data_8KEX
# 
_entry.id   8KEX 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8KEX         pdb_00008kex 10.2210/pdb8kex/pdb 
WWPDB D_1300040267 ?            ?                   
EMDB  EMD-37191    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-11-06 
2 'Structure model' 1 1 2024-11-13 
3 'Structure model' 1 2 2024-11-27 
4 'Structure model' 1 3 2024-12-25 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Data collection'     
2 2 'Structure model' 'Database references' 
3 3 'Structure model' 'Data collection'     
4 4 'Structure model' 'Data collection'     
5 4 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation 
2 2 'Structure model' em_admin 
3 3 'Structure model' em_admin 
4 4 'Structure model' citation 
5 4 'Structure model' em_admin 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_ASTM'         
4  2 'Structure model' '_citation.journal_id_CSD'          
5  2 'Structure model' '_citation.journal_id_ISSN'         
6  2 'Structure model' '_citation.pdbx_database_id_PubMed' 
7  2 'Structure model' '_citation.title'                   
8  2 'Structure model' '_em_admin.last_update'             
9  3 'Structure model' '_em_admin.last_update'             
10 4 'Structure model' '_citation.journal_volume'          
11 4 'Structure model' '_citation.page_first'              
12 4 'Structure model' '_citation.page_last'               
13 4 'Structure model' '_em_admin.last_update'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8KEX 
_pdbx_database_status.recvd_initial_deposition_date   2023-08-14 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P, local' 
_pdbx_database_related.db_id          EMD-37191 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              jun_yang96@163.com 
_pdbx_contact_author.name_first         Xiaoguang 
_pdbx_contact_author.name_last          Lei 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0380-8035 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Yang, J.'  1 ? 
'Fan, J.P.' 2 ? 
'Lei, X.G.' 3 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Cell 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1097-4172 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            187 
_citation.language                  ? 
_citation.page_first                7164 
_citation.page_last                 7182.e18 
_citation.title                     
'Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.cell.2024.10.001 
_citation.pdbx_database_id_PubMed   39476841 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Yang, J.' 1  ? 
primary 'Zhao, T.' 2  ? 
primary 'Fan, J.'  3  ? 
primary 'Zou, H.'  4  ? 
primary 'Lan, G.'  5  ? 
primary 'Guo, F.'  6  ? 
primary 'Shi, Y.'  7  ? 
primary 'Ke, H.'   8  ? 
primary 'Yu, H.'   9  ? 
primary 'Yue, Z.'  10 ? 
primary 'Wang, X.' 11 ? 
primary 'Bai, Y.'  12 ? 
primary 'Li, S.'   13 ? 
primary 'Liu, Y.'  14 ? 
primary 'Wang, X.' 15 ? 
primary 'Chen, Y.' 16 ? 
primary 'Li, Y.'   17 ? 
primary 'Lei, X.'  18 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Soluble cytochrome b562,Mas-related G-protein coupled receptor member X4,Green fluorescent protein' 79795.680 1 
? ? ? ? 
2 non-polymer syn 
;(4~{R})-4-[(3~{R},5~{R},8~{R},9~{S},10~{S},12~{S},13~{R},14~{S},17~{R})-10,13-dimethyl-12-oxidanyl-3-phosphonooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{H}-cyclopenta[a]phenanthren-17-yl]pentanoic acid
;
472.552   1 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Cytochrome b-562,Sensory neuron-specific G-protein coupled receptor 5/6' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;DYKDDDDKEFADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVG
QIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLMDPTVPVFGTKLTPINGREETPCYNQTLSFTVLTCIISLVGLTG
NAVVLWLLGYRMRRNAVSIYILNLAAADFLFLSFQIIRLPLRLINISHLIRKILVSVMTFPYFTGLSMLSAISTERCLSV
LWPIWYRCRRPTHLSAVVCVLLWGLSLLFSMLEWRFCDFLFSGADSSWCETSDFIPVAWLIFLCVVLCVSSLVLLVRILC
GSRKMPLTRLYVTILLTVLVFLLCGLPFGILGALIYRMHLNLEVLYCHVYLVCMSLSSLNSSANPIIYFFVGSFRQRQNR
QNLKLVLQRALQDKPEVDKGEGQLPEESLELSGSRLGPLELEVLFQGPSKGEELFTGVVPILVELDGDVNGHKFSVRGEG
EGDATNGKLTLKFICTTGKLPVPWPTLVTTLTYGVQCFSRYPDHMKRHDFFKSAMPEGYVQERTISFKDDGTYKTRAEVK
FEGDTLVNRIELKGIDFKEDGNILGHKLEYNFNSHNVYITADKQKNGIKANFKIRHNVEDGSVQLADHYQQNTPIGDGPV
LLPDNHYLSTQSVLSKDPNEKRDHMVLLEFVTAAGITHGMDEWSHPQFEKGGGSGGGSGGSAWSHPQFEK
;
_entity_poly.pdbx_seq_one_letter_code_can   
;DYKDDDDKEFADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVG
QIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLMDPTVPVFGTKLTPINGREETPCYNQTLSFTVLTCIISLVGLTG
NAVVLWLLGYRMRRNAVSIYILNLAAADFLFLSFQIIRLPLRLINISHLIRKILVSVMTFPYFTGLSMLSAISTERCLSV
LWPIWYRCRRPTHLSAVVCVLLWGLSLLFSMLEWRFCDFLFSGADSSWCETSDFIPVAWLIFLCVVLCVSSLVLLVRILC
GSRKMPLTRLYVTILLTVLVFLLCGLPFGILGALIYRMHLNLEVLYCHVYLVCMSLSSLNSSANPIIYFFVGSFRQRQNR
QNLKLVLQRALQDKPEVDKGEGQLPEESLELSGSRLGPLELEVLFQGPSKGEELFTGVVPILVELDGDVNGHKFSVRGEG
EGDATNGKLTLKFICTTGKLPVPWPTLVTTLTYGVQCFSRYPDHMKRHDFFKSAMPEGYVQERTISFKDDGTYKTRAEVK
FEGDTLVNRIELKGIDFKEDGNILGHKLEYNFNSHNVYITADKQKNGIKANFKIRHNVEDGSVQLADHYQQNTPIGDGPV
LLPDNHYLSTQSVLSKDPNEKRDHMVLLEFVTAAGITHGMDEWSHPQFEKGGGSGGGSGGSAWSHPQFEK
;
_entity_poly.pdbx_strand_id                 E 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        
;(4~{R})-4-[(3~{R},5~{R},8~{R},9~{S},10~{S},12~{S},13~{R},14~{S},17~{R})-10,13-dimethyl-12-oxidanyl-3-phosphonooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{H}-cyclopenta[a]phenanthren-17-yl]pentanoic acid
;
_pdbx_entity_nonpoly.comp_id     JW0 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ASP n 
1 2   TYR n 
1 3   LYS n 
1 4   ASP n 
1 5   ASP n 
1 6   ASP n 
1 7   ASP n 
1 8   LYS n 
1 9   GLU n 
1 10  PHE n 
1 11  ALA n 
1 12  ASP n 
1 13  LEU n 
1 14  GLU n 
1 15  ASP n 
1 16  ASN n 
1 17  TRP n 
1 18  GLU n 
1 19  THR n 
1 20  LEU n 
1 21  ASN n 
1 22  ASP n 
1 23  ASN n 
1 24  LEU n 
1 25  LYS n 
1 26  VAL n 
1 27  ILE n 
1 28  GLU n 
1 29  LYS n 
1 30  ALA n 
1 31  ASP n 
1 32  ASN n 
1 33  ALA n 
1 34  ALA n 
1 35  GLN n 
1 36  VAL n 
1 37  LYS n 
1 38  ASP n 
1 39  ALA n 
1 40  LEU n 
1 41  THR n 
1 42  LYS n 
1 43  MET n 
1 44  ARG n 
1 45  ALA n 
1 46  ALA n 
1 47  ALA n 
1 48  LEU n 
1 49  ASP n 
1 50  ALA n 
1 51  GLN n 
1 52  LYS n 
1 53  ALA n 
1 54  THR n 
1 55  PRO n 
1 56  PRO n 
1 57  LYS n 
1 58  LEU n 
1 59  GLU n 
1 60  ASP n 
1 61  LYS n 
1 62  SER n 
1 63  PRO n 
1 64  ASP n 
1 65  SER n 
1 66  PRO n 
1 67  GLU n 
1 68  MET n 
1 69  LYS n 
1 70  ASP n 
1 71  PHE n 
1 72  ARG n 
1 73  HIS n 
1 74  GLY n 
1 75  PHE n 
1 76  ASP n 
1 77  ILE n 
1 78  LEU n 
1 79  VAL n 
1 80  GLY n 
1 81  GLN n 
1 82  ILE n 
1 83  ASP n 
1 84  ASP n 
1 85  ALA n 
1 86  LEU n 
1 87  LYS n 
1 88  LEU n 
1 89  ALA n 
1 90  ASN n 
1 91  GLU n 
1 92  GLY n 
1 93  LYS n 
1 94  VAL n 
1 95  LYS n 
1 96  GLU n 
1 97  ALA n 
1 98  GLN n 
1 99  ALA n 
1 100 ALA n 
1 101 ALA n 
1 102 GLU n 
1 103 GLN n 
1 104 LEU n 
1 105 LYS n 
1 106 THR n 
1 107 THR n 
1 108 ARG n 
1 109 ASN n 
1 110 ALA n 
1 111 TYR n 
1 112 ILE n 
1 113 GLN n 
1 114 LYS n 
1 115 TYR n 
1 116 LEU n 
1 117 MET n 
1 118 ASP n 
1 119 PRO n 
1 120 THR n 
1 121 VAL n 
1 122 PRO n 
1 123 VAL n 
1 124 PHE n 
1 125 GLY n 
1 126 THR n 
1 127 LYS n 
1 128 LEU n 
1 129 THR n 
1 130 PRO n 
1 131 ILE n 
1 132 ASN n 
1 133 GLY n 
1 134 ARG n 
1 135 GLU n 
1 136 GLU n 
1 137 THR n 
1 138 PRO n 
1 139 CYS n 
1 140 TYR n 
1 141 ASN n 
1 142 GLN n 
1 143 THR n 
1 144 LEU n 
1 145 SER n 
1 146 PHE n 
1 147 THR n 
1 148 VAL n 
1 149 LEU n 
1 150 THR n 
1 151 CYS n 
1 152 ILE n 
1 153 ILE n 
1 154 SER n 
1 155 LEU n 
1 156 VAL n 
1 157 GLY n 
1 158 LEU n 
1 159 THR n 
1 160 GLY n 
1 161 ASN n 
1 162 ALA n 
1 163 VAL n 
1 164 VAL n 
1 165 LEU n 
1 166 TRP n 
1 167 LEU n 
1 168 LEU n 
1 169 GLY n 
1 170 TYR n 
1 171 ARG n 
1 172 MET n 
1 173 ARG n 
1 174 ARG n 
1 175 ASN n 
1 176 ALA n 
1 177 VAL n 
1 178 SER n 
1 179 ILE n 
1 180 TYR n 
1 181 ILE n 
1 182 LEU n 
1 183 ASN n 
1 184 LEU n 
1 185 ALA n 
1 186 ALA n 
1 187 ALA n 
1 188 ASP n 
1 189 PHE n 
1 190 LEU n 
1 191 PHE n 
1 192 LEU n 
1 193 SER n 
1 194 PHE n 
1 195 GLN n 
1 196 ILE n 
1 197 ILE n 
1 198 ARG n 
1 199 LEU n 
1 200 PRO n 
1 201 LEU n 
1 202 ARG n 
1 203 LEU n 
1 204 ILE n 
1 205 ASN n 
1 206 ILE n 
1 207 SER n 
1 208 HIS n 
1 209 LEU n 
1 210 ILE n 
1 211 ARG n 
1 212 LYS n 
1 213 ILE n 
1 214 LEU n 
1 215 VAL n 
1 216 SER n 
1 217 VAL n 
1 218 MET n 
1 219 THR n 
1 220 PHE n 
1 221 PRO n 
1 222 TYR n 
1 223 PHE n 
1 224 THR n 
1 225 GLY n 
1 226 LEU n 
1 227 SER n 
1 228 MET n 
1 229 LEU n 
1 230 SER n 
1 231 ALA n 
1 232 ILE n 
1 233 SER n 
1 234 THR n 
1 235 GLU n 
1 236 ARG n 
1 237 CYS n 
1 238 LEU n 
1 239 SER n 
1 240 VAL n 
1 241 LEU n 
1 242 TRP n 
1 243 PRO n 
1 244 ILE n 
1 245 TRP n 
1 246 TYR n 
1 247 ARG n 
1 248 CYS n 
1 249 ARG n 
1 250 ARG n 
1 251 PRO n 
1 252 THR n 
1 253 HIS n 
1 254 LEU n 
1 255 SER n 
1 256 ALA n 
1 257 VAL n 
1 258 VAL n 
1 259 CYS n 
1 260 VAL n 
1 261 LEU n 
1 262 LEU n 
1 263 TRP n 
1 264 GLY n 
1 265 LEU n 
1 266 SER n 
1 267 LEU n 
1 268 LEU n 
1 269 PHE n 
1 270 SER n 
1 271 MET n 
1 272 LEU n 
1 273 GLU n 
1 274 TRP n 
1 275 ARG n 
1 276 PHE n 
1 277 CYS n 
1 278 ASP n 
1 279 PHE n 
1 280 LEU n 
1 281 PHE n 
1 282 SER n 
1 283 GLY n 
1 284 ALA n 
1 285 ASP n 
1 286 SER n 
1 287 SER n 
1 288 TRP n 
1 289 CYS n 
1 290 GLU n 
1 291 THR n 
1 292 SER n 
1 293 ASP n 
1 294 PHE n 
1 295 ILE n 
1 296 PRO n 
1 297 VAL n 
1 298 ALA n 
1 299 TRP n 
1 300 LEU n 
1 301 ILE n 
1 302 PHE n 
1 303 LEU n 
1 304 CYS n 
1 305 VAL n 
1 306 VAL n 
1 307 LEU n 
1 308 CYS n 
1 309 VAL n 
1 310 SER n 
1 311 SER n 
1 312 LEU n 
1 313 VAL n 
1 314 LEU n 
1 315 LEU n 
1 316 VAL n 
1 317 ARG n 
1 318 ILE n 
1 319 LEU n 
1 320 CYS n 
1 321 GLY n 
1 322 SER n 
1 323 ARG n 
1 324 LYS n 
1 325 MET n 
1 326 PRO n 
1 327 LEU n 
1 328 THR n 
1 329 ARG n 
1 330 LEU n 
1 331 TYR n 
1 332 VAL n 
1 333 THR n 
1 334 ILE n 
1 335 LEU n 
1 336 LEU n 
1 337 THR n 
1 338 VAL n 
1 339 LEU n 
1 340 VAL n 
1 341 PHE n 
1 342 LEU n 
1 343 LEU n 
1 344 CYS n 
1 345 GLY n 
1 346 LEU n 
1 347 PRO n 
1 348 PHE n 
1 349 GLY n 
1 350 ILE n 
1 351 LEU n 
1 352 GLY n 
1 353 ALA n 
1 354 LEU n 
1 355 ILE n 
1 356 TYR n 
1 357 ARG n 
1 358 MET n 
1 359 HIS n 
1 360 LEU n 
1 361 ASN n 
1 362 LEU n 
1 363 GLU n 
1 364 VAL n 
1 365 LEU n 
1 366 TYR n 
1 367 CYS n 
1 368 HIS n 
1 369 VAL n 
1 370 TYR n 
1 371 LEU n 
1 372 VAL n 
1 373 CYS n 
1 374 MET n 
1 375 SER n 
1 376 LEU n 
1 377 SER n 
1 378 SER n 
1 379 LEU n 
1 380 ASN n 
1 381 SER n 
1 382 SER n 
1 383 ALA n 
1 384 ASN n 
1 385 PRO n 
1 386 ILE n 
1 387 ILE n 
1 388 TYR n 
1 389 PHE n 
1 390 PHE n 
1 391 VAL n 
1 392 GLY n 
1 393 SER n 
1 394 PHE n 
1 395 ARG n 
1 396 GLN n 
1 397 ARG n 
1 398 GLN n 
1 399 ASN n 
1 400 ARG n 
1 401 GLN n 
1 402 ASN n 
1 403 LEU n 
1 404 LYS n 
1 405 LEU n 
1 406 VAL n 
1 407 LEU n 
1 408 GLN n 
1 409 ARG n 
1 410 ALA n 
1 411 LEU n 
1 412 GLN n 
1 413 ASP n 
1 414 LYS n 
1 415 PRO n 
1 416 GLU n 
1 417 VAL n 
1 418 ASP n 
1 419 LYS n 
1 420 GLY n 
1 421 GLU n 
1 422 GLY n 
1 423 GLN n 
1 424 LEU n 
1 425 PRO n 
1 426 GLU n 
1 427 GLU n 
1 428 SER n 
1 429 LEU n 
1 430 GLU n 
1 431 LEU n 
1 432 SER n 
1 433 GLY n 
1 434 SER n 
1 435 ARG n 
1 436 LEU n 
1 437 GLY n 
1 438 PRO n 
1 439 LEU n 
1 440 GLU n 
1 441 LEU n 
1 442 GLU n 
1 443 VAL n 
1 444 LEU n 
1 445 PHE n 
1 446 GLN n 
1 447 GLY n 
1 448 PRO n 
1 449 SER n 
1 450 LYS n 
1 451 GLY n 
1 452 GLU n 
1 453 GLU n 
1 454 LEU n 
1 455 PHE n 
1 456 THR n 
1 457 GLY n 
1 458 VAL n 
1 459 VAL n 
1 460 PRO n 
1 461 ILE n 
1 462 LEU n 
1 463 VAL n 
1 464 GLU n 
1 465 LEU n 
1 466 ASP n 
1 467 GLY n 
1 468 ASP n 
1 469 VAL n 
1 470 ASN n 
1 471 GLY n 
1 472 HIS n 
1 473 LYS n 
1 474 PHE n 
1 475 SER n 
1 476 VAL n 
1 477 ARG n 
1 478 GLY n 
1 479 GLU n 
1 480 GLY n 
1 481 GLU n 
1 482 GLY n 
1 483 ASP n 
1 484 ALA n 
1 485 THR n 
1 486 ASN n 
1 487 GLY n 
1 488 LYS n 
1 489 LEU n 
1 490 THR n 
1 491 LEU n 
1 492 LYS n 
1 493 PHE n 
1 494 ILE n 
1 495 CYS n 
1 496 THR n 
1 497 THR n 
1 498 GLY n 
1 499 LYS n 
1 500 LEU n 
1 501 PRO n 
1 502 VAL n 
1 503 PRO n 
1 504 TRP n 
1 505 PRO n 
1 506 THR n 
1 507 LEU n 
1 508 VAL n 
1 509 THR n 
1 510 THR n 
1 511 LEU n 
1 512 THR n 
1 513 TYR n 
1 514 GLY n 
1 515 VAL n 
1 516 GLN n 
1 517 CYS n 
1 518 PHE n 
1 519 SER n 
1 520 ARG n 
1 521 TYR n 
1 522 PRO n 
1 523 ASP n 
1 524 HIS n 
1 525 MET n 
1 526 LYS n 
1 527 ARG n 
1 528 HIS n 
1 529 ASP n 
1 530 PHE n 
1 531 PHE n 
1 532 LYS n 
1 533 SER n 
1 534 ALA n 
1 535 MET n 
1 536 PRO n 
1 537 GLU n 
1 538 GLY n 
1 539 TYR n 
1 540 VAL n 
1 541 GLN n 
1 542 GLU n 
1 543 ARG n 
1 544 THR n 
1 545 ILE n 
1 546 SER n 
1 547 PHE n 
1 548 LYS n 
1 549 ASP n 
1 550 ASP n 
1 551 GLY n 
1 552 THR n 
1 553 TYR n 
1 554 LYS n 
1 555 THR n 
1 556 ARG n 
1 557 ALA n 
1 558 GLU n 
1 559 VAL n 
1 560 LYS n 
1 561 PHE n 
1 562 GLU n 
1 563 GLY n 
1 564 ASP n 
1 565 THR n 
1 566 LEU n 
1 567 VAL n 
1 568 ASN n 
1 569 ARG n 
1 570 ILE n 
1 571 GLU n 
1 572 LEU n 
1 573 LYS n 
1 574 GLY n 
1 575 ILE n 
1 576 ASP n 
1 577 PHE n 
1 578 LYS n 
1 579 GLU n 
1 580 ASP n 
1 581 GLY n 
1 582 ASN n 
1 583 ILE n 
1 584 LEU n 
1 585 GLY n 
1 586 HIS n 
1 587 LYS n 
1 588 LEU n 
1 589 GLU n 
1 590 TYR n 
1 591 ASN n 
1 592 PHE n 
1 593 ASN n 
1 594 SER n 
1 595 HIS n 
1 596 ASN n 
1 597 VAL n 
1 598 TYR n 
1 599 ILE n 
1 600 THR n 
1 601 ALA n 
1 602 ASP n 
1 603 LYS n 
1 604 GLN n 
1 605 LYS n 
1 606 ASN n 
1 607 GLY n 
1 608 ILE n 
1 609 LYS n 
1 610 ALA n 
1 611 ASN n 
1 612 PHE n 
1 613 LYS n 
1 614 ILE n 
1 615 ARG n 
1 616 HIS n 
1 617 ASN n 
1 618 VAL n 
1 619 GLU n 
1 620 ASP n 
1 621 GLY n 
1 622 SER n 
1 623 VAL n 
1 624 GLN n 
1 625 LEU n 
1 626 ALA n 
1 627 ASP n 
1 628 HIS n 
1 629 TYR n 
1 630 GLN n 
1 631 GLN n 
1 632 ASN n 
1 633 THR n 
1 634 PRO n 
1 635 ILE n 
1 636 GLY n 
1 637 ASP n 
1 638 GLY n 
1 639 PRO n 
1 640 VAL n 
1 641 LEU n 
1 642 LEU n 
1 643 PRO n 
1 644 ASP n 
1 645 ASN n 
1 646 HIS n 
1 647 TYR n 
1 648 LEU n 
1 649 SER n 
1 650 THR n 
1 651 GLN n 
1 652 SER n 
1 653 VAL n 
1 654 LEU n 
1 655 SER n 
1 656 LYS n 
1 657 ASP n 
1 658 PRO n 
1 659 ASN n 
1 660 GLU n 
1 661 LYS n 
1 662 ARG n 
1 663 ASP n 
1 664 HIS n 
1 665 MET n 
1 666 VAL n 
1 667 LEU n 
1 668 LEU n 
1 669 GLU n 
1 670 PHE n 
1 671 VAL n 
1 672 THR n 
1 673 ALA n 
1 674 ALA n 
1 675 GLY n 
1 676 ILE n 
1 677 THR n 
1 678 HIS n 
1 679 GLY n 
1 680 MET n 
1 681 ASP n 
1 682 GLU n 
1 683 TRP n 
1 684 SER n 
1 685 HIS n 
1 686 PRO n 
1 687 GLN n 
1 688 PHE n 
1 689 GLU n 
1 690 LYS n 
1 691 GLY n 
1 692 GLY n 
1 693 GLY n 
1 694 SER n 
1 695 GLY n 
1 696 GLY n 
1 697 GLY n 
1 698 SER n 
1 699 GLY n 
1 700 GLY n 
1 701 SER n 
1 702 ALA n 
1 703 TRP n 
1 704 SER n 
1 705 HIS n 
1 706 PRO n 
1 707 GLN n 
1 708 PHE n 
1 709 GLU n 
1 710 LYS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1   116 ?                                    ? cybC                           ? ? ? ? ? ? 
'Escherichia coli'  562  ? ? ? ? ? ? ? ? 'Spodoptera frugiperda' 7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
1 2 sample 'Biological sequence' 117 438 human                                ? 'MRGPRX4, MRGX4, SNSR5, SNSR6' ? ? ? ? ? ? 
'Homo sapiens'      9606 ? ? ? ? ? ? ? ? 'Spodoptera frugiperda' 7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
1 3 sample 'Biological sequence' 439 710 'Water jellyfish, Mesonema victoria' ? GFP                            ? ? ? ? ? ? 
'Aequorea victoria' 6100 ? ? ? ? ? ? ? ? 'Spodoptera frugiperda' 7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'    131.173 
JW0 non-polymer         . 
;(4~{R})-4-[(3~{R},5~{R},8~{R},9~{S},10~{S},12~{S},13~{R},14~{S},17~{R})-10,13-dimethyl-12-oxidanyl-3-phosphonooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{H}-cyclopenta[a]phenanthren-17-yl]pentanoic acid
;
? 'C24 H41 O7 P'   472.552 
LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ASP 1   -115 ?   ?   ?   E . n 
A 1 2   TYR 2   -114 ?   ?   ?   E . n 
A 1 3   LYS 3   -113 ?   ?   ?   E . n 
A 1 4   ASP 4   -112 ?   ?   ?   E . n 
A 1 5   ASP 5   -111 ?   ?   ?   E . n 
A 1 6   ASP 6   -110 ?   ?   ?   E . n 
A 1 7   ASP 7   -109 ?   ?   ?   E . n 
A 1 8   LYS 8   -108 ?   ?   ?   E . n 
A 1 9   GLU 9   -107 ?   ?   ?   E . n 
A 1 10  PHE 10  -106 ?   ?   ?   E . n 
A 1 11  ALA 11  -105 ?   ?   ?   E . n 
A 1 12  ASP 12  -104 ?   ?   ?   E . n 
A 1 13  LEU 13  -103 ?   ?   ?   E . n 
A 1 14  GLU 14  -102 ?   ?   ?   E . n 
A 1 15  ASP 15  -101 ?   ?   ?   E . n 
A 1 16  ASN 16  -100 ?   ?   ?   E . n 
A 1 17  TRP 17  -99  ?   ?   ?   E . n 
A 1 18  GLU 18  -98  ?   ?   ?   E . n 
A 1 19  THR 19  -97  ?   ?   ?   E . n 
A 1 20  LEU 20  -96  ?   ?   ?   E . n 
A 1 21  ASN 21  -95  ?   ?   ?   E . n 
A 1 22  ASP 22  -94  ?   ?   ?   E . n 
A 1 23  ASN 23  -93  ?   ?   ?   E . n 
A 1 24  LEU 24  -92  ?   ?   ?   E . n 
A 1 25  LYS 25  -91  ?   ?   ?   E . n 
A 1 26  VAL 26  -90  ?   ?   ?   E . n 
A 1 27  ILE 27  -89  ?   ?   ?   E . n 
A 1 28  GLU 28  -88  ?   ?   ?   E . n 
A 1 29  LYS 29  -87  ?   ?   ?   E . n 
A 1 30  ALA 30  -86  ?   ?   ?   E . n 
A 1 31  ASP 31  -85  ?   ?   ?   E . n 
A 1 32  ASN 32  -84  ?   ?   ?   E . n 
A 1 33  ALA 33  -83  ?   ?   ?   E . n 
A 1 34  ALA 34  -82  ?   ?   ?   E . n 
A 1 35  GLN 35  -81  ?   ?   ?   E . n 
A 1 36  VAL 36  -80  ?   ?   ?   E . n 
A 1 37  LYS 37  -79  ?   ?   ?   E . n 
A 1 38  ASP 38  -78  ?   ?   ?   E . n 
A 1 39  ALA 39  -77  ?   ?   ?   E . n 
A 1 40  LEU 40  -76  ?   ?   ?   E . n 
A 1 41  THR 41  -75  ?   ?   ?   E . n 
A 1 42  LYS 42  -74  ?   ?   ?   E . n 
A 1 43  MET 43  -73  ?   ?   ?   E . n 
A 1 44  ARG 44  -72  ?   ?   ?   E . n 
A 1 45  ALA 45  -71  ?   ?   ?   E . n 
A 1 46  ALA 46  -70  ?   ?   ?   E . n 
A 1 47  ALA 47  -69  ?   ?   ?   E . n 
A 1 48  LEU 48  -68  ?   ?   ?   E . n 
A 1 49  ASP 49  -67  ?   ?   ?   E . n 
A 1 50  ALA 50  -66  ?   ?   ?   E . n 
A 1 51  GLN 51  -65  ?   ?   ?   E . n 
A 1 52  LYS 52  -64  ?   ?   ?   E . n 
A 1 53  ALA 53  -63  ?   ?   ?   E . n 
A 1 54  THR 54  -62  ?   ?   ?   E . n 
A 1 55  PRO 55  -61  ?   ?   ?   E . n 
A 1 56  PRO 56  -60  ?   ?   ?   E . n 
A 1 57  LYS 57  -59  ?   ?   ?   E . n 
A 1 58  LEU 58  -58  ?   ?   ?   E . n 
A 1 59  GLU 59  -57  ?   ?   ?   E . n 
A 1 60  ASP 60  -56  ?   ?   ?   E . n 
A 1 61  LYS 61  -55  ?   ?   ?   E . n 
A 1 62  SER 62  -54  ?   ?   ?   E . n 
A 1 63  PRO 63  -53  ?   ?   ?   E . n 
A 1 64  ASP 64  -52  ?   ?   ?   E . n 
A 1 65  SER 65  -51  ?   ?   ?   E . n 
A 1 66  PRO 66  -50  ?   ?   ?   E . n 
A 1 67  GLU 67  -49  ?   ?   ?   E . n 
A 1 68  MET 68  -48  ?   ?   ?   E . n 
A 1 69  LYS 69  -47  ?   ?   ?   E . n 
A 1 70  ASP 70  -46  ?   ?   ?   E . n 
A 1 71  PHE 71  -45  ?   ?   ?   E . n 
A 1 72  ARG 72  -44  ?   ?   ?   E . n 
A 1 73  HIS 73  -43  ?   ?   ?   E . n 
A 1 74  GLY 74  -42  ?   ?   ?   E . n 
A 1 75  PHE 75  -41  ?   ?   ?   E . n 
A 1 76  ASP 76  -40  ?   ?   ?   E . n 
A 1 77  ILE 77  -39  ?   ?   ?   E . n 
A 1 78  LEU 78  -38  ?   ?   ?   E . n 
A 1 79  VAL 79  -37  ?   ?   ?   E . n 
A 1 80  GLY 80  -36  ?   ?   ?   E . n 
A 1 81  GLN 81  -35  ?   ?   ?   E . n 
A 1 82  ILE 82  -34  ?   ?   ?   E . n 
A 1 83  ASP 83  -33  ?   ?   ?   E . n 
A 1 84  ASP 84  -32  ?   ?   ?   E . n 
A 1 85  ALA 85  -31  ?   ?   ?   E . n 
A 1 86  LEU 86  -30  ?   ?   ?   E . n 
A 1 87  LYS 87  -29  ?   ?   ?   E . n 
A 1 88  LEU 88  -28  ?   ?   ?   E . n 
A 1 89  ALA 89  -27  ?   ?   ?   E . n 
A 1 90  ASN 90  -26  ?   ?   ?   E . n 
A 1 91  GLU 91  -25  ?   ?   ?   E . n 
A 1 92  GLY 92  -24  ?   ?   ?   E . n 
A 1 93  LYS 93  -23  ?   ?   ?   E . n 
A 1 94  VAL 94  -22  ?   ?   ?   E . n 
A 1 95  LYS 95  -21  ?   ?   ?   E . n 
A 1 96  GLU 96  -20  ?   ?   ?   E . n 
A 1 97  ALA 97  -19  ?   ?   ?   E . n 
A 1 98  GLN 98  -18  ?   ?   ?   E . n 
A 1 99  ALA 99  -17  ?   ?   ?   E . n 
A 1 100 ALA 100 -16  ?   ?   ?   E . n 
A 1 101 ALA 101 -15  ?   ?   ?   E . n 
A 1 102 GLU 102 -14  ?   ?   ?   E . n 
A 1 103 GLN 103 -13  ?   ?   ?   E . n 
A 1 104 LEU 104 -12  ?   ?   ?   E . n 
A 1 105 LYS 105 -11  ?   ?   ?   E . n 
A 1 106 THR 106 -10  ?   ?   ?   E . n 
A 1 107 THR 107 -9   ?   ?   ?   E . n 
A 1 108 ARG 108 -8   ?   ?   ?   E . n 
A 1 109 ASN 109 -7   ?   ?   ?   E . n 
A 1 110 ALA 110 -6   ?   ?   ?   E . n 
A 1 111 TYR 111 -5   ?   ?   ?   E . n 
A 1 112 ILE 112 -4   ?   ?   ?   E . n 
A 1 113 GLN 113 -3   ?   ?   ?   E . n 
A 1 114 LYS 114 -2   ?   ?   ?   E . n 
A 1 115 TYR 115 -1   ?   ?   ?   E . n 
A 1 116 LEU 116 0    ?   ?   ?   E . n 
A 1 117 MET 117 1    ?   ?   ?   E . n 
A 1 118 ASP 118 2    ?   ?   ?   E . n 
A 1 119 PRO 119 3    ?   ?   ?   E . n 
A 1 120 THR 120 4    ?   ?   ?   E . n 
A 1 121 VAL 121 5    ?   ?   ?   E . n 
A 1 122 PRO 122 6    ?   ?   ?   E . n 
A 1 123 VAL 123 7    ?   ?   ?   E . n 
A 1 124 PHE 124 8    ?   ?   ?   E . n 
A 1 125 GLY 125 9    ?   ?   ?   E . n 
A 1 126 THR 126 10   ?   ?   ?   E . n 
A 1 127 LYS 127 11   ?   ?   ?   E . n 
A 1 128 LEU 128 12   ?   ?   ?   E . n 
A 1 129 THR 129 13   ?   ?   ?   E . n 
A 1 130 PRO 130 14   ?   ?   ?   E . n 
A 1 131 ILE 131 15   ?   ?   ?   E . n 
A 1 132 ASN 132 16   ?   ?   ?   E . n 
A 1 133 GLY 133 17   ?   ?   ?   E . n 
A 1 134 ARG 134 18   ?   ?   ?   E . n 
A 1 135 GLU 135 19   ?   ?   ?   E . n 
A 1 136 GLU 136 20   ?   ?   ?   E . n 
A 1 137 THR 137 21   ?   ?   ?   E . n 
A 1 138 PRO 138 22   22  PRO PRO E . n 
A 1 139 CYS 139 23   23  CYS CYS E . n 
A 1 140 TYR 140 24   24  TYR TYR E . n 
A 1 141 ASN 141 25   25  ASN ASN E . n 
A 1 142 GLN 142 26   26  GLN GLN E . n 
A 1 143 THR 143 27   27  THR THR E . n 
A 1 144 LEU 144 28   28  LEU LEU E . n 
A 1 145 SER 145 29   29  SER SER E . n 
A 1 146 PHE 146 30   30  PHE PHE E . n 
A 1 147 THR 147 31   31  THR THR E . n 
A 1 148 VAL 148 32   32  VAL VAL E . n 
A 1 149 LEU 149 33   33  LEU LEU E . n 
A 1 150 THR 150 34   34  THR THR E . n 
A 1 151 CYS 151 35   35  CYS CYS E . n 
A 1 152 ILE 152 36   36  ILE ILE E . n 
A 1 153 ILE 153 37   37  ILE ILE E . n 
A 1 154 SER 154 38   38  SER SER E . n 
A 1 155 LEU 155 39   39  LEU LEU E . n 
A 1 156 VAL 156 40   40  VAL VAL E . n 
A 1 157 GLY 157 41   41  GLY GLY E . n 
A 1 158 LEU 158 42   42  LEU LEU E . n 
A 1 159 THR 159 43   43  THR THR E . n 
A 1 160 GLY 160 44   44  GLY GLY E . n 
A 1 161 ASN 161 45   45  ASN ASN E . n 
A 1 162 ALA 162 46   46  ALA ALA E . n 
A 1 163 VAL 163 47   47  VAL VAL E . n 
A 1 164 VAL 164 48   48  VAL VAL E . n 
A 1 165 LEU 165 49   49  LEU LEU E . n 
A 1 166 TRP 166 50   50  TRP TRP E . n 
A 1 167 LEU 167 51   51  LEU LEU E . n 
A 1 168 LEU 168 52   52  LEU LEU E . n 
A 1 169 GLY 169 53   53  GLY GLY E . n 
A 1 170 TYR 170 54   54  TYR TYR E . n 
A 1 171 ARG 171 55   55  ARG ARG E . n 
A 1 172 MET 172 56   56  MET MET E . n 
A 1 173 ARG 173 57   57  ARG ARG E . n 
A 1 174 ARG 174 58   58  ARG ARG E . n 
A 1 175 ASN 175 59   59  ASN ASN E . n 
A 1 176 ALA 176 60   60  ALA ALA E . n 
A 1 177 VAL 177 61   61  VAL VAL E . n 
A 1 178 SER 178 62   62  SER SER E . n 
A 1 179 ILE 179 63   63  ILE ILE E . n 
A 1 180 TYR 180 64   64  TYR TYR E . n 
A 1 181 ILE 181 65   65  ILE ILE E . n 
A 1 182 LEU 182 66   66  LEU LEU E . n 
A 1 183 ASN 183 67   67  ASN ASN E . n 
A 1 184 LEU 184 68   68  LEU LEU E . n 
A 1 185 ALA 185 69   69  ALA ALA E . n 
A 1 186 ALA 186 70   70  ALA ALA E . n 
A 1 187 ALA 187 71   71  ALA ALA E . n 
A 1 188 ASP 188 72   72  ASP ASP E . n 
A 1 189 PHE 189 73   73  PHE PHE E . n 
A 1 190 LEU 190 74   74  LEU LEU E . n 
A 1 191 PHE 191 75   75  PHE PHE E . n 
A 1 192 LEU 192 76   76  LEU LEU E . n 
A 1 193 SER 193 77   77  SER SER E . n 
A 1 194 PHE 194 78   78  PHE PHE E . n 
A 1 195 GLN 195 79   79  GLN GLN E . n 
A 1 196 ILE 196 80   80  ILE ILE E . n 
A 1 197 ILE 197 81   81  ILE ILE E . n 
A 1 198 ARG 198 82   82  ARG ARG E . n 
A 1 199 LEU 199 83   83  LEU LEU E . n 
A 1 200 PRO 200 84   84  PRO PRO E . n 
A 1 201 LEU 201 85   85  LEU LEU E . n 
A 1 202 ARG 202 86   86  ARG ARG E . n 
A 1 203 LEU 203 87   87  LEU LEU E . n 
A 1 204 ILE 204 88   88  ILE ILE E . n 
A 1 205 ASN 205 89   89  ASN ASN E . n 
A 1 206 ILE 206 90   90  ILE ILE E . n 
A 1 207 SER 207 91   91  SER SER E . n 
A 1 208 HIS 208 92   92  HIS HIS E . n 
A 1 209 LEU 209 93   93  LEU LEU E . n 
A 1 210 ILE 210 94   94  ILE ILE E . n 
A 1 211 ARG 211 95   95  ARG ARG E . n 
A 1 212 LYS 212 96   96  LYS LYS E . n 
A 1 213 ILE 213 97   97  ILE ILE E . n 
A 1 214 LEU 214 98   98  LEU LEU E . n 
A 1 215 VAL 215 99   99  VAL VAL E . n 
A 1 216 SER 216 100  100 SER SER E . n 
A 1 217 VAL 217 101  101 VAL VAL E . n 
A 1 218 MET 218 102  102 MET MET E . n 
A 1 219 THR 219 103  103 THR THR E . n 
A 1 220 PHE 220 104  104 PHE PHE E . n 
A 1 221 PRO 221 105  105 PRO PRO E . n 
A 1 222 TYR 222 106  106 TYR TYR E . n 
A 1 223 PHE 223 107  107 PHE PHE E . n 
A 1 224 THR 224 108  108 THR THR E . n 
A 1 225 GLY 225 109  109 GLY GLY E . n 
A 1 226 LEU 226 110  110 LEU LEU E . n 
A 1 227 SER 227 111  111 SER SER E . n 
A 1 228 MET 228 112  112 MET MET E . n 
A 1 229 LEU 229 113  113 LEU LEU E . n 
A 1 230 SER 230 114  114 SER SER E . n 
A 1 231 ALA 231 115  115 ALA ALA E . n 
A 1 232 ILE 232 116  116 ILE ILE E . n 
A 1 233 SER 233 117  117 SER SER E . n 
A 1 234 THR 234 118  118 THR THR E . n 
A 1 235 GLU 235 119  119 GLU GLU E . n 
A 1 236 ARG 236 120  120 ARG ARG E . n 
A 1 237 CYS 237 121  121 CYS CYS E . n 
A 1 238 LEU 238 122  122 LEU LEU E . n 
A 1 239 SER 239 123  123 SER SER E . n 
A 1 240 VAL 240 124  124 VAL VAL E . n 
A 1 241 LEU 241 125  125 LEU LEU E . n 
A 1 242 TRP 242 126  126 TRP TRP E . n 
A 1 243 PRO 243 127  127 PRO PRO E . n 
A 1 244 ILE 244 128  128 ILE ILE E . n 
A 1 245 TRP 245 129  129 TRP TRP E . n 
A 1 246 TYR 246 130  130 TYR TYR E . n 
A 1 247 ARG 247 131  131 ARG ARG E . n 
A 1 248 CYS 248 132  132 CYS CYS E . n 
A 1 249 ARG 249 133  133 ARG ARG E . n 
A 1 250 ARG 250 134  134 ARG ARG E . n 
A 1 251 PRO 251 135  135 PRO PRO E . n 
A 1 252 THR 252 136  136 THR THR E . n 
A 1 253 HIS 253 137  137 HIS HIS E . n 
A 1 254 LEU 254 138  138 LEU LEU E . n 
A 1 255 SER 255 139  139 SER SER E . n 
A 1 256 ALA 256 140  140 ALA ALA E . n 
A 1 257 VAL 257 141  141 VAL VAL E . n 
A 1 258 VAL 258 142  142 VAL VAL E . n 
A 1 259 CYS 259 143  143 CYS CYS E . n 
A 1 260 VAL 260 144  144 VAL VAL E . n 
A 1 261 LEU 261 145  145 LEU LEU E . n 
A 1 262 LEU 262 146  146 LEU LEU E . n 
A 1 263 TRP 263 147  147 TRP TRP E . n 
A 1 264 GLY 264 148  148 GLY GLY E . n 
A 1 265 LEU 265 149  149 LEU LEU E . n 
A 1 266 SER 266 150  150 SER SER E . n 
A 1 267 LEU 267 151  151 LEU LEU E . n 
A 1 268 LEU 268 152  152 LEU LEU E . n 
A 1 269 PHE 269 153  153 PHE PHE E . n 
A 1 270 SER 270 154  154 SER SER E . n 
A 1 271 MET 271 155  155 MET MET E . n 
A 1 272 LEU 272 156  156 LEU LEU E . n 
A 1 273 GLU 273 157  157 GLU GLU E . n 
A 1 274 TRP 274 158  158 TRP TRP E . n 
A 1 275 ARG 275 159  159 ARG ARG E . n 
A 1 276 PHE 276 160  160 PHE PHE E . n 
A 1 277 CYS 277 161  161 CYS CYS E . n 
A 1 278 ASP 278 162  162 ASP ASP E . n 
A 1 279 PHE 279 163  163 PHE PHE E . n 
A 1 280 LEU 280 164  164 LEU LEU E . n 
A 1 281 PHE 281 165  165 PHE PHE E . n 
A 1 282 SER 282 166  ?   ?   ?   E . n 
A 1 283 GLY 283 167  ?   ?   ?   E . n 
A 1 284 ALA 284 168  ?   ?   ?   E . n 
A 1 285 ASP 285 169  ?   ?   ?   E . n 
A 1 286 SER 286 170  170 SER SER E . n 
A 1 287 SER 287 171  171 SER SER E . n 
A 1 288 TRP 288 172  172 TRP TRP E . n 
A 1 289 CYS 289 173  173 CYS CYS E . n 
A 1 290 GLU 290 174  174 GLU GLU E . n 
A 1 291 THR 291 175  175 THR THR E . n 
A 1 292 SER 292 176  176 SER SER E . n 
A 1 293 ASP 293 177  177 ASP ASP E . n 
A 1 294 PHE 294 178  178 PHE PHE E . n 
A 1 295 ILE 295 179  179 ILE ILE E . n 
A 1 296 PRO 296 180  180 PRO PRO E . n 
A 1 297 VAL 297 181  181 VAL VAL E . n 
A 1 298 ALA 298 182  182 ALA ALA E . n 
A 1 299 TRP 299 183  183 TRP TRP E . n 
A 1 300 LEU 300 184  184 LEU LEU E . n 
A 1 301 ILE 301 185  185 ILE ILE E . n 
A 1 302 PHE 302 186  186 PHE PHE E . n 
A 1 303 LEU 303 187  187 LEU LEU E . n 
A 1 304 CYS 304 188  188 CYS CYS E . n 
A 1 305 VAL 305 189  189 VAL VAL E . n 
A 1 306 VAL 306 190  190 VAL VAL E . n 
A 1 307 LEU 307 191  191 LEU LEU E . n 
A 1 308 CYS 308 192  192 CYS CYS E . n 
A 1 309 VAL 309 193  193 VAL VAL E . n 
A 1 310 SER 310 194  194 SER SER E . n 
A 1 311 SER 311 195  195 SER SER E . n 
A 1 312 LEU 312 196  196 LEU LEU E . n 
A 1 313 VAL 313 197  197 VAL VAL E . n 
A 1 314 LEU 314 198  198 LEU LEU E . n 
A 1 315 LEU 315 199  199 LEU LEU E . n 
A 1 316 VAL 316 200  200 VAL VAL E . n 
A 1 317 ARG 317 201  201 ARG ARG E . n 
A 1 318 ILE 318 202  202 ILE ILE E . n 
A 1 319 LEU 319 203  203 LEU LEU E . n 
A 1 320 CYS 320 204  204 CYS CYS E . n 
A 1 321 GLY 321 205  205 GLY GLY E . n 
A 1 322 SER 322 206  206 SER SER E . n 
A 1 323 ARG 323 207  207 ARG ARG E . n 
A 1 324 LYS 324 208  208 LYS LYS E . n 
A 1 325 MET 325 209  209 MET MET E . n 
A 1 326 PRO 326 210  210 PRO PRO E . n 
A 1 327 LEU 327 211  211 LEU LEU E . n 
A 1 328 THR 328 212  212 THR THR E . n 
A 1 329 ARG 329 213  213 ARG ARG E . n 
A 1 330 LEU 330 214  214 LEU LEU E . n 
A 1 331 TYR 331 215  215 TYR TYR E . n 
A 1 332 VAL 332 216  216 VAL VAL E . n 
A 1 333 THR 333 217  217 THR THR E . n 
A 1 334 ILE 334 218  218 ILE ILE E . n 
A 1 335 LEU 335 219  219 LEU LEU E . n 
