data_9K8M
# 
_entry.id   9K8M 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9K8M         pdb_00009k8m 10.2210/pdb9k8m/pdb 
WWPDB D_1300052963 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-06 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9K8M 
_pdbx_database_status.recvd_initial_deposition_date   2024-10-24 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              tostars@mail.ru 
_pdbx_contact_author.name_first         Vladimir 
_pdbx_contact_author.name_last          Timofeev 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-5622-0470 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Timofeev, V.I.'   1 ? 
'Shevtsov, M.B.'   2 ? 
'Abramchik, Y.A.'  3 ? 
'Kostromina, M.A.' 4 ? 
'Zayats, E.A.'     5 ? 
'Kuranova, I.P.'   6 ? 
'Esipov, R.S.'     7 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Hypoxanthine-guanine phosphoribosyltransferase from E. coli with HEPES' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Timofeev, V.I.'   1 ? 
primary 'Shevtsov, M.B.'   2 ? 
primary 'Abramchik, Y.A.'  3 ? 
primary 'Kostromina, M.A.' 4 ? 
primary 'Zayats, E.A.'     5 ? 
primary 'Kuranova, I.P.'   6 ? 
primary 'Esipov, R.S.'     7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Hypoxanthine phosphoribosyltransferase'              19897.047 2  2.4.2.8 ? ? ? 
2 non-polymer syn '4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID' 238.305   2  ?       ? ? ? 
3 water       nat water                                                 18.015    39 ?       ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        HPRT 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MKHTVEVMIPEAEIKARIAELGRQITERYKDSGSDMVLVGLLRGSFMFMADLCREVQVSHEVDFMTASSYGSGMSTTRDV
KILKDLDEDIRGKDVLIVEDIIDSGNTLSKVREILSLREPKSLAICTLLDKPSRREVNVPVEFIGFSIPDEFVVGYGIDY
AQRYRHLPYIGKVILL
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MKHTVEVMIPEAEIKARIAELGRQITERYKDSGSDMVLVGLLRGSFMFMADLCREVQVSHEVDFMTASSYGSGMSTTRDV
KILKDLDEDIRGKDVLIVEDIIDSGNTLSKVREILSLREPKSLAICTLLDKPSRREVNVPVEFIGFSIPDEFVVGYGIDY
AQRYRHLPYIGKVILL
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 '4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID' EPE 
3 water                                                 HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   LYS n 
1 3   HIS n 
1 4   THR n 
1 5   VAL n 
1 6   GLU n 
1 7   VAL n 
1 8   MET n 
1 9   ILE n 
1 10  PRO n 
1 11  GLU n 
1 12  ALA n 
1 13  GLU n 
1 14  ILE n 
1 15  LYS n 
1 16  ALA n 
1 17  ARG n 
1 18  ILE n 
1 19  ALA n 
1 20  GLU n 
1 21  LEU n 
1 22  GLY n 
1 23  ARG n 
1 24  GLN n 
1 25  ILE n 
1 26  THR n 
1 27  GLU n 
1 28  ARG n 
1 29  TYR n 
1 30  LYS n 
1 31  ASP n 
1 32  SER n 
1 33  GLY n 
1 34  SER n 
1 35  ASP n 
1 36  MET n 
1 37  VAL n 
1 38  LEU n 
1 39  VAL n 
1 40  GLY n 
1 41  LEU n 
1 42  LEU n 
1 43  ARG n 
1 44  GLY n 
1 45  SER n 
1 46  PHE n 
1 47  MET n 
1 48  PHE n 
1 49  MET n 
1 50  ALA n 
1 51  ASP n 
1 52  LEU n 
1 53  CYS n 
1 54  ARG n 
1 55  GLU n 
1 56  VAL n 
1 57  GLN n 
1 58  VAL n 
1 59  SER n 
1 60  HIS n 
1 61  GLU n 
1 62  VAL n 
1 63  ASP n 
1 64  PHE n 
1 65  MET n 
1 66  THR n 
1 67  ALA n 
1 68  SER n 
1 69  SER n 
1 70  TYR n 
1 71  GLY n 
1 72  SER n 
1 73  GLY n 
1 74  MET n 
1 75  SER n 
1 76  THR n 
1 77  THR n 
1 78  ARG n 
1 79  ASP n 
1 80  VAL n 
1 81  LYS n 
1 82  ILE n 
1 83  LEU n 
1 84  LYS n 
1 85  ASP n 
1 86  LEU n 
1 87  ASP n 
1 88  GLU n 
1 89  ASP n 
1 90  ILE n 
1 91  ARG n 
1 92  GLY n 
1 93  LYS n 
1 94  ASP n 
1 95  VAL n 
1 96  LEU n 
1 97  ILE n 
1 98  VAL n 
1 99  GLU n 
1 100 ASP n 
1 101 ILE n 
1 102 ILE n 
1 103 ASP n 
1 104 SER n 
1 105 GLY n 
1 106 ASN n 
1 107 THR n 
1 108 LEU n 
1 109 SER n 
1 110 LYS n 
1 111 VAL n 
1 112 ARG n 
1 113 GLU n 
1 114 ILE n 
1 115 LEU n 
1 116 SER n 
1 117 LEU n 
1 118 ARG n 
1 119 GLU n 
1 120 PRO n 
1 121 LYS n 
1 122 SER n 
1 123 LEU n 
1 124 ALA n 
1 125 ILE n 
1 126 CYS n 
1 127 THR n 
1 128 LEU n 
1 129 LEU n 
1 130 ASP n 
1 131 LYS n 
1 132 PRO n 
1 133 SER n 
1 134 ARG n 
1 135 ARG n 
1 136 GLU n 
1 137 VAL n 
1 138 ASN n 
1 139 VAL n 
1 140 PRO n 
1 141 VAL n 
1 142 GLU n 
1 143 PHE n 
1 144 ILE n 
1 145 GLY n 
1 146 PHE n 
1 147 SER n 
1 148 ILE n 
1 149 PRO n 
1 150 ASP n 
1 151 GLU n 
1 152 PHE n 
1 153 VAL n 
1 154 VAL n 
1 155 GLY n 
1 156 TYR n 
1 157 GLY n 
1 158 ILE n 
1 159 ASP n 
1 160 TYR n 
1 161 ALA n 
1 162 GLN n 
1 163 ARG n 
1 164 TYR n 
1 165 ARG n 
1 166 HIS n 
1 167 LEU n 
1 168 PRO n 
1 169 TYR n 
1 170 ILE n 
1 171 GLY n 
1 172 LYS n 
1 173 VAL n 
1 174 ILE n 
1 175 LEU n 
1 176 LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   176 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'hpt, c0154' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     562 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                               ?     'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                              ?     'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                            ?     'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                       ?     'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                                              ?     'C3 H7 N O2 S'   121.158 
EPE non-polymer         . '4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID' HEPES 'C8 H18 N2 O4 S' 238.305 
GLN 'L-peptide linking' y GLUTAMINE                                             ?     'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                       ?     'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                               ?     'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                             ?     'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                                 ?     'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                            ?     'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                               ?     'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                                ?     'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                                            ?     'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE                                         ?     'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                                               ?     'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                                ?     'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                             ?     'C4 H9 N O3'     119.119 
TYR 'L-peptide linking' y TYROSINE                                              ?     'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                                ?     'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   5   5   MET MET A . n 
A 1 2   LYS 2   6   6   LYS LYS A . n 
A 1 3   HIS 3   7   7   HIS HIS A . n 
A 1 4   THR 4   8   8   THR THR A . n 
A 1 5   VAL 5   9   9   VAL VAL A . n 
A 1 6   GLU 6   10  10  GLU GLU A . n 
A 1 7   VAL 7   11  11  VAL VAL A . n 
A 1 8   MET 8   12  12  MET MET A . n 
A 1 9   ILE 9   13  13  ILE ILE A . n 
A 1 10  PRO 10  14  14  PRO PRO A . n 
A 1 11  GLU 11  15  15  GLU GLU A . n 
A 1 12  ALA 12  16  16  ALA ALA A . n 
A 1 13  GLU 13  17  17  GLU GLU A . n 
A 1 14  ILE 14  18  18  ILE ILE A . n 
A 1 15  LYS 15  19  19  LYS LYS A . n 
A 1 16  ALA 16  20  20  ALA ALA A . n 
A 1 17  ARG 17  21  21  ARG ARG A . n 
A 1 18  ILE 18  22  22  ILE ILE A . n 
A 1 19  ALA 19  23  23  ALA ALA A . n 
A 1 20  GLU 20  24  24  GLU GLU A . n 
A 1 21  LEU 21  25  25  LEU LEU A . n 
A 1 22  GLY 22  26  26  GLY GLY A . n 
A 1 23  ARG 23  27  27  ARG ARG A . n 
A 1 24  GLN 24  28  28  GLN GLN A . n 
A 1 25  ILE 25  29  29  ILE ILE A . n 
A 1 26  THR 26  30  30  THR THR A . n 
A 1 27  GLU 27  31  31  GLU GLU A . n 
A 1 28  ARG 28  32  32  ARG ARG A . n 
A 1 29  TYR 29  33  33  TYR TYR A . n 
A 1 30  LYS 30  34  34  LYS LYS A . n 
A 1 31  ASP 31  35  35  ASP ASP A . n 
A 1 32  SER 32  36  36  SER SER A . n 
A 1 33  GLY 33  37  37  GLY GLY A . n 
A 1 34  SER 34  38  38  SER SER A . n 
A 1 35  ASP 35  39  39  ASP ASP A . n 
A 1 36  MET 36  40  40  MET MET A . n 
A 1 37  VAL 37  41  41  VAL VAL A . n 
A 1 38  LEU 38  42  42  LEU LEU A . n 
A 1 39  VAL 39  43  43  VAL VAL A . n 
A 1 40  GLY 40  44  44  GLY GLY A . n 
A 1 41  LEU 41  45  45  LEU LEU A . n 
A 1 42  LEU 42  46  46  LEU LEU A . n 
A 1 43  ARG 43  47  47  ARG ARG A . n 
A 1 44  GLY 44  48  48  GLY GLY A . n 
A 1 45  SER 45  49  49  SER SER A . n 
A 1 46  PHE 46  50  50  PHE PHE A . n 
A 1 47  MET 47  51  51  MET MET A . n 
A 1 48  PHE 48  52  52  PHE PHE A . n 
A 1 49  MET 49  53  53  MET MET A . n 
A 1 50  ALA 50  54  54  ALA ALA A . n 
A 1 51  ASP 51  55  55  ASP ASP A . n 
A 1 52  LEU 52  56  56  LEU LEU A . n 
A 1 53  CYS 53  57  57  CYS CYS A . n 
A 1 54  ARG 54  58  58  ARG ARG A . n 
A 1 55  GLU 55  59  59  GLU GLU A . n 
A 1 56  VAL 56  60  60  VAL VAL A . n 
A 1 57  GLN 57  61  61  GLN GLN A . n 
A 1 58  VAL 58  62  62  VAL VAL A . n 
A 1 59  SER 59  63  63  SER SER A . n 
A 1 60  HIS 60  64  64  HIS HIS A . n 
A 1 61  GLU 61  65  65  GLU GLU A . n 
A 1 62  VAL 62  66  66  VAL VAL A . n 
A 1 63  ASP 63  67  67  ASP ASP A . n 
A 1 64  PHE 64  68  68  PHE PHE A . n 
A 1 65  MET 65  69  69  MET MET A . n 
A 1 66  THR 66  70  70  THR THR A . n 
A 1 67  ALA 67  71  71  ALA ALA A . n 
A 1 68  SER 68  72  72  SER SER A . n 
A 1 69  SER 69  73  73  SER SER A . n 
A 1 70  TYR 70  74  ?   ?   ?   A . n 
A 1 71  GLY 71  75  ?   ?   ?   A . n 
A 1 72  SER 72  76  ?   ?   ?   A . n 
A 1 73  GLY 73  77  ?   ?   ?   A . n 
A 1 74  MET 74  78  ?   ?   ?   A . n 
A 1 75  SER 75  79  ?   ?   ?   A . n 
A 1 76  THR 76  80  ?   ?   ?   A . n 
A 1 77  THR 77  81  81  THR THR A . n 
A 1 78  ARG 78  82  82  ARG ARG A . n 
A 1 79  ASP 79  83  83  ASP ASP A . n 
A 1 80  VAL 80  84  84  VAL VAL A . n 
A 1 81  LYS 81  85  85  LYS LYS A . n 
A 1 82  ILE 82  86  86  ILE ILE A . n 
A 1 83  LEU 83  87  87  LEU LEU A . n 
A 1 84  LYS 84  88  88  LYS LYS A . n 
A 1 85  ASP 85  89  89  ASP ASP A . n 
A 1 86  LEU 86  90  90  LEU LEU A . n 
A 1 87  ASP 87  91  91  ASP ASP A . n 
A 1 88  GLU 88  92  92  GLU GLU A . n 
A 1 89  ASP 89  93  93  ASP ASP A . n 
A 1 90  ILE 90  94  94  ILE ILE A . n 
A 1 91  ARG 91  95  95  ARG ARG A . n 
A 1 92  GLY 92  96  96  GLY GLY A . n 
A 1 93  LYS 93  97  97  LYS LYS A . n 
A 1 94  ASP 94  98  98  ASP ASP A . n 
A 1 95  VAL 95  99  99  VAL VAL A . n 
A 1 96  LEU 96  100 100 LEU LEU A . n 
A 1 97  ILE 97  101 101 ILE ILE A . n 
A 1 98  VAL 98  102 102 VAL VAL A . n 
A 1 99  GLU 99  103 103 GLU GLU A . n 
A 1 100 ASP 100 104 104 ASP ASP A . n 
A 1 101 ILE 101 105 105 ILE ILE A . n 
A 1 102 ILE 102 106 106 ILE ILE A . n 
A 1 103 ASP 103 107 107 ASP ASP A . n 
A 1 104 SER 104 108 108 SER SER A . n 
A 1 105 GLY 105 109 109 GLY GLY A . n 
A 1 106 ASN 106 110 110 ASN ASN A . n 
A 1 107 THR 107 111 111 THR THR A . n 
A 1 108 LEU 108 112 112 LEU LEU A . n 
A 1 109 SER 109 113 113 SER SER A . n 
A 1 110 LYS 110 114 114 LYS LYS A . n 
A 1 111 VAL 111 115 115 VAL VAL A . n 
A 1 112 ARG 112 116 116 ARG ARG A . n 
A 1 113 GLU 113 117 117 GLU GLU A . n 
A 1 114 ILE 114 118 118 ILE ILE A . n 
A 1 115 LEU 115 119 119 LEU LEU A . n 
A 1 116 SER 116 120 120 SER SER A . n 
A 1 117 LEU 117 121 121 LEU LEU A . n 
A 1 118 ARG 118 122 122 ARG ARG A . n 
A 1 119 GLU 119 123 123 GLU GLU A . n 
A 1 120 PRO 120 124 124 PRO PRO A . n 
A 1 121 LYS 121 125 125 LYS LYS A . n 
A 1 122 SER 122 126 126 SER SER A . n 
A 1 123 LEU 123 127 127 LEU LEU A . n 
A 1 124 ALA 124 128 128 ALA ALA A . n 
A 1 125 ILE 125 129 129 ILE ILE A . n 
A 1 126 CYS 126 130 130 CYS CYS A . n 
A 1 127 THR 127 131 131 THR THR A . n 
A 1 128 LEU 128 132 132 LEU LEU A . n 
A 1 129 LEU 129 133 133 LEU LEU A . n 
A 1 130 ASP 130 134 134 ASP ASP A . n 
A 1 131 LYS 131 135 135 LYS LYS A . n 
A 1 132 PRO 132 136 136 PRO PRO A . n 
A 1 133 SER 133 137 137 SER SER A . n 
A 1 134 ARG 134 138 138 ARG ARG A . n 
A 1 135 ARG 135 139 139 ARG ARG A . n 
A 1 136 GLU 136 140 140 GLU GLU A . n 
A 1 137 VAL 137 141 141 VAL VAL A . n 
A 1 138 ASN 138 142 142 ASN ASN A . n 
A 1 139 VAL 139 143 143 VAL VAL A . n 
A 1 140 PRO 140 144 144 PRO PRO A . n 
A 1 141 VAL 141 145 145 VAL VAL A . n 
A 1 142 GLU 142 146 146 GLU GLU A . n 
A 1 143 PHE 143 147 147 PHE PHE A . n 
A 1 144 ILE 144 148 148 ILE ILE A . n 
A 1 145 GLY 145 149 149 GLY GLY A . n 
A 1 146 PHE 146 150 150 PHE PHE A . n 
A 1 147 SER 147 151 151 SER SER A . n 
A 1 148 ILE 148 152 152 ILE ILE A . n 
A 1 149 PRO 149 153 153 PRO PRO A . n 
A 1 150 ASP 150 154 154 ASP ASP A . n 
A 1 151 GLU 151 155 155 GLU GLU A . n 
A 1 152 PHE 152 156 156 PHE PHE A . n 
A 1 153 VAL 153 157 157 VAL VAL A . n 
A 1 154 VAL 154 158 158 VAL VAL A . n 
A 1 155 GLY 155 159 159 GLY GLY A . n 
A 1 156 TYR 156 160 160 TYR TYR A . n 
A 1 157 GLY 157 161 161 GLY GLY A . n 
A 1 158 ILE 158 162 162 ILE ILE A . n 
A 1 159 ASP 159 163 163 ASP ASP A . n 
A 1 160 TYR 160 164 164 TYR TYR A . n 
A 1 161 ALA 161 165 165 ALA ALA A . n 
A 1 162 GLN 162 166 166 GLN GLN A . n 
A 1 163 ARG 163 167 167 ARG ARG A . n 
A 1 164 TYR 164 168 168 TYR TYR A . n 
A 1 165 ARG 165 169 169 ARG ARG A . n 
A 1 166 HIS 166 170 170 HIS HIS A . n 
A 1 167 LEU 167 171 171 LEU LEU A . n 
A 1 168 PRO 168 172 172 PRO PRO A . n 
A 1 169 TYR 169 173 173 TYR TYR A . n 
A 1 170 ILE 170 174 174 ILE ILE A . n 
A 1 171 GLY 171 175 175 GLY GLY A . n 
A 1 172 LYS 172 176 176 LYS LYS A . n 
A 1 173 VAL 173 177 177 VAL VAL A . n 
A 1 174 ILE 174 178 178 ILE ILE A . n 
A 1 175 LEU 175 179 179 LEU LEU A . n 
A 1 176 LEU 176 180 180 LEU LEU A . n 
B 1 1   MET 1   5   ?   ?   ?   B . n 
B 1 2   LYS 2   6   6   LYS LYS B . n 
B 1 3   HIS 3   7   7   HIS HIS B . n 
B 1 4   THR 4   8   8   THR THR B . n 
B 1 5   VAL 5   9   9   VAL VAL B . n 
B 1 6   GLU 6   10  10  GLU GLU B . n 
B 1 7   VAL 7   11  11  VAL VAL B . n 
B 1 8   MET 8   12  12  MET MET B . n 
B 1 9   ILE 9   13  13  ILE ILE B . n 
B 1 10  PRO 10  14  14  PRO PRO B . n 
B 1 11  GLU 11  15  15  GLU GLU B . n 
B 1 12  ALA 12  16  16  ALA ALA B . n 
B 1 13  GLU 13  17  17  GLU GLU B . n 
B 1 14  ILE 14  18  18  ILE ILE B . n 
B 1 15  LYS 15  19  19  LYS LYS B . n 
B 1 16  ALA 16  20  20  ALA ALA B . n 
B 1 17  ARG 17  21  21  ARG ARG B . n 
B 1 18  ILE 18  22  22  ILE ILE B . n 
B 1 19  ALA 19  23  23  ALA ALA B . n 
B 1 20  GLU 20  24  24  GLU GLU B . n 
B 1 21  LEU 21  25  25  LEU LEU B . n 
B 1 22  GLY 22  26  26  GLY GLY B . n 
B 1 23  ARG 23  27  27  ARG ARG B . n 
B 1 24  GLN 24  28  28  GLN GLN B . n 
B 1 25  ILE 25  29  29  ILE ILE B . n 
B 1 26  THR 26  30  30  THR THR B . n 
B 1 27  GLU 27  31  31  GLU GLU B . n 
B 1 28  ARG 28  32  32  ARG ARG B . n 
B 1 29  TYR 29  33  33  TYR TYR B . n 
B 1 30  LYS 30  34  34  LYS LYS B . n 
B 1 31  ASP 31  35  35  ASP ASP B . n 
B 1 32  SER 32  36  36  SER SER B . n 
B 1 33  GLY 33  37  37  GLY GLY B . n 
B 1 34  SER 34  38  38  SER SER B . n 
B 1 35  ASP 35  39  39  ASP ASP B . n 
B 1 36  MET 36  40  40  MET MET B . n 
B 1 37  VAL 37  41  41  VAL VAL B . n 
B 1 38  LEU 38  42  42  LEU LEU B . n 
B 1 39  VAL 39  43  43  VAL VAL B . n 
B 1 40  GLY 40  44  44  GLY GLY B . n 
B 1 41  LEU 41  45  45  LEU LEU B . n 
B 1 42  LEU 42  46  46  LEU LEU B . n 
B 1 43  ARG 43  47  47  ARG ARG B . n 
B 1 44  GLY 44  48  48  GLY GLY B . n 
B 1 45  SER 45  49  49  SER SER B . n 
B 1 46  PHE 46  50  50  PHE PHE B . n 
B 1 47  MET 47  51  51  MET MET B . n 
B 1 48  PHE 48  52  52  PHE PHE B . n 
B 1 49  MET 49  53  53  MET MET B . n 
B 1 50  ALA 50  54  54  ALA ALA B . n 
B 1 51  ASP 51  55  55  ASP ASP B . n 
B 1 52  LEU 52  56  56  LEU LEU B . n 
B 1 53  CYS 53  57  57  CYS CYS B . n 
B 1 54  ARG 54  58  58  ARG ARG B . n 
B 1 55  GLU 55  59  59  GLU GLU B . n 
B 1 56  VAL 56  60  60  VAL VAL B . n 
B 1 57  GLN 57  61  61  GLN GLN B . n 
B 1 58  VAL 58  62  62  VAL VAL B . n 
B 1 59  SER 59  63  63  SER SER B . n 
B 1 60  HIS 60  64  64  HIS HIS B . n 
B 1 61  GLU 61  65  65  GLU GLU B . n 
B 1 62  VAL 62  66  66  VAL VAL B . n 
B 1 63  ASP 63  67  67  ASP ASP B . n 
B 1 64  PHE 64  68  68  PHE PHE B . n 
B 1 65  MET 65  69  69  MET MET B . n 
B 1 66  THR 66  70  70  THR THR B . n 
B 1 67  ALA 67  71  71  ALA ALA B . n 
B 1 68  SER 68  72  72  SER SER B . n 
B 1 69  SER 69  73  ?   ?   ?   B . n 
B 1 70  TYR 70  74  ?   ?   ?   B . n 
B 1 71  GLY 71  75  ?   ?   ?   B . n 
B 1 72  SER 72  76  ?   ?   ?   B . n 
B 1 73  GLY 73  77  ?   ?   ?   B . n 
B 1 74  MET 74  78  ?   ?   ?   B . n 
B 1 75  SER 75  79  ?   ?   ?   B . n 
B 1 76  THR 76  80  ?   ?   ?   B . n 
B 1 77  THR 77  81  81  THR THR B . n 
B 1 78  ARG 78  82  82  ARG ARG B . n 
B 1 79  ASP 79  83  83  ASP ASP B . n 
B 1 80  VAL 80  84  84  VAL VAL B . n 
B 1 81  LYS 81  85  85  LYS LYS B . n 
B 1 82  ILE 82  86  86  ILE ILE B . n 
B 1 83  LEU 83  87  87  LEU LEU B . n 
B 1 84  LYS 84  88  88  LYS LYS B . n 
B 1 85  ASP 85  89  89  ASP ASP B . n 
B 1 86  LEU 86  90  90  LEU LEU B . n 
B 1 87  ASP 87  91  91  ASP ASP B . n 
B 1 88  GLU 88  92  92  GLU GLU B . n 
B 1 89  ASP 89  93  93  ASP ASP B . n 
B 1 90  ILE 90  94  94  ILE ILE B . n 
B 1 91  ARG 91  95  95  ARG ARG B . n 
B 1 92  GLY 92  96  96  GLY GLY B . n 
B 1 93  LYS 93  97  97  LYS LYS B . n 
B 1 94  ASP 94  98  98  ASP ASP B . n 
B 1 95  VAL 95  99  99  VAL VAL B . n 
B 1 96  LEU 96  100 100 LEU LEU B . n 
B 1 97  ILE 97  101 101 ILE ILE B . n 
B 1 98  VAL 98  102 102 VAL VAL B . n 
B 1 99  GLU 99  103 103 GLU GLU B . n 
B 1 100 ASP 100 104 104 ASP ASP B . n 
B 1 101 ILE 101 105 105 ILE ILE B . n 
B 1 102 ILE 102 106 106 ILE ILE B . n 
B 1 103 ASP 103 107 107 ASP ASP B . n 
B 1 104 SER 104 108 108 SER SER B . n 
B 1 105 GLY 105 109 109 GLY GLY B . n 
B 1 106 ASN 106 110 110 ASN ASN B . n 
B 1 107 THR 107 111 111 THR THR B . n 
B 1 108 LEU 108 112 112 LEU LEU B . n 
B 1 109 SER 109 113 113 SER SER B . n 
B 1 110 LYS 110 114 114 LYS LYS B . n 
B 1 111 VAL 111 115 115 VAL VAL B . n 
B 1 112 ARG 112 116 116 ARG ARG B . n 
B 1 113 GLU 113 117 117 GLU GLU B . n 
B 1 114 ILE 114 118 118 ILE ILE B . n 
B 1 115 LEU 115 119 119 LEU LEU B . n 
B 1 116 SER 116 120 120 SER SER B . n 
B 1 117 LEU 117 121 121 LEU LEU B . n 
B 1 118 ARG 118 122 122 ARG ARG B . n 
B 1 119 GLU 119 123 123 GLU GLU B . n 
B 1 120 PRO 120 124 124 PRO PRO B . n 
B 1 121 LYS 121 125 125 LYS LYS B . n 
B 1 122 SER 122 126 126 SER SER B . n 
B 1 123 LEU 123 127 127 LEU LEU B . n 
B 1 124 ALA 124 128 128 ALA ALA B . n 
B 1 125 ILE 125 129 129 ILE ILE B . n 
B 1 126 CYS 126 130 130 CYS CYS B . n 
B 1 127 THR 127 131 131 THR THR B . n 
B 1 128 LEU 128 132 132 LEU LEU B . n 
B 1 129 LEU 129 133 133 LEU LEU B . n 
B 1 130 ASP 130 134 134 ASP ASP B . n 
B 1 131 LYS 131 135 135 LYS LYS B . n 
B 1 132 PRO 132 136 136 PRO PRO B . n 
B 1 133 SER 133 137 137 SER SER B . n 
B 1 134 ARG 134 138 138 ARG ARG B . n 
B 1 135 ARG 135 139 139 ARG ARG B . n 
B 1 136 GLU 136 140 140 GLU GLU B . n 
B 1 137 VAL 137 141 141 VAL VAL B . n 
B 1 138 ASN 138 142 142 ASN ASN B . n 
B 1 139 VAL 139 143 143 VAL VAL B . n 
B 1 140 PRO 140 144 144 PRO PRO B . n 
B 1 141 VAL 141 145 145 VAL VAL B . n 
B 1 142 GLU 142 146 146 GLU GLU B . n 
B 1 143 PHE 143 147 147 PHE PHE B . n 
B 1 144 ILE 144 148 148 ILE ILE B . n 
B 1 145 GLY 145 149 149 GLY GLY B . n 
B 1 146 PHE 146 150 150 PHE PHE B . n 
B 1 147 SER 147 151 151 SER SER B . n 
B 1 148 ILE 148 152 152 ILE ILE B . n 
B 1 149 PRO 149 153 153 PRO PRO B . n 
B 1 150 ASP 150 154 154 ASP ASP B . n 
B 1 151 GLU 151 155 155 GLU GLU B . n 
B 1 152 PHE 152 156 156 PHE PHE B . n 
B 1 153 VAL 153 157 157 VAL VAL B . n 
B 1 154 VAL 154 158 158 VAL VAL B . n 
B 1 155 GLY 155 159 159 GLY GLY B . n 
B 1 156 TYR 156 160 160 TYR TYR B . n 
B 1 157 GLY 157 161 161 GLY GLY B . n 
B 1 158 ILE 158 162 162 ILE ILE B . n 
B 1 159 ASP 159 163 163 ASP ASP B . n 
B 1 160 TYR 160 164 164 TYR TYR B . n 
B 1 161 ALA 161 165 165 ALA ALA B . n 
B 1 162 GLN 162 166 166 GLN GLN B . n 
B 1 163 ARG 163 167 167 ARG ARG B . n 
B 1 164 TYR 164 168 168 TYR TYR B . n 
B 1 165 ARG 165 169 169 ARG ARG B . n 
B 1 166 HIS 166 170 170 HIS HIS B . n 
B 1 167 LEU 167 171 171 LEU LEU B . n 
B 1 168 PRO 168 172 172 PRO PRO B . n 
B 1 169 TYR 169 173 173 TYR TYR B . n 
B 1 170 ILE 170 174 174 ILE ILE B . n 
B 1 171 GLY 171 175 175 GLY GLY B . n 
B 1 172 LYS 172 176 176 LYS LYS B . n 
B 1 173 VAL 173 177 177 VAL VAL B . n 
B 1 174 ILE 174 178 178 ILE ILE B . n 
B 1 175 LEU 175 179 179 LEU LEU B . n 
B 1 176 LEU 176 180 ?   ?   ?   B . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 EPE 1  201 201 EPE EPE A . 
D 2 EPE 1  201 201 EPE EPE B . 
E 3 HOH 1  301 9   HOH HOH A . 
E 3 HOH 2  302 10  HOH HOH A . 
E 3 HOH 3  303 28  HOH HOH A . 
E 3 HOH 4  304 14  HOH HOH A . 
E 3 HOH 5  305 19  HOH HOH A . 
E 3 HOH 6  306 5   HOH HOH A . 
E 3 HOH 7  307 21  HOH HOH A . 
E 3 HOH 8  308 13  HOH HOH A . 
E 3 HOH 9  309 33  HOH HOH A . 
E 3 HOH 10 310 23  HOH HOH A . 
E 3 HOH 11 311 7   HOH HOH A . 
E 3 HOH 12 312 17  HOH HOH A . 
E 3 HOH 13 313 24  HOH HOH A . 
E 3 HOH 14 314 32  HOH HOH A . 
E 3 HOH 15 315 12  HOH HOH A . 
E 3 HOH 16 316 18  HOH HOH A . 
F 3 HOH 1  301 41  HOH HOH B . 
F 3 HOH 2  302 4   HOH HOH B . 
F 3 HOH 3  303 8   HOH HOH B . 
F 3 HOH 4  304 25  HOH HOH B . 
F 3 HOH 5  305 20  HOH HOH B . 
F 3 HOH 6  306 34  HOH HOH B . 
F 3 HOH 7  307 36  HOH HOH B . 
F 3 HOH 8  308 2   HOH HOH B . 
F 3 HOH 9  309 16  HOH HOH B . 
F 3 HOH 10 310 30  HOH HOH B . 
F 3 HOH 11 311 3   HOH HOH B . 
F 3 HOH 12 312 15  HOH HOH B . 
F 3 HOH 13 313 22  HOH HOH B . 
F 3 HOH 14 314 27  HOH HOH B . 
F 3 HOH 15 315 35  HOH HOH B . 
F 3 HOH 16 316 6   HOH HOH B . 
F 3 HOH 17 317 29  HOH HOH B . 
F 3 HOH 18 318 37  HOH HOH B . 
F 3 HOH 19 319 26  HOH HOH B . 
F 3 HOH 20 320 40  HOH HOH B . 
F 3 HOH 21 321 39  HOH HOH B . 
F 3 HOH 22 322 42  HOH HOH B . 
F 3 HOH 23 323 38  HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A MET 5  ? CG  ? A MET 1  CG  
2  1 Y 1 A MET 5  ? SD  ? A MET 1  SD  
3  1 Y 1 A MET 5  ? CE  ? A MET 1  CE  
4  1 Y 1 A LYS 6  ? CG  ? A LYS 2  CG  
5  1 Y 1 A LYS 6  ? CD  ? A LYS 2  CD  
6  1 Y 1 A LYS 6  ? CE  ? A LYS 2  CE  
7  1 Y 1 A LYS 6  ? NZ  ? A LYS 2  NZ  
8  1 Y 1 B LYS 6  ? CG  ? B LYS 2  CG  
9  1 Y 1 B LYS 6  ? CD  ? B LYS 2  CD  
10 1 Y 1 B LYS 6  ? CE  ? B LYS 2  CE  
11 1 Y 1 B LYS 6  ? NZ  ? B LYS 2  NZ  
12 1 Y 1 B GLU 31 ? CG  ? B GLU 27 CG  
13 1 Y 1 B GLU 31 ? CD  ? B GLU 27 CD  
14 1 Y 1 B GLU 31 ? OE1 ? B GLU 27 OE1 
15 1 Y 1 B GLU 31 ? OE2 ? B GLU 27 OE2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC  ? ? ? 5.8.0267 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? iMOSFLM ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? SCALA   ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .        4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9K8M 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     85.217 
_cell.length_a_esd                 ? 
_cell.length_b                     85.217 
_cell.length_b_esd                 ? 
_cell.length_c                     168.279 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        12 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9K8M 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                152 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 31 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9K8M 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             4.43 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          72.25 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'ammonium sulfate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER R 1M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-05-08 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9999 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ELETTRA BEAMLINE 11.2C' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9999 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   11.2C 
_diffrn_source.pdbx_synchrotron_site       ELETTRA 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9K8M 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.08 
_reflns.d_resolution_low                               29.94 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     40751 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.67 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                4.1 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          8.00 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.13 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.08 
_reflns_shell.d_res_low                                     2.13 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2877 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               3.5 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          96.49 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.43 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            -0.00 
_refine.aniso_B[1][2]                            -0.00 
_refine.aniso_B[1][3]                            -0.00 
_refine.aniso_B[2][2]                            -0.00 
_refine.aniso_B[2][3]                            0.00 
_refine.aniso_B[3][3]                            0.00 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               46.985 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.960 
_refine.correlation_coeff_Fo_to_Fc_free          0.946 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9K8M 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.08 
_refine.ls_d_res_low                             29.94 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     40751 
_refine.ls_number_reflns_R_free                  2109 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.67 
_refine.ls_percent_reflns_R_free                 4.9 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.20509 
_refine.ls_R_factor_R_free                       0.22692 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.20396 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.132 
_refine.pdbx_overall_ESU_R_Free                  0.125 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             3.625 
_refine.overall_SU_ML                            0.094 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.08 
_refine_hist.d_res_low                        29.94 
_refine_hist.number_atoms_solvent             39 
_refine_hist.number_atoms_total               2720 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2651 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         30 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.013  0.013  2748 ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.015  2730 ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 1.908  1.644  3706 ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? 1.400  1.583  6290 ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 7.730  5.000  337  ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 28.636 20.667 150  ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 16.153 15.000 517  ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? 20.753 15.000 28   ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.079  0.200  362  ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.010  0.020  2988 ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  596  ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 4.425  4.659  1348 ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 4.420  4.658  1347 ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 5.895  6.946  1682 ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 5.895  6.948  1683 ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 5.655  5.235  1400 ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 5.646  5.236  1398 ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 7.958  7.644  2024 ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 9.213  53.384 2812 ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? 9.214  53.372 2809 ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.085 
_refine_ls_shell.d_res_low                        2.139 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             151 
_refine_ls_shell.number_reflns_R_work             2877 
_refine_ls_shell.percent_reflns_obs               96.49 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.289 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.321 
# 
_struct.entry_id                     9K8M 
_struct.title                        'Hypoxanthine-guanine phosphoribosyltransferase from E. coli with HEPES' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9K8M 
_struct_keywords.text            TRANSFERASE 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 3 ? 
F N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    HPRT_ECOL6 
_struct_ref.pdbx_db_accession          P0A9M3 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MKHTVEVMIPEAEIKARIAELGRQITERYKDSGSDMVLVGLLRGSFMFMADLCREVQVSHEVDFMTASSYGSGMSTTRDV
KILKDLDEDIRGKDVLIVEDIIDSGNTLSKVREILSLREPKSLAICTLLDKPSRREVNVPVEFIGFSIPDEFVVGYGIDY
AQRYRHLPYIGKVILL
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9K8M A 1 ? 176 ? P0A9M3 1 ? 176 ? 5 180 
2 1 9K8M B 1 ? 176 ? P0A9M3 1 ? 176 ? 5 180 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 3380  ? 
1 MORE         -4    ? 
1 'SSA (A^2)'  15020 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 PRO A 10  ? LYS A 30  ? PRO A 14  LYS A 34  1 ? 21 
HELX_P HELX_P2 AA2 SER A 45  ? ARG A 54  ? SER A 49  ARG A 58  1 ? 10 
HELX_P HELX_P3 AA3 GLY A 105 ? LEU A 117 ? GLY A 109 LEU A 121 1 ? 13 
HELX_P HELX_P4 AA4 PRO A 132 ? ARG A 135 ? PRO A 136 ARG A 139 5 ? 4  
HELX_P HELX_P5 AA5 PRO B 10  ? LYS B 30  ? PRO B 14  LYS B 34  1 ? 21 
HELX_P HELX_P6 AA6 SER B 45  ? GLU B 55  ? SER B 49  GLU B 59  1 ? 11 
HELX_P HELX_P7 AA7 GLY B 105 ? LEU B 117 ? GLY B 109 LEU B 121 1 ? 13 
HELX_P HELX_P8 AA8 PRO B 132 ? ARG B 135 ? PRO B 136 ARG B 139 5 ? 4  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 LEU 42 A . ? LEU 46 A ARG 43 A ? ARG 47 A 1 2.63 
2 LEU 42 B . ? LEU 46 B ARG 43 B ? ARG 47 B 1 1.95 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 3 ? 
AA2 ? 6 ? 
AA3 ? 3 ? 
AA4 ? 6 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? parallel      
AA2 3 4 ? parallel      
AA2 4 5 ? parallel      
AA2 5 6 ? parallel      
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? parallel      
AA4 3 4 ? parallel      
AA4 4 5 ? parallel      
AA4 5 6 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 HIS A 3   ? ILE A 9   ? HIS A 7   ILE A 13  
AA1 2 ILE A 170 ? LEU A 175 ? ILE A 174 LEU A 179 
AA1 3 VAL A 153 ? VAL A 154 ? VAL A 157 VAL A 158 
AA2 1 ILE A 82  ? LYS A 84  ? ILE A 86  LYS A 88  
AA2 2 GLU A 61  ? ALA A 67  ? GLU A 65  ALA A 71  
AA2 3 MET A 36  ? LEU A 41  ? MET A 40  LEU A 45  
AA2 4 ASP A 94  ? ILE A 102 ? ASP A 98  ILE A 106 
AA2 5 SER A 122 ? ASP A 130 ? SER A 126 ASP A 134 
AA2 6 PHE A 143 ? SER A 147 ? PHE A 147 SER A 151 
AA3 1 THR B 4   ? ILE B 9   ? THR B 8   ILE B 13  
AA3 2 ILE B 170 ? ILE B 174 ? ILE B 174 ILE B 178 
AA3 3 VAL B 153 ? VAL B 154 ? VAL B 157 VAL B 158 
AA4 1 ILE B 82  ? LYS B 84  ? ILE B 86  LYS B 88  
AA4 2 GLU B 61  ? ALA B 67  ? GLU B 65  ALA B 71  
AA4 3 MET B 36  ? LEU B 41  ? MET B 40  LEU B 45  
AA4 4 ASP B 94  ? ILE B 102 ? ASP B 98  ILE B 106 
AA4 5 SER B 122 ? ASP B 130 ? SER B 126 ASP B 134 
AA4 6 PHE B 143 ? SER B 147 ? PHE B 147 SER B 151 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N MET A 8   ? N MET A 12  O ILE A 170 ? O ILE A 174 
AA1 2 3 O GLY A 171 ? O GLY A 175 N VAL A 154 ? N VAL A 158 
AA2 1 2 O LEU A 83  ? O LEU A 87  N THR A 66  ? N THR A 70  
AA2 2 3 O ASP A 63  ? O ASP A 67  N LEU A 38  ? N LEU A 42  
AA2 3 4 N VAL A 39  ? N VAL A 43  O VAL A 98  ? O VAL A 102 
AA2 4 5 N ILE A 97  ? N ILE A 101 O ALA A 124 ? O ALA A 128 
AA2 5 6 N THR A 127 ? N THR A 131 O PHE A 143 ? O PHE A 147 
AA3 1 2 N GLU B 6   ? N GLU B 10  O LYS B 172 ? O LYS B 176 
AA3 2 3 O GLY B 171 ? O GLY B 175 N VAL B 154 ? N VAL B 158 
AA4 1 2 O LYS B 84  ? O LYS B 88  N THR B 66  ? N THR B 70  
AA4 2 3 O ASP B 63  ? O ASP B 67  N LEU B 38  ? N LEU B 42  
AA4 3 4 N VAL B 39  ? N VAL B 43  O VAL B 98  ? O VAL B 102 
AA4 4 5 N ILE B 97  ? N ILE B 101 O ALA B 124 ? O ALA B 128 
AA4 5 6 N THR B 127 ? N THR B 131 O PHE B 143 ? O PHE B 147 
# 
_pdbx_entry_details.entry_id                   9K8M 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             CG 
_pdbx_validate_rmsd_angle.auth_asym_id_1             B 
_pdbx_validate_rmsd_angle.auth_comp_id_1             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_1              138 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CD 
_pdbx_validate_rmsd_angle.auth_asym_id_2             B 
_pdbx_validate_rmsd_angle.auth_comp_id_2             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_2              138 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             NE 
_pdbx_validate_rmsd_angle.auth_asym_id_3             B 
_pdbx_validate_rmsd_angle.auth_comp_id_3             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_3              138 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                124.79 
_pdbx_validate_rmsd_angle.angle_target_value         111.80 
_pdbx_validate_rmsd_angle.angle_deviation            12.99 
_pdbx_validate_rmsd_angle.angle_standard_deviation   2.10 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 GLN A 61  ? ? -94.59  47.26   
2 1 ASP A 107 ? ? -119.50 -83.02  
3 1 PRO A 153 ? ? -67.89  -178.05 
4 1 GLN B 61  ? ? -94.37  46.60   
5 1 ASP B 107 ? ? -121.87 -80.15  
6 1 LYS B 135 ? ? -109.69 78.88   
7 1 GLN B 166 ? ? 72.76   -9.84   
8 1 TYR B 168 ? ? 82.44   5.95    
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A TYR 74  ? A TYR 70  
2  1 Y 1 A GLY 75  ? A GLY 71  
3  1 Y 1 A SER 76  ? A SER 72  
4  1 Y 1 A GLY 77  ? A GLY 73  
5  1 Y 1 A MET 78  ? A MET 74  
6  1 Y 1 A SER 79  ? A SER 75  
7  1 Y 1 A THR 80  ? A THR 76  
8  1 Y 1 B MET 5   ? B MET 1   
9  1 Y 1 B SER 73  ? B SER 69  
10 1 Y 1 B TYR 74  ? B TYR 70  
11 1 Y 1 B GLY 75  ? B GLY 71  
12 1 Y 1 B SER 76  ? B SER 72  
13 1 Y 1 B GLY 77  ? B GLY 73  
14 1 Y 1 B MET 78  ? B MET 74  
15 1 Y 1 B SER 79  ? B SER 75  
16 1 Y 1 B THR 80  ? B THR 76  
17 1 Y 1 B LEU 180 ? B LEU 176 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
EPE N1   N N N 88  
EPE C2   C N N 89  
EPE C3   C N N 90  
EPE N4   N N N 91  
EPE C5   C N N 92  
EPE C6   C N N 93  
EPE C7   C N N 94  
EPE C8   C N N 95  
EPE O8   O N N 96  
EPE C9   C N N 97  
EPE C10  C N N 98  
EPE S    S N N 99  
EPE O1S  O N N 100 
EPE O2S  O N N 101 
EPE O3S  O N N 102 
EPE H21  H N N 103 
EPE H22  H N N 104 
EPE H31  H N N 105 
EPE H32  H N N 106 
EPE H51  H N N 107 
EPE H52  H N N 108 
EPE H61  H N N 109 
EPE H62  H N N 110 
EPE H71  H N N 111 
EPE H72  H N N 112 
EPE H81  H N N 113 
EPE H82  H N N 114 
EPE HO8  H N N 115 
EPE H91  H N N 116 
EPE H92  H N N 117 
EPE H101 H N N 118 
EPE H102 H N N 119 
EPE HOS3 H N N 120 
GLN N    N N N 121 
GLN CA   C N S 122 
GLN C    C N N 123 
GLN O    O N N 124 
GLN CB   C N N 125 
GLN CG   C N N 126 
GLN CD   C N N 127 
GLN OE1  O N N 128 
GLN NE2  N N N 129 
GLN OXT  O N N 130 
GLN H    H N N 131 
GLN H2   H N N 132 
GLN HA   H N N 133 
GLN HB2  H N N 134 
GLN HB3  H N N 135 
GLN HG2  H N N 136 
GLN HG3  H N N 137 
GLN HE21 H N N 138 
GLN HE22 H N N 139 
GLN HXT  H N N 140 
GLU N    N N N 141 
GLU CA   C N S 142 
GLU C    C N N 143 
GLU O    O N N 144 
GLU CB   C N N 145 
GLU CG   C N N 146 
GLU CD   C N N 147 
GLU OE1  O N N 148 
GLU OE2  O N N 149 
GLU OXT  O N N 150 
GLU H    H N N 151 
GLU H2   H N N 152 
GLU HA   H N N 153 
GLU HB2  H N N 154 
GLU HB3  H N N 155 
GLU HG2  H N N 156 
GLU HG3  H N N 157 
GLU HE2  H N N 158 
GLU HXT  H N N 159 
GLY N    N N N 160 
GLY CA   C N N 161 
GLY C    C N N 162 
GLY O    O N N 163 
GLY OXT  O N N 164 
GLY H    H N N 165 
GLY H2   H N N 166 
GLY HA2  H N N 167 
GLY HA3  H N N 168 
GLY HXT  H N N 169 
HIS N    N N N 170 
HIS CA   C N S 171 
HIS C    C N N 172 
HIS O    O N N 173 
HIS CB   C N N 174 
HIS CG   C Y N 175 
HIS ND1  N Y N 176 
HIS CD2  C Y N 177 
HIS CE1  C Y N 178 
HIS NE2  N Y N 179 
HIS OXT  O N N 180 
HIS H    H N N 181 
HIS H2   H N N 182 
HIS HA   H N N 183 
HIS HB2  H N N 184 
HIS HB3  H N N 185 
HIS HD1  H N N 186 
HIS HD2  H N N 187 
HIS HE1  H N N 188 
HIS HE2  H N N 189 
HIS HXT  H N N 190 
HOH O    O N N 191 
HOH H1   H N N 192 
HOH H2   H N N 193 
ILE N    N N N 194 
ILE CA   C N S 195 
ILE C    C N N 196 
ILE O    O N N 197 
ILE CB   C N S 198 
ILE CG1  C N N 199 
ILE CG2  C N N 200 
ILE CD1  C N N 201 
ILE OXT  O N N 202 
ILE H    H N N 203 
ILE H2   H N N 204 
ILE HA   H N N 205 
