C CA  . THR B 2 262 ? 147.398 140.851 125.610 1.00 46.73  ?  244 THR B CA  1 
ATOM   5284 C C   . THR B 2 262 ? 147.437 141.220 124.132 1.00 46.73  ?  244 THR B C   1 
ATOM   5285 O O   . THR B 2 262 ? 146.466 140.983 123.405 1.00 46.73  ?  244 THR B O   1 
ATOM   5286 C CB  . THR B 2 262 ? 146.941 142.042 126.452 1.00 46.73  ?  244 THR B CB  1 
ATOM   5287 O OG1 . THR B 2 262 ? 147.129 141.741 127.838 1.00 46.73  ?  244 THR B OG1 1 
ATOM   5288 C CG2 . THR B 2 262 ? 145.472 142.344 126.214 1.00 46.73  ?  244 THR B CG2 1 
ATOM   5289 N N   . LEU B 2 263 ? 148.553 141.779 123.659 1.00 45.06  ?  245 LEU B N   1 
ATOM   5290 C CA  . LEU B 2 263 ? 148.629 142.186 122.261 1.00 45.06  ?  245 LEU B CA  1 
ATOM   5291 C C   . LEU B 2 263 ? 148.777 141.001 121.317 1.00 45.06  ?  245 LEU B C   1 
ATOM   5292 O O   . LEU B 2 263 ? 148.510 141.137 120.121 1.00 45.06  ?  245 LEU B O   1 
ATOM   5293 C CB  . LEU B 2 263 ? 149.779 143.171 122.054 1.00 45.06  ?  245 LEU B CB  1 
ATOM   5294 C CG  . LEU B 2 263 ? 149.581 144.112 120.867 1.00 45.06  ?  245 LEU B CG  1 
ATOM   5295 C CD1 . LEU B 2 263 ? 148.321 144.925 121.039 1.00 45.06  ?  245 LEU B CD1 1 
ATOM   5296 C CD2 . LEU B 2 263 ? 150.767 144.998 120.658 1.00 45.06  ?  245 LEU B CD2 1 
ATOM   5297 N N   . ASN B 2 264 ? 149.162 139.837 121.825 1.00 45.28  ?  246 ASN B N   1 
ATOM   5298 C CA  . ASN B 2 264 ? 149.263 138.654 120.988 1.00 45.28  ?  246 ASN B CA  1 
ATOM   5299 C C   . ASN B 2 264 ? 147.905 138.066 120.629 1.00 45.28  ?  246 ASN B C   1 
ATOM   5300 O O   . ASN B 2 264 ? 147.832 137.235 119.720 1.00 45.28  ?  246 ASN B O   1 
ATOM   5301 C CB  . ASN B 2 264 ? 150.130 137.606 121.686 1.00 45.28  ?  246 ASN B CB  1 
ATOM   5302 C CG  . ASN B 2 264 ? 151.600 137.926 121.616 1.00 45.28  ?  246 ASN B CG  1 
ATOM   5303 O OD1 . ASN B 2 264 ? 152.111 138.724 122.395 1.00 45.28  ?  246 ASN B OD1 1 
ATOM   5304 N ND2 . ASN B 2 264 ? 152.294 137.299 120.681 1.00 45.28  ?  246 ASN B ND2 1 
ATOM   5305 N N   . TYR B 2 265 ? 146.835 138.476 121.312 1.00 44.64  ?  247 TYR B N   1 
ATOM   5306 C CA  . TYR B 2 265 ? 145.488 138.047 120.963 1.00 44.64  ?  247 TYR B CA  1 
ATOM   5307 C C   . TYR B 2 265 ? 144.912 138.802 119.775 1.00 44.64  ?  247 TYR B C   1 
ATOM   5308 O O   . TYR B 2 265 ? 143.923 138.348 119.196 1.00 44.64  ?  247 TYR B O   1 
ATOM   5309 C CB  . TYR B 2 265 ? 144.539 138.234 122.147 1.00 44.64  ?  247 TYR B CB  1 
ATOM   5310 C CG  . TYR B 2 265 ? 144.701 137.247 123.268 1.00 44.64  ?  247 TYR B CG  1 
ATOM   5311 C CD1 . TYR B 2 265 ? 144.031 136.034 123.253 1.00 44.64  ?  247 TYR B CD1 1 
ATOM   5312 C CD2 . TYR B 2 265 ? 145.509 137.538 124.356 1.00 44.64  ?  247 TYR B CD2 1 
ATOM   5313 C CE1 . TYR B 2 265 ? 144.174 135.132 124.284 1.00 44.64  ?  247 TYR B CE1 1 
ATOM   5314 C CE2 . TYR B 2 265 ? 145.659 136.646 125.389 1.00 44.64  ?  247 TYR B CE2 1 
ATOM   5315 C CZ  . TYR B 2 265 ? 144.989 135.445 125.349 1.00 44.64  ?  247 TYR B CZ  1 
ATOM   5316 O OH  . TYR B 2 265 ? 145.139 134.553 126.381 1.00 44.64  ?  247 TYR B OH  1 
ATOM   5317 N N   . VAL B 2 266 ? 145.475 139.955 119.427 1.00 46.63  ?  248 VAL B N   1 
ATOM   5318 C CA  . VAL B 2 266 ? 144.905 140.824 118.404 1.00 46.63  ?  248 VAL B CA  1 
ATOM   5319 C C   . VAL B 2 266 ? 145.924 141.083 117.302 1.00 46.63  ?  248 VAL B C   1 
ATOM   5320 O O   . VAL B 2 266 ? 145.945 142.168 116.711 1.00 46.63  ?  248 VAL B O   1 
ATOM   5321 C CB  . VAL B 2 266 ? 144.394 142.143 119.016 1.00 46.63  ?  248 VAL B CB  1 
ATOM   5322 C CG1 . VAL B 2 266 ? 143.164 141.891 119.853 1.00 46.63  ?  248 VAL B CG1 1 
ATOM   5323 C CG2 . VAL B 2 266 ? 145.465 142.780 119.881 1.00 46.63  ?  248 VAL B CG2 1 
ATOM   5324 N N   . THR B 2 267 ? 146.762 140.079 117.020 1.00 49.07  ?  249 THR B N   1 
ATOM   5325 C CA  . THR B 2 267 ? 147.902 140.241 116.116 1.00 49.07  ?  249 THR B CA  1 
ATOM   5326 C C   . THR B 2 267 ? 147.478 140.568 114.688 1.00 49.07  ?  249 THR B C   1 
ATOM   5327 O O   . THR B 2 267 ? 148.177 141.310 113.989 1.00 49.07  ?  249 THR B O   1 
ATOM   5328 C CB  . THR B 2 267 ? 148.754 138.973 116.138 1.00 49.07  ?  249 THR B CB  1 
ATOM   5329 O OG1 . THR B 2 267 ? 148.906 138.530 117.489 1.00 49.07  ?  249 THR B OG1 1 
ATOM   5330 C CG2 . THR B 2 267 ? 150.129 139.226 115.554 1.00 49.07  ?  249 THR B CG2 1 
ATOM   5331 N N   . GLU B 2 268 ? 146.322 140.080 114.252 1.00 54.48  ?  250 GLU B N   1 
ATOM   5332 C CA  . GLU B 2 268 ? 145.840 140.358 112.905 1.00 54.48  ?  250 GLU B CA  1 
ATOM   5333 C C   . GLU B 2 268 ? 145.200 141.735 112.761 1.00 54.48  ?  250 GLU B C   1 
ATOM   5334 O O   . GLU B 2 268 ? 144.640 142.023 111.701 1.00 54.48  ?  250 GLU B O   1 
ATOM   5335 C CB  . GLU B 2 268 ? 144.839 139.289 112.472 1.00 54.48  ?  250 GLU B CB  1 
ATOM   5336 C CG  . GLU B 2 268 ? 145.467 137.977 112.070 1.00 54.48  ?  250 GLU B CG  1 
ATOM   5337 C CD  . GLU B 2 268 ? 144.445 136.869 111.962 1.00 54.48  ?  250 GLU B CD  1 
ATOM   5338 O OE1 . GLU B 2 268 ? 143.235 137.170 111.963 1.00 54.48  ?  250 GLU B OE1 1 
ATOM   5339 O OE2 . GLU B 2 268 ? 144.847 135.694 111.882 1.00 54.48  -1 250 GLU B OE2 1 
ATOM   5340 N N   . GLU B 2 269 ? 145.258 142.586 113.784 1.00 54.43  ?  251 GLU B N   1 
ATOM   5341 C CA  . GLU B 2 269 ? 144.696 143.927 113.715 1.00 54.43  ?  251 GLU B CA  1 
ATOM   5342 C C   . GLU B 2 269 ? 145.743 145.013 113.920 1.00 54.43  ?  251 GLU B C   1 
ATOM   5343 O O   . GLU B 2 269 ? 145.387 146.191 113.995 1.00 54.43  ?  251 GLU B O   1 
ATOM   5344 C CB  . GLU B 2 269 ? 143.570 144.087 114.736 1.00 54.43  ?  251 GLU B CB  1 
ATOM   5345 C CG  . GLU B 2 269 ? 142.435 143.103 114.553 1.00 54.43  ?  251 GLU B CG  1 
ATOM   5346 C CD  . GLU B 2 269 ? 141.426 143.161 115.681 1.00 54.43  ?  251 GLU B CD  1 
ATOM   5347 O OE1 . GLU B 2 269 ? 141.384 144.187 116.389 1.00 54.43  ?  251 GLU B OE1 1 
ATOM   5348 O OE2 . GLU B 2 269 ? 140.677 142.179 115.861 1.00 54.43  -1 251 GLU B OE2 1 
ATOM   5349 N N   . ILE B 2 270 ? 147.006 144.656 114.000 1.00 52.84  ?  252 ILE B N   1 
ATOM   5350 C CA  . ILE B 2 270 ? 148.099 145.607 114.158 1.00 52.84  ?  252 ILE B CA  1 
ATOM   5351 C C   . ILE B 2 270 ? 148.604 146.005 112.777 1.00 52.84  ?  252 ILE B C   1 
ATOM   5352 O O   . ILE B 2 270 ? 148.598 145.196 111.844 1.00 52.84  ?  252 ILE B O   1 
ATOM   5353 C CB  . ILE B 2 270 ? 149.208 144.985 115.034 1.00 52.84  ?  252 ILE B CB  1 
ATOM   5354 C CG1 . ILE B 2 270 ? 148.580 144.283 116.236 1.00 52.84  ?  252 ILE B CG1 1 
ATOM   5355 C CG2 . ILE B 2 270 ? 150.181 146.030 115.518 1.00 52.84  ?  252 ILE B CG2 1 
ATOM   5356 C CD1 . ILE B 2 270 ? 149.561 143.527 117.093 1.00 52.84  ?  252 ILE B CD1 1 
ATOM   5357 N N   . LYS B 2 271 ? 149.026 147.266 112.636 1.00 57.30  ?  253 LYS B N   1 
ATOM   5358 C CA  . LYS B 2 271 ? 149.458 147.831 111.359 1.00 57.30  ?  253 LYS B CA  1 
ATOM   5359 C C   . LYS B 2 271 ? 150.689 147.141 110.778 1.00 57.30  ?  253 LYS B C   1 
ATOM   5360 O O   . LYS B 2 271 ? 150.612 146.524 109.712 1.00 57.30  ?  253 LYS B O   1 
ATOM   5361 C CB  . LYS B 2 271 ? 149.750 149.323 111.513 1.00 57.30  ?  253 LYS B CB  1 
ATOM   5362 C CG  . LYS B 2 271 ? 148.599 150.136 112.056 1.00 57.30  ?  253 LYS B CG  1 
ATOM   5363 C CD  . LYS B 2 271 ? 147.535 150.367 111.013 1.00 57.30  ?  253 LYS B CD  1 
ATOM   5364 C CE  . LYS B 2 271 ? 146.466 151.310 111.536 1.00 57.30  ?  253 LYS B CE  1 
ATOM   5365 N NZ  . LYS B 2 271 ? 147.028 152.619 111.961 1.00 57.30  1  253 LYS B NZ  1 
ATOM   5366 N N   . ASN B 2 272 ? 151.828 147.247 111.460 1.00 59.13  ?  254 ASN B N   1 
ATOM   5367 C CA  . ASN B 2 272 ? 153.044 146.535 111.077 1.00 59.13  ?  254 ASN B CA  1 
ATOM   5368 C C   . ASN B 2 272 ? 153.356 145.535 112.176 1.00 59.13  ?  254 ASN B C   1 
ATOM   5369 O O   . ASN B 2 272 ? 154.084 145.862 113.123 1.00 59.13  ?  254 ASN B O   1 
ATOM   5370 C CB  . ASN B 2 272 ? 154.218 147.494 110.875 1.00 59.13  ?  254 ASN B CB  1 
ATOM   5371 C CG  . ASN B 2 272 ? 153.986 148.466 109.753 1.00 59.13  ?  254 ASN B CG  1 
ATOM   5372 O OD1 . ASN B 2 272 ? 153.059 148.308 108.961 1.00 59.13  ?  254 ASN B OD1 1 
ATOM   5373 N ND2 . ASN B 2 272 ? 154.832 149.483 109.670 1.00 59.13  ?  254 ASN B ND2 1 
ATOM   5374 N N   . PRO B 2 273 ? 152.831 144.309 112.103 1.00 57.97  ?  255 PRO B N   1 
ATOM   5375 C CA  . PRO B 2 273 ? 153.023 143.360 113.210 1.00 57.97  ?  255 PRO B CA  1 
ATOM   5376 C C   . PRO B 2 273 ? 154.448 142.864 113.348 1.00 57.97  ?  255 PRO B C   1 
ATOM   5377 O O   . PRO B 2 273 ? 154.820 142.404 114.432 1.00 57.97  ?  255 PRO B O   1 
ATOM   5378 C CB  . PRO B 2 273 ? 152.068 142.211 112.862 1.00 57.97  ?  255 PRO B CB  1 
ATOM   5379 C CG  . PRO B 2 273 ? 151.181 142.744 111.783 1.00 57.97  ?  255 PRO B CG  1 
ATOM   5380 C CD  . PRO B 2 273 ? 151.991 143.743 111.041 1.00 57.97  ?  255 PRO B CD  1 
ATOM   5381 N N   . GLU B 2 274 ? 155.256 142.949 112.295 1.00 60.49  ?  256 GLU B N   1 
ATOM   5382 C CA  . GLU B 2 274 ? 156.670 142.623 112.395 1.00 60.49  ?  256 GLU B CA  1 
ATOM   5383 C C   . GLU B 2 274 ? 157.480 143.731 113.048 1.00 60.49  ?  256 GLU B C   1 
ATOM   5384 O O   . GLU B 2 274 ? 158.635 143.497 113.415 1.00 60.49  ?  256 GLU B O   1 
ATOM   5385 C CB  . GLU B 2 274 ? 157.233 142.318 111.010 1.00 60.49  ?  256 GLU B CB  1 
ATOM   5386 C CG  . GLU B 2 274 ? 156.537 141.164 110.321 1.00 60.49  ?  256 GLU B CG  1 
ATOM   5387 C CD  . GLU B 2 274 ? 157.016 140.958 108.903 1.00 60.49  ?  256 GLU B CD  1 
ATOM   5388 O OE1 . GLU B 2 274 ? 156.417 140.130 108.189 1.00 60.49  ?  256 GLU B OE1 1 
ATOM   5389 O OE2 . GLU B 2 274 ? 157.991 141.625 108.501 1.00 60.49  -1 256 GLU B OE2 1 
ATOM   5390 N N   . ARG B 2 275 ? 156.908 144.922 113.204 1.00 56.71  ?  257 ARG B N   1 
ATOM   5391 C CA  . ARG B 2 275 ? 157.551 146.020 113.908 1.00 56.71  ?  257 ARG B CA  1 
ATOM   5392 C C   . ARG B 2 275 ? 156.818 146.417 115.179 1.00 56.71  ?  257 ARG B C   1 
ATOM   5393 O O   . ARG B 2 275 ? 157.441 146.540 116.233 1.00 56.71  ?  257 ARG B O   1 
ATOM   5394 C CB  . ARG B 2 275 ? 157.672 147.242 112.990 1.00 56.71  ?  257 ARG B CB  1 
ATOM   5395 C CG  . ARG B 2 275 ? 158.329 148.434 113.657 1.00 56.71  ?  257 ARG B CG  1 
ATOM   5396 C CD  . ARG B 2 275 ? 158.345 149.646 112.754 1.00 56.71  ?  257 ARG B CD  1 
ATOM   5397 N NE  . ARG B 2 275 ? 159.134 150.734 113.321 1.00 56.71  ?  257 ARG B NE  1 
ATOM   5398 C CZ  . ARG B 2 275 ? 158.620 151.774 113.969 1.00 56.71  ?  257 ARG B CZ  1 
ATOM   5399 N NH1 . ARG B 2 275 ? 157.310 151.873 114.134 1.00 56.71  1  257 ARG B NH1 1 
ATOM   5400 N NH2 . ARG B 2 275 ? 159.417 152.719 114.449 1.00 56.71  ?  257 ARG B NH2 1 
ATOM   5401 N N   . ASN B 2 276 ? 155.501 146.607 115.112 1.00 53.80  ?  258 ASN B N   1 
ATOM   5402 C CA  . ASN B 2 276 ? 154.781 147.231 116.214 1.00 53.80  ?  258 ASN B CA  1 
ATOM   5403 C C   . ASN B 2 276 ? 154.491 146.289 117.374 1.00 53.80  ?  258 ASN B C   1 
ATOM   5404 O O   . ASN B 2 276 ? 154.172 146.767 118.462 1.00 53.80  ?  258 ASN B O   1 
ATOM   5405 C CB  . ASN B 2 276 ? 153.470 147.836 115.713 1.00 53.80  ?  258 ASN B CB  1 
ATOM   5406 C CG  . ASN B 2 276 ? 153.685 149.097 114.911 1.00 53.80  ?  258 ASN B CG  1 
ATOM   5407 O OD1 . ASN B 2 276 ? 152.907 149.416 114.017 1.00 53.80  ?  258 ASN B OD1 1 
ATOM   5408 N ND2 . ASN B 2 276 ? 154.749 149.821 115.223 1.00 53.80  ?  258 ASN B ND2 1 
ATOM   5409 N N   . LEU B 2 277 ? 154.582 144.982 117.185 1.00 51.19  ?  259 LEU B N   1 
ATOM   5410 C CA  . LEU B 2 277 ? 154.402 144.083 118.323 1.00 51.19  ?  259 LEU B CA  1 
ATOM   5411 C C   . LEU B 2 277 ? 155.638 144.000 119.235 1.00 51.19  ?  259 LEU B C   1 
ATOM   5412 O O   . LEU B 2 277 ? 155.487 144.238 120.448 1.00 51.19  ?  259 LEU B O   1 
ATOM   5413 C CB  . LEU B 2 277 ? 153.957 142.695 117.842 1.00 51.19  ?  259 LEU B CB  1 
ATOM   5414 C CG  . LEU B 2 277 ? 153.797 141.614 118.908 1.00 51.19  ?  259 LEU B CG  1 
ATOM   5415 C CD1 . LEU B 2 277 ? 152.444 141.719 119.576 1.00 51.19  ?  259 LEU B CD1 1 
ATOM   5416 C CD2 . LEU B 2 277 ? 153.986 140.245 118.298 1.00 51.19  ?  259 LEU B CD2 1 
ATOM   5417 N N   . PRO B 2 278 ? 156.864 143.697 118.750 1.00 51.47  ?  260 PRO B N   1 
ATOM   5418 C CA  . PRO B 2 278 ? 157.986 143.642 119.699 1.00 51.47  ?  260 PRO B CA  1 
ATOM   5419 C C   . PRO B 2 278 ? 158.401 145.004 120.214 1.00 51.47  ?  260 PRO B C   1 
ATOM   5420 O O   . PRO B 2 278 ? 158.883 145.097 121.349 1.00 51.47  ?  260 PRO B O   1 
ATOM   5421 C CB  . PRO B 2 278 ? 159.114 142.987 118.886 1.00 51.47  ?  260 PRO B CB  1 
ATOM   5422 C CG  . PRO B 2 278 ? 158.479 142.476 117.664 1.00 51.47  ?  260 PRO B CG  1 
ATOM   5423 C CD  . PRO B 2 278 ? 157.385 143.417 117.396 1.00 51.47  ?  260 PRO B CD  1 
ATOM   5424 N N   . LEU B 2 279 ? 158.200 146.063 119.427 1.00 50.22  ?  261 LEU B N   1 
ATOM   5425 C CA  . LEU B 2 279 ? 158.510 147.409 119.893 1.00 50.22  ?  261 LEU B CA  1 
ATOM   5426 C C   . LEU B 2 279 ? 157.584 147.827 121.026 1.00 50.22  ?  261 LEU B C   1 
ATOM   5427 O O   . LEU B 2 279 ? 158.035 148.418 122.010 1.00 50.22  ?  261 LEU B O   1 
ATOM   5428 C CB  . LEU B 2 279 ? 158.421 148.398 118.735 1.00 50.22  ?  261 LEU B CB  1 
ATOM   5429 C CG  . LEU B 2 279 ? 158.766 149.856 119.018 1.00 50.22  ?  261 LEU B CG  1 
ATOM   5430 C CD1 . LEU B 2 279 ? 160.138 149.965 119.643 1.00 50.22  ?  261 LEU B CD1 1 
ATOM   5431 C CD2 . LEU B 2 279 ? 158.702 150.655 117.737 1.00 50.22  ?  261 LEU B CD2 1 
ATOM   5432 N N   . SER B 2 280 ? 156.298 147.485 120.934 1.00 48.70  ?  262 SER B N   1 
ATOM   5433 C CA  . SER B 2 280 ? 155.382 147.834 122.013 1.00 48.70  ?  262 SER B CA  1 
ATOM   5434 C C   . SER B 2 280 ? 155.604 146.972 123.248 1.00 48.70  ?  262 SER B C   1 
ATOM   5435 O O   . SER B 2 280 ? 155.441 147.466 124.369 1.00 48.70  ?  262 SER B O   1 
ATOM   5436 C CB  . SER B 2 280 ? 153.938 147.717 121.551 1.00 48.70  ?  262 SER B CB  1 
ATOM   5437 O OG  . SER B 2 280 ? 153.484 146.402 121.749 1.00 48.70  ?  262 SER B OG  1 
ATOM   5438 N N   . ILE B 2 281 ? 155.997 145.705 123.071 1.00 49.48  ?  263 ILE B N   1 
ATOM   5439 C CA  . ILE B 2 281 ? 156.341 144.870 124.226 1.00 49.48  ?  263 ILE B CA  1 
ATOM   5440 C C   . ILE B 2 281 ? 157.579 145.418 124.938 1.00 49.48  ?  263 ILE B C   1 
ATOM   5441 O O   . ILE B 2 281 ? 157.602 145.563 126.172 1.00 49.48  ?  263 ILE B O   1 
ATOM   5442 C CB  . ILE B 2 281 ? 156.528 143.406 123.785 1.00 49.48  ?  263 ILE B CB  1 
ATOM   5443 C CG1 . ILE B 2 281 ? 155.170 142.761 123.511 1.00 49.48  ?  263 ILE B CG1 1 
ATOM   5444 C CG2 . ILE B 2 281 ? 157.284 142.603 124.828 1.00 49.48  ?  263 ILE B CG2 1 
ATOM   5445 C CD1 . ILE B 2 281 ? 155.255 141.351 122.981 1.00 49.48  ?  263 ILE B CD1 1 
ATOM   5446 N N   . GLY B 2 282 ? 158.611 145.768 124.166 1.00 50.08  ?  264 GLY B N   1 
ATOM   5447 C CA  . GLY B 2 282 ? 159.825 146.321 124.736 1.00 50.08  ?  264 GLY B CA  1 
ATOM   5448 C C   . GLY B 2 282 ? 159.677 147.722 125.283 1.00 50.08  ?  264 GLY B C   1 
ATOM   5449 O O   . GLY B 2 282 ? 160.506 148.146 126.093 1.00 50.08  ?  264 GLY B O   1 
ATOM   5450 N N   . ILE B 2 283 ? 158.657 148.459 124.850 1.00 49.66  ?  265 ILE B N   1 
ATOM   5451 C CA  . ILE B 2 283 ? 158.357 149.736 125.486 1.00 49.66  ?  265 ILE B CA  1 
ATOM   5452 C C   . ILE B 2 283 ? 157.600 149.516 126.792 1.00 49.66  ?  265 ILE B C   1 
ATOM   5453 O O   . ILE B 2 283 ? 157.925 150.119 127.820 1.00 49.66  ?  265 ILE B O   1 
ATOM   5454 C CB  . ILE B 2 283 ? 157.585 150.647 124.509 1.00 49.66  ?  265 ILE B CB  1 
ATOM   5455 C CG1 . ILE B 2 283 ? 158.534 151.274 123.487 1.00 49.66  ?  265 ILE B CG1 1 
ATOM   5456 C CG2 . ILE B 2 283 ? 156.835 151.751 125.236 1.00 49.66  ?  265 ILE B CG2 1 
ATOM   5457 C CD1 . ILE B 2 283 ? 159.526 152.240 124.078 1.00 49.66  ?  265 ILE B CD1 1 
ATOM   5458 N N   . SER B 2 284 ? 156.616 148.615 126.795 1.00 48.94  ?  266 SER B N   1 
ATOM   5459 C CA  . SER B 2 284 ? 155.732 148.498 127.946 1.00 48.94  ?  266 SER B CA  1 
ATOM   5460 C C   . SER B 2 284 ? 156.318 147.692 129.101 1.00 48.94  ?  266 SER B C   1 
ATOM   5461 O O   . SER B 2 284 ? 155.806 147.806 130.217 1.00 48.94  ?  266 SER B O   1 
ATOM   5462 C CB  . SER B 2 284 ? 154.401 147.878 127.522 1.00 48.94  ?  266 SER B CB  1 
ATOM   5463 O OG  . SER B 2 284 ? 154.571 146.530 127.142 1.00 48.94  ?  266 SER B OG  1 
ATOM   5464 N N   . MET B 2 285 ? 157.359 146.874 128.877 1.00 52.37  ?  267 MET B N   1 
ATOM   5465 C CA  . MET B 2 285 ? 157.926 146.120 130.000 1.00 52.37  ?  267 MET B CA  1 
ATOM   5466 C C   . MET B 2 285 ? 158.651 146.984 131.041 1.00 52.37  ?  267 MET B C   1 
ATOM   5467 O O   . MET B 2 285 ? 158.310 146.871 132.238 1.00 52.37  ?  267 MET B O   1 
ATOM   5468 C CB  . MET B 2 285 ? 158.818 144.983 129.479 1.00 52.37  ?  267 MET B CB  1 
ATOM   5469 C CG  . MET B 2 285 ? 158.086 143.745 129.017 1.00 52.37  ?  267 MET B CG  1 
ATOM   5470 S SD  . MET B 2 285 ? 156.615 143.375 129.976 1.00 52.37  ?  267 MET B SD  1 
ATOM   5471 C CE  . MET B 2 285 ? 155.375 143.680 128.730 1.00 52.37  ?  267 MET B CE  1 
ATOM   5472 N N   . PRO B 2 286 ? 159.640 147.841 130.699 1.00 50.62  ?  268 PRO B N   1 
ATOM   5473 C CA  . PRO B 2 286 ? 160.336 148.569 131.774 1.00 50.62  ?  268 PRO B CA  1 
ATOM   5474 C C   . PRO B 2 286 ? 159.498 149.644 132.433 1.00 50.62  ?  268 PRO B C   1 
ATOM   5475 O O   . PRO B 2 286 ? 159.795 150.004 133.577 1.00 50.62  ?  268 PRO B O   1 
ATOM   5476 C CB  . PRO B 2 286 ? 161.550 149.174 131.062 1.00 50.62  ?  268 PRO B CB  1 
ATOM   5477 C CG  . PRO B 2 286 ? 161.085 149.399 129.716 1.00 50.62  ?  268 PRO B CG  1 
ATOM   5478 C CD  . PRO B 2 286 ? 160.237 148.216 129.395 1.00 50.62  ?  268 PRO B CD  1 
ATOM   5479 N N   . ILE B 2 287 ? 158.451 150.134 131.767 1.00 49.29  ?  269 ILE B N   1 
ATOM   5480 C CA  . ILE B 2 287 ? 157.528 151.085 132.384 1.00 49.29  ?  269 ILE B CA  1 
ATOM   5481 C C   . ILE B 2 287 ? 156.815 150.440 133.567 1.00 49.29  ?  269 ILE B C   1 
ATOM   5482 O O   . ILE B 2 287 ? 156.781 150.995 134.674 1.00 49.29  ?  269 ILE B O   1 
ATOM   5483 C CB  . ILE B 2 287 ? 156.529 151.607 131.336 1.00 49.29  ?  269 ILE B CB  1 
ATOM   5484 C CG1 . ILE B 2 287 ? 157.236 152.530 130.345 1.00 49.29  ?  269 ILE B CG1 1 
ATOM   5485 C CG2 . ILE B 2 287 ? 155.361 152.317 131.995 1.00 49.29  ?  269 ILE B CG2 1 
ATOM   5486 C CD1 . ILE B 2 287 ? 156.331 153.078 129.270 1.00 49.29  ?  269 ILE B CD1 1 
ATOM   5487 N N   . VAL B 2 288 ? 156.280 149.235 133.358 1.00 48.14  ?  270 VAL B N   1 
ATOM   5488 C CA  . VAL B 2 288 ? 155.568 148.524 134.414 1.00 48.14  ?  270 VAL B CA  1 
ATOM   5489 C C   . VAL B 2 288 ? 156.531 148.085 135.513 1.00 48.14  ?  270 VAL B C   1 
ATOM   5490 O O   . VAL B 2 288 ? 156.197 148.153 136.703 1.00 48.14  ?  270 VAL B O   1 
ATOM   5491 C CB  . VAL B 2 288 ? 154.787 147.340 133.811 1.00 48.14  ?  270 VAL B CB  1 
ATOM   5492 C CG1 . VAL B 2 288 ? 154.077 146.539 134.881 1.00 48.14  ?  270 VAL B CG1 1 
ATOM   5493 C CG2 . VAL B 2 288 ? 153.773 147.846 132.811 1.00 48.14  ?  270 VAL B CG2 1 
ATOM   5494 N N   . THR B 2 289 ? 157.762 147.701 135.145 1.00 49.44  ?  271 THR B N   1 
ATOM   5495 C CA  . THR B 2 289 ? 158.735 147.303 136.167 1.00 49.44  ?  271 THR B CA  1 
ATOM   5496 C C   . THR B 2 289 ? 159.159 148.479 137.051 1.00 49.44  ?  271 THR B C   1 
ATOM   5497 O O   . THR B 2 289 ? 159.190 148.356 138.286 1.00 49.44  ?  271 THR B O   1 
ATOM   5498 C CB  . THR B 2 289 ? 159.956 146.665 135.508 1.00 49.44  ?  271 THR B CB  1 
ATOM   5499 O OG1 . THR B 2 289 ? 159.531 145.605 134.648 1.00 49.44  ?  271 THR B OG1 1 
ATOM   5500 C CG2 . THR B 2 289 ? 160.889 146.097 136.558 1.00 49.44  ?  271 THR B CG2 1 
ATOM   5501 N N   . ILE B 2 290 ? 159.453 149.632 136.439 1.00 47.59  ?  272 ILE B N   1 
ATOM   5502 C CA  . ILE B 2 290 ? 159.851 150.821 137.189 1.00 47.59  ?  272 ILE B CA  1 
ATOM   5503 C C   . ILE B 2 290 ? 158.703 151.323 138.059 1.00 47.59  ?  272 ILE B C   1 
ATOM   5504 O O   . ILE B 2 290 ? 158.911 151.701 139.221 1.00 47.59  ?  272 ILE B O   1 
ATOM   5505 C CB  . ILE B 2 290 ? 160.359 151.897 136.208 1.00 47.59  ?  272 ILE B CB  1 
ATOM   5506 C CG1 . ILE B 2 290 ? 161.767 151.549 135.732 1.00 47.59  ?  272 ILE B CG1 1 
ATOM   5507 C CG2 . ILE B 2 290 ? 160.365 153.284 136.827 1.00 47.59  ?  272 ILE B CG2 1 
ATOM   5508 C CD1 . ILE B 2 290 ? 162.245 152.407 134.588 1.00 47.59  ?  272 ILE B CD1 1 
ATOM   5509 N N   . ILE B 2 291 ? 157.473 151.290 137.530 1.00 47.48  ?  273 ILE B N   1 
ATOM   5510 C CA  . ILE B 2 291 ? 156.308 151.733 138.290 1.00 47.48  ?  273 ILE B CA  1 
ATOM   5511 C C   . ILE B 2 291 ? 156.065 150.820 139.488 1.00 47.48  ?  273 ILE B C   1 
ATOM   5512 O O   . ILE B 2 291 ? 155.799 151.296 140.601 1.00 47.48  ?  273 ILE B O   1 
ATOM   5513 C CB  . ILE B 2 291 ? 155.085 151.816 137.354 1.00 47.48  ?  273 ILE B CB  1 
ATOM   5514 C CG1 . ILE B 2 291 ? 155.075 153.152 136.614 1.00 47.48  ?  273 ILE B CG1 1 
ATOM   5515 C CG2 . ILE B 2 291 ? 153.771 151.634 138.097 1.00 47.48  ?  273 ILE B CG2 1 
ATOM   5516 C CD1 . ILE B 2 291 ? 153.976 153.267 135.588 1.00 47.48  ?  273 ILE B CD1 1 
ATOM   5517 N N   . TYR B 2 292 ? 156.223 149.505 139.300 1.00 49.97  ?  274 TYR B N   1 
ATOM   5518 C CA  . TYR B 2 292 ? 156.003 148.561 140.390 1.00 49.97  ?  274 TYR B CA  1 
ATOM   5519 C C   . TYR B 2 292 ? 157.069 148.673 141.471 1.00 49.97  ?  274 TYR B C   1 
ATOM   5520 O O   . TYR B 2 292 ? 156.771 148.457 142.649 1.00 49.97  ?  274 TYR B O   1 
ATOM   5521 C CB  . TYR B 2 292 ? 155.963 147.134 139.851 1.00 49.97  ?  274 TYR B CB  1 
ATOM   5522 C CG  . TYR B 2 292 ? 154.607 146.679 139.365 1.00 49.97  ?  274 TYR B CG  1 
ATOM   5523 C CD1 . TYR B 2 292 ? 153.584 147.587 139.134 1.00 49.97  ?  274 TYR B CD1 1 
ATOM   5524 C CD2 . TYR B 2 292 ? 154.353 145.337 139.136 1.00 49.97  ?  274 TYR B CD2 1 
ATOM   5525 C CE1 . TYR B 2 292 ? 152.351 147.172 138.688 1.00 49.97  ?  274 TYR B CE1 1 
ATOM   5526 C CE2 . TYR B 2 292 ? 153.123 144.912 138.692 1.00 49.97  ?  274 TYR B CE2 1 
ATOM   5527 C CZ  . TYR B 2 292 ? 152.126 145.833 138.471 1.00 49.97  ?  274 TYR B CZ  1 
ATOM   5528 O OH  . TYR B 2 292 ? 150.896 145.413 138.030 1.00 49.97  ?  274 TYR B OH  1 
ATOM   5529 N N   . ILE B 2 293 ? 158.307 149.002 141.104 1.00 49.32  ?  275 ILE B N   1 
ATOM   5530 C CA  . ILE B 2 293 ? 159.341 149.179 142.122 1.00 49.32  ?  275 ILE B CA  1 
ATOM   5531 C C   . ILE B 2 293 ? 159.124 150.483 142.889 1.00 49.32  ?  275 ILE B C   1 
ATOM   5532 O O   . ILE B 2 293 ? 159.174 150.513 144.129 1.00 49.32  ?  275 ILE B O   1 
ATOM   5533 C CB  . ILE B 2 293 ? 160.738 149.114 141.477 1.00 49.32  ?  275 ILE B CB  1 
ATOM   5534 C CG1 . ILE B 2 293 ? 161.041 147.687 141.029 1.00 49.32  ?  275 ILE B CG1 1 
ATOM   5535 C CG2 . ILE B 2 293 ? 161.814 149.583 142.436 1.00 49.32  ?  275 ILE B CG2 1 
ATOM   5536 C CD1 . ILE B 2 293 ? 162.305 147.567 140.224 1.00 49.32  ?  275 ILE B CD1 1 
ATOM   5537 N N   . LEU B 2 294 ? 158.845 151.575 142.168 1.00 48.95  ?  276 LEU B N   1 
ATOM   5538 C CA  . LEU B 2 294 ? 158.756 152.881 142.812 1.00 48.95  ?  276 LEU B CA  1 
ATOM   5539 C C   . LEU B 2 294 ? 157.493 153.028 143.651 1.00 48.95  ?  276 LEU B C   1 
ATOM   5540 O O   . LEU B 2 294 ? 157.507 153.747 144.658 1.00 48.95  ?  276 LEU B O   1 
ATOM   5541 C CB  . LEU B 2 294 ? 158.832 153.989 141.764 1.00 48.95  ?  276 LEU B CB  1 
ATOM   5542 C CG  . LEU B 2 294 ? 160.217 154.232 141.166 1.00 48.95  ?  276 LEU B CG  1 
ATOM   5543 C CD1 . LEU B 2 294 ? 160.190 155.413 140.223 1.00 48.95  ?  276 LEU B CD1 1 
ATOM   5544 C CD2 . LEU B 2 294 ? 161.241 154.451 142.257 1.00 48.95  ?  276 LEU B CD2 1 
ATOM   5545 N N   . THR B 2 295 ? 156.409 152.334 143.287 1.00 49.97  ?  277 THR B N   1 
ATOM   5546 C CA  . THR B 2 295 ? 155.206 152.379 144.110 1.00 49.97  ?  277 THR B CA  1 
ATOM   5547 C C   . THR B 2 295 ? 155.423 151.677 145.443 1.00 49.97  ?  277 THR B C   1 