A 1 336 LEU 336 220  220 LEU LEU E . n 
A 1 337 THR 337 221  221 THR THR E . n 
A 1 338 VAL 338 222  222 VAL VAL E . n 
A 1 339 LEU 339 223  223 LEU LEU E . n 
A 1 340 VAL 340 224  224 VAL VAL E . n 
A 1 341 PHE 341 225  225 PHE PHE E . n 
A 1 342 LEU 342 226  226 LEU LEU E . n 
A 1 343 LEU 343 227  227 LEU LEU E . n 
A 1 344 CYS 344 228  228 CYS CYS E . n 
A 1 345 GLY 345 229  229 GLY GLY E . n 
A 1 346 LEU 346 230  230 LEU LEU E . n 
A 1 347 PRO 347 231  231 PRO PRO E . n 
A 1 348 PHE 348 232  232 PHE PHE E . n 
A 1 349 GLY 349 233  233 GLY GLY E . n 
A 1 350 ILE 350 234  234 ILE ILE E . n 
A 1 351 LEU 351 235  235 LEU LEU E . n 
A 1 352 GLY 352 236  236 GLY GLY E . n 
A 1 353 ALA 353 237  237 ALA ALA E . n 
A 1 354 LEU 354 238  238 LEU LEU E . n 
A 1 355 ILE 355 239  239 ILE ILE E . n 
A 1 356 TYR 356 240  240 TYR TYR E . n 
A 1 357 ARG 357 241  241 ARG ARG E . n 
A 1 358 MET 358 242  242 MET MET E . n 
A 1 359 HIS 359 243  243 HIS HIS E . n 
A 1 360 LEU 360 244  244 LEU LEU E . n 
A 1 361 ASN 361 245  245 ASN ASN E . n 
A 1 362 LEU 362 246  246 LEU LEU E . n 
A 1 363 GLU 363 247  247 GLU GLU E . n 
A 1 364 VAL 364 248  248 VAL VAL E . n 
A 1 365 LEU 365 249  249 LEU LEU E . n 
A 1 366 TYR 366 250  250 TYR TYR E . n 
A 1 367 CYS 367 251  251 CYS CYS E . n 
A 1 368 HIS 368 252  252 HIS HIS E . n 
A 1 369 VAL 369 253  253 VAL VAL E . n 
A 1 370 TYR 370 254  254 TYR TYR E . n 
A 1 371 LEU 371 255  255 LEU LEU E . n 
A 1 372 VAL 372 256  256 VAL VAL E . n 
A 1 373 CYS 373 257  257 CYS CYS E . n 
A 1 374 MET 374 258  258 MET MET E . n 
A 1 375 SER 375 259  259 SER SER E . n 
A 1 376 LEU 376 260  260 LEU LEU E . n 
A 1 377 SER 377 261  261 SER SER E . n 
A 1 378 SER 378 262  262 SER SER E . n 
A 1 379 LEU 379 263  263 LEU LEU E . n 
A 1 380 ASN 380 264  264 ASN ASN E . n 
A 1 381 SER 381 265  265 SER SER E . n 
A 1 382 SER 382 266  266 SER SER E . n 
A 1 383 ALA 383 267  267 ALA ALA E . n 
A 1 384 ASN 384 268  268 ASN ASN E . n 
A 1 385 PRO 385 269  269 PRO PRO E . n 
A 1 386 ILE 386 270  270 ILE ILE E . n 
A 1 387 ILE 387 271  271 ILE ILE E . n 
A 1 388 TYR 388 272  272 TYR TYR E . n 
A 1 389 PHE 389 273  273 PHE PHE E . n 
A 1 390 PHE 390 274  274 PHE PHE E . n 
A 1 391 VAL 391 275  275 VAL VAL E . n 
A 1 392 GLY 392 276  276 GLY GLY E . n 
A 1 393 SER 393 277  277 SER SER E . n 
A 1 394 PHE 394 278  278 PHE PHE E . n 
A 1 395 ARG 395 279  279 ARG ARG E . n 
A 1 396 GLN 396 280  280 GLN GLN E . n 
A 1 397 ARG 397 281  ?   ?   ?   E . n 
A 1 398 GLN 398 282  ?   ?   ?   E . n 
A 1 399 ASN 399 283  ?   ?   ?   E . n 
A 1 400 ARG 400 284  ?   ?   ?   E . n 
A 1 401 GLN 401 285  ?   ?   ?   E . n 
A 1 402 ASN 402 286  ?   ?   ?   E . n 
A 1 403 LEU 403 287  ?   ?   ?   E . n 
A 1 404 LYS 404 288  ?   ?   ?   E . n 
A 1 405 LEU 405 289  ?   ?   ?   E . n 
A 1 406 VAL 406 290  ?   ?   ?   E . n 
A 1 407 LEU 407 291  ?   ?   ?   E . n 
A 1 408 GLN 408 292  ?   ?   ?   E . n 
A 1 409 ARG 409 293  ?   ?   ?   E . n 
A 1 410 ALA 410 294  ?   ?   ?   E . n 
A 1 411 LEU 411 295  ?   ?   ?   E . n 
A 1 412 GLN 412 296  ?   ?   ?   E . n 
A 1 413 ASP 413 297  ?   ?   ?   E . n 
A 1 414 LYS 414 298  ?   ?   ?   E . n 
A 1 415 PRO 415 299  ?   ?   ?   E . n 
A 1 416 GLU 416 300  ?   ?   ?   E . n 
A 1 417 VAL 417 301  ?   ?   ?   E . n 
A 1 418 ASP 418 302  ?   ?   ?   E . n 
A 1 419 LYS 419 303  ?   ?   ?   E . n 
A 1 420 GLY 420 304  ?   ?   ?   E . n 
A 1 421 GLU 421 305  ?   ?   ?   E . n 
A 1 422 GLY 422 306  ?   ?   ?   E . n 
A 1 423 GLN 423 307  ?   ?   ?   E . n 
A 1 424 LEU 424 308  ?   ?   ?   E . n 
A 1 425 PRO 425 309  ?   ?   ?   E . n 
A 1 426 GLU 426 310  ?   ?   ?   E . n 
A 1 427 GLU 427 311  ?   ?   ?   E . n 
A 1 428 SER 428 312  ?   ?   ?   E . n 
A 1 429 LEU 429 313  ?   ?   ?   E . n 
A 1 430 GLU 430 314  ?   ?   ?   E . n 
A 1 431 LEU 431 315  ?   ?   ?   E . n 
A 1 432 SER 432 316  ?   ?   ?   E . n 
A 1 433 GLY 433 317  ?   ?   ?   E . n 
A 1 434 SER 434 318  ?   ?   ?   E . n 
A 1 435 ARG 435 319  ?   ?   ?   E . n 
A 1 436 LEU 436 320  ?   ?   ?   E . n 
A 1 437 GLY 437 321  ?   ?   ?   E . n 
A 1 438 PRO 438 322  ?   ?   ?   E . n 
A 1 439 LEU 439 323  ?   ?   ?   E . n 
A 1 440 GLU 440 324  ?   ?   ?   E . n 
A 1 441 LEU 441 325  ?   ?   ?   E . n 
A 1 442 GLU 442 326  ?   ?   ?   E . n 
A 1 443 VAL 443 327  ?   ?   ?   E . n 
A 1 444 LEU 444 328  ?   ?   ?   E . n 
A 1 445 PHE 445 329  ?   ?   ?   E . n 
A 1 446 GLN 446 330  ?   ?   ?   E . n 
A 1 447 GLY 447 331  ?   ?   ?   E . n 
A 1 448 PRO 448 332  ?   ?   ?   E . n 
A 1 449 SER 449 333  ?   ?   ?   E . n 
A 1 450 LYS 450 334  ?   ?   ?   E . n 
A 1 451 GLY 451 335  ?   ?   ?   E . n 
A 1 452 GLU 452 336  ?   ?   ?   E . n 
A 1 453 GLU 453 337  ?   ?   ?   E . n 
A 1 454 LEU 454 338  ?   ?   ?   E . n 
A 1 455 PHE 455 339  ?   ?   ?   E . n 
A 1 456 THR 456 340  ?   ?   ?   E . n 
A 1 457 GLY 457 341  ?   ?   ?   E . n 
A 1 458 VAL 458 342  ?   ?   ?   E . n 
A 1 459 VAL 459 343  ?   ?   ?   E . n 
A 1 460 PRO 460 344  ?   ?   ?   E . n 
A 1 461 ILE 461 345  ?   ?   ?   E . n 
A 1 462 LEU 462 346  ?   ?   ?   E . n 
A 1 463 VAL 463 347  ?   ?   ?   E . n 
A 1 464 GLU 464 348  ?   ?   ?   E . n 
A 1 465 LEU 465 349  ?   ?   ?   E . n 
A 1 466 ASP 466 350  ?   ?   ?   E . n 
A 1 467 GLY 467 351  ?   ?   ?   E . n 
A 1 468 ASP 468 352  ?   ?   ?   E . n 
A 1 469 VAL 469 353  ?   ?   ?   E . n 
A 1 470 ASN 470 354  ?   ?   ?   E . n 
A 1 471 GLY 471 355  ?   ?   ?   E . n 
A 1 472 HIS 472 356  ?   ?   ?   E . n 
A 1 473 LYS 473 357  ?   ?   ?   E . n 
A 1 474 PHE 474 358  ?   ?   ?   E . n 
A 1 475 SER 475 359  ?   ?   ?   E . n 
A 1 476 VAL 476 360  ?   ?   ?   E . n 
A 1 477 ARG 477 361  ?   ?   ?   E . n 
A 1 478 GLY 478 362  ?   ?   ?   E . n 
A 1 479 GLU 479 363  ?   ?   ?   E . n 
A 1 480 GLY 480 364  ?   ?   ?   E . n 
A 1 481 GLU 481 365  ?   ?   ?   E . n 
A 1 482 GLY 482 366  ?   ?   ?   E . n 
A 1 483 ASP 483 367  ?   ?   ?   E . n 
A 1 484 ALA 484 368  ?   ?   ?   E . n 
A 1 485 THR 485 369  ?   ?   ?   E . n 
A 1 486 ASN 486 370  ?   ?   ?   E . n 
A 1 487 GLY 487 371  ?   ?   ?   E . n 
A 1 488 LYS 488 372  ?   ?   ?   E . n 
A 1 489 LEU 489 373  ?   ?   ?   E . n 
A 1 490 THR 490 374  ?   ?   ?   E . n 
A 1 491 LEU 491 375  ?   ?   ?   E . n 
A 1 492 LYS 492 376  ?   ?   ?   E . n 
A 1 493 PHE 493 377  ?   ?   ?   E . n 
A 1 494 ILE 494 378  ?   ?   ?   E . n 
A 1 495 CYS 495 379  ?   ?   ?   E . n 
A 1 496 THR 496 380  ?   ?   ?   E . n 
A 1 497 THR 497 381  ?   ?   ?   E . n 
A 1 498 GLY 498 382  ?   ?   ?   E . n 
A 1 499 LYS 499 383  ?   ?   ?   E . n 
A 1 500 LEU 500 384  ?   ?   ?   E . n 
A 1 501 PRO 501 385  ?   ?   ?   E . n 
A 1 502 VAL 502 386  ?   ?   ?   E . n 
A 1 503 PRO 503 387  ?   ?   ?   E . n 
A 1 504 TRP 504 388  ?   ?   ?   E . n 
A 1 505 PRO 505 389  ?   ?   ?   E . n 
A 1 506 THR 506 390  ?   ?   ?   E . n 
A 1 507 LEU 507 391  ?   ?   ?   E . n 
A 1 508 VAL 508 392  ?   ?   ?   E . n 
A 1 509 THR 509 393  ?   ?   ?   E . n 
A 1 510 THR 510 394  ?   ?   ?   E . n 
A 1 511 LEU 511 395  ?   ?   ?   E . n 
A 1 512 THR 512 396  ?   ?   ?   E . n 
A 1 513 TYR 513 397  ?   ?   ?   E . n 
A 1 514 GLY 514 398  ?   ?   ?   E . n 
A 1 515 VAL 515 399  ?   ?   ?   E . n 
A 1 516 GLN 516 400  ?   ?   ?   E . n 
A 1 517 CYS 517 401  ?   ?   ?   E . n 
A 1 518 PHE 518 402  ?   ?   ?   E . n 
A 1 519 SER 519 403  ?   ?   ?   E . n 
A 1 520 ARG 520 404  ?   ?   ?   E . n 
A 1 521 TYR 521 405  ?   ?   ?   E . n 
A 1 522 PRO 522 406  ?   ?   ?   E . n 
A 1 523 ASP 523 407  ?   ?   ?   E . n 
A 1 524 HIS 524 408  ?   ?   ?   E . n 
A 1 525 MET 525 409  ?   ?   ?   E . n 
A 1 526 LYS 526 410  ?   ?   ?   E . n 
A 1 527 ARG 527 411  ?   ?   ?   E . n 
A 1 528 HIS 528 412  ?   ?   ?   E . n 
A 1 529 ASP 529 413  ?   ?   ?   E . n 
A 1 530 PHE 530 414  ?   ?   ?   E . n 
A 1 531 PHE 531 415  ?   ?   ?   E . n 
A 1 532 LYS 532 416  ?   ?   ?   E . n 
A 1 533 SER 533 417  ?   ?   ?   E . n 
A 1 534 ALA 534 418  ?   ?   ?   E . n 
A 1 535 MET 535 419  ?   ?   ?   E . n 
A 1 536 PRO 536 420  ?   ?   ?   E . n 
A 1 537 GLU 537 421  ?   ?   ?   E . n 
A 1 538 GLY 538 422  ?   ?   ?   E . n 
A 1 539 TYR 539 423  ?   ?   ?   E . n 
A 1 540 VAL 540 424  ?   ?   ?   E . n 
A 1 541 GLN 541 425  ?   ?   ?   E . n 
A 1 542 GLU 542 426  ?   ?   ?   E . n 
A 1 543 ARG 543 427  ?   ?   ?   E . n 
A 1 544 THR 544 428  ?   ?   ?   E . n 
A 1 545 ILE 545 429  ?   ?   ?   E . n 
A 1 546 SER 546 430  ?   ?   ?   E . n 
A 1 547 PHE 547 431  ?   ?   ?   E . n 
A 1 548 LYS 548 432  ?   ?   ?   E . n 
A 1 549 ASP 549 433  ?   ?   ?   E . n 
A 1 550 ASP 550 434  ?   ?   ?   E . n 
A 1 551 GLY 551 435  ?   ?   ?   E . n 
A 1 552 THR 552 436  ?   ?   ?   E . n 
A 1 553 TYR 553 437  ?   ?   ?   E . n 
A 1 554 LYS 554 438  ?   ?   ?   E . n 
A 1 555 THR 555 439  ?   ?   ?   E . n 
A 1 556 ARG 556 440  ?   ?   ?   E . n 
A 1 557 ALA 557 441  ?   ?   ?   E . n 
A 1 558 GLU 558 442  ?   ?   ?   E . n 
A 1 559 VAL 559 443  ?   ?   ?   E . n 
A 1 560 LYS 560 444  ?   ?   ?   E . n 
A 1 561 PHE 561 445  ?   ?   ?   E . n 
A 1 562 GLU 562 446  ?   ?   ?   E . n 
A 1 563 GLY 563 447  ?   ?   ?   E . n 
A 1 564 ASP 564 448  ?   ?   ?   E . n 
A 1 565 THR 565 449  ?   ?   ?   E . n 
A 1 566 LEU 566 450  ?   ?   ?   E . n 
A 1 567 VAL 567 451  ?   ?   ?   E . n 
A 1 568 ASN 568 452  ?   ?   ?   E . n 
A 1 569 ARG 569 453  ?   ?   ?   E . n 
A 1 570 ILE 570 454  ?   ?   ?   E . n 
A 1 571 GLU 571 455  ?   ?   ?   E . n 
A 1 572 LEU 572 456  ?   ?   ?   E . n 
A 1 573 LYS 573 457  ?   ?   ?   E . n 
A 1 574 GLY 574 458  ?   ?   ?   E . n 
A 1 575 ILE 575 459  ?   ?   ?   E . n 
A 1 576 ASP 576 460  ?   ?   ?   E . n 
A 1 577 PHE 577 461  ?   ?   ?   E . n 
A 1 578 LYS 578 462  ?   ?   ?   E . n 
A 1 579 GLU 579 463  ?   ?   ?   E . n 
A 1 580 ASP 580 464  ?   ?   ?   E . n 
A 1 581 GLY 581 465  ?   ?   ?   E . n 
A 1 582 ASN 582 466  ?   ?   ?   E . n 
A 1 583 ILE 583 467  ?   ?   ?   E . n 
A 1 584 LEU 584 468  ?   ?   ?   E . n 
A 1 585 GLY 585 469  ?   ?   ?   E . n 
A 1 586 HIS 586 470  ?   ?   ?   E . n 
A 1 587 LYS 587 471  ?   ?   ?   E . n 
A 1 588 LEU 588 472  ?   ?   ?   E . n 
A 1 589 GLU 589 473  ?   ?   ?   E . n 
A 1 590 TYR 590 474  ?   ?   ?   E . n 
A 1 591 ASN 591 475  ?   ?   ?   E . n 
A 1 592 PHE 592 476  ?   ?   ?   E . n 
A 1 593 ASN 593 477  ?   ?   ?   E . n 
A 1 594 SER 594 478  ?   ?   ?   E . n 
A 1 595 HIS 595 479  ?   ?   ?   E . n 
A 1 596 ASN 596 480  ?   ?   ?   E . n 
A 1 597 VAL 597 481  ?   ?   ?   E . n 
A 1 598 TYR 598 482  ?   ?   ?   E . n 
A 1 599 ILE 599 483  ?   ?   ?   E . n 
A 1 600 THR 600 484  ?   ?   ?   E . n 
A 1 601 ALA 601 485  ?   ?   ?   E . n 
A 1 602 ASP 602 486  ?   ?   ?   E . n 
A 1 603 LYS 603 487  ?   ?   ?   E . n 
A 1 604 GLN 604 488  ?   ?   ?   E . n 
A 1 605 LYS 605 489  ?   ?   ?   E . n 
A 1 606 ASN 606 490  ?   ?   ?   E . n 
A 1 607 GLY 607 491  ?   ?   ?   E . n 
A 1 608 ILE 608 492  ?   ?   ?   E . n 
A 1 609 LYS 609 493  ?   ?   ?   E . n 
A 1 610 ALA 610 494  ?   ?   ?   E . n 
A 1 611 ASN 611 495  ?   ?   ?   E . n 
A 1 612 PHE 612 496  ?   ?   ?   E . n 
A 1 613 LYS 613 497  ?   ?   ?   E . n 
A 1 614 ILE 614 498  ?   ?   ?   E . n 
A 1 615 ARG 615 499  ?   ?   ?   E . n 
A 1 616 HIS 616 500  ?   ?   ?   E . n 
A 1 617 ASN 617 501  ?   ?   ?   E . n 
A 1 618 VAL 618 502  ?   ?   ?   E . n 
A 1 619 GLU 619 503  ?   ?   ?   E . n 
A 1 620 ASP 620 504  ?   ?   ?   E . n 
A 1 621 GLY 621 505  ?   ?   ?   E . n 
A 1 622 SER 622 506  ?   ?   ?   E . n 
A 1 623 VAL 623 507  ?   ?   ?   E . n 
A 1 624 GLN 624 508  ?   ?   ?   E . n 
A 1 625 LEU 625 509  ?   ?   ?   E . n 
A 1 626 ALA 626 510  ?   ?   ?   E . n 
A 1 627 ASP 627 511  ?   ?   ?   E . n 
A 1 628 HIS 628 512  ?   ?   ?   E . n 
A 1 629 TYR 629 513  ?   ?   ?   E . n 
A 1 630 GLN 630 514  ?   ?   ?   E . n 
A 1 631 GLN 631 515  ?   ?   ?   E . n 
A 1 632 ASN 632 516  ?   ?   ?   E . n 
A 1 633 THR 633 517  ?   ?   ?   E . n 
A 1 634 PRO 634 518  ?   ?   ?   E . n 
A 1 635 ILE 635 519  ?   ?   ?   E . n 
A 1 636 GLY 636 520  ?   ?   ?   E . n 
A 1 637 ASP 637 521  ?   ?   ?   E . n 
A 1 638 GLY 638 522  ?   ?   ?   E . n 
A 1 639 PRO 639 523  ?   ?   ?   E . n 
A 1 640 VAL 640 524  ?   ?   ?   E . n 
A 1 641 LEU 641 525  ?   ?   ?   E . n 
A 1 642 LEU 642 526  ?   ?   ?   E . n 
A 1 643 PRO 643 527  ?   ?   ?   E . n 
A 1 644 ASP 644 528  ?   ?   ?   E . n 
A 1 645 ASN 645 529  ?   ?   ?   E . n 
A 1 646 HIS 646 530  ?   ?   ?   E . n 
A 1 647 TYR 647 531  ?   ?   ?   E . n 
A 1 648 LEU 648 532  ?   ?   ?   E . n 
A 1 649 SER 649 533  ?   ?   ?   E . n 
A 1 650 THR 650 534  ?   ?   ?   E . n 
A 1 651 GLN 651 535  ?   ?   ?   E . n 
A 1 652 SER 652 536  ?   ?   ?   E . n 
A 1 653 VAL 653 537  ?   ?   ?   E . n 
A 1 654 LEU 654 538  ?   ?   ?   E . n 
A 1 655 SER 655 539  ?   ?   ?   E . n 
A 1 656 LYS 656 540  ?   ?   ?   E . n 
A 1 657 ASP 657 541  ?   ?   ?   E . n 
A 1 658 PRO 658 542  ?   ?   ?   E . n 
A 1 659 ASN 659 543  ?   ?   ?   E . n 
A 1 660 GLU 660 544  ?   ?   ?   E . n 
A 1 661 LYS 661 545  ?   ?   ?   E . n 
A 1 662 ARG 662 546  ?   ?   ?   E . n 
A 1 663 ASP 663 547  ?   ?   ?   E . n 
A 1 664 HIS 664 548  ?   ?   ?   E . n 
A 1 665 MET 665 549  ?   ?   ?   E . n 
A 1 666 VAL 666 550  ?   ?   ?   E . n 
A 1 667 LEU 667 551  ?   ?   ?   E . n 
A 1 668 LEU 668 552  ?   ?   ?   E . n 
A 1 669 GLU 669 553  ?   ?   ?   E . n 
A 1 670 PHE 670 554  ?   ?   ?   E . n 
A 1 671 VAL 671 555  ?   ?   ?   E . n 
A 1 672 THR 672 556  ?   ?   ?   E . n 
A 1 673 ALA 673 557  ?   ?   ?   E . n 
A 1 674 ALA 674 558  ?   ?   ?   E . n 
A 1 675 GLY 675 559  ?   ?   ?   E . n 
A 1 676 ILE 676 560  ?   ?   ?   E . n 
A 1 677 THR 677 561  ?   ?   ?   E . n 
A 1 678 HIS 678 562  ?   ?   ?   E . n 
A 1 679 GLY 679 563  ?   ?   ?   E . n 
A 1 680 MET 680 564  ?   ?   ?   E . n 
A 1 681 ASP 681 565  ?   ?   ?   E . n 
A 1 682 GLU 682 566  ?   ?   ?   E . n 
A 1 683 TRP 683 567  ?   ?   ?   E . n 
A 1 684 SER 684 568  ?   ?   ?   E . n 
A 1 685 HIS 685 569  ?   ?   ?   E . n 
A 1 686 PRO 686 570  ?   ?   ?   E . n 
A 1 687 GLN 687 571  ?   ?   ?   E . n 
A 1 688 PHE 688 572  ?   ?   ?   E . n 
A 1 689 GLU 689 573  ?   ?   ?   E . n 
A 1 690 LYS 690 574  ?   ?   ?   E . n 
A 1 691 GLY 691 575  ?   ?   ?   E . n 
A 1 692 GLY 692 576  ?   ?   ?   E . n 
A 1 693 GLY 693 577  ?   ?   ?   E . n 
A 1 694 SER 694 578  ?   ?   ?   E . n 
A 1 695 GLY 695 579  ?   ?   ?   E . n 
A 1 696 GLY 696 580  ?   ?   ?   E . n 
A 1 697 GLY 697 581  ?   ?   ?   E . n 
A 1 698 SER 698 582  ?   ?   ?   E . n 
A 1 699 GLY 699 583  ?   ?   ?   E . n 
A 1 700 GLY 700 584  ?   ?   ?   E . n 
A 1 701 SER 701 585  ?   ?   ?   E . n 
A 1 702 ALA 702 586  ?   ?   ?   E . n 
A 1 703 TRP 703 587  ?   ?   ?   E . n 
A 1 704 SER 704 588  ?   ?   ?   E . n 
A 1 705 HIS 705 589  ?   ?   ?   E . n 
A 1 706 PRO 706 590  ?   ?   ?   E . n 
A 1 707 GLN 707 591  ?   ?   ?   E . n 
A 1 708 PHE 708 592  ?   ?   ?   E . n 
A 1 709 GLU 709 593  ?   ?   ?   E . n 
A 1 710 LYS 710 594  ?   ?   ?   E . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        JW0 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   JW0 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
_pdbx_nonpoly_scheme.asym_id         B 
_pdbx_nonpoly_scheme.entity_id       2 
_pdbx_nonpoly_scheme.mon_id          JW0 
_pdbx_nonpoly_scheme.ndb_seq_num     1 
_pdbx_nonpoly_scheme.pdb_seq_num     601 
_pdbx_nonpoly_scheme.auth_seq_num    301 
_pdbx_nonpoly_scheme.pdb_mon_id      JW0 
_pdbx_nonpoly_scheme.auth_mon_id     D3P 
_pdbx_nonpoly_scheme.pdb_strand_id   E 
_pdbx_nonpoly_scheme.pdb_ins_code    . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 E GLN 26  ? CG  ? A GLN 142 CG  
2  1 Y 1 E GLN 26  ? CD  ? A GLN 142 CD  
3  1 Y 1 E GLN 26  ? OE1 ? A GLN 142 OE1 
4  1 Y 1 E GLN 26  ? NE2 ? A GLN 142 NE2 
5  1 Y 1 E VAL 32  ? CG1 ? A VAL 148 CG1 
6  1 Y 1 E VAL 32  ? CG2 ? A VAL 148 CG2 
7  1 Y 1 E LEU 33  ? CG  ? A LEU 149 CG  
8  1 Y 1 E LEU 33  ? CD1 ? A LEU 149 CD1 
9  1 Y 1 E LEU 33  ? CD2 ? A LEU 149 CD2 
10 1 Y 1 E ILE 36  ? CG1 ? A ILE 152 CG1 
11 1 Y 1 E ILE 36  ? CG2 ? A ILE 152 CG2 
12 1 Y 1 E ILE 36  ? CD1 ? A ILE 152 CD1 
13 1 Y 1 E SER 38  ? OG  ? A SER 154 OG  
14 1 Y 1 E MET 56  ? CG  ? A MET 172 CG  
15 1 Y 1 E MET 56  ? SD  ? A MET 172 SD  
16 1 Y 1 E MET 56  ? CE  ? A MET 172 CE  
17 1 Y 1 E ARG 57  ? CG  ? A ARG 173 CG  
18 1 Y 1 E ARG 57  ? CD  ? A ARG 173 CD  
19 1 Y 1 E ARG 57  ? NE  ? A ARG 173 NE  
20 1 Y 1 E ARG 57  ? CZ  ? A ARG 173 CZ  
21 1 Y 1 E ARG 57  ? NH1 ? A ARG 173 NH1 
22 1 Y 1 E ARG 57  ? NH2 ? A ARG 173 NH2 
23 1 Y 1 E PHE 73  ? CG  ? A PHE 189 CG  
24 1 Y 1 E PHE 73  ? CD1 ? A PHE 189 CD1 
25 1 Y 1 E PHE 73  ? CD2 ? A PHE 189 CD2 
26 1 Y 1 E PHE 73  ? CE1 ? A PHE 189 CE1 
27 1 Y 1 E PHE 73  ? CE2 ? A PHE 189 CE2 
28 1 Y 1 E PHE 73  ? CZ  ? A PHE 189 CZ  
29 1 Y 1 E SER 154 ? OG  ? A SER 270 OG  
30 1 Y 1 E LEU 156 ? CG  ? A LEU 272 CG  
31 1 Y 1 E LEU 156 ? CD1 ? A LEU 272 CD1 
32 1 Y 1 E LEU 156 ? CD2 ? A LEU 272 CD2 
33 1 Y 1 E ARG 159 ? CG  ? A ARG 275 CG  
34 1 Y 1 E ARG 159 ? CD  ? A ARG 275 CD  
35 1 Y 1 E ARG 159 ? NE  ? A ARG 275 NE  
36 1 Y 1 E ARG 159 ? CZ  ? A ARG 275 CZ  
37 1 Y 1 E ARG 159 ? NH1 ? A ARG 275 NH1 
38 1 Y 1 E ARG 159 ? NH2 ? A ARG 275 NH2 
39 1 Y 1 E PHE 163 ? CG  ? A PHE 279 CG  
40 1 Y 1 E PHE 163 ? CD1 ? A PHE 279 CD1 
41 1 Y 1 E PHE 163 ? CD2 ? A PHE 279 CD2 
42 1 Y 1 E PHE 163 ? CE1 ? A PHE 279 CE1 
43 1 Y 1 E PHE 163 ? CE2 ? A PHE 279 CE2 
44 1 Y 1 E PHE 163 ? CZ  ? A PHE 279 CZ  
45 1 Y 1 E PHE 178 ? CG  ? A PHE 294 CG  
46 1 Y 1 E PHE 178 ? CD1 ? A PHE 294 CD1 
47 1 Y 1 E PHE 178 ? CD2 ? A PHE 294 CD2 
48 1 Y 1 E PHE 178 ? CE1 ? A PHE 294 CE1 
49 1 Y 1 E PHE 178 ? CE2 ? A PHE 294 CE2 
50 1 Y 1 E PHE 178 ? CZ  ? A PHE 294 CZ  
51 1 Y 1 E ARG 207 ? CG  ? A ARG 323 CG  
52 1 Y 1 E ARG 207 ? CD  ? A ARG 323 CD  
53 1 Y 1 E ARG 207 ? NE  ? A ARG 323 NE  
54 1 Y 1 E ARG 207 ? CZ  ? A ARG 323 CZ  
55 1 Y 1 E ARG 207 ? NH1 ? A ARG 323 NH1 
56 1 Y 1 E ARG 207 ? NH2 ? A ARG 323 NH2 
57 1 Y 1 E LYS 208 ? CG  ? A LYS 324 CG  
58 1 Y 1 E LYS 208 ? CD  ? A LYS 324 CD  
59 1 Y 1 E LYS 208 ? CE  ? A LYS 324 CE  
60 1 Y 1 E LYS 208 ? NZ  ? A LYS 324 NZ  
61 1 Y 1 E MET 209 ? CG  ? A MET 325 CG  
62 1 Y 1 E MET 209 ? SD  ? A MET 325 SD  
63 1 Y 1 E MET 209 ? CE  ? A MET 325 CE  
64 1 Y 1 E MET 242 ? CG  ? A MET 358 CG  
65 1 Y 1 E MET 242 ? SD  ? A MET 358 SD  
66 1 Y 1 E MET 242 ? CE  ? A MET 358 CE  
67 1 Y 1 E HIS 252 ? CG  ? A HIS 368 CG  
68 1 Y 1 E HIS 252 ? ND1 ? A HIS 368 ND1 
69 1 Y 1 E HIS 252 ? CD2 ? A HIS 368 CD2 
70 1 Y 1 E HIS 252 ? CE1 ? A HIS 368 CE1 
71 1 Y 1 E HIS 252 ? NE2 ? A HIS 368 NE2 
72 1 Y 1 E MET 258 ? CG  ? A MET 374 CG  
73 1 Y 1 E MET 258 ? SD  ? A MET 374 SD  
74 1 Y 1 E MET 258 ? CE  ? A MET 374 CE  
75 1 Y 1 E SER 277 ? OG  ? A SER 393 OG  
76 1 Y 1 E PHE 278 ? CG  ? A PHE 394 CG  
77 1 Y 1 E PHE 278 ? CD1 ? A PHE 394 CD1 
78 1 Y 1 E PHE 278 ? CD2 ? A PHE 394 CD2 
79 1 Y 1 E PHE 278 ? CE1 ? A PHE 394 CE1 
80 1 Y 1 E PHE 278 ? CE2 ? A PHE 394 CE2 
81 1 Y 1 E PHE 278 ? CZ  ? A PHE 394 CZ  
82 1 Y 1 E ARG 279 ? CG  ? A ARG 395 CG  
83 1 Y 1 E ARG 279 ? CD  ? A ARG 395 CD  
84 1 Y 1 E ARG 279 ? NE  ? A ARG 395 NE  
85 1 Y 1 E ARG 279 ? CZ  ? A ARG 395 CZ  
86 1 Y 1 E ARG 279 ? NH1 ? A ARG 395 NH1 
87 1 Y 1 E ARG 279 ? NH2 ? A ARG 395 NH2 
88 1 Y 1 E GLN 280 ? CG  ? A GLN 396 CG  
89 1 Y 1 E GLN 280 ? CD  ? A GLN 396 CD  
90 1 Y 1 E GLN 280 ? OE1 ? A GLN 396 OE1 
91 1 Y 1 E GLN 280 ? NE2 ? A GLN 396 NE2 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8KEX 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8KEX 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8KEX 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     8KEX 
_struct.title                        'CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P, local' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8KEX 
_struct_keywords.text            'MRGPRX4, Bile acid, Cholestatic itch, GPCR, Agonist, MEMBRANE PROTEIN' 
_struct_keywords.pdbx_keywords   'MEMBRANE PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP C562_ECOLX  P0ABE7 ? 1 
;ADLEDNMETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLAN
EGKVKEAQAAAEQLKTTRNAYHQKYR
;
23 
2 UNP MRGX4_HUMAN Q96LA9 ? 1 
;MDPTVPVFGTKLTPINGREETPCYNQTLSFTVLTCIISLVGLTGNAVVLWLLGYRMRRNAVSIYILNLAAADFLFLSFQI
IRLPLRLINISHLIRKILVSVMTFPYFTGLSMLSAISTERCLSVLWPIWYRCRRPTHLSAVVCVLLWGLSLLFSMLEWRF
CDFLFSGADSSWCETSDFIPVAWLIFLCVVLCVSSLVLLVRILCGSRKMPLTRLYVTILLTVLVFLLCGLPFGILGALIY
RMHLNLEVLYCHVYLVCMSLSSLNSSANPIIYFFVGSFRQRQNRQNLKLVLQRALQDKPEVDKGEGQLPEESLELSGSRL
GP
;
1  
3 UNP GFP_AEQVI   P42212 ? 1 
;SKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTFSYGVQCFSRYPDHMKQH
DFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGI
KVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGITHGMDE
;
2  
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8KEX E 11  ? 116 ? P0ABE7 23 ? 128 ? -105 0   
2 2 8KEX E 117 ? 438 ? Q96LA9 1  ? 322 ? 1    322 
3 3 8KEX E 449 ? 682 ? P42212 2  ? 235 ? 333  566 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8KEX ASP E 1   ? UNP P0ABE7 ?   ?   'expression tag' -115 1  
1 8KEX TYR E 2   ? UNP P0ABE7 ?   ?   'expression tag' -114 2  
1 8KEX LYS E 3   ? UNP P0ABE7 ?   ?   'expression tag' -113 3  
1 8KEX ASP E 4   ? UNP P0ABE7 ?   ?   'expression tag' -112 4  
1 8KEX ASP E 5   ? UNP P0ABE7 ?   ?   'expression tag' -111 5  
1 8KEX ASP E 6   ? UNP P0ABE7 ?   ?   'expression tag' -110 6  
1 8KEX ASP E 7   ? UNP P0ABE7 ?   ?   'expression tag' -109 7  
1 8KEX LYS E 8   ? UNP P0ABE7 ?   ?   'expression tag' -108 8  
1 8KEX GLU E 9   ? UNP P0ABE7 ?   ?   'expression tag' -107 9  
1 8KEX PHE E 10  ? UNP P0ABE7 ?   ?   'expression tag' -106 10 
1 8KEX TRP E 17  ? UNP P0ABE7 MET 29  conflict         -99  11 
1 8KEX ILE E 112 ? UNP P0ABE7 HIS 124 conflict         -4   12 
1 8KEX LEU E 116 ? UNP P0ABE7 ARG 128 conflict         0    13 
2 8KEX LEU E 439 ? UNP Q96LA9 ?   ?   linker           323  14 
2 8KEX GLU E 440 ? UNP Q96LA9 ?   ?   linker           324  15 
2 8KEX LEU E 441 ? UNP Q96LA9 ?   ?   linker           325  16 
2 8KEX GLU E 442 ? UNP Q96LA9 ?   ?   linker           326  17 
2 8KEX VAL E 443 ? UNP Q96LA9 ?   ?   linker           327  18 
2 8KEX LEU E 444 ? UNP Q96LA9 ?   ?   linker           328  19 
2 8KEX PHE E 445 ? UNP Q96LA9 ?   ?   linker           329  20 
2 8KEX GLN E 446 ? UNP Q96LA9 ?   ?   linker           330  21 
2 8KEX GLY E 447 ? UNP Q96LA9 ?   ?   linker           331  22 
2 8KEX PRO E 448 ? UNP Q96LA9 ?   ?   linker           332  23 
3 8KEX ARG E 477 ? UNP P42212 SER 30  conflict         361  24 
3 8KEX ASN E 486 ? UNP P42212 TYR 39  conflict         370  25 
3 8KEX LEU E 511 ? UNP P42212 PHE 64  conflict         395  26 
3 8KEX THR E 512 ? UNP P42212 SER 65  conflict         396  27 
3 8KEX ARG E 527 ? UNP P42212 GLN 80  conflict         411  28 
3 8KEX SER E 546 ? UNP P42212 PHE 99  conflict         430  29 
3 8KEX THR E 552 ? UNP P42212 ASN 105 conflict         436  30 
3 8KEX PHE E 592 ? UNP P42212 TYR 145 conflict         476  31 
3 8KEX THR E 600 ? UNP P42212 MET 153 conflict         484  32 
3 8KEX ALA E 610 ? UNP P42212 VAL 163 conflict         494  33 
3 8KEX VAL E 618 ? UNP P42212 ILE 171 conflict         502  34 
3 8KEX VAL E 653 ? UNP P42212 ALA 206 conflict         537  35 
3 8KEX TRP E 683 ? UNP P42212 ?   ?   'expression tag' 567  36 
3 8KEX SER E 684 ? UNP P42212 ?   ?   'expression tag' 568  37 
3 8KEX HIS E 685 ? UNP P42212 ?   ?   'expression tag' 569  38 
3 8KEX PRO E 686 ? UNP P42212 ?   ?   'expression tag' 570  39 
3 8KEX GLN E 687 ? UNP P42212 ?   ?   'expression tag' 571  40 
3 8KEX PHE E 688 ? UNP P42212 ?   ?   'expression tag' 572  41 
3 8KEX GLU E 689 ? UNP P42212 ?   ?   'expression tag' 573  42 
3 8KEX LYS E 690 ? UNP P42212 ?   ?   'expression tag' 574  43 
3 8KEX GLY E 691 ? UNP P42212 ?   ?   'expression tag' 575  44 
3 8KEX GLY E 692 ? UNP P42212 ?   ?   'expression tag' 576  45 
3 8KEX GLY E 693 ? UNP P42212 ?   ?   'expression tag' 577  46 
3 8KEX SER E 694 ? UNP P42212 ?   ?   'expression tag' 578  47 
3 8KEX GLY E 695 ? UNP P42212 ?   ?   'expression tag' 579  48 
3 8KEX GLY E 696 ? UNP P42212 ?   ?   'expression tag' 580  49 
3 8KEX GLY E 697 ? UNP P42212 ?   ?   'expression tag' 581  50 
3 8KEX SER E 698 ? UNP P42212 ?   ?   'expression tag' 582  51 
3 8KEX GLY E 699 ? UNP P42212 ?   ?   'expression tag' 583  52 
3 8KEX GLY E 700 ? UNP P42212 ?   ?   'expression tag' 584  53 
3 8KEX SER E 701 ? UNP P42212 ?   ?   'expression tag' 585  54 
3 8KEX ALA E 702 ? UNP P42212 ?   ?   'expression tag' 586  55 
3 8KEX TRP E 703 ? UNP P42212 ?   ?   'expression tag' 587  56 
3 8KEX SER E 704 ? UNP P42212 ?   ?   'expression tag' 588  57 
3 8KEX HIS E 705 ? UNP P42212 ?   ?   'expression tag' 589  58 
3 8KEX PRO E 706 ? UNP P42212 ?   ?   'expression tag' 590  59 
3 8KEX GLN E 707 ? UNP P42212 ?   ?   'expression tag' 591  60 
3 8KEX PHE E 708 ? UNP P42212 ?   ?   'expression tag' 592  61 
3 8KEX GLU E 709 ? UNP P42212 ?   ?   'expression tag' 593  62 
3 8KEX LYS E 710 ? UNP P42212 ?   ?   'expression tag' 594  63 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 143 ? ARG A 171 ? THR E 27  ARG E 55  1 ? 29 
HELX_P HELX_P2  AA2 VAL A 177 ? LEU A 199 ? VAL E 61  LEU E 83  1 ? 23 
HELX_P HELX_P3  AA3 PRO A 200 ? ARG A 202 ? PRO E 84  ARG E 86  5 ? 3  
HELX_P HELX_P4  AA4 LEU A 209 ? TRP A 242 ? LEU E 93  TRP E 126 1 ? 34 
HELX_P HELX_P5  AA5 TRP A 242 ? CYS A 248 ? TRP E 126 CYS E 132 1 ? 7  
HELX_P HELX_P6  AA6 HIS A 253 ? LEU A 268 ? HIS E 137 LEU E 152 1 ? 16 
HELX_P HELX_P7  AA7 PHE A 294 ? CYS A 320 ? PHE E 178 CYS E 204 1 ? 27 
HELX_P HELX_P8  AA8 THR A 328 ? LEU A 343 ? THR E 212 LEU E 227 1 ? 16 
HELX_P HELX_P9  AA9 GLY A 345 ? MET A 358 ? GLY E 229 MET E 242 1 ? 14 
HELX_P HELX_P10 AB1 HIS A 368 ? ARG A 395 ? HIS E 252 ARG E 279 1 ? 28 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            disulf1 
_struct_conn.conn_type_id                  disulf 
_struct_conn.pdbx_leaving_atom_flag        ? 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            139 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           A 
_struct_conn.ptnr2_label_comp_id           CYS 
_struct_conn.ptnr2_label_seq_id            367 
_struct_conn.ptnr2_label_atom_id           SG 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            E 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             23 
_struct_conn.ptnr2_auth_asym_id            E 
_struct_conn.ptnr2_auth_comp_id            CYS 
_struct_conn.ptnr2_auth_seq_id             251 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               2.029 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      CYS 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       139 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      367 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       CYS 
_pdbx_modification_feature.auth_asym_id                       E 
_pdbx_modification_feature.auth_seq_id                        23 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      E 
_pdbx_modification_feature.modified_residue_auth_seq_id       251 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               SG 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                . 
_pdbx_modification_feature.ref_pcm_id                         . 
_pdbx_modification_feature.ref_comp_id                        . 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Disulfide bridge' 
# 
_pdbx_entry_details.entry_id                   8KEX 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   OG 
_pdbx_validate_close_contact.auth_asym_id_1   E 
_pdbx_validate_close_contact.auth_comp_id_1   SER 
_pdbx_validate_close_contact.auth_seq_id_1    100 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   NE1 
_pdbx_validate_close_contact.auth_asym_id_2   E 
_pdbx_validate_close_contact.auth_comp_id_2   TRP 
_pdbx_validate_close_contact.auth_seq_id_2    158 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.17 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 CA E LEU 42 ? ? CB E LEU 42 ? ? CG E LEU 42 ? ? 129.58 115.30 14.28 2.30 N 
2 1 CA E LEU 98 ? ? CB E LEU 98 ? ? CG E LEU 98 ? ? 135.02 115.30 19.72 2.30 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 CYS E 23  ? ? -63.42  -70.40  
2  1 TYR E 24  ? ? -135.11 -40.84  
3  1 ASN E 59  ? ? -73.45  -70.27  
4  1 ALA E 60  ? ? -141.20 -25.10  
5  1 HIS E 92  ? ? 71.45   -0.80   
6  1 PHE E 153 ? ? 58.07   12.75   
7  1 PRO E 210 ? ? -87.68  43.65   
8  1 LEU E 211 ? ? -92.41  46.15   
9  1 LEU E 246 ? ? 72.03   -9.88   
10 1 GLU E 247 ? ? 37.36   -136.69 
# 
_pdbx_validate_peptide_omega.id               1 
_pdbx_validate_peptide_omega.PDB_model_num    1 
_pdbx_validate_peptide_omega.auth_comp_id_1   MET 
_pdbx_validate_peptide_omega.auth_asym_id_1   E 
_pdbx_validate_peptide_omega.auth_seq_id_1    209 
_pdbx_validate_peptide_omega.PDB_ins_code_1   ? 
_pdbx_validate_peptide_omega.label_alt_id_1   ? 
_pdbx_validate_peptide_omega.auth_comp_id_2   PRO 
_pdbx_validate_peptide_omega.auth_asym_id_2   E 
_pdbx_validate_peptide_omega.auth_seq_id_2    210 
_pdbx_validate_peptide_omega.PDB_ins_code_2   ? 
_pdbx_validate_peptide_omega.label_alt_id_2   ? 