ILE HB   H N N 206 
ILE HG12 H N N 207 
ILE HG13 H N N 208 
ILE HG21 H N N 209 
ILE HG22 H N N 210 
ILE HG23 H N N 211 
ILE HD11 H N N 212 
ILE HD12 H N N 213 
ILE HD13 H N N 214 
ILE HXT  H N N 215 
LEU N    N N N 216 
LEU CA   C N S 217 
LEU C    C N N 218 
LEU O    O N N 219 
LEU CB   C N N 220 
LEU CG   C N N 221 
LEU CD1  C N N 222 
LEU CD2  C N N 223 
LEU OXT  O N N 224 
LEU H    H N N 225 
LEU H2   H N N 226 
LEU HA   H N N 227 
LEU HB2  H N N 228 
LEU HB3  H N N 229 
LEU HG   H N N 230 
LEU HD11 H N N 231 
LEU HD12 H N N 232 
LEU HD13 H N N 233 
LEU HD21 H N N 234 
LEU HD22 H N N 235 
LEU HD23 H N N 236 
LEU HXT  H N N 237 
LYS N    N N N 238 
LYS CA   C N S 239 
LYS C    C N N 240 
LYS O    O N N 241 
LYS CB   C N N 242 
LYS CG   C N N 243 
LYS CD   C N N 244 
LYS CE   C N N 245 
LYS NZ   N N N 246 
LYS OXT  O N N 247 
LYS H    H N N 248 
LYS H2   H N N 249 
LYS HA   H N N 250 
LYS HB2  H N N 251 
LYS HB3  H N N 252 
LYS HG2  H N N 253 
LYS HG3  H N N 254 
LYS HD2  H N N 255 
LYS HD3  H N N 256 
LYS HE2  H N N 257 
LYS HE3  H N N 258 
LYS HZ1  H N N 259 
LYS HZ2  H N N 260 
LYS HZ3  H N N 261 
LYS HXT  H N N 262 
MET N    N N N 263 
MET CA   C N S 264 
MET C    C N N 265 
MET O    O N N 266 
MET CB   C N N 267 
MET CG   C N N 268 
MET SD   S N N 269 
MET CE   C N N 270 
MET OXT  O N N 271 
MET H    H N N 272 
MET H2   H N N 273 
MET HA   H N N 274 
MET HB2  H N N 275 
MET HB3  H N N 276 
MET HG2  H N N 277 
MET HG3  H N N 278 
MET HE1  H N N 279 
MET HE2  H N N 280 
MET HE3  H N N 281 
MET HXT  H N N 282 
PHE N    N N N 283 
PHE CA   C N S 284 
PHE C    C N N 285 
PHE O    O N N 286 
PHE CB   C N N 287 
PHE CG   C Y N 288 
PHE CD1  C Y N 289 
PHE CD2  C Y N 290 
PHE CE1  C Y N 291 
PHE CE2  C Y N 292 
PHE CZ   C Y N 293 
PHE OXT  O N N 294 
PHE H    H N N 295 
PHE H2   H N N 296 
PHE HA   H N N 297 
PHE HB2  H N N 298 
PHE HB3  H N N 299 
PHE HD1  H N N 300 
PHE HD2  H N N 301 
PHE HE1  H N N 302 
PHE HE2  H N N 303 
PHE HZ   H N N 304 
PHE HXT  H N N 305 
PRO N    N N N 306 
PRO CA   C N S 307 
PRO C    C N N 308 
PRO O    O N N 309 
PRO CB   C N N 310 
PRO CG   C N N 311 
PRO CD   C N N 312 
PRO OXT  O N N 313 
PRO H    H N N 314 
PRO HA   H N N 315 
PRO HB2  H N N 316 
PRO HB3  H N N 317 
PRO HG2  H N N 318 
PRO HG3  H N N 319 
PRO HD2  H N N 320 
PRO HD3  H N N 321 
PRO HXT  H N N 322 
SER N    N N N 323 
SER CA   C N S 324 
SER C    C N N 325 
SER O    O N N 326 
SER CB   C N N 327 
SER OG   O N N 328 
SER OXT  O N N 329 
SER H    H N N 330 
SER H2   H N N 331 
SER HA   H N N 332 
SER HB2  H N N 333 
SER HB3  H N N 334 
SER HG   H N N 335 
SER HXT  H N N 336 
THR N    N N N 337 
THR CA   C N S 338 
THR C    C N N 339 
THR O    O N N 340 
THR CB   C N R 341 
THR OG1  O N N 342 
THR CG2  C N N 343 
THR OXT  O N N 344 
THR H    H N N 345 
THR H2   H N N 346 
THR HA   H N N 347 
THR HB   H N N 348 
THR HG1  H N N 349 
THR HG21 H N N 350 
THR HG22 H N N 351 
THR HG23 H N N 352 
THR HXT  H N N 353 
TYR N    N N N 354 
TYR CA   C N S 355 
TYR C    C N N 356 
TYR O    O N N 357 
TYR CB   C N N 358 
TYR CG   C Y N 359 
TYR CD1  C Y N 360 
TYR CD2  C Y N 361 
TYR CE1  C Y N 362 
TYR CE2  C Y N 363 
TYR CZ   C Y N 364 
TYR OH   O N N 365 
TYR OXT  O N N 366 
TYR H    H N N 367 
TYR H2   H N N 368 
TYR HA   H N N 369 
TYR HB2  H N N 370 
TYR HB3  H N N 371 
TYR HD1  H N N 372 
TYR HD2  H N N 373 
TYR HE1  H N N 374 
TYR HE2  H N N 375 
TYR HH   H N N 376 
TYR HXT  H N N 377 
VAL N    N N N 378 
VAL CA   C N S 379 
VAL C    C N N 380 
VAL O    O N N 381 
VAL CB   C N N 382 
VAL CG1  C N N 383 
VAL CG2  C N N 384 
VAL OXT  O N N 385 
VAL H    H N N 386 
VAL H2   H N N 387 
VAL HA   H N N 388 
VAL HB   H N N 389 
VAL HG11 H N N 390 
VAL HG12 H N N 391 
VAL HG13 H N N 392 
VAL HG21 H N N 393 
VAL HG22 H N N 394 
VAL HG23 H N N 395 
VAL HXT  H N N 396 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
EPE N1  C2   sing N N 83  
EPE N1  C6   sing N N 84  
EPE N1  C9   sing N N 85  
EPE C2  C3   sing N N 86  
EPE C2  H21  sing N N 87  
EPE C2  H22  sing N N 88  
EPE C3  N4   sing N N 89  
EPE C3  H31  sing N N 90  
EPE C3  H32  sing N N 91  
EPE N4  C5   sing N N 92  
EPE N4  C7   sing N N 93  
EPE C5  C6   sing N N 94  
EPE C5  H51  sing N N 95  
EPE C5  H52  sing N N 96  
EPE C6  H61  sing N N 97  
EPE C6  H62  sing N N 98  
EPE C7  C8   sing N N 99  
EPE C7  H71  sing N N 100 
EPE C7  H72  sing N N 101 
EPE C8  O8   sing N N 102 
EPE C8  H81  sing N N 103 
EPE C8  H82  sing N N 104 
EPE O8  HO8  sing N N 105 
EPE C9  C10  sing N N 106 
EPE C9  H91  sing N N 107 
EPE C9  H92  sing N N 108 
EPE C10 S    sing N N 109 
EPE C10 H101 sing N N 110 
EPE C10 H102 sing N N 111 
EPE S   O1S  doub N N 112 
EPE S   O2S  doub N N 113 
EPE S   O3S  sing N N 114 
EPE O3S HOS3 sing N N 115 
GLN N   CA   sing N N 116 
GLN N   H    sing N N 117 
GLN N   H2   sing N N 118 
GLN CA  C    sing N N 119 
GLN CA  CB   sing N N 120 
GLN CA  HA   sing N N 121 
GLN C   O    doub N N 122 
GLN C   OXT  sing N N 123 
GLN CB  CG   sing N N 124 
GLN CB  HB2  sing N N 125 
GLN CB  HB3  sing N N 126 
GLN CG  CD   sing N N 127 
GLN CG  HG2  sing N N 128 
GLN CG  HG3  sing N N 129 
GLN CD  OE1  doub N N 130 
GLN CD  NE2  sing N N 131 
GLN NE2 HE21 sing N N 132 
GLN NE2 HE22 sing N N 133 
GLN OXT HXT  sing N N 134 
GLU N   CA   sing N N 135 
GLU N   H    sing N N 136 
GLU N   H2   sing N N 137 
GLU CA  C    sing N N 138 
GLU CA  CB   sing N N 139 
GLU CA  HA   sing N N 140 
GLU C   O    doub N N 141 
GLU C   OXT  sing N N 142 
GLU CB  CG   sing N N 143 
GLU CB  HB2  sing N N 144 
GLU CB  HB3  sing N N 145 
GLU CG  CD   sing N N 146 
GLU CG  HG2  sing N N 147 
GLU CG  HG3  sing N N 148 
GLU CD  OE1  doub N N 149 
GLU CD  OE2  sing N N 150 
GLU OE2 HE2  sing N N 151 
GLU OXT HXT  sing N N 152 
GLY N   CA   sing N N 153 
GLY N   H    sing N N 154 
GLY N   H2   sing N N 155 
GLY CA  C    sing N N 156 
GLY CA  HA2  sing N N 157 
GLY CA  HA3  sing N N 158 
GLY C   O    doub N N 159 
GLY C   OXT  sing N N 160 
GLY OXT HXT  sing N N 161 
HIS N   CA   sing N N 162 
HIS N   H    sing N N 163 
HIS N   H2   sing N N 164 
HIS CA  C    sing N N 165 
HIS CA  CB   sing N N 166 
HIS CA  HA   sing N N 167 
HIS C   O    doub N N 168 
HIS C   OXT  sing N N 169 
HIS CB  CG   sing N N 170 
HIS CB  HB2  sing N N 171 
HIS CB  HB3  sing N N 172 
HIS CG  ND1  sing Y N 173 
HIS CG  CD2  doub Y N 174 
HIS ND1 CE1  doub Y N 175 
HIS ND1 HD1  sing N N 176 
HIS CD2 NE2  sing Y N 177 
HIS CD2 HD2  sing N N 178 
HIS CE1 NE2  sing Y N 179 
HIS CE1 HE1  sing N N 180 
HIS NE2 HE2  sing N N 181 
HIS OXT HXT  sing N N 182 
HOH O   H1   sing N N 183 
HOH O   H2   sing N N 184 
ILE N   CA   sing N N 185 
ILE N   H    sing N N 186 
ILE N   H2   sing N N 187 
ILE CA  C    sing N N 188 
ILE CA  CB   sing N N 189 
ILE CA  HA   sing N N 190 
ILE C   O    doub N N 191 
ILE C   OXT  sing N N 192 
ILE CB  CG1  sing N N 193 
ILE CB  CG2  sing N N 194 
ILE CB  HB   sing N N 195 
ILE CG1 CD1  sing N N 196 
ILE CG1 HG12 sing N N 197 
ILE CG1 HG13 sing N N 198 
ILE CG2 HG21 sing N N 199 
ILE CG2 HG22 sing N N 200 
ILE CG2 HG23 sing N N 201 
ILE CD1 HD11 sing N N 202 
ILE CD1 HD12 sing N N 203 
ILE CD1 HD13 sing N N 204 
ILE OXT HXT  sing N N 205 
LEU N   CA   sing N N 206 
LEU N   H    sing N N 207 
LEU N   H2   sing N N 208 
LEU CA  C    sing N N 209 
LEU CA  CB   sing N N 210 
LEU CA  HA   sing N N 211 
LEU C   O    doub N N 212 
LEU C   OXT  sing N N 213 
LEU CB  CG   sing N N 214 
LEU CB  HB2  sing N N 215 
LEU CB  HB3  sing N N 216 
LEU CG  CD1  sing N N 217 
LEU CG  CD2  sing N N 218 
LEU CG  HG   sing N N 219 
LEU CD1 HD11 sing N N 220 
LEU CD1 HD12 sing N N 221 
LEU CD1 HD13 sing N N 222 
LEU CD2 HD21 sing N N 223 
LEU CD2 HD22 sing N N 224 
LEU CD2 HD23 sing N N 225 
LEU OXT HXT  sing N N 226 
LYS N   CA   sing N N 227 
LYS N   H    sing N N 228 
LYS N   H2   sing N N 229 
LYS CA  C    sing N N 230 
LYS CA  CB   sing N N 231 
LYS CA  HA   sing N N 232 
LYS C   O    doub N N 233 
LYS C   OXT  sing N N 234 
LYS CB  CG   sing N N 235 
LYS CB  HB2  sing N N 236 
LYS CB  HB3  sing N N 237 
LYS CG  CD   sing N N 238 
LYS CG  HG2  sing N N 239 
LYS CG  HG3  sing N N 240 
LYS CD  CE   sing N N 241 
LYS CD  HD2  sing N N 242 
LYS CD  HD3  sing N N 243 
LYS CE  NZ   sing N N 244 
LYS CE  HE2  sing N N 245 
LYS CE  HE3  sing N N 246 
LYS NZ  HZ1  sing N N 247 
LYS NZ  HZ2  sing N N 248 
LYS NZ  HZ3  sing N N 249 
LYS OXT HXT  sing N N 250 
MET N   CA   sing N N 251 
MET N   H    sing N N 252 
MET N   H2   sing N N 253 
MET CA  C    sing N N 254 
MET CA  CB   sing N N 255 
MET CA  HA   sing N N 256 
MET C   O    doub N N 257 
MET C   OXT  sing N N 258 
MET CB  CG   sing N N 259 
MET CB  HB2  sing N N 260 
MET CB  HB3  sing N N 261 
MET CG  SD   sing N N 262 
MET CG  HG2  sing N N 263 
MET CG  HG3  sing N N 264 
MET SD  CE   sing N N 265 
MET CE  HE1  sing N N 266 
MET CE  HE2  sing N N 267 
MET CE  HE3  sing N N 268 
MET OXT HXT  sing N N 269 
PHE N   CA   sing N N 270 
PHE N   H    sing N N 271 
PHE N   H2   sing N N 272 
PHE CA  C    sing N N 273 
PHE CA  CB   sing N N 274 
PHE CA  HA   sing N N 275 
PHE C   O    doub N N 276 
PHE C   OXT  sing N N 277 
PHE CB  CG   sing N N 278 
PHE CB  HB2  sing N N 279 
PHE CB  HB3  sing N N 280 
PHE CG  CD1  doub Y N 281 
PHE CG  CD2  sing Y N 282 
PHE CD1 CE1  sing Y N 283 
PHE CD1 HD1  sing N N 284 
PHE CD2 CE2  doub Y N 285 
PHE CD2 HD2  sing N N 286 
PHE CE1 CZ   doub Y N 287 
PHE CE1 HE1  sing N N 288 
PHE CE2 CZ   sing Y N 289 
PHE CE2 HE2  sing N N 290 
PHE CZ  HZ   sing N N 291 
PHE OXT HXT  sing N N 292 
PRO N   CA   sing N N 293 
PRO N   CD   sing N N 294 
PRO N   H    sing N N 295 
PRO CA  C    sing N N 296 
PRO CA  CB   sing N N 297 
PRO CA  HA   sing N N 298 
PRO C   O    doub N N 299 
PRO C   OXT  sing N N 300 
PRO CB  CG   sing N N 301 
PRO CB  HB2  sing N N 302 
PRO CB  HB3  sing N N 303 
PRO CG  CD   sing N N 304 
PRO CG  HG2  sing N N 305 
PRO CG  HG3  sing N N 306 
PRO CD  HD2  sing N N 307 
PRO CD  HD3  sing N N 308 
PRO OXT HXT  sing N N 309 
SER N   CA   sing N N 310 
SER N   H    sing N N 311 
SER N   H2   sing N N 312 
SER CA  C    sing N N 313 
SER CA  CB   sing N N 314 
SER CA  HA   sing N N 315 
SER C   O    doub N N 316 
SER C   OXT  sing N N 317 
SER CB  OG   sing N N 318 
SER CB  HB2  sing N N 319 
SER CB  HB3  sing N N 320 
SER OG  HG   sing N N 321 
SER OXT HXT  sing N N 322 
THR N   CA   sing N N 323 
THR N   H    sing N N 324 
THR N   H2   sing N N 325 
THR CA  C    sing N N 326 
THR CA  CB   sing N N 327 
THR CA  HA   sing N N 328 
THR C   O    doub N N 329 
THR C   OXT  sing N N 330 
THR CB  OG1  sing N N 331 
THR CB  CG2  sing N N 332 
THR CB  HB   sing N N 333 
THR OG1 HG1  sing N N 334 
THR CG2 HG21 sing N N 335 
THR CG2 HG22 sing N N 336 
THR CG2 HG23 sing N N 337 
THR OXT HXT  sing N N 338 
TYR N   CA   sing N N 339 
TYR N   H    sing N N 340 
TYR N   H2   sing N N 341 
TYR CA  C    sing N N 342 
TYR CA  CB   sing N N 343 
TYR CA  HA   sing N N 344 
TYR C   O    doub N N 345 
TYR C   OXT  sing N N 346 
TYR CB  CG   sing N N 347 
TYR CB  HB2  sing N N 348 
TYR CB  HB3  sing N N 349 
TYR CG  CD1  doub Y N 350 
TYR CG  CD2  sing Y N 351 
TYR CD1 CE1  sing Y N 352 
TYR CD1 HD1  sing N N 353 
TYR CD2 CE2  doub Y N 354 
TYR CD2 HD2  sing N N 355 
TYR CE1 CZ   doub Y N 356 
TYR CE1 HE1  sing N N 357 
TYR CE2 CZ   sing Y N 358 
TYR CE2 HE2  sing N N 359 
TYR CZ  OH   sing N N 360 
TYR OH  HH   sing N N 361 
TYR OXT HXT  sing N N 362 
VAL N   CA   sing N N 363 
VAL N   H    sing N N 364 
VAL N   H2   sing N N 365 
VAL CA  C    sing N N 366 
VAL CA  CB   sing N N 367 
VAL CA  HA   sing N N 368 
VAL C   O    doub N N 369 
VAL C   OXT  sing N N 370 
VAL CB  CG1  sing N N 371 
VAL CB  CG2  sing N N 372 
VAL CB  HB   sing N N 373 
VAL CG1 HG11 sing N N 374 
VAL CG1 HG12 sing N N 375 
VAL CG1 HG13 sing N N 376 
VAL CG2 HG21 sing N N 377 
VAL CG2 HG22 sing N N 378 
VAL CG2 HG23 sing N N 379 
VAL OXT HXT  sing N N 380 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   8CAG 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9K8M 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.011735 
_atom_sites.fract_transf_matrix[1][2]   0.006775 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013550 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.005943 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . MET A 1 1   ? -69.076 2.555   -11.474 1.00 78.06  ? 5   MET A N   1 
ATOM   2    C CA  . MET A 1 1   ? -70.054 2.005   -10.495 1.00 76.60  ? 5   MET A CA  1 
ATOM   3    C C   . MET A 1 1   ? -69.760 2.594   -9.107  1.00 78.56  ? 5   MET A C   1 
ATOM   4    O O   . MET A 1 1   ? -68.557 2.662   -8.736  1.00 86.21  ? 5   MET A O   1 
ATOM   5    C CB  . MET A 1 1   ? -69.967 0.473   -10.443 1.00 69.96  ? 5   MET A CB  1 
ATOM   6    N N   . LYS A 1 2   ? -70.800 3.031   -8.378  1.00 81.06  ? 6   LYS A N   1 
ATOM   7    C CA  . LYS A 1 2   ? -70.748 3.194   -6.900  1.00 75.32  ? 6   LYS A CA  1 
ATOM   8    C C   . LYS A 1 2   ? -70.198 1.865   -6.348  1.00 79.54  ? 6   LYS A C   1 
ATOM   9    O O   . LYS A 1 2   ? -70.566 0.780   -6.885  1.00 76.15  ? 6   LYS A O   1 
ATOM   10   C CB  . LYS A 1 2   ? -72.110 3.581   -6.297  1.00 69.21  ? 6   LYS A CB  1 
ATOM   11   N N   . HIS A 1 3   ? -69.294 1.943   -5.369  1.00 74.69  ? 7   HIS A N   1 
ATOM   12   C CA  . HIS A 1 3   ? -68.593 0.780   -4.775  1.00 73.84  ? 7   HIS A CA  1 
ATOM   13   C C   . HIS A 1 3   ? -67.844 1.183   -3.509  1.00 69.81  ? 7   HIS A C   1 
ATOM   14   O O   . HIS A 1 3   ? -67.708 2.372   -3.249  1.00 67.59  ? 7   HIS A O   1 
ATOM   15   C CB  . HIS A 1 3   ? -67.606 0.169   -5.778  1.00 73.72  ? 7   HIS A CB  1 
ATOM   16   C CG  . HIS A 1 3   ? -66.392 1.002   -5.991  1.00 71.76  ? 7   HIS A CG  1 
ATOM   17   N ND1 . HIS A 1 3   ? -66.312 1.932   -7.009  1.00 69.14  ? 7   HIS A ND1 1 
ATOM   18   C CD2 . HIS A 1 3   ? -65.218 1.050   -5.325  1.00 66.68  ? 7   HIS A CD2 1 
ATOM   19   C CE1 . HIS A 1 3   ? -65.131 2.497   -6.981  1.00 66.78  ? 7   HIS A CE1 1 
ATOM   20   N NE2 . HIS A 1 3   ? -64.439 1.971   -5.957  1.00 71.62  ? 7   HIS A NE2 1 
ATOM   21   N N   . THR A 1 4   ? -67.320 0.181   -2.809  1.00 69.24  ? 8   THR A N   1 
ATOM   22   C CA  . THR A 1 4   ? -66.471 0.318   -1.606  1.00 68.38  ? 8   THR A CA  1 
ATOM   23   C C   . THR A 1 4   ? -65.320 -0.710  -1.689  1.00 63.19  ? 8   THR A C   1 
ATOM   24   O O   . THR A 1 4   ? -65.402 -1.670  -2.474  1.00 56.24  ? 8   THR A O   1 
ATOM   25   C CB  . THR A 1 4   ? -67.389 0.250   -0.372  1.00 75.09  ? 8   THR A CB  1 
ATOM   26   O OG1 . THR A 1 4   ? -66.836 1.185   0.553   1.00 76.14  ? 8   THR A OG1 1 
ATOM   27   C CG2 . THR A 1 4   ? -67.544 -1.131  0.241   1.00 65.30  ? 8   THR A CG2 1 
ATOM   28   N N   . VAL A 1 5   ? -64.276 -0.512  -0.900  1.00 49.73  ? 9   VAL A N   1 
ATOM   29   C CA  . VAL A 1 5   ? -63.127 -1.446  -0.796  1.00 53.78  ? 9   VAL A CA  1 
ATOM   30   C C   . VAL A 1 5   ? -62.969 -1.842  0.655   1.00 51.92  ? 9   VAL A C   1 
ATOM   31   O O   . VAL A 1 5   ? -62.871 -0.936  1.477   1.00 62.29  ? 9   VAL A O   1 
ATOM   32   C CB  . VAL A 1 5   ? -61.840 -0.783  -1.300  1.00 46.64  ? 9   VAL A CB  1 
ATOM   33   C CG1 . VAL A 1 5   ? -60.654 -1.722  -1.204  1.00 44.10  ? 9   VAL A CG1 1 
ATOM   34   C CG2 . VAL A 1 5   ? -62.053 -0.312  -2.721  1.00 47.60  ? 9   VAL A CG2 1 
ATOM   35   N N   . GLU A 1 6   ? -62.890 -3.139  0.938   1.00 52.94  ? 10  GLU A N   1 
ATOM   36   C CA  . GLU A 1 6   ? -62.524 -3.667  2.280   1.00 50.42  ? 10  GLU A CA  1 
ATOM   37   C C   . GLU A 1 6   ? -61.184 -4.381  2.215   1.00 41.67  ? 10  GLU A C   1 
ATOM   38   O O   . GLU A 1 6   ? -60.879 -5.007  1.197   1.00 45.54  ? 10  GLU A O   1 
ATOM   39   C CB  . GLU A 1 6   ? -63.409 -4.807  2.775   1.00 60.49  ? 10  GLU A CB  1 
ATOM   40   C CG  . GLU A 1 6   ? -64.881 -4.718  2.476   1.00 71.82  ? 10  GLU A CG  1 
ATOM   41   C CD  . GLU A 1 6   ? -65.536 -5.962  3.069   1.00 80.90  ? 10  GLU A CD  1 
ATOM   42   O OE1 . GLU A 1 6   ? -65.214 -7.114  2.607   1.00 72.70  ? 10  GLU A OE1 1 
ATOM   43   O OE2 . GLU A 1 6   ? -66.274 -5.794  4.052   1.00 72.16  ? 10  GLU A OE2 1 
ATOM   44   N N   . VAL A 1 7   ? -60.490 -4.473  3.329   1.00 41.27  ? 11  VAL A N   1 
ATOM   45   C CA  . VAL A 1 7   ? -59.218 -5.226  3.355   1.00 46.30  ? 11  VAL A CA  1 
ATOM   46   C C   . VAL A 1 7   ? -59.539 -6.729  3.276   1.00 50.21  ? 11  VAL A C   1 
ATOM   47   O O   . VAL A 1 7   ? -60.396 -7.167  4.036   1.00 47.94  ? 11  VAL A O   1 
ATOM   48   C CB  . VAL A 1 7   ? -58.409 -4.839  4.590   1.00 48.25  ? 11  VAL A CB  1 
ATOM   49   C CG1 . VAL A 1 7   ? -57.149 -5.677  4.683   1.00 45.19  ? 11  VAL A CG1 1 
ATOM   50   C CG2 . VAL A 1 7   ? -58.098 -3.343  4.557   1.00 52.13  ? 11  VAL A CG2 1 
ATOM   51   N N   . MET A 1 8   ? -58.874 -7.462  2.375   1.00 48.73  ? 12  MET A N   1 
ATOM   52   C CA  . MET A 1 8   ? -58.939 -8.943  2.276   1.00 42.42  ? 12  MET A CA  1 
ATOM   53   C C   . MET A 1 8   ? -57.597 -9.524  2.737   1.00 46.27  ? 12  MET A C   1 
ATOM   54   O O   . MET A 1 8   ? -57.564 -10.420 3.615   1.00 44.16  ? 12  MET A O   1 
ATOM   55   C CB  . MET A 1 8   ? -59.243 -9.352  0.834   1.00 42.39  ? 12  MET A CB  1 
ATOM   56   C CG  . MET A 1 8   ? -59.313 -10.846 0.614   1.00 44.55  ? 12  MET A CG  1 
ATOM   57   S SD  . MET A 1 8   ? -59.762 -11.256 -1.087  1.00 49.57  ? 12  MET A SD  1 
ATOM   58   C CE  . MET A 1 8   ? -59.046 -12.884 -1.270  1.00 50.70  ? 12  MET A CE  1 
ATOM   59   N N   . ILE A 1 9   ? -56.483 -9.018  2.232   1.00 40.69  ? 13  ILE A N   1 
ATOM   60   C CA  . ILE A 1 9   ? -55.170 -9.527  2.697   1.00 39.32  ? 13  ILE A CA  1 
ATOM   61   C C   . ILE A 1 9   ? -54.370 -8.312  3.138   1.00 49.83  ? 13  ILE A C   1 
ATOM   62   O O   . ILE A 1 9   ? -53.868 -7.553  2.294   1.00 39.19  ? 13  ILE A O   1 
ATOM   63   C CB  . ILE A 1 9   ? -54.424 -10.321 1.633   1.00 38.12  ? 13  ILE A CB  1 
ATOM   64   C CG1 . ILE A 1 9   ? -55.339 -11.306 0.889   1.00 42.81  ? 13  ILE A CG1 1 
ATOM   65   C CG2 . ILE A 1 9   ? -53.228 -10.988 2.286   1.00 38.41  ? 13  ILE A CG2 1 
ATOM   66   C CD1 . ILE A 1 9   ? -54.606 -12.162 -0.087  1.00 39.97  ? 13  ILE A CD1 1 
ATOM   67   N N   . PRO A 1 10  ? -54.191 -8.140  4.462   1.00 49.90  ? 14  PRO A N   1 
ATOM   68   C CA  . PRO A 1 10  ? -53.443 -7.001  4.989   1.00 42.17  ? 14  PRO A CA  1 
ATOM   69   C C   . PRO A 1 10  ? -51.962 -7.023  4.627   1.00 41.97  ? 14  PRO A C   1 
ATOM   70   O O   . PRO A 1 10  ? -51.310 -8.061  4.367   1.00 41.19  ? 14  PRO A O   1 
ATOM   71   C CB  . PRO A 1 10  ? -53.615 -7.070  6.527   1.00 46.58  ? 14  PRO A CB  1 
ATOM   72   C CG  . PRO A 1 10  ? -54.769 -8.063  6.753   1.00 51.28  ? 14  PRO A CG  1 
ATOM   73   C CD  . PRO A 1 10  ? -54.737 -8.986  5.541   1.00 48.98  ? 14  PRO A CD  1 
ATOM   74   N N   . GLU A 1 11  ? -51.436 -5.805  4.693   1.00 39.71  ? 15  GLU A N   1 
ATOM   75   C CA  . GLU A 1 11  ? -50.047 -5.466  4.380   1.00 39.88  ? 15  GLU A CA  1 
ATOM   76   C C   . GLU A 1 11  ? -49.195 -6.467  5.116   1.00 35.45  ? 15  GLU A C   1 
ATOM   77   O O   . GLU A 1 11  ? -48.272 -7.028  4.532   1.00 34.85  ? 15  GLU A O   1 
ATOM   78   C CB  . GLU A 1 11  ? -49.786 -3.995  4.817   1.00 42.59  ? 15  GLU A CB  1 
ATOM   79   C CG  . GLU A 1 11  ? -48.336 -3.601  4.682   1.00 47.59  ? 15  GLU A CG  1 
ATOM   80   C CD  . GLU A 1 11  ? -48.043 -2.131  5.015   1.00 54.22  ? 15  GLU A CD  1 
ATOM   81   O OE1 . GLU A 1 11  ? -48.982 -1.340  5.168   1.00 48.08  ? 15  GLU A OE1 1 
ATOM   82   O OE2 . GLU A 1 11  ? -46.861 -1.781  5.083   1.00 64.78  ? 15  GLU A OE2 1 
ATOM   83   N N   . ALA A 1 12  ? -49.433 -6.630  6.422   1.00 40.75  ? 16  ALA A N   1 
ATOM   84   C CA  . ALA A 1 12  ? -48.569 -7.464  7.271   1.00 40.53  ? 16  ALA A CA  1 
ATOM   85   C C   . ALA A 1 12  ? -48.561 -8.934  6.784   1.00 39.65  ? 16  ALA A C   1 
ATOM   86   O O   . ALA A 1 12  ? -47.474 -9.565  6.782   1.00 40.83  ? 16  ALA A O   1 
ATOM   87   C CB  . ALA A 1 12  ? -49.048 -7.313  8.709   1.00 50.59  ? 16  ALA A CB  1 
ATOM   88   N N   . GLU A 1 13  ? -49.708 -9.489  6.372   1.00 40.25  ? 17  GLU A N   1 
ATOM   89   C CA  A GLU A 1 13  ? -49.742 -10.919 5.930   0.48 42.21  ? 17  GLU A CA  1 
ATOM   90   C CA  B GLU A 1 13  ? -49.815 -10.899 5.912   0.52 41.19  ? 17  GLU A CA  1 
ATOM   91   C C   . GLU A 1 13  ? -49.072 -10.995 4.561   1.00 40.19  ? 17  GLU A C   1 
ATOM   92   O O   . GLU A 1 13  ? -48.315 -11.973 4.335   1.00 42.39  ? 17  GLU A O   1 
ATOM   93   C CB  A GLU A 1 13  ? -51.135 -11.557 5.876   0.48 44.18  ? 17  GLU A CB  1 
ATOM   94   C CB  B GLU A 1 13  ? -51.303 -11.296 5.901   0.52 41.01  ? 17  GLU A CB  1 
ATOM   95   C CG  A GLU A 1 13  ? -51.168 -12.945 5.197   0.48 48.12  ? 17  GLU A CG  1 
ATOM   96   C CG  B GLU A 1 13  ? -52.094 -10.982 7.187   0.52 43.54  ? 17  GLU A CG  1 
ATOM   97   C CD  A GLU A 1 13  ? -50.343 -14.080 5.802   0.48 44.66  ? 17  GLU A CD  1 
ATOM   98   C CD  B GLU A 1 13  ? -51.470 -11.355 8.524   0.52 47.43  ? 17  GLU A CD  1 
ATOM   99   O OE1 A GLU A 1 13  ? -50.613 -14.474 6.940   0.48 51.55  ? 17  GLU A OE1 1 
ATOM   100  O OE1 B GLU A 1 13  ? -51.558 -10.547 9.465   0.52 47.88  ? 17  GLU A OE1 1 
ATOM   101  O OE2 A GLU A 1 13  ? -49.431 -14.569 5.140   0.48 35.78  ? 17  GLU A OE2 1 
ATOM   102  O OE2 B GLU A 1 13  ? -50.891 -12.451 8.623   0.52 46.53  ? 17  GLU A OE2 1 
ATOM   103  N N   . ILE A 1 14  ? -49.249 -9.978  3.696   1.00 40.57  ? 18  ILE A N   1 
ATOM   104  C CA  . ILE A 1 14  ? -48.517 -9.989  2.389   1.00 37.29  ? 18  ILE A CA  1 
ATOM   105  C C   . ILE A 1 14  ? -47.031 -10.051 2.702   1.00 33.83  ? 18  ILE A C   1 
ATOM   106  O O   . ILE A 1 14  ? -46.307 -10.883 2.125   1.00 34.87  ? 18  ILE A O   1 
ATOM   107  C CB  . ILE A 1 14  ? -48.850 -8.756  1.513   1.00 39.32  ? 18  ILE A CB  1 
ATOM   108  C CG1 . ILE A 1 14  ? -50.308 -8.789  1.088   1.00 38.64  ? 18  ILE A CG1 1 
ATOM   109  C CG2 . ILE A 1 14  ? -47.897 -8.661  0.332   1.00 38.36  ? 18  ILE A CG2 1 
ATOM   110  C CD1 . ILE A 1 14  ? -50.777 -7.531  0.436   1.00 41.65  ? 18  ILE A CD1 1 
ATOM   111  N N   . LYS A 1 15  ? -46.536 -9.166  3.580   1.00 35.76  ? 19  LYS A N   1 
ATOM   112  C CA  . LYS A 1 15  ? -45.077 -9.129  3.840   1.00 37.24  ? 19  LYS A CA  1 
ATOM   113  C C   . LYS A 1 15  ? -44.576 -10.475 4.415   1.00 39.42  ? 19  LYS A C   1 
ATOM   114  O O   . LYS A 1 15  ? -43.484 -10.914 4.028   1.00 38.08  ? 19  LYS A O   1 
ATOM   115  C CB  . LYS A 1 15  ? -44.773 -7.945  4.759   1.00 47.35  ? 19  LYS A CB  1 
ATOM   116  C CG  . LYS A 1 15  ? -43.369 -7.950  5.334   1.00 55.57  ? 19  LYS A CG  1 
ATOM   117  C CD  . LYS A 1 15  ? -43.088 -6.753  6.246   1.00 62.21  ? 19  LYS A CD  1 
ATOM   118  C CE  . LYS A 1 15  ? -41.606 -6.448  6.283   1.00 66.54  ? 19  LYS A CE  1 
ATOM   119  N NZ  . LYS A 1 15  ? -41.277 -5.662  7.481   1.00 74.99  ? 19  LYS A NZ  1 
ATOM   120  N N   . ALA A 1 16  ? -45.275 -11.081 5.381   1.00 37.95  ? 20  ALA A N   1 
ATOM   121  C CA  . ALA A 1 16  ? -44.875 -12.394 5.949   1.00 39.48  ? 20  ALA A CA  1 
ATOM   122  C C   . ALA A 1 16  ? -44.821 -13.447 4.820   1.00 35.79  ? 20  ALA A C   1 
ATOM   123  O O   . ALA A 1 16  ? -43.801 -14.188 4.663   1.00 39.87  ? 20  ALA A O   1 
ATOM   124  C CB  . ALA A 1 16  ? -45.839 -12.805 7.065   1.00 44.49  ? 20  ALA A CB  1 
ATOM   125  N N   . ARG A 1 17  ? -45.809 -13.424 3.931   1.00 36.83  ? 21  ARG A N   1 
ATOM   126  C CA  . ARG A 1 17  ? -45.843 -14.402 2.801   1.00 40.17  ? 21  ARG A CA  1 
ATOM   127  C C   . ARG A 1 17  ? -44.677 -14.158 1.837   1.00 39.91  ? 21  ARG A C   1 
ATOM   128  O O   . ARG A 1 17  ? -43.964 -15.139 1.386   1.00 32.96  ? 21  ARG A O   1 
ATOM   129  C CB  . ARG A 1 17  ? -47.240 -14.337 2.166   1.00 38.57  ? 21  ARG A CB  1 
ATOM   130  C CG  . ARG A 1 17  ? -47.543 -15.513 1.248   1.00 44.94  ? 21  ARG A CG  1 
ATOM   131  C CD  . ARG A 1 17  ? -47.198 -16.910 1.774   1.00 44.07  ? 21  ARG A CD  1 
ATOM   132  N NE  . ARG A 1 17  ? -47.287 -17.877 0.688   1.00 41.54  ? 21  ARG A NE  1 
ATOM   133  C CZ  . ARG A 1 17  ? -46.623 -19.015 0.623   1.00 41.93  ? 21  ARG A CZ  1 
ATOM   134  N NH1 . ARG A 1 17  ? -45.809 -19.364 1.592   1.00 44.89  ? 21  ARG A NH1 1 
ATOM   135  N NH2 . ARG A 1 17  ? -46.740 -19.800 -0.440  1.00 40.72  ? 21  ARG A NH2 1 
ATOM   136  N N   . ILE A 1 18  ? -44.380 -12.888 1.544   1.00 41.51  ? 22  ILE A N   1 
ATOM   137  C CA  . ILE A 1 18  ? -43.275 -12.604 0.584   1.00 36.95  ? 22  ILE A CA  1 
ATOM   138  C C   . ILE A 1 18  ? -41.958 -13.067 1.201   1.00 35.93  ? 22  ILE A C   1 
ATOM   139  O O   . ILE A 1 18  ? -41.125 -13.631 0.437   1.00 36.65  ? 22  ILE A O   1 
ATOM   140  C CB  . ILE A 1 18  ? -43.276 -11.125 0.128   1.00 41.79  ? 22  ILE A CB  1 
ATOM   141  C CG1 . ILE A 1 18  ? -44.489 -10.882 -0.769  1.00 39.34  ? 22  ILE A CG1 1 
ATOM   142  C CG2 . ILE A 1 18  ? -41.972 -10.783 -0.563  1.00 39.08  ? 22  ILE A CG2 1 
ATOM   143  C CD1 . ILE A 1 18  ? -44.686 -9.464  -1.162  1.00 49.11  ? 22  ILE A CD1 1 
ATOM   144  N N   . ALA A 1 19  ? -41.746 -12.899 2.519   1.00 39.18  ? 23  ALA A N   1 
ATOM   145  C CA  . ALA A 1 19  ? -40.477 -13.363 3.141   1.00 39.62  ? 23  ALA A CA  1 
ATOM   146  C C   . ALA A 1 19  ? -40.335 -14.900 2.972   1.00 40.20  ? 23  ALA A C   1 
ATOM   147  O O   . ALA A 1 19  ? -39.205 -15.403 2.686   1.00 41.16  ? 23  ALA A O   1 
ATOM   148  C CB  . ALA A 1 19  ? -40.446 -12.934 4.596   1.00 42.02  ? 23  ALA A CB  1 
ATOM   149  N N   . GLU A 1 20  ? -41.437 -15.658 3.113   1.00 44.75  ? 24  GLU A N   1 
ATOM   150  C CA  . GLU A 1 20  ? -41.432 -17.139 2.873   1.00 43.26  ? 24  GLU A CA  1 
ATOM   151  C C   . GLU A 1 20  ? -41.191 -17.439 1.381   1.00 40.65  ? 24  GLU A C   1 
ATOM   152  O O   . GLU A 1 20  ? -40.262 -18.239 1.056   1.00 38.73  ? 24  GLU A O   1 
ATOM   153  C CB  . GLU A 1 20  ? -42.731 -17.791 3.380   1.00 47.98  ? 24  GLU A CB  1 
ATOM   154  C CG  . GLU A 1 20  ? -42.727 -19.324 3.221   1.00 57.56  ? 24  GLU A CG  1 
ATOM   155  C CD  . GLU A 1 20  ? -41.500 -20.105 3.729   1.00 63.43  ? 24  GLU A CD  1 
ATOM   156  O OE1 . GLU A 1 20  ? -40.850 -19.643 4.662   1.00 60.94  ? 24  GLU A OE1 1 
ATOM   157  O OE2 . GLU A 1 20  ? -41.181 -21.183 3.186   1.00 62.74  ? 24  GLU A OE2 1 
ATOM   158  N N   . LEU A 1 21  ? -41.899 -16.778 0.453   1.00 39.98  ? 25  LEU A N   1 
ATOM   159  C CA  . LEU A 1 21  ? -41.550 -16.988 -0.993  1.00 37.30  ? 25  LEU A CA  1 
ATOM   160  C C   . LEU A 1 21  ? -40.063 -16.704 -1.209  1.00 38.60  ? 25  LEU A C   1 
ATOM   161  O O   . LEU A 1 21  ? -39.350 -17.479 -1.930  1.00 37.42  ? 25  LEU A O   1 
ATOM   162  C CB  . LEU A 1 21  ? -42.406 -16.072 -1.848  1.00 39.29  ? 25  LEU A CB  1 
ATOM   163  C CG  . LEU A 1 21  ? -43.881 -16.394 -1.896  1.00 40.15  ? 25  LEU A CG  1 
ATOM   164  C CD1 . LEU A 1 21  ? -44.573 -15.370 -2.740  1.00 42.28  ? 25  LEU A CD1 1 
ATOM   165  C CD2 . LEU A 1 21  ? -44.125 -17.801 -2.476  1.00 42.50  ? 25  LEU A CD2 1 
ATOM   166  N N   . GLY A 1 22  ? -39.533 -15.634 -0.608  1.00 38.07  ? 26  GLY A N   1 
ATOM   167  C CA  . GLY A 1 22  ? -38.110 -15.321 -0.849  1.00 38.92  ? 26  GLY A CA  1 
ATOM   168  C C   . GLY A 1 22  ? -37.154 -16.386 -0.327  1.00 43.19  ? 26  GLY A C   1 
ATOM   169  O O   . GLY A 1 22  ? -36.128 -16.664 -1.004  1.00 37.88  ? 26  GLY A O   1 
ATOM   170  N N   . ARG A 1 23  ? -37.427 -16.988 0.842   1.00 51.08  ? 27  ARG A N   1 
ATOM   171  C CA  . ARG A 1 23  ? -36.597 -18.141 1.329   1.00 50.99  ? 27  ARG A CA  1 
ATOM   172  C C   . ARG A 1 23  ? -36.727 -19.322 0.355   1.00 43.00  ? 27  ARG A C   1 
ATOM   173  O O   . ARG A 1 23  ? -35.701 -19.886 -0.026  1.00 47.62  ? 27  ARG A O   1 
ATOM   174  C CB  . ARG A 1 23  ? -37.027 -18.646 2.712   1.00 54.14  ? 27  ARG A CB  1 
ATOM   175  C CG  . ARG A 1 23  ? -36.857 -17.653 3.848   1.00 55.98  ? 27  ARG A CG  1 
ATOM   176  C CD  . ARG A 1 23  ? -37.551 -18.216 5.097   1.00 60.38  ? 27  ARG A CD  1 
ATOM   177  N NE  . ARG A 1 23  ? -37.834 -17.036 5.864   1.00 66.78  ? 27  ARG A NE  1 
ATOM   178  C CZ  . ARG A 1 23  ? -39.011 -16.590 6.273   1.00 52.67  ? 27  ARG A CZ  1 
ATOM   179  N NH1 . ARG A 1 23  ? -40.124 -17.276 6.126   1.00 54.32  ? 27  ARG A NH1 1 
ATOM   180  N NH2 . ARG A 1 23  ? -39.052 -15.448 6.927   1.00 64.93  ? 27  ARG A NH2 1 
ATOM   181  N N   . GLN A 1 24  ? -37.940 -19.655 -0.096  1.00 41.31  ? 28  GLN A N   1 
ATOM   182  C CA  . GLN A 1 24  ? -38.078 -20.789 -1.052  1.00 43.45  ? 28  GLN A CA  1 
ATOM   183  C C   . GLN A 1 24  ? -37.333 -20.489 -2.331  1.00 44.56  ? 28  GLN A C   1 
ATOM   184  O O   . GLN A 1 24  ? -36.646 -21.389 -2.863  1.00 41.62  ? 28  GLN A O   1 
ATOM   185  C CB  . GLN A 1 24  ? -39.507 -21.073 -1.485  1.00 44.77  ? 28  GLN A CB  1 
ATOM   186  C CG  . GLN A 1 24  ? -40.327 -21.669 -0.380  1.00 46.24  ? 28  GLN A CG  1 
ATOM   187  C CD  . GLN A 1 24  ? -41.786 -21.635 -0.726  1.00 53.91  ? 28  GLN A CD  1 
ATOM   188  O OE1 . GLN A 1 24  ? -42.136 -21.609 -1.897  1.00 54.68  ? 28  GLN A OE1 1 
ATOM   189  N NE2 . GLN A 1 24  ? -42.631 -21.637 0.297   1.00 57.42  ? 28  GLN A NE2 1 
ATOM   190  N N   . ILE A 1 25  ? -37.480 -19.271 -2.855  1.00 42.85  ? 29  ILE A N   1 
ATOM   191  C CA  . ILE A 1 25  ? -36.801 -18.945 -4.136  1.00 36.78  ? 29  ILE A CA  1 
ATOM   192  C C   . ILE A 1 25  ? -35.305 -19.055 -3.882  1.00 37.30  ? 29  ILE A C   1 
ATOM   193  O O   . ILE A 1 25  ? -34.611 -19.688 -4.724  1.00 40.65  ? 29  ILE A O   1 
ATOM   194  C CB  . ILE A 1 25  ? -37.227 -17.561 -4.683  1.00 40.78  ? 29  ILE A CB  1 
ATOM   195  C CG1 . ILE A 1 25  ? -38.682 -17.581 -5.150  1.00 44.95  ? 29  ILE A CG1 1 
ATOM   196  C CG2 . ILE A 1 25  ? -36.285 -17.168 -5.806  1.00 40.89  ? 29  ILE A CG2 1 
ATOM   197  C CD1 . ILE A 1 25  ? -39.347 -16.216 -5.213  1.00 48.75  ? 29  ILE A CD1 1 
ATOM   198  N N   . THR A 1 26  ? -34.814 -18.481 -2.769  1.00 42.40  ? 30  THR A N   1 
ATOM   199  C CA  . THR A 1 26  ? -33.361 -18.488 -2.414  1.00 44.50  ? 30  THR A CA  1 
ATOM   200  C C   . THR A 1 26  ? -32.840 -19.937 -2.385  1.00 48.46  ? 30  THR A C   1 
ATOM   201  O O   . THR A 1 26  ? -31.757 -20.245 -2.969  1.00 45.89  ? 30  THR A O   1 
ATOM   202  C CB  . THR A 1 26  ? -33.097 -17.822 -1.059  1.00 49.54  ? 30  THR A CB  1 
ATOM   203  O OG1 . THR A 1 26  ? -33.505 -16.455 -1.148  1.00 45.44  ? 30  THR A OG1 1 
ATOM   204  C CG2 . THR A 1 26  ? -31.638 -17.920 -0.646  1.00 48.78  ? 30  THR A CG2 1 
ATOM   205  N N   . GLU A 1 27  ? -33.583 -20.813 -1.716  1.00 48.02  ? 31  GLU A N   1 
ATOM   206  C CA  . GLU A 1 27  ? -33.221 -22.251 -1.581  1.00 53.42  ? 31  GLU A CA  1 
ATOM   207  C C   . GLU A 1 27  ? -33.125 -22.890 -2.970  1.00 52.35  ? 31  GLU A C   1 
ATOM   208  O O   . GLU A 1 27  ? -32.102 -23.552 -3.259  1.00 52.73  ? 31  GLU A O   1 
ATOM   209  C CB  . GLU A 1 27  ? -34.248 -22.961 -0.681  1.00 58.21  ? 31  GLU A CB  1 
ATOM   210  C CG  . GLU A 1 27  ? -33.887 -24.385 -0.314  1.00 68.95  ? 31  GLU A CG  1 
ATOM   211  C CD  . GLU A 1 27  ? -32.777 -24.463 0.722   1.00 79.14  ? 31  GLU A CD  1 
ATOM   212  O OE1 . GLU A 1 27  ? -32.178 -23.400 1.055   1.00 78.69  ? 31  GLU A OE1 1 
ATOM   213  O OE2 . GLU A 1 27  ? -32.510 -25.580 1.195   1.00 100.05 ? 31  GLU A OE2 1 
ATOM   214  N N   A ARG A 1 28  ? -34.152 -22.663 -3.789  0.45 46.67  ? 32  ARG A N   1 
ATOM   215  N N   B ARG A 1 28  ? -34.131 -22.732 -3.841  0.55 53.02  ? 32  ARG A N   1 
ATOM   216  C CA  A ARG A 1 28  ? -34.292 -23.264 -5.134  0.45 41.23  ? 32  ARG A CA  1 
ATOM   217  C CA  B ARG A 1 28  ? -34.098 -23.427 -5.157  0.55 51.14  ? 32  ARG A CA  1 
ATOM   218  C C   A ARG A 1 28  ? -33.072 -22.897 -5.995  0.45 43.92  ? 32  ARG A C   1 
ATOM   219  C C   B ARG A 1 28  ? -32.863 -22.966 -5.930  0.55 49.75  ? 32  ARG A C   1 
ATOM   220  O O   A ARG A 1 28  ? -32.658 -23.763 -6.767  0.45 43.56  ? 32  ARG A O   1 
ATOM   221  O O   B ARG A 1 28  ? -32.239 -23.800 -6.589  0.55 49.73  ? 32  ARG A O   1 
ATOM   222  C CB  A ARG A 1 28  ? -35.647 -22.868 -5.741  0.45 35.83  ? 32  ARG A CB  1 
ATOM   223  C CB  B ARG A 1 28  ? -35.357 -23.248 -6.021  0.55 55.22  ? 32  ARG A CB  1 
ATOM   224  C CG  A ARG A 1 28  ? -35.871 -23.361 -7.167  0.45 36.76  ? 32  ARG A CG  1 
ATOM   225  C CG  B ARG A 1 28  ? -35.644 -24.447 -6.931  0.55 63.33  ? 32  ARG A CG  1 
ATOM   226  C CD  A ARG A 1 28  ? -36.460 -24.780 -7.315  0.45 41.24  ? 32  ARG A CD  1 
ATOM   227  C CD  B ARG A 1 28  ? -35.497 -24.318 -8.458  0.55 67.19  ? 32  ARG A CD  1 
ATOM   228  N NE  A ARG A 1 28  ? -37.529 -25.077 -6.366  0.45 40.99  ? 32  ARG A NE  1 
ATOM   229  N NE  B ARG A 1 28  ? -34.131 -24.504 -8.959  0.55 69.41  ? 32  ARG A NE  1 
ATOM   230  C CZ  A ARG A 1 28  ? -38.825 -25.075 -6.640  0.45 38.06  ? 32  ARG A CZ  1 
ATOM   231  C CZ  B ARG A 1 28  ? -33.759 -24.644 -10.231 0.55 57.57  ? 32  ARG A CZ  1 
ATOM   232  N NH1 A ARG A 1 28  ? -39.281 -24.808 -7.851  0.45 38.59  ? 32  ARG A NH1 1 
ATOM   233  N NH1 B ARG A 1 28  ? -32.472 -24.753 -10.518 0.55 53.01  ? 32  ARG A NH1 1 
ATOM   234  N NH2 A ARG A 1 28  ? -39.671 -25.344 -5.677  0.45 41.92  ? 32  ARG A NH2 1 
ATOM   235  N NH2 B ARG A 1 28  ? -34.646 -24.636 -11.208 0.55 57.61  ? 32  ARG A NH2 1 
ATOM   236  N N   . TYR A 1 29  ? -32.499 -21.689 -5.882  1.00 47.62  ? 33  TYR A N   1 
ATOM   237  C CA  . TYR A 1 29  ? -31.540 -21.154 -6.893  1.00 47.89  ? 33  TYR A CA  1 
ATOM   238  C C   . TYR A 1 29  ? -30.131 -20.921 -6.328  1.00 52.60  ? 33  TYR A C   1 
ATOM   239  O O   . TYR A 1 29  ? -29.249 -20.615 -7.152  1.00 54.80  ? 33  TYR A O   1 
ATOM   240  C CB  . TYR A 1 29  ? -32.082 -19.861 -7.543  1.00 47.95  ? 33  TYR A CB  1 
ATOM   241  C CG  . TYR A 1 29  ? -33.285 -20.064 -8.432  1.00 42.11  ? 33  TYR A CG  1 
ATOM   242  C CD1 . TYR A 1 29  ? -33.180 -20.498 -9.755  1.00 43.99  ? 33  TYR A CD1 1 
ATOM   243  C CD2 . TYR A 1 29  ? -34.553 -19.871 -7.935  1.00 42.07  ? 33  TYR A CD2 1 
ATOM   244  C CE1 . TYR A 1 29  ? -34.307 -20.707 -10.543 1.00 39.40  ? 33  TYR A CE1 1 
ATOM   245  C CE2 . TYR A 1 29  ? -35.680 -20.082 -8.708  1.00 38.47  ? 33  TYR A CE2 1 
ATOM   246  C CZ  . TYR A 1 29  ? -35.563 -20.496 -10.014 1.00 37.37  ? 33  TYR A CZ  1 
ATOM   247  O OH  . TYR A 1 29  ? -36.720 -20.660 -10.728 1.00 39.85  ? 33  TYR A OH  1 
ATOM   248  N N   . LYS A 1 30  ? -29.897 -20.990 -5.016  1.00 57.27  ? 34  LYS A N   1 
ATOM   249  C CA  . LYS A 1 30  ? -28.619 -20.468 -4.446  1.00 59.36  ? 34  LYS A CA  1 
ATOM   250  C C   . LYS A 1 30  ? -27.423 -21.267 -4.983  1.00 61.04  ? 34  LYS A C   1 
ATOM   251  O O   . LYS A 1 30  ? -26.359 -20.664 -5.124  1.00 60.56  ? 34  LYS A O   1 
ATOM   252  C CB  . LYS A 1 30  ? -28.612 -20.496 -2.920  1.00 65.30  ? 34  LYS A CB  1 
ATOM   253  C CG  . LYS A 1 30  ? -28.177 -21.829 -2.335  1.00 74.08  ? 34  LYS A CG  1 
ATOM   254  C CD  . LYS A 1 30  ? -28.606 -22.077 -0.904  1.00 76.23  ? 34  LYS A CD  1 
ATOM   255  C CE  . LYS A 1 30  ? -28.499 -23.549 -0.559  1.00 82.02  ? 34  LYS A CE  1 
ATOM   256  N NZ  . LYS A 1 30  ? -29.833 -24.204 -0.566  1.00 89.61  ? 34  LYS A NZ  1 
ATOM   257  N N   . ASP A 1 31  ? -27.587 -22.557 -5.288  1.00 59.59  ? 35  ASP A N   1 
ATOM   258  C CA  . ASP A 1 31  ? -26.472 -23.456 -5.707  1.00 69.45  ? 35  ASP A CA  1 
ATOM   259  C C   . ASP A 1 31  ? -26.268 -23.444 -7.226  1.00 70.53  ? 35  ASP A C   1 
ATOM   260  O O   . ASP A 1 31  ? -25.289 -24.047 -7.666  1.00 69.14  ? 35  ASP A O   1 
ATOM   261  C CB  . ASP A 1 31  ? -26.720 -24.905 -5.277  1.00 72.52  ? 35  ASP A CB  1 
ATOM   262  C CG  . ASP A 1 31  ? -26.642 -25.112 -3.773  1.00 74.09  ? 35  ASP A CG  1 
ATOM   263  O OD1 . ASP A 1 31  ? -25.867 -24.363 -3.117  1.00 69.76  ? 35  ASP A OD1 1 
ATOM   264  O OD2 . ASP A 1 31  ? -27.370 -26.009 -3.271  1.00 77.56  ? 35  ASP A OD2 1 
ATOM   265  N N   . SER A 1 32  ? -27.162 -22.811 -7.994  1.00 64.44  ? 36  SER A N   1 
ATOM   266  C CA  . SER A 1 32  ? -27.163 -22.818 -9.483  1.00 57.51  ? 36  SER A CA  1 
ATOM   267  C C   . SER A 1 32  ? -25.795 -22.420 -10.034 1.00 50.30  ? 36  SER A C   1 
ATOM   268  O O   . SER A 1 32  ? -25.347 -23.092 -10.957 1.00 56.93  ? 36  SER A O   1 
ATOM   269  C CB  . SER A 1 32  ? -28.237 -21.910 -10.071 1.00 54.43  ? 36  SER A CB  1 
ATOM   270  O OG  . SER A 1 32  ? -28.213 -22.005 -11.489 1.00 56.90  ? 36  SER A OG  1 
ATOM   271  N N   . GLY A 1 33  ? -25.214 -21.309 -9.578  1.00 57.30  ? 37  GLY A N   1 
ATOM   272  C CA  . GLY A 1 33  ? -23.939 -20.784 -10.120 1.00 63.05  ? 37  GLY A CA  1 
ATOM   273  C C   . GLY A 1 33  ? -24.146 -19.794 -11.266 1.00 68.04  ? 37  GLY A C   1 
ATOM   274  O O   . GLY A 1 33  ? -23.475 -18.743 -11.272 1.00 83.40  ? 37  GLY A O   1 
