data_8K7S
# 
_entry.id   8K7S 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8K7S         pdb_00008k7s 10.2210/pdb8k7s/pdb 
WWPDB D_1300039720 ?            ?                   
EMDB  EMD-36940    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-12-04 
2 'Structure model' 1 1 2025-01-29 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Data collection'     
2 2 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 2 'Structure model' em_admin        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_CSD'          
4  2 'Structure model' '_citation.journal_id_ISSN'         
5  2 'Structure model' '_citation.journal_volume'          
6  2 'Structure model' '_citation.page_first'              
7  2 'Structure model' '_citation.page_last'               
8  2 'Structure model' '_citation.pdbx_database_id_DOI'    
9  2 'Structure model' '_citation.pdbx_database_id_PubMed' 
10 2 'Structure model' '_citation.title'                   
11 2 'Structure model' '_citation.year'                    
12 2 'Structure model' '_citation_author.identifier_ORCID' 
13 2 'Structure model' '_em_admin.last_update'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8K7S 
_pdbx_database_status.recvd_initial_deposition_date   2023-07-27 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Human Fc epsilon RI in complex with mIgE Fc (TMD disordered)' 
_pdbx_database_related.db_id          EMD-36940 
_pdbx_database_related.content_type   'associated EM volume' 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
3 zhang@mol.f.u-tokyo.ac.jp   Zhikuan   ZHANG   ? 'principal investigator/group leader' 0000-0001-6371-4391 
4 umeji@mol.f.u-tokyo.ac.jp   Umeharu   Ohto    ? 'principal investigator/group leader' 0000-0002-4422-4044 
5 shimizu@mol.f.u-tokyo.ac.jp Toshiyuki Shimizu ? 'principal investigator/group leader' 0000-0002-0547-8922 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zhang, Z.'   1 0000-0001-6371-4391 
'Yui, M.'     2 0009-0005-8139-9942 
'Ohto, U.'    3 0000-0002-4422-4044 
'Shimizu, T.' 4 0000-0002-0547-8922 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Sci.Signal. 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1937-9145 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            17 
_citation.language                  ? 
_citation.page_first                eadn1303 
_citation.page_last                 eadn1303 
_citation.title                     'Architecture of the high-affinity immunoglobulin E receptor.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1126/scisignal.adn1303 
_citation.pdbx_database_id_PubMed   39656861 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zhang, Z.'   1 ?                   
primary 'Yui, M.'     2 ?                   
primary 'Ohto, U.'    3 0000-0002-4422-4044 
primary 'Shimizu, T.' 4 0000-0002-0547-8922 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'IgE Fc' 40369.723 2 ? ? ? ? 
2 polymer     man FCER1A 32578.768 1 ? ? ? ? 
3 branched    syn 
;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
;
910.823   2 ? ? ? ? 
4 branched    man 
'beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose' 586.542   1 ? 
? ? ? 
5 non-polymer man 2-acetamido-2-deoxy-beta-D-glucopyranose 221.208   5 ? ? ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;METGLRWLLLVAVLKGVQCVRPVNITDPTLELLHSSCDPNAFHSTIQLYCFIYGHILNDVSVSWLMDDREITDTLAQTVL
IKEEGKLASTCSKLNITEQQWMSESTFTCKVTSQGVDYLAHTRRCPDHEPRGVITYLIPPSPLDLYQNGAPKLTCLVVDL
ESEKNVNVTWNQEKKTSVSASQWYTKHHNNATTSITSILPVVAKDWIEGYGYQCIVDHPDFPKPIVRSITKTPGQRSAPE
VYVFPPPEEESEDKRTLTCLIQNFFPEDISVQWLGDGKLISNSQHSTTTPLKSNGSNQGFFIFSRLEVAKTLWTQRKQFT
CQVIHEALQKPRKLEKTISTSLGNTSLRPSHHHHHH
;
;METGLRWLLLVAVLKGVQCVRPVNITDPTLELLHSSCDPNAFHSTIQLYCFIYGHILNDVSVSWLMDDREITDTLAQTVL
IKEEGKLASTCSKLNITEQQWMSESTFTCKVTSQGVDYLAHTRRCPDHEPRGVITYLIPPSPLDLYQNGAPKLTCLVVDL
ESEKNVNVTWNQEKKTSVSASQWYTKHHNNATTSITSILPVVAKDWIEGYGYQCIVDHPDFPKPIVRSITKTPGQRSAPE
VYVFPPPEEESEDKRTLTCLIQNFFPEDISVQWLGDGKLISNSQHSTTTPLKSNGSNQGFFIFSRLEVAKTLWTQRKQFT
CQVIHEALQKPRKLEKTISTSLGNTSLRPSHHHHHH
;
F,E ? 
2 'polypeptide(L)' no no 
;MAPAMESPTLLCVALLFFAPDGVLAVPQKPKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFHNGSLSEETNSSLNI
VNAKFEDSGEYKCQHQQVNESEPVYLEVFSDWLLLQASAEVVMEGQPLFLRCHGWRNWDVYKVIYYKDGEALKYWYENHN
ISITNATVEDSGTYYCTGKVWQLDYESEPLNITVIKAPREKYWLQFFIPLLVVILFAVDTGLFISTQQQVTFLLKIKRTR
KGFRLLNPHPKPNPKNNENLYFQGDYKDDDDKHHHHHHHH
;
;MAPAMESPTLLCVALLFFAPDGVLAVPQKPKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFHNGSLSEETNSSLNI
VNAKFEDSGEYKCQHQQVNESEPVYLEVFSDWLLLQASAEVVMEGQPLFLRCHGWRNWDVYKVIYYKDGEALKYWYENHN
ISITNATVEDSGTYYCTGKVWQLDYESEPLNITVIKAPREKYWLQFFIPLLVVILFAVDTGLFISTQQQVTFLLKIKRTR
KGFRLLNPHPKPNPKNNENLYFQGDYKDDDDKHHHHHHHH
;
A   ? 
# 
_pdbx_entity_nonpoly.entity_id   5 
_pdbx_entity_nonpoly.name        2-acetamido-2-deoxy-beta-D-glucopyranose 
_pdbx_entity_nonpoly.comp_id     NAG 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLU n 
1 3   THR n 
1 4   GLY n 
1 5   LEU n 
1 6   ARG n 
1 7   TRP n 
1 8   LEU n 
1 9   LEU n 
1 10  LEU n 
1 11  VAL n 
1 12  ALA n 
1 13  VAL n 
1 14  LEU n 
1 15  LYS n 
1 16  GLY n 
1 17  VAL n 
1 18  GLN n 
1 19  CYS n 
1 20  VAL n 
1 21  ARG n 
1 22  PRO n 
1 23  VAL n 
1 24  ASN n 
1 25  ILE n 
1 26  THR n 
1 27  ASP n 
1 28  PRO n 
1 29  THR n 
1 30  LEU n 
1 31  GLU n 
1 32  LEU n 
1 33  LEU n 
1 34  HIS n 
1 35  SER n 
1 36  SER n 
1 37  CYS n 
1 38  ASP n 
1 39  PRO n 
1 40  ASN n 
1 41  ALA n 
1 42  PHE n 
1 43  HIS n 
1 44  SER n 
1 45  THR n 
1 46  ILE n 
1 47  GLN n 
1 48  LEU n 
1 49  TYR n 
1 50  CYS n 
1 51  PHE n 
1 52  ILE n 
1 53  TYR n 
1 54  GLY n 
1 55  HIS n 
1 56  ILE n 
1 57  LEU n 
1 58  ASN n 
1 59  ASP n 
1 60  VAL n 
1 61  SER n 
1 62  VAL n 
1 63  SER n 
1 64  TRP n 
1 65  LEU n 
1 66  MET n 
1 67  ASP n 
1 68  ASP n 
1 69  ARG n 
1 70  GLU n 
1 71  ILE n 
1 72  THR n 
1 73  ASP n 
1 74  THR n 
1 75  LEU n 
1 76  ALA n 
1 77  GLN n 
1 78  THR n 
1 79  VAL n 
1 80  LEU n 
1 81  ILE n 
1 82  LYS n 
1 83  GLU n 
1 84  GLU n 
1 85  GLY n 
1 86  LYS n 
1 87  LEU n 
1 88  ALA n 
1 89  SER n 
1 90  THR n 
1 91  CYS n 
1 92  SER n 
1 93  LYS n 
1 94  LEU n 
1 95  ASN n 
1 96  ILE n 
1 97  THR n 
1 98  GLU n 
1 99  GLN n 
1 100 GLN n 
1 101 TRP n 
1 102 MET n 
1 103 SER n 
1 104 GLU n 
1 105 SER n 
1 106 THR n 
1 107 PHE n 
1 108 THR n 
1 109 CYS n 
1 110 LYS n 
1 111 VAL n 
1 112 THR n 
1 113 SER n 
1 114 GLN n 
1 115 GLY n 
1 116 VAL n 
1 117 ASP n 
1 118 TYR n 
1 119 LEU n 
1 120 ALA n 
1 121 HIS n 
1 122 THR n 
1 123 ARG n 
1 124 ARG n 
1 125 CYS n 
1 126 PRO n 
1 127 ASP n 
1 128 HIS n 
1 129 GLU n 
1 130 PRO n 
1 131 ARG n 
1 132 GLY n 
1 133 VAL n 
1 134 ILE n 
1 135 THR n 
1 136 TYR n 
1 137 LEU n 
1 138 ILE n 
1 139 PRO n 
1 140 PRO n 
1 141 SER n 
1 142 PRO n 
1 143 LEU n 
1 144 ASP n 
1 145 LEU n 
1 146 TYR n 
1 147 GLN n 
1 148 ASN n 
1 149 GLY n 
1 150 ALA n 
1 151 PRO n 
1 152 LYS n 
1 153 LEU n 
1 154 THR n 
1 155 CYS n 
1 156 LEU n 
1 157 VAL n 
1 158 VAL n 
1 159 ASP n 
1 160 LEU n 
1 161 GLU n 
1 162 SER n 
1 163 GLU n 
1 164 LYS n 
1 165 ASN n 
1 166 VAL n 
1 167 ASN n 
1 168 VAL n 
1 169 THR n 
1 170 TRP n 
1 171 ASN n 
1 172 GLN n 
1 173 GLU n 
1 174 LYS n 
1 175 LYS n 
1 176 THR n 
1 177 SER n 
1 178 VAL n 
1 179 SER n 
1 180 ALA n 
1 181 SER n 
1 182 GLN n 
1 183 TRP n 
1 184 TYR n 
1 185 THR n 
1 186 LYS n 
1 187 HIS n 
1 188 HIS n 
1 189 ASN n 
1 190 ASN n 
1 191 ALA n 
1 192 THR n 
1 193 THR n 
1 194 SER n 
1 195 ILE n 
1 196 THR n 
1 197 SER n 
1 198 ILE n 
1 199 LEU n 
1 200 PRO n 
1 201 VAL n 
1 202 VAL n 
1 203 ALA n 
1 204 LYS n 
1 205 ASP n 
1 206 TRP n 
1 207 ILE n 
1 208 GLU n 
1 209 GLY n 
1 210 TYR n 
1 211 GLY n 
1 212 TYR n 
1 213 GLN n 
1 214 CYS n 
1 215 ILE n 
1 216 VAL n 
1 217 ASP n 
1 218 HIS n 
1 219 PRO n 
1 220 ASP n 
1 221 PHE n 
1 222 PRO n 
1 223 LYS n 
1 224 PRO n 
1 225 ILE n 
1 226 VAL n 
1 227 ARG n 
1 228 SER n 
1 229 ILE n 
1 230 THR n 
1 231 LYS n 
1 232 THR n 
1 233 PRO n 
1 234 GLY n 
1 235 GLN n 
1 236 ARG n 
1 237 SER n 
1 238 ALA n 
1 239 PRO n 
1 240 GLU n 
1 241 VAL n 
1 242 TYR n 
1 243 VAL n 
1 244 PHE n 
1 245 PRO n 
1 246 PRO n 
1 247 PRO n 
1 248 GLU n 
1 249 GLU n 
1 250 GLU n 
1 251 SER n 
1 252 GLU n 
1 253 ASP n 
1 254 LYS n 
1 255 ARG n 
1 256 THR n 
1 257 LEU n 
1 258 THR n 
1 259 CYS n 
1 260 LEU n 
1 261 ILE n 
1 262 GLN n 
1 263 ASN n 
1 264 PHE n 
1 265 PHE n 
1 266 PRO n 
1 267 GLU n 
1 268 ASP n 
1 269 ILE n 
1 270 SER n 
1 271 VAL n 
1 272 GLN n 
1 273 TRP n 
1 274 LEU n 
1 275 GLY n 
1 276 ASP n 
1 277 GLY n 
1 278 LYS n 
1 279 LEU n 
1 280 ILE n 
1 281 SER n 
1 282 ASN n 
1 283 SER n 
1 284 GLN n 
1 285 HIS n 
1 286 SER n 
1 287 THR n 
1 288 THR n 
1 289 THR n 
1 290 PRO n 
1 291 LEU n 
1 292 LYS n 
1 293 SER n 
1 294 ASN n 
1 295 GLY n 
1 296 SER n 
1 297 ASN n 
1 298 GLN n 
1 299 GLY n 
1 300 PHE n 
1 301 PHE n 
1 302 ILE n 
1 303 PHE n 
1 304 SER n 
1 305 ARG n 
1 306 LEU n 
1 307 GLU n 
1 308 VAL n 
1 309 ALA n 
1 310 LYS n 
1 311 THR n 
1 312 LEU n 
1 313 TRP n 
1 314 THR n 
1 315 GLN n 
1 316 ARG n 
1 317 LYS n 
1 318 GLN n 
1 319 PHE n 
1 320 THR n 
1 321 CYS n 
1 322 GLN n 
1 323 VAL n 
1 324 ILE n 
1 325 HIS n 
1 326 GLU n 
1 327 ALA n 
1 328 LEU n 
1 329 GLN n 
1 330 LYS n 
1 331 PRO n 
1 332 ARG n 
1 333 LYS n 
1 334 LEU n 
1 335 GLU n 
1 336 LYS n 
1 337 THR n 
1 338 ILE n 
1 339 SER n 
1 340 THR n 
1 341 SER n 
1 342 LEU n 
1 343 GLY n 
1 344 ASN n 
1 345 THR n 
1 346 SER n 
1 347 LEU n 
1 348 ARG n 
1 349 PRO n 
1 350 SER n 
1 351 HIS n 
1 352 HIS n 
1 353 HIS n 
1 354 HIS n 
1 355 HIS n 
1 356 HIS n 
2 1   MET n 
2 2   ALA n 
2 3   PRO n 
2 4   ALA n 
2 5   MET n 
2 6   GLU n 
2 7   SER n 
2 8   PRO n 
2 9   THR n 
2 10  LEU n 
2 11  LEU n 
2 12  CYS n 
2 13  VAL n 
2 14  ALA n 
2 15  LEU n 
2 16  LEU n 
2 17  PHE n 
2 18  PHE n 
2 19  ALA n 
2 20  PRO n 
2 21  ASP n 
2 22  GLY n 
2 23  VAL n 
2 24  LEU n 
2 25  ALA n 
2 26  VAL n 
2 27  PRO n 
2 28  GLN n 
2 29  LYS n 
2 30  PRO n 
2 31  LYS n 
2 32  VAL n 
2 33  SER n 
2 34  LEU n 
2 35  ASN n 
2 36  PRO n 
2 37  PRO n 
2 38  TRP n 
2 39  ASN n 
2 40  ARG n 
2 41  ILE n 
2 42  PHE n 
2 43  LYS n 
2 44  GLY n 
2 45  GLU n 
2 46  ASN n 
2 47  VAL n 
2 48  THR n 
2 49  LEU n 
2 50  THR n 
2 51  CYS n 
2 52  ASN n 
2 53  GLY n 
2 54  ASN n 
2 55  ASN n 
2 56  PHE n 
2 57  PHE n 
2 58  GLU n 
2 59  VAL n 
2 60  SER n 
2 61  SER n 
2 62  THR n 
2 63  LYS n 
2 64  TRP n 
2 65  PHE n 
2 66  HIS n 
2 67  ASN n 
2 68  GLY n 
2 69  SER n 
2 70  LEU n 
2 71  SER n 
2 72  GLU n 
2 73  GLU n 
2 74  THR n 
2 75  ASN n 
2 76  SER n 
2 77  SER n 
2 78  LEU n 
2 79  ASN n 
2 80  ILE n 
2 81  VAL n 
2 82  ASN n 
2 83  ALA n 
2 84  LYS n 
2 85  PHE n 
2 86  GLU n 
2 87  ASP n 
2 88  SER n 
2 89  GLY n 
2 90  GLU n 
2 91  TYR n 
2 92  LYS n 
2 93  CYS n 
2 94  GLN n 
2 95  HIS n 
2 96  GLN n 
2 97  GLN n 
2 98  VAL n 
2 99  ASN n 
2 100 GLU n 
2 101 SER n 
2 102 GLU n 
2 103 PRO n 
2 104 VAL n 
2 105 TYR n 
2 106 LEU n 
2 107 GLU n 
2 108 VAL n 
2 109 PHE n 
2 110 SER n 
2 111 ASP n 
2 112 TRP n 
2 113 LEU n 
2 114 LEU n 
2 115 LEU n 
2 116 GLN n 
2 117 ALA n 
2 118 SER n 
2 119 ALA n 
2 120 GLU n 
2 121 VAL n 
2 122 VAL n 
2 123 MET n 
2 124 GLU n 
2 125 GLY n 
2 126 GLN n 
2 127 PRO n 
2 128 LEU n 
2 129 PHE n 
2 130 LEU n 
2 131 ARG n 
2 132 CYS n 
2 133 HIS n 
2 134 GLY n 
2 135 TRP n 
2 136 ARG n 
2 137 ASN n 
2 138 TRP n 
2 139 ASP n 
2 140 VAL n 
2 141 TYR n 
2 142 LYS n 
2 143 VAL n 
2 144 ILE n 
2 145 TYR n 
2 146 TYR n 
2 147 LYS n 
2 148 ASP n 
2 149 GLY n 
2 150 GLU n 
2 151 ALA n 
2 152 LEU n 
2 153 LYS n 
2 154 TYR n 
2 155 TRP n 
2 156 TYR n 
2 157 GLU n 
2 158 ASN n 
2 159 HIS n 
2 160 ASN n 
2 161 ILE n 
2 162 SER n 
2 163 ILE n 
2 164 THR n 
2 165 ASN n 
2 166 ALA n 
2 167 THR n 
2 168 VAL n 
2 169 GLU n 
2 170 ASP n 
2 171 SER n 
2 172 GLY n 
2 173 THR n 
2 174 TYR n 
2 175 TYR n 
2 176 CYS n 
2 177 THR n 
2 178 GLY n 
2 179 LYS n 
2 180 VAL n 
2 181 TRP n 
2 182 GLN n 
2 183 LEU n 
2 184 ASP n 
2 185 TYR n 
2 186 GLU n 
2 187 SER n 
2 188 GLU n 
2 189 PRO n 
2 190 LEU n 
2 191 ASN n 
2 192 ILE n 
2 193 THR n 
2 194 VAL n 
2 195 ILE n 
2 196 LYS n 
2 197 ALA n 
2 198 PRO n 
2 199 ARG n 
2 200 GLU n 
2 201 LYS n 
2 202 TYR n 
2 203 TRP n 
2 204 LEU n 
2 205 GLN n 
2 206 PHE n 
2 207 PHE n 
2 208 ILE n 
2 209 PRO n 
2 210 LEU n 
2 211 LEU n 
2 212 VAL n 
2 213 VAL n 
2 214 ILE n 
2 215 LEU n 
2 216 PHE n 
2 217 ALA n 
2 218 VAL n 
2 219 ASP n 
2 220 THR n 
2 221 GLY n 
2 222 LEU n 
2 223 PHE n 
2 224 ILE n 
2 225 SER n 
2 226 THR n 
2 227 GLN n 
2 228 GLN n 
2 229 GLN n 
2 230 VAL n 
2 231 THR n 
2 232 PHE n 
2 233 LEU n 
2 234 LEU n 
2 235 LYS n 
2 236 ILE n 
2 237 LYS n 
2 238 ARG n 
2 239 THR n 
2 240 ARG n 
2 241 LYS n 
2 242 GLY n 
2 243 PHE n 
2 244 ARG n 
2 245 LEU n 
2 246 LEU n 
2 247 ASN n 
2 248 PRO n 
2 249 HIS n 
2 250 PRO n 
2 251 LYS n 
2 252 PRO n 
2 253 ASN n 
2 254 PRO n 
2 255 LYS n 
2 256 ASN n 
2 257 ASN n 
2 258 GLU n 
2 259 ASN n 
2 260 LEU n 
2 261 TYR n 
2 262 PHE n 
2 263 GLN n 
2 264 GLY n 
2 265 ASP n 
2 266 TYR n 
2 267 LYS n 
2 268 ASP n 
2 269 ASP n 
2 270 ASP n 
2 271 ASP n 
2 272 LYS n 
2 273 HIS n 
2 274 HIS n 
2 275 HIS n 
2 276 HIS n 
2 277 HIS n 
2 278 HIS n 
2 279 HIS n 
2 280 HIS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 356 ? ? ? ? ? ? ? ? ? 'Mus musculus' 10090 ? ? ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 280 ? ? ? ? ? ? ? ? ? 'Homo sapiens' 9606  ? ? ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_pdbx_entity_branch.entity_id 
_pdbx_entity_branch.type 
3 oligosaccharide 
4 oligosaccharide 
# 
loop_
_pdbx_entity_branch_descriptor.ordinal 
_pdbx_entity_branch_descriptor.entity_id 
_pdbx_entity_branch_descriptor.descriptor 
_pdbx_entity_branch_descriptor.type 
_pdbx_entity_branch_descriptor.program 
_pdbx_entity_branch_descriptor.program_version 
1 3 'DManpa1-3[DManpa1-6]DManpb1-4DGlcpNAcb1-4DGlcpNAcb1-ROH'                                                   
'Glycam Condensed Sequence' GMML       1.0   
2 3 'WURCS=2.0/3,5,4/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1122h-1a_1-5]/1-1-2-3-3/a4-b1_b4-c1_c3-d1_c6-e1' WURCS PDB2Glycan 
1.1.0 
3 3 '[][D-1-deoxy-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-Manp]{[(3+1)][a-D-Manp]{}[(6+1)][a-D-Manp]{}}}}'    LINUCS PDB-CARE   
?     
4 4 DManpb1-4DGlcpNAcb1-4DGlcpNAcb1-ROH                                                                         
'Glycam Condensed Sequence' GMML       1.0   
5 4 'WURCS=2.0/2,3,2/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5]/1-1-2/a4-b1_b4-c1'                                WURCS PDB2Glycan 
1.1.0 
6 4 '[][D-1-deoxy-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-Manp]{}}}'                                          LINUCS PDB-CARE   
?     
# 
loop_
_pdbx_entity_branch_link.link_id 
_pdbx_entity_branch_link.entity_id 
_pdbx_entity_branch_link.entity_branch_list_num_1 
_pdbx_entity_branch_link.comp_id_1 
_pdbx_entity_branch_link.atom_id_1 
_pdbx_entity_branch_link.leaving_atom_id_1 
_pdbx_entity_branch_link.entity_branch_list_num_2 
_pdbx_entity_branch_link.comp_id_2 
_pdbx_entity_branch_link.atom_id_2 
_pdbx_entity_branch_link.leaving_atom_id_2 
_pdbx_entity_branch_link.value_order 
_pdbx_entity_branch_link.details 
1 3 2 NAG C1 O1 1 NAG O4 HO4 sing ? 
2 3 3 BMA C1 O1 2 NAG O4 HO4 sing ? 
3 3 4 MAN C1 O1 3 BMA O3 HO3 sing ? 
4 3 5 MAN C1 O1 3 BMA O6 HO6 sing ? 
5 4 2 NAG C1 O1 1 NAG O4 HO4 sing ? 
6 4 3 BMA C1 O1 2 NAG O4 HO4 sing ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'           y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'           y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'           y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'           y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
BMA 'D-saccharide, beta linking'  . beta-D-mannopyranose                     'beta-D-mannose; D-mannose; mannose' 'C6 H12 O6'      
180.156 
CYS 'L-peptide linking'           y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking'           y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'           y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'             y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'           y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking'           y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'           y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'           y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MAN 'D-saccharide, alpha linking' . alpha-D-mannopyranose                    'alpha-D-mannose; D-mannose; mannose' 'C6 H12 O6' 
180.156 
MET 'L-peptide linking'           y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking'  . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'           y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'           y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'           y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'           y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'           y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'           y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'           y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
BMA 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DManpb                         
BMA 'COMMON NAME'                         GMML     1.0 b-D-mannopyranose              
BMA 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-Manp                       
BMA 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 Man                            
MAN 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DManpa                         
MAN 'COMMON NAME'                         GMML     1.0 a-D-mannopyranose              
MAN 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 a-D-Manp                       
MAN 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 Man                            
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   72  ?   ?   ?   F . n 
A 1 2   GLU 2   73  ?   ?   ?   F . n 
A 1 3   THR 3   74  ?   ?   ?   F . n 
A 1 4   GLY 4   75  ?   ?   ?   F . n 
A 1 5   LEU 5   76  ?   ?   ?   F . n 
A 1 6   ARG 6   77  ?   ?   ?   F . n 
A 1 7   TRP 7   78  ?   ?   ?   F . n 
A 1 8   LEU 8   79  ?   ?   ?   F . n 
A 1 9   LEU 9   80  ?   ?   ?   F . n 
A 1 10  LEU 10  81  ?   ?   ?   F . n 
A 1 11  VAL 11  82  ?   ?   ?   F . n 
A 1 12  ALA 12  83  ?   ?   ?   F . n 
A 1 13  VAL 13  84  ?   ?   ?   F . n 
A 1 14  LEU 14  85  ?   ?   ?   F . n 
A 1 15  LYS 15  86  ?   ?   ?   F . n 
A 1 16  GLY 16  87  ?   ?   ?   F . n 
A 1 17  VAL 17  88  ?   ?   ?   F . n 
A 1 18  GLN 18  89  ?   ?   ?   F . n 
A 1 19  CYS 19  90  ?   ?   ?   F . n 
A 1 20  VAL 20  91  ?   ?   ?   F . n 
A 1 21  ARG 21  92  ?   ?   ?   F . n 
A 1 22  PRO 22  93  ?   ?   ?   F . n 
A 1 23  VAL 23  94  ?   ?   ?   F . n 
A 1 24  ASN 24  95  ?   ?   ?   F . n 
A 1 25  ILE 25  96  ?   ?   ?   F . n 
A 1 26  THR 26  97  ?   ?   ?   F . n 
A 1 27  ASP 27  98  98  ASP ASP F . n 
A 1 28  PRO 28  99  99  PRO PRO F . n 
A 1 29  THR 29  100 100 THR THR F . n 
A 1 30  LEU 30  101 101 LEU LEU F . n 
A 1 31  GLU 31  102 102 GLU GLU F . n 
A 1 32  LEU 32  103 103 LEU LEU F . n 
A 1 33  LEU 33  104 104 LEU LEU F . n 
A 1 34  HIS 34  105 105 HIS HIS F . n 
A 1 35  SER 35  106 106 SER SER F . n 
A 1 36  SER 36  107 107 SER SER F . n 
A 1 37  CYS 37  108 108 CYS CYS F . n 
A 1 38  ASP 38  109 109 ASP ASP F . n 
A 1 39  PRO 39  110 110 PRO PRO F . n 
A 1 40  ASN 40  111 111 ASN ASN F . n 
A 1 41  ALA 41  112 112 ALA ALA F . n 
A 1 42  PHE 42  113 113 PHE PHE F . n 
A 1 43  HIS 43  114 114 HIS HIS F . n 
A 1 44  SER 44  115 115 SER SER F . n 
A 1 45  THR 45  116 116 THR THR F . n 
A 1 46  ILE 46  117 117 ILE ILE F . n 
A 1 47  GLN 47  118 118 GLN GLN F . n 
A 1 48  LEU 48  119 119 LEU LEU F . n 
A 1 49  TYR 49  120 120 TYR TYR F . n 
A 1 50  CYS 50  121 121 CYS CYS F . n 
A 1 51  PHE 51  122 122 PHE PHE F . n 
A 1 52  ILE 52  123 123 ILE ILE F . n 
A 1 53  TYR 53  124 124 TYR TYR F . n 
A 1 54  GLY 54  125 125 GLY GLY F . n 
A 1 55  HIS 55  126 126 HIS HIS F . n 
A 1 56  ILE 56  127 127 ILE ILE F . n 
A 1 57  LEU 57  128 128 LEU LEU F . n 
A 1 58  ASN 58  129 129 ASN ASN F . n 
A 1 59  ASP 59  130 130 ASP ASP F . n 
A 1 60  VAL 60  131 131 VAL VAL F . n 
A 1 61  SER 61  132 132 SER SER F . n 
A 1 62  VAL 62  133 133 VAL VAL F . n 
A 1 63  SER 63  134 134 SER SER F . n 
A 1 64  TRP 64  135 135 TRP TRP F . n 
A 1 65  LEU 65  136 136 LEU LEU F . n 
A 1 66  MET 66  137 137 MET MET F . n 
A 1 67  ASP 67  138 138 ASP ASP F . n 
A 1 68  ASP 68  139 139 ASP ASP F . n 
A 1 69  ARG 69  140 140 ARG ARG F . n 
A 1 70  GLU 70  141 141 GLU GLU F . n 
A 1 71  ILE 71  142 142 ILE ILE F . n 
A 1 72  THR 72  143 143 THR THR F . n 
A 1 73  ASP 73  144 144 ASP ASP F . n 
A 1 74  THR 74  145 145 THR THR F . n 
A 1 75  LEU 75  146 146 LEU LEU F . n 
A 1 76  ALA 76  147 147 ALA ALA F . n 
A 1 77  GLN 77  148 148 GLN GLN F . n 
A 1 78  THR 78  149 149 THR THR F . n 
A 1 79  VAL 79  150 150 VAL VAL F . n 
A 1 80  LEU 80  151 151 LEU LEU F . n 
A 1 81  ILE 81  152 152 ILE ILE F . n 
A 1 82  LYS 82  153 153 LYS LYS F . n 
A 1 83  GLU 83  154 154 GLU GLU F . n 
A 1 84  GLU 84  155 155 GLU GLU F . n 
A 1 85  GLY 85  156 156 GLY GLY F . n 
A 1 86  LYS 86  157 157 LYS LYS F . n 
A 1 87  LEU 87  158 158 LEU LEU F . n 
A 1 88  ALA 88  159 159 ALA ALA F . n 
A 1 89  SER 89  160 160 SER SER F . n 
A 1 90  THR 90  161 161 THR THR F . n 
A 1 91  CYS 91  162 162 CYS CYS F . n 
A 1 92  SER 92  163 163 SER SER F . n 
A 1 93  LYS 93  164 164 LYS LYS F . n 
A 1 94  LEU 94  165 165 LEU LEU F . n 
A 1 95  ASN 95  166 166 ASN ASN F . n 
A 1 96  ILE 96  167 167 ILE ILE F . n 
A 1 97  THR 97  168 168 THR THR F . n 
A 1 98  GLU 98  169 169 GLU GLU F . n 
A 1 99  GLN 99  170 170 GLN GLN F . n 
A 1 100 GLN 100 171 171 GLN GLN F . n 
A 1 101 TRP 101 172 172 TRP TRP F . n 
A 1 102 MET 102 173 173 MET MET F . n 
A 1 103 SER 103 174 174 SER SER F . n 
A 1 104 GLU 104 175 175 GLU GLU F . n 
A 1 105 SER 105 176 176 SER SER F . n 
A 1 106 THR 106 177 177 THR THR F . n 
A 1 107 PHE 107 178 178 PHE PHE F . n 
A 1 108 THR 108 179 179 THR THR F . n 
A 1 109 CYS 109 180 180 CYS CYS F . n 
A 1 110 LYS 110 181 181 LYS LYS F . n 
A 1 111 VAL 111 182 182 VAL VAL F . n 
A 1 112 THR 112 183 183 THR THR F . n 
A 1 113 SER 113 184 184 SER SER F . n 
A 1 114 GLN 114 185 185 GLN GLN F . n 
A 1 115 GLY 115 186 186 GLY GLY F . n 
A 1 116 VAL 116 187 187 VAL VAL F . n 
A 1 117 ASP 117 188 188 ASP ASP F . n 
A 1 118 TYR 118 189 189 TYR TYR F . n 
A 1 119 LEU 119 190 190 LEU LEU F . n 
A 1 120 ALA 120 191 191 ALA ALA F . n 
A 1 121 HIS 121 192 192 HIS HIS F . n 
A 1 122 THR 122 193 193 THR THR F . n 
A 1 123 ARG 123 194 194 ARG ARG F . n 
A 1 124 ARG 124 195 195 ARG ARG F . n 
A 1 125 CYS 125 196 196 CYS CYS F . n 
A 1 126 PRO 126 197 197 PRO PRO F . n 
A 1 127 ASP 127 198 198 ASP ASP F . n 
A 1 128 HIS 128 199 199 HIS HIS F . n 
A 1 129 GLU 129 200 200 GLU GLU F . n 
A 1 130 PRO 130 201 201 PRO PRO F . n 
A 1 131 ARG 131 202 202 ARG ARG F . n 
A 1 132 GLY 132 203 203 GLY GLY F . n 
A 1 133 VAL 133 204 204 VAL VAL F . n 
A 1 134 ILE 134 205 205 ILE ILE F . n 
A 1 135 THR 135 206 206 THR THR F . n 
A 1 136 TYR 136 207 207 TYR TYR F . n 
A 1 137 LEU 137 208 208 LEU LEU F . n 
A 1 138 ILE 138 209 209 ILE ILE F . n 
A 1 139 PRO 139 210 210 PRO PRO F . n 
A 1 140 PRO 140 211 211 PRO PRO F . n 
A 1 141 SER 141 212 212 SER SER F . n 
A 1 142 PRO 142 213 213 PRO PRO F . n 
A 1 143 LEU 143 214 214 LEU LEU F . n 
A 1 144 ASP 144 215 215 ASP ASP F . n 
A 1 145 LEU 145 216 216 LEU LEU F . n 
A 1 146 TYR 146 217 217 TYR TYR F . n 
A 1 147 GLN 147 218 218 GLN GLN F . n 
A 1 148 ASN 148 219 219 ASN ASN F . n 
A 1 149 GLY 149 220 220 GLY GLY F . n 
A 1 150 ALA 150 221 221 ALA ALA F . n 
A 1 151 PRO 151 222 222 PRO PRO F . n 
A 1 152 LYS 152 223 223 LYS LYS F . n 
A 1 153 LEU 153 224 224 LEU LEU F . n 
A 1 154 THR 154 225 225 THR THR F . n 
A 1 155 CYS 155 226 226 CYS CYS F . n 
A 1 156 LEU 156 227 227 LEU LEU F . n 
A 1 157 VAL 157 228 228 VAL VAL F . n 
A 1 158 VAL 158 229 229 VAL VAL F . n 
A 1 159 ASP 159 230 230 ASP ASP F . n 
A 1 160 LEU 160 231 231 LEU LEU F . n 
A 1 161 GLU 161 232 232 GLU GLU F . n 
A 1 162 SER 162 233 233 SER SER F . n 
A 1 163 GLU 163 234 234 GLU GLU F . n 
A 1 164 LYS 164 235 235 LYS LYS F . n 
A 1 165 ASN 165 236 236 ASN ASN F . n 
A 1 166 VAL 166 237 237 VAL VAL F . n 
A 1 167 ASN 167 238 238 ASN ASN F . n 
A 1 168 VAL 168 239 239 VAL VAL F . n 
A 1 169 THR 169 240 240 THR THR F . n 
A 1 170 TRP 170 241 241 TRP TRP F . n 
A 1 171 ASN 171 242 242 ASN ASN F . n 
A 1 172 GLN 172 243 243 GLN GLN F . n 
A 1 173 GLU 173 244 244 GLU GLU F . n 
A 1 174 LYS 174 245 245 LYS LYS F . n 
A 1 175 LYS 175 246 246 LYS LYS F . n 
A 1 176 THR 176 247 247 THR THR F . n 
A 1 177 SER 177 248 248 SER SER F . n 
A 1 178 VAL 178 249 249 VAL VAL F . n 
A 1 179 SER 179 250 250 SER SER F . n 
A 1 180 ALA 180 251 251 ALA ALA F . n 
A 1 181 SER 181 252 252 SER SER F . n 
A 1 182 GLN 182 253 253 GLN GLN F . n 
A 1 183 TRP 183 254 254 TRP TRP F . n 
A 1 184 TYR 184 255 255 TYR TYR F . n 
A 1 185 THR 185 256 256 THR THR F . n 
A 1 186 LYS 186 257 257 LYS LYS F . n 
A 1 187 HIS 187 258 258 HIS HIS F . n 
A 1 188 HIS 188 259 259 HIS HIS F . n 
A 1 189 ASN 189 260 260 ASN ASN F . n 
A 1 190 ASN 190 261 261 ASN ASN F . n 
A 1 191 ALA 191 262 262 ALA ALA F . n 
A 1 192 THR 192 263 263 THR THR F . n 
A 1 193 THR 193 264 264 THR THR F . n 
A 1 194 SER 194 265 265 SER SER F . n 
A 1 195 ILE 195 266 266 ILE ILE F . n 
A 1 196 THR 196 267 267 THR THR F . n 
A 1 197 SER 197 268 268 SER SER F . n 
A 1 198 ILE 198 269 269 ILE ILE F . n 
A 1 199 LEU 199 270 270 LEU LEU F . n 
A 1 200 PRO 200 271 271 PRO PRO F . n 
A 1 201 VAL 201 272 272 VAL VAL F . n 
A 1 202 VAL 202 273 273 VAL VAL F . n 
A 1 203 ALA 203 274 274 ALA ALA F . n 
A 1 204 LYS 204 275 275 LYS LYS F . n 
A 1 205 ASP 205 276 276 ASP ASP F . n 
A 1 206 TRP 206 277 277 TRP TRP F . n 
A 1 207 ILE 207 278 278 ILE ILE F . n 
A 1 208 GLU 208 279 279 GLU GLU F . n 
A 1 209 GLY 209 280 280 GLY GLY F . n 
A 1 210 TYR 210 281 281 TYR TYR F . n 
A 1 211 GLY 211 282 282 GLY GLY F . n 
A 1 212 TYR 212 283 283 TYR TYR F . n 
A 1 213 GLN 213 284 284 GLN GLN F . n 
A 1 214 CYS 214 285 285 CYS CYS F . n 
A 1 215 ILE 215 286 286 ILE ILE F . n 
A 1 216 VAL 216 287 287 VAL VAL F . n 
A 1 217 ASP 217 288 288 ASP ASP F . n 
A 1 218 HIS 218 289 289 HIS HIS F . n 
A 1 219 PRO 219 290 290 PRO PRO F . n 
A 1 220 ASP 220 291 291 ASP ASP F . n 
A 1 221 PHE 221 292 292 PHE PHE F . n 
A 1 222 PRO 222 293 293 PRO PRO F . n 
A 1 223 LYS 223 294 294 LYS LYS F . n 
A 1 224 PRO 224 295 295 PRO PRO F . n 
A 1 225 ILE 225 296 296 ILE ILE F . n 
A 1 226 VAL 226 297 297 VAL VAL F . n 
A 1 227 ARG 227 298 298 ARG ARG F . n 
A 1 228 SER 228 299 299 SER SER F . n 
A 1 229 ILE 229 300 300 ILE ILE F . n 
A 1 230 THR 230 301 301 THR THR F . n 
A 1 231 LYS 231 302 302 LYS LYS F . n 
A 1 232 THR 232 303 303 THR THR F . n 
A 1 233 PRO 233 304 304 PRO PRO F . n 
A 1 234 GLY 234 305 305 GLY GLY F . n 
A 1 235 GLN 235 306 306 GLN GLN F . n 
A 1 236 ARG 236 307 307 ARG ARG F . n 
A 1 237 SER 237 308 308 SER SER F . n 
A 1 238 ALA 238 309 309 ALA ALA F . n 
A 1 239 PRO 239 310 310 PRO PRO F . n 
A 1 240 GLU 240 311 311 GLU GLU F . n 
A 1 241 VAL 241 312 312 VAL VAL F . n 
A 1 242 TYR 242 313 313 TYR TYR F . n 
A 1 243 VAL 243 314 314 VAL VAL F . n 
A 1 244 PHE 244 315 315 PHE PHE F . n 
A 1 245 PRO 245 316 316 PRO PRO F . n 
A 1 246 PRO 246 317 317 PRO PRO F . n 
A 1 247 PRO 247 318 318 PRO PRO F . n 
A 1 248 GLU 248 319 319 GLU GLU F . n 
A 1 249 GLU 249 320 320 GLU GLU F . n 
A 1 250 GLU 250 321 321 GLU GLU F . n 
A 1 251 SER 251 322 322 SER SER F . n 
A 1 252 GLU 252 323 323 GLU GLU F . n 
A 1 253 ASP 253 324 324 ASP ASP F . n 
A 1 254 LYS 254 325 325 LYS LYS F . n 
A 1 255 ARG 255 326 326 ARG ARG F . n 
A 1 256 THR 256 327 327 THR THR F . n 
A 1 257 LEU 257 328 328 LEU LEU F . n 
A 1 258 THR 258 329 329 THR THR F . n 
A 1 259 CYS 259 330 330 CYS CYS F . n 
A 1 260 LEU 260 331 331 LEU LEU F . n 
A 1 261 ILE 261 332 332 ILE ILE F . n 
A 1 262 GLN 262 333 333 GLN GLN F . n 
A 1 263 ASN 263 334 334 ASN ASN F . n 
A 1 264 PHE 264 335 335 PHE PHE F . n 
A 1 265 PHE 265 336 336 PHE PHE F . n 
A 1 266 PRO 266 337 337 PRO PRO F . n 
A 1 267 GLU 267 338 338 GLU GLU F . n 
A 1 268 ASP 268 339 339 ASP ASP F . n 
A 1 269 ILE 269 340 340 ILE ILE F . n 
A 1 270 SER 270 341 341 SER SER F . n 
A 1 271 VAL 271 342 342 VAL VAL F . n 
A 1 272 GLN 272 343 343 GLN GLN F . n 
A 1 273 TRP 273 344 344 TRP TRP F . n 
A 1 274 LEU 274 345 345 LEU LEU F . n 
A 1 275 GLY 275 346 346 GLY GLY F . n 
A 1 276 ASP 276 347 347 ASP ASP F . n 
A 1 277 GLY 277 348 348 GLY GLY F . n 
A 1 278 LYS 278 349 349 LYS LYS F . n 
A 1 279 LEU 279 350 350 LEU LEU F . n 
A 1 280 ILE 280 351 351 ILE ILE F . n 
A 1 281 SER 281 352 352 SER SER F . n 
A 1 282 ASN 282 353 353 ASN ASN F . n 
A 1 283 SER 283 354 354 SER SER F . n 
A 1 284 GLN 284 355 355 GLN GLN F . n 
A 1 285 HIS 285 356 356 HIS HIS F . n 
A 1 286 SER 286 357 357 SER SER F . n 
A 1 287 THR 287 358 358 THR THR F . n 
A 1 288 THR 288 359 359 THR THR F . n 
A 1 289 THR 289 360 360 THR THR F . n 
A 1 290 PRO 290 361 361 PRO PRO F . n 
A 1 291 LEU 291 362 362 LEU LEU F . n 
A 1 292 LYS 292 363 363 LYS LYS F . n 
A 1 293 SER 293 364 364 SER SER F . n 
A 1 294 ASN 294 365 365 ASN ASN F . n 
A 1 295 GLY 295 366 366 GLY GLY F . n 
A 1 296 SER 296 367 367 SER SER F . n 
A 1 297 ASN 297 368 368 ASN ASN F . n 
A 1 298 GLN 298 369 369 GLN GLN F . n 
A 1 299 GLY 299 370 370 GLY GLY F . n 
A 1 300 PHE 300 371 371 PHE PHE F . n 
A 1 301 PHE 301 372 372 PHE PHE F . n 
A 1 302 ILE 302 373 373 ILE ILE F . n 
A 1 303 PHE 303 374 374 PHE PHE F . n 
A 1 304 SER 304 375 375 SER SER F . n 
A 1 305 ARG 305 376 376 ARG ARG F . n 
A 1 306 LEU 306 377 377 LEU LEU F . n 
A 1 307 GLU 307 378 378 GLU GLU F . n 
A 1 308 VAL 308 379 379 VAL VAL F . n 
A 1 309 ALA 309 380 380 ALA ALA F . n 
A 1 310 LYS 310 381 381 LYS LYS F . n 
A 1 311 THR 311 382 382 THR THR F . n 
A 1 312 LEU 312 383 383 LEU LEU F . n 
A 1 313 TRP 313 384 384 TRP TRP F . n 
A 1 314 THR 314 385 385 THR THR F . n 
A 1 315 GLN 315 386 386 GLN GLN F . n 
A 1 316 ARG 316 387 387 ARG ARG F . n 
A 1 317 LYS 317 388 388 LYS LYS F . n 
A 1 318 GLN 318 389 389 GLN GLN F . n 
A 1 319 PHE 319 390 390 PHE PHE F . n 
A 1 320 THR 320 391 391 THR THR F . n 
A 1 321 CYS 321 392 392 CYS CYS F . n 
A 1 322 GLN 322 393 393 GLN GLN F . n 
A 1 323 VAL 323 394 394 VAL VAL F . n 
A 1 324 ILE 324 395 395 ILE ILE F . n 
A 1 325 HIS 325 396 396 HIS HIS F . n 
A 1 326 GLU 326 397 397 GLU GLU F . n 
A 1 327 ALA 327 398 398 ALA ALA F . n 
A 1 328 LEU 328 399 399 LEU LEU F . n 
A 1 329 GLN 329 400 400 GLN GLN F . n 
A 1 330 LYS 330 401 401 LYS LYS F . n 
A 1 331 PRO 331 402 402 PRO PRO F . n 
A 1 332 ARG 332 403 403 ARG ARG F . n 
A 1 333 LYS 333 404 404 LYS LYS F . n 
A 1 334 LEU 334 405 405 LEU LEU F . n 
A 1 335 GLU 335 406 406 GLU GLU F . n 
A 1 336 LYS 336 407 407 LYS LYS F . n 
A 1 337 THR 337 408 408 THR THR F . n 
A 1 338 ILE 338 409 409 ILE ILE F . n 
A 1 339 SER 339 410 410 SER SER F . n 
A 1 340 THR 340 411 411 THR THR F . n 
A 1 341 SER 341 412 412 SER SER F . n 
A 1 342 LEU 342 413 413 LEU LEU F . n 
A 1 343 GLY 343 414 ?   ?   ?   F . n 
A 1 344 ASN 344 415 ?   ?   ?   F . n 
A 1 345 THR 345 416 ?   ?   ?   F . n 
A 1 346 SER 346 417 ?   ?   ?   F . n 
A 1 347 LEU 347 418 ?   ?   ?   F . n 
A 1 348 ARG 348 419 ?   ?   ?   F . n 
A 1 349 PRO 349 420 ?   ?   ?   F . n 
A 1 350 SER 350 421 ?   ?   ?   F . n 
A 1 351 HIS 351 422 ?   ?   ?   F . n 
A 1 352 HIS 352 423 ?   ?   ?   F . n 
A 1 353 HIS 353 424 ?   ?   ?   F . n 
A 1 354 HIS 354 425 ?   ?   ?   F . n 
A 1 355 HIS 355 426 ?   ?   ?   F . n 
A 1 356 HIS 356 427 ?   ?   ?   F . n 
B 2 1   MET 1   1   ?   ?   ?   A . n 
B 2 2   ALA 2   2   ?   ?   ?   A . n 
B 2 3   PRO 3   3   ?   ?   ?   A . n 
B 2 4   ALA 4   4   ?   ?   ?   A . n 
B 2 5   MET 5   5   ?   ?   ?   A . n 
B 2 6   GLU 6   6   ?   ?   ?   A . n 
B 2 7   SER 7   7   ?   ?   ?   A . n 
B 2 8   PRO 8   8   ?   ?   ?   A . n 
B 2 9   THR 9   9   ?   ?   ?   A . n 
B 2 10  LEU 10  10  ?   ?   ?   A . n 
B 2 11  LEU 11  11  ?   ?   ?   A . n 
B 2 12  CYS 12  12  ?   ?   ?   A . n 
B 2 13  VAL 13  13  ?   ?   ?   A . n 
B 2 14  ALA 14  14  ?   ?   ?   A . n 
B 2 15  LEU 15  15  ?   ?   ?   A . n 
B 2 16  LEU 16  16  ?   ?   ?   A . n 
B 2 17  PHE 17  17  ?   ?   ?   A . n 
B 2 18  PHE 18  18  ?   ?   ?   A . n 
B 2 19  ALA 19  19  ?   ?   ?   A . n 
B 2 20  PRO 20  20  ?   ?   ?   A . n 
B 2 21  ASP 21  21  ?   ?   ?   A . n 
B 2 22  GLY 22  22  ?   ?   ?   A . n 
B 2 23  VAL 23  23  ?   ?   ?   A . n 
B 2 24  LEU 24  24  ?   ?   ?   A . n 
B 2 25  ALA 25  25  ?   ?   ?   A . n 
B 2 26  VAL 26  26  ?   ?   ?   A . n 
B 2 27  PRO 27  27  ?   ?   ?   A . n 
B 2 28  GLN 28  28  ?   ?   ?   A . n 
B 2 29  LYS 29  29  29  LYS LYS A . n 
B 2 30  PRO 30  30  30  PRO PRO A . n 
B 2 31  LYS 31  31  31  LYS LYS A . n 
B 2 32  VAL 32  32  32  VAL VAL A . n 
B 2 33  SER 33  33  33  SER SER A . n 
B 2 34  LEU 34  34  34  LEU LEU A . n 
B 2 35  ASN 35  35  35  ASN ASN A . n 
B 2 36  PRO 36  36  36  PRO PRO A . n 
B 2 37  PRO 37  37  37  PRO PRO A . n 
B 2 38  TRP 38  38  38  TRP TRP A . n 
B 2 39  ASN 39  39  39  ASN ASN A . n 
B 2 40  ARG 40  40  40  ARG ARG A . n 
B 2 41  ILE 41  41  41  ILE ILE A . n 
B 2 42  PHE 42  42  42  PHE PHE A . n 
B 2 43  LYS 43  43  43  LYS LYS A . n 
B 2 44  GLY 44  44  44  GLY GLY A . n 
B 2 45  GLU 45  45  45  GLU GLU A . n 
B 2 46  ASN 46  46  46  ASN ASN A . n 
B 2 47  VAL 47  47  47  VAL VAL A . n 
B 2 48  THR 48  48  48  THR THR A . n 
B 2 49  LEU 49  49  49  LEU LEU A . n 
B 2 50  THR 50  50  50  THR THR A . n 
B 2 51  CYS 51  51  51  CYS CYS A . n 
B 2 52  ASN 52  52  52  ASN ASN A . n 
B 2 53  GLY 53  53  53  GLY GLY A . n 
B 2 54  ASN 54  54  54  ASN ASN A . n 
B 2 55  ASN 55  55  55  ASN ASN A . n 
B 2 56  PHE 56  56  56  PHE PHE A . n 
B 2 57  PHE 57  57  57  PHE PHE A . n 
B 2 58  GLU 58  58  58  GLU GLU A . n 
B 2 59  VAL 59  59  59  VAL VAL A . n 
B 2 60  SER 60  60  60  SER SER A . n 
B 2 61  SER 61  61  61  SER SER A . n 
B 2 62  THR 62  62  62  THR THR A . n 
B 2 63  LYS 63  63  63  LYS LYS A . n 
B 2 64  TRP 64  64  64  TRP TRP A . n 
B 2 65  PHE 65  65  65  PHE PHE A . n 
B 2 66  HIS 66  66  66  HIS HIS A . n 
B 2 67  ASN 67  67  67  ASN ASN A . n 
B 2 68  GLY 68  68  68  GLY GLY A . n 
B 2 69  SER 69  69  69  SER SER A . n 
B 2 70  LEU 70  70  70  LEU LEU A . n 
B 2 71  SER 71  71  71  SER SER A . n 
B 2 72  GLU 72  72  72  GLU GLU A . n 
B 2 73  GLU 73  73  73  GLU GLU A . n 
B 2 74  THR 74  74  74  THR THR A . n 
B 2 75  ASN 75  75  75  ASN ASN A . n 
B 2 76  SER 76  76  76  SER SER A . n 
B 2 77  SER 77  77  77  SER SER A . n 
B 2 78  LEU 78  78  78  LEU LEU A . n 
B 2 79  ASN 79  79  79  ASN ASN A . n 
B 2 80  ILE 80  80  80  ILE ILE A . n 
B 2 81  VAL 81  81  81  VAL VAL A . n 
B 2 82  ASN 82  82  82  ASN ASN A . n 
B 2 83  ALA 83  83  83  ALA ALA A . n 
B 2 84  LYS 84  84  84  LYS LYS A . n 
B 2 85  PHE 85  85  85  PHE PHE A . n 
B 2 86  GLU 86  86  86  GLU GLU A . n 
B 2 87  ASP 87  87  87  ASP ASP A . n 
B 2 88  SER 88  88  88  SER SER A . n 
B 2 89  GLY 89  89  89  GLY GLY A . n 
B 2 90  GLU 90  90  90  GLU GLU A . n 
B 2 91  TYR 91  91  91  TYR TYR A . n 
B 2 92  LYS 92  92  92  LYS LYS A . n 
B 2 93  CYS 93  93  93  CYS CYS A . n 
B 2 94  GLN 94  94  94  GLN GLN A . n 
B 2 95  HIS 95  95  95  HIS HIS A . n 
B 2 96  GLN 96  96  96  GLN GLN A . n 
B 2 97  GLN 97  97  97  GLN GLN A . n 
B 2 98  VAL 98  98  98  VAL VAL A . n 
B 2 99  ASN 99  99  99  ASN ASN A . n 
B 2 100 GLU 100 100 100 GLU GLU A . n 
B 2 101 SER 101 101 101 SER SER A . n 
B 2 102 GLU 102 102 102 GLU GLU A . n 
B 2 103 PRO 103 103 103 PRO PRO A . n 
B 2 104 VAL 104 104 104 VAL VAL A . n 
B 2 105 TYR 105 105 105 TYR TYR A . n 
B 2 106 LEU 106 106 106 LEU LEU A . n 
B 2 107 GLU 107 107 107 GLU GLU A . n 
B 2 108 VAL 108 108 108 VAL VAL A . n 
B 2 109 PHE 109 109 109 PHE PHE A . n 
B 2 110 SER 110 110 110 SER SER A . n 
B 2 111 ASP 111 111 111 ASP ASP A . n 
B 2 112 TRP 112 112 112 TRP TRP A . n 
B 2 113 LEU 113 113 113 LEU LEU A . n 
B 2 114 LEU 114 114 114 LEU LEU A . n 
B 2 115 LEU 115 115 115 LEU LEU A . n 
B 2 116 GLN 116 116 116 GLN GLN A . n 
B 2 117 ALA 117 117 117 ALA ALA A . n 
B 2 118 SER 118 118 118 SER SER A . n 
B 2 119 ALA 119 119 119 ALA ALA A . n 
B 2 120 GLU 120 120 120 GLU GLU A . n 
B 2 121 VAL 121 121 121 VAL VAL A . n 
B 2 122 VAL 122 122 122 VAL VAL A . n 
B 2 123 MET 123 123 123 MET MET A . n 
B 2 124 GLU 124 124 124 GLU GLU A . n 
B 2 125 GLY 125 125 125 GLY GLY A . n 
B 2 126 GLN 126 126 126 GLN GLN A . n 
B 2 127 PRO 127 127 127 PRO PRO A . n 
B 2 128 LEU 128 128 128 LEU LEU A . n 
B 2 129 PHE 129 129 129 PHE PHE A . n 
B 2 130 LEU 130 130 130 LEU LEU A . n 
B 2 131 ARG 131 131 131 ARG ARG A . n 
B 2 132 CYS 132 132 132 CYS CYS A . n 
B 2 133 HIS 133 133 133 HIS HIS A . n 
B 2 134 GLY 134 134 134 GLY GLY A . n 
B 2 135 TRP 135 135 135 TRP TRP A . n 
B 2 136 ARG 136 136 136 ARG ARG A . n 
B 2 137 ASN 137 137 137 ASN ASN A . n 
B 2 138 TRP 138 138 138 TRP TRP A . n 
B 2 139 ASP 139 139 139 ASP ASP A . n 
B 2 140 VAL 140 140 140 VAL VAL A . n 
B 2 141 TYR 141 141 141 TYR TYR A . n 
B 2 142 LYS 142 142 142 LYS LYS A . n 
B 2 143 VAL 143 143 143 VAL VAL A . n 
B 2 144 ILE 144 144 144 ILE ILE A . n 
B 2 145 TYR 145 145 145 TYR TYR A . n 
B 2 146 TYR 146 146 146 TYR TYR A . n 
B 2 147 LYS 147 147 147 LYS LYS A . n 
B 2 148 ASP 148 148 148 ASP ASP A . n 
B 2 149 GLY 149 149 149 GLY GLY A . n 
B 2 150 GLU 150 150 150 GLU GLU A . n 
B 2 151 ALA 151 151 151 ALA ALA A . n 
B 2 152 LEU 152 152 152 LEU LEU A . n 
B 2 153 LYS 153 153 153 LYS LYS A . n 
B 2 154 TYR 154 154 154 TYR TYR A . n 
B 2 155 TRP 155 155 155 TRP TRP A . n 
B 2 156 TYR 156 156 156 TYR TYR A . n 
B 2 157 GLU 157 157 157 GLU GLU A . n 
B 2 158 ASN 158 158 158 ASN ASN A . n 
B 2 159 HIS 159 159 159 HIS HIS A . n 
B 2 160 ASN 160 160 160 ASN ASN A . n 
B 2 161 ILE 161 161 161 ILE ILE A . n 
B 2 162 SER 162 162 162 SER SER A . n 
B 2 163 ILE 163 163 163 ILE ILE A . n 
B 2 164 THR 164 164 164 THR THR A . n 
B 2 165 ASN 165 165 165 ASN ASN A . n 
B 2 166 ALA 166 166 166 ALA ALA A . n 
B 2 167 THR 167 167 167 THR THR A . n 
B 2 168 VAL 168 168 168 VAL VAL A . n 
B 2 169 GLU 169 169 169 GLU GLU A . n 
B 2 170 ASP 170 170 170 ASP ASP A . n 
B 2 171 SER 171 171 171 SER SER A . n 
B 2 172 GLY 172 172 172 GLY GLY A . n 
B 2 173 THR 173 173 173 THR THR A . n 
B 2 174 TYR 174 174 174 TYR TYR A . n 
B 2 175 TYR 175 175 175 TYR TYR A . n 
B 2 176 CYS 176 176 176 CYS CYS A . n 
B 2 177 THR 177 177 177 THR THR A . n 
B 2 178 GLY 178 178 178 GLY GLY A . n 
B 2 179 LYS 179 179 179 LYS LYS A . n 
B 2 180 VAL 180 180 180 VAL VAL A . n 
B 2 181 TRP 181 181 181 TRP TRP A . n 
B 2 182 GLN 182 182 182 GLN GLN A . n 
B 2 183 LEU 183 183 183 LEU LEU A . n 
B 2 184 ASP 184 184 184 ASP ASP A . n 
B 2 185 TYR 185 185 185 TYR TYR A . n 
B 2 186 GLU 186 186 186 GLU GLU A . n 
B 2 187 SER 187 187 187 SER SER A . n 
B 2 188 GLU 188 188 188 GLU GLU A . n 
B 2 189 PRO 189 189 189 PRO PRO A . n 
B 2 190 LEU 190 190 190 LEU LEU A . n 
B 2 191 ASN 191 191 191 ASN ASN A . n 
B 2 192 ILE 192 192 192 ILE ILE A . n 
B 2 193 THR 193 193 193 THR THR A . n 
B 2 194 VAL 194 194 194 VAL VAL A . n 
B 2 195 ILE 195 195 195 ILE ILE A . n 
B 2 196 LYS 196 196 ?   ?   ?   A . n 
B 2 197 ALA 197 197 ?   ?   ?   A . n 
B 2 198 PRO 198 198 ?   ?   ?   A . n 
B 2 199 ARG 199 199 ?   ?   ?   A . n 
B 2 200 GLU 200 200 ?   ?   ?   A . n 
B 2 201 LYS 201 201 ?   ?   ?   A . n 
B 2 202 TYR 202 202 ?   ?   ?   A . n 
B 2 203 TRP 203 203 ?   ?   ?   A . n 
B 2 204 LEU 204 204 ?   ?   ?   A . n 
B 2 205 GLN 205 205 ?   ?   ?   A . n 
B 2 206 PHE 206 206 ?   ?   ?   A . n 
B 2 207 PHE 207 207 ?   ?   ?   A . n 
B 2 208 ILE 208 208 ?   ?   ?   A . n 
B 2 209 PRO 209 209 ?   ?   ?   A . n 
B 2 210 LEU 210 210 ?   ?   ?   A . n 
B 2 211 LEU 211 211 ?   ?   ?   A . n 
B 2 212 VAL 212 212 ?   ?   ?   A . n 
B 2 213 VAL 213 213 ?   ?   ?   A . n 
B 2 214 ILE 214 214 ?   ?   ?   A . n 
B 2 215 LEU 215 215 ?   ?   ?   A . n 
B 2 216 PHE 216 216 ?   ?   ?   A . n 
B 2 217 ALA 217 217 ?   ?   ?   A . n 
B 2 218 VAL 218 218 ?   ?   ?   A . n 
B 2 219 ASP 219 219 ?   ?   ?   A . n 
B 2 220 THR 220 220 ?   ?   ?   A . n 
B 2 221 GLY 221 221 ?   ?   ?   A . n 
B 2 222 LEU 222 222 ?   ?   ?   A . n 
B 2 223 PHE 223 223 ?   ?   ?   A . n 
B 2 224 ILE 224 224 ?   ?   ?   A . n 
B 2 225 SER 225 225 ?   ?   ?   A . n 
B 2 226 THR 226 226 ?   ?   ?   A . n 
B 2 227 GLN 227 227 ?   ?   ?   A . n 
B 2 228 GLN 228 228 ?   ?   ?   A . n 
B 2 229 GLN 229 229 ?   ?   ?   A . n 
B 2 230 VAL 230 230 ?   ?   ?   A . n 
B 2 231 THR 231 231 ?   ?   ?   A . n 
B 2 232 PHE 232 232 ?   ?   ?   A . n 
B 2 233 LEU 233 233 ?   ?   ?   A . n 
B 2 234 LEU 234 234 ?   ?   ?   A . n 
B 2 235 LYS 235 235 ?   ?   ?   A . n 
B 2 236 ILE 236 236 ?   ?   ?   A . n 
B 2 237 LYS 237 237 ?   ?   ?   A . n 
B 2 238 ARG 238 238 ?   ?   ?   A . n 
B 2 239 THR 239 239 ?   ?   ?   A . n 
B 2 240 ARG 240 240 ?   ?   ?   A . n 
B 2 241 LYS 241 241 ?   ?   ?   A . n 
B 2 242 GLY 242 242 ?   ?   ?   A . n 
B 2 243 PHE 243 243 ?   ?   ?   A . n 
B 2 244 ARG 244 244 ?   ?   ?   A . n 
B 2 245 LEU 245 245 ?   ?   ?   A . n 
B 2 246 LEU 246 246 ?   ?   ?   A . n 
B 2 247 ASN 247 247 ?   ?   ?   A . n 
B 2 248 PRO 248 248 ?   ?   ?   A . n 
B 2 249 HIS 249 249 ?   ?   ?   A . n 
B 2 250 PRO 250 250 ?   ?   ?   A . n 
B 2 251 LYS 251 251 ?   ?   ?   A . n 
B 2 252 PRO 252 252 ?   ?   ?   A . n 
B 2 253 ASN 253 253 ?   ?   ?   A . n 
B 2 254 PRO 254 254 ?   ?   ?   A . n 
B 2 255 LYS 255 255 ?   ?   ?   A . n 
B 2 256 ASN 256 256 ?   ?   ?   A . n 
B 2 257 ASN 257 257 ?   ?   ?   A . n 
B 2 258 GLU 258 258 ?   ?   ?   A . n 
B 2 259 ASN 259 259 ?   ?   ?   A . n 
B 2 260 LEU 260 260 ?   ?   ?   A . n 
B 2 261 TYR 261 261 ?   ?   ?   A . n 
B 2 262 PHE 262 262 ?   ?   ?   A . n 
B 2 263 GLN 263 263 ?   ?   ?   A . n 
B 2 264 GLY 264 264 ?   ?   ?   A . n 
B 2 265 ASP 265 265 ?   ?   ?   A . n 
B 2 266 TYR 266 266 ?   ?   ?   A . n 
B 2 267 LYS 267 267 ?   ?   ?   A . n 
B 2 268 ASP 268 268 ?   ?   ?   A . n 
B 2 269 ASP 269 269 ?   ?   ?   A . n 
B 2 270 ASP 270 270 ?   ?   ?   A . n 
B 2 271 ASP 271 271 ?   ?   ?   A . n 
B 2 272 LYS 272 272 ?   ?   ?   A . n 
B 2 273 HIS 273 273 ?   ?   ?   A . n 
B 2 274 HIS 274 274 ?   ?   ?   A . n 
B 2 275 HIS 275 275 ?   ?   ?   A . n 
B 2 276 HIS 276 276 ?   ?   ?   A . n 
B 2 277 HIS 277 277 ?   ?   ?   A . n 
B 2 278 HIS 278 278 ?   ?   ?   A . n 
B 2 279 HIS 279 279 ?   ?   ?   A . n 
B 2 280 HIS 280 280 ?   ?   ?   A . n 
C 1 1   MET 1   72  ?   ?   ?   E . n 
C 1 2   GLU 2   73  ?   ?   ?   E . n 
C 1 3   THR 3   74  ?   ?   ?   E . n 
C 1 4   GLY 4   75  ?   ?   ?   E . n 
C 1 5   LEU 5   76  ?   ?   ?   E . n 
C 1 6   ARG 6   77  ?   ?   ?   E . n 
C 1 7   TRP 7   78  ?   ?   ?   E . n 
C 1 8   LEU 8   79  ?   ?   ?   E . n 
C 1 9   LEU 9   80  ?   ?   ?   E . n 
C 1 10  LEU 10  81  ?   ?   ?   E . n 
C 1 11  VAL 11  82  ?   ?   ?   E . n 
C 1 12  ALA 12  83  ?   ?   ?   E . n 
C 1 13  VAL 13  84  ?   ?   ?   E . n 
C 1 14  LEU 14  85  ?   ?   ?   E . n 
C 1 15  LYS 15  86  ?   ?   ?   E . n 
C 1 16  GLY 16  87  ?   ?   ?   E . n 
C 1 17  VAL 17  88  ?   ?   ?   E . n 
C 1 18  GLN 18  89  ?   ?   ?   E . n 
C 1 19  CYS 19  90  ?   ?   ?   E . n 
C 1 20  VAL 20  91  ?   ?   ?   E . n 
C 1 21  ARG 21  92  ?   ?   ?   E . n 
C 1 22  PRO 22  93  ?   ?   ?   E . n 
C 1 23  VAL 23  94  ?   ?   ?   E . n 
C 1 24  ASN 24  95  ?   ?   ?   E . n 
C 1 25  ILE 25  96  ?   ?   ?   E . n 
C 1 26  THR 26  97  ?   ?   ?   E . n 
C 1 27  ASP 27  98  98  ASP ASP E . n 
C 1 28  PRO 28  99  99  PRO PRO E . n 
C 1 29  THR 29  100 100 THR THR E . n 
C 1 30  LEU 30  101 101 LEU LEU E . n 
C 1 31  GLU 31  102 102 GLU GLU E . n 
C 1 32  LEU 32  103 103 LEU LEU E . n 
C 1 33  LEU 33  104 104 LEU LEU E . n 
C 1 34  HIS 34  105 105 HIS HIS E . n 
C 1 35  SER 35  106 106 SER SER E . n 
C 1 36  SER 36  107 107 SER SER E . n 
C 1 37  CYS 37  108 108 CYS CYS E . n 
C 1 38  ASP 38  109 109 ASP ASP E . n 
C 1 39  PRO 39  110 110 PRO PRO E . n 
C 1 40  ASN 40  111 111 ASN ASN E . n 
C 1 41  ALA 41  112 112 ALA ALA E . n 
C 1 42  PHE 42  113 113 PHE PHE E . n 
C 1 43  HIS 43  114 114 HIS HIS E . n 
C 1 44  SER 44  115 115 SER SER E . n 
C 1 45  THR 45  116 116 THR THR E . n 
C 1 46  ILE 46  117 117 ILE ILE E . n 
C 1 47  GLN 47  118 118 GLN GLN E . n 
C 1 48  LEU 48  119 119 LEU LEU E . n 
C 1 49  TYR 49  120 120 TYR TYR E . n 
C 1 50  CYS 50  121 121 CYS CYS E . n 
C 1 51  PHE 51  122 122 PHE PHE E . n 
C 1 52  ILE 52  123 123 ILE ILE E . n 
C 1 53  TYR 53  124 124 TYR TYR E . n 
C 1 54  GLY 54  125 125 GLY GLY E . n 
C 1 55  HIS 55  126 126 HIS HIS E . n 
C 1 56  ILE 56  127 127 ILE ILE E . n 
C 1 57  LEU 57  128 128 LEU LEU E . n 
C 1 58  ASN 58  129 129 ASN ASN E . n 
C 1 59  ASP 59  130 130 ASP ASP E . n 
C 1 60  VAL 60  131 131 VAL VAL E . n 
C 1 61  SER 61  132 132 SER SER E . n 
C 1 62  VAL 62  133 133 VAL VAL E . n 
C 1 63  SER 63  134 134 SER SER E . n 
C 1 64  TRP 64  135 135 TRP TRP E . n 
C 1 65  LEU 65  136 136 LEU LEU E . n 
C 1 66  MET 66  137 137 MET MET E . n 
C 1 67  ASP 67  138 138 ASP ASP E . n 
C 1 68  ASP 68  139 139 ASP ASP E . n 
C 1 69  ARG 69  140 140 ARG ARG E . n 
C 1 70  GLU 70  141 141 GLU GLU E . n 
C 1 71  ILE 71  142 142 ILE ILE E . n 
C 1 72  THR 72  143 143 THR THR E . n 
C 1 73  ASP 73  144 144 ASP ASP E . n 
C 1 74  THR 74  145 145 THR THR E . n 
C 1 75  LEU 75  146 146 LEU LEU E . n 
C 1 76  ALA 76  147 147 ALA ALA E . n 
C 1 77  GLN 77  148 148 GLN GLN E . n 
C 1 78  THR 78  149 149 THR THR E . n 
C 1 79  VAL 79  150 150 VAL VAL E . n 
C 1 80  LEU 80  151 151 LEU LEU E . n 
C 1 81  ILE 81  152 152 ILE ILE E . n 
C 1 82  LYS 82  153 153 LYS LYS E . n 
C 1 83  GLU 83  154 154 GLU GLU E . n 
C 1 84  GLU 84  155 155 GLU GLU E . n 
C 1 85  GLY 85  156 156 GLY GLY E . n 
C 1 86  LYS 86  157 157 LYS LYS E . n 
C 1 87  LEU 87  158 158 LEU LEU E . n 
C 1 88  ALA 88  159 159 ALA ALA E . n 
C 1 89  SER 89  160 160 SER SER E . n 
C 1 90  THR 90  161 161 THR THR E . n 
C 1 91  CYS 91  162 162 CYS CYS E . n 
C 1 92  SER 92  163 163 SER SER E . n 
C 1 93  LYS 93  164 164 LYS LYS E . n 
C 1 94  LEU 94  165 165 LEU LEU E . n 
C 1 95  ASN 95  166 166 ASN ASN E . n 
C 1 96  ILE 96  167 167 ILE ILE E . n 
C 1 97  THR 97  168 168 THR THR E . n 
C 1 98  GLU 98  169 169 GLU GLU E . n 
C 1 99  GLN 99  170 170 GLN GLN E . n 
C 1 100 GLN 100 171 171 GLN GLN E . n 
C 1 101 TRP 101 172 172 TRP TRP E . n 
C 1 102 MET 102 173 173 MET MET E . n 
C 1 103 SER 103 174 174 SER SER E . n 
C 1 104 GLU 104 175 175 GLU GLU E . n 
C 1 105 SER 105 176 176 SER SER E . n 
C 1 106 THR 106 177 177 THR THR E . n 
C 1 107 PHE 107 178 178 PHE PHE E . n 
C 1 108 THR 108 179 179 THR THR E . n 
C 1 109 CYS 109 180 180 CYS CYS E . n 
C 1 110 LYS 110 181 181 LYS LYS E . n 
C 1 111 VAL 111 182 182 VAL VAL E . n 
C 1 112 THR 112 183 183 THR THR E . n 
C 1 113 SER 113 184 184 SER SER E . n 
C 1 114 GLN 114 185 185 GLN GLN E . n 
C 1 115 GLY 115 186 186 GLY GLY E . n 
C 1 116 VAL 116 187 187 VAL VAL E . n 
C 1 117 ASP 117 188 188 ASP ASP E . n 
C 1 118 TYR 118 189 189 TYR TYR E . n 
C 1 119 LEU 119 190 190 LEU LEU E . n 
C 1 120 ALA 120 191 191 ALA ALA E . n 
C 1 121 HIS 121 192 192 HIS HIS E . n 
C 1 122 THR 122 193 193 THR THR E . n 
C 1 123 ARG 123 194 194 ARG ARG E . n 
C 1 124 ARG 124 195 195 ARG ARG E . n 
C 1 125 CYS 125 196 196 CYS CYS E . n 
C 1 126 PRO 126 197 197 PRO PRO E . n 
C 1 127 ASP 127 198 198 ASP ASP E . n 
C 1 128 HIS 128 199 199 HIS HIS E . n 
C 1 129 GLU 129 200 200 GLU GLU E . n 
C 1 130 PRO 130 201 201 PRO PRO E . n 
C 1 131 ARG 131 202 202 ARG ARG E . n 
C 1 132 GLY 132 203 203 GLY GLY E . n 
C 1 133 VAL 133 204 204 VAL VAL E . n 
C 1 134 ILE 134 205 205 ILE ILE E . n 
C 1 135 THR 135 206 206 THR THR E . n 
C 1 136 TYR 136 207 207 TYR TYR E . n 
C 1 137 LEU 137 208 208 LEU LEU E . n 
C 1 138 ILE 138 209 209 ILE ILE E . n 
C 1 139 PRO 139 210 210 PRO PRO E . n 
C 1 140 PRO 140 211 211 PRO PRO E . n 
C 1 141 SER 141 212 212 SER SER E . n 
C 1 142 PRO 142 213 213 PRO PRO E . n 
C 1 143 LEU 143 214 214 LEU LEU E . n 
C 1 144 ASP 144 215 215 ASP ASP E . n 
C 1 145 LEU 145 216 216 LEU LEU E . n 
C 1 146 TYR 146 217 217 TYR TYR E . n 
C 1 147 GLN 147 218 218 GLN GLN E . n 
C 1 148 ASN 148 219 219 ASN ASN E . n 
C 1 149 GLY 149 220 220 GLY GLY E . n 
C 1 150 ALA 150 221 221 ALA ALA E . n 
C 1 151 PRO 151 222 222 PRO PRO E . n 
C 1 152 LYS 152 223 223 LYS LYS E . n 
C 1 153 LEU 153 224 224 LEU LEU E . n 
C 1 154 THR 154 225 225 THR THR E . n 
C 1 155 CYS 155 226 226 CYS CYS E . n 
C 1 156 LEU 156 227 227 LEU LEU E . n 
C 1 157 VAL 157 228 228 VAL VAL E . n 
C 1 158 VAL 158 229 229 VAL VAL E . n 
C 1 159 ASP 159 230 230 ASP ASP E . n 
C 1 160 LEU 160 231 231 LEU LEU E . n 
C 1 161 GLU 161 232 232 GLU GLU E . n 
C 1 162 SER 162 233 233 SER SER E . n 
C 1 163 GLU 163 234 234 GLU GLU E . n 
C 1 164 LYS 164 235 235 LYS LYS E . n 
C 1 165 ASN 165 236 236 ASN ASN E . n 
C 1 166 VAL 166 237 237 VAL VAL E . n 
C 1 167 ASN 167 238 238 ASN ASN E . n 
C 1 168 VAL 168 239 239 VAL VAL E . n 
C 1 169 THR 169 240 240 THR THR E . n 
C 1 170 TRP 170 241 241 TRP TRP E . n 
C 1 171 ASN 171 242 242 ASN ASN E . n 
C 1 172 GLN 172 243 243 GLN GLN E . n 
C 1 173 GLU 173 244 244 GLU GLU E . n 
C 1 174 LYS 174 245 245 LYS LYS E . n 
C 1 175 LYS 175 246 246 LYS LYS E . n 
C 1 176 THR 176 247 247 THR THR E . n 
C 1 177 SER 177 248 248 SER SER E . n 
C 1 178 VAL 178 249 249 VAL VAL E . n 
C 1 179 SER 179 250 250 SER SER E . n 
C 1 180 ALA 180 251 251 ALA ALA E . n 
C 1 181 SER 181 252 252 SER SER E . n 
C 1 182 GLN 182 253 253 GLN GLN E . n 
C 1 183 TRP 183 254 254 TRP TRP E . n 
C 1 184 TYR 184 255 255 TYR TYR E . n 
C 1 185 THR 185 256 256 THR THR E . n 
C 1 186 LYS 186 257 257 LYS LYS E . n 
C 1 187 HIS 187 258 258 HIS HIS E . n 
C 1 188 HIS 188 259 259 HIS HIS E . n 
C 1 189 ASN 189 260 260 ASN ASN E . n 
C 1 190 ASN 190 261 261 ASN ASN E . n 
C 1 191 ALA 191 262 262 ALA ALA E . n 
C 1 192 THR 192 263 263 THR THR E . n 
C 1 193 THR 193 264 264 THR THR E . n 
C 1 194 SER 194 265 265 SER SER E . n 
C 1 195 ILE 195 266 266 ILE ILE E . n 
C 1 196 THR 196 267 267 THR THR E . n 
C 1 197 SER 197 268 268 SER SER E . n 
C 1 198 ILE 198 269 269 ILE ILE E . n 
C 1 199 LEU 199 270 270 LEU LEU E . n 
C 1 200 PRO 200 271 271 PRO PRO E . n 
C 1 201 VAL 201 272 272 VAL VAL E . n 
C 1 202 VAL 202 273 273 VAL VAL E . n 
C 1 203 ALA 203 274 274 ALA ALA E . n 
C 1 204 LYS 204 275 275 LYS LYS E . n 
C 1 205 ASP 205 276 276 ASP ASP E . n 
C 1 206 TRP 206 277 277 TRP TRP E . n 
C 1 207 ILE 207 278 278 ILE ILE E . n 
C 1 208 GLU 208 279 279 GLU GLU E . n 
C 1 209 GLY 209 280 280 GLY GLY E . n 
C 1 210 TYR 210 281 281 TYR TYR E . n 
C 1 211 GLY 211 282 282 GLY GLY E . n 
C 1 212 TYR 212 283 283 TYR TYR E . n 
C 1 213 GLN 213 284 284 GLN GLN E . n 
C 1 214 CYS 214 285 285 CYS CYS E . n 
C 1 215 ILE 215 286 286 ILE ILE E . n 
C 1 216 VAL 216 287 287 VAL VAL E . n 
C 1 217 ASP 217 288 288 ASP ASP E . n 
C 1 218 HIS 218 289 289 HIS HIS E . n 
C 1 219 PRO 219 290 290 PRO PRO E . n 
C 1 220 ASP 220 291 291 ASP ASP E . n 
C 1 221 PHE 221 292 292 PHE PHE E . n 
C 1 222 PRO 222 293 293 PRO PRO E . n 
C 1 223 LYS 223 294 294 LYS LYS E . n 
C 1 224 PRO 224 295 295 PRO PRO E . n 
C 1 225 ILE 225 296 296 ILE ILE E . n 
C 1 226 VAL 226 297 297 VAL VAL E . n 
C 1 227 ARG 227 298 298 ARG ARG E . n 
C 1 228 SER 228 299 299 SER SER E . n 
C 1 229 ILE 229 300 300 ILE ILE E . n 
C 1 230 THR 230 301 301 THR THR E . n 
C 1 231 LYS 231 302 302 LYS LYS E . n 
C 1 232 THR 232 303 303 THR THR E . n 
C 1 233 PRO 233 304 304 PRO PRO E . n 
C 1 234 GLY 234 305 305 GLY GLY E . n 
C 1 235 GLN 235 306 306 GLN GLN E . n 
C 1 236 ARG 236 307 307 ARG ARG E . n 
C 1 237 SER 237 308 308 SER SER E . n 
C 1 238 ALA 238 309 309 ALA ALA E . n 
C 1 239 PRO 239 310 310 PRO PRO E . n 
C 1 240 GLU 240 311 311 GLU GLU E . n 
C 1 241 VAL 241 312 312 VAL VAL E . n 
C 1 242 TYR 242 313 313 TYR TYR E . n 
C 1 243 VAL 243 314 314 VAL VAL E . n 
C 1 244 PHE 244 315 315 PHE PHE E . n 
C 1 245 PRO 245 316 316 PRO PRO E . n 
C 1 246 PRO 246 317 317 PRO PRO E . n 
C 1 247 PRO 247 318 318 PRO PRO E . n 
C 1 248 GLU 248 319 319 GLU GLU E . n 
C 1 249 GLU 249 320 320 GLU GLU E . n 
C 1 250 GLU 250 321 321 GLU GLU E . n 
C 1 251 SER 251 322 322 SER SER E . n 
C 1 252 GLU 252 323 323 GLU GLU E . n 
C 1 253 ASP 253 324 324 ASP ASP E . n 
C 1 254 LYS 254 325 325 LYS LYS E . n 
C 1 255 ARG 255 326 326 ARG ARG E . n 
C 1 256 THR 256 327 327 THR THR E . n 
C 1 257 LEU 257 328 328 LEU LEU E . n 
C 1 258 THR 258 329 329 THR THR E . n 
C 1 259 CYS 259 330 330 CYS CYS E . n 
C 1 260 LEU 260 331 331 LEU LEU E . n 
C 1 261 ILE 261 332 332 ILE ILE E . n 
C 1 262 GLN 262 333 333 GLN GLN E . n 
C 1 263 ASN 263 334 334 ASN ASN E . n 
C 1 264 PHE 264 335 335 PHE PHE E . n 
C 1 265 PHE 265 336 336 PHE PHE E . n 
C 1 266 PRO 266 337 337 PRO PRO E . n 
C 1 267 GLU 267 338 338 GLU GLU E . n 
C 1 268 ASP 268 339 339 ASP ASP E . n 
C 1 269 ILE 269 340 340 ILE ILE E . n 
C 1 270 SER 270 341 341 SER SER E . n 
C 1 271 VAL 271 342 342 VAL VAL E . n 
C 1 272 GLN 272 343 343 GLN GLN E . n 
C 1 273 TRP 273 344 344 TRP TRP E . n 
C 1 274 LEU 274 345 345 LEU LEU E . n 
C 1 275 GLY 275 346 346 GLY GLY E . n 
C 1 276 ASP 276 347 347 ASP ASP E . n 
C 1 277 GLY 277 348 348 GLY GLY E . n 
C 1 278 LYS 278 349 349 LYS LYS E . n 
C 1 279 LEU 279 350 350 LEU LEU E . n 
C 1 280 ILE 280 351 351 ILE ILE E . n 
C 1 281 SER 281 352 352 SER SER E . n 
C 1 282 ASN 282 353 353 ASN ASN E . n 
C 1 283 SER 283 354 354 SER SER E . n 
C 1 284 GLN 284 355 355 GLN GLN E . n 
C 1 285 HIS 285 356 356 HIS HIS E . n 
C 1 286 SER 286 357 357 SER SER E . n 
C 1 287 THR 287 358 358 THR THR E . n 
C 1 288 THR 288 359 359 THR THR E . n 
C 1 289 THR 289 360 360 THR THR E . n 
C 1 290 PRO 290 361 361 PRO PRO E . n 
C 1 291 LEU 291 362 362 LEU LEU E . n 
C 1 292 LYS 292 363 363 LYS LYS E . n 
C 1 293 SER 293 364 364 SER SER E . n 
C 1 294 ASN 294 365 365 ASN ASN E . n 
C 1 295 GLY 295 366 366 GLY GLY E . n 
C 1 296 SER 296 367 367 SER SER E . n 
C 1 297 ASN 297 368 368 ASN ASN E . n 
C 1 298 GLN 298 369 369 GLN GLN E . n 
C 1 299 GLY 299 370 370 GLY GLY E . n 
C 1 300 PHE 300 371 371 PHE PHE E . n 
C 1 301 PHE 301 372 372 PHE PHE E . n 
C 1 302 ILE 302 373 373 ILE ILE E . n 
C 1 303 PHE 303 374 374 PHE PHE E . n 
C 1 304 SER 304 375 375 SER SER E . n 
C 1 305 ARG 305 376 376 ARG ARG E . n 
C 1 306 LEU 306 377 377 LEU LEU E . n 
C 1 307 GLU 307 378 378 GLU GLU E . n 
C 1 308 VAL 308 379 379 VAL VAL E . n 
C 1 309 ALA 309 380 380 ALA ALA E . n 
C 1 310 LYS 310 381 381 LYS LYS E . n 
C 1 311 THR 311 382 382 THR THR E . n 
C 1 312 LEU 312 383 383 LEU LEU E . n 
C 1 313 TRP 313 384 384 TRP TRP E . n 
C 1 314 THR 314 385 385 THR THR E . n 
C 1 315 GLN 315 386 386 GLN GLN E . n 
C 1 316 ARG 316 387 387 ARG ARG E . n 
C 1 317 LYS 317 388 388 LYS LYS E . n 
C 1 318 GLN 318 389 389 GLN GLN E . n 
C 1 319 PHE 319 390 390 PHE PHE E . n 
C 1 320 THR 320 391 391 THR THR E . n 
C 1 321 CYS 321 392 392 CYS CYS E . n 
C 1 322 GLN 322 393 393 GLN GLN E . n 
C 1 323 VAL 323 394 394 VAL VAL E . n 
C 1 324 ILE 324 395 395 ILE ILE E . n 
C 1 325 HIS 325 396 396 HIS HIS E . n 
C 1 326 GLU 326 397 397 GLU GLU E . n 
C 1 327 ALA 327 398 398 ALA ALA E . n 
C 1 328 LEU 328 399 399 LEU LEU E . n 
C 1 329 GLN 329 400 400 GLN GLN E . n 
C 1 330 LYS 330 401 401 LYS LYS E . n 
C 1 331 PRO 331 402 402 PRO PRO E . n 
C 1 332 ARG 332 403 403 ARG ARG E . n 
C 1 333 LYS 333 404 404 LYS LYS E . n 
C 1 334 LEU 334 405 405 LEU LEU E . n 
C 1 335 GLU 335 406 406 GLU GLU E . n 
C 1 336 LYS 336 407 407 LYS LYS E . n 
C 1 337 THR 337 408 408 THR THR E . n 
C 1 338 ILE 338 409 409 ILE ILE E . n 
C 1 339 SER 339 410 410 SER SER E . n 
C 1 340 THR 340 411 411 THR THR E . n 
C 1 341 SER 341 412 412 SER SER E . n 
C 1 342 LEU 342 413 413 LEU LEU E . n 
C 1 343 GLY 343 414 414 GLY GLY E . n 
C 1 344 ASN 344 415 ?   ?   ?   E . n 
C 1 345 THR 345 416 ?   ?   ?   E . n 
C 1 346 SER 346 417 ?   ?   ?   E . n 
C 1 347 LEU 347 418 ?   ?   ?   E . n 
C 1 348 ARG 348 419 ?   ?   ?   E . n 
C 1 349 PRO 349 420 ?   ?   ?   E . n 
C 1 350 SER 350 421 ?   ?   ?   E . n 
C 1 351 HIS 351 422 ?   ?   ?   E . n 
C 1 352 HIS 352 423 ?   ?   ?   E . n 
C 1 353 HIS 353 424 ?   ?   ?   E . n 
C 1 354 HIS 354 425 ?   ?   ?   E . n 
C 1 355 HIS 355 426 ?   ?   ?   E . n 
C 1 356 HIS 356 427 ?   ?   ?   E . n 
# 
loop_
_pdbx_branch_scheme.asym_id 
_pdbx_branch_scheme.entity_id 
_pdbx_branch_scheme.mon_id 
_pdbx_branch_scheme.num 
_pdbx_branch_scheme.pdb_asym_id 
_pdbx_branch_scheme.pdb_mon_id 
_pdbx_branch_scheme.pdb_seq_num 
_pdbx_branch_scheme.auth_asym_id 
_pdbx_branch_scheme.auth_mon_id 
_pdbx_branch_scheme.auth_seq_num 
_pdbx_branch_scheme.hetero 
D 3 NAG 1 x NAG 1 x NAG 414 n 
D 3 NAG 2 x NAG 2 x NAG 415 n 
D 3 BMA 3 x BMA 3 x BMA 417 n 
D 3 MAN 4 x MAN 4 x MAN 419 n 
D 3 MAN 5 x MAN 5 x MAN 418 n 
E 4 NAG 1 y NAG 1 y NAG 197 n 
E 4 NAG 2 y NAG 2 y NAG 198 n 
E 4 BMA 3 y BMA 3 y BMA 199 n 
F 3 NAG 1 z NAG 1 z NAG 416 n 
F 3 NAG 2 z NAG 2 z NAG 417 n 
F 3 BMA 3 z BMA 3 z BMA 418 n 
F 3 MAN 4 z MAN 4 z MAN 419 n 
F 3 MAN 5 z MAN 5 z MAN 420 n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
G 5 NAG 1 501 416 NAG NAG F . 
H 5 NAG 1 301 196 NAG NAG A . 
I 5 NAG 1 302 200 NAG NAG A . 
J 5 NAG 1 303 203 NAG NAG A . 
K 5 NAG 1 501 415 NAG NAG E . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8K7S 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8K7S 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8K7S 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 8K7S 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.002 ? 6811 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.495 ? 9283 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 8.650 ? 2690 ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.043 ? 1097 ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.005 ? 1157 ? f_plane_restr      ? ? 
# 
_struct.entry_id                     8K7S 
_struct.title                        'Human Fc epsilon RI in complex with mIgE Fc (TMD disordered)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8K7S 
_struct_keywords.text            'IgE, high-affinity IgE receptor, allergy, IMMUNE SYSTEM' 
_struct_keywords.pdbx_keywords   'IMMUNE SYSTEM' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 1 ? 
D N N 3 ? 
E N N 4 ? 
F N N 3 ? 
G N N 5 ? 
H N N 5 ? 
I N N 5 ? 
J N N 5 ? 
K N N 5 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 PDB 8K7S 8K7S ? 1 ? 1 
2 PDB 8K7S 8K7S ? 2 ? 1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8K7S F 1 ? 356 ? 8K7S 72 ? 427 ? 72 427 
2 2 8K7S A 1 ? 280 ? 8K7S 1  ? 280 ? 1  280 
3 1 8K7S E 1 ? 356 ? 8K7S 72 ? 427 ? 72 427 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 97  ? MET A 102 ? THR F 168 MET F 173 1 ? 6 
HELX_P HELX_P2  AA2 SER A 141 ? GLN A 147 ? SER F 212 GLN F 218 1 ? 7 
HELX_P HELX_P3  AA3 VAL A 202 ? GLY A 209 ? VAL F 273 GLY F 280 1 ? 8 
HELX_P HELX_P4  AA4 ALA A 309 ? GLN A 315 ? ALA F 380 GLN F 386 1 ? 7 
HELX_P HELX_P5  AA5 LYS B 84  ? SER B 88  ? LYS A 84  SER A 88  5 ? 5 
HELX_P HELX_P6  AA6 GLY B 134 ? TRP B 138 ? GLY A 134 TRP A 138 5 ? 5 
HELX_P HELX_P7  AA7 THR B 167 ? SER B 171 ? THR A 167 SER A 171 5 ? 5 
HELX_P HELX_P8  AA8 GLU C 98  ? MET C 102 ? GLU E 169 MET E 173 1 ? 5 
HELX_P HELX_P9  AA9 VAL C 202 ? GLU C 208 ? VAL E 273 GLU E 279 1 ? 7 
HELX_P HELX_P10 AB1 SER C 281 ? HIS C 285 ? SER E 352 HIS E 356 5 ? 5 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1  disulf ?    ? A CYS 37  SG  ? ? ? 1_555 C CYS 125 SG ? ? F CYS 108 E CYS 196 1_555 ? ? ? ? ? ? ? 2.032 ? ?               
disulf2  disulf ?    ? A CYS 50  SG  ? ? ? 1_555 A CYS 109 SG ? ? F CYS 121 F CYS 180 1_555 ? ? ? ? ? ? ? 2.033 ? ?               
disulf3  disulf ?    ? A CYS 125 SG  ? ? ? 1_555 C CYS 37  SG ? ? F CYS 196 E CYS 108 1_555 ? ? ? ? ? ? ? 2.031 ? ?               
disulf4  disulf ?    ? A CYS 155 SG  ? ? ? 1_555 A CYS 214 SG ? ? F CYS 226 F CYS 285 1_555 ? ? ? ? ? ? ? 2.033 ? ?               
disulf5  disulf ?    ? A CYS 259 SG  ? ? ? 1_555 A CYS 321 SG ? ? F CYS 330 F CYS 392 1_555 ? ? ? ? ? ? ? 2.034 ? ?               
disulf6  disulf ?    ? B CYS 51  SG  ? ? ? 1_555 B CYS 93  SG ? ? A CYS 51  A CYS 93  1_555 ? ? ? ? ? ? ? 2.031 ? ?               
disulf7  disulf ?    ? B CYS 132 SG  ? ? ? 1_555 B CYS 176 SG ? ? A CYS 132 A CYS 176 1_555 ? ? ? ? ? ? ? 2.032 ? ?               
disulf8  disulf ?    ? C CYS 50  SG  ? ? ? 1_555 C CYS 109 SG ? ? E CYS 121 E CYS 180 1_555 ? ? ? ? ? ? ? 2.034 ? ?               
disulf9  disulf ?    ? C CYS 155 SG  ? ? ? 1_555 C CYS 214 SG ? ? E CYS 226 E CYS 285 1_555 ? ? ? ? ? ? ? 2.034 ? ?               
disulf10 disulf ?    ? C CYS 259 SG  ? ? ? 1_555 C CYS 321 SG ? ? E CYS 330 E CYS 392 1_555 ? ? ? ? ? ? ? 2.036 ? ?               
covale1  covale one  ? A ASN 167 ND2 ? ? ? 1_555 G NAG .   C1 ? ? F ASN 238 F NAG 501 1_555 ? ? ? ? ? ? ? 1.440 ? N-Glycosylation 
covale2  covale one  ? A ASN 190 ND2 ? ? ? 1_555 D NAG .   C1 ? ? F ASN 261 x NAG 1   1_555 ? ? ? ? ? ? ? 1.442 ? N-Glycosylation 
covale3  covale one  ? B ASN 46  ND2 ? ? ? 1_555 I NAG .   C1 ? ? A ASN 46  A NAG 302 1_555 ? ? ? ? ? ? ? 1.441 ? N-Glycosylation 
covale4  covale one  ? B ASN 67  ND2 ? ? ? 1_555 E NAG .   C1 ? ? A ASN 67  y NAG 1   1_555 ? ? ? ? ? ? ? 1.441 ? N-Glycosylation 
covale5  covale one  ? B ASN 160 ND2 ? ? ? 1_555 H NAG .   C1 ? ? A ASN 160 A NAG 301 1_555 ? ? ? ? ? ? ? 1.440 ? N-Glycosylation 
covale6  covale one  ? B ASN 191 ND2 ? ? ? 1_555 J NAG .   C1 ? ? A ASN 191 A NAG 303 1_555 ? ? ? ? ? ? ? 1.441 ? N-Glycosylation 
covale7  covale one  ? C ASN 167 ND2 ? ? ? 1_555 K NAG .   C1 ? ? E ASN 238 E NAG 501 1_555 ? ? ? ? ? ? ? 1.442 ? N-Glycosylation 
covale8  covale one  ? C ASN 190 ND2 ? ? ? 1_555 F NAG .   C1 ? ? E ASN 261 z NAG 1   1_555 ? ? ? ? ? ? ? 1.442 ? N-Glycosylation 
covale9  covale both ? D NAG .   O4  ? ? ? 1_555 D NAG .   C1 ? ? x NAG 1   x NAG 2   1_555 ? ? ? ? ? ? ? 1.442 ? ?               
covale10 covale both ? D NAG .   O4  ? ? ? 1_555 D BMA .   C1 ? ? x NAG 2   x BMA 3   1_555 ? ? ? ? ? ? ? 1.444 ? ?               
covale11 covale both ? D BMA .   O3  ? ? ? 1_555 D MAN .   C1 ? ? x BMA 3   x MAN 4   1_555 ? ? ? ? ? ? ? 1.445 ? ?               
covale12 covale both ? D BMA .   O6  ? ? ? 1_555 D MAN .   C1 ? ? x BMA 3   x MAN 5   1_555 ? ? ? ? ? ? ? 1.446 ? ?               
covale13 covale both ? E NAG .   O4  ? ? ? 1_555 E NAG .   C1 ? ? y NAG 1   y NAG 2   1_555 ? ? ? ? ? ? ? 1.442 ? ?               
covale14 covale both ? E NAG .   O4  ? ? ? 1_555 E BMA .   C1 ? ? y NAG 2   y BMA 3   1_555 ? ? ? ? ? ? ? 1.444 ? ?               
covale15 covale both ? F NAG .   O4  ? ? ? 1_555 F NAG .   C1 ? ? z NAG 1   z NAG 2   1_555 ? ? ? ? ? ? ? 1.443 ? ?               
covale16 covale both ? F NAG .   O4  ? ? ? 1_555 F BMA .   C1 ? ? z NAG 2   z BMA 3   1_555 ? ? ? ? ? ? ? 1.445 ? ?               
covale17 covale both ? F BMA .   O3  ? ? ? 1_555 F MAN .   C1 ? ? z BMA 3   z MAN 4   1_555 ? ? ? ? ? ? ? 1.446 ? ?               
covale18 covale both ? F BMA .   O6  ? ? ? 1_555 F MAN .   C1 ? ? z BMA 3   z MAN 5   1_555 ? ? ? ? ? ? ? 1.447 ? ?               
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1  NAG D .   ? ASN A 190 ? NAG x 1   ? 1_555 ASN F 261 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2  NAG E .   ? ASN B 67  ? NAG y 1   ? 1_555 ASN A 67  ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
3  NAG F .   ? ASN C 190 ? NAG z 1   ? 1_555 ASN E 261 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
4  NAG G .   ? ASN A 167 ? NAG F 501 ? 1_555 ASN F 238 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
5  NAG H .   ? ASN B 160 ? NAG A 301 ? 1_555 ASN A 160 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
6  NAG I .   ? ASN B 46  ? NAG A 302 ? 1_555 ASN A 46  ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
7  NAG J .   ? ASN B 191 ? NAG A 303 ? 1_555 ASN A 191 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
8  NAG K .   ? ASN C 167 ? NAG E 501 ? 1_555 ASN E 238 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
9  CYS A 37  ? CYS C 125 ? CYS F 108 ? 1_555 CYS E 196 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
10 CYS A 50  ? CYS A 109 ? CYS F 121 ? 1_555 CYS F 180 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
11 CYS A 125 ? CYS C 37  ? CYS F 196 ? 1_555 CYS E 108 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
12 CYS A 155 ? CYS A 214 ? CYS F 226 ? 1_555 CYS F 285 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
13 CYS A 259 ? CYS A 321 ? CYS F 330 ? 1_555 CYS F 392 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
14 CYS B 51  ? CYS B 93  ? CYS A 51  ? 1_555 CYS A 93  ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
15 CYS B 132 ? CYS B 176 ? CYS A 132 ? 1_555 CYS A 176 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
16 CYS C 50  ? CYS C 109 ? CYS E 121 ? 1_555 CYS E 180 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
17 CYS C 155 ? CYS C 214 ? CYS E 226 ? 1_555 CYS E 285 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
18 CYS C 259 ? CYS C 321 ? CYS E 330 ? 1_555 CYS E 392 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 PHE 265 A . ? PHE 336 F PRO 266 A ? PRO 337 F 1 1.00  
2 LYS 330 A . ? LYS 401 F PRO 331 A ? PRO 402 F 1 -0.91 
3 PHE 265 C . ? PHE 336 E PRO 266 C ? PRO 337 E 1 1.63  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 8 ? 
AA2 ? 3 ? 
AA3 ? 4 ? 
AA4 ? 3 ? 
AA5 ? 4 ? 
AA6 ? 4 ? 
AA7 ? 3 ? 
AA8 ? 4 ? 
AA9 ? 3 ? 
AB1 ? 2 ? 
AB2 ? 4 ? 
AB3 ? 3 ? 
AB4 ? 4 ? 
AB5 ? 3 ? 
AB6 ? 4 ? 
AB7 ? 4 ? 
AB8 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA1 7 8 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
AA8 3 4 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AA9 2 3 ? anti-parallel 
AB1 1 2 ? parallel      
AB2 1 2 ? anti-parallel 
AB2 2 3 ? anti-parallel 
AB2 3 4 ? anti-parallel 
AB3 1 2 ? anti-parallel 
AB3 2 3 ? anti-parallel 
AB4 1 2 ? anti-parallel 
AB4 2 3 ? anti-parallel 
AB4 3 4 ? anti-parallel 
AB5 1 2 ? anti-parallel 
AB5 2 3 ? anti-parallel 
AB6 1 2 ? anti-parallel 
AB6 2 3 ? anti-parallel 
AB6 3 4 ? anti-parallel 
AB7 1 2 ? anti-parallel 
AB7 2 3 ? anti-parallel 
AB7 3 4 ? anti-parallel 
AB8 1 2 ? anti-parallel 
AB8 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 79  ? GLU A 83  ? VAL F 150 GLU F 154 
AA1 2 ALA A 88  ? ILE A 96  ? ALA F 159 ILE F 167 
AA1 3 ILE A 46  ? TYR A 53  ? ILE F 117 TYR F 124 
AA1 4 THR A 29  ? SER A 35  ? THR F 100 SER F 106 
AA1 5 THR C 29  ? HIS C 34  ? THR E 100 HIS E 105 
AA1 6 THR C 45  ? TYR C 53  ? THR E 116 TYR E 124 
AA1 7 LEU C 87  ? THR C 97  ? LEU E 158 THR E 168 
AA1 8 ALA C 76  ? GLU C 84  ? ALA E 147 GLU E 155 
AA2 1 SER A 61  ? LEU A 65  ? SER F 132 LEU F 136 
AA2 2 PHE A 107 ? SER A 113 ? PHE F 178 SER F 184 
AA2 3 VAL A 116 ? THR A 122 ? VAL F 187 THR F 193 
AA3 1 ILE A 134 ? ILE A 138 ? ILE F 205 ILE F 209 
AA3 2 LYS A 152 ? LEU A 160 ? LYS F 223 LEU F 231 
AA3 3 THR A 193 ? PRO A 200 ? THR F 264 PRO F 271 
AA3 4 TYR A 184 ? HIS A 187 ? TYR F 255 HIS F 258 
AA4 1 ASN A 167 ? ASN A 171 ? ASN F 238 ASN F 242 
AA4 2 TYR A 212 ? ASP A 217 ? TYR F 283 ASP F 288 
AA4 3 ILE A 225 ? ILE A 229 ? ILE F 296 ILE F 300 
AA5 1 GLU A 240 ? PHE A 244 ? GLU F 311 PHE F 315 
AA5 2 LEU A 257 ? GLN A 262 ? LEU F 328 GLN F 333 
AA5 3 ILE A 302 ? LEU A 306 ? ILE F 373 LEU F 377 
AA5 4 HIS A 285 ? SER A 286 ? HIS F 356 SER F 357 
AA6 1 LYS A 278 ? LEU A 279 ? LYS F 349 LEU F 350 
AA6 2 SER A 270 ? GLY A 275 ? SER F 341 GLY F 346 
AA6 3 PHE A 319 ? ILE A 324 ? PHE F 390 ILE F 395 
AA6 4 LEU A 334 ? ILE A 338 ? LEU F 405 ILE F 409 
AA7 1 LYS B 31  ? LEU B 34  ? LYS A 31  LEU A 34  
AA7 2 VAL B 47  ? ASN B 52  ? VAL A 47  ASN A 52  
AA7 3 SER B 77  ? ILE B 80  ? SER A 77  ILE A 80  
AA8 1 SER B 69  ? LEU B 70  ? SER A 69  LEU A 70  
AA8 2 LYS B 63  ? HIS B 66  ? LYS A 63  HIS A 66  
AA8 3 GLY B 89  ? GLN B 94  ? GLY A 89  GLN A 94  
AA8 4 VAL B 104 ? LEU B 106 ? VAL A 104 LEU A 106 
AA9 1 GLN B 116 ? ALA B 117 ? GLN A 116 ALA A 117 
AA9 2 LEU B 128 ? ARG B 131 ? LEU A 128 ARG A 131 
AA9 3 ILE B 161 ? ILE B 163 ? ILE A 161 ILE A 163 
AB1 1 VAL B 121 ? VAL B 122 ? VAL A 121 VAL A 122 
AB1 2 THR B 193 ? VAL B 194 ? THR A 193 VAL A 194 
AB2 1 GLU B 150 ? GLU B 157 ? GLU A 150 GLU A 157 
AB2 2 TYR B 141 ? LYS B 147 ? TYR A 141 LYS A 147 
AB2 3 TYR B 174 ? VAL B 180 ? TYR A 174 VAL A 180 
AB2 4 LEU B 183 ? GLU B 186 ? LEU A 183 GLU A 186 
AB3 1 VAL C 62  ? MET C 66  ? VAL E 133 MET E 137 
AB3 2 PHE C 107 ? SER C 113 ? PHE E 178 SER E 184 
AB3 3 VAL C 116 ? HIS C 121 ? VAL E 187 HIS E 192 
AB4 1 ILE C 134 ? ILE C 138 ? ILE E 205 ILE E 209 
AB4 2 LYS C 152 ? LEU C 160 ? LYS E 223 LEU E 231 
AB4 3 THR C 193 ? PRO C 200 ? THR E 264 PRO E 271 
AB4 4 GLN C 182 ? HIS C 187 ? GLN E 253 HIS E 258 
AB5 1 ASN C 167 ? GLU C 173 ? ASN E 238 GLU E 244 
AB5 2 GLY C 211 ? ASP C 217 ? GLY E 282 ASP E 288 
AB5 3 ILE C 225 ? ILE C 229 ? ILE E 296 ILE E 300 
AB6 1 GLU C 240 ? PHE C 244 ? GLU E 311 PHE E 315 
AB6 2 LYS C 254 ? PHE C 264 ? LYS E 325 PHE E 335 
AB6 3 PHE C 300 ? ALA C 309 ? PHE E 371 ALA E 380 
AB6 4 SER C 286 ? THR C 287 ? SER E 357 THR E 358 
AB7 1 GLU C 240 ? PHE C 244 ? GLU E 311 PHE E 315 
AB7 2 LYS C 254 ? PHE C 264 ? LYS E 325 PHE E 335 
AB7 3 PHE C 300 ? ALA C 309 ? PHE E 371 ALA E 380 
AB7 4 LEU C 291 ? LYS C 292 ? LEU E 362 LYS E 363 
AB8 1 ILE C 269 ? TRP C 273 ? ILE E 340 TRP E 344 
AB8 2 THR C 320 ? HIS C 325 ? THR E 391 HIS E 396 
AB8 3 LEU C 334 ? THR C 337 ? LEU E 405 THR E 408 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE A 81  ? N ILE F 152 O SER A 89  ? O SER F 160 
AA1 2 3 O ILE A 96  ? O ILE F 167 N ILE A 46  ? N ILE F 117 
AA1 3 4 O TYR A 49  ? O TYR F 120 N LEU A 33  ? N LEU F 104 
AA1 4 5 N HIS A 34  ? N HIS F 105 O HIS C 34  ? O HIS E 105 
AA1 5 6 N GLU C 31  ? N GLU E 102 O PHE C 51  ? O PHE E 122 
AA1 6 7 N ILE C 46  ? N ILE E 117 O ILE C 96  ? O ILE E 167 
AA1 7 8 O SER C 89  ? O SER E 160 N LYS C 82  ? N LYS E 153 
AA2 1 2 N SER A 63  ? N SER F 134 O LYS A 110 ? O LYS F 181 
AA2 2 3 N VAL A 111 ? N VAL F 182 O TYR A 118 ? O TYR F 189 
AA3 1 2 N ILE A 138 ? N ILE F 209 O THR A 154 ? O THR F 225 
AA3 2 3 N CYS A 155 ? N CYS F 226 O SER A 197 ? O SER F 268 
AA3 3 4 O THR A 196 ? O THR F 267 N TYR A 184 ? N TYR F 255 
AA4 1 2 N ASN A 167 ? N ASN F 238 O ASP A 217 ? O ASP F 288 
AA4 2 3 N CYS A 214 ? N CYS F 285 O ARG A 227 ? O ARG F 298 
AA5 1 2 N GLU A 240 ? N GLU F 311 O GLN A 262 ? O GLN F 333 
AA5 2 3 N CYS A 259 ? N CYS F 330 O SER A 304 ? O SER F 375 
AA5 3 4 O ARG A 305 ? O ARG F 376 N SER A 286 ? N SER F 357 
AA6 1 2 O LYS A 278 ? O LYS F 349 N GLY A 275 ? N GLY F 346 
AA6 2 3 N GLN A 272 ? N GLN F 343 O GLN A 322 ? O GLN F 393 
AA6 3 4 N CYS A 321 ? N CYS F 392 O LYS A 336 ? O LYS F 407 
AA7 1 2 N LYS B 31  ? N LYS A 31  O ASN B 52  ? O ASN A 52  
AA7 2 3 N LEU B 49  ? N LEU A 49  O LEU B 78  ? O LEU A 78  
AA8 1 2 O SER B 69  ? O SER A 69  N HIS B 66  ? N HIS A 66  
AA8 2 3 N PHE B 65  ? N PHE A 65  O LYS B 92  ? O LYS A 92  
AA8 3 4 N GLY B 89  ? N GLY A 89  O LEU B 106 ? O LEU A 106 
AA9 1 2 N GLN B 116 ? N GLN A 116 O ARG B 131 ? O ARG A 131 
AA9 2 3 N LEU B 130 ? N LEU A 130 O ILE B 161 ? O ILE A 161 
AB1 1 2 N VAL B 122 ? N VAL A 122 O THR B 193 ? O THR A 193 
AB2 1 2 O GLU B 150 ? O GLU A 150 N LYS B 147 ? N LYS A 147 
AB2 2 3 N TYR B 141 ? N TYR A 141 O LYS B 179 ? O LYS A 179 
AB2 3 4 N GLY B 178 ? N GLY A 178 O TYR B 185 ? O TYR A 185 
AB3 1 2 N LEU C 65  ? N LEU E 136 O THR C 108 ? O THR E 179 
AB3 2 3 N VAL C 111 ? N VAL E 182 O TYR C 118 ? O TYR E 189 
AB4 1 2 N TYR C 136 ? N TYR E 207 O LEU C 156 ? O LEU E 227 
AB4 2 3 N CYS C 155 ? N CYS E 226 O SER C 197 ? O SER E 268 
AB4 3 4 O ILE C 198 ? O ILE E 269 N GLN C 182 ? N GLN E 253 
AB5 1 2 N THR C 169 ? N THR E 240 O ILE C 215 ? O ILE E 286 
AB5 2 3 N CYS C 214 ? N CYS E 285 O ARG C 227 ? O ARG E 298 
AB6 1 2 N TYR C 242 ? N TYR E 313 O LEU C 260 ? O LEU E 331 
AB6 2 3 N ILE C 261 ? N ILE E 332 O ILE C 302 ? O ILE E 373 
AB6 3 4 O ARG C 305 ? O ARG E 376 N SER C 286 ? N SER E 357 
AB7 1 2 N TYR C 242 ? N TYR E 313 O LEU C 260 ? O LEU E 331 
AB7 2 3 N ILE C 261 ? N ILE E 332 O ILE C 302 ? O ILE E 373 
AB7 3 4 O PHE C 301 ? O PHE E 372 N LEU C 291 ? N LEU E 362 
AB8 1 2 N GLN C 272 ? N GLN E 343 O GLN C 322 ? O GLN E 393 
AB8 2 3 N CYS C 321 ? N CYS E 392 O LYS C 336 ? O LYS E 407 
# 
_pdbx_entry_details.entry_id                   8K7S 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASP F 130 ? ? -140.35 24.66   
2  1 HIS F 199 ? ? 62.27   -171.81 
3  1 GLU F 244 ? ? 57.45   -114.09 
4  1 LYS F 246 ? ? 66.35   153.28  
5  1 GLU F 319 ? ? 56.07   -159.80 
6  1 ASN F 334 ? ? 60.15   61.12   
7  1 PRO F 402 ? ? -93.53  44.28   
8  1 PRO A 37  ? ? -66.09  2.04    
9  1 PHE A 57  ? ? 55.93   -159.82 
10 1 GLN A 96  ? ? 58.64   -141.35 
11 1 LEU A 115 ? ? -36.75  127.50  
12 1 THR E 193 ? ? -95.97  -62.64  
13 1 ARG E 194 ? ? 63.18   156.39  
14 1 CYS E 196 ? ? -167.98 62.88   
15 1 PRO E 197 ? ? 23.62   40.42   
16 1 ASP E 198 ? ? 43.78   -143.52 
17 1 GLU E 200 ? ? -55.49  109.70  
18 1 VAL E 204 ? ? 58.48   82.55   
19 1 PRO E 213 ? ? -79.09  45.59   
20 1 TYR E 217 ? ? -106.45 70.66   
21 1 GLN E 218 ? ? -173.93 -109.07 
22 1 ALA E 221 ? ? -160.24 63.48   
23 1 THR E 247 ? ? 61.18   -67.63  
24 1 SER E 248 ? ? 55.52   -159.65 
25 1 GLU E 321 ? ? -121.49 -63.55  
26 1 PRO E 337 ? ? -80.56  -159.36 
27 1 GLN E 355 ? ? -93.27  51.85   
28 1 SER E 367 ? ? 55.47   -101.59 
29 1 SER E 412 ? ? -90.38  57.85   
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8K7S 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    8K7S 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.51 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               166766 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.7 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               'MULTIPLE SOURCES' 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Human Fc epsilon RI in complex with mIgE Fc' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1,2 
# 
_em_imaging.entry_id                        8K7S 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               OTHER 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              8K7S 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8K7S 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 F MET 72  ? A MET 1   
2   1 Y 1 F GLU 73  ? A GLU 2   
3   1 Y 1 F THR 74  ? A THR 3   
4   1 Y 1 F GLY 75  ? A GLY 4   
5   1 Y 1 F LEU 76  ? A LEU 5   
6   1 Y 1 F ARG 77  ? A ARG 6   
7   1 Y 1 F TRP 78  ? A TRP 7   
8   1 Y 1 F LEU 79  ? A LEU 8   
9   1 Y 1 F LEU 80  ? A LEU 9   
10  1 Y 1 F LEU 81  ? A LEU 10  
11  1 Y 1 F VAL 82  ? A VAL 11  
12  1 Y 1 F ALA 83  ? A ALA 12  
13  1 Y 1 F VAL 84  ? A VAL 13  
14  1 Y 1 F LEU 85  ? A LEU 14  
15  1 Y 1 F LYS 86  ? A LYS 15  
16  1 Y 1 F GLY 87  ? A GLY 16  
17  1 Y 1 F VAL 88  ? A VAL 17  
18  1 Y 1 F GLN 89  ? A GLN 18  
19  1 Y 1 F CYS 90  ? A CYS 19  
20  1 Y 1 F VAL 91  ? A VAL 20  
21  1 Y 1 F ARG 92  ? A ARG 21  
22  1 Y 1 F PRO 93  ? A PRO 22  
23  1 Y 1 F VAL 94  ? A VAL 23  
24  1 Y 1 F ASN 95  ? A ASN 24  
25  1 Y 1 F ILE 96  ? A ILE 25  
26  1 Y 1 F THR 97  ? A THR 26  
27  1 Y 1 F GLY 414 ? A GLY 343 
28  1 Y 1 F ASN 415 ? A ASN 344 
29  1 Y 1 F THR 416 ? A THR 345 
30  1 Y 1 F SER 417 ? A SER 346 
31  1 Y 1 F LEU 418 ? A LEU 347 
32  1 Y 1 F ARG 419 ? A ARG 348 
33  1 Y 1 F PRO 420 ? A PRO 349 
34  1 Y 1 F SER 421 ? A SER 350 
35  1 Y 1 F HIS 422 ? A HIS 351 
36  1 Y 1 F HIS 423 ? A HIS 352 
37  1 Y 1 F HIS 424 ? A HIS 353 
38  1 Y 1 F HIS 425 ? A HIS 354 
39  1 Y 1 F HIS 426 ? A HIS 355 
40  1 Y 1 F HIS 427 ? A HIS 356 
41  1 Y 1 A MET 1   ? B MET 1   
42  1 Y 1 A ALA 2   ? B ALA 2   
43  1 Y 1 A PRO 3   ? B PRO 3   
44  1 Y 1 A ALA 4   ? B ALA 4   
45  1 Y 1 A MET 5   ? B MET 5   
46  1 Y 1 A GLU 6   ? B GLU 6   
47  1 Y 1 A SER 7   ? B SER 7   
48  1 Y 1 A PRO 8   ? B PRO 8   
49  1 Y 1 A THR 9   ? B THR 9   
50  1 Y 1 A LEU 10  ? B LEU 10  
51  1 Y 1 A LEU 11  ? B LEU 11  
52  1 Y 1 A CYS 12  ? B CYS 12  
53  1 Y 1 A VAL 13  ? B VAL 13  
54  1 Y 1 A ALA 14  ? B ALA 14  
55  1 Y 1 A LEU 15  ? B LEU 15  
56  1 Y 1 A LEU 16  ? B LEU 16  
57  1 Y 1 A PHE 17  ? B PHE 17  
58  1 Y 1 A PHE 18  ? B PHE 18  
59  1 Y 1 A ALA 19  ? B ALA 19  
60  1 Y 1 A PRO 20  ? B PRO 20  
61  1 Y 1 A ASP 21  ? B ASP 21  
62  1 Y 1 A GLY 22  ? B GLY 22  
63  1 Y 1 A VAL 23  ? B VAL 23  
64  1 Y 1 A LEU 24  ? B LEU 24  
65  1 Y 1 A ALA 25  ? B ALA 25  
66  1 Y 1 A VAL 26  ? B VAL 26  
67  1 Y 1 A PRO 27  ? B PRO 27  
68  1 Y 1 A GLN 28  ? B GLN 28  
69  1 Y 1 A LYS 196 ? B LYS 196 
70  1 Y 1 A ALA 197 ? B ALA 197 
71  1 Y 1 A PRO 198 ? B PRO 198 
72  1 Y 1 A ARG 199 ? B ARG 199 
73  1 Y 1 A GLU 200 ? B GLU 200 
74  1 Y 1 A LYS 201 ? B LYS 201 
75  1 Y 1 A TYR 202 ? B TYR 202 
76  1 Y 1 A TRP 203 ? B TRP 203 
77  1 Y 1 A LEU 204 ? B LEU 204 
78  1 Y 1 A GLN 205 ? B GLN 205 
79  1 Y 1 A PHE 206 ? B PHE 206 
80  1 Y 1 A PHE 207 ? B PHE 207 
81  1 Y 1 A ILE 208 ? B ILE 208 
82  1 Y 1 A PRO 209 ? B PRO 209 
83  1 Y 1 A LEU 210 ? B LEU 210 
84  1 Y 1 A LEU 211 ? B LEU 211 
85  1 Y 1 A VAL 212 ? B VAL 212 
86  1 Y 1 A VAL 213 ? B VAL 213 
87  1 Y 1 A ILE 214 ? B ILE 214 
88  1 Y 1 A LEU 215 ? B LEU 215 
89  1 Y 1 A PHE 216 ? B PHE 216 
90  1 Y 1 A ALA 217 ? B ALA 217 
91  1 Y 1 A VAL 218 ? B VAL 218 
92  1 Y 1 A ASP 219 ? B ASP 219 
93  1 Y 1 A THR 220 ? B THR 220 
94  1 Y 1 A GLY 221 ? B GLY 221 
95  1 Y 1 A LEU 222 ? B LEU 222 
96  1 Y 1 A PHE 223 ? B PHE 223 
97  1 Y 1 A ILE 224 ? B ILE 224 
98  1 Y 1 A SER 225 ? B SER 225 
99  1 Y 1 A THR 226 ? B THR 226 
100 1 Y 1 A GLN 227 ? B GLN 227 
101 1 Y 1 A GLN 228 ? B GLN 228 
102 1 Y 1 A GLN 229 ? B GLN 229 
103 1 Y 1 A VAL 230 ? B VAL 230 
104 1 Y 1 A THR 231 ? B THR 231 
105 1 Y 1 A PHE 232 ? B PHE 232 
106 1 Y 1 A LEU 233 ? B LEU 233 
107 1 Y 1 A LEU 234 ? B LEU 234 
108 1 Y 1 A LYS 235 ? B LYS 235 
109 1 Y 1 A ILE 236 ? B ILE 236 
110 1 Y 1 A LYS 237 ? B LYS 237 
111 1 Y 1 A ARG 238 ? B ARG 238 
112 1 Y 1 A THR 239 ? B THR 239 
113 1 Y 1 A ARG 240 ? B ARG 240 
114 1 Y 1 A LYS 241 ? B LYS 241 
115 1 Y 1 A GLY 242 ? B GLY 242 
116 1 Y 1 A PHE 243 ? B PHE 243 
117 1 Y 1 A ARG 244 ? B ARG 244 
118 1 Y 1 A LEU 245 ? B LEU 245 
119 1 Y 1 A LEU 246 ? B LEU 246 
120 1 Y 1 A ASN 247 ? B ASN 247 
121 1 Y 1 A PRO 248 ? B PRO 248 
122 1 Y 1 A HIS 249 ? B HIS 249 
123 1 Y 1 A PRO 250 ? B PRO 250 
124 1 Y 1 A LYS 251 ? B LYS 251 
125 1 Y 1 A PRO 252 ? B PRO 252 
126 1 Y 1 A ASN 253 ? B ASN 253 
127 1 Y 1 A PRO 254 ? B PRO 254 
128 1 Y 1 A LYS 255 ? B LYS 255 
129 1 Y 1 A ASN 256 ? B ASN 256 
130 1 Y 1 A ASN 257 ? B ASN 257 
131 1 Y 1 A GLU 258 ? B GLU 258 
132 1 Y 1 A ASN 259 ? B ASN 259 
133 1 Y 1 A LEU 260 ? B LEU 260 
134 1 Y 1 A TYR 261 ? B TYR 261 
135 1 Y 1 A PHE 262 ? B PHE 262 
136 1 Y 1 A GLN 263 ? B GLN 263 
137 1 Y 1 A GLY 264 ? B GLY 264 
138 1 Y 1 A ASP 265 ? B ASP 265 
139 1 Y 1 A TYR 266 ? B TYR 266 
140 1 Y 1 A LYS 267 ? B LYS 267 
141 1 Y 1 A ASP 268 ? B ASP 268 
142 1 Y 1 A ASP 269 ? B ASP 269 
143 1 Y 1 A ASP 270 ? B ASP 270 
144 1 Y 1 A ASP 271 ? B ASP 271 
145 1 Y 1 A LYS 272 ? B LYS 272 
146 1 Y 1 A HIS 273 ? B HIS 273 
147 1 Y 1 A HIS 274 ? B HIS 274 
148 1 Y 1 A HIS 275 ? B HIS 275 
149 1 Y 1 A HIS 276 ? B HIS 276 
150 1 Y 1 A HIS 277 ? B HIS 277 
151 1 Y 1 A HIS 278 ? B HIS 278 
152 1 Y 1 A HIS 279 ? B HIS 279 
153 1 Y 1 A HIS 280 ? B HIS 280 
154 1 Y 1 E MET 72  ? C MET 1   
155 1 Y 1 E GLU 73  ? C GLU 2   
156 1 Y 1 E THR 74  ? C THR 3   
157 1 Y 1 E GLY 75  ? C GLY 4   
158 1 Y 1 E LEU 76  ? C LEU 5   
159 1 Y 1 E ARG 77  ? C ARG 6   
160 1 Y 1 E TRP 78  ? C TRP 7   
161 1 Y 1 E LEU 79  ? C LEU 8   
162 1 Y 1 E LEU 80  ? C LEU 9   
163 1 Y 1 E LEU 81  ? C LEU 10  
164 1 Y 1 E VAL 82  ? C VAL 11  
165 1 Y 1 E ALA 83  ? C ALA 12  
166 1 Y 1 E VAL 84  ? C VAL 13  
167 1 Y 1 E LEU 85  ? C LEU 14  
168 1 Y 1 E LYS 86  ? C LYS 15  
169 1 Y 1 E GLY 87  ? C GLY 16  
170 1 Y 1 E VAL 88  ? C VAL 17  
171 1 Y 1 E GLN 89  ? C GLN 18  
172 1 Y 1 E CYS 90  ? C CYS 19  
173 1 Y 1 E VAL 91  ? C VAL 20  
174 1 Y 1 E ARG 92  ? C ARG 21  
175 1 Y 1 E PRO 93  ? C PRO 22  
176 1 Y 1 E VAL 94  ? C VAL 23  
177 1 Y 1 E ASN 95  ? C ASN 24  
178 1 Y 1 E ILE 96  ? C ILE 25  
179 1 Y 1 E THR 97  ? C THR 26  
180 1 Y 1 E ASN 415 ? C ASN 344 
181 1 Y 1 E THR 416 ? C THR 345 
182 1 Y 1 E SER 417 ? C SER 346 
183 1 Y 1 E LEU 418 ? C LEU 347 
184 1 Y 1 E ARG 419 ? C ARG 348 
185 1 Y 1 E PRO 420 ? C PRO 349 
186 1 Y 1 E SER 421 ? C SER 350 
187 1 Y 1 E HIS 422 ? C HIS 351 
188 1 Y 1 E HIS 423 ? C HIS 352 
189 1 Y 1 E HIS 424 ? C HIS 353 
190 1 Y 1 E HIS 425 ? C HIS 354 
191 1 Y 1 E HIS 426 ? C HIS 355 
192 1 Y 1 E HIS 427 ? C HIS 356 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
BMA C1   C N R 74  
BMA C2   C N S 75  
BMA C3   C N S 76  
BMA C4   C N S 77  
BMA C5   C N R 78  
BMA C6   C N N 79  
BMA O1   O N N 80  
BMA O2   O N N 81  
BMA O3   O N N 82  
BMA O4   O N N 83  
BMA O5   O N N 84  
BMA O6   O N N 85  
BMA H1   H N N 86  
BMA H2   H N N 87  
BMA H3   H N N 88  
BMA H4   H N N 89  
BMA H5   H N N 90  
BMA H61  H N N 91  
BMA H62  H N N 92  
BMA HO1  H N N 93  
BMA HO2  H N N 94  
BMA HO3  H N N 95  
BMA HO4  H N N 96  
BMA HO6  H N N 97  
CYS N    N N N 98  
CYS CA   C N R 99  
CYS C    C N N 100 
CYS O    O N N 101 
CYS CB   C N N 102 
CYS SG   S N N 103 
CYS OXT  O N N 104 
CYS H    H N N 105 
CYS H2   H N N 106 
CYS HA   H N N 107 
CYS HB2  H N N 108 
CYS HB3  H N N 109 
CYS HG   H N N 110 
CYS HXT  H N N 111 
GLN N    N N N 112 
GLN CA   C N S 113 
GLN C    C N N 114 
GLN O    O N N 115 
GLN CB   C N N 116 
GLN CG   C N N 117 
GLN CD   C N N 118 
GLN OE1  O N N 119 
GLN NE2  N N N 120 
GLN OXT  O N N 121 
GLN H    H N N 122 
GLN H2   H N N 123 
GLN HA   H N N 124 
GLN HB2  H N N 125 
GLN HB3  H N N 126 
GLN HG2  H N N 127 
GLN HG3  H N N 128 
GLN HE21 H N N 129 
GLN HE22 H N N 130 
GLN HXT  H N N 131 
GLU N    N N N 132 
GLU CA   C N S 133 
GLU C    C N N 134 
GLU O    O N N 135 
GLU CB   C N N 136 
GLU CG   C N N 137 
GLU CD   C N N 138 
GLU OE1  O N N 139 
GLU OE2  O N N 140 
GLU OXT  O N N 141 
GLU H    H N N 142 
GLU H2   H N N 143 
GLU HA   H N N 144 
GLU HB2  H N N 145 
GLU HB3  H N N 146 
GLU HG2  H N N 147 
GLU HG3  H N N 148 
GLU HE2  H N N 149 
GLU HXT  H N N 150 
GLY N    N N N 151 
GLY CA   C N N 152 
GLY C    C N N 153 
GLY O    O N N 154 
GLY OXT  O N N 155 
GLY H    H N N 156 
GLY H2   H N N 157 
GLY HA2  H N N 158 
GLY HA3  H N N 159 
GLY HXT  H N N 160 
HIS N    N N N 161 
HIS CA   C N S 162 
HIS C    C N N 163 
HIS O    O N N 164 
HIS CB   C N N 165 
HIS CG   C Y N 166 
HIS ND1  N Y N 167 
HIS CD2  C Y N 168 
HIS CE1  C Y N 169 
HIS NE2  N Y N 170 
HIS OXT  O N N 171 
HIS H    H N N 172 
HIS H2   H N N 173 
HIS HA   H N N 174 
HIS HB2  H N N 175 
HIS HB3  H N N 176 
HIS HD1  H N N 177 
HIS HD2  H N N 178 
HIS HE1  H N N 179 
HIS HE2  H N N 180 
HIS HXT  H N N 181 
ILE N    N N N 182 
ILE CA   C N S 183 
ILE C    C N N 184 
ILE O    O N N 185 
ILE CB   C N S 186 
ILE CG1  C N N 187 
ILE CG2  C N N 188 
ILE CD1  C N N 189 
ILE OXT  O N N 190 
ILE H    H N N 191 
ILE H2   H N N 192 
ILE HA   H N N 193 
ILE HB   H N N 194 
ILE HG12 H N N 195 
ILE HG13 H N N 196 
ILE HG21 H N N 197 
ILE HG22 H N N 198 
ILE HG23 H N N 199 
ILE HD11 H N N 200 
ILE HD12 H N N 201 
ILE HD13 H N N 202 
ILE HXT  H N N 203 
LEU N    N N N 204 
LEU CA   C N S 205 
LEU C    C N N 206 
LEU O    O N N 207 
LEU CB   C N N 208 
LEU CG   C N N 209 
LEU CD1  C N N 210 
LEU CD2  C N N 211 
LEU OXT  O N N 212 
LEU H    H N N 213 
LEU H2   H N N 214 
LEU HA   H N N 215 
LEU HB2  H N N 216 
LEU HB3  H N N 217 
LEU HG   H N N 218 
LEU HD11 H N N 219 
LEU HD12 H N N 220 
LEU HD13 H N N 221 
LEU HD21 H N N 222 
LEU HD22 H N N 223 
LEU HD23 H N N 224 
LEU HXT  H N N 225 
LYS N    N N N 226 
LYS CA   C N S 227 
LYS C    C N N 228 
LYS O    O N N 229 
LYS CB   C N N 230 
LYS CG   C N N 231 
LYS CD   C N N 232 
LYS CE   C N N 233 
LYS NZ   N N N 234 
LYS OXT  O N N 235 
LYS H    H N N 236 
LYS H2   H N N 237 
LYS HA   H N N 238 
LYS HB2  H N N 239 
LYS HB3  H N N 240 
LYS HG2  H N N 241 
LYS HG3  H N N 242 
LYS HD2  H N N 243 
LYS HD3  H N N 244 
LYS HE2  H N N 245 
LYS HE3  H N N 246 
LYS HZ1  H N N 247 
LYS HZ2  H N N 248 
LYS HZ3  H N N 249 
LYS HXT  H N N 250 
MAN C1   C N S 251 
MAN C2   C N S 252 
MAN C3   C N S 253 
MAN C4   C N S 254 
MAN C5   C N R 255 
MAN C6   C N N 256 
MAN O1   O N N 257 
MAN O2   O N N 258 
MAN O3   O N N 259 
MAN O4   O N N 260 
MAN O5   O N N 261 
MAN O6   O N N 262 
MAN H1   H N N 263 
MAN H2   H N N 264 
MAN H3   H N N 265 
MAN H4   H N N 266 
MAN H5   H N N 267 
MAN H61  H N N 268 
MAN H62  H N N 269 
MAN HO1  H N N 270 
MAN HO2  H N N 271 
MAN HO3  H N N 272 
MAN HO4  H N N 273 
MAN HO6  H N N 274 
MET N    N N N 275 
MET CA   C N S 276 
MET C    C N N 277 
MET O    O N N 278 
MET CB   C N N 279 
MET CG   C N N 280 
MET SD   S N N 281 
MET CE   C N N 282 
MET OXT  O N N 283 
MET H    H N N 284 
MET H2   H N N 285 
MET HA   H N N 286 
MET HB2  H N N 287 
MET HB3  H N N 288 
MET HG2  H N N 289 
MET HG3  H N N 290 
MET HE1  H N N 291 
MET HE2  H N N 292 
MET HE3  H N N 293 
MET HXT  H N N 294 
NAG C1   C N R 295 
NAG C2   C N R 296 
NAG C3   C N R 297 
NAG C4   C N S 298 
NAG C5   C N R 299 
NAG C6   C N N 300 
NAG C7   C N N 301 
NAG C8   C N N 302 
NAG N2   N N N 303 
NAG O1   O N N 304 
NAG O3   O N N 305 
NAG O4   O N N 306 
NAG O5   O N N 307 
NAG O6   O N N 308 
NAG O7   O N N 309 
NAG H1   H N N 310 
NAG H2   H N N 311 
NAG H3   H N N 312 
NAG H4   H N N 313 
NAG H5   H N N 314 
NAG H61  H N N 315 
NAG H62  H N N 316 
NAG H81  H N N 317 
NAG H82  H N N 318 
NAG H83  H N N 319 
NAG HN2  H N N 320 
NAG HO1  H N N 321 
NAG HO3  H N N 322 
NAG HO4  H N N 323 
NAG HO6  H N N 324 
PHE N    N N N 325 
PHE CA   C N S 326 
PHE C    C N N 327 
PHE O    O N N 328 
PHE CB   C N N 329 
PHE CG   C Y N 330 
PHE CD1  C Y N 331 
PHE CD2  C Y N 332 
PHE CE1  C Y N 333 
PHE CE2  C Y N 334 
PHE CZ   C Y N 335 
PHE OXT  O N N 336 
PHE H    H N N 337 
PHE H2   H N N 338 
PHE HA   H N N 339 
PHE HB2  H N N 340 
PHE HB3  H N N 341 
PHE HD1  H N N 342 
PHE HD2  H N N 343 
PHE HE1  H N N 344 
PHE HE2  H N N 345 
PHE HZ   H N N 346 
PHE HXT  H N N 347 
PRO N    N N N 348 
PRO CA   C N S 349 
PRO C    C N N 350 
PRO O    O N N 351 
PRO CB   C N N 352 
PRO CG   C N N 353 
PRO CD   C N N 354 
PRO OXT  O N N 355 
PRO H    H N N 356 
PRO HA   H N N 357 
PRO HB2  H N N 358 
PRO HB3  H N N 359 
PRO HG2  H N N 360 
PRO HG3  H N N 361 
PRO HD2  H N N 362 
PRO HD3  H N N 363 
PRO HXT  H N N 364 
SER N    N N N 365 
SER CA   C N S 366 
SER C    C N N 367 
SER O    O N N 368 
SER CB   C N N 369 
SER OG   O N N 370 
SER OXT  O N N 371 
SER H    H N N 372 
SER H2   H N N 373 
SER HA   H N N 374 
SER HB2  H N N 375 
SER HB3  H N N 376 
SER HG   H N N 377 
SER HXT  H N N 378 
THR N    N N N 379 
THR CA   C N S 380 
THR C    C N N 381 
THR O    O N N 382 
THR CB   C N R 383 
THR OG1  O N N 384 
THR CG2  C N N 385 
THR OXT  O N N 386 
THR H    H N N 387 
THR H2   H N N 388 
THR HA   H N N 389 
THR HB   H N N 390 
THR HG1  H N N 391 
THR HG21 H N N 392 
THR HG22 H N N 393 
THR HG23 H N N 394 
THR HXT  H N N 395 
TRP N    N N N 396 
TRP CA   C N S 397 
TRP C    C N N 398 
TRP O    O N N 399 
TRP CB   C N N 400 
TRP CG   C Y N 401 
TRP CD1  C Y N 402 
TRP CD2  C Y N 403 
TRP NE1  N Y N 404 
TRP CE2  C Y N 405 
TRP CE3  C Y N 406 
TRP CZ2  C Y N 407 
TRP CZ3  C Y N 408 
TRP CH2  C Y N 409 
TRP OXT  O N N 410 
TRP H    H N N 411 
TRP H2   H N N 412 
TRP HA   H N N 413 
TRP HB2  H N N 414 
TRP HB3  H N N 415 
TRP HD1  H N N 416 
TRP HE1  H N N 417 
TRP HE3  H N N 418 
TRP HZ2  H N N 419 
TRP HZ3  H N N 420 
TRP HH2  H N N 421 
TRP HXT  H N N 422 
TYR N    N N N 423 
TYR CA   C N S 424 
TYR C    C N N 425 
TYR O    O N N 426 
TYR CB   C N N 427 
TYR CG   C Y N 428 
TYR CD1  C Y N 429 
TYR CD2  C Y N 430 
TYR CE1  C Y N 431 
TYR CE2  C Y N 432 
TYR CZ   C Y N 433 
TYR OH   O N N 434 
TYR OXT  O N N 435 
TYR H    H N N 436 
TYR H2   H N N 437 
TYR HA   H N N 438 
TYR HB2  H N N 439 
TYR HB3  H N N 440 
TYR HD1  H N N 441 
TYR HD2  H N N 442 
TYR HE1  H N N 443 
TYR HE2  H N N 444 
TYR HH   H N N 445 
TYR HXT  H N N 446 
VAL N    N N N 447 
VAL CA   C N S 448 
VAL C    C N N 449 
VAL O    O N N 450 
VAL CB   C N N 451 
VAL CG1  C N N 452 
VAL CG2  C N N 453 
VAL OXT  O N N 454 
VAL H    H N N 455 
VAL H2   H N N 456 
VAL HA   H N N 457 
VAL HB   H N N 458 
VAL HG11 H N N 459 
VAL HG12 H N N 460 
VAL HG13 H N N 461 
VAL HG21 H N N 462 
VAL HG22 H N N 463 
VAL HG23 H N N 464 
VAL HXT  H N N 465 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
BMA C1  C2   sing N N 70  
BMA C1  O1   sing N N 71  
BMA C1  O5   sing N N 72  
BMA C1  H1   sing N N 73  
BMA C2  C3   sing N N 74  
BMA C2  O2   sing N N 75  
BMA C2  H2   sing N N 76  
BMA C3  C4   sing N N 77  
BMA C3  O3   sing N N 78  
BMA C3  H3   sing N N 79  
BMA C4  C5   sing N N 80  
BMA C4  O4   sing N N 81  
BMA C4  H4   sing N N 82  
BMA C5  C6   sing N N 83  
BMA C5  O5   sing N N 84  
BMA C5  H5   sing N N 85  
BMA C6  O6   sing N N 86  
BMA C6  H61  sing N N 87  
BMA C6  H62  sing N N 88  
BMA O1  HO1  sing N N 89  
BMA O2  HO2  sing N N 90  
BMA O3  HO3  sing N N 91  
BMA O4  HO4  sing N N 92  
BMA O6  HO6  sing N N 93  
CYS N   CA   sing N N 94  
CYS N   H    sing N N 95  
CYS N   H2   sing N N 96  
CYS CA  C    sing N N 97  
CYS CA  CB   sing N N 98  
CYS CA  HA   sing N N 99  
CYS C   O    doub N N 100 
CYS C   OXT  sing N N 101 
CYS CB  SG   sing N N 102 
CYS CB  HB2  sing N N 103 
CYS CB  HB3  sing N N 104 
CYS SG  HG   sing N N 105 
CYS OXT HXT  sing N N 106 
GLN N   CA   sing N N 107 
GLN N   H    sing N N 108 
GLN N   H2   sing N N 109 
GLN CA  C    sing N N 110 
GLN CA  CB   sing N N 111 
GLN CA  HA   sing N N 112 
GLN C   O    doub N N 113 
GLN C   OXT  sing N N 114 
GLN CB  CG   sing N N 115 
GLN CB  HB2  sing N N 116 
GLN CB  HB3  sing N N 117 
GLN CG  CD   sing N N 118 
GLN CG  HG2  sing N N 119 
GLN CG  HG3  sing N N 120 
GLN CD  OE1  doub N N 121 
GLN CD  NE2  sing N N 122 
GLN NE2 HE21 sing N N 123 
GLN NE2 HE22 sing N N 124 
GLN OXT HXT  sing N N 125 
GLU N   CA   sing N N 126 
GLU N   H    sing N N 127 
GLU N   H2   sing N N 128 
GLU CA  C    sing N N 129 
GLU CA  CB   sing N N 130 
GLU CA  HA   sing N N 131 
GLU C   O    doub N N 132 
GLU C   OXT  sing N N 133 
GLU CB  CG   sing N N 134 
GLU CB  HB2  sing N N 135 
GLU CB  HB3  sing N N 136 
GLU CG  CD   sing N N 137 
GLU CG  HG2  sing N N 138 
GLU CG  HG3  sing N N 139 
GLU CD  OE1  doub N N 140 
GLU CD  OE2  sing N N 141 
GLU OE2 HE2  sing N N 142 
GLU OXT HXT  sing N N 143 
GLY N   CA   sing N N 144 
GLY N   H    sing N N 145 
GLY N   H2   sing N N 146 
GLY CA  C    sing N N 147 
GLY CA  HA2  sing N N 148 
GLY CA  HA3  sing N N 149 
GLY C   O    doub N N 150 
GLY C   OXT  sing N N 151 
GLY OXT HXT  sing N N 152 
HIS N   CA   sing N N 153 
HIS N   H    sing N N 154 
HIS N   H2   sing N N 155 
HIS CA  C    sing N N 156 
HIS CA  CB   sing N N 157 
HIS CA  HA   sing N N 158 
HIS C   O    doub N N 159 
HIS C   OXT  sing N N 160 
HIS CB  CG   sing N N 161 
HIS CB  HB2  sing N N 162 
HIS CB  HB3  sing N N 163 
HIS CG  ND1  sing Y N 164 
HIS CG  CD2  doub Y N 165 
HIS ND1 CE1  doub Y N 166 
HIS ND1 HD1  sing N N 167 
HIS CD2 NE2  sing Y N 168 
HIS CD2 HD2  sing N N 169 
HIS CE1 NE2  sing Y N 170 
HIS CE1 HE1  sing N N 171 
HIS NE2 HE2  sing N N 172 
HIS OXT HXT  sing N N 173 
ILE N   CA   sing N N 174 
ILE N   H    sing N N 175 
ILE N   H2   sing N N 176 
ILE CA  C    sing N N 177 
ILE CA  CB   sing N N 178 
ILE CA  HA   sing N N 179 
ILE C   O    doub N N 180 
ILE C   OXT  sing N N 181 
ILE CB  CG1  sing N N 182 
ILE CB  CG2  sing N N 183 
ILE CB  HB   sing N N 184 
ILE CG1 CD1  sing N N 185 
ILE CG1 HG12 sing N N 186 
ILE CG1 HG13 sing N N 187 
ILE CG2 HG21 sing N N 188 
ILE CG2 HG22 sing N N 189 
ILE CG2 HG23 sing N N 190 
ILE CD1 HD11 sing N N 191 
ILE CD1 HD12 sing N N 192 
ILE CD1 HD13 sing N N 193 
ILE OXT HXT  sing N N 194 
LEU N   CA   sing N N 195 
LEU N   H    sing N N 196 
LEU N   H2   sing N N 197 
LEU CA  C    sing N N 198 
LEU CA  CB   sing N N 199 
LEU CA  HA   sing N N 200 
LEU C   O    doub N N 201 
LEU C   OXT  sing N N 202 
LEU CB  CG   sing N N 203 
LEU CB  HB2  sing N N 204 
LEU CB  HB3  sing N N 205 
LEU CG  CD1  sing N N 206 
LEU CG  CD2  sing N N 207 
LEU CG  HG   sing N N 208 
LEU CD1 HD11 sing N N 209 
LEU CD1 HD12 sing N N 210 
LEU CD1 HD13 sing N N 211 
LEU CD2 HD21 sing N N 212 
LEU CD2 HD22 sing N N 213 
LEU CD2 HD23 sing N N 214 
LEU OXT HXT  sing N N 215 
LYS N   CA   sing N N 216 
LYS N   H    sing N N 217 
LYS N   H2   sing N N 218 
LYS CA  C    sing N N 219 
LYS CA  CB   sing N N 220 
LYS CA  HA   sing N N 221 
LYS C   O    doub N N 222 
LYS C   OXT  sing N N 223 
LYS CB  CG   sing N N 224 
LYS CB  HB2  sing N N 225 
LYS CB  HB3  sing N N 226 
LYS CG  CD   sing N N 227 
LYS CG  HG2  sing N N 228 
LYS CG  HG3  sing N N 229 
LYS CD  CE   sing N N 230 
LYS CD  HD2  sing N N 231 
LYS CD  HD3  sing N N 232 
LYS CE  NZ   sing N N 233 
LYS CE  HE2  sing N N 234 
LYS CE  HE3  sing N N 235 
LYS NZ  HZ1  sing N N 236 
LYS NZ  HZ2  sing N N 237 
LYS NZ  HZ3  sing N N 238 
LYS OXT HXT  sing N N 239 
MAN C1  C2   sing N N 240 
MAN C1  O1   sing N N 241 
MAN C1  O5   sing N N 242 
MAN C1  H1   sing N N 243 
MAN C2  C3   sing N N 244 
MAN C2  O2   sing N N 245 
MAN C2  H2   sing N N 246 
MAN C3  C4   sing N N 247 
MAN C3  O3   sing N N 248 
MAN C3  H3   sing N N 249 
MAN C4  C5   sing N N 250 
MAN C4  O4   sing N N 251 
MAN C4  H4   sing N N 252 
MAN C5  C6   sing N N 253 
MAN C5  O5   sing N N 254 
MAN C5  H5   sing N N 255 
MAN C6  O6   sing N N 256 
MAN C6  H61  sing N N 257 
MAN C6  H62  sing N N 258 
MAN O1  HO1  sing N N 259 
MAN O2  HO2  sing N N 260 
MAN O3  HO3  sing N N 261 
MAN O4  HO4  sing N N 262 
MAN O6  HO6  sing N N 263 
MET N   CA   sing N N 264 
MET N   H    sing N N 265 
MET N   H2   sing N N 266 
MET CA  C    sing N N 267 
MET CA  CB   sing N N 268 
MET CA  HA   sing N N 269 
MET C   O    doub N N 270 
MET C   OXT  sing N N 271 
MET CB  CG   sing N N 272 
MET CB  HB2  sing N N 273 
MET CB  HB3  sing N N 274 
MET CG  SD   sing N N 275 
MET CG  HG2  sing N N 276 
MET CG  HG3  sing N N 277 
MET SD  CE   sing N N 278 
MET CE  HE1  sing N N 279 
MET CE  HE2  sing N N 280 
MET CE  HE3  sing N N 281 
MET OXT HXT  sing N N 282 
NAG C1  C2   sing N N 283 
NAG C1  O1   sing N N 284 
NAG C1  O5   sing N N 285 
NAG C1  H1   sing N N 286 
NAG C2  C3   sing N N 287 
NAG C2  N2   sing N N 288 
NAG C2  H2   sing N N 289 
NAG C3  C4   sing N N 290 
NAG C3  O3   sing N N 291 
NAG C3  H3   sing N N 292 
NAG C4  C5   sing N N 293 
NAG C4  O4   sing N N 294 
NAG C4  H4   sing N N 295 
NAG C5  C6   sing N N 296 
NAG C5  O5   sing N N 297 
NAG C5  H5   sing N N 298 
NAG C6  O6   sing N N 299 
NAG C6  H61  sing N N 300 
NAG C6  H62  sing N N 301 
NAG C7  C8   sing N N 302 
NAG C7  N2   sing N N 303 
NAG C7  O7   doub N N 304 
NAG C8  H81  sing N N 305 
NAG C8  H82  sing N N 306 
NAG C8  H83  sing N N 307 
NAG N2  HN2  sing N N 308 
NAG O1  HO1  sing N N 309 
NAG O3  HO3  sing N N 310 
NAG O4  HO4  sing N N 311 
NAG O6  HO6  sing N N 312 
PHE N   CA   sing N N 313 
PHE N   H    sing N N 314 
PHE N   H2   sing N N 315 
PHE CA  C    sing N N 316 
PHE CA  CB   sing N N 317 
PHE CA  HA   sing N N 318 
PHE C   O    doub N N 319 
PHE C   OXT  sing N N 320 
PHE CB  CG   sing N N 321 
PHE CB  HB2  sing N N 322 
PHE CB  HB3  sing N N 323 
PHE CG  CD1  doub Y N 324 
PHE CG  CD2  sing Y N 325 
PHE CD1 CE1  sing Y N 326 
PHE CD1 HD1  sing N N 327 
PHE CD2 CE2  doub Y N 328 
PHE CD2 HD2  sing N N 329 
PHE CE1 CZ   doub Y N 330 
PHE CE1 HE1  sing N N 331 
PHE CE2 CZ   sing Y N 332 
PHE CE2 HE2  sing N N 333 
PHE CZ  HZ   sing N N 334 
PHE OXT HXT  sing N N 335 
PRO N   CA   sing N N 336 
PRO N   CD   sing N N 337 
PRO N   H    sing N N 338 
PRO CA  C    sing N N 339 
PRO CA  CB   sing N N 340 
PRO CA  HA   sing N N 341 
PRO C   O    doub N N 342 
PRO C   OXT  sing N N 343 
PRO CB  CG   sing N N 344 
PRO CB  HB2  sing N N 345 
PRO CB  HB3  sing N N 346 
PRO CG  CD   sing N N 347 
PRO CG  HG2  sing N N 348 
PRO CG  HG3  sing N N 349 
PRO CD  HD2  sing N N 350 
PRO CD  HD3  sing N N 351 
PRO OXT HXT  sing N N 352 
SER N   CA   sing N N 353 
SER N   H    sing N N 354 
SER N   H2   sing N N 355 
SER CA  C    sing N N 356 
SER CA  CB   sing N N 357 
SER CA  HA   sing N N 358 
SER C   O    doub N N 359 
SER C   OXT  sing N N 360 
SER CB  OG   sing N N 361 
SER CB  HB2  sing N N 362 
SER CB  HB3  sing N N 363 
SER OG  HG   sing N N 364 
SER OXT HXT  sing N N 365 
THR N   CA   sing N N 366 
THR N   H    sing N N 367 
THR N   H2   sing N N 368 
THR CA  C    sing N N 369 
THR CA  CB   sing N N 370 
THR CA  HA   sing N N 371 
THR C   O    doub N N 372 
THR C   OXT  sing N N 373 
THR CB  OG1  sing N N 374 
THR CB  CG2  sing N N 375 
THR CB  HB   sing N N 376 
THR OG1 HG1  sing N N 377 
THR CG2 HG21 sing N N 378 
THR CG2 HG22 sing N N 379 
THR CG2 HG23 sing N N 380 
THR OXT HXT  sing N N 381 
TRP N   CA   sing N N 382 
TRP N   H    sing N N 383 
TRP N   H2   sing N N 384 
TRP CA  C    sing N N 385 
TRP CA  CB   sing N N 386 
TRP CA  HA   sing N N 387 
TRP C   O    doub N N 388 
TRP C   OXT  sing N N 389 
TRP CB  CG   sing N N 390 
TRP CB  HB2  sing N N 391 
TRP CB  HB3  sing N N 392 
TRP CG  CD1  doub Y N 393 
TRP CG  CD2  sing Y N 394 
TRP CD1 NE1  sing Y N 395 
TRP CD1 HD1  sing N N 396 
TRP CD2 CE2  doub Y N 397 
TRP CD2 CE3  sing Y N 398 
TRP NE1 CE2  sing Y N 399 
TRP NE1 HE1  sing N N 400 
TRP CE2 CZ2  sing Y N 401 
TRP CE3 CZ3  doub Y N 402 
TRP CE3 HE3  sing N N 403 
TRP CZ2 CH2  doub Y N 404 
TRP CZ2 HZ2  sing N N 405 
TRP CZ3 CH2  sing Y N 406 
TRP CZ3 HZ3  sing N N 407 
TRP CH2 HH2  sing N N 408 
TRP OXT HXT  sing N N 409 
TYR N   CA   sing N N 410 
TYR N   H    sing N N 411 
TYR N   H2   sing N N 412 
TYR CA  C    sing N N 413 
TYR CA  CB   sing N N 414 
TYR CA  HA   sing N N 415 
TYR C   O    doub N N 416 
TYR C   OXT  sing N N 417 
TYR CB  CG   sing N N 418 
TYR CB  HB2  sing N N 419 
TYR CB  HB3  sing N N 420 
TYR CG  CD1  doub Y N 421 
TYR CG  CD2  sing Y N 422 
TYR CD1 CE1  sing Y N 423 
TYR CD1 HD1  sing N N 424 
TYR CD2 CE2  doub Y N 425 
TYR CD2 HD2  sing N N 426 
TYR CE1 CZ   doub Y N 427 
TYR CE1 HE1  sing N N 428 
TYR CE2 CZ   sing Y N 429 
TYR CE2 HE2  sing N N 430 
TYR CZ  OH   sing N N 431 
TYR OH  HH   sing N N 432 
TYR OXT HXT  sing N N 433 
VAL N   CA   sing N N 434 
VAL N   H    sing N N 435 
VAL N   H2   sing N N 436 
VAL CA  C    sing N N 437 
VAL CA  CB   sing N N 438 
VAL CA  HA   sing N N 439 
VAL C   O    doub N N 440 
VAL C   OXT  sing N N 441 
VAL CB  CG1  sing N N 442 
VAL CB  CG2  sing N N 443 
VAL CB  HB   sing N N 444 
VAL CG1 HG11 sing N N 445 
VAL CG1 HG12 sing N N 446 
VAL CG1 HG13 sing N N 447 
VAL CG2 HG21 sing N N 448 
VAL CG2 HG22 sing N N 449 
VAL CG2 HG23 sing N N 450 
VAL OXT HXT  sing N N 451 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2023-07-27 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           8K7S 
_em_admin.last_update        2025-01-29 
_em_admin.map_release_date   2024-12-04 
_em_admin.title              'Human Fc epsilon RI in complex with mIgE Fc (TMD disordered)' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     NONE 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                ? 