_pdbx_validate_peptide_omega.omega            143.71 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8KEX 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    8KEX 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.2 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               451859 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.4 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Cryo-EM structure of MRGPRX4 complex with agonist DCA-3P' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        8KEX 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1100 
_em_imaging.nominal_defocus_max             2200 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              8KEX 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8KEX 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 E ASP -115 ? A ASP 1   
2   1 Y 1 E TYR -114 ? A TYR 2   
3   1 Y 1 E LYS -113 ? A LYS 3   
4   1 Y 1 E ASP -112 ? A ASP 4   
5   1 Y 1 E ASP -111 ? A ASP 5   
6   1 Y 1 E ASP -110 ? A ASP 6   
7   1 Y 1 E ASP -109 ? A ASP 7   
8   1 Y 1 E LYS -108 ? A LYS 8   
9   1 Y 1 E GLU -107 ? A GLU 9   
10  1 Y 1 E PHE -106 ? A PHE 10  
11  1 Y 1 E ALA -105 ? A ALA 11  
12  1 Y 1 E ASP -104 ? A ASP 12  
13  1 Y 1 E LEU -103 ? A LEU 13  
14  1 Y 1 E GLU -102 ? A GLU 14  
15  1 Y 1 E ASP -101 ? A ASP 15  
16  1 Y 1 E ASN -100 ? A ASN 16  
17  1 Y 1 E TRP -99  ? A TRP 17  
18  1 Y 1 E GLU -98  ? A GLU 18  
19  1 Y 1 E THR -97  ? A THR 19  
20  1 Y 1 E LEU -96  ? A LEU 20  
21  1 Y 1 E ASN -95  ? A ASN 21  
22  1 Y 1 E ASP -94  ? A ASP 22  
23  1 Y 1 E ASN -93  ? A ASN 23  
24  1 Y 1 E LEU -92  ? A LEU 24  
25  1 Y 1 E LYS -91  ? A LYS 25  
26  1 Y 1 E VAL -90  ? A VAL 26  
27  1 Y 1 E ILE -89  ? A ILE 27  
28  1 Y 1 E GLU -88  ? A GLU 28  
29  1 Y 1 E LYS -87  ? A LYS 29  
30  1 Y 1 E ALA -86  ? A ALA 30  
31  1 Y 1 E ASP -85  ? A ASP 31  
32  1 Y 1 E ASN -84  ? A ASN 32  
33  1 Y 1 E ALA -83  ? A ALA 33  
34  1 Y 1 E ALA -82  ? A ALA 34  
35  1 Y 1 E GLN -81  ? A GLN 35  
36  1 Y 1 E VAL -80  ? A VAL 36  
37  1 Y 1 E LYS -79  ? A LYS 37  
38  1 Y 1 E ASP -78  ? A ASP 38  
39  1 Y 1 E ALA -77  ? A ALA 39  
40  1 Y 1 E LEU -76  ? A LEU 40  
41  1 Y 1 E THR -75  ? A THR 41  
42  1 Y 1 E LYS -74  ? A LYS 42  
43  1 Y 1 E MET -73  ? A MET 43  
44  1 Y 1 E ARG -72  ? A ARG 44  
45  1 Y 1 E ALA -71  ? A ALA 45  
46  1 Y 1 E ALA -70  ? A ALA 46  
47  1 Y 1 E ALA -69  ? A ALA 47  
48  1 Y 1 E LEU -68  ? A LEU 48  
49  1 Y 1 E ASP -67  ? A ASP 49  
50  1 Y 1 E ALA -66  ? A ALA 50  
51  1 Y 1 E GLN -65  ? A GLN 51  
52  1 Y 1 E LYS -64  ? A LYS 52  
53  1 Y 1 E ALA -63  ? A ALA 53  
54  1 Y 1 E THR -62  ? A THR 54  
55  1 Y 1 E PRO -61  ? A PRO 55  
56  1 Y 1 E PRO -60  ? A PRO 56  
57  1 Y 1 E LYS -59  ? A LYS 57  
58  1 Y 1 E LEU -58  ? A LEU 58  
59  1 Y 1 E GLU -57  ? A GLU 59  
60  1 Y 1 E ASP -56  ? A ASP 60  
61  1 Y 1 E LYS -55  ? A LYS 61  
62  1 Y 1 E SER -54  ? A SER 62  
63  1 Y 1 E PRO -53  ? A PRO 63  
64  1 Y 1 E ASP -52  ? A ASP 64  
65  1 Y 1 E SER -51  ? A SER 65  
66  1 Y 1 E PRO -50  ? A PRO 66  
67  1 Y 1 E GLU -49  ? A GLU 67  
68  1 Y 1 E MET -48  ? A MET 68  
69  1 Y 1 E LYS -47  ? A LYS 69  
70  1 Y 1 E ASP -46  ? A ASP 70  
71  1 Y 1 E PHE -45  ? A PHE 71  
72  1 Y 1 E ARG -44  ? A ARG 72  
73  1 Y 1 E HIS -43  ? A HIS 73  
74  1 Y 1 E GLY -42  ? A GLY 74  
75  1 Y 1 E PHE -41  ? A PHE 75  
76  1 Y 1 E ASP -40  ? A ASP 76  
77  1 Y 1 E ILE -39  ? A ILE 77  
78  1 Y 1 E LEU -38  ? A LEU 78  
79  1 Y 1 E VAL -37  ? A VAL 79  
80  1 Y 1 E GLY -36  ? A GLY 80  
81  1 Y 1 E GLN -35  ? A GLN 81  
82  1 Y 1 E ILE -34  ? A ILE 82  
83  1 Y 1 E ASP -33  ? A ASP 83  
84  1 Y 1 E ASP -32  ? A ASP 84  
85  1 Y 1 E ALA -31  ? A ALA 85  
86  1 Y 1 E LEU -30  ? A LEU 86  
87  1 Y 1 E LYS -29  ? A LYS 87  
88  1 Y 1 E LEU -28  ? A LEU 88  
89  1 Y 1 E ALA -27  ? A ALA 89  
90  1 Y 1 E ASN -26  ? A ASN 90  
91  1 Y 1 E GLU -25  ? A GLU 91  
92  1 Y 1 E GLY -24  ? A GLY 92  
93  1 Y 1 E LYS -23  ? A LYS 93  
94  1 Y 1 E VAL -22  ? A VAL 94  
95  1 Y 1 E LYS -21  ? A LYS 95  
96  1 Y 1 E GLU -20  ? A GLU 96  
97  1 Y 1 E ALA -19  ? A ALA 97  
98  1 Y 1 E GLN -18  ? A GLN 98  
99  1 Y 1 E ALA -17  ? A ALA 99  
100 1 Y 1 E ALA -16  ? A ALA 100 
101 1 Y 1 E ALA -15  ? A ALA 101 
102 1 Y 1 E GLU -14  ? A GLU 102 
103 1 Y 1 E GLN -13  ? A GLN 103 
104 1 Y 1 E LEU -12  ? A LEU 104 
105 1 Y 1 E LYS -11  ? A LYS 105 
106 1 Y 1 E THR -10  ? A THR 106 
107 1 Y 1 E THR -9   ? A THR 107 
108 1 Y 1 E ARG -8   ? A ARG 108 
109 1 Y 1 E ASN -7   ? A ASN 109 
110 1 Y 1 E ALA -6   ? A ALA 110 
111 1 Y 1 E TYR -5   ? A TYR 111 
112 1 Y 1 E ILE -4   ? A ILE 112 
113 1 Y 1 E GLN -3   ? A GLN 113 
114 1 Y 1 E LYS -2   ? A LYS 114 
115 1 Y 1 E TYR -1   ? A TYR 115 
116 1 Y 1 E LEU 0    ? A LEU 116 
117 1 Y 1 E MET 1    ? A MET 117 
118 1 Y 1 E ASP 2    ? A ASP 118 
119 1 Y 1 E PRO 3    ? A PRO 119 
120 1 Y 1 E THR 4    ? A THR 120 
121 1 Y 1 E VAL 5    ? A VAL 121 
122 1 Y 1 E PRO 6    ? A PRO 122 
123 1 Y 1 E VAL 7    ? A VAL 123 
124 1 Y 1 E PHE 8    ? A PHE 124 
125 1 Y 1 E GLY 9    ? A GLY 125 
126 1 Y 1 E THR 10   ? A THR 126 
127 1 Y 1 E LYS 11   ? A LYS 127 
128 1 Y 1 E LEU 12   ? A LEU 128 
129 1 Y 1 E THR 13   ? A THR 129 
130 1 Y 1 E PRO 14   ? A PRO 130 
131 1 Y 1 E ILE 15   ? A ILE 131 
132 1 Y 1 E ASN 16   ? A ASN 132 
133 1 Y 1 E GLY 17   ? A GLY 133 
134 1 Y 1 E ARG 18   ? A ARG 134 
135 1 Y 1 E GLU 19   ? A GLU 135 
136 1 Y 1 E GLU 20   ? A GLU 136 
137 1 Y 1 E THR 21   ? A THR 137 
138 1 Y 1 E SER 166  ? A SER 282 
139 1 Y 1 E GLY 167  ? A GLY 283 
140 1 Y 1 E ALA 168  ? A ALA 284 
141 1 Y 1 E ASP 169  ? A ASP 285 
142 1 Y 1 E ARG 281  ? A ARG 397 
143 1 Y 1 E GLN 282  ? A GLN 398 
144 1 Y 1 E ASN 283  ? A ASN 399 
145 1 Y 1 E ARG 284  ? A ARG 400 
146 1 Y 1 E GLN 285  ? A GLN 401 
147 1 Y 1 E ASN 286  ? A ASN 402 
148 1 Y 1 E LEU 287  ? A LEU 403 
149 1 Y 1 E LYS 288  ? A LYS 404 
150 1 Y 1 E LEU 289  ? A LEU 405 
151 1 Y 1 E VAL 290  ? A VAL 406 
152 1 Y 1 E LEU 291  ? A LEU 407 
153 1 Y 1 E GLN 292  ? A GLN 408 
154 1 Y 1 E ARG 293  ? A ARG 409 
155 1 Y 1 E ALA 294  ? A ALA 410 
156 1 Y 1 E LEU 295  ? A LEU 411 
157 1 Y 1 E GLN 296  ? A GLN 412 
158 1 Y 1 E ASP 297  ? A ASP 413 
159 1 Y 1 E LYS 298  ? A LYS 414 
160 1 Y 1 E PRO 299  ? A PRO 415 
161 1 Y 1 E GLU 300  ? A GLU 416 
162 1 Y 1 E VAL 301  ? A VAL 417 
163 1 Y 1 E ASP 302  ? A ASP 418 
164 1 Y 1 E LYS 303  ? A LYS 419 
165 1 Y 1 E GLY 304  ? A GLY 420 
166 1 Y 1 E GLU 305  ? A GLU 421 
167 1 Y 1 E GLY 306  ? A GLY 422 
168 1 Y 1 E GLN 307  ? A GLN 423 
169 1 Y 1 E LEU 308  ? A LEU 424 
170 1 Y 1 E PRO 309  ? A PRO 425 
171 1 Y 1 E GLU 310  ? A GLU 426 
172 1 Y 1 E GLU 311  ? A GLU 427 
173 1 Y 1 E SER 312  ? A SER 428 
174 1 Y 1 E LEU 313  ? A LEU 429 
175 1 Y 1 E GLU 314  ? A GLU 430 
176 1 Y 1 E LEU 315  ? A LEU 431 
177 1 Y 1 E SER 316  ? A SER 432 
178 1 Y 1 E GLY 317  ? A GLY 433 
179 1 Y 1 E SER 318  ? A SER 434 
180 1 Y 1 E ARG 319  ? A ARG 435 
181 1 Y 1 E LEU 320  ? A LEU 436 
182 1 Y 1 E GLY 321  ? A GLY 437 
183 1 Y 1 E PRO 322  ? A PRO 438 
184 1 Y 1 E LEU 323  ? A LEU 439 
185 1 Y 1 E GLU 324  ? A GLU 440 
186 1 Y 1 E LEU 325  ? A LEU 441 
187 1 Y 1 E GLU 326  ? A GLU 442 
188 1 Y 1 E VAL 327  ? A VAL 443 
189 1 Y 1 E LEU 328  ? A LEU 444 
190 1 Y 1 E PHE 329  ? A PHE 445 
191 1 Y 1 E GLN 330  ? A GLN 446 
192 1 Y 1 E GLY 331  ? A GLY 447 
193 1 Y 1 E PRO 332  ? A PRO 448 
194 1 Y 1 E SER 333  ? A SER 449 
195 1 Y 1 E LYS 334  ? A LYS 450 
196 1 Y 1 E GLY 335  ? A GLY 451 
197 1 Y 1 E GLU 336  ? A GLU 452 
198 1 Y 1 E GLU 337  ? A GLU 453 
199 1 Y 1 E LEU 338  ? A LEU 454 
200 1 Y 1 E PHE 339  ? A PHE 455 
201 1 Y 1 E THR 340  ? A THR 456 
202 1 Y 1 E GLY 341  ? A GLY 457 
203 1 Y 1 E VAL 342  ? A VAL 458 
204 1 Y 1 E VAL 343  ? A VAL 459 
205 1 Y 1 E PRO 344  ? A PRO 460 
206 1 Y 1 E ILE 345  ? A ILE 461 
207 1 Y 1 E LEU 346  ? A LEU 462 
208 1 Y 1 E VAL 347  ? A VAL 463 
209 1 Y 1 E GLU 348  ? A GLU 464 
210 1 Y 1 E LEU 349  ? A LEU 465 
211 1 Y 1 E ASP 350  ? A ASP 466 
212 1 Y 1 E GLY 351  ? A GLY 467 
213 1 Y 1 E ASP 352  ? A ASP 468 
214 1 Y 1 E VAL 353  ? A VAL 469 
215 1 Y 1 E ASN 354  ? A ASN 470 
216 1 Y 1 E GLY 355  ? A GLY 471 
217 1 Y 1 E HIS 356  ? A HIS 472 
218 1 Y 1 E LYS 357  ? A LYS 473 
219 1 Y 1 E PHE 358  ? A PHE 474 
220 1 Y 1 E SER 359  ? A SER 475 
221 1 Y 1 E VAL 360  ? A VAL 476 
222 1 Y 1 E ARG 361  ? A ARG 477 
223 1 Y 1 E GLY 362  ? A GLY 478 
224 1 Y 1 E GLU 363  ? A GLU 479 
225 1 Y 1 E GLY 364  ? A GLY 480 
226 1 Y 1 E GLU 365  ? A GLU 481 
227 1 Y 1 E GLY 366  ? A GLY 482 
228 1 Y 1 E ASP 367  ? A ASP 483 
229 1 Y 1 E ALA 368  ? A ALA 484 
230 1 Y 1 E THR 369  ? A THR 485 
231 1 Y 1 E ASN 370  ? A ASN 486 
232 1 Y 1 E GLY 371  ? A GLY 487 
233 1 Y 1 E LYS 372  ? A LYS 488 
234 1 Y 1 E LEU 373  ? A LEU 489 
235 1 Y 1 E THR 374  ? A THR 490 
236 1 Y 1 E LEU 375  ? A LEU 491 
237 1 Y 1 E LYS 376  ? A LYS 492 
238 1 Y 1 E PHE 377  ? A PHE 493 
239 1 Y 1 E ILE 378  ? A ILE 494 
240 1 Y 1 E CYS 379  ? A CYS 495 
241 1 Y 1 E THR 380  ? A THR 496 
242 1 Y 1 E THR 381  ? A THR 497 
243 1 Y 1 E GLY 382  ? A GLY 498 
244 1 Y 1 E LYS 383  ? A LYS 499 
245 1 Y 1 E LEU 384  ? A LEU 500 
246 1 Y 1 E PRO 385  ? A PRO 501 
247 1 Y 1 E VAL 386  ? A VAL 502 
248 1 Y 1 E PRO 387  ? A PRO 503 
249 1 Y 1 E TRP 388  ? A TRP 504 
250 1 Y 1 E PRO 389  ? A PRO 505 
251 1 Y 1 E THR 390  ? A THR 506 
252 1 Y 1 E LEU 391  ? A LEU 507 
253 1 Y 1 E VAL 392  ? A VAL 508 
254 1 Y 1 E THR 393  ? A THR 509 
255 1 Y 1 E THR 394  ? A THR 510 
256 1 Y 1 E LEU 395  ? A LEU 511 
257 1 Y 1 E THR 396  ? A THR 512 
258 1 Y 1 E TYR 397  ? A TYR 513 
259 1 Y 1 E GLY 398  ? A GLY 514 
260 1 Y 1 E VAL 399  ? A VAL 515 
261 1 Y 1 E GLN 400  ? A GLN 516 
262 1 Y 1 E CYS 401  ? A CYS 517 
263 1 Y 1 E PHE 402  ? A PHE 518 
264 1 Y 1 E SER 403  ? A SER 519 
265 1 Y 1 E ARG 404  ? A ARG 520 
266 1 Y 1 E TYR 405  ? A TYR 521 
267 1 Y 1 E PRO 406  ? A PRO 522 
268 1 Y 1 E ASP 407  ? A ASP 523 
269 1 Y 1 E HIS 408  ? A HIS 524 
270 1 Y 1 E MET 409  ? A MET 525 
271 1 Y 1 E LYS 410  ? A LYS 526 
272 1 Y 1 E ARG 411  ? A ARG 527 
273 1 Y 1 E HIS 412  ? A HIS 528 
274 1 Y 1 E ASP 413  ? A ASP 529 
275 1 Y 1 E PHE 414  ? A PHE 530 
276 1 Y 1 E PHE 415  ? A PHE 531 
277 1 Y 1 E LYS 416  ? A LYS 532 
278 1 Y 1 E SER 417  ? A SER 533 
279 1 Y 1 E ALA 418  ? A ALA 534 
280 1 Y 1 E MET 419  ? A MET 535 
281 1 Y 1 E PRO 420  ? A PRO 536 
282 1 Y 1 E GLU 421  ? A GLU 537 
283 1 Y 1 E GLY 422  ? A GLY 538 
284 1 Y 1 E TYR 423  ? A TYR 539 
285 1 Y 1 E VAL 424  ? A VAL 540 
286 1 Y 1 E GLN 425  ? A GLN 541 
287 1 Y 1 E GLU 426  ? A GLU 542 
288 1 Y 1 E ARG 427  ? A ARG 543 
289 1 Y 1 E THR 428  ? A THR 544 
290 1 Y 1 E ILE 429  ? A ILE 545 
291 1 Y 1 E SER 430  ? A SER 546 
292 1 Y 1 E PHE 431  ? A PHE 547 
293 1 Y 1 E LYS 432  ? A LYS 548 
294 1 Y 1 E ASP 433  ? A ASP 549 
295 1 Y 1 E ASP 434  ? A ASP 550 
296 1 Y 1 E GLY 435  ? A GLY 551 
297 1 Y 1 E THR 436  ? A THR 552 
298 1 Y 1 E TYR 437  ? A TYR 553 
299 1 Y 1 E LYS 438  ? A LYS 554 
300 1 Y 1 E THR 439  ? A THR 555 
301 1 Y 1 E ARG 440  ? A ARG 556 
302 1 Y 1 E ALA 441  ? A ALA 557 
303 1 Y 1 E GLU 442  ? A GLU 558 
304 1 Y 1 E VAL 443  ? A VAL 559 
305 1 Y 1 E LYS 444  ? A LYS 560 
306 1 Y 1 E PHE 445  ? A PHE 561 
307 1 Y 1 E GLU 446  ? A GLU 562 
308 1 Y 1 E GLY 447  ? A GLY 563 
309 1 Y 1 E ASP 448  ? A ASP 564 
310 1 Y 1 E THR 449  ? A THR 565 
311 1 Y 1 E LEU 450  ? A LEU 566 
312 1 Y 1 E VAL 451  ? A VAL 567 
313 1 Y 1 E ASN 452  ? A ASN 568 
314 1 Y 1 E ARG 453  ? A ARG 569 
315 1 Y 1 E ILE 454  ? A ILE 570 
316 1 Y 1 E GLU 455  ? A GLU 571 
317 1 Y 1 E LEU 456  ? A LEU 572 
318 1 Y 1 E LYS 457  ? A LYS 573 
319 1 Y 1 E GLY 458  ? A GLY 574 
320 1 Y 1 E ILE 459  ? A ILE 575 
321 1 Y 1 E ASP 460  ? A ASP 576 
322 1 Y 1 E PHE 461  ? A PHE 577 
323 1 Y 1 E LYS 462  ? A LYS 578 
324 1 Y 1 E GLU 463  ? A GLU 579 
325 1 Y 1 E ASP 464  ? A ASP 580 
326 1 Y 1 E GLY 465  ? A GLY 581 
327 1 Y 1 E ASN 466  ? A ASN 582 
328 1 Y 1 E ILE 467  ? A ILE 583 
329 1 Y 1 E LEU 468  ? A LEU 584 
330 1 Y 1 E GLY 469  ? A GLY 585 
331 1 Y 1 E HIS 470  ? A HIS 586 
332 1 Y 1 E LYS 471  ? A LYS 587 
333 1 Y 1 E LEU 472  ? A LEU 588 
334 1 Y 1 E GLU 473  ? A GLU 589 
335 1 Y 1 E TYR 474  ? A TYR 590 
336 1 Y 1 E ASN 475  ? A ASN 591 
337 1 Y 1 E PHE 476  ? A PHE 592 
338 1 Y 1 E ASN 477  ? A ASN 593 
339 1 Y 1 E SER 478  ? A SER 594 
340 1 Y 1 E HIS 479  ? A HIS 595 
341 1 Y 1 E ASN 480  ? A ASN 596 
342 1 Y 1 E VAL 481  ? A VAL 597 
343 1 Y 1 E TYR 482  ? A TYR 598 
344 1 Y 1 E ILE 483  ? A ILE 599 
345 1 Y 1 E THR 484  ? A THR 600 
346 1 Y 1 E ALA 485  ? A ALA 601 
347 1 Y 1 E ASP 486  ? A ASP 602 
348 1 Y 1 E LYS 487  ? A LYS 603 
349 1 Y 1 E GLN 488  ? A GLN 604 
350 1 Y 1 E LYS 489  ? A LYS 605 
351 1 Y 1 E ASN 490  ? A ASN 606 
352 1 Y 1 E GLY 491  ? A GLY 607 
353 1 Y 1 E ILE 492  ? A ILE 608 
354 1 Y 1 E LYS 493  ? A LYS 609 
355 1 Y 1 E ALA 494  ? A ALA 610 
356 1 Y 1 E ASN 495  ? A ASN 611 
357 1 Y 1 E PHE 496  ? A PHE 612 
358 1 Y 1 E LYS 497  ? A LYS 613 
359 1 Y 1 E ILE 498  ? A ILE 614 
360 1 Y 1 E ARG 499  ? A ARG 615 
361 1 Y 1 E HIS 500  ? A HIS 616 
362 1 Y 1 E ASN 501  ? A ASN 617 
363 1 Y 1 E VAL 502  ? A VAL 618 
364 1 Y 1 E GLU 503  ? A GLU 619 
365 1 Y 1 E ASP 504  ? A ASP 620 
366 1 Y 1 E GLY 505  ? A GLY 621 
367 1 Y 1 E SER 506  ? A SER 622 
368 1 Y 1 E VAL 507  ? A VAL 623 
369 1 Y 1 E GLN 508  ? A GLN 624 
370 1 Y 1 E LEU 509  ? A LEU 625 
371 1 Y 1 E ALA 510  ? A ALA 626 
372 1 Y 1 E ASP 511  ? A ASP 627 
373 1 Y 1 E HIS 512  ? A HIS 628 
374 1 Y 1 E TYR 513  ? A TYR 629 
375 1 Y 1 E GLN 514  ? A GLN 630 
376 1 Y 1 E GLN 515  ? A GLN 631 
377 1 Y 1 E ASN 516  ? A ASN 632 
378 1 Y 1 E THR 517  ? A THR 633 
379 1 Y 1 E PRO 518  ? A PRO 634 
380 1 Y 1 E ILE 519  ? A ILE 635 
381 1 Y 1 E GLY 520  ? A GLY 636 
382 1 Y 1 E ASP 521  ? A ASP 637 
383 1 Y 1 E GLY 522  ? A GLY 638 
384 1 Y 1 E PRO 523  ? A PRO 639 
385 1 Y 1 E VAL 524  ? A VAL 640 
386 1 Y 1 E LEU 525  ? A LEU 641 
387 1 Y 1 E LEU 526  ? A LEU 642 
388 1 Y 1 E PRO 527  ? A PRO 643 
389 1 Y 1 E ASP 528  ? A ASP 644 
390 1 Y 1 E ASN 529  ? A ASN 645 
391 1 Y 1 E HIS 530  ? A HIS 646 
392 1 Y 1 E TYR 531  ? A TYR 647 
393 1 Y 1 E LEU 532  ? A LEU 648 
394 1 Y 1 E SER 533  ? A SER 649 
395 1 Y 1 E THR 534  ? A THR 650 
396 1 Y 1 E GLN 535  ? A GLN 651 
397 1 Y 1 E SER 536  ? A SER 652 
398 1 Y 1 E VAL 537  ? A VAL 653 
399 1 Y 1 E LEU 538  ? A LEU 654 
400 1 Y 1 E SER 539  ? A SER 655 
401 1 Y 1 E LYS 540  ? A LYS 656 
402 1 Y 1 E ASP 541  ? A ASP 657 
403 1 Y 1 E PRO 542  ? A PRO 658 
404 1 Y 1 E ASN 543  ? A ASN 659 
405 1 Y 1 E GLU 544  ? A GLU 660 
406 1 Y 1 E LYS 545  ? A LYS 661 
407 1 Y 1 E ARG 546  ? A ARG 662 
408 1 Y 1 E ASP 547  ? A ASP 663 
409 1 Y 1 E HIS 548  ? A HIS 664 
410 1 Y 1 E MET 549  ? A MET 665 
411 1 Y 1 E VAL 550  ? A VAL 666 
412 1 Y 1 E LEU 551  ? A LEU 667 
413 1 Y 1 E LEU 552  ? A LEU 668 
414 1 Y 1 E GLU 553  ? A GLU 669 
415 1 Y 1 E PHE 554  ? A PHE 670 
416 1 Y 1 E VAL 555  ? A VAL 671 
417 1 Y 1 E THR 556  ? A THR 672 
418 1 Y 1 E ALA 557  ? A ALA 673 
419 1 Y 1 E ALA 558  ? A ALA 674 
420 1 Y 1 E GLY 559  ? A GLY 675 
421 1 Y 1 E ILE 560  ? A ILE 676 
422 1 Y 1 E THR 561  ? A THR 677 
423 1 Y 1 E HIS 562  ? A HIS 678 
424 1 Y 1 E GLY 563  ? A GLY 679 
425 1 Y 1 E MET 564  ? A MET 680 
426 1 Y 1 E ASP 565  ? A ASP 681 
427 1 Y 1 E GLU 566  ? A GLU 682 
428 1 Y 1 E TRP 567  ? A TRP 683 
429 1 Y 1 E SER 568  ? A SER 684 
430 1 Y 1 E HIS 569  ? A HIS 685 
431 1 Y 1 E PRO 570  ? A PRO 686 
432 1 Y 1 E GLN 571  ? A GLN 687 
433 1 Y 1 E PHE 572  ? A PHE 688 
434 1 Y 1 E GLU 573  ? A GLU 689 
435 1 Y 1 E LYS 574  ? A LYS 690 
436 1 Y 1 E GLY 575  ? A GLY 691 
437 1 Y 1 E GLY 576  ? A GLY 692 
438 1 Y 1 E GLY 577  ? A GLY 693 
439 1 Y 1 E SER 578  ? A SER 694 
440 1 Y 1 E GLY 579  ? A GLY 695 
441 1 Y 1 E GLY 580  ? A GLY 696 
442 1 Y 1 E GLY 581  ? A GLY 697 
443 1 Y 1 E SER 582  ? A SER 698 
444 1 Y 1 E GLY 583  ? A GLY 699 
445 1 Y 1 E GLY 584  ? A GLY 700 
446 1 Y 1 E SER 585  ? A SER 701 
447 1 Y 1 E ALA 586  ? A ALA 702 
448 1 Y 1 E TRP 587  ? A TRP 703 
449 1 Y 1 E SER 588  ? A SER 704 
450 1 Y 1 E HIS 589  ? A HIS 705 
451 1 Y 1 E PRO 590  ? A PRO 706 
452 1 Y 1 E GLN 591  ? A GLN 707 
453 1 Y 1 E PHE 592  ? A PHE 708 
454 1 Y 1 E GLU 593  ? A GLU 709 
455 1 Y 1 E LYS 594  ? A LYS 710 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
JW0 C1   C N N 180 
JW0 C2   C N R 181 
JW0 C3   C N N 182 
JW0 O3   O N N 183 
JW0 C4   C N R 184 
JW0 C5   C N S 185 
JW0 O5   O N N 186 
JW0 C6   C N N 187 
JW0 C10  C N S 188 
JW0 C11  C N S 189 
JW0 C12  C N R 190 
JW0 C13  C N S 191 
JW0 C14  C N N 192 
JW0 C15  C N N 193 
JW0 C16  C N N 194 
JW0 C17  C N R 195 
JW0 C18  C N R 196 
JW0 C19  C N N 197 
JW0 C20  C N N 198 
JW0 C21  C N N 199 
JW0 C22  C N N 200 
JW0 C23  C N N 201 
JW0 C24  C N N 202 
JW0 C7   C N N 203 
JW0 C8   C N N 204 
JW0 C9   C N R 205 
JW0 O1   O N N 206 
JW0 O2   O N N 207 
JW0 O4   O N N 208 
JW0 O6   O N N 209 
JW0 O7   O N N 210 
JW0 P1   P N N 211 
JW0 H1   H N N 212 
JW0 H2   H N N 213 
JW0 H3   H N N 214 
JW0 H4   H N N 215 
JW0 H5   H N N 216 
JW0 H6   H N N 217 
JW0 H7   H N N 218 
JW0 H8   H N N 219 
JW0 H9   H N N 220 
JW0 H10  H N N 221 
JW0 H11  H N N 222 
JW0 H12  H N N 223 
JW0 H13  H N N 224 
JW0 H14  H N N 225 
JW0 H15  H N N 226 
JW0 H16  H N N 227 
JW0 H17  H N N 228 
JW0 H18  H N N 229 
JW0 H19  H N N 230 
JW0 H20  H N N 231 
JW0 H21  H N N 232 
JW0 H22  H N N 233 
JW0 H23  H N N 234 
JW0 H24  H N N 235 
JW0 H25  H N N 236 
JW0 H26  H N N 237 
JW0 H27  H N N 238 
JW0 H28  H N N 239 
JW0 H29  H N N 240 
JW0 H30  H N N 241 
JW0 H31  H N N 242 
JW0 H32  H N N 243 
JW0 H33  H N N 244 
JW0 H34  H N N 245 
JW0 H35  H N N 246 
JW0 H36  H N N 247 
JW0 H37  H N N 248 
JW0 H38  H N N 249 
JW0 H39  H N N 250 
JW0 H40  H N N 251 
JW0 H41  H N N 252 
LEU N    N N N 253 
LEU CA   C N S 254 
LEU C    C N N 255 
LEU O    O N N 256 
LEU CB   C N N 257 
LEU CG   C N N 258 
LEU CD1  C N N 259 
LEU CD2  C N N 260 
LEU OXT  O N N 261 
LEU H    H N N 262 
LEU H2   H N N 263 
LEU HA   H N N 264 
LEU HB2  H N N 265 
LEU HB3  H N N 266 
LEU HG   H N N 267 
LEU HD11 H N N 268 
LEU HD12 H N N 269 
LEU HD13 H N N 270 
LEU HD21 H N N 271 
LEU HD22 H N N 272 
LEU HD23 H N N 273 
LEU HXT  H N N 274 
LYS N    N N N 275 
LYS CA   C N S 276 
LYS C    C N N 277 
LYS O    O N N 278 
LYS CB   C N N 279 
LYS CG   C N N 280 
LYS CD   C N N 281 
LYS CE   C N N 282 
LYS NZ   N N N 283 
LYS OXT  O N N 284 
LYS H    H N N 285 
LYS H2   H N N 286 
LYS HA   H N N 287 
LYS HB2  H N N 288 
LYS HB3  H N N 289 
LYS HG2  H N N 290 
LYS HG3  H N N 291 
LYS HD2  H N N 292 
LYS HD3  H N N 293 
LYS HE2  H N N 294 
LYS HE3  H N N 295 
LYS HZ1  H N N 296 
LYS HZ2  H N N 297 
LYS HZ3  H N N 298 
LYS HXT  H N N 299 
MET N    N N N 300 
MET CA   C N S 301 
MET C    C N N 302 
MET O    O N N 303 
MET CB   C N N 304 
MET CG   C N N 305 
MET SD   S N N 306 
MET CE   C N N 307 
MET OXT  O N N 308 
MET H    H N N 309 
MET H2   H N N 310 
MET HA   H N N 311 
MET HB2  H N N 312 
MET HB3  H N N 313 
MET HG2  H N N 314 
MET HG3  H N N 315 
MET HE1  H N N 316 
MET HE2  H N N 317 
MET HE3  H N N 318 
MET HXT  H N N 319 
PHE N    N N N 320 
PHE CA   C N S 321 
PHE C    C N N 322 
PHE O    O N N 323 
PHE CB   C N N 324 
PHE CG   C Y N 325 
PHE CD1  C Y N 326 
PHE CD2  C Y N 327 
PHE CE1  C Y N 328 
PHE CE2  C Y N 329 
PHE CZ   C Y N 330 
PHE OXT  O N N 331 
PHE H    H N N 332 
PHE H2   H N N 333 
PHE HA   H N N 334 
PHE HB2  H N N 335 
PHE HB3  H N N 336 
PHE HD1  H N N 337 
PHE HD2  H N N 338 
PHE HE1  H N N 339 
PHE HE2  H N N 340 
PHE HZ   H N N 341 
PHE HXT  H N N 342 
PRO N    N N N 343 
PRO CA   C N S 344 
PRO C    C N N 345 
PRO O    O N N 346 
PRO CB   C N N 347 
PRO CG   C N N 348 
PRO CD   C N N 349 
PRO OXT  O N N 350 
PRO H    H N N 351 
PRO HA   H N N 352 
PRO HB2  H N N 353 
PRO HB3  H N N 354 
PRO HG2  H N N 355 
PRO HG3  H N N 356 
PRO HD2  H N N 357 
PRO HD3  H N N 358 
PRO HXT  H N N 359 
SER N    N N N 360 
SER CA   C N S 361 
SER C    C N N 362 
SER O    O N N 363 
SER CB   C N N 364 
SER OG   O N N 365 
SER OXT  O N N 366 
SER H    H N N 367 
SER H2   H N N 368 
SER HA   H N N 369 
SER HB2  H N N 370 
SER HB3  H N N 371 
SER HG   H N N 372 
SER HXT  H N N 373 
THR N    N N N 374 
THR CA   C N S 375 
THR C    C N N 376 
THR O    O N N 377 
THR CB   C N R 378 
THR OG1  O N N 379 
THR CG2  C N N 380 
THR OXT  O N N 381 
THR H    H N N 382 
THR H2   H N N 383 
THR HA   H N N 384 
THR HB   H N N 385 
THR HG1  H N N 386 
THR HG21 H N N 387 
THR HG22 H N N 388 
THR HG23 H N N 389 
THR HXT  H N N 390 
TRP N    N N N 391 
TRP CA   C N S 392 
TRP C    C N N 393 
TRP O    O N N 394 
TRP CB   C N N 395 
TRP CG   C Y N 396 
TRP CD1  C Y N 397 
TRP CD2  C Y N 398 
TRP NE1  N Y N 399 
TRP CE2  C Y N 400 
TRP CE3  C Y N 401 
TRP CZ2  C Y N 402 
TRP CZ3  C Y N 403 
TRP CH2  C Y N 404 
TRP OXT  O N N 405 
TRP H    H N N 406 
TRP H2   H N N 407 
TRP HA   H N N 408 
TRP HB2  H N N 409 
TRP HB3  H N N 410 
TRP HD1  H N N 411 
TRP HE1  H N N 412 
TRP HE3  H N N 413 
TRP HZ2  H N N 414 
TRP HZ3  H N N 415 
TRP HH2  H N N 416 
TRP HXT  H N N 417 
TYR N    N N N 418 
TYR CA   C N S 419 
TYR C    C N N 420 
TYR O    O N N 421 
TYR CB   C N N 422 
TYR CG   C Y N 423 
TYR CD1  C Y N 424 
TYR CD2  C Y N 425 
TYR CE1  C Y N 426 
TYR CE2  C Y N 427 
TYR CZ   C Y N 428 
TYR OH   O N N 429 
TYR OXT  O N N 430 
TYR H    H N N 431 
TYR H2   H N N 432 
TYR HA   H N N 433 
TYR HB2  H N N 434 
TYR HB3  H N N 435 
TYR HD1  H N N 436 
TYR HD2  H N N 437 
TYR HE1  H N N 438 
TYR HE2  H N N 439 
TYR HH   H N N 440 
TYR HXT  H N N 441 
VAL N    N N N 442 
VAL CA   C N S 443 
VAL C    C N N 444 
VAL O    O N N 445 
VAL CB   C N N 446 
VAL CG1  C N N 447 
VAL CG2  C N N 448 
VAL OXT  O N N 449 
VAL H    H N N 450 
VAL H2   H N N 451 
VAL HA   H N N 452 
VAL HB   H N N 453 
VAL HG11 H N N 454 
VAL HG12 H N N 455 
VAL HG13 H N N 456 
VAL HG21 H N N 457 
VAL HG22 H N N 458 
VAL HG23 H N N 459 
VAL HXT  H N N 460 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
JW0 C23 C5   sing N N 171 
JW0 C1  C6   sing N N 172 
JW0 C1  C2   sing N N 173 
JW0 O5  P1   doub N N 174 
JW0 C6  C5   sing N N 175 
JW0 O1  C13  sing N N 176 
JW0 C14 C13  sing N N 177 
JW0 C14 C10  sing N N 178 
JW0 C5  C10  sing N N 179 
JW0 C5  C4   sing N N 180 
JW0 C2  C3   sing N N 181 
JW0 C2  O4   sing N N 182 
JW0 C13 C12  sing N N 183 
JW0 C10 C9   sing N N 184 
JW0 P1  O7   sing N N 185 
JW0 P1  O4   sing N N 186 
JW0 P1  O6   sing N N 187 
JW0 C3  C4   sing N N 188 
JW0 C21 C18  sing N N 189 
JW0 C4  C7   sing N N 190 
JW0 C18 C17  sing N N 191 
JW0 C18 C19  sing N N 192 
JW0 C12 C17  sing N N 193 
JW0 C12 C11  sing N N 194 
JW0 C12 C22  sing N N 195 
JW0 C17 C16  sing N N 196 
JW0 C9  C11  sing N N 197 
JW0 C9  C8   sing N N 198 
JW0 C11 C15  sing N N 199 
JW0 C7  C8   sing N N 200 
JW0 C20 C19  sing N N 201 
JW0 C20 C24  sing N N 202 
JW0 O2  C24  doub N N 203 
JW0 C24 O3   sing N N 204 
JW0 C16 C15  sing N N 205 
JW0 C1  H1   sing N N 206 
JW0 C1  H2   sing N N 207 
JW0 C2  H3   sing N N 208 
JW0 C3  H4   sing N N 209 
JW0 C3  H5   sing N N 210 
JW0 O3  H6   sing N N 211 
JW0 C4  H7   sing N N 212 
JW0 C6  H8   sing N N 213 
JW0 C6  H9   sing N N 214 
JW0 C10 H10  sing N N 215 
JW0 C11 H11  sing N N 216 
JW0 C13 H12  sing N N 217 
JW0 C14 H13  sing N N 218 
JW0 C14 H14  sing N N 219 
JW0 C15 H15  sing N N 220 
JW0 C15 H16  sing N N 221 
JW0 C16 H17  sing N N 222 
JW0 C16 H18  sing N N 223 
JW0 C17 H19  sing N N 224 
JW0 C18 H20  sing N N 225 
JW0 C19 H21  sing N N 226 
JW0 C19 H22  sing N N 227 
JW0 C20 H23  sing N N 228 
JW0 C20 H24  sing N N 229 
JW0 C21 H25  sing N N 230 
JW0 C21 H26  sing N N 231 
JW0 C21 H27  sing N N 232 
JW0 C22 H28  sing N N 233 
JW0 C22 H29  sing N N 234 
JW0 C22 H30  sing N N 235 
JW0 C23 H31  sing N N 236 
JW0 C23 H32  sing N N 237 
JW0 C23 H33  sing N N 238 
JW0 C7  H34  sing N N 239 
JW0 C7  H35  sing N N 240 
JW0 C8  H36  sing N N 241 
JW0 C8  H37  sing N N 242 
JW0 C9  H38  sing N N 243 
JW0 O1  H39  sing N N 244 
JW0 O6  H40  sing N N 245 
JW0 O7  H41  sing N N 246 
LEU N   CA   sing N N 247 
LEU N   H    sing N N 248 
LEU N   H2   sing N N 249 
LEU CA  C    sing N N 250 
LEU CA  CB   sing N N 251 
LEU CA  HA   sing N N 252 
LEU C   O    doub N N 253 
LEU C   OXT  sing N N 254 
LEU CB  CG   sing N N 255 
LEU CB  HB2  sing N N 256 
LEU CB  HB3  sing N N 257 
LEU CG  CD1  sing N N 258 
LEU CG  CD2  sing N N 259 
LEU CG  HG   sing N N 260 
LEU CD1 HD11 sing N N 261 
LEU CD1 HD12 sing N N 262 
LEU CD1 HD13 sing N N 263 
LEU CD2 HD21 sing N N 264 
LEU CD2 HD22 sing N N 265 
LEU CD2 HD23 sing N N 266 
LEU OXT HXT  sing N N 267 
LYS N   CA   sing N N 268 
LYS N   H    sing N N 269 
LYS N   H2   sing N N 270 
LYS CA  C    sing N N 271 
LYS CA  CB   sing N N 272 
LYS CA  HA   sing N N 273 
LYS C   O    doub N N 274 
LYS C   OXT  sing N N 275 
LYS CB  CG   sing N N 276 
LYS CB  HB2  sing N N 277 
LYS CB  HB3  sing N N 278 
LYS CG  CD   sing N N 279 
LYS CG  HG2  sing N N 280 
LYS CG  HG3  sing N N 281 
LYS CD  CE   sing N N 282 
LYS CD  HD2  sing N N 283 
LYS CD  HD3  sing N N 284 
LYS CE  NZ   sing N N 285 
LYS CE  HE2  sing N N 286 
LYS CE  HE3  sing N N 287 
LYS NZ  HZ1  sing N N 288 
LYS NZ  HZ2  sing N N 289 
LYS NZ  HZ3  sing N N 290 
LYS OXT HXT  sing N N 291 
MET N   CA   sing N N 292 
MET N   H    sing N N 293 
MET N   H2   sing N N 294 
MET CA  C    sing N N 295 
MET CA  CB   sing N N 296 
MET CA  HA   sing N N 297 
MET C   O    doub N N 298 
MET C   OXT  sing N N 299 
MET CB  CG   sing N N 300 
MET CB  HB2  sing N N 301 
MET CB  HB3  sing N N 302 
MET CG  SD   sing N N 303 
MET CG  HG2  sing N N 304 
MET CG  HG3  sing N N 305 
MET SD  CE   sing N N 306 
MET CE  HE1  sing N N 307 
MET CE  HE2  sing N N 308 
MET CE  HE3  sing N N 309 
MET OXT HXT  sing N N 310 
PHE N   CA   sing N N 311 
PHE N   H    sing N N 312 
PHE N   H2   sing N N 313 
PHE CA  C    sing N N 314 
PHE CA  CB   sing N N 315 
PHE CA  HA   sing N N 316 
PHE C   O    doub N N 317 
PHE C   OXT  sing N N 318 
PHE CB  CG   sing N N 319 
PHE CB  HB2  sing N N 320 
PHE CB  HB3  sing N N 321 
PHE CG  CD1  doub Y N 322 
PHE CG  CD2  sing Y N 323 
PHE CD1 CE1  sing Y N 324 
PHE CD1 HD1  sing N N 325 
PHE CD2 CE2  doub Y N 326 
PHE CD2 HD2  sing N N 327 
PHE CE1 CZ   doub Y N 328 
PHE CE1 HE1  sing N N 329 
PHE CE2 CZ   sing Y N 330 
PHE CE2 HE2  sing N N 331 
PHE CZ  HZ   sing N N 332 
PHE OXT HXT  sing N N 333 
PRO N   CA   sing N N 334 
PRO N   CD   sing N N 335 
PRO N   H    sing N N 336 
PRO CA  C    sing N N 337 
PRO CA  CB   sing N N 338 
PRO CA  HA   sing N N 339 
PRO C   O    doub N N 340 
PRO C   OXT  sing N N 341 
PRO CB  CG   sing N N 342 
PRO CB  HB2  sing N N 343 
PRO CB  HB3  sing N N 344 
PRO CG  CD   sing N N 345 
PRO CG  HG2  sing N N 346 
PRO CG  HG3  sing N N 347 
PRO CD  HD2  sing N N 348 
PRO CD  HD3  sing N N 349 
PRO OXT HXT  sing N N 350 
SER N   CA   sing N N 351 
SER N   H    sing N N 352 
SER N   H2   sing N N 353 
SER CA  C    sing N N 354 
SER CA  CB   sing N N 355 
SER CA  HA   sing N N 356 
SER C   O    doub N N 357 
SER C   OXT  sing N N 358 
SER CB  OG   sing N N 359 
SER CB  HB2  sing N N 360 
SER CB  HB3  sing N N 361 
SER OG  HG   sing N N 362 
SER OXT HXT  sing N N 363 
THR N   CA   sing N N 364 
THR N   H    sing N N 365 
THR N   H2   sing N N 366 
THR CA  C    sing N N 367 
THR CA  CB   sing N N 368 
THR CA  HA   sing N N 369 
THR C   O    doub N N 370 
THR C   OXT  sing N N 371 
THR CB  OG1  sing N N 372 
THR CB  CG2  sing N N 373 
THR CB  HB   sing N N 374 
THR OG1 HG1  sing N N 375 
THR CG2 HG21 sing N N 376 
THR CG2 HG22 sing N N 377 
THR CG2 HG23 sing N N 378 
THR OXT HXT  sing N N 379 
TRP N   CA   sing N N 380 
TRP N   H    sing N N 381 
TRP N   H2   sing N N 382 
TRP CA  C    sing N N 383 
TRP CA  CB   sing N N 384 
TRP CA  HA   sing N N 385 
TRP C   O    doub N N 386 
TRP C   OXT  sing N N 387 
TRP CB  CG   sing N N 388 
TRP CB  HB2  sing N N 389 
TRP CB  HB3  sing N N 390 
TRP CG  CD1  doub Y N 391 
TRP CG  CD2  sing Y N 392 
TRP CD1 NE1  sing Y N 393 
TRP CD1 HD1  sing N N 394 
TRP CD2 CE2  doub Y N 395 
TRP CD2 CE3  sing Y N 396 
TRP NE1 CE2  sing Y N 397 
TRP NE1 HE1  sing N N 398 
TRP CE2 CZ2  sing Y N 399 
TRP CE3 CZ3  doub Y N 400 
TRP CE3 HE3  sing N N 401 
TRP CZ2 CH2  doub Y N 402 
TRP CZ2 HZ2  sing N N 403 
TRP CZ3 CH2  sing Y N 404 
TRP CZ3 HZ3  sing N N 405 
TRP CH2 HH2  sing N N 406 
TRP OXT HXT  sing N N 407 
TYR N   CA   sing N N 408 
TYR N   H    sing N N 409 
TYR N   H2   sing N N 410 
TYR CA  C    sing N N 411 
TYR CA  CB   sing N N 412 
TYR CA  HA   sing N N 413 
TYR C   O    doub N N 414 
TYR C   OXT  sing N N 415 
TYR CB  CG   sing N N 416 
TYR CB  HB2  sing N N 417 
TYR CB  HB3  sing N N 418 
TYR CG  CD1  doub Y N 419 
TYR CG  CD2  sing Y N 420 
TYR CD1 CE1  sing Y N 421 
TYR CD1 HD1  sing N N 422 
TYR CD2 CE2  doub Y N 423 
TYR CD2 HD2  sing N N 424 
TYR CE1 CZ   doub Y N 425 
TYR CE1 HE1  sing N N 426 
TYR CE2 CZ   sing Y N 427 
TYR CE2 HE2  sing N N 428 
TYR CZ  OH   sing N N 429 
TYR OH  HH   sing N N 430 
TYR OXT HXT  sing N N 431 
VAL N   CA   sing N N 432 
VAL N   H    sing N N 433 
VAL N   H2   sing N N 434 
VAL CA  C    sing N N 435 
VAL CA  CB   sing N N 436 
VAL CA  HA   sing N N 437 
VAL C   O    doub N N 438 
VAL C   OXT  sing N N 439 
VAL CB  CG1  sing N N 440 
VAL CB  CG2  sing N N 441 
VAL CB  HB   sing N N 442 
VAL CG1 HG11 sing N N 443 
VAL CG1 HG12 sing N N 444 
VAL CG1 HG13 sing N N 445 
VAL CG2 HG21 sing N N 446 
VAL CG2 HG22 sing N N 447 
VAL CG2 HG23 sing N N 448 
VAL OXT HXT  sing N N 449 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2023-08-14 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           8KEX 
_em_admin.last_update        2024-12-25 
_em_admin.map_release_date   2024-11-06 
_em_admin.title              'CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P, local' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
loop_
_em_entity_assembly_naturalsource.cell 
_em_entity_assembly_naturalsource.cellular_location 
_em_entity_assembly_naturalsource.entity_assembly_id 
_em_entity_assembly_naturalsource.id 
_em_entity_assembly_naturalsource.ncbi_tax_id 
_em_entity_assembly_naturalsource.organism 
_em_entity_assembly_naturalsource.organelle 
_em_entity_assembly_naturalsource.organ 
_em_entity_assembly_naturalsource.strain 
_em_entity_assembly_naturalsource.tissue 
_em_entity_assembly_naturalsource.details 
? ? 1 2 9606 'Homo sapiens'      ? ? ? ? ? 
? ? 1 3 562  'Escherichia coli'  ? ? ? ? ? 
? ? 1 4 6100 'Aequorea victoria' ? ? ? ? ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          7108 
_em_entity_assembly_recombinant.organism             'Spodoptera frugiperda' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         60 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K2 SUMMIT (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ? ? 
MASKING                    ? 3  ? ? ? ? ? 
'CTF CORRECTION'           ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ? ? 
'MODEL FITTING'            ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'         ? 8  ? ? ? ? ? 
OTHER                      ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ? ? 
CLASSIFICATION             ? 12 1 ? ? ? ? 
RECONSTRUCTION             ? 13 1 ? ? ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    8KEX 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
P 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . PRO A 1 138 ? 88.196  141.479 130.736 1.00 101.59 ?  22  PRO E N   1 
ATOM   2    C CA  . PRO A 1 138 ? 87.936  141.792 129.328 1.00 106.63 ?  22  PRO E CA  1 
ATOM   3    C C   . PRO A 1 138 ? 86.837  142.837 129.183 1.00 102.55 ?  22  PRO E C   1 
ATOM   4    O O   . PRO A 1 138 ? 85.853  142.772 129.919 1.00 94.34  ?  22  PRO E O   1 
ATOM   5    C CB  . PRO A 1 138 ? 87.492  140.447 128.741 1.00 107.91 ?  22  PRO E CB  1 
ATOM   6    C CG  . PRO A 1 138 ? 87.905  139.388 129.751 1.00 101.36 ?  22  PRO E CG  1 
ATOM   7    C CD  . PRO A 1 138 ? 88.548  140.063 130.928 1.00 101.25 ?  22  PRO E CD  1 
ATOM   8    N N   . CYS A 1 139 ? 87.007  143.793 128.266 1.00 103.13 ?  23  CYS E N   1 
ATOM   9    C CA  . CYS A 1 139 ? 86.001  144.839 128.109 1.00 103.26 ?  23  CYS E CA  1 
ATOM   10   C C   . CYS A 1 139 ? 84.671  144.249 127.657 1.00 100.53 ?  23  CYS E C   1 
ATOM   11   O O   . CYS A 1 139 ? 83.701  144.208 128.423 1.00 97.59  ?  23  CYS E O   1 
ATOM   12   C CB  . CYS A 1 139 ? 86.493  145.884 127.105 1.00 100.45 ?  23  CYS E CB  1 
ATOM   13   S SG  . CYS A 1 139 ? 88.243  146.316 127.256 1.00 96.33  ?  23  CYS E SG  1 
ATOM   14   N N   . TYR A 1 140 ? 84.608  143.783 126.411 1.00 110.62 ?  24  TYR E N   1 
ATOM   15   C CA  . TYR A 1 140 ? 83.519  142.924 125.965 1.00 110.52 ?  24  TYR E CA  1 
ATOM   16   C C   . TYR A 1 140 ? 84.067  141.753 125.158 1.00 109.04 ?  24  TYR E C   1 
ATOM   17   O O   . TYR A 1 140 ? 83.650  140.607 125.346 1.00 108.75 ?  24  TYR E O   1 
ATOM   18   C CB  . TYR A 1 140 ? 82.507  143.729 125.146 1.00 109.27 ?  24  TYR E CB  1 
ATOM   19   C CG  . TYR A 1 140 ? 81.082  143.545 125.607 1.00 107.40 ?  24  TYR E CG  1 
ATOM   20   C CD1 . TYR A 1 140 ? 80.640  144.113 126.792 1.00 110.71 ?  24  TYR E CD1 1 
ATOM   21   C CD2 . TYR A 1 140 ? 80.185  142.780 124.872 1.00 107.84 ?  24  TYR E CD2 1 
ATOM   22   C CE1 . TYR A 1 140 ? 79.341  143.940 127.227 1.00 113.57 ?  24  TYR E CE1 1 
ATOM   23   C CE2 . TYR A 1 140 ? 78.881  142.604 125.297 1.00 109.60 ?  24  TYR E CE2 1 
ATOM   24   C CZ  . TYR A 1 140 ? 78.465  143.185 126.478 1.00 113.04 ?  24  TYR E CZ  1 
ATOM   25   O OH  . TYR A 1 140 ? 77.171  143.014 126.912 1.00 112.69 ?  24  TYR E OH  1 
ATOM   26   N N   . ASN A 1 141 ? 85.053  142.041 124.313 1.00 92.61  ?  25  ASN E N   1 
ATOM   27   C CA  . ASN A 1 141 ? 85.600  141.144 123.297 1.00 92.67  ?  25  ASN E CA  1 
ATOM   28   C C   . ASN A 1 141 ? 87.037  141.580 123.020 1.00 92.65  ?  25  ASN E C   1 
ATOM   29   O O   . ASN A 1 141 ? 87.634  142.313 123.816 1.00 93.69  ?  25  ASN E O   1 
ATOM   30   C CB  . ASN A 1 141 ? 84.748  141.163 122.014 1.00 93.45  ?  25  ASN E CB  1 
ATOM   31   C CG  . ASN A 1 141 ? 83.359  140.581 122.203 1.00 94.28  ?  25  ASN E CG  1 
ATOM   32   O OD1 . ASN A 1 141 ? 83.158  139.651 122.982 1.00 93.73  ?  25  ASN E OD1 1 
ATOM   33   N ND2 . ASN A 1 141 ? 82.390  141.132 121.482 1.00 93.85  ?  25  ASN E ND2 1 
ATOM   34   N N   . GLN A 1 142 ? 87.594  141.112 121.899 1.00 68.26  ?  26  GLN E N   1 
ATOM   35   C CA  . GLN A 1 142 ? 88.915  141.527 121.422 1.00 65.03  ?  26  GLN E CA  1 
ATOM   36   C C   . GLN A 1 142 ? 90.014  141.177 122.417 1.00 63.13  ?  26  GLN E C   1 
ATOM   37   O O   . GLN A 1 142 ? 91.066  141.820 122.454 1.00 54.74  ?  26  GLN E O   1 
ATOM   38   C CB  . GLN A 1 142 ? 88.946  143.024 121.097 1.00 62.01  ?  26  GLN E CB  1 
ATOM   39   N N   . THR A 1 143 ? 89.775  140.149 123.227 1.00 74.67  ?  27  THR E N   1 
ATOM   40   C CA  . THR A 1 143 ? 90.742  139.687 124.209 1.00 76.96  ?  27  THR E CA  1 
ATOM   41   C C   . THR A 1 143 ? 91.370  138.352 123.853 1.00 77.66  ?  27  THR E C   1 