ATOM   275  N N   . SER A 1 34  ? -25.064 -20.102 -12.186 1.00 65.30  ? 38  SER A N   1 
ATOM   276  C CA  . SER A 1 34  ? -25.441 -19.298 -13.379 1.00 57.26  ? 38  SER A CA  1 
ATOM   277  C C   . SER A 1 34  ? -25.990 -17.919 -12.979 1.00 53.85  ? 38  SER A C   1 
ATOM   278  O O   . SER A 1 34  ? -26.454 -17.753 -11.855 1.00 51.54  ? 38  SER A O   1 
ATOM   279  C CB  . SER A 1 34  ? -26.449 -20.058 -14.204 1.00 57.74  ? 38  SER A CB  1 
ATOM   280  O OG  . SER A 1 34  ? -25.858 -21.216 -14.760 1.00 66.71  ? 38  SER A OG  1 
ATOM   281  N N   . ASP A 1 35  ? -25.994 -16.952 -13.890 1.00 54.10  ? 39  ASP A N   1 
ATOM   282  C CA  . ASP A 1 35  ? -26.682 -15.658 -13.642 1.00 51.25  ? 39  ASP A CA  1 
ATOM   283  C C   . ASP A 1 35  ? -28.191 -15.895 -13.528 1.00 48.00  ? 39  ASP A C   1 
ATOM   284  O O   . ASP A 1 35  ? -28.734 -16.851 -14.108 1.00 46.54  ? 39  ASP A O   1 
ATOM   285  C CB  . ASP A 1 35  ? -26.390 -14.639 -14.736 1.00 56.21  ? 39  ASP A CB  1 
ATOM   286  C CG  . ASP A 1 35  ? -24.928 -14.261 -14.776 1.00 56.34  ? 39  ASP A CG  1 
ATOM   287  O OD1 . ASP A 1 35  ? -24.288 -14.381 -13.749 1.00 67.83  ? 39  ASP A OD1 1 
ATOM   288  O OD2 . ASP A 1 35  ? -24.449 -13.895 -15.841 1.00 58.53  ? 39  ASP A OD2 1 
ATOM   289  N N   . MET A 1 36  ? -28.850 -15.021 -12.786 1.00 49.71  ? 40  MET A N   1 
ATOM   290  C CA  . MET A 1 36  ? -30.302 -15.097 -12.533 1.00 50.42  ? 40  MET A CA  1 
ATOM   291  C C   . MET A 1 36  ? -30.957 -13.761 -12.939 1.00 46.61  ? 40  MET A C   1 
ATOM   292  O O   . MET A 1 36  ? -30.383 -12.719 -12.648 1.00 41.11  ? 40  MET A O   1 
ATOM   293  C CB  . MET A 1 36  ? -30.510 -15.366 -11.045 1.00 45.72  ? 40  MET A CB  1 
ATOM   294  C CG  . MET A 1 36  ? -31.934 -15.591 -10.690 1.00 47.01  ? 40  MET A CG  1 
ATOM   295  S SD  . MET A 1 36  ? -32.087 -16.123 -8.959  1.00 55.13  ? 40  MET A SD  1 
ATOM   296  C CE  . MET A 1 36  ? -33.861 -16.329 -8.873  1.00 55.91  ? 40  MET A CE  1 
ATOM   297  N N   . VAL A 1 37  ? -32.165 -13.796 -13.485 1.00 42.66  ? 41  VAL A N   1 
ATOM   298  C CA  . VAL A 1 37  ? -32.978 -12.576 -13.695 1.00 43.38  ? 41  VAL A CA  1 
ATOM   299  C C   . VAL A 1 37  ? -34.409 -12.831 -13.243 1.00 42.65  ? 41  VAL A C   1 
ATOM   300  O O   . VAL A 1 37  ? -35.001 -13.899 -13.566 1.00 37.77  ? 41  VAL A O   1 
ATOM   301  C CB  . VAL A 1 37  ? -32.852 -12.116 -15.158 1.00 44.87  ? 41  VAL A CB  1 
ATOM   302  C CG1 . VAL A 1 37  ? -33.096 -13.240 -16.111 1.00 55.74  ? 41  VAL A CG1 1 
ATOM   303  C CG2 . VAL A 1 37  ? -33.748 -10.938 -15.472 1.00 42.49  ? 41  VAL A CG2 1 
ATOM   304  N N   . LEU A 1 38  ? -34.924 -11.866 -12.496 1.00 37.00  ? 42  LEU A N   1 
ATOM   305  C CA  . LEU A 1 38  ? -36.361 -11.708 -12.215 1.00 37.80  ? 42  LEU A CA  1 
ATOM   306  C C   . LEU A 1 38  ? -36.946 -10.759 -13.258 1.00 41.76  ? 42  LEU A C   1 
ATOM   307  O O   . LEU A 1 38  ? -36.406 -9.635  -13.478 1.00 40.72  ? 42  LEU A O   1 
ATOM   308  C CB  . LEU A 1 38  ? -36.588 -11.191 -10.795 1.00 36.81  ? 42  LEU A CB  1 
ATOM   309  C CG  . LEU A 1 38  ? -36.685 -12.242 -9.686  1.00 36.96  ? 42  LEU A CG  1 
ATOM   310  C CD1 . LEU A 1 38  ? -35.463 -13.154 -9.656  1.00 40.48  ? 42  LEU A CD1 1 
ATOM   311  C CD2 . LEU A 1 38  ? -36.834 -11.550 -8.348  1.00 39.26  ? 42  LEU A CD2 1 
ATOM   312  N N   . VAL A 1 39  ? -38.020 -11.213 -13.886 1.00 36.22  ? 43  VAL A N   1 
ATOM   313  C CA  . VAL A 1 39  ? -38.683 -10.512 -14.997 1.00 37.97  ? 43  VAL A CA  1 
ATOM   314  C C   . VAL A 1 39  ? -40.093 -10.228 -14.552 1.00 38.39  ? 43  VAL A C   1 
ATOM   315  O O   . VAL A 1 39  ? -40.858 -11.175 -14.491 1.00 37.73  ? 43  VAL A O   1 
ATOM   316  C CB  . VAL A 1 39  ? -38.681 -11.359 -16.278 1.00 38.35  ? 43  VAL A CB  1 
ATOM   317  C CG1 . VAL A 1 39  ? -39.610 -10.751 -17.312 1.00 40.25  ? 43  VAL A CG1 1 
ATOM   318  C CG2 . VAL A 1 39  ? -37.279 -11.566 -16.809 1.00 37.93  ? 43  VAL A CG2 1 
ATOM   319  N N   . GLY A 1 40  ? -40.432 -8.952  -14.368 1.00 36.42  ? 44  GLY A N   1 
ATOM   320  C CA  . GLY A 1 40  ? -41.803 -8.578  -14.046 1.00 35.18  ? 44  GLY A CA  1 
ATOM   321  C C   . GLY A 1 40  ? -42.565 -8.241  -15.296 1.00 39.08  ? 44  GLY A C   1 
ATOM   322  O O   . GLY A 1 40  ? -42.001 -7.563  -16.198 1.00 40.16  ? 44  GLY A O   1 
ATOM   323  N N   . LEU A 1 41  ? -43.844 -8.572  -15.301 1.00 37.71  ? 45  LEU A N   1 
ATOM   324  C CA  . LEU A 1 41  ? -44.799 -8.078  -16.313 1.00 38.19  ? 45  LEU A CA  1 
ATOM   325  C C   . LEU A 1 41  ? -45.445 -6.801  -15.782 1.00 42.97  ? 45  LEU A C   1 
ATOM   326  O O   . LEU A 1 41  ? -46.110 -6.861  -14.736 1.00 41.17  ? 45  LEU A O   1 
ATOM   327  C CB  . LEU A 1 41  ? -45.846 -9.151  -16.591 1.00 40.41  ? 45  LEU A CB  1 
ATOM   328  C CG  . LEU A 1 41  ? -45.243 -10.504 -16.993 1.00 46.20  ? 45  LEU A CG  1 
ATOM   329  C CD1 . LEU A 1 41  ? -46.340 -11.453 -17.430 1.00 45.65  ? 45  LEU A CD1 1 
ATOM   330  C CD2 . LEU A 1 41  ? -44.221 -10.360 -18.091 1.00 49.57  ? 45  LEU A CD2 1 
ATOM   331  N N   . LEU A 1 42  ? -45.292 -5.707  -16.524 1.00 39.42  ? 46  LEU A N   1 
ATOM   332  C CA  . LEU A 1 42  ? -45.807 -4.360  -16.175 1.00 40.32  ? 46  LEU A CA  1 
ATOM   333  C C   . LEU A 1 42  ? -47.197 -4.219  -16.750 1.00 40.02  ? 46  LEU A C   1 
ATOM   334  O O   . LEU A 1 42  ? -47.469 -4.806  -17.795 1.00 44.25  ? 46  LEU A O   1 
ATOM   335  C CB  . LEU A 1 42  ? -44.843 -3.305  -16.750 1.00 40.32  ? 46  LEU A CB  1 
ATOM   336  C CG  . LEU A 1 42  ? -43.506 -3.231  -16.021 1.00 44.75  ? 46  LEU A CG  1 
ATOM   337  C CD1 . LEU A 1 42  ? -42.636 -2.137  -16.594 1.00 52.42  ? 46  LEU A CD1 1 
ATOM   338  C CD2 . LEU A 1 42  ? -43.690 -3.037  -14.526 1.00 47.26  ? 46  LEU A CD2 1 
ATOM   339  N N   . ARG A 1 43  ? -48.053 -3.425  -16.092 1.00 36.56  ? 47  ARG A N   1 
ATOM   340  C CA  . ARG A 1 43  ? -47.714 -2.656  -14.903 1.00 41.54  ? 47  ARG A CA  1 
ATOM   341  C C   . ARG A 1 43  ? -47.937 -3.419  -13.593 1.00 46.27  ? 47  ARG A C   1 
ATOM   342  O O   . ARG A 1 43  ? -47.372 -3.012  -12.571 1.00 39.71  ? 47  ARG A O   1 
ATOM   343  C CB  . ARG A 1 43  ? -48.576 -1.392  -14.862 1.00 43.09  ? 47  ARG A CB  1 
ATOM   344  C CG  . ARG A 1 43  ? -48.048 -0.327  -15.823 1.00 44.38  ? 47  ARG A CG  1 
ATOM   345  C CD  . ARG A 1 43  ? -48.897 0.909   -15.755 1.00 42.53  ? 47  ARG A CD  1 
ATOM   346  N NE  . ARG A 1 43  ? -50.094 0.736   -16.537 1.00 40.73  ? 47  ARG A NE  1 
ATOM   347  C CZ  . ARG A 1 43  ? -51.122 1.539   -16.486 1.00 42.07  ? 47  ARG A CZ  1 
ATOM   348  N NH1 . ARG A 1 43  ? -51.156 2.569   -15.650 1.00 45.87  ? 47  ARG A NH1 1 
ATOM   349  N NH2 . ARG A 1 43  ? -52.113 1.335   -17.318 1.00 40.88  ? 47  ARG A NH2 1 
ATOM   350  N N   . GLY A 1 44  ? -48.787 -4.447  -13.613 1.00 41.40  ? 48  GLY A N   1 
ATOM   351  C CA  . GLY A 1 44  ? -49.238 -5.209  -12.441 1.00 42.51  ? 48  GLY A CA  1 
ATOM   352  C C   . GLY A 1 44  ? -48.149 -5.616  -11.452 1.00 39.96  ? 48  GLY A C   1 
ATOM   353  O O   . GLY A 1 44  ? -48.441 -5.621  -10.242 1.00 44.01  ? 48  GLY A O   1 
ATOM   354  N N   . SER A 1 45  ? -46.951 -5.964  -11.902 1.00 36.95  ? 49  SER A N   1 
ATOM   355  C CA  . SER A 1 45  ? -45.976 -6.662  -11.042 1.00 37.22  ? 49  SER A CA  1 
ATOM   356  C C   . SER A 1 45  ? -45.066 -5.681  -10.302 1.00 41.68  ? 49  SER A C   1 
ATOM   357  O O   . SER A 1 45  ? -44.204 -6.179  -9.563  1.00 36.54  ? 49  SER A O   1 
ATOM   358  C CB  . SER A 1 45  ? -45.154 -7.597  -11.867 1.00 46.53  ? 49  SER A CB  1 
ATOM   359  O OG  . SER A 1 45  ? -44.120 -6.865  -12.569 1.00 55.33  ? 49  SER A OG  1 
ATOM   360  N N   . PHE A 1 46  ? -45.152 -4.358  -10.524 1.00 36.65  ? 50  PHE A N   1 
ATOM   361  C CA  . PHE A 1 46  ? -44.035 -3.472  -10.084 1.00 40.00  ? 50  PHE A CA  1 
ATOM   362  C C   . PHE A 1 46  ? -43.865 -3.526  -8.554  1.00 32.55  ? 50  PHE A C   1 
ATOM   363  O O   . PHE A 1 46  ? -42.698 -3.588  -8.099  1.00 35.17  ? 50  PHE A O   1 
ATOM   364  C CB  . PHE A 1 46  ? -44.240 -2.034  -10.561 1.00 38.46  ? 50  PHE A CB  1 
ATOM   365  C CG  . PHE A 1 46  ? -45.218 -1.250  -9.741  1.00 36.99  ? 50  PHE A CG  1 
ATOM   366  C CD1 . PHE A 1 46  ? -46.560 -1.300  -10.005 1.00 39.39  ? 50  PHE A CD1 1 
ATOM   367  C CD2 . PHE A 1 46  ? -44.788 -0.457  -8.692  1.00 35.68  ? 50  PHE A CD2 1 
ATOM   368  C CE1 . PHE A 1 46  ? -47.462 -0.559  -9.265  1.00 42.17  ? 50  PHE A CE1 1 
ATOM   369  C CE2 . PHE A 1 46  ? -45.688 0.315   -7.984  1.00 35.94  ? 50  PHE A CE2 1 
ATOM   370  C CZ  . PHE A 1 46  ? -47.023 0.257   -8.251  1.00 39.44  ? 50  PHE A CZ  1 
ATOM   371  N N   . MET A 1 47  ? -44.970 -3.492  -7.808  1.00 33.78  ? 51  MET A N   1 
ATOM   372  C CA  . MET A 1 47  ? -44.959 -3.492  -6.311  1.00 35.00  ? 51  MET A CA  1 
ATOM   373  C C   . MET A 1 47  ? -44.527 -4.862  -5.776  1.00 38.48  ? 51  MET A C   1 
ATOM   374  O O   . MET A 1 47  ? -43.567 -4.918  -5.002  1.00 39.61  ? 51  MET A O   1 
ATOM   375  C CB  . MET A 1 47  ? -46.324 -3.138  -5.738  1.00 37.91  ? 51  MET A CB  1 
ATOM   376  C CG  . MET A 1 47  ? -46.217 -2.745  -4.239  1.00 34.24  ? 51  MET A CG  1 
ATOM   377  S SD  . MET A 1 47  ? -47.706 -2.143  -3.563  1.00 39.35  ? 51  MET A SD  1 
ATOM   378  C CE  . MET A 1 47  ? -47.862 -0.524  -4.321  1.00 41.53  ? 51  MET A CE  1 
ATOM   379  N N   . PHE A 1 48  ? -45.138 -5.954  -6.267  1.00 39.37  ? 52  PHE A N   1 
ATOM   380  C CA  . PHE A 1 48  ? -44.708 -7.340  -5.926  1.00 35.33  ? 52  PHE A CA  1 
ATOM   381  C C   . PHE A 1 48  ? -43.228 -7.498  -6.194  1.00 31.51  ? 52  PHE A C   1 
ATOM   382  O O   . PHE A 1 48  ? -42.466 -7.992  -5.300  1.00 34.79  ? 52  PHE A O   1 
ATOM   383  C CB  . PHE A 1 48  ? -45.607 -8.370  -6.626  1.00 36.56  ? 52  PHE A CB  1 
ATOM   384  C CG  . PHE A 1 48  ? -45.343 -9.799  -6.265  1.00 39.33  ? 52  PHE A CG  1 
ATOM   385  C CD1 . PHE A 1 48  ? -45.087 -10.169 -4.946  1.00 40.55  ? 52  PHE A CD1 1 
ATOM   386  C CD2 . PHE A 1 48  ? -45.386 -10.788 -7.240  1.00 41.50  ? 52  PHE A CD2 1 
ATOM   387  C CE1 . PHE A 1 48  ? -44.844 -11.499 -4.625  1.00 44.25  ? 52  PHE A CE1 1 
ATOM   388  C CE2 . PHE A 1 48  ? -45.096 -12.105 -6.914  1.00 42.60  ? 52  PHE A CE2 1 
ATOM   389  C CZ  . PHE A 1 48  ? -44.815 -12.457 -5.614  1.00 37.42  ? 52  PHE A CZ  1 
ATOM   390  N N   . MET A 1 49  ? -42.751 -7.050  -7.352  1.00 31.52  ? 53  MET A N   1 
ATOM   391  C CA  . MET A 1 49  ? -41.332 -7.259  -7.693  1.00 33.11  ? 53  MET A CA  1 
ATOM   392  C C   . MET A 1 49  ? -40.417 -6.527  -6.704  1.00 33.04  ? 53  MET A C   1 
ATOM   393  O O   . MET A 1 49  ? -39.404 -7.095  -6.227  1.00 35.51  ? 53  MET A O   1 
ATOM   394  C CB  . MET A 1 49  ? -41.083 -6.759  -9.119  1.00 38.97  ? 53  MET A CB  1 
ATOM   395  C CG  . MET A 1 49  ? -39.639 -6.741  -9.490  1.00 40.57  ? 53  MET A CG  1 
ATOM   396  S SD  . MET A 1 49  ? -38.935 -8.423  -9.659  1.00 41.22  ? 53  MET A SD  1 
ATOM   397  C CE  . MET A 1 49  ? -39.407 -8.676  -11.370 1.00 37.38  ? 53  MET A CE  1 
ATOM   398  N N   . ALA A 1 50  ? -40.727 -5.275  -6.403  1.00 32.94  ? 54  ALA A N   1 
ATOM   399  C CA  . ALA A 1 50  ? -39.930 -4.488  -5.423  1.00 35.86  ? 54  ALA A CA  1 
ATOM   400  C C   . ALA A 1 50  ? -39.805 -5.254  -4.093  1.00 32.36  ? 54  ALA A C   1 
ATOM   401  O O   . ALA A 1 50  ? -38.665 -5.331  -3.564  1.00 37.44  ? 54  ALA A O   1 
ATOM   402  C CB  . ALA A 1 50  ? -40.601 -3.150  -5.216  1.00 34.89  ? 54  ALA A CB  1 
ATOM   403  N N   . ASP A 1 51  ? -40.923 -5.766  -3.541  1.00 35.52  ? 55  ASP A N   1 
ATOM   404  C CA  . ASP A 1 51  ? -40.865 -6.436  -2.199  1.00 35.67  ? 55  ASP A CA  1 
ATOM   405  C C   . ASP A 1 51  ? -40.154 -7.776  -2.357  1.00 34.27  ? 55  ASP A C   1 
ATOM   406  O O   . ASP A 1 51  ? -39.268 -8.073  -1.523  1.00 36.29  ? 55  ASP A O   1 
ATOM   407  C CB  . ASP A 1 51  ? -42.237 -6.526  -1.546  1.00 32.64  ? 55  ASP A CB  1 
ATOM   408  C CG  . ASP A 1 51  ? -42.738 -5.163  -1.190  1.00 35.07  ? 55  ASP A CG  1 
ATOM   409  O OD1 . ASP A 1 51  ? -41.939 -4.160  -1.341  1.00 36.50  ? 55  ASP A OD1 1 
ATOM   410  O OD2 . ASP A 1 51  ? -43.896 -5.078  -0.867  1.00 34.60  ? 55  ASP A OD2 1 
ATOM   411  N N   . LEU A 1 52  ? -40.456 -8.503  -3.442  1.00 38.82  ? 56  LEU A N   1 
ATOM   412  C CA  . LEU A 1 52  ? -39.958 -9.893  -3.609  1.00 35.60  ? 56  LEU A CA  1 
ATOM   413  C C   . LEU A 1 52  ? -38.446 -9.876  -3.815  1.00 38.45  ? 56  LEU A C   1 
ATOM   414  O O   . LEU A 1 52  ? -37.730 -10.673 -3.134  1.00 33.39  ? 56  LEU A O   1 
ATOM   415  C CB  . LEU A 1 52  ? -40.660 -10.578 -4.777  1.00 38.97  ? 56  LEU A CB  1 
ATOM   416  C CG  . LEU A 1 52  ? -40.220 -12.021 -5.022  1.00 38.76  ? 56  LEU A CG  1 
ATOM   417  C CD1 . LEU A 1 52  ? -40.637 -12.858 -3.802  1.00 39.76  ? 56  LEU A CD1 1 
ATOM   418  C CD2 . LEU A 1 52  ? -40.823 -12.608 -6.323  1.00 39.86  ? 56  LEU A CD2 1 
ATOM   419  N N   . CYS A 1 53  ? -37.933 -9.026  -4.721  1.00 39.70  ? 57  CYS A N   1 
ATOM   420  C CA  . CYS A 1 53  ? -36.485 -9.047  -5.053  1.00 35.87  ? 57  CYS A CA  1 
ATOM   421  C C   . CYS A 1 53  ? -35.660 -8.738  -3.783  1.00 37.05  ? 57  CYS A C   1 
ATOM   422  O O   . CYS A 1 53  ? -34.516 -9.261  -3.649  1.00 40.62  ? 57  CYS A O   1 
ATOM   423  C CB  . CYS A 1 53  ? -36.136 -8.159  -6.250  1.00 42.46  ? 57  CYS A CB  1 
ATOM   424  S SG  . CYS A 1 53  ? -36.113 -6.378  -5.884  1.00 39.35  ? 57  CYS A SG  1 
ATOM   425  N N   . ARG A 1 54  ? -36.215 -7.958  -2.853  1.00 37.90  ? 58  ARG A N   1 
ATOM   426  C CA  . ARG A 1 54  ? -35.477 -7.585  -1.620  1.00 45.03  ? 58  ARG A CA  1 
ATOM   427  C C   . ARG A 1 54  ? -35.395 -8.837  -0.722  1.00 48.26  ? 58  ARG A C   1 
ATOM   428  O O   . ARG A 1 54  ? -34.565 -8.835  0.175   1.00 43.25  ? 58  ARG A O   1 
ATOM   429  C CB  . ARG A 1 54  ? -36.084 -6.341  -0.941  1.00 38.98  ? 58  ARG A CB  1 
ATOM   430  C CG  . ARG A 1 54  ? -35.722 -5.023  -1.613  1.00 42.01  ? 58  ARG A CG  1 
ATOM   431  C CD  . ARG A 1 54  ? -36.393 -3.865  -0.916  1.00 36.73  ? 58  ARG A CD  1 
ATOM   432  N NE  . ARG A 1 54  ? -37.771 -3.701  -1.333  1.00 37.88  ? 58  ARG A NE  1 
ATOM   433  C CZ  . ARG A 1 54  ? -38.468 -2.615  -1.142  1.00 38.25  ? 58  ARG A CZ  1 
ATOM   434  N NH1 . ARG A 1 54  ? -37.896 -1.607  -0.510  1.00 43.34  ? 58  ARG A NH1 1 
ATOM   435  N NH2 . ARG A 1 54  ? -39.701 -2.497  -1.619  1.00 39.92  ? 58  ARG A NH2 1 
ATOM   436  N N   . GLU A 1 55  ? -36.204 -9.876  -0.944  1.00 45.92  ? 59  GLU A N   1 
ATOM   437  C CA  . GLU A 1 55  ? -36.172 -11.078 -0.072  1.00 45.00  ? 59  GLU A CA  1 
ATOM   438  C C   . GLU A 1 55  ? -35.415 -12.217 -0.745  1.00 46.99  ? 59  GLU A C   1 
ATOM   439  O O   . GLU A 1 55  ? -35.430 -13.330 -0.187  1.00 52.75  ? 59  GLU A O   1 
ATOM   440  C CB  . GLU A 1 55  ? -37.595 -11.498 0.301   1.00 44.41  ? 59  GLU A CB  1 
ATOM   441  C CG  . GLU A 1 55  ? -38.345 -10.464 1.109   1.00 45.53  ? 59  GLU A CG  1 
ATOM   442  C CD  . GLU A 1 55  ? -37.681 -10.209 2.463   1.00 52.95  ? 59  GLU A CD  1 
ATOM   443  O OE1 . GLU A 1 55  ? -37.136 -11.169 3.030   1.00 51.10  ? 59  GLU A OE1 1 
ATOM   444  O OE2 . GLU A 1 55  ? -37.646 -9.052  2.906   1.00 53.55  ? 59  GLU A OE2 1 
ATOM   445  N N   . VAL A 1 56  ? -34.864 -12.013 -1.936  1.00 42.07  ? 60  VAL A N   1 
ATOM   446  C CA  . VAL A 1 56  ? -34.198 -13.102 -2.695  1.00 40.04  ? 60  VAL A CA  1 
ATOM   447  C C   . VAL A 1 56  ? -32.685 -12.926 -2.491  1.00 51.96  ? 60  VAL A C   1 
ATOM   448  O O   . VAL A 1 56  ? -32.090 -11.977 -3.053  1.00 50.64  ? 60  VAL A O   1 
ATOM   449  C CB  . VAL A 1 56  ? -34.630 -13.171 -4.179  1.00 40.64  ? 60  VAL A CB  1 
ATOM   450  C CG1 . VAL A 1 56  ? -33.770 -14.139 -4.976  1.00 43.10  ? 60  VAL A CG1 1 
ATOM   451  C CG2 . VAL A 1 56  ? -36.104 -13.548 -4.372  1.00 42.38  ? 60  VAL A CG2 1 
ATOM   452  N N   . GLN A 1 57  ? -32.075 -13.801 -1.691  1.00 45.15  ? 61  GLN A N   1 
ATOM   453  C CA  . GLN A 1 57  ? -30.659 -13.626 -1.256  1.00 55.60  ? 61  GLN A CA  1 
ATOM   454  C C   . GLN A 1 57  ? -29.802 -14.421 -2.227  1.00 55.75  ? 61  GLN A C   1 
ATOM   455  O O   . GLN A 1 57  ? -29.035 -15.256 -1.788  1.00 66.04  ? 61  GLN A O   1 
ATOM   456  C CB  . GLN A 1 57  ? -30.419 -14.041 0.200   1.00 51.24  ? 61  GLN A CB  1 
ATOM   457  C CG  . GLN A 1 57  ? -31.555 -13.657 1.141   1.00 55.97  ? 61  GLN A CG  1 
ATOM   458  C CD  . GLN A 1 57  ? -31.358 -12.291 1.728   1.00 68.03  ? 61  GLN A CD  1 
ATOM   459  O OE1 . GLN A 1 57  ? -30.665 -11.438 1.166   1.00 67.95  ? 61  GLN A OE1 1 
ATOM   460  N NE2 . GLN A 1 57  ? -31.941 -12.099 2.896   1.00 77.58  ? 61  GLN A NE2 1 
ATOM   461  N N   . VAL A 1 58  ? -30.064 -14.250 -3.511  1.00 55.22  ? 62  VAL A N   1 
ATOM   462  C CA  . VAL A 1 58  ? -29.199 -14.719 -4.616  1.00 48.91  ? 62  VAL A CA  1 
ATOM   463  C C   . VAL A 1 58  ? -28.941 -13.482 -5.473  1.00 50.94  ? 62  VAL A C   1 
ATOM   464  O O   . VAL A 1 58  ? -29.915 -12.743 -5.736  1.00 47.93  ? 62  VAL A O   1 
ATOM   465  C CB  . VAL A 1 58  ? -29.883 -15.836 -5.425  1.00 54.80  ? 62  VAL A CB  1 
ATOM   466  C CG1 . VAL A 1 58  ? -28.973 -16.353 -6.527  1.00 57.47  ? 62  VAL A CG1 1 
ATOM   467  C CG2 . VAL A 1 58  ? -30.374 -16.977 -4.541  1.00 58.02  ? 62  VAL A CG2 1 
ATOM   468  N N   . SER A 1 59  ? -27.698 -13.283 -5.899  1.00 51.38  ? 63  SER A N   1 
ATOM   469  C CA  . SER A 1 59  ? -27.297 -12.171 -6.782  1.00 54.27  ? 63  SER A CA  1 
ATOM   470  C C   . SER A 1 59  ? -28.155 -12.272 -8.055  1.00 52.43  ? 63  SER A C   1 
ATOM   471  O O   . SER A 1 59  ? -28.268 -13.350 -8.618  1.00 47.22  ? 63  SER A O   1 
ATOM   472  C CB  . SER A 1 59  ? -25.815 -12.241 -7.034  1.00 52.32  ? 63  SER A CB  1 
ATOM   473  O OG  . SER A 1 59  ? -25.371 -11.037 -7.619  1.00 62.49  ? 63  SER A OG  1 
ATOM   474  N N   . HIS A 1 60  ? -28.889 -11.241 -8.446  1.00 47.20  ? 64  HIS A N   1 
ATOM   475  C CA  . HIS A 1 60  ? -29.711 -11.339 -9.683  1.00 43.83  ? 64  HIS A CA  1 
ATOM   476  C C   . HIS A 1 60  ? -29.879 -9.971  -10.341 1.00 47.19  ? 64  HIS A C   1 
ATOM   477  O O   . HIS A 1 60  ? -29.615 -8.967  -9.677  1.00 44.22  ? 64  HIS A O   1 
ATOM   478  C CB  . HIS A 1 60  ? -31.076 -11.978 -9.372  1.00 44.76  ? 64  HIS A CB  1 
ATOM   479  C CG  . HIS A 1 60  ? -31.945 -11.222 -8.433  1.00 37.16  ? 64  HIS A CG  1 
ATOM   480  N ND1 . HIS A 1 60  ? -31.783 -11.272 -7.081  1.00 37.62  ? 64  HIS A ND1 1 
ATOM   481  C CD2 . HIS A 1 60  ? -33.007 -10.414 -8.653  1.00 39.35  ? 64  HIS A CD2 1 
ATOM   482  C CE1 . HIS A 1 60  ? -32.707 -10.538 -6.500  1.00 37.47  ? 64  HIS A CE1 1 
ATOM   483  N NE2 . HIS A 1 60  ? -33.475 -10.002 -7.438  1.00 36.17  ? 64  HIS A NE2 1 
ATOM   484  N N   . GLU A 1 61  ? -30.347 -9.962  -11.586 1.00 47.62  ? 65  GLU A N   1 
ATOM   485  C CA  . GLU A 1 61  ? -30.812 -8.757  -12.311 1.00 47.57  ? 65  GLU A CA  1 
ATOM   486  C C   . GLU A 1 61  ? -32.332 -8.678  -12.166 1.00 44.02  ? 65  GLU A C   1 
ATOM   487  O O   . GLU A 1 61  ? -33.005 -9.743  -12.018 1.00 40.09  ? 65  GLU A O   1 
ATOM   488  C CB  . GLU A 1 61  ? -30.449 -8.832  -13.797 1.00 56.32  ? 65  GLU A CB  1 
ATOM   489  C CG  . GLU A 1 61  ? -28.995 -9.210  -14.120 1.00 77.10  ? 65  GLU A CG  1 
ATOM   490  C CD  . GLU A 1 61  ? -28.749 -9.672  -15.565 1.00 82.38  ? 65  GLU A CD  1 
ATOM   491  O OE1 . GLU A 1 61  ? -28.509 -10.876 -15.756 1.00 84.21  ? 65  GLU A OE1 1 
ATOM   492  O OE2 . GLU A 1 61  ? -28.840 -8.837  -16.511 1.00 90.55  ? 65  GLU A OE2 1 
ATOM   493  N N   . VAL A 1 62  ? -32.876 -7.475  -12.268 1.00 37.62  ? 66  VAL A N   1 
ATOM   494  C CA  . VAL A 1 62  ? -34.340 -7.223  -12.349 1.00 40.20  ? 66  VAL A CA  1 
ATOM   495  C C   . VAL A 1 62  ? -34.612 -6.584  -13.710 1.00 41.13  ? 66  VAL A C   1 
ATOM   496  O O   . VAL A 1 62  ? -33.914 -5.568  -14.033 1.00 42.84  ? 66  VAL A O   1 
ATOM   497  C CB  . VAL A 1 62  ? -34.783 -6.309  -11.181 1.00 38.01  ? 66  VAL A CB  1 
ATOM   498  C CG1 . VAL A 1 62  ? -36.234 -5.877  -11.276 1.00 40.53  ? 66  VAL A CG1 1 
ATOM   499  C CG2 . VAL A 1 62  ? -34.545 -6.914  -9.813  1.00 38.84  ? 66  VAL A CG2 1 
ATOM   500  N N   . ASP A 1 63  ? -35.591 -7.092  -14.461 1.00 38.99  ? 67  ASP A N   1 
ATOM   501  C CA  . ASP A 1 63  ? -35.961 -6.581  -15.808 1.00 38.93  ? 67  ASP A CA  1 
ATOM   502  C C   . ASP A 1 63  ? -37.472 -6.661  -15.899 1.00 41.39  ? 67  ASP A C   1 
ATOM   503  O O   . ASP A 1 63  ? -38.071 -7.203  -14.973 1.00 36.63  ? 67  ASP A O   1 
ATOM   504  C CB  . ASP A 1 63  ? -35.265 -7.365  -16.927 1.00 45.16  ? 67  ASP A CB  1 
ATOM   505  C CG  . ASP A 1 63  ? -34.988 -6.607  -18.230 1.00 46.09  ? 67  ASP A CG  1 
ATOM   506  O OD1 . ASP A 1 63  ? -35.600 -5.527  -18.477 1.00 46.92  ? 67  ASP A OD1 1 
ATOM   507  O OD2 . ASP A 1 63  ? -34.184 -7.144  -19.004 1.00 47.13  ? 67  ASP A OD2 1 
ATOM   508  N N   . PHE A 1 64  ? -38.050 -6.057  -16.927 1.00 38.90  ? 68  PHE A N   1 
ATOM   509  C CA  . PHE A 1 64  ? -39.511 -5.922  -17.084 1.00 37.91  ? 68  PHE A CA  1 
ATOM   510  C C   . PHE A 1 64  ? -39.882 -6.149  -18.541 1.00 39.43  ? 68  PHE A C   1 
ATOM   511  O O   . PHE A 1 64  ? -39.109 -5.770  -19.428 1.00 36.88  ? 68  PHE A O   1 
ATOM   512  C CB  . PHE A 1 64  ? -40.004 -4.563  -16.593 1.00 41.97  ? 68  PHE A CB  1 
ATOM   513  C CG  . PHE A 1 64  ? -39.844 -4.331  -15.111 1.00 44.33  ? 68  PHE A CG  1 
ATOM   514  C CD1 . PHE A 1 64  ? -40.784 -4.812  -14.215 1.00 40.91  ? 68  PHE A CD1 1 
ATOM   515  C CD2 . PHE A 1 64  ? -38.753 -3.641  -14.623 1.00 46.90  ? 68  PHE A CD2 1 
ATOM   516  C CE1 . PHE A 1 64  ? -40.648 -4.604  -12.850 1.00 43.61  ? 68  PHE A CE1 1 
ATOM   517  C CE2 . PHE A 1 64  ? -38.610 -3.446  -13.256 1.00 44.47  ? 68  PHE A CE2 1 
ATOM   518  C CZ  . PHE A 1 64  ? -39.557 -3.920  -12.376 1.00 46.73  ? 68  PHE A CZ  1 
ATOM   519  N N   . MET A 1 65  ? -41.056 -6.749  -18.777 1.00 39.44  ? 69  MET A N   1 
ATOM   520  C CA  . MET A 1 65  ? -41.701 -6.717  -20.106 1.00 42.08  ? 69  MET A CA  1 
ATOM   521  C C   . MET A 1 65  ? -43.067 -6.110  -19.930 1.00 40.81  ? 69  MET A C   1 
ATOM   522  O O   . MET A 1 65  ? -43.638 -6.218  -18.831 1.00 39.21  ? 69  MET A O   1 
ATOM   523  C CB  . MET A 1 65  ? -41.944 -8.074  -20.779 1.00 45.15  ? 69  MET A CB  1 
ATOM   524  C CG  . MET A 1 65  ? -41.020 -9.129  -20.343 1.00 54.12  ? 69  MET A CG  1 
ATOM   525  S SD  . MET A 1 65  ? -40.955 -10.633 -21.382 1.00 56.91  ? 69  MET A SD  1 
ATOM   526  C CE  . MET A 1 65  ? -42.072 -10.235 -22.725 1.00 45.00  ? 69  MET A CE  1 
ATOM   527  N N   . THR A 1 66  ? -43.585 -5.566  -21.022 1.00 36.83  ? 70  THR A N   1 
ATOM   528  C CA  . THR A 1 66  ? -45.029 -5.237  -21.163 1.00 39.01  ? 70  THR A CA  1 
ATOM   529  C C   . THR A 1 66  ? -45.578 -6.048  -22.330 1.00 45.38  ? 70  THR A C   1 
ATOM   530  O O   . THR A 1 66  ? -45.051 -5.920  -23.478 1.00 42.48  ? 70  THR A O   1 
ATOM   531  C CB  . THR A 1 66  ? -45.278 -3.737  -21.330 1.00 40.73  ? 70  THR A CB  1 
ATOM   532  O OG1 . THR A 1 66  ? -44.489 -3.058  -20.362 1.00 43.68  ? 70  THR A OG1 1 
ATOM   533  C CG2 . THR A 1 66  ? -46.736 -3.397  -21.164 1.00 40.25  ? 70  THR A CG2 1 
ATOM   534  N N   . ALA A 1 67  ? -46.563 -6.887  -22.037 1.00 45.09  ? 71  ALA A N   1 
ATOM   535  C CA  . ALA A 1 67  ? -47.276 -7.694  -23.038 1.00 46.13  ? 71  ALA A CA  1 
ATOM   536  C C   . ALA A 1 67  ? -48.704 -7.179  -23.100 1.00 58.37  ? 71  ALA A C   1 
ATOM   537  O O   . ALA A 1 67  ? -49.139 -6.627  -22.110 1.00 59.84  ? 71  ALA A O   1 
ATOM   538  C CB  . ALA A 1 67  ? -47.189 -9.145  -22.659 1.00 50.78  ? 71  ALA A CB  1 
ATOM   539  N N   . SER A 1 68  ? -49.363 -7.286  -24.249 1.00 65.50  ? 72  SER A N   1 
ATOM   540  C CA  . SER A 1 68  ? -50.696 -6.689  -24.524 1.00 69.03  ? 72  SER A CA  1 
ATOM   541  C C   . SER A 1 68  ? -51.741 -7.450  -23.705 1.00 82.51  ? 72  SER A C   1 
ATOM   542  O O   . SER A 1 68  ? -51.495 -8.650  -23.455 1.00 77.00  ? 72  SER A O   1 
ATOM   543  C CB  . SER A 1 68  ? -50.992 -6.795  -25.974 1.00 67.87  ? 72  SER A CB  1 
ATOM   544  O OG  . SER A 1 68  ? -50.943 -8.160  -26.319 1.00 55.46  ? 72  SER A OG  1 
ATOM   545  N N   . SER A 1 69  ? -52.854 -6.800  -23.325 1.00 105.36 ? 73  SER A N   1 
ATOM   546  C CA  . SER A 1 69  ? -53.878 -7.349  -22.384 1.00 111.61 ? 73  SER A CA  1 
ATOM   547  C C   . SER A 1 69  ? -55.291 -7.353  -23.003 1.00 103.64 ? 73  SER A C   1 
ATOM   548  O O   . SER A 1 69  ? -55.793 -6.253  -23.361 1.00 94.39  ? 73  SER A O   1 
ATOM   549  C CB  . SER A 1 69  ? -53.812 -6.613  -21.056 1.00 114.72 ? 73  SER A CB  1 
ATOM   550  O OG  . SER A 1 69  ? -53.627 -5.216  -21.259 1.00 109.69 ? 73  SER A OG  1 
ATOM   551  N N   . THR A 1 77  ? -58.606 -14.140 -27.163 1.00 116.00 ? 81  THR A N   1 
ATOM   552  C CA  . THR A 1 77  ? -58.446 -14.806 -28.483 1.00 108.65 ? 81  THR A CA  1 
ATOM   553  C C   . THR A 1 77  ? -57.572 -13.937 -29.424 1.00 107.84 ? 81  THR A C   1 
ATOM   554  O O   . THR A 1 77  ? -57.109 -14.507 -30.437 1.00 126.87 ? 81  THR A O   1 
ATOM   555  C CB  . THR A 1 77  ? -59.833 -15.212 -29.014 1.00 104.61 ? 81  THR A CB  1 
ATOM   556  O OG1 . THR A 1 77  ? -60.705 -14.081 -28.932 1.00 98.91  ? 81  THR A OG1 1 
ATOM   557  C CG2 . THR A 1 77  ? -60.458 -16.363 -28.250 1.00 93.77  ? 81  THR A CG2 1 
ATOM   558  N N   . ARG A 1 78  ? -57.324 -12.644 -29.110 1.00 91.69  ? 82  ARG A N   1 
ATOM   559  C CA  . ARG A 1 78  ? -56.308 -11.745 -29.760 1.00 75.71  ? 82  ARG A CA  1 
ATOM   560  C C   . ARG A 1 78  ? -54.873 -12.186 -29.426 1.00 65.84  ? 82  ARG A C   1 
ATOM   561  O O   . ARG A 1 78  ? -54.676 -12.836 -28.376 1.00 71.86  ? 82  ARG A O   1 
ATOM   562  C CB  . ARG A 1 78  ? -56.501 -10.290 -29.329 1.00 72.47  ? 82  ARG A CB  1 
ATOM   563  C CG  . ARG A 1 78  ? -57.825 -9.720  -29.817 1.00 82.27  ? 82  ARG A CG  1 
ATOM   564  C CD  . ARG A 1 78  ? -58.004 -8.271  -29.450 1.00 85.76  ? 82  ARG A CD  1 
ATOM   565  N NE  . ARG A 1 78  ? -57.092 -7.427  -30.209 1.00 84.71  ? 82  ARG A NE  1 
ATOM   566  C CZ  . ARG A 1 78  ? -57.445 -6.411  -31.003 1.00 99.49  ? 82  ARG A CZ  1 
ATOM   567  N NH1 . ARG A 1 78  ? -58.718 -6.088  -31.180 1.00 103.93 ? 82  ARG A NH1 1 
ATOM   568  N NH2 . ARG A 1 78  ? -56.508 -5.711  -31.627 1.00 97.71  ? 82  ARG A NH2 1 
ATOM   569  N N   . ASP A 1 79  ? -53.898 -11.900 -30.299 1.00 55.35  ? 83  ASP A N   1 
ATOM   570  C CA  . ASP A 1 79  ? -52.504 -12.412 -30.137 1.00 53.86  ? 83  ASP A CA  1 
ATOM   571  C C   . ASP A 1 79  ? -51.906 -11.724 -28.904 1.00 49.98  ? 83  ASP A C   1 
ATOM   572  O O   . ASP A 1 79  ? -52.212 -10.576 -28.692 1.00 49.47  ? 83  ASP A O   1 
ATOM   573  C CB  . ASP A 1 79  ? -51.564 -12.124 -31.324 1.00 51.34  ? 83  ASP A CB  1 
ATOM   574  C CG  . ASP A 1 79  ? -51.960 -12.639 -32.713 1.00 50.07  ? 83  ASP A CG  1 
ATOM   575  O OD1 . ASP A 1 79  ? -53.021 -13.315 -32.830 1.00 49.17  ? 83  ASP A OD1 1 
ATOM   576  O OD2 . ASP A 1 79  ? -51.208 -12.306 -33.692 1.00 50.57  ? 83  ASP A OD2 1 
ATOM   577  N N   . VAL A 1 80  ? -51.006 -12.386 -28.184 1.00 44.47  ? 84  VAL A N   1 
ATOM   578  C CA  . VAL A 1 80  ? -50.147 -11.729 -27.171 1.00 50.83  ? 84  VAL A CA  1 
ATOM   579  C C   . VAL A 1 80  ? -48.951 -11.081 -27.865 1.00 46.36  ? 84  VAL A C   1 
ATOM   580  O O   . VAL A 1 80  ? -48.132 -11.790 -28.471 1.00 45.69  ? 84  VAL A O   1 
ATOM   581  C CB  . VAL A 1 80  ? -49.766 -12.737 -26.079 1.00 53.92  ? 84  VAL A CB  1 
ATOM   582  C CG1 . VAL A 1 80  ? -48.801 -12.122 -25.083 1.00 51.97  ? 84  VAL A CG1 1 
ATOM   583  C CG2 . VAL A 1 80  ? -51.050 -13.251 -25.414 1.00 54.34  ? 84  VAL A CG2 1 
ATOM   584  N N   . LYS A 1 81  ? -48.819 -9.764  -27.700 1.00 44.44  ? 85  LYS A N   1 
ATOM   585  C CA  . LYS A 1 81  ? -47.791 -8.937  -28.390 1.00 47.16  ? 85  LYS A CA  1 
ATOM   586  C C   . LYS A 1 81  ? -46.859 -8.290  -27.368 1.00 46.42  ? 85  LYS A C   1 
ATOM   587  O O   . LYS A 1 81  ? -47.299 -7.955  -26.257 1.00 51.54  ? 85  LYS A O   1 
ATOM   588  C CB  . LYS A 1 81  ? -48.494 -7.913  -29.289 1.00 55.28  ? 85  LYS A CB  1 
ATOM   589  C CG  . LYS A 1 81  ? -49.178 -8.532  -30.504 1.00 65.82  ? 85  LYS A CG  1 
ATOM   590  C CD  . LYS A 1 81  ? -49.481 -7.530  -31.589 1.00 80.96  ? 85  LYS A CD  1 
ATOM   591  C CE  . LYS A 1 81  ? -50.903 -7.032  -31.536 1.00 82.74  ? 85  LYS A CE  1 
ATOM   592  N NZ  . LYS A 1 81  ? -51.810 -8.132  -31.948 1.00 84.10  ? 85  LYS A NZ  1 
ATOM   593  N N   . ILE A 1 82  ? -45.604 -8.108  -27.734 1.00 40.60  ? 86  ILE A N   1 
ATOM   594  C CA  . ILE A 1 82  ? -44.590 -7.468  -26.856 1.00 46.72  ? 86  ILE A CA  1 
ATOM   595  C C   . ILE A 1 82  ? -44.651 -5.958  -27.093 1.00 48.60  ? 86  ILE A C   1 
ATOM   596  O O   . ILE A 1 82  ? -44.243 -5.542  -28.184 1.00 40.36  ? 86  ILE A O   1 
ATOM   597  C CB  . ILE A 1 82  ? -43.212 -8.065  -27.156 1.00 50.66  ? 86  ILE A CB  1 
ATOM   598  C CG1 . ILE A 1 82  ? -43.234 -9.597  -27.039 1.00 58.69  ? 86  ILE A CG1 1 
ATOM   599  C CG2 . ILE A 1 82  ? -42.134 -7.445  -26.295 1.00 48.43  ? 86  ILE A CG2 1 
ATOM   600  C CD1 . ILE A 1 82  ? -43.956 -10.084 -25.787 1.00 65.15  ? 86  ILE A CD1 1 
ATOM   601  N N   . LEU A 1 83  ? -45.182 -5.190  -26.143 1.00 41.49  ? 87  LEU A N   1 
ATOM   602  C CA  . LEU A 1 83  ? -45.220 -3.705  -26.214 1.00 43.06  ? 87  LEU A CA  1 
ATOM   603  C C   . LEU A 1 83  ? -43.863 -3.200  -25.794 1.00 39.39  ? 87  LEU A C   1 
ATOM   604  O O   . LEU A 1 83  ? -43.405 -2.191  -26.300 1.00 41.60  ? 87  LEU A O   1 
ATOM   605  C CB  . LEU A 1 83  ? -46.386 -3.158  -25.380 1.00 44.46  ? 87  LEU A CB  1 
ATOM   606  C CG  . LEU A 1 83  ? -47.763 -3.651  -25.844 1.00 53.23  ? 87  LEU A CG  1 
ATOM   607  C CD1 . LEU A 1 83  ? -48.912 -3.154  -24.951 1.00 50.87  ? 87  LEU A CD1 1 
ATOM   608  C CD2 . LEU A 1 83  ? -48.022 -3.210  -27.293 1.00 53.65  ? 87  LEU A CD2 1 
ATOM   609  N N   . LYS A 1 84  ? -43.186 -3.924  -24.916 1.00 47.26  ? 88  LYS A N   1 
ATOM   610  C CA  . LYS A 1 84  ? -41.825 -3.561  -24.449 1.00 41.23  ? 88  LYS A CA  1 
ATOM   611  C C   . LYS A 1 84  ? -41.144 -4.875  -24.060 1.00 42.71  ? 88  LYS A C   1 
ATOM   612  O O   . LYS A 1 84  ? -41.630 -5.549  -23.138 1.00 44.04  ? 88  LYS A O   1 
ATOM   613  C CB  . LYS A 1 84  ? -41.836 -2.599  -23.241 1.00 43.07  ? 88  LYS A CB  1 
ATOM   614  C CG  . LYS A 1 84  ? -40.467 -2.250  -22.685 1.00 42.17  ? 88  LYS A CG  1 
ATOM   615  C CD  . LYS A 1 84  ? -39.468 -1.863  -23.807 1.00 51.68  ? 88  LYS A CD  1 
ATOM   616  C CE  . LYS A 1 84  ? -38.229 -1.111  -23.349 1.00 54.34  ? 88  LYS A CE  1 
ATOM   617  N NZ  . LYS A 1 84  ? -37.256 -1.978  -22.634 1.00 55.98  ? 88  LYS A NZ  1 
ATOM   618  N N   . ASP A 1 85  ? -40.054 -5.196  -24.736 1.00 39.13  ? 89  ASP A N   1 
ATOM   619  C CA  . ASP A 1 85  ? -39.229 -6.389  -24.484 1.00 41.45  ? 89  ASP A CA  1 
ATOM   620  C C   . ASP A 1 85  ? -38.258 -6.085  -23.359 1.00 41.12  ? 89  ASP A C   1 
ATOM   621  O O   . ASP A 1 85  ? -38.065 -4.883  -22.981 1.00 39.97  ? 89  ASP A O   1 
ATOM   622  C CB  . ASP A 1 85  ? -38.533 -6.862  -25.767 1.00 39.46  ? 89  ASP A CB  1 
ATOM   623  C CG  . ASP A 1 85  ? -38.479 -8.404  -25.818 1.00 48.84  ? 89  ASP A CG  1 
ATOM   624  O OD1 . ASP A 1 85  ? -38.358 -9.031  -24.716 1.00 40.24  ? 89  ASP A OD1 1 
ATOM   625  O OD2 . ASP A 1 85  ? -38.568 -8.974  -26.948 1.00 41.54  ? 89  ASP A OD2 1 
ATOM   626  N N   . LEU A 1 86  ? -37.662 -7.144  -22.857 1.00 35.04  ? 90  LEU A N   1 
ATOM   627  C CA  . LEU A 1 86  ? -36.530 -7.118  -21.909 1.00 37.77  ? 90  LEU A CA  1 
ATOM   628  C C   . LEU A 1 86  ? -35.419 -6.209  -22.444 1.00 43.55  ? 90  LEU A C   1 
ATOM   629  O O   . LEU A 1 86  ? -35.177 -6.245  -23.637 1.00 39.29  ? 90  LEU A O   1 
ATOM   630  C CB  . LEU A 1 86  ? -35.997 -8.542  -21.751 1.00 36.29  ? 90  LEU A CB  1 
ATOM   631  C CG  . LEU A 1 86  ? -36.639 -9.403  -20.665 1.00 43.56  ? 90  LEU A CG  1 
ATOM   632  C CD1 . LEU A 1 86  ? -38.111 -9.245  -20.635 1.00 53.16  ? 90  LEU A CD1 1 
ATOM   633  C CD2 . LEU A 1 86  ? -36.301 -10.861 -20.882 1.00 43.76  ? 90  LEU A CD2 1 
ATOM   634  N N   . ASP A 1 87  ? -34.703 -5.527  -21.559 1.00 44.69  ? 91  ASP A N   1 
ATOM   635  C CA  . ASP A 1 87  ? -33.439 -4.837  -21.893 1.00 47.08  ? 91  ASP A CA  1 
ATOM   636  C C   . ASP A 1 87  ? -32.303 -5.846  -21.967 1.00 52.12  ? 91  ASP A C   1 
ATOM   637  O O   . ASP A 1 87  ? -31.340 -5.520  -22.591 1.00 51.75  ? 91  ASP A O   1 
ATOM   638  C CB  . ASP A 1 87  ? -33.056 -3.787  -20.848 1.00 54.24  ? 91  ASP A CB  1 
ATOM   639  C CG  . ASP A 1 87  ? -34.035 -2.633  -20.826 1.00 56.61  ? 91  ASP A CG  1 
ATOM   640  O OD1 . ASP A 1 87  ? -34.397 -2.213  -21.918 1.00 58.28  ? 91  ASP A OD1 1 
ATOM   641  O OD2 . ASP A 1 87  ? -34.529 -2.267  -19.722 1.00 64.54  ? 91  ASP A OD2 1 
ATOM   642  N N   . GLU A 1 88  ? -32.345 -6.968  -21.258 1.00 50.37  ? 92  GLU A N   1 
ATOM   643  C CA  . GLU A 1 88  ? -31.129 -7.836  -21.136 1.00 55.85  ? 92  GLU A CA  1 
ATOM   644  C C   . GLU A 1 88  ? -31.401 -9.225  -21.736 1.00 45.13  ? 92  GLU A C   1 
ATOM   645  O O   . GLU A 1 88  ? -32.582 -9.632  -21.854 1.00 46.27  ? 92  GLU A O   1 
ATOM   646  C CB  . GLU A 1 88  ? -30.598 -7.890  -19.700 1.00 61.77  ? 92  GLU A CB  1 
ATOM   647  C CG  . GLU A 1 88  ? -30.158 -6.519  -19.145 1.00 73.68  ? 92  GLU A CG  1 
ATOM   648  C CD  . GLU A 1 88  ? -29.045 -5.718  -19.852 1.00 76.97  ? 92  GLU A CD  1 
ATOM   649  O OE1 . GLU A 1 88  ? -28.210 -6.293  -20.607 1.00 68.66  ? 92  GLU A OE1 1 
ATOM   650  O OE2 . GLU A 1 88  ? -28.989 -4.490  -19.633 1.00 77.47  ? 92  GLU A OE2 1 
ATOM   651  N N   . ASP A 1 89  ? -30.316 -9.883  -22.141 1.00 49.86  ? 93  ASP A N   1 
ATOM   652  C CA  . ASP A 1 89  ? -30.276 -11.272 -22.670 1.00 51.23  ? 93  ASP A CA  1 
ATOM   653  C C   . ASP A 1 89  ? -30.602 -12.239 -21.528 1.00 46.40  ? 93  ASP A C   1 
ATOM   654  O O   . ASP A 1 89  ? -30.250 -11.927 -20.399 1.00 48.57  ? 93  ASP A O   1 
ATOM   655  C CB  . ASP A 1 89  ? -28.913 -11.564 -23.292 1.00 49.97  ? 93  ASP A CB  1 
ATOM   656  C CG  . ASP A 1 89  ? -28.625 -10.671 -24.499 1.00 58.86  ? 93  ASP A CG  1 
ATOM   657  O OD1 . ASP A 1 89  ? -29.534 -10.466 -25.302 1.00 54.74  ? 93  ASP A OD1 1 
ATOM   658  O OD2 . ASP A 1 89  ? -27.515 -10.137 -24.592 1.00 69.16  ? 93  ASP A OD2 1 
ATOM   659  N N   . ILE A 1 90  ? -31.243 -13.367 -21.822 1.00 44.46  ? 94  ILE A N   1 
ATOM   660  C CA  . ILE A 1 90  ? -31.538 -14.382 -20.768 1.00 48.58  ? 94  ILE A CA  1 
ATOM   661  C C   . ILE A 1 90  ? -30.895 -15.731 -21.142 1.00 46.74  ? 94  ILE A C   1 
ATOM   662  O O   . ILE A 1 90  ? -31.015 -16.644 -20.323 1.00 50.41  ? 94  ILE A O   1 
ATOM   663  C CB  . ILE A 1 90  ? -33.056 -14.479 -20.491 1.00 41.02  ? 94  ILE A CB  1 
ATOM   664  C CG1 . ILE A 1 90  ? -33.805 -14.954 -21.733 1.00 40.27  ? 94  ILE A CG1 1 
ATOM   665  C CG2 . ILE A 1 90  ? -33.602 -13.159 -19.924 1.00 42.01  ? 94  ILE A CG2 1 
ATOM   666  C CD1 . ILE A 1 90  ? -35.246 -15.260 -21.500 1.00 37.61  ? 94  ILE A CD1 1 
ATOM   667  N N   . ARG A 1 91  ? -30.205 -15.843 -22.285 1.00 46.51  ? 95  ARG A N   1 
ATOM   668  C CA  . ARG A 1 91  ? -29.599 -17.113 -22.773 1.00 52.00  ? 95  ARG A CA  1 
ATOM   669  C C   . ARG A 1 91  ? -28.714 -17.667 -21.655 1.00 46.01  ? 95  ARG A C   1 
ATOM   670  O O   . ARG A 1 91  ? -27.936 -16.897 -21.101 1.00 50.15  ? 95  ARG A O   1 
ATOM   671  C CB  . ARG A 1 91  ? -28.751 -16.926 -24.035 1.00 57.13  ? 95  ARG A CB  1 
ATOM   672  C CG  . ARG A 1 91  ? -28.109 -18.215 -24.553 1.00 65.35  ? 95  ARG A CG  1 
ATOM   673  C CD  . ARG A 1 91  ? -27.516 -18.126 -25.956 1.00 64.09  ? 95  ARG A CD  1 
ATOM   674  N NE  . ARG A 1 91  ? -28.304 -18.904 -26.901 1.00 79.32  ? 95  ARG A NE  1 
ATOM   675  C CZ  . ARG A 1 91  ? -29.515 -18.575 -27.377 1.00 88.21  ? 95  ARG A CZ  1 
ATOM   676  N NH1 . ARG A 1 91  ? -30.135 -17.450 -27.026 1.00 101.03 ? 95  ARG A NH1 1 
ATOM   677  N NH2 . ARG A 1 91  ? -30.112 -19.394 -28.226 1.00 80.40  ? 95  ARG A NH2 1 
ATOM   678  N N   . GLY A 1 92  ? -28.911 -18.922 -21.263 1.00 48.92  ? 96  GLY A N   1 
ATOM   679  C CA  . GLY A 1 92  ? -28.074 -19.579 -20.242 1.00 46.21  ? 96  GLY A CA  1 
ATOM   680  C C   . GLY A 1 92  ? -28.298 -19.014 -18.850 1.00 49.35  ? 96  GLY A C   1 
ATOM   681  O O   . GLY A 1 92  ? -27.475 -19.277 -17.977 1.00 45.58  ? 96  GLY A O   1 
ATOM   682  N N   . LYS A 1 93  ? -29.383 -18.276 -18.604 1.00 43.88  ? 97  LYS A N   1 
ATOM   683  C CA  . LYS A 1 93  ? -29.620 -17.747 -17.237 1.00 42.82  ? 97  LYS A CA  1 
ATOM   684  C C   . LYS A 1 93  ? -30.812 -18.443 -16.599 1.00 40.20  ? 97  LYS A C   1 
ATOM   685  O O   . LYS A 1 93  ? -31.710 -18.908 -17.323 1.00 44.28  ? 97  LYS A O   1 
ATOM   686  C CB  . LYS A 1 93  ? -29.831 -16.228 -17.263 1.00 52.37  ? 97  LYS A CB  1 