ATOM   5548 O O   . THR B 2 295 ? 154.931 152.135 146.478 1.00 49.97  ?  277 THR B O   1 
ATOM   5549 C CB  . THR B 2 295 ? 154.033 151.755 143.361 1.00 49.97  ?  277 THR B CB  1 
ATOM   5550 O OG1 . THR B 2 295 ? 154.067 152.185 141.997 1.00 49.97  ?  277 THR B OG1 1 
ATOM   5551 C CG2 . THR B 2 295 ? 152.720 152.181 143.979 1.00 49.97  ?  277 THR B CG2 1 
ATOM   5552 N N   . ASN B 2 296 ? 156.197 150.594 145.449 1.00 52.18  ?  278 ASN B N   1 
ATOM   5553 C CA  . ASN B 2 296 ? 156.484 149.919 146.708 1.00 52.18  ?  278 ASN B CA  1 
ATOM   5554 C C   . ASN B 2 296 ? 157.476 150.703 147.552 1.00 52.18  ?  278 ASN B C   1 
ATOM   5555 O O   . ASN B 2 296 ? 157.378 150.683 148.784 1.00 52.18  ?  278 ASN B O   1 
ATOM   5556 C CB  . ASN B 2 296 ? 156.992 148.508 146.441 1.00 52.18  ?  278 ASN B CB  1 
ATOM   5557 C CG  . ASN B 2 296 ? 155.874 147.544 146.154 1.00 52.18  ?  278 ASN B CG  1 
ATOM   5558 O OD1 . ASN B 2 296 ? 155.441 147.402 145.016 1.00 52.18  ?  278 ASN B OD1 1 
ATOM   5559 N ND2 . ASN B 2 296 ? 155.390 146.878 147.189 1.00 52.18  ?  278 ASN B ND2 1 
ATOM   5560 N N   . VAL B 2 297 ? 158.414 151.412 146.916 1.00 52.44  ?  279 VAL B N   1 
ATOM   5561 C CA  . VAL B 2 297 ? 159.295 152.312 147.665 1.00 52.44  ?  279 VAL B CA  1 
ATOM   5562 C C   . VAL B 2 297 ? 158.486 153.427 148.325 1.00 52.44  ?  279 VAL B C   1 
ATOM   5563 O O   . VAL B 2 297 ? 158.696 153.760 149.502 1.00 52.44  ?  279 VAL B O   1 
ATOM   5564 C CB  . VAL B 2 297 ? 160.397 152.867 146.742 1.00 52.44  ?  279 VAL B CB  1 
ATOM   5565 C CG1 . VAL B 2 297 ? 161.158 154.000 147.405 1.00 52.44  ?  279 VAL B CG1 1 
ATOM   5566 C CG2 . VAL B 2 297 ? 161.354 151.765 146.353 1.00 52.44  ?  279 VAL B CG2 1 
ATOM   5567 N N   . ALA B 2 298 ? 157.509 153.979 147.598 1.00 53.67  ?  280 ALA B N   1 
ATOM   5568 C CA  . ALA B 2 298 ? 156.631 154.998 148.166 1.00 53.67  ?  280 ALA B CA  1 
ATOM   5569 C C   . ALA B 2 298 ? 155.727 154.439 149.260 1.00 53.67  ?  280 ALA B C   1 
ATOM   5570 O O   . ALA B 2 298 ? 155.385 155.161 150.200 1.00 53.67  ?  280 ALA B O   1 
ATOM   5571 C CB  . ALA B 2 298 ? 155.787 155.633 147.064 1.00 53.67  ?  280 ALA B CB  1 
ATOM   5572 N N   . TYR B 2 299 ? 155.323 153.171 149.150 1.00 53.02  ?  281 TYR B N   1 
ATOM   5573 C CA  . TYR B 2 299 ? 154.544 152.542 150.213 1.00 53.02  ?  281 TYR B CA  1 
ATOM   5574 C C   . TYR B 2 299 ? 155.374 152.356 151.474 1.00 53.02  ?  281 TYR B C   1 
ATOM   5575 O O   . TYR B 2 299 ? 154.875 152.550 152.586 1.00 53.02  ?  281 TYR B O   1 
ATOM   5576 C CB  . TYR B 2 299 ? 154.009 151.187 149.758 1.00 53.02  ?  281 TYR B CB  1 
ATOM   5577 C CG  . TYR B 2 299 ? 152.837 151.234 148.814 1.00 53.02  ?  281 TYR B CG  1 
ATOM   5578 C CD1 . TYR B 2 299 ? 152.052 152.371 148.699 1.00 53.02  ?  281 TYR B CD1 1 
ATOM   5579 C CD2 . TYR B 2 299 ? 152.512 150.129 148.039 1.00 53.02  ?  281 TYR B CD2 1 
ATOM   5580 C CE1 . TYR B 2 299 ? 150.980 152.406 147.833 1.00 53.02  ?  281 TYR B CE1 1 
ATOM   5581 C CE2 . TYR B 2 299 ? 151.446 150.154 147.175 1.00 53.02  ?  281 TYR B CE2 1 
ATOM   5582 C CZ  . TYR B 2 299 ? 150.684 151.292 147.074 1.00 53.02  ?  281 TYR B CZ  1 
ATOM   5583 O OH  . TYR B 2 299 ? 149.620 151.309 146.208 1.00 53.02  ?  281 TYR B OH  1 
ATOM   5584 N N   . TYR B 2 300 ? 156.640 151.968 151.324 1.00 56.63  ?  282 TYR B N   1 
ATOM   5585 C CA  . TYR B 2 300 ? 157.462 151.678 152.492 1.00 56.63  ?  282 TYR B CA  1 
ATOM   5586 C C   . TYR B 2 300 ? 158.024 152.937 153.133 1.00 56.63  ?  282 TYR B C   1 
ATOM   5587 O O   . TYR B 2 300 ? 158.440 152.888 154.293 1.00 56.63  ?  282 TYR B O   1 
ATOM   5588 C CB  . TYR B 2 300 ? 158.620 150.741 152.136 1.00 56.63  ?  282 TYR B CB  1 
ATOM   5589 C CG  . TYR B 2 300 ? 158.233 149.423 151.495 1.00 56.63  ?  282 TYR B CG  1 
ATOM   5590 C CD1 . TYR B 2 300 ? 156.995 148.835 151.734 1.00 56.63  ?  282 TYR B CD1 1 
ATOM   5591 C CD2 . TYR B 2 300 ? 159.120 148.762 150.657 1.00 56.63  ?  282 TYR B CD2 1 
ATOM   5592 C CE1 . TYR B 2 300 ? 156.649 147.640 151.140 1.00 56.63  ?  282 TYR B CE1 1 
ATOM   5593 C CE2 . TYR B 2 300 ? 158.782 147.566 150.063 1.00 56.63  ?  282 TYR B CE2 1 
ATOM   5594 C CZ  . TYR B 2 300 ? 157.548 147.010 150.311 1.00 56.63  ?  282 TYR B CZ  1 
ATOM   5595 O OH  . TYR B 2 300 ? 157.208 145.817 149.724 1.00 56.63  ?  282 TYR B OH  1 
ATOM   5596 N N   . THR B 2 301 ? 158.066 154.051 152.400 1.00 59.27  ?  283 THR B N   1 
ATOM   5597 C CA  . THR B 2 301 ? 158.530 155.301 152.996 1.00 59.27  ?  283 THR B CA  1 
ATOM   5598 C C   . THR B 2 301 ? 157.525 155.847 154.004 1.00 59.27  ?  283 THR B C   1 
ATOM   5599 O O   . THR B 2 301 ? 157.903 156.262 155.106 1.00 59.27  ?  283 THR B O   1 
ATOM   5600 C CB  . THR B 2 301 ? 158.800 156.328 151.898 1.00 59.27  ?  283 THR B CB  1 
ATOM   5601 O OG1 . THR B 2 301 ? 159.847 155.851 151.047 1.00 59.27  ?  283 THR B OG1 1 
ATOM   5602 C CG2 . THR B 2 301 ? 159.213 157.658 152.484 1.00 59.27  ?  283 THR B CG2 1 
ATOM   5603 N N   . VAL B 2 302 ? 156.243 155.821 153.664 1.00 59.35  ?  284 VAL B N   1 
ATOM   5604 C CA  . VAL B 2 302 ? 155.219 156.464 154.479 1.00 59.35  ?  284 VAL B CA  1 
ATOM   5605 C C   . VAL B 2 302 ? 154.711 155.535 155.574 1.00 59.35  ?  284 VAL B C   1 
ATOM   5606 O O   . VAL B 2 302 ? 154.593 155.930 156.737 1.00 59.35  ?  284 VAL B O   1 
ATOM   5607 C CB  . VAL B 2 302 ? 154.080 156.956 153.562 1.00 59.35  ?  284 VAL B CB  1 
ATOM   5608 C CG1 . VAL B 2 302 ? 152.858 157.363 154.361 1.00 59.35  ?  284 VAL B CG1 1 
ATOM   5609 C CG2 . VAL B 2 302 ? 154.571 158.111 152.725 1.00 59.35  ?  284 VAL B CG2 1 
ATOM   5610 N N   . LEU B 2 303 ? 154.424 154.288 155.231 1.00 61.16  ?  285 LEU B N   1 
ATOM   5611 C CA  . LEU B 2 303 ? 153.872 153.321 156.163 1.00 61.16  ?  285 LEU B CA  1 
ATOM   5612 C C   . LEU B 2 303 ? 154.981 152.426 156.707 1.00 61.16  ?  285 LEU B C   1 
ATOM   5613 O O   . LEU B 2 303 ? 155.973 152.162 156.026 1.00 61.16  ?  285 LEU B O   1 
ATOM   5614 C CB  . LEU B 2 303 ? 152.817 152.464 155.467 1.00 61.16  ?  285 LEU B CB  1 
ATOM   5615 C CG  . LEU B 2 303 ? 151.643 153.180 154.802 1.00 61.16  ?  285 LEU B CG  1 
ATOM   5616 C CD1 . LEU B 2 303 ? 150.809 152.193 154.017 1.00 61.16  ?  285 LEU B CD1 1 
ATOM   5617 C CD2 . LEU B 2 303 ? 150.793 153.884 155.816 1.00 61.16  ?  285 LEU B CD2 1 
ATOM   5618 N N   . ASP B 2 304 ? 154.812 151.964 157.944 1.00 68.40  ?  286 ASP B N   1 
ATOM   5619 C CA  . ASP B 2 304 ? 155.694 150.933 158.466 1.00 68.40  ?  286 ASP B CA  1 
ATOM   5620 C C   . ASP B 2 304 ? 155.099 149.560 158.156 1.00 68.40  ?  286 ASP B C   1 
ATOM   5621 O O   . ASP B 2 304 ? 154.120 149.441 157.423 1.00 68.40  ?  286 ASP B O   1 
ATOM   5622 C CB  . ASP B 2 304 ? 155.957 151.134 159.959 1.00 68.40  ?  286 ASP B CB  1 
ATOM   5623 C CG  . ASP B 2 304 ? 154.693 151.339 160.757 1.00 68.40  ?  286 ASP B CG  1 
ATOM   5624 O OD1 . ASP B 2 304 ? 153.623 151.499 160.148 1.00 68.40  ?  286 ASP B OD1 1 
ATOM   5625 O OD2 . ASP B 2 304 ? 154.771 151.343 162.002 1.00 68.40  -1 286 ASP B OD2 1 
ATOM   5626 N N   . MET B 2 305 ? 155.699 148.503 158.703 1.00 68.10  ?  287 MET B N   1 
ATOM   5627 C CA  . MET B 2 305 ? 155.337 147.161 158.256 1.00 68.10  ?  287 MET B CA  1 
ATOM   5628 C C   . MET B 2 305 ? 154.012 146.677 158.837 1.00 68.10  ?  287 MET B C   1 
ATOM   5629 O O   . MET B 2 305 ? 153.272 145.954 158.156 1.00 68.10  ?  287 MET B O   1 
ATOM   5630 C CB  . MET B 2 305 ? 156.453 146.174 158.602 1.00 68.10  ?  287 MET B CB  1 
ATOM   5631 C CG  . MET B 2 305 ? 156.429 144.910 157.758 1.00 68.10  ?  287 MET B CG  1 
ATOM   5632 S SD  . MET B 2 305 ? 157.848 143.839 158.027 1.00 68.10  ?  287 MET B SD  1 
ATOM   5633 C CE  . MET B 2 305 ? 159.145 144.807 157.271 1.00 68.10  ?  287 MET B CE  1 
ATOM   5634 N N   . ARG B 2 306 ? 153.763 147.028 160.091 1.00 71.57  ?  288 ARG B N   1 
ATOM   5635 C CA  . ARG B 2 306 ? 152.577 146.593 160.813 1.00 71.57  ?  288 ARG B CA  1 
ATOM   5636 C C   . ARG B 2 306 ? 151.240 147.001 160.204 1.00 71.57  ?  288 ARG B C   1 
ATOM   5637 O O   . ARG B 2 306 ? 150.321 146.190 160.133 1.00 71.57  ?  288 ARG B O   1 
ATOM   5638 C CB  . ARG B 2 306 ? 152.677 147.002 162.296 1.00 71.57  ?  288 ARG B CB  1 
ATOM   5639 C CG  . ARG B 2 306 ? 151.826 148.191 162.725 1.00 71.57  ?  288 ARG B CG  1 
ATOM   5640 C CD  . ARG B 2 306 ? 150.907 147.813 163.875 1.00 71.57  ?  288 ARG B CD  1 
ATOM   5641 N NE  . ARG B 2 306 ? 151.072 148.671 165.047 1.00 71.57  ?  288 ARG B NE  1 
ATOM   5642 C CZ  . ARG B 2 306 ? 152.242 149.104 165.509 1.00 71.57  ?  288 ARG B CZ  1 
ATOM   5643 N NH1 . ARG B 2 306 ? 153.369 148.769 164.899 1.00 71.57  1  288 ARG B NH1 1 
ATOM   5644 N NH2 . ARG B 2 306 ? 152.286 149.878 166.584 1.00 71.57  ?  288 ARG B NH2 1 
ATOM   5645 N N   . ASP B 2 307 ? 151.120 148.251 159.774 1.00 70.04  ?  289 ASP B N   1 
ATOM   5646 C CA  . ASP B 2 307 ? 149.852 148.696 159.207 1.00 70.04  ?  289 ASP B CA  1 
ATOM   5647 C C   . ASP B 2 307 ? 149.746 148.373 157.722 1.00 70.04  ?  289 ASP B C   1 
ATOM   5648 O O   . ASP B 2 307 ? 148.645 148.421 157.163 1.00 70.04  ?  289 ASP B O   1 
ATOM   5649 C CB  . ASP B 2 307 ? 149.621 150.192 159.470 1.00 70.04  ?  289 ASP B CB  1 
ATOM   5650 C CG  . ASP B 2 307 ? 150.730 151.085 158.942 1.00 70.04  ?  289 ASP B CG  1 
ATOM   5651 O OD1 . ASP B 2 307 ? 151.666 150.604 158.283 1.00 70.04  ?  289 ASP B OD1 1 
ATOM   5652 O OD2 . ASP B 2 307 ? 150.658 152.305 159.197 1.00 70.04  -1 289 ASP B OD2 1 
ATOM   5653 N N   . ILE B 2 308 ? 150.867 148.063 157.068 1.00 65.37  ?  290 ILE B N   1 
ATOM   5654 C CA  . ILE B 2 308 ? 150.798 147.483 155.732 1.00 65.37  ?  290 ILE B CA  1 
ATOM   5655 C C   . ILE B 2 308 ? 150.236 146.074 155.805 1.00 65.37  ?  290 ILE B C   1 
ATOM   5656 O O   . ILE B 2 308 ? 149.285 145.732 155.095 1.00 65.37  ?  290 ILE B O   1 
ATOM   5657 C CB  . ILE B 2 308 ? 152.179 147.498 155.051 1.00 65.37  ?  290 ILE B CB  1 
ATOM   5658 C CG1 . ILE B 2 308 ? 152.546 148.901 154.596 1.00 65.37  ?  290 ILE B CG1 1 
ATOM   5659 C CG2 . ILE B 2 308 ? 152.179 146.604 153.830 1.00 65.37  ?  290 ILE B CG2 1 
ATOM   5660 C CD1 . ILE B 2 308 ? 153.950 149.008 154.066 1.00 65.37  ?  290 ILE B CD1 1 
ATOM   5661 N N   . LEU B 2 309 ? 150.780 145.253 156.706 1.00 67.62  ?  291 LEU B N   1 
ATOM   5662 C CA  . LEU B 2 309 ? 150.382 143.853 156.796 1.00 67.62  ?  291 LEU B CA  1 
ATOM   5663 C C   . LEU B 2 309 ? 148.997 143.646 157.398 1.00 67.62  ?  291 LEU B C   1 
ATOM   5664 O O   . LEU B 2 309 ? 148.514 142.510 157.401 1.00 67.62  ?  291 LEU B O   1 
ATOM   5665 C CB  . LEU B 2 309 ? 151.410 143.075 157.614 1.00 67.62  ?  291 LEU B CB  1 
ATOM   5666 C CG  . LEU B 2 309 ? 152.768 142.853 156.953 1.00 67.62  ?  291 LEU B CG  1 
ATOM   5667 C CD1 . LEU B 2 309 ? 153.683 142.080 157.877 1.00 67.62  ?  291 LEU B CD1 1 
ATOM   5668 C CD2 . LEU B 2 309 ? 152.611 142.138 155.628 1.00 67.62  ?  291 LEU B CD2 1 
ATOM   5669 N N   . ALA B 2 310 ? 148.347 144.692 157.901 1.00 68.39  ?  292 ALA B N   1 
ATOM   5670 C CA  . ALA B 2 310 ? 147.044 144.570 158.542 1.00 68.39  ?  292 ALA B CA  1 
ATOM   5671 C C   . ALA B 2 310 ? 146.044 145.540 157.934 1.00 68.39  ?  292 ALA B C   1 
ATOM   5672 O O   . ALA B 2 310 ? 145.230 146.142 158.639 1.00 68.39  ?  292 ALA B O   1 
ATOM   5673 C CB  . ALA B 2 310 ? 147.156 144.790 160.046 1.00 68.39  ?  292 ALA B CB  1 
ATOM   5674 N N   . SER B 2 311 ? 146.078 145.705 156.615 1.00 66.96  ?  293 SER B N   1 
ATOM   5675 C CA  . SER B 2 311 ? 145.158 146.596 155.926 1.00 66.96  ?  293 SER B CA  1 
ATOM   5676 C C   . SER B 2 311 ? 144.493 145.864 154.771 1.00 66.96  ?  293 SER B C   1 
ATOM   5677 O O   . SER B 2 311 ? 145.067 144.946 154.180 1.00 66.96  ?  293 SER B O   1 
ATOM   5678 C CB  . SER B 2 311 ? 145.866 147.846 155.404 1.00 66.96  ?  293 SER B CB  1 
ATOM   5679 O OG  . SER B 2 311 ? 146.719 147.531 154.323 1.00 66.96  ?  293 SER B OG  1 
ATOM   5680 N N   . ASP B 2 312 ? 143.268 146.286 154.453 1.00 70.05  ?  294 ASP B N   1 
ATOM   5681 C CA  . ASP B 2 312 ? 142.522 145.664 153.367 1.00 70.05  ?  294 ASP B CA  1 
ATOM   5682 C C   . ASP B 2 312 ? 142.978 146.162 152.004 1.00 70.05  ?  294 ASP B C   1 
ATOM   5683 O O   . ASP B 2 312 ? 142.860 145.436 151.012 1.00 70.05  ?  294 ASP B O   1 
ATOM   5684 C CB  . ASP B 2 312 ? 141.028 145.922 153.548 1.00 70.05  ?  294 ASP B CB  1 
ATOM   5685 C CG  . ASP B 2 312 ? 140.460 145.210 154.757 1.00 70.05  ?  294 ASP B CG  1 
ATOM   5686 O OD1 . ASP B 2 312 ? 140.997 144.144 155.123 1.00 70.05  ?  294 ASP B OD1 1 
ATOM   5687 O OD2 . ASP B 2 312 ? 139.478 145.715 155.342 1.00 70.05  -1 294 ASP B OD2 1 
ATOM   5688 N N   . ALA B 2 313 ? 143.484 147.390 151.934 1.00 61.87  ?  295 ALA B N   1 
ATOM   5689 C CA  . ALA B 2 313 ? 144.040 147.939 150.707 1.00 61.87  ?  295 ALA B CA  1 
ATOM   5690 C C   . ALA B 2 313 ? 145.128 148.925 151.092 1.00 61.87  ?  295 ALA B C   1 
ATOM   5691 O O   . ALA B 2 313 ? 144.874 149.850 151.867 1.00 61.87  ?  295 ALA B O   1 
ATOM   5692 C CB  . ALA B 2 313 ? 142.966 148.622 149.860 1.00 61.87  ?  295 ALA B CB  1 
ATOM   5693 N N   . VAL B 2 314 ? 146.331 148.719 150.555 1.00 58.16  ?  296 VAL B N   1 
ATOM   5694 C CA  . VAL B 2 314 ? 147.492 149.485 150.995 1.00 58.16  ?  296 VAL B CA  1 
ATOM   5695 C C   . VAL B 2 314 ? 147.423 150.917 150.479 1.00 58.16  ?  296 VAL B C   1 
ATOM   5696 O O   . VAL B 2 314 ? 147.819 151.862 151.173 1.00 58.16  ?  296 VAL B O   1 
ATOM   5697 C CB  . VAL B 2 314 ? 148.781 148.770 150.552 1.00 58.16  ?  296 VAL B CB  1 
ATOM   5698 C CG1 . VAL B 2 314 ? 150.014 149.465 151.093 1.00 58.16  ?  296 VAL B CG1 1 
ATOM   5699 C CG2 . VAL B 2 314 ? 148.754 147.332 151.024 1.00 58.16  ?  296 VAL B CG2 1 
ATOM   5700 N N   . ALA B 2 315 ? 146.890 151.103 149.271 1.00 56.78  ?  297 ALA B N   1 
ATOM   5701 C CA  . ALA B 2 315 ? 146.818 152.438 148.690 1.00 56.78  ?  297 ALA B CA  1 
ATOM   5702 C C   . ALA B 2 315 ? 145.782 153.305 149.392 1.00 56.78  ?  297 ALA B C   1 
ATOM   5703 O O   . ALA B 2 315 ? 145.961 154.523 149.485 1.00 56.78  ?  297 ALA B O   1 
ATOM   5704 C CB  . ALA B 2 315 ? 146.517 152.336 147.197 1.00 56.78  ?  297 ALA B CB  1 
ATOM   5705 N N   . VAL B 2 316 ? 144.727 152.694 149.932 1.00 59.01  ?  298 VAL B N   1 
ATOM   5706 C CA  . VAL B 2 316 ? 143.724 153.445 150.680 1.00 59.01  ?  298 VAL B CA  1 
ATOM   5707 C C   . VAL B 2 316 ? 144.298 153.926 152.008 1.00 59.01  ?  298 VAL B C   1 
ATOM   5708 O O   . VAL B 2 316 ? 144.071 155.070 152.418 1.00 59.01  ?  298 VAL B O   1 
ATOM   5709 C CB  . VAL B 2 316 ? 142.464 152.582 150.870 1.00 59.01  ?  298 VAL B CB  1 
ATOM   5710 C CG1 . VAL B 2 316 ? 141.418 153.310 151.686 1.00 59.01  ?  298 VAL B CG1 1 
ATOM   5711 C CG2 . VAL B 2 316 ? 141.896 152.197 149.520 1.00 59.01  ?  298 VAL B CG2 1 
ATOM   5712 N N   . THR B 2 317 ? 145.078 153.074 152.681 1.00 59.37  ?  299 THR B N   1 
ATOM   5713 C CA  . THR B 2 317 ? 145.763 153.471 153.909 1.00 59.37  ?  299 THR B CA  1 
ATOM   5714 C C   . THR B 2 317 ? 146.800 154.557 153.637 1.00 59.37  ?  299 THR B C   1 
ATOM   5715 O O   . THR B 2 317 ? 146.932 155.513 154.416 1.00 59.37  ?  299 THR B O   1 
ATOM   5716 C CB  . THR B 2 317 ? 146.416 152.240 154.543 1.00 59.37  ?  299 THR B CB  1 
ATOM   5717 O OG1 . THR B 2 317 ? 145.416 151.248 154.793 1.00 59.37  ?  299 THR B OG1 1 
ATOM   5718 C CG2 . THR B 2 317 ? 147.095 152.585 155.852 1.00 59.37  ?  299 THR B CG2 1 
ATOM   5719 N N   . PHE B 2 318 ? 147.522 154.432 152.518 1.00 55.72  ?  300 PHE B N   1 
ATOM   5720 C CA  . PHE B 2 318 ? 148.475 155.449 152.081 1.00 55.72  ?  300 PHE B CA  1 
ATOM   5721 C C   . PHE B 2 318 ? 147.792 156.795 151.857 1.00 55.72  ?  300 PHE B C   1 
ATOM   5722 O O   . PHE B 2 318 ? 148.296 157.842 152.283 1.00 55.72  ?  300 PHE B O   1 
ATOM   5723 C CB  . PHE B 2 318 ? 149.159 154.962 150.800 1.00 55.72  ?  300 PHE B CB  1 
ATOM   5724 C CG  . PHE B 2 318 ? 150.213 155.885 150.262 1.00 55.72  ?  300 PHE B CG  1 
ATOM   5725 C CD1 . PHE B 2 318 ? 151.515 155.788 150.703 1.00 55.72  ?  300 PHE B CD1 1 
ATOM   5726 C CD2 . PHE B 2 318 ? 149.913 156.815 149.279 1.00 55.72  ?  300 PHE B CD2 1 
ATOM   5727 C CE1 . PHE B 2 318 ? 152.488 156.620 150.199 1.00 55.72  ?  300 PHE B CE1 1 
ATOM   5728 C CE2 . PHE B 2 318 ? 150.881 157.654 148.784 1.00 55.72  ?  300 PHE B CE2 1 
ATOM   5729 C CZ  . PHE B 2 318 ? 152.170 157.554 149.242 1.00 55.72  ?  300 PHE B CZ  1 
ATOM   5730 N N   . ALA B 2 319 ? 146.636 156.779 151.189 1.00 61.55  ?  301 ALA B N   1 
ATOM   5731 C CA  . ALA B 2 319 ? 145.909 158.012 150.911 1.00 61.55  ?  301 ALA B CA  1 
ATOM   5732 C C   . ALA B 2 319 ? 145.326 158.615 152.179 1.00 61.55  ?  301 ALA B C   1 
ATOM   5733 O O   . ALA B 2 319 ? 145.266 159.840 152.316 1.00 61.55  ?  301 ALA B O   1 
ATOM   5734 C CB  . ALA B 2 319 ? 144.801 157.746 149.898 1.00 61.55  ?  301 ALA B CB  1 
ATOM   5735 N N   . ASP B 2 320 ? 144.885 157.772 153.115 1.00 64.08  ?  302 ASP B N   1 
ATOM   5736 C CA  . ASP B 2 320 ? 144.352 158.286 154.369 1.00 64.08  ?  302 ASP B CA  1 
ATOM   5737 C C   . ASP B 2 320 ? 145.449 158.870 155.244 1.00 64.08  ?  302 ASP B C   1 
ATOM   5738 O O   . ASP B 2 320 ? 145.184 159.776 156.041 1.00 64.08  ?  302 ASP B O   1 
ATOM   5739 C CB  . ASP B 2 320 ? 143.611 157.185 155.123 1.00 64.08  ?  302 ASP B CB  1 
ATOM   5740 C CG  . ASP B 2 320 ? 142.350 156.746 154.414 1.00 64.08  ?  302 ASP B CG  1 
ATOM   5741 O OD1 . ASP B 2 320 ? 141.779 157.562 153.661 1.00 64.08  ?  302 ASP B OD1 1 
ATOM   5742 O OD2 . ASP B 2 320 ? 141.924 155.590 154.613 1.00 64.08  -1 302 ASP B OD2 1 
ATOM   5743 N N   . GLN B 2 321 ? 146.677 158.382 155.107 1.00 64.58  ?  303 GLN B N   1 
ATOM   5744 C CA  . GLN B 2 321 ? 147.751 158.880 155.952 1.00 64.58  ?  303 GLN B CA  1 
ATOM   5745 C C   . GLN B 2 321 ? 148.473 160.092 155.371 1.00 64.58  ?  303 GLN B C   1 
ATOM   5746 O O   . GLN B 2 321 ? 148.858 160.985 156.134 1.00 64.58  ?  303 GLN B O   1 
ATOM   5747 C CB  . GLN B 2 321 ? 148.747 157.754 156.237 1.00 64.58  ?  303 GLN B CB  1 
ATOM   5748 C CG  . GLN B 2 321 ? 149.775 158.075 157.298 1.00 64.58  ?  303 GLN B CG  1 
ATOM   5749 C CD  . GLN B 2 321 ? 150.145 156.865 158.124 1.00 64.58  ?  303 GLN B CD  1 
ATOM   5750 O OE1 . GLN B 2 321 ? 149.449 155.851 158.105 1.00 64.58  ?  303 GLN B OE1 1 
ATOM   5751 N NE2 . GLN B 2 321 ? 151.248 156.961 158.853 1.00 64.58  ?  303 GLN B NE2 1 
ATOM   5752 N N   . ILE B 2 322 ? 148.654 160.182 154.054 1.00 64.36  ?  304 ILE B N   1 
ATOM   5753 C CA  . ILE B 2 322 ? 149.434 161.277 153.488 1.00 64.36  ?  304 ILE B CA  1 
ATOM   5754 C C   . ILE B 2 322 ? 148.578 162.366 152.834 1.00 64.36  ?  304 ILE B C   1 
ATOM   5755 O O   . ILE B 2 322 ? 149.024 163.521 152.771 1.00 64.36  ?  304 ILE B O   1 
ATOM   5756 C CB  . ILE B 2 322 ? 150.514 160.759 152.508 1.00 64.36  ?  304 ILE B CB  1 
ATOM   5757 C CG1 . ILE B 2 322 ? 151.686 161.739 152.428 1.00 64.36  ?  304 ILE B CG1 1 
ATOM   5758 C CG2 . ILE B 2 322 ? 149.967 160.484 151.121 1.00 64.36  ?  304 ILE B CG2 1 
ATOM   5759 C CD1 . ILE B 2 322 ? 152.849 161.233 151.631 1.00 64.36  ?  304 ILE B CD1 1 
ATOM   5760 N N   . PHE B 2 323 ? 147.363 162.064 152.387 1.00 65.33  ?  305 PHE B N   1 
ATOM   5761 C CA  . PHE B 2 323 ? 146.460 163.080 151.861 1.00 65.33  ?  305 PHE B CA  1 
ATOM   5762 C C   . PHE B 2 323 ? 145.420 163.387 152.930 1.00 65.33  ?  305 PHE B C   1 
ATOM   5763 O O   . PHE B 2 323 ? 144.694 162.487 153.363 1.00 65.33  ?  305 PHE B O   1 
ATOM   5764 C CB  . PHE B 2 323 ? 145.779 162.622 150.570 1.00 65.33  ?  305 PHE B CB  1 
ATOM   5765 C CG  . PHE B 2 323 ? 146.729 162.192 149.486 1.00 65.33  ?  305 PHE B CG  1 
ATOM   5766 C CD1 . PHE B 2 323 ? 147.913 162.871 149.264 1.00 65.33  ?  305 PHE B CD1 1 
ATOM   5767 C CD2 . PHE B 2 323 ? 146.421 161.114 148.676 1.00 65.33  ?  305 PHE B CD2 1 
ATOM   5768 C CE1 . PHE B 2 323 ? 148.778 162.469 148.259 1.00 65.33  ?  305 PHE B CE1 1 
ATOM   5769 C CE2 . PHE B 2 323 ? 147.280 160.712 147.673 1.00 65.33  ?  305 PHE B CE2 1 
ATOM   5770 C CZ  . PHE B 2 323 ? 148.458 161.388 147.466 1.00 65.33  ?  305 PHE B CZ  1 
ATOM   5771 N N   . GLY B 2 324 ? 145.363 164.640 153.371 1.00 66.96  ?  306 GLY B N   1 
ATOM   5772 C CA  . GLY B 2 324 ? 144.407 165.009 154.397 1.00 66.96  ?  306 GLY B CA  1 
ATOM   5773 C C   . GLY B 2 324 ? 142.991 164.983 153.869 1.00 66.96  ?  306 GLY B C   1 
ATOM   5774 O O   . GLY B 2 324 ? 142.199 164.106 154.221 1.00 66.96  ?  306 GLY B O   1 
ATOM   5775 N N   . ILE B 2 325 ? 142.673 165.934 153.005 1.00 67.32  ?  307 ILE B N   1 
ATOM   5776 C CA  . ILE B 2 325 ? 141.508 165.850 152.166 1.00 67.32  ?  307 ILE B CA  1 
ATOM   5777 C C   . ILE B 2 325 ? 141.974 165.388 150.791 1.00 67.32  ?  307 ILE B C   1 
ATOM   5778 O O   . ILE B 2 325 ? 143.169 165.262 150.532 1.00 67.32  ?  307 ILE B O   1 
ATOM   5779 C CB  . ILE B 2 325 ? 140.730 167.185 152.107 1.00 67.32  ?  307 ILE B CB  1 
ATOM   5780 C CG1 . ILE B 2 325 ? 141.657 168.339 151.735 1.00 67.32  ?  307 ILE B CG1 1 
ATOM   5781 C CG2 . ILE B 2 325 ? 140.051 167.458 153.437 1.00 67.32  ?  307 ILE B CG2 1 
ATOM   5782 C CD1 . ILE B 2 325 ? 140.931 169.641 151.524 1.00 67.32  ?  307 ILE B CD1 1 
ATOM   5783 N N   . PHE B 2 326 ? 141.010 165.092 149.913 1.00 66.01  ?  308 PHE B N   1 
ATOM   5784 C CA  . PHE B 2 326 ? 141.220 164.421 148.622 1.00 66.01  ?  308 PHE B CA  1 
ATOM   5785 C C   . PHE B 2 326 ? 141.888 163.060 148.811 1.00 66.01  ?  308 PHE B C   1 
ATOM   5786 O O   . PHE B 2 326 ? 142.834 162.705 148.108 1.00 66.01  ?  308 PHE B O   1 
ATOM   5787 C CB  . PHE B 2 326 ? 142.012 165.277 147.622 1.00 66.01  ?  308 PHE B CB  1 
ATOM   5788 C CG  . PHE B 2 326 ? 141.732 166.743 147.714 1.00 66.01  ?  308 PHE B CG  1 
ATOM   5789 C CD1 . PHE B 2 326 ? 140.508 167.256 147.324 1.00 66.01  ?  308 PHE B CD1 1 
ATOM   5790 C CD2 . PHE B 2 326 ? 142.709 167.615 148.163 1.00 66.01  ?  308 PHE B CD2 1 
ATOM   5791 C CE1 . PHE B 2 326 ? 140.255 168.610 147.402 1.00 66.01  ?  308 PHE B CE1 1 
ATOM   5792 C CE2 . PHE B 2 326 ? 142.464 168.969 148.240 1.00 66.01  ?  308 PHE B CE2 1 
ATOM   5793 C CZ  . PHE B 2 326 ? 141.236 169.467 147.858 1.00 66.01  ?  308 PHE B CZ  1 
ATOM   5794 N N   . ASN B 2 327 ? 141.388 162.295 149.776 1.00 63.44  ?  309 ASN B N   1 
ATOM   5795 C CA  . ASN B 2 327 ? 141.810 160.915 149.953 1.00 63.44  ?  309 ASN B CA  1 
ATOM   5796 C C   . ASN B 2 327 ? 140.885 159.933 149.247 1.00 63.44  ?  309 ASN B C   1 
ATOM   5797 O O   . ASN B 2 327 ? 141.152 158.729 149.261 1.00 63.44  ?  309 ASN B O   1 
ATOM   5798 C CB  . ASN B 2 327 ? 141.915 160.575 151.444 1.00 63.44  ?  309 ASN B CB  1 
ATOM   5799 C CG  . ASN B 2 327 ? 140.585 160.642 152.154 1.00 63.44  ?  309 ASN B CG  1 
ATOM   5800 O OD1 . ASN B 2 327 ? 139.729 161.453 151.813 1.00 63.44  ?  309 ASN B OD1 1 
ATOM   5801 N ND2 . ASN B 2 327 ? 140.405 159.790 153.153 1.00 63.44  ?  309 ASN B ND2 1 
ATOM   5802 N N   . TRP B 2 328 ? 139.809 160.425 148.632 1.00 59.75  ?  310 TRP B N   1 
ATOM   5803 C CA  . TRP B 2 328 ? 138.921 159.643 147.781 1.00 59.75  ?  310 TRP B CA  1 
ATOM   5804 C C   . TRP B 2 328 ? 139.443 159.514 146.355 1.00 59.75  ?  310 TRP B C   1 
ATOM   5805 O O   . TRP B 2 328 ? 138.914 158.694 145.583 1.00 59.75  ?  310 TRP B O   1 
ATOM   5806 C CB  . TRP B 2 328 ? 137.531 160.284 147.770 1.00 59.75  ?  310 TRP B CB  1 
ATOM   5807 C CG  . TRP B 2 328 ? 137.568 161.787 147.749 1.00 59.75  ?  310 TRP B CG  1 
ATOM   5808 C CD1 . TRP B 2 328 ? 137.564 162.624 148.827 1.00 59.75  ?  310 TRP B CD1 1 
ATOM   5809 C CD2 . TRP B 2 328 ? 137.617 162.628 146.592 1.00 59.75  ?  310 TRP B CD2 1 
ATOM   5810 N NE1 . TRP B 2 328 ? 137.612 163.930 148.413 1.00 59.75  ?  310 TRP B NE1 1 
ATOM   5811 C CE2 . TRP B 2 328 ? 137.643 163.960 147.045 1.00 59.75  ?  310 TRP B CE2 1 