_em_entity_assembly_molwt.value                ? 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         61 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'             ? 2  ? ? 1 ? ? 
MASKING                         ? 3  ? ? ? ? ? 
'CTF CORRECTION'                ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'            ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'          ? 6  ? ? ? ? ? 
'MODEL FITTING'                 ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'              ? 8  ? ? ? ? ? 
OTHER                           ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ? ? 
CLASSIFICATION                  ? 12 1 ? ? ? ? 
RECONSTRUCTION                  ? 13 1 ? ? ? ? 
'VOLUME SELECTION'              ? 14 1 1 1 ? ? 
'SERIES ALIGNMENT'              ? 15 1 1 1 ? ? 
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ? ? 
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ? ? 
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ? ? 
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
loop_
_pdbx_entity_branch_list.entity_id 
_pdbx_entity_branch_list.comp_id 
_pdbx_entity_branch_list.num 
_pdbx_entity_branch_list.hetero 
3 NAG 1 n 
3 NAG 2 n 
3 BMA 3 n 
3 MAN 4 n 
3 MAN 5 n 
4 NAG 1 n 
4 NAG 2 n 
4 BMA 3 n 
# 
_atom_sites.entry_id                    8K7S 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ASP A 1 27  ? 159.416 102.803 133.759 1.00 71.69  ? 98  ASP F N   1 
ATOM   2    C CA  . ASP A 1 27  ? 158.823 104.132 133.848 1.00 71.69  ? 98  ASP F CA  1 
ATOM   3    C C   . ASP A 1 27  ? 157.349 104.053 134.231 1.00 71.69  ? 98  ASP F C   1 
ATOM   4    O O   . ASP A 1 27  ? 156.648 103.123 133.833 1.00 71.69  ? 98  ASP F O   1 
ATOM   5    C CB  . ASP A 1 27  ? 158.982 104.880 132.522 1.00 71.69  ? 98  ASP F CB  1 
ATOM   6    C CG  . ASP A 1 27  ? 160.434 105.138 132.169 1.00 71.69  ? 98  ASP F CG  1 
ATOM   7    O OD1 . ASP A 1 27  ? 161.256 105.281 133.098 1.00 71.69  ? 98  ASP F OD1 1 
ATOM   8    O OD2 . ASP A 1 27  ? 160.752 105.200 130.963 1.00 71.69  ? 98  ASP F OD2 1 
ATOM   9    N N   . PRO A 1 28  ? 156.878 105.032 135.005 1.00 68.63  ? 99  PRO F N   1 
ATOM   10   C CA  . PRO A 1 28  ? 155.461 105.047 135.393 1.00 68.63  ? 99  PRO F CA  1 
ATOM   11   C C   . PRO A 1 28  ? 154.557 105.409 134.226 1.00 68.63  ? 99  PRO F C   1 
ATOM   12   O O   . PRO A 1 28  ? 154.143 106.564 134.088 1.00 68.63  ? 99  PRO F O   1 
ATOM   13   C CB  . PRO A 1 28  ? 155.405 106.114 136.497 1.00 68.63  ? 99  PRO F CB  1 
ATOM   14   C CG  . PRO A 1 28  ? 156.830 106.319 136.926 1.00 68.63  ? 99  PRO F CG  1 
ATOM   15   C CD  . PRO A 1 28  ? 157.650 106.072 135.702 1.00 68.63  ? 99  PRO F CD  1 
ATOM   16   N N   . THR A 1 29  ? 154.250 104.430 133.378 1.00 65.81  ? 100 THR F N   1 
ATOM   17   C CA  . THR A 1 29  ? 153.411 104.660 132.204 1.00 65.81  ? 100 THR F CA  1 
ATOM   18   C C   . THR A 1 29  ? 151.992 104.959 132.667 1.00 65.81  ? 100 THR F C   1 
ATOM   19   O O   . THR A 1 29  ? 151.256 104.061 133.082 1.00 65.81  ? 100 THR F O   1 
ATOM   20   C CB  . THR A 1 29  ? 153.444 103.451 131.276 1.00 65.81  ? 100 THR F CB  1 
ATOM   21   O OG1 . THR A 1 29  ? 154.795 103.194 130.872 1.00 65.81  ? 100 THR F OG1 1 
ATOM   22   C CG2 . THR A 1 29  ? 152.592 103.706 130.040 1.00 65.81  ? 100 THR F CG2 1 
ATOM   23   N N   . LEU A 1 30  ? 151.603 106.230 132.600 1.00 62.43  ? 101 LEU F N   1 
ATOM   24   C CA  . LEU A 1 30  ? 150.298 106.666 133.084 1.00 62.43  ? 101 LEU F CA  1 
ATOM   25   C C   . LEU A 1 30  ? 149.271 106.520 131.969 1.00 62.43  ? 101 LEU F C   1 
ATOM   26   O O   . LEU A 1 30  ? 149.333 107.231 130.961 1.00 62.43  ? 101 LEU F O   1 
ATOM   27   C CB  . LEU A 1 30  ? 150.365 108.110 133.570 1.00 62.43  ? 101 LEU F CB  1 
ATOM   28   C CG  . LEU A 1 30  ? 151.468 108.471 134.565 1.00 62.43  ? 101 LEU F CG  1 
ATOM   29   C CD1 . LEU A 1 30  ? 151.338 109.926 134.983 1.00 62.43  ? 101 LEU F CD1 1 
ATOM   30   C CD2 . LEU A 1 30  ? 151.425 107.554 135.773 1.00 62.43  ? 101 LEU F CD2 1 
ATOM   31   N N   . GLU A 1 31  ? 148.325 105.602 132.146 1.00 57.61  ? 102 GLU F N   1 
ATOM   32   C CA  . GLU A 1 31  ? 147.178 105.486 131.249 1.00 57.61  ? 102 GLU F CA  1 
ATOM   33   C C   . GLU A 1 31  ? 146.008 106.198 131.915 1.00 57.61  ? 102 GLU F C   1 
ATOM   34   O O   . GLU A 1 31  ? 145.385 105.668 132.837 1.00 57.61  ? 102 GLU F O   1 
ATOM   35   C CB  . GLU A 1 31  ? 146.859 104.025 130.955 1.00 57.61  ? 102 GLU F CB  1 
ATOM   36   C CG  . GLU A 1 31  ? 147.948 103.296 130.184 1.00 57.61  ? 102 GLU F CG  1 
ATOM   37   C CD  . GLU A 1 31  ? 147.553 101.881 129.814 1.00 57.61  ? 102 GLU F CD  1 
ATOM   38   O OE1 . GLU A 1 31  ? 146.447 101.449 130.204 1.00 57.61  ? 102 GLU F OE1 1 
ATOM   39   O OE2 . GLU A 1 31  ? 148.347 101.199 129.132 1.00 57.61  ? 102 GLU F OE2 1 
ATOM   40   N N   . LEU A 1 32  ? 145.723 107.417 131.467 1.00 51.29  ? 103 LEU F N   1 
ATOM   41   C CA  . LEU A 1 32  ? 144.643 108.226 132.029 1.00 51.29  ? 103 LEU F CA  1 
ATOM   42   C C   . LEU A 1 32  ? 143.413 108.006 131.154 1.00 51.29  ? 103 LEU F C   1 
ATOM   43   O O   . LEU A 1 32  ? 143.179 108.725 130.182 1.00 51.29  ? 103 LEU F O   1 
ATOM   44   C CB  . LEU A 1 32  ? 145.046 109.693 132.107 1.00 51.29  ? 103 LEU F CB  1 
ATOM   45   C CG  . LEU A 1 32  ? 144.151 110.603 132.948 1.00 51.29  ? 103 LEU F CG  1 
ATOM   46   C CD1 . LEU A 1 32  ? 143.710 109.896 134.216 1.00 51.29  ? 103 LEU F CD1 1 
ATOM   47   C CD2 . LEU A 1 32  ? 144.886 111.890 133.286 1.00 51.29  ? 103 LEU F CD2 1 
ATOM   48   N N   . LEU A 1 33  ? 142.622 106.999 131.511 1.00 49.24  ? 104 LEU F N   1 
ATOM   49   C CA  . LEU A 1 33  ? 141.492 106.561 130.704 1.00 49.24  ? 104 LEU F CA  1 
ATOM   50   C C   . LEU A 1 33  ? 140.193 107.105 131.282 1.00 49.24  ? 104 LEU F C   1 
ATOM   51   O O   . LEU A 1 33  ? 139.958 107.020 132.492 1.00 49.24  ? 104 LEU F O   1 
ATOM   52   C CB  . LEU A 1 33  ? 141.438 105.034 130.635 1.00 49.24  ? 104 LEU F CB  1 
ATOM   53   C CG  . LEU A 1 33  ? 142.733 104.322 130.239 1.00 49.24  ? 104 LEU F CG  1 
ATOM   54   C CD1 . LEU A 1 33  ? 142.517 102.818 130.153 1.00 49.24  ? 104 LEU F CD1 1 
ATOM   55   C CD2 . LEU A 1 33  ? 143.273 104.866 128.926 1.00 49.24  ? 104 LEU F CD2 1 
ATOM   56   N N   . HIS A 1 34  ? 139.353 107.661 130.414 1.00 57.25  ? 105 HIS F N   1 
ATOM   57   C CA  . HIS A 1 34  ? 138.031 108.142 130.808 1.00 57.25  ? 105 HIS F CA  1 
ATOM   58   C C   . HIS A 1 34  ? 137.026 107.030 130.535 1.00 57.25  ? 105 HIS F C   1 
ATOM   59   O O   . HIS A 1 34  ? 136.876 106.575 129.398 1.00 57.25  ? 105 HIS F O   1 
ATOM   60   C CB  . HIS A 1 34  ? 137.678 109.425 130.065 1.00 57.25  ? 105 HIS F CB  1 
ATOM   61   C CG  . HIS A 1 34  ? 137.995 109.387 128.602 1.00 57.25  ? 105 HIS F CG  1 
ATOM   62   N ND1 . HIS A 1 34  ? 139.270 109.571 128.112 1.00 57.25  ? 105 HIS F ND1 1 
ATOM   63   C CD2 . HIS A 1 34  ? 137.201 109.201 127.522 1.00 57.25  ? 105 HIS F CD2 1 
ATOM   64   C CE1 . HIS A 1 34  ? 139.249 109.491 126.794 1.00 57.25  ? 105 HIS F CE1 1 
ATOM   65   N NE2 . HIS A 1 34  ? 138.005 109.267 126.410 1.00 57.25  ? 105 HIS F NE2 1 
ATOM   66   N N   . SER A 1 35  ? 136.338 106.588 131.585 1.00 63.00  ? 106 SER F N   1 
ATOM   67   C CA  . SER A 1 35  ? 135.372 105.511 131.454 1.00 63.00  ? 106 SER F CA  1 
ATOM   68   C C   . SER A 1 35  ? 134.165 105.971 130.636 1.00 63.00  ? 106 SER F C   1 
ATOM   69   O O   . SER A 1 35  ? 134.017 107.147 130.294 1.00 63.00  ? 106 SER F O   1 
ATOM   70   C CB  . SER A 1 35  ? 134.925 105.025 132.832 1.00 63.00  ? 106 SER F CB  1 
ATOM   71   O OG  . SER A 1 35  ? 134.330 106.075 133.576 1.00 63.00  ? 106 SER F OG  1 
ATOM   72   N N   . SER A 1 36  ? 133.299 105.012 130.315 1.00 73.53  ? 107 SER F N   1 
ATOM   73   C CA  . SER A 1 36  ? 132.093 105.311 129.563 1.00 73.53  ? 107 SER F CA  1 
ATOM   74   C C   . SER A 1 36  ? 131.218 106.297 130.337 1.00 73.53  ? 107 SER F C   1 
ATOM   75   O O   . SER A 1 36  ? 130.989 106.164 131.542 1.00 73.53  ? 107 SER F O   1 
ATOM   76   C CB  . SER A 1 36  ? 131.318 104.029 129.264 1.00 73.53  ? 107 SER F CB  1 
ATOM   77   O OG  . SER A 1 36  ? 130.125 104.309 128.553 1.00 73.53  ? 107 SER F OG  1 
ATOM   78   N N   . CYS A 1 37  ? 130.724 107.303 129.617 1.00 80.73  ? 108 CYS F N   1 
ATOM   79   C CA  . CYS A 1 37  ? 129.957 108.374 130.235 1.00 80.73  ? 108 CYS F CA  1 
ATOM   80   C C   . CYS A 1 37  ? 128.546 107.951 130.621 1.00 80.73  ? 108 CYS F C   1 
ATOM   81   O O   . CYS A 1 37  ? 127.879 108.683 131.362 1.00 80.73  ? 108 CYS F O   1 
ATOM   82   C CB  . CYS A 1 37  ? 129.915 109.589 129.299 1.00 80.73  ? 108 CYS F CB  1 
ATOM   83   S SG  . CYS A 1 37  ? 131.526 110.419 129.148 1.00 80.73  ? 108 CYS F SG  1 
ATOM   84   N N   . ASP A 1 38  ? 128.087 106.788 130.147 1.00 80.65  ? 109 ASP F N   1 
ATOM   85   C CA  . ASP A 1 38  ? 126.846 106.145 130.570 1.00 80.65  ? 109 ASP F CA  1 
ATOM   86   C C   . ASP A 1 38  ? 125.647 107.084 130.504 1.00 80.65  ? 109 ASP F C   1 
ATOM   87   O O   . ASP A 1 38  ? 125.117 107.483 131.548 1.00 80.65  ? 109 ASP F O   1 
ATOM   88   C CB  . ASP A 1 38  ? 126.996 105.595 131.990 1.00 80.65  ? 109 ASP F CB  1 
ATOM   89   C CG  . ASP A 1 38  ? 128.040 104.499 132.083 1.00 80.65  ? 109 ASP F CG  1 
ATOM   90   O OD1 . ASP A 1 38  ? 128.591 104.111 131.031 1.00 80.65  ? 109 ASP F OD1 1 
ATOM   91   O OD2 . ASP A 1 38  ? 128.310 104.026 133.207 1.00 80.65  ? 109 ASP F OD2 1 
ATOM   92   N N   . PRO A 1 39  ? 125.198 107.470 129.306 1.00 78.86  ? 110 PRO F N   1 
ATOM   93   C CA  . PRO A 1 39  ? 123.990 108.309 129.221 1.00 78.86  ? 110 PRO F CA  1 
ATOM   94   C C   . PRO A 1 39  ? 122.747 107.637 129.783 1.00 78.86  ? 110 PRO F C   1 
ATOM   95   O O   . PRO A 1 39  ? 121.881 108.311 130.355 1.00 78.86  ? 110 PRO F O   1 
ATOM   96   C CB  . PRO A 1 39  ? 123.873 108.584 127.716 1.00 78.86  ? 110 PRO F CB  1 
ATOM   97   C CG  . PRO A 1 39  ? 124.547 107.420 127.072 1.00 78.86  ? 110 PRO F CG  1 
ATOM   98   C CD  . PRO A 1 39  ? 125.694 107.075 127.976 1.00 78.86  ? 110 PRO F CD  1 
ATOM   99   N N   . ASN A 1 40  ? 122.635 106.314 129.633 1.00 81.95  ? 111 ASN F N   1 
ATOM   100  C CA  . ASN A 1 40  ? 121.435 105.612 130.076 1.00 81.95  ? 111 ASN F CA  1 
ATOM   101  C C   . ASN A 1 40  ? 121.333 105.574 131.596 1.00 81.95  ? 111 ASN F C   1 
ATOM   102  O O   . ASN A 1 40  ? 120.247 105.754 132.158 1.00 81.95  ? 111 ASN F O   1 
ATOM   103  C CB  . ASN A 1 40  ? 121.419 104.194 129.503 1.00 81.95  ? 111 ASN F CB  1 
ATOM   104  C CG  . ASN A 1 40  ? 120.130 103.455 129.806 1.00 81.95  ? 111 ASN F CG  1 
ATOM   105  O OD1 . ASN A 1 40  ? 119.094 104.069 130.062 1.00 81.95  ? 111 ASN F OD1 1 
ATOM   106  N ND2 . ASN A 1 40  ? 120.187 102.128 129.777 1.00 81.95  ? 111 ASN F ND2 1 
ATOM   107  N N   . ALA A 1 41  ? 122.451 105.340 132.277 1.00 77.67  ? 112 ALA F N   1 
ATOM   108  C CA  . ALA A 1 41  ? 122.441 105.214 133.725 1.00 77.67  ? 112 ALA F CA  1 
ATOM   109  C C   . ALA A 1 41  ? 122.567 106.584 134.390 1.00 77.67  ? 112 ALA F C   1 
ATOM   110  O O   . ALA A 1 41  ? 122.928 107.584 133.764 1.00 77.67  ? 112 ALA F O   1 
ATOM   111  C CB  . ALA A 1 41  ? 123.566 104.290 134.189 1.00 77.67  ? 112 ALA F CB  1 
ATOM   112  N N   . PHE A 1 42  ? 122.261 106.618 135.686 1.00 65.05  ? 113 PHE F N   1 
ATOM   113  C CA  . PHE A 1 42  ? 122.365 107.835 136.492 1.00 65.05  ? 113 PHE F CA  1 
ATOM   114  C C   . PHE A 1 42  ? 123.753 108.012 137.091 1.00 65.05  ? 113 PHE F C   1 
ATOM   115  O O   . PHE A 1 42  ? 123.908 108.154 138.307 1.00 65.05  ? 113 PHE F O   1 
ATOM   116  C CB  . PHE A 1 42  ? 121.293 107.832 137.580 1.00 65.05  ? 113 PHE F CB  1 
ATOM   117  C CG  . PHE A 1 42  ? 121.147 106.515 138.298 1.00 65.05  ? 113 PHE F CG  1 
ATOM   118  C CD1 . PHE A 1 42  ? 120.281 105.543 137.822 1.00 65.05  ? 113 PHE F CD1 1 
ATOM   119  C CD2 . PHE A 1 42  ? 121.858 106.258 139.459 1.00 65.05  ? 113 PHE F CD2 1 
ATOM   120  C CE1 . PHE A 1 42  ? 120.140 104.336 138.482 1.00 65.05  ? 113 PHE F CE1 1 
ATOM   121  C CE2 . PHE A 1 42  ? 121.721 105.054 140.123 1.00 65.05  ? 113 PHE F CE2 1 
ATOM   122  C CZ  . PHE A 1 42  ? 120.860 104.092 139.634 1.00 65.05  ? 113 PHE F CZ  1 
ATOM   123  N N   . HIS A 1 43  ? 124.783 108.024 136.245 1.00 68.07  ? 114 HIS F N   1 
ATOM   124  C CA  . HIS A 1 43  ? 126.172 108.134 136.671 1.00 68.07  ? 114 HIS F CA  1 
ATOM   125  C C   . HIS A 1 43  ? 126.855 109.369 136.094 1.00 68.07  ? 114 HIS F C   1 
ATOM   126  O O   . HIS A 1 43  ? 127.938 109.259 135.508 1.00 68.07  ? 114 HIS F O   1 
ATOM   127  C CB  . HIS A 1 43  ? 126.943 106.868 136.296 1.00 68.07  ? 114 HIS F CB  1 
ATOM   128  C CG  . HIS A 1 43  ? 126.574 105.673 137.118 1.00 68.07  ? 114 HIS F CG  1 
ATOM   129  N ND1 . HIS A 1 43  ? 126.688 104.382 136.649 1.00 68.07  ? 114 HIS F ND1 1 
ATOM   130  C CD2 . HIS A 1 43  ? 126.096 105.573 138.381 1.00 68.07  ? 114 HIS F CD2 1 
ATOM   131  C CE1 . HIS A 1 43  ? 126.294 103.539 137.586 1.00 68.07  ? 114 HIS F CE1 1 
ATOM   132  N NE2 . HIS A 1 43  ? 125.930 104.236 138.648 1.00 68.07  ? 114 HIS F NE2 1 
ATOM   133  N N   . SER A 1 44  ? 126.217 110.536 136.225 1.00 61.77  ? 115 SER F N   1 
ATOM   134  C CA  . SER A 1 44  ? 126.693 111.810 135.691 1.00 61.77  ? 115 SER F CA  1 
ATOM   135  C C   . SER A 1 44  ? 128.197 112.001 135.840 1.00 61.77  ? 115 SER F C   1 
ATOM   136  O O   . SER A 1 44  ? 128.869 112.424 134.893 1.00 61.77  ? 115 SER F O   1 
ATOM   137  C CB  . SER A 1 44  ? 125.965 112.968 136.377 1.00 61.77  ? 115 SER F CB  1 
ATOM   138  O OG  . SER A 1 44  ? 126.422 114.218 135.891 1.00 61.77  ? 115 SER F OG  1 
ATOM   139  N N   . THR A 1 45  ? 128.734 111.698 137.018 1.00 64.22  ? 116 THR F N   1 
ATOM   140  C CA  . THR A 1 45  ? 130.156 111.864 137.276 1.00 64.22  ? 116 THR F CA  1 
ATOM   141  C C   . THR A 1 45  ? 130.953 110.816 136.508 1.00 64.22  ? 116 THR F C   1 
ATOM   142  O O   . THR A 1 45  ? 130.636 109.623 136.553 1.00 64.22  ? 116 THR F O   1 
ATOM   143  C CB  . THR A 1 45  ? 130.454 111.769 138.774 1.00 64.22  ? 116 THR F CB  1 
ATOM   144  O OG1 . THR A 1 45  ? 131.865 111.622 138.975 1.00 64.22  ? 116 THR F OG1 1 
ATOM   145  C CG2 . THR A 1 45  ? 129.722 110.590 139.402 1.00 64.22  ? 116 THR F CG2 1 
ATOM   146  N N   . ILE A 1 46  ? 131.977 111.272 135.797 1.00 58.79  ? 117 ILE F N   1 
ATOM   147  C CA  . ILE A 1 46  ? 132.878 110.386 135.072 1.00 58.79  ? 117 ILE F CA  1 
ATOM   148  C C   . ILE A 1 46  ? 134.033 110.006 135.987 1.00 58.79  ? 117 ILE F C   1 
ATOM   149  O O   . ILE A 1 46  ? 134.563 110.844 136.730 1.00 58.79  ? 117 ILE F O   1 
ATOM   150  C CB  . ILE A 1 46  ? 133.377 111.056 133.778 1.00 58.79  ? 117 ILE F CB  1 
ATOM   151  C CG1 . ILE A 1 46  ? 132.216 111.298 132.807 1.00 58.79  ? 117 ILE F CG1 1 
ATOM   152  C CG2 . ILE A 1 46  ? 134.453 110.212 133.108 1.00 58.79  ? 117 ILE F CG2 1 
ATOM   153  C CD1 . ILE A 1 46  ? 131.573 112.666 132.931 1.00 58.79  ? 117 ILE F CD1 1 
ATOM   154  N N   . GLN A 1 47  ? 134.416 108.731 135.948 1.00 56.82  ? 118 GLN F N   1 
ATOM   155  C CA  . GLN A 1 47  ? 135.474 108.194 136.802 1.00 56.82  ? 118 GLN F CA  1 
ATOM   156  C C   . GLN A 1 47  ? 136.738 108.049 135.960 1.00 56.82  ? 118 GLN F C   1 
ATOM   157  O O   . GLN A 1 47  ? 136.958 107.030 135.305 1.00 56.82  ? 118 GLN F O   1 
ATOM   158  C CB  . GLN A 1 47  ? 135.053 106.863 137.418 1.00 56.82  ? 118 GLN F CB  1 
ATOM   159  C CG  . GLN A 1 47  ? 133.744 106.905 138.195 1.00 56.82  ? 118 GLN F CG  1 
ATOM   160  C CD  . GLN A 1 47  ? 132.525 106.760 137.303 1.00 56.82  ? 118 GLN F CD  1 
ATOM   161  O OE1 . GLN A 1 47  ? 132.646 106.570 136.093 1.00 56.82  ? 118 GLN F OE1 1 
ATOM   162  N NE2 . GLN A 1 47  ? 131.341 106.848 137.899 1.00 56.82  ? 118 GLN F NE2 1 
ATOM   163  N N   . LEU A 1 48  ? 137.573 109.085 135.980 1.00 52.68  ? 119 LEU F N   1 
ATOM   164  C CA  . LEU A 1 48  ? 138.878 109.015 135.334 1.00 52.68  ? 119 LEU F CA  1 
ATOM   165  C C   . LEU A 1 48  ? 139.765 108.031 136.084 1.00 52.68  ? 119 LEU F C   1 
ATOM   166  O O   . LEU A 1 48  ? 140.005 108.199 137.284 1.00 52.68  ? 119 LEU F O   1 
ATOM   167  C CB  . LEU A 1 48  ? 139.530 110.395 135.299 1.00 52.68  ? 119 LEU F CB  1 
ATOM   168  C CG  . LEU A 1 48  ? 139.191 111.339 134.147 1.00 52.68  ? 119 LEU F CG  1 
ATOM   169  C CD1 . LEU A 1 48  ? 139.843 112.693 134.371 1.00 52.68  ? 119 LEU F CD1 1 
ATOM   170  C CD2 . LEU A 1 48  ? 139.644 110.746 132.827 1.00 52.68  ? 119 LEU F CD2 1 
ATOM   171  N N   . TYR A 1 49  ? 140.246 107.006 135.383 1.00 50.02  ? 120 TYR F N   1 
ATOM   172  C CA  . TYR A 1 49  ? 141.144 106.013 135.956 1.00 50.02  ? 120 TYR F CA  1 
ATOM   173  C C   . TYR A 1 49  ? 142.566 106.327 135.509 1.00 50.02  ? 120 TYR F C   1 
ATOM   174  O O   . TYR A 1 49  ? 142.866 106.289 134.311 1.00 50.02  ? 120 TYR F O   1 
ATOM   175  C CB  . TYR A 1 49  ? 140.752 104.600 135.523 1.00 50.02  ? 120 TYR F CB  1 
ATOM   176  C CG  . TYR A 1 49  ? 139.370 104.165 135.956 1.00 50.02  ? 120 TYR F CG  1 
ATOM   177  C CD1 . TYR A 1 49  ? 138.782 104.681 137.103 1.00 50.02  ? 120 TYR F CD1 1 
ATOM   178  C CD2 . TYR A 1 49  ? 138.654 103.231 135.217 1.00 50.02  ? 120 TYR F CD2 1 
ATOM   179  C CE1 . TYR A 1 49  ? 137.519 104.281 137.499 1.00 50.02  ? 120 TYR F CE1 1 
ATOM   180  C CE2 . TYR A 1 49  ? 137.392 102.826 135.606 1.00 50.02  ? 120 TYR F CE2 1 
ATOM   181  C CZ  . TYR A 1 49  ? 136.829 103.354 136.748 1.00 50.02  ? 120 TYR F CZ  1 
ATOM   182  O OH  . TYR A 1 49  ? 135.573 102.954 137.140 1.00 50.02  ? 120 TYR F OH  1 
ATOM   183  N N   . CYS A 1 50  ? 143.437 106.635 136.469 1.00 53.92  ? 121 CYS F N   1 
ATOM   184  C CA  . CYS A 1 50  ? 144.848 106.884 136.182 1.00 53.92  ? 121 CYS F CA  1 
ATOM   185  C C   . CYS A 1 50  ? 145.625 105.610 136.499 1.00 53.92  ? 121 CYS F C   1 
ATOM   186  O O   . CYS A 1 50  ? 146.202 105.447 137.574 1.00 53.92  ? 121 CYS F O   1 
ATOM   187  C CB  . CYS A 1 50  ? 145.362 108.083 136.976 1.00 53.92  ? 121 CYS F CB  1 
ATOM   188  S SG  . CYS A 1 50  ? 147.096 108.503 136.662 1.00 53.92  ? 121 CYS F SG  1 
ATOM   189  N N   . PHE A 1 51  ? 145.621 104.685 135.540 1.00 53.04  ? 122 PHE F N   1 
ATOM   190  C CA  . PHE A 1 51  ? 146.375 103.444 135.675 1.00 53.04  ? 122 PHE F CA  1 
ATOM   191  C C   . PHE A 1 51  ? 147.864 103.764 135.703 1.00 53.04  ? 122 PHE F C   1 
ATOM   192  O O   . PHE A 1 51  ? 148.426 104.241 134.711 1.00 53.04  ? 122 PHE F O   1 
ATOM   193  C CB  . PHE A 1 51  ? 146.040 102.492 134.531 1.00 53.04  ? 122 PHE F CB  1 
ATOM   194  C CG  . PHE A 1 51  ? 144.646 101.937 134.590 1.00 53.04  ? 122 PHE F CG  1 
ATOM   195  C CD1 . PHE A 1 51  ? 144.342 100.883 135.437 1.00 53.04  ? 122 PHE F CD1 1 
ATOM   196  C CD2 . PHE A 1 51  ? 143.642 102.461 133.794 1.00 53.04  ? 122 PHE F CD2 1 
ATOM   197  C CE1 . PHE A 1 51  ? 143.062 100.367 135.493 1.00 53.04  ? 122 PHE F CE1 1 
ATOM   198  C CE2 . PHE A 1 51  ? 142.360 101.948 133.845 1.00 53.04  ? 122 PHE F CE2 1 
ATOM   199  C CZ  . PHE A 1 51  ? 142.069 100.901 134.696 1.00 53.04  ? 122 PHE F CZ  1 
ATOM   200  N N   . ILE A 1 52  ? 148.500 103.509 136.841 1.00 59.65  ? 123 ILE F N   1 
ATOM   201  C CA  . ILE A 1 52  ? 149.913 103.792 137.054 1.00 59.65  ? 123 ILE F CA  1 
ATOM   202  C C   . ILE A 1 52  ? 150.645 102.464 137.165 1.00 59.65  ? 123 ILE F C   1 
ATOM   203  O O   . ILE A 1 52  ? 150.298 101.621 138.006 1.00 59.65  ? 123 ILE F O   1 
ATOM   204  C CB  . ILE A 1 52  ? 150.137 104.652 138.308 1.00 59.65  ? 123 ILE F CB  1 
ATOM   205  C CG1 . ILE A 1 52  ? 149.304 105.933 138.233 1.00 59.65  ? 123 ILE F CG1 1 
ATOM   206  C CG2 . ILE A 1 52  ? 151.612 104.984 138.467 1.00 59.65  ? 123 ILE F CG2 1 
ATOM   207  C CD1 . ILE A 1 52  ? 149.470 106.839 139.432 1.00 59.65  ? 123 ILE F CD1 1 
ATOM   208  N N   . TYR A 1 53  ? 151.649 102.281 136.308 1.00 64.14  ? 124 TYR F N   1 
ATOM   209  C CA  . TYR A 1 53  ? 152.521 101.118 136.317 1.00 64.14  ? 124 TYR F CA  1 
ATOM   210  C C   . TYR A 1 53  ? 153.967 101.581 136.217 1.00 64.14  ? 124 TYR F C   1 
ATOM   211  O O   . TYR A 1 53  ? 154.254 102.660 135.689 1.00 64.14  ? 124 TYR F O   1 
ATOM   212  C CB  . TYR A 1 53  ? 152.218 100.158 135.155 1.00 64.14  ? 124 TYR F CB  1 
ATOM   213  C CG  . TYR A 1 53  ? 150.750 99.885  134.921 1.00 64.14  ? 124 TYR F CG  1 
ATOM   214  C CD1 . TYR A 1 53  ? 150.083 98.898  135.633 1.00 64.14  ? 124 TYR F CD1 1 
ATOM   215  C CD2 . TYR A 1 53  ? 150.035 100.604 133.972 1.00 64.14  ? 124 TYR F CD2 1 
ATOM   216  C CE1 . TYR A 1 53  ? 148.742 98.643  135.415 1.00 64.14  ? 124 TYR F CE1 1 
ATOM   217  C CE2 . TYR A 1 53  ? 148.696 100.355 133.746 1.00 64.14  ? 124 TYR F CE2 1 
ATOM   218  C CZ  . TYR A 1 53  ? 148.054 99.374  134.471 1.00 64.14  ? 124 TYR F CZ  1 
ATOM   219  O OH  . TYR A 1 53  ? 146.719 99.123  134.251 1.00 64.14  ? 124 TYR F OH  1 
ATOM   220  N N   . GLY A 1 54  ? 154.876 100.752 136.723 1.00 76.52  ? 125 GLY F N   1 
ATOM   221  C CA  . GLY A 1 54  ? 156.292 101.040 136.661 1.00 76.52  ? 125 GLY F CA  1 
ATOM   222  C C   . GLY A 1 54  ? 156.841 101.851 137.813 1.00 76.52  ? 125 GLY F C   1 
ATOM   223  O O   . GLY A 1 54  ? 158.053 102.103 137.847 1.00 76.52  ? 125 GLY F O   1 
ATOM   224  N N   . HIS A 1 55  ? 155.999 102.270 138.753 1.00 85.16  ? 126 HIS F N   1 
ATOM   225  C CA  . HIS A 1 55  ? 156.452 103.054 139.893 1.00 85.16  ? 126 HIS F CA  1 
ATOM   226  C C   . HIS A 1 55  ? 157.046 102.120 140.948 1.00 85.16  ? 126 HIS F C   1 
ATOM   227  O O   . HIS A 1 55  ? 157.224 100.920 140.726 1.00 85.16  ? 126 HIS F O   1 
ATOM   228  C CB  . HIS A 1 55  ? 155.305 103.894 140.446 1.00 85.16  ? 126 HIS F CB  1 
ATOM   229  C CG  . HIS A 1 55  ? 154.219 103.088 141.087 1.00 85.16  ? 126 HIS F CG  1 
ATOM   230  N ND1 . HIS A 1 55  ? 154.285 102.657 142.394 1.00 85.16  ? 126 HIS F ND1 1 
ATOM   231  C CD2 . HIS A 1 55  ? 153.039 102.634 140.601 1.00 85.16  ? 126 HIS F CD2 1 
ATOM   232  C CE1 . HIS A 1 55  ? 153.193 101.973 142.686 1.00 85.16  ? 126 HIS F CE1 1 
ATOM   233  N NE2 . HIS A 1 55  ? 152.421 101.944 141.615 1.00 85.16  ? 126 HIS F NE2 1 
ATOM   234  N N   . ILE A 1 56  ? 157.358 102.670 142.118 1.00 98.07  ? 127 ILE F N   1 
ATOM   235  C CA  . ILE A 1 56  ? 157.951 101.913 143.212 1.00 98.07  ? 127 ILE F CA  1 
ATOM   236  C C   . ILE A 1 56  ? 156.967 101.882 144.372 1.00 98.07  ? 127 ILE F C   1 
ATOM   237  O O   . ILE A 1 56  ? 156.234 102.847 144.616 1.00 98.07  ? 127 ILE F O   1 
ATOM   238  C CB  . ILE A 1 56  ? 159.306 102.511 143.650 1.00 98.07  ? 127 ILE F CB  1 
ATOM   239  C CG1 . ILE A 1 56  ? 160.191 102.765 142.428 1.00 98.07  ? 127 ILE F CG1 1 
ATOM   240  C CG2 . ILE A 1 56  ? 160.017 101.585 144.626 1.00 98.07  ? 127 ILE F CG2 1 
ATOM   241  C CD1 . ILE A 1 56  ? 161.550 103.329 142.767 1.00 98.07  ? 127 ILE F CD1 1 
ATOM   242  N N   . LEU A 1 57  ? 156.948 100.756 145.084 1.00 103.60 ? 128 LEU F N   1 
ATOM   243  C CA  . LEU A 1 57  ? 156.044 100.598 146.215 1.00 103.60 ? 128 LEU F CA  1 
ATOM   244  C C   . LEU A 1 57  ? 156.357 101.621 147.300 1.00 103.60 ? 128 LEU F C   1 
ATOM   245  O O   . LEU A 1 57  ? 157.518 101.970 147.531 1.00 103.60 ? 128 LEU F O   1 
ATOM   246  C CB  . LEU A 1 57  ? 156.138 99.178  146.782 1.00 103.60 ? 128 LEU F CB  1 
ATOM   247  C CG  . LEU A 1 57  ? 157.425 98.729  147.482 1.00 103.60 ? 128 LEU F CG  1 
ATOM   248  C CD1 . LEU A 1 57  ? 157.138 97.557  148.407 1.00 103.60 ? 128 LEU F CD1 1 
ATOM   249  C CD2 . LEU A 1 57  ? 158.510 98.353  146.482 1.00 103.60 ? 128 LEU F CD2 1 
ATOM   250  N N   . ASN A 1 58  ? 155.297 102.114 147.949 1.00 106.69 ? 129 ASN F N   1 
ATOM   251  C CA  . ASN A 1 58  ? 155.346 103.120 149.011 1.00 106.69 ? 129 ASN F CA  1 
ATOM   252  C C   . ASN A 1 58  ? 156.292 104.272 148.684 1.00 106.69 ? 129 ASN F C   1 
ATOM   253  O O   . ASN A 1 58  ? 156.920 104.842 149.582 1.00 106.69 ? 129 ASN F O   1 
ATOM   254  C CB  . ASN A 1 58  ? 155.721 102.477 150.356 1.00 106.69 ? 129 ASN F CB  1 
ATOM   255  C CG  . ASN A 1 58  ? 157.147 101.958 150.395 1.00 106.69 ? 129 ASN F CG  1 
ATOM   256  O OD1 . ASN A 1 58  ? 157.403 100.789 150.103 1.00 106.69 ? 129 ASN F OD1 1 
ATOM   257  N ND2 . ASN A 1 58  ? 158.084 102.824 150.765 1.00 106.69 ? 129 ASN F ND2 1 
ATOM   258  N N   . ASP A 1 59  ? 156.393 104.627 147.400 1.00 105.15 ? 130 ASP F N   1 
ATOM   259  C CA  . ASP A 1 59  ? 157.232 105.738 146.969 1.00 105.15 ? 130 ASP F CA  1 
ATOM   260  C C   . ASP A 1 59  ? 156.550 106.546 145.869 1.00 105.15 ? 130 ASP F C   1 
ATOM   261  O O   . ASP A 1 59  ? 157.221 107.211 145.073 1.00 105.15 ? 130 ASP F O   1 
ATOM   262  C CB  . ASP A 1 59  ? 158.599 105.238 146.493 1.00 105.15 ? 130 ASP F CB  1 
ATOM   263  C CG  . ASP A 1 59  ? 159.652 106.331 146.484 1.00 105.15 ? 130 ASP F CG  1 
ATOM   264  O OD1 . ASP A 1 59  ? 160.041 106.793 147.577 1.00 105.15 ? 130 ASP F OD1 1 
ATOM   265  O OD2 . ASP A 1 59  ? 160.092 106.726 145.383 1.00 105.15 ? 130 ASP F OD2 1 
ATOM   266  N N   . VAL A 1 60  ? 155.221 106.501 145.811 1.00 97.06  ? 131 VAL F N   1 
ATOM   267  C CA  . VAL A 1 60  ? 154.452 107.150 144.757 1.00 97.06  ? 131 VAL F CA  1 
ATOM   268  C C   . VAL A 1 60  ? 153.386 108.027 145.399 1.00 97.06  ? 131 VAL F C   1 
ATOM   269  O O   . VAL A 1 60  ? 152.647 107.571 146.278 1.00 97.06  ? 131 VAL F O   1 
ATOM   270  C CB  . VAL A 1 60  ? 153.811 106.119 143.807 1.00 97.06  ? 131 VAL F CB  1 
ATOM   271  C CG1 . VAL A 1 60  ? 153.221 104.959 144.597 1.00 97.06  ? 131 VAL F CG1 1 
ATOM   272  C CG2 . VAL A 1 60  ? 152.743 106.774 142.946 1.00 97.06  ? 131 VAL F CG2 1 
ATOM   273  N N   . SER A 1 61  ? 153.314 109.284 144.968 1.00 91.04  ? 132 SER F N   1 
ATOM   274  C CA  . SER A 1 61  ? 152.255 110.195 145.386 1.00 91.04  ? 132 SER F CA  1 
ATOM   275  C C   . SER A 1 61  ? 151.467 110.627 144.159 1.00 91.04  ? 132 SER F C   1 
ATOM   276  O O   . SER A 1 61  ? 152.057 110.998 143.138 1.00 91.04  ? 132 SER F O   1 
ATOM   277  C CB  . SER A 1 61  ? 152.820 111.416 146.118 1.00 91.04  ? 132 SER F CB  1 
ATOM   278  O OG  . SER A 1 61  ? 153.229 112.416 145.204 1.00 91.04  ? 132 SER F OG  1 
ATOM   279  N N   . VAL A 1 62  ? 150.140 110.582 144.261 1.00 79.05  ? 133 VAL F N   1 
ATOM   280  C CA  . VAL A 1 62  ? 149.243 110.842 143.140 1.00 79.05  ? 133 VAL F CA  1 
ATOM   281  C C   . VAL A 1 62  ? 148.487 112.136 143.408 1.00 79.05  ? 133 VAL F C   1 
ATOM   282  O O   . VAL A 1 62  ? 147.949 112.334 144.504 1.00 79.05  ? 133 VAL F O   1 
ATOM   283  C CB  . VAL A 1 62  ? 148.267 109.673 142.920 1.00 79.05  ? 133 VAL F CB  1 
ATOM   284  C CG1 . VAL A 1 62  ? 147.411 109.918 141.687 1.00 79.05  ? 133 VAL F CG1 1 
ATOM   285  C CG2 . VAL A 1 62  ? 149.029 108.362 142.799 1.00 79.05  ? 133 VAL F CG2 1 
ATOM   286  N N   . SER A 1 63  ? 148.448 113.014 142.406 1.00 73.75  ? 134 SER F N   1 
ATOM   287  C CA  . SER A 1 63  ? 147.746 114.284 142.506 1.00 73.75  ? 134 SER F CA  1 
ATOM   288  C C   . SER A 1 63  ? 146.946 114.524 141.234 1.00 73.75  ? 134 SER F C   1 
ATOM   289  O O   . SER A 1 63  ? 147.272 113.998 140.166 1.00 73.75  ? 134 SER F O   1 
ATOM   290  C CB  . SER A 1 63  ? 148.716 115.449 142.744 1.00 73.75  ? 134 SER F CB  1 
ATOM   291  O OG  . SER A 1 63  ? 149.445 115.269 143.946 1.00 73.75  ? 134 SER F OG  1 
ATOM   292  N N   . TRP A 1 64  ? 145.895 115.330 141.361 1.00 65.90  ? 135 TRP F N   1 
ATOM   293  C CA  . TRP A 1 64  ? 145.022 115.677 140.248 1.00 65.90  ? 135 TRP F CA  1 
ATOM   294  C C   . TRP A 1 64  ? 145.055 117.181 140.016 1.00 65.90  ? 135 TRP F C   1 
ATOM   295  O O   . TRP A 1 64  ? 145.012 117.967 140.967 1.00 65.90  ? 135 TRP F O   1 
ATOM   296  C CB  . TRP A 1 64  ? 143.583 115.225 140.508 1.00 65.90  ? 135 TRP F CB  1 
ATOM   297  C CG  . TRP A 1 64  ? 143.406 113.740 140.510 1.00 65.90  ? 135 TRP F CG  1 
ATOM   298  C CD1 . TRP A 1 64  ? 143.247 112.934 141.599 1.00 65.90  ? 135 TRP F CD1 1 
ATOM   299  C CD2 . TRP A 1 64  ? 143.368 112.882 139.365 1.00 65.90  ? 135 TRP F CD2 1 
ATOM   300  N NE1 . TRP A 1 64  ? 143.111 111.625 141.202 1.00 65.90  ? 135 TRP F NE1 1 
ATOM   301  C CE2 . TRP A 1 64  ? 143.183 111.567 139.835 1.00 65.90  ? 135 TRP F CE2 1 
ATOM   302  C CE3 . TRP A 1 64  ? 143.475 113.097 137.987 1.00 65.90  ? 135 TRP F CE3 1 
ATOM   303  C CZ2 . TRP A 1 64  ? 143.100 110.473 138.977 1.00 65.90  ? 135 TRP F CZ2 1 
ATOM   304  C CZ3 . TRP A 1 64  ? 143.390 112.010 137.138 1.00 65.90  ? 135 TRP F CZ3 1 
ATOM   305  C CH2 . TRP A 1 64  ? 143.205 110.716 137.636 1.00 65.90  ? 135 TRP F CH2 1 
ATOM   306  N N   . LEU A 1 65  ? 145.129 117.575 138.746 1.00 69.99  ? 136 LEU F N   1 
ATOM   307  C CA  . LEU A 1 65  ? 145.148 118.978 138.359 1.00 69.99  ? 136 LEU F CA  1 
ATOM   308  C C   . LEU A 1 65  ? 144.071 119.235 137.316 1.00 69.99  ? 136 LEU F C   1 
ATOM   309  O O   . LEU A 1 65  ? 143.870 118.426 136.406 1.00 69.99  ? 136 LEU F O   1 
ATOM   310  C CB  . LEU A 1 65  ? 146.520 119.395 137.801 1.00 69.99  ? 136 LEU F CB  1 
ATOM   311  C CG  . LEU A 1 65  ? 147.703 119.504 138.769 1.00 69.99  ? 136 LEU F CG  1 
ATOM   312  C CD1 . LEU A 1 65  ? 148.293 118.139 139.099 1.00 69.99  ? 136 LEU F CD1 1 
ATOM   313  C CD2 . LEU A 1 65  ? 148.771 120.428 138.202 1.00 69.99  ? 136 LEU F CD2 1 
ATOM   314  N N   . MET A 1 66  ? 143.382 120.366 137.452 1.00 73.19  ? 137 MET F N   1 
ATOM   315  C CA  . MET A 1 66  ? 142.346 120.790 136.512 1.00 73.19  ? 137 MET F CA  1 
ATOM   316  C C   . MET A 1 66  ? 142.826 122.074 135.840 1.00 73.19  ? 137 MET F C   1 
ATOM   317  O O   . MET A 1 66  ? 142.636 123.171 136.372 1.00 73.19  ? 137 MET F O   1 
ATOM   318  C CB  . MET A 1 66  ? 141.003 120.992 137.216 1.00 73.19  ? 137 MET F CB  1 
ATOM   319  C CG  . MET A 1 66  ? 139.874 121.399 136.281 1.00 73.19  ? 137 MET F CG  1 
ATOM   320  S SD  . MET A 1 66  ? 138.291 121.602 137.120 1.00 73.19  ? 137 MET F SD  1 
ATOM   321  C CE  . MET A 1 66  ? 138.634 123.023 138.154 1.00 73.19  ? 137 MET F CE  1 
ATOM   322  N N   . ASP A 1 67  ? 143.444 121.927 134.666 1.00 73.13  ? 138 ASP F N   1 
ATOM   323  C CA  . ASP A 1 67  ? 143.982 123.048 133.895 1.00 73.13  ? 138 ASP F CA  1 
ATOM   324  C C   . ASP A 1 67  ? 144.959 123.870 134.740 1.00 73.13  ? 138 ASP F C   1 
ATOM   325  O O   . ASP A 1 67  ? 144.744 125.051 135.022 1.00 73.13  ? 138 ASP F O   1 
ATOM   326  C CB  . ASP A 1 67  ? 142.852 123.922 133.337 1.00 73.13  ? 138 ASP F CB  1 
ATOM   327  C CG  . ASP A 1 67  ? 143.335 124.895 132.278 1.00 73.13  ? 138 ASP F CG  1 
ATOM   328  O OD1 . ASP A 1 67  ? 144.518 124.814 131.884 1.00 73.13  ? 138 ASP F OD1 1 
ATOM   329  O OD2 . ASP A 1 67  ? 142.530 125.743 131.838 1.00 73.13  ? 138 ASP F OD2 1 
ATOM   330  N N   . ASP A 1 68  ? 146.040 123.206 135.151 1.00 72.20  ? 139 ASP F N   1 
ATOM   331  C CA  . ASP A 1 68  ? 147.105 123.796 135.961 1.00 72.20  ? 139 ASP F CA  1 
ATOM   332  C C   . ASP A 1 68  ? 146.603 124.301 137.311 1.00 72.20  ? 139 ASP F C   1 
ATOM   333  O O   . ASP A 1 68  ? 147.219 125.187 137.913 1.00 72.20  ? 139 ASP F O   1 
ATOM   334  C CB  . ASP A 1 68  ? 147.820 124.925 135.208 1.00 72.20  ? 139 ASP F CB  1 
ATOM   335  C CG  . ASP A 1 68  ? 148.515 124.437 133.952 1.00 72.20  ? 139 ASP F CG  1 
ATOM   336  O OD1 . ASP A 1 68  ? 148.404 123.233 133.638 1.00 72.20  ? 139 ASP F OD1 1 
ATOM   337  O OD2 . ASP A 1 68  ? 149.175 125.257 133.279 1.00 72.20  ? 139 ASP F OD2 1 
ATOM   338  N N   . ARG A 1 69  ? 145.493 123.755 137.801 1.00 75.12  ? 140 ARG F N   1 
ATOM   339  C CA  . ARG A 1 69  ? 144.963 124.083 139.117 1.00 75.12  ? 140 ARG F CA  1 
ATOM   340  C C   . ARG A 1 69  ? 144.802 122.798 139.914 1.00 75.12  ? 140 ARG F C   1 
ATOM   341  O O   . ARG A 1 69  ? 144.197 121.836 139.429 1.00 75.12  ? 140 ARG F O   1 
ATOM   342  C CB  . ARG A 1 69  ? 143.621 124.813 139.015 1.00 75.12  ? 140 ARG F CB  1 
ATOM   343  C CG  . ARG A 1 69  ? 143.137 125.392 140.335 1.00 75.12  ? 140 ARG F CG  1 
ATOM   344  C CD  . ARG A 1 69  ? 141.638 125.641 140.318 1.00 75.12  ? 140 ARG F CD  1 
ATOM   345  N NE  . ARG A 1 69  ? 140.884 124.393 140.300 1.00 75.12  ? 140 ARG F NE  1 
ATOM   346  C CZ  . ARG A 1 69  ? 140.527 123.720 141.385 1.00 75.12  ? 140 ARG F CZ  1 
ATOM   347  N NH1 . ARG A 1 69  ? 140.836 124.148 142.598 1.00 75.12  ? 140 ARG F NH1 1 
ATOM   348  N NH2 . ARG A 1 69  ? 139.842 122.587 141.250 1.00 75.12  ? 140 ARG F NH2 1 
ATOM   349  N N   . GLU A 1 70  ? 145.335 122.787 141.132 1.00 73.79  ? 141 GLU F N   1 
ATOM   350  C CA  . GLU A 1 70  ? 145.291 121.587 141.957 1.00 73.79  ? 141 GLU F CA  1 
ATOM   351  C C   . GLU A 1 70  ? 143.859 121.259 142.361 1.00 73.79  ? 141 GLU F C   1 
ATOM   352  O O   . GLU A 1 70  ? 143.079 122.142 142.730 1.00 73.79  ? 141 GLU F O   1 
ATOM   353  C CB  . GLU A 1 70  ? 146.161 121.767 143.201 1.00 73.79  ? 141 GLU F CB  1 
ATOM   354  C CG  . GLU A 1 70  ? 146.210 120.549 144.113 1.00 73.79  ? 141 GLU F CG  1 
ATOM   355  C CD  . GLU A 1 70  ? 146.887 119.355 143.465 1.00 73.79  ? 141 GLU F CD  1 
ATOM   356  O OE1 . GLU A 1 70  ? 147.719 119.558 142.555 1.00 73.79  ? 141 GLU F OE1 1 
ATOM   357  O OE2 . GLU A 1 70  ? 146.586 118.211 143.866 1.00 73.79  ? 141 GLU F OE2 1 
ATOM   358  N N   . ILE A 1 71  ? 143.517 119.976 142.289 1.00 74.51  ? 142 ILE F N   1 
ATOM   359  C CA  . ILE A 1 71  ? 142.200 119.490 142.685 1.00 74.51  ? 142 ILE F CA  1 
ATOM   360  C C   . ILE A 1 71  ? 142.270 119.129 144.165 1.00 74.51  ? 142 ILE F C   1 
ATOM   361  O O   . ILE A 1 71  ? 142.941 118.168 144.549 1.00 74.51  ? 142 ILE F O   1 
ATOM   362  C CB  . ILE A 1 71  ? 141.764 118.294 141.830 1.00 74.51  ? 142 ILE F CB  1 
ATOM   363  C CG1 . ILE A 1 71  ? 141.527 118.738 140.384 1.00 74.51  ? 142 ILE F CG1 1 
ATOM   364  C CG2 . ILE A 1 71  ? 140.518 117.644 142.407 1.00 74.51  ? 142 ILE F CG2 1 
ATOM   365  C CD1 . ILE A 1 71  ? 141.018 117.640 139.479 1.00 74.51  ? 142 ILE F CD1 1 
ATOM   366  N N   . THR A 1 72  ? 141.577 119.905 144.998 1.00 78.78  ? 143 THR F N   1 
ATOM   367  C CA  . THR A 1 72  ? 141.692 119.782 146.445 1.00 78.78  ? 143 THR F CA  1 
ATOM   368  C C   . THR A 1 72  ? 140.583 118.953 147.081 1.00 78.78  ? 143 THR F C   1 
ATOM   369  O O   . THR A 1 72  ? 140.745 118.512 148.224 1.00 78.78  ? 143 THR F O   1 
ATOM   370  C CB  . THR A 1 72  ? 141.710 121.172 147.093 1.00 78.78  ? 143 THR F CB  1 
ATOM   371  O OG1 . THR A 1 72  ? 140.510 121.877 146.753 1.00 78.78  ? 143 THR F OG1 1 
ATOM   372  C CG2 . THR A 1 72  ? 142.914 121.968 146.610 1.00 78.78  ? 143 THR F CG2 1 
ATOM   373  N N   . ASP A 1 73  ? 139.469 118.734 146.387 1.00 77.68  ? 144 ASP F N   1 
ATOM   374  C CA  . ASP A 1 73  ? 138.390 117.937 146.954 1.00 77.68  ? 144 ASP F CA  1 
ATOM   375  C C   . ASP A 1 73  ? 138.827 116.486 147.128 1.00 77.68  ? 144 ASP F C   1 
ATOM   376  O O   . ASP A 1 73  ? 139.549 115.925 146.300 1.00 77.68  ? 144 ASP F O   1 
ATOM   377  C CB  . ASP A 1 73  ? 137.142 118.009 146.074 1.00 77.68  ? 144 ASP F CB  1 
ATOM   378  C CG  . ASP A 1 73  ? 137.470 118.010 144.596 1.00 77.68  ? 144 ASP F CG  1 
ATOM   379  O OD1 . ASP A 1 73  ? 138.215 118.909 144.156 1.00 77.68  ? 144 ASP F OD1 1 
ATOM   380  O OD2 . ASP A 1 73  ? 136.987 117.110 143.876 1.00 77.68  ? 144 ASP F OD2 1 
ATOM   381  N N   . THR A 1 74  ? 138.378 115.880 148.223 1.00 71.40  ? 145 THR F N   1 
ATOM   382  C CA  . THR A 1 74  ? 138.772 114.517 148.580 1.00 71.40  ? 145 THR F CA  1 
ATOM   383  C C   . THR A 1 74  ? 137.882 113.476 147.907 1.00 71.40  ? 145 THR F C   1 
ATOM   384  O O   . THR A 1 74  ? 137.305 112.606 148.558 1.00 71.40  ? 145 THR F O   1 
ATOM   385  C CB  . THR A 1 74  ? 138.755 114.351 150.095 1.00 71.40  ? 145 THR F CB  1 
ATOM   386  O OG1 . THR A 1 74  ? 137.442 114.635 150.594 1.00 71.40  ? 145 THR F OG1 1 
ATOM   387  C CG2 . THR A 1 74  ? 139.755 115.296 150.745 1.00 71.40  ? 145 THR F CG2 1 
ATOM   388  N N   . LEU A 1 75  ? 137.767 113.562 146.584 1.00 64.02  ? 146 LEU F N   1 
ATOM   389  C CA  . LEU A 1 75  ? 137.030 112.583 145.799 1.00 64.02  ? 146 LEU F CA  1 
ATOM   390  C C   . LEU A 1 75  ? 137.926 111.493 145.227 1.00 64.02  ? 146 LEU F C   1 
ATOM   391  O O   . LEU A 1 75  ? 137.428 110.602 144.531 1.00 64.02  ? 146 LEU F O   1 
ATOM   392  C CB  . LEU A 1 75  ? 136.272 113.278 144.662 1.00 64.02  ? 146 LEU F CB  1 
ATOM   393  C CG  . LEU A 1 75  ? 135.183 114.267 145.082 1.00 64.02  ? 146 LEU F CG  1 
ATOM   394  C CD1 . LEU A 1 75  ? 134.495 114.859 143.862 1.00 64.02  ? 146 LEU F CD1 1 
ATOM   395  C CD2 . LEU A 1 75  ? 134.172 113.595 145.999 1.00 64.02  ? 146 LEU F CD2 1 
ATOM   396  N N   . ALA A 1 76  ? 139.227 111.542 145.500 1.00 60.13  ? 147 ALA F N   1 
ATOM   397  C CA  . ALA A 1 76  ? 140.140 110.526 144.997 1.00 60.13  ? 147 ALA F CA  1 
ATOM   398  C C   . ALA A 1 76  ? 139.894 109.192 145.690 1.00 60.13  ? 147 ALA F C   1 
ATOM   399  O O   . ALA A 1 76  ? 139.666 109.134 146.902 1.00 60.13  ? 147 ALA F O   1 
ATOM   400  C CB  . ALA A 1 76  ? 141.589 110.965 145.199 1.00 60.13  ? 147 ALA F CB  1 
ATOM   401  N N   . GLN A 1 77  ? 139.942 108.115 144.911 1.00 55.76  ? 148 GLN F N   1 
ATOM   402  C CA  . GLN A 1 77  ? 139.734 106.756 145.400 1.00 55.76  ? 148 GLN F CA  1 
ATOM   403  C C   . GLN A 1 77  ? 140.891 105.862 144.967 1.00 55.76  ? 148 GLN F C   1 
ATOM   404  O O   . GLN A 1 77  ? 140.705 104.786 144.394 1.00 55.76  ? 148 GLN F O   1 
ATOM   405  C CB  . GLN A 1 77  ? 138.393 106.204 144.922 1.00 55.76  ? 148 GLN F CB  1 
ATOM   406  C CG  . GLN A 1 77  ? 137.901 104.991 145.704 1.00 55.76  ? 148 GLN F CG  1 
ATOM   407  C CD  . GLN A 1 77  ? 136.515 104.546 145.282 1.00 55.76  ? 148 GLN F CD  1 
ATOM   408  O OE1 . GLN A 1 77  ? 135.564 105.328 145.308 1.00 55.76  ? 148 GLN F OE1 1 
ATOM   409  N NE2 . GLN A 1 77  ? 136.393 103.283 144.889 1.00 55.76  ? 148 GLN F NE2 1 
ATOM   410  N N   . THR A 1 78  ? 142.116 106.327 145.213 1.00 51.69  ? 149 THR F N   1 
ATOM   411  C CA  . THR A 1 78  ? 143.313 105.565 144.878 1.00 51.69  ? 149 THR F CA  1 
ATOM   412  C C   . THR A 1 78  ? 143.328 104.224 145.603 1.00 51.69  ? 149 THR F C   1 
ATOM   413  O O   . THR A 1 78  ? 143.434 104.175 146.832 1.00 51.69  ? 149 THR F O   1 
ATOM   414  C CB  . THR A 1 78  ? 144.572 106.365 145.224 1.00 51.69  ? 149 THR F CB  1 
ATOM   415  O OG1 . THR A 1 78  ? 144.603 107.570 144.448 1.00 51.69  ? 149 THR F OG1 1 
ATOM   416  C CG2 . THR A 1 78  ? 145.820 105.548 144.933 1.00 51.69  ? 149 THR F CG2 1 
ATOM   417  N N   . VAL A 1 79  ? 143.221 103.134 144.847 1.00 61.30  ? 150 VAL F N   1 
ATOM   418  C CA  . VAL A 1 79  ? 143.180 101.783 145.394 1.00 61.30  ? 150 VAL F CA  1 
ATOM   419  C C   . VAL A 1 79  ? 144.221 100.937 144.674 1.00 61.30  ? 150 VAL F C   1 
ATOM   420  O O   . VAL A 1 79  ? 144.385 101.043 143.454 1.00 61.30  ? 150 VAL F O   1 
ATOM   421  C CB  . VAL A 1 79  ? 141.775 101.155 145.258 1.00 61.30  ? 150 VAL F CB  1 
ATOM   422  C CG1 . VAL A 1 79  ? 141.771 99.721  145.768 1.00 61.30  ? 150 VAL F CG1 1 
ATOM   423  C CG2 . VAL A 1 79  ? 140.743 101.985 146.006 1.00 61.30  ? 150 VAL F CG2 1 
ATOM   424  N N   . LEU A 1 80  ? 144.933 100.108 145.433 1.00 71.03  ? 151 LEU F N   1 
ATOM   425  C CA  . LEU A 1 80  ? 145.923 99.206  144.859 1.00 71.03  ? 151 LEU F CA  1 
ATOM   426  C C   . LEU A 1 80  ? 145.217 98.038  144.179 1.00 71.03  ? 151 LEU F C   1 
ATOM   427  O O   . LEU A 1 80  ? 144.466 97.299  144.824 1.00 71.03  ? 151 LEU F O   1 
ATOM   428  C CB  . LEU A 1 80  ? 146.873 98.705  145.944 1.00 71.03  ? 151 LEU F CB  1 
ATOM   429  C CG  . LEU A 1 80  ? 147.882 97.633  145.533 1.00 71.03  ? 151 LEU F CG  1 
ATOM   430  C CD1 . LEU A 1 80  ? 148.852 98.174  144.494 1.00 71.03  ? 151 LEU F CD1 1 
ATOM   431  C CD2 . LEU A 1 80  ? 148.626 97.112  146.751 1.00 71.03  ? 151 LEU F CD2 1 
ATOM   432  N N   . ILE A 1 81  ? 145.457 97.871  142.877 1.00 79.99  ? 152 ILE F N   1 
ATOM   433  C CA  . ILE A 1 81  ? 144.850 96.761  142.148 1.00 79.99  ? 152 ILE F CA  1 
ATOM   434  C C   . ILE A 1 81  ? 145.606 95.467  142.423 1.00 79.99  ? 152 ILE F C   1 
ATOM   435  O O   . ILE A 1 81  ? 145.033 94.482  142.903 1.00 79.99  ? 152 ILE F O   1 
ATOM   436  C CB  . ILE A 1 81  ? 144.797 97.066  140.641 1.00 79.99  ? 152 ILE F CB  1 
ATOM   437  C CG1 . ILE A 1 81  ? 143.797 98.184  140.351 1.00 79.99  ? 152 ILE F CG1 1 
ATOM   438  C CG2 . ILE A 1 81  ? 144.435 95.813  139.856 1.00 79.99  ? 152 ILE F CG2 1 
ATOM   439  C CD1 . ILE A 1 81  ? 143.623 98.476  138.876 1.00 79.99  ? 152 ILE F CD1 1 
ATOM   440  N N   . LYS A 1 82  ? 146.902 95.451  142.123 1.00 88.19  ? 153 LYS F N   1 
ATOM   441  C CA  . LYS A 1 82  ? 147.699 94.239  142.248 1.00 88.19  ? 153 LYS F CA  1 
ATOM   442  C C   . LYS A 1 82  ? 149.165 94.621  142.375 1.00 88.19  ? 153 LYS F C   1 
ATOM   443  O O   . LYS A 1 82  ? 149.567 95.741  142.047 1.00 88.19  ? 153 LYS F O   1 
ATOM   444  C CB  . LYS A 1 82  ? 147.487 93.309  141.049 1.00 88.19  ? 153 LYS F CB  1 
ATOM   445  C CG  . LYS A 1 82  ? 147.762 93.972  139.708 1.00 88.19  ? 153 LYS F CG  1 
ATOM   446  C CD  . LYS A 1 82  ? 147.511 93.022  138.551 1.00 88.19  ? 153 LYS F CD  1 
ATOM   447  C CE  . LYS A 1 82  ? 147.725 93.717  137.216 1.00 88.19  ? 153 LYS F CE  1 
ATOM   448  N NZ  . LYS A 1 82  ? 146.803 94.873  137.039 1.00 88.19  ? 153 LYS F NZ  1 
ATOM   449  N N   . GLU A 1 83  ? 149.958 93.669  142.863 1.00 95.99  ? 154 GLU F N   1 
ATOM   450  C CA  . GLU A 1 83  ? 151.399 93.832  142.993 1.00 95.99  ? 154 GLU F CA  1 
ATOM   451  C C   . GLU A 1 83  ? 152.094 92.611  142.414 1.00 95.99  ? 154 GLU F C   1 
ATOM   452  O O   . GLU A 1 83  ? 151.740 91.475  142.744 1.00 95.99  ? 154 GLU F O   1 
ATOM   453  C CB  . GLU A 1 83  ? 151.809 94.029  144.457 1.00 95.99  ? 154 GLU F CB  1 
ATOM   454  C CG  . GLU A 1 83  ? 151.386 95.361  145.052 1.00 95.99  ? 154 GLU F CG  1 
ATOM   455  C CD  . GLU A 1 83  ? 151.857 95.533  146.483 1.00 95.99  ? 154 GLU F CD  1 
ATOM   456  O OE1 . GLU A 1 83  ? 152.235 94.522  147.111 1.00 95.99  ? 154 GLU F OE1 1 
ATOM   457  O OE2 . GLU A 1 83  ? 151.854 96.679  146.979 1.00 95.99  ? 154 GLU F OE2 1 
ATOM   458  N N   . GLU A 1 84  ? 153.079 92.848  141.552 1.00 103.69 ? 155 GLU F N   1 
ATOM   459  C CA  . GLU A 1 84  ? 153.909 91.802  140.970 1.00 103.69 ? 155 GLU F CA  1 
ATOM   460  C C   . GLU A 1 84  ? 155.371 92.025  141.337 1.00 103.69 ? 155 GLU F C   1 
ATOM   461  O O   . GLU A 1 84  ? 156.274 91.867  140.511 1.00 103.69 ? 155 GLU F O   1 
ATOM   462  C CB  . GLU A 1 84  ? 153.733 91.746  139.454 1.00 103.69 ? 155 GLU F CB  1 
ATOM   463  C CG  . GLU A 1 84  ? 152.284 91.662  138.994 1.00 103.69 ? 155 GLU F CG  1 
ATOM   464  C CD  . GLU A 1 84  ? 151.620 90.350  139.368 1.00 103.69 ? 155 GLU F CD  1 
ATOM   465  O OE1 . GLU A 1 84  ? 152.342 89.352  139.581 1.00 103.69 ? 155 GLU F OE1 1 
ATOM   466  O OE2 . GLU A 1 84  ? 150.374 90.316  139.448 1.00 103.69 ? 155 GLU F OE2 1 
ATOM   467  N N   . GLY A 1 85  ? 155.616 92.398  142.590 1.00 103.11 ? 156 GLY F N   1 
ATOM   468  C CA  . GLY A 1 85  ? 156.938 92.800  143.025 1.00 103.11 ? 156 GLY F CA  1 
ATOM   469  C C   . GLY A 1 85  ? 157.002 94.298  143.241 1.00 103.11 ? 156 GLY F C   1 
ATOM   470  O O   . GLY A 1 85  ? 156.236 94.847  144.038 1.00 103.11 ? 156 GLY F O   1 
ATOM   471  N N   . LYS A 1 86  ? 157.911 94.973  142.538 1.00 98.33  ? 157 LYS F N   1 
ATOM   472  C CA  . LYS A 1 86  ? 157.940 96.429  142.560 1.00 98.33  ? 157 LYS F CA  1 
ATOM   473  C C   . LYS A 1 86  ? 156.890 97.048  141.648 1.00 98.33  ? 157 LYS F C   1 
ATOM   474  O O   . LYS A 1 86  ? 156.639 98.254  141.747 1.00 98.33  ? 157 LYS F O   1 
ATOM   475  C CB  . LYS A 1 86  ? 159.328 96.939  142.163 1.00 98.33  ? 157 LYS F CB  1 
ATOM   476  C CG  . LYS A 1 86  ? 159.729 96.607  140.735 1.00 98.33  ? 157 LYS F CG  1 
ATOM   477  C CD  . LYS A 1 86  ? 161.056 97.255  140.374 1.00 98.33  ? 157 LYS F CD  1 
ATOM   478  C CE  . LYS A 1 86  ? 160.983 98.768  140.505 1.00 98.33  ? 157 LYS F CE  1 
ATOM   479  N NZ  . LYS A 1 86  ? 162.277 99.420  140.165 1.00 98.33  ? 157 LYS F NZ  1 
ATOM   480  N N   . LEU A 1 87  ? 156.275 96.257  140.771 1.00 95.70  ? 158 LEU F N   1 
ATOM   481  C CA  . LEU A 1 87  ? 155.238 96.738  139.861 1.00 95.70  ? 158 LEU F CA  1 
ATOM   482  C C   . LEU A 1 87  ? 153.901 96.683  140.588 1.00 95.70  ? 158 LEU F C   1 
ATOM   483  O O   . LEU A 1 87  ? 153.300 95.616  140.731 1.00 95.70  ? 158 LEU F O   1 
ATOM   484  C CB  . LEU A 1 87  ? 155.217 95.905  138.584 1.00 95.70  ? 158 LEU F CB  1 
ATOM   485  C CG  . LEU A 1 87  ? 154.065 96.153  137.607 1.00 95.70  ? 158 LEU F CG  1 
ATOM   486  C CD1 . LEU A 1 87  ? 154.070 97.591  137.121 1.00 95.70  ? 158 LEU F CD1 1 
ATOM   487  C CD2 . LEU A 1 87  ? 154.139 95.188  136.434 1.00 95.70  ? 158 LEU F CD2 1 
ATOM   488  N N   . ALA A 1 88  ? 153.434 97.837  141.056 1.00 83.78  ? 159 ALA F N   1 
ATOM   489  C CA  . ALA A 1 88  ? 152.152 97.953  141.742 1.00 83.78  ? 159 ALA F CA  1 
ATOM   490  C C   . ALA A 1 88  ? 151.192 98.710  140.833 1.00 83.78  ? 159 ALA F C   1 
ATOM   491  O O   . ALA A 1 88  ? 151.371 99.908  140.590 1.00 83.78  ? 159 ALA F O   1 
ATOM   492  C CB  . ALA A 1 88  ? 152.312 98.657  143.088 1.00 83.78  ? 159 ALA F CB  1 
ATOM   493  N N   . SER A 1 89  ? 150.176 98.010  140.333 1.00 75.73  ? 160 SER F N   1 
ATOM   494  C CA  . SER A 1 89  ? 149.182 98.628  139.462 1.00 75.73  ? 160 SER F CA  1 
ATOM   495  C C   . SER A 1 89  ? 148.269 99.515  140.299 1.00 75.73  ? 160 SER F C   1 
ATOM   496  O O   . SER A 1 89  ? 147.482 99.016  141.110 1.00 75.73  ? 160 SER F O   1 
ATOM   497  C CB  . SER A 1 89  ? 148.382 97.554  138.731 1.00 75.73  ? 160 SER F CB  1 
ATOM   498  O OG  . SER A 1 89  ? 149.230 96.726  137.955 1.00 75.73  ? 160 SER F OG  1 
ATOM   499  N N   . THR A 1 90  ? 148.366 100.828 140.108 1.00 60.27  ? 161 THR F N   1 
ATOM   500  C CA  . THR A 1 90  ? 147.607 101.787 140.901 1.00 60.27  ? 161 THR F CA  1 
ATOM   501  C C   . THR A 1 90  ? 146.470 102.360 140.066 1.00 60.27  ? 161 THR F C   1 
ATOM   502  O O   . THR A 1 90  ? 146.692 102.806 138.938 1.00 60.27  ? 161 THR F O   1 
ATOM   503  C CB  . THR A 1 90  ? 148.510 102.915 141.405 1.00 60.27  ? 161 THR F CB  1 
ATOM   504  O OG1 . THR A 1 90  ? 149.551 102.367 142.224 1.00 60.27  ? 161 THR F OG1 1 
ATOM   505  C CG2 . THR A 1 90  ? 147.709 103.919 142.219 1.00 60.27  ? 161 THR F CG2 1 
ATOM   506  N N   . CYS A 1 91  ? 145.258 102.347 140.616 1.00 56.73  ? 162 CYS F N   1 
ATOM   507  C CA  . CYS A 1 91  ? 144.102 102.955 139.960 1.00 56.73  ? 162 CYS F CA  1 
ATOM   508  C C   . CYS A 1 91  ? 143.649 104.146 140.800 1.00 56.73  ? 162 CYS F C   1 
ATOM   509  O O   . CYS A 1 91  ? 143.069 103.980 141.877 1.00 56.73  ? 162 CYS F O   1 
ATOM   510  C CB  . CYS A 1 91  ? 142.977 101.940 139.748 1.00 56.73  ? 162 CYS F CB  1 
ATOM   511  S SG  . CYS A 1 91  ? 142.253 101.194 141.231 1.00 56.73  ? 162 CYS F SG  1 
ATOM   512  N N   . SER A 1 92  ? 143.936 105.348 140.312 1.00 54.52  ? 163 SER F N   1 
ATOM   513  C CA  . SER A 1 92  ? 143.441 106.571 140.927 1.00 54.52  ? 163 SER F CA  1 
ATOM   514  C C   . SER A 1 92  ? 142.154 106.974 140.219 1.00 54.52  ? 163 SER F C   1 
ATOM   515  O O   . SER A 1 92  ? 142.163 107.236 139.011 1.00 54.52  ? 163 SER F O   1 
ATOM   516  C CB  . SER A 1 92  ? 144.484 107.685 140.842 1.00 54.52  ? 163 SER F CB  1 
ATOM   517  O OG  . SER A 1 92  ? 144.042 108.850 141.516 1.00 54.52  ? 163 SER F OG  1 
ATOM   518  N N   . LYS A 1 93  ? 141.051 107.002 140.963 1.00 50.52  ? 164 LYS F N   1 
ATOM   519  C CA  . LYS A 1 93  ? 139.735 107.294 140.408 1.00 50.52  ? 164 LYS F CA  1 
ATOM   520  C C   . LYS A 1 93  ? 139.364 108.729 140.759 1.00 50.52  ? 164 LYS F C   1 
ATOM   521  O O   . LYS A 1 93  ? 139.197 109.066 141.936 1.00 50.52  ? 164 LYS F O   1 
ATOM   522  C CB  . LYS A 1 93  ? 138.691 106.309 140.932 1.00 50.52  ? 164 LYS F CB  1 
ATOM   523  C CG  . LYS A 1 93  ? 137.339 106.411 140.240 1.00 50.52  ? 164 LYS F CG  1 
ATOM   524  C CD  . LYS A 1 93  ? 136.332 107.202 141.060 1.00 50.52  ? 164 LYS F CD  1 
ATOM   525  C CE  . LYS A 1 93  ? 135.896 106.426 142.290 1.00 50.52  ? 164 LYS F CE  1 
ATOM   526  N NZ  . LYS A 1 93  ? 134.869 107.158 143.081 1.00 50.52  ? 164 LYS F NZ  1 
ATOM   527  N N   . LEU A 1 94  ? 139.237 109.570 139.738 1.00 56.40  ? 165 LEU F N   1 
ATOM   528  C CA  . LEU A 1 94  ? 138.822 110.956 139.908 1.00 56.40  ? 165 LEU F CA  1 
ATOM   529  C C   . LEU A 1 94  ? 137.382 111.103 139.433 1.00 56.40  ? 165 LEU F C   1 
ATOM   530  O O   . LEU A 1 94  ? 137.060 110.738 138.297 1.00 56.40  ? 165 LEU F O   1 
ATOM   531  C CB  . LEU A 1 94  ? 139.738 111.906 139.138 1.00 56.40  ? 165 LEU F CB  1 
ATOM   532  C CG  . LEU A 1 94  ? 139.367 113.387 139.244 1.00 56.40  ? 165 LEU F CG  1 
ATOM   533  C CD1 . LEU A 1 94  ? 139.502 113.874 140.679 1.00 56.40  ? 165 LEU F CD1 1 
ATOM   534  C CD2 . LEU A 1 94  ? 140.213 114.230 138.305 1.00 56.40  ? 165 LEU F CD2 1 
ATOM   535  N N   . ASN A 1 95  ? 136.523 111.633 140.300 1.00 58.41  ? 166 ASN F N   1 
ATOM   536  C CA  . ASN A 1 95  ? 135.121 111.860 139.971 1.00 58.41  ? 166 ASN F CA  1 
ATOM   537  C C   . ASN A 1 95  ? 134.975 113.283 139.443 1.00 58.41  ? 166 ASN F C   1 
ATOM   538  O O   . ASN A 1 95  ? 135.097 114.250 140.203 1.00 58.41  ? 166 ASN F O   1 
ATOM   539  C CB  . ASN A 1 95  ? 134.236 111.632 141.194 1.00 58.41  ? 166 ASN F CB  1 
ATOM   540  C CG  . ASN A 1 95  ? 134.411 110.250 141.790 1.00 58.41  ? 166 ASN F CG  1 
ATOM   541  O OD1 . ASN A 1 95  ? 133.723 109.304 141.407 1.00 58.41  ? 166 ASN F OD1 1 
ATOM   542  N ND2 . ASN A 1 95  ? 135.337 110.126 142.734 1.00 58.41  ? 166 ASN F ND2 1 
ATOM   543  N N   . ILE A 1 96  ? 134.715 113.412 138.145 1.00 58.42  ? 167 ILE F N   1 
ATOM   544  C CA  . ILE A 1 96  ? 134.603 114.710 137.489 1.00 58.42  ? 167 ILE F CA  1 
ATOM   545  C C   . ILE A 1 96  ? 133.167 114.909 137.027 1.00 58.42  ? 167 ILE F C   1 
ATOM   546  O O   . ILE A 1 96  ? 132.556 113.999 136.457 1.00 58.42  ? 167 ILE F O   1 
ATOM   547  C CB  . ILE A 1 96  ? 135.580 114.832 136.303 1.00 58.42  ? 167 ILE F CB  1 
ATOM   548  C CG1 . ILE A 1 96  ? 135.486 113.595 135.408 1.00 58.42  ? 167 ILE F CG1 1 
ATOM   549  C CG2 . ILE A 1 96  ? 137.000 115.035 136.800 1.00 58.42  ? 167 ILE F CG2 1 
ATOM   550  C CD1 . ILE A 1 96  ? 136.334 113.669 134.168 1.00 58.42  ? 167 ILE F CD1 1 
ATOM   551  N N   . THR A 1 97  ? 132.628 116.098 137.276 1.00 60.30  ? 168 THR F N   1 
ATOM   552  C CA  . THR A 1 97  ? 131.291 116.407 136.798 1.00 60.30  ? 168 THR F CA  1 
ATOM   553  C C   . THR A 1 97  ? 131.281 116.480 135.273 1.00 60.30  ? 168 THR F C   1 
ATOM   554  O O   . THR A 1 97  ? 132.316 116.655 134.623 1.00 60.30  ? 168 THR F O   1 
ATOM   555  C CB  . THR A 1 97  ? 130.791 117.724 137.392 1.00 60.30  ? 168 THR F CB  1 
ATOM   556  O OG1 . THR A 1 97  ? 131.630 118.799 136.952 1.00 60.30  ? 168 THR F OG1 1 
ATOM   557  C CG2 . THR A 1 97  ? 130.809 117.664 138.912 1.00 60.30  ? 168 THR F CG2 1 
ATOM   558  N N   . GLU A 1 98  ? 130.083 116.330 134.702 1.00 53.16  ? 169 GLU F N   1 
ATOM   559  C CA  . GLU A 1 98  ? 129.950 116.339 133.248 1.00 53.16  ? 169 GLU F CA  1 
ATOM   560  C C   . GLU A 1 98  ? 130.406 117.668 132.660 1.00 53.16  ? 169 GLU F C   1 
ATOM   561  O O   . GLU A 1 98  ? 131.028 117.703 131.591 1.00 53.16  ? 169 GLU F O   1 
ATOM   562  C CB  . GLU A 1 98  ? 128.503 116.041 132.854 1.00 53.16  ? 169 GLU F CB  1 
ATOM   563  C CG  . GLU A 1 98  ? 128.276 115.927 131.355 1.00 53.16  ? 169 GLU F CG  1 
ATOM   564  C CD  . GLU A 1 98  ? 126.841 115.580 131.010 1.00 53.16  ? 169 GLU F CD  1 
ATOM   565  O OE1 . GLU A 1 98  ? 126.018 115.456 131.941 1.00 53.16  ? 169 GLU F OE1 1 
ATOM   566  O OE2 . GLU A 1 98  ? 126.535 115.431 129.808 1.00 53.16  ? 169 GLU F OE2 1 
ATOM   567  N N   . GLN A 1 99  ? 130.105 118.775 133.345 1.00 54.86  ? 170 GLN F N   1 
ATOM   568  C CA  . GLN A 1 99  ? 130.526 120.086 132.861 1.00 54.86  ? 170 GLN F CA  1 
ATOM   569  C C   . GLN A 1 99  ? 132.045 120.193 132.804 1.00 54.86  ? 170 GLN F C   1 
ATOM   570  O O   . GLN A 1 99  ? 132.600 120.719 131.833 1.00 54.86  ? 170 GLN F O   1 
ATOM   571  C CB  . GLN A 1 99  ? 129.948 121.189 133.750 1.00 54.86  ? 170 GLN F CB  1 
ATOM   572  C CG  . GLN A 1 99  ? 128.426 121.246 133.791 1.00 54.86  ? 170 GLN F CG  1 
ATOM   573  C CD  . GLN A 1 99  ? 127.820 120.218 134.729 1.00 54.86  ? 170 GLN F CD  1 
ATOM   574  O OE1 . GLN A 1 99  ? 128.534 119.508 135.437 1.00 54.86  ? 170 GLN F OE1 1 
ATOM   575  N NE2 . GLN A 1 99  ? 126.494 120.135 134.737 1.00 54.86  ? 170 GLN F NE2 1 
ATOM   576  N N   . GLN A 1 100 ? 132.734 119.702 133.837 1.00 61.34  ? 171 GLN F N   1 
ATOM   577  C CA  . GLN A 1 100 ? 134.192 119.767 133.857 1.00 61.34  ? 171 GLN F CA  1 
ATOM   578  C C   . GLN A 1 100 ? 134.799 118.921 132.744 1.00 61.34  ? 171 GLN F C   1 
ATOM   579  O O   . GLN A 1 100 ? 135.752 119.340 132.077 1.00 61.34  ? 171 GLN F O   1 
ATOM   580  C CB  . GLN A 1 100 ? 134.718 119.319 135.222 1.00 61.34  ? 171 GLN F CB  1 
ATOM   581  C CG  . GLN A 1 100 ? 134.402 120.276 136.359 1.00 61.34  ? 171 GLN F CG  1 
ATOM   582  C CD  . GLN A 1 100 ? 134.842 119.740 137.708 1.00 61.34  ? 171 GLN F CD  1 
ATOM   583  O OE1 . GLN A 1 100 ? 135.257 118.587 137.825 1.00 61.34  ? 171 GLN F OE1 1 
ATOM   584  N NE2 . GLN A 1 100 ? 134.752 120.577 138.735 1.00 61.34  ? 171 GLN F NE2 1 
ATOM   585  N N   . TRP A 1 101 ? 134.260 117.718 132.533 1.00 57.13  ? 172 TRP F N   1 
ATOM   586  C CA  . TRP A 1 101 ? 134.816 116.825 131.521 1.00 57.13  ? 172 TRP F CA  1 
ATOM   587  C C   . TRP A 1 101 ? 134.550 117.346 130.114 1.00 57.13  ? 172 TRP F C   1 
ATOM   588  O O   . TRP A 1 101 ? 135.391 117.207 129.218 1.00 57.13  ? 172 TRP F O   1 
ATOM   589  C CB  . TRP A 1 101 ? 134.249 115.416 131.695 1.00 57.13  ? 172 TRP F CB  1 
ATOM   590  C CG  . TRP A 1 101 ? 134.673 114.464 130.618 1.00 57.13  ? 172 TRP F CG  1 
ATOM   591  C CD1 . TRP A 1 101 ? 133.863 113.816 129.732 1.00 57.13  ? 172 TRP F CD1 1 
ATOM   592  C CD2 . TRP A 1 101 ? 136.013 114.064 130.303 1.00 57.13  ? 172 TRP F CD2 1 
ATOM   593  N NE1 . TRP A 1 101 ? 134.613 113.031 128.891 1.00 57.13  ? 172 TRP F NE1 1 
ATOM   594  C CE2 . TRP A 1 101 ? 135.936 113.165 129.221 1.00 57.13  ? 172 TRP F CE2 1 
ATOM   595  C CE3 . TRP A 1 101 ? 137.269 114.375 130.833 1.00 57.13  ? 172 TRP F CE3 1 
ATOM   596  C CZ2 . TRP A 1 101 ? 137.066 112.579 128.657 1.00 57.13  ? 172 TRP F CZ2 1 
ATOM   597  C CZ3 . TRP A 1 101 ? 138.390 113.788 130.274 1.00 57.13  ? 172 TRP F CZ3 1 
ATOM   598  C CH2 . TRP A 1 101 ? 138.281 112.900 129.197 1.00 57.13  ? 172 TRP F CH2 1 
ATOM   599  N N   . MET A 1 102 ? 133.381 117.951 129.898 1.00 56.75  ? 173 MET F N   1 
ATOM   600  C CA  . MET A 1 102 ? 133.021 118.448 128.577 1.00 56.75  ? 173 MET F CA  1 
ATOM   601  C C   . MET A 1 102 ? 133.457 119.888 128.338 1.00 56.75  ? 173 MET F C   1 
ATOM   602  O O   . MET A 1 102 ? 133.135 120.445 127.283 1.00 56.75  ? 173 MET F O   1 
ATOM   603  C CB  . MET A 1 102 ? 131.511 118.323 128.361 1.00 56.75  ? 173 MET F CB  1 
ATOM   604  C CG  . MET A 1 102 ? 131.022 116.888 128.258 1.00 56.75  ? 173 MET F CG  1 
ATOM   605  S SD  . MET A 1 102 ? 129.264 116.769 127.878 1.00 56.75  ? 173 MET F SD  1 
ATOM   606  C CE  . MET A 1 102 ? 129.071 114.994 127.735 1.00 56.75  ? 173 MET F CE  1 
ATOM   607  N N   . SER A 1 103 ? 134.172 120.502 129.280 1.00 59.37  ? 174 SER F N   1 
ATOM   608  C CA  . SER A 1 103 ? 134.641 121.872 129.114 1.00 59.37  ? 174 SER F CA  1 
ATOM   609  C C   . SER A 1 103 ? 135.963 121.915 128.357 1.00 59.37  ? 174 SER F C   1 
ATOM   610  O O   . SER A 1 103 ? 136.601 122.970 128.278 1.00 59.37  ? 174 SER F O   1 
ATOM   611  C CB  . SER A 1 103 ? 134.792 122.558 130.474 1.00 59.37  ? 174 SER F CB  1 
ATOM   612  O OG  . SER A 1 103 ? 135.720 121.870 131.294 1.00 59.37  ? 174 SER F OG  1 
ATOM   613  N N   . GLU A 1 104 ? 136.377 120.773 127.802 1.00 61.63  ? 175 GLU F N   1 
ATOM   614  C CA  . GLU A 1 104 ? 137.649 120.651 127.085 1.00 61.63  ? 175 GLU F CA  1 
ATOM   615  C C   . GLU A 1 104 ? 138.817 121.061 127.980 1.00 61.63  ? 175 GLU F C   1 
ATOM   616  O O   . GLU A 1 104 ? 139.662 121.879 127.611 1.00 61.63  ? 175 GLU F O   1 
ATOM   617  C CB  . GLU A 1 104 ? 137.632 121.462 125.787 1.00 61.63  ? 175 GLU F CB  1 
ATOM   618  C CG  . GLU A 1 104 ? 136.522 121.066 124.827 1.00 61.63  ? 175 GLU F CG  1 
ATOM   619  C CD  . GLU A 1 104 ? 136.497 121.923 123.576 1.00 61.63  ? 175 GLU F CD  1 
ATOM   620  O OE1 . GLU A 1 104 ? 137.350 122.827 123.456 1.00 61.63  ? 175 GLU F OE1 1 
ATOM   621  O OE2 . GLU A 1 104 ? 135.623 121.692 122.714 1.00 61.63  ? 175 GLU F OE2 1 
ATOM   622  N N   . SER A 1 105 ? 138.857 120.476 129.174 1.00 63.05  ? 176 SER F N   1 
ATOM   623  C CA  . SER A 1 105 ? 139.862 120.808 130.174 1.00 63.05  ? 176 SER F CA  1 
ATOM   624  C C   . SER A 1 105 ? 141.169 120.081 129.860 1.00 63.05  ? 176 SER F C   1 
ATOM   625  O O   . SER A 1 105 ? 141.367 119.540 128.769 1.00 63.05  ? 176 SER F O   1 
ATOM   626  C CB  . SER A 1 105 ? 139.344 120.473 131.570 1.00 63.05  ? 176 SER F CB  1 
ATOM   627  O OG  . SER A 1 105 ? 139.055 119.092 131.686 1.00 63.05  ? 176 SER F OG  1 
ATOM   628  N N   . THR A 1 106 ? 142.085 120.077 130.823 1.00 63.46  ? 177 THR F N   1 
ATOM   629  C CA  . THR A 1 106 ? 143.407 119.470 130.697 1.00 63.46  ? 177 THR F CA  1 
ATOM   630  C C   . THR A 1 106 ? 143.690 118.585 131.906 1.00 63.46  ? 177 THR F C   1 
ATOM   631  O O   . THR A 1 106 ? 144.703 118.732 132.592 1.00 63.46  ? 177 THR F O   1 
ATOM   632  C CB  . THR A 1 106 ? 144.487 120.538 130.534 1.00 63.46  ? 177 THR F CB  1 
ATOM   633  O OG1 . THR A 1 106 ? 143.988 121.598 129.709 1.00 63.46  ? 177 THR F OG1 1 
ATOM   634  C CG2 . THR A 1 106 ? 145.727 119.946 129.874 1.00 63.46  ? 177 THR F CG2 1 
ATOM   635  N N   . PHE A 1 107 ? 142.761 117.671 132.197 1.00 60.51  ? 178 PHE F N   1 
ATOM   636  C CA  . PHE A 1 107 ? 142.819 116.897 133.434 1.00 60.51  ? 178 PHE F CA  1 
ATOM   637  C C   . PHE A 1 107 ? 144.140 116.147 133.536 1.00 60.51  ? 178 PHE F C   1 
ATOM   638  O O   . PHE A 1 107 ? 144.434 115.274 132.716 1.00 60.51  ? 178 PHE F O   1 
ATOM   639  C CB  . PHE A 1 107 ? 141.645 115.923 133.497 1.00 60.51  ? 178 PHE F CB  1 
ATOM   640  C CG  . PHE A 1 107 ? 140.326 116.581 133.783 1.00 60.51  ? 178 PHE F CG  1 
ATOM   641  C CD1 . PHE A 1 107 ? 140.253 117.681 134.621 1.00 60.51  ? 178 PHE F CD1 1 
ATOM   642  C CD2 . PHE A 1 107 ? 139.159 116.103 133.211 1.00 60.51  ? 178 PHE F CD2 1 
ATOM   643  C CE1 . PHE A 1 107 ? 139.040 118.288 134.886 1.00 60.51  ? 178 PHE F CE1 1 
ATOM   644  C CE2 . PHE A 1 107 ? 137.944 116.708 133.471 1.00 60.51  ? 178 PHE F CE2 1 
ATOM   645  C CZ  . PHE A 1 107 ? 137.885 117.801 134.311 1.00 60.51  ? 178 PHE F CZ  1 
ATOM   646  N N   . THR A 1 108 ? 144.938 116.491 134.542 1.00 68.41  ? 179 THR F N   1 
ATOM   647  C CA  . THR A 1 108 ? 146.307 116.010 134.658 1.00 68.41  ? 179 THR F CA  1 
ATOM   648  C C   . THR A 1 108 ? 146.431 115.090 135.864 1.00 68.41  ? 179 THR F C   1 
ATOM   649  O O   . THR A 1 108 ? 146.081 115.476 136.985 1.00 68.41  ? 179 THR F O   1 
ATOM   650  C CB  . THR A 1 108 ? 147.284 117.180 134.779 1.00 68.41  ? 179 THR F CB  1 
ATOM   651  O OG1 . THR A 1 108 ? 147.147 118.039 133.640 1.00 68.41  ? 179 THR F OG1 1 
ATOM   652  C CG2 . THR A 1 108 ? 148.712 116.671 134.855 1.00 68.41  ? 179 THR F CG2 1 
ATOM   653  N N   . CYS A 1 109 ? 146.930 113.881 135.627 1.00 66.79  ? 180 CYS F N   1 
ATOM   654  C CA  . CYS A 1 109 ? 147.326 112.962 136.685 1.00 66.79  ? 180 CYS F CA  1 
ATOM   655  C C   . CYS A 1 109 ? 148.830 113.101 136.882 1.00 66.79  ? 180 CYS F C   1 
ATOM   656  O O   . CYS A 1 109 ? 149.604 112.878 135.944 1.00 66.79  ? 180 CYS F O   1 
ATOM   657  C CB  . CYS A 1 109 ? 146.951 111.522 136.332 1.00 66.79  ? 180 CYS F CB  1 
ATOM   658  S SG  . CYS A 1 109 ? 147.374 110.290 137.590 1.00 66.79  ? 180 CYS F SG  1 
ATOM   659  N N   . LYS A 1 110 ? 149.239 113.489 138.086 1.00 79.32  ? 181 LYS F N   1 
ATOM   660  C CA  . LYS A 1 110 ? 150.635 113.756 138.397 1.00 79.32  ? 181 LYS F CA  1 
ATOM   661  C C   . LYS A 1 110 ? 151.136 112.725 139.397 1.00 79.32  ? 181 LYS F C   1 
ATOM   662  O O   . LYS A 1 110 ? 150.535 112.543 140.461 1.00 79.32  ? 181 LYS F O   1 
ATOM   663  C CB  . LYS A 1 110 ? 150.803 115.170 138.958 1.00 79.32  ? 181 LYS F CB  1 
ATOM   664  C CG  . LYS A 1 110 ? 152.232 115.547 139.309 1.00 79.32  ? 181 LYS F CG  1 
ATOM   665  C CD  . LYS A 1 110 ? 152.301 116.973 139.834 1.00 79.32  ? 181 LYS F CD  1 
ATOM   666  C CE  . LYS A 1 110 ? 153.723 117.365 140.197 1.00 79.32  ? 181 LYS F CE  1 
ATOM   667  N NZ  . LYS A 1 110 ? 153.801 118.766 140.695 1.00 79.32  ? 181 LYS F NZ  1 
ATOM   668  N N   . VAL A 1 111 ? 152.232 112.053 139.054 1.00 88.30  ? 182 VAL F N   1 
ATOM   669  C CA  . VAL A 1 111 ? 152.846 111.051 139.915 1.00 88.30  ? 182 VAL F CA  1 
ATOM   670  C C   . VAL A 1 111 ? 154.221 111.553 140.330 1.00 88.30  ? 182 VAL F C   1 
ATOM   671  O O   . VAL A 1 111 ? 155.040 111.922 139.479 1.00 88.30  ? 182 VAL F O   1 
ATOM   672  C CB  . VAL A 1 111 ? 152.942 109.678 139.221 1.00 88.30  ? 182 VAL F CB  1 
ATOM   673  C CG1 . VAL A 1 111 ? 153.523 109.815 137.824 1.00 88.30  ? 182 VAL F CG1 1 
ATOM   674  C CG2 . VAL A 1 111 ? 153.779 108.721 140.054 1.00 88.30  ? 182 VAL F CG2 1 
ATOM   675  N N   . THR A 1 112 ? 154.465 111.583 141.635 1.00 94.34  ? 183 THR F N   1 
ATOM   676  C CA  . THR A 1 112 ? 155.756 111.961 142.193 1.00 94.34  ? 183 THR F CA  1 
ATOM   677  C C   . THR A 1 112 ? 156.410 110.717 142.776 1.00 94.34  ? 183 THR F C   1 
ATOM   678  O O   . THR A 1 112 ? 155.815 110.040 143.625 1.00 94.34  ? 183 THR F O   1 
ATOM   679  C CB  . THR A 1 112 ? 155.607 113.044 143.261 1.00 94.34  ? 183 THR F CB  1 
ATOM   680  O OG1 . THR A 1 112 ? 155.153 114.260 142.654 1.00 94.34  ? 183 THR F OG1 1 
ATOM   681  C CG2 . THR A 1 112 ? 156.936 113.292 143.961 1.00 94.34  ? 183 THR F CG2 1 
ATOM   682  N N   . SER A 1 113 ? 157.620 110.416 142.309 1.00 100.35 ? 184 SER F N   1 
ATOM   683  C CA  . SER A 1 113 ? 158.374 109.259 142.772 1.00 100.35 ? 184 SER F CA  1 
ATOM   684  C C   . SER A 1 113 ? 159.859 109.560 142.644 1.00 100.35 ? 184 SER F C   1 
ATOM   685  O O   . SER A 1 113 ? 160.309 110.016 141.588 1.00 100.35 ? 184 SER F O   1 
ATOM   686  C CB  . SER A 1 113 ? 158.012 108.004 141.971 1.00 100.35 ? 184 SER F CB  1 
ATOM   687  O OG  . SER A 1 113 ? 158.753 106.881 142.417 1.00 100.35 ? 184 SER F OG  1 
ATOM   688  N N   . GLN A 1 114 ? 160.609 109.306 143.720 1.00 102.98 ? 185 GLN F N   1 
ATOM   689  C CA  . GLN A 1 114 ? 162.049 109.570 143.772 1.00 102.98 ? 185 GLN F CA  1 
ATOM   690  C C   . GLN A 1 114 ? 162.370 111.032 143.476 1.00 102.98 ? 185 GLN F C   1 
ATOM   691  O O   . GLN A 1 114 ? 163.426 111.347 142.922 1.00 102.98 ? 185 GLN F O   1 
ATOM   692  C CB  . GLN A 1 114 ? 162.824 108.655 142.818 1.00 102.98 ? 185 GLN F CB  1 
ATOM   693  C CG  . GLN A 1 114 ? 162.877 107.198 143.243 1.00 102.98 ? 185 GLN F CG  1 
ATOM   694  C CD  . GLN A 1 114 ? 163.734 106.358 142.317 1.00 102.98 ? 185 GLN F CD  1 
ATOM   695  O OE1 . GLN A 1 114 ? 163.929 106.702 141.151 1.00 102.98 ? 185 GLN F OE1 1 
ATOM   696  N NE2 . GLN A 1 114 ? 164.258 105.253 142.834 1.00 102.98 ? 185 GLN F NE2 1 
ATOM   697  N N   . GLY A 1 115 ? 161.466 111.937 143.841 1.00 100.16 ? 186 GLY F N   1 
ATOM   698  C CA  . GLY A 1 115 ? 161.658 113.344 143.562 1.00 100.16 ? 186 GLY F CA  1 
ATOM   699  C C   . GLY A 1 115 ? 161.395 113.751 142.132 1.00 100.16 ? 186 GLY F C   1 
ATOM   700  O O   . GLY A 1 115 ? 161.637 114.912 141.780 1.00 100.16 ? 186 GLY F O   1 
ATOM   701  N N   . VAL A 1 116 ? 160.907 112.838 141.296 1.00 97.34  ? 187 VAL F N   1 
ATOM   702  C CA  . VAL A 1 116 ? 160.637 113.102 139.888 1.00 97.34  ? 187 VAL F CA  1 
ATOM   703  C C   . VAL A 1 116 ? 159.129 113.124 139.688 1.00 97.34  ? 187 VAL F C   1 
ATOM   704  O O   . VAL A 1 116 ? 158.419 112.234 140.174 1.00 97.34  ? 187 VAL F O   1 
ATOM   705  C CB  . VAL A 1 116 ? 161.300 112.052 138.980 1.00 97.34  ? 187 VAL F CB  1 
ATOM   706  C CG1 . VAL A 1 116 ? 161.087 112.404 137.516 1.00 97.34  ? 187 VAL F CG1 1 
ATOM   707  C CG2 . VAL A 1 116 ? 162.784 111.939 139.297 1.00 97.34  ? 187 VAL F CG2 1 
ATOM   708  N N   . ASP A 1 117 ? 158.643 114.141 138.982 1.00 92.62  ? 188 ASP F N   1 
ATOM   709  C CA  . ASP A 1 117 ? 157.221 114.329 138.733 1.00 92.62  ? 188 ASP F CA  1 
ATOM   710  C C   . ASP A 1 117 ? 156.916 114.053 137.267 1.00 92.62  ? 188 ASP F C   1 
ATOM   711  O O   . ASP A 1 117 ? 157.548 114.632 136.377 1.00 92.62  ? 188 ASP F O   1 
ATOM   712  C CB  . ASP A 1 117 ? 156.784 115.749 139.100 1.00 92.62  ? 188 ASP F CB  1 
ATOM   713  C CG  . ASP A 1 117 ? 157.149 116.122 140.523 1.00 92.62  ? 188 ASP F CG  1 
ATOM   714  O OD1 . ASP A 1 117 ? 157.274 115.208 141.364 1.00 92.62  ? 188 ASP F OD1 1 
ATOM   715  O OD2 . ASP A 1 117 ? 157.310 117.329 140.800 1.00 92.62  ? 188 ASP F OD2 1 
ATOM   716  N N   . TYR A 1 118 ? 155.949 113.172 137.023 1.00 83.94  ? 189 TYR F N   1 
ATOM   717  C CA  . TYR A 1 118 ? 155.475 112.862 135.682 1.00 83.94  ? 189 TYR F CA  1 
ATOM   718  C C   . TYR A 1 118 ? 153.996 113.208 135.588 1.00 83.94  ? 189 TYR F C   1 
ATOM   719  O O   . TYR A 1 118 ? 153.197 112.764 136.419 1.00 83.94  ? 189 TYR F O   1 
ATOM   720  C CB  . TYR A 1 118 ? 155.702 111.387 135.338 1.00 83.94  ? 189 TYR F CB  1 
ATOM   721  C CG  . TYR A 1 118 ? 157.153 111.030 135.103 1.00 83.94  ? 189 TYR F CG  1 
ATOM   722  C CD1 . TYR A 1 118 ? 158.059 111.982 134.655 1.00 83.94  ? 189 TYR F CD1 1 
ATOM   723  C CD2 . TYR A 1 118 ? 157.616 109.740 135.330 1.00 83.94  ? 189 TYR F CD2 1 
ATOM   724  C CE1 . TYR A 1 118 ? 159.385 111.660 134.438 1.00 83.94  ? 189 TYR F CE1 1 
ATOM   725  C CE2 . TYR A 1 118 ? 158.941 109.409 135.116 1.00 83.94  ? 189 TYR F CE2 1 
ATOM   726  C CZ  . TYR A 1 118 ? 159.821 110.373 134.670 1.00 83.94  ? 189 TYR F CZ  1 
ATOM   727  O OH  . TYR A 1 118 ? 161.141 110.048 134.456 1.00 83.94  ? 189 TYR F OH  1 
ATOM   728  N N   . LEU A 1 119 ? 153.636 113.995 134.578 1.00 79.72  ? 190 LEU F N   1 
ATOM   729  C CA  . LEU A 1 119 ? 152.277 114.493 134.411 1.00 79.72  ? 190 LEU F CA  1 
ATOM   730  C C   . LEU A 1 119 ? 151.691 113.949 133.117 1.00 79.72  ? 190 LEU F C   1 
ATOM   731  O O   . LEU A 1 119 ? 152.302 114.079 132.051 1.00 79.72  ? 190 LEU F O   1 
ATOM   732  C CB  . LEU A 1 119 ? 152.248 116.026 134.400 1.00 79.72  ? 190 LEU F CB  1 
ATOM   733  C CG  . LEU A 1 119 ? 152.484 116.783 135.713 1.00 79.72  ? 190 LEU F CG  1 
ATOM   734  C CD1 . LEU A 1 119 ? 153.948 116.759 136.134 1.00 79.72  ? 190 LEU F CD1 1 
ATOM   735  C CD2 . LEU A 1 119 ? 151.985 118.217 135.598 1.00 79.72  ? 190 LEU F CD2 1 
ATOM   736  N N   . ALA A 1 120 ? 150.509 113.343 133.211 1.00 65.29  ? 191 ALA F N   1 
ATOM   737  C CA  . ALA A 1 120 ? 149.773 112.855 132.051 1.00 65.29  ? 191 ALA F CA  1 
ATOM   738  C C   . ALA A 1 120 ? 148.496 113.670 131.909 1.00 65.29  ? 191 ALA F C   1 
ATOM   739  O O   . ALA A 1 120 ? 147.690 113.734 132.843 1.00 65.29  ? 191 ALA F O   1 
ATOM   740  C CB  . ALA A 1 120 ? 149.452 111.367 132.186 1.00 65.29  ? 191 ALA F CB  1 
ATOM   741  N N   . HIS A 1 121 ? 148.309 114.280 130.742 1.00 66.35  ? 192 HIS F N   1 
ATOM   742  C CA  . HIS A 1 121 ? 147.187 115.170 130.486 1.00 66.35  ? 192 HIS F CA  1 
ATOM   743  C C   . HIS A 1 121 ? 146.160 114.478 129.600 1.00 66.35  ? 192 HIS F C   1 
ATOM   744  O O   . HIS A 1 121 ? 146.515 113.833 128.608 1.00 66.35  ? 192 HIS F O   1 
ATOM   745  C CB  . HIS A 1 121 ? 147.661 116.467 129.824 1.00 66.35  ? 192 HIS F CB  1 
ATOM   746  C CG  . HIS A 1 121 ? 148.745 117.168 130.583 1.00 66.35  ? 192 HIS F CG  1 
ATOM   747  N ND1 . HIS A 1 121 ? 148.501 118.243 131.410 1.00 66.35  ? 192 HIS F ND1 1 
ATOM   748  C CD2 . HIS A 1 121 ? 150.079 116.944 130.643 1.00 66.35  ? 192 HIS F CD2 1 
ATOM   749  C CE1 . HIS A 1 121 ? 149.637 118.653 131.944 1.00 66.35  ? 192 HIS F CE1 1 
ATOM   750  N NE2 . HIS A 1 121 ? 150.610 117.880 131.496 1.00 66.35  ? 192 HIS F NE2 1 
ATOM   751  N N   . THR A 1 122 ? 144.886 114.616 129.964 1.00 59.68  ? 193 THR F N   1 
ATOM   752  C CA  . THR A 1 122 ? 143.797 113.996 129.228 1.00 59.68  ? 193 THR F CA  1 
ATOM   753  C C   . THR A 1 122 ? 142.664 114.996 129.054 1.00 59.68  ? 193 THR F C   1 
ATOM   754  O O   . THR A 1 122 ? 142.549 115.986 129.788 1.00 59.68  ? 193 THR F O   1 
ATOM   755  C CB  . THR A 1 122 ? 143.271 112.735 129.929 1.00 59.68  ? 193 THR F CB  1 
ATOM   756  O OG1 . THR A 1 122 ? 142.559 111.926 128.985 1.00 59.68  ? 193 THR F OG1 1 
ATOM   757  C CG2 . THR A 1 122 ? 142.327 113.109 131.063 1.00 59.68  ? 193 THR F CG2 1 
ATOM   758  N N   . ARG A 1 123 ? 141.827 114.717 128.059 1.00 60.24  ? 194 ARG F N   1 
ATOM   759  C CA  . ARG A 1 123 ? 140.647 115.505 127.728 1.00 60.24  ? 194 ARG F CA  1 
ATOM   760  C C   . ARG A 1 123 ? 139.844 114.703 126.713 1.00 60.24  ? 194 ARG F C   1 
ATOM   761  O O   . ARG A 1 123 ? 140.254 113.620 126.284 1.00 60.24  ? 194 ARG F O   1 
ATOM   762  C CB  . ARG A 1 123 ? 141.004 116.880 127.167 1.00 60.24  ? 194 ARG F CB  1 
ATOM   763  C CG  . ARG A 1 123 ? 141.785 116.836 125.864 1.00 60.24  ? 194 ARG F CG  1 
ATOM   764  C CD  . ARG A 1 123 ? 142.101 118.236 125.366 1.00 60.24  ? 194 ARG F CD  1 
ATOM   765  N NE  . ARG A 1 123 ? 142.807 118.215 124.090 1.00 60.24  ? 194 ARG F NE  1 
ATOM   766  C CZ  . ARG A 1 123 ? 142.212 118.229 122.905 1.00 60.24  ? 194 ARG F CZ  1 
ATOM   767  N NH1 . ARG A 1 123 ? 140.894 118.262 122.794 1.00 60.24  ? 194 ARG F NH1 1 
ATOM   768  N NH2 . ARG A 1 123 ? 142.958 118.210 121.804 1.00 60.24  ? 194 ARG F NH2 1 
ATOM   769  N N   . ARG A 1 124 ? 138.692 115.247 126.334 1.00 59.36  ? 195 ARG F N   1 
ATOM   770  C CA  . ARG A 1 124 ? 137.894 114.630 125.288 1.00 59.36  ? 195 ARG F CA  1 
ATOM   771  C C   . ARG A 1 124 ? 138.597 114.758 123.940 1.00 59.36  ? 195 ARG F C   1 
ATOM   772  O O   . ARG A 1 124 ? 139.409 115.659 123.714 1.00 59.36  ? 195 ARG F O   1 
ATOM   773  C CB  . ARG A 1 124 ? 136.514 115.278 125.207 1.00 59.36  ? 195 ARG F CB  1 
ATOM   774  C CG  . ARG A 1 124 ? 135.622 115.028 126.403 1.00 59.36  ? 195 ARG F CG  1 
ATOM   775  C CD  . ARG A 1 124 ? 134.269 115.660 126.167 1.00 59.36  ? 195 ARG F CD  1 
ATOM   776  N NE  . ARG A 1 124 ? 133.735 115.280 124.864 1.00 59.36  ? 195 ARG F NE  1 
ATOM   777  C CZ  . ARG A 1 124 ? 132.896 116.021 124.156 1.00 59.36  ? 195 ARG F CZ  1 
ATOM   778  N NH1 . ARG A 1 124 ? 132.479 117.199 124.591 1.00 59.36  ? 195 ARG F NH1 1 
ATOM   779  N NH2 . ARG A 1 124 ? 132.471 115.574 122.978 1.00 59.36  ? 195 ARG F NH2 1 
ATOM   780  N N   . CYS A 1 125 ? 138.278 113.835 123.040 1.00 67.98  ? 196 CYS F N   1 
ATOM   781  C CA  . CYS A 1 125 ? 138.765 113.955 121.676 1.00 67.98  ? 196 CYS F CA  1 
ATOM   782  C C   . CYS A 1 125 ? 138.128 115.177 121.018 1.00 67.98  ? 196 CYS F C   1 
ATOM   783  O O   . CYS A 1 125 ? 136.939 115.442 121.224 1.00 67.98  ? 196 CYS F O   1 
ATOM   784  C CB  . CYS A 1 125 ? 138.467 112.686 120.881 1.00 67.98  ? 196 CYS F CB  1 
ATOM   785  S SG  . CYS A 1 125 ? 139.258 111.253 121.629 1.00 67.98  ? 196 CYS F SG  1 
ATOM   786  N N   . PRO A 1 126 ? 138.893 115.941 120.239 1.00 63.36  ? 197 PRO F N   1 
ATOM   787  C CA  . PRO A 1 126 ? 138.461 117.296 119.873 1.00 63.36  ? 197 PRO F CA  1 
ATOM   788  C C   . PRO A 1 126 ? 137.120 117.321 119.153 1.00 63.36  ? 197 PRO F C   1 
ATOM   789  O O   . PRO A 1 126 ? 136.857 116.528 118.246 1.00 63.36  ? 197 PRO F O   1 
ATOM   790  C CB  . PRO A 1 126 ? 139.591 117.791 118.963 1.00 63.36  ? 197 PRO F CB  1 
ATOM   791  C CG  . PRO A 1 126 ? 140.780 116.983 119.366 1.00 63.36  ? 197 PRO F CG  1 
ATOM   792  C CD  . PRO A 1 126 ? 140.239 115.632 119.727 1.00 63.36  ? 197 PRO F CD  1 
ATOM   793  N N   . ASP A 1 127 ? 136.273 118.252 119.578 1.00 56.10  ? 198 ASP F N   1 
ATOM   794  C CA  . ASP A 1 127 ? 135.039 118.614 118.902 1.00 56.10  ? 198 ASP F CA  1 
ATOM   795  C C   . ASP A 1 127 ? 135.047 120.118 118.663 1.00 56.10  ? 198 ASP F C   1 
ATOM   796  O O   . ASP A 1 127 ? 135.825 120.858 119.272 1.00 56.10  ? 198 ASP F O   1 
ATOM   797  C CB  . ASP A 1 127 ? 133.807 118.196 119.715 1.00 56.10  ? 198 ASP F CB  1 
ATOM   798  C CG  . ASP A 1 127 ? 133.504 116.715 119.595 1.00 56.10  ? 198 ASP F CG  1 
ATOM   799  O OD1 . ASP A 1 127 ? 133.809 116.129 118.535 1.00 56.10  ? 198 ASP F OD1 1 
ATOM   800  O OD2 . ASP A 1 127 ? 132.957 116.137 120.558 1.00 56.10  ? 198 ASP F OD2 1 
ATOM   801  N N   . HIS A 1 128 ? 134.183 120.560 117.746 1.00 50.13  ? 199 HIS F N   1 
ATOM   802  C CA  . HIS A 1 128 ? 134.146 121.951 117.303 1.00 50.13  ? 199 HIS F CA  1 
ATOM   803  C C   . HIS A 1 128 ? 135.469 122.323 116.643 1.00 50.13  ? 199 HIS F C   1 
ATOM   804  O O   . HIS A 1 128 ? 136.313 121.455 116.396 1.00 50.13  ? 199 HIS F O   1 
ATOM   805  C CB  . HIS A 1 128 ? 133.841 122.904 118.466 1.00 50.13  ? 199 HIS F CB  1 
ATOM   806  C CG  . HIS A 1 128 ? 132.574 122.586 119.198 1.00 50.13  ? 199 HIS F CG  1 
ATOM   807  N ND1 . HIS A 1 128 ? 132.292 123.093 120.449 1.00 50.13  ? 199 HIS F ND1 1 
ATOM   808  C CD2 . HIS A 1 128 ? 131.512 121.819 118.855 1.00 50.13  ? 199 HIS F CD2 1 
ATOM   809  C CE1 . HIS A 1 128 ? 131.113 122.649 120.846 1.00 50.13  ? 199 HIS F CE1 1 
ATOM   810  N NE2 . HIS A 1 128 ? 130.618 121.874 119.897 1.00 50.13  ? 199 HIS F NE2 1 
ATOM   811  N N   . GLU A 1 129 ? 135.653 123.597 116.338 1.00 42.02  ? 200 GLU F N   1 
ATOM   812  C CA  . GLU A 1 129 ? 136.941 123.942 115.758 1.00 42.02  ? 200 GLU F CA  1 
ATOM   813  C C   . GLU A 1 129 ? 137.956 124.263 116.852 1.00 42.02  ? 200 GLU F C   1 
ATOM   814  O O   . GLU A 1 129 ? 137.581 124.657 117.960 1.00 42.02  ? 200 GLU F O   1 
ATOM   815  C CB  . GLU A 1 129 ? 136.798 125.139 114.821 1.00 42.02  ? 200 GLU F CB  1 
ATOM   816  C CG  . GLU A 1 129 ? 135.934 124.865 113.602 1.00 42.02  ? 200 GLU F CG  1 
ATOM   817  C CD  . GLU A 1 129 ? 136.512 123.787 112.705 1.00 42.02  ? 200 GLU F CD  1 
ATOM   818  O OE1 . GLU A 1 129 ? 137.753 123.652 112.654 1.00 42.02  ? 200 GLU F OE1 1 
ATOM   819  O OE2 . GLU A 1 129 ? 135.724 123.070 112.052 1.00 42.02  ? 200 GLU F OE2 1 
ATOM   820  N N   . PRO A 1 130 ? 139.248 124.082 116.572 1.00 36.78  ? 201 PRO F N   1 
ATOM   821  C CA  . PRO A 1 130 ? 140.271 124.463 117.553 1.00 36.78  ? 201 PRO F CA  1 
ATOM   822  C C   . PRO A 1 130 ? 140.231 125.955 117.847 1.00 36.78  ? 201 PRO F C   1 
ATOM   823  O O   . PRO A 1 130 ? 139.916 126.775 116.983 1.00 36.78  ? 201 PRO F O   1 
ATOM   824  C CB  . PRO A 1 130 ? 141.584 124.061 116.872 1.00 36.78  ? 201 PRO F CB  1 
ATOM   825  C CG  . PRO A 1 130 ? 141.194 122.995 115.903 1.00 36.78  ? 201 PRO F CG  1 
ATOM   826  C CD  . PRO A 1 130 ? 139.826 123.376 115.417 1.00 36.78  ? 201 PRO F CD  1 
ATOM   827  N N   . ARG A 1 131 ? 140.550 126.301 119.091 1.00 33.30  ? 202 ARG F N   1 
ATOM   828  C CA  . ARG A 1 131 ? 140.524 127.695 119.508 1.00 33.30  ? 202 ARG F CA  1 
ATOM   829  C C   . ARG A 1 131 ? 141.672 128.470 118.869 1.00 33.30  ? 202 ARG F C   1 
ATOM   830  O O   . ARG A 1 131 ? 142.783 127.959 118.703 1.00 33.30  ? 202 ARG F O   1 
ATOM   831  C CB  . ARG A 1 131 ? 140.600 127.797 121.031 1.00 33.30  ? 202 ARG F CB  1 
ATOM   832  C CG  . ARG A 1 131 ? 140.199 129.154 121.586 1.00 33.30  ? 202 ARG F CG  1 
ATOM   833  C CD  . ARG A 1 131 ? 140.162 129.136 123.105 1.00 33.30  ? 202 ARG F CD  1 
ATOM   834  N NE  . ARG A 1 131 ? 139.314 128.067 123.617 1.00 33.30  ? 202 ARG F NE  1 
ATOM   835  C CZ  . ARG A 1 131 ? 138.013 128.185 123.844 1.00 33.30  ? 202 ARG F CZ  1 
ATOM   836  N NH1 . ARG A 1 131 ? 137.372 129.319 123.613 1.00 33.30  ? 202 ARG F NH1 1 
ATOM   837  N NH2 . ARG A 1 131 ? 137.339 127.140 124.315 1.00 33.30  ? 202 ARG F NH2 1 
ATOM   838  N N   . GLY A 1 132 ? 141.391 129.719 118.510 1.00 28.31  ? 203 GLY F N   1 
ATOM   839  C CA  . GLY A 1 132 ? 142.360 130.589 117.865 1.00 28.31  ? 203 GLY F CA  1 
ATOM   840  C C   . GLY A 1 132 ? 143.210 131.309 118.899 1.00 28.31  ? 203 GLY F C   1 
ATOM   841  O O   . GLY A 1 132 ? 142.931 131.248 120.098 1.00 28.31  ? 203 GLY F O   1 
ATOM   842  N N   . VAL A 1 133 ? 144.252 131.982 118.413 1.00 26.54  ? 204 VAL F N   1 
ATOM   843  C CA  . VAL A 1 133 ? 145.157 132.744 119.267 1.00 26.54  ? 204 VAL F CA  1 
ATOM   844  C C   . VAL A 1 133 ? 144.382 133.868 119.940 1.00 26.54  ? 204 VAL F C   1 
ATOM   845  O O   . VAL A 1 133 ? 143.671 134.630 119.276 1.00 26.54  ? 204 VAL F O   1 
ATOM   846  C CB  . VAL A 1 133 ? 146.346 133.300 118.463 1.00 26.54  ? 204 VAL F CB  1 
ATOM   847  C CG1 . VAL A 1 133 ? 147.366 133.941 119.394 1.00 26.54  ? 204 VAL F CG1 1 
ATOM   848  C CG2 . VAL A 1 133 ? 146.985 132.201 117.628 1.00 26.54  ? 204 VAL F CG2 1 
ATOM   849  N N   . ILE A 1 134 ? 144.513 133.982 121.260 1.00 25.98  ? 205 ILE F N   1 
ATOM   850  C CA  . ILE A 1 134 ? 143.791 134.983 122.037 1.00 25.98  ? 205 ILE F CA  1 
ATOM   851  C C   . ILE A 1 134 ? 144.786 135.765 122.884 1.00 25.98  ? 205 ILE F C   1 
ATOM   852  O O   . ILE A 1 134 ? 145.684 135.185 123.506 1.00 25.98  ? 205 ILE F O   1 
ATOM   853  C CB  . ILE A 1 134 ? 142.690 134.338 122.908 1.00 25.98  ? 205 ILE F CB  1 
ATOM   854  C CG1 . ILE A 1 134 ? 142.108 135.352 123.897 1.00 25.98  ? 205 ILE F CG1 1 
ATOM   855  C CG2 . ILE A 1 134 ? 143.212 133.099 123.615 1.00 25.98  ? 205 ILE F CG2 1 
ATOM   856  C CD1 . ILE A 1 134 ? 141.338 136.477 123.239 1.00 25.98  ? 205 ILE F CD1 1 
ATOM   857  N N   . THR A 1 135 ? 144.626 137.087 122.895 1.00 24.80  ? 206 THR F N   1 
ATOM   858  C CA  . THR A 1 135 ? 145.532 137.997 123.581 1.00 24.80  ? 206 THR F CA  1 
ATOM   859  C C   . THR A 1 135 ? 144.919 138.467 124.895 1.00 24.80  ? 206 THR F C   1 
ATOM   860  O O   . THR A 1 135 ? 143.723 138.764 124.965 1.00 24.80  ? 206 THR F O   1 
ATOM   861  C CB  . THR A 1 135 ? 145.852 139.209 122.700 1.00 24.80  ? 206 THR F CB  1 
ATOM   862  O OG1 . THR A 1 135 ? 146.234 138.764 121.393 1.00 24.80  ? 206 THR F OG1 1 
ATOM   863  C CG2 . THR A 1 135 ? 146.986 140.028 123.302 1.00 24.80  ? 206 THR F CG2 1 
ATOM   864  N N   . TYR A 1 136 ? 145.751 138.534 125.933 1.00 25.27  ? 207 TYR F N   1 
ATOM   865  C CA  . TYR A 1 136 ? 145.357 138.996 127.255 1.00 25.27  ? 207 TYR F CA  1 
ATOM   866  C C   . TYR A 1 136 ? 146.309 140.094 127.704 1.00 25.27  ? 207 TYR F C   1 
ATOM   867  O O   . TYR A 1 136 ? 147.521 140.011 127.475 1.00 25.27  ? 207 TYR F O   1 
ATOM   868  C CB  . TYR A 1 136 ? 145.361 137.847 128.269 1.00 25.27  ? 207 TYR F CB  1 
ATOM   869  C CG  . TYR A 1 136 ? 144.320 136.786 127.997 1.00 25.27  ? 207 TYR F CG  1 
ATOM   870  C CD1 . TYR A 1 136 ? 143.047 137.130 127.562 1.00 25.27  ? 207 TYR F CD1 1 
ATOM   871  C CD2 . TYR A 1 136 ? 144.609 135.439 128.174 1.00 25.27  ? 207 TYR F CD2 1 
ATOM   872  C CE1 . TYR A 1 136 ? 142.090 136.165 127.315 1.00 25.27  ? 207 TYR F CE1 1 
ATOM   873  C CE2 . TYR A 1 136 ? 143.660 134.466 127.928 1.00 25.27  ? 207 TYR F CE2 1 
ATOM   874  C CZ  . TYR A 1 136 ? 142.403 134.834 127.498 1.00 25.27  ? 207 TYR F CZ  1 
ATOM   875  O OH  . TYR A 1 136 ? 141.454 133.869 127.251 1.00 25.27  ? 207 TYR F OH  1 
ATOM   876  N N   . LEU A 1 137 ? 145.753 141.120 128.342 1.00 22.55  ? 208 LEU F N   1 
ATOM   877  C CA  . LEU A 1 137 ? 146.506 142.294 128.765 1.00 22.55  ? 208 LEU F CA  1 
ATOM   878  C C   . LEU A 1 137 ? 146.352 142.461 130.270 1.00 22.55  ? 208 LEU F C   1 
ATOM   879  O O   . LEU A 1 137 ? 145.231 142.604 130.770 1.00 22.55  ? 208 LEU F O   1 
ATOM   880  C CB  . LEU A 1 137 ? 146.021 143.540 128.022 1.00 22.55  ? 208 LEU F CB  1 
ATOM   881  C CG  . LEU A 1 137 ? 146.949 144.750 127.943 1.00 22.55  ? 208 LEU F CG  1 
ATOM   882  C CD1 . LEU A 1 137 ? 148.345 144.330 127.526 1.00 22.55  ? 208 LEU F CD1 1 
ATOM   883  C CD2 . LEU A 1 137 ? 146.382 145.750 126.954 1.00 22.55  ? 208 LEU F CD2 1 
ATOM   884  N N   . ILE A 1 138 ? 147.472 142.441 130.983 1.00 21.24  ? 209 ILE F N   1 
ATOM   885  C CA  . ILE A 1 138 ? 147.517 142.550 132.436 1.00 21.24  ? 209 ILE F CA  1 
ATOM   886  C C   . ILE A 1 138 ? 148.103 143.917 132.785 1.00 21.24  ? 209 ILE F C   1 
ATOM   887  O O   . ILE A 1 138 ? 149.283 144.179 132.496 1.00 21.24  ? 209 ILE F O   1 
ATOM   888  C CB  . ILE A 1 138 ? 148.336 141.416 133.066 1.00 21.24  ? 209 ILE F CB  1 
ATOM   889  C CG1 . ILE A 1 138 ? 147.727 140.058 132.712 1.00 21.24  ? 209 ILE F CG1 1 
ATOM   890  C CG2 . ILE A 1 138 ? 148.416 141.592 134.575 1.00 21.24  ? 209 ILE F CG2 1 
ATOM   891  C CD1 . ILE A 1 138 ? 148.482 138.881 133.288 1.00 21.24  ? 209 ILE F CD1 1 
ATOM   892  N N   . PRO A 1 139 ? 147.325 144.815 133.384 1.00 19.17  ? 210 PRO F N   1 
ATOM   893  C CA  . PRO A 1 139 ? 147.862 146.107 133.816 1.00 19.17  ? 210 PRO F CA  1 
ATOM   894  C C   . PRO A 1 139 ? 148.720 145.949 135.058 1.00 19.17  ? 210 PRO F C   1 
ATOM   895  O O   . PRO A 1 139 ? 148.622 144.933 135.763 1.00 19.17  ? 210 PRO F O   1 
ATOM   896  C CB  . PRO A 1 139 ? 146.598 146.929 134.109 1.00 19.17  ? 210 PRO F CB  1 
ATOM   897  C CG  . PRO A 1 139 ? 145.585 145.908 134.497 1.00 19.17  ? 210 PRO F CG  1 
ATOM   898  C CD  . PRO A 1 139 ? 145.882 144.693 133.658 1.00 19.17  ? 210 PRO F CD  1 
ATOM   899  N N   . PRO A 1 140 ? 149.580 146.923 135.354 1.00 19.07  ? 211 PRO F N   1 
ATOM   900  C CA  . PRO A 1 140 ? 150.426 146.818 136.549 1.00 19.07  ? 211 PRO F CA  1 
ATOM   901  C C   . PRO A 1 140 ? 149.599 146.787 137.826 1.00 19.07  ? 211 PRO F C   1 
ATOM   902  O O   . PRO A 1 140 ? 148.561 147.444 137.934 1.00 19.07  ? 211 PRO F O   1 
ATOM   903  C CB  . PRO A 1 140 ? 151.298 148.077 136.479 1.00 19.07  ? 211 PRO F CB  1 
ATOM   904  C CG  . PRO A 1 140 ? 151.239 148.516 135.052 1.00 19.07  ? 211 PRO F CG  1 
ATOM   905  C CD  . PRO A 1 140 ? 149.875 148.137 134.575 1.00 19.07  ? 211 PRO F CD  1 
ATOM   906  N N   . SER A 1 141 ? 150.072 146.011 138.797 1.00 18.43  ? 212 SER F N   1 
ATOM   907  C CA  . SER A 1 141 ? 149.432 145.962 140.100 1.00 18.43  ? 212 SER F CA  1 
ATOM   908  C C   . SER A 1 141 ? 149.763 147.219 140.904 1.00 18.43  ? 212 SER F C   1 
ATOM   909  O O   . SER A 1 141 ? 150.852 147.783 140.766 1.00 18.43  ? 212 SER F O   1 
ATOM   910  C CB  . SER A 1 141 ? 149.882 144.724 140.869 1.00 18.43  ? 212 SER F CB  1 
ATOM   911  O OG  . SER A 1 141 ? 151.285 144.728 141.066 1.00 18.43  ? 212 SER F OG  1 
ATOM   912  N N   . PRO A 1 142 ? 148.833 147.682 141.743 1.00 15.82  ? 213 PRO F N   1 
ATOM   913  C CA  . PRO A 1 142 ? 149.125 148.861 142.575 1.00 15.82  ? 213 PRO F CA  1 
ATOM   914  C C   . PRO A 1 142 ? 150.289 148.657 143.528 1.00 15.82  ? 213 PRO F C   1 
ATOM   915  O O   . PRO A 1 142 ? 150.950 149.635 143.900 1.00 15.82  ? 213 PRO F O   1 
ATOM   916  C CB  . PRO A 1 142 ? 147.808 149.090 143.331 1.00 15.82  ? 213 PRO F CB  1 
ATOM   917  C CG  . PRO A 1 142 ? 146.764 148.419 142.496 1.00 15.82  ? 213 PRO F CG  1 
ATOM   918  C CD  . PRO A 1 142 ? 147.441 147.226 141.895 1.00 15.82  ? 213 PRO F CD  1 
ATOM   919  N N   . LEU A 1 143 ? 150.558 147.414 143.938 1.00 17.95  ? 214 LEU F N   1 
ATOM   920  C CA  . LEU A 1 143 ? 151.661 147.155 144.858 1.00 17.95  ? 214 LEU F CA  1 
ATOM   921  C C   . LEU A 1 143 ? 152.999 147.537 144.237 1.00 17.95  ? 214 LEU F C   1 
ATOM   922  O O   . LEU A 1 143 ? 153.845 148.154 144.895 1.00 17.95  ? 214 LEU F O   1 
ATOM   923  C CB  . LEU A 1 143 ? 151.655 145.682 145.274 1.00 17.95  ? 214 LEU F CB  1 
ATOM   924  C CG  . LEU A 1 143 ? 152.517 145.232 146.458 1.00 17.95  ? 214 LEU F CG  1 
ATOM   925  C CD1 . LEU A 1 143 ? 151.881 144.024 147.124 1.00 17.95  ? 214 LEU F CD1 1 
ATOM   926  C CD2 . LEU A 1 143 ? 153.940 144.902 146.029 1.00 17.95  ? 214 LEU F CD2 1 
ATOM   927  N N   . ASP A 1 144 ? 153.210 147.180 142.971 1.00 20.32  ? 215 ASP F N   1 
ATOM   928  C CA  . ASP A 1 144 ? 154.432 147.552 142.270 1.00 20.32  ? 215 ASP F CA  1 
ATOM   929  C C   . ASP A 1 144 ? 154.366 148.952 141.675 1.00 20.32  ? 215 ASP F C   1 
ATOM   930  O O   . ASP A 1 144 ? 155.377 149.434 141.153 1.00 20.32  ? 215 ASP F O   1 
ATOM   931  C CB  . ASP A 1 144 ? 154.733 146.540 141.162 1.00 20.32  ? 215 ASP F CB  1 
ATOM   932  C CG  . ASP A 1 144 ? 154.908 145.131 141.693 1.00 20.32  ? 215 ASP F CG  1 
ATOM   933  O OD1 . ASP A 1 144 ? 155.361 144.980 142.847 1.00 20.32  ? 215 ASP F OD1 1 
ATOM   934  O OD2 . ASP A 1 144 ? 154.594 144.173 140.955 1.00 20.32  ? 215 ASP F OD2 1 
ATOM   935  N N   . LEU A 1 145 ? 153.211 149.611 141.745 1.00 17.92  ? 216 LEU F N   1 
ATOM   936  C CA  . LEU A 1 145 ? 153.023 150.927 141.150 1.00 17.92  ? 216 LEU F CA  1 