ATOM   42   O O   . THR A 1 143 ? 92.550  138.147 124.140 1.00 78.99  ?  27  THR E O   1 
ATOM   43   C CB  . THR A 1 143 ? 90.083  139.566 125.589 1.00 73.09  ?  27  THR E CB  1 
ATOM   44   O OG1 . THR A 1 143 ? 89.198  140.674 125.796 1.00 69.22  ?  27  THR E OG1 1 
ATOM   45   C CG2 . THR A 1 143 ? 91.137  139.555 126.685 1.00 70.37  ?  27  THR E CG2 1 
ATOM   46   N N   . LEU A 1 144 ? 90.611  137.447 123.229 1.00 72.51  ?  28  LEU E N   1 
ATOM   47   C CA  . LEU A 1 144 ? 91.113  136.107 122.948 1.00 66.74  ?  28  LEU E CA  1 
ATOM   48   C C   . LEU A 1 144 ? 92.296  136.145 121.987 1.00 70.91  ?  28  LEU E C   1 
ATOM   49   O O   . LEU A 1 144 ? 93.323  135.501 122.228 1.00 73.33  ?  28  LEU E O   1 
ATOM   50   C CB  . LEU A 1 144 ? 89.989  135.228 122.394 1.00 67.53  ?  28  LEU E CB  1 
ATOM   51   C CG  . LEU A 1 144 ? 89.177  135.705 121.185 1.00 69.94  ?  28  LEU E CG  1 
ATOM   52   C CD1 . LEU A 1 144 ? 88.658  134.511 120.403 1.00 73.58  ?  28  LEU E CD1 1 
ATOM   53   C CD2 . LEU A 1 144 ? 88.021  136.602 121.603 1.00 67.39  ?  28  LEU E CD2 1 
ATOM   54   N N   . SER A 1 145 ? 92.178  136.905 120.896 1.00 79.73  ?  29  SER E N   1 
ATOM   55   C CA  . SER A 1 145 ? 93.295  137.024 119.965 1.00 81.40  ?  29  SER E CA  1 
ATOM   56   C C   . SER A 1 145 ? 94.487  137.710 120.615 1.00 79.93  ?  29  SER E C   1 
ATOM   57   O O   . SER A 1 145 ? 95.639  137.349 120.342 1.00 77.39  ?  29  SER E O   1 
ATOM   58   C CB  . SER A 1 145 ? 92.860  137.784 118.712 1.00 80.95  ?  29  SER E CB  1 
ATOM   59   O OG  . SER A 1 145 ? 92.366  136.899 117.721 1.00 83.36  ?  29  SER E OG  1 
ATOM   60   N N   . PHE A 1 146 ? 94.229  138.691 121.481 1.00 73.03  ?  30  PHE E N   1 
ATOM   61   C CA  . PHE A 1 146 ? 95.312  139.419 122.131 1.00 70.35  ?  30  PHE E CA  1 
ATOM   62   C C   . PHE A 1 146 ? 96.103  138.502 123.057 1.00 70.19  ?  30  PHE E C   1 
ATOM   63   O O   . PHE A 1 146 ? 97.340  138.486 123.029 1.00 75.75  ?  30  PHE E O   1 
ATOM   64   C CB  . PHE A 1 146 ? 94.737  140.607 122.899 1.00 65.27  ?  30  PHE E CB  1 
ATOM   65   C CG  . PHE A 1 146 ? 95.567  141.849 122.805 1.00 70.78  ?  30  PHE E CG  1 
ATOM   66   C CD1 . PHE A 1 146 ? 96.808  141.924 123.406 1.00 70.66  ?  30  PHE E CD1 1 
ATOM   67   C CD2 . PHE A 1 146 ? 95.105  142.944 122.094 1.00 68.50  ?  30  PHE E CD2 1 
ATOM   68   C CE1 . PHE A 1 146 ? 97.565  143.075 123.306 1.00 69.53  ?  30  PHE E CE1 1 
ATOM   69   C CE2 . PHE A 1 146 ? 95.858  144.093 121.994 1.00 65.02  ?  30  PHE E CE2 1 
ATOM   70   C CZ  . PHE A 1 146 ? 97.090  144.158 122.601 1.00 66.22  ?  30  PHE E CZ  1 
ATOM   71   N N   . THR A 1 147 ? 95.403  137.701 123.867 1.00 65.16  ?  31  THR E N   1 
ATOM   72   C CA  . THR A 1 147 ? 96.114  136.777 124.742 1.00 62.66  ?  31  THR E CA  1 
ATOM   73   C C   . THR A 1 147 ? 96.732  135.630 123.957 1.00 69.09  ?  31  THR E C   1 
ATOM   74   O O   . THR A 1 147 ? 97.743  135.074 124.387 1.00 73.17  ?  31  THR E O   1 
ATOM   75   C CB  . THR A 1 147 ? 95.200  136.223 125.837 1.00 68.68  ?  31  THR E CB  1 
ATOM   76   O OG1 . THR A 1 147 ? 95.871  135.150 126.509 1.00 70.49  ?  31  THR E OG1 1 
ATOM   77   C CG2 . THR A 1 147 ? 93.925  135.672 125.252 1.00 68.72  ?  31  THR E CG2 1 
ATOM   78   N N   . VAL A 1 148 ? 96.159  135.267 122.806 1.00 69.33  ?  32  VAL E N   1 
ATOM   79   C CA  . VAL A 1 148 ? 96.779  134.246 121.965 1.00 65.71  ?  32  VAL E CA  1 
ATOM   80   C C   . VAL A 1 148 ? 98.116  134.740 121.426 1.00 61.68  ?  32  VAL E C   1 
ATOM   81   O O   . VAL A 1 148 ? 99.116  134.012 121.431 1.00 57.52  ?  32  VAL E O   1 
ATOM   82   C CB  . VAL A 1 148 ? 95.827  133.838 120.827 1.00 63.96  ?  32  VAL E CB  1 
ATOM   83   N N   . LEU A 1 149 ? 98.149  135.986 120.946 1.00 61.88  ?  33  LEU E N   1 
ATOM   84   C CA  . LEU A 1 149 ? 99.408  136.569 120.492 1.00 66.00  ?  33  LEU E CA  1 
ATOM   85   C C   . LEU A 1 149 ? 100.404 136.675 121.639 1.00 64.24  ?  33  LEU E C   1 
ATOM   86   O O   . LEU A 1 149 ? 101.595 136.378 121.471 1.00 66.96  ?  33  LEU E O   1 
ATOM   87   C CB  . LEU A 1 149 ? 99.158  137.942 119.869 1.00 64.51  ?  33  LEU E CB  1 
ATOM   88   N N   . THR A 1 150 ? 99.929  137.089 122.816 1.00 76.37  ?  34  THR E N   1 
ATOM   89   C CA  . THR A 1 150 ? 100.799 137.149 123.985 1.00 79.72  ?  34  THR E CA  1 
ATOM   90   C C   . THR A 1 150 ? 101.376 135.776 124.308 1.00 79.73  ?  34  THR E C   1 
ATOM   91   O O   . THR A 1 150 ? 102.568 135.650 124.603 1.00 77.12  ?  34  THR E O   1 
ATOM   92   C CB  . THR A 1 150 ? 100.027 137.701 125.184 1.00 76.83  ?  34  THR E CB  1 
ATOM   93   O OG1 . THR A 1 150 ? 99.600  139.039 124.905 1.00 78.90  ?  34  THR E OG1 1 
ATOM   94   C CG2 . THR A 1 150 ? 100.904 137.707 126.426 1.00 75.56  ?  34  THR E CG2 1 
ATOM   95   N N   . CYS A 1 151 ? 100.546 134.734 124.238 1.00 81.84  ?  35  CYS E N   1 
ATOM   96   C CA  . CYS A 1 151 ? 100.994 133.386 124.566 1.00 79.99  ?  35  CYS E CA  1 
ATOM   97   C C   . CYS A 1 151 ? 101.996 132.862 123.546 1.00 79.21  ?  35  CYS E C   1 
ATOM   98   O O   . CYS A 1 151 ? 102.962 132.191 123.914 1.00 81.51  ?  35  CYS E O   1 
ATOM   99   C CB  . CYS A 1 151 ? 99.793  132.448 124.670 1.00 83.38  ?  35  CYS E CB  1 
ATOM   100  S SG  . CYS A 1 151 ? 98.832  132.633 126.191 1.00 81.82  ?  35  CYS E SG  1 
ATOM   101  N N   . ILE A 1 152 ? 101.777 133.138 122.260 1.00 77.37  ?  36  ILE E N   1 
ATOM   102  C CA  . ILE A 1 152 ? 102.729 132.695 121.241 1.00 83.02  ?  36  ILE E CA  1 
ATOM   103  C C   . ILE A 1 152 ? 104.073 133.393 121.428 1.00 84.18  ?  36  ILE E C   1 
ATOM   104  O O   . ILE A 1 152 ? 105.144 132.764 121.359 1.00 81.27  ?  36  ILE E O   1 
ATOM   105  C CB  . ILE A 1 152 ? 102.157 132.934 119.832 1.00 83.35  ?  36  ILE E CB  1 
ATOM   106  N N   . ILE A 1 153 ? 104.036 134.708 121.666 1.00 82.22  ?  37  ILE E N   1 
ATOM   107  C CA  . ILE A 1 153 ? 105.266 135.454 121.908 1.00 76.79  ?  37  ILE E CA  1 
ATOM   108  C C   . ILE A 1 153 ? 105.963 134.927 123.154 1.00 74.04  ?  37  ILE E C   1 
ATOM   109  O O   . ILE A 1 153 ? 107.190 134.794 123.191 1.00 76.41  ?  37  ILE E O   1 
ATOM   110  C CB  . ILE A 1 153 ? 104.961 136.960 122.013 1.00 70.98  ?  37  ILE E CB  1 
ATOM   111  C CG1 . ILE A 1 153 ? 104.645 137.530 120.631 1.00 74.74  ?  37  ILE E CG1 1 
ATOM   112  C CG2 . ILE A 1 153 ? 106.131 137.703 122.629 1.00 74.11  ?  37  ILE E CG2 1 
ATOM   113  C CD1 . ILE A 1 153 ? 104.148 138.955 120.663 1.00 75.09  ?  37  ILE E CD1 1 
ATOM   114  N N   . SER A 1 154 ? 105.189 134.582 124.182 1.00 75.18  ?  38  SER E N   1 
ATOM   115  C CA  . SER A 1 154 ? 105.778 134.018 125.389 1.00 80.48  ?  38  SER E CA  1 
ATOM   116  C C   . SER A 1 154 ? 106.395 132.652 125.117 1.00 83.16  ?  38  SER E C   1 
ATOM   117  O O   . SER A 1 154 ? 107.445 132.319 125.673 1.00 84.00  ?  38  SER E O   1 
ATOM   118  C CB  . SER A 1 154 ? 104.723 133.924 126.489 1.00 80.79  ?  38  SER E CB  1 
ATOM   119  N N   . LEU A 1 155 ? 105.750 131.840 124.281 1.00 84.29  ?  39  LEU E N   1 
ATOM   120  C CA  . LEU A 1 155 ? 106.280 130.515 123.983 1.00 82.40  ?  39  LEU E CA  1 
ATOM   121  C C   . LEU A 1 155 ? 107.640 130.619 123.310 1.00 82.88  ?  39  LEU E C   1 
ATOM   122  O O   . LEU A 1 155 ? 108.609 129.970 123.730 1.00 83.55  ?  39  LEU E O   1 
ATOM   123  C CB  . LEU A 1 155 ? 105.296 129.744 123.105 1.00 79.90  ?  39  LEU E CB  1 
ATOM   124  C CG  . LEU A 1 155 ? 104.229 128.938 123.848 1.00 82.51  ?  39  LEU E CG  1 
ATOM   125  C CD1 . LEU A 1 155 ? 102.930 128.908 123.059 1.00 82.45  ?  39  LEU E CD1 1 
ATOM   126  C CD2 . LEU A 1 155 ? 104.725 127.528 124.125 1.00 83.99  ?  39  LEU E CD2 1 
ATOM   127  N N   . VAL A 1 156 ? 107.740 131.460 122.277 1.00 79.62  ?  40  VAL E N   1 
ATOM   128  C CA  . VAL A 1 156 ? 109.049 131.657 121.656 1.00 77.89  ?  40  VAL E CA  1 
ATOM   129  C C   . VAL A 1 156 ? 110.007 132.309 122.650 1.00 75.52  ?  40  VAL E C   1 
ATOM   130  O O   . VAL A 1 156 ? 111.224 132.091 122.598 1.00 71.39  ?  40  VAL E O   1 
ATOM   131  C CB  . VAL A 1 156 ? 108.927 132.454 120.340 1.00 75.63  ?  40  VAL E CB  1 
ATOM   132  C CG1 . VAL A 1 156 ? 108.071 133.683 120.510 1.00 75.96  ?  40  VAL E CG1 1 
ATOM   133  C CG2 . VAL A 1 156 ? 110.299 132.822 119.784 1.00 74.91  ?  40  VAL E CG2 1 
ATOM   134  N N   . GLY A 1 157 ? 109.471 133.077 123.604 1.00 79.92  ?  41  GLY E N   1 
ATOM   135  C CA  . GLY A 1 157 ? 110.317 133.674 124.624 1.00 80.30  ?  41  GLY E CA  1 
ATOM   136  C C   . GLY A 1 157 ? 110.999 132.652 125.512 1.00 81.55  ?  41  GLY E C   1 
ATOM   137  O O   . GLY A 1 157 ? 112.215 132.706 125.703 1.00 83.46  ?  41  GLY E O   1 
ATOM   138  N N   . LEU A 1 158 ? 110.231 131.716 126.080 1.00 77.73  ?  42  LEU E N   1 
ATOM   139  C CA  . LEU A 1 158 ? 110.867 130.660 126.868 1.00 77.32  ?  42  LEU E CA  1 
ATOM   140  C C   . LEU A 1 158 ? 111.740 129.767 126.003 1.00 82.05  ?  42  LEU E C   1 
ATOM   141  O O   . LEU A 1 158 ? 112.755 129.256 126.478 1.00 80.35  ?  42  LEU E O   1 
ATOM   142  C CB  . LEU A 1 158 ? 109.881 129.789 127.656 1.00 76.36  ?  42  LEU E CB  1 
ATOM   143  C CG  . LEU A 1 158 ? 108.858 130.193 128.721 1.00 80.48  ?  42  LEU E CG  1 
ATOM   144  C CD1 . LEU A 1 158 ? 107.753 131.031 128.216 1.00 78.01  ?  42  LEU E CD1 1 
ATOM   145  C CD2 . LEU A 1 158 ? 108.301 128.945 129.395 1.00 81.53  ?  42  LEU E CD2 1 
ATOM   146  N N   . THR A 1 159 ? 111.374 129.558 124.736 1.00 85.28  ?  43  THR E N   1 
ATOM   147  C CA  . THR A 1 159 ? 112.251 128.781 123.864 1.00 83.62  ?  43  THR E CA  1 
ATOM   148  C C   . THR A 1 159 ? 113.630 129.429 123.760 1.00 85.62  ?  43  THR E C   1 
ATOM   149  O O   . THR A 1 159 ? 114.660 128.786 124.018 1.00 83.36  ?  43  THR E O   1 
ATOM   150  C CB  . THR A 1 159 ? 111.619 128.631 122.480 1.00 84.29  ?  43  THR E CB  1 
ATOM   151  O OG1 . THR A 1 159 ? 110.283 128.131 122.615 1.00 84.58  ?  43  THR E OG1 1 
ATOM   152  C CG2 . THR A 1 159 ? 112.433 127.675 121.623 1.00 85.05  ?  43  THR E CG2 1 
ATOM   153  N N   . GLY A 1 160 ? 113.661 130.719 123.416 1.00 80.15  ?  44  GLY E N   1 
ATOM   154  C CA  . GLY A 1 160 ? 114.930 131.417 123.292 1.00 75.98  ?  44  GLY E CA  1 
ATOM   155  C C   . GLY A 1 160 ? 115.671 131.526 124.610 1.00 73.82  ?  44  GLY E C   1 
ATOM   156  O O   . GLY A 1 160 ? 116.892 131.349 124.665 1.00 76.03  ?  44  GLY E O   1 
ATOM   157  N N   . ASN A 1 161 ? 114.946 131.817 125.691 1.00 67.51  ?  45  ASN E N   1 
ATOM   158  C CA  . ASN A 1 161 ? 115.584 131.929 126.996 1.00 66.59  ?  45  ASN E CA  1 
ATOM   159  C C   . ASN A 1 161 ? 116.171 130.595 127.432 1.00 74.16  ?  45  ASN E C   1 
ATOM   160  O O   . ASN A 1 161 ? 117.265 130.550 128.000 1.00 75.53  ?  45  ASN E O   1 
ATOM   161  C CB  . ASN A 1 161 ? 114.585 132.446 128.029 1.00 77.45  ?  45  ASN E CB  1 
ATOM   162  C CG  . ASN A 1 161 ? 114.311 133.931 127.881 1.00 80.12  ?  45  ASN E CG  1 
ATOM   163  O OD1 . ASN A 1 161 ? 115.130 134.765 128.266 1.00 75.10  ?  45  ASN E OD1 1 
ATOM   164  N ND2 . ASN A 1 161 ? 113.152 134.267 127.327 1.00 81.09  ?  45  ASN E ND2 1 
ATOM   165  N N   . ALA A 1 162 ? 115.471 129.495 127.155 1.00 80.04  ?  46  ALA E N   1 
ATOM   166  C CA  . ALA A 1 162 ? 115.971 128.179 127.526 1.00 79.04  ?  46  ALA E CA  1 
ATOM   167  C C   . ALA A 1 162 ? 117.227 127.829 126.743 1.00 80.15  ?  46  ALA E C   1 
ATOM   168  O O   . ALA A 1 162 ? 118.205 127.336 127.315 1.00 79.93  ?  46  ALA E O   1 
ATOM   169  C CB  . ALA A 1 162 ? 114.885 127.126 127.307 1.00 79.59  ?  46  ALA E CB  1 
ATOM   170  N N   . VAL A 1 163 ? 117.227 128.076 125.428 1.00 78.41  ?  47  VAL E N   1 
ATOM   171  C CA  . VAL A 1 163 ? 118.417 127.716 124.661 1.00 76.43  ?  47  VAL E CA  1 
ATOM   172  C C   . VAL A 1 163 ? 119.603 128.582 125.078 1.00 74.30  ?  47  VAL E C   1 
ATOM   173  O O   . VAL A 1 163 ? 120.723 128.080 125.241 1.00 74.75  ?  47  VAL E O   1 
ATOM   174  C CB  . VAL A 1 163 ? 118.163 127.784 123.142 1.00 76.00  ?  47  VAL E CB  1 
ATOM   175  C CG1 . VAL A 1 163 ? 117.462 129.054 122.749 1.00 75.71  ?  47  VAL E CG1 1 
ATOM   176  C CG2 . VAL A 1 163 ? 119.471 127.637 122.374 1.00 76.86  ?  47  VAL E CG2 1 
ATOM   177  N N   . VAL A 1 164 ? 119.381 129.884 125.288 1.00 78.03  ?  48  VAL E N   1 
ATOM   178  C CA  . VAL A 1 164 ? 120.495 130.747 125.675 1.00 78.19  ?  48  VAL E CA  1 
ATOM   179  C C   . VAL A 1 164 ? 120.985 130.399 127.078 1.00 75.39  ?  48  VAL E C   1 
ATOM   180  O O   . VAL A 1 164 ? 122.190 130.444 127.352 1.00 74.47  ?  48  VAL E O   1 
ATOM   181  C CB  . VAL A 1 164 ? 120.115 132.236 125.545 1.00 73.37  ?  48  VAL E CB  1 
ATOM   182  C CG1 . VAL A 1 164 ? 119.070 132.636 126.562 1.00 71.99  ?  48  VAL E CG1 1 
ATOM   183  C CG2 . VAL A 1 164 ? 121.347 133.105 125.699 1.00 72.86  ?  48  VAL E CG2 1 
ATOM   184  N N   . LEU A 1 165 ? 120.072 130.033 127.982 1.00 72.14  ?  49  LEU E N   1 
ATOM   185  C CA  . LEU A 1 165 ? 120.476 129.623 129.322 1.00 69.79  ?  49  LEU E CA  1 
ATOM   186  C C   . LEU A 1 165 ? 121.292 128.339 129.276 1.00 72.21  ?  49  LEU E C   1 
ATOM   187  O O   . LEU A 1 165 ? 122.313 128.219 129.962 1.00 72.08  ?  49  LEU E O   1 
ATOM   188  C CB  . LEU A 1 165 ? 119.237 129.444 130.200 1.00 67.64  ?  49  LEU E CB  1 
ATOM   189  C CG  . LEU A 1 165 ? 119.347 129.804 131.682 1.00 71.22  ?  49  LEU E CG  1 
ATOM   190  C CD1 . LEU A 1 165 ? 120.115 131.098 131.864 1.00 70.27  ?  49  LEU E CD1 1 
ATOM   191  C CD2 . LEU A 1 165 ? 117.965 129.912 132.304 1.00 69.11  ?  49  LEU E CD2 1 
ATOM   192  N N   . TRP A 1 166 ? 120.861 127.373 128.462 1.00 81.65  ?  50  TRP E N   1 
ATOM   193  C CA  . TRP A 1 166 ? 121.598 126.121 128.336 1.00 81.48  ?  50  TRP E CA  1 
ATOM   194  C C   . TRP A 1 166 ? 122.987 126.358 127.760 1.00 83.56  ?  50  TRP E C   1 
ATOM   195  O O   . TRP A 1 166 ? 123.969 125.772 128.230 1.00 87.50  ?  50  TRP E O   1 
ATOM   196  C CB  . TRP A 1 166 ? 120.811 125.142 127.464 1.00 78.33  ?  50  TRP E CB  1 
ATOM   197  C CG  . TRP A 1 166 ? 121.634 124.027 126.901 1.00 79.62  ?  50  TRP E CG  1 
ATOM   198  C CD1 . TRP A 1 166 ? 122.410 123.148 127.597 1.00 81.17  ?  50  TRP E CD1 1 
ATOM   199  C CD2 . TRP A 1 166 ? 121.769 123.673 125.519 1.00 83.70  ?  50  TRP E CD2 1 
ATOM   200  N NE1 . TRP A 1 166 ? 123.016 122.267 126.736 1.00 84.17  ?  50  TRP E NE1 1 
ATOM   201  C CE2 . TRP A 1 166 ? 122.640 122.569 125.454 1.00 84.04  ?  50  TRP E CE2 1 
ATOM   202  C CE3 . TRP A 1 166 ? 121.237 124.182 124.330 1.00 83.69  ?  50  TRP E CE3 1 
ATOM   203  C CZ2 . TRP A 1 166 ? 122.992 121.965 124.249 1.00 79.87  ?  50  TRP E CZ2 1 
ATOM   204  C CZ3 . TRP A 1 166 ? 121.587 123.581 123.135 1.00 79.68  ?  50  TRP E CZ3 1 
ATOM   205  C CH2 . TRP A 1 166 ? 122.456 122.485 123.103 1.00 78.21  ?  50  TRP E CH2 1 
ATOM   206  N N   . LEU A 1 167 ? 123.093 127.215 126.742 1.00 77.99  ?  51  LEU E N   1 
ATOM   207  C CA  . LEU A 1 167 ? 124.397 127.472 126.138 1.00 75.90  ?  51  LEU E CA  1 
ATOM   208  C C   . LEU A 1 167 ? 125.317 128.233 127.086 1.00 78.80  ?  51  LEU E C   1 
ATOM   209  O O   . LEU A 1 167 ? 126.479 127.856 127.263 1.00 79.99  ?  51  LEU E O   1 
ATOM   210  C CB  . LEU A 1 167 ? 124.234 128.236 124.826 1.00 74.86  ?  51  LEU E CB  1 
ATOM   211  C CG  . LEU A 1 167 ? 123.449 127.537 123.717 1.00 79.08  ?  51  LEU E CG  1 
ATOM   212  C CD1 . LEU A 1 167 ? 123.241 128.473 122.540 1.00 78.76  ?  51  LEU E CD1 1 
ATOM   213  C CD2 . LEU A 1 167 ? 124.166 126.270 123.278 1.00 80.96  ?  51  LEU E CD2 1 
ATOM   214  N N   . LEU A 1 168 ? 124.819 129.302 127.709 1.00 77.46  ?  52  LEU E N   1 
ATOM   215  C CA  . LEU A 1 168 ? 125.689 130.156 128.508 1.00 71.49  ?  52  LEU E CA  1 
ATOM   216  C C   . LEU A 1 168 ? 126.023 129.516 129.850 1.00 69.51  ?  52  LEU E C   1 
ATOM   217  O O   . LEU A 1 168 ? 127.089 129.788 130.414 1.00 72.50  ?  52  LEU E O   1 
ATOM   218  C CB  . LEU A 1 168 ? 125.024 131.522 128.694 1.00 71.72  ?  52  LEU E CB  1 
ATOM   219  C CG  . LEU A 1 168 ? 125.860 132.801 128.821 1.00 68.99  ?  52  LEU E CG  1 
ATOM   220  C CD1 . LEU A 1 168 ? 124.940 134.006 128.795 1.00 72.73  ?  52  LEU E CD1 1 
ATOM   221  C CD2 . LEU A 1 168 ? 126.708 132.831 130.077 1.00 68.92  ?  52  LEU E CD2 1 
ATOM   222  N N   . GLY A 1 169 ? 125.143 128.658 130.367 1.00 77.86  ?  53  GLY E N   1 
ATOM   223  C CA  . GLY A 1 169 ? 125.384 128.066 131.672 1.00 85.01  ?  53  GLY E CA  1 
ATOM   224  C C   . GLY A 1 169 ? 126.623 127.194 131.714 1.00 85.07  ?  53  GLY E C   1 
ATOM   225  O O   . GLY A 1 169 ? 127.396 127.244 132.675 1.00 83.39  ?  53  GLY E O   1 
ATOM   226  N N   . TYR A 1 170 ? 126.834 126.388 130.676 1.00 81.19  ?  54  TYR E N   1 
ATOM   227  C CA  . TYR A 1 170 ? 127.934 125.432 130.652 1.00 82.50  ?  54  TYR E CA  1 
ATOM   228  C C   . TYR A 1 170 ? 128.863 125.630 129.465 1.00 82.27  ?  54  TYR E C   1 
ATOM   229  O O   . TYR A 1 170 ? 130.084 125.509 129.615 1.00 84.23  ?  54  TYR E O   1 
ATOM   230  C CB  . TYR A 1 170 ? 127.372 124.003 130.654 1.00 85.24  ?  54  TYR E CB  1 
ATOM   231  C CG  . TYR A 1 170 ? 126.010 123.899 131.301 1.00 84.61  ?  54  TYR E CG  1 
ATOM   232  C CD1 . TYR A 1 170 ? 125.870 123.948 132.682 1.00 83.89  ?  54  TYR E CD1 1 
ATOM   233  C CD2 . TYR A 1 170 ? 124.862 123.766 130.531 1.00 81.70  ?  54  TYR E CD2 1 
ATOM   234  C CE1 . TYR A 1 170 ? 124.627 123.859 133.278 1.00 82.77  ?  54  TYR E CE1 1 
ATOM   235  C CE2 . TYR A 1 170 ? 123.616 123.676 131.117 1.00 82.25  ?  54  TYR E CE2 1 
ATOM   236  C CZ  . TYR A 1 170 ? 123.504 123.723 132.490 1.00 83.40  ?  54  TYR E CZ  1 
ATOM   237  O OH  . TYR A 1 170 ? 122.262 123.633 133.077 1.00 82.41  ?  54  TYR E OH  1 
ATOM   238  N N   . ARG A 1 171 ? 128.323 125.932 128.289 1.00 85.55  ?  55  ARG E N   1 
ATOM   239  C CA  . ARG A 1 171 ? 129.138 126.131 127.090 1.00 90.14  ?  55  ARG E CA  1 
ATOM   240  C C   . ARG A 1 171 ? 129.569 127.589 126.945 1.00 89.15  ?  55  ARG E C   1 
ATOM   241  O O   . ARG A 1 171 ? 129.377 128.214 125.902 1.00 88.07  ?  55  ARG E O   1 
ATOM   242  C CB  . ARG A 1 171 ? 128.371 125.663 125.859 1.00 87.87  ?  55  ARG E CB  1 
ATOM   243  C CG  . ARG A 1 171 ? 128.306 124.153 125.685 1.00 82.71  ?  55  ARG E CG  1 
ATOM   244  C CD  . ARG A 1 171 ? 127.111 123.562 126.417 1.00 81.55  ?  55  ARG E CD  1 
ATOM   245  N NE  . ARG A 1 171 ? 127.087 122.107 126.339 1.00 86.34  ?  55  ARG E NE  1 
ATOM   246  C CZ  . ARG A 1 171 ? 126.374 121.326 127.139 1.00 87.15  ?  55  ARG E CZ  1 
ATOM   247  N NH1 . ARG A 1 171 ? 125.619 121.827 128.101 1.00 83.27  1  55  ARG E NH1 1 
ATOM   248  N NH2 . ARG A 1 171 ? 126.422 120.008 126.970 1.00 86.86  ?  55  ARG E NH2 1 
ATOM   249  N N   . MET A 1 172 ? 130.160 128.142 128.000 1.00 73.40  ?  56  MET E N   1 
ATOM   250  C CA  . MET A 1 172 ? 130.595 129.533 128.003 1.00 71.85  ?  56  MET E CA  1 
ATOM   251  C C   . MET A 1 172 ? 131.677 129.697 129.063 1.00 75.96  ?  56  MET E C   1 
ATOM   252  O O   . MET A 1 172 ? 131.976 128.771 129.822 1.00 72.02  ?  56  MET E O   1 
ATOM   253  C CB  . MET A 1 172 ? 129.420 130.482 128.247 1.00 73.90  ?  56  MET E CB  1 
ATOM   254  N N   . ARG A 1 173 ? 132.262 130.896 129.111 1.00 75.83  ?  57  ARG E N   1 
ATOM   255  C CA  . ARG A 1 173 ? 133.365 131.186 130.015 1.00 75.46  ?  57  ARG E CA  1 
ATOM   256  C C   . ARG A 1 173 ? 133.051 132.225 131.081 1.00 73.99  ?  57  ARG E C   1 
ATOM   257  O O   . ARG A 1 173 ? 133.852 132.379 132.010 1.00 72.54  ?  57  ARG E O   1 
ATOM   258  C CB  . ARG A 1 173 ? 134.597 131.659 129.224 1.00 68.93  ?  57  ARG E CB  1 
ATOM   259  N N   . ARG A 1 174 ? 131.925 132.937 130.980 1.00 68.43  ?  58  ARG E N   1 
ATOM   260  C CA  . ARG A 1 174 ? 131.529 133.967 131.944 1.00 70.23  ?  58  ARG E CA  1 
ATOM   261  C C   . ARG A 1 174 ? 132.615 135.042 132.061 1.00 68.77  ?  58  ARG E C   1 
ATOM   262  O O   . ARG A 1 174 ? 133.233 135.235 133.109 1.00 67.43  ?  58  ARG E O   1 
ATOM   263  C CB  . ARG A 1 174 ? 131.227 133.362 133.321 1.00 69.25  ?  58  ARG E CB  1 
ATOM   264  C CG  . ARG A 1 174 ? 130.525 132.013 133.321 1.00 69.65  ?  58  ARG E CG  1 
ATOM   265  C CD  . ARG A 1 174 ? 129.257 132.006 132.482 1.00 68.02  ?  58  ARG E CD  1 
ATOM   266  N NE  . ARG A 1 174 ? 128.458 130.809 132.719 1.00 68.97  ?  58  ARG E NE  1 
ATOM   267  C CZ  . ARG A 1 174 ? 127.902 130.486 133.881 1.00 68.85  ?  58  ARG E CZ  1 
ATOM   268  N NH1 . ARG A 1 174 ? 127.974 131.287 134.932 1.00 67.57  1  58  ARG E NH1 1 
ATOM   269  N NH2 . ARG A 1 174 ? 127.247 129.334 133.988 1.00 68.07  ?  58  ARG E NH2 1 
ATOM   270  N N   . ASN A 1 175 ? 132.837 135.741 130.947 1.00 63.15  ?  59  ASN E N   1 
ATOM   271  C CA  . ASN A 1 175 ? 134.011 136.602 130.870 1.00 64.31  ?  59  ASN E CA  1 
ATOM   272  C C   . ASN A 1 175 ? 133.870 137.866 131.710 1.00 63.49  ?  59  ASN E C   1 
ATOM   273  O O   . ASN A 1 175 ? 134.542 138.005 132.737 1.00 67.53  ?  59  ASN E O   1 
ATOM   274  C CB  . ASN A 1 175 ? 134.278 136.979 129.411 1.00 62.08  ?  59  ASN E CB  1 
ATOM   275  C CG  . ASN A 1 175 ? 133.000 137.220 128.630 1.00 60.74  ?  59  ASN E CG  1 
ATOM   276  O OD1 . ASN A 1 175 ? 131.905 137.202 129.191 1.00 61.45  ?  59  ASN E OD1 1 
ATOM   277  N ND2 . ASN A 1 175 ? 133.133 137.444 127.329 1.00 64.51  ?  59  ASN E ND2 1 
ATOM   278  N N   . ALA A 1 176 ? 133.005 138.791 131.296 1.00 50.20  ?  60  ALA E N   1 
ATOM   279  C CA  . ALA A 1 176 ? 132.695 139.954 132.124 1.00 51.72  ?  60  ALA E CA  1 
ATOM   280  C C   . ALA A 1 176 ? 131.236 140.378 132.100 1.00 47.00  ?  60  ALA E C   1 
ATOM   281  O O   . ALA A 1 176 ? 130.782 140.994 133.070 1.00 40.57  ?  60  ALA E O   1 
ATOM   282  C CB  . ALA A 1 176 ? 133.562 141.150 131.711 1.00 51.59  ?  60  ALA E CB  1 
ATOM   283  N N   . VAL A 1 177 ? 130.482 140.073 131.048 1.00 51.93  ?  61  VAL E N   1 
ATOM   284  C CA  . VAL A 1 177 ? 129.137 140.605 130.870 1.00 47.33  ?  61  VAL E CA  1 
ATOM   285  C C   . VAL A 1 177 ? 128.195 139.437 130.624 1.00 50.75  ?  61  VAL E C   1 
ATOM   286  O O   . VAL A 1 177 ? 126.990 139.524 130.884 1.00 56.54  ?  61  VAL E O   1 
ATOM   287  C CB  . VAL A 1 177 ? 129.099 141.624 129.713 1.00 50.78  ?  61  VAL E CB  1 
ATOM   288  C CG1 . VAL A 1 177 ? 127.679 142.082 129.422 1.00 49.85  ?  61  VAL E CG1 1 
ATOM   289  C CG2 . VAL A 1 177 ? 129.986 142.816 130.026 1.00 52.18  ?  61  VAL E CG2 1 
ATOM   290  N N   . SER A 1 178 ? 128.749 138.319 130.149 1.00 50.21  ?  62  SER E N   1 
ATOM   291  C CA  . SER A 1 178 ? 127.939 137.137 129.889 1.00 49.08  ?  62  SER E CA  1 
ATOM   292  C C   . SER A 1 178 ? 127.230 136.640 131.140 1.00 50.80  ?  62  SER E C   1 
ATOM   293  O O   . SER A 1 178 ? 126.199 135.971 131.028 1.00 61.94  ?  62  SER E O   1 
ATOM   294  C CB  . SER A 1 178 ? 128.809 136.033 129.295 1.00 58.25  ?  62  SER E CB  1 
ATOM   295  O OG  . SER A 1 178 ? 130.033 135.928 129.997 1.00 64.21  ?  62  SER E OG  1 
ATOM   296  N N   . ILE A 1 179 ? 127.750 136.958 132.327 1.00 47.72  ?  63  ILE E N   1 
ATOM   297  C CA  . ILE A 1 179 ? 127.007 136.686 133.553 1.00 50.22  ?  63  ILE E CA  1 
ATOM   298  C C   . ILE A 1 179 ? 125.713 137.489 133.572 1.00 44.03  ?  63  ILE E C   1 
ATOM   299  O O   . ILE A 1 179 ? 124.648 136.974 133.943 1.00 48.47  ?  63  ILE E O   1 
ATOM   300  C CB  . ILE A 1 179 ? 127.881 136.987 134.785 1.00 42.65  ?  63  ILE E CB  1 
ATOM   301  C CG1 . ILE A 1 179 ? 128.984 135.937 134.927 1.00 50.66  ?  63  ILE E CG1 1 
ATOM   302  C CG2 . ILE A 1 179 ? 127.032 137.041 136.043 1.00 46.00  ?  63  ILE E CG2 1 
ATOM   303  C CD1 . ILE A 1 179 ? 130.352 136.520 135.196 1.00 49.37  ?  63  ILE E CD1 1 
ATOM   304  N N   . TYR A 1 180 ? 125.789 138.766 133.179 1.00 36.00  ?  64  TYR E N   1 
ATOM   305  C CA  . TYR A 1 180 ? 124.595 139.602 133.120 1.00 39.74  ?  64  TYR E CA  1 
ATOM   306  C C   . TYR A 1 180 ? 123.582 139.040 132.136 1.00 43.16  ?  64  TYR E C   1 
ATOM   307  O O   . TYR A 1 180 ? 122.386 138.977 132.437 1.00 49.88  ?  64  TYR E O   1 
ATOM   308  C CB  . TYR A 1 180 ? 124.956 141.031 132.724 1.00 39.16  ?  64  TYR E CB  1 
ATOM   309  C CG  . TYR A 1 180 ? 125.834 141.772 133.697 1.00 42.22  ?  64  TYR E CG  1 
ATOM   310  C CD1 . TYR A 1 180 ? 125.415 142.029 134.993 1.00 31.65  ?  64  TYR E CD1 1 
ATOM   311  C CD2 . TYR A 1 180 ? 127.083 142.228 133.311 1.00 50.41  ?  64  TYR E CD2 1 
ATOM   312  C CE1 . TYR A 1 180 ? 126.223 142.715 135.875 1.00 32.34  ?  64  TYR E CE1 1 
ATOM   313  C CE2 . TYR A 1 180 ? 127.894 142.908 134.181 1.00 47.60  ?  64  TYR E CE2 1 
ATOM   314  C CZ  . TYR A 1 180 ? 127.463 143.152 135.460 1.00 41.24  ?  64  TYR E CZ  1 
ATOM   315  O OH  . TYR A 1 180 ? 128.289 143.836 136.317 1.00 45.79  ?  64  TYR E OH  1 
ATOM   316  N N   . ILE A 1 181 ? 124.039 138.628 130.953 1.00 45.05  ?  65  ILE E N   1 
ATOM   317  C CA  . ILE A 1 181 ? 123.121 138.040 129.984 1.00 44.09  ?  65  ILE E CA  1 
ATOM   318  C C   . ILE A 1 181 ? 122.517 136.760 130.541 1.00 51.63  ?  65  ILE E C   1 
ATOM   319  O O   . ILE A 1 181 ? 121.325 136.493 130.362 1.00 55.88  ?  65  ILE E O   1 
ATOM   320  C CB  . ILE A 1 181 ? 123.830 137.798 128.639 1.00 46.03  ?  65  ILE E CB  1 
ATOM   321  C CG1 . ILE A 1 181 ? 124.149 139.128 127.956 1.00 54.89  ?  65  ILE E CG1 1 
ATOM   322  C CG2 . ILE A 1 181 ? 122.970 136.944 127.726 1.00 49.98  ?  65  ILE E CG2 1 
ATOM   323  C CD1 . ILE A 1 181 ? 125.606 139.502 128.002 1.00 53.25  ?  65  ILE E CD1 1 
ATOM   324  N N   . LEU A 1 182 ? 123.317 135.968 131.254 1.00 58.32  ?  66  LEU E N   1 
ATOM   325  C CA  . LEU A 1 182 ? 122.831 134.702 131.792 1.00 56.80  ?  66  LEU E CA  1 
ATOM   326  C C   . LEU A 1 182 ? 121.697 134.919 132.791 1.00 59.39  ?  66  LEU E C   1 
ATOM   327  O O   . LEU A 1 182 ? 120.608 134.346 132.652 1.00 60.21  ?  66  LEU E O   1 
ATOM   328  C CB  . LEU A 1 182 ? 123.988 133.944 132.445 1.00 56.54  ?  66  LEU E CB  1 
ATOM   329  C CG  . LEU A 1 182 ? 123.651 132.677 133.230 1.00 61.56  ?  66  LEU E CG  1 
ATOM   330  C CD1 . LEU A 1 182 ? 123.701 131.456 132.328 1.00 61.95  ?  66  LEU E CD1 1 
ATOM   331  C CD2 . LEU A 1 182 ? 124.597 132.519 134.408 1.00 62.07  ?  66  LEU E CD2 1 
ATOM   332  N N   . ASN A 1 183 ? 121.924 135.763 133.801 1.00 54.09  ?  67  ASN E N   1 
ATOM   333  C CA  . ASN A 1 183 ? 120.874 135.894 134.809 1.00 55.28  ?  67  ASN E CA  1 
ATOM   334  C C   . ASN A 1 183 ? 119.722 136.750 134.302 1.00 56.10  ?  67  ASN E C   1 
ATOM   335  O O   . ASN A 1 183 ? 118.582 136.565 134.743 1.00 58.50  ?  67  ASN E O   1 
ATOM   336  C CB  . ASN A 1 183 ? 121.411 136.454 136.129 1.00 51.22  ?  67  ASN E CB  1 
ATOM   337  C CG  . ASN A 1 183 ? 122.467 137.495 135.936 1.00 50.68  ?  67  ASN E CG  1 
ATOM   338  O OD1 . ASN A 1 183 ? 122.534 138.122 134.892 1.00 55.70  ?  67  ASN E OD1 1 
ATOM   339  N ND2 . ASN A 1 183 ? 123.311 137.682 136.940 1.00 47.57  ?  67  ASN E ND2 1 
ATOM   340  N N   . LEU A 1 184 ? 119.981 137.665 133.363 1.00 45.14  ?  68  LEU E N   1 
ATOM   341  C CA  . LEU A 1 184 ? 118.890 138.385 132.722 1.00 44.52  ?  68  LEU E CA  1 
ATOM   342  C C   . LEU A 1 184 ? 118.008 137.434 131.928 1.00 52.12  ?  68  LEU E C   1 
ATOM   343  O O   . LEU A 1 184 ? 116.781 137.561 131.947 1.00 60.27  ?  68  LEU E O   1 
ATOM   344  C CB  . LEU A 1 184 ? 119.452 139.480 131.820 1.00 44.72  ?  68  LEU E CB  1 
ATOM   345  C CG  . LEU A 1 184 ? 118.521 140.025 130.739 1.00 45.90  ?  68  LEU E CG  1 
ATOM   346  C CD1 . LEU A 1 184 ? 117.541 141.009 131.347 1.00 53.12  ?  68  LEU E CD1 1 
ATOM   347  C CD2 . LEU A 1 184 ? 119.319 140.669 129.622 1.00 49.54  ?  68  LEU E CD2 1 
ATOM   348  N N   . ALA A 1 185 ? 118.613 136.466 131.236 1.00 51.53  ?  69  ALA E N   1 
ATOM   349  C CA  . ALA A 1 185 ? 117.836 135.472 130.508 1.00 52.85  ?  69  ALA E CA  1 
ATOM   350  C C   . ALA A 1 185 ? 117.063 134.570 131.459 1.00 58.08  ?  69  ALA E C   1 
ATOM   351  O O   . ALA A 1 185 ? 115.938 134.165 131.156 1.00 60.94  ?  69  ALA E O   1 
ATOM   352  C CB  . ALA A 1 185 ? 118.755 134.646 129.610 1.00 59.94  ?  69  ALA E CB  1 
ATOM   353  N N   . ALA A 1 186 ? 117.651 134.236 132.610 1.00 58.68  ?  70  ALA E N   1 
ATOM   354  C CA  . ALA A 1 186 ? 116.917 133.454 133.604 1.00 61.28  ?  70  ALA E CA  1 
ATOM   355  C C   . ALA A 1 186 ? 115.698 134.218 134.115 1.00 54.27  ?  70  ALA E C   1 
ATOM   356  O O   . ALA A 1 186 ? 114.583 133.677 134.179 1.00 52.52  ?  70  ALA E O   1 
ATOM   357  C CB  . ALA A 1 186 ? 117.843 133.079 134.761 1.00 59.89  ?  70  ALA E CB  1 
ATOM   358  N N   . ALA A 1 187 ? 115.892 135.489 134.473 1.00 49.56  ?  71  ALA E N   1 
ATOM   359  C CA  . ALA A 1 187 ? 114.777 136.308 134.934 1.00 51.75  ?  71  ALA E CA  1 
ATOM   360  C C   . ALA A 1 187 ? 113.732 136.477 133.841 1.00 53.38  ?  71  ALA E C   1 
ATOM   361  O O   . ALA A 1 187 ? 112.527 136.499 134.116 1.00 64.15  ?  71  ALA E O   1 
ATOM   362  C CB  . ALA A 1 187 ? 115.286 137.668 135.405 1.00 52.44  ?  71  ALA E CB  1 
ATOM   363  N N   . ASP A 1 188 ? 114.173 136.591 132.589 1.00 59.35  ?  72  ASP E N   1 
ATOM   364  C CA  . ASP A 1 188 ? 113.232 136.716 131.485 1.00 62.42  ?  72  ASP E CA  1 
ATOM   365  C C   . ASP A 1 188 ? 112.457 135.421 131.281 1.00 68.16  ?  72  ASP E C   1 
ATOM   366  O O   . ASP A 1 188 ? 111.270 135.448 130.942 1.00 69.60  ?  72  ASP E O   1 
ATOM   367  C CB  . ASP A 1 188 ? 113.978 137.103 130.211 1.00 68.23  ?  72  ASP E CB  1 
ATOM   368  C CG  . ASP A 1 188 ? 114.150 138.600 130.070 1.00 68.75  ?  72  ASP E CG  1 
ATOM   369  O OD1 . ASP A 1 188 ? 113.133 139.313 129.984 1.00 64.95  ?  72  ASP E OD1 1 
ATOM   370  O OD2 . ASP A 1 188 ? 115.308 139.065 130.037 1.00 70.07  -1 72  ASP E OD2 1 
ATOM   371  N N   . PHE A 1 189 ? 113.113 134.275 131.467 1.00 68.76  ?  73  PHE E N   1 
ATOM   372  C CA  . PHE A 1 189 ? 112.400 133.006 131.411 1.00 68.10  ?  73  PHE E CA  1 
ATOM   373  C C   . PHE A 1 189 ? 111.320 132.958 132.477 1.00 70.23  ?  73  PHE E C   1 
ATOM   374  O O   . PHE A 1 189 ? 110.191 132.527 132.212 1.00 71.43  ?  73  PHE E O   1 
ATOM   375  C CB  . PHE A 1 189 ? 113.377 131.843 131.580 1.00 62.76  ?  73  PHE E CB  1 
ATOM   376  N N   . LEU A 1 190 ? 111.646 133.425 133.684 1.00 64.45  ?  74  LEU E N   1 
ATOM   377  C CA  . LEU A 1 190 ? 110.634 133.541 134.732 1.00 64.28  ?  74  LEU E CA  1 
ATOM   378  C C   . LEU A 1 190 ? 109.486 134.442 134.285 1.00 63.47  ?  74  LEU E C   1 
ATOM   379  O O   . LEU A 1 190 ? 108.309 134.122 134.492 1.00 70.39  ?  74  LEU E O   1 
ATOM   380  C CB  . LEU A 1 190 ? 111.270 134.074 136.015 1.00 62.24  ?  74  LEU E CB  1 
ATOM   381  C CG  . LEU A 1 190 ? 112.365 133.205 136.636 1.00 69.49  ?  74  LEU E CG  1 
ATOM   382  C CD1 . LEU A 1 190 ? 112.873 133.832 137.921 1.00 67.52  ?  74  LEU E CD1 1 
ATOM   383  C CD2 . LEU A 1 190 ? 111.863 131.790 136.887 1.00 68.97  ?  74  LEU E CD2 1 
ATOM   384  N N   . PHE A 1 191 ? 109.820 135.579 133.670 1.00 56.20  ?  75  PHE E N   1 
ATOM   385  C CA  . PHE A 1 191 ? 108.810 136.499 133.148 1.00 55.57  ?  75  PHE E CA  1 
ATOM   386  C C   . PHE A 1 191 ? 107.849 135.817 132.183 1.00 64.21  ?  75  PHE E C   1 
ATOM   387  O O   . PHE A 1 191 ? 106.630 135.829 132.393 1.00 69.23  ?  75  PHE E O   1 
ATOM   388  C CB  . PHE A 1 191 ? 109.486 137.680 132.458 1.00 63.32  ?  75  PHE E CB  1 
ATOM   389  C CG  . PHE A 1 191 ? 108.636 138.910 132.400 1.00 63.67  ?  75  PHE E CG  1 
ATOM   390  C CD1 . PHE A 1 191 ? 107.700 139.058 131.389 1.00 67.07  ?  75  PHE E CD1 1 
ATOM   391  C CD2 . PHE A 1 191 ? 108.756 139.907 133.341 1.00 62.66  ?  75  PHE E CD2 1 
ATOM   392  C CE1 . PHE A 1 191 ? 106.908 140.179 131.315 1.00 67.18  ?  75  PHE E CE1 1 
ATOM   393  C CE2 . PHE A 1 191 ? 107.961 141.030 133.269 1.00 61.62  ?  75  PHE E CE2 1 
ATOM   394  C CZ  . PHE A 1 191 ? 107.038 141.167 132.256 1.00 64.48  ?  75  PHE E CZ  1 
ATOM   395  N N   . LEU A 1 192 ? 108.371 135.258 131.091 1.00 66.28  ?  76  LEU E N   1 
ATOM   396  C CA  . LEU A 1 192 ? 107.472 134.681 130.096 1.00 68.03  ?  76  LEU E CA  1 
ATOM   397  C C   . LEU A 1 192 ? 106.735 133.463 130.642 1.00 71.91  ?  76  LEU E C   1 
ATOM   398  O O   . LEU A 1 192 ? 105.586 133.211 130.250 1.00 76.77  ?  76  LEU E O   1 
ATOM   399  C CB  . LEU A 1 192 ? 108.206 134.314 128.801 1.00 76.15  ?  76  LEU E CB  1 
ATOM   400  C CG  . LEU A 1 192 ? 108.897 135.278 127.821 1.00 77.87  ?  76  LEU E CG  1 
ATOM   401  C CD1 . LEU A 1 192 ? 107.894 136.222 127.172 1.00 75.47  ?  76  LEU E CD1 1 
ATOM   402  C CD2 . LEU A 1 192 ? 110.053 136.044 128.389 1.00 75.14  ?  76  LEU E CD2 1 
ATOM   403  N N   . SER A 1 193 ? 107.359 132.701 131.546 1.00 67.57  ?  77  SER E N   1 
ATOM   404  C CA  . SER A 1 193 ? 106.648 131.604 132.194 1.00 73.40  ?  77  SER E CA  1 
ATOM   405  C C   . SER A 1 193 ? 105.450 132.127 132.970 1.00 72.21  ?  77  SER E C   1 
ATOM   406  O O   . SER A 1 193 ? 104.345 131.579 132.880 1.00 72.44  ?  77  SER E O   1 
ATOM   407  C CB  . SER A 1 193 ? 107.593 130.844 133.122 1.00 73.69  ?  77  SER E CB  1 
ATOM   408  O OG  . SER A 1 193 ? 108.083 131.696 134.142 1.00 73.49  ?  77  SER E OG  1 
ATOM   409  N N   . PHE A 1 194 ? 105.650 133.207 133.728 1.00 66.53  ?  78  PHE E N   1 
ATOM   410  C CA  . PHE A 1 194 ? 104.548 133.799 134.471 1.00 68.37  ?  78  PHE E CA  1 
ATOM   411  C C   . PHE A 1 194 ? 103.496 134.368 133.531 1.00 62.32  ?  78  PHE E C   1 
ATOM   412  O O   . PHE A 1 194 ? 102.312 134.391 133.870 1.00 65.43  ?  78  PHE E O   1 
ATOM   413  C CB  . PHE A 1 194 ? 105.073 134.888 135.402 1.00 69.84  ?  78  PHE E CB  1 
ATOM   414  C CG  . PHE A 1 194 ? 105.048 134.506 136.850 1.00 63.00  ?  78  PHE E CG  1 
ATOM   415  C CD1 . PHE A 1 194 ? 103.935 134.760 137.633 1.00 66.03  ?  78  PHE E CD1 1 
ATOM   416  C CD2 . PHE A 1 194 ? 106.146 133.904 137.431 1.00 58.95  ?  78  PHE E CD2 1 
ATOM   417  C CE1 . PHE A 1 194 ? 103.921 134.404 138.962 1.00 66.70  ?  78  PHE E CE1 1 
ATOM   418  C CE2 . PHE A 1 194 ? 106.139 133.551 138.759 1.00 66.57  ?  78  PHE E CE2 1 
ATOM   419  C CZ  . PHE A 1 194 ? 105.025 133.802 139.527 1.00 70.07  ?  78  PHE E CZ  1 
ATOM   420  N N   . GLN A 1 195 ? 103.910 134.831 132.352 1.00 68.80  ?  79  GLN E N   1 
ATOM   421  C CA  . GLN A 1 195 ? 102.951 135.322 131.365 1.00 75.23  ?  79  GLN E CA  1 
ATOM   422  C C   . GLN A 1 195 ? 102.046 134.194 130.869 1.00 77.46  ?  79  GLN E C   1 
ATOM   423  O O   . GLN A 1 195 ? 100.821 134.358 130.766 1.00 78.88  ?  79  GLN E O   1 
ATOM   424  C CB  . GLN A 1 195 ? 103.701 135.976 130.204 1.00 75.09  ?  79  GLN E CB  1 
ATOM   425  C CG  . GLN A 1 195 ? 104.236 137.374 130.515 1.00 72.15  ?  79  GLN E CG  1 
ATOM   426  C CD  . GLN A 1 195 ? 103.146 138.408 130.731 1.00 74.78  ?  79  GLN E CD  1 
ATOM   427  O OE1 . GLN A 1 195 ? 102.139 138.425 130.025 1.00 75.86  ?  79  GLN E OE1 1 
ATOM   428  N NE2 . GLN A 1 195 ? 103.314 139.233 131.753 1.00 71.09  ?  79  GLN E NE2 1 
ATOM   429  N N   . ILE A 1 196 ? 102.637 133.038 130.538 1.00 74.20  ?  80  ILE E N   1 
ATOM   430  C CA  . ILE A 1 196 ? 101.811 131.899 130.127 1.00 73.17  ?  80  ILE E CA  1 