ATOM   687  C CG  . LYS A 1 93  ? -28.694 -15.447 -17.908 1.00 51.35  ? 97  LYS A CG  1 
ATOM   688  C CD  . LYS A 1 93  ? -28.832 -13.948 -17.724 1.00 58.76  ? 97  LYS A CD  1 
ATOM   689  C CE  . LYS A 1 93  ? -27.789 -13.166 -18.483 1.00 58.21  ? 97  LYS A CE  1 
ATOM   690  N NZ  . LYS A 1 93  ? -27.944 -11.733 -18.180 1.00 60.77  ? 97  LYS A NZ  1 
ATOM   691  N N   . ASP A 1 94  ? -30.841 -18.446 -15.264 1.00 42.65  ? 98  ASP A N   1 
ATOM   692  C CA  . ASP A 1 94  ? -32.051 -18.794 -14.478 1.00 39.69  ? 98  ASP A CA  1 
ATOM   693  C C   . ASP A 1 94  ? -33.042 -17.626 -14.527 1.00 45.04  ? 98  ASP A C   1 
ATOM   694  O O   . ASP A 1 94  ? -32.714 -16.558 -14.055 1.00 43.30  ? 98  ASP A O   1 
ATOM   695  C CB  . ASP A 1 94  ? -31.647 -19.114 -13.034 1.00 41.61  ? 98  ASP A CB  1 
ATOM   696  C CG  . ASP A 1 94  ? -30.943 -20.461 -12.939 1.00 47.97  ? 98  ASP A CG  1 
ATOM   697  O OD1 . ASP A 1 94  ? -31.394 -21.431 -13.630 1.00 43.80  ? 98  ASP A OD1 1 
ATOM   698  O OD2 . ASP A 1 94  ? -29.947 -20.519 -12.235 1.00 48.08  ? 98  ASP A OD2 1 
ATOM   699  N N   . VAL A 1 95  ? -34.250 -17.852 -15.013 1.00 40.64  ? 99  VAL A N   1 
ATOM   700  C CA  . VAL A 1 95  ? -35.225 -16.764 -15.199 1.00 41.28  ? 99  VAL A CA  1 
ATOM   701  C C   . VAL A 1 95  ? -36.438 -17.086 -14.358 1.00 41.63  ? 99  VAL A C   1 
ATOM   702  O O   . VAL A 1 95  ? -36.986 -18.172 -14.539 1.00 36.96  ? 99  VAL A O   1 
ATOM   703  C CB  . VAL A 1 95  ? -35.616 -16.640 -16.672 1.00 41.50  ? 99  VAL A CB  1 
ATOM   704  C CG1 . VAL A 1 95  ? -36.815 -15.714 -16.812 1.00 43.56  ? 99  VAL A CG1 1 
ATOM   705  C CG2 . VAL A 1 95  ? -34.446 -16.203 -17.515 1.00 43.37  ? 99  VAL A CG2 1 
ATOM   706  N N   . LEU A 1 96  ? -36.892 -16.122 -13.566 1.00 40.23  ? 100 LEU A N   1 
ATOM   707  C CA  . LEU A 1 96  ? -38.157 -16.186 -12.805 1.00 34.55  ? 100 LEU A CA  1 
ATOM   708  C C   . LEU A 1 96  ? -39.054 -15.064 -13.272 1.00 39.21  ? 100 LEU A C   1 
ATOM   709  O O   . LEU A 1 96  ? -38.698 -13.874 -13.038 1.00 38.36  ? 100 LEU A O   1 
ATOM   710  C CB  . LEU A 1 96  ? -37.834 -16.013 -11.315 1.00 36.16  ? 100 LEU A CB  1 
ATOM   711  C CG  . LEU A 1 96  ? -38.997 -16.251 -10.350 1.00 39.26  ? 100 LEU A CG  1 
ATOM   712  C CD1 . LEU A 1 96  ? -39.506 -17.684 -10.453 1.00 38.68  ? 100 LEU A CD1 1 
ATOM   713  C CD2 . LEU A 1 96  ? -38.607 -15.937 -8.906  1.00 40.74  ? 100 LEU A CD2 1 
ATOM   714  N N   . ILE A 1 97  ? -40.184 -15.426 -13.847 1.00 35.56  ? 101 ILE A N   1 
ATOM   715  C CA  . ILE A 1 97  ? -41.237 -14.473 -14.222 1.00 35.97  ? 101 ILE A CA  1 
ATOM   716  C C   . ILE A 1 97  ? -42.032 -14.144 -12.967 1.00 44.39  ? 101 ILE A C   1 
ATOM   717  O O   . ILE A 1 97  ? -42.439 -15.080 -12.275 1.00 39.50  ? 101 ILE A O   1 
ATOM   718  C CB  . ILE A 1 97  ? -42.094 -15.043 -15.357 1.00 36.13  ? 101 ILE A CB  1 
ATOM   719  C CG1 . ILE A 1 97  ? -41.259 -15.482 -16.564 1.00 37.18  ? 101 ILE A CG1 1 
ATOM   720  C CG2 . ILE A 1 97  ? -43.143 -14.034 -15.751 1.00 39.99  ? 101 ILE A CG2 1 
ATOM   721  C CD1 . ILE A 1 97  ? -42.089 -16.239 -17.560 1.00 38.25  ? 101 ILE A CD1 1 
ATOM   722  N N   . VAL A 1 98  ? -42.283 -12.855 -12.717 1.00 36.92  ? 102 VAL A N   1 
ATOM   723  C CA  . VAL A 1 98  ? -42.977 -12.343 -11.509 1.00 33.54  ? 102 VAL A CA  1 
ATOM   724  C C   . VAL A 1 98  ? -44.233 -11.613 -11.949 1.00 38.01  ? 102 VAL A C   1 
ATOM   725  O O   . VAL A 1 98  ? -44.106 -10.667 -12.731 1.00 39.05  ? 102 VAL A O   1 
ATOM   726  C CB  . VAL A 1 98  ? -42.014 -11.438 -10.734 1.00 35.65  ? 102 VAL A CB  1 
ATOM   727  C CG1 . VAL A 1 98  ? -42.635 -10.786 -9.506  1.00 36.35  ? 102 VAL A CG1 1 
ATOM   728  C CG2 . VAL A 1 98  ? -40.731 -12.170 -10.420 1.00 35.41  ? 102 VAL A CG2 1 
ATOM   729  N N   . GLU A 1 99  ? -45.400 -12.051 -11.475 1.00 36.36  ? 103 GLU A N   1 
ATOM   730  C CA  . GLU A 1 99  ? -46.703 -11.491 -11.853 1.00 41.14  ? 103 GLU A CA  1 
ATOM   731  C C   . GLU A 1 99  ? -47.501 -11.281 -10.574 1.00 37.67  ? 103 GLU A C   1 
ATOM   732  O O   . GLU A 1 99  ? -47.256 -11.991 -9.584  1.00 38.83  ? 103 GLU A O   1 
ATOM   733  C CB  . GLU A 1 99  ? -47.382 -12.399 -12.890 1.00 58.52  ? 103 GLU A CB  1 
ATOM   734  C CG  . GLU A 1 99  ? -48.660 -11.822 -13.480 1.00 67.70  ? 103 GLU A CG  1 
ATOM   735  C CD  . GLU A 1 99  ? -48.638 -10.487 -14.212 1.00 82.65  ? 103 GLU A CD  1 
ATOM   736  O OE1 . GLU A 1 99  ? -49.161 -10.455 -15.348 1.00 107.48 ? 103 GLU A OE1 1 
ATOM   737  O OE2 . GLU A 1 99  ? -48.195 -9.449  -13.631 1.00 92.32  ? 103 GLU A OE2 1 
ATOM   738  N N   . ASP A 1 100 ? -48.417 -10.323 -10.603 1.00 36.62  ? 104 ASP A N   1 
ATOM   739  C CA  . ASP A 1 100 ? -49.299 -10.011 -9.468  1.00 38.91  ? 104 ASP A CA  1 
ATOM   740  C C   . ASP A 1 100 ? -50.365 -11.121 -9.339  1.00 42.16  ? 104 ASP A C   1 
ATOM   741  O O   . ASP A 1 100 ? -50.645 -11.520 -8.212  1.00 42.61  ? 104 ASP A O   1 
ATOM   742  C CB  . ASP A 1 100 ? -49.921 -8.622  -9.568  1.00 40.24  ? 104 ASP A CB  1 
ATOM   743  C CG  . ASP A 1 100 ? -50.637 -8.231  -10.858 1.00 50.44  ? 104 ASP A CG  1 
ATOM   744  O OD1 . ASP A 1 100 ? -50.513 -8.942  -11.887 1.00 53.84  ? 104 ASP A OD1 1 
ATOM   745  O OD2 . ASP A 1 100 ? -51.350 -7.198  -10.809 1.00 65.32  ? 104 ASP A OD2 1 
ATOM   746  N N   . ILE A 1 101 ? -50.969 -11.568 -10.434 1.00 40.16  ? 105 ILE A N   1 
ATOM   747  C CA  . ILE A 1 101 ? -52.083 -12.558 -10.376 1.00 39.49  ? 105 ILE A CA  1 
ATOM   748  C C   . ILE A 1 101 ? -52.060 -13.387 -11.655 1.00 47.05  ? 105 ILE A C   1 
ATOM   749  O O   . ILE A 1 101 ? -51.741 -12.789 -12.711 1.00 42.31  ? 105 ILE A O   1 
ATOM   750  C CB  . ILE A 1 101 ? -53.433 -11.859 -10.154 1.00 42.69  ? 105 ILE A CB  1 
ATOM   751  C CG1 . ILE A 1 101 ? -54.574 -12.875 -10.071 1.00 41.66  ? 105 ILE A CG1 1 
ATOM   752  C CG2 . ILE A 1 101 ? -53.715 -10.795 -11.225 1.00 45.28  ? 105 ILE A CG2 1 
ATOM   753  C CD1 . ILE A 1 101 ? -55.799 -12.298 -9.411  1.00 48.19  ? 105 ILE A CD1 1 
ATOM   754  N N   . ILE A 1 102 ? -52.305 -14.706 -11.539 1.00 40.63  ? 106 ILE A N   1 
ATOM   755  C CA  . ILE A 1 102 ? -52.620 -15.640 -12.666 1.00 45.44  ? 106 ILE A CA  1 
ATOM   756  C C   . ILE A 1 102 ? -54.098 -15.959 -12.503 1.00 44.51  ? 106 ILE A C   1 
ATOM   757  O O   . ILE A 1 102 ? -54.505 -16.372 -11.364 1.00 41.67  ? 106 ILE A O   1 
ATOM   758  C CB  . ILE A 1 102 ? -51.729 -16.903 -12.652 1.00 49.69  ? 106 ILE A CB  1 
ATOM   759  C CG1 . ILE A 1 102 ? -50.266 -16.483 -12.526 1.00 70.08  ? 106 ILE A CG1 1 
ATOM   760  C CG2 . ILE A 1 102 ? -51.928 -17.828 -13.870 1.00 42.29  ? 106 ILE A CG2 1 
ATOM   761  C CD1 . ILE A 1 102 ? -49.283 -17.381 -13.259 1.00 81.34  ? 106 ILE A CD1 1 
ATOM   762  N N   . ASP A 1 103 ? -54.910 -15.697 -13.525 1.00 43.50  ? 107 ASP A N   1 
ATOM   763  C CA  . ASP A 1 103 ? -56.324 -16.166 -13.526 1.00 37.58  ? 107 ASP A CA  1 
ATOM   764  C C   . ASP A 1 103 ? -56.521 -17.094 -14.730 1.00 43.80  ? 107 ASP A C   1 
ATOM   765  O O   . ASP A 1 103 ? -56.217 -18.334 -14.611 1.00 42.76  ? 107 ASP A O   1 
ATOM   766  C CB  . ASP A 1 103 ? -57.324 -15.025 -13.378 1.00 42.20  ? 107 ASP A CB  1 
ATOM   767  C CG  . ASP A 1 103 ? -57.014 -13.728 -14.115 1.00 50.75  ? 107 ASP A CG  1 
ATOM   768  O OD1 . ASP A 1 103 ? -56.597 -13.786 -15.300 1.00 51.81  ? 107 ASP A OD1 1 
ATOM   769  O OD2 . ASP A 1 103 ? -57.237 -12.670 -13.495 1.00 58.26  ? 107 ASP A OD2 1 
ATOM   770  N N   . SER A 1 104 ? -56.768 -16.516 -15.910 1.00 47.05  ? 108 SER A N   1 
ATOM   771  C CA  . SER A 1 104 ? -56.961 -17.294 -17.161 1.00 47.48  ? 108 SER A CA  1 
ATOM   772  C C   . SER A 1 104 ? -55.690 -18.111 -17.435 1.00 45.88  ? 108 SER A C   1 
ATOM   773  O O   . SER A 1 104 ? -55.795 -19.249 -17.936 1.00 45.95  ? 108 SER A O   1 
ATOM   774  C CB  . SER A 1 104 ? -57.318 -16.370 -18.318 1.00 48.77  ? 108 SER A CB  1 
ATOM   775  O OG  . SER A 1 104 ? -56.125 -15.992 -18.983 1.00 48.22  ? 108 SER A OG  1 
ATOM   776  N N   . GLY A 1 105 ? -54.508 -17.529 -17.197 1.00 42.51  ? 109 GLY A N   1 
ATOM   777  C CA  . GLY A 1 105 ? -53.214 -18.125 -17.597 1.00 43.04  ? 109 GLY A CA  1 
ATOM   778  C C   . GLY A 1 105 ? -52.825 -17.861 -19.065 1.00 48.72  ? 109 GLY A C   1 
ATOM   779  O O   . GLY A 1 105 ? -51.718 -18.285 -19.451 1.00 43.40  ? 109 GLY A O   1 
ATOM   780  N N   . ASN A 1 106 ? -53.638 -17.129 -19.836 1.00 49.77  ? 110 ASN A N   1 
ATOM   781  C CA  . ASN A 1 106 ? -53.433 -16.911 -21.304 1.00 52.97  ? 110 ASN A CA  1 
ATOM   782  C C   . ASN A 1 106 ? -52.173 -16.080 -21.548 1.00 47.27  ? 110 ASN A C   1 
ATOM   783  O O   . ASN A 1 106 ? -51.316 -16.586 -22.268 1.00 51.76  ? 110 ASN A O   1 
ATOM   784  C CB  . ASN A 1 106 ? -54.656 -16.286 -21.983 1.00 52.82  ? 110 ASN A CB  1 
ATOM   785  C CG  . ASN A 1 106 ? -55.853 -17.226 -22.048 1.00 59.13  ? 110 ASN A CG  1 
ATOM   786  O OD1 . ASN A 1 106 ? -55.732 -18.440 -22.242 1.00 64.43  ? 110 ASN A OD1 1 
ATOM   787  N ND2 . ASN A 1 106 ? -57.042 -16.672 -21.886 1.00 66.73  ? 110 ASN A ND2 1 
ATOM   788  N N   . THR A 1 107 ? -51.990 -14.928 -20.873 1.00 44.90  ? 111 THR A N   1 
ATOM   789  C CA  . THR A 1 107 ? -50.779 -14.078 -21.046 1.00 46.41  ? 111 THR A CA  1 
ATOM   790  C C   . THR A 1 107 ? -49.517 -14.806 -20.592 1.00 43.49  ? 111 THR A C   1 
ATOM   791  O O   . THR A 1 107 ? -48.542 -14.880 -21.415 1.00 43.30  ? 111 THR A O   1 
ATOM   792  C CB  . THR A 1 107 ? -50.888 -12.741 -20.312 1.00 49.34  ? 111 THR A CB  1 
ATOM   793  O OG1 . THR A 1 107 ? -52.071 -12.150 -20.825 1.00 45.56  ? 111 THR A OG1 1 
ATOM   794  C CG2 . THR A 1 107 ? -49.718 -11.812 -20.537 1.00 49.77  ? 111 THR A CG2 1 
ATOM   795  N N   . LEU A 1 108 ? -49.487 -15.278 -19.339 1.00 38.75  ? 112 LEU A N   1 
ATOM   796  C CA  . LEU A 1 108 ? -48.275 -15.922 -18.776 1.00 44.85  ? 112 LEU A CA  1 
ATOM   797  C C   . LEU A 1 108 ? -47.857 -17.068 -19.693 1.00 41.80  ? 112 LEU A C   1 
ATOM   798  O O   . LEU A 1 108 ? -46.636 -17.305 -19.850 1.00 41.49  ? 112 LEU A O   1 
ATOM   799  C CB  . LEU A 1 108 ? -48.553 -16.449 -17.364 1.00 45.59  ? 112 LEU A CB  1 
ATOM   800  C CG  . LEU A 1 108 ? -47.951 -15.722 -16.167 1.00 57.85  ? 112 LEU A CG  1 
ATOM   801  C CD1 . LEU A 1 108 ? -46.568 -15.179 -16.432 1.00 60.27  ? 112 LEU A CD1 1 
ATOM   802  C CD2 . LEU A 1 108 ? -48.855 -14.622 -15.659 1.00 69.61  ? 112 LEU A CD2 1 
ATOM   803  N N   . SER A 1 109 ? -48.838 -17.831 -20.177 1.00 39.46  ? 113 SER A N   1 
ATOM   804  C CA  . SER A 1 109 ? -48.566 -18.993 -21.051 1.00 46.11  ? 113 SER A CA  1 
ATOM   805  C C   . SER A 1 109 ? -47.772 -18.547 -22.285 1.00 41.86  ? 113 SER A C   1 
ATOM   806  O O   . SER A 1 109 ? -46.698 -19.145 -22.610 1.00 39.55  ? 113 SER A O   1 
ATOM   807  C CB  . SER A 1 109 ? -49.851 -19.634 -21.467 1.00 45.52  ? 113 SER A CB  1 
ATOM   808  O OG  . SER A 1 109 ? -49.505 -20.856 -22.043 1.00 53.30  ? 113 SER A OG  1 
ATOM   809  N N   . LYS A 1 110 ? -48.254 -17.494 -22.939 1.00 44.45  ? 114 LYS A N   1 
ATOM   810  C CA  . LYS A 1 110 ? -47.669 -16.983 -24.223 1.00 45.34  ? 114 LYS A CA  1 
ATOM   811  C C   . LYS A 1 110 ? -46.356 -16.302 -23.897 1.00 41.89  ? 114 LYS A C   1 
ATOM   812  O O   . LYS A 1 110 ? -45.349 -16.562 -24.596 1.00 44.46  ? 114 LYS A O   1 
ATOM   813  C CB  . LYS A 1 110 ? -48.731 -16.129 -24.923 1.00 49.05  ? 114 LYS A CB  1 
ATOM   814  C CG  . LYS A 1 110 ? -49.903 -16.943 -25.446 1.00 51.89  ? 114 LYS A CG  1 
ATOM   815  C CD  . LYS A 1 110 ? -49.523 -17.481 -26.811 1.00 66.58  ? 114 LYS A CD  1 
ATOM   816  C CE  . LYS A 1 110 ? -49.950 -18.895 -27.117 1.00 72.44  ? 114 LYS A CE  1 
ATOM   817  N NZ  . LYS A 1 110 ? -49.082 -19.470 -28.179 1.00 71.30  ? 114 LYS A NZ  1 
ATOM   818  N N   . VAL A 1 111 ? -46.267 -15.629 -22.741 1.00 40.93  ? 115 VAL A N   1 
ATOM   819  C CA  . VAL A 1 111 ? -44.967 -14.992 -22.378 1.00 39.66  ? 115 VAL A CA  1 
ATOM   820  C C   . VAL A 1 111 ? -43.887 -16.049 -22.101 1.00 39.75  ? 115 VAL A C   1 
ATOM   821  O O   . VAL A 1 111 ? -42.712 -15.930 -22.568 1.00 38.64  ? 115 VAL A O   1 
ATOM   822  C CB  . VAL A 1 111 ? -45.136 -14.018 -21.201 1.00 40.99  ? 115 VAL A CB  1 
ATOM   823  C CG1 . VAL A 1 111 ? -43.776 -13.599 -20.684 1.00 42.80  ? 115 VAL A CG1 1 
ATOM   824  C CG2 . VAL A 1 111 ? -45.952 -12.791 -21.590 1.00 45.30  ? 115 VAL A CG2 1 
ATOM   825  N N   . ARG A 1 112 ? -44.232 -17.102 -21.368 1.00 42.39  ? 116 ARG A N   1 
ATOM   826  C CA  . ARG A 1 112 ? -43.262 -18.202 -21.117 1.00 42.03  ? 116 ARG A CA  1 
ATOM   827  C C   . ARG A 1 112 ? -42.753 -18.848 -22.426 1.00 35.85  ? 116 ARG A C   1 
ATOM   828  O O   . ARG A 1 112 ? -41.560 -19.097 -22.543 1.00 37.32  ? 116 ARG A O   1 
ATOM   829  C CB  . ARG A 1 112 ? -43.962 -19.220 -20.217 1.00 41.82  ? 116 ARG A CB  1 
ATOM   830  C CG  . ARG A 1 112 ? -43.002 -20.264 -19.696 1.00 45.02  ? 116 ARG A CG  1 
ATOM   831  C CD  . ARG A 1 112 ? -43.662 -21.330 -18.820 1.00 50.85  ? 116 ARG A CD  1 
ATOM   832  N NE  . ARG A 1 112 ? -42.591 -22.056 -18.168 1.00 48.34  ? 116 ARG A NE  1 
ATOM   833  C CZ  . ARG A 1 112 ? -41.706 -22.863 -18.777 1.00 61.39  ? 116 ARG A CZ  1 
ATOM   834  N NH1 . ARG A 1 112 ? -40.736 -23.422 -18.072 1.00 64.91  ? 116 ARG A NH1 1 
ATOM   835  N NH2 . ARG A 1 112 ? -41.768 -23.117 -20.074 1.00 56.56  ? 116 ARG A NH2 1 
ATOM   836  N N   . GLU A 1 113 ? -43.628 -19.122 -23.381 1.00 41.42  ? 117 GLU A N   1 
ATOM   837  C CA  . GLU A 1 113 ? -43.235 -19.660 -24.721 1.00 47.67  ? 117 GLU A CA  1 
ATOM   838  C C   . GLU A 1 113 ? -42.247 -18.715 -25.416 1.00 45.79  ? 117 GLU A C   1 
ATOM   839  O O   . GLU A 1 113 ? -41.282 -19.200 -25.986 1.00 40.19  ? 117 GLU A O   1 
ATOM   840  C CB  . GLU A 1 113 ? -44.452 -19.800 -25.632 1.00 49.20  ? 117 GLU A CB  1 
ATOM   841  C CG  . GLU A 1 113 ? -45.320 -20.956 -25.251 1.00 54.46  ? 117 GLU A CG  1 
ATOM   842  C CD  . GLU A 1 113 ? -46.420 -21.273 -26.243 1.00 57.12  ? 117 GLU A CD  1 
ATOM   843  O OE1 . GLU A 1 113 ? -46.592 -22.451 -26.549 1.00 72.98  ? 117 GLU A OE1 1 
ATOM   844  O OE2 . GLU A 1 113 ? -47.104 -20.348 -26.693 1.00 63.44  ? 117 GLU A OE2 1 
ATOM   845  N N   . ILE A 1 114 ? -42.470 -17.388 -25.367 1.00 43.43  ? 118 ILE A N   1 
ATOM   846  C CA  . ILE A 1 114 ? -41.592 -16.437 -26.105 1.00 35.79  ? 118 ILE A CA  1 
ATOM   847  C C   . ILE A 1 114 ? -40.203 -16.525 -25.506 1.00 36.64  ? 118 ILE A C   1 
ATOM   848  O O   . ILE A 1 114 ? -39.172 -16.591 -26.259 1.00 41.59  ? 118 ILE A O   1 
ATOM   849  C CB  . ILE A 1 114 ? -42.202 -15.004 -26.058 1.00 41.71  ? 118 ILE A CB  1 
ATOM   850  C CG1 . ILE A 1 114 ? -43.422 -14.930 -26.978 1.00 39.05  ? 118 ILE A CG1 1 
ATOM   851  C CG2 . ILE A 1 114 ? -41.140 -13.991 -26.421 1.00 39.22  ? 118 ILE A CG2 1 
ATOM   852  C CD1 . ILE A 1 114 ? -44.420 -13.837 -26.678 1.00 49.31  ? 118 ILE A CD1 1 
ATOM   853  N N   . LEU A 1 115 ? -40.140 -16.446 -24.174 1.00 38.44  ? 119 LEU A N   1 
ATOM   854  C CA  . LEU A 1 115 ? -38.849 -16.422 -23.452 1.00 34.88  ? 119 LEU A CA  1 
ATOM   855  C C   . LEU A 1 115 ? -38.143 -17.779 -23.614 1.00 38.01  ? 119 LEU A C   1 
ATOM   856  O O   . LEU A 1 115 ? -36.890 -17.809 -23.616 1.00 34.98  ? 119 LEU A O   1 
ATOM   857  C CB  . LEU A 1 115 ? -39.110 -16.098 -21.977 1.00 37.24  ? 119 LEU A CB  1 
ATOM   858  C CG  . LEU A 1 115 ? -39.672 -14.710 -21.664 1.00 41.41  ? 119 LEU A CG  1 
ATOM   859  C CD1 . LEU A 1 115 ? -39.530 -14.402 -20.177 1.00 43.11  ? 119 LEU A CD1 1 
ATOM   860  C CD2 . LEU A 1 115 ? -38.938 -13.642 -22.472 1.00 44.77  ? 119 LEU A CD2 1 
ATOM   861  N N   . SER A 1 116 ? -38.912 -18.869 -23.650 1.00 36.60  ? 120 SER A N   1 
ATOM   862  C CA  . SER A 1 116 ? -38.346 -20.237 -23.806 1.00 42.42  ? 120 SER A CA  1 
ATOM   863  C C   . SER A 1 116 ? -37.476 -20.293 -25.069 1.00 42.72  ? 120 SER A C   1 
ATOM   864  O O   . SER A 1 116 ? -36.358 -20.814 -25.002 1.00 45.23  ? 120 SER A O   1 
ATOM   865  C CB  . SER A 1 116 ? -39.464 -21.270 -23.786 1.00 44.90  ? 120 SER A CB  1 
ATOM   866  O OG  . SER A 1 116 ? -38.901 -22.557 -23.833 1.00 54.54  ? 120 SER A OG  1 
ATOM   867  N N   . LEU A 1 117 ? -37.903 -19.619 -26.147 1.00 49.01  ? 121 LEU A N   1 
ATOM   868  C CA  . LEU A 1 117 ? -37.163 -19.533 -27.437 1.00 45.96  ? 121 LEU A CA  1 
ATOM   869  C C   . LEU A 1 117 ? -35.743 -19.008 -27.226 1.00 42.21  ? 121 LEU A C   1 
ATOM   870  O O   . LEU A 1 117 ? -34.912 -19.262 -28.085 1.00 44.63  ? 121 LEU A O   1 
ATOM   871  C CB  . LEU A 1 117 ? -37.908 -18.632 -28.428 1.00 46.36  ? 121 LEU A CB  1 
ATOM   872  C CG  . LEU A 1 117 ? -39.272 -19.152 -28.832 1.00 48.05  ? 121 LEU A CG  1 
ATOM   873  C CD1 . LEU A 1 117 ? -39.967 -18.173 -29.767 1.00 48.58  ? 121 LEU A CD1 1 
ATOM   874  C CD2 . LEU A 1 117 ? -39.135 -20.539 -29.490 1.00 47.88  ? 121 LEU A CD2 1 
ATOM   875  N N   . ARG A 1 118 ? -35.444 -18.333 -26.124 1.00 38.93  ? 122 ARG A N   1 
ATOM   876  C CA  . ARG A 1 118 ? -34.132 -17.655 -25.938 1.00 44.51  ? 122 ARG A CA  1 
ATOM   877  C C   . ARG A 1 118 ? -33.196 -18.598 -25.205 1.00 41.92  ? 122 ARG A C   1 
ATOM   878  O O   . ARG A 1 118 ? -32.072 -18.191 -24.976 1.00 42.79  ? 122 ARG A O   1 
ATOM   879  C CB  . ARG A 1 118 ? -34.313 -16.298 -25.229 1.00 44.65  ? 122 ARG A CB  1 
ATOM   880  C CG  . ARG A 1 118 ? -35.332 -15.419 -25.951 1.00 44.53  ? 122 ARG A CG  1 
ATOM   881  C CD  . ARG A 1 118 ? -35.508 -14.013 -25.386 1.00 45.82  ? 122 ARG A CD  1 
ATOM   882  N NE  . ARG A 1 118 ? -36.613 -13.381 -26.067 1.00 40.91  ? 122 ARG A NE  1 
ATOM   883  C CZ  . ARG A 1 118 ? -37.103 -12.160 -25.805 1.00 48.19  ? 122 ARG A CZ  1 
ATOM   884  N NH1 . ARG A 1 118 ? -36.557 -11.349 -24.901 1.00 44.76  ? 122 ARG A NH1 1 
ATOM   885  N NH2 . ARG A 1 118 ? -38.174 -11.777 -26.465 1.00 45.68  ? 122 ARG A NH2 1 
ATOM   886  N N   . GLU A 1 119 ? -33.658 -19.801 -24.840 1.00 48.61  ? 123 GLU A N   1 
ATOM   887  C CA  . GLU A 1 119 ? -32.791 -20.858 -24.243 1.00 47.16  ? 123 GLU A CA  1 
ATOM   888  C C   . GLU A 1 119 ? -32.200 -20.344 -22.936 1.00 47.00  ? 123 GLU A C   1 
ATOM   889  O O   . GLU A 1 119 ? -30.985 -20.329 -22.713 1.00 45.05  ? 123 GLU A O   1 
ATOM   890  C CB  . GLU A 1 119 ? -31.775 -21.339 -25.274 1.00 47.82  ? 123 GLU A CB  1 
ATOM   891  C CG  . GLU A 1 119 ? -32.490 -21.960 -26.469 1.00 59.13  ? 123 GLU A CG  1 
ATOM   892  C CD  . GLU A 1 119 ? -31.624 -22.607 -27.548 1.00 71.66  ? 123 GLU A CD  1 
ATOM   893  O OE1 . GLU A 1 119 ? -30.954 -21.880 -28.336 1.00 76.43  ? 123 GLU A OE1 1 
ATOM   894  O OE2 . GLU A 1 119 ? -31.633 -23.836 -27.616 1.00 77.98  ? 123 GLU A OE2 1 
ATOM   895  N N   . PRO A 1 120 ? -33.071 -19.954 -21.981 1.00 40.02  ? 124 PRO A N   1 
ATOM   896  C CA  . PRO A 1 120 ? -32.596 -19.726 -20.624 1.00 47.20  ? 124 PRO A CA  1 
ATOM   897  C C   . PRO A 1 120 ? -32.211 -21.078 -19.991 1.00 46.46  ? 124 PRO A C   1 
ATOM   898  O O   . PRO A 1 120 ? -32.714 -22.066 -20.429 1.00 51.47  ? 124 PRO A O   1 
ATOM   899  C CB  . PRO A 1 120 ? -33.833 -19.099 -19.979 1.00 43.77  ? 124 PRO A CB  1 
ATOM   900  C CG  . PRO A 1 120 ? -34.986 -19.772 -20.674 1.00 44.50  ? 124 PRO A CG  1 
ATOM   901  C CD  . PRO A 1 120 ? -34.526 -19.857 -22.115 1.00 43.24  ? 124 PRO A CD  1 
ATOM   902  N N   . LYS A 1 121 ? -31.377 -21.079 -18.963 1.00 48.86  ? 125 LYS A N   1 
ATOM   903  C CA  . LYS A 1 121 ? -30.999 -22.310 -18.228 1.00 49.27  ? 125 LYS A CA  1 
ATOM   904  C C   . LYS A 1 121 ? -32.279 -22.899 -17.638 1.00 52.61  ? 125 LYS A C   1 
ATOM   905  O O   . LYS A 1 121 ? -32.536 -24.062 -17.878 1.00 55.96  ? 125 LYS A O   1 
ATOM   906  C CB  . LYS A 1 121 ? -29.941 -22.035 -17.159 1.00 52.71  ? 125 LYS A CB  1 
ATOM   907  C CG  . LYS A 1 121 ? -29.485 -23.273 -16.387 1.00 55.04  ? 125 LYS A CG  1 
ATOM   908  C CD  . LYS A 1 121 ? -28.227 -23.050 -15.585 1.00 61.31  ? 125 LYS A CD  1 
ATOM   909  C CE  . LYS A 1 121 ? -27.892 -24.178 -14.624 1.00 61.30  ? 125 LYS A CE  1 
ATOM   910  N NZ  . LYS A 1 121 ? -27.070 -23.684 -13.492 1.00 63.57  ? 125 LYS A NZ  1 
ATOM   911  N N   . SER A 1 122 ? -33.088 -22.090 -16.962 1.00 50.11  ? 126 SER A N   1 
ATOM   912  C CA  . SER A 1 122 ? -34.385 -22.504 -16.387 1.00 46.84  ? 126 SER A CA  1 
ATOM   913  C C   . SER A 1 122 ? -35.380 -21.355 -16.543 1.00 44.15  ? 126 SER A C   1 
ATOM   914  O O   . SER A 1 122 ? -34.940 -20.194 -16.629 1.00 41.79  ? 126 SER A O   1 
ATOM   915  C CB  . SER A 1 122 ? -34.193 -22.891 -14.932 1.00 47.46  ? 126 SER A CB  1 
ATOM   916  O OG  . SER A 1 122 ? -33.743 -21.783 -14.141 1.00 45.70  ? 126 SER A OG  1 
ATOM   917  N N   . LEU A 1 123 ? -36.662 -21.674 -16.485 1.00 36.78  ? 127 LEU A N   1 
ATOM   918  C CA  . LEU A 1 123 ? -37.778 -20.722 -16.598 1.00 40.47  ? 127 LEU A CA  1 
ATOM   919  C C   . LEU A 1 123 ? -38.804 -21.169 -15.582 1.00 45.16  ? 127 LEU A C   1 
ATOM   920  O O   . LEU A 1 123 ? -39.122 -22.336 -15.600 1.00 43.04  ? 127 LEU A O   1 
ATOM   921  C CB  . LEU A 1 123 ? -38.286 -20.794 -18.037 1.00 42.26  ? 127 LEU A CB  1 
ATOM   922  C CG  . LEU A 1 123 ? -39.132 -19.646 -18.563 1.00 45.41  ? 127 LEU A CG  1 
ATOM   923  C CD1 . LEU A 1 123 ? -38.546 -18.275 -18.197 1.00 41.67  ? 127 LEU A CD1 1 
ATOM   924  C CD2 . LEU A 1 123 ? -39.278 -19.781 -20.061 1.00 44.27  ? 127 LEU A CD2 1 
ATOM   925  N N   . ALA A 1 124 ? -39.242 -20.278 -14.710 1.00 44.14  ? 128 ALA A N   1 
ATOM   926  C CA  . ALA A 1 124 ? -40.233 -20.533 -13.637 1.00 43.94  ? 128 ALA A CA  1 
ATOM   927  C C   . ALA A 1 124 ? -41.083 -19.276 -13.464 1.00 42.17  ? 128 ALA A C   1 
ATOM   928  O O   . ALA A 1 124 ? -40.667 -18.187 -13.955 1.00 36.48  ? 128 ALA A O   1 
ATOM   929  C CB  . ALA A 1 124 ? -39.503 -20.919 -12.368 1.00 42.69  ? 128 ALA A CB  1 
ATOM   930  N N   . ILE A 1 125 ? -42.246 -19.420 -12.847 1.00 38.29  ? 129 ILE A N   1 
ATOM   931  C CA  . ILE A 1 125 ? -43.190 -18.315 -12.529 1.00 41.94  ? 129 ILE A CA  1 
ATOM   932  C C   . ILE A 1 125 ? -43.419 -18.226 -11.023 1.00 45.12  ? 129 ILE A C   1 
ATOM   933  O O   . ILE A 1 125 ? -43.591 -19.304 -10.358 1.00 36.31  ? 129 ILE A O   1 
ATOM   934  C CB  . ILE A 1 125 ? -44.511 -18.523 -13.283 1.00 41.16  ? 129 ILE A CB  1 
ATOM   935  C CG1 . ILE A 1 125 ? -44.259 -18.656 -14.787 1.00 46.08  ? 129 ILE A CG1 1 
ATOM   936  C CG2 . ILE A 1 125 ? -45.495 -17.426 -12.927 1.00 43.93  ? 129 ILE A CG2 1 
ATOM   937  C CD1 . ILE A 1 125 ? -45.494 -18.913 -15.600 1.00 45.28  ? 129 ILE A CD1 1 
ATOM   938  N N   . CYS A 1 126 ? -43.420 -16.992 -10.509 1.00 38.62  ? 130 CYS A N   1 
ATOM   939  C CA  . CYS A 1 126 ? -43.881 -16.611 -9.159  1.00 34.86  ? 130 CYS A CA  1 
ATOM   940  C C   . CYS A 1 126 ? -45.027 -15.608 -9.286  1.00 41.56  ? 130 CYS A C   1 
ATOM   941  O O   . CYS A 1 126 ? -44.850 -14.532 -9.870  1.00 40.28  ? 130 CYS A O   1 
ATOM   942  C CB  . CYS A 1 126 ? -42.737 -16.090 -8.295  1.00 36.57  ? 130 CYS A CB  1 
ATOM   943  S SG  . CYS A 1 126 ? -43.305 -15.583 -6.660  1.00 38.95  ? 130 CYS A SG  1 
ATOM   944  N N   . THR A 1 127 ? -46.193 -15.956 -8.770  1.00 34.41  ? 131 THR A N   1 
ATOM   945  C CA  . THR A 1 127 ? -47.369 -15.062 -8.720  1.00 36.94  ? 131 THR A CA  1 
ATOM   946  C C   . THR A 1 127 ? -47.663 -14.776 -7.248  1.00 41.59  ? 131 THR A C   1 
ATOM   947  O O   . THR A 1 127 ? -47.522 -15.704 -6.435  1.00 39.23  ? 131 THR A O   1 
ATOM   948  C CB  . THR A 1 127 ? -48.533 -15.676 -9.498  1.00 40.72  ? 131 THR A CB  1 
ATOM   949  O OG1 . THR A 1 127 ? -49.527 -14.664 -9.572  1.00 48.17  ? 131 THR A OG1 1 
ATOM   950  C CG2 . THR A 1 127 ? -49.105 -16.934 -8.863  1.00 38.24  ? 131 THR A CG2 1 
ATOM   951  N N   . LEU A 1 128 ? -48.114 -13.570 -6.922  1.00 43.93  ? 132 LEU A N   1 
ATOM   952  C CA  . LEU A 1 128 ? -48.626 -13.253 -5.573  1.00 40.23  ? 132 LEU A CA  1 
ATOM   953  C C   . LEU A 1 128 ? -49.977 -13.969 -5.399  1.00 40.42  ? 132 LEU A C   1 
ATOM   954  O O   . LEU A 1 128 ? -50.234 -14.530 -4.336  1.00 42.52  ? 132 LEU A O   1 
ATOM   955  C CB  . LEU A 1 128 ? -48.803 -11.738 -5.423  1.00 40.49  ? 132 LEU A CB  1 
ATOM   956  C CG  . LEU A 1 128 ? -49.253 -11.318 -4.031  1.00 43.01  ? 132 LEU A CG  1 
ATOM   957  C CD1 . LEU A 1 128 ? -48.240 -11.768 -2.973  1.00 41.64  ? 132 LEU A CD1 1 
ATOM   958  C CD2 . LEU A 1 128 ? -49.507 -9.839  -3.997  1.00 47.74  ? 132 LEU A CD2 1 
ATOM   959  N N   . LEU A 1 129 ? -50.868 -13.826 -6.371  1.00 34.19  ? 133 LEU A N   1 
ATOM   960  C CA  . LEU A 1 129 ? -52.251 -14.358 -6.270  1.00 36.02  ? 133 LEU A CA  1 
ATOM   961  C C   . LEU A 1 129 ? -52.486 -15.412 -7.353  1.00 37.15  ? 133 LEU A C   1 
ATOM   962  O O   . LEU A 1 129 ? -52.031 -15.232 -8.545  1.00 39.15  ? 133 LEU A O   1 
ATOM   963  C CB  . LEU A 1 129 ? -53.299 -13.264 -6.370  1.00 34.08  ? 133 LEU A CB  1 
ATOM   964  C CG  . LEU A 1 129 ? -53.266 -12.173 -5.313  1.00 37.74  ? 133 LEU A CG  1 
ATOM   965  C CD1 . LEU A 1 129 ? -54.382 -11.170 -5.581  1.00 39.43  ? 133 LEU A CD1 1 
ATOM   966  C CD2 . LEU A 1 129 ? -53.391 -12.741 -3.917  1.00 37.38  ? 133 LEU A CD2 1 
ATOM   967  N N   . ASP A 1 130 ? -53.223 -16.465 -6.988  1.00 37.52  ? 134 ASP A N   1 
ATOM   968  C CA  . ASP A 1 130 ? -53.660 -17.503 -7.962  1.00 34.66  ? 134 ASP A CA  1 
ATOM   969  C C   . ASP A 1 130 ? -55.170 -17.657 -7.825  1.00 41.29  ? 134 ASP A C   1 
ATOM   970  O O   . ASP A 1 130 ? -55.661 -17.806 -6.695  1.00 39.45  ? 134 ASP A O   1 
ATOM   971  C CB  . ASP A 1 130 ? -52.864 -18.790 -7.803  1.00 40.85  ? 134 ASP A CB  1 
ATOM   972  C CG  . ASP A 1 130 ? -53.318 -19.842 -8.823  1.00 53.41  ? 134 ASP A CG  1 
ATOM   973  O OD1 . ASP A 1 130 ? -54.005 -19.484 -9.801  1.00 53.21  ? 134 ASP A OD1 1 
ATOM   974  O OD2 . ASP A 1 130 ? -53.004 -20.996 -8.633  1.00 46.14  ? 134 ASP A OD2 1 
ATOM   975  N N   . LYS A 1 131 ? -55.876 -17.572 -8.948  1.00 40.63  ? 135 LYS A N   1 
ATOM   976  C CA  . LYS A 1 131 ? -57.300 -17.944 -9.077  1.00 44.09  ? 135 LYS A CA  1 
ATOM   977  C C   . LYS A 1 131 ? -57.354 -19.221 -9.902  1.00 45.10  ? 135 LYS A C   1 
ATOM   978  O O   . LYS A 1 131 ? -57.647 -19.143 -11.086 1.00 43.48  ? 135 LYS A O   1 
ATOM   979  C CB  . LYS A 1 131 ? -58.078 -16.833 -9.778  1.00 43.40  ? 135 LYS A CB  1 
ATOM   980  C CG  . LYS A 1 131 ? -58.443 -15.645 -8.916  1.00 40.13  ? 135 LYS A CG  1 
ATOM   981  C CD  . LYS A 1 131 ? -59.112 -14.572 -9.721  1.00 39.96  ? 135 LYS A CD  1 
ATOM   982  C CE  . LYS A 1 131 ? -59.465 -13.382 -8.876  1.00 41.67  ? 135 LYS A CE  1 
ATOM   983  N NZ  . LYS A 1 131 ? -60.398 -12.478 -9.589  1.00 46.24  ? 135 LYS A NZ  1 
ATOM   984  N N   . PRO A 1 132 ? -57.105 -20.418 -9.318  1.00 45.63  ? 136 PRO A N   1 
ATOM   985  C CA  . PRO A 1 132 ? -57.103 -21.661 -10.095 1.00 46.59  ? 136 PRO A CA  1 
ATOM   986  C C   . PRO A 1 132 ? -58.455 -21.927 -10.784 1.00 41.90  ? 136 PRO A C   1 
ATOM   987  O O   . PRO A 1 132 ? -58.441 -22.526 -11.780 1.00 45.19  ? 136 PRO A O   1 
ATOM   988  C CB  . PRO A 1 132 ? -56.820 -22.818 -9.108  1.00 46.98  ? 136 PRO A CB  1 
ATOM   989  C CG  . PRO A 1 132 ? -56.594 -22.153 -7.729  1.00 47.29  ? 136 PRO A CG  1 
ATOM   990  C CD  . PRO A 1 132 ? -56.902 -20.664 -7.875  1.00 45.20  ? 136 PRO A CD  1 
ATOM   991  N N   . SER A 1 133 ? -59.568 -21.434 -10.271 1.00 42.14  ? 137 SER A N   1 
ATOM   992  C CA  . SER A 1 133 ? -60.889 -21.664 -10.891 1.00 47.26  ? 137 SER A CA  1 
ATOM   993  C C   . SER A 1 133 ? -60.979 -20.929 -12.234 1.00 52.73  ? 137 SER A C   1 
ATOM   994  O O   . SER A 1 133 ? -61.886 -21.237 -12.944 1.00 49.21  ? 137 SER A O   1 
ATOM   995  C CB  . SER A 1 133 ? -62.010 -21.277 -9.988  1.00 49.70  ? 137 SER A CB  1 
ATOM   996  O OG  . SER A 1 133 ? -62.119 -19.864 -9.817  1.00 51.68  ? 137 SER A OG  1 
ATOM   997  N N   . ARG A 1 134 ? -60.127 -19.946 -12.536 1.00 50.39  ? 138 ARG A N   1 
ATOM   998  C CA  . ARG A 1 134 ? -60.257 -19.120 -13.772 1.00 46.93  ? 138 ARG A CA  1 
ATOM   999  C C   . ARG A 1 134 ? -59.395 -19.705 -14.905 1.00 40.90  ? 138 ARG A C   1 
ATOM   1000 O O   . ARG A 1 134 ? -59.405 -19.138 -16.013 1.00 49.09  ? 138 ARG A O   1 
ATOM   1001 C CB  . ARG A 1 134 ? -59.914 -17.667 -13.431 1.00 50.69  ? 138 ARG A CB  1 
ATOM   1002 C CG  . ARG A 1 134 ? -61.023 -16.920 -12.706 1.00 48.78  ? 138 ARG A CG  1 
ATOM   1003 C CD  . ARG A 1 134 ? -62.077 -16.369 -13.664 1.00 54.31  ? 138 ARG A CD  1 
ATOM   1004 N NE  . ARG A 1 134 ? -61.401 -15.530 -14.652 1.00 55.97  ? 138 ARG A NE  1 
ATOM   1005 C CZ  . ARG A 1 134 ? -61.092 -14.244 -14.494 1.00 56.47  ? 138 ARG A CZ  1 
ATOM   1006 N NH1 . ARG A 1 134 ? -61.462 -13.587 -13.408 1.00 56.37  ? 138 ARG A NH1 1 
ATOM   1007 N NH2 . ARG A 1 134 ? -60.437 -13.606 -15.445 1.00 64.99  ? 138 ARG A NH2 1 
ATOM   1008 N N   . ARG A 1 135 ? -58.670 -20.798 -14.668 1.00 43.07  ? 139 ARG A N   1 
ATOM   1009 C CA  . ARG A 1 135 ? -57.607 -21.281 -15.586 1.00 54.92  ? 139 ARG A CA  1 
ATOM   1010 C C   . ARG A 1 135 ? -58.274 -21.705 -16.904 1.00 61.77  ? 139 ARG A C   1 
ATOM   1011 O O   . ARG A 1 135 ? -59.285 -22.431 -16.859 1.00 55.54  ? 139 ARG A O   1 
ATOM   1012 C CB  . ARG A 1 135 ? -56.791 -22.401 -14.934 1.00 52.78  ? 139 ARG A CB  1 
ATOM   1013 C CG  . ARG A 1 135 ? -55.476 -22.741 -15.629 1.00 62.25  ? 139 ARG A CG  1 
ATOM   1014 C CD  . ARG A 1 135 ? -54.245 -21.842 -15.390 1.00 60.22  ? 139 ARG A CD  1 
ATOM   1015 N NE  . ARG A 1 135 ? -54.595 -20.871 -14.416 1.00 60.22  ? 139 ARG A NE  1 
ATOM   1016 C CZ  . ARG A 1 135 ? -54.092 -20.751 -13.197 1.00 54.51  ? 139 ARG A CZ  1 
ATOM   1017 N NH1 . ARG A 1 135 ? -53.068 -21.457 -12.766 1.00 57.94  ? 139 ARG A NH1 1 
ATOM   1018 N NH2 . ARG A 1 135 ? -54.640 -19.864 -12.406 1.00 45.18  ? 139 ARG A NH2 1 
ATOM   1019 N N   . GLU A 1 136 ? -57.773 -21.193 -18.027 1.00 53.90  ? 140 GLU A N   1 
ATOM   1020 C CA  . GLU A 1 136 ? -58.233 -21.548 -19.404 1.00 58.38  ? 140 GLU A CA  1 
ATOM   1021 C C   . GLU A 1 136 ? -57.133 -22.352 -20.104 1.00 62.07  ? 140 GLU A C   1 
ATOM   1022 O O   . GLU A 1 136 ? -57.442 -23.183 -20.949 1.00 61.65  ? 140 GLU A O   1 
ATOM   1023 C CB  . GLU A 1 136 ? -58.596 -20.280 -20.179 1.00 54.61  ? 140 GLU A CB  1 
ATOM   1024 C CG  . GLU A 1 136 ? -59.884 -19.649 -19.705 1.00 57.17  ? 140 GLU A CG  1 
ATOM   1025 C CD  . GLU A 1 136 ? -60.237 -18.348 -20.399 1.00 63.56  ? 140 GLU A CD  1 
ATOM   1026 O OE1 . GLU A 1 136 ? -59.582 -18.009 -21.370 1.00 71.63  ? 140 GLU A OE1 1 
ATOM   1027 O OE2 . GLU A 1 136 ? -61.171 -17.683 -19.970 1.00 70.89  ? 140 GLU A OE2 1 
ATOM   1028 N N   . VAL A 1 137 ? -55.878 -22.117 -19.748 1.00 59.83  ? 141 VAL A N   1 
ATOM   1029 C CA  . VAL A 1 137 ? -54.715 -22.747 -20.406 1.00 57.41  ? 141 VAL A CA  1 
ATOM   1030 C C   . VAL A 1 137 ? -53.844 -23.223 -19.271 1.00 64.51  ? 141 VAL A C   1 
ATOM   1031 O O   . VAL A 1 137 ? -53.603 -22.420 -18.358 1.00 72.44  ? 141 VAL A O   1 
ATOM   1032 C CB  . VAL A 1 137 ? -53.951 -21.736 -21.279 1.00 67.37  ? 141 VAL A CB  1 
ATOM   1033 C CG1 . VAL A 1 137 ? -52.700 -22.358 -21.876 1.00 69.17  ? 141 VAL A CG1 1 
ATOM   1034 C CG2 . VAL A 1 137 ? -54.821 -21.124 -22.369 1.00 71.54  ? 141 VAL A CG2 1 
ATOM   1035 N N   . ASN A 1 138 ? -53.340 -24.439 -19.339 1.00 62.53  ? 142 ASN A N   1 
ATOM   1036 C CA  . ASN A 1 138 ? -52.496 -24.917 -18.232 1.00 66.40  ? 142 ASN A CA  1 
ATOM   1037 C C   . ASN A 1 138 ? -51.127 -24.272 -18.401 1.00 69.45  ? 142 ASN A C   1 
ATOM   1038 O O   . ASN A 1 138 ? -50.649 -24.209 -19.538 1.00 74.69  ? 142 ASN A O   1 
ATOM   1039 C CB  . ASN A 1 138 ? -52.475 -26.435 -18.129 1.00 78.87  ? 142 ASN A CB  1 
ATOM   1040 C CG  . ASN A 1 138 ? -52.792 -26.808 -16.703 1.00 90.91  ? 142 ASN A CG  1 
ATOM   1041 O OD1 . ASN A 1 138 ? -51.916 -27.291 -15.987 1.00 85.99  ? 142 ASN A OD1 1 
ATOM   1042 N ND2 . ASN A 1 138 ? -54.001 -26.466 -16.263 1.00 80.66  ? 142 ASN A ND2 1 
ATOM   1043 N N   . VAL A 1 139 ? -50.568 -23.733 -17.320 1.00 55.11  ? 143 VAL A N   1 
ATOM   1044 C CA  . VAL A 1 139 ? -49.148 -23.296 -17.282 1.00 51.47  ? 143 VAL A CA  1 
ATOM   1045 C C   . VAL A 1 139 ? -48.604 -23.629 -15.890 1.00 50.71  ? 143 VAL A C   1 
ATOM   1046 O O   . VAL A 1 139 ? -49.291 -23.491 -14.876 1.00 48.97  ? 143 VAL A O   1 
ATOM   1047 C CB  . VAL A 1 139 ? -49.037 -21.809 -17.706 1.00 55.91  ? 143 VAL A CB  1 
ATOM   1048 C CG1 . VAL A 1 139 ? -49.881 -20.897 -16.838 1.00 52.05  ? 143 VAL A CG1 1 
ATOM   1049 C CG2 . VAL A 1 139 ? -47.594 -21.325 -17.757 1.00 58.87  ? 143 VAL A CG2 1 
ATOM   1050 N N   . PRO A 1 140 ? -47.356 -24.134 -15.805 1.00 52.39  ? 144 PRO A N   1 
ATOM   1051 C CA  . PRO A 1 140 ? -46.750 -24.453 -14.516 1.00 51.56  ? 144 PRO A CA  1 
ATOM   1052 C C   . PRO A 1 140 ? -46.413 -23.137 -13.786 1.00 53.31  ? 144 PRO A C   1 
ATOM   1053 O O   . PRO A 1 140 ? -45.898 -22.206 -14.424 1.00 52.00  ? 144 PRO A O   1 
ATOM   1054 C CB  . PRO A 1 140 ? -45.505 -25.285 -14.861 1.00 53.56  ? 144 PRO A CB  1 
ATOM   1055 C CG  . PRO A 1 140 ? -45.177 -24.932 -16.315 1.00 55.81  ? 144 PRO A CG  1 
ATOM   1056 C CD  . PRO A 1 140 ? -46.460 -24.417 -16.939 1.00 54.77  ? 144 PRO A CD  1 
ATOM   1057 N N   . VAL A 1 141 ? -46.763 -23.078 -12.497 1.00 47.73  ? 145 VAL A N   1 
ATOM   1058 C CA  . VAL A 1 141 ? -46.494 -21.943 -11.565 1.00 45.10  ? 145 VAL A CA  1 
ATOM   1059 C C   . VAL A 1 141 ? -45.791 -22.501 -10.333 1.00 48.59  ? 145 VAL A C   1 
ATOM   1060 O O   . VAL A 1 141 ? -46.464 -23.009 -9.472  1.00 49.78  ? 145 VAL A O   1 
ATOM   1061 C CB  . VAL A 1 141 ? -47.781 -21.188 -11.228 1.00 43.84  ? 145 VAL A CB  1 
ATOM   1062 C CG1 . VAL A 1 141 ? -47.525 -19.978 -10.334 1.00 46.44  ? 145 VAL A CG1 1 
ATOM   1063 C CG2 . VAL A 1 141 ? -48.504 -20.760 -12.498 1.00 48.47  ? 145 VAL A CG2 1 
ATOM   1064 N N   . GLU A 1 142 ? -44.479 -22.333 -10.251 1.00 39.92  ? 146 GLU A N   1 
ATOM   1065 C CA  . GLU A 1 142 ? -43.650 -22.919 -9.175  1.00 43.21  ? 146 GLU A CA  1 
ATOM   1066 C C   . GLU A 1 142 ? -43.877 -22.222 -7.808  1.00 49.87  ? 146 GLU A C   1 
ATOM   1067 O O   . GLU A 1 142 ? -43.793 -22.892 -6.795  1.00 44.90  ? 146 GLU A O   1 
ATOM   1068 C CB  . GLU A 1 142 ? -42.201 -22.926 -9.642  1.00 46.39  ? 146 GLU A CB  1 
ATOM   1069 C CG  . GLU A 1 142 ? -41.958 -23.771 -10.904 1.00 58.67  ? 146 GLU A CG  1 
ATOM   1070 C CD  . GLU A 1 142 ? -42.378 -23.283 -12.306 1.00 62.91  ? 146 GLU A CD  1 
ATOM   1071 O OE1 . GLU A 1 142 ? -42.074 -24.034 -13.242 1.00 58.50  ? 146 GLU A OE1 1 
ATOM   1072 O OE2 . GLU A 1 142 ? -42.999 -22.160 -12.493 1.00 47.23  ? 146 GLU A OE2 1 
ATOM   1073 N N   . PHE A 1 143 ? -44.206 -20.934 -7.724  1.00 44.70  ? 147 PHE A N   1 
ATOM   1074 C CA  . PHE A 1 143 ? -44.277 -20.199 -6.432  1.00 38.75  ? 147 PHE A CA  1 
ATOM   1075 C C   . PHE A 1 143 ? -45.499 -19.302 -6.422  1.00 43.50  ? 147 PHE A C   1 
ATOM   1076 O O   . PHE A 1 143 ? -45.749 -18.497 -7.399  1.00 41.89  ? 147 PHE A O   1 
ATOM   1077 C CB  . PHE A 1 143 ? -43.042 -19.325 -6.267  1.00 45.04  ? 147 PHE A CB  1 
ATOM   1078 C CG  . PHE A 1 143 ? -41.738 -20.052 -6.391  1.00 42.43  ? 147 PHE A CG  1 
ATOM   1079 C CD1 . PHE A 1 143 ? -41.156 -20.645 -5.285  1.00 46.13  ? 147 PHE A CD1 1 
ATOM   1080 C CD2 . PHE A 1 143 ? -41.081 -20.115 -7.603  1.00 39.88  ? 147 PHE A CD2 1 
ATOM   1081 C CE1 . PHE A 1 143 ? -39.927 -21.252 -5.397  1.00 39.91  ? 147 PHE A CE1 1 
ATOM   1082 C CE2 . PHE A 1 143 ? -39.838 -20.712 -7.719  1.00 38.96  ? 147 PHE A CE2 1 
ATOM   1083 C CZ  . PHE A 1 143 ? -39.275 -21.309 -6.617  1.00 45.03  ? 147 PHE A CZ  1 
ATOM   1084 N N   . ILE A 1 144 ? -46.320 -19.489 -5.407  1.00 35.08  ? 148 ILE A N   1 
ATOM   1085 C CA  . ILE A 1 144 ? -47.661 -18.857 -5.305  1.00 36.13  ? 148 ILE A CA  1 
ATOM   1086 C C   . ILE A 1 144 ? -47.791 -18.255 -3.905  1.00 39.76  ? 148 ILE A C   1 
ATOM   1087 O O   . ILE A 1 144 ? -47.565 -19.010 -2.914  1.00 39.35  ? 148 ILE A O   1 
ATOM   1088 C CB  . ILE A 1 144 ? -48.784 -19.878 -5.601  1.00 38.07  ? 148 ILE A CB  1 
ATOM   1089 C CG1 . ILE A 1 144 ? -48.708 -20.460 -7.017  1.00 41.90  ? 148 ILE A CG1 1 
ATOM   1090 C CG2 . ILE A 1 144 ? -50.153 -19.253 -5.342  1.00 37.41  ? 148 ILE A CG2 1 
ATOM   1091 C CD1 . ILE A 1 144 ? -49.691 -21.644 -7.243  1.00 45.77  ? 148 ILE A CD1 1 
ATOM   1092 N N   . GLY A 1 145 ? -48.238 -17.009 -3.806  1.00 37.49  ? 149 GLY A N   1 
ATOM   1093 C CA  . GLY A 1 145 ? -48.385 -16.321 -2.517  1.00 38.44  ? 149 GLY A CA  1 
ATOM   1094 C C   . GLY A 1 145 ? -49.641 -16.799 -1.822  1.00 38.66  ? 149 GLY A C   1 
ATOM   1095 O O   . GLY A 1 145 ? -49.563 -17.337 -0.703  1.00 39.43  ? 149 GLY A O   1 
ATOM   1096 N N   . PHE A 1 146 ? -50.758 -16.645 -2.505  1.00 37.32  ? 150 PHE A N   1 
ATOM   1097 C CA  . PHE A 1 146 ? -52.109 -16.916 -1.970  1.00 37.18  ? 150 PHE A CA  1 
ATOM   1098 C C   . PHE A 1 146 ? -52.971 -17.539 -3.077  1.00 43.65  ? 150 PHE A C   1 
ATOM   1099 O O   . PHE A 1 146 ? -52.929 -16.972 -4.210  1.00 40.81  ? 150 PHE A O   1 