ATOM   937  C C   . LEU A 1 145 ? 153.153 152.067 142.150 1.00 17.92  ? 216 LEU F C   1 
ATOM   938  O O   . LEU A 1 145 ? 153.628 153.146 141.781 1.00 17.92  ? 216 LEU F O   1 
ATOM   939  C CB  . LEU A 1 145 ? 151.650 151.000 140.472 1.00 17.92  ? 216 LEU F CB  1 
ATOM   940  C CG  . LEU A 1 145 ? 151.215 152.308 139.810 1.00 17.92  ? 216 LEU F CG  1 
ATOM   941  C CD1 . LEU A 1 145 ? 152.247 152.780 138.803 1.00 17.92  ? 216 LEU F CD1 1 
ATOM   942  C CD2 . LEU A 1 145 ? 149.865 152.122 139.141 1.00 17.92  ? 216 LEU F CD2 1 
ATOM   943  N N   . TYR A 1 146 ? 152.756 151.857 143.406 1.00 18.49  ? 217 TYR F N   1 
ATOM   944  C CA  . TYR A 1 146 ? 152.788 152.914 144.406 1.00 18.49  ? 217 TYR F CA  1 
ATOM   945  C C   . TYR A 1 146 ? 153.665 152.606 145.610 1.00 18.49  ? 217 TYR F C   1 
ATOM   946  O O   . TYR A 1 146 ? 153.857 153.494 146.450 1.00 18.49  ? 217 TYR F O   1 
ATOM   947  C CB  . TYR A 1 146 ? 151.364 153.231 144.892 1.00 18.49  ? 217 TYR F CB  1 
ATOM   948  C CG  . TYR A 1 146 ? 150.407 153.556 143.768 1.00 18.49  ? 217 TYR F CG  1 
ATOM   949  C CD1 . TYR A 1 146 ? 150.458 154.783 143.120 1.00 18.49  ? 217 TYR F CD1 1 
ATOM   950  C CD2 . TYR A 1 146 ? 149.455 152.635 143.353 1.00 18.49  ? 217 TYR F CD2 1 
ATOM   951  C CE1 . TYR A 1 146 ? 149.587 155.084 142.090 1.00 18.49  ? 217 TYR F CE1 1 
ATOM   952  C CE2 . TYR A 1 146 ? 148.579 152.926 142.325 1.00 18.49  ? 217 TYR F CE2 1 
ATOM   953  C CZ  . TYR A 1 146 ? 148.650 154.152 141.697 1.00 18.49  ? 217 TYR F CZ  1 
ATOM   954  O OH  . TYR A 1 146 ? 147.782 154.446 140.671 1.00 18.49  ? 217 TYR F OH  1 
ATOM   955  N N   . GLN A 1 147 ? 154.201 151.392 145.726 1.00 22.44  ? 218 GLN F N   1 
ATOM   956  C CA  . GLN A 1 147 ? 155.094 151.036 146.822 1.00 22.44  ? 218 GLN F CA  1 
ATOM   957  C C   . GLN A 1 147 ? 156.508 150.749 146.333 1.00 22.44  ? 218 GLN F C   1 
ATOM   958  O O   . GLN A 1 147 ? 157.464 151.372 146.802 1.00 22.44  ? 218 GLN F O   1 
ATOM   959  C CB  . GLN A 1 147 ? 154.536 149.829 147.589 1.00 22.44  ? 218 GLN F CB  1 
ATOM   960  C CG  . GLN A 1 147 ? 153.227 150.104 148.310 1.00 22.44  ? 218 GLN F CG  1 
ATOM   961  C CD  . GLN A 1 147 ? 153.382 151.088 149.454 1.00 22.44  ? 218 GLN F CD  1 
ATOM   962  O OE1 . GLN A 1 147 ? 152.462 151.844 149.767 1.00 22.44  ? 218 GLN F OE1 1 
ATOM   963  N NE2 . GLN A 1 147 ? 154.548 151.078 150.091 1.00 22.44  ? 218 GLN F NE2 1 
ATOM   964  N N   . ASN A 1 148 ? 156.668 149.815 145.396 1.00 24.31  ? 219 ASN F N   1 
ATOM   965  C CA  . ASN A 1 148 ? 157.979 149.514 144.839 1.00 24.31  ? 219 ASN F CA  1 
ATOM   966  C C   . ASN A 1 148 ? 158.352 150.420 143.675 1.00 24.31  ? 219 ASN F C   1 
ATOM   967  O O   . ASN A 1 148 ? 159.534 150.492 143.319 1.00 24.31  ? 219 ASN F O   1 
ATOM   968  C CB  . ASN A 1 148 ? 158.038 148.052 144.383 1.00 24.31  ? 219 ASN F CB  1 
ATOM   969  C CG  . ASN A 1 148 ? 157.814 147.077 145.521 1.00 24.31  ? 219 ASN F CG  1 
ATOM   970  O OD1 . ASN A 1 148 ? 158.147 147.361 146.672 1.00 24.31  ? 219 ASN F OD1 1 
ATOM   971  N ND2 . ASN A 1 148 ? 157.247 145.918 145.205 1.00 24.31  ? 219 ASN F ND2 1 
ATOM   972  N N   . GLY A 1 149 ? 157.381 151.111 143.084 1.00 24.33  ? 220 GLY F N   1 
ATOM   973  C CA  . GLY A 1 149 ? 157.660 152.014 141.981 1.00 24.33  ? 220 GLY F CA  1 
ATOM   974  C C   . GLY A 1 149 ? 158.209 151.340 140.745 1.00 24.33  ? 220 GLY F C   1 
ATOM   975  O O   . GLY A 1 149 ? 159.012 151.942 140.024 1.00 24.33  ? 220 GLY F O   1 
ATOM   976  N N   . ALA A 1 150 ? 157.797 150.103 140.475 1.00 21.10  ? 221 ALA F N   1 
ATOM   977  C CA  . ALA A 1 150 ? 158.222 149.365 139.286 1.00 21.10  ? 221 ALA F CA  1 
ATOM   978  C C   . ALA A 1 150 ? 157.009 148.724 138.622 1.00 21.10  ? 221 ALA F C   1 
ATOM   979  O O   . ALA A 1 150 ? 156.855 147.497 138.629 1.00 21.10  ? 221 ALA F O   1 
ATOM   980  C CB  . ALA A 1 150 ? 159.272 148.312 139.641 1.00 21.10  ? 221 ALA F CB  1 
ATOM   981  N N   . PRO A 1 151 ? 156.121 149.529 138.039 1.00 20.10  ? 222 PRO F N   1 
ATOM   982  C CA  . PRO A 1 151 ? 154.966 148.958 137.340 1.00 20.10  ? 222 PRO F CA  1 
ATOM   983  C C   . PRO A 1 151 ? 155.385 148.244 136.065 1.00 20.10  ? 222 PRO F C   1 
ATOM   984  O O   . PRO A 1 151 ? 156.398 148.573 135.443 1.00 20.10  ? 222 PRO F O   1 
ATOM   985  C CB  . PRO A 1 151 ? 154.096 150.181 137.035 1.00 20.10  ? 222 PRO F CB  1 
ATOM   986  C CG  . PRO A 1 151 ? 155.058 151.306 136.957 1.00 20.10  ? 222 PRO F CG  1 
ATOM   987  C CD  . PRO A 1 151 ? 156.151 151.000 137.944 1.00 20.10  ? 222 PRO F CD  1 
ATOM   988  N N   . LYS A 1 152 ? 154.586 147.251 135.677 1.00 18.28  ? 223 LYS F N   1 
ATOM   989  C CA  . LYS A 1 152 ? 154.861 146.471 134.480 1.00 18.28  ? 223 LYS F CA  1 
ATOM   990  C C   . LYS A 1 152 ? 153.557 146.087 133.796 1.00 18.28  ? 223 LYS F C   1 
ATOM   991  O O   . LYS A 1 152 ? 152.599 145.669 134.451 1.00 18.28  ? 223 LYS F O   1 
ATOM   992  C CB  . LYS A 1 152 ? 155.676 145.210 134.808 1.00 18.28  ? 223 LYS F CB  1 
ATOM   993  C CG  . LYS A 1 152 ? 155.075 144.337 135.899 1.00 18.28  ? 223 LYS F CG  1 
ATOM   994  C CD  . LYS A 1 152 ? 155.903 143.082 136.120 1.00 18.28  ? 223 LYS F CD  1 
ATOM   995  C CE  . LYS A 1 152 ? 157.326 143.423 136.533 1.00 18.28  ? 223 LYS F CE  1 
ATOM   996  N NZ  . LYS A 1 152 ? 157.364 144.199 137.803 1.00 18.28  ? 223 LYS F NZ  1 
ATOM   997  N N   . LEU A 1 153 ? 153.536 146.228 132.474 1.00 21.21  ? 224 LEU F N   1 
ATOM   998  C CA  . LEU A 1 153 ? 152.401 145.831 131.651 1.00 21.21  ? 224 LEU F CA  1 
ATOM   999  C C   . LEU A 1 153 ? 152.716 144.505 130.973 1.00 21.21  ? 224 LEU F C   1 
ATOM   1000 O O   . LEU A 1 153 ? 153.788 144.349 130.380 1.00 21.21  ? 224 LEU F O   1 
ATOM   1001 C CB  . LEU A 1 153 ? 152.086 146.898 130.602 1.00 21.21  ? 224 LEU F CB  1 
ATOM   1002 C CG  . LEU A 1 153 ? 151.128 148.019 131.006 1.00 21.21  ? 224 LEU F CG  1 
ATOM   1003 C CD1 . LEU A 1 153 ? 151.263 149.196 130.061 1.00 21.21  ? 224 LEU F CD1 1 
ATOM   1004 C CD2 . LEU A 1 153 ? 149.701 147.506 131.007 1.00 21.21  ? 224 LEU F CD2 1 
ATOM   1005 N N   . THR A 1 154 ? 151.787 143.555 131.058 1.00 21.25  ? 225 THR F N   1 
ATOM   1006 C CA  . THR A 1 154 ? 151.999 142.214 130.529 1.00 21.25  ? 225 THR F CA  1 
ATOM   1007 C C   . THR A 1 154 ? 151.075 141.970 129.344 1.00 21.25  ? 225 THR F C   1 
ATOM   1008 O O   . THR A 1 154 ? 149.870 142.218 129.432 1.00 21.25  ? 225 THR F O   1 
ATOM   1009 C CB  . THR A 1 154 ? 151.759 141.156 131.610 1.00 21.25  ? 225 THR F CB  1 
ATOM   1010 O OG1 . THR A 1 154 ? 152.641 141.391 132.715 1.00 21.25  ? 225 THR F OG1 1 
ATOM   1011 C CG2 . THR A 1 154 ? 152.010 139.761 131.058 1.00 21.25  ? 225 THR F CG2 1 
ATOM   1012 N N   . CYS A 1 155 ? 151.640 141.485 128.241 1.00 24.32  ? 226 CYS F N   1 
ATOM   1013 C CA  . CYS A 1 155 ? 150.873 141.083 127.069 1.00 24.32  ? 226 CYS F CA  1 
ATOM   1014 C C   . CYS A 1 155 ? 151.157 139.612 126.810 1.00 24.32  ? 226 CYS F C   1 
ATOM   1015 O O   . CYS A 1 155 ? 152.304 139.237 126.540 1.00 24.32  ? 226 CYS F O   1 
ATOM   1016 C CB  . CYS A 1 155 ? 151.237 141.936 125.851 1.00 24.32  ? 226 CYS F CB  1 
ATOM   1017 S SG  . CYS A 1 155 ? 150.069 141.833 124.475 1.00 24.32  ? 226 CYS F SG  1 
ATOM   1018 N N   . LEU A 1 156 ? 150.120 138.781 126.901 1.00 25.26  ? 227 LEU F N   1 
ATOM   1019 C CA  . LEU A 1 156 ? 150.269 137.334 126.802 1.00 25.26  ? 227 LEU F CA  1 
ATOM   1020 C C   . LEU A 1 156 ? 149.331 136.806 125.729 1.00 25.26  ? 227 LEU F C   1 
ATOM   1021 O O   . LEU A 1 156 ? 148.110 136.925 125.857 1.00 25.26  ? 227 LEU F O   1 
ATOM   1022 C CB  . LEU A 1 156 ? 149.979 136.661 128.147 1.00 25.26  ? 227 LEU F CB  1 
ATOM   1023 C CG  . LEU A 1 156 ? 149.738 135.149 128.141 1.00 25.26  ? 227 LEU F CG  1 
ATOM   1024 C CD1 . LEU A 1 156 ? 150.945 134.404 127.598 1.00 25.26  ? 227 LEU F CD1 1 
ATOM   1025 C CD2 . LEU A 1 156 ? 149.384 134.658 129.537 1.00 25.26  ? 227 LEU F CD2 1 
ATOM   1026 N N   . VAL A 1 157 ? 149.896 136.217 124.682 1.00 26.78  ? 228 VAL F N   1 
ATOM   1027 C CA  . VAL A 1 157 ? 149.113 135.584 123.629 1.00 26.78  ? 228 VAL F CA  1 
ATOM   1028 C C   . VAL A 1 157 ? 149.170 134.078 123.842 1.00 26.78  ? 228 VAL F C   1 
ATOM   1029 O O   . VAL A 1 157 ? 150.258 133.492 123.922 1.00 26.78  ? 228 VAL F O   1 
ATOM   1030 C CB  . VAL A 1 157 ? 149.616 135.977 122.231 1.00 26.78  ? 228 VAL F CB  1 
ATOM   1031 C CG1 . VAL A 1 157 ? 149.095 137.350 121.859 1.00 26.78  ? 228 VAL F CG1 1 
ATOM   1032 C CG2 . VAL A 1 157 ? 151.129 135.972 122.186 1.00 26.78  ? 228 VAL F CG2 1 
ATOM   1033 N N   . VAL A 1 158 ? 147.997 133.456 123.948 1.00 28.39  ? 229 VAL F N   1 
ATOM   1034 C CA  . VAL A 1 158 ? 147.883 132.029 124.209 1.00 28.39  ? 229 VAL F CA  1 
ATOM   1035 C C   . VAL A 1 158 ? 147.073 131.387 123.088 1.00 28.39  ? 229 VAL F C   1 
ATOM   1036 O O   . VAL A 1 158 ? 146.501 132.066 122.232 1.00 28.39  ? 229 VAL F O   1 
ATOM   1037 C CB  . VAL A 1 158 ? 147.251 131.731 125.584 1.00 28.39  ? 229 VAL F CB  1 
ATOM   1038 C CG1 . VAL A 1 158 ? 148.216 132.085 126.699 1.00 28.39  ? 229 VAL F CG1 1 
ATOM   1039 C CG2 . VAL A 1 158 ? 145.957 132.499 125.752 1.00 28.39  ? 229 VAL F CG2 1 
ATOM   1040 N N   . ASP A 1 159 ? 147.031 130.052 123.114 1.00 31.99  ? 230 ASP F N   1 
ATOM   1041 C CA  . ASP A 1 159 ? 146.426 129.245 122.054 1.00 31.99  ? 230 ASP F CA  1 
ATOM   1042 C C   . ASP A 1 159 ? 147.085 129.514 120.704 1.00 31.99  ? 230 ASP F C   1 
ATOM   1043 O O   . ASP A 1 159 ? 146.415 129.563 119.669 1.00 31.99  ? 230 ASP F O   1 
ATOM   1044 C CB  . ASP A 1 159 ? 144.913 129.467 121.973 1.00 31.99  ? 230 ASP F CB  1 
ATOM   1045 C CG  . ASP A 1 159 ? 144.199 129.074 123.252 1.00 31.99  ? 230 ASP F CG  1 
ATOM   1046 O OD1 . ASP A 1 159 ? 144.582 128.051 123.857 1.00 31.99  ? 230 ASP F OD1 1 
ATOM   1047 O OD2 . ASP A 1 159 ? 143.260 129.791 123.655 1.00 31.99  ? 230 ASP F OD2 1 
ATOM   1048 N N   . LEU A 1 160 ? 148.404 129.687 120.713 1.00 40.00  ? 231 LEU F N   1 
ATOM   1049 C CA  . LEU A 1 160 ? 149.171 129.931 119.501 1.00 40.00  ? 231 LEU F CA  1 
ATOM   1050 C C   . LEU A 1 160 ? 149.659 128.609 118.921 1.00 40.00  ? 231 LEU F C   1 
ATOM   1051 O O   . LEU A 1 160 ? 150.054 127.701 119.659 1.00 40.00  ? 231 LEU F O   1 
ATOM   1052 C CB  . LEU A 1 160 ? 150.353 130.855 119.795 1.00 40.00  ? 231 LEU F CB  1 
ATOM   1053 C CG  . LEU A 1 160 ? 151.181 131.353 118.611 1.00 40.00  ? 231 LEU F CG  1 
ATOM   1054 C CD1 . LEU A 1 160 ? 151.308 132.866 118.653 1.00 40.00  ? 231 LEU F CD1 1 
ATOM   1055 C CD2 . LEU A 1 160 ? 152.551 130.703 118.619 1.00 40.00  ? 231 LEU F CD2 1 
ATOM   1056 N N   . GLU A 1 161 ? 149.629 128.506 117.592 1.00 46.03  ? 232 GLU F N   1 
ATOM   1057 C CA  . GLU A 1 161 ? 149.932 127.238 116.935 1.00 46.03  ? 232 GLU F CA  1 
ATOM   1058 C C   . GLU A 1 161 ? 151.436 127.007 116.821 1.00 46.03  ? 232 GLU F C   1 
ATOM   1059 O O   . GLU A 1 161 ? 151.977 126.065 117.411 1.00 46.03  ? 232 GLU F O   1 
ATOM   1060 C CB  . GLU A 1 161 ? 149.276 127.197 115.552 1.00 46.03  ? 232 GLU F CB  1 
ATOM   1061 C CG  . GLU A 1 161 ? 149.480 125.888 114.804 1.00 46.03  ? 232 GLU F CG  1 
ATOM   1062 C CD  . GLU A 1 161 ? 148.737 124.727 115.438 1.00 46.03  ? 232 GLU F CD  1 
ATOM   1063 O OE1 . GLU A 1 161 ? 147.767 124.973 116.185 1.00 46.03  ? 232 GLU F OE1 1 
ATOM   1064 O OE2 . GLU A 1 161 ? 149.124 123.566 115.189 1.00 46.03  ? 232 GLU F OE2 1 
ATOM   1065 N N   . SER A 1 162 ? 152.128 127.860 116.068 1.00 45.90  ? 233 SER F N   1 
ATOM   1066 C CA  . SER A 1 162 ? 153.553 127.697 115.810 1.00 45.90  ? 233 SER F CA  1 
ATOM   1067 C C   . SER A 1 162 ? 154.281 128.986 116.155 1.00 45.90  ? 233 SER F C   1 
ATOM   1068 O O   . SER A 1 162 ? 153.869 130.069 115.727 1.00 45.90  ? 233 SER F O   1 
ATOM   1069 C CB  . SER A 1 162 ? 153.812 127.316 114.349 1.00 45.90  ? 233 SER F CB  1 
ATOM   1070 O OG  . SER A 1 162 ? 153.181 126.090 114.021 1.00 45.90  ? 233 SER F OG  1 
ATOM   1071 N N   . GLU A 1 163 ? 155.364 128.865 116.918 1.00 46.65  ? 234 GLU F N   1 
ATOM   1072 C CA  . GLU A 1 163 ? 156.155 130.017 117.351 1.00 46.65  ? 234 GLU F CA  1 
ATOM   1073 C C   . GLU A 1 163 ? 157.193 130.415 116.304 1.00 46.65  ? 234 GLU F C   1 
ATOM   1074 O O   . GLU A 1 163 ? 158.382 130.547 116.592 1.00 46.65  ? 234 GLU F O   1 
ATOM   1075 C CB  . GLU A 1 163 ? 156.815 129.712 118.691 1.00 46.65  ? 234 GLU F CB  1 
ATOM   1076 C CG  . GLU A 1 163 ? 157.548 128.378 118.734 1.00 46.65  ? 234 GLU F CG  1 
ATOM   1077 C CD  . GLU A 1 163 ? 158.207 128.115 120.074 1.00 46.65  ? 234 GLU F CD  1 
ATOM   1078 O OE1 . GLU A 1 163 ? 158.020 128.931 121.000 1.00 46.65  ? 234 GLU F OE1 1 
ATOM   1079 O OE2 . GLU A 1 163 ? 158.912 127.092 120.200 1.00 46.65  ? 234 GLU F OE2 1 
ATOM   1080 N N   . LYS A 1 164 ? 156.740 130.620 115.069 1.00 43.06  ? 235 LYS F N   1 
ATOM   1081 C CA  . LYS A 1 164 ? 157.610 131.007 113.967 1.00 43.06  ? 235 LYS F CA  1 
ATOM   1082 C C   . LYS A 1 164 ? 157.057 132.261 113.309 1.00 43.06  ? 235 LYS F C   1 
ATOM   1083 O O   . LYS A 1 164 ? 155.866 132.321 112.987 1.00 43.06  ? 235 LYS F O   1 
ATOM   1084 C CB  . LYS A 1 164 ? 157.738 129.879 112.937 1.00 43.06  ? 235 LYS F CB  1 
ATOM   1085 C CG  . LYS A 1 164 ? 158.296 128.582 113.502 1.00 43.06  ? 235 LYS F CG  1 
ATOM   1086 C CD  . LYS A 1 164 ? 159.685 128.785 114.086 1.00 43.06  ? 235 LYS F CD  1 
ATOM   1087 C CE  . LYS A 1 164 ? 160.234 127.491 114.667 1.00 43.06  ? 235 LYS F CE  1 
ATOM   1088 N NZ  . LYS A 1 164 ? 161.589 127.677 115.254 1.00 43.06  ? 235 LYS F NZ  1 
ATOM   1089 N N   . ASN A 1 165 ? 157.926 133.255 113.112 1.00 37.71  ? 236 ASN F N   1 
ATOM   1090 C CA  . ASN A 1 165 ? 157.566 134.525 112.475 1.00 37.71  ? 236 ASN F CA  1 
ATOM   1091 C C   . ASN A 1 165 ? 156.457 135.251 113.233 1.00 37.71  ? 236 ASN F C   1 
ATOM   1092 O O   . ASN A 1 165 ? 155.662 135.984 112.640 1.00 37.71  ? 236 ASN F O   1 
ATOM   1093 C CB  . ASN A 1 165 ? 157.167 134.320 111.010 1.00 37.71  ? 236 ASN F CB  1 
ATOM   1094 C CG  . ASN A 1 165 ? 158.280 133.708 110.184 1.00 37.71  ? 236 ASN F CG  1 
ATOM   1095 O OD1 . ASN A 1 165 ? 158.127 132.624 109.621 1.00 37.71  ? 236 ASN F OD1 1 
ATOM   1096 N ND2 . ASN A 1 165 ? 159.410 134.401 110.106 1.00 37.71  ? 236 ASN F ND2 1 
ATOM   1097 N N   . VAL A 1 166 ? 156.402 135.063 114.549 1.00 38.96  ? 237 VAL F N   1 
ATOM   1098 C CA  . VAL A 1 166 ? 155.429 135.723 115.412 1.00 38.96  ? 237 VAL F CA  1 
ATOM   1099 C C   . VAL A 1 166 ? 156.178 136.710 116.292 1.00 38.96  ? 237 VAL F C   1 
ATOM   1100 O O   . VAL A 1 166 ? 157.148 136.336 116.964 1.00 38.96  ? 237 VAL F O   1 
ATOM   1101 C CB  . VAL A 1 166 ? 154.654 134.708 116.269 1.00 38.96  ? 237 VAL F CB  1 
ATOM   1102 C CG1 . VAL A 1 166 ? 153.520 135.396 117.015 1.00 38.96  ? 237 VAL F CG1 1 
ATOM   1103 C CG2 . VAL A 1 166 ? 154.132 133.573 115.409 1.00 38.96  ? 237 VAL F CG2 1 
ATOM   1104 N N   . ASN A 1 167 ? 155.737 137.966 116.295 1.00 35.23  ? 238 ASN F N   1 
ATOM   1105 C CA  . ASN A 1 167 ? 156.431 138.965 117.097 1.00 35.23  ? 238 ASN F CA  1 
ATOM   1106 C C   . ASN A 1 167 ? 155.441 139.975 117.659 1.00 35.23  ? 238 ASN F C   1 
ATOM   1107 O O   . ASN A 1 167 ? 154.332 140.150 117.147 1.00 35.23  ? 238 ASN F O   1 
ATOM   1108 C CB  . ASN A 1 167 ? 157.532 139.674 116.297 1.00 35.23  ? 238 ASN F CB  1 
ATOM   1109 C CG  . ASN A 1 167 ? 157.097 140.043 114.894 1.00 35.23  ? 238 ASN F CG  1 
ATOM   1110 O OD1 . ASN A 1 167 ? 155.906 140.119 114.594 1.00 35.23  ? 238 ASN F OD1 1 
ATOM   1111 N ND2 . ASN A 1 167 ? 158.073 140.275 114.023 1.00 35.23  ? 238 ASN F ND2 1 
ATOM   1112 N N   . VAL A 1 168 ? 155.872 140.648 118.724 1.00 32.44  ? 239 VAL F N   1 
ATOM   1113 C CA  . VAL A 1 168 ? 155.048 141.599 119.459 1.00 32.44  ? 239 VAL F CA  1 
ATOM   1114 C C   . VAL A 1 168 ? 155.674 142.981 119.340 1.00 32.44  ? 239 VAL F C   1 
ATOM   1115 O O   . VAL A 1 168 ? 156.860 143.161 119.638 1.00 32.44  ? 239 VAL F O   1 
ATOM   1116 C CB  . VAL A 1 168 ? 154.898 141.194 120.937 1.00 32.44  ? 239 VAL F CB  1 
ATOM   1117 C CG1 . VAL A 1 168 ? 154.096 142.240 121.694 1.00 32.44  ? 239 VAL F CG1 1 
ATOM   1118 C CG2 . VAL A 1 168 ? 154.242 139.826 121.048 1.00 32.44  ? 239 VAL F CG2 1 
ATOM   1119 N N   . THR A 1 169 ? 154.873 143.949 118.906 1.00 32.58  ? 240 THR F N   1 
ATOM   1120 C CA  . THR A 1 169 ? 155.275 145.345 118.813 1.00 32.58  ? 240 THR F CA  1 
ATOM   1121 C C   . THR A 1 169 ? 154.438 146.170 119.781 1.00 32.58  ? 240 THR F C   1 
ATOM   1122 O O   . THR A 1 169 ? 153.212 146.019 119.838 1.00 32.58  ? 240 THR F O   1 
ATOM   1123 C CB  . THR A 1 169 ? 155.108 145.874 117.386 1.00 32.58  ? 240 THR F CB  1 
ATOM   1124 O OG1 . THR A 1 169 ? 153.732 145.781 116.997 1.00 32.58  ? 240 THR F OG1 1 
ATOM   1125 C CG2 . THR A 1 169 ? 155.960 145.069 116.416 1.00 32.58  ? 240 THR F CG2 1 
ATOM   1126 N N   . TRP A 1 170 ? 155.097 147.038 120.539 1.00 30.43  ? 241 TRP F N   1 
ATOM   1127 C CA  . TRP A 1 170 ? 154.432 147.873 121.529 1.00 30.43  ? 241 TRP F CA  1 
ATOM   1128 C C   . TRP A 1 170 ? 154.389 149.311 121.031 1.00 30.43  ? 241 TRP F C   1 
ATOM   1129 O O   . TRP A 1 170 ? 155.435 149.932 120.817 1.00 30.43  ? 241 TRP F O   1 
ATOM   1130 C CB  . TRP A 1 170 ? 155.137 147.784 122.882 1.00 30.43  ? 241 TRP F CB  1 
ATOM   1131 C CG  . TRP A 1 170 ? 154.661 146.631 123.705 1.00 30.43  ? 241 TRP F CG  1 
ATOM   1132 C CD1 . TRP A 1 170 ? 155.046 145.327 123.593 1.00 30.43  ? 241 TRP F CD1 1 
ATOM   1133 C CD2 . TRP A 1 170 ? 153.698 146.676 124.765 1.00 30.43  ? 241 TRP F CD2 1 
ATOM   1134 N NE1 . TRP A 1 170 ? 154.385 144.558 124.521 1.00 30.43  ? 241 TRP F NE1 1 
ATOM   1135 C CE2 . TRP A 1 170 ? 153.552 145.363 125.253 1.00 30.43  ? 241 TRP F CE2 1 
ATOM   1136 C CE3 . TRP A 1 170 ? 152.948 147.700 125.351 1.00 30.43  ? 241 TRP F CE3 1 
ATOM   1137 C CZ2 . TRP A 1 170 ? 152.689 145.047 126.299 1.00 30.43  ? 241 TRP F CZ2 1 
ATOM   1138 C CZ3 . TRP A 1 170 ? 152.090 147.384 126.389 1.00 30.43  ? 241 TRP F CZ3 1 
ATOM   1139 C CH2 . TRP A 1 170 ? 151.967 146.069 126.851 1.00 30.43  ? 241 TRP F CH2 1 
ATOM   1140 N N   . ASN A 1 171 ? 153.177 149.829 120.850 1.00 37.47  ? 242 ASN F N   1 
ATOM   1141 C CA  . ASN A 1 171 ? 152.964 151.214 120.449 1.00 37.47  ? 242 ASN F CA  1 
ATOM   1142 C C   . ASN A 1 171 ? 152.832 152.055 121.713 1.00 37.47  ? 242 ASN F C   1 
ATOM   1143 O O   . ASN A 1 171 ? 151.884 151.883 122.488 1.00 37.47  ? 242 ASN F O   1 
ATOM   1144 C CB  . ASN A 1 171 ? 151.724 151.335 119.567 1.00 37.47  ? 242 ASN F CB  1 
ATOM   1145 C CG  . ASN A 1 171 ? 151.641 152.671 118.849 1.00 37.47  ? 242 ASN F CG  1 
ATOM   1146 O OD1 . ASN A 1 171 ? 152.181 153.676 119.311 1.00 37.47  ? 242 ASN F OD1 1 
ATOM   1147 N ND2 . ASN A 1 171 ? 150.960 152.685 117.709 1.00 37.47  ? 242 ASN F ND2 1 
ATOM   1148 N N   . GLN A 1 172 ? 153.792 152.959 121.923 1.00 43.30  ? 243 GLN F N   1 
ATOM   1149 C CA  . GLN A 1 172 ? 153.774 153.812 123.103 1.00 43.30  ? 243 GLN F CA  1 
ATOM   1150 C C   . GLN A 1 172 ? 152.662 154.850 123.049 1.00 43.30  ? 243 GLN F C   1 
ATOM   1151 O O   . GLN A 1 172 ? 152.266 155.366 124.100 1.00 43.30  ? 243 GLN F O   1 
ATOM   1152 C CB  . GLN A 1 172 ? 155.127 154.506 123.268 1.00 43.30  ? 243 GLN F CB  1 
ATOM   1153 C CG  . GLN A 1 172 ? 155.500 154.813 124.708 1.00 43.30  ? 243 GLN F CG  1 
ATOM   1154 C CD  . GLN A 1 172 ? 155.875 153.568 125.490 1.00 43.30  ? 243 GLN F CD  1 
ATOM   1155 O OE1 . GLN A 1 172 ? 156.190 152.528 124.911 1.00 43.30  ? 243 GLN F OE1 1 
ATOM   1156 N NE2 . GLN A 1 172 ? 155.844 153.669 126.814 1.00 43.30  ? 243 GLN F NE2 1 
ATOM   1157 N N   . GLU A 1 173 ? 152.153 155.161 121.855 1.00 50.01  ? 244 GLU F N   1 
ATOM   1158 C CA  . GLU A 1 173 ? 151.085 156.146 121.654 1.00 50.01  ? 244 GLU F CA  1 
ATOM   1159 C C   . GLU A 1 173 ? 151.566 157.472 122.234 1.00 50.01  ? 244 GLU F C   1 
ATOM   1160 O O   . GLU A 1 173 ? 152.527 158.045 121.692 1.00 50.01  ? 244 GLU F O   1 
ATOM   1161 C CB  . GLU A 1 173 ? 149.780 155.590 122.231 1.00 50.01  ? 244 GLU F CB  1 
ATOM   1162 C CG  . GLU A 1 173 ? 148.536 156.374 121.842 1.00 50.01  ? 244 GLU F CG  1 
ATOM   1163 C CD  . GLU A 1 173 ? 147.265 155.756 122.393 1.00 50.01  ? 244 GLU F CD  1 
ATOM   1164 O OE1 . GLU A 1 173 ? 147.353 154.695 123.046 1.00 50.01  ? 244 GLU F OE1 1 
ATOM   1165 O OE2 . GLU A 1 173 ? 146.179 156.332 122.174 1.00 50.01  ? 244 GLU F OE2 1 
ATOM   1166 N N   . LYS A 1 174 ? 150.956 157.994 123.295 1.00 50.28  ? 245 LYS F N   1 
ATOM   1167 C CA  . LYS A 1 174 ? 151.440 159.223 123.905 1.00 50.28  ? 245 LYS F CA  1 
ATOM   1168 C C   . LYS A 1 174 ? 152.777 158.981 124.596 1.00 50.28  ? 245 LYS F C   1 
ATOM   1169 O O   . LYS A 1 174 ? 153.020 157.905 125.150 1.00 50.28  ? 245 LYS F O   1 
ATOM   1170 C CB  . LYS A 1 174 ? 150.415 159.757 124.904 1.00 50.28  ? 245 LYS F CB  1 
ATOM   1171 C CG  . LYS A 1 174 ? 149.034 159.980 124.308 1.00 50.28  ? 245 LYS F CG  1 
ATOM   1172 C CD  . LYS A 1 174 ? 148.039 160.439 125.361 1.00 50.28  ? 245 LYS F CD  1 
ATOM   1173 C CE  . LYS A 1 174 ? 146.650 160.615 124.769 1.00 50.28  ? 245 LYS F CE  1 
ATOM   1174 N NZ  . LYS A 1 174 ? 145.659 161.043 125.795 1.00 50.28  ? 245 LYS F NZ  1 
ATOM   1175 N N   . LYS A 1 175 ? 153.650 159.993 124.544 1.00 56.91  ? 246 LYS F N   1 
ATOM   1176 C CA  . LYS A 1 175 ? 154.999 159.949 125.105 1.00 56.91  ? 246 LYS F CA  1 
ATOM   1177 C C   . LYS A 1 175 ? 155.885 158.948 124.368 1.00 56.91  ? 246 LYS F C   1 
ATOM   1178 O O   . LYS A 1 175 ? 155.393 157.978 123.784 1.00 56.91  ? 246 LYS F O   1 
ATOM   1179 C CB  . LYS A 1 175 ? 154.961 159.623 126.603 1.00 56.91  ? 246 LYS F CB  1 
ATOM   1180 C CG  . LYS A 1 175 ? 154.195 160.634 127.442 1.00 56.91  ? 246 LYS F CG  1 
ATOM   1181 C CD  . LYS A 1 175 ? 154.883 161.989 127.443 1.00 56.91  ? 246 LYS F CD  1 
ATOM   1182 C CE  . LYS A 1 175 ? 156.271 161.900 128.058 1.00 56.91  ? 246 LYS F CE  1 
ATOM   1183 N NZ  . LYS A 1 175 ? 156.954 163.223 128.081 1.00 56.91  ? 246 LYS F NZ  1 
ATOM   1184 N N   . THR A 1 176 ? 157.196 159.182 124.383 1.00 71.21  ? 247 THR F N   1 
ATOM   1185 C CA  . THR A 1 176 ? 158.153 158.324 123.699 1.00 71.21  ? 247 THR F CA  1 
ATOM   1186 C C   . THR A 1 176 ? 159.303 157.986 124.635 1.00 71.21  ? 247 THR F C   1 
ATOM   1187 O O   . THR A 1 176 ? 159.822 158.858 125.338 1.00 71.21  ? 247 THR F O   1 
ATOM   1188 C CB  . THR A 1 176 ? 158.702 158.990 122.428 1.00 71.21  ? 247 THR F CB  1 
ATOM   1189 O OG1 . THR A 1 176 ? 159.260 160.268 122.758 1.00 71.21  ? 247 THR F OG1 1 
ATOM   1190 C CG2 . THR A 1 176 ? 157.598 159.171 121.396 1.00 71.21  ? 247 THR F CG2 1 
ATOM   1191 N N   . SER A 1 177 ? 159.698 156.714 124.636 1.00 79.25  ? 248 SER F N   1 
ATOM   1192 C CA  . SER A 1 177 ? 160.815 156.254 125.449 1.00 79.25  ? 248 SER F CA  1 
ATOM   1193 C C   . SER A 1 177 ? 161.314 154.932 124.887 1.00 79.25  ? 248 SER F C   1 
ATOM   1194 O O   . SER A 1 177 ? 160.611 154.252 124.134 1.00 79.25  ? 248 SER F O   1 
ATOM   1195 C CB  . SER A 1 177 ? 160.417 156.101 126.921 1.00 79.25  ? 248 SER F CB  1 
ATOM   1196 O OG  . SER A 1 177 ? 159.375 155.153 127.072 1.00 79.25  ? 248 SER F OG  1 
ATOM   1197 N N   . VAL A 1 178 ? 162.538 154.577 125.264 1.00 83.34  ? 249 VAL F N   1 
ATOM   1198 C CA  . VAL A 1 178 ? 163.141 153.312 124.859 1.00 83.34  ? 249 VAL F CA  1 
ATOM   1199 C C   . VAL A 1 178 ? 162.800 152.273 125.923 1.00 83.34  ? 249 VAL F C   1 
ATOM   1200 O O   . VAL A 1 178 ? 163.231 152.379 127.075 1.00 83.34  ? 249 VAL F O   1 
ATOM   1201 C CB  . VAL A 1 178 ? 164.656 153.445 124.659 1.00 83.34  ? 249 VAL F CB  1 
ATOM   1202 C CG1 . VAL A 1 178 ? 165.276 154.308 125.754 1.00 83.34  ? 249 VAL F CG1 1 
ATOM   1203 C CG2 . VAL A 1 178 ? 165.313 152.071 124.614 1.00 83.34  ? 249 VAL F CG2 1 
ATOM   1204 N N   . SER A 1 179 ? 162.008 151.275 125.542 1.00 71.72  ? 250 SER F N   1 
ATOM   1205 C CA  . SER A 1 179 ? 161.512 150.253 126.458 1.00 71.72  ? 250 SER F CA  1 
ATOM   1206 C C   . SER A 1 179 ? 161.649 148.867 125.841 1.00 71.72  ? 250 SER F C   1 
ATOM   1207 O O   . SER A 1 179 ? 160.708 148.071 125.824 1.00 71.72  ? 250 SER F O   1 
ATOM   1208 C CB  . SER A 1 179 ? 160.063 150.531 126.848 1.00 71.72  ? 250 SER F CB  1 
ATOM   1209 O OG  . SER A 1 179 ? 159.586 149.558 127.762 1.00 71.72  ? 250 SER F OG  1 
ATOM   1210 N N   . ALA A 1 180 ? 162.832 148.570 125.304 1.00 64.79  ? 251 ALA F N   1 
ATOM   1211 C CA  . ALA A 1 180 ? 163.091 147.245 124.755 1.00 64.79  ? 251 ALA F CA  1 
ATOM   1212 C C   . ALA A 1 180 ? 162.917 146.185 125.835 1.00 64.79  ? 251 ALA F C   1 
ATOM   1213 O O   . ALA A 1 180 ? 163.431 146.324 126.948 1.00 64.79  ? 251 ALA F O   1 
ATOM   1214 C CB  . ALA A 1 180 ? 164.501 147.182 124.167 1.00 64.79  ? 251 ALA F CB  1 
ATOM   1215 N N   . SER A 1 181 ? 162.188 145.123 125.502 1.00 49.63  ? 252 SER F N   1 
ATOM   1216 C CA  . SER A 1 181 ? 161.801 144.115 126.479 1.00 49.63  ? 252 SER F CA  1 
ATOM   1217 C C   . SER A 1 181 ? 161.970 142.735 125.854 1.00 49.63  ? 252 SER F C   1 
ATOM   1218 O O   . SER A 1 181 ? 162.574 142.580 124.788 1.00 49.63  ? 252 SER F O   1 
ATOM   1219 C CB  . SER A 1 181 ? 160.363 144.352 126.956 1.00 49.63  ? 252 SER F CB  1 
ATOM   1220 O OG  . SER A 1 181 ? 159.445 144.132 125.900 1.00 49.63  ? 252 SER F OG  1 
ATOM   1221 N N   . GLN A 1 182 ? 161.429 141.727 126.530 1.00 45.34  ? 253 GLN F N   1 
ATOM   1222 C CA  . GLN A 1 182 ? 161.496 140.344 126.087 1.00 45.34  ? 253 GLN F CA  1 
ATOM   1223 C C   . GLN A 1 182 ? 160.164 139.909 125.485 1.00 45.34  ? 253 GLN F C   1 
ATOM   1224 O O   . GLN A 1 182 ? 159.120 140.529 125.703 1.00 45.34  ? 253 GLN F O   1 
ATOM   1225 C CB  . GLN A 1 182 ? 161.870 139.416 127.248 1.00 45.34  ? 253 GLN F CB  1 
ATOM   1226 C CG  . GLN A 1 182 ? 163.184 139.757 127.939 1.00 45.34  ? 253 GLN F CG  1 
ATOM   1227 C CD  . GLN A 1 182 ? 163.038 140.865 128.967 1.00 45.34  ? 253 GLN F CD  1 
ATOM   1228 O OE1 . GLN A 1 182 ? 161.937 141.354 129.217 1.00 45.34  ? 253 GLN F OE1 1 
ATOM   1229 N NE2 . GLN A 1 182 ? 164.152 141.265 129.568 1.00 45.34  ? 253 GLN F NE2 1 
ATOM   1230 N N   . TRP A 1 183 ? 160.219 138.827 124.716 1.00 40.01  ? 254 TRP F N   1 
ATOM   1231 C CA  . TRP A 1 183 ? 159.066 138.223 124.054 1.00 40.01  ? 254 TRP F CA  1 
ATOM   1232 C C   . TRP A 1 183 ? 159.082 136.715 124.262 1.00 40.01  ? 254 TRP F C   1 
ATOM   1233 O O   . TRP A 1 183 ? 158.955 135.926 123.323 1.00 40.01  ? 254 TRP F O   1 
ATOM   1234 C CB  . TRP A 1 183 ? 159.040 138.579 122.568 1.00 40.01  ? 254 TRP F CB  1 
ATOM   1235 C CG  . TRP A 1 183 ? 160.327 138.292 121.843 1.00 40.01  ? 254 TRP F CG  1 
ATOM   1236 C CD1 . TRP A 1 183 ? 161.493 138.997 121.933 1.00 40.01  ? 254 TRP F CD1 1 
ATOM   1237 C CD2 . TRP A 1 183 ? 160.571 137.236 120.904 1.00 40.01  ? 254 TRP F CD2 1 
ATOM   1238 N NE1 . TRP A 1 183 ? 162.449 138.440 121.119 1.00 40.01  ? 254 TRP F NE1 1 
ATOM   1239 C CE2 . TRP A 1 183 ? 161.908 137.358 120.476 1.00 40.01  ? 254 TRP F CE2 1 
ATOM   1240 C CE3 . TRP A 1 183 ? 159.790 136.197 120.388 1.00 40.01  ? 254 TRP F CE3 1 
ATOM   1241 C CZ2 . TRP A 1 183 ? 162.481 136.482 119.556 1.00 40.01  ? 254 TRP F CZ2 1 
ATOM   1242 C CZ3 . TRP A 1 183 ? 160.361 135.327 119.476 1.00 40.01  ? 254 TRP F CZ3 1 
ATOM   1243 C CH2 . TRP A 1 183 ? 161.693 135.475 119.070 1.00 40.01  ? 254 TRP F CH2 1 
ATOM   1244 N N   . TYR A 1 184 ? 159.236 136.296 125.516 1.00 37.78  ? 255 TYR F N   1 
ATOM   1245 C CA  . TYR A 1 184 ? 159.619 134.916 125.786 1.00 37.78  ? 255 TYR F CA  1 
ATOM   1246 C C   . TYR A 1 184 ? 158.453 133.960 125.562 1.00 37.78  ? 255 TYR F C   1 
ATOM   1247 O O   . TYR A 1 184 ? 157.308 134.249 125.919 1.00 37.78  ? 255 TYR F O   1 
ATOM   1248 C CB  . TYR A 1 184 ? 160.163 134.775 127.210 1.00 37.78  ? 255 TYR F CB  1 
ATOM   1249 C CG  . TYR A 1 184 ? 159.216 135.187 128.315 1.00 37.78  ? 255 TYR F CG  1 
ATOM   1250 C CD1 . TYR A 1 184 ? 159.143 136.509 128.736 1.00 37.78  ? 255 TYR F CD1 1 
ATOM   1251 C CD2 . TYR A 1 184 ? 158.416 134.250 128.956 1.00 37.78  ? 255 TYR F CD2 1 
ATOM   1252 C CE1 . TYR A 1 184 ? 158.287 136.888 129.753 1.00 37.78  ? 255 TYR F CE1 1 
ATOM   1253 C CE2 . TYR A 1 184 ? 157.558 134.620 129.973 1.00 37.78  ? 255 TYR F CE2 1 
ATOM   1254 C CZ  . TYR A 1 184 ? 157.498 135.940 130.369 1.00 37.78  ? 255 TYR F CZ  1 
ATOM   1255 O OH  . TYR A 1 184 ? 156.644 136.312 131.381 1.00 37.78  ? 255 TYR F OH  1 
ATOM   1256 N N   . THR A 1 185 ? 158.759 132.809 124.971 1.00 41.89  ? 256 THR F N   1 
ATOM   1257 C CA  . THR A 1 185 ? 157.763 131.818 124.588 1.00 41.89  ? 256 THR F CA  1 
ATOM   1258 C C   . THR A 1 185 ? 157.905 130.581 125.464 1.00 41.89  ? 256 THR F C   1 
ATOM   1259 O O   . THR A 1 185 ? 159.019 130.090 125.678 1.00 41.89  ? 256 THR F O   1 
ATOM   1260 C CB  . THR A 1 185 ? 157.911 131.434 123.114 1.00 41.89  ? 256 THR F CB  1 
ATOM   1261 O OG1 . THR A 1 185 ? 159.100 130.653 122.941 1.00 41.89  ? 256 THR F OG1 1 
ATOM   1262 C CG2 . THR A 1 185 ? 158.008 132.680 122.249 1.00 41.89  ? 256 THR F CG2 1 
ATOM   1263 N N   . LYS A 1 186 ? 156.778 130.084 125.966 1.00 43.23  ? 257 LYS F N   1 
ATOM   1264 C CA  . LYS A 1 186 ? 156.733 128.874 126.775 1.00 43.23  ? 257 LYS F CA  1 
ATOM   1265 C C   . LYS A 1 186 ? 155.780 127.877 126.133 1.00 43.23  ? 257 LYS F C   1 
ATOM   1266 O O   . LYS A 1 186 ? 154.639 128.222 125.807 1.00 43.23  ? 257 LYS F O   1 
ATOM   1267 C CB  . LYS A 1 186 ? 156.296 129.185 128.209 1.00 43.23  ? 257 LYS F CB  1 
ATOM   1268 C CG  . LYS A 1 186 ? 157.246 130.104 128.958 1.00 43.23  ? 257 LYS F CG  1 
ATOM   1269 C CD  . LYS A 1 186 ? 158.648 129.517 129.014 1.00 43.23  ? 257 LYS F CD  1 
ATOM   1270 C CE  . LYS A 1 186 ? 159.610 130.448 129.733 1.00 43.23  ? 257 LYS F CE  1 
ATOM   1271 N NZ  . LYS A 1 186 ? 160.991 129.892 129.775 1.00 43.23  ? 257 LYS F NZ  1 
ATOM   1272 N N   . HIS A 1 187 ? 156.245 126.643 125.962 1.00 47.35  ? 258 HIS F N   1 
ATOM   1273 C CA  . HIS A 1 187 ? 155.449 125.591 125.342 1.00 47.35  ? 258 HIS F CA  1 
ATOM   1274 C C   . HIS A 1 187 ? 154.719 124.808 126.427 1.00 47.35  ? 258 HIS F C   1 
ATOM   1275 O O   . HIS A 1 187 ? 155.350 124.268 127.342 1.00 47.35  ? 258 HIS F O   1 
ATOM   1276 C CB  . HIS A 1 187 ? 156.334 124.665 124.509 1.00 47.35  ? 258 HIS F CB  1 
ATOM   1277 C CG  . HIS A 1 187 ? 155.571 123.630 123.742 1.00 47.35  ? 258 HIS F CG  1 
ATOM   1278 N ND1 . HIS A 1 187 ? 154.668 123.954 122.752 1.00 47.35  ? 258 HIS F ND1 1 
ATOM   1279 C CD2 . HIS A 1 187 ? 155.576 122.278 123.818 1.00 47.35  ? 258 HIS F CD2 1 
ATOM   1280 C CE1 . HIS A 1 187 ? 154.151 122.846 122.251 1.00 47.35  ? 258 HIS F CE1 1 
ATOM   1281 N NE2 . HIS A 1 187 ? 154.684 121.816 122.881 1.00 47.35  ? 258 HIS F NE2 1 
ATOM   1282 N N   . HIS A 1 188 ? 153.394 124.749 126.322 1.00 43.17  ? 259 HIS F N   1 
ATOM   1283 C CA  . HIS A 1 188 ? 152.573 124.048 127.295 1.00 43.17  ? 259 HIS F CA  1 
ATOM   1284 C C   . HIS A 1 188 ? 152.487 122.564 126.941 1.00 43.17  ? 259 HIS F C   1 
ATOM   1285 O O   . HIS A 1 188 ? 153.038 122.101 125.940 1.00 43.17  ? 259 HIS F O   1 
ATOM   1286 C CB  . HIS A 1 188 ? 151.186 124.682 127.372 1.00 43.17  ? 259 HIS F CB  1 
ATOM   1287 C CG  . HIS A 1 188 ? 151.203 126.123 127.776 1.00 43.17  ? 259 HIS F CG  1 
ATOM   1288 N ND1 . HIS A 1 188 ? 150.264 127.031 127.336 1.00 43.17  ? 259 HIS F ND1 1 
ATOM   1289 C CD2 . HIS A 1 188 ? 152.044 126.813 128.583 1.00 43.17  ? 259 HIS F CD2 1 
ATOM   1290 C CE1 . HIS A 1 188 ? 150.527 128.219 127.852 1.00 43.17  ? 259 HIS F CE1 1 
ATOM   1291 N NE2 . HIS A 1 188 ? 151.602 128.114 128.612 1.00 43.17  ? 259 HIS F NE2 1 
ATOM   1292 N N   . ASN A 1 189 ? 151.783 121.805 127.779 1.00 51.17  ? 260 ASN F N   1 
ATOM   1293 C CA  . ASN A 1 189 ? 151.644 120.367 127.606 1.00 51.17  ? 260 ASN F CA  1 
ATOM   1294 C C   . ASN A 1 189 ? 150.336 119.973 126.930 1.00 51.17  ? 260 ASN F C   1 
ATOM   1295 O O   . ASN A 1 189 ? 150.052 118.778 126.804 1.00 51.17  ? 260 ASN F O   1 
ATOM   1296 C CB  . ASN A 1 189 ? 151.764 119.661 128.958 1.00 51.17  ? 260 ASN F CB  1 
ATOM   1297 C CG  . ASN A 1 189 ? 153.106 119.900 129.622 1.00 51.17  ? 260 ASN F CG  1 
ATOM   1298 O OD1 . ASN A 1 189 ? 154.118 120.098 128.950 1.00 51.17  ? 260 ASN F OD1 1 
ATOM   1299 N ND2 . ASN A 1 189 ? 153.121 119.881 130.950 1.00 51.17  ? 260 ASN F ND2 1 
ATOM   1300 N N   . ASN A 1 190 ? 149.536 120.944 126.494 1.00 46.43  ? 261 ASN F N   1 
ATOM   1301 C CA  . ASN A 1 190 ? 148.274 120.682 125.809 1.00 46.43  ? 261 ASN F CA  1 
ATOM   1302 C C   . ASN A 1 190 ? 148.360 121.042 124.328 1.00 46.43  ? 261 ASN F C   1 
ATOM   1303 O O   . ASN A 1 190 ? 147.413 121.573 123.745 1.00 46.43  ? 261 ASN F O   1 
ATOM   1304 C CB  . ASN A 1 190 ? 147.124 121.430 126.481 1.00 46.43  ? 261 ASN F CB  1 
ATOM   1305 C CG  . ASN A 1 190 ? 147.412 122.908 126.667 1.00 46.43  ? 261 ASN F CG  1 
ATOM   1306 O OD1 . ASN A 1 190 ? 148.410 123.428 126.170 1.00 46.43  ? 261 ASN F OD1 1 
ATOM   1307 N ND2 . ASN A 1 190 ? 146.530 123.595 127.387 1.00 46.43  ? 261 ASN F ND2 1 
ATOM   1308 N N   . ALA A 1 191 ? 149.513 120.758 123.715 1.00 47.84  ? 262 ALA F N   1 
ATOM   1309 C CA  . ALA A 1 191 ? 149.752 121.002 122.290 1.00 47.84  ? 262 ALA F CA  1 
ATOM   1310 C C   . ALA A 1 191 ? 149.581 122.474 121.924 1.00 47.84  ? 262 ALA F C   1 
ATOM   1311 O O   . ALA A 1 191 ? 149.212 122.805 120.795 1.00 47.84  ? 262 ALA F O   1 
ATOM   1312 C CB  . ALA A 1 191 ? 148.853 120.124 121.414 1.00 47.84  ? 262 ALA F CB  1 
ATOM   1313 N N   . THR A 1 192 ? 149.850 123.367 122.874 1.00 42.04  ? 263 THR F N   1 
ATOM   1314 C CA  . THR A 1 192 ? 149.756 124.801 122.645 1.00 42.04  ? 263 THR F CA  1 
ATOM   1315 C C   . THR A 1 192 ? 150.964 125.486 123.266 1.00 42.04  ? 263 THR F C   1 
ATOM   1316 O O   . THR A 1 192 ? 151.608 124.954 124.174 1.00 42.04  ? 263 THR F O   1 
ATOM   1317 C CB  . THR A 1 192 ? 148.464 125.399 123.225 1.00 42.04  ? 263 THR F CB  1 
ATOM   1318 O OG1 . THR A 1 192 ? 148.364 125.072 124.616 1.00 42.04  ? 263 THR F OG1 1 
ATOM   1319 C CG2 . THR A 1 192 ? 147.240 124.867 122.489 1.00 42.04  ? 263 THR F CG2 1 
ATOM   1320 N N   . THR A 1 193 ? 151.269 126.678 122.759 1.00 40.66  ? 264 THR F N   1 
ATOM   1321 C CA  . THR A 1 193 ? 152.363 127.489 123.268 1.00 40.66  ? 264 THR F CA  1 
ATOM   1322 C C   . THR A 1 193 ? 151.881 128.920 123.462 1.00 40.66  ? 264 THR F C   1 
ATOM   1323 O O   . THR A 1 193 ? 150.937 129.375 122.810 1.00 40.66  ? 264 THR F O   1 
ATOM   1324 C CB  . THR A 1 193 ? 153.577 127.463 122.326 1.00 40.66  ? 264 THR F CB  1 
ATOM   1325 O OG1 . THR A 1 193 ? 154.588 128.349 122.821 1.00 40.66  ? 264 THR F OG1 1 
ATOM   1326 C CG2 . THR A 1 193 ? 153.175 127.889 120.923 1.00 40.66  ? 264 THR F CG2 1 
ATOM   1327 N N   . SER A 1 194 ? 152.542 129.628 124.375 1.00 36.31  ? 265 SER F N   1 
ATOM   1328 C CA  . SER A 1 194 ? 152.177 130.992 124.721 1.00 36.31  ? 265 SER F CA  1 
ATOM   1329 C C   . SER A 1 194 ? 153.396 131.893 124.603 1.00 36.31  ? 265 SER F C   1 
ATOM   1330 O O   . SER A 1 194 ? 154.535 131.446 124.753 1.00 36.31  ? 265 SER F O   1 
ATOM   1331 C CB  . SER A 1 194 ? 151.605 131.076 126.141 1.00 36.31  ? 265 SER F CB  1 
ATOM   1332 O OG  . SER A 1 194 ? 152.549 130.628 127.098 1.00 36.31  ? 265 SER F OG  1 
ATOM   1333 N N   . ILE A 1 195 ? 153.145 133.169 124.319 1.00 32.51  ? 266 ILE F N   1 
ATOM   1334 C CA  . ILE A 1 195 ? 154.196 134.177 124.222 1.00 32.51  ? 266 ILE F CA  1 
ATOM   1335 C C   . ILE A 1 195 ? 153.852 135.317 125.169 1.00 32.51  ? 266 ILE F C   1 
ATOM   1336 O O   . ILE A 1 195 ? 152.740 135.857 125.119 1.00 32.51  ? 266 ILE F O   1 
ATOM   1337 C CB  . ILE A 1 195 ? 154.365 134.693 122.781 1.00 32.51  ? 266 ILE F CB  1 
ATOM   1338 C CG1 . ILE A 1 195 ? 154.520 133.525 121.805 1.00 32.51  ? 266 ILE F CG1 1 
ATOM   1339 C CG2 . ILE A 1 195 ? 155.558 135.632 122.688 1.00 32.51  ? 266 ILE F CG2 1 
ATOM   1340 C CD1 . ILE A 1 195 ? 154.684 133.952 120.362 1.00 32.51  ? 266 ILE F CD1 1 
ATOM   1341 N N   . THR A 1 196 ? 154.805 135.689 126.021 1.00 32.35  ? 267 THR F N   1 
ATOM   1342 C CA  . THR A 1 196 ? 154.600 136.711 127.037 1.00 32.35  ? 267 THR F CA  1 
ATOM   1343 C C   . THR A 1 196 ? 155.648 137.804 126.885 1.00 32.35  ? 267 THR F C   1 
ATOM   1344 O O   . THR A 1 196 ? 156.843 137.514 126.743 1.00 32.35  ? 267 THR F O   1 
ATOM   1345 C CB  . THR A 1 196 ? 154.674 136.114 128.445 1.00 32.35  ? 267 THR F CB  1 
ATOM   1346 O OG1 . THR A 1 196 ? 153.948 134.880 128.484 1.00 32.35  ? 267 THR F OG1 1 
ATOM   1347 C CG2 . THR A 1 196 ? 154.078 137.077 129.461 1.00 32.35  ? 267 THR F CG2 1 
ATOM   1348 N N   . SER A 1 197 ? 155.193 139.057 126.919 1.00 30.66  ? 268 SER F N   1 
ATOM   1349 C CA  . SER A 1 197 ? 156.063 140.224 126.870 1.00 30.66  ? 268 SER F CA  1 
ATOM   1350 C C   . SER A 1 197 ? 155.705 141.155 128.019 1.00 30.66  ? 268 SER F C   1 
ATOM   1351 O O   . SER A 1 197 ? 154.534 141.504 128.197 1.00 30.66  ? 268 SER F O   1 
ATOM   1352 C CB  . SER A 1 197 ? 155.933 140.957 125.531 1.00 30.66  ? 268 SER F CB  1 
ATOM   1353 O OG  . SER A 1 197 ? 156.776 142.096 125.489 1.00 30.66  ? 268 SER F OG  1 
ATOM   1354 N N   . ILE A 1 198 ? 156.710 141.563 128.790 1.00 28.98  ? 269 ILE F N   1 
ATOM   1355 C CA  . ILE A 1 198 ? 156.515 142.428 129.948 1.00 28.98  ? 269 ILE F CA  1 
ATOM   1356 C C   . ILE A 1 198 ? 157.289 143.720 129.727 1.00 28.98  ? 269 ILE F C   1 
ATOM   1357 O O   . ILE A 1 198 ? 158.495 143.691 129.455 1.00 28.98  ? 269 ILE F O   1 
ATOM   1358 C CB  . ILE A 1 198 ? 156.952 141.738 131.254 1.00 28.98  ? 269 ILE F CB  1 
ATOM   1359 C CG1 . ILE A 1 198 ? 158.292 141.023 131.067 1.00 28.98  ? 269 ILE F CG1 1 
ATOM   1360 C CG2 . ILE A 1 198 ? 155.884 140.762 131.723 1.00 28.98  ? 269 ILE F CG2 1 
ATOM   1361 C CD1 . ILE A 1 198 ? 158.795 140.330 132.314 1.00 28.98  ? 269 ILE F CD1 1 
ATOM   1362 N N   . LEU A 1 199 ? 156.593 144.851 129.842 1.00 31.19  ? 270 LEU F N   1 
ATOM   1363 C CA  . LEU A 1 199 ? 157.207 146.164 129.695 1.00 31.19  ? 270 LEU F CA  1 
ATOM   1364 C C   . LEU A 1 199 ? 157.218 146.880 131.035 1.00 31.19  ? 270 LEU F C   1 
ATOM   1365 O O   . LEU A 1 199 ? 156.143 147.168 131.582 1.00 31.19  ? 270 LEU F O   1 
ATOM   1366 C CB  . LEU A 1 199 ? 156.466 147.004 128.657 1.00 31.19  ? 270 LEU F CB  1 
ATOM   1367 C CG  . LEU A 1 199 ? 157.011 146.963 127.230 1.00 31.19  ? 270 LEU F CG  1 
ATOM   1368 C CD1 . LEU A 1 199 ? 156.740 145.613 126.595 1.00 31.19  ? 270 LEU F CD1 1 
ATOM   1369 C CD2 . LEU A 1 199 ? 156.421 148.090 126.395 1.00 31.19  ? 270 LEU F CD2 1 
ATOM   1370 N N   . PRO A 1 200 ? 158.390 147.164 131.608 1.00 29.49  ? 271 PRO F N   1 
ATOM   1371 C CA  . PRO A 1 200 ? 158.461 148.005 132.811 1.00 29.49  ? 271 PRO F CA  1 
ATOM   1372 C C   . PRO A 1 200 ? 158.236 149.465 132.452 1.00 29.49  ? 271 PRO F C   1 
ATOM   1373 O O   . PRO A 1 200 ? 159.069 150.097 131.797 1.00 29.49  ? 271 PRO F O   1 
ATOM   1374 C CB  . PRO A 1 200 ? 159.888 147.753 133.326 1.00 29.49  ? 271 PRO F CB  1 
ATOM   1375 C CG  . PRO A 1 200 ? 160.374 146.530 132.597 1.00 29.49  ? 271 PRO F CG  1 
ATOM   1376 C CD  . PRO A 1 200 ? 159.693 146.571 131.273 1.00 29.49  ? 271 PRO F CD  1 
ATOM   1377 N N   . VAL A 1 201 ? 157.103 150.005 132.883 1.00 23.86  ? 272 VAL F N   1 
ATOM   1378 C CA  . VAL A 1 201 ? 156.726 151.367 132.566 1.00 23.86  ? 272 VAL F CA  1 
ATOM   1379 C C   . VAL A 1 201 ? 157.036 152.263 133.759 1.00 23.86  ? 272 VAL F C   1 
ATOM   1380 O O   . VAL A 1 201 ? 157.341 151.798 134.854 1.00 23.86  ? 272 VAL F O   1 
ATOM   1381 C CB  . VAL A 1 201 ? 155.237 151.470 132.156 1.00 23.86  ? 272 VAL F CB  1 
ATOM   1382 C CG1 . VAL A 1 201 ? 154.948 150.551 130.980 1.00 23.86  ? 272 VAL F CG1 1 
ATOM   1383 C CG2 . VAL A 1 201 ? 154.338 151.137 133.335 1.00 23.86  ? 272 VAL F CG2 1 
ATOM   1384 N N   . VAL A 1 202 ? 156.976 153.572 133.539 1.00 25.43  ? 273 VAL F N   1 
ATOM   1385 C CA  . VAL A 1 202 ? 157.190 154.551 134.598 1.00 25.43  ? 273 VAL F CA  1 
ATOM   1386 C C   . VAL A 1 202 ? 155.864 154.829 135.291 1.00 25.43  ? 273 VAL F C   1 
ATOM   1387 O O   . VAL A 1 202 ? 154.795 154.826 134.670 1.00 25.43  ? 273 VAL F O   1 
ATOM   1388 C CB  . VAL A 1 202 ? 157.823 155.844 134.042 1.00 25.43  ? 273 VAL F CB  1 
ATOM   1389 C CG1 . VAL A 1 202 ? 159.260 155.587 133.615 1.00 25.43  ? 273 VAL F CG1 1 
ATOM   1390 C CG2 . VAL A 1 202 ? 157.010 156.373 132.875 1.00 25.43  ? 273 VAL F CG2 1 
ATOM   1391 N N   . ALA A 1 203 ? 155.934 155.064 136.604 1.00 24.63  ? 274 ALA F N   1 
ATOM   1392 C CA  . ALA A 1 203 ? 154.720 155.253 137.392 1.00 24.63  ? 274 ALA F CA  1 
ATOM   1393 C C   . ALA A 1 203 ? 154.026 156.567 137.054 1.00 24.63  ? 274 ALA F C   1 
ATOM   1394 O O   . ALA A 1 203 ? 152.791 156.644 137.076 1.00 24.63  ? 274 ALA F O   1 
ATOM   1395 C CB  . ALA A 1 203 ? 155.050 155.190 138.883 1.00 24.63  ? 274 ALA F CB  1 
ATOM   1396 N N   . LYS A 1 204 ? 154.800 157.612 136.749 1.00 30.81  ? 275 LYS F N   1 
ATOM   1397 C CA  . LYS A 1 204 ? 154.215 158.931 136.525 1.00 30.81  ? 275 LYS F CA  1 
ATOM   1398 C C   . LYS A 1 204 ? 153.286 158.937 135.316 1.00 30.81  ? 275 LYS F C   1 
ATOM   1399 O O   . LYS A 1 204 ? 152.222 159.567 135.347 1.00 30.81  ? 275 LYS F O   1 
ATOM   1400 C CB  . LYS A 1 204 ? 155.320 159.974 136.356 1.00 30.81  ? 275 LYS F CB  1 
ATOM   1401 C CG  . LYS A 1 204 ? 156.220 160.128 137.572 1.00 30.81  ? 275 LYS F CG  1 
ATOM   1402 C CD  . LYS A 1 204 ? 157.196 161.280 137.394 1.00 30.81  ? 275 LYS F CD  1 
ATOM   1403 C CE  . LYS A 1 204 ? 158.074 161.078 136.170 1.00 30.81  ? 275 LYS F CE  1 
ATOM   1404 N NZ  . LYS A 1 204 ? 159.022 162.210 135.976 1.00 30.81  ? 275 LYS F NZ  1 
ATOM   1405 N N   . ASP A 1 205 ? 153.676 158.251 134.239 1.00 31.01  ? 276 ASP F N   1 
ATOM   1406 C CA  . ASP A 1 205 ? 152.843 158.223 133.041 1.00 31.01  ? 276 ASP F CA  1 
ATOM   1407 C C   . ASP A 1 205 ? 151.496 157.565 133.314 1.00 31.01  ? 276 ASP F C   1 
ATOM   1408 O O   . ASP A 1 205 ? 150.456 158.049 132.853 1.00 31.01  ? 276 ASP F O   1 
ATOM   1409 C CB  . ASP A 1 205 ? 153.573 157.504 131.907 1.00 31.01  ? 276 ASP F CB  1 
ATOM   1410 C CG  . ASP A 1 205 ? 154.681 158.344 131.303 1.00 31.01  ? 276 ASP F CG  1 
ATOM   1411 O OD1 . ASP A 1 205 ? 154.887 159.484 131.770 1.00 31.01  ? 276 ASP F OD1 1 
ATOM   1412 O OD2 . ASP A 1 205 ? 155.345 157.866 130.360 1.00 31.01  ? 276 ASP F OD2 1 
ATOM   1413 N N   . TRP A 1 206 ? 151.493 156.458 134.061 1.00 24.96  ? 277 TRP F N   1 
ATOM   1414 C CA  . TRP A 1 206 ? 150.231 155.800 134.380 1.00 24.96  ? 277 TRP F CA  1 
ATOM   1415 C C   . TRP A 1 206 ? 149.406 156.612 135.371 1.00 24.96  ? 277 TRP F C   1 
ATOM   1416 O O   . TRP A 1 206 ? 148.173 156.615 135.288 1.00 24.96  ? 277 TRP F O   1 
ATOM   1417 C CB  . TRP A 1 206 ? 150.483 154.396 134.927 1.00 24.96  ? 277 TRP F CB  1 
ATOM   1418 C CG  . TRP A 1 206 ? 149.220 153.626 135.159 1.00 24.96  ? 277 TRP F CG  1 
ATOM   1419 C CD1 . TRP A 1 206 ? 148.529 153.518 136.329 1.00 24.96  ? 277 TRP F CD1 1 
ATOM   1420 C CD2 . TRP A 1 206 ? 148.489 152.866 134.189 1.00 24.96  ? 277 TRP F CD2 1 
ATOM   1421 N NE1 . TRP A 1 206 ? 147.416 152.732 136.151 1.00 24.96  ? 277 TRP F NE1 1 
ATOM   1422 C CE2 . TRP A 1 206 ? 147.368 152.320 134.845 1.00 24.96  ? 277 TRP F CE2 1 
ATOM   1423 C CE3 . TRP A 1 206 ? 148.674 152.593 132.830 1.00 24.96  ? 277 TRP F CE3 1 
ATOM   1424 C CZ2 . TRP A 1 206 ? 146.438 151.517 134.191 1.00 24.96  ? 277 TRP F CZ2 1 
ATOM   1425 C CZ3 . TRP A 1 206 ? 147.749 151.795 132.182 1.00 24.96  ? 277 TRP F CZ3 1 
ATOM   1426 C CH2 . TRP A 1 206 ? 146.645 151.267 132.863 1.00 24.96  ? 277 TRP F CH2 1 
ATOM   1427 N N   . ILE A 1 207 ? 150.060 157.293 136.315 1.00 30.96  ? 278 ILE F N   1 
ATOM   1428 C CA  . ILE A 1 207 ? 149.330 158.145 137.251 1.00 30.96  ? 278 ILE F CA  1 
ATOM   1429 C C   . ILE A 1 207 ? 148.635 159.277 136.506 1.00 30.96  ? 278 ILE F C   1 
ATOM   1430 O O   . ILE A 1 207 ? 147.459 159.574 136.753 1.00 30.96  ? 278 ILE F O   1 
ATOM   1431 C CB  . ILE A 1 207 ? 150.276 158.677 138.344 1.00 30.96  ? 278 ILE F CB  1 
ATOM   1432 C CG1 . ILE A 1 207 ? 150.690 157.547 139.289 1.00 30.96  ? 278 ILE F CG1 1 
ATOM   1433 C CG2 . ILE A 1 207 ? 149.617 159.808 139.121 1.00 30.96  ? 278 ILE F CG2 1 
ATOM   1434 C CD1 . ILE A 1 207 ? 151.632 157.985 140.389 1.00 30.96  ? 278 ILE F CD1 1 
ATOM   1435 N N   . GLU A 1 208 ? 149.345 159.921 135.578 1.00 30.02  ? 279 GLU F N   1 
ATOM   1436 C CA  . GLU A 1 208 ? 148.716 160.948 134.755 1.00 30.02  ? 279 GLU F CA  1 
ATOM   1437 C C   . GLU A 1 208 ? 147.761 160.341 133.736 1.00 30.02  ? 279 GLU F C   1 
ATOM   1438 O O   . GLU A 1 208 ? 146.772 160.979 133.357 1.00 30.02  ? 279 GLU F O   1 
ATOM   1439 C CB  . GLU A 1 208 ? 149.784 161.786 134.051 1.00 30.02  ? 279 GLU F CB  1 
ATOM   1440 C CG  . GLU A 1 208 ? 150.714 162.526 134.998 1.00 30.02  ? 279 GLU F CG  1 
ATOM   1441 C CD  . GLU A 1 208 ? 151.770 163.331 134.267 1.00 30.02  ? 279 GLU F CD  1 
ATOM   1442 O OE1 . GLU A 1 208 ? 151.812 163.266 133.020 1.00 30.02  ? 279 GLU F OE1 1 
ATOM   1443 O OE2 . GLU A 1 208 ? 152.557 164.031 134.938 1.00 30.02  ? 279 GLU F OE2 1 
ATOM   1444 N N   . GLY A 1 209 ? 148.035 159.119 133.286 1.00 31.26  ? 280 GLY F N   1 
ATOM   1445 C CA  . GLY A 1 209 ? 147.174 158.439 132.338 1.00 31.26  ? 280 GLY F CA  1 
ATOM   1446 C C   . GLY A 1 209 ? 147.712 158.463 130.923 1.00 31.26  ? 280 GLY F C   1 
ATOM   1447 O O   . GLY A 1 209 ? 147.556 159.458 130.210 1.00 31.26  ? 280 GLY F O   1 
ATOM   1448 N N   . TYR A 1 210 ? 148.336 157.361 130.502 1.00 33.31  ? 281 TYR F N   1 
ATOM   1449 C CA  . TYR A 1 210 ? 148.922 157.262 129.164 1.00 33.31  ? 281 TYR F CA  1 
ATOM   1450 C C   . TYR A 1 210 ? 148.771 155.813 128.706 1.00 33.31  ? 281 TYR F C   1 
ATOM   1451 O O   . TYR A 1 210 ? 149.588 154.960 129.063 1.00 33.31  ? 281 TYR F O   1 
ATOM   1452 C CB  . TYR A 1 210 ? 150.382 157.697 129.167 1.00 33.31  ? 281 TYR F CB  1 
ATOM   1453 C CG  . TYR A 1 210 ? 150.588 159.196 129.213 1.00 33.31  ? 281 TYR F CG  1 
ATOM   1454 C CD1 . TYR A 1 210 ? 149.878 160.041 128.372 1.00 33.31  ? 281 TYR F CD1 1 
ATOM   1455 C CD2 . TYR A 1 210 ? 151.495 159.764 130.098 1.00 33.31  ? 281 TYR F CD2 1 
ATOM   1456 C CE1 . TYR A 1 210 ? 150.063 161.411 128.411 1.00 33.31  ? 281 TYR F CE1 1 
ATOM   1457 C CE2 . TYR A 1 210 ? 151.687 161.132 130.145 1.00 33.31  ? 281 TYR F CE2 1 
ATOM   1458 C CZ  . TYR A 1 210 ? 150.969 161.950 129.299 1.00 33.31  ? 281 TYR F CZ  1 
ATOM   1459 O OH  . TYR A 1 210 ? 151.157 163.313 129.342 1.00 33.31  ? 281 TYR F OH  1 
ATOM   1460 N N   . GLY A 1 211 ? 147.730 155.548 127.921 1.00 35.70  ? 282 GLY F N   1 
ATOM   1461 C CA  . GLY A 1 211 ? 147.496 154.198 127.447 1.00 35.70  ? 282 GLY F CA  1 
ATOM   1462 C C   . GLY A 1 211 ? 148.467 153.797 126.352 1.00 35.70  ? 282 GLY F C   1 
ATOM   1463 O O   . GLY A 1 211 ? 148.909 154.614 125.543 1.00 35.70  ? 282 GLY F O   1 
ATOM   1464 N N   . TYR A 1 212 ? 148.800 152.512 126.332 1.00 37.29  ? 283 TYR F N   1 
ATOM   1465 C CA  . TYR A 1 212 ? 149.712 151.931 125.353 1.00 37.29  ? 283 TYR F CA  1 
ATOM   1466 C C   . TYR A 1 212 ? 148.963 150.892 124.522 1.00 37.29  ? 283 TYR F C   1 
ATOM   1467 O O   . TYR A 1 212 ? 147.779 150.627 124.741 1.00 37.29  ? 283 TYR F O   1 
ATOM   1468 C CB  . TYR A 1 212 ? 150.931 151.311 126.043 1.00 37.29  ? 283 TYR F CB  1 
ATOM   1469 C CG  . TYR A 1 212 ? 151.715 152.278 126.905 1.00 37.29  ? 283 TYR F CG  1 
ATOM   1470 C CD1 . TYR A 1 212 ? 151.772 153.630 126.593 1.00 37.29  ? 283 TYR F CD1 1 
ATOM   1471 C CD2 . TYR A 1 212 ? 152.397 151.838 128.031 1.00 37.29  ? 283 TYR F CD2 1 
ATOM   1472 C CE1 . TYR A 1 212 ? 152.486 154.516 127.378 1.00 37.29  ? 283 TYR F CE1 1 
ATOM   1473 C CE2 . TYR A 1 212 ? 153.113 152.717 128.823 1.00 37.29  ? 283 TYR F CE2 1 
ATOM   1474 C CZ  . TYR A 1 212 ? 153.154 154.054 128.492 1.00 37.29  ? 283 TYR F CZ  1 
ATOM   1475 O OH  . TYR A 1 212 ? 153.866 154.932 129.277 1.00 37.29  ? 283 TYR F OH  1 
ATOM   1476 N N   . GLN A 1 213 ? 149.660 150.299 123.553 1.00 34.97  ? 284 GLN F N   1 
ATOM   1477 C CA  . GLN A 1 213 ? 149.060 149.278 122.706 1.00 34.97  ? 284 GLN F CA  1 
ATOM   1478 C C   . GLN A 1 213 ? 150.028 148.120 122.519 1.00 34.97  ? 284 GLN F C   1 
ATOM   1479 O O   . GLN A 1 213 ? 151.231 148.330 122.350 1.00 34.97  ? 284 GLN F O   1 
ATOM   1480 C CB  . GLN A 1 213 ? 148.663 149.847 121.336 1.00 34.97  ? 284 GLN F CB  1 
ATOM   1481 C CG  . GLN A 1 213 ? 147.567 150.899 121.388 1.00 34.97  ? 284 GLN F CG  1 
ATOM   1482 C CD  . GLN A 1 213 ? 147.206 151.433 120.015 1.00 34.97  ? 284 GLN F CD  1 
ATOM   1483 O OE1 . GLN A 1 213 ? 147.865 151.123 119.023 1.00 34.97  ? 284 GLN F OE1 1 
ATOM   1484 N NE2 . GLN A 1 213 ? 146.153 152.240 119.952 1.00 34.97  ? 284 GLN F NE2 1 
ATOM   1485 N N   . CYS A 1 214 ? 149.493 146.901 122.538 1.00 29.51  ? 285 CYS F N   1 
ATOM   1486 C CA  . CYS A 1 214 ? 150.254 145.689 122.260 1.00 29.51  ? 285 CYS F CA  1 
ATOM   1487 C C   . CYS A 1 214 ? 149.711 145.053 120.989 1.00 29.51  ? 285 CYS F C   1 
ATOM   1488 O O   . CYS A 1 214 ? 148.501 144.827 120.876 1.00 29.51  ? 285 CYS F O   1 
ATOM   1489 C CB  . CYS A 1 214 ? 150.167 144.696 123.424 1.00 29.51  ? 285 CYS F CB  1 
ATOM   1490 S SG  . CYS A 1 214 ? 150.850 143.059 123.053 1.00 29.51  ? 285 CYS F SG  1 
ATOM   1491 N N   . ILE A 1 215 ? 150.599 144.757 120.042 1.00 28.50  ? 286 ILE F N   1 
ATOM   1492 C CA  . ILE A 1 215 ? 150.223 144.170 118.762 1.00 28.50  ? 286 ILE F CA  1 
ATOM   1493 C C   . ILE A 1 215 ? 151.009 142.879 118.586 1.00 28.50  ? 286 ILE F C   1 
ATOM   1494 O O   . ILE A 1 215 ? 152.229 142.860 118.775 1.00 28.50  ? 286 ILE F O   1 
ATOM   1495 C CB  . ILE A 1 215 ? 150.494 145.135 117.593 1.00 28.50  ? 286 ILE F CB  1 
ATOM   1496 C CG1 . ILE A 1 215 ? 150.000 146.543 117.929 1.00 28.50  ? 286 ILE F CG1 1 
ATOM   1497 C CG2 . ILE A 1 215 ? 149.822 144.636 116.326 1.00 28.50  ? 286 ILE F CG2 1 
ATOM   1498 C CD1 . ILE A 1 215 ? 150.352 147.576 116.881 1.00 28.50  ? 286 ILE F CD1 1 
ATOM   1499 N N   . VAL A 1 216 ? 150.311 141.805 118.233 1.00 28.60  ? 287 VAL F N   1 
ATOM   1500 C CA  . VAL A 1 216 ? 150.926 140.510 117.965 1.00 28.60  ? 287 VAL F CA  1 
ATOM   1501 C C   . VAL A 1 216 ? 150.701 140.173 116.498 1.00 28.60  ? 287 VAL F C   1 
ATOM   1502 O O   . VAL A 1 216 ? 149.578 140.297 115.988 1.00 28.60  ? 287 VAL F O   1 
ATOM   1503 C CB  . VAL A 1 216 ? 150.370 139.413 118.891 1.00 28.60  ? 287 VAL F CB  1 
ATOM   1504 C CG1 . VAL A 1 216 ? 148.858 139.474 118.945 1.00 28.60  ? 287 VAL F CG1 1 
ATOM   1505 C CG2 . VAL A 1 216 ? 150.838 138.037 118.435 1.00 28.60  ? 287 VAL F CG2 1 
ATOM   1506 N N   . ASP A 1 217 ? 151.775 139.770 115.818 1.00 34.88  ? 288 ASP F N   1 
ATOM   1507 C CA  . ASP A 1 217 ? 151.756 139.494 114.389 1.00 34.88  ? 288 ASP F CA  1 
ATOM   1508 C C   . ASP A 1 217 ? 152.242 138.074 114.136 1.00 34.88  ? 288 ASP F C   1 
ATOM   1509 O O   . ASP A 1 217 ? 153.293 137.668 114.650 1.00 34.88  ? 288 ASP F O   1 
ATOM   1510 C CB  . ASP A 1 217 ? 152.626 140.498 113.626 1.00 34.88  ? 288 ASP F CB  1 
ATOM   1511 C CG  . ASP A 1 217 ? 152.442 140.409 112.123 1.00 34.88  ? 288 ASP F CG  1 
ATOM   1512 O OD1 . ASP A 1 217 ? 151.538 139.673 111.673 1.00 34.88  ? 288 ASP F OD1 1 
ATOM   1513 O OD2 . ASP A 1 217 ? 153.202 141.076 111.390 1.00 34.88  ? 288 ASP F OD2 1 
ATOM   1514 N N   . HIS A 1 218 ? 151.462 137.326 113.339 1.00 39.62  ? 289 HIS F N   1 
ATOM   1515 C CA  . HIS A 1 218 ? 151.634 135.961 112.869 1.00 39.62  ? 289 HIS F CA  1 
ATOM   1516 C C   . HIS A 1 218 ? 151.919 135.960 111.367 1.00 39.62  ? 289 HIS F C   1 
ATOM   1517 O O   . HIS A 1 218 ? 151.444 136.843 110.646 1.00 39.62  ? 289 HIS F O   1 
ATOM   1518 C CB  . HIS A 1 218 ? 150.370 135.137 113.154 1.00 39.62  ? 289 HIS F CB  1 
ATOM   1519 C CG  . HIS A 1 218 ? 150.607 133.660 113.228 1.00 39.62  ? 289 HIS F CG  1 
ATOM   1520 N ND1 . HIS A 1 218 ? 150.412 132.819 112.153 1.00 39.62  ? 289 HIS F ND1 1 
ATOM   1521 C CD2 . HIS A 1 218 ? 151.022 132.874 114.249 1.00 39.62  ? 289 HIS F CD2 1 
ATOM   1522 C CE1 . HIS A 1 218 ? 150.700 131.580 112.509 1.00 39.62  ? 289 HIS F CE1 1 
ATOM   1523 N NE2 . HIS A 1 218 ? 151.073 131.586 113.776 1.00 39.62  ? 289 HIS F NE2 1 
ATOM   1524 N N   . PRO A 1 219 ? 152.695 134.994 110.863 1.00 39.47  ? 290 PRO F N   1 
ATOM   1525 C CA  . PRO A 1 219 ? 153.001 134.986 109.420 1.00 39.47  ? 290 PRO F CA  1 
ATOM   1526 C C   . PRO A 1 219 ? 151.776 134.928 108.523 1.00 39.47  ? 290 PRO F C   1 
ATOM   1527 O O   . PRO A 1 219 ? 151.768 135.574 107.469 1.00 39.47  ? 290 PRO F O   1 
ATOM   1528 C CB  . PRO A 1 219 ? 153.880 133.737 109.252 1.00 39.47  ? 290 PRO F CB  1 
ATOM   1529 C CG  . PRO A 1 219 ? 153.675 132.933 110.496 1.00 39.47  ? 290 PRO F CG  1 
ATOM   1530 C CD  . PRO A 1 219 ? 153.427 133.935 111.575 1.00 39.47  ? 290 PRO F CD  1 
ATOM   1531 N N   . ASP A 1 220 ? 150.738 134.181 108.898 1.00 33.35  ? 291 ASP F N   1 
ATOM   1532 C CA  . ASP A 1 220 ? 149.522 134.075 108.090 1.00 33.35  ? 291 ASP F CA  1 
ATOM   1533 C C   . ASP A 1 220 ? 148.337 134.425 108.986 1.00 33.35  ? 291 ASP F C   1 
ATOM   1534 O O   . ASP A 1 220 ? 147.713 133.546 109.583 1.00 33.35  ? 291 ASP F O   1 
ATOM   1535 C CB  . ASP A 1 220 ? 149.382 132.680 107.462 1.00 33.35  ? 291 ASP F CB  1 
ATOM   1536 C CG  . ASP A 1 220 ? 149.726 131.562 108.428 1.00 33.35  ? 291 ASP F CG  1 
ATOM   1537 O OD1 . ASP A 1 220 ? 150.120 131.870 109.570 1.00 33.35  ? 291 ASP F OD1 1 
ATOM   1538 O OD2 . ASP A 1 220 ? 149.606 130.377 108.046 1.00 33.35  ? 291 ASP F OD2 1 
ATOM   1539 N N   . PHE A 1 221 ? 148.027 135.713 109.079 1.00 24.72  ? 292 PHE F N   1 
ATOM   1540 C CA  . PHE A 1 221 ? 146.887 136.186 109.847 1.00 24.72  ? 292 PHE F CA  1 
ATOM   1541 C C   . PHE A 1 221 ? 146.152 137.242 109.038 1.00 24.72  ? 292 PHE F C   1 
ATOM   1542 O O   . PHE A 1 221 ? 146.758 137.912 108.194 1.00 24.72  ? 292 PHE F O   1 
ATOM   1543 C CB  . PHE A 1 221 ? 147.318 136.774 111.200 1.00 24.72  ? 292 PHE F CB  1 
ATOM   1544 C CG  . PHE A 1 221 ? 146.488 136.303 112.360 1.00 24.72  ? 292 PHE F CG  1 
ATOM   1545 C CD1 . PHE A 1 221 ? 146.518 134.976 112.751 1.00 24.72  ? 292 PHE F CD1 1 
ATOM   1546 C CD2 . PHE A 1 221 ? 145.702 137.191 113.076 1.00 24.72  ? 292 PHE F CD2 1 
ATOM   1547 C CE1 . PHE A 1 221 ? 145.770 134.542 113.825 1.00 24.72  ? 292 PHE F CE1 1 
ATOM   1548 C CE2 . PHE A 1 221 ? 144.946 136.762 114.149 1.00 24.72  ? 292 PHE F CE2 1 
ATOM   1549 C CZ  . PHE A 1 221 ? 144.979 135.435 114.525 1.00 24.72  ? 292 PHE F CZ  1 
ATOM   1550 N N   . PRO A 1 222 ? 144.845 137.401 109.262 1.00 19.40  ? 293 PRO F N   1 
ATOM   1551 C CA  . PRO A 1 222 ? 144.123 138.480 108.560 1.00 19.40  ? 293 PRO F CA  1 
ATOM   1552 C C   . PRO A 1 222 ? 144.639 139.863 108.921 1.00 19.40  ? 293 PRO F C   1 
ATOM   1553 O O   . PRO A 1 222 ? 145.065 140.618 108.036 1.00 19.40  ? 293 PRO F O   1 
ATOM   1554 C CB  . PRO A 1 222 ? 142.668 138.269 109.003 1.00 19.40  ? 293 PRO F CB  1 
ATOM   1555 C CG  . PRO A 1 222 ? 142.600 136.847 109.447 1.00 19.40  ? 293 PRO F CG  1 
ATOM   1556 C CD  . PRO A 1 222 ? 143.940 136.536 110.036 1.00 19.40  ? 293 PRO F CD  1 
ATOM   1557 N N   . LYS A 1 223 ? 144.613 140.216 110.206 1.00 19.75  ? 294 LYS F N   1 
ATOM   1558 C CA  . LYS A 1 223 ? 145.195 141.446 110.717 1.00 19.75  ? 294 LYS F CA  1 
ATOM   1559 C C   . LYS A 1 223 ? 145.884 141.125 112.036 1.00 19.75  ? 294 LYS F C   1 
ATOM   1560 O O   . LYS A 1 223 ? 145.394 140.277 112.798 1.00 19.75  ? 294 LYS F O   1 
ATOM   1561 C CB  . LYS A 1 223 ? 144.140 142.540 110.933 1.00 19.75  ? 294 LYS F CB  1 
ATOM   1562 C CG  . LYS A 1 223 ? 143.397 142.950 109.673 1.00 19.75  ? 294 LYS F CG  1 
ATOM   1563 C CD  . LYS A 1 223 ? 142.331 143.990 109.978 1.00 19.75  ? 294 LYS F CD  1 
ATOM   1564 C CE  . LYS A 1 223 ? 141.342 143.477 111.015 1.00 19.75  ? 294 LYS F CE  1 
ATOM   1565 N NZ  . LYS A 1 223 ? 140.305 144.490 111.366 1.00 19.75  ? 294 LYS F NZ  1 
ATOM   1566 N N   . PRO A 1 224 ? 147.012 141.770 112.331 1.00 24.13  ? 295 PRO F N   1 
ATOM   1567 C CA  . PRO A 1 224 ? 147.660 141.553 113.630 1.00 24.13  ? 295 PRO F CA  1 
ATOM   1568 C C   . PRO A 1 224 ? 146.747 141.987 114.765 1.00 24.13  ? 295 PRO F C   1 
ATOM   1569 O O   . PRO A 1 224 ? 146.035 142.988 114.665 1.00 24.13  ? 295 PRO F O   1 
ATOM   1570 C CB  . PRO A 1 224 ? 148.920 142.422 113.551 1.00 24.13  ? 295 PRO F CB  1 
ATOM   1571 C CG  . PRO A 1 224 ? 148.614 143.444 112.506 1.00 24.13  ? 295 PRO F CG  1 
ATOM   1572 C CD  . PRO A 1 224 ? 147.735 142.753 111.508 1.00 24.13  ? 295 PRO F CD  1 
ATOM   1573 N N   . ILE A 1 225 ? 146.773 141.226 115.855 1.00 24.45  ? 296 ILE F N   1 
ATOM   1574 C CA  . ILE A 1 225 ? 145.843 141.463 116.955 1.00 24.45  ? 296 ILE F CA  1 
ATOM   1575 C C   . ILE A 1 225 ? 146.389 142.589 117.822 1.00 24.45  ? 296 ILE F C   1 
ATOM   1576 O O   . ILE A 1 225 ? 147.518 142.513 118.316 1.00 24.45  ? 296 ILE F O   1 
ATOM   1577 C CB  . ILE A 1 225 ? 145.615 140.187 117.777 1.00 24.45  ? 296 ILE F CB  1 
ATOM   1578 C CG1 . ILE A 1 225 ? 145.045 139.076 116.894 1.00 24.45  ? 296 ILE F CG1 1 
ATOM   1579 C CG2 . ILE A 1 225 ? 144.691 140.466 118.952 1.00 24.45  ? 296 ILE F CG2 1 
ATOM   1580 C CD1 . ILE A 1 225 ? 144.773 137.787 117.639 1.00 24.45  ? 296 ILE F CD1 1 
ATOM   1581 N N   . VAL A 1 226 ? 145.588 143.635 118.011 1.00 26.05  ? 297 VAL F N   1 
ATOM   1582 C CA  . VAL A 1 226 ? 145.995 144.826 118.746 1.00 26.05  ? 297 VAL F CA  1 
ATOM   1583 C C   . VAL A 1 226 ? 145.059 145.010 119.932 1.00 26.05  ? 297 VAL F C   1 
ATOM   1584 O O   . VAL A 1 226 ? 143.834 144.908 119.789 1.00 26.05  ? 297 VAL F O   1 
ATOM   1585 C CB  . VAL A 1 226 ? 145.999 146.076 117.844 1.00 26.05  ? 297 VAL F CB  1 
ATOM   1586 C CG1 . VAL A 1 226 ? 144.683 146.204 117.087 1.00 26.05  ? 297 VAL F CG1 1 
ATOM   1587 C CG2 . VAL A 1 226 ? 146.276 147.329 118.664 1.00 26.05  ? 297 VAL F CG2 1 
ATOM   1588 N N   . ARG A 1 227 ? 145.638 145.260 121.104 1.00 26.17  ? 298 ARG F N   1 
ATOM   1589 C CA  . ARG A 1 227 ? 144.879 145.519 122.319 1.00 26.17  ? 298 ARG F CA  1 
ATOM   1590 C C   . ARG A 1 227 ? 145.446 146.748 123.015 1.00 26.17  ? 298 ARG F C   1 
ATOM   1591 O O   . ARG A 1 227 ? 146.665 146.881 123.164 1.00 26.17  ? 298 ARG F O   1 
ATOM   1592 C CB  . ARG A 1 227 ? 144.907 144.312 123.265 1.00 26.17  ? 298 ARG F CB  1 
ATOM   1593 C CG  . ARG A 1 227 ? 143.949 144.422 124.439 1.00 26.17  ? 298 ARG F CG  1 
ATOM   1594 C CD  . ARG A 1 227 ? 143.802 143.092 125.158 1.00 26.17  ? 298 ARG F CD  1 
ATOM   1595 N NE  . ARG A 1 227 ? 143.339 142.039 124.262 1.00 26.17  ? 298 ARG F NE  1 
ATOM   1596 C CZ  . ARG A 1 227 ? 142.063 141.771 124.017 1.00 26.17  ? 298 ARG F CZ  1 
ATOM   1597 N NH1 . ARG A 1 227 ? 141.090 142.460 124.589 1.00 26.17  ? 298 ARG F NH1 1 
ATOM   1598 N NH2 . ARG A 1 227 ? 141.757 140.785 123.178 1.00 26.17  ? 298 ARG F NH2 1 
ATOM   1599 N N   . SER A 1 228 ? 144.558 147.636 123.451 1.00 29.99  ? 299 SER F N   1 
ATOM   1600 C CA  . SER A 1 228 ? 144.940 148.914 124.033 1.00 29.99  ? 299 SER F CA  1 
ATOM   1601 C C   . SER A 1 228 ? 144.680 148.913 125.534 1.00 29.99  ? 299 SER F C   1 
ATOM   1602 O O   . SER A 1 228 ? 143.690 148.341 126.003 1.00 29.99  ? 299 SER F O   1 
ATOM   1603 C CB  . SER A 1 228 ? 144.174 150.065 123.375 1.00 29.99  ? 299 SER F CB  1 
ATOM   1604 O OG  . SER A 1 228 ? 144.408 150.100 121.978 1.00 29.99  ? 299 SER F OG  1 
ATOM   1605 N N   . ILE A 1 229 ? 145.574 149.556 126.281 1.00 31.19  ? 300 ILE F N   1 
ATOM   1606 C CA  . ILE A 1 229 ? 145.468 149.676 127.729 1.00 31.19  ? 300 ILE F CA  1 
ATOM   1607 C C   . ILE A 1 229 ? 145.419 151.155 128.088 1.00 31.19  ? 300 ILE F C   1 
ATOM   1608 O O   . ILE A 1 229 ? 146.254 151.942 127.626 1.00 31.19  ? 300 ILE F O   1 
ATOM   1609 C CB  . ILE A 1 229 ? 146.634 148.969 128.449 1.00 31.19  ? 300 ILE F CB  1 
ATOM   1610 C CG1 . ILE A 1 229 ? 146.589 149.248 129.953 1.00 31.19  ? 300 ILE F CG1 1 
ATOM   1611 C CG2 . ILE A 1 229 ? 147.977 149.368 127.844 1.00 31.19  ? 300 ILE F CG2 1 
ATOM   1612 C CD1 . ILE A 1 229 ? 145.352 148.705 130.638 1.00 31.19  ? 300 ILE F CD1 1 
ATOM   1613 N N   . THR A 1 230 ? 144.430 151.531 128.896 1.00 30.88  ? 301 THR F N   1 
ATOM   1614 C CA  . THR A 1 230 ? 144.268 152.907 129.341 1.00 30.88  ? 301 THR F CA  1 
ATOM   1615 C C   . THR A 1 230 ? 143.692 152.893 130.749 1.00 30.88  ? 301 THR F C   1 
ATOM   1616 O O   . THR A 1 230 ? 142.865 152.039 131.077 1.00 30.88  ? 301 THR F O   1 
ATOM   1617 C CB  . THR A 1 230 ? 143.354 153.700 128.397 1.00 30.88  ? 301 THR F CB  1 
ATOM   1618 O OG1 . THR A 1 230 ? 143.808 153.545 127.046 1.00 30.88  ? 301 THR F OG1 1 
ATOM   1619 C CG2 . THR A 1 230 ? 143.363 155.180 128.753 1.00 30.88  ? 301 THR F CG2 1 
ATOM   1620 N N   . LYS A 1 231 ? 144.142 153.835 131.577 1.00 23.03  ? 302 LYS F N   1 
ATOM   1621 C CA  . LYS A 1 231 ? 143.638 153.932 132.940 1.00 23.03  ? 302 LYS F CA  1 
ATOM   1622 C C   . LYS A 1 231 ? 142.147 154.247 132.933 1.00 23.03  ? 302 LYS F C   1 
ATOM   1623 O O   . LYS A 1 231 ? 141.670 155.062 132.139 1.00 23.03  ? 302 LYS F O   1 
ATOM   1624 C CB  . LYS A 1 231 ? 144.405 155.006 133.713 1.00 23.03  ? 302 LYS F CB  1 
ATOM   1625 C CG  . LYS A 1 231 ? 144.018 155.116 135.180 1.00 23.03  ? 302 LYS F CG  1 
ATOM   1626 C CD  . LYS A 1 231 ? 144.845 156.174 135.892 1.00 23.03  ? 302 LYS F CD  1 
ATOM   1627 C CE  . LYS A 1 231 ? 144.641 157.547 135.271 1.00 23.03  ? 302 LYS F CE  1 
ATOM   1628 N NZ  . LYS A 1 231 ? 143.220 157.983 135.343 1.00 23.03  ? 302 LYS F NZ  1 
ATOM   1629 N N   . THR A 1 232 ? 141.412 153.592 133.822 1.00 20.49  ? 303 THR F N   1 
ATOM   1630 C CA  . THR A 1 232 ? 139.963 153.753 133.871 1.00 20.49  ? 303 THR F CA  1 
ATOM   1631 C C   . THR A 1 232 ? 139.602 155.149 134.363 1.00 20.49  ? 303 THR F C   1 
ATOM   1632 O O   . THR A 1 232 ? 140.043 155.546 135.450 1.00 20.49  ? 303 THR F O   1 
ATOM   1633 C CB  . THR A 1 232 ? 139.342 152.697 134.781 1.00 20.49  ? 303 THR F CB  1 
ATOM   1634 O OG1 . THR A 1 232 ? 139.879 152.827 136.103 1.00 20.49  ? 303 THR F OG1 1 
ATOM   1635 C CG2 . THR A 1 232 ? 139.639 151.300 134.255 1.00 20.49  ? 303 THR F CG2 1 
ATOM   1636 N N   . PRO A 1 233 ? 138.817 155.918 133.615 1.00 22.36  ? 304 PRO F N   1 
ATOM   1637 C CA  . PRO A 1 233 ? 138.431 157.254 134.078 1.00 22.36  ? 304 PRO F CA  1 
ATOM   1638 C C   . PRO A 1 233 ? 137.384 157.184 135.179 1.00 22.36  ? 304 PRO F C   1 
ATOM   1639 O O   . PRO A 1 233 ? 136.716 156.168 135.384 1.00 22.36  ? 304 PRO F O   1 
ATOM   1640 C CB  . PRO A 1 233 ? 137.868 157.916 132.818 1.00 22.36  ? 304 PRO F CB  1 
ATOM   1641 C CG  . PRO A 1 233 ? 137.348 156.774 132.011 1.00 22.36  ? 304 PRO F CG  1 
ATOM   1642 C CD  . PRO A 1 233 ? 138.279 155.619 132.276 1.00 22.36  ? 304 PRO F CD  1 
ATOM   1643 N N   . GLY A 1 234 ? 137.251 158.289 135.890 1.00 22.38  ? 305 GLY F N   1 
ATOM   1644 C CA  . GLY A 1 234 ? 136.286 158.415 136.966 1.00 22.38  ? 305 GLY F CA  1 
ATOM   1645 C C   . GLY A 1 234 ? 136.907 159.071 138.184 1.00 22.38  ? 305 GLY F C   1 
ATOM   1646 O O   . GLY A 1 234 ? 138.124 159.092 138.367 1.00 22.38  ? 305 GLY F O   1 
ATOM   1647 N N   . GLN A 1 235 ? 136.045 159.623 139.034 1.00 19.67  ? 306 GLN F N   1 
ATOM   1648 C CA  . GLN A 1 235 ? 136.506 160.270 140.255 1.00 19.67  ? 306 GLN F CA  1 
ATOM   1649 C C   . GLN A 1 235 ? 137.061 159.239 141.229 1.00 19.67  ? 306 GLN F C   1 
ATOM   1650 O O   . GLN A 1 235 ? 136.508 158.147 141.388 1.00 19.67  ? 306 GLN F O   1 
ATOM   1651 C CB  . GLN A 1 235 ? 135.363 161.050 140.905 1.00 19.67  ? 306 GLN F CB  1 
ATOM   1652 C CG  . GLN A 1 235 ? 135.760 161.816 142.156 1.00 19.67  ? 306 GLN F CG  1 
ATOM   1653 C CD  . GLN A 1 235 ? 134.601 162.579 142.765 1.00 19.67  ? 306 GLN F CD  1 
ATOM   1654 O OE1 . GLN A 1 235 ? 133.489 162.568 142.237 1.00 19.67  ? 306 GLN F OE1 1 
ATOM   1655 N NE2 . GLN A 1 235 ? 134.855 163.248 143.884 1.00 19.67  ? 306 GLN F NE2 1 
ATOM   1656 N N   . ARG A 1 236 ? 138.164 159.591 141.884 1.00 15.96  ? 307 ARG F N   1 
ATOM   1657 C CA  . ARG A 1 236 ? 138.810 158.709 142.846 1.00 15.96  ? 307 ARG F CA  1 
ATOM   1658 C C   . ARG A 1 236 ? 138.328 159.038 144.253 1.00 15.96  ? 307 ARG F C   1 
ATOM   1659 O O   . ARG A 1 236 ? 138.361 160.200 144.672 1.00 15.96  ? 307 ARG F O   1 
ATOM   1660 C CB  . ARG A 1 236 ? 140.332 158.834 142.763 1.00 15.96  ? 307 ARG F CB  1 
ATOM   1661 C CG  . ARG A 1 236 ? 140.996 157.870 141.787 1.00 15.96  ? 307 ARG F CG  1 
ATOM   1662 C CD  . ARG A 1 236 ? 140.585 158.138 140.348 1.00 15.96  ? 307 ARG F CD  1 
ATOM   1663 N NE  . ARG A 1 236 ? 141.184 157.184 139.422 1.00 15.96  ? 307 ARG F NE  1 
ATOM   1664 C CZ  . ARG A 1 236 ? 140.966 157.170 138.115 1.00 15.96  ? 307 ARG F CZ  1 
ATOM   1665 N NH1 . ARG A 1 236 ? 140.164 158.050 137.538 1.00 15.96  ? 307 ARG F NH1 1 
ATOM   1666 N NH2 . ARG A 1 236 ? 141.568 156.250 137.366 1.00 15.96  ? 307 ARG F NH2 1 
ATOM   1667 N N   . SER A 1 237 ? 137.882 158.015 144.975 1.00 17.54  ? 308 SER F N   1 
ATOM   1668 C CA  . SER A 1 237 ? 137.376 158.160 146.333 1.00 17.54  ? 308 SER F CA  1 
ATOM   1669 C C   . SER A 1 237 ? 138.314 157.453 147.300 1.00 17.54  ? 308 SER F C   1 
ATOM   1670 O O   . SER A 1 237 ? 138.732 156.318 147.047 1.00 17.54  ? 308 SER F O   1 
ATOM   1671 C CB  . SER A 1 237 ? 135.961 157.590 146.454 1.00 17.54  ? 308 SER F CB  1 
ATOM   1672 O OG  . SER A 1 237 ? 135.471 157.717 147.777 1.00 17.54  ? 308 SER F OG  1 
ATOM   1673 N N   . ALA A 1 238 ? 138.643 158.125 148.397 1.00 20.78  ? 309 ALA F N   1 
ATOM   1674 C CA  . ALA A 1 238 ? 139.543 157.544 149.386 1.00 20.78  ? 309 ALA F CA  1 
ATOM   1675 C C   . ALA A 1 238 ? 138.890 156.328 150.033 1.00 20.78  ? 309 ALA F C   1 
ATOM   1676 O O   . ALA A 1 238 ? 137.762 156.427 150.530 1.00 20.78  ? 309 ALA F O   1 
ATOM   1677 C CB  . ALA A 1 238 ? 139.910 158.577 150.448 1.00 20.78  ? 309 ALA F CB  1 
ATOM   1678 N N   . PRO A 1 239 ? 139.552 155.173 150.042 1.00 19.92  ? 310 PRO F N   1 
ATOM   1679 C CA  . PRO A 1 239 ? 138.943 153.979 150.636 1.00 19.92  ? 310 PRO F CA  1 
ATOM   1680 C C   . PRO A 1 239 ? 138.768 154.111 152.140 1.00 19.92  ? 310 PRO F C   1 
ATOM   1681 O O   . PRO A 1 239 ? 139.545 154.776 152.829 1.00 19.92  ? 310 PRO F O   1 
ATOM   1682 C CB  . PRO A 1 239 ? 139.939 152.865 150.292 1.00 19.92  ? 310 PRO F CB  1 
ATOM   1683 C CG  . PRO A 1 239 ? 141.239 153.572 150.095 1.00 19.92  ? 310 PRO F CG  1 
ATOM   1684 C CD  . PRO A 1 239 ? 140.888 154.898 149.487 1.00 19.92  ? 310 PRO F CD  1 
ATOM   1685 N N   . GLU A 1 240 ? 137.725 153.458 152.644 1.00 20.36  ? 311 GLU F N   1 
ATOM   1686 C CA  . GLU A 1 240 ? 137.466 153.345 154.073 1.00 20.36  ? 311 GLU F CA  1 
ATOM   1687 C C   . GLU A 1 240 ? 137.783 151.919 154.499 1.00 20.36  ? 311 GLU F C   1 
ATOM   1688 O O   . GLU A 1 240 ? 137.234 150.963 153.937 1.00 20.36  ? 311 GLU F O   1 
ATOM   1689 C CB  . GLU A 1 240 ? 136.018 153.706 154.407 1.00 20.36  ? 311 GLU F CB  1 
ATOM   1690 C CG  . GLU A 1 240 ? 135.728 155.202 154.425 1.00 20.36  ? 311 GLU F CG  1 
ATOM   1691 C CD  . GLU A 1 240 ? 135.785 155.836 153.047 1.00 20.36  ? 311 GLU F CD  1 
ATOM   1692 O OE1 . GLU A 1 240 ? 135.691 155.097 152.044 1.00 20.36  ? 311 GLU F OE1 1 
ATOM   1693 O OE2 . GLU A 1 240 ? 135.926 157.074 152.967 1.00 20.36  ? 311 GLU F OE2 1 
ATOM   1694 N N   . VAL A 1 241 ? 138.665 151.780 155.486 1.00 20.93  ? 312 VAL F N   1 
ATOM   1695 C CA  . VAL A 1 241 ? 139.198 150.490 155.907 1.00 20.93  ? 312 VAL F CA  1 
ATOM   1696 C C   . VAL A 1 241 ? 138.862 150.284 157.377 1.00 20.93  ? 312 VAL F C   1 
ATOM   1697 O O   . VAL A 1 241 ? 139.105 151.171 158.204 1.00 20.93  ? 312 VAL F O   1 
ATOM   1698 C CB  . VAL A 1 241 ? 140.718 150.410 155.680 1.00 20.93  ? 312 VAL F CB  1 
ATOM   1699 C CG1 . VAL A 1 241 ? 141.220 148.997 155.922 1.00 20.93  ? 312 VAL F CG1 1 
ATOM   1700 C CG2 . VAL A 1 241 ? 141.069 150.883 154.278 1.00 20.93  ? 312 VAL F CG2 1 
ATOM   1701 N N   . TYR A 1 242 ? 138.306 149.118 157.699 1.00 25.42  ? 313 TYR F N   1 
ATOM   1702 C CA  . TYR A 1 242 ? 137.946 148.793 159.074 1.00 25.42  ? 313 TYR F CA  1 
ATOM   1703 C C   . TYR A 1 242 ? 138.296 147.343 159.364 1.00 25.42  ? 313 TYR F C   1 
ATOM   1704 O O   . TYR A 1 242 ? 137.991 146.457 158.563 1.00 25.42  ? 313 TYR F O   1 
ATOM   1705 C CB  . TYR A 1 242 ? 136.454 149.037 159.326 1.00 25.42  ? 313 TYR F CB  1 
ATOM   1706 C CG  . TYR A 1 242 ? 136.010 150.458 159.062 1.00 25.42  ? 313 TYR F CG  1 
ATOM   1707 C CD1 . TYR A 1 242 ? 136.126 151.436 160.041 1.00 25.42  ? 313 TYR F CD1 1 
ATOM   1708 C CD2 . TYR A 1 242 ? 135.473 150.821 157.834 1.00 25.42  ? 313 TYR F CD2 1 
ATOM   1709 C CE1 . TYR A 1 242 ? 135.721 152.736 159.804 1.00 25.42  ? 313 TYR F CE1 1 
ATOM   1710 C CE2 . TYR A 1 242 ? 135.065 152.119 157.588 1.00 25.42  ? 313 TYR F CE2 1 
ATOM   1711 C CZ  . TYR A 1 242 ? 135.191 153.072 158.576 1.00 25.42  ? 313 TYR F CZ  1 
ATOM   1712 O OH  . TYR A 1 242 ? 134.786 154.365 158.336 1.00 25.42  ? 313 TYR F OH  1 
ATOM   1713 N N   . VAL A 1 243 ? 138.914 147.097 160.516 1.00 32.08  ? 314 VAL F N   1 
ATOM   1714 C CA  . VAL A 1 243 ? 139.328 145.757 160.920 1.00 32.08  ? 314 VAL F CA  1 
ATOM   1715 C C   . VAL A 1 243 ? 138.431 145.297 162.060 1.00 32.08  ? 314 VAL F C   1 
ATOM   1716 O O   . VAL A 1 243 ? 138.307 145.986 163.080 1.00 32.08  ? 314 VAL F O   1 
ATOM   1717 C CB  . VAL A 1 243 ? 140.808 145.724 161.336 1.00 32.08  ? 314 VAL F CB  1 
ATOM   1718 C CG1 . VAL A 1 243 ? 141.237 144.297 161.632 1.00 32.08  ? 314 VAL F CG1 1 
ATOM   1719 C CG2 . VAL A 1 243 ? 141.677 146.333 160.248 1.00 32.08  ? 314 VAL F CG2 1 
ATOM   1720 N N   . PHE A 1 244 ? 137.803 144.125 161.886 1.00 25.05  ? 315 PHE F N   1 
ATOM   1721 C CA  . PHE A 1 244 ? 136.905 143.573 162.893 1.00 25.05  ? 315 PHE F CA  1 
ATOM   1722 C C   . PHE A 1 244 ? 137.637 142.557 163.753 1.00 25.05  ? 315 PHE F C   1 
ATOM   1723 O O   . PHE A 1 244 ? 138.343 141.692 163.212 1.00 25.05  ? 315 PHE F O   1 
ATOM   1724 C CB  . PHE A 1 244 ? 135.697 142.915 162.233 1.00 25.05  ? 315 PHE F CB  1 
ATOM   1725 C CG  . PHE A 1 244 ? 134.854 143.861 161.427 1.00 25.05  ? 315 PHE F CG  1 
ATOM   1726 C CD1 . PHE A 1 244 ? 133.873 144.626 162.037 1.00 25.05  ? 315 PHE F CD1 1 
ATOM   1727 C CD2 . PHE A 1 244 ? 135.039 143.984 160.060 1.00 25.05  ? 315 PHE F CD2 1 
ATOM   1728 C CE1 . PHE A 1 244 ? 133.094 145.497 161.299 1.00 25.05  ? 315 PHE F CE1 1 
ATOM   1729 C CE2 . PHE A 1 244 ? 134.264 144.853 159.317 1.00 25.05  ? 315 PHE F CE2 1 
ATOM   1730 C CZ  . PHE A 1 244 ? 133.290 145.611 159.937 1.00 25.05  ? 315 PHE F CZ  1 
ATOM   1731 N N   . PRO A 1 245 ? 137.503 142.625 165.074 1.00 27.37  ? 316 PRO F N   1 
ATOM   1732 C CA  . PRO A 1 245 ? 138.133 141.624 165.942 1.00 27.37  ? 316 PRO F CA  1 
ATOM   1733 C C   . PRO A 1 245 ? 137.488 140.263 165.755 1.00 27.37  ? 316 PRO F C   1 
ATOM   1734 O O   . PRO A 1 245 ? 136.325 140.174 165.330 1.00 27.37  ? 316 PRO F O   1 
ATOM   1735 C CB  . PRO A 1 245 ? 137.881 142.174 167.354 1.00 27.37  ? 316 PRO F CB  1 
ATOM   1736 C CG  . PRO A 1 245 ? 136.659 143.016 167.211 1.00 27.37  ? 316 PRO F CG  1 
ATOM   1737 C CD  . PRO A 1 245 ? 136.747 143.629 165.841 1.00 27.37  ? 316 PRO F CD  1 
ATOM   1738 N N   . PRO A 1 246 ? 138.211 139.183 166.041 1.00 26.17  ? 317 PRO F N   1 
ATOM   1739 C CA  . PRO A 1 246 ? 137.641 137.837 165.887 1.00 26.17  ? 317 PRO F CA  1 
ATOM   1740 C C   . PRO A 1 246 ? 136.408 137.661 166.754 1.00 26.17  ? 317 PRO F C   1 
ATOM   1741 O O   . PRO A 1 246 ? 136.375 138.121 167.906 1.00 26.17  ? 317 PRO F O   1 
ATOM   1742 C CB  . PRO A 1 246 ? 138.781 136.915 166.347 1.00 26.17  ? 317 PRO F CB  1 
ATOM   1743 C CG  . PRO A 1 246 ? 140.020 137.724 166.156 1.00 26.17  ? 317 PRO F CG  1 
ATOM   1744 C CD  . PRO A 1 246 ? 139.625 139.141 166.450 1.00 26.17  ? 317 PRO F CD  1 
ATOM   1745 N N   . PRO A 1 247 ? 135.370 137.000 166.237 1.00 27.34  ? 318 PRO F N   1 
ATOM   1746 C CA  . PRO A 1 247 ? 134.123 136.834 166.996 1.00 27.34  ? 318 PRO F CA  1 
ATOM   1747 C C   . PRO A 1 247 ? 134.208 135.666 167.968 1.00 27.34  ? 318 PRO F C   1 
ATOM   1748 O O   . PRO A 1 247 ? 134.298 134.503 167.562 1.00 27.34  ? 318 PRO F O   1 
ATOM   1749 C CB  . PRO A 1 247 ? 133.081 136.590 165.895 1.00 27.34  ? 318 PRO F CB  1 
ATOM   1750 C CG  . PRO A 1 247 ? 133.856 135.936 164.799 1.00 27.34  ? 318 PRO F CG  1 
ATOM   1751 C CD  . PRO A 1 247 ? 135.251 136.509 164.852 1.00 27.34  ? 318 PRO F CD  1 
ATOM   1752 N N   . GLU A 1 248 ? 134.177 135.980 169.265 1.00 44.76  ? 319 GLU F N   1 
ATOM   1753 C CA  . GLU A 1 248 ? 134.125 134.983 170.331 1.00 44.76  ? 319 GLU F CA  1 
ATOM   1754 C C   . GLU A 1 248 ? 135.277 133.986 170.252 1.00 44.76  ? 319 GLU F C   1 
ATOM   1755 O O   . GLU A 1 248 ? 136.308 134.262 169.630 1.00 44.76  ? 319 GLU F O   1 
ATOM   1756 C CB  . GLU A 1 248 ? 132.786 134.240 170.299 1.00 44.76  ? 319 GLU F CB  1 
ATOM   1757 C CG  . GLU A 1 248 ? 131.569 135.138 170.466 1.00 44.76  ? 319 GLU F CG  1 
ATOM   1758 C CD  . GLU A 1 248 ? 131.471 135.743 171.854 1.00 44.76  ? 319 GLU F CD  1 
ATOM   1759 O OE1 . GLU A 1 248 ? 132.057 135.173 172.799 1.00 44.76  ? 319 GLU F OE1 1 
ATOM   1760 O OE2 . GLU A 1 248 ? 130.806 136.790 172.001 1.00 44.76  ? 319 GLU F OE2 1 
ATOM   1761 N N   . GLU A 1 249 ? 135.108 132.830 170.887 1.00 48.31  ? 320 GLU F N   1 
ATOM   1762 C CA  . GLU A 1 249 ? 136.106 131.763 170.898 1.00 48.31  ? 320 GLU F CA  1 
ATOM   1763 C C   . GLU A 1 249 ? 135.539 130.598 170.089 1.00 48.31  ? 320 GLU F C   1 
ATOM   1764 O O   . GLU A 1 249 ? 134.874 129.712 170.628 1.00 48.31  ? 320 GLU F O   1 
ATOM   1765 C CB  . GLU A 1 249 ? 136.452 131.340 172.327 1.00 48.31  ? 320 GLU F CB  1 
ATOM   1766 C CG  . GLU A 1 249 ? 136.990 132.459 173.210 1.00 48.31  ? 320 GLU F CG  1 
ATOM   1767 C CD  . GLU A 1 249 ? 135.893 133.328 173.797 1.00 48.31  ? 320 GLU F CD  1 
ATOM   1768 O OE1 . GLU A 1 249 ? 134.703 133.000 173.603 1.00 48.31  ? 320 GLU F OE1 1 
ATOM   1769 O OE2 . GLU A 1 249 ? 136.221 134.338 174.454 1.00 48.31  ? 320 GLU F OE2 1 
ATOM   1770 N N   . GLU A 1 250 ? 135.808 130.607 168.785 1.00 40.19  ? 321 GLU F N   1 
ATOM   1771 C CA  . GLU A 1 250 ? 135.288 129.590 167.870 1.00 40.19  ? 321 GLU F CA  1 
ATOM   1772 C C   . GLU A 1 250 ? 136.230 128.392 167.877 1.00 40.19  ? 321 GLU F C   1 
ATOM   1773 O O   . GLU A 1 250 ? 137.162 128.300 167.077 1.00 40.19  ? 321 GLU F O   1 
ATOM   1774 C CB  . GLU A 1 250 ? 135.111 130.170 166.473 1.00 40.19  ? 321 GLU F CB  1 
ATOM   1775 C CG  . GLU A 1 250 ? 136.179 131.177 166.078 1.00 40.19  ? 321 GLU F CG  1 
ATOM   1776 C CD  . GLU A 1 250 ? 135.952 131.757 164.697 1.00 40.19  ? 321 GLU F CD  1 
ATOM   1777 O OE1 . GLU A 1 250 ? 134.916 131.436 164.079 1.00 40.19  ? 321 GLU F OE1 1 
ATOM   1778 O OE2 . GLU A 1 250 ? 136.810 132.535 164.229 1.00 40.19  ? 321 GLU F OE2 1 
ATOM   1779 N N   . SER A 1 251 ? 135.987 127.472 168.815 1.00 47.96  ? 322 SER F N   1 
ATOM   1780 C CA  . SER A 1 251 ? 136.686 126.192 168.917 1.00 47.96  ? 322 SER F CA  1 
ATOM   1781 C C   . SER A 1 251 ? 138.170 126.350 169.235 1.00 47.96  ? 322 SER F C   1 
ATOM   1782 O O   . SER A 1 251 ? 138.897 125.353 169.306 1.00 47.96  ? 322 SER F O   1 
ATOM   1783 C CB  . SER A 1 251 ? 136.512 125.376 167.631 1.00 47.96  ? 322 SER F CB  1 
ATOM   1784 O OG  . SER A 1 251 ? 137.257 125.929 166.560 1.00 47.96  ? 322 SER F OG  1 
ATOM   1785 N N   . GLU A 1 252 ? 138.625 127.590 169.432 1.00 44.93  ? 323 GLU F N   1 
ATOM   1786 C CA  . GLU A 1 252 ? 140.018 127.880 169.782 1.00 44.93  ? 323 GLU F CA  1 
ATOM   1787 C C   . GLU A 1 252 ? 140.989 127.282 168.766 1.00 44.93  ? 323 GLU F C   1 
ATOM   1788 O O   . GLU A 1 252 ? 142.070 126.801 169.114 1.00 44.93  ? 323 GLU F O   1 
ATOM   1789 C CB  . GLU A 1 252 ? 140.341 127.393 171.197 1.00 44.93  ? 323 GLU F CB  1 
ATOM   1790 C CG  . GLU A 1 252 ? 139.620 128.149 172.301 1.00 44.93  ? 323 GLU F CG  1 
ATOM   1791 C CD  . GLU A 1 252 ? 140.170 129.548 172.512 1.00 44.93  ? 323 GLU F CD  1 
ATOM   1792 O OE1 . GLU A 1 252 ? 141.271 129.842 172.001 1.00 44.93  ? 323 GLU F OE1 1 
ATOM   1793 O OE2 . GLU A 1 252 ? 139.501 130.354 173.191 1.00 44.93  ? 323 GLU F OE2 1 
ATOM   1794 N N   . ASP A 1 253 ? 140.601 127.316 167.492 1.00 42.97  ? 324 ASP F N   1 
ATOM   1795 C CA  . ASP A 1 253 ? 141.436 126.801 166.414 1.00 42.97  ? 324 ASP F CA  1 
ATOM   1796 C C   . ASP A 1 253 ? 141.636 127.774 165.264 1.00 42.97  ? 324 ASP F C   1 
ATOM   1797 O O   . ASP A 1 253 ? 142.657 127.675 164.573 1.00 42.97  ? 324 ASP F O   1 
ATOM   1798 C CB  . ASP A 1 253 ? 140.850 125.495 165.854 1.00 42.97  ? 324 ASP F CB  1 
ATOM   1799 C CG  . ASP A 1 253 ? 140.805 124.385 166.886 1.00 42.97  ? 324 ASP F CG  1 
ATOM   1800 O OD1 . ASP A 1 253 ? 141.720 124.322 167.734 1.00 42.97  ? 324 ASP F OD1 1 
ATOM   1801 O OD2 . ASP A 1 253 ? 139.855 123.576 166.850 1.00 42.97  ? 324 ASP F OD2 1 
ATOM   1802 N N   . LYS A 1 254 ? 140.710 128.701 165.031 1.00 35.28  ? 325 LYS F N   1 
ATOM   1803 C CA  . LYS A 1 254 ? 140.837 129.682 163.964 1.00 35.28  ? 325 LYS F CA  1 
ATOM   1804 C C   . LYS A 1 254 ? 140.199 130.982 164.429 1.00 35.28  ? 325 LYS F C   1 
ATOM   1805 O O   . LYS A 1 254 ? 139.185 130.963 165.130 1.00 35.28  ? 325 LYS F O   1 
ATOM   1806 C CB  . LYS A 1 254 ? 140.178 129.185 162.671 1.00 35.28  ? 325 LYS F CB  1 
ATOM   1807 C CG  . LYS A 1 254 ? 138.737 128.728 162.847 1.00 35.28  ? 325 LYS F CG  1 
ATOM   1808 C CD  . LYS A 1 254 ? 138.249 127.932 161.646 1.00 35.28  ? 325 LYS F CD  1 
ATOM   1809 C CE  . LYS A 1 254 ? 138.301 128.755 160.370 1.00 35.28  ? 325 LYS F CE  1 
ATOM   1810 N NZ  . LYS A 1 254 ? 137.788 127.993 159.198 1.00 35.28  ? 325 LYS F NZ  1 
ATOM   1811 N N   . ARG A 1 255 ? 140.800 132.106 164.046 1.00 32.82  ? 326 ARG F N   1 
ATOM   1812 C CA  . ARG A 1 255 ? 140.294 133.415 164.444 1.00 32.82  ? 326 ARG F CA  1 
ATOM   1813 C C   . ARG A 1 255 ? 139.605 134.167 163.318 1.00 32.82  ? 326 ARG F C   1 
ATOM   1814 O O   . ARG A 1 255 ? 138.608 134.850 163.564 1.00 32.82  ? 326 ARG F O   1 
ATOM   1815 C CB  . ARG A 1 255 ? 141.431 134.274 165.011 1.00 32.82  ? 326 ARG F CB  1 
ATOM   1816 C CG  . ARG A 1 255 ? 142.148 133.637 166.194 1.00 32.82  ? 326 ARG F CG  1 
ATOM   1817 C CD  . ARG A 1 255 ? 141.157 133.053 167.193 1.00 32.82  ? 326 ARG F CD  1 
ATOM   1818 N NE  . ARG A 1 255 ? 140.322 134.076 167.810 1.00 32.82  ? 326 ARG F NE  1 
ATOM   1819 C CZ  . ARG A 1 255 ? 140.441 134.482 169.067 1.00 32.82  ? 326 ARG F CZ  1 
ATOM   1820 N NH1 . ARG A 1 255 ? 141.340 133.955 169.881 1.00 32.82  ? 326 ARG F NH1 1 
ATOM   1821 N NH2 . ARG A 1 255 ? 139.632 135.435 169.520 1.00 32.82  ? 326 ARG F NH2 1 
ATOM   1822 N N   . THR A 1 256 ? 140.113 134.057 162.088 1.00 28.13  ? 327 THR F N   1 
ATOM   1823 C CA  . THR A 1 256 ? 139.477 134.608 160.889 1.00 28.13  ? 327 THR F CA  1 
ATOM   1824 C C   . THR A 1 256 ? 139.253 136.119 161.025 1.00 28.13  ? 327 THR F C   1 
ATOM   1825 O O   . THR A 1 256 ? 138.127 136.618 161.066 1.00 28.13  ? 327 THR F O   1 
ATOM   1826 C CB  . THR A 1 256 ? 138.162 133.883 160.579 1.00 28.13  ? 327 THR F CB  1 
ATOM   1827 O OG1 . THR A 1 256 ? 137.181 134.211 161.571 1.00 28.13  ? 327 THR F OG1 1 
ATOM   1828 C CG2 . THR A 1 256 ? 138.379 132.380 160.567 1.00 28.13  ? 327 THR F CG2 1 
ATOM   1829 N N   . LEU A 1 257 ? 140.373 136.834 161.098 1.00 24.92  ? 328 LEU F N   1 
ATOM   1830 C CA  . LEU A 1 257 ? 140.320 138.289 161.125 1.00 24.92  ? 328 LEU F CA  1 
ATOM   1831 C C   . LEU A 1 257 ? 139.778 138.825 159.807 1.00 24.92  ? 328 LEU F C   1 
ATOM   1832 O O   . LEU A 1 257 ? 140.115 138.329 158.728 1.00 24.92  ? 328 LEU F O   1 
ATOM   1833 C CB  . LEU A 1 257 ? 141.705 138.876 161.396 1.00 24.92  ? 328 LEU F CB  1 
ATOM   1834 C CG  . LEU A 1 257 ? 142.129 139.012 162.860 1.00 24.92  ? 328 LEU F CG  1 
ATOM   1835 C CD1 . LEU A 1 257 ? 142.552 137.671 163.440 1.00 24.92  ? 328 LEU F CD1 1 
ATOM   1836 C CD2 . LEU A 1 257 ? 143.238 140.043 162.995 1.00 24.92  ? 328 LEU F CD2 1 
ATOM   1837 N N   . THR A 1 258 ? 138.934 139.849 159.899 1.00 21.24  ? 329 THR F N   1 
ATOM   1838 C CA  . THR A 1 258 ? 138.272 140.438 158.744 1.00 21.24  ? 329 THR F CA  1 
ATOM   1839 C C   . THR A 1 258 ? 138.713 141.886 158.585 1.00 21.24  ? 329 THR F C   1 
ATOM   1840 O O   . THR A 1 258 ? 138.727 142.647 159.559 1.00 21.24  ? 329 THR F O   1 
ATOM   1841 C CB  . THR A 1 258 ? 136.748 140.364 158.885 1.00 21.24  ? 329 THR F CB  1 
ATOM   1842 O OG1 . THR A 1 258 ? 136.345 138.996 159.026 1.00 21.24  ? 329 THR F OG1 1 
ATOM   1843 C CG2 . THR A 1 258 ? 136.065 140.964 157.665 1.00 21.24  ? 329 THR F CG2 1 
ATOM   1844 N N   . CYS A 1 259 ? 139.083 142.257 157.361 1.00 25.42  ? 330 CYS F N   1 
ATOM   1845 C CA  . CYS A 1 259 ? 139.415 143.634 157.009 1.00 25.42  ? 330 CYS F CA  1 
ATOM   1846 C C   . CYS A 1 259 ? 138.499 144.052 155.866 1.00 25.42  ? 330 CYS F C   1 
ATOM   1847 O O   . CYS A 1 259 ? 138.616 143.534 154.751 1.00 25.42  ? 330 CYS F O   1 
ATOM   1848 C CB  . CYS A 1 259 ? 140.888 143.766 156.621 1.00 25.42  ? 330 CYS F CB  1 
ATOM   1849 S SG  . CYS A 1 259 ? 141.421 145.449 156.218 1.00 25.42  ? 330 CYS F SG  1 
ATOM   1850 N N   . LEU A 1 260 ? 137.580 144.971 156.147 1.00 19.64  ? 331 LEU F N   1 
ATOM   1851 C CA  . LEU A 1 260 ? 136.614 145.449 155.168 1.00 19.64  ? 331 LEU F CA  1 
ATOM   1852 C C   . LEU A 1 260 ? 137.116 146.754 154.566 1.00 19.64  ? 331 LEU F C   1 
ATOM   1853 O O   . LEU A 1 260 ? 137.418 147.706 155.297 1.00 19.64  ? 331 LEU F O   1 
ATOM   1854 C CB  . LEU A 1 260 ? 135.239 145.646 155.808 1.00 19.64  ? 331 LEU F CB  1 
ATOM   1855 C CG  . LEU A 1 260 ? 134.228 146.494 155.030 1.00 19.64  ? 331 LEU F CG  1 
ATOM   1856 C CD1 . LEU A 1 260 ? 133.950 145.907 153.652 1.00 19.64  ? 331 LEU F CD1 1 
ATOM   1857 C CD2 . LEU A 1 260 ? 132.937 146.646 155.821 1.00 19.64  ? 331 LEU F CD2 1 
ATOM   1858 N N   . ILE A 1 261 ? 137.203 146.791 153.240 1.00 16.81  ? 332 ILE F N   1 
ATOM   1859 C CA  . ILE A 1 261 ? 137.584 147.987 152.497 1.00 16.81  ? 332 ILE F CA  1 
ATOM   1860 C C   . ILE A 1 261 ? 136.414 148.352 151.597 1.00 16.81  ? 332 ILE F C   1 
ATOM   1861 O O   . ILE A 1 261 ? 135.952 147.521 150.804 1.00 16.81  ? 332 ILE F O   1 
ATOM   1862 C CB  . ILE A 1 261 ? 138.863 147.767 151.676 1.00 16.81  ? 332 ILE F CB  1 
ATOM   1863 C CG1 . ILE A 1 261 ? 139.932 147.090 152.535 1.00 16.81  ? 332 ILE F CG1 1 
ATOM   1864 C CG2 . ILE A 1 261 ? 139.375 149.088 151.123 1.00 16.81  ? 332 ILE F CG2 1 
ATOM   1865 C CD1 . ILE A 1 261 ? 141.067 146.503 151.737 1.00 16.81  ? 332 ILE F CD1 1 
ATOM   1866 N N   . GLN A 1 262 ? 135.934 149.588 151.717 1.00 20.21  ? 333 GLN F N   1 
ATOM   1867 C CA  . GLN A 1 262 ? 134.739 150.006 151.000 1.00 20.21  ? 333 GLN F CA  1 
ATOM   1868 C C   . GLN A 1 262 ? 134.911 151.424 150.474 1.00 20.21  ? 333 GLN F C   1 
ATOM   1869 O O   . GLN A 1 262 ? 135.731 152.200 150.971 1.00 20.21  ? 333 GLN F O   1 
ATOM   1870 C CB  . GLN A 1 262 ? 133.492 149.922 151.892 1.00 20.21  ? 333 GLN F CB  1 
ATOM   1871 C CG  . GLN A 1 262 ? 133.570 150.766 153.153 1.00 20.21  ? 333 GLN F CG  1 
ATOM   1872 C CD  . GLN A 1 262 ? 132.338 150.625 154.024 1.00 20.21  ? 333 GLN F CD  1 
ATOM   1873 O OE1 . GLN A 1 262 ? 131.415 149.878 153.698 1.00 20.21  ? 333 GLN F OE1 1 
ATOM   1874 N NE2 . GLN A 1 262 ? 132.317 151.343 155.141 1.00 20.21  ? 333 GLN F NE2 1 
ATOM   1875 N N   . ASN A 1 263 ? 134.121 151.743 149.448 1.00 23.29  ? 334 ASN F N   1 
ATOM   1876 C CA  . ASN A 1 263 ? 134.048 153.082 148.863 1.00 23.29  ? 334 ASN F CA  1 
ATOM   1877 C C   . ASN A 1 263 ? 135.407 153.530 148.317 1.00 23.29  ? 334 ASN F C   1 
ATOM   1878 O O   . ASN A 1 263 ? 135.988 154.526 148.752 1.00 23.29  ? 334 ASN F O   1 
ATOM   1879 C CB  . ASN A 1 263 ? 133.499 154.091 149.878 1.00 23.29  ? 334 ASN F CB  1 
ATOM   1880 C CG  . ASN A 1 263 ? 132.115 153.723 150.375 1.00 23.29  ? 334 ASN F CG  1 
ATOM   1881 O OD1 . ASN A 1 263 ? 131.329 153.104 149.658 1.00 23.29  ? 334 ASN F OD1 1 
ATOM   1882 N ND2 . ASN A 1 263 ? 131.810 154.102 151.611 1.00 23.29  ? 334 ASN F ND2 1 
ATOM   1883 N N   . PHE A 1 264 ? 135.907 152.768 147.346 1.00 16.99  ? 335 PHE F N   1 
ATOM   1884 C CA  . PHE A 1 264 ? 137.114 153.140 146.623 1.00 16.99  ? 335 PHE F CA  1 
ATOM   1885 C C   . PHE A 1 264 ? 136.904 152.894 145.137 1.00 16.99  ? 335 PHE F C   1 
ATOM   1886 O O   . PHE A 1 264 ? 136.191 151.969 144.739 1.00 16.99  ? 335 PHE F O   1 
ATOM   1887 C CB  . PHE A 1 264 ? 138.349 152.372 147.125 1.00 16.99  ? 335 PHE F CB  1 
ATOM   1888 C CG  . PHE A 1 264 ? 138.359 150.914 146.756 1.00 16.99  ? 335 PHE F CG  1 