ATOM   5812 C CE3 . TRP B 2 328 ? 137.640 162.383 145.217 1.00 59.75  ?  310 TRP B CE3 1 
ATOM   5813 C CZ2 . TRP B 2 328 ? 137.692 165.042 146.174 1.00 59.75  ?  310 TRP B CZ2 1 
ATOM   5814 C CZ3 . TRP B 2 328 ? 137.686 163.458 144.355 1.00 59.75  ?  310 TRP B CZ3 1 
ATOM   5815 C CH2 . TRP B 2 328 ? 137.714 164.771 144.835 1.00 59.75  ?  310 TRP B CH2 1 
ATOM   5816 N N   . ILE B 2 329 ? 140.468 160.305 146.016 1.00 57.05  ?  311 ILE B N   1 
ATOM   5817 C CA  . ILE B 2 329 ? 141.104 160.276 144.701 1.00 57.05  ?  311 ILE B CA  1 
ATOM   5818 C C   . ILE B 2 329 ? 141.665 158.892 144.404 1.00 57.05  ?  311 ILE B C   1 
ATOM   5819 O O   . ILE B 2 329 ? 141.510 158.367 143.297 1.00 57.05  ?  311 ILE B O   1 
ATOM   5820 C CB  . ILE B 2 329 ? 142.195 161.364 144.640 1.00 57.05  ?  311 ILE B CB  1 
ATOM   5821 C CG1 . ILE B 2 329 ? 141.562 162.756 144.566 1.00 57.05  ?  311 ILE B CG1 1 
ATOM   5822 C CG2 . ILE B 2 329 ? 143.178 161.129 143.494 1.00 57.05  ?  311 ILE B CG2 1 
ATOM   5823 C CD1 . ILE B 2 329 ? 141.098 163.156 143.186 1.00 57.05  ?  311 ILE B CD1 1 
ATOM   5824 N N   . ILE B 2 330 ? 142.269 158.256 145.401 1.00 54.12  ?  312 ILE B N   1 
ATOM   5825 C CA  . ILE B 2 330 ? 142.902 156.951 145.223 1.00 54.12  ?  312 ILE B CA  1 
ATOM   5826 C C   . ILE B 2 330 ? 141.881 155.816 145.064 1.00 54.12  ?  312 ILE B C   1 
ATOM   5827 O O   . ILE B 2 330 ? 142.083 154.987 144.164 1.00 54.12  ?  312 ILE B O   1 
ATOM   5828 C CB  . ILE B 2 330 ? 143.925 156.705 146.351 1.00 54.12  ?  312 ILE B CB  1 
ATOM   5829 C CG1 . ILE B 2 330 ? 145.102 157.669 146.200 1.00 54.12  ?  312 ILE B CG1 1 
ATOM   5830 C CG2 . ILE B 2 330 ? 144.433 155.287 146.355 1.00 54.12  ?  312 ILE B CG2 1 
ATOM   5831 C CD1 . ILE B 2 330 ? 145.780 157.610 144.854 1.00 54.12  ?  312 ILE B CD1 1 
ATOM   5832 N N   . PRO B 2 331 ? 140.777 155.712 145.835 1.00 52.71  ?  313 PRO B N   1 
ATOM   5833 C CA  . PRO B 2 331 ? 139.760 154.707 145.461 1.00 52.71  ?  313 PRO B CA  1 
ATOM   5834 C C   . PRO B 2 331 ? 139.077 154.978 144.129 1.00 52.71  ?  313 PRO B C   1 
ATOM   5835 O O   . PRO B 2 331 ? 138.747 154.018 143.411 1.00 52.71  ?  313 PRO B O   1 
ATOM   5836 C CB  . PRO B 2 331 ? 138.761 154.769 146.623 1.00 52.71  ?  313 PRO B CB  1 
ATOM   5837 C CG  . PRO B 2 331 ? 139.545 155.225 147.750 1.00 52.71  ?  313 PRO B CG  1 
ATOM   5838 C CD  . PRO B 2 331 ? 140.475 156.236 147.185 1.00 52.71  ?  313 PRO B CD  1 
ATOM   5839 N N   . LEU B 2 332 ? 138.878 156.252 143.766 1.00 51.42  ?  314 LEU B N   1 
ATOM   5840 C CA  . LEU B 2 332 ? 138.363 156.565 142.434 1.00 51.42  ?  314 LEU B CA  1 
ATOM   5841 C C   . LEU B 2 332 ? 139.332 156.108 141.345 1.00 51.42  ?  314 LEU B C   1 
ATOM   5842 O O   . LEU B 2 332 ? 138.915 155.585 140.304 1.00 51.42  ?  314 LEU B O   1 
ATOM   5843 C CB  . LEU B 2 332 ? 138.097 158.064 142.328 1.00 51.42  ?  314 LEU B CB  1 
ATOM   5844 C CG  . LEU B 2 332 ? 137.460 158.573 141.038 1.00 51.42  ?  314 LEU B CG  1 
ATOM   5845 C CD1 . LEU B 2 332 ? 136.056 158.017 140.888 1.00 51.42  ?  314 LEU B CD1 1 
ATOM   5846 C CD2 . LEU B 2 332 ? 137.454 160.089 141.012 1.00 51.42  ?  314 LEU B CD2 1 
ATOM   5847 N N   . SER B 2 333 ? 140.632 156.246 141.600 1.00 50.99  ?  315 SER B N   1 
ATOM   5848 C CA  . SER B 2 333 ? 141.653 155.796 140.665 1.00 50.99  ?  315 SER B CA  1 
ATOM   5849 C C   . SER B 2 333 ? 141.710 154.279 140.562 1.00 50.99  ?  315 SER B C   1 
ATOM   5850 O O   . SER B 2 333 ? 141.991 153.748 139.483 1.00 50.99  ?  315 SER B O   1 
ATOM   5851 C CB  . SER B 2 333 ? 143.005 156.335 141.101 1.00 50.99  ?  315 SER B CB  1 
ATOM   5852 O OG  . SER B 2 333 ? 143.037 157.744 141.004 1.00 50.99  ?  315 SER B OG  1 
ATOM   5853 N N   . VAL B 2 334 ? 141.465 153.575 141.670 1.00 49.69  ?  316 VAL B N   1 
ATOM   5854 C CA  . VAL B 2 334 ? 141.392 152.115 141.634 1.00 49.69  ?  316 VAL B CA  1 
ATOM   5855 C C   . VAL B 2 334 ? 140.214 151.666 140.776 1.00 49.69  ?  316 VAL B C   1 
ATOM   5856 O O   . VAL B 2 334 ? 140.331 150.729 139.969 1.00 49.69  ?  316 VAL B O   1 
ATOM   5857 C CB  . VAL B 2 334 ? 141.310 151.552 143.067 1.00 49.69  ?  316 VAL B CB  1 
ATOM   5858 C CG1 . VAL B 2 334 ? 141.011 150.065 143.067 1.00 49.69  ?  316 VAL B CG1 1 
ATOM   5859 C CG2 . VAL B 2 334 ? 142.600 151.799 143.800 1.00 49.69  ?  316 VAL B CG2 1 
ATOM   5860 N N   . ALA B 2 335 ? 139.076 152.357 140.908 1.00 49.12  ?  317 ALA B N   1 
ATOM   5861 C CA  . ALA B 2 335 ? 137.916 152.062 140.068 1.00 49.12  ?  317 ALA B CA  1 
ATOM   5862 C C   . ALA B 2 335 ? 138.204 152.316 138.589 1.00 49.12  ?  317 ALA B C   1 
ATOM   5863 O O   . ALA B 2 335 ? 137.820 151.513 137.727 1.00 49.12  ?  317 ALA B O   1 
ATOM   5864 C CB  . ALA B 2 335 ? 136.719 152.889 140.528 1.00 49.12  ?  317 ALA B CB  1 
ATOM   5865 N N   . LEU B 2 336 ? 138.907 153.410 138.280 1.00 47.26  ?  318 LEU B N   1 
ATOM   5866 C CA  . LEU B 2 336 ? 139.271 153.685 136.890 1.00 47.26  ?  318 LEU B CA  1 
ATOM   5867 C C   . LEU B 2 336 ? 140.269 152.665 136.345 1.00 47.26  ?  318 LEU B C   1 
ATOM   5868 O O   . LEU B 2 336 ? 140.214 152.318 135.160 1.00 47.26  ?  318 LEU B O   1 
ATOM   5869 C CB  . LEU B 2 336 ? 139.839 155.097 136.759 1.00 47.26  ?  318 LEU B CB  1 
ATOM   5870 C CG  . LEU B 2 336 ? 138.912 156.269 137.091 1.00 47.26  ?  318 LEU B CG  1 
ATOM   5871 C CD1 . LEU B 2 336 ? 139.538 157.582 136.673 1.00 47.26  ?  318 LEU B CD1 1 
ATOM   5872 C CD2 . LEU B 2 336 ? 137.539 156.103 136.469 1.00 47.26  ?  318 LEU B CD2 1 
ATOM   5873 N N   . SER B 2 337 ? 141.161 152.157 137.197 1.00 47.35  ?  319 SER B N   1 
ATOM   5874 C CA  . SER B 2 337 ? 142.100 151.120 136.778 1.00 47.35  ?  319 SER B CA  1 
ATOM   5875 C C   . SER B 2 337 ? 141.386 149.811 136.450 1.00 47.35  ?  319 SER B C   1 
ATOM   5876 O O   . SER B 2 337 ? 141.723 149.142 135.463 1.00 47.35  ?  319 SER B O   1 
ATOM   5877 C CB  . SER B 2 337 ? 143.147 150.907 137.869 1.00 47.35  ?  319 SER B CB  1 
ATOM   5878 O OG  . SER B 2 337 ? 144.054 149.883 137.517 1.00 47.35  ?  319 SER B OG  1 
ATOM   5879 N N   . CYS B 2 338 ? 140.390 149.435 137.257 1.00 47.30  ?  320 CYS B N   1 
ATOM   5880 C CA  . CYS B 2 338 ? 139.615 148.236 136.937 1.00 47.30  ?  320 CYS B CA  1 
ATOM   5881 C C   . CYS B 2 338 ? 138.769 148.421 135.681 1.00 47.30  ?  320 CYS B C   1 
ATOM   5882 O O   . CYS B 2 338 ? 138.613 147.473 134.895 1.00 47.30  ?  320 CYS B O   1 
ATOM   5883 C CB  . CYS B 2 338 ? 138.734 147.830 138.116 1.00 47.30  ?  320 CYS B CB  1 
ATOM   5884 S SG  . CYS B 2 338 ? 139.609 147.606 139.674 1.00 47.30  ?  320 CYS B SG  1 
ATOM   5885 N N   . PHE B 2 339 ? 138.243 149.631 135.463 1.00 44.72  ?  321 PHE B N   1 
ATOM   5886 C CA  . PHE B 2 339 ? 137.534 149.920 134.220 1.00 44.72  ?  321 PHE B CA  1 
ATOM   5887 C C   . PHE B 2 339 ? 138.456 149.845 133.008 1.00 44.72  ?  321 PHE B C   1 
ATOM   5888 O O   . PHE B 2 339 ? 138.020 149.449 131.923 1.00 44.72  ?  321 PHE B O   1 
ATOM   5889 C CB  . PHE B 2 339 ? 136.881 151.296 134.297 1.00 44.72  ?  321 PHE B CB  1 
ATOM   5890 C CG  . PHE B 2 339 ? 135.804 151.513 133.279 1.00 44.72  ?  321 PHE B CG  1 
ATOM   5891 C CD1 . PHE B 2 339 ? 134.513 151.093 133.527 1.00 44.72  ?  321 PHE B CD1 1 
ATOM   5892 C CD2 . PHE B 2 339 ? 136.081 152.140 132.077 1.00 44.72  ?  321 PHE B CD2 1 
ATOM   5893 C CE1 . PHE B 2 339 ? 133.518 151.290 132.595 1.00 44.72  ?  321 PHE B CE1 1 
ATOM   5894 C CE2 . PHE B 2 339 ? 135.090 152.339 131.142 1.00 44.72  ?  321 PHE B CE2 1 
ATOM   5895 C CZ  . PHE B 2 339 ? 133.808 151.916 131.402 1.00 44.72  ?  321 PHE B CZ  1 
ATOM   5896 N N   . GLY B 2 340 ? 139.726 150.214 133.171 1.00 43.42  ?  322 GLY B N   1 
ATOM   5897 C CA  . GLY B 2 340 ? 140.672 150.060 132.081 1.00 43.42  ?  322 GLY B CA  1 
ATOM   5898 C C   . GLY B 2 340 ? 141.059 148.619 131.816 1.00 43.42  ?  322 GLY B C   1 
ATOM   5899 O O   . GLY B 2 340 ? 141.308 148.244 130.668 1.00 43.42  ?  322 GLY B O   1 
ATOM   5900 N N   . GLY B 2 341 ? 141.124 147.796 132.863 1.00 43.59  ?  323 GLY B N   1 
ATOM   5901 C CA  . GLY B 2 341 ? 141.472 146.396 132.667 1.00 43.59  ?  323 GLY B CA  1 
ATOM   5902 C C   . GLY B 2 341 ? 140.367 145.560 132.046 1.00 43.59  ?  323 GLY B C   1 
ATOM   5903 O O   . GLY B 2 341 ? 140.646 144.630 131.271 1.00 43.59  ?  323 GLY B O   1 
ATOM   5904 N N   . LEU B 2 342 ? 139.106 145.868 132.380 1.00 41.82  ?  324 LEU B N   1 
ATOM   5905 C CA  . LEU B 2 342 ? 137.982 145.088 131.862 1.00 41.82  ?  324 LEU B CA  1 
ATOM   5906 C C   . LEU B 2 342 ? 137.834 145.212 130.346 1.00 41.82  ?  324 LEU B C   1 
ATOM   5907 O O   . LEU B 2 342 ? 137.473 144.234 129.678 1.00 41.82  ?  324 LEU B O   1 
ATOM   5908 C CB  . LEU B 2 342 ? 136.692 145.515 132.560 1.00 41.82  ?  324 LEU B CB  1 
ATOM   5909 C CG  . LEU B 2 342 ? 135.453 144.665 132.282 1.00 41.82  ?  324 LEU B CG  1 
ATOM   5910 C CD1 . LEU B 2 342 ? 135.710 143.214 132.613 1.00 41.82  ?  324 LEU B CD1 1 
ATOM   5911 C CD2 . LEU B 2 342 ? 134.276 145.181 133.061 1.00 41.82  ?  324 LEU B CD2 1 
ATOM   5912 N N   . ASN B 2 343 ? 138.142 146.387 129.791 1.00 41.34  ?  325 ASN B N   1 
ATOM   5913 C CA  . ASN B 2 343 ? 138.049 146.606 128.350 1.00 41.34  ?  325 ASN B CA  1 
ATOM   5914 C C   . ASN B 2 343 ? 139.052 145.746 127.582 1.00 41.34  ?  325 ASN B C   1 
ATOM   5915 O O   . ASN B 2 343 ? 138.707 145.125 126.564 1.00 41.34  ?  325 ASN B O   1 
ATOM   5916 C CB  . ASN B 2 343 ? 138.265 148.092 128.063 1.00 41.34  ?  325 ASN B CB  1 
ATOM   5917 C CG  . ASN B 2 343 ? 138.001 148.461 126.625 1.00 41.34  ?  325 ASN B CG  1 
ATOM   5918 O OD1 . ASN B 2 343 ? 136.880 148.350 126.140 1.00 41.34  ?  325 ASN B OD1 1 
ATOM   5919 N ND2 . ASN B 2 343 ? 139.033 148.917 125.937 1.00 41.34  ?  325 ASN B ND2 1 
ATOM   5920 N N   . ALA B 2 344 ? 140.292 145.679 128.076 1.00 41.29  ?  326 ALA B N   1 
ATOM   5921 C CA  . ALA B 2 344 ? 141.320 144.862 127.443 1.00 41.29  ?  326 ALA B CA  1 
ATOM   5922 C C   . ALA B 2 344 ? 140.996 143.379 127.551 1.00 41.29  ?  326 ALA B C   1 
ATOM   5923 O O   . ALA B 2 344 ? 141.220 142.618 126.595 1.00 41.29  ?  326 ALA B O   1 
ATOM   5924 C CB  . ALA B 2 344 ? 142.679 145.158 128.072 1.00 41.29  ?  326 ALA B CB  1 
ATOM   5925 N N   . SER B 2 345 ? 140.450 142.957 128.701 1.00 41.12  ?  327 SER B N   1 
ATOM   5926 C CA  . SER B 2 345 ? 140.034 141.564 128.856 1.00 41.12  ?  327 SER B CA  1 
ATOM   5927 C C   . SER B 2 345 ? 138.916 141.199 127.886 1.00 41.12  ?  327 SER B C   1 
ATOM   5928 O O   . SER B 2 345 ? 138.932 140.109 127.295 1.00 41.12  ?  327 SER B O   1 
ATOM   5929 C CB  . SER B 2 345 ? 139.594 141.309 130.294 1.00 41.12  ?  327 SER B CB  1 
ATOM   5930 O OG  . SER B 2 345 ? 140.703 141.309 131.167 1.00 41.12  ?  327 SER B OG  1 
ATOM   5931 N N   . ILE B 2 346 ? 137.966 142.117 127.679 1.00 39.41  ?  328 ILE B N   1 
ATOM   5932 C CA  . ILE B 2 346 ? 136.847 141.879 126.768 1.00 39.41  ?  328 ILE B CA  1 
ATOM   5933 C C   . ILE B 2 346 ? 137.334 141.744 125.328 1.00 39.41  ?  328 ILE B C   1 
ATOM   5934 O O   . ILE B 2 346 ? 136.931 140.815 124.610 1.00 39.41  ?  328 ILE B O   1 
ATOM   5935 C CB  . ILE B 2 346 ? 135.804 143.004 126.930 1.00 39.41  ?  328 ILE B CB  1 
ATOM   5936 C CG1 . ILE B 2 346 ? 134.910 142.723 128.136 1.00 39.41  ?  328 ILE B CG1 1 
ATOM   5937 C CG2 . ILE B 2 346 ? 134.952 143.180 125.684 1.00 39.41  ?  328 ILE B CG2 1 
ATOM   5938 C CD1 . ILE B 2 346 ? 133.922 143.818 128.429 1.00 39.41  ?  328 ILE B CD1 1 
ATOM   5939 N N   . VAL B 2 347 ? 138.242 142.633 124.905 1.00 38.38  ?  329 VAL B N   1 
ATOM   5940 C CA  . VAL B 2 347 ? 138.757 142.600 123.534 1.00 38.38  ?  329 VAL B CA  1 
ATOM   5941 C C   . VAL B 2 347 ? 139.546 141.317 123.273 1.00 38.38  ?  329 VAL B C   1 
ATOM   5942 O O   . VAL B 2 347 ? 139.350 140.650 122.240 1.00 38.38  ?  329 VAL B O   1 
ATOM   5943 C CB  . VAL B 2 347 ? 139.602 143.858 123.257 1.00 38.38  ?  329 VAL B CB  1 
ATOM   5944 C CG1 . VAL B 2 347 ? 140.339 143.745 121.936 1.00 38.38  ?  329 VAL B CG1 1 
ATOM   5945 C CG2 . VAL B 2 347 ? 138.724 145.083 123.247 1.00 38.38  ?  329 VAL B CG2 1 
ATOM   5946 N N   . ALA B 2 348 ? 140.397 140.919 124.228 1.00 38.65  ?  330 ALA B N   1 
ATOM   5947 C CA  . ALA B 2 348 ? 141.202 139.713 124.052 1.00 38.65  ?  330 ALA B CA  1 
ATOM   5948 C C   . ALA B 2 348 ? 140.343 138.451 124.021 1.00 38.65  ?  330 ALA B C   1 
ATOM   5949 O O   . ALA B 2 348 ? 140.568 137.569 123.179 1.00 38.65  ?  330 ALA B O   1 
ATOM   5950 C CB  . ALA B 2 348 ? 142.250 139.622 125.157 1.00 38.65  ?  330 ALA B CB  1 
ATOM   5951 N N   . ALA B 2 349 ? 139.343 138.358 124.908 1.00 39.32  ?  331 ALA B N   1 
ATOM   5952 C CA  . ALA B 2 349 ? 138.486 137.175 124.935 1.00 39.32  ?  331 ALA B CA  1 
ATOM   5953 C C   . ALA B 2 349 ? 137.637 137.062 123.674 1.00 39.32  ?  331 ALA B C   1 
ATOM   5954 O O   . ALA B 2 349 ? 137.450 135.956 123.144 1.00 39.32  ?  331 ALA B O   1 
ATOM   5955 C CB  . ALA B 2 349 ? 137.599 137.200 126.175 1.00 39.32  ?  331 ALA B CB  1 
ATOM   5956 N N   . SER B 2 350 ? 137.144 138.197 123.161 1.00 40.58  ?  332 SER B N   1 
ATOM   5957 C CA  . SER B 2 350 ? 136.346 138.167 121.939 1.00 40.58  ?  332 SER B CA  1 
ATOM   5958 C C   . SER B 2 350 ? 137.178 137.742 120.736 1.00 40.58  ?  332 SER B C   1 
ATOM   5959 O O   . SER B 2 350 ? 136.708 136.962 119.898 1.00 40.58  ?  332 SER B O   1 
ATOM   5960 C CB  . SER B 2 350 ? 135.719 139.532 121.688 1.00 40.58  ?  332 SER B CB  1 
ATOM   5961 O OG  . SER B 2 350 ? 136.706 140.545 121.703 1.00 40.58  ?  332 SER B OG  1 
ATOM   5962 N N   . ARG B 2 351 ? 138.429 138.207 120.651 1.00 40.32  ?  333 ARG B N   1 
ATOM   5963 C CA  . ARG B 2 351 ? 139.251 137.817 119.507 1.00 40.32  ?  333 ARG B CA  1 
ATOM   5964 C C   . ARG B 2 351 ? 139.691 136.359 119.596 1.00 40.32  ?  333 ARG B C   1 
ATOM   5965 O O   . ARG B 2 351 ? 139.799 135.679 118.562 1.00 40.32  ?  333 ARG B O   1 
ATOM   5966 C CB  . ARG B 2 351 ? 140.459 138.740 119.384 1.00 40.32  ?  333 ARG B CB  1 
ATOM   5967 C CG  . ARG B 2 351 ? 140.280 139.841 118.358 1.00 40.32  ?  333 ARG B CG  1 
ATOM   5968 C CD  . ARG B 2 351 ? 139.258 140.849 118.827 1.00 40.32  ?  333 ARG B CD  1 
ATOM   5969 N NE  . ARG B 2 351 ? 139.036 141.927 117.877 1.00 40.32  ?  333 ARG B NE  1 
ATOM   5970 C CZ  . ARG B 2 351 ? 138.195 142.931 118.087 1.00 40.32  ?  333 ARG B CZ  1 
ATOM   5971 N NH1 . ARG B 2 351 ? 137.502 142.990 119.212 1.00 40.32  1  333 ARG B NH1 1 
ATOM   5972 N NH2 . ARG B 2 351 ? 138.049 143.875 117.174 1.00 40.32  ?  333 ARG B NH2 1 
ATOM   5973 N N   . LEU B 2 352 ? 139.906 135.857 120.816 1.00 40.11  ?  334 LEU B N   1 
ATOM   5974 C CA  . LEU B 2 352 ? 140.212 134.441 121.004 1.00 40.11  ?  334 LEU B CA  1 
ATOM   5975 C C   . LEU B 2 352 ? 139.049 133.553 120.571 1.00 40.11  ?  334 LEU B C   1 
ATOM   5976 O O   . LEU B 2 352 ? 139.247 132.553 119.868 1.00 40.11  ?  334 LEU B O   1 
ATOM   5977 C CB  . LEU B 2 352 ? 140.572 134.181 122.465 1.00 40.11  ?  334 LEU B CB  1 
ATOM   5978 C CG  . LEU B 2 352 ? 140.490 132.738 122.959 1.00 40.11  ?  334 LEU B CG  1 
ATOM   5979 C CD1 . LEU B 2 352 ? 141.683 131.938 122.487 1.00 40.11  ?  334 LEU B CD1 1 
ATOM   5980 C CD2 . LEU B 2 352 ? 140.390 132.714 124.462 1.00 40.11  ?  334 LEU B CD2 1 
ATOM   5981 N N   . PHE B 2 353 ? 137.822 133.910 120.969 1.00 42.22  ?  335 PHE B N   1 
ATOM   5982 C CA  . PHE B 2 353 ? 136.668 133.107 120.568 1.00 42.22  ?  335 PHE B CA  1 
ATOM   5983 C C   . PHE B 2 353 ? 136.378 133.233 119.075 1.00 42.22  ?  335 PHE B C   1 
ATOM   5984 O O   . PHE B 2 353 ? 135.889 132.277 118.462 1.00 42.22  ?  335 PHE B O   1 
ATOM   5985 C CB  . PHE B 2 353 ? 135.440 133.497 121.387 1.00 42.22  ?  335 PHE B CB  1 
ATOM   5986 C CG  . PHE B 2 353 ? 135.588 133.241 122.858 1.00 42.22  ?  335 PHE B CG  1 
ATOM   5987 C CD1 . PHE B 2 353 ? 136.365 132.191 123.320 1.00 42.22  ?  335 PHE B CD1 1 
ATOM   5988 C CD2 . PHE B 2 353 ? 134.949 134.052 123.781 1.00 42.22  ?  335 PHE B CD2 1 
ATOM   5989 C CE1 . PHE B 2 353 ? 136.508 131.960 124.673 1.00 42.22  ?  335 PHE B CE1 1 
ATOM   5990 C CE2 . PHE B 2 353 ? 135.089 133.825 125.133 1.00 42.22  ?  335 PHE B CE2 1 
ATOM   5991 C CZ  . PHE B 2 353 ? 135.869 132.777 125.579 1.00 42.22  ?  335 PHE B CZ  1 
ATOM   5992 N N   . PHE B 2 354 ? 136.709 134.383 118.477 1.00 43.84  ?  336 PHE B N   1 
ATOM   5993 C CA  . PHE B 2 354 ? 136.615 134.556 117.029 1.00 43.84  ?  336 PHE B CA  1 
ATOM   5994 C C   . PHE B 2 354 ? 137.526 133.580 116.291 1.00 43.84  ?  336 PHE B C   1 
ATOM   5995 O O   . PHE B 2 354 ? 137.100 132.903 115.344 1.00 43.84  ?  336 PHE B O   1 
ATOM   5996 C CB  . PHE B 2 354 ? 136.965 136.008 116.685 1.00 43.84  ?  336 PHE B CB  1 
ATOM   5997 C CG  . PHE B 2 354 ? 136.964 136.326 115.216 1.00 43.84  ?  336 PHE B CG  1 
ATOM   5998 C CD1 . PHE B 2 354 ? 135.795 136.684 114.579 1.00 43.84  ?  336 PHE B CD1 1 
ATOM   5999 C CD2 . PHE B 2 354 ? 138.143 136.321 114.483 1.00 43.84  ?  336 PHE B CD2 1 
ATOM   6000 C CE1 . PHE B 2 354 ? 135.792 136.993 113.240 1.00 43.84  ?  336 PHE B CE1 1 
ATOM   6001 C CE2 . PHE B 2 354 ? 138.140 136.624 113.138 1.00 43.84  ?  336 PHE B CE2 1 
ATOM   6002 C CZ  . PHE B 2 354 ? 136.962 136.960 112.519 1.00 43.84  ?  336 PHE B CZ  1 
ATOM   6003 N N   . VAL B 2 355 ? 138.789 133.493 116.719 1.00 44.63  ?  337 VAL B N   1 
ATOM   6004 C CA  . VAL B 2 355 ? 139.744 132.608 116.051 1.00 44.63  ?  337 VAL B CA  1 
ATOM   6005 C C   . VAL B 2 355 ? 139.385 131.142 116.281 1.00 44.63  ?  337 VAL B C   1 
ATOM   6006 O O   . VAL B 2 355 ? 139.469 130.315 115.359 1.00 44.63  ?  337 VAL B O   1 
ATOM   6007 C CB  . VAL B 2 355 ? 141.171 132.943 116.520 1.00 44.63  ?  337 VAL B CB  1 
ATOM   6008 C CG1 . VAL B 2 355 ? 142.179 131.926 116.024 1.00 44.63  ?  337 VAL B CG1 1 
ATOM   6009 C CG2 . VAL B 2 355 ? 141.543 134.313 116.028 1.00 44.63  ?  337 VAL B CG2 1 
ATOM   6010 N N   . GLY B 2 356 ? 138.941 130.804 117.497 1.00 46.03  ?  338 GLY B N   1 
ATOM   6011 C CA  . GLY B 2 356 ? 138.484 129.450 117.766 1.00 46.03  ?  338 GLY B CA  1 
ATOM   6012 C C   . GLY B 2 356 ? 137.264 129.050 116.961 1.00 46.03  ?  338 GLY B C   1 
ATOM   6013 O O   . GLY B 2 356 ? 137.113 127.883 116.598 1.00 46.03  ?  338 GLY B O   1 
ATOM   6014 N N   . SER B 2 357 ? 136.387 130.007 116.657 1.00 48.06  ?  339 SER B N   1 
ATOM   6015 C CA  . SER B 2 357 ? 135.274 129.716 115.762 1.00 48.06  ?  339 SER B CA  1 
ATOM   6016 C C   . SER B 2 357 ? 135.746 129.534 114.329 1.00 48.06  ?  339 SER B C   1 
ATOM   6017 O O   . SER B 2 357 ? 135.209 128.697 113.596 1.00 48.06  ?  339 SER B O   1 
ATOM   6018 C CB  . SER B 2 357 ? 134.242 130.830 115.825 1.00 48.06  ?  339 SER B CB  1 
ATOM   6019 O OG  . SER B 2 357 ? 133.154 130.531 114.974 1.00 48.06  ?  339 SER B OG  1 
ATOM   6020 N N   . ARG B 2 358 ? 136.732 130.325 113.906 1.00 48.97  ?  340 ARG B N   1 
ATOM   6021 C CA  . ARG B 2 358 ? 137.228 130.224 112.538 1.00 48.97  ?  340 ARG B CA  1 
ATOM   6022 C C   . ARG B 2 358 ? 137.986 128.925 112.295 1.00 48.97  ?  340 ARG B C   1 
ATOM   6023 O O   . ARG B 2 358 ? 138.046 128.448 111.157 1.00 48.97  ?  340 ARG B O   1 
ATOM   6024 C CB  . ARG B 2 358 ? 138.122 131.419 112.224 1.00 48.97  ?  340 ARG B CB  1 
ATOM   6025 C CG  . ARG B 2 358 ? 138.296 131.708 110.757 1.00 48.97  ?  340 ARG B CG  1 
ATOM   6026 C CD  . ARG B 2 358 ? 139.109 132.962 110.566 1.00 48.97  ?  340 ARG B CD  1 
ATOM   6027 N NE  . ARG B 2 358 ? 140.397 132.866 111.241 1.00 48.97  ?  340 ARG B NE  1 
ATOM   6028 C CZ  . ARG B 2 358 ? 141.245 133.877 111.372 1.00 48.97  ?  340 ARG B CZ  1 
ATOM   6029 N NH1 . ARG B 2 358 ? 140.941 135.064 110.875 1.00 48.97  1  340 ARG B NH1 1 
ATOM   6030 N NH2 . ARG B 2 358 ? 142.396 133.701 112.000 1.00 48.97  ?  340 ARG B NH2 1 
ATOM   6031 N N   . GLU B 2 359 ? 138.552 128.329 113.338 1.00 52.41  ?  341 GLU B N   1 
ATOM   6032 C CA  . GLU B 2 359 ? 139.401 127.158 113.167 1.00 52.41  ?  341 GLU B CA  1 
ATOM   6033 C C   . GLU B 2 359 ? 138.647 125.834 113.156 1.00 52.41  ?  341 GLU B C   1 
ATOM   6034 O O   . GLU B 2 359 ? 139.285 124.784 113.047 1.00 52.41  ?  341 GLU B O   1 
ATOM   6035 C CB  . GLU B 2 359 ? 140.467 127.124 114.260 1.00 52.41  ?  341 GLU B CB  1 
ATOM   6036 C CG  . GLU B 2 359 ? 141.704 127.912 113.902 1.00 52.41  ?  341 GLU B CG  1 
ATOM   6037 C CD  . GLU B 2 359 ? 142.264 127.521 112.553 1.00 52.41  ?  341 GLU B CD  1 
ATOM   6038 O OE1 . GLU B 2 359 ? 142.250 128.365 111.634 1.00 52.41  ?  341 GLU B OE1 1 
ATOM   6039 O OE2 . GLU B 2 359 ? 142.708 126.364 112.406 1.00 52.41  -1 341 GLU B OE2 1 
ATOM   6040 N N   . GLY B 2 360 ? 137.318 125.840 113.269 1.00 50.37  ?  342 GLY B N   1 
ATOM   6041 C CA  . GLY B 2 360 ? 136.515 124.632 113.178 1.00 50.37  ?  342 GLY B CA  1 
ATOM   6042 C C   . GLY B 2 360 ? 135.806 124.269 114.467 1.00 50.37  ?  342 GLY B C   1 
ATOM   6043 O O   . GLY B 2 360 ? 134.780 123.585 114.433 1.00 50.37  ?  342 GLY B O   1 
ATOM   6044 N N   . HIS B 2 361 ? 136.339 124.704 115.602 1.00 52.28  ?  343 HIS B N   1 
ATOM   6045 C CA  . HIS B 2 361 ? 135.655 124.555 116.873 1.00 52.28  ?  343 HIS B CA  1 
ATOM   6046 C C   . HIS B 2 361 ? 134.610 125.662 116.980 1.00 52.28  ?  343 HIS B C   1 
ATOM   6047 O O   . HIS B 2 361 ? 134.535 126.530 116.108 1.00 52.28  ?  343 HIS B O   1 
ATOM   6048 C CB  . HIS B 2 361 ? 136.669 124.620 118.009 1.00 52.28  ?  343 HIS B CB  1 
ATOM   6049 C CG  . HIS B 2 361 ? 137.887 123.782 117.771 1.00 52.28  ?  343 HIS B CG  1 
ATOM   6050 N ND1 . HIS B 2 361 ? 139.049 124.298 117.243 1.00 52.28  ?  343 HIS B ND1 1 
ATOM   6051 C CD2 . HIS B 2 361 ? 138.112 122.459 117.942 1.00 52.28  ?  343 HIS B CD2 1 
ATOM   6052 C CE1 . HIS B 2 361 ? 139.946 123.337 117.126 1.00 52.28  ?  343 HIS B CE1 1 
ATOM   6053 N NE2 . HIS B 2 361 ? 139.401 122.209 117.539 1.00 52.28  ?  343 HIS B NE2 1 
ATOM   6054 N N   . LEU B 2 362 ? 133.781 125.633 118.052 1.00 53.77  ?  344 LEU B N   1 
ATOM   6055 C CA  . LEU B 2 362 ? 132.946 126.769 118.467 1.00 53.77  ?  344 LEU B CA  1 
ATOM   6056 C C   . LEU B 2 362 ? 132.032 127.351 117.395 1.00 53.77  ?  344 LEU B C   1 
ATOM   6057 O O   . LEU B 2 362 ? 132.411 128.371 116.816 1.00 53.77  ?  344 LEU B O   1 
ATOM   6058 C CB  . LEU B 2 362 ? 133.830 127.899 118.992 1.00 53.77  ?  344 LEU B CB  1 
ATOM   6059 C CG  . LEU B 2 362 ? 133.857 128.171 120.486 1.00 53.77  ?  344 LEU B CG  1 
ATOM   6060 C CD1 . LEU B 2 362 ? 134.305 126.946 121.244 1.00 53.77  ?  344 LEU B CD1 1 
ATOM   6061 C CD2 . LEU B 2 362 ? 134.790 129.333 120.728 1.00 53.77  ?  344 LEU B CD2 1 
ATOM   6062 N N   . PRO B 2 363 ? 130.829 126.753 117.129 1.00 56.26  ?  345 PRO B N   1 
ATOM   6063 C CA  . PRO B 2 363 ? 130.089 126.909 115.849 1.00 56.26  ?  345 PRO B CA  1 
ATOM   6064 C C   . PRO B 2 363 ? 130.053 128.266 115.153 1.00 56.26  ?  345 PRO B C   1 
ATOM   6065 O O   . PRO B 2 363 ? 129.932 129.304 115.807 1.00 56.26  ?  345 PRO B O   1 
ATOM   6066 C CB  . PRO B 2 363 ? 128.661 126.508 116.246 1.00 56.26  ?  345 PRO B CB  1 
ATOM   6067 C CG  . PRO B 2 363 ? 128.602 126.724 117.717 1.00 56.26  ?  345 PRO B CG  1 
ATOM   6068 C CD  . PRO B 2 363 ? 129.942 126.289 118.204 1.00 56.26  ?  345 PRO B CD  1 
ATOM   6069 N N   . ASP B 2 364 ? 130.110 128.258 113.819 1.00 56.49  ?  346 ASP B N   1 
ATOM   6070 C CA  . ASP B 2 364 ? 130.580 129.346 112.950 1.00 56.49  ?  346 ASP B CA  1 
ATOM   6071 C C   . ASP B 2 364 ? 129.739 130.630 113.004 1.00 56.49  ?  346 ASP B C   1 
ATOM   6072 O O   . ASP B 2 364 ? 130.054 131.522 112.209 1.00 56.49  ?  346 ASP B O   1 
ATOM   6073 C CB  . ASP B 2 364 ? 130.660 128.851 111.507 1.00 56.49  ?  346 ASP B CB  1 
ATOM   6074 C CG  . ASP B 2 364 ? 129.304 128.690 110.873 1.00 56.49  ?  346 ASP B CG  1 
ATOM   6075 O OD1 . ASP B 2 364 ? 128.389 128.179 111.550 1.00 56.49  ?  346 ASP B OD1 1 
ATOM   6076 O OD2 . ASP B 2 364 ? 129.148 129.080 109.699 1.00 56.49  -1 346 ASP B OD2 1 