ATOM   431  C C   . ILE A 1 196 ? 101.004 131.313 131.273 1.00 76.85  ?  80  ILE E C   1 
ATOM   432  O O   . ILE A 1 196 ? 99.978  130.668 131.026 1.00 84.17  ?  80  ILE E O   1 
ATOM   433  C CB  . ILE A 1 196 ? 102.596 130.741 129.482 1.00 79.30  ?  80  ILE E CB  1 
ATOM   434  C CG1 . ILE A 1 196 ? 103.749 131.257 128.633 1.00 81.36  ?  80  ILE E CG1 1 
ATOM   435  C CG2 . ILE A 1 196 ? 101.681 129.880 128.612 1.00 81.53  ?  80  ILE E CG2 1 
ATOM   436  C CD1 . ILE A 1 196 ? 104.472 130.148 127.911 1.00 78.52  ?  80  ILE E CD1 1 
ATOM   437  N N   . ILE A 1 197 ? 101.442 131.481 132.519 1.00 74.02  ?  81  ILE E N   1 
ATOM   438  C CA  . ILE A 1 197 ? 100.568 131.119 133.631 1.00 77.58  ?  81  ILE E CA  1 
ATOM   439  C C   . ILE A 1 197 ? 99.405  132.101 133.740 1.00 82.10  ?  81  ILE E C   1 
ATOM   440  O O   . ILE A 1 197 ? 98.261  131.702 133.984 1.00 83.83  ?  81  ILE E O   1 
ATOM   441  C CB  . ILE A 1 197 ? 101.360 131.022 134.948 1.00 77.53  ?  81  ILE E CB  1 
ATOM   442  C CG1 . ILE A 1 197 ? 102.540 130.062 134.794 1.00 78.86  ?  81  ILE E CG1 1 
ATOM   443  C CG2 . ILE A 1 197 ? 100.456 130.567 136.081 1.00 78.63  ?  81  ILE E CG2 1 
ATOM   444  C CD1 . ILE A 1 197 ? 103.329 129.847 136.068 1.00 78.04  ?  81  ILE E CD1 1 
ATOM   445  N N   . ARG A 1 198 ? 99.670  133.394 133.545 1.00 83.88  ?  82  ARG E N   1 
ATOM   446  C CA  . ARG A 1 198 ? 98.668  134.424 133.801 1.00 80.87  ?  82  ARG E CA  1 
ATOM   447  C C   . ARG A 1 198 ? 97.576  134.448 132.739 1.00 80.34  ?  82  ARG E C   1 
ATOM   448  O O   . ARG A 1 198 ? 96.395  134.246 133.043 1.00 83.77  ?  82  ARG E O   1 
ATOM   449  C CB  . ARG A 1 198 ? 99.335  135.799 133.892 1.00 82.25  ?  82  ARG E CB  1 
ATOM   450  C CG  . ARG A 1 198 ? 98.426  136.855 134.498 1.00 81.41  ?  82  ARG E CG  1 
ATOM   451  C CD  . ARG A 1 198 ? 98.508  138.179 133.753 1.00 74.52  ?  82  ARG E CD  1 
ATOM   452  N NE  . ARG A 1 198 ? 97.532  139.139 134.255 1.00 73.49  ?  82  ARG E NE  1 
ATOM   453  C CZ  . ARG A 1 198 ? 96.225  139.056 134.039 1.00 78.55  ?  82  ARG E CZ  1 
ATOM   454  N NH1 . ARG A 1 198 ? 95.705  138.090 133.299 1.00 81.95  1  82  ARG E NH1 1 
ATOM   455  N NH2 . ARG A 1 198 ? 95.420  139.968 134.575 1.00 77.68  ?  82  ARG E NH2 1 
ATOM   456  N N   . LEU A 1 199 ? 97.957  134.695 131.485 1.00 71.50  ?  83  LEU E N   1 
ATOM   457  C CA  . LEU A 1 199 ? 96.977  135.070 130.462 1.00 74.35  ?  83  LEU E CA  1 
ATOM   458  C C   . LEU A 1 199 ? 95.846  134.071 130.231 1.00 78.52  ?  83  LEU E C   1 
ATOM   459  O O   . LEU A 1 199 ? 94.690  134.514 130.110 1.00 78.56  ?  83  LEU E O   1 
ATOM   460  C CB  . LEU A 1 199 ? 97.691  135.397 129.147 1.00 78.72  ?  83  LEU E CB  1 
ATOM   461  C CG  . LEU A 1 199 ? 98.350  136.777 129.052 1.00 83.16  ?  83  LEU E CG  1 
ATOM   462  C CD1 . LEU A 1 199 ? 97.276  137.848 129.153 1.00 80.62  ?  83  LEU E CD1 1 
ATOM   463  C CD2 . LEU A 1 199 ? 99.386  137.010 130.117 1.00 81.33  ?  83  LEU E CD2 1 
ATOM   464  N N   . PRO A 1 200 ? 96.072  132.754 130.134 1.00 86.64  ?  84  PRO E N   1 
ATOM   465  C CA  . PRO A 1 200 ? 94.943  131.865 129.807 1.00 88.61  ?  84  PRO E CA  1 
ATOM   466  C C   . PRO A 1 200 ? 93.873  131.803 130.885 1.00 92.59  ?  84  PRO E C   1 
ATOM   467  O O   . PRO A 1 200 ? 92.768  131.322 130.602 1.00 89.16  ?  84  PRO E O   1 
ATOM   468  C CB  . PRO A 1 200 ? 95.602  130.494 129.588 1.00 88.22  ?  84  PRO E CB  1 
ATOM   469  C CG  . PRO A 1 200 ? 96.994  130.611 130.051 1.00 89.99  ?  84  PRO E CG  1 
ATOM   470  C CD  . PRO A 1 200 ? 97.270  131.994 130.524 1.00 85.25  ?  84  PRO E CD  1 
ATOM   471  N N   . LEU A 1 201 ? 94.151  132.277 132.099 1.00 93.26  ?  85  LEU E N   1 
ATOM   472  C CA  . LEU A 1 201 ? 93.144  132.357 133.150 1.00 86.16  ?  85  LEU E CA  1 
ATOM   473  C C   . LEU A 1 201 ? 92.297  133.621 133.075 1.00 84.38  ?  85  LEU E C   1 
ATOM   474  O O   . LEU A 1 201 ? 91.378  133.779 133.885 1.00 91.06  ?  85  LEU E O   1 
ATOM   475  C CB  . LEU A 1 201 ? 93.802  132.258 134.529 1.00 86.94  ?  85  LEU E CB  1 
ATOM   476  C CG  . LEU A 1 201 ? 94.128  130.835 134.992 1.00 90.43  ?  85  LEU E CG  1 
ATOM   477  C CD1 . LEU A 1 201 ? 95.464  130.362 134.450 1.00 87.99  ?  85  LEU E CD1 1 
ATOM   478  C CD2 . LEU A 1 201 ? 94.100  130.743 136.512 1.00 92.72  ?  85  LEU E CD2 1 
ATOM   479  N N   . ARG A 1 202 ? 92.580  134.522 132.132 1.00 73.70  ?  86  ARG E N   1 
ATOM   480  C CA  . ARG A 1 202 ? 91.747  135.710 131.978 1.00 78.76  ?  86  ARG E CA  1 
ATOM   481  C C   . ARG A 1 202 ? 90.416  135.385 131.311 1.00 80.38  ?  86  ARG E C   1 
ATOM   482  O O   . ARG A 1 202 ? 89.417  136.070 131.559 1.00 82.10  ?  86  ARG E O   1 
ATOM   483  C CB  . ARG A 1 202 ? 92.494  136.777 131.178 1.00 79.55  ?  86  ARG E CB  1 
ATOM   484  C CG  . ARG A 1 202 ? 91.756  138.103 131.073 1.00 80.27  ?  86  ARG E CG  1 
ATOM   485  C CD  . ARG A 1 202 ? 92.627  139.272 131.494 1.00 80.23  ?  86  ARG E CD  1 
ATOM   486  N NE  . ARG A 1 202 ? 91.991  140.550 131.195 1.00 84.26  ?  86  ARG E NE  1 
ATOM   487  C CZ  . ARG A 1 202 ? 92.529  141.734 131.455 1.00 81.65  ?  86  ARG E CZ  1 
ATOM   488  N NH1 . ARG A 1 202 ? 93.714  141.842 132.029 1.00 79.16  1  86  ARG E NH1 1 
ATOM   489  N NH2 . ARG A 1 202 ? 91.858  142.836 131.133 1.00 76.69  ?  86  ARG E NH2 1 
ATOM   490  N N   . LEU A 1 203 ? 90.376  134.351 130.474 1.00 83.77  ?  87  LEU E N   1 
ATOM   491  C CA  . LEU A 1 203 ? 89.167  134.027 129.727 1.00 83.39  ?  87  LEU E CA  1 
ATOM   492  C C   . LEU A 1 203 ? 88.241  133.082 130.484 1.00 80.68  ?  87  LEU E C   1 
ATOM   493  O O   . LEU A 1 203 ? 87.024  133.108 130.266 1.00 73.76  ?  87  LEU E O   1 
ATOM   494  C CB  . LEU A 1 203 ? 89.541  133.418 128.372 1.00 83.96  ?  87  LEU E CB  1 
ATOM   495  C CG  . LEU A 1 203 ? 88.470  133.386 127.278 1.00 85.52  ?  87  LEU E CG  1 
ATOM   496  C CD1 . LEU A 1 203 ? 88.096  134.793 126.843 1.00 84.02  ?  87  LEU E CD1 1 
ATOM   497  C CD2 . LEU A 1 203 ? 88.959  132.574 126.088 1.00 84.40  ?  87  LEU E CD2 1 
ATOM   498  N N   . ILE A 1 204 ? 88.786  132.249 131.368 1.00 89.16  ?  88  ILE E N   1 
ATOM   499  C CA  . ILE A 1 204 ? 88.019  131.229 132.075 1.00 90.21  ?  88  ILE E CA  1 
ATOM   500  C C   . ILE A 1 204 ? 88.274  131.373 133.571 1.00 90.65  ?  88  ILE E C   1 
ATOM   501  O O   . ILE A 1 204 ? 89.415  131.597 133.992 1.00 89.06  ?  88  ILE E O   1 
ATOM   502  C CB  . ILE A 1 204 ? 88.381  129.813 131.585 1.00 89.44  ?  88  ILE E CB  1 
ATOM   503  C CG1 . ILE A 1 204 ? 87.608  128.749 132.365 1.00 85.12  ?  88  ILE E CG1 1 
ATOM   504  C CG2 . ILE A 1 204 ? 89.881  129.572 131.685 1.00 88.91  ?  88  ILE E CG2 1 
ATOM   505  C CD1 . ILE A 1 204 ? 86.110  128.811 132.158 1.00 86.47  ?  88  ILE E CD1 1 
ATOM   506  N N   . ASN A 1 205 ? 87.206  131.259 134.366 1.00 104.64 ?  89  ASN E N   1 
ATOM   507  C CA  . ASN A 1 205 ? 87.274  131.280 135.830 1.00 106.61 ?  89  ASN E CA  1 
ATOM   508  C C   . ASN A 1 205 ? 87.901  132.583 136.339 1.00 104.14 ?  89  ASN E C   1 
ATOM   509  O O   . ASN A 1 205 ? 88.978  132.607 136.939 1.00 102.86 ?  89  ASN E O   1 
ATOM   510  C CB  . ASN A 1 205 ? 88.028  130.057 136.365 1.00 107.31 ?  89  ASN E CB  1 
ATOM   511  C CG  . ASN A 1 205 ? 87.179  128.801 136.365 1.00 106.55 ?  89  ASN E CG  1 
ATOM   512  O OD1 . ASN A 1 205 ? 86.544  128.465 135.368 1.00 106.78 ?  89  ASN E OD1 1 
ATOM   513  N ND2 . ASN A 1 205 ? 87.164  128.100 137.493 1.00 104.29 ?  89  ASN E ND2 1 
ATOM   514  N N   . ILE A 1 206 ? 87.185  133.676 136.072 1.00 91.45  ?  90  ILE E N   1 
ATOM   515  C CA  . ILE A 1 206 ? 87.601  134.979 136.575 1.00 90.93  ?  90  ILE E CA  1 
ATOM   516  C C   . ILE A 1 206 ? 87.517  134.981 138.095 1.00 92.53  ?  90  ILE E C   1 
ATOM   517  O O   . ILE A 1 206 ? 86.527  134.528 138.683 1.00 88.21  ?  90  ILE E O   1 
ATOM   518  C CB  . ILE A 1 206 ? 86.743  136.086 135.942 1.00 92.98  ?  90  ILE E CB  1 
ATOM   519  C CG1 . ILE A 1 206 ? 87.162  137.465 136.456 1.00 93.30  ?  90  ILE E CG1 1 
ATOM   520  C CG2 . ILE A 1 206 ? 85.256  135.823 136.162 1.00 94.74  ?  90  ILE E CG2 1 
ATOM   521  C CD1 . ILE A 1 206 ? 87.050  138.555 135.414 1.00 89.00  ?  90  ILE E CD1 1 
ATOM   522  N N   . SER A 1 207 ? 88.571  135.480 138.741 1.00 93.81  ?  91  SER E N   1 
ATOM   523  C CA  . SER A 1 207 ? 88.689  135.408 140.194 1.00 93.62  ?  91  SER E CA  1 
ATOM   524  C C   . SER A 1 207 ? 88.998  136.768 140.810 1.00 91.42  ?  91  SER E C   1 
ATOM   525  O O   . SER A 1 207 ? 88.597  137.043 141.946 1.00 90.00  ?  91  SER E O   1 
ATOM   526  C CB  . SER A 1 207 ? 89.766  134.397 140.574 1.00 89.09  ?  91  SER E CB  1 
ATOM   527  O OG  . SER A 1 207 ? 90.901  134.569 139.750 1.00 86.53  ?  91  SER E OG  1 
ATOM   528  N N   . HIS A 1 208 ? 89.748  137.597 140.082 1.00 88.95  ?  92  HIS E N   1 
ATOM   529  C CA  . HIS A 1 208 ? 89.967  139.003 140.411 1.00 91.72  ?  92  HIS E CA  1 
ATOM   530  C C   . HIS A 1 208 ? 90.867  139.208 141.627 1.00 96.51  ?  92  HIS E C   1 
ATOM   531  O O   . HIS A 1 208 ? 91.132  140.351 142.006 1.00 98.78  ?  92  HIS E O   1 
ATOM   532  C CB  . HIS A 1 208 ? 88.629  139.713 140.642 1.00 94.97  ?  92  HIS E CB  1 
ATOM   533  C CG  . HIS A 1 208 ? 88.015  140.270 139.397 1.00 96.05  ?  92  HIS E CG  1 
ATOM   534  N ND1 . HIS A 1 208 ? 86.661  140.210 139.147 1.00 94.76  ?  92  HIS E ND1 1 
ATOM   535  C CD2 . HIS A 1 208 ? 88.568  140.891 138.329 1.00 95.28  ?  92  HIS E CD2 1 
ATOM   536  C CE1 . HIS A 1 208 ? 86.405  140.774 137.981 1.00 92.90  ?  92  HIS E CE1 1 
ATOM   537  N NE2 . HIS A 1 208 ? 87.545  141.196 137.464 1.00 93.78  ?  92  HIS E NE2 1 
ATOM   538  N N   . LEU A 1 209 ? 91.335  138.129 142.258 1.00 86.94  ?  93  LEU E N   1 
ATOM   539  C CA  . LEU A 1 209 ? 92.227  138.282 143.406 1.00 80.86  ?  93  LEU E CA  1 
ATOM   540  C C   . LEU A 1 209 ? 93.581  137.639 143.134 1.00 80.87  ?  93  LEU E C   1 
ATOM   541  O O   . LEU A 1 209 ? 94.634  138.279 143.283 1.00 85.82  ?  93  LEU E O   1 
ATOM   542  C CB  . LEU A 1 209 ? 91.582  137.680 144.655 1.00 80.18  ?  93  LEU E CB  1 
ATOM   543  C CG  . LEU A 1 209 ? 90.292  138.320 145.182 1.00 85.58  ?  93  LEU E CG  1 
ATOM   544  C CD1 . LEU A 1 209 ? 90.073  137.966 146.644 1.00 82.85  ?  93  LEU E CD1 1 
ATOM   545  C CD2 . LEU A 1 209 ? 90.309  139.828 145.006 1.00 83.10  ?  93  LEU E CD2 1 
ATOM   546  N N   . ILE A 1 210 ? 93.572  136.371 142.719 1.00 82.22  ?  94  ILE E N   1 
ATOM   547  C CA  . ILE A 1 210 ? 94.821  135.702 142.373 1.00 85.04  ?  94  ILE E CA  1 
ATOM   548  C C   . ILE A 1 210 ? 95.505  136.436 141.229 1.00 83.03  ?  94  ILE E C   1 
ATOM   549  O O   . ILE A 1 210 ? 96.730  136.399 141.096 1.00 79.77  ?  94  ILE E O   1 
ATOM   550  C CB  . ILE A 1 210 ? 94.576  134.218 142.041 1.00 84.70  ?  94  ILE E CB  1 
ATOM   551  C CG1 . ILE A 1 210 ? 93.688  134.070 140.807 1.00 84.48  ?  94  ILE E CG1 1 
ATOM   552  C CG2 . ILE A 1 210 ? 93.957  133.501 143.230 1.00 80.54  ?  94  ILE E CG2 1 
ATOM   553  C CD1 . ILE A 1 210 ? 94.437  133.759 139.526 1.00 79.73  ?  94  ILE E CD1 1 
ATOM   554  N N   . ARG A 1 211 ? 94.720  137.129 140.398 1.00 75.80  ?  95  ARG E N   1 
ATOM   555  C CA  . ARG A 1 211 ? 95.276  137.953 139.330 1.00 74.93  ?  95  ARG E CA  1 
ATOM   556  C C   . ARG A 1 211 ? 96.165  139.050 139.897 1.00 76.63  ?  95  ARG E C   1 
ATOM   557  O O   . ARG A 1 211 ? 97.286  139.282 139.418 1.00 80.87  ?  95  ARG E O   1 
ATOM   558  C CB  . ARG A 1 211 ? 94.133  138.553 138.513 1.00 79.31  ?  95  ARG E CB  1 
ATOM   559  C CG  . ARG A 1 211 ? 93.246  137.515 137.866 1.00 78.68  ?  95  ARG E CG  1 
ATOM   560  C CD  . ARG A 1 211 ? 92.763  137.979 136.514 1.00 78.49  ?  95  ARG E CD  1 
ATOM   561  N NE  . ARG A 1 211 ? 91.584  137.236 136.091 1.00 74.85  ?  95  ARG E NE  1 
ATOM   562  C CZ  . ARG A 1 211 ? 90.835  137.559 135.048 1.00 77.14  ?  95  ARG E CZ  1 
ATOM   563  N NH1 . ARG A 1 211 ? 91.092  138.630 134.318 1.00 76.79  1  95  ARG E NH1 1 
ATOM   564  N NH2 . ARG A 1 211 ? 89.800  136.788 134.731 1.00 77.52  ?  95  ARG E NH2 1 
ATOM   565  N N   . LYS A 1 212 ? 95.664  139.737 140.927 1.00 67.55  ?  96  LYS E N   1 
ATOM   566  C CA  . LYS A 1 212 ? 96.478  140.712 141.639 1.00 66.24  ?  96  LYS E CA  1 
ATOM   567  C C   . LYS A 1 212 ? 97.711  140.056 142.236 1.00 72.28  ?  96  LYS E C   1 
ATOM   568  O O   . LYS A 1 212 ? 98.804  140.635 142.217 1.00 68.68  ?  96  LYS E O   1 
ATOM   569  C CB  . LYS A 1 212 ? 95.652  141.404 142.721 1.00 67.49  ?  96  LYS E CB  1 
ATOM   570  C CG  . LYS A 1 212 ? 94.173  141.492 142.420 1.00 69.97  ?  96  LYS E CG  1 
ATOM   571  C CD  . LYS A 1 212 ? 93.913  142.649 141.469 1.00 69.13  ?  96  LYS E CD  1 
ATOM   572  C CE  . LYS A 1 212 ? 92.438  142.994 141.391 1.00 68.33  ?  96  LYS E CE  1 
ATOM   573  N NZ  . LYS A 1 212 ? 91.888  143.362 142.726 1.00 67.51  1  96  LYS E NZ  1 
ATOM   574  N N   . ILE A 1 213 ? 97.562  138.839 142.766 1.00 76.90  ?  97  ILE E N   1 
ATOM   575  C CA  . ILE A 1 213 ? 98.755  138.171 143.283 1.00 72.78  ?  97  ILE E CA  1 
ATOM   576  C C   . ILE A 1 213 ? 99.784  137.932 142.180 1.00 67.61  ?  97  ILE E C   1 
ATOM   577  O O   . ILE A 1 213 ? 100.980 138.176 142.392 1.00 69.47  ?  97  ILE E O   1 
ATOM   578  C CB  . ILE A 1 213 ? 98.416  136.861 144.023 1.00 74.65  ?  97  ILE E CB  1 
ATOM   579  C CG1 . ILE A 1 213 ? 97.032  136.915 144.675 1.00 73.90  ?  97  ILE E CG1 1 
ATOM   580  C CG2 . ILE A 1 213 ? 99.489  136.545 145.059 1.00 76.80  ?  97  ILE E CG2 1 
ATOM   581  C CD1 . ILE A 1 213 ? 96.887  137.979 145.746 1.00 70.90  ?  97  ILE E CD1 1 
ATOM   582  N N   . LEU A 1 214 ? 99.367  137.457 140.999 1.00 65.98  ?  98  LEU E N   1 
ATOM   583  C CA  . LEU A 1 214 ? 100.370 137.176 139.972 1.00 72.00  ?  98  LEU E CA  1 
ATOM   584  C C   . LEU A 1 214 ? 101.041 138.452 139.485 1.00 73.39  ?  98  LEU E C   1 
ATOM   585  O O   . LEU A 1 214 ? 102.253 138.459 139.258 1.00 73.72  ?  98  LEU E O   1 
ATOM   586  C CB  . LEU A 1 214 ? 99.844  136.393 138.758 1.00 78.33  ?  98  LEU E CB  1 
ATOM   587  C CG  . LEU A 1 214 ? 98.942  135.163 138.565 1.00 79.56  ?  98  LEU E CG  1 
ATOM   588  C CD1 . LEU A 1 214 ? 97.471  135.457 138.474 1.00 76.87  ?  98  LEU E CD1 1 
ATOM   589  C CD2 . LEU A 1 214 ? 99.406  134.355 137.355 1.00 73.21  ?  98  LEU E CD2 1 
ATOM   590  N N   . VAL A 1 215 ? 100.284 139.538 139.294 1.00 68.73  ?  99  VAL E N   1 
ATOM   591  C CA  . VAL A 1 215 ? 100.948 140.756 138.824 1.00 62.00  ?  99  VAL E CA  1 
ATOM   592  C C   . VAL A 1 215 ? 101.882 141.297 139.904 1.00 65.58  ?  99  VAL E C   1 
ATOM   593  O O   . VAL A 1 215 ? 102.988 141.774 139.609 1.00 70.47  ?  99  VAL E O   1 
ATOM   594  C CB  . VAL A 1 215 ? 99.934  141.817 138.349 1.00 61.08  ?  99  VAL E CB  1 
ATOM   595  C CG1 . VAL A 1 215 ? 99.411  141.474 136.951 1.00 61.17  ?  99  VAL E CG1 1 
ATOM   596  C CG2 . VAL A 1 215 ? 98.803  141.991 139.329 1.00 72.02  ?  99  VAL E CG2 1 
ATOM   597  N N   . SER A 1 216 ? 101.477 141.189 141.173 1.00 66.53  ?  100 SER E N   1 
ATOM   598  C CA  . SER A 1 216 ? 102.355 141.598 142.262 1.00 69.42  ?  100 SER E CA  1 
ATOM   599  C C   . SER A 1 216 ? 103.669 140.828 142.249 1.00 73.08  ?  100 SER E C   1 
ATOM   600  O O   . SER A 1 216 ? 104.744 141.428 142.363 1.00 69.67  ?  100 SER E O   1 
ATOM   601  C CB  . SER A 1 216 ? 101.652 141.403 143.598 1.00 79.94  ?  100 SER E CB  1 
ATOM   602  O OG  . SER A 1 216 ? 102.471 141.867 144.653 1.00 81.91  ?  100 SER E OG  1 
ATOM   603  N N   . VAL A 1 217 ? 103.610 139.499 142.134 1.00 75.06  ?  101 VAL E N   1 
ATOM   604  C CA  . VAL A 1 217 ? 104.863 138.746 142.159 1.00 65.25  ?  101 VAL E CA  1 
ATOM   605  C C   . VAL A 1 217 ? 105.658 138.992 140.881 1.00 61.85  ?  101 VAL E C   1 
ATOM   606  O O   . VAL A 1 217 ? 106.889 139.078 140.919 1.00 70.86  ?  101 VAL E O   1 
ATOM   607  C CB  . VAL A 1 217 ? 104.629 137.241 142.399 1.00 67.35  ?  101 VAL E CB  1 
ATOM   608  C CG1 . VAL A 1 217 ? 103.539 136.701 141.512 1.00 65.43  ?  101 VAL E CG1 1 
ATOM   609  C CG2 . VAL A 1 217 ? 105.926 136.455 142.225 1.00 65.60  ?  101 VAL E CG2 1 
ATOM   610  N N   . MET A 1 218 ? 104.977 139.134 139.738 1.00 67.52  ?  102 MET E N   1 
ATOM   611  C CA  . MET A 1 218 ? 105.642 139.335 138.454 1.00 70.73  ?  102 MET E CA  1 
ATOM   612  C C   . MET A 1 218 ? 106.335 140.685 138.373 1.00 67.87  ?  102 MET E C   1 
ATOM   613  O O   . MET A 1 218 ? 107.233 140.868 137.543 1.00 60.55  ?  102 MET E O   1 
ATOM   614  C CB  . MET A 1 218 ? 104.623 139.204 137.320 1.00 65.07  ?  102 MET E CB  1 
ATOM   615  C CG  . MET A 1 218 ? 105.208 138.890 135.956 1.00 63.69  ?  102 MET E CG  1 
ATOM   616  S SD  . MET A 1 218 ? 103.937 138.908 134.678 1.00 82.73  ?  102 MET E SD  1 
ATOM   617  C CE  . MET A 1 218 ? 102.611 138.049 135.522 1.00 71.75  ?  102 MET E CE  1 
ATOM   618  N N   . THR A 1 219 ? 105.922 141.638 139.208 1.00 60.65  ?  103 THR E N   1 
ATOM   619  C CA  . THR A 1 219 ? 106.647 142.897 139.307 1.00 57.68  ?  103 THR E CA  1 
ATOM   620  C C   . THR A 1 219 ? 108.124 142.689 139.634 1.00 58.09  ?  103 THR E C   1 
ATOM   621  O O   . THR A 1 219 ? 108.966 143.447 139.141 1.00 64.78  ?  103 THR E O   1 
ATOM   622  C CB  . THR A 1 219 ? 105.967 143.789 140.353 1.00 66.27  ?  103 THR E CB  1 
ATOM   623  O OG1 . THR A 1 219 ? 104.847 144.453 139.754 1.00 70.33  ?  103 THR E OG1 1 
ATOM   624  C CG2 . THR A 1 219 ? 106.925 144.828 140.923 1.00 64.66  ?  103 THR E CG2 1 
ATOM   625  N N   . PHE A 1 220 ? 108.463 141.653 140.402 1.00 46.54  ?  104 PHE E N   1 
ATOM   626  C CA  . PHE A 1 220 ? 109.853 141.455 140.812 1.00 44.05  ?  104 PHE E CA  1 
ATOM   627  C C   . PHE A 1 220 ? 110.749 140.985 139.669 1.00 49.81  ?  104 PHE E C   1 
ATOM   628  O O   . PHE A 1 220 ? 111.822 141.585 139.473 1.00 56.83  ?  104 PHE E O   1 
ATOM   629  C CB  . PHE A 1 220 ? 109.885 140.507 142.020 1.00 46.86  ?  104 PHE E CB  1 
ATOM   630  C CG  . PHE A 1 220 ? 111.168 139.736 142.174 1.00 54.35  ?  104 PHE E CG  1 
ATOM   631  C CD1 . PHE A 1 220 ? 112.364 140.392 142.402 1.00 55.68  ?  104 PHE E CD1 1 
ATOM   632  C CD2 . PHE A 1 220 ? 111.167 138.350 142.143 1.00 54.08  ?  104 PHE E CD2 1 
ATOM   633  C CE1 . PHE A 1 220 ? 113.537 139.685 142.556 1.00 54.59  ?  104 PHE E CE1 1 
ATOM   634  C CE2 . PHE A 1 220 ? 112.340 137.638 142.304 1.00 54.90  ?  104 PHE E CE2 1 
ATOM   635  C CZ  . PHE A 1 220 ? 113.525 138.309 142.512 1.00 53.94  ?  104 PHE E CZ  1 
ATOM   636  N N   . PRO A 1 221 ? 110.406 139.947 138.895 1.00 46.02  ?  105 PRO E N   1 
ATOM   637  C CA  . PRO A 1 221 ? 111.249 139.615 137.735 1.00 41.86  ?  105 PRO E CA  1 
ATOM   638  C C   . PRO A 1 221 ? 111.337 140.731 136.710 1.00 50.26  ?  105 PRO E C   1 
ATOM   639  O O   . PRO A 1 221 ? 112.377 140.871 136.058 1.00 53.99  ?  105 PRO E O   1 
ATOM   640  C CB  . PRO A 1 221 ? 110.573 138.366 137.156 1.00 42.52  ?  105 PRO E CB  1 
ATOM   641  C CG  . PRO A 1 221 ? 109.857 137.770 138.299 1.00 49.34  ?  105 PRO E CG  1 
ATOM   642  C CD  . PRO A 1 221 ? 109.353 138.936 139.087 1.00 48.97  ?  105 PRO E CD  1 
ATOM   643  N N   . TYR A 1 222 ? 110.280 141.527 136.539 1.00 59.18  ?  106 TYR E N   1 
ATOM   644  C CA  . TYR A 1 222 ? 110.342 142.639 135.594 1.00 52.18  ?  106 TYR E CA  1 
ATOM   645  C C   . TYR A 1 222 ? 111.366 143.670 136.048 1.00 43.31  ?  106 TYR E C   1 
ATOM   646  O O   . TYR A 1 222 ? 112.162 144.176 135.245 1.00 44.19  ?  106 TYR E O   1 
ATOM   647  C CB  . TYR A 1 222 ? 108.954 143.267 135.440 1.00 59.39  ?  106 TYR E CB  1 
ATOM   648  C CG  . TYR A 1 222 ? 108.916 144.591 134.711 1.00 54.10  ?  106 TYR E CG  1 
ATOM   649  C CD1 . TYR A 1 222 ? 109.198 145.786 135.360 1.00 52.39  ?  106 TYR E CD1 1 
ATOM   650  C CD2 . TYR A 1 222 ? 108.523 144.650 133.382 1.00 51.40  ?  106 TYR E CD2 1 
ATOM   651  C CE1 . TYR A 1 222 ? 109.143 146.989 134.691 1.00 58.30  ?  106 TYR E CE1 1 
ATOM   652  C CE2 . TYR A 1 222 ? 108.470 145.844 132.707 1.00 48.81  ?  106 TYR E CE2 1 
ATOM   653  C CZ  . TYR A 1 222 ? 108.777 147.012 133.364 1.00 58.21  ?  106 TYR E CZ  1 
ATOM   654  O OH  . TYR A 1 222 ? 108.718 148.209 132.689 1.00 66.14  ?  106 TYR E OH  1 
ATOM   655  N N   . PHE A 1 223 ? 111.353 143.993 137.341 1.00 39.25  ?  107 PHE E N   1 
ATOM   656  C CA  . PHE A 1 223 ? 112.342 144.912 137.884 1.00 36.81  ?  107 PHE E CA  1 
ATOM   657  C C   . PHE A 1 223 ? 113.743 144.342 137.737 1.00 42.80  ?  107 PHE E C   1 
ATOM   658  O O   . PHE A 1 223 ? 114.685 145.071 137.410 1.00 46.78  ?  107 PHE E O   1 
ATOM   659  C CB  . PHE A 1 223 ? 112.030 145.206 139.349 1.00 41.52  ?  107 PHE E CB  1 
ATOM   660  C CG  . PHE A 1 223 ? 111.278 146.486 139.563 1.00 49.04  ?  107 PHE E CG  1 
ATOM   661  C CD1 . PHE A 1 223 ? 109.927 146.563 139.278 1.00 48.07  ?  107 PHE E CD1 1 
ATOM   662  C CD2 . PHE A 1 223 ? 111.919 147.610 140.054 1.00 51.58  ?  107 PHE E CD2 1 
ATOM   663  C CE1 . PHE A 1 223 ? 109.229 147.735 139.471 1.00 48.67  ?  107 PHE E CE1 1 
ATOM   664  C CE2 . PHE A 1 223 ? 111.226 148.787 140.251 1.00 49.59  ?  107 PHE E CE2 1 
ATOM   665  C CZ  . PHE A 1 223 ? 109.879 148.849 139.959 1.00 48.68  ?  107 PHE E CZ  1 
ATOM   666  N N   . THR A 1 224 ? 113.897 143.035 137.964 1.00 46.07  ?  108 THR E N   1 
ATOM   667  C CA  . THR A 1 224 ? 115.204 142.407 137.799 1.00 39.95  ?  108 THR E CA  1 
ATOM   668  C C   . THR A 1 224 ? 115.688 142.517 136.358 1.00 47.69  ?  108 THR E C   1 
ATOM   669  O O   . THR A 1 224 ? 116.854 142.832 136.104 1.00 55.12  ?  108 THR E O   1 
ATOM   670  C CB  . THR A 1 224 ? 115.146 140.943 138.233 1.00 36.94  ?  108 THR E CB  1 
ATOM   671  O OG1 . THR A 1 224 ? 115.140 140.867 139.663 1.00 49.99  ?  108 THR E OG1 1 
ATOM   672  C CG2 . THR A 1 224 ? 116.356 140.191 137.712 1.00 42.50  ?  108 THR E CG2 1 
ATOM   673  N N   . GLY A 1 225 ? 114.798 142.263 135.398 1.00 44.14  ?  109 GLY E N   1 
ATOM   674  C CA  . GLY A 1 225 ? 115.187 142.344 134.000 1.00 36.19  ?  109 GLY E CA  1 
ATOM   675  C C   . GLY A 1 225 ? 115.570 143.748 133.575 1.00 36.30  ?  109 GLY E C   1 
ATOM   676  O O   . GLY A 1 225 ? 116.565 143.944 132.869 1.00 44.25  ?  109 GLY E O   1 
ATOM   677  N N   . LEU A 1 226 ? 114.789 144.746 133.995 1.00 38.02  ?  110 LEU E N   1 
ATOM   678  C CA  . LEU A 1 226 ? 115.156 146.122 133.682 1.00 35.71  ?  110 LEU E CA  1 
ATOM   679  C C   . LEU A 1 226 ? 116.472 146.511 134.344 1.00 38.37  ?  110 LEU E C   1 
ATOM   680  O O   . LEU A 1 226 ? 117.294 147.207 133.733 1.00 48.27  ?  110 LEU E O   1 
ATOM   681  C CB  . LEU A 1 226 ? 114.048 147.082 134.105 1.00 42.79  ?  110 LEU E CB  1 
ATOM   682  C CG  . LEU A 1 226 ? 112.791 147.091 133.235 1.00 44.31  ?  110 LEU E CG  1 
ATOM   683  C CD1 . LEU A 1 226 ? 112.024 148.383 133.448 1.00 45.54  ?  110 LEU E CD1 1 
ATOM   684  C CD2 . LEU A 1 226 ? 113.123 146.887 131.766 1.00 42.58  ?  110 LEU E CD2 1 
ATOM   685  N N   . SER A 1 227 ? 116.691 146.065 135.583 1.00 28.26  ?  111 SER E N   1 
ATOM   686  C CA  . SER A 1 227 ? 117.949 146.342 136.263 1.00 29.18  ?  111 SER E CA  1 
ATOM   687  C C   . SER A 1 227 ? 119.119 145.710 135.527 1.00 36.25  ?  111 SER E C   1 
ATOM   688  O O   . SER A 1 227 ? 120.188 146.315 135.421 1.00 42.01  ?  111 SER E O   1 
ATOM   689  C CB  . SER A 1 227 ? 117.885 145.835 137.702 1.00 38.02  ?  111 SER E CB  1 
ATOM   690  O OG  . SER A 1 227 ? 116.716 146.299 138.353 1.00 44.98  ?  111 SER E OG  1 
ATOM   691  N N   . MET A 1 228 ? 118.937 144.493 135.014 1.00 38.19  ?  112 MET E N   1 
ATOM   692  C CA  . MET A 1 228 ? 120.010 143.843 134.269 1.00 39.17  ?  112 MET E CA  1 
ATOM   693  C C   . MET A 1 228 ? 120.277 144.533 132.940 1.00 38.79  ?  112 MET E C   1 
ATOM   694  O O   . MET A 1 228 ? 121.435 144.638 132.527 1.00 42.59  ?  112 MET E O   1 
ATOM   695  C CB  . MET A 1 228 ? 119.687 142.368 134.049 1.00 39.50  ?  112 MET E CB  1 
ATOM   696  C CG  . MET A 1 228 ? 119.586 141.577 135.333 1.00 37.06  ?  112 MET E CG  1 
ATOM   697  S SD  . MET A 1 228 ? 121.157 141.519 136.203 1.00 42.74  ?  112 MET E SD  1 
ATOM   698  C CE  . MET A 1 228 ? 120.842 140.186 137.345 1.00 44.38  ?  112 MET E CE  1 
ATOM   699  N N   . LEU A 1 229 ? 119.233 144.998 132.253 1.00 42.29  ?  113 LEU E N   1 
ATOM   700  C CA  . LEU A 1 229 ? 119.448 145.761 131.025 1.00 35.98  ?  113 LEU E CA  1 
ATOM   701  C C   . LEU A 1 229 ? 120.229 147.038 131.307 1.00 38.51  ?  113 LEU E C   1 
ATOM   702  O O   . LEU A 1 229 ? 121.181 147.375 130.590 1.00 43.45  ?  113 LEU E O   1 
ATOM   703  C CB  . LEU A 1 229 ? 118.109 146.083 130.365 1.00 41.37  ?  113 LEU E CB  1 
ATOM   704  C CG  . LEU A 1 229 ? 117.352 144.885 129.798 1.00 46.24  ?  113 LEU E CG  1 
ATOM   705  C CD1 . LEU A 1 229 ? 116.150 145.336 128.992 1.00 44.27  ?  113 LEU E CD1 1 
ATOM   706  C CD2 . LEU A 1 229 ? 118.287 144.063 128.939 1.00 49.37  ?  113 LEU E CD2 1 
ATOM   707  N N   . SER A 1 230 ? 119.843 147.757 132.363 1.00 29.42  ?  114 SER E N   1 
ATOM   708  C CA  . SER A 1 230 ? 120.570 148.965 132.736 1.00 18.55  ?  114 SER E CA  1 
ATOM   709  C C   . SER A 1 230 ? 122.006 148.646 133.127 1.00 25.87  ?  114 SER E C   1 
ATOM   710  O O   . SER A 1 230 ? 122.929 149.400 132.797 1.00 46.48  ?  114 SER E O   1 
ATOM   711  C CB  . SER A 1 230 ? 119.852 149.675 133.880 1.00 32.40  ?  114 SER E CB  1 
ATOM   712  O OG  . SER A 1 230 ? 120.737 150.545 134.559 1.00 36.46  ?  114 SER E OG  1 
ATOM   713  N N   . ALA A 1 231 ? 122.210 147.540 133.846 1.00 21.24  ?  115 ALA E N   1 
ATOM   714  C CA  . ALA A 1 231 ? 123.553 147.146 134.250 1.00 24.72  ?  115 ALA E CA  1 
ATOM   715  C C   . ALA A 1 231 ? 124.413 146.812 133.043 1.00 26.43  ?  115 ALA E C   1 
ATOM   716  O O   . ALA A 1 231 ? 125.582 147.197 132.985 1.00 23.83  ?  115 ALA E O   1 
ATOM   717  C CB  . ALA A 1 231 ? 123.486 145.957 135.207 1.00 29.79  ?  115 ALA E CB  1 
ATOM   718  N N   . ILE A 1 232 ? 123.849 146.106 132.063 1.00 30.21  ?  116 ILE E N   1 
ATOM   719  C CA  . ILE A 1 232 ? 124.584 145.804 130.839 1.00 18.82  ?  116 ILE E CA  1 
ATOM   720  C C   . ILE A 1 232 ? 124.963 147.089 130.118 1.00 29.51  ?  116 ILE E C   1 
ATOM   721  O O   . ILE A 1 232 ? 126.102 147.250 129.662 1.00 50.35  ?  116 ILE E O   1 
ATOM   722  C CB  . ILE A 1 232 ? 123.753 144.879 129.932 1.00 28.41  ?  116 ILE E CB  1 
ATOM   723  C CG1 . ILE A 1 232 ? 123.679 143.474 130.520 1.00 28.29  ?  116 ILE E CG1 1 
ATOM   724  C CG2 . ILE A 1 232 ? 124.337 144.837 128.532 1.00 38.65  ?  116 ILE E CG2 1 
ATOM   725  C CD1 . ILE A 1 232 ? 122.578 142.627 129.928 1.00 39.22  ?  116 ILE E CD1 1 
ATOM   726  N N   . SER A 1 233 ? 124.016 148.022 130.003 1.00 28.75  ?  117 SER E N   1 
ATOM   727  C CA  . SER A 1 233 ? 124.296 149.272 129.302 1.00 27.80  ?  117 SER E CA  1 
ATOM   728  C C   . SER A 1 233 ? 125.410 150.052 129.989 1.00 29.83  ?  117 SER E C   1 
ATOM   729  O O   . SER A 1 233 ? 126.390 150.454 129.347 1.00 45.91  ?  117 SER E O   1 
ATOM   730  C CB  . SER A 1 233 ? 123.025 150.113 129.207 1.00 37.57  ?  117 SER E CB  1 
ATOM   731  O OG  . SER A 1 233 ? 121.901 149.297 128.935 1.00 50.76  ?  117 SER E OG  1 
ATOM   732  N N   . THR A 1 234 ? 125.290 150.264 131.302 1.00 20.99  ?  118 THR E N   1 
ATOM   733  C CA  . THR A 1 234 ? 126.317 151.034 131.996 1.00 28.51  ?  118 THR E CA  1 
ATOM   734  C C   . THR A 1 234 ? 127.634 150.276 132.057 1.00 37.18  ?  118 THR E C   1 
ATOM   735  O O   . THR A 1 234 ? 128.700 150.896 132.097 1.00 42.30  ?  118 THR E O   1 
ATOM   736  C CB  . THR A 1 234 ? 125.865 151.412 133.408 1.00 31.83  ?  118 THR E CB  1 
ATOM   737  O OG1 . THR A 1 234 ? 126.911 152.144 134.057 1.00 38.44  ?  118 THR E OG1 1 
ATOM   738  C CG2 . THR A 1 234 ? 125.570 150.177 134.230 1.00 42.17  ?  118 THR E CG2 1 
ATOM   739  N N   . GLU A 1 235 ? 127.590 148.944 132.018 1.00 35.79  ?  119 GLU E N   1 
ATOM   740  C CA  . GLU A 1 235 ? 128.815 148.164 132.090 1.00 31.99  ?  119 GLU E CA  1 
ATOM   741  C C   . GLU A 1 235 ? 129.583 148.258 130.779 1.00 32.14  ?  119 GLU E C   1 
ATOM   742  O O   . GLU A 1 235 ? 130.808 148.418 130.777 1.00 37.45  ?  119 GLU E O   1 
ATOM   743  C CB  . GLU A 1 235 ? 128.473 146.710 132.415 1.00 31.20  ?  119 GLU E CB  1 
ATOM   744  C CG  . GLU A 1 235 ? 128.806 146.253 133.836 1.00 40.46  ?  119 GLU E CG  1 
ATOM   745  C CD  . GLU A 1 235 ? 130.180 146.659 134.318 1.00 48.85  ?  119 GLU E CD  1 
ATOM   746  O OE1 . GLU A 1 235 ? 131.100 146.759 133.492 1.00 46.95  ?  119 GLU E OE1 1 
ATOM   747  O OE2 . GLU A 1 235 ? 130.340 146.874 135.538 1.00 44.49  -1 119 GLU E OE2 1 
ATOM   748  N N   . ARG A 1 236 ? 128.870 148.177 129.652 1.00 30.62  ?  120 ARG E N   1 
ATOM   749  C CA  . ARG A 1 236 ? 129.491 148.422 128.356 1.00 22.31  ?  120 ARG E CA  1 
ATOM   750  C C   . ARG A 1 236 ? 130.024 149.846 128.265 1.00 26.53  ?  120 ARG E C   1 
ATOM   751  O O   . ARG A 1 236 ? 131.110 150.079 127.719 1.00 38.47  ?  120 ARG E O   1 
ATOM   752  C CB  . ARG A 1 236 ? 128.486 148.157 127.235 1.00 30.84  ?  120 ARG E CB  1 
ATOM   753  C CG  . ARG A 1 236 ? 128.146 146.691 127.001 1.00 31.99  ?  120 ARG E CG  1 
ATOM   754  C CD  . ARG A 1 236 ? 129.393 145.851 126.755 1.00 39.04  ?  120 ARG E CD  1 
ATOM   755  N NE  . ARG A 1 236 ? 129.245 144.988 125.588 1.00 44.75  ?  120 ARG E NE  1 
ATOM   756  C CZ  . ARG A 1 236 ? 130.255 144.437 124.928 1.00 40.89  ?  120 ARG E CZ  1 
ATOM   757  N NH1 . ARG A 1 236 ? 131.509 144.627 125.301 1.00 36.29  1  120 ARG E NH1 1 
ATOM   758  N NH2 . ARG A 1 236 ? 130.000 143.677 123.867 1.00 31.68  ?  120 ARG E NH2 1 
ATOM   759  N N   . CYS A 1 237 ? 129.269 150.815 128.789 1.00 26.23  ?  121 CYS E N   1 
ATOM   760  C CA  . CYS A 1 237 ? 129.739 152.197 128.777 1.00 24.67  ?  121 CYS E CA  1 
ATOM   761  C C   . CYS A 1 237 ? 131.029 152.349 129.572 1.00 31.78  ?  121 CYS E C   1 
ATOM   762  O O   . CYS A 1 237 ? 131.950 153.051 129.143 1.00 43.83  ?  121 CYS E O   1 
ATOM   763  C CB  . CYS A 1 237 ? 128.659 153.125 129.328 1.00 26.32  ?  121 CYS E CB  1 
ATOM   764  S SG  . CYS A 1 237 ? 129.229 154.808 129.642 1.00 47.35  ?  121 CYS E SG  1 
ATOM   765  N N   . LEU A 1 238 ? 131.113 151.704 130.738 1.00 36.89  ?  122 LEU E N   1 
ATOM   766  C CA  . LEU A 1 238 ? 132.330 151.772 131.541 1.00 34.61  ?  122 LEU E CA  1 
ATOM   767  C C   . LEU A 1 238 ? 133.486 151.050 130.862 1.00 30.26  ?  122 LEU E C   1 
ATOM   768  O O   . LEU A 1 238 ? 134.639 151.484 130.962 1.00 35.46  ?  122 LEU E O   1 
ATOM   769  C CB  . LEU A 1 238 ? 132.079 151.189 132.931 1.00 32.89  ?  122 LEU E CB  1 
ATOM   770  C CG  . LEU A 1 238 ? 131.149 151.981 133.852 1.00 41.44  ?  122 LEU E CG  1 
ATOM   771  C CD1 . LEU A 1 238 ? 130.931 151.241 135.160 1.00 41.27  ?  122 LEU E CD1 1 
ATOM   772  C CD2 . LEU A 1 238 ? 131.706 153.372 134.107 1.00 37.45  ?  122 LEU E CD2 1 
ATOM   773  N N   . SER A 1 239 ? 133.203 149.935 130.185 1.00 19.82  ?  123 SER E N   1 
ATOM   774  C CA  . SER A 1 239 ? 134.257 149.222 129.472 1.00 17.59  ?  123 SER E CA  1 
ATOM   775  C C   . SER A 1 239 ? 134.827 150.069 128.344 1.00 17.62  ?  123 SER E C   1 
ATOM   776  O O   . SER A 1 239 ? 136.042 150.074 128.117 1.00 28.80  ?  123 SER E O   1 
ATOM   777  C CB  . SER A 1 239 ? 133.723 147.899 128.928 1.00 23.47  ?  123 SER E CB  1 
ATOM   778  O OG  . SER A 1 239 ? 132.810 148.119 127.870 1.00 27.19  ?  123 SER E OG  1 
ATOM   779  N N   . VAL A 1 240 ? 133.966 150.779 127.618 1.00 26.23  ?  124 VAL E N   1 
ATOM   780  C CA  . VAL A 1 240 ? 134.439 151.644 126.542 1.00 23.38  ?  124 VAL E CA  1 
ATOM   781  C C   . VAL A 1 240 ? 135.159 152.870 127.096 1.00 20.92  ?  124 VAL E C   1 
ATOM   782  O O   . VAL A 1 240 ? 136.180 153.301 126.550 1.00 26.07  ?  124 VAL E O   1 
ATOM   783  C CB  . VAL A 1 240 ? 133.266 152.034 125.627 1.00 24.93  ?  124 VAL E CB  1 
ATOM   784  C CG1 . VAL A 1 240 ? 133.702 153.075 124.615 1.00 23.94  ?  124 VAL E CG1 1 
ATOM   785  C CG2 . VAL A 1 240 ? 132.727 150.800 124.923 1.00 32.04  ?  124 VAL E CG2 1 
ATOM   786  N N   . LEU A 1 241 ? 134.646 153.450 128.183 1.00 21.24  ?  125 LEU E N   1 
ATOM   787  C CA  . LEU A 1 241 ? 135.240 154.667 128.729 1.00 20.26  ?  125 LEU E CA  1 
ATOM   788  C C   . LEU A 1 241 ? 136.655 154.418 129.231 1.00 29.78  ?  125 LEU E C   1 
ATOM   789  O O   . LEU A 1 241 ? 137.586 155.153 128.884 1.00 37.63  ?  125 LEU E O   1 
ATOM   790  C CB  . LEU A 1 241 ? 134.364 155.219 129.853 1.00 32.75  ?  125 LEU E CB  1 
ATOM   791  C CG  . LEU A 1 241 ? 133.151 156.058 129.451 1.00 41.56  ?  125 LEU E CG  1 
ATOM   792  C CD1 . LEU A 1 241 ? 132.460 156.613 130.684 1.00 41.37  ?  125 LEU E CD1 1 
ATOM   793  C CD2 . LEU A 1 241 ? 133.561 157.181 128.514 1.00 32.68  ?  125 LEU E CD2 1 
ATOM   794  N N   . TRP A 1 242 ? 136.837 153.389 130.057 1.00 30.43  ?  126 TRP E N   1 
ATOM   795  C CA  . TRP A 1 242 ? 138.149 153.012 130.582 1.00 29.15  ?  126 TRP E CA  1 
ATOM   796  C C   . TRP A 1 242 ? 138.370 151.535 130.296 1.00 37.96  ?  126 TRP E C   1 
ATOM   797  O O   . TRP A 1 242 ? 137.981 150.671 131.094 1.00 47.92  ?  126 TRP E O   1 
ATOM   798  C CB  . TRP A 1 242 ? 138.259 153.309 132.075 1.00 29.87  ?  126 TRP E CB  1 
ATOM   799  C CG  . TRP A 1 242 ? 137.930 154.723 132.423 1.00 41.22  ?  126 TRP E CG  1 
ATOM   800  C CD1 . TRP A 1 242 ? 138.652 155.833 132.103 1.00 41.26  ?  126 TRP E CD1 1 
ATOM   801  C CD2 . TRP A 1 242 ? 136.794 155.181 133.163 1.00 39.74  ?  126 TRP E CD2 1 
ATOM   802  N NE1 . TRP A 1 242 ? 138.035 156.956 132.596 1.00 37.75  ?  126 TRP E NE1 1 
ATOM   803  C CE2 . TRP A 1 242 ? 136.892 156.582 133.252 1.00 28.76  ?  126 TRP E CE2 1 
ATOM   804  C CE3 . TRP A 1 242 ? 135.703 154.543 133.759 1.00 39.78  ?  126 TRP E CE3 1 
ATOM   805  C CZ2 . TRP A 1 242 ? 135.942 157.355 133.911 1.00 33.61  ?  126 TRP E CZ2 1 
ATOM   806  C CZ3 . TRP A 1 242 ? 134.761 155.311 134.411 1.00 32.64  ?  126 TRP E CZ3 1 
ATOM   807  C CH2 . TRP A 1 242 ? 134.886 156.702 134.482 1.00 43.83  ?  126 TRP E CH2 1 
ATOM   808  N N   . PRO A 1 243 ? 138.983 151.204 129.158 1.00 12.64  ?  127 PRO E N   1 
ATOM   809  C CA  . PRO A 1 243 ? 139.194 149.786 128.838 1.00 9.77   ?  127 PRO E CA  1 
ATOM   810  C C   . PRO A 1 243 ? 140.305 149.151 129.649 1.00 25.73  ?  127 PRO E C   1 
ATOM   811  O O   . PRO A 1 243 ? 140.213 147.963 129.980 1.00 41.19  ?  127 PRO E O   1 
ATOM   812  C CB  . PRO A 1 243 ? 139.534 149.808 127.340 1.00 27.25  ?  127 PRO E CB  1 
ATOM   813  C CG  . PRO A 1 243 ? 139.308 151.232 126.882 1.00 26.74  ?  127 PRO E CG  1 
ATOM   814  C CD  . PRO A 1 243 ? 139.471 152.084 128.089 1.00 17.58  ?  127 PRO E CD  1 
ATOM   815  N N   . ILE A 1 244 ? 141.358 149.904 129.973 1.00 16.16  ?  128 ILE E N   1 
ATOM   816  C CA  . ILE A 1 244 ? 142.464 149.346 130.743 1.00 14.12  ?  128 ILE E CA  1 
ATOM   817  C C   . ILE A 1 244 ? 141.992 148.938 132.132 1.00 33.52  ?  128 ILE E C   1 
ATOM   818  O O   . ILE A 1 244 ? 142.297 147.840 132.611 1.00 43.89  ?  128 ILE E O   1 
ATOM   819  C CB  . ILE A 1 244 ? 143.628 150.348 130.813 1.00 27.79  ?  128 ILE E CB  1 
ATOM   820  C CG1 . ILE A 1 244 ? 144.052 150.762 129.405 1.00 29.62  ?  128 ILE E CG1 1 