ATOM   1100 C CB  . PHE A 1 146 ? -52.761 -15.634 -1.472  1.00 35.00  ? 150 PHE A CB  1 
ATOM   1101 C CG  . PHE A 1 146 ? -51.995 -14.877 -0.410  1.00 41.53  ? 150 PHE A CG  1 
ATOM   1102 C CD1 . PHE A 1 146 ? -51.035 -13.931 -0.765  1.00 34.87  ? 150 PHE A CD1 1 
ATOM   1103 C CD2 . PHE A 1 146 ? -52.251 -15.114 0.943   1.00 40.06  ? 150 PHE A CD2 1 
ATOM   1104 C CE1 . PHE A 1 146 ? -50.354 -13.237 0.220   1.00 39.82  ? 150 PHE A CE1 1 
ATOM   1105 C CE2 . PHE A 1 146 ? -51.542 -14.443 1.925   1.00 39.14  ? 150 PHE A CE2 1 
ATOM   1106 C CZ  . PHE A 1 146 ? -50.599 -13.491 1.560   1.00 40.02  ? 150 PHE A CZ  1 
ATOM   1107 N N   . SER A 1 147 ? -53.739 -18.606 -2.766  1.00 35.59  ? 151 SER A N   1 
ATOM   1108 C CA  . SER A 1 147 ? -54.828 -19.143 -3.630  1.00 35.45  ? 151 SER A CA  1 
ATOM   1109 C C   . SER A 1 147 ? -56.128 -18.583 -3.173  1.00 33.74  ? 151 SER A C   1 
ATOM   1110 O O   . SER A 1 147 ? -56.420 -18.652 -2.000  1.00 37.00  ? 151 SER A O   1 
ATOM   1111 C CB  . SER A 1 147 ? -54.985 -20.660 -3.662  1.00 39.80  ? 151 SER A CB  1 
ATOM   1112 O OG  . SER A 1 147 ? -53.782 -21.206 -4.053  1.00 46.46  ? 151 SER A OG  1 
ATOM   1113 N N   . ILE A 1 148 ? -56.892 -18.040 -4.099  1.00 35.96  ? 152 ILE A N   1 
ATOM   1114 C CA  . ILE A 1 148 ? -58.116 -17.316 -3.715  1.00 37.60  ? 152 ILE A CA  1 
ATOM   1115 C C   . ILE A 1 148 ? -59.204 -17.765 -4.651  1.00 39.27  ? 152 ILE A C   1 
ATOM   1116 O O   . ILE A 1 148 ? -58.909 -18.221 -5.760  1.00 40.71  ? 152 ILE A O   1 
ATOM   1117 C CB  . ILE A 1 148 ? -57.919 -15.793 -3.806  1.00 40.93  ? 152 ILE A CB  1 
ATOM   1118 C CG1 . ILE A 1 148 ? -57.465 -15.359 -5.199  1.00 41.20  ? 152 ILE A CG1 1 
ATOM   1119 C CG2 . ILE A 1 148 ? -56.945 -15.316 -2.733  1.00 41.13  ? 152 ILE A CG2 1 
ATOM   1120 C CD1 . ILE A 1 148 ? -57.728 -13.879 -5.424  1.00 42.48  ? 152 ILE A CD1 1 
ATOM   1121 N N   . PRO A 1 149 ? -60.458 -17.608 -4.213  1.00 38.24  ? 153 PRO A N   1 
ATOM   1122 C CA  . PRO A 1 149 ? -61.591 -17.795 -5.093  1.00 42.21  ? 153 PRO A CA  1 
ATOM   1123 C C   . PRO A 1 149 ? -61.532 -16.651 -6.107  1.00 47.27  ? 153 PRO A C   1 
ATOM   1124 O O   . PRO A 1 149 ? -60.646 -15.785 -5.986  1.00 44.09  ? 153 PRO A O   1 
ATOM   1125 C CB  . PRO A 1 149 ? -62.840 -17.647 -4.214  1.00 46.59  ? 153 PRO A CB  1 
ATOM   1126 C CG  . PRO A 1 149 ? -62.326 -17.458 -2.779  1.00 47.14  ? 153 PRO A CG  1 
ATOM   1127 C CD  . PRO A 1 149 ? -60.845 -17.141 -2.872  1.00 44.09  ? 153 PRO A CD  1 
ATOM   1128 N N   . ASP A 1 150 ? -62.519 -16.611 -6.996  1.00 43.91  ? 154 ASP A N   1 
ATOM   1129 C CA  . ASP A 1 150 ? -62.669 -15.567 -8.052  1.00 51.10  ? 154 ASP A CA  1 
ATOM   1130 C C   . ASP A 1 150 ? -63.303 -14.295 -7.453  1.00 48.03  ? 154 ASP A C   1 
ATOM   1131 O O   . ASP A 1 150 ? -64.321 -13.848 -7.938  1.00 59.16  ? 154 ASP A O   1 
ATOM   1132 C CB  . ASP A 1 150 ? -63.450 -16.112 -9.252  1.00 45.92  ? 154 ASP A CB  1 
ATOM   1133 C CG  . ASP A 1 150 ? -63.415 -15.155 -10.443 1.00 50.18  ? 154 ASP A CG  1 
ATOM   1134 O OD1 . ASP A 1 150 ? -62.365 -14.472 -10.654 1.00 47.69  ? 154 ASP A OD1 1 
ATOM   1135 O OD2 . ASP A 1 150 ? -64.416 -15.083 -11.132 1.00 49.82  ? 154 ASP A OD2 1 
ATOM   1136 N N   . GLU A 1 151 ? -62.676 -13.711 -6.436  1.00 51.96  ? 155 GLU A N   1 
ATOM   1137 C CA  . GLU A 1 151 ? -63.104 -12.448 -5.788  1.00 49.63  ? 155 GLU A CA  1 
ATOM   1138 C C   . GLU A 1 151 ? -62.684 -11.245 -6.657  1.00 45.62  ? 155 GLU A C   1 
ATOM   1139 O O   . GLU A 1 151 ? -61.630 -11.326 -7.365  1.00 40.76  ? 155 GLU A O   1 
ATOM   1140 C CB  . GLU A 1 151 ? -62.454 -12.397 -4.402  1.00 53.75  ? 155 GLU A CB  1 
ATOM   1141 C CG  . GLU A 1 151 ? -62.875 -13.528 -3.497  1.00 60.51  ? 155 GLU A CG  1 
ATOM   1142 C CD  . GLU A 1 151 ? -64.274 -13.369 -2.921  1.00 70.98  ? 155 GLU A CD  1 
ATOM   1143 O OE1 . GLU A 1 151 ? -64.789 -14.357 -2.341  1.00 70.79  ? 155 GLU A OE1 1 
ATOM   1144 O OE2 . GLU A 1 151 ? -64.826 -12.247 -3.013  1.00 69.06  ? 155 GLU A OE2 1 
ATOM   1145 N N   . PHE A 1 152 ? -63.452 -10.156 -6.593  1.00 48.95  ? 156 PHE A N   1 
ATOM   1146 C CA  . PHE A 1 152 ? -63.131 -8.839  -7.206  1.00 48.62  ? 156 PHE A CA  1 
ATOM   1147 C C   . PHE A 1 152 ? -62.022 -8.150  -6.367  1.00 43.95  ? 156 PHE A C   1 
ATOM   1148 O O   . PHE A 1 152 ? -62.322 -7.480  -5.348  1.00 45.81  ? 156 PHE A O   1 
ATOM   1149 C CB  . PHE A 1 152 ? -64.430 -8.036  -7.317  1.00 49.77  ? 156 PHE A CB  1 
ATOM   1150 C CG  . PHE A 1 152 ? -64.373 -6.795  -8.179  1.00 55.86  ? 156 PHE A CG  1 
ATOM   1151 C CD1 . PHE A 1 152 ? -63.171 -6.323  -8.709  1.00 57.38  ? 156 PHE A CD1 1 
ATOM   1152 C CD2 . PHE A 1 152 ? -65.540 -6.085  -8.444  1.00 55.93  ? 156 PHE A CD2 1 
ATOM   1153 C CE1 . PHE A 1 152 ? -63.144 -5.169  -9.487  1.00 60.72  ? 156 PHE A CE1 1 
ATOM   1154 C CE2 . PHE A 1 152 ? -65.511 -4.940  -9.229  1.00 58.32  ? 156 PHE A CE2 1 
ATOM   1155 C CZ  . PHE A 1 152 ? -64.316 -4.491  -9.759  1.00 61.75  ? 156 PHE A CZ  1 
ATOM   1156 N N   . VAL A 1 153 ? -60.761 -8.379  -6.722  1.00 37.97  ? 157 VAL A N   1 
ATOM   1157 C CA  . VAL A 1 153 ? -59.591 -7.917  -5.924  1.00 44.56  ? 157 VAL A CA  1 
ATOM   1158 C C   . VAL A 1 153 ? -58.948 -6.661  -6.558  1.00 45.12  ? 157 VAL A C   1 
ATOM   1159 O O   . VAL A 1 153 ? -58.976 -6.544  -7.775  1.00 39.16  ? 157 VAL A O   1 
ATOM   1160 C CB  . VAL A 1 153 ? -58.531 -9.016  -5.774  1.00 41.10  ? 157 VAL A CB  1 
ATOM   1161 C CG1 . VAL A 1 153 ? -59.007 -10.081 -4.806  1.00 48.41  ? 157 VAL A CG1 1 
ATOM   1162 C CG2 . VAL A 1 153 ? -58.120 -9.592  -7.109  1.00 42.92  ? 157 VAL A CG2 1 
ATOM   1163 N N   . VAL A 1 154 ? -58.369 -5.794  -5.710  1.00 41.16  ? 158 VAL A N   1 
ATOM   1164 C CA  . VAL A 1 154 ? -57.588 -4.588  -6.096  1.00 44.14  ? 158 VAL A CA  1 
ATOM   1165 C C   . VAL A 1 154 ? -56.399 -4.471  -5.151  1.00 41.27  ? 158 VAL A C   1 
ATOM   1166 O O   . VAL A 1 154 ? -56.359 -5.133  -4.051  1.00 40.12  ? 158 VAL A O   1 
ATOM   1167 C CB  . VAL A 1 154 ? -58.440 -3.302  -6.067  1.00 41.58  ? 158 VAL A CB  1 
ATOM   1168 C CG1 . VAL A 1 154 ? -59.384 -3.233  -7.235  1.00 42.37  ? 158 VAL A CG1 1 
ATOM   1169 C CG2 . VAL A 1 154 ? -59.180 -3.112  -4.758  1.00 40.52  ? 158 VAL A CG2 1 
ATOM   1170 N N   . GLY A 1 155 ? -55.432 -3.652  -5.548  1.00 39.43  ? 159 GLY A N   1 
ATOM   1171 C CA  . GLY A 1 155 ? -54.345 -3.276  -4.639  1.00 36.13  ? 159 GLY A CA  1 
ATOM   1172 C C   . GLY A 1 155 ? -53.069 -3.986  -4.966  1.00 39.78  ? 159 GLY A C   1 
ATOM   1173 O O   . GLY A 1 155 ? -53.092 -4.907  -5.795  1.00 39.74  ? 159 GLY A O   1 
ATOM   1174 N N   . TYR A 1 156 ? -51.951 -3.492  -4.438  1.00 37.78  ? 160 TYR A N   1 
ATOM   1175 C CA  . TYR A 1 156 ? -50.640 -4.172  -4.587  1.00 37.83  ? 160 TYR A CA  1 
ATOM   1176 C C   . TYR A 1 156 ? -50.378 -4.425  -6.084  1.00 37.05  ? 160 TYR A C   1 
ATOM   1177 O O   . TYR A 1 156 ? -49.817 -5.474  -6.499  1.00 39.36  ? 160 TYR A O   1 
ATOM   1178 C CB  . TYR A 1 156 ? -50.668 -5.433  -3.711  1.00 38.23  ? 160 TYR A CB  1 
ATOM   1179 C CG  . TYR A 1 156 ? -49.292 -5.806  -3.269  1.00 34.62  ? 160 TYR A CG  1 
ATOM   1180 C CD1 . TYR A 1 156 ? -48.665 -5.194  -2.199  1.00 38.81  ? 160 TYR A CD1 1 
ATOM   1181 C CD2 . TYR A 1 156 ? -48.593 -6.734  -3.976  1.00 38.70  ? 160 TYR A CD2 1 
ATOM   1182 C CE1 . TYR A 1 156 ? -47.380 -5.529  -1.832  1.00 35.83  ? 160 TYR A CE1 1 
ATOM   1183 C CE2 . TYR A 1 156 ? -47.313 -7.081  -3.622  1.00 40.08  ? 160 TYR A CE2 1 
ATOM   1184 C CZ  . TYR A 1 156 ? -46.678 -6.425  -2.595  1.00 36.20  ? 160 TYR A CZ  1 
ATOM   1185 O OH  . TYR A 1 156 ? -45.384 -6.797  -2.334  1.00 39.70  ? 160 TYR A OH  1 
ATOM   1186 N N   . GLY A 1 157 ? -50.706 -3.408  -6.888  1.00 37.61  ? 161 GLY A N   1 
ATOM   1187 C CA  . GLY A 1 157 ? -50.429 -3.349  -8.335  1.00 38.98  ? 161 GLY A CA  1 
ATOM   1188 C C   . GLY A 1 157 ? -51.666 -3.621  -9.165  1.00 40.44  ? 161 GLY A C   1 
ATOM   1189 O O   . GLY A 1 157 ? -51.653 -3.312  -10.355 1.00 39.15  ? 161 GLY A O   1 
ATOM   1190 N N   . ILE A 1 158 ? -52.718 -4.180  -8.556  1.00 39.48  ? 162 ILE A N   1 
ATOM   1191 C CA  . ILE A 1 158 ? -53.979 -4.491  -9.275  1.00 37.46  ? 162 ILE A CA  1 
ATOM   1192 C C   . ILE A 1 158 ? -54.885 -3.277  -9.225  1.00 40.89  ? 162 ILE A C   1 
ATOM   1193 O O   . ILE A 1 158 ? -55.211 -2.794  -8.131  1.00 38.43  ? 162 ILE A O   1 
ATOM   1194 C CB  . ILE A 1 158 ? -54.645 -5.761  -8.726  1.00 40.97  ? 162 ILE A CB  1 
ATOM   1195 C CG1 . ILE A 1 158 ? -53.656 -6.927  -8.781  1.00 45.41  ? 162 ILE A CG1 1 
ATOM   1196 C CG2 . ILE A 1 158 ? -55.914 -6.069  -9.494  1.00 46.98  ? 162 ILE A CG2 1 
ATOM   1197 C CD1 . ILE A 1 158 ? -54.053 -8.106  -7.926  1.00 52.56  ? 162 ILE A CD1 1 
ATOM   1198 N N   . ASP A 1 159 ? -55.289 -2.818  -10.408 1.00 42.66  ? 163 ASP A N   1 
ATOM   1199 C CA  . ASP A 1 159 ? -56.133 -1.615  -10.577 1.00 43.60  ? 163 ASP A CA  1 
ATOM   1200 C C   . ASP A 1 159 ? -57.592 -2.027  -10.732 1.00 43.77  ? 163 ASP A C   1 
ATOM   1201 O O   . ASP A 1 159 ? -57.853 -3.113  -11.141 1.00 43.31  ? 163 ASP A O   1 
ATOM   1202 C CB  . ASP A 1 159 ? -55.708 -0.812  -11.815 1.00 45.18  ? 163 ASP A CB  1 
ATOM   1203 C CG  . ASP A 1 159 ? -56.008 -1.528  -13.129 1.00 49.39  ? 163 ASP A CG  1 
ATOM   1204 O OD1 . ASP A 1 159 ? -55.377 -2.572  -13.428 1.00 56.78  ? 163 ASP A OD1 1 
ATOM   1205 O OD2 . ASP A 1 159 ? -56.890 -1.076  -13.807 1.00 62.58  ? 163 ASP A OD2 1 
ATOM   1206 N N   . TYR A 1 160 ? -58.501 -1.120  -10.441 1.00 46.43  ? 164 TYR A N   1 
ATOM   1207 C CA  . TYR A 1 160 ? -59.887 -1.087  -10.962 1.00 50.29  ? 164 TYR A CA  1 
ATOM   1208 C C   . TYR A 1 160 ? -60.174 0.334   -11.467 1.00 51.35  ? 164 TYR A C   1 
ATOM   1209 O O   . TYR A 1 160 ? -60.198 1.271   -10.590 1.00 48.82  ? 164 TYR A O   1 
ATOM   1210 C CB  . TYR A 1 160 ? -60.860 -1.441  -9.850  1.00 50.18  ? 164 TYR A CB  1 
ATOM   1211 C CG  . TYR A 1 160 ? -62.306 -1.158  -10.161 1.00 58.35  ? 164 TYR A CG  1 
ATOM   1212 C CD1 . TYR A 1 160 ? -62.861 -1.481  -11.391 1.00 56.46  ? 164 TYR A CD1 1 
ATOM   1213 C CD2 . TYR A 1 160 ? -63.115 -0.573  -9.201  1.00 54.07  ? 164 TYR A CD2 1 
ATOM   1214 C CE1 . TYR A 1 160 ? -64.201 -1.239  -11.654 1.00 59.05  ? 164 TYR A CE1 1 
ATOM   1215 C CE2 . TYR A 1 160 ? -64.451 -0.335  -9.444  1.00 65.95  ? 164 TYR A CE2 1 
ATOM   1216 C CZ  . TYR A 1 160 ? -64.997 -0.673  -10.671 1.00 61.10  ? 164 TYR A CZ  1 
ATOM   1217 O OH  . TYR A 1 160 ? -66.324 -0.419  -10.861 1.00 71.63  ? 164 TYR A OH  1 
ATOM   1218 N N   . ALA A 1 161 ? -60.316 0.511   -12.786 1.00 54.02  ? 165 ALA A N   1 
ATOM   1219 C CA  . ALA A 1 161 ? -60.659 1.822   -13.403 1.00 66.90  ? 165 ALA A CA  1 
ATOM   1220 C C   . ALA A 1 161 ? -59.583 2.858   -13.035 1.00 59.73  ? 165 ALA A C   1 
ATOM   1221 O O   . ALA A 1 161 ? -59.947 3.888   -12.412 1.00 59.78  ? 165 ALA A O   1 
ATOM   1222 C CB  . ALA A 1 161 ? -62.023 2.273   -12.914 1.00 64.63  ? 165 ALA A CB  1 
ATOM   1223 N N   . GLN A 1 162 ? -58.316 2.519   -13.291 1.00 71.97  ? 166 GLN A N   1 
ATOM   1224 C CA  . GLN A 1 162 ? -57.109 3.330   -12.952 1.00 79.84  ? 166 GLN A CA  1 
ATOM   1225 C C   . GLN A 1 162 ? -57.161 3.816   -11.485 1.00 76.63  ? 166 GLN A C   1 
ATOM   1226 O O   . GLN A 1 162 ? -56.766 4.959   -11.188 1.00 81.43  ? 166 GLN A O   1 
ATOM   1227 C CB  . GLN A 1 162 ? -56.984 4.446   -14.001 1.00 84.24  ? 166 GLN A CB  1 
ATOM   1228 C CG  . GLN A 1 162 ? -56.415 3.965   -15.336 1.00 86.73  ? 166 GLN A CG  1 
ATOM   1229 C CD  . GLN A 1 162 ? -55.041 3.319   -15.234 1.00 105.02 ? 166 GLN A CD  1 
ATOM   1230 O OE1 . GLN A 1 162 ? -54.033 3.945   -14.849 1.00 106.36 ? 166 GLN A OE1 1 
ATOM   1231 N NE2 . GLN A 1 162 ? -54.984 2.045   -15.614 1.00 66.39  ? 166 GLN A NE2 1 
ATOM   1232 N N   . ARG A 1 163 ? -57.605 2.968   -10.567 1.00 62.21  ? 167 ARG A N   1 
ATOM   1233 C CA  . ARG A 1 163 ? -57.676 3.279   -9.116  1.00 59.90  ? 167 ARG A CA  1 
ATOM   1234 C C   . ARG A 1 163 ? -57.045 2.097   -8.363  1.00 51.87  ? 167 ARG A C   1 
ATOM   1235 O O   . ARG A 1 163 ? -57.070 0.958   -8.912  1.00 43.15  ? 167 ARG A O   1 
ATOM   1236 C CB  . ARG A 1 163 ? -59.140 3.558   -8.752  1.00 64.17  ? 167 ARG A CB  1 
ATOM   1237 C CG  . ARG A 1 163 ? -59.366 4.772   -7.868  1.00 71.02  ? 167 ARG A CG  1 
ATOM   1238 C CD  . ARG A 1 163 ? -60.818 5.239   -7.785  1.00 78.74  ? 167 ARG A CD  1 
ATOM   1239 N NE  . ARG A 1 163 ? -61.089 5.884   -6.493  1.00 94.56  ? 167 ARG A NE  1 
ATOM   1240 C CZ  . ARG A 1 163 ? -62.292 6.042   -5.912  1.00 98.84  ? 167 ARG A CZ  1 
ATOM   1241 N NH1 . ARG A 1 163 ? -63.407 5.626   -6.493  1.00 96.81  ? 167 ARG A NH1 1 
ATOM   1242 N NH2 . ARG A 1 163 ? -62.376 6.625   -4.729  1.00 92.52  ? 167 ARG A NH2 1 
ATOM   1243 N N   . TYR A 1 164 ? -56.448 2.378   -7.201  1.00 48.33  ? 168 TYR A N   1 
ATOM   1244 C CA  . TYR A 1 164 ? -56.045 1.414   -6.142  1.00 44.94  ? 168 TYR A CA  1 
ATOM   1245 C C   . TYR A 1 164 ? -54.769 0.651   -6.457  1.00 36.45  ? 168 TYR A C   1 
ATOM   1246 O O   . TYR A 1 164 ? -54.432 -0.174  -5.629  1.00 40.73  ? 168 TYR A O   1 
ATOM   1247 C CB  . TYR A 1 164 ? -57.151 0.386   -5.878  1.00 44.11  ? 168 TYR A CB  1 
ATOM   1248 C CG  . TYR A 1 164 ? -58.497 1.015   -5.611  1.00 44.99  ? 168 TYR A CG  1 
ATOM   1249 C CD1 . TYR A 1 164 ? -58.667 1.905   -4.565  1.00 47.47  ? 168 TYR A CD1 1 
ATOM   1250 C CD2 . TYR A 1 164 ? -59.576 0.771   -6.436  1.00 48.28  ? 168 TYR A CD2 1 
ATOM   1251 C CE1 . TYR A 1 164 ? -59.882 2.525   -4.333  1.00 48.75  ? 168 TYR A CE1 1 
ATOM   1252 C CE2 . TYR A 1 164 ? -60.807 1.359   -6.205  1.00 50.68  ? 168 TYR A CE2 1 
ATOM   1253 C CZ  . TYR A 1 164 ? -60.961 2.232   -5.143  1.00 50.91  ? 168 TYR A CZ  1 
ATOM   1254 O OH  . TYR A 1 164 ? -62.170 2.821   -4.913  1.00 56.18  ? 168 TYR A OH  1 
ATOM   1255 N N   . ARG A 1 165 ? -54.036 0.922   -7.529  1.00 36.90  ? 169 ARG A N   1 
ATOM   1256 C CA  . ARG A 1 165 ? -52.734 0.238   -7.737  1.00 40.15  ? 169 ARG A CA  1 
ATOM   1257 C C   . ARG A 1 165 ? -51.799 0.422   -6.551  1.00 37.62  ? 169 ARG A C   1 
ATOM   1258 O O   . ARG A 1 165 ? -50.927 -0.447  -6.338  1.00 36.17  ? 169 ARG A O   1 
ATOM   1259 C CB  . ARG A 1 165 ? -51.962 0.786   -8.935  1.00 42.34  ? 169 ARG A CB  1 
ATOM   1260 C CG  . ARG A 1 165 ? -52.283 0.109   -10.248 1.00 42.34  ? 169 ARG A CG  1 
ATOM   1261 C CD  . ARG A 1 165 ? -51.385 0.604   -11.331 1.00 46.41  ? 169 ARG A CD  1 
ATOM   1262 N NE  . ARG A 1 165 ? -52.220 0.648   -12.494 1.00 43.07  ? 169 ARG A NE  1 
ATOM   1263 C CZ  . ARG A 1 165 ? -52.397 -0.366  -13.318 1.00 41.44  ? 169 ARG A CZ  1 
ATOM   1264 N NH1 . ARG A 1 165 ? -51.789 -1.522  -13.097 1.00 43.77  ? 169 ARG A NH1 1 
ATOM   1265 N NH2 . ARG A 1 165 ? -53.161 -0.203  -14.364 1.00 42.32  ? 169 ARG A NH2 1 
ATOM   1266 N N   . HIS A 1 166 ? -51.900 1.561   -5.871  1.00 36.93  ? 170 HIS A N   1 
ATOM   1267 C CA  . HIS A 1 166 ? -50.951 1.994   -4.818  1.00 36.93  ? 170 HIS A CA  1 
ATOM   1268 C C   . HIS A 1 166 ? -51.370 1.480   -3.432  1.00 39.89  ? 170 HIS A C   1 
ATOM   1269 O O   . HIS A 1 166 ? -50.576 1.663   -2.458  1.00 45.14  ? 170 HIS A O   1 
ATOM   1270 C CB  . HIS A 1 166 ? -50.785 3.535   -4.875  1.00 34.23  ? 170 HIS A CB  1 
ATOM   1271 C CG  . HIS A 1 166 ? -52.078 4.247   -4.760  1.00 33.24  ? 170 HIS A CG  1 
ATOM   1272 N ND1 . HIS A 1 166 ? -52.631 4.553   -3.555  1.00 36.02  ? 170 HIS A ND1 1 
ATOM   1273 C CD2 . HIS A 1 166 ? -52.972 4.629   -5.698  1.00 40.09  ? 170 HIS A CD2 1 
ATOM   1274 C CE1 . HIS A 1 166 ? -53.801 5.150   -3.757  1.00 44.41  ? 170 HIS A CE1 1 
ATOM   1275 N NE2 . HIS A 1 166 ? -54.045 5.180   -5.079  1.00 41.83  ? 170 HIS A NE2 1 
ATOM   1276 N N   . LEU A 1 167 ? -52.501 0.780   -3.277  1.00 46.45  ? 171 LEU A N   1 
ATOM   1277 C CA  . LEU A 1 167 ? -52.886 0.218   -1.931  1.00 37.15  ? 171 LEU A CA  1 
ATOM   1278 C C   . LEU A 1 167 ? -51.817 -0.752  -1.470  1.00 37.11  ? 171 LEU A C   1 
ATOM   1279 O O   . LEU A 1 167 ? -51.313 -1.534  -2.257  1.00 36.03  ? 171 LEU A O   1 
ATOM   1280 C CB  . LEU A 1 167 ? -54.240 -0.488  -1.986  1.00 42.38  ? 171 LEU A CB  1 
ATOM   1281 C CG  . LEU A 1 167 ? -55.432 0.384   -2.337  1.00 42.86  ? 171 LEU A CG  1 
ATOM   1282 C CD1 . LEU A 1 167 ? -56.726 -0.417  -2.247  1.00 43.24  ? 171 LEU A CD1 1 
ATOM   1283 C CD2 . LEU A 1 167 ? -55.503 1.622   -1.432  1.00 44.46  ? 171 LEU A CD2 1 
ATOM   1284 N N   . PRO A 1 168 ? -51.373 -0.704  -0.198  1.00 34.13  ? 172 PRO A N   1 
ATOM   1285 C CA  . PRO A 1 168 ? -50.408 -1.662  0.317   1.00 38.67  ? 172 PRO A CA  1 
ATOM   1286 C C   . PRO A 1 168 ? -50.987 -3.016  0.788   1.00 36.75  ? 172 PRO A C   1 
ATOM   1287 O O   . PRO A 1 168 ? -50.215 -3.808  1.307   1.00 36.17  ? 172 PRO A O   1 
ATOM   1288 C CB  . PRO A 1 168 ? -49.855 -0.947  1.560   1.00 35.21  ? 172 PRO A CB  1 
ATOM   1289 C CG  . PRO A 1 168 ? -51.043 -0.183  2.014   1.00 35.46  ? 172 PRO A CG  1 
ATOM   1290 C CD  . PRO A 1 168 ? -51.718 0.327   0.763   1.00 35.95  ? 172 PRO A CD  1 
ATOM   1291 N N   . TYR A 1 169 ? -52.273 -3.223  0.618   1.00 39.59  ? 173 TYR A N   1 
ATOM   1292 C CA  . TYR A 1 169 ? -52.985 -4.495  0.931   1.00 44.00  ? 173 TYR A CA  1 
ATOM   1293 C C   . TYR A 1 169 ? -53.789 -4.938  -0.294  1.00 45.84  ? 173 TYR A C   1 
ATOM   1294 O O   . TYR A 1 169 ? -54.040 -4.127  -1.191  1.00 41.48  ? 173 TYR A O   1 
ATOM   1295 C CB  . TYR A 1 169 ? -53.946 -4.301  2.107   1.00 40.36  ? 173 TYR A CB  1 
ATOM   1296 C CG  . TYR A 1 169 ? -54.934 -3.176  1.930   1.00 40.31  ? 173 TYR A CG  1 
ATOM   1297 C CD1 . TYR A 1 169 ? -56.167 -3.409  1.366   1.00 39.16  ? 173 TYR A CD1 1 
ATOM   1298 C CD2 . TYR A 1 169 ? -54.659 -1.887  2.369   1.00 44.15  ? 173 TYR A CD2 1 
ATOM   1299 C CE1 . TYR A 1 169 ? -57.073 -2.391  1.166   1.00 46.79  ? 173 TYR A CE1 1 
ATOM   1300 C CE2 . TYR A 1 169 ? -55.566 -0.851  2.191   1.00 42.29  ? 173 TYR A CE2 1 
ATOM   1301 C CZ  . TYR A 1 169 ? -56.776 -1.106  1.587   1.00 45.64  ? 173 TYR A CZ  1 
ATOM   1302 O OH  . TYR A 1 169 ? -57.733 -0.151  1.430   1.00 47.48  ? 173 TYR A OH  1 
ATOM   1303 N N   . ILE A 1 170 ? -54.232 -6.187  -0.302  1.00 41.96  ? 174 ILE A N   1 
ATOM   1304 C CA  . ILE A 1 170 ? -55.233 -6.658  -1.284  1.00 40.82  ? 174 ILE A CA  1 
ATOM   1305 C C   . ILE A 1 170 ? -56.608 -6.368  -0.731  1.00 39.19  ? 174 ILE A C   1 
ATOM   1306 O O   . ILE A 1 170 ? -56.939 -6.812  0.378   1.00 41.33  ? 174 ILE A O   1 
ATOM   1307 C CB  . ILE A 1 170 ? -55.023 -8.147  -1.600  1.00 41.95  ? 174 ILE A CB  1 
ATOM   1308 C CG1 . ILE A 1 170 ? -53.618 -8.383  -2.147  1.00 40.71  ? 174 ILE A CG1 1 
ATOM   1309 C CG2 . ILE A 1 170 ? -56.121 -8.640  -2.541  1.00 40.20  ? 174 ILE A CG2 1 
ATOM   1310 C CD1 . ILE A 1 170 ? -53.441 -7.875  -3.549  1.00 45.54  ? 174 ILE A CD1 1 
ATOM   1311 N N   . GLY A 1 171 ? -57.403 -5.659  -1.506  1.00 41.99  ? 175 GLY A N   1 
ATOM   1312 C CA  . GLY A 1 171 ? -58.774 -5.306  -1.111  1.00 40.05  ? 175 GLY A CA  1 
ATOM   1313 C C   . GLY A 1 171 ? -59.789 -6.069  -1.938  1.00 45.08  ? 175 GLY A C   1 
ATOM   1314 O O   . GLY A 1 171 ? -59.434 -6.503  -3.031  1.00 39.98  ? 175 GLY A O   1 
ATOM   1315 N N   . LYS A 1 172 ? -61.013 -6.189  -1.425  1.00 45.41  ? 176 LYS A N   1 
ATOM   1316 C CA  . LYS A 1 172 ? -62.202 -6.694  -2.149  1.00 50.30  ? 176 LYS A CA  1 
ATOM   1317 C C   . LYS A 1 172 ? -63.056 -5.481  -2.490  1.00 46.98  ? 176 LYS A C   1 
ATOM   1318 O O   . LYS A 1 172 ? -63.313 -4.691  -1.580  1.00 48.87  ? 176 LYS A O   1 
ATOM   1319 C CB  . LYS A 1 172 ? -62.997 -7.656  -1.259  1.00 50.23  ? 176 LYS A CB  1 
ATOM   1320 C CG  . LYS A 1 172 ? -64.158 -8.373  -1.931  1.00 59.31  ? 176 LYS A CG  1 
ATOM   1321 C CD  . LYS A 1 172 ? -65.094 -9.007  -0.919  1.00 64.93  ? 176 LYS A CD  1 
ATOM   1322 C CE  . LYS A 1 172 ? -66.487 -9.278  -1.451  1.00 68.50  ? 176 LYS A CE  1 
ATOM   1323 N NZ  . LYS A 1 172 ? -66.628 -10.689 -1.873  1.00 74.95  ? 176 LYS A NZ  1 
ATOM   1324 N N   . VAL A 1 173 ? -63.444 -5.352  -3.757  1.00 49.15  ? 177 VAL A N   1 
ATOM   1325 C CA  . VAL A 1 173 ? -64.413 -4.336  -4.241  1.00 56.31  ? 177 VAL A CA  1 
ATOM   1326 C C   . VAL A 1 173 ? -65.826 -4.898  -4.065  1.00 64.42  ? 177 VAL A C   1 
ATOM   1327 O O   . VAL A 1 173 ? -66.089 -5.989  -4.609  1.00 59.87  ? 177 VAL A O   1 
ATOM   1328 C CB  . VAL A 1 173 ? -64.138 -3.981  -5.710  1.00 52.45  ? 177 VAL A CB  1 
ATOM   1329 C CG1 . VAL A 1 173 ? -65.077 -2.917  -6.231  1.00 59.45  ? 177 VAL A CG1 1 
ATOM   1330 C CG2 . VAL A 1 173 ? -62.699 -3.561  -5.888  1.00 53.60  ? 177 VAL A CG2 1 
ATOM   1331 N N   . ILE A 1 174 ? -66.677 -4.154  -3.355  1.00 64.81  ? 178 ILE A N   1 
ATOM   1332 C CA  . ILE A 1 174 ? -68.138 -4.399  -3.170  1.00 74.59  ? 178 ILE A CA  1 
ATOM   1333 C C   . ILE A 1 174 ? -68.887 -3.477  -4.136  1.00 72.42  ? 178 ILE A C   1 
ATOM   1334 O O   . ILE A 1 174 ? -68.855 -2.244  -3.890  1.00 65.53  ? 178 ILE A O   1 
ATOM   1335 C CB  . ILE A 1 174 ? -68.552 -4.060  -1.716  1.00 79.02  ? 178 ILE A CB  1 
ATOM   1336 C CG1 . ILE A 1 174 ? -67.551 -4.546  -0.660  1.00 79.81  ? 178 ILE A CG1 1 
ATOM   1337 C CG2 . ILE A 1 174 ? -69.969 -4.531  -1.421  1.00 85.85  ? 178 ILE A CG2 1 
ATOM   1338 C CD1 . ILE A 1 174 ? -67.308 -6.028  -0.665  1.00 78.09  ? 178 ILE A CD1 1 
ATOM   1339 N N   . LEU A 1 175 ? -69.541 -3.995  -5.175  1.00 78.05  ? 179 LEU A N   1 
ATOM   1340 C CA  . LEU A 1 175 ? -70.410 -3.158  -6.061  1.00 76.84  ? 179 LEU A CA  1 
ATOM   1341 C C   . LEU A 1 175 ? -71.660 -2.706  -5.281  1.00 85.36  ? 179 LEU A C   1 
ATOM   1342 O O   . LEU A 1 175 ? -72.294 -3.568  -4.659  1.00 92.78  ? 179 LEU A O   1 
ATOM   1343 C CB  . LEU A 1 175 ? -70.817 -3.954  -7.304  1.00 81.73  ? 179 LEU A CB  1 
ATOM   1344 C CG  . LEU A 1 175 ? -69.776 -4.132  -8.415  1.00 79.62  ? 179 LEU A CG  1 
ATOM   1345 C CD1 . LEU A 1 175 ? -68.859 -2.920  -8.542  1.00 83.33  ? 179 LEU A CD1 1 
ATOM   1346 C CD2 . LEU A 1 175 ? -68.982 -5.410  -8.211  1.00 82.75  ? 179 LEU A CD2 1 
ATOM   1347 N N   . LEU A 1 176 ? -71.984 -1.405  -5.291  1.00 91.11  ? 180 LEU A N   1 
ATOM   1348 C CA  . LEU A 1 176 ? -73.193 -0.817  -4.646  1.00 99.08  ? 180 LEU A CA  1 
ATOM   1349 C C   . LEU A 1 176 ? -74.168 -0.404  -5.751  1.00 91.66  ? 180 LEU A C   1 
ATOM   1350 O O   . LEU A 1 176 ? -75.338 -0.701  -5.623  1.00 97.76  ? 180 LEU A O   1 
ATOM   1351 C CB  . LEU A 1 176 ? -72.808 0.391   -3.778  1.00 103.00 ? 180 LEU A CB  1 
ATOM   1352 C CG  . LEU A 1 176 ? -71.798 0.129   -2.655  1.00 110.45 ? 180 LEU A CG  1 
ATOM   1353 C CD1 . LEU A 1 176 ? -71.404 1.423   -1.948  1.00 106.20 ? 180 LEU A CD1 1 
ATOM   1354 C CD2 . LEU A 1 176 ? -72.335 -0.882  -1.648  1.00 111.06 ? 180 LEU A CD2 1 
ATOM   1355 N N   . LYS B 1 2   ? -13.097 -5.420  -10.026 1.00 69.13  ? 6   LYS B N   1 
ATOM   1356 C CA  . LYS B 1 2   ? -12.964 -5.891  -8.597  1.00 73.83  ? 6   LYS B CA  1 
ATOM   1357 C C   . LYS B 1 2   ? -13.310 -4.708  -7.673  1.00 76.74  ? 6   LYS B C   1 
ATOM   1358 O O   . LYS B 1 2   ? -12.852 -3.581  -7.935  1.00 83.67  ? 6   LYS B O   1 
ATOM   1359 C CB  . LYS B 1 2   ? -11.578 -6.498  -8.318  1.00 62.67  ? 6   LYS B CB  1 
ATOM   1360 N N   . HIS B 1 3   ? -14.125 -4.944  -6.643  1.00 77.63  ? 7   HIS B N   1 
ATOM   1361 C CA  . HIS B 1 3   ? -14.757 -3.882  -5.809  1.00 73.95  ? 7   HIS B CA  1 
ATOM   1362 C C   . HIS B 1 3   ? -15.396 -4.500  -4.557  1.00 67.89  ? 7   HIS B C   1 
ATOM   1363 O O   . HIS B 1 3   ? -15.478 -5.729  -4.465  1.00 61.50  ? 7   HIS B O   1 
ATOM   1364 C CB  . HIS B 1 3   ? -15.798 -3.107  -6.641  1.00 74.97  ? 7   HIS B CB  1 
ATOM   1365 C CG  . HIS B 1 3   ? -16.993 -3.939  -6.968  1.00 72.44  ? 7   HIS B CG  1 
ATOM   1366 N ND1 . HIS B 1 3   ? -17.049 -4.729  -8.098  1.00 68.53  ? 7   HIS B ND1 1 
ATOM   1367 C CD2 . HIS B 1 3   ? -18.128 -4.181  -6.270  1.00 69.15  ? 7   HIS B CD2 1 
ATOM   1368 C CE1 . HIS B 1 3   ? -18.174 -5.411  -8.095  1.00 65.87  ? 7   HIS B CE1 1 
ATOM   1369 N NE2 . HIS B 1 3   ? -18.855 -5.094  -6.982  1.00 67.52  ? 7   HIS B NE2 1 
ATOM   1370 N N   . THR B 1 4   ? -15.799 -3.670  -3.601  1.00 68.88  ? 8   THR B N   1 
ATOM   1371 C CA  . THR B 1 4   ? -16.787 -4.037  -2.557  1.00 69.14  ? 8   THR B CA  1 
ATOM   1372 C C   . THR B 1 4   ? -17.907 -2.994  -2.571  1.00 65.17  ? 8   THR B C   1 
ATOM   1373 O O   . THR B 1 4   ? -17.750 -1.899  -3.197  1.00 60.41  ? 8   THR B O   1 
ATOM   1374 C CB  . THR B 1 4   ? -16.200 -4.119  -1.142  1.00 72.70  ? 8   THR B CB  1 
ATOM   1375 O OG1 . THR B 1 4   ? -15.628 -2.830  -0.919  1.00 79.18  ? 8   THR B OG1 1 
ATOM   1376 C CG2 . THR B 1 4   ? -15.194 -5.236  -0.948  1.00 76.07  ? 8   THR B CG2 1 
ATOM   1377 N N   . VAL B 1 5   ? -18.994 -3.325  -1.888  1.00 58.21  ? 9   VAL B N   1 
ATOM   1378 C CA  . VAL B 1 5   ? -20.123 -2.392  -1.666  1.00 62.67  ? 9   VAL B CA  1 
ATOM   1379 C C   . VAL B 1 5   ? -20.152 -2.098  -0.180  1.00 58.37  ? 9   VAL B C   1 
ATOM   1380 O O   . VAL B 1 5   ? -20.223 -3.056  0.575   1.00 63.75  ? 9   VAL B O   1 
ATOM   1381 C CB  . VAL B 1 5   ? -21.463 -2.974  -2.138  1.00 60.37  ? 9   VAL B CB  1 
ATOM   1382 C CG1 . VAL B 1 5   ? -22.584 -2.011  -1.787  1.00 58.71  ? 9   VAL B CG1 1 
ATOM   1383 C CG2 . VAL B 1 5   ? -21.437 -3.321  -3.628  1.00 57.71  ? 9   VAL B CG2 1 
ATOM   1384 N N   . GLU B 1 6   ? -20.095 -0.827  0.192   1.00 59.86  ? 10  GLU B N   1 
ATOM   1385 C CA  . GLU B 1 6   ? -20.345 -0.374  1.579   1.00 63.52  ? 10  GLU B CA  1 
ATOM   1386 C C   . GLU B 1 6   ? -21.781 0.146   1.618   1.00 57.22  ? 10  GLU B C   1 
ATOM   1387 O O   . GLU B 1 6   ? -22.192 0.797   0.628   1.00 62.55  ? 10  GLU B O   1 
ATOM   1388 C CB  . GLU B 1 6   ? -19.410 0.774   1.974   1.00 73.61  ? 10  GLU B CB  1 
ATOM   1389 C CG  . GLU B 1 6   ? -17.997 0.381   2.404   1.00 82.76  ? 10  GLU B CG  1 
ATOM   1390 C CD  . GLU B 1 6   ? -17.044 1.578   2.516   1.00 86.42  ? 10  GLU B CD  1 
ATOM   1391 O OE1 . GLU B 1 6   ? -17.471 2.644   3.012   1.00 82.22  ? 10  GLU B OE1 1 
ATOM   1392 O OE2 . GLU B 1 6   ? -15.887 1.471   2.065   1.00 96.50  ? 10  GLU B OE2 1 
ATOM   1393 N N   . VAL B 1 7   ? -22.491 -0.083  2.725   1.00 59.90  ? 11  VAL B N   1 
ATOM   1394 C CA  . VAL B 1 7   ? -23.749 0.643   3.068   1.00 58.34  ? 11  VAL B CA  1 
ATOM   1395 C C   . VAL B 1 7   ? -23.409 2.129   3.101   1.00 55.06  ? 11  VAL B C   1 
ATOM   1396 O O   . VAL B 1 7   ? -22.440 2.438   3.747   1.00 56.85  ? 11  VAL B O   1 
ATOM   1397 C CB  . VAL B 1 7   ? -24.354 0.231   4.420   1.00 58.36  ? 11  VAL B CB  1 
ATOM   1398 C CG1 . VAL B 1 7   ? -25.541 1.123   4.772   1.00 54.70  ? 11  VAL B CG1 1 
ATOM   1399 C CG2 . VAL B 1 7   ? -24.719 -1.238  4.463   1.00 58.53  ? 11  VAL B CG2 1 
ATOM   1400 N N   . MET B 1 8   ? -24.199 2.965   2.426   1.00 48.95  ? 12  MET B N   1 
ATOM   1401 C CA  . MET B 1 8   ? -24.114 4.438   2.424   1.00 51.81  ? 12  MET B CA  1 
ATOM   1402 C C   . MET B 1 8   ? -25.374 4.992   3.065   1.00 52.02  ? 12  MET B C   1 
ATOM   1403 O O   . MET B 1 8   ? -25.214 5.866   3.873   1.00 59.74  ? 12  MET B O   1 
ATOM   1404 C CB  . MET B 1 8   ? -23.980 5.000   1.008   1.00 56.77  ? 12  MET B CB  1 
ATOM   1405 C CG  . MET B 1 8   ? -23.758 6.510   0.949   1.00 60.43  ? 12  MET B CG  1 
ATOM   1406 S SD  . MET B 1 8   ? -23.644 7.129   -0.765  1.00 62.73  ? 12  MET B SD  1 
ATOM   1407 C CE  . MET B 1 8   ? -24.619 8.624   -0.643  1.00 63.56  ? 12  MET B CE  1 
ATOM   1408 N N   . ILE B 1 9   ? -26.578 4.543   2.680   1.00 47.47  ? 13  ILE B N   1 
ATOM   1409 C CA  . ILE B 1 9   ? -27.852 4.991   3.327   1.00 45.22  ? 13  ILE B CA  1 
ATOM   1410 C C   . ILE B 1 9   ? -28.623 3.730   3.703   1.00 57.65  ? 13  ILE B C   1 
ATOM   1411 O O   . ILE B 1 9   ? -29.108 3.007   2.817   1.00 47.12  ? 13  ILE B O   1 
ATOM   1412 C CB  . ILE B 1 9   ? -28.716 5.914   2.455   1.00 46.08  ? 13  ILE B CB  1 
ATOM   1413 C CG1 . ILE B 1 9   ? -27.950 7.084   1.819   1.00 50.67  ? 13  ILE B CG1 1 
ATOM   1414 C CG2 . ILE B 1 9   ? -29.886 6.401   3.276   1.00 44.37  ? 13  ILE B CG2 1 
ATOM   1415 C CD1 . ILE B 1 9   ? -28.819 7.961   0.935   1.00 46.08  ? 13  ILE B CD1 1 
ATOM   1416 N N   . PRO B 1 10  ? -28.705 3.411   5.018   1.00 54.56  ? 14  PRO B N   1 
ATOM   1417 C CA  . PRO B 1 10  ? -29.378 2.204   5.474   1.00 48.70  ? 14  PRO B CA  1 
ATOM   1418 C C   . PRO B 1 10  ? -30.866 2.186   5.126   1.00 46.23  ? 14  PRO B C   1 
ATOM   1419 O O   . PRO B 1 10  ? -31.513 3.236   5.018   1.00 43.76  ? 14  PRO B O   1 
ATOM   1420 C CB  . PRO B 1 10  ? -29.209 2.228   7.007   1.00 52.63  ? 14  PRO B CB  1 
ATOM   1421 C CG  . PRO B 1 10  ? -27.998 3.117   7.234   1.00 53.72  ? 14  PRO B CG  1 
ATOM   1422 C CD  . PRO B 1 10  ? -28.100 4.154   6.138   1.00 54.31  ? 14  PRO B CD  1 
ATOM   1423 N N   . GLU B 1 11  ? -31.387 0.963   5.048   1.00 43.48  ? 15  GLU B N   1 
ATOM   1424 C CA  . GLU B 1 11  ? -32.811 0.677   4.748   1.00 39.84  ? 15  GLU B CA  1 
ATOM   1425 C C   . GLU B 1 11  ? -33.730 1.480   5.656   1.00 37.69  ? 15  GLU B C   1 
ATOM   1426 O O   . GLU B 1 11  ? -34.729 2.059   5.175   1.00 36.75  ? 15  GLU B O   1 
ATOM   1427 C CB  . GLU B 1 11  ? -33.028 -0.847  4.847   1.00 46.10  ? 15  GLU B CB  1 
ATOM   1428 C CG  . GLU B 1 11  ? -34.503 -1.222  4.822   1.00 47.59  ? 15  GLU B CG  1 
ATOM   1429 C CD  . GLU B 1 11  ? -34.756 -2.726  4.949   1.00 53.11  ? 15  GLU B CD  1 
ATOM   1430 O OE1 . GLU B 1 11  ? -33.771 -3.513  4.932   1.00 53.30  ? 15  GLU B OE1 1 
ATOM   1431 O OE2 . GLU B 1 11  ? -35.920 -3.095  5.058   1.00 58.36  ? 15  GLU B OE2 1 
ATOM   1432 N N   . ALA B 1 12  ? -33.453 1.538   6.962   1.00 39.53  ? 16  ALA B N   1 
ATOM   1433 C CA  . ALA B 1 12  ? -34.325 2.277   7.916   1.00 44.02  ? 16  ALA B CA  1 
ATOM   1434 C C   . ALA B 1 12  ? -34.353 3.803   7.605   1.00 37.93  ? 16  ALA B C   1 
ATOM   1435 O O   . ALA B 1 12  ? -35.434 4.433   7.681   1.00 40.63  ? 16  ALA B O   1 
ATOM   1436 C CB  . ALA B 1 12  ? -33.834 1.987   9.331   1.00 46.14  ? 16  ALA B CB  1 
ATOM   1437 N N   . GLU B 1 13  ? -33.239 4.397   7.180   1.00 40.88  ? 17  GLU B N   1 
ATOM   1438 C CA  . GLU B 1 13  ? -33.217 5.863   6.873   1.00 45.08  ? 17  GLU B CA  1 
ATOM   1439 C C   . GLU B 1 13  ? -34.029 6.120   5.591   1.00 38.72  ? 17  GLU B C   1 
ATOM   1440 O O   . GLU B 1 13  ? -34.813 7.089   5.563   1.00 41.86  ? 17  GLU B O   1 
ATOM   1441 C CB  . GLU B 1 13  ? -31.784 6.355   6.672   1.00 48.63  ? 17  GLU B CB  1 
ATOM   1442 C CG  . GLU B 1 13  ? -30.905 6.219   7.887   1.00 64.13  ? 17  GLU B CG  1 
ATOM   1443 C CD  . GLU B 1 13  ? -29.545 6.900   7.770   1.00 70.84  ? 17  GLU B CD  1 
ATOM   1444 O OE1 . GLU B 1 13  ? -29.430 7.925   7.008   1.00 50.36  ? 17  GLU B OE1 1 
ATOM   1445 O OE2 . GLU B 1 13  ? -28.604 6.394   8.455   1.00 71.88  ? 17  GLU B OE2 1 
ATOM   1446 N N   . ILE B 1 14  ? -33.868 5.251   4.573   1.00 39.60  ? 18  ILE B N   1 
ATOM   1447 C CA  . ILE B 1 14  ? -34.662 5.345   3.311   1.00 37.65  ? 18  ILE B CA  1 
ATOM   1448 C C   . ILE B 1 14  ? -36.137 5.321   3.690   1.00 41.16  ? 18  ILE B C   1 
ATOM   1449 O O   . ILE B 1 14  ? -36.893 6.236   3.290   1.00 38.14  ? 18  ILE B O   1 
ATOM   1450 C CB  . ILE B 1 14  ? -34.306 4.214   2.328   1.00 40.00  ? 18  ILE B CB  1 
ATOM   1451 C CG1 . ILE B 1 14  ? -32.838 4.269   1.912   1.00 45.10  ? 18  ILE B CG1 1 
ATOM   1452 C CG2 . ILE B 1 14  ? -35.241 4.278   1.133   1.00 40.95  ? 18  ILE B CG2 1 
ATOM   1453 C CD1 . ILE B 1 14  ? -32.412 3.167   1.007   1.00 44.93  ? 18  ILE B CD1 1 
ATOM   1454 N N   . LYS B 1 15  ? -36.548 4.296   4.448   1.00 41.34  ? 19  LYS B N   1 
ATOM   1455 C CA  . LYS B 1 15  ? -37.975 4.153   4.849   1.00 44.49  ? 19  LYS B CA  1 
ATOM   1456 C C   . LYS B 1 15  ? -38.498 5.398   5.588   1.00 37.92  ? 19  LYS B C   1 
ATOM   1457 O O   . LYS B 1 15  ? -39.621 5.916   5.261   1.00 34.51  ? 19  LYS B O   1 
ATOM   1458 C CB  . LYS B 1 15  ? -38.091 2.913   5.743   1.00 52.32  ? 19  LYS B CB  1 
ATOM   1459 C CG  . LYS B 1 15  ? -39.474 2.577   6.283   1.00 59.65  ? 19  LYS B CG  1 
ATOM   1460 C CD  . LYS B 1 15  ? -39.408 1.316   7.192   1.00 61.84  ? 19  LYS B CD  1 
ATOM   1461 C CE  . LYS B 1 15  ? -40.650 0.448   7.169   1.00 65.59  ? 19  LYS B CE  1 
ATOM   1462 N NZ  . LYS B 1 15  ? -41.856 1.267   7.408   1.00 66.44  ? 19  LYS B NZ  1 
ATOM   1463 N N   . ALA B 1 16  ? -37.783 5.888   6.603   1.00 39.17  ? 20  ALA B N   1 
ATOM   1464 C CA  . ALA B 1 16  ? -38.224 7.131   7.300   1.00 39.76  ? 20  ALA B CA  1 
ATOM   1465 C C   . ALA B 1 16  ? -38.295 8.314   6.313   1.00 35.29  ? 20  ALA B C   1 
ATOM   1466 O O   . ALA B 1 16  ? -39.278 9.083   6.337   1.00 39.53  ? 20  ALA B O   1 
ATOM   1467 C CB  . ALA B 1 16  ? -37.292 7.432   8.484   1.00 45.73  ? 20  ALA B CB  1 
ATOM   1468 N N   . ARG B 1 17  ? -37.334 8.439   5.401   1.00 39.24  ? 21  ARG B N   1 
ATOM   1469 C CA  . ARG B 1 17  ? -37.357 9.586   4.451   1.00 39.32  ? 21  ARG B CA  1 
ATOM   1470 C C   . ARG B 1 17  ? -38.531 9.444   3.473   1.00 36.83  ? 21  ARG B C   1 
ATOM   1471 O O   . ARG B 1 17  ? -39.245 10.433  3.203   1.00 37.14  ? 21  ARG B O   1 
ATOM   1472 C CB  . ARG B 1 17  ? -36.017 9.727   3.715   1.00 39.72  ? 21  ARG B CB  1 
ATOM   1473 C CG  . ARG B 1 17  ? -35.825 11.069  3.002   1.00 43.06  ? 21  ARG B CG  1 
ATOM   1474 C CD  . ARG B 1 17  ? -35.876 12.355  3.856   1.00 46.09  ? 21  ARG B CD  1 
ATOM   1475 N NE  . ARG B 1 17  ? -35.989 13.498  2.945   1.00 44.15  ? 21  ARG B NE  1 
ATOM   1476 C CZ  . ARG B 1 17  ? -36.754 14.577  3.085   1.00 45.66  ? 21  ARG B CZ  1 
ATOM   1477 N NH1 . ARG B 1 17  ? -37.542 14.752  4.129   1.00 46.18  ? 21  ARG B NH1 1 
ATOM   1478 N NH2 . ARG B 1 17  ? -36.777 15.477  2.112   1.00 44.60  ? 21  ARG B NH2 1 
ATOM   1479 N N   . ILE B 1 18  ? -38.800 8.225   2.992   1.00 39.28  ? 22  ILE B N   1 
ATOM   1480 C CA  . ILE B 1 18  ? -39.940 8.032   2.057   1.00 35.76  ? 22  ILE B CA  1 
ATOM   1481 C C   . ILE B 1 18  ? -41.254 8.366   2.727   1.00 32.94  ? 22  ILE B C   1 
ATOM   1482 O O   . ILE B 1 18  ? -42.129 9.024   2.063   1.00 34.77  ? 22  ILE B O   1 
ATOM   1483 C CB  . ILE B 1 18  ? -39.878 6.640   1.396   1.00 41.96  ? 22  ILE B CB  1 
ATOM   1484 C CG1 . ILE B 1 18  ? -38.677 6.617   0.448   1.00 42.90  ? 22  ILE B CG1 1 
ATOM   1485 C CG2 . ILE B 1 18  ? -41.210 6.365   0.678   1.00 43.44  ? 22  ILE B CG2 1 
ATOM   1486 C CD1 . ILE B 1 18  ? -38.429 5.309   -0.252  1.00 52.57  ? 22  ILE B CD1 1 
ATOM   1487 N N   . ALA B 1 19  ? -41.413 8.047   4.017   1.00 37.09  ? 23  ALA B N   1 
ATOM   1488 C CA  . ALA B 1 19  ? -42.651 8.405   4.764   1.00 43.60  ? 23  ALA B CA  1 
ATOM   1489 C C   . ALA B 1 19  ? -42.832 9.939   4.825   1.00 37.29  ? 23  ALA B C   1 
ATOM   1490 O O   . ALA B 1 19  ? -43.977 10.480  4.657   1.00 37.25  ? 23  ALA B O   1 
ATOM   1491 C CB  . ALA B 1 19  ? -42.620 7.780   6.170   1.00 45.08  ? 23  ALA B CB  1 
ATOM   1492 N N   . GLU B 1 20  ? -41.755 10.685  5.068   1.00 44.22  ? 24  GLU B N   1 
ATOM   1493 C CA  . GLU B 1 20  ? -41.833 12.179  5.066   1.00 41.15  ? 24  GLU B CA  1 
ATOM   1494 C C   . GLU B 1 20  ? -42.163 12.659  3.635   1.00 38.00  ? 24  GLU B C   1 
ATOM   1495 O O   . GLU B 1 20  ? -43.072 13.454  3.442   1.00 40.84  ? 24  GLU B O   1 
ATOM   1496 C CB  . GLU B 1 20  ? -40.506 12.720  5.644   1.00 45.44  ? 24  GLU B CB  1 
ATOM   1497 C CG  . GLU B 1 20  ? -40.363 14.234  5.683   1.00 48.29  ? 24  GLU B CG  1 
ATOM   1498 C CD  . GLU B 1 20  ? -41.511 15.002  6.329   1.00 49.59  ? 24  GLU B CD  1 
ATOM   1499 O OE1 . GLU B 1 20  ? -42.161 14.464  7.224   1.00 51.81  ? 24  GLU B OE1 1 
ATOM   1500 O OE2 . GLU B 1 20  ? -41.794 16.121  5.868   1.00 54.80  ? 24  GLU B OE2 1 
ATOM   1501 N N   . LEU B 1 21  ? -41.452 12.176  2.625   1.00 39.54  ? 25  LEU B N   1 
ATOM   1502 C CA  . LEU B 1 21  ? -41.768 12.595  1.230   1.00 39.42  ? 25  LEU B CA  1 
ATOM   1503 C C   . LEU B 1 21  ? -43.253 12.362  0.984   1.00 40.90  ? 25  LEU B C   1 
ATOM   1504 O O   . LEU B 1 21  ? -43.966 13.247  0.399   1.00 33.58  ? 25  LEU B O   1 
ATOM   1505 C CB  . LEU B 1 21  ? -40.892 11.800  0.269   1.00 36.72  ? 25  LEU B CB  1 
ATOM   1506 C CG  . LEU B 1 21  ? -39.438 12.225  0.157   1.00 40.94  ? 25  LEU B CG  1 
ATOM   1507 C CD1 . LEU B 1 21  ? -38.754 11.368  -0.874  1.00 40.86  ? 25  LEU B CD1 1 
ATOM   1508 C CD2 . LEU B 1 21  ? -39.293 13.713  -0.189  1.00 42.22  ? 25  LEU B CD2 1 
ATOM   1509 N N   . GLY B 1 22  ? -43.756 11.195  1.418   1.00 41.86  ? 26  GLY B N   1 
ATOM   1510 C CA  . GLY B 1 22  ? -45.173 10.897  1.159   1.00 37.63  ? 26  GLY B CA  1 
ATOM   1511 C C   . GLY B 1 22  ? -46.096 11.879  1.863   1.00 41.31  ? 26  GLY B C   1 