ATOM   6077 N N   . ALA B 2 365 ? 128.718 130.781 113.847 1.00 52.19  ?  347 ALA B N   1 
ATOM   6078 C CA  . ALA B 2 365 ? 128.120 132.093 114.052 1.00 52.19  ?  347 ALA B CA  1 
ATOM   6079 C C   . ALA B 2 365 ? 129.082 133.048 114.745 1.00 52.19  ?  347 ALA B C   1 
ATOM   6080 O O   . ALA B 2 365 ? 129.000 134.260 114.539 1.00 52.19  ?  347 ALA B O   1 
ATOM   6081 C CB  . ALA B 2 365 ? 126.835 131.963 114.863 1.00 52.19  ?  347 ALA B CB  1 
ATOM   6082 N N   . ILE B 2 366 ? 130.011 132.528 115.551 1.00 49.54  ?  348 ILE B N   1 
ATOM   6083 C CA  . ILE B 2 366 ? 130.940 133.367 116.307 1.00 49.54  ?  348 ILE B CA  1 
ATOM   6084 C C   . ILE B 2 366 ? 132.063 133.920 115.437 1.00 49.54  ?  348 ILE B C   1 
ATOM   6085 O O   . ILE B 2 366 ? 132.821 134.790 115.881 1.00 49.54  ?  348 ILE B O   1 
ATOM   6086 C CB  . ILE B 2 366 ? 131.407 132.518 117.508 1.00 49.54  ?  348 ILE B CB  1 
ATOM   6087 C CG1 . ILE B 2 366 ? 130.212 131.761 118.092 1.00 49.54  ?  348 ILE B CG1 1 
ATOM   6088 C CG2 . ILE B 2 366 ? 132.029 133.357 118.612 1.00 49.54  ?  348 ILE B CG2 1 
ATOM   6089 C CD1 . ILE B 2 366 ? 130.507 130.976 119.347 1.00 49.54  ?  348 ILE B CD1 1 
ATOM   6090 N N   . CYS B 2 367 ? 132.156 133.487 114.186 1.00 51.62  ?  349 CYS B N   1 
ATOM   6091 C CA  . CYS B 2 367 ? 133.160 133.955 113.242 1.00 51.62  ?  349 CYS B CA  1 
ATOM   6092 C C   . CYS B 2 367 ? 132.647 135.105 112.370 1.00 51.62  ?  349 CYS B C   1 
ATOM   6093 O O   . CYS B 2 367 ? 133.420 135.690 111.608 1.00 51.62  ?  349 CYS B O   1 
ATOM   6094 C CB  . CYS B 2 367 ? 133.616 132.753 112.392 1.00 51.62  ?  349 CYS B CB  1 
ATOM   6095 S SG  . CYS B 2 367 ? 134.890 132.967 111.136 1.00 51.62  ?  349 CYS B SG  1 
ATOM   6096 N N   . MET B 2 368 ? 131.378 135.481 112.500 1.00 53.50  ?  350 MET B N   1 
ATOM   6097 C CA  . MET B 2 368 ? 130.775 136.466 111.613 1.00 53.50  ?  350 MET B CA  1 
ATOM   6098 C C   . MET B 2 368 ? 131.199 137.890 111.973 1.00 53.50  ?  350 MET B C   1 
ATOM   6099 O O   . MET B 2 368 ? 131.470 138.207 113.132 1.00 53.50  ?  350 MET B O   1 
ATOM   6100 C CB  . MET B 2 368 ? 129.253 136.348 111.658 1.00 53.50  ?  350 MET B CB  1 
ATOM   6101 C CG  . MET B 2 368 ? 128.721 134.956 111.371 1.00 53.50  ?  350 MET B CG  1 
ATOM   6102 S SD  . MET B 2 368 ? 128.265 134.661 109.665 1.00 53.50  ?  350 MET B SD  1 
ATOM   6103 C CE  . MET B 2 368 ? 127.570 133.019 109.788 1.00 53.50  ?  350 MET B CE  1 
ATOM   6104 N N   . ILE B 2 369 ? 131.257 138.749 110.951 1.00 52.43  ?  351 ILE B N   1 
ATOM   6105 C CA  . ILE B 2 369 ? 131.704 140.135 111.063 1.00 52.43  ?  351 ILE B CA  1 
ATOM   6106 C C   . ILE B 2 369 ? 130.598 141.044 110.541 1.00 52.43  ?  351 ILE B C   1 
ATOM   6107 O O   . ILE B 2 369 ? 129.978 140.741 109.517 1.00 52.43  ?  351 ILE B O   1 
ATOM   6108 C CB  . ILE B 2 369 ? 133.014 140.368 110.275 1.00 52.43  ?  351 ILE B CB  1 
ATOM   6109 C CG1 . ILE B 2 369 ? 134.075 139.337 110.659 1.00 52.43  ?  351 ILE B CG1 1 
ATOM   6110 C CG2 . ILE B 2 369 ? 133.564 141.762 110.496 1.00 52.43  ?  351 ILE B CG2 1 
ATOM   6111 C CD1 . ILE B 2 369 ? 135.266 139.322 109.745 1.00 52.43  ?  351 ILE B CD1 1 
ATOM   6112 N N   . HIS B 2 370 ? 130.358 142.156 111.243 1.00 52.81  ?  352 HIS B N   1 
ATOM   6113 C CA  . HIS B 2 370 ? 129.342 143.132 110.856 1.00 52.81  ?  352 HIS B CA  1 
ATOM   6114 C C   . HIS B 2 370 ? 129.670 143.769 109.506 1.00 52.81  ?  352 HIS B C   1 
ATOM   6115 O O   . HIS B 2 370 ? 130.833 144.036 109.197 1.00 52.81  ?  352 HIS B O   1 
ATOM   6116 C CB  . HIS B 2 370 ? 129.235 144.203 111.944 1.00 52.81  ?  352 HIS B CB  1 
ATOM   6117 C CG  . HIS B 2 370 ? 127.930 144.936 111.961 1.00 52.81  ?  352 HIS B CG  1 
ATOM   6118 N ND1 . HIS B 2 370 ? 127.660 145.995 111.123 1.00 52.81  ?  352 HIS B ND1 1 
ATOM   6119 C CD2 . HIS B 2 370 ? 126.830 144.778 112.730 1.00 52.81  ?  352 HIS B CD2 1 
ATOM   6120 C CE1 . HIS B 2 370 ? 126.445 146.449 111.364 1.00 52.81  ?  352 HIS B CE1 1 
ATOM   6121 N NE2 . HIS B 2 370 ? 125.918 145.726 112.334 1.00 52.81  ?  352 HIS B NE2 1 
ATOM   6122 N N   . VAL B 2 371 ? 128.631 144.021 108.700 1.00 54.69  ?  353 VAL B N   1 
ATOM   6123 C CA  . VAL B 2 371 ? 128.834 144.294 107.275 1.00 54.69  ?  353 VAL B CA  1 
ATOM   6124 C C   . VAL B 2 371 ? 129.371 145.707 107.044 1.00 54.69  ?  353 VAL B C   1 
ATOM   6125 O O   . VAL B 2 371 ? 130.209 145.923 106.163 1.00 54.69  ?  353 VAL B O   1 
ATOM   6126 C CB  . VAL B 2 371 ? 127.544 144.010 106.478 1.00 54.69  ?  353 VAL B CB  1 
ATOM   6127 C CG1 . VAL B 2 371 ? 127.268 142.528 106.478 1.00 54.69  ?  353 VAL B CG1 1 
ATOM   6128 C CG2 . VAL B 2 371 ? 126.348 144.726 107.067 1.00 54.69  ?  353 VAL B CG2 1 
ATOM   6129 N N   . GLU B 2 372 ? 128.893 146.685 107.799 1.00 57.55  ?  354 GLU B N   1 
ATOM   6130 C CA  . GLU B 2 372 ? 129.633 147.906 108.078 1.00 57.55  ?  354 GLU B CA  1 
ATOM   6131 C C   . GLU B 2 372 ? 130.025 147.850 109.542 1.00 57.55  ?  354 GLU B C   1 
ATOM   6132 O O   . GLU B 2 372 ? 129.608 146.929 110.241 1.00 57.55  ?  354 GLU B O   1 
ATOM   6133 C CB  . GLU B 2 372 ? 128.804 149.154 107.770 1.00 57.55  ?  354 GLU B CB  1 
ATOM   6134 C CG  . GLU B 2 372 ? 127.444 149.167 108.426 1.00 57.55  ?  354 GLU B CG  1 
ATOM   6135 C CD  . GLU B 2 372 ? 126.330 148.889 107.445 1.00 57.55  ?  354 GLU B CD  1 
ATOM   6136 O OE1 . GLU B 2 372 ? 126.634 148.545 106.285 1.00 57.55  ?  354 GLU B OE1 1 
ATOM   6137 O OE2 . GLU B 2 372 ? 125.150 149.015 107.830 1.00 57.55  -1 354 GLU B OE2 1 
ATOM   6138 N N   . ARG B 2 373 ? 130.805 148.841 109.993 1.00 55.75  ?  355 ARG B N   1 
ATOM   6139 C CA  . ARG B 2 373 ? 131.389 148.936 111.348 1.00 55.75  ?  355 ARG B CA  1 
ATOM   6140 C C   . ARG B 2 373 ? 132.010 147.600 111.786 1.00 55.75  ?  355 ARG B C   1 
ATOM   6141 O O   . ARG B 2 373 ? 131.532 146.909 112.683 1.00 55.75  ?  355 ARG B O   1 
ATOM   6142 C CB  . ARG B 2 373 ? 130.395 149.517 112.384 1.00 55.75  ?  355 ARG B CB  1 
ATOM   6143 C CG  . ARG B 2 373 ? 129.043 148.829 112.691 1.00 55.75  ?  355 ARG B CG  1 
ATOM   6144 C CD  . ARG B 2 373 ? 128.292 149.470 113.824 1.00 55.75  ?  355 ARG B CD  1 
ATOM   6145 N NE  . ARG B 2 373 ? 127.712 150.742 113.429 1.00 55.75  ?  355 ARG B NE  1 
ATOM   6146 C CZ  . ARG B 2 373 ? 127.140 151.586 114.275 1.00 55.75  ?  355 ARG B CZ  1 
ATOM   6147 N NH1 . ARG B 2 373 ? 127.080 151.283 115.560 1.00 55.75  1  355 ARG B NH1 1 
ATOM   6148 N NH2 . ARG B 2 373 ? 126.632 152.728 113.841 1.00 55.75  ?  355 ARG B NH2 1 
ATOM   6149 N N   . PHE B 2 374 ? 133.110 147.257 111.111 1.00 51.01  ?  356 PHE B N   1 
ATOM   6150 C CA  . PHE B 2 374 ? 133.592 145.876 110.985 1.00 51.01  ?  356 PHE B CA  1 
ATOM   6151 C C   . PHE B 2 374 ? 134.090 145.357 112.332 1.00 51.01  ?  356 PHE B C   1 
ATOM   6152 O O   . PHE B 2 374 ? 135.283 145.355 112.642 1.00 51.01  ?  356 PHE B O   1 
ATOM   6153 C CB  . PHE B 2 374 ? 134.703 145.799 109.945 1.00 51.01  ?  356 PHE B CB  1 
ATOM   6154 C CG  . PHE B 2 374 ? 134.348 146.407 108.623 1.00 51.01  ?  356 PHE B CG  1 
ATOM   6155 C CD1 . PHE B 2 374 ? 133.700 145.658 107.660 1.00 51.01  ?  356 PHE B CD1 1 
ATOM   6156 C CD2 . PHE B 2 374 ? 134.676 147.722 108.334 1.00 51.01  ?  356 PHE B CD2 1 
ATOM   6157 C CE1 . PHE B 2 374 ? 133.377 146.209 106.443 1.00 51.01  ?  356 PHE B CE1 1 
ATOM   6158 C CE2 . PHE B 2 374 ? 134.349 148.277 107.119 1.00 51.01  ?  356 PHE B CE2 1 
ATOM   6159 C CZ  . PHE B 2 374 ? 133.700 147.519 106.174 1.00 51.01  ?  356 PHE B CZ  1 
ATOM   6160 N N   . THR B 2 375 ? 133.138 144.890 113.140 1.00 46.49  ?  357 THR B N   1 
ATOM   6161 C CA  . THR B 2 375 ? 133.352 144.440 114.503 1.00 46.49  ?  357 THR B CA  1 
ATOM   6162 C C   . THR B 2 375 ? 132.791 143.035 114.678 1.00 46.49  ?  357 THR B C   1 
ATOM   6163 O O   . THR B 2 375 ? 131.762 142.701 114.083 1.00 46.49  ?  357 THR B O   1 
ATOM   6164 C CB  . THR B 2 375 ? 132.681 145.392 115.512 1.00 46.49  ?  357 THR B CB  1 
ATOM   6165 O OG1 . THR B 2 375 ? 131.301 145.558 115.177 1.00 46.49  ?  357 THR B OG1 1 
ATOM   6166 C CG2 . THR B 2 375 ? 133.352 146.744 115.505 1.00 46.49  ?  357 THR B CG2 1 
ATOM   6167 N N   . PRO B 2 376 ? 133.438 142.189 115.481 1.00 43.44  ?  358 PRO B N   1 
ATOM   6168 C CA  . PRO B 2 376 ? 132.913 140.825 115.707 1.00 43.44  ?  358 PRO B CA  1 
ATOM   6169 C C   . PRO B 2 376 ? 131.822 140.766 116.773 1.00 43.44  ?  358 PRO B C   1 
ATOM   6170 O O   . PRO B 2 376 ? 132.032 140.378 117.916 1.00 43.44  ?  358 PRO B O   1 
ATOM   6171 C CB  . PRO B 2 376 ? 134.166 140.056 116.128 1.00 43.44  ?  358 PRO B CB  1 
ATOM   6172 C CG  . PRO B 2 376 ? 135.020 141.075 116.784 1.00 43.44  ?  358 PRO B CG  1 
ATOM   6173 C CD  . PRO B 2 376 ? 134.752 142.387 116.118 1.00 43.44  ?  358 PRO B CD  1 
ATOM   6174 N N   . VAL B 2 377 ? 130.611 141.138 116.371 1.00 44.08  ?  359 VAL B N   1 
ATOM   6175 C CA  . VAL B 2 377 ? 129.487 141.365 117.284 1.00 44.08  ?  359 VAL B CA  1 
ATOM   6176 C C   . VAL B 2 377 ? 129.004 140.106 118.019 1.00 44.08  ?  359 VAL B C   1 
ATOM   6177 O O   . VAL B 2 377 ? 128.888 140.177 119.254 1.00 44.08  ?  359 VAL B O   1 
ATOM   6178 C CB  . VAL B 2 377 ? 128.338 142.084 116.544 1.00 44.08  ?  359 VAL B CB  1 
ATOM   6179 C CG1 . VAL B 2 377 ? 127.120 142.230 117.425 1.00 44.08  ?  359 VAL B CG1 1 
ATOM   6180 C CG2 . VAL B 2 377 ? 128.797 143.437 116.060 1.00 44.08  ?  359 VAL B CG2 1 
ATOM   6181 N N   . PRO B 2 378 ? 128.728 138.943 117.383 1.00 46.32  ?  360 PRO B N   1 
ATOM   6182 C CA  . PRO B 2 378 ? 128.243 137.801 118.188 1.00 46.32  ?  360 PRO B CA  1 
ATOM   6183 C C   . PRO B 2 378 ? 129.282 137.193 119.119 1.00 46.32  ?  360 PRO B C   1 
ATOM   6184 O O   . PRO B 2 378 ? 128.897 136.632 120.153 1.00 46.32  ?  360 PRO B O   1 
ATOM   6185 C CB  . PRO B 2 378 ? 127.784 136.789 117.132 1.00 46.32  ?  360 PRO B CB  1 
ATOM   6186 C CG  . PRO B 2 378 ? 128.499 137.138 115.945 1.00 46.32  ?  360 PRO B CG  1 
ATOM   6187 C CD  . PRO B 2 378 ? 128.660 138.596 115.946 1.00 46.32  ?  360 PRO B CD  1 
ATOM   6188 N N   . SER B 2 379 ? 130.574 137.332 118.821 1.00 43.61  ?  361 SER B N   1 
ATOM   6189 C CA  . SER B 2 379 ? 131.609 136.894 119.753 1.00 43.61  ?  361 SER B CA  1 
ATOM   6190 C C   . SER B 2 379 ? 131.600 137.736 121.024 1.00 43.61  ?  361 SER B C   1 
ATOM   6191 O O   . SER B 2 379 ? 131.666 137.200 122.140 1.00 43.61  ?  361 SER B O   1 
ATOM   6192 C CB  . SER B 2 379 ? 132.972 136.959 119.068 1.00 43.61  ?  361 SER B CB  1 
ATOM   6193 O OG  . SER B 2 379 ? 134.004 136.538 119.935 1.00 43.61  ?  361 SER B OG  1 
ATOM   6194 N N   . LEU B 2 380 ? 131.504 139.061 120.866 1.00 42.56  ?  362 LEU B N   1 
ATOM   6195 C CA  . LEU B 2 380 ? 131.409 139.966 122.007 1.00 42.56  ?  362 LEU B CA  1 
ATOM   6196 C C   . LEU B 2 380 ? 130.132 139.729 122.801 1.00 42.56  ?  362 LEU B C   1 
ATOM   6197 O O   . LEU B 2 380 ? 130.137 139.814 124.037 1.00 42.56  ?  362 LEU B O   1 
ATOM   6198 C CB  . LEU B 2 380 ? 131.473 141.414 121.526 1.00 42.56  ?  362 LEU B CB  1 
ATOM   6199 C CG  . LEU B 2 380 ? 132.813 141.953 121.033 1.00 42.56  ?  362 LEU B CG  1 
ATOM   6200 C CD1 . LEU B 2 380 ? 132.614 142.988 119.953 1.00 42.56  ?  362 LEU B CD1 1 
ATOM   6201 C CD2 . LEU B 2 380 ? 133.593 142.544 122.182 1.00 42.56  ?  362 LEU B CD2 1 
ATOM   6202 N N   . LEU B 2 381 ? 129.034 139.408 122.108 1.00 46.96  ?  363 LEU B N   1 
ATOM   6203 C CA  . LEU B 2 381 ? 127.777 139.113 122.792 1.00 46.96  ?  363 LEU B CA  1 
ATOM   6204 C C   . LEU B 2 381 ? 127.878 137.840 123.622 1.00 46.96  ?  363 LEU B C   1 
ATOM   6205 O O   . LEU B 2 381 ? 127.396 137.799 124.760 1.00 46.96  ?  363 LEU B O   1 
ATOM   6206 C CB  . LEU B 2 381 ? 126.643 138.988 121.778 1.00 46.96  ?  363 LEU B CB  1 
ATOM   6207 C CG  . LEU B 2 381 ? 126.132 140.265 121.121 1.00 46.96  ?  363 LEU B CG  1 
ATOM   6208 C CD1 . LEU B 2 381 ? 125.005 139.943 120.160 1.00 46.96  ?  363 LEU B CD1 1 
ATOM   6209 C CD2 . LEU B 2 381 ? 125.683 141.253 122.167 1.00 46.96  ?  363 LEU B CD2 1 
ATOM   6210 N N   . PHE B 2 382 ? 128.509 136.802 123.069 1.00 49.39  ?  364 PHE B N   1 
ATOM   6211 C CA  . PHE B 2 382 ? 128.696 135.549 123.794 1.00 49.39  ?  364 PHE B CA  1 
ATOM   6212 C C   . PHE B 2 382 ? 129.589 135.734 125.018 1.00 49.39  ?  364 PHE B C   1 
ATOM   6213 O O   . PHE B 2 382 ? 129.305 135.186 126.096 1.00 49.39  ?  364 PHE B O   1 
ATOM   6214 C CB  . PHE B 2 382 ? 129.283 134.508 122.845 1.00 49.39  ?  364 PHE B CB  1 
ATOM   6215 C CG  . PHE B 2 382 ? 129.523 133.183 123.476 1.00 49.39  ?  364 PHE B CG  1 
ATOM   6216 C CD1 . PHE B 2 382 ? 128.496 132.510 124.113 1.00 49.39  ?  364 PHE B CD1 1 
ATOM   6217 C CD2 . PHE B 2 382 ? 130.774 132.603 123.429 1.00 49.39  ?  364 PHE B CD2 1 
ATOM   6218 C CE1 . PHE B 2 382 ? 128.717 131.282 124.698 1.00 49.39  ?  364 PHE B CE1 1 
ATOM   6219 C CE2 . PHE B 2 382 ? 130.999 131.378 124.008 1.00 49.39  ?  364 PHE B CE2 1 
ATOM   6220 C CZ  . PHE B 2 382 ? 129.970 130.716 124.644 1.00 49.39  ?  364 PHE B CZ  1 
ATOM   6221 N N   . ASN B 2 383 ? 130.655 136.527 124.872 1.00 46.11  ?  365 ASN B N   1 
ATOM   6222 C CA  . ASN B 2 383 ? 131.551 136.814 125.989 1.00 46.11  ?  365 ASN B CA  1 
ATOM   6223 C C   . ASN B 2 383 ? 130.836 137.576 127.104 1.00 46.11  ?  365 ASN B C   1 
ATOM   6224 O O   . ASN B 2 383 ? 130.972 137.240 128.292 1.00 46.11  ?  365 ASN B O   1 
ATOM   6225 C CB  . ASN B 2 383 ? 132.752 137.604 125.476 1.00 46.11  ?  365 ASN B CB  1 
ATOM   6226 C CG  . ASN B 2 383 ? 133.738 137.929 126.561 1.00 46.11  ?  365 ASN B CG  1 
ATOM   6227 O OD1 . ASN B 2 383 ? 134.044 137.092 127.404 1.00 46.11  ?  365 ASN B OD1 1 
ATOM   6228 N ND2 . ASN B 2 383 ? 134.243 139.152 126.551 1.00 46.11  ?  365 ASN B ND2 1 
ATOM   6229 N N   . GLY B 2 384 ? 130.051 138.592 126.734 1.00 46.66  ?  366 GLY B N   1 
ATOM   6230 C CA  . GLY B 2 384 ? 129.307 139.344 127.730 1.00 46.66  ?  366 GLY B CA  1 
ATOM   6231 C C   . GLY B 2 384 ? 128.238 138.524 128.425 1.00 46.66  ?  366 GLY B C   1 
ATOM   6232 O O   . GLY B 2 384 ? 128.008 138.688 129.627 1.00 46.66  ?  366 GLY B O   1 
ATOM   6233 N N   . ILE B 2 385 ? 127.591 137.614 127.688 1.00 46.86  ?  367 ILE B N   1 
ATOM   6234 C CA  . ILE B 2 385 ? 126.577 136.742 128.279 1.00 46.86  ?  367 ILE B CA  1 
ATOM   6235 C C   . ILE B 2 385 ? 127.205 135.804 129.305 1.00 46.86  ?  367 ILE B C   1 
ATOM   6236 O O   . ILE B 2 385 ? 126.662 135.612 130.403 1.00 46.86  ?  367 ILE B O   1 
ATOM   6237 C CB  . ILE B 2 385 ? 125.832 135.974 127.168 1.00 46.86  ?  367 ILE B CB  1 
ATOM   6238 C CG1 . ILE B 2 385 ? 124.773 136.867 126.530 1.00 46.86  ?  367 ILE B CG1 1 
ATOM   6239 C CG2 . ILE B 2 385 ? 125.169 134.708 127.689 1.00 46.86  ?  367 ILE B CG2 1 
ATOM   6240 C CD1 . ILE B 2 385 ? 124.114 136.250 125.322 1.00 46.86  ?  367 ILE B CD1 1 
ATOM   6241 N N   . MET B 2 386 ? 128.380 135.245 128.987 1.00 49.41  ?  368 MET B N   1 
ATOM   6242 C CA  . MET B 2 386 ? 129.050 134.354 129.936 1.00 49.41  ?  368 MET B CA  1 
ATOM   6243 C C   . MET B 2 386 ? 129.516 135.099 131.186 1.00 49.41  ?  368 MET B C   1 
ATOM   6244 O O   . MET B 2 386 ? 129.406 134.573 132.304 1.00 49.41  ?  368 MET B O   1 
ATOM   6245 C CB  . MET B 2 386 ? 130.226 133.655 129.260 1.00 49.41  ?  368 MET B CB  1 
ATOM   6246 C CG  . MET B 2 386 ? 129.822 132.580 128.267 1.00 49.41  ?  368 MET B CG  1 
ATOM   6247 S SD  . MET B 2 386 ? 128.964 131.195 129.031 1.00 49.41  ?  368 MET B SD  1 
ATOM   6248 C CE  . MET B 2 386 ? 130.227 130.574 130.134 1.00 49.41  ?  368 MET B CE  1 
ATOM   6249 N N   . ALA B 2 387 ? 130.008 136.334 131.025 1.00 46.16  ?  369 ALA B N   1 
ATOM   6250 C CA  . ALA B 2 387 ? 130.424 137.113 132.192 1.00 46.16  ?  369 ALA B CA  1 
ATOM   6251 C C   . ALA B 2 387 ? 129.235 137.500 133.072 1.00 46.16  ?  369 ALA B C   1 
ATOM   6252 O O   . ALA B 2 387 ? 129.326 137.450 134.308 1.00 46.16  ?  369 ALA B O   1 
ATOM   6253 C CB  . ALA B 2 387 ? 131.189 138.356 131.746 1.00 46.16  ?  369 ALA B CB  1 
ATOM   6254 N N   . LEU B 2 388 ? 128.104 137.864 132.456 1.00 47.01  ?  370 LEU B N   1 
ATOM   6255 C CA  . LEU B 2 388 ? 126.906 138.174 133.232 1.00 47.01  ?  370 LEU B CA  1 
ATOM   6256 C C   . LEU B 2 388 ? 126.339 136.942 133.925 1.00 47.01  ?  370 LEU B C   1 
ATOM   6257 O O   . LEU B 2 388 ? 125.733 137.065 134.993 1.00 47.01  ?  370 LEU B O   1 
ATOM   6258 C CB  . LEU B 2 388 ? 125.840 138.801 132.340 1.00 47.01  ?  370 LEU B CB  1 
ATOM   6259 C CG  . LEU B 2 388 ? 126.092 140.222 131.848 1.00 47.01  ?  370 LEU B CG  1 
ATOM   6260 C CD1 . LEU B 2 388 ? 124.970 140.657 130.934 1.00 47.01  ?  370 LEU B CD1 1 
ATOM   6261 C CD2 . LEU B 2 388 ? 126.236 141.172 133.008 1.00 47.01  ?  370 LEU B CD2 1 
ATOM   6262 N N   . ILE B 2 389 ? 126.513 135.757 133.336 1.00 48.44  ?  371 ILE B N   1 
ATOM   6263 C CA  . ILE B 2 389 ? 126.092 134.532 134.009 1.00 48.44  ?  371 ILE B CA  1 
ATOM   6264 C C   . ILE B 2 389 ? 126.975 134.263 135.223 1.00 48.44  ?  371 ILE B C   1 
ATOM   6265 O O   . ILE B 2 389 ? 126.478 133.930 136.306 1.00 48.44  ?  371 ILE B O   1 
ATOM   6266 C CB  . ILE B 2 389 ? 126.092 133.354 133.016 1.00 48.44  ?  371 ILE B CB  1 
ATOM   6267 C CG1 . ILE B 2 389 ? 124.855 133.418 132.125 1.00 48.44  ?  371 ILE B CG1 1 
ATOM   6268 C CG2 . ILE B 2 389 ? 126.119 132.012 133.729 1.00 48.44  ?  371 ILE B CG2 1 
ATOM   6269 C CD1 . ILE B 2 389 ? 124.836 132.369 131.045 1.00 48.44  ?  371 ILE B CD1 1 
ATOM   6270 N N   . TYR B 2 390 ? 128.291 134.449 135.081 1.00 50.09  ?  372 TYR B N   1 
ATOM   6271 C CA  . TYR B 2 390 ? 129.186 134.207 136.210 1.00 50.09  ?  372 TYR B CA  1 
ATOM   6272 C C   . TYR B 2 390 ? 129.077 135.267 137.301 1.00 50.09  ?  372 TYR B C   1 
ATOM   6273 O O   . TYR B 2 390 ? 129.540 135.026 138.419 1.00 50.09  ?  372 TYR B O   1 
ATOM   6274 C CB  . TYR B 2 390 ? 130.631 134.108 135.734 1.00 50.09  ?  372 TYR B CB  1 
ATOM   6275 C CG  . TYR B 2 390 ? 131.060 132.694 135.441 1.00 50.09  ?  372 TYR B CG  1 
ATOM   6276 C CD1 . TYR B 2 390 ? 130.515 131.993 134.375 1.00 50.09  ?  372 TYR B CD1 1 
ATOM   6277 C CD2 . TYR B 2 390 ? 132.002 132.056 136.232 1.00 50.09  ?  372 TYR B CD2 1 
ATOM   6278 C CE1 . TYR B 2 390 ? 130.901 130.701 134.101 1.00 50.09  ?  372 TYR B CE1 1 
ATOM   6279 C CE2 . TYR B 2 390 ? 132.395 130.761 135.964 1.00 50.09  ?  372 TYR B CE2 1 
ATOM   6280 C CZ  . TYR B 2 390 ? 131.840 130.091 134.899 1.00 50.09  ?  372 TYR B CZ  1 
ATOM   6281 O OH  . TYR B 2 390 ? 132.226 128.802 134.628 1.00 50.09  ?  372 TYR B OH  1 
ATOM   6282 N N   . LEU B 2 391 ? 128.488 136.431 137.007 1.00 50.75  ?  373 LEU B N   1 
ATOM   6283 C CA  . LEU B 2 391 ? 128.191 137.391 138.072 1.00 50.75  ?  373 LEU B CA  1 
ATOM   6284 C C   . LEU B 2 391 ? 127.167 136.877 139.080 1.00 50.75  ?  373 LEU B C   1 
ATOM   6285 O O   . LEU B 2 391 ? 127.158 137.341 140.223 1.00 50.75  ?  373 LEU B O   1 
ATOM   6286 C CB  . LEU B 2 391 ? 127.671 138.708 137.499 1.00 50.75  ?  373 LEU B CB  1 
ATOM   6287 C CG  . LEU B 2 391 ? 128.667 139.754 137.020 1.00 50.75  ?  373 LEU B CG  1 
ATOM   6288 C CD1 . LEU B 2 391 ? 127.912 140.912 136.426 1.00 50.75  ?  373 LEU B CD1 1 
ATOM   6289 C CD2 . LEU B 2 391 ? 129.514 140.219 138.173 1.00 50.75  ?  373 LEU B CD2 1 
ATOM   6290 N N   . CYS B 2 392 ? 126.305 135.939 138.690 1.00 59.06  ?  374 CYS B N   1 
ATOM   6291 C CA  . CYS B 2 392 ? 125.224 135.491 139.559 1.00 59.06  ?  374 CYS B CA  1 
ATOM   6292 C C   . CYS B 2 392 ? 125.688 134.562 140.672 1.00 59.06  ?  374 CYS B C   1 
ATOM   6293 O O   . CYS B 2 392 ? 124.904 134.271 141.580 1.00 59.06  ?  374 CYS B O   1 
ATOM   6294 C CB  . CYS B 2 392 ? 124.150 134.783 138.733 1.00 59.06  ?  374 CYS B CB  1 
ATOM   6295 S SG  . CYS B 2 392 ? 122.990 135.888 137.910 1.00 59.06  ?  374 CYS B SG  1 
ATOM   6296 N N   . VAL B 2 393 ? 126.925 134.084 140.625 1.00 61.83  ?  375 VAL B N   1 
ATOM   6297 C CA  . VAL B 2 393 ? 127.421 133.148 141.627 1.00 61.83  ?  375 VAL B CA  1 
ATOM   6298 C C   . VAL B 2 393 ? 128.077 133.934 142.754 1.00 61.83  ?  375 VAL B C   1 
ATOM   6299 O O   . VAL B 2 393 ? 129.031 134.684 142.528 1.00 61.83  ?  375 VAL B O   1 
ATOM   6300 C CB  . VAL B 2 393 ? 128.404 132.146 141.008 1.00 61.83  ?  375 VAL B CB  1 
ATOM   6301 C CG1 . VAL B 2 393 ? 129.092 131.338 142.091 1.00 61.83  ?  375 VAL B CG1 1 
ATOM   6302 C CG2 . VAL B 2 393 ? 127.685 131.233 140.038 1.00 61.83  ?  375 VAL B CG2 1 
ATOM   6303 N N   . GLU B 2 394 ? 127.566 133.766 143.969 1.00 68.11  ?  376 GLU B N   1 
ATOM   6304 C CA  . GLU B 2 394 ? 128.176 134.386 145.133 1.00 68.11  ?  376 GLU B CA  1 
ATOM   6305 C C   . GLU B 2 394 ? 129.414 133.589 145.520 1.00 68.11  ?  376 GLU B C   1 
ATOM   6306 O O   . GLU B 2 394 ? 129.437 132.362 145.378 1.00 68.11  ?  376 GLU B O   1 
ATOM   6307 C CB  . GLU B 2 394 ? 127.168 134.446 146.285 1.00 68.11  ?  376 GLU B CB  1 
ATOM   6308 C CG  . GLU B 2 394 ? 127.683 135.042 147.590 1.00 68.11  ?  376 GLU B CG  1 
ATOM   6309 C CD  . GLU B 2 394 ? 126.875 134.612 148.792 1.00 68.11  ?  376 GLU B CD  1 
ATOM   6310 O OE1 . GLU B 2 394 ? 127.400 134.687 149.922 1.00 68.11  ?  376 GLU B OE1 1 
ATOM   6311 O OE2 . GLU B 2 394 ? 125.708 134.207 148.610 1.00 68.11  -1 376 GLU B OE2 1 
ATOM   6312 N N   . ASP B 2 395 ? 130.448 134.305 145.982 1.00 69.75  ?  377 ASP B N   1 
ATOM   6313 C CA  . ASP B 2 395 ? 131.777 133.777 146.308 1.00 69.75  ?  377 ASP B CA  1 
ATOM   6314 C C   . ASP B 2 395 ? 132.415 133.125 145.076 1.00 69.75  ?  377 ASP B C   1 
ATOM   6315 O O   . ASP B 2 395 ? 132.640 131.916 145.002 1.00 69.75  ?  377 ASP B O   1 
ATOM   6316 C CB  . ASP B 2 395 ? 131.728 132.817 147.511 1.00 69.75  ?  377 ASP B CB  1 
ATOM   6317 C CG  . ASP B 2 395 ? 133.108 132.407 147.998 1.00 69.75  ?  377 ASP B CG  1 
ATOM   6318 O OD1 . ASP B 2 395 ? 133.797 133.236 148.626 1.00 69.75  ?  377 ASP B OD1 1 
ATOM   6319 O OD2 . ASP B 2 395 ? 133.499 131.247 147.758 1.00 69.75  -1 377 ASP B OD2 1 
ATOM   6320 N N   . ILE B 2 396 ? 132.678 133.981 144.083 1.00 64.21  ?  378 ILE B N   1 
ATOM   6321 C CA  . ILE B 2 396 ? 133.458 133.564 142.922 1.00 64.21  ?  378 ILE B CA  1 
ATOM   6322 C C   . ILE B 2 396 ? 134.948 133.758 143.127 1.00 64.21  ?  378 ILE B C   1 
ATOM   6323 O O   . ILE B 2 396 ? 135.740 133.328 142.275 1.00 64.21  ?  378 ILE B O   1 
ATOM   6324 C CB  . ILE B 2 396 ? 133.051 134.306 141.634 1.00 64.21  ?  378 ILE B CB  1 
ATOM   6325 C CG1 . ILE B 2 396 ? 132.805 135.784 141.903 1.00 64.21  ?  378 ILE B CG1 1 
ATOM   6326 C CG2 . ILE B 2 396 ? 131.839 133.667 140.998 1.00 64.21  ?  378 ILE B CG2 1 
ATOM   6327 C CD1 . ILE B 2 396 ? 132.698 136.572 140.632 1.00 64.21  ?  378 ILE B CD1 1 
ATOM   6328 N N   . PHE B 2 397 ? 135.362 134.384 144.232 1.00 63.65  ?  379 PHE B N   1 
ATOM   6329 C CA  . PHE B 2 397 ? 136.781 134.521 144.533 1.00 63.65  ?  379 PHE B CA  1 
ATOM   6330 C C   . PHE B 2 397 ? 137.422 133.188 144.899 1.00 63.65  ?  379 PHE B C   1 
ATOM   6331 O O   . PHE B 2 397 ? 138.650 133.072 144.854 1.00 63.65  ?  379 PHE B O   1 
ATOM   6332 C CB  . PHE B 2 397 ? 136.973 135.539 145.656 1.00 63.65  ?  379 PHE B CB  1 
ATOM   6333 C CG  . PHE B 2 397 ? 136.514 136.924 145.298 1.00 63.65  ?  379 PHE B CG  1 
ATOM   6334 C CD1 . PHE B 2 397 ? 137.337 137.776 144.580 1.00 63.65  ?  379 PHE B CD1 1 
ATOM   6335 C CD2 . PHE B 2 397 ? 135.259 137.372 145.674 1.00 63.65  ?  379 PHE B CD2 1 
ATOM   6336 C CE1 . PHE B 2 397 ? 136.920 139.051 144.246 1.00 63.65  ?  379 PHE B CE1 1 
ATOM   6337 C CE2 . PHE B 2 397 ? 134.834 138.645 145.341 1.00 63.65  ?  379 PHE B CE2 1 
ATOM   6338 C CZ  . PHE B 2 397 ? 135.667 139.484 144.625 1.00 63.65  ?  379 PHE B CZ  1 
ATOM   6339 N N   . GLN B 2 398 ? 136.617 132.190 145.273 1.00 68.75  ?  380 GLN B N   1 
ATOM   6340 C CA  . GLN B 2 398 ? 137.096 130.815 145.359 1.00 68.75  ?  380 GLN B CA  1 