ATOM   821  C CG2 . ILE A 1 244 ? 144.802 149.748 131.568 1.00 31.66  ?  128 ILE E CG2 1 
ATOM   822  C CD1 . ILE A 1 244 ? 144.619 149.627 128.585 1.00 36.23  ?  128 ILE E CD1 1 
ATOM   823  N N   . TRP A 1 245 ? 141.238 149.815 132.801 1.00 27.60  ?  129 TRP E N   1 
ATOM   824  C CA  . TRP A 1 245 ? 140.701 149.466 134.112 1.00 14.49  ?  129 TRP E CA  1 
ATOM   825  C C   . TRP A 1 245 ? 139.754 148.282 134.014 1.00 12.44  ?  129 TRP E C   1 
ATOM   826  O O   . TRP A 1 245 ? 139.763 147.395 134.875 1.00 47.19  ?  129 TRP E O   1 
ATOM   827  C CB  . TRP A 1 245 ? 139.981 150.660 134.739 1.00 22.77  ?  129 TRP E CB  1 
ATOM   828  C CG  . TRP A 1 245 ? 139.210 150.286 135.979 1.00 25.25  ?  129 TRP E CG  1 
ATOM   829  C CD1 . TRP A 1 245 ? 139.674 150.288 137.261 1.00 29.17  ?  129 TRP E CD1 1 
ATOM   830  C CD2 . TRP A 1 245 ? 137.849 149.837 136.048 1.00 27.00  ?  129 TRP E CD2 1 
ATOM   831  N NE1 . TRP A 1 245 ? 138.689 149.876 138.123 1.00 30.56  ?  129 TRP E NE1 1 
ATOM   832  C CE2 . TRP A 1 245 ? 137.559 149.592 137.403 1.00 23.83  ?  129 TRP E CE2 1 
ATOM   833  C CE3 . TRP A 1 245 ? 136.849 149.622 135.097 1.00 30.13  ?  129 TRP E CE3 1 
ATOM   834  C CZ2 . TRP A 1 245 ? 136.313 149.144 137.829 1.00 22.29  ?  129 TRP E CZ2 1 
ATOM   835  C CZ3 . TRP A 1 245 ? 135.613 149.177 135.523 1.00 29.38  ?  129 TRP E CZ3 1 
ATOM   836  C CH2 . TRP A 1 245 ? 135.356 148.943 136.876 1.00 20.68  ?  129 TRP E CH2 1 
ATOM   837  N N   . TYR A 1 246 ? 138.920 148.258 132.977 1.00 0.00   ?  130 TYR E N   1 
ATOM   838  C CA  . TYR A 1 246 ? 137.981 147.157 132.805 1.00 11.02  ?  130 TYR E CA  1 
ATOM   839  C C   . TYR A 1 246 ? 138.694 145.823 132.665 1.00 28.56  ?  130 TYR E C   1 
ATOM   840  O O   . TYR A 1 246 ? 138.331 144.843 133.326 1.00 34.38  ?  130 TYR E O   1 
ATOM   841  C CB  . TYR A 1 246 ? 137.107 147.409 131.583 1.00 14.29  ?  130 TYR E CB  1 
ATOM   842  C CG  . TYR A 1 246 ? 135.851 146.590 131.579 1.00 12.76  ?  130 TYR E CG  1 
ATOM   843  C CD1 . TYR A 1 246 ? 134.750 146.973 132.316 1.00 16.85  ?  130 TYR E CD1 1 
ATOM   844  C CD2 . TYR A 1 246 ? 135.772 145.419 130.841 1.00 24.54  ?  130 TYR E CD2 1 
ATOM   845  C CE1 . TYR A 1 246 ? 133.611 146.221 132.313 1.00 10.94  ?  130 TYR E CE1 1 
ATOM   846  C CE2 . TYR A 1 246 ? 134.629 144.659 130.833 1.00 23.08  ?  130 TYR E CE2 1 
ATOM   847  C CZ  . TYR A 1 246 ? 133.549 145.067 131.573 1.00 17.54  ?  130 TYR E CZ  1 
ATOM   848  O OH  . TYR A 1 246 ? 132.397 144.318 131.576 1.00 25.86  ?  130 TYR E OH  1 
ATOM   849  N N   . ARG A 1 247 ? 139.709 145.761 131.812 1.00 29.40  ?  131 ARG E N   1 
ATOM   850  C CA  . ARG A 1 247 ? 140.336 144.485 131.503 1.00 24.19  ?  131 ARG E CA  1 
ATOM   851  C C   . ARG A 1 247 ? 141.355 144.065 132.553 1.00 26.32  ?  131 ARG E C   1 
ATOM   852  O O   . ARG A 1 247 ? 141.518 142.864 132.798 1.00 38.77  ?  131 ARG E O   1 
ATOM   853  C CB  . ARG A 1 247 ? 140.982 144.553 130.116 1.00 20.29  ?  131 ARG E CB  1 
ATOM   854  C CG  . ARG A 1 247 ? 142.020 143.490 129.832 1.00 32.44  ?  131 ARG E CG  1 
ATOM   855  C CD  . ARG A 1 247 ? 141.983 143.097 128.368 1.00 35.13  ?  131 ARG E CD  1 
ATOM   856  N NE  . ARG A 1 247 ? 140.621 143.104 127.846 1.00 38.23  ?  131 ARG E NE  1 
ATOM   857  C CZ  . ARG A 1 247 ? 139.807 142.059 127.863 1.00 32.09  ?  131 ARG E CZ  1 
ATOM   858  N NH1 . ARG A 1 247 ? 140.182 140.899 128.377 1.00 32.23  1  131 ARG E NH1 1 
ATOM   859  N NH2 . ARG A 1 247 ? 138.585 142.179 127.352 1.00 28.77  ?  131 ARG E NH2 1 
ATOM   860  N N   . CYS A 1 248 ? 142.015 145.018 133.208 1.00 12.36  ?  132 CYS E N   1 
ATOM   861  C CA  . CYS A 1 248 ? 143.066 144.706 134.168 1.00 14.93  ?  132 CYS E CA  1 
ATOM   862  C C   . CYS A 1 248 ? 142.613 144.884 135.613 1.00 32.66  ?  132 CYS E C   1 
ATOM   863  O O   . CYS A 1 248 ? 142.689 143.944 136.410 1.00 43.13  ?  132 CYS E O   1 
ATOM   864  C CB  . CYS A 1 248 ? 144.295 145.580 133.890 1.00 12.53  ?  132 CYS E CB  1 
ATOM   865  S SG  . CYS A 1 248 ? 144.824 145.592 132.164 1.00 28.92  ?  132 CYS E SG  1 
ATOM   866  N N   . ARG A 1 249 ? 142.127 146.071 135.965 1.00 31.02  ?  133 ARG E N   1 
ATOM   867  C CA  . ARG A 1 249 ? 141.941 146.448 137.360 1.00 26.35  ?  133 ARG E CA  1 
ATOM   868  C C   . ARG A 1 249 ? 140.545 146.150 137.898 1.00 25.03  ?  133 ARG E C   1 
ATOM   869  O O   . ARG A 1 249 ? 140.245 146.533 139.032 1.00 29.69  ?  133 ARG E O   1 
ATOM   870  C CB  . ARG A 1 249 ? 142.263 147.932 137.550 1.00 24.14  ?  133 ARG E CB  1 
ATOM   871  C CG  . ARG A 1 249 ? 143.299 148.469 136.580 1.00 25.19  ?  133 ARG E CG  1 
ATOM   872  C CD  . ARG A 1 249 ? 143.729 149.872 136.964 1.00 28.52  ?  133 ARG E CD  1 
ATOM   873  N NE  . ARG A 1 249 ? 144.417 150.553 135.874 1.00 30.99  ?  133 ARG E NE  1 
ATOM   874  C CZ  . ARG A 1 249 ? 144.830 151.812 135.922 1.00 38.80  ?  133 ARG E CZ  1 
ATOM   875  N NH1 . ARG A 1 249 ? 144.642 152.560 136.996 1.00 35.70  1  133 ARG E NH1 1 
ATOM   876  N NH2 . ARG A 1 249 ? 145.449 152.333 134.866 1.00 37.66  ?  133 ARG E NH2 1 
ATOM   877  N N   . ARG A 1 250 ? 139.688 145.491 137.129 1.00 17.06  ?  134 ARG E N   1 
ATOM   878  C CA  . ARG A 1 250 ? 138.403 145.086 137.674 1.00 21.55  ?  134 ARG E CA  1 
ATOM   879  C C   . ARG A 1 250 ? 138.598 143.926 138.648 1.00 47.18  ?  134 ARG E C   1 
ATOM   880  O O   . ARG A 1 250 ? 139.477 143.084 138.442 1.00 58.22  ?  134 ARG E O   1 
ATOM   881  C CB  . ARG A 1 250 ? 137.439 144.680 136.563 1.00 17.28  ?  134 ARG E CB  1 
ATOM   882  C CG  . ARG A 1 250 ? 136.040 145.238 136.749 1.00 27.42  ?  134 ARG E CG  1 
ATOM   883  C CD  . ARG A 1 250 ? 135.118 144.825 135.621 1.00 38.19  ?  134 ARG E CD  1 
ATOM   884  N NE  . ARG A 1 250 ? 134.603 143.473 135.800 1.00 34.19  ?  134 ARG E NE  1 
ATOM   885  C CZ  . ARG A 1 250 ? 133.333 143.184 136.045 1.00 34.74  ?  134 ARG E CZ  1 
ATOM   886  N NH1 . ARG A 1 250 ? 132.417 144.131 136.156 1.00 33.58  1  134 ARG E NH1 1 
ATOM   887  N NH2 . ARG A 1 250 ? 132.973 141.911 136.181 1.00 35.15  ?  134 ARG E NH2 1 
ATOM   888  N N   . PRO A 1 251 ? 137.807 143.862 139.724 1.00 48.45  ?  135 PRO E N   1 
ATOM   889  C CA  . PRO A 1 251 ? 137.982 142.788 140.714 1.00 41.30  ?  135 PRO E CA  1 
ATOM   890  C C   . PRO A 1 251 ? 137.674 141.395 140.183 1.00 44.95  ?  135 PRO E C   1 
ATOM   891  O O   . PRO A 1 251 ? 137.900 140.404 140.884 1.00 53.99  ?  135 PRO E O   1 
ATOM   892  C CB  . PRO A 1 251 ? 137.000 143.182 141.830 1.00 43.36  ?  135 PRO E CB  1 
ATOM   893  C CG  . PRO A 1 251 ? 136.123 144.244 141.216 1.00 42.42  ?  135 PRO E CG  1 
ATOM   894  C CD  . PRO A 1 251 ? 137.025 144.966 140.290 1.00 51.03  ?  135 PRO E CD  1 
ATOM   895  N N   . THR A 1 252 ? 137.141 141.311 138.961 1.00 51.14  ?  136 THR E N   1 
ATOM   896  C CA  . THR A 1 252 ? 136.813 140.050 138.294 1.00 58.81  ?  136 THR E CA  1 
ATOM   897  C C   . THR A 1 252 ? 135.724 139.271 139.025 1.00 62.03  ?  136 THR E C   1 
ATOM   898  O O   . THR A 1 252 ? 135.399 138.143 138.640 1.00 68.63  ?  136 THR E O   1 
ATOM   899  C CB  . THR A 1 252 ? 138.057 139.167 138.120 1.00 60.79  ?  136 THR E CB  1 
ATOM   900  O OG1 . THR A 1 252 ? 138.371 138.520 139.360 1.00 52.70  ?  136 THR E OG1 1 
ATOM   901  C CG2 . THR A 1 252 ? 139.254 139.981 137.632 1.00 57.49  ?  136 THR E CG2 1 
ATOM   902  N N   . HIS A 1 253 ? 135.156 139.857 140.079 1.00 52.05  ?  137 HIS E N   1 
ATOM   903  C CA  . HIS A 1 253 ? 133.968 139.293 140.706 1.00 49.37  ?  137 HIS E CA  1 
ATOM   904  C C   . HIS A 1 253 ? 132.931 140.369 140.993 1.00 51.68  ?  137 HIS E C   1 
ATOM   905  O O   . HIS A 1 253 ? 131.934 140.082 141.667 1.00 53.83  ?  137 HIS E O   1 
ATOM   906  C CB  . HIS A 1 253 ? 134.319 138.543 141.999 1.00 47.27  ?  137 HIS E CB  1 
ATOM   907  C CG  . HIS A 1 253 ? 135.102 139.355 142.984 1.00 55.03  ?  137 HIS E CG  1 
ATOM   908  N ND1 . HIS A 1 253 ? 134.582 140.464 143.616 1.00 57.33  ?  137 HIS E ND1 1 
ATOM   909  C CD2 . HIS A 1 253 ? 136.363 139.211 143.456 1.00 53.05  ?  137 HIS E CD2 1 
ATOM   910  C CE1 . HIS A 1 253 ? 135.491 140.972 144.429 1.00 54.08  ?  137 HIS E CE1 1 
ATOM   911  N NE2 . HIS A 1 253 ? 136.581 140.231 144.350 1.00 55.26  ?  137 HIS E NE2 1 
ATOM   912  N N   . LEU A 1 254 ? 133.140 141.596 140.508 1.00 43.83  ?  138 LEU E N   1 
ATOM   913  C CA  . LEU A 1 254 ? 132.162 142.659 140.699 1.00 37.56  ?  138 LEU E CA  1 
ATOM   914  C C   . LEU A 1 254 ? 130.851 142.330 140.002 1.00 36.28  ?  138 LEU E C   1 
ATOM   915  O O   . LEU A 1 254 ? 129.789 142.781 140.439 1.00 38.51  ?  138 LEU E O   1 
ATOM   916  C CB  . LEU A 1 254 ? 132.750 143.984 140.199 1.00 39.13  ?  138 LEU E CB  1 
ATOM   917  C CG  . LEU A 1 254 ? 132.102 145.377 140.245 1.00 43.20  ?  138 LEU E CG  1 
ATOM   918  C CD1 . LEU A 1 254 ? 133.106 146.385 139.715 1.00 45.93  ?  138 LEU E CD1 1 
ATOM   919  C CD2 . LEU A 1 254 ? 130.814 145.506 139.446 1.00 47.63  ?  138 LEU E CD2 1 
ATOM   920  N N   . SER A 1 255 ? 130.903 141.544 138.926 1.00 43.09  ?  139 SER E N   1 
ATOM   921  C CA  . SER A 1 255 ? 129.683 141.188 138.210 1.00 42.07  ?  139 SER E CA  1 
ATOM   922  C C   . SER A 1 255 ? 128.718 140.431 139.113 1.00 38.91  ?  139 SER E C   1 
ATOM   923  O O   . SER A 1 255 ? 127.533 140.766 139.190 1.00 44.64  ?  139 SER E O   1 
ATOM   924  C CB  . SER A 1 255 ? 130.025 140.360 136.973 1.00 48.88  ?  139 SER E CB  1 
ATOM   925  O OG  . SER A 1 255 ? 128.873 139.714 136.463 1.00 41.10  ?  139 SER E OG  1 
ATOM   926  N N   . ALA A 1 256 ? 129.214 139.414 139.820 1.00 42.28  ?  140 ALA E N   1 
ATOM   927  C CA  . ALA A 1 256 ? 128.349 138.641 140.707 1.00 43.85  ?  140 ALA E CA  1 
ATOM   928  C C   . ALA A 1 256 ? 127.851 139.485 141.873 1.00 45.58  ?  140 ALA E C   1 
ATOM   929  O O   . ALA A 1 256 ? 126.689 139.366 142.281 1.00 46.96  ?  140 ALA E O   1 
ATOM   930  C CB  . ALA A 1 256 ? 129.090 137.406 141.215 1.00 41.21  ?  140 ALA E CB  1 
ATOM   931  N N   . VAL A 1 257 ? 128.713 140.341 142.424 1.00 39.19  ?  141 VAL E N   1 
ATOM   932  C CA  . VAL A 1 257 ? 128.313 141.177 143.554 1.00 37.50  ?  141 VAL E CA  1 
ATOM   933  C C   . VAL A 1 257 ? 127.203 142.135 143.141 1.00 42.20  ?  141 VAL E C   1 
ATOM   934  O O   . VAL A 1 257 ? 126.182 142.262 143.825 1.00 52.26  ?  141 VAL E O   1 
ATOM   935  C CB  . VAL A 1 257 ? 129.528 141.934 144.118 1.00 42.99  ?  141 VAL E CB  1 
ATOM   936  C CG1 . VAL A 1 257 ? 129.093 142.887 145.217 1.00 36.65  ?  141 VAL E CG1 1 
ATOM   937  C CG2 . VAL A 1 257 ? 130.566 140.953 144.637 1.00 49.19  ?  141 VAL E CG2 1 
ATOM   938  N N   . VAL A 1 258 ? 127.380 142.818 142.009 1.00 44.02  ?  142 VAL E N   1 
ATOM   939  C CA  . VAL A 1 258 ? 126.352 143.753 141.567 1.00 42.34  ?  142 VAL E CA  1 
ATOM   940  C C   . VAL A 1 258 ? 125.100 143.005 141.132 1.00 42.10  ?  142 VAL E C   1 
ATOM   941  O O   . VAL A 1 258 ? 123.988 143.514 141.286 1.00 45.66  ?  142 VAL E O   1 
ATOM   942  C CB  . VAL A 1 258 ? 126.886 144.674 140.455 1.00 39.30  ?  142 VAL E CB  1 
ATOM   943  C CG1 . VAL A 1 258 ? 127.046 143.918 139.161 1.00 46.16  ?  142 VAL E CG1 1 
ATOM   944  C CG2 . VAL A 1 258 ? 125.960 145.864 140.267 1.00 43.62  ?  142 VAL E CG2 1 
ATOM   945  N N   . CYS A 1 259 ? 125.246 141.786 140.610 1.00 40.96  ?  143 CYS E N   1 
ATOM   946  C CA  . CYS A 1 259 ? 124.077 140.990 140.261 1.00 40.38  ?  143 CYS E CA  1 
ATOM   947  C C   . CYS A 1 259 ? 123.248 140.662 141.495 1.00 42.83  ?  143 CYS E C   1 
ATOM   948  O O   . CYS A 1 259 ? 122.021 140.812 141.492 1.00 51.36  ?  143 CYS E O   1 
ATOM   949  C CB  . CYS A 1 259 ? 124.516 139.712 139.547 1.00 46.88  ?  143 CYS E CB  1 
ATOM   950  S SG  . CYS A 1 259 ? 123.213 138.483 139.363 1.00 61.77  ?  143 CYS E SG  1 
ATOM   951  N N   . VAL A 1 260 ? 123.904 140.217 142.570 1.00 33.14  ?  144 VAL E N   1 
ATOM   952  C CA  . VAL A 1 260 ? 123.147 139.875 143.769 1.00 37.64  ?  144 VAL E CA  1 
ATOM   953  C C   . VAL A 1 260 ? 122.593 141.130 144.435 1.00 38.94  ?  144 VAL E C   1 
ATOM   954  O O   . VAL A 1 260 ? 121.506 141.093 145.022 1.00 48.56  ?  144 VAL E O   1 
ATOM   955  C CB  . VAL A 1 260 ? 123.988 139.022 144.739 1.00 46.61  ?  144 VAL E CB  1 
ATOM   956  C CG1 . VAL A 1 260 ? 124.509 137.780 144.032 1.00 40.83  ?  144 VAL E CG1 1 
ATOM   957  C CG2 . VAL A 1 260 ? 125.128 139.820 145.339 1.00 50.65  ?  144 VAL E CG2 1 
ATOM   958  N N   . LEU A 1 261 ? 123.299 142.263 144.343 1.00 33.86  ?  145 LEU E N   1 
ATOM   959  C CA  . LEU A 1 261 ? 122.730 143.512 144.848 1.00 35.52  ?  145 LEU E CA  1 
ATOM   960  C C   . LEU A 1 261 ? 121.489 143.916 144.060 1.00 45.80  ?  145 LEU E C   1 
ATOM   961  O O   . LEU A 1 261 ? 120.500 144.375 144.642 1.00 46.65  ?  145 LEU E O   1 
ATOM   962  C CB  . LEU A 1 261 ? 123.768 144.634 144.820 1.00 43.06  ?  145 LEU E CB  1 
ATOM   963  C CG  . LEU A 1 261 ? 125.052 144.466 145.634 1.00 50.68  ?  145 LEU E CG  1 
ATOM   964  C CD1 . LEU A 1 261 ? 125.666 145.820 145.942 1.00 45.81  ?  145 LEU E CD1 1 
ATOM   965  C CD2 . LEU A 1 261 ? 124.784 143.699 146.919 1.00 46.24  ?  145 LEU E CD2 1 
ATOM   966  N N   . LEU A 1 262 ? 121.522 143.760 142.734 1.00 55.54  ?  146 LEU E N   1 
ATOM   967  C CA  . LEU A 1 262 ? 120.349 144.068 141.922 1.00 47.51  ?  146 LEU E CA  1 
ATOM   968  C C   . LEU A 1 262 ? 119.190 143.142 142.257 1.00 50.58  ?  146 LEU E C   1 
ATOM   969  O O   . LEU A 1 262 ? 118.041 143.585 142.352 1.00 55.50  ?  146 LEU E O   1 
ATOM   970  C CB  . LEU A 1 262 ? 120.691 143.980 140.436 1.00 39.38  ?  146 LEU E CB  1 
ATOM   971  C CG  . LEU A 1 262 ? 121.621 145.064 139.893 1.00 49.75  ?  146 LEU E CG  1 
ATOM   972  C CD1 . LEU A 1 262 ? 121.733 144.965 138.383 1.00 48.10  ?  146 LEU E CD1 1 
ATOM   973  C CD2 . LEU A 1 262 ? 121.131 146.440 140.307 1.00 57.12  ?  146 LEU E CD2 1 
ATOM   974  N N   . TRP A 1 263 ? 119.470 141.851 142.447 1.00 42.18  ?  147 TRP E N   1 
ATOM   975  C CA  . TRP A 1 263 ? 118.412 140.922 142.834 1.00 37.26  ?  147 TRP E CA  1 
ATOM   976  C C   . TRP A 1 263 ? 117.821 141.300 144.187 1.00 38.59  ?  147 TRP E C   1 
ATOM   977  O O   . TRP A 1 263 ? 116.596 141.288 144.365 1.00 43.63  ?  147 TRP E O   1 
ATOM   978  C CB  . TRP A 1 263 ? 118.951 139.493 142.868 1.00 40.13  ?  147 TRP E CB  1 
ATOM   979  C CG  . TRP A 1 263 ? 119.032 138.833 141.527 1.00 34.42  ?  147 TRP E CG  1 
ATOM   980  C CD1 . TRP A 1 263 ? 120.137 138.712 140.743 1.00 35.58  ?  147 TRP E CD1 1 
ATOM   981  C CD2 . TRP A 1 263 ? 117.967 138.193 140.817 1.00 33.27  ?  147 TRP E CD2 1 
ATOM   982  N NE1 . TRP A 1 263 ? 119.830 138.041 139.588 1.00 38.55  ?  147 TRP E NE1 1 
ATOM   983  C CE2 . TRP A 1 263 ? 118.502 137.711 139.608 1.00 34.94  ?  147 TRP E CE2 1 
ATOM   984  C CE3 . TRP A 1 263 ? 116.613 137.981 141.086 1.00 39.30  ?  147 TRP E CE3 1 
ATOM   985  C CZ2 . TRP A 1 263 ? 117.732 137.031 138.670 1.00 39.46  ?  147 TRP E CZ2 1 
ATOM   986  C CZ3 . TRP A 1 263 ? 115.849 137.306 140.152 1.00 43.57  ?  147 TRP E CZ3 1 
ATOM   987  C CH2 . TRP A 1 263 ? 116.411 136.839 138.960 1.00 44.60  ?  147 TRP E CH2 1 
ATOM   988  N N   . GLY A 1 264 ? 118.676 141.653 145.148 1.00 49.01  ?  148 GLY E N   1 
ATOM   989  C CA  . GLY A 1 264 ? 118.186 142.038 146.461 1.00 50.37  ?  148 GLY E CA  1 
ATOM   990  C C   . GLY A 1 264 ? 117.355 143.305 146.428 1.00 51.49  ?  148 GLY E C   1 
ATOM   991  O O   . GLY A 1 264 ? 116.331 143.404 147.107 1.00 60.37  ?  148 GLY E O   1 
ATOM   992  N N   . LEU A 1 265 ? 117.785 144.293 145.641 1.00 43.92  ?  149 LEU E N   1 
ATOM   993  C CA  . LEU A 1 265 ? 117.004 145.515 145.494 1.00 44.53  ?  149 LEU E CA  1 
ATOM   994  C C   . LEU A 1 265 ? 115.735 145.282 144.689 1.00 43.94  ?  149 LEU E C   1 
ATOM   995  O O   . LEU A 1 265 ? 114.799 146.082 144.786 1.00 44.29  ?  149 LEU E O   1 
ATOM   996  C CB  . LEU A 1 265 ? 117.848 146.608 144.837 1.00 48.88  ?  149 LEU E CB  1 
ATOM   997  C CG  . LEU A 1 265 ? 118.612 147.567 145.757 1.00 54.23  ?  149 LEU E CG  1 
ATOM   998  C CD1 . LEU A 1 265 ? 117.720 148.716 146.188 1.00 50.50  ?  149 LEU E CD1 1 
ATOM   999  C CD2 . LEU A 1 265 ? 119.184 146.850 146.972 1.00 55.97  ?  149 LEU E CD2 1 
ATOM   1000 N N   . SER A 1 266 ? 115.690 144.217 143.888 1.00 52.75  ?  150 SER E N   1 
ATOM   1001 C CA  . SER A 1 266 ? 114.454 143.838 143.215 1.00 56.28  ?  150 SER E CA  1 
ATOM   1002 C C   . SER A 1 266 ? 113.487 143.158 144.175 1.00 57.08  ?  150 SER E C   1 
ATOM   1003 O O   . SER A 1 266 ? 112.267 143.274 144.014 1.00 61.20  ?  150 SER E O   1 
ATOM   1004 C CB  . SER A 1 266 ? 114.764 142.932 142.025 1.00 56.33  ?  150 SER E CB  1 
ATOM   1005 O OG  . SER A 1 266 ? 115.878 143.416 141.295 1.00 59.83  ?  150 SER E OG  1 
ATOM   1006 N N   . LEU A 1 267 ? 114.009 142.432 145.171 1.00 62.25  ?  151 LEU E N   1 
ATOM   1007 C CA  . LEU A 1 267 ? 113.160 142.029 146.289 1.00 61.52  ?  151 LEU E CA  1 
ATOM   1008 C C   . LEU A 1 267 ? 112.544 143.251 146.954 1.00 64.70  ?  151 LEU E C   1 
ATOM   1009 O O   . LEU A 1 267 ? 111.339 143.282 147.227 1.00 66.75  ?  151 LEU E O   1 
ATOM   1010 C CB  . LEU A 1 267 ? 113.950 141.216 147.318 1.00 62.73  ?  151 LEU E CB  1 
ATOM   1011 C CG  . LEU A 1 267 ? 115.079 140.264 146.925 1.00 66.73  ?  151 LEU E CG  1 
ATOM   1012 C CD1 . LEU A 1 267 ? 115.539 139.473 148.136 1.00 64.51  ?  151 LEU E CD1 1 
ATOM   1013 C CD2 . LEU A 1 267 ? 114.595 139.307 145.856 1.00 63.55  ?  151 LEU E CD2 1 
ATOM   1014 N N   . LEU A 1 268 ? 113.358 144.270 147.213 1.00 65.16  ?  152 LEU E N   1 
ATOM   1015 C CA  . LEU A 1 268 ? 112.850 145.554 147.656 1.00 60.95  ?  152 LEU E CA  1 
ATOM   1016 C C   . LEU A 1 268 ? 112.161 146.257 146.487 1.00 63.42  ?  152 LEU E C   1 
ATOM   1017 O O   . LEU A 1 268 ? 112.134 145.762 145.357 1.00 61.12  ?  152 LEU E O   1 
ATOM   1018 C CB  . LEU A 1 268 ? 113.991 146.403 148.220 1.00 59.81  ?  152 LEU E CB  1 
ATOM   1019 C CG  . LEU A 1 268 ? 113.694 147.588 149.143 1.00 60.08  ?  152 LEU E CG  1 
ATOM   1020 C CD1 . LEU A 1 268 ? 112.740 147.182 150.252 1.00 60.33  ?  152 LEU E CD1 1 
ATOM   1021 C CD2 . LEU A 1 268 ? 114.984 148.157 149.717 1.00 61.89  ?  152 LEU E CD2 1 
ATOM   1022 N N   . PHE A 1 269 ? 111.572 147.416 146.775 1.00 70.41  ?  153 PHE E N   1 
ATOM   1023 C CA  . PHE A 1 269 ? 110.879 148.234 145.782 1.00 70.09  ?  153 PHE E CA  1 
ATOM   1024 C C   . PHE A 1 269 ? 109.743 147.483 145.094 1.00 73.35  ?  153 PHE E C   1 
ATOM   1025 O O   . PHE A 1 269 ? 109.216 147.944 144.077 1.00 79.63  ?  153 PHE E O   1 
ATOM   1026 C CB  . PHE A 1 269 ? 111.857 148.788 144.739 1.00 68.80  ?  153 PHE E CB  1 
ATOM   1027 C CG  . PHE A 1 269 ? 112.846 149.769 145.298 1.00 70.42  ?  153 PHE E CG  1 
ATOM   1028 C CD1 . PHE A 1 269 ? 112.486 150.629 146.322 1.00 71.32  ?  153 PHE E CD1 1 
ATOM   1029 C CD2 . PHE A 1 269 ? 114.131 149.839 144.794 1.00 69.77  ?  153 PHE E CD2 1 
ATOM   1030 C CE1 . PHE A 1 269 ? 113.393 151.535 146.835 1.00 70.65  ?  153 PHE E CE1 1 
ATOM   1031 C CE2 . PHE A 1 269 ? 115.039 150.745 145.301 1.00 69.96  ?  153 PHE E CE2 1 
ATOM   1032 C CZ  . PHE A 1 269 ? 114.671 151.592 146.323 1.00 71.37  ?  153 PHE E CZ  1 
ATOM   1033 N N   . SER A 1 270 ? 109.352 146.330 145.628 1.00 80.30  ?  154 SER E N   1 
ATOM   1034 C CA  . SER A 1 270 ? 108.171 145.616 145.168 1.00 83.07  ?  154 SER E CA  1 
ATOM   1035 C C   . SER A 1 270 ? 106.927 145.998 145.955 1.00 82.84  ?  154 SER E C   1 
ATOM   1036 O O   . SER A 1 270 ? 105.859 145.422 145.724 1.00 83.13  ?  154 SER E O   1 
ATOM   1037 C CB  . SER A 1 270 ? 108.396 144.104 145.254 1.00 78.85  ?  154 SER E CB  1 
ATOM   1038 N N   . MET A 1 271 ? 107.045 146.951 146.877 1.00 82.32  ?  155 MET E N   1 
ATOM   1039 C CA  . MET A 1 271 ? 105.940 147.407 147.716 1.00 85.82  ?  155 MET E CA  1 
ATOM   1040 C C   . MET A 1 271 ? 105.380 148.739 147.238 1.00 89.75  ?  155 MET E C   1 
ATOM   1041 O O   . MET A 1 271 ? 105.046 149.608 148.048 1.00 91.45  ?  155 MET E O   1 
ATOM   1042 C CB  . MET A 1 271 ? 106.383 147.504 149.173 1.00 86.13  ?  155 MET E CB  1 
ATOM   1043 C CG  . MET A 1 271 ? 106.636 146.164 149.852 1.00 88.43  ?  155 MET E CG  1 
ATOM   1044 S SD  . MET A 1 271 ? 107.849 145.125 149.016 1.00 83.08  ?  155 MET E SD  1 
ATOM   1045 C CE  . MET A 1 271 ? 109.370 145.905 149.543 1.00 84.51  ?  155 MET E CE  1 
ATOM   1046 N N   . LEU A 1 272 ? 105.281 148.933 145.921 1.00 85.76  ?  156 LEU E N   1 
ATOM   1047 C CA  . LEU A 1 272 ? 104.710 150.169 145.397 1.00 86.41  ?  156 LEU E CA  1 
ATOM   1048 C C   . LEU A 1 272 ? 103.220 150.255 145.704 1.00 91.39  ?  156 LEU E C   1 
ATOM   1049 O O   . LEU A 1 272 ? 102.776 151.129 146.458 1.00 89.44  ?  156 LEU E O   1 
ATOM   1050 C CB  . LEU A 1 272 ? 104.955 150.260 143.890 1.00 85.20  ?  156 LEU E CB  1 
ATOM   1051 N N   . GLU A 1 273 ? 102.431 149.340 145.141 1.00 94.98  ?  157 GLU E N   1 
ATOM   1052 C CA  . GLU A 1 273 ? 100.993 149.307 145.369 1.00 92.78  ?  157 GLU E CA  1 
ATOM   1053 C C   . GLU A 1 273 ? 100.624 148.734 146.731 1.00 92.31  ?  157 GLU E C   1 
ATOM   1054 O O   . GLU A 1 273 ? 99.579  149.101 147.278 1.00 93.97  ?  157 GLU E O   1 
ATOM   1055 C CB  . GLU A 1 273 ? 100.303 148.497 144.261 1.00 91.35  ?  157 GLU E CB  1 
ATOM   1056 C CG  . GLU A 1 273 ? 98.814  148.241 144.470 1.00 89.77  ?  157 GLU E CG  1 
ATOM   1057 C CD  . GLU A 1 273 ? 97.981  149.510 144.424 1.00 88.83  ?  157 GLU E CD  1 
ATOM   1058 O OE1 . GLU A 1 273 ? 97.841  150.177 145.470 1.00 84.99  ?  157 GLU E OE1 1 
ATOM   1059 O OE2 . GLU A 1 273 ? 97.459  149.839 143.338 1.00 91.81  -1 157 GLU E OE2 1 
ATOM   1060 N N   . TRP A 1 274 ? 101.473 147.886 147.310 1.00 88.39  ?  158 TRP E N   1 
ATOM   1061 C CA  . TRP A 1 274 ? 101.133 147.171 148.539 1.00 85.62  ?  158 TRP E CA  1 
ATOM   1062 C C   . TRP A 1 274 ? 101.152 148.099 149.753 1.00 85.47  ?  158 TRP E C   1 
ATOM   1063 O O   . TRP A 1 274 ? 102.031 148.048 150.611 1.00 88.06  ?  158 TRP E O   1 
ATOM   1064 C CB  . TRP A 1 274 ? 102.065 145.986 148.734 1.00 85.12  ?  158 TRP E CB  1 
ATOM   1065 C CG  . TRP A 1 274 ? 101.793 144.890 147.772 1.00 87.50  ?  158 TRP E CG  1 
ATOM   1066 C CD1 . TRP A 1 274 ? 102.641 144.395 146.831 1.00 82.59  ?  158 TRP E CD1 1 
ATOM   1067 C CD2 . TRP A 1 274 ? 100.576 144.142 147.656 1.00 89.59  ?  158 TRP E CD2 1 
ATOM   1068 N NE1 . TRP A 1 274 ? 102.027 143.385 146.134 1.00 84.86  ?  158 TRP E NE1 1 
ATOM   1069 C CE2 . TRP A 1 274 ? 100.759 143.210 146.621 1.00 86.13  ?  158 TRP E CE2 1 
ATOM   1070 C CE3 . TRP A 1 274 ? 99.350  144.171 148.328 1.00 87.80  ?  158 TRP E CE3 1 
ATOM   1071 C CZ2 . TRP A 1 274 ? 99.763  142.313 146.241 1.00 84.56  ?  158 TRP E CZ2 1 
ATOM   1072 C CZ3 . TRP A 1 274 ? 98.363  143.282 147.948 1.00 86.34  ?  158 TRP E CZ3 1 
ATOM   1073 C CH2 . TRP A 1 274 ? 98.575  142.366 146.914 1.00 85.77  ?  158 TRP E CH2 1 
ATOM   1074 N N   . ARG A 1 275 ? 100.141 148.960 149.807 1.00 99.62  ?  159 ARG E N   1 
ATOM   1075 C CA  . ARG A 1 275 ? 99.816  149.693 151.027 1.00 102.47 ?  159 ARG E CA  1 
ATOM   1076 C C   . ARG A 1 275 ? 98.863  148.881 151.897 1.00 103.58 ?  159 ARG E C   1 
ATOM   1077 O O   . ARG A 1 275 ? 97.822  149.359 152.345 1.00 102.56 ?  159 ARG E O   1 
ATOM   1078 C CB  . ARG A 1 275 ? 99.224  151.053 150.678 1.00 99.89  ?  159 ARG E CB  1 
ATOM   1079 N N   . PHE A 1 276 ? 99.231  147.625 152.135 1.00 104.43 ?  160 PHE E N   1 
ATOM   1080 C CA  . PHE A 1 276 ? 98.430  146.681 152.902 1.00 103.35 ?  160 PHE E CA  1 
ATOM   1081 C C   . PHE A 1 276 ? 99.218  146.243 154.128 1.00 103.51 ?  160 PHE E C   1 
ATOM   1082 O O   . PHE A 1 276 ? 100.207 145.515 154.000 1.00 100.59 ?  160 PHE E O   1 
ATOM   1083 C CB  . PHE A 1 276 ? 98.054  145.460 152.057 1.00 103.24 ?  160 PHE E CB  1 
ATOM   1084 C CG  . PHE A 1 276 ? 96.879  145.680 151.139 1.00 104.27 ?  160 PHE E CG  1 
ATOM   1085 C CD1 . PHE A 1 276 ? 96.478  146.958 150.784 1.00 104.52 ?  160 PHE E CD1 1 
ATOM   1086 C CD2 . PHE A 1 276 ? 96.177  144.601 150.627 1.00 103.51 ?  160 PHE E CD2 1 
ATOM   1087 C CE1 . PHE A 1 276 ? 95.400  147.155 149.940 1.00 102.75 ?  160 PHE E CE1 1 
ATOM   1088 C CE2 . PHE A 1 276 ? 95.099  144.793 149.783 1.00 104.73 ?  160 PHE E CE2 1 
ATOM   1089 C CZ  . PHE A 1 276 ? 94.710  146.071 149.439 1.00 102.90 ?  160 PHE E CZ  1 
ATOM   1090 N N   . CYS A 1 277 ? 98.782  146.701 155.304 1.00 113.57 ?  161 CYS E N   1 
ATOM   1091 C CA  . CYS A 1 277 ? 99.394  146.346 156.591 1.00 115.38 ?  161 CYS E CA  1 
ATOM   1092 C C   . CYS A 1 277 ? 100.909 146.564 156.589 1.00 116.41 ?  161 CYS E C   1 
ATOM   1093 O O   . CYS A 1 277 ? 101.658 145.851 157.262 1.00 116.24 ?  161 CYS E O   1 
ATOM   1094 C CB  . CYS A 1 277 ? 99.036  144.908 156.997 1.00 113.19 ?  161 CYS E CB  1 
ATOM   1095 S SG  . CYS A 1 277 ? 100.000 143.561 156.253 1.00 112.65 ?  161 CYS E SG  1 
ATOM   1096 N N   . ASP A 1 278 ? 101.369 147.573 155.846 1.00 111.68 ?  162 ASP E N   1 
ATOM   1097 C CA  . ASP A 1 278 ? 102.797 147.873 155.802 1.00 109.31 ?  162 ASP E CA  1 
ATOM   1098 C C   . ASP A 1 278 ? 103.306 148.340 157.161 1.00 112.15 ?  162 ASP E C   1 
ATOM   1099 O O   . ASP A 1 278 ? 104.405 147.967 157.587 1.00 112.28 ?  162 ASP E O   1 
ATOM   1100 C CB  . ASP A 1 278 ? 103.082 148.920 154.726 1.00 107.10 ?  162 ASP E CB  1 
ATOM   1101 C CG  . ASP A 1 278 ? 103.771 148.333 153.512 1.00 109.54 ?  162 ASP E CG  1 
ATOM   1102 O OD1 . ASP A 1 278 ? 103.965 147.100 153.475 1.00 108.44 ?  162 ASP E OD1 1 
ATOM   1103 O OD2 . ASP A 1 278 ? 104.122 149.103 152.595 1.00 111.82 -1 162 ASP E OD2 1 
ATOM   1104 N N   . PHE A 1 279 ? 102.522 149.161 157.856 1.00 113.84 ?  163 PHE E N   1 
ATOM   1105 C CA  . PHE A 1 279 ? 102.885 149.662 159.177 1.00 111.82 ?  163 PHE E CA  1 
ATOM   1106 C C   . PHE A 1 279 ? 102.583 148.573 160.199 1.00 110.22 ?  163 PHE E C   1 
ATOM   1107 O O   . PHE A 1 279 ? 101.423 148.361 160.568 1.00 109.10 ?  163 PHE E O   1 
ATOM   1108 C CB  . PHE A 1 279 ? 102.128 150.946 159.506 1.00 110.60 ?  163 PHE E CB  1 
ATOM   1109 N N   . LEU A 1 280 ? 103.627 147.887 160.654 1.00 109.80 ?  164 LEU E N   1 
ATOM   1110 C CA  . LEU A 1 280 ? 103.506 146.797 161.615 1.00 111.97 ?  164 LEU E CA  1 
ATOM   1111 C C   . LEU A 1 280 ? 104.073 147.196 162.974 1.00 112.91 ?  164 LEU E C   1 
ATOM   1112 O O   . LEU A 1 280 ? 104.378 146.347 163.814 1.00 112.66 ?  164 LEU E O   1 
ATOM   1113 C CB  . LEU A 1 280 ? 104.199 145.541 161.091 1.00 111.30 ?  164 LEU E CB  1 
ATOM   1114 C CG  . LEU A 1 280 ? 103.489 144.786 159.965 1.00 111.19 ?  164 LEU E CG  1 
ATOM   1115 C CD1 . LEU A 1 280 ? 104.498 144.123 159.042 1.00 107.57 ?  164 LEU E CD1 1 
ATOM   1116 C CD2 . LEU A 1 280 ? 102.523 143.759 160.534 1.00 111.79 ?  164 LEU E CD2 1 
ATOM   1117 N N   . PHE A 1 281 ? 104.218 148.497 163.202 1.00 114.00 ?  165 PHE E N   1 
ATOM   1118 C CA  . PHE A 1 281 ? 104.778 148.999 164.450 1.00 112.77 ?  165 PHE E CA  1 
ATOM   1119 C C   . PHE A 1 281 ? 103.809 149.954 165.140 1.00 112.19 ?  165 PHE E C   1 
ATOM   1120 O O   . PHE A 1 281 ? 103.899 151.171 164.974 1.00 112.17 ?  165 PHE E O   1 
ATOM   1121 C CB  . PHE A 1 281 ? 106.115 149.698 164.194 1.00 113.73 ?  165 PHE E CB  1 
ATOM   1122 C CG  . PHE A 1 281 ? 106.944 149.049 163.121 1.00 116.09 ?  165 PHE E CG  1 
ATOM   1123 C CD1 . PHE A 1 281 ? 107.356 147.731 163.245 1.00 114.56 ?  165 PHE E CD1 1 
ATOM   1124 C CD2 . PHE A 1 281 ? 107.310 149.755 161.986 1.00 115.20 ?  165 PHE E CD2 1 
ATOM   1125 C CE1 . PHE A 1 281 ? 108.117 147.132 162.259 1.00 113.28 ?  165 PHE E CE1 1 
ATOM   1126 C CE2 . PHE A 1 281 ? 108.071 149.160 160.996 1.00 112.06 ?  165 PHE E CE2 1 
ATOM   1127 C CZ  . PHE A 1 281 ? 108.474 147.847 161.133 1.00 112.15 ?  165 PHE E CZ  1 
ATOM   1128 N N   . SER A 1 286 ? 106.501 153.447 161.037 1.00 102.21 ?  170 SER E N   1 
ATOM   1129 C CA  . SER A 1 286 ? 105.460 154.444 161.260 1.00 104.24 ?  170 SER E CA  1 
ATOM   1130 C C   . SER A 1 286 ? 105.559 155.578 160.243 1.00 105.67 ?  170 SER E C   1 
ATOM   1131 O O   . SER A 1 286 ? 104.551 156.017 159.692 1.00 106.23 ?  170 SER E O   1 
ATOM   1132 C CB  . SER A 1 286 ? 105.545 154.999 162.683 1.00 103.81 ?  170 SER E CB  1 
ATOM   1133 O OG  . SER A 1 286 ? 104.617 156.051 162.878 1.00 101.58 ?  170 SER E OG  1 
ATOM   1134 N N   . SER A 1 287 ? 106.782 156.049 159.997 1.00 112.17 ?  171 SER E N   1 
ATOM   1135 C CA  . SER A 1 287 ? 107.022 157.103 159.010 1.00 111.68 ?  171 SER E CA  1 
ATOM   1136 C C   . SER A 1 287 ? 107.129 156.472 157.621 1.00 112.73 ?  171 SER E C   1 
ATOM   1137 O O   . SER A 1 287 ? 108.202 156.337 157.031 1.00 111.80 ?  171 SER E O   1 
ATOM   1138 C CB  . SER A 1 287 ? 108.268 157.900 159.370 1.00 111.44 ?  171 SER E CB  1 
ATOM   1139 O OG  . SER A 1 287 ? 108.492 158.942 158.436 1.00 112.18 ?  171 SER E OG  1 
ATOM   1140 N N   . TRP A 1 288 ? 105.968 156.077 157.108 1.00 116.51 ?  172 TRP E N   1 
ATOM   1141 C CA  . TRP A 1 288 ? 105.851 155.356 155.851 1.00 114.43 ?  172 TRP E CA  1 
ATOM   1142 C C   . TRP A 1 288 ? 104.774 156.010 154.995 1.00 114.43 ?  172 TRP E C   1 
ATOM   1143 O O   . TRP A 1 288 ? 103.680 156.322 155.476 1.00 113.35 ?  172 TRP E O   1 
ATOM   1144 C CB  . TRP A 1 288 ? 105.554 153.867 156.131 1.00 114.12 ?  172 TRP E CB  1 
ATOM   1145 C CG  . TRP A 1 288 ? 104.104 153.475 156.162 1.00 116.50 ?  172 TRP E CG  1 
ATOM   1146 C CD1 . TRP A 1 288 ? 103.323 153.339 157.271 1.00 116.03 ?  172 TRP E CD1 1 
ATOM   1147 C CD2 . TRP A 1 288 ? 103.301 153.043 155.056 1.00 116.32 ?  172 TRP E CD2 1 
ATOM   1148 N NE1 . TRP A 1 288 ? 102.062 152.924 156.919 1.00 115.64 ?  172 TRP E NE1 1 
ATOM   1149 C CE2 . TRP A 1 288 ? 102.025 152.725 155.565 1.00 115.70 ?  172 TRP E CE2 1 
ATOM   1150 C CE3 . TRP A 1 288 ? 103.526 152.921 153.682 1.00 116.38 ?  172 TRP E CE3 1 
ATOM   1151 C CZ2 . TRP A 1 288 ? 100.981 152.294 154.750 1.00 114.70 ?  172 TRP E CZ2 1 
ATOM   1152 C CZ3 . TRP A 1 288 ? 102.485 152.492 152.874 1.00 114.49 ?  172 TRP E CZ3 1 
ATOM   1153 C CH2 . TRP A 1 288 ? 101.231 152.186 153.411 1.00 113.61 ?  172 TRP E CH2 1 
ATOM   1154 N N   . CYS A 1 289 ? 105.103 156.240 153.725 1.00 111.99 ?  173 CYS E N   1 
ATOM   1155 C CA  . CYS A 1 289 ? 104.243 157.004 152.825 1.00 113.24 ?  173 CYS E CA  1 
ATOM   1156 C C   . CYS A 1 289 ? 102.957 156.226 152.576 1.00 111.41 ?  173 CYS E C   1 
ATOM   1157 O O   . CYS A 1 289 ? 102.949 155.258 151.809 1.00 111.39 ?  173 CYS E O   1 
ATOM   1158 C CB  . CYS A 1 289 ? 104.969 157.302 151.516 1.00 112.48 ?  173 CYS E CB  1 
ATOM   1159 S SG  . CYS A 1 289 ? 106.551 158.155 151.718 1.00 115.49 ?  173 CYS E SG  1 
ATOM   1160 N N   . GLU A 1 290 ? 101.865 156.672 153.204 1.00 104.97 ?  174 GLU E N   1 
ATOM   1161 C CA  . GLU A 1 290 ? 100.608 155.933 153.207 1.00 106.22 ?  174 GLU E CA  1 
ATOM   1162 C C   . GLU A 1 290 ? 100.127 155.580 151.802 1.00 107.62 ?  174 GLU E C   1 
ATOM   1163 O O   . GLU A 1 290 ? 99.951  154.402 151.473 1.00 107.25 ?  174 GLU E O   1 
ATOM   1164 C CB  . GLU A 1 290 ? 99.540  156.743 153.950 1.00 105.95 ?  174 GLU E CB  1 
ATOM   1165 C CG  . GLU A 1 290 ? 99.648  156.676 155.467 1.00 106.97 ?  174 GLU E CG  1 
ATOM   1166 C CD  . GLU A 1 290 ? 100.844 157.438 156.008 1.00 107.60 ?  174 GLU E CD  1 
ATOM   1167 O OE1 . GLU A 1 290 ? 101.295 158.391 155.340 1.00 107.76 ?  174 GLU E OE1 1 
ATOM   1168 O OE2 . GLU A 1 290 ? 101.335 157.079 157.099 1.00 105.18 -1 174 GLU E OE2 1 
ATOM   1169 N N   . THR A 1 291 ? 99.915  156.587 150.956 1.00 101.77 ?  175 THR E N   1 
ATOM   1170 C CA  . THR A 1 291 ? 99.386  156.330 149.621 1.00 98.94  ?  175 THR E CA  1 
ATOM   1171 C C   . THR A 1 291 ? 100.356 156.785 148.537 1.00 98.48  ?  175 THR E C   1 
ATOM   1172 O O   . THR A 1 291 ? 100.574 156.070 147.553 1.00 94.61  ?  175 THR E O   1 
ATOM   1173 C CB  . THR A 1 291 ? 98.032  157.024 149.439 1.00 99.14  ?  175 THR E CB  1 
ATOM   1174 O OG1 . THR A 1 291 ? 97.091  156.499 150.384 1.00 99.20  ?  175 THR E OG1 1 
ATOM   1175 C CG2 . THR A 1 291 ? 97.501  156.807 148.031 1.00 99.97  ?  175 THR E CG2 1 
ATOM   1176 N N   . SER A 1 292 ? 100.954 157.962 148.715 1.00 101.40 ?  176 SER E N   1 
ATOM   1177 C CA  . SER A 1 292 ? 101.842 158.538 147.706 1.00 101.03 ?  176 SER E CA  1 
ATOM   1178 C C   . SER A 1 292 ? 103.272 158.083 147.986 1.00 99.99  ?  176 SER E C   1 
ATOM   1179 O O   . SER A 1 292 ? 104.168 158.872 148.299 1.00 99.33  ?  176 SER E O   1 
ATOM   1180 C CB  . SER A 1 292 ? 101.723 160.056 147.689 1.00 98.72  ?  176 SER E CB  1 
ATOM   1181 O OG  . SER A 1 292 ? 101.538 160.572 148.993 1.00 95.74  ?  176 SER E OG  1 
ATOM   1182 N N   . ASP A 1 293 ? 103.484 156.776 147.866 1.00 92.36  ?  177 ASP E N   1 
ATOM   1183 C CA  . ASP A 1 293 ? 104.799 156.158 148.007 1.00 90.58  ?  177 ASP E CA  1 
ATOM   1184 C C   . ASP A 1 293 ? 105.402 156.024 146.612 1.00 92.85  ?  177 ASP E C   1 
ATOM   1185 O O   . ASP A 1 293 ? 105.100 155.074 145.883 1.00 94.34  ?  177 ASP E O   1 
ATOM   1186 C CB  . ASP A 1 293 ? 104.693 154.806 148.705 1.00 89.12  ?  177 ASP E CB  1 
ATOM   1187 C CG  . ASP A 1 293 ? 106.031 154.293 149.183 1.00 90.72  ?  177 ASP E CG  1 
ATOM   1188 O OD1 . ASP A 1 293 ? 106.837 153.856 148.334 1.00 89.78  ?  177 ASP E OD1 1 
ATOM   1189 O OD2 . ASP A 1 293 ? 106.278 154.324 150.406 1.00 91.76  -1 177 ASP E OD2 1 
ATOM   1190 N N   . PHE A 1 294 ? 106.260 156.975 146.247 1.00 84.93  ?  178 PHE E N   1 
ATOM   1191 C CA  . PHE A 1 294 ? 106.839 157.006 144.910 1.00 79.32  ?  178 PHE E CA  1 
ATOM   1192 C C   . PHE A 1 294 ? 108.329 156.692 144.940 1.00 78.83  ?  178 PHE E C   1 
ATOM   1193 O O   . PHE A 1 294 ? 109.096 157.226 144.133 1.00 78.34  ?  178 PHE E O   1 
ATOM   1194 C CB  . PHE A 1 294 ? 106.601 158.370 144.259 1.00 77.09  ?  178 PHE E CB  1 
ATOM   1195 N N   . ILE A 1 295 ? 108.749 155.834 145.864 1.00 79.89  ?  179 ILE E N   1 
ATOM   1196 C CA  . ILE A 1 295 ? 110.150 155.423 145.953 1.00 83.66  ?  179 ILE E CA  1 
ATOM   1197 C C   . ILE A 1 295 ? 110.451 154.352 144.906 1.00 84.60  ?  179 ILE E C   1 
ATOM   1198 O O   . ILE A 1 295 ? 111.498 154.434 144.245 1.00 83.19  ?  179 ILE E O   1 
ATOM   1199 C CB  . ILE A 1 295 ? 110.507 154.951 147.373 1.00 81.41  ?  179 ILE E CB  1 
ATOM   1200 C CG1 . ILE A 1 295 ? 109.915 155.901 148.417 1.00 77.11  ?  179 ILE E CG1 1 
ATOM   1201 C CG2 . ILE A 1 295 ? 112.016 154.849 147.537 1.00 82.31  ?  179 ILE E CG2 1 
ATOM   1202 C CD1 . ILE A 1 295 ? 110.427 157.322 148.315 1.00 76.46  ?  179 ILE E CD1 1 
ATOM   1203 N N   . PRO A 1 296 ? 109.608 153.324 144.720 1.00 77.56  ?  180 PRO E N   1 
ATOM   1204 C CA  . PRO A 1 296 ? 109.825 152.429 143.568 1.00 73.39  ?  180 PRO E CA  1 
ATOM   1205 C C   . PRO A 1 296 ? 109.751 153.143 142.230 1.00 74.26  ?  180 PRO E C   1 
ATOM   1206 O O   . PRO A 1 296 ? 110.475 152.771 141.298 1.00 76.93  ?  180 PRO E O   1 
ATOM   1207 C CB  . PRO A 1 296 ? 108.716 151.376 143.698 1.00 77.14  ?  180 PRO E CB  1 
ATOM   1208 C CG  . PRO A 1 296 ? 108.001 151.653 144.945 1.00 78.93  ?  180 PRO E CG  1 
ATOM   1209 C CD  . PRO A 1 296 ? 108.605 152.793 145.661 1.00 71.83  ?  180 PRO E CD  1 