ATOM   1889 C CD1 . PHE A 1 264 ? 137.736 149.976 147.561 1.00 16.99  ? 335 PHE F CD1 1 
ATOM   1890 C CD2 . PHE A 1 264 ? 139.013 150.479 145.614 1.00 16.99  ? 335 PHE F CD2 1 
ATOM   1891 C CE1 . PHE A 1 264 ? 137.753 148.634 147.225 1.00 16.99  ? 335 PHE F CE1 1 
ATOM   1892 C CE2 . PHE A 1 264 ? 139.029 149.141 145.273 1.00 16.99  ? 335 PHE F CE2 1 
ATOM   1893 C CZ  . PHE A 1 264 ? 138.399 148.217 146.080 1.00 16.99  ? 335 PHE F CZ  1 
ATOM   1894 N N   . PHE A 1 265 ? 137.536 153.737 144.318 1.00 15.40  ? 336 PHE F N   1 
ATOM   1895 C CA  . PHE A 1 265 ? 137.440 153.647 142.871 1.00 15.40  ? 336 PHE F CA  1 
ATOM   1896 C C   . PHE A 1 265 ? 138.763 154.109 142.280 1.00 15.40  ? 336 PHE F C   1 
ATOM   1897 O O   . PHE A 1 265 ? 139.300 155.136 142.720 1.00 15.40  ? 336 PHE F O   1 
ATOM   1898 C CB  . PHE A 1 265 ? 136.290 154.499 142.322 1.00 15.40  ? 336 PHE F CB  1 
ATOM   1899 C CG  . PHE A 1 265 ? 136.065 154.339 140.846 1.00 15.40  ? 336 PHE F CG  1 
ATOM   1900 C CD1 . PHE A 1 265 ? 135.284 153.303 140.360 1.00 15.40  ? 336 PHE F CD1 1 
ATOM   1901 C CD2 . PHE A 1 265 ? 136.628 155.226 139.943 1.00 15.40  ? 336 PHE F CD2 1 
ATOM   1902 C CE1 . PHE A 1 265 ? 135.072 153.153 139.002 1.00 15.40  ? 336 PHE F CE1 1 
ATOM   1903 C CE2 . PHE A 1 265 ? 136.421 155.081 138.584 1.00 15.40  ? 336 PHE F CE2 1 
ATOM   1904 C CZ  . PHE A 1 265 ? 135.642 154.043 138.114 1.00 15.40  ? 336 PHE F CZ  1 
ATOM   1905 N N   . PRO A 1 266 ? 139.309 153.391 141.289 1.00 15.81  ? 337 PRO F N   1 
ATOM   1906 C CA  . PRO A 1 266 ? 138.781 152.178 140.649 1.00 15.81  ? 337 PRO F CA  1 
ATOM   1907 C C   . PRO A 1 266 ? 139.045 150.914 141.462 1.00 15.81  ? 337 PRO F C   1 
ATOM   1908 O O   . PRO A 1 266 ? 139.551 150.975 142.578 1.00 15.81  ? 337 PRO F O   1 
ATOM   1909 C CB  . PRO A 1 266 ? 139.526 152.157 139.310 1.00 15.81  ? 337 PRO F CB  1 
ATOM   1910 C CG  . PRO A 1 266 ? 140.864 152.746 139.645 1.00 15.81  ? 337 PRO F CG  1 
ATOM   1911 C CD  . PRO A 1 266 ? 140.578 153.820 140.671 1.00 15.81  ? 337 PRO F CD  1 
ATOM   1912 N N   . GLU A 1 267 ? 138.705 149.748 140.908 1.00 16.81  ? 338 GLU F N   1 
ATOM   1913 C CA  . GLU A 1 267 ? 138.864 148.484 141.618 1.00 16.81  ? 338 GLU F CA  1 
ATOM   1914 C C   . GLU A 1 267 ? 140.321 148.084 141.816 1.00 16.81  ? 338 GLU F C   1 
ATOM   1915 O O   . GLU A 1 267 ? 140.590 147.181 142.615 1.00 16.81  ? 338 GLU F O   1 
ATOM   1916 C CB  . GLU A 1 267 ? 138.121 147.373 140.873 1.00 16.81  ? 338 GLU F CB  1 
ATOM   1917 C CG  . GLU A 1 267 ? 138.555 147.199 139.426 1.00 16.81  ? 338 GLU F CG  1 
ATOM   1918 C CD  . GLU A 1 267 ? 137.743 146.146 138.698 1.00 16.81  ? 338 GLU F CD  1 
ATOM   1919 O OE1 . GLU A 1 267 ? 136.843 145.548 139.325 1.00 16.81  ? 338 GLU F OE1 1 
ATOM   1920 O OE2 . GLU A 1 267 ? 138.005 145.916 137.498 1.00 16.81  ? 338 GLU F OE2 1 
ATOM   1921 N N   . ASP A 1 268 ? 141.258 148.720 141.115 1.00 14.01  ? 339 ASP F N   1 
ATOM   1922 C CA  . ASP A 1 268 ? 142.676 148.408 141.274 1.00 14.01  ? 339 ASP F CA  1 
ATOM   1923 C C   . ASP A 1 268 ? 143.128 148.817 142.670 1.00 14.01  ? 339 ASP F C   1 
ATOM   1924 O O   . ASP A 1 268 ? 143.202 150.009 142.984 1.00 14.01  ? 339 ASP F O   1 
ATOM   1925 C CB  . ASP A 1 268 ? 143.496 149.118 140.201 1.00 14.01  ? 339 ASP F CB  1 
ATOM   1926 C CG  . ASP A 1 268 ? 143.105 148.700 138.797 1.00 14.01  ? 339 ASP F CG  1 
ATOM   1927 O OD1 . ASP A 1 268 ? 142.666 147.544 138.620 1.00 14.01  ? 339 ASP F OD1 1 
ATOM   1928 O OD2 . ASP A 1 268 ? 143.236 149.528 137.871 1.00 14.01  ? 339 ASP F OD2 1 
ATOM   1929 N N   . ILE A 1 269 ? 143.436 147.829 143.511 1.00 13.89  ? 340 ILE F N   1 
ATOM   1930 C CA  . ILE A 1 269 ? 143.771 148.073 144.908 1.00 13.89  ? 340 ILE F CA  1 
ATOM   1931 C C   . ILE A 1 269 ? 144.650 146.930 145.397 1.00 13.89  ? 340 ILE F C   1 
ATOM   1932 O O   . ILE A 1 269 ? 144.563 145.802 144.904 1.00 13.89  ? 340 ILE F O   1 
ATOM   1933 C CB  . ILE A 1 269 ? 142.491 148.218 145.768 1.00 13.89  ? 340 ILE F CB  1 
ATOM   1934 C CG1 . ILE A 1 269 ? 142.815 148.778 147.154 1.00 13.89  ? 340 ILE F CG1 1 
ATOM   1935 C CG2 . ILE A 1 269 ? 141.763 146.886 145.883 1.00 13.89  ? 340 ILE F CG2 1 
ATOM   1936 C CD1 . ILE A 1 269 ? 141.590 148.993 148.014 1.00 13.89  ? 340 ILE F CD1 1 
ATOM   1937 N N   . SER A 1 270 ? 145.515 147.231 146.364 1.00 14.64  ? 341 SER F N   1 
ATOM   1938 C CA  . SER A 1 270 ? 146.407 146.242 146.955 1.00 14.64  ? 341 SER F CA  1 
ATOM   1939 C C   . SER A 1 270 ? 146.072 146.072 148.429 1.00 14.64  ? 341 SER F C   1 
ATOM   1940 O O   . SER A 1 270 ? 145.984 147.059 149.166 1.00 14.64  ? 341 SER F O   1 
ATOM   1941 C CB  . SER A 1 270 ? 147.874 146.648 146.787 1.00 14.64  ? 341 SER F CB  1 
ATOM   1942 O OG  . SER A 1 270 ? 148.248 146.657 145.421 1.00 14.64  ? 341 SER F OG  1 
ATOM   1943 N N   . VAL A 1 271 ? 145.892 144.823 148.854 1.00 13.36  ? 342 VAL F N   1 
ATOM   1944 C CA  . VAL A 1 271 ? 145.558 144.487 150.233 1.00 13.36  ? 342 VAL F CA  1 
ATOM   1945 C C   . VAL A 1 271 ? 146.643 143.569 150.777 1.00 13.36  ? 342 VAL F C   1 
ATOM   1946 O O   . VAL A 1 271 ? 147.001 142.577 150.132 1.00 13.36  ? 342 VAL F O   1 
ATOM   1947 C CB  . VAL A 1 271 ? 144.176 143.814 150.336 1.00 13.36  ? 342 VAL F CB  1 
ATOM   1948 C CG1 . VAL A 1 271 ? 143.732 143.727 151.789 1.00 13.36  ? 342 VAL F CG1 1 
ATOM   1949 C CG2 . VAL A 1 271 ? 143.153 144.562 149.494 1.00 13.36  ? 342 VAL F CG2 1 
ATOM   1950 N N   . GLN A 1 272 ? 147.164 143.898 151.958 1.00 16.02  ? 343 GLN F N   1 
ATOM   1951 C CA  . GLN A 1 272 ? 148.215 143.104 152.578 1.00 16.02  ? 343 GLN F CA  1 
ATOM   1952 C C   . GLN A 1 272 ? 147.952 142.971 154.071 1.00 16.02  ? 343 GLN F C   1 
ATOM   1953 O O   . GLN A 1 272 ? 147.281 143.804 154.685 1.00 16.02  ? 343 GLN F O   1 
ATOM   1954 C CB  . GLN A 1 272 ? 149.603 143.716 152.345 1.00 16.02  ? 343 GLN F CB  1 
ATOM   1955 C CG  . GLN A 1 272 ? 150.121 143.573 150.924 1.00 16.02  ? 343 GLN F CG  1 
ATOM   1956 C CD  . GLN A 1 272 ? 151.507 144.163 150.751 1.00 16.02  ? 343 GLN F CD  1 
ATOM   1957 O OE1 . GLN A 1 272 ? 152.426 143.492 150.283 1.00 16.02  ? 343 GLN F OE1 1 
ATOM   1958 N NE2 . GLN A 1 272 ? 151.663 145.427 151.128 1.00 16.02  ? 343 GLN F NE2 1 
ATOM   1959 N N   . TRP A 1 273 ? 148.497 141.904 154.650 1.00 21.88  ? 344 TRP F N   1 
ATOM   1960 C CA  . TRP A 1 273 ? 148.450 141.662 156.085 1.00 21.88  ? 344 TRP F CA  1 
ATOM   1961 C C   . TRP A 1 273 ? 149.872 141.605 156.622 1.00 21.88  ? 344 TRP F C   1 
ATOM   1962 O O   . TRP A 1 273 ? 150.725 140.914 156.055 1.00 21.88  ? 344 TRP F O   1 
ATOM   1963 C CB  . TRP A 1 273 ? 147.711 140.360 156.405 1.00 21.88  ? 344 TRP F CB  1 
ATOM   1964 C CG  . TRP A 1 273 ? 146.244 140.407 156.116 1.00 21.88  ? 344 TRP F CG  1 
ATOM   1965 C CD1 . TRP A 1 273 ? 145.637 140.185 154.915 1.00 21.88  ? 344 TRP F CD1 1 
ATOM   1966 C CD2 . TRP A 1 273 ? 145.194 140.687 157.050 1.00 21.88  ? 344 TRP F CD2 1 
ATOM   1967 N NE1 . TRP A 1 273 ? 144.275 140.312 155.041 1.00 21.88  ? 344 TRP F NE1 1 
ATOM   1968 C CE2 . TRP A 1 273 ? 143.978 140.620 156.343 1.00 21.88  ? 344 TRP F CE2 1 
ATOM   1969 C CE3 . TRP A 1 273 ? 145.165 140.991 158.415 1.00 21.88  ? 344 TRP F CE3 1 
ATOM   1970 C CZ2 . TRP A 1 273 ? 142.746 140.844 156.954 1.00 21.88  ? 344 TRP F CZ2 1 
ATOM   1971 C CZ3 . TRP A 1 273 ? 143.942 141.212 159.019 1.00 21.88  ? 344 TRP F CZ3 1 
ATOM   1972 C CH2 . TRP A 1 273 ? 142.749 141.138 158.289 1.00 21.88  ? 344 TRP F CH2 1 
ATOM   1973 N N   . LEU A 1 274 ? 150.125 142.332 157.707 1.00 24.48  ? 345 LEU F N   1 
ATOM   1974 C CA  . LEU A 1 274 ? 151.437 142.379 158.337 1.00 24.48  ? 345 LEU F CA  1 
ATOM   1975 C C   . LEU A 1 274 ? 151.327 141.871 159.766 1.00 24.48  ? 345 LEU F C   1 
ATOM   1976 O O   . LEU A 1 274 ? 150.492 142.354 160.538 1.00 24.48  ? 345 LEU F O   1 
ATOM   1977 C CB  . LEU A 1 274 ? 152.014 143.800 158.323 1.00 24.48  ? 345 LEU F CB  1 
ATOM   1978 C CG  . LEU A 1 274 ? 152.604 144.336 157.014 1.00 24.48  ? 345 LEU F CG  1 
ATOM   1979 C CD1 . LEU A 1 274 ? 151.522 144.645 155.988 1.00 24.48  ? 345 LEU F CD1 1 
ATOM   1980 C CD2 . LEU A 1 274 ? 153.460 145.565 157.280 1.00 24.48  ? 345 LEU F CD2 1 
ATOM   1981 N N   . GLY A 1 275 ? 152.165 140.897 160.111 1.00 33.29  ? 346 GLY F N   1 
ATOM   1982 C CA  . GLY A 1 275 ? 152.196 140.368 161.460 1.00 33.29  ? 346 GLY F CA  1 
ATOM   1983 C C   . GLY A 1 275 ? 153.424 140.809 162.229 1.00 33.29  ? 346 GLY F C   1 
ATOM   1984 O O   . GLY A 1 275 ? 154.528 140.314 161.980 1.00 33.29  ? 346 GLY F O   1 
ATOM   1985 N N   . ASP A 1 276 ? 153.238 141.739 163.169 1.00 43.02  ? 347 ASP F N   1 
ATOM   1986 C CA  . ASP A 1 276 ? 154.334 142.291 163.969 1.00 43.02  ? 347 ASP F CA  1 
ATOM   1987 C C   . ASP A 1 276 ? 155.438 142.862 163.081 1.00 43.02  ? 347 ASP F C   1 
ATOM   1988 O O   . ASP A 1 276 ? 156.629 142.683 163.345 1.00 43.02  ? 347 ASP F O   1 
ATOM   1989 C CB  . ASP A 1 276 ? 154.897 141.246 164.935 1.00 43.02  ? 347 ASP F CB  1 
ATOM   1990 C CG  . ASP A 1 276 ? 153.859 140.746 165.921 1.00 43.02  ? 347 ASP F CG  1 
ATOM   1991 O OD1 . ASP A 1 276 ? 152.701 141.209 165.852 1.00 43.02  ? 347 ASP F OD1 1 
ATOM   1992 O OD2 . ASP A 1 276 ? 154.202 139.891 166.764 1.00 43.02  ? 347 ASP F OD2 1 
ATOM   1993 N N   . GLY A 1 277 ? 155.039 143.556 162.017 1.00 32.99  ? 348 GLY F N   1 
ATOM   1994 C CA  . GLY A 1 277 ? 155.979 144.143 161.088 1.00 32.99  ? 348 GLY F CA  1 
ATOM   1995 C C   . GLY A 1 277 ? 156.502 143.210 160.018 1.00 32.99  ? 348 GLY F C   1 
ATOM   1996 O O   . GLY A 1 277 ? 157.379 143.616 159.244 1.00 32.99  ? 348 GLY F O   1 
ATOM   1997 N N   . LYS A 1 278 ? 156.001 141.980 159.945 1.00 29.56  ? 349 LYS F N   1 
ATOM   1998 C CA  . LYS A 1 278 ? 156.431 141.007 158.950 1.00 29.56  ? 349 LYS F CA  1 
ATOM   1999 C C   . LYS A 1 278 ? 155.282 140.723 157.993 1.00 29.56  ? 349 LYS F C   1 
ATOM   2000 O O   . LYS A 1 278 ? 154.153 140.471 158.430 1.00 29.56  ? 349 LYS F O   1 
ATOM   2001 C CB  . LYS A 1 278 ? 156.902 139.712 159.615 1.00 29.56  ? 349 LYS F CB  1 
ATOM   2002 C CG  . LYS A 1 278 ? 157.458 138.684 158.644 1.00 29.56  ? 349 LYS F CG  1 
ATOM   2003 C CD  . LYS A 1 278 ? 157.939 137.438 159.370 1.00 29.56  ? 349 LYS F CD  1 
ATOM   2004 C CE  . LYS A 1 278 ? 156.798 136.749 160.100 1.00 29.56  ? 349 LYS F CE  1 
ATOM   2005 N NZ  . LYS A 1 278 ? 155.726 136.312 159.163 1.00 29.56  ? 349 LYS F NZ  1 
ATOM   2006 N N   . LEU A 1 279 ? 155.572 140.768 156.696 1.00 26.23  ? 350 LEU F N   1 
ATOM   2007 C CA  . LEU A 1 279 ? 154.546 140.540 155.687 1.00 26.23  ? 350 LEU F CA  1 
ATOM   2008 C C   . LEU A 1 279 ? 154.054 139.098 155.732 1.00 26.23  ? 350 LEU F C   1 
ATOM   2009 O O   . LEU A 1 279 ? 154.833 138.163 155.936 1.00 26.23  ? 350 LEU F O   1 
ATOM   2010 C CB  . LEU A 1 279 ? 155.089 140.870 154.297 1.00 26.23  ? 350 LEU F CB  1 
ATOM   2011 C CG  . LEU A 1 279 ? 154.110 140.754 153.126 1.00 26.23  ? 350 LEU F CG  1 
ATOM   2012 C CD1 . LEU A 1 279 ? 152.925 141.687 153.322 1.00 26.23  ? 350 LEU F CD1 1 
ATOM   2013 C CD2 . LEU A 1 279 ? 154.812 141.043 151.808 1.00 26.23  ? 350 LEU F CD2 1 
ATOM   2014 N N   . ILE A 1 280 ? 152.749 138.924 155.539 1.00 26.33  ? 351 ILE F N   1 
ATOM   2015 C CA  . ILE A 1 280 ? 152.111 137.613 155.540 1.00 26.33  ? 351 ILE F CA  1 
ATOM   2016 C C   . ILE A 1 280 ? 151.865 137.189 154.100 1.00 26.33  ? 351 ILE F C   1 
ATOM   2017 O O   . ILE A 1 280 ? 151.399 137.986 153.275 1.00 26.33  ? 351 ILE F O   1 
ATOM   2018 C CB  . ILE A 1 280 ? 150.799 137.633 156.348 1.00 26.33  ? 351 ILE F CB  1 
ATOM   2019 C CG1 . ILE A 1 280 ? 151.067 138.092 157.782 1.00 26.33  ? 351 ILE F CG1 1 
ATOM   2020 C CG2 . ILE A 1 280 ? 150.142 136.261 156.341 1.00 26.33  ? 351 ILE F CG2 1 
ATOM   2021 C CD1 . ILE A 1 280 ? 149.830 138.144 158.650 1.00 26.33  ? 351 ILE F CD1 1 
ATOM   2022 N N   . SER A 1 281 ? 152.185 135.933 153.794 1.00 26.47  ? 352 SER F N   1 
ATOM   2023 C CA  . SER A 1 281 ? 152.050 135.432 152.433 1.00 26.47  ? 352 SER F CA  1 
ATOM   2024 C C   . SER A 1 281 ? 150.587 135.415 152.003 1.00 26.47  ? 352 SER F C   1 
ATOM   2025 O O   . SER A 1 281 ? 149.672 135.297 152.823 1.00 26.47  ? 352 SER F O   1 
ATOM   2026 C CB  . SER A 1 281 ? 152.645 134.027 152.323 1.00 26.47  ? 352 SER F CB  1 
ATOM   2027 O OG  . SER A 1 281 ? 151.986 133.124 153.194 1.00 26.47  ? 352 SER F OG  1 
ATOM   2028 N N   . ASN A 1 282 ? 150.374 135.536 150.690 1.00 25.57  ? 353 ASN F N   1 
ATOM   2029 C CA  . ASN A 1 282 ? 149.031 135.580 150.124 1.00 25.57  ? 353 ASN F CA  1 
ATOM   2030 C C   . ASN A 1 282 ? 148.278 134.265 150.278 1.00 25.57  ? 353 ASN F C   1 
ATOM   2031 O O   . ASN A 1 282 ? 147.056 134.248 150.098 1.00 25.57  ? 353 ASN F O   1 
ATOM   2032 C CB  . ASN A 1 282 ? 149.108 135.966 148.644 1.00 25.57  ? 353 ASN F CB  1 
ATOM   2033 C CG  . ASN A 1 282 ? 147.755 136.326 148.060 1.00 25.57  ? 353 ASN F CG  1 
ATOM   2034 O OD1 . ASN A 1 282 ? 146.848 136.747 148.777 1.00 25.57  ? 353 ASN F OD1 1 
ATOM   2035 N ND2 . ASN A 1 282 ? 147.614 136.160 146.750 1.00 25.57  ? 353 ASN F ND2 1 
ATOM   2036 N N   . SER A 1 283 ? 148.967 133.168 150.599 1.00 27.45  ? 354 SER F N   1 
ATOM   2037 C CA  . SER A 1 283 ? 148.281 131.890 150.761 1.00 27.45  ? 354 SER F CA  1 
ATOM   2038 C C   . SER A 1 283 ? 147.418 131.876 152.017 1.00 27.45  ? 354 SER F C   1 
ATOM   2039 O O   . SER A 1 283 ? 146.345 131.262 152.032 1.00 27.45  ? 354 SER F O   1 
ATOM   2040 C CB  . SER A 1 283 ? 149.299 130.750 150.796 1.00 27.45  ? 354 SER F CB  1 
ATOM   2041 O OG  . SER A 1 283 ? 150.204 130.907 151.875 1.00 27.45  ? 354 SER F OG  1 
ATOM   2042 N N   . GLN A 1 284 ? 147.869 132.544 153.082 1.00 26.34  ? 355 GLN F N   1 
ATOM   2043 C CA  . GLN A 1 284 ? 147.145 132.489 154.349 1.00 26.34  ? 355 GLN F CA  1 
ATOM   2044 C C   . GLN A 1 284 ? 145.872 133.326 154.308 1.00 26.34  ? 355 GLN F C   1 
ATOM   2045 O O   . GLN A 1 284 ? 144.835 132.912 154.839 1.00 26.34  ? 355 GLN F O   1 
ATOM   2046 C CB  . GLN A 1 284 ? 148.051 132.949 155.490 1.00 26.34  ? 355 GLN F CB  1 
ATOM   2047 C CG  . GLN A 1 284 ? 149.345 132.160 155.612 1.00 26.34  ? 355 GLN F CG  1 
ATOM   2048 C CD  . GLN A 1 284 ? 150.149 132.546 156.838 1.00 26.34  ? 355 GLN F CD  1 
ATOM   2049 O OE1 . GLN A 1 284 ? 149.594 132.981 157.847 1.00 26.34  ? 355 GLN F OE1 1 
ATOM   2050 N NE2 . GLN A 1 284 ? 151.466 132.393 156.754 1.00 26.34  ? 355 GLN F NE2 1 
ATOM   2051 N N   . HIS A 1 285 ? 145.925 134.501 153.687 1.00 21.81  ? 356 HIS F N   1 
ATOM   2052 C CA  . HIS A 1 285 ? 144.799 135.424 153.658 1.00 21.81  ? 356 HIS F CA  1 
ATOM   2053 C C   . HIS A 1 285 ? 144.164 135.439 152.275 1.00 21.81  ? 356 HIS F C   1 
ATOM   2054 O O   . HIS A 1 285 ? 144.864 135.437 151.258 1.00 21.81  ? 356 HIS F O   1 
ATOM   2055 C CB  . HIS A 1 285 ? 145.236 136.840 154.049 1.00 21.81  ? 356 HIS F CB  1 
ATOM   2056 C CG  . HIS A 1 285 ? 146.189 137.472 153.082 1.00 21.81  ? 356 HIS F CG  1 
ATOM   2057 N ND1 . HIS A 1 285 ? 145.770 138.112 151.936 1.00 21.81  ? 356 HIS F ND1 1 
ATOM   2058 C CD2 . HIS A 1 285 ? 147.540 137.564 153.092 1.00 21.81  ? 356 HIS F CD2 1 
ATOM   2059 C CE1 . HIS A 1 285 ? 146.822 138.571 151.281 1.00 21.81  ? 356 HIS F CE1 1 
ATOM   2060 N NE2 . HIS A 1 285 ? 147.908 138.251 151.961 1.00 21.81  ? 356 HIS F NE2 1 
ATOM   2061 N N   . SER A 1 286 ? 142.835 135.455 152.244 1.00 18.96  ? 357 SER F N   1 
ATOM   2062 C CA  . SER A 1 286 ? 142.072 135.448 151.004 1.00 18.96  ? 357 SER F CA  1 
ATOM   2063 C C   . SER A 1 286 ? 141.308 136.758 150.866 1.00 18.96  ? 357 SER F C   1 
ATOM   2064 O O   . SER A 1 286 ? 140.607 137.174 151.794 1.00 18.96  ? 357 SER F O   1 
ATOM   2065 C CB  . SER A 1 286 ? 141.105 134.263 150.962 1.00 18.96  ? 357 SER F CB  1 
ATOM   2066 O OG  . SER A 1 286 ? 140.361 134.254 149.756 1.00 18.96  ? 357 SER F OG  1 
ATOM   2067 N N   . THR A 1 287 ? 141.444 137.399 149.709 1.00 17.38  ? 358 THR F N   1 
ATOM   2068 C CA  . THR A 1 287 ? 140.763 138.651 149.412 1.00 17.38  ? 358 THR F CA  1 
ATOM   2069 C C   . THR A 1 287 ? 139.645 138.390 148.412 1.00 17.38  ? 358 THR F C   1 
ATOM   2070 O O   . THR A 1 287 ? 139.886 137.830 147.337 1.00 17.38  ? 358 THR F O   1 
ATOM   2071 C CB  . THR A 1 287 ? 141.738 139.691 148.855 1.00 17.38  ? 358 THR F CB  1 
ATOM   2072 O OG1 . THR A 1 287 ? 142.776 139.937 149.812 1.00 17.38  ? 358 THR F OG1 1 
ATOM   2073 C CG2 . THR A 1 287 ? 141.013 140.995 148.555 1.00 17.38  ? 358 THR F CG2 1 
ATOM   2074 N N   . THR A 1 288 ? 138.429 138.794 148.769 1.00 17.04  ? 359 THR F N   1 
ATOM   2075 C CA  . THR A 1 288 ? 137.286 138.600 147.891 1.00 17.04  ? 359 THR F CA  1 
ATOM   2076 C C   . THR A 1 288 ? 137.391 139.497 146.662 1.00 17.04  ? 359 THR F C   1 
ATOM   2077 O O   . THR A 1 288 ? 137.993 140.574 146.698 1.00 17.04  ? 359 THR F O   1 
ATOM   2078 C CB  . THR A 1 288 ? 135.982 138.890 148.635 1.00 17.04  ? 359 THR F CB  1 
ATOM   2079 O OG1 . THR A 1 288 ? 135.984 140.246 149.097 1.00 17.04  ? 359 THR F OG1 1 
ATOM   2080 C CG2 . THR A 1 288 ? 135.829 137.954 149.825 1.00 17.04  ? 359 THR F CG2 1 
ATOM   2081 N N   . THR A 1 289 ? 136.802 139.036 145.563 1.00 19.50  ? 360 THR F N   1 
ATOM   2082 C CA  . THR A 1 289 ? 136.812 139.815 144.335 1.00 19.50  ? 360 THR F CA  1 
ATOM   2083 C C   . THR A 1 289 ? 135.985 141.087 144.515 1.00 19.50  ? 360 THR F C   1 
ATOM   2084 O O   . THR A 1 289 ? 134.952 141.065 145.191 1.00 19.50  ? 360 THR F O   1 
ATOM   2085 C CB  . THR A 1 289 ? 136.259 138.994 143.170 1.00 19.50  ? 360 THR F CB  1 
ATOM   2086 O OG1 . THR A 1 289 ? 134.912 138.600 143.458 1.00 19.50  ? 360 THR F OG1 1 
ATOM   2087 C CG2 . THR A 1 289 ? 137.108 137.752 142.943 1.00 19.50  ? 360 THR F CG2 1 
ATOM   2088 N N   . PRO A 1 290 ? 136.420 142.208 143.939 1.00 16.58  ? 361 PRO F N   1 
ATOM   2089 C CA  . PRO A 1 290 ? 135.654 143.452 144.080 1.00 16.58  ? 361 PRO F CA  1 
ATOM   2090 C C   . PRO A 1 290 ? 134.261 143.325 143.481 1.00 16.58  ? 361 PRO F C   1 
ATOM   2091 O O   . PRO A 1 290 ? 134.063 142.681 142.449 1.00 16.58  ? 361 PRO F O   1 
ATOM   2092 C CB  . PRO A 1 290 ? 136.502 144.479 143.320 1.00 16.58  ? 361 PRO F CB  1 
ATOM   2093 C CG  . PRO A 1 290 ? 137.879 143.896 143.298 1.00 16.58  ? 361 PRO F CG  1 
ATOM   2094 C CD  . PRO A 1 290 ? 137.683 142.413 143.212 1.00 16.58  ? 361 PRO F CD  1 
ATOM   2095 N N   . LEU A 1 291 ? 133.292 143.952 144.144 1.00 21.78  ? 362 LEU F N   1 
ATOM   2096 C CA  . LEU A 1 291 ? 131.909 143.962 143.696 1.00 21.78  ? 362 LEU F CA  1 
ATOM   2097 C C   . LEU A 1 291 ? 131.366 145.381 143.761 1.00 21.78  ? 362 LEU F C   1 
ATOM   2098 O O   . LEU A 1 291 ? 131.745 146.169 144.631 1.00 21.78  ? 362 LEU F O   1 
ATOM   2099 C CB  . LEU A 1 291 ? 131.032 143.027 144.543 1.00 21.78  ? 362 LEU F CB  1 
ATOM   2100 C CG  . LEU A 1 291 ? 131.366 141.535 144.490 1.00 21.78  ? 362 LEU F CG  1 
ATOM   2101 C CD1 . LEU A 1 291 ? 130.446 140.749 145.411 1.00 21.78  ? 362 LEU F CD1 1 
ATOM   2102 C CD2 . LEU A 1 291 ? 131.274 141.014 143.065 1.00 21.78  ? 362 LEU F CD2 1 
ATOM   2103 N N   . LYS A 1 292 ? 130.469 145.699 142.831 1.00 31.59  ? 363 LYS F N   1 
ATOM   2104 C CA  . LYS A 1 292 ? 129.887 147.035 142.758 1.00 31.59  ? 363 LYS F CA  1 
ATOM   2105 C C   . LYS A 1 292 ? 128.896 147.222 143.900 1.00 31.59  ? 363 LYS F C   1 
ATOM   2106 O O   . LYS A 1 292 ? 127.837 146.587 143.925 1.00 31.59  ? 363 LYS F O   1 
ATOM   2107 C CB  . LYS A 1 292 ? 129.210 147.243 141.406 1.00 31.59  ? 363 LYS F CB  1 
ATOM   2108 C CG  . LYS A 1 292 ? 128.566 148.610 141.240 1.00 31.59  ? 363 LYS F CG  1 
ATOM   2109 C CD  . LYS A 1 292 ? 129.590 149.726 141.378 1.00 31.59  ? 363 LYS F CD  1 
ATOM   2110 C CE  . LYS A 1 292 ? 130.642 149.653 140.283 1.00 31.59  ? 363 LYS F CE  1 
ATOM   2111 N NZ  . LYS A 1 292 ? 130.043 149.785 138.927 1.00 31.59  ? 363 LYS F NZ  1 
ATOM   2112 N N   . SER A 1 293 ? 129.240 148.090 144.848 1.00 36.71  ? 364 SER F N   1 
ATOM   2113 C CA  . SER A 1 293 ? 128.363 148.359 145.977 1.00 36.71  ? 364 SER F CA  1 
ATOM   2114 C C   . SER A 1 293 ? 127.102 149.085 145.520 1.00 36.71  ? 364 SER F C   1 
ATOM   2115 O O   . SER A 1 293 ? 127.115 149.862 144.562 1.00 36.71  ? 364 SER F O   1 
ATOM   2116 C CB  . SER A 1 293 ? 129.091 149.189 147.033 1.00 36.71  ? 364 SER F CB  1 
ATOM   2117 O OG  . SER A 1 293 ? 128.247 149.460 148.139 1.00 36.71  ? 364 SER F OG  1 
ATOM   2118 N N   . ASN A 1 294 ? 125.999 148.821 146.223 1.00 44.43  ? 365 ASN F N   1 
ATOM   2119 C CA  . ASN A 1 294 ? 124.724 149.447 145.897 1.00 44.43  ? 365 ASN F CA  1 
ATOM   2120 C C   . ASN A 1 294 ? 124.680 150.926 146.257 1.00 44.43  ? 365 ASN F C   1 
ATOM   2121 O O   . ASN A 1 294 ? 123.740 151.615 145.846 1.00 44.43  ? 365 ASN F O   1 
ATOM   2122 C CB  . ASN A 1 294 ? 123.584 148.710 146.601 1.00 44.43  ? 365 ASN F CB  1 
ATOM   2123 C CG  . ASN A 1 294 ? 123.499 147.250 146.201 1.00 44.43  ? 365 ASN F CG  1 
ATOM   2124 O OD1 . ASN A 1 294 ? 124.472 146.668 145.722 1.00 44.43  ? 365 ASN F OD1 1 
ATOM   2125 N ND2 . ASN A 1 294 ? 122.330 146.650 146.395 1.00 44.43  ? 365 ASN F ND2 1 
ATOM   2126 N N   . GLY A 1 295 ? 125.659 151.427 147.007 1.00 48.42  ? 366 GLY F N   1 
ATOM   2127 C CA  . GLY A 1 295 ? 125.662 152.825 147.376 1.00 48.42  ? 366 GLY F CA  1 
ATOM   2128 C C   . GLY A 1 295 ? 125.981 153.735 146.205 1.00 48.42  ? 366 GLY F C   1 
ATOM   2129 O O   . GLY A 1 295 ? 126.467 153.312 145.156 1.00 48.42  ? 366 GLY F O   1 
ATOM   2130 N N   . SER A 1 296 ? 125.695 155.023 146.399 1.00 55.94  ? 367 SER F N   1 
ATOM   2131 C CA  . SER A 1 296 ? 125.926 156.024 145.366 1.00 55.94  ? 367 SER F CA  1 
ATOM   2132 C C   . SER A 1 296 ? 127.397 156.379 145.195 1.00 55.94  ? 367 SER F C   1 
ATOM   2133 O O   . SER A 1 296 ? 127.742 157.058 144.221 1.00 55.94  ? 367 SER F O   1 
ATOM   2134 C CB  . SER A 1 296 ? 125.127 157.292 145.676 1.00 55.94  ? 367 SER F CB  1 
ATOM   2135 O OG  . SER A 1 296 ? 125.341 158.284 144.687 1.00 55.94  ? 367 SER F OG  1 
ATOM   2136 N N   . ASN A 1 297 ? 128.267 155.943 146.108 1.00 51.48  ? 368 ASN F N   1 
ATOM   2137 C CA  . ASN A 1 297 ? 129.688 156.254 146.009 1.00 51.48  ? 368 ASN F CA  1 
ATOM   2138 C C   . ASN A 1 297 ? 130.383 155.502 144.881 1.00 51.48  ? 368 ASN F C   1 
ATOM   2139 O O   . ASN A 1 297 ? 131.531 155.833 144.563 1.00 51.48  ? 368 ASN F O   1 
ATOM   2140 C CB  . ASN A 1 297 ? 130.384 155.947 147.336 1.00 51.48  ? 368 ASN F CB  1 
ATOM   2141 C CG  . ASN A 1 297 ? 129.817 156.749 148.491 1.00 51.48  ? 368 ASN F CG  1 
ATOM   2142 O OD1 . ASN A 1 297 ? 129.339 157.868 148.309 1.00 51.48  ? 368 ASN F OD1 1 
ATOM   2143 N ND2 . ASN A 1 297 ? 129.868 156.178 149.689 1.00 51.48  ? 368 ASN F ND2 1 
ATOM   2144 N N   . GLN A 1 298 ? 129.725 154.505 144.283 1.00 42.28  ? 369 GLN F N   1 
ATOM   2145 C CA  . GLN A 1 298 ? 130.296 153.703 143.199 1.00 42.28  ? 369 GLN F CA  1 
ATOM   2146 C C   . GLN A 1 298 ? 131.586 153.009 143.626 1.00 42.28  ? 369 GLN F C   1 
ATOM   2147 O O   . GLN A 1 298 ? 132.469 152.753 142.804 1.00 42.28  ? 369 GLN F O   1 
ATOM   2148 C CB  . GLN A 1 298 ? 130.533 154.547 141.942 1.00 42.28  ? 369 GLN F CB  1 
ATOM   2149 C CG  . GLN A 1 298 ? 129.259 154.984 141.238 1.00 42.28  ? 369 GLN F CG  1 
ATOM   2150 C CD  . GLN A 1 298 ? 128.522 153.826 140.594 1.00 42.28  ? 369 GLN F CD  1 
ATOM   2151 O OE1 . GLN A 1 298 ? 129.117 152.795 140.279 1.00 42.28  ? 369 GLN F OE1 1 
ATOM   2152 N NE2 . GLN A 1 298 ? 127.219 153.989 140.398 1.00 42.28  ? 369 GLN F NE2 1 
ATOM   2153 N N   . GLY A 1 299 ? 131.705 152.698 144.918 1.00 29.73  ? 370 GLY F N   1 
ATOM   2154 C CA  . GLY A 1 299 ? 132.872 152.020 145.437 1.00 29.73  ? 370 GLY F CA  1 
ATOM   2155 C C   . GLY A 1 299 ? 132.732 150.509 145.398 1.00 29.73  ? 370 GLY F C   1 
ATOM   2156 O O   . GLY A 1 299 ? 131.722 149.952 144.969 1.00 29.73  ? 370 GLY F O   1 
ATOM   2157 N N   . PHE A 1 300 ? 133.783 149.841 145.862 1.00 22.09  ? 371 PHE F N   1 
ATOM   2158 C CA  . PHE A 1 300 ? 133.829 148.389 145.937 1.00 22.09  ? 371 PHE F CA  1 
ATOM   2159 C C   . PHE A 1 300 ? 134.060 147.965 147.379 1.00 22.09  ? 371 PHE F C   1 
ATOM   2160 O O   . PHE A 1 300 ? 134.846 148.586 148.101 1.00 22.09  ? 371 PHE F O   1 
ATOM   2161 C CB  . PHE A 1 300 ? 134.935 147.819 145.041 1.00 22.09  ? 371 PHE F CB  1 
ATOM   2162 C CG  . PHE A 1 300 ? 134.774 148.160 143.586 1.00 22.09  ? 371 PHE F CG  1 
ATOM   2163 C CD1 . PHE A 1 300 ? 134.046 147.337 142.744 1.00 22.09  ? 371 PHE F CD1 1 
ATOM   2164 C CD2 . PHE A 1 300 ? 135.355 149.302 143.060 1.00 22.09  ? 371 PHE F CD2 1 
ATOM   2165 C CE1 . PHE A 1 300 ? 133.897 147.647 141.406 1.00 22.09  ? 371 PHE F CE1 1 
ATOM   2166 C CE2 . PHE A 1 300 ? 135.210 149.618 141.723 1.00 22.09  ? 371 PHE F CE2 1 
ATOM   2167 C CZ  . PHE A 1 300 ? 134.481 148.789 140.894 1.00 22.09  ? 371 PHE F CZ  1 
ATOM   2168 N N   . PHE A 1 301 ? 133.366 146.913 147.800 1.00 21.45  ? 372 PHE F N   1 
ATOM   2169 C CA  . PHE A 1 301 ? 133.520 146.352 149.135 1.00 21.45  ? 372 PHE F CA  1 
ATOM   2170 C C   . PHE A 1 301 ? 134.245 145.017 149.033 1.00 21.45  ? 372 PHE F C   1 
ATOM   2171 O O   . PHE A 1 301 ? 133.842 144.143 148.258 1.00 21.45  ? 372 PHE F O   1 
ATOM   2172 C CB  . PHE A 1 301 ? 132.163 146.183 149.827 1.00 21.45  ? 372 PHE F CB  1 
ATOM   2173 C CG  . PHE A 1 301 ? 131.208 145.281 149.094 1.00 21.45  ? 372 PHE F CG  1 
ATOM   2174 C CD1 . PHE A 1 301 ? 130.466 145.755 148.023 1.00 21.45  ? 372 PHE F CD1 1 
ATOM   2175 C CD2 . PHE A 1 301 ? 131.040 143.962 149.485 1.00 21.45  ? 372 PHE F CD2 1 
ATOM   2176 C CE1 . PHE A 1 301 ? 129.587 144.928 147.351 1.00 21.45  ? 372 PHE F CE1 1 
ATOM   2177 C CE2 . PHE A 1 301 ? 130.163 143.132 148.817 1.00 21.45  ? 372 PHE F CE2 1 
ATOM   2178 C CZ  . PHE A 1 301 ? 129.436 143.616 147.749 1.00 21.45  ? 372 PHE F CZ  1 
ATOM   2179 N N   . ILE A 1 302 ? 135.325 144.872 149.797 1.00 18.21  ? 373 ILE F N   1 
ATOM   2180 C CA  . ILE A 1 302 ? 136.114 143.647 149.823 1.00 18.21  ? 373 ILE F CA  1 
ATOM   2181 C C   . ILE A 1 302 ? 136.394 143.282 151.274 1.00 18.21  ? 373 ILE F C   1 
ATOM   2182 O O   . ILE A 1 302 ? 136.776 144.143 152.076 1.00 18.21  ? 373 ILE F O   1 
ATOM   2183 C CB  . ILE A 1 302 ? 137.427 143.789 149.029 1.00 18.21  ? 373 ILE F CB  1 
ATOM   2184 C CG1 . ILE A 1 302 ? 138.127 145.105 149.368 1.00 18.21  ? 373 ILE F CG1 1 
ATOM   2185 C CG2 . ILE A 1 302 ? 137.159 143.693 147.535 1.00 18.21  ? 373 ILE F CG2 1 
ATOM   2186 C CD1 . ILE A 1 302 ? 139.414 145.327 148.604 1.00 18.21  ? 373 ILE F CD1 1 
ATOM   2187 N N   . PHE A 1 303 ? 136.197 142.010 151.607 1.00 18.11  ? 374 PHE F N   1 
ATOM   2188 C CA  . PHE A 1 303 ? 136.417 141.482 152.951 1.00 18.11  ? 374 PHE F CA  1 
ATOM   2189 C C   . PHE A 1 303 ? 137.628 140.553 152.896 1.00 18.11  ? 374 PHE F C   1 
ATOM   2190 O O   . PHE A 1 303 ? 137.505 139.370 152.574 1.00 18.11  ? 374 PHE F O   1 
ATOM   2191 C CB  . PHE A 1 303 ? 135.181 140.743 153.467 1.00 18.11  ? 374 PHE F CB  1 
ATOM   2192 C CG  . PHE A 1 303 ? 133.959 141.608 153.597 1.00 18.11  ? 374 PHE F CG  1 
ATOM   2193 C CD1 . PHE A 1 303 ? 133.133 141.834 152.509 1.00 18.11  ? 374 PHE F CD1 1 
ATOM   2194 C CD2 . PHE A 1 303 ? 133.626 142.179 154.815 1.00 18.11  ? 374 PHE F CD2 1 
ATOM   2195 C CE1 . PHE A 1 303 ? 132.005 142.624 152.628 1.00 18.11  ? 374 PHE F CE1 1 
ATOM   2196 C CE2 . PHE A 1 303 ? 132.499 142.968 154.941 1.00 18.11  ? 374 PHE F CE2 1 
ATOM   2197 C CZ  . PHE A 1 303 ? 131.687 143.190 153.846 1.00 18.11  ? 374 PHE F CZ  1 
ATOM   2198 N N   . SER A 1 304 ? 138.801 141.094 153.212 1.00 17.44  ? 375 SER F N   1 
ATOM   2199 C CA  . SER A 1 304 ? 140.001 140.274 153.303 1.00 17.44  ? 375 SER F CA  1 
ATOM   2200 C C   . SER A 1 304 ? 139.958 139.460 154.590 1.00 17.44  ? 375 SER F C   1 
ATOM   2201 O O   . SER A 1 304 ? 139.900 140.025 155.688 1.00 17.44  ? 375 SER F O   1 
ATOM   2202 C CB  . SER A 1 304 ? 141.249 141.153 153.259 1.00 17.44  ? 375 SER F CB  1 
ATOM   2203 O OG  . SER A 1 304 ? 142.427 140.371 153.352 1.00 17.44  ? 375 SER F OG  1 
ATOM   2204 N N   . ARG A 1 305 ? 139.975 138.137 154.457 1.00 21.19  ? 376 ARG F N   1 
ATOM   2205 C CA  . ARG A 1 305 ? 139.872 137.225 155.589 1.00 21.19  ? 376 ARG F CA  1 
ATOM   2206 C C   . ARG A 1 305 ? 141.216 136.540 155.797 1.00 21.19  ? 376 ARG F C   1 
ATOM   2207 O O   . ARG A 1 305 ? 141.721 135.868 154.891 1.00 21.19  ? 376 ARG F O   1 
ATOM   2208 C CB  . ARG A 1 305 ? 138.768 136.194 155.356 1.00 21.19  ? 376 ARG F CB  1 
ATOM   2209 C CG  . ARG A 1 305 ? 138.695 135.099 156.407 1.00 21.19  ? 376 ARG F CG  1 
ATOM   2210 C CD  . ARG A 1 305 ? 137.507 134.183 156.154 1.00 21.19  ? 376 ARG F CD  1 
ATOM   2211 N NE  . ARG A 1 305 ? 137.504 133.023 157.037 1.00 21.19  ? 376 ARG F NE  1 
ATOM   2212 C CZ  . ARG A 1 305 ? 138.030 131.845 156.727 1.00 21.19  ? 376 ARG F CZ  1 
ATOM   2213 N NH1 . ARG A 1 305 ? 138.615 131.635 155.559 1.00 21.19  ? 376 ARG F NH1 1 
ATOM   2214 N NH2 . ARG A 1 305 ? 137.964 130.853 157.609 1.00 21.19  ? 376 ARG F NH2 1 
ATOM   2215 N N   . LEU A 1 306 ? 141.787 136.712 156.985 1.00 23.56  ? 377 LEU F N   1 
ATOM   2216 C CA  . LEU A 1 306 ? 143.050 136.087 157.359 1.00 23.56  ? 377 LEU F CA  1 
ATOM   2217 C C   . LEU A 1 306 ? 142.782 135.044 158.433 1.00 23.56  ? 377 LEU F C   1 
ATOM   2218 O O   . LEU A 1 306 ? 142.324 135.382 159.530 1.00 23.56  ? 377 LEU F O   1 
ATOM   2219 C CB  . LEU A 1 306 ? 144.053 137.126 157.859 1.00 23.56  ? 377 LEU F CB  1 
ATOM   2220 C CG  . LEU A 1 306 ? 145.334 136.560 158.478 1.00 23.56  ? 377 LEU F CG  1 
ATOM   2221 C CD1 . LEU A 1 306 ? 146.133 135.773 157.450 1.00 23.56  ? 377 LEU F CD1 1 
ATOM   2222 C CD2 . LEU A 1 306 ? 146.178 137.666 159.090 1.00 23.56  ? 377 LEU F CD2 1 
ATOM   2223 N N   . GLU A 1 307 ? 143.071 133.784 158.120 1.00 31.87  ? 378 GLU F N   1 
ATOM   2224 C CA  . GLU A 1 307 ? 142.871 132.685 159.055 1.00 31.87  ? 378 GLU F CA  1 
ATOM   2225 C C   . GLU A 1 307 ? 144.151 132.461 159.851 1.00 31.87  ? 378 GLU F C   1 
ATOM   2226 O O   . GLU A 1 307 ? 145.192 132.119 159.280 1.00 31.87  ? 378 GLU F O   1 
ATOM   2227 C CB  . GLU A 1 307 ? 142.470 131.410 158.314 1.00 31.87  ? 378 GLU F CB  1 
ATOM   2228 C CG  . GLU A 1 307 ? 142.390 130.182 159.204 1.00 31.87  ? 378 GLU F CG  1 
ATOM   2229 C CD  . GLU A 1 307 ? 142.072 128.920 158.430 1.00 31.87  ? 378 GLU F CD  1 
ATOM   2230 O OE1 . GLU A 1 307 ? 141.555 129.028 157.298 1.00 31.87  ? 378 GLU F OE1 1 
ATOM   2231 O OE2 . GLU A 1 307 ? 142.345 127.819 158.952 1.00 31.87  ? 378 GLU F OE2 1 
ATOM   2232 N N   . VAL A 1 308 ? 144.071 132.654 161.165 1.00 32.64  ? 379 VAL F N   1 
ATOM   2233 C CA  . VAL A 1 308 ? 145.200 132.453 162.064 1.00 32.64  ? 379 VAL F CA  1 
ATOM   2234 C C   . VAL A 1 308 ? 144.769 131.522 163.188 1.00 32.64  ? 379 VAL F C   1 
ATOM   2235 O O   . VAL A 1 308 ? 143.654 131.633 163.710 1.00 32.64  ? 379 VAL F O   1 
ATOM   2236 C CB  . VAL A 1 308 ? 145.734 133.787 162.627 1.00 32.64  ? 379 VAL F CB  1 
ATOM   2237 C CG1 . VAL A 1 308 ? 146.456 134.568 161.540 1.00 32.64  ? 379 VAL F CG1 1 
ATOM   2238 C CG2 . VAL A 1 308 ? 144.601 134.613 163.211 1.00 32.64  ? 379 VAL F CG2 1 
ATOM   2239 N N   . ALA A 1 309 ? 145.655 130.599 163.555 1.00 43.05  ? 380 ALA F N   1 
ATOM   2240 C CA  . ALA A 1 309 ? 145.357 129.618 164.584 1.00 43.05  ? 380 ALA F CA  1 
ATOM   2241 C C   . ALA A 1 309 ? 145.437 130.256 165.970 1.00 43.05  ? 380 ALA F C   1 
ATOM   2242 O O   . ALA A 1 309 ? 145.712 131.450 166.124 1.00 43.05  ? 380 ALA F O   1 
ATOM   2243 C CB  . ALA A 1 309 ? 146.305 128.427 164.471 1.00 43.05  ? 380 ALA F CB  1 
ATOM   2244 N N   . LYS A 1 310 ? 145.186 129.441 166.996 1.00 46.01  ? 381 LYS F N   1 
ATOM   2245 C CA  . LYS A 1 310 ? 145.216 129.937 168.368 1.00 46.01  ? 381 LYS F CA  1 
ATOM   2246 C C   . LYS A 1 310 ? 146.619 130.374 168.774 1.00 46.01  ? 381 LYS F C   1 
ATOM   2247 O O   . LYS A 1 310 ? 146.781 131.378 169.478 1.00 46.01  ? 381 LYS F O   1 
ATOM   2248 C CB  . LYS A 1 310 ? 144.691 128.864 169.322 1.00 46.01  ? 381 LYS F CB  1 
ATOM   2249 C CG  . LYS A 1 310 ? 144.693 129.273 170.786 1.00 46.01  ? 381 LYS F CG  1 
ATOM   2250 C CD  . LYS A 1 310 ? 144.190 128.146 171.674 1.00 46.01  ? 381 LYS F CD  1 
ATOM   2251 C CE  . LYS A 1 310 ? 144.212 128.547 173.140 1.00 46.01  ? 381 LYS F CE  1 
ATOM   2252 N NZ  . LYS A 1 310 ? 143.355 129.736 173.403 1.00 46.01  ? 381 LYS F NZ  1 
ATOM   2253 N N   . THR A 1 311 ? 147.642 129.630 168.345 1.00 51.46  ? 382 THR F N   1 
ATOM   2254 C CA  . THR A 1 311 ? 149.009 129.937 168.757 1.00 51.46  ? 382 THR F CA  1 
ATOM   2255 C C   . THR A 1 311 ? 149.444 131.313 168.267 1.00 51.46  ? 382 THR F C   1 
ATOM   2256 O O   . THR A 1 311 ? 150.064 132.078 169.016 1.00 51.46  ? 382 THR F O   1 
ATOM   2257 C CB  . THR A 1 311 ? 149.965 128.860 168.242 1.00 51.46  ? 382 THR F CB  1 
ATOM   2258 O OG1 . THR A 1 311 ? 149.554 127.578 168.734 1.00 51.46  ? 382 THR F OG1 1 
ATOM   2259 C CG2 . THR A 1 311 ? 151.387 129.141 168.706 1.00 51.46  ? 382 THR F CG2 1 
ATOM   2260 N N   . LEU A 1 312 ? 149.127 131.648 167.014 1.00 51.96  ? 383 LEU F N   1 
ATOM   2261 C CA  . LEU A 1 312 ? 149.523 132.945 166.474 1.00 51.96  ? 383 LEU F CA  1 
ATOM   2262 C C   . LEU A 1 312 ? 148.831 134.088 167.205 1.00 51.96  ? 383 LEU F C   1 
ATOM   2263 O O   . LEU A 1 312 ? 149.457 135.110 167.511 1.00 51.96  ? 383 LEU F O   1 
ATOM   2264 C CB  . LEU A 1 312 ? 149.217 133.003 164.977 1.00 51.96  ? 383 LEU F CB  1 
ATOM   2265 C CG  . LEU A 1 312 ? 149.916 131.968 164.095 1.00 51.96  ? 383 LEU F CG  1 
ATOM   2266 C CD1 . LEU A 1 312 ? 149.501 132.132 162.641 1.00 51.96  ? 383 LEU F CD1 1 
ATOM   2267 C CD2 . LEU A 1 312 ? 151.427 132.070 164.239 1.00 51.96  ? 383 LEU F CD2 1 
ATOM   2268 N N   . TRP A 1 313 ? 147.537 133.936 167.495 1.00 46.23  ? 384 TRP F N   1 
ATOM   2269 C CA  . TRP A 1 313 ? 146.776 135.020 168.105 1.00 46.23  ? 384 TRP F CA  1 
ATOM   2270 C C   . TRP A 1 313 ? 147.066 135.175 169.593 1.00 46.23  ? 384 TRP F C   1 
ATOM   2271 O O   . TRP A 1 313 ? 146.960 136.286 170.125 1.00 46.23  ? 384 TRP F O   1 
ATOM   2272 C CB  . TRP A 1 313 ? 145.279 134.797 167.883 1.00 46.23  ? 384 TRP F CB  1 
ATOM   2273 C CG  . TRP A 1 313 ? 144.426 135.949 168.317 1.00 46.23  ? 384 TRP F CG  1 
ATOM   2274 C CD1 . TRP A 1 313 ? 143.626 136.007 169.420 1.00 46.23  ? 384 TRP F CD1 1 
ATOM   2275 C CD2 . TRP A 1 313 ? 144.294 137.214 167.659 1.00 46.23  ? 384 TRP F CD2 1 
ATOM   2276 N NE1 . TRP A 1 313 ? 142.999 137.228 169.487 1.00 46.23  ? 384 TRP F NE1 1 
ATOM   2277 C CE2 . TRP A 1 313 ? 143.393 137.988 168.417 1.00 46.23  ? 384 TRP F CE2 1 
ATOM   2278 C CE3 . TRP A 1 313 ? 144.849 137.768 166.501 1.00 46.23  ? 384 TRP F CE3 1 
ATOM   2279 C CZ2 . TRP A 1 313 ? 143.035 139.285 168.056 1.00 46.23  ? 384 TRP F CZ2 1 
ATOM   2280 C CZ3 . TRP A 1 313 ? 144.493 139.055 166.145 1.00 46.23  ? 384 TRP F CZ3 1 
ATOM   2281 C CH2 . TRP A 1 313 ? 143.594 139.799 166.919 1.00 46.23  ? 384 TRP F CH2 1 
ATOM   2282 N N   . THR A 1 314 ? 147.431 134.093 170.279 1.00 55.25  ? 385 THR F N   1 
ATOM   2283 C CA  . THR A 1 314 ? 147.639 134.143 171.722 1.00 55.25  ? 385 THR F CA  1 
ATOM   2284 C C   . THR A 1 314 ? 149.023 134.644 172.118 1.00 55.25  ? 385 THR F C   1 
ATOM   2285 O O   . THR A 1 314 ? 149.280 134.807 173.316 1.00 55.25  ? 385 THR F O   1 
ATOM   2286 C CB  . THR A 1 314 ? 147.404 132.761 172.340 1.00 55.25  ? 385 THR F CB  1 
ATOM   2287 O OG1 . THR A 1 314 ? 148.089 131.765 171.569 1.00 55.25  ? 385 THR F OG1 1 
ATOM   2288 C CG2 . THR A 1 314 ? 145.916 132.440 172.382 1.00 55.25  ? 385 THR F CG2 1 
ATOM   2289 N N   . GLN A 1 315 ? 149.915 134.893 171.160 1.00 61.83  ? 386 GLN F N   1 
ATOM   2290 C CA  . GLN A 1 315 ? 151.254 135.382 171.454 1.00 61.83  ? 386 GLN F CA  1 
ATOM   2291 C C   . GLN A 1 315 ? 151.350 136.904 171.416 1.00 61.83  ? 386 GLN F C   1 
ATOM   2292 O O   . GLN A 1 315 ? 152.436 137.439 171.164 1.00 61.83  ? 386 GLN F O   1 
ATOM   2293 C CB  . GLN A 1 315 ? 152.268 134.767 170.486 1.00 61.83  ? 386 GLN F CB  1 
ATOM   2294 C CG  . GLN A 1 315 ? 152.510 133.282 170.704 1.00 61.83  ? 386 GLN F CG  1 
ATOM   2295 C CD  . GLN A 1 315 ? 153.572 132.722 169.779 1.00 61.83  ? 386 GLN F CD  1 
ATOM   2296 O OE1 . GLN A 1 315 ? 154.204 133.460 169.022 1.00 61.83  ? 386 GLN F OE1 1 
ATOM   2297 N NE2 . GLN A 1 315 ? 153.774 131.411 169.835 1.00 61.83  ? 386 GLN F NE2 1 
ATOM   2298 N N   . ARG A 1 316 ? 150.240 137.606 171.661 1.00 67.07  ? 387 ARG F N   1 
ATOM   2299 C CA  . ARG A 1 316 ? 150.211 139.071 171.683 1.00 67.07  ? 387 ARG F CA  1 
ATOM   2300 C C   . ARG A 1 316 ? 150.720 139.664 170.371 1.00 67.07  ? 387 ARG F C   1 
ATOM   2301 O O   . ARG A 1 316 ? 151.440 140.664 170.358 1.00 67.07  ? 387 ARG F O   1 
ATOM   2302 C CB  . ARG A 1 316 ? 151.003 139.621 172.873 1.00 67.07  ? 387 ARG F CB  1 
ATOM   2303 C CG  . ARG A 1 316 ? 150.283 139.506 174.207 1.00 67.07  ? 387 ARG F CG  1 
ATOM   2304 C CD  . ARG A 1 316 ? 149.120 140.481 174.286 1.00 67.07  ? 387 ARG F CD  1 
ATOM   2305 N NE  . ARG A 1 316 ? 148.370 140.346 175.529 1.00 67.07  ? 387 ARG F NE  1 
ATOM   2306 C CZ  . ARG A 1 316 ? 147.284 139.599 175.671 1.00 67.07  ? 387 ARG F CZ  1 
ATOM   2307 N NH1 . ARG A 1 316 ? 146.788 138.901 174.663 1.00 67.07  ? 387 ARG F NH1 1 
ATOM   2308 N NH2 . ARG A 1 316 ? 146.679 139.551 176.855 1.00 67.07  ? 387 ARG F NH2 1 
ATOM   2309 N N   . LYS A 1 317 ? 150.344 139.042 169.257 1.00 55.90  ? 388 LYS F N   1 
ATOM   2310 C CA  . LYS A 1 317 ? 150.720 139.528 167.937 1.00 55.90  ? 388 LYS F CA  1 
ATOM   2311 C C   . LYS A 1 317 ? 149.724 140.580 167.469 1.00 55.90  ? 388 LYS F C   1 
ATOM   2312 O O   . LYS A 1 317 ? 148.508 140.375 167.553 1.00 55.90  ? 388 LYS F O   1 
ATOM   2313 C CB  . LYS A 1 317 ? 150.781 138.380 166.928 1.00 55.90  ? 388 LYS F CB  1 
ATOM   2314 C CG  . LYS A 1 317 ? 151.956 137.435 167.115 1.00 55.90  ? 388 LYS F CG  1 
ATOM   2315 C CD  . LYS A 1 317 ? 152.064 136.470 165.944 1.00 55.90  ? 388 LYS F CD  1 
ATOM   2316 C CE  . LYS A 1 317 ? 153.280 135.568 166.074 1.00 55.90  ? 388 LYS F CE  1 
ATOM   2317 N NZ  . LYS A 1 317 ? 153.196 134.694 167.274 1.00 55.90  ? 388 LYS F NZ  1 
ATOM   2318 N N   . GLN A 1 318 ? 150.241 141.701 166.977 1.00 46.21  ? 389 GLN F N   1 
ATOM   2319 C CA  . GLN A 1 318 ? 149.419 142.759 166.406 1.00 46.21  ? 389 GLN F CA  1 
ATOM   2320 C C   . GLN A 1 318 ? 149.387 142.601 164.892 1.00 46.21  ? 389 GLN F C   1 
ATOM   2321 O O   . GLN A 1 318 ? 150.436 142.464 164.254 1.00 46.21  ? 389 GLN F O   1 
ATOM   2322 C CB  . GLN A 1 318 ? 149.952 144.140 166.794 1.00 46.21  ? 389 GLN F CB  1 
ATOM   2323 C CG  . GLN A 1 318 ? 151.443 144.333 166.560 1.00 46.21  ? 389 GLN F CG  1 
ATOM   2324 C CD  . GLN A 1 318 ? 151.915 145.726 166.924 1.00 46.21  ? 389 GLN F CD  1 
ATOM   2325 O OE1 . GLN A 1 318 ? 151.130 146.564 167.370 1.00 46.21  ? 389 GLN F OE1 1 
ATOM   2326 N NE2 . GLN A 1 318 ? 153.204 145.982 166.736 1.00 46.21  ? 389 GLN F NE2 1 
ATOM   2327 N N   . PHE A 1 319 ? 148.185 142.609 164.324 1.00 34.65  ? 390 PHE F N   1 
ATOM   2328 C CA  . PHE A 1 319 ? 147.993 142.404 162.895 1.00 34.65  ? 390 PHE F CA  1 
ATOM   2329 C C   . PHE A 1 319 ? 147.568 143.712 162.245 1.00 34.65  ? 390 PHE F C   1 
ATOM   2330 O O   . PHE A 1 319 ? 146.648 144.380 162.727 1.00 34.65  ? 390 PHE F O   1 
ATOM   2331 C CB  . PHE A 1 319 ? 146.955 141.310 162.631 1.00 34.65  ? 390 PHE F CB  1 
ATOM   2332 C CG  . PHE A 1 319 ? 147.454 139.922 162.918 1.00 34.65  ? 390 PHE F CG  1 
ATOM   2333 C CD1 . PHE A 1 319 ? 148.812 139.645 162.912 1.00 34.65  ? 390 PHE F CD1 1 
ATOM   2334 C CD2 . PHE A 1 319 ? 146.568 138.894 163.191 1.00 34.65  ? 390 PHE F CD2 1 
ATOM   2335 C CE1 . PHE A 1 319 ? 149.276 138.370 163.174 1.00 34.65  ? 390 PHE F CE1 1 
ATOM   2336 C CE2 . PHE A 1 319 ? 147.026 137.616 163.454 1.00 34.65  ? 390 PHE F CE2 1 
ATOM   2337 C CZ  . PHE A 1 319 ? 148.381 137.354 163.445 1.00 34.65  ? 390 PHE F CZ  1 
ATOM   2338 N N   . THR A 1 320 ? 148.240 144.075 161.156 1.00 26.70  ? 391 THR F N   1 
ATOM   2339 C CA  . THR A 1 320 ? 147.990 145.329 160.459 1.00 26.70  ? 391 THR F CA  1 
ATOM   2340 C C   . THR A 1 320 ? 147.458 145.031 159.065 1.00 26.70  ? 391 THR F C   1 
ATOM   2341 O O   . THR A 1 320 ? 148.105 144.322 158.287 1.00 26.70  ? 391 THR F O   1 
ATOM   2342 C CB  . THR A 1 320 ? 149.262 146.174 160.375 1.00 26.70  ? 391 THR F CB  1 
ATOM   2343 O OG1 . THR A 1 320 ? 149.723 146.480 161.697 1.00 26.70  ? 391 THR F OG1 1 
ATOM   2344 C CG2 . THR A 1 320 ? 148.992 147.469 159.626 1.00 26.70  ? 391 THR F CG2 1 
ATOM   2345 N N   . CYS A 1 321 ? 146.282 145.569 158.758 1.00 23.67  ? 392 CYS F N   1 
ATOM   2346 C CA  . CYS A 1 321 ? 145.739 145.543 157.407 1.00 23.67  ? 392 CYS F CA  1 
ATOM   2347 C C   . CYS A 1 321 ? 146.259 146.769 156.666 1.00 23.67  ? 392 CYS F C   1 
ATOM   2348 O O   . CYS A 1 321 ? 146.033 147.905 157.103 1.00 23.67  ? 392 CYS F O   1 
ATOM   2349 C CB  . CYS A 1 321 ? 144.210 145.524 157.438 1.00 23.67  ? 392 CYS F CB  1 
ATOM   2350 S SG  . CYS A 1 321 ? 143.411 145.288 155.828 1.00 23.67  ? 392 CYS F SG  1 
ATOM   2351 N N   . GLN A 1 322 ? 146.969 146.539 155.565 1.00 19.02  ? 393 GLN F N   1 
ATOM   2352 C CA  . GLN A 1 322 ? 147.581 147.599 154.776 1.00 19.02  ? 393 GLN F CA  1 
ATOM   2353 C C   . GLN A 1 322 ? 146.889 147.683 153.423 1.00 19.02  ? 393 GLN F C   1 
ATOM   2354 O O   . GLN A 1 322 ? 146.705 146.663 152.748 1.00 19.02  ? 393 GLN F O   1 
ATOM   2355 C CB  . GLN A 1 322 ? 149.080 147.353 154.592 1.00 19.02  ? 393 GLN F CB  1 
ATOM   2356 C CG  . GLN A 1 322 ? 149.759 148.346 153.662 1.00 19.02  ? 393 GLN F CG  1 
ATOM   2357 C CD  . GLN A 1 322 ? 151.256 148.127 153.563 1.00 19.02  ? 393 GLN F CD  1 
ATOM   2358 O OE1 . GLN A 1 322 ? 151.863 148.371 152.520 1.00 19.02  ? 393 GLN F OE1 1 
ATOM   2359 N NE2 . GLN A 1 322 ? 151.861 147.672 154.653 1.00 19.02  ? 393 GLN F NE2 1 
ATOM   2360 N N   . VAL A 1 323 ? 146.511 148.897 153.035 1.00 16.05  ? 394 VAL F N   1 
ATOM   2361 C CA  . VAL A 1 323 ? 145.769 149.152 151.809 1.00 16.05  ? 394 VAL F CA  1 
ATOM   2362 C C   . VAL A 1 323 ? 146.563 150.137 150.965 1.00 16.05  ? 394 VAL F C   1 
ATOM   2363 O O   . VAL A 1 323 ? 146.969 151.198 151.455 1.00 16.05  ? 394 VAL F O   1 
ATOM   2364 C CB  . VAL A 1 323 ? 144.362 149.697 152.107 1.00 16.05  ? 394 VAL F CB  1 
ATOM   2365 C CG1 . VAL A 1 323 ? 143.613 149.973 150.817 1.00 16.05  ? 394 VAL F CG1 1 
ATOM   2366 C CG2 . VAL A 1 323 ? 143.598 148.718 152.979 1.00 16.05  ? 394 VAL F CG2 1 
ATOM   2367 N N   . ILE A 1 324 ? 146.784 149.782 149.702 1.00 14.43  ? 395 ILE F N   1 
ATOM   2368 C CA  . ILE A 1 324 ? 147.484 150.628 148.744 1.00 14.43  ? 395 ILE F CA  1 
ATOM   2369 C C   . ILE A 1 324 ? 146.509 150.962 147.625 1.00 14.43  ? 395 ILE F C   1 
ATOM   2370 O O   . ILE A 1 324 ? 145.989 150.058 146.956 1.00 14.43  ? 395 ILE F O   1 
ATOM   2371 C CB  . ILE A 1 324 ? 148.747 149.951 148.188 1.00 14.43  ? 395 ILE F CB  1 
ATOM   2372 C CG1 . ILE A 1 324 ? 149.756 149.677 149.308 1.00 14.43  ? 395 ILE F CG1 1 
ATOM   2373 C CG2 . ILE A 1 324 ? 149.376 150.809 147.100 1.00 14.43  ? 395 ILE F CG2 1 
ATOM   2374 C CD1 . ILE A 1 324 ? 149.630 148.303 149.937 1.00 14.43  ? 395 ILE F CD1 1 
ATOM   2375 N N   . HIS A 1 325 ? 146.263 152.255 147.425 1.00 14.32  ? 396 HIS F N   1 
ATOM   2376 C CA  . HIS A 1 325 ? 145.346 152.722 146.397 1.00 14.32  ? 396 HIS F CA  1 
ATOM   2377 C C   . HIS A 1 325 ? 145.793 154.104 145.942 1.00 14.32  ? 396 HIS F C   1 
ATOM   2378 O O   . HIS A 1 325 ? 146.472 154.829 146.673 1.00 14.32  ? 396 HIS F O   1 
ATOM   2379 C CB  . HIS A 1 325 ? 143.901 152.756 146.911 1.00 14.32  ? 396 HIS F CB  1 
ATOM   2380 C CG  . HIS A 1 325 ? 142.875 152.886 145.829 1.00 14.32  ? 396 HIS F CG  1 
ATOM   2381 N ND1 . HIS A 1 325 ? 142.429 154.106 145.368 1.00 14.32  ? 396 HIS F ND1 1 
ATOM   2382 C CD2 . HIS A 1 325 ? 142.203 151.948 145.121 1.00 14.32  ? 396 HIS F CD2 1 
ATOM   2383 C CE1 . HIS A 1 325 ? 141.530 153.914 144.420 1.00 14.32  ? 396 HIS F CE1 1 
ATOM   2384 N NE2 . HIS A 1 325 ? 141.374 152.614 144.251 1.00 14.32  ? 396 HIS F NE2 1 
ATOM   2385 N N   . GLU A 1 326 ? 145.402 154.463 144.718 1.00 16.01  ? 397 GLU F N   1 
ATOM   2386 C CA  . GLU A 1 326 ? 145.816 155.739 144.146 1.00 16.01  ? 397 GLU F CA  1 
ATOM   2387 C C   . GLU A 1 326 ? 145.067 156.927 144.735 1.00 16.01  ? 397 GLU F C   1 
ATOM   2388 O O   . GLU A 1 326 ? 145.594 158.044 144.714 1.00 16.01  ? 397 GLU F O   1 
ATOM   2389 C CB  . GLU A 1 326 ? 145.636 155.720 142.626 1.00 16.01  ? 397 GLU F CB  1 
ATOM   2390 C CG  . GLU A 1 326 ? 144.201 155.553 142.159 1.00 16.01  ? 397 GLU F CG  1 
ATOM   2391 C CD  . GLU A 1 326 ? 144.093 155.475 140.648 1.00 16.01  ? 397 GLU F CD  1 
ATOM   2392 O OE1 . GLU A 1 326 ? 145.080 155.066 140.001 1.00 16.01  ? 397 GLU F OE1 1 
ATOM   2393 O OE2 . GLU A 1 326 ? 143.026 155.829 140.107 1.00 16.01  ? 397 GLU F OE2 1 
ATOM   2394 N N   . ALA A 1 327 ? 143.857 156.717 145.258 1.00 16.54  ? 398 ALA F N   1 
ATOM   2395 C CA  . ALA A 1 327 ? 143.087 157.821 145.818 1.00 16.54  ? 398 ALA F CA  1 
ATOM   2396 C C   . ALA A 1 327 ? 143.628 158.282 147.165 1.00 16.54  ? 398 ALA F C   1 
ATOM   2397 O O   . ALA A 1 327 ? 143.331 159.405 147.585 1.00 16.54  ? 398 ALA F O   1 
ATOM   2398 C CB  . ALA A 1 327 ? 141.618 157.422 145.957 1.00 16.54  ? 398 ALA F CB  1 
ATOM   2399 N N   . LEU A 1 328 ? 144.407 157.448 147.846 1.00 18.45  ? 399 LEU F N   1 
ATOM   2400 C CA  . LEU A 1 328 ? 144.978 157.832 149.128 1.00 18.45  ? 399 LEU F CA  1 
ATOM   2401 C C   . LEU A 1 328 ? 146.092 158.855 148.937 1.00 18.45  ? 399 LEU F C   1 
ATOM   2402 O O   . LEU A 1 328 ? 146.722 158.935 147.879 1.00 18.45  ? 399 LEU F O   1 
ATOM   2403 C CB  . LEU A 1 328 ? 145.519 156.605 149.861 1.00 18.45  ? 399 LEU F CB  1 
ATOM   2404 C CG  . LEU A 1 328 ? 144.486 155.603 150.377 1.00 18.45  ? 399 LEU F CG  1 
ATOM   2405 C CD1 . LEU A 1 328 ? 145.170 154.344 150.882 1.00 18.45  ? 399 LEU F CD1 1 
ATOM   2406 C CD2 . LEU A 1 328 ? 143.642 156.232 151.474 1.00 18.45  ? 399 LEU F CD2 1 
ATOM   2407 N N   . GLN A 1 329 ? 146.330 159.645 149.982 1.00 22.98  ? 400 GLN F N   1 
ATOM   2408 C CA  . GLN A 1 329 ? 147.413 160.616 149.962 1.00 22.98  ? 400 GLN F CA  1 
ATOM   2409 C C   . GLN A 1 329 ? 148.757 159.899 150.084 1.00 22.98  ? 400 GLN F C   1 
ATOM   2410 O O   . GLN A 1 329 ? 148.834 158.676 150.222 1.00 22.98  ? 400 GLN F O   1 
ATOM   2411 C CB  . GLN A 1 329 ? 147.230 161.641 151.080 1.00 22.98  ? 400 GLN F CB  1 
ATOM   2412 C CG  . GLN A 1 329 ? 146.152 162.686 150.811 1.00 22.98  ? 400 GLN F CG  1 
ATOM   2413 C CD  . GLN A 1 329 ? 144.746 162.118 150.870 1.00 22.98  ? 400 GLN F CD  1 
ATOM   2414 O OE1 . GLN A 1 329 ? 144.523 161.032 151.406 1.00 22.98  ? 400 GLN F OE1 1 
ATOM   2415 N NE2 . GLN A 1 329 ? 143.789 162.853 150.316 1.00 22.98  ? 400 GLN F NE2 1 
ATOM   2416 N N   . LYS A 1 330 ? 149.832 160.679 150.031 1.00 23.93  ? 401 LYS F N   1 
ATOM   2417 C CA  . LYS A 1 330 ? 151.167 160.104 150.087 1.00 23.93  ? 401 LYS F CA  1 
ATOM   2418 C C   . LYS A 1 330 ? 151.382 159.406 151.428 1.00 23.93  ? 401 LYS F C   1 
ATOM   2419 O O   . LYS A 1 330 ? 150.928 159.902 152.467 1.00 23.93  ? 401 LYS F O   1 
ATOM   2420 C CB  . LYS A 1 330 ? 152.226 161.190 149.885 1.00 23.93  ? 401 LYS F CB  1 
ATOM   2421 C CG  . LYS A 1 330 ? 151.989 162.076 148.673 1.00 23.93  ? 401 LYS F CG  1 
ATOM   2422 C CD  . LYS A 1 330 ? 151.996 161.272 147.383 1.00 23.93  ? 401 LYS F CD  1 
ATOM   2423 C CE  . LYS A 1 330 ? 151.766 162.169 146.177 1.00 23.93  ? 401 LYS F CE  1 
ATOM   2424 N NZ  . LYS A 1 330 ? 151.795 161.406 144.899 1.00 23.93  ? 401 LYS F NZ  1 
ATOM   2425 N N   . PRO A 1 331 ? 152.069 158.256 151.449 1.00 22.47  ? 402 PRO F N   1 
ATOM   2426 C CA  . PRO A 1 331 ? 152.653 157.535 150.311 1.00 22.47  ? 402 PRO F CA  1 
ATOM   2427 C C   . PRO A 1 331 ? 151.731 156.462 149.737 1.00 22.47  ? 402 PRO F C   1 
ATOM   2428 O O   . PRO A 1 331 ? 152.183 155.355 149.453 1.00 22.47  ? 402 PRO F O   1 
ATOM   2429 C CB  . PRO A 1 331 ? 153.914 156.924 150.928 1.00 22.47  ? 402 PRO F CB  1 
ATOM   2430 C CG  . PRO A 1 331 ? 153.475 156.577 152.327 1.00 22.47  ? 402 PRO F CG  1 
ATOM   2431 C CD  . PRO A 1 331 ? 152.493 157.664 152.732 1.00 22.47  ? 402 PRO F CD  1 
ATOM   2432 N N   . ARG A 1 332 ? 150.443 156.767 149.559 1.00 20.00  ? 403 ARG F N   1 
ATOM   2433 C CA  . ARG A 1 332 ? 149.466 155.821 149.010 1.00 20.00  ? 403 ARG F CA  1 
ATOM   2434 C C   . ARG A 1 332 ? 149.408 154.533 149.829 1.00 20.00  ? 403 ARG F C   1 
ATOM   2435 O O   . ARG A 1 332 ? 149.316 153.432 149.284 1.00 20.00  ? 403 ARG F O   1 
ATOM   2436 C CB  . ARG A 1 332 ? 149.752 155.512 147.536 1.00 20.00  ? 403 ARG F CB  1 
ATOM   2437 C CG  . ARG A 1 332 ? 149.302 156.588 146.553 1.00 20.00  ? 403 ARG F CG  1 
ATOM   2438 C CD  . ARG A 1 332 ? 150.263 157.766 146.510 1.00 20.00  ? 403 ARG F CD  1 
ATOM   2439 N NE  . ARG A 1 332 ? 149.912 158.715 145.460 1.00 20.00  ? 403 ARG F NE  1 
ATOM   2440 C CZ  . ARG A 1 332 ? 149.101 159.751 145.625 1.00 20.00  ? 403 ARG F CZ  1 
ATOM   2441 N NH1 . ARG A 1 332 ? 148.537 160.008 146.793 1.00 20.00  ? 403 ARG F NH1 1 
ATOM   2442 N NH2 . ARG A 1 332 ? 148.849 160.548 144.591 1.00 20.00  ? 403 ARG F NH2 1 
ATOM   2443 N N   . LYS A 1 333 ? 149.464 154.671 151.153 1.00 19.35  ? 404 LYS F N   1 
ATOM   2444 C CA  . LYS A 1 333 ? 149.413 153.525 152.052 1.00 19.35  ? 404 LYS F CA  1 
ATOM   2445 C C   . LYS A 1 333 ? 148.594 153.884 153.281 1.00 19.35  ? 404 LYS F C   1 
ATOM   2446 O O   . LYS A 1 333 ? 148.821 154.929 153.898 1.00 19.35  ? 404 LYS F O   1 
ATOM   2447 C CB  . LYS A 1 333 ? 150.822 153.084 152.465 1.00 19.35  ? 404 LYS F CB  1 
ATOM   2448 C CG  . LYS A 1 333 ? 150.850 151.893 153.409 1.00 19.35  ? 404 LYS F CG  1 
ATOM   2449 C CD  . LYS A 1 333 ? 152.276 151.510 153.770 1.00 19.35  ? 404 LYS F CD  1 
ATOM   2450 C CE  . LYS A 1 333 ? 152.998 152.654 154.463 1.00 19.35  ? 404 LYS F CE  1 
ATOM   2451 N NZ  . LYS A 1 333 ? 152.318 153.056 155.726 1.00 19.35  ? 404 LYS F NZ  1 
ATOM   2452 N N   . LEU A 1 334 ? 147.645 153.017 153.633 1.00 18.22  ? 405 LEU F N   1 
ATOM   2453 C CA  . LEU A 1 334 ? 146.829 153.188 154.828 1.00 18.22  ? 405 LEU F CA  1 
ATOM   2454 C C   . LEU A 1 334 ? 146.908 151.920 155.663 1.00 18.22  ? 405 LEU F C   1 
ATOM   2455 O O   . LEU A 1 334 ? 146.626 150.827 155.162 1.00 18.22  ? 405 LEU F O   1 
ATOM   2456 C CB  . LEU A 1 334 ? 145.372 153.501 154.470 1.00 18.22  ? 405 LEU F CB  1 
ATOM   2457 C CG  . LEU A 1 334 ? 144.419 153.730 155.644 1.00 18.22  ? 405 LEU F CG  1 
ATOM   2458 C CD1 . LEU A 1 334 ? 144.900 154.884 156.509 1.00 18.22  ? 405 LEU F CD1 1 
ATOM   2459 C CD2 . LEU A 1 334 ? 143.005 153.984 155.145 1.00 18.22  ? 405 LEU F CD2 1 
ATOM   2460 N N   . GLU A 1 335 ? 147.281 152.062 156.931 1.00 20.36  ? 406 GLU F N   1 
ATOM   2461 C CA  . GLU A 1 335 ? 147.494 150.927 157.818 1.00 20.36  ? 406 GLU F CA  1 
ATOM   2462 C C   . GLU A 1 335 ? 146.521 150.993 158.986 1.00 20.36  ? 406 GLU F C   1 
ATOM   2463 O O   . GLU A 1 335 ? 146.363 152.048 159.609 1.00 20.36  ? 406 GLU F O   1 
ATOM   2464 C CB  . GLU A 1 335 ? 148.935 150.896 158.333 1.00 20.36  ? 406 GLU F CB  1 
ATOM   2465 C CG  . GLU A 1 335 ? 149.982 150.739 157.243 1.00 20.36  ? 406 GLU F CG  1 
ATOM   2466 C CD  . GLU A 1 335 ? 151.393 150.689 157.793 1.00 20.36  ? 406 GLU F CD  1 
ATOM   2467 O OE1 . GLU A 1 335 ? 151.557 150.818 159.025 1.00 20.36  ? 406 GLU F OE1 1 
ATOM   2468 O OE2 . GLU A 1 335 ? 152.339 150.520 156.995 1.00 20.36  ? 406 GLU F OE2 1 
ATOM   2469 N N   . LYS A 1 336 ? 145.873 149.866 159.277 1.00 24.69  ? 407 LYS F N   1 
ATOM   2470 C CA  . LYS A 1 336 ? 144.997 149.732 160.436 1.00 24.69  ? 407 LYS F CA  1 
ATOM   2471 C C   . LYS A 1 336 ? 145.478 148.552 161.267 1.00 24.69  ? 407 LYS F C   1 
ATOM   2472 O O   . LYS A 1 336 ? 145.451 147.410 160.798 1.00 24.69  ? 407 LYS F O   1 
ATOM   2473 C CB  . LYS A 1 336 ? 143.540 149.539 160.011 1.00 24.69  ? 407 LYS F CB  1 
ATOM   2474 C CG  . LYS A 1 336 ? 142.922 150.752 159.336 1.00 24.69  ? 407 LYS F CG  1 
ATOM   2475 C CD  . LYS A 1 336 ? 142.906 151.952 160.269 1.00 24.69  ? 407 LYS F CD  1 
ATOM   2476 C CE  . LYS A 1 336 ? 142.230 153.149 159.621 1.00 24.69  ? 407 LYS F CE  1 
ATOM   2477 N NZ  . LYS A 1 336 ? 140.809 152.864 159.276 1.00 24.69  ? 407 LYS F NZ  1 
ATOM   2478 N N   . THR A 1 337 ? 145.909 148.824 162.496 1.00 32.85  ? 408 THR F N   1 
ATOM   2479 C CA  . THR A 1 337 ? 146.525 147.823 163.357 1.00 32.85  ? 408 THR F CA  1 
ATOM   2480 C C   . THR A 1 337 ? 145.561 147.427 164.466 1.00 32.85  ? 408 THR F C   1 
ATOM   2481 O O   . THR A 1 337 ? 144.956 148.292 165.108 1.00 32.85  ? 408 THR F O   1 
ATOM   2482 C CB  . THR A 1 337 ? 147.831 148.351 163.958 1.00 32.85  ? 408 THR F CB  1 
ATOM   2483 O OG1 . THR A 1 337 ? 148.716 148.754 162.905 1.00 32.85  ? 408 THR F OG1 1 
ATOM   2484 C CG2 . THR A 1 337 ? 148.508 147.277 164.797 1.00 32.85  ? 408 THR F CG2 1 
ATOM   2485 N N   . ILE A 1 338 ? 145.422 146.121 164.688 1.00 44.32  ? 409 ILE F N   1 
ATOM   2486 C CA  . ILE A 1 338 ? 144.586 145.575 165.750 1.00 44.32  ? 409 ILE F CA  1 
ATOM   2487 C C   . ILE A 1 338 ? 145.445 144.656 166.609 1.00 44.32  ? 409 ILE F C   1 
ATOM   2488 O O   . ILE A 1 338 ? 146.195 143.823 166.084 1.00 44.32  ? 409 ILE F O   1 
ATOM   2489 C CB  . ILE A 1 338 ? 143.361 144.828 165.187 1.00 44.32  ? 409 ILE F CB  1 
ATOM   2490 C CG1 . ILE A 1 338 ? 142.553 144.185 166.317 1.00 44.32  ? 409 ILE F CG1 1 
ATOM   2491 C CG2 . ILE A 1 338 ? 143.779 143.788 164.155 1.00 44.32  ? 409 ILE F CG2 1 
ATOM   2492 C CD1 . ILE A 1 338 ? 141.978 145.181 167.300 1.00 44.32  ? 409 ILE F CD1 1 
ATOM   2493 N N   . SER A 1 339 ? 145.344 144.818 167.924 1.00 60.14  ? 410 SER F N   1 
ATOM   2494 C CA  . SER A 1 339 ? 146.090 144.024 168.888 1.00 60.14  ? 410 SER F CA  1 
ATOM   2495 C C   . SER A 1 339 ? 145.158 143.021 169.563 1.00 60.14  ? 410 SER F C   1 
ATOM   2496 O O   . SER A 1 339 ? 143.954 142.973 169.298 1.00 60.14  ? 410 SER F O   1 
ATOM   2497 C CB  . SER A 1 339 ? 146.769 144.928 169.918 1.00 60.14  ? 410 SER F CB  1 
ATOM   2498 O OG  . SER A 1 339 ? 145.815 145.700 170.627 1.00 60.14  ? 410 SER F OG  1 
ATOM   2499 N N   . THR A 1 340 ? 145.735 142.210 170.450 1.00 64.20  ? 411 THR F N   1 
ATOM   2500 C CA  . THR A 1 340 ? 144.989 141.180 171.160 1.00 64.20  ? 411 THR F CA  1 
ATOM   2501 C C   . THR A 1 340 ? 144.667 141.556 172.601 1.00 64.20  ? 411 THR F C   1 
ATOM   2502 O O   . THR A 1 340 ? 143.872 140.859 173.241 1.00 64.20  ? 411 THR F O   1 
ATOM   2503 C CB  . THR A 1 340 ? 145.768 139.859 171.150 1.00 64.20  ? 411 THR F CB  1 
ATOM   2504 O OG1 . THR A 1 340 ? 146.932 139.982 171.975 1.00 64.20  ? 411 THR F OG1 1 
ATOM   2505 C CG2 . THR A 1 340 ? 146.199 139.508 169.736 1.00 64.20  ? 411 THR F CG2 1 
ATOM   2506 N N   . SER A 1 341 ? 145.255 142.629 173.123 1.00 75.92  ? 412 SER F N   1 
ATOM   2507 C CA  . SER A 1 341 ? 145.040 143.042 174.503 1.00 75.92  ? 412 SER F CA  1 
ATOM   2508 C C   . SER A 1 341 ? 143.826 143.945 174.674 1.00 75.92  ? 412 SER F C   1 
ATOM   2509 O O   . SER A 1 341 ? 143.501 144.311 175.808 1.00 75.92  ? 412 SER F O   1 
ATOM   2510 C CB  . SER A 1 341 ? 146.288 143.752 175.040 1.00 75.92  ? 412 SER F CB  1 
ATOM   2511 O OG  . SER A 1 341 ? 146.592 144.902 174.269 1.00 75.92  ? 412 SER F OG  1 
ATOM   2512 N N   . LEU A 1 342 ? 143.153 144.313 173.588 1.00 82.39  ? 413 LEU F N   1 
ATOM   2513 C CA  . LEU A 1 342 ? 141.980 145.175 173.673 1.00 82.39  ? 413 LEU F CA  1 
ATOM   2514 C C   . LEU A 1 342 ? 140.763 144.398 174.165 1.00 82.39  ? 413 LEU F C   1 
ATOM   2515 O O   . LEU A 1 342 ? 140.151 143.642 173.412 1.00 82.39  ? 413 LEU F O   1 
ATOM   2516 C CB  . LEU A 1 342 ? 141.683 145.812 172.314 1.00 82.39  ? 413 LEU F CB  1 
ATOM   2517 C CG  . LEU A 1 342 ? 142.775 146.715 171.736 1.00 82.39  ? 413 LEU F CG  1 
ATOM   2518 C CD1 . LEU A 1 342 ? 142.342 147.291 170.396 1.00 82.39  ? 413 LEU F CD1 1 
ATOM   2519 C CD2 . LEU A 1 342 ? 143.127 147.826 172.713 1.00 82.39  ? 413 LEU F CD2 1 
ATOM   2520 N N   . LYS B 2 29  ? 127.862 148.244 74.240  1.00 69.48  ? 29  LYS A N   1 
ATOM   2521 C CA  . LYS B 2 29  ? 129.122 148.048 74.947  1.00 69.48  ? 29  LYS A CA  1 
ATOM   2522 C C   . LYS B 2 29  ? 129.172 146.671 75.605  1.00 69.48  ? 29  LYS A C   1 
ATOM   2523 O O   . LYS B 2 29  ? 128.153 146.165 76.075  1.00 69.48  ? 29  LYS A O   1 
ATOM   2524 C CB  . LYS B 2 29  ? 129.325 149.146 75.995  1.00 69.48  ? 29  LYS A CB  1 
ATOM   2525 C CG  . LYS B 2 29  ? 128.197 149.262 77.009  1.00 69.48  ? 29  LYS A CG  1 
ATOM   2526 C CD  . LYS B 2 29  ? 128.471 150.368 78.016  1.00 69.48  ? 29  LYS A CD  1 
ATOM   2527 C CE  . LYS B 2 29  ? 128.610 151.718 77.330  1.00 69.48  ? 29  LYS A CE  1 
ATOM   2528 N NZ  . LYS B 2 29  ? 128.879 152.811 78.305  1.00 69.48  ? 29  LYS A NZ  1 
ATOM   2529 N N   . PRO B 2 30  ? 130.356 146.063 75.632  1.00 69.15  ? 30  PRO A N   1 
ATOM   2530 C CA  . PRO B 2 30  ? 130.499 144.747 76.264  1.00 69.15  ? 30  PRO A CA  1 
ATOM   2531 C C   . PRO B 2 30  ? 130.353 144.841 77.776  1.00 69.15  ? 30  PRO A C   1 
ATOM   2532 O O   . PRO B 2 30  ? 130.371 145.919 78.373  1.00 69.15  ? 30  PRO A O   1 
ATOM   2533 C CB  . PRO B 2 30  ? 131.910 144.311 75.861  1.00 69.15  ? 30  PRO A CB  1 
ATOM   2534 C CG  . PRO B 2 30  ? 132.639 145.591 75.627  1.00 69.15  ? 30  PRO A CG  1 
ATOM   2535 C CD  . PRO B 2 30  ? 131.624 146.540 75.054  1.00 69.15  ? 30  PRO A CD  1 
ATOM   2536 N N   . LYS B 2 31  ? 130.197 143.675 78.398  1.00 56.43  ? 31  LYS A N   1 
ATOM   2537 C CA  . LYS B 2 31  ? 130.006 143.572 79.838  1.00 56.43  ? 31  LYS A CA  1 
ATOM   2538 C C   . LYS B 2 31  ? 131.171 142.811 80.453  1.00 56.43  ? 31  LYS A C   1 
ATOM   2539 O O   . LYS B 2 31  ? 131.562 141.751 79.952  1.00 56.43  ? 31  LYS A O   1 
ATOM   2540 C CB  . LYS B 2 31  ? 128.683 142.876 80.170  1.00 56.43  ? 31  LYS A CB  1 
ATOM   2541 C CG  . LYS B 2 31  ? 128.349 142.855 81.653  1.00 56.43  ? 31  LYS A CG  1 
ATOM   2542 C CD  . LYS B 2 31  ? 127.009 142.184 81.909  1.00 56.43  ? 31  LYS A CD  1 
ATOM   2543 C CE  . LYS B 2 31  ? 126.638 142.235 83.382  1.00 56.43  ? 31  LYS A CE  1 
ATOM   2544 N NZ  . LYS B 2 31  ? 127.653 141.559 84.236  1.00 56.43  ? 31  LYS A NZ  1 
ATOM   2545 N N   . VAL B 2 32  ? 131.720 143.350 81.536  1.00 47.91  ? 32  VAL A N   1 
ATOM   2546 C CA  . VAL B 2 32  ? 132.804 142.703 82.265  1.00 47.91  ? 32  VAL A CA  1 
ATOM   2547 C C   . VAL B 2 32  ? 132.189 141.749 83.281  1.00 47.91  ? 32  VAL A C   1 
ATOM   2548 O O   . VAL B 2 32  ? 131.498 142.181 84.210  1.00 47.91  ? 32  VAL A O   1 
ATOM   2549 C CB  . VAL B 2 32  ? 133.708 143.734 82.955  1.00 47.91  ? 32  VAL A CB  1 
ATOM   2550 C CG1 . VAL B 2 32  ? 134.946 143.058 83.529  1.00 47.91  ? 32  VAL A CG1 1 
ATOM   2551 C CG2 . VAL B 2 32  ? 134.091 144.842 81.987  1.00 47.91  ? 32  VAL A CG2 1 
ATOM   2552 N N   . SER B 2 33  ? 132.439 140.455 83.107  1.00 46.96  ? 33  SER A N   1 
ATOM   2553 C CA  . SER B 2 33  ? 131.900 139.425 83.983  1.00 46.96  ? 33  SER A CA  1 
ATOM   2554 C C   . SER B 2 33  ? 133.031 138.798 84.785  1.00 46.96  ? 33  SER A C   1 
ATOM   2555 O O   . SER B 2 33  ? 134.088 138.475 84.231  1.00 46.96  ? 33  SER A O   1 
ATOM   2556 C CB  . SER B 2 33  ? 131.161 138.352 83.181  1.00 46.96  ? 33  SER A CB  1 
ATOM   2557 O OG  . SER B 2 33  ? 132.026 137.723 82.252  1.00 46.96  ? 33  SER A OG  1 
ATOM   2558 N N   . LEU B 2 34  ? 132.805 138.632 86.084  1.00 33.97  ? 34  LEU A N   1 
ATOM   2559 C CA  . LEU B 2 34  ? 133.774 138.027 86.985  1.00 33.97  ? 34  LEU A CA  1 
ATOM   2560 C C   . LEU B 2 34  ? 133.415 136.567 87.221  1.00 33.97  ? 34  LEU A C   1 
ATOM   2561 O O   . LEU B 2 34  ? 132.245 136.232 87.427  1.00 33.97  ? 34  LEU A O   1 
ATOM   2562 C CB  . LEU B 2 34  ? 133.819 138.773 88.321  1.00 33.97  ? 34  LEU A CB  1 
ATOM   2563 C CG  . LEU B 2 34  ? 133.963 140.295 88.266  1.00 33.97  ? 34  LEU A CG  1 
ATOM   2564 C CD1 . LEU B 2 34  ? 133.968 140.883 89.669  1.00 33.97  ? 34  LEU A CD1 1 
ATOM   2565 C CD2 . LEU B 2 34  ? 135.220 140.691 87.512  1.00 33.97  ? 34  LEU A CD2 1 
ATOM   2566 N N   . ASN B 2 35  ? 134.427 135.699 87.174  1.00 33.94  ? 35  ASN A N   1 
ATOM   2567 C CA  . ASN B 2 35  ? 134.195 134.287 87.470  1.00 33.94  ? 35  ASN A CA  1 
ATOM   2568 C C   . ASN B 2 35  ? 133.625 134.083 88.868  1.00 33.94  ? 35  ASN A C   1 
ATOM   2569 O O   . ASN B 2 35  ? 132.668 133.302 89.010  1.00 33.94  ? 35  ASN A O   1 
ATOM   2570 C CB  . ASN B 2 35  ? 135.486 133.490 87.251  1.00 33.94  ? 35  ASN A CB  1 
ATOM   2571 C CG  . ASN B 2 35  ? 135.294 131.999 87.453  1.00 33.94  ? 35  ASN A CG  1 
ATOM   2572 O OD1 . ASN B 2 35  ? 134.188 131.478 87.306  1.00 33.94  ? 35  ASN A OD1 1 
ATOM   2573 N ND2 . ASN B 2 35  ? 136.373 131.304 87.792  1.00 33.94  ? 35  ASN A ND2 1 
ATOM   2574 N N   . PRO B 2 36  ? 134.133 134.722 89.922  1.00 29.52  ? 36  PRO A N   1 
ATOM   2575 C CA  . PRO B 2 36  ? 133.395 134.739 91.187  1.00 29.52  ? 36  PRO A CA  1 
ATOM   2576 C C   . PRO B 2 36  ? 132.255 135.737 91.118  1.00 29.52  ? 36  PRO A C   1 
ATOM   2577 O O   . PRO B 2 36  ? 132.452 136.889 90.701  1.00 29.52  ? 36  PRO A O   1 
ATOM   2578 C CB  . PRO B 2 36  ? 134.454 135.171 92.216  1.00 29.52  ? 36  PRO A CB  1 
ATOM   2579 C CG  . PRO B 2 36  ? 135.771 135.034 91.520  1.00 29.52  ? 36  PRO A CG  1 
ATOM   2580 C CD  . PRO B 2 36  ? 135.474 135.308 90.086  1.00 29.52  ? 36  PRO A CD  1 
ATOM   2581 N N   . PRO B 2 37  ? 131.043 135.338 91.514  1.00 21.44  ? 37  PRO A N   1 
ATOM   2582 C CA  . PRO B 2 37  ? 129.898 136.260 91.449  1.00 21.44  ? 37  PRO A CA  1 
ATOM   2583 C C   . PRO B 2 37  ? 129.996 137.452 92.389  1.00 21.44  ? 37  PRO A C   1 
ATOM   2584 O O   . PRO B 2 37  ? 129.061 138.260 92.430  1.00 21.44  ? 37  PRO A O   1 
ATOM   2585 C CB  . PRO B 2 37  ? 128.707 135.364 91.828  1.00 21.44  ? 37  PRO A CB  1 
ATOM   2586 C CG  . PRO B 2 37  ? 129.171 133.969 91.555  1.00 21.44  ? 37  PRO A CG  1 
ATOM   2587 C CD  . PRO B 2 37  ? 130.633 133.971 91.873  1.00 21.44  ? 37  PRO A CD  1 
ATOM   2588 N N   . TRP B 2 38  ? 131.084 137.595 93.142  1.00 18.97  ? 38  TRP A N   1 
ATOM   2589 C CA  . TRP B 2 38  ? 131.246 138.677 94.104  1.00 18.97  ? 38  TRP A CA  1 
ATOM   2590 C C   . TRP B 2 38  ? 132.468 139.504 93.733  1.00 18.97  ? 38  TRP A C   1 
ATOM   2591 O O   . TRP B 2 38  ? 133.521 138.950 93.402  1.00 18.97  ? 38  TRP A O   1 
ATOM   2592 C CB  . TRP B 2 38  ? 131.384 138.124 95.524  1.00 18.97  ? 38  TRP A CB  1 
ATOM   2593 C CG  . TRP B 2 38  ? 130.459 136.979 95.793  1.00 18.97  ? 38  TRP A CG  1 
ATOM   2594 C CD1 . TRP B 2 38  ? 129.172 137.051 96.238  1.00 18.97  ? 38  TRP A CD1 1 
ATOM   2595 C CD2 . TRP B 2 38  ? 130.748 135.587 95.622  1.00 18.97  ? 38  TRP A CD2 1 
ATOM   2596 N NE1 . TRP B 2 38  ? 128.642 135.790 96.359  1.00 18.97  ? 38  TRP A NE1 1 
ATOM   2597 C CE2 . TRP B 2 38  ? 129.589 134.873 95.987  1.00 18.97  ? 38  TRP A CE2 1 
ATOM   2598 C CE3 . TRP B 2 38  ? 131.874 134.874 95.199  1.00 18.97  ? 38  TRP A CE3 1 
ATOM   2599 C CZ2 . TRP B 2 38  ? 129.524 133.483 95.939  1.00 18.97  ? 38  TRP A CZ2 1 
ATOM   2600 C CZ3 . TRP B 2 38  ? 131.807 133.493 95.155  1.00 18.97  ? 38  TRP A CZ3 1 
ATOM   2601 C CH2 . TRP B 2 38  ? 130.641 132.812 95.523  1.00 18.97  ? 38  TRP A CH2 1 
ATOM   2602 N N   . ASN B 2 39  ? 132.323 140.830 93.790  1.00 18.96  ? 39  ASN A N   1 
ATOM   2603 C CA  . ASN B 2 39  ? 133.401 141.759 93.470  1.00 18.96  ? 39  ASN A CA  1 
ATOM   2604 C C   . ASN B 2 39  ? 134.185 142.195 94.703  1.00 18.96  ? 39  ASN A C   1 
ATOM   2605 O O   . ASN B 2 39  ? 134.720 143.312 94.732  1.00 18.96  ? 39  ASN A O   1 
ATOM   2606 C CB  . ASN B 2 39  ? 132.841 142.976 92.733  1.00 18.96  ? 39  ASN A CB  1 
ATOM   2607 C CG  . ASN B 2 39  ? 131.617 143.558 93.413  1.00 18.96  ? 39  ASN A CG  1 
ATOM   2608 O OD1 . ASN B 2 39  ? 131.314 143.231 94.560  1.00 18.96  ? 39  ASN A OD1 1 
ATOM   2609 N ND2 . ASN B 2 39  ? 130.905 144.428 92.706  1.00 18.96  ? 39  ASN A ND2 1 
ATOM   2610 N N   . ARG B 2 40  ? 134.265 141.345 95.722  1.00 15.50  ? 40  ARG A N   1 
ATOM   2611 C CA  . ARG B 2 40  ? 134.969 141.633 96.969  1.00 15.50  ? 40  ARG A CA  1 
ATOM   2612 C C   . ARG B 2 40  ? 135.973 140.529 97.271  1.00 15.50  ? 40  ARG A C   1 
ATOM   2613 O O   . ARG B 2 40  ? 136.019 139.976 98.372  1.00 15.50  ? 40  ARG A O   1 
ATOM   2614 C CB  . ARG B 2 40  ? 133.988 141.804 98.125  1.00 15.50  ? 40  ARG A CB  1 
ATOM   2615 C CG  . ARG B 2 40  ? 132.999 142.942 97.941  1.00 15.50  ? 40  ARG A CG  1 
ATOM   2616 C CD  . ARG B 2 40  ? 132.097 143.083 99.156  1.00 15.50  ? 40  ARG A CD  1 
ATOM   2617 N NE  . ARG B 2 40  ? 132.851 143.419 100.358 1.00 15.50  ? 40  ARG A NE  1 
ATOM   2618 C CZ  . ARG B 2 40  ? 132.330 143.481 101.576 1.00 15.50  ? 40  ARG A CZ  1 
ATOM   2619 N NH1 . ARG B 2 40  ? 131.051 143.224 101.794 1.00 15.50  ? 40  ARG A NH1 1 
ATOM   2620 N NH2 . ARG B 2 40  ? 133.112 143.805 102.601 1.00 15.50  ? 40  ARG A NH2 1 
ATOM   2621 N N   . ILE B 2 41  ? 136.793 140.187 96.272  1.00 19.20  ? 41  ILE A N   1 
ATOM   2622 C CA  . ILE B 2 41  ? 137.733 139.082 96.425  1.00 19.20  ? 41  ILE A CA  1 
ATOM   2623 C C   . ILE B 2 41  ? 138.746 139.385 97.530  1.00 19.20  ? 41  ILE A C   1 
ATOM   2624 O O   . ILE B 2 41  ? 138.938 140.534 97.949  1.00 19.20  ? 41  ILE A O   1 
ATOM   2625 C CB  . ILE B 2 41  ? 138.449 138.780 95.099  1.00 19.20  ? 41  ILE A CB  1 
ATOM   2626 C CG1 . ILE B 2 41  ? 139.338 139.956 94.691  1.00 19.20  ? 41  ILE A CG1 1 
ATOM   2627 C CG2 . ILE B 2 41  ? 137.437 138.471 94.007  1.00 19.20  ? 41  ILE A CG2 1 
ATOM   2628 C CD1 . ILE B 2 41  ? 140.181 139.686 93.464  1.00 19.20  ? 41  ILE A CD1 1 
ATOM   2629 N N   . PHE B 2 42  ? 139.400 138.328 98.003  1.00 21.00  ? 42  PHE A N   1 
ATOM   2630 C CA  . PHE B 2 42  ? 140.358 138.423 99.096  1.00 21.00  ? 42  PHE A CA  1 
ATOM   2631 C C   . PHE B 2 42  ? 141.696 138.943 98.573  1.00 21.00  ? 42  PHE A C   1 
ATOM   2632 O O   . PHE B 2 42  ? 141.830 139.348 97.415  1.00 21.00  ? 42  PHE A O   1 
ATOM   2633 C CB  . PHE B 2 42  ? 140.522 137.066 99.775  1.00 21.00  ? 42  PHE A CB  1 
ATOM   2634 C CG  . PHE B 2 42  ? 139.371 136.679 100.658 1.00 21.00  ? 42  PHE A CG  1 
ATOM   2635 C CD1 . PHE B 2 42  ? 138.117 136.437 100.124 1.00 21.00  ? 42  PHE A CD1 1 
ATOM   2636 C CD2 . PHE B 2 42  ? 139.551 136.536 102.023 1.00 21.00  ? 42  PHE A CD2 1 
ATOM   2637 C CE1 . PHE B 2 42  ? 137.063 136.073 100.935 1.00 21.00  ? 42  PHE A CE1 1 
ATOM   2638 C CE2 . PHE B 2 42  ? 138.501 136.170 102.838 1.00 21.00  ? 42  PHE A CE2 1 
ATOM   2639 C CZ  . PHE B 2 42  ? 137.254 135.942 102.294 1.00 21.00  ? 42  PHE A CZ  1 
ATOM   2640 N N   . LYS B 2 43  ? 142.708 138.932 99.436  1.00 22.74  ? 43  LYS A N   1 
ATOM   2641 C CA  . LYS B 2 43  ? 144.073 139.283 99.064  1.00 22.74  ? 43  LYS A CA  1 
ATOM   2642 C C   . LYS B 2 43  ? 144.830 137.992 98.775  1.00 22.74  ? 43  LYS A C   1 
ATOM   2643 O O   . LYS B 2 43  ? 145.208 137.266 99.700  1.00 22.74  ? 43  LYS A O   1 
ATOM   2644 C CB  . LYS B 2 43  ? 144.753 140.086 100.171 1.00 22.74  ? 43  LYS A CB  1 
ATOM   2645 C CG  . LYS B 2 43  ? 146.204 140.434 99.883  1.00 22.74  ? 43  LYS A CG  1 
ATOM   2646 C CD  . LYS B 2 43  ? 146.846 141.149 101.060 1.00 22.74  ? 43  LYS A CD  1 
ATOM   2647 C CE  . LYS B 2 43  ? 148.300 141.487 100.774 1.00 22.74  ? 43  LYS A CE  1 
ATOM   2648 N NZ  . LYS B 2 43  ? 148.441 142.368 99.582  1.00 22.74  ? 43  LYS A NZ  1 
ATOM   2649 N N   . GLY B 2 44  ? 145.049 137.709 97.495  1.00 29.16  ? 44  GLY A N   1 
ATOM   2650 C CA  . GLY B 2 44  ? 145.724 136.499 97.079  1.00 29.16  ? 44  GLY A CA  1 
ATOM   2651 C C   . GLY B 2 44  ? 144.878 135.502 96.316  1.00 29.16  ? 44  GLY A C   1 
ATOM   2652 O O   . GLY B 2 44  ? 145.370 134.409 96.012  1.00 29.16  ? 44  GLY A O   1 
ATOM   2653 N N   . GLU B 2 45  ? 143.631 135.834 95.997  1.00 28.14  ? 45  GLU A N   1 
ATOM   2654 C CA  . GLU B 2 45  ? 142.762 134.933 95.258  1.00 28.14  ? 45  GLU A CA  1 
ATOM   2655 C C   . GLU B 2 45  ? 142.908 135.150 93.753  1.00 28.14  ? 45  GLU A C   1 
ATOM   2656 O O   . GLU B 2 45  ? 143.489 136.133 93.288  1.00 28.14  ? 45  GLU A O   1 
ATOM   2657 C CB  . GLU B 2 45  ? 141.305 135.121 95.683  1.00 28.14  ? 45  GLU A CB  1 
ATOM   2658 C CG  . GLU B 2 45  ? 140.988 134.590 97.070  1.00 28.14  ? 45  GLU A CG  1 
ATOM   2659 C CD  . GLU B 2 45  ? 139.513 134.689 97.407  1.00 28.14  ? 45  GLU A CD  1 
ATOM   2660 O OE1 . GLU B 2 45  ? 138.791 135.432 96.709  1.00 28.14  ? 45  GLU A OE1 1 
ATOM   2661 O OE2 . GLU B 2 45  ? 139.075 134.022 98.368  1.00 28.14  ? 45  GLU A OE2 1 
ATOM   2662 N N   . ASN B 2 46  ? 142.365 134.207 92.989  1.00 34.31  ? 46  ASN A N   1 
ATOM   2663 C CA  . ASN B 2 46  ? 142.377 134.260 91.534  1.00 34.31  ? 46  ASN A CA  1 
ATOM   2664 C C   . ASN B 2 46  ? 141.020 134.738 91.037  1.00 34.31  ? 46  ASN A C   1 
ATOM   2665 O O   . ASN B 2 46  ? 139.981 134.244 91.488  1.00 34.31  ? 46  ASN A O   1 
ATOM   2666 C CB  . ASN B 2 46  ? 142.696 132.886 90.940  1.00 34.31  ? 46  ASN A CB  1 
ATOM   2667 C CG  . ASN B 2 46  ? 144.008 132.321 91.443  1.00 34.31  ? 46  ASN A CG  1 
ATOM   2668 O OD1 . ASN B 2 46  ? 144.673 132.918 92.290  1.00 34.31  ? 46  ASN A OD1 1 
ATOM   2669 N ND2 . ASN B 2 46  ? 144.384 131.158 90.925  1.00 34.31  ? 46  ASN A ND2 1 
ATOM   2670 N N   . VAL B 2 47  ? 141.029 135.695 90.112  1.00 37.76  ? 47  VAL A N   1 
ATOM   2671 C CA  . VAL B 2 47  ? 139.802 136.227 89.532  1.00 37.76  ? 47  VAL A CA  1 
ATOM   2672 C C   . VAL B 2 47  ? 139.948 136.270 88.017  1.00 37.76  ? 47  VAL A C   1 
ATOM   2673 O O   . VAL B 2 47  ? 140.996 136.662 87.492  1.00 37.76  ? 47  VAL A O   1 
ATOM   2674 C CB  . VAL B 2 47  ? 139.454 137.622 90.102  1.00 37.76  ? 47  VAL A CB  1 
ATOM   2675 C CG1 . VAL B 2 47  ? 140.608 138.592 89.918  1.00 37.76  ? 47  VAL A CG1 1 
ATOM   2676 C CG2 . VAL B 2 47  ? 138.181 138.164 89.464  1.00 37.76  ? 47  VAL A CG2 1 
ATOM   2677 N N   . THR B 2 48  ? 138.900 135.847 87.315  1.00 39.51  ? 48  THR A N   1 
ATOM   2678 C CA  . THR B 2 48  ? 138.878 135.820 85.858  1.00 39.51  ? 48  THR A CA  1 
ATOM   2679 C C   . THR B 2 48  ? 137.863 136.839 85.359  1.00 39.51  ? 48  THR A C   1 
ATOM   2680 O O   . THR B 2 48  ? 136.691 136.796 85.748  1.00 39.51  ? 48  THR A O   1 
ATOM   2681 C CB  . THR B 2 48  ? 138.537 134.423 85.338  1.00 39.51  ? 48  THR A CB  1 
ATOM   2682 O OG1 . THR B 2 48  ? 139.509 133.484 85.813  1.00 39.51  ? 48  THR A OG1 1 
ATOM   2683 C CG2 . THR B 2 48  ? 138.527 134.409 83.817  1.00 39.51  ? 48  THR A CG2 1 
ATOM   2684 N N   . LEU B 2 49  ? 138.315 137.747 84.501  1.00 47.37  ? 49  LEU A N   1 
ATOM   2685 C CA  . LEU B 2 49  ? 137.473 138.772 83.901  1.00 47.37  ? 49  LEU A CA  1 
ATOM   2686 C C   . LEU B 2 49  ? 137.246 138.435 82.435  1.00 47.37  ? 49  LEU A C   1 
ATOM   2687 O O   . LEU B 2 49  ? 138.207 138.200 81.693  1.00 47.37  ? 49  LEU A O   1 
ATOM   2688 C CB  . LEU B 2 49  ? 138.109 140.160 84.027  1.00 47.37  ? 49  LEU A CB  1 
ATOM   2689 C CG  . LEU B 2 49  ? 138.191 140.817 85.407  1.00 47.37  ? 49  LEU A CG  1 
ATOM   2690 C CD1 . LEU B 2 49  ? 139.333 140.251 86.242  1.00 47.37  ? 49  LEU A CD1 1 
ATOM   2691 C CD2 . LEU B 2 49  ? 138.325 142.324 85.262  1.00 47.37  ? 49  LEU A CD2 1 
ATOM   2692 N N   . THR B 2 50  ? 135.981 138.411 82.024  1.00 54.99  ? 50  THR A N   1 
ATOM   2693 C CA  . THR B 2 50  ? 135.600 138.115 80.650  1.00 54.99  ? 50  THR A CA  1 
ATOM   2694 C C   . THR B 2 50  ? 134.852 139.306 80.068  1.00 54.99  ? 50  THR A C   1 
ATOM   2695 O O   . THR B 2 50  ? 133.925 139.829 80.695  1.00 54.99  ? 50  THR A O   1 
ATOM   2696 C CB  . THR B 2 50  ? 134.732 136.855 80.575  1.00 54.99  ? 50  THR A CB  1 
ATOM   2697 O OG1 . THR B 2 50  ? 135.421 135.760 81.192  1.00 54.99  ? 50  THR A OG1 1 
ATOM   2698 C CG2 . THR B 2 50  ? 134.429 136.502 79.127  1.00 54.99  ? 50  THR A CG2 1 
ATOM   2699 N N   . CYS B 2 51  ? 135.262 139.732 78.874  1.00 63.99  ? 51  CYS A N   1 
ATOM   2700 C CA  . CYS B 2 51  ? 134.621 140.850 78.179  1.00 63.99  ? 51  CYS A CA  1 
ATOM   2701 C C   . CYS B 2 51  ? 133.520 140.307 77.267  1.00 63.99  ? 51  CYS A C   1 
ATOM   2702 O O   . CYS B 2 51  ? 133.640 140.254 76.041  1.00 63.99  ? 51  CYS A O   1 
ATOM   2703 C CB  . CYS B 2 51  ? 135.657 141.652 77.402  1.00 63.99  ? 51  CYS A CB  1 
ATOM   2704 S SG  . CYS B 2 51  ? 135.189 143.356 77.013  1.00 63.99  ? 51  CYS A SG  1 
ATOM   2705 N N   . ASN B 2 52  ? 132.426 139.891 77.902  1.00 69.60  ? 52  ASN A N   1 
ATOM   2706 C CA  . ASN B 2 52  ? 131.344 139.241 77.177  1.00 69.60  ? 52  ASN A CA  1 
ATOM   2707 C C   . ASN B 2 52  ? 130.630 140.227 76.260  1.00 69.60  ? 52  ASN A C   1 
ATOM   2708 O O   . ASN B 2 52  ? 130.414 141.390 76.613  1.00 69.60  ? 52  ASN A O   1 
ATOM   2709 C CB  . ASN B 2 52  ? 130.347 138.620 78.154  1.00 69.60  ? 52  ASN A CB  1 
ATOM   2710 C CG  . ASN B 2 52  ? 130.910 137.407 78.867  1.00 69.60  ? 52  ASN A CG  1 
ATOM   2711 O OD1 . ASN B 2 52  ? 131.073 137.409 80.087  1.00 69.60  ? 52  ASN A OD1 1 
ATOM   2712 N ND2 . ASN B 2 52  ? 131.207 136.359 78.107  1.00 69.60  ? 52  ASN A ND2 1 
ATOM   2713 N N   . GLY B 2 53  ? 130.265 139.749 75.073  1.00 105.70 ? 53  GLY A N   1 
ATOM   2714 C CA  . GLY B 2 53  ? 129.554 140.554 74.102  1.00 105.70 ? 53  GLY A CA  1 
ATOM   2715 C C   . GLY B 2 53  ? 129.150 139.754 72.881  1.00 105.70 ? 53  GLY A C   1 
ATOM   2716 O O   . GLY B 2 53  ? 129.929 138.937 72.382  1.00 105.70 ? 53  GLY A O   1 
ATOM   2717 N N   . ASN B 2 54  ? 127.935 139.978 72.392  1.00 124.85 ? 54  ASN A N   1 
ATOM   2718 C CA  . ASN B 2 54  ? 127.414 139.233 71.256  1.00 124.85 ? 54  ASN A CA  1 
ATOM   2719 C C   . ASN B 2 54  ? 127.820 139.892 69.943  1.00 124.85 ? 54  ASN A C   1 
ATOM   2720 O O   . ASN B 2 54  ? 128.001 141.111 69.866  1.00 124.85 ? 54  ASN A O   1 
ATOM   2721 C CB  . ASN B 2 54  ? 125.890 139.127 71.334  1.00 124.85 ? 54  ASN A CB  1 
ATOM   2722 C CG  . ASN B 2 54  ? 125.420 138.408 72.583  1.00 124.85 ? 54  ASN A CG  1 
ATOM   2723 O OD1 . ASN B 2 54  ? 126.154 138.300 73.565  1.00 124.85 ? 54  ASN A OD1 1 
ATOM   2724 N ND2 . ASN B 2 54  ? 124.189 137.910 72.552  1.00 124.85 ? 54  ASN A ND2 1 
ATOM   2725 N N   . ASN B 2 55  ? 127.960 139.062 68.906  1.00 133.57 ? 55  ASN A N   1 
ATOM   2726 C CA  . ASN B 2 55  ? 128.304 139.519 67.558  1.00 133.57 ? 55  ASN A CA  1 
ATOM   2727 C C   . ASN B 2 55  ? 129.608 140.315 67.549  1.00 133.57 ? 55  ASN A C   1 
ATOM   2728 O O   . ASN B 2 55  ? 129.727 141.340 66.876  1.00 133.57 ? 55  ASN A O   1 
ATOM   2729 C CB  . ASN B 2 55  ? 127.165 140.337 66.945  1.00 133.57 ? 55  ASN A CB  1 
ATOM   2730 C CG  . ASN B 2 55  ? 125.857 139.572 66.898  1.00 133.57 ? 55  ASN A CG  1 
ATOM   2731 O OD1 . ASN B 2 55  ? 124.857 139.991 67.481  1.00 133.57 ? 55  ASN A OD1 1 
ATOM   2732 N ND2 . ASN B 2 55  ? 125.858 138.441 66.201  1.00 133.57 ? 55  ASN A ND2 1 
ATOM   2733 N N   . PHE B 2 56  ? 130.597 139.839 68.305  1.00 122.97 ? 56  PHE A N   1 
ATOM   2734 C CA  . PHE B 2 56  ? 131.893 140.500 68.398  1.00 122.97 ? 56  PHE A CA  1 
ATOM   2735 C C   . PHE B 2 56  ? 133.004 139.689 67.743  1.00 122.97 ? 56  PHE A C   1 
ATOM   2736 O O   . PHE B 2 56  ? 133.706 140.206 66.868  1.00 122.97 ? 56  PHE A O   1 
ATOM   2737 C CB  . PHE B 2 56  ? 132.236 140.783 69.867  1.00 122.97 ? 56  PHE A CB  1 
ATOM   2738 C CG  . PHE B 2 56  ? 131.532 141.982 70.435  1.00 122.97 ? 56  PHE A CG  1 
ATOM   2739 C CD1 . PHE B 2 56  ? 130.821 142.840 69.613  1.00 122.97 ? 56  PHE A CD1 1 
ATOM   2740 C CD2 . PHE B 2 56  ? 131.592 142.258 71.791  1.00 122.97 ? 56  PHE A CD2 1 
ATOM   2741 C CE1 . PHE B 2 56  ? 130.175 143.946 70.134  1.00 122.97 ? 56  PHE A CE1 1 
ATOM   2742 C CE2 . PHE B 2 56  ? 130.949 143.362 72.318  1.00 122.97 ? 56  PHE A CE2 1 
ATOM   2743 C CZ  . PHE B 2 56  ? 130.239 144.207 71.488  1.00 122.97 ? 56  PHE A CZ  1 
ATOM   2744 N N   . PHE B 2 57  ? 133.181 138.429 68.149  1.00 124.16 ? 57  PHE A N   1 
ATOM   2745 C CA  . PHE B 2 57  ? 134.257 137.574 67.655  1.00 124.16 ? 57  PHE A CA  1 
ATOM   2746 C C   . PHE B 2 57  ? 135.616 138.230 67.876  1.00 124.16 ? 57  PHE A C   1 
ATOM   2747 O O   . PHE B 2 57  ? 135.746 139.124 68.719  1.00 124.16 ? 57  PHE A O   1 
ATOM   2748 C CB  . PHE B 2 57  ? 134.056 137.248 66.171  1.00 124.16 ? 57  PHE A CB  1 
ATOM   2749 C CG  . PHE B 2 57  ? 132.759 136.551 65.871  1.00 124.16 ? 57  PHE A CG  1 
ATOM   2750 C CD1 . PHE B 2 57  ? 132.172 135.713 66.805  1.00 124.16 ? 57  PHE A CD1 1 
ATOM   2751 C CD2 . PHE B 2 57  ? 132.125 136.737 64.654  1.00 124.16 ? 57  PHE A CD2 1 
ATOM   2752 C CE1 . PHE B 2 57  ? 130.979 135.072 66.530  1.00 124.16 ? 57  PHE A CE1 1 
ATOM   2753 C CE2 . PHE B 2 57  ? 130.931 136.100 64.372  1.00 124.16 ? 57  PHE A CE2 1 
ATOM   2754 C CZ  . PHE B 2 57  ? 130.357 135.266 65.312  1.00 124.16 ? 57  PHE A CZ  1 
ATOM   2755 N N   . GLU B 2 58  ? 136.628 137.788 67.131  1.00 117.46 ? 58  GLU A N   1 
ATOM   2756 C CA  . GLU B 2 58  ? 137.968 138.374 67.164  1.00 117.46 ? 58  GLU A CA  1 
ATOM   2757 C C   . GLU B 2 58  ? 138.518 138.424 68.591  1.00 117.46 ? 58  GLU A C   1 
ATOM   2758 O O   . GLU B 2 58  ? 138.743 139.489 69.169  1.00 117.46 ? 58  GLU A O   1 
ATOM   2759 C CB  . GLU B 2 58  ? 137.969 139.764 66.522  1.00 117.46 ? 58  GLU A CB  1 
ATOM   2760 C CG  . GLU B 2 58  ? 137.583 139.765 65.051  1.00 117.46 ? 58  GLU A CG  1 
ATOM   2761 C CD  . GLU B 2 58  ? 137.635 141.150 64.436  1.00 117.46 ? 58  GLU A CD  1 
ATOM   2762 O OE1 . GLU B 2 58  ? 137.942 142.116 65.166  1.00 117.46 ? 58  GLU A OE1 1 
ATOM   2763 O OE2 . GLU B 2 58  ? 137.369 141.272 63.222  1.00 117.46 ? 58  GLU A OE2 1 
ATOM   2764 N N   . VAL B 2 59  ? 138.724 137.232 69.158  1.00 111.53 ? 59  VAL A N   1 
ATOM   2765 C CA  . VAL B 2 59  ? 139.218 137.126 70.529  1.00 111.53 ? 59  VAL A CA  1 
ATOM   2766 C C   . VAL B 2 59  ? 140.601 137.750 70.663  1.00 111.53 ? 59  VAL A C   1 
ATOM   2767 O O   . VAL B 2 59  ? 140.962 138.258 71.732  1.00 111.53 ? 59  VAL A O   1 
ATOM   2768 C CB  . VAL B 2 59  ? 139.218 135.650 70.975  1.00 111.53 ? 59  VAL A CB  1 
ATOM   2769 C CG1 . VAL B 2 59  ? 139.542 135.534 72.457  1.00 111.53 ? 59  VAL A CG1 1 
ATOM   2770 C CG2 . VAL B 2 59  ? 137.877 135.002 70.663  1.00 111.53 ? 59  VAL A CG2 1 
ATOM   2771 N N   . SER B 2 60  ? 141.391 137.738 69.587  1.00 110.99 ? 60  SER A N   1 
ATOM   2772 C CA  . SER B 2 60  ? 142.749 138.267 69.632  1.00 110.99 ? 60  SER A CA  1 
ATOM   2773 C C   . SER B 2 60  ? 142.800 139.783 69.786  1.00 110.99 ? 60  SER A C   1 
ATOM   2774 O O   . SER B 2 60  ? 143.881 140.322 70.044  1.00 110.99 ? 60  SER A O   1 
ATOM   2775 C CB  . SER B 2 60  ? 143.512 137.855 68.371  1.00 110.99 ? 60  SER A CB  1 
ATOM   2776 O OG  . SER B 2 60  ? 142.881 138.358 67.206  1.00 110.99 ? 60  SER A OG  1 
ATOM   2777 N N   . SER B 2 61  ? 141.676 140.479 69.634  1.00 104.01 ? 61  SER A N   1 
ATOM   2778 C CA  . SER B 2 61  ? 141.622 141.937 69.728  1.00 104.01 ? 61  SER A CA  1 
ATOM   2779 C C   . SER B 2 61  ? 140.750 142.312 70.924  1.00 104.01 ? 61  SER A C   1 
ATOM   2780 O O   . SER B 2 61  ? 139.526 142.413 70.808  1.00 104.01 ? 61  SER A O   1 
ATOM   2781 C CB  . SER B 2 61  ? 141.091 142.549 68.432  1.00 104.01 ? 61  SER A CB  1 
ATOM   2782 O OG  . SER B 2 61  ? 139.784 142.083 68.146  1.00 104.01 ? 61  SER A OG  1 
ATOM   2783 N N   . THR B 2 62  ? 141.387 142.518 72.076  1.00 84.29  ? 62  THR A N   1 
ATOM   2784 C CA  . THR B 2 62  ? 140.679 142.918 73.291  1.00 84.29  ? 62  THR A CA  1 
ATOM   2785 C C   . THR B 2 62  ? 141.654 143.677 74.179  1.00 84.29  ? 62  THR A C   1 
ATOM   2786 O O   . THR B 2 62  ? 142.577 143.078 74.741  1.00 84.29  ? 62  THR A O   1 
ATOM   2787 C CB  . THR B 2 62  ? 140.103 141.707 74.023  1.00 84.29  ? 62  THR A CB  1 
ATOM   2788 O OG1 . THR B 2 62  ? 139.151 141.044 73.182  1.00 84.29  ? 62  THR A OG1 1 
ATOM   2789 C CG2 . THR B 2 62  ? 139.418 142.141 75.310  1.00 84.29  ? 62  THR A CG2 1 
ATOM   2790 N N   . LYS B 2 63  ? 141.451 144.986 74.306  1.00 67.44  ? 63  LYS A N   1 
ATOM   2791 C CA  . LYS B 2 63  ? 142.307 145.825 75.132  1.00 67.44  ? 63  LYS A CA  1 
ATOM   2792 C C   . LYS B 2 63  ? 141.747 145.920 76.545  1.00 67.44  ? 63  LYS A C   1 
ATOM   2793 O O   . LYS B 2 63  ? 140.529 145.974 76.742  1.00 67.44  ? 63  LYS A O   1 
ATOM   2794 C CB  . LYS B 2 63  ? 142.435 147.223 74.525  1.00 67.44  ? 63  LYS A CB  1 
ATOM   2795 C CG  . LYS B 2 63  ? 143.005 147.237 73.116  1.00 67.44  ? 63  LYS A CG  1 
ATOM   2796 C CD  . LYS B 2 63  ? 143.038 148.645 72.546  1.00 67.44  ? 63  LYS A CD  1 
ATOM   2797 C CE  . LYS B 2 63  ? 141.640 149.237 72.457  1.00 67.44  ? 63  LYS A CE  1 
ATOM   2798 N NZ  . LYS B 2 63  ? 140.751 148.432 71.575  1.00 67.44  ? 63  LYS A NZ  1 
ATOM   2799 N N   . TRP B 2 64  ? 142.644 145.938 77.527  1.00 58.48  ? 64  TRP A N   1 
ATOM   2800 C CA  . TRP B 2 64  ? 142.274 146.033 78.932  1.00 58.48  ? 64  TRP A CA  1 
ATOM   2801 C C   . TRP B 2 64  ? 142.901 147.275 79.548  1.00 58.48  ? 64  TRP A C   1 
ATOM   2802 O O   . TRP B 2 64  ? 144.086 147.556 79.337  1.00 58.48  ? 64  TRP A O   1 
ATOM   2803 C CB  . TRP B 2 64  ? 142.711 144.785 79.706  1.00 58.48  ? 64  TRP A CB  1 
ATOM   2804 C CG  . TRP B 2 64  ? 141.947 143.554 79.334  1.00 58.48  ? 64  TRP A CG  1 
ATOM   2805 C CD1 . TRP B 2 64  ? 142.241 142.678 78.331  1.00 58.48  ? 64  TRP A CD1 1 
ATOM   2806 C CD2 . TRP B 2 64  ? 140.758 143.060 79.963  1.00 58.48  ? 64  TRP A CD2 1 
ATOM   2807 N NE1 . TRP B 2 64  ? 141.309 141.668 78.296  1.00 58.48  ? 64  TRP A NE1 1 
ATOM   2808 C CE2 . TRP B 2 64  ? 140.388 141.880 79.288  1.00 58.48  ? 64  TRP A CE2 1 
ATOM   2809 C CE3 . TRP B 2 64  ? 139.971 143.501 81.032  1.00 58.48  ? 64  TRP A CE3 1 
ATOM   2810 C CZ2 . TRP B 2 64  ? 139.266 141.136 79.646  1.00 58.48  ? 64  TRP A CZ2 1 
ATOM   2811 C CZ3 . TRP B 2 64  ? 138.858 142.760 81.385  1.00 58.48  ? 64  TRP A CZ3 1 
ATOM   2812 C CH2 . TRP B 2 64  ? 138.516 141.592 80.694  1.00 58.48  ? 64  TRP A CH2 1 
ATOM   2813 N N   . PHE B 2 65  ? 142.100 148.015 80.310  1.00 49.76  ? 65  PHE A N   1 
ATOM   2814 C CA  . PHE B 2 65  ? 142.521 149.254 80.945  1.00 49.76  ? 65  PHE A CA  1 
ATOM   2815 C C   . PHE B 2 65  ? 142.383 149.126 82.455  1.00 49.76  ? 65  PHE A C   1 
ATOM   2816 O O   . PHE B 2 65  ? 141.312 148.768 82.960  1.00 49.76  ? 65  PHE A O   1 
ATOM   2817 C CB  . PHE B 2 65  ? 141.694 150.441 80.439  1.00 49.76  ? 65  PHE A CB  1 
ATOM   2818 C CG  . PHE B 2 65  ? 141.759 150.636 78.952  1.00 49.76  ? 65  PHE A CG  1 
ATOM   2819 C CD1 . PHE B 2 65  ? 142.768 151.396 78.383  1.00 49.76  ? 65  PHE A CD1 1 
ATOM   2820 C CD2 . PHE B 2 65  ? 140.810 150.064 78.122  1.00 49.76  ? 65  PHE A CD2 1 
ATOM   2821 C CE1 . PHE B 2 65  ? 142.830 151.579 77.015  1.00 49.76  ? 65  PHE A CE1 1 
ATOM   2822 C CE2 . PHE B 2 65  ? 140.866 150.243 76.752  1.00 49.76  ? 65  PHE A CE2 1 
ATOM   2823 C CZ  . PHE B 2 65  ? 141.878 151.002 76.199  1.00 49.76  ? 65  PHE A CZ  1 
ATOM   2824 N N   . HIS B 2 66  ? 143.471 149.419 83.166  1.00 35.27  ? 66  HIS A N   1 
ATOM   2825 C CA  . HIS B 2 66  ? 143.496 149.465 84.624  1.00 35.27  ? 66  HIS A CA  1 
ATOM   2826 C C   . HIS B 2 66  ? 143.794 150.901 85.033  1.00 35.27  ? 66  HIS A C   1 
ATOM   2827 O O   . HIS B 2 66  ? 144.916 151.384 84.838  1.00 35.27  ? 66  HIS A O   1 
ATOM   2828 C CB  . HIS B 2 66  ? 144.537 148.499 85.188  1.00 35.27  ? 66  HIS A CB  1 
ATOM   2829 C CG  . HIS B 2 66  ? 144.738 148.620 86.666  1.00 35.27  ? 66  HIS A CG  1 
ATOM   2830 N ND1 . HIS B 2 66  ? 143.719 148.430 87.575  1.00 35.27  ? 66  HIS A ND1 1 
ATOM   2831 C CD2 . HIS B 2 66  ? 145.842 148.910 87.395  1.00 35.27  ? 66  HIS A CD2 1 
ATOM   2832 C CE1 . HIS B 2 66  ? 144.186 148.598 88.799  1.00 35.27  ? 66  HIS A CE1 1 
ATOM   2833 N NE2 . HIS B 2 66  ? 145.471 148.891 88.717  1.00 35.27  ? 66  HIS A NE2 1 
ATOM   2834 N N   . ASN B 2 67  ? 142.790 151.580 85.592  1.00 31.74  ? 67  ASN A N   1 
ATOM   2835 C CA  . ASN B 2 67  ? 142.885 152.999 85.941  1.00 31.74  ? 67  ASN A CA  1 
ATOM   2836 C C   . ASN B 2 67  ? 143.244 153.855 84.730  1.00 31.74  ? 67  ASN A C   1 
ATOM   2837 O O   . ASN B 2 67  ? 143.950 154.858 84.852  1.00 31.74  ? 67  ASN A O   1 
ATOM   2838 C CB  . ASN B 2 67  ? 143.888 153.234 87.076  1.00 31.74  ? 67  ASN A CB  1 
ATOM   2839 C CG  . ASN B 2 67  ? 143.475 152.562 88.369  1.00 31.74  ? 67  ASN A CG  1 