ATOM   6341 C C   . GLN B 2 398 ? 137.544 130.299 143.996 1.00 68.75  ?  380 GLN B C   1 
ATOM   6342 O O   . GLN B 2 398 ? 138.531 129.559 143.895 1.00 68.75  ?  380 GLN B O   1 
ATOM   6343 C CB  . GLN B 2 398 ? 135.988 129.929 145.933 1.00 68.75  ?  380 GLN B CB  1 
ATOM   6344 C CG  . GLN B 2 398 ? 136.332 128.455 146.094 1.00 68.75  ?  380 GLN B CG  1 
ATOM   6345 C CD  . GLN B 2 398 ? 137.404 128.204 147.133 1.00 68.75  ?  380 GLN B CD  1 
ATOM   6346 O OE1 . GLN B 2 398 ? 138.560 127.943 146.801 1.00 68.75  ?  380 GLN B OE1 1 
ATOM   6347 N NE2 . GLN B 2 398 ? 137.020 128.266 148.403 1.00 68.75  ?  380 GLN B NE2 1 
ATOM   6348 N N   . LEU B 2 399 ? 136.851 130.713 142.930 1.00 64.23  ?  381 LEU B N   1 
ATOM   6349 C CA  . LEU B 2 399 ? 137.015 130.117 141.608 1.00 64.23  ?  381 LEU B CA  1 
ATOM   6350 C C   . LEU B 2 399 ? 138.346 130.442 140.944 1.00 64.23  ?  381 LEU B C   1 
ATOM   6351 O O   . LEU B 2 399 ? 138.669 129.819 139.929 1.00 64.23  ?  381 LEU B O   1 
ATOM   6352 C CB  . LEU B 2 399 ? 135.877 130.559 140.690 1.00 64.23  ?  381 LEU B CB  1 
ATOM   6353 C CG  . LEU B 2 399 ? 134.457 130.148 141.073 1.00 64.23  ?  381 LEU B CG  1 
ATOM   6354 C CD1 . LEU B 2 399 ? 133.505 130.439 139.933 1.00 64.23  ?  381 LEU B CD1 1 
ATOM   6355 C CD2 . LEU B 2 399 ? 134.395 128.684 141.456 1.00 64.23  ?  381 LEU B CD2 1 
ATOM   6356 N N   . ILE B 2 400 ? 139.129 131.387 141.473 1.00 62.96  ?  382 ILE B N   1 
ATOM   6357 C CA  . ILE B 2 400 ? 140.475 131.587 140.943 1.00 62.96  ?  382 ILE B CA  1 
ATOM   6358 C C   . ILE B 2 400 ? 141.446 130.522 141.415 1.00 62.96  ?  382 ILE B C   1 
ATOM   6359 O O   . ILE B 2 400 ? 142.551 130.425 140.868 1.00 62.96  ?  382 ILE B O   1 
ATOM   6360 C CB  . ILE B 2 400 ? 141.069 132.959 141.308 1.00 62.96  ?  382 ILE B CB  1 
ATOM   6361 C CG1 . ILE B 2 400 ? 141.302 133.067 142.814 1.00 62.96  ?  382 ILE B CG1 1 
ATOM   6362 C CG2 . ILE B 2 400 ? 140.172 134.061 140.823 1.00 62.96  ?  382 ILE B CG2 1 
ATOM   6363 C CD1 . ILE B 2 400 ? 142.216 134.198 143.204 1.00 62.96  ?  382 ILE B CD1 1 
ATOM   6364 N N   . ASN B 2 401 ? 141.072 129.720 142.412 1.00 64.83  ?  383 ASN B N   1 
ATOM   6365 C CA  . ASN B 2 401 ? 141.920 128.620 142.846 1.00 64.83  ?  383 ASN B CA  1 
ATOM   6366 C C   . ASN B 2 401 ? 141.844 127.420 141.918 1.00 64.83  ?  383 ASN B C   1 
ATOM   6367 O O   . ASN B 2 401 ? 142.622 126.477 142.088 1.00 64.83  ?  383 ASN B O   1 
ATOM   6368 C CB  . ASN B 2 401 ? 141.541 128.191 144.262 1.00 64.83  ?  383 ASN B CB  1 
ATOM   6369 C CG  . ASN B 2 401 ? 141.674 129.314 145.262 1.00 64.83  ?  383 ASN B CG  1 
ATOM   6370 O OD1 . ASN B 2 401 ? 140.713 129.676 145.935 1.00 64.83  ?  383 ASN B OD1 1 
ATOM   6371 N ND2 . ASN B 2 401 ? 142.870 129.875 145.365 1.00 64.83  ?  383 ASN B ND2 1 
ATOM   6372 N N   . TYR B 2 402 ? 140.940 127.433 140.942 1.00 63.17  ?  384 TYR B N   1 
ATOM   6373 C CA  . TYR B 2 402 ? 140.761 126.305 140.046 1.00 63.17  ?  384 TYR B CA  1 
ATOM   6374 C C   . TYR B 2 402 ? 141.513 126.449 138.732 1.00 63.17  ?  384 TYR B C   1 
ATOM   6375 O O   . TYR B 2 402 ? 141.721 125.443 138.049 1.00 63.17  ?  384 TYR B O   1 
ATOM   6376 C CB  . TYR B 2 402 ? 139.273 126.091 139.757 1.00 63.17  ?  384 TYR B CB  1 
ATOM   6377 C CG  . TYR B 2 402 ? 138.463 125.712 140.974 1.00 63.17  ?  384 TYR B CG  1 
ATOM   6378 C CD1 . TYR B 2 402 ? 139.037 125.005 142.022 1.00 63.17  ?  384 TYR B CD1 1 
ATOM   6379 C CD2 . TYR B 2 402 ? 137.124 126.057 141.072 1.00 63.17  ?  384 TYR B CD2 1 
ATOM   6380 C CE1 . TYR B 2 402 ? 138.300 124.658 143.135 1.00 63.17  ?  384 TYR B CE1 1 
ATOM   6381 C CE2 . TYR B 2 402 ? 136.380 125.711 142.180 1.00 63.17  ?  384 TYR B CE2 1 
ATOM   6382 C CZ  . TYR B 2 402 ? 136.974 125.013 143.207 1.00 63.17  ?  384 TYR B CZ  1 
ATOM   6383 O OH  . TYR B 2 402 ? 136.234 124.670 144.311 1.00 63.17  ?  384 TYR B OH  1 
ATOM   6384 N N   . TYR B 2 403 ? 141.932 127.655 138.354 1.00 58.21  ?  385 TYR B N   1 
ATOM   6385 C CA  . TYR B 2 403 ? 142.764 127.819 137.169 1.00 58.21  ?  385 TYR B CA  1 
ATOM   6386 C C   . TYR B 2 403 ? 144.111 128.443 137.510 1.00 58.21  ?  385 TYR B C   1 
ATOM   6387 O O   . TYR B 2 403 ? 144.745 129.070 136.662 1.00 58.21  ?  385 TYR B O   1 
ATOM   6388 C CB  . TYR B 2 403 ? 142.044 128.620 136.082 1.00 58.21  ?  385 TYR B CB  1 
ATOM   6389 C CG  . TYR B 2 403 ? 141.564 130.005 136.454 1.00 58.21  ?  385 TYR B CG  1 
ATOM   6390 C CD1 . TYR B 2 403 ? 142.371 131.120 136.256 1.00 58.21  ?  385 TYR B CD1 1 
ATOM   6391 C CD2 . TYR B 2 403 ? 140.284 130.204 136.953 1.00 58.21  ?  385 TYR B CD2 1 
ATOM   6392 C CE1 . TYR B 2 403 ? 141.933 132.382 136.577 1.00 58.21  ?  385 TYR B CE1 1 
ATOM   6393 C CE2 . TYR B 2 403 ? 139.834 131.467 137.270 1.00 58.21  ?  385 TYR B CE2 1 
ATOM   6394 C CZ  . TYR B 2 403 ? 140.664 132.550 137.080 1.00 58.21  ?  385 TYR B CZ  1 
ATOM   6395 O OH  . TYR B 2 403 ? 140.222 133.810 137.397 1.00 58.21  ?  385 TYR B OH  1 
ATOM   6396 N N   . SER B 2 404 ? 144.566 128.265 138.751 1.00 59.74  ?  386 SER B N   1 
ATOM   6397 C CA  . SER B 2 404 ? 145.932 128.645 139.094 1.00 59.74  ?  386 SER B CA  1 
ATOM   6398 C C   . SER B 2 404 ? 146.945 127.752 138.395 1.00 59.74  ?  386 SER B C   1 
ATOM   6399 O O   . SER B 2 404 ? 148.037 128.208 138.044 1.00 59.74  ?  386 SER B O   1 
ATOM   6400 C CB  . SER B 2 404 ? 146.136 128.580 140.606 1.00 59.74  ?  386 SER B CB  1 
ATOM   6401 O OG  . SER B 2 404 ? 145.655 129.749 141.237 1.00 59.74  ?  386 SER B OG  1 
ATOM   6402 N N   . PHE B 2 405 ? 146.594 126.486 138.180 1.00 58.50  ?  387 PHE B N   1 
ATOM   6403 C CA  . PHE B 2 405 ? 147.501 125.542 137.547 1.00 58.50  ?  387 PHE B CA  1 
ATOM   6404 C C   . PHE B 2 405 ? 147.441 125.636 136.028 1.00 58.50  ?  387 PHE B C   1 
ATOM   6405 O O   . PHE B 2 405 ? 148.466 125.490 135.358 1.00 58.50  ?  387 PHE B O   1 
ATOM   6406 C CB  . PHE B 2 405 ? 147.167 124.124 138.018 1.00 58.50  ?  387 PHE B CB  1 
ATOM   6407 C CG  . PHE B 2 405 ? 147.855 123.039 137.241 1.00 58.50  ?  387 PHE B CG  1 
ATOM   6408 C CD1 . PHE B 2 405 ? 149.188 122.757 137.463 1.00 58.50  ?  387 PHE B CD1 1 
ATOM   6409 C CD2 . PHE B 2 405 ? 147.162 122.287 136.304 1.00 58.50  ?  387 PHE B CD2 1 
ATOM   6410 C CE1 . PHE B 2 405 ? 149.824 121.758 136.755 1.00 58.50  ?  387 PHE B CE1 1 
ATOM   6411 C CE2 . PHE B 2 405 ? 147.795 121.293 135.591 1.00 58.50  ?  387 PHE B CE2 1 
ATOM   6412 C CZ  . PHE B 2 405 ? 149.125 121.025 135.820 1.00 58.50  ?  387 PHE B CZ  1 
ATOM   6413 N N   . SER B 2 406 ? 146.256 125.898 135.471 1.00 57.78  ?  388 SER B N   1 
ATOM   6414 C CA  . SER B 2 406 ? 146.033 125.719 134.040 1.00 57.78  ?  388 SER B CA  1 
ATOM   6415 C C   . SER B 2 406 ? 146.645 126.839 133.207 1.00 57.78  ?  388 SER B C   1 
ATOM   6416 O O   . SER B 2 406 ? 147.148 126.585 132.104 1.00 57.78  ?  388 SER B O   1 
ATOM   6417 C CB  . SER B 2 406 ? 144.535 125.620 133.762 1.00 57.78  ?  388 SER B CB  1 
ATOM   6418 O OG  . SER B 2 406 ? 143.996 124.428 134.298 1.00 57.78  ?  388 SER B OG  1 
ATOM   6419 N N   . TYR B 2 407 ? 146.603 128.072 133.722 1.00 57.29  ?  389 TYR B N   1 
ATOM   6420 C CA  . TYR B 2 407 ? 147.031 129.248 132.966 1.00 57.29  ?  389 TYR B CA  1 
ATOM   6421 C C   . TYR B 2 407 ? 148.522 129.193 132.651 1.00 57.29  ?  389 TYR B C   1 
ATOM   6422 O O   . TYR B 2 407 ? 148.936 129.313 131.487 1.00 57.29  ?  389 TYR B O   1 
ATOM   6423 C CB  . TYR B 2 407 ? 146.673 130.503 133.767 1.00 57.29  ?  389 TYR B CB  1 
ATOM   6424 C CG  . TYR B 2 407 ? 147.209 131.809 133.232 1.00 57.29  ?  389 TYR B CG  1 
ATOM   6425 C CD1 . TYR B 2 407 ? 146.605 132.440 132.154 1.00 57.29  ?  389 TYR B CD1 1 
ATOM   6426 C CD2 . TYR B 2 407 ? 148.303 132.425 133.825 1.00 57.29  ?  389 TYR B CD2 1 
ATOM   6427 C CE1 . TYR B 2 407 ? 147.088 133.638 131.668 1.00 57.29  ?  389 TYR B CE1 1 
ATOM   6428 C CE2 . TYR B 2 407 ? 148.793 133.620 133.347 1.00 57.29  ?  389 TYR B CE2 1 
ATOM   6429 C CZ  . TYR B 2 407 ? 148.181 134.223 132.269 1.00 57.29  ?  389 TYR B CZ  1 
ATOM   6430 O OH  . TYR B 2 407 ? 148.667 135.416 131.788 1.00 57.29  ?  389 TYR B OH  1 
ATOM   6431 N N   . TRP B 2 408 ? 149.340 128.947 133.674 1.00 55.09  ?  390 TRP B N   1 
ATOM   6432 C CA  . TRP B 2 408 ? 150.775 128.840 133.454 1.00 55.09  ?  390 TRP B CA  1 
ATOM   6433 C C   . TRP B 2 408 ? 151.140 127.551 132.737 1.00 55.09  ?  390 TRP B C   1 
ATOM   6434 O O   . TRP B 2 408 ? 152.166 127.504 132.050 1.00 55.09  ?  390 TRP B O   1 
ATOM   6435 C CB  . TRP B 2 408 ? 151.514 128.951 134.783 1.00 55.09  ?  390 TRP B CB  1 
ATOM   6436 C CG  . TRP B 2 408 ? 151.432 130.319 135.362 1.00 55.09  ?  390 TRP B CG  1 
ATOM   6437 C CD1 . TRP B 2 408 ? 150.784 130.682 136.499 1.00 55.09  ?  390 TRP B CD1 1 
ATOM   6438 C CD2 . TRP B 2 408 ? 152.005 131.518 134.825 1.00 55.09  ?  390 TRP B CD2 1 
ATOM   6439 N NE1 . TRP B 2 408 ? 150.921 132.028 136.711 1.00 55.09  ?  390 TRP B NE1 1 
ATOM   6440 C CE2 . TRP B 2 408 ? 151.667 132.565 135.698 1.00 55.09  ?  390 TRP B CE2 1 
ATOM   6441 C CE3 . TRP B 2 408 ? 152.775 131.805 133.694 1.00 55.09  ?  390 TRP B CE3 1 
ATOM   6442 C CZ2 . TRP B 2 408 ? 152.069 133.876 135.479 1.00 55.09  ?  390 TRP B CZ2 1 
ATOM   6443 C CZ3 . TRP B 2 408 ? 153.172 133.107 133.478 1.00 55.09  ?  390 TRP B CZ3 1 
ATOM   6444 C CH2 . TRP B 2 408 ? 152.818 134.126 134.364 1.00 55.09  ?  390 TRP B CH2 1 
ATOM   6445 N N   . PHE B 2 409 ? 150.303 126.516 132.859 1.00 52.11  ?  391 PHE B N   1 
ATOM   6446 C CA  . PHE B 2 409 ? 150.509 125.293 132.092 1.00 52.11  ?  391 PHE B CA  1 
ATOM   6447 C C   . PHE B 2 409 ? 150.391 125.556 130.599 1.00 52.11  ?  391 PHE B C   1 
ATOM   6448 O O   . PHE B 2 409 ? 151.212 125.074 129.813 1.00 52.11  ?  391 PHE B O   1 
ATOM   6449 C CB  . PHE B 2 409 ? 149.509 124.222 132.525 1.00 52.11  ?  391 PHE B CB  1 
ATOM   6450 C CG  . PHE B 2 409 ? 149.622 122.942 131.753 1.00 52.11  ?  391 PHE B CG  1 
ATOM   6451 C CD1 . PHE B 2 409 ? 150.649 122.052 132.017 1.00 52.11  ?  391 PHE B CD1 1 
ATOM   6452 C CD2 . PHE B 2 409 ? 148.701 122.626 130.767 1.00 52.11  ?  391 PHE B CD2 1 
ATOM   6453 C CE1 . PHE B 2 409 ? 150.761 120.874 131.309 1.00 52.11  ?  391 PHE B CE1 1 
ATOM   6454 C CE2 . PHE B 2 409 ? 148.810 121.452 130.053 1.00 52.11  ?  391 PHE B CE2 1 
ATOM   6455 C CZ  . PHE B 2 409 ? 149.840 120.575 130.326 1.00 52.11  ?  391 PHE B CZ  1 
ATOM   6456 N N   . PHE B 2 410 ? 149.402 126.350 130.190 1.00 50.73  ?  392 PHE B N   1 
ATOM   6457 C CA  . PHE B 2 410 ? 149.263 126.625 128.765 1.00 50.73  ?  392 PHE B CA  1 
ATOM   6458 C C   . PHE B 2 410 ? 150.280 127.643 128.264 1.00 50.73  ?  392 PHE B C   1 
ATOM   6459 O O   . PHE B 2 410 ? 150.702 127.558 127.101 1.00 50.73  ?  392 PHE B O   1 
ATOM   6460 C CB  . PHE B 2 410 ? 147.838 127.067 128.457 1.00 50.73  ?  392 PHE B CB  1 
ATOM   6461 C CG  . PHE B 2 410 ? 146.863 125.939 128.494 1.00 50.73  ?  392 PHE B CG  1 
ATOM   6462 C CD1 . PHE B 2 410 ? 147.088 124.801 127.739 1.00 50.73  ?  392 PHE B CD1 1 
ATOM   6463 C CD2 . PHE B 2 410 ? 145.749 125.990 129.308 1.00 50.73  ?  392 PHE B CD2 1 
ATOM   6464 C CE1 . PHE B 2 410 ? 146.207 123.744 127.778 1.00 50.73  ?  392 PHE B CE1 1 
ATOM   6465 C CE2 . PHE B 2 410 ? 144.872 124.934 129.354 1.00 50.73  ?  392 PHE B CE2 1 
ATOM   6466 C CZ  . PHE B 2 410 ? 145.096 123.813 128.588 1.00 50.73  ?  392 PHE B CZ  1 
ATOM   6467 N N   . VAL B 2 411 ? 150.721 128.570 129.123 1.00 50.87  ?  393 VAL B N   1 
ATOM   6468 C CA  . VAL B 2 411 ? 151.823 129.459 128.741 1.00 50.87  ?  393 VAL B CA  1 
ATOM   6469 C C   . VAL B 2 411 ? 153.106 128.656 128.508 1.00 50.87  ?  393 VAL B C   1 
ATOM   6470 O O   . VAL B 2 411 ? 153.789 128.819 127.484 1.00 50.87  ?  393 VAL B O   1 
ATOM   6471 C CB  . VAL B 2 411 ? 152.022 130.560 129.799 1.00 50.87  ?  393 VAL B CB  1 
ATOM   6472 C CG1 . VAL B 2 411 ? 153.255 131.384 129.488 1.00 50.87  ?  393 VAL B CG1 1 
ATOM   6473 C CG2 . VAL B 2 411 ? 150.811 131.463 129.853 1.00 50.87  ?  393 VAL B CG2 1 
ATOM   6474 N N   . GLY B 2 412 ? 153.421 127.738 129.427 1.00 50.69  ?  394 GLY B N   1 
ATOM   6475 C CA  . GLY B 2 412 ? 154.587 126.889 129.254 1.00 50.69  ?  394 GLY B CA  1 
ATOM   6476 C C   . GLY B 2 412 ? 154.467 125.917 128.098 1.00 50.69  ?  394 GLY B C   1 
ATOM   6477 O O   . GLY B 2 412 ? 155.470 125.581 127.461 1.00 50.69  ?  394 GLY B O   1 
ATOM   6478 N N   . LEU B 2 413 ? 153.245 125.469 127.798 1.00 49.01  ?  395 LEU B N   1 
ATOM   6479 C CA  . LEU B 2 413 ? 153.028 124.614 126.638 1.00 49.01  ?  395 LEU B CA  1 
ATOM   6480 C C   . LEU B 2 413 ? 153.276 125.369 125.340 1.00 49.01  ?  395 LEU B C   1 
ATOM   6481 O O   . LEU B 2 413 ? 153.834 124.809 124.391 1.00 49.01  ?  395 LEU B O   1 
ATOM   6482 C CB  . LEU B 2 413 ? 151.612 124.049 126.669 1.00 49.01  ?  395 LEU B CB  1 
ATOM   6483 C CG  . LEU B 2 413 ? 151.319 122.873 125.745 1.00 49.01  ?  395 LEU B CG  1 
ATOM   6484 C CD1 . LEU B 2 413 ? 152.203 121.696 126.093 1.00 49.01  ?  395 LEU B CD1 1 
ATOM   6485 C CD2 . LEU B 2 413 ? 149.858 122.496 125.842 1.00 49.01  ?  395 LEU B CD2 1 
ATOM   6486 N N   . SER B 2 414 ? 152.904 126.650 125.289 1.00 49.46  ?  396 SER B N   1 
ATOM   6487 C CA  . SER B 2 414 ? 153.233 127.448 124.112 1.00 49.46  ?  396 SER B CA  1 
ATOM   6488 C C   . SER B 2 414 ? 154.735 127.700 123.995 1.00 49.46  ?  396 SER B C   1 
ATOM   6489 O O   . SER B 2 414 ? 155.265 127.755 122.879 1.00 49.46  ?  396 SER B O   1 
ATOM   6490 C CB  . SER B 2 414 ? 152.469 128.766 124.141 1.00 49.46  ?  396 SER B CB  1 
ATOM   6491 O OG  . SER B 2 414 ? 152.880 129.560 125.235 1.00 49.46  ?  396 SER B OG  1 
ATOM   6492 N N   . ILE B 2 415 ? 155.440 127.819 125.125 1.00 50.90  ?  397 ILE B N   1 
ATOM   6493 C CA  . ILE B 2 415 ? 156.894 128.004 125.062 1.00 50.90  ?  397 ILE B CA  1 
ATOM   6494 C C   . ILE B 2 415 ? 157.593 126.733 124.564 1.00 50.90  ?  397 ILE B C   1 
ATOM   6495 O O   . ILE B 2 415 ? 158.506 126.798 123.723 1.00 50.90  ?  397 ILE B O   1 
ATOM   6496 C CB  . ILE B 2 415 ? 157.441 128.463 126.427 1.00 50.90  ?  397 ILE B CB  1 
ATOM   6497 C CG1 . ILE B 2 415 ? 156.810 129.790 126.844 1.00 50.90  ?  397 ILE B CG1 1 
ATOM   6498 C CG2 . ILE B 2 415 ? 158.942 128.642 126.378 1.00 50.90  ?  397 ILE B CG2 1 
ATOM   6499 C CD1 . ILE B 2 415 ? 156.901 130.878 125.809 1.00 50.90  ?  397 ILE B CD1 1 
ATOM   6500 N N   . VAL B 2 416 ? 157.168 125.557 125.042 1.00 51.03  ?  398 VAL B N   1 
ATOM   6501 C CA  . VAL B 2 416 ? 157.771 124.331 124.519 1.00 51.03  ?  398 VAL B CA  1 
ATOM   6502 C C   . VAL B 2 416 ? 157.323 124.054 123.088 1.00 51.03  ?  398 VAL B C   1 
ATOM   6503 O O   . VAL B 2 416 ? 158.051 123.394 122.340 1.00 51.03  ?  398 VAL B O   1 
ATOM   6504 C CB  . VAL B 2 416 ? 157.513 123.098 125.415 1.00 51.03  ?  398 VAL B CB  1 
ATOM   6505 C CG1 . VAL B 2 416 ? 157.849 123.399 126.842 1.00 51.03  ?  398 VAL B CG1 1 
ATOM   6506 C CG2 . VAL B 2 416 ? 156.092 122.589 125.306 1.00 51.03  ?  398 VAL B CG2 1 
ATOM   6507 N N   . GLY B 2 417 ? 156.174 124.588 122.664 1.00 51.82  ?  399 GLY B N   1 
ATOM   6508 C CA  . GLY B 2 417 ? 155.818 124.515 121.259 1.00 51.82  ?  399 GLY B CA  1 
ATOM   6509 C C   . GLY B 2 417 ? 156.709 125.381 120.394 1.00 51.82  ?  399 GLY B C   1 
ATOM   6510 O O   . GLY B 2 417 ? 157.049 125.005 119.270 1.00 51.82  ?  399 GLY B O   1 
ATOM   6511 N N   . GLN B 2 418 ? 157.105 126.545 120.914 1.00 53.23  ?  400 GLN B N   1 
ATOM   6512 C CA  . GLN B 2 418 ? 158.080 127.386 120.224 1.00 53.23  ?  400 GLN B CA  1 
ATOM   6513 C C   . GLN B 2 418 ? 159.426 126.685 120.095 1.00 53.23  ?  400 GLN B C   1 
ATOM   6514 O O   . GLN B 2 418 ? 160.068 126.745 119.039 1.00 53.23  ?  400 GLN B O   1 
ATOM   6515 C CB  . GLN B 2 418 ? 158.237 128.710 120.966 1.00 53.23  ?  400 GLN B CB  1 
ATOM   6516 C CG  . GLN B 2 418 ? 159.314 129.617 120.414 1.00 53.23  ?  400 GLN B CG  1 
ATOM   6517 C CD  . GLN B 2 418 ? 159.721 130.685 121.397 1.00 53.23  ?  400 GLN B CD  1 
ATOM   6518 O OE1 . GLN B 2 418 ? 159.534 130.537 122.601 1.00 53.23  ?  400 GLN B OE1 1 
ATOM   6519 N NE2 . GLN B 2 418 ? 160.278 131.770 120.892 1.00 53.23  ?  400 GLN B NE2 1 
ATOM   6520 N N   . LEU B 2 419 ? 159.854 125.990 121.154 1.00 53.59  ?  401 LEU B N   1 
ATOM   6521 C CA  . LEU B 2 419 ? 161.106 125.231 121.094 1.00 53.59  ?  401 LEU B CA  1 
ATOM   6522 C C   . LEU B 2 419 ? 161.028 124.083 120.090 1.00 53.59  ?  401 LEU B C   1 
ATOM   6523 O O   . LEU B 2 419 ? 161.963 123.869 119.303 1.00 53.59  ?  401 LEU B O   1 
ATOM   6524 C CB  . LEU B 2 419 ? 161.461 124.694 122.477 1.00 53.59  ?  401 LEU B CB  1 
ATOM   6525 C CG  . LEU B 2 419 ? 162.129 125.672 123.437 1.00 53.59  ?  401 LEU B CG  1 
ATOM   6526 C CD1 . LEU B 2 419 ? 162.266 125.044 124.808 1.00 53.59  ?  401 LEU B CD1 1 
ATOM   6527 C CD2 . LEU B 2 419 ? 163.477 126.092 122.897 1.00 53.59  ?  401 LEU B CD2 1 
ATOM   6528 N N   . TYR B 2 420 ? 159.914 123.344 120.099 1.00 55.73  ?  402 TYR B N   1 
ATOM   6529 C CA  . TYR B 2 420 ? 159.729 122.235 119.171 1.00 55.73  ?  402 TYR B CA  1 
ATOM   6530 C C   . TYR B 2 420 ? 159.638 122.708 117.726 1.00 55.73  ?  402 TYR B C   1 
ATOM   6531 O O   . TYR B 2 420 ? 160.108 122.012 116.821 1.00 55.73  ?  402 TYR B O   1 
ATOM   6532 C CB  . TYR B 2 420 ? 158.478 121.450 119.559 1.00 55.73  ?  402 TYR B CB  1 
ATOM   6533 C CG  . TYR B 2 420 ? 158.115 120.335 118.613 1.00 55.73  ?  402 TYR B CG  1 
ATOM   6534 C CD1 . TYR B 2 420 ? 158.862 119.168 118.567 1.00 55.73  ?  402 TYR B CD1 1 
ATOM   6535 C CD2 . TYR B 2 420 ? 157.014 120.442 117.776 1.00 55.73  ?  402 TYR B CD2 1 
ATOM   6536 C CE1 . TYR B 2 420 ? 158.530 118.145 117.708 1.00 55.73  ?  402 TYR B CE1 1 
ATOM   6537 C CE2 . TYR B 2 420 ? 156.674 119.424 116.913 1.00 55.73  ?  402 TYR B CE2 1 
ATOM   6538 C CZ  . TYR B 2 420 ? 157.436 118.279 116.885 1.00 55.73  ?  402 TYR B CZ  1 
ATOM   6539 O OH  . TYR B 2 420 ? 157.100 117.261 116.027 1.00 55.73  ?  402 TYR B OH  1 
ATOM   6540 N N   . LEU B 2 421 ? 159.055 123.884 117.486 1.00 56.85  ?  403 LEU B N   1 
ATOM   6541 C CA  . LEU B 2 421 ? 159.043 124.423 116.131 1.00 56.85  ?  403 LEU B CA  1 
ATOM   6542 C C   . LEU B 2 421 ? 160.402 124.979 115.732 1.00 56.85  ?  403 LEU B C   1 
ATOM   6543 O O   . LEU B 2 421 ? 160.716 125.037 114.540 1.00 56.85  ?  403 LEU B O   1 
ATOM   6544 C CB  . LEU B 2 421 ? 157.972 125.503 115.997 1.00 56.85  ?  403 LEU B CB  1 
ATOM   6545 C CG  . LEU B 2 421 ? 156.582 125.036 115.572 1.00 56.85  ?  403 LEU B CG  1 
ATOM   6546 C CD1 . LEU B 2 421 ? 155.701 126.231 115.299 1.00 56.85  ?  403 LEU B CD1 1 
ATOM   6547 C CD2 . LEU B 2 421 ? 156.663 124.143 114.353 1.00 56.85  ?  403 LEU B CD2 1 
ATOM   6548 N N   . ARG B 2 422 ? 161.214 125.405 116.703 1.00 58.79  ?  404 ARG B N   1 
ATOM   6549 C CA  . ARG B 2 422 ? 162.586 125.783 116.387 1.00 58.79  ?  404 ARG B CA  1 
ATOM   6550 C C   . ARG B 2 422 ? 163.420 124.574 115.997 1.00 58.79  ?  404 ARG B C   1 
ATOM   6551 O O   . ARG B 2 422 ? 164.327 124.692 115.168 1.00 58.79  ?  404 ARG B O   1 
ATOM   6552 C CB  . ARG B 2 422 ? 163.232 126.500 117.569 1.00 58.79  ?  404 ARG B CB  1 
ATOM   6553 C CG  . ARG B 2 422 ? 162.887 127.967 117.665 1.00 58.79  ?  404 ARG B CG  1 
ATOM   6554 C CD  . ARG B 2 422 ? 163.628 128.773 116.622 1.00 58.79  ?  404 ARG B CD  1 
ATOM   6555 N NE  . ARG B 2 422 ? 164.968 129.137 117.060 1.00 58.79  ?  404 ARG B NE  1 
ATOM   6556 C CZ  . ARG B 2 422 ? 165.246 130.206 117.796 1.00 58.79  ?  404 ARG B CZ  1 
ATOM   6557 N NH1 . ARG B 2 422 ? 164.275 131.018 118.184 1.00 58.79  1  404 ARG B NH1 1 
ATOM   6558 N NH2 . ARG B 2 422 ? 166.497 130.460 118.147 1.00 58.79  ?  404 ARG B NH2 1 
ATOM   6559 N N   . TRP B 2 423 ? 163.137 123.409 116.580 1.00 63.65  ?  405 TRP B N   1 
ATOM   6560 C CA  . TRP B 2 423 ? 163.878 122.218 116.176 1.00 63.65  ?  405 TRP B CA  1 
ATOM   6561 C C   . TRP B 2 423 ? 163.356 121.633 114.868 1.00 63.65  ?  405 TRP B C   1 
ATOM   6562 O O   . TRP B 2 423 ? 164.146 121.254 113.999 1.00 63.65  ?  405 TRP B O   1 
ATOM   6563 C CB  . TRP B 2 423 ? 163.825 121.155 117.269 1.00 63.65  ?  405 TRP B CB  1 
ATOM   6564 C CG  . TRP B 2 423 ? 164.373 119.837 116.813 1.00 63.65  ?  405 TRP B CG  1 
ATOM   6565 C CD1 . TRP B 2 423 ? 165.685 119.515 116.643 1.00 63.65  ?  405 TRP B CD1 1 
ATOM   6566 C CD2 . TRP B 2 423 ? 163.625 118.671 116.456 1.00 63.65  ?  405 TRP B CD2 1 
ATOM   6567 N NE1 . TRP B 2 423 ? 165.803 118.220 116.208 1.00 63.65  ?  405 TRP B NE1 1 
ATOM   6568 C CE2 . TRP B 2 423 ? 164.551 117.679 116.084 1.00 63.65  ?  405 TRP B CE2 1 
ATOM   6569 C CE3 . TRP B 2 423 ? 162.262 118.368 116.415 1.00 63.65  ?  405 TRP B CE3 1 
ATOM   6570 C CZ2 . TRP B 2 423 ? 164.160 116.408 115.678 1.00 63.65  ?  405 TRP B CZ2 1 
ATOM   6571 C CZ3 . TRP B 2 423 ? 161.875 117.105 116.012 1.00 63.65  ?  405 TRP B CZ3 1 
ATOM   6572 C CH2 . TRP B 2 423 ? 162.820 116.141 115.648 1.00 63.65  ?  405 TRP B CH2 1 
ATOM   6573 N N   . LYS B 2 424 ? 162.035 121.548 114.707 1.00 63.24  ?  406 LYS B N   1 
ATOM   6574 C CA  . LYS B 2 424 ? 161.477 120.772 113.604 1.00 63.24  ?  406 LYS B CA  1 
ATOM   6575 C C   . LYS B 2 424 ? 161.489 121.538 112.288 1.00 63.24  ?  406 LYS B C   1 
ATOM   6576 O O   . LYS B 2 424 ? 161.810 120.964 111.242 1.00 63.24  ?  406 LYS B O   1 
ATOM   6577 C CB  . LYS B 2 424 ? 160.055 120.329 113.935 1.00 63.24  ?  406 LYS B CB  1 
ATOM   6578 C CG  . LYS B 2 424 ? 159.558 119.209 113.047 1.00 63.24  ?  406 LYS B CG  1 
ATOM   6579 C CD  . LYS B 2 424 ? 158.099 118.892 113.301 1.00 63.24  ?  406 LYS B CD  1 
ATOM   6580 C CE  . LYS B 2 424 ? 157.192 119.994 112.789 1.00 63.24  ?  406 LYS B CE  1 
ATOM   6581 N NZ  . LYS B 2 424 ? 155.767 119.570 112.790 1.00 63.24  1  406 LYS B NZ  1 
ATOM   6582 N N   . GLU B 2 425 ? 161.128 122.821 112.307 1.00 65.11  ?  407 GLU B N   1 
ATOM   6583 C CA  . GLU B 2 425 ? 161.025 123.639 111.100 1.00 65.11  ?  407 GLU B CA  1 
ATOM   6584 C C   . GLU B 2 425 ? 161.977 124.822 111.223 1.00 65.11  ?  407 GLU B C   1 
ATOM   6585 O O   . GLU B 2 425 ? 161.561 125.931 111.586 1.00 65.11  ?  407 GLU B O   1 
ATOM   6586 C CB  . GLU B 2 425 ? 159.589 124.107 110.874 1.00 65.11  ?  407 GLU B CB  1 
ATOM   6587 C CG  . GLU B 2 425 ? 158.588 122.970 110.812 1.00 65.11  ?  407 GLU B CG  1 
ATOM   6588 C CD  . GLU B 2 425 ? 157.177 123.444 110.554 1.00 65.11  ?  407 GLU B CD  1 
ATOM   6589 O OE1 . GLU B 2 425 ? 156.871 124.607 110.875 1.00 65.11  ?  407 GLU B OE1 1 
ATOM   6590 O OE2 . GLU B 2 425 ? 156.372 122.651 110.027 1.00 65.11  -1 407 GLU B OE2 1 
ATOM   6591 N N   . PRO B 2 426 ? 163.263 124.628 110.920 1.00 65.98  ?  408 PRO B N   1 
ATOM   6592 C CA  . PRO B 2 426 ? 164.233 125.714 111.076 1.00 65.98  ?  408 PRO B CA  1 
ATOM   6593 C C   . PRO B 2 426 ? 164.311 126.657 109.890 1.00 65.98  ?  408 PRO B C   1 
ATOM   6594 O O   . PRO B 2 426 ? 165.148 127.565 109.901 1.00 65.98  ?  408 PRO B O   1 
ATOM   6595 C CB  . PRO B 2 426 ? 165.549 124.953 111.253 1.00 65.98  ?  408 PRO B CB  1 
ATOM   6596 C CG  . PRO B 2 426 ? 165.371 123.750 110.406 1.00 65.98  ?  408 PRO B CG  1 
ATOM   6597 C CD  . PRO B 2 426 ? 163.905 123.395 110.435 1.00 65.98  ?  408 PRO B CD  1 
ATOM   6598 N N   . ASP B 2 427 ? 163.472 126.473 108.872 1.00 67.94  ?  409 ASP B N   1 
ATOM   6599 C CA  . ASP B 2 427 ? 163.511 127.295 107.671 1.00 67.94  ?  409 ASP B CA  1 
ATOM   6600 C C   . ASP B 2 427 ? 162.240 128.113 107.483 1.00 67.94  ?  409 ASP B C   1 
ATOM   6601 O O   . ASP B 2 427 ? 161.978 128.597 106.378 1.00 67.94  ?  409 ASP B O   1 
ATOM   6602 C CB  . ASP B 2 427 ? 163.769 126.421 106.444 1.00 67.94  ?  409 ASP B CB  1 
ATOM   6603 C CG  . ASP B 2 427 ? 165.137 125.774 106.473 1.00 67.94  ?  409 ASP B CG  1 
ATOM   6604 O OD1 . ASP B 2 427 ? 166.143 126.511 106.526 1.00 67.94  ?  409 ASP B OD1 1 
ATOM   6605 O OD2 . ASP B 2 427 ? 165.207 124.528 106.443 1.00 67.94  -1 409 ASP B OD2 1 