ATOM   1210 N N   . VAL A 1 297 ? 108.895 154.159 142.104 1.00 62.43  ?  181 VAL E N   1 
ATOM   1211 C CA  . VAL A 1 297 ? 108.878 154.962 140.885 1.00 58.07  ?  181 VAL E CA  1 
ATOM   1212 C C   . VAL A 1 297 ? 110.204 155.687 140.714 1.00 59.03  ?  181 VAL E C   1 
ATOM   1213 O O   . VAL A 1 297 ? 110.725 155.807 139.599 1.00 66.83  ?  181 VAL E O   1 
ATOM   1214 C CB  . VAL A 1 297 ? 107.696 155.947 140.901 1.00 64.04  ?  181 VAL E CB  1 
ATOM   1215 C CG1 . VAL A 1 297 ? 107.493 156.546 139.518 1.00 60.64  ?  181 VAL E CG1 1 
ATOM   1216 C CG2 . VAL A 1 297 ? 106.438 155.248 141.362 1.00 68.00  ?  181 VAL E CG2 1 
ATOM   1217 N N   . ALA A 1 298 ? 110.762 156.196 141.814 1.00 57.68  ?  182 ALA E N   1 
ATOM   1218 C CA  . ALA A 1 298 ? 112.074 156.828 141.749 1.00 59.96  ?  182 ALA E CA  1 
ATOM   1219 C C   . ALA A 1 298 ? 113.137 155.836 141.300 1.00 60.98  ?  182 ALA E C   1 
ATOM   1220 O O   . ALA A 1 298 ? 114.004 156.173 140.489 1.00 67.59  ?  182 ALA E O   1 
ATOM   1221 C CB  . ALA A 1 298 ? 112.437 157.428 143.106 1.00 62.83  ?  182 ALA E CB  1 
ATOM   1222 N N   . TRP A 1 299 ? 113.081 154.604 141.809 1.00 54.93  ?  183 TRP E N   1 
ATOM   1223 C CA  . TRP A 1 299 ? 114.037 153.582 141.389 1.00 50.73  ?  183 TRP E CA  1 
ATOM   1224 C C   . TRP A 1 299 ? 113.902 153.270 139.904 1.00 51.04  ?  183 TRP E C   1 
ATOM   1225 O O   . TRP A 1 299 ? 114.906 153.145 139.193 1.00 56.22  ?  183 TRP E O   1 
ATOM   1226 C CB  . TRP A 1 299 ? 113.837 152.315 142.220 1.00 58.82  ?  183 TRP E CB  1 
ATOM   1227 C CG  . TRP A 1 299 ? 114.707 151.167 141.813 1.00 57.63  ?  183 TRP E CG  1 
ATOM   1228 C CD1 . TRP A 1 299 ? 114.302 149.998 141.239 1.00 57.59  ?  183 TRP E CD1 1 
ATOM   1229 C CD2 . TRP A 1 299 ? 116.126 151.066 141.971 1.00 54.96  ?  183 TRP E CD2 1 
ATOM   1230 N NE1 . TRP A 1 299 ? 115.382 149.179 141.020 1.00 56.70  ?  183 TRP E NE1 1 
ATOM   1231 C CE2 . TRP A 1 299 ? 116.514 149.812 141.461 1.00 55.96  ?  183 TRP E CE2 1 
ATOM   1232 C CE3 . TRP A 1 299 ? 117.107 151.916 142.489 1.00 56.05  ?  183 TRP E CE3 1 
ATOM   1233 C CZ2 . TRP A 1 299 ? 117.840 149.388 141.454 1.00 54.31  ?  183 TRP E CZ2 1 
ATOM   1234 C CZ3 . TRP A 1 299 ? 118.422 151.493 142.481 1.00 59.19  ?  183 TRP E CZ3 1 
ATOM   1235 C CH2 . TRP A 1 299 ? 118.776 150.241 141.967 1.00 57.14  ?  183 TRP E CH2 1 
ATOM   1236 N N   . LEU A 1 300 ? 112.667 153.140 139.418 1.00 51.03  ?  184 LEU E N   1 
ATOM   1237 C CA  . LEU A 1 300 ? 112.455 152.841 138.005 1.00 47.20  ?  184 LEU E CA  1 
ATOM   1238 C C   . LEU A 1 300 ? 112.939 153.980 137.117 1.00 48.43  ?  184 LEU E C   1 
ATOM   1239 O O   . LEU A 1 300 ? 113.590 153.743 136.089 1.00 58.29  ?  184 LEU E O   1 
ATOM   1240 C CB  . LEU A 1 300 ? 110.977 152.554 137.750 1.00 50.03  ?  184 LEU E CB  1 
ATOM   1241 C CG  . LEU A 1 300 ? 110.490 152.693 136.308 1.00 56.99  ?  184 LEU E CG  1 
ATOM   1242 C CD1 . LEU A 1 300 ? 111.083 151.601 135.432 1.00 54.35  ?  184 LEU E CD1 1 
ATOM   1243 C CD2 . LEU A 1 300 ? 108.972 152.664 136.258 1.00 59.09  ?  184 LEU E CD2 1 
ATOM   1244 N N   . ILE A 1 301 ? 112.632 155.224 137.492 1.00 39.51  ?  185 ILE E N   1 
ATOM   1245 C CA  . ILE A 1 301 ? 113.076 156.353 136.687 1.00 38.40  ?  185 ILE E CA  1 
ATOM   1246 C C   . ILE A 1 301 ? 114.590 156.491 136.752 1.00 43.60  ?  185 ILE E C   1 
ATOM   1247 O O   . ILE A 1 301 ? 115.223 156.887 135.767 1.00 47.63  ?  185 ILE E O   1 
ATOM   1248 C CB  . ILE A 1 301 ? 112.347 157.645 137.111 1.00 40.67  ?  185 ILE E CB  1 
ATOM   1249 C CG1 . ILE A 1 301 ? 112.252 158.608 135.927 1.00 49.35  ?  185 ILE E CG1 1 
ATOM   1250 C CG2 . ILE A 1 301 ? 113.031 158.318 138.290 1.00 42.62  ?  185 ILE E CG2 1 
ATOM   1251 C CD1 . ILE A 1 301 ? 111.416 158.084 134.780 1.00 48.62  ?  185 ILE E CD1 1 
ATOM   1252 N N   . PHE A 1 302 ? 115.202 156.145 137.888 1.00 46.65  ?  186 PHE E N   1 
ATOM   1253 C CA  . PHE A 1 302 ? 116.656 156.147 137.973 1.00 44.60  ?  186 PHE E CA  1 
ATOM   1254 C C   . PHE A 1 302 ? 117.256 155.109 137.039 1.00 43.75  ?  186 PHE E C   1 
ATOM   1255 O O   . PHE A 1 302 ? 118.252 155.378 136.362 1.00 54.12  ?  186 PHE E O   1 
ATOM   1256 C CB  . PHE A 1 302 ? 117.103 155.892 139.411 1.00 43.40  ?  186 PHE E CB  1 
ATOM   1257 C CG  . PHE A 1 302 ? 118.447 155.236 139.518 1.00 45.66  ?  186 PHE E CG  1 
ATOM   1258 C CD1 . PHE A 1 302 ? 119.606 155.978 139.370 1.00 54.23  ?  186 PHE E CD1 1 
ATOM   1259 C CD2 . PHE A 1 302 ? 118.554 153.879 139.766 1.00 48.72  ?  186 PHE E CD2 1 
ATOM   1260 C CE1 . PHE A 1 302 ? 120.846 155.379 139.467 1.00 57.30  ?  186 PHE E CE1 1 
ATOM   1261 C CE2 . PHE A 1 302 ? 119.791 153.273 139.862 1.00 54.17  ?  186 PHE E CE2 1 
ATOM   1262 C CZ  . PHE A 1 302 ? 120.939 154.024 139.714 1.00 55.74  ?  186 PHE E CZ  1 
ATOM   1263 N N   . LEU A 1 303 ? 116.665 153.914 136.993 1.00 37.80  ?  187 LEU E N   1 
ATOM   1264 C CA  . LEU A 1 303 ? 117.151 152.882 136.081 1.00 32.94  ?  187 LEU E CA  1 
ATOM   1265 C C   . LEU A 1 303 ? 117.051 153.344 134.633 1.00 35.35  ?  187 LEU E C   1 
ATOM   1266 O O   . LEU A 1 303 ? 118.004 153.211 133.854 1.00 42.08  ?  187 LEU E O   1 
ATOM   1267 C CB  . LEU A 1 303 ? 116.360 151.592 136.287 1.00 42.58  ?  187 LEU E CB  1 
ATOM   1268 C CG  . LEU A 1 303 ? 116.805 150.677 137.427 1.00 48.87  ?  187 LEU E CG  1 
ATOM   1269 C CD1 . LEU A 1 303 ? 116.033 149.371 137.381 1.00 42.85  ?  187 LEU E CD1 1 
ATOM   1270 C CD2 . LEU A 1 303 ? 118.300 150.422 137.356 1.00 45.47  ?  187 LEU E CD2 1 
ATOM   1271 N N   . CYS A 1 304 ? 115.902 153.909 134.260 1.00 31.16  ?  188 CYS E N   1 
ATOM   1272 C CA  . CYS A 1 304 ? 115.717 154.364 132.886 1.00 38.92  ?  188 CYS E CA  1 
ATOM   1273 C C   . CYS A 1 304 ? 116.706 155.469 132.534 1.00 44.08  ?  188 CYS E C   1 
ATOM   1274 O O   . CYS A 1 304 ? 117.339 155.440 131.469 1.00 48.27  ?  188 CYS E O   1 
ATOM   1275 C CB  . CYS A 1 304 ? 114.281 154.840 132.681 1.00 45.78  ?  188 CYS E CB  1 
ATOM   1276 S SG  . CYS A 1 304 ? 114.004 155.698 131.116 1.00 62.24  ?  188 CYS E SG  1 
ATOM   1277 N N   . VAL A 1 305 ? 116.870 156.448 133.427 1.00 40.18  ?  189 VAL E N   1 
ATOM   1278 C CA  . VAL A 1 305 ? 117.734 157.580 133.122 1.00 38.01  ?  189 VAL E CA  1 
ATOM   1279 C C   . VAL A 1 305 ? 119.196 157.155 133.105 1.00 37.43  ?  189 VAL E C   1 
ATOM   1280 O O   . VAL A 1 305 ? 119.986 157.664 132.303 1.00 38.41  ?  189 VAL E O   1 
ATOM   1281 C CB  . VAL A 1 305 ? 117.477 158.743 134.101 1.00 43.70  ?  189 VAL E CB  1 
ATOM   1282 C CG1 . VAL A 1 305 ? 118.060 158.457 135.474 1.00 44.39  ?  189 VAL E CG1 1 
ATOM   1283 C CG2 . VAL A 1 305 ? 118.040 160.038 133.538 1.00 49.69  ?  189 VAL E CG2 1 
ATOM   1284 N N   . VAL A 1 306 ? 119.587 156.215 133.969 1.00 37.26  ?  190 VAL E N   1 
ATOM   1285 C CA  . VAL A 1 306 ? 120.978 155.776 133.975 1.00 34.11  ?  190 VAL E CA  1 
ATOM   1286 C C   . VAL A 1 306 ? 121.282 154.957 132.728 1.00 34.38  ?  190 VAL E C   1 
ATOM   1287 O O   . VAL A 1 306 ? 122.368 155.073 132.151 1.00 50.58  ?  190 VAL E O   1 
ATOM   1288 C CB  . VAL A 1 306 ? 121.315 155.020 135.276 1.00 39.66  ?  190 VAL E CB  1 
ATOM   1289 C CG1 . VAL A 1 306 ? 120.731 153.625 135.287 1.00 48.11  ?  190 VAL E CG1 1 
ATOM   1290 C CG2 . VAL A 1 306 ? 122.822 154.969 135.479 1.00 43.40  ?  190 VAL E CG2 1 
ATOM   1291 N N   . LEU A 1 307 ? 120.327 154.143 132.265 1.00 26.55  ?  191 LEU E N   1 
ATOM   1292 C CA  . LEU A 1 307 ? 120.529 153.446 130.999 1.00 35.35  ?  191 LEU E CA  1 
ATOM   1293 C C   . LEU A 1 307 ? 120.658 154.429 129.842 1.00 38.17  ?  191 LEU E C   1 
ATOM   1294 O O   . LEU A 1 307 ? 121.555 154.292 128.996 1.00 48.76  ?  191 LEU E O   1 
ATOM   1295 C CB  . LEU A 1 307 ? 119.383 152.466 130.750 1.00 40.45  ?  191 LEU E CB  1 
ATOM   1296 C CG  . LEU A 1 307 ? 119.262 151.868 129.348 1.00 32.83  ?  191 LEU E CG  1 
ATOM   1297 C CD1 . LEU A 1 307 ? 118.910 150.402 129.444 1.00 41.82  ?  191 LEU E CD1 1 
ATOM   1298 C CD2 . LEU A 1 307 ? 118.204 152.600 128.540 1.00 35.79  ?  191 LEU E CD2 1 
ATOM   1299 N N   . CYS A 1 308 ? 119.778 155.432 129.792 1.00 33.24  ?  192 CYS E N   1 
ATOM   1300 C CA  . CYS A 1 308 ? 119.836 156.404 128.706 1.00 34.30  ?  192 CYS E CA  1 
ATOM   1301 C C   . CYS A 1 308 ? 121.144 157.185 128.730 1.00 37.69  ?  192 CYS E C   1 
ATOM   1302 O O   . CYS A 1 308 ? 121.775 157.385 127.684 1.00 47.19  ?  192 CYS E O   1 
ATOM   1303 C CB  . CYS A 1 308 ? 118.642 157.352 128.787 1.00 45.28  ?  192 CYS E CB  1 
ATOM   1304 S SG  . CYS A 1 308 ? 117.052 156.581 128.404 1.00 73.82  ?  192 CYS E SG  1 
ATOM   1305 N N   . VAL A 1 309 ? 121.577 157.622 129.914 1.00 34.99  ?  193 VAL E N   1 
ATOM   1306 C CA  . VAL A 1 309 ? 122.802 158.408 129.999 1.00 38.31  ?  193 VAL E CA  1 
ATOM   1307 C C   . VAL A 1 309 ? 124.023 157.545 129.709 1.00 37.87  ?  193 VAL E C   1 
ATOM   1308 O O   . VAL A 1 309 ? 124.996 158.027 129.123 1.00 47.33  ?  193 VAL E O   1 
ATOM   1309 C CB  . VAL A 1 309 ? 122.901 159.117 131.365 1.00 42.56  ?  193 VAL E CB  1 
ATOM   1310 C CG1 . VAL A 1 309 ? 123.314 158.153 132.465 1.00 42.43  ?  193 VAL E CG1 1 
ATOM   1311 C CG2 . VAL A 1 309 ? 123.872 160.283 131.284 1.00 48.07  ?  193 VAL E CG2 1 
ATOM   1312 N N   . SER A 1 310 ? 123.999 156.263 130.086 1.00 33.68  ?  194 SER E N   1 
ATOM   1313 C CA  . SER A 1 310 ? 125.109 155.380 129.748 1.00 29.08  ?  194 SER E CA  1 
ATOM   1314 C C   . SER A 1 310 ? 125.215 155.185 128.243 1.00 34.99  ?  194 SER E C   1 
ATOM   1315 O O   . SER A 1 310 ? 126.314 155.240 127.678 1.00 44.03  ?  194 SER E O   1 
ATOM   1316 C CB  . SER A 1 310 ? 124.943 154.037 130.453 1.00 35.26  ?  194 SER E CB  1 
ATOM   1317 O OG  . SER A 1 310 ? 124.799 154.213 131.850 1.00 49.66  ?  194 SER E OG  1 
ATOM   1318 N N   . SER A 1 311 ? 124.080 154.966 127.573 1.00 27.16  ?  195 SER E N   1 
ATOM   1319 C CA  . SER A 1 311 ? 124.110 154.835 126.120 1.00 23.99  ?  195 SER E CA  1 
ATOM   1320 C C   . SER A 1 311 ? 124.594 156.122 125.462 1.00 35.23  ?  195 SER E C   1 
ATOM   1321 O O   . SER A 1 311 ? 125.391 156.085 124.515 1.00 44.32  ?  195 SER E O   1 
ATOM   1322 C CB  . SER A 1 311 ? 122.727 154.450 125.601 1.00 28.20  ?  195 SER E CB  1 
ATOM   1323 O OG  . SER A 1 311 ? 122.462 153.080 125.840 1.00 28.27  ?  195 SER E OG  1 
ATOM   1324 N N   . LEU A 1 312 ? 124.133 157.272 125.959 1.00 35.79  ?  196 LEU E N   1 
ATOM   1325 C CA  . LEU A 1 312 ? 124.554 158.545 125.383 1.00 32.42  ?  196 LEU E CA  1 
ATOM   1326 C C   . LEU A 1 312 ? 126.047 158.777 125.577 1.00 34.11  ?  196 LEU E C   1 
ATOM   1327 O O   . LEU A 1 312 ? 126.730 159.257 124.665 1.00 47.12  ?  196 LEU E O   1 
ATOM   1328 C CB  . LEU A 1 312 ? 123.748 159.688 125.997 1.00 38.07  ?  196 LEU E CB  1 
ATOM   1329 C CG  . LEU A 1 312 ? 122.662 160.297 125.109 1.00 39.58  ?  196 LEU E CG  1 
ATOM   1330 C CD1 . LEU A 1 312 ? 121.759 159.211 124.548 1.00 41.31  ?  196 LEU E CD1 1 
ATOM   1331 C CD2 . LEU A 1 312 ? 121.853 161.323 125.884 1.00 41.36  ?  196 LEU E CD2 1 
ATOM   1332 N N   . VAL A 1 313 ? 126.574 158.447 126.758 1.00 34.08  ?  197 VAL E N   1 
ATOM   1333 C CA  . VAL A 1 313 ? 127.998 158.632 127.014 1.00 31.96  ?  197 VAL E CA  1 
ATOM   1334 C C   . VAL A 1 313 ? 128.822 157.693 126.145 1.00 30.31  ?  197 VAL E C   1 
ATOM   1335 O O   . VAL A 1 313 ? 129.882 158.071 125.631 1.00 42.88  ?  197 VAL E O   1 
ATOM   1336 C CB  . VAL A 1 313 ? 128.300 158.440 128.511 1.00 40.71  ?  197 VAL E CB  1 
ATOM   1337 C CG1 . VAL A 1 313 ? 129.793 158.296 128.741 1.00 39.13  ?  197 VAL E CG1 1 
ATOM   1338 C CG2 . VAL A 1 313 ? 127.756 159.610 129.312 1.00 42.89  ?  197 VAL E CG2 1 
ATOM   1339 N N   . LEU A 1 314 ? 128.352 156.456 125.964 1.00 24.21  ?  198 LEU E N   1 
ATOM   1340 C CA  . LEU A 1 314 ? 129.043 155.536 125.068 1.00 28.72  ?  198 LEU E CA  1 
ATOM   1341 C C   . LEU A 1 314 ? 129.084 156.085 123.648 1.00 35.68  ?  198 LEU E C   1 
ATOM   1342 O O   . LEU A 1 314 ? 130.128 156.042 122.987 1.00 47.18  ?  198 LEU E O   1 
ATOM   1343 C CB  . LEU A 1 314 ? 128.360 154.169 125.100 1.00 37.19  ?  198 LEU E CB  1 
ATOM   1344 C CG  . LEU A 1 314 ? 128.548 153.239 123.902 1.00 38.12  ?  198 LEU E CG  1 
ATOM   1345 C CD1 . LEU A 1 314 ? 129.998 152.826 123.760 1.00 37.73  ?  198 LEU E CD1 1 
ATOM   1346 C CD2 . LEU A 1 314 ? 127.656 152.019 124.039 1.00 39.51  ?  198 LEU E CD2 1 
ATOM   1347 N N   . LEU A 1 315 ? 127.959 156.620 123.169 1.00 33.47  ?  199 LEU E N   1 
ATOM   1348 C CA  . LEU A 1 315 ? 127.932 157.192 121.826 1.00 28.21  ?  199 LEU E CA  1 
ATOM   1349 C C   . LEU A 1 315 ? 128.866 158.390 121.711 1.00 32.28  ?  199 LEU E C   1 
ATOM   1350 O O   . LEU A 1 315 ? 129.565 158.545 120.704 1.00 39.94  ?  199 LEU E O   1 
ATOM   1351 C CB  . LEU A 1 315 ? 126.506 157.587 121.454 1.00 35.72  ?  199 LEU E CB  1 
ATOM   1352 C CG  . LEU A 1 315 ? 125.832 156.619 120.487 1.00 41.56  ?  199 LEU E CG  1 
ATOM   1353 C CD1 . LEU A 1 315 ? 126.602 156.561 119.182 1.00 44.10  ?  199 LEU E CD1 1 
ATOM   1354 C CD2 . LEU A 1 315 ? 125.762 155.247 121.118 1.00 39.63  ?  199 LEU E CD2 1 
ATOM   1355 N N   . VAL A 1 316 ? 128.888 159.252 122.729 1.00 41.53  ?  200 VAL E N   1 
ATOM   1356 C CA  . VAL A 1 316 ? 129.756 160.426 122.686 1.00 41.93  ?  200 VAL E CA  1 
ATOM   1357 C C   . VAL A 1 316 ? 131.221 160.011 122.662 1.00 40.28  ?  200 VAL E C   1 
ATOM   1358 O O   . VAL A 1 316 ? 132.025 160.567 121.904 1.00 47.21  ?  200 VAL E O   1 
ATOM   1359 C CB  . VAL A 1 316 ? 129.451 161.364 123.869 1.00 45.32  ?  200 VAL E CB  1 
ATOM   1360 C CG1 . VAL A 1 316 ? 130.508 162.449 123.970 1.00 47.50  ?  200 VAL E CG1 1 
ATOM   1361 C CG2 . VAL A 1 316 ? 128.074 161.985 123.707 1.00 40.54  ?  200 VAL E CG2 1 
ATOM   1362 N N   . ARG A 1 317 ? 131.595 159.032 123.488 1.00 40.32  ?  201 ARG E N   1 
ATOM   1363 C CA  . ARG A 1 317 ? 132.981 158.575 123.504 1.00 41.44  ?  201 ARG E CA  1 
ATOM   1364 C C   . ARG A 1 317 ? 133.366 157.921 122.183 1.00 46.16  ?  201 ARG E C   1 
ATOM   1365 O O   . ARG A 1 317 ? 134.481 158.121 121.686 1.00 52.90  ?  201 ARG E O   1 
ATOM   1366 C CB  . ARG A 1 317 ? 133.207 157.609 124.667 1.00 41.66  ?  201 ARG E CB  1 
ATOM   1367 C CG  . ARG A 1 317 ? 134.650 157.149 124.816 1.00 46.37  ?  201 ARG E CG  1 
ATOM   1368 C CD  . ARG A 1 317 ? 135.499 158.186 125.536 1.00 49.41  ?  201 ARG E CD  1 
ATOM   1369 N NE  . ARG A 1 317 ? 136.451 158.832 124.641 1.00 53.26  ?  201 ARG E NE  1 
ATOM   1370 C CZ  . ARG A 1 317 ? 137.182 159.891 124.962 1.00 54.36  ?  201 ARG E CZ  1 
ATOM   1371 N NH1 . ARG A 1 317 ? 137.100 160.452 126.157 1.00 52.07  1  201 ARG E NH1 1 
ATOM   1372 N NH2 . ARG A 1 317 ? 138.016 160.401 124.060 1.00 44.17  ?  201 ARG E NH2 1 
ATOM   1373 N N   . ILE A 1 318 ? 132.463 157.129 121.601 1.00 44.00  ?  202 ILE E N   1 
ATOM   1374 C CA  . ILE A 1 318 ? 132.759 156.488 120.323 1.00 40.53  ?  202 ILE E CA  1 
ATOM   1375 C C   . ILE A 1 318 ? 132.880 157.526 119.214 1.00 49.50  ?  202 ILE E C   1 
ATOM   1376 O O   . ILE A 1 318 ? 133.768 157.439 118.358 1.00 58.93  ?  202 ILE E O   1 
ATOM   1377 C CB  . ILE A 1 318 ? 131.692 155.427 119.997 1.00 40.62  ?  202 ILE E CB  1 
ATOM   1378 C CG1 . ILE A 1 318 ? 131.874 154.203 120.896 1.00 45.14  ?  202 ILE E CG1 1 
ATOM   1379 C CG2 . ILE A 1 318 ? 131.750 155.035 118.530 1.00 45.72  ?  202 ILE E CG2 1 
ATOM   1380 C CD1 . ILE A 1 318 ? 132.910 153.223 120.396 1.00 43.17  ?  202 ILE E CD1 1 
ATOM   1381 N N   . LEU A 1 319 ? 132.006 158.529 119.217 1.00 46.71  ?  203 LEU E N   1 
ATOM   1382 C CA  . LEU A 1 319 ? 131.998 159.536 118.164 1.00 43.53  ?  203 LEU E CA  1 
ATOM   1383 C C   . LEU A 1 319 ? 133.025 160.640 118.382 1.00 46.21  ?  203 LEU E C   1 
ATOM   1384 O O   . LEU A 1 319 ? 133.126 161.540 117.542 1.00 44.66  ?  203 LEU E O   1 
ATOM   1385 C CB  . LEU A 1 319 ? 130.602 160.151 118.036 1.00 41.85  ?  203 LEU E CB  1 
ATOM   1386 C CG  . LEU A 1 319 ? 129.504 159.219 117.522 1.00 41.21  ?  203 LEU E CG  1 
ATOM   1387 C CD1 . LEU A 1 319 ? 128.371 160.018 116.899 1.00 45.45  ?  203 LEU E CD1 1 
ATOM   1388 C CD2 . LEU A 1 319 ? 130.066 158.214 116.528 1.00 45.15  ?  203 LEU E CD2 1 
ATOM   1389 N N   . CYS A 1 320 ? 133.778 160.602 119.477 1.00 61.49  ?  204 CYS E N   1 
ATOM   1390 C CA  . CYS A 1 320 ? 134.836 161.570 119.746 1.00 60.71  ?  204 CYS E CA  1 
ATOM   1391 C C   . CYS A 1 320 ? 136.207 160.901 119.745 1.00 64.90  ?  204 CYS E C   1 
ATOM   1392 O O   . CYS A 1 320 ? 137.070 161.208 120.570 1.00 66.17  ?  204 CYS E O   1 
ATOM   1393 C CB  . CYS A 1 320 ? 134.591 162.288 121.069 1.00 60.15  ?  204 CYS E CB  1 
ATOM   1394 S SG  . CYS A 1 320 ? 133.246 163.491 121.019 1.00 71.15  ?  204 CYS E SG  1 
ATOM   1395 N N   . GLY A 1 321 ? 136.417 159.975 118.813 1.00 72.39  ?  205 GLY E N   1 
ATOM   1396 C CA  . GLY A 1 321 ? 137.686 159.285 118.694 1.00 75.88  ?  205 GLY E CA  1 
ATOM   1397 C C   . GLY A 1 321 ? 137.995 158.878 117.268 1.00 78.79  ?  205 GLY E C   1 
ATOM   1398 O O   . GLY A 1 321 ? 137.297 159.290 116.336 1.00 78.78  ?  205 GLY E O   1 
ATOM   1399 N N   . SER A 1 322 ? 139.041 158.077 117.084 1.00 84.60  ?  206 SER E N   1 
ATOM   1400 C CA  . SER A 1 322 ? 139.399 157.604 115.756 1.00 81.94  ?  206 SER E CA  1 
ATOM   1401 C C   . SER A 1 322 ? 138.301 156.710 115.193 1.00 83.79  ?  206 SER E C   1 
ATOM   1402 O O   . SER A 1 322 ? 137.740 155.861 115.889 1.00 81.36  ?  206 SER E O   1 
ATOM   1403 C CB  . SER A 1 322 ? 140.720 156.840 115.796 1.00 80.37  ?  206 SER E CB  1 
ATOM   1404 O OG  . SER A 1 322 ? 140.505 155.483 116.144 1.00 84.02  ?  206 SER E OG  1 
ATOM   1405 N N   . ARG A 1 323 ? 137.999 156.910 113.914 1.00 88.95  ?  207 ARG E N   1 
ATOM   1406 C CA  . ARG A 1 323 ? 136.916 156.183 113.257 1.00 87.18  ?  207 ARG E CA  1 
ATOM   1407 C C   . ARG A 1 323 ? 137.469 154.922 112.607 1.00 88.46  ?  207 ARG E C   1 
ATOM   1408 O O   . ARG A 1 323 ? 137.830 154.922 111.429 1.00 90.18  ?  207 ARG E O   1 
ATOM   1409 C CB  . ARG A 1 323 ? 136.231 157.074 112.227 1.00 85.40  ?  207 ARG E CB  1 
ATOM   1410 N N   . LYS A 1 324 ? 137.539 153.836 113.375 1.00 95.20  ?  208 LYS E N   1 
ATOM   1411 C CA  . LYS A 1 324 ? 137.819 152.526 112.803 1.00 98.42  ?  208 LYS E CA  1 
ATOM   1412 C C   . LYS A 1 324 ? 136.730 152.080 111.840 1.00 100.04 ?  208 LYS E C   1 
ATOM   1413 O O   . LYS A 1 324 ? 136.977 151.210 110.997 1.00 101.91 ?  208 LYS E O   1 
ATOM   1414 C CB  . LYS A 1 324 ? 137.986 151.486 113.914 1.00 95.94  ?  208 LYS E CB  1 
ATOM   1415 N N   . MET A 1 325 ? 135.535 152.651 111.966 1.00 94.96  ?  209 MET E N   1 
ATOM   1416 C CA  . MET A 1 325 ? 134.377 152.489 111.098 1.00 94.41  ?  209 MET E CA  1 
ATOM   1417 C C   . MET A 1 325 ? 133.817 151.073 110.974 1.00 95.09  ?  209 MET E C   1 
ATOM   1418 O O   . MET A 1 325 ? 133.517 150.640 109.855 1.00 95.31  ?  209 MET E O   1 
ATOM   1419 C CB  . MET A 1 325 ? 134.716 153.006 109.697 1.00 94.40  ?  209 MET E CB  1 
ATOM   1420 N N   . PRO A 1 326 ? 133.654 150.308 112.071 1.00 92.22  ?  210 PRO E N   1 
ATOM   1421 C CA  . PRO A 1 326 ? 132.489 149.415 112.123 1.00 90.99  ?  210 PRO E CA  1 
ATOM   1422 C C   . PRO A 1 326 ? 131.310 150.179 112.701 1.00 90.72  ?  210 PRO E C   1 
ATOM   1423 O O   . PRO A 1 326 ? 130.573 149.655 113.542 1.00 87.21  ?  210 PRO E O   1 
ATOM   1424 C CB  . PRO A 1 326 ? 132.921 148.268 113.046 1.00 89.76  ?  210 PRO E CB  1 
ATOM   1425 C CG  . PRO A 1 326 ? 134.228 148.623 113.593 1.00 92.04  ?  210 PRO E CG  1 
ATOM   1426 C CD  . PRO A 1 326 ? 134.718 149.896 113.005 1.00 90.24  ?  210 PRO E CD  1 
ATOM   1427 N N   . LEU A 1 327 ? 131.120 151.421 112.254 1.00 81.96  ?  211 LEU E N   1 
ATOM   1428 C CA  . LEU A 1 327 ? 130.146 152.293 112.895 1.00 80.59  ?  211 LEU E CA  1 
ATOM   1429 C C   . LEU A 1 327 ? 128.797 152.183 112.205 1.00 79.15  ?  211 LEU E C   1 
ATOM   1430 O O   . LEU A 1 327 ? 128.149 153.194 111.917 1.00 81.97  ?  211 LEU E O   1 
ATOM   1431 C CB  . LEU A 1 327 ? 130.641 153.741 112.885 1.00 80.68  ?  211 LEU E CB  1 
ATOM   1432 C CG  . LEU A 1 327 ? 131.845 154.069 113.774 1.00 79.10  ?  211 LEU E CG  1 
ATOM   1433 C CD1 . LEU A 1 327 ? 131.781 155.511 114.251 1.00 78.86  ?  211 LEU E CD1 1 
ATOM   1434 C CD2 . LEU A 1 327 ? 131.940 153.119 114.959 1.00 76.53  ?  211 LEU E CD2 1 
ATOM   1435 N N   . THR A 1 328 ? 128.375 150.965 111.945 1.00 71.26  ?  212 THR E N   1 
ATOM   1436 C CA  . THR A 1 328 ? 127.012 150.618 111.571 1.00 74.22  ?  212 THR E CA  1 
ATOM   1437 C C   . THR A 1 328 ? 126.470 149.504 112.447 1.00 73.85  ?  212 THR E C   1 
ATOM   1438 O O   . THR A 1 328 ? 125.289 149.525 112.800 1.00 77.59  ?  212 THR E O   1 
ATOM   1439 C CB  . THR A 1 328 ? 126.923 150.198 110.092 1.00 77.06  ?  212 THR E CB  1 
ATOM   1440 O OG1 . THR A 1 328 ? 127.371 148.844 109.950 1.00 77.42  ?  212 THR E OG1 1 
ATOM   1441 C CG2 . THR A 1 328 ? 127.773 151.107 109.213 1.00 75.48  ?  212 THR E CG2 1 
ATOM   1442 N N   . ARG A 1 329 ? 127.311 148.532 112.807 1.00 67.15  ?  213 ARG E N   1 
ATOM   1443 C CA  . ARG A 1 329 ? 126.924 147.539 113.800 1.00 64.22  ?  213 ARG E CA  1 
ATOM   1444 C C   . ARG A 1 329 ? 126.725 148.185 115.163 1.00 68.43  ?  213 ARG E C   1 
ATOM   1445 O O   . ARG A 1 329 ? 125.782 147.847 115.885 1.00 72.33  ?  213 ARG E O   1 
ATOM   1446 C CB  . ARG A 1 329 ? 127.981 146.435 113.871 1.00 66.36  ?  213 ARG E CB  1 
ATOM   1447 C CG  . ARG A 1 329 ? 127.649 145.272 114.799 1.00 72.00  ?  213 ARG E CG  1 
ATOM   1448 C CD  . ARG A 1 329 ? 128.270 145.459 116.181 1.00 76.14  ?  213 ARG E CD  1 
ATOM   1449 N NE  . ARG A 1 329 ? 129.728 145.447 116.140 1.00 76.95  ?  213 ARG E NE  1 
ATOM   1450 C CZ  . ARG A 1 329 ? 130.508 145.618 117.198 1.00 71.22  ?  213 ARG E CZ  1 
ATOM   1451 N NH1 . ARG A 1 329 ? 130.003 145.808 118.406 1.00 67.88  1  213 ARG E NH1 1 
ATOM   1452 N NH2 . ARG A 1 329 ? 131.829 145.600 117.041 1.00 66.22  ?  213 ARG E NH2 1 
ATOM   1453 N N   . LEU A 1 330 ? 127.610 149.112 115.536 1.00 62.45  ?  214 LEU E N   1 
ATOM   1454 C CA  . LEU A 1 330 ? 127.474 149.790 116.822 1.00 60.10  ?  214 LEU E CA  1 
ATOM   1455 C C   . LEU A 1 330 ? 126.221 150.655 116.863 1.00 61.08  ?  214 LEU E C   1 
ATOM   1456 O O   . LEU A 1 330 ? 125.530 150.706 117.886 1.00 60.64  ?  214 LEU E O   1 
ATOM   1457 C CB  . LEU A 1 330 ? 128.718 150.631 117.108 1.00 58.98  ?  214 LEU E CB  1 
ATOM   1458 C CG  . LEU A 1 330 ? 128.640 151.576 118.308 1.00 52.50  ?  214 LEU E CG  1 
ATOM   1459 C CD1 . LEU A 1 330 ? 129.882 151.437 119.165 1.00 56.48  ?  214 LEU E CD1 1 
ATOM   1460 C CD2 . LEU A 1 330 ? 128.466 153.014 117.856 1.00 56.59  ?  214 LEU E CD2 1 
ATOM   1461 N N   . TYR A 1 331 ? 125.921 151.353 115.766 1.00 65.68  ?  215 TYR E N   1 
ATOM   1462 C CA  . TYR A 1 331 ? 124.722 152.184 115.725 1.00 62.64  ?  215 TYR E CA  1 
ATOM   1463 C C   . TYR A 1 331 ? 123.467 151.340 115.894 1.00 59.39  ?  215 TYR E C   1 
ATOM   1464 O O   . TYR A 1 331 ? 122.591 151.661 116.708 1.00 62.22  ?  215 TYR E O   1 
ATOM   1465 C CB  . TYR A 1 331 ? 124.668 152.963 114.410 1.00 63.92  ?  215 TYR E CB  1 
ATOM   1466 C CG  . TYR A 1 331 ? 125.487 154.237 114.401 1.00 68.00  ?  215 TYR E CG  1 
ATOM   1467 C CD1 . TYR A 1 331 ? 126.456 154.474 115.366 1.00 68.55  ?  215 TYR E CD1 1 
ATOM   1468 C CD2 . TYR A 1 331 ? 125.286 155.203 113.424 1.00 64.76  ?  215 TYR E CD2 1 
ATOM   1469 C CE1 . TYR A 1 331 ? 127.203 155.635 115.357 1.00 65.08  ?  215 TYR E CE1 1 
ATOM   1470 C CE2 . TYR A 1 331 ? 126.027 156.366 113.408 1.00 66.68  ?  215 TYR E CE2 1 
ATOM   1471 C CZ  . TYR A 1 331 ? 126.984 156.577 114.376 1.00 67.78  ?  215 TYR E CZ  1 
ATOM   1472 O OH  . TYR A 1 331 ? 127.723 157.737 114.362 1.00 69.29  ?  215 TYR E OH  1 
ATOM   1473 N N   . VAL A 1 332 ? 123.372 150.239 115.146 1.00 59.29  ?  216 VAL E N   1 
ATOM   1474 C CA  . VAL A 1 332 ? 122.134 149.468 115.140 1.00 61.02  ?  216 VAL E CA  1 
ATOM   1475 C C   . VAL A 1 332 ? 121.919 148.781 116.483 1.00 61.64  ?  216 VAL E C   1 
ATOM   1476 O O   . VAL A 1 332 ? 120.793 148.730 116.982 1.00 67.12  ?  216 VAL E O   1 
ATOM   1477 C CB  . VAL A 1 332 ? 122.111 148.464 113.970 1.00 64.93  ?  216 VAL E CB  1 
ATOM   1478 C CG1 . VAL A 1 332 ? 123.265 147.483 114.052 1.00 64.17  ?  216 VAL E CG1 1 
ATOM   1479 C CG2 . VAL A 1 332 ? 120.781 147.726 113.928 1.00 66.33  ?  216 VAL E CG2 1 
ATOM   1480 N N   . THR A 1 333 ? 122.983 148.263 117.105 1.00 59.02  ?  217 THR E N   1 
ATOM   1481 C CA  . THR A 1 333 ? 122.793 147.536 118.358 1.00 61.49  ?  217 THR E CA  1 
ATOM   1482 C C   . THR A 1 333 ? 122.366 148.476 119.480 1.00 65.17  ?  217 THR E C   1 
ATOM   1483 O O   . THR A 1 333 ? 121.439 148.168 120.238 1.00 69.29  ?  217 THR E O   1 
ATOM   1484 C CB  . THR A 1 333 ? 124.058 146.761 118.745 1.00 64.53  ?  217 THR E CB  1 
ATOM   1485 O OG1 . THR A 1 333 ? 123.849 146.114 120.006 1.00 70.59  ?  217 THR E OG1 1 
ATOM   1486 C CG2 . THR A 1 333 ? 125.264 147.674 118.870 1.00 61.43  ?  217 THR E CG2 1 
ATOM   1487 N N   . ILE A 1 334 ? 123.016 149.637 119.593 1.00 55.01  ?  218 ILE E N   1 
ATOM   1488 C CA  . ILE A 1 334 ? 122.645 150.590 120.634 1.00 55.81  ?  218 ILE E CA  1 
ATOM   1489 C C   . ILE A 1 334 ? 121.243 151.126 120.386 1.00 58.48  ?  218 ILE E C   1 
ATOM   1490 O O   . ILE A 1 334 ? 120.429 151.231 121.314 1.00 60.91  ?  218 ILE E O   1 
ATOM   1491 C CB  . ILE A 1 334 ? 123.681 151.725 120.722 1.00 51.76  ?  218 ILE E CB  1 
ATOM   1492 C CG1 . ILE A 1 334 ? 124.691 151.443 121.834 1.00 55.41  ?  218 ILE E CG1 1 
ATOM   1493 C CG2 . ILE A 1 334 ? 122.999 153.054 120.986 1.00 50.20  ?  218 ILE E CG2 1 
ATOM   1494 C CD1 . ILE A 1 334 ? 125.483 150.172 121.641 1.00 63.31  ?  218 ILE E CD1 1 
ATOM   1495 N N   . LEU A 1 335 ? 120.933 151.463 119.131 1.00 66.49  ?  219 LEU E N   1 
ATOM   1496 C CA  . LEU A 1 335 ? 119.602 151.968 118.821 1.00 63.55  ?  219 LEU E CA  1 
ATOM   1497 C C   . LEU A 1 335 ? 118.540 150.923 119.124 1.00 64.17  ?  219 LEU E C   1 
ATOM   1498 O O   . LEU A 1 335 ? 117.489 151.245 119.686 1.00 69.70  ?  219 LEU E O   1 
ATOM   1499 C CB  . LEU A 1 335 ? 119.529 152.406 117.360 1.00 66.43  ?  219 LEU E CB  1 
ATOM   1500 C CG  . LEU A 1 335 ? 118.684 153.648 117.071 1.00 62.48  ?  219 LEU E CG  1 
ATOM   1501 C CD1 . LEU A 1 335 ? 118.708 154.608 118.250 1.00 63.45  ?  219 LEU E CD1 1 
ATOM   1502 C CD2 . LEU A 1 335 ? 119.165 154.338 115.805 1.00 62.67  ?  219 LEU E CD2 1 
ATOM   1503 N N   . LEU A 1 336 ? 118.802 149.662 118.776 1.00 60.01  ?  220 LEU E N   1 
ATOM   1504 C CA  . LEU A 1 336 ? 117.837 148.601 119.029 1.00 57.51  ?  220 LEU E CA  1 
ATOM   1505 C C   . LEU A 1 336 ? 117.654 148.359 120.520 1.00 58.33  ?  220 LEU E C   1 
ATOM   1506 O O   . LEU A 1 336 ? 116.527 148.153 120.979 1.00 65.98  ?  220 LEU E O   1 
ATOM   1507 C CB  . LEU A 1 336 ? 118.275 147.318 118.325 1.00 59.09  ?  220 LEU E CB  1 
ATOM   1508 C CG  . LEU A 1 336 ? 117.167 146.309 118.019 1.00 61.86  ?  220 LEU E CG  1 
ATOM   1509 C CD1 . LEU A 1 336 ? 116.216 146.860 116.969 1.00 68.55  ?  220 LEU E CD1 1 
ATOM   1510 C CD2 . LEU A 1 336 ? 117.761 144.988 117.561 1.00 59.58  ?  220 LEU E CD2 1 
ATOM   1511 N N   . THR A 1 337 ? 118.741 148.377 121.294 1.00 58.56  ?  221 THR E N   1 
ATOM   1512 C CA  . THR A 1 337 ? 118.614 148.175 122.735 1.00 61.55  ?  221 THR E CA  1 
ATOM   1513 C C   . THR A 1 337 ? 117.810 149.300 123.374 1.00 63.31  ?  221 THR E C   1 
ATOM   1514 O O   . THR A 1 337 ? 116.889 149.054 124.164 1.00 68.82  ?  221 THR E O   1 
ATOM   1515 C CB  . THR A 1 337 ? 119.994 148.069 123.382 1.00 63.47  ?  221 THR E CB  1 
ATOM   1516 O OG1 . THR A 1 337 ? 120.812 149.162 122.950 1.00 66.99  ?  221 THR E OG1 1 
ATOM   1517 C CG2 . THR A 1 337 ? 120.662 146.757 123.001 1.00 65.70  ?  221 THR E CG2 1 
ATOM   1518 N N   . VAL A 1 338 ? 118.128 150.548 123.024 1.00 60.85  ?  222 VAL E N   1 
ATOM   1519 C CA  . VAL A 1 338 ? 117.393 151.673 123.591 1.00 60.17  ?  222 VAL E CA  1 
ATOM   1520 C C   . VAL A 1 338 ? 115.932 151.630 123.162 1.00 63.93  ?  222 VAL E C   1 
ATOM   1521 O O   . VAL A 1 338 ? 115.029 151.886 123.966 1.00 67.97  ?  222 VAL E O   1 
ATOM   1522 C CB  . VAL A 1 338 ? 118.066 153.001 123.205 1.00 65.48  ?  222 VAL E CB  1 
ATOM   1523 C CG1 . VAL A 1 338 ? 117.246 154.176 123.707 1.00 71.34  ?  222 VAL E CG1 1 
ATOM   1524 C CG2 . VAL A 1 338 ? 119.474 153.061 123.773 1.00 62.69  ?  222 VAL E CG2 1 
ATOM   1525 N N   . LEU A 1 339 ? 115.671 151.301 121.895 1.00 58.87  ?  223 LEU E N   1 
ATOM   1526 C CA  . LEU A 1 339 ? 114.297 151.258 121.409 1.00 59.19  ?  223 LEU E CA  1 
ATOM   1527 C C   . LEU A 1 339 ? 113.502 150.146 122.080 1.00 63.53  ?  223 LEU E C   1 
ATOM   1528 O O   . LEU A 1 339 ? 112.339 150.344 122.443 1.00 72.23  ?  223 LEU E O   1 
ATOM   1529 C CB  . LEU A 1 339 ? 114.288 151.085 119.893 1.00 65.19  ?  223 LEU E CB  1 
ATOM   1530 C CG  . LEU A 1 339 ? 113.120 151.739 119.156 1.00 68.17  ?  223 LEU E CG  1 
ATOM   1531 C CD1 . LEU A 1 339 ? 113.327 153.241 119.066 1.00 66.38  ?  223 LEU E CD1 1 
ATOM   1532 C CD2 . LEU A 1 339 ? 112.960 151.134 117.771 1.00 68.61  ?  223 LEU E CD2 1 
ATOM   1533 N N   . VAL A 1 340 ? 114.109 148.971 122.261 1.00 48.31  ?  224 VAL E N   1 
ATOM   1534 C CA  . VAL A 1 340 ? 113.392 147.867 122.878 1.00 50.33  ?  224 VAL E CA  1 
ATOM   1535 C C   . VAL A 1 340 ? 113.265 148.067 124.380 1.00 56.40  ?  224 VAL E C   1 
ATOM   1536 O O   . VAL A 1 340 ? 112.452 147.395 125.023 1.00 64.73  ?  224 VAL E O   1 
ATOM   1537 C CB  . VAL A 1 340 ? 114.080 146.526 122.557 1.00 54.34  ?  224 VAL E CB  1 
ATOM   1538 C CG1 . VAL A 1 340 ? 115.348 146.360 123.379 1.00 54.81  ?  224 VAL E CG1 1 
ATOM   1539 C CG2 . VAL A 1 340 ? 113.123 145.359 122.761 1.00 57.39  ?  224 VAL E CG2 1 
ATOM   1540 N N   . PHE A 1 341 ? 114.056 148.967 124.966 1.00 54.56  ?  225 PHE E N   1 
ATOM   1541 C CA  . PHE A 1 341 ? 113.856 149.304 126.370 1.00 49.91  ?  225 PHE E CA  1 
ATOM   1542 C C   . PHE A 1 341 ? 112.788 150.373 126.567 1.00 50.24  ?  225 PHE E C   1 
ATOM   1543 O O   . PHE A 1 341 ? 112.001 150.283 127.514 1.00 61.99  ?  225 PHE E O   1 
ATOM   1544 C CB  . PHE A 1 341 ? 115.175 149.758 127.000 1.00 56.50  ?  225 PHE E CB  1 
ATOM   1545 C CG  . PHE A 1 341 ? 115.162 149.776 128.507 1.00 58.65  ?  225 PHE E CG  1 
ATOM   1546 C CD1 . PHE A 1 341 ? 114.447 150.738 129.205 1.00 52.93  ?  225 PHE E CD1 1 
ATOM   1547 C CD2 . PHE A 1 341 ? 115.855 148.820 129.226 1.00 61.75  ?  225 PHE E CD2 1 
ATOM   1548 C CE1 . PHE A 1 341 ? 114.433 150.751 130.583 1.00 50.78  ?  225 PHE E CE1 1 
ATOM   1549 C CE2 . PHE A 1 341 ? 115.847 148.830 130.607 1.00 61.86  ?  225 PHE E CE2 1 
ATOM   1550 C CZ  . PHE A 1 341 ? 115.134 149.796 131.286 1.00 56.78  ?  225 PHE E CZ  1 
ATOM   1551 N N   . LEU A 1 342 ? 112.737 151.389 125.706 1.00 45.09  ?  226 LEU E N   1 
ATOM   1552 C CA  . LEU A 1 342 ? 111.753 152.449 125.911 1.00 54.71  ?  226 LEU E CA  1 
ATOM   1553 C C   . LEU A 1 342 ? 110.398 152.091 125.310 1.00 61.29  ?  226 LEU E C   1 
ATOM   1554 O O   . LEU A 1 342 ? 109.373 152.163 125.995 1.00 66.10  ?  226 LEU E O   1 
ATOM   1555 C CB  . LEU A 1 342 ? 112.257 153.779 125.345 1.00 59.55  ?  226 LEU E CB  1 
ATOM   1556 C CG  . LEU A 1 342 ? 113.731 154.146 125.507 1.00 61.95  ?  226 LEU E CG  1 
ATOM   1557 C CD1 . LEU A 1 342 ? 113.999 155.530 124.942 1.00 61.83  ?  226 LEU E CD1 1 
ATOM   1558 C CD2 . LEU A 1 342 ? 114.146 154.078 126.968 1.00 62.12  ?  226 LEU E CD2 1 
ATOM   1559 N N   . LEU A 1 343 ? 110.368 151.715 124.031 1.00 58.19  ?  227 LEU E N   1 
ATOM   1560 C CA  . LEU A 1 343 ? 109.101 151.395 123.385 1.00 56.93  ?  227 LEU E CA  1 
ATOM   1561 C C   . LEU A 1 343 ? 108.493 150.099 123.904 1.00 61.09  ?  227 LEU E C   1 
ATOM   1562 O O   . LEU A 1 343 ? 107.278 149.911 123.788 1.00 70.15  ?  227 LEU E O   1 
ATOM   1563 C CB  . LEU A 1 343 ? 109.288 151.308 121.871 1.00 60.26  ?  227 LEU E CB  1 
ATOM   1564 C CG  . LEU A 1 343 ? 109.020 152.586 121.073 1.00 67.00  ?  227 LEU E CG  1 
ATOM   1565 C CD1 . LEU A 1 343 ? 110.056 153.654 121.382 1.00 64.36  ?  227 LEU E CD1 1 
ATOM   1566 C CD2 . LEU A 1 343 ? 108.988 152.284 119.584 1.00 67.65  ?  227 LEU E CD2 1 
ATOM   1567 N N   . CYS A 1 344 ? 109.302 149.206 124.467 1.00 57.23  ?  228 CYS E N   1 
ATOM   1568 C CA  . CYS A 1 344 ? 108.821 147.950 125.018 1.00 56.02  ?  228 CYS E CA  1 
ATOM   1569 C C   . CYS A 1 344 ? 109.410 147.748 126.406 1.00 59.91  ?  228 CYS E C   1 
ATOM   1570 O O   . CYS A 1 344 ? 110.522 148.192 126.694 1.00 65.67  ?  228 CYS E O   1 
ATOM   1571 C CB  . CYS A 1 344 ? 109.187 146.770 124.113 1.00 55.03  ?  228 CYS E CB  1 
ATOM   1572 S SG  . CYS A 1 344 ? 108.230 146.669 122.586 1.00 71.04  ?  228 CYS E SG  1 
ATOM   1573 N N   . GLY A 1 345 ? 108.654 147.080 127.270 1.00 65.69  ?  229 GLY E N   1 
ATOM   1574 C CA  . GLY A 1 345 ? 109.118 146.852 128.624 1.00 64.63  ?  229 GLY E CA  1 
ATOM   1575 C C   . GLY A 1 345 ? 108.832 148.015 129.550 1.00 59.07  ?  229 GLY E C   1 
ATOM   1576 O O   . GLY A 1 345 ? 108.049 147.882 130.495 1.00 69.48  ?  229 GLY E O   1 
ATOM   1577 N N   . LEU A 1 346 ? 109.458 149.161 129.289 1.00 37.89  ?  230 LEU E N   1 
ATOM   1578 C CA  . LEU A 1 346 ? 109.163 150.359 130.071 1.00 41.18  ?  230 LEU E CA  1 
ATOM   1579 C C   . LEU A 1 346 ? 107.681 150.716 130.100 1.00 49.02  ?  230 LEU E C   1 
ATOM   1580 O O   . LEU A 1 346 ? 107.224 151.229 131.137 1.00 61.81  ?  230 LEU E O   1 
ATOM   1581 C CB  . LEU A 1 346 ? 109.988 151.543 129.555 1.00 46.75  ?  230 LEU E CB  1 
ATOM   1582 C CG  . LEU A 1 346 ? 110.242 152.650 130.579 1.00 53.32  ?  230 LEU E CG  1 
ATOM   1583 C CD1 . LEU A 1 346 ? 111.238 152.191 131.629 1.00 54.61  ?  230 LEU E CD1 1 
ATOM   1584 C CD2 . LEU A 1 346 ? 110.725 153.916 129.895 1.00 55.48  ?  230 LEU E CD2 1 
ATOM   1585 N N   . PRO A 1 347 ? 106.898 150.530 129.027 1.00 39.93  ?  231 PRO E N   1 
ATOM   1586 C CA  . PRO A 1 347 ? 105.452 150.763 129.152 1.00 44.35  ?  231 PRO E CA  1 
ATOM   1587 C C   . PRO A 1 347 ? 104.804 149.981 130.281 1.00 55.65  ?  231 PRO E C   1 
ATOM   1588 O O   . PRO A 1 347 ? 103.918 150.518 130.948 1.00 59.61  ?  231 PRO E O   1 
ATOM   1589 C CB  . PRO A 1 347 ? 104.919 150.336 127.781 1.00 52.94  ?  231 PRO E CB  1 
ATOM   1590 C CG  . PRO A 1 347 ? 106.022 150.651 126.859 1.00 54.63  ?  231 PRO E CG  1 
ATOM   1591 C CD  . PRO A 1 347 ? 107.290 150.362 127.615 1.00 50.01  ?  231 PRO E CD  1 
ATOM   1592 N N   . PHE A 1 348 ? 105.228 148.740 130.531 1.00 62.65  ?  232 PHE E N   1 
ATOM   1593 C CA  . PHE A 1 348 ? 104.668 147.981 131.648 1.00 56.63  ?  232 PHE E CA  1 
ATOM   1594 C C   . PHE A 1 348 ? 104.973 148.651 132.983 1.00 52.00  ?  232 PHE E C   1 
ATOM   1595 O O   . PHE A 1 348 ? 104.092 148.774 133.845 1.00 58.21  ?  232 PHE E O   1 
ATOM   1596 C CB  . PHE A 1 348 ? 105.211 146.552 131.630 1.00 56.61  ?  232 PHE E CB  1 
ATOM   1597 C CG  . PHE A 1 348 ? 104.296 145.543 132.264 1.00 55.39  ?  232 PHE E CG  1 
ATOM   1598 C CD1 . PHE A 1 348 ? 103.012 145.351 131.783 1.00 57.50  ?  232 PHE E CD1 1 
ATOM   1599 C CD2 . PHE A 1 348 ? 104.724 144.779 133.334 1.00 53.54  ?  232 PHE E CD2 1 