ATOM   1512 O O   . GLY B 1 22  ? -47.146 12.309  1.249   1.00 38.15  ? 26  GLY B O   1 
ATOM   1513 N N   . ARG B 1 23  ? -45.805 12.205  3.127   1.00 44.11  ? 27  ARG B N   1 
ATOM   1514 C CA  . ARG B 1 23  ? -46.601 13.276  3.814   1.00 44.61  ? 27  ARG B CA  1 
ATOM   1515 C C   . ARG B 1 23  ? -46.505 14.573  3.008   1.00 38.78  ? 27  ARG B C   1 
ATOM   1516 O O   . ARG B 1 23  ? -47.508 15.200  2.810   1.00 40.08  ? 27  ARG B O   1 
ATOM   1517 C CB  . ARG B 1 23  ? -46.149 13.558  5.258   1.00 48.89  ? 27  ARG B CB  1 
ATOM   1518 C CG  . ARG B 1 23  ? -46.451 12.449  6.269   1.00 54.53  ? 27  ARG B CG  1 
ATOM   1519 C CD  . ARG B 1 23  ? -46.020 12.769  7.723   1.00 55.46  ? 27  ARG B CD  1 
ATOM   1520 N NE  . ARG B 1 23  ? -44.562 12.689  7.949   1.00 52.82  ? 27  ARG B NE  1 
ATOM   1521 C CZ  . ARG B 1 23  ? -43.888 11.591  8.303   1.00 53.69  ? 27  ARG B CZ  1 
ATOM   1522 N NH1 . ARG B 1 23  ? -44.526 10.460  8.507   1.00 56.27  ? 27  ARG B NH1 1 
ATOM   1523 N NH2 . ARG B 1 23  ? -42.572 11.606  8.436   1.00 52.15  ? 27  ARG B NH2 1 
ATOM   1524 N N   . GLN B 1 24  ? -45.329 14.989  2.553   1.00 41.83  ? 28  GLN B N   1 
ATOM   1525 C CA  . GLN B 1 24  ? -45.241 16.280  1.792   1.00 41.78  ? 28  GLN B CA  1 
ATOM   1526 C C   . GLN B 1 24  ? -46.040 16.213  0.494   1.00 47.64  ? 28  GLN B C   1 
ATOM   1527 O O   . GLN B 1 24  ? -46.789 17.216  0.191   1.00 44.29  ? 28  GLN B O   1 
ATOM   1528 C CB  . GLN B 1 24  ? -43.796 16.662  1.480   1.00 42.76  ? 28  GLN B CB  1 
ATOM   1529 C CG  . GLN B 1 24  ? -43.057 17.122  2.718   1.00 45.17  ? 28  GLN B CG  1 
ATOM   1530 C CD  . GLN B 1 24  ? -41.581 17.231  2.450   1.00 50.35  ? 28  GLN B CD  1 
ATOM   1531 O OE1 . GLN B 1 24  ? -41.169 17.455  1.330   1.00 56.17  ? 28  GLN B OE1 1 
ATOM   1532 N NE2 . GLN B 1 24  ? -40.780 17.008  3.481   1.00 54.28  ? 28  GLN B NE2 1 
ATOM   1533 N N   . ILE B 1 25  ? -45.925 15.102  -0.267  1.00 42.30  ? 29  ILE B N   1 
ATOM   1534 C CA  . ILE B 1 25  ? -46.675 14.990  -1.554  1.00 36.68  ? 29  ILE B CA  1 
ATOM   1535 C C   . ILE B 1 25  ? -48.182 15.009  -1.266  1.00 36.71  ? 29  ILE B C   1 
ATOM   1536 O O   . ILE B 1 25  ? -48.966 15.710  -1.990  1.00 40.59  ? 29  ILE B O   1 
ATOM   1537 C CB  . ILE B 1 25  ? -46.211 13.745  -2.355  1.00 40.44  ? 29  ILE B CB  1 
ATOM   1538 C CG1 . ILE B 1 25  ? -44.768 13.925  -2.814  1.00 41.73  ? 29  ILE B CG1 1 
ATOM   1539 C CG2 . ILE B 1 25  ? -47.130 13.517  -3.523  1.00 38.39  ? 29  ILE B CG2 1 
ATOM   1540 C CD1 . ILE B 1 25  ? -44.001 12.656  -2.959  1.00 40.26  ? 29  ILE B CD1 1 
ATOM   1541 N N   . THR B 1 26  ? -48.605 14.308  -0.221  1.00 41.24  ? 30  THR B N   1 
ATOM   1542 C CA  . THR B 1 26  ? -50.024 14.267  0.190   1.00 47.27  ? 30  THR B CA  1 
ATOM   1543 C C   . THR B 1 26  ? -50.507 15.703  0.475   1.00 49.18  ? 30  THR B C   1 
ATOM   1544 O O   . THR B 1 26  ? -51.580 16.100  -0.089  1.00 43.31  ? 30  THR B O   1 
ATOM   1545 C CB  . THR B 1 26  ? -50.228 13.301  1.367   1.00 44.95  ? 30  THR B CB  1 
ATOM   1546 O OG1 . THR B 1 26  ? -49.853 11.981  0.955   1.00 45.89  ? 30  THR B OG1 1 
ATOM   1547 C CG2 . THR B 1 26  ? -51.671 13.311  1.825   1.00 47.32  ? 30  THR B CG2 1 
ATOM   1548 N N   . GLU B 1 27  ? -49.776 16.462  1.313   1.00 50.23  ? 31  GLU B N   1 
ATOM   1549 C CA  . GLU B 1 27  ? -50.187 17.855  1.669   1.00 53.67  ? 31  GLU B CA  1 
ATOM   1550 C C   . GLU B 1 27  ? -50.279 18.653  0.360   1.00 52.84  ? 31  GLU B C   1 
ATOM   1551 O O   . GLU B 1 27  ? -51.278 19.337  0.174   1.00 50.88  ? 31  GLU B O   1 
ATOM   1552 C CB  . GLU B 1 27  ? -49.244 18.520  2.688   1.00 47.38  ? 31  GLU B CB  1 
ATOM   1553 N N   . ARG B 1 28  ? -49.296 18.542  -0.539  1.00 47.96  ? 32  ARG B N   1 
ATOM   1554 C CA  . ARG B 1 28  ? -49.274 19.373  -1.770  1.00 47.65  ? 32  ARG B CA  1 
ATOM   1555 C C   . ARG B 1 28  ? -50.534 19.098  -2.601  1.00 51.15  ? 32  ARG B C   1 
ATOM   1556 O O   . ARG B 1 28  ? -51.074 20.040  -3.124  1.00 56.97  ? 32  ARG B O   1 
ATOM   1557 C CB  . ARG B 1 28  ? -47.965 19.158  -2.530  1.00 51.09  ? 32  ARG B CB  1 
ATOM   1558 C CG  . ARG B 1 28  ? -47.848 19.812  -3.908  1.00 62.62  ? 32  ARG B CG  1 
ATOM   1559 C CD  . ARG B 1 28  ? -48.413 21.209  -4.226  1.00 73.24  ? 32  ARG B CD  1 
ATOM   1560 N NE  . ARG B 1 28  ? -48.356 21.506  -5.697  1.00 87.19  ? 32  ARG B NE  1 
ATOM   1561 C CZ  . ARG B 1 28  ? -49.383 21.602  -6.591  1.00 70.91  ? 32  ARG B CZ  1 
ATOM   1562 N NH1 . ARG B 1 28  ? -50.653 21.458  -6.244  1.00 70.47  ? 32  ARG B NH1 1 
ATOM   1563 N NH2 . ARG B 1 28  ? -49.122 21.836  -7.867  1.00 63.45  ? 32  ARG B NH2 1 
ATOM   1564 N N   . TYR B 1 29  ? -51.022 17.860  -2.712  1.00 48.38  ? 33  TYR B N   1 
ATOM   1565 C CA  . TYR B 1 29  ? -51.926 17.490  -3.823  1.00 46.47  ? 33  TYR B CA  1 
ATOM   1566 C C   . TYR B 1 29  ? -53.311 17.145  -3.300  1.00 48.30  ? 33  TYR B C   1 
ATOM   1567 O O   . TYR B 1 29  ? -54.183 16.995  -4.149  1.00 52.86  ? 33  TYR B O   1 
ATOM   1568 C CB  . TYR B 1 29  ? -51.369 16.339  -4.677  1.00 50.11  ? 33  TYR B CB  1 
ATOM   1569 C CG  . TYR B 1 29  ? -50.177 16.694  -5.530  1.00 42.27  ? 33  TYR B CG  1 
ATOM   1570 C CD1 . TYR B 1 29  ? -50.325 17.340  -6.749  1.00 38.02  ? 33  TYR B CD1 1 
ATOM   1571 C CD2 . TYR B 1 29  ? -48.904 16.398  -5.108  1.00 37.75  ? 33  TYR B CD2 1 
ATOM   1572 C CE1 . TYR B 1 29  ? -49.224 17.689  -7.520  1.00 38.03  ? 33  TYR B CE1 1 
ATOM   1573 C CE2 . TYR B 1 29  ? -47.796 16.743  -5.857  1.00 40.68  ? 33  TYR B CE2 1 
ATOM   1574 C CZ  . TYR B 1 29  ? -47.954 17.392  -7.061  1.00 40.70  ? 33  TYR B CZ  1 
ATOM   1575 O OH  . TYR B 1 29  ? -46.856 17.668  -7.803  1.00 42.12  ? 33  TYR B OH  1 
ATOM   1576 N N   . LYS B 1 30  ? -53.532 17.090  -1.991  1.00 52.42  ? 34  LYS B N   1 
ATOM   1577 C CA  . LYS B 1 30  ? -54.814 16.540  -1.475  1.00 60.23  ? 34  LYS B CA  1 
ATOM   1578 C C   . LYS B 1 30  ? -56.010 17.444  -1.836  1.00 56.62  ? 34  LYS B C   1 
ATOM   1579 O O   . LYS B 1 30  ? -57.113 16.904  -1.918  1.00 55.27  ? 34  LYS B O   1 
ATOM   1580 C CB  . LYS B 1 30  ? -54.747 16.300  0.031   1.00 64.26  ? 34  LYS B CB  1 
ATOM   1581 C CG  . LYS B 1 30  ? -54.723 17.560  0.878   1.00 65.12  ? 34  LYS B CG  1 
ATOM   1582 C CD  . LYS B 1 30  ? -54.662 17.253  2.364   1.00 71.45  ? 34  LYS B CD  1 
ATOM   1583 C CE  . LYS B 1 30  ? -55.000 18.446  3.225   1.00 78.98  ? 34  LYS B CE  1 
ATOM   1584 N NZ  . LYS B 1 30  ? -54.189 19.617  2.826   1.00 81.93  ? 34  LYS B NZ  1 
ATOM   1585 N N   . ASP B 1 31  ? -55.828 18.741  -2.085  1.00 56.97  ? 35  ASP B N   1 
ATOM   1586 C CA  . ASP B 1 31  ? -56.957 19.684  -2.359  1.00 69.38  ? 35  ASP B CA  1 
ATOM   1587 C C   . ASP B 1 31  ? -57.257 19.817  -3.857  1.00 67.42  ? 35  ASP B C   1 
ATOM   1588 O O   . ASP B 1 31  ? -58.192 20.546  -4.210  1.00 65.87  ? 35  ASP B O   1 
ATOM   1589 C CB  . ASP B 1 31  ? -56.650 21.086  -1.817  1.00 72.20  ? 35  ASP B CB  1 
ATOM   1590 C CG  . ASP B 1 31  ? -56.587 21.117  -0.301  1.00 74.38  ? 35  ASP B CG  1 
ATOM   1591 O OD1 . ASP B 1 31  ? -57.294 20.307  0.322   1.00 72.63  ? 35  ASP B OD1 1 
ATOM   1592 O OD2 . ASP B 1 31  ? -55.801 21.921  0.234   1.00 85.71  ? 35  ASP B OD2 1 
ATOM   1593 N N   . SER B 1 32  ? -56.482 19.179  -4.727  1.00 59.54  ? 36  SER B N   1 
ATOM   1594 C CA  . SER B 1 32  ? -56.536 19.448  -6.178  1.00 56.73  ? 36  SER B CA  1 
ATOM   1595 C C   . SER B 1 32  ? -57.897 19.028  -6.728  1.00 58.57  ? 36  SER B C   1 
ATOM   1596 O O   . SER B 1 32  ? -58.429 19.765  -7.554  1.00 58.92  ? 36  SER B O   1 
ATOM   1597 C CB  . SER B 1 32  ? -55.420 18.764  -6.906  1.00 54.58  ? 36  SER B CB  1 
ATOM   1598 O OG  . SER B 1 32  ? -55.512 19.070  -8.286  1.00 50.76  ? 36  SER B OG  1 
ATOM   1599 N N   . GLY B 1 33  ? -58.388 17.850  -6.340  1.00 68.72  ? 37  GLY B N   1 
ATOM   1600 C CA  . GLY B 1 33  ? -59.583 17.206  -6.924  1.00 73.04  ? 37  GLY B CA  1 
ATOM   1601 C C   . GLY B 1 33  ? -59.517 17.063  -8.443  1.00 78.96  ? 37  GLY B C   1 
ATOM   1602 O O   . GLY B 1 33  ? -60.581 17.074  -9.059  1.00 87.01  ? 37  GLY B O   1 
ATOM   1603 N N   . SER B 1 34  ? -58.317 16.989  -9.036  1.00 68.60  ? 38  SER B N   1 
ATOM   1604 C CA  . SER B 1 34  ? -58.055 16.507  -10.417 1.00 63.14  ? 38  SER B CA  1 
ATOM   1605 C C   . SER B 1 34  ? -57.482 15.091  -10.315 1.00 56.03  ? 38  SER B C   1 
ATOM   1606 O O   . SER B 1 34  ? -56.901 14.785  -9.284  1.00 56.07  ? 38  SER B O   1 
ATOM   1607 C CB  . SER B 1 34  ? -57.101 17.416  -11.154 1.00 64.05  ? 38  SER B CB  1 
ATOM   1608 O OG  . SER B 1 34  ? -57.758 18.598  -11.582 1.00 60.67  ? 38  SER B OG  1 
ATOM   1609 N N   . ASP B 1 35  ? -57.586 14.268  -11.349 1.00 51.87  ? 39  ASP B N   1 
ATOM   1610 C CA  . ASP B 1 35  ? -56.855 12.976  -11.367 1.00 50.94  ? 39  ASP B CA  1 
ATOM   1611 C C   . ASP B 1 35  ? -55.352 13.245  -11.186 1.00 51.01  ? 39  ASP B C   1 
ATOM   1612 O O   . ASP B 1 35  ? -54.826 14.314  -11.573 1.00 48.04  ? 39  ASP B O   1 
ATOM   1613 C CB  . ASP B 1 35  ? -57.111 12.193  -12.651 1.00 54.38  ? 39  ASP B CB  1 
ATOM   1614 C CG  . ASP B 1 35  ? -58.549 11.722  -12.775 1.00 61.33  ? 39  ASP B CG  1 
ATOM   1615 O OD1 . ASP B 1 35  ? -59.250 11.737  -11.761 1.00 57.41  ? 39  ASP B OD1 1 
ATOM   1616 O OD2 . ASP B 1 35  ? -58.966 11.392  -13.899 1.00 65.57  ? 39  ASP B OD2 1 
ATOM   1617 N N   . MET B 1 36  ? -54.662 12.269  -10.628 1.00 46.76  ? 40  MET B N   1 
ATOM   1618 C CA  . MET B 1 36  ? -53.214 12.349  -10.332 1.00 45.85  ? 40  MET B CA  1 
ATOM   1619 C C   . MET B 1 36  ? -52.554 11.093  -10.887 1.00 46.34  ? 40  MET B C   1 
ATOM   1620 O O   . MET B 1 36  ? -53.155 10.012  -10.731 1.00 41.25  ? 40  MET B O   1 
ATOM   1621 C CB  . MET B 1 36  ? -53.020 12.437  -8.824  1.00 44.37  ? 40  MET B CB  1 
ATOM   1622 C CG  . MET B 1 36  ? -51.602 12.673  -8.461  1.00 50.89  ? 40  MET B CG  1 
ATOM   1623 S SD  . MET B 1 36  ? -51.373 12.860  -6.707  1.00 53.55  ? 40  MET B SD  1 
ATOM   1624 C CE  . MET B 1 36  ? -49.615 13.196  -6.696  1.00 53.21  ? 40  MET B CE  1 
ATOM   1625 N N   . VAL B 1 37  ? -51.361 11.207  -11.465 1.00 40.49  ? 41  VAL B N   1 
ATOM   1626 C CA  . VAL B 1 37  ? -50.562 10.018  -11.827 1.00 46.85  ? 41  VAL B CA  1 
ATOM   1627 C C   . VAL B 1 37  ? -49.105 10.235  -11.408 1.00 46.64  ? 41  VAL B C   1 
ATOM   1628 O O   . VAL B 1 37  ? -48.568 11.357  -11.610 1.00 42.29  ? 41  VAL B O   1 
ATOM   1629 C CB  . VAL B 1 37  ? -50.778 9.627   -13.309 1.00 49.54  ? 41  VAL B CB  1 
ATOM   1630 C CG1 . VAL B 1 37  ? -51.275 10.774  -14.158 1.00 54.80  ? 41  VAL B CG1 1 
ATOM   1631 C CG2 . VAL B 1 37  ? -49.609 8.913   -13.948 1.00 45.43  ? 41  VAL B CG2 1 
ATOM   1632 N N   . LEU B 1 38  ? -48.512 9.203   -10.792 1.00 35.97  ? 42  LEU B N   1 
ATOM   1633 C CA  . LEU B 1 38  ? -47.061 9.111   -10.561 1.00 33.45  ? 42  LEU B CA  1 
ATOM   1634 C C   . LEU B 1 38  ? -46.515 8.343   -11.736 1.00 40.11  ? 42  LEU B C   1 
ATOM   1635 O O   . LEU B 1 38  ? -47.067 7.223   -12.089 1.00 42.32  ? 42  LEU B O   1 
ATOM   1636 C CB  . LEU B 1 38  ? -46.688 8.403   -9.253  1.00 40.07  ? 42  LEU B CB  1 
ATOM   1637 C CG  . LEU B 1 38  ? -47.367 8.828   -7.959  1.00 49.64  ? 42  LEU B CG  1 
ATOM   1638 C CD1 . LEU B 1 38  ? -46.501 8.454   -6.769  1.00 46.17  ? 42  LEU B CD1 1 
ATOM   1639 C CD2 . LEU B 1 38  ? -47.771 10.281  -7.903  1.00 51.05  ? 42  LEU B CD2 1 
ATOM   1640 N N   . VAL B 1 39  ? -45.509 8.920   -12.340 1.00 35.17  ? 43  VAL B N   1 
ATOM   1641 C CA  . VAL B 1 39  ? -44.852 8.379   -13.537 1.00 37.36  ? 43  VAL B CA  1 
ATOM   1642 C C   . VAL B 1 39  ? -43.424 8.044   -13.164 1.00 38.78  ? 43  VAL B C   1 
ATOM   1643 O O   . VAL B 1 39  ? -42.619 8.969   -13.043 1.00 39.21  ? 43  VAL B O   1 
ATOM   1644 C CB  . VAL B 1 39  ? -44.913 9.398   -14.692 1.00 39.01  ? 43  VAL B CB  1 
ATOM   1645 C CG1 . VAL B 1 39  ? -44.081 8.913   -15.860 1.00 39.54  ? 43  VAL B CG1 1 
ATOM   1646 C CG2 . VAL B 1 39  ? -46.340 9.715   -15.094 1.00 38.62  ? 43  VAL B CG2 1 
ATOM   1647 N N   . GLY B 1 40  ? -43.074 6.755   -13.165 1.00 34.99  ? 44  GLY B N   1 
ATOM   1648 C CA  . GLY B 1 40  ? -41.713 6.359   -12.873 1.00 31.01  ? 44  GLY B CA  1 
ATOM   1649 C C   . GLY B 1 40  ? -40.929 6.220   -14.132 1.00 36.86  ? 44  GLY B C   1 
ATOM   1650 O O   . GLY B 1 40  ? -41.494 5.670   -15.091 1.00 38.65  ? 44  GLY B O   1 
ATOM   1651 N N   . LEU B 1 41  ? -39.629 6.518   -14.062 1.00 33.12  ? 45  LEU B N   1 
ATOM   1652 C CA  . LEU B 1 41  ? -38.703 6.317   -15.193 1.00 36.42  ? 45  LEU B CA  1 
ATOM   1653 C C   . LEU B 1 41  ? -38.012 4.987   -14.961 1.00 41.03  ? 45  LEU B C   1 
ATOM   1654 O O   . LEU B 1 41  ? -37.321 4.888   -13.954 1.00 38.16  ? 45  LEU B O   1 
ATOM   1655 C CB  . LEU B 1 41  ? -37.699 7.487   -15.250 1.00 40.36  ? 45  LEU B CB  1 
ATOM   1656 C CG  . LEU B 1 41  ? -38.369 8.860   -15.350 1.00 45.16  ? 45  LEU B CG  1 
ATOM   1657 C CD1 . LEU B 1 41  ? -37.373 9.998   -15.526 1.00 49.97  ? 45  LEU B CD1 1 
ATOM   1658 C CD2 . LEU B 1 41  ? -39.377 8.885   -16.467 1.00 51.16  ? 45  LEU B CD2 1 
ATOM   1659 N N   . LEU B 1 42  ? -38.144 4.036   -15.886 1.00 38.94  ? 46  LEU B N   1 
ATOM   1660 C CA  . LEU B 1 42  ? -37.592 2.657   -15.780 1.00 41.14  ? 46  LEU B CA  1 
ATOM   1661 C C   . LEU B 1 42  ? -36.167 2.642   -16.314 1.00 44.18  ? 46  LEU B C   1 
ATOM   1662 O O   . LEU B 1 42  ? -35.845 3.454   -17.148 1.00 45.42  ? 46  LEU B O   1 
ATOM   1663 C CB  . LEU B 1 42  ? -38.515 1.690   -16.542 1.00 42.69  ? 46  LEU B CB  1 
ATOM   1664 C CG  . LEU B 1 42  ? -39.815 1.393   -15.819 1.00 45.95  ? 46  LEU B CG  1 
ATOM   1665 C CD1 . LEU B 1 42  ? -40.733 0.512   -16.632 1.00 47.21  ? 46  LEU B CD1 1 
ATOM   1666 C CD2 . LEU B 1 42  ? -39.528 0.755   -14.469 1.00 50.98  ? 46  LEU B CD2 1 
ATOM   1667 N N   . ARG B 1 43  ? -35.315 1.726   -15.836 1.00 41.37  ? 47  ARG B N   1 
ATOM   1668 C CA  . ARG B 1 43  ? -35.692 0.715   -14.860 1.00 46.58  ? 47  ARG B CA  1 
ATOM   1669 C C   . ARG B 1 43  ? -35.509 1.180   -13.419 1.00 45.96  ? 47  ARG B C   1 
ATOM   1670 O O   . ARG B 1 43  ? -36.127 0.599   -12.505 1.00 41.32  ? 47  ARG B O   1 
ATOM   1671 C CB  . ARG B 1 43  ? -34.839 -0.537  -15.048 1.00 47.03  ? 47  ARG B CB  1 
ATOM   1672 C CG  . ARG B 1 43  ? -35.415 -1.447  -16.131 1.00 47.83  ? 47  ARG B CG  1 
ATOM   1673 C CD  . ARG B 1 43  ? -34.598 -2.717  -16.183 1.00 47.20  ? 47  ARG B CD  1 
ATOM   1674 N NE  . ARG B 1 43  ? -33.409 -2.541  -16.998 1.00 43.15  ? 47  ARG B NE  1 
ATOM   1675 C CZ  . ARG B 1 43  ? -32.358 -3.350  -17.011 1.00 48.73  ? 47  ARG B CZ  1 
ATOM   1676 N NH1 . ARG B 1 43  ? -32.261 -4.369  -16.172 1.00 41.41  ? 47  ARG B NH1 1 
ATOM   1677 N NH2 . ARG B 1 43  ? -31.380 -3.117  -17.863 1.00 42.28  ? 47  ARG B NH2 1 
ATOM   1678 N N   . GLY B 1 44  ? -34.633 2.144   -13.203 1.00 39.28  ? 48  GLY B N   1 
ATOM   1679 C CA  . GLY B 1 44  ? -34.070 2.436   -11.877 1.00 39.47  ? 48  GLY B CA  1 
ATOM   1680 C C   . GLY B 1 44  ? -35.090 2.872   -10.848 1.00 39.17  ? 48  GLY B C   1 
ATOM   1681 O O   . GLY B 1 44  ? -34.780 2.720   -9.671  1.00 45.73  ? 48  GLY B O   1 
ATOM   1682 N N   . SER B 1 45  ? -36.274 3.335   -11.245 1.00 31.55  ? 49  SER B N   1 
ATOM   1683 C CA  . SER B 1 45  ? -37.242 3.908   -10.303 1.00 37.63  ? 49  SER B CA  1 
ATOM   1684 C C   . SER B 1 45  ? -38.272 2.884   -9.777  1.00 40.82  ? 49  SER B C   1 
ATOM   1685 O O   . SER B 1 45  ? -39.077 3.287   -8.943  1.00 36.42  ? 49  SER B O   1 
ATOM   1686 C CB  . SER B 1 45  ? -37.857 5.162   -10.929 1.00 43.73  ? 49  SER B CB  1 
ATOM   1687 O OG  . SER B 1 45  ? -39.136 4.868   -11.504 1.00 56.02  ? 49  SER B OG  1 
ATOM   1688 N N   . PHE B 1 46  ? -38.253 1.596   -10.160 1.00 39.75  ? 50  PHE B N   1 
ATOM   1689 C CA  . PHE B 1 46  ? -39.381 0.672   -9.850  1.00 40.11  ? 50  PHE B CA  1 
ATOM   1690 C C   . PHE B 1 46  ? -39.503 0.534   -8.328  1.00 34.39  ? 50  PHE B C   1 
ATOM   1691 O O   . PHE B 1 46  ? -40.617 0.609   -7.817  1.00 36.93  ? 50  PHE B O   1 
ATOM   1692 C CB  . PHE B 1 46  ? -39.240 -0.698  -10.538 1.00 36.61  ? 50  PHE B CB  1 
ATOM   1693 C CG  . PHE B 1 46  ? -38.252 -1.604  -9.865  1.00 35.00  ? 50  PHE B CG  1 
ATOM   1694 C CD1 . PHE B 1 46  ? -36.892 -1.490  -10.121 1.00 34.23  ? 50  PHE B CD1 1 
ATOM   1695 C CD2 . PHE B 1 46  ? -38.681 -2.591  -8.997  1.00 40.83  ? 50  PHE B CD2 1 
ATOM   1696 C CE1 . PHE B 1 46  ? -35.972 -2.326  -9.514  1.00 39.60  ? 50  PHE B CE1 1 
ATOM   1697 C CE2 . PHE B 1 46  ? -37.764 -3.444  -8.401  1.00 40.30  ? 50  PHE B CE2 1 
ATOM   1698 C CZ  . PHE B 1 46  ? -36.411 -3.321  -8.661  1.00 42.03  ? 50  PHE B CZ  1 
ATOM   1699 N N   . MET B 1 47  ? -38.392 0.419   -7.622  1.00 34.22  ? 51  MET B N   1 
ATOM   1700 C CA  . MET B 1 47  ? -38.408 0.171   -6.160  1.00 33.78  ? 51  MET B CA  1 
ATOM   1701 C C   . MET B 1 47  ? -38.812 1.430   -5.387  1.00 39.65  ? 51  MET B C   1 
ATOM   1702 O O   . MET B 1 47  ? -39.729 1.396   -4.535  1.00 37.06  ? 51  MET B O   1 
ATOM   1703 C CB  . MET B 1 47  ? -37.046 -0.297  -5.669  1.00 40.22  ? 51  MET B CB  1 
ATOM   1704 C CG  . MET B 1 47  ? -37.138 -0.864  -4.242  1.00 39.55  ? 51  MET B CG  1 
ATOM   1705 S SD  . MET B 1 47  ? -35.674 -1.660  -3.707  1.00 44.03  ? 51  MET B SD  1 
ATOM   1706 C CE  . MET B 1 47  ? -35.681 -3.128  -4.742  1.00 42.32  ? 51  MET B CE  1 
ATOM   1707 N N   . PHE B 1 48  ? -38.220 2.559   -5.727  1.00 36.58  ? 52  PHE B N   1 
ATOM   1708 C CA  . PHE B 1 48  ? -38.657 3.841   -5.130  1.00 32.85  ? 52  PHE B CA  1 
ATOM   1709 C C   . PHE B 1 48  ? -40.132 4.082   -5.386  1.00 31.87  ? 52  PHE B C   1 
ATOM   1710 O O   . PHE B 1 48  ? -40.884 4.519   -4.489  1.00 33.21  ? 52  PHE B O   1 
ATOM   1711 C CB  . PHE B 1 48  ? -37.789 4.960   -5.702  1.00 38.60  ? 52  PHE B CB  1 
ATOM   1712 C CG  . PHE B 1 48  ? -38.094 6.322   -5.162  1.00 39.25  ? 52  PHE B CG  1 
ATOM   1713 C CD1 . PHE B 1 48  ? -38.265 6.520   -3.800  1.00 39.19  ? 52  PHE B CD1 1 
ATOM   1714 C CD2 . PHE B 1 48  ? -38.161 7.415   -6.027  1.00 38.30  ? 52  PHE B CD2 1 
ATOM   1715 C CE1 . PHE B 1 48  ? -38.539 7.792   -3.309  1.00 41.99  ? 52  PHE B CE1 1 
ATOM   1716 C CE2 . PHE B 1 48  ? -38.386 8.684   -5.521  1.00 38.88  ? 52  PHE B CE2 1 
ATOM   1717 C CZ  . PHE B 1 48  ? -38.588 8.865   -4.170  1.00 38.30  ? 52  PHE B CZ  1 
ATOM   1718 N N   . MET B 1 49  ? -40.607 3.832   -6.603  1.00 35.15  ? 53  MET B N   1 
ATOM   1719 C CA  . MET B 1 49  ? -42.056 4.026   -6.873  1.00 35.14  ? 53  MET B CA  1 
ATOM   1720 C C   . MET B 1 49  ? -42.925 3.117   -5.983  1.00 32.41  ? 53  MET B C   1 
ATOM   1721 O O   . MET B 1 49  ? -43.932 3.618   -5.435  1.00 33.52  ? 53  MET B O   1 
ATOM   1722 C CB  . MET B 1 49  ? -42.369 3.769   -8.348  1.00 40.17  ? 53  MET B CB  1 
ATOM   1723 C CG  . MET B 1 49  ? -43.827 3.778   -8.640  1.00 36.84  ? 53  MET B CG  1 
ATOM   1724 S SD  . MET B 1 49  ? -44.502 5.462   -8.629  1.00 41.31  ? 53  MET B SD  1 
ATOM   1725 C CE  . MET B 1 49  ? -44.000 5.963   -10.279 1.00 38.74  ? 53  MET B CE  1 
ATOM   1726 N N   . ALA B 1 50  ? -42.592 1.825   -5.857  1.00 33.07  ? 54  ALA B N   1 
ATOM   1727 C CA  . ALA B 1 50  ? -43.389 0.867   -5.029  1.00 32.81  ? 54  ALA B CA  1 
ATOM   1728 C C   . ALA B 1 50  ? -43.519 1.419   -3.609  1.00 32.58  ? 54  ALA B C   1 
ATOM   1729 O O   . ALA B 1 50  ? -44.646 1.485   -3.073  1.00 35.30  ? 54  ALA B O   1 
ATOM   1730 C CB  . ALA B 1 50  ? -42.690 -0.483  -5.001  1.00 33.47  ? 54  ALA B CB  1 
ATOM   1731 N N   . ASP B 1 51  ? -42.399 1.891   -3.035  1.00 38.18  ? 55  ASP B N   1 
ATOM   1732 C CA  . ASP B 1 51  ? -42.392 2.388   -1.625  1.00 38.19  ? 55  ASP B CA  1 
ATOM   1733 C C   . ASP B 1 51  ? -43.060 3.750   -1.560  1.00 36.55  ? 55  ASP B C   1 
ATOM   1734 O O   . ASP B 1 51  ? -43.869 3.955   -0.664  1.00 37.55  ? 55  ASP B O   1 
ATOM   1735 C CB  . ASP B 1 51  ? -40.993 2.414   -1.011  1.00 37.80  ? 55  ASP B CB  1 
ATOM   1736 C CG  . ASP B 1 51  ? -40.482 1.021   -0.783  1.00 36.88  ? 55  ASP B CG  1 
ATOM   1737 O OD1 . ASP B 1 51  ? -41.288 0.035   -1.040  1.00 41.77  ? 55  ASP B OD1 1 
ATOM   1738 O OD2 . ASP B 1 51  ? -39.281 0.897   -0.558  1.00 36.42  ? 55  ASP B OD2 1 
ATOM   1739 N N   . LEU B 1 52  ? -42.795 4.640   -2.510  1.00 39.65  ? 56  LEU B N   1 
ATOM   1740 C CA  . LEU B 1 52  ? -43.348 6.025   -2.412  1.00 34.27  ? 56  LEU B CA  1 
ATOM   1741 C C   . LEU B 1 52  ? -44.855 6.019   -2.622  1.00 33.13  ? 56  LEU B C   1 
ATOM   1742 O O   . LEU B 1 52  ? -45.565 6.695   -1.871  1.00 32.65  ? 56  LEU B O   1 
ATOM   1743 C CB  . LEU B 1 52  ? -42.660 6.933   -3.442  1.00 37.82  ? 56  LEU B CB  1 
ATOM   1744 C CG  . LEU B 1 52  ? -43.160 8.376   -3.421  1.00 37.54  ? 56  LEU B CG  1 
ATOM   1745 C CD1 . LEU B 1 52  ? -42.807 9.044   -2.089  1.00 38.77  ? 56  LEU B CD1 1 
ATOM   1746 C CD2 . LEU B 1 52  ? -42.579 9.125   -4.608  1.00 37.47  ? 56  LEU B CD2 1 
ATOM   1747 N N   . CYS B 1 53  ? -45.365 5.268   -3.610  1.00 35.52  ? 57  CYS B N   1 
ATOM   1748 C CA  . CYS B 1 53  ? -46.803 5.379   -3.971  1.00 31.96  ? 57  CYS B CA  1 
ATOM   1749 C C   . CYS B 1 53  ? -47.608 4.881   -2.779  1.00 31.64  ? 57  CYS B C   1 
ATOM   1750 O O   . CYS B 1 53  ? -48.763 5.380   -2.562  1.00 36.09  ? 57  CYS B O   1 
ATOM   1751 C CB  . CYS B 1 53  ? -47.116 4.651   -5.279  1.00 38.92  ? 57  CYS B CB  1 
ATOM   1752 S SG  . CYS B 1 53  ? -47.207 2.831   -5.121  1.00 40.32  ? 57  CYS B SG  1 
ATOM   1753 N N   . ARG B 1 54  ? -47.053 3.975   -1.969  1.00 36.47  ? 58  ARG B N   1 
ATOM   1754 C CA  . ARG B 1 54  ? -47.791 3.463   -0.780  1.00 40.30  ? 58  ARG B CA  1 
ATOM   1755 C C   . ARG B 1 54  ? -47.834 4.530   0.330   1.00 43.78  ? 58  ARG B C   1 
ATOM   1756 O O   . ARG B 1 54  ? -48.687 4.397   1.183   1.00 39.35  ? 58  ARG B O   1 
ATOM   1757 C CB  . ARG B 1 54  ? -47.183 2.172   -0.214  1.00 39.59  ? 58  ARG B CB  1 
ATOM   1758 C CG  . ARG B 1 54  ? -47.516 0.946   -1.046  1.00 41.40  ? 58  ARG B CG  1 
ATOM   1759 C CD  . ARG B 1 54  ? -46.869 -0.304  -0.541  1.00 36.07  ? 58  ARG B CD  1 
ATOM   1760 N NE  . ARG B 1 54  ? -45.521 -0.454  -1.017  1.00 33.58  ? 58  ARG B NE  1 
ATOM   1761 C CZ  . ARG B 1 54  ? -44.806 -1.556  -0.947  1.00 35.97  ? 58  ARG B CZ  1 
ATOM   1762 N NH1 . ARG B 1 54  ? -45.331 -2.664  -0.449  1.00 40.18  ? 58  ARG B NH1 1 
ATOM   1763 N NH2 . ARG B 1 54  ? -43.592 -1.590  -1.461  1.00 36.76  ? 58  ARG B NH2 1 
ATOM   1764 N N   . GLU B 1 55  ? -46.966 5.541   0.337   1.00 41.44  ? 59  GLU B N   1 
ATOM   1765 C CA  . GLU B 1 55  ? -47.036 6.645   1.348   1.00 41.28  ? 59  GLU B CA  1 
ATOM   1766 C C   . GLU B 1 55  ? -47.842 7.853   0.850   1.00 43.40  ? 59  GLU B C   1 
ATOM   1767 O O   . GLU B 1 55  ? -47.942 8.830   1.625   1.00 49.57  ? 59  GLU B O   1 
ATOM   1768 C CB  . GLU B 1 55  ? -45.616 7.042   1.761   1.00 42.61  ? 59  GLU B CB  1 
ATOM   1769 C CG  . GLU B 1 55  ? -44.817 5.899   2.354   1.00 45.37  ? 59  GLU B CG  1 
ATOM   1770 C CD  . GLU B 1 55  ? -45.389 5.382   3.666   1.00 48.58  ? 59  GLU B CD  1 
ATOM   1771 O OE1 . GLU B 1 55  ? -45.821 6.207   4.461   1.00 43.68  ? 59  GLU B OE1 1 
ATOM   1772 O OE2 . GLU B 1 55  ? -45.452 4.162   3.848   1.00 55.37  ? 59  GLU B OE2 1 
ATOM   1773 N N   . VAL B 1 56  ? -48.319 7.856   -0.400  1.00 40.81  ? 60  VAL B N   1 
ATOM   1774 C CA  . VAL B 1 56  ? -49.081 8.992   -0.978  1.00 39.96  ? 60  VAL B CA  1 
ATOM   1775 C C   . VAL B 1 56  ? -50.572 8.732   -0.731  1.00 50.37  ? 60  VAL B C   1 
ATOM   1776 O O   . VAL B 1 56  ? -51.094 7.825   -1.336  1.00 49.45  ? 60  VAL B O   1 
ATOM   1777 C CB  . VAL B 1 56  ? -48.741 9.230   -2.466  1.00 39.03  ? 60  VAL B CB  1 
ATOM   1778 C CG1 . VAL B 1 56  ? -49.666 10.274  -3.103  1.00 40.25  ? 60  VAL B CG1 1 
ATOM   1779 C CG2 . VAL B 1 56  ? -47.272 9.608   -2.643  1.00 40.67  ? 60  VAL B CG2 1 
ATOM   1780 N N   . GLN B 1 57  ? -51.207 9.493   0.170   1.00 44.22  ? 61  GLN B N   1 
ATOM   1781 C CA  . GLN B 1 57  ? -52.585 9.251   0.664   1.00 49.45  ? 61  GLN B CA  1 
ATOM   1782 C C   . GLN B 1 57  ? -53.543 10.086  -0.180  1.00 47.88  ? 61  GLN B C   1 
ATOM   1783 O O   . GLN B 1 57  ? -54.372 10.808  0.384   1.00 56.55  ? 61  GLN B O   1 
ATOM   1784 C CB  . GLN B 1 57  ? -52.693 9.608   2.150   1.00 51.38  ? 61  GLN B CB  1 
ATOM   1785 C CG  . GLN B 1 57  ? -51.817 8.753   3.029   1.00 53.89  ? 61  GLN B CG  1 
ATOM   1786 C CD  . GLN B 1 57  ? -52.286 7.325   2.991   1.00 69.66  ? 61  GLN B CD  1 
ATOM   1787 O OE1 . GLN B 1 57  ? -53.438 7.018   2.672   1.00 73.92  ? 61  GLN B OE1 1 
ATOM   1788 N NE2 . GLN B 1 57  ? -51.375 6.426   3.303   1.00 75.70  ? 61  GLN B NE2 1 
ATOM   1789 N N   . VAL B 1 58  ? -53.363 10.035  -1.492  1.00 48.13  ? 62  VAL B N   1 
ATOM   1790 C CA  . VAL B 1 58  ? -54.233 10.676  -2.517  1.00 49.08  ? 62  VAL B CA  1 
ATOM   1791 C C   . VAL B 1 58  ? -54.489 9.585   -3.567  1.00 44.02  ? 62  VAL B C   1 
ATOM   1792 O O   . VAL B 1 58  ? -53.521 8.957   -3.970  1.00 49.98  ? 62  VAL B O   1 
ATOM   1793 C CB  . VAL B 1 58  ? -53.542 11.918  -3.139  1.00 50.02  ? 62  VAL B CB  1 
ATOM   1794 C CG1 . VAL B 1 58  ? -54.438 12.645  -4.132  1.00 54.65  ? 62  VAL B CG1 1 
ATOM   1795 C CG2 . VAL B 1 58  ? -53.006 12.912  -2.107  1.00 54.29  ? 62  VAL B CG2 1 
ATOM   1796 N N   . SER B 1 59  ? -55.713 9.428   -4.061  1.00 54.42  ? 63  SER B N   1 
ATOM   1797 C CA  . SER B 1 59  ? -56.026 8.515   -5.189  1.00 56.09  ? 63  SER B CA  1 
ATOM   1798 C C   . SER B 1 59  ? -55.189 8.913   -6.388  1.00 56.77  ? 63  SER B C   1 
ATOM   1799 O O   . SER B 1 59  ? -55.336 10.026  -6.862  1.00 48.47  ? 63  SER B O   1 
ATOM   1800 C CB  . SER B 1 59  ? -57.459 8.517   -5.588  1.00 55.65  ? 63  SER B CB  1 
ATOM   1801 O OG  . SER B 1 59  ? -58.215 8.208   -4.453  1.00 62.09  ? 63  SER B OG  1 
ATOM   1802 N N   . HIS B 1 60  ? -54.416 7.978   -6.911  1.00 43.06  ? 64  HIS B N   1 
ATOM   1803 C CA  . HIS B 1 60  ? -53.655 8.239   -8.143  1.00 43.47  ? 64  HIS B CA  1 
ATOM   1804 C C   . HIS B 1 60  ? -53.555 6.965   -8.961  1.00 41.78  ? 64  HIS B C   1 
ATOM   1805 O O   . HIS B 1 60  ? -53.802 5.890   -8.411  1.00 44.99  ? 64  HIS B O   1 
ATOM   1806 C CB  . HIS B 1 60  ? -52.272 8.766   -7.754  1.00 40.68  ? 64  HIS B CB  1 
ATOM   1807 C CG  . HIS B 1 60  ? -51.463 7.877   -6.855  1.00 33.66  ? 64  HIS B CG  1 
ATOM   1808 N ND1 . HIS B 1 60  ? -51.638 7.849   -5.505  1.00 38.38  ? 64  HIS B ND1 1 
ATOM   1809 C CD2 . HIS B 1 60  ? -50.387 7.085   -7.096  1.00 37.44  ? 64  HIS B CD2 1 
ATOM   1810 C CE1 . HIS B 1 60  ? -50.713 7.082   -4.950  1.00 34.35  ? 64  HIS B CE1 1 
ATOM   1811 N NE2 . HIS B 1 60  ? -49.953 6.565   -5.907  1.00 32.98  ? 64  HIS B NE2 1 
ATOM   1812 N N   . GLU B 1 61  ? -53.107 7.130   -10.191 1.00 42.64  ? 65  GLU B N   1 
ATOM   1813 C CA  . GLU B 1 61  ? -52.667 6.075   -11.125 1.00 48.53  ? 65  GLU B CA  1 
ATOM   1814 C C   . GLU B 1 61  ? -51.139 6.016   -11.035 1.00 40.64  ? 65  GLU B C   1 
ATOM   1815 O O   . GLU B 1 61  ? -50.485 7.034   -10.714 1.00 41.42  ? 65  GLU B O   1 
ATOM   1816 C CB  . GLU B 1 61  ? -53.214 6.412   -12.523 1.00 56.72  ? 65  GLU B CB  1 
ATOM   1817 C CG  . GLU B 1 61  ? -54.684 6.872   -12.507 1.00 74.98  ? 65  GLU B CG  1 
ATOM   1818 C CD  . GLU B 1 61  ? -55.114 8.199   -13.168 1.00 95.22  ? 65  GLU B CD  1 
ATOM   1819 O OE1 . GLU B 1 61  ? -55.091 8.286   -14.463 1.00 78.12  ? 65  GLU B OE1 1 
ATOM   1820 O OE2 . GLU B 1 61  ? -55.533 9.156   -12.391 1.00 71.45  ? 65  GLU B OE2 1 
ATOM   1821 N N   . VAL B 1 62  ? -50.582 4.859   -11.328 1.00 39.24  ? 66  VAL B N   1 
ATOM   1822 C CA  . VAL B 1 62  ? -49.134 4.640   -11.443 1.00 37.20  ? 66  VAL B CA  1 
ATOM   1823 C C   . VAL B 1 62  ? -48.864 4.221   -12.883 1.00 40.12  ? 66  VAL B C   1 
ATOM   1824 O O   . VAL B 1 62  ? -49.572 3.338   -13.405 1.00 41.45  ? 66  VAL B O   1 
ATOM   1825 C CB  . VAL B 1 62  ? -48.679 3.620   -10.406 1.00 38.31  ? 66  VAL B CB  1 
ATOM   1826 C CG1 . VAL B 1 62  ? -47.225 3.255   -10.543 1.00 37.50  ? 66  VAL B CG1 1 
ATOM   1827 C CG2 . VAL B 1 62  ? -49.006 4.126   -9.018  1.00 42.60  ? 66  VAL B CG2 1 
ATOM   1828 N N   . ASP B 1 63  ? -47.906 4.879   -13.521 1.00 35.09  ? 67  ASP B N   1 
ATOM   1829 C CA  . ASP B 1 63  ? -47.524 4.634   -14.925 1.00 33.40  ? 67  ASP B CA  1 
ATOM   1830 C C   . ASP B 1 63  ? -46.020 4.690   -14.973 1.00 40.11  ? 67  ASP B C   1 
ATOM   1831 O O   . ASP B 1 63  ? -45.401 5.048   -13.973 1.00 37.09  ? 67  ASP B O   1 
ATOM   1832 C CB  . ASP B 1 63  ? -48.249 5.601   -15.853 1.00 40.87  ? 67  ASP B CB  1 
ATOM   1833 C CG  . ASP B 1 63  ? -48.501 5.091   -17.267 1.00 43.03  ? 67  ASP B CG  1 
ATOM   1834 O OD1 . ASP B 1 63  ? -47.829 4.111   -17.675 1.00 45.97  ? 67  ASP B OD1 1 
ATOM   1835 O OD2 . ASP B 1 63  ? -49.350 5.705   -17.954 1.00 45.14  ? 67  ASP B OD2 1 
ATOM   1836 N N   . PHE B 1 64  ? -45.457 4.218   -16.064 1.00 38.55  ? 68  PHE B N   1 
ATOM   1837 C CA  . PHE B 1 64  ? -44.010 4.148   -16.245 1.00 38.06  ? 68  PHE B CA  1 
ATOM   1838 C C   . PHE B 1 64  ? -43.654 4.605   -17.659 1.00 44.49  ? 68  PHE B C   1 
ATOM   1839 O O   . PHE B 1 64  ? -44.419 4.429   -18.652 1.00 41.86  ? 68  PHE B O   1 
ATOM   1840 C CB  . PHE B 1 64  ? -43.532 2.720   -15.996 1.00 42.79  ? 68  PHE B CB  1 
ATOM   1841 C CG  . PHE B 1 64  ? -43.641 2.289   -14.562 1.00 41.21  ? 68  PHE B CG  1 
ATOM   1842 C CD1 . PHE B 1 64  ? -42.660 2.645   -13.643 1.00 41.70  ? 68  PHE B CD1 1 
ATOM   1843 C CD2 . PHE B 1 64  ? -44.717 1.532   -14.131 1.00 44.28  ? 68  PHE B CD2 1 
ATOM   1844 C CE1 . PHE B 1 64  ? -42.750 2.245   -12.316 1.00 45.02  ? 68  PHE B CE1 1 
ATOM   1845 C CE2 . PHE B 1 64  ? -44.828 1.184   -12.790 1.00 44.47  ? 68  PHE B CE2 1 
ATOM   1846 C CZ  . PHE B 1 64  ? -43.841 1.524   -11.889 1.00 45.88  ? 68  PHE B CZ  1 
ATOM   1847 N N   . MET B 1 65  ? -42.431 5.076   -17.793 1.00 41.05  ? 69  MET B N   1 
ATOM   1848 C CA  . MET B 1 65  ? -41.922 5.437   -19.113 1.00 45.98  ? 69  MET B CA  1 
ATOM   1849 C C   . MET B 1 65  ? -40.459 5.040   -19.100 1.00 43.85  ? 69  MET B C   1 
ATOM   1850 O O   . MET B 1 65  ? -39.925 4.958   -18.005 1.00 36.53  ? 69  MET B O   1 
ATOM   1851 C CB  . MET B 1 65  ? -42.270 6.919   -19.188 1.00 53.65  ? 69  MET B CB  1 
ATOM   1852 C CG  . MET B 1 65  ? -41.288 7.850   -19.704 1.00 66.34  ? 69  MET B CG  1 
ATOM   1853 S SD  . MET B 1 65  ? -42.285 9.395   -19.812 1.00 68.93  ? 69  MET B SD  1 
ATOM   1854 C CE  . MET B 1 65  ? -41.854 9.764   -21.511 1.00 55.54  ? 69  MET B CE  1 
ATOM   1855 N N   . THR B 1 66  ? -39.909 4.605   -20.232 1.00 36.09  ? 70  THR B N   1 
ATOM   1856 C CA  . THR B 1 66  ? -38.477 4.289   -20.394 1.00 40.19  ? 70  THR B CA  1 
ATOM   1857 C C   . THR B 1 66  ? -37.912 5.269   -21.412 1.00 50.42  ? 70  THR B C   1 
ATOM   1858 O O   . THR B 1 66  ? -38.405 5.281   -22.563 1.00 46.61  ? 70  THR B O   1 
ATOM   1859 C CB  . THR B 1 66  ? -38.246 2.835   -20.819 1.00 44.14  ? 70  THR B CB  1 
ATOM   1860 O OG1 . THR B 1 66  ? -39.024 1.984   -19.997 1.00 45.23  ? 70  THR B OG1 1 
ATOM   1861 C CG2 . THR B 1 66  ? -36.795 2.419   -20.760 1.00 45.11  ? 70  THR B CG2 1 
ATOM   1862 N N   . ALA B 1 67  ? -36.965 6.094   -20.987 1.00 50.16  ? 71  ALA B N   1 
ATOM   1863 C CA  . ALA B 1 67  ? -36.285 7.105   -21.818 1.00 49.84  ? 71  ALA B CA  1 
ATOM   1864 C C   . ALA B 1 67  ? -34.842 6.654   -22.005 1.00 54.73  ? 71  ALA B C   1 
ATOM   1865 O O   . ALA B 1 67  ? -34.415 5.878   -21.187 1.00 56.37  ? 71  ALA B O   1 
ATOM   1866 C CB  . ALA B 1 67  ? -36.409 8.442   -21.163 1.00 52.12  ? 71  ALA B CB  1 
ATOM   1867 N N   . SER B 1 68  ? -34.155 7.016   -23.094 1.00 57.06  ? 72  SER B N   1 
ATOM   1868 C CA  . SER B 1 68  ? -32.740 6.600   -23.326 1.00 61.75  ? 72  SER B CA  1 
ATOM   1869 C C   . SER B 1 68  ? -31.782 7.435   -22.459 1.00 66.21  ? 72  SER B C   1 
ATOM   1870 O O   . SER B 1 68  ? -32.075 8.640   -22.282 1.00 69.91  ? 72  SER B O   1 
ATOM   1871 C CB  . SER B 1 68  ? -32.369 6.692   -24.776 1.00 54.95  ? 72  SER B CB  1 
ATOM   1872 O OG  . SER B 1 68  ? -32.756 7.943   -25.322 1.00 54.60  ? 72  SER B OG  1 
ATOM   1873 N N   . THR B 1 77  ? -24.560 14.276  -25.748 1.00 85.00  ? 81  THR B N   1 
ATOM   1874 C CA  . THR B 1 77  ? -24.166 13.897  -27.135 1.00 93.36  ? 81  THR B CA  1 
ATOM   1875 C C   . THR B 1 77  ? -25.175 12.887  -27.748 1.00 89.67  ? 81  THR B C   1 
ATOM   1876 O O   . THR B 1 77  ? -24.822 12.290  -28.785 1.00 88.73  ? 81  THR B O   1 
ATOM   1877 C CB  . THR B 1 77  ? -22.693 13.427  -27.174 1.00 94.74  ? 81  THR B CB  1 
ATOM   1878 O OG1 . THR B 1 77  ? -22.439 12.467  -26.142 1.00 87.48  ? 81  THR B OG1 1 
ATOM   1879 C CG2 . THR B 1 77  ? -21.684 14.555  -27.043 1.00 87.12  ? 81  THR B CG2 1 
ATOM   1880 N N   . ARG B 1 78  ? -26.387 12.699  -27.189 1.00 79.34  ? 82  ARG B N   1 
ATOM   1881 C CA  . ARG B 1 78  ? -27.449 11.826  -27.781 1.00 66.03  ? 82  ARG B CA  1 
ATOM   1882 C C   . ARG B 1 78  ? -28.838 12.388  -27.464 1.00 64.26  ? 82  ARG B C   1 
ATOM   1883 O O   . ARG B 1 78  ? -29.024 12.921  -26.353 1.00 64.48  ? 82  ARG B O   1 
ATOM   1884 C CB  . ARG B 1 78  ? -27.353 10.395  -27.252 1.00 65.01  ? 82  ARG B CB  1 
ATOM   1885 C CG  . ARG B 1 78  ? -26.140 9.628   -27.759 1.00 78.34  ? 82  ARG B CG  1 
ATOM   1886 C CD  . ARG B 1 78  ? -26.340 9.059   -29.148 1.00 79.55  ? 82  ARG B CD  1 
ATOM   1887 N NE  . ARG B 1 78  ? -26.300 7.600   -29.145 1.00 88.81  ? 82  ARG B NE  1 
ATOM   1888 C CZ  . ARG B 1 78  ? -27.040 6.791   -29.911 1.00 84.41  ? 82  ARG B CZ  1 
ATOM   1889 N NH1 . ARG B 1 78  ? -27.931 7.271   -30.764 1.00 79.65  ? 82  ARG B NH1 1 
ATOM   1890 N NH2 . ARG B 1 78  ? -26.889 5.482   -29.811 1.00 84.03  ? 82  ARG B NH2 1 
ATOM   1891 N N   . ASP B 1 79  ? -29.787 12.277  -28.400 1.00 51.41  ? 83  ASP B N   1 
ATOM   1892 C CA  . ASP B 1 79  ? -31.191 12.707  -28.186 1.00 51.34  ? 83  ASP B CA  1 
ATOM   1893 C C   . ASP B 1 79  ? -31.781 11.888  -27.028 1.00 50.20  ? 83  ASP B C   1 
ATOM   1894 O O   . ASP B 1 79  ? -31.492 10.713  -26.961 1.00 48.62  ? 83  ASP B O   1 
ATOM   1895 C CB  . ASP B 1 79  ? -32.046 12.511  -29.454 1.00 57.20  ? 83  ASP B CB  1 
ATOM   1896 C CG  . ASP B 1 79  ? -31.661 13.347  -30.688 1.00 51.95  ? 83  ASP B CG  1 
ATOM   1897 O OD1 . ASP B 1 79  ? -30.681 14.106  -30.632 1.00 48.65  ? 83  ASP B OD1 1 
ATOM   1898 O OD2 . ASP B 1 79  ? -32.335 13.195  -31.713 1.00 56.69  ? 83  ASP B OD2 1 
ATOM   1899 N N   . VAL B 1 80  ? -32.666 12.449  -26.221 1.00 42.69  ? 84  VAL B N   1 
ATOM   1900 C CA  . VAL B 1 80  ? -33.561 11.629  -25.365 1.00 45.57  ? 84  VAL B CA  1 
ATOM   1901 C C   . VAL B 1 80  ? -34.727 11.083  -26.200 1.00 47.56  ? 84  VAL B C   1 
ATOM   1902 O O   . VAL B 1 80  ? -35.576 11.853  -26.570 1.00 48.77  ? 84  VAL B O   1 
ATOM   1903 C CB  . VAL B 1 80  ? -34.060 12.407  -24.139 1.00 48.84  ? 84  VAL B CB  1 
ATOM   1904 C CG1 . VAL B 1 80  ? -35.068 11.599  -23.337 1.00 49.65  ? 84  VAL B CG1 1 
ATOM   1905 C CG2 . VAL B 1 80  ? -32.895 12.830  -23.248 1.00 51.47  ? 84  VAL B CG2 1 
ATOM   1906 N N   . LYS B 1 81  ? -34.831 9.761   -26.306 1.00 45.21  ? 85  LYS B N   1 
ATOM   1907 C CA  . LYS B 1 81  ? -35.845 9.032   -27.104 1.00 50.92  ? 85  LYS B CA  1 
ATOM   1908 C C   . LYS B 1 81  ? -36.752 8.235   -26.156 1.00 50.82  ? 85  LYS B C   1 
ATOM   1909 O O   . LYS B 1 81  ? -36.243 7.760   -25.137 1.00 51.04  ? 85  LYS B O   1 
ATOM   1910 C CB  . LYS B 1 81  ? -35.117 8.099   -28.070 1.00 49.65  ? 85  LYS B CB  1 
ATOM   1911 C CG  . LYS B 1 81  ? -34.260 8.796   -29.126 1.00 56.75  ? 85  LYS B CG  1 
ATOM   1912 C CD  . LYS B 1 81  ? -33.415 7.808   -29.919 1.00 62.55  ? 85  LYS B CD  1 
ATOM   1913 C CE  . LYS B 1 81  ? -32.298 8.480   -30.695 1.00 64.84  ? 85  LYS B CE  1 
ATOM   1914 N NZ  . LYS B 1 81  ? -31.151 8.846   -29.825 1.00 66.18  ? 85  LYS B NZ  1 
ATOM   1915 N N   . ILE B 1 82  ? -38.033 8.117   -26.496 1.00 45.32  ? 86  ILE B N   1 
ATOM   1916 C CA  . ILE B 1 82  ? -39.057 7.339   -25.756 1.00 47.85  ? 86  ILE B CA  1 
ATOM   1917 C C   . ILE B 1 82  ? -38.934 5.877   -26.188 1.00 47.44  ? 86  ILE B C   1 
ATOM   1918 O O   . ILE B 1 82  ? -39.327 5.574   -27.314 1.00 39.61  ? 86  ILE B O   1 
ATOM   1919 C CB  . ILE B 1 82  ? -40.461 7.899   -26.040 1.00 50.55  ? 86  ILE B CB  1 
ATOM   1920 C CG1 . ILE B 1 82  ? -40.551 9.405   -25.788 1.00 60.47  ? 86  ILE B CG1 1 
ATOM   1921 C CG2 . ILE B 1 82  ? -41.511 7.155   -25.230 1.00 54.38  ? 86  ILE B CG2 1 
ATOM   1922 C CD1 . ILE B 1 82  ? -39.914 9.809   -24.506 1.00 67.50  ? 86  ILE B CD1 1 
ATOM   1923 N N   . LEU B 1 83  ? -38.321 5.012   -25.388 1.00 44.20  ? 87  LEU B N   1 