ATOM   6606 N N   . ARG B 2 428 ? 161.440 128.265 108.535 1.00 61.48  ?  410 ARG B N   1 
ATOM   6607 C CA  . ARG B 2 428 ? 160.322 129.190 108.491 1.00 61.48  ?  410 ARG B CA  1 
ATOM   6608 C C   . ARG B 2 428 ? 160.839 130.624 108.433 1.00 61.48  ?  410 ARG B C   1 
ATOM   6609 O O   . ARG B 2 428 ? 161.901 130.929 108.981 1.00 61.48  ?  410 ARG B O   1 
ATOM   6610 C CB  . ARG B 2 428 ? 159.434 129.029 109.718 1.00 61.48  ?  410 ARG B CB  1 
ATOM   6611 C CG  . ARG B 2 428 ? 158.586 127.789 109.736 1.00 61.48  ?  410 ARG B CG  1 
ATOM   6612 C CD  . ARG B 2 428 ? 157.691 127.796 110.956 1.00 61.48  ?  410 ARG B CD  1 
ATOM   6613 N NE  . ARG B 2 428 ? 156.685 128.849 110.889 1.00 61.48  ?  410 ARG B NE  1 
ATOM   6614 C CZ  . ARG B 2 428 ? 155.376 128.630 110.892 1.00 61.48  ?  410 ARG B CZ  1 
ATOM   6615 N NH1 . ARG B 2 428 ? 154.910 127.392 110.962 1.00 61.48  1  410 ARG B NH1 1 
ATOM   6616 N NH2 . ARG B 2 428 ? 154.531 129.647 110.830 1.00 61.48  ?  410 ARG B NH2 1 
ATOM   6617 N N   . PRO B 2 429 ? 160.118 131.519 107.762 1.00 60.24  ?  411 PRO B N   1 
ATOM   6618 C CA  . PRO B 2 429 ? 160.504 132.934 107.799 1.00 60.24  ?  411 PRO B CA  1 
ATOM   6619 C C   . PRO B 2 429 ? 160.281 133.548 109.171 1.00 60.24  ?  411 PRO B C   1 
ATOM   6620 O O   . PRO B 2 429 ? 159.142 133.742 109.606 1.00 60.24  ?  411 PRO B O   1 
ATOM   6621 C CB  . PRO B 2 429 ? 159.605 133.575 106.734 1.00 60.24  ?  411 PRO B CB  1 
ATOM   6622 C CG  . PRO B 2 429 ? 158.495 132.613 106.526 1.00 60.24  ?  411 PRO B CG  1 
ATOM   6623 C CD  . PRO B 2 429 ? 159.062 131.259 106.772 1.00 60.24  ?  411 PRO B CD  1 
ATOM   6624 N N   . ARG B 2 430 ? 161.374 133.838 109.866 1.00 57.70  ?  412 ARG B N   1 
ATOM   6625 C CA  . ARG B 2 430 ? 161.324 134.496 111.164 1.00 57.70  ?  412 ARG B CA  1 
ATOM   6626 C C   . ARG B 2 430 ? 161.859 135.910 111.020 1.00 57.70  ?  412 ARG B C   1 
ATOM   6627 O O   . ARG B 2 430 ? 163.062 136.084 110.773 1.00 57.70  ?  412 ARG B O   1 
ATOM   6628 C CB  . ARG B 2 430 ? 162.139 133.719 112.196 1.00 57.70  ?  412 ARG B CB  1 
ATOM   6629 C CG  . ARG B 2 430 ? 161.511 132.408 112.603 1.00 57.70  ?  412 ARG B CG  1 
ATOM   6630 C CD  . ARG B 2 430 ? 162.396 131.639 113.557 1.00 57.70  ?  412 ARG B CD  1 
ATOM   6631 N NE  . ARG B 2 430 ? 161.706 130.484 114.116 1.00 57.70  ?  412 ARG B NE  1 
ATOM   6632 C CZ  . ARG B 2 430 ? 161.663 129.289 113.540 1.00 57.70  ?  412 ARG B CZ  1 
ATOM   6633 N NH1 . ARG B 2 430 ? 162.273 129.086 112.384 1.00 57.70  1  412 ARG B NH1 1 
ATOM   6634 N NH2 . ARG B 2 430 ? 161.008 128.297 114.120 1.00 57.70  ?  412 ARG B NH2 1 
ATOM   6635 N N   . PRO B 2 431 ? 161.015 136.941 111.136 1.00 59.35  ?  413 PRO B N   1 
ATOM   6636 C CA  . PRO B 2 431 ? 161.519 138.318 111.017 1.00 59.35  ?  413 PRO B CA  1 
ATOM   6637 C C   . PRO B 2 431 ? 162.440 138.725 112.151 1.00 59.35  ?  413 PRO B C   1 
ATOM   6638 O O   . PRO B 2 431 ? 163.299 139.591 111.952 1.00 59.35  ?  413 PRO B O   1 
ATOM   6639 C CB  . PRO B 2 431 ? 160.239 139.163 110.995 1.00 59.35  ?  413 PRO B CB  1 
ATOM   6640 C CG  . PRO B 2 431 ? 159.198 138.298 111.592 1.00 59.35  ?  413 PRO B CG  1 
ATOM   6641 C CD  . PRO B 2 431 ? 159.548 136.898 111.227 1.00 59.35  ?  413 PRO B CD  1 
ATOM   6642 N N   . LEU B 2 432 ? 162.289 138.132 113.331 1.00 56.93  ?  414 LEU B N   1 
ATOM   6643 C CA  . LEU B 2 432 ? 163.314 138.227 114.359 1.00 56.93  ?  414 LEU B CA  1 
ATOM   6644 C C   . LEU B 2 432 ? 163.310 136.937 115.158 1.00 56.93  ?  414 LEU B C   1 
ATOM   6645 O O   . LEU B 2 432 ? 162.252 136.474 115.591 1.00 56.93  ?  414 LEU B O   1 
ATOM   6646 C CB  . LEU B 2 432 ? 163.108 139.450 115.267 1.00 56.93  ?  414 LEU B CB  1 
ATOM   6647 C CG  . LEU B 2 432 ? 161.883 139.724 116.143 1.00 56.93  ?  414 LEU B CG  1 
ATOM   6648 C CD1 . LEU B 2 432 ? 162.011 139.151 117.546 1.00 56.93  ?  414 LEU B CD1 1 
ATOM   6649 C CD2 . LEU B 2 432 ? 161.666 141.217 116.204 1.00 56.93  ?  414 LEU B CD2 1 
ATOM   6650 N N   . LYS B 2 433 ? 164.485 136.340 115.306 1.00 57.38  ?  415 LYS B N   1 
ATOM   6651 C CA  . LYS B 2 433 ? 164.672 135.183 116.162 1.00 57.38  ?  415 LYS B CA  1 
ATOM   6652 C C   . LYS B 2 433 ? 165.698 135.524 117.228 1.00 57.38  ?  415 LYS B C   1 
ATOM   6653 O O   . LYS B 2 433 ? 166.718 136.158 116.944 1.00 57.38  ?  415 LYS B O   1 
ATOM   6654 C CB  . LYS B 2 433 ? 165.113 133.948 115.366 1.00 57.38  ?  415 LYS B CB  1 
ATOM   6655 C CG  . LYS B 2 433 ? 166.240 134.181 114.383 1.00 57.38  ?  415 LYS B CG  1 
ATOM   6656 C CD  . LYS B 2 433 ? 166.365 133.021 113.412 1.00 57.38  ?  415 LYS B CD  1 
ATOM   6657 C CE  . LYS B 2 433 ? 166.546 131.700 114.135 1.00 57.38  ?  415 LYS B CE  1 
ATOM   6658 N NZ  . LYS B 2 433 ? 166.675 130.568 113.180 1.00 57.38  1  415 LYS B NZ  1 
ATOM   6659 N N   . LEU B 2 434 ? 165.410 135.128 118.458 1.00 58.55  ?  416 LEU B N   1 
ATOM   6660 C CA  . LEU B 2 434 ? 166.311 135.358 119.568 1.00 58.55  ?  416 LEU B CA  1 
ATOM   6661 C C   . LEU B 2 434 ? 167.100 134.087 119.849 1.00 58.55  ?  416 LEU B C   1 
ATOM   6662 O O   . LEU B 2 434 ? 166.980 133.080 119.150 1.00 58.55  ?  416 LEU B O   1 
ATOM   6663 C CB  . LEU B 2 434 ? 165.534 135.817 120.802 1.00 58.55  ?  416 LEU B CB  1 
ATOM   6664 C CG  . LEU B 2 434 ? 164.671 137.069 120.646 1.00 58.55  ?  416 LEU B CG  1 
ATOM   6665 C CD1 . LEU B 2 434 ? 164.086 137.477 121.983 1.00 58.55  ?  416 LEU B CD1 1 
ATOM   6666 C CD2 . LEU B 2 434 ? 165.467 138.210 120.040 1.00 58.55  ?  416 LEU B CD2 1 
ATOM   6667 N N   . SER B 2 435 ? 167.923 134.141 120.890 1.00 60.99  ?  417 SER B N   1 
ATOM   6668 C CA  . SER B 2 435 ? 168.639 132.962 121.335 1.00 60.99  ?  417 SER B CA  1 
ATOM   6669 C C   . SER B 2 435 ? 167.675 131.976 121.987 1.00 60.99  ?  417 SER B C   1 
ATOM   6670 O O   . SER B 2 435 ? 166.539 132.308 122.334 1.00 60.99  ?  417 SER B O   1 
ATOM   6671 C CB  . SER B 2 435 ? 169.746 133.350 122.311 1.00 60.99  ?  417 SER B CB  1 
ATOM   6672 O OG  . SER B 2 435 ? 170.422 132.204 122.791 1.00 60.99  ?  417 SER B OG  1 
ATOM   6673 N N   . VAL B 2 436 ? 168.148 130.747 122.178 1.00 60.53  ?  418 VAL B N   1 
ATOM   6674 C CA  . VAL B 2 436 ? 167.333 129.713 122.808 1.00 60.53  ?  418 VAL B CA  1 
ATOM   6675 C C   . VAL B 2 436 ? 167.532 129.748 124.317 1.00 60.53  ?  418 VAL B C   1 
ATOM   6676 O O   . VAL B 2 436 ? 167.073 128.854 125.033 1.00 60.53  ?  418 VAL B O   1 
ATOM   6677 C CB  . VAL B 2 436 ? 167.657 128.320 122.242 1.00 60.53  ?  418 VAL B CB  1 
ATOM   6678 C CG1 . VAL B 2 436 ? 167.168 128.206 120.814 1.00 60.53  ?  418 VAL B CG1 1 
ATOM   6679 C CG2 . VAL B 2 436 ? 169.145 128.054 122.318 1.00 60.53  ?  418 VAL B CG2 1 
ATOM   6680 N N   . PHE B 2 437 ? 168.222 130.777 124.808 1.00 58.73  ?  419 PHE B N   1 
ATOM   6681 C CA  . PHE B 2 437 ? 168.383 130.962 126.244 1.00 58.73  ?  419 PHE B CA  1 
ATOM   6682 C C   . PHE B 2 437 ? 167.061 131.347 126.897 1.00 58.73  ?  419 PHE B C   1 
ATOM   6683 O O   . PHE B 2 437 ? 166.665 130.761 127.916 1.00 58.73  ?  419 PHE B O   1 
ATOM   6684 C CB  . PHE B 2 437 ? 169.452 132.025 126.501 1.00 58.73  ?  419 PHE B CB  1 
ATOM   6685 C CG  . PHE B 2 437 ? 169.626 132.377 127.947 1.00 58.73  ?  419 PHE B CG  1 
ATOM   6686 C CD1 . PHE B 2 437 ? 170.280 131.512 128.807 1.00 58.73  ?  419 PHE B CD1 1 
ATOM   6687 C CD2 . PHE B 2 437 ? 169.149 133.579 128.443 1.00 58.73  ?  419 PHE B CD2 1 
ATOM   6688 C CE1 . PHE B 2 437 ? 170.445 131.833 130.138 1.00 58.73  ?  419 PHE B CE1 1 
ATOM   6689 C CE2 . PHE B 2 437 ? 169.309 133.906 129.774 1.00 58.73  ?  419 PHE B CE2 1 
ATOM   6690 C CZ  . PHE B 2 437 ? 169.958 133.031 130.622 1.00 58.73  ?  419 PHE B CZ  1 
ATOM   6691 N N   . PHE B 2 438 ? 166.367 132.328 126.314 1.00 58.29  ?  420 PHE B N   1 
ATOM   6692 C CA  . PHE B 2 438 ? 165.098 132.797 126.871 1.00 58.29  ?  420 PHE B CA  1 
ATOM   6693 C C   . PHE B 2 438 ? 163.981 131.749 126.905 1.00 58.29  ?  420 PHE B C   1 
ATOM   6694 O O   . PHE B 2 438 ? 163.312 131.663 127.952 1.00 58.29  ?  420 PHE B O   1 
ATOM   6695 C CB  . PHE B 2 438 ? 164.627 134.062 126.132 1.00 58.29  ?  420 PHE B CB  1 
ATOM   6696 C CG  . PHE B 2 438 ? 165.700 135.085 125.914 1.00 58.29  ?  420 PHE B CG  1 
ATOM   6697 C CD1 . PHE B 2 438 ? 166.053 135.964 126.923 1.00 58.29  ?  420 PHE B CD1 1 
ATOM   6698 C CD2 . PHE B 2 438 ? 166.336 135.187 124.688 1.00 58.29  ?  420 PHE B CD2 1 
ATOM   6699 C CE1 . PHE B 2 438 ? 167.034 136.914 126.718 1.00 58.29  ?  420 PHE B CE1 1 
ATOM   6700 C CE2 . PHE B 2 438 ? 167.317 136.133 124.479 1.00 58.29  ?  420 PHE B CE2 1 
ATOM   6701 C CZ  . PHE B 2 438 ? 167.665 136.996 125.495 1.00 58.29  ?  420 PHE B CZ  1 
ATOM   6702 N N   . PRO B 2 439 ? 163.711 130.941 125.856 1.00 57.88  ?  421 PRO B N   1 
ATOM   6703 C CA  . PRO B 2 439 ? 162.666 129.916 126.020 1.00 57.88  ?  421 PRO B CA  1 
ATOM   6704 C C   . PRO B 2 439 ? 163.024 128.824 127.011 1.00 57.88  ?  421 PRO B C   1 
ATOM   6705 O O   . PRO B 2 439 ? 162.122 128.308 127.678 1.00 57.88  ?  421 PRO B O   1 
ATOM   6706 C CB  . PRO B 2 439 ? 162.497 129.354 124.602 1.00 57.88  ?  421 PRO B CB  1 
ATOM   6707 C CG  . PRO B 2 439 ? 162.969 130.418 123.729 1.00 57.88  ?  421 PRO B CG  1 
ATOM   6708 C CD  . PRO B 2 439 ? 164.136 130.972 124.440 1.00 57.88  ?  421 PRO B CD  1 
ATOM   6709 N N   . ILE B 2 440 ? 164.307 128.501 127.176 1.00 58.71  ?  422 ILE B N   1 
ATOM   6710 C CA  . ILE B 2 440 ? 164.693 127.483 128.147 1.00 58.71  ?  422 ILE B CA  1 
ATOM   6711 C C   . ILE B 2 440 ? 164.516 128.000 129.574 1.00 58.71  ?  422 ILE B C   1 
ATOM   6712 O O   . ILE B 2 440 ? 163.954 127.300 130.435 1.00 58.71  ?  422 ILE B O   1 
ATOM   6713 C CB  . ILE B 2 440 ? 166.132 127.010 127.867 1.00 58.71  ?  422 ILE B CB  1 
ATOM   6714 C CG1 . ILE B 2 440 ? 166.153 126.127 126.620 1.00 58.71  ?  422 ILE B CG1 1 
ATOM   6715 C CG2 . ILE B 2 440 ? 166.700 126.234 129.038 1.00 58.71  ?  422 ILE B CG2 1 
ATOM   6716 C CD1 . ILE B 2 440 ? 167.533 125.747 126.163 1.00 58.71  ?  422 ILE B CD1 1 
ATOM   6717 N N   . VAL B 2 441 ? 164.944 129.240 129.843 1.00 59.24  ?  423 VAL B N   1 
ATOM   6718 C CA  . VAL B 2 441 ? 164.800 129.752 131.205 1.00 59.24  ?  423 VAL B CA  1 
ATOM   6719 C C   . VAL B 2 441 ? 163.337 130.055 131.524 1.00 59.24  ?  423 VAL B C   1 
ATOM   6720 O O   . VAL B 2 441 ? 162.899 129.886 132.669 1.00 59.24  ?  423 VAL B O   1 
ATOM   6721 C CB  . VAL B 2 441 ? 165.715 130.969 131.456 1.00 59.24  ?  423 VAL B CB  1 
ATOM   6722 C CG1 . VAL B 2 441 ? 167.167 130.581 131.256 1.00 59.24  ?  423 VAL B CG1 1 
ATOM   6723 C CG2 . VAL B 2 441 ? 165.346 132.158 130.591 1.00 59.24  ?  423 VAL B CG2 1 
ATOM   6724 N N   . PHE B 2 442 ? 162.529 130.416 130.520 1.00 57.68  ?  424 PHE B N   1 
ATOM   6725 C CA  . PHE B 2 442 ? 161.116 130.586 130.823 1.00 57.68  ?  424 PHE B CA  1 
ATOM   6726 C C   . PHE B 2 442 ? 160.372 129.263 130.913 1.00 57.68  ?  424 PHE B C   1 
ATOM   6727 O O   . PHE B 2 442 ? 159.354 129.196 131.605 1.00 57.68  ?  424 PHE B O   1 
ATOM   6728 C CB  . PHE B 2 442 ? 160.428 131.491 129.807 1.00 57.68  ?  424 PHE B CB  1 
ATOM   6729 C CG  . PHE B 2 442 ? 159.166 132.099 130.332 1.00 57.68  ?  424 PHE B CG  1 
ATOM   6730 C CD1 . PHE B 2 442 ? 159.208 132.973 131.404 1.00 57.68  ?  424 PHE B CD1 1 
ATOM   6731 C CD2 . PHE B 2 442 ? 157.937 131.765 129.790 1.00 57.68  ?  424 PHE B CD2 1 
ATOM   6732 C CE1 . PHE B 2 442 ? 158.051 133.525 131.911 1.00 57.68  ?  424 PHE B CE1 1 
ATOM   6733 C CE2 . PHE B 2 442 ? 156.774 132.315 130.294 1.00 57.68  ?  424 PHE B CE2 1 
ATOM   6734 C CZ  . PHE B 2 442 ? 156.833 133.194 131.356 1.00 57.68  ?  424 PHE B CZ  1 
ATOM   6735 N N   . CYS B 2 443 ? 160.869 128.207 130.262 1.00 61.82  ?  425 CYS B N   1 
ATOM   6736 C CA  . CYS B 2 443 ? 160.324 126.873 130.484 1.00 61.82  ?  425 CYS B CA  1 
ATOM   6737 C C   . CYS B 2 443 ? 160.569 126.406 131.912 1.00 61.82  ?  425 CYS B C   1 
ATOM   6738 O O   . CYS B 2 443 ? 159.669 125.848 132.555 1.00 61.82  ?  425 CYS B O   1 
ATOM   6739 C CB  . CYS B 2 443 ? 160.938 125.889 129.493 1.00 61.82  ?  425 CYS B CB  1 
ATOM   6740 S SG  . CYS B 2 443 ? 160.151 124.280 129.490 1.00 61.82  ?  425 CYS B SG  1 
ATOM   6741 N N   . LEU B 2 444 ? 161.780 126.639 132.427 1.00 60.98  ?  426 LEU B N   1 
ATOM   6742 C CA  . LEU B 2 444 ? 162.063 126.305 133.823 1.00 60.98  ?  426 LEU B CA  1 
ATOM   6743 C C   . LEU B 2 444 ? 161.244 127.165 134.781 1.00 60.98  ?  426 LEU B C   1 
ATOM   6744 O O   . LEU B 2 444 ? 160.772 126.675 135.818 1.00 60.98  ?  426 LEU B O   1 
ATOM   6745 C CB  . LEU B 2 444 ? 163.554 126.457 134.107 1.00 60.98  ?  426 LEU B CB  1 
ATOM   6746 C CG  . LEU B 2 444 ? 164.480 125.546 133.306 1.00 60.98  ?  426 LEU B CG  1 
ATOM   6747 C CD1 . LEU B 2 444 ? 165.925 125.855 133.636 1.00 60.98  ?  426 LEU B CD1 1 
ATOM   6748 C CD2 . LEU B 2 444 ? 164.163 124.090 133.580 1.00 60.98  ?  426 LEU B CD2 1 
ATOM   6749 N N   . CYS B 2 445 ? 161.036 128.439 134.431 1.00 62.46  ?  427 CYS B N   1 
ATOM   6750 C CA  . CYS B 2 445 ? 160.210 129.321 135.251 1.00 62.46  ?  427 CYS B CA  1 
ATOM   6751 C C   . CYS B 2 445 ? 158.752 128.870 135.275 1.00 62.46  ?  427 CYS B C   1 
ATOM   6752 O O   . CYS B 2 445 ? 158.103 128.921 136.324 1.00 62.46  ?  427 CYS B O   1 
ATOM   6753 C CB  . CYS B 2 445 ? 160.326 130.758 134.741 1.00 62.46  ?  427 CYS B CB  1 
ATOM   6754 S SG  . CYS B 2 445 ? 159.143 131.921 135.447 1.00 62.46  ?  427 CYS B SG  1 
ATOM   6755 N N   . THR B 2 446 ? 158.223 128.394 134.147 1.00 60.47  ?  428 THR B N   1 
ATOM   6756 C CA  . THR B 2 446 ? 156.843 127.917 134.140 1.00 60.47  ?  428 THR B CA  1 
ATOM   6757 C C   . THR B 2 446 ? 156.694 126.560 134.815 1.00 60.47  ?  428 THR B C   1 
ATOM   6758 O O   . THR B 2 446 ? 155.628 126.268 135.368 1.00 60.47  ?  428 THR B O   1 
ATOM   6759 C CB  . THR B 2 446 ? 156.304 127.845 132.715 1.00 60.47  ?  428 THR B CB  1 
ATOM   6760 O OG1 . THR B 2 446 ? 157.253 127.178 131.874 1.00 60.47  ?  428 THR B OG1 1 
ATOM   6761 C CG2 . THR B 2 446 ? 156.039 129.236 132.182 1.00 60.47  ?  428 THR B CG2 1 
ATOM   6762 N N   . ILE B 2 447 ? 157.739 125.727 134.796 1.00 61.66  ?  429 ILE B N   1 
ATOM   6763 C CA  . ILE B 2 447 ? 157.712 124.491 135.578 1.00 61.66  ?  429 ILE B CA  1 
ATOM   6764 C C   . ILE B 2 447 ? 157.683 124.808 137.072 1.00 61.66  ?  429 ILE B C   1 
ATOM   6765 O O   . ILE B 2 447 ? 156.931 124.188 137.838 1.00 61.66  ?  429 ILE B O   1 
ATOM   6766 C CB  . ILE B 2 447 ? 158.901 123.591 135.186 1.00 61.66  ?  429 ILE B CB  1 
ATOM   6767 C CG1 . ILE B 2 447 ? 158.635 122.937 133.831 1.00 61.66  ?  429 ILE B CG1 1 
ATOM   6768 C CG2 . ILE B 2 447 ? 159.157 122.505 136.218 1.00 61.66  ?  429 ILE B CG2 1 
ATOM   6769 C CD1 . ILE B 2 447 ? 159.774 122.089 133.324 1.00 61.66  ?  429 ILE B CD1 1 
ATOM   6770 N N   . PHE B 2 448 ? 158.460 125.811 137.500 1.00 62.13  ?  430 PHE B N   1 
ATOM   6771 C CA  . PHE B 2 448 ? 158.367 126.291 138.879 1.00 62.13  ?  430 PHE B CA  1 
ATOM   6772 C C   . PHE B 2 448 ? 156.993 126.887 139.174 1.00 62.13  ?  430 PHE B C   1 
ATOM   6773 O O   . PHE B 2 448 ? 156.463 126.729 140.279 1.00 62.13  ?  430 PHE B O   1 
ATOM   6774 C CB  . PHE B 2 448 ? 159.472 127.317 139.147 1.00 62.13  ?  430 PHE B CB  1 
ATOM   6775 C CG  . PHE B 2 448 ? 159.165 128.281 140.266 1.00 62.13  ?  430 PHE B CG  1 
ATOM   6776 C CD1 . PHE B 2 448 ? 159.197 127.866 141.587 1.00 62.13  ?  430 PHE B CD1 1 
ATOM   6777 C CD2 . PHE B 2 448 ? 158.862 129.608 139.995 1.00 62.13  ?  430 PHE B CD2 1 
ATOM   6778 C CE1 . PHE B 2 448 ? 158.919 128.747 142.612 1.00 62.13  ?  430 PHE B CE1 1 
ATOM   6779 C CE2 . PHE B 2 448 ? 158.583 130.493 141.019 1.00 62.13  ?  430 PHE B CE2 1 
ATOM   6780 C CZ  . PHE B 2 448 ? 158.613 130.061 142.327 1.00 62.13  ?  430 PHE B CZ  1 
ATOM   6781 N N   . LEU B 2 449 ? 156.396 127.563 138.191 1.00 61.18  ?  431 LEU B N   1 
ATOM   6782 C CA  . LEU B 2 449 ? 155.099 128.198 138.395 1.00 61.18  ?  431 LEU B CA  1 
ATOM   6783 C C   . LEU B 2 449 ? 153.971 127.182 138.496 1.00 61.18  ?  431 LEU B C   1 
ATOM   6784 O O   . LEU B 2 449 ? 152.956 127.459 139.140 1.00 61.18  ?  431 LEU B O   1 
ATOM   6785 C CB  . LEU B 2 449 ? 154.811 129.177 137.262 1.00 61.18  ?  431 LEU B CB  1 
ATOM   6786 C CG  . LEU B 2 449 ? 155.309 130.609 137.429 1.00 61.18  ?  431 LEU B CG  1 
ATOM   6787 C CD1 . LEU B 2 449 ? 155.440 131.264 136.072 1.00 61.18  ?  431 LEU B CD1 1 
ATOM   6788 C CD2 . LEU B 2 449 ? 154.367 131.393 138.312 1.00 61.18  ?  431 LEU B CD2 1 
ATOM   6789 N N   . VAL B 2 450 ? 154.109 126.021 137.857 1.00 61.84  ?  432 VAL B N   1 
ATOM   6790 C CA  . VAL B 2 450 ? 153.074 125.000 137.984 1.00 61.84  ?  432 VAL B CA  1 
ATOM   6791 C C   . VAL B 2 450 ? 153.357 124.004 139.104 1.00 61.84  ?  432 VAL B C   1 
ATOM   6792 O O   . VAL B 2 450 ? 152.438 123.289 139.525 1.00 61.84  ?  432 VAL B O   1 
ATOM   6793 C CB  . VAL B 2 450 ? 152.849 124.233 136.667 1.00 61.84  ?  432 VAL B CB  1 
ATOM   6794 C CG1 . VAL B 2 450 ? 152.456 125.184 135.561 1.00 61.84  ?  432 VAL B CG1 1 
ATOM   6795 C CG2 . VAL B 2 450 ? 154.077 123.432 136.280 1.00 61.84  ?  432 VAL B CG2 1 
ATOM   6796 N N   . ALA B 2 451 ? 154.595 123.939 139.605 1.00 63.57  ?  433 ALA B N   1 
ATOM   6797 C CA  . ALA B 2 451 ? 154.893 123.018 140.697 1.00 63.57  ?  433 ALA B CA  1 
ATOM   6798 C C   . ALA B 2 451 ? 154.313 123.491 142.022 1.00 63.57  ?  433 ALA B C   1 
ATOM   6799 O O   . ALA B 2 451 ? 153.993 122.664 142.881 1.00 63.57  ?  433 ALA B O   1 
ATOM   6800 C CB  . ALA B 2 451 ? 156.402 122.828 140.826 1.00 63.57  ?  433 ALA B CB  1 
ATOM   6801 N N   . VAL B 2 452 ? 154.171 124.799 142.209 1.00 65.01  ?  434 VAL B N   1 
ATOM   6802 C CA  . VAL B 2 452 ? 153.649 125.366 143.455 1.00 65.01  ?  434 VAL B CA  1 
ATOM   6803 C C   . VAL B 2 452 ? 152.166 125.040 143.675 1.00 65.01  ?  434 VAL B C   1 
ATOM   6804 O O   . VAL B 2 452 ? 151.833 124.605 144.787 1.00 65.01  ?  434 VAL B O   1 
ATOM   6805 C CB  . VAL B 2 452 ? 153.934 126.880 143.529 1.00 65.01  ?  434 VAL B CB  1 
ATOM   6806 C CG1 . VAL B 2 452 ? 153.348 127.487 144.789 1.00 65.01  ?  434 VAL B CG1 1 
ATOM   6807 C CG2 . VAL B 2 452 ? 155.424 127.134 143.479 1.00 65.01  ?  434 VAL B CG2 1 
ATOM   6808 N N   . PRO B 2 453 ? 151.236 125.176 142.717 1.00 64.87  ?  435 PRO B N   1 
ATOM   6809 C CA  . PRO B 2 453 ? 149.868 124.729 143.008 1.00 64.87  ?  435 PRO B CA  1 
ATOM   6810 C C   . PRO B 2 453 ? 149.665 123.222 142.959 1.00 64.87  ?  435 PRO B C   1 
ATOM   6811 O O   . PRO B 2 453 ? 148.567 122.763 143.283 1.00 64.87  ?  435 PRO B O   1 
ATOM   6812 C CB  . PRO B 2 453 ? 149.029 125.425 141.921 1.00 64.87  ?  435 PRO B CB  1 
ATOM   6813 C CG  . PRO B 2 453 ? 149.895 126.449 141.348 1.00 64.87  ?  435 PRO B CG  1 
ATOM   6814 C CD  . PRO B 2 453 ? 151.240 125.858 141.407 1.00 64.87  ?  435 PRO B CD  1 
ATOM   6815 N N   . LEU B 2 454 ? 150.662 122.431 142.571 1.00 66.61  ?  436 LEU B N   1 
ATOM   6816 C CA  . LEU B 2 454 ? 150.497 120.984 142.636 1.00 66.61  ?  436 LEU B CA  1 
ATOM   6817 C C   . LEU B 2 454 ? 150.907 120.409 143.984 1.00 66.61  ?  436 LEU B C   1 
ATOM   6818 O O   . LEU B 2 454 ? 150.296 119.444 144.450 1.00 66.61  ?  436 LEU B O   1 
ATOM   6819 C CB  . LEU B 2 454 ? 151.295 120.295 141.531 1.00 66.61  ?  436 LEU B CB  1 
ATOM   6820 C CG  . LEU B 2 454 ? 150.677 120.285 140.139 1.00 66.61  ?  436 LEU B CG  1 
ATOM   6821 C CD1 . LEU B 2 454 ? 151.634 119.646 139.157 1.00 66.61  ?  436 LEU B CD1 1 
ATOM   6822 C CD2 . LEU B 2 454 ? 149.361 119.536 140.162 1.00 66.61  ?  436 LEU B CD2 1 
ATOM   6823 N N   . TYR B 2 455 ? 151.933 120.969 144.621 1.00 72.35  ?  437 TYR B N   1 
ATOM   6824 C CA  . TYR B 2 455 ? 152.349 120.462 145.927 1.00 72.35  ?  437 TYR B CA  1 
ATOM   6825 C C   . TYR B 2 455 ? 151.406 120.970 147.011 1.00 72.35  ?  437 TYR B C   1 
ATOM   6826 O O   . TYR B 2 455 ? 150.692 120.191 147.648 1.00 72.35  ?  437 TYR B O   1 
ATOM   6827 C CB  . TYR B 2 455 ? 153.795 120.876 146.216 1.00 72.35  ?  437 TYR B CB  1 
ATOM   6828 C CG  . TYR B 2 455 ? 154.352 120.317 147.505 1.00 72.35  ?  437 TYR B CG  1 
ATOM   6829 C CD1 . TYR B 2 455 ? 154.845 119.020 147.563 1.00 72.35  ?  437 TYR B CD1 1 
ATOM   6830 C CD2 . TYR B 2 455 ? 154.387 121.085 148.662 1.00 72.35  ?  437 TYR B CD2 1 
ATOM   6831 C CE1 . TYR B 2 455 ? 155.356 118.503 148.737 1.00 72.35  ?  437 TYR B CE1 1 
ATOM   6832 C CE2 . TYR B 2 455 ? 154.894 120.576 149.841 1.00 72.35  ?  437 TYR B CE2 1 
ATOM   6833 C CZ  . TYR B 2 455 ? 155.377 119.285 149.871 1.00 72.35  ?  437 TYR B CZ  1 
ATOM   6834 O OH  . TYR B 2 455 ? 155.884 118.774 151.042 1.00 72.35  ?  437 TYR B OH  1 
ATOM   6835 N N   . SER B 2 456 ? 151.386 122.279 147.221 1.00 72.49  ?  438 SER B N   1 
ATOM   6836 C CA  . SER B 2 456 ? 150.380 122.893 148.067 1.00 72.49  ?  438 SER B CA  1 
ATOM   6837 C C   . SER B 2 456 ? 149.154 123.213 147.229 1.00 72.49  ?  438 SER B C   1 
ATOM   6838 O O   . SER B 2 456 ? 149.268 123.456 146.026 1.00 72.49  ?  438 SER B O   1 
ATOM   6839 C CB  . SER B 2 456 ? 150.921 124.167 148.708 1.00 72.49  ?  438 SER B CB  1 
ATOM   6840 O OG  . SER B 2 456 ? 149.935 124.796 149.503 1.00 72.49  ?  438 SER B OG  1 
ATOM   6841 N N   . ASP B 2 457 ? 147.981 123.200 147.881 1.00 70.78  ?  439 ASP B N   1 
ATOM   6842 C CA  . ASP B 2 457 ? 146.675 123.445 147.249 1.00 70.78  ?  439 ASP B CA  1 
ATOM   6843 C C   . ASP B 2 457 ? 146.439 122.438 146.119 1.00 70.78  ?  439 ASP B C   1 
ATOM   6844 O O   . ASP B 2 457 ? 146.236 122.791 144.959 1.00 70.78  ?  439 ASP B O   1 
ATOM   6845 C CB  . ASP B 2 457 ? 146.561 124.908 146.777 1.00 70.78  ?  439 ASP B CB  1 
ATOM   6846 C CG  . ASP B 2 457 ? 145.144 125.318 146.392 1.00 70.78  ?  439 ASP B CG  1 
ATOM   6847 O OD1 . ASP B 2 457 ? 144.760 125.166 145.215 1.00 70.78  ?  439 ASP B OD1 1 
ATOM   6848 O OD2 . ASP B 2 457 ? 144.412 125.813 147.273 1.00 70.78  -1 439 ASP B OD2 1 
ATOM   6849 N N   . THR B 2 458 ? 146.510 121.155 146.470 1.00 67.67  ?  440 THR B N   1 
ATOM   6850 C CA  . THR B 2 458 ? 146.536 120.089 145.478 1.00 67.67  ?  440 THR B CA  1 
ATOM   6851 C C   . THR B 2 458 ? 145.158 119.563 145.104 1.00 67.67  ?  440 THR B C   1 
ATOM   6852 O O   . THR B 2 458 ? 145.030 118.894 144.074 1.00 67.67  ?  440 THR B O   1 
ATOM   6853 C CB  . THR B 2 458 ? 147.406 118.928 145.976 1.00 67.67  ?  440 THR B CB  1 
ATOM   6854 O OG1 . THR B 2 458 ? 147.531 117.940 144.947 1.00 67.67  ?  440 THR B OG1 1 
ATOM   6855 C CG2 . THR B 2 458 ? 146.812 118.294 147.219 1.00 67.67  ?  440 THR B CG2 1 
ATOM   6856 N N   . ILE B 2 459 ? 144.129 119.841 145.902 1.00 67.37  ?  441 ILE B N   1 
ATOM   6857 C CA  . ILE B 2 459 ? 142.796 119.352 145.573 1.00 67.37  ?  441 ILE B CA  1 
ATOM   6858 C C   . ILE B 2 459 ? 142.157 120.226 144.503 1.00 67.37  ?  441 ILE B C   1 
ATOM   6859 O O   . ILE B 2 459 ? 141.468 119.726 143.608 1.00 67.37  ?  441 ILE B O   1 
ATOM   6860 C CB  . ILE B 2 459 ? 141.933 119.276 146.846 1.00 67.37  ?  441 ILE B CB  1 
ATOM   6861 C CG1 . ILE B 2 459 ? 142.651 118.464 147.924 1.00 67.37  ?  441 ILE B CG1 1 
ATOM   6862 C CG2 . ILE B 2 459 ? 140.581 118.644 146.558 1.00 67.37  ?  441 ILE B CG2 1 
ATOM   6863 C CD1 . ILE B 2 459 ? 142.847 117.010 147.569 1.00 67.37  ?  441 ILE B CD1 1 
ATOM   6864 N N   . ASN B 2 460 ? 142.397 121.539 144.561 1.00 66.87  ?  442 ASN B N   1 
ATOM   6865 C CA  . ASN B 2 460 ? 141.795 122.454 143.595 1.00 66.87  ?  442 ASN B CA  1 
ATOM   6866 C C   . ASN B 2 460 ? 142.416 122.316 142.211 1.00 66.87  ?  442 ASN B C   1 
ATOM   6867 O O   . ASN B 2 460 ? 141.745 122.574 141.204 1.00 66.87  ?  442 ASN B O   1 
ATOM   6868 C CB  . ASN B 2 460 ? 141.925 123.891 144.090 1.00 66.87  ?  442 ASN B CB  1 
ATOM   6869 C CG  . ASN B 2 460 ? 141.373 124.076 145.483 1.00 66.87  ?  442 ASN B CG  1 