ATOM   1600 C CE1 . PHE A 1 348 ? 102.172 144.421 132.362 1.00 53.77  ?  232 PHE E CE1 1 
ATOM   1601 C CE2 . PHE A 1 348 ? 103.889 143.847 133.917 1.00 53.53  ?  232 PHE E CE2 1 
ATOM   1602 C CZ  . PHE A 1 348 ? 102.612 143.669 133.430 1.00 52.83  ?  232 PHE E CZ  1 
ATOM   1603 N N   . GLY A 1 349 ? 106.217 149.094 133.169 1.00 54.40  ?  233 GLY E N   1 
ATOM   1604 C CA  . GLY A 1 349 ? 106.579 149.740 134.419 1.00 58.71  ?  233 GLY E CA  1 
ATOM   1605 C C   . GLY A 1 349 ? 105.832 151.040 134.637 1.00 53.91  ?  233 GLY E C   1 
ATOM   1606 O O   . GLY A 1 349 ? 105.299 151.290 135.721 1.00 54.67  ?  233 GLY E O   1 
ATOM   1607 N N   . ILE A 1 350 ? 105.771 151.883 133.603 1.00 52.12  ?  234 ILE E N   1 
ATOM   1608 C CA  . ILE A 1 350 ? 105.051 153.142 133.757 1.00 60.90  ?  234 ILE E CA  1 
ATOM   1609 C C   . ILE A 1 350 ? 103.559 152.888 133.924 1.00 67.42  ?  234 ILE E C   1 
ATOM   1610 O O   . ILE A 1 350 ? 102.870 153.648 134.615 1.00 76.52  ?  234 ILE E O   1 
ATOM   1611 C CB  . ILE A 1 350 ? 105.338 154.095 132.581 1.00 61.34  ?  234 ILE E CB  1 
ATOM   1612 C CG1 . ILE A 1 350 ? 104.727 153.566 131.284 1.00 62.81  ?  234 ILE E CG1 1 
ATOM   1613 C CG2 . ILE A 1 350 ? 106.835 154.301 132.423 1.00 61.08  ?  234 ILE E CG2 1 
ATOM   1614 C CD1 . ILE A 1 350 ? 105.077 154.385 130.063 1.00 63.83  ?  234 ILE E CD1 1 
ATOM   1615 N N   . LEU A 1 351 ? 103.038 151.818 133.315 1.00 65.88  ?  235 LEU E N   1 
ATOM   1616 C CA  . LEU A 1 351 ? 101.633 151.468 133.483 1.00 65.77  ?  235 LEU E CA  1 
ATOM   1617 C C   . LEU A 1 351 ? 101.336 151.115 134.929 1.00 58.08  ?  235 LEU E C   1 
ATOM   1618 O O   . LEU A 1 351 ? 100.375 151.620 135.517 1.00 60.55  ?  235 LEU E O   1 
ATOM   1619 C CB  . LEU A 1 351 ? 101.271 150.307 132.560 1.00 67.81  ?  235 LEU E CB  1 
ATOM   1620 C CG  . LEU A 1 351 ? 100.098 149.441 133.017 1.00 65.01  ?  235 LEU E CG  1 
ATOM   1621 C CD1 . LEU A 1 351 ? 98.772  150.104 132.678 1.00 65.56  ?  235 LEU E CD1 1 
ATOM   1622 C CD2 . LEU A 1 351 ? 100.193 148.064 132.397 1.00 62.72  ?  235 LEU E CD2 1 
ATOM   1623 N N   . GLY A 1 352 ? 102.160 150.253 135.522 1.00 59.76  ?  236 GLY E N   1 
ATOM   1624 C CA  . GLY A 1 352 ? 102.001 149.962 136.937 1.00 66.24  ?  236 GLY E CA  1 
ATOM   1625 C C   . GLY A 1 352 ? 102.138 151.205 137.794 1.00 69.81  ?  236 GLY E C   1 
ATOM   1626 O O   . GLY A 1 352 ? 101.371 151.411 138.743 1.00 67.16  ?  236 GLY E O   1 
ATOM   1627 N N   . ALA A 1 353 ? 103.097 152.068 137.449 1.00 76.14  ?  237 ALA E N   1 
ATOM   1628 C CA  . ALA A 1 353 ? 103.338 153.274 138.232 1.00 73.74  ?  237 ALA E CA  1 
ATOM   1629 C C   . ALA A 1 353 ? 102.113 154.180 138.252 1.00 71.04  ?  237 ALA E C   1 
ATOM   1630 O O   . ALA A 1 353 ? 101.648 154.582 139.323 1.00 76.62  ?  237 ALA E O   1 
ATOM   1631 C CB  . ALA A 1 353 ? 104.553 154.021 137.682 1.00 75.38  ?  237 ALA E CB  1 
ATOM   1632 N N   . LEU A 1 354 ? 101.563 154.509 137.083 1.00 67.82  ?  238 LEU E N   1 
ATOM   1633 C CA  . LEU A 1 354 ? 100.443 155.441 137.113 1.00 71.24  ?  238 LEU E CA  1 
ATOM   1634 C C   . LEU A 1 354 ? 99.112  154.740 137.351 1.00 79.27  ?  238 LEU E C   1 
ATOM   1635 O O   . LEU A 1 354 ? 98.092  155.422 137.495 1.00 80.86  ?  238 LEU E O   1 
ATOM   1636 C CB  . LEU A 1 354 ? 100.354 156.281 135.830 1.00 72.37  ?  238 LEU E CB  1 
ATOM   1637 C CG  . LEU A 1 354 ? 99.662  155.852 134.528 1.00 73.66  ?  238 LEU E CG  1 
ATOM   1638 C CD1 . LEU A 1 354 ? 99.905  156.893 133.436 1.00 76.42  ?  238 LEU E CD1 1 
ATOM   1639 C CD2 . LEU A 1 354 ? 100.014 154.473 134.041 1.00 73.11  ?  238 LEU E CD2 1 
ATOM   1640 N N   . ILE A 1 355 ? 99.089  153.405 137.392 1.00 80.80  ?  239 ILE E N   1 
ATOM   1641 C CA  . ILE A 1 355 ? 97.877  152.697 137.781 1.00 76.56  ?  239 ILE E CA  1 
ATOM   1642 C C   . ILE A 1 355 ? 97.798  152.491 139.286 1.00 75.95  ?  239 ILE E C   1 
ATOM   1643 O O   . ILE A 1 355 ? 96.697  152.282 139.815 1.00 80.94  ?  239 ILE E O   1 
ATOM   1644 C CB  . ILE A 1 355 ? 97.766  151.343 137.056 1.00 77.96  ?  239 ILE E CB  1 
ATOM   1645 C CG1 . ILE A 1 355 ? 96.300  150.942 136.894 1.00 78.03  ?  239 ILE E CG1 1 
ATOM   1646 C CG2 . ILE A 1 355 ? 98.512  150.258 137.812 1.00 79.67  ?  239 ILE E CG2 1 
ATOM   1647 C CD1 . ILE A 1 355 ? 96.109  149.594 136.233 1.00 77.23  ?  239 ILE E CD1 1 
ATOM   1648 N N   . TYR A 1 356 ? 98.927  152.539 139.996 1.00 82.07  ?  240 TYR E N   1 
ATOM   1649 C CA  . TYR A 1 356 ? 98.863  152.535 141.450 1.00 88.10  ?  240 TYR E CA  1 
ATOM   1650 C C   . TYR A 1 356 ? 99.017  153.928 142.050 1.00 89.72  ?  240 TYR E C   1 
ATOM   1651 O O   . TYR A 1 356 ? 98.639  154.128 143.209 1.00 88.36  ?  240 TYR E O   1 
ATOM   1652 C CB  . TYR A 1 356 ? 99.914  151.584 142.043 1.00 89.25  ?  240 TYR E CB  1 
ATOM   1653 C CG  . TYR A 1 356 ? 101.211 152.231 142.463 1.00 88.47  ?  240 TYR E CG  1 
ATOM   1654 C CD1 . TYR A 1 356 ? 102.196 152.535 141.536 1.00 88.99  ?  240 TYR E CD1 1 
ATOM   1655 C CD2 . TYR A 1 356 ? 101.450 152.532 143.796 1.00 84.49  ?  240 TYR E CD2 1 
ATOM   1656 C CE1 . TYR A 1 356 ? 103.382 153.124 141.928 1.00 91.62  ?  240 TYR E CE1 1 
ATOM   1657 C CE2 . TYR A 1 356 ? 102.625 153.122 144.192 1.00 85.56  ?  240 TYR E CE2 1 
ATOM   1658 C CZ  . TYR A 1 356 ? 103.589 153.412 143.260 1.00 90.14  ?  240 TYR E CZ  1 
ATOM   1659 O OH  . TYR A 1 356 ? 104.762 154.001 143.671 1.00 87.69  ?  240 TYR E OH  1 
ATOM   1660 N N   . ARG A 1 357 ? 99.556  154.892 141.297 1.00 84.52  ?  241 ARG E N   1 
ATOM   1661 C CA  . ARG A 1 357 ? 99.498  156.285 141.729 1.00 81.71  ?  241 ARG E CA  1 
ATOM   1662 C C   . ARG A 1 357 ? 98.061  156.785 141.737 1.00 82.67  ?  241 ARG E C   1 
ATOM   1663 O O   . ARG A 1 357 ? 97.588  157.340 142.735 1.00 87.97  ?  241 ARG E O   1 
ATOM   1664 C CB  . ARG A 1 357 ? 100.357 157.161 140.816 1.00 83.80  ?  241 ARG E CB  1 
ATOM   1665 C CG  . ARG A 1 357 ? 101.829 157.220 141.177 1.00 83.80  ?  241 ARG E CG  1 
ATOM   1666 C CD  . ARG A 1 357 ? 102.071 158.195 142.315 1.00 84.58  ?  241 ARG E CD  1 
ATOM   1667 N NE  . ARG A 1 357 ? 101.875 157.558 143.610 1.00 86.04  ?  241 ARG E NE  1 
ATOM   1668 C CZ  . ARG A 1 357 ? 102.726 156.701 144.157 1.00 84.49  ?  241 ARG E CZ  1 
ATOM   1669 N NH1 . ARG A 1 357 ? 103.874 156.401 143.574 1.00 82.11  1  241 ARG E NH1 1 
ATOM   1670 N NH2 . ARG A 1 357 ? 102.417 156.133 145.317 1.00 83.47  ?  241 ARG E NH2 1 
ATOM   1671 N N   . MET A 1 358 ? 97.352  156.593 140.629 1.00 84.81  ?  242 MET E N   1 
ATOM   1672 C CA  . MET A 1 358 ? 95.924  156.862 140.536 1.00 87.45  ?  242 MET E CA  1 
ATOM   1673 C C   . MET A 1 358 ? 95.202  155.524 140.572 1.00 89.43  ?  242 MET E C   1 
ATOM   1674 O O   . MET A 1 358 ? 95.326  154.725 139.637 1.00 91.33  ?  242 MET E O   1 
ATOM   1675 C CB  . MET A 1 358 ? 95.586  157.629 139.259 1.00 85.98  ?  242 MET E CB  1 
ATOM   1676 N N   . HIS A 1 359 ? 94.446  155.284 141.640 1.00 99.22  ?  243 HIS E N   1 
ATOM   1677 C CA  . HIS A 1 359 ? 93.852  153.971 141.844 1.00 100.40 ?  243 HIS E CA  1 
ATOM   1678 C C   . HIS A 1 359 ? 92.716  153.736 140.858 1.00 101.65 ?  243 HIS E C   1 
ATOM   1679 O O   . HIS A 1 359 ? 91.550  154.014 141.154 1.00 102.18 ?  243 HIS E O   1 
ATOM   1680 C CB  . HIS A 1 359 ? 93.362  153.821 143.285 1.00 103.05 ?  243 HIS E CB  1 
ATOM   1681 C CG  . HIS A 1 359 ? 94.421  154.081 144.311 1.00 105.68 ?  243 HIS E CG  1 
ATOM   1682 N ND1 . HIS A 1 359 ? 95.515  153.258 144.475 1.00 102.74 ?  243 HIS E ND1 1 
ATOM   1683 C CD2 . HIS A 1 359 ? 94.553  155.069 145.227 1.00 102.63 ?  243 HIS E CD2 1 
ATOM   1684 C CE1 . HIS A 1 359 ? 96.275  153.729 145.447 1.00 100.10 ?  243 HIS E CE1 1 
ATOM   1685 N NE2 . HIS A 1 359 ? 95.714  154.827 145.920 1.00 101.47 ?  243 HIS E NE2 1 
ATOM   1686 N N   . LEU A 1 360 ? 93.061  153.222 139.681 1.00 109.38 ?  244 LEU E N   1 
ATOM   1687 C CA  . LEU A 1 360 ? 92.100  152.915 138.633 1.00 109.84 ?  244 LEU E CA  1 
ATOM   1688 C C   . LEU A 1 360 ? 91.745  151.436 138.695 1.00 110.62 ?  244 LEU E C   1 
ATOM   1689 O O   . LEU A 1 360 ? 92.635  150.580 138.749 1.00 108.53 ?  244 LEU E O   1 
ATOM   1690 C CB  . LEU A 1 360 ? 92.669  153.267 137.258 1.00 108.79 ?  244 LEU E CB  1 
ATOM   1691 C CG  . LEU A 1 360 ? 91.690  153.755 136.189 1.00 110.89 ?  244 LEU E CG  1 
ATOM   1692 C CD1 . LEU A 1 360 ? 90.955  155.000 136.659 1.00 111.63 ?  244 LEU E CD1 1 
ATOM   1693 C CD2 . LEU A 1 360 ? 92.434  154.028 134.893 1.00 108.55 ?  244 LEU E CD2 1 
ATOM   1694 N N   . ASN A 1 361 ? 90.448  151.141 138.683 1.00 111.27 ?  245 ASN E N   1 
ATOM   1695 C CA  . ASN A 1 361 ? 89.956  149.770 138.727 1.00 110.47 ?  245 ASN E CA  1 
ATOM   1696 C C   . ASN A 1 361 ? 89.960  149.105 137.359 1.00 112.28 ?  245 ASN E C   1 
ATOM   1697 O O   . ASN A 1 361 ? 89.218  148.137 137.156 1.00 115.48 ?  245 ASN E O   1 
ATOM   1698 C CB  . ASN A 1 361 ? 88.544  149.739 139.317 1.00 110.05 ?  245 ASN E CB  1 
ATOM   1699 C CG  . ASN A 1 361 ? 88.543  149.520 140.816 1.00 108.78 ?  245 ASN E CG  1 
ATOM   1700 O OD1 . ASN A 1 361 ? 89.333  148.735 141.340 1.00 107.78 ?  245 ASN E OD1 1 
ATOM   1701 N ND2 . ASN A 1 361 ? 87.654  150.215 141.515 1.00 110.84 ?  245 ASN E ND2 1 
ATOM   1702 N N   . LEU A 1 362 ? 90.749  149.637 136.422 1.00 106.80 ?  246 LEU E N   1 
ATOM   1703 C CA  . LEU A 1 362 ? 90.887  149.166 135.046 1.00 106.19 ?  246 LEU E CA  1 
ATOM   1704 C C   . LEU A 1 362 ? 89.640  149.492 134.231 1.00 106.39 ?  246 LEU E C   1 
ATOM   1705 O O   . LEU A 1 362 ? 89.654  149.364 133.002 1.00 101.51 ?  246 LEU E O   1 
ATOM   1706 C CB  . LEU A 1 362 ? 91.188  147.660 134.993 1.00 106.66 ?  246 LEU E CB  1 
ATOM   1707 C CG  . LEU A 1 362 ? 92.367  147.092 135.796 1.00 105.91 ?  246 LEU E CG  1 
ATOM   1708 C CD1 . LEU A 1 362 ? 91.909  146.388 137.067 1.00 101.94 ?  246 LEU E CD1 1 
ATOM   1709 C CD2 . LEU A 1 362 ? 93.191  146.146 134.937 1.00 106.26 ?  246 LEU E CD2 1 
ATOM   1710 N N   . GLU A 1 363 ? 88.580  149.943 134.913 1.00 114.94 ?  247 GLU E N   1 
ATOM   1711 C CA  . GLU A 1 363 ? 87.325  150.481 134.348 1.00 113.80 ?  247 GLU E CA  1 
ATOM   1712 C C   . GLU A 1 363 ? 86.952  149.692 133.091 1.00 114.24 ?  247 GLU E C   1 
ATOM   1713 O O   . GLU A 1 363 ? 87.037  148.456 133.103 1.00 113.22 ?  247 GLU E O   1 
ATOM   1714 C CB  . GLU A 1 363 ? 87.466  151.993 134.169 1.00 113.88 ?  247 GLU E CB  1 
ATOM   1715 C CG  . GLU A 1 363 ? 88.510  152.452 133.157 1.00 111.84 ?  247 GLU E CG  1 
ATOM   1716 C CD  . GLU A 1 363 ? 89.075  153.818 133.482 1.00 111.30 ?  247 GLU E CD  1 
ATOM   1717 O OE1 . GLU A 1 363 ? 88.560  154.469 134.413 1.00 109.94 ?  247 GLU E OE1 1 
ATOM   1718 O OE2 . GLU A 1 363 ? 90.025  154.247 132.796 1.00 110.24 -1 247 GLU E OE2 1 
ATOM   1719 N N   . VAL A 1 364 ? 86.524  150.346 132.013 1.00 121.02 ?  248 VAL E N   1 
ATOM   1720 C CA  . VAL A 1 364 ? 86.335  149.709 130.716 1.00 121.63 ?  248 VAL E CA  1 
ATOM   1721 C C   . VAL A 1 364 ? 87.173  150.488 129.712 1.00 119.91 ?  248 VAL E C   1 
ATOM   1722 O O   . VAL A 1 364 ? 87.299  150.101 128.544 1.00 117.27 ?  248 VAL E O   1 
ATOM   1723 C CB  . VAL A 1 364 ? 84.850  149.671 130.310 1.00 122.79 ?  248 VAL E CB  1 
ATOM   1724 C CG1 . VAL A 1 364 ? 84.388  151.046 129.848 1.00 120.39 ?  248 VAL E CG1 1 
ATOM   1725 C CG2 . VAL A 1 364 ? 84.610  148.622 129.231 1.00 119.50 ?  248 VAL E CG2 1 
ATOM   1726 N N   . LEU A 1 365 ? 87.745  151.602 130.168 1.00 121.96 ?  249 LEU E N   1 
ATOM   1727 C CA  . LEU A 1 365 ? 88.617  152.407 129.322 1.00 124.25 ?  249 LEU E CA  1 
ATOM   1728 C C   . LEU A 1 365 ? 90.061  151.926 129.369 1.00 123.22 ?  249 LEU E C   1 
ATOM   1729 O O   . LEU A 1 365 ? 90.817  152.160 128.421 1.00 121.07 ?  249 LEU E O   1 
ATOM   1730 C CB  . LEU A 1 365 ? 88.543  153.877 129.739 1.00 121.87 ?  249 LEU E CB  1 
ATOM   1731 C CG  . LEU A 1 365 ? 87.154  154.517 129.806 1.00 119.93 ?  249 LEU E CG  1 
ATOM   1732 C CD1 . LEU A 1 365 ? 87.265  156.019 130.010 1.00 119.59 ?  249 LEU E CD1 1 
ATOM   1733 C CD2 . LEU A 1 365 ? 86.349  154.204 128.555 1.00 120.00 ?  249 LEU E CD2 1 
ATOM   1734 N N   . TYR A 1 366 ? 90.462  151.260 130.453 1.00 118.24 ?  250 TYR E N   1 
ATOM   1735 C CA  . TYR A 1 366 ? 91.837  150.812 130.627 1.00 117.31 ?  250 TYR E CA  1 
ATOM   1736 C C   . TYR A 1 366 ? 91.963  149.292 130.575 1.00 117.62 ?  250 TYR E C   1 
ATOM   1737 O O   . TYR A 1 366 ? 92.912  148.723 131.120 1.00 116.72 ?  250 TYR E O   1 
ATOM   1738 C CB  . TYR A 1 366 ? 92.417  151.351 131.933 1.00 116.28 ?  250 TYR E CB  1 
ATOM   1739 C CG  . TYR A 1 366 ? 93.411  152.470 131.718 1.00 119.86 ?  250 TYR E CG  1 
ATOM   1740 C CD1 . TYR A 1 366 ? 93.040  153.632 131.053 1.00 119.12 ?  250 TYR E CD1 1 
ATOM   1741 C CD2 . TYR A 1 366 ? 94.720  152.360 132.166 1.00 118.39 ?  250 TYR E CD2 1 
ATOM   1742 C CE1 . TYR A 1 366 ? 93.942  154.658 130.849 1.00 116.24 ?  250 TYR E CE1 1 
ATOM   1743 C CE2 . TYR A 1 366 ? 95.630  153.382 131.965 1.00 117.39 ?  250 TYR E CE2 1 
ATOM   1744 C CZ  . TYR A 1 366 ? 95.235  154.527 131.305 1.00 116.03 ?  250 TYR E CZ  1 
ATOM   1745 O OH  . TYR A 1 366 ? 96.137  155.547 131.102 1.00 117.30 ?  250 TYR E OH  1 
ATOM   1746 N N   . CYS A 1 367 ? 91.012  148.620 129.929 1.00 114.97 ?  251 CYS E N   1 
ATOM   1747 C CA  . CYS A 1 367 ? 91.143  147.204 129.620 1.00 110.90 ?  251 CYS E CA  1 
ATOM   1748 C C   . CYS A 1 367 ? 91.640  146.976 128.200 1.00 111.35 ?  251 CYS E C   1 
ATOM   1749 O O   . CYS A 1 367 ? 91.710  145.827 127.753 1.00 112.08 ?  251 CYS E O   1 
ATOM   1750 C CB  . CYS A 1 367 ? 89.813  146.479 129.835 1.00 112.34 ?  251 CYS E CB  1 
ATOM   1751 S SG  . CYS A 1 367 ? 88.384  147.250 129.052 1.00 124.08 ?  251 CYS E SG  1 
ATOM   1752 N N   . HIS A 1 368 ? 91.980  148.045 127.481 1.00 88.12  ?  252 HIS E N   1 
ATOM   1753 C CA  . HIS A 1 368 ? 92.532  147.948 126.137 1.00 88.22  ?  252 HIS E CA  1 
ATOM   1754 C C   . HIS A 1 368 ? 93.994  148.353 126.052 1.00 85.90  ?  252 HIS E C   1 
ATOM   1755 O O   . HIS A 1 368 ? 94.681  147.937 125.118 1.00 84.98  ?  252 HIS E O   1 
ATOM   1756 C CB  . HIS A 1 368 ? 91.722  148.811 125.162 1.00 82.34  ?  252 HIS E CB  1 
ATOM   1757 N N   . VAL A 1 369 ? 94.483  149.155 126.998 1.00 75.93  ?  253 VAL E N   1 
ATOM   1758 C CA  . VAL A 1 369 ? 95.887  149.549 126.973 1.00 72.86  ?  253 VAL E CA  1 
ATOM   1759 C C   . VAL A 1 369 ? 96.728  148.636 127.860 1.00 72.62  ?  253 VAL E C   1 
ATOM   1760 O O   . VAL A 1 369 ? 97.932  148.476 127.626 1.00 70.46  ?  253 VAL E O   1 
ATOM   1761 C CB  . VAL A 1 369 ? 96.034  151.028 127.375 1.00 74.14  ?  253 VAL E CB  1 
ATOM   1762 C CG1 . VAL A 1 369 ? 95.740  151.219 128.854 1.00 75.55  ?  253 VAL E CG1 1 
ATOM   1763 C CG2 . VAL A 1 369 ? 97.422  151.544 127.025 1.00 76.74  ?  253 VAL E CG2 1 
ATOM   1764 N N   . TYR A 1 370 ? 96.123  148.023 128.881 1.00 70.71  ?  254 TYR E N   1 
ATOM   1765 C CA  . TYR A 1 370 ? 96.869  147.084 129.712 1.00 69.36  ?  254 TYR E CA  1 
ATOM   1766 C C   . TYR A 1 370 ? 97.326  145.882 128.899 1.00 77.33  ?  254 TYR E C   1 
ATOM   1767 O O   . TYR A 1 370 ? 98.451  145.399 129.072 1.00 85.64  ?  254 TYR E O   1 
ATOM   1768 C CB  . TYR A 1 370 ? 96.026  146.630 130.904 1.00 67.09  ?  254 TYR E CB  1 
ATOM   1769 C CG  . TYR A 1 370 ? 96.637  145.459 131.640 1.00 70.34  ?  254 TYR E CG  1 
ATOM   1770 C CD1 . TYR A 1 370 ? 97.918  145.538 132.160 1.00 70.05  ?  254 TYR E CD1 1 
ATOM   1771 C CD2 . TYR A 1 370 ? 95.942  144.271 131.800 1.00 72.23  ?  254 TYR E CD2 1 
ATOM   1772 C CE1 . TYR A 1 370 ? 98.488  144.476 132.824 1.00 66.67  ?  254 TYR E CE1 1 
ATOM   1773 C CE2 . TYR A 1 370 ? 96.506  143.200 132.464 1.00 70.70  ?  254 TYR E CE2 1 
ATOM   1774 C CZ  . TYR A 1 370 ? 97.779  143.310 132.974 1.00 68.12  ?  254 TYR E CZ  1 
ATOM   1775 O OH  . TYR A 1 370 ? 98.346  142.248 133.638 1.00 76.17  ?  254 TYR E OH  1 
ATOM   1776 N N   . LEU A 1 371 ? 96.463  145.379 128.014 1.00 70.38  ?  255 LEU E N   1 
ATOM   1777 C CA  . LEU A 1 371 ? 96.851  144.271 127.149 1.00 66.84  ?  255 LEU E CA  1 
ATOM   1778 C C   . LEU A 1 371 ? 98.018  144.662 126.253 1.00 78.36  ?  255 LEU E C   1 
ATOM   1779 O O   . LEU A 1 371 ? 98.959  143.880 126.064 1.00 76.11  ?  255 LEU E O   1 
ATOM   1780 C CB  . LEU A 1 371 ? 95.655  143.827 126.309 1.00 63.18  ?  255 LEU E CB  1 
ATOM   1781 C CG  . LEU A 1 371 ? 94.337  143.674 127.065 1.00 67.33  ?  255 LEU E CG  1 
ATOM   1782 C CD1 . LEU A 1 371 ? 93.212  143.293 126.119 1.00 71.53  ?  255 LEU E CD1 1 
ATOM   1783 C CD2 . LEU A 1 371 ? 94.482  142.643 128.168 1.00 75.31  ?  255 LEU E CD2 1 
ATOM   1784 N N   . VAL A 1 372 ? 97.975  145.875 125.697 1.00 85.46  ?  256 VAL E N   1 
ATOM   1785 C CA  . VAL A 1 372 ? 99.060  146.346 124.843 1.00 76.21  ?  256 VAL E CA  1 
ATOM   1786 C C   . VAL A 1 372 ? 100.360 146.423 125.629 1.00 76.75  ?  256 VAL E C   1 
ATOM   1787 O O   . VAL A 1 372 ? 101.412 145.983 125.155 1.00 85.77  ?  256 VAL E O   1 
ATOM   1788 C CB  . VAL A 1 372 ? 98.697  147.707 124.219 1.00 76.58  ?  256 VAL E CB  1 
ATOM   1789 C CG1 . VAL A 1 372 ? 99.889  148.283 123.471 1.00 77.55  ?  256 VAL E CG1 1 
ATOM   1790 C CG2 . VAL A 1 372 ? 97.498  147.568 123.297 1.00 78.50  ?  256 VAL E CG2 1 
ATOM   1791 N N   . CYS A 1 373 ? 100.310 146.980 126.842 1.00 64.61  ?  257 CYS E N   1 
ATOM   1792 C CA  . CYS A 1 373 ? 101.519 147.089 127.653 1.00 64.49  ?  257 CYS E CA  1 
ATOM   1793 C C   . CYS A 1 373 ? 102.070 145.715 128.016 1.00 68.34  ?  257 CYS E C   1 
ATOM   1794 O O   . CYS A 1 373 ? 103.288 145.491 127.968 1.00 72.54  ?  257 CYS E O   1 
ATOM   1795 C CB  . CYS A 1 373 ? 101.232 147.901 128.915 1.00 64.31  ?  257 CYS E CB  1 
ATOM   1796 S SG  . CYS A 1 373 ? 101.481 149.680 128.731 1.00 80.85  ?  257 CYS E SG  1 
ATOM   1797 N N   . MET A 1 374 ? 101.187 144.783 128.384 1.00 63.15  ?  258 MET E N   1 
ATOM   1798 C CA  . MET A 1 374 ? 101.631 143.441 128.740 1.00 64.46  ?  258 MET E CA  1 
ATOM   1799 C C   . MET A 1 374 ? 102.287 142.748 127.556 1.00 65.58  ?  258 MET E C   1 
ATOM   1800 O O   . MET A 1 374 ? 103.344 142.123 127.701 1.00 67.89  ?  258 MET E O   1 
ATOM   1801 C CB  . MET A 1 374 ? 100.451 142.618 129.257 1.00 67.16  ?  258 MET E CB  1 
ATOM   1802 N N   . SER A 1 375 ? 101.685 142.859 126.370 1.00 69.69  ?  259 SER E N   1 
ATOM   1803 C CA  . SER A 1 375 ? 102.273 142.228 125.194 1.00 71.63  ?  259 SER E CA  1 
ATOM   1804 C C   . SER A 1 375 ? 103.573 142.904 124.779 1.00 72.03  ?  259 SER E C   1 
ATOM   1805 O O   . SER A 1 375 ? 104.487 142.231 124.295 1.00 74.55  ?  259 SER E O   1 
ATOM   1806 C CB  . SER A 1 375 ? 101.271 142.226 124.045 1.00 70.73  ?  259 SER E CB  1 
ATOM   1807 O OG  . SER A 1 375 ? 99.972  141.960 124.533 1.00 73.20  ?  259 SER E OG  1 
ATOM   1808 N N   . LEU A 1 376 ? 103.678 144.223 124.953 1.00 68.94  ?  260 LEU E N   1 
ATOM   1809 C CA  . LEU A 1 376 ? 104.939 144.900 124.670 1.00 69.18  ?  260 LEU E CA  1 
ATOM   1810 C C   . LEU A 1 376 ? 106.042 144.406 125.595 1.00 70.02  ?  260 LEU E C   1 
ATOM   1811 O O   . LEU A 1 376 ? 107.165 144.144 125.150 1.00 67.79  ?  260 LEU E O   1 
ATOM   1812 C CB  . LEU A 1 376 ? 104.769 146.413 124.800 1.00 63.90  ?  260 LEU E CB  1 
ATOM   1813 C CG  . LEU A 1 376 ? 103.982 147.113 123.692 1.00 61.32  ?  260 LEU E CG  1 
ATOM   1814 C CD1 . LEU A 1 376 ? 103.856 148.598 123.985 1.00 61.56  ?  260 LEU E CD1 1 
ATOM   1815 C CD2 . LEU A 1 376 ? 104.630 146.880 122.339 1.00 66.07  ?  260 LEU E CD2 1 
ATOM   1816 N N   . SER A 1 377 ? 105.737 144.271 126.888 1.00 61.81  ?  261 SER E N   1 
ATOM   1817 C CA  . SER A 1 377 ? 106.725 143.737 127.821 1.00 55.44  ?  261 SER E CA  1 
ATOM   1818 C C   . SER A 1 377 ? 107.094 142.305 127.461 1.00 60.50  ?  261 SER E C   1 
ATOM   1819 O O   . SER A 1 377 ? 108.267 141.918 127.537 1.00 68.76  ?  261 SER E O   1 
ATOM   1820 C CB  . SER A 1 377 ? 106.193 143.810 129.250 1.00 61.69  ?  261 SER E CB  1 
ATOM   1821 O OG  . SER A 1 377 ? 104.803 143.546 129.283 1.00 68.09  ?  261 SER E OG  1 
ATOM   1822 N N   . SER A 1 378 ? 106.103 141.505 127.063 1.00 68.70  ?  262 SER E N   1 
ATOM   1823 C CA  . SER A 1 378 ? 106.375 140.127 126.670 1.00 68.66  ?  262 SER E CA  1 
ATOM   1824 C C   . SER A 1 378 ? 107.285 140.068 125.451 1.00 68.53  ?  262 SER E C   1 
ATOM   1825 O O   . SER A 1 378 ? 108.217 139.262 125.407 1.00 72.17  ?  262 SER E O   1 
ATOM   1826 C CB  . SER A 1 378 ? 105.064 139.392 126.392 1.00 69.55  ?  262 SER E CB  1 
ATOM   1827 O OG  . SER A 1 378 ? 105.310 138.069 125.955 1.00 76.50  ?  262 SER E OG  1 
ATOM   1828 N N   . LEU A 1 379 ? 107.031 140.916 124.453 1.00 66.37  ?  263 LEU E N   1 
ATOM   1829 C CA  . LEU A 1 379 ? 107.865 140.919 123.254 1.00 68.59  ?  263 LEU E CA  1 
ATOM   1830 C C   . LEU A 1 379 ? 109.271 141.415 123.563 1.00 68.98  ?  263 LEU E C   1 
ATOM   1831 O O   . LEU A 1 379 ? 110.250 140.906 123.004 1.00 67.35  ?  263 LEU E O   1 
ATOM   1832 C CB  . LEU A 1 379 ? 107.214 141.771 122.164 1.00 68.12  ?  263 LEU E CB  1 
ATOM   1833 C CG  . LEU A 1 379 ? 107.880 141.770 120.786 1.00 66.89  ?  263 LEU E CG  1 
ATOM   1834 C CD1 . LEU A 1 379 ? 106.834 141.601 119.697 1.00 67.54  ?  263 LEU E CD1 1 
ATOM   1835 C CD2 . LEU A 1 379 ? 108.678 143.045 120.567 1.00 71.06  ?  263 LEU E CD2 1 
ATOM   1836 N N   . ASN A 1 380 ? 109.392 142.413 124.442 1.00 65.12  ?  264 ASN E N   1 
ATOM   1837 C CA  . ASN A 1 380 ? 110.712 142.872 124.863 1.00 58.39  ?  264 ASN E CA  1 
ATOM   1838 C C   . ASN A 1 380 ? 111.482 141.751 125.540 1.00 53.42  ?  264 ASN E C   1 
ATOM   1839 O O   . ASN A 1 380 ? 112.656 141.514 125.237 1.00 55.09  ?  264 ASN E O   1 
ATOM   1840 C CB  . ASN A 1 380 ? 110.575 144.068 125.805 1.00 59.57  ?  264 ASN E CB  1 
ATOM   1841 C CG  . ASN A 1 380 ? 111.897 144.483 126.421 1.00 60.95  ?  264 ASN E CG  1 
ATOM   1842 O OD1 . ASN A 1 380 ? 112.960 144.298 125.828 1.00 61.81  ?  264 ASN E OD1 1 
ATOM   1843 N ND2 . ASN A 1 380 ? 111.837 145.048 127.620 1.00 59.88  ?  264 ASN E ND2 1 
ATOM   1844 N N   . SER A 1 381 ? 110.826 141.034 126.452 1.00 61.51  ?  265 SER E N   1 
ATOM   1845 C CA  . SER A 1 381 ? 111.486 139.930 127.136 1.00 62.40  ?  265 SER E CA  1 
ATOM   1846 C C   . SER A 1 381 ? 111.811 138.798 126.170 1.00 64.78  ?  265 SER E C   1 
ATOM   1847 O O   . SER A 1 381 ? 112.805 138.085 126.346 1.00 69.49  ?  265 SER E O   1 
ATOM   1848 C CB  . SER A 1 381 ? 110.602 139.437 128.278 1.00 60.91  ?  265 SER E CB  1 
ATOM   1849 O OG  . SER A 1 381 ? 110.692 140.298 129.397 1.00 63.56  ?  265 SER E OG  1 
ATOM   1850 N N   . SER A 1 382 ? 110.976 138.614 125.147 1.00 65.24  ?  266 SER E N   1 
ATOM   1851 C CA  . SER A 1 382 ? 111.201 137.560 124.165 1.00 65.36  ?  266 SER E CA  1 
ATOM   1852 C C   . SER A 1 382 ? 112.417 137.862 123.301 1.00 69.88  ?  266 SER E C   1 
ATOM   1853 O O   . SER A 1 382 ? 113.263 136.991 123.068 1.00 68.74  ?  266 SER E O   1 
ATOM   1854 C CB  . SER A 1 382 ? 109.952 137.395 123.299 1.00 63.10  ?  266 SER E CB  1 
ATOM   1855 O OG  . SER A 1 382 ? 109.880 136.101 122.733 1.00 67.55  ?  266 SER E OG  1 
ATOM   1856 N N   . ALA A 1 383 ? 112.517 139.096 122.808 1.00 70.04  ?  267 ALA E N   1 
ATOM   1857 C CA  . ALA A 1 383 ? 113.629 139.491 121.954 1.00 66.54  ?  267 ALA E CA  1 
ATOM   1858 C C   . ALA A 1 383 ? 114.884 139.841 122.738 1.00 65.72  ?  267 ALA E C   1 
ATOM   1859 O O   . ALA A 1 383 ? 115.945 140.007 122.129 1.00 71.63  ?  267 ALA E O   1 
ATOM   1860 C CB  . ALA A 1 383 ? 113.225 140.679 121.078 1.00 65.66  ?  267 ALA E CB  1 
ATOM   1861 N N   . ASN A 1 384 ? 114.786 139.962 124.061 1.00 62.89  ?  268 ASN E N   1 
ATOM   1862 C CA  . ASN A 1 384 ? 115.956 140.305 124.866 1.00 59.98  ?  268 ASN E CA  1 
ATOM   1863 C C   . ASN A 1 384 ? 117.095 139.302 124.728 1.00 63.73  ?  268 ASN E C   1 
ATOM   1864 O O   . ASN A 1 384 ? 118.245 139.737 124.547 1.00 68.25  ?  268 ASN E O   1 
ATOM   1865 C CB  . ASN A 1 384 ? 115.525 140.474 126.326 1.00 61.13  ?  268 ASN E CB  1 
ATOM   1866 C CG  . ASN A 1 384 ? 116.372 141.476 127.065 1.00 65.04  ?  268 ASN E CG  1 
ATOM   1867 O OD1 . ASN A 1 384 ? 117.107 142.250 126.456 1.00 65.02  ?  268 ASN E OD1 1 
ATOM   1868 N ND2 . ASN A 1 384 ? 116.267 141.479 128.388 1.00 63.71  ?  268 ASN E ND2 1 
ATOM   1869 N N   . PRO A 1 385 ? 116.878 137.984 124.817 1.00 63.93  ?  269 PRO E N   1 
ATOM   1870 C CA  . PRO A 1 385 ? 117.996 137.061 124.569 1.00 61.52  ?  269 PRO E CA  1 
ATOM   1871 C C   . PRO A 1 385 ? 118.564 137.171 123.169 1.00 64.55  ?  269 PRO E C   1 
ATOM   1872 O O   . PRO A 1 385 ? 119.774 136.990 122.988 1.00 65.40  ?  269 PRO E O   1 
ATOM   1873 C CB  . PRO A 1 385 ? 117.374 135.679 124.815 1.00 65.72  ?  269 PRO E CB  1 
ATOM   1874 C CG  . PRO A 1 385 ? 115.921 135.881 124.614 1.00 67.51  ?  269 PRO E CG  1 
ATOM   1875 C CD  . PRO A 1 385 ? 115.649 137.246 125.157 1.00 65.37  ?  269 PRO E CD  1 
ATOM   1876 N N   . ILE A 1 386 ? 117.723 137.468 122.175 1.00 66.30  ?  270 ILE E N   1 
ATOM   1877 C CA  . ILE A 1 386 ? 118.185 137.522 120.790 1.00 64.46  ?  270 ILE E CA  1 
ATOM   1878 C C   . ILE A 1 386 ? 119.292 138.556 120.644 1.00 60.48  ?  270 ILE E C   1 
ATOM   1879 O O   . ILE A 1 386 ? 120.433 138.218 120.316 1.00 61.74  ?  270 ILE E O   1 
ATOM   1880 C CB  . ILE A 1 386 ? 117.014 137.816 119.837 1.00 62.71  ?  270 ILE E CB  1 
ATOM   1881 C CG1 . ILE A 1 386 ? 116.153 136.568 119.648 1.00 65.26  ?  270 ILE E CG1 1 
ATOM   1882 C CG2 . ILE A 1 386 ? 117.531 138.292 118.489 1.00 57.54  ?  270 ILE E CG2 1 
ATOM   1883 C CD1 . ILE A 1 386 ? 114.965 136.780 118.734 1.00 62.36  ?  270 ILE E CD1 1 
ATOM   1884 N N   . ILE A 1 387 ? 118.984 139.816 120.965 1.00 55.48  ?  271 ILE E N   1 
ATOM   1885 C CA  . ILE A 1 387 ? 119.913 140.913 120.708 1.00 62.06  ?  271 ILE E CA  1 
ATOM   1886 C C   . ILE A 1 387 ? 121.235 140.684 121.427 1.00 63.21  ?  271 ILE E C   1 
ATOM   1887 O O   . ILE A 1 387 ? 122.310 140.968 120.885 1.00 65.57  ?  271 ILE E O   1 
ATOM   1888 C CB  . ILE A 1 387 ? 119.277 142.254 121.120 1.00 55.42  ?  271 ILE E CB  1 
ATOM   1889 C CG1 . ILE A 1 387 ? 118.029 142.535 120.286 1.00 54.43  ?  271 ILE E CG1 1 
ATOM   1890 C CG2 . ILE A 1 387 ? 120.274 143.390 120.973 1.00 58.12  ?  271 ILE E CG2 1 
ATOM   1891 C CD1 . ILE A 1 387 ? 116.824 142.913 121.110 1.00 57.77  ?  271 ILE E CD1 1 
ATOM   1892 N N   . TYR A 1 388 ? 121.183 140.159 122.647 1.00 54.13  ?  272 TYR E N   1 
ATOM   1893 C CA  . TYR A 1 388 ? 122.381 140.073 123.467 1.00 57.02  ?  272 TYR E CA  1 
ATOM   1894 C C   . TYR A 1 388 ? 123.172 138.786 123.277 1.00 64.50  ?  272 TYR E C   1 
ATOM   1895 O O   . TYR A 1 388 ? 124.351 138.751 123.645 1.00 68.07  ?  272 TYR E O   1 
ATOM   1896 C CB  . TYR A 1 388 ? 122.015 140.244 124.944 1.00 55.31  ?  272 TYR E CB  1 
ATOM   1897 C CG  . TYR A 1 388 ? 121.598 141.656 125.284 1.00 59.93  ?  272 TYR E CG  1 
ATOM   1898 C CD1 . TYR A 1 388 ? 122.545 142.655 125.459 1.00 63.99  ?  272 TYR E CD1 1 
ATOM   1899 C CD2 . TYR A 1 388 ? 120.259 141.993 125.418 1.00 56.06  ?  272 TYR E CD2 1 
ATOM   1900 C CE1 . TYR A 1 388 ? 122.171 143.948 125.763 1.00 59.18  ?  272 TYR E CE1 1 
ATOM   1901 C CE2 . TYR A 1 388 ? 119.877 143.284 125.722 1.00 54.72  ?  272 TYR E CE2 1 
ATOM   1902 C CZ  . TYR A 1 388 ? 120.836 144.256 125.893 1.00 55.64  ?  272 TYR E CZ  1 
ATOM   1903 O OH  . TYR A 1 388 ? 120.459 145.543 126.198 1.00 60.00  ?  272 TYR E OH  1 
ATOM   1904 N N   . PHE A 1 389 ? 122.578 137.732 122.723 1.00 63.54  ?  273 PHE E N   1 
ATOM   1905 C CA  . PHE A 1 389 ? 123.397 136.539 122.536 1.00 64.52  ?  273 PHE E CA  1 
ATOM   1906 C C   . PHE A 1 389 ? 123.384 135.999 121.114 1.00 66.95  ?  273 PHE E C   1 
ATOM   1907 O O   . PHE A 1 389 ? 124.439 135.619 120.600 1.00 67.21  ?  273 PHE E O   1 
ATOM   1908 C CB  . PHE A 1 389 ? 122.933 135.444 123.504 1.00 57.78  ?  273 PHE E CB  1 
ATOM   1909 C CG  . PHE A 1 389 ? 123.878 134.283 123.605 1.00 62.00  ?  273 PHE E CG  1 
ATOM   1910 C CD1 . PHE A 1 389 ? 125.016 134.366 124.387 1.00 65.27  ?  273 PHE E CD1 1 
ATOM   1911 C CD2 . PHE A 1 389 ? 123.624 133.107 122.921 1.00 65.79  ?  273 PHE E CD2 1 
ATOM   1912 C CE1 . PHE A 1 389 ? 125.885 133.297 124.484 1.00 68.81  ?  273 PHE E CE1 1 
ATOM   1913 C CE2 . PHE A 1 389 ? 124.489 132.036 123.013 1.00 66.15  ?  273 PHE E CE2 1 
ATOM   1914 C CZ  . PHE A 1 389 ? 125.621 132.131 123.796 1.00 68.83  ?  273 PHE E CZ  1 
ATOM   1915 N N   . PHE A 1 390 ? 122.222 135.967 120.460 1.00 63.29  ?  274 PHE E N   1 
ATOM   1916 C CA  . PHE A 1 390 ? 122.121 135.305 119.168 1.00 58.16  ?  274 PHE E CA  1 
ATOM   1917 C C   . PHE A 1 390 ? 122.742 136.136 118.058 1.00 63.46  ?  274 PHE E C   1 
ATOM   1918 O O   . PHE A 1 390 ? 123.277 135.574 117.098 1.00 71.19  ?  274 PHE E O   1 
ATOM   1919 C CB  . PHE A 1 390 ? 120.658 135.004 118.846 1.00 63.06  ?  274 PHE E CB  1 
ATOM   1920 C CG  . PHE A 1 390 ? 120.054 133.945 119.721 1.00 65.75  ?  274 PHE E CG  1 
ATOM   1921 C CD1 . PHE A 1 390 ? 120.858 133.018 120.363 1.00 64.88  ?  274 PHE E CD1 1 
ATOM   1922 C CD2 . PHE A 1 390 ? 118.685 133.879 119.906 1.00 63.07  ?  274 PHE E CD2 1 
ATOM   1923 C CE1 . PHE A 1 390 ? 120.306 132.044 121.170 1.00 63.56  ?  274 PHE E CE1 1 
ATOM   1924 C CE2 . PHE A 1 390 ? 118.128 132.907 120.712 1.00 62.66  ?  274 PHE E CE2 1 
ATOM   1925 C CZ  . PHE A 1 390 ? 118.940 131.989 121.345 1.00 64.04  ?  274 PHE E CZ  1 
ATOM   1926 N N   . VAL A 1 391 ? 122.679 137.463 118.169 1.00 63.86  ?  275 VAL E N   1 
ATOM   1927 C CA  . VAL A 1 391 ? 123.347 138.318 117.194 1.00 64.25  ?  275 VAL E CA  1 
ATOM   1928 C C   . VAL A 1 391 ? 124.850 138.080 117.230 1.00 63.94  ?  275 VAL E C   1 
ATOM   1929 O O   . VAL A 1 391 ? 125.500 137.950 116.185 1.00 66.24  ?  275 VAL E O   1 
ATOM   1930 C CB  . VAL A 1 391 ? 122.994 139.794 117.452 1.00 64.07  ?  275 VAL E CB  1 
ATOM   1931 C CG1 . VAL A 1 391 ? 124.087 140.710 116.925 1.00 67.21  ?  275 VAL E CG1 1 
ATOM   1932 C CG2 . VAL A 1 391 ? 121.654 140.134 116.820 1.00 63.89  ?  275 VAL E CG2 1 
ATOM   1933 N N   . GLY A 1 392 ? 125.423 138.004 118.432 1.00 66.72  ?  276 GLY E N   1 
ATOM   1934 C CA  . GLY A 1 392 ? 126.843 137.719 118.546 1.00 70.70  ?  276 GLY E CA  1 
ATOM   1935 C C   . GLY A 1 392 ? 127.203 136.320 118.081 1.00 72.10  ?  276 GLY E C   1 
ATOM   1936 O O   . GLY A 1 392 ? 128.211 136.126 117.395 1.00 72.04  ?  276 GLY E O   1 
ATOM   1937 N N   . SER A 1 393 ? 126.389 135.327 118.448 1.00 76.10  ?  277 SER E N   1 
ATOM   1938 C CA  . SER A 1 393 ? 126.682 133.950 118.060 1.00 76.79  ?  277 SER E CA  1 
ATOM   1939 C C   . SER A 1 393 ? 126.608 133.770 116.548 1.00 76.40  ?  277 SER E C   1 
ATOM   1940 O O   . SER A 1 393 ? 127.446 133.080 115.956 1.00 75.16  ?  277 SER E O   1 
ATOM   1941 C CB  . SER A 1 393 ? 125.721 132.991 118.762 1.00 73.01  ?  277 SER E CB  1 
ATOM   1942 N N   . PHE A 1 394 ? 125.616 134.387 115.904 1.00 77.30  ?  278 PHE E N   1 
ATOM   1943 C CA  . PHE A 1 394 ? 125.440 134.267 114.463 1.00 77.40  ?  278 PHE E CA  1 
ATOM   1944 C C   . PHE A 1 394 ? 126.337 135.210 113.674 1.00 81.61  ?  278 PHE E C   1 
ATOM   1945 O O   . PHE A 1 394 ? 126.317 135.166 112.440 1.00 81.61  ?  278 PHE E O   1 
ATOM   1946 C CB  . PHE A 1 394 ? 123.977 134.519 114.090 1.00 74.67  ?  278 PHE E CB  1 
ATOM   1947 N N   . ARG A 1 395 ? 127.111 136.064 114.349 1.00 81.66  ?  279 ARG E N   1 
ATOM   1948 C CA  . ARG A 1 395 ? 128.032 136.950 113.647 1.00 81.36  ?  279 ARG E CA  1 
ATOM   1949 C C   . ARG A 1 395 ? 129.179 136.191 112.992 1.00 78.82  ?  279 ARG E C   1 
ATOM   1950 O O   . ARG A 1 395 ? 129.806 136.718 112.067 1.00 74.31  ?  279 ARG E O   1 
ATOM   1951 C CB  . ARG A 1 395 ? 128.586 138.003 114.608 1.00 77.21  ?  279 ARG E CB  1 
ATOM   1952 N N   . GLN A 1 396 ? 129.466 134.976 113.447 1.00 76.61  ?  280 GLN E N   1 
ATOM   1953 C CA  . GLN A 1 396 ? 130.534 134.174 112.864 1.00 77.19  ?  280 GLN E CA  1 
ATOM   1954 C C   . GLN A 1 396 ? 130.105 132.718 112.717 1.00 79.11  ?  280 GLN E C   1 
ATOM   1955 O O   . GLN A 1 396 ? 128.975 132.430 112.322 1.00 76.48  ?  280 GLN E O   1 
ATOM   1956 C CB  . GLN A 1 396 ? 131.801 134.268 113.716 1.00 77.14  ?  280 GLN E CB  1 
HETATM 1957 C C1  . JW0 B 2 .   ? 95.670  144.211 135.671 1.00 103.79 ?  601 JW0 E C1  1 
HETATM 1958 C C2  . JW0 B 2 .   ? 94.792  144.272 136.918 1.00 106.33 ?  601 JW0 E C2  1 
HETATM 1959 C C3  . JW0 B 2 .   ? 95.104  145.568 137.697 1.00 106.67 ?  601 JW0 E C3  1 
HETATM 1960 O O3  . JW0 B 2 .   ? 106.629 150.107 140.577 1.00 104.53 ?  601 JW0 E O3  1 
HETATM 1961 C C4  . JW0 B 2 .   ? 96.595  145.823 137.975 1.00 108.18 ?  601 JW0 E C4  1 
HETATM 1962 C C5  . JW0 B 2 .   ? 97.478  145.538 136.776 1.00 107.28 ?  601 JW0 E C5  1 
HETATM 1963 O O5  . JW0 B 2 .   ? 94.119  141.761 135.704 1.00 106.79 ?  601 JW0 E O5  1 
HETATM 1964 C C6  . JW0 B 2 .   ? 97.148  144.233 136.193 1.00 104.09 ?  601 JW0 E C6  1 
HETATM 1965 C C10 . JW0 B 2 .   ? 99.017  145.474 137.158 1.00 107.13 ?  601 JW0 E C10 1 
HETATM 1966 C C11 . JW0 B 2 .   ? 100.640 145.485 138.762 1.00 107.35 ?  601 JW0 E C11 1 
HETATM 1967 C C12 . JW0 B 2 .   ? 101.449 146.569 138.113 1.00 108.87 ?  601 JW0 E C12 1 
HETATM 1968 C C13 . JW0 B 2 .   ? 101.236 146.592 136.596 1.00 106.91 ?  601 JW0 E C13 1 
HETATM 1969 C C14 . JW0 B 2 .   ? 99.756  146.348 136.246 1.00 105.89 ?  601 JW0 E C14 1 
HETATM 1970 C C15 . JW0 B 2 .   ? 101.081 145.611 140.240 1.00 105.82 ?  601 JW0 E C15 1 
HETATM 1971 C C16 . JW0 B 2 .   ? 102.569 146.185 140.041 1.00 107.05 ?  601 JW0 E C16 1 
HETATM 1972 C C17 . JW0 B 2 .   ? 102.795 146.186 138.528 1.00 107.35 ?  601 JW0 E C17 1 
HETATM 1973 C C18 . JW0 B 2 .   ? 103.815 147.254 138.099 1.00 107.50 ?  601 JW0 E C18 1 
HETATM 1974 C C19 . JW0 B 2 .   ? 104.446 147.853 139.343 1.00 106.23 ?  601 JW0 E C19 1 
HETATM 1975 C C20 . JW0 B 2 .   ? 105.779 148.529 139.007 1.00 105.46 ?  601 JW0 E C20 1 
HETATM 1976 C C21 . JW0 B 2 .   ? 104.885 146.578 137.246 1.00 107.28 ?  601 JW0 E C21 1 
HETATM 1977 C C22 . JW0 B 2 .   ? 101.000 147.833 138.865 1.00 106.60 ?  601 JW0 E C22 1 
HETATM 1978 C C23 . JW0 B 2 .   ? 97.301  146.644 135.717 1.00 107.49 ?  601 JW0 E C23 1 
HETATM 1979 C C24 . JW0 B 2 .   ? 105.786 149.872 139.699 1.00 105.23 ?  601 JW0 E C24 1 
HETATM 1980 C C7  . JW0 B 2 .   ? 97.018  144.929 139.137 1.00 106.35 ?  601 JW0 E C7  1 
HETATM 1981 C C8  . JW0 B 2 .   ? 98.367  145.273 139.621 1.00 105.75 ?  601 JW0 E C8  1 
HETATM 1982 C C9  . JW0 B 2 .   ? 99.247  145.949 138.551 1.00 107.69 ?  601 JW0 E C9  1 
HETATM 1983 O O1  . JW0 B 2 .   ? 101.949 145.541 136.115 1.00 107.86 ?  601 JW0 E O1  1 
HETATM 1984 O O2  . JW0 B 2 .   ? 104.924 150.737 139.388 1.00 106.90 ?  601 JW0 E O2  1 
HETATM 1985 O O4  . JW0 B 2 .   ? 95.130  143.160 137.667 1.00 108.86 ?  601 JW0 E O4  1 
HETATM 1986 O O6  . JW0 B 2 .   ? 93.388  141.264 137.953 1.00 109.25 -1 601 JW0 E O6  1 
HETATM 1987 O O7  . JW0 B 2 .   ? 95.729  140.667 137.230 1.00 106.79 ?  601 JW0 E O7  1 
HETATM 1988 P P1  . JW0 B 2 .   ? 94.588  141.658 137.128 1.00 115.09 ?  601 JW0 E P1  1 
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