ATOM   2840 O OD1 . ASN B 2 67  ? 142.687 151.616 88.368  1.00 31.74  ? 67  ASN A OD1 1 
ATOM   2841 N ND2 . ASN B 2 67  ? 144.007 153.049 89.485  1.00 31.74  ? 67  ASN A ND2 1 
ATOM   2842 N N   . GLY B 2 68  ? 142.761 153.464 83.550  1.00 40.57  ? 68  GLY A N   1 
ATOM   2843 C CA  . GLY B 2 68  ? 143.031 154.180 82.326  1.00 40.57  ? 68  GLY A CA  1 
ATOM   2844 C C   . GLY B 2 68  ? 144.315 153.792 81.623  1.00 40.57  ? 68  GLY A C   1 
ATOM   2845 O O   . GLY B 2 68  ? 144.591 154.314 80.537  1.00 40.57  ? 68  GLY A O   1 
ATOM   2846 N N   . SER B 2 69  ? 145.107 152.896 82.206  1.00 43.60  ? 69  SER A N   1 
ATOM   2847 C CA  . SER B 2 69  ? 146.372 152.482 81.617  1.00 43.60  ? 69  SER A CA  1 
ATOM   2848 C C   . SER B 2 69  ? 146.234 151.112 80.966  1.00 43.60  ? 69  SER A C   1 
ATOM   2849 O O   . SER B 2 69  ? 145.683 150.180 81.558  1.00 43.60  ? 69  SER A O   1 
ATOM   2850 C CB  . SER B 2 69  ? 147.474 152.447 82.677  1.00 43.60  ? 69  SER A CB  1 
ATOM   2851 O OG  . SER B 2 69  ? 147.157 151.532 83.712  1.00 43.60  ? 69  SER A OG  1 
ATOM   2852 N N   . LEU B 2 70  ? 146.739 151.000 79.739  1.00 53.08  ? 70  LEU A N   1 
ATOM   2853 C CA  . LEU B 2 70  ? 146.683 149.737 79.016  1.00 53.08  ? 70  LEU A CA  1 
ATOM   2854 C C   . LEU B 2 70  ? 147.582 148.700 79.679  1.00 53.08  ? 70  LEU A C   1 
ATOM   2855 O O   . LEU B 2 70  ? 148.698 149.004 80.109  1.00 53.08  ? 70  LEU A O   1 
ATOM   2856 C CB  . LEU B 2 70  ? 147.100 149.942 77.560  1.00 53.08  ? 70  LEU A CB  1 
ATOM   2857 C CG  . LEU B 2 70  ? 147.077 148.714 76.647  1.00 53.08  ? 70  LEU A CG  1 
ATOM   2858 C CD1 . LEU B 2 70  ? 145.664 148.170 76.508  1.00 53.08  ? 70  LEU A CD1 1 
ATOM   2859 C CD2 . LEU B 2 70  ? 147.665 149.045 75.284  1.00 53.08  ? 70  LEU A CD2 1 
ATOM   2860 N N   . SER B 2 71  ? 147.088 147.468 79.760  1.00 59.37  ? 71  SER A N   1 
ATOM   2861 C CA  . SER B 2 71  ? 147.822 146.368 80.361  1.00 59.37  ? 71  SER A CA  1 
ATOM   2862 C C   . SER B 2 71  ? 148.404 145.469 79.273  1.00 59.37  ? 71  SER A C   1 
ATOM   2863 O O   . SER B 2 71  ? 148.247 145.712 78.073  1.00 59.37  ? 71  SER A O   1 
ATOM   2864 C CB  . SER B 2 71  ? 146.918 145.576 81.308  1.00 59.37  ? 71  SER A CB  1 
ATOM   2865 O OG  . SER B 2 71  ? 145.829 145.000 80.610  1.00 59.37  ? 71  SER A OG  1 
ATOM   2866 N N   . GLU B 2 72  ? 149.088 144.410 79.704  1.00 68.33  ? 72  GLU A N   1 
ATOM   2867 C CA  . GLU B 2 72  ? 149.723 143.473 78.787  1.00 68.33  ? 72  GLU A CA  1 
ATOM   2868 C C   . GLU B 2 72  ? 148.775 142.396 78.278  1.00 68.33  ? 72  GLU A C   1 
ATOM   2869 O O   . GLU B 2 72  ? 149.139 141.662 77.352  1.00 68.33  ? 72  GLU A O   1 
ATOM   2870 C CB  . GLU B 2 72  ? 150.930 142.807 79.459  1.00 68.33  ? 72  GLU A CB  1 
ATOM   2871 C CG  . GLU B 2 72  ? 150.582 141.877 80.617  1.00 68.33  ? 72  GLU A CG  1 
ATOM   2872 C CD  . GLU B 2 72  ? 150.250 142.622 81.897  1.00 68.33  ? 72  GLU A CD  1 
ATOM   2873 O OE1 . GLU B 2 72  ? 150.465 143.852 81.946  1.00 68.33  ? 72  GLU A OE1 1 
ATOM   2874 O OE2 . GLU B 2 72  ? 149.773 141.977 82.854  1.00 68.33  ? 72  GLU A OE2 1 
ATOM   2875 N N   . GLU B 2 73  ? 147.580 142.279 78.852  1.00 66.28  ? 73  GLU A N   1 
ATOM   2876 C CA  . GLU B 2 73  ? 146.636 141.262 78.412  1.00 66.28  ? 73  GLU A CA  1 
ATOM   2877 C C   . GLU B 2 73  ? 146.082 141.603 77.034  1.00 66.28  ? 73  GLU A C   1 
ATOM   2878 O O   . GLU B 2 73  ? 145.749 142.756 76.746  1.00 66.28  ? 73  GLU A O   1 
ATOM   2879 C CB  . GLU B 2 73  ? 145.495 141.122 79.419  1.00 66.28  ? 73  GLU A CB  1 
ATOM   2880 C CG  . GLU B 2 73  ? 144.476 140.051 79.061  1.00 66.28  ? 73  GLU A CG  1 
ATOM   2881 C CD  . GLU B 2 73  ? 145.079 138.659 79.019  1.00 66.28  ? 73  GLU A CD  1 
ATOM   2882 O OE1 . GLU B 2 73  ? 146.025 138.393 79.791  1.00 66.28  ? 73  GLU A OE1 1 
ATOM   2883 O OE2 . GLU B 2 73  ? 144.609 137.831 78.211  1.00 66.28  ? 73  GLU A OE2 1 
ATOM   2884 N N   . THR B 2 74  ? 145.983 140.587 76.180  1.00 79.02  ? 74  THR A N   1 
ATOM   2885 C CA  . THR B 2 74  ? 145.470 140.747 74.827  1.00 79.02  ? 74  THR A CA  1 
ATOM   2886 C C   . THR B 2 74  ? 144.194 139.963 74.561  1.00 79.02  ? 74  THR A C   1 
ATOM   2887 O O   . THR B 2 74  ? 143.328 140.451 73.831  1.00 79.02  ? 74  THR A O   1 
ATOM   2888 C CB  . THR B 2 74  ? 146.534 140.328 73.799  1.00 79.02  ? 74  THR A CB  1 
ATOM   2889 O OG1 . THR B 2 74  ? 147.787 140.939 74.131  1.00 79.02  ? 74  THR A OG1 1 
ATOM   2890 C CG2 . THR B 2 74  ? 146.130 140.760 72.398  1.00 79.02  ? 74  THR A CG2 1 
ATOM   2891 N N   . ASN B 2 75  ? 144.047 138.773 75.139  1.00 74.43  ? 75  ASN A N   1 
ATOM   2892 C CA  . ASN B 2 75  ? 142.862 137.960 74.921  1.00 74.43  ? 75  ASN A CA  1 
ATOM   2893 C C   . ASN B 2 75  ? 141.673 138.521 75.699  1.00 74.43  ? 75  ASN A C   1 
ATOM   2894 O O   . ASN B 2 75  ? 141.807 139.404 76.551  1.00 74.43  ? 75  ASN A O   1 
ATOM   2895 C CB  . ASN B 2 75  ? 143.128 136.510 75.323  1.00 74.43  ? 75  ASN A CB  1 
ATOM   2896 C CG  . ASN B 2 75  ? 144.227 135.870 74.499  1.00 74.43  ? 75  ASN A CG  1 
ATOM   2897 O OD1 . ASN B 2 75  ? 145.047 136.560 73.893  1.00 74.43  ? 75  ASN A OD1 1 
ATOM   2898 N ND2 . ASN B 2 75  ? 144.250 134.542 74.471  1.00 74.43  ? 75  ASN A ND2 1 
ATOM   2899 N N   . SER B 2 76  ? 140.488 137.991 75.390  1.00 72.93  ? 76  SER A N   1 
ATOM   2900 C CA  . SER B 2 76  ? 139.258 138.453 76.023  1.00 72.93  ? 76  SER A CA  1 
ATOM   2901 C C   . SER B 2 76  ? 139.133 138.012 77.476  1.00 72.93  ? 76  SER A C   1 
ATOM   2902 O O   . SER B 2 76  ? 138.260 138.525 78.184  1.00 72.93  ? 76  SER A O   1 
ATOM   2903 C CB  . SER B 2 76  ? 138.045 137.961 75.232  1.00 72.93  ? 76  SER A CB  1 
ATOM   2904 O OG  . SER B 2 76  ? 137.988 136.545 75.215  1.00 72.93  ? 76  SER A OG  1 
ATOM   2905 N N   . SER B 2 77  ? 139.966 137.083 77.933  1.00 63.86  ? 77  SER A N   1 
ATOM   2906 C CA  . SER B 2 77  ? 139.930 136.594 79.304  1.00 63.86  ? 77  SER A CA  1 
ATOM   2907 C C   . SER B 2 77  ? 141.198 137.021 80.029  1.00 63.86  ? 77  SER A C   1 
ATOM   2908 O O   . SER B 2 77  ? 142.308 136.756 79.555  1.00 63.86  ? 77  SER A O   1 
ATOM   2909 C CB  . SER B 2 77  ? 139.787 135.071 79.339  1.00 63.86  ? 77  SER A CB  1 
ATOM   2910 O OG  . SER B 2 77  ? 140.876 134.441 78.687  1.00 63.86  ? 77  SER A OG  1 
ATOM   2911 N N   . LEU B 2 78  ? 141.030 137.678 81.174  1.00 51.67  ? 78  LEU A N   1 
ATOM   2912 C CA  . LEU B 2 78  ? 142.144 138.140 81.991  1.00 51.67  ? 78  LEU A CA  1 
ATOM   2913 C C   . LEU B 2 78  ? 142.133 137.402 83.321  1.00 51.67  ? 78  LEU A C   1 
ATOM   2914 O O   . LEU B 2 78  ? 141.126 137.420 84.035  1.00 51.67  ? 78  LEU A O   1 
ATOM   2915 C CB  . LEU B 2 78  ? 142.069 139.652 82.223  1.00 51.67  ? 78  LEU A CB  1 
ATOM   2916 C CG  . LEU B 2 78  ? 143.070 140.240 83.220  1.00 51.67  ? 78  LEU A CG  1 
ATOM   2917 C CD1 . LEU B 2 78  ? 144.500 139.961 82.784  1.00 51.67  ? 78  LEU A CD1 1 
ATOM   2918 C CD2 . LEU B 2 78  ? 142.841 141.734 83.393  1.00 51.67  ? 78  LEU A CD2 1 
ATOM   2919 N N   . ASN B 2 79  ? 143.249 136.763 83.655  1.00 42.10  ? 79  ASN A N   1 
ATOM   2920 C CA  . ASN B 2 79  ? 143.381 135.999 84.888  1.00 42.10  ? 79  ASN A CA  1 
ATOM   2921 C C   . ASN B 2 79  ? 144.304 136.736 85.847  1.00 42.10  ? 79  ASN A C   1 
ATOM   2922 O O   . ASN B 2 79  ? 145.401 137.154 85.461  1.00 42.10  ? 79  ASN A O   1 
ATOM   2923 C CB  . ASN B 2 79  ? 143.922 134.595 84.609  1.00 42.10  ? 79  ASN A CB  1 
ATOM   2924 C CG  . ASN B 2 79  ? 142.997 133.776 83.731  1.00 42.10  ? 79  ASN A CG  1 
ATOM   2925 O OD1 . ASN B 2 79  ? 142.138 134.319 83.036  1.00 42.10  ? 79  ASN A OD1 1 
ATOM   2926 N ND2 . ASN B 2 79  ? 143.168 132.459 83.758  1.00 42.10  ? 79  ASN A ND2 1 
ATOM   2927 N N   . ILE B 2 80  ? 143.861 136.893 87.092  1.00 34.88  ? 80  ILE A N   1 
ATOM   2928 C CA  . ILE B 2 80  ? 144.660 137.511 88.144  1.00 34.88  ? 80  ILE A CA  1 
ATOM   2929 C C   . ILE B 2 80  ? 144.893 136.466 89.224  1.00 34.88  ? 80  ILE A C   1 
ATOM   2930 O O   . ILE B 2 80  ? 143.934 135.913 89.781  1.00 34.88  ? 80  ILE A O   1 
ATOM   2931 C CB  . ILE B 2 80  ? 143.981 138.762 88.724  1.00 34.88  ? 80  ILE A CB  1 
ATOM   2932 C CG1 . ILE B 2 80  ? 143.760 139.806 87.628  1.00 34.88  ? 80  ILE A CG1 1 
ATOM   2933 C CG2 . ILE B 2 80  ? 144.813 139.341 89.859  1.00 34.88  ? 80  ILE A CG2 1 
ATOM   2934 C CD1 . ILE B 2 80  ? 143.076 141.066 88.114  1.00 34.88  ? 80  ILE A CD1 1 
ATOM   2935 N N   . VAL B 2 81  ? 146.164 136.201 89.518  1.00 35.79  ? 81  VAL A N   1 
ATOM   2936 C CA  . VAL B 2 81  ? 146.576 135.206 90.501  1.00 35.79  ? 81  VAL A CA  1 
ATOM   2937 C C   . VAL B 2 81  ? 147.338 135.921 91.607  1.00 35.79  ? 81  VAL A C   1 
ATOM   2938 O O   . VAL B 2 81  ? 148.236 136.724 91.327  1.00 35.79  ? 81  VAL A O   1 
ATOM   2939 C CB  . VAL B 2 81  ? 147.442 134.105 89.861  1.00 35.79  ? 81  VAL A CB  1 
ATOM   2940 C CG1 . VAL B 2 81  ? 148.037 133.202 90.930  1.00 35.79  ? 81  VAL A CG1 1 
ATOM   2941 C CG2 . VAL B 2 81  ? 146.622 133.297 88.867  1.00 35.79  ? 81  VAL A CG2 1 
ATOM   2942 N N   . ASN B 2 82  ? 146.974 135.631 92.858  1.00 34.65  ? 82  ASN A N   1 
ATOM   2943 C CA  . ASN B 2 82  ? 147.581 136.255 94.033  1.00 34.65  ? 82  ASN A CA  1 
ATOM   2944 C C   . ASN B 2 82  ? 147.420 137.776 93.977  1.00 34.65  ? 82  ASN A C   1 
ATOM   2945 O O   . ASN B 2 82  ? 148.389 138.536 93.908  1.00 34.65  ? 82  ASN A O   1 
ATOM   2946 C CB  . ASN B 2 82  ? 149.053 135.850 94.175  1.00 34.65  ? 82  ASN A CB  1 
ATOM   2947 C CG  . ASN B 2 82  ? 149.657 136.291 95.494  1.00 34.65  ? 82  ASN A CG  1 
ATOM   2948 O OD1 . ASN B 2 82  ? 148.942 136.554 96.461  1.00 34.65  ? 82  ASN A OD1 1 
ATOM   2949 N ND2 . ASN B 2 82  ? 150.982 136.375 95.540  1.00 34.65  ? 82  ASN A ND2 1 
ATOM   2950 N N   . ALA B 2 83  ? 146.161 138.207 93.998  1.00 30.52  ? 83  ALA A N   1 
ATOM   2951 C CA  . ALA B 2 83  ? 145.848 139.625 93.895  1.00 30.52  ? 83  ALA A CA  1 
ATOM   2952 C C   . ALA B 2 83  ? 146.320 140.380 95.131  1.00 30.52  ? 83  ALA A C   1 
ATOM   2953 O O   . ALA B 2 83  ? 146.191 139.901 96.261  1.00 30.52  ? 83  ALA A O   1 
ATOM   2954 C CB  . ALA B 2 83  ? 144.345 139.823 93.701  1.00 30.52  ? 83  ALA A CB  1 
ATOM   2955 N N   . LYS B 2 84  ? 146.869 141.569 94.908  1.00 26.89  ? 84  LYS A N   1 
ATOM   2956 C CA  . LYS B 2 84  ? 147.331 142.453 95.967  1.00 26.89  ? 84  LYS A CA  1 
ATOM   2957 C C   . LYS B 2 84  ? 146.407 143.663 96.064  1.00 26.89  ? 84  LYS A C   1 
ATOM   2958 O O   . LYS B 2 84  ? 145.382 143.753 95.381  1.00 26.89  ? 84  LYS A O   1 
ATOM   2959 C CB  . LYS B 2 84  ? 148.779 142.888 95.722  1.00 26.89  ? 84  LYS A CB  1 
ATOM   2960 C CG  . LYS B 2 84  ? 149.777 141.747 95.583  1.00 26.89  ? 84  LYS A CG  1 
ATOM   2961 C CD  . LYS B 2 84  ? 150.011 141.383 94.124  1.00 26.89  ? 84  LYS A CD  1 
ATOM   2962 C CE  . LYS B 2 84  ? 151.096 140.329 93.984  1.00 26.89  ? 84  LYS A CE  1 
ATOM   2963 N NZ  . LYS B 2 84  ? 151.332 139.963 92.559  1.00 26.89  ? 84  LYS A NZ  1 
ATOM   2964 N N   . PHE B 2 85  ? 146.781 144.606 96.934  1.00 24.01  ? 85  PHE A N   1 
ATOM   2965 C CA  . PHE B 2 85  ? 145.999 145.830 97.073  1.00 24.01  ? 85  PHE A CA  1 
ATOM   2966 C C   . PHE B 2 85  ? 146.096 146.706 95.830  1.00 24.01  ? 85  PHE A C   1 
ATOM   2967 O O   . PHE B 2 85  ? 145.148 147.435 95.514  1.00 24.01  ? 85  PHE A O   1 
ATOM   2968 C CB  . PHE B 2 85  ? 146.451 146.611 98.307  1.00 24.01  ? 85  PHE A CB  1 
ATOM   2969 C CG  . PHE B 2 85  ? 146.053 145.975 99.607  1.00 24.01  ? 85  PHE A CG  1 
ATOM   2970 C CD1 . PHE B 2 85  ? 144.763 146.110 100.092 1.00 24.01  ? 85  PHE A CD1 1 
ATOM   2971 C CD2 . PHE B 2 85  ? 146.969 145.247 100.349 1.00 24.01  ? 85  PHE A CD2 1 
ATOM   2972 C CE1 . PHE B 2 85  ? 144.392 145.528 101.290 1.00 24.01  ? 85  PHE A CE1 1 
ATOM   2973 C CE2 . PHE B 2 85  ? 146.605 144.664 101.548 1.00 24.01  ? 85  PHE A CE2 1 
ATOM   2974 C CZ  . PHE B 2 85  ? 145.314 144.804 102.018 1.00 24.01  ? 85  PHE A CZ  1 
ATOM   2975 N N   . GLU B 2 86  ? 147.225 146.654 95.119  1.00 27.04  ? 86  GLU A N   1 
ATOM   2976 C CA  . GLU B 2 86  ? 147.387 147.463 93.916  1.00 27.04  ? 86  GLU A CA  1 
ATOM   2977 C C   . GLU B 2 86  ? 146.444 147.037 92.798  1.00 27.04  ? 86  GLU A C   1 
ATOM   2978 O O   . GLU B 2 86  ? 146.138 147.851 91.920  1.00 27.04  ? 86  GLU A O   1 
ATOM   2979 C CB  . GLU B 2 86  ? 148.834 147.398 93.421  1.00 27.04  ? 86  GLU A CB  1 
ATOM   2980 C CG  . GLU B 2 86  ? 149.854 148.038 94.355  1.00 27.04  ? 86  GLU A CG  1 
ATOM   2981 C CD  . GLU B 2 86  ? 150.232 147.142 95.519  1.00 27.04  ? 86  GLU A CD  1 
ATOM   2982 O OE1 . GLU B 2 86  ? 149.874 145.946 95.492  1.00 27.04  ? 86  GLU A OE1 1 
ATOM   2983 O OE2 . GLU B 2 86  ? 150.886 147.634 96.462  1.00 27.04  ? 86  GLU A OE2 1 
ATOM   2984 N N   . ASP B 2 87  ? 145.977 145.787 92.809  1.00 26.20  ? 87  ASP A N   1 
ATOM   2985 C CA  . ASP B 2 87  ? 145.049 145.320 91.787  1.00 26.20  ? 87  ASP A CA  1 
ATOM   2986 C C   . ASP B 2 87  ? 143.646 145.886 91.958  1.00 26.20  ? 87  ASP A C   1 
ATOM   2987 O O   . ASP B 2 87  ? 142.833 145.762 91.036  1.00 26.20  ? 87  ASP A O   1 
ATOM   2988 C CB  . ASP B 2 87  ? 144.995 143.791 91.786  1.00 26.20  ? 87  ASP A CB  1 
ATOM   2989 C CG  . ASP B 2 87  ? 146.312 143.163 91.377  1.00 26.20  ? 87  ASP A CG  1 
ATOM   2990 O OD1 . ASP B 2 87  ? 147.047 143.785 90.581  1.00 26.20  ? 87  ASP A OD1 1 
ATOM   2991 O OD2 . ASP B 2 87  ? 146.614 142.048 91.850  1.00 26.20  ? 87  ASP A OD2 1 
ATOM   2992 N N   . SER B 2 88  ? 143.343 146.494 93.101  1.00 22.84  ? 88  SER A N   1 
ATOM   2993 C CA  . SER B 2 88  ? 142.037 147.100 93.302  1.00 22.84  ? 88  SER A CA  1 
ATOM   2994 C C   . SER B 2 88  ? 141.880 148.335 92.420  1.00 22.84  ? 88  SER A C   1 
ATOM   2995 O O   . SER B 2 88  ? 142.856 148.956 91.990  1.00 22.84  ? 88  SER A O   1 
ATOM   2996 C CB  . SER B 2 88  ? 141.839 147.475 94.771  1.00 22.84  ? 88  SER A CB  1 
ATOM   2997 O OG  . SER B 2 88  ? 141.948 146.337 95.608  1.00 22.84  ? 88  SER A OG  1 
ATOM   2998 N N   . GLY B 2 89  ? 140.625 148.685 92.144  1.00 24.91  ? 89  GLY A N   1 
ATOM   2999 C CA  . GLY B 2 89  ? 140.302 149.838 91.337  1.00 24.91  ? 89  GLY A CA  1 
ATOM   3000 C C   . GLY B 2 89  ? 139.318 149.471 90.250  1.00 24.91  ? 89  GLY A C   1 
ATOM   3001 O O   . GLY B 2 89  ? 138.588 148.479 90.351  1.00 24.91  ? 89  GLY A O   1 
ATOM   3002 N N   . GLU B 2 90  ? 139.307 150.278 89.193  1.00 30.89  ? 90  GLU A N   1 
ATOM   3003 C CA  . GLU B 2 90  ? 138.376 150.108 88.087  1.00 30.89  ? 90  GLU A CA  1 
ATOM   3004 C C   . GLU B 2 90  ? 139.046 149.345 86.951  1.00 30.89  ? 90  GLU A C   1 
ATOM   3005 O O   . GLU B 2 90  ? 140.178 149.655 86.566  1.00 30.89  ? 90  GLU A O   1 
ATOM   3006 C CB  . GLU B 2 90  ? 137.862 151.462 87.589  1.00 30.89  ? 90  GLU A CB  1 
ATOM   3007 C CG  . GLU B 2 90  ? 138.944 152.480 87.243  1.00 30.89  ? 90  GLU A CG  1 
ATOM   3008 C CD  . GLU B 2 90  ? 139.461 153.228 88.458  1.00 30.89  ? 90  GLU A CD  1 
ATOM   3009 O OE1 . GLU B 2 90  ? 138.925 153.011 89.565  1.00 30.89  ? 90  GLU A OE1 1 
ATOM   3010 O OE2 . GLU B 2 90  ? 140.402 154.034 88.305  1.00 30.89  ? 90  GLU A OE2 1 
ATOM   3011 N N   . TYR B 2 91  ? 138.345 148.343 86.429  1.00 32.73  ? 91  TYR A N   1 
ATOM   3012 C CA  . TYR B 2 91  ? 138.781 147.567 85.280  1.00 32.73  ? 91  TYR A CA  1 
ATOM   3013 C C   . TYR B 2 91  ? 137.874 147.870 84.096  1.00 32.73  ? 91  TYR A C   1 
ATOM   3014 O O   . TYR B 2 91  ? 136.653 147.994 84.254  1.00 32.73  ? 91  TYR A O   1 
ATOM   3015 C CB  . TYR B 2 91  ? 138.755 146.066 85.584  1.00 32.73  ? 91  TYR A CB  1 
ATOM   3016 C CG  . TYR B 2 91  ? 139.816 145.610 86.559  1.00 32.73  ? 91  TYR A CG  1 
ATOM   3017 C CD1 . TYR B 2 91  ? 141.118 146.081 86.471  1.00 32.73  ? 91  TYR A CD1 1 
ATOM   3018 C CD2 . TYR B 2 91  ? 139.513 144.707 87.570  1.00 32.73  ? 91  TYR A CD2 1 
ATOM   3019 C CE1 . TYR B 2 91  ? 142.090 145.664 87.360  1.00 32.73  ? 91  TYR A CE1 1 
ATOM   3020 C CE2 . TYR B 2 91  ? 140.477 144.285 88.463  1.00 32.73  ? 91  TYR A CE2 1 
ATOM   3021 C CZ  . TYR B 2 91  ? 141.763 144.766 88.353  1.00 32.73  ? 91  TYR A CZ  1 
ATOM   3022 O OH  . TYR B 2 91  ? 142.727 144.348 89.242  1.00 32.73  ? 91  TYR A OH  1 
ATOM   3023 N N   . LYS B 2 92  ? 138.474 147.994 82.913  1.00 47.91  ? 92  LYS A N   1 
ATOM   3024 C CA  . LYS B 2 92  ? 137.733 148.297 81.699  1.00 47.91  ? 92  LYS A CA  1 
ATOM   3025 C C   . LYS B 2 92  ? 138.224 147.391 80.580  1.00 47.91  ? 92  LYS A C   1 
ATOM   3026 O O   . LYS B 2 92  ? 139.410 147.061 80.523  1.00 47.91  ? 92  LYS A O   1 
ATOM   3027 C CB  . LYS B 2 92  ? 137.906 149.771 81.314  1.00 47.91  ? 92  LYS A CB  1 
ATOM   3028 C CG  . LYS B 2 92  ? 137.096 150.223 80.117  1.00 47.91  ? 92  LYS A CG  1 
ATOM   3029 C CD  . LYS B 2 92  ? 137.341 151.696 79.839  1.00 47.91  ? 92  LYS A CD  1 
ATOM   3030 C CE  . LYS B 2 92  ? 136.917 152.558 81.017  1.00 47.91  ? 92  LYS A CE  1 
ATOM   3031 N NZ  . LYS B 2 92  ? 135.466 152.412 81.317  1.00 47.91  ? 92  LYS A NZ  1 
ATOM   3032 N N   . CYS B 2 93  ? 137.317 146.987 79.695  1.00 59.23  ? 93  CYS A N   1 
ATOM   3033 C CA  . CYS B 2 93  ? 137.680 146.169 78.545  1.00 59.23  ? 93  CYS A CA  1 
ATOM   3034 C C   . CYS B 2 93  ? 137.034 146.744 77.294  1.00 59.23  ? 93  CYS A C   1 
ATOM   3035 O O   . CYS B 2 93  ? 135.854 147.111 77.311  1.00 59.23  ? 93  CYS A O   1 
ATOM   3036 C CB  . CYS B 2 93  ? 137.273 144.703 78.749  1.00 59.23  ? 93  CYS A CB  1 
ATOM   3037 S SG  . CYS B 2 93  ? 135.499 144.354 78.755  1.00 59.23  ? 93  CYS A SG  1 
ATOM   3038 N N   . GLN B 2 94  ? 137.812 146.832 76.218  1.00 72.28  ? 94  GLN A N   1 
ATOM   3039 C CA  . GLN B 2 94  ? 137.357 147.378 74.949  1.00 72.28  ? 94  GLN A CA  1 
ATOM   3040 C C   . GLN B 2 94  ? 137.646 146.384 73.833  1.00 72.28  ? 94  GLN A C   1 
ATOM   3041 O O   . GLN B 2 94  ? 138.699 145.739 73.820  1.00 72.28  ? 94  GLN A O   1 
ATOM   3042 C CB  . GLN B 2 94  ? 138.038 148.721 74.651  1.00 72.28  ? 94  GLN A CB  1 
ATOM   3043 C CG  . GLN B 2 94  ? 137.558 149.401 73.380  1.00 72.28  ? 94  GLN A CG  1 
ATOM   3044 C CD  . GLN B 2 94  ? 138.270 150.714 73.116  1.00 72.28  ? 94  GLN A CD  1 
ATOM   3045 O OE1 . GLN B 2 94  ? 139.130 151.134 73.890  1.00 72.28  ? 94  GLN A OE1 1 
ATOM   3046 N NE2 . GLN B 2 94  ? 137.913 151.369 72.018  1.00 72.28  ? 94  GLN A NE2 1 
ATOM   3047 N N   . HIS B 2 95  ? 136.702 146.250 72.904  1.00 96.39  ? 95  HIS A N   1 
ATOM   3048 C CA  . HIS B 2 95  ? 136.848 145.347 71.771  1.00 96.39  ? 95  HIS A CA  1 
ATOM   3049 C C   . HIS B 2 95  ? 136.497 146.078 70.485  1.00 96.39  ? 95  HIS A C   1 
ATOM   3050 O O   . HIS B 2 95  ? 135.469 146.760 70.416  1.00 96.39  ? 95  HIS A O   1 
ATOM   3051 C CB  . HIS B 2 95  ? 135.964 144.107 71.925  1.00 96.39  ? 95  HIS A CB  1 
ATOM   3052 C CG  . HIS B 2 95  ? 135.973 143.214 70.724  1.00 96.39  ? 95  HIS A CG  1 
ATOM   3053 N ND1 . HIS B 2 95  ? 137.120 142.613 70.254  1.00 96.39  ? 95  HIS A ND1 1 
ATOM   3054 C CD2 . HIS B 2 95  ? 134.979 142.833 69.888  1.00 96.39  ? 95  HIS A CD2 1 
ATOM   3055 C CE1 . HIS B 2 95  ? 136.832 141.894 69.184  1.00 96.39  ? 95  HIS A CE1 1 
ATOM   3056 N NE2 . HIS B 2 95  ? 135.539 142.010 68.941  1.00 96.39  ? 95  HIS A NE2 1 
ATOM   3057 N N   . GLN B 2 96  ? 137.346 145.926 69.474  1.00 90.85  ? 96  GLN A N   1 
ATOM   3058 C CA  . GLN B 2 96  ? 137.139 146.509 68.137  1.00 90.85  ? 96  GLN A CA  1 
ATOM   3059 C C   . GLN B 2 96  ? 137.026 148.028 68.307  1.00 90.85  ? 96  GLN A C   1 
ATOM   3060 O O   . GLN B 2 96  ? 137.753 148.614 69.125  1.00 90.85  ? 96  GLN A O   1 
ATOM   3061 C CB  . GLN B 2 96  ? 135.951 145.837 67.468  1.00 90.85  ? 96  GLN A CB  1 
ATOM   3062 C CG  . GLN B 2 96  ? 135.965 145.887 65.944  1.00 90.85  ? 96  GLN A CG  1 
ATOM   3063 C CD  . GLN B 2 96  ? 134.979 146.892 65.374  1.00 90.85  ? 96  GLN A CD  1 
ATOM   3064 O OE1 . GLN B 2 96  ? 134.237 147.541 66.112  1.00 90.85  ? 96  GLN A OE1 1 
ATOM   3065 N NE2 . GLN B 2 96  ? 134.969 147.025 64.053  1.00 90.85  ? 96  GLN A NE2 1 
ATOM   3066 N N   . GLN B 2 97  ? 136.145 148.692 67.563  1.00 94.45  ? 97  GLN A N   1 
ATOM   3067 C CA  . GLN B 2 97  ? 135.977 150.136 67.634  1.00 94.45  ? 97  GLN A CA  1 
ATOM   3068 C C   . GLN B 2 97  ? 134.779 150.548 68.481  1.00 94.45  ? 97  GLN A C   1 
ATOM   3069 O O   . GLN B 2 97  ? 134.431 151.733 68.509  1.00 94.45  ? 97  GLN A O   1 
ATOM   3070 C CB  . GLN B 2 97  ? 135.848 150.719 66.225  1.00 94.45  ? 97  GLN A CB  1 
ATOM   3071 C CG  . GLN B 2 97  ? 136.954 150.293 65.269  1.00 94.45  ? 97  GLN A CG  1 
ATOM   3072 C CD  . GLN B 2 97  ? 138.335 150.702 65.747  1.00 94.45  ? 97  GLN A CD  1 
ATOM   3073 O OE1 . GLN B 2 97  ? 138.496 151.714 66.429  1.00 94.45  ? 97  GLN A OE1 1 
ATOM   3074 N NE2 . GLN B 2 97  ? 139.341 149.911 65.392  1.00 94.45  ? 97  GLN A NE2 1 
ATOM   3075 N N   . VAL B 2 98  ? 134.139 149.598 69.169  1.00 88.81  ? 98  VAL A N   1 
ATOM   3076 C CA  . VAL B 2 98  ? 132.977 149.936 69.985  1.00 88.81  ? 98  VAL A CA  1 
ATOM   3077 C C   . VAL B 2 98  ? 133.412 150.759 71.195  1.00 88.81  ? 98  VAL A C   1 
ATOM   3078 O O   . VAL B 2 98  ? 134.588 150.798 71.576  1.00 88.81  ? 98  VAL A O   1 
ATOM   3079 C CB  . VAL B 2 98  ? 132.216 148.669 70.415  1.00 88.81  ? 98  VAL A CB  1 
ATOM   3080 C CG1 . VAL B 2 98  ? 132.728 148.157 71.759  1.00 88.81  ? 98  VAL A CG1 1 
ATOM   3081 C CG2 . VAL B 2 98  ? 130.714 148.935 70.462  1.00 88.81  ? 98  VAL A CG2 1 
ATOM   3082 N N   . ASN B 2 99  ? 132.440 151.437 71.799  1.00 79.54  ? 99  ASN A N   1 
ATOM   3083 C CA  . ASN B 2 99  ? 132.718 152.283 72.949  1.00 79.54  ? 99  ASN A CA  1 
ATOM   3084 C C   . ASN B 2 99  ? 133.174 151.449 74.142  1.00 79.54  ? 99  ASN A C   1 
ATOM   3085 O O   . ASN B 2 99  ? 132.849 150.265 74.265  1.00 79.54  ? 99  ASN A O   1 
ATOM   3086 C CB  . ASN B 2 99  ? 131.482 153.100 73.321  1.00 79.54  ? 99  ASN A CB  1 
ATOM   3087 C CG  . ASN B 2 99  ? 131.065 154.056 72.221  1.00 79.54  ? 99  ASN A CG  1 
ATOM   3088 O OD1 . ASN B 2 99  ? 131.895 154.530 71.445  1.00 79.54  ? 99  ASN A OD1 1 
ATOM   3089 N ND2 . ASN B 2 99  ? 129.771 154.347 72.149  1.00 79.54  ? 99  ASN A ND2 1 
ATOM   3090 N N   . GLU B 2 100 ? 133.937 152.087 75.026  1.00 65.45  ? 100 GLU A N   1 
ATOM   3091 C CA  . GLU B 2 100 ? 134.508 151.399 76.173  1.00 65.45  ? 100 GLU A CA  1 
ATOM   3092 C C   . GLU B 2 100 ? 133.416 150.907 77.119  1.00 65.45  ? 100 GLU A C   1 
ATOM   3093 O O   . GLU B 2 100 ? 132.365 151.533 77.275  1.00 65.45  ? 100 GLU A O   1 
ATOM   3094 C CB  . GLU B 2 100 ? 135.469 152.323 76.918  1.00 65.45  ? 100 GLU A CB  1 
ATOM   3095 C CG  . GLU B 2 100 ? 136.692 152.728 76.109  1.00 65.45  ? 100 GLU A CG  1 
ATOM   3096 C CD  . GLU B 2 100 ? 137.585 153.706 76.848  1.00 65.45  ? 100 GLU A CD  1 
ATOM   3097 O OE1 . GLU B 2 100 ? 137.131 154.285 77.858  1.00 65.45  ? 100 GLU A OE1 1 
ATOM   3098 O OE2 . GLU B 2 100 ? 138.743 153.896 76.421  1.00 65.45  ? 100 GLU A OE2 1 
ATOM   3099 N N   . SER B 2 101 ? 133.681 149.768 77.756  1.00 56.08  ? 101 SER A N   1 
ATOM   3100 C CA  . SER B 2 101 ? 132.717 149.141 78.645  1.00 56.08  ? 101 SER A CA  1 
ATOM   3101 C C   . SER B 2 101 ? 132.703 149.842 80.002  1.00 56.08  ? 101 SER A C   1 
ATOM   3102 O O   . SER B 2 101 ? 133.428 150.811 80.245  1.00 56.08  ? 101 SER A O   1 
ATOM   3103 C CB  . SER B 2 101 ? 133.028 147.655 78.799  1.00 56.08  ? 101 SER A CB  1 
ATOM   3104 O OG  . SER B 2 101 ? 134.318 147.458 79.351  1.00 56.08  ? 101 SER A OG  1 
ATOM   3105 N N   . GLU B 2 102 ? 131.858 149.343 80.899  1.00 47.33  ? 102 GLU A N   1 
ATOM   3106 C CA  . GLU B 2 102 ? 131.743 149.934 82.223  1.00 47.33  ? 102 GLU A CA  1 
ATOM   3107 C C   . GLU B 2 102 ? 133.008 149.664 83.037  1.00 47.33  ? 102 GLU A C   1 
ATOM   3108 O O   . GLU B 2 102 ? 133.546 148.553 83.003  1.00 47.33  ? 102 GLU A O   1 
ATOM   3109 C CB  . GLU B 2 102 ? 130.524 149.375 82.956  1.00 47.33  ? 102 GLU A CB  1 
ATOM   3110 C CG  . GLU B 2 102 ? 129.203 149.590 82.230  1.00 47.33  ? 102 GLU A CG  1 
ATOM   3111 C CD  . GLU B 2 102 ? 128.772 151.044 82.210  1.00 47.33  ? 102 GLU A CD  1 
ATOM   3112 O OE1 . GLU B 2 102 ? 129.262 151.827 83.052  1.00 47.33  ? 102 GLU A OE1 1 
ATOM   3113 O OE2 . GLU B 2 102 ? 127.939 151.406 81.352  1.00 47.33  ? 102 GLU A OE2 1 
ATOM   3114 N N   . PRO B 2 103 ? 133.505 150.657 83.776  1.00 38.49  ? 103 PRO A N   1 
ATOM   3115 C CA  . PRO B 2 103 ? 134.674 150.426 84.636  1.00 38.49  ? 103 PRO A CA  1 
ATOM   3116 C C   . PRO B 2 103 ? 134.303 149.704 85.922  1.00 38.49  ? 103 PRO A C   1 
ATOM   3117 O O   . PRO B 2 103 ? 134.070 150.343 86.954  1.00 38.49  ? 103 PRO A O   1 
ATOM   3118 C CB  . PRO B 2 103 ? 135.189 151.843 84.910  1.00 38.49  ? 103 PRO A CB  1 
ATOM   3119 C CG  . PRO B 2 103 ? 133.968 152.700 84.818  1.00 38.49  ? 103 PRO A CG  1 
ATOM   3120 C CD  . PRO B 2 103 ? 133.084 152.069 83.773  1.00 38.49  ? 103 PRO A CD  1 
ATOM   3121 N N   . VAL B 2 104 ? 134.238 148.373 85.869  1.00 28.25  ? 104 VAL A N   1 
ATOM   3122 C CA  . VAL B 2 104 ? 133.800 147.595 87.023  1.00 28.25  ? 104 VAL A CA  1 
ATOM   3123 C C   . VAL B 2 104 ? 134.801 147.758 88.159  1.00 28.25  ? 104 VAL A C   1 
ATOM   3124 O O   . VAL B 2 104 ? 136.015 147.627 87.963  1.00 28.25  ? 104 VAL A O   1 
ATOM   3125 C CB  . VAL B 2 104 ? 133.622 146.118 86.640  1.00 28.25  ? 104 VAL A CB  1 
ATOM   3126 C CG1 . VAL B 2 104 ? 133.289 145.285 87.869  1.00 28.25  ? 104 VAL A CG1 1 
ATOM   3127 C CG2 . VAL B 2 104 ? 132.535 145.976 85.588  1.00 28.25  ? 104 VAL A CG2 1 
ATOM   3128 N N   . TYR B 2 105 ? 134.295 148.051 89.354  1.00 27.90  ? 105 TYR A N   1 
ATOM   3129 C CA  . TYR B 2 105 ? 135.139 148.319 90.511  1.00 27.90  ? 105 TYR A CA  1 
ATOM   3130 C C   . TYR B 2 105 ? 135.364 147.029 91.292  1.00 27.90  ? 105 TYR A C   1 
ATOM   3131 O O   . TYR B 2 105 ? 134.405 146.402 91.755  1.00 27.90  ? 105 TYR A O   1 
ATOM   3132 C CB  . TYR B 2 105 ? 134.504 149.382 91.406  1.00 27.90  ? 105 TYR A CB  1 
ATOM   3133 C CG  . TYR B 2 105 ? 134.140 150.658 90.682  1.00 27.90  ? 105 TYR A CG  1 
ATOM   3134 C CD1 . TYR B 2 105 ? 135.076 151.667 90.498  1.00 27.90  ? 105 TYR A CD1 1 
ATOM   3135 C CD2 . TYR B 2 105 ? 132.858 150.854 90.183  1.00 27.90  ? 105 TYR A CD2 1 
ATOM   3136 C CE1 . TYR B 2 105 ? 134.746 152.835 89.837  1.00 27.90  ? 105 TYR A CE1 1 
ATOM   3137 C CE2 . TYR B 2 105 ? 132.520 152.019 89.521  1.00 27.90  ? 105 TYR A CE2 1 
ATOM   3138 C CZ  . TYR B 2 105 ? 133.467 153.006 89.351  1.00 27.90  ? 105 TYR A CZ  1 
ATOM   3139 O OH  . TYR B 2 105 ? 133.135 154.167 88.692  1.00 27.90  ? 105 TYR A OH  1 
ATOM   3140 N N   . LEU B 2 106 ? 136.628 146.637 91.435  1.00 21.96  ? 106 LEU A N   1 
ATOM   3141 C CA  . LEU B 2 106 ? 137.017 145.475 92.225  1.00 21.96  ? 106 LEU A CA  1 
ATOM   3142 C C   . LEU B 2 106 ? 137.863 145.955 93.394  1.00 21.96  ? 106 LEU A C   1 
ATOM   3143 O O   . LEU B 2 106 ? 138.885 146.620 93.192  1.00 21.96  ? 106 LEU A O   1 
ATOM   3144 C CB  . LEU B 2 106 ? 137.789 144.464 91.374  1.00 21.96  ? 106 LEU A CB  1 
ATOM   3145 C CG  . LEU B 2 106 ? 138.264 143.191 92.078  1.00 21.96  ? 106 LEU A CG  1 
ATOM   3146 C CD1 . LEU B 2 106 ? 137.083 142.409 92.628  1.00 21.96  ? 106 LEU A CD1 1 
ATOM   3147 C CD2 . LEU B 2 106 ? 139.086 142.331 91.131  1.00 21.96  ? 106 LEU A CD2 1 
ATOM   3148 N N   . GLU B 2 107 ? 137.442 145.619 94.610  1.00 18.40  ? 107 GLU A N   1 
ATOM   3149 C CA  . GLU B 2 107 ? 138.108 146.069 95.823  1.00 18.40  ? 107 GLU A CA  1 
ATOM   3150 C C   . GLU B 2 107 ? 138.550 144.866 96.643  1.00 18.40  ? 107 GLU A C   1 
ATOM   3151 O O   . GLU B 2 107 ? 137.820 143.876 96.757  1.00 18.40  ? 107 GLU A O   1 
ATOM   3152 C CB  . GLU B 2 107 ? 137.188 146.969 96.656  1.00 18.40  ? 107 GLU A CB  1 
ATOM   3153 C CG  . GLU B 2 107 ? 137.893 147.712 97.779  1.00 18.40  ? 107 GLU A CG  1 
ATOM   3154 C CD  . GLU B 2 107 ? 137.007 148.753 98.435  1.00 18.40  ? 107 GLU A CD  1 
ATOM   3155 O OE1 . GLU B 2 107 ? 135.802 148.800 98.109  1.00 18.40  ? 107 GLU A OE1 1 
ATOM   3156 O OE2 . GLU B 2 107 ? 137.515 149.525 99.276  1.00 18.40  ? 107 GLU A OE2 1 
ATOM   3157 N N   . VAL B 2 108 ? 139.749 144.956 97.213  1.00 17.31  ? 108 VAL A N   1 
ATOM   3158 C CA  . VAL B 2 108 ? 140.347 143.876 97.987  1.00 17.31  ? 108 VAL A CA  1 
ATOM   3159 C C   . VAL B 2 108 ? 140.352 144.278 99.454  1.00 17.31  ? 108 VAL A C   1 
ATOM   3160 O O   . VAL B 2 108 ? 140.840 145.358 99.808  1.00 17.31  ? 108 VAL A O   1 
ATOM   3161 C CB  . VAL B 2 108 ? 141.769 143.554 97.498  1.00 17.31  ? 108 VAL A CB  1 
ATOM   3162 C CG1 . VAL B 2 108 ? 142.418 142.516 98.399  1.00 17.31  ? 108 VAL A CG1 1 
ATOM   3163 C CG2 . VAL B 2 108 ? 141.733 143.068 96.060  1.00 17.31  ? 108 VAL A CG2 1 
ATOM   3164 N N   . PHE B 2 109 ? 139.810 143.412 100.302 1.00 17.92  ? 109 PHE A N   1 
ATOM   3165 C CA  . PHE B 2 109 ? 139.771 143.637 101.737 1.00 17.92  ? 109 PHE A CA  1 
ATOM   3166 C C   . PHE B 2 109 ? 140.617 142.595 102.455 1.00 17.92  ? 109 PHE A C   1 
ATOM   3167 O O   . PHE B 2 109 ? 140.883 141.508 101.935 1.00 17.92  ? 109 PHE A O   1 
ATOM   3168 C CB  . PHE B 2 109 ? 138.333 143.594 102.262 1.00 17.92  ? 109 PHE A CB  1 
ATOM   3169 C CG  . PHE B 2 109 ? 137.512 144.791 101.883 1.00 17.92  ? 109 PHE A CG  1 
ATOM   3170 C CD1 . PHE B 2 109 ? 138.102 146.036 101.744 1.00 17.92  ? 109 PHE A CD1 1 
ATOM   3171 C CD2 . PHE B 2 109 ? 136.150 144.672 101.665 1.00 17.92  ? 109 PHE A CD2 1 
ATOM   3172 C CE1 . PHE B 2 109 ? 137.348 147.140 101.397 1.00 17.92  ? 109 PHE A CE1 1 
ATOM   3173 C CE2 . PHE B 2 109 ? 135.391 145.772 101.316 1.00 17.92  ? 109 PHE A CE2 1 
ATOM   3174 C CZ  . PHE B 2 109 ? 135.991 147.008 101.182 1.00 17.92  ? 109 PHE A CZ  1 
ATOM   3175 N N   . SER B 2 110 ? 141.037 142.944 103.672 1.00 16.52  ? 110 SER A N   1 
ATOM   3176 C CA  . SER B 2 110 ? 141.851 142.058 104.510 1.00 16.52  ? 110 SER A CA  1 
ATOM   3177 C C   . SER B 2 110 ? 141.342 142.165 105.949 1.00 16.52  ? 110 SER A C   1 
ATOM   3178 O O   . SER B 2 110 ? 141.776 143.036 106.709 1.00 16.52  ? 110 SER A O   1 
ATOM   3179 C CB  . SER B 2 110 ? 143.330 142.410 104.399 1.00 16.52  ? 110 SER A CB  1 
ATOM   3180 O OG  . SER B 2 110 ? 144.125 141.575 105.222 1.00 16.52  ? 110 SER A OG  1 
ATOM   3181 N N   . ASP B 2 111 ? 140.425 141.270 106.313 1.00 16.59  ? 111 ASP A N   1 
ATOM   3182 C CA  . ASP B 2 111 ? 139.870 141.199 107.659 1.00 16.59  ? 111 ASP A CA  1 
ATOM   3183 C C   . ASP B 2 111 ? 139.339 139.787 107.882 1.00 16.59  ? 111 ASP A C   1 
ATOM   3184 O O   . ASP B 2 111 ? 139.352 138.948 106.978 1.00 16.59  ? 111 ASP A O   1 
ATOM   3185 C CB  . ASP B 2 111 ? 138.776 142.250 107.873 1.00 16.59  ? 111 ASP A CB  1 
ATOM   3186 C CG  . ASP B 2 111 ? 137.698 142.192 106.811 1.00 16.59  ? 111 ASP A CG  1 
ATOM   3187 O OD1 . ASP B 2 111 ? 137.880 141.451 105.826 1.00 16.59  ? 111 ASP A OD1 1 
ATOM   3188 O OD2 . ASP B 2 111 ? 136.671 142.888 106.958 1.00 16.59  ? 111 ASP A OD2 1 
ATOM   3189 N N   . TRP B 2 112 ? 138.869 139.531 109.106 1.00 15.31  ? 112 TRP A N   1 
ATOM   3190 C CA  . TRP B 2 112 ? 138.407 138.188 109.450 1.00 15.31  ? 112 TRP A CA  1 
ATOM   3191 C C   . TRP B 2 112 ? 137.169 137.792 108.652 1.00 15.31  ? 112 TRP A C   1 
ATOM   3192 O O   . TRP B 2 112 ? 137.088 136.667 108.146 1.00 15.31  ? 112 TRP A O   1 
ATOM   3193 C CB  . TRP B 2 112 ? 138.134 138.092 110.951 1.00 15.31  ? 112 TRP A CB  1 
ATOM   3194 C CG  . TRP B 2 112 ? 139.349 137.770 111.759 1.00 15.31  ? 112 TRP A CG  1 
ATOM   3195 C CD1 . TRP B 2 112 ? 140.154 138.649 112.427 1.00 15.31  ? 112 TRP A CD1 1 
ATOM   3196 C CD2 . TRP B 2 112 ? 139.901 136.467 111.987 1.00 15.31  ? 112 TRP A CD2 1 
ATOM   3197 N NE1 . TRP B 2 112 ? 141.172 137.975 113.056 1.00 15.31  ? 112 TRP A NE1 1 
ATOM   3198 C CE2 . TRP B 2 112 ? 141.044 136.635 112.801 1.00 15.31  ? 112 TRP A CE2 1 
ATOM   3199 C CE3 . TRP B 2 112 ? 139.544 135.179 111.581 1.00 15.31  ? 112 TRP A CE3 1 
ATOM   3200 C CZ2 . TRP B 2 112 ? 141.828 135.565 113.218 1.00 15.31  ? 112 TRP A CZ2 1 
ATOM   3201 C CZ3 . TRP B 2 112 ? 140.324 134.116 111.997 1.00 15.31  ? 112 TRP A CZ3 1 
ATOM   3202 C CH2 . TRP B 2 112 ? 141.455 134.316 112.807 1.00 15.31  ? 112 TRP A CH2 1 
ATOM   3203 N N   . LEU B 2 113 ? 136.199 138.695 108.524 1.00 14.87  ? 113 LEU A N   1 
ATOM   3204 C CA  . LEU B 2 113 ? 134.971 138.410 107.791 1.00 14.87  ? 113 LEU A CA  1 
ATOM   3205 C C   . LEU B 2 113 ? 134.670 139.576 106.864 1.00 14.87  ? 113 LEU A C   1 
ATOM   3206 O O   . LEU B 2 113 ? 134.649 140.730 107.302 1.00 14.87  ? 113 LEU A O   1 
ATOM   3207 C CB  . LEU B 2 113 ? 133.795 138.167 108.747 1.00 14.87  ? 113 LEU A CB  1 
ATOM   3208 C CG  . LEU B 2 113 ? 133.898 136.990 109.724 1.00 14.87  ? 113 LEU A CG  1 
ATOM   3209 C CD1 . LEU B 2 113 ? 132.695 136.971 110.649 1.00 14.87  ? 113 LEU A CD1 1 
ATOM   3210 C CD2 . LEU B 2 113 ? 134.024 135.663 108.989 1.00 14.87  ? 113 LEU A CD2 1 
ATOM   3211 N N   . LEU B 2 114 ? 134.444 139.274 105.588 1.00 13.48  ? 114 LEU A N   1 
ATOM   3212 C CA  . LEU B 2 114 ? 134.216 140.284 104.556 1.00 13.48  ? 114 LEU A CA  1 
ATOM   3213 C C   . LEU B 2 114 ? 133.015 139.902 103.704 1.00 13.48  ? 114 LEU A C   1 
ATOM   3214 O O   . LEU B 2 114 ? 133.092 139.820 102.477 1.00 13.48  ? 114 LEU A O   1 
ATOM   3215 C CB  . LEU B 2 114 ? 135.466 140.508 103.702 1.00 13.48  ? 114 LEU A CB  1 
ATOM   3216 C CG  . LEU B 2 114 ? 136.236 139.327 103.110 1.00 13.48  ? 114 LEU A CG  1 
ATOM   3217 C CD1 . LEU B 2 114 ? 136.063 139.277 101.602 1.00 13.48  ? 114 LEU A CD1 1 
ATOM   3218 C CD2 . LEU B 2 114 ? 137.709 139.427 103.468 1.00 13.48  ? 114 LEU A CD2 1 
ATOM   3219 N N   . LEU B 2 115 ? 131.893 139.630 104.377 1.00 13.54  ? 115 LEU A N   1 
ATOM   3220 C CA  . LEU B 2 115 ? 130.661 139.147 103.758 1.00 13.54  ? 115 LEU A CA  1 
ATOM   3221 C C   . LEU B 2 115 ? 130.413 139.774 102.393 1.00 13.54  ? 115 LEU A C   1 
ATOM   3222 O O   . LEU B 2 115 ? 130.411 140.999 102.243 1.00 13.54  ? 115 LEU A O   1 
ATOM   3223 C CB  . LEU B 2 115 ? 129.478 139.438 104.686 1.00 13.54  ? 115 LEU A CB  1 
ATOM   3224 C CG  . LEU B 2 115 ? 128.062 139.224 104.145 1.00 13.54  ? 115 LEU A CG  1 
ATOM   3225 C CD1 . LEU B 2 115 ? 127.210 138.503 105.174 1.00 13.54  ? 115 LEU A CD1 1 
ATOM   3226 C CD2 . LEU B 2 115 ? 127.416 140.550 103.764 1.00 13.54  ? 115 LEU A CD2 1 
ATOM   3227 N N   . GLN B 2 116 ? 130.188 138.917 101.405 1.00 14.17  ? 116 GLN A N   1 
ATOM   3228 C CA  . GLN B 2 116 ? 130.114 139.306 100.008 1.00 14.17  ? 116 GLN A CA  1 
ATOM   3229 C C   . GLN B 2 116 ? 128.689 139.187 99.486  1.00 14.17  ? 116 GLN A C   1 
ATOM   3230 O O   . GLN B 2 116 ? 127.888 138.379 99.972  1.00 14.17  ? 116 GLN A O   1 
ATOM   3231 C CB  . GLN B 2 116 ? 131.048 138.444 99.152  1.00 14.17  ? 116 GLN A CB  1 
ATOM   3232 C CG  . GLN B 2 116 ? 132.512 138.527 99.551  1.00 14.17  ? 116 GLN A CG  1 
ATOM   3233 C CD  . GLN B 2 116 ? 133.391 137.562 98.777  1.00 14.17  ? 116 GLN A CD  1 
ATOM   3234 O OE1 . GLN B 2 116 ? 132.897 136.684 98.068  1.00 14.17  ? 116 GLN A OE1 1 
ATOM   3235 N NE2 . GLN B 2 116 ? 134.702 137.721 98.909  1.00 14.17  ? 116 GLN A NE2 1 
ATOM   3236 N N   . ALA B 2 117 ? 128.392 140.007 98.480  1.00 14.65  ? 117 ALA A N   1 
ATOM   3237 C CA  . ALA B 2 117 ? 127.111 140.016 97.795  1.00 14.65  ? 117 ALA A CA  1 
ATOM   3238 C C   . ALA B 2 117 ? 127.341 139.865 96.298  1.00 14.65  ? 117 ALA A C   1 
ATOM   3239 O O   . ALA B 2 117 ? 128.451 140.061 95.797  1.00 14.65  ? 117 ALA A O   1 
ATOM   3240 C CB  . ALA B 2 117 ? 126.330 141.305 98.074  1.00 14.65  ? 117 ALA A CB  1 
ATOM   3241 N N   . SER B 2 118 ? 126.270 139.507 95.585  1.00 19.99  ? 118 SER A N   1 
ATOM   3242 C CA  . SER B 2 118 ? 126.367 139.368 94.135  1.00 19.99  ? 118 SER A CA  1 
ATOM   3243 C C   . SER B 2 118 ? 126.716 140.697 93.476  1.00 19.99  ? 118 SER A C   1 
ATOM   3244 O O   . SER B 2 118 ? 127.555 140.747 92.569  1.00 19.99  ? 118 SER A O   1 
ATOM   3245 C CB  . SER B 2 118 ? 125.058 138.815 93.570  1.00 19.99  ? 118 SER A CB  1 
ATOM   3246 O OG  . SER B 2 118 ? 125.138 138.651 92.164  1.00 19.99  ? 118 SER A OG  1 
ATOM   3247 N N   . ALA B 2 119 ? 126.087 141.782 93.921  1.00 24.99  ? 119 ALA A N   1 
ATOM   3248 C CA  . ALA B 2 119 ? 126.368 143.105 93.382  1.00 24.99  ? 119 ALA A CA  1 
ATOM   3249 C C   . ALA B 2 119 ? 125.962 144.152 94.407  1.00 24.99  ? 119 ALA A C   1 
ATOM   3250 O O   . ALA B 2 119 ? 125.059 143.927 95.217  1.00 24.99  ? 119 ALA A O   1 
ATOM   3251 C CB  . ALA B 2 119 ? 125.635 143.341 92.056  1.00 24.99  ? 119 ALA A CB  1 
ATOM   3252 N N   . GLU B 2 120 ? 126.649 145.297 94.366  1.00 26.08  ? 120 GLU A N   1 
ATOM   3253 C CA  . GLU B 2 120 ? 126.301 146.398 95.259  1.00 26.08  ? 120 GLU A CA  1 
ATOM   3254 C C   . GLU B 2 120 ? 124.899 146.921 94.969  1.00 26.08  ? 120 GLU A C   1 
ATOM   3255 O O   . GLU B 2 120 ? 124.127 147.197 95.894  1.00 26.08  ? 120 GLU A O   1 
ATOM   3256 C CB  . GLU B 2 120 ? 127.329 147.524 95.137  1.00 26.08  ? 120 GLU A CB  1 
ATOM   3257 C CG  . GLU B 2 120 ? 128.672 147.233 95.794  1.00 26.08  ? 120 GLU A CG  1 
ATOM   3258 C CD  . GLU B 2 120 ? 129.527 146.267 94.996  1.00 26.08  ? 120 GLU A CD  1 
ATOM   3259 O OE1 . GLU B 2 120 ? 129.167 145.963 93.838  1.00 26.08  ? 120 GLU A OE1 1 
ATOM   3260 O OE2 . GLU B 2 120 ? 130.562 145.813 95.526  1.00 26.08  ? 120 GLU A OE2 1 
ATOM   3261 N N   . VAL B 2 121 ? 124.554 147.063 93.692  1.00 29.69  ? 121 VAL A N   1 
ATOM   3262 C CA  . VAL B 2 121 ? 123.233 147.515 93.270  1.00 29.69  ? 121 VAL A CA  1 
ATOM   3263 C C   . VAL B 2 121 ? 122.553 146.361 92.544  1.00 29.69  ? 121 VAL A C   1 
ATOM   3264 O O   . VAL B 2 121 ? 123.107 145.803 91.588  1.00 29.69  ? 121 VAL A O   1 
ATOM   3265 C CB  . VAL B 2 121 ? 123.316 148.766 92.381  1.00 29.69  ? 121 VAL A CB  1 
ATOM   3266 C CG1 . VAL B 2 121 ? 123.530 150.005 93.236  1.00 29.69  ? 121 VAL A CG1 1 
ATOM   3267 C CG2 . VAL B 2 121 ? 124.440 148.628 91.363  1.00 29.69  ? 121 VAL A CG2 1 
ATOM   3268 N N   . VAL B 2 122 ? 121.360 145.997 93.006  1.00 34.68  ? 122 VAL A N   1 
ATOM   3269 C CA  . VAL B 2 122 ? 120.590 144.896 92.439  1.00 34.68  ? 122 VAL A CA  1 
ATOM   3270 C C   . VAL B 2 122 ? 119.218 145.422 92.048  1.00 34.68  ? 122 VAL A C   1 
ATOM   3271 O O   . VAL B 2 122 ? 118.538 146.062 92.859  1.00 34.68  ? 122 VAL A O   1 
ATOM   3272 C CB  . VAL B 2 122 ? 120.463 143.722 93.428  1.00 34.68  ? 122 VAL A CB  1 
ATOM   3273 C CG1 . VAL B 2 122 ? 119.630 142.603 92.822  1.00 34.68  ? 122 VAL A CG1 1 
ATOM   3274 C CG2 . VAL B 2 122 ? 121.839 143.211 93.828  1.00 34.68  ? 122 VAL A CG2 1 
ATOM   3275 N N   . MET B 2 123 ? 118.816 145.157 90.808  1.00 48.71  ? 123 MET A N   1 
ATOM   3276 C CA  . MET B 2 123 ? 117.497 145.559 90.345  1.00 48.71  ? 123 MET A CA  1 
ATOM   3277 C C   . MET B 2 123 ? 116.416 144.773 91.079  1.00 48.71  ? 123 MET A C   1 
ATOM   3278 O O   . MET B 2 123 ? 116.613 143.621 91.475  1.00 48.71  ? 123 MET A O   1 
ATOM   3279 C CB  . MET B 2 123 ? 117.375 145.345 88.835  1.00 48.71  ? 123 MET A CB  1 
ATOM   3280 C CG  . MET B 2 123 ? 116.142 145.976 88.207  1.00 48.71  ? 123 MET A CG  1 
ATOM   3281 S SD  . MET B 2 123 ? 116.086 147.763 88.439  1.00 48.71  ? 123 MET A SD  1 
ATOM   3282 C CE  . MET B 2 123 ? 114.555 148.165 87.601  1.00 48.71  ? 123 MET A CE  1 
ATOM   3283 N N   . GLU B 2 124 ? 115.266 145.418 91.272  1.00 51.80  ? 124 GLU A N   1 
ATOM   3284 C CA  . GLU B 2 124 ? 114.158 144.781 91.973  1.00 51.80  ? 124 GLU A CA  1 
ATOM   3285 C C   . GLU B 2 124 ? 113.692 143.538 91.226  1.00 51.80  ? 124 GLU A C   1 
ATOM   3286 O O   . GLU B 2 124 ? 113.519 143.557 90.003  1.00 51.80  ? 124 GLU A O   1 
ATOM   3287 C CB  . GLU B 2 124 ? 113.003 145.770 92.142  1.00 51.80  ? 124 GLU A CB  1 
ATOM   3288 C CG  . GLU B 2 124 ? 112.573 146.461 90.858  1.00 51.80  ? 124 GLU A CG  1 
ATOM   3289 C CD  . GLU B 2 124 ? 111.434 147.437 91.075  1.00 51.80  ? 124 GLU A CD  1 
ATOM   3290 O OE1 . GLU B 2 124 ? 110.962 147.556 92.226  1.00 51.80  ? 124 GLU A OE1 1 
ATOM   3291 O OE2 . GLU B 2 124 ? 111.010 148.086 90.096  1.00 51.80  ? 124 GLU A OE2 1 
ATOM   3292 N N   . GLY B 2 125 ? 113.498 142.449 91.969  1.00 43.86  ? 125 GLY A N   1 
ATOM   3293 C CA  . GLY B 2 125 ? 113.099 141.182 91.404  1.00 43.86  ? 125 GLY A CA  1 
ATOM   3294 C C   . GLY B 2 125 ? 114.239 140.245 91.066  1.00 43.86  ? 125 GLY A C   1 
ATOM   3295 O O   . GLY B 2 125 ? 114.009 139.040 90.917  1.00 43.86  ? 125 GLY A O   1 
ATOM   3296 N N   . GLN B 2 126 ? 115.461 140.762 90.940  1.00 39.65  ? 126 GLN A N   1 
ATOM   3297 C CA  . GLN B 2 126 ? 116.613 139.922 90.662  1.00 39.65  ? 126 GLN A CA  1 
ATOM   3298 C C   . GLN B 2 126 ? 117.060 139.190 91.926  1.00 39.65  ? 126 GLN A C   1 
ATOM   3299 O O   . GLN B 2 126 ? 116.930 139.716 93.035  1.00 39.65  ? 126 GLN A O   1 
ATOM   3300 C CB  . GLN B 2 126 ? 117.764 140.761 90.116  1.00 39.65  ? 126 GLN A CB  1 
ATOM   3301 C CG  . GLN B 2 126 ? 117.455 141.466 88.804  1.00 39.65  ? 126 GLN A CG  1 
ATOM   3302 C CD  . GLN B 2 126 ? 117.273 140.502 87.647  1.00 39.65  ? 126 GLN A CD  1 
ATOM   3303 O OE1 . GLN B 2 126 ? 117.751 139.368 87.686  1.00 39.65  ? 126 GLN A OE1 1 
ATOM   3304 N NE2 . GLN B 2 126 ? 116.576 140.950 86.609  1.00 39.65  ? 126 GLN A NE2 1 
ATOM   3305 N N   . PRO B 2 127 ? 117.581 137.972 91.786  1.00 30.24  ? 127 PRO A N   1 
ATOM   3306 C CA  . PRO B 2 127 ? 118.065 137.242 92.964  1.00 30.24  ? 127 PRO A CA  1 
ATOM   3307 C C   . PRO B 2 127 ? 119.255 137.943 93.602  1.00 30.24  ? 127 PRO A C   1 
ATOM   3308 O O   . PRO B 2 127 ? 120.089 138.542 92.919  1.00 30.24  ? 127 PRO A O   1 
ATOM   3309 C CB  . PRO B 2 127 ? 118.452 135.871 92.398  1.00 30.24  ? 127 PRO A CB  1 
ATOM   3310 C CG  . PRO B 2 127 ? 118.724 136.124 90.952  1.00 30.24  ? 127 PRO A CG  1 
ATOM   3311 C CD  . PRO B 2 127 ? 117.759 137.199 90.545  1.00 30.24  ? 127 PRO A CD  1 
ATOM   3312 N N   . LEU B 2 128 ? 119.327 137.863 94.929  1.00 23.40  ? 128 LEU A N   1 
ATOM   3313 C CA  . LEU B 2 128 ? 120.411 138.457 95.699  1.00 23.40  ? 128 LEU A CA  1 
ATOM   3314 C C   . LEU B 2 128 ? 121.011 137.396 96.607  1.00 23.40  ? 128 LEU A C   1 
ATOM   3315 O O   . LEU B 2 128 ? 120.285 136.731 97.352  1.00 23.40  ? 128 LEU A O   1 
ATOM   3316 C CB  . LEU B 2 128 ? 119.916 139.648 96.526  1.00 23.40  ? 128 LEU A CB  1 
ATOM   3317 C CG  . LEU B 2 128 ? 120.937 140.296 97.464  1.00 23.40  ? 128 LEU A CG  1 
ATOM   3318 C CD1 . LEU B 2 128 ? 122.134 140.816 96.683  1.00 23.40  ? 128 LEU A CD1 1 
ATOM   3319 C CD2 . LEU B 2 128 ? 120.292 141.412 98.271  1.00 23.40  ? 128 LEU A CD2 1 
ATOM   3320 N N   . PHE B 2 129 ? 122.331 137.242 96.546  1.00 17.76  ? 129 PHE A N   1 
ATOM   3321 C CA  . PHE B 2 129 ? 123.050 136.263 97.352  1.00 17.76  ? 129 PHE A CA  1 
ATOM   3322 C C   . PHE B 2 129 ? 123.994 136.991 98.298  1.00 17.76  ? 129 PHE A C   1 
ATOM   3323 O O   . PHE B 2 129 ? 124.843 137.771 97.854  1.00 17.76  ? 129 PHE A O   1 
ATOM   3324 C CB  . PHE B 2 129 ? 123.825 135.283 96.468  1.00 17.76  ? 129 PHE A CB  1 
ATOM   3325 C CG  . PHE B 2 129 ? 122.964 134.230 95.832  1.00 17.76  ? 129 PHE A CG  1 
ATOM   3326 C CD1 . PHE B 2 129 ? 122.328 134.469 94.625  1.00 17.76  ? 129 PHE A CD1 1 
ATOM   3327 C CD2 . PHE B 2 129 ? 122.791 132.998 96.443  1.00 17.76  ? 129 PHE A CD2 1 
ATOM   3328 C CE1 . PHE B 2 129 ? 121.535 133.500 94.039  1.00 17.76  ? 129 PHE A CE1 1 
ATOM   3329 C CE2 . PHE B 2 129 ? 121.999 132.025 95.863  1.00 17.76  ? 129 PHE A CE2 1 
ATOM   3330 C CZ  . PHE B 2 129 ? 121.371 132.276 94.659  1.00 17.76  ? 129 PHE A CZ  1 
ATOM   3331 N N   . LEU B 2 130 ? 123.842 136.733 99.593  1.00 15.91  ? 130 LEU A N   1 
ATOM   3332 C CA  . LEU B 2 130 ? 124.714 137.276 100.627 1.00 15.91  ? 130 LEU A CA  1 
ATOM   3333 C C   . LEU B 2 130 ? 125.368 136.119 101.366 1.00 15.91  ? 130 LEU A C   1 
ATOM   3334 O O   . LEU B 2 130 ? 124.678 135.183 101.783 1.00 15.91  ? 130 LEU A O   1 
ATOM   3335 C CB  . LEU B 2 130 ? 123.930 138.150 101.611 1.00 15.91  ? 130 LEU A CB  1 
ATOM   3336 C CG  . LEU B 2 130 ? 123.248 139.410 101.078 1.00 15.91  ? 130 LEU A CG  1 
ATOM   3337 C CD1 . LEU B 2 130 ? 122.147 139.854 102.027 1.00 15.91  ? 130 LEU A CD1 1 
ATOM   3338 C CD2 . LEU B 2 130 ? 124.263 140.521 100.895 1.00 15.91  ? 130 LEU A CD2 1 
ATOM   3339 N N   . ARG B 2 131 ? 126.688 136.175 101.530 1.00 12.18  ? 131 ARG A N   1 
ATOM   3340 C CA  . ARG B 2 131 ? 127.365 135.109 102.260 1.00 12.18  ? 131 ARG A CA  1 
ATOM   3341 C C   . ARG B 2 131 ? 128.517 135.671 103.077 1.00 12.18  ? 131 ARG A C   1 
ATOM   3342 O O   . ARG B 2 131 ? 129.333 136.439 102.562 1.00 12.18  ? 131 ARG A O   1 
ATOM   3343 C CB  . ARG B 2 131 ? 127.868 134.015 101.310 1.00 12.18  ? 131 ARG A CB  1 
ATOM   3344 C CG  . ARG B 2 131 ? 128.743 134.500 100.171 1.00 12.18  ? 131 ARG A CG  1 
ATOM   3345 C CD  . ARG B 2 131 ? 129.236 133.325 99.348  1.00 12.18  ? 131 ARG A CD  1 
ATOM   3346 N NE  . ARG B 2 131 ? 130.102 132.440 100.118 1.00 12.18  ? 131 ARG A NE  1 
ATOM   3347 C CZ  . ARG B 2 131 ? 131.427 132.468 100.074 1.00 12.18  ? 131 ARG A CZ  1 
ATOM   3348 N NH1 . ARG B 2 131 ? 132.075 133.318 99.296  1.00 12.18  ? 131 ARG A NH1 1 
ATOM   3349 N NH2 . ARG B 2 131 ? 132.118 131.618 100.829 1.00 12.18  ? 131 ARG A NH2 1 
ATOM   3350 N N   . CYS B 2 132 ? 128.583 135.269 104.344 1.00 12.43  ? 132 CYS A N   1 
ATOM   3351 C CA  . CYS B 2 132 ? 129.640 135.701 105.252 1.00 12.43  ? 132 CYS A CA  1 
ATOM   3352 C C   . CYS B 2 132 ? 130.884 134.864 104.980 1.00 12.43  ? 132 CYS A C   1 
ATOM   3353 O O   . CYS B 2 132 ? 130.894 133.655 105.235 1.00 12.43  ? 132 CYS A O   1 
ATOM   3354 C CB  . CYS B 2 132 ? 129.174 135.556 106.697 1.00 12.43  ? 132 CYS A CB  1 
ATOM   3355 S SG  . CYS B 2 132 ? 130.185 136.381 107.947 1.00 12.43  ? 132 CYS A SG  1 
ATOM   3356 N N   . HIS B 2 133 ? 131.933 135.499 104.465 1.00 13.62  ? 133 HIS A N   1 
ATOM   3357 C CA  . HIS B 2 133 ? 133.136 134.801 104.031 1.00 13.62  ? 133 HIS A CA  1 
ATOM   3358 C C   . HIS B 2 133 ? 134.307 135.167 104.933 1.00 13.62  ? 133 HIS A C   1 
ATOM   3359 O O   . HIS B 2 133 ? 134.570 136.353 105.174 1.00 13.62  ? 133 HIS A O   1 
ATOM   3360 C CB  . HIS B 2 133 ? 133.463 135.130 102.573 1.00 13.62  ? 133 HIS A CB  1 
ATOM   3361 C CG  . HIS B 2 133 ? 134.375 134.138 101.919 1.00 13.62  ? 133 HIS A CG  1 
ATOM   3362 N ND1 . HIS B 2 133 ? 134.622 134.137 100.563 1.00 13.62  ? 133 HIS A ND1 1 
ATOM   3363 C CD2 . HIS B 2 133 ? 135.095 133.113 102.433 1.00 13.62  ? 133 HIS A CD2 1 
ATOM   3364 C CE1 . HIS B 2 133 ? 135.457 133.156 100.270 1.00 13.62  ? 133 HIS A CE1 1 
ATOM   3365 N NE2 . HIS B 2 133 ? 135.759 132.520 101.388 1.00 13.62  ? 133 HIS A NE2 1 
ATOM   3366 N N   . GLY B 2 134 ? 135.010 134.141 105.420 1.00 11.82  ? 134 GLY A N   1 
ATOM   3367 C CA  . GLY B 2 134 ? 136.159 134.323 106.276 1.00 11.82  ? 134 GLY A CA  1 
ATOM   3368 C C   . GLY B 2 134 ? 137.478 134.124 105.540 1.00 11.82  ? 134 GLY A C   1 
ATOM   3369 O O   . GLY B 2 134 ? 137.526 133.689 104.393 1.00 11.82  ? 134 GLY A O   1 
ATOM   3370 N N   . TRP B 2 135 ? 138.561 134.439 106.247 1.00 16.56  ? 135 TRP A N   1 
ATOM   3371 C CA  . TRP B 2 135 ? 139.890 134.444 105.649 1.00 16.56  ? 135 TRP A CA  1 
ATOM   3372 C C   . TRP B 2 135 ? 140.307 133.040 105.222 1.00 16.56  ? 135 TRP A C   1 
ATOM   3373 O O   . TRP B 2 135 ? 140.135 132.074 105.972 1.00 16.56  ? 135 TRP A O   1 
ATOM   3374 C CB  . TRP B 2 135 ? 140.900 135.024 106.639 1.00 16.56  ? 135 TRP A CB  1 
ATOM   3375 C CG  . TRP B 2 135 ? 142.306 135.070 106.129 1.00 16.56  ? 135 TRP A CG  1 
ATOM   3376 C CD1 . TRP B 2 135 ? 143.341 134.266 106.507 1.00 16.56  ? 135 TRP A CD1 1 
ATOM   3377 C CD2 . TRP B 2 135 ? 142.836 135.970 105.148 1.00 16.56  ? 135 TRP A CD2 1 
ATOM   3378 N NE1 . TRP B 2 135 ? 144.482 134.609 105.824 1.00 16.56  ? 135 TRP A NE1 1 
ATOM   3379 C CE2 . TRP B 2 135 ? 144.198 135.652 104.982 1.00 16.56  ? 135 TRP A CE2 1 
ATOM   3380 C CE3 . TRP B 2 135 ? 142.290 137.013 104.393 1.00 16.56  ? 135 TRP A CE3 1 
ATOM   3381 C CZ2 . TRP B 2 135 ? 145.023 136.339 104.093 1.00 16.56  ? 135 TRP A CZ2 1 
ATOM   3382 C CZ3 . TRP B 2 135 ? 143.110 137.694 103.511 1.00 16.56  ? 135 TRP A CZ3 1 
ATOM   3383 C CH2 . TRP B 2 135 ? 144.461 137.354 103.368 1.00 16.56  ? 135 TRP A CH2 1 
ATOM   3384 N N   . ARG B 2 136 ? 140.859 132.938 104.010 1.00 14.97  ? 136 ARG A N   1 
ATOM   3385 C CA  . ARG B 2 136 ? 141.335 131.672 103.443 1.00 14.97  ? 136 ARG A CA  1 
ATOM   3386 C C   . ARG B 2 136 ? 140.237 130.611 103.424 1.00 14.97  ? 136 ARG A C   1 
ATOM   3387 O O   . ARG B 2 136 ? 140.494 129.423 103.630 1.00 14.97  ? 136 ARG A O   1 
ATOM   3388 C CB  . ARG B 2 136 ? 142.572 131.161 104.187 1.00 14.97  ? 136 ARG A CB  1 
ATOM   3389 C CG  . ARG B 2 136 ? 143.823 131.987 103.942 1.00 14.97  ? 136 ARG A CG  1 
ATOM   3390 C CD  . ARG B 2 136 ? 145.028 131.397 104.656 1.00 14.97  ? 136 ARG A CD  1 
ATOM   3391 N NE  . ARG B 2 136 ? 146.221 132.218 104.480 1.00 14.97  ? 136 ARG A NE  1 
ATOM   3392 C CZ  . ARG B 2 136 ? 147.067 132.102 103.466 1.00 14.97  ? 136 ARG A CZ  1 
ATOM   3393 N NH1 . ARG B 2 136 ? 146.884 131.205 102.511 1.00 14.97  ? 136 ARG A NH1 1 
ATOM   3394 N NH2 . ARG B 2 136 ? 148.125 132.907 103.408 1.00 14.97  ? 136 ARG A NH2 1 
ATOM   3395 N N   . ASN B 2 137 ? 139.002 131.048 103.167 1.00 15.79  ? 137 ASN A N   1 
ATOM   3396 C CA  . ASN B 2 137 ? 137.848 130.154 103.037 1.00 15.79  ? 137 ASN A CA  1 
ATOM   3397 C C   . ASN B 2 137 ? 137.671 129.286 104.283 1.00 15.79  ? 137 ASN A C   1 
ATOM   3398 O O   . ASN B 2 137 ? 137.279 128.120 104.200 1.00 15.79  ? 137 ASN A O   1 
ATOM   3399 C CB  . ASN B 2 137 ? 137.961 129.288 101.780 1.00 15.79  ? 137 ASN A CB  1 
ATOM   3400 C CG  . ASN B 2 137 ? 136.612 128.819 101.268 1.00 15.79  ? 137 ASN A CG  1 
ATOM   3401 O OD1 . ASN B 2 137 ? 135.634 128.767 102.014 1.00 15.79  ? 137 ASN A OD1 1 
ATOM   3402 N ND2 . ASN B 2 137 ? 136.554 128.472 99.988  1.00 15.79  ? 137 ASN A ND2 1 
ATOM   3403 N N   . TRP B 2 138 ? 137.969 129.856 105.447 1.00 17.02  ? 138 TRP A N   1 
ATOM   3404 C CA  . TRP B 2 138 ? 137.794 129.131 106.697 1.00 17.02  ? 138 TRP A CA  1 
ATOM   3405 C C   . TRP B 2 138 ? 136.314 129.011 107.041 1.00 17.02  ? 138 TRP A C   1 
ATOM   3406 O O   . TRP B 2 138 ? 135.522 129.919 106.776 1.00 17.02  ? 138 TRP A O   1 
ATOM   3407 C CB  . TRP B 2 138 ? 138.545 129.830 107.829 1.00 17.02  ? 138 TRP A CB  1 
ATOM   3408 C CG  . TRP B 2 138 ? 140.030 129.634 107.773 1.00 17.02  ? 138 TRP A CG  1 
ATOM   3409 C CD1 . TRP B 2 138 ? 140.706 128.703 107.039 1.00 17.02  ? 138 TRP A CD1 1 
ATOM   3410 C CD2 . TRP B 2 138 ? 141.024 130.391 108.474 1.00 17.02  ? 138 TRP A CD2 1 
ATOM   3411 N NE1 . TRP B 2 138 ? 142.059 128.831 107.243 1.00 17.02  ? 138 TRP A NE1 1 
ATOM   3412 C CE2 . TRP B 2 138 ? 142.280 129.860 108.119 1.00 17.02  ? 138 TRP A CE2 1 
ATOM   3413 C CE3 . TRP B 2 138 ? 140.974 131.465 109.368 1.00 17.02  ? 138 TRP A CE3 1 
ATOM   3414 C CZ2 . TRP B 2 138 ? 143.475 130.366 108.627 1.00 17.02  ? 138 TRP A CZ2 1 
ATOM   3415 C CZ3 . TRP B 2 138 ? 142.162 131.966 109.871 1.00 17.02  ? 138 TRP A CZ3 1 
ATOM   3416 C CH2 . TRP B 2 138 ? 143.395 131.417 109.499 1.00 17.02  ? 138 TRP A CH2 1 
ATOM   3417 N N   . ASP B 2 139 ? 135.945 127.876 107.629 1.00 18.74  ? 139 ASP A N   1 
ATOM   3418 C CA  . ASP B 2 139 ? 134.559 127.650 108.014 1.00 18.74  ? 139 ASP A CA  1 
ATOM   3419 C C   . ASP B 2 139 ? 134.151 128.621 109.115 1.00 18.74  ? 139 ASP A C   1 
ATOM   3420 O O   . ASP B 2 139 ? 134.924 128.907 110.033 1.00 18.74  ? 139 ASP A O   1 
ATOM   3421 C CB  . ASP B 2 139 ? 134.367 126.207 108.481 1.00 18.74  ? 139 ASP A CB  1 
ATOM   3422 C CG  . ASP B 2 139 ? 132.918 125.759 108.419 1.00 18.74  ? 139 ASP A CG  1 
ATOM   3423 O OD1 . ASP B 2 139 ? 132.017 126.622 108.483 1.00 18.74  ? 139 ASP A OD1 1 
ATOM   3424 O OD2 . ASP B 2 139 ? 132.680 124.538 108.306 1.00 18.74  ? 139 ASP A OD2 1 
ATOM   3425 N N   . VAL B 2 140 ? 132.925 129.130 109.017 1.00 18.13  ? 140 VAL A N   1 
ATOM   3426 C CA  . VAL B 2 140 ? 132.395 130.111 109.956 1.00 18.13  ? 140 VAL A CA  1 
ATOM   3427 C C   . VAL B 2 140 ? 131.171 129.513 110.635 1.00 18.13  ? 140 VAL A C   1 
ATOM   3428 O O   . VAL B 2 140 ? 130.252 129.034 109.961 1.00 18.13  ? 140 VAL A O   1 
ATOM   3429 C CB  . VAL B 2 140 ? 132.039 131.435 109.256 1.00 18.13  ? 140 VAL A CB  1 
ATOM   3430 C CG1 . VAL B 2 140 ? 131.646 132.488 110.280 1.00 18.13  ? 140 VAL A CG1 1 
ATOM   3431 C CG2 . VAL B 2 140 ? 133.204 131.918 108.405 1.00 18.13  ? 140 VAL A CG2 1 
ATOM   3432 N N   . TYR B 2 141 ? 131.162 129.543 111.965 1.00 17.77  ? 141 TYR A N   1 
ATOM   3433 C CA  . TYR B 2 141 ? 130.057 129.035 112.761 1.00 17.77  ? 141 TYR A CA  1 
ATOM   3434 C C   . TYR B 2 141 ? 129.415 130.176 113.540 1.00 17.77  ? 141 TYR A C   1 
ATOM   3435 O O   . TYR B 2 141 ? 129.990 131.259 113.682 1.00 17.77  ? 141 TYR A O   1 
ATOM   3436 C CB  . TYR B 2 141 ? 130.522 127.937 113.728 1.00 17.77  ? 141 TYR A CB  1 
ATOM   3437 C CG  . TYR B 2 141 ? 130.999 126.675 113.044 1.00 17.77  ? 141 TYR A CG  1 
ATOM   3438 C CD1 . TYR B 2 141 ? 130.525 126.319 111.789 1.00 17.77  ? 141 TYR A CD1 1 
ATOM   3439 C CD2 . TYR B 2 141 ? 131.925 125.840 113.656 1.00 17.77  ? 141 TYR A CD2 1 
ATOM   3440 C CE1 . TYR B 2 141 ? 130.958 125.166 111.161 1.00 17.77  ? 141 TYR A CE1 1 
ATOM   3441 C CE2 . TYR B 2 141 ? 132.364 124.685 113.036 1.00 17.77  ? 141 TYR A CE2 1 
ATOM   3442 C CZ  . TYR B 2 141 ? 131.878 124.354 111.789 1.00 17.77  ? 141 TYR A CZ  1 
ATOM   3443 O OH  . TYR B 2 141 ? 132.313 123.205 111.169 1.00 17.77  ? 141 TYR A OH  1 
ATOM   3444 N N   . LYS B 2 142 ? 128.208 129.911 114.048 1.00 16.52  ? 142 LYS A N   1 
ATOM   3445 C CA  . LYS B 2 142 ? 127.432 130.897 114.804 1.00 16.52  ? 142 LYS A CA  1 
ATOM   3446 C C   . LYS B 2 142 ? 127.239 132.183 114.002 1.00 16.52  ? 142 LYS A C   1 
ATOM   3447 O O   . LYS B 2 142 ? 127.373 133.291 114.526 1.00 16.52  ? 142 LYS A O   1 
ATOM   3448 C CB  . LYS B 2 142 ? 128.081 131.194 116.159 1.00 16.52  ? 142 LYS A CB  1 
ATOM   3449 C CG  . LYS B 2 142 ? 128.185 129.989 117.078 1.00 16.52  ? 142 LYS A CG  1 
ATOM   3450 C CD  . LYS B 2 142 ? 126.812 129.448 117.439 1.00 16.52  ? 142 LYS A CD  1 
ATOM   3451 C CE  . LYS B 2 142 ? 126.916 128.275 118.400 1.00 16.52  ? 142 LYS A CE  1 
ATOM   3452 N NZ  . LYS B 2 142 ? 127.598 128.657 119.668 1.00 16.52  ? 142 LYS A NZ  1 
ATOM   3453 N N   . VAL B 2 143 ? 126.921 132.033 112.720 1.00 16.05  ? 143 VAL A N   1 
ATOM   3454 C CA  . VAL B 2 143 ? 126.768 133.176 111.827 1.00 16.05  ? 143 VAL A CA  1 
ATOM   3455 C C   . VAL B 2 143 ? 125.441 133.862 112.127 1.00 16.05  ? 143 VAL A C   1 
ATOM   3456 O O   . VAL B 2 143 ? 124.373 133.252 112.005 1.00 16.05  ? 143 VAL A O   1 
ATOM   3457 C CB  . VAL B 2 143 ? 126.844 132.743 110.356 1.00 16.05  ? 143 VAL A CB  1 
ATOM   3458 C CG1 . VAL B 2 143 ? 126.911 133.961 109.448 1.00 16.05  ? 143 VAL A CG1 1 
ATOM   3459 C CG2 . VAL B 2 143 ? 128.040 131.831 110.132 1.00 16.05  ? 143 VAL A CG2 1 
ATOM   3460 N N   . ILE B 2 144 ? 125.507 135.132 112.517 1.00 17.73  ? 144 ILE A N   1 
ATOM   3461 C CA  . ILE B 2 144 ? 124.325 135.945 112.779 1.00 17.73  ? 144 ILE A CA  1 
ATOM   3462 C C   . ILE B 2 144 ? 124.376 137.147 111.849 1.00 17.73  ? 144 ILE A C   1 
ATOM   3463 O O   . ILE B 2 144 ? 125.363 137.894 111.847 1.00 17.73  ? 144 ILE A O   1 
ATOM   3464 C CB  . ILE B 2 144 ? 124.248 136.393 114.247 1.00 17.73  ? 144 ILE A CB  1 
ATOM   3465 C CG1 . ILE B 2 144 ? 124.574 135.228 115.182 1.00 17.73  ? 144 ILE A CG1 1 
ATOM   3466 C CG2 . ILE B 2 144 ? 122.868 136.950 114.558 1.00 17.73  ? 144 ILE A CG2 1 
ATOM   3467 C CD1 . ILE B 2 144 ? 124.537 135.594 116.650 1.00 17.73  ? 144 ILE A CD1 1 
ATOM   3468 N N   . TYR B 2 145 ? 123.318 137.339 111.068 1.00 18.83  ? 145 TYR A N   1 
ATOM   3469 C CA  . TYR B 2 145 ? 123.233 138.444 110.123 1.00 18.83  ? 145 TYR A CA  1 
ATOM   3470 C C   . TYR B 2 145 ? 122.409 139.571 110.731 1.00 18.83  ? 145 TYR A C   1 
ATOM   3471 O O   . TYR B 2 145 ? 121.309 139.335 111.242 1.00 18.83  ? 145 TYR A O   1 
ATOM   3472 C CB  . TYR B 2 145 ? 122.609 137.989 108.803 1.00 18.83  ? 145 TYR A CB  1 
ATOM   3473 C CG  . TYR B 2 145 ? 123.340 136.847 108.134 1.00 18.83  ? 145 TYR A CG  1 
ATOM   3474 C CD1 . TYR B 2 145 ? 124.434 137.084 107.312 1.00 18.83  ? 145 TYR A CD1 1 
ATOM   3475 C CD2 . TYR B 2 145 ? 122.931 135.533 108.316 1.00 18.83  ? 145 TYR A CD2 1 
ATOM   3476 C CE1 . TYR B 2 145 ? 125.103 136.044 106.695 1.00 18.83  ? 145 TYR A CE1 1 
ATOM   3477 C CE2 . TYR B 2 145 ? 123.594 134.486 107.703 1.00 18.83  ? 145 TYR A CE2 1 
ATOM   3478 C CZ  . TYR B 2 145 ? 124.679 134.748 106.893 1.00 18.83  ? 145 TYR A CZ  1 
ATOM   3479 O OH  . TYR B 2 145 ? 125.342 133.709 106.281 1.00 18.83  ? 145 TYR A OH  1 
ATOM   3480 N N   . TYR B 2 146 ? 122.941 140.790 110.676 1.00 25.42  ? 146 TYR A N   1 
ATOM   3481 C CA  . TYR B 2 146 ? 122.270 141.972 111.195 1.00 25.42  ? 146 TYR A CA  1 
ATOM   3482 C C   . TYR B 2 146 ? 122.057 142.959 110.059 1.00 25.42  ? 146 TYR A C   1 
ATOM   3483 O O   . TYR B 2 146 ? 122.995 143.266 109.311 1.00 25.42  ? 146 TYR A O   1 
ATOM   3484 C CB  . TYR B 2 146 ? 123.083 142.627 112.314 1.00 25.42  ? 146 TYR A CB  1 
ATOM   3485 C CG  . TYR B 2 146 ? 123.398 141.718 113.481 1.00 25.42  ? 146 TYR A CG  1 
ATOM   3486 C CD1 . TYR B 2 146 ? 124.532 140.917 113.476 1.00 25.42  ? 146 TYR A CD1 1 
ATOM   3487 C CD2 . TYR B 2 146 ? 122.568 141.671 114.593 1.00 25.42  ? 146 TYR A CD2 1 
ATOM   3488 C CE1 . TYR B 2 146 ? 124.826 140.087 114.542 1.00 25.42  ? 146 TYR A CE1 1 
ATOM   3489 C CE2 . TYR B 2 146 ? 122.853 140.845 115.663 1.00 25.42  ? 146 TYR A CE2 1 
ATOM   3490 C CZ  . TYR B 2 146 ? 123.983 140.056 115.633 1.00 25.42  ? 146 TYR A CZ  1 
ATOM   3491 O OH  . TYR B 2 146 ? 124.272 139.232 116.696 1.00 25.42  ? 146 TYR A OH  1 
ATOM   3492 N N   . LYS B 2 147 ? 120.827 143.451 109.936 1.00 24.19  ? 147 LYS A N   1 
ATOM   3493 C CA  . LYS B 2 147 ? 120.459 144.459 108.950 1.00 24.19  ? 147 LYS A CA  1 
ATOM   3494 C C   . LYS B 2 147 ? 120.130 145.753 109.682 1.00 24.19  ? 147 LYS A C   1 
ATOM   3495 O O   . LYS B 2 147 ? 119.279 145.759 110.578 1.00 24.19  ? 147 LYS A O   1 
ATOM   3496 C CB  . LYS B 2 147 ? 119.270 143.997 108.109 1.00 24.19  ? 147 LYS A CB  1 
ATOM   3497 C CG  . LYS B 2 147 ? 118.866 144.973 107.017 1.00 24.19  ? 147 LYS A CG  1 
ATOM   3498 C CD  . LYS B 2 147 ? 117.590 144.529 106.321 1.00 24.19  ? 147 LYS A CD  1 
ATOM   3499 C CE  . LYS B 2 147 ? 116.416 144.496 107.286 1.00 24.19  ? 147 LYS A CE  1 
ATOM   3500 N NZ  . LYS B 2 147 ? 116.128 145.841 107.856 1.00 24.19  ? 147 LYS A NZ  1 
ATOM   3501 N N   . ASP B 2 148 ? 120.811 146.838 109.299 1.00 20.77  ? 148 ASP A N   1 
ATOM   3502 C CA  . ASP B 2 148 ? 120.674 148.170 109.891 1.00 20.77  ? 148 ASP A CA  1 
ATOM   3503 C C   . ASP B 2 148 ? 120.572 148.127 111.413 1.00 20.77  ? 148 ASP A C   1 
ATOM   3504 O O   . ASP B 2 148 ? 119.816 148.897 112.014 1.00 20.77  ? 148 ASP A O   1 
ATOM   3505 C CB  . ASP B 2 148 ? 119.475 148.921 109.289 1.00 20.77  ? 148 ASP A CB  1 
ATOM   3506 C CG  . ASP B 2 148 ? 118.157 148.186 109.462 1.00 20.77  ? 148 ASP A CG  1 
ATOM   3507 O OD1 . ASP B 2 148 ? 117.598 148.199 110.579 1.00 20.77  ? 148 ASP A OD1 1 
ATOM   3508 O OD2 . ASP B 2 148 ? 117.675 147.596 108.473 1.00 20.77  ? 148 ASP A OD2 1 
ATOM   3509 N N   . GLY B 2 149 ? 121.344 147.245 112.046 1.00 20.24  ? 149 GLY A N   1 
ATOM   3510 C CA  . GLY B 2 149 ? 121.330 147.105 113.485 1.00 20.24  ? 149 GLY A CA  1 
ATOM   3511 C C   . GLY B 2 149 ? 120.345 146.094 114.030 1.00 20.24  ? 149 GLY A C   1 
ATOM   3512 O O   . GLY B 2 149 ? 120.337 145.857 115.245 1.00 20.24  ? 149 GLY A O   1 
ATOM   3513 N N   . GLU B 2 150 ? 119.519 145.492 113.180 1.00 19.94  ? 150 GLU A N   1 
ATOM   3514 C CA  . GLU B 2 150 ? 118.540 144.497 113.597 1.00 19.94  ? 150 GLU A CA  1 
ATOM   3515 C C   . GLU B 2 150 ? 118.925 143.139 113.026 1.00 19.94  ? 150 GLU A C   1 
ATOM   3516 O O   . GLU B 2 150 ? 119.210 143.022 111.830 1.00 19.94  ? 150 GLU A O   1 
ATOM   3517 C CB  . GLU B 2 150 ? 117.132 144.885 113.140 1.00 19.94  ? 150 GLU A CB  1 
ATOM   3518 C CG  . GLU B 2 150 ? 116.595 146.155 113.782 1.00 19.94  ? 150 GLU A CG  1 
ATOM   3519 C CD  . GLU B 2 150 ? 116.298 145.985 115.261 1.00 19.94  ? 150 GLU A CD  1 
ATOM   3520 O OE1 . GLU B 2 150 ? 116.121 144.832 115.707 1.00 19.94  ? 150 GLU A OE1 1 
ATOM   3521 O OE2 . GLU B 2 150 ? 116.241 147.006 115.977 1.00 19.94  ? 150 GLU A OE2 1 
ATOM   3522 N N   . ALA B 2 151 ? 118.934 142.121 113.884 1.00 16.89  ? 151 ALA A N   1 
ATOM   3523 C CA  . ALA B 2 151 ? 119.299 140.779 113.453 1.00 16.89  ? 151 ALA A CA  1 
ATOM   3524 C C   . ALA B 2 151 ? 118.275 140.232 112.467 1.00 16.89  ? 151 ALA A C   1 
ATOM   3525 O O   . ALA B 2 151 ? 117.072 140.474 112.594 1.00 16.89  ? 151 ALA A O   1 
ATOM   3526 C CB  . ALA B 2 151 ? 119.416 139.847 114.659 1.00 16.89  ? 151 ALA A CB  1 
ATOM   3527 N N   . LEU B 2 152 ? 118.763 139.487 111.476 1.00 15.92  ? 152 LEU A N   1 
ATOM   3528 C CA  . LEU B 2 152 ? 117.918 138.894 110.448 1.00 15.92  ? 152 LEU A CA  1 
ATOM   3529 C C   . LEU B 2 152 ? 117.835 137.379 110.555 1.00 15.92  ? 152 LEU A C   1 
ATOM   3530 O O   . LEU B 2 152 ? 116.735 136.825 110.645 1.00 15.92  ? 152 LEU A O   1 
ATOM   3531 C CB  . LEU B 2 152 ? 118.429 139.291 109.055 1.00 15.92  ? 152 LEU A CB  1 
ATOM   3532 C CG  . LEU B 2 152 ? 117.624 138.775 107.861 1.00 15.92  ? 152 LEU A CG  1 
ATOM   3533 C CD1 . LEU B 2 152 ? 116.196 139.295 107.911 1.00 15.92  ? 152 LEU A CD1 1 
ATOM   3534 C CD2 . LEU B 2 152 ? 118.295 139.164 106.553 1.00 15.92  ? 152 LEU A CD2 1 
ATOM   3535 N N   . LYS B 2 153 ? 118.975 136.690 110.550 1.00 17.58  ? 153 LYS A N   1 
ATOM   3536 C CA  . LYS B 2 153 ? 119.002 135.238 110.633 1.00 17.58  ? 153 LYS A CA  1 
ATOM   3537 C C   . LYS B 2 153 ? 120.154 134.798 111.525 1.00 17.58  ? 153 LYS A C   1 
ATOM   3538 O O   . LYS B 2 153 ? 121.147 135.511 111.695 1.00 17.58  ? 153 LYS A O   1 
ATOM   3539 C CB  . LYS B 2 153 ? 119.133 134.589 109.247 1.00 17.58  ? 153 LYS A CB  1 
ATOM   3540 C CG  . LYS B 2 153 ? 117.901 134.729 108.366 1.00 17.58  ? 153 LYS A CG  1 
ATOM   3541 C CD  . LYS B 2 153 ? 116.697 134.031 108.980 1.00 17.58  ? 153 LYS A CD  1 
ATOM   3542 C CE  . LYS B 2 153 ? 116.945 132.541 109.148 1.00 17.58  ? 153 LYS A CE  1 
ATOM   3543 N NZ  . LYS B 2 153 ? 115.778 131.849 109.762 1.00 17.58  ? 153 LYS A NZ  1 
ATOM   3544 N N   . TYR B 2 154 ? 120.003 133.607 112.101 1.00 17.41  ? 154 TYR A N   1 
ATOM   3545 C CA  . TYR B 2 154 ? 121.024 132.990 112.937 1.00 17.41  ? 154 TYR A CA  1 
ATOM   3546 C C   . TYR B 2 154 ? 121.196 131.540 112.513 1.00 17.41  ? 154 TYR A C   1 
ATOM   3547 O O   . TYR B 2 154 ? 120.206 130.829 112.312 1.00 17.41  ? 154 TYR A O   1 
ATOM   3548 C CB  . TYR B 2 154 ? 120.651 133.070 114.422 1.00 17.41  ? 154 TYR A CB  1 
ATOM   3549 C CG  . TYR B 2 154 ? 121.395 132.085 115.297 1.00 17.41  ? 154 TYR A CG  1 
ATOM   3550 C CD1 . TYR B 2 154 ? 122.716 132.308 115.661 1.00 17.41  ? 154 TYR A CD1 1 
ATOM   3551 C CD2 . TYR B 2 154 ? 120.773 130.933 115.764 1.00 17.41  ? 154 TYR A CD2 1 
ATOM   3552 C CE1 . TYR B 2 154 ? 123.399 131.412 116.461 1.00 17.41  ? 154 TYR A CE1 1 
ATOM   3553 C CE2 . TYR B 2 154 ? 121.448 130.031 116.565 1.00 17.41  ? 154 TYR A CE2 1 
ATOM   3554 C CZ  . TYR B 2 154 ? 122.760 130.275 116.910 1.00 17.41  ? 154 TYR A CZ  1 
ATOM   3555 O OH  . TYR B 2 154 ? 123.436 129.381 117.707 1.00 17.41  ? 154 TYR A OH  1 
ATOM   3556 N N   . TRP B 2 155 ? 122.447 131.105 112.379 1.00 20.19  ? 155 TRP A N   1 
ATOM   3557 C CA  . TRP B 2 155 ? 122.742 129.735 111.989 1.00 20.19  ? 155 TRP A CA  1 
ATOM   3558 C C   . TRP B 2 155 ? 123.979 129.250 112.730 1.00 20.19  ? 155 TRP A C   1 
ATOM   3559 O O   . TRP B 2 155 ? 124.856 130.034 113.101 1.00 20.19  ? 155 TRP A O   1 
ATOM   3560 C CB  . TRP B 2 155 ? 122.963 129.609 110.475 1.00 20.19  ? 155 TRP A CB  1 
ATOM   3561 C CG  . TRP B 2 155 ? 121.816 130.096 109.642 1.00 20.19  ? 155 TRP A CG  1 
ATOM   3562 C CD1 . TRP B 2 155 ? 121.603 131.372 109.208 1.00 20.19  ? 155 TRP A CD1 1 
ATOM   3563 C CD2 . TRP B 2 155 ? 120.729 129.312 109.135 1.00 20.19  ? 155 TRP A CD2 1 
ATOM   3564 N NE1 . TRP B 2 155 ? 120.448 131.433 108.466 1.00 20.19  ? 155 TRP A NE1 1 
ATOM   3565 C CE2 . TRP B 2 155 ? 119.893 130.181 108.406 1.00 20.19  ? 155 TRP A CE2 1 
ATOM   3566 C CE3 . TRP B 2 155 ? 120.381 127.962 109.229 1.00 20.19  ? 155 TRP A CE3 1 
ATOM   3567 C CZ2 . TRP B 2 155 ? 118.731 129.743 107.775 1.00 20.19  ? 155 TRP A CZ2 1 
ATOM   3568 C CZ3 . TRP B 2 155 ? 119.227 127.529 108.601 1.00 20.19  ? 155 TRP A CZ3 1 
ATOM   3569 C CH2 . TRP B 2 155 ? 118.416 128.417 107.883 1.00 20.19  ? 155 TRP A CH2 1 
ATOM   3570 N N   . TYR B 2 156 ? 124.039 127.933 112.943 1.00 20.07  ? 156 TYR A N   1 
ATOM   3571 C CA  . TYR B 2 156 ? 125.242 127.288 113.447 1.00 20.07  ? 156 TYR A CA  1 
ATOM   3572 C C   . TYR B 2 156 ? 126.205 126.883 112.342 1.00 20.07  ? 156 TYR A C   1 
ATOM   3573 O O   . TYR B 2 156 ? 127.419 126.896 112.567 1.00 20.07  ? 156 TYR A O   1 
ATOM   3574 C CB  . TYR B 2 156 ? 124.881 126.046 114.276 1.00 20.07  ? 156 TYR A CB  1 
ATOM   3575 C CG  . TYR B 2 156 ? 126.080 125.270 114.776 1.00 20.07  ? 156 TYR A CG  1 
ATOM   3576 C CD1 . TYR B 2 156 ? 126.802 125.704 115.880 1.00 20.07  ? 156 TYR A CD1 1 
ATOM   3577 C CD2 . TYR B 2 156 ? 126.489 124.101 114.145 1.00 20.07  ? 156 TYR A CD2 1 
ATOM   3578 C CE1 . TYR B 2 156 ? 127.898 124.999 116.341 1.00 20.07  ? 156 TYR A CE1 1 
ATOM   3579 C CE2 . TYR B 2 156 ? 127.584 123.389 114.599 1.00 20.07  ? 156 TYR A CE2 1 
ATOM   3580 C CZ  . TYR B 2 156 ? 128.284 123.842 115.697 1.00 20.07  ? 156 TYR A CZ  1 
ATOM   3581 O OH  . TYR B 2 156 ? 129.374 123.137 116.152 1.00 20.07  ? 156 TYR A OH  1 
ATOM   3582 N N   . GLU B 2 157 ? 125.695 126.532 111.165 1.00 21.17  ? 157 GLU A N   1 
ATOM   3583 C CA  . GLU B 2 157 ? 126.505 126.239 109.993 1.00 21.17  ? 157 GLU A CA  1 
ATOM   3584 C C   . GLU B 2 157 ? 126.326 127.377 109.001 1.00 21.17  ? 157 GLU A C   1 
ATOM   3585 O O   . GLU B 2 157 ? 125.213 127.888 108.836 1.00 21.17  ? 157 GLU A O   1 
ATOM   3586 C CB  . GLU B 2 157 ? 126.100 124.905 109.359 1.00 21.17  ? 157 GLU A CB  1 
ATOM   3587 C CG  . GLU B 2 157 ? 127.170 124.275 108.483 1.00 21.17  ? 157 GLU A CG  1 
ATOM   3588 C CD  . GLU B 2 157 ? 128.168 123.460 109.282 1.00 21.17  ? 157 GLU A CD  1 
ATOM   3589 O OE1 . GLU B 2 157 ? 127.815 123.010 110.393 1.00 21.17  ? 157 GLU A OE1 1 
ATOM   3590 O OE2 . GLU B 2 157 ? 129.305 123.268 108.801 1.00 21.17  ? 157 GLU A OE2 1 
ATOM   3591 N N   . ASN B 2 158 ? 127.419 127.783 108.355 1.00 17.21  ? 158 ASN A N   1 
ATOM   3592 C CA  . ASN B 2 158 ? 127.370 128.900 107.419 1.00 17.21  ? 158 ASN A CA  1 
ATOM   3593 C C   . ASN B 2 158 ? 126.424 128.598 106.263 1.00 17.21  ? 158 ASN A C   1 
ATOM   3594 O O   . ASN B 2 158 ? 126.442 127.494 105.710 1.00 17.21  ? 158 ASN A O   1 
ATOM   3595 C CB  . ASN B 2 158 ? 128.771 129.222 106.894 1.00 17.21  ? 158 ASN A CB  1 
ATOM   3596 C CG  . ASN B 2 158 ? 128.806 130.493 106.068 1.00 17.21  ? 158 ASN A CG  1 
ATOM   3597 O OD1 . ASN B 2 158 ? 127.923 131.343 106.178 1.00 17.21  ? 158 ASN A OD1 1 
ATOM   3598 N ND2 . ASN B 2 158 ? 129.831 130.629 105.235 1.00 17.21  ? 158 ASN A ND2 1 
ATOM   3599 N N   . HIS B 2 159 ? 125.598 129.571 105.894 1.00 18.02  ? 159 HIS A N   1 
ATOM   3600 C CA  . HIS B 2 159 ? 124.612 129.399 104.834 1.00 18.02  ? 159 HIS A CA  1 
ATOM   3601 C C   . HIS B 2 159 ? 124.614 130.655 103.969 1.00 18.02  ? 159 HIS A C   1 
ATOM   3602 O O   . HIS B 2 159 ? 125.453 131.547 104.139 1.00 18.02  ? 159 HIS A O   1 
ATOM   3603 C CB  . HIS B 2 159 ? 123.223 129.108 105.414 1.00 18.02  ? 159 HIS A CB  1 
ATOM   3604 C CG  . HIS B 2 159 ? 123.061 127.712 105.929 1.00 18.02  ? 159 HIS A CG  1 
ATOM   3605 N ND1 . HIS B 2 159 ? 123.635 127.278 107.104 1.00 18.02  ? 159 HIS A ND1 1 
ATOM   3606 C CD2 . HIS B 2 159 ? 122.385 126.651 105.428 1.00 18.02  ? 159 HIS A CD2 1 
ATOM   3607 C CE1 . HIS B 2 159 ? 123.321 126.011 107.305 1.00 18.02  ? 159 HIS A CE1 1 
ATOM   3608 N NE2 . HIS B 2 159 ? 122.563 125.606 106.302 1.00 18.02  ? 159 HIS A NE2 1 
ATOM   3609 N N   . ASN B 2 160 ? 123.667 130.725 103.037 1.00 16.08  ? 160 ASN A N   1 
ATOM   3610 C CA  . ASN B 2 160 ? 123.531 131.850 102.125 1.00 16.08  ? 160 ASN A CA  1 
ATOM   3611 C C   . ASN B 2 160 ? 122.177 132.517 102.318 1.00 16.08  ? 160 ASN A C   1 
ATOM   3612 O O   . ASN B 2 160 ? 121.150 131.839 102.420 1.00 16.08  ? 160 ASN A O   1 
ATOM   3613 C CB  . ASN B 2 160 ? 123.669 131.406 100.663 1.00 16.08  ? 160 ASN A CB  1 
ATOM   3614 C CG  . ASN B 2 160 ? 125.093 131.051 100.286 1.00 16.08  ? 160 ASN A CG  1 
ATOM   3615 O OD1 . ASN B 2 160 ? 126.040 131.356 101.011 1.00 16.08  ? 160 ASN A OD1 1 
ATOM   3616 N ND2 . ASN B 2 160 ? 125.249 130.405 99.135  1.00 16.08  ? 160 ASN A ND2 1 
ATOM   3617 N N   . ILE B 2 161 ? 122.182 133.845 102.369 1.00 17.72  ? 161 ILE A N   1 
ATOM   3618 C CA  . ILE B 2 161 ? 120.955 134.629 102.315 1.00 17.72  ? 161 ILE A CA  1 
ATOM   3619 C C   . ILE B 2 161 ? 120.590 134.784 100.844 1.00 17.72  ? 161 ILE A C   1 
ATOM   3620 O O   . ILE B 2 161 ? 121.248 135.525 100.109 1.00 17.72  ? 161 ILE A O   1 
ATOM   3621 C CB  . ILE B 2 161 ? 121.119 135.993 102.996 1.00 17.72  ? 161 ILE A CB  1 
ATOM   3622 C CG1 . ILE B 2 161 ? 121.401 135.818 104.489 1.00 17.72  ? 161 ILE A CG1 1 
ATOM   3623 C CG2 . ILE B 2 161 ? 119.876 136.847 102.785 1.00 17.72  ? 161 ILE A CG2 1 
ATOM   3624 C CD1 . ILE B 2 161 ? 121.477 137.125 105.246 1.00 17.72  ? 161 ILE A CD1 1 
ATOM   3625 N N   . SER B 2 162 ? 119.555 134.072 100.411 1.00 25.98  ? 162 SER A N   1 
ATOM   3626 C CA  . SER B 2 162 ? 119.128 134.051 99.015  1.00 25.98  ? 162 SER A CA  1 
ATOM   3627 C C   . SER B 2 162 ? 117.752 134.700 98.923  1.00 25.98  ? 162 SER A C   1 
ATOM   3628 O O   . SER B 2 162 ? 116.743 134.095 99.297  1.00 25.98  ? 162 SER A O   1 
ATOM   3629 C CB  . SER B 2 162 ? 119.110 132.624 98.474  1.00 25.98  ? 162 SER A CB  1 
ATOM   3630 O OG  . SER B 2 162 ? 118.709 132.599 97.115  1.00 25.98  ? 162 SER A OG  1 
ATOM   3631 N N   . ILE B 2 163 ? 117.716 135.931 98.426  1.00 29.35  ? 163 ILE A N   1 
ATOM   3632 C CA  . ILE B 2 163 ? 116.474 136.668 98.222  1.00 29.35  ? 163 ILE A CA  1 
ATOM   3633 C C   . ILE B 2 163 ? 116.115 136.523 96.747  1.00 29.35  ? 163 ILE A C   1 
ATOM   3634 O O   . ILE B 2 163 ? 116.666 137.219 95.889  1.00 29.35  ? 163 ILE A O   1 
ATOM   3635 C CB  . ILE B 2 163 ? 116.608 138.135 98.636  1.00 29.35  ? 163 ILE A CB  1 
ATOM   3636 C CG1 . ILE B 2 163 ? 117.060 138.236 100.095 1.00 29.35  ? 163 ILE A CG1 1 
ATOM   3637 C CG2 . ILE B 2 163 ? 115.290 138.867 98.435  1.00 29.35  ? 163 ILE A CG2 1 
ATOM   3638 C CD1 . ILE B 2 163 ? 117.226 139.658 100.586 1.00 29.35  ? 163 ILE A CD1 1 
ATOM   3639 N N   . THR B 2 164 ? 115.192 135.606 96.450  1.00 32.50  ? 164 THR A N   1 
ATOM   3640 C CA  . THR B 2 164 ? 114.789 135.381 95.065  1.00 32.50  ? 164 THR A CA  1 
ATOM   3641 C C   . THR B 2 164 ? 114.103 136.609 94.481  1.00 32.50  ? 164 THR A C   1 
ATOM   3642 O O   . THR B 2 164 ? 114.343 136.973 93.324  1.00 32.50  ? 164 THR A O   1 
ATOM   3643 C CB  . THR B 2 164 ? 113.871 134.162 94.975  1.00 32.50  ? 164 THR A CB  1 
ATOM   3644 O OG1 . THR B 2 164 ? 112.705 134.379 95.780  1.00 32.50  ? 164 THR A OG1 1 
ATOM   3645 C CG2 . THR B 2 164 ? 114.592 132.914 95.464  1.00 32.50  ? 164 THR A CG2 1 
ATOM   3646 N N   . ASN B 2 165 ? 113.247 137.260 95.264  1.00 43.76  ? 165 ASN A N   1 
ATOM   3647 C CA  . ASN B 2 165 ? 112.526 138.457 94.837  1.00 43.76  ? 165 ASN A CA  1 
ATOM   3648 C C   . ASN B 2 165 ? 112.970 139.614 95.726  1.00 43.76  ? 165 ASN A C   1 
ATOM   3649 O O   . ASN B 2 165 ? 112.490 139.759 96.855  1.00 43.76  ? 165 ASN A O   1 
ATOM   3650 C CB  . ASN B 2 165 ? 111.016 138.243 94.908  1.00 43.76  ? 165 ASN A CB  1 
ATOM   3651 C CG  . ASN B 2 165 ? 110.233 139.441 94.410  1.00 43.76  ? 165 ASN A CG  1 
ATOM   3652 O OD1 . ASN B 2 165 ? 110.746 140.261 93.648  1.00 43.76  ? 165 ASN A OD1 1 
ATOM   3653 N ND2 . ASN B 2 165 ? 108.980 139.549 94.838  1.00 43.76  ? 165 ASN A ND2 1 
ATOM   3654 N N   . ALA B 2 166 ? 113.888 140.432 95.218  1.00 41.22  ? 166 ALA A N   1 
ATOM   3655 C CA  . ALA B 2 166 ? 114.382 141.570 95.979  1.00 41.22  ? 166 ALA A CA  1 
ATOM   3656 C C   . ALA B 2 166 ? 113.280 142.604 96.173  1.00 41.22  ? 166 ALA A C   1 
ATOM   3657 O O   . ALA B 2 166 ? 112.517 142.905 95.251  1.00 41.22  ? 166 ALA A O   1 
ATOM   3658 C CB  . ALA B 2 166 ? 115.580 142.204 95.273  1.00 41.22  ? 166 ALA A CB  1 
ATOM   3659 N N   . THR B 2 167 ? 113.200 143.146 97.383  1.00 40.15  ? 167 THR A N   1 
ATOM   3660 C CA  . THR B 2 167 ? 112.196 144.136 97.743  1.00 40.15  ? 167 THR A CA  1 
ATOM   3661 C C   . THR B 2 167 ? 112.874 145.433 98.167  1.00 40.15  ? 167 THR A C   1 
ATOM   3662 O O   . THR B 2 167 ? 114.084 145.485 98.403  1.00 40.15  ? 167 THR A O   1 
ATOM   3663 C CB  . THR B 2 167 ? 111.287 143.621 98.868  1.00 40.15  ? 167 THR A CB  1 
ATOM   3664 O OG1 . THR B 2 167 ? 112.078 143.310 100.021 1.00 40.15  ? 167 THR A OG1 1 
ATOM   3665 C CG2 . THR B 2 167 ? 110.539 142.374 98.420  1.00 40.15  ? 167 THR A CG2 1 
ATOM   3666 N N   . VAL B 2 168 ? 112.067 146.492 98.258  1.00 42.05  ? 168 VAL A N   1 
ATOM   3667 C CA  . VAL B 2 168 ? 112.587 147.794 98.662  1.00 42.05  ? 168 VAL A CA  1 
ATOM   3668 C C   . VAL B 2 168 ? 113.061 147.756 100.110 1.00 42.05  ? 168 VAL A C   1 
ATOM   3669 O O   . VAL B 2 168 ? 114.050 148.405 100.472 1.00 42.05  ? 168 VAL A O   1 
ATOM   3670 C CB  . VAL B 2 168 ? 111.522 148.884 98.441  1.00 42.05  ? 168 VAL A CB  1 
ATOM   3671 C CG1 . VAL B 2 168 ? 112.094 150.262 98.742  1.00 42.05  ? 168 VAL A CG1 1 
ATOM   3672 C CG2 . VAL B 2 168 ? 110.988 148.821 97.018  1.00 42.05  ? 168 VAL A CG2 1 
ATOM   3673 N N   . GLU B 2 169 ? 112.369 146.994 100.960 1.00 41.10  ? 169 GLU A N   1 
ATOM   3674 C CA  . GLU B 2 169 ? 112.735 146.911 102.370 1.00 41.10  ? 169 GLU A CA  1 
ATOM   3675 C C   . GLU B 2 169 ? 114.099 146.267 102.584 1.00 41.10  ? 169 GLU A C   1 
ATOM   3676 O O   . GLU B 2 169 ? 114.676 146.417 103.666 1.00 41.10  ? 169 GLU A O   1 
ATOM   3677 C CB  . GLU B 2 169 ? 111.670 146.136 103.150 1.00 41.10  ? 169 GLU A CB  1 
ATOM   3678 C CG  . GLU B 2 169 ? 110.307 146.814 103.214 1.00 41.10  ? 169 GLU A CG  1 
ATOM   3679 C CD  . GLU B 2 169 ? 109.498 146.642 101.942 1.00 41.10  ? 169 GLU A CD  1 
ATOM   3680 O OE1 . GLU B 2 169 ? 109.921 145.856 101.067 1.00 41.10  ? 169 GLU A OE1 1 
ATOM   3681 O OE2 . GLU B 2 169 ? 108.440 147.292 101.816 1.00 41.10  ? 169 GLU A OE2 1 
ATOM   3682 N N   . ASP B 2 170 ? 114.625 145.555 101.585 1.00 33.26  ? 170 ASP A N   1 
ATOM   3683 C CA  . ASP B 2 170 ? 115.936 144.931 101.709 1.00 33.26  ? 170 ASP A CA  1 
ATOM   3684 C C   . ASP B 2 170 ? 117.078 145.939 101.695 1.00 33.26  ? 170 ASP A C   1 
ATOM   3685 O O   . ASP B 2 170 ? 118.215 145.561 101.993 1.00 33.26  ? 170 ASP A O   1 
ATOM   3686 C CB  . ASP B 2 170 ? 116.139 143.909 100.588 1.00 33.26  ? 170 ASP A CB  1 
ATOM   3687 C CG  . ASP B 2 170 ? 115.128 142.781 100.638 1.00 33.26  ? 170 ASP A CG  1 
ATOM   3688 O OD1 . ASP B 2 170 ? 114.670 142.440 101.749 1.00 33.26  ? 170 ASP A OD1 1 
ATOM   3689 O OD2 . ASP B 2 170 ? 114.791 142.235 99.567  1.00 33.26  ? 170 ASP A OD2 1 
ATOM   3690 N N   . SER B 2 171 ? 116.809 147.197 101.354 1.00 31.66  ? 171 SER A N   1 
ATOM   3691 C CA  . SER B 2 171 ? 117.855 148.208 101.328 1.00 31.66  ? 171 SER A CA  1 
ATOM   3692 C C   . SER B 2 171 ? 118.349 148.513 102.738 1.00 31.66  ? 171 SER A C   1 
ATOM   3693 O O   . SER B 2 171 ? 117.591 148.476 103.711 1.00 31.66  ? 171 SER A O   1 
ATOM   3694 C CB  . SER B 2 171 ? 117.344 149.488 100.666 1.00 31.66  ? 171 SER A CB  1 
ATOM   3695 O OG  . SER B 2 171 ? 116.935 149.245 99.332  1.00 31.66  ? 171 SER A OG  1 
ATOM   3696 N N   . GLY B 2 172 ? 119.641 148.816 102.839 1.00 32.06  ? 172 GLY A N   1 
ATOM   3697 C CA  . GLY B 2 172 ? 120.247 149.125 104.117 1.00 32.06  ? 172 GLY A CA  1 
ATOM   3698 C C   . GLY B 2 172 ? 121.665 148.614 104.274 1.00 32.06  ? 172 GLY A C   1 
ATOM   3699 O O   . GLY B 2 172 ? 122.415 148.495 103.297 1.00 32.06  ? 172 GLY A O   1 
ATOM   3700 N N   . THR B 2 173 ? 122.043 148.320 105.515 1.00 28.19  ? 173 THR A N   1 
ATOM   3701 C CA  . THR B 2 173 ? 123.385 147.876 105.860 1.00 28.19  ? 173 THR A CA  1 
ATOM   3702 C C   . THR B 2 173 ? 123.320 146.469 106.435 1.00 28.19  ? 173 THR A C   1 
ATOM   3703 O O   . THR B 2 173 ? 122.572 146.218 107.385 1.00 28.19  ? 173 THR A O   1 
ATOM   3704 C CB  . THR B 2 173 ? 124.034 148.830 106.867 1.00 28.19  ? 173 THR A CB  1 
ATOM   3705 O OG1 . THR B 2 173 ? 124.350 150.071 106.222 1.00 28.19  ? 173 THR A OG1 1 
ATOM   3706 C CG2 . THR B 2 173 ? 125.299 148.222 107.445 1.00 28.19  ? 173 THR A CG2 1 
ATOM   3707 N N   . TYR B 2 174 ? 124.106 145.561 105.865 1.00 25.42  ? 174 TYR A N   1 
ATOM   3708 C CA  . TYR B 2 174 ? 124.187 144.182 106.321 1.00 25.42  ? 174 TYR A CA  1 
ATOM   3709 C C   . TYR B 2 174 ? 125.579 143.899 106.868 1.00 25.42  ? 174 TYR A C   1 
ATOM   3710 O O   . TYR B 2 174 ? 126.582 144.325 106.286 1.00 25.42  ? 174 TYR A O   1 
ATOM   3711 C CB  . TYR B 2 174 ? 123.875 143.202 105.185 1.00 25.42  ? 174 TYR A CB  1 
ATOM   3712 C CG  . TYR B 2 174 ? 122.427 143.180 104.752 1.00 25.42  ? 174 TYR A CG  1 
ATOM   3713 C CD1 . TYR B 2 174 ? 121.931 144.129 103.870 1.00 25.42  ? 174 TYR A CD1 1 
ATOM   3714 C CD2 . TYR B 2 174 ? 121.560 142.198 105.214 1.00 25.42  ? 174 TYR A CD2 1 
ATOM   3715 C CE1 . TYR B 2 174 ? 120.609 144.108 103.467 1.00 25.42  ? 174 TYR A CE1 1 
ATOM   3716 C CE2 . TYR B 2 174 ? 120.237 142.168 104.816 1.00 25.42  ? 174 TYR A CE2 1 
ATOM   3717 C CZ  . TYR B 2 174 ? 119.767 143.126 103.943 1.00 25.42  ? 174 TYR A CZ  1 
ATOM   3718 O OH  . TYR B 2 174 ? 118.451 143.101 103.544 1.00 25.42  ? 174 TYR A OH  1 
ATOM   3719 N N   . TYR B 2 175 ? 125.636 143.189 107.994 1.00 22.45  ? 175 TYR A N   1 
ATOM   3720 C CA  . TYR B 2 175 ? 126.915 142.742 108.528 1.00 22.45  ? 175 TYR A CA  1 
ATOM   3721 C C   . TYR B 2 175 ? 126.717 141.460 109.324 1.00 22.45  ? 175 TYR A C   1 
ATOM   3722 O O   . TYR B 2 175 ? 125.695 141.286 109.991 1.00 22.45  ? 175 TYR A O   1 
ATOM   3723 C CB  . TYR B 2 175 ? 127.579 143.822 109.396 1.00 22.45  ? 175 TYR A CB  1 
ATOM   3724 C CG  . TYR B 2 175 ? 126.752 144.306 110.566 1.00 22.45  ? 175 TYR A CG  1 
ATOM   3725 C CD1 . TYR B 2 175 ? 125.804 145.308 110.406 1.00 22.45  ? 175 TYR A CD1 1 
ATOM   3726 C CD2 . TYR B 2 175 ? 126.936 143.777 111.837 1.00 22.45  ? 175 TYR A CD2 1 
ATOM   3727 C CE1 . TYR B 2 175 ? 125.052 145.760 111.474 1.00 22.45  ? 175 TYR A CE1 1 
ATOM   3728 C CE2 . TYR B 2 175 ? 126.190 144.222 112.912 1.00 22.45  ? 175 TYR A CE2 1 
ATOM   3729 C CZ  . TYR B 2 175 ? 125.250 145.214 112.725 1.00 22.45  ? 175 TYR A CZ  1 
ATOM   3730 O OH  . TYR B 2 175 ? 124.504 145.660 113.791 1.00 22.45  ? 175 TYR A OH  1 
ATOM   3731 N N   . CYS B 2 176 ? 127.702 140.570 109.256 1.00 18.04  ? 176 CYS A N   1 
ATOM   3732 C CA  . CYS B 2 176 ? 127.625 139.269 109.902 1.00 18.04  ? 176 CYS A CA  1 
ATOM   3733 C C   . CYS B 2 176 ? 128.608 139.182 111.060 1.00 18.04  ? 176 CYS A C   1 
ATOM   3734 O O   . CYS B 2 176 ? 129.743 139.661 110.966 1.00 18.04  ? 176 CYS A O   1 
ATOM   3735 C CB  . CYS B 2 176 ? 127.904 138.135 108.910 1.00 18.04  ? 176 CYS A CB  1 
ATOM   3736 S SG  . CYS B 2 176 ? 129.460 138.278 108.001 1.00 18.04  ? 176 CYS A SG  1 
ATOM   3737 N N   . THR B 2 177 ? 128.160 138.568 112.150 1.00 17.22  ? 177 THR A N   1 
ATOM   3738 C CA  . THR B 2 177 ? 129.006 138.232 113.287 1.00 17.22  ? 177 THR A CA  1 
ATOM   3739 C C   . THR B 2 177 ? 129.158 136.718 113.320 1.00 17.22  ? 177 THR A C   1 
ATOM   3740 O O   . THR B 2 177 ? 128.157 135.992 113.343 1.00 17.22  ? 177 THR A O   1 
ATOM   3741 C CB  . THR B 2 177 ? 128.408 138.748 114.596 1.00 17.22  ? 177 THR A CB  1 
ATOM   3742 O OG1 . THR B 2 177 ? 128.225 140.167 114.514 1.00 17.22  ? 177 THR A OG1 1 
ATOM   3743 C CG2 . THR B 2 177 ? 129.328 138.429 115.763 1.00 17.22  ? 177 THR A CG2 1 
ATOM   3744 N N   . GLY B 2 178 ? 130.396 136.246 113.319 1.00 14.69  ? 178 GLY A N   1 
ATOM   3745 C CA  . GLY B 2 178 ? 130.656 134.824 113.195 1.00 14.69  ? 178 GLY A CA  1 
ATOM   3746 C C   . GLY B 2 178 ? 131.727 134.364 114.159 1.00 14.69  ? 178 GLY A C   1 
ATOM   3747 O O   . GLY B 2 178 ? 132.648 135.107 114.502 1.00 14.69  ? 178 GLY A O   1 
ATOM   3748 N N   . LYS B 2 179 ? 131.595 133.113 114.591 1.00 16.97  ? 179 LYS A N   1 
ATOM   3749 C CA  . LYS B 2 179 ? 132.559 132.481 115.484 1.00 16.97  ? 179 LYS A CA  1 
ATOM   3750 C C   . LYS B 2 179 ? 133.489 131.610 114.647 1.00 16.97  ? 179 LYS A C   1 
ATOM   3751 O O   . LYS B 2 179 ? 133.113 130.510 114.227 1.00 16.97  ? 179 LYS A O   1 
ATOM   3752 C CB  . LYS B 2 179 ? 131.852 131.662 116.561 1.00 16.97  ? 179 LYS A CB  1 
ATOM   3753 C CG  . LYS B 2 179 ? 132.795 130.988 117.544 1.00 16.97  ? 179 LYS A CG  1 
ATOM   3754 C CD  . LYS B 2 179 ? 132.033 130.362 118.700 1.00 16.97  ? 179 LYS A CD  1 
ATOM   3755 C CE  . LYS B 2 179 ? 131.274 131.415 119.491 1.00 16.97  ? 179 LYS A CE  1 
ATOM   3756 N NZ  . LYS B 2 179 ? 130.540 130.826 120.644 1.00 16.97  ? 179 LYS A NZ  1 
ATOM   3757 N N   . VAL B 2 180 ? 134.700 132.104 114.407 1.00 18.31  ? 180 VAL A N   1 
ATOM   3758 C CA  . VAL B 2 180 ? 135.717 131.397 113.639 1.00 18.31  ? 180 VAL A CA  1 
ATOM   3759 C C   . VAL B 2 180 ? 136.830 130.992 114.594 1.00 18.31  ? 180 VAL A C   1 
ATOM   3760 O O   . VAL B 2 180 ? 137.339 131.827 115.352 1.00 18.31  ? 180 VAL A O   1 
ATOM   3761 C CB  . VAL B 2 180 ? 136.259 132.264 112.490 1.00 18.31  ? 180 VAL A CB  1 
ATOM   3762 C CG1 . VAL B 2 180 ? 137.057 131.417 111.514 1.00 18.31  ? 180 VAL A CG1 1 
ATOM   3763 C CG2 . VAL B 2 180 ? 135.118 132.977 111.779 1.00 18.31  ? 180 VAL A CG2 1 
ATOM   3764 N N   . TRP B 2 181 ? 137.195 129.709 114.564 1.00 25.33  ? 181 TRP A N   1 
ATOM   3765 C CA  . TRP B 2 181 ? 138.224 129.149 115.441 1.00 25.33  ? 181 TRP A CA  1 
ATOM   3766 C C   . TRP B 2 181 ? 137.940 129.485 116.905 1.00 25.33  ? 181 TRP A C   1 
ATOM   3767 O O   . TRP B 2 181 ? 138.831 129.859 117.671 1.00 25.33  ? 181 TRP A O   1 
ATOM   3768 C CB  . TRP B 2 181 ? 139.618 129.623 115.026 1.00 25.33  ? 181 TRP A CB  1 
ATOM   3769 C CG  . TRP B 2 181 ? 140.036 129.148 113.664 1.00 25.33  ? 181 TRP A CG  1 
ATOM   3770 C CD1 . TRP B 2 181 ? 139.901 129.821 112.486 1.00 25.33  ? 181 TRP A CD1 1 
ATOM   3771 C CD2 . TRP B 2 181 ? 140.657 127.896 113.341 1.00 25.33  ? 181 TRP A CD2 1 
ATOM   3772 N NE1 . TRP B 2 181 ? 140.397 129.068 111.450 1.00 25.33  ? 181 TRP A NE1 1 
ATOM   3773 C CE2 . TRP B 2 181 ? 140.868 127.882 111.948 1.00 25.33  ? 181 TRP A CE2 1 
ATOM   3774 C CE3 . TRP B 2 181 ? 141.055 126.788 114.094 1.00 25.33  ? 181 TRP A CE3 1 
ATOM   3775 C CZ2 . TRP B 2 181 ? 141.458 126.803 111.293 1.00 25.33  ? 181 TRP A CZ2 1 
ATOM   3776 C CZ3 . TRP B 2 181 ? 141.641 125.718 113.442 1.00 25.33  ? 181 TRP A CZ3 1 
ATOM   3777 C CH2 . TRP B 2 181 ? 141.837 125.733 112.056 1.00 25.33  ? 181 TRP A CH2 1 
ATOM   3778 N N   . GLN B 2 182 ? 136.667 129.358 117.283 1.00 26.24  ? 182 GLN A N   1 
ATOM   3779 C CA  . GLN B 2 182 ? 136.182 129.603 118.642 1.00 26.24  ? 182 GLN A CA  1 
ATOM   3780 C C   . GLN B 2 182 ? 136.390 131.046 119.094 1.00 26.24  ? 182 GLN A C   1 
ATOM   3781 O O   . GLN B 2 182 ? 136.419 131.322 120.297 1.00 26.24  ? 182 GLN A O   1 
ATOM   3782 C CB  . GLN B 2 182 ? 136.824 128.640 119.649 1.00 26.24  ? 182 GLN A CB  1 
ATOM   3783 C CG  . GLN B 2 182 ? 136.402 127.191 119.478 1.00 26.24  ? 182 GLN A CG  1 
ATOM   3784 C CD  . GLN B 2 182 ? 134.930 126.970 119.769 1.00 26.24  ? 182 GLN A CD  1 
ATOM   3785 O OE1 . GLN B 2 182 ? 134.284 126.124 119.150 1.00 26.24  ? 182 GLN A OE1 1 
ATOM   3786 N NE2 . GLN B 2 182 ? 134.394 127.725 120.720 1.00 26.24  ? 182 GLN A NE2 1 
ATOM   3787 N N   . LEU B 2 183 ? 136.538 131.980 118.157 1.00 22.37  ? 183 LEU A N   1 
ATOM   3788 C CA  . LEU B 2 183 ? 136.629 133.400 118.472 1.00 22.37  ? 183 LEU A CA  1 
ATOM   3789 C C   . LEU B 2 183 ? 135.556 134.147 117.694 1.00 22.37  ? 183 LEU A C   1 
ATOM   3790 O O   . LEU B 2 183 ? 135.425 133.963 116.481 1.00 22.37  ? 183 LEU A O   1 
ATOM   3791 C CB  . LEU B 2 183 ? 138.017 133.960 118.146 1.00 22.37  ? 183 LEU A CB  1 