ATOM   6870 O OD1 . ASN B 2 460 ? 140.585 123.265 145.963 1.00 66.87  ?  442 ASN B OD1 1 
ATOM   6871 N ND2 . ASN B 2 460 ? 141.777 125.153 146.140 1.00 66.87  ?  442 ASN B ND2 1 
ATOM   6872 N N   . SER B 2 461 ? 143.682 121.903 142.138 1.00 63.99  ?  443 SER B N   1 
ATOM   6873 C CA  . SER B 2 461 ? 144.330 121.742 140.842 1.00 63.99  ?  443 SER B CA  1 
ATOM   6874 C C   . SER B 2 461 ? 143.773 120.541 140.088 1.00 63.99  ?  443 SER B C   1 
ATOM   6875 O O   . SER B 2 461 ? 143.617 120.590 138.864 1.00 63.99  ?  443 SER B O   1 
ATOM   6876 C CB  . SER B 2 461 ? 145.839 121.615 141.027 1.00 63.99  ?  443 SER B CB  1 
ATOM   6877 O OG  . SER B 2 461 ? 146.392 122.840 141.464 1.00 63.99  ?  443 SER B OG  1 
ATOM   6878 N N   . LEU B 2 462 ? 143.451 119.460 140.801 1.00 62.82  ?  444 LEU B N   1 
ATOM   6879 C CA  . LEU B 2 462 ? 142.829 118.310 140.153 1.00 62.82  ?  444 LEU B CA  1 
ATOM   6880 C C   . LEU B 2 462 ? 141.405 118.619 139.709 1.00 62.82  ?  444 LEU B C   1 
ATOM   6881 O O   . LEU B 2 462 ? 140.956 118.114 138.673 1.00 62.82  ?  444 LEU B O   1 
ATOM   6882 C CB  . LEU B 2 462 ? 142.851 117.108 141.092 1.00 62.82  ?  444 LEU B CB  1 
ATOM   6883 C CG  . LEU B 2 462 ? 144.247 116.684 141.547 1.00 62.82  ?  444 LEU B CG  1 
ATOM   6884 C CD1 . LEU B 2 462 ? 144.166 115.545 142.544 1.00 62.82  ?  444 LEU B CD1 1 
ATOM   6885 C CD2 . LEU B 2 462 ? 145.100 116.295 140.355 1.00 62.82  ?  444 LEU B CD2 1 
ATOM   6886 N N   . ILE B 2 463 ? 140.697 119.464 140.460 1.00 60.14  ?  445 ILE B N   1 
ATOM   6887 C CA  . ILE B 2 463 ? 139.382 119.936 140.038 1.00 60.14  ?  445 ILE B CA  1 
ATOM   6888 C C   . ILE B 2 463 ? 139.504 120.790 138.781 1.00 60.14  ?  445 ILE B C   1 
ATOM   6889 O O   . ILE B 2 463 ? 138.679 120.693 137.864 1.00 60.14  ?  445 ILE B O   1 
ATOM   6890 C CB  . ILE B 2 463 ? 138.708 120.691 141.199 1.00 60.14  ?  445 ILE B CB  1 
ATOM   6891 C CG1 . ILE B 2 463 ? 138.418 119.729 142.349 1.00 60.14  ?  445 ILE B CG1 1 
ATOM   6892 C CG2 . ILE B 2 463 ? 137.417 121.358 140.767 1.00 60.14  ?  445 ILE B CG2 1 
ATOM   6893 C CD1 . ILE B 2 463 ? 138.008 120.415 143.625 1.00 60.14  ?  445 ILE B CD1 1 
ATOM   6894 N N   . GLY B 2 464 ? 140.566 121.593 138.689 1.00 59.24  ?  446 GLY B N   1 
ATOM   6895 C CA  . GLY B 2 464 ? 140.791 122.367 137.479 1.00 59.24  ?  446 GLY B CA  1 
ATOM   6896 C C   . GLY B 2 464 ? 141.157 121.515 136.277 1.00 59.24  ?  446 GLY B C   1 
ATOM   6897 O O   . GLY B 2 464 ? 140.746 121.810 135.151 1.00 59.24  ?  446 GLY B O   1 
ATOM   6898 N N   . ILE B 2 465 ? 141.923 120.444 136.499 1.00 57.27  ?  447 ILE B N   1 
ATOM   6899 C CA  . ILE B 2 465 ? 142.243 119.510 135.421 1.00 57.27  ?  447 ILE B CA  1 
ATOM   6900 C C   . ILE B 2 465 ? 140.987 118.774 134.958 1.00 57.27  ?  447 ILE B C   1 
ATOM   6901 O O   . ILE B 2 465 ? 140.791 118.544 133.758 1.00 57.27  ?  447 ILE B O   1 
ATOM   6902 C CB  . ILE B 2 465 ? 143.355 118.545 135.877 1.00 57.27  ?  447 ILE B CB  1 
ATOM   6903 C CG1 . ILE B 2 465 ? 144.672 119.299 136.035 1.00 57.27  ?  447 ILE B CG1 1 
ATOM   6904 C CG2 . ILE B 2 465 ? 143.570 117.408 134.893 1.00 57.27  ?  447 ILE B CG2 1 
ATOM   6905 C CD1 . ILE B 2 465 ? 145.743 118.495 136.720 1.00 57.27  ?  447 ILE B CD1 1 
ATOM   6906 N N   . ALA B 2 466 ? 140.089 118.449 135.893 1.00 56.98  ?  448 ALA B N   1 
ATOM   6907 C CA  . ALA B 2 466 ? 138.819 117.827 135.524 1.00 56.98  ?  448 ALA B CA  1 
ATOM   6908 C C   . ALA B 2 466 ? 137.930 118.788 134.739 1.00 56.98  ?  448 ALA B C   1 
ATOM   6909 O O   . ALA B 2 466 ? 137.258 118.379 133.783 1.00 56.98  ?  448 ALA B O   1 
ATOM   6910 C CB  . ALA B 2 466 ? 138.097 117.331 136.774 1.00 56.98  ?  448 ALA B CB  1 
ATOM   6911 N N   . ILE B 2 467 ? 137.935 120.070 135.116 1.00 55.58  ?  449 ILE B N   1 
ATOM   6912 C CA  . ILE B 2 467 ? 137.185 121.086 134.378 1.00 55.58  ?  449 ILE B CA  1 
ATOM   6913 C C   . ILE B 2 467 ? 137.743 121.246 132.968 1.00 55.58  ?  449 ILE B C   1 
ATOM   6914 O O   . ILE B 2 467 ? 136.989 121.316 131.989 1.00 55.58  ?  449 ILE B O   1 
ATOM   6915 C CB  . ILE B 2 467 ? 137.200 122.415 135.160 1.00 55.58  ?  449 ILE B CB  1 
ATOM   6916 C CG1 . ILE B 2 467 ? 136.246 122.348 136.349 1.00 55.58  ?  449 ILE B CG1 1 
ATOM   6917 C CG2 . ILE B 2 467 ? 136.830 123.596 134.279 1.00 55.58  ?  449 ILE B CG2 1 
ATOM   6918 C CD1 . ILE B 2 467 ? 136.409 123.493 137.311 1.00 55.58  ?  449 ILE B CD1 1 
ATOM   6919 N N   . ALA B 2 468 ? 139.073 121.248 132.837 1.00 55.35  ?  450 ALA B N   1 
ATOM   6920 C CA  . ALA B 2 468 ? 139.696 121.388 131.524 1.00 55.35  ?  450 ALA B CA  1 
ATOM   6921 C C   . ALA B 2 468 ? 139.496 120.151 130.655 1.00 55.35  ?  450 ALA B C   1 
ATOM   6922 O O   . ALA B 2 468 ? 139.463 120.263 129.426 1.00 55.35  ?  450 ALA B O   1 
ATOM   6923 C CB  . ALA B 2 468 ? 141.186 121.687 131.681 1.00 55.35  ?  450 ALA B CB  1 
ATOM   6924 N N   . LEU B 2 469 ? 139.364 118.975 131.261 1.00 56.58  ?  451 LEU B N   1 
ATOM   6925 C CA  . LEU B 2 469 ? 139.111 117.755 130.505 1.00 56.58  ?  451 LEU B CA  1 
ATOM   6926 C C   . LEU B 2 469 ? 137.630 117.482 130.288 1.00 56.58  ?  451 LEU B C   1 
ATOM   6927 O O   . LEU B 2 469 ? 137.291 116.536 129.572 1.00 56.58  ?  451 LEU B O   1 
ATOM   6928 C CB  . LEU B 2 469 ? 139.741 116.552 131.210 1.00 56.58  ?  451 LEU B CB  1 
ATOM   6929 C CG  . LEU B 2 469 ? 141.261 116.436 131.140 1.00 56.58  ?  451 LEU B CG  1 
ATOM   6930 C CD1 . LEU B 2 469 ? 141.729 115.225 131.921 1.00 56.58  ?  451 LEU B CD1 1 
ATOM   6931 C CD2 . LEU B 2 469 ? 141.719 116.356 129.702 1.00 56.58  ?  451 LEU B CD2 1 
ATOM   6932 N N   . SER B 2 470 ? 136.748 118.273 130.881 1.00 56.88  ?  452 SER B N   1 
ATOM   6933 C CA  . SER B 2 470 ? 135.307 118.110 130.687 1.00 56.88  ?  452 SER B CA  1 
ATOM   6934 C C   . SER B 2 470 ? 134.810 118.453 129.272 1.00 56.88  ?  452 SER B C   1 
ATOM   6935 O O   . SER B 2 470 ? 133.590 118.414 129.098 1.00 56.88  ?  452 SER B O   1 
ATOM   6936 C CB  . SER B 2 470 ? 134.558 118.969 131.703 1.00 56.88  ?  452 SER B CB  1 
ATOM   6937 O OG  . SER B 2 470 ? 133.161 118.786 131.580 1.00 56.88  ?  452 SER B OG  1 
ATOM   6938 N N   . GLY B 2 471 ? 135.616 118.784 128.269 1.00 56.91  ?  453 GLY B N   1 
ATOM   6939 C CA  . GLY B 2 471 ? 135.092 119.075 126.951 1.00 56.91  ?  453 GLY B CA  1 
ATOM   6940 C C   . GLY B 2 471 ? 135.368 117.981 125.944 1.00 56.91  ?  453 GLY B C   1 
ATOM   6941 O O   . GLY B 2 471 ? 135.009 118.103 124.771 1.00 56.91  ?  453 GLY B O   1 
ATOM   6942 N N   . LEU B 2 472 ? 136.005 116.905 126.401 1.00 58.01  ?  454 LEU B N   1 
ATOM   6943 C CA  . LEU B 2 472 ? 136.346 115.801 125.510 1.00 58.01  ?  454 LEU B CA  1 
ATOM   6944 C C   . LEU B 2 472 ? 135.165 115.024 124.917 1.00 58.01  ?  454 LEU B C   1 
ATOM   6945 O O   . LEU B 2 472 ? 135.358 114.439 123.837 1.00 58.01  ?  454 LEU B O   1 
ATOM   6946 C CB  . LEU B 2 472 ? 137.299 114.838 126.235 1.00 58.01  ?  454 LEU B CB  1 
ATOM   6947 C CG  . LEU B 2 472 ? 138.632 115.428 126.693 1.00 58.01  ?  454 LEU B CG  1 
ATOM   6948 C CD1 . LEU B 2 472 ? 139.575 114.331 127.148 1.00 58.01  ?  454 LEU B CD1 1 
ATOM   6949 C CD2 . LEU B 2 472 ? 139.266 116.264 125.596 1.00 58.01  ?  454 LEU B CD2 1 
ATOM   6950 N N   . PRO B 2 473 ? 133.976 114.926 125.534 1.00 60.96  ?  455 PRO B N   1 
ATOM   6951 C CA  . PRO B 2 473 ? 132.819 114.439 124.763 1.00 60.96  ?  455 PRO B CA  1 
ATOM   6952 C C   . PRO B 2 473 ? 132.437 115.308 123.575 1.00 60.96  ?  455 PRO B C   1 
ATOM   6953 O O   . PRO B 2 473 ? 131.833 114.792 122.629 1.00 60.96  ?  455 PRO B O   1 
ATOM   6954 C CB  . PRO B 2 473 ? 131.701 114.405 125.807 1.00 60.96  ?  455 PRO B CB  1 
ATOM   6955 C CG  . PRO B 2 473 ? 132.394 114.040 127.028 1.00 60.96  ?  455 PRO B CG  1 
ATOM   6956 C CD  . PRO B 2 473 ? 133.719 114.746 126.980 1.00 60.96  ?  455 PRO B CD  1 
ATOM   6957 N N   . PHE B 2 474 ? 132.761 116.599 123.580 1.00 61.91  ?  456 PHE B N   1 
ATOM   6958 C CA  . PHE B 2 474 ? 132.482 117.435 122.420 1.00 61.91  ?  456 PHE B CA  1 
ATOM   6959 C C   . PHE B 2 474 ? 133.522 117.282 121.325 1.00 61.91  ?  456 PHE B C   1 
ATOM   6960 O O   . PHE B 2 474 ? 133.205 117.484 120.149 1.00 61.91  ?  456 PHE B O   1 
ATOM   6961 C CB  . PHE B 2 474 ? 132.400 118.906 122.829 1.00 61.91  ?  456 PHE B CB  1 
ATOM   6962 C CG  . PHE B 2 474 ? 131.129 119.267 123.524 1.00 61.91  ?  456 PHE B CG  1 
ATOM   6963 C CD1 . PHE B 2 474 ? 129.976 119.508 122.801 1.00 61.91  ?  456 PHE B CD1 1 
ATOM   6964 C CD2 . PHE B 2 474 ? 131.087 119.367 124.903 1.00 61.91  ?  456 PHE B CD2 1 
ATOM   6965 C CE1 . PHE B 2 474 ? 128.802 119.842 123.440 1.00 61.91  ?  456 PHE B CE1 1 
ATOM   6966 C CE2 . PHE B 2 474 ? 129.915 119.698 125.549 1.00 61.91  ?  456 PHE B CE2 1 
ATOM   6967 C CZ  . PHE B 2 474 ? 128.772 119.937 124.817 1.00 61.91  ?  456 PHE B CZ  1 
ATOM   6968 N N   . TYR B 2 475 ? 134.756 116.929 121.679 1.00 58.61  ?  457 TYR B N   1 
ATOM   6969 C CA  . TYR B 2 475 ? 135.806 116.846 120.673 1.00 58.61  ?  457 TYR B CA  1 
ATOM   6970 C C   . TYR B 2 475 ? 135.699 115.571 119.847 1.00 58.61  ?  457 TYR B C   1 
ATOM   6971 O O   . TYR B 2 475 ? 135.875 115.610 118.627 1.00 58.61  ?  457 TYR B O   1 
ATOM   6972 C CB  . TYR B 2 475 ? 137.180 116.938 121.333 1.00 58.61  ?  457 TYR B CB  1 
ATOM   6973 C CG  . TYR B 2 475 ? 138.314 116.963 120.340 1.00 58.61  ?  457 TYR B CG  1 
ATOM   6974 C CD1 . TYR B 2 475 ? 138.560 118.089 119.570 1.00 58.61  ?  457 TYR B CD1 1 
ATOM   6975 C CD2 . TYR B 2 475 ? 139.132 115.856 120.163 1.00 58.61  ?  457 TYR B CD2 1 
ATOM   6976 C CE1 . TYR B 2 475 ? 139.592 118.115 118.657 1.00 58.61  ?  457 TYR B CE1 1 
ATOM   6977 C CE2 . TYR B 2 475 ? 140.164 115.873 119.251 1.00 58.61  ?  457 TYR B CE2 1 
ATOM   6978 C CZ  . TYR B 2 475 ? 140.388 117.004 118.502 1.00 58.61  ?  457 TYR B CZ  1 
ATOM   6979 O OH  . TYR B 2 475 ? 141.416 117.025 117.593 1.00 58.61  ?  457 TYR B OH  1 
ATOM   6980 N N   . PHE B 2 476 ? 135.406 114.440 120.481 1.00 60.52  ?  458 PHE B N   1 
ATOM   6981 C CA  . PHE B 2 476 ? 135.414 113.166 119.775 1.00 60.52  ?  458 PHE B CA  1 
ATOM   6982 C C   . PHE B 2 476 ? 134.085 112.824 119.122 1.00 60.52  ?  458 PHE B C   1 
ATOM   6983 O O   . PHE B 2 476 ? 134.054 111.957 118.243 1.00 60.52  ?  458 PHE B O   1 
ATOM   6984 C CB  . PHE B 2 476 ? 135.807 112.035 120.727 1.00 60.52  ?  458 PHE B CB  1 
ATOM   6985 C CG  . PHE B 2 476 ? 137.234 112.092 121.171 1.00 60.52  ?  458 PHE B CG  1 
ATOM   6986 C CD1 . PHE B 2 476 ? 138.260 111.906 120.265 1.00 60.52  ?  458 PHE B CD1 1 
ATOM   6987 C CD2 . PHE B 2 476 ? 137.549 112.339 122.494 1.00 60.52  ?  458 PHE B CD2 1 
ATOM   6988 C CE1 . PHE B 2 476 ? 139.576 111.960 120.670 1.00 60.52  ?  458 PHE B CE1 1 
ATOM   6989 C CE2 . PHE B 2 476 ? 138.863 112.396 122.905 1.00 60.52  ?  458 PHE B CE2 1 
ATOM   6990 C CZ  . PHE B 2 476 ? 139.877 112.205 121.991 1.00 60.52  ?  458 PHE B CZ  1 
ATOM   6991 N N   . LEU B 2 477 ? 132.994 113.475 119.515 1.00 63.84  ?  459 LEU B N   1 
ATOM   6992 C CA  . LEU B 2 477 ? 131.685 113.130 118.982 1.00 63.84  ?  459 LEU B CA  1 
ATOM   6993 C C   . LEU B 2 477 ? 131.114 114.171 118.030 1.00 63.84  ?  459 LEU B C   1 
ATOM   6994 O O   . LEU B 2 477 ? 130.121 113.883 117.354 1.00 63.84  ?  459 LEU B O   1 
ATOM   6995 C CB  . LEU B 2 477 ? 130.694 112.900 120.128 1.00 63.84  ?  459 LEU B CB  1 
ATOM   6996 C CG  . LEU B 2 477 ? 131.138 111.867 121.164 1.00 63.84  ?  459 LEU B CG  1 
ATOM   6997 C CD1 . LEU B 2 477 ? 130.186 111.843 122.344 1.00 63.84  ?  459 LEU B CD1 1 
ATOM   6998 C CD2 . LEU B 2 477 ? 131.246 110.493 120.538 1.00 63.84  ?  459 LEU B CD2 1 
ATOM   6999 N N   . ILE B 2 478 ? 131.694 115.368 117.961 1.00 65.12  ?  460 ILE B N   1 
ATOM   7000 C CA  . ILE B 2 478 ? 131.190 116.407 117.067 1.00 65.12  ?  460 ILE B CA  1 
ATOM   7001 C C   . ILE B 2 478 ? 132.311 116.929 116.176 1.00 65.12  ?  460 ILE B C   1 
ATOM   7002 O O   . ILE B 2 478 ? 132.178 116.969 114.948 1.00 65.12  ?  460 ILE B O   1 
ATOM   7003 C CB  . ILE B 2 478 ? 130.532 117.562 117.850 1.00 65.12  ?  460 ILE B CB  1 
ATOM   7004 C CG1 . ILE B 2 478 ? 129.220 117.126 118.505 1.00 65.12  ?  460 ILE B CG1 1 
ATOM   7005 C CG2 . ILE B 2 478 ? 130.272 118.750 116.946 1.00 65.12  ?  460 ILE B CG2 1 
ATOM   7006 C CD1 . ILE B 2 478 ? 129.344 116.685 119.944 1.00 65.12  ?  460 ILE B CD1 1 
ATOM   7007 N N   . ILE B 2 479 ? 133.424 117.331 116.786 1.00 63.00  ?  461 ILE B N   1 
ATOM   7008 C CA  . ILE B 2 479 ? 134.477 118.022 116.050 1.00 63.00  ?  461 ILE B CA  1 
ATOM   7009 C C   . ILE B 2 479 ? 135.314 117.044 115.237 1.00 63.00  ?  461 ILE B C   1 
ATOM   7010 O O   . ILE B 2 479 ? 135.631 117.306 114.071 1.00 63.00  ?  461 ILE B O   1 
ATOM   7011 C CB  . ILE B 2 479 ? 135.328 118.843 117.034 1.00 63.00  ?  461 ILE B CB  1 
ATOM   7012 C CG1 . ILE B 2 479 ? 134.500 120.001 117.576 1.00 63.00  ?  461 ILE B CG1 1 
ATOM   7013 C CG2 . ILE B 2 479 ? 136.600 119.359 116.388 1.00 63.00  ?  461 ILE B CG2 1 
ATOM   7014 C CD1 . ILE B 2 479 ? 135.133 120.698 118.721 1.00 63.00  ?  461 ILE B CD1 1 
ATOM   7015 N N   . ARG B 2 480 ? 135.675 115.903 115.831 1.00 68.76  ?  462 ARG B N   1 
ATOM   7016 C CA  . ARG B 2 480 ? 136.510 114.928 115.138 1.00 68.76  ?  462 ARG B CA  1 
ATOM   7017 C C   . ARG B 2 480 ? 135.772 114.268 113.981 1.00 68.76  ?  462 ARG B C   1 
ATOM   7018 O O   . ARG B 2 480 ? 136.371 114.025 112.928 1.00 68.76  ?  462 ARG B O   1 
ATOM   7019 C CB  . ARG B 2 480 ? 136.996 113.864 116.119 1.00 68.76  ?  462 ARG B CB  1 
ATOM   7020 C CG  . ARG B 2 480 ? 138.066 112.954 115.570 1.00 68.76  ?  462 ARG B CG  1 
ATOM   7021 C CD  . ARG B 2 480 ? 139.443 113.579 115.690 1.00 68.76  ?  462 ARG B CD  1 
ATOM   7022 N NE  . ARG B 2 480 ? 140.437 112.842 114.915 1.00 68.76  ?  462 ARG B NE  1 
ATOM   7023 C CZ  . ARG B 2 480 ? 141.049 111.737 115.331 1.00 68.76  ?  462 ARG B CZ  1 
ATOM   7024 N NH1 . ARG B 2 480 ? 140.776 111.225 116.523 1.00 68.76  1  462 ARG B NH1 1 
ATOM   7025 N NH2 . ARG B 2 480 ? 141.938 111.142 114.549 1.00 68.76  ?  462 ARG B NH2 1 
ATOM   7026 N N   . VAL B 2 481 ? 134.489 113.980 114.150 1.00 72.01  ?  463 VAL B N   1 
ATOM   7027 C CA  . VAL B 2 481 ? 133.696 113.433 113.045 1.00 72.01  ?  463 VAL B CA  1 
ATOM   7028 C C   . VAL B 2 481 ? 133.451 114.533 112.013 1.00 72.01  ?  463 VAL B C   1 
ATOM   7029 O O   . VAL B 2 481 ? 133.221 115.696 112.392 1.00 72.01  ?  463 VAL B O   1 
ATOM   7030 C CB  . VAL B 2 481 ? 132.384 112.813 113.580 1.00 72.01  ?  463 VAL B CB  1 
ATOM   7031 C CG1 . VAL B 2 481 ? 131.502 113.813 114.297 1.00 72.01  ?  463 VAL B CG1 1 
ATOM   7032 C CG2 . VAL B 2 481 ? 131.591 112.130 112.476 1.00 72.01  ?  463 VAL B CG2 1 
ATOM   7033 N N   . PRO B 2 482 ? 133.594 114.260 110.720 1.00 79.08  ?  464 PRO B N   1 
ATOM   7034 C CA  . PRO B 2 482 ? 133.357 115.299 109.716 1.00 79.08  ?  464 PRO B CA  1 
ATOM   7035 C C   . PRO B 2 482 ? 131.869 115.553 109.521 1.00 79.08  ?  464 PRO B C   1 
ATOM   7036 O O   . PRO B 2 482 ? 131.011 114.861 110.067 1.00 79.08  ?  464 PRO B O   1 
ATOM   7037 C CB  . PRO B 2 482 ? 133.987 114.716 108.448 1.00 79.08  ?  464 PRO B CB  1 
ATOM   7038 C CG  . PRO B 2 482 ? 133.948 113.249 108.661 1.00 79.08  ?  464 PRO B CG  1 
ATOM   7039 C CD  . PRO B 2 482 ? 134.206 113.061 110.120 1.00 79.08  ?  464 PRO B CD  1 
ATOM   7040 N N   . GLU B 2 483 ? 131.572 116.565 108.709 1.00 86.06  ?  465 GLU B N   1 
ATOM   7041 C CA  . GLU B 2 483 ? 130.193 116.796 108.316 1.00 86.06  ?  465 GLU B CA  1 
ATOM   7042 C C   . GLU B 2 483 ? 129.763 115.757 107.281 1.00 86.06  ?  465 GLU B C   1 
ATOM   7043 O O   . GLU B 2 483 ? 130.532 114.879 106.891 1.00 86.06  ?  465 GLU B O   1 
ATOM   7044 C CB  . GLU B 2 483 ? 130.003 118.223 107.806 1.00 86.06  ?  465 GLU B CB  1 
ATOM   7045 C CG  . GLU B 2 483 ? 130.674 119.264 108.686 1.00 86.06  ?  465 GLU B CG  1 
ATOM   7046 C CD  . GLU B 2 483 ? 130.660 120.655 108.084 1.00 86.06  ?  465 GLU B CD  1 
ATOM   7047 O OE1 . GLU B 2 483 ? 129.717 120.967 107.325 1.00 86.06  ?  465 GLU B OE1 1 
ATOM   7048 O OE2 . GLU B 2 483 ? 131.584 121.442 108.379 1.00 86.06  -1 465 GLU B OE2 1 
ATOM   7049 N N   . HIS B 2 484 ? 128.481 115.834 106.901 1.00 87.63  ?  466 HIS B N   1 
ATOM   7050 C CA  . HIS B 2 484 ? 127.682 114.796 106.215 1.00 87.63  ?  466 HIS B CA  1 
ATOM   7051 C C   . HIS B 2 484 ? 127.776 113.417 106.891 1.00 87.63  ?  466 HIS B C   1 
ATOM   7052 O O   . HIS B 2 484 ? 127.530 112.388 106.255 1.00 87.63  ?  466 HIS B O   1 
ATOM   7053 C CB  . HIS B 2 484 ? 127.978 114.704 104.699 1.00 87.63  ?  466 HIS B CB  1 
ATOM   7054 C CG  . HIS B 2 484 ? 129.282 114.060 104.329 1.00 87.63  ?  466 HIS B CG  1 
ATOM   7055 N ND1 . HIS B 2 484 ? 129.480 112.696 104.360 1.00 87.63  ?  466 HIS B ND1 1 
ATOM   7056 C CD2 . HIS B 2 484 ? 130.437 114.594 103.867 1.00 87.63  ?  466 HIS B CD2 1 
ATOM   7057 C CE1 . HIS B 2 484 ? 130.712 112.421 103.972 1.00 87.63  ?  466 HIS B CE1 1 
ATOM   7058 N NE2 . HIS B 2 484 ? 131.314 113.556 103.668 1.00 87.63  ?  466 HIS B NE2 1 
ATOM   7059 N N   . LYS B 2 485 ? 128.102 113.388 108.184 1.00 83.00  ?  467 LYS B N   1 
ATOM   7060 C CA  . LYS B 2 485 ? 127.990 112.217 109.040 1.00 83.00  ?  467 LYS B CA  1 
ATOM   7061 C C   . LYS B 2 485 ? 127.433 112.571 110.404 1.00 83.00  ?  467 LYS B C   1 
ATOM   7062 O O   . LYS B 2 485 ? 127.038 111.666 111.143 1.00 83.00  ?  467 LYS B O   1 
ATOM   7063 C CB  . LYS B 2 485 ? 129.351 111.529 109.216 1.00 83.00  ?  467 LYS B CB  1 
ATOM   7064 C CG  . LYS B 2 485 ? 129.803 110.721 108.012 1.00 83.00  ?  467 LYS B CG  1 
ATOM   7065 C CD  . LYS B 2 485 ? 130.999 109.850 108.345 1.00 83.00  ?  467 LYS B CD  1 
ATOM   7066 C CE  . LYS B 2 485 ? 130.655 108.831 109.417 1.00 83.00  ?  467 LYS B CE  1 
ATOM   7067 N NZ  . LYS B 2 485 ? 129.477 108.002 109.038 1.00 83.00  1  467 LYS B NZ  1 
ATOM   7068 N N   . ARG B 2 486 ? 127.393 113.853 110.760 1.00 78.72  ?  468 ARG B N   1 
ATOM   7069 C CA  . ARG B 2 486 ? 126.737 114.317 111.963 1.00 78.72  ?  468 ARG B CA  1 
ATOM   7070 C C   . ARG B 2 486 ? 125.222 114.192 111.795 1.00 78.72  ?  468 ARG B C   1 
ATOM   7071 O O   . ARG B 2 486 ? 124.729 114.098 110.669 1.00 78.72  ?  468 ARG B O   1 
ATOM   7072 C CB  . ARG B 2 486 ? 127.149 115.763 112.238 1.00 78.72  ?  468 ARG B CB  1 
ATOM   7073 C CG  . ARG B 2 486 ? 128.650 115.971 112.221 1.00 78.72  ?  468 ARG B CG  1 
ATOM   7074 C CD  . ARG B 2 486 ? 129.040 117.389 112.574 1.00 78.72  ?  468 ARG B CD  1 
ATOM   7075 N NE  . ARG B 2 486 ? 130.447 117.637 112.281 1.00 78.72  ?  468 ARG B NE  1 
ATOM   7076 C CZ  . ARG B 2 486 ? 131.062 118.796 112.478 1.00 78.72  ?  468 ARG B CZ  1 
ATOM   7077 N NH1 . ARG B 2 486 ? 132.344 118.926 112.179 1.00 78.72  1  468 ARG B NH1 1 
ATOM   7078 N NH2 . ARG B 2 486 ? 130.397 119.825 112.976 1.00 78.72  ?  468 ARG B NH2 1 
ATOM   7079 N N   . PRO B 2 487 ? 124.467 114.144 112.900 1.00 83.84  ?  469 PRO B N   1 
ATOM   7080 C CA  . PRO B 2 487 ? 123.004 114.059 112.785 1.00 83.84  ?  469 PRO B CA  1 
ATOM   7081 C C   . PRO B 2 487 ? 122.394 115.284 112.119 1.00 83.84  ?  469 PRO B C   1 
ATOM   7082 O O   . PRO B 2 487 ? 122.745 116.424 112.428 1.00 83.84  ?  469 PRO B O   1 
ATOM   7083 C CB  . PRO B 2 487 ? 122.547 113.932 114.240 1.00 83.84  ?  469 PRO B CB  1 
ATOM   7084 C CG  . PRO B 2 487 ? 123.681 113.298 114.924 1.00 83.84  ?  469 PRO B CG  1 
ATOM   7085 C CD  . PRO B 2 487 ? 124.909 113.860 114.279 1.00 83.84  ?  469 PRO B CD  1 
ATOM   7086 N N   . LEU B 2 488 ? 121.471 115.025 111.186 1.00 85.13  ?  470 LEU B N   1 
ATOM   7087 C CA  . LEU B 2 488 ? 120.895 116.085 110.364 1.00 85.13  ?  470 LEU B CA  1 
ATOM   7088 C C   . LEU B 2 488 ? 120.007 117.020 111.171 1.00 85.13  ?  470 LEU B C   1 
ATOM   7089 O O   . LEU B 2 488 ? 119.948 118.221 110.876 1.00 85.13  ?  470 LEU B O   1 
ATOM   7090 C CB  . LEU B 2 488 ? 120.097 115.481 109.207 1.00 85.13  ?  470 LEU B CB  1 
ATOM   7091 C CG  . LEU B 2 488 ? 120.779 115.232 107.855 1.00 85.13  ?  470 LEU B CG  1 
ATOM   7092 C CD1 . LEU B 2 488 ? 121.264 116.538 107.252 1.00 85.13  ?  470 LEU B CD1 1 
ATOM   7093 C CD2 . LEU B 2 488 ? 121.917 114.225 107.946 1.00 85.13  ?  470 LEU B CD2 1 
ATOM   7094 N N   . TYR B 2 489 ? 119.317 116.496 112.189 1.00 86.27  ?  471 TYR B N   1 
ATOM   7095 C CA  . TYR B 2 489 ? 118.432 117.329 112.993 1.00 86.27  ?  471 TYR B CA  1 
ATOM   7096 C C   . TYR B 2 489 ? 119.202 118.305 113.870 1.00 86.27  ?  471 TYR B C   1 
ATOM   7097 O O   . TYR B 2 489 ? 118.643 119.329 114.271 1.00 86.27  ?  471 TYR B O   1 
ATOM   7098 C CB  . TYR B 2 489 ? 117.504 116.456 113.845 1.00 86.27  ?  471 TYR B CB  1 
ATOM   7099 C CG  . TYR B 2 489 ? 118.140 115.823 115.067 1.00 86.27  ?  471 TYR B CG  1 
ATOM   7100 C CD1 . TYR B 2 489 ? 118.915 114.675 114.956 1.00 86.27  ?  471 TYR B CD1 1 
ATOM   7101 C CD2 . TYR B 2 489 ? 117.935 116.354 116.338 1.00 86.27  ?  471 TYR B CD2 1 
ATOM   7102 C CE1 . TYR B 2 489 ? 119.486 114.086 116.074 1.00 86.27  ?  471 TYR B CE1 1 
ATOM   7103 C CE2 . TYR B 2 489 ? 118.507 115.774 117.458 1.00 86.27  ?  471 TYR B CE2 1 
ATOM   7104 C CZ  . TYR B 2 489 ? 119.280 114.641 117.318 1.00 86.27  ?  471 TYR B CZ  1 
ATOM   7105 O OH  . TYR B 2 489 ? 119.848 114.059 118.426 1.00 86.27  ?  471 TYR B OH  1 
ATOM   7106 N N   . LEU B 2 490 ? 120.465 118.014 114.173 1.00 81.80  ?  472 LEU B N   1 
ATOM   7107 C CA  . LEU B 2 490 ? 121.307 118.997 114.841 1.00 81.80  ?  472 LEU B CA  1 
ATOM   7108 C C   . LEU B 2 490 ? 121.788 120.061 113.864 1.00 81.80  ?  472 LEU B C   1 
ATOM   7109 O O   . LEU B 2 490 ? 121.822 121.253 114.202 1.00 81.80  ?  472 LEU B O   1 
ATOM   7110 C CB  . LEU B 2 490 ? 122.492 118.297 115.501 1.00 81.80  ?  472 LEU B CB  1 
ATOM   7111 C CG  . LEU B 2 490 ? 123.453 119.165 116.309 1.00 81.80  ?  472 LEU B CG  1 
ATOM   7112 C CD1 . LEU B 2 490 ? 122.832 119.552 117.636 1.00 81.80  ?  472 LEU B CD1 1 
ATOM   7113 C CD2 . LEU B 2 490 ? 124.764 118.431 116.516 1.00 81.80  ?  472 LEU B CD2 1 
ATOM   7114 N N   . ARG B 2 491 ? 122.134 119.645 112.641 1.00 82.21  ?  473 ARG B N   1 
ATOM   7115 C CA  . ARG B 2 491 ? 122.700 120.564 111.658 1.00 82.21  ?  473 ARG B CA  1 
ATOM   7116 C C   . ARG B 2 491 ? 121.671 121.575 111.172 1.00 82.21  ?  473 ARG B C   1 
ATOM   7117 O O   . ARG B 2 491 ? 121.996 122.757 111.009 1.00 82.21  ?  473 ARG B O   1 
ATOM   7118 C CB  . ARG B 2 491 ? 123.275 119.781 110.480 1.00 82.21  ?  473 ARG B CB  1 
ATOM   7119 C CG  . ARG B 2 491 ? 124.398 118.849 110.862 1.00 82.21  ?  473 ARG B CG  1 
ATOM   7120 C CD  . ARG B 2 491 ? 125.409 118.711 109.746 1.00 82.21  ?  473 ARG B CD  1 
ATOM   7121 N NE  . ARG B 2 491 ? 124.939 117.834 108.680 1.00 82.21  ?  473 ARG B NE  1 
ATOM   7122 C CZ  . ARG B 2 491 ? 125.004 118.133 107.389 1.00 82.21  ?  473 ARG B CZ  1 
ATOM   7123 N NH1 . ARG B 2 491 ? 125.521 119.289 107.000 1.00 82.21  1  473 ARG B NH1 1 
ATOM   7124 N NH2 . ARG B 2 491 ? 124.556 117.275 106.485 1.00 82.21  ?  473 ARG B NH2 1 
ATOM   7125 N N   . ARG B 2 492 ? 120.436 121.122 110.986 1.00 82.09  ?  474 ARG B N   1 
ATOM   7126 C CA  . ARG B 2 492 ? 119.348 121.985 110.545 1.00 82.09  ?  474 ARG B CA  1 
ATOM   7127 C C   . ARG B 2 492 ? 118.996 123.028 111.605 1.00 82.09  ?  474 ARG B C   1 
ATOM   7128 O O   . ARG B 2 492 ? 118.693 124.172 111.285 1.00 82.09  ?  474 ARG B O   1 
ATOM   7129 C CB  . ARG B 2 492 ? 118.117 121.147 110.210 1.00 82.09  ?  474 ARG B CB  1 
ATOM   7130 C CG  . ARG B 2 492 ? 117.628 121.311 108.782 1.00 82.09  ?  474 ARG B CG  1 
ATOM   7131 C CD  . ARG B 2 492 ? 116.115 121.204 108.710 1.00 82.09  ?  474 ARG B CD  1 
ATOM   7132 N NE  . ARG B 2 492 ? 115.602 120.178 109.612 1.00 82.09  ?  474 ARG B NE  1 
ATOM   7133 C CZ  . ARG B 2 492 ? 115.713 118.872 109.398 1.00 82.09  ?  474 ARG B CZ  1 
ATOM   7134 N NH1 . ARG B 2 492 ? 115.216 118.010 110.273 1.00 82.09  1  474 ARG B NH1 1 