ATOM   1924 C CA  . LEU B 1 83  ? -38.279 3.560   -25.708 1.00 44.82  ? 87  LEU B CA  1 
ATOM   1925 C C   . LEU B 1 83  ? -39.597 2.911   -25.315 1.00 39.56  ? 87  LEU B C   1 
ATOM   1926 O O   . LEU B 1 83  ? -39.966 1.938   -25.921 1.00 47.27  ? 87  LEU B O   1 
ATOM   1927 C CB  . LEU B 1 83  ? -37.094 2.894   -25.013 1.00 51.32  ? 87  LEU B CB  1 
ATOM   1928 C CG  . LEU B 1 83  ? -35.752 3.553   -25.284 1.00 53.68  ? 87  LEU B CG  1 
ATOM   1929 C CD1 . LEU B 1 83  ? -34.687 2.923   -24.402 1.00 56.68  ? 87  LEU B CD1 1 
ATOM   1930 C CD2 . LEU B 1 83  ? -35.373 3.418   -26.762 1.00 58.50  ? 87  LEU B CD2 1 
ATOM   1931 N N   . LYS B 1 84  ? -40.275 3.424   -24.300 1.00 41.03  ? 88  LYS B N   1 
ATOM   1932 C CA  . LYS B 1 84  ? -41.625 2.972   -23.898 1.00 40.41  ? 88  LYS B CA  1 
ATOM   1933 C C   . LYS B 1 84  ? -42.341 4.202   -23.345 1.00 45.80  ? 88  LYS B C   1 
ATOM   1934 O O   . LYS B 1 84  ? -41.843 4.764   -22.361 1.00 43.23  ? 88  LYS B O   1 
ATOM   1935 C CB  . LYS B 1 84  ? -41.595 1.865   -22.829 1.00 43.11  ? 88  LYS B CB  1 
ATOM   1936 C CG  . LYS B 1 84  ? -42.955 1.317   -22.371 1.00 39.45  ? 88  LYS B CG  1 
ATOM   1937 C CD  . LYS B 1 84  ? -43.928 1.050   -23.523 1.00 51.46  ? 88  LYS B CD  1 
ATOM   1938 C CE  . LYS B 1 84  ? -45.198 0.296   -23.164 1.00 53.90  ? 88  LYS B CE  1 
ATOM   1939 N NZ  . LYS B 1 84  ? -46.224 1.158   -22.519 1.00 56.89  ? 88  LYS B NZ  1 
ATOM   1940 N N   . ASP B 1 85  ? -43.448 4.596   -23.968 1.00 37.76  ? 89  ASP B N   1 
ATOM   1941 C CA  . ASP B 1 85  ? -44.252 5.752   -23.532 1.00 43.38  ? 89  ASP B CA  1 
ATOM   1942 C C   . ASP B 1 85  ? -45.236 5.269   -22.468 1.00 40.81  ? 89  ASP B C   1 
ATOM   1943 O O   . ASP B 1 85  ? -45.353 4.044   -22.239 1.00 37.99  ? 89  ASP B O   1 
ATOM   1944 C CB  . ASP B 1 85  ? -44.952 6.425   -24.720 1.00 41.72  ? 89  ASP B CB  1 
ATOM   1945 C CG  . ASP B 1 85  ? -45.062 7.951   -24.565 1.00 46.06  ? 89  ASP B CG  1 
ATOM   1946 O OD1 . ASP B 1 85  ? -45.245 8.407   -23.408 1.00 38.80  ? 89  ASP B OD1 1 
ATOM   1947 O OD2 . ASP B 1 85  ? -45.039 8.675   -25.607 1.00 45.23  ? 89  ASP B OD2 1 
ATOM   1948 N N   . LEU B 1 86  ? -45.914 6.226   -21.864 1.00 35.69  ? 90  LEU B N   1 
ATOM   1949 C CA  . LEU B 1 86  ? -46.974 6.028   -20.865 1.00 38.43  ? 90  LEU B CA  1 
ATOM   1950 C C   . LEU B 1 86  ? -48.101 5.225   -21.502 1.00 43.83  ? 90  LEU B C   1 
ATOM   1951 O O   . LEU B 1 86  ? -48.270 5.370   -22.694 1.00 38.71  ? 90  LEU B O   1 
ATOM   1952 C CB  . LEU B 1 86  ? -47.481 7.394   -20.411 1.00 42.37  ? 90  LEU B CB  1 
ATOM   1953 C CG  . LEU B 1 86  ? -46.449 8.284   -19.713 1.00 43.40  ? 90  LEU B CG  1 
ATOM   1954 C CD1 . LEU B 1 86  ? -47.094 9.556   -19.205 1.00 46.66  ? 90  LEU B CD1 1 
ATOM   1955 C CD2 . LEU B 1 86  ? -45.833 7.580   -18.540 1.00 45.06  ? 90  LEU B CD2 1 
ATOM   1956 N N   . ASP B 1 87  ? -48.827 4.433   -20.705 1.00 40.69  ? 91  ASP B N   1 
ATOM   1957 C CA  . ASP B 1 87  ? -50.104 3.783   -21.094 1.00 48.80  ? 91  ASP B CA  1 
ATOM   1958 C C   . ASP B 1 87  ? -51.248 4.793   -20.956 1.00 49.17  ? 91  ASP B C   1 
ATOM   1959 O O   . ASP B 1 87  ? -52.217 4.668   -21.656 1.00 53.03  ? 91  ASP B O   1 
ATOM   1960 C CB  . ASP B 1 87  ? -50.370 2.539   -20.229 1.00 49.61  ? 91  ASP B CB  1 
ATOM   1961 C CG  . ASP B 1 87  ? -49.325 1.438   -20.354 1.00 48.80  ? 91  ASP B CG  1 
ATOM   1962 O OD1 . ASP B 1 87  ? -48.851 1.212   -21.446 1.00 53.95  ? 91  ASP B OD1 1 
ATOM   1963 O OD2 . ASP B 1 87  ? -48.921 0.881   -19.340 1.00 66.09  ? 91  ASP B OD2 1 
ATOM   1964 N N   . GLU B 1 88  ? -51.198 5.708   -20.001 1.00 50.20  ? 92  GLU B N   1 
ATOM   1965 C CA  . GLU B 1 88  ? -52.354 6.608   -19.711 1.00 58.07  ? 92  GLU B CA  1 
ATOM   1966 C C   . GLU B 1 88  ? -52.108 8.019   -20.301 1.00 51.52  ? 92  GLU B C   1 
ATOM   1967 O O   . GLU B 1 88  ? -50.919 8.444   -20.428 1.00 42.46  ? 92  GLU B O   1 
ATOM   1968 C CB  . GLU B 1 88  ? -52.639 6.673   -18.201 1.00 72.61  ? 92  GLU B CB  1 
ATOM   1969 C CG  . GLU B 1 88  ? -53.423 5.484   -17.605 1.00 85.99  ? 92  GLU B CG  1 
ATOM   1970 C CD  . GLU B 1 88  ? -54.153 4.462   -18.499 1.00 88.58  ? 92  GLU B CD  1 
ATOM   1971 O OE1 . GLU B 1 88  ? -55.101 4.819   -19.255 1.00 75.41  ? 92  GLU B OE1 1 
ATOM   1972 O OE2 . GLU B 1 88  ? -53.815 3.268   -18.400 1.00 87.21  ? 92  GLU B OE2 1 
ATOM   1973 N N   . ASP B 1 89  ? -53.204 8.697   -20.661 1.00 47.33  ? 93  ASP B N   1 
ATOM   1974 C CA  . ASP B 1 89  ? -53.298 10.160  -20.951 1.00 47.69  ? 93  ASP B CA  1 
ATOM   1975 C C   . ASP B 1 89  ? -53.046 10.987  -19.684 1.00 46.77  ? 93  ASP B C   1 
ATOM   1976 O O   . ASP B 1 89  ? -53.533 10.595  -18.611 1.00 44.85  ? 93  ASP B O   1 
ATOM   1977 C CB  . ASP B 1 89  ? -54.674 10.490  -21.529 1.00 49.08  ? 93  ASP B CB  1 
ATOM   1978 C CG  . ASP B 1 89  ? -54.877 9.812   -22.883 1.00 54.66  ? 93  ASP B CG  1 
ATOM   1979 O OD1 . ASP B 1 89  ? -53.925 9.788   -23.679 1.00 53.99  ? 93  ASP B OD1 1 
ATOM   1980 O OD2 . ASP B 1 89  ? -55.946 9.281   -23.110 1.00 67.20  ? 93  ASP B OD2 1 
ATOM   1981 N N   . ILE B 1 90  ? -52.338 12.108  -19.805 1.00 44.07  ? 94  ILE B N   1 
ATOM   1982 C CA  . ILE B 1 90  ? -52.018 12.991  -18.643 1.00 45.22  ? 94  ILE B CA  1 
ATOM   1983 C C   . ILE B 1 90  ? -52.664 14.361  -18.818 1.00 46.96  ? 94  ILE B C   1 
ATOM   1984 O O   . ILE B 1 90  ? -52.594 15.109  -17.852 1.00 49.31  ? 94  ILE B O   1 
ATOM   1985 C CB  . ILE B 1 90  ? -50.497 13.108  -18.397 1.00 39.81  ? 94  ILE B CB  1 
ATOM   1986 C CG1 . ILE B 1 90  ? -49.719 13.627  -19.606 1.00 41.37  ? 94  ILE B CG1 1 
ATOM   1987 C CG2 . ILE B 1 90  ? -49.933 11.775  -17.904 1.00 42.14  ? 94  ILE B CG2 1 
ATOM   1988 C CD1 . ILE B 1 90  ? -48.280 13.997  -19.272 1.00 38.80  ? 94  ILE B CD1 1 
ATOM   1989 N N   . ARG B 1 91  ? -53.262 14.670  -19.976 1.00 47.58  ? 95  ARG B N   1 
ATOM   1990 C CA  . ARG B 1 91  ? -53.838 16.010  -20.227 1.00 55.42  ? 95  ARG B CA  1 
ATOM   1991 C C   . ARG B 1 91  ? -54.767 16.328  -19.046 1.00 47.95  ? 95  ARG B C   1 
ATOM   1992 O O   . ARG B 1 91  ? -55.599 15.498  -18.723 1.00 48.33  ? 95  ARG B O   1 
ATOM   1993 C CB  . ARG B 1 91  ? -54.567 16.096  -21.582 1.00 60.07  ? 95  ARG B CB  1 
ATOM   1994 C CG  . ARG B 1 91  ? -55.485 17.319  -21.729 1.00 65.36  ? 95  ARG B CG  1 
ATOM   1995 C CD  . ARG B 1 91  ? -56.273 17.403  -23.044 1.00 71.18  ? 95  ARG B CD  1 
ATOM   1996 N NE  . ARG B 1 91  ? -55.298 17.469  -24.115 1.00 74.39  ? 95  ARG B NE  1 
ATOM   1997 C CZ  . ARG B 1 91  ? -54.720 18.579  -24.565 1.00 77.62  ? 95  ARG B CZ  1 
ATOM   1998 N NH1 . ARG B 1 91  ? -55.085 19.767  -24.110 1.00 84.64  ? 95  ARG B NH1 1 
ATOM   1999 N NH2 . ARG B 1 91  ? -53.791 18.496  -25.499 1.00 69.91  ? 95  ARG B NH2 1 
ATOM   2000 N N   . GLY B 1 92  ? -54.614 17.481  -18.388 1.00 45.65  ? 96  GLY B N   1 
ATOM   2001 C CA  . GLY B 1 92  ? -55.546 17.893  -17.317 1.00 45.98  ? 96  GLY B CA  1 
ATOM   2002 C C   . GLY B 1 92  ? -55.338 17.161  -15.987 1.00 48.93  ? 96  GLY B C   1 
ATOM   2003 O O   . GLY B 1 92  ? -56.143 17.341  -15.084 1.00 49.84  ? 96  GLY B O   1 
ATOM   2004 N N   . LYS B 1 93  ? -54.250 16.432  -15.803 1.00 45.27  ? 97  LYS B N   1 
ATOM   2005 C CA  . LYS B 1 93  ? -53.997 15.678  -14.559 1.00 42.09  ? 97  LYS B CA  1 
ATOM   2006 C C   . LYS B 1 93  ? -52.817 16.315  -13.824 1.00 41.00  ? 97  LYS B C   1 
ATOM   2007 O O   . LYS B 1 93  ? -51.938 16.841  -14.475 1.00 40.98  ? 97  LYS B O   1 
ATOM   2008 C CB  . LYS B 1 93  ? -53.705 14.210  -14.913 1.00 45.69  ? 97  LYS B CB  1 
ATOM   2009 C CG  . LYS B 1 93  ? -54.902 13.502  -15.533 1.00 52.11  ? 97  LYS B CG  1 
ATOM   2010 C CD  . LYS B 1 93  ? -54.768 12.021  -15.811 1.00 56.30  ? 97  LYS B CD  1 
ATOM   2011 C CE  . LYS B 1 93  ? -55.991 11.526  -16.563 1.00 59.18  ? 97  LYS B CE  1 
ATOM   2012 N NZ  . LYS B 1 93  ? -55.901 10.083  -16.848 1.00 72.03  ? 97  LYS B NZ  1 
ATOM   2013 N N   . ASP B 1 94  ? -52.735 16.107  -12.516 1.00 39.14  ? 98  ASP B N   1 
ATOM   2014 C CA  . ASP B 1 94  ? -51.497 16.382  -11.750 1.00 41.13  ? 98  ASP B CA  1 
ATOM   2015 C C   . ASP B 1 94  ? -50.528 15.235  -12.003 1.00 46.73  ? 98  ASP B C   1 
ATOM   2016 O O   . ASP B 1 94  ? -50.887 14.091  -11.733 1.00 41.63  ? 98  ASP B O   1 
ATOM   2017 C CB  . ASP B 1 94  ? -51.787 16.588  -10.259 1.00 40.65  ? 98  ASP B CB  1 
ATOM   2018 C CG  . ASP B 1 94  ? -52.539 17.884  -10.011 1.00 48.08  ? 98  ASP B CG  1 
ATOM   2019 O OD1 . ASP B 1 94  ? -52.146 18.935  -10.606 1.00 44.33  ? 98  ASP B OD1 1 
ATOM   2020 O OD2 . ASP B 1 94  ? -53.532 17.815  -9.292  1.00 46.09  ? 98  ASP B OD2 1 
ATOM   2021 N N   . VAL B 1 95  ? -49.322 15.548  -12.451 1.00 41.05  ? 99  VAL B N   1 
ATOM   2022 C CA  . VAL B 1 95  ? -48.328 14.519  -12.776 1.00 38.07  ? 99  VAL B CA  1 
ATOM   2023 C C   . VAL B 1 95  ? -47.131 14.736  -11.885 1.00 40.56  ? 99  VAL B C   1 
ATOM   2024 O O   . VAL B 1 95  ? -46.590 15.851  -11.879 1.00 43.74  ? 99  VAL B O   1 
ATOM   2025 C CB  . VAL B 1 95  ? -47.949 14.609  -14.254 1.00 39.40  ? 99  VAL B CB  1 
ATOM   2026 C CG1 . VAL B 1 95  ? -46.833 13.642  -14.547 1.00 38.28  ? 99  VAL B CG1 1 
ATOM   2027 C CG2 . VAL B 1 95  ? -49.150 14.426  -15.143 1.00 40.14  ? 99  VAL B CG2 1 
ATOM   2028 N N   . LEU B 1 96  ? -46.703 13.678  -11.229 1.00 37.41  ? 100 LEU B N   1 
ATOM   2029 C CA  . LEU B 1 96  ? -45.433 13.601  -10.509 1.00 36.80  ? 100 LEU B CA  1 
ATOM   2030 C C   . LEU B 1 96  ? -44.534 12.590  -11.194 1.00 40.06  ? 100 LEU B C   1 
ATOM   2031 O O   . LEU B 1 96  ? -44.812 11.358  -11.104 1.00 42.74  ? 100 LEU B O   1 
ATOM   2032 C CB  . LEU B 1 96  ? -45.718 13.243  -9.040  1.00 42.17  ? 100 LEU B CB  1 
ATOM   2033 C CG  . LEU B 1 96  ? -44.508 13.229  -8.109  1.00 42.70  ? 100 LEU B CG  1 
ATOM   2034 C CD1 . LEU B 1 96  ? -43.959 14.649  -7.970  1.00 45.04  ? 100 LEU B CD1 1 
ATOM   2035 C CD2 . LEU B 1 96  ? -44.861 12.661  -6.718  1.00 43.77  ? 100 LEU B CD2 1 
ATOM   2036 N N   . ILE B 1 97  ? -43.434 13.076  -11.755 1.00 36.14  ? 101 ILE B N   1 
ATOM   2037 C CA  . ILE B 1 97  ? -42.329 12.229  -12.259 1.00 37.49  ? 101 ILE B CA  1 
ATOM   2038 C C   . ILE B 1 97  ? -41.582 11.676  -11.051 1.00 43.81  ? 101 ILE B C   1 
ATOM   2039 O O   . ILE B 1 97  ? -41.149 12.499  -10.204 1.00 39.95  ? 101 ILE B O   1 
ATOM   2040 C CB  . ILE B 1 97  ? -41.426 13.021  -13.213 1.00 36.87  ? 101 ILE B CB  1 
ATOM   2041 C CG1 . ILE B 1 97  ? -42.235 13.547  -14.406 1.00 41.51  ? 101 ILE B CG1 1 
ATOM   2042 C CG2 . ILE B 1 97  ? -40.281 12.142  -13.654 1.00 39.99  ? 101 ILE B CG2 1 
ATOM   2043 C CD1 . ILE B 1 97  ? -41.497 14.561  -15.252 1.00 45.34  ? 101 ILE B CD1 1 
ATOM   2044 N N   . VAL B 1 98  ? -41.362 10.352  -11.027 1.00 35.59  ? 102 VAL B N   1 
ATOM   2045 C CA  . VAL B 1 98  ? -40.642 9.645   -9.941  1.00 33.56  ? 102 VAL B CA  1 
ATOM   2046 C C   . VAL B 1 98  ? -39.345 9.066   -10.482 1.00 39.09  ? 102 VAL B C   1 
ATOM   2047 O O   . VAL B 1 98  ? -39.348 8.213   -11.435 1.00 38.10  ? 102 VAL B O   1 
ATOM   2048 C CB  . VAL B 1 98  ? -41.553 8.583   -9.318  1.00 36.28  ? 102 VAL B CB  1 
ATOM   2049 C CG1 . VAL B 1 98  ? -40.829 7.842   -8.238  1.00 33.64  ? 102 VAL B CG1 1 
ATOM   2050 C CG2 . VAL B 1 98  ? -42.869 9.165   -8.839  1.00 37.67  ? 102 VAL B CG2 1 
ATOM   2051 N N   . GLU B 1 99  ? -38.237 9.464   -9.876  1.00 38.86  ? 103 GLU B N   1 
ATOM   2052 C CA  . GLU B 1 99  ? -36.887 9.165   -10.405 1.00 38.29  ? 103 GLU B CA  1 
ATOM   2053 C C   . GLU B 1 99  ? -36.020 8.715   -9.238  1.00 37.76  ? 103 GLU B C   1 
ATOM   2054 O O   . GLU B 1 99  ? -36.129 9.330   -8.153  1.00 37.85  ? 103 GLU B O   1 
ATOM   2055 C CB  . GLU B 1 99  ? -36.362 10.456  -11.052 1.00 46.96  ? 103 GLU B CB  1 
ATOM   2056 C CG  . GLU B 1 99  ? -34.906 10.415  -11.435 1.00 55.96  ? 103 GLU B CG  1 
ATOM   2057 C CD  . GLU B 1 99  ? -34.575 9.443   -12.564 1.00 60.17  ? 103 GLU B CD  1 
ATOM   2058 O OE1 . GLU B 1 99  ? -33.434 9.488   -13.071 1.00 68.36  ? 103 GLU B OE1 1 
ATOM   2059 O OE2 . GLU B 1 99  ? -35.466 8.680   -12.963 1.00 58.91  ? 103 GLU B OE2 1 
ATOM   2060 N N   . ASP B 1 100 ? -35.171 7.721   -9.455  1.00 37.57  ? 104 ASP B N   1 
ATOM   2061 C CA  . ASP B 1 100 ? -34.149 7.237   -8.491  1.00 42.92  ? 104 ASP B CA  1 
ATOM   2062 C C   . ASP B 1 100 ? -33.105 8.326   -8.204  1.00 46.04  ? 104 ASP B C   1 
ATOM   2063 O O   . ASP B 1 100 ? -32.746 8.492   -7.001  1.00 42.84  ? 104 ASP B O   1 
ATOM   2064 C CB  . ASP B 1 100 ? -33.439 5.958   -8.953  1.00 43.49  ? 104 ASP B CB  1 
ATOM   2065 C CG  . ASP B 1 100 ? -32.946 5.922   -10.406 1.00 52.63  ? 104 ASP B CG  1 
ATOM   2066 O OD1 . ASP B 1 100 ? -33.254 6.857   -11.194 1.00 65.60  ? 104 ASP B OD1 1 
ATOM   2067 O OD2 . ASP B 1 100 ? -32.256 4.947   -10.757 1.00 68.43  ? 104 ASP B OD2 1 
ATOM   2068 N N   . ILE B 1 101 ? -32.533 8.943   -9.244  1.00 42.65  ? 105 ILE B N   1 
ATOM   2069 C CA  . ILE B 1 101 ? -31.360 9.842   -9.073  1.00 46.99  ? 105 ILE B CA  1 
ATOM   2070 C C   . ILE B 1 101 ? -31.346 10.937  -10.135 1.00 48.07  ? 105 ILE B C   1 
ATOM   2071 O O   . ILE B 1 101 ? -31.606 10.619  -11.319 1.00 49.53  ? 105 ILE B O   1 
ATOM   2072 C CB  . ILE B 1 101 ? -30.039 9.051   -9.014  1.00 49.43  ? 105 ILE B CB  1 
ATOM   2073 C CG1 . ILE B 1 101 ? -28.856 10.015  -8.856  1.00 53.27  ? 105 ILE B CG1 1 
ATOM   2074 C CG2 . ILE B 1 101 ? -29.860 8.140   -10.211 1.00 53.40  ? 105 ILE B CG2 1 
ATOM   2075 C CD1 . ILE B 1 101 ? -27.690 9.459   -8.048  1.00 54.62  ? 105 ILE B CD1 1 
ATOM   2076 N N   . ILE B 1 102 ? -31.083 12.190  -9.711  1.00 49.23  ? 106 ILE B N   1 
ATOM   2077 C CA  . ILE B 1 102 ? -30.766 13.351  -10.605 1.00 46.51  ? 106 ILE B CA  1 
ATOM   2078 C C   . ILE B 1 102 ? -29.283 13.678  -10.417 1.00 50.26  ? 106 ILE B C   1 
ATOM   2079 O O   . ILE B 1 102 ? -28.855 13.848  -9.246  1.00 44.68  ? 106 ILE B O   1 
ATOM   2080 C CB  . ILE B 1 102 ? -31.648 14.581  -10.328 1.00 51.00  ? 106 ILE B CB  1 
ATOM   2081 C CG1 . ILE B 1 102 ? -33.139 14.247  -10.274 1.00 62.04  ? 106 ILE B CG1 1 
ATOM   2082 C CG2 . ILE B 1 102 ? -31.374 15.698  -11.344 1.00 48.60  ? 106 ILE B CG2 1 
ATOM   2083 C CD1 . ILE B 1 102 ? -33.844 14.167  -11.621 1.00 64.31  ? 106 ILE B CD1 1 
ATOM   2084 N N   . ASP B 1 103 ? -28.498 13.712  -11.498 1.00 45.36  ? 107 ASP B N   1 
ATOM   2085 C CA  . ASP B 1 103 ? -27.078 14.162  -11.429 1.00 42.34  ? 107 ASP B CA  1 
ATOM   2086 C C   . ASP B 1 103 ? -26.913 15.346  -12.387 1.00 49.06  ? 107 ASP B C   1 
ATOM   2087 O O   . ASP B 1 103 ? -27.038 16.534  -11.928 1.00 42.27  ? 107 ASP B O   1 
ATOM   2088 C CB  . ASP B 1 103 ? -26.090 13.004  -11.534 1.00 48.13  ? 107 ASP B CB  1 
ATOM   2089 C CG  . ASP B 1 103 ? -26.428 11.971  -12.586 1.00 54.18  ? 107 ASP B CG  1 
ATOM   2090 O OD1 . ASP B 1 103 ? -26.996 12.371  -13.620 1.00 50.07  ? 107 ASP B OD1 1 
ATOM   2091 O OD2 . ASP B 1 103 ? -26.125 10.794  -12.344 1.00 52.19  ? 107 ASP B OD2 1 
ATOM   2092 N N   . SER B 1 104 ? -26.767 15.092  -13.679 1.00 46.39  ? 108 SER B N   1 
ATOM   2093 C CA  . SER B 1 104 ? -26.596 16.199  -14.657 1.00 49.95  ? 108 SER B CA  1 
ATOM   2094 C C   . SER B 1 104 ? -27.907 16.980  -14.781 1.00 46.86  ? 108 SER B C   1 
ATOM   2095 O O   . SER B 1 104 ? -27.858 18.198  -15.063 1.00 48.89  ? 108 SER B O   1 
ATOM   2096 C CB  . SER B 1 104 ? -26.149 15.640  -15.992 1.00 52.06  ? 108 SER B CB  1 
ATOM   2097 O OG  . SER B 1 104 ? -27.254 14.997  -16.622 1.00 52.78  ? 108 SER B OG  1 
ATOM   2098 N N   . GLY B 1 105 ? -29.057 16.306  -14.639 1.00 44.70  ? 109 GLY B N   1 
ATOM   2099 C CA  . GLY B 1 105 ? -30.370 16.922  -14.960 1.00 47.42  ? 109 GLY B CA  1 
ATOM   2100 C C   . GLY B 1 105 ? -30.775 16.832  -16.434 1.00 43.72  ? 109 GLY B C   1 
ATOM   2101 O O   . GLY B 1 105 ? -31.901 17.223  -16.761 1.00 47.21  ? 109 GLY B O   1 
ATOM   2102 N N   . ASN B 1 106 ? -29.928 16.306  -17.315 1.00 51.61  ? 110 ASN B N   1 
ATOM   2103 C CA  . ASN B 1 106 ? -30.194 16.294  -18.785 1.00 50.00  ? 110 ASN B CA  1 
ATOM   2104 C C   . ASN B 1 106 ? -31.403 15.412  -19.125 1.00 48.65  ? 110 ASN B C   1 
ATOM   2105 O O   . ASN B 1 106 ? -32.286 15.883  -19.856 1.00 51.20  ? 110 ASN B O   1 
ATOM   2106 C CB  . ASN B 1 106 ? -28.947 15.901  -19.575 1.00 53.52  ? 110 ASN B CB  1 
ATOM   2107 C CG  . ASN B 1 106 ? -27.827 16.917  -19.429 1.00 63.15  ? 110 ASN B CG  1 
ATOM   2108 O OD1 . ASN B 1 106 ? -28.059 18.125  -19.334 1.00 57.40  ? 110 ASN B OD1 1 
ATOM   2109 N ND2 . ASN B 1 106 ? -26.599 16.431  -19.351 1.00 65.46  ? 110 ASN B ND2 1 
ATOM   2110 N N   . THR B 1 107 ? -31.489 14.173  -18.640 1.00 45.94  ? 111 THR B N   1 
ATOM   2111 C CA  . THR B 1 107 ? -32.612 13.281  -19.037 1.00 45.22  ? 111 THR B CA  1 
ATOM   2112 C C   . THR B 1 107 ? -33.912 13.850  -18.487 1.00 44.91  ? 111 THR B C   1 
ATOM   2113 O O   . THR B 1 107 ? -34.866 14.071  -19.268 1.00 43.76  ? 111 THR B O   1 
ATOM   2114 C CB  . THR B 1 107 ? -32.354 11.842  -18.599 1.00 49.15  ? 111 THR B CB  1 
ATOM   2115 O OG1 . THR B 1 107 ? -31.102 11.553  -19.196 1.00 48.40  ? 111 THR B OG1 1 
ATOM   2116 C CG2 . THR B 1 107 ? -33.415 10.862  -19.052 1.00 50.73  ? 111 THR B CG2 1 
ATOM   2117 N N   . LEU B 1 108 ? -33.937 14.104  -17.181 1.00 44.88  ? 112 LEU B N   1 
ATOM   2118 C CA  . LEU B 1 108 ? -35.149 14.606  -16.513 1.00 47.43  ? 112 LEU B CA  1 
ATOM   2119 C C   . LEU B 1 108 ? -35.626 15.888  -17.194 1.00 44.72  ? 112 LEU B C   1 
ATOM   2120 O O   . LEU B 1 108 ? -36.840 16.071  -17.331 1.00 39.42  ? 112 LEU B O   1 
ATOM   2121 C CB  . LEU B 1 108 ? -34.890 14.806  -15.017 1.00 48.19  ? 112 LEU B CB  1 
ATOM   2122 C CG  . LEU B 1 108 ? -35.497 13.712  -14.148 1.00 63.64  ? 112 LEU B CG  1 
ATOM   2123 C CD1 . LEU B 1 108 ? -36.992 13.597  -14.381 1.00 57.08  ? 112 LEU B CD1 1 
ATOM   2124 C CD2 . LEU B 1 108 ? -34.808 12.372  -14.400 1.00 66.15  ? 112 LEU B CD2 1 
ATOM   2125 N N   . SER B 1 109 ? -34.709 16.779  -17.543 1.00 46.25  ? 113 SER B N   1 
ATOM   2126 C CA  . SER B 1 109 ? -35.067 18.070  -18.196 1.00 48.91  ? 113 SER B CA  1 
ATOM   2127 C C   . SER B 1 109 ? -35.849 17.769  -19.486 1.00 40.30  ? 113 SER B C   1 
ATOM   2128 O O   . SER B 1 109 ? -36.954 18.329  -19.694 1.00 43.43  ? 113 SER B O   1 
ATOM   2129 C CB  . SER B 1 109 ? -33.781 18.866  -18.453 1.00 49.17  ? 113 SER B CB  1 
ATOM   2130 O OG  . SER B 1 109 ? -34.029 19.918  -19.335 1.00 62.13  ? 113 SER B OG  1 
ATOM   2131 N N   . LYS B 1 110 ? -35.324 16.867  -20.314 1.00 43.97  ? 114 LYS B N   1 
ATOM   2132 C CA  . LYS B 1 110 ? -35.909 16.522  -21.642 1.00 46.15  ? 114 LYS B CA  1 
ATOM   2133 C C   . LYS B 1 110 ? -37.216 15.747  -21.436 1.00 43.50  ? 114 LYS B C   1 
ATOM   2134 O O   . LYS B 1 110 ? -38.213 16.041  -22.103 1.00 44.14  ? 114 LYS B O   1 
ATOM   2135 C CB  . LYS B 1 110 ? -34.887 15.757  -22.484 1.00 49.63  ? 114 LYS B CB  1 
ATOM   2136 C CG  . LYS B 1 110 ? -33.615 16.524  -22.800 1.00 57.47  ? 114 LYS B CG  1 
ATOM   2137 C CD  . LYS B 1 110 ? -33.862 17.754  -23.645 1.00 68.14  ? 114 LYS B CD  1 
ATOM   2138 C CE  . LYS B 1 110 ? -32.619 18.597  -23.825 1.00 72.78  ? 114 LYS B CE  1 
ATOM   2139 N NZ  . LYS B 1 110 ? -32.984 19.842  -24.532 1.00 83.55  ? 114 LYS B NZ  1 
ATOM   2140 N N   . VAL B 1 111 ? -37.278 14.879  -20.426 1.00 49.84  ? 115 VAL B N   1 
ATOM   2141 C CA  . VAL B 1 111 ? -38.542 14.127  -20.168 1.00 40.74  ? 115 VAL B CA  1 
ATOM   2142 C C   . VAL B 1 111 ? -39.628 15.098  -19.733 1.00 40.19  ? 115 VAL B C   1 
ATOM   2143 O O   . VAL B 1 111 ? -40.795 14.947  -20.141 1.00 39.41  ? 115 VAL B O   1 
ATOM   2144 C CB  . VAL B 1 111 ? -38.347 13.009  -19.135 1.00 44.67  ? 115 VAL B CB  1 
ATOM   2145 C CG1 . VAL B 1 111 ? -39.695 12.496  -18.671 1.00 42.47  ? 115 VAL B CG1 1 
ATOM   2146 C CG2 . VAL B 1 111 ? -37.457 11.902  -19.664 1.00 43.72  ? 115 VAL B CG2 1 
ATOM   2147 N N   A ARG B 1 112 ? -39.301 16.046  -18.859 0.50 40.35  ? 116 ARG B N   1 
ATOM   2148 N N   C ARG B 1 112 ? -39.249 16.044  -18.866 0.50 42.44  ? 116 ARG B N   1 
ATOM   2149 C CA  A ARG B 1 112 ? -40.301 17.043  -18.416 0.50 40.16  ? 116 ARG B CA  1 
ATOM   2150 C CA  C ARG B 1 112 ? -40.129 17.131  -18.364 0.50 44.34  ? 116 ARG B CA  1 
ATOM   2151 C C   A ARG B 1 112 ? -40.790 17.838  -19.639 0.50 36.98  ? 116 ARG B C   1 
ATOM   2152 C C   C ARG B 1 112 ? -40.726 17.876  -19.570 0.50 39.67  ? 116 ARG B C   1 
ATOM   2153 O O   A ARG B 1 112 ? -42.028 18.051  -19.742 0.50 34.69  ? 116 ARG B O   1 
ATOM   2154 O O   C ARG B 1 112 ? -41.962 18.080  -19.580 0.50 40.85  ? 116 ARG B O   1 
ATOM   2155 C CB  A ARG B 1 112 ? -39.733 17.962  -17.322 0.50 40.58  ? 116 ARG B CB  1 
ATOM   2156 C CB  C ARG B 1 112 ? -39.345 18.057  -17.410 0.50 43.28  ? 116 ARG B CB  1 
ATOM   2157 C CG  A ARG B 1 112 ? -40.691 19.081  -16.959 0.50 38.29  ? 116 ARG B CG  1 
ATOM   2158 C CG  C ARG B 1 112 ? -40.121 18.461  -16.166 0.50 42.00  ? 116 ARG B CG  1 
ATOM   2159 C CD  A ARG B 1 112 ? -40.170 20.081  -15.931 0.50 42.60  ? 116 ARG B CD  1 
ATOM   2160 C CD  C ARG B 1 112 ? -39.527 19.516  -15.208 0.50 39.13  ? 116 ARG B CD  1 
ATOM   2161 N NE  A ARG B 1 112 ? -41.266 20.604  -15.124 0.50 39.53  ? 116 ARG B NE  1 
ATOM   2162 N NE  C ARG B 1 112 ? -40.635 20.224  -14.548 0.50 37.09  ? 116 ARG B NE  1 
ATOM   2163 C CZ  A ARG B 1 112 ? -42.146 21.488  -15.563 0.50 40.44  ? 116 ARG B CZ  1 
ATOM   2164 C CZ  C ARG B 1 112 ? -40.844 20.338  -13.236 0.50 37.32  ? 116 ARG B CZ  1 
ATOM   2165 N NH1 A ARG B 1 112 ? -42.048 21.946  -16.796 0.50 34.67  ? 116 ARG B NH1 1 
ATOM   2166 N NH1 C ARG B 1 112 ? -41.900 21.002  -12.816 0.50 44.26  ? 116 ARG B NH1 1 
ATOM   2167 N NH2 A ARG B 1 112 ? -43.107 21.904  -14.761 0.50 38.59  ? 116 ARG B NH2 1 
ATOM   2168 N NH2 C ARG B 1 112 ? -39.998 19.856  -12.350 0.50 36.88  ? 116 ARG B NH2 1 
ATOM   2169 N N   . GLU B 1 113 ? -39.905 18.239  -20.563 1.00 38.37  ? 117 GLU B N   1 
ATOM   2170 C CA  . GLU B 1 113 ? -40.376 19.011  -21.775 1.00 41.46  ? 117 GLU B CA  1 
ATOM   2171 C C   . GLU B 1 113 ? -41.294 18.149  -22.643 1.00 42.78  ? 117 GLU B C   1 
ATOM   2172 O O   . GLU B 1 113 ? -42.388 18.588  -23.027 1.00 40.92  ? 117 GLU B O   1 
ATOM   2173 C CB  . GLU B 1 113 ? -39.252 19.470  -22.692 1.00 44.27  ? 117 GLU B CB  1 
ATOM   2174 C CG  . GLU B 1 113 ? -38.243 20.391  -22.058 1.00 52.57  ? 117 GLU B CG  1 
ATOM   2175 C CD  . GLU B 1 113 ? -37.046 20.659  -22.972 1.00 58.98  ? 117 GLU B CD  1 
ATOM   2176 O OE1 . GLU B 1 113 ? -36.655 19.774  -23.798 1.00 61.90  ? 117 GLU B OE1 1 
ATOM   2177 O OE2 . GLU B 1 113 ? -36.501 21.735  -22.852 1.00 71.32  ? 117 GLU B OE2 1 
ATOM   2178 N N   . ILE B 1 114 ? -40.935 16.882  -22.869 1.00 42.49  ? 118 ILE B N   1 
ATOM   2179 C CA  . ILE B 1 114 ? -41.873 15.969  -23.588 1.00 36.98  ? 118 ILE B CA  1 
ATOM   2180 C C   . ILE B 1 114 ? -43.230 15.961  -22.915 1.00 32.90  ? 118 ILE B C   1 
ATOM   2181 O O   . ILE B 1 114 ? -44.288 16.131  -23.623 1.00 39.10  ? 118 ILE B O   1 
ATOM   2182 C CB  . ILE B 1 114 ? -41.271 14.547  -23.723 1.00 40.62  ? 118 ILE B CB  1 
ATOM   2183 C CG1 . ILE B 1 114 ? -40.092 14.602  -24.689 1.00 40.76  ? 118 ILE B CG1 1 
ATOM   2184 C CG2 . ILE B 1 114 ? -42.327 13.553  -24.151 1.00 46.42  ? 118 ILE B CG2 1 
ATOM   2185 C CD1 . ILE B 1 114 ? -38.971 13.540  -24.473 1.00 41.71  ? 118 ILE B CD1 1 
ATOM   2186 N N   . LEU B 1 115 ? -43.303 15.692  -21.606 1.00 38.85  ? 119 LEU B N   1 
ATOM   2187 C CA  . LEU B 1 115 ? -44.643 15.515  -20.980 1.00 35.87  ? 119 LEU B CA  1 
ATOM   2188 C C   . LEU B 1 115 ? -45.408 16.860  -20.917 1.00 38.53  ? 119 LEU B C   1 
ATOM   2189 O O   . LEU B 1 115 ? -46.684 16.857  -20.897 1.00 35.58  ? 119 LEU B O   1 
ATOM   2190 C CB  . LEU B 1 115 ? -44.504 14.910  -19.576 1.00 41.39  ? 119 LEU B CB  1 
ATOM   2191 C CG  . LEU B 1 115 ? -43.944 13.485  -19.480 1.00 44.62  ? 119 LEU B CG  1 
ATOM   2192 C CD1 . LEU B 1 115 ? -43.968 13.025  -18.036 1.00 43.47  ? 119 LEU B CD1 1 
ATOM   2193 C CD2 . LEU B 1 115 ? -44.722 12.510  -20.341 1.00 43.43  ? 119 LEU B CD2 1 
ATOM   2194 N N   . SER B 1 116 ? -44.683 17.977  -20.790 1.00 42.40  ? 120 SER B N   1 
ATOM   2195 C CA  . SER B 1 116 ? -45.265 19.353  -20.790 1.00 43.01  ? 120 SER B CA  1 
ATOM   2196 C C   . SER B 1 116 ? -46.124 19.577  -22.049 1.00 39.37  ? 120 SER B C   1 
ATOM   2197 O O   . SER B 1 116 ? -47.216 20.095  -21.932 1.00 40.85  ? 120 SER B O   1 
ATOM   2198 C CB  . SER B 1 116 ? -44.149 20.364  -20.692 1.00 46.74  ? 120 SER B CB  1 
ATOM   2199 O OG  . SER B 1 116 ? -44.724 21.612  -20.474 1.00 55.15  ? 120 SER B OG  1 
ATOM   2200 N N   . LEU B 1 117 ? -45.702 19.059  -23.200 1.00 47.71  ? 121 LEU B N   1 
ATOM   2201 C CA  . LEU B 1 117 ? -46.463 19.171  -24.479 1.00 45.69  ? 121 LEU B CA  1 
ATOM   2202 C C   . LEU B 1 117 ? -47.849 18.588  -24.322 1.00 43.35  ? 121 LEU B C   1 
ATOM   2203 O O   . LEU B 1 117 ? -48.706 18.963  -25.114 1.00 45.10  ? 121 LEU B O   1 
ATOM   2204 C CB  . LEU B 1 117 ? -45.750 18.477  -25.643 1.00 45.39  ? 121 LEU B CB  1 
ATOM   2205 C CG  . LEU B 1 117 ? -44.400 19.071  -26.020 1.00 52.92  ? 121 LEU B CG  1 
ATOM   2206 C CD1 . LEU B 1 117 ? -43.767 18.285  -27.164 1.00 49.31  ? 121 LEU B CD1 1 
ATOM   2207 C CD2 . LEU B 1 117 ? -44.536 20.559  -26.386 1.00 49.47  ? 121 LEU B CD2 1 
ATOM   2208 N N   . ARG B 1 118 ? -48.107 17.751  -23.323 1.00 43.15  ? 122 ARG B N   1 
ATOM   2209 C CA  . ARG B 1 118 ? -49.415 17.046  -23.251 1.00 44.26  ? 122 ARG B CA  1 
ATOM   2210 C C   . ARG B 1 118 ? -50.378 17.842  -22.395 1.00 44.01  ? 122 ARG B C   1 
ATOM   2211 O O   . ARG B 1 118 ? -51.515 17.381  -22.218 1.00 44.01  ? 122 ARG B O   1 
ATOM   2212 C CB  . ARG B 1 118 ? -49.192 15.617  -22.748 1.00 45.28  ? 122 ARG B CB  1 
ATOM   2213 C CG  . ARG B 1 118 ? -48.246 14.861  -23.664 1.00 44.09  ? 122 ARG B CG  1 
ATOM   2214 C CD  . ARG B 1 118 ? -48.057 13.411  -23.306 1.00 47.30  ? 122 ARG B CD  1 
ATOM   2215 N NE  . ARG B 1 118 ? -46.919 12.880  -24.032 1.00 49.92  ? 122 ARG B NE  1 
ATOM   2216 C CZ  . ARG B 1 118 ? -46.503 11.627  -23.951 1.00 49.17  ? 122 ARG B CZ  1 
ATOM   2217 N NH1 . ARG B 1 118 ? -47.156 10.748  -23.202 1.00 53.62  ? 122 ARG B NH1 1 
ATOM   2218 N NH2 . ARG B 1 118 ? -45.439 11.273  -24.632 1.00 47.26  ? 122 ARG B NH2 1 
ATOM   2219 N N   . GLU B 1 119 ? -49.922 18.990  -21.871 1.00 47.35  ? 123 GLU B N   1 
ATOM   2220 C CA  . GLU B 1 119 ? -50.763 19.922  -21.080 1.00 48.71  ? 123 GLU B CA  1 
ATOM   2221 C C   . GLU B 1 119 ? -51.355 19.183  -19.892 1.00 45.21  ? 123 GLU B C   1 
ATOM   2222 O O   . GLU B 1 119 ? -52.559 19.236  -19.633 1.00 43.94  ? 123 GLU B O   1 
ATOM   2223 C CB  . GLU B 1 119 ? -51.785 20.591  -22.008 1.00 52.74  ? 123 GLU B CB  1 
ATOM   2224 C CG  . GLU B 1 119 ? -51.065 21.413  -23.072 1.00 60.35  ? 123 GLU B CG  1 
ATOM   2225 C CD  . GLU B 1 119 ? -51.945 22.210  -24.014 1.00 75.41  ? 123 GLU B CD  1 
ATOM   2226 O OE1 . GLU B 1 119 ? -52.979 21.681  -24.424 1.00 70.95  ? 123 GLU B OE1 1 
ATOM   2227 O OE2 . GLU B 1 119 ? -51.573 23.349  -24.351 1.00 91.82  ? 123 GLU B OE2 1 
ATOM   2228 N N   . PRO B 1 120 ? -50.497 18.609  -19.025 1.00 40.48  ? 124 PRO B N   1 
ATOM   2229 C CA  . PRO B 1 120 ? -50.953 18.233  -17.688 1.00 42.99  ? 124 PRO B CA  1 
ATOM   2230 C C   . PRO B 1 120 ? -51.442 19.504  -16.967 1.00 49.91  ? 124 PRO B C   1 
ATOM   2231 O O   . PRO B 1 120 ? -50.894 20.567  -17.231 1.00 42.40  ? 124 PRO B O   1 
ATOM   2232 C CB  . PRO B 1 120 ? -49.698 17.737  -16.976 1.00 41.08  ? 124 PRO B CB  1 
ATOM   2233 C CG  . PRO B 1 120 ? -48.575 18.384  -17.720 1.00 43.53  ? 124 PRO B CG  1 
ATOM   2234 C CD  . PRO B 1 120 ? -49.047 18.522  -19.162 1.00 45.22  ? 124 PRO B CD  1 
ATOM   2235 N N   . LYS B 1 121 ? -52.357 19.349  -16.020 1.00 49.93  ? 125 LYS B N   1 
ATOM   2236 C CA  . LYS B 1 121 ? -52.713 20.395  -15.041 1.00 49.76  ? 125 LYS B CA  1 
ATOM   2237 C C   . LYS B 1 121 ? -51.467 20.885  -14.307 1.00 52.70  ? 125 LYS B C   1 
ATOM   2238 O O   . LYS B 1 121 ? -51.293 22.082  -14.181 1.00 47.61  ? 125 LYS B O   1 
ATOM   2239 C CB  . LYS B 1 121 ? -53.740 19.862  -14.053 1.00 56.44  ? 125 LYS B CB  1 
ATOM   2240 C CG  . LYS B 1 121 ? -54.152 20.907  -13.027 1.00 59.52  ? 125 LYS B CG  1 
ATOM   2241 C CD  . LYS B 1 121 ? -55.214 20.427  -12.122 1.00 60.98  ? 125 LYS B CD  1 
ATOM   2242 C CE  . LYS B 1 121 ? -55.741 21.548  -11.263 1.00 65.71  ? 125 LYS B CE  1 
ATOM   2243 N NZ  . LYS B 1 121 ? -56.444 20.994  -10.092 1.00 63.55  ? 125 LYS B NZ  1 
ATOM   2244 N N   . SER B 1 122 ? -50.619 19.988  -13.838 1.00 44.70  ? 126 SER B N   1 
ATOM   2245 C CA  . SER B 1 122 ? -49.370 20.364  -13.154 1.00 43.59  ? 126 SER B CA  1 
ATOM   2246 C C   . SER B 1 122 ? -48.315 19.299  -13.454 1.00 44.70  ? 126 SER B C   1 
ATOM   2247 O O   . SER B 1 122 ? -48.678 18.142  -13.686 1.00 42.57  ? 126 SER B O   1 
ATOM   2248 C CB  . SER B 1 122 ? -49.621 20.558  -11.655 1.00 45.99  ? 126 SER B CB  1 
ATOM   2249 O OG  . SER B 1 122 ? -49.775 19.321  -10.936 1.00 50.01  ? 126 SER B OG  1 
ATOM   2250 N N   . LEU B 1 123 ? -47.049 19.657  -13.347 1.00 41.74  ? 127 LEU B N   1 
ATOM   2251 C CA  . LEU B 1 123 ? -45.922 18.740  -13.572 1.00 44.91  ? 127 LEU B CA  1 
ATOM   2252 C C   . LEU B 1 123 ? -44.898 19.010  -12.487 1.00 50.59  ? 127 LEU B C   1 
ATOM   2253 O O   . LEU B 1 123 ? -44.628 20.182  -12.283 1.00 46.47  ? 127 LEU B O   1 
ATOM   2254 C CB  . LEU B 1 123 ? -45.410 19.041  -14.981 1.00 41.37  ? 127 LEU B CB  1 
ATOM   2255 C CG  . LEU B 1 123 ? -44.488 18.026  -15.621 1.00 44.12  ? 127 LEU B CG  1 
ATOM   2256 C CD1 . LEU B 1 123 ? -44.950 16.581  -15.404 1.00 46.48  ? 127 LEU B CD1 1 
ATOM   2257 C CD2 . LEU B 1 123 ? -44.419 18.340  -17.100 1.00 45.11  ? 127 LEU B CD2 1 
ATOM   2258 N N   . ALA B 1 124 ? -44.402 17.975  -11.802 1.00 41.86  ? 128 ALA B N   1 
ATOM   2259 C CA  . ALA B 1 124 ? -43.332 18.074  -10.780 1.00 39.60  ? 128 ALA B CA  1 
ATOM   2260 C C   . ALA B 1 124 ? -42.470 16.822  -10.813 1.00 45.23  ? 128 ALA B C   1 
ATOM   2261 O O   . ALA B 1 124 ? -42.889 15.850  -11.420 1.00 43.77  ? 128 ALA B O   1 
ATOM   2262 C CB  . ALA B 1 124 ? -43.922 18.287  -9.417  1.00 42.29  ? 128 ALA B CB  1 
ATOM   2263 N N   . ILE B 1 125 ? -41.295 16.888  -10.202 1.00 37.50  ? 129 ILE B N   1 
ATOM   2264 C CA  . ILE B 1 125 ? -40.348 15.778  -10.056 1.00 40.04  ? 129 ILE B CA  1 
ATOM   2265 C C   . ILE B 1 125 ? -40.202 15.500  -8.569  1.00 46.45  ? 129 ILE B C   1 
ATOM   2266 O O   . ILE B 1 125 ? -40.133 16.501  -7.742  1.00 40.91  ? 129 ILE B O   1 
ATOM   2267 C CB  . ILE B 1 125 ? -39.011 16.143  -10.719 1.00 44.09  ? 129 ILE B CB  1 
ATOM   2268 C CG1 . ILE B 1 125 ? -39.227 16.422  -12.213 1.00 50.90  ? 129 ILE B CG1 1 
ATOM   2269 C CG2 . ILE B 1 125 ? -37.952 15.087  -10.447 1.00 44.26  ? 129 ILE B CG2 1 
ATOM   2270 C CD1 . ILE B 1 125 ? -37.984 16.912  -12.940 1.00 51.77  ? 129 ILE B CD1 1 
ATOM   2271 N N   . CYS B 1 126 ? -40.122 14.204  -8.258  1.00 40.82  ? 130 CYS B N   1 
ATOM   2272 C CA  . CYS B 1 126 ? -39.630 13.656  -6.980  1.00 35.97  ? 130 CYS B CA  1 
ATOM   2273 C C   . CYS B 1 126 ? -38.484 12.704  -7.252  1.00 38.96  ? 130 CYS B C   1 
ATOM   2274 O O   . CYS B 1 126 ? -38.685 11.670  -7.934  1.00 38.02  ? 130 CYS B O   1 
ATOM   2275 C CB  . CYS B 1 126 ? -40.760 12.959  -6.237  1.00 41.23  ? 130 CYS B CB  1 
ATOM   2276 S SG  . CYS B 1 126 ? -40.228 12.233  -4.675  1.00 39.34  ? 130 CYS B SG  1 
ATOM   2277 N N   . THR B 1 127 ? -37.316 12.990  -6.700  1.00 35.12  ? 131 THR B N   1 
ATOM   2278 C CA  . THR B 1 127 ? -36.136 12.127  -6.850  1.00 37.27  ? 131 THR B CA  1 
ATOM   2279 C C   . THR B 1 127 ? -35.767 11.608  -5.463  1.00 40.79  ? 131 THR B C   1 
ATOM   2280 O O   . THR B 1 127 ? -35.923 12.338  -4.501  1.00 44.60  ? 131 THR B O   1 
ATOM   2281 C CB  . THR B 1 127 ? -35.021 12.857  -7.597  1.00 44.18  ? 131 THR B CB  1 
ATOM   2282 O OG1 . THR B 1 127 ? -33.986 11.901  -7.851  1.00 48.41  ? 131 THR B OG1 1 
ATOM   2283 C CG2 . THR B 1 127 ? -34.443 14.008  -6.797  1.00 42.33  ? 131 THR B CG2 1 
ATOM   2284 N N   . LEU B 1 128 ? -35.336 10.363  -5.359  1.00 42.35  ? 132 LEU B N   1 
ATOM   2285 C CA  . LEU B 1 128 ? -34.829 9.817   -4.077  1.00 43.77  ? 132 LEU B CA  1 
ATOM   2286 C C   . LEU B 1 128 ? -33.483 10.479  -3.798  1.00 38.76  ? 132 LEU B C   1 
ATOM   2287 O O   . LEU B 1 128 ? -33.246 10.816  -2.645  1.00 43.50  ? 132 LEU B O   1 
ATOM   2288 C CB  . LEU B 1 128 ? -34.646 8.294   -4.162  1.00 42.14  ? 132 LEU B CB  1 
ATOM   2289 C CG  . LEU B 1 128 ? -34.161 7.589   -2.894  1.00 44.45  ? 132 LEU B CG  1 
ATOM   2290 C CD1 . LEU B 1 128 ? -35.107 7.826   -1.729  1.00 46.98  ? 132 LEU B CD1 1 
ATOM   2291 C CD2 . LEU B 1 128 ? -33.984 6.103   -3.139  1.00 49.00  ? 132 LEU B CD2 1 
ATOM   2292 N N   . LEU B 1 129 ? -32.590 10.430  -4.776  1.00 36.22  ? 133 LEU B N   1 
ATOM   2293 C CA  . LEU B 1 129 ? -31.195 10.905  -4.638  1.00 40.84  ? 133 LEU B CA  1 
ATOM   2294 C C   . LEU B 1 129 ? -30.966 12.122  -5.553  1.00 47.00  ? 133 LEU B C   1 
ATOM   2295 O O   . LEU B 1 129 ? -31.486 12.157  -6.715  1.00 41.23  ? 133 LEU B O   1 
ATOM   2296 C CB  . LEU B 1 129 ? -30.196 9.809   -4.982  1.00 38.56  ? 133 LEU B CB  1 
ATOM   2297 C CG  . LEU B 1 129 ? -30.251 8.513   -4.196  1.00 40.90  ? 133 LEU B CG  1 
ATOM   2298 C CD1 . LEU B 1 129 ? -29.170 7.571   -4.693  1.00 45.39  ? 133 LEU B CD1 1 
ATOM   2299 C CD2 . LEU B 1 129 ? -30.100 8.730   -2.706  1.00 46.06  ? 133 LEU B CD2 1 
ATOM   2300 N N   . ASP B 1 130 ? -30.136 13.060  -5.090  1.00 43.89  ? 134 ASP B N   1 
ATOM   2301 C CA  . ASP B 1 130 ? -29.748 14.268  -5.867  1.00 46.02  ? 134 ASP B CA  1 
ATOM   2302 C C   . ASP B 1 130 ? -28.244 14.473  -5.632  1.00 40.95  ? 134 ASP B C   1 
ATOM   2303 O O   . ASP B 1 130 ? -27.815 14.407  -4.476  1.00 42.72  ? 134 ASP B O   1 
ATOM   2304 C CB  . ASP B 1 130 ? -30.712 15.413  -5.530  1.00 42.93  ? 134 ASP B CB  1 
ATOM   2305 C CG  . ASP B 1 130 ? -30.130 16.826  -5.600  1.00 62.47  ? 134 ASP B CG  1 
ATOM   2306 O OD1 . ASP B 1 130 ? -29.672 17.228  -6.684  1.00 54.41  ? 134 ASP B OD1 1 
ATOM   2307 O OD2 . ASP B 1 130 ? -30.148 17.539  -4.557  1.00 84.09  ? 134 ASP B OD2 1 
ATOM   2308 N N   . LYS B 1 131 ? -27.473 14.592  -6.711  1.00 41.45  ? 135 LYS B N   1 
ATOM   2309 C CA  . LYS B 1 131 ? -26.021 14.909  -6.696  1.00 44.28  ? 135 LYS B CA  1 
ATOM   2310 C C   . LYS B 1 131 ? -25.831 16.320  -7.238  1.00 41.97  ? 135 LYS B C   1 
ATOM   2311 O O   . LYS B 1 131 ? -25.554 16.469  -8.425  1.00 43.25  ? 135 LYS B O   1 
ATOM   2312 C CB  . LYS B 1 131 ? -25.233 13.944  -7.581  1.00 44.75  ? 135 LYS B CB  1 
ATOM   2313 C CG  . LYS B 1 131 ? -24.965 12.594  -6.960  1.00 45.03  ? 135 LYS B CG  1 
ATOM   2314 C CD  . LYS B 1 131 ? -24.480 11.592  -7.970  1.00 46.91  ? 135 LYS B CD  1 
ATOM   2315 C CE  . LYS B 1 131 ? -23.918 10.336  -7.355  1.00 50.93  ? 135 LYS B CE  1 
ATOM   2316 N NZ  . LYS B 1 131 ? -23.054 9.643   -8.330  1.00 49.18  ? 135 LYS B NZ  1 
ATOM   2317 N N   . PRO B 1 132 ? -26.074 17.384  -6.441  1.00 40.95  ? 136 PRO B N   1 
ATOM   2318 C CA  . PRO B 1 132 ? -26.043 18.751  -6.983  1.00 43.98  ? 136 PRO B CA  1 
ATOM   2319 C C   . PRO B 1 132 ? -24.649 19.173  -7.508  1.00 37.38  ? 136 PRO B C   1 
ATOM   2320 O O   . PRO B 1 132 ? -24.628 19.990  -8.381  1.00 42.29  ? 136 PRO B O   1 
ATOM   2321 C CB  . PRO B 1 132 ? -26.592 19.612  -5.834  1.00 45.57  ? 136 PRO B CB  1 
ATOM   2322 C CG  . PRO B 1 132 ? -26.317 18.787  -4.580  1.00 47.70  ? 136 PRO B CG  1 
ATOM   2323 C CD  . PRO B 1 132 ? -26.468 17.333  -5.025  1.00 47.31  ? 136 PRO B CD  1 
ATOM   2324 N N   . SER B 1 133 ? -23.577 18.505  -7.098  1.00 38.52  ? 137 SER B N   1 
ATOM   2325 C CA  . SER B 1 133 ? -22.214 18.663  -7.665  1.00 44.08  ? 137 SER B CA  1 
ATOM   2326 C C   . SER B 1 133 ? -22.173 18.286  -9.149  1.00 51.87  ? 137 SER B C   1 
ATOM   2327 O O   . SER B 1 133 ? -21.206 18.701  -9.755  1.00 43.07  ? 137 SER B O   1 
ATOM   2328 C CB  . SER B 1 133 ? -21.153 17.932  -6.855  1.00 46.81  ? 137 SER B CB  1 
ATOM   2329 O OG  . SER B 1 133 ? -21.253 16.512  -6.933  1.00 48.65  ? 137 SER B OG  1 
ATOM   2330 N N   . ARG B 1 134 ? -23.199 17.649  -9.745  1.00 50.98  ? 138 ARG B N   1 
ATOM   2331 C CA  . ARG B 1 134 ? -23.088 17.028  -11.106 1.00 48.48  ? 138 ARG B CA  1 
ATOM   2332 C C   . ARG B 1 134 ? -24.008 17.776  -12.084 1.00 48.67  ? 138 ARG B C   1 
ATOM   2333 O O   . ARG B 1 134 ? -23.999 17.492  -13.291 1.00 53.44  ? 138 ARG B O   1 
ATOM   2334 C CB  . ARG B 1 134 ? -23.281 15.504  -10.994 1.00 48.99  ? 138 ARG B CB  1 
ATOM   2335 C CG  . ARG B 1 134 ? -21.936 14.792  -11.094 1.00 59.73  ? 138 ARG B CG  1 
ATOM   2336 C CD  . ARG B 1 134 ? -21.737 13.308  -10.847 1.00 75.69  ? 138 ARG B CD  1 