ATOM   3792 C CG  . LEU B 2 183 ? 139.081 133.886 119.248 1.00 22.37  ? 183 LEU A CG  1 
ATOM   3793 C CD1 . LEU B 2 183 ? 139.500 132.452 119.535 1.00 22.37  ? 183 LEU A CD1 1 
ATOM   3794 C CD2 . LEU B 2 183 ? 140.291 134.734 118.888 1.00 22.37  ? 183 LEU A CD2 1 
ATOM   3795 N N   . ASP B 2 184 ? 134.792 134.983 118.392 1.00 18.33  ? 184 ASP A N   1 
ATOM   3796 C CA  . ASP B 2 184 ? 133.677 135.703 117.789 1.00 18.33  ? 184 ASP A CA  1 
ATOM   3797 C C   . ASP B 2 184 ? 134.174 137.029 117.226 1.00 18.33  ? 184 ASP A C   1 
ATOM   3798 O O   . ASP B 2 184 ? 134.793 137.821 117.945 1.00 18.33  ? 184 ASP A O   1 
ATOM   3799 C CB  . ASP B 2 184 ? 132.567 135.932 118.814 1.00 18.33  ? 184 ASP A CB  1 
ATOM   3800 C CG  . ASP B 2 184 ? 131.332 136.563 118.204 1.00 18.33  ? 184 ASP A CG  1 
ATOM   3801 O OD1 . ASP B 2 184 ? 130.645 135.885 117.411 1.00 18.33  ? 184 ASP A OD1 1 
ATOM   3802 O OD2 . ASP B 2 184 ? 131.046 137.738 118.519 1.00 18.33  ? 184 ASP A OD2 1 
ATOM   3803 N N   . TYR B 2 185 ? 133.899 137.270 115.946 1.00 18.07  ? 185 TYR A N   1 
ATOM   3804 C CA  . TYR B 2 185 ? 134.350 138.468 115.256 1.00 18.07  ? 185 TYR A CA  1 
ATOM   3805 C C   . TYR B 2 185 ? 133.205 139.066 114.450 1.00 18.07  ? 185 TYR A C   1 
ATOM   3806 O O   . TYR B 2 185 ? 132.249 138.381 114.073 1.00 18.07  ? 185 TYR A O   1 
ATOM   3807 C CB  . TYR B 2 185 ? 135.544 138.169 114.338 1.00 18.07  ? 185 TYR A CB  1 
ATOM   3808 C CG  . TYR B 2 185 ? 136.848 137.973 115.078 1.00 18.07  ? 185 TYR A CG  1 
ATOM   3809 C CD1 . TYR B 2 185 ? 137.181 138.777 116.159 1.00 18.07  ? 185 TYR A CD1 1 
ATOM   3810 C CD2 . TYR B 2 185 ? 137.742 136.981 114.699 1.00 18.07  ? 185 TYR A CD2 1 
ATOM   3811 C CE1 . TYR B 2 185 ? 138.371 138.603 116.840 1.00 18.07  ? 185 TYR A CE1 1 
ATOM   3812 C CE2 . TYR B 2 185 ? 138.934 136.799 115.374 1.00 18.07  ? 185 TYR A CE2 1 
ATOM   3813 C CZ  . TYR B 2 185 ? 139.243 137.612 116.444 1.00 18.07  ? 185 TYR A CZ  1 
ATOM   3814 O OH  . TYR B 2 185 ? 140.428 137.436 117.119 1.00 18.07  ? 185 TYR A OH  1 
ATOM   3815 N N   . GLU B 2 186 ? 133.320 140.366 114.191 1.00 23.21  ? 186 GLU A N   1 
ATOM   3816 C CA  . GLU B 2 186 ? 132.318 141.130 113.462 1.00 23.21  ? 186 GLU A CA  1 
ATOM   3817 C C   . GLU B 2 186 ? 132.877 141.559 112.112 1.00 23.21  ? 186 GLU A C   1 
ATOM   3818 O O   . GLU B 2 186 ? 134.052 141.924 112.004 1.00 23.21  ? 186 GLU A O   1 
ATOM   3819 C CB  . GLU B 2 186 ? 131.881 142.359 114.266 1.00 23.21  ? 186 GLU A CB  1 
ATOM   3820 C CG  . GLU B 2 186 ? 130.787 143.187 113.612 1.00 23.21  ? 186 GLU A CG  1 
ATOM   3821 C CD  . GLU B 2 186 ? 130.415 144.408 114.431 1.00 23.21  ? 186 GLU A CD  1 
ATOM   3822 O OE1 . GLU B 2 186 ? 131.029 144.617 115.499 1.00 23.21  ? 186 GLU A OE1 1 
ATOM   3823 O OE2 . GLU B 2 186 ? 129.511 145.157 114.008 1.00 23.21  ? 186 GLU A OE2 1 
ATOM   3824 N N   . SER B 2 187 ? 132.031 141.514 111.086 1.00 20.83  ? 187 SER A N   1 
ATOM   3825 C CA  . SER B 2 187 ? 132.442 141.846 109.732 1.00 20.83  ? 187 SER A CA  1 
ATOM   3826 C C   . SER B 2 187 ? 132.273 143.340 109.466 1.00 20.83  ? 187 SER A C   1 
ATOM   3827 O O   . SER B 2 187 ? 131.768 144.099 110.298 1.00 20.83  ? 187 SER A O   1 
ATOM   3828 C CB  . SER B 2 187 ? 131.649 141.023 108.719 1.00 20.83  ? 187 SER A CB  1 
ATOM   3829 O OG  . SER B 2 187 ? 130.258 141.269 108.840 1.00 20.83  ? 187 SER A OG  1 
ATOM   3830 N N   . GLU B 2 188 ? 132.706 143.768 108.280 1.00 20.12  ? 188 GLU A N   1 
ATOM   3831 C CA  . GLU B 2 188 ? 132.589 145.150 107.828 1.00 20.12  ? 188 GLU A CA  1 
ATOM   3832 C C   . GLU B 2 188 ? 131.173 145.415 107.329 1.00 20.12  ? 188 GLU A C   1 
ATOM   3833 O O   . GLU B 2 188 ? 130.631 144.604 106.569 1.00 20.12  ? 188 GLU A O   1 
ATOM   3834 C CB  . GLU B 2 188 ? 133.593 145.441 106.720 1.00 20.12  ? 188 GLU A CB  1 
ATOM   3835 C CG  . GLU B 2 188 ? 133.654 146.897 106.288 1.00 20.12  ? 188 GLU A CG  1 
ATOM   3836 C CD  . GLU B 2 188 ? 134.766 147.163 105.293 1.00 20.12  ? 188 GLU A CD  1 
ATOM   3837 O OE1 . GLU B 2 188 ? 135.488 146.207 104.937 1.00 20.12  ? 188 GLU A OE1 1 
ATOM   3838 O OE2 . GLU B 2 188 ? 134.920 148.327 104.867 1.00 20.12  ? 188 GLU A OE2 1 
ATOM   3839 N N   . PRO B 2 189 ? 130.544 146.518 107.738 1.00 21.25  ? 189 PRO A N   1 
ATOM   3840 C CA  . PRO B 2 189 ? 129.179 146.802 107.280 1.00 21.25  ? 189 PRO A CA  1 
ATOM   3841 C C   . PRO B 2 189 ? 129.118 147.006 105.773 1.00 21.25  ? 189 PRO A C   1 
ATOM   3842 O O   . PRO B 2 189 ? 130.069 147.482 105.148 1.00 21.25  ? 189 PRO A O   1 
ATOM   3843 C CB  . PRO B 2 189 ? 128.812 148.086 108.035 1.00 21.25  ? 189 PRO A CB  1 
ATOM   3844 C CG  . PRO B 2 189 ? 130.123 148.705 108.397 1.00 21.25  ? 189 PRO A CG  1 
ATOM   3845 C CD  . PRO B 2 189 ? 131.048 147.555 108.653 1.00 21.25  ? 189 PRO A CD  1 
ATOM   3846 N N   . LEU B 2 190 ? 127.980 146.637 105.192 1.00 23.85  ? 190 LEU A N   1 
ATOM   3847 C CA  . LEU B 2 190 ? 127.764 146.701 103.753 1.00 23.85  ? 190 LEU A CA  1 
ATOM   3848 C C   . LEU B 2 190 ? 126.748 147.795 103.424 1.00 23.85  ? 190 LEU A C   1 
ATOM   3849 O O   . LEU B 2 190 ? 126.170 148.432 104.309 1.00 23.85  ? 190 LEU A O   1 
ATOM   3850 C CB  . LEU B 2 190 ? 127.321 145.333 103.225 1.00 23.85  ? 190 LEU A CB  1 
ATOM   3851 C CG  . LEU B 2 190 ? 127.555 145.021 101.744 1.00 23.85  ? 190 LEU A CG  1 
ATOM   3852 C CD1 . LEU B 2 190 ? 128.855 145.642 101.261 1.00 23.85  ? 190 LEU A CD1 1 
ATOM   3853 C CD2 . LEU B 2 190 ? 127.567 143.518 101.519 1.00 23.85  ? 190 LEU A CD2 1 
ATOM   3854 N N   . ASN B 2 191 ? 126.542 148.016 102.127 1.00 29.06  ? 191 ASN A N   1 
ATOM   3855 C CA  . ASN B 2 191 ? 125.697 149.083 101.595 1.00 29.06  ? 191 ASN A CA  1 
ATOM   3856 C C   . ASN B 2 191 ? 124.678 148.522 100.610 1.00 29.06  ? 191 ASN A C   1 
ATOM   3857 O O   . ASN B 2 191 ? 124.528 149.013 99.489  1.00 29.06  ? 191 ASN A O   1 
ATOM   3858 C CB  . ASN B 2 191 ? 126.541 150.163 100.922 1.00 29.06  ? 191 ASN A CB  1 
ATOM   3859 C CG  . ASN B 2 191 ? 127.270 151.042 101.917 1.00 29.06  ? 191 ASN A CG  1 
ATOM   3860 O OD1 . ASN B 2 191 ? 128.495 150.990 102.029 1.00 29.06  ? 191 ASN A OD1 1 
ATOM   3861 N ND2 . ASN B 2 191 ? 126.519 151.863 102.641 1.00 29.06  ? 191 ASN A ND2 1 
ATOM   3862 N N   . ILE B 2 192 ? 123.959 147.476 101.015 1.00 27.67  ? 192 ILE A N   1 
ATOM   3863 C CA  . ILE B 2 192 ? 123.108 146.751 100.075 1.00 27.67  ? 192 ILE A CA  1 
ATOM   3864 C C   . ILE B 2 192 ? 121.879 147.588 99.748  1.00 27.67  ? 192 ILE A C   1 
ATOM   3865 O O   . ILE B 2 192 ? 120.940 147.673 100.546 1.00 27.67  ? 192 ILE A O   1 
ATOM   3866 C CB  . ILE B 2 192 ? 122.708 145.372 100.630 1.00 27.67  ? 192 ILE A CB  1 
ATOM   3867 C CG1 . ILE B 2 192 ? 123.943 144.486 100.781 1.00 27.67  ? 192 ILE A CG1 1 
ATOM   3868 C CG2 . ILE B 2 192 ? 121.694 144.701 99.715  1.00 27.67  ? 192 ILE A CG2 1 
ATOM   3869 C CD1 . ILE B 2 192 ? 124.648 144.215 99.473  1.00 27.67  ? 192 ILE A CD1 1 
ATOM   3870 N N   . THR B 2 193 ? 121.875 148.205 98.570  1.00 31.47  ? 193 THR A N   1 
ATOM   3871 C CA  . THR B 2 193 ? 120.785 149.066 98.133  1.00 31.47  ? 193 THR A CA  1 
ATOM   3872 C C   . THR B 2 193 ? 120.228 148.556 96.812  1.00 31.47  ? 193 THR A C   1 
ATOM   3873 O O   . THR B 2 193 ? 120.985 148.195 95.905  1.00 31.47  ? 193 THR A O   1 
ATOM   3874 C CB  . THR B 2 193 ? 121.256 150.518 97.978  1.00 31.47  ? 193 THR A CB  1 
ATOM   3875 O OG1 . THR B 2 193 ? 121.865 150.957 99.198  1.00 31.47  ? 193 THR A OG1 1 
ATOM   3876 C CG2 . THR B 2 193 ? 120.083 151.431 97.649  1.00 31.47  ? 193 THR A CG2 1 
ATOM   3877 N N   . VAL B 2 194 ? 118.903 148.528 96.709  1.00 33.71  ? 194 VAL A N   1 
ATOM   3878 C CA  . VAL B 2 194 ? 118.222 148.082 95.502  1.00 33.71  ? 194 VAL A CA  1 
ATOM   3879 C C   . VAL B 2 194 ? 117.535 149.277 94.854  1.00 33.71  ? 194 VAL A C   1 
ATOM   3880 O O   . VAL B 2 194 ? 117.345 150.332 95.466  1.00 33.71  ? 194 VAL A O   1 
ATOM   3881 C CB  . VAL B 2 194 ? 117.208 146.956 95.790  1.00 33.71  ? 194 VAL A CB  1 
ATOM   3882 C CG1 . VAL B 2 194 ? 117.902 145.772 96.446  1.00 33.71  ? 194 VAL A CG1 1 
ATOM   3883 C CG2 . VAL B 2 194 ? 116.076 147.473 96.665  1.00 33.71  ? 194 VAL A CG2 1 
ATOM   3884 N N   . ILE B 2 195 ? 117.159 149.100 93.591  1.00 43.46  ? 195 ILE A N   1 
ATOM   3885 C CA  . ILE B 2 195 ? 116.493 150.153 92.837  1.00 43.46  ? 195 ILE A CA  1 
ATOM   3886 C C   . ILE B 2 195 ? 115.027 149.800 92.617  1.00 43.46  ? 195 ILE A C   1 
ATOM   3887 O O   . ILE B 2 195 ? 114.630 148.644 92.759  1.00 43.46  ? 195 ILE A O   1 
ATOM   3888 C CB  . ILE B 2 195 ? 117.200 150.408 91.495  1.00 43.46  ? 195 ILE A CB  1 
ATOM   3889 C CG1 . ILE B 2 195 ? 118.653 150.826 91.728  1.00 43.46  ? 195 ILE A CG1 1 
ATOM   3890 C CG2 . ILE B 2 195 ? 116.457 151.467 90.694  1.00 43.46  ? 195 ILE A CG2 1 
ATOM   3891 C CD1 . ILE B 2 195 ? 119.426 151.087 90.454  1.00 43.46  ? 195 ILE A CD1 1 
ATOM   3892 N N   . ASP C 1 27  ? 130.575 85.395  139.012 1.00 100.29 ? 98  ASP E N   1 
ATOM   3893 C CA  . ASP C 1 27  ? 130.116 86.756  138.758 1.00 100.29 ? 98  ASP E CA  1 
ATOM   3894 C C   . ASP C 1 27  ? 131.278 87.661  138.363 1.00 100.29 ? 98  ASP E C   1 
ATOM   3895 O O   . ASP C 1 27  ? 131.800 88.405  139.193 1.00 100.29 ? 98  ASP E O   1 
ATOM   3896 C CB  . ASP C 1 27  ? 129.403 87.318  139.989 1.00 100.29 ? 98  ASP E CB  1 
ATOM   3897 C CG  . ASP C 1 27  ? 128.206 86.484  140.400 1.00 100.29 ? 98  ASP E CG  1 
ATOM   3898 O OD1 . ASP C 1 27  ? 127.565 85.883  139.513 1.00 100.29 ? 98  ASP E OD1 1 
ATOM   3899 O OD2 . ASP C 1 27  ? 127.906 86.429  141.612 1.00 100.29 ? 98  ASP E OD2 1 
ATOM   3900 N N   . PRO C 1 28  ? 131.685 87.594  137.098 1.00 100.88 ? 99  PRO E N   1 
ATOM   3901 C CA  . PRO C 1 28  ? 132.805 88.419  136.637 1.00 100.88 ? 99  PRO E CA  1 
ATOM   3902 C C   . PRO C 1 28  ? 132.443 89.896  136.607 1.00 100.88 ? 99  PRO E C   1 
ATOM   3903 O O   . PRO C 1 28  ? 131.280 90.284  136.471 1.00 100.88 ? 99  PRO E O   1 
ATOM   3904 C CB  . PRO C 1 28  ? 133.080 87.887  135.227 1.00 100.88 ? 99  PRO E CB  1 
ATOM   3905 C CG  . PRO C 1 28  ? 131.767 87.340  134.780 1.00 100.88 ? 99  PRO E CG  1 
ATOM   3906 C CD  . PRO C 1 28  ? 131.119 86.772  136.013 1.00 100.88 ? 99  PRO E CD  1 
ATOM   3907 N N   . THR C 1 29  ? 133.473 90.726  136.737 1.00 96.96  ? 100 THR E N   1 
ATOM   3908 C CA  . THR C 1 29  ? 133.342 92.175  136.668 1.00 96.96  ? 100 THR E CA  1 
ATOM   3909 C C   . THR C 1 29  ? 133.876 92.654  135.326 1.00 96.96  ? 100 THR E C   1 
ATOM   3910 O O   . THR C 1 29  ? 134.990 92.290  134.933 1.00 96.96  ? 100 THR E O   1 
ATOM   3911 C CB  . THR C 1 29  ? 134.097 92.853  137.814 1.00 96.96  ? 100 THR E CB  1 
ATOM   3912 O OG1 . THR C 1 29  ? 133.594 92.378  139.069 1.00 96.96  ? 100 THR E OG1 1 
ATOM   3913 C CG2 . THR C 1 29  ? 133.927 94.364  137.746 1.00 96.96  ? 100 THR E CG2 1 
ATOM   3914 N N   . LEU C 1 30  ? 133.082 93.461  134.627 1.00 93.29  ? 101 LEU E N   1 
ATOM   3915 C CA  . LEU C 1 30  ? 133.417 93.944  133.294 1.00 93.29  ? 101 LEU E CA  1 
ATOM   3916 C C   . LEU C 1 30  ? 133.722 95.434  133.349 1.00 93.29  ? 101 LEU E C   1 
ATOM   3917 O O   . LEU C 1 30  ? 132.950 96.209  133.923 1.00 93.29  ? 101 LEU E O   1 
ATOM   3918 C CB  . LEU C 1 30  ? 132.273 93.678  132.313 1.00 93.29  ? 101 LEU E CB  1 
ATOM   3919 C CG  . LEU C 1 30  ? 131.744 92.245  132.240 1.00 93.29  ? 101 LEU E CG  1 
ATOM   3920 C CD1 . LEU C 1 30  ? 130.669 92.134  131.173 1.00 93.29  ? 101 LEU E CD1 1 
ATOM   3921 C CD2 . LEU C 1 30  ? 132.874 91.266  131.971 1.00 93.29  ? 101 LEU E CD2 1 
ATOM   3922 N N   . GLU C 1 31  ? 134.847 95.829  132.754 1.00 90.51  ? 102 GLU E N   1 
ATOM   3923 C CA  . GLU C 1 31  ? 135.240 97.233  132.661 1.00 90.51  ? 102 GLU E CA  1 
ATOM   3924 C C   . GLU C 1 31  ? 135.698 97.507  131.235 1.00 90.51  ? 102 GLU E C   1 
ATOM   3925 O O   . GLU C 1 31  ? 136.778 97.063  130.834 1.00 90.51  ? 102 GLU E O   1 
ATOM   3926 C CB  . GLU C 1 31  ? 136.346 97.569  133.667 1.00 90.51  ? 102 GLU E CB  1 
ATOM   3927 C CG  . GLU C 1 31  ? 135.934 97.442  135.132 1.00 90.51  ? 102 GLU E CG  1 
ATOM   3928 C CD  . GLU C 1 31  ? 137.050 97.816  136.096 1.00 90.51  ? 102 GLU E CD  1 
ATOM   3929 O OE1 . GLU C 1 31  ? 138.157 98.156  135.628 1.00 90.51  ? 102 GLU E OE1 1 
ATOM   3930 O OE2 . GLU C 1 31  ? 136.820 97.770  137.324 1.00 90.51  ? 102 GLU E OE2 1 
ATOM   3931 N N   . LEU C 1 32  ? 134.884 98.224  130.466 1.00 81.21  ? 103 LEU E N   1 
ATOM   3932 C CA  . LEU C 1 32  ? 135.218 98.579  129.091 1.00 81.21  ? 103 LEU E CA  1 
ATOM   3933 C C   . LEU C 1 32  ? 135.607 100.050 129.044 1.00 81.21  ? 103 LEU E C   1 
ATOM   3934 O O   . LEU C 1 32  ? 134.820 100.917 129.440 1.00 81.21  ? 103 LEU E O   1 
ATOM   3935 C CB  . LEU C 1 32  ? 134.049 98.298  128.147 1.00 81.21  ? 103 LEU E CB  1 
ATOM   3936 C CG  . LEU C 1 32  ? 134.332 98.521  126.661 1.00 81.21  ? 103 LEU E CG  1 
ATOM   3937 C CD1 . LEU C 1 32  ? 135.527 97.694  126.223 1.00 81.21  ? 103 LEU E CD1 1 
ATOM   3938 C CD2 . LEU C 1 32  ? 133.108 98.185  125.827 1.00 81.21  ? 103 LEU E CD2 1 
ATOM   3939 N N   . LEU C 1 33  ? 136.813 100.327 128.552 1.00 66.62  ? 104 LEU E N   1 
ATOM   3940 C CA  . LEU C 1 33  ? 137.360 101.674 128.519 1.00 66.62  ? 104 LEU E CA  1 
ATOM   3941 C C   . LEU C 1 33  ? 137.939 101.960 127.142 1.00 66.62  ? 104 LEU E C   1 
ATOM   3942 O O   . LEU C 1 33  ? 138.340 101.047 126.415 1.00 66.62  ? 104 LEU E O   1 
ATOM   3943 C CB  . LEU C 1 33  ? 138.452 101.866 129.584 1.00 66.62  ? 104 LEU E CB  1 
ATOM   3944 C CG  . LEU C 1 33  ? 138.131 101.417 131.011 1.00 66.62  ? 104 LEU E CG  1 
ATOM   3945 C CD1 . LEU C 1 33  ? 139.340 101.588 131.919 1.00 66.62  ? 104 LEU E CD1 1 
ATOM   3946 C CD2 . LEU C 1 33  ? 136.937 102.178 131.559 1.00 66.62  ? 104 LEU E CD2 1 
ATOM   3947 N N   . HIS C 1 34  ? 137.979 103.243 126.791 1.00 62.61  ? 105 HIS E N   1 
ATOM   3948 C CA  . HIS C 1 34  ? 138.568 103.708 125.543 1.00 62.61  ? 105 HIS E CA  1 
ATOM   3949 C C   . HIS C 1 34  ? 139.732 104.636 125.859 1.00 62.61  ? 105 HIS E C   1 
ATOM   3950 O O   . HIS C 1 34  ? 139.611 105.519 126.716 1.00 62.61  ? 105 HIS E O   1 
ATOM   3951 C CB  . HIS C 1 34  ? 137.530 104.420 124.670 1.00 62.61  ? 105 HIS E CB  1 
ATOM   3952 C CG  . HIS C 1 34  ? 136.563 105.262 125.441 1.00 62.61  ? 105 HIS E CG  1 
ATOM   3953 N ND1 . HIS C 1 34  ? 135.463 104.734 126.084 1.00 62.61  ? 105 HIS E ND1 1 
ATOM   3954 C CD2 . HIS C 1 34  ? 136.523 106.597 125.666 1.00 62.61  ? 105 HIS E CD2 1 
ATOM   3955 C CE1 . HIS C 1 34  ? 134.792 105.706 126.675 1.00 62.61  ? 105 HIS E CE1 1 
ATOM   3956 N NE2 . HIS C 1 34  ? 135.414 106.846 126.437 1.00 62.61  ? 105 HIS E NE2 1 
ATOM   3957 N N   . SER C 1 35  ? 140.852 104.431 125.172 1.00 62.49  ? 106 SER E N   1 
ATOM   3958 C CA  . SER C 1 35  ? 142.061 105.191 125.455 1.00 62.49  ? 106 SER E CA  1 
ATOM   3959 C C   . SER C 1 35  ? 141.892 106.656 125.068 1.00 62.49  ? 106 SER E C   1 
ATOM   3960 O O   . SER C 1 35  ? 141.086 107.008 124.202 1.00 62.49  ? 106 SER E O   1 
ATOM   3961 C CB  . SER C 1 35  ? 143.256 104.594 124.715 1.00 62.49  ? 106 SER E CB  1 
ATOM   3962 O OG  . SER C 1 35  ? 144.441 105.323 124.986 1.00 62.49  ? 106 SER E OG  1 
ATOM   3963 N N   . SER C 1 36  ? 142.670 107.512 125.723 1.00 63.00  ? 107 SER E N   1 
ATOM   3964 C CA  . SER C 1 36  ? 142.585 108.944 125.494 1.00 63.00  ? 107 SER E CA  1 
ATOM   3965 C C   . SER C 1 36  ? 143.332 109.342 124.227 1.00 63.00  ? 107 SER E C   1 
ATOM   3966 O O   . SER C 1 36  ? 144.389 108.797 123.899 1.00 63.00  ? 107 SER E O   1 
ATOM   3967 C CB  . SER C 1 36  ? 143.148 109.713 126.689 1.00 63.00  ? 107 SER E CB  1 
ATOM   3968 O OG  . SER C 1 36  ? 143.037 111.112 126.491 1.00 63.00  ? 107 SER E OG  1 
ATOM   3969 N N   . CYS C 1 37  ? 142.761 110.307 123.514 1.00 73.32  ? 108 CYS E N   1 
ATOM   3970 C CA  . CYS C 1 37  ? 143.372 110.865 122.315 1.00 73.32  ? 108 CYS E CA  1 
ATOM   3971 C C   . CYS C 1 37  ? 144.455 111.860 122.716 1.00 73.32  ? 108 CYS E C   1 
ATOM   3972 O O   . CYS C 1 37  ? 144.157 112.899 123.316 1.00 73.32  ? 108 CYS E O   1 
ATOM   3973 C CB  . CYS C 1 37  ? 142.301 111.540 121.465 1.00 73.32  ? 108 CYS E CB  1 
ATOM   3974 S SG  . CYS C 1 37  ? 140.907 112.076 122.483 1.00 73.32  ? 108 CYS E SG  1 
ATOM   3975 N N   . ASP C 1 38  ? 145.704 111.549 122.388 1.00 81.32  ? 109 ASP E N   1 
ATOM   3976 C CA  . ASP C 1 38  ? 146.815 112.413 122.769 1.00 81.32  ? 109 ASP E CA  1 
ATOM   3977 C C   . ASP C 1 38  ? 146.893 113.603 121.820 1.00 81.32  ? 109 ASP E C   1 
ATOM   3978 O O   . ASP C 1 38  ? 147.076 113.408 120.613 1.00 81.32  ? 109 ASP E O   1 
ATOM   3979 C CB  . ASP C 1 38  ? 148.126 111.635 122.749 1.00 81.32  ? 109 ASP E CB  1 
ATOM   3980 C CG  . ASP C 1 38  ? 149.224 112.311 123.553 1.00 81.32  ? 109 ASP E CG  1 
ATOM   3981 O OD1 . ASP C 1 38  ? 149.231 113.557 123.640 1.00 81.32  ? 109 ASP E OD1 1 
ATOM   3982 O OD2 . ASP C 1 38  ? 150.084 111.591 124.102 1.00 81.32  ? 109 ASP E OD2 1 
ATOM   3983 N N   . PRO C 1 39  ? 146.762 114.838 122.312 1.00 80.50  ? 110 PRO E N   1 
ATOM   3984 C CA  . PRO C 1 39  ? 146.863 115.992 121.406 1.00 80.50  ? 110 PRO E CA  1 
ATOM   3985 C C   . PRO C 1 39  ? 148.292 116.344 121.036 1.00 80.50  ? 110 PRO E C   1 
ATOM   3986 O O   . PRO C 1 39  ? 148.523 116.869 119.940 1.00 80.50  ? 110 PRO E O   1 
ATOM   3987 C CB  . PRO C 1 39  ? 146.192 117.117 122.204 1.00 80.50  ? 110 PRO E CB  1 
ATOM   3988 C CG  . PRO C 1 39  ? 146.444 116.748 123.628 1.00 80.50  ? 110 PRO E CG  1 
ATOM   3989 C CD  . PRO C 1 39  ? 146.416 115.240 123.687 1.00 80.50  ? 110 PRO E CD  1 
ATOM   3990 N N   . ASN C 1 40  ? 149.260 116.072 121.913 1.00 85.09  ? 111 ASN E N   1 
ATOM   3991 C CA  . ASN C 1 40  ? 150.648 116.411 121.619 1.00 85.09  ? 111 ASN E CA  1 
ATOM   3992 C C   . ASN C 1 40  ? 151.306 115.347 120.749 1.00 85.09  ? 111 ASN E C   1 
ATOM   3993 O O   . ASN C 1 40  ? 151.900 115.662 119.712 1.00 85.09  ? 111 ASN E O   1 
ATOM   3994 C CB  . ASN C 1 40  ? 151.429 116.600 122.922 1.00 85.09  ? 111 ASN E CB  1 
ATOM   3995 C CG  . ASN C 1 40  ? 152.863 117.034 122.685 1.00 85.09  ? 111 ASN E CG  1 
ATOM   3996 O OD1 . ASN C 1 40  ? 153.185 117.617 121.650 1.00 85.09  ? 111 ASN E OD1 1 
ATOM   3997 N ND2 . ASN C 1 40  ? 153.733 116.750 123.648 1.00 85.09  ? 111 ASN E ND2 1 
ATOM   3998 N N   . ALA C 1 41  ? 151.211 114.084 121.156 1.00 94.24  ? 112 ALA E N   1 
ATOM   3999 C CA  . ALA C 1 41  ? 151.790 113.002 120.373 1.00 94.24  ? 112 ALA E CA  1 
ATOM   4000 C C   . ALA C 1 41  ? 150.965 112.751 119.118 1.00 94.24  ? 112 ALA E C   1 
ATOM   4001 O O   . ALA C 1 41  ? 149.732 112.816 119.139 1.00 94.24  ? 112 ALA E O   1 
ATOM   4002 C CB  . ALA C 1 41  ? 151.877 111.726 121.211 1.00 94.24  ? 112 ALA E CB  1 
ATOM   4003 N N   . PHE C 1 42  ? 151.655 112.462 118.014 1.00 104.76 ? 113 PHE E N   1 
ATOM   4004 C CA  . PHE C 1 42  ? 151.000 112.191 116.734 1.00 104.76 ? 113 PHE E CA  1 
ATOM   4005 C C   . PHE C 1 42  ? 150.530 110.739 116.728 1.00 104.76 ? 113 PHE E C   1 
ATOM   4006 O O   . PHE C 1 42  ? 151.177 109.836 116.192 1.00 104.76 ? 113 PHE E O   1 
ATOM   4007 C CB  . PHE C 1 42  ? 151.941 112.486 115.573 1.00 104.76 ? 113 PHE E CB  1 
ATOM   4008 C CG  . PHE C 1 42  ? 152.269 113.944 115.413 1.00 104.76 ? 113 PHE E CG  1 
ATOM   4009 C CD1 . PHE C 1 42  ? 151.411 114.918 115.895 1.00 104.76 ? 113 PHE E CD1 1 
ATOM   4010 C CD2 . PHE C 1 42  ? 153.435 114.339 114.778 1.00 104.76 ? 113 PHE E CD2 1 
ATOM   4011 C CE1 . PHE C 1 42  ? 151.710 116.260 115.749 1.00 104.76 ? 113 PHE E CE1 1 
ATOM   4012 C CE2 . PHE C 1 42  ? 153.739 115.679 114.628 1.00 104.76 ? 113 PHE E CE2 1 
ATOM   4013 C CZ  . PHE C 1 42  ? 152.875 116.641 115.114 1.00 104.76 ? 113 PHE E CZ  1 
ATOM   4014 N N   . HIS C 1 43  ? 149.371 110.518 117.344 1.00 101.82 ? 114 HIS E N   1 
ATOM   4015 C CA  . HIS C 1 43  ? 148.764 109.198 117.433 1.00 101.82 ? 114 HIS E CA  1 
ATOM   4016 C C   . HIS C 1 43  ? 147.336 109.273 116.916 1.00 101.82 ? 114 HIS E C   1 
ATOM   4017 O O   . HIS C 1 43  ? 146.609 110.226 117.211 1.00 101.82 ? 114 HIS E O   1 
ATOM   4018 C CB  . HIS C 1 43  ? 148.781 108.675 118.875 1.00 101.82 ? 114 HIS E CB  1 
ATOM   4019 C CG  . HIS C 1 43  ? 148.676 107.186 118.980 1.00 101.82 ? 114 HIS E CG  1 
ATOM   4020 N ND1 . HIS C 1 43  ? 149.615 106.334 118.438 1.00 101.82 ? 114 HIS E ND1 1 
ATOM   4021 C CD2 . HIS C 1 43  ? 147.747 106.396 119.568 1.00 101.82 ? 114 HIS E CD2 1 
ATOM   4022 C CE1 . HIS C 1 43  ? 149.267 105.084 118.686 1.00 101.82 ? 114 HIS E CE1 1 
ATOM   4023 N NE2 . HIS C 1 43  ? 148.137 105.094 119.370 1.00 101.82 ? 114 HIS E NE2 1 
ATOM   4024 N N   . SER C 1 44  ? 146.935 108.261 116.141 1.00 94.02  ? 115 SER E N   1 
ATOM   4025 C CA  . SER C 1 44  ? 145.619 108.249 115.515 1.00 94.02  ? 115 SER E CA  1 
ATOM   4026 C C   . SER C 1 44  ? 144.847 106.960 115.771 1.00 94.02  ? 115 SER E C   1 
ATOM   4027 O O   . SER C 1 44  ? 143.859 106.698 115.075 1.00 94.02  ? 115 SER E O   1 
ATOM   4028 C CB  . SER C 1 44  ? 145.743 108.485 114.005 1.00 94.02  ? 115 SER E CB  1 
ATOM   4029 O OG  . SER C 1 44  ? 144.471 108.472 113.380 1.00 94.02  ? 115 SER E OG  1 
ATOM   4030 N N   . THR C 1 45  ? 145.265 106.149 116.740 1.00 90.29  ? 116 THR E N   1 
ATOM   4031 C CA  . THR C 1 45  ? 144.590 104.901 117.070 1.00 90.29  ? 116 THR E CA  1 
ATOM   4032 C C   . THR C 1 45  ? 144.114 104.951 118.514 1.00 90.29  ? 116 THR E C   1 
ATOM   4033 O O   . THR C 1 45  ? 144.891 105.281 119.416 1.00 90.29  ? 116 THR E O   1 
ATOM   4034 C CB  . THR C 1 45  ? 145.513 103.697 116.861 1.00 90.29  ? 116 THR E CB  1 
ATOM   4035 O OG1 . THR C 1 45  ? 146.648 103.805 117.728 1.00 90.29  ? 116 THR E OG1 1 
ATOM   4036 C CG2 . THR C 1 45  ? 145.988 103.632 115.417 1.00 90.29  ? 116 THR E CG2 1 
ATOM   4037 N N   . ILE C 1 46  ? 142.844 104.624 118.728 1.00 77.48  ? 117 ILE E N   1 
ATOM   4038 C CA  . ILE C 1 46  ? 142.263 104.576 120.063 1.00 77.48  ? 117 ILE E CA  1 
ATOM   4039 C C   . ILE C 1 46  ? 142.283 103.133 120.546 1.00 77.48  ? 117 ILE E C   1 
ATOM   4040 O O   . ILE C 1 46  ? 141.900 102.214 119.810 1.00 77.48  ? 117 ILE E O   1 
ATOM   4041 C CB  . ILE C 1 46  ? 140.834 105.143 120.063 1.00 77.48  ? 117 ILE E CB  1 
ATOM   4042 C CG1 . ILE C 1 46  ? 140.838 106.587 119.556 1.00 77.48  ? 117 ILE E CG1 1 
ATOM   4043 C CG2 . ILE C 1 46  ? 140.227 105.069 121.457 1.00 77.48  ? 117 ILE E CG2 1 
ATOM   4044 C CD1 . ILE C 1 46  ? 139.471 107.233 119.536 1.00 77.48  ? 117 ILE E CD1 1 
ATOM   4045 N N   . GLN C 1 47  ? 142.742 102.930 121.779 1.00 80.96  ? 118 GLN E N   1 
ATOM   4046 C CA  . GLN C 1 47  ? 142.901 101.599 122.354 1.00 80.96  ? 118 GLN E CA  1 
ATOM   4047 C C   . GLN C 1 47  ? 141.685 101.285 123.218 1.00 80.96  ? 118 GLN E C   1 
ATOM   4048 O O   . GLN C 1 47  ? 141.491 101.893 124.276 1.00 80.96  ? 118 GLN E O   1 
ATOM   4049 C CB  . GLN C 1 47  ? 144.190 101.516 123.169 1.00 80.96  ? 118 GLN E CB  1 
ATOM   4050 C CG  . GLN C 1 47  ? 145.401 102.141 122.493 1.00 80.96  ? 118 GLN E CG  1 
ATOM   4051 C CD  . GLN C 1 47  ? 145.857 101.366 121.274 1.00 80.96  ? 118 GLN E CD  1 
ATOM   4052 O OE1 . GLN C 1 47  ? 145.572 100.177 121.138 1.00 80.96  ? 118 GLN E OE1 1 
ATOM   4053 N NE2 . GLN C 1 47  ? 146.571 102.038 120.379 1.00 80.96  ? 118 GLN E NE2 1 
ATOM   4054 N N   . LEU C 1 48  ? 140.870 100.336 122.767 1.00 79.06  ? 119 LEU E N   1 
ATOM   4055 C CA  . LEU C 1 48  ? 139.737 99.844  123.540 1.00 79.06  ? 119 LEU E CA  1 
ATOM   4056 C C   . LEU C 1 48  ? 140.195 98.666  124.391 1.00 79.06  ? 119 LEU E C   1 
ATOM   4057 O O   . LEU C 1 48  ? 140.725 97.683  123.862 1.00 79.06  ? 119 LEU E O   1 
ATOM   4058 C CB  . LEU C 1 48  ? 138.590 99.427  122.621 1.00 79.06  ? 119 LEU E CB  1 
ATOM   4059 C CG  . LEU C 1 48  ? 137.637 100.517 122.131 1.00 79.06  ? 119 LEU E CG  1 
ATOM   4060 C CD1 . LEU C 1 48  ? 136.636 99.940  121.143 1.00 79.06  ? 119 LEU E CD1 1 
ATOM   4061 C CD2 . LEU C 1 48  ? 136.917 101.150 123.306 1.00 79.06  ? 119 LEU E CD2 1 
ATOM   4062 N N   . TYR C 1 49  ? 139.994 98.769  125.702 1.00 85.82  ? 120 TYR E N   1 
ATOM   4063 C CA  . TYR C 1 49  ? 140.377 97.723  126.642 1.00 85.82  ? 120 TYR E CA  1 
ATOM   4064 C C   . TYR C 1 49  ? 139.132 97.205  127.344 1.00 85.82  ? 120 TYR E C   1 
ATOM   4065 O O   . TYR C 1 49  ? 138.410 97.975  127.987 1.00 85.82  ? 120 TYR E O   1 
ATOM   4066 C CB  . TYR C 1 49  ? 141.385 98.242  127.670 1.00 85.82  ? 120 TYR E CB  1 
ATOM   4067 C CG  . TYR C 1 49  ? 142.738 98.604  127.100 1.00 85.82  ? 120 TYR E CG  1 
ATOM   4068 C CD1 . TYR C 1 49  ? 143.651 97.619  126.748 1.00 85.82  ? 120 TYR E CD1 1 
ATOM   4069 C CD2 . TYR C 1 49  ? 143.109 99.931  126.933 1.00 85.82  ? 120 TYR E CD2 1 
ATOM   4070 C CE1 . TYR C 1 49  ? 144.892 97.946  126.234 1.00 85.82  ? 120 TYR E CE1 1 
ATOM   4071 C CE2 . TYR C 1 49  ? 144.347 100.268 126.421 1.00 85.82  ? 120 TYR E CE2 1 
ATOM   4072 C CZ  . TYR C 1 49  ? 145.234 99.272  126.072 1.00 85.82  ? 120 TYR E CZ  1 
ATOM   4073 O OH  . TYR C 1 49  ? 146.468 99.603  125.561 1.00 85.82  ? 120 TYR E OH  1 
ATOM   4074 N N   . CYS C 1 50  ? 138.889 95.903  127.231 1.00 99.29  ? 121 CYS E N   1 
ATOM   4075 C CA  . CYS C 1 50  ? 137.803 95.237  127.943 1.00 99.29  ? 121 CYS E CA  1 
ATOM   4076 C C   . CYS C 1 50  ? 138.429 94.323  128.989 1.00 99.29  ? 121 CYS E C   1 
ATOM   4077 O O   . CYS C 1 50  ? 139.030 93.300  128.645 1.00 99.29  ? 121 CYS E O   1 
ATOM   4078 C CB  . CYS C 1 50  ? 136.905 94.459  126.982 1.00 99.29  ? 121 CYS E CB  1 
ATOM   4079 S SG  . CYS C 1 50  ? 135.383 93.822  127.732 1.00 99.29  ? 121 CYS E SG  1 
ATOM   4080 N N   . PHE C 1 51  ? 138.309 94.703  130.259 1.00 95.54  ? 122 PHE E N   1 
ATOM   4081 C CA  . PHE C 1 51  ? 138.843 93.932  131.371 1.00 95.54  ? 122 PHE E CA  1 
ATOM   4082 C C   . PHE C 1 51  ? 137.735 93.072  131.963 1.00 95.54  ? 122 PHE E C   1 
ATOM   4083 O O   . PHE C 1 51  ? 136.650 93.577  132.275 1.00 95.54  ? 122 PHE E O   1 
ATOM   4084 C CB  . PHE C 1 51  ? 139.419 94.847  132.453 1.00 95.54  ? 122 PHE E CB  1 
ATOM   4085 C CG  . PHE C 1 51  ? 140.419 95.846  131.944 1.00 95.54  ? 122 PHE E CG  1 
ATOM   4086 C CD1 . PHE C 1 51  ? 141.749 95.497  131.785 1.00 95.54  ? 122 PHE E CD1 1 
ATOM   4087 C CD2 . PHE C 1 51  ? 140.032 97.141  131.643 1.00 95.54  ? 122 PHE E CD2 1 
ATOM   4088 C CE1 . PHE C 1 51  ? 142.673 96.416  131.323 1.00 95.54  ? 122 PHE E CE1 1 
ATOM   4089 C CE2 . PHE C 1 51  ? 140.950 98.065  131.182 1.00 95.54  ? 122 PHE E CE2 1 
ATOM   4090 C CZ  . PHE C 1 51  ? 142.272 97.702  131.022 1.00 95.54  ? 122 PHE E CZ  1 
ATOM   4091 N N   . ILE C 1 52  ? 138.013 91.780  132.117 1.00 104.84 ? 123 ILE E N   1 
ATOM   4092 C CA  . ILE C 1 52  ? 137.086 90.831  132.721 1.00 104.84 ? 123 ILE E CA  1 
ATOM   4093 C C   . ILE C 1 52  ? 137.780 90.226  133.930 1.00 104.84 ? 123 ILE E C   1 
ATOM   4094 O O   . ILE C 1 52  ? 138.850 89.617  133.797 1.00 104.84 ? 123 ILE E O   1 
ATOM   4095 C CB  . ILE C 1 52  ? 136.653 89.736  131.732 1.00 104.84 ? 123 ILE E CB  1 
ATOM   4096 C CG1 . ILE C 1 52  ? 136.071 90.352  130.457 1.00 104.84 ? 123 ILE E CG1 1 
ATOM   4097 C CG2 . ILE C 1 52  ? 135.641 88.804  132.381 1.00 104.84 ? 123 ILE E CG2 1 
ATOM   4098 C CD1 . ILE C 1 52  ? 137.077 90.541  129.338 1.00 104.84 ? 123 ILE E CD1 1 
ATOM   4099 N N   . TYR C 1 53  ? 137.174 90.387  135.103 1.00 102.88 ? 124 TYR E N   1 
ATOM   4100 C CA  . TYR C 1 53  ? 137.751 89.933  136.360 1.00 102.88 ? 124 TYR E CA  1 
ATOM   4101 C C   . TYR C 1 53  ? 136.919 88.799  136.943 1.00 102.88 ? 124 TYR E C   1 
ATOM   4102 O O   . TYR C 1 53  ? 135.686 88.860  136.951 1.00 102.88 ? 124 TYR E O   1 
ATOM   4103 C CB  . TYR C 1 53  ? 137.838 91.079  137.372 1.00 102.88 ? 124 TYR E CB  1 
ATOM   4104 C CG  . TYR C 1 53  ? 138.588 92.294  136.874 1.00 102.88 ? 124 TYR E CG  1 
ATOM   4105 C CD1 . TYR C 1 53  ? 139.973 92.359  136.948 1.00 102.88 ? 124 TYR E CD1 1 
ATOM   4106 C CD2 . TYR C 1 53  ? 137.910 93.381  136.338 1.00 102.88 ? 124 TYR E CD2 1 
ATOM   4107 C CE1 . TYR C 1 53  ? 140.662 93.468  136.497 1.00 102.88 ? 124 TYR E CE1 1 
ATOM   4108 C CE2 . TYR C 1 53  ? 138.590 94.495  135.885 1.00 102.88 ? 124 TYR E CE2 1 
ATOM   4109 C CZ  . TYR C 1 53  ? 139.966 94.533  135.966 1.00 102.88 ? 124 TYR E CZ  1 
ATOM   4110 O OH  . TYR C 1 53  ? 140.648 95.641  135.516 1.00 102.88 ? 124 TYR E OH  1 
ATOM   4111 N N   . GLY C 1 54  ? 137.602 87.769  137.433 1.00 105.85 ? 125 GLY E N   1 
ATOM   4112 C CA  . GLY C 1 54  ? 136.934 86.660  138.094 1.00 105.85 ? 125 GLY E CA  1 
ATOM   4113 C C   . GLY C 1 54  ? 136.044 85.820  137.203 1.00 105.85 ? 125 GLY E C   1 
ATOM   4114 O O   . GLY C 1 54  ? 134.935 85.454  137.613 1.00 105.85 ? 125 GLY E O   1 
ATOM   4115 N N   . HIS C 1 55  ? 136.499 85.504  135.995 1.00 112.02 ? 126 HIS E N   1 
ATOM   4116 C CA  . HIS C 1 55  ? 135.742 84.655  135.089 1.00 112.02 ? 126 HIS E CA  1 
ATOM   4117 C C   . HIS C 1 55  ? 136.154 83.196  135.292 1.00 112.02 ? 126 HIS E C   1 
ATOM   4118 O O   . HIS C 1 55  ? 136.858 82.851  136.245 1.00 112.02 ? 126 HIS E O   1 
ATOM   4119 C CB  . HIS C 1 55  ? 135.930 85.116  133.646 1.00 112.02 ? 126 HIS E CB  1 
ATOM   4120 C CG  . HIS C 1 55  ? 137.362 85.287  133.246 1.00 112.02 ? 126 HIS E CG  1 
ATOM   4121 N ND1 . HIS C 1 55  ? 137.970 86.522  133.168 1.00 112.02 ? 126 HIS E ND1 1 
ATOM   4122 C CD2 . HIS C 1 55  ? 138.306 84.381  132.898 1.00 112.02 ? 126 HIS E CD2 1 
ATOM   4123 C CE1 . HIS C 1 55  ? 139.226 86.369  132.790 1.00 112.02 ? 126 HIS E CE1 1 
ATOM   4124 N NE2 . HIS C 1 55  ? 139.455 85.080  132.619 1.00 112.02 ? 126 HIS E NE2 1 
ATOM   4125 N N   . ILE C 1 56  ? 135.717 82.321  134.390 1.00 121.93 ? 127 ILE E N   1 
ATOM   4126 C CA  . ILE C 1 56  ? 135.950 80.885  134.499 1.00 121.93 ? 127 ILE E CA  1 
ATOM   4127 C C   . ILE C 1 56  ? 137.174 80.520  133.671 1.00 121.93 ? 127 ILE E C   1 
ATOM   4128 O O   . ILE C 1 56  ? 137.295 80.934  132.510 1.00 121.93 ? 127 ILE E O   1 
ATOM   4129 C CB  . ILE C 1 56  ? 134.718 80.086  134.043 1.00 121.93 ? 127 ILE E CB  1 
ATOM   4130 C CG1 . ILE C 1 56  ? 133.487 80.496  134.854 1.00 121.93 ? 127 ILE E CG1 1 
ATOM   4131 C CG2 . ILE C 1 56  ? 134.970 78.591  134.175 1.00 121.93 ? 127 ILE E CG2 1 
ATOM   4132 C CD1 . ILE C 1 56  ? 133.634 80.272  136.343 1.00 121.93 ? 127 ILE E CD1 1 
ATOM   4133 N N   . LEU C 1 57  ? 138.082 79.752  134.268 1.00 127.07 ? 128 LEU E N   1 
ATOM   4134 C CA  . LEU C 1 57  ? 139.283 79.318  133.567 1.00 127.07 ? 128 LEU E CA  1 
ATOM   4135 C C   . LEU C 1 57  ? 138.928 78.387  132.413 1.00 127.07 ? 128 LEU E C   1 
ATOM   4136 O O   . LEU C 1 57  ? 138.035 77.543  132.526 1.00 127.07 ? 128 LEU E O   1 
ATOM   4137 C CB  . LEU C 1 57  ? 140.240 78.613  134.529 1.00 127.07 ? 128 LEU E CB  1 
ATOM   4138 C CG  . LEU C 1 57  ? 141.192 79.474  135.367 1.00 127.07 ? 128 LEU E CG  1 
ATOM   4139 C CD1 . LEU C 1 57  ? 142.030 80.373  134.469 1.00 127.07 ? 128 LEU E CD1 1 
ATOM   4140 C CD2 . LEU C 1 57  ? 140.445 80.291  136.413 1.00 127.07 ? 128 LEU E CD2 1 
ATOM   4141 N N   . ASN C 1 58  ? 139.630 78.561  131.293 1.00 132.33 ? 129 ASN E N   1 
ATOM   4142 C CA  . ASN C 1 58  ? 139.493 77.757  130.081 1.00 132.33 ? 129 ASN E CA  1 
ATOM   4143 C C   . ASN C 1 58  ? 138.118 77.880  129.432 1.00 132.33 ? 129 ASN E C   1 
ATOM   4144 O O   . ASN C 1 58  ? 137.845 77.196  128.438 1.00 132.33 ? 129 ASN E O   1 
ATOM   4145 C CB  . ASN C 1 58  ? 139.811 76.279  130.346 1.00 132.33 ? 129 ASN E CB  1 
ATOM   4146 C CG  . ASN C 1 58  ? 141.243 76.063  130.796 1.00 132.33 ? 129 ASN E CG  1 
ATOM   4147 O OD1 . ASN C 1 58  ? 142.142 76.818  130.426 1.00 132.33 ? 129 ASN E OD1 1 
ATOM   4148 N ND2 . ASN C 1 58  ? 141.461 75.028  131.598 1.00 132.33 ? 129 ASN E ND2 1 
ATOM   4149 N N   . ASP C 1 59  ? 137.243 78.734  129.963 1.00 128.84 ? 130 ASP E N   1 
ATOM   4150 C CA  . ASP C 1 59  ? 135.924 78.993  129.386 1.00 128.84 ? 130 ASP E CA  1 
ATOM   4151 C C   . ASP C 1 59  ? 135.762 80.507  129.300 1.00 128.84 ? 130 ASP E C   1 
ATOM   4152 O O   . ASP C 1 59  ? 135.197 81.133  130.201 1.00 128.84 ? 130 ASP E O   1 
ATOM   4153 C CB  . ASP C 1 59  ? 134.819 78.346  130.217 1.00 128.84 ? 130 ASP E CB  1 
ATOM   4154 C CG  . ASP C 1 59  ? 133.437 78.598  129.647 1.00 128.84 ? 130 ASP E CG  1 
ATOM   4155 O OD1 . ASP C 1 59  ? 133.121 78.033  128.578 1.00 128.84 ? 130 ASP E OD1 1 
ATOM   4156 O OD2 . ASP C 1 59  ? 132.666 79.359  130.268 1.00 128.84 ? 130 ASP E OD2 1 
ATOM   4157 N N   . VAL C 1 60  ? 136.261 81.095  128.213 1.00 119.69 ? 131 VAL E N   1 
ATOM   4158 C CA  . VAL C 1 60  ? 136.206 82.536  128.008 1.00 119.69 ? 131 VAL E CA  1 
ATOM   4159 C C   . VAL C 1 60  ? 135.741 82.817  126.588 1.00 119.69 ? 131 VAL E C   1 
ATOM   4160 O O   . VAL C 1 60  ? 135.919 82.000  125.680 1.00 119.69 ? 131 VAL E O   1 
ATOM   4161 C CB  . VAL C 1 60  ? 137.571 83.213  128.271 1.00 119.69 ? 131 VAL E CB  1 
ATOM   4162 C CG1 . VAL C 1 60  ? 137.969 83.070  129.730 1.00 119.69 ? 131 VAL E CG1 1 
ATOM   4163 C CG2 . VAL C 1 60  ? 138.640 82.625  127.362 1.00 119.69 ? 131 VAL E CG2 1 
ATOM   4164 N N   . SER C 1 61  ? 135.139 83.990  126.403 1.00 110.54 ? 132 SER E N   1 
ATOM   4165 C CA  . SER C 1 61  ? 134.704 84.435  125.081 1.00 110.54 ? 132 SER E CA  1 
ATOM   4166 C C   . SER C 1 61  ? 134.465 85.933  125.143 1.00 110.54 ? 132 SER E C   1 
ATOM   4167 O O   . SER C 1 61  ? 133.637 86.395  125.936 1.00 110.54 ? 132 SER E O   1 
ATOM   4168 C CB  . SER C 1 61  ? 133.437 83.701  124.641 1.00 110.54 ? 132 SER E CB  1 
ATOM   4169 O OG  . SER C 1 61  ? 132.373 83.939  125.543 1.00 110.54 ? 132 SER E OG  1 
ATOM   4170 N N   . VAL C 1 62  ? 135.181 86.688  124.315 1.00 103.19 ? 133 VAL E N   1 
ATOM   4171 C CA  . VAL C 1 62  ? 135.049 88.137  124.244 1.00 103.19 ? 133 VAL E CA  1 
ATOM   4172 C C   . VAL C 1 62  ? 134.622 88.508  122.832 1.00 103.19 ? 133 VAL E C   1 
ATOM   4173 O O   . VAL C 1 62  ? 135.229 88.056  121.854 1.00 103.19 ? 133 VAL E O   1 
ATOM   4174 C CB  . VAL C 1 62  ? 136.358 88.850  124.636 1.00 103.19 ? 133 VAL E CB  1 
ATOM   4175 C CG1 . VAL C 1 62  ? 136.548 88.807  126.142 1.00 103.19 ? 133 VAL E CG1 1 
ATOM   4176 C CG2 . VAL C 1 62  ? 137.549 88.210  123.937 1.00 103.19 ? 133 VAL E CG2 1 
ATOM   4177 N N   . SER C 1 63  ? 133.569 89.316  122.726 1.00 100.13 ? 134 SER E N   1 
ATOM   4178 C CA  . SER C 1 63  ? 133.043 89.739  121.435 1.00 100.13 ? 134 SER E CA  1 
ATOM   4179 C C   . SER C 1 63  ? 132.996 91.257  121.382 1.00 100.13 ? 134 SER E C   1 
ATOM   4180 O O   . SER C 1 63  ? 132.498 91.900  122.311 1.00 100.13 ? 134 SER E O   1 
ATOM   4181 C CB  . SER C 1 63  ? 131.648 89.156  121.188 1.00 100.13 ? 134 SER E CB  1 
ATOM   4182 O OG  . SER C 1 63  ? 131.675 87.739  121.210 1.00 100.13 ? 134 SER E OG  1 
ATOM   4183 N N   . TRP C 1 64  ? 133.514 91.824  120.297 1.00 95.37  ? 135 TRP E N   1 
ATOM   4184 C CA  . TRP C 1 64  ? 133.472 93.260  120.052 1.00 95.37  ? 135 TRP E CA  1 
ATOM   4185 C C   . TRP C 1 64  ? 132.416 93.534  118.991 1.00 95.37  ? 135 TRP E C   1 
ATOM   4186 O O   . TRP C 1 64  ? 132.520 93.037  117.864 1.00 95.37  ? 135 TRP E O   1 
ATOM   4187 C CB  . TRP C 1 64  ? 134.838 93.782  119.606 1.00 95.37  ? 135 TRP E CB  1 
ATOM   4188 C CG  . TRP C 1 64  ? 135.901 93.649  120.651 1.00 95.37  ? 135 TRP E CG  1 
ATOM   4189 C CD1 . TRP C 1 64  ? 136.705 92.568  120.870 1.00 95.37  ? 135 TRP E CD1 1 
ATOM   4190 C CD2 . TRP C 1 64  ? 136.279 94.634  121.619 1.00 95.37  ? 135 TRP E CD2 1 
ATOM   4191 N NE1 . TRP C 1 64  ? 137.560 92.819  121.917 1.00 95.37  ? 135 TRP E NE1 1 
ATOM   4192 C CE2 . TRP C 1 64  ? 137.318 94.081  122.394 1.00 95.37  ? 135 TRP E CE2 1 
ATOM   4193 C CE3 . TRP C 1 64  ? 135.840 95.929  121.907 1.00 95.37  ? 135 TRP E CE3 1 
ATOM   4194 C CZ2 . TRP C 1 64  ? 137.924 94.778  123.436 1.00 95.37  ? 135 TRP E CZ2 1 
ATOM   4195 C CZ3 . TRP C 1 64  ? 136.442 96.619  122.942 1.00 95.37  ? 135 TRP E CZ3 1 
ATOM   4196 C CH2 . TRP C 1 64  ? 137.473 96.043  123.694 1.00 95.37  ? 135 TRP E CH2 1 
ATOM   4197 N N   . LEU C 1 65  ? 131.406 94.321  119.351 1.00 91.34  ? 136 LEU E N   1 
ATOM   4198 C CA  . LEU C 1 65  ? 130.283 94.614  118.471 1.00 91.34  ? 136 LEU E CA  1 
ATOM   4199 C C   . LEU C 1 65  ? 130.258 96.103  118.160 1.00 91.34  ? 136 LEU E C   1 
ATOM   4200 O O   . LEU C 1 65  ? 130.340 96.934  119.070 1.00 91.34  ? 136 LEU E O   1 
ATOM   4201 C CB  . LEU C 1 65  ? 128.952 94.186  119.101 1.00 91.34  ? 136 LEU E CB  1 
ATOM   4202 C CG  . LEU C 1 65  ? 128.615 92.692  119.142 1.00 91.34  ? 136 LEU E CG  1 
ATOM   4203 C CD1 . LEU C 1 65  ? 129.396 91.965  120.229 1.00 91.34  ? 136 LEU E CD1 1 
ATOM   4204 C CD2 . LEU C 1 65  ? 127.118 92.486  119.326 1.00 91.34  ? 136 LEU E CD2 1 
ATOM   4205 N N   . MET C 1 66  ? 130.147 96.433  116.877 1.00 86.49  ? 137 MET E N   1 
ATOM   4206 C CA  . MET C 1 66  ? 130.005 97.812  116.419 1.00 86.49  ? 137 MET E CA  1 
ATOM   4207 C C   . MET C 1 66  ? 128.599 97.954  115.845 1.00 86.49  ? 137 MET E C   1 
ATOM   4208 O O   . MET C 1 66  ? 128.318 97.469  114.745 1.00 86.49  ? 137 MET E O   1 
ATOM   4209 C CB  . MET C 1 66  ? 131.076 98.164  115.390 1.00 86.49  ? 137 MET E CB  1 
ATOM   4210 C CG  . MET C 1 66  ? 131.027 99.607  114.916 1.00 86.49  ? 137 MET E CG  1 
ATOM   4211 S SD  . MET C 1 66  ? 132.357 100.013 113.769 1.00 86.49  ? 137 MET E SD  1 
ATOM   4212 C CE  . MET C 1 66  ? 131.992 98.899  112.416 1.00 86.49  ? 137 MET E CE  1 
ATOM   4213 N N   . ASP C 1 67  ? 127.722 98.621  116.598 1.00 89.88  ? 138 ASP E N   1 
ATOM   4214 C CA  . ASP C 1 67  ? 126.313 98.774  116.233 1.00 89.88  ? 138 ASP E CA  1 
ATOM   4215 C C   . ASP C 1 67  ? 125.654 97.412  116.016 1.00 89.88  ? 138 ASP E C   1 
ATOM   4216 O O   . ASP C 1 67  ? 125.027 97.153  114.986 1.00 89.88  ? 138 ASP E O   1 
ATOM   4217 C CB  . ASP C 1 67  ? 126.155 99.668  115.000 1.00 89.88  ? 138 ASP E CB  1 
ATOM   4218 C CG  . ASP C 1 67  ? 126.662 101.077 115.233 1.00 89.88  ? 138 ASP E CG  1 
ATOM   4219 O OD1 . ASP C 1 67  ? 126.618 101.542 116.392 1.00 89.88  ? 138 ASP E OD1 1 
ATOM   4220 O OD2 . ASP C 1 67  ? 127.102 101.721 114.258 1.00 89.88  ? 138 ASP E OD2 1 
ATOM   4221 N N   . ASP C 1 68  ? 125.806 96.535  117.012 1.00 89.03  ? 139 ASP E N   1 
ATOM   4222 C CA  . ASP C 1 68  ? 125.234 95.186  116.989 1.00 89.03  ? 139 ASP E CA  1 
ATOM   4223 C C   . ASP C 1 68  ? 125.706 94.394  115.770 1.00 89.03  ? 139 ASP E C   1 
ATOM   4224 O O   . ASP C 1 68  ? 124.941 93.647  115.158 1.00 89.03  ? 139 ASP E O   1 
ATOM   4225 C CB  . ASP C 1 68  ? 123.705 95.233  117.049 1.00 89.03  ? 139 ASP E CB  1 
ATOM   4226 C CG  . ASP C 1 68  ? 123.191 95.858  118.331 1.00 89.03  ? 139 ASP E CG  1 
ATOM   4227 O OD1 . ASP C 1 68  ? 123.877 95.740  119.367 1.00 89.03  ? 139 ASP E OD1 1 
ATOM   4228 O OD2 . ASP C 1 68  ? 122.101 96.466  118.302 1.00 89.03  ? 139 ASP E OD2 1 
ATOM   4229 N N   . ARG C 1 69  ? 126.979 94.559  115.415 1.00 92.44  ? 140 ARG E N   1 
ATOM   4230 C CA  . ARG C 1 69  ? 127.592 93.814  114.323 1.00 92.44  ? 140 ARG E CA  1 
ATOM   4231 C C   . ARG C 1 69  ? 128.973 93.350  114.759 1.00 92.44  ? 140 ARG E C   1 
ATOM   4232 O O   . ARG C 1 69  ? 129.737 94.128  115.338 1.00 92.44  ? 140 ARG E O   1 
ATOM   4233 C CB  . ARG C 1 69  ? 127.694 94.665  113.053 1.00 92.44  ? 140 ARG E CB  1 
ATOM   4234 C CG  . ARG C 1 69  ? 128.086 93.875  111.814 1.00 92.44  ? 140 ARG E CG  1 
ATOM   4235 C CD  . ARG C 1 69  ? 128.262 94.781  110.606 1.00 92.44  ? 140 ARG E CD  1 
ATOM   4236 N NE  . ARG C 1 69  ? 129.434 95.639  110.733 1.00 92.44  ? 140 ARG E NE  1 
ATOM   4237 C CZ  . ARG C 1 69  ? 130.650 95.309  110.318 1.00 92.44  ? 140 ARG E CZ  1 
ATOM   4238 N NH1 . ARG C 1 69  ? 130.891 94.142  109.743 1.00 92.44  ? 140 ARG E NH1 1 
ATOM   4239 N NH2 . ARG C 1 69  ? 131.648 96.172  110.483 1.00 92.44  ? 140 ARG E NH2 1 
ATOM   4240 N N   . GLU C 1 70  ? 129.288 92.088  114.479 1.00 96.12  ? 141 GLU E N   1 
ATOM   4241 C CA  . GLU C 1 70  ? 130.575 91.531  114.875 1.00 96.12  ? 141 GLU E CA  1 
ATOM   4242 C C   . GLU C 1 70  ? 131.713 92.221  114.134 1.00 96.12  ? 141 GLU E C   1 
ATOM   4243 O O   . GLU C 1 70  ? 131.593 92.567  112.956 1.00 96.12  ? 141 GLU E O   1 
ATOM   4244 C CB  . GLU C 1 70  ? 130.610 90.025  114.608 1.00 96.12  ? 141 GLU E CB  1 
ATOM   4245 C CG  . GLU C 1 70  ? 129.786 89.189  115.581 1.00 96.12  ? 141 GLU E CG  1 
ATOM   4246 C CD  . GLU C 1 70  ? 128.291 89.314  115.355 1.00 96.12  ? 141 GLU E CD  1 
ATOM   4247 O OE1 . GLU C 1 70  ? 127.887 89.807  114.280 1.00 96.12  ? 141 GLU E OE1 1 
ATOM   4248 O OE2 . GLU C 1 70  ? 127.518 88.920  116.253 1.00 96.12  ? 141 GLU E OE2 1 
ATOM   4249 N N   . ILE C 1 71  ? 132.829 92.421  114.839 1.00 100.46 ? 142 ILE E N   1 
ATOM   4250 C CA  . ILE C 1 71  ? 133.978 93.093  114.248 1.00 100.46 ? 142 ILE E CA  1 
ATOM   4251 C C   . ILE C 1 71  ? 134.656 92.166  113.244 1.00 100.46 ? 142 ILE E C   1 
ATOM   4252 O O   . ILE C 1 71  ? 134.591 90.933  113.351 1.00 100.46 ? 142 ILE E O   1 
ATOM   4253 C CB  . ILE C 1 71  ? 134.956 93.551  115.346 1.00 100.46 ? 142 ILE E CB  1 
ATOM   4254 C CG1 . ILE C 1 71  ? 135.979 94.544  114.788 1.00 100.46 ? 142 ILE E CG1 1 
ATOM   4255 C CG2 . ILE C 1 71  ? 135.655 92.356  115.982 1.00 100.46 ? 142 ILE E CG2 1 
ATOM   4256 C CD1 . ILE C 1 71  ? 135.360 95.805  114.223 1.00 100.46 ? 142 ILE E CD1 1 
ATOM   4257 N N   . THR C 1 72  ? 135.304 92.765  112.246 1.00 109.51 ? 143 THR E N   1 
ATOM   4258 C CA  . THR C 1 72  ? 135.991 92.024  111.194 1.00 109.51 ? 143 THR E CA  1 
ATOM   4259 C C   . THR C 1 72  ? 137.495 91.940  111.413 1.00 109.51 ? 143 THR E C   1 
ATOM   4260 O O   . THR C 1 72  ? 138.104 90.910  111.104 1.00 109.51 ? 143 THR E O   1 
ATOM   4261 C CB  . THR C 1 72  ? 135.710 92.665  109.830 1.00 109.51 ? 143 THR E CB  1 
ATOM   4262 O OG1 . THR C 1 72  ? 134.296 92.829  109.660 1.00 109.51 ? 143 THR E OG1 1 
ATOM   4263 C CG2 . THR C 1 72  ? 136.246 91.793  108.703 1.00 109.51 ? 143 THR E CG2 1 
ATOM   4264 N N   . ASP C 1 73  ? 138.108 92.995  111.945 1.00 110.62 ? 144 ASP E N   1 
ATOM   4265 C CA  . ASP C 1 73  ? 139.548 93.001  112.157 1.00 110.62 ? 144 ASP E CA  1 
ATOM   4266 C C   . ASP C 1 73  ? 139.944 91.969  113.206 1.00 110.62 ? 144 ASP E C   1 
ATOM   4267 O O   . ASP C 1 73  ? 139.255 91.783  114.213 1.00 110.62 ? 144 ASP E O   1 
ATOM   4268 C CB  . ASP C 1 73  ? 140.016 94.391  112.586 1.00 110.62 ? 144 ASP E CB  1 
ATOM   4269 C CG  . ASP C 1 73  ? 139.696 95.457  111.556 1.00 110.62 ? 144 ASP E CG  1 
ATOM   4270 O OD1 . ASP C 1 73  ? 139.655 95.128  110.352 1.00 110.62 ? 144 ASP E OD1 1 
ATOM   4271 O OD2 . ASP C 1 73  ? 139.485 96.623  111.951 1.00 110.62 ? 144 ASP E OD2 1 
ATOM   4272 N N   . THR C 1 74  ? 141.066 91.294  112.963 1.00 111.19 ? 145 THR E N   1 
ATOM   4273 C CA  . THR C 1 74  ? 141.569 90.257  113.852 1.00 111.19 ? 145 THR E CA  1 
ATOM   4274 C C   . THR C 1 74  ? 142.623 90.766  114.826 1.00 111.19 ? 145 THR E C   1 
ATOM   4275 O O   . THR C 1 74  ? 143.197 89.964  115.569 1.00 111.19 ? 145 THR E O   1 
ATOM   4276 C CB  . THR C 1 74  ? 142.148 89.095  113.036 1.00 111.19 ? 145 THR E CB  1 
ATOM   4277 O OG1 . THR C 1 74  ? 143.224 89.571  112.218 1.00 111.19 ? 145 THR E OG1 1 
ATOM   4278 C CG2 . THR C 1 74  ? 141.075 88.482  112.149 1.00 111.19 ? 145 THR E CG2 1 
ATOM   4279 N N   . LEU C 1 75  ? 142.890 92.073  114.845 1.00 107.22 ? 146 LEU E N   1 
ATOM   4280 C CA  . LEU C 1 75  ? 143.896 92.648  115.737 1.00 107.22 ? 146 LEU E CA  1 
ATOM   4281 C C   . LEU C 1 75  ? 143.308 92.876  117.132 1.00 107.22 ? 146 LEU E C   1 
ATOM   4282 O O   . LEU C 1 75  ? 143.194 93.998  117.626 1.00 107.22 ? 146 LEU E O   1 
ATOM   4283 C CB  . LEU C 1 75  ? 144.445 93.941  115.147 1.00 107.22 ? 146 LEU E CB  1 
ATOM   4284 C CG  . LEU C 1 75  ? 145.203 93.815  113.824 1.00 107.22 ? 146 LEU E CG  1 
ATOM   4285 C CD1 . LEU C 1 75  ? 145.683 95.177  113.348 1.00 107.22 ? 146 LEU E CD1 1 
ATOM   4286 C CD2 . LEU C 1 75  ? 146.370 92.850  113.964 1.00 107.22 ? 146 LEU E CD2 1 
ATOM   4287 N N   . ALA C 1 76  ? 142.931 91.771  117.768 1.00 106.28 ? 147 ALA E N   1 
ATOM   4288 C CA  . ALA C 1 76  ? 142.367 91.773  119.116 1.00 106.28 ? 147 ALA E CA  1 
ATOM   4289 C C   . ALA C 1 76  ? 143.360 91.065  120.034 1.00 106.28 ? 147 ALA E C   1 
ATOM   4290 O O   . ALA C 1 76  ? 143.294 89.850  120.229 1.00 106.28 ? 147 ALA E O   1 
ATOM   4291 C CB  . ALA C 1 76  ? 140.997 91.101  119.141 1.00 106.28 ? 147 ALA E CB  1 
ATOM   4292 N N   . GLN C 1 77  ? 144.285 91.837  120.600 1.00 107.21 ? 148 GLN E N   1 
ATOM   4293 C CA  . GLN C 1 77  ? 145.309 91.285  121.481 1.00 107.21 ? 148 GLN E CA  1 
ATOM   4294 C C   . GLN C 1 77  ? 144.696 90.972  122.840 1.00 107.21 ? 148 GLN E C   1 
ATOM   4295 O O   . GLN C 1 77  ? 144.355 91.882  123.602 1.00 107.21 ? 148 GLN E O   1 
ATOM   4296 C CB  . GLN C 1 77  ? 146.471 92.265  121.618 1.00 107.21 ? 148 GLN E CB  1 
ATOM   4297 C CG  . GLN C 1 77  ? 147.158 92.600  120.304 1.00 107.21 ? 148 GLN E CG  1 
ATOM   4298 C CD  . GLN C 1 77  ? 148.308 93.573  120.480 1.00 107.21 ? 148 GLN E CD  1 
ATOM   4299 O OE1 . GLN C 1 77  ? 148.604 94.007  121.593 1.00 107.21 ? 148 GLN E OE1 1 
ATOM   4300 N NE2 . GLN C 1 77  ? 148.963 93.921  119.378 1.00 107.21 ? 148 GLN E NE2 1 
ATOM   4301 N N   . THR C 1 78  ? 144.555 89.685  123.145 1.00 108.70 ? 149 THR E N   1 
ATOM   4302 C CA  . THR C 1 78  ? 143.994 89.225  124.410 1.00 108.70 ? 149 THR E CA  1 
ATOM   4303 C C   . THR C 1 78  ? 145.085 88.517  125.202 1.00 108.70 ? 149 THR E C   1 
ATOM   4304 O O   . THR C 1 78  ? 145.699 87.567  124.705 1.00 108.70 ? 149 THR E O   1 
ATOM   4305 C CB  . THR C 1 78  ? 142.806 88.291  124.175 1.00 108.70 ? 149 THR E CB  1 
ATOM   4306 O OG1 . THR C 1 78  ? 141.791 88.982  123.436 1.00 108.70 ? 149 THR E OG1 1 
ATOM   4307 C CG2 . THR C 1 78  ? 142.228 87.820  125.499 1.00 108.70 ? 149 THR E CG2 1 
ATOM   4308 N N   . VAL C 1 79  ? 145.322 88.979  126.427 1.00 109.81 ? 150 VAL E N   1 
ATOM   4309 C CA  . VAL C 1 79  ? 146.341 88.405  127.299 1.00 109.81 ? 150 VAL E CA  1 
ATOM   4310 C C   . VAL C 1 79  ? 145.793 88.351  128.720 1.00 109.81 ? 150 VAL E C   1 
ATOM   4311 O O   . VAL C 1 79  ? 145.128 89.287  129.178 1.00 109.81 ? 150 VAL E O   1 
ATOM   4312 C CB  . VAL C 1 79  ? 147.661 89.205  127.232 1.00 109.81 ? 150 VAL E CB  1 
ATOM   4313 C CG1 . VAL C 1 79  ? 147.422 90.676  127.547 1.00 109.81 ? 150 VAL E CG1 1 
ATOM   4314 C CG2 . VAL C 1 79  ? 148.705 88.610  128.169 1.00 109.81 ? 150 VAL E CG2 1 
ATOM   4315 N N   . LEU C 1 80  ? 146.062 87.245  129.410 1.00 110.57 ? 151 LEU E N   1 
ATOM   4316 C CA  . LEU C 1 80  ? 145.603 87.066  130.782 1.00 110.57 ? 151 LEU E CA  1 
ATOM   4317 C C   . LEU C 1 80  ? 146.309 88.055  131.702 1.00 110.57 ? 151 LEU E C   1 
ATOM   4318 O O   . LEU C 1 80  ? 147.542 88.059  131.789 1.00 110.57 ? 151 LEU E O   1 
ATOM   4319 C CB  . LEU C 1 80  ? 145.865 85.631  131.234 1.00 110.57 ? 151 LEU E CB  1 
ATOM   4320 C CG  . LEU C 1 80  ? 145.554 85.266  132.688 1.00 110.57 ? 151 LEU E CG  1 
ATOM   4321 C CD1 . LEU C 1 80  ? 144.057 85.131  132.907 1.00 110.57 ? 151 LEU E CD1 1 
ATOM   4322 C CD2 . LEU C 1 80  ? 146.274 83.986  133.085 1.00 110.57 ? 151 LEU E CD2 1 
ATOM   4323 N N   . ILE C 1 81  ? 145.531 88.898  132.385 1.00 107.95 ? 152 ILE E N   1 
ATOM   4324 C CA  . ILE C 1 81  ? 146.119 89.840  133.333 1.00 107.95 ? 152 ILE E CA  1 
ATOM   4325 C C   . ILE C 1 81  ? 146.716 89.096  134.520 1.00 107.95 ? 152 ILE E C   1 
ATOM   4326 O O   . ILE C 1 81  ? 147.870 89.323  134.900 1.00 107.95 ? 152 ILE E O   1 
ATOM   4327 C CB  . ILE C 1 81  ? 145.074 90.871  133.795 1.00 107.95 ? 152 ILE E CB  1 
ATOM   4328 C CG1 . ILE C 1 81  ? 144.458 91.601  132.602 1.00 107.95 ? 152 ILE E CG1 1 
ATOM   4329 C CG2 . ILE C 1 81  ? 145.698 91.865  134.762 1.00 107.95 ? 152 ILE E CG2 1 
ATOM   4330 C CD1 . ILE C 1 81  ? 143.377 92.580  133.002 1.00 107.95 ? 152 ILE E CD1 1 
ATOM   4331 N N   . LYS C 1 82  ? 145.943 88.190  135.114 1.00 108.47 ? 153 LYS E N   1 
ATOM   4332 C CA  . LYS C 1 82  ? 146.381 87.490  136.317 1.00 108.47 ? 153 LYS E CA  1 
ATOM   4333 C C   . LYS C 1 82  ? 145.457 86.308  136.575 1.00 108.47 ? 153 LYS E C   1 
ATOM   4334 O O   . LYS C 1 82  ? 144.374 86.199  135.995 1.00 108.47 ? 153 LYS E O   1 
ATOM   4335 C CB  . LYS C 1 82  ? 146.418 88.426  137.530 1.00 108.47 ? 153 LYS E CB  1 
ATOM   4336 C CG  . LYS C 1 82  ? 145.145 89.229  137.738 1.00 108.47 ? 153 LYS E CG  1 
ATOM   4337 C CD  . LYS C 1 82  ? 145.270 90.159  138.934 1.00 108.47 ? 153 LYS E CD  1 
ATOM   4338 C CE  . LYS C 1 82  ? 144.045 91.048  139.076 1.00 108.47 ? 153 LYS E CE  1 
ATOM   4339 N NZ  . LYS C 1 82  ? 144.151 91.957  140.251 1.00 108.47 ? 153 LYS E NZ  1 
ATOM   4340 N N   . GLU C 1 83  ? 145.899 85.427  137.471 1.00 113.81 ? 154 GLU E N   1 
ATOM   4341 C CA  . GLU C 1 83  ? 145.161 84.226  137.834 1.00 113.81 ? 154 GLU E CA  1 
ATOM   4342 C C   . GLU C 1 83  ? 144.959 84.197  139.342 1.00 113.81 ? 154 GLU E C   1 
ATOM   4343 O O   . GLU C 1 83  ? 145.911 84.399  140.103 1.00 113.81 ? 154 GLU E O   1 
ATOM   4344 C CB  . GLU C 1 83  ? 145.899 82.966  137.364 1.00 113.81 ? 154 GLU E CB  1 
ATOM   4345 C CG  . GLU C 1 83  ? 145.171 81.661  137.645 1.00 113.81 ? 154 GLU E CG  1 
ATOM   4346 C CD  . GLU C 1 83  ? 145.711 80.942  138.866 1.00 113.81 ? 154 GLU E CD  1 
ATOM   4347 O OE1 . GLU C 1 83  ? 146.511 81.546  139.610 1.00 113.81 ? 154 GLU E OE1 1 
ATOM   4348 O OE2 . GLU C 1 83  ? 145.339 79.769  139.077 1.00 113.81 ? 154 GLU E OE2 1 
ATOM   4349 N N   . GLU C 1 84  ? 143.720 83.949  139.767 1.00 111.88 ? 155 GLU E N   1 
ATOM   4350 C CA  . GLU C 1 84  ? 143.339 83.891  141.171 1.00 111.88 ? 155 GLU E CA  1 
ATOM   4351 C C   . GLU C 1 84  ? 142.779 82.508  141.478 1.00 111.88 ? 155 GLU E C   1 
ATOM   4352 O O   . GLU C 1 84  ? 141.656 82.382  141.981 1.00 111.88 ? 155 GLU E O   1 
ATOM   4353 C CB  . GLU C 1 84  ? 142.311 84.974  141.510 1.00 111.88 ? 155 GLU E CB  1 
ATOM   4354 C CG  . GLU C 1 84  ? 142.806 86.403  141.338 1.00 111.88 ? 155 GLU E CG  1 
ATOM   4355 C CD  . GLU C 1 84  ? 142.668 86.909  139.915 1.00 111.88 ? 155 GLU E CD  1 
ATOM   4356 O OE1 . GLU C 1 84  ? 142.452 86.085  139.003 1.00 111.88 ? 155 GLU E OE1 1 
ATOM   4357 O OE2 . GLU C 1 84  ? 142.769 88.136  139.710 1.00 111.88 ? 155 GLU E OE2 1 
ATOM   4358 N N   . GLY C 1 85  ? 143.514 81.467  141.094 1.00 112.74 ? 156 GLY E N   1 
ATOM   4359 C CA  . GLY C 1 85  ? 143.086 80.110  141.365 1.00 112.74 ? 156 GLY E CA  1 
ATOM   4360 C C   . GLY C 1 85  ? 141.860 79.743  140.560 1.00 112.74 ? 156 GLY E C   1 
ATOM   4361 O O   . GLY C 1 85  ? 141.941 79.530  139.347 1.00 112.74 ? 156 GLY E O   1 
ATOM   4362 N N   . LYS C 1 86  ? 140.712 79.665  141.233 1.00 112.90 ? 157 LYS E N   1 
ATOM   4363 C CA  . LYS C 1 86  ? 139.453 79.436  140.538 1.00 112.90 ? 157 LYS E CA  1 
ATOM   4364 C C   . LYS C 1 86  ? 139.008 80.641  139.720 1.00 112.90 ? 157 LYS E C   1 
ATOM   4365 O O   . LYS C 1 86  ? 138.059 80.515  138.938 1.00 112.90 ? 157 LYS E O   1 
ATOM   4366 C CB  . LYS C 1 86  ? 138.355 79.058  141.535 1.00 112.90 ? 157 LYS E CB  1 
ATOM   4367 C CG  . LYS C 1 86  ? 138.306 77.577  141.900 1.00 112.90 ? 157 LYS E CG  1 
ATOM   4368 C CD  . LYS C 1 86  ? 139.472 77.165  142.787 1.00 112.90 ? 157 LYS E CD  1 
ATOM   4369 C CE  . LYS C 1 86  ? 139.471 77.940  144.094 1.00 112.90 ? 157 LYS E CE  1 
ATOM   4370 N NZ  . LYS C 1 86  ? 140.604 77.543  144.975 1.00 112.90 ? 157 LYS E NZ  1 
ATOM   4371 N N   . LEU C 1 87  ? 139.656 81.793  139.872 1.00 113.13 ? 158 LEU E N   1 
ATOM   4372 C CA  . LEU C 1 87  ? 139.287 82.987  139.126 1.00 113.13 ? 158 LEU E CA  1 
ATOM   4373 C C   . LEU C 1 87  ? 140.406 83.393  138.173 1.00 113.13 ? 158 LEU E C   1 
ATOM   4374 O O   . LEU C 1 87  ? 141.534 82.903  138.246 1.00 113.13 ? 158 LEU E O   1 
ATOM   4375 C CB  . LEU C 1 87  ? 138.952 84.141  140.080 1.00 113.13 ? 158 LEU E CB  1 
ATOM   4376 C CG  . LEU C 1 87  ? 137.755 83.917  141.006 1.00 113.13 ? 158 LEU E CG  1 
ATOM   4377 C CD1 . LEU C 1 87  ? 137.504 85.145  141.867 1.00 113.13 ? 158 LEU E CD1 1 
ATOM   4378 C CD2 . LEU C 1 87  ? 136.514 83.556  140.204 1.00 113.13 ? 158 LEU E CD2 1 
ATOM   4379 N N   . ALA C 1 88  ? 140.082 84.318  137.274 1.00 110.15 ? 159 ALA E N   1 
ATOM   4380 C CA  . ALA C 1 88  ? 141.069 84.845  136.345 1.00 110.15 ? 159 ALA E CA  1 
ATOM   4381 C C   . ALA C 1 88  ? 140.649 86.237  135.901 1.00 110.15 ? 159 ALA E C   1 
ATOM   4382 O O   . ALA C 1 88  ? 139.458 86.554  135.845 1.00 110.15 ? 159 ALA E O   1 
ATOM   4383 C CB  . ALA C 1 88  ? 141.247 83.928  135.129 1.00 110.15 ? 159 ALA E CB  1 
ATOM   4384 N N   . SER C 1 89  ? 141.642 87.066  135.589 1.00 108.94 ? 160 SER E N   1 
ATOM   4385 C CA  . SER C 1 89  ? 141.427 88.406  135.064 1.00 108.94 ? 160 SER E CA  1 
ATOM   4386 C C   . SER C 1 89  ? 142.179 88.533  133.748 1.00 108.94 ? 160 SER E C   1 
ATOM   4387 O O   . SER C 1 89  ? 143.374 88.223  133.683 1.00 108.94 ? 160 SER E O   1 
ATOM   4388 C CB  . SER C 1 89  ? 141.894 89.474  136.055 1.00 108.94 ? 160 SER E CB  1 
ATOM   4389 O OG  . SER C 1 89  ? 141.197 89.370  137.284 1.00 108.94 ? 160 SER E OG  1 
ATOM   4390 N N   . THR C 1 90  ? 141.475 88.991  132.713 1.00 106.60 ? 161 THR E N   1 
ATOM   4391 C CA  . THR C 1 90  ? 142.004 89.052  131.357 1.00 106.60 ? 161 THR E CA  1 
ATOM   4392 C C   . THR C 1 90  ? 141.579 90.354  130.692 1.00 106.60 ? 161 THR E C   1 
ATOM   4393 O O   . THR C 1 90  ? 140.445 90.810  130.868 1.00 106.60 ? 161 THR E O   1 
ATOM   4394 C CB  . THR C 1 90  ? 141.520 87.858  130.518 1.00 106.60 ? 161 THR E CB  1 
ATOM   4395 O OG1 . THR C 1 90  ? 141.805 86.638  131.211 1.00 106.60 ? 161 THR E OG1 1 
ATOM   4396 C CG2 . THR C 1 90  ? 142.211 87.830  129.165 1.00 106.60 ? 161 THR E CG2 1 
ATOM   4397 N N   . CYS C 1 91  ? 142.487 90.941  129.916 1.00 105.45 ? 162 CYS E N   1 
ATOM   4398 C CA  . CYS C 1 91  ? 142.221 92.170  129.180 1.00 105.45 ? 162 CYS E CA  1 
ATOM   4399 C C   . CYS C 1 91  ? 142.228 91.889  127.684 1.00 105.45 ? 162 CYS E C   1 
ATOM   4400 O O   . CYS C 1 91  ? 143.130 91.214  127.177 1.00 105.45 ? 162 CYS E O   1 
ATOM   4401 C CB  . CYS C 1 91  ? 143.253 93.250  129.516 1.00 105.45 ? 162 CYS E CB  1 
ATOM   4402 S SG  . CYS C 1 91  ? 144.973 92.783  129.208 1.00 105.45 ? 162 CYS E SG  1 
ATOM   4403 N N   . SER C 1 92  ? 141.219 92.403  126.986 1.00 97.78  ? 163 SER E N   1 
ATOM   4404 C CA  . SER C 1 92  ? 141.146 92.352  125.533 1.00 97.78  ? 163 SER E CA  1 
ATOM   4405 C C   . SER C 1 92  ? 141.443 93.739  124.979 1.00 97.78  ? 163 SER E C   1 
ATOM   4406 O O   . SER C 1 92  ? 140.810 94.720  125.384 1.00 97.78  ? 163 SER E O   1 
ATOM   4407 C CB  . SER C 1 92  ? 139.769 91.875  125.067 1.00 97.78  ? 163 SER E CB  1 
ATOM   4408 O OG  . SER C 1 92  ? 139.690 91.845  123.653 1.00 97.78  ? 163 SER E OG  1 
ATOM   4409 N N   . LYS C 1 93  ? 142.401 93.812  124.059 1.00 94.58  ? 164 LYS E N   1 
ATOM   4410 C CA  . LYS C 1 93  ? 142.881 95.070  123.501 1.00 94.58  ? 164 LYS E CA  1 
ATOM   4411 C C   . LYS C 1 93  ? 142.518 95.150  122.025 1.00 94.58  ? 164 LYS E C   1 
ATOM   4412 O O   . LYS C 1 93  ? 142.759 94.202  121.270 1.00 94.58  ? 164 LYS E O   1 
ATOM   4413 C CB  . LYS C 1 93  ? 144.396 95.197  123.681 1.00 94.58  ? 164 LYS E CB  1 
ATOM   4414 C CG  . LYS C 1 93  ? 145.015 96.404  122.996 1.00 94.58  ? 164 LYS E CG  1 
ATOM   4415 C CD  . LYS C 1 93  ? 146.531 96.382  123.121 1.00 94.58  ? 164 LYS E CD  1 
ATOM   4416 C CE  . LYS C 1 93  ? 147.164 97.578  122.432 1.00 94.58  ? 164 LYS E CE  1 
ATOM   4417 N NZ  . LYS C 1 93  ? 146.732 98.863  123.046 1.00 94.58  ? 164 LYS E NZ  1 
ATOM   4418 N N   . LEU C 1 94  ? 141.942 96.280  121.619 1.00 87.02  ? 165 LEU E N   1 
ATOM   4419 C CA  . LEU C 1 94  ? 141.548 96.504  120.236 1.00 87.02  ? 165 LEU E CA  1 
ATOM   4420 C C   . LEU C 1 94  ? 141.983 97.895  119.797 1.00 87.02  ? 165 LEU E C   1 
ATOM   4421 O O   . LEU C 1 94  ? 142.021 98.831  120.598 1.00 87.02  ? 165 LEU E O   1 
ATOM   4422 C CB  . LEU C 1 94  ? 140.029 96.343  120.057 1.00 87.02  ? 165 LEU E CB  1 
ATOM   4423 C CG  . LEU C 1 94  ? 139.471 96.405  118.633 1.00 87.02  ? 165 LEU E CG  1 
ATOM   4424 C CD1 . LEU C 1 94  ? 140.103 95.332  117.761 1.00 87.02  ? 165 LEU E CD1 1 
ATOM   4425 C CD2 . LEU C 1 94  ? 137.957 96.268  118.646 1.00 87.02  ? 165 LEU E CD2 1 
ATOM   4426 N N   . ASN C 1 95  ? 142.314 98.023  118.514 1.00 83.67  ? 166 ASN E N   1 
ATOM   4427 C CA  . ASN C 1 95  ? 142.713 99.293  117.922 1.00 83.67  ? 166 ASN E CA  1 
ATOM   4428 C C   . ASN C 1 95  ? 141.588 99.806  117.033 1.00 83.67  ? 166 ASN E C   1 
ATOM   4429 O O   . ASN C 1 95  ? 141.073 99.064  116.190 1.00 83.67  ? 166 ASN E O   1 
ATOM   4430 C CB  . ASN C 1 95  ? 144.001 99.139  117.109 1.00 83.67  ? 166 ASN E CB  1 
ATOM   4431 C CG  . ASN C 1 95  ? 145.086 98.404  117.869 1.00 83.67  ? 166 ASN E CG  1 
ATOM   4432 O OD1 . ASN C 1 95  ? 145.059 98.330  119.097 1.00 83.67  ? 166 ASN E OD1 1 
ATOM   4433 N ND2 . ASN C 1 95  ? 146.051 97.855  117.140 1.00 83.67  ? 166 ASN E ND2 1 
ATOM   4434 N N   . ILE C 1 96  ? 141.211 101.070 117.219 1.00 77.26  ? 167 ILE E N   1 
ATOM   4435 C CA  . ILE C 1 96  ? 140.112 101.678 116.479 1.00 77.26  ? 167 ILE E CA  1 
ATOM   4436 C C   . ILE C 1 96  ? 140.614 102.950 115.810 1.00 77.26  ? 167 ILE E C   1 
ATOM   4437 O O   . ILE C 1 96  ? 141.296 103.763 116.443 1.00 77.26  ? 167 ILE E O   1 
ATOM   4438 C CB  . ILE C 1 96  ? 138.910 101.987 117.394 1.00 77.26  ? 167 ILE E CB  1 
ATOM   4439 C CG1 . ILE C 1 96  ? 138.396 100.703 118.047 1.00 77.26  ? 167 ILE E CG1 1 
ATOM   4440 C CG2 . ILE C 1 96  ? 137.797 102.666 116.611 1.00 77.26  ? 167 ILE E CG2 1 
ATOM   4441 C CD1 . ILE C 1 96  ? 137.955 99.650  117.054 1.00 77.26  ? 167 ILE E CD1 1 
ATOM   4442 N N   . THR C 1 97  ? 140.289 103.112 114.530 1.00 82.96  ? 168 THR E N   1 
ATOM   4443 C CA  . THR C 1 97  ? 140.602 104.346 113.827 1.00 82.96  ? 168 THR E CA  1 
ATOM   4444 C C   . THR C 1 97  ? 139.744 105.490 114.361 1.00 82.96  ? 168 THR E C   1 
ATOM   4445 O O   . THR C 1 97  ? 138.595 105.296 114.767 1.00 82.96  ? 168 THR E O   1 
ATOM   4446 C CB  . THR C 1 97  ? 140.378 104.174 112.323 1.00 82.96  ? 168 THR E CB  1 
ATOM   4447 O OG1 . THR C 1 97  ? 140.973 102.945 111.889 1.00 82.96  ? 168 THR E OG1 1 
ATOM   4448 C CG2 . THR C 1 97  ? 141.004 105.325 111.547 1.00 82.96  ? 168 THR E CG2 1 
ATOM   4449 N N   . GLU C 1 98  ? 140.321 106.695 114.365 1.00 86.62  ? 169 GLU E N   1 
ATOM   4450 C CA  . GLU C 1 98  ? 139.599 107.858 114.873 1.00 86.62  ? 169 GLU E CA  1 
ATOM   4451 C C   . GLU C 1 98  ? 138.357 108.151 114.039 1.00 86.62  ? 169 GLU E C   1 
ATOM   4452 O O   . GLU C 1 98  ? 137.322 108.559 114.579 1.00 86.62  ? 169 GLU E O   1 
ATOM   4453 C CB  . GLU C 1 98  ? 140.520 109.078 114.910 1.00 86.62  ? 169 GLU E CB  1 
ATOM   4454 C CG  . GLU C 1 98  ? 141.644 108.979 115.927 1.00 86.62  ? 169 GLU E CG  1 
ATOM   4455 C CD  . GLU C 1 98  ? 142.430 110.269 116.051 1.00 86.62  ? 169 GLU E CD  1 
ATOM   4456 O OE1 . GLU C 1 98  ? 142.091 111.244 115.347 1.00 86.62  ? 169 GLU E OE1 1 
ATOM   4457 O OE2 . GLU C 1 98  ? 143.386 110.310 116.853 1.00 86.62  ? 169 GLU E OE2 1 
ATOM   4458 N N   . GLN C 1 99  ? 138.444 107.961 112.720 1.00 86.29  ? 170 GLN E N   1 
ATOM   4459 C CA  . GLN C 1 99  ? 137.285 108.190 111.863 1.00 86.29  ? 170 GLN E CA  1 
ATOM   4460 C C   . GLN C 1 99  ? 136.146 107.240 112.209 1.00 86.29  ? 170 GLN E C   1 
ATOM   4461 O O   . GLN C 1 99  ? 134.979 107.649 112.261 1.00 86.29  ? 170 GLN E O   1 
ATOM   4462 C CB  . GLN C 1 99  ? 137.681 108.043 110.394 1.00 86.29  ? 170 GLN E CB  1 
ATOM   4463 C CG  . GLN C 1 99  ? 138.759 109.013 109.941 1.00 86.29  ? 170 GLN E CG  1 
ATOM   4464 C CD  . GLN C 1 99  ? 139.145 108.816 108.488 1.00 86.29  ? 170 GLN E CD  1 
ATOM   4465 O OE1 . GLN C 1 99  ? 138.644 107.914 107.817 1.00 86.29  ? 170 GLN E OE1 1 
ATOM   4466 N NE2 . GLN C 1 99  ? 140.042 109.663 107.994 1.00 86.29  ? 170 GLN E NE2 1 
ATOM   4467 N N   . GLN C 1 100 ? 136.463 105.964 112.442 1.00 81.89  ? 171 GLN E N   1 
ATOM   4468 C CA  . GLN C 1 100 ? 135.437 105.004 112.837 1.00 81.89  ? 171 GLN E CA  1 
ATOM   4469 C C   . GLN C 1 100 ? 134.858 105.343 114.206 1.00 81.89  ? 171 GLN E C   1 
ATOM   4470 O O   . GLN C 1 100 ? 133.647 105.222 114.422 1.00 81.89  ? 171 GLN E O   1 
ATOM   4471 C CB  . GLN C 1 100 ? 136.015 103.589 112.833 1.00 81.89  ? 171 GLN E CB  1 
ATOM   4472 C CG  . GLN C 1 100 ? 136.566 103.147 111.487 1.00 81.89  ? 171 GLN E CG  1 
ATOM   4473 C CD  . GLN C 1 100 ? 137.195 101.768 111.540 1.00 81.89  ? 171 GLN E CD  1 
ATOM   4474 O OE1 . GLN C 1 100 ? 137.289 101.156 112.604 1.00 81.89  ? 171 GLN E OE1 1 
ATOM   4475 N NE2 . GLN C 1 100 ? 137.631 101.272 110.388 1.00 81.89  ? 171 GLN E NE2 1 
ATOM   4476 N N   . TRP C 1 101 ? 135.711 105.764 115.143 1.00 78.39  ? 172 TRP E N   1 
ATOM   4477 C CA  . TRP C 1 101 ? 135.244 106.080 116.490 1.00 78.39  ? 172 TRP E CA  1 
ATOM   4478 C C   . TRP C 1 101 ? 134.342 107.309 116.493 1.00 78.39  ? 172 TRP E C   1 
ATOM   4479 O O   . TRP C 1 101 ? 133.374 107.374 117.260 1.00 78.39  ? 172 TRP E O   1 
ATOM   4480 C CB  . TRP C 1 101 ? 136.439 106.283 117.421 1.00 78.39  ? 172 TRP E CB  1 
ATOM   4481 C CG  . TRP C 1 101 ? 136.063 106.469 118.857 1.00 78.39  ? 172 TRP E CG  1 
ATOM   4482 C CD1 . TRP C 1 101 ? 135.961 107.651 119.531 1.00 78.39  ? 172 TRP E CD1 1 
ATOM   4483 C CD2 . TRP C 1 101 ? 135.737 105.440 119.800 1.00 78.39  ? 172 TRP E CD2 1 
ATOM   4484 N NE1 . TRP C 1 101 ? 135.594 107.421 120.835 1.00 78.39  ? 172 TRP E NE1 1 
ATOM   4485 C CE2 . TRP C 1 101 ? 135.449 106.072 121.025 1.00 78.39  ? 172 TRP E CE2 1 
ATOM   4486 C CE3 . TRP C 1 101 ? 135.661 104.046 119.726 1.00 78.39  ? 172 TRP E CE3 1 
ATOM   4487 C CZ2 . TRP C 1 101 ? 135.091 105.359 122.167 1.00 78.39  ? 172 TRP E CZ2 1 
ATOM   4488 C CZ3 . TRP C 1 101 ? 135.305 103.340 120.861 1.00 78.39  ? 172 TRP E CZ3 1 
ATOM   4489 C CH2 . TRP C 1 101 ? 135.024 103.997 122.065 1.00 78.39  ? 172 TRP E CH2 1 
ATOM   4490 N N   . MET C 1 102 ? 134.642 108.294 115.644 1.00 80.85  ? 173 MET E N   1 
ATOM   4491 C CA  . MET C 1 102 ? 133.851 109.515 115.569 1.00 80.85  ? 173 MET E CA  1 
ATOM   4492 C C   . MET C 1 102 ? 132.516 109.325 114.860 1.00 80.85  ? 173 MET E C   1 
ATOM   4493 O O   . MET C 1 102 ? 131.705 110.257 114.846 1.00 80.85  ? 173 MET E O   1 
ATOM   4494 C CB  . MET C 1 102 ? 134.647 110.616 114.864 1.00 80.85  ? 173 MET E CB  1 
ATOM   4495 C CG  . MET C 1 102 ? 135.742 111.235 115.714 1.00 80.85  ? 173 MET E CG  1 
ATOM   4496 S SD  . MET C 1 102 ? 135.089 112.050 117.184 1.00 80.85  ? 173 MET E SD  1 
ATOM   4497 C CE  . MET C 1 102 ? 136.567 112.842 117.812 1.00 80.85  ? 173 MET E CE  1 
ATOM   4498 N N   . SER C 1 103 ? 132.267 108.152 114.277 1.00 83.33  ? 174 SER E N   1 
ATOM   4499 C CA  . SER C 1 103 ? 131.030 107.901 113.546 1.00 83.33  ? 174 SER E CA  1 
ATOM   4500 C C   . SER C 1 103 ? 129.879 107.570 114.489 1.00 83.33  ? 174 SER E C   1 
ATOM   4501 O O   . SER C 1 103 ? 128.848 107.048 114.053 1.00 83.33  ? 174 SER E O   1 
ATOM   4502 C CB  . SER C 1 103 ? 131.230 106.767 112.538 1.00 83.33  ? 174 SER E CB  1 
ATOM   4503 O OG  . SER C 1 103 ? 131.608 105.567 113.190 1.00 83.33  ? 174 SER E OG  1 
ATOM   4504 N N   . GLU C 1 104 ? 130.049 107.870 115.779 1.00 81.73  ? 175 GLU E N   1 
ATOM   4505 C CA  . GLU C 1 104 ? 129.042 107.587 116.805 1.00 81.73  ? 175 GLU E CA  1 
ATOM   4506 C C   . GLU C 1 104 ? 128.682 106.103 116.832 1.00 81.73  ? 175 GLU E C   1 
ATOM   4507 O O   . GLU C 1 104 ? 127.522 105.728 117.010 1.00 81.73  ? 175 GLU E O   1 
ATOM   4508 C CB  . GLU C 1 104 ? 127.789 108.447 116.615 1.00 81.73  ? 175 GLU E CB  1 
ATOM   4509 C CG  . GLU C 1 104 ? 128.002 109.935 116.859 1.00 81.73  ? 175 GLU E CG  1 
ATOM   4510 C CD  . GLU C 1 104 ? 128.601 110.649 115.663 1.00 81.73  ? 175 GLU E CD  1 
ATOM   4511 O OE1 . GLU C 1 104 ? 128.376 110.194 114.522 1.00 81.73  ? 175 GLU E OE1 1 
ATOM   4512 O OE2 . GLU C 1 104 ? 129.296 111.666 115.863 1.00 81.73  ? 175 GLU E OE2 1 
ATOM   4513 N N   . SER C 1 105 ? 129.688 105.252 116.652 1.00 83.82  ? 176 SER E N   1 
ATOM   4514 C CA  . SER C 1 105 ? 129.485 103.810 116.689 1.00 83.82  ? 176 SER E CA  1 
ATOM   4515 C C   . SER C 1 105 ? 129.393 103.350 118.138 1.00 83.82  ? 176 SER E C   1 
ATOM   4516 O O   . SER C 1 105 ? 130.278 103.645 118.948 1.00 83.82  ? 176 SER E O   1 
ATOM   4517 C CB  . SER C 1 105 ? 130.621 103.093 115.963 1.00 83.82  ? 176 SER E CB  1 
ATOM   4518 O OG  . SER C 1 105 ? 130.692 103.495 114.607 1.00 83.82  ? 176 SER E OG  1 
ATOM   4519 N N   . THR C 1 106 ? 128.321 102.626 118.464 1.00 80.89  ? 177 THR E N   1 
ATOM   4520 C CA  . THR C 1 106 ? 128.090 102.143 119.824 1.00 80.89  ? 177 THR E CA  1 
ATOM   4521 C C   . THR C 1 106 ? 128.878 100.850 120.019 1.00 80.89  ? 177 THR E C   1 
ATOM   4522 O O   . THR C 1 106 ? 128.367 99.736  119.877 1.00 80.89  ? 177 THR E O   1 
ATOM   4523 C CB  . THR C 1 106 ? 126.602 101.940 120.081 1.00 80.89  ? 177 THR E CB  1 
ATOM   4524 O OG1 . THR C 1 106 ? 125.890 103.131 119.725 1.00 80.89  ? 177 THR E OG1 1 
ATOM   4525 C CG2 . THR C 1 106 ? 126.353 101.632 121.550 1.00 80.89  ? 177 THR E CG2 1 
ATOM   4526 N N   . PHE C 1 107 ? 130.158 101.012 120.343 1.00 79.44  ? 178 PHE E N   1 
ATOM   4527 C CA  . PHE C 1 107 ? 131.014 99.863  120.597 1.00 79.44  ? 178 PHE E CA  1 
ATOM   4528 C C   . PHE C 1 107 ? 130.577 99.141  121.865 1.00 79.44  ? 178 PHE E C   1 
ATOM   4529 O O   . PHE C 1 107 ? 130.184 99.765  122.856 1.00 79.44  ? 178 PHE E O   1 
ATOM   4530 C CB  . PHE C 1 107 ? 132.474 100.299 120.707 1.00 79.44  ? 178 PHE E CB  1 
ATOM   4531 C CG  . PHE C 1 107 ? 133.152 100.471 119.378 1.00 79.44  ? 178 PHE E CG  1 
ATOM   4532 C CD1 . PHE C 1 107 ? 133.127 101.691 118.723 1.00 79.44  ? 178 PHE E CD1 1 
ATOM   4533 C CD2 . PHE C 1 107 ? 133.807 99.407  118.780 1.00 79.44  ? 178 PHE E CD2 1 
ATOM   4534 C CE1 . PHE C 1 107 ? 133.749 101.848 117.497 1.00 79.44  ? 178 PHE E CE1 1 
ATOM   4535 C CE2 . PHE C 1 107 ? 134.430 99.558  117.556 1.00 79.44  ? 178 PHE E CE2 1 
ATOM   4536 C CZ  . PHE C 1 107 ? 134.401 100.779 116.914 1.00 79.44  ? 178 PHE E CZ  1 
ATOM   4537 N N   . THR C 1 108 ? 130.632 97.811  121.817 1.00 89.10  ? 179 THR E N   1 
ATOM   4538 C CA  . THR C 1 108 ? 130.133 96.974  122.898 1.00 89.10  ? 179 THR E CA  1 
ATOM   4539 C C   . THR C 1 108 ? 131.057 95.785  123.105 1.00 89.10  ? 179 THR E C   1 
ATOM   4540 O O   . THR C 1 108 ? 131.494 95.154  122.137 1.00 89.10  ? 179 THR E O   1 
ATOM   4541 C CB  . THR C 1 108 ? 128.710 96.486  122.598 1.00 89.10  ? 179 THR E CB  1 
ATOM   4542 O OG1 . THR C 1 108 ? 127.863 97.615  122.353 1.00 89.10  ? 179 THR E OG1 1 
ATOM   4543 C CG2 . THR C 1 108 ? 128.154 95.686  123.767 1.00 89.10  ? 179 THR E CG2 1 
ATOM   4544 N N   . CYS C 1 109 ? 131.346 95.489  124.368 1.00 95.61  ? 180 CYS E N   1 
ATOM   4545 C CA  . CYS C 1 109 ? 132.070 94.285  124.755 1.00 95.61  ? 180 CYS E CA  1 
ATOM   4546 C C   . CYS C 1 109 ? 131.084 93.290  125.353 1.00 95.61  ? 180 CYS E C   1 
ATOM   4547 O O   . CYS C 1 109 ? 130.338 93.631  126.278 1.00 95.61  ? 180 CYS E O   1 
ATOM   4548 C CB  . CYS C 1 109 ? 133.182 94.602  125.759 1.00 95.61  ? 180 CYS E CB  1 
ATOM   4549 S SG  . CYS C 1 109 ? 134.249 93.191  126.166 1.00 95.61  ? 180 CYS E SG  1 
ATOM   4550 N N   . LYS C 1 110 ? 131.074 92.071  124.819 1.00 99.23  ? 181 LYS E N   1 
ATOM   4551 C CA  . LYS C 1 110 ? 130.169 91.020  125.260 1.00 99.23  ? 181 LYS E CA  1 
ATOM   4552 C C   . LYS C 1 110 ? 130.977 89.846  125.791 1.00 99.23  ? 181 LYS E C   1 
ATOM   4553 O O   . LYS C 1 110 ? 131.919 89.387  125.134 1.00 99.23  ? 181 LYS E O   1 
ATOM   4554 C CB  . LYS C 1 110 ? 129.255 90.557  124.122 1.00 99.23  ? 181 LYS E CB  1 
ATOM   4555 C CG  . LYS C 1 110 ? 128.300 89.441  124.518 1.00 99.23  ? 181 LYS E CG  1 
ATOM   4556 C CD  . LYS C 1 110 ? 127.419 89.018  123.355 1.00 99.23  ? 181 LYS E CD  1 
ATOM   4557 C CE  . LYS C 1 110 ? 128.239 88.397  122.238 1.00 99.23  ? 181 LYS E CE  1 
ATOM   4558 N NZ  . LYS C 1 110 ? 127.383 87.947  121.107 1.00 99.23  ? 181 LYS E NZ  1 
ATOM   4559 N N   . VAL C 1 111 ? 130.604 89.366  126.976 1.00 103.17 ? 182 VAL E N   1 
ATOM   4560 C CA  . VAL C 1 111 ? 131.266 88.242  127.627 1.00 103.17 ? 182 VAL E CA  1 
ATOM   4561 C C   . VAL C 1 111 ? 130.209 87.219  128.015 1.00 103.17 ? 182 VAL E C   1 
ATOM   4562 O O   . VAL C 1 111 ? 129.190 87.572  128.619 1.00 103.17 ? 182 VAL E O   1 
ATOM   4563 C CB  . VAL C 1 111 ? 132.067 88.687  128.867 1.00 103.17 ? 182 VAL E CB  1 
ATOM   4564 C CG1 . VAL C 1 111 ? 132.762 87.495  129.509 1.00 103.17 ? 182 VAL E CG1 1 
ATOM   4565 C CG2 . VAL C 1 111 ? 133.075 89.763  128.493 1.00 103.17 ? 182 VAL E CG2 1 
ATOM   4566 N N   . THR C 1 112 ? 130.449 85.955  127.673 1.00 106.00 ? 183 THR E N   1 
ATOM   4567 C CA  . THR C 1 112 ? 129.536 84.863  128.000 1.00 106.00 ? 183 THR E CA  1 
ATOM   4568 C C   . THR C 1 112 ? 130.032 84.176  129.268 1.00 106.00 ? 183 THR E C   1 
ATOM   4569 O O   . THR C 1 112 ? 131.043 83.466  129.243 1.00 106.00 ? 183 THR E O   1 
ATOM   4570 C CB  . THR C 1 112 ? 129.434 83.869  126.845 1.00 106.00 ? 183 THR E CB  1 
ATOM   4571 O OG1 . THR C 1 112 ? 128.935 84.537  125.679 1.00 106.00 ? 183 THR E OG1 1 
ATOM   4572 C CG2 . THR C 1 112 ? 128.499 82.724  127.208 1.00 106.00 ? 183 THR E CG2 1 
ATOM   4573 N N   . SER C 1 113 ? 129.321 84.389  130.373 1.00 106.95 ? 184 SER E N   1 
ATOM   4574 C CA  . SER C 1 113 ? 129.650 83.782  131.657 1.00 106.95 ? 184 SER E CA  1 
ATOM   4575 C C   . SER C 1 113 ? 128.459 82.965  132.135 1.00 106.95 ? 184 SER E C   1 
ATOM   4576 O O   . SER C 1 113 ? 127.352 83.499  132.269 1.00 106.95 ? 184 SER E O   1 
ATOM   4577 C CB  . SER C 1 113 ? 130.022 84.848  132.690 1.00 106.95 ? 184 SER E CB  1 
ATOM   4578 O OG  . SER C 1 113 ? 130.329 84.261  133.943 1.00 106.95 ? 184 SER E OG  1 
ATOM   4579 N N   . GLN C 1 114 ? 128.691 81.675  132.387 1.00 106.43 ? 185 GLN E N   1 
ATOM   4580 C CA  . GLN C 1 114 ? 127.664 80.764  132.897 1.00 106.43 ? 185 GLN E CA  1 
ATOM   4581 C C   . GLN C 1 114 ? 126.426 80.768  132.001 1.00 106.43 ? 185 GLN E C   1 
ATOM   4582 O O   . GLN C 1 114 ? 125.287 80.716  132.471 1.00 106.43 ? 185 GLN E O   1 
ATOM   4583 C CB  . GLN C 1 114 ? 127.299 81.107  134.344 1.00 106.43 ? 185 GLN E CB  1 
ATOM   4584 C CG  . GLN C 1 114 ? 126.720 79.944  135.139 1.00 106.43 ? 185 GLN E CG  1 
ATOM   4585 C CD  . GLN C 1 114 ? 126.389 80.323  136.569 1.00 106.43 ? 185 GLN E CD  1 
ATOM   4586 O OE1 . GLN C 1 114 ? 126.565 81.472  136.975 1.00 106.43 ? 185 GLN E OE1 1 
ATOM   4587 N NE2 . GLN C 1 114 ? 125.907 79.356  137.341 1.00 106.43 ? 185 GLN E NE2 1 
ATOM   4588 N N   . GLY C 1 115 ? 126.652 80.836  130.692 1.00 105.39 ? 186 GLY E N   1 
ATOM   4589 C CA  . GLY C 1 115 ? 125.563 80.833  129.738 1.00 105.39 ? 186 GLY E CA  1 
ATOM   4590 C C   . GLY C 1 115 ? 124.811 82.137  129.612 1.00 105.39 ? 186 GLY E C   1 
ATOM   4591 O O   . GLY C 1 115 ? 123.781 82.174  128.928 1.00 105.39 ? 186 GLY E O   1 
ATOM   4592 N N   . VAL C 1 116 ? 125.285 83.207  130.245 1.00 104.27 ? 187 VAL E N   1 
ATOM   4593 C CA  . VAL C 1 116 ? 124.634 84.511  130.203 1.00 104.27 ? 187 VAL E CA  1 
ATOM   4594 C C   . VAL C 1 116 ? 125.561 85.484  129.489 1.00 104.27 ? 187 VAL E C   1 
ATOM   4595 O O   . VAL C 1 116 ? 126.745 85.586  129.830 1.00 104.27 ? 187 VAL E O   1 
ATOM   4596 C CB  . VAL C 1 116 ? 124.285 85.015  131.614 1.00 104.27 ? 187 VAL E CB  1 
ATOM   4597 C CG1 . VAL C 1 116 ? 123.569 86.355  131.537 1.00 104.27 ? 187 VAL E CG1 1 
ATOM   4598 C CG2 . VAL C 1 116 ? 123.435 83.990  132.348 1.00 104.27 ? 187 VAL E CG2 1 
ATOM   4599 N N   . ASP C 1 117 ? 125.025 86.191  128.497 1.00 105.23 ? 188 ASP E N   1 
ATOM   4600 C CA  . ASP C 1 117 ? 125.802 87.148  127.712 1.00 105.23 ? 188 ASP E CA  1 
ATOM   4601 C C   . ASP C 1 117 ? 125.647 88.529  128.337 1.00 105.23 ? 188 ASP E C   1 
ATOM   4602 O O   . ASP C 1 117 ? 124.586 89.151  128.245 1.00 105.23 ? 188 ASP E O   1 
ATOM   4603 C CB  . ASP C 1 117 ? 125.348 87.143  126.256 1.00 105.23 ? 188 ASP E CB  1 
ATOM   4604 C CG  . ASP C 1 117 ? 125.547 85.798  125.588 1.00 105.23 ? 188 ASP E CG  1 
ATOM   4605 O OD1 . ASP C 1 117 ? 126.498 85.082  125.965 1.00 105.23 ? 188 ASP E OD1 1 
ATOM   4606 O OD2 . ASP C 1 117 ? 124.754 85.456  124.686 1.00 105.23 ? 188 ASP E OD2 1 
ATOM   4607 N N   . TYR C 1 118 ? 126.709 89.011  128.978 1.00 102.36 ? 189 TYR E N   1 
ATOM   4608 C CA  . TYR C 1 118 ? 126.723 90.358  129.534 1.00 102.36 ? 189 TYR E CA  1 
ATOM   4609 C C   . TYR C 1 118 ? 127.369 91.302  128.529 1.00 102.36 ? 189 TYR E C   1 
ATOM   4610 O O   . TYR C 1 118 ? 128.492 91.057  128.072 1.00 102.36 ? 189 TYR E O   1 
ATOM   4611 C CB  . TYR C 1 118 ? 127.478 90.382  130.862 1.00 102.36 ? 189 TYR E CB  1 
ATOM   4612 C CG  . TYR C 1 118 ? 126.939 89.421  131.897 1.00 102.36 ? 189 TYR E CG  1 
ATOM   4613 C CD1 . TYR C 1 118 ? 125.913 89.796  132.754 1.00 102.36 ? 189 TYR E CD1 1 
ATOM   4614 C CD2 . TYR C 1 118 ? 127.462 88.140  132.022 1.00 102.36 ? 189 TYR E CD2 1 
ATOM   4615 C CE1 . TYR C 1 118 ? 125.419 88.921  133.703 1.00 102.36 ? 189 TYR E CE1 1 
ATOM   4616 C CE2 . TYR C 1 118 ? 126.974 87.258  132.967 1.00 102.36 ? 189 TYR E CE2 1 
ATOM   4617 C CZ  . TYR C 1 118 ? 125.954 87.654  133.805 1.00 102.36 ? 189 TYR E CZ  1 
ATOM   4618 O OH  . TYR C 1 118 ? 125.466 86.779  134.749 1.00 102.36 ? 189 TYR E OH  1 
ATOM   4619 N N   . LEU C 1 119 ? 126.664 92.376  128.183 1.00 96.23  ? 190 LEU E N   1 
ATOM   4620 C CA  . LEU C 1 119 ? 127.117 93.334  127.185 1.00 96.23  ? 190 LEU E CA  1 
ATOM   4621 C C   . LEU C 1 119 ? 127.292 94.703  127.823 1.00 96.23  ? 190 LEU E C   1 
ATOM   4622 O O   . LEU C 1 119 ? 126.494 95.111  128.673 1.00 96.23  ? 190 LEU E O   1 
ATOM   4623 C CB  . LEU C 1 119 ? 126.130 93.435  126.012 1.00 96.23  ? 190 LEU E CB  1 
ATOM   4624 C CG  . LEU C 1 119 ? 125.997 92.251  125.049 1.00 96.23  ? 190 LEU E CG  1 
ATOM   4625 C CD1 . LEU C 1 119 ? 125.141 91.137  125.637 1.00 96.23  ? 190 LEU E CD1 1 
ATOM   4626 C CD2 . LEU C 1 119 ? 125.436 92.710  123.710 1.00 96.23  ? 190 LEU E CD2 1 
ATOM   4627 N N   . ALA C 1 120 ? 128.340 95.411  127.407 1.00 92.10  ? 191 ALA E N   1 
ATOM   4628 C CA  . ALA C 1 120 ? 128.605 96.762  127.890 1.00 92.10  ? 191 ALA E CA  1 
ATOM   4629 C C   . ALA C 1 120 ? 128.873 97.661  126.695 1.00 92.10  ? 191 ALA E C   1 
ATOM   4630 O O   . ALA C 1 120 ? 129.818 97.417  125.937 1.00 92.10  ? 191 ALA E O   1 
ATOM   4631 C CB  . ALA C 1 120 ? 129.793 96.787  128.857 1.00 92.10  ? 191 ALA E CB  1 
ATOM   4632 N N   . HIS C 1 121 ? 128.053 98.698  126.537 1.00 85.57  ? 192 HIS E N   1 
ATOM   4633 C CA  . HIS C 1 121 ? 128.171 99.647  125.438 1.00 85.57  ? 192 HIS E CA  1 
ATOM   4634 C C   . HIS C 1 121 ? 128.824 100.924 125.961 1.00 85.57  ? 192 HIS E C   1 
ATOM   4635 O O   . HIS C 1 121 ? 128.405 101.458 126.994 1.00 85.57  ? 192 HIS E O   1 
ATOM   4636 C CB  . HIS C 1 121 ? 126.798 99.951  124.832 1.00 85.57  ? 192 HIS E CB  1 
ATOM   4637 C CG  . HIS C 1 121 ? 125.962 98.735  124.564 1.00 85.57  ? 192 HIS E CG  1 
ATOM   4638 N ND1 . HIS C 1 121 ? 125.781 98.218  123.299 1.00 85.57  ? 192 HIS E ND1 1 
ATOM   4639 C CD2 . HIS C 1 121 ? 125.241 97.947  125.397 1.00 85.57  ? 192 HIS E CD2 1 
ATOM   4640 C CE1 . HIS C 1 121 ? 124.993 97.160  123.365 1.00 85.57  ? 192 HIS E CE1 1 
ATOM   4641 N NE2 . HIS C 1 121 ? 124.652 96.973  124.627 1.00 85.57  ? 192 HIS E NE2 1 
ATOM   4642 N N   . THR C 1 122 ? 129.851 101.407 125.257 1.00 76.21  ? 193 THR E N   1 
ATOM   4643 C CA  . THR C 1 122 ? 130.584 102.581 125.729 1.00 76.21  ? 193 THR E CA  1 
ATOM   4644 C C   . THR C 1 122 ? 130.116 103.897 125.114 1.00 76.21  ? 193 THR E C   1 
ATOM   4645 O O   . THR C 1 122 ? 129.657 104.788 125.838 1.00 76.21  ? 193 THR E O   1 
ATOM   4646 C CB  . THR C 1 122 ? 132.085 102.423 125.467 1.00 76.21  ? 193 THR E CB  1 
ATOM   4647 O OG1 . THR C 1 122 ? 132.292 101.622 124.298 1.00 76.21  ? 193 THR E OG1 1 
ATOM   4648 C CG2 . THR C 1 122 ? 132.776 101.783 126.658 1.00 76.21  ? 193 THR E CG2 1 
ATOM   4649 N N   . ARG C 1 123 ? 130.251 104.033 123.789 1.00 69.77  ? 194 ARG E N   1 
ATOM   4650 C CA  . ARG C 1 123 ? 130.113 105.308 123.082 1.00 69.77  ? 194 ARG E CA  1 
ATOM   4651 C C   . ARG C 1 123 ? 131.203 106.271 123.551 1.00 69.77  ? 194 ARG E C   1 
ATOM   4652 O O   . ARG C 1 123 ? 131.743 106.107 124.649 1.00 69.77  ? 194 ARG E O   1 
ATOM   4653 C CB  . ARG C 1 123 ? 128.717 105.909 123.276 1.00 69.77  ? 194 ARG E CB  1 
ATOM   4654 C CG  . ARG C 1 123 ? 128.309 106.897 122.201 1.00 69.77  ? 194 ARG E CG  1 
ATOM   4655 C CD  . ARG C 1 123 ? 126.874 107.337 122.402 1.00 69.77  ? 194 ARG E CD  1 
ATOM   4656 N NE  . ARG C 1 123 ? 125.982 106.194 122.544 1.00 69.77  ? 194 ARG E NE  1 
ATOM   4657 C CZ  . ARG C 1 123 ? 124.693 106.284 122.841 1.00 69.77  ? 194 ARG E CZ  1 
ATOM   4658 N NH1 . ARG C 1 123 ? 124.117 107.453 123.069 1.00 69.77  ? 194 ARG E NH1 1 
ATOM   4659 N NH2 . ARG C 1 123 ? 123.964 105.174 122.909 1.00 69.77  ? 194 ARG E NH2 1 
ATOM   4660 N N   . ARG C 1 124 ? 131.559 107.266 122.736 1.00 69.40  ? 195 ARG E N   1 
ATOM   4661 C CA  . ARG C 1 124 ? 132.668 108.135 123.117 1.00 69.40  ? 195 ARG E CA  1 
ATOM   4662 C C   . ARG C 1 124 ? 132.363 108.902 124.401 1.00 69.40  ? 195 ARG E C   1 
ATOM   4663 O O   . ARG C 1 124 ? 132.966 108.628 125.445 1.00 69.40  ? 195 ARG E O   1 
ATOM   4664 C CB  . ARG C 1 124 ? 132.998 109.105 121.979 1.00 69.40  ? 195 ARG E CB  1 
ATOM   4665 C CG  . ARG C 1 124 ? 131.784 109.571 121.186 1.00 69.40  ? 195 ARG E CG  1 
ATOM   4666 C CD  . ARG C 1 124 ? 132.148 110.677 120.209 1.00 69.40  ? 195 ARG E CD  1 
ATOM   4667 N NE  . ARG C 1 124 ? 130.993 111.153 119.457 1.00 69.40  ? 195 ARG E NE  1 
ATOM   4668 C CZ  . ARG C 1 124 ? 131.016 112.181 118.620 1.00 69.40  ? 195 ARG E CZ  1 
ATOM   4669 N NH1 . ARG C 1 124 ? 132.123 112.876 118.410 1.00 69.40  ? 195 ARG E NH1 1 
ATOM   4670 N NH2 . ARG C 1 124 ? 129.902 112.523 117.979 1.00 69.40  ? 195 ARG E NH2 1 
ATOM   4671 N N   . CYS C 1 125 ? 131.431 109.854 124.338 1.00 70.90  ? 196 CYS E N   1 
ATOM   4672 C CA  . CYS C 1 125 ? 130.822 110.475 125.509 1.00 70.90  ? 196 CYS E CA  1 
ATOM   4673 C C   . CYS C 1 125 ? 129.610 111.285 125.069 1.00 70.90  ? 196 CYS E C   1 
ATOM   4674 O O   . CYS C 1 125 ? 129.575 112.502 125.293 1.00 70.90  ? 196 CYS E O   1 
ATOM   4675 C CB  . CYS C 1 125 ? 131.817 111.367 126.255 1.00 70.90  ? 196 CYS E CB  1 
ATOM   4676 S SG  . CYS C 1 125 ? 131.231 111.969 127.867 1.00 70.90  ? 196 CYS E SG  1 
ATOM   4677 N N   . PRO C 1 126 ? 128.578 110.639 124.503 1.00 68.23  ? 197 PRO E N   1 
ATOM   4678 C CA  . PRO C 1 126 ? 127.496 111.363 123.820 1.00 68.23  ? 197 PRO E CA  1 
ATOM   4679 C C   . PRO C 1 126 ? 127.820 112.756 123.289 1.00 68.23  ? 197 PRO E C   1 
ATOM   4680 O O   . PRO C 1 126 ? 126.996 113.668 123.399 1.00 68.23  ? 197 PRO E O   1 
ATOM   4681 C CB  . PRO C 1 126 ? 126.415 111.395 124.904 1.00 68.23  ? 197 PRO E CB  1 
ATOM   4682 C CG  . PRO C 1 126 ? 126.656 110.039 125.674 1.00 68.23  ? 197 PRO E CG  1 
ATOM   4683 C CD  . PRO C 1 126 ? 128.012 109.484 125.208 1.00 68.23  ? 197 PRO E CD  1 
ATOM   4684 N N   . ASP C 1 127 ? 129.011 112.914 122.721 1.00 63.30  ? 198 ASP E N   1 
ATOM   4685 C CA  . ASP C 1 127 ? 129.547 114.146 122.124 1.00 63.30  ? 198 ASP E CA  1 
ATOM   4686 C C   . ASP C 1 127 ? 129.244 115.345 123.031 1.00 63.30  ? 198 ASP E C   1 
ATOM   4687 O O   . ASP C 1 127 ? 129.282 115.237 124.261 1.00 63.30  ? 198 ASP E O   1 
ATOM   4688 C CB  . ASP C 1 127 ? 129.050 114.286 120.687 1.00 63.30  ? 198 ASP E CB  1 
ATOM   4689 C CG  . ASP C 1 127 ? 127.538 114.279 120.576 1.00 63.30  ? 198 ASP E CG  1 
ATOM   4690 O OD1 . ASP C 1 127 ? 126.902 115.269 120.990 1.00 63.30  ? 198 ASP E OD1 1 
ATOM   4691 O OD2 . ASP C 1 127 ? 126.985 113.281 120.068 1.00 63.30  ? 198 ASP E OD2 1 
ATOM   4692 N N   . HIS C 1 128 ? 128.953 116.498 122.431 1.00 50.94  ? 199 HIS E N   1 
ATOM   4693 C CA  . HIS C 1 128 ? 128.742 117.738 123.170 1.00 50.94  ? 199 HIS E CA  1 
ATOM   4694 C C   . HIS C 1 128 ? 127.544 118.474 122.585 1.00 50.94  ? 199 HIS E C   1 
ATOM   4695 O O   . HIS C 1 128 ? 126.740 117.870 121.870 1.00 50.94  ? 199 HIS E O   1 
ATOM   4696 C CB  . HIS C 1 128 ? 129.998 118.612 123.128 1.00 50.94  ? 199 HIS E CB  1 
ATOM   4697 C CG  . HIS C 1 128 ? 130.062 119.637 124.219 1.00 50.94  ? 199 HIS E CG  1 
ATOM   4698 N ND1 . HIS C 1 128 ? 129.627 119.385 125.503 1.00 50.94  ? 199 HIS E ND1 1 
ATOM   4699 C CD2 . HIS C 1 128 ? 130.511 120.914 124.219 1.00 50.94  ? 199 HIS E CD2 1 
ATOM   4700 C CE1 . HIS C 1 128 ? 129.803 120.463 126.245 1.00 50.94  ? 199 HIS E CE1 1 
ATOM   4701 N NE2 . HIS C 1 128 ? 130.339 121.406 125.490 1.00 50.94  ? 199 HIS E NE2 1 
ATOM   4702 N N   . GLU C 1 129 ? 127.402 119.765 122.900 1.00 40.91  ? 200 GLU E N   1 
ATOM   4703 C CA  . GLU C 1 129 ? 126.289 120.570 122.416 1.00 40.91  ? 200 GLU E CA  1 
ATOM   4704 C C   . GLU C 1 129 ? 126.231 120.515 120.896 1.00 40.91  ? 200 GLU E C   1 
ATOM   4705 O O   . GLU C 1 129 ? 127.116 121.075 120.230 1.00 40.91  ? 200 GLU E O   1 
ATOM   4706 C CB  . GLU C 1 129 ? 126.425 122.015 122.897 1.00 40.91  ? 200 GLU E CB  1 
ATOM   4707 C CG  . GLU C 1 129 ? 127.829 122.596 122.774 1.00 40.91  ? 200 GLU E CG  1 
ATOM   4708 C CD  . GLU C 1 129 ? 127.955 123.961 123.418 1.00 40.91  ? 200 GLU E CD  1 
ATOM   4709 O OE1 . GLU C 1 129 ? 127.255 124.212 124.419 1.00 40.91  ? 200 GLU E OE1 1 
ATOM   4710 O OE2 . GLU C 1 129 ? 128.753 124.784 122.920 1.00 40.91  ? 200 GLU E OE2 1 
ATOM   4711 N N   . PRO C 1 130 ? 125.236 119.853 120.305 1.00 31.92  ? 201 PRO E N   1 
ATOM   4712 C CA  . PRO C 1 130 ? 125.191 119.719 118.846 1.00 31.92  ? 201 PRO E CA  1 
ATOM   4713 C C   . PRO C 1 130 ? 124.337 120.791 118.188 1.00 31.92  ? 201 PRO E C   1 
ATOM   4714 O O   . PRO C 1 130 ? 123.252 121.139 118.660 1.00 31.92  ? 201 PRO E O   1 
ATOM   4715 C CB  . PRO C 1 130 ? 124.574 118.326 118.657 1.00 31.92  ? 201 PRO E CB  1 
ATOM   4716 C CG  . PRO C 1 130 ? 123.838 118.026 119.979 1.00 31.92  ? 201 PRO E CG  1 
ATOM   4717 C CD  . PRO C 1 130 ? 124.111 119.153 120.942 1.00 31.92  ? 201 PRO E CD  1 
ATOM   4718 N N   . ARG C 1 131 ? 124.842 121.308 117.065 1.00 25.80  ? 202 ARG E N   1 
ATOM   4719 C CA  . ARG C 1 131 ? 124.179 122.380 116.321 1.00 25.80  ? 202 ARG E CA  1 
ATOM   4720 C C   . ARG C 1 131 ? 123.862 123.562 117.235 1.00 25.80  ? 202 ARG E C   1 
ATOM   4721 O O   . ARG C 1 131 ? 122.782 124.152 117.176 1.00 25.80  ? 202 ARG E O   1 
ATOM   4722 C CB  . ARG C 1 131 ? 122.913 121.870 115.629 1.00 25.80  ? 202 ARG E CB  1 
ATOM   4723 C CG  . ARG C 1 131 ? 123.155 120.758 114.621 1.00 25.80  ? 202 ARG E CG  1 
ATOM   4724 C CD  . ARG C 1 131 ? 123.988 121.244 113.447 1.00 25.80  ? 202 ARG E CD  1 
ATOM   4725 N NE  . ARG C 1 131 ? 124.177 120.203 112.445 1.00 25.80  ? 202 ARG E NE  1 
ATOM   4726 C CZ  . ARG C 1 131 ? 124.827 120.372 111.301 1.00 25.80  ? 202 ARG E CZ  1 
ATOM   4727 N NH1 . ARG C 1 131 ? 125.367 121.536 110.979 1.00 25.80  ? 202 ARG E NH1 1 
ATOM   4728 N NH2 . ARG C 1 131 ? 124.938 119.348 110.460 1.00 25.80  ? 202 ARG E NH2 1 
ATOM   4729 N N   . GLY C 1 132 ? 124.817 123.907 118.089 1.00 25.16  ? 203 GLY E N   1 
ATOM   4730 C CA  . GLY C 1 132 ? 124.560 124.906 119.113 1.00 25.16  ? 203 GLY E CA  1 
ATOM   4731 C C   . GLY C 1 132 ? 123.839 124.275 120.281 1.00 25.16  ? 203 GLY E C   1 
ATOM   4732 O O   . GLY C 1 132 ? 124.196 123.179 120.724 1.00 25.16  ? 203 GLY E O   1 
ATOM   4733 N N   . VAL C 1 133 ? 122.816 124.968 120.784 1.00 21.76  ? 204 VAL E N   1 
ATOM   4734 C CA  . VAL C 1 133 ? 121.961 124.475 121.861 1.00 21.76  ? 204 VAL E CA  1 
ATOM   4735 C C   . VAL C 1 133 ? 122.800 124.170 123.096 1.00 21.76  ? 204 VAL E C   1 
ATOM   4736 O O   . VAL C 1 133 ? 123.183 123.019 123.336 1.00 21.76  ? 204 VAL E O   1 
ATOM   4737 C CB  . VAL C 1 133 ? 121.156 123.237 121.418 1.00 21.76  ? 204 VAL E CB  1 
ATOM   4738 C CG1 . VAL C 1 133 ? 120.142 122.847 122.485 1.00 21.76  ? 204 VAL E CG1 1 
ATOM   4739 C CG2 . VAL C 1 133 ? 120.462 123.502 120.089 1.00 21.76  ? 204 VAL E CG2 1 
ATOM   4740 N N   . ILE C 1 134 ? 123.096 125.199 123.882 1.00 21.10  ? 205 ILE E N   1 
ATOM   4741 C CA  . ILE C 1 134 ? 123.826 125.040 125.133 1.00 21.10  ? 205 ILE E CA  1 
ATOM   4742 C C   . ILE C 1 134 ? 122.825 124.723 126.236 1.00 21.10  ? 205 ILE E C   1 