ATOM   7135 N NH2 . ARG B 2 492 ? 116.320 118.428 108.306 1.00 82.09  ?  474 ARG B NH2 1 
ATOM   7136 N N   . ILE B 2 493 ? 119.038 122.621 112.867 1.00 76.14  ?  475 ILE B N   1 
ATOM   7137 C CA  . ILE B 2 493 ? 118.744 123.504 113.993 1.00 76.14  ?  475 ILE B CA  1 
ATOM   7138 C C   . ILE B 2 493 ? 119.836 124.557 114.148 1.00 76.14  ?  475 ILE B C   1 
ATOM   7139 O O   . ILE B 2 493 ? 119.546 125.753 114.314 1.00 76.14  ?  475 ILE B O   1 
ATOM   7140 C CB  . ILE B 2 493 ? 118.554 122.669 115.275 1.00 76.14  ?  475 ILE B CB  1 
ATOM   7141 C CG1 . ILE B 2 493 ? 117.147 122.075 115.316 1.00 76.14  ?  475 ILE B CG1 1 
ATOM   7142 C CG2 . ILE B 2 493 ? 118.805 123.487 116.531 1.00 76.14  ?  475 ILE B CG2 1 
ATOM   7143 C CD1 . ILE B 2 493 ? 116.910 121.164 116.496 1.00 76.14  ?  475 ILE B CD1 1 
ATOM   7144 N N   . VAL B 2 494 ? 121.104 124.138 114.059 1.00 70.02  ?  476 VAL B N   1 
ATOM   7145 C CA  . VAL B 2 494 ? 122.217 125.077 114.176 1.00 70.02  ?  476 VAL B CA  1 
ATOM   7146 C C   . VAL B 2 494 ? 122.242 126.036 112.988 1.00 70.02  ?  476 VAL B C   1 
ATOM   7147 O O   . VAL B 2 494 ? 122.512 127.233 113.150 1.00 70.02  ?  476 VAL B O   1 
ATOM   7148 C CB  . VAL B 2 494 ? 123.538 124.300 114.344 1.00 70.02  ?  476 VAL B CB  1 
ATOM   7149 C CG1 . VAL B 2 494 ? 124.752 125.196 114.205 1.00 70.02  ?  476 VAL B CG1 1 
ATOM   7150 C CG2 . VAL B 2 494 ? 123.564 123.635 115.701 1.00 70.02  ?  476 VAL B CG2 1 
ATOM   7151 N N   . GLY B 2 495 ? 121.875 125.553 111.797 1.00 68.01  ?  477 GLY B N   1 
ATOM   7152 C CA  . GLY B 2 495 ? 121.815 126.430 110.638 1.00 68.01  ?  477 GLY B CA  1 
ATOM   7153 C C   . GLY B 2 495 ? 120.707 127.463 110.724 1.00 68.01  ?  477 GLY B C   1 
ATOM   7154 O O   . GLY B 2 495 ? 120.907 128.626 110.362 1.00 68.01  ?  477 GLY B O   1 
ATOM   7155 N N   . SER B 2 496 ? 119.533 127.062 111.224 1.00 67.30  ?  478 SER B N   1 
ATOM   7156 C CA  . SER B 2 496 ? 118.432 128.007 111.385 1.00 67.30  ?  478 SER B CA  1 
ATOM   7157 C C   . SER B 2 496 ? 118.740 129.050 112.452 1.00 67.30  ?  478 SER B C   1 
ATOM   7158 O O   . SER B 2 496 ? 118.451 130.241 112.264 1.00 67.30  ?  478 SER B O   1 
ATOM   7159 C CB  . SER B 2 496 ? 117.150 127.254 111.727 1.00 67.30  ?  478 SER B CB  1 
ATOM   7160 O OG  . SER B 2 496 ? 116.854 126.291 110.733 1.00 67.30  ?  478 SER B OG  1 
ATOM   7161 N N   . ALA B 2 497 ? 119.347 128.625 113.566 1.00 63.38  ?  479 ALA B N   1 
ATOM   7162 C CA  . ALA B 2 497 ? 119.725 129.576 114.608 1.00 63.38  ?  479 ALA B CA  1 
ATOM   7163 C C   . ALA B 2 497 ? 120.817 130.525 114.128 1.00 63.38  ?  479 ALA B C   1 
ATOM   7164 O O   . ALA B 2 497 ? 120.794 131.718 114.454 1.00 63.38  ?  479 ALA B O   1 
ATOM   7165 C CB  . ALA B 2 497 ? 120.172 128.828 115.861 1.00 63.38  ?  479 ALA B CB  1 
ATOM   7166 N N   . THR B 2 498 ? 121.756 130.021 113.321 1.00 61.56  ?  480 THR B N   1 
ATOM   7167 C CA  . THR B 2 498 ? 122.801 130.867 112.755 1.00 61.56  ?  480 THR B CA  1 
ATOM   7168 C C   . THR B 2 498 ? 122.226 131.881 111.777 1.00 61.56  ?  480 THR B C   1 
ATOM   7169 O O   . THR B 2 498 ? 122.650 133.039 111.767 1.00 61.56  ?  480 THR B O   1 
ATOM   7170 C CB  . THR B 2 498 ? 123.854 130.003 112.063 1.00 61.56  ?  480 THR B CB  1 
ATOM   7171 O OG1 . THR B 2 498 ? 124.225 128.924 112.927 1.00 61.56  ?  480 THR B OG1 1 
ATOM   7172 C CG2 . THR B 2 498 ? 125.084 130.818 111.727 1.00 61.56  ?  480 THR B CG2 1 
ATOM   7173 N N   . ARG B 2 499 ? 121.240 131.475 110.973 1.00 63.24  ?  481 ARG B N   1 
ATOM   7174 C CA  . ARG B 2 499 ? 120.628 132.399 110.023 1.00 63.24  ?  481 ARG B CA  1 
ATOM   7175 C C   . ARG B 2 499 ? 119.827 133.486 110.733 1.00 63.24  ?  481 ARG B C   1 
ATOM   7176 O O   . ARG B 2 499 ? 119.879 134.660 110.339 1.00 63.24  ?  481 ARG B O   1 
ATOM   7177 C CB  . ARG B 2 499 ? 119.748 131.623 109.046 1.00 63.24  ?  481 ARG B CB  1 
ATOM   7178 C CG  . ARG B 2 499 ? 119.096 132.476 107.979 1.00 63.24  ?  481 ARG B CG  1 
ATOM   7179 C CD  . ARG B 2 499 ? 118.509 131.619 106.876 1.00 63.24  ?  481 ARG B CD  1 
ATOM   7180 N NE  . ARG B 2 499 ? 119.518 131.207 105.906 1.00 63.24  ?  481 ARG B NE  1 
ATOM   7181 C CZ  . ARG B 2 499 ? 120.039 129.988 105.846 1.00 63.24  ?  481 ARG B CZ  1 
ATOM   7182 N NH1 . ARG B 2 499 ? 119.648 129.056 106.702 1.00 63.24  1  481 ARG B NH1 1 
ATOM   7183 N NH2 . ARG B 2 499 ? 120.951 129.701 104.929 1.00 63.24  ?  481 ARG B NH2 1 
ATOM   7184 N N   . TYR B 2 500 ? 119.113 133.128 111.806 1.00 61.87  ?  482 TYR B N   1 
ATOM   7185 C CA  . TYR B 2 500 ? 118.357 134.138 112.544 1.00 61.87  ?  482 TYR B CA  1 
ATOM   7186 C C   . TYR B 2 500 ? 119.276 135.098 113.292 1.00 61.87  ?  482 TYR B C   1 
ATOM   7187 O O   . TYR B 2 500 ? 119.035 136.313 113.300 1.00 61.87  ?  482 TYR B O   1 
ATOM   7188 C CB  . TYR B 2 500 ? 117.378 133.470 113.504 1.00 61.87  ?  482 TYR B CB  1 
ATOM   7189 C CG  . TYR B 2 500 ? 116.098 133.051 112.831 1.00 61.87  ?  482 TYR B CG  1 
ATOM   7190 C CD1 . TYR B 2 500 ? 115.340 133.967 112.113 1.00 61.87  ?  482 TYR B CD1 1 
ATOM   7191 C CD2 . TYR B 2 500 ? 115.656 131.738 112.892 1.00 61.87  ?  482 TYR B CD2 1 
ATOM   7192 C CE1 . TYR B 2 500 ? 114.172 133.588 111.484 1.00 61.87  ?  482 TYR B CE1 1 
ATOM   7193 C CE2 . TYR B 2 500 ? 114.491 131.348 112.266 1.00 61.87  ?  482 TYR B CE2 1 
ATOM   7194 C CZ  . TYR B 2 500 ? 113.753 132.278 111.565 1.00 61.87  ?  482 TYR B CZ  1 
ATOM   7195 O OH  . TYR B 2 500 ? 112.591 131.894 110.942 1.00 61.87  ?  482 TYR B OH  1 
ATOM   7196 N N   . LEU B 2 501 ? 120.346 134.579 113.907 1.00 58.52  ?  483 LEU B N   1 
ATOM   7197 C CA  . LEU B 2 501 ? 121.326 135.446 114.556 1.00 58.52  ?  483 LEU B CA  1 
ATOM   7198 C C   . LEU B 2 501 ? 122.064 136.316 113.548 1.00 58.52  ?  483 LEU B C   1 
ATOM   7199 O O   . LEU B 2 501 ? 122.449 137.444 113.866 1.00 58.52  ?  483 LEU B O   1 
ATOM   7200 C CB  . LEU B 2 501 ? 122.319 134.602 115.351 1.00 58.52  ?  483 LEU B CB  1 
ATOM   7201 C CG  . LEU B 2 501 ? 123.260 135.349 116.291 1.00 58.52  ?  483 LEU B CG  1 
ATOM   7202 C CD1 . LEU B 2 501 ? 122.497 135.873 117.487 1.00 58.52  ?  483 LEU B CD1 1 
ATOM   7203 C CD2 . LEU B 2 501 ? 124.400 134.452 116.726 1.00 58.52  ?  483 LEU B CD2 1 
ATOM   7204 N N   . GLN B 2 502 ? 122.244 135.814 112.329 1.00 58.84  ?  484 GLN B N   1 
ATOM   7205 C CA  . GLN B 2 502 ? 122.886 136.579 111.270 1.00 58.84  ?  484 GLN B CA  1 
ATOM   7206 C C   . GLN B 2 502 ? 122.006 137.732 110.811 1.00 58.84  ?  484 GLN B C   1 
ATOM   7207 O O   . GLN B 2 502 ? 122.502 138.832 110.548 1.00 58.84  ?  484 GLN B O   1 
ATOM   7208 C CB  . GLN B 2 502 ? 123.209 135.628 110.120 1.00 58.84  ?  484 GLN B CB  1 
ATOM   7209 C CG  . GLN B 2 502 ? 123.639 136.251 108.829 1.00 58.84  ?  484 GLN B CG  1 
ATOM   7210 C CD  . GLN B 2 502 ? 124.562 135.341 108.059 1.00 58.84  ?  484 GLN B CD  1 
ATOM   7211 O OE1 . GLN B 2 502 ? 124.701 134.168 108.387 1.00 58.84  ?  484 GLN B OE1 1 
ATOM   7212 N NE2 . GLN B 2 502 ? 125.204 135.875 107.035 1.00 58.84  ?  484 GLN B NE2 1 
ATOM   7213 N N   . VAL B 2 503 ? 120.695 137.502 110.717 1.00 60.14  ?  485 VAL B N   1 
ATOM   7214 C CA  . VAL B 2 503 ? 119.789 138.582 110.333 1.00 60.14  ?  485 VAL B CA  1 
ATOM   7215 C C   . VAL B 2 503 ? 119.649 139.602 111.463 1.00 60.14  ?  485 VAL B C   1 
ATOM   7216 O O   . VAL B 2 503 ? 119.572 140.811 111.208 1.00 60.14  ?  485 VAL B O   1 
ATOM   7217 C CB  . VAL B 2 503 ? 118.436 137.987 109.891 1.00 60.14  ?  485 VAL B CB  1 
ATOM   7218 C CG1 . VAL B 2 503 ? 117.387 139.059 109.669 1.00 60.14  ?  485 VAL B CG1 1 
ATOM   7219 C CG2 . VAL B 2 503 ? 118.616 137.191 108.617 1.00 60.14  ?  485 VAL B CG2 1 
ATOM   7220 N N   . LEU B 2 504 ? 119.672 139.152 112.723 1.00 60.62  ?  486 LEU B N   1 
ATOM   7221 C CA  . LEU B 2 504 ? 119.592 140.090 113.845 1.00 60.62  ?  486 LEU B CA  1 
ATOM   7222 C C   . LEU B 2 504 ? 120.857 140.935 113.978 1.00 60.62  ?  486 LEU B C   1 
ATOM   7223 O O   . LEU B 2 504 ? 120.779 142.159 114.121 1.00 60.62  ?  486 LEU B O   1 
ATOM   7224 C CB  . LEU B 2 504 ? 119.322 139.344 115.150 1.00 60.62  ?  486 LEU B CB  1 
ATOM   7225 C CG  . LEU B 2 504 ? 117.871 138.964 115.426 1.00 60.62  ?  486 LEU B CG  1 
ATOM   7226 C CD1 . LEU B 2 504 ? 117.780 138.093 116.661 1.00 60.62  ?  486 LEU B CD1 1 
ATOM   7227 C CD2 . LEU B 2 504 ? 117.035 140.217 115.589 1.00 60.62  ?  486 LEU B CD2 1 
ATOM   7228 N N   . CYS B 2 505 ? 122.029 140.310 113.940 1.00 59.20  ?  487 CYS B N   1 
ATOM   7229 C CA  . CYS B 2 505 ? 123.270 141.034 114.178 1.00 59.20  ?  487 CYS B CA  1 
ATOM   7230 C C   . CYS B 2 505 ? 123.855 141.682 112.931 1.00 59.20  ?  487 CYS B C   1 
ATOM   7231 O O   . CYS B 2 505 ? 124.839 142.415 113.061 1.00 59.20  ?  487 CYS B O   1 
ATOM   7232 C CB  . CYS B 2 505 ? 124.321 140.103 114.789 1.00 59.20  ?  487 CYS B CB  1 
ATOM   7233 S SG  . CYS B 2 505 ? 123.919 139.489 116.431 1.00 59.20  ?  487 CYS B SG  1 
ATOM   7234 N N   . MET B 2 506 ? 123.281 141.417 111.748 1.00 58.88  ?  488 MET B N   1 
ATOM   7235 C CA  . MET B 2 506 ? 123.729 141.956 110.452 1.00 58.88  ?  488 MET B CA  1 
ATOM   7236 C C   . MET B 2 506 ? 125.190 141.613 110.161 1.00 58.88  ?  488 MET B C   1 
ATOM   7237 O O   . MET B 2 506 ? 125.994 142.472 109.800 1.00 58.88  ?  488 MET B O   1 
ATOM   7238 C CB  . MET B 2 506 ? 123.493 143.467 110.363 1.00 58.88  ?  488 MET B CB  1 
ATOM   7239 C CG  . MET B 2 506 ? 122.058 143.849 110.096 1.00 58.88  ?  488 MET B CG  1 
ATOM   7240 S SD  . MET B 2 506 ? 121.742 144.086 108.342 1.00 58.88  ?  488 MET B SD  1 
ATOM   7241 C CE  . MET B 2 506 ? 122.764 145.515 108.015 1.00 58.88  ?  488 MET B CE  1 
ATOM   7242 N N   . SER B 2 507 ? 125.527 140.333 110.298 1.00 54.97  ?  489 SER B N   1 
ATOM   7243 C CA  . SER B 2 507 ? 126.916 139.897 110.306 1.00 54.97  ?  489 SER B CA  1 
ATOM   7244 C C   . SER B 2 507 ? 127.120 138.728 109.356 1.00 54.97  ?  489 SER B C   1 
ATOM   7245 O O   . SER B 2 507 ? 126.440 137.709 109.476 1.00 54.97  ?  489 SER B O   1 
ATOM   7246 C CB  . SER B 2 507 ? 127.335 139.493 111.720 1.00 54.97  ?  489 SER B CB  1 
ATOM   7247 O OG  . SER B 2 507 ? 127.368 140.612 112.583 1.00 54.97  ?  489 SER B OG  1 
ATOM   7248 N N   . VAL B 2 508 ? 128.068 138.858 108.433 1.00 53.91  ?  490 VAL B N   1 
ATOM   7249 C CA  . VAL B 2 508 ? 128.433 137.761 107.546 1.00 53.91  ?  490 VAL B CA  1 
ATOM   7250 C C   . VAL B 2 508 ? 129.831 137.281 107.901 1.00 53.91  ?  490 VAL B C   1 
ATOM   7251 O O   . VAL B 2 508 ? 130.594 137.953 108.598 1.00 53.91  ?  490 VAL B O   1 
ATOM   7252 C CB  . VAL B 2 508 ? 128.365 138.145 106.053 1.00 53.91  ?  490 VAL B CB  1 
ATOM   7253 C CG1 . VAL B 2 508 ? 126.972 138.558 105.672 1.00 53.91  ?  490 VAL B CG1 1 
ATOM   7254 C CG2 . VAL B 2 508 ? 129.352 139.246 105.742 1.00 53.91  ?  490 VAL B CG2 1 
ATOM   7255 N N   . ALA B 2 509 ? 130.164 136.090 107.413 1.00 58.34  ?  491 ALA B N   1 
ATOM   7256 C CA  . ALA B 2 509 ? 131.516 135.575 107.542 1.00 58.34  ?  491 ALA B CA  1 
ATOM   7257 C C   . ALA B 2 509 ? 132.462 136.342 106.625 1.00 58.34  ?  491 ALA B C   1 
ATOM   7258 O O   . ALA B 2 509 ? 132.042 137.030 105.692 1.00 58.34  ?  491 ALA B O   1 
ATOM   7259 C CB  . ALA B 2 509 ? 131.557 134.086 107.214 1.00 58.34  ?  491 ALA B CB  1 
ATOM   7260 N N   . ALA B 2 510 ? 133.757 136.212 106.900 1.00 64.16  ?  492 ALA B N   1 
ATOM   7261 C CA  . ALA B 2 510 ? 134.757 137.006 106.201 1.00 64.16  ?  492 ALA B CA  1 
ATOM   7262 C C   . ALA B 2 510 ? 134.911 136.553 104.755 1.00 64.16  ?  492 ALA B C   1 
ATOM   7263 O O   . ALA B 2 510 ? 134.841 135.361 104.446 1.00 64.16  ?  492 ALA B O   1 
ATOM   7264 C CB  . ALA B 2 510 ? 136.099 136.920 106.920 1.00 64.16  ?  492 ALA B CB  1 
ATOM   7265 N N   . GLU B 2 511 ? 135.116 137.519 103.868 1.00 73.47  ?  493 GLU B N   1 
ATOM   7266 C CA  . GLU B 2 511 ? 135.249 137.264 102.443 1.00 73.47  ?  493 GLU B CA  1 
ATOM   7267 C C   . GLU B 2 511 ? 136.718 137.195 102.047 1.00 73.47  ?  493 GLU B C   1 
ATOM   7268 O O   . GLU B 2 511 ? 137.623 137.345 102.870 1.00 73.47  ?  493 GLU B O   1 
ATOM   7269 C CB  . GLU B 2 511 ? 134.533 138.348 101.635 1.00 73.47  ?  493 GLU B CB  1 
ATOM   7270 C CG  . GLU B 2 511 ? 133.208 138.783 102.225 1.00 73.47  ?  493 GLU B CG  1 
ATOM   7271 C CD  . GLU B 2 511 ? 132.349 139.529 101.232 1.00 73.47  ?  493 GLU B CD  1 
ATOM   7272 O OE1 . GLU B 2 511 ? 131.401 138.922 100.695 1.00 73.47  ?  493 GLU B OE1 1 
ATOM   7273 O OE2 . GLU B 2 511 ? 132.623 140.722 100.985 1.00 73.47  -1 493 GLU B OE2 1 
HETATM 7274 C C1  . NAG C 3 .   ? 156.761 123.203 186.083 1.00 93.28  ?  1   NAG C C1  1 
HETATM 7275 C C2  . NAG C 3 .   ? 155.562 123.563 186.954 1.00 93.28  ?  1   NAG C C2  1 
HETATM 7276 C C3  . NAG C 3 .   ? 155.567 122.726 188.230 1.00 93.28  ?  1   NAG C C3  1 
HETATM 7277 C C4  . NAG C 3 .   ? 155.656 121.238 187.910 1.00 93.28  ?  1   NAG C C4  1 
HETATM 7278 C C5  . NAG C 3 .   ? 156.842 120.960 186.988 1.00 93.28  ?  1   NAG C C5  1 
HETATM 7279 C C6  . NAG C 3 .   ? 156.869 119.541 186.477 1.00 93.28  ?  1   NAG C C6  1 
HETATM 7280 C C7  . NAG C 3 .   ? 154.535 125.795 187.033 1.00 93.28  ?  1   NAG C C7  1 
HETATM 7281 C C8  . NAG C 3 .   ? 154.722 127.227 187.426 1.00 93.28  ?  1   NAG C C8  1 
HETATM 7282 N N2  . NAG C 3 .   ? 155.568 124.981 187.274 1.00 93.28  ?  1   NAG C N2  1 
HETATM 7283 O O3  . NAG C 3 .   ? 154.383 123.014 188.962 1.00 93.28  ?  1   NAG C O3  1 
HETATM 7284 O O4  . NAG C 3 .   ? 155.815 120.467 189.096 1.00 93.28  ?  1   NAG C O4  1 
HETATM 7285 O O5  . NAG C 3 .   ? 156.763 121.796 185.823 1.00 93.28  ?  1   NAG C O5  1 
HETATM 7286 O O6  . NAG C 3 .   ? 156.059 119.401 185.318 1.00 93.28  ?  1   NAG C O6  1 
HETATM 7287 O O7  . NAG C 3 .   ? 153.497 125.394 186.521 1.00 93.28  ?  1   NAG C O7  1 
HETATM 7288 C C1  . NAG C 3 .   ? 154.576 119.783 189.402 1.00 107.76 ?  2   NAG C C1  1 
HETATM 7289 C C2  . NAG C 3 .   ? 154.844 118.469 190.136 1.00 107.76 ?  2   NAG C C2  1 
HETATM 7290 C C3  . NAG C 3 .   ? 153.523 117.794 190.501 1.00 107.76 ?  2   NAG C C3  1 
HETATM 7291 C C4  . NAG C 3 .   ? 152.622 118.745 191.279 1.00 107.76 ?  2   NAG C C4  1 
HETATM 7292 C C5  . NAG C 3 .   ? 152.446 120.059 190.520 1.00 107.76 ?  2   NAG C C5  1 
HETATM 7293 C C6  . NAG C 3 .   ? 151.682 121.098 191.310 1.00 107.76 ?  2   NAG C C6  1 
HETATM 7294 C C7  . NAG C 3 .   ? 157.004 117.547 189.419 1.00 107.76 ?  2   NAG C C7  1 
HETATM 7295 C C8  . NAG C 3 .   ? 157.695 116.555 188.530 1.00 107.76 ?  2   NAG C C8  1 
HETATM 7296 N N2  . NAG C 3 .   ? 155.669 117.576 189.338 1.00 107.76 ?  2   NAG C N2  1 
HETATM 7297 O O3  . NAG C 3 .   ? 153.792 116.642 191.289 1.00 107.76 ?  2   NAG C O3  1 
HETATM 7298 O O4  . NAG C 3 .   ? 151.343 118.151 191.469 1.00 107.76 ?  2   NAG C O4  1 
HETATM 7299 O O5  . NAG C 3 .   ? 153.728 120.628 190.216 1.00 107.76 ?  2   NAG C O5  1 
HETATM 7300 O O6  . NAG C 3 .   ? 152.468 122.261 191.530 1.00 107.76 ?  2   NAG C O6  1 
HETATM 7301 O O7  . NAG C 3 .   ? 157.628 118.292 190.170 1.00 107.76 ?  2   NAG C O7  1 
HETATM 7302 C C1  . NAG D 3 .   ? 143.609 173.855 183.862 1.00 80.79  ?  1   NAG D C1  1 
HETATM 7303 C C2  . NAG D 3 .   ? 142.898 174.297 182.574 1.00 80.79  ?  1   NAG D C2  1 
HETATM 7304 C C3  . NAG D 3 .   ? 141.431 174.695 182.856 1.00 80.79  ?  1   NAG D C3  1 
HETATM 7305 C C4  . NAG D 3 .   ? 141.181 175.195 184.285 1.00 80.79  ?  1   NAG D C4  1 
HETATM 7306 C C5  . NAG D 3 .   ? 141.922 174.370 185.352 1.00 80.79  ?  1   NAG D C5  1 
HETATM 7307 C C6  . NAG D 3 .   ? 141.000 173.704 186.344 1.00 80.79  ?  1   NAG D C6  1 
HETATM 7308 C C7  . NAG D 3 .   ? 144.121 175.286 180.689 1.00 80.79  ?  1   NAG D C7  1 
HETATM 7309 C C8  . NAG D 3 .   ? 144.805 176.507 180.161 1.00 80.79  ?  1   NAG D C8  1 
HETATM 7310 N N2  . NAG D 3 .   ? 143.606 175.386 181.919 1.00 80.79  ?  1   NAG D N2  1 
HETATM 7311 O O3  . NAG D 3 .   ? 140.588 173.579 182.591 1.00 80.79  ?  1   NAG D O3  1 
HETATM 7312 O O4  . NAG D 3 .   ? 141.358 176.612 184.399 1.00 80.79  ?  1   NAG D O4  1 
HETATM 7313 O O5  . NAG D 3 .   ? 142.681 173.318 184.742 1.00 80.79  ?  1   NAG D O5  1 
HETATM 7314 O O6  . NAG D 3 .   ? 141.402 172.367 186.611 1.00 80.79  ?  1   NAG D O6  1 
HETATM 7315 O O7  . NAG D 3 .   ? 144.042 174.254 180.034 1.00 80.79  ?  1   NAG D O7  1 
HETATM 7316 C C1  . NAG D 3 .   ? 142.620 177.166 184.900 1.00 94.05  ?  2   NAG D C1  1 
HETATM 7317 C C2  . NAG D 3 .   ? 142.963 178.459 184.153 1.00 94.05  ?  2   NAG D C2  1 
HETATM 7318 C C3  . NAG D 3 .   ? 144.303 178.998 184.648 1.00 94.05  ?  2   NAG D C3  1 
HETATM 7319 C C4  . NAG D 3 .   ? 144.291 179.167 186.163 1.00 94.05  ?  2   NAG D C4  1 
HETATM 7320 C C5  . NAG D 3 .   ? 143.839 177.882 186.865 1.00 94.05  ?  2   NAG D C5  1 
HETATM 7321 C C6  . NAG D 3 .   ? 143.629 178.069 188.351 1.00 94.05  ?  2   NAG D C6  1 
HETATM 7322 C C7  . NAG D 3 .   ? 142.401 179.063 181.815 1.00 94.05  ?  2   NAG D C7  1 
HETATM 7323 C C8  . NAG D 3 .   ? 141.647 180.243 182.363 1.00 94.05  ?  2   NAG D C8  1 
HETATM 7324 N N2  . NAG D 3 .   ? 142.993 178.257 182.711 1.00 94.05  ?  2   NAG D N2  1 
HETATM 7325 O O3  . NAG D 3 .   ? 144.565 180.250 184.026 1.00 94.05  ?  2   NAG D O3  1 
HETATM 7326 O O4  . NAG D 3 .   ? 145.598 179.509 186.612 1.00 94.05  ?  2   NAG D O4  1 
HETATM 7327 O O5  . NAG D 3 .   ? 142.585 177.429 186.328 1.00 94.05  ?  2   NAG D O5  1 
HETATM 7328 O O6  . NAG D 3 .   ? 144.495 177.243 189.118 1.00 94.05  ?  2   NAG D O6  1 
HETATM 7329 O O7  . NAG D 3 .   ? 142.463 178.841 180.610 1.00 94.05  ?  2   NAG D O7  1 
HETATM 7330 C C1  . NAG E 3 .   ? 146.975 152.292 202.164 1.00 63.03  ?  1   NAG E C1  1 
HETATM 7331 C C2  . NAG E 3 .   ? 145.849 151.575 202.893 1.00 63.03  ?  1   NAG E C2  1 
HETATM 7332 C C3  . NAG E 3 .   ? 145.704 152.139 204.297 1.00 63.03  ?  1   NAG E C3  1 
HETATM 7333 C C4  . NAG E 3 .   ? 147.014 151.975 205.052 1.00 63.03  ?  1   NAG E C4  1 
HETATM 7334 C C5  . NAG E 3 .   ? 148.169 152.628 204.285 1.00 63.03  ?  1   NAG E C5  1 
HETATM 7335 C C6  . NAG E 3 .   ? 149.516 152.248 204.849 1.00 63.03  ?  1   NAG E C6  1 
HETATM 7336 C C7  . NAG E 3 .   ? 143.832 150.591 201.929 1.00 63.03  ?  1   NAG E C7  1 
HETATM 7337 C C8  . NAG E 3 .   ? 142.549 150.845 201.190 1.00 63.03  ?  1   NAG E C8  1 
HETATM 7338 N N2  . NAG E 3 .   ? 144.590 151.663 202.175 1.00 63.03  ?  1   NAG E N2  1 
HETATM 7339 O O3  . NAG E 3 .   ? 144.674 151.435 204.975 1.00 63.03  ?  1   NAG E O3  1 
HETATM 7340 O O4  . NAG E 3 .   ? 146.894 152.436 206.396 1.00 63.03  ?  1   NAG E O4  1 
HETATM 7341 O O5  . NAG E 3 .   ? 148.191 152.170 202.921 1.00 63.03  ?  1   NAG E O5  1 
HETATM 7342 O O6  . NAG E 3 .   ? 149.873 150.938 204.430 1.00 63.03  ?  1   NAG E O6  1 
HETATM 7343 O O7  . NAG E 3 .   ? 144.170 149.464 202.280 1.00 63.03  ?  1   NAG E O7  1 
HETATM 7344 C C1  . NAG E 3 .   ? 146.753 153.857 206.593 1.00 73.19  ?  2   NAG E C1  1 
HETATM 7345 C C2  . NAG E 3 .   ? 145.659 154.143 207.610 1.00 73.19  ?  2   NAG E C2  1 
HETATM 7346 C C3  . NAG E 3 .   ? 145.556 155.642 207.851 1.00 73.19  ?  2   NAG E C3  1 
HETATM 7347 C C4  . NAG E 3 .   ? 146.904 156.199 208.294 1.00 73.19  ?  2   NAG E C4  1 
HETATM 7348 C C5  . NAG E 3 .   ? 148.001 155.815 207.303 1.00 73.19  ?  2   NAG E C5  1 
HETATM 7349 C C6  . NAG E 3 .   ? 149.382 156.152 207.806 1.00 73.19  ?  2   NAG E C6  1 
HETATM 7350 C C7  . NAG E 3 .   ? 143.755 152.628 207.871 1.00 73.19  ?  2   NAG E C7  1 
HETATM 7351 C C8  . NAG E 3 .   ? 142.436 152.182 207.319 1.00 73.19  ?  2   NAG E C8  1 
HETATM 7352 N N2  . NAG E 3 .   ? 144.377 153.599 207.195 1.00 73.19  ?  2   NAG E N2  1 
HETATM 7353 O O3  . NAG E 3 .   ? 144.574 155.882 208.850 1.00 73.19  ?  2   NAG E O3  1 
HETATM 7354 O O4  . NAG E 3 .   ? 146.844 157.619 208.374 1.00 73.19  ?  2   NAG E O4  1 
HETATM 7355 O O5  . NAG E 3 .   ? 147.997 154.399 207.064 1.00 73.19  ?  2   NAG E O5  1 
HETATM 7356 O O6  . NAG E 3 .   ? 149.868 155.139 208.676 1.00 73.19  ?  2   NAG E O6  1 
HETATM 7357 O O7  . NAG E 3 .   ? 144.237 152.134 208.887 1.00 73.19  ?  2   NAG E O7  1 
HETATM 7358 C C1  . NAG F 3 .   ? 123.219 151.982 187.030 1.00 73.88  ?  1   NAG F C1  1 
HETATM 7359 C C2  . NAG F 3 .   ? 122.977 153.358 187.677 1.00 73.88  ?  1   NAG F C2  1 
HETATM 7360 C C3  . NAG F 3 .   ? 121.965 154.176 186.870 1.00 73.88  ?  1   NAG F C3  1 
HETATM 7361 C C4  . NAG F 3 .   ? 120.747 153.348 186.469 1.00 73.88  ?  1   NAG F C4  1 
HETATM 7362 C C5  . NAG F 3 .   ? 121.156 152.010 185.852 1.00 73.88  ?  1   NAG F C5  1 
HETATM 7363 C C6  . NAG F 3 .   ? 120.616 151.818 184.454 1.00 73.88  ?  1   NAG F C6  1 
HETATM 7364 C C7  . NAG F 3 .   ? 122.775 154.130 189.993 1.00 73.88  ?  1   NAG F C7  1 
HETATM 7365 C C8  . NAG F 3 .   ? 122.244 153.823 191.359 1.00 73.88  ?  1   NAG F C8  1 
HETATM 7366 N N2  . NAG F 3 .   ? 122.531 153.214 189.053 1.00 73.88  ?  1   NAG F N2  1 
HETATM 7367 O O3  . NAG F 3 .   ? 122.609 154.693 185.712 1.00 73.88  ?  1   NAG F O3  1 
HETATM 7368 O O4  . NAG F 3 .   ? 119.896 153.127 187.589 1.00 73.88  ?  1   NAG F O4  1 
HETATM 7369 O O5  . NAG F 3 .   ? 122.585 151.933 185.756 1.00 73.88  ?  1   NAG F O5  1 
HETATM 7370 O O6  . NAG F 3 .   ? 121.458 152.430 183.487 1.00 73.88  ?  1   NAG F O6  1 
HETATM 7371 O O7  . NAG F 3 .   ? 123.397 155.159 189.752 1.00 73.88  ?  1   NAG F O7  1 
HETATM 7372 C C1  . NAG F 3 .   ? 118.809 154.084 187.501 1.00 94.18  ?  2   NAG F C1  1 
HETATM 7373 C C2  . NAG F 3 .   ? 117.457 153.411 187.783 1.00 94.18  ?  2   NAG F C2  1 
HETATM 7374 C C3  . NAG F 3 .   ? 116.333 154.447 187.705 1.00 94.18  ?  2   NAG F C3  1 
HETATM 7375 C C4  . NAG F 3 .   ? 116.621 155.636 188.614 1.00 94.18  ?  2   NAG F C4  1 
HETATM 7376 C C5  . NAG F 3 .   ? 118.008 156.214 188.330 1.00 94.18  ?  2   NAG F C5  1 
HETATM 7377 C C6  . NAG F 3 .   ? 118.404 157.300 189.302 1.00 94.18  ?  2   NAG F C6  1 
HETATM 7378 C C7  . NAG F 3 .   ? 116.505 151.227 187.175 1.00 94.18  ?  2   NAG F C7  1 
HETATM 7379 C C8  . NAG F 3 .   ? 116.358 150.199 186.094 1.00 94.18  ?  2   NAG F C8  1 
HETATM 7380 N N2  . NAG F 3 .   ? 117.211 152.318 186.855 1.00 94.18  ?  2   NAG F N2  1 
HETATM 7381 O O3  . NAG F 3 .   ? 115.090 153.855 188.068 1.00 94.18  ?  2   NAG F O3  1 
HETATM 7382 O O4  . NAG F 3 .   ? 115.644 156.646 188.391 1.00 94.18  ?  2   NAG F O4  1 
HETATM 7383 O O5  . NAG F 3 .   ? 119.006 155.184 188.430 1.00 94.18  ?  2   NAG F O5  1 
HETATM 7384 O O6  . NAG F 3 .   ? 118.591 156.778 190.609 1.00 94.18  ?  2   NAG F O6  1 
HETATM 7385 O O7  . NAG F 3 .   ? 116.012 151.076 188.287 1.00 94.18  ?  2   NAG F O7  1 
HETATM 7386 N N   . ARG G 4 .   ? 148.543 142.415 136.851 1.00 60.58  ?  601 ARG B N   1 
HETATM 7387 C CA  . ARG G 4 .   ? 147.098 142.286 136.984 1.00 60.58  ?  601 ARG B CA  1 
HETATM 7388 C C   . ARG G 4 .   ? 146.578 143.014 138.219 1.00 60.58  ?  601 ARG B C   1 
HETATM 7389 O O   . ARG G 4 .   ? 145.319 143.109 138.350 1.00 60.58  ?  601 ARG B O   1 
HETATM 7390 C CB  . ARG G 4 .   ? 146.699 140.811 137.039 1.00 60.58  ?  601 ARG B CB  1 
HETATM 7391 C CG  . ARG G 4 .   ? 146.706 140.121 135.689 1.00 60.58  ?  601 ARG B CG  1 
HETATM 7392 C CD  . ARG G 4 .   ? 145.517 140.550 134.846 1.00 60.58  ?  601 ARG B CD  1 
HETATM 7393 N NE  . ARG G 4 .   ? 145.480 139.853 133.565 1.00 60.58  ?  601 ARG B NE  1 
HETATM 7394 C CZ  . ARG G 4 .   ? 145.687 138.548 133.419 1.00 60.58  ?  601 ARG B CZ  1 
HETATM 7395 N NH1 . ARG G 4 .   ? 145.635 137.996 132.215 1.00 60.58  1  601 ARG B NH1 1 
HETATM 7396 N NH2 . ARG G 4 .   ? 145.945 137.796 134.479 1.00 60.58  ?  601 ARG B NH2 1 
HETATM 7397 O OXT . ARG G 4 .   ? 147.432 143.478 139.039 1.00 60.58  -1 601 ARG B OXT 1 
HETATM 7398 O O   . HOH H 5 .   ? 150.856 136.700 131.004 1.00 30.00  ?  701 HOH B O   1 
# 