ATOM   2337 N NE  . ARG B 1 134 ? -22.248 12.233  -11.720 1.00 70.54  ? 138 ARG B NE  1 
ATOM   2338 C CZ  . ARG B 1 134 ? -22.445 12.326  -13.011 1.00 64.39  ? 138 ARG B CZ  1 
ATOM   2339 N NH1 . ARG B 1 134 ? -22.137 13.437  -13.644 1.00 74.53  ? 138 ARG B NH1 1 
ATOM   2340 N NH2 . ARG B 1 134 ? -22.939 11.301  -13.674 1.00 74.04  ? 138 ARG B NH2 1 
ATOM   2341 N N   . ARG B 1 135 ? -24.696 18.800  -11.616 1.00 44.92  ? 139 ARG B N   1 
ATOM   2342 C CA  . ARG B 1 135 ? -25.768 19.494  -12.376 1.00 52.15  ? 139 ARG B CA  1 
ATOM   2343 C C   . ARG B 1 135 ? -25.101 20.180  -13.567 1.00 58.02  ? 139 ARG B C   1 
ATOM   2344 O O   . ARG B 1 135 ? -24.020 20.732  -13.390 1.00 62.43  ? 139 ARG B O   1 
ATOM   2345 C CB  . ARG B 1 135 ? -26.523 20.420  -11.412 1.00 53.67  ? 139 ARG B CB  1 
ATOM   2346 C CG  . ARG B 1 135 ? -27.918 20.860  -11.836 1.00 62.76  ? 139 ARG B CG  1 
ATOM   2347 C CD  . ARG B 1 135 ? -29.009 19.801  -11.941 1.00 60.31  ? 139 ARG B CD  1 
ATOM   2348 N NE  . ARG B 1 135 ? -28.697 18.679  -11.097 1.00 71.23  ? 139 ARG B NE  1 
ATOM   2349 C CZ  . ARG B 1 135 ? -29.218 18.410  -9.907  1.00 52.93  ? 139 ARG B CZ  1 
ATOM   2350 N NH1 . ARG B 1 135 ? -28.770 17.354  -9.270  1.00 53.73  ? 139 ARG B NH1 1 
ATOM   2351 N NH2 . ARG B 1 135 ? -30.157 19.152  -9.366  1.00 61.44  ? 139 ARG B NH2 1 
ATOM   2352 N N   . GLU B 1 136 ? -25.663 20.034  -14.759 1.00 56.25  ? 140 GLU B N   1 
ATOM   2353 C CA  . GLU B 1 136 ? -25.146 20.658  -16.001 1.00 57.34  ? 140 GLU B CA  1 
ATOM   2354 C C   . GLU B 1 136 ? -26.247 21.499  -16.624 1.00 58.13  ? 140 GLU B C   1 
ATOM   2355 O O   . GLU B 1 136 ? -25.979 22.115  -17.632 1.00 72.27  ? 140 GLU B O   1 
ATOM   2356 C CB  . GLU B 1 136 ? -24.734 19.603  -17.021 1.00 57.11  ? 140 GLU B CB  1 
ATOM   2357 C CG  . GLU B 1 136 ? -23.628 18.686  -16.562 1.00 55.37  ? 140 GLU B CG  1 
ATOM   2358 C CD  . GLU B 1 136 ? -23.229 17.697  -17.635 1.00 63.05  ? 140 GLU B CD  1 
ATOM   2359 O OE1 . GLU B 1 136 ? -22.222 17.000  -17.459 1.00 68.18  ? 140 GLU B OE1 1 
ATOM   2360 O OE2 . GLU B 1 136 ? -23.936 17.628  -18.648 1.00 72.55  ? 140 GLU B OE2 1 
ATOM   2361 N N   . VAL B 1 137 ? -27.447 21.480  -16.050 1.00 59.81  ? 141 VAL B N   1 
ATOM   2362 C CA  . VAL B 1 137 ? -28.695 22.062  -16.632 1.00 60.98  ? 141 VAL B CA  1 
ATOM   2363 C C   . VAL B 1 137 ? -29.599 22.288  -15.433 1.00 60.98  ? 141 VAL B C   1 
ATOM   2364 O O   . VAL B 1 137 ? -29.571 21.412  -14.555 1.00 64.63  ? 141 VAL B O   1 
ATOM   2365 C CB  . VAL B 1 137 ? -29.335 21.116  -17.673 1.00 73.45  ? 141 VAL B CB  1 
ATOM   2366 C CG1 . VAL B 1 137 ? -30.856 21.123  -17.625 1.00 77.04  ? 141 VAL B CG1 1 
ATOM   2367 C CG2 . VAL B 1 137 ? -28.842 21.396  -19.088 1.00 75.16  ? 141 VAL B CG2 1 
ATOM   2368 N N   . ASN B 1 138 ? -30.345 23.387  -15.391 1.00 65.04  ? 142 ASN B N   1 
ATOM   2369 C CA  . ASN B 1 138 ? -31.040 23.846  -14.162 1.00 68.92  ? 142 ASN B CA  1 
ATOM   2370 C C   . ASN B 1 138 ? -32.505 23.454  -14.276 1.00 70.44  ? 142 ASN B C   1 
ATOM   2371 O O   . ASN B 1 138 ? -33.324 24.293  -14.676 1.00 88.36  ? 142 ASN B O   1 
ATOM   2372 C CB  . ASN B 1 138 ? -30.820 25.333  -13.878 1.00 72.22  ? 142 ASN B CB  1 
ATOM   2373 C CG  . ASN B 1 138 ? -29.422 25.597  -13.355 1.00 83.61  ? 142 ASN B CG  1 
ATOM   2374 O OD1 . ASN B 1 138 ? -28.868 24.815  -12.579 1.00 94.49  ? 142 ASN B OD1 1 
ATOM   2375 N ND2 . ASN B 1 138 ? -28.820 26.684  -13.798 1.00 89.35  ? 142 ASN B ND2 1 
ATOM   2376 N N   . VAL B 1 139 ? -32.793 22.222  -13.880 1.00 67.88  ? 143 VAL B N   1 
ATOM   2377 C CA  . VAL B 1 139 ? -34.148 21.603  -13.939 1.00 63.88  ? 143 VAL B CA  1 
ATOM   2378 C C   . VAL B 1 139 ? -34.768 21.752  -12.554 1.00 55.98  ? 143 VAL B C   1 
ATOM   2379 O O   . VAL B 1 139 ? -34.120 21.487  -11.555 1.00 60.20  ? 143 VAL B O   1 
ATOM   2380 C CB  . VAL B 1 139 ? -34.053 20.137  -14.421 1.00 63.18  ? 143 VAL B CB  1 
ATOM   2381 C CG1 . VAL B 1 139 ? -33.111 19.322  -13.559 1.00 59.49  ? 143 VAL B CG1 1 
ATOM   2382 C CG2 . VAL B 1 139 ? -35.416 19.460  -14.529 1.00 68.36  ? 143 VAL B CG2 1 
ATOM   2383 N N   . PRO B 1 140 ? -36.044 22.180  -12.429 1.00 66.12  ? 144 PRO B N   1 
ATOM   2384 C CA  . PRO B 1 140 ? -36.642 22.382  -11.111 1.00 60.19  ? 144 PRO B CA  1 
ATOM   2385 C C   . PRO B 1 140 ? -37.086 21.013  -10.560 1.00 64.06  ? 144 PRO B C   1 
ATOM   2386 O O   . PRO B 1 140 ? -37.784 20.259  -11.253 1.00 67.30  ? 144 PRO B O   1 
ATOM   2387 C CB  . PRO B 1 140 ? -37.860 23.276  -11.400 1.00 65.43  ? 144 PRO B CB  1 
ATOM   2388 C CG  . PRO B 1 140 ? -38.260 22.949  -12.851 1.00 69.12  ? 144 PRO B CG  1 
ATOM   2389 C CD  . PRO B 1 140 ? -37.022 22.375  -13.524 1.00 64.82  ? 144 PRO B CD  1 
ATOM   2390 N N   . VAL B 1 141 ? -36.699 20.728  -9.328  1.00 57.15  ? 145 VAL B N   1 
ATOM   2391 C CA  . VAL B 1 141 ? -37.015 19.466  -8.611  1.00 56.96  ? 145 VAL B CA  1 
ATOM   2392 C C   . VAL B 1 141 ? -37.764 19.818  -7.338  1.00 53.91  ? 145 VAL B C   1 
ATOM   2393 O O   . VAL B 1 141 ? -37.137 20.370  -6.457  1.00 53.68  ? 145 VAL B O   1 
ATOM   2394 C CB  . VAL B 1 141 ? -35.728 18.678  -8.338  1.00 51.34  ? 145 VAL B CB  1 
ATOM   2395 C CG1 . VAL B 1 141 ? -36.003 17.396  -7.561  1.00 55.75  ? 145 VAL B CG1 1 
ATOM   2396 C CG2 . VAL B 1 141 ? -35.043 18.377  -9.654  1.00 60.03  ? 145 VAL B CG2 1 
ATOM   2397 N N   . GLU B 1 142 ? -39.039 19.453  -7.220  1.00 50.08  ? 146 GLU B N   1 
ATOM   2398 C CA  . GLU B 1 142 ? -39.912 19.890  -6.096  1.00 50.11  ? 146 GLU B CA  1 
ATOM   2399 C C   . GLU B 1 142 ? -39.675 19.023  -4.843  1.00 49.43  ? 146 GLU B C   1 
ATOM   2400 O O   . GLU B 1 142 ? -39.929 19.494  -3.764  1.00 47.20  ? 146 GLU B O   1 
ATOM   2401 C CB  . GLU B 1 142 ? -41.385 19.889  -6.541  1.00 55.87  ? 146 GLU B CB  1 
ATOM   2402 C CG  . GLU B 1 142 ? -41.728 20.884  -7.660  1.00 59.00  ? 146 GLU B CG  1 
ATOM   2403 C CD  . GLU B 1 142 ? -41.306 20.624  -9.116  1.00 60.60  ? 146 GLU B CD  1 
ATOM   2404 O OE1 . GLU B 1 142 ? -41.733 21.435  -9.960  1.00 61.32  ? 146 GLU B OE1 1 
ATOM   2405 O OE2 . GLU B 1 142 ? -40.542 19.639  -9.438  1.00 49.88  ? 146 GLU B OE2 1 
ATOM   2406 N N   . PHE B 1 143 ? -39.221 17.774  -4.948  1.00 42.65  ? 147 PHE B N   1 
ATOM   2407 C CA  . PHE B 1 143 ? -39.129 16.872  -3.772  1.00 39.56  ? 147 PHE B CA  1 
ATOM   2408 C C   . PHE B 1 143 ? -37.884 16.025  -3.917  1.00 42.18  ? 147 PHE B C   1 
ATOM   2409 O O   . PHE B 1 143 ? -37.669 15.365  -4.978  1.00 45.25  ? 147 PHE B O   1 
ATOM   2410 C CB  . PHE B 1 143 ? -40.303 15.886  -3.674  1.00 41.41  ? 147 PHE B CB  1 
ATOM   2411 C CG  . PHE B 1 143 ? -41.653 16.526  -3.632  1.00 41.03  ? 147 PHE B CG  1 
ATOM   2412 C CD1 . PHE B 1 143 ? -42.210 16.912  -2.426  1.00 44.80  ? 147 PHE B CD1 1 
ATOM   2413 C CD2 . PHE B 1 143 ? -42.373 16.752  -4.789  1.00 37.18  ? 147 PHE B CD2 1 
ATOM   2414 C CE1 . PHE B 1 143 ? -43.453 17.520  -2.392  1.00 39.17  ? 147 PHE B CE1 1 
ATOM   2415 C CE2 . PHE B 1 143 ? -43.602 17.393  -4.750  1.00 34.71  ? 147 PHE B CE2 1 
ATOM   2416 C CZ  . PHE B 1 143 ? -44.139 17.772  -3.554  1.00 36.37  ? 147 PHE B CZ  1 
ATOM   2417 N N   . ILE B 1 144 ? -37.092 16.003  -2.868  1.00 37.02  ? 148 ILE B N   1 
ATOM   2418 C CA  . ILE B 1 144 ? -35.786 15.341  -2.889  1.00 34.64  ? 148 ILE B CA  1 
ATOM   2419 C C   . ILE B 1 144 ? -35.653 14.554  -1.608  1.00 40.20  ? 148 ILE B C   1 
ATOM   2420 O O   . ILE B 1 144 ? -35.758 15.177  -0.539  1.00 38.92  ? 148 ILE B O   1 
ATOM   2421 C CB  . ILE B 1 144 ? -34.663 16.383  -3.022  1.00 36.60  ? 148 ILE B CB  1 
ATOM   2422 C CG1 . ILE B 1 144 ? -34.694 17.122  -4.359  1.00 37.95  ? 148 ILE B CG1 1 
ATOM   2423 C CG2 . ILE B 1 144 ? -33.327 15.718  -2.814  1.00 38.93  ? 148 ILE B CG2 1 
ATOM   2424 C CD1 . ILE B 1 144 ? -33.704 18.353  -4.426  1.00 40.54  ? 148 ILE B CD1 1 
ATOM   2425 N N   . GLY B 1 145 ? -35.347 13.259  -1.706  1.00 40.78  ? 149 GLY B N   1 
ATOM   2426 C CA  . GLY B 1 145 ? -35.076 12.436  -0.514  1.00 40.87  ? 149 GLY B CA  1 
ATOM   2427 C C   . GLY B 1 145 ? -33.758 12.817  0.164   1.00 43.67  ? 149 GLY B C   1 
ATOM   2428 O O   . GLY B 1 145 ? -33.751 13.143  1.352   1.00 42.49  ? 149 GLY B O   1 
ATOM   2429 N N   . PHE B 1 146 ? -32.669 12.792  -0.585  1.00 41.01  ? 150 PHE B N   1 
ATOM   2430 C CA  . PHE B 1 146 ? -31.293 12.972  -0.075  1.00 42.44  ? 150 PHE B CA  1 
ATOM   2431 C C   . PHE B 1 146 ? -30.431 13.669  -1.134  1.00 46.97  ? 150 PHE B C   1 
ATOM   2432 O O   . PHE B 1 146 ? -30.335 13.175  -2.283  1.00 37.37  ? 150 PHE B O   1 
ATOM   2433 C CB  . PHE B 1 146 ? -30.611 11.649  0.233   1.00 45.64  ? 150 PHE B CB  1 
ATOM   2434 C CG  . PHE B 1 146 ? -31.350 10.766  1.197   1.00 56.75  ? 150 PHE B CG  1 
ATOM   2435 C CD1 . PHE B 1 146 ? -31.097 10.835  2.554   1.00 51.91  ? 150 PHE B CD1 1 
ATOM   2436 C CD2 . PHE B 1 146 ? -32.246 9.816   0.733   1.00 59.84  ? 150 PHE B CD2 1 
ATOM   2437 C CE1 . PHE B 1 146 ? -31.751 9.989   3.430   1.00 57.49  ? 150 PHE B CE1 1 
ATOM   2438 C CE2 . PHE B 1 146 ? -32.897 8.970   1.613   1.00 58.44  ? 150 PHE B CE2 1 
ATOM   2439 C CZ  . PHE B 1 146 ? -32.649 9.062   2.963   1.00 59.67  ? 150 PHE B CZ  1 
ATOM   2440 N N   . SER B 1 147 ? -29.788 14.768  -0.739  1.00 40.35  ? 151 SER B N   1 
ATOM   2441 C CA  . SER B 1 147 ? -28.699 15.370  -1.535  1.00 36.16  ? 151 SER B CA  1 
ATOM   2442 C C   . SER B 1 147 ? -27.437 14.681  -1.064  1.00 34.46  ? 151 SER B C   1 
ATOM   2443 O O   . SER B 1 147 ? -27.215 14.547  0.164   1.00 38.56  ? 151 SER B O   1 
ATOM   2444 C CB  . SER B 1 147 ? -28.703 16.878  -1.469  1.00 41.70  ? 151 SER B CB  1 
ATOM   2445 O OG  . SER B 1 147 ? -30.014 17.412  -1.650  1.00 37.60  ? 151 SER B OG  1 
ATOM   2446 N N   . ILE B 1 148 ? -26.681 14.130  -1.998  1.00 35.85  ? 152 ILE B N   1 
ATOM   2447 C CA  . ILE B 1 148 ? -25.524 13.268  -1.650  1.00 35.63  ? 152 ILE B CA  1 
ATOM   2448 C C   . ILE B 1 148 ? -24.318 13.786  -2.393  1.00 36.67  ? 152 ILE B C   1 
ATOM   2449 O O   . ILE B 1 148 ? -24.448 14.407  -3.448  1.00 38.00  ? 152 ILE B O   1 
ATOM   2450 C CB  . ILE B 1 148 ? -25.803 11.793  -2.031  1.00 40.50  ? 152 ILE B CB  1 
ATOM   2451 C CG1 . ILE B 1 148 ? -26.137 11.616  -3.511  1.00 41.75  ? 152 ILE B CG1 1 
ATOM   2452 C CG2 . ILE B 1 148 ? -26.910 11.262  -1.145  1.00 36.79  ? 152 ILE B CG2 1 
ATOM   2453 C CD1 . ILE B 1 148 ? -25.953 10.195  -3.995  1.00 45.13  ? 152 ILE B CD1 1 
ATOM   2454 N N   . PRO B 1 149 ? -23.129 13.403  -1.918  1.00 38.36  ? 153 PRO B N   1 
ATOM   2455 C CA  . PRO B 1 149 ? -21.912 13.601  -2.677  1.00 43.47  ? 153 PRO B CA  1 
ATOM   2456 C C   . PRO B 1 149 ? -21.903 12.731  -3.935  1.00 51.61  ? 153 PRO B C   1 
ATOM   2457 O O   . PRO B 1 149 ? -22.782 11.894  -4.122  1.00 52.14  ? 153 PRO B O   1 
ATOM   2458 C CB  . PRO B 1 149 ? -20.811 13.252  -1.664  1.00 46.18  ? 153 PRO B CB  1 
ATOM   2459 C CG  . PRO B 1 149 ? -21.470 12.352  -0.650  1.00 42.91  ? 153 PRO B CG  1 
ATOM   2460 C CD  . PRO B 1 149 ? -22.929 12.712  -0.645  1.00 42.01  ? 153 PRO B CD  1 
ATOM   2461 N N   . ASP B 1 150 ? -20.933 12.983  -4.809  1.00 46.40  ? 154 ASP B N   1 
ATOM   2462 C CA  . ASP B 1 150 ? -20.798 12.295  -6.110  1.00 52.94  ? 154 ASP B CA  1 
ATOM   2463 C C   . ASP B 1 150 ? -20.192 10.901  -5.882  1.00 54.73  ? 154 ASP B C   1 
ATOM   2464 O O   . ASP B 1 150 ? -19.190 10.584  -6.520  1.00 63.44  ? 154 ASP B O   1 
ATOM   2465 C CB  . ASP B 1 150 ? -19.992 13.134  -7.094  1.00 53.33  ? 154 ASP B CB  1 
ATOM   2466 C CG  . ASP B 1 150 ? -19.986 12.545  -8.481  1.00 56.26  ? 154 ASP B CG  1 
ATOM   2467 O OD1 . ASP B 1 150 ? -20.897 11.697  -8.795  1.00 55.51  ? 154 ASP B OD1 1 
ATOM   2468 O OD2 . ASP B 1 150 ? -19.102 12.930  -9.239  1.00 57.59  ? 154 ASP B OD2 1 
ATOM   2469 N N   . GLU B 1 151 ? -20.798 10.085  -5.018  1.00 55.87  ? 155 GLU B N   1 
ATOM   2470 C CA  . GLU B 1 151 ? -20.352 8.680   -4.767  1.00 54.67  ? 155 GLU B CA  1 
ATOM   2471 C C   . GLU B 1 151 ? -20.887 7.771   -5.887  1.00 49.79  ? 155 GLU B C   1 
ATOM   2472 O O   . GLU B 1 151 ? -21.818 8.164   -6.659  1.00 46.77  ? 155 GLU B O   1 
ATOM   2473 C CB  . GLU B 1 151 ? -20.832 8.152   -3.414  1.00 60.02  ? 155 GLU B CB  1 
ATOM   2474 C CG  . GLU B 1 151 ? -20.534 9.051   -2.227  1.00 63.47  ? 155 GLU B CG  1 
ATOM   2475 C CD  . GLU B 1 151 ? -19.083 9.077   -1.806  1.00 72.79  ? 155 GLU B CD  1 
ATOM   2476 O OE1 . GLU B 1 151 ? -18.712 9.968   -0.995  1.00 76.62  ? 155 GLU B OE1 1 
ATOM   2477 O OE2 . GLU B 1 151 ? -18.328 8.213   -2.298  1.00 75.09  ? 155 GLU B OE2 1 
ATOM   2478 N N   . PHE B 1 152 ? -20.270 6.613   -6.031  1.00 53.49  ? 156 PHE B N   1 
ATOM   2479 C CA  . PHE B 1 152 ? -20.657 5.573   -7.013  1.00 55.81  ? 156 PHE B CA  1 
ATOM   2480 C C   . PHE B 1 152 ? -21.765 4.766   -6.314  1.00 49.93  ? 156 PHE B C   1 
ATOM   2481 O O   . PHE B 1 152 ? -21.445 3.879   -5.479  1.00 48.98  ? 156 PHE B O   1 
ATOM   2482 C CB  . PHE B 1 152 ? -19.383 4.809   -7.395  1.00 62.66  ? 156 PHE B CB  1 
ATOM   2483 C CG  . PHE B 1 152 ? -19.463 3.777   -8.492  1.00 72.40  ? 156 PHE B CG  1 
ATOM   2484 C CD1 . PHE B 1 152 ? -20.676 3.271   -8.952  1.00 79.67  ? 156 PHE B CD1 1 
ATOM   2485 C CD2 . PHE B 1 152 ? -18.286 3.244   -9.013  1.00 83.87  ? 156 PHE B CD2 1 
ATOM   2486 C CE1 . PHE B 1 152 ? -20.708 2.284   -9.932  1.00 80.42  ? 156 PHE B CE1 1 
ATOM   2487 C CE2 . PHE B 1 152 ? -18.318 2.262   -9.995  1.00 88.26  ? 156 PHE B CE2 1 
ATOM   2488 C CZ  . PHE B 1 152 ? -19.532 1.785   -10.449 1.00 84.15  ? 156 PHE B CZ  1 
ATOM   2489 N N   . VAL B 1 153 ? -23.023 5.113   -6.578  1.00 47.43  ? 157 VAL B N   1 
ATOM   2490 C CA  . VAL B 1 153 ? -24.174 4.615   -5.764  1.00 51.11  ? 157 VAL B CA  1 
ATOM   2491 C C   . VAL B 1 153 ? -24.739 3.362   -6.420  1.00 47.43  ? 157 VAL B C   1 
ATOM   2492 O O   . VAL B 1 153 ? -24.773 3.312   -7.671  1.00 43.98  ? 157 VAL B O   1 
ATOM   2493 C CB  . VAL B 1 153 ? -25.264 5.668   -5.558  1.00 53.89  ? 157 VAL B CB  1 
ATOM   2494 C CG1 . VAL B 1 153 ? -24.774 6.729   -4.593  1.00 57.17  ? 157 VAL B CG1 1 
ATOM   2495 C CG2 . VAL B 1 153 ? -25.728 6.273   -6.865  1.00 61.51  ? 157 VAL B CG2 1 
ATOM   2496 N N   . VAL B 1 154 ? -25.123 2.389   -5.597  1.00 47.82  ? 158 VAL B N   1 
ATOM   2497 C CA  . VAL B 1 154 ? -25.876 1.192   -6.068  1.00 49.70  ? 158 VAL B CA  1 
ATOM   2498 C C   . VAL B 1 154 ? -26.984 0.882   -5.077  1.00 48.58  ? 158 VAL B C   1 
ATOM   2499 O O   . VAL B 1 154 ? -26.952 1.390   -3.915  1.00 45.24  ? 158 VAL B O   1 
ATOM   2500 C CB  . VAL B 1 154 ? -24.974 -0.040  -6.250  1.00 46.82  ? 158 VAL B CB  1 
ATOM   2501 C CG1 . VAL B 1 154 ? -23.994 0.163   -7.379  1.00 49.77  ? 158 VAL B CG1 1 
ATOM   2502 C CG2 . VAL B 1 154 ? -24.290 -0.443  -4.954  1.00 49.29  ? 158 VAL B CG2 1 
ATOM   2503 N N   . GLY B 1 155 ? -27.896 0.016   -5.522  1.00 48.12  ? 159 GLY B N   1 
ATOM   2504 C CA  . GLY B 1 155 ? -28.964 -0.547  -4.687  1.00 43.18  ? 159 GLY B CA  1 
ATOM   2505 C C   . GLY B 1 155 ? -30.251 0.198   -4.910  1.00 43.42  ? 159 GLY B C   1 
ATOM   2506 O O   . GLY B 1 155 ? -30.231 1.228   -5.610  1.00 40.47  ? 159 GLY B O   1 
ATOM   2507 N N   . TYR B 1 156 ? -31.352 -0.348  -4.382  1.00 38.99  ? 160 TYR B N   1 
ATOM   2508 C CA  . TYR B 1 156 ? -32.660 0.340   -4.339  1.00 39.71  ? 160 TYR B CA  1 
ATOM   2509 C C   . TYR B 1 156 ? -33.013 0.767   -5.783  1.00 41.45  ? 160 TYR B C   1 
ATOM   2510 O O   . TYR B 1 156 ? -33.496 1.894   -6.041  1.00 39.73  ? 160 TYR B O   1 
ATOM   2511 C CB  . TYR B 1 156 ? -32.568 1.423   -3.254  1.00 39.08  ? 160 TYR B CB  1 
ATOM   2512 C CG  . TYR B 1 156 ? -33.926 1.779   -2.748  1.00 40.54  ? 160 TYR B CG  1 
ATOM   2513 C CD1 . TYR B 1 156 ? -34.554 1.061   -1.736  1.00 40.86  ? 160 TYR B CD1 1 
ATOM   2514 C CD2 . TYR B 1 156 ? -34.604 2.812   -3.342  1.00 38.16  ? 160 TYR B CD2 1 
ATOM   2515 C CE1 . TYR B 1 156 ? -35.846 1.379   -1.341  1.00 42.90  ? 160 TYR B CE1 1 
ATOM   2516 C CE2 . TYR B 1 156 ? -35.881 3.147   -2.956  1.00 39.83  ? 160 TYR B CE2 1 
ATOM   2517 C CZ  . TYR B 1 156 ? -36.514 2.399   -1.984  1.00 38.17  ? 160 TYR B CZ  1 
ATOM   2518 O OH  . TYR B 1 156 ? -37.774 2.791   -1.670  1.00 39.72  ? 160 TYR B OH  1 
ATOM   2519 N N   . GLY B 1 157 ? -32.769 -0.154  -6.737  1.00 39.91  ? 161 GLY B N   1 
ATOM   2520 C CA  . GLY B 1 157 ? -33.172 -0.000  -8.151  1.00 39.14  ? 161 GLY B CA  1 
ATOM   2521 C C   . GLY B 1 157 ? -31.997 0.361   -9.059  1.00 43.37  ? 161 GLY B C   1 
ATOM   2522 O O   . GLY B 1 157 ? -32.112 0.171   -10.298 1.00 42.70  ? 161 GLY B O   1 
ATOM   2523 N N   . ILE B 1 158 ? -30.888 0.823   -8.479  1.00 39.33  ? 162 ILE B N   1 
ATOM   2524 C CA  . ILE B 1 158 ? -29.679 1.259   -9.231  1.00 41.60  ? 162 ILE B CA  1 
ATOM   2525 C C   . ILE B 1 158 ? -28.662 0.123   -9.315  1.00 43.52  ? 162 ILE B C   1 
ATOM   2526 O O   . ILE B 1 158 ? -28.294 -0.438  -8.272  1.00 40.60  ? 162 ILE B O   1 
ATOM   2527 C CB  . ILE B 1 158 ? -29.040 2.488   -8.567  1.00 42.65  ? 162 ILE B CB  1 
ATOM   2528 C CG1 . ILE B 1 158 ? -30.041 3.631   -8.423  1.00 48.88  ? 162 ILE B CG1 1 
ATOM   2529 C CG2 . ILE B 1 158 ? -27.801 2.884   -9.368  1.00 46.75  ? 162 ILE B CG2 1 
ATOM   2530 C CD1 . ILE B 1 158 ? -29.718 4.588   -7.305  1.00 56.57  ? 162 ILE B CD1 1 
ATOM   2531 N N   . ASP B 1 159 ? -28.138 -0.105  -10.515 1.00 43.14  ? 163 ASP B N   1 
ATOM   2532 C CA  . ASP B 1 159 ? -27.245 -1.231  -10.846 1.00 47.55  ? 163 ASP B CA  1 
ATOM   2533 C C   . ASP B 1 159 ? -25.784 -0.763  -10.939 1.00 52.13  ? 163 ASP B C   1 
ATOM   2534 O O   . ASP B 1 159 ? -25.555 0.396   -11.215 1.00 48.71  ? 163 ASP B O   1 
ATOM   2535 C CB  . ASP B 1 159 ? -27.688 -1.839  -12.172 1.00 50.99  ? 163 ASP B CB  1 
ATOM   2536 C CG  . ASP B 1 159 ? -27.331 -1.010  -13.404 1.00 55.97  ? 163 ASP B CG  1 
ATOM   2537 O OD1 . ASP B 1 159 ? -27.879 0.135   -13.559 1.00 52.45  ? 163 ASP B OD1 1 
ATOM   2538 O OD2 . ASP B 1 159 ? -26.514 -1.511  -14.188 1.00 61.12  ? 163 ASP B OD2 1 
ATOM   2539 N N   . TYR B 1 160 ? -24.843 -1.669  -10.717 1.00 51.72  ? 164 TYR B N   1 
ATOM   2540 C CA  . TYR B 1 160 ? -23.474 -1.628  -11.279 1.00 56.28  ? 164 TYR B CA  1 
ATOM   2541 C C   . TYR B 1 160 ? -23.326 -2.834  -12.214 1.00 56.97  ? 164 TYR B C   1 
ATOM   2542 O O   . TYR B 1 160 ? -23.328 -3.981  -11.704 1.00 60.35  ? 164 TYR B O   1 
ATOM   2543 C CB  . TYR B 1 160 ? -22.430 -1.686  -10.163 1.00 61.41  ? 164 TYR B CB  1 
ATOM   2544 C CG  . TYR B 1 160 ? -20.995 -1.794  -10.622 1.00 62.91  ? 164 TYR B CG  1 
ATOM   2545 C CD1 . TYR B 1 160 ? -20.539 -1.098  -11.732 1.00 66.61  ? 164 TYR B CD1 1 
ATOM   2546 C CD2 . TYR B 1 160 ? -20.073 -2.548  -9.913  1.00 69.57  ? 164 TYR B CD2 1 
ATOM   2547 C CE1 . TYR B 1 160 ? -19.214 -1.159  -12.142 1.00 65.73  ? 164 TYR B CE1 1 
ATOM   2548 C CE2 . TYR B 1 160 ? -18.741 -2.608  -10.300 1.00 73.39  ? 164 TYR B CE2 1 
ATOM   2549 C CZ  . TYR B 1 160 ? -18.316 -1.916  -11.421 1.00 67.35  ? 164 TYR B CZ  1 
ATOM   2550 O OH  . TYR B 1 160 ? -17.027 -1.976  -11.830 1.00 65.97  ? 164 TYR B OH  1 
ATOM   2551 N N   . ALA B 1 161 ? -23.225 -2.588  -13.517 1.00 62.71  ? 165 ALA B N   1 
ATOM   2552 C CA  . ALA B 1 161 ? -23.201 -3.653  -14.538 1.00 70.22  ? 165 ALA B CA  1 
ATOM   2553 C C   . ALA B 1 161 ? -24.280 -4.671  -14.157 1.00 70.56  ? 165 ALA B C   1 
ATOM   2554 O O   . ALA B 1 161 ? -23.918 -5.798  -13.771 1.00 63.94  ? 165 ALA B O   1 
ATOM   2555 C CB  . ALA B 1 161 ? -21.830 -4.279  -14.574 1.00 73.89  ? 165 ALA B CB  1 
ATOM   2556 N N   . GLN B 1 162 ? -25.548 -4.244  -14.112 1.00 69.82  ? 166 GLN B N   1 
ATOM   2557 C CA  . GLN B 1 162 ? -26.709 -5.174  -13.992 1.00 76.12  ? 166 GLN B CA  1 
ATOM   2558 C C   . GLN B 1 162 ? -26.834 -5.795  -12.582 1.00 78.40  ? 166 GLN B C   1 
ATOM   2559 O O   . GLN B 1 162 ? -27.912 -6.376  -12.287 1.00 81.63  ? 166 GLN B O   1 
ATOM   2560 C CB  . GLN B 1 162 ? -26.609 -6.255  -15.081 1.00 71.37  ? 166 GLN B CB  1 
ATOM   2561 C CG  . GLN B 1 162 ? -27.141 -5.786  -16.434 1.00 76.91  ? 166 GLN B CG  1 
ATOM   2562 C CD  . GLN B 1 162 ? -28.420 -4.971  -16.326 1.00 86.67  ? 166 GLN B CD  1 
ATOM   2563 O OE1 . GLN B 1 162 ? -29.512 -5.473  -15.994 1.00 98.23  ? 166 GLN B OE1 1 
ATOM   2564 N NE2 . GLN B 1 162 ? -28.288 -3.686  -16.611 1.00 64.21  ? 166 GLN B NE2 1 
ATOM   2565 N N   . ARG B 1 163 ? -25.831 -5.617  -11.715 1.00 62.11  ? 167 ARG B N   1 
ATOM   2566 C CA  . ARG B 1 163 ? -25.791 -6.175  -10.340 1.00 51.93  ? 167 ARG B CA  1 
ATOM   2567 C C   . ARG B 1 163 ? -26.389 -5.169  -9.332  1.00 51.58  ? 167 ARG B C   1 
ATOM   2568 O O   . ARG B 1 163 ? -26.366 -3.953  -9.639  1.00 48.40  ? 167 ARG B O   1 
ATOM   2569 C CB  . ARG B 1 163 ? -24.322 -6.504  -10.079 1.00 59.56  ? 167 ARG B CB  1 
ATOM   2570 C CG  . ARG B 1 163 ? -24.114 -7.782  -9.302  1.00 66.47  ? 167 ARG B CG  1 
ATOM   2571 C CD  . ARG B 1 163 ? -22.679 -8.261  -9.344  1.00 74.99  ? 167 ARG B CD  1 
ATOM   2572 N NE  . ARG B 1 163 ? -22.392 -8.911  -8.065  1.00 86.65  ? 167 ARG B NE  1 
ATOM   2573 C CZ  . ARG B 1 163 ? -21.187 -9.071  -7.518  1.00 89.60  ? 167 ARG B CZ  1 
ATOM   2574 N NH1 . ARG B 1 163 ? -20.094 -8.641  -8.126  1.00 89.28  ? 167 ARG B NH1 1 
ATOM   2575 N NH2 . ARG B 1 163 ? -21.083 -9.654  -6.338  1.00 94.51  ? 167 ARG B NH2 1 
ATOM   2576 N N   . TYR B 1 164 ? -26.946 -5.643  -8.201  1.00 45.34  ? 168 TYR B N   1 
ATOM   2577 C CA  . TYR B 1 164 ? -27.245 -4.890  -6.935  1.00 47.33  ? 168 TYR B CA  1 
ATOM   2578 C C   . TYR B 1 164 ? -28.556 -4.102  -6.958  1.00 41.18  ? 168 TYR B C   1 
ATOM   2579 O O   . TYR B 1 164 ? -28.860 -3.436  -5.971  1.00 39.15  ? 168 TYR B O   1 
ATOM   2580 C CB  . TYR B 1 164 ? -26.138 -3.905  -6.547  1.00 50.08  ? 168 TYR B CB  1 
ATOM   2581 C CG  . TYR B 1 164 ? -24.778 -4.545  -6.404  1.00 49.82  ? 168 TYR B CG  1 
ATOM   2582 C CD1 . TYR B 1 164 ? -24.570 -5.608  -5.530  1.00 48.29  ? 168 TYR B CD1 1 
ATOM   2583 C CD2 . TYR B 1 164 ? -23.704 -4.084  -7.147  1.00 53.16  ? 168 TYR B CD2 1 
ATOM   2584 C CE1 . TYR B 1 164 ? -23.322 -6.196  -5.397  1.00 55.43  ? 168 TYR B CE1 1 
ATOM   2585 C CE2 . TYR B 1 164 ? -22.451 -4.657  -7.019  1.00 55.21  ? 168 TYR B CE2 1 
ATOM   2586 C CZ  . TYR B 1 164 ? -22.266 -5.716  -6.151  1.00 56.29  ? 168 TYR B CZ  1 
ATOM   2587 O OH  . TYR B 1 164 ? -21.039 -6.273  -6.062  1.00 60.30  ? 168 TYR B OH  1 
ATOM   2588 N N   . ARG B 1 165 ? -29.363 -4.230  -7.998  1.00 42.83  ? 169 ARG B N   1 
ATOM   2589 C CA  . ARG B 1 165 ? -30.661 -3.511  -8.082  1.00 43.91  ? 169 ARG B CA  1 
ATOM   2590 C C   . ARG B 1 165 ? -31.589 -3.860  -6.911  1.00 41.40  ? 169 ARG B C   1 
ATOM   2591 O O   . ARG B 1 165 ? -32.364 -3.009  -6.512  1.00 38.44  ? 169 ARG B O   1 
ATOM   2592 C CB  . ARG B 1 165 ? -31.384 -3.879  -9.377  1.00 40.42  ? 169 ARG B CB  1 
ATOM   2593 C CG  . ARG B 1 165 ? -31.007 -3.013  -10.548 1.00 43.19  ? 169 ARG B CG  1 
ATOM   2594 C CD  . ARG B 1 165 ? -32.000 -3.120  -11.695 1.00 45.58  ? 169 ARG B CD  1 
ATOM   2595 N NE  . ARG B 1 165 ? -31.209 -2.944  -12.910 1.00 45.64  ? 169 ARG B NE  1 
ATOM   2596 C CZ  . ARG B 1 165 ? -31.018 -1.777  -13.526 1.00 49.54  ? 169 ARG B CZ  1 
ATOM   2597 N NH1 . ARG B 1 165 ? -31.595 -0.683  -13.058 1.00 42.31  ? 169 ARG B NH1 1 
ATOM   2598 N NH2 . ARG B 1 165 ? -30.287 -1.725  -14.623 1.00 49.78  ? 169 ARG B NH2 1 
ATOM   2599 N N   . HIS B 1 166 ? -31.492 -5.075  -6.376  1.00 38.70  ? 170 HIS B N   1 
ATOM   2600 C CA  . HIS B 1 166 ? -32.428 -5.649  -5.391  1.00 37.13  ? 170 HIS B CA  1 
ATOM   2601 C C   . HIS B 1 166 ? -31.960 -5.338  -3.961  1.00 42.98  ? 170 HIS B C   1 
ATOM   2602 O O   . HIS B 1 166 ? -32.629 -5.738  -3.004  1.00 45.10  ? 170 HIS B O   1 
ATOM   2603 C CB  . HIS B 1 166 ? -32.542 -7.157  -5.731  1.00 41.30  ? 170 HIS B CB  1 
ATOM   2604 C CG  . HIS B 1 166 ? -31.232 -7.867  -5.759  1.00 40.12  ? 170 HIS B CG  1 
ATOM   2605 N ND1 . HIS B 1 166 ? -30.589 -8.274  -4.598  1.00 44.63  ? 170 HIS B ND1 1 
ATOM   2606 C CD2 . HIS B 1 166 ? -30.424 -8.230  -6.790  1.00 42.92  ? 170 HIS B CD2 1 
ATOM   2607 C CE1 . HIS B 1 166 ? -29.432 -8.850  -4.924  1.00 42.44  ? 170 HIS B CE1 1 
ATOM   2608 N NE2 . HIS B 1 166 ? -29.334 -8.874  -6.259  1.00 42.37  ? 170 HIS B NE2 1 
ATOM   2609 N N   . LEU B 1 167 ? -30.799 -4.715  -3.775  1.00 43.23  ? 171 LEU B N   1 
ATOM   2610 C CA  . LEU B 1 167 ? -30.329 -4.331  -2.416  1.00 41.34  ? 171 LEU B CA  1 
ATOM   2611 C C   . LEU B 1 167 ? -31.378 -3.433  -1.784  1.00 42.11  ? 171 LEU B C   1 
ATOM   2612 O O   . LEU B 1 167 ? -31.912 -2.550  -2.462  1.00 42.59  ? 171 LEU B O   1 
ATOM   2613 C CB  . LEU B 1 167 ? -28.989 -3.594  -2.548  1.00 47.24  ? 171 LEU B CB  1 
ATOM   2614 C CG  . LEU B 1 167 ? -27.717 -4.392  -2.332  1.00 55.07  ? 171 LEU B CG  1 
ATOM   2615 C CD1 . LEU B 1 167 ? -27.842 -5.812  -2.792  1.00 57.96  ? 171 LEU B CD1 1 
ATOM   2616 C CD2 . LEU B 1 167 ? -26.526 -3.718  -2.979  1.00 51.77  ? 171 LEU B CD2 1 
ATOM   2617 N N   . PRO B 1 168 ? -31.729 -3.607  -0.483  1.00 38.63  ? 172 PRO B N   1 
ATOM   2618 C CA  . PRO B 1 168 ? -32.746 -2.768  0.152   1.00 40.97  ? 172 PRO B CA  1 
ATOM   2619 C C   . PRO B 1 168 ? -32.219 -1.455  0.763   1.00 37.99  ? 172 PRO B C   1 
ATOM   2620 O O   . PRO B 1 168 ? -32.948 -0.735  1.392   1.00 39.28  ? 172 PRO B O   1 
ATOM   2621 C CB  . PRO B 1 168 ? -33.303 -3.642  1.277   1.00 39.35  ? 172 PRO B CB  1 
ATOM   2622 C CG  . PRO B 1 168 ? -32.134 -4.515  1.636   1.00 41.29  ? 172 PRO B CG  1 
ATOM   2623 C CD  . PRO B 1 168 ? -31.285 -4.705  0.392   1.00 41.28  ? 172 PRO B CD  1 
ATOM   2624 N N   . TYR B 1 169 ? -30.950 -1.171  0.532   1.00 41.75  ? 173 TYR B N   1 
ATOM   2625 C CA  . TYR B 1 169 ? -30.242 0.014   1.052   1.00 41.32  ? 173 TYR B CA  1 
ATOM   2626 C C   . TYR B 1 169 ? -29.514 0.643   -0.142  1.00 45.15  ? 173 TYR B C   1 
ATOM   2627 O O   . TYR B 1 169 ? -29.397 -0.001  -1.198  1.00 39.89  ? 173 TYR B O   1 
ATOM   2628 C CB  . TYR B 1 169 ? -29.322 -0.389  2.215   1.00 41.70  ? 173 TYR B CB  1 
ATOM   2629 C CG  . TYR B 1 169 ? -28.212 -1.331  1.843   1.00 43.87  ? 173 TYR B CG  1 
ATOM   2630 C CD1 . TYR B 1 169 ? -27.046 -0.873  1.281   1.00 45.06  ? 173 TYR B CD1 1 
ATOM   2631 C CD2 . TYR B 1 169 ? -28.348 -2.699  2.003   1.00 49.20  ? 173 TYR B CD2 1 
ATOM   2632 C CE1 . TYR B 1 169 ? -26.016 -1.731  0.932   1.00 44.15  ? 173 TYR B CE1 1 
ATOM   2633 C CE2 . TYR B 1 169 ? -27.339 -3.574  1.632   1.00 47.01  ? 173 TYR B CE2 1 
ATOM   2634 C CZ  . TYR B 1 169 ? -26.170 -3.089  1.097   1.00 49.27  ? 173 TYR B CZ  1 
ATOM   2635 O OH  . TYR B 1 169 ? -25.187 -3.946  0.710   1.00 52.73  ? 173 TYR B OH  1 
ATOM   2636 N N   . ILE B 1 170 ? -29.070 1.889   0.004   1.00 42.34  ? 174 ILE B N   1 
ATOM   2637 C CA  . ILE B 1 170 ? -28.198 2.539   -0.999  1.00 40.36  ? 174 ILE B CA  1 
ATOM   2638 C C   . ILE B 1 170 ? -26.780 2.213   -0.585  1.00 44.68  ? 174 ILE B C   1 
ATOM   2639 O O   . ILE B 1 170 ? -26.418 2.555   0.559   1.00 47.23  ? 174 ILE B O   1 
ATOM   2640 C CB  . ILE B 1 170 ? -28.415 4.056   -1.034  1.00 44.87  ? 174 ILE B CB  1 
ATOM   2641 C CG1 . ILE B 1 170 ? -29.884 4.430   -1.295  1.00 45.04  ? 174 ILE B CG1 1 
ATOM   2642 C CG2 . ILE B 1 170 ? -27.422 4.676   -2.017  1.00 45.09  ? 174 ILE B CG2 1 
ATOM   2643 C CD1 . ILE B 1 170 ? -30.369 4.026   -2.634  1.00 48.23  ? 174 ILE B CD1 1 
ATOM   2644 N N   . GLY B 1 171 ? -26.036 1.554   -1.459  1.00 44.73  ? 175 GLY B N   1 
ATOM   2645 C CA  . GLY B 1 171 ? -24.629 1.209   -1.218  1.00 49.19  ? 175 GLY B CA  1 
ATOM   2646 C C   . GLY B 1 171 ? -23.716 2.078   -2.051  1.00 47.57  ? 175 GLY B C   1 
ATOM   2647 O O   . GLY B 1 171 ? -24.194 2.726   -2.984  1.00 45.88  ? 175 GLY B O   1 
ATOM   2648 N N   . LYS B 1 172 ? -22.432 2.104   -1.744  1.00 54.47  ? 176 LYS B N   1 
ATOM   2649 C CA  . LYS B 1 172 ? -21.476 2.764   -2.661  1.00 61.29  ? 176 LYS B CA  1 
ATOM   2650 C C   . LYS B 1 172 ? -20.397 1.744   -2.985  1.00 56.93  ? 176 LYS B C   1 
ATOM   2651 O O   . LYS B 1 172 ? -20.081 0.930   -2.100  1.00 53.59  ? 176 LYS B O   1 
ATOM   2652 C CB  . LYS B 1 172 ? -20.927 4.063   -2.078  1.00 64.73  ? 176 LYS B CB  1 
ATOM   2653 C CG  . LYS B 1 172 ? -20.143 3.933   -0.780  1.00 73.26  ? 176 LYS B CG  1 
ATOM   2654 C CD  . LYS B 1 172 ? -19.571 5.273   -0.358  1.00 76.97  ? 176 LYS B CD  1 
ATOM   2655 C CE  . LYS B 1 172 ? -18.924 5.269   1.010   1.00 83.78  ? 176 LYS B CE  1 
ATOM   2656 N NZ  . LYS B 1 172 ? -17.961 6.387   1.141   1.00 80.86  ? 176 LYS B NZ  1 
ATOM   2657 N N   . VAL B 1 173 ? -19.938 1.784   -4.230  1.00 53.38  ? 177 VAL B N   1 
ATOM   2658 C CA  . VAL B 1 173 ? -18.944 0.840   -4.798  1.00 61.81  ? 177 VAL B CA  1 
ATOM   2659 C C   . VAL B 1 173 ? -17.546 1.431   -4.557  1.00 64.37  ? 177 VAL B C   1 
ATOM   2660 O O   . VAL B 1 173 ? -17.300 2.554   -5.021  1.00 64.24  ? 177 VAL B O   1 
ATOM   2661 C CB  . VAL B 1 173 ? -19.220 0.609   -6.295  1.00 63.48  ? 177 VAL B CB  1 
ATOM   2662 C CG1 . VAL B 1 173 ? -18.073 -0.125  -6.974  1.00 71.32  ? 177 VAL B CG1 1 
ATOM   2663 C CG2 . VAL B 1 173 ? -20.529 -0.128  -6.519  1.00 64.89  ? 177 VAL B CG2 1 
ATOM   2664 N N   . ILE B 1 174 ? -16.682 0.697   -3.863  1.00 63.25  ? 178 ILE B N   1 
ATOM   2665 C CA  . ILE B 1 174 ? -15.229 1.008   -3.713  1.00 71.17  ? 178 ILE B CA  1 
ATOM   2666 C C   . ILE B 1 174 ? -14.434 0.172   -4.726  1.00 69.54  ? 178 ILE B C   1 
ATOM   2667 O O   . ILE B 1 174 ? -14.461 -1.065  -4.613  1.00 67.28  ? 178 ILE B O   1 
ATOM   2668 C CB  . ILE B 1 174 ? -14.771 0.721   -2.269  1.00 76.44  ? 178 ILE B CB  1 
ATOM   2669 C CG1 . ILE B 1 174 ? -15.772 1.249   -1.236  1.00 77.10  ? 178 ILE B CG1 1 
ATOM   2670 C CG2 . ILE B 1 174 ? -13.371 1.278   -2.043  1.00 79.13  ? 178 ILE B CG2 1 
ATOM   2671 C CD1 . ILE B 1 174 ? -16.166 2.708   -1.444  1.00 81.03  ? 178 ILE B CD1 1 
ATOM   2672 N N   . LEU B 1 175 ? -13.776 0.805   -5.697  1.00 74.71  ? 179 LEU B N   1 
ATOM   2673 C CA  . LEU B 1 175 ? -12.778 0.124   -6.567  1.00 72.39  ? 179 LEU B CA  1 
ATOM   2674 C C   . LEU B 1 175 ? -11.432 0.081   -5.834  1.00 65.75  ? 179 LEU B C   1 
ATOM   2675 O O   . LEU B 1 175 ? -11.081 -0.981  -5.313  1.00 71.47  ? 179 LEU B O   1 
ATOM   2676 C CB  . LEU B 1 175 ? -12.673 0.876   -7.892  1.00 72.43  ? 179 LEU B CB  1 
ATOM   2677 C CG  . LEU B 1 175 ? -13.997 1.078   -8.630  1.00 76.33  ? 179 LEU B CG  1 
ATOM   2678 C CD1 . LEU B 1 175 ? -13.782 1.763   -9.979  1.00 78.86  ? 179 LEU B CD1 1 
ATOM   2679 C CD2 . LEU B 1 175 ? -14.712 -0.247  -8.812  1.00 77.29  ? 179 LEU B CD2 1 
HETATM 2680 N N1  . EPE C 2 .   ? -53.140 -10.527 -16.363 1.00 68.89  ? 201 EPE A N1  1 
HETATM 2681 C C2  . EPE C 2 .   ? -54.151 -9.527  -16.747 1.00 79.72  ? 201 EPE A C2  1 
HETATM 2682 C C3  . EPE C 2 .   ? -53.571 -8.126  -16.724 1.00 85.21  ? 201 EPE A C3  1 
HETATM 2683 N N4  . EPE C 2 .   ? -52.925 -7.784  -15.425 1.00 89.56  ? 201 EPE A N4  1 
HETATM 2684 C C5  . EPE C 2 .   ? -51.951 -8.825  -15.052 1.00 74.76  ? 201 EPE A C5  1 
HETATM 2685 C C6  . EPE C 2 .   ? -52.609 -10.182 -15.031 1.00 69.65  ? 201 EPE A C6  1 
HETATM 2686 C C7  . EPE C 2 .   ? -52.310 -6.442  -15.397 1.00 90.28  ? 201 EPE A C7  1 
HETATM 2687 C C8  . EPE C 2 .   ? -51.103 -6.232  -16.316 1.00 86.68  ? 201 EPE A C8  1 
HETATM 2688 O O8  . EPE C 2 .   ? -49.867 -6.562  -15.701 1.00 74.03  ? 201 EPE A O8  1 
HETATM 2689 C C9  . EPE C 2 .   ? -53.643 -11.897 -16.375 1.00 68.89  ? 201 EPE A C9  1 
HETATM 2690 C C10 . EPE C 2 .   ? -52.468 -12.877 -16.374 1.00 61.02  ? 201 EPE A C10 1 
HETATM 2691 S S   . EPE C 2 .   ? -52.853 -14.451 -17.102 1.00 52.81  ? 201 EPE A S   1 
HETATM 2692 O O1S . EPE C 2 .   ? -53.471 -14.225 -18.382 1.00 53.94  ? 201 EPE A O1S 1 
HETATM 2693 O O2S . EPE C 2 .   ? -53.625 -15.146 -16.102 1.00 52.40  ? 201 EPE A O2S 1 
HETATM 2694 O O3S . EPE C 2 .   ? -51.454 -15.021 -17.378 1.00 44.43  ? 201 EPE A O3S 1 
HETATM 2695 N N1  . EPE D 2 .   ? -29.688 9.069   -14.837 1.00 62.49  ? 201 EPE B N1  1 
HETATM 2696 C C2  . EPE D 2 .   ? -29.192 7.999   -15.728 1.00 67.05  ? 201 EPE B C2  1 
HETATM 2697 C C3  . EPE D 2 .   ? -30.261 6.995   -16.100 1.00 74.59  ? 201 EPE B C3  1 
HETATM 2698 N N4  . EPE D 2 .   ? -30.995 6.410   -14.936 1.00 79.22  ? 201 EPE B N4  1 
HETATM 2699 C C5  . EPE D 2 .   ? -30.649 7.110   -13.695 1.00 73.83  ? 201 EPE B C5  1 
HETATM 2700 C C6  . EPE D 2 .   ? -30.734 8.595   -13.911 1.00 62.75  ? 201 EPE B C6  1 
HETATM 2701 C C7  . EPE D 2 .   ? -30.881 4.950   -14.815 1.00 86.86  ? 201 EPE B C7  1 
HETATM 2702 C C8  . EPE D 2 .   ? -29.907 4.456   -13.751 1.00 80.54  ? 201 EPE B C8  1 
HETATM 2703 O O8  . EPE D 2 .   ? -30.594 4.206   -12.543 1.00 57.42  ? 201 EPE B O8  1 
HETATM 2704 C C9  . EPE D 2 .   ? -30.142 10.267  -15.535 1.00 60.94  ? 201 EPE B C9  1 
HETATM 2705 C C10 . EPE D 2 .   ? -30.364 11.356  -14.510 1.00 56.73  ? 201 EPE B C10 1 
HETATM 2706 S S   . EPE D 2 .   ? -30.394 13.027  -15.089 1.00 52.29  ? 201 EPE B S   1 
HETATM 2707 O O1S . EPE D 2 .   ? -29.863 13.089  -16.419 1.00 50.94  ? 201 EPE B O1S 1 
HETATM 2708 O O2S . EPE D 2 .   ? -29.784 13.834  -14.078 1.00 56.07  ? 201 EPE B O2S 1 
HETATM 2709 O O3S . EPE D 2 .   ? -31.851 13.282  -15.209 1.00 38.85  ? 201 EPE B O3S 1 
HETATM 2710 O O   . HOH E 3 .   ? -53.170 3.376   -12.503 1.00 46.93  ? 301 HOH A O   1 
HETATM 2711 O O   . HOH E 3 .   ? -31.124 -23.812 -12.616 1.00 49.61  ? 302 HOH A O   1 
HETATM 2712 O O   . HOH E 3 .   ? -58.847 -11.586 -11.727 1.00 47.30  ? 303 HOH A O   1 
HETATM 2713 O O   . HOH E 3 .   ? -39.487 -6.992  0.881   1.00 48.15  ? 304 HOH A O   1 
HETATM 2714 O O   . HOH E 3 .   ? -51.382 4.983   -1.227  1.00 47.01  ? 305 HOH A O   1 
HETATM 2715 O O   . HOH E 3 .   ? -47.435 -5.508  -7.764  1.00 34.13  ? 306 HOH A O   1 
HETATM 2716 O O   . HOH E 3 .   ? -47.549 -3.531  1.160   1.00 37.87  ? 307 HOH A O   1 
HETATM 2717 O O   . HOH E 3 .   ? -47.444 -7.066  -19.263 1.00 38.41  ? 308 HOH A O   1 
HETATM 2718 O O   . HOH E 3 .   ? -56.559 5.118   -6.057  1.00 49.99  ? 309 HOH A O   1 
HETATM 2719 O O   . HOH E 3 .   ? -41.249 -21.743 -26.899 1.00 44.13  ? 310 HOH A O   1 
HETATM 2720 O O   . HOH E 3 .   ? -36.086 -20.531 -13.368 1.00 37.65  ? 311 HOH A O   1 
HETATM 2721 O O   . HOH E 3 .   ? -51.077 -18.306 1.380   1.00 36.79  ? 312 HOH A O   1 
HETATM 2722 O O   . HOH E 3 .   ? -60.032 -19.609 -7.861  1.00 38.30  ? 313 HOH A O   1 
HETATM 2723 O O   . HOH E 3 .   ? -50.752 -15.043 -28.910 1.00 49.25  ? 314 HOH A O   1 
HETATM 2724 O O   . HOH E 3 .   ? -38.246 -14.631 -28.047 1.00 41.51  ? 315 HOH A O   1 
HETATM 2725 O O   . HOH E 3 .   ? -44.826 -3.325  -29.873 1.00 42.14  ? 316 HOH A O   1 
HETATM 2726 O O   . HOH F 3 .   ? -32.006 18.169  -0.547  1.00 41.83  ? 301 HOH B O   1 
HETATM 2727 O O   . HOH F 3 .   ? -34.073 11.320  -32.381 1.00 39.57  ? 302 HOH B O   1 
HETATM 2728 O O   . HOH F 3 .   ? -35.871 2.452   -7.270  1.00 35.93  ? 303 HOH B O   1 
HETATM 2729 O O   . HOH F 3 .   ? -23.072 16.195  -4.859  1.00 39.33  ? 304 HOH B O   1 
HETATM 2730 O O   . HOH F 3 .   ? -47.463 18.035  -10.440 1.00 43.02  ? 305 HOH B O   1 
HETATM 2731 O O   . HOH F 3 .   ? -31.082 -3.625  5.090   1.00 49.30  ? 306 HOH B O   1 
HETATM 2732 O O   . HOH F 3 .   ? -41.836 4.715   4.297   1.00 46.45  ? 307 HOH B O   1 
HETATM 2733 O O   . HOH F 3 .   ? -48.465 10.058  3.976   1.00 45.82  ? 308 HOH B O   1 
HETATM 2734 O O   . HOH F 3 .   ? -35.645 -1.009  1.281   1.00 38.44  ? 309 HOH B O   1 
HETATM 2735 O O   . HOH F 3 .   ? -31.898 -9.096  -2.353  1.00 54.21  ? 310 HOH B O   1 
HETATM 2736 O O   . HOH F 3 .   ? -30.369 -5.809  -13.322 1.00 44.43  ? 311 HOH B O   1 
HETATM 2737 O O   . HOH F 3 .   ? -38.824 3.714   -29.245 1.00 41.38  ? 312 HOH B O   1 
HETATM 2738 O O   . HOH F 3 .   ? -54.199 3.361   -9.419  1.00 37.12  ? 313 HOH B O   1 
HETATM 2739 O O   . HOH F 3 .   ? -44.039 2.461   1.678   1.00 50.45  ? 314 HOH B O   1 
HETATM 2740 O O   . HOH F 3 .   ? -45.335 14.424  -25.813 1.00 47.32  ? 315 HOH B O   1 
HETATM 2741 O O   . HOH F 3 .   ? -26.673 8.631   7.013   1.00 46.48  ? 316 HOH B O   1 
HETATM 2742 O O   . HOH F 3 .   ? -34.162 9.492   7.036   1.00 40.81  ? 317 HOH B O   1 
HETATM 2743 O O   . HOH F 3 .   ? -47.624 3.786   -25.037 1.00 56.01  ? 318 HOH B O   1 
HETATM 2744 O O   . HOH F 3 .   ? -46.915 22.558  -13.114 1.00 46.78  ? 319 HOH B O   1 
HETATM 2745 O O   . HOH F 3 .   ? -29.505 -1.332  5.811   1.00 46.88  ? 320 HOH B O   1 
HETATM 2746 O O   . HOH F 3 .   ? -53.452 4.685   0.431   1.00 62.39  ? 321 HOH B O   1 
HETATM 2747 O O   . HOH F 3 .   ? -36.153 10.997  7.287   1.00 40.89  ? 322 HOH B O   1 
HETATM 2748 O O   . HOH F 3 .   ? -50.016 11.929  4.977   1.00 46.82  ? 323 HOH B O   1 
# 