ATOM   4743 O O   . ILE C 1 134 ? 121.792 125.392 126.360 1.00 21.10  ? 205 ILE E O   1 
ATOM   4744 C CB  . ILE C 1 134 ? 124.635 126.303 125.465 1.00 21.10  ? 205 ILE E CB  1 
ATOM   4745 C CG1 . ILE C 1 134 ? 125.357 126.817 124.218 1.00 21.10  ? 205 ILE E CG1 1 
ATOM   4746 C CG2 . ILE C 1 134 ? 125.635 126.014 126.570 1.00 21.10  ? 205 ILE E CG2 1 
ATOM   4747 C CD1 . ILE C 1 134 ? 126.174 128.068 124.457 1.00 21.10  ? 205 ILE E CD1 1 
ATOM   4748 N N   . THR C 1 135 ? 123.125 123.695 127.027 1.00 19.33  ? 206 THR E N   1 
ATOM   4749 C CA  . THR C 1 135 ? 122.231 123.205 128.067 1.00 19.33  ? 206 THR E CA  1 
ATOM   4750 C C   . THR C 1 135 ? 122.773 123.584 129.438 1.00 19.33  ? 206 THR E C   1 
ATOM   4751 O O   . THR C 1 135 ? 123.943 123.324 129.742 1.00 19.33  ? 206 THR E O   1 
ATOM   4752 C CB  . THR C 1 135 ? 122.064 121.686 127.975 1.00 19.33  ? 206 THR E CB  1 
ATOM   4753 O OG1 . THR C 1 135 ? 123.297 121.047 128.329 1.00 19.33  ? 206 THR E OG1 1 
ATOM   4754 C CG2 . THR C 1 135 ? 121.684 121.279 126.561 1.00 19.33  ? 206 THR E CG2 1 
ATOM   4755 N N   . TYR C 1 136 ? 121.919 124.188 130.262 1.00 17.48  ? 207 TYR E N   1 
ATOM   4756 C CA  . TYR C 1 136 ? 122.261 124.575 131.625 1.00 17.48  ? 207 TYR E CA  1 
ATOM   4757 C C   . TYR C 1 136 ? 121.199 124.022 132.561 1.00 17.48  ? 207 TYR E C   1 
ATOM   4758 O O   . TYR C 1 136 ? 120.019 124.366 132.437 1.00 17.48  ? 207 TYR E O   1 
ATOM   4759 C CB  . TYR C 1 136 ? 122.358 126.097 131.762 1.00 17.48  ? 207 TYR E CB  1 
ATOM   4760 C CG  . TYR C 1 136 ? 123.463 126.723 130.940 1.00 17.48  ? 207 TYR E CG  1 
ATOM   4761 C CD1 . TYR C 1 136 ? 124.711 126.121 130.845 1.00 17.48  ? 207 TYR E CD1 1 
ATOM   4762 C CD2 . TYR C 1 136 ? 123.256 127.913 130.256 1.00 17.48  ? 207 TYR E CD2 1 
ATOM   4763 C CE1 . TYR C 1 136 ? 125.723 126.689 130.095 1.00 17.48  ? 207 TYR E CE1 1 
ATOM   4764 C CE2 . TYR C 1 136 ? 124.262 128.489 129.502 1.00 17.48  ? 207 TYR E CE2 1 
ATOM   4765 C CZ  . TYR C 1 136 ? 125.493 127.874 129.427 1.00 17.48  ? 207 TYR E CZ  1 
ATOM   4766 O OH  . TYR C 1 136 ? 126.498 128.442 128.678 1.00 17.48  ? 207 TYR E OH  1 
ATOM   4767 N N   . LEU C 1 137 ? 121.612 123.173 133.495 1.00 19.21  ? 208 LEU E N   1 
ATOM   4768 C CA  . LEU C 1 137 ? 120.707 122.538 134.448 1.00 19.21  ? 208 LEU E CA  1 
ATOM   4769 C C   . LEU C 1 137 ? 120.961 123.173 135.812 1.00 19.21  ? 208 LEU E C   1 
ATOM   4770 O O   . LEU C 1 137 ? 121.898 122.791 136.519 1.00 19.21  ? 208 LEU E O   1 
ATOM   4771 C CB  . LEU C 1 137 ? 120.926 121.028 134.468 1.00 19.21  ? 208 LEU E CB  1 
ATOM   4772 C CG  . LEU C 1 137 ? 119.925 120.155 135.221 1.00 19.21  ? 208 LEU E CG  1 
ATOM   4773 C CD1 . LEU C 1 137 ? 118.505 120.611 134.949 1.00 19.21  ? 208 LEU E CD1 1 
ATOM   4774 C CD2 . LEU C 1 137 ? 120.104 118.709 134.798 1.00 19.21  ? 208 LEU E CD2 1 
ATOM   4775 N N   . ILE C 1 138 ? 120.127 124.141 136.178 1.00 18.93  ? 209 ILE E N   1 
ATOM   4776 C CA  . ILE C 1 138 ? 120.359 124.970 137.356 1.00 18.93  ? 209 ILE E CA  1 
ATOM   4777 C C   . ILE C 1 138 ? 119.769 124.254 138.569 1.00 18.93  ? 209 ILE E C   1 
ATOM   4778 O O   . ILE C 1 138 ? 118.573 123.926 138.554 1.00 18.93  ? 209 ILE E O   1 
ATOM   4779 C CB  . ILE C 1 138 ? 119.748 126.366 137.193 1.00 18.93  ? 209 ILE E CB  1 
ATOM   4780 C CG1 . ILE C 1 138 ? 120.372 127.085 135.996 1.00 18.93  ? 209 ILE E CG1 1 
ATOM   4781 C CG2 . ILE C 1 138 ? 119.935 127.181 138.465 1.00 18.93  ? 209 ILE E CG2 1 
ATOM   4782 C CD1 . ILE C 1 138 ? 119.819 128.474 135.761 1.00 18.93  ? 209 ILE E CD1 1 
ATOM   4783 N N   . PRO C 1 139 ? 120.550 124.001 139.615 1.00 18.37  ? 210 PRO E N   1 
ATOM   4784 C CA  . PRO C 1 139 ? 120.006 123.370 140.822 1.00 18.37  ? 210 PRO E CA  1 
ATOM   4785 C C   . PRO C 1 139 ? 119.064 124.312 141.547 1.00 18.37  ? 210 PRO E C   1 
ATOM   4786 O O   . PRO C 1 139 ? 119.123 125.535 141.348 1.00 18.37  ? 210 PRO E O   1 
ATOM   4787 C CB  . PRO C 1 139 ? 121.260 123.076 141.659 1.00 18.37  ? 210 PRO E CB  1 
ATOM   4788 C CG  . PRO C 1 139 ? 122.253 124.089 141.205 1.00 18.37  ? 210 PRO E CG  1 
ATOM   4789 C CD  . PRO C 1 139 ? 121.990 124.287 139.738 1.00 18.37  ? 210 PRO E CD  1 
ATOM   4790 N N   . PRO C 1 140 ? 118.171 123.784 142.386 1.00 17.49  ? 211 PRO E N   1 
ATOM   4791 C CA  . PRO C 1 140 ? 117.227 124.653 143.098 1.00 17.49  ? 211 PRO E CA  1 
ATOM   4792 C C   . PRO C 1 140 ? 117.945 125.625 144.022 1.00 17.49  ? 211 PRO E C   1 
ATOM   4793 O O   . PRO C 1 140 ? 119.008 125.328 144.571 1.00 17.49  ? 211 PRO E O   1 
ATOM   4794 C CB  . PRO C 1 140 ? 116.362 123.666 143.893 1.00 17.49  ? 211 PRO E CB  1 
ATOM   4795 C CG  . PRO C 1 140 ? 116.538 122.353 143.202 1.00 17.49  ? 211 PRO E CG  1 
ATOM   4796 C CD  . PRO C 1 140 ? 117.941 122.361 142.684 1.00 17.49  ? 211 PRO E CD  1 
ATOM   4797 N N   . SER C 1 141 ? 117.349 126.804 144.181 1.00 20.98  ? 212 SER E N   1 
ATOM   4798 C CA  . SER C 1 141 ? 117.916 127.806 145.069 1.00 20.98  ? 212 SER E CA  1 
ATOM   4799 C C   . SER C 1 141 ? 117.882 127.306 146.512 1.00 20.98  ? 212 SER E C   1 
ATOM   4800 O O   . SER C 1 141 ? 116.874 126.743 146.952 1.00 20.98  ? 212 SER E O   1 
ATOM   4801 C CB  . SER C 1 141 ? 117.150 129.123 144.953 1.00 20.98  ? 212 SER E CB  1 
ATOM   4802 O OG  . SER C 1 141 ? 115.788 128.953 145.307 1.00 20.98  ? 212 SER E OG  1 
ATOM   4803 N N   . PRO C 1 142 ? 118.960 127.497 147.272 1.00 21.51  ? 213 PRO E N   1 
ATOM   4804 C CA  . PRO C 1 142 ? 118.998 126.970 148.643 1.00 21.51  ? 213 PRO E CA  1 
ATOM   4805 C C   . PRO C 1 142 ? 118.231 127.837 149.628 1.00 21.51  ? 213 PRO E C   1 
ATOM   4806 O O   . PRO C 1 142 ? 118.720 128.127 150.724 1.00 21.51  ? 213 PRO E O   1 
ATOM   4807 C CB  . PRO C 1 142 ? 120.499 126.953 148.974 1.00 21.51  ? 213 PRO E CB  1 
ATOM   4808 C CG  . PRO C 1 142 ? 121.213 127.274 147.674 1.00 21.51  ? 213 PRO E CG  1 
ATOM   4809 C CD  . PRO C 1 142 ? 120.251 128.071 146.868 1.00 21.51  ? 213 PRO E CD  1 
ATOM   4810 N N   . LEU C 1 143 ? 117.023 128.254 149.249 1.00 24.27  ? 214 LEU E N   1 
ATOM   4811 C CA  . LEU C 1 143 ? 116.171 129.054 150.118 1.00 24.27  ? 214 LEU E CA  1 
ATOM   4812 C C   . LEU C 1 143 ? 114.722 128.594 150.151 1.00 24.27  ? 214 LEU E C   1 
ATOM   4813 O O   . LEU C 1 143 ? 114.040 128.852 151.150 1.00 24.27  ? 214 LEU E O   1 
ATOM   4814 C CB  . LEU C 1 143 ? 116.218 130.531 149.695 1.00 24.27  ? 214 LEU E CB  1 
ATOM   4815 C CG  . LEU C 1 143 ? 115.678 131.593 150.655 1.00 24.27  ? 214 LEU E CG  1 
ATOM   4816 C CD1 . LEU C 1 143 ? 116.575 132.817 150.628 1.00 24.27  ? 214 LEU E CD1 1 
ATOM   4817 C CD2 . LEU C 1 143 ? 114.250 131.978 150.298 1.00 24.27  ? 214 LEU E CD2 1 
ATOM   4818 N N   . ASP C 1 144 ? 114.234 127.916 149.115 1.00 24.45  ? 215 ASP E N   1 
ATOM   4819 C CA  . ASP C 1 144 ? 112.857 127.450 149.061 1.00 24.45  ? 215 ASP E CA  1 
ATOM   4820 C C   . ASP C 1 144 ? 112.710 125.983 149.441 1.00 24.45  ? 215 ASP E C   1 
ATOM   4821 O O   . ASP C 1 144 ? 111.595 125.455 149.390 1.00 24.45  ? 215 ASP E O   1 
ATOM   4822 C CB  . ASP C 1 144 ? 112.279 127.677 147.661 1.00 24.45  ? 215 ASP E CB  1 
ATOM   4823 C CG  . ASP C 1 144 ? 112.355 129.129 147.228 1.00 24.45  ? 215 ASP E CG  1 
ATOM   4824 O OD1 . ASP C 1 144 ? 112.276 130.016 148.103 1.00 24.45  ? 215 ASP E OD1 1 
ATOM   4825 O OD2 . ASP C 1 144 ? 112.495 129.380 146.013 1.00 24.45  ? 215 ASP E OD2 1 
ATOM   4826 N N   . LEU C 1 145 ? 113.800 125.310 149.808 1.00 25.19  ? 216 LEU E N   1 
ATOM   4827 C CA  . LEU C 1 145 ? 113.705 123.908 150.211 1.00 25.19  ? 216 LEU E CA  1 
ATOM   4828 C C   . LEU C 1 145 ? 113.269 123.789 151.669 1.00 25.19  ? 216 LEU E C   1 
ATOM   4829 O O   . LEU C 1 145 ? 112.227 123.199 151.972 1.00 25.19  ? 216 LEU E O   1 
ATOM   4830 C CB  . LEU C 1 145 ? 115.042 123.196 149.974 1.00 25.19  ? 216 LEU E CB  1 
ATOM   4831 C CG  . LEU C 1 145 ? 115.317 122.656 148.565 1.00 25.19  ? 216 LEU E CG  1 
ATOM   4832 C CD1 . LEU C 1 145 ? 115.549 123.779 147.563 1.00 25.19  ? 216 LEU E CD1 1 
ATOM   4833 C CD2 . LEU C 1 145 ? 116.497 121.693 148.578 1.00 25.19  ? 216 LEU E CD2 1 
ATOM   4834 N N   . TYR C 1 146 ? 114.060 124.343 152.585 1.00 29.05  ? 217 TYR E N   1 
ATOM   4835 C CA  . TYR C 1 146 ? 113.758 124.266 154.013 1.00 29.05  ? 217 TYR E CA  1 
ATOM   4836 C C   . TYR C 1 146 ? 113.268 125.622 154.521 1.00 29.05  ? 217 TYR E C   1 
ATOM   4837 O O   . TYR C 1 146 ? 113.938 126.319 155.285 1.00 29.05  ? 217 TYR E O   1 
ATOM   4838 C CB  . TYR C 1 146 ? 114.984 123.784 154.782 1.00 29.05  ? 217 TYR E CB  1 
ATOM   4839 C CG  . TYR C 1 146 ? 115.577 122.510 154.226 1.00 29.05  ? 217 TYR E CG  1 
ATOM   4840 C CD1 . TYR C 1 146 ? 114.983 121.281 154.474 1.00 29.05  ? 217 TYR E CD1 1 
ATOM   4841 C CD2 . TYR C 1 146 ? 116.730 122.538 153.451 1.00 29.05  ? 217 TYR E CD2 1 
ATOM   4842 C CE1 . TYR C 1 146 ? 115.519 120.113 153.968 1.00 29.05  ? 217 TYR E CE1 1 
ATOM   4843 C CE2 . TYR C 1 146 ? 117.274 121.374 152.941 1.00 29.05  ? 217 TYR E CE2 1 
ATOM   4844 C CZ  . TYR C 1 146 ? 116.664 120.165 153.202 1.00 29.05  ? 217 TYR E CZ  1 
ATOM   4845 O OH  . TYR C 1 146 ? 117.201 119.003 152.698 1.00 29.05  ? 217 TYR E OH  1 
ATOM   4846 N N   . GLN C 1 147 ? 112.053 125.971 154.093 1.00 32.85  ? 218 GLN E N   1 
ATOM   4847 C CA  . GLN C 1 147 ? 111.415 127.228 154.474 1.00 32.85  ? 218 GLN E CA  1 
ATOM   4848 C C   . GLN C 1 147 ? 109.985 127.261 153.948 1.00 32.85  ? 218 GLN E C   1 
ATOM   4849 O O   . GLN C 1 147 ? 109.115 126.543 154.450 1.00 32.85  ? 218 GLN E O   1 
ATOM   4850 C CB  . GLN C 1 147 ? 112.207 128.426 153.941 1.00 32.85  ? 218 GLN E CB  1 
ATOM   4851 C CG  . GLN C 1 147 ? 111.906 129.742 154.644 1.00 32.85  ? 218 GLN E CG  1 
ATOM   4852 C CD  . GLN C 1 147 ? 112.366 129.756 156.089 1.00 32.85  ? 218 GLN E CD  1 
ATOM   4853 O OE1 . GLN C 1 147 ? 113.261 129.006 156.478 1.00 32.85  ? 218 GLN E OE1 1 
ATOM   4854 N NE2 . GLN C 1 147 ? 111.751 130.615 156.895 1.00 32.85  ? 218 GLN E NE2 1 
ATOM   4855 N N   . ASN C 1 148 ? 109.733 128.097 152.945 1.00 37.90  ? 219 ASN E N   1 
ATOM   4856 C CA  . ASN C 1 148 ? 108.460 128.081 152.244 1.00 37.90  ? 219 ASN E CA  1 
ATOM   4857 C C   . ASN C 1 148 ? 108.436 126.930 151.243 1.00 37.90  ? 219 ASN E C   1 
ATOM   4858 O O   . ASN C 1 148 ? 109.469 126.350 150.900 1.00 37.90  ? 219 ASN E O   1 
ATOM   4859 C CB  . ASN C 1 148 ? 108.217 129.411 151.531 1.00 37.90  ? 219 ASN E CB  1 
ATOM   4860 C CG  . ASN C 1 148 ? 108.216 130.591 152.483 1.00 37.90  ? 219 ASN E CG  1 
ATOM   4861 O OD1 . ASN C 1 148 ? 107.854 130.460 153.652 1.00 37.90  ? 219 ASN E OD1 1 
ATOM   4862 N ND2 . ASN C 1 148 ? 108.622 131.753 151.985 1.00 37.90  ? 219 ASN E ND2 1 
ATOM   4863 N N   . GLY C 1 149 ? 107.236 126.595 150.778 1.00 34.63  ? 220 GLY E N   1 
ATOM   4864 C CA  . GLY C 1 149 ? 107.097 125.478 149.865 1.00 34.63  ? 220 GLY E CA  1 
ATOM   4865 C C   . GLY C 1 149 ? 107.105 125.869 148.402 1.00 34.63  ? 220 GLY E C   1 
ATOM   4866 O O   . GLY C 1 149 ? 106.057 126.193 147.835 1.00 34.63  ? 220 GLY E O   1 
ATOM   4867 N N   . ALA C 1 150 ? 108.283 125.832 147.777 1.00 24.60  ? 221 ALA E N   1 
ATOM   4868 C CA  . ALA C 1 150 ? 108.402 126.066 146.343 1.00 24.60  ? 221 ALA E CA  1 
ATOM   4869 C C   . ALA C 1 150 ? 109.714 125.506 145.801 1.00 24.60  ? 221 ALA E C   1 
ATOM   4870 O O   . ALA C 1 150 ? 110.555 126.269 145.310 1.00 24.60  ? 221 ALA E O   1 
ATOM   4871 C CB  . ALA C 1 150 ? 108.304 127.561 146.030 1.00 24.60  ? 221 ALA E CB  1 
ATOM   4872 N N   . PRO C 1 151 ? 109.929 124.187 145.862 1.00 19.74  ? 222 PRO E N   1 
ATOM   4873 C CA  . PRO C 1 151 ? 111.163 123.620 145.305 1.00 19.74  ? 222 PRO E CA  1 
ATOM   4874 C C   . PRO C 1 151 ? 111.005 123.209 143.849 1.00 19.74  ? 222 PRO E C   1 
ATOM   4875 O O   . PRO C 1 151 ? 110.066 122.485 143.502 1.00 19.74  ? 222 PRO E O   1 
ATOM   4876 C CB  . PRO C 1 151 ? 111.426 122.412 146.212 1.00 19.74  ? 222 PRO E CB  1 
ATOM   4877 C CG  . PRO C 1 151 ? 110.065 122.071 146.833 1.00 19.74  ? 222 PRO E CG  1 
ATOM   4878 C CD  . PRO C 1 151 ? 109.072 123.138 146.437 1.00 19.74  ? 222 PRO E CD  1 
ATOM   4879 N N   . LYS C 1 152 ? 111.916 123.658 142.988 1.00 15.28  ? 223 LYS E N   1 
ATOM   4880 C CA  . LYS C 1 152 ? 111.818 123.358 141.567 1.00 15.28  ? 223 LYS E CA  1 
ATOM   4881 C C   . LYS C 1 152 ? 113.211 123.231 140.969 1.00 15.28  ? 223 LYS E C   1 
ATOM   4882 O O   . LYS C 1 152 ? 114.176 123.814 141.469 1.00 15.28  ? 223 LYS E O   1 
ATOM   4883 C CB  . LYS C 1 152 ? 111.021 124.435 140.821 1.00 15.28  ? 223 LYS E CB  1 
ATOM   4884 C CG  . LYS C 1 152 ? 111.633 125.824 140.898 1.00 15.28  ? 223 LYS E CG  1 
ATOM   4885 C CD  . LYS C 1 152 ? 110.817 126.834 140.110 1.00 15.28  ? 223 LYS E CD  1 
ATOM   4886 C CE  . LYS C 1 152 ? 111.444 128.217 140.172 1.00 15.28  ? 223 LYS E CE  1 
ATOM   4887 N NZ  . LYS C 1 152 ? 110.660 129.217 139.397 1.00 15.28  ? 223 LYS E NZ  1 
ATOM   4888 N N   . LEU C 1 153 ? 113.298 122.462 139.887 1.00 15.06  ? 224 LEU E N   1 
ATOM   4889 C CA  . LEU C 1 153 ? 114.524 122.280 139.123 1.00 15.06  ? 224 LEU E CA  1 
ATOM   4890 C C   . LEU C 1 153 ? 114.292 122.773 137.702 1.00 15.06  ? 224 LEU E C   1 
ATOM   4891 O O   . LEU C 1 153 ? 113.268 122.448 137.090 1.00 15.06  ? 224 LEU E O   1 
ATOM   4892 C CB  . LEU C 1 153 ? 114.957 120.812 139.119 1.00 15.06  ? 224 LEU E CB  1 
ATOM   4893 C CG  . LEU C 1 153 ? 116.175 120.446 139.968 1.00 15.06  ? 224 LEU E CG  1 
ATOM   4894 C CD1 . LEU C 1 153 ? 116.288 118.940 140.115 1.00 15.06  ? 224 LEU E CD1 1 
ATOM   4895 C CD2 . LEU C 1 153 ? 117.438 121.014 139.348 1.00 15.06  ? 224 LEU E CD2 1 
ATOM   4896 N N   . THR C 1 154 ? 115.238 123.551 137.180 1.00 14.91  ? 225 THR E N   1 
ATOM   4897 C CA  . THR C 1 154 ? 115.087 124.199 135.885 1.00 14.91  ? 225 THR E CA  1 
ATOM   4898 C C   . THR C 1 154 ? 116.189 123.767 134.925 1.00 14.91  ? 225 THR E C   1 
ATOM   4899 O O   . THR C 1 154 ? 117.359 123.639 135.310 1.00 14.91  ? 225 THR E O   1 
ATOM   4900 C CB  . THR C 1 154 ? 115.084 125.727 136.027 1.00 14.91  ? 225 THR E CB  1 
ATOM   4901 O OG1 . THR C 1 154 ? 115.268 126.332 134.740 1.00 14.91  ? 225 THR E OG1 1 
ATOM   4902 C CG2 . THR C 1 154 ? 116.183 126.183 136.969 1.00 14.91  ? 225 THR E CG2 1 
ATOM   4903 N N   . CYS C 1 155 ? 115.790 123.535 133.675 1.00 15.97  ? 226 CYS E N   1 
ATOM   4904 C CA  . CYS C 1 155 ? 116.687 123.147 132.593 1.00 15.97  ? 226 CYS E CA  1 
ATOM   4905 C C   . CYS C 1 155 ? 116.473 124.118 131.442 1.00 15.97  ? 226 CYS E C   1 
ATOM   4906 O O   . CYS C 1 155 ? 115.349 124.255 130.947 1.00 15.97  ? 226 CYS E O   1 
ATOM   4907 C CB  . CYS C 1 155 ? 116.414 121.705 132.148 1.00 15.97  ? 226 CYS E CB  1 
ATOM   4908 S SG  . CYS C 1 155 ? 117.614 120.980 131.006 1.00 15.97  ? 226 CYS E SG  1 
ATOM   4909 N N   . LEU C 1 156 ? 117.540 124.791 131.018 1.00 16.28  ? 227 LEU E N   1 
ATOM   4910 C CA  . LEU C 1 156 ? 117.467 125.818 129.989 1.00 16.28  ? 227 LEU E CA  1 
ATOM   4911 C C   . LEU C 1 156 ? 118.328 125.416 128.802 1.00 16.28  ? 227 LEU E C   1 
ATOM   4912 O O   . LEU C 1 156 ? 119.504 125.078 128.968 1.00 16.28  ? 227 LEU E O   1 
ATOM   4913 C CB  . LEU C 1 156 ? 117.921 127.175 130.539 1.00 16.28  ? 227 LEU E CB  1 
ATOM   4914 C CG  . LEU C 1 156 ? 118.230 128.277 129.523 1.00 16.28  ? 227 LEU E CG  1 
ATOM   4915 C CD1 . LEU C 1 156 ? 117.009 128.613 128.681 1.00 16.28  ? 227 LEU E CD1 1 
ATOM   4916 C CD2 . LEU C 1 156 ? 118.758 129.519 130.226 1.00 16.28  ? 227 LEU E CD2 1 
ATOM   4917 N N   . VAL C 1 157 ? 117.745 125.461 127.608 1.00 17.67  ? 228 VAL E N   1 
ATOM   4918 C CA  . VAL C 1 157 ? 118.466 125.195 126.369 1.00 17.67  ? 228 VAL E CA  1 
ATOM   4919 C C   . VAL C 1 157 ? 118.446 126.469 125.537 1.00 17.67  ? 228 VAL E C   1 
ATOM   4920 O O   . VAL C 1 157 ? 117.372 127.004 125.233 1.00 17.67  ? 228 VAL E O   1 
ATOM   4921 C CB  . VAL C 1 157 ? 117.865 124.012 125.593 1.00 17.67  ? 228 VAL E CB  1 
ATOM   4922 C CG1 . VAL C 1 157 ? 118.353 122.702 126.180 1.00 17.67  ? 228 VAL E CG1 1 
ATOM   4923 C CG2 . VAL C 1 157 ? 116.348 124.064 125.626 1.00 17.67  ? 228 VAL E CG2 1 
ATOM   4924 N N   . VAL C 1 158 ? 119.631 126.957 125.175 1.00 19.36  ? 229 VAL E N   1 
ATOM   4925 C CA  . VAL C 1 158 ? 119.773 128.187 124.410 1.00 19.36  ? 229 VAL E CA  1 
ATOM   4926 C C   . VAL C 1 158 ? 120.449 127.867 123.081 1.00 19.36  ? 229 VAL E C   1 
ATOM   4927 O O   . VAL C 1 158 ? 120.888 126.743 122.833 1.00 19.36  ? 229 VAL E O   1 
ATOM   4928 C CB  . VAL C 1 158 ? 120.557 129.270 125.176 1.00 19.36  ? 229 VAL E CB  1 
ATOM   4929 C CG1 . VAL C 1 158 ? 119.837 129.637 126.463 1.00 19.36  ? 229 VAL E CG1 1 
ATOM   4930 C CG2 . VAL C 1 158 ? 121.971 128.796 125.466 1.00 19.36  ? 229 VAL E CG2 1 
ATOM   4931 N N   . ASP C 1 159 ? 120.520 128.885 122.220 1.00 19.75  ? 230 ASP E N   1 
ATOM   4932 C CA  . ASP C 1 159 ? 121.132 128.772 120.895 1.00 19.75  ? 230 ASP E CA  1 
ATOM   4933 C C   . ASP C 1 159 ? 120.445 127.694 120.057 1.00 19.75  ? 230 ASP E C   1 
ATOM   4934 O O   . ASP C 1 159 ? 121.082 126.781 119.529 1.00 19.75  ? 230 ASP E O   1 
ATOM   4935 C CB  . ASP C 1 159 ? 122.637 128.512 121.002 1.00 19.75  ? 230 ASP E CB  1 
ATOM   4936 C CG  . ASP C 1 159 ? 123.377 129.643 121.688 1.00 19.75  ? 230 ASP E CG  1 
ATOM   4937 O OD1 . ASP C 1 159 ? 122.723 130.632 122.080 1.00 19.75  ? 230 ASP E OD1 1 
ATOM   4938 O OD2 . ASP C 1 159 ? 124.614 129.543 121.836 1.00 19.75  ? 230 ASP E OD2 1 
ATOM   4939 N N   . LEU C 1 160 ? 119.125 127.808 119.938 1.00 21.33  ? 231 LEU E N   1 
ATOM   4940 C CA  . LEU C 1 160 ? 118.328 126.906 119.118 1.00 21.33  ? 231 LEU E CA  1 
ATOM   4941 C C   . LEU C 1 160 ? 117.917 127.616 117.835 1.00 21.33  ? 231 LEU E C   1 
ATOM   4942 O O   . LEU C 1 160 ? 117.396 128.735 117.880 1.00 21.33  ? 231 LEU E O   1 
ATOM   4943 C CB  . LEU C 1 160 ? 117.084 126.422 119.867 1.00 21.33  ? 231 LEU E CB  1 
ATOM   4944 C CG  . LEU C 1 160 ? 117.233 125.275 120.871 1.00 21.33  ? 231 LEU E CG  1 
ATOM   4945 C CD1 . LEU C 1 160 ? 117.859 125.754 122.168 1.00 21.33  ? 231 LEU E CD1 1 
ATOM   4946 C CD2 . LEU C 1 160 ? 115.886 124.617 121.134 1.00 21.33  ? 231 LEU E CD2 1 
ATOM   4947 N N   . GLU C 1 161 ? 118.161 126.965 116.695 1.00 25.94  ? 232 GLU E N   1 
ATOM   4948 C CA  . GLU C 1 161 ? 117.749 127.536 115.417 1.00 25.94  ? 232 GLU E CA  1 
ATOM   4949 C C   . GLU C 1 161 ? 116.233 127.663 115.335 1.00 25.94  ? 232 GLU E C   1 
ATOM   4950 O O   . GLU C 1 161 ? 115.712 128.682 114.866 1.00 25.94  ? 232 GLU E O   1 
ATOM   4951 C CB  . GLU C 1 161 ? 118.282 126.684 114.266 1.00 25.94  ? 232 GLU E CB  1 
ATOM   4952 C CG  . GLU C 1 161 ? 119.794 126.529 114.256 1.00 25.94  ? 232 GLU E CG  1 
ATOM   4953 C CD  . GLU C 1 161 ? 120.285 125.673 113.105 1.00 25.94  ? 232 GLU E CD  1 
ATOM   4954 O OE1 . GLU C 1 161 ? 119.454 125.276 112.262 1.00 25.94  ? 232 GLU E OE1 1 
ATOM   4955 O OE2 . GLU C 1 161 ? 121.501 125.396 113.045 1.00 25.94  ? 232 GLU E OE2 1 
ATOM   4956 N N   . SER C 1 162 ? 115.510 126.640 115.785 1.00 26.70  ? 233 SER E N   1 
ATOM   4957 C CA  . SER C 1 162 ? 114.056 126.670 115.786 1.00 26.70  ? 233 SER E CA  1 
ATOM   4958 C C   . SER C 1 162 ? 113.543 125.790 116.917 1.00 26.70  ? 233 SER E C   1 
ATOM   4959 O O   . SER C 1 162 ? 114.241 124.896 117.402 1.00 26.70  ? 233 SER E O   1 
ATOM   4960 C CB  . SER C 1 162 ? 113.480 126.208 114.442 1.00 26.70  ? 233 SER E CB  1 
ATOM   4961 O OG  . SER C 1 162 ? 113.881 124.882 114.144 1.00 26.70  ? 233 SER E OG  1 
ATOM   4962 N N   . GLU C 1 163 ? 112.307 126.058 117.332 1.00 31.42  ? 234 GLU E N   1 
ATOM   4963 C CA  . GLU C 1 163 ? 111.653 125.303 118.392 1.00 31.42  ? 234 GLU E CA  1 
ATOM   4964 C C   . GLU C 1 163 ? 110.757 124.191 117.864 1.00 31.42  ? 234 GLU E C   1 
ATOM   4965 O O   . GLU C 1 163 ? 110.095 123.519 118.660 1.00 31.42  ? 234 GLU E O   1 
ATOM   4966 C CB  . GLU C 1 163 ? 110.832 126.245 119.279 1.00 31.42  ? 234 GLU E CB  1 
ATOM   4967 C CG  . GLU C 1 163 ? 109.736 126.992 118.537 1.00 31.42  ? 234 GLU E CG  1 
ATOM   4968 C CD  . GLU C 1 163 ? 108.893 127.855 119.456 1.00 31.42  ? 234 GLU E CD  1 
ATOM   4969 O OE1 . GLU C 1 163 ? 109.108 127.802 120.685 1.00 31.42  ? 234 GLU E OE1 1 
ATOM   4970 O OE2 . GLU C 1 163 ? 108.016 128.585 118.949 1.00 31.42  ? 234 GLU E OE2 1 
ATOM   4971 N N   . LYS C 1 164 ? 110.719 123.983 116.551 1.00 31.30  ? 235 LYS E N   1 
ATOM   4972 C CA  . LYS C 1 164 ? 109.822 122.998 115.961 1.00 31.30  ? 235 LYS E CA  1 
ATOM   4973 C C   . LYS C 1 164 ? 110.343 121.586 116.202 1.00 31.30  ? 235 LYS E C   1 
ATOM   4974 O O   . LYS C 1 164 ? 111.509 121.288 115.923 1.00 31.30  ? 235 LYS E O   1 
ATOM   4975 C CB  . LYS C 1 164 ? 109.665 123.256 114.463 1.00 31.30  ? 235 LYS E CB  1 
ATOM   4976 C CG  . LYS C 1 164 ? 109.133 124.639 114.126 1.00 31.30  ? 235 LYS E CG  1 
ATOM   4977 C CD  . LYS C 1 164 ? 109.031 124.841 112.623 1.00 31.30  ? 235 LYS E CD  1 
ATOM   4978 C CE  . LYS C 1 164 ? 108.514 126.231 112.287 1.00 31.30  ? 235 LYS E CE  1 
ATOM   4979 N NZ  . LYS C 1 164 ? 108.416 126.447 110.817 1.00 31.30  ? 235 LYS E NZ  1 
ATOM   4980 N N   . ASN C 1 165 ? 109.467 120.720 116.718 1.00 30.43  ? 236 ASN E N   1 
ATOM   4981 C CA  . ASN C 1 165 ? 109.769 119.306 116.948 1.00 30.43  ? 236 ASN E CA  1 
ATOM   4982 C C   . ASN C 1 165 ? 110.948 119.113 117.900 1.00 30.43  ? 236 ASN E C   1 
ATOM   4983 O O   . ASN C 1 165 ? 111.696 118.139 117.790 1.00 30.43  ? 236 ASN E O   1 
ATOM   4984 C CB  . ASN C 1 165 ? 110.024 118.572 115.628 1.00 30.43  ? 236 ASN E CB  1 
ATOM   4985 C CG  . ASN C 1 165 ? 108.863 118.693 114.660 1.00 30.43  ? 236 ASN E CG  1 
ATOM   4986 O OD1 . ASN C 1 165 ? 107.708 118.810 115.070 1.00 30.43  ? 236 ASN E OD1 1 
ATOM   4987 N ND2 . ASN C 1 165 ? 109.165 118.666 113.367 1.00 30.43  ? 236 ASN E ND2 1 
ATOM   4988 N N   . VAL C 1 166 ? 111.118 120.033 118.846 1.00 26.13  ? 237 VAL E N   1 
ATOM   4989 C CA  . VAL C 1 166 ? 112.141 119.934 119.882 1.00 26.13  ? 237 VAL E CA  1 
ATOM   4990 C C   . VAL C 1 166 ? 111.424 119.695 121.202 1.00 26.13  ? 237 VAL E C   1 
ATOM   4991 O O   . VAL C 1 166 ? 110.549 120.481 121.588 1.00 26.13  ? 237 VAL E O   1 
ATOM   4992 C CB  . VAL C 1 166 ? 113.007 121.200 119.951 1.00 26.13  ? 237 VAL E CB  1 
ATOM   4993 C CG1 . VAL C 1 166 ? 114.299 120.924 120.708 1.00 26.13  ? 237 VAL E CG1 1 
ATOM   4994 C CG2 . VAL C 1 166 ? 113.289 121.729 118.556 1.00 26.13  ? 237 VAL E CG2 1 
ATOM   4995 N N   . ASN C 1 167 ? 111.785 118.619 121.898 1.00 26.43  ? 238 ASN E N   1 
ATOM   4996 C CA  . ASN C 1 167 ? 111.081 118.259 123.123 1.00 26.43  ? 238 ASN E CA  1 
ATOM   4997 C C   . ASN C 1 167 ? 112.059 117.957 124.248 1.00 26.43  ? 238 ASN E C   1 
ATOM   4998 O O   . ASN C 1 167 ? 113.114 117.353 124.030 1.00 26.43  ? 238 ASN E O   1 
ATOM   4999 C CB  . ASN C 1 167 ? 110.144 117.062 122.900 1.00 26.43  ? 238 ASN E CB  1 
ATOM   5000 C CG  . ASN C 1 167 ? 110.704 116.053 121.922 1.00 26.43  ? 238 ASN E CG  1 
ATOM   5001 O OD1 . ASN C 1 167 ? 111.917 115.915 121.780 1.00 26.43  ? 238 ASN E OD1 1 
ATOM   5002 N ND2 . ASN C 1 167 ? 109.815 115.340 121.238 1.00 26.43  ? 238 ASN E ND2 1 
ATOM   5003 N N   . VAL C 1 168 ? 111.688 118.375 125.456 1.00 22.41  ? 239 VAL E N   1 
ATOM   5004 C CA  . VAL C 1 168 ? 112.503 118.203 126.652 1.00 22.41  ? 239 VAL E CA  1 
ATOM   5005 C C   . VAL C 1 168 ? 111.708 117.393 127.666 1.00 22.41  ? 239 VAL E C   1 
ATOM   5006 O O   . VAL C 1 168 ? 110.568 117.742 127.992 1.00 22.41  ? 239 VAL E O   1 
ATOM   5007 C CB  . VAL C 1 168 ? 112.928 119.557 127.249 1.00 22.41  ? 239 VAL E CB  1 
ATOM   5008 C CG1 . VAL C 1 168 ? 113.748 119.347 128.511 1.00 22.41  ? 239 VAL E CG1 1 
ATOM   5009 C CG2 . VAL C 1 168 ? 113.710 120.368 126.226 1.00 22.41  ? 239 VAL E CG2 1 
ATOM   5010 N N   . THR C 1 169 ? 112.312 116.317 128.158 1.00 21.71  ? 240 THR E N   1 
ATOM   5011 C CA  . THR C 1 169 ? 111.733 115.465 129.183 1.00 21.71  ? 240 THR E CA  1 
ATOM   5012 C C   . THR C 1 169 ? 112.527 115.595 130.477 1.00 21.71  ? 240 THR E C   1 
ATOM   5013 O O   . THR C 1 169 ? 113.708 115.957 130.478 1.00 21.71  ? 240 THR E O   1 
ATOM   5014 C CB  . THR C 1 169 ? 111.699 113.999 128.733 1.00 21.71  ? 240 THR E CB  1 
ATOM   5015 O OG1 . THR C 1 169 ? 113.034 113.540 128.487 1.00 21.71  ? 240 THR E OG1 1 
ATOM   5016 C CG2 . THR C 1 169 ? 110.875 113.851 127.463 1.00 21.71  ? 240 THR E CG2 1 
ATOM   5017 N N   . TRP C 1 170 ? 111.864 115.262 131.580 1.00 19.30  ? 241 TRP E N   1 
ATOM   5018 C CA  . TRP C 1 170 ? 112.348 115.487 132.940 1.00 19.30  ? 241 TRP E CA  1 
ATOM   5019 C C   . TRP C 1 170 ? 112.347 114.186 133.727 1.00 19.30  ? 241 TRP E C   1 
ATOM   5020 O O   . TRP C 1 170 ? 111.774 114.088 134.815 1.00 19.30  ? 241 TRP E O   1 
ATOM   5021 C CB  . TRP C 1 170 ? 111.511 116.544 133.651 1.00 19.30  ? 241 TRP E CB  1 
ATOM   5022 C CG  . TRP C 1 170 ? 112.119 117.906 133.622 1.00 19.30  ? 241 TRP E CG  1 
ATOM   5023 C CD1 . TRP C 1 170 ? 111.797 118.932 132.784 1.00 19.30  ? 241 TRP E CD1 1 
ATOM   5024 C CD2 . TRP C 1 170 ? 113.163 118.394 134.472 1.00 19.30  ? 241 TRP E CD2 1 
ATOM   5025 N NE1 . TRP C 1 170 ? 112.575 120.030 133.060 1.00 19.30  ? 241 TRP E NE1 1 
ATOM   5026 C CE2 . TRP C 1 170 ? 113.422 119.726 134.093 1.00 19.30  ? 241 TRP E CE2 1 
ATOM   5027 C CE3 . TRP C 1 170 ? 113.904 117.835 135.518 1.00 19.30  ? 241 TRP E CE3 1 
ATOM   5028 C CZ2 . TRP C 1 170 ? 114.388 120.506 134.722 1.00 19.30  ? 241 TRP E CZ2 1 
ATOM   5029 C CZ3 . TRP C 1 170 ? 114.863 118.611 136.140 1.00 19.30  ? 241 TRP E CZ3 1 
ATOM   5030 C CH2 . TRP C 1 170 ? 115.097 119.932 135.740 1.00 19.30  ? 241 TRP E CH2 1 
ATOM   5031 N N   . ASN C 1 171 ? 112.977 113.158 133.161 1.00 20.61  ? 242 ASN E N   1 
ATOM   5032 C CA  . ASN C 1 171 ? 112.929 111.815 133.732 1.00 20.61  ? 242 ASN E CA  1 
ATOM   5033 C C   . ASN C 1 171 ? 113.376 111.815 135.187 1.00 20.61  ? 242 ASN E C   1 
ATOM   5034 O O   . ASN C 1 171 ? 114.527 112.134 135.497 1.00 20.61  ? 242 ASN E O   1 
ATOM   5035 C CB  . ASN C 1 171 ? 113.808 110.872 132.907 1.00 20.61  ? 242 ASN E CB  1 
ATOM   5036 C CG  . ASN C 1 171 ? 113.860 109.470 133.483 1.00 20.61  ? 242 ASN E CG  1 
ATOM   5037 O OD1 . ASN C 1 171 ? 114.739 109.147 134.281 1.00 20.61  ? 242 ASN E OD1 1 
ATOM   5038 N ND2 . ASN C 1 171 ? 112.914 108.629 133.079 1.00 20.61  ? 242 ASN E ND2 1 
ATOM   5039 N N   . GLN C 1 172 ? 112.457 111.458 136.080 1.00 21.01  ? 243 GLN E N   1 
ATOM   5040 C CA  . GLN C 1 172 ? 112.739 111.445 137.511 1.00 21.01  ? 243 GLN E CA  1 
ATOM   5041 C C   . GLN C 1 172 ? 113.400 110.119 137.868 1.00 21.01  ? 243 GLN E C   1 
ATOM   5042 O O   . GLN C 1 172 ? 112.745 109.073 137.886 1.00 21.01  ? 243 GLN E O   1 
ATOM   5043 C CB  . GLN C 1 172 ? 111.457 111.660 138.310 1.00 21.01  ? 243 GLN E CB  1 
ATOM   5044 C CG  . GLN C 1 172 ? 110.664 112.883 137.877 1.00 21.01  ? 243 GLN E CG  1 
ATOM   5045 C CD  . GLN C 1 172 ? 109.616 113.288 138.893 1.00 21.01  ? 243 GLN E CD  1 
ATOM   5046 O OE1 . GLN C 1 172 ? 109.680 112.894 140.057 1.00 21.01  ? 243 GLN E OE1 1 
ATOM   5047 N NE2 . GLN C 1 172 ? 108.643 114.080 138.457 1.00 21.01  ? 243 GLN E NE2 1 
ATOM   5048 N N   . GLU C 1 173 ? 114.699 110.164 138.149 1.00 24.18  ? 244 GLU E N   1 
ATOM   5049 C CA  . GLU C 1 173 ? 115.454 108.948 138.418 1.00 24.18  ? 244 GLU E CA  1 
ATOM   5050 C C   . GLU C 1 173 ? 115.107 108.394 139.794 1.00 24.18  ? 244 GLU E C   1 
ATOM   5051 O O   . GLU C 1 173 ? 115.119 109.124 140.790 1.00 24.18  ? 244 GLU E O   1 
ATOM   5052 C CB  . GLU C 1 173 ? 116.952 109.230 138.322 1.00 24.18  ? 244 GLU E CB  1 
ATOM   5053 C CG  . GLU C 1 173 ? 117.391 109.789 136.979 1.00 24.18  ? 244 GLU E CG  1 
ATOM   5054 C CD  . GLU C 1 173 ? 118.822 110.291 136.996 1.00 24.18  ? 244 GLU E CD  1 
ATOM   5055 O OE1 . GLU C 1 173 ? 119.391 110.429 138.099 1.00 24.18  ? 244 GLU E OE1 1 
ATOM   5056 O OE2 . GLU C 1 173 ? 119.377 110.547 135.906 1.00 24.18  ? 244 GLU E OE2 1 
ATOM   5057 N N   . LYS C 1 174 ? 114.776 107.101 139.836 1.00 26.21  ? 245 LYS E N   1 
ATOM   5058 C CA  . LYS C 1 174 ? 114.566 106.358 141.076 1.00 26.21  ? 245 LYS E CA  1 
ATOM   5059 C C   . LYS C 1 174 ? 113.380 106.873 141.886 1.00 26.21  ? 245 LYS E C   1 
ATOM   5060 O O   . LYS C 1 174 ? 113.129 106.387 142.994 1.00 26.21  ? 245 LYS E O   1 
ATOM   5061 C CB  . LYS C 1 174 ? 115.836 106.390 141.933 1.00 26.21  ? 245 LYS E CB  1 
ATOM   5062 C CG  . LYS C 1 174 ? 117.065 105.818 141.243 1.00 26.21  ? 245 LYS E CG  1 
ATOM   5063 C CD  . LYS C 1 174 ? 118.343 106.240 141.951 1.00 26.21  ? 245 LYS E CD  1 
ATOM   5064 C CE  . LYS C 1 174 ? 118.330 105.834 143.415 1.00 26.21  ? 245 LYS E CE  1 
ATOM   5065 N NZ  . LYS C 1 174 ? 119.558 106.290 144.124 1.00 26.21  ? 245 LYS E NZ  1 
ATOM   5066 N N   . LYS C 1 175 ? 112.647 107.841 141.356 1.00 20.81  ? 246 LYS E N   1 
ATOM   5067 C CA  . LYS C 1 175 ? 111.511 108.396 142.086 1.00 20.81  ? 246 LYS E CA  1 
ATOM   5068 C C   . LYS C 1 175 ? 110.224 108.409 141.274 1.00 20.81  ? 246 LYS E C   1 
ATOM   5069 O O   . LYS C 1 175 ? 109.151 108.180 141.838 1.00 20.81  ? 246 LYS E O   1 
ATOM   5070 C CB  . LYS C 1 175 ? 111.844 109.820 142.563 1.00 20.81  ? 246 LYS E CB  1 
ATOM   5071 C CG  . LYS C 1 175 ? 110.817 110.413 143.511 1.00 20.81  ? 246 LYS E CG  1 
ATOM   5072 C CD  . LYS C 1 175 ? 110.624 109.533 144.736 1.00 20.81  ? 246 LYS E CD  1 
ATOM   5073 C CE  . LYS C 1 175 ? 109.546 110.088 145.652 1.00 20.81  ? 246 LYS E CE  1 
ATOM   5074 N NZ  . LYS C 1 175 ? 109.345 109.234 146.855 1.00 20.81  ? 246 LYS E NZ  1 
ATOM   5075 N N   . THR C 1 176 ? 110.305 108.685 139.969 1.00 21.19  ? 247 THR E N   1 
ATOM   5076 C CA  . THR C 1 176 ? 109.163 108.693 139.057 1.00 21.19  ? 247 THR E CA  1 
ATOM   5077 C C   . THR C 1 176 ? 108.122 109.731 139.464 1.00 21.19  ? 247 THR E C   1 
ATOM   5078 O O   . THR C 1 176 ? 107.917 110.719 138.750 1.00 21.19  ? 247 THR E O   1 
ATOM   5079 C CB  . THR C 1 176 ? 108.515 107.305 138.965 1.00 21.19  ? 247 THR E CB  1 
ATOM   5080 O OG1 . THR C 1 176 ? 107.874 106.982 140.206 1.00 21.19  ? 247 THR E OG1 1 
ATOM   5081 C CG2 . THR C 1 176 ? 109.561 106.245 138.645 1.00 21.19  ? 247 THR E CG2 1 
ATOM   5082 N N   . SER C 1 177 ? 107.462 109.511 140.604 1.00 20.29  ? 248 SER E N   1 
ATOM   5083 C CA  . SER C 1 177 ? 106.449 110.420 141.135 1.00 20.29  ? 248 SER E CA  1 
ATOM   5084 C C   . SER C 1 177 ? 105.334 110.689 140.131 1.00 20.29  ? 248 SER E C   1 
ATOM   5085 O O   . SER C 1 177 ? 105.127 109.911 139.194 1.00 20.29  ? 248 SER E O   1 
ATOM   5086 C CB  . SER C 1 177 ? 107.087 111.741 141.574 1.00 20.29  ? 248 SER E CB  1 
ATOM   5087 O OG  . SER C 1 177 ? 107.951 111.548 142.679 1.00 20.29  ? 248 SER E OG  1 
ATOM   5088 N N   . VAL C 1 178 ? 104.605 111.790 140.328 1.00 20.00  ? 249 VAL E N   1 
ATOM   5089 C CA  . VAL C 1 178 ? 103.499 112.164 139.457 1.00 20.00  ? 249 VAL E CA  1 
ATOM   5090 C C   . VAL C 1 178 ? 103.582 113.611 138.994 1.00 20.00  ? 249 VAL E C   1 
ATOM   5091 O O   . VAL C 1 178 ? 102.771 114.032 138.167 1.00 20.00  ? 249 VAL E O   1 
ATOM   5092 C CB  . VAL C 1 178 ? 102.141 111.898 140.142 1.00 20.00  ? 249 VAL E CB  1 
ATOM   5093 C CG1 . VAL C 1 178 ? 101.776 113.044 141.080 1.00 20.00  ? 249 VAL E CG1 1 
ATOM   5094 C CG2 . VAL C 1 178 ? 101.044 111.647 139.111 1.00 20.00  ? 249 VAL E CG2 1 
ATOM   5095 N N   . SER C 1 179 ? 104.544 114.386 139.491 1.00 20.97  ? 250 SER E N   1 
ATOM   5096 C CA  . SER C 1 179 ? 104.645 115.792 139.122 1.00 20.97  ? 250 SER E CA  1 
ATOM   5097 C C   . SER C 1 179 ? 104.967 115.943 137.640 1.00 20.97  ? 250 SER E C   1 
ATOM   5098 O O   . SER C 1 179 ? 105.690 115.131 137.056 1.00 20.97  ? 250 SER E O   1 
ATOM   5099 C CB  . SER C 1 179 ? 105.716 116.484 139.966 1.00 20.97  ? 250 SER E CB  1 
ATOM   5100 O OG  . SER C 1 179 ? 105.415 116.393 141.347 1.00 20.97  ? 250 SER E OG  1 
ATOM   5101 N N   . ALA C 1 180 ? 104.421 116.994 137.033 1.00 21.29  ? 251 ALA E N   1 
ATOM   5102 C CA  . ALA C 1 180 ? 104.609 117.277 135.619 1.00 21.29  ? 251 ALA E CA  1 
ATOM   5103 C C   . ALA C 1 180 ? 105.378 118.579 135.446 1.00 21.29  ? 251 ALA E C   1 
ATOM   5104 O O   . ALA C 1 180 ? 105.248 119.509 136.248 1.00 21.29  ? 251 ALA E O   1 
ATOM   5105 C CB  . ALA C 1 180 ? 103.266 117.362 134.883 1.00 21.29  ? 251 ALA E CB  1 
ATOM   5106 N N   . SER C 1 181 ? 106.181 118.637 134.389 1.00 21.50  ? 252 SER E N   1 
ATOM   5107 C CA  . SER C 1 181 ? 107.007 119.799 134.103 1.00 21.50  ? 252 SER E CA  1 
ATOM   5108 C C   . SER C 1 181 ? 106.265 120.784 133.207 1.00 21.50  ? 252 SER E C   1 
ATOM   5109 O O   . SER C 1 181 ? 105.267 120.451 132.563 1.00 21.50  ? 252 SER E O   1 
ATOM   5110 C CB  . SER C 1 181 ? 108.316 119.375 133.435 1.00 21.50  ? 252 SER E CB  1 
ATOM   5111 O OG  . SER C 1 181 ? 108.958 118.356 134.178 1.00 21.50  ? 252 SER E OG  1 
ATOM   5112 N N   . GLN C 1 182 ? 106.770 122.016 133.174 1.00 23.37  ? 253 GLN E N   1 
ATOM   5113 C CA  . GLN C 1 182 ? 106.222 123.055 132.311 1.00 23.37  ? 253 GLN E CA  1 
ATOM   5114 C C   . GLN C 1 182 ? 107.368 123.767 131.612 1.00 23.37  ? 253 GLN E C   1 
ATOM   5115 O O   . GLN C 1 182 ? 108.302 124.233 132.270 1.00 23.37  ? 253 GLN E O   1 
ATOM   5116 C CB  . GLN C 1 182 ? 105.380 124.056 133.110 1.00 23.37  ? 253 GLN E CB  1 
ATOM   5117 C CG  . GLN C 1 182 ? 104.741 125.144 132.261 1.00 23.37  ? 253 GLN E CG  1 
ATOM   5118 C CD  . GLN C 1 182 ? 103.887 126.094 133.078 1.00 23.37  ? 253 GLN E CD  1 
ATOM   5119 O OE1 . GLN C 1 182 ? 103.789 125.966 134.298 1.00 23.37  ? 253 GLN E OE1 1 
ATOM   5120 N NE2 . GLN C 1 182 ? 103.263 127.054 132.406 1.00 23.37  ? 253 GLN E NE2 1 
ATOM   5121 N N   . TRP C 1 183 ? 107.296 123.854 130.286 1.00 24.53  ? 254 TRP E N   1 
ATOM   5122 C CA  . TRP C 1 183 ? 108.353 124.450 129.481 1.00 24.53  ? 254 TRP E CA  1 
ATOM   5123 C C   . TRP C 1 183 ? 107.805 125.626 128.685 1.00 24.53  ? 254 TRP E C   1 
ATOM   5124 O O   . TRP C 1 183 ? 106.709 125.551 128.119 1.00 24.53  ? 254 TRP E O   1 
ATOM   5125 C CB  . TRP C 1 183 ? 108.976 123.417 128.534 1.00 24.53  ? 254 TRP E CB  1 
ATOM   5126 C CG  . TRP C 1 183 ? 107.993 122.771 127.607 1.00 24.53  ? 254 TRP E CG  1 
ATOM   5127 C CD1 . TRP C 1 183 ? 107.195 121.698 127.876 1.00 24.53  ? 254 TRP E CD1 1 
ATOM   5128 C CD2 . TRP C 1 183 ? 107.707 123.155 126.256 1.00 24.53  ? 254 TRP E CD2 1 
ATOM   5129 N NE1 . TRP C 1 183 ? 106.428 121.391 126.778 1.00 24.53  ? 254 TRP E NE1 1 
ATOM   5130 C CE2 . TRP C 1 183 ? 106.724 122.271 125.770 1.00 24.53  ? 254 TRP E CE2 1 
ATOM   5131 C CE3 . TRP C 1 183 ? 108.186 124.161 125.412 1.00 24.53  ? 254 TRP E CE3 1 
ATOM   5132 C CZ2 . TRP C 1 183 ? 106.211 122.362 124.478 1.00 24.53  ? 254 TRP E CZ2 1 
ATOM   5133 C CZ3 . TRP C 1 183 ? 107.675 124.250 124.129 1.00 24.53  ? 254 TRP E CZ3 1 
ATOM   5134 C CH2 . TRP C 1 183 ? 106.698 123.356 123.675 1.00 24.53  ? 254 TRP E CH2 1 
ATOM   5135 N N   . TYR C 1 184 ? 108.575 126.711 128.647 1.00 22.35  ? 255 TYR E N   1 
ATOM   5136 C CA  . TYR C 1 184 ? 108.196 127.918 127.929 1.00 22.35  ? 255 TYR E CA  1 
ATOM   5137 C C   . TYR C 1 184 ? 109.365 128.417 127.091 1.00 22.35  ? 255 TYR E C   1 
ATOM   5138 O O   . TYR C 1 184 ? 110.534 128.222 127.439 1.00 22.35  ? 255 TYR E O   1 
ATOM   5139 C CB  . TYR C 1 184 ? 107.727 129.025 128.889 1.00 22.35  ? 255 TYR E CB  1 
ATOM   5140 C CG  . TYR C 1 184 ? 108.793 129.528 129.838 1.00 22.35  ? 255 TYR E CG  1 
ATOM   5141 C CD1 . TYR C 1 184 ? 109.050 128.873 131.035 1.00 22.35  ? 255 TYR E CD1 1 
ATOM   5142 C CD2 . TYR C 1 184 ? 109.533 130.666 129.542 1.00 22.35  ? 255 TYR E CD2 1 
ATOM   5143 C CE1 . TYR C 1 184 ? 110.020 129.331 131.907 1.00 22.35  ? 255 TYR E CE1 1 
ATOM   5144 C CE2 . TYR C 1 184 ? 110.505 131.131 130.407 1.00 22.35  ? 255 TYR E CE2 1 
ATOM   5145 C CZ  . TYR C 1 184 ? 110.744 130.460 131.588 1.00 22.35  ? 255 TYR E CZ  1 
ATOM   5146 O OH  . TYR C 1 184 ? 111.711 130.921 132.452 1.00 22.35  ? 255 TYR E OH  1 
ATOM   5147 N N   . THR C 1 185 ? 109.033 129.076 125.986 1.00 22.38  ? 256 THR E N   1 
ATOM   5148 C CA  . THR C 1 185 ? 110.011 129.580 125.034 1.00 22.38  ? 256 THR E CA  1 
ATOM   5149 C C   . THR C 1 185 ? 110.191 131.087 125.182 1.00 22.38  ? 256 THR E C   1 
ATOM   5150 O O   . THR C 1 185 ? 109.331 131.795 125.712 1.00 22.38  ? 256 THR E O   1 
ATOM   5151 C CB  . THR C 1 185 ? 109.592 129.246 123.600 1.00 22.38  ? 256 THR E CB  1 
ATOM   5152 O OG1 . THR C 1 185 ? 110.501 129.862 122.679 1.00 22.38  ? 256 THR E OG1 1 
ATOM   5153 C CG2 . THR C 1 185 ? 108.182 129.748 123.326 1.00 22.38  ? 256 THR E CG2 1 
ATOM   5154 N N   . LYS C 1 186 ? 111.335 131.570 124.702 1.00 21.27  ? 257 LYS E N   1 
ATOM   5155 C CA  . LYS C 1 186 ? 111.662 132.987 124.752 1.00 21.27  ? 257 LYS E CA  1 
ATOM   5156 C C   . LYS C 1 186 ? 112.567 133.326 123.577 1.00 21.27  ? 257 LYS E C   1 
ATOM   5157 O O   . LYS C 1 186 ? 113.420 132.523 123.189 1.00 21.27  ? 257 LYS E O   1 
ATOM   5158 C CB  . LYS C 1 186 ? 112.343 133.351 126.078 1.00 21.27  ? 257 LYS E CB  1 
ATOM   5159 C CG  . LYS C 1 186 ? 112.693 134.824 126.228 1.00 21.27  ? 257 LYS E CG  1 
ATOM   5160 C CD  . LYS C 1 186 ? 111.454 135.700 126.152 1.00 21.27  ? 257 LYS E CD  1 
ATOM   5161 C CE  . LYS C 1 186 ? 111.802 137.166 126.351 1.00 21.27  ? 257 LYS E CE  1 
ATOM   5162 N NZ  . LYS C 1 186 ? 112.774 137.650 125.332 1.00 21.27  ? 257 LYS E NZ  1 
ATOM   5163 N N   . HIS C 1 187 ? 112.369 134.513 123.012 1.00 22.95  ? 258 HIS E N   1 
ATOM   5164 C CA  . HIS C 1 187 ? 113.167 135.004 121.900 1.00 22.95  ? 258 HIS E CA  1 
ATOM   5165 C C   . HIS C 1 187 ? 114.134 136.080 122.379 1.00 22.95  ? 258 HIS E C   1 
ATOM   5166 O O   . HIS C 1 187 ? 113.937 136.704 123.425 1.00 22.95  ? 258 HIS E O   1 
ATOM   5167 C CB  . HIS C 1 187 ? 112.274 135.558 120.784 1.00 22.95  ? 258 HIS E CB  1 
ATOM   5168 C CG  . HIS C 1 187 ? 111.381 134.532 120.159 1.00 22.95  ? 258 HIS E CG  1 
ATOM   5169 N ND1 . HIS C 1 187 ? 111.764 133.774 119.074 1.00 22.95  ? 258 HIS E ND1 1 
ATOM   5170 C CD2 . HIS C 1 187 ? 110.123 134.138 120.468 1.00 22.95  ? 258 HIS E CD2 1 
ATOM   5171 C CE1 . HIS C 1 187 ? 110.780 132.957 118.740 1.00 22.95  ? 258 HIS E CE1 1 
ATOM   5172 N NE2 . HIS C 1 187 ? 109.773 133.158 119.571 1.00 22.95  ? 258 HIS E NE2 1 
ATOM   5173 N N   . HIS C 1 188 ? 115.190 136.290 121.593 1.00 19.12  ? 259 HIS E N   1 
ATOM   5174 C CA  . HIS C 1 188 ? 116.209 137.272 121.940 1.00 19.12  ? 259 HIS E CA  1 
ATOM   5175 C C   . HIS C 1 188 ? 116.482 138.214 120.774 1.00 19.12  ? 259 HIS E C   1 
ATOM   5176 O O   . HIS C 1 188 ? 115.773 138.184 119.763 1.00 19.12  ? 259 HIS E O   1 
ATOM   5177 C CB  . HIS C 1 188 ? 117.501 136.574 122.368 1.00 19.12  ? 259 HIS E CB  1 
ATOM   5178 C CG  . HIS C 1 188 ? 117.314 135.586 123.477 1.00 19.12  ? 259 HIS E CG  1 
ATOM   5179 N ND1 . HIS C 1 188 ? 117.010 135.963 124.767 1.00 19.12  ? 259 HIS E ND1 1 
ATOM   5180 C CD2 . HIS C 1 188 ? 117.390 134.234 123.488 1.00 19.12  ? 259 HIS E CD2 1 
ATOM   5181 C CE1 . HIS C 1 188 ? 116.904 134.886 125.524 1.00 19.12  ? 259 HIS E CE1 1 
ATOM   5182 N NE2 . HIS C 1 188 ? 117.131 133.824 124.773 1.00 19.12  ? 259 HIS E NE2 1 
ATOM   5183 N N   . ASN C 1 189 ? 117.508 139.051 120.907 1.00 20.49  ? 260 ASN E N   1 
ATOM   5184 C CA  . ASN C 1 189 ? 117.881 140.002 119.869 1.00 20.49  ? 260 ASN E CA  1 
ATOM   5185 C C   . ASN C 1 189 ? 118.894 139.437 118.882 1.00 20.49  ? 260 ASN E C   1 
ATOM   5186 O O   . ASN C 1 189 ? 119.296 140.147 117.955 1.00 20.49  ? 260 ASN E O   1 
ATOM   5187 C CB  . ASN C 1 189 ? 118.439 141.281 120.501 1.00 20.49  ? 260 ASN E CB  1 
ATOM   5188 C CG  . ASN C 1 189 ? 117.438 141.965 121.412 1.00 20.49  ? 260 ASN E CG  1 
ATOM   5189 O OD1 . ASN C 1 189 ? 116.228 141.874 121.203 1.00 20.49  ? 260 ASN E OD1 1 
ATOM   5190 N ND2 . ASN C 1 189 ? 117.939 142.656 122.429 1.00 20.49  ? 260 ASN E ND2 1 
ATOM   5191 N N   . ASN C 1 190 ? 119.318 138.184 119.058 1.00 17.95  ? 261 ASN E N   1 
ATOM   5192 C CA  . ASN C 1 190 ? 120.258 137.538 118.151 1.00 17.95  ? 261 ASN E CA  1 
ATOM   5193 C C   . ASN C 1 190 ? 119.613 136.401 117.366 1.00 17.95  ? 261 ASN E C   1 
ATOM   5194 O O   . ASN C 1 190 ? 120.313 135.484 116.922 1.00 17.95  ? 261 ASN E O   1 
ATOM   5195 C CB  . ASN C 1 190 ? 121.478 137.031 118.923 1.00 17.95  ? 261 ASN E CB  1 
ATOM   5196 C CG  . ASN C 1 190 ? 121.101 136.221 120.150 1.00 17.95  ? 261 ASN E CG  1 
ATOM   5197 O OD1 . ASN C 1 190 ? 119.947 135.832 120.322 1.00 17.95  ? 261 ASN E OD1 1 
ATOM   5198 N ND2 . ASN C 1 190 ? 122.080 135.962 121.011 1.00 17.95  ? 261 ASN E ND2 1 
ATOM   5199 N N   . ALA C 1 191 ? 118.290 136.448 117.187 1.00 14.52  ? 262 ALA E N   1 
ATOM   5200 C CA  . ALA C 1 191 ? 117.544 135.433 116.438 1.00 14.52  ? 262 ALA E CA  1 
ATOM   5201 C C   . ALA C 1 191 ? 117.770 134.034 117.008 1.00 14.52  ? 262 ALA E C   1 
ATOM   5202 O O   . ALA C 1 191 ? 117.918 133.058 116.269 1.00 14.52  ? 262 ALA E O   1 
ATOM   5203 C CB  . ALA C 1 191 ? 117.891 135.478 114.948 1.00 14.52  ? 262 ALA E CB  1 
ATOM   5204 N N   . THR C 1 192 ? 117.794 133.935 118.334 1.00 16.45  ? 263 THR E N   1 
ATOM   5205 C CA  . THR C 1 192 ? 117.964 132.667 119.026 1.00 16.45  ? 263 THR E CA  1 
ATOM   5206 C C   . THR C 1 192 ? 116.771 132.412 119.937 1.00 16.45  ? 263 THR E C   1 
ATOM   5207 O O   . THR C 1 192 ? 116.192 133.343 120.506 1.00 16.45  ? 263 THR E O   1 
ATOM   5208 C CB  . THR C 1 192 ? 119.258 132.641 119.850 1.00 16.45  ? 263 THR E CB  1 
ATOM   5209 O OG1 . THR C 1 192 ? 119.229 133.693 120.822 1.00 16.45  ? 263 THR E OG1 1 
ATOM   5210 C CG2 . THR C 1 192 ? 120.469 132.820 118.947 1.00 16.45  ? 263 THR E CG2 1 
ATOM   5211 N N   . THR C 1 193 ? 116.410 131.140 120.070 1.00 17.69  ? 264 THR E N   1 
ATOM   5212 C CA  . THR C 1 193 ? 115.281 130.716 120.886 1.00 17.69  ? 264 THR E CA  1 
ATOM   5213 C C   . THR C 1 193 ? 115.790 129.944 122.095 1.00 17.69  ? 264 THR E C   1 
ATOM   5214 O O   . THR C 1 193 ? 116.572 128.998 121.948 1.00 17.69  ? 264 THR E O   1 
ATOM   5215 C CB  . THR C 1 193 ? 114.315 129.848 120.074 1.00 17.69  ? 264 THR E CB  1 
ATOM   5216 O OG1 . THR C 1 193 ? 113.772 130.617 118.993 1.00 17.69  ? 264 THR E OG1 1 
ATOM   5217 C CG2 . THR C 1 193 ? 113.182 129.343 120.952 1.00 17.69  ? 264 THR E CG2 1 
ATOM   5218 N N   . SER C 1 194 ? 115.349 130.348 123.284 1.00 19.71  ? 265 SER E N   1 
ATOM   5219 C CA  . SER C 1 194 ? 115.727 129.696 124.530 1.00 19.71  ? 265 SER E CA  1 
ATOM   5220 C C   . SER C 1 194 ? 114.493 129.070 125.162 1.00 19.71  ? 265 SER E C   1 
ATOM   5221 O O   . SER C 1 194 ? 113.471 129.741 125.333 1.00 19.71  ? 265 SER E O   1 
ATOM   5222 C CB  . SER C 1 194 ? 116.375 130.688 125.500 1.00 19.71  ? 265 SER E CB  1 
ATOM   5223 O OG  . SER C 1 194 ? 115.487 131.745 125.817 1.00 19.71  ? 265 SER E OG  1 
ATOM   5224 N N   . ILE C 1 195 ? 114.593 127.793 125.514 1.00 18.43  ? 266 ILE E N   1 
ATOM   5225 C CA  . ILE C 1 195 ? 113.492 127.046 126.113 1.00 18.43  ? 266 ILE E CA  1 
ATOM   5226 C C   . ILE C 1 195 ? 113.866 126.702 127.547 1.00 18.43  ? 266 ILE E C   1 
ATOM   5227 O O   . ILE C 1 195 ? 114.914 126.092 127.793 1.00 18.43  ? 266 ILE E O   1 
ATOM   5228 C CB  . ILE C 1 195 ? 113.166 125.777 125.307 1.00 18.43  ? 266 ILE E CB  1 
ATOM   5229 C CG1 . ILE C 1 195 ? 112.786 126.140 123.870 1.00 18.43  ? 266 ILE E CG1 1 
ATOM   5230 C CG2 . ILE C 1 195 ? 112.046 124.994 125.977 1.00 18.43  ? 266 ILE E CG2 1 
ATOM   5231 C CD1 . ILE C 1 195 ? 112.465 124.943 123.002 1.00 18.43  ? 266 ILE E CD1 1 
ATOM   5232 N N   . THR C 1 196 ? 113.010 127.090 128.489 1.00 18.68  ? 267 THR E N   1 
ATOM   5233 C CA  . THR C 1 196 ? 113.221 126.828 129.906 1.00 18.68  ? 267 THR E CA  1 
ATOM   5234 C C   . THR C 1 196 ? 112.115 125.916 130.412 1.00 18.68  ? 267 THR E C   1 
ATOM   5235 O O   . THR C 1 196 ? 110.930 126.230 130.260 1.00 18.68  ? 267 THR E O   1 
ATOM   5236 C CB  . THR C 1 196 ? 113.238 128.128 130.717 1.00 18.68  ? 267 THR E CB  1 
ATOM   5237 O OG1 . THR C 1 196 ? 114.217 129.022 130.177 1.00 18.68  ? 267 THR E OG1 1 
ATOM   5238 C CG2 . THR C 1 196 ? 113.569 127.842 132.175 1.00 18.68  ? 267 THR E CG2 1 
ATOM   5239 N N   . SER C 1 197 ? 112.502 124.792 131.012 1.00 17.76  ? 268 SER E N   1 
ATOM   5240 C CA  . SER C 1 197 ? 111.562 123.824 131.559 1.00 17.76  ? 268 SER E CA  1 
ATOM   5241 C C   . SER C 1 197 ? 111.776 123.714 133.061 1.00 17.76  ? 268 SER E C   1 
ATOM   5242 O O   . SER C 1 197 ? 112.901 123.482 133.517 1.00 17.76  ? 268 SER E O   1 
ATOM   5243 C CB  . SER C 1 197 ? 111.731 122.455 130.894 1.00 17.76  ? 268 SER E CB  1 
ATOM   5244 O OG  . SER C 1 197 ? 110.791 121.524 131.401 1.00 17.76  ? 268 SER E OG  1 
ATOM   5245 N N   . ILE C 1 198 ? 110.697 123.873 133.823 1.00 17.67  ? 269 ILE E N   1 
ATOM   5246 C CA  . ILE C 1 198 ? 110.734 123.829 135.279 1.00 17.67  ? 269 ILE E CA  1 
ATOM   5247 C C   . ILE C 1 198 ? 109.895 122.649 135.749 1.00 17.67  ? 269 ILE E C   1 
ATOM   5248 O O   . ILE C 1 198 ? 108.776 122.439 135.262 1.00 17.67  ? 269 ILE E O   1 
ATOM   5249 C CB  . ILE C 1 198 ? 110.233 125.146 135.902 1.00 17.67  ? 269 ILE E CB  1 
ATOM   5250 C CG1 . ILE C 1 198 ? 108.907 125.575 135.268 1.00 17.67  ? 269 ILE E CG1 1 
ATOM   5251 C CG2 . ILE C 1 198 ? 111.279 126.240 135.748 1.00 17.67  ? 269 ILE E CG2 1 
ATOM   5252 C CD1 . ILE C 1 198 ? 108.343 126.858 135.839 1.00 17.67  ? 269 ILE E CD1 1 
ATOM   5253 N N   . LEU C 1 199 ? 110.445 121.873 136.681 1.00 17.62  ? 270 LEU E N   1 
ATOM   5254 C CA  . LEU C 1 199 ? 109.755 120.725 137.261 1.00 17.62  ? 270 LEU E CA  1 
ATOM   5255 C C   . LEU C 1 199 ? 109.770 120.871 138.776 1.00 17.62  ? 270 LEU E C   1 
ATOM   5256 O O   . LEU C 1 199 ? 110.860 120.982 139.374 1.00 17.62  ? 270 LEU E O   1 
ATOM   5257 C CB  . LEU C 1 199 ? 110.414 119.409 136.839 1.00 17.62  ? 270 LEU E CB  1 
ATOM   5258 C CG  . LEU C 1 199 ? 109.957 118.162 137.600 1.00 17.62  ? 270 LEU E CG  1 
ATOM   5259 C CD1 . LEU C 1 199 ? 108.478 117.887 137.366 1.00 17.62  ? 270 LEU E CD1 1 
ATOM   5260 C CD2 . LEU C 1 199 ? 110.799 116.953 137.219 1.00 17.62  ? 270 LEU E CD2 1 
ATOM   5261 N N   . PRO C 1 200 ? 108.613 120.900 139.436 1.00 17.56  ? 271 PRO E N   1 
ATOM   5262 C CA  . PRO C 1 200 ? 108.606 120.906 140.903 1.00 17.56  ? 271 PRO E CA  1 
ATOM   5263 C C   . PRO C 1 200 ? 109.230 119.633 141.457 1.00 17.56  ? 271 PRO E C   1 
ATOM   5264 O O   . PRO C 1 200 ? 109.083 118.549 140.890 1.00 17.56  ? 271 PRO E O   1 
ATOM   5265 C CB  . PRO C 1 200 ? 107.116 121.004 141.252 1.00 17.56  ? 271 PRO E CB  1 
ATOM   5266 C CG  . PRO C 1 200 ? 106.475 121.583 140.031 1.00 17.56  ? 271 PRO E CG  1 
ATOM   5267 C CD  . PRO C 1 200 ? 107.260 121.044 138.874 1.00 17.56  ? 271 PRO E CD  1 
ATOM   5268 N N   . VAL C 1 201 ? 109.933 119.776 142.579 1.00 17.13  ? 272 VAL E N   1 
ATOM   5269 C CA  . VAL C 1 201 ? 110.609 118.671 143.238 1.00 17.13  ? 272 VAL E CA  1 
ATOM   5270 C C   . VAL C 1 201 ? 110.189 118.648 144.705 1.00 17.13  ? 272 VAL E C   1 
ATOM   5271 O O   . VAL C 1 201 ? 109.361 119.442 145.148 1.00 17.13  ? 272 VAL E O   1 
ATOM   5272 C CB  . VAL C 1 201 ? 112.144 118.759 143.104 1.00 17.13  ? 272 VAL E CB  1 
ATOM   5273 C CG1 . VAL C 1 201 ? 112.556 118.685 141.642 1.00 17.13  ? 272 VAL E CG1 1 
ATOM   5274 C CG2 . VAL C 1 201 ? 112.662 120.035 143.745 1.00 17.13  ? 272 VAL E CG2 1 
ATOM   5275 N N   . VAL C 1 202 ? 110.770 117.715 145.454 1.00 19.89  ? 273 VAL E N   1 
ATOM   5276 C CA  . VAL C 1 202 ? 110.485 117.539 146.872 1.00 19.89  ? 273 VAL E CA  1 
ATOM   5277 C C   . VAL C 1 202 ? 111.790 117.651 147.646 1.00 19.89  ? 273 VAL E C   1 
ATOM   5278 O O   . VAL C 1 202 ? 112.810 117.078 147.246 1.00 19.89  ? 273 VAL E O   1 
ATOM   5279 C CB  . VAL C 1 202 ? 109.796 116.186 147.153 1.00 19.89  ? 273 VAL E CB  1 
ATOM   5280 C CG1 . VAL C 1 202 ? 109.466 116.050 148.632 1.00 19.89  ? 273 VAL E CG1 1 
ATOM   5281 C CG2 . VAL C 1 202 ? 108.540 116.041 146.307 1.00 19.89  ? 273 VAL E CG2 1 
ATOM   5282 N N   . ALA C 1 203 ? 111.757 118.400 148.751 1.00 21.00  ? 274 ALA E N   1 
ATOM   5283 C CA  . ALA C 1 203 ? 112.951 118.560 149.575 1.00 21.00  ? 274 ALA E CA  1 
ATOM   5284 C C   . ALA C 1 203 ? 113.406 117.226 150.154 1.00 21.00  ? 274 ALA E C   1 
ATOM   5285 O O   . ALA C 1 203 ? 114.611 116.958 150.242 1.00 21.00  ? 274 ALA E O   1 
ATOM   5286 C CB  . ALA C 1 203 ? 112.687 119.569 150.693 1.00 21.00  ? 274 ALA E CB  1 
ATOM   5287 N N   . LYS C 1 204 ? 112.457 116.380 150.562 1.00 21.77  ? 275 LYS E N   1 
ATOM   5288 C CA  . LYS C 1 204 ? 112.812 115.057 151.065 1.00 21.77  ? 275 LYS E CA  1 
ATOM   5289 C C   . LYS C 1 204 ? 113.486 114.220 149.985 1.00 21.77  ? 275 LYS E C   1 
ATOM   5290 O O   . LYS C 1 204 ? 114.466 113.516 150.256 1.00 21.77  ? 275 LYS E O   1 
ATOM   5291 C CB  . LYS C 1 204 ? 111.568 114.346 151.598 1.00 21.77  ? 275 LYS E CB  1 
ATOM   5292 C CG  . LYS C 1 204 ? 110.920 115.033 152.789 1.00 21.77  ? 275 LYS E CG  1 
ATOM   5293 C CD  . LYS C 1 204 ? 111.852 115.054 153.990 1.00 21.77  ? 275 LYS E CD  1 
ATOM   5294 C CE  . LYS C 1 204 ? 112.203 113.645 154.442 1.00 21.77  ? 275 LYS E CE  1 
ATOM   5295 N NZ  . LYS C 1 204 ? 110.993 112.865 154.823 1.00 21.77  ? 275 LYS E NZ  1 
ATOM   5296 N N   . ASP C 1 205 ? 112.976 114.284 148.753 1.00 19.91  ? 276 ASP E N   1 
ATOM   5297 C CA  . ASP C 1 205 ? 113.605 113.555 147.656 1.00 19.91  ? 276 ASP E CA  1 
ATOM   5298 C C   . ASP C 1 205 ? 115.017 114.064 147.395 1.00 19.91  ? 276 ASP E C   1 
ATOM   5299 O O   . ASP C 1 205 ? 115.933 113.273 147.141 1.00 19.91  ? 276 ASP E O   1 
ATOM   5300 C CB  . ASP C 1 205 ? 112.751 113.669 146.393 1.00 19.91  ? 276 ASP E CB  1 
ATOM   5301 C CG  . ASP C 1 205 ? 111.361 113.094 146.575 1.00 19.91  ? 276 ASP E CG  1 
ATOM   5302 O OD1 . ASP C 1 205 ? 111.083 112.538 147.658 1.00 19.91  ? 276 ASP E OD1 1 
ATOM   5303 O OD2 . ASP C 1 205 ? 110.545 113.202 145.636 1.00 19.91  ? 276 ASP E OD2 1 
ATOM   5304 N N   . TRP C 1 206 ? 115.209 115.384 147.447 1.00 18.62  ? 277 TRP E N   1 
ATOM   5305 C CA  . TRP C 1 206 ? 116.537 115.949 147.225 1.00 18.62  ? 277 TRP E CA  1 
ATOM   5306 C C   . TRP C 1 206 ? 117.510 115.533 148.322 1.00 18.62  ? 277 TRP E C   1 
ATOM   5307 O O   . TRP C 1 206 ? 118.665 115.197 148.038 1.00 18.62  ? 277 TRP E O   1 
ATOM   5308 C CB  . TRP C 1 206 ? 116.449 117.472 147.134 1.00 18.62  ? 277 TRP E CB  1 
ATOM   5309 C CG  . TRP C 1 206 ? 117.743 118.126 146.754 1.00 18.62  ? 277 TRP E CG  1 
ATOM   5310 C CD1 . TRP C 1 206 ? 118.698 118.608 147.601 1.00 18.62  ? 277 TRP E CD1 1 
ATOM   5311 C CD2 . TRP C 1 206 ? 118.225 118.368 145.427 1.00 18.62  ? 277 TRP E CD2 1 
ATOM   5312 N NE1 . TRP C 1 206 ? 119.744 119.136 146.884 1.00 18.62  ? 277 TRP E NE1 1 
ATOM   5313 C CE2 . TRP C 1 206 ? 119.478 119.001 145.547 1.00 18.62  ? 277 TRP E CE2 1 
ATOM   5314 C CE3 . TRP C 1 206 ? 117.718 118.111 144.149 1.00 18.62  ? 277 TRP E CE3 1 
ATOM   5315 C CZ2 . TRP C 1 206 ? 120.231 119.381 144.438 1.00 18.62  ? 277 TRP E CZ2 1 
ATOM   5316 C CZ3 . TRP C 1 206 ? 118.468 118.489 143.050 1.00 18.62  ? 277 TRP E CZ3 1 
ATOM   5317 C CH2 . TRP C 1 206 ? 119.710 119.117 143.201 1.00 18.62  ? 277 TRP E CH2 1 
ATOM   5318 N N   . ILE C 1 207 ? 117.065 115.548 149.581 1.00 21.27  ? 278 ILE E N   1 
ATOM   5319 C CA  . ILE C 1 207 ? 117.955 115.188 150.681 1.00 21.27  ? 278 ILE E CA  1 
ATOM   5320 C C   . ILE C 1 207 ? 118.190 113.684 150.759 1.00 21.27  ? 278 ILE E C   1 
ATOM   5321 O O   . ILE C 1 207 ? 119.199 113.252 151.333 1.00 21.27  ? 278 ILE E O   1 
ATOM   5322 C CB  . ILE C 1 207 ? 117.412 115.725 152.018 1.00 21.27  ? 278 ILE E CB  1 
ATOM   5323 C CG1 . ILE C 1 207 ? 118.522 115.776 153.070 1.00 21.27  ? 278 ILE E CG1 1 
ATOM   5324 C CG2 . ILE C 1 207 ? 116.254 114.875 152.517 1.00 21.27  ? 278 ILE E CG2 1 
ATOM   5325 C CD1 . ILE C 1 207 ? 119.686 116.664 152.687 1.00 21.27  ? 278 ILE E CD1 1 
ATOM   5326 N N   . GLU C 1 208 ? 117.299 112.870 150.190 1.00 22.01  ? 279 GLU E N   1 
ATOM   5327 C CA  . GLU C 1 208 ? 117.501 111.427 150.165 1.00 22.01  ? 279 GLU E CA  1 
ATOM   5328 C C   . GLU C 1 208 ? 118.505 110.984 149.110 1.00 22.01  ? 279 GLU E C   1 
ATOM   5329 O O   . GLU C 1 208 ? 118.903 109.814 149.112 1.00 22.01  ? 279 GLU E O   1 
ATOM   5330 C CB  . GLU C 1 208 ? 116.168 110.709 149.934 1.00 22.01  ? 279 GLU E CB  1 
ATOM   5331 C CG  . GLU C 1 208 ? 115.297 110.583 151.176 1.00 22.01  ? 279 GLU E CG  1 
ATOM   5332 C CD  . GLU C 1 208 ? 115.831 109.567 152.168 1.00 22.01  ? 279 GLU E CD  1 
ATOM   5333 O OE1 . GLU C 1 208 ? 116.693 108.749 151.782 1.00 22.01  ? 279 GLU E OE1 1 
ATOM   5334 O OE2 . GLU C 1 208 ? 115.387 109.585 153.335 1.00 22.01  ? 279 GLU E OE2 1 
ATOM   5335 N N   . GLY C 1 209 ? 118.922 111.877 148.218 1.00 21.22  ? 280 GLY E N   1 
ATOM   5336 C CA  . GLY C 1 209 ? 119.886 111.546 147.191 1.00 21.22  ? 280 GLY E CA  1 
ATOM   5337 C C   . GLY C 1 209 ? 119.316 111.257 145.821 1.00 21.22  ? 280 GLY E C   1 
ATOM   5338 O O   . GLY C 1 209 ? 120.073 110.849 144.933 1.00 21.22  ? 280 GLY E O   1 
ATOM   5339 N N   . TYR C 1 210 ? 118.016 111.449 145.619 1.00 20.45  ? 281 TYR E N   1 
ATOM   5340 C CA  . TYR C 1 210 ? 117.422 111.221 144.310 1.00 20.45  ? 281 TYR E CA  1 
ATOM   5341 C C   . TYR C 1 210 ? 117.868 112.293 143.322 1.00 20.45  ? 281 TYR E C   1 
ATOM   5342 O O   . TYR C 1 210 ? 118.184 113.426 143.696 1.00 20.45  ? 281 TYR E O   1 
ATOM   5343 C CB  . TYR C 1 210 ? 115.897 111.201 144.407 1.00 20.45  ? 281 TYR E CB  1 
ATOM   5344 C CG  . TYR C 1 210 ? 115.346 110.046 145.212 1.00 20.45  ? 281 TYR E CG  1 
ATOM   5345 C CD1 . TYR C 1 210 ? 115.233 108.779 144.656 1.00 20.45  ? 281 TYR E CD1 1 
ATOM   5346 C CD2 . TYR C 1 210 ? 114.934 110.223 146.526 1.00 20.45  ? 281 TYR E CD2 1 
ATOM   5347 C CE1 . TYR C 1 210 ? 114.730 107.719 145.387 1.00 20.45  ? 281 TYR E CE1 1 
ATOM   5348 C CE2 . TYR C 1 210 ? 114.428 109.170 147.265 1.00 20.45  ? 281 TYR E CE2 1 
ATOM   5349 C CZ  . TYR C 1 210 ? 114.329 107.921 146.690 1.00 20.45  ? 281 TYR E CZ  1 
ATOM   5350 O OH  . TYR C 1 210 ? 113.826 106.869 147.422 1.00 20.45  ? 281 TYR E OH  1 
ATOM   5351 N N   . GLY C 1 211 ? 117.892 111.921 142.038 1.00 21.43  ? 282 GLY E N   1 
ATOM   5352 C CA  . GLY C 1 211 ? 118.306 112.825 140.990 1.00 21.43  ? 282 GLY E CA  1 
ATOM   5353 C C   . GLY C 1 211 ? 117.285 112.868 139.866 1.00 21.43  ? 282 GLY E C   1 
ATOM   5354 O O   . GLY C 1 211 ? 116.317 112.104 139.843 1.00 21.43  ? 282 GLY E O   1 
ATOM   5355 N N   . TYR C 1 212 ? 117.523 113.785 138.932 1.00 20.07  ? 283 TYR E N   1 
ATOM   5356 C CA  . TYR C 1 212 ? 116.652 113.979 137.783 1.00 20.07  ? 283 TYR E CA  1 
ATOM   5357 C C   . TYR C 1 212 ? 117.496 114.030 136.517 1.00 20.07  ? 283 TYR E C   1 
ATOM   5358 O O   . TYR C 1 212 ? 118.715 114.211 136.570 1.00 20.07  ? 283 TYR E O   1 
ATOM   5359 C CB  . TYR C 1 212 ? 115.814 115.259 137.921 1.00 20.07  ? 283 TYR E CB  1 
ATOM   5360 C CG  . TYR C 1 212 ? 114.859 115.239 139.095 1.00 20.07  ? 283 TYR E CG  1 
ATOM   5361 C CD1 . TYR C 1 212 ? 115.291 115.570 140.373 1.00 20.07  ? 283 TYR E CD1 1 
ATOM   5362 C CD2 . TYR C 1 212 ? 113.526 114.890 138.925 1.00 20.07  ? 283 TYR E CD2 1 
ATOM   5363 C CE1 . TYR C 1 212 ? 114.422 115.553 141.448 1.00 20.07  ? 283 TYR E CE1 1 
ATOM   5364 C CE2 . TYR C 1 212 ? 112.650 114.871 139.994 1.00 20.07  ? 283 TYR E CE2 1 
ATOM   5365 C CZ  . TYR C 1 212 ? 113.104 115.203 141.253 1.00 20.07  ? 283 TYR E CZ  1 
ATOM   5366 O OH  . TYR C 1 212 ? 112.235 115.185 142.320 1.00 20.07  ? 283 TYR E OH  1 
ATOM   5367 N N   . GLN C 1 213 ? 116.840 113.856 135.371 1.00 22.13  ? 284 GLN E N   1 
ATOM   5368 C CA  . GLN C 1 213 ? 117.533 113.819 134.086 1.00 22.13  ? 284 GLN E CA  1 
ATOM   5369 C C   . GLN C 1 213 ? 116.756 114.657 133.080 1.00 22.13  ? 284 GLN E C   1 
ATOM   5370 O O   . GLN C 1 213 ? 115.636 114.296 132.698 1.00 22.13  ? 284 GLN E O   1 
ATOM   5371 C CB  . GLN C 1 213 ? 117.694 112.382 133.590 1.00 22.13  ? 284 GLN E CB  1 
ATOM   5372 C CG  . GLN C 1 213 ? 118.547 112.245 132.341 1.00 22.13  ? 284 GLN E CG  1 
ATOM   5373 C CD  . GLN C 1 213 ? 118.733 110.800 131.919 1.00 22.13  ? 284 GLN E CD  1 
ATOM   5374 O OE1 . GLN C 1 213 ? 119.430 110.510 130.947 1.00 22.13  ? 284 GLN E OE1 1 
ATOM   5375 N NE2 . GLN C 1 213 ? 118.107 109.885 132.651 1.00 22.13  ? 284 GLN E NE2 1 
ATOM   5376 N N   . CYS C 1 214 ? 117.352 115.770 132.658 1.00 20.08  ? 285 CYS E N   1 
ATOM   5377 C CA  . CYS C 1 214 ? 116.814 116.608 131.596 1.00 20.08  ? 285 CYS E CA  1 
ATOM   5378 C C   . CYS C 1 214 ? 117.320 116.079 130.259 1.00 20.08  ? 285 CYS E C   1 
ATOM   5379 O O   . CYS C 1 214 ? 118.530 116.079 130.004 1.00 20.08  ? 285 CYS E O   1 
ATOM   5380 C CB  . CYS C 1 214 ? 117.233 118.065 131.801 1.00 20.08  ? 285 CYS E CB  1 
ATOM   5381 S SG  . CYS C 1 214 ? 116.778 119.205 130.468 1.00 20.08  ? 285 CYS E SG  1 
ATOM   5382 N N   . ILE C 1 215 ? 116.401 115.619 129.416 1.00 21.27  ? 286 ILE E N   1 
ATOM   5383 C CA  . ILE C 1 215 ? 116.736 115.024 128.126 1.00 21.27  ? 286 ILE E CA  1 
ATOM   5384 C C   . ILE C 1 215 ? 116.131 115.893 127.035 1.00 21.27  ? 286 ILE E C   1 
ATOM   5385 O O   . ILE C 1 215 ? 114.910 116.077 126.990 1.00 21.27  ? 286 ILE E O   1 
ATOM   5386 C CB  . ILE C 1 215 ? 116.230 113.577 128.015 1.00 21.27  ? 286 ILE E CB  1 
ATOM   5387 C CG1 . ILE C 1 215 ? 116.723 112.746 129.201 1.00 21.27  ? 286 ILE E CG1 1 
ATOM   5388 C CG2 . ILE C 1 215 ? 116.673 112.957 126.699 1.00 21.27  ? 286 ILE E CG2 1 
ATOM   5389 C CD1 . ILE C 1 215 ? 116.264 111.304 129.169 1.00 21.27  ? 286 ILE E CD1 1 
ATOM   5390 N N   . VAL C 1 216 ? 116.976 116.411 126.150 1.00 24.74  ? 287 VAL E N   1 
ATOM   5391 C CA  . VAL C 1 216 ? 116.551 117.299 125.074 1.00 24.74  ? 287 VAL E CA  1 
ATOM   5392 C C   . VAL C 1 216 ? 116.736 116.573 123.750 1.00 24.74  ? 287 VAL E C   1 
ATOM   5393 O O   . VAL C 1 216 ? 117.813 116.026 123.479 1.00 24.74  ? 287 VAL E O   1 
ATOM   5394 C CB  . VAL C 1 216 ? 117.335 118.622 125.093 1.00 24.74  ? 287 VAL E CB  1 
ATOM   5395 C CG1 . VAL C 1 216 ? 116.787 119.580 124.045 1.00 24.74  ? 287 VAL E CG1 1 
ATOM   5396 C CG2 . VAL C 1 216 ? 117.282 119.245 126.479 1.00 24.74  ? 287 VAL E CG2 1 
ATOM   5397 N N   . ASP C 1 217 ? 115.685 116.561 122.930 1.00 30.22  ? 288 ASP E N   1 
ATOM   5398 C CA  . ASP C 1 217 ? 115.719 115.916 121.625 1.00 30.22  ? 288 ASP E CA  1 
ATOM   5399 C C   . ASP C 1 217 ? 115.320 116.926 120.560 1.00 30.22  ? 288 ASP E C   1 
ATOM   5400 O O   . ASP C 1 217 ? 114.302 117.618 120.699 1.00 30.22  ? 288 ASP E O   1 
ATOM   5401 C CB  . ASP C 1 217 ? 114.795 114.694 121.585 1.00 30.22  ? 288 ASP E CB  1 
ATOM   5402 C CG  . ASP C 1 217 ? 115.047 113.810 120.378 1.00 30.22  ? 288 ASP E CG  1 
ATOM   5403 O OD1 . ASP C 1 217 ? 115.968 114.117 119.593 1.00 30.22  ? 288 ASP E OD1 1 
ATOM   5404 O OD2 . ASP C 1 217 ? 114.324 112.804 120.217 1.00 30.22  ? 288 ASP E OD2 1 
ATOM   5405 N N   . HIS C 1 218 ? 116.123 116.996 119.502 1.00 29.88  ? 289 HIS E N   1 
ATOM   5406 C CA  . HIS C 1 218 ? 116.008 117.921 118.388 1.00 29.88  ? 289 HIS E CA  1 
ATOM   5407 C C   . HIS C 1 218 ? 116.091 117.144 117.082 1.00 29.88  ? 289 HIS E C   1 
ATOM   5408 O O   . HIS C 1 218 ? 116.791 116.128 117.006 1.00 29.88  ? 289 HIS E O   1 
ATOM   5409 C CB  . HIS C 1 218 ? 117.128 118.972 118.446 1.00 29.88  ? 289 HIS E CB  1 
ATOM   5410 C CG  . HIS C 1 218 ? 116.962 120.106 117.483 1.00 29.88  ? 289 HIS E CG  1 
ATOM   5411 N ND1 . HIS C 1 218 ? 117.300 120.008 116.150 1.00 29.88  ? 289 HIS E ND1 1 
ATOM   5412 C CD2 . HIS C 1 218 ? 116.512 121.370 117.663 1.00 29.88  ? 289 HIS E CD2 1 
ATOM   5413 C CE1 . HIS C 1 218 ? 117.052 121.157 115.549 1.00 29.88  ? 289 HIS E CE1 1 
ATOM   5414 N NE2 . HIS C 1 218 ? 116.573 122.001 116.445 1.00 29.88  ? 289 HIS E NE2 1 
ATOM   5415 N N   . PRO C 1 219 ? 115.381 117.588 116.041 1.00 32.08  ? 290 PRO E N   1 
ATOM   5416 C CA  . PRO C 1 219 ? 115.396 116.841 114.771 1.00 32.08  ? 290 PRO E CA  1 
ATOM   5417 C C   . PRO C 1 219 ? 116.768 116.722 114.126 1.00 32.08  ? 290 PRO E C   1 
ATOM   5418 O O   . PRO C 1 219 ? 116.988 115.774 113.361 1.00 32.08  ? 290 PRO E O   1 
ATOM   5419 C CB  . PRO C 1 219 ? 114.434 117.644 113.884 1.00 32.08  ? 290 PRO E CB  1 
ATOM   5420 C CG  . PRO C 1 219 ? 113.520 118.314 114.842 1.00 32.08  ? 290 PRO E CG  1 
ATOM   5421 C CD  . PRO C 1 219 ? 114.354 118.644 116.046 1.00 32.08  ? 290 PRO E CD  1 
ATOM   5422 N N   . ASP C 1 220 ? 117.693 117.645 114.397 1.00 30.26  ? 291 ASP E N   1 
ATOM   5423 C CA  . ASP C 1 220 ? 118.993 117.609 113.732 1.00 30.26  ? 291 ASP E CA  1 
ATOM   5424 C C   . ASP C 1 220 ? 119.799 116.387 114.158 1.00 30.26  ? 291 ASP E C   1 
ATOM   5425 O O   . ASP C 1 220 ? 120.148 115.538 113.329 1.00 30.26  ? 291 ASP E O   1 
ATOM   5426 C CB  . ASP C 1 220 ? 119.768 118.896 114.020 1.00 30.26  ? 291 ASP E CB  1 
ATOM   5427 C CG  . ASP C 1 220 ? 119.209 120.093 113.276 1.00 30.26  ? 291 ASP E CG  1 
ATOM   5428 O OD1 . ASP C 1 220 ? 118.507 119.890 112.263 1.00 30.26  ? 291 ASP E OD1 1 
ATOM   5429 O OD2 . ASP C 1 220 ? 119.478 121.237 113.699 1.00 30.26  ? 291 ASP E OD2 1 
ATOM   5430 N N   . PHE C 1 221 ? 120.107 116.281 115.448 1.00 28.66  ? 292 PHE E N   1 
ATOM   5431 C CA  . PHE C 1 221 ? 120.898 115.165 115.949 1.00 28.66  ? 292 PHE E CA  1 
ATOM   5432 C C   . PHE C 1 221 ? 119.976 114.073 116.475 1.00 28.66  ? 292 PHE E C   1 
ATOM   5433 O O   . PHE C 1 221 ? 119.179 114.338 117.385 1.00 28.66  ? 292 PHE E O   1 
ATOM   5434 C CB  . PHE C 1 221 ? 121.862 115.622 117.037 1.00 28.66  ? 292 PHE E CB  1 
ATOM   5435 C CG  . PHE C 1 221 ? 121.257 116.563 118.047 1.00 28.66  ? 292 PHE E CG  1 
ATOM   5436 C CD1 . PHE C 1 221 ? 121.167 117.922 117.786 1.00 28.66  ? 292 PHE E CD1 1 
ATOM   5437 C CD2 . PHE C 1 221 ? 120.811 116.092 119.271 1.00 28.66  ? 292 PHE E CD2 1 
ATOM   5438 C CE1 . PHE C 1 221 ? 120.624 118.787 118.718 1.00 28.66  ? 292 PHE E CE1 1 
ATOM   5439 C CE2 . PHE C 1 221 ? 120.267 116.952 120.205 1.00 28.66  ? 292 PHE E CE2 1 
ATOM   5440 C CZ  . PHE C 1 221 ? 120.175 118.301 119.930 1.00 28.66  ? 292 PHE E CZ  1 
ATOM   5441 N N   . PRO C 1 222 ? 120.029 112.857 115.925 1.00 29.48  ? 293 PRO E N   1 
ATOM   5442 C CA  . PRO C 1 222 ? 119.126 111.796 116.403 1.00 29.48  ? 293 PRO E CA  1 
ATOM   5443 C C   . PRO C 1 222 ? 119.332 111.425 117.860 1.00 29.48  ? 293 PRO E C   1 
ATOM   5444 O O   . PRO C 1 222 ? 118.362 111.062 118.538 1.00 29.48  ? 293 PRO E O   1 
ATOM   5445 C CB  . PRO C 1 222 ? 119.447 110.621 115.469 1.00 29.48  ? 293 PRO E CB  1 
ATOM   5446 C CG  . PRO C 1 222 ? 120.840 110.884 114.996 1.00 29.48  ? 293 PRO E CG  1 
ATOM   5447 C CD  . PRO C 1 222 ? 120.950 112.376 114.882 1.00 29.48  ? 293 PRO E CD  1 
ATOM   5448 N N   . LYS C 1 223 ? 120.557 111.503 118.365 1.00 30.46  ? 294 LYS E N   1 
ATOM   5449 C CA  . LYS C 1 223 ? 120.829 111.108 119.741 1.00 30.46  ? 294 LYS E CA  1 
ATOM   5450 C C   . LYS C 1 223 ? 120.483 112.253 120.685 1.00 30.46  ? 294 LYS E C   1 
ATOM   5451 O O   . LYS C 1 223 ? 121.105 113.319 120.600 1.00 30.46  ? 294 LYS E O   1 
ATOM   5452 C CB  . LYS C 1 223 ? 122.291 110.716 119.904 1.00 30.46  ? 294 LYS E CB  1 
ATOM   5453 C CG  . LYS C 1 223 ? 122.785 109.708 118.877 1.00 30.46  ? 294 LYS E CG  1 
ATOM   5454 C CD  . LYS C 1 223 ? 122.006 108.405 118.952 1.00 30.46  ? 294 LYS E CD  1 
ATOM   5455 C CE  . LYS C 1 223 ? 122.216 107.709 120.287 1.00 30.46  ? 294 LYS E CE  1 
ATOM   5456 N NZ  . LYS C 1 223 ? 121.482 106.416 120.361 1.00 30.46  ? 294 LYS E NZ  1 
ATOM   5457 N N   . PRO C 1 224 ? 119.518 112.084 121.586 1.00 25.99  ? 295 PRO E N   1 
ATOM   5458 C CA  . PRO C 1 224 ? 119.174 113.170 122.509 1.00 25.99  ? 295 PRO E CA  1 
ATOM   5459 C C   . PRO C 1 224 ? 120.298 113.446 123.494 1.00 25.99  ? 295 PRO E C   1 
ATOM   5460 O O   . PRO C 1 224 ? 121.080 112.560 123.850 1.00 25.99  ? 295 PRO E O   1 
ATOM   5461 C CB  . PRO C 1 224 ? 117.924 112.644 123.223 1.00 25.99  ? 295 PRO E CB  1 
ATOM   5462 C CG  . PRO C 1 224 ? 118.049 111.159 123.142 1.00 25.99  ? 295 PRO E CG  1 
ATOM   5463 C CD  . PRO C 1 224 ? 118.707 110.877 121.820 1.00 25.99  ? 295 PRO E CD  1 
ATOM   5464 N N   . ILE C 1 225 ? 120.371 114.697 123.937 1.00 23.41  ? 296 ILE E N   1 
ATOM   5465 C CA  . ILE C 1 225 ? 121.380 115.122 124.900 1.00 23.41  ? 296 ILE E CA  1 
ATOM   5466 C C   . ILE C 1 225 ? 120.796 115.019 126.303 1.00 23.41  ? 296 ILE E C   1 
ATOM   5467 O O   . ILE C 1 225 ? 119.707 115.540 126.575 1.00 23.41  ? 296 ILE E O   1 
ATOM   5468 C CB  . ILE C 1 225 ? 121.864 116.551 124.599 1.00 23.41  ? 296 ILE E CB  1 
ATOM   5469 C CG1 . ILE C 1 225 ? 120.684 117.452 124.230 1.00 23.41  ? 296 ILE E CG1 1 
ATOM   5470 C CG2 . ILE C 1 225 ? 122.900 116.537 123.485 1.00 23.41  ? 296 ILE E CG2 1 
ATOM   5471 C CD1 . ILE C 1 225 ? 121.086 118.856 123.838 1.00 23.41  ? 296 ILE E CD1 1 
ATOM   5472 N N   . VAL C 1 226 ? 121.519 114.347 127.195 1.00 22.75  ? 297 VAL E N   1 
ATOM   5473 C CA  . VAL C 1 226 ? 121.047 114.060 128.543 1.00 22.75  ? 297 VAL E CA  1 
ATOM   5474 C C   . VAL C 1 226 ? 121.934 114.783 129.547 1.00 22.75  ? 297 VAL E C   1 
ATOM   5475 O O   . VAL C 1 226 ? 123.162 114.806 129.406 1.00 22.75  ? 297 VAL E O   1 
ATOM   5476 C CB  . VAL C 1 226 ? 121.020 112.541 128.824 1.00 22.75  ? 297 VAL E CB  1 
ATOM   5477 C CG1 . VAL C 1 226 ? 119.994 111.860 127.936 1.00 22.75  ? 297 VAL E CG1 1 
ATOM   5478 C CG2 . VAL C 1 226 ? 122.394 111.924 128.605 1.00 22.75  ? 297 VAL E CG2 1 
ATOM   5479 N N   . ARG C 1 227 ? 121.306 115.393 130.551 1.00 28.01  ? 298 ARG E N   1 
ATOM   5480 C CA  . ARG C 1 227 ? 122.011 116.043 131.649 1.00 28.01  ? 298 ARG E CA  1 
ATOM   5481 C C   . ARG C 1 227 ? 121.362 115.605 132.952 1.00 28.01  ? 298 ARG E C   1 
ATOM   5482 O O   . ARG C 1 227 ? 120.179 115.875 133.177 1.00 28.01  ? 298 ARG E O   1 
ATOM   5483 C CB  . ARG C 1 227 ? 121.971 117.569 131.511 1.00 28.01  ? 298 ARG E CB  1 
ATOM   5484 C CG  . ARG C 1 227 ? 122.555 118.095 130.208 1.00 28.01  ? 298 ARG E CG  1 
ATOM   5485 C CD  . ARG C 1 227 ? 124.053 117.848 130.129 1.00 28.01  ? 298 ARG E CD  1 
ATOM   5486 N NE  . ARG C 1 227 ? 124.793 118.684 131.065 1.00 28.01  ? 298 ARG E NE  1 
ATOM   5487 C CZ  . ARG C 1 227 ? 125.313 119.866 130.763 1.00 28.01  ? 298 ARG E CZ  1 
ATOM   5488 N NH1 . ARG C 1 227 ? 125.200 120.380 129.549 1.00 28.01  ? 298 ARG E NH1 1 
ATOM   5489 N NH2 . ARG C 1 227 ? 125.962 120.548 131.701 1.00 28.01  ? 298 ARG E NH2 1 
ATOM   5490 N N   . SER C 1 228 ? 122.129 114.937 133.807 1.00 30.13  ? 299 SER E N   1 
ATOM   5491 C CA  . SER C 1 228 ? 121.617 114.389 135.056 1.00 30.13  ? 299 SER E CA  1 
ATOM   5492 C C   . SER C 1 228 ? 122.112 115.222 136.230 1.00 30.13  ? 299 SER E C   1 
ATOM   5493 O O   . SER C 1 228 ? 123.304 115.537 136.316 1.00 30.13  ? 299 SER E O   1 
ATOM   5494 C CB  . SER C 1 228 ? 122.033 112.926 135.221 1.00 30.13  ? 299 SER E CB  1 
ATOM   5495 O OG  . SER C 1 228 ? 123.336 112.707 134.712 1.00 30.13  ? 299 SER E OG  1 
ATOM   5496 N N   . ILE C 1 229 ? 121.194 115.575 137.126 1.00 22.90  ? 300 ILE E N   1 
ATOM   5497 C CA  . ILE C 1 229 ? 121.486 116.403 138.290 1.00 22.90  ? 300 ILE E CA  1 
ATOM   5498 C C   . ILE C 1 229 ? 121.155 115.612 139.548 1.00 22.90  ? 300 ILE E C   1 
ATOM   5499 O O   . ILE C 1 229 ? 120.091 114.985 139.636 1.00 22.90  ? 300 ILE E O   1 
ATOM   5500 C CB  . ILE C 1 229 ? 120.710 117.735 138.254 1.00 22.90  ? 300 ILE E CB  1 
ATOM   5501 C CG1 . ILE C 1 229 ? 120.989 118.556 139.515 1.00 22.90  ? 300 ILE E CG1 1 
ATOM   5502 C CG2 . ILE C 1 229 ? 119.214 117.495 138.079 1.00 22.90  ? 300 ILE E CG2 1 
ATOM   5503 C CD1 . ILE C 1 229 ? 122.441 118.949 139.681 1.00 22.90  ? 300 ILE E CD1 1 
ATOM   5504 N N   . THR C 1 230 ? 122.079 115.622 140.505 1.00 21.50  ? 301 THR E N   1 
ATOM   5505 C CA  . THR C 1 230 ? 121.895 115.027 141.821 1.00 21.50  ? 301 THR E CA  1 
ATOM   5506 C C   . THR C 1 230 ? 122.402 116.008 142.872 1.00 21.50  ? 301 THR E C   1 
ATOM   5507 O O   . THR C 1 230 ? 122.855 117.112 142.554 1.00 21.50  ? 301 THR E O   1 
ATOM   5508 C CB  . THR C 1 230 ? 122.625 113.681 141.940 1.00 21.50  ? 301 THR E CB  1 
ATOM   5509 O OG1 . THR C 1 230 ? 124.011 113.856 141.617 1.00 21.50  ? 301 THR E OG1 1 
ATOM   5510 C CG2 . THR C 1 230 ? 122.014 112.648 141.004 1.00 21.50  ? 301 THR E CG2 1 
ATOM   5511 N N   . LYS C 1 231 ? 122.320 115.604 144.136 1.00 22.84  ? 302 LYS E N   1 
ATOM   5512 C CA  . LYS C 1 231 ? 122.856 116.427 145.210 1.00 22.84  ? 302 LYS E CA  1 
ATOM   5513 C C   . LYS C 1 231 ? 124.377 116.487 145.122 1.00 22.84  ? 302 LYS E C   1 
ATOM   5514 O O   . LYS C 1 231 ? 125.031 115.564 144.629 1.00 22.84  ? 302 LYS E O   1 
ATOM   5515 C CB  . LYS C 1 231 ? 122.427 115.883 146.573 1.00 22.84  ? 302 LYS E CB  1 
ATOM   5516 C CG  . LYS C 1 231 ? 122.966 114.500 146.896 1.00 22.84  ? 302 LYS E CG  1 
ATOM   5517 C CD  . LYS C 1 231 ? 122.580 114.078 148.305 1.00 22.84  ? 302 LYS E CD  1 
ATOM   5518 C CE  . LYS C 1 231 ? 123.165 112.720 148.656 1.00 22.84  ? 302 LYS E CE  1 
ATOM   5519 N NZ  . LYS C 1 231 ? 122.817 112.311 150.045 1.00 22.84  ? 302 LYS E NZ  1 
ATOM   5520 N N   . THR C 1 232 ? 124.937 117.591 145.596 1.00 22.74  ? 303 THR E N   1 
ATOM   5521 C CA  . THR C 1 232 ? 126.381 117.787 145.534 1.00 22.74  ? 303 THR E CA  1 
ATOM   5522 C C   . THR C 1 232 ? 127.082 116.798 146.457 1.00 22.74  ? 303 THR E C   1 
ATOM   5523 O O   . THR C 1 232 ? 126.781 116.767 147.658 1.00 22.74  ? 303 THR E O   1 
ATOM   5524 C CB  . THR C 1 232 ? 126.743 119.218 145.919 1.00 22.74  ? 303 THR E CB  1 
ATOM   5525 O OG1 . THR C 1 232 ? 126.073 120.135 145.044 1.00 22.74  ? 303 THR E OG1 1 
ATOM   5526 C CG2 . THR C 1 232 ? 128.246 119.433 145.813 1.00 22.74  ? 303 THR E CG2 1 
ATOM   5527 N N   . PRO C 1 233 ? 128.003 115.980 145.953 1.00 23.14  ? 304 PRO E N   1 
ATOM   5528 C CA  . PRO C 1 233 ? 128.687 115.018 146.822 1.00 23.14  ? 304 PRO E CA  1 
ATOM   5529 C C   . PRO C 1 233 ? 129.607 115.710 147.815 1.00 23.14  ? 304 PRO E C   1 
ATOM   5530 O O   . PRO C 1 233 ? 130.123 116.803 147.568 1.00 23.14  ? 304 PRO E O   1 
ATOM   5531 C CB  . PRO C 1 233 ? 129.482 114.153 145.837 1.00 23.14  ? 304 PRO E CB  1 
ATOM   5532 C CG  . PRO C 1 233 ? 129.698 115.042 144.657 1.00 23.14  ? 304 PRO E CG  1 
ATOM   5533 C CD  . PRO C 1 233 ? 128.465 115.895 144.557 1.00 23.14  ? 304 PRO E CD  1 
ATOM   5534 N N   . GLY C 1 234 ? 129.807 115.054 148.951 1.00 22.76  ? 305 GLY E N   1 
ATOM   5535 C CA  . GLY C 1 234 ? 130.666 115.560 150.002 1.00 22.76  ? 305 GLY E CA  1 
ATOM   5536 C C   . GLY C 1 234 ? 130.017 115.442 151.367 1.00 22.76  ? 305 GLY E C   1 
ATOM   5537 O O   . GLY C 1 234 ? 128.824 115.182 151.507 1.00 22.76  ? 305 GLY E O   1 
ATOM   5538 N N   . GLN C 1 235 ? 130.849 115.643 152.387 1.00 23.13  ? 306 GLN E N   1 
ATOM   5539 C CA  . GLN C 1 235 ? 130.401 115.573 153.774 1.00 23.13  ? 306 GLN E CA  1 
ATOM   5540 C C   . GLN C 1 235 ? 129.843 116.931 154.182 1.00 23.13  ? 306 GLN E C   1 
ATOM   5541 O O   . GLN C 1 235 ? 130.578 117.922 154.237 1.00 23.13  ? 306 GLN E O   1 
ATOM   5542 C CB  . GLN C 1 235 ? 131.551 115.153 154.685 1.00 23.13  ? 306 GLN E CB  1 
ATOM   5543 C CG  . GLN C 1 235 ? 131.162 114.990 156.146 1.00 23.13  ? 306 GLN E CG  1 
ATOM   5544 C CD  . GLN C 1 235 ? 130.242 113.806 156.381 1.00 23.13  ? 306 GLN E CD  1 
ATOM   5545 O OE1 . GLN C 1 235 ? 130.165 112.891 155.561 1.00 23.13  ? 306 GLN E OE1 1 
ATOM   5546 N NE2 . GLN C 1 235 ? 129.538 113.819 157.507 1.00 23.13  ? 306 GLN E NE2 1 
ATOM   5547 N N   . ARG C 1 236 ? 128.544 116.979 154.464 1.00 23.36  ? 307 ARG E N   1 
ATOM   5548 C CA  . ARG C 1 236 ? 127.909 118.227 154.863 1.00 23.36  ? 307 ARG E CA  1 
ATOM   5549 C C   . ARG C 1 236 ? 128.382 118.653 156.247 1.00 23.36  ? 307 ARG E C   1 
ATOM   5550 O O   . ARG C 1 236 ? 128.593 117.822 157.134 1.00 23.36  ? 307 ARG E O   1 
ATOM   5551 C CB  . ARG C 1 236 ? 126.388 118.075 154.847 1.00 23.36  ? 307 ARG E CB  1 
ATOM   5552 C CG  . ARG C 1 236 ? 125.806 117.801 153.470 1.00 23.36  ? 307 ARG E CG  1 
ATOM   5553 C CD  . ARG C 1 236 ? 124.288 117.721 153.515 1.00 23.36  ? 307 ARG E CD  1 
ATOM   5554 N NE  . ARG C 1 236 ? 123.820 116.596 154.315 1.00 23.36  ? 307 ARG E NE  1 
ATOM   5555 C CZ  . ARG C 1 236 ? 123.539 115.396 153.827 1.00 23.36  ? 307 ARG E CZ  1 
ATOM   5556 N NH1 . ARG C 1 236 ? 123.665 115.127 152.537 1.00 23.36  ? 307 ARG E NH1 1 
ATOM   5557 N NH2 . ARG C 1 236 ? 123.118 114.441 154.652 1.00 23.36  ? 307 ARG E NH2 1 
ATOM   5558 N N   . SER C 1 237 ? 128.549 119.962 156.428 1.00 18.94  ? 308 SER E N   1 
ATOM   5559 C CA  . SER C 1 237 ? 129.014 120.529 157.684 1.00 18.94  ? 308 SER E CA  1 
ATOM   5560 C C   . SER C 1 237 ? 128.130 121.702 158.079 1.00 18.94  ? 308 SER E C   1 
ATOM   5561 O O   . SER C 1 237 ? 127.573 122.397 157.224 1.00 18.94  ? 308 SER E O   1 
ATOM   5562 C CB  . SER C 1 237 ? 130.476 120.987 157.587 1.00 18.94  ? 308 SER E CB  1 
ATOM   5563 O OG  . SER C 1 237 ? 130.919 121.544 158.812 1.00 18.94  ? 308 SER E OG  1 
ATOM   5564 N N   . ALA C 1 238 ? 128.006 121.915 159.384 1.00 18.42  ? 309 ALA E N   1 
ATOM   5565 C CA  . ALA C 1 238 ? 127.181 123.001 159.898 1.00 18.42  ? 309 ALA E CA  1 
ATOM   5566 C C   . ALA C 1 238 ? 127.929 124.324 159.778 1.00 18.42  ? 309 ALA E C   1 
ATOM   5567 O O   . ALA C 1 238 ? 129.030 124.452 160.325 1.00 18.42  ? 309 ALA E O   1 
ATOM   5568 C CB  . ALA C 1 238 ? 126.800 122.743 161.349 1.00 18.42  ? 309 ALA E CB  1 
ATOM   5569 N N   . PRO C 1 239 ? 127.382 125.317 159.080 1.00 17.30  ? 310 PRO E N   1 
ATOM   5570 C CA  . PRO C 1 239 ? 128.072 126.605 158.966 1.00 17.30  ? 310 PRO E CA  1 
ATOM   5571 C C   . PRO C 1 239 ? 128.137 127.342 160.294 1.00 17.30  ? 310 PRO E C   1 
ATOM   5572 O O   . PRO C 1 239 ? 127.277 127.188 161.165 1.00 17.30  ? 310 PRO E O   1 
ATOM   5573 C CB  . PRO C 1 239 ? 127.221 127.375 157.949 1.00 17.30  ? 310 PRO E CB  1 
ATOM   5574 C CG  . PRO C 1 239 ? 125.875 126.739 158.022 1.00 17.30  ? 310 PRO E CG  1 
ATOM   5575 C CD  . PRO C 1 239 ? 126.126 125.289 158.313 1.00 17.30  ? 310 PRO E CD  1 
ATOM   5576 N N   . GLU C 1 240 ? 129.181 128.154 160.438 1.00 19.71  ? 311 GLU E N   1 
ATOM   5577 C CA  . GLU C 1 240 ? 129.367 129.023 161.594 1.00 19.71  ? 311 GLU E CA  1 
ATOM   5578 C C   . GLU C 1 240 ? 129.108 130.458 161.158 1.00 19.71  ? 311 GLU E C   1 
ATOM   5579 O O   . GLU C 1 240 ? 129.751 130.950 160.224 1.00 19.71  ? 311 GLU E O   1 
ATOM   5580 C CB  . GLU C 1 240 ? 130.775 128.874 162.169 1.00 19.71  ? 311 GLU E CB  1 
ATOM   5581 C CG  . GLU C 1 240 ? 131.143 127.449 162.548 1.00 19.71  ? 311 GLU E CG  1 
ATOM   5582 C CD  . GLU C 1 240 ? 132.579 127.322 163.016 1.00 19.71  ? 311 GLU E CD  1 
ATOM   5583 O OE1 . GLU C 1 240 ? 133.287 128.350 163.053 1.00 19.71  ? 311 GLU E OE1 1 
ATOM   5584 O OE2 . GLU C 1 240 ? 133.001 126.193 163.346 1.00 19.71  ? 311 GLU E OE2 1 
ATOM   5585 N N   . VAL C 1 241 ? 128.176 131.126 161.833 1.00 19.19  ? 312 VAL E N   1 
ATOM   5586 C CA  . VAL C 1 241 ? 127.701 132.448 161.439 1.00 19.19  ? 312 VAL E CA  1 
ATOM   5587 C C   . VAL C 1 241 ? 128.001 133.430 162.562 1.00 19.19  ? 312 VAL E C   1 
ATOM   5588 O O   . VAL C 1 241 ? 127.698 133.157 163.730 1.00 19.19  ? 312 VAL E O   1 
ATOM   5589 C CB  . VAL C 1 241 ? 126.197 132.431 161.116 1.00 19.19  ? 312 VAL E CB  1 
ATOM   5590 C CG1 . VAL C 1 241 ? 125.745 133.793 160.616 1.00 19.19  ? 312 VAL E CG1 1 
ATOM   5591 C CG2 . VAL C 1 241 ? 125.890 131.348 160.095 1.00 19.19  ? 312 VAL E CG2 1 
ATOM   5592 N N   . TYR C 1 242 ? 128.595 134.570 162.209 1.00 19.12  ? 313 TYR E N   1 
ATOM   5593 C CA  . TYR C 1 242 ? 128.936 135.597 163.183 1.00 19.12  ? 313 TYR E CA  1 
ATOM   5594 C C   . TYR C 1 242 ? 128.617 136.973 162.618 1.00 19.12  ? 313 TYR E C   1 
ATOM   5595 O O   . TYR C 1 242 ? 128.923 137.263 161.459 1.00 19.12  ? 313 TYR E O   1 
ATOM   5596 C CB  . TYR C 1 242 ? 130.417 135.522 163.575 1.00 19.12  ? 313 TYR E CB  1 
ATOM   5597 C CG  . TYR C 1 242 ? 130.842 134.165 164.090 1.00 19.12  ? 313 TYR E CG  1 
ATOM   5598 C CD1 . TYR C 1 242 ? 130.689 133.830 165.429 1.00 19.12  ? 313 TYR E CD1 1 
ATOM   5599 C CD2 . TYR C 1 242 ? 131.394 133.219 163.237 1.00 19.12  ? 313 TYR E CD2 1 
ATOM   5600 C CE1 . TYR C 1 242 ? 131.075 132.590 165.904 1.00 19.12  ? 313 TYR E CE1 1 
ATOM   5601 C CE2 . TYR C 1 242 ? 131.782 131.977 163.702 1.00 19.12  ? 313 TYR E CE2 1 
ATOM   5602 C CZ  . TYR C 1 242 ? 131.621 131.668 165.035 1.00 19.12  ? 313 TYR E CZ  1 
ATOM   5603 O OH  . TYR C 1 242 ? 132.006 130.433 165.503 1.00 19.12  ? 313 TYR E OH  1 
ATOM   5604 N N   . VAL C 1 243 ? 128.018 137.824 163.446 1.00 18.61  ? 314 VAL E N   1 
ATOM   5605 C CA  . VAL C 1 243 ? 127.640 139.179 163.057 1.00 18.61  ? 314 VAL E CA  1 
ATOM   5606 C C   . VAL C 1 243 ? 128.556 140.160 163.775 1.00 18.61  ? 314 VAL E C   1 
ATOM   5607 O O   . VAL C 1 243 ? 128.720 140.085 164.999 1.00 18.61  ? 314 VAL E O   1 
ATOM   5608 C CB  . VAL C 1 243 ? 126.164 139.469 163.376 1.00 18.61  ? 314 VAL E CB  1 
ATOM   5609 C CG1 . VAL C 1 243 ? 125.831 140.921 163.072 1.00 18.61  ? 314 VAL E CG1 1 
ATOM   5610 C CG2 . VAL C 1 243 ? 125.263 138.540 162.582 1.00 18.61  ? 314 VAL E CG2 1 
ATOM   5611 N N   . PHE C 1 244 ? 129.151 141.077 163.014 1.00 19.79  ? 315 PHE E N   1 
ATOM   5612 C CA  . PHE C 1 244 ? 130.070 142.034 163.615 1.00 19.79  ? 315 PHE E CA  1 
ATOM   5613 C C   . PHE C 1 244 ? 129.392 143.383 163.823 1.00 19.79  ? 315 PHE E C   1 
ATOM   5614 O O   . PHE C 1 244 ? 128.585 143.809 162.989 1.00 19.79  ? 315 PHE E O   1 
ATOM   5615 C CB  . PHE C 1 244 ? 131.307 142.222 162.736 1.00 19.79  ? 315 PHE E CB  1 
ATOM   5616 C CG  . PHE C 1 244 ? 132.064 140.951 162.476 1.00 19.79  ? 315 PHE E CG  1 
ATOM   5617 C CD1 . PHE C 1 244 ? 133.018 140.501 163.373 1.00 19.79  ? 315 PHE E CD1 1 
ATOM   5618 C CD2 . PHE C 1 244 ? 131.824 140.208 161.332 1.00 19.79  ? 315 PHE E CD2 1 
ATOM   5619 C CE1 . PHE C 1 244 ? 133.717 139.332 163.136 1.00 19.79  ? 315 PHE E CE1 1 
ATOM   5620 C CE2 . PHE C 1 244 ? 132.520 139.039 161.088 1.00 19.79  ? 315 PHE E CE2 1 
ATOM   5621 C CZ  . PHE C 1 244 ? 133.467 138.600 161.992 1.00 19.79  ? 315 PHE E CZ  1 
ATOM   5622 N N   . PRO C 1 245 ? 129.700 144.068 164.921 1.00 24.69  ? 316 PRO E N   1 
ATOM   5623 C CA  . PRO C 1 245 ? 129.135 145.402 165.154 1.00 24.69  ? 316 PRO E CA  1 
ATOM   5624 C C   . PRO C 1 245 ? 129.705 146.411 164.176 1.00 24.69  ? 316 PRO E C   1 
ATOM   5625 O O   . PRO C 1 245 ? 130.810 146.216 163.646 1.00 24.69  ? 316 PRO E O   1 
ATOM   5626 C CB  . PRO C 1 245 ? 129.560 145.717 166.596 1.00 24.69  ? 316 PRO E CB  1 
ATOM   5627 C CG  . PRO C 1 245 ? 130.790 144.902 166.806 1.00 24.69  ? 316 PRO E CG  1 
ATOM   5628 C CD  . PRO C 1 245 ? 130.577 143.637 166.023 1.00 24.69  ? 316 PRO E CD  1 
ATOM   5629 N N   . PRO C 1 246 ? 128.980 147.492 163.897 1.00 25.82  ? 317 PRO E N   1 
ATOM   5630 C CA  . PRO C 1 246 ? 129.483 148.512 162.967 1.00 25.82  ? 317 PRO E CA  1 
ATOM   5631 C C   . PRO C 1 246 ? 130.778 149.121 163.470 1.00 25.82  ? 317 PRO E C   1 
ATOM   5632 O O   . PRO C 1 246 ? 130.928 149.385 164.672 1.00 25.82  ? 317 PRO E O   1 
ATOM   5633 C CB  . PRO C 1 246 ? 128.354 149.553 162.937 1.00 25.82  ? 317 PRO E CB  1 
ATOM   5634 C CG  . PRO C 1 246 ? 127.140 148.809 163.367 1.00 25.82  ? 317 PRO E CG  1 
ATOM   5635 C CD  . PRO C 1 246 ? 127.618 147.797 164.365 1.00 25.82  ? 317 PRO E CD  1 
ATOM   5636 N N   . PRO C 1 247 ? 131.739 149.360 162.579 1.00 29.66  ? 318 PRO E N   1 
ATOM   5637 C CA  . PRO C 1 247 ? 133.020 149.952 162.981 1.00 29.66  ? 318 PRO E CA  1 
ATOM   5638 C C   . PRO C 1 247 ? 133.104 151.464 162.838 1.00 29.66  ? 318 PRO E C   1 
ATOM   5639 O O   . PRO C 1 247 ? 134.120 152.044 163.239 1.00 29.66  ? 318 PRO E O   1 
ATOM   5640 C CB  . PRO C 1 247 ? 133.997 149.270 162.018 1.00 29.66  ? 318 PRO E CB  1 
ATOM   5641 C CG  . PRO C 1 247 ? 133.197 149.126 160.760 1.00 29.66  ? 318 PRO E CG  1 
ATOM   5642 C CD  . PRO C 1 247 ? 131.763 148.894 161.181 1.00 29.66  ? 318 PRO E CD  1 
ATOM   5643 N N   . GLU C 1 248 ? 132.084 152.111 162.282 1.00 38.24  ? 319 GLU E N   1 
ATOM   5644 C CA  . GLU C 1 248 ? 132.146 153.546 162.040 1.00 38.24  ? 319 GLU E CA  1 
ATOM   5645 C C   . GLU C 1 248 ? 132.103 154.309 163.359 1.00 38.24  ? 319 GLU E C   1 
ATOM   5646 O O   . GLU C 1 248 ? 131.230 154.072 164.200 1.00 38.24  ? 319 GLU E O   1 
ATOM   5647 C CB  . GLU C 1 248 ? 131.003 153.965 161.121 1.00 38.24  ? 319 GLU E CB  1 
ATOM   5648 C CG  . GLU C 1 248 ? 131.035 153.229 159.790 1.00 38.24  ? 319 GLU E CG  1 
ATOM   5649 C CD  . GLU C 1 248 ? 129.918 153.637 158.859 1.00 38.24  ? 319 GLU E CD  1 
ATOM   5650 O OE1 . GLU C 1 248 ? 128.849 154.050 159.353 1.00 38.24  ? 319 GLU E OE1 1 
ATOM   5651 O OE2 . GLU C 1 248 ? 130.114 153.546 157.629 1.00 38.24  ? 319 GLU E OE2 1 
ATOM   5652 N N   . GLU C 1 249 ? 133.054 155.228 163.534 1.00 53.21  ? 320 GLU E N   1 
ATOM   5653 C CA  . GLU C 1 249 ? 133.345 155.807 164.840 1.00 53.21  ? 320 GLU E CA  1 
ATOM   5654 C C   . GLU C 1 249 ? 132.196 156.611 165.441 1.00 53.21  ? 320 GLU E C   1 
ATOM   5655 O O   . GLU C 1 249 ? 131.636 156.214 166.468 1.00 53.21  ? 320 GLU E O   1 
ATOM   5656 C CB  . GLU C 1 249 ? 134.595 156.688 164.749 1.00 53.21  ? 320 GLU E CB  1 
ATOM   5657 C CG  . GLU C 1 249 ? 135.880 155.929 164.434 1.00 53.21  ? 320 GLU E CG  1 
ATOM   5658 C CD  . GLU C 1 249 ? 136.033 155.611 162.958 1.00 53.21  ? 320 GLU E CD  1 
ATOM   5659 O OE1 . GLU C 1 249 ? 135.209 156.097 162.155 1.00 53.21  ? 320 GLU E OE1 1 
ATOM   5660 O OE2 . GLU C 1 249 ? 136.978 154.876 162.601 1.00 53.21  ? 320 GLU E OE2 1 
ATOM   5661 N N   . GLU C 1 250 ? 131.831 157.736 164.825 1.00 60.60  ? 321 GLU E N   1 
ATOM   5662 C CA  . GLU C 1 250 ? 130.905 158.661 165.470 1.00 60.60  ? 321 GLU E CA  1 
ATOM   5663 C C   . GLU C 1 250 ? 129.635 158.931 164.678 1.00 60.60  ? 321 GLU E C   1 
ATOM   5664 O O   . GLU C 1 250 ? 128.541 158.585 165.141 1.00 60.60  ? 321 GLU E O   1 
ATOM   5665 C CB  . GLU C 1 250 ? 131.626 159.988 165.766 1.00 60.60  ? 321 GLU E CB  1 
ATOM   5666 C CG  . GLU C 1 250 ? 132.569 160.447 164.662 1.00 60.60  ? 321 GLU E CG  1 
ATOM   5667 C CD  . GLU C 1 250 ? 133.226 161.778 164.972 1.00 60.60  ? 321 GLU E CD  1 
ATOM   5668 O OE1 . GLU C 1 250 ? 133.014 162.302 166.085 1.00 60.60  ? 321 GLU E OE1 1 
ATOM   5669 O OE2 . GLU C 1 250 ? 133.954 162.300 164.101 1.00 60.60  ? 321 GLU E OE2 1 
ATOM   5670 N N   . SER C 1 251 ? 129.739 159.528 163.491 1.00 57.84  ? 322 SER E N   1 
ATOM   5671 C CA  . SER C 1 251 ? 128.563 160.107 162.848 1.00 57.84  ? 322 SER E CA  1 
ATOM   5672 C C   . SER C 1 251 ? 128.554 159.799 161.357 1.00 57.84  ? 322 SER E C   1 
ATOM   5673 O O   . SER C 1 251 ? 128.063 160.594 160.548 1.00 57.84  ? 322 SER E O   1 
ATOM   5674 C CB  . SER C 1 251 ? 128.490 161.619 163.085 1.00 57.84  ? 322 SER E CB  1 
ATOM   5675 O OG  . SER C 1 251 ? 127.342 162.180 162.471 1.00 57.84  ? 322 SER E OG  1 
ATOM   5676 N N   . GLU C 1 252 ? 129.099 158.648 160.974 1.00 54.09  ? 323 GLU E N   1 
ATOM   5677 C CA  . GLU C 1 252 ? 129.061 158.250 159.574 1.00 54.09  ? 323 GLU E CA  1 
ATOM   5678 C C   . GLU C 1 252 ? 127.627 157.930 159.172 1.00 54.09  ? 323 GLU E C   1 
ATOM   5679 O O   . GLU C 1 252 ? 126.924 157.191 159.869 1.00 54.09  ? 323 GLU E O   1 
ATOM   5680 C CB  . GLU C 1 252 ? 129.975 157.051 159.331 1.00 54.09  ? 323 GLU E CB  1 
ATOM   5681 C CG  . GLU C 1 252 ? 131.447 157.340 159.581 1.00 54.09  ? 323 GLU E CG  1 
ATOM   5682 C CD  . GLU C 1 252 ? 132.360 156.357 158.876 1.00 54.09  ? 323 GLU E CD  1 
ATOM   5683 O OE1 . GLU C 1 252 ? 131.931 155.769 157.862 1.00 54.09  ? 323 GLU E OE1 1 
ATOM   5684 O OE2 . GLU C 1 252 ? 133.506 156.172 159.337 1.00 54.09  ? 323 GLU E OE2 1 
ATOM   5685 N N   . ASP C 1 253 ? 127.194 158.493 158.042 1.00 50.75  ? 324 ASP E N   1 
ATOM   5686 C CA  . ASP C 1 253 ? 125.778 158.478 157.695 1.00 50.75  ? 324 ASP E CA  1 
ATOM   5687 C C   . ASP C 1 253 ? 125.297 157.092 157.280 1.00 50.75  ? 324 ASP E C   1 
ATOM   5688 O O   . ASP C 1 253 ? 124.127 156.757 157.496 1.00 50.75  ? 324 ASP E O   1 
ATOM   5689 C CB  . ASP C 1 253 ? 125.505 159.487 156.579 1.00 50.75  ? 324 ASP E CB  1 
ATOM   5690 C CG  . ASP C 1 253 ? 124.032 159.817 156.435 1.00 50.75  ? 324 ASP E CG  1 
ATOM   5691 O OD1 . ASP C 1 253 ? 123.242 159.432 157.323 1.00 50.75  ? 324 ASP E OD1 1 
ATOM   5692 O OD2 . ASP C 1 253 ? 123.663 160.465 155.433 1.00 50.75  ? 324 ASP E OD2 1 
ATOM   5693 N N   . LYS C 1 254 ? 126.165 156.279 156.689 1.00 43.98  ? 325 LYS E N   1 
ATOM   5694 C CA  . LYS C 1 254 ? 125.778 154.980 156.145 1.00 43.98  ? 325 LYS E CA  1 
ATOM   5695 C C   . LYS C 1 254 ? 126.381 153.885 157.023 1.00 43.98  ? 325 LYS E C   1 
ATOM   5696 O O   . LYS C 1 254 ? 127.509 153.441 156.803 1.00 43.98  ? 325 LYS E O   1 
ATOM   5697 C CB  . LYS C 1 254 ? 126.224 154.849 154.690 1.00 43.98  ? 325 LYS E CB  1 
ATOM   5698 C CG  . LYS C 1 254 ? 125.697 155.955 153.787 1.00 43.98  ? 325 LYS E CG  1 
ATOM   5699 C CD  . LYS C 1 254 ? 126.142 155.763 152.347 1.00 43.98  ? 325 LYS E CD  1 
ATOM   5700 C CE  . LYS C 1 254 ? 125.554 154.495 151.751 1.00 43.98  ? 325 LYS E CE  1 
ATOM   5701 N NZ  . LYS C 1 254 ? 124.065 154.515 151.749 1.00 43.98  ? 325 LYS E NZ  1 
ATOM   5702 N N   . ARG C 1 255 ? 125.612 153.445 158.016 1.00 36.72  ? 326 ARG E N   1 
ATOM   5703 C CA  . ARG C 1 255 ? 126.057 152.376 158.896 1.00 36.72  ? 326 ARG E CA  1 
ATOM   5704 C C   . ARG C 1 255 ? 126.125 151.054 158.140 1.00 36.72  ? 326 ARG E C   1 
ATOM   5705 O O   . ARG C 1 255 ? 125.311 150.770 157.255 1.00 36.72  ? 326 ARG E O   1 
ATOM   5706 C CB  . ARG C 1 255 ? 125.122 152.247 160.099 1.00 36.72  ? 326 ARG E CB  1 
ATOM   5707 C CG  . ARG C 1 255 ? 125.179 153.423 161.060 1.00 36.72  ? 326 ARG E CG  1 
ATOM   5708 C CD  . ARG C 1 255 ? 126.576 153.595 161.633 1.00 36.72  ? 326 ARG E CD  1 
ATOM   5709 N NE  . ARG C 1 255 ? 126.649 154.696 162.586 1.00 36.72  ? 326 ARG E NE  1 
ATOM   5710 C CZ  . ARG C 1 255 ? 126.497 154.564 163.897 1.00 36.72  ? 326 ARG E CZ  1 
ATOM   5711 N NH1 . ARG C 1 255 ? 126.261 153.385 164.450 1.00 36.72  ? 326 ARG E NH1 1 
ATOM   5712 N NH2 . ARG C 1 255 ? 126.584 155.641 164.672 1.00 36.72  ? 326 ARG E NH2 1 
ATOM   5713 N N   . THR C 1 256 ? 127.111 150.238 158.507 1.00 30.07  ? 327 THR E N   1 
ATOM   5714 C CA  . THR C 1 256 ? 127.413 148.990 157.819 1.00 30.07  ? 327 THR E CA  1 
ATOM   5715 C C   . THR C 1 256 ? 127.382 147.837 158.811 1.00 30.07  ? 327 THR E C   1 
ATOM   5716 O O   . THR C 1 256 ? 127.960 147.932 159.899 1.00 30.07  ? 327 THR E O   1 
ATOM   5717 C CB  . THR C 1 256 ? 128.783 149.065 157.135 1.00 30.07  ? 327 THR E CB  1 
ATOM   5718 O OG1 . THR C 1 256 ? 128.756 150.072 156.115 1.00 30.07  ? 327 THR E OG1 1 
ATOM   5719 C CG2 . THR C 1 256 ? 129.151 147.729 156.513 1.00 30.07  ? 327 THR E CG2 1 
ATOM   5720 N N   . LEU C 1 257 ? 126.707 146.753 158.434 1.00 23.39  ? 328 LEU E N   1 
ATOM   5721 C CA  . LEU C 1 257 ? 126.656 145.527 159.215 1.00 23.39  ? 328 LEU E CA  1 
ATOM   5722 C C   . LEU C 1 257 ? 127.224 144.382 158.389 1.00 23.39  ? 328 LEU E C   1 
ATOM   5723 O O   . LEU C 1 257 ? 126.920 144.251 157.198 1.00 23.39  ? 328 LEU E O   1 
ATOM   5724 C CB  . LEU C 1 257 ? 125.223 145.200 159.648 1.00 23.39  ? 328 LEU E CB  1 
ATOM   5725 C CG  . LEU C 1 257 ? 124.609 146.085 160.733 1.00 23.39  ? 328 LEU E CG  1 
ATOM   5726 C CD1 . LEU C 1 257 ? 123.140 145.750 160.928 1.00 23.39  ? 328 LEU E CD1 1 
ATOM   5727 C CD2 . LEU C 1 257 ? 125.371 145.924 162.037 1.00 23.39  ? 328 LEU E CD2 1 
ATOM   5728 N N   . THR C 1 258 ? 128.049 143.555 159.028 1.00 20.23  ? 329 THR E N   1 
ATOM   5729 C CA  . THR C 1 258 ? 128.722 142.443 158.372 1.00 20.23  ? 329 THR E CA  1 
ATOM   5730 C C   . THR C 1 258 ? 128.280 141.135 159.012 1.00 20.23  ? 329 THR E C   1 
ATOM   5731 O O   . THR C 1 258 ? 128.259 141.016 160.243 1.00 20.23  ? 329 THR E O   1 
ATOM   5732 C CB  . THR C 1 258 ? 130.245 142.589 158.466 1.00 20.23  ? 329 THR E CB  1 
ATOM   5733 O OG1 . THR C 1 258 ? 130.650 143.809 157.834 1.00 20.23  ? 329 THR E OG1 1 
ATOM   5734 C CG2 . THR C 1 258 ? 130.939 141.417 157.786 1.00 20.23  ? 329 THR E CG2 1 
ATOM   5735 N N   . CYS C 1 259 ? 127.922 140.161 158.176 1.00 19.68  ? 330 CYS E N   1 
ATOM   5736 C CA  . CYS C 1 259 ? 127.544 138.825 158.628 1.00 19.68  ? 330 CYS E CA  1 
ATOM   5737 C C   . CYS C 1 259 ? 128.416 137.824 157.880 1.00 19.68  ? 330 CYS E C   1 
ATOM   5738 O O   . CYS C 1 259 ? 128.306 137.692 156.657 1.00 19.68  ? 330 CYS E O   1 
ATOM   5739 C CB  . CYS C 1 259 ? 126.054 138.564 158.391 1.00 19.68  ? 330 CYS E CB  1 
ATOM   5740 S SG  . CYS C 1 259 ? 125.391 137.060 159.150 1.00 19.68  ? 330 CYS E SG  1 
ATOM   5741 N N   . LEU C 1 260 ? 129.292 137.137 158.608 1.00 16.62  ? 331 LEU E N   1 
ATOM   5742 C CA  . LEU C 1 260 ? 130.264 136.218 158.033 1.00 16.62  ? 331 LEU E CA  1 
ATOM   5743 C C   . LEU C 1 260 ? 129.833 134.784 158.298 1.00 16.62  ? 331 LEU E C   1 
ATOM   5744 O O   . LEU C 1 260 ? 129.489 134.432 159.433 1.00 16.62  ? 331 LEU E O   1 
ATOM   5745 C CB  . LEU C 1 260 ? 131.659 136.467 158.616 1.00 16.62  ? 331 LEU E CB  1 
ATOM   5746 C CG  . LEU C 1 260 ? 132.671 135.317 158.574 1.00 16.62  ? 331 LEU E CG  1 
ATOM   5747 C CD1 . LEU C 1 260 ? 133.032 134.932 157.145 1.00 16.62  ? 331 LEU E CD1 1 
ATOM   5748 C CD2 . LEU C 1 260 ? 133.920 135.678 159.365 1.00 16.62  ? 331 LEU E CD2 1 
ATOM   5749 N N   . ILE C 1 261 ? 129.857 133.961 157.252 1.00 16.32  ? 332 ILE E N   1 
ATOM   5750 C CA  . ILE C 1 261 ? 129.536 132.543 157.347 1.00 16.32  ? 332 ILE E CA  1 
ATOM   5751 C C   . ILE C 1 261 ? 130.755 131.756 156.892 1.00 16.32  ? 332 ILE E C   1 
ATOM   5752 O O   . ILE C 1 261 ? 131.294 132.010 155.810 1.00 16.32  ? 332 ILE E O   1 
ATOM   5753 C CB  . ILE C 1 261 ? 128.301 132.175 156.504 1.00 16.32  ? 332 ILE E CB  1 
ATOM   5754 C CG1 . ILE C 1 261 ? 127.072 132.962 156.970 1.00 16.32  ? 332 ILE E CG1 1 
ATOM   5755 C CG2 . ILE C 1 261 ? 128.034 130.683 156.580 1.00 16.32  ? 332 ILE E CG2 1 
ATOM   5756 C CD1 . ILE C 1 261 ? 126.868 134.287 156.258 1.00 16.32  ? 332 ILE E CD1 1 
ATOM   5757 N N   . GLN C 1 262 ? 131.188 130.806 157.716 1.00 21.08  ? 333 GLN E N   1 
ATOM   5758 C CA  . GLN C 1 262 ? 132.399 130.046 157.448 1.00 21.08  ? 333 GLN E CA  1 
ATOM   5759 C C   . GLN C 1 262 ? 132.144 128.560 157.652 1.00 21.08  ? 333 GLN E C   1 
ATOM   5760 O O   . GLN C 1 262 ? 131.278 128.162 158.436 1.00 21.08  ? 333 GLN E O   1 
ATOM   5761 C CB  . GLN C 1 262 ? 133.554 130.504 158.348 1.00 21.08  ? 333 GLN E CB  1 
ATOM   5762 C CG  . GLN C 1 262 ? 133.284 130.339 159.834 1.00 21.08  ? 333 GLN E CG  1 
ATOM   5763 C CD  . GLN C 1 262 ? 134.394 130.908 160.693 1.00 21.08  ? 333 GLN E CD  1 
ATOM   5764 O OE1 . GLN C 1 262 ? 135.241 131.660 160.213 1.00 21.08  ? 333 GLN E OE1 1 
ATOM   5765 N NE2 . GLN C 1 262 ? 134.396 130.549 161.971 1.00 21.08  ? 333 GLN E NE2 1 
ATOM   5766 N N   . ASN C 1 263 ? 132.916 127.747 156.929 1.00 22.64  ? 334 ASN E N   1 
ATOM   5767 C CA  . ASN C 1 263 ? 132.883 126.289 157.040 1.00 22.64  ? 334 ASN E CA  1 
ATOM   5768 C C   . ASN C 1 263 ? 131.481 125.740 156.767 1.00 22.64  ? 334 ASN E C   1 
ATOM   5769 O O   . ASN C 1 263 ? 130.853 125.103 157.615 1.00 22.64  ? 334 ASN E O   1 
ATOM   5770 C CB  . ASN C 1 263 ? 133.398 125.835 158.410 1.00 22.64  ? 334 ASN E CB  1 
ATOM   5771 C CG  . ASN C 1 263 ? 134.830 126.262 158.665 1.00 22.64  ? 334 ASN E CG  1 
ATOM   5772 O OD1 . ASN C 1 263 ? 135.115 126.986 159.619 1.00 22.64  ? 334 ASN E OD1 1 
ATOM   5773 N ND2 . ASN C 1 263 ? 135.742 125.814 157.809 1.00 22.64  ? 334 ASN E ND2 1 
ATOM   5774 N N   . PHE C 1 264 ? 130.995 126.002 155.555 1.00 18.24  ? 335 PHE E N   1 
ATOM   5775 C CA  . PHE C 1 264 ? 129.731 125.455 155.083 1.00 18.24  ? 335 PHE E CA  1 
ATOM   5776 C C   . PHE C 1 264 ? 129.978 124.649 153.817 1.00 18.24  ? 335 PHE E C   1 
ATOM   5777 O O   . PHE C 1 264 ? 130.698 125.098 152.918 1.00 18.24  ? 335 PHE E O   1 
ATOM   5778 C CB  . PHE C 1 264 ? 128.694 126.558 154.831 1.00 18.24  ? 335 PHE E CB  1 
ATOM   5779 C CG  . PHE C 1 264 ? 129.104 127.569 153.796 1.00 18.24  ? 335 PHE E CG  1 
ATOM   5780 C CD1 . PHE C 1 264 ? 129.848 128.681 154.152 1.00 18.24  ? 335 PHE E CD1 1 
ATOM   5781 C CD2 . PHE C 1 264 ? 128.721 127.422 152.473 1.00 18.24  ? 335 PHE E CD2 1 
ATOM   5782 C CE1 . PHE C 1 264 ? 130.217 129.618 153.206 1.00 18.24  ? 335 PHE E CE1 1 
ATOM   5783 C CE2 . PHE C 1 264 ? 129.090 128.353 151.522 1.00 18.24  ? 335 PHE E CE2 1 
ATOM   5784 C CZ  . PHE C 1 264 ? 129.837 129.453 151.889 1.00 18.24  ? 335 PHE E CZ  1 
ATOM   5785 N N   . PHE C 1 265 ? 129.393 123.452 153.758 1.00 19.72  ? 336 PHE E N   1 
ATOM   5786 C CA  . PHE C 1 265 ? 129.523 122.568 152.616 1.00 19.72  ? 336 PHE E CA  1 
ATOM   5787 C C   . PHE C 1 265 ? 128.226 121.784 152.498 1.00 19.72  ? 336 PHE E C   1 
ATOM   5788 O O   . PHE C 1 265 ? 127.707 121.311 153.519 1.00 19.72  ? 336 PHE E O   1 
ATOM   5789 C CB  . PHE C 1 265 ? 130.711 121.612 152.763 1.00 19.72  ? 336 PHE E CB  1 
ATOM   5790 C CG  . PHE C 1 265 ? 131.120 120.947 151.480 1.00 19.72  ? 336 PHE E CG  1 
ATOM   5791 C CD1 . PHE C 1 265 ? 132.009 121.567 150.618 1.00 19.72  ? 336 PHE E CD1 1 
ATOM   5792 C CD2 . PHE C 1 265 ? 130.619 119.702 151.137 1.00 19.72  ? 336 PHE E CD2 1 
ATOM   5793 C CE1 . PHE C 1 265 ? 132.389 120.959 149.436 1.00 19.72  ? 336 PHE E CE1 1 
ATOM   5794 C CE2 . PHE C 1 265 ? 130.995 119.090 149.957 1.00 19.72  ? 336 PHE E CE2 1 
ATOM   5795 C CZ  . PHE C 1 265 ? 131.881 119.719 149.105 1.00 19.72  ? 336 PHE E CZ  1 
ATOM   5796 N N   . PRO C 1 266 ? 127.680 121.623 151.286 1.00 19.86  ? 337 PRO E N   1 
ATOM   5797 C CA  . PRO C 1 266 ? 128.192 122.089 149.989 1.00 19.86  ? 337 PRO E CA  1 
ATOM   5798 C C   . PRO C 1 266 ? 127.897 123.560 149.708 1.00 19.86  ? 337 PRO E C   1 
ATOM   5799 O O   . PRO C 1 266 ? 127.641 124.346 150.616 1.00 19.86  ? 337 PRO E O   1 
ATOM   5800 C CB  . PRO C 1 266 ? 127.467 121.171 148.998 1.00 19.86  ? 337 PRO E CB  1 
ATOM   5801 C CG  . PRO C 1 266 ? 126.138 120.933 149.649 1.00 19.86  ? 337 PRO E CG  1 
ATOM   5802 C CD  . PRO C 1 266 ? 126.434 120.850 151.129 1.00 19.86  ? 337 PRO E CD  1 
ATOM   5803 N N   . GLU C 1 267 ? 127.937 123.943 148.430 1.00 20.81  ? 338 GLU E N   1 
ATOM   5804 C CA  . GLU C 1 267 ? 127.749 125.336 148.041 1.00 20.81  ? 338 GLU E CA  1 
ATOM   5805 C C   . GLU C 1 267 ? 126.350 125.851 148.358 1.00 20.81  ? 338 GLU E C   1 
ATOM   5806 O O   . GLU C 1 267 ? 126.150 127.069 148.421 1.00 20.81  ? 338 GLU E O   1 
ATOM   5807 C CB  . GLU C 1 267 ? 128.035 125.492 146.544 1.00 20.81  ? 338 GLU E CB  1 
ATOM   5808 C CG  . GLU C 1 267 ? 128.265 126.921 146.076 1.00 20.81  ? 338 GLU E CG  1 
ATOM   5809 C CD  . GLU C 1 267 ? 129.692 127.388 146.293 1.00 20.81  ? 338 GLU E CD  1 
ATOM   5810 O OE1 . GLU C 1 267 ? 130.470 126.660 146.946 1.00 20.81  ? 338 GLU E OE1 1 
ATOM   5811 O OE2 . GLU C 1 267 ? 130.038 128.483 145.802 1.00 20.81  ? 338 GLU E OE2 1 
ATOM   5812 N N   . ASP C 1 268 ? 125.383 124.960 148.566 1.00 21.04  ? 339 ASP E N   1 
ATOM   5813 C CA  . ASP C 1 268 ? 123.996 125.366 148.771 1.00 21.04  ? 339 ASP E CA  1 
ATOM   5814 C C   . ASP C 1 268 ? 123.843 126.035 150.132 1.00 21.04  ? 339 ASP E C   1 
ATOM   5815 O O   . ASP C 1 268 ? 123.958 125.378 151.172 1.00 21.04  ? 339 ASP E O   1 
ATOM   5816 C CB  . ASP C 1 268 ? 123.073 124.156 148.652 1.00 21.04  ? 339 ASP E CB  1 
ATOM   5817 C CG  . ASP C 1 268 ? 123.164 123.486 147.295 1.00 21.04  ? 339 ASP E CG  1 
ATOM   5818 O OD1 . ASP C 1 268 ? 123.451 124.187 146.302 1.00 21.04  ? 339 ASP E OD1 1 
ATOM   5819 O OD2 . ASP C 1 268 ? 122.948 122.258 147.222 1.00 21.04  ? 339 ASP E OD2 1 
ATOM   5820 N N   . ILE C 1 269 ? 123.573 127.341 150.126 1.00 19.02  ? 340 ILE E N   1 
ATOM   5821 C CA  . ILE C 1 269 ? 123.378 128.106 151.353 1.00 19.02  ? 340 ILE E CA  1 
ATOM   5822 C C   . ILE C 1 269 ? 122.724 129.427 150.975 1.00 19.02  ? 340 ILE E C   1 
ATOM   5823 O O   . ILE C 1 269 ? 122.907 129.928 149.863 1.00 19.02  ? 340 ILE E O   1 
ATOM   5824 C CB  . ILE C 1 269 ? 124.721 128.315 152.101 1.00 19.02  ? 340 ILE E CB  1 
ATOM   5825 C CG1 . ILE C 1 269 ? 124.481 128.846 153.515 1.00 19.02  ? 340 ILE E CG1 1 
ATOM   5826 C CG2 . ILE C 1 269 ? 125.633 129.251 151.320 1.00 19.02  ? 340 ILE E CG2 1 
ATOM   5827 C CD1 . ILE C 1 269 ? 125.746 128.984 154.326 1.00 19.02  ? 340 ILE E CD1 1 
ATOM   5828 N N   . SER C 1 270 ? 121.943 129.986 151.901 1.00 17.45  ? 341 SER E N   1 
ATOM   5829 C CA  . SER C 1 270 ? 121.299 131.273 151.671 1.00 17.45  ? 341 SER E CA  1 
ATOM   5830 C C   . SER C 1 270 ? 121.425 132.145 152.912 1.00 17.45  ? 341 SER E C   1 
ATOM   5831 O O   . SER C 1 270 ? 121.437 131.646 154.040 1.00 17.45  ? 341 SER E O   1 
ATOM   5832 C CB  . SER C 1 270 ? 119.821 131.109 151.292 1.00 17.45  ? 341 SER E CB  1 
ATOM   5833 O OG  . SER C 1 270 ? 119.097 130.457 152.319 1.00 17.45  ? 341 SER E OG  1 
ATOM   5834 N N   . VAL C 1 271 ? 121.519 133.456 152.691 1.00 16.88  ? 342 VAL E N   1 
ATOM   5835 C CA  . VAL C 1 271 ? 121.694 134.437 153.758 1.00 16.88  ? 342 VAL E CA  1 
ATOM   5836 C C   . VAL C 1 271 ? 120.669 135.548 153.573 1.00 16.88  ? 342 VAL E C   1 
ATOM   5837 O O   . VAL C 1 271 ? 120.499 136.061 152.461 1.00 16.88  ? 342 VAL E O   1 
ATOM   5838 C CB  . VAL C 1 271 ? 123.120 135.021 153.771 1.00 16.88  ? 342 VAL E CB  1 
ATOM   5839 C CG1 . VAL C 1 271 ? 123.290 135.991 154.931 1.00 16.88  ? 342 VAL E CG1 1 
ATOM   5840 C CG2 . VAL C 1 271 ? 124.156 133.909 153.842 1.00 16.88  ? 342 VAL E CG2 1 
ATOM   5841 N N   . GLN C 1 272 ? 119.994 135.923 154.660 1.00 22.42  ? 343 GLN E N   1 
ATOM   5842 C CA  . GLN C 1 272 ? 119.012 136.999 154.641 1.00 22.42  ? 343 GLN E CA  1 
ATOM   5843 C C   . GLN C 1 272 ? 119.071 137.744 155.971 1.00 22.42  ? 343 GLN E C   1 
ATOM   5844 O O   . GLN C 1 272 ? 119.852 137.405 156.863 1.00 22.42  ? 343 GLN E O   1 
ATOM   5845 C CB  . GLN C 1 272 ? 117.601 136.463 154.373 1.00 22.42  ? 343 GLN E CB  1 
ATOM   5846 C CG  . GLN C 1 272 ? 117.322 136.117 152.920 1.00 22.42  ? 343 GLN E CG  1 
ATOM   5847 C CD  . GLN C 1 272 ? 115.935 135.541 152.717 1.00 22.42  ? 343 GLN E CD  1 
ATOM   5848 O OE1 . GLN C 1 272 ? 115.413 134.831 153.577 1.00 22.42  ? 343 GLN E OE1 1 
ATOM   5849 N NE2 . GLN C 1 272 ? 115.328 135.847 151.577 1.00 22.42  ? 343 GLN E NE2 1 
ATOM   5850 N N   . TRP C 1 273 ? 118.227 138.766 156.099 1.00 30.42  ? 344 TRP E N   1 
ATOM   5851 C CA  . TRP C 1 273 ? 118.097 139.536 157.327 1.00 30.42  ? 344 TRP E CA  1 
ATOM   5852 C C   . TRP C 1 273 ? 116.623 139.703 157.664 1.00 30.42  ? 344 TRP E C   1 
ATOM   5853 O O   . TRP C 1 273 ? 115.770 139.746 156.773 1.00 30.42  ? 344 TRP E O   1 
ATOM   5854 C CB  . TRP C 1 273 ? 118.764 140.914 157.204 1.00 30.42  ? 344 TRP E CB  1 
ATOM   5855 C CG  . TRP C 1 273 ? 120.259 140.858 157.133 1.00 30.42  ? 344 TRP E CG  1 
ATOM   5856 C CD1 . TRP C 1 273 ? 121.015 140.467 156.067 1.00 30.42  ? 344 TRP E CD1 1 
ATOM   5857 C CD2 . TRP C 1 273 ? 121.182 141.214 158.170 1.00 30.42  ? 344 TRP E CD2 1 
ATOM   5858 N NE1 . TRP C 1 273 ? 122.351 140.552 156.377 1.00 30.42  ? 344 TRP E NE1 1 
ATOM   5859 C CE2 . TRP C 1 273 ? 122.480 141.008 157.662 1.00 30.42  ? 344 TRP E CE2 1 
ATOM   5860 C CE3 . TRP C 1 273 ? 121.036 141.683 159.479 1.00 30.42  ? 344 TRP E CE3 1 
ATOM   5861 C CZ2 . TRP C 1 273 ? 123.625 141.257 158.416 1.00 30.42  ? 344 TRP E CZ2 1 
ATOM   5862 C CZ3 . TRP C 1 273 ? 122.175 141.929 160.227 1.00 30.42  ? 344 TRP E CZ3 1 
ATOM   5863 C CH2 . TRP C 1 273 ? 123.452 141.715 159.693 1.00 30.42  ? 344 TRP E CH2 1 
ATOM   5864 N N   . LEU C 1 274 ? 116.326 139.794 158.959 1.00 38.09  ? 345 LEU E N   1 
ATOM   5865 C CA  . LEU C 1 274 ? 114.950 139.936 159.434 1.00 38.09  ? 345 LEU E CA  1 
ATOM   5866 C C   . LEU C 1 274 ? 114.844 141.073 160.445 1.00 38.09  ? 345 LEU E C   1 
ATOM   5867 O O   . LEU C 1 274 ? 114.247 140.939 161.515 1.00 38.09  ? 345 LEU E O   1 
ATOM   5868 C CB  . LEU C 1 274 ? 114.425 138.629 160.030 1.00 38.09  ? 345 LEU E CB  1 
ATOM   5869 C CG  . LEU C 1 274 ? 115.205 137.953 161.159 1.00 38.09  ? 345 LEU E CG  1 
ATOM   5870 C CD1 . LEU C 1 274 ? 114.255 137.228 162.096 1.00 38.09  ? 345 LEU E CD1 1 
ATOM   5871 C CD2 . LEU C 1 274 ? 116.225 136.986 160.594 1.00 38.09  ? 345 LEU E CD2 1 
ATOM   5872 N N   . GLY C 1 275 ? 115.425 142.222 160.106 1.00 45.22  ? 346 GLY E N   1 
ATOM   5873 C CA  . GLY C 1 275 ? 115.383 143.376 160.983 1.00 45.22  ? 346 GLY E CA  1 
ATOM   5874 C C   . GLY C 1 275 ? 113.986 143.905 161.245 1.00 45.22  ? 346 GLY E C   1 
ATOM   5875 O O   . GLY C 1 275 ? 113.341 144.452 160.345 1.00 45.22  ? 346 GLY E O   1 
ATOM   5876 N N   . ASP C 1 276 ? 113.515 143.743 162.484 1.00 49.72  ? 347 ASP E N   1 
ATOM   5877 C CA  . ASP C 1 276 ? 112.210 144.237 162.929 1.00 49.72  ? 347 ASP E CA  1 
ATOM   5878 C C   . ASP C 1 276 ? 111.072 143.667 162.079 1.00 49.72  ? 347 ASP E C   1 
ATOM   5879 O O   . ASP C 1 276 ? 110.346 144.390 161.393 1.00 49.72  ? 347 ASP E O   1 
ATOM   5880 C CB  . ASP C 1 276 ? 112.174 145.769 162.941 1.00 49.72  ? 347 ASP E CB  1 
ATOM   5881 C CG  . ASP C 1 276 ? 112.880 146.360 164.144 1.00 49.72  ? 347 ASP E CG  1 
ATOM   5882 O OD1 . ASP C 1 276 ? 113.619 145.620 164.827 1.00 49.72  ? 347 ASP E OD1 1 
ATOM   5883 O OD2 . ASP C 1 276 ? 112.685 147.563 164.415 1.00 49.72  ? 347 ASP E OD2 1 
ATOM   5884 N N   . GLY C 1 277 ? 110.927 142.346 162.136 1.00 46.06  ? 348 GLY E N   1 
ATOM   5885 C CA  . GLY C 1 277 ? 109.800 141.695 161.498 1.00 46.06  ? 348 GLY E CA  1 
ATOM   5886 C C   . GLY C 1 277 ? 110.029 141.345 160.043 1.00 46.06  ? 348 GLY E C   1 
ATOM   5887 O O   . GLY C 1 277 ? 110.627 140.311 159.731 1.00 46.06  ? 348 GLY E O   1 
ATOM   5888 N N   . LYS C 1 278 ? 109.540 142.200 159.146 1.00 45.41  ? 349 LYS E N   1 
ATOM   5889 C CA  . LYS C 1 278 ? 109.657 141.944 157.716 1.00 45.41  ? 349 LYS E CA  1 
ATOM   5890 C C   . LYS C 1 278 ? 111.121 141.860 157.302 1.00 45.41  ? 349 LYS E C   1 
ATOM   5891 O O   . LYS C 1 278 ? 111.970 142.609 157.795 1.00 45.41  ? 349 LYS E O   1 
ATOM   5892 C CB  . LYS C 1 278 ? 108.947 143.040 156.917 1.00 45.41  ? 349 LYS E CB  1 
ATOM   5893 C CG  . LYS C 1 278 ? 107.433 142.881 156.814 1.00 45.41  ? 349 LYS E CG  1 
ATOM   5894 C CD  . LYS C 1 278 ? 106.726 143.241 158.112 1.00 45.41  ? 349 LYS E CD  1 
ATOM   5895 C CE  . LYS C 1 278 ? 107.011 144.678 158.517 1.00 45.41  ? 349 LYS E CE  1 
ATOM   5896 N NZ  . LYS C 1 278 ? 106.333 145.039 159.793 1.00 45.41  ? 349 LYS E NZ  1 
ATOM   5897 N N   . LEU C 1 279 ? 111.411 140.934 156.393 1.00 42.15  ? 350 LEU E N   1 
ATOM   5898 C CA  . LEU C 1 279 ? 112.780 140.720 155.946 1.00 42.15  ? 350 LEU E CA  1 
ATOM   5899 C C   . LEU C 1 279 ? 113.291 141.930 155.174 1.00 42.15  ? 350 LEU E C   1 
ATOM   5900 O O   . LEU C 1 279 ? 112.545 142.578 154.434 1.00 42.15  ? 350 LEU E O   1 
ATOM   5901 C CB  . LEU C 1 279 ? 112.868 139.466 155.074 1.00 42.15  ? 350 LEU E CB  1 
ATOM   5902 C CG  . LEU C 1 279 ? 112.938 138.100 155.768 1.00 42.15  ? 350 LEU E CG  1 
ATOM   5903 C CD1 . LEU C 1 279 ? 111.637 137.748 156.477 1.00 42.15  ? 350 LEU E CD1 1 
ATOM   5904 C CD2 . LEU C 1 279 ? 113.310 137.018 154.766 1.00 42.15  ? 350 LEU E CD2 1 
ATOM   5905 N N   . ILE C 1 280 ? 114.575 142.234 155.357 1.00 42.76  ? 351 ILE E N   1 
ATOM   5906 C CA  . ILE C 1 280 ? 115.190 143.360 154.665 1.00 42.76  ? 351 ILE E CA  1 
ATOM   5907 C C   . ILE C 1 280 ? 115.282 143.048 153.178 1.00 42.76  ? 351 ILE E C   1 
ATOM   5908 O O   . ILE C 1 280 ? 115.672 141.942 152.781 1.00 42.76  ? 351 ILE E O   1 
ATOM   5909 C CB  . ILE C 1 280 ? 116.572 143.667 155.259 1.00 42.76  ? 351 ILE E CB  1 
ATOM   5910 C CG1 . ILE C 1 280 ? 116.460 143.921 156.764 1.00 42.76  ? 351 ILE E CG1 1 
ATOM   5911 C CG2 . ILE C 1 280 ? 117.200 144.865 154.564 1.00 42.76  ? 351 ILE E CG2 1 
ATOM   5912 C CD1 . ILE C 1 280 ? 115.569 145.090 157.121 1.00 42.76  ? 351 ILE E CD1 1 
ATOM   5913 N N   . SER C 1 281 ? 114.915 144.022 152.348 1.00 44.33  ? 352 SER E N   1 
ATOM   5914 C CA  . SER C 1 281 ? 114.959 143.834 150.906 1.00 44.33  ? 352 SER E CA  1 
ATOM   5915 C C   . SER C 1 281 ? 116.395 143.643 150.433 1.00 44.33  ? 352 SER E C   1 
ATOM   5916 O O   . SER C 1 281 ? 117.344 144.174 151.017 1.00 44.33  ? 352 SER E O   1 
ATOM   5917 C CB  . SER C 1 281 ? 114.325 145.028 150.192 1.00 44.33  ? 352 SER E CB  1 
ATOM   5918 O OG  . SER C 1 281 ? 115.014 146.229 150.497 1.00 44.33  ? 352 SER E OG  1 
ATOM   5919 N N   . ASN C 1 282 ? 116.549 142.867 149.358 1.00 44.36  ? 353 ASN E N   1 
ATOM   5920 C CA  . ASN C 1 282 ? 117.869 142.568 148.818 1.00 44.36  ? 353 ASN E CA  1 
ATOM   5921 C C   . ASN C 1 282 ? 118.549 143.785 148.204 1.00 44.36  ? 353 ASN E C   1 
ATOM   5922 O O   . ASN C 1 282 ? 119.756 143.733 147.947 1.00 44.36  ? 353 ASN E O   1 
ATOM   5923 C CB  . ASN C 1 282 ? 117.762 141.450 147.776 1.00 44.36  ? 353 ASN E CB  1 
ATOM   5924 C CG  . ASN C 1 282 ? 119.108 140.842 147.430 1.00 44.36  ? 353 ASN E CG  1 
ATOM   5925 O OD1 . ASN C 1 282 ? 120.049 140.895 148.222 1.00 44.36  ? 353 ASN E OD1 1 
ATOM   5926 N ND2 . ASN C 1 282 ? 119.205 140.260 146.240 1.00 44.36  ? 353 ASN E ND2 1 
ATOM   5927 N N   . SER C 1 283 ? 117.811 144.871 147.960 1.00 42.37  ? 354 SER E N   1 
ATOM   5928 C CA  . SER C 1 283 ? 118.422 146.070 147.394 1.00 42.37  ? 354 SER E CA  1 
ATOM   5929 C C   . SER C 1 283 ? 119.441 146.676 148.353 1.00 42.37  ? 354 SER E C   1 
ATOM   5930 O O   . SER C 1 283 ? 120.545 147.052 147.944 1.00 42.37  ? 354 SER E O   1 
ATOM   5931 C CB  . SER C 1 283 ? 117.339 147.088 147.036 1.00 42.37  ? 354 SER E CB  1 
ATOM   5932 O OG  . SER C 1 283 ? 116.504 147.358 148.147 1.00 42.37  ? 354 SER E OG  1 
ATOM   5933 N N   . GLN C 1 284 ? 119.089 146.779 149.632 1.00 38.98  ? 355 GLN E N   1 
ATOM   5934 C CA  . GLN C 1 284 ? 120.009 147.292 150.649 1.00 38.98  ? 355 GLN E CA  1 
ATOM   5935 C C   . GLN C 1 284 ? 120.775 146.161 151.329 1.00 38.98  ? 355 GLN E C   1 
ATOM   5936 O O   . GLN C 1 284 ? 120.821 146.062 152.555 1.00 38.98  ? 355 GLN E O   1 
ATOM   5937 C CB  . GLN C 1 284 ? 119.248 148.128 151.671 1.00 38.98  ? 355 GLN E CB  1 
ATOM   5938 C CG  . GLN C 1 284 ? 118.718 149.454 151.141 1.00 38.98  ? 355 GLN E CG  1 
ATOM   5939 C CD  . GLN C 1 284 ? 117.449 149.299 150.325 1.00 38.98  ? 355 GLN E CD  1 
ATOM   5940 O OE1 . GLN C 1 284 ? 116.863 148.218 150.265 1.00 38.98  ? 355 GLN E OE1 1 
ATOM   5941 N NE2 . GLN C 1 284 ? 117.018 150.383 149.690 1.00 38.98  ? 355 GLN E NE2 1 
ATOM   5942 N N   . HIS C 1 285 ? 121.394 145.303 150.523 1.00 28.38  ? 356 HIS E N   1 
ATOM   5943 C CA  . HIS C 1 285 ? 122.138 144.151 151.016 1.00 28.38  ? 356 HIS E CA  1 
ATOM   5944 C C   . HIS C 1 285 ? 122.911 143.544 149.856 1.00 28.38  ? 356 HIS E C   1 
ATOM   5945 O O   . HIS C 1 285 ? 122.459 143.587 148.708 1.00 28.38  ? 356 HIS E O   1 
ATOM   5946 C CB  . HIS C 1 285 ? 121.205 143.104 151.641 1.00 28.38  ? 356 HIS E CB  1 
ATOM   5947 C CG  . HIS C 1 285 ? 121.917 141.897 152.169 1.00 28.38  ? 356 HIS E CG  1 
ATOM   5948 N ND1 . HIS C 1 285 ? 122.071 140.742 151.433 1.00 28.38  ? 356 HIS E ND1 1 
ATOM   5949 C CD2 . HIS C 1 285 ? 122.516 141.666 153.361 1.00 28.38  ? 356 HIS E CD2 1 
ATOM   5950 C CE1 . HIS C 1 285 ? 122.734 139.852 152.148 1.00 28.38  ? 356 HIS E CE1 1 
ATOM   5951 N NE2 . HIS C 1 285 ? 123.015 140.387 153.323 1.00 28.38  ? 356 HIS E NE2 1 
ATOM   5952 N N   . SER C 1 286 ? 124.078 142.984 150.164 1.00 21.75  ? 357 SER E N   1 
ATOM   5953 C CA  . SER C 1 286 ? 124.875 142.318 149.146 1.00 21.75  ? 357 SER E CA  1 
ATOM   5954 C C   . SER C 1 286 ? 125.609 141.145 149.775 1.00 21.75  ? 357 SER E C   1 
ATOM   5955 O O   . SER C 1 286 ? 125.861 141.120 150.982 1.00 21.75  ? 357 SER E O   1 
ATOM   5956 C CB  . SER C 1 286 ? 125.867 143.281 148.483 1.00 21.75  ? 357 SER E CB  1 
ATOM   5957 O OG  . SER C 1 286 ? 126.515 142.662 147.386 1.00 21.75  ? 357 SER E OG  1 
ATOM   5958 N N   . THR C 1 287 ? 125.947 140.165 148.939 1.00 18.95  ? 358 THR E N   1 
ATOM   5959 C CA  . THR C 1 287 ? 126.659 138.971 149.373 1.00 18.95  ? 358 THR E CA  1 
ATOM   5960 C C   . THR C 1 287 ? 127.846 138.737 148.452 1.00 18.95  ? 358 THR E C   1 
ATOM   5961 O O   . THR C 1 287 ? 127.692 138.729 147.226 1.00 18.95  ? 358 THR E O   1 
ATOM   5962 C CB  . THR C 1 287 ? 125.740 137.743 149.374 1.00 18.95  ? 358 THR E CB  1 
ATOM   5963 O OG1 . THR C 1 287 ? 124.624 137.980 150.242 1.00 18.95  ? 358 THR E OG1 1 
ATOM   5964 C CG2 . THR C 1 287 ? 126.494 136.511 149.852 1.00 18.95  ? 358 THR E CG2 1 
ATOM   5965 N N   . THR C 1 288 ? 129.023 138.549 149.042 1.00 16.33  ? 359 THR E N   1 
ATOM   5966 C CA  . THR C 1 288 ? 130.223 138.302 148.259 1.00 16.33  ? 359 THR E CA  1 
ATOM   5967 C C   . THR C 1 288 ? 130.188 136.903 147.648 1.00 16.33  ? 359 THR E C   1 
ATOM   5968 O O   . THR C 1 288 ? 129.505 135.997 148.132 1.00 16.33  ? 359 THR E O   1 
ATOM   5969 C CB  . THR C 1 288 ? 131.474 138.461 149.124 1.00 16.33  ? 359 THR E CB  1 
ATOM   5970 O OG1 . THR C 1 288 ? 131.434 137.519 150.204 1.00 16.33  ? 359 THR E OG1 1 
ATOM   5971 C CG2 . THR C 1 288 ? 131.554 139.871 149.690 1.00 16.33  ? 359 THR E CG2 1 
ATOM   5972 N N   . THR C 1 289 ? 130.938 136.739 146.562 1.00 19.24  ? 360 THR E N   1 
ATOM   5973 C CA  . THR C 1 289 ? 131.016 135.444 145.906 1.00 19.24  ? 360 THR E CA  1 
ATOM   5974 C C   . THR C 1 289 ? 131.725 134.440 146.813 1.00 19.24  ? 360 THR E C   1 
ATOM   5975 O O   . THR C 1 289 ? 132.673 134.800 147.517 1.00 19.24  ? 360 THR E O   1 
ATOM   5976 C CB  . THR C 1 289 ? 131.757 135.556 144.574 1.00 19.24  ? 360 THR E CB  1 
ATOM   5977 O OG1 . THR C 1 289 ? 133.089 136.033 144.804 1.00 19.24  ? 360 THR E OG1 1 
ATOM   5978 C CG2 . THR C 1 289 ? 131.034 136.516 143.641 1.00 19.24  ? 360 THR E CG2 1 
ATOM   5979 N N   . PRO C 1 290 ? 131.285 133.182 146.828 1.00 16.92  ? 361 PRO E N   1 
ATOM   5980 C CA  . PRO C 1 290 ? 131.935 132.184 147.689 1.00 16.92  ? 361 PRO E CA  1 
ATOM   5981 C C   . PRO C 1 290 ? 133.329 131.843 147.182 1.00 16.92  ? 361 PRO E C   1 
ATOM   5982 O O   . PRO C 1 290 ? 133.529 131.585 145.993 1.00 16.92  ? 361 PRO E O   1 
ATOM   5983 C CB  . PRO C 1 290 ? 130.994 130.974 147.608 1.00 16.92  ? 361 PRO E CB  1 
ATOM   5984 C CG  . PRO C 1 290 ? 129.695 131.520 147.088 1.00 16.92  ? 361 PRO E CG  1 
ATOM   5985 C CD  . PRO C 1 290 ? 130.074 132.649 146.184 1.00 16.92  ? 361 PRO E CD  1 
ATOM   5986 N N   . LEU C 1 291 ? 134.293 131.843 148.099 1.00 20.09  ? 362 LEU E N   1 
ATOM   5987 C CA  . LEU C 1 291 ? 135.671 131.474 147.806 1.00 20.09  ? 362 LEU E CA  1 
ATOM   5988 C C   . LEU C 1 291 ? 136.079 130.305 148.691 1.00 20.09  ? 362 LEU E C   1 
ATOM   5989 O O   . LEU C 1 291 ? 135.644 130.206 149.843 1.00 20.09  ? 362 LEU E O   1 
ATOM   5990 C CB  . LEU C 1 291 ? 136.628 132.653 148.022 1.00 20.09  ? 362 LEU E CB  1 
ATOM   5991 C CG  . LEU C 1 291 ? 136.918 133.567 146.828 1.00 20.09  ? 362 LEU E CG  1 
ATOM   5992 C CD1 . LEU C 1 291 ? 135.669 134.302 146.366 1.00 20.09  ? 362 LEU E CD1 1 
ATOM   5993 C CD2 . LEU C 1 291 ? 138.027 134.553 147.167 1.00 20.09  ? 362 LEU E CD2 1 
ATOM   5994 N N   . LYS C 1 292 ? 136.911 129.420 148.148 1.00 27.77  ? 363 LYS E N   1 
ATOM   5995 C CA  . LYS C 1 292 ? 137.351 128.252 148.898 1.00 27.77  ? 363 LYS E CA  1 
ATOM   5996 C C   . LYS C 1 292 ? 138.313 128.665 150.005 1.00 27.77  ? 363 LYS E C   1 
ATOM   5997 O O   . LYS C 1 292 ? 139.288 129.383 149.761 1.00 27.77  ? 363 LYS E O   1 
ATOM   5998 C CB  . LYS C 1 292 ? 138.015 127.242 147.963 1.00 27.77  ? 363 LYS E CB  1 
ATOM   5999 C CG  . LYS C 1 292 ? 138.481 125.970 148.653 1.00 27.77  ? 363 LYS E CG  1 
ATOM   6000 C CD  . LYS C 1 292 ? 139.029 124.967 147.651 1.00 27.77  ? 363 LYS E CD  1 
ATOM   6001 C CE  . LYS C 1 292 ? 140.191 125.549 146.863 1.00 27.77  ? 363 LYS E CE  1 
ATOM   6002 N NZ  . LYS C 1 292 ? 141.316 125.952 147.750 1.00 27.77  ? 363 LYS E NZ  1 
ATOM   6003 N N   . SER C 1 293 ? 138.036 128.209 151.223 1.00 29.38  ? 364 SER E N   1 
ATOM   6004 C CA  . SER C 1 293 ? 138.882 128.524 152.365 1.00 29.38  ? 364 SER E CA  1 
ATOM   6005 C C   . SER C 1 293 ? 140.156 127.691 152.318 1.00 29.38  ? 364 SER E C   1 
ATOM   6006 O O   . SER C 1 293 ? 140.105 126.472 152.124 1.00 29.38  ? 364 SER E O   1 
ATOM   6007 C CB  . SER C 1 293 ? 138.130 128.271 153.672 1.00 29.38  ? 364 SER E CB  1 
ATOM   6008 O OG  . SER C 1 293 ? 138.941 128.575 154.794 1.00 29.38  ? 364 SER E OG  1 
ATOM   6009 N N   . ASN C 1 294 ? 141.298 128.350 152.495 1.00 36.14  ? 365 ASN E N   1 
ATOM   6010 C CA  . ASN C 1 294 ? 142.581 127.662 152.483 1.00 36.14  ? 365 ASN E CA  1 
ATOM   6011 C C   . ASN C 1 294 ? 142.815 126.976 153.823 1.00 36.14  ? 365 ASN E C   1 
ATOM   6012 O O   . ASN C 1 294 ? 142.719 127.607 154.880 1.00 36.14  ? 365 ASN E O   1 
ATOM   6013 C CB  . ASN C 1 294 ? 143.711 128.646 152.184 1.00 36.14  ? 365 ASN E CB  1 
ATOM   6014 C CG  . ASN C 1 294 ? 145.059 127.964 152.052 1.00 36.14  ? 365 ASN E CG  1 
ATOM   6015 O OD1 . ASN C 1 294 ? 145.138 126.768 151.772 1.00 36.14  ? 365 ASN E OD1 1 
ATOM   6016 N ND2 . ASN C 1 294 ? 146.129 128.725 152.253 1.00 36.14  ? 365 ASN E ND2 1 
ATOM   6017 N N   . GLY C 1 295 ? 143.125 125.682 153.775 1.00 40.39  ? 366 GLY E N   1 
ATOM   6018 C CA  . GLY C 1 295 ? 143.349 124.937 154.996 1.00 40.39  ? 366 GLY E CA  1 
ATOM   6019 C C   . GLY C 1 295 ? 142.061 124.705 155.772 1.00 40.39  ? 366 GLY E C   1 
ATOM   6020 O O   . GLY C 1 295 ? 140.951 124.729 155.230 1.00 40.39  ? 366 GLY E O   1 
ATOM   6021 N N   . SER C 1 296 ? 142.233 124.479 157.077 1.00 40.24  ? 367 SER E N   1 
ATOM   6022 C CA  . SER C 1 296 ? 141.132 124.231 158.003 1.00 40.24  ? 367 SER E CA  1 
ATOM   6023 C C   . SER C 1 296 ? 140.268 123.063 157.544 1.00 40.24  ? 367 SER E C   1 
ATOM   6024 O O   . SER C 1 296 ? 140.640 121.898 157.724 1.00 40.24  ? 367 SER E O   1 
ATOM   6025 C CB  . SER C 1 296 ? 140.272 125.488 158.176 1.00 40.24  ? 367 SER E CB  1 
ATOM   6026 O OG  . SER C 1 296 ? 139.554 125.791 156.992 1.00 40.24  ? 367 SER E OG  1 
ATOM   6027 N N   . ASN C 1 297 ? 139.118 123.363 156.953 1.00 42.58  ? 368 ASN E N   1 
ATOM   6028 C CA  . ASN C 1 297 ? 138.173 122.355 156.495 1.00 42.58  ? 368 ASN E CA  1 
ATOM   6029 C C   . ASN C 1 297 ? 137.952 122.508 154.989 1.00 42.58  ? 368 ASN E C   1 
ATOM   6030 O O   . ASN C 1 297 ? 138.607 123.310 154.319 1.00 42.58  ? 368 ASN E O   1 
ATOM   6031 C CB  . ASN C 1 297 ? 136.860 122.462 157.274 1.00 42.58  ? 368 ASN E CB  1 
ATOM   6032 C CG  . ASN C 1 297 ? 137.052 122.277 158.766 1.00 42.58  ? 368 ASN E CG  1 
ATOM   6033 O OD1 . ASN C 1 297 ? 137.955 121.565 159.205 1.00 42.58  ? 368 ASN E OD1 1 
ATOM   6034 N ND2 . ASN C 1 297 ? 136.200 122.921 159.557 1.00 42.58  ? 368 ASN E ND2 1 
ATOM   6035 N N   . GLN C 1 298 ? 137.014 121.725 154.462 1.00 44.87  ? 369 GLN E N   1 
ATOM   6036 C CA  . GLN C 1 298 ? 136.693 121.736 153.041 1.00 44.87  ? 369 GLN E CA  1 
ATOM   6037 C C   . GLN C 1 298 ? 135.589 122.725 152.689 1.00 44.87  ? 369 GLN E C   1 
ATOM   6038 O O   . GLN C 1 298 ? 135.209 122.814 151.517 1.00 44.87  ? 369 GLN E O   1 
ATOM   6039 C CB  . GLN C 1 298 ? 136.288 120.331 152.584 1.00 44.87  ? 369 GLN E CB  1 
ATOM   6040 C CG  . GLN C 1 298 ? 137.318 119.257 152.891 1.00 44.87  ? 369 GLN E CG  1 
ATOM   6041 C CD  . GLN C 1 298 ? 136.848 117.871 152.499 1.00 44.87  ? 369 GLN E CD  1 
ATOM   6042 O OE1 . GLN C 1 298 ? 135.806 117.712 151.865 1.00 44.87  ? 369 GLN E OE1 1 
ATOM   6043 N NE2 . GLN C 1 298 ? 137.617 116.856 152.879 1.00 44.87  ? 369 GLN E NE2 1 
ATOM   6044 N N   . GLY C 1 299 ? 135.069 123.465 153.666 1.00 26.53  ? 370 GLY E N   1 
ATOM   6045 C CA  . GLY C 1 299 ? 133.994 124.399 153.420 1.00 26.53  ? 370 GLY E CA  1 
ATOM   6046 C C   . GLY C 1 299 ? 134.472 125.705 152.815 1.00 26.53  ? 370 GLY E C   1 
ATOM   6047 O O   . GLY C 1 299 ? 135.661 125.938 152.596 1.00 26.53  ? 370 GLY E O   1 
ATOM   6048 N N   . PHE C 1 300 ? 133.507 126.575 152.541 1.00 20.99  ? 371 PHE E N   1 
ATOM   6049 C CA  . PHE C 1 300 ? 133.743 127.887 151.959 1.00 20.99  ? 371 PHE E CA  1 
ATOM   6050 C C   . PHE C 1 300 ? 133.494 128.968 153.008 1.00 20.99  ? 371 PHE E C   1 
ATOM   6051 O O   . PHE C 1 300 ? 133.110 128.689 154.148 1.00 20.99  ? 371 PHE E O   1 
ATOM   6052 C CB  . PHE C 1 300 ? 132.853 128.099 150.730 1.00 20.99  ? 371 PHE E CB  1 
ATOM   6053 C CG  . PHE C 1 300 ? 133.169 127.182 149.581 1.00 20.99  ? 371 PHE E CG  1 
ATOM   6054 C CD1 . PHE C 1 300 ? 132.708 125.876 149.569 1.00 20.99  ? 371 PHE E CD1 1 
ATOM   6055 C CD2 . PHE C 1 300 ? 133.916 127.632 148.506 1.00 20.99  ? 371 PHE E CD2 1 
ATOM   6056 C CE1 . PHE C 1 300 ? 132.996 125.033 148.511 1.00 20.99  ? 371 PHE E CE1 1 
ATOM   6057 C CE2 . PHE C 1 300 ? 134.207 126.795 147.445 1.00 20.99  ? 371 PHE E CE2 1 
ATOM   6058 C CZ  . PHE C 1 300 ? 133.746 125.494 147.448 1.00 20.99  ? 371 PHE E CZ  1 
ATOM   6059 N N   . PHE C 1 301 ? 133.721 130.219 152.612 1.00 18.84  ? 372 PHE E N   1 
ATOM   6060 C CA  . PHE C 1 301 ? 133.460 131.365 153.470 1.00 18.84  ? 372 PHE E CA  1 
ATOM   6061 C C   . PHE C 1 301 ? 132.835 132.478 152.643 1.00 18.84  ? 372 PHE E C   1 
ATOM   6062 O O   . PHE C 1 301 ? 133.265 132.741 151.516 1.00 18.84  ? 372 PHE E O   1 
ATOM   6063 C CB  . PHE C 1 301 ? 134.743 131.864 154.155 1.00 18.84  ? 372 PHE E CB  1 
ATOM   6064 C CG  . PHE C 1 301 ? 135.788 132.372 153.200 1.00 18.84  ? 372 PHE E CG  1 
ATOM   6065 C CD1 . PHE C 1 301 ? 136.664 131.497 152.581 1.00 18.84  ? 372 PHE E CD1 1 
ATOM   6066 C CD2 . PHE C 1 301 ? 135.900 133.727 152.932 1.00 18.84  ? 372 PHE E CD2 1 
ATOM   6067 C CE1 . PHE C 1 301 ? 137.627 131.961 151.705 1.00 18.84  ? 372 PHE E CE1 1 
ATOM   6068 C CE2 . PHE C 1 301 ? 136.861 134.197 152.057 1.00 18.84  ? 372 PHE E CE2 1 
ATOM   6069 C CZ  . PHE C 1 301 ? 137.725 133.313 151.443 1.00 18.84  ? 372 PHE E CZ  1 
ATOM   6070 N N   . ILE C 1 302 ? 131.813 133.122 153.204 1.00 15.90  ? 373 ILE E N   1 
ATOM   6071 C CA  . ILE C 1 302 ? 131.116 134.216 152.541 1.00 15.90  ? 373 ILE E CA  1 
ATOM   6072 C C   . ILE C 1 302 ? 130.902 135.351 153.532 1.00 15.90  ? 373 ILE E C   1 
ATOM   6073 O O   . ILE C 1 302 ? 130.804 135.139 154.746 1.00 15.90  ? 373 ILE E O   1 
ATOM   6074 C CB  . ILE C 1 302 ? 129.765 133.767 151.940 1.00 15.90  ? 373 ILE E CB  1 
ATOM   6075 C CG1 . ILE C 1 302 ? 128.905 133.081 153.004 1.00 15.90  ? 373 ILE E CG1 1 
ATOM   6076 C CG2 . ILE C 1 302 ? 129.983 132.853 150.744 1.00 15.90  ? 373 ILE E CG2 1 
ATOM   6077 C CD1 . ILE C 1 302 ? 127.555 132.625 152.497 1.00 15.90  ? 373 ILE E CD1 1 
ATOM   6078 N N   . PHE C 1 303 ? 130.829 136.567 152.997 1.00 16.47  ? 374 PHE E N   1 
ATOM   6079 C CA  . PHE C 1 303 ? 130.536 137.769 153.765 1.00 16.47  ? 374 PHE E CA  1 
ATOM   6080 C C   . PHE C 1 303 ? 129.317 138.445 153.157 1.00 16.47  ? 374 PHE E C   1 
ATOM   6081 O O   . PHE C 1 303 ? 129.232 138.591 151.933 1.00 16.47  ? 374 PHE E O   1 
ATOM   6082 C CB  . PHE C 1 303 ? 131.722 138.739 153.764 1.00 16.47  ? 374 PHE E CB  1 
ATOM   6083 C CG  . PHE C 1 303 ? 132.963 138.195 154.414 1.00 16.47  ? 374 PHE E CG  1 
ATOM   6084 C CD1 . PHE C 1 303 ? 133.826 137.370 153.712 1.00 16.47  ? 374 PHE E CD1 1 
ATOM   6085 C CD2 . PHE C 1 303 ? 133.279 138.528 155.721 1.00 16.47  ? 374 PHE E CD2 1 
ATOM   6086 C CE1 . PHE C 1 303 ? 134.972 136.875 154.305 1.00 16.47  ? 374 PHE E CE1 1 
ATOM   6087 C CE2 . PHE C 1 303 ? 134.424 138.039 156.319 1.00 16.47  ? 374 PHE E CE2 1 
ATOM   6088 C CZ  . PHE C 1 303 ? 135.272 137.211 155.611 1.00 16.47  ? 374 PHE E CZ  1 
ATOM   6089 N N   . SER C 1 304 ? 128.378 138.857 154.005 1.00 19.22  ? 375 SER E N   1 
ATOM   6090 C CA  . SER C 1 304 ? 127.211 139.612 153.572 1.00 19.22  ? 375 SER E CA  1 
ATOM   6091 C C   . SER C 1 304 ? 127.237 140.979 154.238 1.00 19.22  ? 375 SER E C   1 
ATOM   6092 O O   . SER C 1 304 ? 127.389 141.078 155.461 1.00 19.22  ? 375 SER E O   1 
ATOM   6093 C CB  . SER C 1 304 ? 125.913 138.871 153.905 1.00 19.22  ? 375 SER E CB  1 
ATOM   6094 O OG  . SER C 1 304 ? 125.809 138.619 155.292 1.00 19.22  ? 375 SER E OG  1 
ATOM   6095 N N   . ARG C 1 305 ? 127.093 142.024 153.430 1.00 22.24  ? 376 ARG E N   1 
ATOM   6096 C CA  . ARG C 1 305 ? 127.180 143.402 153.891 1.00 22.24  ? 376 ARG E CA  1 
ATOM   6097 C C   . ARG C 1 305 ? 125.833 144.088 153.714 1.00 22.24  ? 376 ARG E C   1 
ATOM   6098 O O   . ARG C 1 305 ? 125.241 144.040 152.629 1.00 22.24  ? 376 ARG E O   1 
ATOM   6099 C CB  . ARG C 1 305 ? 128.267 144.164 153.129 1.00 22.24  ? 376 ARG E CB  1 
ATOM   6100 C CG  . ARG C 1 305 ? 128.628 145.504 153.745 1.00 22.24  ? 376 ARG E CG  1 
ATOM   6101 C CD  . ARG C 1 305 ? 129.748 146.187 152.977 1.00 22.24  ? 376 ARG E CD  1 
ATOM   6102 N NE  . ARG C 1 305 ? 129.299 146.687 151.683 1.00 22.24  ? 376 ARG E NE  1 
ATOM   6103 C CZ  . ARG C 1 305 ? 128.844 147.914 151.473 1.00 22.24  ? 376 ARG E CZ  1 
ATOM   6104 N NH1 . ARG C 1 305 ? 128.765 148.799 152.453 1.00 22.24  ? 376 ARG E NH1 1 
ATOM   6105 N NH2 . ARG C 1 305 ? 128.459 148.263 150.249 1.00 22.24  ? 376 ARG E NH2 1 
ATOM   6106 N N   . LEU C 1 306 ? 125.357 144.728 154.780 1.00 25.02  ? 377 LEU E N   1 
ATOM   6107 C CA  . LEU C 1 306 ? 124.101 145.468 154.769 1.00 25.02  ? 377 LEU E CA  1 
ATOM   6108 C C   . LEU C 1 306 ? 124.388 146.906 155.177 1.00 25.02  ? 377 LEU E C   1 
ATOM   6109 O O   . LEU C 1 306 ? 124.802 147.160 156.312 1.00 25.02  ? 377 LEU E O   1 
ATOM   6110 C CB  . LEU C 1 306 ? 123.079 144.822 155.710 1.00 25.02  ? 377 LEU E CB  1 
ATOM   6111 C CG  . LEU C 1 306 ? 121.678 145.431 155.801 1.00 25.02  ? 377 LEU E CG  1 
ATOM   6112 C CD1 . LEU C 1 306 ? 120.637 144.331 155.912 1.00 25.02  ? 377 LEU E CD1 1 
ATOM   6113 C CD2 . LEU C 1 306 ? 121.574 146.375 156.989 1.00 25.02  ? 377 LEU E CD2 1 
ATOM   6114 N N   . GLU C 1 307 ? 124.173 147.839 154.255 1.00 33.44  ? 378 GLU E N   1 
ATOM   6115 C CA  . GLU C 1 307 ? 124.451 149.250 154.486 1.00 33.44  ? 378 GLU E CA  1 
ATOM   6116 C C   . GLU C 1 307 ? 123.141 150.026 154.500 1.00 33.44  ? 378 GLU E C   1 
ATOM   6117 O O   . GLU C 1 307 ? 122.359 149.950 153.547 1.00 33.44  ? 378 GLU E O   1 
ATOM   6118 C CB  . GLU C 1 307 ? 125.391 149.803 153.413 1.00 33.44  ? 378 GLU E CB  1 
ATOM   6119 C CG  . GLU C 1 307 ? 126.003 151.151 153.753 1.00 33.44  ? 378 GLU E CG  1 
ATOM   6120 C CD  . GLU C 1 307 ? 127.096 151.552 152.783 1.00 33.44  ? 378 GLU E CD  1 
ATOM   6121 O OE1 . GLU C 1 307 ? 127.215 150.907 151.720 1.00 33.44  ? 378 GLU E OE1 1 
ATOM   6122 O OE2 . GLU C 1 307 ? 127.839 152.510 153.083 1.00 33.44  ? 378 GLU E OE2 1 
ATOM   6123 N N   . VAL C 1 308 ? 122.908 150.768 155.580 1.00 39.08  ? 379 VAL E N   1 
ATOM   6124 C CA  . VAL C 1 308 ? 121.666 151.513 155.765 1.00 39.08  ? 379 VAL E CA  1 
ATOM   6125 C C   . VAL C 1 308 ? 121.993 152.905 156.288 1.00 39.08  ? 379 VAL E C   1 
ATOM   6126 O O   . VAL C 1 308 ? 122.920 153.079 157.085 1.00 39.08  ? 379 VAL E O   1 
ATOM   6127 C CB  . VAL C 1 308 ? 120.698 150.786 156.723 1.00 39.08  ? 379 VAL E CB  1 
ATOM   6128 C CG1 . VAL C 1 308 ? 120.061 149.592 156.029 1.00 39.08  ? 379 VAL E CG1 1 
ATOM   6129 C CG2 . VAL C 1 308 ? 121.426 150.348 157.985 1.00 39.08  ? 379 VAL E CG2 1 
ATOM   6130 N N   . ALA C 1 309 ? 121.224 153.895 155.842 1.00 47.36  ? 380 ALA E N   1 
ATOM   6131 C CA  . ALA C 1 309 ? 121.432 155.265 156.286 1.00 47.36  ? 380 ALA E CA  1 
ATOM   6132 C C   . ALA C 1 309 ? 121.191 155.384 157.789 1.00 47.36  ? 380 ALA E C   1 
ATOM   6133 O O   . ALA C 1 309 ? 120.514 154.558 158.408 1.00 47.36  ? 380 ALA E O   1 
ATOM   6134 C CB  . ALA C 1 309 ? 120.512 156.220 155.527 1.00 47.36  ? 380 ALA E CB  1 
ATOM   6135 N N   . LYS C 1 310 ? 121.756 156.438 158.379 1.00 47.94  ? 381 LYS E N   1 
ATOM   6136 C CA  . LYS C 1 310 ? 121.685 156.626 159.823 1.00 47.94  ? 381 LYS E CA  1 
ATOM   6137 C C   . LYS C 1 310 ? 120.341 157.220 160.229 1.00 47.94  ? 381 LYS E C   1 
ATOM   6138 O O   . LYS C 1 310 ? 120.286 158.255 160.902 1.00 47.94  ? 381 LYS E O   1 
ATOM   6139 C CB  . LYS C 1 310 ? 122.834 157.516 160.305 1.00 47.94  ? 381 LYS E CB  1 
ATOM   6140 C CG  . LYS C 1 310 ? 123.169 157.363 161.783 1.00 47.94  ? 381 LYS E CG  1 
ATOM   6141 C CD  . LYS C 1 310 ? 124.346 158.240 162.176 1.00 47.94  ? 381 LYS E CD  1 
ATOM   6142 C CE  . LYS C 1 310 ? 124.040 159.711 161.950 1.00 47.94  ? 381 LYS E CE  1 
ATOM   6143 N NZ  . LYS C 1 310 ? 122.878 160.167 162.761 1.00 47.94  ? 381 LYS E NZ  1 
ATOM   6144 N N   . THR C 1 311 ? 119.252 156.575 159.815 1.00 47.18  ? 382 THR E N   1 
ATOM   6145 C CA  . THR C 1 311 ? 117.913 156.968 160.235 1.00 47.18  ? 382 THR E CA  1 
ATOM   6146 C C   . THR C 1 311 ? 117.174 155.756 160.785 1.00 47.18  ? 382 THR E C   1 
ATOM   6147 O O   . THR C 1 311 ? 116.333 155.884 161.681 1.00 47.18  ? 382 THR E O   1 
ATOM   6148 C CB  . THR C 1 311 ? 117.134 157.589 159.073 1.00 47.18  ? 382 THR E CB  1 
ATOM   6149 O OG1 . THR C 1 311 ? 117.125 156.684 157.962 1.00 47.18  ? 382 THR E OG1 1 
ATOM   6150 C CG2 . THR C 1 311 ? 117.766 158.906 158.645 1.00 47.18  ? 382 THR E CG2 1 
ATOM   6151 N N   . LEU C 1 312 ? 117.485 154.575 160.253 1.00 43.94  ? 383 LEU E N   1 
ATOM   6152 C CA  . LEU C 1 312 ? 116.912 153.328 160.738 1.00 43.94  ? 383 LEU E CA  1 
ATOM   6153 C C   . LEU C 1 312 ? 117.710 152.712 161.880 1.00 43.94  ? 383 LEU E C   1 
ATOM   6154 O O   . LEU C 1 312 ? 117.201 151.808 162.551 1.00 43.94  ? 383 LEU E O   1 
ATOM   6155 C CB  . LEU C 1 312 ? 116.798 152.309 159.595 1.00 43.94  ? 383 LEU E CB  1 
ATOM   6156 C CG  . LEU C 1 312 ? 115.669 152.480 158.572 1.00 43.94  ? 383 LEU E CG  1 
ATOM   6157 C CD1 . LEU C 1 312 ? 115.954 153.613 157.595 1.00 43.94  ? 383 LEU E CD1 1 
ATOM   6158 C CD2 . LEU C 1 312 ? 115.425 151.176 157.827 1.00 43.94  ? 383 LEU E CD2 1 
ATOM   6159 N N   . TRP C 1 313 ? 118.941 153.174 162.115 1.00 38.56  ? 384 TRP E N   1 
ATOM   6160 C CA  . TRP C 1 313 ? 119.737 152.629 163.209 1.00 38.56  ? 384 TRP E CA  1 
ATOM   6161 C C   . TRP C 1 313 ? 119.133 152.969 164.565 1.00 38.56  ? 384 TRP E C   1 
ATOM   6162 O O   . TRP C 1 313 ? 119.185 152.148 165.489 1.00 38.56  ? 384 TRP E O   1 
ATOM   6163 C CB  . TRP C 1 313 ? 121.175 153.142 163.123 1.00 38.56  ? 384 TRP E CB  1 
ATOM   6164 C CG  . TRP C 1 313 ? 122.066 152.602 164.200 1.00 38.56  ? 384 TRP E CG  1 
ATOM   6165 C CD1 . TRP C 1 313 ? 122.478 153.252 165.326 1.00 38.56  ? 384 TRP E CD1 1 
ATOM   6166 C CD2 . TRP C 1 313 ? 122.648 151.294 164.255 1.00 38.56  ? 384 TRP E CD2 1 
ATOM   6167 N NE1 . TRP C 1 313 ? 123.285 152.431 166.077 1.00 38.56  ? 384 TRP E NE1 1 
ATOM   6168 C CE2 . TRP C 1 313 ? 123.404 151.223 165.442 1.00 38.56  ? 384 TRP E CE2 1 
ATOM   6169 C CE3 . TRP C 1 313 ? 122.604 150.177 163.415 1.00 38.56  ? 384 TRP E CE3 1 
ATOM   6170 C CZ2 . TRP C 1 313 ? 124.110 150.080 165.810 1.00 38.56  ? 384 TRP E CZ2 1 
ATOM   6171 C CZ3 . TRP C 1 313 ? 123.306 149.043 163.783 1.00 38.56  ? 384 TRP E CZ3 1 
ATOM   6172 C CH2 . TRP C 1 313 ? 124.048 149.003 164.970 1.00 38.56  ? 384 TRP E CH2 1 
ATOM   6173 N N   . THR C 1 314 ? 118.560 154.161 164.705 1.00 42.18  ? 385 THR E N   1 
ATOM   6174 C CA  . THR C 1 314 ? 117.891 154.564 165.934 1.00 42.18  ? 385 THR E CA  1 
ATOM   6175 C C   . THR C 1 314 ? 116.458 154.056 166.017 1.00 42.18  ? 385 THR E C   1 
ATOM   6176 O O   . THR C 1 314 ? 115.799 154.270 167.040 1.00 42.18  ? 385 THR E O   1 
ATOM   6177 C CB  . THR C 1 314 ? 117.902 156.091 166.067 1.00 42.18  ? 385 THR E CB  1 
ATOM   6178 O OG1 . THR C 1 314 ? 117.226 156.676 164.947 1.00 42.18  ? 385 THR E OG1 1 
ATOM   6179 C CG2 . THR C 1 314 ? 119.330 156.612 166.119 1.00 42.18  ? 385 THR E CG2 1 
ATOM   6180 N N   . GLN C 1 315 ? 115.965 153.396 164.974 1.00 42.40  ? 386 GLN E N   1 
ATOM   6181 C CA  . GLN C 1 315 ? 114.614 152.847 164.952 1.00 42.40  ? 386 GLN E CA  1 
ATOM   6182 C C   . GLN C 1 315 ? 114.586 151.329 164.949 1.00 42.40  ? 386 GLN E C   1 
ATOM   6183 O O   . GLN C 1 315 ? 113.868 150.731 165.755 1.00 42.40  ? 386 GLN E O   1 
ATOM   6184 C CB  . GLN C 1 315 ? 113.851 153.373 163.726 1.00 42.40  ? 386 GLN E CB  1 
ATOM   6185 C CG  . GLN C 1 315 ? 113.752 154.890 163.658 1.00 42.40  ? 386 GLN E CG  1 
ATOM   6186 C CD  . GLN C 1 315 ? 112.911 155.476 164.777 1.00 42.40  ? 386 GLN E CD  1 
ATOM   6187 O OE1 . GLN C 1 315 ? 112.068 154.794 165.360 1.00 42.40  ? 386 GLN E OE1 1 
ATOM   6188 N NE2 . GLN C 1 315 ? 113.139 156.748 165.083 1.00 42.40  ? 386 GLN E NE2 1 
ATOM   6189 N N   . ARG C 1 316 ? 115.346 150.686 164.066 1.00 45.37  ? 387 ARG E N   1 
ATOM   6190 C CA  . ARG C 1 316 ? 115.414 149.232 164.042 1.00 45.37  ? 387 ARG E CA  1 
ATOM   6191 C C   . ARG C 1 316 ? 116.152 148.720 165.271 1.00 45.37  ? 387 ARG E C   1 
ATOM   6192 O O   . ARG C 1 316 ? 117.123 149.329 165.730 1.00 45.37  ? 387 ARG E O   1 
ATOM   6193 C CB  . ARG C 1 316 ? 116.106 148.746 162.769 1.00 45.37  ? 387 ARG E CB  1 
ATOM   6194 C CG  . ARG C 1 316 ? 115.383 149.129 161.488 1.00 45.37  ? 387 ARG E CG  1 
ATOM   6195 C CD  . ARG C 1 316 ? 113.932 148.678 161.523 1.00 45.37  ? 387 ARG E CD  1 
ATOM   6196 N NE  . ARG C 1 316 ? 113.230 148.985 160.283 1.00 45.37  ? 387 ARG E NE  1 
ATOM   6197 C CZ  . ARG C 1 316 ? 113.102 148.143 159.267 1.00 45.37  ? 387 ARG E CZ  1 
ATOM   6198 N NH1 . ARG C 1 316 ? 113.617 146.925 159.309 1.00 45.37  ? 387 ARG E NH1 1 
ATOM   6199 N NH2 . ARG C 1 316 ? 112.438 148.532 158.182 1.00 45.37  ? 387 ARG E NH2 1 
ATOM   6200 N N   . LYS C 1 317 ? 115.684 147.593 165.805 1.00 44.68  ? 388 LYS E N   1 
ATOM   6201 C CA  . LYS C 1 317 ? 116.234 147.068 167.048 1.00 44.68  ? 388 LYS E CA  1 
ATOM   6202 C C   . LYS C 1 317 ? 116.637 145.604 166.918 1.00 44.68  ? 388 LYS E C   1 
ATOM   6203 O O   . LYS C 1 317 ? 117.555 145.147 167.607 1.00 44.68  ? 388 LYS E O   1 
ATOM   6204 C CB  . LYS C 1 317 ? 115.222 147.239 168.185 1.00 44.68  ? 388 LYS E CB  1 
ATOM   6205 C CG  . LYS C 1 317 ? 115.787 146.980 169.572 1.00 44.68  ? 388 LYS E CG  1 
ATOM   6206 C CD  . LYS C 1 317 ? 116.887 147.973 169.912 1.00 44.68  ? 388 LYS E CD  1 
ATOM   6207 C CE  . LYS C 1 317 ? 117.425 147.744 171.315 1.00 44.68  ? 388 LYS E CE  1 
ATOM   6208 N NZ  . LYS C 1 317 ? 118.005 146.383 171.474 1.00 44.68  ? 388 LYS E NZ  1 
ATOM   6209 N N   . GLN C 1 318 ? 115.964 144.859 166.038 1.00 44.65  ? 389 GLN E N   1 
ATOM   6210 C CA  . GLN C 1 318 ? 116.209 143.422 165.956 1.00 44.65  ? 389 GLN E CA  1 
ATOM   6211 C C   . GLN C 1 318 ? 117.555 143.128 165.302 1.00 44.65  ? 389 GLN E C   1 
ATOM   6212 O O   . GLN C 1 318 ? 118.472 142.615 165.953 1.00 44.65  ? 389 GLN E O   1 
ATOM   6213 C CB  . GLN C 1 318 ? 115.072 142.742 165.191 1.00 44.65  ? 389 GLN E CB  1 
ATOM   6214 C CG  . GLN C 1 318 ? 115.194 141.230 165.103 1.00 44.65  ? 389 GLN E CG  1 
ATOM   6215 C CD  . GLN C 1 318 ? 115.080 140.552 166.456 1.00 44.65  ? 389 GLN E CD  1 
ATOM   6216 O OE1 . GLN C 1 318 ? 114.478 141.090 167.386 1.00 44.65  ? 389 GLN E OE1 1 
ATOM   6217 N NE2 . GLN C 1 318 ? 115.661 139.364 166.572 1.00 44.65  ? 389 GLN E NE2 1 
ATOM   6218 N N   . PHE C 1 319 ? 117.701 143.478 164.024 1.00 36.80  ? 390 PHE E N   1 
ATOM   6219 C CA  . PHE C 1 319 ? 118.945 143.294 163.273 1.00 36.80  ? 390 PHE E CA  1 
ATOM   6220 C C   . PHE C 1 319 ? 119.490 141.871 163.438 1.00 36.80  ? 390 PHE E C   1 
ATOM   6221 O O   . PHE C 1 319 ? 120.525 141.626 164.060 1.00 36.80  ? 390 PHE E O   1 
ATOM   6222 C CB  . PHE C 1 319 ? 119.983 144.343 163.685 1.00 36.80  ? 390 PHE E CB  1 
ATOM   6223 C CG  . PHE C 1 319 ? 119.802 145.669 163.004 1.00 36.80  ? 390 PHE E CG  1 
ATOM   6224 C CD1 . PHE C 1 319 ? 119.325 145.733 161.705 1.00 36.80  ? 390 PHE E CD1 1 
ATOM   6225 C CD2 . PHE C 1 319 ? 120.104 146.849 163.660 1.00 36.80  ? 390 PHE E CD2 1 
ATOM   6226 C CE1 . PHE C 1 319 ? 119.156 146.950 161.072 1.00 36.80  ? 390 PHE E CE1 1 
ATOM   6227 C CE2 . PHE C 1 319 ? 119.935 148.069 163.033 1.00 36.80  ? 390 PHE E CE2 1 
ATOM   6228 C CZ  . PHE C 1 319 ? 119.462 148.119 161.737 1.00 36.80  ? 390 PHE E CZ  1 
ATOM   6229 N N   . THR C 1 320 ? 118.732 140.927 162.887 1.00 32.45  ? 391 THR E N   1 
ATOM   6230 C CA  . THR C 1 320 ? 119.075 139.512 162.948 1.00 32.45  ? 391 THR E CA  1 
ATOM   6231 C C   . THR C 1 320 ? 119.452 139.017 161.557 1.00 32.45  ? 391 THR E C   1 
ATOM   6232 O O   . THR C 1 320 ? 118.667 139.144 160.608 1.00 32.45  ? 391 THR E O   1 
ATOM   6233 C CB  . THR C 1 320 ? 117.920 138.690 163.517 1.00 32.45  ? 391 THR E CB  1 
ATOM   6234 O OG1 . THR C 1 320 ? 117.613 139.148 164.839 1.00 32.45  ? 391 THR E OG1 1 
ATOM   6235 C CG2 . THR C 1 320 ? 118.299 137.221 163.579 1.00 32.45  ? 391 THR E CG2 1 
ATOM   6236 N N   . CYS C 1 321 ? 120.655 138.457 161.445 1.00 27.15  ? 392 CYS E N   1 
ATOM   6237 C CA  . CYS C 1 321 ? 121.127 137.811 160.227 1.00 27.15  ? 392 CYS E CA  1 
ATOM   6238 C C   . CYS C 1 321 ? 120.765 136.332 160.291 1.00 27.15  ? 392 CYS E C   1 
ATOM   6239 O O   . CYS C 1 321 ? 121.145 135.635 161.240 1.00 27.15  ? 392 CYS E O   1 
ATOM   6240 C CB  . CYS C 1 321 ? 122.637 137.997 160.072 1.00 27.15  ? 392 CYS E CB  1 
ATOM   6241 S SG  . CYS C 1 321 ? 123.404 137.081 158.706 1.00 27.15  ? 392 CYS E SG  1 
ATOM   6242 N N   . GLN C 1 322 ? 120.028 135.858 159.290 1.00 23.15  ? 393 GLN E N   1 
ATOM   6243 C CA  . GLN C 1 322 ? 119.567 134.481 159.220 1.00 23.15  ? 393 GLN E CA  1 
ATOM   6244 C C   . GLN C 1 322 ? 120.292 133.754 158.097 1.00 23.15  ? 393 GLN E C   1 
ATOM   6245 O O   . GLN C 1 322 ? 120.487 134.307 157.010 1.00 23.15  ? 393 GLN E O   1 
ATOM   6246 C CB  . GLN C 1 322 ? 118.055 134.419 158.987 1.00 23.15  ? 393 GLN E CB  1 
ATOM   6247 C CG  . GLN C 1 322 ? 117.507 133.020 158.760 1.00 23.15  ? 393 GLN E CG  1 
ATOM   6248 C CD  . GLN C 1 322 ? 116.042 133.026 158.373 1.00 23.15  ? 393 GLN E CD  1 
ATOM   6249 O OE1 . GLN C 1 322 ? 115.351 134.033 158.529 1.00 23.15  ? 393 GLN E OE1 1 
ATOM   6250 N NE2 . GLN C 1 322 ? 115.561 131.901 157.859 1.00 23.15  ? 393 GLN E NE2 1 
ATOM   6251 N N   . VAL C 1 323 ? 120.701 132.519 158.368 1.00 18.30  ? 394 VAL E N   1 
ATOM   6252 C CA  . VAL C 1 323 ? 121.379 131.680 157.391 1.00 18.30  ? 394 VAL E CA  1 
ATOM   6253 C C   . VAL C 1 323 ? 120.640 130.355 157.304 1.00 18.30  ? 394 VAL E C   1 
ATOM   6254 O O   . VAL C 1 323 ? 120.361 129.723 158.330 1.00 18.30  ? 394 VAL E O   1 
ATOM   6255 C CB  . VAL C 1 323 ? 122.859 131.461 157.758 1.00 18.30  ? 394 VAL E CB  1 
ATOM   6256 C CG1 . VAL C 1 323 ? 123.504 130.477 156.799 1.00 18.30  ? 394 VAL E CG1 1 
ATOM   6257 C CG2 . VAL C 1 323 ? 123.596 132.788 157.739 1.00 18.30  ? 394 VAL E CG2 1 
ATOM   6258 N N   . ILE C 1 324 ? 120.315 129.943 156.082 1.00 17.17  ? 395 ILE E N   1 
ATOM   6259 C CA  . ILE C 1 324 ? 119.627 128.686 155.818 1.00 17.17  ? 395 ILE E CA  1 
ATOM   6260 C C   . ILE C 1 324 ? 120.595 127.768 155.088 1.00 17.17  ? 395 ILE E C   1 
ATOM   6261 O O   . ILE C 1 324 ? 121.118 128.120 154.021 1.00 17.17  ? 395 ILE E O   1 
ATOM   6262 C CB  . ILE C 1 324 ? 118.343 128.899 155.003 1.00 17.17  ? 395 ILE E CB  1 
ATOM   6263 C CG1 . ILE C 1 324 ? 117.380 129.821 155.754 1.00 17.17  ? 395 ILE E CG1 1 
ATOM   6264 C CG2 . ILE C 1 324 ? 117.679 127.564 154.698 1.00 17.17  ? 395 ILE E CG2 1 
ATOM   6265 C CD1 . ILE C 1 324 ? 116.095 130.100 155.006 1.00 17.17  ? 395 ILE E CD1 1 
ATOM   6266 N N   . HIS C 1 325 ? 120.835 126.595 155.671 1.00 18.59  ? 396 HIS E N   1 
ATOM   6267 C CA  . HIS C 1 325 ? 121.702 125.578 155.099 1.00 18.59  ? 396 HIS E CA  1 
ATOM   6268 C C   . HIS C 1 325 ? 121.049 124.221 155.318 1.00 18.59  ? 396 HIS E C   1 
ATOM   6269 O O   . HIS C 1 325 ? 120.231 124.045 156.224 1.00 18.59  ? 396 HIS E O   1 
ATOM   6270 C CB  . HIS C 1 325 ? 123.104 125.617 155.725 1.00 18.59  ? 396 HIS E CB  1 
ATOM   6271 C CG  . HIS C 1 325 ? 124.125 124.816 154.978 1.00 18.59  ? 396 HIS E CG  1 
ATOM   6272 N ND1 . HIS C 1 325 ? 124.323 123.470 155.199 1.00 18.59  ? 396 HIS E ND1 1 
ATOM   6273 C CD2 . HIS C 1 325 ? 125.010 125.174 154.018 1.00 18.59  ? 396 HIS E CD2 1 
ATOM   6274 C CE1 . HIS C 1 325 ? 125.283 123.032 154.403 1.00 18.59  ? 396 HIS E CE1 1 
ATOM   6275 N NE2 . HIS C 1 325 ? 125.717 124.046 153.677 1.00 18.59  ? 396 HIS E NE2 1 
ATOM   6276 N N   . GLU C 1 326 ? 121.421 123.255 154.482 1.00 21.68  ? 397 GLU E N   1 
ATOM   6277 C CA  . GLU C 1 326 ? 120.788 121.943 154.520 1.00 21.68  ? 397 GLU E CA  1 
ATOM   6278 C C   . GLU C 1 326 ? 121.374 121.022 155.583 1.00 21.68  ? 397 GLU E C   1 
ATOM   6279 O O   . GLU C 1 326 ? 120.927 119.875 155.694 1.00 21.68  ? 397 GLU E O   1 
ATOM   6280 C CB  . GLU C 1 326 ? 120.884 121.270 153.147 1.00 21.68  ? 397 GLU E CB  1 
ATOM   6281 C CG  . GLU C 1 326 ? 122.296 120.921 152.713 1.00 21.68  ? 397 GLU E CG  1 
ATOM   6282 C CD  . GLU C 1 326 ? 122.328 120.196 151.381 1.00 21.68  ? 397 GLU E CD  1 
ATOM   6283 O OE1 . GLU C 1 326 ? 121.273 120.125 150.717 1.00 21.68  ? 397 GLU E OE1 1 
ATOM   6284 O OE2 . GLU C 1 326 ? 123.406 119.694 151.000 1.00 21.68  ? 397 GLU E OE2 1 
ATOM   6285 N N   . ALA C 1 327 ? 122.354 121.484 156.363 1.00 20.21  ? 398 ALA E N   1 
ATOM   6286 C CA  . ALA C 1 327 ? 122.977 120.653 157.386 1.00 20.21  ? 398 ALA E CA  1 
ATOM   6287 C C   . ALA C 1 327 ? 123.045 121.335 158.748 1.00 20.21  ? 398 ALA E C   1 
ATOM   6288 O O   . ALA C 1 327 ? 123.705 120.810 159.653 1.00 20.21  ? 398 ALA E O   1 
ATOM   6289 C CB  . ALA C 1 327 ? 124.385 120.232 156.951 1.00 20.21  ? 398 ALA E CB  1 
ATOM   6290 N N   . LEU C 1 328 ? 122.395 122.486 158.918 1.00 20.15  ? 399 LEU E N   1 
ATOM   6291 C CA  . LEU C 1 328 ? 122.423 123.198 160.191 1.00 20.15  ? 399 LEU E CA  1 
ATOM   6292 C C   . LEU C 1 328 ? 121.784 122.387 161.311 1.00 20.15  ? 399 LEU E C   1 
ATOM   6293 O O   . LEU C 1 328 ? 122.464 121.983 162.259 1.00 20.15  ? 399 LEU E O   1 
ATOM   6294 C CB  . LEU C 1 328 ? 121.718 124.549 160.058 1.00 20.15  ? 399 LEU E CB  1 
ATOM   6295 C CG  . LEU C 1 328 ? 122.584 125.731 159.623 1.00 20.15  ? 399 LEU E CG  1 
ATOM   6296 C CD1 . LEU C 1 328 ? 121.713 126.911 159.232 1.00 20.15  ? 399 LEU E CD1 1 
ATOM   6297 C CD2 . LEU C 1 328 ? 123.534 126.117 160.744 1.00 20.15  ? 399 LEU E CD2 1 
ATOM   6298 N N   . GLN C 1 329 ? 120.486 122.137 161.202 1.00 23.52  ? 400 GLN E N   1 
ATOM   6299 C CA  . GLN C 1 329 ? 119.716 121.420 162.217 1.00 23.52  ? 400 GLN E CA  1 
ATOM   6300 C C   . GLN C 1 329 ? 118.367 121.073 161.594 1.00 23.52  ? 400 GLN E C   1 
ATOM   6301 O O   . GLN C 1 329 ? 118.165 121.244 160.386 1.00 23.52  ? 400 GLN E O   1 
ATOM   6302 C CB  . GLN C 1 329 ? 119.578 122.252 163.496 1.00 23.52  ? 400 GLN E CB  1 
ATOM   6303 C CG  . GLN C 1 329 ? 119.351 121.442 164.768 1.00 23.52  ? 400 GLN E CG  1 
ATOM   6304 C CD  . GLN C 1 329 ? 120.544 120.580 165.140 1.00 23.52  ? 400 GLN E CD  1 
ATOM   6305 O OE1 . GLN C 1 329 ? 121.678 120.871 164.760 1.00 23.52  ? 400 GLN E OE1 1 
ATOM   6306 N NE2 . GLN C 1 329 ? 120.291 119.512 165.887 1.00 23.52  ? 400 GLN E NE2 1 
ATOM   6307 N N   . LYS C 1 330 ? 117.442 120.575 162.416 1.00 27.02  ? 401 LYS E N   1 
ATOM   6308 C CA  . LYS C 1 330 ? 116.094 120.285 161.930 1.00 27.02  ? 401 LYS E CA  1 
ATOM   6309 C C   . LYS C 1 330 ? 115.388 121.515 161.369 1.00 27.02  ? 401 LYS E C   1 
ATOM   6310 O O   . LYS C 1 330 ? 114.765 121.402 160.298 1.00 27.02  ? 401 LYS E O   1 
ATOM   6311 C CB  . LYS C 1 330 ? 115.274 119.626 163.045 1.00 27.02  ? 401 LYS E CB  1 
ATOM   6312 C CG  . LYS C 1 330 ? 115.741 118.228 163.415 1.00 27.02  ? 401 LYS E CG  1 
ATOM   6313 C CD  . LYS C 1 330 ? 115.601 117.271 162.240 1.00 27.02  ? 401 LYS E CD  1 
ATOM   6314 C CE  . LYS C 1 330 ? 114.151 117.145 161.800 1.00 27.02  ? 401 LYS E CE  1 
ATOM   6315 N NZ  . LYS C 1 330 ? 114.001 116.230 160.634 1.00 27.02  ? 401 LYS E NZ  1 
ATOM   6316 N N   . PRO C 1 331 ? 115.412 122.689 162.014 1.00 24.34  ? 402 PRO E N   1 
ATOM   6317 C CA  . PRO C 1 331 ? 114.823 123.874 161.367 1.00 24.34  ? 402 PRO E CA  1 
ATOM   6318 C C   . PRO C 1 331 ? 115.616 124.378 160.173 1.00 24.34  ? 402 PRO E C   1 
ATOM   6319 O O   . PRO C 1 331 ? 115.071 125.155 159.380 1.00 24.34  ? 402 PRO E O   1 
ATOM   6320 C CB  . PRO C 1 331 ? 114.792 124.914 162.495 1.00 24.34  ? 402 PRO E CB  1 
ATOM   6321 C CG  . PRO C 1 331 ? 115.880 124.497 163.411 1.00 24.34  ? 402 PRO E CG  1 
ATOM   6322 C CD  . PRO C 1 331 ? 115.866 122.998 163.383 1.00 24.34  ? 402 PRO E CD  1 
ATOM   6323 N N   . ARG C 1 332 ? 116.877 123.961 160.023 1.00 24.50  ? 403 ARG E N   1 
ATOM   6324 C CA  . ARG C 1 332 ? 117.754 124.437 158.949 1.00 24.50  ? 403 ARG E CA  1 
ATOM   6325 C C   . ARG C 1 332 ? 117.868 125.961 158.954 1.00 24.50  ? 403 ARG E C   1 
ATOM   6326 O O   . ARG C 1 332 ? 117.906 126.603 157.902 1.00 24.50  ? 403 ARG E O   1 
ATOM   6327 C CB  . ARG C 1 332 ? 117.288 123.937 157.578 1.00 24.50  ? 403 ARG E CB  1 
ATOM   6328 C CG  . ARG C 1 332 ? 117.613 122.481 157.276 1.00 24.50  ? 403 ARG E CG  1 
ATOM   6329 C CD  . ARG C 1 332 ? 116.476 121.556 157.668 1.00 24.50  ? 403 ARG E CD  1 
ATOM   6330 N NE  . ARG C 1 332 ? 116.654 120.212 157.130 1.00 24.50  ? 403 ARG E NE  1 
ATOM   6331 C CZ  . ARG C 1 332 ? 117.290 119.231 157.755 1.00 24.50  ? 403 ARG E CZ  1 
ATOM   6332 N NH1 . ARG C 1 332 ? 117.826 119.406 158.951 1.00 24.50  ? 403 ARG E NH1 1 
ATOM   6333 N NH2 . ARG C 1 332 ? 117.390 118.043 157.164 1.00 24.50  ? 403 ARG E NH2 1 
ATOM   6334 N N   . LYS C 1 333 ? 117.922 126.546 160.149 1.00 22.45  ? 404 LYS E N   1 
ATOM   6335 C CA  . LYS C 1 333 ? 118.009 127.991 160.304 1.00 22.45  ? 404 LYS E CA  1 
ATOM   6336 C C   . LYS C 1 333 ? 118.983 128.326 161.422 1.00 22.45  ? 404 LYS E C   1 
ATOM   6337 O O   . LYS C 1 333 ? 118.956 127.701 162.486 1.00 22.45  ? 404 LYS E O   1 
ATOM   6338 C CB  . LYS C 1 333 ? 116.636 128.606 160.611 1.00 22.45  ? 404 LYS E CB  1 
ATOM   6339 C CG  . LYS C 1 333 ? 115.624 128.488 159.483 1.00 22.45  ? 404 LYS E CG  1 
ATOM   6340 C CD  . LYS C 1 333 ? 114.240 128.928 159.935 1.00 22.45  ? 404 LYS E CD  1 
ATOM   6341 C CE  . LYS C 1 333 ? 114.260 130.343 160.490 1.00 22.45  ? 404 LYS E CE  1 
ATOM   6342 N NZ  . LYS C 1 333 ? 112.910 130.785 160.934 1.00 22.45  ? 404 LYS E NZ  1 
ATOM   6343 N N   . LEU C 1 334 ? 119.842 129.315 161.178 1.00 20.66  ? 405 LEU E N   1 
ATOM   6344 C CA  . LEU C 1 334 ? 120.749 129.833 162.196 1.00 20.66  ? 405 LEU E CA  1 
ATOM   6345 C C   . LEU C 1 334 ? 120.649 131.350 162.198 1.00 20.66  ? 405 LEU E C   1 
ATOM   6346 O O   . LEU C 1 334 ? 120.961 131.994 161.192 1.00 20.66  ? 405 LEU E O   1 
ATOM   6347 C CB  . LEU C 1 334 ? 122.190 129.382 161.942 1.00 20.66  ? 405 LEU E CB  1 
ATOM   6348 C CG  . LEU C 1 334 ? 123.202 129.732 163.034 1.00 20.66  ? 405 LEU E CG  1 
ATOM   6349 C CD1 . LEU C 1 334 ? 122.720 129.233 164.387 1.00 20.66  ? 405 LEU E CD1 1 
ATOM   6350 C CD2 . LEU C 1 334 ? 124.568 129.151 162.707 1.00 20.66  ? 405 LEU E CD2 1 
ATOM   6351 N N   . GLU C 1 335 ? 120.215 131.916 163.320 1.00 25.55  ? 406 GLU E N   1 
ATOM   6352 C CA  . GLU C 1 335 ? 119.968 133.347 163.436 1.00 25.55  ? 406 GLU E CA  1 
ATOM   6353 C C   . GLU C 1 335 ? 120.922 133.955 164.453 1.00 25.55  ? 406 GLU E C   1 
ATOM   6354 O O   . GLU C 1 335 ? 121.062 133.437 165.566 1.00 25.55  ? 406 GLU E O   1 
ATOM   6355 C CB  . GLU C 1 335 ? 118.517 133.619 163.843 1.00 25.55  ? 406 GLU E CB  1 
ATOM   6356 C CG  . GLU C 1 335 ? 117.488 133.107 162.849 1.00 25.55  ? 406 GLU E CG  1 
ATOM   6357 C CD  . GLU C 1 335 ? 116.064 133.394 163.285 1.00 25.55  ? 406 GLU E CD  1 
ATOM   6358 O OE1 . GLU C 1 335 ? 115.880 133.956 164.385 1.00 25.55  ? 406 GLU E OE1 1 
ATOM   6359 O OE2 . GLU C 1 335 ? 115.130 133.058 162.528 1.00 25.55  ? 406 GLU E OE2 1 
ATOM   6360 N N   . LYS C 1 336 ? 121.574 135.050 164.067 1.00 25.16  ? 407 LYS E N   1 
ATOM   6361 C CA  . LYS C 1 336 ? 122.454 135.802 164.954 1.00 25.16  ? 407 LYS E CA  1 
ATOM   6362 C C   . LYS C 1 336 ? 121.940 137.232 165.042 1.00 25.16  ? 407 LYS E C   1 
ATOM   6363 O O   . LYS C 1 336 ? 121.812 137.911 164.019 1.00 25.16  ? 407 LYS E O   1 
ATOM   6364 C CB  . LYS C 1 336 ? 123.900 135.772 164.454 1.00 25.16  ? 407 LYS E CB  1 
ATOM   6365 C CG  . LYS C 1 336 ? 124.489 134.376 164.344 1.00 25.16  ? 407 LYS E CG  1 
ATOM   6366 C CD  . LYS C 1 336 ? 124.490 133.669 165.690 1.00 25.16  ? 407 LYS E CD  1 
ATOM   6367 C CE  . LYS C 1 336 ? 125.068 132.267 165.577 1.00 25.16  ? 407 LYS E CE  1 
ATOM   6368 N NZ  . LYS C 1 336 ? 125.074 131.562 166.888 1.00 25.16  ? 407 LYS E NZ  1 
ATOM   6369 N N   . THR C 1 337 ? 121.661 137.689 166.258 1.00 34.32  ? 408 THR E N   1 
ATOM   6370 C CA  . THR C 1 337 ? 121.014 138.973 166.495 1.00 34.32  ? 408 THR E CA  1 
ATOM   6371 C C   . THR C 1 337 ? 122.014 139.961 167.080 1.00 34.32  ? 408 THR E C   1 
ATOM   6372 O O   . THR C 1 337 ? 122.730 139.633 168.032 1.00 34.32  ? 408 THR E O   1 
ATOM   6373 C CB  . THR C 1 337 ? 119.820 138.808 167.440 1.00 34.32  ? 408 THR E CB  1 
ATOM   6374 O OG1 . THR C 1 337 ? 118.805 138.022 166.801 1.00 34.32  ? 408 THR E OG1 1 
ATOM   6375 C CG2 . THR C 1 337 ? 119.242 140.160 167.827 1.00 34.32  ? 408 THR E CG2 1 
ATOM   6376 N N   . ILE C 1 338 ? 122.062 141.167 166.513 1.00 37.16  ? 409 ILE E N   1 
ATOM   6377 C CA  . ILE C 1 338 ? 122.884 142.251 167.033 1.00 37.16  ? 409 ILE E CA  1 
ATOM   6378 C C   . ILE C 1 338 ? 121.966 143.402 167.424 1.00 37.16  ? 409 ILE E C   1 
ATOM   6379 O O   . ILE C 1 338 ? 121.026 143.735 166.694 1.00 37.16  ? 409 ILE E O   1 
ATOM   6380 C CB  . ILE C 1 338 ? 123.952 142.708 166.015 1.00 37.16  ? 409 ILE E CB  1 
ATOM   6381 C CG1 . ILE C 1 338 ? 124.781 143.864 166.580 1.00 37.16  ? 409 ILE E CG1 1 
ATOM   6382 C CG2 . ILE C 1 338 ? 123.317 143.093 164.686 1.00 37.16  ? 409 ILE E CG2 1 
ATOM   6383 C CD1 . ILE C 1 338 ? 125.548 143.509 167.836 1.00 37.16  ? 409 ILE E CD1 1 
ATOM   6384 N N   . SER C 1 339 ? 122.225 143.992 168.587 1.00 44.47  ? 410 SER E N   1 
ATOM   6385 C CA  . SER C 1 339 ? 121.387 145.046 169.140 1.00 44.47  ? 410 SER E CA  1 
ATOM   6386 C C   . SER C 1 339 ? 122.098 146.389 169.048 1.00 44.47  ? 410 SER E C   1 
ATOM   6387 O O   . SER C 1 339 ? 123.318 146.472 169.227 1.00 44.47  ? 410 SER E O   1 
ATOM   6388 C CB  . SER C 1 339 ? 121.023 144.748 170.598 1.00 44.47  ? 410 SER E CB  1 
ATOM   6389 O OG  . SER C 1 339 ? 122.185 144.643 171.402 1.00 44.47  ? 410 SER E OG  1 
ATOM   6390 N N   . THR C 1 340 ? 121.327 147.439 168.765 1.00 42.53  ? 411 THR E N   1 
ATOM   6391 C CA  . THR C 1 340 ? 121.871 148.786 168.651 1.00 42.53  ? 411 THR E CA  1 
ATOM   6392 C C   . THR C 1 340 ? 122.089 149.457 170.000 1.00 42.53  ? 411 THR E C   1 
ATOM   6393 O O   . THR C 1 340 ? 122.758 150.494 170.055 1.00 42.53  ? 411 THR E O   1 
ATOM   6394 C CB  . THR C 1 340 ? 120.947 149.659 167.797 1.00 42.53  ? 411 THR E CB  1 
ATOM   6395 O OG1 . THR C 1 340 ? 119.684 149.808 168.457 1.00 42.53  ? 411 THR E OG1 1 
ATOM   6396 C CG2 . THR C 1 340 ? 120.726 149.024 166.435 1.00 42.53  ? 411 THR E CG2 1 
ATOM   6397 N N   . SER C 1 341 ? 121.545 148.899 171.080 1.00 49.18  ? 412 SER E N   1 
ATOM   6398 C CA  . SER C 1 341 ? 121.682 149.490 172.412 1.00 49.18  ? 412 SER E CA  1 
ATOM   6399 C C   . SER C 1 341 ? 122.926 148.942 173.116 1.00 49.18  ? 412 SER E C   1 
ATOM   6400 O O   . SER C 1 341 ? 122.870 148.366 174.201 1.00 49.18  ? 412 SER E O   1 
ATOM   6401 C CB  . SER C 1 341 ? 120.422 149.238 173.232 1.00 49.18  ? 412 SER E CB  1 
ATOM   6402 O OG  . SER C 1 341 ? 120.532 149.808 174.525 1.00 49.18  ? 412 SER E OG  1 
ATOM   6403 N N   . LEU C 1 342 ? 124.072 149.139 172.464 1.00 48.56  ? 413 LEU E N   1 
ATOM   6404 C CA  . LEU C 1 342 ? 125.346 148.686 173.006 1.00 48.56  ? 413 LEU E CA  1 
ATOM   6405 C C   . LEU C 1 342 ? 126.348 149.832 173.056 1.00 48.56  ? 413 LEU E C   1 
ATOM   6406 O O   . LEU C 1 342 ? 125.998 150.984 172.782 1.00 48.56  ? 413 LEU E O   1 
ATOM   6407 C CB  . LEU C 1 342 ? 125.903 147.528 172.175 1.00 48.56  ? 413 LEU E CB  1 
ATOM   6408 C CG  . LEU C 1 342 ? 125.055 146.255 172.122 1.00 48.56  ? 413 LEU E CG  1 
ATOM   6409 C CD1 . LEU C 1 342 ? 125.722 145.201 171.252 1.00 48.56  ? 413 LEU E CD1 1 
ATOM   6410 C CD2 . LEU C 1 342 ? 124.804 145.718 173.523 1.00 48.56  ? 413 LEU E CD2 1 
ATOM   6411 N N   . GLY C 1 343 ? 127.594 149.526 173.405 1.00 49.13  ? 414 GLY E N   1 
ATOM   6412 C CA  . GLY C 1 343 ? 128.633 150.536 173.486 1.00 49.13  ? 414 GLY E CA  1 
ATOM   6413 C C   . GLY C 1 343 ? 128.541 151.390 174.736 1.00 49.13  ? 414 GLY E C   1 
ATOM   6414 O O   . GLY C 1 343 ? 127.710 152.293 174.822 1.00 49.13  ? 414 GLY E O   1 
HETATM 6415 C C1  . NAG D 3 .   ? 146.697 125.006 127.631 1.00 42.25  ? 1   NAG x C1  1 
HETATM 6416 C C2  . NAG D 3 .   ? 145.388 125.777 127.417 1.00 42.25  ? 1   NAG x C2  1 
HETATM 6417 C C3  . NAG D 3 .   ? 145.622 127.266 127.667 1.00 42.25  ? 1   NAG x C3  1 
HETATM 6418 C C4  . NAG D 3 .   ? 146.274 127.495 129.027 1.00 42.25  ? 1   NAG x C4  1 
HETATM 6419 C C5  . NAG D 3 .   ? 147.518 126.607 129.154 1.00 42.25  ? 1   NAG x C5  1 
HETATM 6420 C C6  . NAG D 3 .   ? 148.220 126.712 130.491 1.00 42.25  ? 1   NAG x C6  1 
HETATM 6421 C C7  . NAG D 3 .   ? 143.707 124.942 125.818 1.00 42.25  ? 1   NAG x C7  1 
HETATM 6422 C C8  . NAG D 3 .   ? 143.374 124.827 124.351 1.00 42.25  ? 1   NAG x C8  1 
HETATM 6423 N N2  . NAG D 3 .   ? 144.873 125.558 126.091 1.00 42.25  ? 1   NAG x N2  1 
HETATM 6424 O O3  . NAG D 3 .   ? 144.386 127.922 127.560 1.00 42.25  ? 1   NAG x O3  1 
HETATM 6425 O O4  . NAG D 3 .   ? 146.605 128.864 129.097 1.00 42.25  ? 1   NAG x O4  1 
HETATM 6426 O O5  . NAG D 3 .   ? 147.160 125.257 128.937 1.00 42.25  ? 1   NAG x O5  1 
HETATM 6427 O O6  . NAG D 3 .   ? 147.316 126.412 131.528 1.00 42.25  ? 1   NAG x O6  1 
HETATM 6428 O O7  . NAG D 3 .   ? 142.960 124.502 126.679 1.00 42.25  ? 1   NAG x O7  1 
HETATM 6429 C C1  . NAG D 3 .   ? 145.868 129.485 130.170 1.00 36.08  ? 2   NAG x C1  1 
HETATM 6430 C C2  . NAG D 3 .   ? 146.706 130.655 130.708 1.00 36.08  ? 2   NAG x C2  1 
HETATM 6431 C C3  . NAG D 3 .   ? 145.928 131.413 131.783 1.00 36.08  ? 2   NAG x C3  1 
HETATM 6432 C C4  . NAG D 3 .   ? 144.539 131.795 131.283 1.00 36.08  ? 2   NAG x C4  1 
HETATM 6433 C C5  . NAG D 3 .   ? 143.836 130.541 130.749 1.00 36.08  ? 2   NAG x C5  1 
HETATM 6434 C C6  . NAG D 3 .   ? 142.445 130.787 130.208 1.00 36.08  ? 2   NAG x C6  1 
HETATM 6435 C C7  . NAG D 3 .   ? 149.165 130.449 130.694 1.00 36.08  ? 2   NAG x C7  1 
HETATM 6436 C C8  . NAG D 3 .   ? 150.338 129.840 131.422 1.00 36.08  ? 2   NAG x C8  1 
HETATM 6437 N N2  . NAG D 3 .   ? 147.960 130.182 131.231 1.00 36.08  ? 2   NAG x N2  1 
HETATM 6438 O O3  . NAG D 3 .   ? 146.682 132.538 132.149 1.00 36.08  ? 2   NAG x O3  1 
HETATM 6439 O O4  . NAG D 3 .   ? 143.851 132.363 132.375 1.00 36.08  ? 2   NAG x O4  1 
HETATM 6440 O O5  . NAG D 3 .   ? 144.625 129.974 129.721 1.00 36.08  ? 2   NAG x O5  1 
HETATM 6441 O O6  . NAG D 3 .   ? 142.496 131.742 129.175 1.00 36.08  ? 2   NAG x O6  1 
HETATM 6442 O O7  . NAG D 3 .   ? 149.320 131.132 129.693 1.00 36.08  ? 2   NAG x O7  1 
HETATM 6443 C C1  . BMA D 3 .   ? 143.513 133.733 132.067 1.00 34.41  ? 3   BMA x C1  1 
HETATM 6444 C C2  . BMA D 3 .   ? 142.117 134.000 132.615 1.00 34.41  ? 3   BMA x C2  1 
HETATM 6445 C C3  . BMA D 3 .   ? 141.682 135.436 132.242 1.00 34.41  ? 3   BMA x C3  1 
HETATM 6446 C C4  . BMA D 3 .   ? 142.843 136.438 132.060 1.00 34.41  ? 3   BMA x C4  1 
HETATM 6447 C C5  . BMA D 3 .   ? 144.159 136.019 132.721 1.00 34.41  ? 3   BMA x C5  1 
HETATM 6448 C C6  . BMA D 3 .   ? 144.265 136.503 134.164 1.00 34.41  ? 3   BMA x C6  1 
HETATM 6449 O O2  . BMA D 3 .   ? 142.132 133.774 133.999 1.00 34.41  ? 3   BMA x O2  1 
HETATM 6450 O O3  . BMA D 3 .   ? 140.749 135.841 133.214 1.00 34.41  ? 3   BMA x O3  1 
HETATM 6451 O O4  . BMA D 3 .   ? 143.002 136.585 130.663 1.00 34.41  ? 3   BMA x O4  1 
HETATM 6452 O O5  . BMA D 3 .   ? 144.441 134.628 132.655 1.00 34.41  ? 3   BMA x O5  1 
HETATM 6453 O O6  . BMA D 3 .   ? 145.032 135.567 134.893 1.00 34.41  ? 3   BMA x O6  1 
HETATM 6454 C C1  . MAN D 3 .   ? 139.613 136.424 132.538 1.00 33.54  ? 4   MAN x C1  1 
HETATM 6455 C C2  . MAN D 3 .   ? 138.840 137.269 133.556 1.00 33.54  ? 4   MAN x C2  1 
HETATM 6456 C C3  . MAN D 3 .   ? 138.210 136.375 134.620 1.00 33.54  ? 4   MAN x C3  1 
HETATM 6457 C C4  . MAN D 3 .   ? 137.361 135.287 133.974 1.00 33.54  ? 4   MAN x C4  1 
HETATM 6458 C C5  . MAN D 3 .   ? 138.214 134.518 132.959 1.00 33.54  ? 4   MAN x C5  1 
HETATM 6459 C C6  . MAN D 3 .   ? 137.395 133.509 132.182 1.00 33.54  ? 4   MAN x C6  1 
HETATM 6460 O O2  . MAN D 3 .   ? 137.868 137.985 132.833 1.00 33.54  ? 4   MAN x O2  1 
HETATM 6461 O O3  . MAN D 3 .   ? 137.447 137.200 135.469 1.00 33.54  ? 4   MAN x O3  1 
HETATM 6462 O O4  . MAN D 3 .   ? 136.898 134.449 135.012 1.00 33.54  ? 4   MAN x O4  1 
HETATM 6463 O O5  . MAN D 3 .   ? 138.779 135.418 132.019 1.00 33.54  ? 4   MAN x O5  1 
HETATM 6464 O O6  . MAN D 3 .   ? 138.250 132.503 131.695 1.00 33.54  ? 4   MAN x O6  1 
HETATM 6465 C C1  . MAN D 3 .   ? 146.194 136.224 135.448 1.00 44.76  ? 5   MAN x C1  1 
HETATM 6466 C C2  . MAN D 3 .   ? 147.061 135.147 136.108 1.00 44.76  ? 5   MAN x C2  1 
HETATM 6467 C C3  . MAN D 3 .   ? 146.334 134.562 137.314 1.00 44.76  ? 5   MAN x C3  1 
HETATM 6468 C C4  . MAN D 3 .   ? 145.967 135.668 138.295 1.00 44.76  ? 5   MAN x C4  1 
HETATM 6469 C C5  . MAN D 3 .   ? 145.145 136.738 137.567 1.00 44.76  ? 5   MAN x C5  1 
HETATM 6470 C C6  . MAN D 3 .   ? 144.901 137.951 138.440 1.00 44.76  ? 5   MAN x C6  1 
HETATM 6471 O O2  . MAN D 3 .   ? 148.270 135.765 136.476 1.00 44.76  ? 5   MAN x O2  1 
HETATM 6472 O O3  . MAN D 3 .   ? 147.180 133.599 137.897 1.00 44.76  ? 5   MAN x O3  1 
HETATM 6473 O O4  . MAN D 3 .   ? 145.233 135.068 139.340 1.00 44.76  ? 5   MAN x O4  1 
HETATM 6474 O O5  . MAN D 3 .   ? 145.825 137.190 136.403 1.00 44.76  ? 5   MAN x O5  1 
HETATM 6475 O O6  . MAN D 3 .   ? 144.244 138.937 137.681 1.00 44.76  ? 5   MAN x O6  1 
HETATM 6476 C C1  . NAG E 4 .   ? 143.683 152.483 90.770  1.00 24.86  ? 1   NAG y C1  1 
HETATM 6477 C C2  . NAG E 4 .   ? 144.934 152.246 91.621  1.00 24.86  ? 1   NAG y C2  1 
HETATM 6478 C C3  . NAG E 4 .   ? 144.526 151.563 92.924  1.00 24.86  ? 1   NAG y C3  1 
HETATM 6479 C C4  . NAG E 4 .   ? 143.436 152.362 93.639  1.00 24.86  ? 1   NAG y C4  1 
HETATM 6480 C C5  . NAG E 4 .   ? 142.295 152.677 92.661  1.00 24.86  ? 1   NAG y C5  1 
HETATM 6481 C C6  . NAG E 4 .   ? 141.212 153.557 93.245  1.00 24.86  ? 1   NAG y C6  1 
HETATM 6482 C C7  . NAG E 4 .   ? 147.107 151.924 90.510  1.00 24.86  ? 1   NAG y C7  1 
HETATM 6483 C C8  . NAG E 4 .   ? 147.969 150.924 89.777  1.00 24.86  ? 1   NAG y C8  1 
HETATM 6484 N N2  . NAG E 4 .   ? 145.908 151.461 90.909  1.00 24.86  ? 1   NAG y N2  1 
HETATM 6485 O O3  . NAG E 4 .   ? 145.683 151.413 93.704  1.00 24.86  ? 1   NAG y O3  1 
HETATM 6486 O O4  . NAG E 4 .   ? 142.973 151.583 94.722  1.00 24.86  ? 1   NAG y O4  1 
HETATM 6487 O O5  . NAG E 4 .   ? 142.807 153.305 91.502  1.00 24.86  ? 1   NAG y O5  1 
HETATM 6488 O O6  . NAG E 4 .   ? 140.532 152.862 94.261  1.00 24.86  ? 1   NAG y O6  1 
HETATM 6489 O O7  . NAG E 4 .   ? 147.491 153.066 90.715  1.00 24.86  ? 1   NAG y O7  1 
HETATM 6490 C C1  . NAG E 4 .   ? 143.529 152.078 95.957  1.00 23.26  ? 2   NAG y C1  1 
HETATM 6491 C C2  . NAG E 4 .   ? 142.667 151.580 97.126  1.00 23.26  ? 2   NAG y C2  1 
HETATM 6492 C C3  . NAG E 4 .   ? 143.288 152.010 98.454  1.00 23.26  ? 2   NAG y C3  1 
HETATM 6493 C C4  . NAG E 4 .   ? 144.750 151.582 98.527  1.00 23.26  ? 2   NAG y C4  1 
HETATM 6494 C C5  . NAG E 4 .   ? 145.487 152.110 97.292  1.00 23.26  ? 2   NAG y C5  1 
HETATM 6495 C C6  . NAG E 4 .   ? 146.950 151.726 97.239  1.00 23.26  ? 2   NAG y C6  1 
HETATM 6496 C C7  . NAG E 4 .   ? 140.223 151.277 97.024  1.00 23.26  ? 2   NAG y C7  1 
HETATM 6497 C C8  . NAG E 4 .   ? 138.905 152.006 96.920  1.00 23.26  ? 2   NAG y C8  1 
HETATM 6498 N N2  . NAG E 4 .   ? 141.315 152.064 97.032  1.00 23.26  ? 2   NAG y N2  1 
HETATM 6499 O O3  . NAG E 4 .   ? 142.523 151.451 99.489  1.00 23.26  ? 2   NAG y O3  1 
HETATM 6500 O O4  . NAG E 4 .   ? 145.284 152.111 99.718  1.00 23.26  ? 2   NAG y O4  1 
HETATM 6501 O O5  . NAG E 4 .   ? 144.850 151.618 96.131  1.00 23.26  ? 2   NAG y O5  1 
HETATM 6502 O O6  . NAG E 4 .   ? 147.076 150.326 97.310  1.00 23.26  ? 2   NAG y O6  1 
HETATM 6503 O O7  . NAG E 4 .   ? 140.272 150.058 97.096  1.00 23.26  ? 2   NAG y O7  1 
HETATM 6504 C C1  . BMA E 4 .   ? 145.587 151.025 100.620 1.00 25.93  ? 3   BMA y C1  1 
HETATM 6505 C C2  . BMA E 4 .   ? 146.698 151.496 101.553 1.00 25.93  ? 3   BMA y C2  1 
HETATM 6506 C C3  . BMA E 4 .   ? 147.079 150.361 102.533 1.00 25.93  ? 3   BMA y C3  1 
HETATM 6507 C C4  . BMA E 4 .   ? 145.956 149.336 102.804 1.00 25.93  ? 3   BMA y C4  1 
HETATM 6508 C C5  . BMA E 4 .   ? 144.545 149.862 102.530 1.00 25.93  ? 3   BMA y C5  1 
HETATM 6509 C C6  . BMA E 4 .   ? 143.938 150.606 103.717 1.00 25.93  ? 3   BMA y C6  1 
HETATM 6510 O O2  . BMA E 4 .   ? 146.264 152.658 102.206 1.00 25.93  ? 3   BMA y O2  1 
HETATM 6511 O O3  . BMA E 4 .   ? 147.541 150.988 103.704 1.00 25.93  ? 3   BMA y O3  1 
HETATM 6512 O O4  . BMA E 4 .   ? 146.248 148.213 101.992 1.00 25.93  ? 3   BMA y O4  1 
HETATM 6513 O O5  . BMA E 4 .   ? 144.435 150.665 101.363 1.00 25.93  ? 3   BMA y O5  1 
HETATM 6514 O O6  . BMA E 4 .   ? 143.708 149.663 104.741 1.00 25.93  ? 3   BMA y O6  1 
HETATM 6515 C C1  . NAG F 3 .   ? 121.833 135.199 122.209 1.00 18.23  ? 1   NAG z C1  1 
HETATM 6516 C C2  . NAG F 3 .   ? 123.069 134.401 122.640 1.00 18.23  ? 1   NAG z C2  1 
HETATM 6517 C C3  . NAG F 3 .   ? 122.742 133.584 123.888 1.00 18.23  ? 1   NAG z C3  1 
HETATM 6518 C C4  . NAG F 3 .   ? 122.150 134.472 124.980 1.00 18.23  ? 1   NAG z C4  1 
HETATM 6519 C C5  . NAG F 3 .   ? 120.985 135.288 124.406 1.00 18.23  ? 1   NAG z C5  1 
HETATM 6520 C C6  . NAG F 3 .   ? 120.364 136.251 125.394 1.00 18.23  ? 1   NAG z C6  1 
HETATM 6521 C C7  . NAG F 3 .   ? 124.670 133.728 120.889 1.00 18.23  ? 1   NAG z C7  1 
HETATM 6522 C C8  . NAG F 3 .   ? 124.939 132.704 119.813 1.00 18.23  ? 1   NAG z C8  1 
HETATM 6523 N N2  . NAG F 3 .   ? 123.525 133.549 121.574 1.00 18.23  ? 1   NAG z N2  1 
HETATM 6524 O O3  . NAG F 3 .   ? 123.919 132.946 124.307 1.00 18.23  ? 1   NAG z O3  1 
HETATM 6525 O O4  . NAG F 3 .   ? 121.721 133.624 126.021 1.00 18.23  ? 1   NAG z O4  1 
HETATM 6526 O O5  . NAG F 3 .   ? 121.428 136.020 123.280 1.00 18.23  ? 1   NAG z O5  1 
HETATM 6527 O O6  . NAG F 3 .   ? 121.351 137.123 125.892 1.00 18.23  ? 1   NAG z O6  1 
HETATM 6528 O O7  . NAG F 3 .   ? 125.449 134.644 121.106 1.00 18.23  ? 1   NAG z O7  1 
HETATM 6529 C C1  . NAG F 3 .   ? 122.550 133.830 127.184 1.00 19.91  ? 2   NAG z C1  1 
HETATM 6530 C C2  . NAG F 3 .   ? 121.716 133.517 128.435 1.00 19.91  ? 2   NAG z C2  1 
HETATM 6531 C C3  . NAG F 3 .   ? 122.583 133.610 129.689 1.00 19.91  ? 2   NAG z C3  1 
HETATM 6532 C C4  . NAG F 3 .   ? 123.858 132.786 129.543 1.00 19.91  ? 2   NAG z C4  1 
HETATM 6533 C C5  . NAG F 3 .   ? 124.563 133.184 128.241 1.00 19.91  ? 2   NAG z C5  1 
HETATM 6534 C C6  . NAG F 3 .   ? 125.841 132.423 127.964 1.00 19.91  ? 2   NAG z C6  1 
HETATM 6535 C C7  . NAG F 3 .   ? 119.307 134.040 128.553 1.00 19.91  ? 2   NAG z C7  1 
HETATM 6536 C C8  . NAG F 3 .   ? 118.315 135.170 128.681 1.00 19.91  ? 2   NAG z C8  1 
HETATM 6537 N N2  . NAG F 3 .   ? 120.599 134.417 128.545 1.00 19.91  ? 2   NAG z N2  1 
HETATM 6538 O O3  . NAG F 3 .   ? 121.809 133.187 130.781 1.00 19.91  ? 2   NAG z O3  1 
HETATM 6539 O O4  . NAG F 3 .   ? 124.647 133.065 130.677 1.00 19.91  ? 2   NAG z O4  1 
HETATM 6540 O O5  . NAG F 3 .   ? 123.677 132.984 127.157 1.00 19.91  ? 2   NAG z O5  1 
HETATM 6541 O O6  . NAG F 3 .   ? 125.580 131.039 127.956 1.00 19.91  ? 2   NAG z O6  1 
HETATM 6542 O O7  . NAG F 3 .   ? 118.943 132.877 128.466 1.00 19.91  ? 2   NAG z O7  1 
HETATM 6543 C C1  . BMA F 3 .   ? 124.900 131.846 131.411 1.00 23.21  ? 3   BMA z C1  1 
HETATM 6544 C C2  . BMA F 3 .   ? 126.124 132.092 132.283 1.00 23.21  ? 3   BMA z C2  1 
HETATM 6545 C C3  . BMA F 3 .   ? 126.492 130.792 133.035 1.00 23.21  ? 3   BMA z C3  1 
HETATM 6546 C C4  . BMA F 3 .   ? 125.306 129.844 133.315 1.00 23.21  ? 3   BMA z C4  1 
HETATM 6547 C C5  . BMA F 3 .   ? 123.924 130.499 133.229 1.00 23.21  ? 3   BMA z C5  1 
HETATM 6548 C C6  . BMA F 3 .   ? 123.463 131.052 134.575 1.00 23.21  ? 3   BMA z C6  1 
HETATM 6549 O O2  . BMA F 3 .   ? 125.847 133.163 133.145 1.00 23.21  ? 3   BMA z O2  1 
HETATM 6550 O O3  . BMA F 3 .   ? 127.180 131.188 134.198 1.00 23.21  ? 3   BMA z O3  1 
HETATM 6551 O O4  . BMA F 3 .   ? 125.430 128.793 132.378 1.00 23.21  ? 3   BMA z O4  1 
HETATM 6552 O O5  . BMA F 3 .   ? 123.793 131.496 132.223 1.00 23.21  ? 3   BMA z O5  1 
HETATM 6553 O O6  . BMA F 3 .   ? 122.622 132.163 134.345 1.00 23.21  ? 3   BMA z O6  1 
HETATM 6554 C C1  . MAN F 3 .   ? 128.066 130.120 134.605 1.00 27.60  ? 4   MAN z C1  1 
HETATM 6555 C C2  . MAN F 3 .   ? 128.623 130.478 135.988 1.00 27.60  ? 4   MAN z C2  1 
HETATM 6556 C C3  . MAN F 3 .   ? 129.555 131.682 135.888 1.00 27.60  ? 4   MAN z C3  1 
HETATM 6557 C C4  . MAN F 3 .   ? 130.657 131.416 134.871 1.00 27.60  ? 4   MAN z C4  1 
HETATM 6558 C C5  . MAN F 3 .   ? 130.019 131.051 133.527 1.00 27.60  ? 4   MAN z C5  1 
HETATM 6559 C C6  . MAN F 3 .   ? 131.054 130.632 132.505 1.00 27.60  ? 4   MAN z C6  1 
HETATM 6560 O O2  . MAN F 3 .   ? 129.295 129.337 136.463 1.00 27.60  ? 4   MAN z O2  1 
HETATM 6561 O O3  . MAN F 3 .   ? 130.074 131.927 137.174 1.00 27.60  ? 4   MAN z O3  1 
HETATM 6562 O O4  . MAN F 3 .   ? 131.433 132.592 134.781 1.00 27.60  ? 4   MAN z O4  1 
HETATM 6563 O O5  . MAN F 3 .   ? 129.120 129.962 133.686 1.00 27.60  ? 4   MAN z O5  1 
HETATM 6564 O O6  . MAN F 3 .   ? 130.418 130.421 131.268 1.00 27.60  ? 4   MAN z O6  1 
HETATM 6565 C C1  . MAN F 3 .   ? 121.349 131.948 134.999 1.00 26.23  ? 5   MAN z C1  1 
HETATM 6566 C C2  . MAN F 3 .   ? 120.456 133.151 134.674 1.00 26.23  ? 5   MAN z C2  1 
HETATM 6567 C C3  . MAN F 3 .   ? 121.005 134.406 135.344 1.00 26.23  ? 5   MAN z C3  1 
HETATM 6568 C C4  . MAN F 3 .   ? 121.121 134.189 136.847 1.00 26.23  ? 5   MAN z C4  1 
HETATM 6569 C C5  . MAN F 3 .   ? 121.992 132.956 137.111 1.00 26.23  ? 5   MAN z C5  1 
HETATM 6570 C C6  . MAN F 3 .   ? 122.008 132.580 138.577 1.00 26.23  ? 5   MAN z C6  1 
HETATM 6571 O O2  . MAN F 3 .   ? 119.164 132.836 135.133 1.00 26.23  ? 5   MAN z O2  1 
HETATM 6572 O O3  . MAN F 3 .   ? 120.139 135.471 135.030 1.00 26.23  ? 5   MAN z O3  1 
HETATM 6573 O O4  . MAN F 3 .   ? 121.694 135.359 137.391 1.00 26.23  ? 5   MAN z O4  1 
HETATM 6574 O O5  . MAN F 3 .   ? 121.504 131.829 136.395 1.00 26.23  ? 5   MAN z O5  1 
HETATM 6575 O O6  . MAN F 3 .   ? 122.803 131.431 138.746 1.00 26.23  ? 5   MAN z O6  1 
HETATM 6576 C C1  . NAG G 5 .   ? 157.816 140.636 112.653 1.00 37.44  ? 501 NAG F C1  1 
HETATM 6577 C C2  . NAG G 5 .   ? 159.128 140.950 111.921 1.00 37.44  ? 501 NAG F C2  1 
HETATM 6578 C C3  . NAG G 5 .   ? 158.837 141.316 110.468 1.00 37.44  ? 501 NAG F C3  1 
HETATM 6579 C C4  . NAG G 5 .   ? 157.993 140.232 109.808 1.00 37.44  ? 501 NAG F C4  1 
HETATM 6580 C C5  . NAG G 5 .   ? 156.743 139.971 110.657 1.00 37.44  ? 501 NAG F C5  1 
HETATM 6581 C C6  . NAG G 5 .   ? 155.846 138.886 110.105 1.00 37.44  ? 501 NAG F C6  1 
HETATM 6582 C C7  . NAG G 5 .   ? 161.005 141.862 113.256 1.00 37.44  ? 501 NAG F C7  1 
HETATM 6583 C C8  . NAG G 5 .   ? 161.565 140.461 113.297 1.00 37.44  ? 501 NAG F C8  1 
HETATM 6584 N N2  . NAG G 5 .   ? 159.846 142.008 112.584 1.00 37.44  ? 501 NAG F N2  1 
HETATM 6585 O O3  . NAG G 5 .   ? 160.064 141.498 109.813 1.00 37.44  ? 501 NAG F O3  1 
HETATM 6586 O O4  . NAG G 5 .   ? 157.661 140.687 108.517 1.00 37.44  ? 501 NAG F O4  1 
HETATM 6587 O O5  . NAG G 5 .   ? 157.137 139.611 111.966 1.00 37.44  ? 501 NAG F O5  1 
HETATM 6588 O O6  . NAG G 5 .   ? 156.585 137.699 109.936 1.00 37.44  ? 501 NAG F O6  1 
HETATM 6589 O O7  . NAG G 5 .   ? 161.581 142.790 113.805 1.00 37.44  ? 501 NAG F O7  1 
HETATM 6590 C C1  . NAG H 5 .   ? 126.538 130.007 98.631  1.00 13.46  ? 301 NAG A C1  1 
HETATM 6591 C C2  . NAG H 5 .   ? 126.832 128.525 98.902  1.00 13.46  ? 301 NAG A C2  1 
HETATM 6592 C C3  . NAG H 5 .   ? 128.180 128.147 98.292  1.00 13.46  ? 301 NAG A C3  1 
HETATM 6593 C C4  . NAG H 5 .   ? 128.219 128.522 96.816  1.00 13.46  ? 301 NAG A C4  1 
HETATM 6594 C C5  . NAG H 5 .   ? 127.868 130.005 96.662  1.00 13.46  ? 301 NAG A C5  1 
HETATM 6595 C C6  . NAG H 5 .   ? 127.829 130.471 95.223  1.00 13.46  ? 301 NAG A C6  1 
HETATM 6596 C C7  . NAG H 5 .   ? 126.021 127.329 100.894 1.00 13.46  ? 301 NAG A C7  1 
HETATM 6597 C C8  . NAG H 5 .   ? 126.190 127.191 102.387 1.00 13.46  ? 301 NAG A C8  1 
HETATM 6598 N N2  . NAG H 5 .   ? 126.825 128.236 100.311 1.00 13.46  ? 301 NAG A N2  1 
HETATM 6599 O O3  . NAG H 5 .   ? 128.373 126.771 98.489  1.00 13.46  ? 301 NAG A O3  1 
HETATM 6600 O O4  . NAG H 5 .   ? 129.518 128.243 96.346  1.00 13.46  ? 301 NAG A O4  1 
HETATM 6601 O O5  . NAG H 5 .   ? 126.602 130.245 97.243  1.00 13.46  ? 301 NAG A O5  1 
HETATM 6602 O O6  . NAG H 5 .   ? 126.905 129.697 94.496  1.00 13.46  ? 301 NAG A O6  1 
HETATM 6603 O O7  . NAG H 5 .   ? 125.208 126.655 100.280 1.00 13.46  ? 301 NAG A O7  1 
HETATM 6604 C C1  . NAG I 5 .   ? 145.611 130.513 91.317  1.00 35.59  ? 302 NAG A C1  1 
HETATM 6605 C C2  . NAG I 5 .   ? 145.401 129.546 92.490  1.00 35.59  ? 302 NAG A C2  1 
HETATM 6606 C C3  . NAG I 5 .   ? 146.718 128.855 92.838  1.00 35.59  ? 302 NAG A C3  1 
HETATM 6607 C C4  . NAG I 5 .   ? 147.344 128.230 91.596  1.00 35.59  ? 302 NAG A C4  1 
HETATM 6608 C C5  . NAG I 5 .   ? 147.464 129.295 90.501  1.00 35.59  ? 302 NAG A C5  1 
HETATM 6609 C C6  . NAG I 5 .   ? 148.061 128.784 89.209  1.00 35.59  ? 302 NAG A C6  1 
HETATM 6610 C C7  . NAG I 5 .   ? 143.650 130.047 94.154  1.00 35.59  ? 302 NAG A C7  1 
HETATM 6611 C C8  . NAG I 5 .   ? 143.328 130.888 95.365  1.00 35.59  ? 302 NAG A C8  1 
HETATM 6612 N N2  . NAG I 5 .   ? 144.879 130.236 93.640  1.00 35.59  ? 302 NAG A N2  1 
HETATM 6613 O O3  . NAG I 5 .   ? 146.457 127.898 93.831  1.00 35.59  ? 302 NAG A O3  1 
HETATM 6614 O O4  . NAG I 5 .   ? 148.604 127.724 91.970  1.00 35.59  ? 302 NAG A O4  1 
HETATM 6615 O O5  . NAG I 5 .   ? 146.179 129.817 90.232  1.00 35.59  ? 302 NAG A O5  1 
HETATM 6616 O O6  . NAG I 5 .   ? 148.016 129.797 88.231  1.00 35.59  ? 302 NAG A O6  1 
HETATM 6617 O O7  . NAG I 5 .   ? 142.840 129.257 93.692  1.00 35.59  ? 302 NAG A O7  1 
HETATM 6618 C C1  . NAG J 5 .   ? 127.105 152.751 103.613 1.00 34.68  ? 303 NAG A C1  1 
HETATM 6619 C C2  . NAG J 5 .   ? 126.037 153.630 104.290 1.00 34.68  ? 303 NAG A C2  1 
HETATM 6620 C C3  . NAG J 5 .   ? 126.676 154.557 105.330 1.00 34.68  ? 303 NAG A C3  1 
HETATM 6621 C C4  . NAG J 5 .   ? 127.574 153.762 106.274 1.00 34.68  ? 303 NAG A C4  1 
HETATM 6622 C C5  . NAG J 5 .   ? 128.556 152.912 105.459 1.00 34.68  ? 303 NAG A C5  1 
HETATM 6623 C C6  . NAG J 5 .   ? 129.491 152.074 106.303 1.00 34.68  ? 303 NAG A C6  1 
HETATM 6624 C C7  . NAG J 5 .   ? 125.350 155.259 102.393 1.00 34.68  ? 303 NAG A C7  1 
HETATM 6625 C C8  . NAG J 5 .   ? 126.734 155.812 102.126 1.00 34.68  ? 303 NAG A C8  1 
HETATM 6626 N N2  . NAG J 5 .   ? 125.159 154.317 103.355 1.00 34.68  ? 303 NAG A N2  1 
HETATM 6627 O O3  . NAG J 5 .   ? 125.646 155.218 106.016 1.00 34.68  ? 303 NAG A O3  1 
HETATM 6628 O O4  . NAG J 5 .   ? 128.245 154.691 107.093 1.00 34.68  ? 303 NAG A O4  1 
HETATM 6629 O O5  . NAG J 5 .   ? 127.826 152.055 104.603 1.00 34.68  ? 303 NAG A O5  1 
HETATM 6630 O O6  . NAG J 5 .   ? 130.302 151.281 105.469 1.00 34.68  ? 303 NAG A O6  1 
HETATM 6631 O O7  . NAG J 5 .   ? 124.412 155.675 101.730 1.00 34.68  ? 303 NAG A O7  1 
HETATM 6632 C C1  . NAG K 5 .   ? 110.195 114.339 120.272 1.00 33.31  ? 501 NAG E C1  1 
HETATM 6633 C C2  . NAG K 5 .   ? 108.969 113.817 119.512 1.00 33.31  ? 501 NAG E C2  1 
HETATM 6634 C C3  . NAG K 5 .   ? 109.400 112.729 118.532 1.00 33.31  ? 501 NAG E C3  1 
HETATM 6635 C C4  . NAG K 5 .   ? 110.520 113.242 117.633 1.00 33.31  ? 501 NAG E C4  1 
HETATM 6636 C C5  . NAG K 5 .   ? 111.652 113.812 118.497 1.00 33.31  ? 501 NAG E C5  1 
HETATM 6637 C C6  . NAG K 5 .   ? 112.802 114.385 117.698 1.00 33.31  ? 501 NAG E C6  1 
HETATM 6638 C C7  . NAG K 5 .   ? 106.774 113.917 120.625 1.00 33.31  ? 501 NAG E C7  1 
HETATM 6639 C C8  . NAG K 5 .   ? 105.881 113.226 121.626 1.00 33.31  ? 501 NAG E C8  1 
HETATM 6640 N N2  . NAG K 5 .   ? 107.967 113.327 120.421 1.00 33.31  ? 501 NAG E N2  1 
HETATM 6641 O O3  . NAG K 5 .   ? 108.273 112.336 117.795 1.00 33.31  ? 501 NAG E O3  1 
HETATM 6642 O O4  . NAG K 5 .   ? 110.959 112.156 116.850 1.00 33.31  ? 501 NAG E O4  1 
HETATM 6643 O O5  . NAG K 5 .   ? 111.132 114.823 119.339 1.00 33.31  ? 501 NAG E O5  1 
HETATM 6644 O O6  . NAG K 5 .   ? 113.445 113.354 116.986 1.00 33.31  ? 501 NAG E O6  1 
HETATM 6645 O O7  . NAG K 5 .   ? 106.421 114.938 120.053 1.00 33.31  ? 501 NAG E O7  1 
# 
